cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.3535/ste-0kq-3gp
title: Acteocina canaliculata (Say, 1826)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/me7-ell-f5c
title: Patella vulgata Linnaeus, 1758

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/83v-qzt-r25
title: Alvania lactea (Michaud, 1830)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/wh7-y80-3cv
title: Chama gryphoides Linnaeus, 1758

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/rbc-kzf-cdp
title: Enoplochiton niger (Barnes, 1824)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/s9w-zll-8kc
title: Graphicomassa ligula (Duclos, 1840)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/dyb-1sc-740
title: Tonicella marmorea (O. Fabricius, 1780)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/jnx-hg0-44g
title: Haminoea navicula (da Costa, 1778)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/8j0-0ml-ex2
title: Tonicia schrammi (Shuttleworth, 1856)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/x1j-2y2-wqf
title: Bassina disjecta (Perry, 1811)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/1h7-709-xyd
title: Benimakia lanceolata (Reeve, 1847)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/v9h-3xe-w8r
title: Fenimorea janetae Bartsch, 1934

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/6ex-a78-11g
title: Williamia gussoni (O. G. Costa, 1829)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/4y8-e6e-f4z
title: Rissoa variabilis (Megerle von Mühlfeld, 1824)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/jyx-q33-2hc
title: Stenochiton pilsbryanus (Bednall, 1897)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/657-0r9-6qj
title: Lyncina carneola (Linnaeus, 1758)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/rt1-0x2-tjw
title: Conus villepinii P. Fischer & Bernardi, 1857

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/aev-q1p-cvr
title: Myadora pulleinei Hedley, 1906

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/ayt-smd-1kc
title: Niso hendersoni Bartsch, 1953

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/lfb-hha-nw9
title: Mytilus edulis Linnaeus, 1758

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/pyh-0gq-qyd
title: Phrontis vibex (Say, 1822)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/ssw-2yb-a8d
title: Malleus malleus (Linnaeus, 1758)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/grs-erj-12a
title: Choromytilus meridionalis (Krauss, 1848)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/j4w-1r8-fhw
title: Aequipecten commutatus (Monterosato, 1875)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/5zb-ay1-ldl
title: Bornia geoffroyi (Payraudeau, 1826)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/q0r-f6r-5sg
title: Bullia pura Melvill, 1885

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/aa7-xm8-3dx
title: Tectarius antonii (R. A. Philippi, 1846)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/es8-w7y-nvd
title: Isanda H. Adams & A. Adams, 1854

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/lwj-b6v-nfq
title: Bullata lilacina (G. B. Sowerby II, 1846)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/rzf-8x3-wd7
title: Murexsul huberti (Radwin & D'Attilio, 1976)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/wlk-81m-wac
title: Phyllonotus margaritensis (Abbott, 1958)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/bjc-csr-e0k
title: Ondina warreni (W. Thompson, 1845)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/xr7-l14-tt4
title: Tonicia atrata (G. B. Sowerby II, 1839)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/mw4-cdv-htg
title: Odostomia J. Fleming, 1813

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/vl4-t2g-8r0
title: Pyrgiscus rufus (R. A. Philippi, 1836)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/e4j-9rg-vte
title: Odostomia J. Fleming, 1813

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/tx1-nr4-a6l
title: Divalucina cumingi (A. Adams & Angas, 1864)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/4jy-eh8-lga
title: Valvata cristata O. F. Müller, 1774

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/gr8-kfp-1cn
title: Myadora brevis (G. B. Sowerby I, 1827)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/ha1-azt-jty
title: Microstagon trigonum (Scacchi, 1835)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/487-y2g-md3
title: Viviparus viviparus (Linnaeus, 1758)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/z3j-d0d-s66
title: Loripes orbiculatus Poli, 1795

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/3q8-61v-98s
title: Epilepton clarkiae (W. Clark, 1852)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/qks-7tv-22j
title: Irus crenatus (Lamarck, 1818)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/q5b-1a1-c4b
title: Incisura Hedley, 1904

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.15468/dl.bs5fn2
title: Occurrence Download

description: A dataset containing 1065269 species occurrences available in GBIF matching the query:
{
 "and" : [
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 "TaxonKey is Fagus sylvatica",
 "Year 1957-2022"
 ]
}

