cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.3452765.v1
title: Supplementary Material for: Swiss S1 Guidelines on the Systemic Treatment of Psoriasis Vulgaris

description: Psoriasis vulgaris is a common, chronic inflammatory skin disease with a prevalence of 1.5-2% in Western industrialized countries. A relevant percentage of patients suffer from moderate-to-severe psoriasis and experience a significant reduction in quality of life. The choice of an adequate therapy could help to prevent disease and exacerbation of comorbidity, which could increase quality of life, avoid hospitalization and avoid reduction of working days. The present guidelines are focused on the initiation and management of systemic therapies in cases of moderate-to-severe plaque-type psoriasis in adults to optimize treatment response, adherence and quality of life. This first version of the Swiss S1 guidelines presents therapeutic recommendations which are based on a systematic literature search as well as an informal expert consensus of dermatologists in Switzerland.
DOI: 10.17633/rd.brunel.3452762
title: Usher syndrome study.sav

description: The aim of this study was to determine if psychosocial wellbeing predicts the health-related quality of life (HRQOL) of people with Usher syndrome. Ninety UK-resident adults with Usher syndrome were recruited through deafblind-related charities, support groups and social groups. All participants took part in a survey that measured their physical and mental HRQOL, depressive symptoms, loneliness and social support. Measured confounders included age, sex and health-related characteristics. Hierarchical multiple linear regression analyses examined the association of each psychosocial wellbeing indicator with both physical and mental HRQOL while controlling for confounders in a stepwise manner.
DOI: 10.6084/m9.figshare.3452759
title: The Dreariness of a Desolate Life

description: Dr. Kajal Srivastava completed her Ph.D (English) from Bundelkhand University, Jhansi. She is currently a faculty of Business Communication at Jaipuria Institue Of Management, Lucknow Campus (India). Her interest lies in the field of Communication, Literature and Writing Poetry. Her body of work includes; [i] “Without You,” International Journal Of English: Literature, Language & Skills ISSN 2278 0742 Volume 5, Issue: Special Issue 1, Pages 20, Publisher: IJELLS [ii] “The Life Of A Common Man On The Beaten Track,” Journal: Research Scholar An International Refereed e-Journal of Literary Explorations ISSN 2320 – 6101, Volume 4, Issue I, Pages 414, Publisher:Research Scholar, [iii] “Journey of Life,”Journal: International Journal of English: Literature, Language and Skills(IJELLS), ISSN 2278 0742, Volume3, Issue IV, Pages10, Publisher: International Journal of English: Literature, Language and Skills(IJELLS), [iv] “A Lone Desert” Journal: Research Scholar An International Refereed e-Journal of Literary Explorations ISSN 2320 – 6101, Volume 2, Issue III Pages 893, Publisher: Research Scholar [v] “Let Me Be” Journal: Journal of ELT and Poetry ISSN 2347-887X, Volume 2, Issue: Issue 3, Pages 305, Publisher: Journal of ELT and Poetry
DOI: 10.6084/m9.figshare.3452759.v2
title: The Dreariness of a Desolate Life

