cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.3573447.v1
title: Ramkumar et al. (2016) Premotor and motor cortices encode reward

description: A dataset that was used in a paper by Ramkumar et al. (2016), PLoS One, to report the effect of reward on firing rates in the macaque premotor and motor cortices.
DOI: 10.11583/dtu.21750257.v1
title: Synthetic performance data for the KVLCC2

description: The data comprises of two different concept drift scenarios: Sudden (SCD) and Incremental (ICD) concept drift. Moreover, three different datasets per scenario are available, which all show different sources of uncertainty. In fact, dataset A has a negigible degrees of epistemic and aleatoric uncertainty, whereas B introduces epistemic and C shows aleatoric uncertainty. The individual columns are: Speed, draft (fore and aft), significant wave height, peak period, rel. wave direction, rel. wind speed, rel. wind direction, shaft torque, power and rpm, water temperature and finally the biofouling scenario. The columns include a title with corresponding units. The files are saved in binary feather format for efficiency reasons. For more information, please consult the readme file or the upcoming paper. <br>
DOI: 10.17632/grffnvg89n
title: Modularity of PRC1 Composition and Chromatin Interaction define Condensate Properties; Niekamp et al.; part 1 of 5

description: This project is described in: Modularity of PRC1 Composition and Chromatin Interaction define Condensate Properties (2023) and can be found on BioRxiv: https://www.biorxiv.org/content/10.1101/2023.10.26.564217v2

Here, we provide the experimental data together with the custom python code and ImageJ macros used for data analysis. Details on how the code works are given in the script itself.

This is part 1 of 5.

Part 1: Data for Figure 1, 2, and 3
Part 2: Data for Figure 4, 5, 6, and 7
Part 3: Data for Figure S1, S2, S3, S4, and S5
Part 4: Data for Figure S6
Part 5: Data for Figure S7
DOI: 10.17632/y2j4k2mkd6
title: Cryo-EM Structures of SARS-CoV-2 Spike without and with ACE2 Reveal a pH-Dependent Switch to Mediate Endosomal Positioning of Receptor-Binding Domains. Zhou et al.

description: Supplemental Video Legends: Video S1. A side-view movie illustrating the trajectory of the 3D covariance described by eigenvector 0 in 3D variability analysis of individual spike at pH 5.5 (see Methods for a detailed description). A ratcheting motion of one NTD domain results in increased mobility of the corresponding RBD. A corresponding top view is presented in Video S2. Video S2. A top-view movie illustrating the trajectory of the 3D covariance described by eigenvector 0 in 3D variability analysis of individual spike at pH 5.5 (see Methods for a detailed description). The RBD is up and alternates between two positions. A corresponding side view is presented in Video S1. Video S3. A side-view movie illustrating the trajectory of the 3D covariance described by eigenvector 2 in 3D variability analysis of individual spike at pH 5.5 (see Methods for a detailed description). A ratcheting motion of one NTD domain results in increased mobility of the corresponding RBD. A corresponding top view is presented in Video S4. Video S4. A top-view movie illustrating the trajectory of the 3D covariance described by eigenvector 2 in 3D variability analysis of individual spike at pH 5.5 (see Methods for a detailed description). The RBD alternates between up and down positions. A corresponding side view is presented in Video S3. Video S5. pH-dependent domain movements in the SARS-CoV-2 spike and pH-switch refolding.
DOI: 10.17866/rd.salford.28443968.v1
title: 20/01/2025 - Wigan and Leigh National College Podcast

description: Lecture on Bessie Head by Jade Munslow Ong<br>Followed by National College Podcast led by Jade Munslow Ong, accompanied by Noah Singh-Harris and Jimmy Ewing's media student Sophie Hollis<br><br>Number of students: 12<br>Student and Teacher Questionnaires + Postcards collected
DOI: 10.6084/m9.figshare.26537743.v1
title: Supplementary Material for: Associations between earlobe creases and MRI SVD markers in a Chinese cohort of patients with ischemic stroke

