cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.8288249.v1
title: Additional file 15: of Isolated C. elegans germ nuclei exhibit distinct genomic profiles of histone modification and gene expression

description: SOM_H3K4me3_q0.001_peaks_ce10 (XLSX 4603 kb)
DOI: 10.6084/m9.figshare.8288243.v1
title: Additional file 14: of Isolated C. elegans germ nuclei exhibit distinct genomic profiles of histone modification and gene expression

description: IGN_H3K4me3_q0.001_peaks_ce10 (XLSX 3928 kb)
DOI: 10.6084/m9.figshare.8288234
title: Additional file 13: of Isolated C. elegans germ nuclei exhibit distinct genomic profiles of histone modification and gene expression

description: SOM_H3K27ac_q0.001_peaks_ce10 (XLSX 5600 kb)
DOI: 10.6084/m9.figshare.8288234.v1
title: Additional file 13: of Isolated C. elegans germ nuclei exhibit distinct genomic profiles of histone modification and gene expression

description: SOM_H3K27ac_q0.001_peaks_ce10 (XLSX 5600 kb)
DOI: 10.6084/m9.figshare.8288225
title: Additional file 12: of Isolated C. elegans germ nuclei exhibit distinct genomic profiles of histone modification and gene expression

description: IGN_H3K27ac_q0.001_peaks_ce10 (XLSX 5606 kb)
DOI: 10.6084/m9.figshare.8288216
title: Additional file 11: of Isolated C. elegans germ nuclei exhibit distinct genomic profiles of histone modification and gene expression

description: IGN transcripts compared to other datasests (XLSX 3951 kb)
DOI: 10.6084/m9.figshare.8288225.v1
title: Additional file 12: of Isolated C. elegans germ nuclei exhibit distinct genomic profiles of histone modification and gene expression

description: IGN_H3K27ac_q0.001_peaks_ce10 (XLSX 5606 kb)
DOI: 10.6084/m9.figshare.8288216.v1
title: Additional file 11: of Isolated C. elegans germ nuclei exhibit distinct genomic profiles of histone modification and gene expression

description: IGN transcripts compared to other datasests (XLSX 3951 kb)
DOI: 10.6084/m9.figshare.8288201
title: Additional file 10: of Isolated C. elegans germ nuclei exhibit distinct genomic profiles of histone modification and gene expression

description: IGN and soma RNA-seq expression analysis (XLSX 4868 kb)
DOI: 10.6084/m9.figshare.8288201.v1
title: Additional file 10: of Isolated C. elegans germ nuclei exhibit distinct genomic profiles of histone modification and gene expression

description: IGN and soma RNA-seq expression analysis (XLSX 4868 kb)
DOI: 10.6084/m9.figshare.8288084
title: GAD67 & Iba1 abutments measurements 8209 GP 2

description: GAD67 & Iba1 abutments measurements 8209 GP 2 2019 paper
DOI: 10.6084/m9.figshare.8288084.v1
title: GAD67 & Iba1 abutments measurements 8209 GP 2

description: GAD67 & Iba1 abutments measurements 8209 GP 2 2019 paper
DOI: 10.6084/m9.figshare.8288069
title: Supplementary Material for: Primary Hypertrophic Osteoarthropathy Mimicking Juvenile Idiopathic Arthritis: A Novel SLCO2A1 Mutation and Imaging Findings

description: Primary hypertrophic osteoarthropathy (PHO), also known as pachydermoperiostosis, is a rare, multisystemic, autosomal recessive condition typically presenting with digital clubbing, osteoarthropathy, and various skin manifestations. Radiographs show distinctive periosteal reaction and thickening along the long bones. PHO is caused by homozygous mutations in the <i>HPGD</i> gene in chromosome 4q34.1 or the <i>SLCO2A1</i> gene in 3q22.1q22.2. Here, we report on a 20-year-old male with enlarged and swollen joints with arthralgia, palmoplantar hyperhidrosis, and large hands and feet with marked digital clubbing. We also present radiographic, MRI, and ultrasonographic features of the case. These clinical and imaging findings were compatible with the diagnosis of PHO, and a novel homozygous mutation, c.576C&gt;G, p.Ile192Met, was found in <i>SLCO2A1.</i>
DOI: 10.6084/m9.figshare.8288060
title: Supplementary Material for: Comparison of DNA Extraction Efficiency and Reproducibility of Different Aeration Diffuser Biofilms Using Bead-Beating Protocol

