cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.6151307
title: Radiation therapy for oral melanoma in dogs: A retrospective study

description: ABSTRACT: Our retrospective study evaluated the survival of 24 dogs with unresectable malignant melanoma treated with radiation therapy. Fifteen dogs were treated with radiation therapy (RT) and chemotherapy (CT), five with surgery followed by RT and CT, three with palliative RT, and one with electrochemotherapy associated with RT. All dogs were treated with an orthovoltage Stabilipan I. The protocol used was three or four weekly fractions of 8 Gy. Carboplatin was administered every 21 days, a total of four times. Five percent of dogs were classified as having stage I melanoma, 17% as stage II, 50% as stage III, and 17% as stage IV. Sixty-four percent had a partial response to treatment, 29% achieved complete remission, and 7% remained in a stable disease state. The mean survival time was 390 days for stage I, 286 days for stage II, 159 days for stage III, and 90 days for stage IV. We concluded that radiation therapy can be considered a viable alternative for the palliative treatment of canine oral melanoma.
DOI: 10.6084/m9.figshare.6151304
title: DETERMINING PRODUCTION AND INVENTORY PARAMETERS: AN INTEGRATED SIMULATION AND MAVT APPROACH WITH TRADEOFF ELICITATION

description: ABSTRACT This study puts forward a multi-attribute decision model that determines good production and inventory parameter settings in make-to-stock (MTS) environments controlled by the Conwip (constant work-in-process) method. This model uses a discrete event simulation to evaluate the performance of a system in relation to work-in-process and a finished goods inventory. Based on Multi-Attribute Value Theory (MAVT), a compromise solution is found by taking into account the decision-maker’s preferences and tradeoff judgments as to the attributes of cycle time, throughput rate, holding cost and stockout cost. A numerical application is given to illustrate the use of the proposed multi-attribute model which includes a sensitivity analysis.
DOI: 10.6084/m9.figshare.6151307.v1
title: Radiation therapy for oral melanoma in dogs: A retrospective study

description: ABSTRACT: Our retrospective study evaluated the survival of 24 dogs with unresectable malignant melanoma treated with radiation therapy. Fifteen dogs were treated with radiation therapy (RT) and chemotherapy (CT), five with surgery followed by RT and CT, three with palliative RT, and one with electrochemotherapy associated with RT. All dogs were treated with an orthovoltage Stabilipan I. The protocol used was three or four weekly fractions of 8 Gy. Carboplatin was administered every 21 days, a total of four times. Five percent of dogs were classified as having stage I melanoma, 17% as stage II, 50% as stage III, and 17% as stage IV. Sixty-four percent had a partial response to treatment, 29% achieved complete remission, and 7% remained in a stable disease state. The mean survival time was 390 days for stage I, 286 days for stage II, 159 days for stage III, and 90 days for stage IV. We concluded that radiation therapy can be considered a viable alternative for the palliative treatment of canine oral melanoma.
DOI: 10.6084/m9.figshare.6151304.v1
title: DETERMINING PRODUCTION AND INVENTORY PARAMETERS: AN INTEGRATED SIMULATION AND MAVT APPROACH WITH TRADEOFF ELICITATION

description: ABSTRACT This study puts forward a multi-attribute decision model that determines good production and inventory parameter settings in make-to-stock (MTS) environments controlled by the Conwip (constant work-in-process) method. This model uses a discrete event simulation to evaluate the performance of a system in relation to work-in-process and a finished goods inventory. Based on Multi-Attribute Value Theory (MAVT), a compromise solution is found by taking into account the decision-maker’s preferences and tradeoff judgments as to the attributes of cycle time, throughput rate, holding cost and stockout cost. A numerical application is given to illustrate the use of the proposed multi-attribute model which includes a sensitivity analysis.
DOI: 10.6084/m9.figshare.6151301
title: Ecological drivers of plant genetic diversity at the southern edge of geographical distributions: Forestal vines in a temperate region

