cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.5281/zenodo.4068459
title: Dataset related to the article "Plasma phospholipid dysregulation in patients with cystathionine-β synthase deficiency

description: This record contains raw data related to the article "Plasma phospholipid dysregulation in patients with cystathionine-β synthase deficiency" <strong>ABSTRACT</strong> <strong>Background & Aims:</strong> Patients with cystathionine β-synthase deficiency (CBSD) exhibit high circulating levels of homocysteine and enhanced lipid peroxidation. Because enhanced homocysteine plays key roles in methylation reactions that govern lipid metabolism, we have characterized the plasma lipidome in CBSD patients. <strong>Methods and results:</strong> Using an ultra-high-performance liquid chromatography-electrospray ionization-quadrupole-time of flight- mass spectrometry method, plasma lipids were determined with an untargeted lipidomics approach in 11 CBSD patients and 11 matched healthy subjects (CTRL). Compared to CTRL, CBSD patients had a higher medium and long-chain polyunsaturated fatty acids (PUFA) content in phosphatidylethanolamine (PE) and lysophosphatidylethanolamine (LPE) species (p&lt;0.02), and depletion of phosphatidylcholine (PC; p=0.02) and of lysophosphatidylcholine (LPC; p=0.003) species containing docosahexaenoic acid (DHA), suggesting impaired phosphatidylethanolamine-N-methyltransferase (PEMT) activity. PEMT needs methyl groups to convert PE into PC, S-adenosylmethionine (SAM) and S-adenosylhomocysteine (SAH). Whole blood SAM and SAH concentrations by liquid chromatography tandem mass spectrometry were 1.4-fold (p=0.015) and 5.3-fold (p=0.003) higher in CBSD patients than in CTRL. A positive correlation between SAM/SAH and PC/PE ratios (r=0.520; p=0.019) was found. <strong>Conclusions:</strong> A novel biochemical abnormality in CBSD patients consisting in depletion of PC and LPC species containing DHA and accumulation of PUFA in PE and LPE species is revealed by this lipidomic approach. Changes in plasma SAM and SAH concentrations are associated with such phospholipid dysregulation. Given the key role of DHA in thrombosis prevention, depletion of PC species containing DHA in CBSD patients provides a new direction to understand the poor cardiovascular outcome of patients with homocystinuria and hyperhomocysteinemia. The data are those produced at Centro Cardiologico Monzino
DOI: 10.5281/zenodo.4068458
title: Dataset related to the article "Plasma phospholipid dysregulation in patients with cystathionine-β synthase deficiency

description: This record contains raw data related to the article "Plasma phospholipid dysregulation in patients with cystathionine-β synthase deficiency" <strong>ABSTRACT</strong> <strong>Background & Aims:</strong> Patients with cystathionine β-synthase deficiency (CBSD) exhibit high circulating levels of homocysteine and enhanced lipid peroxidation. Because enhanced homocysteine plays key roles in methylation reactions that govern lipid metabolism, we have characterized the plasma lipidome in CBSD patients. <strong>Methods and results:</strong> Using an ultra-high-performance liquid chromatography-electrospray ionization-quadrupole-time of flight- mass spectrometry method, plasma lipids were determined with an untargeted lipidomics approach in 11 CBSD patients and 11 matched healthy subjects (CTRL). Compared to CTRL, CBSD patients had a higher medium and long-chain polyunsaturated fatty acids (PUFA) content in phosphatidylethanolamine (PE) and lysophosphatidylethanolamine (LPE) species (p&lt;0.02), and depletion of phosphatidylcholine (PC; p=0.02) and of lysophosphatidylcholine (LPC; p=0.003) species containing docosahexaenoic acid (DHA), suggesting impaired phosphatidylethanolamine-N-methyltransferase (PEMT) activity. PEMT needs methyl groups to convert PE into PC, S-adenosylmethionine (SAM) and S-adenosylhomocysteine (SAH). Whole blood SAM and SAH concentrations by liquid chromatography tandem mass spectrometry were 1.4-fold (p=0.015) and 5.3-fold (p=0.003) higher in CBSD patients than in CTRL. A positive correlation between SAM/SAH and PC/PE ratios (r=0.520; p=0.019) was found. <strong>Conclusions:</strong> A novel biochemical abnormality in CBSD patients consisting in depletion of PC and LPC species containing DHA and accumulation of PUFA in PE and LPE species is revealed by this lipidomic approach. Changes in plasma SAM and SAH concentrations are associated with such phospholipid dysregulation. Given the key role of DHA in thrombosis prevention, depletion of PC species containing DHA in CBSD patients provides a new direction to understand the poor cardiovascular outcome of patients with homocystinuria and hyperhomocysteinemia. The data are those produced at Centro Cardiologico Monzino
DOI: 10.5281/zenodo.4074958
title: Radar observations of traveling ionospheric disturbances produced by high power HF radio waves and natural sources

