cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.5129899.v1
title: Supplementary Material for: Aufmerksamkeitsdefizit-/Hyperaktivitätsstörung über die Lebensspanne

description: Die Aufmerksamkeitsdefizit-/Hyperaktivitätsstörung (ADHS) ist eine Störung mit Beginn in der Kindheit und Jugend. Die Persistenzraten für das Erwachsenenalter liegen allerdings zwischen 20 bis über 80%. Demnach handelt es sich um eine chronische Störung, die über die Lebensspanne hinweg zu erheblichen Beeinträchtigungen führen kann. In diesem Übersichtsartikel werden zunächst die Symptomatik, Klassifikation, Komorbidität und Epidemiologie der Störung dargestellt, wobei auf Unterschiede in den verschiedenen Lebensphasen (Kindes-, Jugend- und Erwachsenenalter) eingegangen wird. Daran anschließend wird die ADHS als Entwicklungsstörung dargestellt und mögliche Entwicklungspfade und Risikofaktoren werden beschrieben. Abschließend werden diagnostische und therapeutische Ansätze in den unterschiedlichen Lebensphasen vorgestellt.
DOI: 10.6084/m9.figshare.5129890
title: Supplementary Material for: In-Office Hyaluronate Injection Laryngoplasty as Palliative Treatment for Unilateral Vocal Fold Paralysis

description: <b><i>Background:</i></b> Voice and swallowing impairments can impact on both quality of life and survival. Unilateral vocal fold paralysis (UVFP) as a result of distant metastasis can cause breathy voice and aspiration. The purpose of this study is to develop and evaluate a less invasive and effective alternative therapy for UVFP. <b><i>Methods:</i></b> This was a retrospective review of prospectively enrolled patients at a tertiary referral center in Taiwan. Among a cohort of 177 patients who received intracordal hyaluronate injections, 2 had UVFP from distant metastasis and met the inclusion criteria. Vocal cord motion was recorded by videostroboscopy, and the normalized glottal gap area was measured. Voice quality, defined by speech language pathologists, and swallowing status were compared, and immediate complications after the injection were investigated. <b><i>Results:</i></b> Two patients with UVFP with M1 lesions (both lung) accepted the procedure. The glottal gap area was significantly improved 1 month after in-office hyaluronate injection. Voice quality and aspiration were also improved. No immediate complications were noted in either patient. <b><i>Conclusions:</i></b> In-office intracordal hyaluronate injection is a safe and effective treatment for UVFP, providing a palliative method to help maintain the patient's voice and quality of life.
DOI: 10.6084/m9.figshare.5129902.v1
title: Supplementary Material for: Skin Care in the Tattoo Parlor: A Survey of Tattoo Artists in New York City

description: To understand the role that tattooists play in providing skin care advice, we conducted an online, survey-based study of 90 licensed tattooists in New York City. The survey asked tattooists about their exposure to adverse tattoo events, advising on tattoo removal/correction, behaviors regarding preexisting skin conditions and aftercare, confidence in addressing client questions about adverse events and preexisting conditions, and prior training about skin conditions related to tattoos. Most tattooists (92.8%) reported being asked by clients to evaluate adverse tattoo reactions, 85% were asked about tattoo removal, and 90% were asked about the safety of getting a tattoo with a preexisting skin condition. About half (56.1%) had received training about skin conditions related to tattoos. Tattooists with prior training reported higher rates of optimal skin care behaviors and higher confidence with tattoo-related skin conditions; 91.4% reported interest in skin care education. Tattooists play a major role in the skin health of their clients. Providing education for tattooists may improve skin care in populations less likely to see a dermatologist.
DOI: 10.6084/m9.figshare.5129881
title: Supplementary Material for: Gesture Performance in First- and Multiple-Episode Patients with Schizophrenia Spectrum Disorders

