cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.7899431
title: Farm animals against open borders: uncovering discrepancies between narratives and evidence regarding actors and motives in the animal trade

description: ABSTRACT: The paper examined dominant discourses in the debate about live animal transport and trade before reviewing trade figures from the UN Comtrade database. Between 1998 and 2015, the trade in cattle increased slightly, the trade in pigs increased by 76%, while the trade in poultry increased more than doubled. It is shown that an increased division of work is the driving force behind animal trade and that not even animal advocacy groups are effective in reducing the amount of trade. Largely independent of the ethical framework applied, in an environment that pays increasingly tribute to animal welfare, this is problematic. The paper concluded that animal trade results in externalities that should be internalized by governments.
DOI: 10.6084/m9.figshare.7899434
title: Comparative efficacy and safety of the left versus right radial approach for percutaneous coronary procedures: a meta-analysis including 6870 patients

description: The radial approach is widely used in the treatment of patients with coronary artery disease. We conducted a meta-analysis of published results on the efficacy and safety of the left and right radial approaches in patients undergoing percutaneous coronary procedures. A systematic search of reference databases was conducted, and data from 14 randomized controlled trials involving 6870 participants were analyzed. The left radial approach was associated with significant reductions in fluoroscopy time [standardized mean difference (SMD)=-0.14, 95% confidence interval (CI)=-0.19 to -0.09; P&lt;0.00001] and contrast volume (SMD=-0.07, 95%CI=-0.12 to -0.02; P=0.009). There were no significant differences in rate of procedural failure of the left and the right radial approaches [risk ratios (RR)=0.98; 95%CI=0.77-1.25; P=0.88] or procedural time (SMD=-0.05, 95%CI=0.17-0.06; P=0.38). Tortuosity of the subclavian artery (RR=0.27, 95%CI=0.14-0.50; P&lt;0.0001) was reported more frequently with the right radial approach. A greater number of catheters were used with the left than with the right radial approach (SMD=0.25, 95%CI=0.04-0.46; P=0.02). We conclude that the left radial approach is as safe as the right radial approach, and that the left radial approach should be recommended for use in percutaneous coronary procedures, especially in percutaneous coronary angiograms.
DOI: 10.6084/m9.figshare.7899440.v1
title: Prognostic significance of the dynamic changes of systemic inflammatory response in metastatic renal cell carcinoma

description: ABSTRACT Purpose: To elucidate the prognostic value of systemic inflammatory response in patients with metastatic renal cell carcinoma (mRCC) who are treated with sunitinib, we evaluated the prognostic role of C-reactive protein (CRP) kinetics. This study also compared prognostic models containing CRP kinetics and neutrophil-to-lymphocyte ratio (NLR) kinetics. Materials and Methods: A consecutive cohort of 94 patients with mRCC who were treated with sunitinib was retrospectively included from Fudan University Shanghai Cancer Center. According to dynamic changes in CRP and the NLR, patients were divided into three groups for analysis of CRP and NLR kinetics. The associations between survival and potential prognostic factors were assessed. The incremental value of prognostication was evaluated. Results: A significant difference (P&lt;0.001) in overall survival (OS) was observed among the three groups of CRP kinetics. The median OS of the non-elevated group was nearly 1.3-fold longer than that of the normalized group (33.0 vs. 26.3 months), and two times longer than that of the non-normalized group (33.0 vs. 14.0 months). Multivariate analysis showed that CRP and NLR kinetics were independent prognostic indicators. The model containing CRP kinetics had a better predictive accuracy than that with NLR kinetics, which was supported by the C-index (0.731 vs. 0.684) and the likelihood ratio χ2 test (79.9% vs. 44.9%). Conclusion: Our study suggests that dynamic changes in CRP can better predict survival in patients with mRCC who are treated with sunitinib. Routine assessment of CRP before and after targeted therapy would help identify patients at risk of a poor outcome.
DOI: 10.6084/m9.figshare.7899443.v1
title: Effect of Preoperative Creatinine Levels on Mortality after Coronary Artery Bypass Grafting Surgery: an Observational Study

