cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.5398477
title: Supplementary Material for: Euflammation Attenuates Central and Peripheral Inflammation and Cognitive Consequences of an Immune Challenge after Tumor Development

description: <b><i>Objective:</i></b> Repeated subthreshold bacterial exposures in rodents cause novel euflammation that attenuates neuroinflammation and sickness behaviors upon subsequent infectious challenges to the host without eliciting illness behavior. The investigation of bacterial exposure effects on brain and behavior is clinically relevant because bacterial-based antitumor treatments are used successfully, but are suboptimal due to their illness side effects. In addition, behavioral consequences (depression, cognitive impairments) to homeostatic challenges that are associated with inflammation are prevalent and reduce the quality of life in cancer patients and survivors. Therefore, this study tested the potential for euflammation to attenuate behavioral consequences of an immune challenge in tumor-bearing mice. <b><i>Methods:</i></b> Mice with and without oral tumors in their flank underwent the established peripheral euflammatory protocol or vehicle treatment, followed by an acute peripheral immune challenge (lipopolysaccharide [LPS] injection) or PBS. Cognitive function and sickness behavior were assessed after the challenge, and peripheral and central inflammatory responses were measured. <b><i>Results:</i></b> Euflammation reduced LPS-induced peripheral and central inflammation in all mice; however, neuroinflammation was less attenuated in tumor-bearing mice compared with tumor-free controls. LPS-induced lethargy and cognitive impairments were more pronounced among tumor-bearing mice and were effectively attenuated with euflammation. Cognitive changes were independent of brain-derived growth factor gene expression in the hippocampus. <b><i>Conclusion:</i></b> These results suggest that induction of euflammation may be useful in alleviating the negative side effects of bacterial-based tumor treatments and in potentially attenuating common behavioral comorbidities associated with cancer or other chronic diseases.
DOI: 10.6084/m9.figshare.5398390
title: Auditory Rhythms Influence Judged Time to Contact of an Occluded Moving Object. Supplementary Figures

description: We studied the expected moment of reappearance of a moving object after it disappeared from sight. In particular, we investigated whether auditory rhythms influence time to contact (TTC) judgments. Using displays in which a moving disk disappears behind an occluder, we examined whether an accompanying auditory rhythm influences the expected TTC of an occluded moving object. We manipulated a baseline auditory rhythm — consisting of equal sound and pause durations — in two ways: either the pause durations or the sound durations were increased to create slower rhythms. Participants had to press a button at the moment they expected the disk to reappear. Variations in pause duration (Experiments 1 and 2) affected expected TTC, in contrast to variations in sound duration (Experiment 3). These results show that auditory rhythms affect expected reappearance of an occluded moving object. Second, these results suggest that temporal auditory grouping is an important factor in TTC.
DOI: 10.6084/m9.figshare.5398396
title: Supplementary Material for: A Novel Missense GLA Mutation (p.G35V) Detected in Hemodialysis Screening Leads to Severe Systemic Manifestations of Fabry Disease in Men and Women

description: <i>Background/Aims:</i> Fabry disease (FD), an X-linked lysosomal storage disorder, leads to accumulation of globotriaosylceramide. Screening in dialysis patients may identify genetic variants of unknown clinical significance. We aimed to characterize the pathogenicity of a novel <i>GLA</i> gene mutation identified during hemodialysis screening and the histologic findings of early Fabry nephropathy. <i>Methods:</i> One out of 108 male hemodialysis patients screened for FD presented low α-galactosidase A activity. A novel missense mutation (p.G35V) in the <i>GLA</i> gene was detected. Family screening identified 11 additional cases (8 women). Clinical investigation was conducted in 10 patients (index case and 9 relatives). Pathogenicity of the new mutation was investigated by clinical and laboratory tests, cardiac and cranial magnetic resonance imaging, and kidney biopsy. <i>Results:</i> Cardiac manifestations were detected in most patient from both genders, such as left ventricular hypertrophy and short PR interval. White matter lesion was present in 3 women. Pulvinar lesion of the thalamus and ischemic stroke were detected in male patients. Abnormal glomerular filtration rate (GFR) and/or albuminuria were present in 5 patients (3 women). Renal biopsies (<i>n</i> = 7) revealed globotriaosylceramide deposits in different cell types and foot processes effacement in all patients, including women with normal albuminuria. Despite a normal GFR, tubulointerstitial fibrosis ranging from 5 to 20% was present in young women and men with normal or high albuminuria, respectively. <i>Conclusion:</i> The novel missense mutation p.G35V leads to severe systemic manifestations of FD in men and women. Kidney histological changes, including tubulointerstitial fibrosis, may predate albuminuria and GFR changes in adult women. Novel non-invasive markers are required for early detection of Fabry nephropathy.
DOI: 10.6084/m9.figshare.5398396.v1
title: Supplementary Material for: A Novel Missense GLA Mutation (p.G35V) Detected in Hemodialysis Screening Leads to Severe Systemic Manifestations of Fabry Disease in Men and Women

