cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.4629856.v1
title: Supplementary Material for: Dipeptidyl Peptidase-4 Inhibitors in Chronic Kidney Disease: A Systematic Review of Randomized Clinical Trials

description: <b><i>Background:</i></b> Chronic kidney disease (CKD) is common in patients with type 2 diabetes mellitus (T2DM) and limits therapeutic options. Dipeptidyl peptidase-4 (DPP-4) inhibitors represent a novel class of oral glucose-lowering agents and are known to be safe and effective in the general population. <b><i>Methods:</i></b> We searched Cochrane, EMBASE, and PubMed from the time of their inception until March 2015. We included randomized controlled trials analyzing the efficacy (change in hemoglobin A1C [HbA1C]) and safety of DPP-4 agents in individuals with reduced kidney function (estimated glomerular filtration rate &lt;60 mL/min/1.73 m<sup>2</sup>). We extracted study characteristics, participants' baseline characteristics, and safety outcomes from eligible studies. We performed a random effects meta-analysis to summarize the change in HbA1C and the relative risk of cardiovascular events in patients with T2DM and CKD. We also collected data on hypoglycemia, other serious adverse events, and mortality. <b><i>Results:</i></b> We reviewed 12 studies with 4,403 patients with CKD and 239 on dialysis, finding a mean weighted decline in HbA1C of -0.48 (95% CI -0.61 to -0.35) with DPP-4 inhibitor therapy compared to placebo. DPP-4 inhibitors did not result in any additional adverse events, hypoglycemic episodes, or increased mortality. Restricting to studies with low risk of bias did not alter these findings. <b><i>Conclusions:</i></b> DPP-4 inhibitors can lower HbA1C without increasing the risk of cardiovascular or other major adverse events in patients with CKD. Few studies reported critical adverse events such as heart failure and hypersensitivity. If compared with other oral antiglycemic drugs, the effect of DPP-4 inhibitors is limited; however, their low risk of hypoglycemia may favor their use in patients with CKD. <b><i>Summary:</i></b> This systematic review of DPP-4 inhibitors in CKD suggests that they reduce HbA1C by about 0.5%. Furthermore, there was not any increase in the risk for significant adverse events. More research is needed to determine the safety and efficacy of DPP-4 inhibitors in CKD.
DOI: 10.6084/m9.figshare.4629838
title: Supplementary Material for: The Influence of Renal Centre and Patient Sociodemographic Factors on Home Haemodialysis Prevalence in the UK

description: <b><i>Background:</i></b> In the United Kingdom, socioeconomic disadvantage has been associated with lower use of home dialysis, mostly peritoneal dialysis. In this study, we explore the role of a patient's sociodemographic, socioeconomic differences and the centre's influence on home haemodialysis (HD) prevalence. <b><i>Methods:</i></b> Data is derived from the cross-sectional arm of the UK multi-centre study investigating barriers and enablers of home HD (BASIC-HHD study). Centres were classified as low- (&lt;3%), medium- (5-8%) and high-prevalence groups (&gt;8%). Sociodemographic and socioeconomic status data were ascertained. Patients were enrolled in hospital HD (<i>n</i> = 213), home HD (<i>n</i> = 93) and predialysis groups (<i>n</i> = 222). <b><i>Results:</i></b> The treating renal centre to which the patient belonged was significantly associated with a patient's modality in prevalent HD groups and modality-choice in the “predialysis” group, in confounder-adjusted multivariable analyses. Non-white ethnicity was associated with lower odds of self-care dialysis modality choice (OR 0.21, 95% CI 0.07-0.62) and lower odds of home HD uptake in the prevalent HD group (OR 0.24, 95% CI 0.07-0.80). Other significant associations of home HD uptake in the HD cohort included lower age (OR 0.59, 95% CI 0.39-0.89), higher education (OR 2.99, 95% CI 1.25-7.16), home ownership (OR 0.26, 95% CI 0.09-0.70), childcare responsibility (OR 0.22, 95% CI 0.08-0.66) and unrestricted mobility (OR 0.31, 95% CI 0.11-0.91). <b><i>Conclusion:</i></b> “Centre” effect accounts for variation in home HD prevalence between renal units after accounting for sociodemographic parameters and co-morbidities. Unit practices and attitudes to home HD are likely to have a dominating impact on home HD prevalence rates and these aspects need to be explored systematically at the organisational level.
DOI: 10.6084/m9.figshare.4629838.v1
title: Supplementary Material for: The Influence of Renal Centre and Patient Sociodemographic Factors on Home Haemodialysis Prevalence in the UK

