DOI: 10.5281/zenodo.13143981
title: Dataset for Diamond-coated quartz crystal microbalance sensors: Challenges in high yield production and enhanced detection of ethanol and sars-cov-2 proteins

description: The data set to paper: 

Name:             Diamond-coated quartz crystal microbalance challenges in mass production and enhanced detection of ethanol and sars-cov-2 proteins

Authors:        Tibor Izsák1*, Marian Varga1, Michal Kočí2,3, Ondrej Szabó2, Katarína Aubrechtová Dragounová2, Gabriel Vanko2, Miroslav Gál4, Jana Korčeková5, Michaela Hornychová 4, Alexandra Poturnayová5, Alexander Kromka2*

Affiliations:        1 Department of Microelectronics and Sensors, Institute of Electrical Engineering, Slovak Academy of Sciences, Dúbravská Cesta 9, Bratislava, 841 04, Slovak Republic            2 Department of Semiconductors, Institute of Physics of the Czech Academy of Sciences, Cukrovarnicka 10/112, Prague 6 162 00, Czech Republic            3 Department of Microelectronics, Faculty of Electrical Engineering, Czech Technical University in Prague, Technická 2, Prague 6, 166 27, Czech Republic            4 Faculty of Chemical and Food Technology, Slovak University of Technology, Bratislava, Slovak Republic            5 Center of Biosciences, Institute of Molecular Physiology and Genetics, Slovak Academy of Sciences, Bratislava, Slovak Republic            *corresponding author: tibor.izsak@savba.sk

Data manager:         Kristýna Dostálová: dostalovak@fzu.cz

Date of collection:    1. 5. 2023 - 31. 7. 2024

Description:        Figure 1: Photos of QCM substrates oriented horizontally or vertically on the substrate holder in the deposition chamber (left) and during the diamond CVD process with ignited plasma (right).            Figure 2: a) 3D model of the measurement setup and b) photograph of the open gas chamber with embedded QCM sample.            Figure 3: Photo of the a) measurement setup and b) disassembled flow cell with V-Dia-QCM. c) Side view photo of the assembled flow cell in the measurement setup.            Figure 4: a) SEM images revealing surface morphology and b) corresponding Raman spectra of Dia-QCM and Dia-Si substrates horizontally or vertically oriented on the substrate holder and corresponding optical photos. There is also the Raman spectrum of the bare QCM (Au-QCM) sample before the diamond deposition.            Figure 5: a) Raman spectra and b) SEM images depicting surface morphology of porous diamond film grown on Si (H-PorDia-Si) and QCM (H-PorDia-QCM) substrate. The inset in Fig. 5a represents the optical photo of diamond-coated QCM. Note: ‘H-’ in sample names means horizontally loaded samples.            Figure 6: The response delta fR of diamond-coated QCM sensors horizontally and vertically oriented, i.e., single-sided and double-sided diamond-coated QCMs, when applying periodic switching (at 3-minute intervals) of ethanol vapour (E) with various concentrations (from 10 ppm to 100 ppm) and synthetic air (Air).            Figure 7: a) First resonant frequency shift (delta fR) of individual QCM sensors and b) mean values of delta fR with corresponding error bars for each QCM sensor group dependent on ethanol concentration.            Figure 8: a) The changes of the resonant frequency, delta fR, after the addition of neutravidin (NA) dissolved in water, biotinylated 1C aptamers (1C APT) dissolved in PBS with MgCl2, and 50 pg/mL S-RBD protein in PBS. The addition of neutravidin, aptamers, proteins, and surface washings by water (H2O) or buffer (PBS) are highlighted by arrows. b) Zoom in on the highlighted area in Fig. 8a.            Figure 9: Decrease of the resonant frequency, fR, at various S-RBD protein concentrations. The comparison of the sensitivity of diamond and gold QCM surfaces on which S-RBD was determined is indicated in the graph legend.