description: <i>Background/Aims:</i> Fabry disease (FD), an X-linked lysosomal storage disorder, leads to accumulation of globotriaosylceramide. Screening in dialysis patients may identify genetic variants of unknown clinical significance. We aimed to characterize the pathogenicity of a novel <i>GLA</i> gene mutation identified during hemodialysis screening and the histologic findings of early Fabry nephropathy. <i>Methods:</i> One out of 108 male hemodialysis patients screened for FD presented low α-galactosidase A activity. A novel missense mutation (p.G35V) in the <i>GLA</i> gene was detected. Family screening identified 11 additional cases (8 women). Clinical investigation was conducted in 10 patients (index case and 9 relatives). Pathogenicity of the new mutation was investigated by clinical and laboratory tests, cardiac and cranial magnetic resonance imaging, and kidney biopsy. <i>Results:</i> Cardiac manifestations were detected in most patient from both genders, such as left ventricular hypertrophy and short PR interval. White matter lesion was present in 3 women. Pulvinar lesion of the thalamus and ischemic stroke were detected in male patients. Abnormal glomerular filtration rate (GFR) and/or albuminuria were present in 5 patients (3 women). Renal biopsies (<i>n</i> = 7) revealed globotriaosylceramide deposits in different cell types and foot processes effacement in all patients, including women with normal albuminuria. Despite a normal GFR, tubulointerstitial fibrosis ranging from 5 to 20% was present in young women and men with normal or high albuminuria, respectively. <i>Conclusion:</i> The novel missense mutation p.G35V leads to severe systemic manifestations of FD in men and women. Kidney histological changes, including tubulointerstitial fibrosis, may predate albuminuria and GFR changes in adult women. Novel non-invasive markers are required for early detection of Fabry nephropathy.
DOI: 10.6084/m9.figshare.5398384.v1
title: NC01 - Nasal Cavity 01

description: A reconstructed nasal cavity from CT-scans. The nasal cavity is in .tin file format. The demographic data for the model is a healthy 25 year old, healthy non-smoking Asian male (170 cm height, 75 kg mass)<br><br>Journal publications using this model:NASAL SPRAY DRUG DELIVERYInthavong, K. Tian ZF, Tu JY, Yang W, Xue C (2008) Optimising nasal spray parameters for efficient drug delivery using computational fluid dynamics. Computers in Biology and Medicine 38(6):713-26.Tian ZF, Inthavong, K. Tu JY (2007) Deposition of inhaled wood dust in the nasal cavity. Inhalation Toxicology 19(14):1155-65Inthavong, K. Tian ZF, Li HF, Tu JY, Yang W, Xue CL (2006) A numerical study of spray particle deposition in a human nasal cavity. Aerosol Science Technology 40(11):1034-45INHALATION TOXICOLOGYKing Se CM, Inthavong, K. Tu J. (2010) Inhalability of micron particles through the nose and mouth. Inhalation Toxicology 22(4):287-300.Inthavong, K. Tu JY, Ahmadi G. (2009) Computational modelling of gas-particle flows with different particle morphology in the human nasal cavity Journal of Computational Multiphase Flows 1(1):57-82Wang SM, Inthavong, K. Wen J, Tu JY, Xue CL (2009) Comparison of micron- and nanoparticle deposition patterns in a realistic human nasal cavity. Respiratory Physiology Neurobiology 166(3):142-151Inthavong, K. Wen J, Tian ZF, Tu JY. (2008) Numerical study of fibre deposition in a human nasal cavity. Journal of Aerosol Science 39(3):253-65.RESPIRATORY PHYSIOLOGYInthavong, K. Tu J, Ye Y, Ding S, Subic A, Thien F. (2010) Effects of airway obstruction induced by asthma attack on particle deposition. Journal of Aerosol Science 41(6):587-601.Inthavong, K. Choi L-T, Tu J, Ding S, Thien F. (2010) Micron particle deposition in a tracheobronchial airway model under different breathing conditions. Medical Engineering ;amps Physics 32(10):1198-212.Se, C., Inthavong, K. and Tu, J.Y. (2010). Unsteady particle deposition in a human nasal cavity during inhalation. Journal of Computational Multiphase Flows 2:207-218Inthavong, K. Wen J, Tu JY, Tian ZF, (2009) From CT scans to CFD modelling fluid and heat transfer in a realistic human nasal cavity. Engineering Applications of Computational Fluid Mechanics 3(3):321-35.Wen J, Inthavong, K. Tu JY, Wang S (2008) Numerical simulations for detailed airflow dynamics in a human nasal cavity. Respiratory Physiology Neurobiology 161:125-35
DOI: 10.4225/03/59b7ce4a3f0b0
title: SAGA 2017 presentation - Combining structural analysis with sequential potential-field inversions to constrain the architecture of poly-deformed terranes

