cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.9899723.v1
title: Oral health profile of participants of an elderly cohabitation program in the state of Santa Catarina, Brazil

description: Abstract Introduction Cohabitation and social interaction programs have been shown to enhance several aspects of the quality of life of the elderly. Objective This observational study assessed the oral health and oral health perception of participants of an elderly cohabitation program in the state of Santa Catarina, Brazil. Material and method Calibrated dental students examined/interviewed 235 participants of the program. The oral examination considered Decayed, Missing, and Filled Teeth (DMFT) index, Community Periodontal Index (CPI), Periodontal Attachment Loss (PAL), use and need of prostheses, and presence of oral mucosal lesions. Oral health perception was verified with the Geriatric Oral Health Assessment Index (GOHAI) questionnaire. Data were analyzed with descriptive statistics and chi-square test (α=0.05). Result The mean DMFT index was 24.3 teeth, with emphasis on the ‘Missing’ category. Upper and lower prosthetic needs were 53.6 and 71.1%, respectively. Fifty-five per cent of participants presented oral mucosal lesions. Moderate oral health perception prevailed (43%), with mean GOHAI score of 29.9. The negative perception on physical and pain/discomfort dimensions was statistically associated with lower prosthetic need (p&lt;0.05). Conclusion The participants of the cohabitation program presented poor oral health and prevalence of moderate oral health perception. Lower prosthetic need was associated with negative perception.
DOI: 10.6084/m9.figshare.9899729
title: Evaluation of antibacterial activity of different intraradicular retainers against Enterococcus faecalis: in vitro evaluation

description: Abstract Introduction The ultimate goal of endodontic treatment is the eradication of microorganism from the root canal space, or at least their reduction to levels compatible with periradicular tissue health since after endodontic treatment colonies of residual microorganisms may be present in the dentinal tubules and cementum. Objective To evaluate the antibacterial activity of different fiber posts in the root canal system of bovine teeth. Material and method Here, 90 uniradicular bovine teeth were randomly assigned after complete endodontic therapy. The samples were unthreaded, as well as had their conduits prepared for the cementation of the intracanal retainers. Subsequently, the teeth were exposed to Enterococcus faecalis by means of the assembly of a device, which allowed bacterial infiltration. The data of the amount by colony forming unit (CFU) per ml assay were analyzed by one-way ANOVA followed by Tukey’s HSD post hoc test (p&lt;0,05). Result After the 14-day period, the group that presented the highest bacterial infiltration was the control group, which did not contain any type of intrarradicular retainer, followed by G1-FV (group of contained fiber glass post) and G2- FC (group containing carbon fiber reinforced post). Results of the smallest degree of bacterial recovery was found in the G3-Ni-Cr and G4-Cu-Al groups, which contained metallic intracanal retainers by nickel-chromium and copper-aluminum alloys respectively. Conclusion The intracanal retainers evaluated here presented different antimicrobial effects. Thus, the use of intracanal post with better antimicrobial results, favors greater chances of success in rehabilitation treatments.
DOI: 10.6084/m9.figshare.9899729.v1
title: Evaluation of antibacterial activity of different intraradicular retainers against Enterococcus faecalis: in vitro evaluation

description: Abstract Introduction The ultimate goal of endodontic treatment is the eradication of microorganism from the root canal space, or at least their reduction to levels compatible with periradicular tissue health since after endodontic treatment colonies of residual microorganisms may be present in the dentinal tubules and cementum. Objective To evaluate the antibacterial activity of different fiber posts in the root canal system of bovine teeth. Material and method Here, 90 uniradicular bovine teeth were randomly assigned after complete endodontic therapy. The samples were unthreaded, as well as had their conduits prepared for the cementation of the intracanal retainers. Subsequently, the teeth were exposed to Enterococcus faecalis by means of the assembly of a device, which allowed bacterial infiltration. The data of the amount by colony forming unit (CFU) per ml assay were analyzed by one-way ANOVA followed by Tukey’s HSD post hoc test (p&lt;0,05). Result After the 14-day period, the group that presented the highest bacterial infiltration was the control group, which did not contain any type of intrarradicular retainer, followed by G1-FV (group of contained fiber glass post) and G2- FC (group containing carbon fiber reinforced post). Results of the smallest degree of bacterial recovery was found in the G3-Ni-Cr and G4-Cu-Al groups, which contained metallic intracanal retainers by nickel-chromium and copper-aluminum alloys respectively. Conclusion The intracanal retainers evaluated here presented different antimicrobial effects. Thus, the use of intracanal post with better antimicrobial results, favors greater chances of success in rehabilitation treatments.
DOI: 10.6084/m9.figshare.9899732
title: Effect of techniques, trays and materials on accuracy of impressions clinically made

