cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.5260411.v1
title: Petrogenesis and tectonic implications of early Palaeozoic igneous rocks of the western South Qilian Belt, central China

description: Early Palaeozoic granitoids in the South Qilian Belt, central China, record details of the tectonic evolution and crustal growth of the Qilian orogenic belt. Five representative granitoids from the western South Qilian Belt were sampled for zircon LA-ICPMS U–Pb dating, Lu–Hf isotopes, and whole-rock geochemical analyses. Zircon U–Pb dating of two porphyritic granodiorites and a porphyritic monzogranite yielded ages of 442.7 ± 3.5, 441.8 ± 4.3, and 435.4 ± 3.5 Ma, respectively. These granitoids exhibit a geochemical affinity to I-type granite, are metaluminous with a low aluminium saturation index (A/CNK = 0.75–1.15), have moderate Al<sub>2</sub>O<sub>3</sub> and low MgO contents, high La/Yb and low Sr/Y ratios, and are depleted in Nb, Ta, P, and Ti, which suggests a subduction zone magmatic arc affinity, with mixing between a primary mantle-derived magma with lesser continental crustal material. The syenogranite and monzogranite from the South Qilian Belt, which yield U–Pb zircon ages of 440.4 ± 9.0 and 442.3 ± 1.2 Ma, respectively, have pronounced S-type geochemical affinities, are peraluminous with A/CNK values of 1.07–1.16, have relatively high SiO<sub>2</sub>, Al<sub>2</sub>O<sub>3</sub>, K<sub>2</sub>O, and Rb contents, low Y and Yb, low Sr/Y and La/Yb ratios, positive Th, U, and light Rare Earth Element (REE) anomalies, and depletions in Nb, Ta, Sr, and Ti. Their geochemical signature suggests derivation from partial melting of continental crust in a syn-collisional setting. The Hf isotopic data of zircons from the granitoids show a significant input of Paleoproterozoic crust in the crustal formation of the western South Qilian Belt in Palaeozoic. Compare the <i>ε</i><sub>Hf</sub>(<i>t</i>) value of S-type granite with that of I-type granite, the former may have a comparatively homogeneous source. Together with regional evidence, it is proposed that a collisional event occurred between the South Qilian Belt and the Central Qilian Belt at ca. 442–435 Ma.
DOI: 10.6084/m9.figshare.25467538
title: Heterodyning, Dataset 2

description: Dataset 2
DOI: 10.6084/m9.figshare.25467538.v1
title: Heterodyning, Dataset 2

description: Dataset 2
DOI: 10.6084/m9.figshare.5267800
title: Fossil fruits of <i>Canarium</i> (Burseraceae) from Eastern Asia and their implications for phytogeographical history

description: The genus <i>Canarium</i> contains approximately 78 species distributed in the Old World tropics and subtropics. <i>Canarium</i> is characterized by a distinctive drupaceous fruit with a trilocular endocarp derived from three fused pyrenes. Here, we describe new <i>Canarium</i> fossil fruits from the late Oligocene of the Yongning Formation, the Miocene of the Erzitang Formation, and the late Miocene of the Foluo Formation in Guangxi Province, South China, providing the first confirmed fossil occurrences of <i>Canarium</i> in eastern Asia. The fruits of <i>Canarium guangxiensis</i> Han & Manchester sp. nov. are ovoidal to spindle shaped, 22.8–34.3 mm long, and 10.7–14.6 mm wide. Computed tomography (CT) scan was used to study the morphological and anatomical characters of fossil and modern <i>Canarium</i>, facilitating identification of the fossil fruits. This new occurrence supplements other megafossil records of <i>Canarium</i> fruits from the Eocene in North America, the Eocene to Oligocene in Europe, the Oligocene in Africa, the Oligocene to Miocene in Asia and from the Pleistocene in Australia and the Pacific islands. The fossil record indicates a wide dispersal of <i>Canarium</i> over the Northern Hemisphere during the Eocene and Oligocene, followed by a geographical contraction during the Miocene as the result of its extinction from North America and Europe. The origin and migratory routes of this genus are not clearly resolved, but based on the fossils known so far, we hypothesize that <i>Canarium</i> may have had a North American Eocene origin, with subsequent spread to Eurasia and Africa, followed by dispersal to the Southern Hemisphere.
DOI: 10.6084/m9.figshare.5267986
title: Suijing18 short-read sequencing data based on Illumina 200bp library

