cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.28872962.v1
title: Data and code from: Flow direction matters: hatchery-reared coho salmon (<i>Oncorhynchus kisutch</i>) develop less otolith deformities in tanks with alternating water flow directions

description: Data and code from the manuscript: "Flow direction matters: hatchery-reared coho salmon (<i>Oncorhynchus kisutch</i>) develop less otolith deformities in tanks with alternating water flow directions"This Figshare repository includes all raw data and code used in the manuscript, organized as follows:Otolith Examination:<b>flow.csv</b><br>Contains raw data on the percent coverage of aragonite and vaterite for the left (L) and right (R) sagittal otoliths of individual coho salmon from each treatment (alternating, clockwise, counterclockwise) and tank across two experimental years.<b>flow.pond.release.csv</b><br>A subset of flow.csv including only data for fish sampled at first ponding (experiment day 0) and at release (experiment day ~400) for each treatment.In both datasets:"percent.arag.L" and "percent.vat.L" refer to the percentage of aragonite and vaterite pixels in the left otolith, respectively."percent.arag.R" and "percent.vat.R" refer to the percentage of aragonite and vaterite pixels in the right otolith, respectively.Measurements were generated by manually classifying otolith regions in Adobe Photoshop and calculating pixel coverage using a Python script.Representative otolith images and details of the classification workflow are provided in the main manuscript figures and Methods section. The full image dataset is available from the corresponding author upon reasonable request, but is not required to reproduce the analyses.<b>FlowTrialsStats.Rmd</b> and <b>FlowTrialsStats.pdf</b><br>Contain all R code and output used to analyze vaterite coverage and otolith pair type proportions over time using zero-inflated beta GLMMs and other methods described in the manuscript.Survival Analyses:<b>bottleneck_locations_2024-01-09.xlsx</b><br>Provides latitude and longitude coordinates for the PIT-tag antenna arrays installed in the Goldstream River.<b>goldstream_detections_2024-11-15.csv</b><br>Contains PIT-tag detection records for juvenile and returning adult coho salmon, including timestamps, PIT tag IDs, and detection array IDs.<b>Goldstream coho_Detection_Efficiency.R</b><br>R code for calculating PIT antenna detection efficiencies following the method of Connolly (2010), incorporating Wilson’s 95% confidence intervals.<b>Goldstream coho_SAR analyses.R</b><br>R code for estimating survival to adult return (SAR) rates adjusted for detection efficiencies and for conducting logistic regression analyses on individual PIT-tag survival outcomes.
DOI: 10.6084/m9.figshare.16715611.v1
title: Supplementary Material for: Patterns of Use and Clinical Outcomes with Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Blockers in Acute Heart Failure and Changes in Kidney Function: An Analysis of the Veterans’ Health Administrative Database

description: <b><i>Objective:</i></b> The aim of the study was to determine patterns and predictors of utilization of angiotensin-converting enzyme inhibitors/angiotensin receptor blockers (ACEI/ARBs) in patients with acute heart failure (AHF) and changes in kidney function at admission, hospitalization, and discharge in relation to clinical outcomes. <b><i>Methods:</i></b> This retrospective analysis of the Veterans’ Health Administration data (2016) included patients with heart failure (HF) with reduced ejection fraction who were hospitalized. Patients with an estimated glomerular filtration &lt;15 cm<sup>3</sup>/min/1.73 m<sup>2</sup> and those on dialysis were excluded. Patients were categorized based on the use of ACEI/ARB as continued, initiated, discontinued, or no therapy. Multivariable logistic regression evaluated predictors of being discharged home on an ACEI/ARB. Cox regression analysis evaluated outcomes (30 and 180-day mortality/HF readmissions). <b><i>Results:</i></b> 3,652 patients were included, of which 37% of patients hospitalized for AHF had ACEI/ARB discontinued on admission, or not initiated. After adjusting for age, blood pressure, and serum potassium, a per-unit increase in admission serum creatinine (SCr) was independently associated with lower rates of continuation or initiation of ACEI/ARB odds ratio 0.51 95% confidence interval (CI) (0.46–0.57). Discharge on ACEI/ARB was independently associated with lower odds of 30- and 180-day mortality hazard ratio (HR) 0.36 95% CI (0.25–0.52), and HR 0.23 95% CI (0.19–0.27), respectively. <b><i>Conclusion:</i></b> Higher SCr at admission is an important determinant of ACEI/ARB being discontinued or withheld in patients admitted with AHF. ACEI/ARB at discharge was associated with lower mortality in patients with AHF.
DOI: 10.6084/m9.figshare.23978442.v1
title: Supplementary Material for: Depression and anxiety trajectories in chronic disease: a systematic review and meta-analysis

