cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.22214442.v1
title: What changed between the peak and plateau periods of the first COVID-19 pandemic wave? A multicentric Portuguese cohort study in intensive care

description: ABSTRACT Objective: To analyze and compare COVID-19 patient characteristics, clinical management and outcomes between the peak and plateau periods of the first pandemic wave in Portugal. Methods: This was a multicentric ambispective cohort study including consecutive severe COVID-19 patients between March and August 2020 from 16 Portuguese intensive care units. The peak and plateau periods, respectively, weeks 10 - 16 and 17 - 34, were defined. Results: Five hundred forty-one adult patients with a median age of 65 [57 - 74] years, mostly male (71.2%), were included. There were no significant differences in median age (p = 0.3), Simplified Acute Physiology Score II (40 versus 39; p = 0.8), partial arterial oxygen pressure/fraction of inspired oxygen ratio (139 versus 136; p = 0.6), antibiotic therapy (57% versus 64%; p = 0.2) at admission, or 28-day mortality (24.4% versus 22.8%; p = 0.7) between the peak and plateau periods. During the peak period, patients had fewer comorbidities (1 [0 - 3] versus 2 [0 - 5]; p = 0.002) and presented a higher use of vasopressors (47% versus 36%; p &lt; 0.001) and invasive mechanical ventilation (58.1 versus 49.2%; p &lt; 0.001) at admission, prone positioning (45% versus 36%; p = 0.04), and hydroxychloroquine (59% versus 10%; p &lt; 0.001) and lopinavir/ritonavir (41% versus 10%; p &lt; 0.001) prescriptions. However, a greater use of high-flow nasal cannulas (5% versus 16%, p &lt; 0.001) on admission, remdesivir (0.3% versus 15%; p &lt; 0.001) and corticosteroid (29% versus 52%, p &lt; 0.001) therapy, and a shorter ICU length of stay (12 days versus 8, p &lt; 0.001) were observed during the plateau. Conclusion: There were significant changes in patient comorbidities, intensive care unit therapies and length of stay between the peak and plateau periods of the first COVID-19 wave.
DOI: 10.6084/m9.figshare.22214444
title: THE POTENTIAL OF NATURAL XANTHONE α-MANGOSTIN IN THE DEVELOPMENT OF NOVEL ANTIINFECTIVE AGENTS: A REVIEW

description: The mangosteen (Garcinia mangostana, Linn.) is a tropical fruit cultivated in the tropical forests of Southeast Asian countries. It is recognized as the queen of fruits due to its unique color, aroma, and flavor. It has been used for centuries in Southeastern Asian traditional medicine for the treatment of various diseases. Many functional molecules with high medicinal value are obtained from the pericarp of mangosteen fruit, whose major constituent is xanthone α-mangostin. Several studies have been carried out over the last decades to further investigate and understand the pharmacological properties associated with the plant and its main chemical constituents, belonging to the class of xanthones. In addition, numerous in vitro and in vivo studies related to mangosteen have been published, indicating its importance and its potential application in medicinal chemistry. Prenylated xanthones, which include α-mangostin, are secondary metabolites particularly common in plants belonging to the Clusiaceae family. These substances have been intensively investigated for their potential as biologically active agents. This article describes a critical analysis of published data related to the properties of α-mangostin, aiming to provide a more detailed view of its potential as a chemotherapeutic agent for the prevention and treatment of infectious diseases.
DOI: 10.6084/m9.figshare.22214444.v1
title: THE POTENTIAL OF NATURAL XANTHONE α-MANGOSTIN IN THE DEVELOPMENT OF NOVEL ANTIINFECTIVE AGENTS: A REVIEW