description: The 200bp- libraries with peak insert size at at ~200 bp was prepared using aan Illumina Truseq DNA library protocol (Illumina Kit FC-121-4001; Illumina Inc., San Diego, CA, USA). The qualities of libraries were checked by using the a standard protocol involved in Agilent 2100 Bioanalyzer High Sensitivity Kit. After library profile analysis, the library was sequenced with by using pair-end 150 bp pair-end strategies on with the Illumina HiSeq X10 platform (Illumina Inc.). This is the 23.6Gb data from 200bp library with coverage of 59X for Suijing 18.
DOI: 10.6084/m9.figshare.5267986.v1
title: Suijing18 short-read sequencing data based on Illumina 200bp library

description: The 200bp- libraries with peak insert size at at ~200 bp was prepared using aan Illumina Truseq DNA library protocol (Illumina Kit FC-121-4001; Illumina Inc., San Diego, CA, USA). The qualities of libraries were checked by using the a standard protocol involved in Agilent 2100 Bioanalyzer High Sensitivity Kit. After library profile analysis, the library was sequenced with by using pair-end 150 bp pair-end strategies on with the Illumina HiSeq X10 platform (Illumina Inc.). This is the 23.6Gb data from 200bp library with coverage of 59X for Suijing 18.
DOI: 10.6084/m9.figshare.5267992
title: Suijing18 long-read sequencing data based on PacBio SMART

description: The Sequel 20K libraries were prepared with the standard protocol from PacBio and sequenced with the PacBio LRS instrument, model Sequel. We finally generated 25 Gb of long-read sequencing (LRS) raw data with sequencing depthcoverage of 62X for Suijing 18.
DOI: 10.6084/m9.figshare.5267992.v1
title: Suijing18 long-read sequencing data based on PacBio SMART

description: The Sequel 20K libraries were prepared with the standard protocol from PacBio and sequenced with the PacBio LRS instrument, model Sequel. We finally generated 25 Gb of long-read sequencing (LRS) raw data with sequencing depthcoverage of 62X for Suijing 18.
DOI: 10.6084/m9.figshare.5276758.v1
title: One-way ANOVA within-subjects

description: An fMRI group data set (One-way ANOVA) used in "Neural encoding of saltatory pneumotactile velocity in human glabrous hand"
DOI: 10.6084/m9.figshare.5276761.v1
title: One sample t-test. (5cm/s &gt; No stimulus)

description: One sample t-test revealed a significant BOLD response of one-sided individual velocities compared to all TAC-Cells off (no stimulus).
DOI: 10.6084/m9.figshare.5276761.v2
title: One sample t-test. (5cm/s &gt; No stimulus)

description: An fMRI group data set (one sample t-test. 5cm/s &gt; No stimulus) used in "Neural encoding of saltatory pneumotactile velocity in human glabrous hand"
DOI: 10.6084/m9.figshare.5276794.v1
title: One sample t-test. (25cm/s &gt; No stimulus)

description: An fMRI group data set (one sample t-test. 25cm/s &gt; No stimulus) used in "Neural encoding of saltatory pneumotactile velocity in human glabrous hand"
DOI: 10.6084/m9.figshare.5276800.v1
title: One sample t-test. (65cm/s &gt; No stimulus)

description: An fMRI group data set (one sample t-test. 65cm/s &gt; No stimulus) used in "Neural encoding of saltatory pneumotactile velocity in human glabrous hand"
DOI: 10.6084/m9.figshare.5276803.v1
title: One sample t-test. (5cm/s &gt; All ON)

description: An fMRI group data set (one sample t-test. 5cm/s &gt; All ON) used in "Neural encoding of saltatory pneumotactile velocity in human glabrous hand"
DOI: 10.6084/m9.figshare.5276806.v1
title: One sample t-test. (25cm/s &gt; All on)

description: An fMRI group data set (one sample t-test. 25cm/s &gt; All ON) used in "Neural encoding of saltatory pneumotactile velocity in human glabrous hand"
DOI: 10.6084/m9.figshare.5276812.v1
title: One sample t-test. (65cm/s &gt; All on)

description: An fMRI group data set (one sample t-test. 65cm/s &gt; All ON) used in "Neural encoding of saltatory pneumotactile velocity in human glabrous hand"
DOI: 10.6084/m9.figshare.5276992
title: Neural encoding of saltatory pneumotactile velocity in human glabrous hand

description: An fMRI Data set used in "Neural encoding saltatory pneumotactile velocity in human glabrous hand".
DOI: 10.6084/m9.figshare.25467727
title: Supplementary Data