description: Abstract Introduction: Renal function is an independent risk factor for mortality among on-pump coronary bypass grafting (ONCABG) patients. This association is well known in the international literature, but there is a lack of knowledge of how admission creatinine (AC) levels modulate each cardiovascular risk factor. Objective: The aim of this paper was to assess the effect of different AC levels on mortality among ONCABG patients. Methods: 1,599 patients who underwent ONCABG between December 1999 and February 2006 at Hospital de Base in São José do Rio Preto/SP-Brazil were included. They were divided into quartiles according to their AC levels (QI: 0.2 ≤AC &lt; 1.0 mg/dL; QII: 1.0 ≤ AC &lt; 1.2 mg/dL; QIII: 1.2 ≤ AC &lt; 1.4 mg/dL; and QIV: 1.4 ≤ AC ≤ 2.6 mg/dL). Seven risk factors were then evaluated in each stratum. Results: Mortality was higher in the QIV group than QI or QII groups. Factors such as age (≥ 65 years) and cardiopulmonary bypass (CPB) time (≥ 115 minutes) in QIV, as well preoperative hospital stay (≥ 5 days) in QIII, were associated with higher mortality rates. Creatinine variation greater than or equal to 0.4 mg/dL increased mortality rates in all groups. The use of intra-aortic balloon pump and dialysis increased mortality rates in all groups except for QII. Type I neurological dysfunction increased the mortality rate in the QII and III groups. Conclusion: Creatinine levels play an important role in ONCABG mortality. The combination of selected risk factors and higher AC values leads to a worse prognosis. On the other hand, lower AC values were associated with a protective effect, even among elderly patients and those with a high CPB time.
DOI: 10.6084/m9.figshare.7899425
title: Inflammation and oxidative stress in heart failure: effects of exercise intensity and duration

description: Although acute exercise is apparently pro-inflammatory and increases oxidative stress, it can promote the necessary stress stimulus to train chronic adaptations in patients with chronic heart failure (CHF). This study aimed to compare the effects of exercise intensity and duration on the inflammatory markers soluble tumor necrosis factor receptor (sTNFR1) and interleukin-6 (IL-6), and on oxidative stress [malondialdehyde (MDA) and antioxidant enzymes: catalase (CAT) and superoxide dismutase (SOD)] in individuals with CHF. Eighteen patients performed three exercise sessions: 30 min of moderate-intensity (M30) exercise, 30 min of low-intensity (L30) exercise, and 45 min of low-intensity (L45) exercise. Blood analysis was performed before exercise (baseline), immediately after each session (after), and 1 h after the end of each session (1h after). Thirty min of M30 exercise promoted a larger stressor stimulus, both pro-inflammatory and pro-oxidative, than that promoted by exercises L30 and L45. This was evidenced by increased sTNFR1 and MDA levels after exercise M30. In response to this stressor stimulus, 1 h after exercise, there was an increase in IL-6 and CAT levels, and a return of sTNFR1 to baseline levels. These findings suggest that compared with the duration of exercise, the exercise intensity was an important factor of physiologic adjustments.
DOI: 10.6084/m9.figshare.7899428
title: Effect of strontium ranelate on pain behavior in an experimental model of osteoarthritis

description: Strontium ranelate (SrRan) is a drug usually prescribed to treat osteoporosis, with proven effects of decreasing the risk of fractures and an indication of reducing the progression of osteoarthritis (OA). This study aimed to investigate the effects of SrRan as either a prophylactic or a treatment drug, using an OA rat model to assess pain behavior. A monoiodoacetate (MIA)-induced knee joint OA model in Wistar rats was used. Thirty Wistar rats (both sexes, 60 days old) were distributed in five groups of 6 rats each: the control group, that received no intervention; a prophylactic group, that received oral administration of 25 mg·kg-1·day-1 of SrRan for 28 days before induction of OA; a group treated with 25 mg·kg-1·day-1 of SrRan for 28 days after OA induction; a group treated with 50 mg·kg-1·day-1 during 28 days after OA induction; and a group that received oral saline for 28 days after induction. The assessment of pain behavior was performed considering articular incapacitation (weight-bearing test), mechanical hyperalgesia (Randall Selitto test) and motor activity (rotarod test), on days 0, 7, 14, 21, and 28. This experiment did not yield a significant difference when comparing the group that received SrRan prophylactically with the groups treated with 25 or 50 mg·kg-1·day-1 and the group that received oral saline. Thus, SrRan did not provide analgesia in either treated rats or as a prophylactic drug with the tested doses. Higher doses should be tested further to achieve possible significant results.
DOI: 10.6084/m9.figshare.7899434.v1
title: Comparative efficacy and safety of the left versus right radial approach for percutaneous coronary procedures: a meta-analysis including 6870 patients

