cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.28428941
title: Supplementary Material for: The Association Between Green Tea Consumption and Cognitive Function: A Meta-Analysis of Current Evidence

description: Background: Tea is widely consumed around the world, with green tea showing potential protective effects against cognitive decline, as indicated by multiple studies. These effects are thought to stem from its polyphenols and neuroprotective properties. This study aims to systematically review and meta-analyze recent observational research on the link between green tea consumption and the risk of cognitive impairment. Methods: A systematic search was performed in PubMed, Embase, Web of Science, and the Cochrane Library for observational studies published between September 2004 and September 2024. The relationship between green tea consumption and cognitive impairment was summarized using odds ratios with 95% confidence intervals. Additionally, the study conducted subgroup analyses, assessed heterogeneity, evaluated publication bias, and performed sensitivity analyses. Results: Eighteen studies were included, comprising a total of 58,929 participants. The quality of these studies was evaluated using the Newcastle-Ottawa Scale, and overall, the quality was found to be high. The random-effects meta-analysis indicated that green tea consumption was inversely associated with cognitive impairment OR 0.63 (95% CI: 0.54–0.73), with the greatest benefit observed in individuals aged 50–69 years. Subgroup analysis showed protective effects for dementia OR 0.75 (95% CI: 0.60–0.92) and mild cognitive impairment OR 0.64 (95% CI: 0.43–0.96). Additionally, a significant reduction in the risk of cognitive impairment was observed in Asian populations, whereas no such association was found in European populations. Both women OR 0.51 (95% CI: 0.28–0.95) and men OR 0.47 (95% CI: 0.28–0.80) showed significant associations. High consumption groups had reduced cognitive impairment risk OR 0.63 (95% CI: 0.50–0.82). Conclusions: Green tea consumption is associated with a reduced risk of cognitive impairment, suggesting potential cognitive benefits. However, large-scale longitudinal studies are needed to confirm dose-response relationships and long-term effects. Future studies should also investigate the long-term effects of green tea and its role in personalized nutrition based on genetic predispositions.
DOI: 10.6084/m9.figshare.28428947
title: Supplementary Material for: Clinical, genomic, and neurophysiological correlates of lifetime suicide attempts among individuals with an alcohol use disorder

description: Introduction: Research has identified multiple risk factors associated with suicide attempt (SA) among individuals with psychiatric illness. However, there is limited research among those with an alcohol use disorder (AUD), despite their disproportionately higher rates of SA. 
Methods: We examined lifetime suicide attempt in 4,068 individuals with an AUD from the Collaborative Study on the Genetics of Alcoholism (23% lifetime SA; 53% female; mean age: 38). We explored risk for lifetime SA across other clinical conditions ascertained from a clinical interview, polygenic scores (PGS) for comorbid psychiatric problems, and neurocognitive functioning. 
Results: Participants with an AUD who attempted suicide had greater rates of trauma exposure, major depressive disorder, post-traumatic stress disorder, other substance use disorders (SUD), and suicidal ideation. Polygenic scores for suicide attempt, depression, and PTSD were associated with increased odds of reporting a suicide attempt (ORs = 1.22 – 1.44). Participants who reported a SA also had decreased right hemispheric frontal-parietal theta and decreased interhemispheric temporal-parietal alpha electroencephalogram resting-state coherences relative to those who did not, but differences were small. 
Conclusions: Overall, individuals with an AUD who report lifetime SA experience greater levels of trauma, have more severe comorbidities, and carry increased polygenic risk for other psychiatric problems. Our results demonstrate the need to further investigate suicide attempts in the presence of SUDs.
DOI: 10.6084/m9.figshare.28428947.v1
title: Supplementary Material for: Clinical, genomic, and neurophysiological correlates of lifetime suicide attempts among individuals with an alcohol use disorder