description: Introduction: People living with chronic diseases are at increased risk of anxiety and depression, which are associated with poorer medical and psychosocial outcomes. Many studies have examined the trajectories of depression and anxiety in people with specific diseases, including the predictors of these trajectories. This is valuable for understanding the process of adjustment to disease and informing treatment planning. However, no review has yet synthesised this information across chronic diseases. Methods: Electronic databases were searched for studies reporting trajectories of depression or anxiety in chronic disease samples. Data extracted included sample characteristics, results from trajectory analyses, and predictors of trajectories. Meta-analysis of the overall pooled prevalence of depression and anxiety trajectories was conducted, and qualitative synthesis of disease severity predictors undertaken. Results: Following search and screening, 67 studies were included (N = 61,201 participants). Most participants followed a stable non-clinical trajectory for depression (69.0%, [95% CI 65.6, 72.2] and anxiety (73.4% [95% CI 66.3, 79.5]). Smaller but meaningful subsamples followed a trajectory of depression and anxiety symptoms consistently in the clinical range (11.8% [95% CI 9.2, 14.8], and 13.7% [95% CI 9.3, 19.7] respectively). Several clinical and methodological moderators emerged, and qualitative synthesis suggested that few aspects of disease severity were associated with participants’ trajectories. Discussion: Most people with chronic disease follow a trajectory of distress that is low and stable, suggesting that most people psychologically adjust to living with chronic disease. Evidence also suggests that the nature and severity of disease is not a meaningful predictor of psychological distress.
DOI: 10.6084/m9.figshare.28077017.v1
title: Supplementary Material for: Eligibility for rapid up-titration of guideline-directed medical therapy of real-world patients hospitalised for heart failure

description: Introduction and aims: The 2023 Focused Update of the 2021 ESC Heart Failure (HF) Guidelines recommends the rapid up-titration (RT) of guideline-directed medical therapy (GDMT) for all patients hospitalised for HF to improve prognosis in light of STRONG-HF trial. However, the real-world feasibility of RT and the optimal selection of suitable patients may cause difficulties, as the STRONG-HF trial applied strict randomisation criteria. We aimed to assess the proportion of hospitalised HF patients suitable for RT after discharge.

Methods: The proportion of patients eligible for RT based on the basic in- and exclusion criteria of the STRONG-HF trial (systolic blood pressure [SBP]≥100mmHg, heart rate [HR]≥60min-1, serum potassium≤5mmol/L, eGFR≥30mL/min/1.73m2, discharge NT-proBNP&gt;1500pg/mL) was assessed in a consecutive patient cohort at a tertiary referral center between 01/04/2021 and 31/12/2023. 

Results: Data from 408 consecutive patients were analysed (male: 71%; age: 62[51-72]years; left ventricular ejection fraction: 27[20-35]%; HFrEF: 82%; hypertension: 67%; diabetes: 36%; atrial fibrillation: 47%). 78% of the patients were suitable for RT based on the SBP criterion, 93% on HR, 89% on serum potassium, and 91% on eGFR values. Thus, 60% were eligible for RT using the combined assessment of these parameters. When including the NT-proBNP value as well (60%), 34% of the cohort were eligible for RT.

Conclusions: Based on our study, the proportion of patients suitable for RT of GDMT ranged from 34% to 60% based on the basic eligibility indicators of the STRONG-HF trial. Our results highlight the strategic importance of careful selection of patients eligible for RT.
DOI: 10.15468/dl.rwcvqb
title: Occurrence Download

description: A dataset containing 2188 species occurrences available in GBIF matching the query:
{
 "and" : [
 "HasGeospatialIssue is false",
 "HasCoordinate is true",
 "OccurrenceStatus is Present",
 {
 "not" : {
 "BasisOfRecord" : [
 "is one of (Observation, Human Observation, Machine Observation, Living Specimen)"
 ]
 }
 },
 "TaxonKey is Calendula officinalis L."
 ]
}

