cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.4225/03/5897b94b46600
title: Prehospital pain: epidemiology and management in Victoria, Australia

description: Pain is a commonly encountered condition in the prehospital and emergency medicine settings, and is associated with significant burden of disease.  This thesis explores the epidemiology of pain in the Victorian prehospital setting, and factors associated with the likelihood of clinically important pain severity reduction were identified from the interrogation of a large patient record database.  Seven factors were found to be associated with the likelihood of clinically important pain reduction following multivariate analyses.  These included: age, time criticality of the patient, pain aetiology, initial pain severity, analgesic agent or combination administered to the patient, scene time, and transport time.  

In 2007, ketamine was trialled in the prehospital setting as an analgesic agent.  In this prospective, randomised controlled trial, the administration of morphine followed by ketamine was found to be superior to morphine alone in the reduction of pain intensity in adult patients with moderate to severe pain following trauma in the prehospital setting.  Intravenous ketamine provided safe and effective analgesia to adult patients following injury. After accounting for differences between trial cluster sites, patients in the ketamine group had a mean verbal numerical rating scale (VNRS) pain reduction of 5.6 points compared with the M-group of 3.2 points (p&lt;0.0001).   

This study followed participants up to 12 months following enrolment into the ketamine study, identified those who continued to suffer from persistent pain, and assessed their health-related quality of life using the SF-36 questionnaire.  Statistically and clinically, there was no difference in the long term follow up between study groups with respect to the summary measures, subscale measures or global pain score. 

In light of the superiority of intravenous ketamine over morphine to reduce pain intensity in patients with moderate to severe traumatic injury, this agent warrants consideration by all emergency medical services (EMS) who have appropriate training and clinical governance.  Furthermore, ketamine was administered in a safe manner in this non-physician EMS setting.  It is likely that this work will result in Ambulance Victoria introducing ketamine as an alternative analgesic agent for the prehospital management of moderate to severe pain in trauma patients, and has the potential to influence change in EMS and emergency medicine practice nationally and internationally.  

In time, hopefully, these studies will make a major contribution to the early management of injured patients. Improved early management of pain and interventions aimed at other related factors could lead to more efficient rehabilitation, demonstrable decreases in morbidity, and improved quality of life.
DOI: 10.4225/03/5897b9eb015c5
title: Targeting the NO/sGC/cGMP signaling pathway in health and disease

description: The therapeutic utility of the nitric oxide (NO)/soluble guanylyl cyclase (sGC)/cyclic guanosine 3’5’-monophosphate (cGMP) pathway is well-recognised, with NO donors used in the treatment of diseases such as heart failure, acute hypertensive crisis and pulmonary hypertension. However, traditional nitrovasodilator therapy is somewhat limited due to the development of tolerance following prolonged administration. Furthermore, in vascular disease states such as hypertension, the NO/sGC/cGMP pathway appears to be dysfunctional. Such dysfunction is thought to arise as a consequence of oxidative stress and the associated increase in vascular superoxide anion radical (•O2-) levels, leading to enhanced scavenging of NO to form the oxidant, peroxynitrite (ONOO-). Indeed, ONOO- is able to oxidise the reduced (Fe2+) heme group of sGC, converting it into its NO-insensitive ferric (Fe3+) or heme-free forms. Under such conditions, the efficacy of NO donors/nitrovasodilators are compromised, due to their inability to target these altered states of sGC, underlining the need for novel non-NO based compounds. As such, this thesis examines the vaso-protective actions and therapeutic potential of the redox sibling of NO, nitroxyl (HNO), as well as NO-independent sGC stimulators (BAY 41-2272) and activators (BAY 58-2667) in a number of cardiovascular disease states.
From a clinical perspective, NO-independent compounds such as HNO donors and/or stimulators and activators of sGC may offer considerable therapeutic advantages over traditional nitrovasodilator therapies due to their well-documented resistance to •O2- scavenging and vascular tolerance development, as well as the ability to target oxidised/heme-free sGC (i.e. BAY 58-2667) and the potential to mediate their effects via cGMP-independent mechanisms of action. Such compounds may also offer the basis from which future therapies, for the treatment of cardiovascular diseases, are designed.
DOI: 10.5439/1342148
title: ARM: Ka-Band ARM Scanning Cloud Radar (KASACR) Filtered Spectral Data of Cross-Wind RHI Scan in Cross Mode