description: Introduction: Research has identified multiple risk factors associated with suicide attempt (SA) among individuals with psychiatric illness. However, there is limited research among those with an alcohol use disorder (AUD), despite their disproportionately higher rates of SA. 
Methods: We examined lifetime suicide attempt in 4,068 individuals with an AUD from the Collaborative Study on the Genetics of Alcoholism (23% lifetime SA; 53% female; mean age: 38). We explored risk for lifetime SA across other clinical conditions ascertained from a clinical interview, polygenic scores (PGS) for comorbid psychiatric problems, and neurocognitive functioning. 
Results: Participants with an AUD who attempted suicide had greater rates of trauma exposure, major depressive disorder, post-traumatic stress disorder, other substance use disorders (SUD), and suicidal ideation. Polygenic scores for suicide attempt, depression, and PTSD were associated with increased odds of reporting a suicide attempt (ORs = 1.22 – 1.44). Participants who reported a SA also had decreased right hemispheric frontal-parietal theta and decreased interhemispheric temporal-parietal alpha electroencephalogram resting-state coherences relative to those who did not, but differences were small. 
Conclusions: Overall, individuals with an AUD who report lifetime SA experience greater levels of trauma, have more severe comorbidities, and carry increased polygenic risk for other psychiatric problems. Our results demonstrate the need to further investigate suicide attempts in the presence of SUDs.
DOI: 10.6084/m9.figshare.28428950
title: Supplementary Material for: A Case Report of Intravitreal Aflibercept for Iris Metastasis from Small Cell Lung Carcinoma with Neovascular Glaucoma

description: Abstract
Introduction
Metastatic iris tumors from lung cancer are uncommon and challenging to diagnose. As lung cancer treatments improve, life expectancy increases, potentially leading to more cases of metastasis. These tumors often cause neovascular glaucoma, making intraocular pressure (IOP) management crucial, especially in terminal-stage patients. 

Case Presentation
A 65-year-old man with small cell lung carcinoma (SCLC) presented with right ocular pain and blurred vision. His right IOP was 55 mmHg, and examination revealed anterior chamber cells, multiple greyish-white iris masses, and right iris neovascularization. Anterior chamber fluid cytology confirmed the diagnosis of metastatic iris tumors from SCLC. Despite treatment with topical eye drops, oral acetazolamide, and intravenous hypertonic mannitol, the IOP remained poorly controlled. Intravitreal aflibercept was subsequently administered into his right eye for neovascular glaucoma. Neovascular glaucoma disappeared rapidly, but IOP did not improve. However, intravenous infusion of hypertonic mannitol was no longer required, and the complaints of nausea associated with intraocular pressure decreased. Although this patient died four months after the initial visit due to multiple metastases of SCLC, the intravitreal aflibercept was effective in shrinking the iris tumor size and lowering intraocular pressure in the terminal phase of the disease. 

Conclusion
This is the first reported use of intravitreal aflibercept for SCLC metastases to the iris. While the prognosis of patients with metastatic iris tumors remains poor, intravitreal aflibercept injections show potential in reducing iris tumor size and lowering IOP. Although not curative, this therapeutic approach may play a significant role in the symptom management of these patients.
DOI: 10.6084/m9.figshare.28428953
title: Supplementary Material for: Deep learning and radiomics for gastric cancer lymph node metastasis: Automated segmentation and multi-machine learning study from two centers

description: Objective: The objective of this study is to develop an automated method for segmenting spleen computed tomography (CT) images using a deep learning model. This approach is intended to address the limitations of manual segmentation, which is known to be susceptible to inter-observer variability. Subsequently, a prediction model of gastric cancer (GC) lymph node metastasis was constructed in conjunction with radiomics and deep learning features, and a nomogram was generated to explore the clinical guiding significance.
Methods: This study enrolled 284 patients with pathologically confirmed GC from two centers. we employed a deep learning model, U-Mamba, to obtain fully automatic segmentation of the spleen CT images. Subsequently, radiomics features and deep learning features were extracted from the entire spleen CT images, and significant features were identified through dimensionality reduction. The clinical features, radiomic features, and deep learning features were organized and integrated, and five machine learning methods were employed to develop 15 predictive models. Ultimately, the model exhibiting superior performance was presented in the form of a nomogram. 
Results: A total of 12 radiomics features, 17 deep learning features, and 2 clinical features were deemed valuable. The DRC model demonstrated superior discriminative capacity relative to other models. A nomogram was constructed based on the logistic clinical model to facilitate the usage and verification of the clinical model.
Conclusion: Radiomics and deep learning features derived from automated spleen segmentation to construct a nomogram demonstrate efficacy in predicting LNM in GC. Concurrently, fully automated segmentation provides a novel and reproducible approach for radiomics research.
DOI: 10.6084/m9.figshare.28428956
title: Supplementary Material for: Choroidal Thickening and Outer Retinal Alterations in Vitamin A Deficiency – A Case Report