description: Abstract The Tropical Niche Conservatism hypothesis is one of the most relevant theories to explain why tropical diversity is high, although the mechanisms underlying this hypothesis require further clarification. A possible research avenue to address the underlying mechanisms includes determining population-level processes associated with such a hypothesis, in particular by trying to identify how adaptation may occur in extreme niche conditions at the edges of species ranges. However, the determinants of molecular diversity at the edges of geographical distributions of tropical taxa are still poorly known. Here we assessed which environmental variables determine diversity in nuclear and plastid genetic markers for populations of four Passiflora species in the southern limit of their geographical distributions. Climatic factors can drive genetic diversity, and their importance varies according to the marker. The primary predictors are variables representing higher temperatures during cold periods of the year and higher precipitation during dry periods. We concluded that, although these species are present in colder areas at the edge of their range, Tropical Niche Conservatism acts as a restraining force on genetic diversity in southern populations of Passiflora.
DOI: 10.6084/m9.figshare.6151301.v1
title: Ecological drivers of plant genetic diversity at the southern edge of geographical distributions: Forestal vines in a temperate region

description: Abstract The Tropical Niche Conservatism hypothesis is one of the most relevant theories to explain why tropical diversity is high, although the mechanisms underlying this hypothesis require further clarification. A possible research avenue to address the underlying mechanisms includes determining population-level processes associated with such a hypothesis, in particular by trying to identify how adaptation may occur in extreme niche conditions at the edges of species ranges. However, the determinants of molecular diversity at the edges of geographical distributions of tropical taxa are still poorly known. Here we assessed which environmental variables determine diversity in nuclear and plastid genetic markers for populations of four Passiflora species in the southern limit of their geographical distributions. Climatic factors can drive genetic diversity, and their importance varies according to the marker. The primary predictors are variables representing higher temperatures during cold periods of the year and higher precipitation during dry periods. We concluded that, although these species are present in colder areas at the edge of their range, Tropical Niche Conservatism acts as a restraining force on genetic diversity in southern populations of Passiflora.
DOI: 10.6084/m9.figshare.6151298
title: PERFORMANCE COMPARISON OF SCENARIO-GENERATION METHODS APPLIED TO A STOCHASTIC OPTIMIZATION ASSET-LIABILITY MANAGEMENT MODEL

description: ABSTRACT In this paper, we provide an empirical discussion of the differences among some scenario tree-generation approaches for stochastic programming. We consider the classical Monte Carlo sampling and Moment matching methods. Moreover, we test the Resampled average approximation, which is an adaptation of Monte Carlo sampling and Monte Carlo with naive allocation strategy as the benchmark. We test the empirical effects of each approach on the stability of the problem objective function and initial portfolio allocation, using a multistage stochastic chance-constrained asset-liability management (ALM) model as the application. The Moment matching and Resampled average approximation are more stable than the other two strategies.
DOI: 10.6084/m9.figshare.6151298.v1
title: PERFORMANCE COMPARISON OF SCENARIO-GENERATION METHODS APPLIED TO A STOCHASTIC OPTIMIZATION ASSET-LIABILITY MANAGEMENT MODEL

description: ABSTRACT In this paper, we provide an empirical discussion of the differences among some scenario tree-generation approaches for stochastic programming. We consider the classical Monte Carlo sampling and Moment matching methods. Moreover, we test the Resampled average approximation, which is an adaptation of Monte Carlo sampling and Monte Carlo with naive allocation strategy as the benchmark. We test the empirical effects of each approach on the stability of the problem objective function and initial portfolio allocation, using a multistage stochastic chance-constrained asset-liability management (ALM) model as the application. The Moment matching and Resampled average approximation are more stable than the other two strategies.
DOI: 10.6084/m9.figshare.6151292
title: Acoustic Birefringence and Poisson's Ratio Determined by Ultrasound: Tools to Follow-Up Deformation by Cold Rolling and Recrystallization

