cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.25144232
title: Emotional Design for Pro-Environmental Life-Data.xlsx

description: DATA for 'Emotional Design for Pro-Environmental Life: Visual Appeal and User Interactivity Influence Sustainable Consumption Intention with the Moderating Effect of Positive Emotion in the Pro-Environmental Mobile Application'
DOI: 10.6084/m9.figshare.25144238
title: Self-reliance in Primary Healthcare Using Traditional Medicine

description: The data contains In-depth interviews and focus group discussions of HD Kote data.
DOI: 10.6084/m9.figshare.25144238.v1
title: Self-reliance in Primary Healthcare Using Traditional Medicine

description: The data contains In-depth interviews and focus group discussions of HD Kote data.
DOI: 10.5255/ukda-sn-856885
title: Commuter Dilemma Game: Interviews Conducted whilst Playing a Serious Game, 2022-2023

description: The transport sector is responsible for around 20% of global CO2 emissions, and road transport alone contributes to three-quarters of that share. Since the European Union will implement a separate Emissions Trading System in 2027, which will cover road transport, buildings and additional sectors (mainly small industry), the study considered the idea for the UK. The research specifically explored differences in perceptions of fuel price increases as a result of an increase in fuel duties or as a result of the introduction of a parallel Emissions Trading System for road transport. A Serious Game was used to elicit perceptions. In the game, called the Commuter Dilemma Game, car drivers were presented with situations where they needed to make decisions in response to an increase in the pump price of fuel. The sample was a convenient sample, and therefore not representative. 

The players had to make decisions during the game were the essential, and these were aimed at triggering a discussion about the perception of an increase in the pump price of fuel resulting from different policies. Six decisions could be made: 

a) To choose which transport mode to use (car, bus, bicycle, walk), each with an associated time and fuel cost, 
b) To replace their car with a more efficient car,
c) To not visit some of the facilities (such as health, education, shopping or leisure facilities) to reduce expenses,
d) To move house,
e) To complain about the policies triggering an increase in pump prices (with the complaint being some sort of formal complaint to the government, or simply moaning), and
f) To join a demonstration against the pump price increase.
DOI: 10.6084/m9.figshare.24119837
title: Bidirectional association between hypothyroidism and myasthenia gravis: a Mendelian randomized study

description: Although observational studies have suggested a link between hypothyroidism and myasthenia gravis (MG), a causal relationship has not been established. We aimed to investigate the causal association using a two-sample Mendelian randomization (MR) study. Using summary statistics from genome-wide association studies involving 494,577 and 38,243 individuals, single-nucleotide polymorphisms exhibiting no linkage disequilibrium (r2 ≤ 0.001) and displaying significant differences (<i>p</i> ≤ 5 × 10<sup>−8</sup>) were selected for hypothyroidism and MG. To assess the potential causality relationship between hypothyroidism and MG, MR analysis was conducted using inverse variance weighted (IVW), weighted median method, and MR-Egger. The MR-Egger regression, heterogeneity test, pleiotropy test, and leave-one-out sensitivity test were employed to examine sensitivity analyses. In addition, validation datasets were used to validate the relevant results. Genetic liability to hypothyroidism was positively associated with MG (IVW, OR: 1.36, 95% CI: 1.17–1.58, <i>p</i> = 7.53 × 10–05; weighted median, OR: 1.19, 95% CI: 0.70–2.02, <i>p</i> = 0.522; MR-Egger, OR: 1.19, 95% CI: 0.98–1.45, <i>p</i> = 0.080). Among the three MR methods, the correlation between hypothyroidism and MG genetic prediction was consistent. The independent validation set (IVW, OR: 466.47, 95% CI: 4.70 -46,285.95, <i>p</i> = 0.01) further supported this. Additionally, bidirectional studies showed that using IVW, there was no reverse causality (OR: 1.104, 95%CI: 0.96–1.27, <i>p</i> = 0.170). This MR study showed that hypothyroidism can increase the risk of MG. Further investigation into the underlying mechanisms of this potential causality is warranted to offer novel therapeutic options for MG in the future.
DOI: 10.6084/m9.figshare.24119837.v1
title: Bidirectional association between hypothyroidism and myasthenia gravis: a Mendelian randomized study

