cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.5281/zenodo.3709258
title: Dataset related to the article "MiRNA profiling revealed enhanced susceptibility to oxidative stress of endothelial cells from bicuspid aortic valve"

description: This record contains raw data related to the article "MiRNA profiling revealed enhanced susceptibility to oxidative stress of endothelial cells from bicuspid aortic valve" <strong>Abstract</strong> Aims Calcific aortic valve stenosis (CAVS) is the most frequent manifestation of aortic valve disease and the third leading cause of cardiovascular disease in the Western countries associated with significant morbidity and mortality. An active biological progression involving inflammation and oxidation leading to valve endothelial damage is considered a hallmark of the early stages of valve degeneration. However, tricuspid (TAV) and bicuspid (BAV) aortic valve deterioration are considered to differ only by shear stress. We hypothesized that endothelial cells (EC) derived from BAV and TAV patients have different miRNA expression patterns and thus distinct pathways could lead to endothelial damage in BAV than TAV patients. Methods and results We isolated ECs from patients with bicuspid or tricuspid aortic valve, which underwent surgery due to CAVS. MiRNA expression profile by PCR revealed eight upregulated miRNAs between BAV and TAV ECs. Functional analysis identified that BAV ECs presented altered cellular response to oxidative stress and DNA damage stimulus <em>via</em> p53 and alteration in the intrinsic apoptotic signaling pathway. GPX3 and SRXN1 mRNA were express at lower levels in BAV compared to TAV ECs, leading to an increment of DNA double-strand breaks. BAV ECs had a sustained apoptosis activation when compared to TAV ECs. This difference was exacerbated by oxidative stress stimulus leading to a reduced survival rate but completely reverted by miR-328-3p inhibition. Conclusion The present data showed molecular differences in oxidative stress susceptibility, DNA damage magnitude, and apoptosis induction between ECs derived from BAV and TAV patients.
description: This work was supported by the Fondazione Gigi e Pupa Ferrari ONLUS [FPF-14 to P·P]; and the Italian Ministry of Health [RC2016-BIO34-2627243 to P.P. at Centro Cardiologico Monzino].
DOI: 10.17632/wrk3krr9hv.2
title: Control of food approach and eating by a GABAergic projection from lateral hypothalamus to dorsal pons

description: Data deposit for the manuscript: "Control of food approach and eating by a GABAergic projection from lateral hypothalamus to dorsal pons"
DOI: 10.17632/wrk3krr9hv.3
title: Control of food approach and eating by a GABAergic projection from lateral hypothalamus to dorsal pons

description: Data deposit for the manuscript: "Control of food approach and eating by a GABAergic projection from lateral hypothalamus to dorsal pons"
DOI: 10.5281/zenodo.3671214
title: MAP-search-data

description: Pickle dictionary and LSH forest of ChEMBL, the Human Metabolome, and SwissProt necessary to run the MAP Similarity Search locally.
DOI: 10.5281/zenodo.3671213
title: MAP-search-data

description: Pickle dictionary and LSH forest of ChEMBL, the Human Metabolome, and SwissProt necessary to run the MAP Similarity Search locally.
DOI: 10.5281/zenodo.3709255
title: Geographical location of the four Sinitic groups

description: Geographical location of the four Sinitic groups
DOI: 10.5281/zenodo.3709254
title: Geographical location of the four Sinitic groups

description: Geographical location of the four Sinitic groups
DOI: 10.5281/zenodo.3708500
title: ecPoint_GitHub_TestData

description: One day of test data, with input and output files to run ecPoint (https://github.com/ecmwf/ecPoint).
DOI: 10.5281/zenodo.3708501
title: ecPoint_GitHub_TestData

description: One day of test data, with input and output files to run ecPoint (https://github.com/ecmwf/ecPoint).
DOI: 10.5519/qd.f0ckftni
title: Query on the Natural History Museum Data Portal (data.nhm.ac.uk) (701 records)
DOI: 10.5281/zenodo.3709257
title: DATA for "Towards ultrasound enhanced mid-IR spectroscopy for sensing bacteria in aqueous solutions"

