cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.5281/zenodo.6794115
title: Modelling migraine-related features in the nitroglycerin animal model: trigeminal hyperalgesia is associated with affective status and motor behaviour

description: This dataset comprises the findings obtained in the study aimed at exploring the correlation between trigeminal hyperalgesia and affective status or behavioral components in a migraine-specific animal model based on nitroglycerin administration (see article <em>Modelling migraine-related features in the nitroglycerin animal model: trigeminal hyperalgesia is associated with affective status and motor behaviour).</em> In vivo assessments performed in male Sprague-Dawley rats four hours after treatment with nitroglycerin (10mg/kg, i.p.) or its vehicle: - in the open field test were evaluated: time spent (expressed in seconds) in the center of the apparatus as a measure of anxiety; distance (expressed in meters) travelled in the apparatus as a measure of motor behaviour; number of rearings as a measure of exploratory behaviour; time spent in grooming behavior (expressed in seconds) used as nociception index; - evaluation of trigeminal hyperalgesia in the orofacial formalin test: the face rubbing was measured counting the seconds the animal spent grooming the injected area (upper lip, lateral to the nose) with the ipsilateral forepaw or hindpaw 0–3 min (Phase I) or 12–45 min (Phase II) after formalin injection (50 µl, s.c.). The observation time was divided into 15 blocks of 3 min each. <strong>RESULTS</strong> The data analysis shows an inverse correlation between trigeminal hyperalgesia and motor or exploratory behavior, and a positive association with anxiety-like behavior of spontaneous grooming. These findings further expand on the translational value of the migraine-specific model based on nitroglycerin administration and prompt additional parameters that can be investigated to explore the complexity of the disease.
description: Funding: Ricerca Corrente 2017-2019, Ministry of Health (italy)
DOI: 10.5281/zenodo.6794114
title: Modelling migraine-related features in the nitroglycerin animal model: trigeminal hyperalgesia is associated with affective status and motor behaviour

description: This dataset comprises the findings obtained in the study aimed at exploring the correlation between trigeminal hyperalgesia and affective status or behavioral components in a migraine-specific animal model based on nitroglycerin administration (see article <em>Modelling migraine-related features in the nitroglycerin animal model: trigeminal hyperalgesia is associated with affective status and motor behaviour).</em> In vivo assessments performed in male Sprague-Dawley rats four hours after treatment with nitroglycerin (10mg/kg, i.p.) or its vehicle: - in the open field test were evaluated: time spent (expressed in seconds) in the center of the apparatus as a measure of anxiety; distance (expressed in meters) travelled in the apparatus as a measure of motor behaviour; number of rearings as a measure of exploratory behaviour; time spent in grooming behavior (expressed in seconds) used as nociception index; - evaluation of trigeminal hyperalgesia in the orofacial formalin test: the face rubbing was measured counting the seconds the animal spent grooming the injected area (upper lip, lateral to the nose) with the ipsilateral forepaw or hindpaw 0–3 min (Phase I) or 12–45 min (Phase II) after formalin injection (50 µl, s.c.). The observation time was divided into 15 blocks of 3 min each. <strong>RESULTS</strong> The data analysis shows an inverse correlation between trigeminal hyperalgesia and motor or exploratory behavior, and a positive association with anxiety-like behavior of spontaneous grooming. These findings further expand on the translational value of the migraine-specific model based on nitroglycerin administration and prompt additional parameters that can be investigated to explore the complexity of the disease.
description: Funding: Ricerca Corrente 2017-2019, Ministry of Health (italy)
DOI: 10.6084/m9.figshare.21253896
title: Price data for the Philosophical Transactions 1665-2015