description: Purpose:
The purpose of this study was to report a case of retinal alterations due to proven Vitamin A deficiency.
Methods:
We report a case of a 39-year-old woman who presented with progressing nyctalopia and mildly reduced visual acuity over a period of 1-2 years, despite being on oral Vitamin A supplementation, following a history of gastric bypass and biliopancreatic diversion surgeries many years ago.
Results:
Vitamin A levels were severely reduced (&lt;0.1 µmol/L, reference range: 1.05–2.08 µmol/L). The outer retinal layers exhibited structural alterations and a reduction in thickness, while choroidal thickness was increased. The electroretinogram showed complete depletion of scotopic responses and a mild reduction in photopic responses. After intravenous Vitamin A supplementation, complete resolution of both functional and structural changes was achieved.
Conclusion:
This case highlights the importance of considering Vitamin A deficiency even in patients receiving ongoing oral Vitamin A supplementation, particularly if symptoms and clinical findings suggest its presence. Choroidal thickening and outer retinal thinning may provide further insights into the pathophysiology of this condition in future analyses.
DOI: 10.6084/m9.figshare.28428959.v1
title: Supplementary Material for: A case report: Metastatic Gestational Trophoblastic Neoplasia leading to acute respiratory failure and death. About a particularly challenging management in the intensive care unit, and exploring the potential of Pembrolizumab in treating frail pretreated Gestational Trophoblastic Neoplasia

description: Abstract:

Case presentation:

We present the case of a 37-year-old female patient who developed an acute respiratory failure requiring mechanical ventilation, two months after term delivery by cesarian section. The diagnosis of gestational trophoblastic neoplasia was suspected due to high level of HCG in post-partum period and thoracic imaging suggesting multiple pulmonary metastases. No biopsy was available. She subsequently developed severe ARDS requiring veno-venous extracorporeal membrane oxygenation (VV-ECMO) support alongside concurrent polychemotherapy. 
After spending 61 days in the intensive care unit (ICU), and achieving biological complete remission based on HCG monitoring, the patient was transferred to the oncology ward. Due to prolonged hypoperfusion and hypoxemia the patient developed ischemic cholangiopathy, severely constraining further therapeutic options. After 4 months of biological remission, the patient experienced a recurrence based on HCG rising and reappearing of pulmonary lesions on thoracic imaging in the lungs. 

In second-line, the patient was treated with carboplatin, with no significant response. In third-line, Pembrolizumab was used, and the patient experienced a significant decrease in HCG. However, due to hematologic toxicity, we discontinued the treatment. Subsequently, HCG level raised and the patient rapidly developed hemorrhagic cerebral metastasis and succumbed shortly thereafter.

Conclusion:

This case underscores the importance of prompt recognition and timely intervention in the management of patients with ARDS during the early postpartum period. GTN with lung involvement should be considered after excluding the other more frequent causes of ARDS. It also highlights how ECMO support enables the continuation of chemotherapy and the achievement of remission in choriocarcinoma. 
Furthermore, due to the inability to initiate the desired chemotherapy, immunotherapy was introduced as a possible treatment modality. Therefore, this case underscores the importance of adaptability in treatment plans based on patient-specific clinical conditions and collaborative decision-making with specialized centers. 
Finally, it emphasizes the efficacy of Pembrolizumab, even as a monotherapy, in pre-treated choriocarcinoma cases.
DOI: 10.6084/m9.figshare.28428962
title: Supplementary Material for: The contribution of phenomenology to the assessment of severe non-psychotic forms of psychopathological conditions in transitional age youth