description: Genomic alterations in chemotherapy genes detected in three model Thai adolescent patients with fatal osteosarcoma at Maharaj Nakorn Chiang Mai Hospital, Thailand.OBJECTIVE: Osteosarcoma is the most common primary bone malignancy among adolescents and young adults, characterized by a high mortality rate, though it remains a relatively rare disease overall. The treatment protocols can be complex and challenging. We conducted a comparative genomic variation study to identify genes involved in the metabolism of chemotherapy drugs that are affected by various genomic alterations.METHODS: This study investigated the germline and tumor genomes of three primary osteosarcoma patients who responded poorly to chemotherapy, later developed lung metastases, and ultimately succumbed to the disease. Whole Genome Sequencing (WGS) data for both the germline and tumor genomes of these patients were analyzed to identify deleterious single nucleotide polymorphisms (SNPs), copy number variations (CNVs), and structural variations (SVs) in genes associated with chemotherapy and cancer. An in silico analysis of protein association networks was performed on the affected genes of each patient to identify both common and unique biological processes associated with osteosarcoma.RESULTS: All patients shared a stop-gained mutation in the tumor suppressor gene MLH1 and a frameshift mutation in REV3L, present in both their germline and tumor genomes. Additionally, a high-impact variant in a splice donor site of the tumor suppressor gene TP53 was found in their tumor genomes. The tumor genome of patient OS0059 was extensively affected by CNVs, whereas the tumor genomes of patients OS0061 and OS0081 demonstrated relatively moderate CNVS. Structural variations were detected in all three tumor genomes and affect different key genes involved in platinum drug resistance and DNA repair. All identified mutated genes were also correlated with the clinical features of the patients.CONCLUSIONS: The genetic makeup of osteosarcoma is complex and varies from patient to patient, potentially affecting processes related to cell death or resistance to chemotherapy. Our investigations suggest that structural alterations, such as copy number variations (CNVs) and structural variations (SVs), in genes involved in chemotherapy metabolism and DNA repair mechanisms in tumor biopsies, could be useful for clinicians to design chemotherapy regimens suitable for different osteosarcoma (OS) patients.
DOI: 10.6084/m9.figshare.25467727.v1
title: Supplementary Data

description: Genomic alterations in chemotherapy genes detected in three model Thai adolescent patients with fatal osteosarcoma at Maharaj Nakorn Chiang Mai Hospital, Thailand.OBJECTIVE: Osteosarcoma is the most common primary bone malignancy among adolescents and young adults, characterized by a high mortality rate, though it remains a relatively rare disease overall. The treatment protocols can be complex and challenging. We conducted a comparative genomic variation study to identify genes involved in the metabolism of chemotherapy drugs that are affected by various genomic alterations.METHODS: This study investigated the germline and tumor genomes of three primary osteosarcoma patients who responded poorly to chemotherapy, later developed lung metastases, and ultimately succumbed to the disease. Whole Genome Sequencing (WGS) data for both the germline and tumor genomes of these patients were analyzed to identify deleterious single nucleotide polymorphisms (SNPs), copy number variations (CNVs), and structural variations (SVs) in genes associated with chemotherapy and cancer. An in silico analysis of protein association networks was performed on the affected genes of each patient to identify both common and unique biological processes associated with osteosarcoma.RESULTS: All patients shared a stop-gained mutation in the tumor suppressor gene MLH1 and a frameshift mutation in REV3L, present in both their germline and tumor genomes. Additionally, a high-impact variant in a splice donor site of the tumor suppressor gene TP53 was found in their tumor genomes. The tumor genome of patient OS0059 was extensively affected by CNVs, whereas the tumor genomes of patients OS0061 and OS0081 demonstrated relatively moderate CNVS. Structural variations were detected in all three tumor genomes and affect different key genes involved in platinum drug resistance and DNA repair. All identified mutated genes were also correlated with the clinical features of the patients.CONCLUSIONS: The genetic makeup of osteosarcoma is complex and varies from patient to patient, potentially affecting processes related to cell death or resistance to chemotherapy. Our investigations suggest that structural alterations, such as copy number variations (CNVs) and structural variations (SVs), in genes involved in chemotherapy metabolism and DNA repair mechanisms in tumor biopsies, could be useful for clinicians to design chemotherapy regimens suitable for different osteosarcoma (OS) patients.
DOI: 10.6084/m9.figshare.5281213
title: A new antiarch placoderm from the Emsian (Early Devonian) of Wuding, Yunnan, China

