cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.21302898.v1
title: Supplementary Material for: Evaluations of Skin Permeability of Cannabidiol and Its Topical Formulations by Skin Membrane-Based Parallel Artificial Membrane Permeability Assay and Franz Cell Diffusion Assay

description: <b><i>Introduction:</i></b> Cannabinoids including cannabidiol (CBD) have attracted enormous interest as bioactive ingredients for various dermatological and/or cosmeceutical uses. However, topical applications of cannabinoids might be limited without a fundamental understanding of their skin permeability. Herein, we aimed to evaluate the skin permeability of CBD and its topical formulations using artificial skin membrane assays. The solubility and stability of CBD in various surfactants that are commonly used in topical applications were also evaluated. <b><i>Methods:</i></b> CBD and two CBD-incorporated topical formulations (cream and gel) were prepared for this study. Computational predictions (SwissADME and DERMWIN™) and the parallel artificial membrane permeability assay (PAMPA) were used to evaluate the skin permeability of CBD isolate. The Franz cell diffusion (in vitro release testing) assay was used to evaluate the skin permeability of CBD formulations. The solubility and stability of CBD in surfactants were assessed by high-performance liquid chromatography and mass spectrometry analysis. <b><i>Results:</i></b> CBD isolate showed favorable skin permeability in the SwissADME and DERMWIN™ predictions (−Log Kp of 3.6 and 5.7 cm/s, respectively) and PAMPA (−LogPe value of 5.0 at pH of 6.5 and 7.4). In addition, CBD had higher solubility (378.4 μg/mL) in surfactant Tween 20 as compared to its solubility in polyisobutene. In an acidic environment (pH 5 and 6), Tween 20 maintained the CBD content at 81% and 70% over 30 days, respectively. CBD in the formulations of cream and gel also had moderate skin permeability in the Franz cell diffusion assay. <b><i>Conclusion:</i></b> Data from artificial membrane-based assays support that CBD is a skin permeable cannabinoid and the permeability and stability of its formulations may be influenced by several factors such as surfactant and pH environment. Findings from our study suggest that CBD may have suitable skin permeability for the development of dermatological and/or cosmeceutical applications but further studies using in vivo models are warranted to confirm this.
DOI: 10.6084/m9.figshare.22696348.v1
title: Ruminal bacterial dataset from observational study on ruminal acidosis

description: Dataset containing descriptive, acidosis risk, and center log transformed relative abundance of ruminal bacterial phyla and families data from 287 cows from 36 farms. The study was an observational study with a rumen sample collected via stomach within 3 hours of feeding. The key dietary nutrients from each farm are also provided. <br> The full paper is submitted to Froniters in Micorbiomes Golder, H., J., Rehberger, J., Smith, A., Block, E., and Lean, I. (Submitted). Ruminal bacterial communities differ in early lactation dairy cows with differing risk of ruminal acidosis. Frontiers in Microbiomes. <br> Companion papers include: Golder, H., LeBlanc, S., Duffield, T., Rossow, H., Bogdanich, R., Hernandez, L., et al. (2023). Characterizing ruminal acidosis risk: A multiherd, multicountry study. J. Dairy Sci. 106. doi: https://doi.org/10.3168/jds.2022-22571. <br> Golder, H., Thomson, J., Rehberger, J., Smith, A., Block, E., and Lean, I. (2023). Associations among the genome, rumen metabolome, ruminal bacteria, and milk production in early-lactation Holsteins. J. Dairy Sci. 106. doi: https://doi.org/10.3168/jds.2022-22573.
DOI: 10.6084/m9.figshare.28653308.v1
title: Table. 13. Percentage of Heating Radiation Energy (HRE) by each of the five Greenhouse gases.

description: Table. 13. The ratio of the Heating Radiation Energy (HRE) by each of the five GHG to their total radiated power, as derived from Table. 10.
DOI: 10.6084/m9.figshare.10260527.v1
title: Supplementary Material for: Gastroenteropancreatic High-Grade Neuroendocrine Neoplasms: Histology and Molecular Analysis, Two Sides of the Same Coin