description: Background: In recent times, adolescents with severe forms of psychopathology that do not unambiguously fit into a precise diagnostic category, have come to clinical observation. The diagnoses attributed to these young patients range from borderline personality disorder, to affective disorders, ADHD, and others. These diagnoses are mainly based on behavioural abnormalities (e.g., social withdrawal, aggressiveness, self-injuring behaviour), but fail to capture the experiential core of their suffering. Summary: Research in psychopathology, particularly that with a phenomenological approach, has long been committed to identifying early markers of schizophrenia in clinical pictures that precede the full onset of this pathology. In this paper, two case studies in Transitional Age Youth (TAY) and additional material taken from our own clinical practice are presented where self-disorders and anomalies of common sense - originally developed to phenomenologically characterise the schizophrenic spectrum phenotype, and especially non-delusional forms of schizophrenia - are used to complement standard nosographic assessments. Key-message: We propose that using some of these phenomenological constructs can shed light on certain TAY pictures, in particular the most serious ones, helping us to grasp their psychopathological core and provide further elements for a fine-grained characterization and in-depth understanding. We propose as a work-in-progress a set of tentative criteria to differentiate such phenomena in TAY patients as compared to patients with a diagnosis of schizophrenia.
DOI: 10.6084/m9.figshare.28428965
title: Supplementary Material for: Membranoproliferative glomerulonephritis with striated ultrastructural deposits with significantly elevated fibrinogen and fibronectin on mass spectrometry analysis: A case report and literature review

description: Glomerular diseases with organized deposits can be classified into various etiologies. A diagnostic algorithm based on clinical and pathological findings has been proposed. However, some cases cannot be diagnosed using existing algorithms. Here, we report the case of a 77-year-old man diagnosed with membranoproliferative glomerulonephritis (MPGN) with striated ultrastructural deposits, microfilament-like substructures with straight bands arranged in parallel in the subendothelial space by two sequential renal biopsies. His examinations and clinical findings were incompatible with known glomerular diseases with organized deposits. Dialysis was initiated 10 months after the second biopsy procedure. Furthermore, we report the first mass spectrometry analysis of laser micro-dissected glomeruli with striated ultrastructural deposits, which revealed significant levels of fibrinogen and fibronectin. Immunostaining was positive for fibrinogen, fibrin, and fibronectin in the subendothelial space. These findings suggest that the deposits were composed of a fibrin-fibronectin complex, and that accumulation of these fibrin-fibronectin complexes possibly induced endothelial injury, leading to MPGN. We also reviewed the literature on the clinical and pathological characteristics of the four cases with striated ultrastructural deposits. Our investigation showed that all patients had the MPGN pattern and striated ultrastructural deposits in the subendothelial space, and all underwent hemodialysis within 3 years after renal biopsy. Clinicians should be aware of the findings of glomerulonephritis with striated ultrastructural deposits since this disease may be a new entity and has a poor prognosis.
DOI: 10.6084/m9.figshare.28428968
title: Supplementary Material for: Synchronous double primary malignancy of non-small cell lung cancer and glioblastoma: A case report and literature review

description: Background: Non-small cell lung cancer (NSCLC) is the most common form of lung cancer and has a propensity to metastasize to the brain. It is incredibly difficult to distinguish between a primary brain lesions and a solitary metastasis from distant occult disease using current imaging techniques. Further, complications arise from the shifting paradigm in how medicine views NSCLC brain metastasis due to contemporary non-surgical curative treatments and the recent increase in the number of multiple primary malignancy (MPM) diagnoses associated with NSCLC. There is a dearth of reports regarding synchronous double primary malignancies involving separate lung and brain pathologies. Importantly, understanding the underlying cancer etiology is necessary for efficacious treatment strategy.
Case Presentation: A 65-year-old white male patient presented with node-positive NSCLC and a solitary intracranial lesion. The lung mass responded favorably to chemoradiotherapy while the brain lesion continued to progress despite stereotactic radiosurgery treatment. Subsequent resection of the brain lesion, conducted eight months after initial presentation, surprisingly revealed a second primary cancer diagnosis of glioblastoma (GB). Unfortunately, despite revision of systemic therapeutic strategy, the patient continued to progress through treatment and ultimately died 16 months after the initial diagnosis.
Conclusions: Herein is the third report regarding synchronous double primary malignancies involving non-small cell lung cancer NSCLC and GB. This report of an assumed metastatic NSCLC patient with a solitary brain lesion, history of smoking, and COPD underscores the need for pathological confirmation of all new presentations of metastatic disease via biopsy and highlights the importance of including the possibility of a second primary in the differential diagnosis. Additional reports of NSCLC and synchronous solitary brain lesions are needed to further elucidate pertinent patient characteristics and better inform clinical decision making.
DOI: 10.15468/dl.ezvwdh
title: Occurrence Download