description: The zip-archived data underlying the publication.
DOI: 10.5281/zenodo.4074957
title: Radar observations of traveling ionospheric disturbances produced by high power HF radio waves and natural sources

description: The zip-archived data underlying the publication.
DOI: 10.25392/leicester.data.13067519
title: Temporal and spatial contiguity are necessary for competition between events

description: Each sheet contains the data set of the data analysed in each of the experiments. Below the spreadsheet, there is a note explaining what each column represents.
DOI: 10.25392/leicester.data.13067519.v1
title: Temporal and spatial contiguity are necessary for competition between events

description: Each sheet contains the data set of the data analysed in each of the experiments. Below the spreadsheet, there is a note explaining what each column represents.
DOI: 10.5281/zenodo.4075154
title: Inducible TDG knockout models to study epigenetic regulation

description: Mechanistic and functional studies by gene disruption or editing approaches often suffer from confounding effects like compensatory cellular adaptations generated by clonal selection. These issues become particularly relevant when studying factors directly involved in genetic or epigenetic maintenance. To provide a genetic tool for functional and mechanistic investigation of DNA repair mediated active DNA demethylation, we generated a <em>Tdg </em>minigene model in mice and mouse embryonic stem cells (ESCs). The floxed <em>miniTdg</em> is rapidly and reliably excised by tamoxifen-induced Cre expression in mice and ESCs, depleting TDG to undetectable levels within 24 hours of induction. We describe the functionality of the engineered <em>miniTdg</em> in mouse and ESCs (TDGiKO ESCs) and validate the pluripotency and differentiation potential of TDGiKO ESCs as well as the phenotype of induced TDG depletion. The controlled and rapid depletion of TDG allows for a precise manipulation at any time point in multistep experimental procedures as presented here for neuronal differentiation <em>in vitro</em>. Thus, we provide a thoroughly validate d genetic tool for the functional and mechanistic investigation of TDG in active DNA (de)methylation and/or DNA repair with minimal interference from adaptive effects and clonal selection.
DOI: 10.5281/zenodo.3957874
title: Inducible TDG knockout models to study epigenetic regulation

description: Mechanistic and functional studies by gene disruption or editing approaches often suffer from confounding effects like compensatory cellular adaptations generated by clonal selection. These issues become particularly relevant when studying factors directly involved in genetic or epigenetic maintenance. To provide a genetic tool for functional and mechanistic investigation of DNA repair mediated active DNA demethylation, we generated a <em>Tdg </em>minigene model in mice and mouse embryonic stem cells (ESCs). The floxed <em>miniTdg</em> is rapidly and reliably excised by tamoxifen-induced Cre expression in mice and ESCs, depleting TDG to undetectable levels within 24 hours of induction. We describe the functionality of the engineered <em>miniTdg</em> in mouse and ESCs (TDGiKO ESCs) and validate the pluripotency and differentiation potential of TDGiKO ESCs as well as the phenotype of induced TDG depletion. The controlled and rapid depletion of TDG allows for a precise manipulation at any time point in multistep experimental procedures as presented here for neuronal differentiation <em>in vitro</em>. Thus, we provide a thoroughly validate d genetic tool for the functional and mechanistic investigation of TDG in active DNA (de)methylation and/or DNA repair with minimal interference from adaptive effects and clonal selection.
DOI: 10.5281/zenodo.4075153
title: Cited references and records of Imperial College London institutional repository grey literature

description: Cited references (all time) to items published under Imperial College London's grey literature DOI prefix 10.25561 and bibliographic data of deposited Reports in the repository (2016-2020).
DOI: 10.5281/zenodo.4075152
title: Cited references and records of Imperial College London institutional repository grey literature

description: Cited references (all time) to items published under Imperial College London's grey literature DOI prefix 10.25561 and bibliographic data of deposited Reports in the repository (2016-2020).
DOI: 10.7284/130612
title: ADCP (Acoustic Doppler Current Profiler) data collected during research cruise AR30-05 using a Hawaii UHDAS instrument system onboard the platform RV Neil Armstrong