description: <b><i>Background:</i></b> In gastroenteropancreatic (GEP) high-grade neuroendocrine neoplasms (H-NENs), Ki-67 threshold of 55% defines three prognosis subclasses: neuroendocrine tumor (NET) G3, neuroendocrine carcinoma (NEC) &lt;55%, and NEC ≥55%. We investigated whether the molecular profiling of H-NENs differs among these subcategories and evaluated potential therapeutic targets, including PD-L1. <b><i>Methods:</i></b> In GEP-NEN patients, we evaluated: (i) 55% threshold for Ki-67 labeling index for further stratifying NEC and (ii) immunoreactivity and gene mutations by immunohistochemistry and targeted next-generation sequencing (T-NGS). <b><i>Results:</i></b> Fifteen NETs G3 and 39 NECs were identified. Ki-67 labeling index was &lt;55% in 9 NECs and ≥55% in 30 NECs. Gene mutations by NGS (<i>TP53</i>, 32.9%; <i>KRAS</i>, 5.5%; <i>BRAF</i>, 4.1%) were detected in 46.6% NENs, significantly enriched in NEC ≥55% (76.7%) compared to NEC &lt;55% (55.6%) or NET (20.0%). PD-L1 staining in tumor-infiltrating lymphocytes was observed in NEC ≥55% (36.7%; <i>p</i> = 0.03). Median OS was 4.3 years in NET G3, 1.8 years in NEC &lt;55%, and 0.7 years in NEC ≥55% (<i>p &lt;</i>0.0001); it was 2.3 years with NGS wild-type, 0.7 years with ≥1 mutation (<i>p &lt;</i>0.0001), 0.8 years in PD-L1-positive patients, and 1.7 years in PD-L1-negative subjects (<i>p</i> = 0.0004). In multivariate analysis, only the proposed subclassification approach yielded statistically significant differences between groups (NEC &lt;55% vs. NET G3, HR 14.1, 95% CI 2.2–89.8, <i>p</i> = 0.005; NEC ≥55% vs. NET G3, HR 25.8, 95% CI 3.9–169, <i>p</i> = 0.0007). <b><i>Conclusions:</i></b> These findings identify NEC ≥55% as a biologically and prognostically distinct subtype and pave the way for more personalized treatment.
DOI: 10.6084/m9.figshare.5635246.v1
title: Japan Press Freedom Rankings

description: Aggregated historical Freedom House and Reporters Sans Frontiers 'press freedom' rankings for Japan, 2002-2017
DOI: 10.6084/m9.figshare.14399276.v1
title: Gene database of Lactococcus lactis subsp. cremoris KW2

description: <i>Lactococcus lactis</i> is a Gram-positive, non-sporulating and non-motile bacterium important to the diary and cheese making industry. Not an opportunistic pathogen, the bacterium produces lactic acid from lactose that helps to curds milk in cheese making. This work presents the gene database of <i>L. lactis</i> KW2 that comprises gene name, gene function, and gene sequence. Using an in-house MATLAB genome analysis software, the annotated genome sequence of the bacterium downloaded from Genbank was parsed to yield the database. Overall, the gene database should provide foundational information of the genetic repertoire of <i>L. lactis</i> useful for understanding its physiology and metabolism.
DOI: 10.6084/m9.figshare.14414519.v1
title: C41_NST_raw_data

description: Single nucleus RNAseq using NST extraction of Healthy Human Liver. Run on 10X Chromium and cellranger
DOI: 10.60893/figshare.apl.28107698.v1
title: Supplement Material

description: Security checking, construction of atomic logical entanglement channel, and decoding processes.
DOI: 10.6084/m9.figshare.11980332.v1
title: Supplementary Material for: Overcoming Workplace Disability in IBD Patients: An Observational Study

description: <b><i>Background:</i></b> Inflammatory Bowel Disease (IBD) can have considerable effects on employment outcomes because of its disabling character. <b><i>Goals:</i></b> We aimed to investigate the impact of IBD in the workplace and to better understand the need for accommodations and adaptations. <b><i>Study:</i></b> Between November 2017 and March 2018, IBD patients were recruited from outpatient clinics in Christchurch Hospital, New Zealand. The survey assessed employment, the need for workplace accommodations and the difficulty arranging it, insurance, and disability using the item-reduced Inflammatory Bowel Disease Disability Index for self-report (IBD-DI-SR). Data were analyzed using descriptive statistics and multivariate logistic regression modeling. <b><i>Results:</i></b> One hundred twenty-three patients were included (response rate 64%), 112 of whom reported that they experienced symptoms while working (60% female, 71% Crohn’s disease, mean age 41.9 years). Ninety-one percent needed at least 1 workplace accommodation when symptoms were most severe. Almost half of the patients who needed an accommodation had difficulty arranging it. The most needed accommodations were time to go to medical appointments (71%) and easy access to a suitable toilet (71%). Being female, having less effective medication, and being distressed were associated with the need for 2 or more accommodations, difficulty in arranging accommodations, and not asking for needed accommodation. <b><i>Conclusions:</i></b> Many IBD patients need accommodations at work while symptomatic in order to overcome workplace disability, which can be difficult to arrange. Improved resources are needed to inform employees and employers about the disease, the possibilities for workplace accommodations, and practical strategies to request them.
DOI: 10.6084/m9.figshare.17306849.v1
title: Data FIle S3