description: <b><i>Background/Aim:</i></b> Gesturing plays an important role in social behavior and social learning. Deficits are frequent in schizophrenia and may contribute to impaired social functioning. Information about deficits during the course of the disease and presence of severity and patterns of impairment in first-episode patients is missing. Hence, we aimed to investigate gesturing in first- compared to multiple-episode schizophrenia patients and healthy controls. <b><i>Methods:</i></b> In 14 first-episode patients, 14 multiple-episode patients and 16 healthy controls matched for age, gender and education, gesturing was assessed by the comprehensive Test of Upper Limb Apraxia. Performance in two domains of gesturing - imitation and pantomime - was recorded on video. Raters of gesture performance were blinded. <b><i>Results:</i></b> Patients with multiple episodes had severe gestural deficits. For almost all gesture categories, performance was worse in multiple- than in first-episode patients. First-episode patients demonstrated subtle deficits with a comparable pattern. <b><i>Conclusions:</i></b> Subjects with multiple psychotic episodes have severe deficits in gesturing, while only mild impairments were found in first-episode patients independent of age, gender, education and negative symptoms. The results indicate that gesturing is impaired at the onset of disease and likely to further deteriorate during its course.
DOI: 10.6084/m9.figshare.5129884
title: Supplementary Material for: Component-Resolved Diagnosis of Peanut Allergy and Its Possible Origins of Sensitization in China

description: <b><i>Background:</i></b> Clinical and immunological characteristics of food allergies vary depending on geographic regions. Little is known about peanut allergy in China. The aim of this study was to investigate the peanut sensitization profile in China. <b><i>Methods:</i></b> Thirty-eight participants with immunoglobulin E (IgE)-positive responses to peanuts (peanut-sensitized) were included in our study, and clinical characteristics were evaluated. Total and specific IgE reactivity against peanuts, other plant-derived foods, pollens, and related allergen components were determined. <b><i>Results:</i></b> Eighteen patients were symptomatic when exposed to peanuts. The majority of them presented with systemic reactions. More than half of the peanut-sensitized subjects also suffered from mugwort pollinosis and peach allergy. In patients with both peanut and peach allergies, reactions to peanuts were the same as or severer than those to peaches. Positivity rates of IgE response to rAra h 1-3, 8, and 9 in the peanut allergy group were 5.6, 11.1, 5.6, 22.2, and 83.3%, respectively. 66.7% (12/18) of the peanut-allergic patients were monosensitized to rAra h 9. Anti-nArt v 3 [mugwort nonspecific lipid transfer protein (nsLTP)] IgE positivity in the peanut allergy group was significantly higher than that in the asymptomatic peanut-sensitized group. In Ara h 9 (peanut nsLTP)-sensitized patients with mugwort pollinosis, anti-nArt v 3 IgE levels were remarkably higher than anti-rAra h 9 (peanut nsLTP) IgE levels as well as anti-Pru p 3 (peach nsLTP) IgE levels. <b><i>Conclusions:</i></b> Ara h 9 was the major allergen of peanut, and Ara h 9 monosensitization was the most common peanut sensitization pattern in our population. Furthermore, there was a strong correlation between peanut sensitization and mugwort pollinosis, as well as peach allergy, in our country.
DOI: 10.6084/m9.figshare.5129887
title: Supplementary Material for: «Nicht von schlechten Eltern!» Effekte einer therapieintegrierten Familienintervention