description: Abstract Introduction Making accurate and dimensionally stable impressions to duplicate oral conditions and tooth morphology is an essential step of prosthetic dentistry for fabricating well-fitted indirect restorations and, consequently, ensure the longevity and success of the treatment. Several authors describe pros and cons of different impression techniques, although there is no unanimity among them about the best one. Objective This study evaluated casts’ accuracy made by different impression techniques, trays and materials. Material and method 10 patients were selected and 20 impressions from teeth #13 to #16 were performed using single-step (SS) and two-step techniques, made with metal stock and customized acrylic resin partial trays, vinyl polysiloxane and condensation silicone rubbers. Type IV gypsum was used to pour the casts. Three photographs of each patient (baseline), as their respective gypsum casts, were taken, measured in their interested buccal surface area. Comparisons of area values among experimental groups and baseline were performed. Data showed adherence to normal curve, being submitted to 3-way ANOVA/Bonferroni test (α=.05). Result Technique produced significant differences (P=0.02). SS technique was more accurate than BUR one (P=0.003; 95=1.22 to 5.98), but both resulted in similar casts to PVC, MOV and NR techniques, which were similar to each other (P&gt;0.05). Conclusion SS technique showed the closest absolute values to baseline.
DOI: 10.6084/m9.figshare.9899732.v1
title: Effect of techniques, trays and materials on accuracy of impressions clinically made

description: Abstract Introduction Making accurate and dimensionally stable impressions to duplicate oral conditions and tooth morphology is an essential step of prosthetic dentistry for fabricating well-fitted indirect restorations and, consequently, ensure the longevity and success of the treatment. Several authors describe pros and cons of different impression techniques, although there is no unanimity among them about the best one. Objective This study evaluated casts’ accuracy made by different impression techniques, trays and materials. Material and method 10 patients were selected and 20 impressions from teeth #13 to #16 were performed using single-step (SS) and two-step techniques, made with metal stock and customized acrylic resin partial trays, vinyl polysiloxane and condensation silicone rubbers. Type IV gypsum was used to pour the casts. Three photographs of each patient (baseline), as their respective gypsum casts, were taken, measured in their interested buccal surface area. Comparisons of area values among experimental groups and baseline were performed. Data showed adherence to normal curve, being submitted to 3-way ANOVA/Bonferroni test (α=.05). Result Technique produced significant differences (P=0.02). SS technique was more accurate than BUR one (P=0.003; 95=1.22 to 5.98), but both resulted in similar casts to PVC, MOV and NR techniques, which were similar to each other (P&gt;0.05). Conclusion SS technique showed the closest absolute values to baseline.
DOI: 10.6084/m9.figshare.14327099
title: The LINC01119-SOCS5 axis as a critical theranostic in triple-negative breast cancer

description: The development of triple-negative breast cancer (TNBC) is critically regulated by certain tumor-microenvironment-associated cells called mesenchymal stem/stromal cells (MSCs), which we and others have shown promoted TNBC progression by activating pro-malignant signaling in neighboring cancer cells. Characterization of these cascades will better our understanding of TNBC biology, and stands to bring about therapeutics that can eliminate the morbidity and mortality associated with advanced disease. Here, we focused on the emerging class of non-coding RNAs called long non-coding RNAs or lncRNAs, and utilized a MSC-supported TNBC progression model to identify specific family members of functional relevance to TNBC pathogenesis. Indeed, although some have been described to play functional roles in TNBC, activities for lncRNAs as mediators of tumor-microenvironment-driven TNBC development remain to be fully explored. We report that MSCs stimulated robust expression of LINC01119 in TNBC cells, which in turn induced suppressor of cytokine signaling 5 (SOCS5), leading to accelerated cancer cell growth and tumorigenesis. We show that LINC01119 and SOCS5 exhibited tight correlation across multiple breast cancer gene sets and that they were highly enriched in TNBC patient cohorts. Importantly, we present evidence that the LINC01119-SOCS5 axis served as a powerful prognostic indicator of adverse outcome in TNBC patients, and we demonstrate that its repression severely impaired cancer cell growth. Altogether, our findings identify LINC01119 as a major driver of TNBC development, and delineate critical non-coding RNA theranostics of potential translational utility in the management of advanced TNBC, a class of tumors in most need of effective and targeted therapy.
DOI: 10.6084/m9.figshare.14327099.v1
title: The LINC01119-SOCS5 axis as a critical theranostic in triple-negative breast cancer