description: Dataset for DOI: 10.1117/12.2290390.
DOI: 10.5281/zenodo.3709256
title: DATA for "Towards ultrasound enhanced mid-IR spectroscopy for sensing bacteria in aqueous solutions"

description: Dataset for DOI: 10.1117/12.2290390.
DOI: 10.34740/kaggle/dsv/1387527
title: GlassDoor(Data Scientist)
DOI: 10.5281/zenodo.3709277
title: Dataset related to the article: "Generation of three iPSC lines (IAIi002, IAIi004, IAIi003) from Rubinstein-Taybi syndrome 1 patients carrying CREBBP non sense c.4435G&gt;T, p.(Gly1479*) and c.3474G&gt;A, p.(Trp1158*) and missense c.4627G&gt;T, p.(Asp1543Tyr) mutations"

description: This record contains raw data related to the article: "Generation of three iPSC lines (IAIi002, IAIi004, IAIi003) from Rubinstein-Taybi syndrome 1 patients carrying CREBBP non sense c.4435G&gt;T, p.(Gly1479*) and c.3474G&gt;A, p.(Trp1158*) and missense c.4627G&gt;T, p.(Asp1543Tyr) mutations." Abstract: Rubinstein-Taybi syndrome (RSTS) is a neurodevelopmental disorder characterized by growth retardation, skeletal anomalies and intellectual disability, caused by heterozygous mutations in either CREBBP (RSTS1) or EP300 (RSTS2) genes. We characterized 3 iPSC lines generated by Sendai from blood of RSTS1 patients with unique non sense c.4435G &gt; T, p.(Gly1479*), c.3474G &gt; A, p.(Trp1158*) and missense c.4627G &gt; T, p.(Asp1543Tyr) CREBBP mutations. All lines displayed iPSC morphology, pluripotency markers, trilineage differentiation potential, stable karyotype and specific mutations. Western-blot using a CREB- Binding Protein N-terminus antibody demonstrated the same amount of full length protein as control in the missense mutation line and reduced amount in lines with stop mutations.
DOI: 10.5281/zenodo.3709276
title: Dataset related to the article: "Generation of three iPSC lines (IAIi002, IAIi004, IAIi003) from Rubinstein-Taybi syndrome 1 patients carrying CREBBP non sense c.4435G&gt;T, p.(Gly1479*) and c.3474G&gt;A, p.(Trp1158*) and missense c.4627G&gt;T, p.(Asp1543Tyr) mutations"

description: This record contains raw data related to the article: "Generation of three iPSC lines (IAIi002, IAIi004, IAIi003) from Rubinstein-Taybi syndrome 1 patients carrying CREBBP non sense c.4435G&gt;T, p.(Gly1479*) and c.3474G&gt;A, p.(Trp1158*) and missense c.4627G&gt;T, p.(Asp1543Tyr) mutations." Abstract: Rubinstein-Taybi syndrome (RSTS) is a neurodevelopmental disorder characterized by growth retardation, skeletal anomalies and intellectual disability, caused by heterozygous mutations in either CREBBP (RSTS1) or EP300 (RSTS2) genes. We characterized 3 iPSC lines generated by Sendai from blood of RSTS1 patients with unique non sense c.4435G &gt; T, p.(Gly1479*), c.3474G &gt; A, p.(Trp1158*) and missense c.4627G &gt; T, p.(Asp1543Tyr) CREBBP mutations. All lines displayed iPSC morphology, pluripotency markers, trilineage differentiation potential, stable karyotype and specific mutations. Western-blot using a CREB- Binding Protein N-terminus antibody demonstrated the same amount of full length protein as control in the missense mutation line and reduced amount in lines with stop mutations.
DOI: 10.5281/zenodo.3709268
title: Dataset related to the article "Establishment of a Duchenne muscular dystrophy patient-derived induced pluripotent stem cell line carrying a deletion of exons 51–53 of the dystrophin gene (CCMi003-A) "

