cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.3535/aeg-z7j-z0t
title: Gramineae Juss.

description: Digital Specimen for the physical specimen hosted at Natural History Museum Vienna.
DOI: 10.15468/dl.eek3bz
title: Occurrence Download

description: A dataset containing 135 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Silene antirrhina",
 "Country is Argentina",
 "HasCoordinate is true"
 ]
}

 The dataset includes 135 records from 15 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0025016-250711103210423/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.mrzdjx
title: Occurrence Download

description: A dataset containing 25 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Elodea nuttallii",
 "Country is Poland",
 "HasCoordinate is true"
 ]
}

 The dataset includes 25 records from 2 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0025017-250711103210423/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.2kr27a
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Elodea nuttallii",
 "Country is Serbia",
 "HasCoordinate is true"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0025018-250711103210423/datasets/export for details.
DOI: 10.15468/dl.pvra23
title: Occurrence Download

description: A dataset containing 33 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Draba dolomitica"
 ]
}

 The dataset includes 33 records from 6 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0025019-250711103210423/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.6084/m9.figshare.25101515
title: A comprehensive integrated gene network construction to explore the essential role of Notch 1 in lung adenocarcinoma (LUAD)

description: The heterogeneous biological landscape of non-small cell lung cancer (NSCLC) is largely attributed to the activation of Notch signalling pathway. Among the Notch family transmembrane proteins, neurogenic locus notch homolog protein1 (NOTCH1) is a putative oncogene in NSCLC which activates the pathway as negative prognostic factor. This study aims to explore integrated network approach in lung adenocarcinoma (LUAD) especially linked to the notch pathway and its receptors. Our gene set enrichment analysis reveals the key Notch pathway genes are predominantly down regulated in LUAD. There were 675 genes with a total of 6517 functional interactions and 6 densely connected clusters of 38 miRNAs, 84 transcription factors with 156 edges identified through network construction. Here we report five key genes namely NOTCH1, CDH1, ERBB2, GAPDH and COL1A1 significantly enriched in Notch pathway which are further validated through the KM plot, box plots, stage plots and TIMER analysis. In addition, the NOTCH1 receptor is strongly linked to the immune checkpoint inhibitor CD274 (PD-L1) and can be considered as prognostic marker and tumour suppressor gene in LUAD which surely provide the basis for early diagnosis and futuristic immunotherapeutic targets for LUAD.
DOI: 10.6084/m9.figshare.25101515.v1
title: A comprehensive integrated gene network construction to explore the essential role of Notch 1 in lung adenocarcinoma (LUAD)

description: The heterogeneous biological landscape of non-small cell lung cancer (NSCLC) is largely attributed to the activation of Notch signalling pathway. Among the Notch family transmembrane proteins, neurogenic locus notch homolog protein1 (NOTCH1) is a putative oncogene in NSCLC which activates the pathway as negative prognostic factor. This study aims to explore integrated network approach in lung adenocarcinoma (LUAD) especially linked to the notch pathway and its receptors. Our gene set enrichment analysis reveals the key Notch pathway genes are predominantly down regulated in LUAD. There were 675 genes with a total of 6517 functional interactions and 6 densely connected clusters of 38 miRNAs, 84 transcription factors with 156 edges identified through network construction. Here we report five key genes namely NOTCH1, CDH1, ERBB2, GAPDH and COL1A1 significantly enriched in Notch pathway which are further validated through the KM plot, box plots, stage plots and TIMER analysis. In addition, the NOTCH1 receptor is strongly linked to the immune checkpoint inhibitor CD274 (PD-L1) and can be considered as prognostic marker and tumour suppressor gene in LUAD which surely provide the basis for early diagnosis and futuristic immunotherapeutic targets for LUAD.
DOI: 10.6084/m9.figshare.24874273
title: Comprehending interaction mechanism of natural actives of <i>Colchicum autumnale</i> L. for rheumatoid arthritis using integrative chemoinformatic approaches

