cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.23936079
title: Supplementary Material for: TGF-β1 inhibition of ACE2 mediated by miRNA uncovers novel mechanism of SARS-CoV-2 pathogenesis.

description: SARS-CoV-2 utilizes receptor binding domain (RBD) of spike glycoprotein to interact with angiotensin-converting enzyme 2 (ACE2). Decreased cell surface density of ACE2 contributes to mortality during COVID-19. Studies published early during the pandemic reported that people with cystic fibrosis (PwCF) treated with the high efficiency CFTR modulators ETI (elexacaftor-tezacaftor-ivacaftor) had higher ACE2 levels and milder COVID-19 symptoms, compared to people without CF. Subsequent studies did not confirm these findings. TGF-β1 gene polymorphisms associated with higher TGF-β1 levels, present in approximately 40% of CF patients, lead to more severe CF lung disease. To understand whether TGF-β1 modulates COVID-19 severity by affecting ACE2 levels in the airway, we performed small RNAseq and microRNA profiling and identified pathways uniquely affected by TGF-β1, including those associated with SARS-CoV-2 invasion. TGF-β1 inhibited ACE2 expression by miR-136-3p and miR-369-5p. ACE2 levels were higher in CF bronchial epithelial cell models. ETI did not prevent TGF-β1 inhibition of ACE2. Finally, TGF-β1 reduced the interaction between ACE2 and RBD by lowering ACE2 levels and its binding to RBD. Our data demonstrate novel mechanism whereby TGF-β1 inhibition of ACE2 in CF and non-CF bronchial epithelia may modulate SARS-CoV-2 pathogenicity and COVID-19 severity. By reducing ACE2 levels, TGF-β1 may decrease entry of SARS-CoV-2 into host cells while hindering recovery from COVID-19 due to loss of anti-inflammatory effects of ACE2.
DOI: 10.6084/m9.figshare.23963391
title: Supplementary Material for: Association Between Physical Frailty and Sleep Disturbances Among Patients on Hemodialysis: A Cross-sectional Study

description: Introduction Among patients on hemodialysis (HD), physical frailty and sleep disturbances are not only common but also associated with adverse outcomes. The aim of this study was to evaluate the association between physical frailty and sleep disturbances in patients on HD. Methods This cross-sectional study was conducted from June 2017 to March 2021, with outpatients receiving HD thrice a week at two dialysis facilities in Japan. Sleep disturbances were identified with the Athens Insomnia Scale (AIS). Physical frailty was defined using the Fried Frailty Phenotype. Patients were classified as “non-frailty (number of frailty components: 0–2)” or “frailty (3–5).” We examined the association of sleep disturbances with physical frailty and its components by performing a logistic regression analysis. Results We analyzed 360 patients (mean age 65.6 years; 62% men). Eighty-one patients (23%) were classified into the group with frailty, and the mean AIS score was 5.2±4.2points. After adjusting for clinical characteristics, increasing the AIS score per 1 point was associated with higher odds of physical frailty (odds ratio, 1.12; 95% confidence interval, 1.05–1.20; p &lt; 0.01). As for the frailty components, exhaustion, low physical activity, and weak grip strength showed an association with sleep disturbances (all p &lt; 0.05). Conclusions Sleep disturbances were independently associated with physical frailty in patients on HD. Future studies are warranted to investigate the causality between physical frailty and sleep disturbances in this population.
DOI: 10.6084/m9.figshare.23974377
title: Supplementary Material for: Safety of Tigecycline in Patients on Antithrombotic Therapy: A Single Center Retrospective Study