description: An existing bead-beating DNA extraction protocol was employed to compare the DNA extraction recovery and fragment quality of 6 different aeration diffuser biofilms. <i>Escherichia coli</i>, <i>Gordonia amarae</i>, and mixed liquor were used as controls. The fraction of total DNA<sub>biofilm</sub> decreased monotonically with increasing number of beat beatings (BB) when the amount of DNA present was sufficient (&gt;4 μg<sub>DNA</sub>/cm<sup>2</sup>), excluding the ceramic disk. While controls required only 2 BBs, 3 out of 5 BBs achieved ≥70% of total DNA (70.3 ± 1.7%) for 5 out of 6 biofilms. Quantitative polymerase chain reaction (PCR) analyses of 353 and 1,505 basepair (bp) amplicons from pure culture extracts showed target copy numbers were not degraded for the first 2 BBs, but the third BB decreased amplicon concentrations by 0.65 and 1.12 log for <i>E. coli</i>, and 0.39 and 0.40 log for <i>G. amarae</i>, respectively. The 353 bp fragment amplification from biofilm samples showed minimal degradation for the first 3 BBs. PCR and gel electrophoresis confirmed integrity of amplified 1,505 bp DNA fragments over the 5 BBs, except in the EDPM (75 mm diameter, tube) diffuser biofilm (4.98 ± 0.62 μg<sub>DNA</sub>/cm<sup>2</sup>). Taken together, this study showed type of diffuser membrane biofilms had no effects on extraction efficiency, but low DNA concentrations reduced extraction performance.
DOI: 10.6084/m9.figshare.8288069.v1
title: Supplementary Material for: Primary Hypertrophic Osteoarthropathy Mimicking Juvenile Idiopathic Arthritis: A Novel SLCO2A1 Mutation and Imaging Findings

description: Primary hypertrophic osteoarthropathy (PHO), also known as pachydermoperiostosis, is a rare, multisystemic, autosomal recessive condition typically presenting with digital clubbing, osteoarthropathy, and various skin manifestations. Radiographs show distinctive periosteal reaction and thickening along the long bones. PHO is caused by homozygous mutations in the <i>HPGD</i> gene in chromosome 4q34.1 or the <i>SLCO2A1</i> gene in 3q22.1q22.2. Here, we report on a 20-year-old male with enlarged and swollen joints with arthralgia, palmoplantar hyperhidrosis, and large hands and feet with marked digital clubbing. We also present radiographic, MRI, and ultrasonographic features of the case. These clinical and imaging findings were compatible with the diagnosis of PHO, and a novel homozygous mutation, c.576C&gt;G, p.Ile192Met, was found in <i>SLCO2A1.</i>
DOI: 10.6084/m9.figshare.8288048
title: Non adiabatic coupling matrix element from Photodissociation as a probe of the H<sup>+</sup><sub>3</sub> avoided crossing seam

description: This table gives the non-adiabatic coupling matrix element between the ground and first excited state of H3+, as shown in figure 1
DOI: 10.6084/m9.figshare.8288045
title: Kinetic energy release spectra from Photodissociation as a probe of the H<sup>+</sup><sub>3</sub> avoided crossing seam

description: This table gives the kinetic energy release spectra for the H2+ + H and H2 + H+ channels, as shown in figure 4
DOI: 10.6084/m9.figshare.8288048.v1
title: Non adiabatic coupling matrix element from Photodissociation as a probe of the H<sup>+</sup><sub>3</sub> avoided crossing seam