description: <b><i>Hintergrund:</i></b> Eine psychische Erkrankung bringt viele Belastungen mit sich. Insbesondere die Kinder psychisch kranker Eltern erleben zu den Entwicklungsaufgaben zusätzliche Stressoren, wie vermehrte elterliche Konflikte bis hin zur Scheidung, ein krankheitsbedingtes inkonsequentes und dysfunktionales Erziehungsverhalten und eine meist weniger unterstützende Umgebung. Ziel dieser Arbeit ist es, zu überprüfen, ob durch die behaviorale Familienintervention «Triple P» die Erziehungskompetenzen gefördert werden können, sodass sich die psychische Symptomatik, aber auch das kindliche Problemverhalten und das dysfunktionale Erziehungsverhalten verbessern. <b><i>Methodik:</i></b> Die Stichprobe der Pilotstudie setzte sich aus einer Patientengruppe (n = 22) und einer gesunden Vergleichsgruppe (n = 20) zusammen. Eltern- sowie kindbezogene Variablen wurden vor und nach Abschluss der ambulanten Psychotherapie erhoben und mittels Varianzanalyse mit Messwiederholung analysiert. <b><i>Ergebnisse:</i></b> Das dysfunktionale und funktionale Erziehungsverhalten sowie die psychische Befindlichkeit der Eltern und die kindlichen Verhaltensauffälligkeiten aus Elternsicht verbesserten sich signifikant. <b><i>Schlussfolgerungen:</i></b> Die Ergebnisse unterstreichen die Relevanz der Berücksichtigung von Elternschaft und Erziehung in der ambulanten Einzelpsychotherapie, sodass dysfunktionales Erziehungsverhalten und damit auch kindliches und familiäres Problemverhalten verbessert werden können.
DOI: 10.6084/m9.figshare.5129890.v1
title: Supplementary Material for: In-Office Hyaluronate Injection Laryngoplasty as Palliative Treatment for Unilateral Vocal Fold Paralysis

description: <b><i>Background:</i></b> Voice and swallowing impairments can impact on both quality of life and survival. Unilateral vocal fold paralysis (UVFP) as a result of distant metastasis can cause breathy voice and aspiration. The purpose of this study is to develop and evaluate a less invasive and effective alternative therapy for UVFP. <b><i>Methods:</i></b> This was a retrospective review of prospectively enrolled patients at a tertiary referral center in Taiwan. Among a cohort of 177 patients who received intracordal hyaluronate injections, 2 had UVFP from distant metastasis and met the inclusion criteria. Vocal cord motion was recorded by videostroboscopy, and the normalized glottal gap area was measured. Voice quality, defined by speech language pathologists, and swallowing status were compared, and immediate complications after the injection were investigated. <b><i>Results:</i></b> Two patients with UVFP with M1 lesions (both lung) accepted the procedure. The glottal gap area was significantly improved 1 month after in-office hyaluronate injection. Voice quality and aspiration were also improved. No immediate complications were noted in either patient. <b><i>Conclusions:</i></b> In-office intracordal hyaluronate injection is a safe and effective treatment for UVFP, providing a palliative method to help maintain the patient's voice and quality of life.
DOI: 10.6084/m9.figshare.5129896.v1
title: Supplementary Material for: Fissure Integrity and Volume Reduction in Emphysema: A Retrospective Study

description: <b><i>Background:</i></b> One-way endobronchial valves (EBVs) relieve symptoms of emphysema, particularly in patients without collateral ventilation between the target and adjacent lobes. Pretreatment knowledge of fissure integrity could serve as an aid in indicating EBV interventions. <b><i>Objective:</i></b> This study aimed to investigate the relationship between software-measured lung fissure integrity and clinically relevant lung volume reduction (≥350 ml) in emphysema patients treated with one-way EBVs using a lobar exclusion strategy. <b><i>Methods:</i></b> Of 108 patients treated between March 2008 and July 2014, 38 had both baseline and follow-up computed tomography (CT) scans acquired following a specific protocol for quantitative CT analysis and were included in the study (total of 39 treatments, two lungs treated in 1 patient). Outcome measures were fissure integrity measured on baseline CT scans, difference between pre- and postoperative lung volume (considering the lowest measured postoperative volume), and correlation between fissure integrity and volume change. <b><i>Results:</i></b> Fissure integrity ≥75% correlated with volume reduction ≥350 ml (Spearman coefficient: -0.65; p &lt; 0.01). The mean and median volume reductions were 1,223.96 ± 907.5 ml and 663 ml, respectively, for lungs with fissure integrity ≥75% (n = 31). The accuracy of fissure integrity ≥75% in predicting a volume reduction was 87.2%. The positive predictive value of fissure integrity ≥75% to predict a volume reduction ≥350 ml was 83.9%, and it was 70% for fissure integrity 75-90% and 90.5% for fissure integrity &gt;90%. <b><i>Conclusions:</i></b> A target lobe volume reduction using EBVs is possible with lung fissure integrity ≥75%. For patients with fissure integrity between 75 and 90%, a further evaluation of interlobar ventilation should be performed. A clinically relevant volume reduction following treatment with EBVs is likely with any level of fissure integrity &gt;90%.
DOI: 10.6084/m9.figshare.5129887.v1
title: Supplementary Material for: «Nicht von schlechten Eltern!» Effekte einer therapieintegrierten Familienintervention

