cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.25549/one-c4-6615
title: ONE magazine 1/8 (1953-08)

description: ONE magazine, volume 1, number 8 (1953 August). Issued monthly.
DOI: 10.25549/one-c4-18090
title: ONEletter 33/9 (1988-09)

description: ONEletter, volume 33, number 9 (1988 September). Issued monthly.
DOI: 10.25549/one-c4-18810
title: ONEletter 33/10 (1988-10)

description: ONEletter, volume 33, number 10 (1988 October). Issued monthly.
DOI: 10.25549/one-c4-17169
title: ONEletter 33/12 (1988-12)

description: ONEletter, volume 33, number 12 (1988 December). Issued monthly.
DOI: 10.25549/one-c4-28576
title: Fernand A., letters (1968)

description: Fernand A., letters and response from W. Dorr Legg (1968)
DOI: 10.25549/one-c4-25474
title: ONE, Inc. history, drafts and pamphlets (1982)

description: ONE, Inc. history, including timelines and pamphlets about gay and lesbian pioneers
DOI: 10.25549/one-c4-8817
title: ONE magazine 8/2 (1960-02)

description: ONE magazine, volume 8, number 2 (1960 February). Issued monthly.
DOI: 10.25549/one-c4-28596
title: Gordie A., letters (1963)

description: Gordie A., letters (1963)
DOI: 10.25549/one-c4-27121
title: ONE, Inc. meeting minutes (1982)

description: ONE, Inc. minutes for the annual, trustees, and board of directors meetings (1982)
DOI: 10.25549/one-c4-29412
title: Richard A., letters (1960/1968)

description: Richard A., envelopes, forms, letters, notes (1960/1968)
DOI: 10.25549/one-c4-29749
title: Sherry A., letters (1963)

description: Sherry A., forms, letters (1963)
DOI: 10.25549/one-c4-8715
title: ONE magazine 7/5 (1959-05)

description: ONE magazine, volume 7, number 5 (1959 May). Issued monthly.
DOI: 10.25549/whit-m7314
title: Estelle Etteve & orange juice, Southern California, 1932

description: 6 photographs of Estelle Etteve holding a glass of orange juice, Southern California, 1932. "Subject: Estelle Etteve & Orange Juice; Client: Gordon Provonsha, c/o Beaumont & Hohman; Original print order: #1-2, 1 Ea[ch]; Size: 11x14; Finish: glos[sy]; Re-order: 1#1; Size: 11x14; Finish: gl[ossy], flop neg[ative]; Year: 1932; Job: 10-15-86" -- on envelope front. "Model (Name): 5.00; He paid 5.00 for the model and he owes us 15.00 more if the job is accepted; Operator's report (Name): Dick" -- on envelope back.
DOI: 10.25549/one-c4-29642
title: Frits Bernard, letters (1973)

description: Frits Bernard, article, letter (1973)
DOI: 10.25549/one-c4-29325
title: Adrienne A., letters (1965)

description: Adrienne A., envelope, letters (1965)
DOI: 10.25549/one-c4-18287
title: ONEletter 40/3 [39/3] (1994-03)

description: ONEletter, volume 40 [39], number 3 (1994 March). Issued monthly.
DOI: 10.25549/one-c4-28579
title: Horst A., letters (1963)

description: Horst A., letters and response from W. Dorr Legg (1963)
DOI: 10.25549/one-c4-6676
title: ONE magazine 1/10 (1953-10)

description: ONE magazine, volume 1, number 10 (1953 October). Issued monthly.
DOI: 10.25549/one-c4-29638
title: Dene A., letters (1957/1961)

description: Dene A., letters, notes (1957/1961)
DOI: 10.25549/whit-m13912
title: Toys, Broadway Department Store, Southern California, 1925

description: 7 photographs of children playing with toys, Southern California, 1925. "Subject: Toys; Client: Broadway Department Store; Year: 1925; Job: 10-20-25" -- on envelope.
DOI: 10.25549/one-c4-17123
title: ONEletter 36/9 (1991-09)