description: The development of triple-negative breast cancer (TNBC) is critically regulated by certain tumor-microenvironment-associated cells called mesenchymal stem/stromal cells (MSCs), which we and others have shown promoted TNBC progression by activating pro-malignant signaling in neighboring cancer cells. Characterization of these cascades will better our understanding of TNBC biology, and stands to bring about therapeutics that can eliminate the morbidity and mortality associated with advanced disease. Here, we focused on the emerging class of non-coding RNAs called long non-coding RNAs or lncRNAs, and utilized a MSC-supported TNBC progression model to identify specific family members of functional relevance to TNBC pathogenesis. Indeed, although some have been described to play functional roles in TNBC, activities for lncRNAs as mediators of tumor-microenvironment-driven TNBC development remain to be fully explored. We report that MSCs stimulated robust expression of LINC01119 in TNBC cells, which in turn induced suppressor of cytokine signaling 5 (SOCS5), leading to accelerated cancer cell growth and tumorigenesis. We show that LINC01119 and SOCS5 exhibited tight correlation across multiple breast cancer gene sets and that they were highly enriched in TNBC patient cohorts. Importantly, we present evidence that the LINC01119-SOCS5 axis served as a powerful prognostic indicator of adverse outcome in TNBC patients, and we demonstrate that its repression severely impaired cancer cell growth. Altogether, our findings identify LINC01119 as a major driver of TNBC development, and delineate critical non-coding RNA theranostics of potential translational utility in the management of advanced TNBC, a class of tumors in most need of effective and targeted therapy.
DOI: 10.6084/m9.figshare.9927146
title: Glass fiber post treatment – does it influence resin cement bond strength?

description: Abstract Introduction Glass-fiber posts are used in order to improve the retention of restorations in endodontically treated teeth. Objective To evaluate the bond strength of glass-fiber posts submitted to different surface treatments and cemented to the root canal dentin with self-adhesive resin cement. Material and method Thirty roots of human canines were prepared and divided according to two factors: surface treatments (silane, 35% hydrogen peroxide, or sodium bicarbonate) and root thirds (cervical and middle thirds). The glass-fiber posts were cemented with self-adhesive resin cement (RelyX U200). After 24 h, the specimens were prepared for microtensile bond strength test (hourglass format), fracture pattern and micromorphological assessment by scanning electronic microscopy, in order to measure the cement line. Result The data (MPa and µm) were submitted to two-way ANOVA and Tukey’s test (α = 5%). The surface treatments influenced the bond strength of the posts cemented with self-adhesive resin cement (p&lt;0.00). The mean bond strength (standard deviations) differed according to the region of root dentin (p&lt;0.00): the cervical region (Control: 19.16MPa (3.71); Silane: 25.65MPa (4.04); Hydrogen peroxide: 24.43MPa (3.16); Sodium bicarbonate: 37.42MPa (8.27)) showed higher bond strength values than the middle third of the root (Control: 14.66MPa (4.65); Silane: 12.52MPa (5.03); Hydrogen peroxide: 10.64MPa (3.33); Sodium bicarbonate: 10.87MPa (2.49)). Conclusion Treatment of the glass-fiber post surface with chemical and physical agents increased the bond strength of the cement-post-dentin interface in the cervical third and the treatment with Sodium bicarbonate showed better results in bond strength.
DOI: 10.6084/m9.figshare.9927146.v1
title: Glass fiber post treatment – does it influence resin cement bond strength?