description: This research delves into the realm of therapeutic potential within natural compounds derived from <i>Colchicum autumnale</i> L., emphasizing a holistic perspective on medications used in human therapy. Rather than confining the study to their primary actions, the research endeavors to unveil molecular targets for these natural compounds, with a specific focus on their potential applicability in the treatment of rheumatoid arthritis (RA). The study focuses on understanding interactions between specific natural actives that target RA. Fifteen RA target proteins were identified from OMIM, GeneScan and PharmaGKB. Their structures were downloaded from RCSB PDB. Two active components of <i>C. autumnale</i> L. were chosen for mass spectrometry investigation. Ligand characteristics were determined using the ADMETlab and SwissADME software tools. Molecular docking was performed, and the top three complexes were simulated for 200 ns, along with identification of free binding energies. The compounds β-sitosterol–IL-10 (−6.50 kcal/mol), colchicine–IL-10 (−6.01 kcal/mol), linoleic acid–IL-10 (−7.22 kcal/mol) and linoleic acid–IL-10 (−7.22 kcal/mol) exhibited best binding energies. β-Sitosterol and colchicine showed the highest stability in simulations, confirmed by molecular mechanics free energy binding calculations. This work provides insights into the molecular interaction of natural compounds against RA targets, offering potential therapeutic anti-RA medications.
DOI: 10.6084/m9.figshare.24874273.v1
title: Comprehending interaction mechanism of natural actives of <i>Colchicum autumnale</i> L. for rheumatoid arthritis using integrative chemoinformatic approaches

description: This research delves into the realm of therapeutic potential within natural compounds derived from <i>Colchicum autumnale</i> L., emphasizing a holistic perspective on medications used in human therapy. Rather than confining the study to their primary actions, the research endeavors to unveil molecular targets for these natural compounds, with a specific focus on their potential applicability in the treatment of rheumatoid arthritis (RA). The study focuses on understanding interactions between specific natural actives that target RA. Fifteen RA target proteins were identified from OMIM, GeneScan and PharmaGKB. Their structures were downloaded from RCSB PDB. Two active components of <i>C. autumnale</i> L. were chosen for mass spectrometry investigation. Ligand characteristics were determined using the ADMETlab and SwissADME software tools. Molecular docking was performed, and the top three complexes were simulated for 200 ns, along with identification of free binding energies. The compounds β-sitosterol–IL-10 (−6.50 kcal/mol), colchicine–IL-10 (−6.01 kcal/mol), linoleic acid–IL-10 (−7.22 kcal/mol) and linoleic acid–IL-10 (−7.22 kcal/mol) exhibited best binding energies. β-Sitosterol and colchicine showed the highest stability in simulations, confirmed by molecular mechanics free energy binding calculations. This work provides insights into the molecular interaction of natural compounds against RA targets, offering potential therapeutic anti-RA medications.
DOI: 10.6084/m9.figshare.25107949
title: <i>In silico</i> screening of phytoconstituents as potential anti-inflammatory agents targeting NF-κB p65: an approach to promote burn wound healing

description: Chronic burn wounds are frequently characterised by a prolonged and dysregulated inflammatory phase that is mediated by over-activation of NF-κB p65. Synthetic wound healing drugs used for treatment of inflammation are primarily associated with several shortcomings which reduce their therapeutic index. In this scenario, phytoconstituents that exhibit multifaceted biological activities including anti-inflammatory effects have emerged as a promising therapeutic alternative. However, identification and isolation of phytoconstituents from medicinal herbs is a cumbersome method that is linked to profound uncertainty. Hence, present study aimed to identify prospective phytoconstituents as inhibitors of RHD of NF-κB p65 by utilizing <i>in silico</i> approach. Virtual screening of 2821 phytoconstituents was performed against protein model. Out of 2821 phytoconstituents, 162 phytoconstituents displayed a higher binding affinity (≤ −8.0 kcal/mol). These 162 phytoconstituents were subjected to ADMET predictions, and 15 of them were found to satisfy Lipinski’s rule of five and showed favorable pharmacokinetic properties. Among these 15 phytoconstituents, 5 phytoconstituents with high docking scores i.e. silibinin, bismurrayaquinone A, withafastuosin B, yuccagenin, (+)-catechin 3-gallate were selected for molecular dynamics (MD) simulation analysis. Results of MD simulation indicated that withafastuosin B, (+)-catechin 3-gallate and yuccagenin produced a compact and stable complex with protein without significant variations in conformation. Relative binding energy analysis of best hit molecules indicate that withafastuosin B, and (+)-catechin 3-gallate exhibit high binding affinity with target protein among other lead molecules. Findings of study suggest that these phytoconstituents could serve as promising anti-inflammatory agents for treatment of burn wounds by inhibiting the RHD of NF-κB p65.
DOI: 10.6084/m9.figshare.25107949.v1
title: <i>In silico</i> screening of phytoconstituents as potential anti-inflammatory agents targeting NF-κB p65: an approach to promote burn wound healing

