cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.5671528.v1
title: The legacy of Cabanis: a hypothesis on the roots of medical education in Brazil

description: Georges Cabanis was a reformer of clinical practice and medical education who laid the conceptual foundations during the French Revolution for the development of education in France over the course of the 19th century. The model, in turn, marked the organization of educational systems in many Latin American countries. The objective of this article is to present and justify a hypothesis: the model of medical education still hegemonic in Brazil is still based upon the Cabanisian reform, holding a linear and Cartesian conceptual perspective, with a discipline-based curriculum, traditional teaching formats, and submission to corporate professional logic. In order to better understand the social and political context of the historical processes that generated this anachronism, I begin with a summary of the biography and thinking of Georges Cabanis, introducing him as a central character in his historical context. Next, I highlight the main structural elements in the Cabanis model, with a special focus on medical teaching, drawing on some of his writings as the documental source. Finally, in broad strokes, I present the project for reform of medical teaching elaborated by Cabanis and his collaborators as backing for a preliminary evaluation of the proposed hypothesis.
DOI: 10.6084/m9.figshare.5671525
title: CY-1/Amine - DSC

description: CY-1/Amine - DSC
DOI: 10.6084/m9.figshare.5671525.v1
title: CY-1/Amine - DSC

description: CY-1/Amine - DSC
DOI: 10.6084/m9.figshare.5671522
title: Vicente Jorge Dias Cabral: a naturalist in the captaincy of Maranhão and Piauí

description: Abstract From late 1799 to early 1803, Vicente Jorge Dias Cabral led a scientific expedition that traversed 16 parishes and 956 leagues through the captaincy of Maranhão and Piauí. Cabral was born in the captaincy of Minas Gerais and studied at the University of Coimbra; in 1789, he graduated in philosophy and, five years later, he graduated from the Faculty of Law. Scientific expeditions, which had been common since the time of the minister Martinho de Mello e Castro (1770-1795), intensified with the appointment of D. Rodrigo de Sousa Coutinho as Secretary of the Navy and Overseas (1795). New and old interests included extraction of saltpeter, introduction of new agricultural products such as cochineal, quinine, and indigo, and an inventory of water resources and channels capable of connecting the captaincies. Vicente Cabral’s expedition produced a variety of records and prepared him to compete for positions in the Portuguese bureaucracy. This article explores Vicente Cabral’s scientific expedition and the possibilities opened to him through appointments that subsequently allowed him to join the ranks of the learned who occupied these positions.
DOI: 10.6084/m9.figshare.5671522.v1
title: Vicente Jorge Dias Cabral: a naturalist in the captaincy of Maranhão and Piauí

description: Abstract From late 1799 to early 1803, Vicente Jorge Dias Cabral led a scientific expedition that traversed 16 parishes and 956 leagues through the captaincy of Maranhão and Piauí. Cabral was born in the captaincy of Minas Gerais and studied at the University of Coimbra; in 1789, he graduated in philosophy and, five years later, he graduated from the Faculty of Law. Scientific expeditions, which had been common since the time of the minister Martinho de Mello e Castro (1770-1795), intensified with the appointment of D. Rodrigo de Sousa Coutinho as Secretary of the Navy and Overseas (1795). New and old interests included extraction of saltpeter, introduction of new agricultural products such as cochineal, quinine, and indigo, and an inventory of water resources and channels capable of connecting the captaincies. Vicente Cabral’s expedition produced a variety of records and prepared him to compete for positions in the Portuguese bureaucracy. This article explores Vicente Cabral’s scientific expedition and the possibilities opened to him through appointments that subsequently allowed him to join the ranks of the learned who occupied these positions.
DOI: 10.6084/m9.figshare.5671519
title: Archaeological illustration in the Andes (1850-1890)

description: Abstract In broad terms, European publications on the Andes allow one to trace a historical trajectory over the course of four centuries, from a system of representation that is intimately tethered – and subsidiary – to the written word, to one where the images become the raison d’être of publication. This trajectory mirrors the field of archaeology itself, from its origins in an antiquarian tradition dominated by philological concerns in the sixteenth and seventeenth centuries, to the nineteenth century, when evidence becomes less about words, and more about pictures. This paper focuses on the peak of this trajectory: archaeological atlases created between 1850 and 1890, particularly the work of Wilhelm Reiss and Alphons Stübel and their three-volume publication, “The necropolis of Ancon in Peru”. The present study analyzes the role of archaeological illustration in illuminating, disseminating, and understanding a pre-Inca past in the nineteenth century, and ultimately how images shape the construction of knowledge.
DOI: 10.6084/m9.figshare.5671519.v1
title: Archaeological illustration in the Andes (1850-1890)

