cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.22353367
title: Supplementary Material for: Breastfeeding success and newborn health before and during the COVID-19 pandemic: a single centre comparative study

description: Introduction: Due to the SARS-CoV-2 pandemic, adjustments in patient and visitor traffic were made in hospitals to limit viral exposure. The primary objective of our study was to compare the breastfeeding success of healthy newborns in a maternity ward during the 2020 lockdown period compared with the same period in the previous year. Material and methods: single-center comparative study based on prospectively collected data. All neonates born alive, from a single pregnancy, and with a gestational age greater than 36 weeks were considered for this study. Results: 309 infants born in 2020 and 330 born in 2019 were included. Among women who desired to exclusively breastfeed, the rate of exclusive breastfeeding at discharge from the maternity ward was higher in 2020 than in 2019 (85% vs. 79%; p=0.078). After logistic regression analysis adjusted for potential confounders (i.e., maternal BMI, parity, mode of delivery, gestational age, and size at birth), study period remained significantly and independently associated with exclusive breastfeeding at discharge(OR [95%IC] = 1.645 [1.005; 2.694]; p=0.046). Newborns born in 2020 were less likely to have weight loss ≥10% than those born in 2019 (OR [95%IC] = 2.596 [1.148; 5.872]; p=0.017) but had similar need for phototherapy (p=0.41). Conclusion: The success of exclusive breastfeeding during the 2020 lockdown period was increased compared with the same period in 2019.
DOI: 10.6084/m9.figshare.23294726
title: Supplementary Material for: Impact of Pulmonary Hypertension Hemodynamic Phenotype on Incident Atrial Fibrillation

description: Introduction: Atrial fibrillation/flutter (AF) is common among patients with pulmonary hypertension (PH) and is associated with poor clinical outcomes. AF has been shown to occur more commonly among patients with post-capillary PH, although AF also occurs among patients with pre-capillary PH. The goal of this study was to evaluate the independent impact of PH hemodynamic phenotype on incident AF among patients with PH. Methods: We retrospectively identified 262 consecutive patients, without a prior diagnosis of atrial arrhythmias, seen at the PH clinic at Mayo Clinic, Florida, between 1997 and 2017, who had right heart catheterization (RHC) and echocardiography performed, with follow-up for outcomes through 2021. Kaplan-Meier analysis and Cox-proportional hazards regression modeling were used to evaluate the independent effect of PH hemodynamic phenotype on incident AF. Results: Our study population was classified into two broad PH hemodynamic groups: pre-capillary (64.9%) and post-capillary (35.1%). The median age was 59.5 years (Q1: 48.4, Q3: 68.4), and 72% were female. In crude models, post-capillary PH was significantly associated with incident AF (HR 2.17, 95% CI: 1.26 – 3.74, p=0.005). This association was lost following multivariable adjustment, whereas left atrial volume index remained independently associated with incident AF (aHR 1.30, 95% CI: 1.09 – 1.54, p=0.003). Conclusion: We found PH hemodynamic phenotype was not significantly associated with incident AF in our patient sample, however, echocardiographic evidence of left atrial remodeling appeared to have a greater impact on AF development. Larger studies are needed to validate these findings and identify potential modifiable risk factors for AF in this population.
DOI: 10.6084/m9.figshare.23622735
title: Supplementary Material for: Hydroxychloroquine Attenuates <i>hERG</i> Channel by Promoting the Membrane Channel Degradation: Computational Simulation and Experimental Evidence for QT-Interval Prolongation with Hydroxychloroquine Treatment

