cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.7649207
title: Pentadecanal inspired molecules as new anti-biofilm agents against <i>Staphylococcus epidermidis</i>

description: <i>Staphylococcus epidermidis</i>, a harmless human skin colonizer, is a significant nosocomial pathogen in predisposed hosts because of its capability to form a biofilm on indwelling medical devices. In a recent paper, the purification and identification of the pentadecanal produced by the Antarctic bacterium <i>Pseudoalteromonas haloplanktis</i> TAC125, able to impair <i>S. epidermidis</i> biofilm formation, were reported. Here the authors report on the chemical synthesis of pentadecanal derivatives, their anti-biofilm activity on <i>S. epidermidis</i>, and their action in combination with antibiotics. The results clearly indicate that the pentadecanal derivatives were able to prevent, to a different extent, biofilm formation and that pentadecanoic acid positively modulated the antimicrobial activity of the vancomycin. The cytotoxicity of these new anti-biofilm molecules was tested on two different immortalized eukaryotic cell lines in view of their potential applications.
DOI: 10.6084/m9.figshare.7649207.v1
title: Pentadecanal inspired molecules as new anti-biofilm agents against <i>Staphylococcus epidermidis</i>

description: <i>Staphylococcus epidermidis</i>, a harmless human skin colonizer, is a significant nosocomial pathogen in predisposed hosts because of its capability to form a biofilm on indwelling medical devices. In a recent paper, the purification and identification of the pentadecanal produced by the Antarctic bacterium <i>Pseudoalteromonas haloplanktis</i> TAC125, able to impair <i>S. epidermidis</i> biofilm formation, were reported. Here the authors report on the chemical synthesis of pentadecanal derivatives, their anti-biofilm activity on <i>S. epidermidis</i>, and their action in combination with antibiotics. The results clearly indicate that the pentadecanal derivatives were able to prevent, to a different extent, biofilm formation and that pentadecanoic acid positively modulated the antimicrobial activity of the vancomycin. The cytotoxicity of these new anti-biofilm molecules was tested on two different immortalized eukaryotic cell lines in view of their potential applications.
DOI: 10.6084/m9.figshare.7649216.v1
title: Remembering with a Friend or a Stranger: Comparing Acquainted and Unacquainted Pairs in Collaborative Eyewitness Interviews

description: Previous findings show that collaborative interviews with pairs of eyewitnesses can result in more accurate testimony than individual interviews, and that partners remember more together if they acknowledge, repeat, rephrase and elaborate upon each other’s contributions. In the present study, we investigated whether these findings differ for pairs of acquainted and unacquainted partners, respectively. Participants viewed a violent movie in the cinema and took part in three eyewitness interviews approximately five days later. The first and the last interview were always individual. The second interview was individual in the nominal condition (<i>N </i>= 22 pairs), collaborative with a known partner in the acquainted condition (<i>N </i>= 21 pairs), or collaborative with a stranger in the unacquainted condition (<i>N </i>= 20 pairs). We replicated benefits of collaborative eyewitness interviews, in terms of error pruning as well as delayed cross-cuing. However, we found no significant differences between acquainted and unacquainted pairs, neither in recall performance nor in retrieval strategies during the collaborative interview. Regardless of acquaintance, pairs who listened to and elaborated upon each other’s contributions during the collaborative interview, remembered more together. The findings are evaluated within the theoretical framework of transactive memory. Practical implications for investigative interviewers are discussed.
DOI: 10.6084/m9.figshare.7649201.v1
title: <i>Aeromonas hydrophila</i> biofilm, exoprotease, and quorum sensing responses to co-cultivation with diverse foodborne pathogens and food spoilage bacteria on crab surfaces