 The dataset includes 1065269 records from 1941 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0000069-250811113504898/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.5286/isis.e.rb2520600
title: Search for magnetic long-range order in a spin-liquid candidate K2Ti2(PO4)3

description: Quantum spin liquids (QSLs), lacking long-range magnetic order (LRO) due to quantum fluctuations, are pursued in frustrated systems. Recent studies highlight 3D trillium lattices, e.g., K₂Ni₂(SO₄)₃, showing dynamic ground states despite weak order. We present K₂Ti₂(PO₄)₃, a langbeinite with Ti³⁺ (S=1/2) on a single trillium lattice—structurally akin to MnSi but localized. Contrary to theory, magnetization shows no LRO down to 0.3 K, with antiferromagnetic correlations (θ ≈ -30 K). AC susceptibility reveals a 0.2 K maximum, while zero-field μSR confirms a dynamic ground state at 30 mK, persisting under 2 T. These findings challenge single-trillium frustration models. We propose neutron diffraction on K₂Ti₂(PO₄)₃ powders (100 mK, WISH) to detect magnetic Bragg peaks or diffuse scattering. Prior work on K₂Ni₂(SO₄)₃ showed WISH’s sensitivity to subtle order (e.g., tripled magnetic cells) despite μSR dynamics. Measurements at 100 mK (~4h) and temperature scans (20 mK steps) will resolve structural/magnetic symmetry. Detecting order would challenge QSL criteria; absence strengthens 3D QSL evidence. This study bridges theory-experiment gaps in quantum magnetism. We request 2 days on WISH (cooldown included) to decode this S=1/2 trillium system’s ground state.
DOI: 10.15468/dl.en8327
title: Occurrence Download

description: A dataset containing 2 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Cyanoliseus patagonus",
 "Country is United Kingdom of Great Britain and Northern Ireland",
 "HasCoordinate is true"
 ]
}

 The dataset includes 2 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0011012-251009101135966/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.25549/inscriptifact-ouc110588327
title: Persepolis Fortification Elamite Text 0208, PF 0208

description: [Text Description:] Administrative text with seal PFS 0178. Aramaic gloss. ❧ [Text or Publication Number Note:] PF 0208 ❧ [Excavation Description:] Found during Oriental Institute's excavations in Spring, 1933, near the northeastern corner of the stone platform of Persepolis, in two small rooms of a bastion in the fortification wall ❧ [Medium:] Clay ❧ [Script Note:] Non-Alphabetic Cuneiform, Aramaic ❧ [Physical Object Description:] Clay tablet with cuneiform text. Seal impressions (PFS 0178) left edge, reverse, upper edge. Aramaic gloss in ink, left edge (two lines), reverse (two lines).
DOI: 10.25549/inscriptifact-ouc110593847
title: Persepolis Fortification Anepigraphic Tablet 0267.102, PFAnep 0267.102

description: [Text Description:] Administrative text with seal PFUTS 0021 ❧ [Text or Publication Number Note:] PFAnep 0267.102, PFUT 0267-102 ❧ [Excavation Description:] Found during Oriental Institute's excavations in Spring, 1933, near the northeastern corner of the stone platform of Persepolis, in two small rooms of a bastion in the fortification wall ❧ [Medium:] Clay ❧ [Script Note:] Non-Text ❧ [Physical Object Description:] Clay tablet with seal impression PFUTS 0021 on obverse. ❧ [Physical Object Note:] Damage on upper edge, reverse, left edge
DOI: 10.25549/jrbm-c91-1738
title: Unjigi, 1---?

description: Kūkai. Unjigi. [Japan: s.l., 1---?]. = 空海. 吽字義. [Japan: s.l., 1---?]. Text in Chinese; with Japanese reading marks. Henjōkongō sen = 遍照金剛撰.
DOI: 10.25549/inscriptifact-ouc110588294
title: Persepolis Fortification Aramaic Text 199, PFAT 199

description: [Text Description:] Administrative text with seals PFATS 0227; PFATS 0228; PFATS 0226s ❧ [Text or Publication Number Note:] PFAT 199, Bowman 199 ❧ [Excavation Description:] Found during Oriental Institute's excavations in Spring, 1933, near the northeastern corner of the stone platform of Persepolis, in two small rooms of a bastion in the fortification wall ❧ [Medium:] Clay ❧ [Script Note:] Aramaic ❧ [Physical Object Description:] Clay tablet with ink inscription. Seal impressions PFATS 0227 on obverse; PFATS 0228 on upper edge; PFATS 0226s on reverse.
DOI: 10.25549/inscriptifact-ouc110593825
title: Persepolis Fortification Elamite Tablet 0894, PF-NN 0894