description: <b><i>Background:</i></b> In the United Kingdom, socioeconomic disadvantage has been associated with lower use of home dialysis, mostly peritoneal dialysis. In this study, we explore the role of a patient's sociodemographic, socioeconomic differences and the centre's influence on home haemodialysis (HD) prevalence. <b><i>Methods:</i></b> Data is derived from the cross-sectional arm of the UK multi-centre study investigating barriers and enablers of home HD (BASIC-HHD study). Centres were classified as low- (&lt;3%), medium- (5-8%) and high-prevalence groups (&gt;8%). Sociodemographic and socioeconomic status data were ascertained. Patients were enrolled in hospital HD (<i>n</i> = 213), home HD (<i>n</i> = 93) and predialysis groups (<i>n</i> = 222). <b><i>Results:</i></b> The treating renal centre to which the patient belonged was significantly associated with a patient's modality in prevalent HD groups and modality-choice in the “predialysis” group, in confounder-adjusted multivariable analyses. Non-white ethnicity was associated with lower odds of self-care dialysis modality choice (OR 0.21, 95% CI 0.07-0.62) and lower odds of home HD uptake in the prevalent HD group (OR 0.24, 95% CI 0.07-0.80). Other significant associations of home HD uptake in the HD cohort included lower age (OR 0.59, 95% CI 0.39-0.89), higher education (OR 2.99, 95% CI 1.25-7.16), home ownership (OR 0.26, 95% CI 0.09-0.70), childcare responsibility (OR 0.22, 95% CI 0.08-0.66) and unrestricted mobility (OR 0.31, 95% CI 0.11-0.91). <b><i>Conclusion:</i></b> “Centre” effect accounts for variation in home HD prevalence between renal units after accounting for sociodemographic parameters and co-morbidities. Unit practices and attitudes to home HD are likely to have a dominating impact on home HD prevalence rates and these aspects need to be explored systematically at the organisational level.
DOI: 10.6084/m9.figshare.4629793
title: HazMatMapper: an online and interactive geographic visualization tool for exploring transnational flows of hazardous waste and environmental justice

description: HazMatMapper is an online and interactive geographic visualization tool designed to facilitate exploration of transnational flows of hazardous waste in North America (http://geography.wisc.edu/hazardouswaste/map/). While conventional narratives suggest that wealthier countries such as Canada and the United States (US) export waste to poorer countries like Mexico, little is known about how waste trading may affect specific sites within any of the three countries. To move beyond anecdotal discussions and national aggregates, we assembled a novel geographic dataset describing transnational hazardous waste shipments from 2007 to 2012 through two Freedom of Information Act requests for documents held by the US Environmental Protection Agency. While not yet detailing all of the transnational hazardous waste trade in North America, HazMatMapper supports multiscale and site-specific visual exploration of US imports of hazardous waste from Canada and Mexico. It thus enables academic researchers, waste regulators, and the general public to generate hypotheses on regional clustering, transnational corporate structuring, and environmental justice concerns, as well as to understand the limitations of existing regulatory data collection itself. Here, we discuss the dataset and design process behind HazMatMapper and demonstrate its utility for understanding the transnational hazardous waste trade.
DOI: 10.6084/m9.figshare.4629766
title: café joris !