description: Introduction: To investigate the risk factors of tigecycline-induced hypofibrinogenemia, and to evaluate the safety of tigecycline with concomitant antithrombotic drugs. Methods: We performed a retrospective analysis of patients who received tigecycline for more than 3 days between January 2015 and June 2019. Clinical and laboratory data were collected including fibrinogen concertation, tigecycline dose, duration of treatment, disease severity, complete blood count, indicators of infection, liver and renal function. Risk factors of hypofibrinogenemia were analyzed by univariate and multivariate analysis. To evaluate the safety of tigecycline and concomitant antithrombotic drugs, bleeding events were assessed by comparing the decline in hemoglobin and the amount of red blood cell transfusion in patients with antithrombotic drugs and those without. Results: This study included a total of 68 cases, 20 of which experienced hypofibrinogenemia while receiving tigecycline treatment. Duration of treatment, cefoperazone/sulbactam combination therapy, and fibrinogen levels prior to initiation of tigecycline were risk factors associated with tigecycline-induced hypofibrinogenemia. There were 26 recorded bleeding incidents, 25 of which happened before the start of tigecycline. Antithrombotic and non-antithrombotic patients did not differ in their hemoglobin decline or need for red blood cell transfusions while taking tigecycline. Conclusion: A longer treatment duration, cefoperazone/sulbactam combination therapy, and a lower level of fibrinogen level before tigecycline were associated with an increased risk of tigecycline induced hypofibrinogenemia. A combination of antithrombotic drugs and tigecycline did not aggravate the bleeding events during tigecycline treatment.
DOI: 10.6084/m9.figshare.23996679
title: Supplementary Material for: Factors influencing genetic screening enrollment among a diverse, community-ascertained cohort

description: Introduction: Genetic screening for preventable adult-onset hereditary conditions has been proposed as a mechanism to reduce health disparities. Analysis of how race and ethnicity influence decision-making to receive screening can inform recruitment efforts and more equitable population screening design. A study at the University of Washington Medicine that invited unselected patients to participate in genetic screening for pathogenic variation in medically important genes provided an opportunity to evaluate these factors. Methods: We analyzed screening enrollee survey data to understand factors most important and least important in decision-making about screening overall and across different race and ethnicity groups. Electronic health record race and ethnicity and survey-reported race and ethnicity were compared to assist with interpretation. Comments provided about reasons for not enrolling in screening were analyzed using content analysis. Results: Overall, learning about disease risk and identifying risk early for prevention purposes were important factors in decision-making to receive screening and regrets about screening and screening being against one’s moral code were not viewed as important. Although racial identity was challenging to assign in all cases, compared to other enrollees, African American and Asian enrollees considered test accuracy and knowing more about the test to be of greater importance. Three themes emerged related to nonparticipation: benefits do not outweigh risks, don’t want to know, and challenges with study logistics. Conclusion: Our results highlight important motivators for receiving screening and areas that can be addressed to increase screening interest and accessibility. This knowledge can inform future population screening program design including recruitment and education approaches.
DOI: 10.6084/m9.figshare.24099420
title: Supplementary Material for: A Randomized, Double-Blind, Placebo-Controlled, Multicenter, 16-Week Trial to Evaluate the Efficacy and Safety of FB-401 in Children, Adolescent and Adult Subjects (Ages 2 Years and Older) with Mild to Moderate Atopic Dermatitis

description: Background: Atopic dermatitis is a common chronic, relapsing and remitting inflammatory skin disorder associated with cutaneous dysbiosis. Current treatment options often fail to adequately control the disease and have unfavorable safety profiles. There is a need for new options that address these treatment shortcomings. Objective: To evaluate the efficacy, safety, and tolerability of FB-401, a live therapeutic product of 3 strains of Roseomonas mucosa, compared to matching placebo applied topically 3 times per week to participants ages ≥ 2 years of age with mild to moderate atopic dermatitis. Methods: A randomized, double-blind, placebo-controlled, parallel-group study. The primary outcome was the proportion of participants with 50% improvement in Eczema Area and Severity Index score from baseline at week 16. 154 subjects aged 2 or older with a clinical diagnosis of atopic dermatitis as defined by Hanifin and Rajka criteria with mild or moderate severity were randomized 1:1 via Interactive Web Response System to FB-401 or placebo. Results: The proportion of subjects who achieved the primary outcome was similar between both treatment groups, with no significant treatment group differences observed at any post-baseline visit. The number of treatment emergent adverse events and the number of subjects with at least one was similar across treatment groups. One serious adverse event not related to treatment was reported. No treatment emergent adverse events led to treatment discontinuation or study discontinuation. Conclusions: FB-401 showed an acceptable safety profile, but failed to prove superior to placebo in treating children and adults with mild to moderate atopic dermatitis.
DOI: 10.6084/m9.figshare.24105228
title: Supplementary Material for: Synchronous urinary bladder urothelial carcinoma and transitional cell carcinoma of the ovary: case report