description: Chronic burn wounds are frequently characterised by a prolonged and dysregulated inflammatory phase that is mediated by over-activation of NF-κB p65. Synthetic wound healing drugs used for treatment of inflammation are primarily associated with several shortcomings which reduce their therapeutic index. In this scenario, phytoconstituents that exhibit multifaceted biological activities including anti-inflammatory effects have emerged as a promising therapeutic alternative. However, identification and isolation of phytoconstituents from medicinal herbs is a cumbersome method that is linked to profound uncertainty. Hence, present study aimed to identify prospective phytoconstituents as inhibitors of RHD of NF-κB p65 by utilizing <i>in silico</i> approach. Virtual screening of 2821 phytoconstituents was performed against protein model. Out of 2821 phytoconstituents, 162 phytoconstituents displayed a higher binding affinity (≤ −8.0 kcal/mol). These 162 phytoconstituents were subjected to ADMET predictions, and 15 of them were found to satisfy Lipinski’s rule of five and showed favorable pharmacokinetic properties. Among these 15 phytoconstituents, 5 phytoconstituents with high docking scores i.e. silibinin, bismurrayaquinone A, withafastuosin B, yuccagenin, (+)-catechin 3-gallate were selected for molecular dynamics (MD) simulation analysis. Results of MD simulation indicated that withafastuosin B, (+)-catechin 3-gallate and yuccagenin produced a compact and stable complex with protein without significant variations in conformation. Relative binding energy analysis of best hit molecules indicate that withafastuosin B, and (+)-catechin 3-gallate exhibit high binding affinity with target protein among other lead molecules. Findings of study suggest that these phytoconstituents could serve as promising anti-inflammatory agents for treatment of burn wounds by inhibiting the RHD of NF-κB p65.
DOI: 10.15468/2z65na
title: Herbarium specimens of the genus Uromyces (Link) Unger preserved in the mycological herbarium collection - TASM

description: Uromyces acantholimonis Syd.-8
Uromyces acetosae J. Schröt.-1
Uromyces alhagi Szemb -2
Uromyces anthyllidis (Grev.) J. Schröt-3
Uromyces arenariae Tranzschel -4
Uromyces astragali-lasiosemi Vienn.-Bourg.-1
Uromyces chenopodii J. Schröt.-8
Uromyces dactylidis G.H. Otth-1
Uromyces dianthi (Pers.) Niessl-1
Uromyces excavatus (DC.) Magnus -1
Uromyces fallens (Desm.) Barthol.-12
Uromyces geranii (DC.) G.H. Otth & Wartm.-2
Uromyces glycyrrhizae (Rabenh.) Magnus-37
Uromyces graminis (Niessl) Dietel -1
Uromyces hedysari-obscuri (DC.) Carestia & Picc.-3
Uromyces heimerlianus Magnus-1
Uromyces inaequialtus Lasch -2
Uromyces junci Tul., Ann.-1
Uromyces lapponicus Lagerh.-2
Uromyces limonii (DC.) Lév. -10
Uromyces lineolatus (Desm.) J. Schröt.-3
Uromyces magnusii Kleb. -1
Uromyces minor J. Schröt.-1
Uromyces mogianensis Bubák-1
Uromyces muscari (Duby) Niessl-4
Uromyces nerviphilus (Grognot) Hotson-8
Uromyces phyteumatum (DC.) Fr.-1
Uromyces pisi-sativi (Pers.)-16
Uromyces polygoni-avicularis (Pers.) G.H. Otth-2
Uromyces salsolae Rabenh., Hedwigia-19
Uromyces scrophulariae (DC.) Fuckel-2
Uromyces scutellatus (Schrank) Lév. -2
Uromyces sp.-2
Uromyces striatus J. Schröt.-28
Uromyces trifolii-repentis (Castagne) Liro-14
Uromyces tuberculatus (Fuckel) Fuckel-2
Uromyces verruculosus J. Schröt.-1
Uromyces vesicatorius (Bubák) Nattrass-1
Uromyces viciae-craccae Const.-3
Uromyces viciae-fabae (Pers.) J. Schröt.-2
DOI: 10.6084/m9.figshare.29585900
title: Boosting Employer Brand Image Through Sustainability Driven Managerial Approach: Moderator Effect of Person-Organization Fit.

description: Quantative data for the article Boosting Employer Brand Image Through Sustainability Driven Managerial Approach: Moderator Effect of Person-Organization Fit.<br><br>
DOI: 10.6084/m9.figshare.29585900.v1
title: Boosting Employer Brand Image Through Sustainability Driven Managerial Approach: Moderator Effect of Person-Organization Fit.

description: Quantative data for the article Boosting Employer Brand Image Through Sustainability Driven Managerial Approach: Moderator Effect of Person-Organization Fit.<br><br>
DOI: 10.15468/dl.at2kvp
title: Occurrence Download

description: A dataset containing 631 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Gonichthys tenuiculus"
 ]
}

