cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.5281/zenodo.18352196
title: Next-Generation Gene Editing: A Conceptual Framework for Precision Genomic Engineering Beyond CRISPR-Cas Systems

description: CRISPR-Cas systems have revolutionized genetic engineering by facilitating targeted genomic modifications. However, persistent limitations include off-target effects, protospacer adjacent motif (PAM) sequence dependency, delivery inefficiencies, and immunogenicity. This paper proposes a conceptual framework for a next-generation gene editing platform, the Adaptive Nuclease-Free Programmable Editor (ANFPE). ANFPE integrates computational design of biomolecular components, targeted epigenetic modifications, and AI-optimized nanomaterial delivery systems to mitigate these limitations. It employs a nuclease-independent mechanism utilizing sequence-specific molecular recognition and chromatin remodeling, directed by machine learning algorithms. The framework delineates theoretical underpinnings, engineering methodologies, computational simulations including detailed Sobol sensitivity and uncertainty analyses, and a developmental roadmap aimed at attaining superior precision, efficacy, and safety relative to CRISPR-based approaches. A case study on the HBB gene locus for sickle cell disease validates the model using real-world kinetic and chromatin data from published literature and ENCODE datasets, bridging computational predictions to biological realism.
DOI: 10.5281/zenodo.18352197
title: Next-Generation Gene Editing: A Conceptual Framework for Precision Genomic Engineering Beyond CRISPR-Cas Systems

description: CRISPR-Cas systems have revolutionized genetic engineering by facilitating targeted genomic modifications. However, persistent limitations include off-target effects, protospacer adjacent motif (PAM) sequence dependency, delivery inefficiencies, and immunogenicity. This paper proposes a conceptual framework for a next-generation gene editing platform, the Adaptive Nuclease-Free Programmable Editor (ANFPE). ANFPE integrates computational design of biomolecular components, targeted epigenetic modifications, and AI-optimized nanomaterial delivery systems to mitigate these limitations. It employs a nuclease-independent mechanism utilizing sequence-specific molecular recognition and chromatin remodeling, directed by machine learning algorithms. The framework delineates theoretical underpinnings, engineering methodologies, computational simulations including detailed Sobol sensitivity and uncertainty analyses, and a developmental roadmap aimed at attaining superior precision, efficacy, and safety relative to CRISPR-based approaches. A case study on the HBB gene locus for sickle cell disease validates the model using real-world kinetic and chromatin data from published literature and ENCODE datasets, bridging computational predictions to biological realism.
DOI: 10.3535/44t-we0-zz1
title: Palaemon Weber, 1795

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/am2-j1e-08z
title: Microprosthema inornatum Manning & Chace, 1990

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.15468/dl.z3g8tb
title: Occurrence Download

description: A dataset containing 5 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Hyla barbudensis"
 ]
}

 The dataset includes 5 records from 2 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0007497-260120142942310/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.vvyqcp
title: Occurrence Download

description: A dataset containing 172 species occurrences available in GBIF matching the query:
{
 "and" : [
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 "TaxonKey is Betula dahurica",
 "Year 1970-2000"
 ]
}

 The dataset includes 172 records from 8 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0007496-260120142942310/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.5258/soton/d3686
title: Dataset in support of the paper 'High-efficiency Mid-infrared Wavelength Conversion in Silicon Waveguides'

description: This dataset contains:
The raw data of FIG.1c is 'fig1c.xlsx'.
 The raw data of FIG.3a is 'fig3a.xlsx'.
The raw data of FIG.3b is 'fig3b.xlsx'.
The raw data of FIG.4a is 'fig4a.csv'.
The raw data of FIG.4b is 'fig4b.xlsx'.