description: This spreadsheet gathers all the evidence we have to date on the pricing of the Philosophical Transactions (1665-1886) and its successor series A and B (1887-2015) <br> Any attempt to analyse price trends over a long period of time must note that: <br> Britain used the imperial system of currency (£ s d) until 1970, and then went decimal. <br> The amount of printed material that the Royal Society issued 'per year' or 'per volume' varied considerably, and this is often the cause of the price variation (rather than, for instance, increases in the price of paper or printing). <br> The Royal Society did not set its prices 'per year' until 1986. Prices before 1986 may be 'per issue', 'per six-monthly part' or 'per volume' (and there may be multiple volumes per year, or fractional volumes per year). <br> The first tab in this workbook collates information on the prices of the 'parts' of the Transactions 1665-1886. <br> The second tab recalculates that data, where possible, into a 'price for a year's-worth of printed matter' <br> The third and fourth tabs give price data for Transactions A and Transactions B after 1887. In each tab, there is a conversion to 'price for a year's worth of printed matter'. <br> The sources from which these prices are gathered are eclectic. The Royal Society has no master list of prices. Occasionally, prices were mentioned in the Royal Society Council Minutes (RS/CMO or RS/CMP) Other useful sources at the Royal Society were the Domestic Manuscripts series (for early modern prices) and various publishing reviews in the 20th century <br> The ledgers of the Taylor & Francis archive were useful for the period when T&F printed for the Royal Society (i.e. 1828-77) The English Catalogue of Books (ECB) was useful for the late nineteenth century
DOI: 10.6084/m9.figshare.21252837.v1
title: Kholod_J_Appendices_Verbal markers of rethinking.docx

description: <em>The purpose of the study was to identify the specifics of the verbal marking of the processes of rethinking the existential values ​​of Ukrainians of various ages thanks to media mediatization and the identification of specific markers of the mentioned processes that took place as a reaction to the large-scale aggression of the Russian Federation against Ukraine as of June 6–14 (the fourth month of the war) of 2022 and on July 9–17 (the fifth month of the war) of 2022.</em> <em>The research methodology consisted of several procedures: 1) the survey was carried out in two stages: the 1st stage – from June 6 to 14, 2022 and from July 9 to 17, 2022 thanks to the electronic program «Google forms» (Mediatization of the population, 2022, September 3 ); 2) at the first stage, 28 people aged 18 to 55 took part in the survey, who lived at the time of the survey in the following regions and cities: Ivano-Frankivsk region, Ivano-Frankivsk city, Kyiv region, outside Ukraine; 3) at the second stage, 51 respondents aged from 18 to 69 who lived in 28 settlements in seven countries of the world (Ukraine, Canada, Poland, Italy, Czech Republic, Turkey) were interviewed; 4) 89 respondents (in two stages of the survey) were asked to familiarize themselves with the definition of the term «media mediatization», answer 2 questions and complete 2 tasks; question 1 – «What were your life values ​​BEFORE February 24, 2022? Describe», question 2 – «What are your life values ​​now AFTER exposure to mediatization? Describe»; 5) the obtained results of the survey in two stages were interpreted in tables and diagrams, which we provided in the electronic resources of international repositories «Mendeley», SSRN and «Figshare».</em> <em>Conclusions. The specificity of the verbal marking of the reinterpretation of the existential values ​​of Ukrainians due to the media mediatization recorded in June and July 2022 of the aforementioned aggression was identified. Such specificity should be considered the functioning of nine (at the first stage) and eight (at the second stage) different psycholinguistic models in the world picture of Ukrainian respondents of different ages, which were explained by eight (at the first stage) and thirteen (at the second stage) verbal markers.</em>
DOI: 10.6084/m9.figshare.21252837
title: Kholod_J_Appendices_Verbal markers of rethinking.docx