description: Ka-Band ARM Scanning Cloud Radar (KASACR) Filtered Spectral Data of Cross-Wind RHI Scan in Cross Mode
DOI: 10.5439/1342155
title: ARM: Ka-Band ARM Scanning Cloud Radar (KASACR) Filtered Spectral Data of Vertically Pointing Scan in Cross-Polarization Mode

description: Ka-Band ARM Scanning Cloud Radar (KASACR) Filtered Spectral Data of Vertically Pointing Scan in Cross-Polarization Mode
DOI: 10.5517/ccdc.csd.cc1mz9sp
title: CCDC 1518683: Experimental Crystal Structure Determination

description: Related Article: Iacopo Ciabatti, Cristina Femoni, Tiziana Funaioli, Maria Carmela Iapalucci, Stefano Merighi, Stefano Zacchini|2017|J.Organomet.Chem.|849-850|299|doi:10.1016/j.jorganchem.2017.01.029
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.14457/cmu.res.2003.371
title: ความสัมพันธ์ระหว่างราคากับคุณภาพของลำไยอบแห้ง /
DOI: 10.14457/cmu.res.2009.281
title: ความสัมพันธ์ระหว่างภาวะผู้นำกับความผูกพันต่อองค์การของหัวหน้างานมหาวิทยาลัยเชียงใหม่ /
DOI: 10.14457/cmu.res.2009.282
title: ความสัมพันธ์ระหว่างรูปแบบการจัดการความขัดแย้งของผู้บังคับบัญชา และความไว้วางใจต่อผู้บังคับบัญชากับความพึงพอใจต่อการบังคับบัญชา /
DOI: 10.14457/cmu.the.2008.759
title: ความสัมพันธ์ระหว่างมนุษย์กับธรรมชาติ ในทัศนะของกลุ่มเกษตรกรรมยั่งยืน /
DOI: 10.14457/nsru.the.2005.19
title: ยุทธศาสตร์การนิเทศภายในสถานศึกษาขั้นพื้นฐานสังกัดสำนักงานเขตพื้นที่การศึกษานครสวรรค์ เขต 2
DOI: 10.14457/nsru.the.2005.23
title: รูปแบบการพัฒนาพฤติกรรมเชิงจริยธรรมของนักเรียนโรงเรียนมัธยมศึกษา : กรณีศึกษาโรงเรียนชยานุกิจพิทยาคม จังหวัดชัยนาท
DOI: 10.15468/cw33jq
title: Species of Wadicosa (Araneae, Lycosidae): transfer of two species from Pardosa and description of three new species from Africa

description: This dataset contains the digitized treatments in Plazi based on the original journal article Torbjörn Kronestedt (2015): Species of Wadicosa (Araneae, Lycosidae): transfer of two species from Pardosa and description of three new species from Africa. European Journal of Taxonomy 132: 1-19, DOI: 10.5852/ejt.2015.132, URL: http://www.europeanjournaloftaxonomy.eu/index.php/ejt/article/view/254/0
DOI: 10.17632/ggds2grzw9.1
title: PHAST: Protein-like heteropolymer analysis by statistical thermodynamics

description: PHAST is a software package written in standard Fortran, with MPI and CUDA extensions, able to efficiently perform parallel multicanonical Monte Carlo simulations of single or multiple heteropolymeric chains, as coarse-grained models for proteins. The outcome data can be straightforwardly analyzed within its microcanonical Statistical Thermodynamics module, which allows for computing the entropy, caloric curve, specific heat and free energies. As a case study, we investigate the aggregation of heteropolymers bioinspired on Aβ25−33 fragments and their cross-seeding with IAPP20−29 isoforms. Excellent parallel scaling is observed, even under numerically difficult first-order like phase transitions, which are properly described by the built-in fully reconfigurable force fields. Still, the package is free and open source, this shall motivate users to readily adapt it to specific purposes.
DOI: 10.4225/03/5897b9fcec4e8
title: The lost comedian (a novel) & beyond the latticed view:  translating self, memory and place in a second language (exegesis)