Paper has been accepted by APL Photonics
DOI: 10.21227/8666-tw11
title: "ComFASE Data Log Associated with the Article: Start-Time Sensitivity of Barrage Jamming on Connected Automated Vehicles in Dynamic Scenarios"

description: "The ComFASE Attack Injection Campaign Log.csv dataset supports the experimental evaluation presented in the paper \u201cStart-Time Sensitivity of Barrage Jamming on Connected Automated Vehicles in Dynamic Scenarios.\u201d The dataset contains detailed logs from a large-scale attack-injection campaign used to analyze how the timing of barrage jamming attacks, specifically, attack initiation, affects the safety and behavior of connected automated vehicle platoons. Using this data, the paper evaluates the impact of jamming on collision occurrence, severe outcomes, and vehicle-level dynamics across distinct acceleration and deceleration phases of a driving scenario. The dataset enables systematic analysis of communication degradation, attack duration, and value, and their relationship to system vulnerability, thereby supporting reproducibility and further research on communication resilience and cybersecurity in cooperative driving systems."
DOI: 10.5281/zenodo.18352198
title: EKOLOGIK NOQULAY HUDUDDA YASHOVCHI BOLALARDA NAFAS YO'LLARI KASALLIKLARINING ERTA SHAKLLANISH MEXANIZMLARI VA OLDINI OLISH STRATEGIYALARI

description: Mazkur ilmiy maqolada ekologik jihatdan noqulay hududlarda yashovchi bolalarda nafas yo‘llari kasalliklarining erta rivojlanish mexanizmlari hamda ularning oldini olishga qaratilgan zamonaviy strategiyalar tahlil qilinadi. Atmosfera havosining ifloslanishi, sanoat chiqindilari, chang zarralari, og‘ir metallar va allergenlarning bolalar organizmiga ta’siri ilmiy manbalar asosida yoritiladi. Shuningdek, bolalarda immun tizimning yetilmaganligi tufayli respirator kasalliklarga yuqori sezuvchanlik sabablari ochib beriladi. Profilaktik chora-tadbirlar, jumladan, ekologik monitoring, tibbiy nazorat va sog‘lom turmush tarzini shakllantirish masalalari asoslab beriladi.
DOI: 10.5281/zenodo.18352199
title: EKOLOGIK NOQULAY HUDUDDA YASHOVCHI BOLALARDA NAFAS YO'LLARI KASALLIKLARINING ERTA SHAKLLANISH MEXANIZMLARI VA OLDINI OLISH STRATEGIYALARI

description: Mazkur ilmiy maqolada ekologik jihatdan noqulay hududlarda yashovchi bolalarda nafas yo‘llari kasalliklarining erta rivojlanish mexanizmlari hamda ularning oldini olishga qaratilgan zamonaviy strategiyalar tahlil qilinadi. Atmosfera havosining ifloslanishi, sanoat chiqindilari, chang zarralari, og‘ir metallar va allergenlarning bolalar organizmiga ta’siri ilmiy manbalar asosida yoritiladi. Shuningdek, bolalarda immun tizimning yetilmaganligi tufayli respirator kasalliklarga yuqori sezuvchanlik sabablari ochib beriladi. Profilaktik chora-tadbirlar, jumladan, ekologik monitoring, tibbiy nazorat va sog‘lom turmush tarzini shakllantirish masalalari asoslab beriladi.
DOI: 10.6084/m9.figshare.31136554
title: OCT images for Papilledema Detection and Grading

description: The data repository is organized into three main folders: Papilledema, Pseudo papilledema, and Normal, for the detection phase. For the grading phase, the Papilledema folder is further divided into four subfolders, labeled G1 to G4, corresponding to different severity levels.
DOI: 10.6084/m9.figshare.31136554.v1
title: OCT images for Papilledema Detection and Grading

description: The data repository is organized into three main folders: Papilledema, Pseudo papilledema, and Normal, for the detection phase. For the grading phase, the Papilledema folder is further divided into four subfolders, labeled G1 to G4, corresponding to different severity levels.
DOI: 10.15468/dl.cp9su5
title: Occurrence Download

description: A dataset containing 4478 species occurrences available in GBIF matching the query:
{
 "and" : [
 "BasisOfRecord is Specimen",
 "Country is one of (Mexico, United States of America, Colombia, Ecuador, Paraguay, Nicaragua, Dominican Republic, Venezuela (Bolivarian Republic of), Brazil, Peru)",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "TaxonKey is Tillandsia recurvata"
 ]
}