description: <em>The purpose of the study was to identify the specifics of the verbal marking of the processes of rethinking the existential values ​​of Ukrainians of various ages thanks to media mediatization and the identification of specific markers of the mentioned processes that took place as a reaction to the large-scale aggression of the Russian Federation against Ukraine as of June 6–14 (the fourth month of the war) of 2022 and on July 9–17 (the fifth month of the war) of 2022.</em> <em>The research methodology consisted of several procedures: 1) the survey was carried out in two stages: the 1st stage – from June 6 to 14, 2022 and from July 9 to 17, 2022 thanks to the electronic program «Google forms» (Mediatization of the population, 2022, September 3 ); 2) at the first stage, 28 people aged 18 to 55 took part in the survey, who lived at the time of the survey in the following regions and cities: Ivano-Frankivsk region, Ivano-Frankivsk city, Kyiv region, outside Ukraine; 3) at the second stage, 51 respondents aged from 18 to 69 who lived in 28 settlements in seven countries of the world (Ukraine, Canada, Poland, Italy, Czech Republic, Turkey) were interviewed; 4) 89 respondents (in two stages of the survey) were asked to familiarize themselves with the definition of the term «media mediatization», answer 2 questions and complete 2 tasks; question 1 – «What were your life values ​​BEFORE February 24, 2022? Describe», question 2 – «What are your life values ​​now AFTER exposure to mediatization? Describe»; 5) the obtained results of the survey in two stages were interpreted in tables and diagrams, which we provided in the electronic resources of international repositories «Mendeley», SSRN and «Figshare».</em> <em>Conclusions. The specificity of the verbal marking of the reinterpretation of the existential values ​​of Ukrainians due to the media mediatization recorded in June and July 2022 of the aforementioned aggression was identified. Such specificity should be considered the functioning of nine (at the first stage) and eight (at the second stage) different psycholinguistic models in the world picture of Ukrainian respondents of different ages, which were explained by eight (at the first stage) and thirteen (at the second stage) verbal markers.</em>
DOI: 10.6084/m9.figshare.20263669.v1
title: Landscape of B Cell Receptor Repertoires in COVID-19 Patients Revealed Through CDR3 Sequencing of Immunoglobulin Heavy and Light Chains

description: The outbreak and persistence of coronavirus disease 2019 (COVID-19) threaten human health. B cells play a vital role in fighting the infections caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Despite many studies on the immune responses in COVID-19 patients, it is still unclear how B cell receptor (BCR) constituents, including immunoglobulin heavy (IGHs) and light chains (IGLs), respond to SARS-CoV-2 in patients with varying symptoms. In this study, we conducted complementarity-determining region 3 (CDR3) sequencing of BCR IGHs and IGLs from the peripheral blood of COVID-19 patients and healthy donors. The results showed significantly reduced clonal diversity, more expanded clones, and longer CDR3 lengths of IGH and IGL in COVID-19 patients than those in healthy individuals. The IGLs had a much higher percentage of VJ skew usage (47.83% IGLV and 42.86% IGLJ were significantly regulated) than the IGHs (12.09% IGHV and 0% IGHJ) between the healthy individuals and patients, which indicated the importance of BCR light chains. Furthermore, we found a largely expanded <i>IGLV3-25</i> gene cluster mostly pairing with <i>IGLJ1</i> and <i>ILGJ2</i> in COVID-19 patients and a newly identified upregulated <i>IGLJ1</i> gene and <i>IGLJ2</i>+<i>IGLV13-21</i> recombination, both of which are potential sources of SARS-CoV-2-targeting antibodies. Our findings on specific immune B-cell signatures associated with COVID-19 have clinical implications for vaccine and biomarker development for disease diagnosis.
DOI: 10.6084/m9.figshare.20263669
title: Landscape of B Cell Receptor Repertoires in COVID-19 Patients Revealed Through CDR3 Sequencing of Immunoglobulin Heavy and Light Chains

