cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.6395546
title: Additional file 9: of Origin, evolution, and divergence of plant class C GH9 endoglucanases

description: Table S5. Distribution of low strength patterns in non class C taxa. (XLSX 41 kb)
DOI: 10.6084/m9.figshare.6395543
title: Additional file 6: of Distribution of ncRNAs expression across hypothalamic-pituitary-gonadal axis in Capra hircus

description: Pathways identified for (experimentally observed) genes targeted by upregulated miRNA expressed in the pituitary, hypothalamus and ovary. (XLSX 148 kb)
DOI: 10.6084/m9.figshare.6395546.v1
title: Additional file 9: of Origin, evolution, and divergence of plant class C GH9 endoglucanases

description: Table S5. Distribution of low strength patterns in non class C taxa. (XLSX 41 kb)
DOI: 10.6084/m9.figshare.6395543.v1
title: Additional file 6: of Distribution of ncRNAs expression across hypothalamic-pituitary-gonadal axis in Capra hircus

description: Pathways identified for (experimentally observed) genes targeted by upregulated miRNA expressed in the pituitary, hypothalamus and ovary. (XLSX 148 kb)
DOI: 10.6084/m9.figshare.6395534
title: Additional file 8: of Origin, evolution, and divergence of plant class C GH9 endoglucanases

description: Table S2. CBM49 based classification of land plants. (XLSX 22 kb)
DOI: 10.6084/m9.figshare.6395534.v1
title: Additional file 8: of Origin, evolution, and divergence of plant class C GH9 endoglucanases

description: Table S2. CBM49 based classification of land plants. (XLSX 22 kb)
DOI: 10.6084/m9.figshare.6395519
title: Additional file 7: of Origin, evolution, and divergence of plant class C GH9 endoglucanases

description: Table S4. Posterior probabilities for parameters utilized to date GH9/ CBM49 evolution across taxa. (XLSX 15 kb)
DOI: 10.6084/m9.figshare.6395519.v1
title: Additional file 7: of Origin, evolution, and divergence of plant class C GH9 endoglucanases

description: Table S4. Posterior probabilities for parameters utilized to date GH9/ CBM49 evolution across taxa. (XLSX 15 kb)
DOI: 10.6084/m9.figshare.6395513
title: Additional file 2: of Genome-wide association study meta-analysis identifies five new loci for systemic lupus erythematosus

description: Table S3. Association results for the 52 previously known SLE risk loci in the Spain GWAS. Table S4. Pathway association results after combining the two SLE cohorts (combined raw p value &lt;0.05). Table S5. List of biological pathways significantly associated with ST8SIA4 gene network. Table S6. List of biological pathways significantly associated with ARHGAP27 gene network. (XLSX 48 kb)
DOI: 10.6084/m9.figshare.6395513.v1
title: Additional file 2: of Genome-wide association study meta-analysis identifies five new loci for systemic lupus erythematosus

description: Table S3. Association results for the 52 previously known SLE risk loci in the Spain GWAS. Table S4. Pathway association results after combining the two SLE cohorts (combined raw p value &lt;0.05). Table S5. List of biological pathways significantly associated with ST8SIA4 gene network. Table S6. List of biological pathways significantly associated with ARHGAP27 gene network. (XLSX 48 kb)
DOI: 10.6084/m9.figshare.6395501
title: Additional file 6: of Origin, evolution, and divergence of plant class C GH9 endoglucanases

description: Table S3. Maximum likelihood based evaluation of amino acid substitution models. (XLSX 30 kb)
DOI: 10.6084/m9.figshare.6395501.v1
title: Additional file 6: of Origin, evolution, and divergence of plant class C GH9 endoglucanases

description: Table S3. Maximum likelihood based evaluation of amino acid substitution models. (XLSX 30 kb)
DOI: 10.6084/m9.figshare.6395495
title: Additional file 13: of Silicon protects soybean plants against Phytophthora sojae by interfering with effector-receptor expression

description: Table S9. Expression data of hormone-related genes. Normalized mean (n = 5), fold-change and FDR p-value of five genes involved in SA metabolism (sheet 1), and13 genes involved in JA metabolism (sheet 2) in soybean plants treated (Si+) or not (Si-) with silicon (Si) at 0, 4, 7, and 14 dpi with Phytophthora sojae. (XLSX 36 kb)
DOI: 10.6084/m9.figshare.6395495.v1
title: Additional file 13: of Silicon protects soybean plants against Phytophthora sojae by interfering with effector-receptor expression