 The dataset includes 4478 records from 292 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0007495-260120142942310/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.6084/m9.figshare.31129045
title: ProteomeScout_Dataset

description: ProteomeScout data that integrates protein and PTM-level information from various databases, including UniProt, PhosphoSitePlus, HPRD, and PhosphoELM. Directly works with ProteomeScoutAPI to peruse the data and extract information, such as for annotating phosphoproteomic datasets: NaegleLab/ProteomeScoutAPI.While the data has been updated since the original publication, see the original Proteome Scout publication for more details on what this data entails: ProteomeScout: a repository and analysis resource for post-translational modifications and proteins | Nucleic Acids Research | Oxford Academic
DOI: 10.6084/m9.figshare.31129045.v1
title: ProteomeScout_Dataset

description: ProteomeScout data that integrates protein and PTM-level information from various databases, including UniProt, PhosphoSitePlus, HPRD, and PhosphoELM. Directly works with ProteomeScoutAPI to peruse the data and extract information, such as for annotating phosphoproteomic datasets: NaegleLab/ProteomeScoutAPI.While the data has been updated since the original publication, see the original Proteome Scout publication for more details on what this data entails: ProteomeScout: a repository and analysis resource for post-translational modifications and proteins | Nucleic Acids Research | Oxford Academic
DOI: 10.5281/zenodo.18352100
title: ON ADAPTIVE CONTROL OF ELECTRIC VEHICLES CONSIDERING OPERATING CONDITIONS

description: Electriccarsdriveinalotofdifferentconditions,whichchangehowtheyworkandhowmuchenergytheyuseallthetime.Theslopeoftheroad,theweightofthevehicle,thestateofchargeofthebattery,andthedriver'sdemandalladduncertaintythatmakestraditionalfixed-parametercontrolstrategieslesseffective.Thesekindsofcontrollersmightworkwellinnormalsituations,buttheyoftendon'tworkaswellinreallife.Thismakesbatteriesworkharderandusesmoreenergy.Thispaperpresentsanadaptivecontrolframeworkforelectricvehiclesthatexplicitlyaddressesvaryingoperationalconditions.Acontrol-orientedmodeloftheelectricvehicleisdeveloped,incorporatingtheessentialinteractionsbetweenlongitudinalvehicledynamics,theelectricdrivetrain,andthebatteryenergysystem.Thisformulationpositsthatthecontrolproblemischaracterizedbyparametersthatareoftenuncertainandsubjecttotemporalvariation,inadditiontopracticalconstraintsonmotortorqueandbatteryoperationallimits.Theproposedmethodincorporatesknowledgeofoperatingconditionsdirectlyintothecontrolstrategy,enablingreal-timeadjustmentsofcontrolparametersinresponsetovariationsinroadconditions,vehiclemass,andbatterystatus.Thefunctionofthecontrolleristrackvehiclespeedandmakeitmoreenergy-efficientwhilealsolimitinghowmuchpowerthebatteryneeds.Itdoesthisbychanginghowmuchtorquethetractionmotorhas.Theformulaalsomakessurethatitworkswiththelimitsofregenerativebraking,whichmakesitsafeandeasytouse
DOI: 10.5281/zenodo.18352099
title: ON ADAPTIVE CONTROL OF ELECTRIC VEHICLES CONSIDERING OPERATING CONDITIONS

