cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.5281/zenodo.18394391
title: THE INFLUENCE OF NUTRITION ON THE FORMATION OF PANCREATIC ENZYME SECRETION AND HOMEOSTASIS IN RATS OF DIFFERENT AGES DURING POSTNATAL ONTOGENESIS

description: Turli yoshdagi kalamushlar me'da osti bezi fermentlar sekretsiyasi va gomeostazining shakllanishga oziqlanishning ta'sirini o'rganishdan iborat.  Tajribalar institut vivariysidagi turli yoshdagi (15 kunlik, 1 oylik, 1.5 oylik, 2 oylik, 3 oylik va 4 oylik) oq, zotsiz, erkak kalamushlarda bajarilgan. Kalamushlar me'da osti bezi gomogenati va qonidagi amilolitik va lipolitik faolliklar o'rganilgan.

Olingan natijalarga ko'ra kalamushlar yoshi ulg'aygan sari me'da osti bezi to'qimasi amilolitik faolligining ortish keskinligi yuqoriroq darajada amalga oshdi. Yosh kalamushlarda yetuklariga nisbatan amilolitik fermentning qonga inkretsiya darajasi yuqoriroq bo'ldi. Kuzatuvimizdagi kalamushlarning har bir yoshga ulg'ayishi davomida ma'lum darajada lipolitik faollikni bir xil ortishi kuzatildi. Oqsilga boy ovqat bilan ozuqlantirilgan kalamushlarda har ikkala fermentlar (amilaza, lipaza) faolligining postnatal ontogenezda shakllanishi tezlashdi.
DOI: 10.5281/zenodo.18394392
title: THE INFLUENCE OF NUTRITION ON THE FORMATION OF PANCREATIC ENZYME SECRETION AND HOMEOSTASIS IN RATS OF DIFFERENT AGES DURING POSTNATAL ONTOGENESIS

description: Turli yoshdagi kalamushlar me'da osti bezi fermentlar sekretsiyasi va gomeostazining shakllanishga oziqlanishning ta'sirini o'rganishdan iborat.  Tajribalar institut vivariysidagi turli yoshdagi (15 kunlik, 1 oylik, 1.5 oylik, 2 oylik, 3 oylik va 4 oylik) oq, zotsiz, erkak kalamushlarda bajarilgan. Kalamushlar me'da osti bezi gomogenati va qonidagi amilolitik va lipolitik faolliklar o'rganilgan.

Olingan natijalarga ko'ra kalamushlar yoshi ulg'aygan sari me'da osti bezi to'qimasi amilolitik faolligining ortish keskinligi yuqoriroq darajada amalga oshdi. Yosh kalamushlarda yetuklariga nisbatan amilolitik fermentning qonga inkretsiya darajasi yuqoriroq bo'ldi. Kuzatuvimizdagi kalamushlarning har bir yoshga ulg'ayishi davomida ma'lum darajada lipolitik faollikni bir xil ortishi kuzatildi. Oqsilga boy ovqat bilan ozuqlantirilgan kalamushlarda har ikkala fermentlar (amilaza, lipaza) faolligining postnatal ontogenezda shakllanishi tezlashdi.
DOI: 10.5061/dryad.h70rxwdf6
title: Evidence of links between haematological condition and foraging behaviour in Northern gannets (Morus bassanus)