description: Transitional cell carcinoma (TCC) of ovary is a rare subtype of epithelial ovarian tumours defined as a tumour composed of epithelial elements histologically resembling urothelium and its neoplasms. Ovarian metastases from primary urinary tract carcinomas are rare. The differential diagnosis of primary transitional cell carcinoma (TCC) of the ovary versus metastatic bladder TCC is challenging because of histological similarity. We present the case of a 49-year-old premenopausal woman who was initially diagnosed with non-invasive papillary urothelial carcinoma of bladder (NIPUC) and after two years with a synchronous TCC of the ovary while being investigated for suspected relapse. She underwent a radical cystectomy, total hysterectomy, bilateral salpingo-oopharectomy and pelvic lymph node dissection. The final diagnosis of synchronous NIPUC of the bladder and TCC of the ovary was made by histopathology and immunohistochemical studies (IHC).
DOI: 10.6084/m9.figshare.24131049
title: Supplementary Material for: Life of the B10 mouse: a view from the hair follicles and tissue stem cells

description: In our series of studies, the changes in the skin characteristics of mice caused by aging were investigated in correlation with the stem cells for keratinocytes and melanocytes in the natural hair cycle until middle age. The aim of the present review was to investigate these characteristics of hair follicles (HFs) at older age and complete the analysis of these changes as a study throughout the mouse lifetime. In addition, stem cells for keratinocytes and melanocytes were evaluated for changes in skin characteristics caused by aging. Postnatal day 200 (P200) appears to be the age of complete maturation of skin and the onset of aging with regard to HFs. Keratin 15-positive keratinocyte stem cells complete their localization as a quantitatively sufficient amount of progenitor in the hair bulge region and orchestrate the regeneration of hairs in every anagen phase thereafter. Although their frequency is low, an unusual structure of HFs, curved HFs, appear for the first time at P200. Thereafter, abnormal hair curvature continues to increase throughout life. In contrast, HF characteristics derived from melanocytes begin to show a high frequency of hypopigmented hair bulbs at P200 and appear to lead to a significant increase in the number of white hairs. Curved HFs and white hairs were considered biomarkers of aging in mice. The number of tyrosinase-related protein 2-positive melanocyte stem cells in the hair bulge is extremely low and may be one cause underlying not only the induction of melanocyte-derived characteristics by aging but possibly also that of keratinocyte-derived characteristics. These results provide insight into the mechanisms of the actions of stem cells on hair regeneration through the aging process.
DOI: 10.6084/m9.figshare.24145479
title: Supplementary Material for: Effective Management of Nasal Vestibule Squamous Cell Carcinoma with Cemiplimab: A Case Report

description: Nasal vestibule squamous cell carcinoma (SCC) is a rare malignancy with limited treatment options. This case report presents an 83-year-old female with SCC of the nasal vestibule who was ineligible for surgery or radiotherapy due to various factors. The patient was successfully treated with cemiplimab, a systemic anti-PD-1 antibody, resulting in a remarkable tumor reduction without any observed side effects. This is the first reported case of nasal vestibule SCC treated with cemiplimab, highlighting its potential as a promising therapeutic option
DOI: 10.6084/m9.figshare.24205305
title: Supplementary Material for: Miliary tuberculosis during R-MPV therapy in an elderly patient with primary central nerve system lymphoma: a case report

description: Most elderly patients with tuberculosis (TB) have previously been infected with Mycobacterium tuberculosis, which remains dormant in the body for decades and may reactivate when their immunity declines due to underlying diseases. Elderly cancer patients are at a high risk for TB, and the treatment of TB reactivation in these patients is challenging. Among cancer patients, the incidence of TB reactivation is the highest in lymphoma patients. However, the impact of chemotherapy on TB reactivation in lymphoma patients is unknown. We report the case of an immunocompetent elderly patient with primary central nervous system lymphoma (PCNSL) having no prior history of TB, who developed miliary TB during multiagent chemotherapy consisting of rituximab, high-dose methotrexate, procarbazine, and vincristine (R-MPV therapy). Retrospectively, the chest CT showed calcification of the pleura, suggesting that the patient had a latent tuberculosis infection (LTBI) and developed miliary TB from the reactivation of TB triggered by the R-MPV therapy. Our case emphasizes that when chemotherapy is administered to patients with PCNSL, interferon-gamma release assay (IGRA) should be performed if there are findings on chest examination suggestive of LTBI, such as pleural calcification, and if IGRA is positive, chemotherapy should be given concurrently with LTBI treatment.
DOI: 10.17189/1520220
title: MER 1 MARS PANCAM RADIOMETRICALLY CALIBRATED RDR V1.0
DOI: 10.17632/kwcvfr52hp.4
title: Atlantic extratropical cyclone tracks in 41 years of ERA5 and CFSR/CFSv2 databases

