DOI: 10.5061/dryad.18931zd42
title: Zona incerta distributes a broad movement signal that modulates behavior

description: The zona incerta is a subthalamic nucleus made up mostly of GABAergic
 neurons. It has wide- ranging inputs and outputs and is believed to have
 many integrative functions that link sensory stimuli with motor responses
 to guide behavior. However, its role is not well established perhaps
 because few studies have measured the activity of zona incerta neurons in
 behaving animals under different conditions. To record the activity of
 zona incerta neurons during exploratory and cue-driven goal-directed
 behaviors, we used electrophysiology in head-fixed mice moving on a
 spherical treadmill and fiber photometry in freely moving mice. We found
 two groups of neurons based on their sensitivity to movement, with a
 minority of neurons responding to whisker stimuli. Furthermore, zona
 incerta GABAergic neurons robustly code the occurrence of exploratory and
 goal-directed movements, but not their direction. To understand the
 function of these activations, we performed genetically targeted lesions
 and optogenetic manipulations of zona incerta GABAergic neurons during
 exploratory and goal-directed behaviors. The results showed that the zona
 incerta has a role in modulating the movement associated with these
 behaviors, but this has little impact on overall performance. Zona incerta
 neurons distribute a broad corollary signal of movement occurrence to
 their diverse projection sites, which regulates behavior.
description: The details are described in the associated eLife paper. 
description: # Zona incerta distributes a broad movement signal that modulates behavior
 The data correspond to the figures and panels shown in the published
 paper. ## Description of the data and file structure All files are .ogwu
 books from Originlab. Find the free reader online here:
 All files are labeled according
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 paper. The books include defining metadata shown as parameter rows or
 indexed columns. These refer to information related to the plots shown in
 the paper. Each book contains traces (time series) or measured values as
 noted below. Any additional data or metadata in the books (not listed
 below) are not detailed/included in the related paper. ### Fig1C:
 **Event**: (=) Cxp or (=) Cxp4 **Class2**: type of cell **Site**: site ID
 ### Fig2AB: **Long Name**: stimulation protocol **Cell**: cell ID
 **Class1**: type of cell **Class2**: type of cell ### Fig3BC: **File**:
 filename **Event**: event ID **Variable**: variable ID (as explained in
 the paper) **Class1**: type of cell **Animal**: animal ID **EventVar**:
 variable + event IDs **Site**: site ID ### Fig4-6 and Fig8CD: #### Traces:
 **File**: filename **Animal**: animal ID **SesName**: name of session
 **Session**: session number  **getFile**: animal ID + traced variable ID
 ### Measures:  **File**: filename **Variable**: measured variable ID
 **Animal**: animal ID **Area**: measured area under the curve **Max**:
 measured max value **xMax**: time to Max **Min**: measured min value
 **xMin**: time to Min **Pk**: measured absolute peak value **xPk**: time
 to Pk ### Fig8B: **Animal**: animal ID **Session**: session number
 **Code**: session code **NumofTrial**: number of total trials in session
 **Avoids%**: percentage of avoids in session **Avoid** Latency: latency of
 avoid responses **ITCs/trial**: number of intertrial crossings per trial
 ### Fig9-11: #### Traces: **Animal**: animal ID **Session**: session
 number **SubSes**: subsession ID **NewCode1**: light stimulation
 **Subgroup**: animal group ID (e.g. No Opsin, Vgat-ZI-Arch) ### Measures:
  **Subgroup**: animal group ID **Animal**: animal ID **Session**: session
 number **SubSes**: subsession ID **NewCode1**: light stimulation **Pk7**:
 measured absolute peak value (0-4 secs) ## Sharing/Access information
 None. ## Code/Software No code is included. The raw data allows users to
 obtain the measures with their preferred method.