description: Table S9. Expression data of hormone-related genes. Normalized mean (n = 5), fold-change and FDR p-value of five genes involved in SA metabolism (sheet 1), and13 genes involved in JA metabolism (sheet 2) in soybean plants treated (Si+) or not (Si-) with silicon (Si) at 0, 4, 7, and 14 dpi with Phytophthora sojae. (XLSX 36 kb)
DOI: 10.6084/m9.figshare.6395489
title: Additional file 3: of Distribution of ncRNAs expression across hypothalamic-pituitary-gonadal axis in Capra hircus

description: List of differentially expressed ncRNA (DE-ncRNA) (FDR
DOI: 10.6084/m9.figshare.6395489.v1
title: Additional file 3: of Distribution of ncRNAs expression across hypothalamic-pituitary-gonadal axis in Capra hircus

description: List of differentially expressed ncRNA (DE-ncRNA) (FDR
DOI: 10.6084/m9.figshare.6395486
title: Additional file 5: of Origin, evolution, and divergence of plant class C GH9 endoglucanases

description: Table S1. GH9 domain based classification of taxa. (XLSX 54 kb)
DOI: 10.6084/m9.figshare.6395486.v1
title: Additional file 5: of Origin, evolution, and divergence of plant class C GH9 endoglucanases

description: Table S1. GH9 domain based classification of taxa. (XLSX 54 kb)
DOI: 10.6084/m9.figshare.6395477
title: Additional file 12: of Silicon protects soybean plants against Phytophthora sojae by interfering with effector-receptor expression

description: Table S8. Expression data of secondary metabolism-related genes. Normalized mean (n = 5), fold-change and FDR p-value of 31 genes involved in flavonoid metabolism (sheet 1), nine genes involved in isoflavone metabolism (sheet 2) and 15 genes involved in isoprenoid metabolism (sheet 3) in soybean plants treated (Si+) or not (Si-) with silicon (Si) at 0, 4, 7, and 14 dpi with Phytophthora sojae. (XLSX 48 kb)
DOI: 10.6084/m9.figshare.6395477.v1
title: Additional file 12: of Silicon protects soybean plants against Phytophthora sojae by interfering with effector-receptor expression

description: Table S8. Expression data of secondary metabolism-related genes. Normalized mean (n = 5), fold-change and FDR p-value of 31 genes involved in flavonoid metabolism (sheet 1), nine genes involved in isoflavone metabolism (sheet 2) and 15 genes involved in isoprenoid metabolism (sheet 3) in soybean plants treated (Si+) or not (Si-) with silicon (Si) at 0, 4, 7, and 14 dpi with Phytophthora sojae. (XLSX 48 kb)
DOI: 10.6084/m9.figshare.6395468
title: Additional file 4: of Origin, evolution, and divergence of plant class C GH9 endoglucanases

description: Text S2. Sequences of CBM49 in predicted class C land plants (fasta). (FASTA 11 kb)
DOI: 10.6084/m9.figshare.6395468.v1
title: Additional file 4: of Origin, evolution, and divergence of plant class C GH9 endoglucanases

description: Text S2. Sequences of CBM49 in predicted class C land plants (fasta). (FASTA 11 kb)
DOI: 10.6084/m9.figshare.6395459
title: Additional file 3: of Origin, evolution, and divergence of plant class C GH9 endoglucanases

description: Text S4. Sequences of land plants (CBM49, pattern 20; fasta). (FASTA 114 kb)
DOI: 10.6084/m9.figshare.6395459.v1
title: Additional file 3: of Origin, evolution, and divergence of plant class C GH9 endoglucanases

description: Text S4. Sequences of land plants (CBM49, pattern 20; fasta). (FASTA 114 kb)
DOI: 10.6084/m9.figshare.6395450
title: Additional file 1: of Distribution of ncRNAs expression across hypothalamic-pituitary-gonadal axis in Capra hircus