description: Dr. Kajal Srivastava completed her Ph.D (English) from Bundelkhand University, Jhansi. She is currently a faculty of Business Communication at Jaipuria Institue Of Management, Lucknow Campus (India). Her interest lies in the field of Communication, Literature and Writing Poetry. Her body of work includes; [i] “Without You,” International Journal Of English: Literature, Language & Skills ISSN 2278 0742 Volume 5, Issue: Special Issue 1, Pages 20, Publisher: IJELLS [ii] “The Life Of A Common Man On The Beaten Track,” Journal: Research Scholar An International Refereed e-Journal of Literary Explorations ISSN 2320 – 6101, Volume 4, Issue I, Pages 414, Publisher:Research Scholar, [iii] “Journey of Life,”Journal: International Journal of English: Literature, Language and Skills(IJELLS), ISSN 2278 0742, Volume3, Issue IV, Pages10, Publisher: International Journal of English: Literature, Language and Skills(IJELLS), [iv] “A Lone Desert” Journal: Research Scholar An International Refereed e-Journal of Literary Explorations ISSN 2320 – 6101, Volume 2, Issue III Pages 893, Publisher: Research Scholar [v] “Let Me Be” Journal: Journal of ELT and Poetry ISSN 2347-887X, Volume 2, Issue: Issue 3, Pages 305, Publisher: Journal of ELT and Poetry
DOI: 10.6084/m9.figshare.3452753
title: Supplementary Material for: A Systematic Review and Meta-Analysis of Studies Examining the Use of Brain Laser Interstitial Thermal Therapy versus Craniotomy for the Treatment of High-Grade Tumors in or near Areas of Eloquence: An Examination of the Extent of Resection and Major Complication Rates Associated with Each Type of Surgery

description: <b><i>Background:</i></b> The extent of resection (EOR) of high-grade gliomas (WHO grade III or IV) in or near areas of eloquence is associated with overall patient survival, but with higher major neurocognitive complications. <b><i>Methods:</i></b> A systematic review and meta-analysis was undertaken of the peer-reviewed literature in order to identify studies which examined EOR or extent of ablation (EOA) and major complications (defined as neurocognitive or functional complications which last &gt;3 months duration after surgery) associated with either brain laser interstitial thermal therapy (LITT) or open craniotomy in high-grade tumors in or near areas of eloquence. <b><i>Results:</i></b> Eight studies on brain LITT (n = 79 patients) and 12 craniotomy studies (n = 1,036 patients) were identified which examined either/both EOR/EOA and complications. Meta-analysis demonstrated an EOA/EOR of 85.4 ± 10.6% with brain LITT versus 77.0 ± 40% with craniotomy (mean difference: 8%; 95% CI: 2-15; p = 0.01; inverse variance, random effects model). Meta-analysis of proportions of major complications for each individual therapy demonstrated major complications of 5.7% (95% CI: 1.8-11.6) and 13.8% (95% CI: 10.3-17.9) for LITT and craniotomy, respectively. <b><i>Conclusion:</i></b> In patients presenting with high-grade gliomas in or near areas of eloquence, early results demonstrate that brain LITT may be a viable surgical alternative.
DOI: 10.6084/m9.figshare.3452711
title: Supplementary Material for: Mutant p53 Gain of Function and Chemoresistance: The Role of Mutant p53 in Response to Clinical Chemotherapy

description: <b><i>Purpose:</i></b> To review mechanisms underlying mutant p53 (mutp53) gain of function (GOF) and mutp53-induced chemoresistance, and to investigate the role of mutp53 in response to clinical chemotherapy. <b><i>Methods:</i></b> We searched the PubMed database for clinical studies from the past decade, including data evaluating the impact of mutp53 in clinical chemotherapy response. <b><i>Results:</i></b> Interactions between mutp53 and transcriptional factors, proteins or DNA structures, as well as epigenetic regulation, contribute to mutp53 GOF. Major mechanisms of mutp53-induced chemoresistance include enhanced drug efflux and metabolism, promoting survival, inhibiting apoptosis, upregulating DNA repair, suppressing autophagy, elevating microenvironmental resistance and inducing a stem-like phenotype. Clinically, mutp53 predicted resistance to chemotherapy in diffuse large B-cell lymphoma, and esophageal and oropharyngeal cancers, but its impact on chronic lymphocytic leukemia was unclear. In bladder cancer, mutp53 did not predict resistance, whereas in some breast and ovarian cancers, it was associated with sensitivity to certain chemotherapeutic agents. <b><i>Conclusion:</i></b> mutp53 has an intricate role in the response to clinical chemotherapy and should not be interpreted in isolation. Furthermore, when predicting tumor response to chemotherapy based on the p53 status, the drugs used should also be taken into consideration. These concepts require further investigation.
DOI: 10.6084/m9.figshare.3452639
title: Supplementary Material for: Characterization of Integrons and Sulfonamide Resistance Genes among Bacteria from Drinking Water Distribution Systems in Southwestern Nigeria

