cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.5281/zenodo.10020760
title: Public data for nonlinear optical computational histology

description: Experimental datasets for training and testing nonlinear optical computational histology (NOCH), which include label-free nonlinear optical data: stimulated Raman scattering (SRS) images of human brain tumors and multiphoton (MP) images of human ovarian cancers, and the corresponding H&E slices. The contrastive deep learning framework can generate diagnostic quality H&E slides comparable to conventional histopathology.  

If you find this work useful in your research, please consider citing the paper:

B. Shen, Z. Li, Y. Pan, Y. Guo, Z. Yin, R. Hu, J. Qu, L. Liu, Noninvasive Nonlinear Optical Computational Histology. Adv. Sci. 2023, 2308630.
DOI: 10.6084/m9.figshare.24971892
title: Supplementary Material for: The association of glaucoma with ischemic stroke and functional outcome after ischemic stroke from the perspective of causality

description: Introduction: Glaucoma may be related to ischemic stroke (IS) and poor outcomes after IS in observational studies, while the causal association remains unclear.
Methods: We obtained single nucleotide polymorphisms (SNPs) related to glaucoma from the gene-wide association study (GWAS) conducted by the FinnGen consortium. The GWAS included a total of 13,614 cases and 295,540 controls. The summary-level of datasets regarding IS were collected from the MEGASTROKE consortium, including 34,217 cases and 406,111 controls. Furthermore, we acquired summary statistics datasets for functional outcomes following IS from the GWAS meta-analysis conducted by the GISCOME consortium, which involved 6,021 individuals. The genetic association estimates for functional outcomes at 90 days after IS were evaluated by the modified Rankin Score (mRS), including 3,741 cases with good functional outcomes (mRS=0-2) and 2,280 subjects with poor functional outcomes post-stroke (mRS=3-6). Inverse variance weighting (IVW) was used as the primary method, complemented by sensitivity analyses for pleiotropy and increasing robustness.
Results: Genetically, glaucoma is associated with an increased risk of IS (odds ratio [OR]=1.08, 95% confidence interval [CI] = 1.02-1.14, P = 0.0039), as well as poor prognosis after IS with adjustment for severity (OR=1.64; 95% CI=1.27-2.13, P=0.0001) and functional outcome after IS (OR=1.45, 95% CI=1.12-1.87, P=0.0038). Through sensitivity analyses, we confirmed the robustness of the results. In addition, we did not identify any causal association between IS, functional outcome after IS, and glaucoma in reverse analysis.
Conclusion: Our study provides evidence suggesting a potential genetic causal relationship between glaucoma and an increased risk of IS, as well as a poor functional outcome following IS. Future studies are necessary to confirm these findings.
DOI: 10.6084/m9.figshare.24792567.v1
title: Ecological genetics of isolated loach populations

description: Many endangered species live in fragmented and isolated populations with low genetic variability, signs of inbreeding, and small effective population sizes - all features elevating their extinction risk. The flat-headed loach (<i>Oreonectes platycephalus</i>), a small noemacheilid fish, is found widely across southern China, but only in headwaters of hillstreams; as a result, they are spatially isolated from conspecific populations. We surveyed single nucleotide polymorphisms in 16 Hong Kong populations of <i>O. platycephalus</i> to determine whether loach populations from different streams were genetically isolated from each other, showed low levels of genetic diversity and signs of inbreeding, and had small effective population sizes. Estimates of average observed heterozygosity (<i>H</i><sub><em>O</em></sub> = 0.0473), nucleotide diversity (<i>π</i> = 0.0558) and effective population sizes (<i>N</i><sub><em>e</em></sub> = 14.1 - 198.2) were very low, and several populations showed clear signs of inbreeding as judged from relatedness estimates. The degree of genetic differentiation among populations was very high (average <i>F</i><sub><em>ST</em></sub> = 0.668), even over short geographic distances (&lt; 1.5 km), with strong patterns of isolation by distance. These results suggest that Hong Kong populations of <i>O. platycephalus</i> have experienced genetic drift and loss of genetic variability because sea-level rise after the last glaciation reduced connectedness among paleodrainages, isolating populations in headwaters. All this, together with the fact that the levels of genetic diversity and <i>N</i><sub><em>e</em></sub>s within local loach populations are lower than most other freshwater fishes, suggests that they face high extinction risk and limited capacity for future adaptation.
DOI: 10.57745/xescwc
title: README.txt

