cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.8313542
title: Screening for Atrial Fibrillation using a Smartphone-Based Electrocardiogram

description: <b>Background</b>: In Korea, stroke is the third most common cause of death, and 10–20% of ischemic strokes, which account for three-quarters of all strokes, are caused by atrial fibrillation (AF). Ischemic stroke can be prevented by treating AF with oral anticoagulation treatment. Therefore, the early detection and treatment of AF needs to be evaluated. We conducted AF screening in Koreans and evaluated the feasibility and acceptability of the screening program.<b>Methods</b>: This survey examined 2,422 participants in a community dementia screening program aged 60 years or older in the preliminary feasibility study, and 5,366 participants at 9 Senior Welfare Centers aged 60 years or older in the expanded feasibility study. AF screening was conducted using an automated single-lead electrocardiogram (SL-ECG) (Kardia Mobile, AliveCor, Mountain View, CA, USA). AF was confirmed with a 12-lead electrocardiogram in subjects classified as AF on the SL-ECG.<b>Results</b>: In the preliminary feasibility study, of the 2,422 subjects, 124 had AF on SL-ECG. The prevalence of AF was 3.0% (95% confidence interval [CI]: 2.4–3.8). The positive predictive value (PPV) of SL-ECG was 58.9% (95% CI: 50.1–67.1). Of the subjects diagnosed with AF, 65.8% (95% CI: 54.3–75.6) were newly diagnosed. In the expanded feasibility study, of the 5,366 subjects, 289 had AF on SL-ECG. The prevalence was 2.6% (95% CI: 2.2–3.1) and PPV of SL-ECG was 48.8% (95% CI: 43.1–54.5).<b>Conclusions</b>: AF screening using SL-ECG is feasible and acceptable for Korean population. The early detection and treatment of AF is necessary because AF is underdiagnosed and undertreated.
DOI: 10.6084/m9.figshare.8313554.v1
title: Geographic, hydrological, and climatic significance of rock glaciers in the Great Basin, USA

description: We present the first comprehensive inventory and analysis of rock glaciers in the hydrographic Great Basin (GB), United States, documenting 842 features (mean 9.9 ha; range 0.1–201 ha) across thirty-two mountain ranges. These encompassed 8° latitude (from 36.5°N to 44.3°N) and 11° longitude (from −110.7°W to −121.4°W), and composed 83.1 km<sup>2</sup>, or 1.1 percent, of the cumulative area above the lowest rock glacier elevation. Forty-five percent of the features were mapped as intact (containing ice) and occurred across sixteen mountain ranges. Rock glaciers conservatively contained cumulative water volume of 0.8924 km<sup>3</sup>. We also mapped 237 persistent ice fields from thirteen GB ranges. Ice-field water equivalent was 0.0653 km<sup>3</sup>; rock glaciers contributed 93 percent of the total water volume (rock glacier:icefield ratio, 14:1). Rock glaciers occurred on northerly aspects at high elevations (mean, 3,196 m) and had a mean annual air temperature of 1.7°C (range, 1.3–3.3°C). Contributions of water from rock-glacier springs and groundwater have not been included in GB hydrologic assessments, nor have rock glaciers been evaluated for their roles in supporting cold-adapted aquatic fauna and promoting vegetation communities and habitat for alpine terrestrial species. Rock glaciers provide hydrologic and ecologic refugia previously unrecognized in the GB with respect to warming future climates.
DOI: 10.6084/m9.figshare.8313542.v1
title: Screening for Atrial Fibrillation using a Smartphone-Based Electrocardiogram

