cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.30628399
title: Associations of dietary indices with risk of all-cause and cardiovascular mortality in hypertensive adults

description: Dietary patterns play a pivotal role in managing hypertension and preventing mortality. However, comparative studies on the effects of different dietary patterns on mortality risk in hypertensive patients remain limited. The aim of this study is to evaluate and compare the associations between six established dietary indices and mortality risk in this population. Utilizing data from the 2005–2018 NHANES, 13,230 hypertensive adults were included in the analysis. Six standardized dietary indices were employed, and the associations between these dietary patterns and mortality were analyzed using a weighted Cox proportional hazards model. Additionally, time trend analysis was conducted to examine changes in dietary patterns, while weighted quantile regression (WQS) was used to identify key dietary components contributing to mortality risk. Over a median follow-up of 8.3 years, a total of 2,420 deaths were recorded, including 637 due to cardiovascular diseases. Higher scores for AHEI, DASH, HEI-2020, MED, and MEDI were significantly associated with reduced risk of all-cause mortality, whereas a proinflammatory diet, reflected by elevated DII scores, was associated with increased risk. Only higher DASH index scores were independently associated with reduced cardiovascular mortality. Time trend analysis revealed a decline in adherence to DASH over the years, whereas MEDI scores slightly increased. WQS regression identified dairy products, whole grains, and fatty acids as key dietary components influencing mortality risk. Healthy dietary patterns markedly reduce all-cause mortality risk in hypertensive patients, with the DASH diet offering notable cardiovascular protection. These findings support personalized dietary interventions for hypertension management.
DOI: 10.6084/m9.figshare.30628399.v1
title: Associations of dietary indices with risk of all-cause and cardiovascular mortality in hypertensive adults

description: Dietary patterns play a pivotal role in managing hypertension and preventing mortality. However, comparative studies on the effects of different dietary patterns on mortality risk in hypertensive patients remain limited. The aim of this study is to evaluate and compare the associations between six established dietary indices and mortality risk in this population. Utilizing data from the 2005–2018 NHANES, 13,230 hypertensive adults were included in the analysis. Six standardized dietary indices were employed, and the associations between these dietary patterns and mortality were analyzed using a weighted Cox proportional hazards model. Additionally, time trend analysis was conducted to examine changes in dietary patterns, while weighted quantile regression (WQS) was used to identify key dietary components contributing to mortality risk. Over a median follow-up of 8.3 years, a total of 2,420 deaths were recorded, including 637 due to cardiovascular diseases. Higher scores for AHEI, DASH, HEI-2020, MED, and MEDI were significantly associated with reduced risk of all-cause mortality, whereas a proinflammatory diet, reflected by elevated DII scores, was associated with increased risk. Only higher DASH index scores were independently associated with reduced cardiovascular mortality. Time trend analysis revealed a decline in adherence to DASH over the years, whereas MEDI scores slightly increased. WQS regression identified dairy products, whole grains, and fatty acids as key dietary components influencing mortality risk. Healthy dietary patterns markedly reduce all-cause mortality risk in hypertensive patients, with the DASH diet offering notable cardiovascular protection. These findings support personalized dietary interventions for hypertension management.
DOI: 10.6084/m9.figshare.30890743
title: Prognostic and immunological implications of sialylation-associated gene signatures in hepatocellular carcinoma