description: Haematological analyses can reveal the physiological condition of birds,
 who are known to efficiently disguise symptoms of stress and disease.
 However, interpretation of such analyses requires species-specific
 baseline data, which are lacking for most free-living seabird species. We
 provide baseline reference data for several haematological parameters in
 Northern gannets (Morus bassanus) and combine this with telemetry and
 dietary data to understand the links between haemotologic condition and
 foraging behaviour. Blood samples were collected from breeding Northern
 gannets in July 2017 (n = 15) and 2018 (n = 28), which were also equipped
 with GPS tags. Smears were prepared for performing blood cell counts,
 including immature erythrocyte and microcyte percentages, total and
 differential leucocyte counts, heterophil:lymphocyte (H:L) ratio, and
 total thrombocyte count, the remaining blood was used for stable isotope
 analysis, and foraging behaviours were inferred from the recovered tag
 data. Blood cell counts revealed that the sampled birds were highly
 stressed and some showed an immune response, evident from the abnormal
 leucocyte counts and H:L ratio. There were no sex-related differences in
 haematological parameters or diet, in contrast to foraging parameters
 where females undertook longer trips than males and spent proportionately
 more time in search behaviours. The percentage time spent actively
 foraging was negatively correlated with the percentage of eosinophils.
 While there was no direct link between haematologic condition and diet,
 one bird feeding at a relatively low trophic level undertook exceptionally
 short foraging trips and showed abnormal blood cell counts. This suggests
 a link between haematologic condition and foraging ecology that can be
 employed in assessing seabird health.
description: Blood samples were collected from the tarsal vein of each bird.
 Birds were also travked using GPS loggers (i-gotu GT120, mobile action
 technology) attached to the feathers using waterproof tape, and removed on
 recapture of the bird.  2-3 breast feathers were plucked for genetic
 sexing following Griffiths <i>et al.</i>(1998). 60 µl of blood
 was mixed with an equal volume of EDTA, with a standardised 60 µl of this
 mixture used for preparing the smears. Blood smears were prepared using
 the two-slide wedge technique (Coles, 1986), which were then allowed to
 air dry. Remaining blood samples were centrifuged at 1600rpm for 10
 minutes. The red blood cell component was dried at 60 degrees C for 24
 hours and then ground to a fine powder and lipids were removed using a 2:1
 mix of chloroform:methanol before being sent for analysis of Carbon and
 Nitrogen stable isotopes. We provide raw tracking data
 from the GPS tags and Carbon/Nitrogen stable isotope values from sampled
 birds.
description: GPS locations were sampled at 3-minute intervals. We provide raw
 tracking data so that behavioural annotation can be replicated
DOI: 10.5061/dryad.0k6djh9wk
title: Data from: samc: An R package for connectivity modeling with spatial absorbing Markov chains

description: Quantifying landscape connectivity is fundamental to better understand and
 predict how populations respond to environmental change. Currently,
 popular methods to quantify landscape connectivity emphasize how landscape
 features provide resistance to movement. While many tools are available to
 quantify landscape resistance, these do not discern between two
 fundamentally different sources of resistance: movement behavior and
 mortality. To address this issue, we developed the samc package that
 quantifies landscape connectivity using absorbing Markov chain theory.
 Within this mathematical framework, movements are represented as transient
 states in the Markov chain, while mortality is represented by transitions
 to absorbing states. Not only does this framework explicitly account for
 these different issues, it provides a probabilistic approach that can
 incorporate both short-term and long-term dynamics, as well as species
 distribution and abundance. The package includes functions to quantify
 life expectancy, long-term visitation rates, and various spatially and
 temporally explicit measures of mortality and movement at the local and
 landscape scale. These functions in samc have been optimized to find
 computationally practical solutions in landscapes of &gt; 2 × 106
 cells. Here, we illustrate the workflow of the samc package with publicly
 available movement and mortality data on the endangered Florida panther
 (Puma concolor coryi). This analysis showed that movement and mortality
 are generally correlated except for sites near roads that are within the
 dispersal range of source locations which had higher mortality risk. This
 pattern would have been undetectable with current methods that quantify
 movement resistance. Overall, the samc package provides a means for
 implementing spatial absorbing Markov chains that can distinguish between
 movement behavior and mortality resulting in more reliable landscape
 connectivity measures.
DOI: 10.17909/52x1-bv68
title: test
DOI: 10.5061/dryad.f4qrfj6s8
title: Butterfly phenology in Mediterranean mountains using space-for-time substitution