description: Main reference: Gramcianinov, C.B., Campos, R.M., de Camargo, R., Hodges, K.I., Guedes Soares, C., da Silva Dias, P.L., 2020. "Analysis of Atlantic extratropical storm tracks characteristics in 41 years of ERA5 and CFSR/CFSv2 databases", Ocean Engineering 216C, 108111. https://doi.org/10.1016/j.oceaneng.2020.108111 Please read the README.txt file for further details. This database is in continuous development. To report an error, make suggestions or questions, please contact cbgramcianinov@gmail.com. *v3: added the README file and updated the main reference. *v4: added missing files (ff_cyc_ExSAt_era5_198308, ff_cyc_ExSAt_era5_201908) Acknowledgement: Project “Extreme wind and wave modelling and statistics in the Atlantic Ocean” (EXWAV) financed by the Portuguese Foundation for Science and Technology (Fundação para a Ciência e Tecnologia-FCT) under contract PTDC/EAM-OCE/31325/2017 RD0504, and by the São Paulo Research Foundation (Fundação de Amparo à Pesquisa do Estado de São Paulo - FAPESP) grant 2018/08057-5.
DOI: 10.17632/zvcc9gvys9.1
title: Cultural differences in the measurement of self-curiosity within Mexico: a person-centered and variable-centered study

description: Background: This study assessed the role of culture in the measurement of the Self-Curiosity Attitude-Interest scale (SCAI-M), a measure of attitude and interest in increasing one’s knowledge of self, adopting both a person-centered and variable-centered approach. 
Methods: The study was conducted on a Mexican sample composed of 484 adult participants who completed both the SCAI-M and a series of instruments that measure cultural dimensions thought Qualtrix. Data were collected between November 9, 2020 to December 18, 2020, and respondents were contacted using advertisements on social media platforms (Facebook and WhatsApp). Analyses included multigroup confirmatory factor analysis and latent profile analysis.
Results: A latent profile analysis allowed for the generation of three groups featuring distinct cultural orientations that were similar to previously found cultural profiles (Consensus-oriented Egalitarians, Flexible Individualists, and Rules-based Competitors). Multigroup Confirmative Factor Analysis showed partial metric and scalar invariance for the SCAI-M between groups; moreover, we found proofs of convergent validity with other cultural dimensions besides the ones linked with the Hofstede model. Our results indicate that cultural profiles and cultural variables are associated with both the level and meaning of self-curiosity among Mexican citizens. 
Conclusions: Finally, the discussion includes considerations on self-curiosity divergence among minority cultures and relevant clinical applications; a field for which we propose future research.
DOI: 10.5066/f7gf0rn2
title: Tables and charts for isotope-abundance variations and atomic weights of selected elements: 2016

description: There are 63 chemical elements that have two or more isotopes that are used to determine their standard atomic weights. The isotopic abundances and atomic weights of these elements can vary in normal materials due to physical and chemical fractionation processes (not due to radioactive decay). These variations are well known for 12 elements (hydrogen, lithium, boron, carbon, nitrogen, oxygen, magnesium, silicon, sulfur, chlorine, bromine and thallium), and the standard atomic weight of each of these elements is given by IUPAC (International Union of Pure and Applied Chemistry) as an interval with a lower and upper bounds. Graphical plots of selected materials and compounds of each of these elements have been published previously, and herein isotopic abundances, isotope-delta values, and atomic weights for each of the upper and lower bounds of these materials and compounds are provided. Charts showing the variations in selected materials for each element are also provided.
DOI: 10.5281/zenodo.7752545
title: The underlying radial acceleration relation -- supplementary data