description: The absence of effective biomarkers continues to limit early diagnostic accuracy and prognostic evaluation in patients with hepatocellular carcinoma (HCC). Aberrant sialylation (SI) has been demonstrated to contribute to therapeutic resistance and tumor progression. The aim of this investigation was to identify a sialylation-related gene (SRG) signature, evaluate its prognostic significance, and investigate associated immunological characteristics in HCC. Transcriptomic profiles and corresponding clinical data for patients with HCC were obtained from UCSC Xena, the International Cancer Genome Consortium (ICGC), and the Molecular Signatures Database (MsigDB). Differential expression analysis, Cox regression analysis modeling, and least absolute shrinkage and selection operator (LASSO) regression analysis were applied to identify independent prognostic markers and develop predictive models. The tumor immune microenvironment and its relationship with the identified SRGs were assessed by evaluating immune infiltration patterns. A gene co-expression network for the prognostic SRGs was constructed using GeneMANIA to identify potentially targetable signaling pathways. Four SRGs (<i>ST6GALNAC4</i>, <i>B4GALT5</i>, <i>B4GALNT1</i>, and <i>NEU1</i>) were significantly associated with the prognosis of patients with HCC. Prognostic models constructed using these genes demonstrated strong predictive performance. Notable differences were observed in immune cell populations and immune checkpoint expression between the high-risk and low-risk groups. Additionally, the half-maximal inhibitory concentration values for 101 therapeutic compounds varied between these groups. Lipopolysaccharide and sphingolipid metabolism were identified as key biological processes linked to tumor progression and modulation of the immune microenvironment. The four identified SRGs were significantly associated with clinical outcomes and immunological features in HCC. These findings provide a foundation for advancing early diagnostic strategies, refining prognostic assessments, and guiding personalized therapeutic approaches for patients with HCC.
DOI: 10.6084/m9.figshare.30890743.v1
title: Prognostic and immunological implications of sialylation-associated gene signatures in hepatocellular carcinoma

description: The absence of effective biomarkers continues to limit early diagnostic accuracy and prognostic evaluation in patients with hepatocellular carcinoma (HCC). Aberrant sialylation (SI) has been demonstrated to contribute to therapeutic resistance and tumor progression. The aim of this investigation was to identify a sialylation-related gene (SRG) signature, evaluate its prognostic significance, and investigate associated immunological characteristics in HCC. Transcriptomic profiles and corresponding clinical data for patients with HCC were obtained from UCSC Xena, the International Cancer Genome Consortium (ICGC), and the Molecular Signatures Database (MsigDB). Differential expression analysis, Cox regression analysis modeling, and least absolute shrinkage and selection operator (LASSO) regression analysis were applied to identify independent prognostic markers and develop predictive models. The tumor immune microenvironment and its relationship with the identified SRGs were assessed by evaluating immune infiltration patterns. A gene co-expression network for the prognostic SRGs was constructed using GeneMANIA to identify potentially targetable signaling pathways. Four SRGs (<i>ST6GALNAC4</i>, <i>B4GALT5</i>, <i>B4GALNT1</i>, and <i>NEU1</i>) were significantly associated with the prognosis of patients with HCC. Prognostic models constructed using these genes demonstrated strong predictive performance. Notable differences were observed in immune cell populations and immune checkpoint expression between the high-risk and low-risk groups. Additionally, the half-maximal inhibitory concentration values for 101 therapeutic compounds varied between these groups. Lipopolysaccharide and sphingolipid metabolism were identified as key biological processes linked to tumor progression and modulation of the immune microenvironment. The four identified SRGs were significantly associated with clinical outcomes and immunological features in HCC. These findings provide a foundation for advancing early diagnostic strategies, refining prognostic assessments, and guiding personalized therapeutic approaches for patients with HCC.
DOI: 10.6084/m9.figshare.28103538
title: Efficacy and safety of low-dose TBI combined MAC regimen for HSCT in high-risk AML patients with active disease

description: The management of high-risk acute myeloid leukaemia (AML) remains challenging, highlighting the need for innovative conditioning strategies beyond current regimens. In the present single-arm study, a FACT regimen comprised of low-dose total body irradiation (TBI) with fludarabine, cytarabine and cyclophosphamide was employed to treat cytogenetically high-risk AML patients exhibiting pre-transplant active disease. This clinical trial is registered in the Chinese Clinical Trial Registry with the registration number ChiCTR2000035111. In this study, 21 high-risk AML patients with pre-transplant disease statuses including primary induction failure, relapse and measurable residual disease positivity, were enrolled to undergo FACT conditioning. The FACT group demonstrated a 1-year non-relapse mortality (NRM) rate of 9.5%, indicating a similar level of safety and tolerability among the conditioning regimens. The estimated cumulative incidence of grade 2–4 acute graft-versus-host disease (GVHD) at one year was 30.7%. Additionally, the cumulative incidence of chronic GVHD was 36.0% at one year and increased to 43.0% at two years. The FACT regimen is an effective myeloablative conditioning (MAC) strategy for high-risk AML patients, potentially reducing relapse risk without increasing NRM, warranting further research.
DOI: 10.6084/m9.figshare.28103538.v1
title: Efficacy and safety of low-dose TBI combined MAC regimen for HSCT in high-risk AML patients with active disease