description: The radial approach is widely used in the treatment of patients with coronary artery disease. We conducted a meta-analysis of published results on the efficacy and safety of the left and right radial approaches in patients undergoing percutaneous coronary procedures. A systematic search of reference databases was conducted, and data from 14 randomized controlled trials involving 6870 participants were analyzed. The left radial approach was associated with significant reductions in fluoroscopy time [standardized mean difference (SMD)=-0.14, 95% confidence interval (CI)=-0.19 to -0.09; P&lt;0.00001] and contrast volume (SMD=-0.07, 95%CI=-0.12 to -0.02; P=0.009). There were no significant differences in rate of procedural failure of the left and the right radial approaches [risk ratios (RR)=0.98; 95%CI=0.77-1.25; P=0.88] or procedural time (SMD=-0.05, 95%CI=0.17-0.06; P=0.38). Tortuosity of the subclavian artery (RR=0.27, 95%CI=0.14-0.50; P&lt;0.0001) was reported more frequently with the right radial approach. A greater number of catheters were used with the left than with the right radial approach (SMD=0.25, 95%CI=0.04-0.46; P=0.02). We conclude that the left radial approach is as safe as the right radial approach, and that the left radial approach should be recommended for use in percutaneous coronary procedures, especially in percutaneous coronary angiograms.
DOI: 10.6084/m9.figshare.7899419
title: Consumer behavior: conditioners on the purchase decision of fluid milk

description: ABSTRACT: Considering economic, contingent and cultural conditions that interfere with consumer demand, the objective of this research was to evaluate the degree of importance of these variables in the decision of the Brazilian consumer to buy fluid milk. A total 1,015 milk consumers were sampled through non-probabilistic tools such as researchers’ contact network, snowballing, and self-generated samples, in a virtual questionnaire. Non-parametric tests and univariate statistical analyzes were applied, including the chi-square test. The consumer profile interferes with the selection criteria in the purchase of fluid milk as follows: (a) women consider “price”, “product origin”, “friend recommendation”, “product appearance”, “sales offers”, and “brand” as the most important conditioners; (b) young people, aged between 18 and 25, consider “product origin” a less important attribute; (c) consumers over 45 years of age value “price” the less; (d) consumers with incomes of up to one minimum wage value “sales offers” the most. This research theoretically confirmed the hypothesis that prior information regarding milk production, especially brands, lead the decision to buy fluid milk, especially in women case. Product price and availability are complementary constraints.
DOI: 10.6084/m9.figshare.7899422
title: BIOSOLIDS AS SUBSTRATE FOR THE PRODUCTION OF CEIBA SPECIOSA SEEDLINGS

description: ABSTRACT Biosolids is a problematic residual issue in Brazil and other developing countries, where it is common to discard this material in landfills and/or open dumps. However, biosolids can be recycled in agricultural and forestry activities, considering they have high contents of organic matter and nutrients. Therefore, their application in substrates to produce forest seedlings can be beneficial. The scope of this study is to evaluate substrates with different proportions of biosolids and coconut fiber in the growth and quality of seedlings of Ceiba speciosa (A. St.-Hil.) Ravenna, a native species from South America that is largely used for landscaping and forest restoration. There were studied substrates with proportions varying between 25 to 100% of biosolids and 75 to 0% of coconut fiber to produce seedlings in containers (plastic tubes with 280 cm³). At 120 days after sowing, it was measured the growth, biomass and quality of the seedlings. In general aspects, the higher the proportion of biosolids in the substrate, the higher were the growth, biomass and quality. The biosolids favored the growth in shoot height and biomass more than in diameter and root biomass. Considering the positive results and the possibility of recycling biosolids, it is recommended the use of substrates containing from 50 to 100% of biosolids to produce Ceiba speciosa seedlings in 280 cm³ plastic tubes.
DOI: 10.6084/m9.figshare.7899425.v1
title: Inflammation and oxidative stress in heart failure: effects of exercise intensity and duration