description: Supplementary data and plots associated with "The underlying radial acceleration relation", Desmond (2023). See the README for further information.
description: HD is supported by a Royal Society University Research Fellowship (grant no. 211046).
DOI: 10.6084/m9.figshare.23791494
title: Supplementary Material for: Apalutamide-induced toxic epidermal necrolysis in a Caucasian patient with metastatic castration-sensitive prostate cancer: a case report and review of the literature

description: Apalutamide is a novel nonsteroidal androgen receptor inhibitor that has been shown to improve outcomes for patients with nonmetastatic castration-resistant prostate cancer and metastatic castration-sensitive prostate cancer when combined with androgen deprivation therapy. Apalutamide-induced skin rash occurred commonly in clinical trials, with 23.8-27.1% of patients experiencing a rash of any grade, and 5.2-6.3% experiencing a rash of grade three or higher. There were no cases of severe cutaneous adverse events (SCARs) such as Stevens-Johnson syndrome (SJS) or toxic epidermal necrolysis (TEN) reported in clinical trials, however there are rare cases reported in the literature with the majority occurring in Asian patients. An 83-year-old Caucasian male was commenced on apalutamide, combined with degarelix, for the management of metastatic castration-sensitive prostate cancer. During week five of apalutamide treatment, the patient developed a widespread erythematous maculopapular rash. On presentation, the rash affected 80% of his body surface area (BSA) and a diagnosis of a severe cutaneous drug eruption was made. He was commenced on methylprednisolone (MP) therapy. Despite five days of MP, the rash continued to deteriorate involving 95% of his BSA. Nikolsky’s sign was positive. A diagnosis of overlap SJS/TEN was made, supported by skin biopsy. His SCORTEN score was three. He was then commenced on intravenous immunoglobulin and transferred to the intensive care unit. Over the coming days, the rash began to stabilise, and his steroid dose was weaned. He was discharged from hospital 38 days after rash onset. We report the first suggested case of apalutamide-induced SJS/TEN in a Caucasian patient. We discuss other cases of apalutamide-induced SCARs reported in the literature. Risk factors seem to include low body weight and Japanese race, as well as short time to onset of rash.
DOI: 10.6084/m9.figshare.23947131
title: Supplementary Material for: Successful treatment with osimertinib based on therapeutic drug monitoring in a hemodialysis patient with non-small cell lung cancer: a case report

description: Although osimertinib is a key drug in the treatment of non-small cell lung cancer (NSCLC) with epidermal growth factor receptor (EGFR) mutation, the safety in hemodialysis patients has not been established. A 76-year-old man was diagnosed with NSCLC with EGFR deletion mutation in exon 19. After treatment failure with first- and second-generation EGFR tyrosine kinase inhibitors, a T790M mutation was revealed by liquid biopsy. Hemodialysis was started three times a week because chronic renal failure worsened during treatment. Although the subsequent administration of osimertinib (80 mg, daily), resulted in a tumor shrinkage and a gradual increase in the plasma concentration of osimertinib, which resulted in grade 3 general fatigue. Reducing the dosage of osimertinib decreased its plasma concentration, leading to an improvement in his adverse event. Subsequently, with by adjusting the dosage while periodically measuring the plasma concentration of osimertinib, a stable therapeutic effect was sustained over the long term with no symptoms. Periodic plasma concentration measurements may be indispensable for successful treatment with osimertinib in hemodialysis patients.
DOI: 10.6084/m9.figshare.24031752
title: Supplementary Material for: Exclusive and solitary facial porokeratosis: pathogenesis and literature reappraisal of a rare entity

description: Porokeratosis are a group of well-known clinically distinct entities, characterised by different clinical aspects, but sharing a single common histological aspect, namely the cornoid lamella. Usually, porokeratosis occurs in the limbs and trunk, while they rarely involve the face, especially as exclusive, single and solitary lesion. We report the case of a 52-year-old Caucasian woman, with a 11-month history of a 2 cm slowly growing solitary, keratotic lesion on her left cheekbone. The patient did not present other cutaneous lesions on the face, as well as in other body sites. A cutaneous biopsy showed epidermal hyperplasia, with multiple, sharply defined cornoid lamella, associated with an underlying attenuation of the granular layer and scattered dyskeratotic cells in the spinous layer. The superficial dermis underneath showed a mild lymphocytic infiltrate and fibrosis with remodelled collagen bundles. A final diagnosis of solitary facial porokeratosis was made.