description: :unav
DOI: 10.57745/oimod7
title: 2023-12-22_Dataset_KXRProductionCrossSection_Gold.tab

description: :unav
DOI: 10.57745/wsbbe5
title: 2023-12-22_Dataset_KXRProductionCrossSection_Copper.tab

description: :unav
DOI: 10.57745/maundy
title: 2023-12-22_Dataset_KXRProductionCrossSection_Chromium.tab

description: :unav
DOI: 10.57745/oeg8ov
title: 2023-12-22_Dataset_KXRProductionCrossSection_Molybdenum.tab

description: :unav
DOI: 10.57745/34zhit
title: 2023-12-22_Dataset_KXRProductionCrossSection_Silver.tab

description: :unav
DOI: 10.57745/xwyohz
title: 2023-12-22_Dataset_KXRProductionCrossSection_Titanium.tab

description: :unav
DOI: 10.6084/m9.figshare.21350971
title: Logistic regression analysis to determine gender specific challenges and factors affecting seaweed farming along the coast of Tanzania mainland

description: Seaweed farming started 1989 in Zanzibar as a commercial enterprise when private entrepreneurs established experimental farms on the east coast in Paje and Jambiani villages, after significant substantial research on the possibilities of farming seaweed in 1970s. Then it was expanded to mainland Tanzania in the 1990s. Despite various interventions implemented over 30 years to improve coastal community’s livelihood through seaweed farming; the socioeconomic development of the coastal communities is not comparable to efforts invested to promote seaweed farming. Seven districts were surveyed. Data collection involved questionnaires administered to 208 random sampled farmers; and purposive sampling for focus group discussions and key informant interviews. Snowball technique was used in villages with few farmers. Findings unveiled significant challenges influences farmers’ choice to quit or continue with seaweed farming. Challenges specific to female gender e.g., lack of transportation facilities, theft, and inadequate funding were identified; and recommendations are provided for successful seaweed farming in Tanzania.
DOI: 10.6084/m9.figshare.21350971.v1
title: Logistic regression analysis to determine gender specific challenges and factors affecting seaweed farming along the coast of Tanzania mainland

description: Seaweed farming started 1989 in Zanzibar as a commercial enterprise when private entrepreneurs established experimental farms on the east coast in Paje and Jambiani villages, after significant substantial research on the possibilities of farming seaweed in 1970s. Then it was expanded to mainland Tanzania in the 1990s. Despite various interventions implemented over 30 years to improve coastal community’s livelihood through seaweed farming; the socioeconomic development of the coastal communities is not comparable to efforts invested to promote seaweed farming. Seven districts were surveyed. Data collection involved questionnaires administered to 208 random sampled farmers; and purposive sampling for focus group discussions and key informant interviews. Snowball technique was used in villages with few farmers. Findings unveiled significant challenges influences farmers’ choice to quit or continue with seaweed farming. Challenges specific to female gender e.g., lack of transportation facilities, theft, and inadequate funding were identified; and recommendations are provided for successful seaweed farming in Tanzania.
DOI: 10.5281/zenodo.10449061
title: Different Formation Modes of the North‒South-Trending Rifts in Southern Tibet: Implications from Ambient Noise Tomography

description: This dataset consists of two parts. The CFs_STB_2022_2023_1_80s.zip contains correlation functions of the station pairs, and disps_STB_2022_2023.zip contains the Rayleigh surface wave phase velocity dispersion curves.
DOI: 10.5281/zenodo.10449062
title: Different Formation Modes of the North‒South-Trending Rifts in Southern Tibet: Implications from Ambient Noise Tomography

description: This dataset consists of two parts. The CFs_STB_2022_2023_1_80s.zip contains correlation functions of the station pairs, and disps_STB_2022_2023.zip contains the Rayleigh surface wave phase velocity dispersion curves.
DOI: 10.6084/m9.figshare.24971919
title: Interactome data

description: Interactome data
DOI: 10.6084/m9.figshare.24971919.v1
title: Interactome data

description: Interactome data
DOI: 10.6084/m9.figshare.24971907
title: Proteomics data

description: Proteomics data
DOI: 10.5281/zenodo.10477327
title: Formulation and In-Vitro Evaluation of Gastroretensive Drug Delivery System of Ritonavir