description: Although acute exercise is apparently pro-inflammatory and increases oxidative stress, it can promote the necessary stress stimulus to train chronic adaptations in patients with chronic heart failure (CHF). This study aimed to compare the effects of exercise intensity and duration on the inflammatory markers soluble tumor necrosis factor receptor (sTNFR1) and interleukin-6 (IL-6), and on oxidative stress [malondialdehyde (MDA) and antioxidant enzymes: catalase (CAT) and superoxide dismutase (SOD)] in individuals with CHF. Eighteen patients performed three exercise sessions: 30 min of moderate-intensity (M30) exercise, 30 min of low-intensity (L30) exercise, and 45 min of low-intensity (L45) exercise. Blood analysis was performed before exercise (baseline), immediately after each session (after), and 1 h after the end of each session (1h after). Thirty min of M30 exercise promoted a larger stressor stimulus, both pro-inflammatory and pro-oxidative, than that promoted by exercises L30 and L45. This was evidenced by increased sTNFR1 and MDA levels after exercise M30. In response to this stressor stimulus, 1 h after exercise, there was an increase in IL-6 and CAT levels, and a return of sTNFR1 to baseline levels. These findings suggest that compared with the duration of exercise, the exercise intensity was an important factor of physiologic adjustments.
DOI: 10.6084/m9.figshare.7899428.v1
title: Effect of strontium ranelate on pain behavior in an experimental model of osteoarthritis

description: Strontium ranelate (SrRan) is a drug usually prescribed to treat osteoporosis, with proven effects of decreasing the risk of fractures and an indication of reducing the progression of osteoarthritis (OA). This study aimed to investigate the effects of SrRan as either a prophylactic or a treatment drug, using an OA rat model to assess pain behavior. A monoiodoacetate (MIA)-induced knee joint OA model in Wistar rats was used. Thirty Wistar rats (both sexes, 60 days old) were distributed in five groups of 6 rats each: the control group, that received no intervention; a prophylactic group, that received oral administration of 25 mg·kg-1·day-1 of SrRan for 28 days before induction of OA; a group treated with 25 mg·kg-1·day-1 of SrRan for 28 days after OA induction; a group treated with 50 mg·kg-1·day-1 during 28 days after OA induction; and a group that received oral saline for 28 days after induction. The assessment of pain behavior was performed considering articular incapacitation (weight-bearing test), mechanical hyperalgesia (Randall Selitto test) and motor activity (rotarod test), on days 0, 7, 14, 21, and 28. This experiment did not yield a significant difference when comparing the group that received SrRan prophylactically with the groups treated with 25 or 50 mg·kg-1·day-1 and the group that received oral saline. Thus, SrRan did not provide analgesia in either treated rats or as a prophylactic drug with the tested doses. Higher doses should be tested further to achieve possible significant results.
DOI: 10.6084/m9.figshare.7899431.v1
title: Farm animals against open borders: uncovering discrepancies between narratives and evidence regarding actors and motives in the animal trade

description: ABSTRACT: The paper examined dominant discourses in the debate about live animal transport and trade before reviewing trade figures from the UN Comtrade database. Between 1998 and 2015, the trade in cattle increased slightly, the trade in pigs increased by 76%, while the trade in poultry increased more than doubled. It is shown that an increased division of work is the driving force behind animal trade and that not even animal advocacy groups are effective in reducing the amount of trade. Largely independent of the ethical framework applied, in an environment that pays increasingly tribute to animal welfare, this is problematic. The paper concluded that animal trade results in externalities that should be internalized by governments.
DOI: 10.6084/m9.figshare.7899410
title: Seroprevalence of Toxoplasma gondii and Leishmania spp. in domestic donkeys from Portugal

description: Abstract Toxoplasma gondii and Leishmania infantum are zoonotic protozoal parasites. Serum samples were obtained from 186 donkeys (Equus africanus asinus) from Portugal and assessed for antibodies to T. gondii by the modified agglutination test (MAT). For titration of antibodies to Leishmania spp. the direct agglutination test was used (DAT). Eleven donkeys were seropositive for T. gondii with titres of 20 (n = 7), 80 (n = 2), 640 (n = 1) and ≥ 2560 (n = 1). One donkey was seropositive for Leishmania spp. (titre of 800). Donkeys in Portugal are exposed to and can be infected with T. gondii and Leishmania spp.
DOI: 10.6084/m9.figshare.7899413
title: Masculinities of prostate cancer survivors: a qualitative metasynthesis