description: <b><i>Hintergrund:</i></b> Eine psychische Erkrankung bringt viele Belastungen mit sich. Insbesondere die Kinder psychisch kranker Eltern erleben zu den Entwicklungsaufgaben zusätzliche Stressoren, wie vermehrte elterliche Konflikte bis hin zur Scheidung, ein krankheitsbedingtes inkonsequentes und dysfunktionales Erziehungsverhalten und eine meist weniger unterstützende Umgebung. Ziel dieser Arbeit ist es, zu überprüfen, ob durch die behaviorale Familienintervention «Triple P» die Erziehungskompetenzen gefördert werden können, sodass sich die psychische Symptomatik, aber auch das kindliche Problemverhalten und das dysfunktionale Erziehungsverhalten verbessern. <b><i>Methodik:</i></b> Die Stichprobe der Pilotstudie setzte sich aus einer Patientengruppe (n = 22) und einer gesunden Vergleichsgruppe (n = 20) zusammen. Eltern- sowie kindbezogene Variablen wurden vor und nach Abschluss der ambulanten Psychotherapie erhoben und mittels Varianzanalyse mit Messwiederholung analysiert. <b><i>Ergebnisse:</i></b> Das dysfunktionale und funktionale Erziehungsverhalten sowie die psychische Befindlichkeit der Eltern und die kindlichen Verhaltensauffälligkeiten aus Elternsicht verbesserten sich signifikant. <b><i>Schlussfolgerungen:</i></b> Die Ergebnisse unterstreichen die Relevanz der Berücksichtigung von Elternschaft und Erziehung in der ambulanten Einzelpsychotherapie, sodass dysfunktionales Erziehungsverhalten und damit auch kindliches und familiäres Problemverhalten verbessert werden können.
DOI: 10.6084/m9.figshare.5129884.v1
title: Supplementary Material for: Component-Resolved Diagnosis of Peanut Allergy and Its Possible Origins of Sensitization in China

description: <b><i>Background:</i></b> Clinical and immunological characteristics of food allergies vary depending on geographic regions. Little is known about peanut allergy in China. The aim of this study was to investigate the peanut sensitization profile in China. <b><i>Methods:</i></b> Thirty-eight participants with immunoglobulin E (IgE)-positive responses to peanuts (peanut-sensitized) were included in our study, and clinical characteristics were evaluated. Total and specific IgE reactivity against peanuts, other plant-derived foods, pollens, and related allergen components were determined. <b><i>Results:</i></b> Eighteen patients were symptomatic when exposed to peanuts. The majority of them presented with systemic reactions. More than half of the peanut-sensitized subjects also suffered from mugwort pollinosis and peach allergy. In patients with both peanut and peach allergies, reactions to peanuts were the same as or severer than those to peaches. Positivity rates of IgE response to rAra h 1-3, 8, and 9 in the peanut allergy group were 5.6, 11.1, 5.6, 22.2, and 83.3%, respectively. 66.7% (12/18) of the peanut-allergic patients were monosensitized to rAra h 9. Anti-nArt v 3 [mugwort nonspecific lipid transfer protein (nsLTP)] IgE positivity in the peanut allergy group was significantly higher than that in the asymptomatic peanut-sensitized group. In Ara h 9 (peanut nsLTP)-sensitized patients with mugwort pollinosis, anti-nArt v 3 IgE levels were remarkably higher than anti-rAra h 9 (peanut nsLTP) IgE levels as well as anti-Pru p 3 (peach nsLTP) IgE levels. <b><i>Conclusions:</i></b> Ara h 9 was the major allergen of peanut, and Ara h 9 monosensitization was the most common peanut sensitization pattern in our population. Furthermore, there was a strong correlation between peanut sensitization and mugwort pollinosis, as well as peach allergy, in our country.
DOI: 10.6084/m9.figshare.5129869
title: Supplementary Material for: Ranibizumab in Myopic Choroidal Neovascularization: A Subgroup Analysis by Ethnicity, Age, and Ocular Characteristics in RADIANCE