description: <b>Background</b>: In Korea, stroke is the third most common cause of death, and 10–20% of ischemic strokes, which account for three-quarters of all strokes, are caused by atrial fibrillation (AF). Ischemic stroke can be prevented by treating AF with oral anticoagulation treatment. Therefore, the early detection and treatment of AF needs to be evaluated. We conducted AF screening in Koreans and evaluated the feasibility and acceptability of the screening program.<b>Methods</b>: This survey examined 2,422 participants in a community dementia screening program aged 60 years or older in the preliminary feasibility study, and 5,366 participants at 9 Senior Welfare Centers aged 60 years or older in the expanded feasibility study. AF screening was conducted using an automated single-lead electrocardiogram (SL-ECG) (Kardia Mobile, AliveCor, Mountain View, CA, USA). AF was confirmed with a 12-lead electrocardiogram in subjects classified as AF on the SL-ECG.<b>Results</b>: In the preliminary feasibility study, of the 2,422 subjects, 124 had AF on SL-ECG. The prevalence of AF was 3.0% (95% confidence interval [CI]: 2.4–3.8). The positive predictive value (PPV) of SL-ECG was 58.9% (95% CI: 50.1–67.1). Of the subjects diagnosed with AF, 65.8% (95% CI: 54.3–75.6) were newly diagnosed. In the expanded feasibility study, of the 5,366 subjects, 289 had AF on SL-ECG. The prevalence was 2.6% (95% CI: 2.2–3.1) and PPV of SL-ECG was 48.8% (95% CI: 43.1–54.5).<b>Conclusions</b>: AF screening using SL-ECG is feasible and acceptable for Korean population. The early detection and treatment of AF is necessary because AF is underdiagnosed and undertreated.
DOI: 10.6084/m9.figshare.8313506
title: Synthesis, characterization, structural elucidation and biological screening of some <i>bis</i>(diisobutyldithiophosphato)antimony(III) complexes

description: Seven complexes of type [(C<sub>4</sub>H<sub>9</sub><i><sup>i</sup></i>-O)<sub>2</sub>PS<sub>2</sub>]<sub>2</sub>SbR have been synthesized by the reaction of chloro<i>bis</i>(diisobutyldithiophosphato)antimony(III) with mixed thio and/or oxo donor ligands in 1:1 M stoichiometry, where R = SC<sub>6</sub>H<sub>5</sub>, OOCC<sub>6</sub>H<sub>5</sub>, SCH<sub>2</sub>COOH, SOCCH<sub>3</sub>, OOCCH<sub>3</sub>, SC<sub>6</sub>H<sub>4</sub>COOH and OOC(OH)C<sub>6</sub>H<sub>4</sub>. These newly synthesized derivatives have been characterized by different physicochemical (elemental analysis (C, H, S, Sb), melting point, molecular weight determination), spectral (UV, IR, NMR (<sup>1</sup>H, <sup>13</sup>C and <sup>31</sup>P)) studies, as well as ESI mass, thermal, powder XRD and biological studies. In the final step of weight loss in thermogravimetric analysis, occurring in the range of 245–505 °C, the degradation of the C<sub>6</sub>H<sub>3</sub>CO moieties takes place and antimony sulfide (1/2 Sb<sub>2</sub>S<sub>3</sub>) is obtained as remaining material, which is useful in various aspects. Bonded to antimony the diisobutyldithiophosphato substituent behaves as an anisobidentate ligand, which is confirmed through spectral analysis. Powder XRD studies indicate that these compounds crystallize in a monoclinic crystal system with an unit cell volume of ∼7074–7162 Å<sup>3</sup> forming nano ranged (9.69–15.69 nm) crystallites. From the antimicrobial screening tests, <i>bis</i>(diisobutyldithiophosphato)antimony(III) thioglycolate (compound <b>3</b>) has shown a maximum zone of inhibition (19 mm) against <i>E. coli</i> at 200 μg mL<sup>−1</sup> concentration.
DOI: 10.6084/m9.figshare.8313506.v2
title: Synthesis, characterization, structural elucidation and biological screening of some <i>bis</i>(diisobutyldithiophosphato)antimony(III) complexes