description: The mangosteen (Garcinia mangostana, Linn.) is a tropical fruit cultivated in the tropical forests of Southeast Asian countries. It is recognized as the queen of fruits due to its unique color, aroma, and flavor. It has been used for centuries in Southeastern Asian traditional medicine for the treatment of various diseases. Many functional molecules with high medicinal value are obtained from the pericarp of mangosteen fruit, whose major constituent is xanthone α-mangostin. Several studies have been carried out over the last decades to further investigate and understand the pharmacological properties associated with the plant and its main chemical constituents, belonging to the class of xanthones. In addition, numerous in vitro and in vivo studies related to mangosteen have been published, indicating its importance and its potential application in medicinal chemistry. Prenylated xanthones, which include α-mangostin, are secondary metabolites particularly common in plants belonging to the Clusiaceae family. These substances have been intensively investigated for their potential as biologically active agents. This article describes a critical analysis of published data related to the properties of α-mangostin, aiming to provide a more detailed view of its potential as a chemotherapeutic agent for the prevention and treatment of infectious diseases.
DOI: 10.6084/m9.figshare.22214447
title: Strategies for the management and prevention of withdrawal syndrome in critically ill pediatric patients: a systematic review

description: ABSTRACT Objective: To verify strategies for the prevention and treatment of abstinence syndrome in a pediatric intensive care unit. Methods: This is a systematic review in the PubMed database®, Lilacs, Embase, Web of Science, Cochrane, Cinahl, Cochrane Database Systematic Review and CENTRAL. A three-step search strategy was used for this review, and the protocol was approved in PROSPERO (CRD42021274670). Results: Twelve articles were included in the analysis. There was great heterogeneity among the studies included, especially regarding the therapeutic regimens used for sedation and analgesia. Midazolam doses ranged from 0.05mg/kg/hour to 0.3mg/kg/hour. Morphine also varied considerably, from 10mcg/kg/hour to 30mcg/kg/hour, between studies. Among the 12 selected studies, the most commonly used scale for the identification of withdrawal symptoms was the Sophia Observational Withdrawal Symptoms Scale. In three studies, there was a statistically significant difference in the prevention and management of the withdrawal syndrome due to the implementation of different protocols (p &lt; 0.01 and p &lt; 0.001). Conclusion: There was great variation in the sedoanalgesia regimen used by the studies and the method of weaning and evaluation of withdrawal syndrome. More studies are needed to provide more robust evidence about the most appropriate treatment for the prevention and reduction of withdrawal signs and symptoms in critically ill children. PROSPERO register: CRD 42021274670
DOI: 10.6084/m9.figshare.22214447.v1
title: Strategies for the management and prevention of withdrawal syndrome in critically ill pediatric patients: a systematic review

description: ABSTRACT Objective: To verify strategies for the prevention and treatment of abstinence syndrome in a pediatric intensive care unit. Methods: This is a systematic review in the PubMed database®, Lilacs, Embase, Web of Science, Cochrane, Cinahl, Cochrane Database Systematic Review and CENTRAL. A three-step search strategy was used for this review, and the protocol was approved in PROSPERO (CRD42021274670). Results: Twelve articles were included in the analysis. There was great heterogeneity among the studies included, especially regarding the therapeutic regimens used for sedation and analgesia. Midazolam doses ranged from 0.05mg/kg/hour to 0.3mg/kg/hour. Morphine also varied considerably, from 10mcg/kg/hour to 30mcg/kg/hour, between studies. Among the 12 selected studies, the most commonly used scale for the identification of withdrawal symptoms was the Sophia Observational Withdrawal Symptoms Scale. In three studies, there was a statistically significant difference in the prevention and management of the withdrawal syndrome due to the implementation of different protocols (p &lt; 0.01 and p &lt; 0.001). Conclusion: There was great variation in the sedoanalgesia regimen used by the studies and the method of weaning and evaluation of withdrawal syndrome. More studies are needed to provide more robust evidence about the most appropriate treatment for the prevention and reduction of withdrawal signs and symptoms in critically ill children. PROSPERO register: CRD 42021274670
DOI: 10.6084/m9.figshare.22214448
title: Graft compatibility effects on cv. Hass avocado fruit growth