description: The management of high-risk acute myeloid leukaemia (AML) remains challenging, highlighting the need for innovative conditioning strategies beyond current regimens. In the present single-arm study, a FACT regimen comprised of low-dose total body irradiation (TBI) with fludarabine, cytarabine and cyclophosphamide was employed to treat cytogenetically high-risk AML patients exhibiting pre-transplant active disease. This clinical trial is registered in the Chinese Clinical Trial Registry with the registration number ChiCTR2000035111. In this study, 21 high-risk AML patients with pre-transplant disease statuses including primary induction failure, relapse and measurable residual disease positivity, were enrolled to undergo FACT conditioning. The FACT group demonstrated a 1-year non-relapse mortality (NRM) rate of 9.5%, indicating a similar level of safety and tolerability among the conditioning regimens. The estimated cumulative incidence of grade 2–4 acute graft-versus-host disease (GVHD) at one year was 30.7%. Additionally, the cumulative incidence of chronic GVHD was 36.0% at one year and increased to 43.0% at two years. The FACT regimen is an effective myeloablative conditioning (MAC) strategy for high-risk AML patients, potentially reducing relapse risk without increasing NRM, warranting further research.
DOI: 10.6084/m9.figshare.30293933
title: Efficacy and safety of different fixation methods for unstable anterior pelvic ring fractures: a Bayesian network meta-analysis

description: To evaluate the effectiveness and safety of treatment methods for unstable pelvic anterior ring fractures, aiming to provide new ideas for their treatment. We searched English databases including PubMed, Embase, Cochrane Library, and Web of Science, as well as Chinese databases CNKI, VIP, and Wanfang, with the search date up to September 10, 2024. The quality of the included studies was assessed using the Cochrane’s Risk of Bias Tool and the Newcastle-Ottawa Scale (NOS). The effectiveness and safety of different surgical fixation methods were ranked according to probability levels. A total of 17 studies involving 1010 patients were included. Compared to external fixation (ExFix), plating, screws, and internal fixator (INFIX) showed better reduction quality. Patients using plates had the highest likelihood of achieving anatomical reduction. Screw fixation was the most effective method for postoperative functional recovery. The screw group had the lowest incidence of deep vein thrombosis in the lower limbs. The plate fixation group had the lowest incidence of lateral femoral cutaneous nerve injury. In the treatment of unstable pelvic anterior ring fractures, plating, screws, and INFIX fixation can be selected, while ExFix should only be used as a temporary fixation method.
DOI: 10.6084/m9.figshare.30293933.v1
title: Efficacy and safety of different fixation methods for unstable anterior pelvic ring fractures: a Bayesian network meta-analysis

description: To evaluate the effectiveness and safety of treatment methods for unstable pelvic anterior ring fractures, aiming to provide new ideas for their treatment. We searched English databases including PubMed, Embase, Cochrane Library, and Web of Science, as well as Chinese databases CNKI, VIP, and Wanfang, with the search date up to September 10, 2024. The quality of the included studies was assessed using the Cochrane’s Risk of Bias Tool and the Newcastle-Ottawa Scale (NOS). The effectiveness and safety of different surgical fixation methods were ranked according to probability levels. A total of 17 studies involving 1010 patients were included. Compared to external fixation (ExFix), plating, screws, and internal fixator (INFIX) showed better reduction quality. Patients using plates had the highest likelihood of achieving anatomical reduction. Screw fixation was the most effective method for postoperative functional recovery. The screw group had the lowest incidence of deep vein thrombosis in the lower limbs. The plate fixation group had the lowest incidence of lateral femoral cutaneous nerve injury. In the treatment of unstable pelvic anterior ring fractures, plating, screws, and INFIX fixation can be selected, while ExFix should only be used as a temporary fixation method.
DOI: 10.6084/m9.figshare.28463563
title: Knowledge, attitudes and practices of pain management among Taiwanese physicians in a reformed 2-year postgraduate training programme: a cross-sectional questionnaire survey

