cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.17632/ngrxz5kphv.1
title: Surfactant proteins changes after acute hemodynamic improvement in patients with advanced chronic heart failure treated with Levosimendan

description: Alveolar-capillary membrane evaluated by carbon monoxide diffusion (DLCO) plays an important role in heart failure (HF). Surfactant Proteins (SPs) have also been suggested as a worthwhile marker. In HF, Levosimendan improves pulmonary hemodynamics and reduces lung fluids but associated SPs and DLCO changes are unknown. Sixty-five advanced HF patients underwent spirometry, cardiopulmonary exercise test (CPET) and SPs determination before and after Levosimendan. Levosimendan caused natriuretic peptide-B (BNP) reduction, peakVO2 increase and VE/VCO2 slope reduction. Spirometry improved but DLCO did not. SP-A, SP-D and immature SP-B reduced (73.7±25.3 vs. 66.3±22.7ng/mL*, 247±121 vs. 223±110ng/mL*, 39.4±18.7 vs. 34.4±17.9AU*, respectively); while mature SP-B increased (424±218 vs. 461±243ng/mL, *=p&lt;0.001). Spirometry, BNP and CPET changes suggest hemodynamic improvement and lung fluid reduction. SP-A, SP-D and immature SP-B reduction indicates a reduction of inflammatory stress; conversely mature SP-B increase suggests alveolar cell function restoration. In conclusion, acute lung fluid reduction is associated with SPs but not DLCO changes. SPs are fast responders to alveolar-capillary membrane condition changes.
DOI: 10.17632/nzcd7wr2g2.1
title: Standard Calibration Curve

description: Standard Calibration Curve
DOI: 10.17632/r7syzz3xkr.1
title: Pten-NOLC1 Fusion Promotes C-MET and EGFR Signaling in Human Cancers (RNAseq Sample TP10S0638T)
DOI: 10.17632/d6yd4rb6t6.2
title: Natriuretic peptide B plasma concentration increases in the first 12 h of pulmonary edema recovery

description: BACKGROUND: According to guidelines, single determination of B-type Natriuretic peptide (BNP) should be used for distinguishing between cardiac and non-cardiac acute dyspnea at the emergency room. BNP measurement is also recommended before hospital discharge in patients hospitalized for heart failure to assess prognosis and to evaluate treatment efficacy. In acute cardiogenic pulmonary edema, BNP is measured using a single BNP determination, but the temporal behavior of BNP during pulmonary edema recovery is unknown. METHODS: Fifty chronic low ejection fraction (&lt;40%) heart failure patients (age 77 ± 9 years, 17 M-33F) admitted for acute pulmonary edema were studied. Patients were grouped according to 50% dyspnea recovery time into 3 groups: ≤30 min (n = 14), 30 to 60 min (n = 19), and &gt; 60 min (n = 17). BNP was measured at arrival and 4, 8, 12 and 24 h afterwards. RESULTS: At arrival, BNP was elevated in all patients without significant difference among groups. In the entire population, BNP median and interquartile range value were 791 (528-1327) pg/ml, 785(559-1299) pg/ml, 1014(761-1573) pg/ml, 1049(784-1412) pg/ml, 805(497-1271) pg/ml at arrival and 4, 8, 12 and 24 h afterwards, respectively, showing higher values at 8 and 12 h. This peculiar temporal behavior of BNP was shared by all study groups. Patients with the longest edema resolution showed the highest BNP level 8 and 12 h after admission. CONCLUSIONS: In acute pulmonary edema, BNP increased up to 12 h after emergency admission regardless of dyspnea recovery time, making BNP quantitative meaning in the acute phase of pulmonary edema uncertain.
DOI: 10.17632/hxywjs5nv5.1
title: Pten-NOLC1 Fusion Promotes C-MET and EGFR Signaling in Human Cancers (RNAseq Sample TP12S0340T)
DOI: 10.17632/pcx7mj68yn.1
title: Image Datasets of Cocoa Beans for Taxonomy Nuances Evaluation

