cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.22920164
title: Supplementary Material for: The recurrent atypical e8a2 BCR::ABL1 transcript with insertion of an inverted 55 base pair ABL1 intron 1b sequence: a detailed molecular analysis

description: Atypical BCR::ABL1 transcripts are found in approximately 2% of cases of chronic myeloid leukemia. It is important to detect them, since affected patients benefit from tyrosine kinase inhibitor therapy, similar to patients with typical BCR::ABL1 variants. In the rare e8a2 atypical BCR::ABL1 transcript two out-of-frame exons are fused, thus, interposed nucleotides are usually found at the fusion site to restore the reading frame. In approximately half of previously reported e8a2 BCR::ABL1 cases an inserted 55 bp sequence homologous to an inverted sequence from ABL1 intron 1b was detected. The generation of this recurrent transcript variant is not obvious. This work describes the molecular analysis of such an e8a2 BCR::ABL1 translocation from a CML patient. The genomic chromosomal breakpoint is identified, and the formation of this transcript variant is theoretically explained. The clinical course of the patient is reported, and recommendations are provided for the molecular analysis of future e8a2 BCR::ABL1 cases.
DOI: 10.6084/m9.figshare.22920164.v1
title: Supplementary Material for: The recurrent atypical e8a2 BCR::ABL1 transcript with insertion of an inverted 55 base pair ABL1 intron 1b sequence: a detailed molecular analysis

description: Atypical BCR::ABL1 transcripts are found in approximately 2% of cases of chronic myeloid leukemia. It is important to detect them, since affected patients benefit from tyrosine kinase inhibitor therapy, similar to patients with typical BCR::ABL1 variants. In the rare e8a2 atypical BCR::ABL1 transcript two out-of-frame exons are fused, thus, interposed nucleotides are usually found at the fusion site to restore the reading frame. In approximately half of previously reported e8a2 BCR::ABL1 cases an inserted 55 bp sequence homologous to an inverted sequence from ABL1 intron 1b was detected. The generation of this recurrent transcript variant is not obvious. This work describes the molecular analysis of such an e8a2 BCR::ABL1 translocation from a CML patient. The genomic chromosomal breakpoint is identified, and the formation of this transcript variant is theoretically explained. The clinical course of the patient is reported, and recommendations are provided for the molecular analysis of future e8a2 BCR::ABL1 cases.
DOI: 10.6084/m9.figshare.22920191
title: Supplementary Material for: The recurrent atypical e8a2 BCR::ABL1 transcript with insertion of an inverted 55 base pair ABL1 intron 1b sequence: a detailed molecular analysis

description: Atypical BCR::ABL1 transcripts are found in approximately 2% of cases of chronic myeloid leukemia. It is important to detect them, since affected patients benefit from tyrosine kinase inhibitor therapy, similar to patients with typical BCR::ABL1 variants. In the rare e8a2 atypical BCR::ABL1 transcript two out-of-frame exons are fused, thus, interposed nucleotides are usually found at the fusion site to restore the reading frame. In approximately half of previously reported e8a2 BCR::ABL1 cases an inserted 55 bp sequence homologous to an inverted sequence from ABL1 intron 1b was detected. The generation of this recurrent transcript variant is not obvious. This work describes the molecular analysis of such an e8a2 BCR::ABL1 translocation from a CML patient. The genomic chromosomal breakpoint is identified, and the formation of this transcript variant is theoretically explained. The clinical course of the patient is reported, and recommendations are provided for the molecular analysis of future e8a2 BCR::ABL1 cases.
DOI: 10.6084/m9.figshare.22920191.v1
title: Supplementary Material for: The recurrent atypical e8a2 BCR::ABL1 transcript with insertion of an inverted 55 base pair ABL1 intron 1b sequence: a detailed molecular analysis