description: ABSTRACT The rootstock/scion morphological alterations are one of the limitations in the use of grafting, which has been defined as an incompatibility between these two tissues. However the effect of rootstock-scion interactions on reproductive potential, fruit set, yield efficiency, and avocado fruit quality characteristics are complex and poorly understood. This research aimed to evaluate the fruit growth of avocado cv. Hass in trees with incompatibilities between the rootstock and the graft in the main producing regions in Colombia. The split-plot design with a locality-blocking factor was used. The main plot corresponded to the compatibility and harvest factor, and the subplots to the age of fruit development. The statistical analysis consisted of a mixed linear model for the variables of respiratory rate and morphological growth of the fruit, performing a significant multiple difference test using the adjustment for multiplicity by family through Holm’s correction. The compatibility treatment and the harvest season did not affect the fruit respiratory rate nor the variables of growth and development of cv. Hass. However, the age of development significantly affected both the respiratory rate and the variables of fruit growth.
DOI: 10.6084/m9.figshare.22214448.v1
title: Graft compatibility effects on cv. Hass avocado fruit growth

description: ABSTRACT The rootstock/scion morphological alterations are one of the limitations in the use of grafting, which has been defined as an incompatibility between these two tissues. However the effect of rootstock-scion interactions on reproductive potential, fruit set, yield efficiency, and avocado fruit quality characteristics are complex and poorly understood. This research aimed to evaluate the fruit growth of avocado cv. Hass in trees with incompatibilities between the rootstock and the graft in the main producing regions in Colombia. The split-plot design with a locality-blocking factor was used. The main plot corresponded to the compatibility and harvest factor, and the subplots to the age of fruit development. The statistical analysis consisted of a mixed linear model for the variables of respiratory rate and morphological growth of the fruit, performing a significant multiple difference test using the adjustment for multiplicity by family through Holm’s correction. The compatibility treatment and the harvest season did not affect the fruit respiratory rate nor the variables of growth and development of cv. Hass. However, the age of development significantly affected both the respiratory rate and the variables of fruit growth.
DOI: 10.6084/m9.figshare.22188004
title: Effects of transcutaneous auricular vagus nerve stimulation on inflammation, cardiac autonomic modulation, and clinical evolution of patients with COVID-19: protocol for a clinical, controlled, randomized, and blind trial

description: ABSTRACT This study aims to evaluate the effect of transcutaneous auricular vagus nerve stimulation (taVNS) on inflammation, cardiac autonomic modulation, and clinical evolution of patients with COVID-19. This is a clinical, sham-controlled, randomized, and blind trial, in which 52 hospitalized individuals diagnosed with COVID-19 will participate. They will be randomized into: experimental group (usual medical treatment associated with active taVNS) and control group (usual medical treatment associated with sham taVNS). The taVNS will be performed by a neuromuscular electric stimulator (Dualpex model 071 of Quark Medical Products), with the stimulation electrode positioned on the left tragus, with alternating current, at a 30Hz frequency with 50% variation. Intensity will be adjusted to the patient’s sensory threshold, with 90-minutes-long stimulation sessions, happening twice per day for seven consecutive days, totaling 14 sessions. Interleukin-6 (IL-6) and interleukin-10 (IL-10), cortisol and C-reactive protein (CRP), blood pressure, heart rate variability (HRV) by low frequency (LF), high frequency (HF) and low and high frequency ratio (LF/HF) parameters will be evaluated before and after the intervention, as well as patients’ clinical evolution-including anxiety and depression levels-whose data will be obtained through medical records and questionnaires. A follow-up will also be performed seven and 14 days after the end of the interventions to verify the clinical evolution, including anxiety and depression levels. Memory and attention levels will be evaluated for six months.
DOI: 10.6084/m9.figshare.22188004.v1
title: Effects of transcutaneous auricular vagus nerve stimulation on inflammation, cardiac autonomic modulation, and clinical evolution of patients with COVID-19: protocol for a clinical, controlled, randomized, and blind trial