description: <b><i>Introduction:</i></b> The coronavirus disease 2019 (COVID-19) pandemic has led to millions of confirmed cases and deaths worldwide and has no approved therapy. Currently, more than 700 drugs are tested in the COVID-19 clinical trials, and full evaluation of their cardiotoxicity risks is in high demand. <b><i>Methods:</i></b> We mainly focused on hydroxychloroquine (HCQ), one of the most concerned drugs for COVID-19 therapy, and investigated the effects and underlying mechanisms of HCQ on <i>hERG</i> channel via molecular docking simulations. We further applied the HEK293 cell line stably expressing <i>hERG</i>-wild-type channel (<i>hERG</i>-HEK) and HEK293 cells transiently expressing <i>hERG</i>-p.Y652A or <i>hERG</i>-p.F656A mutants to validate our predictions. Western blot analysis was used to determine the <i>hERG</i> channel, and the whole-cell patch clamp was utilized to record <i>hERG</i> current (<i>I</i><sub>hERG</sub>). <b><i>Results:</i></b> HCQ reduced the mature <i>hERG</i> protein in a time- and concentration-dependent manner. Correspondingly, chronic and acute treatment of HCQ decreased the <i>hERG</i> current. Treatment with brefeldin A (BFA) and HCQ combination reduced <i>hERG</i> protein to a greater extent than BFA alone. Moreover, disruption of the typical <i>hERG</i> binding site (<i>hERG</i>-p.Y652A or <i>hERG</i>-p.F656A) rescued HCQ-mediated <i>hERG</i> protein and <i>I</i><sub>hERG</sub> reduction. <b><i>Conclusion:</i></b> HCQ can reduce the mature <i>hERG</i> channel expression and <i>I</i><sub>hERG</sub> via enhancing channel degradation. The QT prolongation effect of HCQ is mediated by typical <i>hERG</i> binding sites involving residues Tyr652 and Phe656.
DOI: 10.5281/zenodo.7787640
title: Datasets used for the publication: UAV-Lidar reveals that canopy structure mediates the influence of edge effects on forest diversity, function and microclimate

description: Datasets used for the publication: UAV-Lidar reveals that canopy structure mediates the influence of edge effects on forest diversity, function and microclimate. The file "Blanchard_et_al_JoE_2023_data_plot_trees.csv" contains individual tree indentification data for the 46 plots used in the study. The file "Blanchard_et_al_JoE_2023_data_plot_aggregated.csv" contains plot-level aggregated metrics used for the analyses: - distance to the forest edge - diversity indices : the 20-sp rarefied species richness "rar_sp_richness_20" and the 20-sp rarefied Beta diversity "Beta_div" which corresponds to the plos coordinates on the PCoA first axis. - functional indices: the community weighted mean trait values for the four traits used in this study : ,"WD","SLA","LA","LDMC"; the fonctional divergence index "FD_trans.FDiv"; and the synthetic community weigthed mean trait wich corresponds to the postion on plots on the principal component analysis of species trait values "Functional_composition_trans". Note that the SLA and LA values were log-transformed before computing "FD_trans.FDiv" and "Functional_composition_trans". - UAV-LiDAR-dervived metrics: canopy height, gap fraction ("gap_fraction2"), slope, curvature - The estimated plot above graound biomass "agb_plot", and the mean value of the vapor pressure deficit during the drisest month "max_monthly_VPD". - coordinates of the plots in UTM 58S (Coordinate reference system) Please read the material and method section of the article for more informations on this dataset.
DOI: 10.5281/zenodo.7950835
title: koki-u/3d_microscope-: Kerr microscope

description: No description provided.
DOI: 10.15468/1p0dgw
title: Diversity of small Amazonian Dendropsophus (Anura: Hylidae): another new species from northern Bolivia

description: This dataset contains the digitized treatments in Plazi based on the original journal article Moravec, Ji Ř Í, Aparicio, James, Guerrero-Reinhard, Marcelo, Calderon, Gonzalo, Köhler, Jörn (2008): Diversity of small Amazonian Dendropsophus (Anura: Hylidae): another new species from northern Bolivia. Zootaxa 1918: 1-12, DOI: 10.5281/zenodo.184655
DOI: 10.5066/p9pt6dyc
title: Spatial data of California riparian vegetation productivity trends over time (2000-2020) and environmental covariates

description: This data release contains a shapefile of riparian vegetation communities attributed with information on trends in satellite-estimates of vegetation productivity for the period from 2000-2020. Cloud-masked Landsat data were processed from 2000 to 2020 to generate a 21-year growing season (June, July, and August) time series combining data from Landsat 5 (2000-2011), Landsat 7 (2012), and Landsat 8 (2013-2020). We computed the near-infrared reflectance of vegetation (NIRv) which is strongly correlated to vegetation Gross Primary Productivity (GPP). We analyzed growing season time series trends in NIRv by riparian vegetation type at the polygon-level using the Theil-Sen estimator (aka Sen's slope). In addition to the vector dataset is a table containing climate, topographic and land use co-variates used to model the environmental drivers of riparian vegetation change.
DOI: 10.5281/zenodo.7713747
title: Training simulations for emulator fitting in study of landslide-generated tsunamis in the Makassar Strait