description: Atypical BCR::ABL1 transcripts are found in approximately 2% of cases of chronic myeloid leukemia. It is important to detect them, since affected patients benefit from tyrosine kinase inhibitor therapy, similar to patients with typical BCR::ABL1 variants. In the rare e8a2 atypical BCR::ABL1 transcript two out-of-frame exons are fused, thus, interposed nucleotides are usually found at the fusion site to restore the reading frame. In approximately half of previously reported e8a2 BCR::ABL1 cases an inserted 55 bp sequence homologous to an inverted sequence from ABL1 intron 1b was detected. The generation of this recurrent transcript variant is not obvious. This work describes the molecular analysis of such an e8a2 BCR::ABL1 translocation from a CML patient. The genomic chromosomal breakpoint is identified, and the formation of this transcript variant is theoretically explained. The clinical course of the patient is reported, and recommendations are provided for the molecular analysis of future e8a2 BCR::ABL1 cases.
DOI: 10.5281/zenodo.7946433
title: Models simulating abrupt changes in the Chilika lagoon fishery, the Easter Island community, forest dieback and lake water quality

description: This deposit is in support of Willcock et al "Earlier collapse of Anthropocene ecosystems driven by multiple faster and noisier drivers". It covers the following items: (i) A list of the files contained within this data deposit; (ii) How to access and download the specialist software required to view and simulate the system dynamics models (STELLA ‘isee Player’); (iii) How to run isee Player to simulate the models; (iv) How to access and download the standard statistical software ‘R’ to run the R scripts; (v) How to load ‘R’ and modify the standard R script to analyse a subset of the model runs. This file will also details the ‘required content’ (e.g. software versions), as specified in the ‘nr-software-policy.pdf’ document. The full descriptions of each of the four system dynamics models used in this manuscript can be read in the following papers: Lake Chilika – Cooper, G. S. & Dearing, J. A. Modelling future safe and just operating spaces in regional social-ecological systems. <em>Sci. Total Environ.</em> <strong>651</strong>, 2105–2117 (2019), https://doi.org/10.1016/j.scitotenv.2018.10.118 Easter Island – Brandt, G. & Merico, A. The slow demise of Easter Island: Insights from a modeling investigation. <em>Front. Ecol. Evol.</em> <strong>3</strong>, 13 (2015), https://www.frontiersin.org/article/10.3389/fevo.2015.00013 Lake phosphorus – Wang, R. <em>et al.</em> Flickering gives early warning signals of a critical transition to a eutrophic lake state. <em>Nature</em> <strong>492</strong>, 419–22 (2012), http://dx.doi.org/10.1038/nature11655 TRIFFID - Ritchie, P. D. L., Clarke, J. J., Cox, P. M. & Huntingford, C. Overshooting tipping point thresholds in a changing climate. <em>Nat. 2021 5927855</em> <strong>592</strong>, 517–523 (2021), http://dx.doi.org/10.1038/nature11655
DOI: 10.5281/zenodo.7640950
title: Models simulating abrupt changes in the Chilika lagoon fishery, the Easter Island community, forest dieback and lake water quality

description: This deposit is in support of Willcock et al "Earlier collapse of Anthropocene ecosystems driven by multiple faster and noisier drivers". It covers the following items: (i) A list of the files contained within this data deposit; (ii) How to access and download the specialist software required to view and simulate the system dynamics models (STELLA ‘isee Player’); (iii) How to run isee Player to simulate the models; (iv) How to access and download the standard statistical software ‘R’ to run the R scripts; (v) How to load ‘R’ and modify the standard R script to analyse a subset of the model runs. This file will also details the ‘required content’ (e.g. software versions), as specified in the ‘nr-software-policy.pdf’ document. The full descriptions of each of the four system dynamics models used in this manuscript can be read in the following papers: Lake Chilika – Cooper, G. S. & Dearing, J. A. Modelling future safe and just operating spaces in regional social-ecological systems. <em>Sci. Total Environ.</em> <strong>651</strong>, 2105–2117 (2019), https://doi.org/10.1016/j.scitotenv.2018.10.118 Easter Island – Brandt, G. & Merico, A. The slow demise of Easter Island: Insights from a modeling investigation. <em>Front. Ecol. Evol.</em> <strong>3</strong>, 13 (2015), https://www.frontiersin.org/article/10.3389/fevo.2015.00013 Lake phosphorus – Wang, R. <em>et al.</em> Flickering gives early warning signals of a critical transition to a eutrophic lake state. <em>Nature</em> <strong>492</strong>, 419–22 (2012), http://dx.doi.org/10.1038/nature11655 TRIFFID - Ritchie, P. D. L., Clarke, J. J., Cox, P. M. & Huntingford, C. Overshooting tipping point thresholds in a changing climate. <em>Nat. 2021 5927855</em> <strong>592</strong>, 517–523 (2021), http://dx.doi.org/10.1038/nature11655
DOI: 10.5517/ccdc.csd.cc2dpp82
title: CCDC 2225374: Experimental Crystal Structure Determination