description: Although observational studies have suggested a link between hypothyroidism and myasthenia gravis (MG), a causal relationship has not been established. We aimed to investigate the causal association using a two-sample Mendelian randomization (MR) study. Using summary statistics from genome-wide association studies involving 494,577 and 38,243 individuals, single-nucleotide polymorphisms exhibiting no linkage disequilibrium (r2 ≤ 0.001) and displaying significant differences (<i>p</i> ≤ 5 × 10<sup>−8</sup>) were selected for hypothyroidism and MG. To assess the potential causality relationship between hypothyroidism and MG, MR analysis was conducted using inverse variance weighted (IVW), weighted median method, and MR-Egger. The MR-Egger regression, heterogeneity test, pleiotropy test, and leave-one-out sensitivity test were employed to examine sensitivity analyses. In addition, validation datasets were used to validate the relevant results. Genetic liability to hypothyroidism was positively associated with MG (IVW, OR: 1.36, 95% CI: 1.17–1.58, <i>p</i> = 7.53 × 10–05; weighted median, OR: 1.19, 95% CI: 0.70–2.02, <i>p</i> = 0.522; MR-Egger, OR: 1.19, 95% CI: 0.98–1.45, <i>p</i> = 0.080). Among the three MR methods, the correlation between hypothyroidism and MG genetic prediction was consistent. The independent validation set (IVW, OR: 466.47, 95% CI: 4.70 -46,285.95, <i>p</i> = 0.01) further supported this. Additionally, bidirectional studies showed that using IVW, there was no reverse causality (OR: 1.104, 95%CI: 0.96–1.27, <i>p</i> = 0.170). This MR study showed that hypothyroidism can increase the risk of MG. Further investigation into the underlying mechanisms of this potential causality is warranted to offer novel therapeutic options for MG in the future.
DOI: 10.5676/eum_saf_cm/uth/v002
title: CM SAF Passive Microwave Upper Tropospheric Humidity (UTH) Data Record - Edition 2

description: The second edition of the CM SAF Upper Tropospheric Humidity (UTH) is a satellite-based
 climate data record. It is a near-global 1°x1° latitude-longitude dataset that is produced
 with both hourly and daily time steps. The dataset is based on data from twelve passive
 microwave (MW) sounders operating at 183 GHz in polar orbit that are combined into a single
 time series covering the period 6 July 1994 to 31 December 2018. The UTH provided typically
 represents a broad atmospheric layer between 500 and 200 hPa. However, the exact height of
 this layer depends on the atmospheric conditions at the time of the observation. An optional
 fixed layer approximation adjustment is supplied that users can apply to provide an estimated
 mean relative humidity (RH) between ±60° latitude for a fixed layer between 500 and 200 hPa
 (mean_RH). However, users are advised to take care using this correction, especially outside
 of the tropics where the mean_RH is of lower quality. Users are also advised to take care
 using UTH observations above ±60° latitude as the retrieval is sometimes less reliable at high
 latitudes. Further information describing the dataset in detail can be found in the available
 product documentation.
DOI: 10.4121/13633658.v1
title: Dataset corresponding to publication: "Bubbly drag reduction using a hydrophobic inner cylinder in Taylor–Couette turbulence"

description: This dataset contains measurement data from drag reduction experiments over hydrophilic and hydrophobic walls in turbulent single-phase and two-phase flows. A Taylor–Couette apparatus was used for the experiments, of which the inner cylinder was made hydrophobic by applying a coating. <br>See readme.txt file for more information regarding the dataset.<br>
DOI: 10.6084/m9.figshare.14157853.v1
title: Additional file 16 of FBW7 suppresses ovarian cancer development by targeting the N6-methyladenosine binding protein YTHDF2

description: Additional file 16: Table S3. The list of differentially identified proteins by the co-IP-mass spectrometry analysis.
DOI: 10.6084/m9.figshare.6818012.v2
title: Conflicts of CpG density and DNA methylation are proximally and distally involved in gene regulation in human and mouse tissues