description: ONEletter, volume 36, number 9 (1991 September). Issued monthly.
DOI: 10.25549/one-c4-17043
title: ONEletter 36/7 (1991-07)

description: ONEletter, volume 36, number 7 (1991 July). Issued monthly.
DOI: 10.25549/one-c4-1192
title: ONE Magazine index, volume 2, 1954
DOI: 10.25549/one-c4-1201
title: ONE Magazine index, volume 3, 1955
DOI: 10.25549/one-c4-1217
title: ONE Magazine index, volume 5, 1957
DOI: 10.25549/one-c4-1208
title: ONE Magazine index, volume 4, 1956
DOI: 10.25549/one-c4-1234
title: ONE Magazine index, volume 6, 1958
DOI: 10.25549/whit-m9274
title: Copy of Studebaker for enlarging, Muroc Dry Lake, Southern California, 1932

description: Photograph of copy of photograph of Studebaker automobile, Muroc Dry Lake, Southern California, 1932. "Subject: copy of Studebaker for enlarging - Muroc Dry Lake; Client: Pennzoil; Original Print Order: 1-; Size: 11x14; Finish: gl[ossy]; Job: 1-26-142; Year: 1932" -- on envelope front. "1 Copies (Print Extra); Amount: $1.00; Extra Charges: #315" -- on envelope back.
DOI: 10.25549/whit-m6763
title: Interior of store, West 7th Street, Southern California, 1931

description: Photograph of the interior of a store, Southern California, 1931. "Subject: Interior of store, W[est] 7th st[reet]; Client: I. Miller; Original Print Order: 2; Size: 8x10; Finish: gloss; Job: 7-16-79; Year: 1931" -- on envelope front. "Operator's Report (Name): 'Dick'; Original Photographs-Size: 1 8x10 interior; Amount: 3.00, 1.00" -- on envelope back.
DOI: 10.25549/one-c4-1251
title: ONE Magazine index, volume 7, 1959
DOI: 10.25549/one-c4-1258
title: ONE Magazine index, volume 8, 1960
DOI: 10.25549/one-c4-1265
title: ONE Magazine index, volume 9, 1961
DOI: 10.25549/one-c4-1272
title: ONE Magazine index, volume 10, 1962
DOI: 10.25549/one-c4-1279
title: ONE Magazine index, volume 11, 1963
DOI: 10.25549/one-c4-1292
title: ONE Magazine index, volume 12, 1964
DOI: 10.25549/one-c4-1305
title: ONE Magazine index, volume 13, 1965
DOI: 10.25549/one-c4-29485
title: Wallace A., letters (1958/1962)

description: Wallace A., cards, envelopes, forms, letters, notes, response from Bill Lambert (W. Dorr Legg) (1958/1962)
DOI: 10.25549/one-c4-17428
title: ONEletter 35/4 (1990-04)

description: ONEletter, volume 35, number 4 (1990 April). Issued monthly.
DOI: 10.25549/one-c4-17511
title: ONEletter 35/6 (1990-06)

description: ONEletter, volume 35, number 6 (1990 June). Issued monthly.
DOI: 10.25549/one-c4-1314
title: ONE Magazine index, volume 14, 1966
DOI: 10.25549/one-c4-1319
title: ONE Magazine index, volume 15, 1967
DOI: 10.25549/one-c4-8748
title: ONE magazine 7/6 (1959-06)

description: ONE magazine, volume 7, number 6 (1959 June). Issued monthly.
DOI: 10.25549/whit-m9773
title: Portrait of Mr. Grant, Southern California, 1932

description: Photographic portrait of Mr. Grant, Southern California, 1932. "Subject: Portrait of Mr. Grant; Client: Playground dep[artmen]t; Original Print Order: 1; Size: 8x10; Finish: gl[ossy]; Year: 1932; Job: 1-14-64" -- on envelope front. "Operator's Report (Name): Joe; 1 Original Photographs-- At Studio: 8x10; Amount: 2.00, 1.00; Extra Charges: Freidman" -- on envelope back.
DOI: 10.25549/one-c4-28600
title: Lewis A., letters (1971)