description: The thesis consists of two parts, a creative component and an accompanying exegesis.
     My novel, The Lost Comedian, explores a young girl’s struggle to find her own moral compass through a religious crisis, her relationships with her peers and with adults in positions of power. It is mainly set in Sweden in the 1960s and 70s, but also moves back to the 1930s. By the time of her father’s death, the protagonist, Christina, is living a modest life in bay-side Melbourne. She returns to Sweden from Australia for her father’s funeral, and is confronted with her past and memories of growing up in the religious community of Svenstorp. The novel entwines two themes: 1) Christina’s development from a child with a strong sense of belonging and identity as a “Believer” to a teenage rebel, and the consequences of her rebellion; 2) Christina’s recovery from a secret, deeply personal loss that she has encountered in Melbourne, and the ever-present temptations of surrendering to a sense of guilt, punishment and self-destruction as a consequence of the “pagan” way of life to which she surrendered as a teenager in Sweden.  
     The exegesis, “Beyond the Latticed View: Translating Self, Memory and Place in a Second Language,” focuses on the linguistic and cultural translation processes when writing in a second language. Investigating gains and losses of this translation process, the exegesis explores the prospect of a “new” sense of self emerging in the “new” language. Specific Swedish social, literary and cultural influences that inform the novel are discussed in the context of its setting. The exegesis also examines the cultural translation processes that these influences instigate, and how writing from both a spatial and temporal distance when “translating” the past influences the novel. As well, practical translation issues when writing from an “other” culture and language are explored. While reflecting on the many challenges when writing in translation, the exegesis argues that translating “self, memory and place,” ultimately creates a richly rewarding narrative.
DOI: 10.5439/1342154
title: ARM: Ka-Band ARM Scanning Cloud Radar (KASACR) Filtered Spectral Data of Vertically Pointing High Resolution Scan in Cross-Polarization Mode

description: Ka-Band ARM Scanning Cloud Radar (KASACR) Filtered Spectral Data of Vertically Pointing High Resolution Scan in Cross-Polarization Mode
DOI: 10.6073/pasta/67577d05152dd1cd900e2e23fa252ab5
title: Dalton and Nenana study site data including: invasive plant density estimates, invasive plant density, soil data, seedling estimates for dominant tree species and ground cover estimates for sites.
DOI: 10.14457/kmitl.the.2002.411
title: การปรับปรุงสภาพทางกายภาพของชุมชน ในเขตพื้นที่ประวัติศาสตร์ กรณีศึกษา : การเปรียบเทียบความต้องการระหว่างนักท่องเที่ยวกับผู้อาศัยในชุมชนย่านบางลำพู, กรุงเทพมหานคร /
DOI: 10.14457/kmitl.the.2003.515
title: การพัฒนาเครื่องกวนน้ำดิน /
DOI: 10.14457/nsru.the.2004.12
title: การพัฒนาหลักสูตรกลุ่มสาระการเรียนรู้ภาษาไทย รายวิชาภาษาไทย 1 ชั้นมัธยมศึกษาปีที่ 1 สำหรับสถานศึกษาในเขตอำเภอเมือง จังหวัดนครสวรรค์
DOI: 10.14457/nsru.the.2004.13
title: ยุทธศาสตร์การบริหารงานการเงินของผู้บริหารโรงเรียนมัธยมศึกษาสังกัดกรมสามัญศึกษา จังหวัดชัยนาท
DOI: 10.14457/nsru.the.2005.24
title: รูปแบบการส่งเสริมธุรกิจประกันชีวิตในจังหวัดอุทัยธานี
DOI: 10.4225/03/5897b82dd892d
title: Studies of low oxidation state group 13 and 14 metallacycles

description: This thesis is mainly concerned with investigations into the reactivity of the gallium(I) N-heterocyclic carbene (NHC) analogue, [K(tmeda)][:Ga{[N(Dip)C(H)]2}] (Dip = C6H3Pri2-2,6).  The preparation of the first monomeric Ge(I) radical was also investigated.  Work carried out in these areas is divided into five chapters.  Chapter 1 provides a general introduction to sub-valent group 13 and 14 chemistry, with an emphasis on the preparation of group 13 metal(I) and group 14 metal(II) N-heterocyclic carbene analogues.  Chapter 2 summarizes investigations into the reactivity of [K(tmeda)] [:Ga{[N(Dip)C(H)]2}] towards groups 2 and 12 metal precursors.  Reactions of magnesium, calcium, strontium, barium, zinc, and cadmium halides with [K(tmeda)][:Ga{[N(Dip)C(H)]2}] are discussed, and the first structurally characterized cadmium-gallium bonded molecular complex is reported.  Chapter 3 summarizes investigations into the reactivity of [K(tmeda)] [:Ga{[N(Dip)C(H)]2}] towards selected lanthanide metal precursors.  Reactions of samarium(II), europium(II), ytterbium(II), thulium(II), and cerium(III) iodides with [K(tmeda)][:Ga{[N(Dip)C(H)]2}] have given rise to a number of novel lanthanide-gallyl species, including the first structurally characterized GaTm or GaSm bonded complexes.  Chapter 4 details the preparation of the first monomeric Ge(I) radical via the reduction of a bulky β-diketiminato germanium(II) precursor.  The verification of the +1 oxidation state in this species was achieved using a combination of crystallographic, EPR and ENDOR spectroscopic, and theoretical analyses. Chapter 5 describes several miscellaneous results, largely derived from attempts to prepare bulky guanidinato complexes of p-block elements in low oxidation states.
DOI: 10.4225/03/5897ba6fe2993
title: Monitoring respiratory function during neonatal resuscitation