description: Related Article: Ahmed Hammouda|2022|CSD Communication|||
description: Related Article: Hamdi A.M. Bennour, Fatin M. Elmagbari, Ahmed N. Hammouda, Rashd M. EL-Ferjani, Younis O. Ben Amer, Saied M. Soliman, Graham E. Jackson|2023|Results in Chemistry|5|100775|doi:10.1016/j.rechem.2023.100775
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.25919/4n72-r307
title: Parkes observations for project P1185 semester 2023APRS_02

description: Ultra-long period neutron stars (ULPNSs) are an emerging class of objects that have sparked interest and curiosity in the fast transient community. Along with standard magnetars, they have been theorised to be potential progenitors of the enigmatic fast radio bursts (FRBs). The MeerTRAP project at the MeerKAT radio telescope is uncovering several magnetar and ultra-long period neutron star candidates, an example of which is PSR J0901-4046 with a period of 76s. Continued long-term monitoring of PSR J0901-4046 has shown it to be potentially transitioning into radio quiescence. The proposed observations will enable us to continue to monitor and characterise the decline in flux density. We have also discovered two new candidates MTP0027 and MTP0068 with periods of ~10 seconds and ~5 seconds respectively. Both sources exhibit magnetar-like pulse morphology and have only been detected in one epoch with MeerKAT. We propose to continue monitoring these sources to re-detect pulses and study their spectro-temporal-polarimetric properties.
DOI: 10.6084/m9.figshare.22919876
title: Metabolome data for alkaline stress in alfalfa roots

description: The metabolome data for alfalfa under alkali stress at different time points.
DOI: 10.6084/m9.figshare.22919876.v2
title: Metabolome data for alkaline stress in alfalfa roots

description: The metabolome data for alfalfa under alkali stress at different time points.
DOI: 10.6084/m9.figshare.22919876.v1
title: Metabolome data.xlsx

description: The metabolome data for alfalfa under alkali stress at different time points.
DOI: 10.6084/m9.figshare.22211595
title: An observational study of safety and clinical outcome measures across patient groups in the United Kingdom Medical Cannabis Registry

description: There is a paucity of high-quality data on patient outcomes and safety after initiating treatment with cannabis-based medicinal products (CBMPs). The aim of this study was to assess the clinical outcomes and safety of CBMPs by analyzing patient-reported outcome measures and adverse events across a broad spectrum of chronic conditions. This study analyzed patients enrolled in the UK Medical Cannabis Registry. Participants completed the EQ-5D-5L to assess health-related quality of life, Generalized Anxiety Disorder-7 (GAD-7) questionnaire to measure anxiety severity, and the Single-item Sleep Quality Scale (SQS) to rate sleep quality at baseline and follow-up after 1, 3, 6, and 12 months. A total of 2833 participants met inclusion criteria. The EQ-5D-5L index value, GAD-7, and SQS all improved at each follow-up (p &lt; 0.001). There was no difference in EQ-5D-5L index values between former or current illicit cannabis consumers and naïve patients (p &gt; 0.050). Adverse events were reported by 474 (16.73%) participants. This study suggests that CBMPs are associated with an improvement in health-related quality of life in UK patients with chronic diseases. Treatment was tolerated well by most participants, but adverse events were more common in female and cannabis-naïve patients.
DOI: 10.6084/m9.figshare.22211595.v1
title: An observational study of safety and clinical outcome measures across patient groups in the United Kingdom Medical Cannabis Registry