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/130615
title: CTD (Conductivity, Temperature, Depth) data collected during research cruise AR30-05 using a Sea-Bird SBE-911+ instrument system onboard the platform RV Neil Armstrong

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/130618
title: Expendable Probe data collected during research cruise AR30-05 using a Sippican MK21 instrument system onboard the platform RV Neil Armstrong

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/130602
title: Fluorometer data collected during research cruise AR30-05 using a WET Labs WETStar instrument system onboard the platform RV Neil Armstrong

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/130611
title: GNSS (Global Navigation Satellite System) data collected during research cruise AR30-05 using a C&C C-Nav 3050 instrument system onboard the platform RV Neil Armstrong

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/130603
title: Gyrocompass data collected during research cruise AR30-05 using a Sperry NAVIGAT X MK 1 instrument system onboard the platform RV Neil Armstrong

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/130617
title: Meteorological Station data collected during research cruise AR30-05 using a Vaisala WXT520 instrument system onboard the platform RV Neil Armstrong

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/130619
title: Multibeam Echosounder data collected during research cruise AR30-05 using a Kongsberg EM122 instrument system onboard the platform RV Neil Armstrong

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/130620
title: Multibeam Echosounder data collected during research cruise AR30-05 using a Kongsberg EM122 instrument system onboard the platform RV Neil Armstrong

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/130609
title: Radiometer data collected during research cruise AR30-05 using a Biospherical QSR-2150 instrument system onboard the platform RV Neil Armstrong

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/130610
title: Radiometer data collected during research cruise AR30-05 using a Eppley RAD instrument system onboard the platform RV Neil Armstrong

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/130608
title: Singlebeam Echosounder data collected during research cruise AR30-05 using a Knudsen 3260 instrument system onboard the platform RV Neil Armstrong

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/130601
title: Speedlog data collected during research cruise AR30-05 using a JRC JLN-550 instrument system onboard the platform RV Neil Armstrong

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/130606
title: SSV (Sound Speed Velocimeter) data collected during research cruise AR30-05 using a AML SmartX P1S2 instrument system onboard the platform RV Neil Armstrong

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/130600
title: Water Temperature data collected during research cruise AR30-05 using a Sea-Bird SBE-48 instrument system onboard the platform RV Neil Armstrong

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/130599
title: TSG (Thermosalinograph) data collected during research cruise AR30-05 using a Sea-Bird SBE-45 instrument system onboard the platform RV Neil Armstrong

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.18462/iir.iccc.2020.293092
title: Novel method for the analysis of clathrates.
DOI: 10.5523/bris.4ji1p911bh6t20mcg6zgwwqwv
title: High Entropy Alloy Magnetism
title: HEA_Magnetism_Data

description: Compton profiles, SQUID magnetometry and X-ray circular magnetic dichroism (XMCD)
DOI: 10.6084/m9.figshare.13072466
title: R0183_20170812a_videos

description: Rat 0183, skilled reaching data collected in Leventhal laboratory by Alexandra Bova
DOI: 10.6084/m9.figshare.13072466.v1
title: R0183_20170812a_videos

description: Rat 0183, skilled reaching data collected in Leventhal laboratory by Alexandra Bova
DOI: 10.5281/zenodo.4075167
title: Datasets for Effective Distributed Representations for Academic Expert Search

description: Dataset for the "Effective Distributed Representations for Academic Expert Search" paper published at the SDP 2020 workshop of the EMNLP conference.
DOI: 10.25502/7xqn-bb55/d
title: Nutrient omission trials cassava root yield data from Nigeria and Tanzania

description: ACAI is a 5 year Bill & Melinda Gates Foundation funded project in 5 countries in Africa (Nigeria and Tanzania) providing tailored agronomic advice to small scale cassava growers in the target countries. The project delivers agronomic solutions to improve cassava root yield and quality and the necessary knowledge base and applications for accessing this knowledge to cassava scaling partners and ultimately farmers in the target countries while instituting the necessary capacity and skills for national system scientists to engage in transformative cassava agronomy.
DOI: 10.18462/iir.iccc.2020.292847
title: Field assessment of the performance of a state-of-the-art CO2 integrated system for supermarket with distributed HVAC terminals in the shopping area.
DOI: 10.5517/ccdc.csd.cc23dx5m
title: CCDC 1948820: Experimental Crystal Structure Determination