description: <i>ppk1 </i>sequences from Ca. Accumulibacter and related Rhodocyclaceae genera
DOI: 10.6084/m9.figshare.24005442.v1
title: Supplementary Material for: The impact of long-term conditions and comorbidity patterns on COVID-19 infection and hospitalisation: a cohort study

description: Introduction Older adults are more vulnerable to COVID-19 infections; however, little is known about which comorbidity patterns are related to a higher risk of COVID-19 infection. This study investigated the role of long-term conditions or comorbidity patterns on COVID-19 infection and related hospitalisations. Methods This study included 4,428 individuals from Waves 8 (2016−2017) and 9 (2018−2019) of the English Longitudinal Study of Ageing (ELSA) who also participated in the ELSA COVID-19 Substudy in 2020. Comorbidity patterns were identified using an agglomerative hierarchical clustering method. The relationships between comorbidity patterns or long-term conditions and COVID-19 related outcomes were examined using multivariable logistic regression. Results Among a representative sample of community-dwelling older adults in England, those with cardiovascular disease (CVD) and complex comorbidities had an almost double risk of COVID-19 infection (OR=1.87, 95%CI=1.42−2.46) but not of COVID-19 related hospitalisation. A similar pattern was observed for the heterogeneous comorbidities cluster (OR=1.56, 95%CI=1.24−1.96). The individual investigations of long-term conditions with COVID-19 infection highlighted primary associations with CVD (OR=1.46, 95%CI=1.23−1.74), lung diseases (OR=1.40, 95%CI=1.17−1.69), psychiatric conditions (OR=1.40, 95%CI=1.16−1.68), retinopathy/eye diseases (OR=1.39, 95%CI=1.18−1.64), and arthritis (OR=1.27, 95%CI=1.09−1.48). In contrast, metabolic disorders and diagnosed diabetes were not associated with any COVID-19 outcomes. Discussion/Conclusion This study provides novel insights into the comorbidity patterns that are more vulnerable to COVID-19 infections and hospitalisations, highlighting the vulnerability of those with CVD and other complex comorbidities. These findings facilitate crucial new evidence that should be considered for appropriate screening measures and tailored interventions for older adults in the ongoing global outbreak.
DOI: 10.6084/m9.figshare.28380377.v1
title: Supplementary Material for: Diversity in United States dementia prevention trials: An updated systematic review of eligibility criteria and recruitment strategies

description: Introduction: Given the elevated dementia risk in underrepresented demographic groups in the US—particularly in Latino and Non-Latino Black individuals compared to Non-Latino White individuals—it is vital that these groups are well-represented in dementia prevention research. Eligibility criteria and recruitment strategies may play a key role in promoting participant diversity. The aim of this review was to examine eligibility criteria and recruitment strategies in US dementia prevention trials in light of participant diversity.

Methods: A systematic review was conducted using Medline (including PubMed), Embase, Cochrane Library and CINAHL. We explored the percent White participants for trials using vs. not using a specific eligibility criterion or recruitment strategy using Hodges-Lehmann median difference estimation.

Results: Of forty-four studies meeting the inclusion criteria, twenty-seven reported on racial/ethnic diversity. Analyses demonstrated that criteria regarding cardiovascular disease, pulmonary disease, hearing impairment, and sedentary lifestyle were associated with relatively high participant diversity, while gastro-intestinal/liver disease, motivation to participate, and language proficiency criteria were associated with relatively little diversity. Information on recruitment strategies was often lacking. Three studies described recruitment efforts explicitly aimed at increasing diversity. Recruitment strategies associated with relatively high racial/ethnic diversity included recruitment via referral/word-of-mouth, television/radio advertising, and recruitment at church.