description: The studies presented in this thesis show that a RFM can be used during mannequin based neonatal training program to: 1) teach correct mask hold and positioning techniques to diminish leak; 2) teach assessment of PIP and PEEP; 3) teach assessment of tidal volumes and adjustment of PIP to deliver an appropriate tidal volume. During neonatal resuscitation a RFM can provide continuous information about: 1) tidal volume 2) mask or ETT leak, 3) tube placement after endotracheal intubation, 5) the PIP and PEEP being delivered. In addition, I believe it provides valuable information about 1) ventilation rate, 2) inflation and expiration times, 3) the spontaneous breathing patterns, tidal volume and interaction with the inflations. Awards: Winner of the Mollie Holman Doctoral Medal for Excellence, Faculty of  Medicine, Nursing and Health Sciences, 2011.
DOI: 10.4225/03/5897baa111526
title: Inhibition of oxidative protein folding in gram-negative bacteria : fragment-based design of DsbA inhibitors.

description: The disulfide-dithioloxidoreductase enzyme DsbA is an oxidative folding catalyst found
in the bacterial periplasm and is a key determinant of virulence in Gram-negative
pathogens. DsbA has a wide spectrum of substrate specificity and has been demonstrated
to catalyse the formation of disulfides in numerous secreted proteins. DsbA operates at a
central point in the production of virulence-determinants because most virulence factors
are proteins that require disulfide bonds to be active. DsbA knockout mutants in E. coli,
have been shown to be impaired in a range of processes related to virulence.
Significantly, DsbA mutations in many pathogenic bacteria attenuate their virulence,
demonstrating the value of targeting DsbA to develop anti-bacterial agents to counteract
virulence. DsbA is a structurally as well as functionally well characterized protein which
has no direct homologue in eukaryotes. To date there are no known small molecule
inhibitors of this protein. Hence DsbA represents an attractive antibacterial target and is
the protein of interest for this project.
The current thesis reports the identification of scaffolds that are suitable starting points for
designing inhibitors of DsbA. These scaffolds were identified using a fragment-based
drug design (FBDD) approach. This study describes a structure assisted-FBDD process
performed to validate DsbA as an antibacterial drug target. A broad range of
complementary techniques were employed to identify inhibitors of DsbA from two
different Gram negative bacterial species; Escherichia coli and Vibrio cholerae. NMR
based screening of a fragment library was carried out in two rounds. Theprimary screen
employed STD (Saturation Transfer Difference) experiments to identify candidate hits and 1H-15N HSQC (Heteronuclear Single Quantum Coherence) experiments were used
to confirm binding. A number of strong hits were identified and the binding locations
were identified from the HSQC data. The binding efficiency of the fragments was
determined by calculating NMR-based dissociation constants.Several of these initial
binding fragments also show inhibitory activity in a phenotype assaysin E.coli. X-ray
crystallographic studies revealed that the most potent fragment hits bind in the
hydrophobic groove of EcDsbA in adjacent or overlapping positions.
Charactisation of the structures of complexes of EcDsbA with theoriginal NMR hits was
followed by fragment elaboration through structure-guided medicinal chemistry efforts.
Preliminary structure-activity relationships(SAR) were identified for several series. This
SAR will facilitate the development of novel DsbA inhibitors that specifically target
functionally important protein surface sites.
In conclusion, this study presentsthe discovery of novel small molecule inhibitors of
DsbA and provides insights into the development of potential DsbA inhibitors as
antibacterial drug candidates.
DOI: 10.5439/1342152
title: ARM: Ka-Band ARM Scanning Cloud Radar (KASACR) Filtered Spectral Data of Vertically Pointing High Resolution Scan in Co-Polarization Mode

description: Ka-Band ARM Scanning Cloud Radar (KASACR) Filtered Spectral Data of Vertically Pointing High Resolution Scan in Co-Polarization Mode
DOI: 10.5517/ccdc.csd.cc1n08qn
title: CCDC 1519611: Experimental Crystal Structure Determination