description: <b><i>Background:</i></b> The emergence of antibiotic resistance among pathogenic bacteria in clinical and environmental settings is a global problem. Many antibiotic resistance genes are located on mobile genetic elements such as plasmids and integrons, enabling their transfer among a variety of bacterial species. Water distribution systems may be reservoirs for the spread of antibiotic resistance. <b><i>Materials and Methods:</i></b> Bacteria isolated from raw, treated, and municipal tap water samples from selected water distribution systems in south-western Nigeria were investigated using the point inoculation method with seeded antibiotics, PCR amplification, and sequencing for the determination of bacterial resistance profiles and class 1/2 integrase genes and gene cassettes, respectively. <b><i>Results:</i></b><i>sul1,</i><i>sul2,</i> and <i>sul3</i> were detected in 21.6, 27.8, and 0% of the isolates, respectively (n = 162). Class 1 and class 2 integrons were detected in 21.42 and 3.6% of the isolates, respectively (n = 168). Genes encoding resistance to aminoglycosides <i>(aadA2, aadA1,</i> and <i>aadB),</i> trimethoprim <i>(dfrA15, dfr7,</i> and <i>dfrA1),</i> and sulfonamide <i>(sul1)</i> were detected among bacteria with class 1 integrons, while genes that encodes resistance to strepthothricin <i>(sat2)</i> and trimethoprim <i>(dfrA15)</i> were detected among bacteria with class 2 integrons. <b><i>Conclusions:</i></b> Bacteria from these water samples are a potential reservoir of multidrug-resistant traits including sul genes and mobile resistance elements, i.e. the integrase gene.
DOI: 10.6084/m9.figshare.3444992
title: Macrobrachium australiense Assembly

description: This dataset represents the assembled DNA sequences obtained from 4 different cDNA libraries of a freshwater palaemonid prawn species, <i>Macrobrachium australiense</i>
DOI: 10.6084/m9.figshare.3444992.v1
title: Macrobrachium australiense Assembly

description: This dataset represents the assembled DNA sequences obtained from 4 different cDNA libraries of a freshwater palaemonid prawn species, <i>Macrobrachium australiense</i>
DOI: 10.6084/m9.figshare.3444917
title: NEON Data Institute 2016 - PowerPoint Presentations

description: Presentation given at the 2016 data institute.<br>
DOI: 10.6084/m9.figshare.3444917.v1
title: NEON Data Institute 2016 - Presentations

description: Presentation given at the 2016 data institute.<br>
DOI: 10.6084/m9.figshare.3444917.v2
title: NEON Data Institute 2016 - Presentations

description: Presentation given at the 2016 data institute.<br>
DOI: 10.6084/m9.figshare.3444917.v3
title: NEON Data Institute 2016 - Presentations

description: Presentation given at the 2016 data institute.<br>
DOI: 10.6084/m9.figshare.3444911
title: GM12878_chr22_features-pvalues.RData

description: R object of Hi-C genomic pairs with corresponding GC content and mappability values, and adjusted and nominal P values. The R object is data.table so data.table package must loaded to access the data in R.
DOI: 10.6084/m9.figshare.3444911.v1
title: GM12878_chr22_features-pvalues.RData

description: R object of Hi-C genomic pairs with corresponding GC content and mappability values, and adjusted and nominal P values. The R object is data.table so data.table package must loaded to access the data in R.
DOI: 10.6084/m9.figshare.3444908
title: Antibody Hybridization Dataset with Cytokeratin Probes and Contact Epithelial Cells