description: Electriccarsdriveinalotofdifferentconditions,whichchangehowtheyworkandhowmuchenergytheyuseallthetime.Theslopeoftheroad,theweightofthevehicle,thestateofchargeofthebattery,andthedriver'sdemandalladduncertaintythatmakestraditionalfixed-parametercontrolstrategieslesseffective.Thesekindsofcontrollersmightworkwellinnormalsituations,buttheyoftendon'tworkaswellinreallife.Thismakesbatteriesworkharderandusesmoreenergy.Thispaperpresentsanadaptivecontrolframeworkforelectricvehiclesthatexplicitlyaddressesvaryingoperationalconditions.Acontrol-orientedmodeloftheelectricvehicleisdeveloped,incorporatingtheessentialinteractionsbetweenlongitudinalvehicledynamics,theelectricdrivetrain,andthebatteryenergysystem.Thisformulationpositsthatthecontrolproblemischaracterizedbyparametersthatareoftenuncertainandsubjecttotemporalvariation,inadditiontopracticalconstraintsonmotortorqueandbatteryoperationallimits.Theproposedmethodincorporatesknowledgeofoperatingconditionsdirectlyintothecontrolstrategy,enablingreal-timeadjustmentsofcontrolparametersinresponsetovariationsinroadconditions,vehiclemass,andbatterystatus.Thefunctionofthecontrolleristrackvehiclespeedandmakeitmoreenergy-efficientwhilealsolimitinghowmuchpowerthebatteryneeds.Itdoesthisbychanginghowmuchtorquethetractionmotorhas.Theformulaalsomakessurethatitworkswiththelimitsofregenerativebraking,whichmakesitsafeandeasytouse
DOI: 10.15468/dl.28wwje
title: Occurrence Download

description: A dataset containing 621 species occurrences available in GBIF matching the query:
{
 "and" : [
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 "TaxonKey is Populus suaveolens",
 "Year 1970-2000"
 ]
}

 The dataset includes 621 records from 46 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0007499-260120142942310/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.hpsh55
title: Occurrence Download

description: A dataset containing 6377 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Krefftichthys anderssoni",
 "HasCoordinate is true",
 "DecimalLatitude is greater than -90",
 "DecimalLatitude is less than 10",
 "DecimalLongitude is greater than -180",
 "OccurrenceStatus is Present",
 "Year is greater than or equal to 1950",
 "Year is less than or equal to 2014"
 ]
}

 The dataset includes 6377 records from 32 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0007500-260120142942310/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.nagt8j
title: Occurrence Download

description: A dataset containing 36706 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is Portugal",
 "TaxonKey is Gyps fulvus"
 ]
}

 The dataset includes 36706 records from 37 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0007501-260120142942310/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.x84v9h
title: Occurrence Download

description: A dataset containing 70 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Alepidea amatymbica",
 "HasCoordinate is true",
 "BasisOfRecord is one of (Specimen)"
 ]
}

 The dataset includes 70 records from 5 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0007502-260120142942310/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.3535/v1w-ja9-n75
title: Cyamus boopis Lütken, 1870

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/gxq-r32-6sm
title: Penaeus notialis Pérez Farfante, 1967

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/bfd-858-6q5
title: Hippolyte Leach, 1814

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/zz2-kbs-lkf
title: Latreutes parvulus (Stimpson, 1871)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.15468/dl.3r754e
title: Occurrence Download

description: A dataset containing 2 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is China",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 "TaxonKey is Brachiaria mutica (Forssk.) Stapf"
 ]
}

 The dataset includes 2 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0009652-250515123054153/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.epfxwd
title: Occurrence Download

description: A dataset listing the 1 species recorded in GBIF matching the query:
{
 "and" : [
 "DatasetKey is Cornell University Insect Collection (CUIC)",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 "TaxonKey is Andrena wilkella (Kirby, 1802)"
 ]
}

 The dataset's 1 records were derived from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0009647-250515123054153/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.cxd4ve
title: Occurrence Download