description: This table gives the non-adiabatic coupling matrix element between the ground and first excited state of H3+, as shown in figure 1
DOI: 10.6084/m9.figshare.8288039
title: ReadMe from Photodissociation as a probe of the H<sup>+</sup><sub>3</sub> avoided crossing seam

description: This file contains the description of the supplementary material
DOI: 10.6084/m9.figshare.8288042
title: Adiabatic potential energy surfaces from Photodissociation as a probe of the H<sup>+</sup><sub>3</sub> avoided crossing seam

description: This table gives the adiabatic potential energy surfaces for the ground and first excited states of H3+, as shown in figure 1
DOI: 10.6084/m9.figshare.8288045.v1
title: Kinetic energy release spectra from Photodissociation as a probe of the H<sup>+</sup><sub>3</sub> avoided crossing seam

description: This table gives the kinetic energy release spectra for the H2+ + H and H2 + H+ channels, as shown in figure 4
DOI: 10.6084/m9.figshare.8288039.v1
title: ReadMe from Photodissociation as a probe of the H<sup>+</sup><sub>3</sub> avoided crossing seam

description: This file contains the description of the supplementary material
DOI: 10.6084/m9.figshare.8288042.v1
title: Adiabatic potential energy surfaces from Photodissociation as a probe of the H<sup>+</sup><sub>3</sub> avoided crossing seam

description: This table gives the adiabatic potential energy surfaces for the ground and first excited states of H3+, as shown in figure 1
DOI: 10.6084/m9.figshare.8288006
title: Supplementary Material for: Improvements in Body Composition after 4 Years of Growth Hormone Treatment in Adult-Onset Hypopituitarism Compared to Age-Matched Controls

description: <b><i>Background/Aims:</i></b> It is unknown whether long-term growth hormone replacement therapy (GHRT) affects body composition in an age- or sex-dependent manner. We aimed to study the effects of 4 years of GHRT on body composition in a large cohort of patients with hypopituitarism compared to a reference population matched by age and sex. <b><i>Methods:</i></b> A total of 964 GH-deficient adults from KIMS (Pfizer International Metabolic Database) with adult-onset hypopituitarism, adequately replaced with all pituitary hormones except for GH at baseline were included. A random sample of the general population (2,301 subjects) from a similar time period was used as reference. Patients and controls were grouped by sex in 5 age cohorts of 10 years. Main outcome measures were changes in BMI and waist circumference after 4 years of GHRT. <b><i>Results:</i></b> In younger patients (28–47 years), 4 years of GHRT resulted in a BMI increase similar to that observed in the reference population, but older patients (48–67 years) had significantly less BMI increase than age-matched healthy controls. Significant differences were seen in waist circumference in patients of all age cohorts who showed virtually no change after 4 years of GHRT compared to approximately 4 cm of increase in the reference population. <b><i>Conclusion:</i></b> Four years of GHRT resulted in improvements in BMI and waist circumference in patients with adult-onset hypopituitarism compared to age-matched controls observed during the same follow-up time. Despite these beneficial effects on body composition, BMI and waist circumference remained higher in patients on GHRT compared to healthy controls.
DOI: 10.6084/m9.figshare.8287964
title: ODE file for simulation in XPPAUT from Geometric analysis of synchronization in neuronal networks with global inhibition and coupling delays

description: We study synaptically coupled neuronal networks to identify the role of coupling delays in network synchronized behaviour. We consider a network of excitable, relaxation oscillator neurons where two distinct populations, one excitatory and one inhibitory are coupled with time-delayed synapses. The excitatory population is uncoupled, while the inhibitory population is tightly coupled without time delay. A geometric singular perturbation analysis yields existence and stability conditions for periodic solutions where the excitatory cells are synchronized and different phase relationships between the excitatory and inhibitory populations can occur, along with formulae for the periods of such solutions. In particular, we show that if there are no delays in the coupling oscillations where the excitatory population is synchronized cannot occur. Numerical simulations are conducted to supplement and validate the analytical results. The analysis helps to explain how coupling delays in either excitatory or inhibitory synapses contribute to producing synchronized rhythms.This article is part of the theme issue ‘Nonlinear dynamics of delay systems’.
DOI: 10.6084/m9.figshare.8287964.v1
title: ODE file for simulation in XPPAUT from Geometric analysis of synchronization in neuronal networks with global inhibition and coupling delays