description: Poisson's ratio and birefringence, both measured by ultrasound, are used to follow the evolution of the anisotropy in ASTM A-36 steel plates cold-rolled between 5 and 50% deformation, and then subjected to recrystallization at 900 and 1000 ºC. Times of flight of longitudinal and shear waves along the thickness of the plates were measured. As orthotropy increases, both birefringence and the difference between Poisson's ratios measured using a shear wave polarized along the length and another wave polarized along the width of the plate, are linearly related to the degree of deformation and cold-rolled hardness. In addition, the ultrasonic methods used clearly detected the complex changes in anisotropy produced by the austenization and recrystallization heat treatments. Thus, Birefringence or Poisson's ratio, measured by ultrasound, can be used to follow-up nondestructively changes in the anisotropy of rolled plates as a function of both, degree of deformation and recrystallization heat treatment.
DOI: 10.6084/m9.figshare.6151292.v1
title: Acoustic Birefringence and Poisson's Ratio Determined by Ultrasound: Tools to Follow-Up Deformation by Cold Rolling and Recrystallization

description: Poisson's ratio and birefringence, both measured by ultrasound, are used to follow the evolution of the anisotropy in ASTM A-36 steel plates cold-rolled between 5 and 50% deformation, and then subjected to recrystallization at 900 and 1000 ºC. Times of flight of longitudinal and shear waves along the thickness of the plates were measured. As orthotropy increases, both birefringence and the difference between Poisson's ratios measured using a shear wave polarized along the length and another wave polarized along the width of the plate, are linearly related to the degree of deformation and cold-rolled hardness. In addition, the ultrasonic methods used clearly detected the complex changes in anisotropy produced by the austenization and recrystallization heat treatments. Thus, Birefringence or Poisson's ratio, measured by ultrasound, can be used to follow-up nondestructively changes in the anisotropy of rolled plates as a function of both, degree of deformation and recrystallization heat treatment.
DOI: 10.6084/m9.figshare.6151289
title: Quality and antioxidant potential of byproducts from refining of fruit pulp

description: Abstract The potential use of byproducts from fruit processing has been evaluated in order to propose new uses as well as reducing costs and environmental impact. Most of the studies are focused on byproducts from primary transformation. However, byproducts from secondary transformation can reserve similar reuse opportunities. The aim of this study was to characterize chemical composition and antioxidant capacity that remained on byproducts from fruit processing at the pulp refinement stage. The byproducts from pulp refining were evaluated in cashew, cocoa, cupuassu, genipap, papaya, passion fruit seed, plum, soursop (pulp and seeds), strawberry, tamarind (pulp and seeds), umbu and yellow mombin fruits. Water activity, acidity, pH, soluble solids, sugars, starch, pectins, ascorbic acid, carotenoids and polyphenols, and the antioxidant activity were analyzed. The byproducts from the refinement of soursop related to the fibrous pulp showed the highest soluble solids and pectic compounds content, while the seeds byproducts constituted a source of starch. The byproducts from the refining of pulp from yellow mombin and papaya were sources of carotenoids. The highest starch and polyphenols contents, as well as antioxidant activities peak on the refining of byproducts of tamarind. The byproducts studied maintained chemical compounds and bioactive components that hold potential reuse.
DOI: 10.6084/m9.figshare.6151289.v1
title: Quality and antioxidant potential of byproducts from refining of fruit pulp

description: Abstract The potential use of byproducts from fruit processing has been evaluated in order to propose new uses as well as reducing costs and environmental impact. Most of the studies are focused on byproducts from primary transformation. However, byproducts from secondary transformation can reserve similar reuse opportunities. The aim of this study was to characterize chemical composition and antioxidant capacity that remained on byproducts from fruit processing at the pulp refinement stage. The byproducts from pulp refining were evaluated in cashew, cocoa, cupuassu, genipap, papaya, passion fruit seed, plum, soursop (pulp and seeds), strawberry, tamarind (pulp and seeds), umbu and yellow mombin fruits. Water activity, acidity, pH, soluble solids, sugars, starch, pectins, ascorbic acid, carotenoids and polyphenols, and the antioxidant activity were analyzed. The byproducts from the refinement of soursop related to the fibrous pulp showed the highest soluble solids and pectic compounds content, while the seeds byproducts constituted a source of starch. The byproducts from the refining of pulp from yellow mombin and papaya were sources of carotenoids. The highest starch and polyphenols contents, as well as antioxidant activities peak on the refining of byproducts of tamarind. The byproducts studied maintained chemical compounds and bioactive components that hold potential reuse.
DOI: 10.6084/m9.figshare.6151286
title: Identification of microRNA signature in different pediatric brain tumors