description: Pan, Z., Zhu, M., Zhu, Y. & Jia, L., August 2017. A new antiarch placoderm from the Emsian (Early Devonian) of Wuding, Yunnan, China. <i>Alcheringa 42</i>, 10–21. ISSN 0311-5518. <i>Wufengshania magniforaminis</i>, a new genus and species of the Euantiarcha (Placodermi: Antiarcha), is described from the late Emsian (Early Devonian) of Wuding, Yunnan, southwestern China. The referred specimens were three-dimensionally preserved in black shales, allowing a high-resolution computed tomography reconstruction of anatomical details. The new euantiarch is characterized by a large orbital fenestra, an arched exoskeletal band around the orbital fenestra and a developed obtected nuchal area of the skull roof. Maximum parsimony analysis, using a revised data-set of antiarchs with 44 taxa and 66 characters, resolves <i>Wufengshania</i> gen. nov. as a member of the Bothriolepididae, which is characterized by the presence of the infraorbital sensory canal diverging on the lateral plate, and the nuchal plate with orbital facets. New analysis supports a sister group relationship between <i>Dianolepis</i> and the Bothriolepididae. <i>Luquanolepis</i>, a coeval euantiarch from the neighboring site of the new form, is referred to the Asterolepidoidei and represents the basalmost and earliest member of the Asterolepidoidei. <i>Zhaohui Pan* [</i>panzhaohui@ivpp.ac.cn<i>], Min Zhu* [</i>zhumin@ivpp.ac.cn<i>], You’an Zhu</i><sup><i>†</i></sup><i>[</i>zhuyouan@ivpp.ac.cn<i>]</i> and <i>Liantao Jia [</i>jialiantao@ivpp.ac.cn<i>] Key Laboratory of Vertebrate Evolution and Human Origins of Chinese Academy of Sciences, Institute of Vertebrate Paleontology and Paleoanthropology, Chinese Academy of Sciences, PO Box 643, Beijing 100044, PR China. *Also affiliated with University of Chinese Academy of Sciences, Beijing, 100049, PR China.</i> <sup><i>†</i></sup><i>Also affiliated with Uppsala University, PO Box 256, 751 05 Uppsala, Sweden.</i>
DOI: 10.6084/m9.figshare.5281213.v1
title: A new antiarch placoderm from the Emsian (Early Devonian) of Wuding, Yunnan, China

description: Pan, Z., Zhu, M., Zhu, Y. & Jia, L., August 2017. A new antiarch placoderm from the Emsian (Early Devonian) of Wuding, Yunnan, China. <i>Alcheringa 42</i>, 10–21. ISSN 0311-5518. <i>Wufengshania magniforaminis</i>, a new genus and species of the Euantiarcha (Placodermi: Antiarcha), is described from the late Emsian (Early Devonian) of Wuding, Yunnan, southwestern China. The referred specimens were three-dimensionally preserved in black shales, allowing a high-resolution computed tomography reconstruction of anatomical details. The new euantiarch is characterized by a large orbital fenestra, an arched exoskeletal band around the orbital fenestra and a developed obtected nuchal area of the skull roof. Maximum parsimony analysis, using a revised data-set of antiarchs with 44 taxa and 66 characters, resolves <i>Wufengshania</i> gen. nov. as a member of the Bothriolepididae, which is characterized by the presence of the infraorbital sensory canal diverging on the lateral plate, and the nuchal plate with orbital facets. New analysis supports a sister group relationship between <i>Dianolepis</i> and the Bothriolepididae. <i>Luquanolepis</i>, a coeval euantiarch from the neighboring site of the new form, is referred to the Asterolepidoidei and represents the basalmost and earliest member of the Asterolepidoidei. <i>Zhaohui Pan* [</i>panzhaohui@ivpp.ac.cn<i>], Min Zhu* [</i>zhumin@ivpp.ac.cn<i>], You’an Zhu</i><sup><i>†</i></sup><i>[</i>zhuyouan@ivpp.ac.cn<i>]</i> and <i>Liantao Jia [</i>jialiantao@ivpp.ac.cn<i>] Key Laboratory of Vertebrate Evolution and Human Origins of Chinese Academy of Sciences, Institute of Vertebrate Paleontology and Paleoanthropology, Chinese Academy of Sciences, PO Box 643, Beijing 100044, PR China. *Also affiliated with University of Chinese Academy of Sciences, Beijing, 100049, PR China.</i> <sup><i>†</i></sup><i>Also affiliated with Uppsala University, PO Box 256, 751 05 Uppsala, Sweden.</i>
DOI: 10.6084/m9.figshare.5285134
title: Raw data: Mercury leaching ratio (μg/g) from Tibetan medicine Zuotai,β-HgS and α-HgS in pure water and artificial gastrointestinal juices containing Cys(or GSH) or not.

description: <i>Zuotai</i>, a known Tibetan
medicinal mixture containing insoluble cubic mercuric sulfide (β-HgS), has been
used to treat diseases with long history. The mercury leaching ratio from <i>Zuotai </i>in
gastrointestinal environment is one determinant factor for its bioavailability
and biological effect. However, the information is still scarce now. Therefore,
the study was designed to investigate the effect of sulfhydryl biomolecules
[L-cysteine (Cys) and glutathione (GSH)] on mercury leaching from <i>Zuotai</i>,
β-HgS, and α-HgS in artificial gastrointestinal juices or pure water.