description: Seven complexes of type [(C<sub>4</sub>H<sub>9</sub><i><sup>i</sup></i>-O)<sub>2</sub>PS<sub>2</sub>]<sub>2</sub>SbR have been synthesized by the reaction of chloro<i>bis</i>(diisobutyldithiophosphato)antimony(III) with mixed thio and/or oxo donor ligands in 1:1 M stoichiometry, where R = SC<sub>6</sub>H<sub>5</sub>, OOCC<sub>6</sub>H<sub>5</sub>, SCH<sub>2</sub>COOH, SOCCH<sub>3</sub>, OOCCH<sub>3</sub>, SC<sub>6</sub>H<sub>4</sub>COOH and OOC(OH)C<sub>6</sub>H<sub>4</sub>. These newly synthesized derivatives have been characterized by different physicochemical (elemental analysis (C, H, S, Sb), melting point, molecular weight determination), spectral (UV, IR, NMR (<sup>1</sup>H, <sup>13</sup>C and <sup>31</sup>P)) studies, as well as ESI mass, thermal, powder XRD and biological studies. In the final step of weight loss in thermogravimetric analysis, occurring in the range of 245–505 °C, the degradation of the C<sub>6</sub>H<sub>3</sub>CO moieties takes place and antimony sulfide (1/2 Sb<sub>2</sub>S<sub>3</sub>) is obtained as remaining material, which is useful in various aspects. Bonded to antimony the diisobutyldithiophosphato substituent behaves as an anisobidentate ligand, which is confirmed through spectral analysis. Powder XRD studies indicate that these compounds crystallize in a monoclinic crystal system with an unit cell volume of ∼7074–7162 Å<sup>3</sup> forming nano ranged (9.69–15.69 nm) crystallites. From the antimicrobial screening tests, <i>bis</i>(diisobutyldithiophosphato)antimony(III) thioglycolate (compound <b>3</b>) has shown a maximum zone of inhibition (19 mm) against <i>E. coli</i> at 200 μg mL<sup>−1</sup> concentration.
DOI: 10.6084/m9.figshare.8313506.v1
title: Synthesis, characterization, structural elucidation and biological screening of some <i>bis</i>(diisobutyldithiophosphato)antimony(III) complexes

description: Seven complexes of type [(C<sub>4</sub>H<sub>9</sub><i><sup>i</sup></i>-O)<sub>2</sub>PS<sub>2</sub>]<sub>2</sub>SbR have been synthesized by the reaction of chloro<i>bis</i>(diisobutyldithiophosphato)antimony(III) with mixed thio and/or oxo donor ligands in 1:1 M stoichiometry, where R = SC<sub>6</sub>H<sub>5</sub>, OOCC<sub>6</sub>H<sub>5</sub>, SCH<sub>2</sub>COOH, SOCCH<sub>3</sub>, OOCCH<sub>3</sub>, SC<sub>6</sub>H<sub>4</sub>COOH and OOC(OH)C<sub>6</sub>H<sub>4</sub>. These newly synthesized derivatives have been characterized by different physicochemical (elemental analysis (C, H, S, Sb), melting point, molecular weight determination), spectral (UV, IR, NMR (<sup>1</sup>H, <sup>13</sup>C and <sup>31</sup>P)) studies, as well as ESI mass, thermal, powder XRD and biological studies. In the final step of weight loss in thermogravimetric analysis, occurring in the range of 245–505 °C, the degradation of the C<sub>6</sub>H<sub>3</sub>CO moieties takes place and antimony sulfide (1/2 Sb<sub>2</sub>S<sub>3</sub>) is obtained as remaining material, which is useful in various aspects. Bonded to antimony the diisobutyldithiophosphato substituent behaves as an anisobidentate ligand, which is confirmed through spectral analysis. Powder XRD studies indicate that these compounds crystallize in a monoclinic crystal system with an unit cell volume of ∼7074–7162 Å<sup>3</sup> forming nano ranged (9.69–15.69 nm) crystallites. From the antimicrobial screening tests, <i>bis</i>(diisobutyldithiophosphato)antimony(III) thioglycolate (compound <b>3</b>) has shown a maximum zone of inhibition (19 mm) against <i>E. coli</i> at 200 μg mL<sup>−1</sup> concentration.
DOI: 10.6084/m9.figshare.8313371
title: Supplemental material for "Widespread cell-specific prolactin receptor expression in multiple murine organs"