description: We study synaptically coupled neuronal networks to identify the role of coupling delays in network synchronized behaviour. We consider a network of excitable, relaxation oscillator neurons where two distinct populations, one excitatory and one inhibitory are coupled with time-delayed synapses. The excitatory population is uncoupled, while the inhibitory population is tightly coupled without time delay. A geometric singular perturbation analysis yields existence and stability conditions for periodic solutions where the excitatory cells are synchronized and different phase relationships between the excitatory and inhibitory populations can occur, along with formulae for the periods of such solutions. In particular, we show that if there are no delays in the coupling oscillations where the excitatory population is synchronized cannot occur. Numerical simulations are conducted to supplement and validate the analytical results. The analysis helps to explain how coupling delays in either excitatory or inhibitory synapses contribute to producing synchronized rhythms.This article is part of the theme issue ‘Nonlinear dynamics of delay systems’.
DOI: 10.6084/m9.figshare.8287898
title: Dependence of cell doubling time on generation number for old pole and new pole daughter cells.

description: a) Old pole daughter cells took longer to divide than new pole daughter cells (our linear mixed model analysis returned χ2df=1 =5.192, p = 0.023). For both cell types, division time progressively increased over successive generations (our linear mixed model analysis returned χ2df=1 = 38.327, p &lt; 0.001). This analysis was carried out including data for generations 2 to 11 from two experimental runs.<br>(b) Inspecting the 24-generation data set revealed that the progressive increase in division times gradually asymptotes to a steady state division time with increasing generation number (LMM: linear effect of generation number: χ2df=1 = 52.199, p &lt; 0.001; quadratic effect of generation number: χ2df=1 = 32.832, p &lt; 0.001). Old pole daughter cells also took longer to divide than new pole daughter cells within this 24-generation data set (LMM: χ2df=1 = 11.222, p = 0&lt;0.001). <br>
DOI: 10.6084/m9.figshare.8287850
title: Supplementary Material for: Determinants of Patient Delay in Transient Ischemic Attack

description: <b><i>Introduction:</i></b> Early diagnosis and stroke preventive treatment in patients with transient ischemic attack (TIA) are crucial, but hampered by delayed reporting of symptoms. Previous studies on causes of patient delay provided inconsistent results. We aimed to assess determinants of patient delay among patients with symptoms suggestive of TIA. <b><i>Methods:</i></b> We interviewed participants referred by their general practitioner to an outpatient TIA clinic within 72 h from symptom onset. We determined (i) the exact time from symptom onset to the first contact with a medical service (patient delay); (ii) demographic and clinical characteristics; (iii) patient’s initial perception, and reaction to symptoms; and (iv) patient’s knowledge about TIA. We used multivariable linear regression to identify determinants of patient delay. <b><i>Results:</i></b> We interviewed 202 suspected TIA patients (mean age 67.7 (SD 13.7) years, 111 (55.0%) male), of whom 123 (60.9%) received a definite diagnosis of TIA or minor stroke. Median patient delay was 1.5 (interquartile range 0.4–14.6) hours. Of all patients, 119 (58.9%) considered a TIA (or stroke) as the cause of their symptoms. Among them, 30 (25.2%) thought it was a medical emergency, while of the 83 not considering TIA as the cause of symptoms 38 (45.8%) thought of a medical emergency. Independently related to increased delay were (i) symptom onset out of hours, (ii) absence of dysarthria, (iii) being unaware that TIA requires urgent treatment, (iv) not considering the event an emergency, and (v) knowledge of TIA symptoms. Results for patients with a definite diagnosis of TIA/minor stroke were similar to those with alternative diagnoses. <b><i>Conclusion:</i></b> Patients still tend to wait till office hours to report TIA symptoms. Speech difficulties, and specifically dysarthria, are related to shorter delay. To reduce patient delay, awareness of TIA symptoms should increase and more importantly lay people should be educated to consider a TIA an emergency.
DOI: 10.6084/m9.figshare.8287898.v2
title: Dependence of cell doubling time on generation number for old pole and new pole daughter cells.