description: ABSTRACT This study aims to evaluate the effect of transcutaneous auricular vagus nerve stimulation (taVNS) on inflammation, cardiac autonomic modulation, and clinical evolution of patients with COVID-19. This is a clinical, sham-controlled, randomized, and blind trial, in which 52 hospitalized individuals diagnosed with COVID-19 will participate. They will be randomized into: experimental group (usual medical treatment associated with active taVNS) and control group (usual medical treatment associated with sham taVNS). The taVNS will be performed by a neuromuscular electric stimulator (Dualpex model 071 of Quark Medical Products), with the stimulation electrode positioned on the left tragus, with alternating current, at a 30Hz frequency with 50% variation. Intensity will be adjusted to the patient’s sensory threshold, with 90-minutes-long stimulation sessions, happening twice per day for seven consecutive days, totaling 14 sessions. Interleukin-6 (IL-6) and interleukin-10 (IL-10), cortisol and C-reactive protein (CRP), blood pressure, heart rate variability (HRV) by low frequency (LF), high frequency (HF) and low and high frequency ratio (LF/HF) parameters will be evaluated before and after the intervention, as well as patients’ clinical evolution-including anxiety and depression levels-whose data will be obtained through medical records and questionnaires. A follow-up will also be performed seven and 14 days after the end of the interventions to verify the clinical evolution, including anxiety and depression levels. Memory and attention levels will be evaluated for six months.
DOI: 10.6084/m9.figshare.22214450
title: Computational intelligence to study the importance of characteristics in flood-irrigated rice

description: ABSTRACT. The study of traits in crops enables breeders to guide strategies for selecting and accelerating the progress of genetic breeding. Although the simultaneous evaluation of characteristics in the plant breeding programme provides large quantities of information, identifying which phenotypic characteristic is the most important is a challenge facing breeders. Thus, this work aims to quantify the best approaches for prediction and establish a network of better predictive power in flood-irrigated rice via methodologies based on regression, artificial intelligence, and machine learning. Multiple regression, computational intelligence, and machine learning were used to predict the importance of the characteristics. Computational intelligence and machine learning were notable for their ability to extract nonlinear information from model inputs. Predicting the relative contribution of auxiliary characteristics in rice through computational intelligence and machine learning proved to be efficient in determining the relative importance of variables in flood-irrigated rice. The characteristics indicated to assist in decision making are flowering, number of grains filled by panicles and length of panicles for this study. The network with only one hidden layer with 15 neurons was observed to be efficient in determining the relative importance of variables in flooded rice.
DOI: 10.6084/m9.figshare.22214450.v1
title: Computational intelligence to study the importance of characteristics in flood-irrigated rice

description: ABSTRACT. The study of traits in crops enables breeders to guide strategies for selecting and accelerating the progress of genetic breeding. Although the simultaneous evaluation of characteristics in the plant breeding programme provides large quantities of information, identifying which phenotypic characteristic is the most important is a challenge facing breeders. Thus, this work aims to quantify the best approaches for prediction and establish a network of better predictive power in flood-irrigated rice via methodologies based on regression, artificial intelligence, and machine learning. Multiple regression, computational intelligence, and machine learning were used to predict the importance of the characteristics. Computational intelligence and machine learning were notable for their ability to extract nonlinear information from model inputs. Predicting the relative contribution of auxiliary characteristics in rice through computational intelligence and machine learning proved to be efficient in determining the relative importance of variables in flood-irrigated rice. The characteristics indicated to assist in decision making are flowering, number of grains filled by panicles and length of panicles for this study. The network with only one hidden layer with 15 neurons was observed to be efficient in determining the relative importance of variables in flooded rice.
DOI: 10.6084/m9.figshare.22214451.v1
title: Selectivity and efficacy of PROTOX inhibitors in cassava varieties cultivated in clayey and sandy soils