description: Inferring species' responses to climate change in the absence of
 long-term time series data is a challenge, but can be achieved by
 substituting space for time. For example, thermal elevational gradients
 represent suitable proxies to study phenological responses to warming. We
 used butterfly data from two Mediterranean mountain areas to test whether
 mean dates of appearance of communities and individual species show a
 delay with increasing altitude, and an accompanying shortening in the
 duration of flight periods. We found a 14-day delay in the mean date of
 appearance per kilometre increase in altitude for butterfly communities
 overall, and an average 23-day shift for 26 selected species, alongside
 average summer temperature lapse rates of 3°C per km. At higher elevations
 there was a shortening of the flight period for the community of three
 days/km, with an 8.8 day average decline per km for individual species.
 Rates of phenological delay differed significantly between the two
 mountain ranges, although this did not seem to result from the respective
 temperature lapse rates. These results suggest that climate warming could
 lead to advanced and lengthened flight periods for Mediterranean mountain
 butterfly communities. However, although multivoltine species showed the
 expected response of delayed and shortened flight periods at higher
 elevations, univoltine species showed more pronounced patterns in terms of
 species appearance. Hence, whilst projections of overall community
 responses to climate change may benefit from space-for-time substitutions,
 understanding species-specific responses to local features of habitat and
 climate may be needed to accurately predict the effects of climate change
 on phenology.
DOI: 10.5061/dryad.95x69p8fm
title: Biotic and anthropogenic forces rival climatic/abiotic factors in determining global plant population growth and fitness

description: Multiple, simultaneous environmental changes, in climatic/abiotic factors,
 in interacting species, and in direct human influences, are impacting
 natural populations and thus biodiversity, ecosystem services, and
 evolutionary trajectories. Determining whether the magnitudes of the
 population impacts of abiotic, biotic, and anthropogenic drivers differ,
 accounting for their direct effects and effects mediated through other
 drivers, would allow us to better predict population fates and design
 mitigation strategies. We compiled 644 paired values of the population
 growth rate (lambda) from high and low levels of an identified driver from
 demographic studies of terrestrial plants. Among abiotic drivers, natural
 disturbance (not climate), and among biotic drivers, interactions with
 neighboring plants had the strongest effects on lambda. However, when
 drivers were combined into the three main types, their average effects on
 lambda did not differ. For the subset of studies that measured both the
 average and variability of the driver, lambda was more sensitive to one
 standard deviation of change in abiotic drivers relative to biotic
 drivers, but sensitivity to biotic drivers was still substantial. Similar
 impact magnitudes for abiotic/biotic/anthropogenic drivers holds for
 plants of different growth forms, for different latitudinal zones, and for
 biomes characterized by harsher or milder abiotic conditions, suggesting
 that all three drivers have equivalent impacts across a variety of
 contexts. Thus the best available information about the integrated effects
 of drivers on all demographic rates provides no justification for ignoring
 drivers of any of these three types when projecting ecological and
 evolutionary responses of populations and of biodiversity to environmental
 changes.
description: The main data consist of pairs of estimates of population growth
 rates of terrestrial plants, one from a relatively high and one from a
 relatively low level of an identified environmental driver (i.e., a factor
 such as climate, soil, interactions with competitors, herbivores,
 pathogens, or pollinators, or anthropogenic impacts).  These estimates
 were taken from published studies. When available, levels of the
 environmental driver are also included, along with meta-data from each
 site (e.g., publication citation, species name, geographical location,
 etc.).  Dataset S1 includes the full data extracted
 from the data sources; see &lt;Raw lambda
 estimates.xlsx&gt; Dataset S2 includes all data
 used in the statistical analyses, based on the full data from Dataset S1;
 see &lt;Data for analysis.xlxs&gt; The file
 &lt;Source references.pdf&gt; gives the full citations for the
 papers in Datasets S1 and S2.
description: The datasets are in the form of an Excel file. The second
 worksheet in each file describes what each column in the first datasheet
 represents.
DOI: 10.5061/dryad.zkh189367
title: Respirometric screening and characterization of mitochondrial toxicants within the ToxCast phase I and II chemical libraries