description: <b><i>Purpose:</i></b> To assess the impact of ethnicity, age, and ocular characteristics on ranibizumab efficacy in myopic choroidal neovascularization (CNV). <b><i>Methods:</i></b> In this post hoc subgroup analysis from the phase III RADIANCE study, best-corrected visual acuity (BCVA) outcomes and treatment exposure were analyzed in 105 patients treated with ranibizumab 0.5 mg. Baseline categories included ethnicity, age, baseline BCVA, lesion area, CNV lesion area, refraction sphere, axial length, subretinal fluid, and location of CNV. <b><i>Results:</i></b> At month 12, the mean change in BCVA was numerically higher in East-Asians than in Caucasians (17.0 vs. 14.1 letters). The median number of injections varied with ethnicity (East-Asians vs. Caucasians: 2 vs. 3), baseline BCVA (highest vs. lowest: 1 vs. 4), CNV lesion area and lesion area (largest vs. smallest: 5 vs. 1 and 5 vs. 2). <b><i>Conclusions:</i></b> East-Asians showed numerically higher BCVA gains than Caucasians. The number of injections varied across subgroups, emphasizing the need for individualized treatment.
DOI: 10.6084/m9.figshare.5129872
title: Supplementary Material for: Cross-Sectional Guidelines for Therapy with Blood Components and Plasma Derivatives: Chapter 5 Human Albumin - Revised

description: Chapter 5 ‘Human Albumin' that was suspended on January 10, 2011 has been completed and updated in the present version.
DOI: 10.6084/m9.figshare.5129875
title: Supplementary Material for: Differential Expression of Stem Cell Markers in Human Adamantinomatous Craniopharyngioma and Pituitary Adenoma

description: <b><i>Background/Aims:</i></b> Although craniopharyngioma (CP) is histologically benign, it is a pituitary tumour that grows rapidly and often recurs. Adamantinomatous CP (ACP) was associated with an activating mutation in β-catenin, and it has been postulated that pituitary stem cells might play a role in oncogenesis in human ACP. Stem cells have also been identified in pituitary adenoma. Our aim was to characterize the expression pattern of <i>ABCG2</i>, <i>CD44, DLL4, NANOG, NOTCH2, POU5F1/OCT4, SOX2, </i>and <i>SOX9</i> stem cell markers in human ACP and pituitary adenoma. <b><i>Methods and Results:</i></b> We studied 33 patients (9 ACP and 24 adenoma) using real-time quantitative PCR (RT-qPCR) and immunohistochemistry. <i>SOX9 </i>was up-regulated in ACP, exhibiting positive immunostaining in the epithelium and stroma, with the highest expression in patients with recurrence. <i>CD44</i> was overexpressed in ACP as confirmed by immunohistochemistry. <i>SOX2</i> did not significantly differ among the tumour types. The RT-qPCR array showed an increased expression of <i>MKI67,</i><i>OCT4</i>/<i>POU5F1,</i> and <i>DLL4 </i>in all tumours. <i>NANOG </i>was decreased in ACP. <i>ABCG2</i> was down-regulated in most of the tumours. <i>NOTCH2 </i>was significantly decreased in the adenomas. <b><i>Conclusion:</i></b> Our results confirm the presence of stem cell markers in human pituitary tumours as well as the different expression patterns of ACP and adenoma. These findings suggest that ACP may originate from a more undifferentiated cell cluster. Additionally, <i>SOX9</i> immunodetection in the stroma and the highest expression levels related to the relapse of patients suggest a contribution to the aggressive behaviour and high recurrence of this tumour type.
DOI: 10.6084/m9.figshare.5129878
title: Supplementary Material for: Diagnosis of Severe Fetomaternal Hemorrhage with Fetal Cerebral Doppler: Case Series and Systematic Review