description: The effects of dual species interactions on biofilm formation by <i>Aeromonas hydrophila</i> in the presence of <i>Pseudomonas aeruginosa</i>, <i>Pseudomonas fluorescens</i>, <i>Pectobacterium carotovorum</i>, <i>Salmonella</i> Typhimurium, and <i>Listeria monocytogenes</i> were examined. High-performance liquid chromatography and liquid-chromatography-mass spectrometry were performed to identify <i>N</i>-acyl homoserine lactone (AHL) molecules secreted by monocultures and dual cultures grown in crab broth. Field emission scanning electron microscopy was performed to observe attachment and biofilm formation. <i>P. aeruginosa</i> and <i>P. fluorescens</i> inhibited biofilm formation by <i>A. hydrophila</i> on the crab surface, without affecting their own biofilm-forming abilities. Dual biofilms of <i>S.</i> Typhimurium, <i>L. monocytogenes</i>, or <i>P. carotovorum</i> did not affect <i>A. hydrophila</i> biofilm formation. Exoprotease, AHL, and AI-2 levels were significantly reduced in dual cultures of <i>P. aeruginosa</i> and <i>P. fluorescens</i> with <i>A. hydrophila</i>, supporting the relationship between quorum sensing and biofilm formation. Dual-species biofilms were studied in their natural environment and in the laboratory.
DOI: 10.7284/110474
title: Singlebeam Echosounder data collected during research cruise EN473 using a Knudsen 320B/R instrument system onboard the platform RV Endeavor

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7649192
title: Remembering with a Friend or a Stranger - couple data.sav

description: Previous findings show that collaborative interviews with pairs of eyewitnesses can result in more accurate testimony than individual interviews, and that partners remember more together if they acknowledge, repeat, rephrase and elaborate upon each other’s contributions. In the present study, we investigated whether these findings differ for pairs of acquainted and unacquainted partners, respectively. Participants viewed a violent movie in the cinema and took part in three eyewitness interviews approximately five days later. The first and the last interview were always individual. The second interview was individual in the nominal condition (<i>N </i>= 22 pairs), collaborative with a known partner in the acquainted condition (<i>N </i>= 21 pairs), or collaborative with a stranger in the unacquainted condition (<i>N </i>= 20 pairs). We replicated benefits of collaborative eyewitness interviews, in terms of error pruning as well as delayed cross-cuing. However, we found no significant differences between acquainted and unacquainted pairs, neither in recall performance nor in retrieval strategies during the collaborative interview. Regardless of acquaintance, pairs who listened to and elaborated upon each other’s contributions during the collaborative interview, remembered more together. The findings are evaluated within the theoretical framework of transactive memory. Practical implications for investigative interviewers are discussed.
DOI: 10.6084/m9.figshare.7649198
title: Antihypertensive drugs and prostate cancer risk in a Finnish population-based cohort

description: <b>Background:</b> The etiology of prostate cancer (PCa) involves environmental and genetic factors. Understanding the role of medication use on PCa risk may clarify the pathophysiological changes and mechanisms in development of cancer. <b>Methods:</b> This study investigated PCa risk in relation to overall use of anti-hypertensive drugs and those with specific mechanisms of action. The study cohort (78,615 men) was linked to the prescription database to obtain information on medication use during 20-year follow-up. Information was obtained on PCa diagnoses, causes of deaths, and for a sub-set on B.M.I. and use of non-prescription drugs. Time-dependent drug use variables hazard ratios (HR) with 95% confidence intervals (CI) were calculated using Cox regression analyses. <b>Results:</b> Use of antihypertensive drugs slightly increased PCa risk (HR = 1.16, 95% CI = 1.11–1.22). The risk increase was clearest for metastatic PCa (HR = 1.36, 95% CI = 1.14–1.62). ACE inhibitors, beta-blockers, and diuretics were all separately associated with a small excess risk (HR = 1.10, 95% CI = 1.01–1.19, HR = 1.14, 95% CI = 1.06–1.21, and HR = 1.16, 95% CI = 1.07–1.27, respectively). None of the other groups showed a clear association with PCa risk. <b>Conclusions:</b> The use of antihypertensive drugs was associated with increased prostate cancer risk. Similar risk association for multiple drug groups suggests that the findings may not reflect a direct medication effect, but may be due to underlying hypertension.
DOI: 10.6084/m9.figshare.7649192.v1
title: Remembering with a Friend or a Stranger - couple data.sav