description: Combining structural analysis with sequential potential-field inversions to constrain the architecture of poly-deformed terranes
DOI: 10.6084/m9.figshare.5398312
title: Adaptive Interaction data files

description: Raw data files used for randomisation tests.
DOI: 10.6084/m9.figshare.5398258
title: example.csv

description: Fake example data<br>
DOI: 10.6084/m9.figshare.5398258.v1
title: example.csv

description: Fake example data<br>
DOI: 10.6084/m9.figshare.5398216
title: The OpenCitations Corpus n-quads data dump, archived on 2017-08-26

description: This archive contains the dump of the data included in OpenCitation Corpus (OCC, http://opencitations.net), stored as a single n-quads file.<br><br>It is worth mentioning that this dataset does not contain any provenance information about the resources, but rather it includes only the data that are available in the OCC triplestore.<br>
DOI: 10.6084/m9.figshare.5398216.v1
title: The OpenCitations Corpus n-quads data dump, archived on 2017-08-26

description: This archive contains the dump of the data included in OpenCitation Corpus (OCC, http://opencitations.net), stored as a single n-quads file.<br><br>It is worth mentioning that this dataset does not contain any provenance information about the resources, but rather it includes only the data that are available in the OCC triplestore.<br>
DOI: 10.6084/m9.figshare.5398195
title: A potent anti-inflammatory response in bat macrophages may be linked to extended longevity and viral tolerance

description: Files used for selection analyses<br>
DOI: 10.6084/m9.figshare.5398195.v1
title: A potent anti-inflammatory response in bat macrophages may be linked to extended longevity and viral tolerance

description: Files used for selection analyses<br>
DOI: 10.6084/m9.figshare.5398096
title: A new odontocete (toothed cetacean) from the Early Miocene of Peru expands the morphological disparity of extinct heterodont dolphins

description: A key step in the evolutionary history of Odontoceti (echolocating toothed cetaceans) is the transition from the ancestral heterodont condition – characterized by the presence of double-rooted cheek teeth bearing accessory denticles – to the homodont dentition displayed by most extant odontocete species. During the last few decades, new finds and the reassessment of specimens in collections revealed an increased morphological disparity amongst the Oligo–Miocene heterodont odontocetes. Based on a partly articulated skeleton from late Early Miocene (Burdigalian, 18.8–18.0 Ma) beds of the Chilcatay Formation (Pisco Basin, Peru), we describe a new genus and species of heterodont odontocete, <i>Inticetus vertizi</i>, in the new family Inticetidae. This large dolphin is characterized by, amongst other things, a long and robust rostrum bearing at least 18 teeth per quadrant; the absence of procumbent anterior teeth; many large, broad-based accessory denticles in double-rooted posterior cheek teeth; a reduced ornament of dental crowns; the styliform process of the jugal being markedly robust; a large fovea epitubaria on the periotic, with a correspondingly voluminous accessory ossicle of the tympanic bulla; and a shortened tuberculum of the malleus. Phylogenetic analyses (with and without molecular constraint; with and without down-weighting of homoplastic characters) yielded contrasting results, with <i>Inticetus</i> falling either as a stem Odontoceti or as an early branching member of a large Platanistoidea clade. With its large size, robust rostrum and unusual dental morphology, and the absence of conspicuous tooth wear, <i>Inticetus</i> increases the morphological and ecological disparity of Late Oligocene–Early Miocene heterodont odontocetes. Finally, this new taxon calls for caution when attempting to identify isolated cetacean cheek teeth, even at the suborder level. http://zoobank.org/urn:lsid:zoobank.org:pub:5B306B49-EB1B-42F9-B755-B0B05B4F938F
DOI: 10.6084/m9.figshare.5398096.v1
title: A new odontocete (toothed cetacean) from the Early Miocene of Peru expands the morphological disparity of extinct heterodont dolphins