description: Abstract Understanding pediatric brain tumor biology is essential to help on disease stratification, and to find novel markers for early diagnosis. MicroRNA (miRNA) expression has been linked to clinical outcomes and tumor biology. Here, we aimed to detect the expression of different miRNAs in different pediatric brain tumor subtypes to discover biomarkers for early detection and develop novel therapies. Expression of 82 miRNAs was detected in 120 pediatric brain tumors from fixed-formalin paraffin-embedded tissues, low-grade glioma, high-grade glioma, ependymoma, and medulloblastoma, using quantitative real-time PCR. Low-expression of miR-221, miR-9, and miR-181c/d and over-expression of miR-101, miR-222, miR-139, miR-1827, and miR-34c was found in medulloblastoma; low expression of miR-10a and over-expression of miR-10b and miR-29a in ependymoma; low expression of miR-26a and overexpression of miR-19a/b, miR-24, miR-27a, miR- 584, and miR-527 in low-grade glioma. Cox regression showed differential miRNA expression between responders and non-responders. The most specific were miR-10a and miR-29a low expression in LGG non-responders, miR-135a and miR-146b over-expression in ependymoma non-responders, and miR-135b overexpression in medulloblastoma non-responders. MicroRNAs are differentially expressed in subtypes of brain tumors suggesting that they may help diagnosis. A greater understanding of aberrant miRNA in pediatric brain tumors may support development of novel therapies.
DOI: 10.6084/m9.figshare.6151283
title: Comparative Study About Mechanical Properties of Strutural Standard Concrete and Concrete with Addition of Vegetable Fibers

description: This paper explored the effect of adding organic fibers from either bamboo or sugarcane on the mechanical properties of concrete. Cylindrical and prismatic specimens were made containing 2% and 5% v/w (volume to weight) of vegetable fibers to concrete. Following 28 days of curing period, the samples were evaluated for compressive strength, tensile strength using diametric compression, tensile strength during bending and static modulus. It was discovered that all concretes produced met the minimum strength of 20 MPa recommended by NBR 6118 for structural purposes, and it was observed an increase of the compressive strength on the specimens with addition of organic fibers. Moreover, an increase in the compressive strength was observed in the specimens with fiber addition, although no significant variation of water absorption was noticed when compared with the standard concrete. In conclusion, the concrete containing 2% v/w of bamboo fibers showed better mechanical strength and static modulus of elasticity when compared to both concrete with sugar cane fibers addition and the concrete without any additional fibers.
DOI: 10.6084/m9.figshare.6151286.v1
title: Identification of microRNA signature in different pediatric brain tumors

description: Abstract Understanding pediatric brain tumor biology is essential to help on disease stratification, and to find novel markers for early diagnosis. MicroRNA (miRNA) expression has been linked to clinical outcomes and tumor biology. Here, we aimed to detect the expression of different miRNAs in different pediatric brain tumor subtypes to discover biomarkers for early detection and develop novel therapies. Expression of 82 miRNAs was detected in 120 pediatric brain tumors from fixed-formalin paraffin-embedded tissues, low-grade glioma, high-grade glioma, ependymoma, and medulloblastoma, using quantitative real-time PCR. Low-expression of miR-221, miR-9, and miR-181c/d and over-expression of miR-101, miR-222, miR-139, miR-1827, and miR-34c was found in medulloblastoma; low expression of miR-10a and over-expression of miR-10b and miR-29a in ependymoma; low expression of miR-26a and overexpression of miR-19a/b, miR-24, miR-27a, miR- 584, and miR-527 in low-grade glioma. Cox regression showed differential miRNA expression between responders and non-responders. The most specific were miR-10a and miR-29a low expression in LGG non-responders, miR-135a and miR-146b over-expression in ependymoma non-responders, and miR-135b overexpression in medulloblastoma non-responders. MicroRNAs are differentially expressed in subtypes of brain tumors suggesting that they may help diagnosis. A greater understanding of aberrant miRNA in pediatric brain tumors may support development of novel therapies.
DOI: 10.6084/m9.figshare.6151283.v1
title: Comparative Study About Mechanical Properties of Strutural Standard Concrete and Concrete with Addition of Vegetable Fibers