description: The prolactin receptor (Prlr) mediates not only the multiple effects of prolactin, but also those of the placental lactogens and, in humans, some actions of growth hormone. While Prlr expression has been reported to be widespread in the body, specific cellular expression patterns within tissues are undefined for many organs. One persisting problem in investigating Prlr function is, that the protein is difficult to detect using conventional methods. To allow investigation of Prlr expression with a single cell resolution, we have recently developed a knock-in mouse strain in which Cre recombinase is expressed together with the long isoform of the Prlr using an internal ribosome entry site (IRES). When crossed to a Cre-dependent reporter mouse strain, Cre-mediated recombination will genetically label cells that acutely express the Prlr as well as cells that have transiently expressed the Prlr during development. We report here the anatomical distribution of cells which express the fluorescent reporter GFP in a total of 38 organs prepared from young adult male and female prolactin receptor reporter mice. Our results establish a novel resource for dissecting the functional role of Prlr in multiple murine tissues.
DOI: 10.6084/m9.figshare.8313386.v2
title: FigShare Data.xlsx

description: We provided the intra-tendinous morphology data from ultrasound imaging. The runners' demographics, running history, body measures, and clinical measures (endurance and flexibility) was also provided.
DOI: 10.6084/m9.figshare.8313308
title: Pre-operative plasma cell-free circulating tumor DNA and serum protein tumor markers as predictors of lung adenocarcinoma recurrence

description: <b>Background:</b> Lung cancer patients have a risk of recurrence even after curatively intended surgery. Cell-free circulating tumor DNA (ctDNA) and circulating tumor marker measurements are easily accessible through peripheral blood and could potentially identify patients with worse prognosis. The aim of this study was to examine ctDNA in pre-operative plasma and the role of tumor markers in pre-operative serum for their predictive potential on risk of tumor recurrence. <b>Methods:</b> Mutation analysis by 26-gene targeted sequencing was performed on 157 lung adenocarcinomas (ACs) from patients surgically treated at the Lund University Hospital 2005–2014. Of these, 58 tumors from patients in stages I–IIIA (34 stage I, 14 stage II and 10 stage III) with mutation(s) in <i>EGFR</i>, <i>BRAF</i> or <i>KRAS</i> were included. ctDNA from corresponding plasma (median 1.5 ml, range 1–1.6) was analyzed for one tumor-specific mutation in either of these three oncogenes using ultrasensitive IBSAFE droplet digital PCR (ddPCR). The tumor markers cancer antigen 125 (CA 125) and carbohydrate antigen 19-9 (CA 19-9) were analyzed in corresponding serum with electrochemiluminiscence immunoassay. <b>Results:</b> 6/7 patients with ctDNA and 19/51 without detected ctDNA were diagnosed with recurrence (log-rank test <i>p</i> = .001). 8/10 patients with positive serum tumor markers and 17/47 without tumor markers were diagnosed with recurrence (log-rank test, <i>p</i> = .0002). Fifteen patients had positive ctDNA and/or tumor markers, 12 of these had recurrence (log-rank test, <i>p</i> <b>Conclusion:</b> A combination of tumor markers and ctDNA single mutation detection in low-volume pre-operative blood samples is a promising prognostic test. Prediction of recurrent disease in surgically treated early stage lung cancer can likely be further improved by using larger volumes of blood.
DOI: 10.6084/m9.figshare.8313308.v1
title: Pre-operative plasma cell-free circulating tumor DNA and serum protein tumor markers as predictors of lung adenocarcinoma recurrence