description: Lewis A., forms (1971)
DOI: 10.25549/one-c4-30043
title: George A., letters (1954/1957)

description: George A., forms, letters and responses from David L. Freeman and Scotti Williams (1954/1957)
DOI: 10.25549/one-c4-19080
title: ONEletter 35/7 (1990-07)

description: ONEletter, volume 35, number 7 (1990 July). Issued monthly.
DOI: 10.25549/one-c4-27172
title: ONE, Inc. meeting minutes (1986)

description: ONE, Inc. minutes for the annual, trustees, and board of directors meetings (1986)
DOI: 10.25549/one-c4-11509
title: ONE magazine 14/5 (1966-06)

description: ONE magazine, volume 14, number 5 (1966 June). Issued monthly.
DOI: 10.25549/one-c4-30053
title: Hermes A., letters (1963)

description: Hermes A., note (1963)
DOI: 10.25549/one-c4-28627
title: Harold A., letters (1957/1958)

description: Harold A., cards, form, letter (1957/1958)
DOI: 10.25549/one-c4-29836
title: Bernhard A., letters (1956)

description: Bernhard A., letter (1956)
DOI: 10.25549/one-c4-19013
title: ONEletter 37/3 (1992-03)

description: ONEletter, volume 37, number 3 (1992 March). Issued monthly.
DOI: 10.25549/one-c4-19140
title: ONEletter 37/2 (1992-02)

description: ONEletter, volume 37, number 2 (1992 February). Issued monthly.
DOI: 10.25549/one-c4-17871
title: ONEletter 35/8 (1990-08)

description: ONEletter, volume 35, number 8 (1990 August). Issued monthly.
DOI: 10.25549/one-c4-16998
title: ONEletter 35/11 (1990-11)

description: ONEletter, volume 35, number 11 (1990 November). Issued monthly.
DOI: 10.25549/one-c4-22716
title: ONE, Inc. promotional materials;  member subscription (1980/1989)

description: ONE, Inc. promotional materials, including direct mail, brochures, fliers, membership forms, and subscription form (1980/1989).
DOI: 10.25549/one-c4-23276
title: ONE, Inc. promotional materials (1964/1974)

description: ONE, Inc. promotional materials, including direct mail, brochures, fliers, membership forms, and subscription form  (1964/1974).
DOI: 10.25549/one-c4-28398
title: Richard A., letters (1971)

description: Richard A., layouts, letters and response from W. Dorr Legg (1971)
DOI: 10.25549/one-c4-16646
title: ONEletter 35/5 (1990-05)

description: ONEletter, volume 35, number 5 (1990 May). Issued monthly.
DOI: 10.25549/one-c4-29387
title: Bill A., letters (1959/1961)

description: Bill A., form, letters (1959/1961)
DOI: 10.25549/one-c4-7073
title: ONE magazine 2/10 (1954-12)

description: ONE magazine, volume 2, number 10 (1954 December). Issued monthly.
DOI: 10.25549/one-c4-6434
title: ONE magazine 1/2 (1953-02)

description: ONE magazine, volume 1, number 2 (1953 February). Issued monthly.
DOI: 10.25549/one-c4-10237
title: ONE magazine 11/2 (1963-02)

description: ONE magazine, volume 11, number 2 (1963 February). Issued monthly.
DOI: 10.25549/one-c4-6492
title: ONE magazine 1/4 (1953-04)

description: ONE magazine, volume 1, number 4 (1953 April). Issued monthly.
DOI: 10.25549/one-c4-6463
title: ONE magazine 1/3 (1953-03)

description: ONE magazine, volume 1, number 3 (1953 March). Issued monthly.
DOI: 10.25549/one-c4-28499
title: American Civil Liberties Union, letters (1965/1985)

description: Letters to and from American Civil Liberties Union of Southern California and other ACLU chapters and representives from ONE Incorporated, which include clippings, manuscript drafts, fliers, programs, and reports (1965/1985)
DOI: 10.25549/one-c4-26162
title: ONE, Inc. history, foundation