The artificial gastric juice and artificial intestinal juice were prepared
according to the methods described in <i>Chinese Pharmacopoeia </i>(2010
version). The following solutions were prepared: Cys in pure water (5.21
g/L), GSH in pure water (13.21 g/L), Cys in artificial gastric juice (5.21
g/L), GSH in artificial gastric juice (13.21 g/L), Cys in artificial intestinal
juice (5.21 g/L), and GSH in artificial intestinal juice (13.21 g/L). The moles
of Cys and GSH in this study were 0.215 mmol—the same as that of β-HgS and
α-HgS. A solid-liquid ratio of 1:100 was adopted in all leaching experiments.
Digestion, peristalsis and emptying of drug in the gastrointestinal tract were
simulated <i>in vitro</i>. We detected the mercury released in solutions
using Automatic Direct Mercury Analyzer. Leaching Ratio of Mercury
(μg/g)=[Total Weight of Mercury Released (μg)]/[Total Weight of Substance
Tested (g)]

The results showed the following trend for
the mercury leaching ratio of<i> Zuotai</i>: artificial gastric juice &gt;
artificial intestinal juice &gt; pure water, whereas the trend for β-HgS and
α-HgS was as follows: artificial intestinal fluid &gt; artificial gastric fluid
&gt; pure water. The mercury leaching ratios of <i>Zuota</i>i, β-HgS, and
α-HgS significantly increased in artificial intestinal juice containing L-Cys
or GSH compared to that without sulfhydryl biomolecules in the juice. However,
in pure water and artificial gastric juice with Cys or GSH, the mercury
leaching ratio of <i>Zuotai </i>reduced remarkably, in contrast to
the results observed for β-HgS and α-HgS.
DOI: 10.6084/m9.figshare.5285134.v2
title: Raw data: Mercury leaching ratios(μg/g) from Tibetan medicine Zuotai,β-HgS and α-HgS in pure water and artificial gastrointestinal juices containing Cys(or GSH) or not.

description: <i>Zuotai</i>, a known Tibetan
medicinal mixture containing insoluble cubic mercuric sulfide (β-HgS), has been
used to treat diseases with long history. The mercury leaching ratio from <i>Zuotai </i>in
gastrointestinal environment is one determinant factor for its bioavailability
and biological effect. However, the information is still scarce now. Therefore,
the study was designed to investigate the effect of sulfhydryl biomolecules
[L-cysteine (Cys) and glutathione (GSH)] on mercury leaching from <i>Zuotai</i>,
β-HgS, and α-HgS in artificial gastrointestinal juices or pure water.

The artificial gastric juice and artificial intestinal juice were prepared
according to the methods described in <i>Chinese Pharmacopoeia </i>(2010
version). The following solutions were prepared: Cys in pure water (5.21
g/L), GSH in pure water (13.21 g/L), Cys in artificial gastric juice (5.21
g/L), GSH in artificial gastric juice (13.21 g/L), Cys in artificial intestinal
juice (5.21 g/L), and GSH in artificial intestinal juice (13.21 g/L). The moles
of Cys and GSH in this study were 0.215 mmol—the same as that of β-HgS and
α-HgS. A solid-liquid ratio of 1:100 was adopted in all leaching experiments.
Digestion, peristalsis and emptying of drug in the gastrointestinal tract were
simulated <i>in vitro</i>. We detected the mercury released in solutions
using Automatic Direct Mercury Analyzer. Leaching Ratio of Mercury
(μg/g)=[Total Weight of Mercury Released (μg)]/[Total Weight of Substance
Tested (g)]

The results showed the following trend for
the mercury leaching ratio of<i> Zuotai</i>: artificial gastric juice &gt;
artificial intestinal juice &gt; pure water, whereas the trend for β-HgS and
α-HgS was as follows: artificial intestinal fluid &gt; artificial gastric fluid
&gt; pure water. The mercury leaching ratios of <i>Zuota</i>i, β-HgS, and
α-HgS significantly increased in artificial intestinal juice containing L-Cys
or GSH compared to that without sulfhydryl biomolecules in the juice. However,
in pure water and artificial gastric juice with Cys or GSH, the mercury
leaching ratio of <i>Zuotai </i>reduced remarkably, in contrast to
the results observed for β-HgS and α-HgS.