description: ABSTRACT Objective: To identify the production of knowledge in the health literature about masculinities in the context of prostate cancer survivors and to analyze the implications of this relationship for the maintenance of health care. Method: Metasynthesis of 21 qualitative studies, performed in the LILACS, MEDLINE and CINAHL databases, with the scientific descriptors of DeCS and MeSH terms masculinity, prostate neoplasms. Results: Illness due to prostate cancer imposes numerous changes in male relationships, especially the non-dominance of the body and vulnerability to treatments and their consequences. The cultural values surrounding the disease and the hegemonic behaviors have implications for the health care of men. Conclusion: It has been shown that this relationship makes it difficult to communicate about the disease, marital relationships and family support, mainly influencing neglect of health. The knowledge produced is useful to promote the engagement of men in strengthening care.
DOI: 10.6084/m9.figshare.7899416
title: Association between Toll-like receptor 4 Asp299Gly polymorphism and coronary heart disease susceptibility

description: Published data on the association between Toll-like receptor 4 (TLR4) Asp299Gly polymorphism and coronary heart disease (CHD) susceptibility are inconclusive. To derive a more precise estimation of the relationship, a meta-analysis was performed. English-language studies were identified by searching PubMed and Embase databases (up to November 2016). All epidemiological studies were regarding Caucasians because no TLR4 Asp/Gly and Gly/Gly genotypes have been detected in Asians. A total of 20 case-control studies involving 14,416 cases and 10,764 controls were included in the meta-analysis. Overall, no significant associations were found between TLR4 Asp299Gly polymorphism and CHD susceptibility in the dominant model (OR=0.89; 95%CI=0.74 to 1.06; P=0.20) pooled in the meta-analysis. In the subgroup analysis by CHD, non-significant associations were found in cases compared to controls. When stratified by control source, no significantly decreased risk was found in the additive model or dominant model. The present meta-analysis suggests that the TLR4 Asp299Gly polymorphism was not associated with decreased CHD risk in Caucasians.
DOI: 10.6084/m9.figshare.7899419.v1
title: Consumer behavior: conditioners on the purchase decision of fluid milk

description: ABSTRACT: Considering economic, contingent and cultural conditions that interfere with consumer demand, the objective of this research was to evaluate the degree of importance of these variables in the decision of the Brazilian consumer to buy fluid milk. A total 1,015 milk consumers were sampled through non-probabilistic tools such as researchers’ contact network, snowballing, and self-generated samples, in a virtual questionnaire. Non-parametric tests and univariate statistical analyzes were applied, including the chi-square test. The consumer profile interferes with the selection criteria in the purchase of fluid milk as follows: (a) women consider “price”, “product origin”, “friend recommendation”, “product appearance”, “sales offers”, and “brand” as the most important conditioners; (b) young people, aged between 18 and 25, consider “product origin” a less important attribute; (c) consumers over 45 years of age value “price” the less; (d) consumers with incomes of up to one minimum wage value “sales offers” the most. This research theoretically confirmed the hypothesis that prior information regarding milk production, especially brands, lead the decision to buy fluid milk, especially in women case. Product price and availability are complementary constraints.
DOI: 10.6084/m9.figshare.7899422.v1
title: BIOSOLIDS AS SUBSTRATE FOR THE PRODUCTION OF CEIBA SPECIOSA SEEDLINGS

description: ABSTRACT Biosolids is a problematic residual issue in Brazil and other developing countries, where it is common to discard this material in landfills and/or open dumps. However, biosolids can be recycled in agricultural and forestry activities, considering they have high contents of organic matter and nutrients. Therefore, their application in substrates to produce forest seedlings can be beneficial. The scope of this study is to evaluate substrates with different proportions of biosolids and coconut fiber in the growth and quality of seedlings of Ceiba speciosa (A. St.-Hil.) Ravenna, a native species from South America that is largely used for landscaping and forest restoration. There were studied substrates with proportions varying between 25 to 100% of biosolids and 75 to 0% of coconut fiber to produce seedlings in containers (plastic tubes with 280 cm³). At 120 days after sowing, it was measured the growth, biomass and quality of the seedlings. In general aspects, the higher the proportion of biosolids in the substrate, the higher were the growth, biomass and quality. The biosolids favored the growth in shoot height and biomass more than in diameter and root biomass. Considering the positive results and the possibility of recycling biosolids, it is recommended the use of substrates containing from 50 to 100% of biosolids to produce Ceiba speciosa seedlings in 280 cm³ plastic tubes.