Conclusion: Eligibility criteria could be improved by revisiting and revising how they are defined (e.g. motivation to participate). Regarding recruitment, several recommendations are provided, including 1) lifting barriers to study participation (e.g. through reimbursement), 2) collaborating with community partners, and 3) formally studying the effectiveness of recruitment strategies.
DOI: 10.17632/bdmtpfhn37
title: Tunisia KLEMS
DOI: 10.17632/djtjd6gp5k
title: Turkish women

description: distinct profiles of Turkish women based on their eating behaviors and body perception, and to examine how these profiles moderate the relationship between social media addiction and psychological distress
DOI: 10.6084/m9.figshare.21916008.v1
title: Supplementary Material for: Metformin’s Role in Hyperlactatemia and Lactic Acidosis in ICU Patients: A Systematic Review

description: <b><i>Introduction:</i></b> Metformin-treated patients may experience severe hyperlactatemia or lactic acidosis (LA). LA often requires intensive-care-unit (ICU) treatment, and mortality rates are high. Here, we investigate the impact of renal dysfunction and renal replacement therapy (RRT) on the outcomes of critically ill patients with metformin-associated LA (MALA). Furthermore, we assessed associations between mortality and metformin dose, metformin plasma/serum concentrations, lactate level, and arterial pH. Finally, we investigated whether the recommended classification in MALA, metformin-unrelated LA, metformin-induced LA, and LA in metformin therapy appears useful in this regard. <b><i>Methods:</i></b> We performed a retrospective analysis based on a systematic PubMed search for publications on hyperlactatemia/LA in metformin-treated ICU patients from January 1995 to February 2020. Case-level data including demographics and clinical conditions were extracted, and logistic regression analyses were performed. <b><i>Results:</i></b> A total of 92 ICU patients were reported. Two of these patients had no comorbidities interfering with lactate metabolism. In the overall group, arterial pH, lactate levels, and metformin plasma/serum concentrations were similar in survivors versus non-survivors. Ingested daily metformin doses and plasma/serum creatinine levels were significantly higher in survivors versus non-survivors (<i>p</i> = 0.007 vs. <i>p</i> = 0.024, respectively). Higher plasma/serum creatinine levels, higher lactate levels, and lower arterial pH were all associated with patients receiving RRT (all <i>p</i> &lt; 0.05). Overall mortality was 22% (20 out of 92 patients) and did not differ between the RRT and non-RRT groups. <b><i>Conclusion:</i></b> Mortality is high in ICU patients with metformin-associated hyperlactatemia/LA. Unexpectedly, higher ingested metformin dose and plasma/serum creatinine were associated with a better outcome. Survival was similar in patients with or without need for RRT.
DOI: 10.6084/m9.figshare.28730861.v1
title: Suplemento 1. Selección de los ítems de las versiones de EU Kids online, Global Kids Online y Livingstone et al. (2017) sobre las dimensiones de mediación parental online de cada cuestionario.

description: El único instrumento de evaluación utilizado es el cuestionario integrado y emparejado para la evaluación de las estrategias de mediación parental para niños y familias/tutores legales. Para ello se han analizado conjuntamente ítems de las versiones disponibles y recientes del proyecto EU Kids Online (http://www.eukidsonline.net/) en su versión 2017 (para niños), Global Kids Online (http://globalkidsonline.net/) (versión niños y tutores legales) y del trabajo de Livingstone et al. 2017 (donde solo se evalúa a los tutores legales). El proceso de construcción puede consultarse en el Anexo/Suplemento A/1. Aunque los ítems son muy similares en cada una de las versiones, existen algunas diferencias, tanto en el número de ítems que componen cada dimensión como en las escalas de respuesta. El principio rector ha sido realizar una propuesta de máximos que combine todos los ítems posibles de las tres versiones, a excepción del ítem 18 de mediación restrictiva, que no se ha incluido en los análisis estadísticos por tener una escala de respuesta diferente al resto de ítems de la dimensión (Ver suplemento 1). Así, todos los ítems han sido añadidos a esta versión y emparejados para las fórmulas del niño y de la familia/tutor.
DOI: 10.26188/28910213
title: Autocycler: subsampled read sets

description: This archive contains the ONT read subsets used to generate the assemblies provided in the associated 'Autocycler: assemblies and reference genomes' dataset. Each subset represents ~50× coverage and was used as input to multiple long-read assembly tools during the Autocycler benchmarking study. Reads were basecalled with Dorado v0.9.5 using the sup-v5 model.See github.com/rrwick/Autocycler-paper for more details.
DOI: 10.6084/m9.figshare.24785211.v1
title: Supplementary Material for: Disease burden of colorectal cancer in China from 1990 to 2019: Age and sex-specific time trends and 10-year forecast