description: ABSTRACT. The selectivity and efficacy of protoporphyrinogen oxidase (PROTOX) inhibitor herbicides in cassava varieties depend on product formulation, dosage, and soil texture. The aim of this study was to assess the selectivity and efficacy of flumioxazin and sulfentrazone in the cassava variety ‘IPR B36’ and the clone ‘VN 117’. Two experiments were carried out: one in a clayey soil and one in a sandy soil. Both experiments were laid in a split-plot randomized block design with three replicates. The two cassava varieties were used as main plots, with subplots consisting in 10 treatments including, flumioxazin at 50, 75, 100, and 125 g ha-1; sulfentrazone at 250, 500, 750, and 1000 g ha-1; one weed-free control, and one unweeded control. Flumioxazin (≥75 g ha-1) and sulfentrazone (≥250 g ha-1) achieved mean weed control rates &gt; 70 and 90% in both types of soil for up to 90 days after application. Flumioxazin exhibited fewer residual effects on the cassava varieties than sulfentrazone, particularly in clayey soil. Flumioxazin was selective to the different cassava varieties planted in both soil types, whereas sulfentrazone was more selective in clayey soil. PROTOX inhibitors were effective in controlling weed growth in cassava plots, and there were no varietal differences in herbicide selectivity; however, the use of sulfentrazone should be restricted to maximum spray rates of 250 g ha-1 in sandy soils.
DOI: 10.6084/m9.figshare.22214451
title: Selectivity and efficacy of PROTOX inhibitors in cassava varieties cultivated in clayey and sandy soils

description: ABSTRACT. The selectivity and efficacy of protoporphyrinogen oxidase (PROTOX) inhibitor herbicides in cassava varieties depend on product formulation, dosage, and soil texture. The aim of this study was to assess the selectivity and efficacy of flumioxazin and sulfentrazone in the cassava variety ‘IPR B36’ and the clone ‘VN 117’. Two experiments were carried out: one in a clayey soil and one in a sandy soil. Both experiments were laid in a split-plot randomized block design with three replicates. The two cassava varieties were used as main plots, with subplots consisting in 10 treatments including, flumioxazin at 50, 75, 100, and 125 g ha-1; sulfentrazone at 250, 500, 750, and 1000 g ha-1; one weed-free control, and one unweeded control. Flumioxazin (≥75 g ha-1) and sulfentrazone (≥250 g ha-1) achieved mean weed control rates &gt; 70 and 90% in both types of soil for up to 90 days after application. Flumioxazin exhibited fewer residual effects on the cassava varieties than sulfentrazone, particularly in clayey soil. Flumioxazin was selective to the different cassava varieties planted in both soil types, whereas sulfentrazone was more selective in clayey soil. PROTOX inhibitors were effective in controlling weed growth in cassava plots, and there were no varietal differences in herbicide selectivity; however, the use of sulfentrazone should be restricted to maximum spray rates of 250 g ha-1 in sandy soils.
DOI: 10.6084/m9.figshare.22214454
title: How do relocation time and length of storage after relocation affect fermentation and nutritive value of corn silage?

description: ABSTRACT This study aimed to determine the effects of relocation time (RT; Experiment 1) and storage time after relocation (ST; Experiment 2) on microbial population, fermentative characteristics, and chemical composition of corn silage. In experiment 1, corn silage was stored for 30 d, subjected to different RT (0–60 h), and stored again for 30 d. Thirty experimental silos were used in a completely randomized design, with three replicates per treatment. In experiment 2, after 150 d of ensiling, silage was removed from a bunker silo, exposed to air for 9 h, relocated to experimental silos, and stored for periods ranging from 0 to 128 d. Twenty-eight experimental silos were used in a completely randomized design, with four replicates per treatment. Relocation time had no effect on fungi counts and concentrations of lactic and propionic acids in corn silage but resulted in a significant increase in dry matter content. In experiment 2, dry matter recovery and concentration of non-fiber carbohydrates decreased in corn silage stored for more than 32 d after relocation. Exposure of corn silage to air during relocation for up to 60 h followed by 30 d of storage did not compromise the fermentation profile or nutritive value of the silage. Increased storage time of relocated corn silage (up to 128 d) consistently decreases its nutritional value. The storage period seems to have an increased impact on nutrient loss in relocated silage than the relocation period.