description: The relationship between CpG content and DNA methylation has attracted considerable interest in recent years. Direct or indirect methods have been developed to investigate their regulatory functions based on various hypotheses, large cohort studies, and meta-analyses. However, all of these analyses were performed at units of CpG blocks and, thus, the influence of finer genome structure has been neglected. Herein, we present a novel algorithm of base-pair resolution to systematically investigate the relationship between CpG contents and DNA methylation. By introducing the concept of ‘complementary index’ we examined the methylomes of 34 adult and 7 embryonic tissues and successfully fitted the relationship of DNA methylation and CpG density into a nonlinear mathematical model. A further algorithm was developed to locate the regions where CpG density does not match expectations from the model, termed ‘conflict of gap’ (COG) regions. Interestingly, COGs are highly concordant in human and mouse and their distributions display a tissue-specific pattern. Based on COG methylation patterns we correctly classified tissues according to their function or origin. We demonstrate that COGs based on our method can reveal more and deeper information than traditional differential methylation region (DMR) approaches. We also found that when COGs are located near to transcription start site (TSS), these regions can determine which promoters will be utilized for initiating gene transcription. Furthermore, COGs located far from the TSS perform as enhancers in terms of histone modification, sequence conservation, transcription factor binding, and DNase I-hypersensitivity.
DOI: 10.6084/m9.figshare.6818012.v1
title: Conflicts of CpG density and DNA methylation are proximally and distally involved in gene regulation in human and mouse tissues

description: The relationship between CpG content and DNA methylation has attracted considerable interest in recent years. Direct or indirect methods have been developed to investigate their regulatory functions based on various hypotheses, large cohort studies, and meta-analyses. However, all of these analyses were performed at units of CpG blocks and, thus, the influence of finer genome structure has been neglected. Herein, we present a novel algorithm of base-pair resolution to systematically investigate the relationship between CpG contents and DNA methylation. By introducing the concept of “complementary index” we examined the methylomes of 34 adult and 7 embryonic tissues and successfully fitted the relationship of DNA methylation and CpG density into a nonlinear mathematical model. A further algorithm was developed to locate the regions where CpG density does not match expectations from the model, termed ‘conflict of gap’ (COG) regions. Interestingly, COGs are highly concordant in human and mouse and their distributions display a tissue-specific pattern. Based on COG methylation patterns we correctly classified tissues according to their function or origin. We demonstrate that COGs based on our method can reveal more and deeper information than traditional differential methylation region (DMR) approaches. We also found that when COGs are located near to transcription start site (TSS), these regions can determine which promoters will be utilized for initiating gene transcription. Furthermore, COGs located far from the TSS perform as enhancers in terms of histone modification, sequence conservation, transcription factor binding, and DNase I-hypersensitivity.
DOI: 10.6084/m9.figshare.13109442
title: The therapeutic effect of habit reversal training for Tourette syndrome: a meta-analysis of randomized control trials

description: Comprehensive behavioral intervention for tics (CBIT) and habit reversal training (HRT) are forms of cognitive behavioral therapy that can effectively reduce tic symptoms in patients with tic disorders, but their efficacies and potential moderators were needed to be clarified. In the present study, a meta-analysis was performed to identify the efficacy of HRT and CBIT for individuals with tic disorders. The standard mean difference (SMD) was calculated to assess the effect size of the efficacy of HRT. Subgroup analysis and meta-regression analysis were performed to identify the potential heterogeneity of the SMD of HRT. A total of 10 randomized controlled trials (RCTs) including 586 patients with tic disorders were identified. The pooled SMD was −0.43 (95% CI: −0.71, −0.16). The effect size of HRT was moderated by different ‘Comparison Conditions’ (it means the different behavioral therapies in the control group). Overall, the authors found a small to medium effect size for the efficacy of HRT. As the most promising behavioral therapy, they conclude that HRT is effective for the treatment of patients with tic disorders. Further high-quality RCTs are needed to determine the efficacy of HRT compared with that of medications.
DOI: 10.6084/m9.figshare.6818012
title: Conflicts of CpG density and DNA methylation are proximally and distally involved in gene regulation in human and mouse tissues