description: This record contains raw data related to the article: "Establishment of a Duchenne muscular dystrophy patient-derived induced pluripotent stem cell line carrying a deletion of exons 51–53 of the dystrophin gene (CCMi003-A) " Abstract: Duchenne's muscular dystrophy (DMD) is a neuromuscular disorder affecting skeletal and cardiac muscle function, caused by mutations in the dystrophin (DMD) gene. Dermal fibroblasts, isolated from a DMD patient with a reported deletion of exons 51 to 53 in the DMD gene, were reprogramed into induced pluripotent stem cells (iPSCs) by electroporation with episomal vectors containing the reprograming factors: OCT4, SOX2, LIN28, KLF4, and L-MYC. The obtained iPSC line showed iPSC morphology, expression of pluripotency markers, possessed trilineage differentiation potential and was karyotypically normal.
description: Founded by: Fondazione IEO-CCM, Italian Ministry of Health, Fondazione Umberto Veronesi, Fondazione Telethon.
DOI: 10.5281/zenodo.3709269
title: Dataset related to the article "Establishment of a Duchenne muscular dystrophy patient-derived induced pluripotent stem cell line carrying a deletion of exons 51–53 of the dystrophin gene (CCMi003-A) "

description: This record contains raw data related to the article: "Establishment of a Duchenne muscular dystrophy patient-derived induced pluripotent stem cell line carrying a deletion of exons 51–53 of the dystrophin gene (CCMi003-A) " Abstract: Duchenne's muscular dystrophy (DMD) is a neuromuscular disorder affecting skeletal and cardiac muscle function, caused by mutations in the dystrophin (DMD) gene. Dermal fibroblasts, isolated from a DMD patient with a reported deletion of exons 51 to 53 in the DMD gene, were reprogramed into induced pluripotent stem cells (iPSCs) by electroporation with episomal vectors containing the reprograming factors: OCT4, SOX2, LIN28, KLF4, and L-MYC. The obtained iPSC line showed iPSC morphology, expression of pluripotency markers, possessed trilineage differentiation potential and was karyotypically normal.
description: Founded by: Fondazione IEO-CCM, Italian Ministry of Health, Fondazione Umberto Veronesi, Fondazione Telethon.
DOI: 10.21227/xfk7-m302
title: Home Electrical Appliances Recordings for NILM

description: We introduce a novel dataset containing a total of 61 distinct HEAs. The proposed appliances (e.g. fans, fridges, washers, etc.) are of different kinds, ages, brands and powerlevels. They have been recorded in steady-state conditions in a French 50 Hz electrical grid. The measurement setup consists of an AC current probe (E3N Chauvin Arnoux) with a 10 mV/A sensitivity and a differential voltage probe witha 1/100 attenuation. Voltage and current waveforms were captured by an 8-bit resolution digital oscilloscope (RIGOL DS1104Z) each corresponding to an acquisition of 8 periods of the utility frequency. The sampling rate was set at Fe=250 kHz for some of the recordings and Fe = 50 kHz for the other part. Each HEA is described by 8 periods of the current and voltage steady-state waveforms, resulting consequently in a set of n = 8 61 = 488 distinct individuals.
DOI: 10.5285/26323d5b-c4a4-48ac-a8f7-9a83f52ddaa4
title: Core Flood Experiments on carbonate rocks