description: Related Article: Yong Yan, Elliot J. Carrington, Rémi Pétuya, George F. S. Whitehead, Ajay Verma, Rebecca K. Hylton, Chiu C. Tang, Neil G. Berry, George R. Darling, Matthew S. Dyer, Dmytro Antypov, Alexandros P. Katsoulidis, Matthew J. Rosseinsky|2020|J.Am.Chem.Soc.|142|14903|doi:10.1021/jacs.0c03853
DOI: 10.5517/ccdc.csd.cc23dx6n
title: CCDC 1948821: Experimental Crystal Structure Determination

description: Related Article: Yong Yan, Elliot J. Carrington, Rémi Pétuya, George F. S. Whitehead, Ajay Verma, Rebecca K. Hylton, Chiu C. Tang, Neil G. Berry, George R. Darling, Matthew S. Dyer, Dmytro Antypov, Alexandros P. Katsoulidis, Matthew J. Rosseinsky|2020|J.Am.Chem.Soc.|142|14903|doi:10.1021/jacs.0c03853
DOI: 10.5517/ccdc.csd.cc23dx7p
title: CCDC 1948822: Experimental Crystal Structure Determination

description: Related Article: Yong Yan, Elliot J. Carrington, Rémi Pétuya, George F. S. Whitehead, Ajay Verma, Rebecca K. Hylton, Chiu C. Tang, Neil G. Berry, George R. Darling, Matthew S. Dyer, Dmytro Antypov, Alexandros P. Katsoulidis, Matthew J. Rosseinsky|2020|J.Am.Chem.Soc.|142|14903|doi:10.1021/jacs.0c03853
DOI: 10.5517/ccdc.csd.cc25hrs7
title: CCDC 2011149: Experimental Crystal Structure Determination

description: Related Article: Rodolfo Moreno-Fuquen, María Mercedes Hincapié-Otero, Diana Becerra, Juan-Carlos Castillo, Jaime Portilla, Mario A. Macías|2021|J.Mol.Struct.|1226|129317|doi:10.1016/j.molstruc.2020.129317
DOI: 10.5517/ccdc.csd.cc25hrt8
title: CCDC 2011150: Experimental Crystal Structure Determination

description: Related Article: Rodolfo Moreno-Fuquen, María Mercedes Hincapié-Otero, Diana Becerra, Juan-Carlos Castillo, Jaime Portilla, Mario A. Macías|2021|J.Mol.Struct.|1226|129317|doi:10.1016/j.molstruc.2020.129317
DOI: 10.18462/iir.iccc.2020.292842
title: Cryogenic cold utilization and system integration possibilities for LNG-driven fishing vessels.
DOI: 10.18462/iir.iccc.2020.292828
title: Hydrocarbon Refrigerant for Refrigeration Applications in Indonesia: Performance and Safety Analysis.
DOI: 10.5281/zenodo.4074184
title: The association between tumor mutational burden and prognosis is dependent on treatment context

description: This dataset has been used to analyze the association between high tumour mutational burden and survival in immunotherapy-treated and non–immunotherapy-treated patients with cancer. The dataset contains clinical and genomic data for 10,233 patients with 17 cancer types.
DOI: 10.5281/zenodo.4074183
title: The association between tumor mutational burden and prognosis is dependent on treatment context

description: This dataset has been used to analyze the association between high tumour mutational burden and survival in immunotherapy-treated and non–immunotherapy-treated patients with cancer. The dataset contains clinical and genomic data for 10,233 patients with 17 cancer types.
DOI: 10.18462/iir.iccc.2020.292797
title: Decarbonization of the retail sector in the cold chain as a mean for sustainable cooling.
DOI: 10.6084/m9.figshare.13072775
title: Conhecimento etnobotânico de moradores do Sítio Histórico de Olinda, Patrimônio Natural e Cultural da Humanidade –– Ethnobotanical knowledge of Olinda’s historical site’s inhabitants, Natural and Cultural Heritage of Humanity –– Material Suplementar / Supplementary Material

description: <b>Espécies vegetais conhecidas e utilizadas pelos entrevistados no Sítio Histórico de Olinda (Pernambuco, Brasil), e área peri-urbana dessa cidade.</b>
DOI: 10.17638/datacat.liverpool.ac.uk/1165
title: Single molecule conductance data for "Selective anchoring groups for molecular electronic junctions with ITO electrodes"

description: See README.txt
DOI: 10.21227/a506-h180
title: Naive method

description: First developed method. It is based on inferring the missing monthly consumption in 2017 using a linear model that considers as inputs multiple statistics like the mean, the standard deviaton, or extreme quantiles.
DOI: 10.21227/r1qp-3e94
title: Naive method improved