description: Previous findings show that collaborative interviews with pairs of eyewitnesses can result in more accurate testimony than individual interviews, and that partners remember more together if they acknowledge, repeat, rephrase and elaborate upon each other’s contributions. In the present study, we investigated whether these findings differ for pairs of acquainted and unacquainted partners, respectively. Participants viewed a violent movie in the cinema and took part in three eyewitness interviews approximately five days later. The first and the last interview were always individual. The second interview was individual in the nominal condition (<i>N </i>= 22 pairs), collaborative with a known partner in the acquainted condition (<i>N </i>= 21 pairs), or collaborative with a stranger in the unacquainted condition (<i>N </i>= 20 pairs). We replicated benefits of collaborative eyewitness interviews, in terms of error pruning as well as delayed cross-cuing. However, we found no significant differences between acquainted and unacquainted pairs, neither in recall performance nor in retrieval strategies during the collaborative interview. Regardless of acquaintance, pairs who listened to and elaborated upon each other’s contributions during the collaborative interview, remembered more together. The findings are evaluated within the theoretical framework of transactive memory. Practical implications for investigative interviewers are discussed.
DOI: 10.6084/m9.figshare.7649198.v1
title: Antihypertensive drugs and prostate cancer risk in a Finnish population-based cohort

description: <b>Background:</b> The etiology of prostate cancer (PCa) involves environmental and genetic factors. Understanding the role of medication use on PCa risk may clarify the pathophysiological changes and mechanisms in development of cancer. <b>Methods:</b> This study investigated PCa risk in relation to overall use of anti-hypertensive drugs and those with specific mechanisms of action. The study cohort (78,615 men) was linked to the prescription database to obtain information on medication use during 20-year follow-up. Information was obtained on PCa diagnoses, causes of deaths, and for a sub-set on B.M.I. and use of non-prescription drugs. Time-dependent drug use variables hazard ratios (HR) with 95% confidence intervals (CI) were calculated using Cox regression analyses. <b>Results:</b> Use of antihypertensive drugs slightly increased PCa risk (HR = 1.16, 95% CI = 1.11–1.22). The risk increase was clearest for metastatic PCa (HR = 1.36, 95% CI = 1.14–1.62). ACE inhibitors, beta-blockers, and diuretics were all separately associated with a small excess risk (HR = 1.10, 95% CI = 1.01–1.19, HR = 1.14, 95% CI = 1.06–1.21, and HR = 1.16, 95% CI = 1.07–1.27, respectively). None of the other groups showed a clear association with PCa risk. <b>Conclusions:</b> The use of antihypertensive drugs was associated with increased prostate cancer risk. Similar risk association for multiple drug groups suggests that the findings may not reflect a direct medication effect, but may be due to underlying hypertension.
DOI: 10.7284/110475
title: Singlebeam Echosounder data collected during research cruise EN473 using a Knudsen 3260 instrument system onboard the platform RV Endeavor

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7649180
title: The radiological and clinical follow-up of osteonecrosis in cancer patients

description: <b>Background:</b> In patients with cancer, osteonecrosis (ON) lesions can affect multiple sites throughout the skeleton, including the long and short bones and the joints. The aims of this study were to explore the natural course of ON in patients treated for cancer by using radiological classification suitable for multisite ON lesions and to assess correlations between the ON grade and surgical procedures. <b>Material and methods:</b> Data were retrieved from hospital databases on 233 ON lesions in 54 patients (aged 2–73 years at cancer diagnosis; mean age: 25 years). ONs were graded according to the Niinimäki classification, based on magnetic resonance images. Medical records were reviewed to identify surgical procedures. <b>Results:</b> A total of 14 different ON sites were detected; the hip was the most common site (<i>n</i> = 51), followed by the femur (<i>n</i> = 45), tibia (<i>n</i> = 41) and knee (<i>n</i> = 37). Among the 233 ON lesions, 78.1% did not require surgical procedures. The remaining lesions required total joint arthroplasty (TJA; 40/233, 17.2%), core decompression (3.4%) and arthroscopy (1.3%). Most TJAs (33/40, 82.5%) were performed on the hip. ONs of the knee required TJAs only once; grade 3 knee ONs frequently healed (58%, 11/19). None of the diaphyseal or metaphyseal (grade 1–2) ONs of the long bones required surgery, and no fractures of those bones were identified. <b>Conclusions:</b> In conclusion, the natural history of ONs varied by the grade and site. Based on our findings, we would not recommend routine radiological follow-ups for grades 1–2 ON lesions that do not affect the joints, because the clinical consequences of those lesions appear to be minimal, although pain relief would be warranted. In contrast, joint deformations (grade 5) require surgery; therefore, intervention studies should focus on grades 3–4 ON lesions.
DOI: 10.7284/108614
title: Speedlog data collected during research cruise EN473 using a EDO MRQ-4015D instrument system onboard the platform RV Endeavor