description: Abstract Introduction Glass-fiber posts are used in order to improve the retention of restorations in endodontically treated teeth. Objective To evaluate the bond strength of glass-fiber posts submitted to different surface treatments and cemented to the root canal dentin with self-adhesive resin cement. Material and method Thirty roots of human canines were prepared and divided according to two factors: surface treatments (silane, 35% hydrogen peroxide, or sodium bicarbonate) and root thirds (cervical and middle thirds). The glass-fiber posts were cemented with self-adhesive resin cement (RelyX U200). After 24 h, the specimens were prepared for microtensile bond strength test (hourglass format), fracture pattern and micromorphological assessment by scanning electronic microscopy, in order to measure the cement line. Result The data (MPa and µm) were submitted to two-way ANOVA and Tukey’s test (α = 5%). The surface treatments influenced the bond strength of the posts cemented with self-adhesive resin cement (p&lt;0.00). The mean bond strength (standard deviations) differed according to the region of root dentin (p&lt;0.00): the cervical region (Control: 19.16MPa (3.71); Silane: 25.65MPa (4.04); Hydrogen peroxide: 24.43MPa (3.16); Sodium bicarbonate: 37.42MPa (8.27)) showed higher bond strength values than the middle third of the root (Control: 14.66MPa (4.65); Silane: 12.52MPa (5.03); Hydrogen peroxide: 10.64MPa (3.33); Sodium bicarbonate: 10.87MPa (2.49)). Conclusion Treatment of the glass-fiber post surface with chemical and physical agents increased the bond strength of the cement-post-dentin interface in the cervical third and the treatment with Sodium bicarbonate showed better results in bond strength.
DOI: 10.6084/m9.figshare.9927143
title: Influence of the zirconia cleaning method on prosthesis adhesion after saliva contamination

description: Abstract Introduction An important clinical factor related to the adhesion of ceramic restorations is the contamination with saliva before cementation. The zirconia has strong affinity with the ions present in the saliva which can interfere in the cementation adhesion. Objective to evaluate the influence of the zirconia cleaning methods on the dentin adhesion system after contamination with saliva. Material and method Eight zirconia samples (4x11x3 mm) were cut from pre-sintered (3Y-TZP, In-Ceram-VITA®) zirconia blocks, sintered and sandblasted with alumina particles. After sintering the samples were washed in distilled water on the ultrasound and randomly divided into two groups based on the type of adhesion cement RelyX U200 Clicker® (group R) or Multilink N® (group M). Before cementation the samples were divided into four subgroups (n = 10) according to the cleaning and cementation methods: RG1 and MGI (without contamination with saliva); RG2 and MG2 (without contamination and cleaning with Ivoclean®); RG3 and MG3 (with contamination and cleaning with H2O); RG4 and MG4 (with contamination and cleaning with Ivoclean®). After cementation, the samples were stored in water (37 °C for 10 days). The adhesion strength was determined by the shear strength test. Result The results showed that the highest and lowest resistance were from the RG2 and MG2 subgroups, respectively. Among the samples cemented with RelyX® only the RG4 subgroup presented a difference in adhesion resistance (p = 0.018) in relation to the other subgroups. Among the subgroups cemented with Multilink N®, there was no statistical difference (p&gt; 0.05) in shear strength. Conclusion Based on the results it was possible to conclude that the commercial cleaning agent Ivoclean® was not effective in the decontamination and did not influence the shear strength.
DOI: 10.6084/m9.figshare.9927143.v1
title: Influence of the zirconia cleaning method on prosthesis adhesion after saliva contamination

description: Abstract Introduction An important clinical factor related to the adhesion of ceramic restorations is the contamination with saliva before cementation. The zirconia has strong affinity with the ions present in the saliva which can interfere in the cementation adhesion. Objective to evaluate the influence of the zirconia cleaning methods on the dentin adhesion system after contamination with saliva. Material and method Eight zirconia samples (4x11x3 mm) were cut from pre-sintered (3Y-TZP, In-Ceram-VITA®) zirconia blocks, sintered and sandblasted with alumina particles. After sintering the samples were washed in distilled water on the ultrasound and randomly divided into two groups based on the type of adhesion cement RelyX U200 Clicker® (group R) or Multilink N® (group M). Before cementation the samples were divided into four subgroups (n = 10) according to the cleaning and cementation methods: RG1 and MGI (without contamination with saliva); RG2 and MG2 (without contamination and cleaning with Ivoclean®); RG3 and MG3 (with contamination and cleaning with H2O); RG4 and MG4 (with contamination and cleaning with Ivoclean®). After cementation, the samples were stored in water (37 °C for 10 days). The adhesion strength was determined by the shear strength test. Result The results showed that the highest and lowest resistance were from the RG2 and MG2 subgroups, respectively. Among the samples cemented with RelyX® only the RG4 subgroup presented a difference in adhesion resistance (p = 0.018) in relation to the other subgroups. Among the subgroups cemented with Multilink N®, there was no statistical difference (p&gt; 0.05) in shear strength. Conclusion Based on the results it was possible to conclude that the commercial cleaning agent Ivoclean® was not effective in the decontamination and did not influence the shear strength.
DOI: 10.6084/m9.figshare.9956774.v1
title: Fracture strength of monocrystalline and polycrystalline ceramic brackets during archwire torque