description: The outbreak and persistence of coronavirus disease 2019 (COVID-19) threaten human health. B cells play a vital role in fighting the infections caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Despite many studies on the immune responses in COVID-19 patients, it is still unclear how B cell receptor (BCR) constituents, including immunoglobulin heavy (IGHs) and light chains (IGLs), respond to SARS-CoV-2 in patients with varying symptoms. In this study, we conducted complementarity-determining region 3 (CDR3) sequencing of BCR IGHs and IGLs from the peripheral blood of COVID-19 patients and healthy donors. The results showed significantly reduced clonal diversity, more expanded clones, and longer CDR3 lengths of IGH and IGL in COVID-19 patients than those in healthy individuals. The IGLs had a much higher percentage of VJ skew usage (47.83% IGLV and 42.86% IGLJ were significantly regulated) than the IGHs (12.09% IGHV and 0% IGHJ) between the healthy individuals and patients, which indicated the importance of BCR light chains. Furthermore, we found a largely expanded <i>IGLV3-25</i> gene cluster mostly pairing with <i>IGLJ1</i> and <i>ILGJ2</i> in COVID-19 patients and a newly identified upregulated <i>IGLJ1</i> gene and <i>IGLJ2</i>+<i>IGLV13-21</i> recombination, both of which are potential sources of SARS-CoV-2-targeting antibodies. Our findings on specific immune B-cell signatures associated with COVID-19 have clinical implications for vaccine and biomarker development for disease diagnosis.
DOI: 10.18112/openneuro.ds004283.v1.0.1
title: neuroloki
DOI: 10.6084/m9.figshare.21253956
title: Price data for Proceedings of the Royal Society, 1831-2015

description: This spreadsheet gathers all the evidence we have to date on the pricing of the Proceedings of the Royal Society (1831-1905) and its successor series A and B (1905-2015) <br> Any attempt to analyse price trends over a long period of time must note that: <br> Britain used the imperial system of currency (£ s d) until 1970, and then went decimal. <br> The amount of printed material that the Royal Society issued 'per year' or 'per volume' varied considerably, and this is often the cause of the price variation (rather than, for instance, increases in the price of paper or printing). <br> The Royal Society did not set its prices 'per year' until 1986. Prices before 1986 may be 'per issue' or 'per volume' (and there may be multiple volumes per year, or fractional volumes per year). <br> The first tab in this workbook collates information on the prices of the 'volumes' of the Proceedings 1831-1905. A separate pair of columns recalculate that data, where possible, into a 'price for a year's-worth of printed matter' <br> The second and third tabs give price data for Proceedings A and Proceedings B after 1905. In each tab, there is a conversion to 'price for a year's worth of printed matter'. There is also a column showing the prices adjusted for inflation (normalised to 2010£) <br> The final tab has the deflation adjuster data, from MeasuringWorth.com <br> The sources from which these prices are gathered are eclectic. The Royal Society has no master list of prices. Occasionally, prices were mentioned in the Royal Society Council Minutes (RS/CMO or RS/CMP) The ledgers of the Taylor & Francis archive were useful for the period when T&F printed for the Royal Society (i.e. 1828-77) The English Catalogue of Books (ECB) was useful for the late nineteenth century
DOI: 10.6084/m9.figshare.21253956.v2
title: Price data for Proceedings of the Royal Society, 1831-2015

description: This spreadsheet gathers all the evidence we have to date on the pricing of the Proceedings of the Royal Society (1831-1905) and its successor series A and B (1905-2015) <br> Any attempt to analyse price trends over a long period of time must note that: <br> Britain used the imperial system of currency (£ s d) until 1970, and then went decimal. <br> The amount of printed material that the Royal Society issued 'per year' or 'per volume' varied considerably, and this is often the cause of the price variation (rather than, for instance, increases in the price of paper or printing). <br> The Royal Society did not set its prices 'per year' until 1986. Prices before 1986 may be 'per issue' or 'per volume' (and there may be multiple volumes per year, or fractional volumes per year). <br> The first tab in this workbook collates information on the prices of the 'volumes' of the Proceedings 1831-1905. A separate pair of columns recalculate that data, where possible, into a 'price for a year's-worth of printed matter' <br> The second and third tabs give price data for Proceedings A and Proceedings B after 1905. In each tab, there is a conversion to 'price for a year's worth of printed matter'. There is also a column showing the prices adjusted for inflation (normalised to 2010£) <br> The final tab has the deflation adjuster data, from MeasuringWorth.com <br> The sources from which these prices are gathered are eclectic. The Royal Society has no master list of prices. Occasionally, prices were mentioned in the Royal Society Council Minutes (RS/CMO or RS/CMP) The ledgers of the Taylor & Francis archive were useful for the period when T&F printed for the Royal Society (i.e. 1828-77) The English Catalogue of Books (ECB) was useful for the late nineteenth century
DOI: 10.6084/m9.figshare.21253956.v1
title: Untitled Item