description: Abstract In broad terms, European publications on the Andes allow one to trace a historical trajectory over the course of four centuries, from a system of representation that is intimately tethered – and subsidiary – to the written word, to one where the images become the raison d’être of publication. This trajectory mirrors the field of archaeology itself, from its origins in an antiquarian tradition dominated by philological concerns in the sixteenth and seventeenth centuries, to the nineteenth century, when evidence becomes less about words, and more about pictures. This paper focuses on the peak of this trajectory: archaeological atlases created between 1850 and 1890, particularly the work of Wilhelm Reiss and Alphons Stübel and their three-volume publication, “The necropolis of Ancon in Peru”. The present study analyzes the role of archaeological illustration in illuminating, disseminating, and understanding a pre-Inca past in the nineteenth century, and ultimately how images shape the construction of knowledge.
DOI: 10.6084/m9.figshare.5671513
title: The Diterpene Sclareol Vascular Effect in Normotensive and Hypertensive Rats

description: Abstract Background: The diterpene Sclareol has antimicrobial action, cytotoxic and cytostatic effects and anti-tumor activities. However, researches on the cardiovascular system are scarce. Objective: This study was designed to investigate the mechanisms involved in the Sclareol cardiovascular effect in normotensive and hypertensive rats. Methods: The arterial hypertension was promoted using 2-kidneys 1-clip model in rats. The effect of sclareol on blood pressure was performed by using three dose (10, 20 and 40 mg/kg). Cumulative dose-response curves for Sclareol were determined for endothelium-intact and endothelium-denuded aortic rings in presence or absence of L-NAME and ODQ. The NOx levels were measure in the plasma sample. Results: The Sclareol administration in vivo caused a significant reduction in blood pressure in both groups. In vitro the sclareol promoted relaxation in aorta, with endothelium, pre-contracted to Phe. The inhibitors of the nitric oxide synthase and soluble guanylate cyclase were as efficient as the removal of endothelium, in inhibiting the Sclareol-induced relaxation. Otherwise, it was no change of NOx. Also, for unknown reasons, the Sclareol is not selective for hypertensive animals. Conclusion: The diterpene Sclareol showed in vivo hypotensive and in-vitro vasodilator effects; The chemiluminescence plasmatic NO analysis showed no significant difference between groups and The Sclareol exhibit better effect on normotensive than hypertensive animals to reduce blood pressure. It is concluded that the diterpenes metabolites would be a promising source prototype for the development of new agents in the cardiovascular therapy.
DOI: 10.6084/m9.figshare.5671513.v1
title: The Diterpene Sclareol Vascular Effect in Normotensive and Hypertensive Rats

description: Abstract Background: The diterpene Sclareol has antimicrobial action, cytotoxic and cytostatic effects and anti-tumor activities. However, researches on the cardiovascular system are scarce. Objective: This study was designed to investigate the mechanisms involved in the Sclareol cardiovascular effect in normotensive and hypertensive rats. Methods: The arterial hypertension was promoted using 2-kidneys 1-clip model in rats. The effect of sclareol on blood pressure was performed by using three dose (10, 20 and 40 mg/kg). Cumulative dose-response curves for Sclareol were determined for endothelium-intact and endothelium-denuded aortic rings in presence or absence of L-NAME and ODQ. The NOx levels were measure in the plasma sample. Results: The Sclareol administration in vivo caused a significant reduction in blood pressure in both groups. In vitro the sclareol promoted relaxation in aorta, with endothelium, pre-contracted to Phe. The inhibitors of the nitric oxide synthase and soluble guanylate cyclase were as efficient as the removal of endothelium, in inhibiting the Sclareol-induced relaxation. Otherwise, it was no change of NOx. Also, for unknown reasons, the Sclareol is not selective for hypertensive animals. Conclusion: The diterpene Sclareol showed in vivo hypotensive and in-vitro vasodilator effects; The chemiluminescence plasmatic NO analysis showed no significant difference between groups and The Sclareol exhibit better effect on normotensive than hypertensive animals to reduce blood pressure. It is concluded that the diterpenes metabolites would be a promising source prototype for the development of new agents in the cardiovascular therapy.
DOI: 10.6084/m9.figshare.5671510
title: Peripheral Vascular Resistance Impairment during Isometric Physical Exercise in Normotensive Offspring of Hypertensive Parents