description: BACKGROUND: The association between earlobe crease (ELC) and cerebral small vessel disease (CSVD), including white matter hyperintensities (WMHs) and brain atrophy, is unclear, especially in the setting of acute ischemic stroke (AIS). Here, we aimed to investigate the association between ELC and WMHs as well as brain atrophy among AIS patients.
METHODS: A total of 730 AIS patients from China were enrolled. Patients were divided into groups without and with ELC, unilateral and bilateral ELC according to pictures of bilateral ears. Logistic regression models were employed to assess the impact of ELC, bilateral ELC on WMHs, periventricular hyperintensities (PVH), deep white matter hyperintensities (DWMH), and brain atrophy, as measured by the Fazekas scale and global cortical atrophy scale, in brain magnetic resonance imaging (MRI). 
RESULTS: There were 520 (71.2%) AIS patients with WMHs, 445 (61.0%) with PVH, 462 (63.3%) with DWMH and 586 (80.3%) with brain atrophy. Compared to those without ELC, patients with ELC were significant associated with an increased risk of PVH (odds ratio [OR] 1.79; 95% confidence interval [CI], 1.15-2.77) and brain atrophy (OR 6.18; 95% CI, 3.60-10.63), but not WMHs and DWMH. The presence of bilateral ELC significantly increased the odds of WMHs (OR 1.60; 95% CI, 1.00-2.56), PVH (OR 1.87; 95% CI, 1.18-2.96), and brain atrophy (OR 8.50; 95% CI, 4.62-15.66) when compared to individuals without ELC. Furthermore, we discovered that the association between bilateral ELC and WMHs, PVH, and DWMH was significant only among individuals aged ≤68 (median age) years (all P trend ≤0.041). However, this association was not observed in patients older than 68 years. 
CONCLUSIONS: In Chinese AIS patients, the presence of the visible aging sign, ELC, especially bilateral ELC, showed independent associations with both white matter hyperintensities and brain atrophy, particularly among those younger than 68 years old.
DOI: 10.17632/2wghjchjnv
title: SES Analysis Data

description: This data set contains the socioeconomic and ecological variables that have been modeled to green coverage as the response variable. All numbers are standardized to facilitate the comparison of effects in the final model.
DOI: 10.23645/epacomptox.6062623.v2
title: ToxCast Database (invitroDB)

description: ToxCast high-throughput assay information including assay annotation user guide, assay target information, study design information and quality statistics on the assays.
DOI: 10.6084/m9.figshare.5540359.v6
title: National Gallery (London), Exhibitions, 1999 to 2020

description: This dataset temporary exhibitions hosted at the National Gallery, London from 1999 to 31st March 2021 <br> It includes details of artistic period, space, sponsors, visitor numbers, dates and other information taken from the National Gallery website and published reports. <br> Full documentation is available in the accompanying pdf file.
DOI: 10.6084/m9.figshare.c.3686815_d1.v1
title: Additional file 1: of Transformation of 5-D itch scale and numerical rating scale in chronic hemodialysis patients

description: Raw data. (XLSX 18 kb)
DOI: 10.6084/m9.figshare.7271441.v1
title: Evapotranspiration 2013 - 2015

description: These evapotranspiration data were used in the research article published in 2018 by Ecological Applications titled "Assessing regional drought impacts on vegetation and evapotranspiration: a case study in Guanacaste, Costa Rica" by Savannah S. Cooley, Christopher A. Williams, Joshua B. Fisher, Gregory H. Halverson, Johan Perret, and Christine M. Lee.<br>The algorithm used to produce evapotranspiration estimates is called Priestley-Taylor Jet Propulsion Laboratory (PT-JPL) model (Fisher et al., 2008). See: https://doi.org/10.1016/j.rse.2007.06.025
DOI: 10.6084/m9.figshare.1144505.v1
title: Universal Portrait/Landscape Tecan EVO One-Place MTP Carrier

description: .STL file for 3D Printing Custom labware design: Single position plate carrier with slots for pins corresponding to Tecan Freedom EVO deck, designed such that the center of the plate is at the same position in space with respect to the deck whether the carrier is positioned in a portrait or landscape orientation. The robotic manipulator arm (RoMa) can therefore access plates on this carrier in either orientation after being trained once. Designed collaboratively by John Chodera, MSKCC; Nikki Aldeborgh, research technician in the Kayvan Keshari lab, MSKCC; Sonya Hanson, postdoctoral research fellow in Chodera Lab, MSKCC; and Julie Behr, CBM graduate student, during rotation in Chodera lab, MSKCC.
DOI: 10.6084/m9.figshare.5122732.v1
title: Supplementary Material for: Analysis of FOXG1 Is Highly Recommended in Male and Female Patients with Rett Syndrome