description: coucou
DOI: 10.6084/m9.figshare.4629793.v1
title: HazMatMapper: an online and interactive geographic visualization tool for exploring transnational flows of hazardous waste and environmental justice

description: HazMatMapper is an online and interactive geographic visualization tool designed to facilitate exploration of transnational flows of hazardous waste in North America (http://geography.wisc.edu/hazardouswaste/map/). While conventional narratives suggest that wealthier countries such as Canada and the United States (US) export waste to poorer countries like Mexico, little is known about how waste trading may affect specific sites within any of the three countries. To move beyond anecdotal discussions and national aggregates, we assembled a novel geographic dataset describing transnational hazardous waste shipments from 2007 to 2012 through two Freedom of Information Act requests for documents held by the US Environmental Protection Agency. While not yet detailing all of the transnational hazardous waste trade in North America, HazMatMapper supports multiscale and site-specific visual exploration of US imports of hazardous waste from Canada and Mexico. It thus enables academic researchers, waste regulators, and the general public to generate hypotheses on regional clustering, transnational corporate structuring, and environmental justice concerns, as well as to understand the limitations of existing regulatory data collection itself. Here, we discuss the dataset and design process behind HazMatMapper and demonstrate its utility for understanding the transnational hazardous waste trade.
DOI: 10.6084/m9.figshare.4629760
title: Improving Molecular Diagnosis of Aniridia and WAGR Syndrome Using Customized Targeted Array-Based CGH

description: Chromosomal deletions at 11p13 are a frequent cause of congenital Aniridia, a rare pan-ocular genetic disease, and of WAGR syndrome, accounting up to 30% of cases. First-tier genetic testing for newborn with aniridia, to detect 11p13 rearrangements, includes Multiplex Ligation-dependent Probe Amplification (MLPA) and karyotyping. However, neither of these approaches allow obtaining a complete picture of the high complexity of chromosomal deletions and breakpoints in aniridia. Here, we report the development and validation of a customized targeted array-based comparative genomic hybridization, so called WAGR-array, for comprehensive high-resolution analysis of CNV in the WAGR locus. Our approach increased the detection rate in a Spanish cohort of 38 patients with aniridia, WAGR syndrome and other related ocular malformations, allowing to characterize four undiagnosed aniridia cases, and to confirm MLPA findings in four additional patients. For all patients, breakpoints were accurately established and a contiguous deletion syndrome, involving a large number of genes, was identified in three patients. Moreover, we identified novel microdeletions affecting 3' <i>PAX6</i> regulatory regions in three families with isolated aniridia. This tool represents a good strategy for the genetic diagnosis of aniridia and associated syndromes, allowing for a more accurate CNVs detection, as well as a better delineation of breakpoints. Our results underline the clinical importance of performing exhaustive and accurate analysis of chromosomal rearrangements for patients with aniridia, especially newborns and those without defects in <i>PAX6 </i>after diagnostic screening.
DOI: 10.5281/zenodo.4012468
title: Functional neuroimaging of sensorimotor cortices in postmenopausal women with type 2 diabetes

description: Data from the published manuscript: Gorniak SL, Wagner VE, Vaughn K, et al. Functional neuroimaging of sensorimotor cortices in postmenopausal women with type II diabetes. <em>NPh</em>. 2020;7(3):035007. doi:10.1117/1.NPh.7.3.035007 As public sharing of protected health information, such as date of birth, date of diagnosis, dates of treatment, and other private medical history information pertinent to each participant, may violate HIPAA and the Texas Medical Privacy Act, these data are not be shared to protect patient identity.
DOI: 10.6084/m9.figshare.4629754
title: Decourtye L et al PLoS One 2017-Raw data-IGF-1 Induces GHRH Neuronal Axon Elongation during Early Postnatal Life in Mice.pdf

description: Raw data used for the publication by Decourtye et al PlosOne 2017
DOI: 10.6084/m9.figshare.4629766.v1
title: café joris !