description: Taiwan implemented a reformed 6-year medical education in 2013, with a subsequent 2-year postgraduate training programme starting in August 2019. This study investigated the perceptions of acute and chronic pain management in postgraduate physicians. In late July 2023, a cross-sectional questionnaire survey was conducted of Taiwanese physicians who had almost completed their postgraduate 2-year or 1-year training and those who were starting a postgraduate programme in early August 2023. This survey evaluated their knowledge, attitude and clinical experience related to opioid-based pain management and their perceptions of the opioid crisis in the United States and Taiwan. Of the 197 postgraduate physicians, 169 (85.8%) responded to the survey. Physicians who had received postgraduate 2-year (<i>n</i> = 48) and 1-year (<i>n</i> = 51) training had a deeper understanding of opioids (<i>p</i> &lt; 0.001) and exhibited greater confidence in acute and chronic pain management (both <i>p</i> &lt; 0.001) compared with those who were just starting a postgraduate programme (<i>n</i> = 70). Of the included physicians, 92 (54.4%) were aware of the ongoing opioid crisis in the United States, but only 28 (16.6%) disagreed with the notion of a current opioid problem in Taiwan. Approximately 27.8% had never heard of multimodal analgesia, and 86.4% expressed a need for further pain management education. The postgraduate training programme in Taiwan provides enhanced knowledge of opioids and improves physicians’ levels of confidence in acute and chronic pain management. However, only one-sixth of postgraduate physicians are aware that Taiwan does not have an opioid problem.
DOI: 10.6084/m9.figshare.28463563.v1
title: Knowledge, attitudes and practices of pain management among Taiwanese physicians in a reformed 2-year postgraduate training programme: a cross-sectional questionnaire survey

description: Taiwan implemented a reformed 6-year medical education in 2013, with a subsequent 2-year postgraduate training programme starting in August 2019. This study investigated the perceptions of acute and chronic pain management in postgraduate physicians. In late July 2023, a cross-sectional questionnaire survey was conducted of Taiwanese physicians who had almost completed their postgraduate 2-year or 1-year training and those who were starting a postgraduate programme in early August 2023. This survey evaluated their knowledge, attitude and clinical experience related to opioid-based pain management and their perceptions of the opioid crisis in the United States and Taiwan. Of the 197 postgraduate physicians, 169 (85.8%) responded to the survey. Physicians who had received postgraduate 2-year (<i>n</i> = 48) and 1-year (<i>n</i> = 51) training had a deeper understanding of opioids (<i>p</i> &lt; 0.001) and exhibited greater confidence in acute and chronic pain management (both <i>p</i> &lt; 0.001) compared with those who were just starting a postgraduate programme (<i>n</i> = 70). Of the included physicians, 92 (54.4%) were aware of the ongoing opioid crisis in the United States, but only 28 (16.6%) disagreed with the notion of a current opioid problem in Taiwan. Approximately 27.8% had never heard of multimodal analgesia, and 86.4% expressed a need for further pain management education. The postgraduate training programme in Taiwan provides enhanced knowledge of opioids and improves physicians’ levels of confidence in acute and chronic pain management. However, only one-sixth of postgraduate physicians are aware that Taiwan does not have an opioid problem.
DOI: 10.6084/m9.figshare.29315900
title: User experiences with a mobile health app for self-management of diabetes and hypertension in Ghana: a qualitative study