description: A dataset containing 251400 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Psyllaephagus faustus Riek, 1962, Cirrospilus margiscutellum (Girault, 1939), Chrysonotomyia chamaeleon (Girault, 1922), Anastatus japonicus Ashmead, 1904, Megastigmus transvaalensis (Hussey, 1956), Psyllaephagus bliteus Riek, 1962, Teratosphaeria gauchensis (M.-N.Cortinas, Crous & M.J.Wingf.) M.J.Wingf. & Crous, Teratosphaeria zuluensis (M.J.Wingf., Crous & T.A.Cout.) M.J.Wingf. & Crous, Temognatha flavocincta (Gory & Laporte, 1838), Melobasis sexplagiata (Laporte & Gory, 1837), Phyllolyma fracticosta (Walker, 1858), Pseudotargionia comata (Maskell, 1896), Platyobria lewisi Taylor, 1987, Thaumastocoris australicus Kirkaldy, 1908, Pseudotargionia asymmetrica Brimblecombe, 1959, Phyllolyma rufa (Froggatt, 1900), Eurymeloides pulchra (Signoret, 1850), Glycaspis eremica Moore, 1970, Creiis corniculatus (Froggatt, 1900), Glycaspis fuscovena Moore, 1970, Glycaspis amnicola Moore, 1961, Crompus opacus Scudder, 1958, Glycaspis blakei Moore, 1970, Anoeconeossa bundoorensis Taylor & Burckhardt, 2013, Selitrichodes kryceri Kim & La Salle, 1913, Amorbus biguttatus Stål, 1873, Creiis costatus (Froggatt, 1923), Hyalinaspis semispherula Taylor, 1962, Cardiaspina albitextura Taylor, 1962, Theseus modestus, Hyalinaspis rubra (Froggatt, 1903), Quadrastichus mendeli Kim & La Salle, Blastopsylla occidentalis Taylor, 1985, Thaumastocoris peregrinus D.L.Carpintero & Dellapé, 2006, Fergusobia camaldulensae Davies, Giblin Davis, Ye, Taylor & Thomas, 2012, Phascolarctos cinereus (Goldfuss, 1817), Phylacteophaga froggatti Riek, 1955, Gonipterus platensis (Marelli, 1926), Psyllaephagus pilosus Noyes, 1988, Glycaspis minuscula Moore, 1961, Ctenarytaina eucalypti (Maskell, 1890), Australopsylla revoluta (Froggatt, 1900), Blastopsylla octosetulae Taylor, 1985, Apleurotropis unnotipennis (Girault, 1915), Anoeconeossa vespertina Taylor, 1987, Glycaspis subita Moore, 1970, Anilara nigrita Kerremans, 1898, Anilara antiqua Théry, 1911, Neoleonardia chitinosa Brimblecombe, 1953, Biromiris scheyville Menard & Schuh, 2011)",
 "HasCoordinate is true",
 "HasGeospatialIssue is false"
 ]
}

 The dataset includes 251400 records from 120 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0009642-250515123054153/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.xu9bhh
title: Occurrence Download

description: A dataset containing 126664 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Morus capensis (Lichtenstein, 1823)",
 "HasCoordinate is true"
 ]
}

 The dataset includes 126664 records from 30 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0009938-250525065834625/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.4xea53
title: Occurrence Download

description: A dataset containing 232 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Continent is South America",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 "TaxonKey is Giardia Künstler, 1882",
 "Year 2000-2025"
 ]
}

 The dataset includes 232 records from 4 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0016131-250525065834625/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.7280/d14t2k
title: The direct and indirect effects of environmental toxicants on the health of bumble bees and their microbiomes

description: Bumble bees (Bombus spp.) are important and widespread insect pollinators,
 but the act of foraging on flowers can expose them to harmful pesticides
 and chemicals such as oxidizers and heavy metals. How these compounds
 directly influence bee survival and indirectly affect bee health via the
 gut microbiome is largely unknown. As toxicants in floral nectar and
 pollen take many forms, we explored the genomes of bee-associated microbes
 for their potential to detoxify cadmium, copper, selenate, the
 neonicotinoid pesticide imidacloprid, and hydrogen peroxide - which have
 all been identified in floral nectar and pollen. We then exposed Bombus
 impatiens workers to varying concentrations of these chemicals via their
 diet and assayed direct effects on bee survival. Using field-realistic
 doses, we further explored indirect effects on bee microbiomes. We found
 multiple putative genes in core gut microbes that may aid in detoxifying
 harmful chemicals. We also found that while the chemicals are largely
 toxic at levels within and above field-realistic concentrations, the
 field-realistic concentrations - except for imidacloprid - altered the
 composition of the bee microbiome, potentially causing gut dysbiosis.
 Overall, our study shows that chemicals found in floral nectar and pollen
 can cause bee mortality, and likely have indirect, deleterious effects on
 bee health via their influence on the bee microbiome.