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.5517/ccdc.csd.cc24pzjc
title: CCDC 1987333: Experimental Crystal Structure Determination

description: Related Article: Xiao Ou, Xizhen Li, Haowei Rong, Lian Yu, Ming Lu|2020|Chem.Commun.|56|9950|doi:10.1039/D0CC03157G
DOI: 10.6084/m9.figshare.7649180.v1
title: The radiological and clinical follow-up of osteonecrosis in cancer patients

description: <b>Background:</b> In patients with cancer, osteonecrosis (ON) lesions can affect multiple sites throughout the skeleton, including the long and short bones and the joints. The aims of this study were to explore the natural course of ON in patients treated for cancer by using radiological classification suitable for multisite ON lesions and to assess correlations between the ON grade and surgical procedures. <b>Material and methods:</b> Data were retrieved from hospital databases on 233 ON lesions in 54 patients (aged 2–73 years at cancer diagnosis; mean age: 25 years). ONs were graded according to the Niinimäki classification, based on magnetic resonance images. Medical records were reviewed to identify surgical procedures. <b>Results:</b> A total of 14 different ON sites were detected; the hip was the most common site (<i>n</i> = 51), followed by the femur (<i>n</i> = 45), tibia (<i>n</i> = 41) and knee (<i>n</i> = 37). Among the 233 ON lesions, 78.1% did not require surgical procedures. The remaining lesions required total joint arthroplasty (TJA; 40/233, 17.2%), core decompression (3.4%) and arthroscopy (1.3%). Most TJAs (33/40, 82.5%) were performed on the hip. ONs of the knee required TJAs only once; grade 3 knee ONs frequently healed (58%, 11/19). None of the diaphyseal or metaphyseal (grade 1–2) ONs of the long bones required surgery, and no fractures of those bones were identified. <b>Conclusions:</b> In conclusion, the natural history of ONs varied by the grade and site. Based on our findings, we would not recommend routine radiological follow-ups for grades 1–2 ON lesions that do not affect the joints, because the clinical consequences of those lesions appear to be minimal, although pain relief would be warranted. In contrast, joint deformations (grade 5) require surgery; therefore, intervention studies should focus on grades 3–4 ON lesions.
DOI: 10.7284/108613
title: TSG (Thermosalinograph) data collected during research cruise EN473 using a Sea-Bird SBE-45 instrument system onboard the platform RV Endeavor

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/108615
title: TSG (Thermosalinograph) data collected during research cruise EN473 using a Sea-Bird SBE-21 instrument system onboard the platform RV Endeavor

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/107304
title: Winch data collected during research cruise EN473 using a Markey DUSH-5 instrument system onboard the platform RV Endeavor

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7649078
title: Charge balance modeling

description: Uses charge balance to find equilibrium conditions with correction for ionic strength using Davies' equation
DOI: 10.7284/107226
title: Multiplexed data collected during research cruise EN474 using a Hawaii UHDAS instrument system onboard the platform RV Endeavor
DOI: 10.6084/m9.figshare.7649078.v1
title: Charge balance modeling

description: Uses charge balance to find equilibrium conditions with correction for ionic strength using Davies' equation
DOI: 10.7284/103239
title: GNSS (Global Navigation Satellite System) data collected during research cruise EN474 using a Northstar 952 instrument system onboard the platform RV Endeavor

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7649054
title: Supplementary Material for: Postoperative Acute Kidney Injury: Focus on Renal Recovery Definitions, Kidney Disease Progression and Survival

description: <b><i>Background:</i></b> The aim of this study was to examine different definitions of renal recovery following postoperative acute kidney injury (AKI) and how these definitions associate with survival and the development and progression of chronic kidney disease (CKD). <b><i>Methods:</i></b> This was a retrospective study of all patients who underwent abdominal, cardiothoracic, vascular, or orthopedic surgery at a single university hospital between 1998 and 2015. Recovery of renal function following postoperative AKI was assessed comparing 4 different definitions: serum creatinine (SCr) (i) &lt; 1.1 × baseline, (ii) 1.1–1.25 × baseline, (iii) 1.25–1.5 × baseline, and (iv) &gt; 1.5 × baseline. One-year survival and the development or progression of CKD within 5 years was compared with a propensity score-matched control groups. <b><i>Results:</i></b> In total, 2,520 AKI patients were evaluated for renal recovery. Risk of incident and progressive CKD within 5 years was significantly increased if patients did not achieve a reduction in SCr to p &lt; 0.001). <b><i>Conclusions:</i></b> These findings should be considered when a consensus definition of renal recovery after AKI is established.
DOI: 10.6084/m9.figshare.7649057
title: Intrinsically disordered regions mediate macromolecular assembly of the Slit diaphragm proteins associated with Nephrotic syndrome