description: Cardio-metabolic disorders like diabetes and hypertension are increasingly common in low- and middle-income countries, including Ghana, straining healthcare systems. Mobile health (mHealth) applications offer potential for improving remote monitoring, patient engagement, and communication with providers. However, their implementation in Ghana remains limited and complex. This study explored user experiences with an mHealth app for self-managing diabetes and hypertension, and its perceived impact on care quality. A qualitative study was conducted with 20 participants from two healthcare facilities in Ghana using an mHealth app to manage diabetes or hypertension. In-depth interviews, guided by the Technology Acceptance Model (TAM), were audio-recorded, transcribed, and analyzed using thematic analysis. Participants reported that the app improved self-management, care coordination, and communication with providers. Valued features included medication reminders, appointment scheduling, and health monitoring, which fostered empowerment and engagement. The app also promoted healthier lifestyle choices. However, challenges such as data security concerns, mobile phone literacy, poor internet access, and data costs were noted. mHealth apps can enhance self-management and perceived care quality by supporting patient engagement and provider communication. To maximize their impact, challenges around digital literacy, connectivity, and data security must be addressed. Policymakers should promote secure, equitable, and sustainable integration of mHealth technologies into the healthcare system.
DOI: 10.6084/m9.figshare.29315900.v1
title: User experiences with a mobile health app for self-management of diabetes and hypertension in Ghana: a qualitative study

description: Cardio-metabolic disorders like diabetes and hypertension are increasingly common in low- and middle-income countries, including Ghana, straining healthcare systems. Mobile health (mHealth) applications offer potential for improving remote monitoring, patient engagement, and communication with providers. However, their implementation in Ghana remains limited and complex. This study explored user experiences with an mHealth app for self-managing diabetes and hypertension, and its perceived impact on care quality. A qualitative study was conducted with 20 participants from two healthcare facilities in Ghana using an mHealth app to manage diabetes or hypertension. In-depth interviews, guided by the Technology Acceptance Model (TAM), were audio-recorded, transcribed, and analyzed using thematic analysis. Participants reported that the app improved self-management, care coordination, and communication with providers. Valued features included medication reminders, appointment scheduling, and health monitoring, which fostered empowerment and engagement. The app also promoted healthier lifestyle choices. However, challenges such as data security concerns, mobile phone literacy, poor internet access, and data costs were noted. mHealth apps can enhance self-management and perceived care quality by supporting patient engagement and provider communication. To maximize their impact, challenges around digital literacy, connectivity, and data security must be addressed. Policymakers should promote secure, equitable, and sustainable integration of mHealth technologies into the healthcare system.
DOI: 10.6084/m9.figshare.30866612
title: Efficacy and safety of urate-lowering therapies in asymptomatic hyperuricaemia: a systematic review and network meta-analysis of key clinical outcomes

description: Asymptomatic hyperuricaemia (AH) is an independent risk factor for chronic kidney disease, cardiovascular events, and metabolic disorders. However, controversies persist regarding the clinical use of urate-lowering therapies (ULTs). This study employs a network meta-analysis (NMA) to systematically evaluate the efficacy and safety of ULTs in AH across seven key endpoints: serum uric acid (SUA), estimated glomerular filtration rate (eGFR), high-sensitivity C-reactive protein (hs-CRP), systolic blood pressure (SBP), major adverse cardiovascular events (MACE), composite renal events (CREs) and drug-induced liver injury (DILI). The findings aim to inform clinical decision-making. Four databases were systematically searched from their inception to March 2025 for all relevant literature, screening and evaluating randomized controlled trials (RCTs) assessing ULTs in AH. A frequentist NMA was conducted using R software. The Risk of Bias 2.0 tool was employed for bias assessment, and therapies were ranked <i>via</i> P-scores. In addition, transitivity assessment, network meta-regression, and sensitivity analysis were also performed. A total of 51 studies involving 8 ULTs and 10,281 subjects were included in this NMA. Random-effects modelling showed that, compared to controls, Verinurad_Febuxostat (P-score = 0.82; pooled mean difference [95% CI]: −3.20 [−4.76 to −1.64]) was the most effective in reducing SUA, Febuxostat (P-score = 0.78; 1.91 [0.47 to 3.35]) was the most effective in improving eGFR, Topiroxostat (P-score = 0.96; −6.10 [−11.75 to −0.45]) was most effective in improving SBP, and Febuxostat (P-score = 0.78; 0.77 [0.61 to 0.98]) reduced the risk of CREs most effectively. A None of the interventions showed significant differences in hs-CRP, MACE, or DILI. The Confidence in Network Meta-Analysis (CINeMA) assessment indicated that the overall quality of evidence was low to moderate. Available evidence suggests that febuxostat not only plays a significant role in lowering SUA levels but also significantly delays the decline in eGFR and reduces the risk of CREs.