description: Medical CT scans for drainage multiphase flow through carbonate rock cores. The steady state drainage multiphase flow at elevated pressure using nitrogen and DI water, are carried out for three heterogeneous carbonate rocks to characterize the impact of heterogeneity on flow. Core Floods are performed on three carbonate rocks namely, Indiana limestone, Estaillades limestone and Edwards dolomites. Experiments are carried out using medical CT scanner and N2-water fluid system at high pressure. Drainage core floods are carried out by varying nitrogen fractional flow rates from 0 to 1. Residual trapping is obtained at the end of drainage cycle by water flooding of the core. These rocks are from three difference quarries. Indiana carbonate is from Salem Formation located in Indian, USA. Estaillades limestone is from Oppède quarry, France. Edwards dolomite is from Texas, USA.
DOI: 10.26300/ybhb-mz16
title: Screening for Hepatitis C Virus Infection in Adolescents and Adults: A Systematic Review Update for the U.S. Preventive Services Task Force
DOI: 10.21227/e58q-4876
title: Home Electrical Appliances Recordings for NILM

description: We introduce a novel dataset containing a total of 61 distinct HEAs. The proposed appliances (e.g. fans, fridges, washers, etc.) are of different kinds, ages, brands and powerlevels. They have been recorded in steady-state conditions in a French 50 Hz electrical grid. The measurement setup consists of an AC current probe (E3N Chauvin Arnoux) with a 10 mV/A sensitivity and a differential voltage probe witha 1/100 attenuation. Voltage and current waveforms were captured by an 8-bit resolution digital oscilloscope (RIGOL DS1104Z) each corresponding to an acquisition of 8 periods of the utility frequency. The sampling rate was set at Fe=250 kHz for some of the recordings and Fe = 50 kHz for the other part. Each HEA is described by 8 periods of the current and voltage steady-state waveforms, resulting consequently in a set of n = 8 * 61 = 488 distinct individuals.
DOI: 10.15482/usda.adc/1518435
title: Manuresheds: Redesigning crop-livestock agriculture for sustainable intensification

description: Nutrient recycling is fundamental to sustainable agricultural systems, but few mechanisms exist to ensure that surplus manure nutrients from animal feeding operations are transported for use on nutrient-deficient croplands. As a result, manure nutrients concentrate in locations where they can threaten environmental health and devalue manure as a fertilizer resource. This study advances the concept of the “manureshed” – the lands surrounding animal feeding operations onto which manure nutrients can be redistributed to meet environmental, production, and economic goals. Manuresheds can be managed at multiple scales, for example, on farms with both animals and crops, among animal farms and crop farms within a county, or even among animal farms and crop farms in distant counties. With a focus on redistribution among counties, we classified the 3109 counties of the contiguous United States by their capacity to either supply manure phosphorus (P) and nitrogen (N) from confined livestock production (“sources”) or to assimilate and remove excess P and N via crops (“sinks”). Manure nutrient source counties were identified in 40 of the 48 states, with a substantial concentration in the southern US. Source counties for manure P greatly outnumbered source counties for manure N (390 vs. 100), and 99 of the 100 manure N source counties were also source counties for manure P. Conversely, sink counties for manure N outnumbered sink counties for manure P (2766 vs. 2317). We used the P balances of the source and sink counties to delineate four manuresheds dominated by various combinations of confined hog, poultry, dairy, and beef industries. The four manuresheds differed in the transport distances needed to assimilate excess manure P from their respective source areas (from 147 ± 51 km for a beef dominated manureshed to 368 ± 140 km for a poultry dominated manureshed), highlighting the need for systems-level strategies to promote manure nutrient recycling that operate across local, county, regional, and national scales.
DOI: 10.5281/zenodo.3709275
title: NARPS Results

description: Results saved from analysis of Neuroimaging Analysis Replication and Prediction Study. Obtained from CircleCI Build #334 at https://334-85984198-gh.circle-artifacts.com/0/tmp/data/results.tgz
DOI: 10.5281/zenodo.3709302
title: Evaluation data for 'Investigation on the behaviour of kappa carrageenan hydrogels for compressive intra-vessel disintegration'

description: Dataset and evaluation routines for the manuscript '<em>Investigation on the behaviour of kappa carrageenan hydrogels for compressive intra-vessel disintegration'.</em>
DOI: 10.5281/zenodo.3709301
title: Evaluation data for 'Investigation on the behaviour of kappa carrageenan hydrogels for compressive intra-vessel disintegration'