 The dataset includes 631 records from 27 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0025020-250711103210423/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.q3thzj
title: Occurrence Download

description: A dataset containing 3 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Oreochromis macrochir macrochir"
 ]
}

 The dataset includes 3 records from 3 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0025021-250711103210423/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.3535/bd6-8dm-s92
title: Gramineae Juss.

description: Digital Specimen for the physical specimen hosted at Natural History Museum Vienna.
DOI: 10.15468/dl.6axdwh
title: Occurrence Download

description: A dataset containing 53 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Farsetia latifolia"
 ]
}

 The dataset includes 53 records from 4 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0025023-250711103210423/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.w3uaaf
title: Occurrence Download

description: A dataset containing 472 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Baptisia australis minor)",
 "HasCoordinate is true",
 "HasGeospatialIssue is false"
 ]
}

 The dataset includes 472 records from 29 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0025022-250711103210423/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.qr52bu
title: Occurrence Download

description: A dataset containing 53 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Erysimum deflexum"
 ]
}

 The dataset includes 53 records from 12 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0025024-250711103210423/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.cqw7tf
title: Occurrence Download

description: A dataset containing 13033 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Brassica tournefortii",
 "Country is Australia",
 "HasCoordinate is true"
 ]
}

 The dataset includes 13033 records from 41 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0025025-250711103210423/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.jtzj9q
title: Occurrence Download

description: A dataset containing 31 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Silene antirrhina",
 "Country is Brazil",
 "HasCoordinate is true"
 ]
}

 The dataset includes 31 records from 16 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0025026-250711103210423/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.nefc5e
title: Occurrence Download

description: A dataset containing 39 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Elodea nuttallii",
 "Country is Slovakia",
 "HasCoordinate is true"
 ]
}

 The dataset includes 39 records from 3 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0025027-250711103210423/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.hgxq59
title: Occurrence Download

description: A dataset containing 4 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Sarotherodon macrochir"
 ]
}

 The dataset includes 4 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0025028-250711103210423/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.j22bxy
title: Occurrence Download

description: A dataset containing 5743950 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is Colombia",
 "OccurrenceStatus is Present",
 "TaxonKey is Plantae"
 ]
}

 The dataset includes 5743950 records from 1655 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0024997-250711103210423/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.3535/4yx-z2j-y6q
title: Brachiopoda Duméril, 1805

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/mvq-xcm-ah6
title: Equus (Equus) caballus Linnaeus, 1758

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/d2r-cm6-f32
title: Chondrichthyes

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/wxb-nxh-775
title: Squalus acanthias Linnaeus, 1758

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/w1v-bpz-e0q
title: Raja

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/de9-4cs-t8n
title: Balclutha Kirkaldy, 1900

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/zje-pvr-lev
title: Mammalia Linnaeus, 1758

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/qs3-1j9-rx9
title: Cetacea Brisson, 1762

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/16c-lah-w5p
title: †Palorbitolina lenticularis (Blumenbach, 1805)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/9vz-pt7-xj6
title: Animalia

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/jyv-zzl-kdx
title: Cnidaria

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/st2-28n-r3g
title: †Amphitryon murchisonii Hawle & Corda, 1847

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/2sd-p3y-jav
title: †Palorbitolina lenticularis (Blumenbach, 1805)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/rw1-c2v-8ed
title: Balclutha Kirkaldy, 1900

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/w0p-zw0-kac
title: Phacops

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/zsm-552-fb2
title: Graptolithina Bronn, 1849

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/6ml-5nz-yby
title: Chondrichthyes

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/zkn-kez-lew
title: Pseudorotalia schroeteriana (Parker & Jones in Carpenter, 1862)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/l9p-a80-6ks
title: †Cymbalopora radiata Hagenow, 1851

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/5nv-k8y-bhf
title: Brachiopoda Duméril, 1805

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/6wd-1n6-a3c
title: Brachiopoda Duméril, 1805

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/1mv-pna-l50
title: Crinoidea Miller, 1821

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/9wk-v2r-rwg
title: Sus scrofa Linnaeus, 1758

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/x1v-x9q-ssh
title: Bryozoa

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/e9g-btd-chj
title: Cetacea Brisson, 1762

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/r88-4p8-gvs
title: †Kloucekia phillipsii (Barrande, 1846)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/ngy-g9q-3l9
title: †Assilina granulosa (d'Archiac, 1850)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/s1f-ngr-r44
title: †Palorbitolina lenticularis (Blumenbach, 1805)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.