description: Primer list and sequences used for Real Time validation experiment. (XLSX 9 kb)
DOI: 10.6084/m9.figshare.6395450.v1
title: Additional file 1: of Distribution of ncRNAs expression across hypothalamic-pituitary-gonadal axis in Capra hircus

description: Primer list and sequences used for Real Time validation experiment. (XLSX 9 kb)
DOI: 10.6084/m9.figshare.6395441
title: Additional file 2: of Origin, evolution, and divergence of plant class C GH9 endoglucanases

description: Text S3. Sequences with pattern 20 across all taxa (fasta). (FASTA 197 kb)
DOI: 10.6084/m9.figshare.6395441.v1
title: Additional file 2: of Origin, evolution, and divergence of plant class C GH9 endoglucanases

description: Text S3. Sequences with pattern 20 across all taxa (fasta). (FASTA 197 kb)
DOI: 10.6084/m9.figshare.6395438
title: Additional file 10: of Silicon protects soybean plants against Phytophthora sojae by interfering with effector-receptor expression

description: Table S7. Expression data of a) protease inhibitor genes and b) polyphenol oxidase genes. Normalized mean (n = 5), fold-change and FDR p-value of 13 protease inhibitor genes (sheet 1) and five polyphenol oxidase genes (sheet 2) in soybean plants treated (Si+) or not (Si-) with silicon (Si) at 0, 4, 7, and 14 dpi with Phytophthora sojae. (XLSX 37 kb)
DOI: 10.6084/m9.figshare.6395438.v1
title: Additional file 10: of Silicon protects soybean plants against Phytophthora sojae by interfering with effector-receptor expression

description: Table S7. Expression data of a) protease inhibitor genes and b) polyphenol oxidase genes. Normalized mean (n = 5), fold-change and FDR p-value of 13 protease inhibitor genes (sheet 1) and five polyphenol oxidase genes (sheet 2) in soybean plants treated (Si+) or not (Si-) with silicon (Si) at 0, 4, 7, and 14 dpi with Phytophthora sojae. (XLSX 37 kb)
DOI: 10.6084/m9.figshare.6395423
title: MOESM4 of Age-related DNA methylation changes are tissue-specific with ELOVL2 promoter methylation as exception

description: Additional file 4: Table S3. Number of tissues a gene near gain-aDMPs was found.
DOI: 10.6084/m9.figshare.6395423.v1
title: MOESM4 of Age-related DNA methylation changes are tissue-specific with ELOVL2 promoter methylation as exception

description: Additional file 4: Table S3. Number of tissues a gene near gain-aDMPs was found.
DOI: 10.6084/m9.figshare.6395420
title: Additional File 10:

description: Non-redundant dataset of ncRNA from ovary, pituitary and hypothalamus in fasta format. (TXT 64614 kb)
DOI: 10.6084/m9.figshare.6395420.v1
title: Additional File 10:

description: Non-redundant dataset of ncRNA from ovary, pituitary and hypothalamus in fasta format. (TXT 64614 kb)
DOI: 10.6084/m9.figshare.6395411
title: Additional file 1: of Origin, evolution, and divergence of plant class C GH9 endoglucanases

description: Text S1. Sequences of GH9 in all taxa (fasta). (FASTA 283 kb)
DOI: 10.6084/m9.figshare.6395411.v1
title: Additional file 1: of Origin, evolution, and divergence of plant class C GH9 endoglucanases

description: Text S1. Sequences of GH9 in all taxa (fasta). (FASTA 283 kb)
DOI: 10.6084/m9.figshare.6395396
title: Additional file 19: of Origin, evolution, and divergence of plant class C GH9 endoglucanases

description: Text S7. Maximum clade credibility tree to assess divergence of the CBM49 in land plants. (TXT 2 kb)
DOI: 10.6084/m9.figshare.6395396.v1
title: Additional file 19: of Origin, evolution, and divergence of plant class C GH9 endoglucanases

description: Text S7. Maximum clade credibility tree to assess divergence of the CBM49 in land plants. (TXT 2 kb)
DOI: 10.6084/m9.figshare.6395393
title: Additional file 4: of Isoform-specific deletion of PKM2 constrains tumor initiation in a mouse model of soft tissue sarcoma