description: There is a paucity of high-quality data on patient outcomes and safety after initiating treatment with cannabis-based medicinal products (CBMPs). The aim of this study was to assess the clinical outcomes and safety of CBMPs by analyzing patient-reported outcome measures and adverse events across a broad spectrum of chronic conditions. This study analyzed patients enrolled in the UK Medical Cannabis Registry. Participants completed the EQ-5D-5L to assess health-related quality of life, Generalized Anxiety Disorder-7 (GAD-7) questionnaire to measure anxiety severity, and the Single-item Sleep Quality Scale (SQS) to rate sleep quality at baseline and follow-up after 1, 3, 6, and 12 months. A total of 2833 participants met inclusion criteria. The EQ-5D-5L index value, GAD-7, and SQS all improved at each follow-up (p &lt; 0.001). There was no difference in EQ-5D-5L index values between former or current illicit cannabis consumers and naïve patients (p &gt; 0.050). Adverse events were reported by 474 (16.73%) participants. This study suggests that CBMPs are associated with an improvement in health-related quality of life in UK patients with chronic diseases. Treatment was tolerated well by most participants, but adverse events were more common in female and cannabis-naïve patients.
DOI: 10.6084/m9.figshare.22239426
title: A cost-effectiveness analysis of first-line toripalimab plus chemotherapy in advanced nonsquamous non-small cell lung cancer in China

description: This study compares first-line toripalimab with chemotherapy for advanced nonsquamous non-small cell lung cancer (NSCLC) from the perspective of the Chinese healthcare system. A three-state Markov model was established to compare the quality-adjusted life years (QALYs) and incremental cost-effectiveness ratio (ICER) of first-line toripalimab plus chemotherapy versus chemotherapy. Clinical outcomes data were acquired from the CHOICE-01 clinical trials. Costs and utilities were gathered from regional databases or published publications. One-way sensitivity and probability sensitivity analyses were used to investigate the stability of the model parameters. First-line toripalimab treatment for advanced nonsquamous NSCLC resulted in an incremental cost of $16,214.03 and added 0.77 QALYs compared to chemotherapy, which had an ICER of $21,057.18 per QALY gained. The ICER was substantially lower than the willingness to pay (WTP) threshold in China, which was $37,663.26 per QALY. The toripalimab cycle used was shown to have the greatest impact on the ICERs, according to sensitivity analysis, although none of the factors significantly affected the model’s outcomes Toripalimab plus chemotherapy is likely to be a cost-effective option compared with chemotherapy alone for patients with advanced nonsquamous NSCLC from the perspective of the Chinese healthcare system.
DOI: 10.6084/m9.figshare.22310605
title: First morphological and molecular investigation of the mycobiota associated with <i>Astragalus nebrodensis</i> in its natural environment (Madonie mountains, Sicily)

description: Although <i>Astragalus nebrodensis</i> plays a fundamental ecological role, mycorrhizal fungi associated with this species have never been investigated in natural habitats. Our aim was to check the presence and occurrence of Arbuscular Mycorrhizal Fungi (AMF) in roots of <i>A. nebrodensis</i> in a natural habitat and to screen the fungal diversity in the surrounding soil, considering the positive influence of mycotrophic shrub species on soil microbiota. A morphological analysis was performed on <i>A. nebrodensis</i> roots samples from the Madonie mountains (Sicily, Italy), while high-throughput-sequencing was carried out in <i>A. nebrodensis</i> roots and in the associated soil. Observations of <i>A. nebrodensis</i> roots revealed typical structures of AMF. Sequencing revealed that Ascomycota was the most abundant phylum in both roots and soil samples, followed by Basidiomycota and Mucoromycota. <i>A. nebrodensis</i> roots host a fungal community with lower richness as compared to soil and specific taxa were differentially abundant between roots and soil. The endomycorrhizal symbiosis in <i>A. nebrodensis</i> from a natural habitat is reported here for the first time. The fungal diversity between the two matrices (soil <i>vs</i> roots) supports the notion of a specialised and well-established root microbiome in <i>A. nebrodensis</i> enabling it to survive the stressful conditions of its harsh environment.
DOI: 10.6084/m9.figshare.22310605.v1
title: First morphological and molecular investigation of the mycobiota associated with <i>Astragalus nebrodensis</i> in its natural environment (Madonie mountains, Sicily)