 The dataset includes 2188 records from 267 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0009599-250426092105405/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.6084/m9.figshare.8088506.v2
title: GraphEM.nc

description: GraphEM reconstruction netcdf file.<br>
DOI: 10.6084/m9.figshare.25668936.v1
title: Data used for the simulation of impact of morphology of porous media

description: This repository contains simulation cases conducted using OpenFOAM 5.x on a range of digital rocks. These cases are publicly accessible to researchers, providing all simulation results in the form of Excel datasets, plots, and codes for different scenarios.We hope that this repository will be a valuable resource for researchers, professors, and students alike.Mohammad Ghodsi Institute of Petroleum Engineering, University of Tehran
DOI: 10.6084/m9.figshare.8143094.v3
title: Reconstruction ensemble median and 95% range

description: This file contains the the median and 95% range (2.5th and 97.5th percentiles) of the full 7000-member ensemble accross all methods of the PAGES2k Consortium 2019 global mean temperature reconstructions.<br>We strongly recommend working with the full ensemble provided in the other files in this data compilation for a more robust analysis of GMST.The columns in this table are: Year CE, raw instrumental target data, reconstruction ensemble 50th, 2.5th and 97.5th percentiles, 31-year butterworth filtered instrumental target data, 31-year butterworth filtered reconstruction 50th, 2.5th and 97.5th percentilesAll values are °C wrt 1961-1990 over the May-April annual average.
DOI: 10.6084/m9.figshare.28845020.v1
title: some docker

description: some docker
DOI: 10.6084/m9.figshare.3547266.v1
title: Appendix A. Estimating the intrinsic bias in the correlation between cause-specific mortalities: Incorporating experts' opinions using a hierarchical model.

description: Estimating the intrinsic bias in the correlation between cause-specific mortalities: Incorporating experts' opinions using a hierarchical model.
DOI: 10.6084/m9.figshare.12921974.v1
title: The effect of intra-urban mobility flows on the spatial heterogeneity of social media activity: investigating the response to rainfall events

description: Data and codes used to support the research article entitled "The effect of intra-urban mobility flows on the spatial heterogeneity of social media activity: investigating the response to rainfall events", which was submitted to the International Journal of Geographical Information Science.
DOI: 10.6084/m9.figshare.8797190.v3
title: Dataset 4

description: The qRT-PCR validation data of <i>M. oryzae</i> and <i>O. sativa </i>transcriptome
DOI: 10.6084/m9.figshare.10116704.v1
title: OUTPUT Statistic Isoflavon TGF.docx

description: Statistic output of one way Anova TGF beta 1
DOI: 10.6084/m9.figshare.23508312.v1
title: Supplementary Material for: A New Cycler for Automated Peritoneal Dialysis to Provide Efficient Dialysis and Improved Sleep Quality

description: <b><i>Introduction:</i></b> Automated peritoneal dialysis (APD) employs cyclers to control inflow and outflow of the dialysis fluid to the patient’s abdomen. To allow more patients to use this modality, cyclers should support the achievement of an adequate dialysis dose and be easy to use, cost-effective, and silent. The new SILENCIA cycler (Fresenius Medical Care, Bad Homburg, Germany), designed to improve these characteristics in comparison to its predecessor device, was evaluated in this respect in a prospective study. <b><i>Methods:</i></b> This cross-over study comprised two 2-week study periods, separated by a 3-week training phase. First, patients underwent APD with their current cycler (PD-NIGHT [Fresenius Medical Care, Bad Homburg, Germany] or HomeChoice Pro [Baxter, Deerfield, IL, USA] as control), followed by training on the SILENCIA cycler. Then, patients were switched to the SILENCIA cycler. During each treatment period, we collected data on total Kt/Vurea, ultrafiltration (UF) volume, patient-reported outcomes (sleep quality, among others), and device handling. <b><i>Results:</i></b> Sixteen patients were enrolled; 2 patients terminated the study prematurely before study intervention, 1 patient due to a protocol violation. In 13 patients, total Kt/Vurea and UF could be evaluated. Neither Kt/Vurea nor UF differed significantly between control and SILENCIA cyclers. Out of 10 patients answering the questionnaire on sleep quality after the 2-week phase with the SILENCIA cycler, sleep quality improved in 5 patients; in the other patients, sleep quality was rated unchanged compared to the previously used cycler. The average reported sleep time was 5.9 ± 1.8 h with the PD-NIGHT, 7.2 ± 2.1 h with HomeChoice Pro, and 8.0 ± 1.6 h with the SILENCIA cycler. All patients were much or very much satisfied with the new cycler. <b><i>Conclusion:</i></b> The SILENCIA cycler delivers adequate urea clearance and UF. Importantly, sleep quality improved, possibly related to less caution messages and alarms.
DOI: 10.6084/m9.figshare.28022315.v1
title: Supplementary Material for: Outcome after Intraoperative Ejection of DMEK Graft: A Case Report