description: <b><i>Objectives:</i></b> To analyze the role of middle cerebral artery (MCA) peak systolic velocity (PSV) in the prediction of severe fetomaternal hemorrhage (FMH) and to compare it with standard biophysical assessment. <b><i>Data Sources:</i></b> Retrospective review of cases of FMH seen in our unit and systematic review of the literature. <b><i>Results:</i></b> We followed the MOOSE guidelines to review the literature. From 838 articles, 16 were selected. In total, 35 women, including 3 cases from our center and 32 obtained from the literature search were included. Diagnosis of FMH was always confirmed by laboratory tests. Patients were seen at 31 ± 5 weeks' gestation (range 16-39) and the most frequent indication for referral was decreased perception of fetal movements. Cardiotocography (CTG) upon admission was sinusoidal in 18 cases, nonreactive in 6, decelerative in 2 and tachycardic in one. MCA-PSV was abnormal in all cases but one. There were 2 perinatal deaths. The mean hemoglobin concentration at birth or at intrauterine transfusion was 4.8 ± 1.9 g/dl. <b><i>Discussion:</i></b> The most accurate predictor of FMH was fetal MCA-PSV. CTG was always abnormal but the pattern was frequently nonspecific. We suggest including fetal cerebral Doppler in the evaluation of patients with decreased fetal movements, particularly in those cases with ambiguous results of biophysical testing.
DOI: 10.6084/m9.figshare.5129866
title: Supplementary Material for: Novel Genetic Loci Associated with the Plasma Triglyceride Response to an Omega-3 Fatty Acid Supplementation

description: <b><i>Background:</i></b> A recent genome-wide association study (GWAS) by our group identified 13 loci associated with the plasma triglyceride (TG) response to omega-3 (n-3) fatty acid (FA) supplementation. This study aimed to test whether single-nucleotide polymorphisms (SNPs) within the <i>IQCJ, NXPH1, PHF17</i> and <i>MYB</i> genes are associated with the plasma TG response to an n-3 FA supplementation. <b><i>Methods:</i></b> A total of 208 subjects followed a 6-week n-3 FA supplementation of 5 g/day of fish oil (1.9-2.2 g of eicosapentaenoic acid and 1.1 g of docosahexaenoic acid). Measurements of plasma lipids were made before and after the supplementation. Sixty-seven tagged SNPs were selected to increase the density of markers near GWAS hits. <b><i>Results:</i></b> In a repeated model, independent effects of the genotype and the gene-supplementation interaction were associated with plasma TG. Genotype effects were observed with two SNPs of <i>NXPH1</i>, and gene-diet interactions were observed with ten SNPs of <i>IQCJ</i>, four SNPs of <i>NXPH1</i> and three SNPs of <i>MYB</i>. Positive and negative responders showed different genotype frequencies with nine SNPs of <i>IQCJ</i>, two SNPs of <i>NXPH1</i> and two SNPs of <i>MYB</i>. <b><i>Conclusion:</i></b> Fine mapping in GWAS-associated loci allowed the identification of SNPs partly explaining the large interindividual variability observed in plasma TG levels in response to an n-3 FA supplementation.
DOI: 10.6084/m9.figshare.5129872.v1
title: Supplementary Material for: Cross-Sectional Guidelines for Therapy with Blood Components and Plasma Derivatives: Chapter 5 Human Albumin - Revised

description: Chapter 5 ‘Human Albumin' that was suspended on January 10, 2011 has been completed and updated in the present version.