description: ONE, Inc. history: An index of corporation and departmental policies and decisions of ONE Incorporated
DOI: 10.25549/one-c4-17953
title: ONEletter 31/7 (1986-07)

description: ONEletter, volume 31, number 7 (1986 July). Issued monthly.
DOI: 10.25549/one-c4-18400
title: ONEletter 31/5 (1986-05)

description: ONEletter, volume 31, number 5 (1986 May). Issued monthly.
DOI: 10.25549/one-c4-32145
title: Elver Barker (Carl B. Harding), letters (1954/2000)

description: Elver Barker (Carl Bosworth Harding), business card, cards, forms, letters, script, and response from Ann Carll Reid, on a variety of topics including homosexuality, education handbook, publication rights, and Timberline Art Studio; also includes response from William Lambert (W. Dorr Legg) (1954/2000)
DOI: 10.25549/one-c4-29552
title: Allen's Press Clipping Bureau, letters (1957)

description: Allen's Press Clipping Bureau, letters (1957)
DOI: 10.25549/one-c4-29139
title: Luther A., letters (1969)

description: Luther A., fliers, letters and response from W. Dorr Legg (1969)
DOI: 10.25549/one-c4-28283
title: Kurt A., letters (1965)

description: Kurt A., letter (1965)
DOI: 10.25549/one-c4-29926
title: J. A., letters (1963)

description: J. A., envelope, form, letter (1963)
DOI: 10.25549/one-c4-17820
title: ONEletter 34/10 (1989-10)

description: ONEletter, volume 34, number 10 (1989 October). Issued monthly. Includes a press release from the National Gay and Lesbian Task Force (NGLTF).
DOI: 10.25549/one-c4-14405
title: ONE, Inc. meeting minutes (1978)

description: Minutes for the annual, trustees, board of directors, ad hoc meetings (1978)
DOI: 10.25549/one-c4-27421
title: ONE, Inc. meeting minutes (1982)

description: ONE, Inc. minutes and recommendations for the administrative council meetings (1982)
DOI: 10.25549/one-c4-29131
title: Jorge A., letters (1954/1958)

description: Jorge A., forms, letters, postcards (1954/1958)
DOI: 10.25549/one-c4-8784
title: ONE magazine 7/7 (1959-07)

description: ONE magazine, volume 7, number 7 (1959 July). Issued monthly.
DOI: 10.25549/one-c4-12896
title: ONE confidential 11/2 (1966-02)

description: ONE confidential, volume 11, number 2 (1966 February). Issued monthly.
DOI: 10.25549/one-c4-16849
title: ONEletter 31/6 (1986-06)

description: ONEletter, volume 31, number 6 (1986 June). Issued monthly.
DOI: 10.25549/one-c4-12762
title: ONE confidential 11/4 (1966-04)

description: ONE confidential, volume 11, number 4 (1966 April). Issued monthly.
DOI: 10.25549/one-c4-6405
title: ONE magazine 1/1 (1953-01)

description: ONE magazine, volume 1, number 1 (1953 January). Issued monthly.
DOI: 10.25549/one-c4-10101
title: ONE magazine 10/10 (1962-10)

description: ONE magazine, volume 10, number 10 (1962 October). Issued monthly.
DOI: 10.25549/one-c4-17057
title: ONEletter 31/9 (1986-09)

description: ONEletter, volume 31, number 9 (1986 September). Issued monthly.
DOI: 10.25549/one-c4-17206
title: ONEletter 31/10 (1986-10)

description: ONEletter, volume 31, number 10 (1986 October). Issued monthly.
DOI: 10.25549/one-c4-17233
title: ONEletter 31/3 (1986-03)

description: ONEletter, volume 31, number 3 (1986 March). Issued monthly.
DOI: 10.25549/one-c4-16579
title: ONEletter 31/4 (1986-04)