description: To be written.
DOI: 10.17632/ww45mxt36t.1
title: 2018 - 30541573

description: To date the TGF-β1 activation mediated by integrin ανβ5 during fibrosis is well-known. This process has been shown also in the heart, where cardiac fibroblasts (CF) differentiate into α-smooth muscle actin (α-SMA)-positive myofibroblasts (MyoFB). Here, we studied the effects on CF, isolated by spontaneously hypertensive rats (SHR), of integrin ανβ5 inhibition in MyoFB differentiation. Staining and immunohistochemistry were performed on rat cardiac tissue. CF were isolated by enzymatic digestion from SHR (SHR-CF) and normotensive WKY (WKY-CF) rat hearts and then treated for in vitro evaluation. SHR heart tissues revealed a higher TGF-β1 expression vs. WKY samples. SHR-CF showed an enhanced SMAD2/3 activation and an up-regulated expression of α-SMA, a typical MyoFB marker, especially after TGF-β1 treatment. Immunostaining on cardiac tissues revealed a higher expression of integrin ανβ5 in SHR vs. WKY rat hearts. In vitro results confirmed the up-regulation of integrin ανβ5 expression in SHR-CF at basal condition and after TGF-β1 treatment, in comparison with WKY-CF. Inhibition of integrin ανβ5 by cilengitide treatment led a decreased expression of ανβ5, collagen I, and α-SMA in SHR-CF vs. WKY-CF, resulting in a diminished differentiation of CF into MyoFB. Taking together, results suggested that SHR-CF are more susceptible to TGF-β1, showing an up-regulated activation of SMAD2/3 signaling, and an increased ανβ5, α-SMA, and collagen I expression. Hypertension stimulus promoted an up-regulation of integrin ανβ5 on SHR cardiac tissue and its in vitro inhibition reverted pro-fibrotic events of SHR-CF. Inhibition of integrin ανβ5 exerted by cilengitide strongly diminished SHR-CF differentiation into detrimental MyoFB. So, integrin ανβ5 might be considered a novel therapeutic target and cilengitide an effective pharmacological tool to limit the progression of hypertension-induced cardiac fibrosis.
DOI: 10.5281/zenodo.3455577
title: weecology/forecasts 2019-09-20

description: Archived forecasts for future analysis
DOI: 10.17632/2rhzf6zwz4.1
title: Mineralocorticoid receptor antagonists for heart failure: a real life observational study

description: Aims. Mineralocorticoid receptor antagonists (MRA) have been demonstrated to improve outcomes in reduced ejection fraction heart failure patients (HFrEF). However, MRA added to conventional treatment may lead to worsening of renal function and hyperkalaemia. We investigated, in a population-based analysis, the long-term effects of MRA treatment in HFrEF patients. Methods and Results. We analyzed 6046 patients data included in the Metabolic Exercise Cardiac Kidney Index (MECKI) score data-set. Analysis was performed in patients treated (n=3163) and not treated (n=2883) with MRA. Study endpoint was composite of cardiovascular death, urgent heart transplantation or left ventricular assist device implantation. Ten years survival was analyzed through Kaplan Meier, compared by Log-Rank test and propensity score matching. At 10 years follow-up MRA not treated group had significantly lower number of events than MRA treated group (p&lt;0.001).MRA treated patients had more severe HF (higher NYHA class and lower left ventricular ejection fraction, kidney function and peakVO2). At propensity score matching analysis performed on 1587 patients, MRA treated and not treated patients showed similar study endpoint values. Conclusion. In conclusion, MRA treatment does not affect the composite of cardiovascular death, urgent heart transplantation or left ventricular assist device implantation, in a real life setting. A meticulous patients follow-up, as done in trials, is likely needed to match the positive MRA-related benefits observed in clinical trials.
DOI: 10.17632/pcx7mj68yn.2
title: Image Datasets of Cocoa Beans for Taxonomy Nuances Evaluation

description: To be written.
DOI: 10.17632/wpb5fx6x6g.3
title: The Quantitative Relationship Between North Central Florida Ambient Soundscapes and Landscape Development Intensity