description: <strong>Training simulations used in the study titled 'Probabilistic landslide tsunami estimation in the Makassar Strait, Indonesia, using statistical emulation'</strong> Description: 'dem' directory - Bathymetric/Topographic data required to run simulations 'Simulation{1..50}' directories: eta.mp4 - video animation of wave propagation {1..50}.c and topics.h - code and header file for simulation etamax.dat - XYZ file of maximum surface elevation for simulation gauges directory - .dat files containing timeseries outputs for each gauge
DOI: 10.5281/zenodo.7942235
title: Supplementary material: Accuracy of finite fault slip estimates in subduction zone regions with topographic Green's functions and seafloor geodesy

description: # Code attached to the manuscript entitled "Accuracy of finite fault slip estimates in subduction zone regions with topographic Green's functions and seafloor geodesy" These python scripts are for producing Figure 1 (trench-perpendicular topographic profile for regions where some megathrust earthquakes occurred) and the average topographic profile that is used in the paper.
DOI: 10.5281/zenodo.7987515
title: Cropland area database by country circa 2020

description: This dataset describes a new estimate of cropland area circa the year 2020, with global coverage, with data for 221 countries and territories and 34 regional aggregates. Data are generated from geospatial information on the agreement-disagreement characteristics of six open access high-resolution cropland maps derived from remote sensing (ESRI LU/LC, FROM-GLC Plus, GLAD, GLC-FCS30, Globeland30 and Worldcover). This cropland area mapping (CAM) dataset provides information on: i) mean cropland area and its uncertainty; ii) cropland area by six distinct cropland agreement classes; and iii) cropland area by specific combinations of underlying land cover product. The file contains data on the mean cropland area obtained from 6 high resolution cropland layers and the corresponding standard error and the area for six simple cropland agreement classes are reported. Cropland area from the 6 high resolution land cover layers. And area of detailed agreement classes describing the cropland area for each combination of the land cover layers. For additional information a lookup table is included for the detailed agreement data, here you find an overview of the corresponding land cover layers that map cropland for each detailed agreement class. This dataset was generated from the cropland agreement map (Tubiello, 2022), previously used to estimate cropland areas across the world (Tubiello, 2023). The data was further used in an analysis of global cropland area in comparison with FAOSTAT cropland data. Tubiello, Francesco N., Conchedda, Giulia, Casse, Leon, Hao, Pengyu, Chen, Zhongxin, De Santis, Giorgia, Fritz, Steffen, & Muchoney, Douglas. (2022). High resolution cropland agreement map (30 m) circa 2020 (v1.0) [Data set]. Zenodo. https://doi.org/10.5281/zenodo.7244124 Tubiello, F.N., Conchedda, G., Casse, L. et al. Measuring the world’s cropland area. Nat Food 4, 30–32 (2023). https://doi.org/10.1038/s43016-022-00667-9
DOI: 10.6073/pasta/97f8092c10aecbc62aec12557ecb52bd
title: Forest structural diversity at NEON sites in the continuous USA that experienced recent moderate disturbance

description: Disturbances can change the structural diversity of forests through time, which can be measured from three-dimensional data provided by LiDAR. Discrete-return LiDAR was used to measure a suite of 19 structural diversity metrics that describe the height, cover and openness, vegetation density, and internal and external heterogeneity of forest vegetation at NEON base plots. Discrete-return LiDAR point clouds from the NEON Aerial Observation Platform (DP1.30003.001) were downloaded September of 2020 and used to estimate the metrics within 40 x 40 m base plots. Metrics were estimated from base plots at 15 NEON forested sites from provisional LiDAR data available from 2014 to 2020. The workflow that produced the data was developed in the program R.
DOI: 10.6084/m9.figshare.21564030.v1
title: Data for ALS analysis of moose on forest structure across a network of exclosures in boreal forests

description: This dataset includes (1) metadata for a network of moose exclosures across the boreal biome (2) a metadata template that describes the variables in the metadata. (3) LIDAR metrics calculated for each open plot and exclosure. Note that the coordinates of the exclosures in Finland are withheld due to conservation concerns. Contact Jari Kouki for details regarding these.
DOI: 10.6084/m9.figshare.22274581
title: Supplementary Material for: Fetal High-Risk APOL1 Genotype Increases Risk for Small for Gestational Age in Term Infants Affected by Preeclampsia.