description: coucou
DOI: 10.6084/m9.figshare.4629745
title: Data for figure S16 in the supplement

description: See caption of figure s16 in the supplement
DOI: 10.6084/m9.figshare.4629754.v1
title: Decourtye L et al PLoS One 2017-Raw data-IGF-1 Induces GHRH Neuronal Axon Elongation during Early Postnatal Life in Mice.pdf

description: Raw data used for the publication by Decourtye et al PlosOne 2017
DOI: 10.6084/m9.figshare.4629760.v1
title: Improving Molecular Diagnosis of Aniridia and WAGR Syndrome Using Customized Targeted Array-Based CGH

description: Chromosomal deletions at 11p13 are a frequent cause of congenital Aniridia, a rare pan-ocular genetic disease, and of WAGR syndrome, accounting up to 30% of cases. First-tier genetic testing for newborn with aniridia, to detect 11p13 rearrangements, includes Multiplex Ligation-dependent Probe Amplification (MLPA) and karyotyping. However, neither of these approaches allow obtaining a complete picture of the high complexity of chromosomal deletions and breakpoints in aniridia. Here, we report the development and validation of a customized targeted array-based comparative genomic hybridization, so called WAGR-array, for comprehensive high-resolution analysis of CNV in the WAGR locus. Our approach increased the detection rate in a Spanish cohort of 38 patients with aniridia, WAGR syndrome and other related ocular malformations, allowing to characterize four undiagnosed aniridia cases, and to confirm MLPA findings in four additional patients. For all patients, breakpoints were accurately established and a contiguous deletion syndrome, involving a large number of genes, was identified in three patients. Moreover, we identified novel microdeletions affecting 3' <i>PAX6</i> regulatory regions in three families with isolated aniridia. This tool represents a good strategy for the genetic diagnosis of aniridia and associated syndromes, allowing for a more accurate CNVs detection, as well as a better delineation of breakpoints. Our results underline the clinical importance of performing exhaustive and accurate analysis of chromosomal rearrangements for patients with aniridia, especially newborns and those without defects in <i>PAX6 </i>after diagnostic screening.
DOI: 10.5281/zenodo.4012467
title: Functional neuroimaging of sensorimotor cortices in postmenopausal women with type 2 diabetes

description: Data from the published manuscript: Gorniak SL, Wagner VE, Vaughn K, et al. Functional neuroimaging of sensorimotor cortices in postmenopausal women with type II diabetes. <em>NPh</em>. 2020;7(3):035007. doi:10.1117/1.NPh.7.3.035007 As public sharing of protected health information, such as date of birth, date of diagnosis, dates of treatment, and other private medical history information pertinent to each participant, may violate HIPAA and the Texas Medical Privacy Act, these data are not be shared to protect patient identity.
DOI: 10.6084/m9.figshare.12909485.v1
title: SLA_10May2018

description: Gridded SLA data from cds.climate.copernicus.eu for 10 May 2018.
DOI: 10.6084/m9.figshare.4629739
title: Data for figure S14 glycogen in the supplement

description: See caption of figure S14 in the supplement
DOI: 10.6084/m9.figshare.12909485
title: SLA_10May2018

description: Gridded SLA data from cds.climate.copernicus.eu for 10 May 2018.
DOI: 10.6084/m9.figshare.4629736
title: Data for figure S14 fluxes in the supplement

description: See caption of Figure S14 in the supplement
DOI: 10.6084/m9.figshare.4629736.v1
title: Data for figure S14 fluxes in the supplement

description: See caption of Figure S14 in the supplement
DOI: 10.6084/m9.figshare.4629739.v1
title: Data for figure S14 glycogen in the supplement

description: See caption of figure S14 in the supplement
DOI: 10.6084/m9.figshare.4629745.v1
title: Data for figure S16 in the supplement