description: A key step in the evolutionary history of Odontoceti (echolocating toothed cetaceans) is the transition from the ancestral heterodont condition – characterized by the presence of double-rooted cheek teeth bearing accessory denticles – to the homodont dentition displayed by most extant odontocete species. During the last few decades, new finds and the reassessment of specimens in collections revealed an increased morphological disparity amongst the Oligo–Miocene heterodont odontocetes. Based on a partly articulated skeleton from late Early Miocene (Burdigalian, 18.8–18.0 Ma) beds of the Chilcatay Formation (Pisco Basin, Peru), we describe a new genus and species of heterodont odontocete, <i>Inticetus vertizi</i>, in the new family Inticetidae. This large dolphin is characterized by, amongst other things, a long and robust rostrum bearing at least 18 teeth per quadrant; the absence of procumbent anterior teeth; many large, broad-based accessory denticles in double-rooted posterior cheek teeth; a reduced ornament of dental crowns; the styliform process of the jugal being markedly robust; a large fovea epitubaria on the periotic, with a correspondingly voluminous accessory ossicle of the tympanic bulla; and a shortened tuberculum of the malleus. Phylogenetic analyses (with and without molecular constraint; with and without down-weighting of homoplastic characters) yielded contrasting results, with <i>Inticetus</i> falling either as a stem Odontoceti or as an early branching member of a large Platanistoidea clade. With its large size, robust rostrum and unusual dental morphology, and the absence of conspicuous tooth wear, <i>Inticetus</i> increases the morphological and ecological disparity of Late Oligocene–Early Miocene heterodont odontocetes. Finally, this new taxon calls for caution when attempting to identify isolated cetacean cheek teeth, even at the suborder level. http://zoobank.org/urn:lsid:zoobank.org:pub:5B306B49-EB1B-42F9-B755-B0B05B4F938F
DOI: 10.6084/m9.figshare.5398093
title: A phylogenetic perspective on the influence of ecological attributes on selected species of <i>Astragalus</i>

description: The use of phylogeny in ecology has gained attention due to its benefits in understanding biological diversity and adaptation processes. In this study, phylogenetic positions of 12 <i>Astragalus</i> taxa were evaluated by comparing with 419 <i>Astragalus</i> taxa sequences in a database. Additionally, the influence of ecological traits on morphology was assessed. Although the samples were grouped according to subgenera or sections they belong to, this division was not striking. The phylogenetic relationships of the nine endemic and three common <i>Astragalus</i> taxa based on nrDNA region sequences and morphological features as well as their interplay with the environment were examined. Furthermore, soil characteristics of the fields where each <i>Astragalus</i> taxon grows were determined. Analysis of the sequences revealed that the 12 taxa were grouped into three clades using the Bayesian Inference method. A cladogram of 431 <i>Astragalus</i> taxa showed that the samples were divided into ten major clades. Morphological traits were found to be correlated with soil properties, which could indicate adaptation to environmental conditions of these taxa.
DOI: 10.6084/m9.figshare.5398093.v1
title: A phylogenetic perspective on the influence of ecological attributes on selected species of <i>Astragalus</i>