description: Background: Hypertensive disorders of pregnancy cause fetal growth restriction and increased maternal morbidity and mortality, especially in women of African ancestry. Recently, preeclampsia (PE) risk was linked with African polymorphisms in the Apolipoprotein L1 (APOL1) gene. Objectives: We assessed the effect of APOL1 genotype on fetal growth outcomes of pregnancies with and without PE. Method: We conducted an unmatched case-control study of 1,358 mother-infant pairs from two independent cohorts of Black women. Results: Term PE cases with high-risk APOL1 genotypes were more likely to be small for gestational age compared to APOL1 low-risk term cases or APOL1 high-risk controls (odds ratios of 2.8 and 5.5, respectively). Among preterm cases, APOL1 genotype was associated with PE, significant for both recessive and additive inheritance patterns. Conclusions: Fetal APOL1 genotype was associated with PE in preterm infants but altered fetal growth in term infants indicating APOL1 genotype impacts conditions associated with placental insufficiency.
DOI: 10.6084/m9.figshare.22340392
title: Supplementary Material for: Depression Risk in Post-stroke Aphasia Patients: A Nationwide Population-Based Cohort Study

description: Introduction: Depression and aphasia impair the quality of life after a stroke. Studies linking depression risk to post-stroke aphasia (PSA) lacked confirmation using a large database. Methods: Using Taiwan's National Health Insurance claims data, we identified ≥18 years old patients hospitalized for stroke from 2005 to 2009, and those diagnosed with aphasia during hospitalization or within three months after discharge were selected to form the aphasic group. We estimated depression incidence by December 31, 2018, and used the Cox proportional hazards model to estimate aphasia group to non-aphasia group hazard ratios (HRs). Results: With a median follow-up period of 7.91 and 8.62 years for aphasia (n=26,754) and non-aphasia groups (n=139,102), respectively, the incidence of depression was higher in the aphasia group than in the non-aphasia group (9.02 vs.8.13 per 1000 person-years), with an adjusted HR (95% confidence intervals, CI) of 1.21 (1.15-1.29) for depression. The adjusted HRs [95% CI] of depression were homogenous for females, 1.26 [1.15-1.37] and for males, 1.18 [1.09-1.27] and for hemorrhagic stroke, 1.22 [1.09-1.37] and ischemic stroke, 1.21 [1.13-1.30]. Results in analyzing 25939 propensity score matched pairs demonstrated an equivalent effect. Conclusion: Patients with PSA are at an increased risk of developing depression regardless of sex or stroke type.
DOI: 10.6084/m9.figshare.22434031
title: Supplementary Material for: Association between Endotype of Prematurity and Mortality: A Systematic Review, Meta-analysis and Meta-regression

description: Introduction Preterm birth represents the leading cause of neonatal mortality. Pathophysiological pathways, or endotypes, leading to prematurity can be clustered into infection/inflammation and dysfunctional placentation. We aimed to perform a systematic review and meta-analysis exploring the association between these endotypes and risk of mortality during first hospital admission. Methods PROSPERO ID: CRD42020184843. PubMed and Embase were searched for observational studies examining infants with gestational age (GA) ≤34 weeks. Chorioamnionitis represented the infectious-inflammatory endotype, while dysfunctional placentation proxies were hypertensive disorders of pregnancy (HDP) and small for GA (SGA)/intrauterine growth restriction (IUGR). A random-effects model was used to calculate odds ratios (ORs) and 95% confidence intervals (CIs). Heterogeneity was studied using random-effects meta-regression analysis. Results Of 4322 potentially relevant studies, 150 (612,580 infants) were included. Meta- analysis showed a positive mortality odds for chorioamnionitis (OR 1.43, 95% CI 1.25-1.62) and SGA/IUGR (OR 1.68, 95% CI 1.38-2.04), but a negative mortality odds for HDP (OR 0.74, 95% CI 0.64-0.86). Chorioamnionitis was associated with a lower GA, while HDP and SGA/IUGR were associated with a higher GA. Meta-regression showed a significant correlation between these differences in GA and mortality odds. Discussion/Conclusion Our data suggest that the infectious/inflammatory endotype of prematurity has a greater overall impact on mortality risk as it is the most frequent endotype in the lower GAs. However, when the endotype of placental dysfunction is severe enough to induce growth restriction, it is strongly associated with higher mortality rates even though newborns are more mature.
DOI: 10.6084/m9.figshare.22550173
title: Supplementary Material for: Analysis of fractional cerebral oxygen extraction in preterm infants during the kangaroo care.