description: Mitochondrial toxicity drives several adverse health outcomes. Current
 high-throughput screening assays for chemically-induced mitochondrial
 toxicity typically measure changes to mitochondrial structure and may not
 detect known mitochondrial toxicants. We adapted a respirometric screening
 assay (RSA) measuring mitochondrial function to screen ToxCast chemicals
 in HepG2 cells using a tiered testing strategy. Of 1,042 chemicals
 initially screened at a single maximal concentration, 243 actives were
 identified and re-screened at seven concentrations. Concentration-response
 data for three respiration phases confirmed activity and indicated a
 mechanism for 193 mitochondrial toxicants: 149 electron transport chain
 inhibitors (ETCi), 15 uncouplers and 29 ATP synthase inhibitors.
 Subsequently, an electron flow assay (EFA) was used to identify the target
 complex for 84 of the 149 ETCi. Sixty reference chemicals were used to
 compare the RSA to existing ToxCast and Tox21 mitochondrial toxicity
 assays. The RSA was most predictive (accuracy = 90%) of mitochondrial
 toxicity. The Tox21 mitochondrial membrane potential assay was also highly
 predictive (accuracy = 87%) of bioactivity but underestimated the potency
 of well-known ETCi and provided no mechanistic information. The tiered RSA
 approach accurately identifies and characterizes mitochondrial toxicants
 acting through diverse mechanisms and at a throughput sufficient to screen
 large chemical inventories. The EFA provides additional confirmation and
 detailed mechanistic understanding for ETCi, the most common type of
 mitochondrial toxicants among ToxCast chemicals. The mitochondrial
 toxicity screening approach described herein may inform hazard assessment
 and the in vitro bioactive concentrations used to derive relevant doses
 for screening level chemical assessment using new approach methodologies.
DOI: 10.15468/dl.4ppu73
title: Occurrence Download

description: A dataset containing 580 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Trichosanthes cucumerina",
 "HasCoordinate is true",
 "BasisOfRecord is one of (Specimen)"
 ]
}

 The dataset includes 580 records from 63 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0002097-260126135527185/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.5061/dryad.xd2547dcw
title: Data from: Accurate genomic predictions for chronic wasting disease in U.S. white-tailed deer

description: The geographic expansion of chronic wasting disease (CWD) in U.S.
 white-tailed deer (Odocoileus virginianus) has been largely unabated by
 best management practices, diagnostic surveillance, and depopulation of
 positive herds. Using a custom Affymetrix Axiom® single nucleotide
 polymorphism (SNP) array, we demonstrate that both differential
 susceptibility to CWD, and natural variation in disease progression, are
 moderately to highly heritable ( among farmed U.S. white-tailed deer, and
 that loci other than PRNP are involved. Genome-wide
 association analyses using 123,987 quality filtered SNPs for a
 geographically diverse cohort of 807 farmed U.S. white-tailed deer (n =
 284 CWD positive; n = 523 CWD non-detect) confirmed the prion gene (PRNP;
 G96S) as a large-effect risk locus (P-value &lt; 6.3E-11), as
 evidenced by the estimated proportion of phenotypic variance explained
 (PVE ≥ 0.05), but also demonstrated that more phenotypic variance was
 collectively explained by loci other than PRNP. Genomic
 best linear unbiased prediction (GBLUP; n = 123,987 SNPs)
 with k-fold cross validation (k =
 3; k = 5) and random sampling (n = 50 iterations) for
 the same cohort of 807 farmed U.S. white-tailed deer produced mean genomic
 prediction accuracies ≥ 0.81; thereby providing the necessary foundation
 for exploring a genomically-estimated CWD eradication program.
description: The geographic expansion of chronic wasting disease (CWD) in U.S.
 white-tailed deer has been largely unabated by best management practices,
 diagnostic surveillance, and depopulation of positive herds.  Using a
 custom SNP array, we show that differential susceptibility to CWD is
 heritable, and that loci other than <i>PRNP</i> are involved.
  Genomic prediction with <i>k</i>-fold cross validation for a
 geographically diverse cohort of farmed U.S. white-tailed deer produced
 prediction accuracies ≥ 0.81.
DOI: 10.5061/dryad.v15dv41s7
title: Data from: Trophic response to ecological conditions of habitats: evidence from trophic variability of freshwater fish