description: This paper explored the effect of adding organic fibers from either bamboo or sugarcane on the mechanical properties of concrete. Cylindrical and prismatic specimens were made containing 2% and 5% v/w (volume to weight) of vegetable fibers to concrete. Following 28 days of curing period, the samples were evaluated for compressive strength, tensile strength using diametric compression, tensile strength during bending and static modulus. It was discovered that all concretes produced met the minimum strength of 20 MPa recommended by NBR 6118 for structural purposes, and it was observed an increase of the compressive strength on the specimens with addition of organic fibers. Moreover, an increase in the compressive strength was observed in the specimens with fiber addition, although no significant variation of water absorption was noticed when compared with the standard concrete. In conclusion, the concrete containing 2% v/w of bamboo fibers showed better mechanical strength and static modulus of elasticity when compared to both concrete with sugar cane fibers addition and the concrete without any additional fibers.
DOI: 10.6084/m9.figshare.6151280
title: Kinetics Oxidation and Characterization of Cyclically Oxidized Layers at High Temperatures for FeMnSiCrNiCe and FeSiCrNi Alloys

description: Conventional stainless steels are used in cyclic oxidation, but the high amount of Cr and mainly Ni increase the price of these alloys. The objective of the present study was to assess the cyclic oxidation resistance of FeSiCrNi and FeMnSiCrNiCe alloys in comparison to AISI 304 and AISI 310 stainless steels by evaluating the oxidation kinetics and using characterization techniques to determine the oxides formed. The alloys were melted in induction furnaces and cast in sand molds. Cyclic oxidation tests were carried out in an automated oven in cycles of one hour for heating and maintenance at high temperature (850, 950 or 1050 °C) and 10 minutes for cooling. To characterize the oxidized layers, X-Ray Diffraction (XRD), Scanning Electron Microscopy (SEM) and Energy Dispersive X-Ray Spectroscopy (EDS) analysis were performed. The oxidation kinetics were determined. The results showed that the studied alloys presented better results than AISI 304 at 850 °C, but at 1050 °C, AISI 310 presented the best results. At 950 °C, the FeSiCrNi alloy presented layer detachment and FeMnSiCrNiCe presented a higher rate of mass variation than AISI 310, both without oxide detachment. For both alloys, formation of chromium and manganese oxides with parabolic rate of mass gain occurred.
DOI: 10.6084/m9.figshare.6151280.v1
title: Kinetics Oxidation and Characterization of Cyclically Oxidized Layers at High Temperatures for FeMnSiCrNiCe and FeSiCrNi Alloys

description: Conventional stainless steels are used in cyclic oxidation, but the high amount of Cr and mainly Ni increase the price of these alloys. The objective of the present study was to assess the cyclic oxidation resistance of FeSiCrNi and FeMnSiCrNiCe alloys in comparison to AISI 304 and AISI 310 stainless steels by evaluating the oxidation kinetics and using characterization techniques to determine the oxides formed. The alloys were melted in induction furnaces and cast in sand molds. Cyclic oxidation tests were carried out in an automated oven in cycles of one hour for heating and maintenance at high temperature (850, 950 or 1050 °C) and 10 minutes for cooling. To characterize the oxidized layers, X-Ray Diffraction (XRD), Scanning Electron Microscopy (SEM) and Energy Dispersive X-Ray Spectroscopy (EDS) analysis were performed. The oxidation kinetics were determined. The results showed that the studied alloys presented better results than AISI 304 at 850 °C, but at 1050 °C, AISI 310 presented the best results. At 950 °C, the FeSiCrNi alloy presented layer detachment and FeMnSiCrNiCe presented a higher rate of mass variation than AISI 310, both without oxide detachment. For both alloys, formation of chromium and manganese oxides with parabolic rate of mass gain occurred.