description: Dataset and evaluation routines for the manuscript '<em>Investigation on the behaviour of kappa carrageenan hydrogels for compressive intra-vessel disintegration'.</em>
DOI: 10.15129/c58a7928-a9fe-462d-b3f9-8b5e4df164f4
title: School Resources For: How Safe is Your Playground? Analysing Soil in Scottish Schools Through a University Outreach Project

description: This is the collection of resources and reports from our Royal Society of Chemistry-funded schools outreach project.
DOI: 10.5678/lcrs/dat.362
title: Fog frequencies in Europe (averaged over GWSs)
title: Fog Freq. (GWSs)

description: This dataset contains fog frequencies for Europe averaged over all 30 GWSs (general weather situations) after Hess & Brezowsky. Time period covered: 2006-01-01 to 2015-12-31<br> <br> A description of the data can be found in this paper:<br> Egli, S., Thies, B., & Bendix, J. (2019). A spatially explicit and temporally highly resolved analysis of variations in fog occurrence over Europe. Quarterly Journal of the Royal Meteorological Society, 1–20. https://doi.org/10.1002/qj.3522<br> <br> The original fog masks are based on Meteosat Second Generation data that were processed based on the algorithm described in Egli, S., Thies, B. & Bendix, J. (2018). A Hybrid Approach for Fog Retrieval Based on a Combination of Satellite and Ground Truth Data. Remote Sensing. 2018.
DOI: 10.5281/zenodo.3709343
title: SELENE_COU

description: Glissements sémantiques de COU dans les langues sénégambiennes
DOI: 10.5281/zenodo.3709341
title: Data for: A Pocket-Sized 3D-printed Attenuated Total Reflection-Infrared Filtometer combined with Functionalized Silica Films for Nitrate Sensing in Water

description: Data set for 10.1016/j.snb.2020.127847
DOI: 10.5281/zenodo.3709342
title: Data for: A Pocket-Sized 3D-printed Attenuated Total Reflection-Infrared Filtometer combined with Functionalized Silica Films for Nitrate Sensing in Water

description: Data set for 10.1016/j.snb.2020.127847
DOI: 10.5281/zenodo.3709092
title: A Real-time System for Vision-based Road Cracks Detection via Shallow and Deep Learnings

description: Code and data of "A Real-time System for Vision-based Road Cracks Detection via Shallow and Deep Learnings"
DOI: 10.5281/zenodo.3709093
title: A Real-time System for Vision-based Road Cracks Detection via Shallow and Deep Learnings

description: Code and data of "A Real-time System for Vision-based Road Cracks Detection via Shallow and Deep Learnings"
DOI: 10.5281/zenodo.3709350
title: Dataset related to the article "Endothelial Dysfunction in Patients with Severe Mitral Regurgitation

description: This record contains raw data related to the article "Endothelial Dysfunction in Patients with Severe Mitral Regurgitation" Abstract: Mitral valve prolapse (MVP) is the most common cause of severe mitral regurgitation. It has been reported that MVP patients-candidates for mitral valve repair (MVRep)-showed an alteration in the antioxidant defense systems as well as in the L-arginine metabolic pathway. In this study, we investigate if oxidative stress and endothelial dysfunction are an MVP consequence or driving factors. Forty-five patients undergoing MVRep were evaluated before and 6 months post surgery and compared to 29 controls. Oxidized (GSSG) and reduced (GSH) forms of glutathione, and L-arginine metabolic pathway were analyzed using liquid chromatography-tandem mass spectrometry methods while osteoprotegerin (OPG) through the ELISA kit and circulating endothelial microparticles (EMP) by flow cytometry. Six-month post surgery, in MVP patients, the GSSG/GSH ratio decreased while symmetric and asymmetric dimethylarginines levels remained comparable to the baseline. Conversely, OPG levels significantly increased when compared to their baseline. Finally, pre-MVRep EMP levels were significantly higher in patients than in controls and did not change post surgery. Overall, these results highlight that MVRep completely restores the increased oxidative stress levels, as evidenced in MVP patients. Conversely, no amelioration of endothelial dysfunction was evidenced after surgery. Thus, therapies aimed to restore a proper endothelial function before and after surgical repair could benefit MVP patients
DOI: 10.5281/zenodo.3709351
title: Dataset related to the article "Endothelial Dysfunction in Patients with Severe Mitral Regurgitation