description: Introduction: Colorectal cancer (CRC) is the third most prevalent malignant tumor worldwide and the second leading cause of cancer-related death.Aimed to report the disease burden of CRC in China from 1990 to 2019 and predict the trend of mortality burden over the next 10 years.
Methods: The age-period-cohort (APC) model was implemented to analyze the trends of mortality from CRC in China from 1990 to 2019, and the autoregressive integrated moving average (ARIMA) model was used to predict the trends of CRC incidence and mortality from 2020 to 2029.
Results: From 1990 to 2019, the incidence of CRC in China increased from 105,911 cases (95% uncertainty interval (UI): 93,808-119,021) to 607,900 cases (95% UI: 521,805-708,420). The age-standardized incidence rate (ASIR) increased from 12.52 per 100,000 (95% UI: 11.15-14.03) to 30.55 per 100,000 (95% UI: 26.37-35.5), with an estimated annual percentage change (EAPC) of 3.66 (95% confidence interval (CI): 3.37-3.95), showing an upward trend. The age-standardized mortality rate (ASMR) increased from 10.18 per 100,000 (95% UI: 9.03-11.37) to 13.86 per 100,000 (95% UI: 11.92-16.01), with an EAPC of 1.39 (95% CI: 1.14-1.63), also showing an upward trend. The age group with the highest incidence and mortality in 2019 was 65-69 years old for both sexes, and the age group with the highest mortality was 70-74 years old. Males had higher relative risks of incidence and mortality than females. Low-calcium diet was the risk factor for both sexes and females alone in 1990, while low-milk diet was the risk factor in 2019; however, smoking remained the risk factor for males. The ARIMA model predicted an increase in both disease and mortality burden of CRC over the next 10 years.
Conclusion: The disease and mortality burden of CRC in China showed an overall upward trend from 1990 to 2019, with higher burden in males than females, and the situation remains extremely severe in the next decade.
DOI: 10.6084/m9.figshare.26461363.v1
title: Multi-omics linkage analysis for the striatopallidal (<i>Drd1</i>) and the striatopallidal (<i>Drd2</i>) neurons from huamn striatum

description: multi-omic snATAC-/snRNA-seq dataset from the striatum region of the brain. Striata were collected from eight genetically diverse inbred mouse strains, representing the founders of the Diversity Outbred (DO) and Collaborative Cross populations used for genetic analysis of complex traits.<br><b>Methods</b>Enhlink analyses were performed independently using snATAC-seq alone, and either separating Drd1 and drd2 cells into two clusters or by combining both neurons together and using the Drd1/2 status as covariates (combined analysis). The analysis was repeated to correlate peak activity with the gene expression matrix from the snRNA-seq. Then common peaks between the modalities were then identified.<b>File Description</b>Each BEDPE file contains genomic links using the 6 first columns to define the enhancer (three first columns) and the promoter (the following three columns). Also, each file refers to a specific cell type written in the file name. The <i>drd</i> extension in the file name designates the combined analyses and the merged extension designates the merged analyses<b>Software</b>https://gitlab.com/Grouumf/enhlinktools<b>Citation</b>https://genomebiology.biomedcentral.com/articles/10.1186/s13059-024-03374-9
DOI: 10.6084/m9.figshare.28621208.v1
title: RNA sequences of cochlear hair cells after ibrutinib treatment

description: These findings confirm ibrutinib’s ototoxicity and highlight the protective role of GPR83 in ibrutinib-induced hearing loss, supporting future clinical investigations into Z-VAD-FMK and GPR83 as interventions for ibrutinibor other chemotherapeuticdrug-induced ototoxicity.
DOI: 10.6084/m9.figshare.19499507.v1
title: patches and local annotations, slide 116, zoom 248x248 um2

description: patches and local annotations: data for slide with ID of the last 3 characters of the file name: local annotations in csv format and a folder with patches at zoom level indicated at the 6th character of the file name
DOI: 10.6084/m9.figshare.5371627.v2
title: Research crowdfunding interview with UWA - Lindy Fitzgerald

description: On 19 August 2016, I conducted an interview with Lindy Fitzgerald of University of Western Australia. Lindy had run an interesting crowdfunding campaign, to raise funds to attend Homeward Bound, a women in science leadership program. <br>This data set contains the interview (MP3), a transcript of the interview (PDF) and two consent forms (JPG) for the interview and for the public release of the information.<br>I would like to take this opportunity to thank Lindy for her interview, and for agreeing to make it public.