description: The relationship between CpG content and DNA methylation has attracted considerable interest in recent years. Direct or indirect methods have been developed to investigate their regulatory functions based on various hypotheses, large cohort studies, and meta-analyses. However, all of these analyses were performed at units of CpG blocks and, thus, the influence of finer genome structure has been neglected. Herein, we present a novel algorithm of base-pair resolution to systematically investigate the relationship between CpG contents and DNA methylation. By introducing the concept of ‘complementary index’ we examined the methylomes of 34 adult and 7 embryonic tissues and successfully fitted the relationship of DNA methylation and CpG density into a nonlinear mathematical model. A further algorithm was developed to locate the regions where CpG density does not match expectations from the model, termed ‘conflict of gap’ (COG) regions. Interestingly, COGs are highly concordant in human and mouse and their distributions display a tissue-specific pattern. Based on COG methylation patterns we correctly classified tissues according to their function or origin. We demonstrate that COGs based on our method can reveal more and deeper information than traditional differential methylation region (DMR) approaches. We also found that when COGs are located near to transcription start site (TSS), these regions can determine which promoters will be utilized for initiating gene transcription. Furthermore, COGs located far from the TSS perform as enhancers in terms of histone modification, sequence conservation, transcription factor binding, and DNase I-hypersensitivity.
DOI: 10.6084/m9.figshare.13109442.v1
title: The therapeutic effect of habit reversal training for Tourette syndrome: a meta-analysis of randomized control trials

description: Comprehensive behavioral intervention for tics (CBIT) and habit reversal training (HRT) are forms of cognitive behavioral therapy that can effectively reduce tic symptoms in patients with tic disorders, but their efficacies and potential moderators were needed to be clarified. In the present study, a meta-analysis was performed to identify the efficacy of HRT and CBIT for individuals with tic disorders. The standard mean difference (SMD) was calculated to assess the effect size of the efficacy of HRT. Subgroup analysis and meta-regression analysis were performed to identify the potential heterogeneity of the SMD of HRT. A total of 10 randomized controlled trials (RCTs) including 586 patients with tic disorders were identified. The pooled SMD was −0.43 (95% CI: −0.71, −0.16). The effect size of HRT was moderated by different ‘Comparison Conditions’ (it means the different behavioral therapies in the control group). Overall, the authors found a small to medium effect size for the efficacy of HRT. As the most promising behavioral therapy, they conclude that HRT is effective for the treatment of patients with tic disorders. Further high-quality RCTs are needed to determine the efficacy of HRT compared with that of medications.
DOI: 10.6084/m9.figshare.20449692
title: Adverse outcome pathways and linkages to transcriptomic effects relevant to ionizing radiation injury

description: In the past three decades, a large body of data on the effects of exposure to ionizing radiation and the ensuing changes in gene expression has been generated. These data have allowed for an understanding of molecular-level events and shown a level of consistency in response despite the vast formats and experimental procedures being used across institutions. However, clarity on how this information may inform strategies for health risk assessment needs to be explored. An approach to bridge this gap is the adverse outcome pathway (AOP) framework. AOPs represent an illustrative framework characterizing a stressor associated with a sequential set of causally linked key events (KEs) at different levels of biological organization, beginning with a molecular initiating event (MIE) and culminating in an adverse outcome (AO). Here, we demonstrate the interpretation of transcriptomic datasets in the context of the AOP framework within the field of ionizing radiation by using a lung cancer AOP (AOP 272: https://www.aopwiki.org/aops/272) as a case example. Through the mining of the literature, radiation exposure-related transcriptomic studies in line with AOP 272 related to lung cancer, DNA damage response, and repair were identified. The differentially expressed genes within relevant studies were collated and subjected to the pathway and network analysis using Reactome and GeneMANIA platforms. Identified pathways were filtered (<i>p</i> &lt; .001, ≥3 genes) and categorized based on relevance to KEs in the AOP. Gene connectivities were identified and further grouped by gene expression-informed associated events (AEs). Relevant quantitative dose-response data were used to inform the directionality in the expression of the genes in the network across AEs. Reactome analyses identified 7 high-level biological processes with multiple pathways and associated genes that mapped to potential KEs in AOP 272. The gene connectivities were further represented as a network of AEs with associated expression profiles that highlighted patterns of gene expression levels. This study demonstrates the application of transcriptomics data in AOP development and provides information on potential data gaps. Although the approach is new and anticipated to evolve, it shows promise for improving the understanding of underlying mechanisms of disease progression with a long-term vision to be predictive of adverse outcomes.
DOI: 10.6084/m9.figshare.20449692.v2
title: Adverse outcome pathways and linkages to transcriptomic effects relevant to ionizing radiation injury