description: a) Old pole daughter cells took longer to divide than new pole daughter cells (our linear mixed model analysis returned χ2df=1 =5.192, p = 0.023). For both cell types, division time progressively increased over successive generations (our linear mixed model analysis returned χ2df=1 = 38.327, p &lt; 0.001). This analysis was carried out including data for generations 2 to 11 from two experimental runs.<br>(b) Inspecting the 24-generation data set revealed that the progressive increase in division times gradually asymptotes to a steady state division time with increasing generation number (LMM: linear effect of generation number: χ2df=1 = 52.199, p &lt; 0.001; quadratic effect of generation number: χ2df=1 = 32.832, p &lt; 0.001). Old pole daughter cells also took longer to divide than new pole daughter cells within this 24-generation data set (LMM: χ2df=1 = 11.222, p = 0&lt;0.001). <br>
DOI: 10.6084/m9.figshare.8287850.v1
title: Supplementary Material for: Determinants of Patient Delay in Transient Ischemic Attack

description: <b><i>Introduction:</i></b> Early diagnosis and stroke preventive treatment in patients with transient ischemic attack (TIA) are crucial, but hampered by delayed reporting of symptoms. Previous studies on causes of patient delay provided inconsistent results. We aimed to assess determinants of patient delay among patients with symptoms suggestive of TIA. <b><i>Methods:</i></b> We interviewed participants referred by their general practitioner to an outpatient TIA clinic within 72 h from symptom onset. We determined (i) the exact time from symptom onset to the first contact with a medical service (patient delay); (ii) demographic and clinical characteristics; (iii) patient’s initial perception, and reaction to symptoms; and (iv) patient’s knowledge about TIA. We used multivariable linear regression to identify determinants of patient delay. <b><i>Results:</i></b> We interviewed 202 suspected TIA patients (mean age 67.7 (SD 13.7) years, 111 (55.0%) male), of whom 123 (60.9%) received a definite diagnosis of TIA or minor stroke. Median patient delay was 1.5 (interquartile range 0.4–14.6) hours. Of all patients, 119 (58.9%) considered a TIA (or stroke) as the cause of their symptoms. Among them, 30 (25.2%) thought it was a medical emergency, while of the 83 not considering TIA as the cause of symptoms 38 (45.8%) thought of a medical emergency. Independently related to increased delay were (i) symptom onset out of hours, (ii) absence of dysarthria, (iii) being unaware that TIA requires urgent treatment, (iv) not considering the event an emergency, and (v) knowledge of TIA symptoms. Results for patients with a definite diagnosis of TIA/minor stroke were similar to those with alternative diagnoses. <b><i>Conclusion:</i></b> Patients still tend to wait till office hours to report TIA symptoms. Speech difficulties, and specifically dysarthria, are related to shorter delay. To reduce patient delay, awareness of TIA symptoms should increase and more importantly lay people should be educated to consider a TIA an emergency.
DOI: 10.6084/m9.figshare.8287898.v1
title: Dependence of cell doubling time on generation number for old pole and new pole daughter cells.