description: The soundscapes of each site were sampled using a Fostex fr-2le field recorder and a Seinheisser ME 62 omni-directional microphone. The recordings were 30 minutes long and used a waveform format with a 24-bit depth and 48 kHz sampling rate. The recordings took place between 0900 and 1000 on week days over two years from April 2013 until March 2015. This time of day was selected for its ambient nature, avoiding known times of increased acoustic activity like dawn chorus or early morning rush hour traffic. A tripod ensured that the recording equipment was consistently 1 meter off the ground. Recordings were not taken if the wind in the area exceeded 10 mph or if it was raining. At each site, climatic conditions were documented at the time of the recording. This information was taken from real time data available online from the closest weather station. Temperature and relative humidity were confirmed on site with a psychrometer. The location of the recording was documented with a handheld GPS unit. The acoustic analysis of the data utilized different divisions of the frequency spectrum to describe the soundscapes. First, the total sampled frequency spectrum (20-20,000 Hz) was analyzed as a whole. Second, each site’s spectrogram was divided into twenty, 1 kHz wide frequency bands. The lowest frequency band ranged from 20-1000 Hz to accommodate for the frequency limits of the microphone used. Third, the two frequency regions attributed to anthropogenic and biologic sourced sounds (anthrophony, 20-2000 Hz and biophony, 2000-8000 Hz) were analyzed. The acoustic metrics used in this study to describe the soundscapes were calculated from spectrograms made with Raven Pro 1.4 (Cornell University, Ithaca, New York) software. The spectrograms used a Hann window with a discrete Fourier Transform size of 256 samples and 188 Hz grid size. The metrics were based on the power spectral density (PSD), the amount of sound power per unit frequency (dB/Hz), of the frequency-time bins in the spectrogram, which was calculated internally within Raven using Fourier Transforms (see Figure 2). Five different metrics were calculated using the PSD values from each recording: inband power, average PSD, delta power, aggregate entropy, and center frequency.
DOI: 10.17632/wpb5fx6x6g.4
title: The Quantitative Relationship Between North Central Florida Ambient Soundscapes and Landscape Development Intensity

description: The soundscapes of each site were sampled using a Fostex fr-2le field recorder and a Seinheisser ME 62 omni-directional microphone. The recordings were 30 minutes long and used a waveform format with a 24-bit depth and 48 kHz sampling rate. The recordings took place between 0900 and 1000 on week days over two years from April 2013 until March 2015. This time of day was selected for its ambient nature, avoiding known times of increased acoustic activity like dawn chorus or early morning rush hour traffic. A tripod ensured that the recording equipment was consistently 1 meter off the ground. Recordings were not taken if the wind in the area exceeded 10 mph or if it was raining. At each site, climatic conditions were documented at the time of the recording. This information was taken from real time data available online from the closest weather station. Temperature and relative humidity were confirmed on site with a psychrometer. The location of the recording was documented with a handheld GPS unit. The acoustic analysis of the data utilized different divisions of the frequency spectrum to describe the soundscapes. First, the total sampled frequency spectrum (20-20,000 Hz) was analyzed as a whole. Second, each site’s spectrogram was divided into twenty, 1 kHz wide frequency bands. The lowest frequency band ranged from 20-1000 Hz to accommodate for the frequency limits of the microphone used. Third, the two frequency regions attributed to anthropogenic and biologic sourced sounds (anthrophony, 20-2000 Hz and biophony, 2000-8000 Hz) were analyzed. The acoustic metrics used in this study to describe the soundscapes were calculated from spectrograms made with Raven Pro 1.4 (Cornell University, Ithaca, New York) software. The spectrograms used a Hann window with a discrete Fourier Transform size of 256 samples and 188 Hz grid size. The metrics were based on the power spectral density (PSD), the amount of sound power per unit frequency (dB/Hz), of the frequency-time bins in the spectrogram, which was calculated internally within Raven using Fourier Transforms (see Figure 2). Five different metrics were calculated using the PSD values from each recording: inband power, average PSD, delta power, aggregate entropy, and center frequency.
DOI: 10.17632/x32tccm5kt.1
title: Table S1 (inc. WT and E19-22 mutants)

description: The table includes all the data, including WT vs no tagged control, and each of the 4 E19-22 mutants vs WT.
DOI: 10.17632/x32tccm5kt.2
title: Table S1 (inc. WT and E19-22 mutants)

description: The table includes all the data, including WT vs no tagged control, and each of the 4 E19-22 mutants vs WT.
DOI: 10.17632/bz9242f2k4.1
title: Pten-NOLC1 Fusion Promotes C-MET and EGFR Signaling in Human Cancers (RNAseq Sample TP12S0790T)
DOI: 10.17632/hn8ttp5s8y.1
title: Carbon and phosphorus processing in a carbonate karst aquifer and delivery to the coastal ocean