description: [Text Description:] Administrative text with seals ❧ [Text or Publication Number Note:] PF-NN 0894 ❧ [Excavation Description:] Found during Oriental Institute's excavations in Spring, 1933, near the northeastern corner of the stone platform of Persepolis, in two small rooms of a bastion in the fortification wall ❧ [Medium:] Clay ❧ [Script Note:] Non-Alphabetic Cuneiform, Aramaic ❧ [Physical Object Description:] Clay tablet with cuneiform text.
DOI: 10.25549/jrbm-c91-1747
title: Unjigi, 1---?

description: Kūkai. Unjigi. [Japan: s.l., 1---?]. = 空海. 吽字義. [Japan: s.l., 1---?]. Text in Chinese; with Japanese reading marks. Henjōkongō sen = 遍照金剛撰.
DOI: 10.25549/inscriptifact-ouc110588289
title: Persepolis Fortification Aramaic Text 200, PFAT 200

description: [Text Description:] Administrative text with illegible seal ❧ [Text or Publication Number Note:] PFAT 200, Bowman 200 ❧ [Excavation Description:] Found during Oriental Institute's excavations in Spring, 1933, near the northeastern corner of the stone platform of Persepolis, in two small rooms of a bastion in the fortification wall ❧ [Medium:] Clay ❧ [Script Note:] Aramaic ❧ [Physical Object Description:] Clay tablet with ink inscription. Illegible seal impression on obverse.
DOI: 10.25549/inscriptifact-ouc110593824
title: Persepolis Fortification Elamite Tablet 0894, PF-NN 0894

description: [Text Description:] Administrative text with seals ❧ [Text or Publication Number Note:] PF-NN 0894 ❧ [Excavation Description:] Found during Oriental Institute's excavations in Spring, 1933, near the northeastern corner of the stone platform of Persepolis, in two small rooms of a bastion in the fortification wall ❧ [Medium:] Clay ❧ [Script Note:] Non-Alphabetic Cuneiform, Aramaic ❧ [Physical Object Description:] Clay tablet with cuneiform text.
DOI: 10.25549/jrbm-c91-1705
title: Shōchū rokujō, 1797

description: Shōchū rokujō. Nijōdōri [Kyoto]: Yoshida Shirōuemon, Kansei 9 [1797]. = 掌中六帖. 二条通 [Kyoto]: 吉田四郎右衞門, 寛政9 [1797]. On double leaves, oriental style (fukurotoji).
DOI: 10.25549/inscriptifact-ouc110588288
title: Persepolis Fortification Aramaic Text 199, PFAT 199

description: [Text Description:] Administrative text with seals PFATS 0227; PFATS 0228; PFATS 0226s ❧ [Text or Publication Number Note:] PFAT 199, Bowman 199 ❧ [Excavation Description:] Found during Oriental Institute's excavations in Spring, 1933, near the northeastern corner of the stone platform of Persepolis, in two small rooms of a bastion in the fortification wall ❧ [Medium:] Clay ❧ [Script Note:] Aramaic ❧ [Physical Object Description:] Clay tablet with ink inscription. Seal impressions PFATS 0227 on obverse; PFATS 0228 on upper edge; PFATS 0226s on reverse.
DOI: 10.25549/inscriptifact-ouc110593820
title: Persepolis Fortification Elamite Tablet 0894, PF-NN 0894

description: [Text Description:] Administrative text with seals ❧ [Text or Publication Number Note:] PF-NN 0894 ❧ [Excavation Description:] Found during Oriental Institute's excavations in Spring, 1933, near the northeastern corner of the stone platform of Persepolis, in two small rooms of a bastion in the fortification wall ❧ [Medium:] Clay ❧ [Script Note:] Non-Alphabetic Cuneiform, Aramaic ❧ [Physical Object Description:] Clay tablet with cuneiform text.
DOI: 10.25549/jrbm-c91-811
title: Kongōkai nenju shidai, vol. 1, [s.d.]