description: Introduction: We aimed to investigate the cerebral fractional tissue oxygen extraction (FtOE) during kangaroo care (KC) in premature infants and compare cardiorespiratory stability and hypoxic or bradycardic events between KC and incubator care. Methods: A single center prospective observational study was carried out at the NICU of a level III perinatal center. Preterm infants &lt; 32 weeks gestational age were subjected to KC. Patients were subjected to continuous monitoring of regional cerebral oxygen saturation (rScO2), peripheral oxygen saturation (SpO2), and heart rate (HR) during KC, before KC (pre-KC), and after KC (post-KC). The monitoring data were stored and exported to MATLAB for synchronization and signal analysis including the calculation of the FtOE and events analysis (i.e., desaturations and bradycardias counts and anormal values). Furthermore, the event counts and the mean SpO2, HR, rScO2, and FtOE were compared between studied periods employing the Wilcoxon rank-sum test and the Friedman test, respectively. Results: A total of forty-three KC sessions with their corresponding pre-KC and post-KC segments were analyzed. The distributions of the SpO2, HR, rScO2, and FtOE showed different patterns according to the respiratory support, but not differences between the studied periods were detected. Accordingly, no significant differences in monitoring events were evidenced. However, cerebral metabolic demand (FtOE) was significantly lower during KC compared with post-KC (p=0.019). Discussion/Conclusion: Premature infants remain clinically stable during KC. Moreover, cerebral oxygenation is significantly higher and cerebral tissular oxygen extraction is significantly lower during KC compared with incubator care in post-KC. No differences in HR and SpO2 were shown. This novel data analysis methodology could be expanded to other clinical situations.
DOI: 10.6084/m9.figshare.22682191
title: Supplementary Material for: Safety and Efficacy of Ticagrelor versus Clopidogrel in East Asian Patients with Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention Treated with Dual Antiplatelet Therapy: A Meta-Analysis of Randomized Controlled Trials

description: Introduction: The treatment strategy for dual antiplatelet therapy (DAPT) with ticagrelor has been controversial in East Asian patients with acute coronary syndrome (ACS) undergoing percutaneous coronary intervention (PCI). Our meta-analysis aimed to demonstrate whether intensified antithrombotic regimens with ticagrelor plus aspirin have more beneficial effects and fewer adverse events compared to those of clopidogrel plus aspirin in East Asian patients with ACS undergoing PCI. Methods: We searched PubMed, Embase, Web of Science, Science Direct, Clinical Trial, Cochrane Library, and Chinese Clinical Trial Registry for randomized controlled trials (RCTs) comparing the efficacy of DAPT with ticagrelor or clopidogrel plus aspirin for secondary prevention of ACS in East Asian patients undergoing PCI. Risk ratios (RR) and 95% confidence intervals (CIs) were used as the metrics of choice for assessing treatment effect. The primary endpoint was bleeding events, and the secondary endpoints were major adverse cardiovascular and cerebrovascular events (MACCE, including cardiovascular death, non-fatal myocardial infarction, and stroke), all-cause death, and definite/probable/possible stent thrombosis. The I² index was used to assess heterogeneity. Results: Six RCTs involving a total of 2,725 patients met the inclusion criteria. The incidence of all bleeding events with ticagrelor was higher than that with clopidogrel (RR, 1.65; 95%CI, 1.31–2.07), but the incidence of MACCE was not significantly different between the two groups (RR, 1.08; 95%CI, 0.54–2.16). All-cause death (RR, 1.10; 95%CI, 0.67–1.79), cardiovascular death (RR, 1.42; 95%CI, 0.68–2.98), non-fatal MI (RR, 0.92; 95%CI, 0.48–1.78), stroke (RR,1.00; 95%CI, 0.40–2.50), and stent thrombosis (RR, 0.76; 95%CI, 0.19-2.98) were not statistically different between the two groups. Conclusion: Ticagrelor increased the risk of bleeding and did not increase treatment efficacy compared to that of clopidogrel in the East Asian population who have ACS treated with PCI.