description: Abstract Introduction In recent years, there has been an increasing demand for esthetic treatments, especially among orthodontic patients. Objective This study determined the fracture strength of monocrystalline and polycrystalline ceramic brackets of different manufacturers during archwire torque. Material and method Sixty ceramic brackets (Roth, right upper central incisors, 0.022 x 0.028-inch slot) were allocated into two groups (30 specimens per group) according to the type of ceramics: monocrystalline and polycrystalline. Subsequently, the groups were divided into three subgroups (n = 10) according to the manufacturer: Orthometric, Eurodonto and Ortho Technology. Sixty PVC cylinders were filled with chemically activated acrylic resin (CAAR), the brackets were fixed with CAAR onto the cylinder surface and the excess material was used to partially cover the base of the bracket. After 24h, the U-shaped wire base (0.019 x 0.025 inches; 6 mm height and width) was inserted into the bracket slot and fixed thereon with a stainless-steel wire. Vertical folds were made at the ends of the “U” to support the universal test machine chisel. The fracture strength test was performed at a speed of 1.0 mm/min until fracture into a universal test machine (Instron). The data were recorded, transformed into g.mm and submitted to two-way ANOVA followed by Tukey’s post-hoc test (SAS Institute Inc., Cary, NC, USA, version 9.3) (α=5%). Result Monocrystalline brackets showed a higher fracture strength than polycrystalline brackets, regardless of the manufacturer (p&lt;0.05). The highest fracture strength values were observed in Ortho Technology and Orthometric brackets, with no significant difference between them (p&gt;0.05). Conclusion Monocrystalline ceramic brackets have a higher fracture strength than polycrystalline brackets, with significant manufacturer-dependent differences.
DOI: 10.6084/m9.figshare.9956774
title: Fracture strength of monocrystalline and polycrystalline ceramic brackets during archwire torque

description: Abstract Introduction In recent years, there has been an increasing demand for esthetic treatments, especially among orthodontic patients. Objective This study determined the fracture strength of monocrystalline and polycrystalline ceramic brackets of different manufacturers during archwire torque. Material and method Sixty ceramic brackets (Roth, right upper central incisors, 0.022 x 0.028-inch slot) were allocated into two groups (30 specimens per group) according to the type of ceramics: monocrystalline and polycrystalline. Subsequently, the groups were divided into three subgroups (n = 10) according to the manufacturer: Orthometric, Eurodonto and Ortho Technology. Sixty PVC cylinders were filled with chemically activated acrylic resin (CAAR), the brackets were fixed with CAAR onto the cylinder surface and the excess material was used to partially cover the base of the bracket. After 24h, the U-shaped wire base (0.019 x 0.025 inches; 6 mm height and width) was inserted into the bracket slot and fixed thereon with a stainless-steel wire. Vertical folds were made at the ends of the “U” to support the universal test machine chisel. The fracture strength test was performed at a speed of 1.0 mm/min until fracture into a universal test machine (Instron). The data were recorded, transformed into g.mm and submitted to two-way ANOVA followed by Tukey’s post-hoc test (SAS Institute Inc., Cary, NC, USA, version 9.3) (α=5%). Result Monocrystalline brackets showed a higher fracture strength than polycrystalline brackets, regardless of the manufacturer (p&lt;0.05). The highest fracture strength values were observed in Ortho Technology and Orthometric brackets, with no significant difference between them (p&gt;0.05). Conclusion Monocrystalline ceramic brackets have a higher fracture strength than polycrystalline brackets, with significant manufacturer-dependent differences.