description: Although <i>Astragalus nebrodensis</i> plays a fundamental ecological role, mycorrhizal fungi associated with this species have never been investigated in natural habitats. Our aim was to check the presence and occurrence of Arbuscular Mycorrhizal Fungi (AMF) in roots of <i>A. nebrodensis</i> in a natural habitat and to screen the fungal diversity in the surrounding soil, considering the positive influence of mycotrophic shrub species on soil microbiota. A morphological analysis was performed on <i>A. nebrodensis</i> roots samples from the Madonie mountains (Sicily, Italy), while high-throughput-sequencing was carried out in <i>A. nebrodensis</i> roots and in the associated soil. Observations of <i>A. nebrodensis</i> roots revealed typical structures of AMF. Sequencing revealed that Ascomycota was the most abundant phylum in both roots and soil samples, followed by Basidiomycota and Mucoromycota. <i>A. nebrodensis</i> roots host a fungal community with lower richness as compared to soil and specific taxa were differentially abundant between roots and soil. The endomycorrhizal symbiosis in <i>A. nebrodensis</i> from a natural habitat is reported here for the first time. The fungal diversity between the two matrices (soil <i>vs</i> roots) supports the notion of a specialised and well-established root microbiome in <i>A. nebrodensis</i> enabling it to survive the stressful conditions of its harsh environment.
DOI: 10.6084/m9.figshare.21944871
title: Cytogenetic characterization and chromosome evolution of the striking tropical Andean species of <i>Capsicum</i> (Solanaceae)

description: Fluorochrome chromosome banding and fluorescent <i>in situ</i> hybridization were used to cytogenetically characterize the striking tropical Andean clade species of <i>Capsicum</i>. An adapted dendrogram of the <i>Capsicum</i> phylogeny is presented, showing taxonomic relationships between karyotypes of the Andean clade species, <i>C. baccatum</i> var. <i>pendulum</i>, <i>C. flexuosum</i>, and the sister group <i>Lycianthes</i>. To date, the Andean clade includes nine species: <i>C. dimorphum</i>, <i>C. geminifolium</i>, <i>C. hookerianum</i>, <i>C. lanceolatum</i>, <i>C. longifolium</i>, <i>C. lycianthoides</i>, <i>C. piuranum</i>, <i>C. regale</i> and <i>C. rhomboideum</i>, all displaying 2n = 26. This group is characterized by conspicuous cytogenetic characters that are very useful in the identification of their species and allow them to be distinguished from the other group of species with <i>x</i> = 13 from the Atlantic forest, and definitely from the clades with <i>x</i> = 12. The species of the Andean clade possess relatively short genomes, with one NOR per haploid complement. The distribution of the heterochromatin is mainly subterminal. A single locus of the 35S and 5S rDNA was found per haploid complement. The discovery of three pairs of 5S rDNA sites in <i>C. regale</i> was surprising. The chromosomal features of these highland clade species could be considered adaptive characters to their geographical distribution.
DOI: 10.6084/m9.figshare.21944871.v1
title: Cytogenetic characterization and chromosome evolution of the striking tropical Andean species of <i>Capsicum</i> (Solanaceae)

description: Fluorochrome chromosome banding and fluorescent <i>in situ</i> hybridization were used to cytogenetically characterize the striking tropical Andean clade species of <i>Capsicum</i>. An adapted dendrogram of the <i>Capsicum</i> phylogeny is presented, showing taxonomic relationships between karyotypes of the Andean clade species, <i>C. baccatum</i> var. <i>pendulum</i>, <i>C. flexuosum</i>, and the sister group <i>Lycianthes</i>. To date, the Andean clade includes nine species: <i>C. dimorphum</i>, <i>C. geminifolium</i>, <i>C. hookerianum</i>, <i>C. lanceolatum</i>, <i>C. longifolium</i>, <i>C. lycianthoides</i>, <i>C. piuranum</i>, <i>C. regale</i> and <i>C. rhomboideum</i>, all displaying 2n = 26. This group is characterized by conspicuous cytogenetic characters that are very useful in the identification of their species and allow them to be distinguished from the other group of species with <i>x</i> = 13 from the Atlantic forest, and definitely from the clades with <i>x</i> = 12. The species of the Andean clade possess relatively short genomes, with one NOR per haploid complement. The distribution of the heterochromatin is mainly subterminal. A single locus of the 35S and 5S rDNA was found per haploid complement. The discovery of three pairs of 5S rDNA sites in <i>C. regale</i> was surprising. The chromosomal features of these highland clade species could be considered adaptive characters to their geographical distribution.