description: In the past three decades, a large body of data on the effects of exposure to ionizing radiation and the ensuing changes in gene expression has been generated. These data have allowed for an understanding of molecular-level events and shown a level of consistency in response despite the vast formats and experimental procedures being used across institutions. However, clarity on how this information may inform strategies for health risk assessment needs to be explored. An approach to bridge this gap is the adverse outcome pathway (AOP) framework. AOPs represent an illustrative framework characterizing a stressor associated with a sequential set of causally linked key events (KEs) at different levels of biological organization, beginning with a molecular initiating event (MIE) and culminating in an adverse outcome (AO). Here, we demonstrate the interpretation of transcriptomic datasets in the context of the AOP framework within the field of ionizing radiation by using a lung cancer AOP (AOP 272: https://www.aopwiki.org/aops/272) as a case example. Through the mining of the literature, radiation exposure-related transcriptomic studies in line with AOP 272 related to lung cancer, DNA damage response, and repair were identified. The differentially expressed genes within relevant studies were collated and subjected to the pathway and network analysis using Reactome and GeneMANIA platforms. Identified pathways were filtered (<i>p</i> &lt; .001, ≥3 genes) and categorized based on relevance to KEs in the AOP. Gene connectivities were identified and further grouped by gene expression-informed associated events (AEs). Relevant quantitative dose-response data were used to inform the directionality in the expression of the genes in the network across AEs. Reactome analyses identified 7 high-level biological processes with multiple pathways and associated genes that mapped to potential KEs in AOP 272. The gene connectivities were further represented as a network of AEs with associated expression profiles that highlighted patterns of gene expression levels. This study demonstrates the application of transcriptomics data in AOP development and provides information on potential data gaps. Although the approach is new and anticipated to evolve, it shows promise for improving the understanding of underlying mechanisms of disease progression with a long-term vision to be predictive of adverse outcomes.
DOI: 10.17638/datacat.liverpool.ac.uk/2594
title: Comparison of one and two-stage growth approaches for close space sublimation deposition of Sb2Se3 thin film solar cells

description: Data underpinning results in the paper
DOI: 10.6084/m9.figshare.16779834.v1
title: Additional file 1 of Stool preparation under anaerobic conditions contributes to retention of obligate anaerobes: potential improvement for fecal microbiota transplantation

description: Additional file 1.
DOI: 10.6084/m9.figshare.25118093.v1
title: AL&AMOCdata&code.zip

description: The file contains the main code and data for the paper.
DOI: 10.6084/m9.figshare.7866572
title: Demise of mcr-1 and mcr-3.19 mediated by plasmid elimination and ISApl1

description: The sequences in the three files were assembled sequenes of plasmids found in three danghter clones with flye tool based on Nanopore MinION long-read data.
DOI: 10.6084/m9.figshare.16779688.v1
title: Additional file 1 of Copy number variation analysis in Chinese children with complete atrioventricular canal and single ventricle

description: Additional file 1. Table S1. Phenotypes of CHD cohort.
DOI: 10.6084/m9.figshare.7866992.v1
title: Additional file 1: of X-linked inheritances recessive of congenital nystagmus and autosomal dominant inheritances of congenital cataracts coexist in a Chinese family: a case report and literature review

description: Table S1. The panel of genes screened for the family (662) (XLSX 17 kb)
DOI: 10.6084/m9.figshare.16779841
title: Additional file 3 of Identification and validation of a pyroptosis-related prognostic signature for thyroid cancer

description: Additional file 3. The data of the total set.
DOI: 10.6084/m9.figshare.16779771
title: Additional file 2 of Distinct clinical features and prognostic factors of hepatitis C virus-associated non-Hodgkin’s lymphoma: a systematic review and meta-analysis

description: Additional file 2: Table S2. Quality assessment results of included studies.
DOI: 10.6084/m9.figshare.16779844.v1
title: Additional file 4 of Identification and validation of a pyroptosis-related prognostic signature for thyroid cancer

description: Additional file 4. The data of training set.