description: Old pole daughter cells took longer to divide than new pole daughter cells (our linear mixed model analysis returned χ2df=1 =5.192, p = 0.023). For both cell types, division time progressively increased over successive generations (our linear mixed model analysis returned χ2df=1 = 38.327, p &lt; 0.001). This analysis was carried out including data for generations 2 to 11 from two experimental runs.<br>
DOI: 10.6084/m9.figshare.8287823
title: One-way ANOVA behavioral data analysis: individual time-points

description: This data contains one-way ANOVA analyses performed on individual behavioral time-points.
DOI: 10.6084/m9.figshare.8287694
title: MS3_1_2.fq.gz

description: A part of transcriptome sequencing data of safflower flowers which were cultivated in different light intensities.<br>
DOI: 10.6084/m9.figshare.8287697
title: MS3_2_1.fq.gz

description: A part of transcriptome sequencing data of safflower flowers which were cultivated in different light intensities.
DOI: 10.6084/m9.figshare.8287700
title: MS3_2_2.fq.gz

description: A part of transcriptome sequencing data of safflower flowers which were cultivated in different light intensities.
DOI: 10.6084/m9.figshare.8287697.v1
title: MS3_2_1.fq.gz

description: A part of transcriptome sequencing data of safflower flowers which were cultivated in different light intensities.
DOI: 10.6084/m9.figshare.8287691
title: MS3_1_1.fq.gz

description: A part of transcriptome sequencing data of safflower flowers which were cultivated in different light intensities.
DOI: 10.6084/m9.figshare.8287694.v1
title: MS3_1_2.fq.gz

description: A part of transcriptome sequencing data of safflower flowers which were cultivated in different light intensities.<br>
DOI: 10.6084/m9.figshare.8287700.v1
title: MS3_2_2.fq.gz

description: A part of transcriptome sequencing data of safflower flowers which were cultivated in different light intensities.
DOI: 10.6084/m9.figshare.8287667
title: shuxia's data for submitted to share.xls

description: The data that support the findings of submission to European Journal of Soil Science (EJSS-336-18.R1).
DOI: 10.6084/m9.figshare.8287664
title: Population genetic polymorphism and mutation analysis of 19 autosomal STR loci in Jiangsu Han individuals in Eastern China

description: <b>Aim:</b> Genetic polymorphisms and the mutation ratio of 19 autosomal short tandem repeat (STR) loci were analysed in 10,000 individuals and 7755 families from Jiangsu Province in Eastern China. <b>Subjects and methods:</b> Nineteen STR loci were amplified by a multiplex amplification system and genotyped on the ABI 3130 Genetic Analyser. Allele frequencies, forensic parameters and mutations for the 19 autosomal STR loci were statistically analysed. <b>Results:</b> In total, 344 genotypes were discovered. No significant deviation from Hardy-Weinberg equilibrium was observed. The combined power of discrimination reached 0.9999999999999999984341, and the combined probability of paternity exclusion was 0.999999989. The pairwise genetic distance and <i>p</i>-values between the Jiangsu and 17 published populations depended on the F<sub>ST</sub> value calculation and are shown by the neighbour-joining evolutionary tree. No statistically significant differences were found, except for the Xinjiang Altay Han (<i>p</i> = 0.01802) population. The average mutation rate of the Jiangsu population across all 19 loci was 1.4 × 10<sup>−3</sup>. The average mutation rate of the 13 core CODIS STR loci remained below 2 × 10<sup>−3</sup> and there was no difference and relatively high consistency (<i>p</i> <b>Conclusions:</b> Allelic genetic polymorphisms and mutation data were obtained from a large number of samples, which indicated that the amplification kit is suitable for forensic application and that the Jiangsu population has its own genetic characteristics that are different from those of other ethnic populations.
DOI: 10.6084/m9.figshare.8287691.v2
title: MS3_1_1.fq.gz

description: A part of transcriptome sequencing data of safflower flowers which were cultivated in different light intensities.
DOI: 10.6084/m9.figshare.8287667.v1
title: shuxia's data for submitted to share.xls

description: The data that support the findings of submission to European Journal of Soil Science (EJSS-336-18.R1).
DOI: 10.6084/m9.figshare.8287691.v1
title: MS3_1_1.fq.gz

description: A part of transcriptome sequencing data of safflower flowers which were cultivated in different light intensities.