description: This spreadsheet gathers all the evidence we have to date on the pricing of the Proceedings of the Royal Society (1831-1905) and its successor series A and B (1905-2015) <br> Any attempt to analyse price trends over a long period of time must note that: <br> Britain used the imperial system of currency (£ s d) until 1970, and then went decimal. <br> The amount of printed material that the Royal Society issued 'per year' or 'per volume' varied considerably, and this is often the cause of the price variation (rather than, for instance, increases in the price of paper or printing). <br> The Royal Society did not set its prices 'per year' until 1986. Prices before 1986 may be 'per issue' or 'per volume' (and there may be multiple volumes per year, or fractional volumes per year). <br> The first tab in this workbook collates information on the prices of the 'volumes' of the Proceedings 1831-1905. A separate pair of columns recalculate that data, where possible, into a 'price for a year's-worth of printed matter' <br> The second and third tabs give price data for Proceedings A and Proceedings B after 1905. In each tab, there is a conversion to 'price for a year's worth of printed matter'. There is also a column showing the prices adjusted for inflation (normalised to 2010£) <br> The final tab has the deflation adjuster data, from MeasuringWorth.com <br> The sources from which these prices are gathered are eclectic. The Royal Society has no master list of prices. Occasionally, prices were mentioned in the Royal Society Council Minutes (RS/CMO or RS/CMP) The ledgers of the Taylor & Francis archive were useful for the period when T&F printed for the Royal Society (i.e. 1828-77) The English Catalogue of Books (ECB) was useful for the late nineteenth century
DOI: 10.6084/m9.figshare.21253968
title: Chapter_6_refinement_A526_61306

description: Rietveld refinement of a neutron diffraction pattern.
DOI: 10.6084/m9.figshare.21253968.v1
title: Chapter_6_refinement_A526_61306

description: Rietveld refinement of a neutron diffraction pattern.
DOI: 10.25934/pr00007503
title: systematic review and meta-analysis Heme Malignancy VTE anticoagulation

description: Narrative summary explaining the relevance of the project to science and public health
Background
Venous thromboembolism (VTE) is a major cause of morbidity and mortality in patients with cancer. Although the relative risk of VTE in cancer patients is up to 50-fold higher than in patients without cancer, the absolute risk varies depending on the subtype of cancer and the cancer treatment, and patient-related factors. The risks of VTE recurrence and bleeding during antithrombotic treatment (also called "blood thinners", medications that help treat blood clots) for cancer-associated VTE are also higher than in non-cancer patients but vary with each cancer subtype. 
Patients with hematologic malignancies, cancers that arise from blood cells like lymphoma or leukemia, represent a diverse group with different thrombosis and bleeding risks. They are typically underrepresented in the few randomized controlled trials evaluating anticoagulant therapy in cancer patients. Consequently, management of blood clots in patients with blood cancers (hematologic malignancy) is typically extrapolated from results based largely on patients with solid tumors, but these populations have many differences including hospitalization rates, risk of infection, use of indwelling catheters, multi-drug treatments with potentially critical drug-drug interactions, and higher likelihood of severe cytopenias that may complicate blood clot management.  
The restricted inclusion of hematologic malignancies in thrombosis treatment studies has led to a knowledge deficit regarding anticoagulant safety and efficacy, and thus, optimum management for these patients remains unknown.  More precise risk estimates regarding efficacy and safety of anticoagulant modalities in patients with hematologic malignancies may provide valuable information to clinicians that have critical impact on patient outcomes. A systematic review with individual patient-level meta-analysis on treatment of acute VTE in patients with hematologic malignancies can help narrow this knowledge gap.
DOI: 10.18112/openneuro.ds004283.v1.0.2
title: neuroloki
DOI: 10.6084/m9.figshare.21253974
title: bd_data

description: Data set of tadpoles infectec by chytrid fungus and ranavirus.
DOI: 10.6084/m9.figshare.21253974.v1
title: bd_data

description: Data set of tadpoles infectec by chytrid fungus and ranavirus.