description: Table S1. Raw data for LC-MS metabolomics on KP M2+/+ and KP M2-/- sarcomas. Related to Fig. 5. This table contains all the LC-MS metabolomics data. Includes normalization and statistical analysis for each measured metabolite.Â (XLSX 140 kb)
DOI: 10.6084/m9.figshare.6395393.v1
title: Additional file 4: of Isoform-specific deletion of PKM2 constrains tumor initiation in a mouse model of soft tissue sarcoma

description: Table S1. Raw data for LC-MS metabolomics on KP M2+/+ and KP M2-/- sarcomas. Related to Fig. 5. This table contains all the LC-MS metabolomics data. Includes normalization and statistical analysis for each measured metabolite.Â (XLSX 140 kb)
DOI: 10.6084/m9.figshare.6395387
title: MOESM2 of Age-related DNA methylation changes are tissue-specific with ELOVL2 promoter methylation as exception

description: Additional file 2: Table S2. Identified aDMPs per tissue.
DOI: 10.6084/m9.figshare.6395387.v1
title: MOESM2 of Age-related DNA methylation changes are tissue-specific with ELOVL2 promoter methylation as exception

description: Additional file 2: Table S2. Identified aDMPs per tissue.
DOI: 10.6084/m9.figshare.6395372
title: Additional file 17: of Origin, evolution, and divergence of plant class C GH9 endoglucanases

description: Text S5. Maximum clade credibility tree to assess evolution of the GH9 domain. (TXT 5 kb)
DOI: 10.6084/m9.figshare.6395372.v1
title: Additional file 17: of Origin, evolution, and divergence of plant class C GH9 endoglucanases

description: Text S5. Maximum clade credibility tree to assess evolution of the GH9 domain. (TXT 5 kb)
DOI: 10.6084/m9.figshare.6395354
title: Additional file 16: of Origin, evolution, and divergence of plant class C GH9 endoglucanases

description: Text S10. Distribution of TM and SP in land plants (PHOBIUS). (TXT 9 kb)
DOI: 10.6084/m9.figshare.6395354.v1
title: Additional file 16: of Origin, evolution, and divergence of plant class C GH9 endoglucanases

description: Text S10. Distribution of TM and SP in land plants (PHOBIUS). (TXT 9 kb)
DOI: 10.6084/m9.figshare.6395339
title: MOESM16 of Age-related DNA methylation changes are tissue-specific with ELOVL2 promoter methylation as exception

description: Additional file 16: Table S8. Enriched GO terms for loss-aDMPs per tissue.
DOI: 10.6084/m9.figshare.6395339.v1
title: MOESM16 of Age-related DNA methylation changes are tissue-specific with ELOVL2 promoter methylation as exception

description: Additional file 16: Table S8. Enriched GO terms for loss-aDMPs per tissue.
DOI: 10.6084/m9.figshare.6395333
title: Additional file 15: of Origin, evolution, and divergence of plant class C GH9 endoglucanases

description: Text S12. Distribution of TM and SP in land plants (MEMSAT-SVM). (ZIP 2102 kb)
DOI: 10.6084/m9.figshare.6395333.v1
title: Additional file 15: of Origin, evolution, and divergence of plant class C GH9 endoglucanases

description: Text S12. Distribution of TM and SP in land plants (MEMSAT-SVM). (ZIP 2102 kb)
DOI: 10.6084/m9.figshare.6395321
title: MOESM15 of Age-related DNA methylation changes are tissue-specific with ELOVL2 promoter methylation as exception

description: Additional file 15: Table S7. Frequency of loss-aDMPs near genes.
DOI: 10.6084/m9.figshare.6395318
title: Additional file 14: of Origin, evolution, and divergence of plant class C GH9 endoglucanases

description: Text S11. Distribution of TM and SP in land plants (DAS-TMfilter). (TXT 36 kb)
DOI: 10.6084/m9.figshare.6395321.v1
title: MOESM15 of Age-related DNA methylation changes are tissue-specific with ELOVL2 promoter methylation as exception

description: Additional file 15: Table S7. Frequency of loss-aDMPs near genes.
DOI: 10.6084/m9.figshare.6395318.v1
title: Additional file 14: of Origin, evolution, and divergence of plant class C GH9 endoglucanases