description: The use of phylogeny in ecology has gained attention due to its benefits in understanding biological diversity and adaptation processes. In this study, phylogenetic positions of 12 <i>Astragalus</i> taxa were evaluated by comparing with 419 <i>Astragalus</i> taxa sequences in a database. Additionally, the influence of ecological traits on morphology was assessed. Although the samples were grouped according to subgenera or sections they belong to, this division was not striking. The phylogenetic relationships of the nine endemic and three common <i>Astragalus</i> taxa based on nrDNA region sequences and morphological features as well as their interplay with the environment were examined. Furthermore, soil characteristics of the fields where each <i>Astragalus</i> taxon grows were determined. Analysis of the sequences revealed that the 12 taxa were grouped into three clades using the Bayesian Inference method. A cladogram of 431 <i>Astragalus</i> taxa showed that the samples were divided into ten major clades. Morphological traits were found to be correlated with soil properties, which could indicate adaptation to environmental conditions of these taxa.
DOI: 10.6084/m9.figshare.5398042
title: Triazavirine supramolecular complexes as modifiers of the peptide oligomeric structure

description: In this study, we present molecular dynamics simulations of the antiviral drug triazavirine, that affects formation of amyloid-like fibrils of the model peptide (SI). According to our simulations, triazavirine is able to form linear supramolecular structures which can act as shields and prevent interactions between SI monomers. This model, as validated by simulations, provides an adequate explanation of triazavirine’s mechanism of action as it pertains to SI peptide fibril formation.
DOI: 10.6084/m9.figshare.5398027
title: replicationDemos_1.13.tar.gz

description: R-package for replicating skeptical papers on climate change <br>
DOI: 10.6084/m9.figshare.5398042.v1
title: Triazavirine supramolecular complexes as modifiers of the peptide oligomeric structure

description: In this study, we present molecular dynamics simulations of the antiviral drug triazavirine, that affects formation of amyloid-like fibrils of the model peptide (SI). According to our simulations, triazavirine is able to form linear supramolecular structures which can act as shields and prevent interactions between SI monomers. This model, as validated by simulations, provides an adequate explanation of triazavirine’s mechanism of action as it pertains to SI peptide fibril formation.
DOI: 10.6084/m9.figshare.5398027.v1
title: replicationDemos_1.13.tar.gz

description: R-package for replicating skaptical papers on climate change <br>
DOI: 10.6084/m9.figshare.5398015
title: Hemodynamic responses in prefrontal cortex and personality variables in bulimic disorders

description: Hemodynamic responses in prefrontal cortex and personality variables in 20 patients were compared with those of 23 healthy subjects.
DOI: 10.6084/m9.figshare.5398015.v1
title: Hemodynamic responses in prefrontal cortex and personality variables in bulimic disorders

description: Hemodynamic responses in prefrontal cortex and personality variables in 20 patients were compared with those of 23 healthy subjects.
DOI: 10.6084/m9.figshare.5397205
title: data for experiments and simulations.pdf

description: The data is for the paper on plos one named 'Preliminary research on flow rate and free surface of the accelerator driven subcritical system gravity-driven dense granular-flow target'.<br>
DOI: 10.6084/m9.figshare.5397160
title: Excess Mortality Related to Chikungunya Epidemics in the Context of Co-circulation of Other Arboviruses in Brazil

description: These data were used as a basis for the manuscript entitled "Excess Mortality Related to Chikungunya Epidemics in the Context of Co-circulation of Other Arboviruses in Brazil"
DOI: 10.6084/m9.figshare.5397097
title: 2017-09-11_Cambridge

description: Small example of long-wide table format
DOI: 10.6084/m9.figshare.5397055
title: Largest Prime Number

description: I used a factoring calculator from factoring-calculator.net to find the prime number contained in this document.
DOI: 10.6084/m9.figshare.5397097.v1
title: 2017-09-11_Cambridge

description: Small example of long-wide table format
DOI: 10.6084/m9.figshare.5397055.v1
title: Largest Prime Number

description: I used a factoring calculator from factoring-calculator.net to find the prime number contained in this document.
DOI: 10.6084/m9.figshare.5396989
title: Comparison of bioavailability and antiplatelet action of ticagrelor in STEMI versus NSTEMI patients

description: Comparison of bioavailability and antiplatelet action of ticagrelor in patients with ST-elevation myocardial infarction and non-ST-elevation myocardial infarction: a prospective, observational, single-centre study<br>
DOI: 10.6084/m9.figshare.5396989.v1
title: Comparison of bioavailability and antiplatelet action of ticagrelor in STEMI versus NSTEMI patients

description: Comparison of bioavailability and antiplatelet action of ticagrelor in patients with ST-elevation myocardial infarction and non-ST-elevation myocardial infarction: a prospective, observational, single-centre study<br>