description: <b>Background:</b> Lung cancer patients have a risk of recurrence even after curatively intended surgery. Cell-free circulating tumor DNA (ctDNA) and circulating tumor marker measurements are easily accessible through peripheral blood and could potentially identify patients with worse prognosis. The aim of this study was to examine ctDNA in pre-operative plasma and the role of tumor markers in pre-operative serum for their predictive potential on risk of tumor recurrence. <b>Methods:</b> Mutation analysis by 26-gene targeted sequencing was performed on 157 lung adenocarcinomas (ACs) from patients surgically treated at the Lund University Hospital 2005–2014. Of these, 58 tumors from patients in stages I–IIIA (34 stage I, 14 stage II and 10 stage III) with mutation(s) in <i>EGFR</i>, <i>BRAF</i> or <i>KRAS</i> were included. ctDNA from corresponding plasma (median 1.5 ml, range 1–1.6) was analyzed for one tumor-specific mutation in either of these three oncogenes using ultrasensitive IBSAFE droplet digital PCR (ddPCR). The tumor markers cancer antigen 125 (CA 125) and carbohydrate antigen 19-9 (CA 19-9) were analyzed in corresponding serum with electrochemiluminiscence immunoassay. <b>Results:</b> 6/7 patients with ctDNA and 19/51 without detected ctDNA were diagnosed with recurrence (log-rank test <i>p</i> = .001). 8/10 patients with positive serum tumor markers and 17/47 without tumor markers were diagnosed with recurrence (log-rank test, <i>p</i> = .0002). Fifteen patients had positive ctDNA and/or tumor markers, 12 of these had recurrence (log-rank test, <i>p</i> <b>Conclusion:</b> A combination of tumor markers and ctDNA single mutation detection in low-volume pre-operative blood samples is a promising prognostic test. Prediction of recurrent disease in surgically treated early stage lung cancer can likely be further improved by using larger volumes of blood.
DOI: 10.6084/m9.figshare.8313257
title: Value-sensitive Sustainable Consumption (ASSET)

description: ASSET Data.
DOI: 10.15131/shef.data.8313254
title: Data for the paper: "The longitudinal effects of ovariectomy on the morphometric, densitometric and mechanical properties in the murine tibia: a comparison between two mouse strains"

description: Link to the data used in:<br>Roberts, Giorgi, Oliviero, Wang, Boudiffa,Dall’Ara<br>The longitudinal effects of ovariectomy on the morphometric, densitometric and mechanical properties in the murine tibia: a comparison between two mouse strains<br>Bone 2019.<br>The images and data are too large to be uploaded in ORDA, so please contact the senior author at: e.dallara@sheffield.ac.uk or the Project Management Office at: pmo@insigneo.org if you are interested in working on the files.<br>The whole dataset can be assessed at: <br>https://web-unidrive.sheffield.ac.uk/shared/multisim2/WP7/Mario_Giorgi/OVX_Study/<br>In this repository we have uploaded only the result file obtained from assessment of the microCT images.<br><br>
DOI: 10.6084/m9.figshare.8313233
title: Transition Probs File

description: Text file for input into TDCM reliability R script. Simulated example.
DOI: 10.6084/m9.figshare.8313257.v2
title: Personalized Sustainability Ratings

description: ASSET Data.
DOI: 10.6084/m9.figshare.8313233.v1
title: Transition Probs File

description: Text file for input into TDCM reliability R script. Simulated example.
DOI: 10.6084/m9.figshare.8313257.v3
title: Value-sensitive Sustainable Consumption (ASSET)

description: ASSET Data.
DOI: 10.6084/m9.figshare.8313188
title: Example 1 Data File

description: TDCM Example Data File; Simulated, N = 2000, 24 items, two time points
DOI: 10.6084/m9.figshare.8313185
title: mat_public_data_promiscuous_DBS4_sort.csv

description: Datastet called DBS4 from the study "High Impact: The Role of Promiscuous Binding Site in Polypharmacology". The 7.267 pockets are named according to the ligand (HET code from the Protein Data Bank), the protein (PDB code), the letter of the protein chain, and the numero of the ligand by chain (differs from 1 if there is more than 1 ligand in the chain), separated by underscores. The pocket cluster and ligand cluster columns are the name of each clusters, respectively 481 pocket clusters and 1.969 ligand clusters. The name of the 3.488 ligands correspond to the HET codes from the Protein Data Bank. The promiscuity of Druggable Binding Site (DBS), corresponding to pocket clusters) is leveled in 3 categories : Selective (S), Moderately Promiscuous (MP) and Highly Promiscuous (HP) meaning that DBS interact with respectively only one, two or three, or more than three ligand-clusters. The promiscuity of Ligand clusters is leveled in 2 categories : Selective (S), they bind to only one DBS and Promiscuous (Prom), they bind to several DBS.
DOI: 10.6084/m9.figshare.8313188.v1
title: Example 1 Data File