description: For this dataset, results are presented from antibody hybridization surveys of 'touch' or contact epithelial cells using cytokeratin (CK) probes.<br>Touch samples were collected from volunteers using the following protocol which was approved by the VCU-IRB (#HM20000454_CR). Contributors either rubbed a sterile polypropylene conical tube (P/N 229421; Celltreat Scientific) for five minutes using their entire hand (i.e., palm and fingers) and held it in their hands (no rubbing) for five minutes. Cells were then collected from the surface with six sterile pre-wetted swabs (P/N 22037924; Fisher Scientific) followed by two dry swabs. To elute the cells into solution, the swabs were manually stirred then vortexed for 15 seconds in 10 mL of ultrapure water (18.2 MΩ∙cm).<br>For antibody hybridization experiments, three milliliters of each cell solution were centrifuged at 5,000xg for five minutes. The supernatant was decanted and the pellet was resuspended in 100 µl PBS buffer and 1 µL of Human Fc Receptor block (Cat# 130-059-901, Miltenyi Biotec) to increase the specificity of antibody binding before reaction with CK probes. This was allowed to incubate at room temperature for 10 minutes. Cells were then incubated with either cytokeratin probe ‘AE1’ which recognizes CKs 10, 14, 15, 16 and 19 or 'AE3' which recognizes CKs 1, 2, 3, 4, 5, 6, 7, 8), Cat#s 14-9001-80 and 14-900-80, respectively, Affymetrix eBioscience) for 30 minutes followed by reaction with a secondary antibody, anti-mouse IgG1-APC (Cat# 17-4015-80, Affymetrix eBioscience). We used anti-mouse IgG1-APC (Cat#17-4714-42, Affymetrix eBioscience) to create the isotype control for AE1 experiments, incubating for 30 minutes. Cells were washed once and then resuspended in 1xFACS buffer prior to analysis.Flow cytometry analysis was performed on the BD FACSCanto™ II Analyzer (Becton Dickinson) equipped with 488nm and 633nm lasers. Channel voltages were set as follows: Forward Scatter (FSC, 150V), Side Scatter (SSC, 200V), Alexa Fluor 488 (FITC, 335V), Phycoerythrin (PE, 233V; PE-Cy5, 300V; PE-Cy7, 400V), and Allophycocyanin (APC, 250V).<br>Flow cytometry source data for all samples are provided in Flow Cytometry Standard (.fcs) format files. Source data files are labeled by date of collection, ID, and the antibody probe used. Isotype and unstained controls are included.
DOI: 10.6084/m9.figshare.3444908.v1
title: Antibody Hybridization Dataset with Cytokeratin Probes and Contact Epithelial Cells

description: For this dataset, results are presented from antibody hybridization surveys of 'touch' or contact epithelial cells using cytokeratin (CK) probes.<br>Touch samples were collected from volunteers using the following protocol which was approved by the VCU-IRB (#HM20000454_CR). Contributors either rubbed a sterile polypropylene conical tube (P/N 229421; Celltreat Scientific) for five minutes using their entire hand (i.e., palm and fingers) and held it in their hands (no rubbing) for five minutes. Cells were then collected from the surface with six sterile pre-wetted swabs (P/N 22037924; Fisher Scientific) followed by two dry swabs. To elute the cells into solution, the swabs were manually stirred then vortexed for 15 seconds in 10 mL of ultrapure water (18.2 MΩ∙cm).<br>For antibody hybridization experiments, three milliliters of each cell solution were centrifuged at 5,000xg for five minutes. The supernatant was decanted and the pellet was resuspended in 100 µl PBS buffer and 1 µL of Human Fc Receptor block (Cat# 130-059-901, Miltenyi Biotec) to increase the specificity of antibody binding before reaction with CK probes. This was allowed to incubate at room temperature for 10 minutes. Cells were then incubated with either cytokeratin probe ‘AE1’ which recognizes CKs 10, 14, 15, 16 and 19 or 'AE3' which recognizes CKs 1, 2, 3, 4, 5, 6, 7, 8), Cat#s 14-9001-80 and 14-900-80, respectively, Affymetrix eBioscience) for 30 minutes followed by reaction with a secondary antibody, anti-mouse IgG1-APC (Cat# 17-4015-80, Affymetrix eBioscience). We used anti-mouse IgG1-APC (Cat#17-4714-42, Affymetrix eBioscience) to create the isotype control for AE1 experiments, incubating for 30 minutes. Cells were washed once and then resuspended in 1xFACS buffer prior to analysis.Flow cytometry analysis was performed on the BD FACSCanto™ II Analyzer (Becton Dickinson) equipped with 488nm and 633nm lasers. Channel voltages were set as follows: Forward Scatter (FSC, 150V), Side Scatter (SSC, 200V), Alexa Fluor 488 (FITC, 335V), Phycoerythrin (PE, 233V; PE-Cy5, 300V; PE-Cy7, 400V), and Allophycocyanin (APC, 250V).<br>Flow cytometry source data for all samples are provided in Flow Cytometry Standard (.fcs) format files. Source data files are labeled by date of collection, ID, and the antibody probe used. Isotype and unstained controls are included.
DOI: 10.6084/m9.figshare.3444905
title: Assessing the genetic diversity in onion (<i>Allium cepa</i> L.) landraces from northwest Spain and comparison with the European variability