description: Abstract Background: A family history of hypertension is associated with vascular and autonomic abnormalities, as well as an impaired neurohemodynamic response to exercise. Objective: To test the hypothesis that normotensive individuals with a family history of hypertension present an impaired peripheral vascular resistance response to exercise. Methods: The study included 37 normotensive volunteers of both sexes who were sedentary, eutrophic, and nonsmokers, comprising 23 with (FH+; 24 ± 3 years) and 14 without (FH-; 27 ± 5 years) a family history of hypertension. Blood pressure, heart rate (DIXTAL®), forearm blood flow (Hokanson®), and peripheral vascular resistance were simultaneously measured for 3 minutes during rest and, subsequently, for 3 minutes during an isometric exercise at 30% of maximal voluntary contraction (Jamar®). Results: At rest, the FH+ and FH- groups present similar mean blood pressure (83 ± 7 versus 83 ± 5 mmHg, p = 0.96), heart rate (69 ± 8 bpm versus 66 ± 7 bpm, p = 0.18), forearm blood flow (3 ± 1 mL/min/100 mL versus 2.7 ± 1 mL/min/100 mL, p = 0.16), and peripheral vascular resistance (30 ± 9 units versus 34±9 units, p = 0.21), respectively. Both groups showed a significant and similar increase in mean blood pressure (∆ = 15 ± 7 mmHg versus 14 ± 7 mmHg, p = 0.86), heart rate (∆ = 12 ± 8 bpm versus 13 ± 7 bpm, p = 0.86), and forearm blood flow (∆ = 0.8 ± 1.2 mL/min/100 mL versus 1.4 ± 1.1 mL/min/100 mL, p = 0.25), respectively, during exercise. However, individuals in the FH+ group showed no reduction in peripheral vascular resistance during exercise, which was observed in the FH- group (∆ = -0.4 ± 8.6 units versus -7.2 ± 6.3 units, p = 0.03). Conclusion: Normotensive individuals with a family history of hypertension present an impaired peripheral vascular resistance response to exercise.
DOI: 10.6084/m9.figshare.5671510.v1
title: Peripheral Vascular Resistance Impairment during Isometric Physical Exercise in Normotensive Offspring of Hypertensive Parents

description: Abstract Background: A family history of hypertension is associated with vascular and autonomic abnormalities, as well as an impaired neurohemodynamic response to exercise. Objective: To test the hypothesis that normotensive individuals with a family history of hypertension present an impaired peripheral vascular resistance response to exercise. Methods: The study included 37 normotensive volunteers of both sexes who were sedentary, eutrophic, and nonsmokers, comprising 23 with (FH+; 24 ± 3 years) and 14 without (FH-; 27 ± 5 years) a family history of hypertension. Blood pressure, heart rate (DIXTAL®), forearm blood flow (Hokanson®), and peripheral vascular resistance were simultaneously measured for 3 minutes during rest and, subsequently, for 3 minutes during an isometric exercise at 30% of maximal voluntary contraction (Jamar®). Results: At rest, the FH+ and FH- groups present similar mean blood pressure (83 ± 7 versus 83 ± 5 mmHg, p = 0.96), heart rate (69 ± 8 bpm versus 66 ± 7 bpm, p = 0.18), forearm blood flow (3 ± 1 mL/min/100 mL versus 2.7 ± 1 mL/min/100 mL, p = 0.16), and peripheral vascular resistance (30 ± 9 units versus 34±9 units, p = 0.21), respectively. Both groups showed a significant and similar increase in mean blood pressure (∆ = 15 ± 7 mmHg versus 14 ± 7 mmHg, p = 0.86), heart rate (∆ = 12 ± 8 bpm versus 13 ± 7 bpm, p = 0.86), and forearm blood flow (∆ = 0.8 ± 1.2 mL/min/100 mL versus 1.4 ± 1.1 mL/min/100 mL, p = 0.25), respectively, during exercise. However, individuals in the FH+ group showed no reduction in peripheral vascular resistance during exercise, which was observed in the FH- group (∆ = -0.4 ± 8.6 units versus -7.2 ± 6.3 units, p = 0.03). Conclusion: Normotensive individuals with a family history of hypertension present an impaired peripheral vascular resistance response to exercise.
DOI: 10.6084/m9.figshare.5671507
title: Hybrid composites reinforced with short sisal fibres and micro ceramic particles