description: ONEletter, volume 31, number 4 (1986 April). Issued monthly.
DOI: 10.25549/one-c4-10204
title: ONE magazine 11/1 (1963-01)

description: ONE magazine, volume 11, number 1 (1963 January). Issued monthly.
DOI: 10.25549/one-c4-29119
title: George A., letters (1954/1961)

description: George A., business card, clippings, envelopes, forms, greeting card, layouts, fliers, letters, and notes (1954/1961)
DOI: 10.25549/whit-m9659
title: Plymouth coupe after repaired, Southern California, 1934

description: Photograph of automobile, Southern California, 1934. "Subject: Plymouth coupe after repaired; Client: Greet-Robbins; Original Print Order: 1; Size: 8x10; Finish: gl[ossy]; Mount: linen 8 [inches]; Year: 1934; Job: 7-21-70" -- on envelope front. "Operator's Report Name: Dean; 1 Original Photographs--Size: 8x10; Amount: 3.00" -- on envelope back.
DOI: 10.25549/one-c4-16893
title: ONEletter 31/8 (1986-08)

description: ONEletter, volume 31, number 8 (1986 August). Issued monthly.
DOI: 10.25549/one-c4-17183
title: ONEletter 31/2 (1986-02)

description: ONEletter, volume 31, number 2 (1986 February). Issued monthly.
DOI: 10.25549/one-c4-25749
title: ONE, Inc. history, articles and drafts

description: ONE, Inc. history articles, including two manuscript drafts
DOI: 10.25549/one-c4-29328
title: Max A., letters (1959/1960)

description: Max A., form (1959/1960)
DOI: 10.25549/one-c4-16934
title: ONEletter 30/12 (1985-12)

description: ONEletter, volume 30, number 12 (1985 December). Issued monthly.
DOI: 10.25549/one-c4-16556
title: ONEletter 31/1 (1986-01)

description: ONEletter, volume 31, number 1 (1986 January). Issued monthly.
DOI: 10.25549/one-c4-28620
title: Ray A., letters (1969)

description: Ray A., letter (1969)
DOI: 10.25549/one-c4-17790
title: ONEletter 35/1 (1990-01)

description: ONEletter, volume 35, number 1 (1990 January). Issued monthly.
DOI: 10.25549/one-c4-30030
title: C. A., letters (1961/1970)

description: C. A., forms, leaflet, letters, memorandums, newsletter, notes, programs; responses from W. Dorr Legg and Lewis Bonham (1961/1970)
DOI: 10.25549/one-c4-26797
title: ONE, Inc. meeting minutes (1983)

description: ONE, Inc. minutes for the annual, trustees, and board of directors meetings (1983)
DOI: 10.25549/one-c4-28744
title: Russell A., letters (1966)

description: Russell A., letters and response from W. Dorr Legg (1966)
DOI: 10.25549/one-c4-16780
title: ONEletter 37/1 (1992-01)

description: ONEletter, volume 37, number 1 (1992 January). Issued monthly.
DOI: 10.25549/one-c4-18507
title: ONEletter 37/5 (1992-05)

description: ONEletter, volume 37, number 5 (1992 May). Issued monthly.
DOI: 10.25549/one-c4-28553
title: David A., letters (1957/1974)

description: David A., cards, forms, letters and responses from William Lambert (W. Dorr Legg) (1957/1974)
DOI: 10.25549/one-c4-19112
title: ONEletter 37/7 (1992-07)

description: ONEletter, volume 37, number 7 (1992 July). Issued monthly.
DOI: 10.25549/one-c4-18867
title: ONEletter 37/4 (1992-04)

description: ONEletter, volume 37, number 4 (1992 April). Issued monthly.
DOI: 10.25549/one-c4-18151
title: ONEletter 37/8 (1992-08)

description: ONEletter, volume 37, number 8 (1992 August). Issued monthly.
DOI: 10.25549/one-c4-13024
title: ONE confidential 4/8 (1959-08)

description: ONE confidential, volume 4, number 8 (1959 August). Issued monthly.
DOI: 10.25549/one-c4-18950
title: ONEletter 37/9 (1992-09)