description: Fifteen onion landraces from Galicia (northwest Spain) were characterised with a set of 25 microsatellite markers and the genetic variability harboured by this collection was compared with the surrounding diversity by comparison with a representative panel of European onion landraces. Twenty markers were polymorphic allowing the detection of 121 alleles. Ninety-one of these were identified in the Galician group (average of 4.6 distinct alleles per locus) and 9% of the total number of alleles were recorded as unique alleles specifically contributed by onion landraces from northwest Spain. High values of observed and expected heterozygosities were detected for the majority of loci. Wright’s fixation index confirmed an excess of heterozygotes and a low level of inbreeding, suggesting that high levels of heterogeneity have accumulated within landraces. Multivariate and STRUCTURE analyses revealed that Galician onions possessed a specific genomic composition different from that found in European landraces.
DOI: 10.6084/m9.figshare.3444905.v1
title: Assessing the genetic diversity in onion (<i>Allium cepa</i> L.) landraces from northwest Spain and comparison with the European variability

description: Fifteen onion landraces from Galicia (northwest Spain) were characterised with a set of 25 microsatellite markers and the genetic variability harboured by this collection was compared with the surrounding diversity by comparison with a representative panel of European onion landraces. Twenty markers were polymorphic allowing the detection of 121 alleles. Ninety-one of these were identified in the Galician group (average of 4.6 distinct alleles per locus) and 9% of the total number of alleles were recorded as unique alleles specifically contributed by onion landraces from northwest Spain. High values of observed and expected heterozygosities were detected for the majority of loci. Wright’s fixation index confirmed an excess of heterozygotes and a low level of inbreeding, suggesting that high levels of heterogeneity have accumulated within landraces. Multivariate and STRUCTURE analyses revealed that Galician onions possessed a specific genomic composition different from that found in European landraces.
DOI: 10.6084/m9.figshare.3444899
title: From Manhatten to Manikarnika: A Study of the ‘Aghori’ Cult and Its Influence on the Life of Allen Ginsberg

description: My Paper entitled ‘From Manhatten to Manikarnika’ traces down the history of Allen Ginsberg’s stay in India. It aims to draw parallels between the Beat writers of the apocalyptic 60’s in America and the revered ‘Aghori’ sadhus in India. For an average American in the 60’s, the East, especially India was a queer nation, it was this queerness that fascinated the Beats writers of the 1960's in America. The reverence and reception of nudity, the celebration of the body, the adoration of death, the consumption of hallucinatory drugs for spiritual connection; approval of everything bizarre and gory lured the west to turn to the ‘heathen’ east for spiritual liberation from its constrained, materialistic society. The ‘aghoris’ managed to impress the Beat writers of the west to such an extent that Ginsberg ended up himself being a ‘yogi’ after his visit to India. Apart from Hinduism in general the one aspect that I wish to talk about and study in detail is the influence of the aghor philosophy on the mindset of Allen Ginsberg.
DOI: 10.6084/m9.figshare.3444884
title: Data from: Influence of prior contest experience and level of escalation on contest outcome