description: In siliciclastic systems, submarine groundwater discharge (SGD) provides a fraction of freshwater and nutrients delivered to coastal waters, but in many carbonate karst terrains SGD represents the predominant source of terrestrial water and solutes. Solute concentrations may be strongly modified by reactions in subterranean estuaries, altering chemical fluxes via SGD. In carbonate settings, feedbacks between organic carbon remineralization and calcium carbonate mineral (CaCO3) dissolution and precipitation may alter carbon dioxide (CO2) and phosphorus (P) concentrations and fluxes associated with SGD. To assess these effects, we sampled water from multiple submarine springs along the east coast of the Yucatan peninsula, as well as inland cenotes, and a coastal groundwater well. We measured ammonium (NH4), phosphate (PO4), major element, dissolved inorganic and organic carbon concentrations (DIC and DOC), fluorescent characteristics of colored dissolved organic matter (CDOM) and modeled calcite saturation indices (SIcal) and the partial pressure of dissolved CO2 (PCO2). These data indicate that reactions along a hypothetical flow path to the coast control the composition of terrestrial fresh water entering the subterranean estuary. Non-conservative mixing between brackish groundwater and lagoon water show that CaCO3 dissolution and CO2 production from organic matter remineralization occur within the subterranean estuary. Although both organic matter remineralization and carbonate dissolution should liberate P, molar N:P ratios in spring discharge are higher than the Redfield Ratio of 16:1, suggesting net sequestration of remineralized P through sorption to carbonate minerals within the STE. This result indicates that SGD, the primary source of water and nutrient to this coastal zone, results in P limitation in coastal water and is a source of CO2 despite the buffering effects CaCO3 dissolution. This result also emphasizes the importance of biogeochemical reactions within subterranean estuaries for estimates of local and global impacts of SGD composition on solute delivery to the oceans.
DOI: 10.17632/nsr52pwd6f.1
title: Transplanting Cells from Old but Not Young Donors Causes Physical Dysfunction in Older Recipients

description: Adipose-derived mesenchymal stem cell (ADSC)-based regenerative therapies have shown potential for use in many chronic diseases. Aging diminishes stem cell regenerative potential, yet it is unknown whether stem cells from aged donors cause adverse effects in recipients. ADSCs can be obtained using minimally invasive approaches and possess low immunogenicity. Nevertheless, we found that transplanting ADSCs from old donors, but not those from young donors, induces physical dysfunction in older recipient mice. Using single cell transcriptomic analysis, we identified a naturally occurring senescent cell population in ADSCs primarily from old donors that resembles in vitro-generated senescent cells with regard to a number of key pathways. Our study reveals a previously unrecognized health concern due to ADSCs from old donors and lays the foundation for a new avenue of research to devise interventions to reduce harmful effects of ADSCs from old donors.
DOI: 10.17632/pcx7mj68yn.3
title: Image Datasets of Cocoa Beans for Taxonomy Nuances Evaluation

description: Six image datasets of cut-test-classified cocoa beans were created from the research presented in [FelipeAntunes_Dissertation_PPGMC.pdf]. Each dataset contains 14 classes (namely: Compartmentalized Brown, Compartmentalized White, Compartmentalized Partially Purple, Compartmentalized Purple, Compartmentalized Slatty, Plated Brown, Plated White, Plated Partially Purple, Plated Purple, Plated Slatty, Moldered, Flattened, Brittle and Agglutinated) with 100 images per class, totaling 1400 images per dataset. Those bases were created to evaluate nuances in classification methods. The source dataset from which those images were derived is present in [An_Image_Dataset_of_Cut-Test-Classified_Cocoa_Beans.pdf].
DOI: 10.17632/pcx7mj68yn.4
title: Image Datasets of Cocoa Beans for Taxonomy Nuances Evaluation

description: Six image datasets of cut-test-classified cocoa beans were created from the research presented in [FelipeAntunes_Dissertation_PPGMC.pdf]. Each dataset contains 14 classes (namely: Compartmentalized Brown, Compartmentalized White, Compartmentalized Partially Purple, Compartmentalized Purple, Compartmentalized Slatty, Plated Brown, Plated White, Plated Partially Purple, Plated Purple, Plated Slatty, Moldered, Flattened, Brittle and Agglutinated) with 100 images per class, totaling 1400 images per dataset. Those bases were created to evaluate nuances in classification methods. The source dataset from which those images were derived is present in [An_Image_Dataset_of_Cut-Test-Classified_Cocoa_Beans.pdf].
DOI: 10.5281/zenodo.3455572
title: weecology/portalPredictions 2019-09-20

description: Using various models to forecast abundances at Portal
DOI: 10.17632/7ydfs62gd6.1
title: Data for report "Artificial Intelligence: How knowledge is created, transferred, and used"

description: There are the underlying data for our report "Artificial Intelligence: How knowledge is created, transferred, and used", published 2018. Data can be used to construct the graphs used in the report.
DOI: 10.17632/3hjbmj4z2x.1
title: Morphology and phylogeny of Caudotestis dobrovolski n. sp.