description: Related Article: Marcus Baumann, Ian R. Baxendale|2017|Bioorg.Med.Chem.|25|6218|doi:10.1016/j.bmc.2017.01.022
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.6073/pasta/fa892171773e6ffdd4d125aaa7c4b794
title: Final seedling counts for invasive plants seeded at CPCRW on a variety of substrate types.
DOI: 10.14457/cmu.res.2007.218
title: ความสัมพันธ์ระหว่างระดับคอนโดรอิตินซิกซัลเฟตและแอลคาไลน์ฟอสฟาเตสในของเหลวร่องเหงือกมนุษย์ และสภาวะโรคปริทันต์อักเสบเรื้อรัง /
DOI: 10.14457/cmu.res.2008.339
title: ความสัมพันธ์ระหว่างระดับความสามารถ ในการจัดการทางการเงิน และระดับความสำเร็จ ในการประกอบธุรกิจของผู้รับเหมาก่อสร้าง ในจังหวัดเชียงใหม่ /
DOI: 10.14457/kmitl.the.2003.514
title: การออกแบบวงจรซีมอสคูณสัญญาณกระแสกับแรงดันแบบอนาลอก 4 ควอดแรนท์ /
DOI: 10.4231/r7td9v91
title: Supporting data for Ma and Weake 2014 JoVE publication

description: Supporting and raw data for Figures 1, 2, 3 and Table 1 from: Ma, J. and Weake, V.M. (2014). Affinity-based isolation of tagged nuclei from Drosophila tissues for gene expression analysis. Journal of Visualized Experiments 85. PMID:24686501.
DOI: 10.5517/ccdc.csd.cc1mz9tq
title: CCDC 1518684: Experimental Crystal Structure Determination

description: Related Article: Iacopo Ciabatti, Cristina Femoni, Tiziana Funaioli, Maria Carmela Iapalucci, Stefano Merighi, Stefano Zacchini|2017|J.Organomet.Chem.|849-850|299|doi:10.1016/j.jorganchem.2017.01.029
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc1mz9vr
title: CCDC 1518685: Experimental Crystal Structure Determination

description: Related Article: Iacopo Ciabatti, Cristina Femoni, Tiziana Funaioli, Maria Carmela Iapalucci, Stefano Merighi, Stefano Zacchini|2017|J.Organomet.Chem.|849-850|299|doi:10.1016/j.jorganchem.2017.01.029
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc1mz9xt
title: CCDC 1518687: Experimental Crystal Structure Determination

description: Related Article: Iacopo Ciabatti, Cristina Femoni, Tiziana Funaioli, Maria Carmela Iapalucci, Stefano Merighi, Stefano Zacchini|2017|J.Organomet.Chem.|849-850|299|doi:10.1016/j.jorganchem.2017.01.029
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc1mz9yv
title: CCDC 1518688: Experimental Crystal Structure Determination

description: Related Article: Iacopo Ciabatti, Cristina Femoni, Tiziana Funaioli, Maria Carmela Iapalucci, Stefano Merighi, Stefano Zacchini|2017|J.Organomet.Chem.|849-850|299|doi:10.1016/j.jorganchem.2017.01.029
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.14457/kmitl.the.2001.10
title: การหาประสิทธิภาพบทเรียนโมดูล เรื่อง ลอจิกเกทพื้นฐาน /
DOI: 10.14457/kmitl.the.2002.412
title: การผสมภาพทางการแพทย์ โดยใช้การแปลงเวฟเลท /
DOI: 10.14457/nsru.the.2003.13
title: การเปรียบเทียบความเข้าใจในการอ่านภาษาอังกฤษของนักเรียนชั้นประถมศึกษาปีที่ 6 ที่ได้รับการสอนวิจัยวิธีสอนเอ อาร์ ซี และวิธีสอนตามคู่มือครู
DOI: 10.5517/ccdc.csd.cc1n08rp
title: CCDC 1519612: Experimental Crystal Structure Determination

description: Related Article: Marcus Baumann, Ian R. Baxendale|2017|Bioorg.Med.Chem.|25|6218|doi:10.1016/j.bmc.2017.01.022
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc1n0wxg
title: CCDC 1520206: Experimental Crystal Structure Determination

description: Related Article: Chelladurai Ganesamoorthy, Christoph Wölper, Libor Dostál, Stephan Schulz|2017|J.Organomet.Chem.|845|38|doi:10.1016/j.jorganchem.2017.01.007
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.