description: See caption of figure s16 in the supplement
DOI: 10.6084/m9.figshare.4629721
title: Data for figure 5B of main text and S11 in the supplement

description: See captions of the two figures
DOI: 10.6084/m9.figshare.4629733
title: Data for figure S15 in the supplement

description: See caption of figure S15
DOI: 10.6084/m9.figshare.4629730
title: Data for figure S2 in the supplement

description: See caption of figure S2 in the supplement
DOI: 10.6084/m9.figshare.4629721.v1
title: Data for figure 5B of main text and S11 in the supplement

description: See captions of the two figures
DOI: 10.6084/m9.figshare.4629730.v1
title: Data for figure S2 in the supplement

description: See caption of figure S2 in the supplement
DOI: 10.6084/m9.figshare.4629733.v1
title: Data for figure S15 in the supplement

description: See caption of figure S15
DOI: 10.6084/m9.figshare.4629715
title: Data for Figure 5A of main text

description: See caption of figure 5A in main text
DOI: 10.6084/m9.figshare.4629709
title: Data for Figure 4 of main text

description: See caption of figure 4 in main text
DOI: 10.6084/m9.figshare.4629703
title: Data for figure 3A of main text

description: See caption of figure 3 in main text
DOI: 10.6084/m9.figshare.4629715.v1
title: Data for Figure 5A of main text

description: See caption of figure 5A in main text
DOI: 10.6084/m9.figshare.4629709.v1
title: Data for Figure 4 of main text

description: See caption of figure 4 in main text
DOI: 10.6084/m9.figshare.4629691
title: Data for figure S8 in the supplement

description: See caption of figure S8 in the supplement
DOI: 10.6084/m9.figshare.4629688
title: Data for figure S7 in the supplement

description: See caption of figure S7 in the supplement
DOI: 10.6084/m9.figshare.4629691.v1
title: Data for figure S8 in the supplement

description: See caption of figure S8 in the supplement
DOI: 10.6084/m9.figshare.4629694
title: Data for figures S9 and S10 in the supplement

description: See captions of figures S9 and S10 in the supplement
DOI: 10.6084/m9.figshare.4629685
title: Data for figure S5 in the supplement

description: See caption of figure S5 in the supplement
DOI: 10.6084/m9.figshare.4629694.v1
title: Data for figures S9 and S10 in the supplement

description: See captions of figures S9 and S10 in the supplement
DOI: 10.6084/m9.figshare.4629679
title: Data for figure S4 in the supplement

description: See caption of figure S4 in the supplement
DOI: 10.6084/m9.figshare.4629682
title: Data for figure S6 in the supplement

description: See caption of figure S6 in the supplement
DOI: 10.6084/m9.figshare.4629688.v1
title: Data for figure S7 in the supplement

description: See caption of figure S7 in the supplement
DOI: 10.6084/m9.figshare.4629676
title: Data for figure S3 in the supplement

description: See caption of figure in the supplementary material
DOI: 10.6084/m9.figshare.4629679.v1
title: Data for figure S4 in the supplement

description: See caption of figure S4 in the supplement
DOI: 10.6084/m9.figshare.4629682.v1
title: Data for figure S6 in the supplement

description: See caption of figure S6 in the supplement
DOI: 10.6084/m9.figshare.4629685.v1
title: Data for figure S5 in the supplement

description: See caption of figure S5 in the supplement
DOI: 10.6084/m9.figshare.4629667
title: Data for figure 2A,B,C of main text

description: see caption in main text
DOI: 10.6084/m9.figshare.4629670
title: Supplementary material - López-Escardó et al. 2017 (Scientific Reports)

description: Supplementary material associated to the publication <i>Is single-cell genomics a useful technique to address evolutionary questions? Insights from three Monosiga brevicollis single-cell amplified genomes </i>by Lopez-Escardo et al.
DOI: 10.6084/m9.figshare.4629673
title: Data for figure 2D of main text