description: Purpose: There is no data on management of intraoperative ejection of a Descemet membrane endothelial keratoplasty (DMEK) graft. We report a case of graft survival after intraoperative ejection with long term endothelial cell counts and vision.
Case Presentation: A 64-year-old woman with Fuchs corneal dystrophy underwent DMEK in the right eye, during which the graft was completed ejected from the eye, and then recovered and reinjected successfully. She subsequently also underwent DMEK in the left eye without complication. The patient had recovery of vision in both eyes to 20/20 shortly after each surgery. There was much greater loss of endothelial cells in the eye which experienced graft ejection than the eye with routine DMEK surgery (79% vs 44%).
Conclusions: Our results support attempt to recover ejected DMEK graft if conditions are appropriate, but also show that there will be increased loss of endothelial cells as compared to routine surgery.
DOI: 10.6084/m9.figshare.28055171.v1
title: Table 1. Questions & Dimensions - Interview

description: Media Literacy strategies and disability
DOI: 10.6084/m9.figshare.17260502.v3
title: DynamicIntermediateAxisModel Worksheet

description: Worksheets of the Manuscript The Dynamic Intermediate Axis Model and the Solar Magnetic Field Flip Problem by Martin Ziegler<br><br>
DOI: 10.6084/m9.figshare.6359372.v2
title: B.A.Z.A. Propuesta de actividad para 1º ESO con Realidad Virtual Inmersiva

description: Ficha de estudiantes de la propuesta didáctica B.A.Z.A. Consta de tres sesiones y siete actividades en torno a contenidos sobre la Tierra y el Sistema Solar siguiendo una metodología de indagación escolar. Se propone como marco del problema una supuesta invasión alienígena a nuestro Sistema Solar. Una agencia de investigación requerirá su colaboración para investigar la posible presencia de los extraterrestres. Para ello los estudiantes recorrerán el Sistema Solar haciendo uso del modelo virtual y recopilaran información del mismo. En la tercera y última sesión compararán la información recopilada con un modelo totalmente a escala haciendo uso del programa Celestia.<br>
DOI: 10.6084/m9.figshare.23813799.v1
title: #<i>SafeHandsSafeHearts</i> Project - Toronto_Dataset

description: Dataset for #SafeHandsSafeHearts project
DOI: 10.6084/m9.figshare.25854001.v2
title: Banco_final_site.xlsx

description: Trata-se de uma pesquisa transversal, com amostragem probabilística aleatória simples estratificada proporcional, na qual foram aplicados instrumentos de caracterização da amostra, de avaliação da multimorbidade e da funcionalidade, além do Inventário de Ansiedade Geriátrica (GAI) e da Escala de Depressão Geriátrica (GDS) para o rastreio de sintomas depressivos e ansiosos.
DOI: 10.6084/m9.figshare.17091086.v1
title: Supplementary Material for: Dysregulated MDR1 by PRDM1/Blimp1 Is Involved in the Doxorubicin Resistance of Non-Germinal Center B-Cell-Like Diffuse Large B-Cell Lymphoma