description: Text S11. Distribution of TM and SP in land plants (DAS-TMfilter). (TXT 36 kb)
DOI: 10.6084/m9.figshare.6395312
title: Additional file 13 of Origin, evolution, and divergence of plant class C GH9 endoglucanases

description: Text S9. Distribution of low strength patterns in land plants. (TXT 84 kb)
DOI: 10.6084/m9.figshare.6395312.v1
title: Additional file 13 of Origin, evolution, and divergence of plant class C GH9 endoglucanases

description: Text S9. Distribution of low strength patterns in land plants. (TXT 84 kb)
DOI: 10.6084/m9.figshare.6395303
title: MOESM14 of Age-related DNA methylation changes are tissue-specific with ELOVL2 promoter methylation as exception

description: Additional file 14: Table S6. Number of tissues a gene near loss-aDMPs was found.
DOI: 10.6084/m9.figshare.6395303.v1
title: MOESM14 of Age-related DNA methylation changes are tissue-specific with ELOVL2 promoter methylation as exception

description: Additional file 14: Table S6. Number of tissues a gene near loss-aDMPs was found.
DOI: 10.6084/m9.figshare.6395288
title: Additional file 12: of Origin, evolution, and divergence of plant class C GH9 endoglucanases

description: Table S8. Distribution of CBMs and low strength patterns in taxa. (XLSX 18 kb)
DOI: 10.6084/m9.figshare.6395288.v1
title: Additional file 12: of Origin, evolution, and divergence of plant class C GH9 endoglucanases

description: Table S8. Distribution of CBMs and low strength patterns in taxa. (XLSX 18 kb)
DOI: 10.6084/m9.figshare.6395279
title: MOESM13 of Age-related DNA methylation changes are tissue-specific with ELOVL2 promoter methylation as exception

description: Additional file 13: Table S5. Enriched GO terms for gain-aDMPs per tissue.
DOI: 10.6084/m9.figshare.6395279.v1
title: MOESM13 of Age-related DNA methylation changes are tissue-specific with ELOVL2 promoter methylation as exception

description: Additional file 13: Table S5. Enriched GO terms for gain-aDMPs per tissue.
DOI: 10.6084/m9.figshare.6395273
title: Additional file 11: of Origin, evolution, and divergence of plant class C GH9 endoglucanases

description: Table S7. Distribution of TM, SP, and CBM49 in land plants. (XLSX 22 kb)
DOI: 10.6084/m9.figshare.6395273.v1
title: Additional file 11: of Origin, evolution, and divergence of plant class C GH9 endoglucanases

description: Table S7. Distribution of TM, SP, and CBM49 in land plants. (XLSX 22 kb)
DOI: 10.6084/m9.figshare.6395255
title: Additional file 10: of Origin, evolution, and divergence of plant class C GH9 endoglucanases

description: Table S6. Distribution of low strength patterns in non class C land plants. (XLSX 19 kb)
DOI: 10.6084/m9.figshare.6395255.v1
title: Additional file 10: of Origin, evolution, and divergence of plant class C GH9 endoglucanases

description: Table S6. Distribution of low strength patterns in non class C land plants. (XLSX 19 kb)
DOI: 10.6084/m9.figshare.6395249
title: MOESM12 of Age-related DNA methylation changes are tissue-specific with ELOVL2 promoter methylation as exception

description: Additional file 12: Table S4. Frequency of gain-aDMPs near genes.
DOI: 10.6084/m9.figshare.6395249.v1
title: MOESM12 of Age-related DNA methylation changes are tissue-specific with ELOVL2 promoter methylation as exception

description: Additional file 12: Table S4. Frequency of gain-aDMPs near genes.
DOI: 10.6084/m9.figshare.6395228
title: Additional file 1: of Quantitative nuclear histomorphometry predicts oncotype DX risk categories for early stage ER+ breast cancer

description: Table S7. Features tested for significance, and considered for use in final analysis. Comprehensive list of features investigated for classification utility. Each feature was used to analyze epithelial and stromal nuclei separately. (XLSX 15Â kb)
DOI: 10.6084/m9.figshare.6395228.v1
title: Additional file 1: of Quantitative nuclear histomorphometry predicts oncotype DX risk categories for early stage ER+ breast cancer