description: 1. The ecological niche is a fundamental concept for understanding the
 interaction among species that can change the function at the level of
 species and guilds to adapt ecological conditions. The stable isotope
 analysis has conventionally been employed to evaluate such adaptabilities
 frequently in the scenopoetic and bionomic views, as isotopic niche width.
 2. We applied compound-specific isotope analysis (CSIA) of nitrogen within
 amino acids to understand trophic variability of the pike gudgeon
 Pseudogobio esocinus and the largemouth bass Micropterus salmoides as
 representative specialist and generalist fish species, respectively, in 16
 ecologically-variable habitats on the four major rivers of Korea. 3. There
 is little variation (1σ) in the trophic position (TP) among the habitats
 for P. esocinus (±0.2), but a considerably large variation for M.
 salmoides (±0.6). Moreover, the TP of M. salmoides is negatively
 correlated with benthic invertebrate indices in the habitats, while the TP
 of P. esocinus shows no significant correlation with any indices. These
 two representative fish species thus have different trophic responses to
 ecological conditions, which is well consistent with known differences in
 the trophic niche between specialists (i.e., small niche width) and
 generalists (i.e., large niche width). 4. During the last four decades,
 the traditional stable isotope analysis for bulk carbon and nitrogen in
 samples has not been able to deconvolute ‘scenopoetic’ and ‘bionomic’
 information. However, in the present study, we demonstrated that CSIA of
 amino acids can isolate trophic niche from traditional ecological niche
 that is accompanying both trophic and habitat information, and evaluated
 how biological and ecological indices affect to the trophic responses of
 specialists and generalists.
DOI: 10.5061/dryad.kwh70rz0c
title: Unraveling the roles of various ecological factors in seedling recruitment to facilitate plant regeneration

description: Unraveling the mechanisms causing restricted regeneration and limited
 distribution range has become a core issue for biodiversity conservation.
 Anthropogenic disturbances are changing a variety of ecological factors,
 but how their relative importance varies across multiple regeneration
 stages is still unclear even in a single species. In this study, we
 focused on Metasequoia glyptostroboides, a relict species suffering a
 severely restricted regeneration in the wild, and performed controlled
 experiments using 54,600 seeds to investigate seedling emergence and
 growth in both its natural and adjacent unoccupied habitats to disentangle
 the roles of seed availability, interspecific competition and
 herbivore/omnivore attack across early regeneration stages. Our results
 showed that these factors mainly exerted their predominant effects at
 initial regeneration stages. Compared with herbivore/omnivore attack, seed
 availability and interspecific competition were the crucial factors
 regulating seedling emergence. The first-year seedling survival rate was
 only significantly influenced by interspecific competition, and the
 survival of second-year seedlings was independent of all these factors.
 Moreover, we detected similar impacts of these factors in the adjacent
 unoccupied habitats to those in the natural habitats, indicating their
 roles in limiting population expansion. Our findings provide some
 suggestions to assist the natural regeneration and range expansion of M.
 glyptostroboides, and our experiment design can be applied in the
 assessment of endangerment causes for other endangered plants.
DOI: 10.5061/dryad.xd2547dcx
title: Data from: Attention-related modulation of caudate neurons depends on superior colliculus activity

description: Recent work has implicated the basal ganglia in visual perception and
 attention, in addition to their traditional role in motor control. The
 basal ganglia, especially the caudate nucleus “head” (CDh) of the
 striatum, receive indirect anatomical connections from the superior
 colliculus (SC), a midbrain structure that is known to play a crucial role
 in the control of visual attention. To test the possible functional
 relationship between these subcortical structures, we recorded CDh
 neuronal activity before and during unilateral SC inactivation in a
 spatial attention task. SC inactivation significantly altered the
 attention-related modulation of CDh neurons and strongly impaired the
 classification of task epochs based on CDh activity. Only inactivation of
 the same-side of SC as recorded CDh neurons, not the opposite-side, had
 these effects. These results demonstrate a novel interaction between SC
 activity and attention-related visual processing in the basal ganglia.
description: See Methods https://www.biorxiv.org/content/10.1101/843235v1
description: See attached readme files.