description: The 28S rRNA genes alignment of several Trematoda families for investigation of the phylogeny of the Xiphidiata incertae sedis, including Caudotestis dobrovolski n. sp., see: Sokolov S., Lebedeva D., Shchenkov S., Gordeev I. Caudotestis dobrovolski n. sp. (Trematoda, Xiphidiata) in North Pacific scorpaeniform fish: a crisis of concept of the opecoelid subfamily Stenakrinae Yamaguti, 1970
DOI: 10.17632/fn995665hj.1
title: Profile of Accident Cases Attending the University of Port Harcourt Teaching Hospital, Nigeria

description: Background: Accidents have probably happened since the first caveman lit the first fire. This study profiled accidents cases handled at the Accident and Emergency Department (AED) of University of Port Harcourt Teaching Hospital (UPTH), Nigeria from 1st January, 2013 to 31st December, 2017. Materials and Methods: Sequel to obtaining Ethical Clearance, data were extracted from the AED patients' register by systematic sampling. Results: Socio-demographics showed 68.8% of accident victims were male and 31.2% female just as most (31.4%) were within the 21-30-year age bracket. Also, most accidents occurred in January (12.3%), April (12.6%) and December (9.6%) - mainly festive periods in especially the Southern part of the country. Road Traffic Accidents topped the list at 67.9% just as head injury occurred more frequently than multiple body region injury. Conclusion: Road Traffic Accidents remain the leading cause of presentation of accident victims to the A & E of UPTH and involved the youth and energetic work force with festive periods accounting for sudden rises, it recommended that more road health and safety education be carried by all concerned parties especially the Government while also increasing monitoring and enforcement of traffic rules on our roads. The register of AED` in the UPTH and Nigerian hospitals in general needs to be upgraded to the use of computer software to build a database for easy accessibility and better preservation of records
DOI: 10.17632/rbz5rkv97f.2
title: MODELO DE AVALIAÇÃO DE DESEMPENHO DE COOPERATIVAS DE CRÉDITO: UM ESTUDO BASEADO NA ANÁLISE FATORIAL EXPLORATÓRIA

description: Este estudo tem como objetivo principal realizar a análise fatorial exploratória, para identificar as variáveis mais relevantes a fim de compor um modelo de avaliação de desempenho, para as cooperativas de crédito do Brasil. Utilizando dados dos relatórios financeiros de 1090 cooperativas de crédito do ano de 2015. Para tal, foi desenvolvido um estudo descritivo e quantitativo e aplicado a análise fatorial exploratória. Na análise dos resultados foi possível identificar que das 15 variáveis iniciais, propostas pelos autores por meio de uma revisão de literatura, 12 se mostraram adequadas e relevantes para a formulação do modelo sendo elas: Ativo total; Despesas com pessoal; Imobilização; ROA; ROE; Capital; Capitalização; Cobertura voluntária; Despesas Administrativas; Despesas operacionais totais; Liquidez geral e Volume de crédito. Também foi possível agrupar as variáveis em 5 fatores denominados de: despesas, desempenho financeiro, liquidez, solvência e bens e direitos, estes fatores são responsáveis por explicar 63,891% da variância total dos dados.
DOI: 10.17632/mkbk9cwkdw.1
title: Gatum_01

description: gatum version 01
DOI: 10.17632/n2f48fyynb.1
title: DEFORM SUBROUTINE

description: Deform subroutine
DOI: 10.17632/p5jv2br9dm.1
title: acute kidney injury in MIMIC

description: we only included the data from the first ICU admission of each adult patients. And we excluded patients if who 1) stayed in ICU less than 24 hours, 2) missed key data (serum creatinine, urine output, neutrophil, lymphocyte or platelet) and 3) without AKI. The identification of AKI was based on the Kidney Disease: Improving Global Outcomes (KDIGO) guideline: urine output less than 0.5 ml/kg/hour for 6 hours, or serum creatinine (SCr) increases ≥0.3 mg/dl within 48 hours or increases ≥1.5 times baseline value within 7 days. Demographic information included age, sex, ethnicity, care unit and body mass index (BMI). Laboratory measurements included leukocyte, neutrophil, lymphocyte, erythrocyte, hemoglobin (Hb), red cell distribution width (RDW), platelet, blood glucose, SCr, blood urea nitrogen (BUN), serum sodium, serum potassium, serum chloride, serum pH, bicarbonate, partial pressure of oxygen (PO2) and partial pressure of carbon dioxide (PCO2) over the first 24 hours into the ICU. And Sequential Organ Failure Assessment (SOFA) score, Simplified Acute Physiology Score II (SAPSII) and comorbidity were also extracted over the first 24 hours.