description: We screened a cohort of 5 male and 20 female patients with a Rett spectrum disorder for mutations in the coding region of <i>FOXG1</i>, previously shown to cause the congenital variant of Rett syndrome. Two de novo mutations were identified. The first was a novel missense mutation, p.Ala193Thr (c.577G&gt;A), in a male patient with congenital Rett syndrome, and the second was the p.Glu154GlyfsX301 (c.460dupG) truncating mutation in a female with classical Rett syndrome, a mutation that was previously reported in an independent patient. The overall rate of <i>FOXG1</i> mutations in our cohort is 8%. Our findings stress the importance of <i>FOXG1</i> analysis in male patients with Rett syndrome and in female patients when mutations in the <i>MECP2</i> and <i>CDKL5 </i>genes have been excluded.
DOI: 10.6084/m9.figshare.15156348.v1
title: Supplementary Material for: Safety and Efficacy of 2 Intracavernous Injections of Allogeneic Wharton’s Jelly-Derived Mesenchymal Stem Cells in Diabetic Patients with Erectile Dysfunction: Phase 1/2 Clinical Trial

description: <b><i>Background and Objectives:</i></b> Stem cell therapy is a novel treatment with regenerative ability that can treat erectile dysfunction (ED). This phase 1/2 clinical trial (NCT02945449) using 2 consecutive intracavernous (IC) injections of allogeneic Wharton’s jelly-derived mesenchymal stem cells (WJ-MSCs) was studied for the first time in the treatment of diabetic patients with ED. The primary outcome was to assess the safety and tolerability, and the secondary outcome was to assess the efficacy of 2 consecutive IC injections of allogeneic WJ-MSCs in diabetic ED. <b><i>Patients and Methods:</i></b> Twenty-two diabetic patients with refractory ED were included. Two consecutive IC injections of allogeneic WJ-MSCs were performed. Tolerability was assessed immediately, and at 24 h, safety was evaluated for 12 months. Efficacy was assessed using International Index of Erectile Function-5 (IIEF-5), Erection Hardness Score (EHS), and Color Duplex Doppler Ultrasound for 12 months. <b><i>Results:</i></b> The procedure was well-tolerated. Minimal and transient adverse events were redness and bruising at the site of injections. There were no patient-reported serious adverse effects. There were significant improvements in IIEF-5, EHS, peak systolic velocity (PSV) basal, and 20-min PSV, all over the follow-up time points in comparison to the baseline. <b><i>Conclusion:</i></b> This is the first human study with proven tolerability, safety, and efficacy of IC injections of allogeneic WJ-MSCs for the treatment of diabetic patients with ED.
DOI: 10.6084/m9.figshare.21952838.v2
title: Sampling flowchart.pdf

description: <strong>Aim</strong> This study aimed to evaluate the impact of self-preventive measures (handwashing, mask-wearing, and social distancing) on preventing the Coronavirus Disease-2019 (COVID-19) infection in Saudi Arabia (KSA). <strong>Methods</strong> An unmatched case-control study (1 to 1 ratio) was conducted with a sample size of 1102. The researchers used descriptive, bivariate, and multivariate analyses to determine the effect of handwashing, mask-wearing behavior, and social gatherings on COVID-19 infection. <strong>Results</strong> The results evinced that participants who believed that the facemask was important for preventing COVID-19 infection were more likely protected against the disease (OR=0.450; 0.320—0.631). Using a facemask during social visits and shopping indicated a lower protective effect than using it at work (OR=1.299; 1.011—1.668). The type of mask (disposable versus cloth; OR=0.929; 0.590—0.1.462) and its wearing period (1&lt; dayversus ≤1 day; OR=0.907; 0.662—1.243) showed an almost neutral statistical association with acquiring the infection. Contrarily, handwashing time for ≥20 seconds, compared to a shorter time, had a statistically significant protective association with the infection even after adjusting the odds ratio (OR=0.616; 0.4763—0.796). It was also noted that gathering with relatives and friends ≥4 times per month exhibited a higher and statistically significant association with the infection compared to the lower times (OR=1.347; 1.046—1.734). Furthermore, people who prayed five times a day at the mosque showed a higher risk of infection than those who prayed less than five times (adjusted OR=1.740; 1.152—2.626). <strong>Conclusions</strong> This study suggested that handwashing for more than 20 seconds is the most important preventive factor among all considerations investigated. Moreover, it was noticed that disposable and cloth facemasks may have the same effect regardless of the wearing period or sterilization status. Furthermore, gathering with relatives and friends, as well as praying five times a day at the mosque, were ascertained as significant social factors in acquiring the COVID-19 infection.
DOI: 10.6084/m9.figshare.7073282.v1
title: CaF2(H2O)14 minima obtained at HF and MP2 levels