description: Contest data used for the analyses presented in the manuscript: "Influence of prior contest experience and level of escalation on contest outcome". <br>"male.id" = Identification number of a lizard"fight.id" = Identification number of a contest between two lizards"winner" = Two level factor indicating with lizard won the contest, 1 = winner of the contest, 0 = loser of the contest"duration" = Duration of the contest in seconds"con.init" = Two level factor indicating which lizard initiated the contest, 1 = initiator, 0 = non-initiator"escalate" = Two level factor indicating whether the contest escalated to physical biting or not, 1 = escalated, 0 = did not escalate "prior.win" = Two level factor indicating whether lizard won in the previous contest, 1 = won previous contest, 0 = did not win previous contest"mass" = Body mass of the lizard in grams"sc.mass" = Z-transformed body mass of a lizard."massdiff" = Difference in "sc.mass" between the opponents"tot.bite" = Total number of times a lizard bit his opponent"r.tot.bite" = Rank transformed and normalised "tot.bite". This was calculated using quantiles from a normal distribution with mean = 0 and standard deviation = 1. <br>
DOI: 10.6084/m9.figshare.3444884.v1
title: Data from: Influence of prior contest experience and level of escalation on contest outcome

description: Contest data used for the analyses presented in the manuscript: "Influence of prior contest experience and level of escalation on contest outcome". <br>"male.id" = Identification number of a lizard"fight.id" = Identification number of a contest between two lizards"winner" = Two level factor indicating with lizard won the contest, 1 = winner of the contest, 0 = loser of the contest"duration" = Duration of the contest in seconds"con.init" = Two level factor indicating which lizard initiated the contest, 1 = initiator, 0 = non-initiator"escalate" = Two level factor indicating whether the contest escalated to physical biting or not, 1 = escalated, 0 = did not escalate "prior.win" = Two level factor indicating whether lizard won in the previous contest, 1 = won previous contest, 0 = did not win previous contest"mass" = Body mass of the lizard in grams"sc.mass" = Z-transformed body mass of a lizard."massdiff" = Difference in "sc.mass" between the opponents"tot.bite" = Total number of times a lizard bit his opponent"r.tot.bite" = Rank transformed and normalised "tot.bite". This was calculated using quantiles from a normal distribution with mean = 0 and standard deviation = 1. <br>
DOI: 10.6084/m9.figshare.3444866
title: All Combination Unigenes

description: Transcriptome assembly of Coptotermes formosanus<br>
DOI: 10.6084/m9.figshare.3444866.v1
title: All Combination Unigenes

description: Transcriptome assembly of Coptotermes formosanus<br>
DOI: 10.6084/m9.figshare.3444842
title: Demo 5: Gaze-Activated Mixed Reality Mobile Media Browser for Virtual Reality Television

description: This paper describes a mixed reality (MR) media browser that utilizes only the user’s gaze for interacting, opening, playing, and pausing 360-degree VR televisual films. The system enables hands-free interaction that activates the passive spectator by encouraging them to move about the physical world. As they shift their gaze, they engage with content in the MR environment and initiate VR films. This affords an immersive media browsing experience via a stylized MR scene with 3D-objects as representations of VR videos. The system is illustrative of a unique interaction design paradigm that augments the user’s gaze as a functional touch event. Its development aligns with current trends in interactive television in which screens are being replaced by goggles. It has been developed for Georgia Tech’s Argon AR Browser for the iPhone and can be viewed via a HUD such as Google Cardboard.