description: The purpose of the research work was to develop a floating drug delivery system of Ritonavir in order to prolong the gastric residence time and increase its bioavailability. Gastroretensive retentive drug delivery system is designed with the aim to target the drug to its absorption site and to maintain the dosage form at that site for an extended period of time. To develop a floating Mucoadhesive tablet of ritonavir to prolong the gastric retention time for effective drug delivery system. Floating Mucoadhesive tablet of ritonavir was prepared successfully by direct compression method. Compatibility study of ritonavir with formulation ingredients was performed by DSC and FTIR results revealed that drug was compatible with all selected excipients. The present investigation was aimed to formulate floating drug delivery system using effervescent agent sodium bicarbonate and citric acid the tablet continuously floats for more than 12 h. Floating tablet was prepared using HPMC (K4M) carbopol 934.
DOI: 10.5281/zenodo.10477328
title: Formulation and In-Vitro Evaluation of Gastroretensive Drug Delivery System of Ritonavir

description: The purpose of the research work was to develop a floating drug delivery system of Ritonavir in order to prolong the gastric residence time and increase its bioavailability. Gastroretensive retentive drug delivery system is designed with the aim to target the drug to its absorption site and to maintain the dosage form at that site for an extended period of time. To develop a floating Mucoadhesive tablet of ritonavir to prolong the gastric retention time for effective drug delivery system. Floating Mucoadhesive tablet of ritonavir was prepared successfully by direct compression method. Compatibility study of ritonavir with formulation ingredients was performed by DSC and FTIR results revealed that drug was compatible with all selected excipients. The present investigation was aimed to formulate floating drug delivery system using effervescent agent sodium bicarbonate and citric acid the tablet continuously floats for more than 12 h. Floating tablet was prepared using HPMC (K4M) carbopol 934.
DOI: 10.6084/m9.figshare.24971955
title: Supplementary Material for: Time for “code ICH”? – Workflow metrics of hyperacute treatments and outcome in patients with intracerebral haemorrhage

description: Introduction: 
Knowledge about uptake and workflow metrics of hyperacute treatments in patients with non-traumatic intracerebral haemorrhage (ICH) in the emergency department are scarce.

Methods: 
Single centre retrospective study of consecutive patients with ICH between 01/2018-08/2020. We assessed uptake and workflow metrics of acute therapies overall and according to referral mode (stroke code, transfer from other hospital or other).

Results: 
We enrolled 332 patients (age 73years, IQR 63-81 and GCS 14 points, IQR 11-15, onset-to-admission-time 284 minutes, IQR 111-708minutes) of whom 101 patients (35%) had lobar haematoma. Mode of referral was stroke code in 129 patients (38%), transfer from other hospital in 143 patients (43%) and arrival by other means in 60 patients (18%).
Overall, 143 of 216 (66%) patients with systolic blood pressure &gt;150mmHG received IV antihypertensive and 67 of 76 (88%) on therapeutic oral anticoagulation received prothrombin complex concentrate treatment (PCC). Forty-six patients (14%) received any neurosurgical intervention within 3 hours of admission. 
Median treatment times from admission to first IV-antihypertensive treatment was 38 minutes (IQR 18-72minutes) and 59 minutes (IQR 37-111 minutes) for PCC, with significant differences according to mode of referral (p&lt;0.001) but not early arrival (≤6hours of onset, p=0.92). The median time in the emergency department was 139 minutes (IQR 85-220 minutes) and among patients with elevated blood pressure, only 44% achieved a successful control (&lt;140mmHG) during ED stay. In multivariate analysis, code ICH concordant treatment was associated with significantly lower odds for in-hopsital mortality (aOR 0.30, 95%CI 0.12-0.73, p=0.008) and a non-significant trends towards better functional outcome measured using the modified Rankin scale score at 3 months (aOR for ordinal shift 0.54 95%CI 0.26-1.12, p=0.097).

Conclusion:
Uptake of hyperacute therapies for ICH treatment in the ED is heterogeneous. Treatment delays are short but not all patients achieve treatment targets during ED stay. Code ICH concordant treatment may improve clinical outcomes. Further improvements seem achievable advocating for a “code ICH” to streamline acute treatments.
DOI: 10.6084/m9.figshare.24971958
title: Supplementary Material for: The association of glaucoma with ischemic stroke and functional outcome after ischemic stroke from the perspective of causality