description: ABSTRACT Biocomposites reinforced with natural fibres have been extensively investigated as a promising replacing material for synthetic ones, such as the glass fibre reinforced composites. The length of natural fibres depends not only on the plant species, but also on the extraction processing. The heterogeneity of natural fibres, in terms of length, can be considered a problem for some industrial applications. A little amount of work has been conducted towards the use of short natural fibres in composite materials. In order to balance the reduction of strength due to the use of short length fibres, ceramic particles can be incorporated. This paper describes the experimental characterization of hybrid biocomposites consisted of epoxy polymer, short random sisal fibres and Portland cement particles. A full factorial design was performed to investigate the effect of the factors and levels, such as fibre length (4 mm and 8 mm) and Portland cement inclusion (0wt%, 5wt% and 10wt%) on the following properties, flexural modulus and strength (via three-point bending test), damping ratio, apparent porosity and water absorption. The fibre volume fraction was kept constant at 25%. The Design of Experiment (DoE) analysis revealed the “Fibre length” factor does not affect the responses. The interaction “Fibre length and Cement inclusion” affected only the stiffness. Portland cement particles statistically revealed a noticeable contribution to the apparent porosity and water absorption. The presence of cement particles at 5wt% provided not only the increase in the damping ratio response, but also the reduction in the flexural strength and stiffness.
DOI: 10.6084/m9.figshare.5671507.v1
title: Hybrid composites reinforced with short sisal fibres and micro ceramic particles

description: ABSTRACT Biocomposites reinforced with natural fibres have been extensively investigated as a promising replacing material for synthetic ones, such as the glass fibre reinforced composites. The length of natural fibres depends not only on the plant species, but also on the extraction processing. The heterogeneity of natural fibres, in terms of length, can be considered a problem for some industrial applications. A little amount of work has been conducted towards the use of short natural fibres in composite materials. In order to balance the reduction of strength due to the use of short length fibres, ceramic particles can be incorporated. This paper describes the experimental characterization of hybrid biocomposites consisted of epoxy polymer, short random sisal fibres and Portland cement particles. A full factorial design was performed to investigate the effect of the factors and levels, such as fibre length (4 mm and 8 mm) and Portland cement inclusion (0wt%, 5wt% and 10wt%) on the following properties, flexural modulus and strength (via three-point bending test), damping ratio, apparent porosity and water absorption. The fibre volume fraction was kept constant at 25%. The Design of Experiment (DoE) analysis revealed the “Fibre length” factor does not affect the responses. The interaction “Fibre length and Cement inclusion” affected only the stiffness. Portland cement particles statistically revealed a noticeable contribution to the apparent porosity and water absorption. The presence of cement particles at 5wt% provided not only the increase in the damping ratio response, but also the reduction in the flexural strength and stiffness.
DOI: 10.6084/m9.figshare.5671504
title: PHBV/cellulose nanofibrils composites obtained by solution casting and electrospinning process

description: ABSTRACT In this work, nanobiocomposites of poly (3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) reinforced with cellulose nanofibrils (CNFs) were produced by electrospinning and solution casting process. CNFs were obtained by sulfuric acid hydrolysis from Imperata brasiliensis fibers. Nanocomposites loaded with 1 (wt. %) of CNFs were prepared using a mixture of solvents chloroform (CHCl3): N, N-dimethylformamide (DMF), in the ratio of 78:22 with 30 h of solubilization. Films by solution casting were obtained in a petri dish, at 50 °C for 1 hour, using drying casting temperature of 153 °C. Mats by electrospinning were obtained with a needle 20x10, drum collector rotation 27 rpm, and working distance of 10 cm. Films and mats were characterized by Scanning Electron Microscopy (SEM), X-ray diffraction (XRD) and Differential Scanning Calorimetry (DSC). It was possible to conclude that for nanobiocomposites obtained by solution casting, the addition of CNFs did not affect the transparency of the films, but provided a significant increase in the crystallization rate as observed by DSC analysis, while for electrospinning nanobiocomposites a considerable improvement in process increasing electrospinning time and quality of the mats manufactured, were observed.
DOI: 10.6084/m9.figshare.5671504.v1
title: PHBV/cellulose nanofibrils composites obtained by solution casting and electrospinning process