description: Kongōkai nenju shidai, volume 1. [Japan: s.l., 1---?]. = 金剛界念誦次第, 一 文化. [Japan: s.l., 1---?]. Manuscript. In wooden box with volume 2.
DOI: 10.25549/inscriptifact-ouc110588286
title: Persepolis Fortification Aramaic Text 200, PFAT 200

description: [Text Description:] Administrative text with illegible seal ❧ [Text or Publication Number Note:] PFAT 200, Bowman 200 ❧ [Excavation Description:] Found during Oriental Institute's excavations in Spring, 1933, near the northeastern corner of the stone platform of Persepolis, in two small rooms of a bastion in the fortification wall ❧ [Medium:] Clay ❧ [Script Note:] Aramaic ❧ [Physical Object Description:] Clay tablet with ink inscription. Illegible seal impression on obverse.
DOI: 10.25549/inscriptifact-ouc110593808
title: Persepolis Fortification Elamite Tablet 0894, PF-NN 0894

description: [Text Description:] Administrative text with seals ❧ [Text or Publication Number Note:] PF-NN 0894 ❧ [Excavation Description:] Found during Oriental Institute's excavations in Spring, 1933, near the northeastern corner of the stone platform of Persepolis, in two small rooms of a bastion in the fortification wall ❧ [Medium:] Clay ❧ [Script Note:] Non-Alphabetic Cuneiform, Aramaic ❧ [Physical Object Description:] Clay tablet with cuneiform text.
DOI: 10.25549/jrbm-c91-1476
title: Yakusha nigao hayageiko, 1817

description: Ichiyōsai Toyokuni Utagawa. Yakusha nigao hayageiko. Tōto [Edo]: Tsuruya Kiemon jōshi, [1817]. = 歌川豊国. 役者似顔早稽古. 東都 [江戶]: 鶴屋喜右衞門上梓, [1817]. Title from postscript. On double leaves, traditional East Asian binding style (fukurotoji). Preface by Jippensha Ikku, dated Bunka 14 [1817]. Postscript by Jippensha monjin Gohensha Hanku. Preface by 十返舎一九, dated 文化 14 [1817]. Postscript by 十返舎門人五返舎半九.
DOI: 10.25549/inscriptifact-ouc110593766
title: Persepolis Fortification Elamite Tablet 0894, PF-NN 0894

description: [Text Description:] Administrative text with seals ❧ [Text or Publication Number Note:] PF-NN 0894 ❧ [Excavation Description:] Found during Oriental Institute's excavations in Spring, 1933, near the northeastern corner of the stone platform of Persepolis, in two small rooms of a bastion in the fortification wall ❧ [Medium:] Clay ❧ [Script Note:] Non-Alphabetic Cuneiform, Aramaic ❧ [Physical Object Description:] Clay tablet with cuneiform text.
DOI: 10.25549/inscriptifact-ouc110593807
title: Persepolis Fortification Elamite Tablet 0894, PF-NN 0894

description: [Text Description:] Administrative text with seals ❧ [Text or Publication Number Note:] PF-NN 0894 ❧ [Excavation Description:] Found during Oriental Institute's excavations in Spring, 1933, near the northeastern corner of the stone platform of Persepolis, in two small rooms of a bastion in the fortification wall ❧ [Medium:] Clay ❧ [Script Note:] Non-Alphabetic Cuneiform, Aramaic ❧ [Physical Object Description:] Clay tablet with cuneiform text.
DOI: 10.25549/jrbm-c91-1480
title: Yakusha nigao hayageiko, 1817

description: Ichiyōsai Toyokuni Utagawa. Yakusha nigao hayageiko. Tōto [Edo]: Tsuruya Kiemon jōshi, [1817]. = 歌川豊国. 役者似顔早稽古. 東都 [江戶]: 鶴屋喜右衞門上梓, [1817]. Title from postscript. On double leaves, traditional East Asian binding style (fukurotoji). Preface by Jippensha Ikku, dated Bunka 14 [1817]. Postscript by Jippensha monjin Gohensha Hanku. Preface by 十返舎一九, dated 文化 14 [1817]. Postscript by 十返舎門人五返舎半九.
DOI: 10.25549/inscriptifact-ouc110593765
title: Persepolis Fortification Elamite Tablet 0894, PF-NN 0894

description: [Text Description:] Administrative text with seals ❧ [Text or Publication Number Note:] PF-NN 0894 ❧ [Excavation Description:] Found during Oriental Institute's excavations in Spring, 1933, near the northeastern corner of the stone platform of Persepolis, in two small rooms of a bastion in the fortification wall ❧ [Medium:] Clay ❧ [Script Note:] Non-Alphabetic Cuneiform, Aramaic ❧ [Physical Object Description:] Clay tablet with cuneiform text.
DOI: 10.25549/inscriptifact-ouc110593798
title: Persepolis Fortification Elamite Tablet 0894, PF-NN 0894