description: CaF2(H2O)14 minima obtained at the HF/6-31* and MP2/6-311++G** levels of theory. Electronic energy and ZPE included in each file.
DOI: 10.17632/2pzjthx2k3
title: Human Time Cell Code

description: Representative MATLAB code used to isolate time cells from human intracranial microelectrode recordings.
DOI: 10.6084/m9.figshare.16895419.v1
title: March 2021 Covid-19 + Vaccines Twitter Streaming Dataset

description: The file contains Tweet IDs* for COVID-19 related tweets collected in <b>March, 2021</b> from <b>Twitter's COVID-19 Streaming Endpoint </b>via a custom script developed by the <b>Social Media Lab (https://socialmedialab.ca/)</b>.<br>Visit <b>our interactive dashboard at https://stream.covid19misinfo.org</b>/ for a preview and some general stats about this COVID-19 Twitter streaming dataset.<br>For more info about <b>Twitter's COVID-19 Streaming Endpoint</b>, visit <b>https://developer.twitter.com/en/docs/labs/covid19-stream/overview</b><br><b>Note</b>: In accordance with Twitter API Terms, the dataset only includes Tweet IDs (as opposed to the actual tweets and associated metadata). To recollect tweets contained in this dataset, you can use programs such as Hydrator (https://github.com/DocNow/hydrator/) or the Python library Twarc (https://github.com/DocNow/twarc/).
DOI: 10.6084/m9.figshare.12941660.v1
title: Supplementary Material for: Benefits and Limitations of TKIs in Patients with Medullary Thyroid Cancer: A Systematic Review and Meta-Analysis

description: <b><i>Introduction:</i></b> Tyrosine kinase inhibitors (TKIs) have been used in patients with advanced medullary thyroid carcinoma (MTC); however, data on their effectiveness and safety are limited. The aim of this systematic review and meta-analysis was to document clinical response and toxicities of TKIs in advanced MTC. <b><i>Methods:</i></b> We systematically searched major databases for articles or abstracts on TKI use in MTC patients until May 2018. Objective response (OR), defined as the sum of complete + partial response, expressed as percentage, was our primary endpoint, while disease stability, disease progression (DP), median progression-free survival (PFS), and drug discontinuation rate due to adverse events (AEs) were secondary endpoints. Pooled percentages, PFS time, and 95% CIs were reported. <b><i>Results:</i></b> Thirty-three publications were finally included in the analysis: 1 phase IV, 2 phase III trials evaluating vandetanib and cabozantinib, respectively, 20 phase I or II studies, and the remaining 10 studies of retrospective-observational nature. OR was documented in 28.6% (95% CI 25.9–31.9) of patients. Stable disease was recorded in 46.2% (95% CI 43.3–49.1). Overall, DP was observed in 22.9% (95% CI 20.4–27.6). Grade 3 or more AEs occurred in 48.5% (95% CI 45.5–51.5) of patients, and drug discontinuation was reported in 44.7% (95% CI 41.7–47.6). In general, use of TKIs conferred a PFS of 23.3 months (95% CI 21.07–25.5). In particular, vandetanib induced an OR in 33.8% (95% CI 29.6–38.0) of patients and cabozantinib in 27.7% (95% CI 22.05–33.4). DP occurred in 23.7% (95% CI 19.9–27.6) with vandetanib use and in 22.6% (95% CI 17.4–27.9) in cabozantinib-treated patients. Sorafenib, the third most frequently studied drug, showed intermediate efficacy, but higher discontinuation rates. <b><i>Conclusion:</i></b> Treatment with TKIs in MTC patients with progressive disease is associated with a moderate therapeutic benefit, with achievement of either disease stability or partial response in 73%. The toxicity of these drugs is not negligible, but it is, nonetheless, manageable.
DOI: 10.6084/m9.figshare.20268738.v1
title: Tokyo Vulerability and Healthcare Accessibility