description: ONEletter, volume 37, number 9 (1992 September). Issued monthly.
DOI: 10.25549/one-c4-16491
title: ONEletter 37/12 (1992-12)

description: ONEletter, volume 37, number 12 (1992 December). Issued monthly.
DOI: 10.25549/one-c4-17240
title: ONEletter 37/11 (1992-11)

description: ONEletter, volume 37, number 11 (1992 November). Issued monthly.
DOI: 10.25549/one-c4-29442
title: F. A., letters (1965)

description: F. A., envelope, form (1965)
DOI: 10.25549/one-c4-27188
title: ONE, Inc. meeting minutes (1985)

description: ONE, Inc. minutes for the academic council meetings (1985)
DOI: 10.25549/pcra-c14-253338
title: The whole truth [newspaper], vol. 7, no. 2 (1974 Mar.)

description: The whole truth [newspaper], vol. 7, no. 2 (1974 March). Monthly, except bi-monthly in December-January.
DOI: 10.25549/whit-m13270
title: Salesman getting the 'dope' on new tire, Southern California, 1931

description: 8 photographs of men and tires, Southern California, 1931. "Subject: Salesman getting the 'Dope' on new tire; Agency: Weinberg; Client: Nelson & Price; Original Print Order: 1 ea[ch]; Re-Order: 1 ea[ch], 1 ea[ch] except 2 3 6; Size: 8x10; Finish: gl[ossy]; Year: 1931; Job: 11-5-30" -- on envelope front. "Name: Joe; 8 - 8x10; In City: 8.00; Extra Charges: Bernie #6378" -- on envelope back.
DOI: 10.25549/one-c4-17612
title: ONEletter 32/7 (1987-07)

description: ONEletter, volume 32, number 7 (1987 July). Issued monthly.
DOI: 10.25549/one-c4-11459
title: ONE magazine 14/3 (1966-03)

description: ONE magazine, volume 14, number 3 (1966 March). Issued monthly.
DOI: 10.25549/one-c4-11393
title: ONE magazine 14/1 (1966-01)

description: ONE magazine, volume 14, number 1 (1966 January). Issued monthly.
DOI: 10.25549/one-c4-16694
title: ONEletter 32/11 (1987-11)

description: ONEletter, volume 32, number 11 (1987 November). Issued monthly.
DOI: 10.25549/one-c4-28342
title: Anderson Association, letters (1968)

description: Anderson Association, letters and response from Robert Gregory (1968)
DOI: 10.25549/one-c4-11526
title: ONE magazine 14/7 [6] (1966-07)

description: ONE magazine, volume 14, number 7 [6] (1966 July). Issued monthly.
DOI: 10.25549/one-c4-28844
title: Carl A., letters (1963)

description: Carl A., forms, letters (1963)
DOI: 10.25549/one-c4-29681
title: R. A., letters (1965)

description: R. A., card (1965)
DOI: 10.25549/one-c4-16812
title: ONEletter 38/11 (1993-11)

description: ONEletter, volume 38, number 11 (1993 November). Issued monthly.
DOI: 10.25549/one-c4-16498
title: ONEletter 38/12 (1993-12)

description: ONEletter, volume 38, number 12 (1993 December). Issued monthly.
DOI: 10.25549/one-c4-29314
title: Lynn A., letters (1964)

description: Lynn A., forms, notes (1964)
DOI: 10.25549/one-c4-29571
title: Herbert A., letters (1954/1957)

description: Herbert A., forms, letters, notes (1954/1957)
DOI: 10.25549/one-c4-25945
title: Untitled counseling manual

description: Untitled counseling manual
DOI: 10.25549/one-c4-18238
title: ONEletter 33/1 (1988-01)

description: ONEletter, volume 33, number 1 (1988 January). Issued monthly.
DOI: 10.25549/one-c4-16536
title: ONEletter 32/12 (1987-12)

description: ONEletter, volume 32, number 12 (1987 December). Issued monthly.
DOI: 10.25549/one-c4-17340
title: ONEletter 33/2 (1988-02)