description: [Text Description:] Administrative text with seals ❧ [Text or Publication Number Note:] PF-NN 0894 ❧ [Excavation Description:] Found during Oriental Institute's excavations in Spring, 1933, near the northeastern corner of the stone platform of Persepolis, in two small rooms of a bastion in the fortification wall ❧ [Medium:] Clay ❧ [Script Note:] Non-Alphabetic Cuneiform, Aramaic ❧ [Physical Object Description:] Clay tablet with cuneiform text.
DOI: 10.25549/jrbm-c91-1740
title: Unjigi, 1---?

description: Kūkai. Unjigi. [Japan: s.l., 1---?]. = 空海. 吽字義. [Japan: s.l., 1---?]. Text in Chinese; with Japanese reading marks. Henjōkongō sen = 遍照金剛撰.
DOI: 10.5281/zenodo.15311191
title: DMP: Khush Libaas – AI Powered Fashion Recommendation System

description: This DMP outlines the creation, FAIR documentation, and sharing of the Khush Libaas – Fashion Recommendation Dataset. The project involves synthetic data creation, machine learning modeling, and metadata curation. All outputs are openly accessible under CC BY 4.0 via TUWRD and GitHub. Developed as coursework for the FAIR Data Science module at TU Wien.

GitHub Repository: https://github.com/MohsinKhalid08/Khush-Libaas-FAIRORCID: https://orcid.org/0009-0000-9775-1879
DOI: 10.5281/zenodo.15311192
title: DMP: Khush Libaas – AI Powered Fashion Recommendation System

description: This DMP outlines the creation, FAIR documentation, and sharing of the Khush Libaas – Fashion Recommendation Dataset. The project involves synthetic data creation, machine learning modeling, and metadata curation. All outputs are openly accessible under CC BY 4.0 via TUWRD and GitHub. Developed as coursework for the FAIR Data Science module at TU Wien.

GitHub Repository: https://github.com/MohsinKhalid08/Khush-Libaas-FAIRORCID: https://orcid.org/0009-0000-9775-1879
DOI: 10.6084/m9.figshare.28941812
title: LC-MS data for "Genetically encoded fluorescent reporter for polyamines"

description: Polyamines are abundant and evolutionarily conserved metabolites that are essential for life. Dietary polyamine supplementation extends life-span and health-span. Dysregulation of polyamine homeostasis is linked to Parkinson's disease and cancer, driving interest in therapeutically targeting this pathway. However, measuring cellular polyamine levels, which vary across cell types and states, remains challenging. We introduce a first-in-class genetically encoded polyamine reporter for real-time measurement of polyamine concentrations in single living cells. This reporter utilizes the polyamine-responsive ribosomal frameshift motif from the OAZ1 gene. We demonstrate broad applicability of this approach and reveal dynamic changes in polyamine levels in response to genetic and pharmacological perturbations. Using this reporter, we conducted a genome-wide CRISPR screen and uncovered an unexpected link between mitochondrial respiration and polyamine import, which are both risk factors for Parkinson's disease. By offering a new lens to examine polyamine biology, this reporter may advance our understanding of these ubiquitous metabolites and accelerate therapy development.
DOI: 10.6084/m9.figshare.28941812.v1
title: LC-MS data for "Genetically encoded fluorescent reporter for polyamines"

description: Polyamines are abundant and evolutionarily conserved metabolites that are essential for life. Dietary polyamine supplementation extends life-span and health-span. Dysregulation of polyamine homeostasis is linked to Parkinson's disease and cancer, driving interest in therapeutically targeting this pathway. However, measuring cellular polyamine levels, which vary across cell types and states, remains challenging. We introduce a first-in-class genetically encoded polyamine reporter for real-time measurement of polyamine concentrations in single living cells. This reporter utilizes the polyamine-responsive ribosomal frameshift motif from the OAZ1 gene. We demonstrate broad applicability of this approach and reveal dynamic changes in polyamine levels in response to genetic and pharmacological perturbations. Using this reporter, we conducted a genome-wide CRISPR screen and uncovered an unexpected link between mitochondrial respiration and polyamine import, which are both risk factors for Parkinson's disease. By offering a new lens to examine polyamine biology, this reporter may advance our understanding of these ubiquitous metabolites and accelerate therapy development.