description: The ongoing multi-wave COVID-19 pandemic has disproportional impacts on people with different demographic and socioeconomic background, and their access to healthcare facilities. Vulnerable neighborhoods with low healthcare access are places most needed for the enhancement of medical resources and services. Measuring vulnerability to COVID-19 and healthcare accessibility at the fine-grained level serves as the foundation for spatially explicit health planning and policy making in response to future public health crisis. Despite of its importance, the evaluation of vulnerability and healthcare accessibility is insufficient in Japan—a nation with high population density and super-aging challenge. Drawing on the latest 2022 census data at the smallest statistical unit, as well as transport network, medical and digital cadastral data, land use maps, and points of interest data, our study reformulates the concept of vulnerability in the context of COVID-19 and constructs the first fine-grained measure of vulnerability and healthcare accessibility in Tokyo Metropolis, Japan—the most popular metropolitan region in the world. We delineate the vulnerable neighborhoods with low healthcare access and further evaluate the disparity in healthcare access and built environment of areas at different levels of vulnerability. Our outcome datasets and findings provide nuanced and timely evidence to government and health authorities to have a holistic and latest understanding of social vulnerability to COVID-19 and healthcare access at a fine-grained level. Our analytical framework can be employed to different geographic contexts, guiding through the place-based health planning and policy making in the post-COVID era and beyond.
DOI: 10.6084/m9.figshare.28837559.v1
title: seq_info.w_clade.expanded4.plsdb

description: seq_info.w_clade.expanded4.plsdb
DOI: 10.6084/m9.figshare.8045330.v1
title: The effects of perceived stress on hope in women with breast cancer and the role of psychological hardiness.

description: The data is in format of SPSS. It is about the moderating role of hardiness in the link between perceived stress and hope in breast cancer patients
DOI: 10.6084/m9.figshare.9785015.v1
title: Subject 21

description: Data from Subject 21
DOI: 10.6084/m9.figshare.14865030.v1
title: Supplementary Material for: Longitudinal Follow-Up Studies on the Bidirectional Association between ADL/IADL Disability and Multimorbidity: Results from Two National Sample Cohorts of Middle-Aged and Elderly Adults

description: <b><i>Background and Objectives:</i></b> Few studies have investigated the bidirectional relationship between disability and multimorbidity, which are common conditions among the older population. Based on the data from the China Health and Retirement Longitudinal Study (CHARLS) and the Survey of Health, Ageing and Retirement in Europe (SHARE), we aimed to investigate the bidirectional relationship between disability and multimorbidity. <b><i>Methods:</i></b> The activities of daily living (ADLs) and the instrumental activities of daily living (IADLs) scales were used to measure disability. In stage I, we used multinomial logistic regression to assess the longitudinal association between ADL/IADL disability and follow-up multimorbidity. In stage II, binary logistic regression was used to evaluate the multimorbidity effect on future disability. <b><i>Results:</i></b> Compared with those free of disability, people with disability possessed ascending risks for developing an increasing number of diseases. For ADL disability, the odds ratio (OR) (95% confidence interval [CI]) values of developing ≥4 diseases were 4.10 (2.58, 6.51) and 6.59 (4.54, 9.56) in CHARLS and SHARE; for IADL disability, the OR (95% CI) values were 2.55 (1.69, 3.84) and 4.85 (3.51, 6.70) in CHARLS and SHARE. Meanwhile, the number of diseases at baseline was associated, in a dose-response manner, with future disability. Compared with those without chronic diseases, participants carrying ≥4 diseases had OR (95% CI) values of 4.82 (3.73, 6.21)/4.66 (3.65, 5.95) in CHARLS and 3.19 (2.59, 3.94)/3.28 (2.71, 3.98) in SHARE for developing ADL/IADL disability. <b><i>Conclusion:</i></b> The consistent findings across 2 national longitudinal studies supported a strong bidirectional association between disability and multimorbidity among middle-aged and elderly adults. Thus, tailored interventions should be taken to prevent the mutual development of disability and multimorbidity.
DOI: 10.6084/m9.figshare.26972719.v2
title: fastq files - Bacterial microbiota from blue tit feces

description: <b>Sample description</b>The dataset contains forward and reverse reads for the following samples:15 samples of 16S rRNA sequences from feces of nestling blue tits collected between May and June 2021 in Montpellier, France (43°39'56"N, 3°40'1"E);3 extraction negative controls (DNA-free water);1 positive PCR control (mock community ZymoBIOMICS Microbial Community DNA Standard (Zymo Research, Irvine, California, United States);1 negative PCR control (DNA-free water).
DOI: 10.17632/62k8sg933j
title: Time series of PM10 in 2021 year, Elk

description: Hourly concentrations of PM10_Elk_ during the period 1 January to 31 December 2021.  Were obtained from the European Environment Agency's platform available at https://discomap.eea.europa.eu/map/fme/AirQualityExport.htm/).