description: ONEletter, volume 33, number 2 (1988 February). Issued monthly.
DOI: 10.6084/m9.figshare.18783164
title: Dataset for: A Petri Net Approach to Physiologically Based Toxicokinetic (PBTK) Modeling

description: Physiologically based toxicokinetic (PBTK) modeling enables researchers to predict internal tissue concentrations for various species exposed to exogenous compounds through different routes at varying concentrations without having to run in vivo experiments for each scenario. Parameters for the models may be gathered from in vivo or in vitro measurements, cross species or cross chemical extrapolations, literature reviews, or other models. PBTK models, described using ordinary differential equations (ODEs), are then simulated using these parameters for a given compound / exposure / species scenario. Though potentially useful for regulatory toxicology, the complexity of ODE programming and simulation remains a barrier for many would be researchers. Petri Nets (PN), a graphical modeling framework, offers a more intuitive approach to PBTK modeling. To demonstrate the utility and ease of use, we present a model of waterborne fluoranthene exposure to rainbow trout (Oncorhynus mykiss) written and simulated in Snoopy, a graphical PN development and simulation software package. We converted an existing ODE PBTK model and evaluated the PN model against the ODE model results. The simulated tissue concentrations of the PN model closely mirrored the simulated concentrations of the ODE model. In order to convert the ODE model to a PN model, we introduced a new parameter ‘Blood Volume (VBLOOD)'. Sensitivity analysis found VBLOOD to be very robust when varied over an order of magnitude. The resulting PN PBTK model has a number of advantages over ODE models, while maintaining equivalent predictive functionality.
DOI: 10.6084/m9.figshare.18783164.v1
title: Dataset for: A Petri Net Approach to Physiologically Based Toxicokinetic (PBTK) Modeling

description: Physiologically based toxicokinetic (PBTK) modeling enables researchers to predict internal tissue concentrations for various species exposed to exogenous compounds through different routes at varying concentrations without having to run in vivo experiments for each scenario. Parameters for the models may be gathered from in vivo or in vitro measurements, cross species or cross chemical extrapolations, literature reviews, or other models. PBTK models, described using ordinary differential equations (ODEs), are then simulated using these parameters for a given compound / exposure / species scenario. Though potentially useful for regulatory toxicology, the complexity of ODE programming and simulation remains a barrier for many would be researchers. Petri Nets (PN), a graphical modeling framework, offers a more intuitive approach to PBTK modeling. To demonstrate the utility and ease of use, we present a model of waterborne fluoranthene exposure to rainbow trout (Oncorhynus mykiss) written and simulated in Snoopy, a graphical PN development and simulation software package. We converted an existing ODE PBTK model and evaluated the PN model against the ODE model results. The simulated tissue concentrations of the PN model closely mirrored the simulated concentrations of the ODE model. In order to convert the ODE model to a PN model, we introduced a new parameter ‘Blood Volume (VBLOOD)'. Sensitivity analysis found VBLOOD to be very robust when varied over an order of magnitude. The resulting PN PBTK model has a number of advantages over ODE models, while maintaining equivalent predictive functionality.
DOI: 10.25549/one-c4-6521
title: ONE magazine 1/5 (1953-05)

description: ONE magazine, volume 1, number 5 (1953 May). Issued monthly.
DOI: 10.25549/one-c4-28290
title: Gerry A., letter (1967)

description: Gerry A., letter and response from W. Dorr Legg (1967)
DOI: 10.25549/one-c4-18677
title: ONEletter 31/11 (1986-11)

description: ONEletter, volume 31, number 11 (1986 November). Issued monthly.
DOI: 10.25549/one-c4-8959
title: ONE magazine 7/9 (1959-09)

description: ONE magazine, volume 7, number 9 (1959 September). Issued monthly.
DOI: 10.25549/one-c4-10171
title: ONE magazine 10/12 (1962-12)

description: ONE magazine, volume 10, number 12 (1962 December). Issued monthly.