description: see caption of figure 2 in main text
DOI: 10.6084/m9.figshare.4629676.v1
title: Data for figure S3 in the supplement

description: See caption of figure in the supplementary material
DOI: 10.6084/m9.figshare.4629673.v1
title: Data for figure 2D of main text

description: see caption of figure 2 in main text
DOI: 10.6084/m9.figshare.4629655
title: Language Contact in the Danish West Indies: Giving Jack His Jacket - soundfiles

description: In <i>Language Contact in the Danish West Indies: Giving Jack His Jacket</i>, Robin Sabino draws on fieldwork with a last speaker and research from a range of disciplines laying bare the crucial roles of community and resistance in creole genesis.
DOI: 10.6084/m9.figshare.4629667.v1
title: Data for figure 2A,B,C of main text

description: see caption in main text
DOI: 10.6084/m9.figshare.4629670.v2
title: Supplementary material - López-Escardó et al. 2017

description: Supplementary material associated to the publication <i>Is single-cell genomics a useful technique to address evolutionary questions? Insights from three Monosiga brevicollis single-cell amplified genomes </i>by Lopez-Escardo et al.
DOI: 10.6084/m9.figshare.4629655.v1
title: Language Contact in the Danish West Indies: Giving Jack His Jacket - soundfiles

description: In <i>Language Contact in the Danish West Indies: Giving Jack His Jacket</i>, Robin Sabino draws on fieldwork with a last speaker and research from a range of disciplines laying bare the crucial roles of community and resistance in creole genesis.
DOI: 10.6084/m9.figshare.4629670.v1
title: Supplementary material - López-Escardó et al. 2017

description: Supplementary material associated to the publication <i>Is single-cell genomics a useful technique to address evolutionary questions? Insights from three Monosiga brevicollis single-cell amplified genomes </i>by Lopez-Escardo et al.
DOI: 10.6084/m9.figshare.12909491.v1
title: SLA_20May2018

description: Gridded SLA data from cds.climate.copernicus.eu for 20 May 2018.
DOI: 10.6084/m9.figshare.12909491
title: SLA_20May2018

description: Gridded SLA data from cds.climate.copernicus.eu for 20 May 2018.
DOI: 10.6084/m9.figshare.4629616
title: Prevention of ovarian hyperstimulation syndrome in a rat model: comparison of the efficacy of tocilizumab with that of ranibizumab, cabergoline, and a gonadotropin-releasing hormone antagonist

description: The aim of the study is to investigate the effects of the interleukin-6 (IL-6) blocker tocilizumab in a hyperstimulated rat model and compare it with ranibizumab, a gonadotropin-releasing hormone antagonist (GnRHA), and cabergoline. Forty-seven rats were randomly divided into the following seven groups: Group 1: OHS; Group 2: OHS+ GnRHA; Group 3: OHS + ranibizumab; Group 4: OHS + cabergoline; Group 5: OHS + low-dose tocilizumab (TL); Group 6: OHS + high-dose tocilizumab (TH); Group 7: sham. Ovarian weight was significantly lower only in the ranibizumab group than in the OHS group. Estrogen levels were significantly lower in the GnRHA group than in the OHS and the treatment groups. Progesterone levels were significantly lower in the ranibizumab, cabergoline, and TL groups than in the OHS group. Among the treatment groups, corpus luteum counts were lower than in the OHS group. Corpus luteum counts were lowest in the tocilizumab groups. IL-6 intensity was lower in all treatment groups than in the OHS group. In the ranibizumab group IL-6 intensity was the lowest. The TL group did not significantly differ from the GnRHA and cabergoline groups regarding IL-6 expression. Ovarian VEGF expression was significantly lower in all treatment groups. For the TL, ranibizumab, and cabergoline groups VEGF intensity was similar. Tocilizumab may be a new strategy for preventing ovarian hyperstimulation syndrome by inhibition of IL-6.