description: This record contains raw data related to the article "Endothelial Dysfunction in Patients with Severe Mitral Regurgitation" Abstract: Mitral valve prolapse (MVP) is the most common cause of severe mitral regurgitation. It has been reported that MVP patients-candidates for mitral valve repair (MVRep)-showed an alteration in the antioxidant defense systems as well as in the L-arginine metabolic pathway. In this study, we investigate if oxidative stress and endothelial dysfunction are an MVP consequence or driving factors. Forty-five patients undergoing MVRep were evaluated before and 6 months post surgery and compared to 29 controls. Oxidized (GSSG) and reduced (GSH) forms of glutathione, and L-arginine metabolic pathway were analyzed using liquid chromatography-tandem mass spectrometry methods while osteoprotegerin (OPG) through the ELISA kit and circulating endothelial microparticles (EMP) by flow cytometry. Six-month post surgery, in MVP patients, the GSSG/GSH ratio decreased while symmetric and asymmetric dimethylarginines levels remained comparable to the baseline. Conversely, OPG levels significantly increased when compared to their baseline. Finally, pre-MVRep EMP levels were significantly higher in patients than in controls and did not change post surgery. Overall, these results highlight that MVRep completely restores the increased oxidative stress levels, as evidenced in MVP patients. Conversely, no amelioration of endothelial dysfunction was evidenced after surgery. Thus, therapies aimed to restore a proper endothelial function before and after surgical repair could benefit MVP patients
DOI: 10.5281/zenodo.3709363
title: Dataset related to article "Nivolumab in disadvantaged subgroups of metastatic non-small-cell lung cancer patients: a single-institution experience."

description: <strong>Aim:</strong> Immunotherapy opened new frontiers in metastatic non-small-cell lung cancer treatment, but not all patients benefit from it. <strong>Methods:</strong> We retrospectively evaluated 65 metastatic non-small-cell lung cancer patients, treated with nivolumab, considering as disadvantaged subgroups those with poor performance status, elderly, patients with brain metastases at baseline, with high disease burden and refractory to platinum. <strong>Results:</strong> No differences in overall survival or time to treatment failure were found according to performance status, age, presence of brain metastases at baseline or high disease burden. Conversely, patients refractory to platinum had a statistically significant shorter overall survival and time to treatment failure. At multivariate analysis only platinum resistance was confirmed as an independent predictive factor. <strong>Conclusion:</strong> Our study suggests that only refractoriness to platinum salts influence the efficacy of nivolumab.
DOI: 10.5281/zenodo.3709364
title: Dataset related to article "Nivolumab in disadvantaged subgroups of metastatic non-small-cell lung cancer patients: a single-institution experience."

description: <strong>Aim:</strong> Immunotherapy opened new frontiers in metastatic non-small-cell lung cancer treatment, but not all patients benefit from it. <strong>Methods:</strong> We retrospectively evaluated 65 metastatic non-small-cell lung cancer patients, treated with nivolumab, considering as disadvantaged subgroups those with poor performance status, elderly, patients with brain metastases at baseline, with high disease burden and refractory to platinum. <strong>Results:</strong> No differences in overall survival or time to treatment failure were found according to performance status, age, presence of brain metastases at baseline or high disease burden. Conversely, patients refractory to platinum had a statistically significant shorter overall survival and time to treatment failure. At multivariate analysis only platinum resistance was confirmed as an independent predictive factor. <strong>Conclusion:</strong> Our study suggests that only refractoriness to platinum salts influence the efficacy of nivolumab.