description: Introduction: Glaucoma may be related to ischemic stroke (IS) and poor outcomes after IS in observational studies, while the causal association remains unclear.
Methods: We obtained single nucleotide polymorphisms (SNPs) related to glaucoma from the gene-wide association study (GWAS) conducted by the FinnGen consortium. The GWAS included a total of 13,614 cases and 295,540 controls. The summary-level of datasets regarding IS were collected from the MEGASTROKE consortium, including 34,217 cases and 406,111 controls. Furthermore, we acquired summary statistics datasets for functional outcomes following IS from the GWAS meta-analysis conducted by the GISCOME consortium, which involved 6,021 individuals. The genetic association estimates for functional outcomes at 90 days after IS were evaluated by the modified Rankin Score (mRS), including 3,741 cases with good functional outcomes (mRS=0-2) and 2,280 subjects with poor functional outcomes post-stroke (mRS=3-6). Inverse variance weighting (IVW) was used as the primary method, complemented by sensitivity analyses for pleiotropy and increasing robustness.
Results: Genetically, glaucoma is associated with an increased risk of IS (odds ratio [OR]=1.08, 95% confidence interval [CI] = 1.02-1.14, P = 0.0039), as well as poor prognosis after IS with adjustment for severity (OR=1.64; 95% CI=1.27-2.13, P=0.0001) and functional outcome after IS (OR=1.45, 95% CI=1.12-1.87, P=0.0038). Through sensitivity analyses, we confirmed the robustness of the results. In addition, we did not identify any causal association between IS, functional outcome after IS, and glaucoma in reverse analysis.
Conclusion: Our study provides evidence suggesting a potential genetic causal relationship between glaucoma and an increased risk of IS, as well as a poor functional outcome following IS. Future studies are necessary to confirm these findings.
DOI: 10.6084/m9.figshare.24971958.v1
title: Supplementary Material for: The association of glaucoma with ischemic stroke and functional outcome after ischemic stroke from the perspective of causality

description: Introduction: Glaucoma may be related to ischemic stroke (IS) and poor outcomes after IS in observational studies, while the causal association remains unclear.
Methods: We obtained single nucleotide polymorphisms (SNPs) related to glaucoma from the gene-wide association study (GWAS) conducted by the FinnGen consortium. The GWAS included a total of 13,614 cases and 295,540 controls. The summary-level of datasets regarding IS were collected from the MEGASTROKE consortium, including 34,217 cases and 406,111 controls. Furthermore, we acquired summary statistics datasets for functional outcomes following IS from the GWAS meta-analysis conducted by the GISCOME consortium, which involved 6,021 individuals. The genetic association estimates for functional outcomes at 90 days after IS were evaluated by the modified Rankin Score (mRS), including 3,741 cases with good functional outcomes (mRS=0-2) and 2,280 subjects with poor functional outcomes post-stroke (mRS=3-6). Inverse variance weighting (IVW) was used as the primary method, complemented by sensitivity analyses for pleiotropy and increasing robustness.
Results: Genetically, glaucoma is associated with an increased risk of IS (odds ratio [OR]=1.08, 95% confidence interval [CI] = 1.02-1.14, P = 0.0039), as well as poor prognosis after IS with adjustment for severity (OR=1.64; 95% CI=1.27-2.13, P=0.0001) and functional outcome after IS (OR=1.45, 95% CI=1.12-1.87, P=0.0038). Through sensitivity analyses, we confirmed the robustness of the results. In addition, we did not identify any causal association between IS, functional outcome after IS, and glaucoma in reverse analysis.
Conclusion: Our study provides evidence suggesting a potential genetic causal relationship between glaucoma and an increased risk of IS, as well as a poor functional outcome following IS. Future studies are necessary to confirm these findings.
DOI: 10.5281/zenodo.10473954
title: ClarTTS Corpus
DOI: 10.5281/zenodo.10473955
title: ClarTTS Corpus
DOI: 10.5281/zenodo.10284230
title: Shape Completion with Prediction of Uncertain Regions

description: Overview

This is the dataset for the publication Shape Completion with Prediction of Uncertain Regions [IEEE][arXiv].

The dataset contains rendered depth images, watertight meshes and occupancy as well as uncertain region labels for the mugs category (03797390) of the ShapeNetCore.v1 dataset.

It further contains optimized, watertight meshes and occupancy as well as uncertain region labels for the mugs found in the HB, LM, TYOL and YCBV datasets from the BOP challenge.

After downloading the shapenet.tar.gz and bop.tar.gz files as well as the original datasets, simply unpack and move the content to the corresponding directories.

Code

Python code for loading of this dataset is provided at the official GitHub repository.