description: <b><i>Introduction:</i></b> The chemoresistance mechanism of diffuse large B-cell lymphoma (DLBCL) is still poorly understood, and patient prognosis remains unsatisfactory. This study aimed to investigate drug resistance mechanisms in non-germinal center B-cell-like (non-GCB) DLBCL. <b><i>Methods:</i></b> Doxorubicin (DOX)-resistant OCI-Ly3 cells were generated through long-term incubation of cells in a medium with gradually increasing DOX concentrations. The expression levels of genes related to drug metabolism were determined using a functional gene grouping polymerase chain reaction (PCR) array. Drug-resistant proteins were identified using bioinformatics, and molecular association networks were subsequently generated. The association and mechanism of key genes were determined using a dual-luciferase reporter assay System and chromatin immunoprecipitation (ChIP). The expression of drug-resistant genes and target genes was then measured using Western blotting and immunohistochemistry. The correlation between gene expressions was analyzed using Spearman’s rank correlation coefficient. <b><i>Results:</i></b> Using the PCR array, <i>MDR1</i> was identified as the key gene that regulates DOX resistance in OCI-Ly3/DOX-A100, a non-GCB DLBCL cell line. The dual-luciferase reporter assay system demonstrated that <i>MDR1</i> transcription could be inhibited by PRDM1. ChIP results showed that PRDM1 had the ability to bind to the promoter region (−1,132 to −996) of <i>MDR1</i>. In OCI-Ly3/DOX cells, NF-κB activity and PRDM1 expression decreased with an increase in drug-resistant index, whereas <i>MDR1</i> expression increased with enhanced drug resistance. Immunohistochemical analysis revealed that relative <i>MDR1</i> expression was higher than that of PRDM1 in human DLBCL tissue samples. A negative correlation was observed between MDR1 and PRDM1. <b><i>Conclusion:</i></b> In non-GCB DLBCL cells, NF-κB downregulates PRDM1 and thereby promotes <i>MDR1</i> transcription by terminating PRDM1-induced transcriptional inhibition of <i>MDR1</i>. Such a mechanism may explain the reason for disease recurrence in non-GCB DLBCL after R-CHOP or combined CHOP with bortezomib treatment. Our findings may provide a potential therapeutic strategy for reducing drug resistance in patients with DLBCL.
DOI: 10.6084/m9.figshare.18025325.v1
title: data

description: Input data for reproduce results in paper "Multiplexed imaging mass cytometry reveals distinct tumor-immune microenvironments l inked to immunotherapy responses in melanoma"
DOI: 10.6084/m9.figshare.23275193.v1
title: GAF-QCNN

description: as read me.txt
DOI: 10.6084/m9.figshare.7931534.v1
title: gVCF_HG04173

description: 1000 Genomes gVCF mapped to hs37d5 for HG04173. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.21942/uva.17218724.v1
title: Spatial polygons for Sunda, Timor, and Caribbean regions.

description: <b>DESCRIPTION:</b><br><br> Spatial polygons for Sunda, Timor, and Caribbean regions.<br> These are used for drawing region-scale figures (Fig. S2)<br><br><b>CAUTION:</b><br><br> These are hand-drawn to roughly capture the tendencies around the focal regions.<br> <br><br>
DOI: 10.6084/m9.figshare.13573232.v1
title: Supplementary Material for: A Case Report of Pediatric Geniculate Neuralgia Treated with Sectioning of the Nervus Intermedius and Microvascular Decompression of Cranial Nerves IX and X

description: <b><i>Background:</i></b> Classic geniculate neuralgia (GN) is a rare condition characterized by lancinating pain centered in the ear and not involving the throat. To the best of our knowledge, no case of pediatric GN has been reported in the English literature. <b><i>Case Presentation:</i></b> We present the first reported case of successfully treated GN in a child via an endoscopic approach. The patient was a 9-year-old boy who presented with a 1-year history of lancinating right ear pain. Neuroleptics resulted in a short-lived improvement in symptoms, but with significant side effects. Extensive evaluation by multiple specialties did not reveal a cause for his pain. Imaging disclosed a tortuous loop of the right posterior inferior cerebellar artery abutting cranial nerves IX and X but no other abnormalities. The patient underwent an endoscopic microvascular decompression of cranial nerves IX and X, and sectioning of the nervus intermedius through a right retromastoid craniotomy. Postoperatively, the patient reported complete resolution of his symptoms that persisted at 3 months of follow-up. At the 5-year follow-up, the patient maintained pain relief and was developing normally. <b><i>Conclusion:</i></b> GN can affect the pediatric population. In carefully selected patients with consistent clinical and radiographic presentation, sectioning of the nervus intermedius and microvascular decompression of the lower cranial nerves can be an effective treatment.
DOI: 10.6084/m9.figshare.28683380.v1
title: LBA001_inaquosorum_stats.txt

description: Statistic file for B.inaquosorum LBA001