description: ABSTRACT In this work, nanobiocomposites of poly (3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) reinforced with cellulose nanofibrils (CNFs) were produced by electrospinning and solution casting process. CNFs were obtained by sulfuric acid hydrolysis from Imperata brasiliensis fibers. Nanocomposites loaded with 1 (wt. %) of CNFs were prepared using a mixture of solvents chloroform (CHCl3): N, N-dimethylformamide (DMF), in the ratio of 78:22 with 30 h of solubilization. Films by solution casting were obtained in a petri dish, at 50 °C for 1 hour, using drying casting temperature of 153 °C. Mats by electrospinning were obtained with a needle 20x10, drum collector rotation 27 rpm, and working distance of 10 cm. Films and mats were characterized by Scanning Electron Microscopy (SEM), X-ray diffraction (XRD) and Differential Scanning Calorimetry (DSC). It was possible to conclude that for nanobiocomposites obtained by solution casting, the addition of CNFs did not affect the transparency of the films, but provided a significant increase in the crystallization rate as observed by DSC analysis, while for electrospinning nanobiocomposites a considerable improvement in process increasing electrospinning time and quality of the mats manufactured, were observed.
DOI: 10.6084/m9.figshare.5671501
title: Mechanical behaviour of steel fiber reinforced concrete with stone powder

description: ABSTRACT Nowadays, there is an increasing interest in the development of eco-friendly materials. Thus, environmental challenges due to the necessity of reducing worldwide levels of CO2 emissions, to limit the energy consumption and to use industrial waste are promoting an increasing effort to find viable alternatives to minimize pollution from the main productive processes. Thus, this paper addresses the results of an investigation on the influence of stone powder, residue from the production of crushed aggregates, on the mechanical performance of concrete reinforced with steel fibers. The effect of the amount of stone powder sand was evaluated using 0%, 50% and 100% natural sand replacement. Workability and mechanical properties were evaluated by compressive, elastic modulus, four-point bending and abrasion tests. Economic impact study of the composite production was also carried out. Based on the results obtained, it is possible to conclude that the use of crushed stone sand in steel fiber reinforced concrete is beneficial in terms of the workability and abrasion resistance but was some disadvantages. For instance, when 100% manufactured sand was added, the compressive and bending strength was reduced. However, the elastic modulus was not changed. It is also important to highlight that with 100% stone powder content, the compressive strength is still higher than 30MPa and the cost for producing is about of 32% cheaper.
DOI: 10.6084/m9.figshare.5671501.v1
title: Mechanical behaviour of steel fiber reinforced concrete with stone powder

description: ABSTRACT Nowadays, there is an increasing interest in the development of eco-friendly materials. Thus, environmental challenges due to the necessity of reducing worldwide levels of CO2 emissions, to limit the energy consumption and to use industrial waste are promoting an increasing effort to find viable alternatives to minimize pollution from the main productive processes. Thus, this paper addresses the results of an investigation on the influence of stone powder, residue from the production of crushed aggregates, on the mechanical performance of concrete reinforced with steel fibers. The effect of the amount of stone powder sand was evaluated using 0%, 50% and 100% natural sand replacement. Workability and mechanical properties were evaluated by compressive, elastic modulus, four-point bending and abrasion tests. Economic impact study of the composite production was also carried out. Based on the results obtained, it is possible to conclude that the use of crushed stone sand in steel fiber reinforced concrete is beneficial in terms of the workability and abrasion resistance but was some disadvantages. For instance, when 100% manufactured sand was added, the compressive and bending strength was reduced. However, the elastic modulus was not changed. It is also important to highlight that with 100% stone powder content, the compressive strength is still higher than 30MPa and the cost for producing is about of 32% cheaper.