description: The glomerular filtration barrier (GFB) of the kidney plays an instrumental role in preventing the excretion of large molecules and ensuring the formation of ultra-filtrated urine. Podocytes are essential components of GFB that provide epithelial coverage to the fine glomerular capillaries. Slit-diaphragm (SD) that forms the sole contact between adjacent foot-processes of the podocytes consists of multimeric protein assemblies. SD serves as a molecular sieve and confers size and charge-selective barrier. Nephrin, podocin, TRPC6, and CD2AP are some of the key proteins that constitute the SD. Mutations in these proteins are implicated in nephrotic syndrome and congenital nephropathies which are characterised by heavy proteinuria. The mechanism of how mutations in these proteins predispose to proteinuria is not known. Furthermore, the structural details of proteins that constitute SD are largely unknown. In this study, we built models for nephrin, CD2AP, podocin, and TRPC6 followed by docking and molecular dynamics simulations of the complex of these proteins. We speculate that the interfacial residues of SD proteins form a macromolecular complex through intrinsically disordered regions thereby conferring architectural stability to the SD, which is critical for glomerular permselectivity.
DOI: 10.5517/ccdc.csd.cc25l1zt
title: CCDC 2013356: Experimental Crystal Structure Determination

description: Related Article: Ahmed M. H. Abudken, Eric G. Hope, Kuldip Singh, Alison M. Stuart|2020|Org.Biomol.Chem.|18|6140|doi:10.1039/D0OB01401J
DOI: 10.7284/107307
title: GNSS (Global Navigation Satellite System) data collected during research cruise EN474 using a Furuno GP-90D instrument system onboard the platform RV Endeavor
DOI: 10.5517/ccdc.csd.cc25l20w
title: CCDC 2013357: Experimental Crystal Structure Determination

description: Related Article: Ahmed M. H. Abudken, Eric G. Hope, Kuldip Singh, Alison M. Stuart|2020|Org.Biomol.Chem.|18|6140|doi:10.1039/D0OB01401J
DOI: 10.6084/m9.figshare.7649048
title: Supplementary Material for: A Placebo-Controlled, Randomized Trial of Enarodustat in Patients with Chronic Kidney Disease Followed by Long-Term Trial

description: <b><i>Background:</i></b> Enarodustat (JTZ-951) is an oral hypoxia-inducible factor prolyl hydroxylase inhibitor that mimics adaptive responses to hypoxic conditions and may provide a new therapeutic approach for managing anemia in patients with chronic kidney disease (CKD). We evaluated the efficacy, safety, and maintenance dose of enarodustat in anemic patients with CKD not on dialysis. <b><i>Methods:</i></b> Erythropoiesis-stimulating agent (ESA) naïve patients (correction group) and patients on a stable dose of ESA (conversion group) were randomized to receive 2, 4, or 6 mg of enarodustat or placebo once daily for 6 weeks in a double-blind manner (Period 1) followed by 24 weeks of open enarodustat treatment to maintain their hemoglobin (Hb) levels within a target range of 10.0–12.0 g/dL in reference to a dose adjustment algorithm (Period 2). <b><i>Results:</i></b> In the correction group, Hb level increase rate per week increased in a dose-response manner. The proportion of subjects in the conversion group who maintained Hb levels within ± 1.0 g/dL of baseline did not differ between each enarodustat arm and placebo arm during Period 1. Over 70% of subjects in both groups maintained Hb levels within the target range at the end of treatment in Period 2. The mean prescribed doses were 3.58 and 3.74 mg/day in the correction group and the conversion group, respectively. Enarodustat was associated with decreases in hepcidin and ferritin and increased total iron-binding capacity and was generally well tolerated. <b><i>Conclusions:</i></b> Enarodustat corrects and maintains Hb levels in anemic patients with CKD not on dialysis.