description: TDCM Example Data File; Simulated, N = 2000, 24 items, two time points
DOI: 10.6084/m9.figshare.8313176
title: Supplemental figures for "Widespread cell-specific prolactin receptor expression in mutiple murine organs"

description: The prolactin receptor (Prlr) mediates not only the multiple effects of prolactin, but also those of the placental lactogens and, in humans, some actions of growth hormone. While Prlr expression has been reported to be widespread in the body, specific cellular expression patterns within tissues are undefined for many organs. One persisting problem in investigating Prlr function is, that the protein is difficult to detect using conventional methods. To allow investigation of Prlr expression with a single cell resolution, we have recently developed a knock-in mouse strain in which Cre recombinase is expressed together with the long isoform of the Prlr using an internal ribosome entry site (IRES). When crossed to a Cre-dependent reporter mouse strain, Cre-mediated recombination will genetically label cells that acutely express the Prlr as well as cells that have transiently expressed the Prlr during development. We report here the anatomical distribution of cells which express the fluorescent reporter GFP in a total of 38 organs prepared from young adult male and female prolactin receptor reporter mice. Our results establish a novel resource for dissecting the functional role of Prlr in multiple murine tissues.<br>
DOI: 10.6084/m9.figshare.8313185.v1
title: mat_public_data_promiscuous_DBS4_sort.csv

description: Datastet called DBS4 from the study "High Impact: The Role of Promiscuous Binding Site in Polypharmacology". The 7.267 pockets are named according to the ligand (HET code from the Protein Data Bank), the protein (PDB code), the letter of the protein chain, and the numero of the ligand by chain (differs from 1 if there is more than 1 ligand in the chain), separated by underscores. The pocket cluster and ligand cluster columns are the name of each clusters, respectively 481 pocket clusters and 1.969 ligand clusters. The name of the 3.488 ligands correspond to the HET codes from the Protein Data Bank. The promiscuity of Druggable Binding Site (DBS), corresponding to pocket clusters) is leveled in 3 categories : Selective (S), Moderately Promiscuous (MP) and Highly Promiscuous (HP) meaning that DBS interact with respectively only one, two or three, or more than three ligand-clusters. The promiscuity of Ligand clusters is leveled in 2 categories : Selective (S), they bind to only one DBS and Promiscuous (Prom), they bind to several DBS.
DOI: 10.6084/m9.figshare.8313170
title: A multiscale analysis of land use dynamics in the buffer zone of Rio Doce State Park, Minas Gerais, Brazil

description: This article uses a multiscale approach for assessing landscape changes in one of the world’s biodiversity hotspots in Brazil, the Rio Doce State Park (PERD). In this article, we assess land use changes over a 30 year period. Our results show that, while inside the park landscape changes were minimal, in the park buffer zone human induced changes are steadily rising due to an increase in eucalyptus plantations and urban sprawl that grew by 4% and 1.9%, respectively. Agricultural land has been reduced by 6.35%, but there are trends that a form of welcome forest transition has been occurring. We report an increase in native forests from 40,588 ha in 1985 to 45,690 ha in 2015. The analysis of human impacts in the study area delivers very different results when varying the pixel size from 25 ha to 900 m<sup>2</sup>. The former shows a very high level of human influence while the latter reveals small but vital patches of native forest offering hopeful opportunities for sustainable natural resource management in this critical biome. Our work stresses the importance of better targeted policy making and sympathetic land use management of buffer zones of protected areas. Currently, such zones suffer from many development pressures and often experience contradictory policy frameworks which encourage a clash between biodiversity conservation and intensive agro husbandry production. <b>Highlights:</b> • We characterize land use transitions in a hotspot of biodiversity in Brazil. • Analysis at finer resolution show that there is still hope for forest recovery. • For instilling sustainable forest transitions there is the need for fresh governance.