description: Second developed method. It is an improved version of the naive model which was based on inferring all monthly consumption in 2017 using a linear model that considers as inputs multiple statistics like the mean, the standard deviaton, or extreme quantiles. The difference w.r.t. that one is that now we predict all values using a linear model and not just the missing values.
DOI: 10.26050/wdcc/happi-global-canam4
title: Simulations of HAPPI (Half a degree Additional warming, Prognosis and Projected Impacts) Tier-1 experiments based on the CanAM4 atmospheric model of the Canadian Centre for Climate Modelling and Analysis (CCCma)

description: Project: IPCC Special Report on Global Warming of 1.5 °C - The project embraces the global model output data, relevant for the Special Report on IPCC special report on the impacts of global warming of 1.5 °C above pre-industrial levels and related global greenhouse gas emission pathways (SR1.5) of the Intergovernmental Panel on Climate Change (IPCC: http://www.ipcc.ch), published in 2018. The data was provided by the international HAPPI-MIP initiative (Half a degree Additional warming, Prognosis and Projected Impacts - Model Intercomparison Project: http://www.happimip.org/). Summary: Global HAPPI-MIP protocol data based on the CanAM4 [1] AGCM developed by the Canadian Centre for Climate Modelling and Analysis (CCCma). This CERA experiment includes data of 100 AMIP simulations of the period 2006-2015, 100 AMIP-like simulations of 2106-2115 representing a climate warmer by 1.5°C than under pre-industrial conditions (1861-1880) and 100 AMIP-like simulations of 2106-2115 representing a climate warmer by 2.0°C than under pre-industrial conditions (1861-1880). Reference: [1] https://doi.org/10.1080/07055900.2012.755610
DOI: 10.26050/wdcc/happi-global-cam4-2degree
title: Simulations of HAPPI (Half a degree Additional warming, Prognosis and Projected Impacts) Tier-1 experiments based on the CAM4-2degree atmospheric model and on the CLM4-2degree land model of the National Center for Atmospheric Research - Department of Energy (NCAR-DOE)

description: Project: IPCC Special Report on Global Warming of 1.5 °C - The project embraces the global model output data, relevant for the Special Report on IPCC special report on the impacts of global warming of 1.5 °C above pre-industrial levels and related global greenhouse gas emission pathways (SR1.5) of the Intergovernmental Panel on Climate Change (IPCC: http://www.ipcc.ch), published in 2018. The data was provided by the international HAPPI-MIP initiative (Half a degree Additional warming, Prognosis and Projected Impacts - Model Intercomparison Project: http://www.happimip.org/). Summary: Global HAPPI-MIP protocol data based on the CAM4[1]/CLM4 [2] (CAM4-2degree) AGCM developed by the National Center for Atmospheric Research – Department of Energy (NCAR-DOE). CAM4/CLM4 is part of the CESM 1.0.4 model release [3]. This CERA experiment includes data of 521 AMIP simulations within the period 1979-2016, 501 AMIP-like simulations of 2106-2116 representing a climate warmer by 1.5°C than under pre-industrial conditions (1861-1880) and 501 AMIP-like simulations of 2106-2116 representing a climate warmer by 2.0°C than under pre-industrial conditions (1861-1880). Reference: [1] Neale, R. B., Richter, J. H., Conley, A. J., Park, S., Lauritzen, P. H., Gettelman, A., Williamson, D. L., Rasch, P. J., Vavrus, S. J., Taylor, M. A., Collins, W. D., Zhang, M., and Lin, S.-J.: Description of the NCAR Community Atmosphere Model (CAM4). NCAR Tech. Note NCAR/TN-485+STR, National Center for Atmospheric Research, Boulder, CO, 120 pp., 2011. [2] Oleson, K. W., Lawrence, D. M., Bonan, G. B., Flanner, M. G., Kluzek, E., Lawrence, P. J., Levis, S., Swenson, S. C., Thornton, P. E., Dai, A., Decker, M., Dickinson, R., Feddema, J., Heald, C. L., Hoffman, F., Lamarque, J.-F., Mahowald, N., Niu, G.-Y., Qian, T., Randerson, J., Running, S., Sakaguchi, K., Slater, A., Stockli, R., Wang, A., Yang, Z.-L., Zeng, Xi., and Zeng, Xu.: Technical Description of version 4.0 of the Community Land Model (CLM), NCAR Tech. Note NCAR/TN-478+STR, National Center for Atmospheric Research, Boulder, CO, 257 pp., 2010. [3] http://www.cesm.ucar.edu/models/cesm1.0/tags/index.html#CESM1_0_4