description: Table S7. Features tested for significance, and considered for use in final analysis. Comprehensive list of features investigated for classification utility. Each feature was used to analyze epithelial and stromal nuclei separately. (XLSX 15Â kb)
DOI: 10.6084/m9.figshare.6395210
title: Additional file 1: of Transcription factor motif enrichment in whole transcriptome analysis identifies STAT4 and BCL6 as the most prominent binding motif in systemic juvenile idiopathic arthritis

description: Table S1. List of regulated genes with fold change (FC) &gt; 2 in patients with active disease (ad) versus inactive disease (id) showing signal intensity in both disease states, gene symbol and description. (XLSX 60Â kb)
DOI: 10.6084/m9.figshare.6395210.v1
title: Additional file 1: of Transcription factor motif enrichment in whole transcriptome analysis identifies STAT4 and BCL6 as the most prominent binding motif in systemic juvenile idiopathic arthritis

description: Table S1. List of regulated genes with fold change (FC) &gt; 2 in patients with active disease (ad) versus inactive disease (id) showing signal intensity in both disease states, gene symbol and description. (XLSX 60Â kb)
DOI: 10.6084/m9.figshare.6395123
title: Additional file 2: of Efficacy and safety of febuxostat extended release and immediate release in patients with gout and moderate renal impairment: phase II placebo-controlled study

description: Institutional review boards and reference numbers for the sites in this study. (XLSX 52Â kb)
DOI: 10.6084/m9.figshare.6395123.v1
title: Additional file 2: of Efficacy and safety of febuxostat extended release and immediate release in patients with gout and moderate renal impairment: phase II placebo-controlled study

description: Institutional review boards and reference numbers for the sites in this study. (XLSX 52Â kb)
DOI: 10.6084/m9.figshare.6395087
title: Tongxinluo attenuates reperfusion injury in diabetic hearts by angiopoietin-like 4-mediated protection of endothelial barrier integrity via PPAR-α pathway-Kang Qi-PLOS one

description: PLOS one
DOI: 10.6084/m9.figshare.6395087.v2
title: Tongxinluo attenuates reperfusion injury in diabetic hearts by angiopoietin-like 4-mediated protection of endothelial barrier integrity via PPAR-α pathway-Kang Qi-PLOS one

description: PLOS one
DOI: 10.6084/m9.figshare.6395087.v1
title: Table2-Kang Qi-PLOSone-permeability.xlsx

description: PLOS one
DOI: 10.6084/m9.figshare.6395051
title: Example Data to Share

description: Show how to share data
DOI: 10.6084/m9.figshare.6395051.v1
title: Example Data to Share

description: Show how to share data
DOI: 10.6084/m9.figshare.6395048
title: Nanofibrillated cellulose causes acute pulmonary inflammation that subsides within a month

description: Nanofibrillated cellulose (NFC) is a renewable nanomaterial that has beneficial uses in various applications such as packaging materials and paper. Like carbon nanotubes (CNT), NFCs have high aspect ratio and favorable mechanical properties. The aspect ratio also rises a concern whether NFC could pose a health risk and induce pathologies, similar to those triggered by multi-walled CNT. In this study, we explored the immunomodulatory properties of four NFCs <i>in vitro</i> and <i>in vivo</i>, and compared the results with data on bulk-sized cellulose fibrils and rigid multi-walled CNT (rCNT). Two of the NFCs were non-functionalized and two were carboxymethylated or carboxylated. We investigated the production of pro-inflammatory cytokines in differentiated THP-1 cells, and studied the pulmonary effects and biopersistence of the materials in mice. Our results demonstrate that one of the non-functionalized NFCs tested reduced cell viability and triggered pro-inflammatory reactions <i>in vitro</i>. In contrast, all cellulose materials induced innate immunity response <i>in vivo</i> 24 h after oropharyngeal aspiration, and the non-functionalized NFCs additionally caused features of Th2-type inflammation. Modest immune reactions were also seen after 28 days, however, the effects were markedly attenuated as compared with the ones after 24 h. Cellulose materials were not cleared within 1 month, as demonstrated by their presence in the exposed lungs. All effects of NFC were modest as compared with those induced by rCNT. NFC-induced responses were similar or exceeded those triggered by bulk-sized cellulose. These data provide new information about the biodurability and pulmonary effects of different NFCs; this knowledge can be useful in the risk assessment of cellulose materials.