description: A dataset containing 139 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Proceratophrys concavitympanum Giaretta, Bernarde & Kokubum, 2000"
 ]
}

 The dataset includes 139 records from 8 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0002767-250214102907787/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.6084/m9.figshare.28428971
title: Supplementary Material for: Questionnaire Survey on the Diagnosis and Treatments of Eosinophilic Gastrointestinal Diseases (EGID) in Asia

description: Introduction: Eosinophilic gastrointestinal disease (EGID) is divided into eosinophilic esophagitis (EoE) and non-eosinophilic esophagitis eosinophilic gastrointestinal disease (non-EoE-EGID), based on the involved gastrointestinal organs. The present survey was performed to provide an overview of the current status of the epidemiology, diagnosis, and treatment of EGID in Asia. Methods: Responses to the questionnaire were obtained from 228 doctors at various institutions in eight Asian countries. The questionnaire consisted of 52 questions on EoE and non-EoE EGID. Results: Responses to Questionnaire were obtained from 228 doctors from eight countries. The most common participation facilities were university hospitals, followed by public hospitals, private hospitals, and private clinics. 1-10 were the most frequent patients per year in each institution for both EoE and non-EoE-EGIDs. 30’s and 40’s are common age groups for both EoE and non-EoE-EGID. Although endoscopic findings vary among countries, 15 or more eosinophil infiltrations in high-power fields as a diagnostic criterion are used in all countries for EoE. As treatments, the prescription rates of Proton pump inhibitor (PPI), diet, topical and systemic steroids, and biologics were similar among the eight countries in EoE. Non-EoE-EGID showed a similar trend to EoE in epidemiology, symptoms, diagnosis, and treatment. Conclusion: The questionnaire survey partially revealed the current status of the epidemiology, symptoms, diagnosis, and treatment of EGID in Asian countries.
DOI: 10.6084/m9.figshare.28428974
title: Supplementary Material for: Validation of an Arabic questionnaire to assess pediatric behavioral feeding disorders

description: Introduction:
Behavioral feeding assessment allows for identifying the nature and the cause of abnormal feeding behaviors during mealtime, making prognostic predictions, and creating effective treatment plans. This study aimed to develop and validate an Arabic questionnaire to assess abnormal feeding behaviors among Arabic-speaking children.
Methods:
Mansoura Pediatric Eating Assessment Scale (MPEAS) was developed and administered to the parents of 100 Arabic-speaking children aged 1-5, including 50 typically developing children without feeding problems and 50 children with abnormal feeding behaviors. The scale includes 40 items in four subdomains (feeding skills, mealtime circumstances, child behavior, and parent behavior). Scoring was based on a 4-point Likert scale, with lower scores indicating greater impairment. Standardized procedures were used to develop and validate the MPEAS, including the items generation phase, pilot study, validation, and reliability testing. 
Results:
MPEAS demonstrated excellent validity (face, content, discriminant, predictive, and convergent) and reliability. 
Conclusion:
MPEAS is a valid, reliable, and easily applicable tool for assessing behavioral feeding problems in Arabic-speaking children. This sensitive and specific tool has the potential to significantly improve the screening and treatment of behavioral feeding problems among Arabic-speaking children, offering hope for better outcomes.