MD5 checksums



bop.tar.gz: a0a54631939fef360482aafcccca77a4

shapenet.tar.gz: 4c96dde625dc7662ad6eacf6f129c55c


Citation

If you find the provided dataset useful in your research, please use the following BibTex entry to cite the corresponding research paper:



@inproceedings{humt2023uncertain,  author={Humt, Matthias and Winkelbauer, Dominik and Hillenbrand, Ulrich},  booktitle={2023 IEEE/RSJ International Conference on Intelligent Robots and Systems (IROS)},   title={Shape Completion with Prediction of Uncertain Regions},   year={2023},  pages={1215-1221},  doi={10.1109/IROS55552.2023.10342487}}
DOI: 10.5281/zenodo.10284229
title: Shape Completion with Prediction of Uncertain Regions

description: Overview

This is the dataset for the publication Shape Completion with Prediction of Uncertain Regions [IEEE][arXiv].

The dataset contains rendered depth images, watertight meshes and occupancy as well as uncertain region labels for the mugs category (03797390) of the ShapeNetCore.v1 dataset.

It further contains optimized, watertight meshes and occupancy as well as uncertain region labels for the mugs found in the HB, LM, TYOL and YCBV datasets from the BOP challenge.

After downloading the shapenet.tar.gz and bop.tar.gz files as well as the original datasets, simply unpack and move the content to the corresponding directories.

Code

Python code for loading of this dataset is provided at the official GitHub repository.

MD5 checksums



bop.tar.gz: a0a54631939fef360482aafcccca77a4

shapenet.tar.gz: 4c96dde625dc7662ad6eacf6f129c55c


Citation

If you find the provided dataset useful in your research, please use the following BibTex entry to cite the corresponding research paper:



@inproceedings{humt2023uncertain,  author={Humt, Matthias and Winkelbauer, Dominik and Hillenbrand, Ulrich},  booktitle={2023 IEEE/RSJ International Conference on Intelligent Robots and Systems (IROS)},   title={Shape Completion with Prediction of Uncertain Regions},   year={2023},  pages={1215-1221},  doi={10.1109/IROS55552.2023.10342487}}
DOI: 10.6084/m9.figshare.24971961
title: Supplementary Material for: A Phase 3 Study of Pembrolizumab Versus Placebo for Previously Treated Patients From Asia With Hepatocellular Carcinoma: Health-Related Quality of Life Analysis From KEYNOTE-394

description: Introduction
KEYNOTE-394 showed pembrolizumab significantly improved overall survival, progression-free survival, and objective response rate with manageable safety versus placebo for patients from Asia with previously treated advanced hepatocellular carcinoma. We present results on health-related quality of life (HRQoL).

Methods
HRQoL was evaluated using the EORTC Quality of Life Questionnaire-Core 30 (EORTC QLQ-C30) and EuroQol-5D-3L (EQ-5D-3L) questionnaires. Key HRQoL endpoints were least squares mean (LSM) score changes from baseline to week 12 and time to deterioration (TTD) for EORTC QLQ-C30 global health status (GHS)/QoL. p values were one-sided and nominal without adjustment for multiplicity.

Results
The HRQoL population included patients randomly assigned to pembrolizumab (n = 298) and placebo (n = 152). From baseline to week 12, a greater decline in EORTC QLQ-C30 GHS/QoL score was observed with placebo (LSM, −8.4; 95% CI: −11.7 to −5.1) versus pembrolizumab (−4.0; 95% CI: −6.4 to −1.6; difference vs placebo: 4.4; 95% CI: 0.5–8.4; nominal p = 0.0142). Similarly, a greater decline in EQ-5D-3L visual analog scale score was observed with placebo (−6.9; 95% CI: −9.4 to −4.5) versus pembrolizumab (−2.7; 95% CI: −4.5 to −1.0; difference vs placebo: 4.2; 95% CI: 1.2–7.2; nominal p = 0.0030). TTD in EORTC QLQ-C30 GHS/QoL score was similar between arms (hazard ratio, 0.85; 95% CI: 0.58–1.25; nominal p = 0.1993).

Conclusion
Patients receiving placebo showed greater decline in HRQoL than those receiving pembrolizumab. Combined with efficacy and safety data from KEYNOTE-394 and the global KEYNOTE-240 and KEYNOTE-224 trials, our data support the clinically meaningful benefit and manageable tolerability of pembrolizumab as second-line therapy for patients with advanced hepatocellular carcinoma.