cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.13606423.v1
title: Autophagy activation, lipotoxicity and lysosomal membrane permeabilization synergize to promote pimozide- and loperamide-induced glioma cell death

description: Increasing evidence suggests that induction of lethal macroautophagy/autophagy carries potential significance for the treatment of glioblastoma (GBM). In continuation of previous work, we demonstrate that pimozide and loperamide trigger an ATG5- and ATG7 (autophagy related 5 and 7)-dependent type of cell death that is significantly reduced with cathepsin inhibitors and the lipid reactive oxygen species (ROS) scavenger α-tocopherol in MZ-54 GBM cells. Global proteomic analysis after treatment with both drugs also revealed an increase of proteins related to lipid and cholesterol metabolic processes. These changes were accompanied by a massive accumulation of cholesterol and other lipids in the lysosomal compartment, indicative of impaired lipid transport/degradation. In line with these observations, pimozide and loperamide treatment were associated with a pronounced increase of bioactive sphingolipids including ceramides, glucosylceramides and sphingoid bases measured by targeted lipidomic analysis. Furthermore, pimozide and loperamide inhibited the activity of SMPD1/ASM (sphingomyelin phosphodiesterase 1) and promoted induction of lysosomal membrane permeabilization (LMP), as well as release of CTSB (cathepsin B) into the cytosol in MZ-54 wild-type (WT) cells. Whereas LMP and cell death were significantly attenuated in <i>ATG5</i> and <i>ATG7</i> knockout (KO) cells, both events were enhanced by depletion of the lysophagy receptor VCP (valosin containing protein), supporting a pro-survival function of lysophagy under these conditions. Collectively, our data suggest that pimozide and loperamide-driven autophagy and lipotoxicity synergize to induce LMP and cell death. The results also support the notion that simultaneous overactivation of autophagy and induction of LMP represents a promising approach for the treatment of GBM. <b>Abbreviations</b>: ACD: autophagic cell death; AKT1: AKT serine/threonine kinase 1; ATG5: autophagy related 5; ATG7: autophagy related 7; ATG14: autophagy related 14; CERS1: ceramide synthase 1; CTSB: cathepsin B; CYBB/NOX2: cytochrome b-245 beta chain; ER: endoplasmatic reticulum; FBS: fetal bovine serum; GBM: glioblastoma; GO: gene ontology; HTR7/5-HT7: 5-hydroxytryptamine receptor 7; KD: knockdown; KO: knockout; LAMP1: lysosomal associated membrane protein 1; LAP: LC3-associated phagocytosis; LMP: lysosomal membrane permeabilization; MAP1LC3B: microtubule associated protein 1 light chain 3 beta; MTOR: mechanistic target of rapamycin kinase; RB1CC1: RB1 inducible coiled-coil 1; ROS: reactive oxygen species; RPS6: ribosomal protein S6; SMPD1/ASM: sphingomyelin phosphodiesterase 1; VCP/p97: valosin containing protein; WT: wild-type.
DOI: 10.6084/m9.figshare.17111897
title: Increasing Extreme Precipitation Exacerbates Spatial Patterns of Pluvial Flood Risks in China_Supplement Video

description: <b>Increasing Extreme Precipitation Exacerbates Spatial Patterns</b><b> of Pluvial</b> <b>Flood Risks in China</b>
DOI: 10.5281/zenodo.5749676
title: Martian Dust Storms and Gravity Waves: Disentangling Water Transport to the Upper Atmosphere

description: The data for JGR:Planets article figures.
DOI: 10.5281/zenodo.5573962
title: Martian Dust Storms and Gravity Waves: Disentangling Water Transport to the Upper Atmosphere

description: The data for JGR:Planets article figures.
DOI: 10.5281/zenodo.5749678
title: Poicephalus robustus SPAdes preassembly

description: .
DOI: 10.5281/zenodo.5749677
title: Poicephalus robustus SPAdes preassembly

description: .
DOI: 10.6084/m9.figshare.17105324
title: ICFstroke_Rasch_Mokken

description: 130 inpatients with stroke assessed via <i>International Classification of Functioning, Disability and Health</i> (ICF)
DOI: 10.6084/m9.figshare.17105324.v3
title: ICFstroke_Rasch_Mokken

description: 130 inpatients with stroke assessed via <i>International Classification of Functioning, Disability and Health</i> (ICF)
DOI: 10.6084/m9.figshare.17105324.v2
title: ICFstroke_Rasch_Mokken

description: 130 inpatients with stroke assessed via <i>International Classification of Functioning, Disability and Health</i> (ICF)
DOI: 10.15480/336.3773
title: Thrombus - Experiments

description: DSA-Dateien und Videos von Versuchsreihen zur Beurteilung der Eigenschaften synthetischer Thromben.
description: DSA files and videos of experimental series to assess the properties of synthetic thrombi.
DOI: 10.5281/zenodo.5749352
title: VESPA mercury_mag_boundaries sample

description: This dataset is based on the original MESSENGER mission magnetometer and coordinate data as made available at PDS PPI. It introduces a number of improvements upon the original [1 sec temporal resolution]: Magnetometer calibration signals have been removed. Coordinates and magnetic field measurements have been merged together. Additional fields, such as model dipole magnetic field and planetary position in a heliocentric coordinate system have been added. The dataset has been split up into files by orbit numbers, with each file centered on the periapsis. Data for a number of partially recorded orbits has been removed.
DOI: 10.5281/zenodo.5749351
title: VESPA mercury_mag_boundaries sample

description: This dataset is based on the original MESSENGER mission magnetometer and coordinate data as made available at PDS PPI. It introduces a number of improvements upon the original [1 sec temporal resolution]: Magnetometer calibration signals have been removed. Coordinates and magnetic field measurements have been merged together. Additional fields, such as model dipole magnetic field and planetary position in a heliocentric coordinate system have been added. The dataset has been split up into files by orbit numbers, with each file centered on the periapsis. Data for a number of partially recorded orbits has been removed.
DOI: 10.14459/2021mp1633461
title: So2Sat GUL - So2Sat Global Urban LCZs

description: So2Sat GUL consists of the local climate zones classification maps of 1692 cities whose population are larger than 300,000 according to the United Nations' World Urbanization Prospects: The 2014 Revision.
DOI: 10.5281/zenodo.5732457
title: Input files, plotting scripts, and figures for "Smoldering combustion in cellulose and hemicellulose mixtures: Examining the roles of density, fuel composition, oxygen concentration, and moisture content"

description: This bundle of files contains all the Gpyro input files, data, plotting scripts, and figures for "Smoldering combustion in cellulose and hemicellulose mixtures: Examining the roles of density, fuel composition, oxygen concentration, and moisture content". The README.txt file contains additional details about the contents.
description: This research was funded by the Strategic Environmental Research and Development Program (SERDP) award RC-2651 under contract number W912HQ-16-C-0045. We also thank David Blunck, Benjamin Smucker, and Daniel Cowan from Oregon State University for providing their experimental temperature measurements data for validation. The views, opinions, and/or findings contained in this report are those of the authors and should not be construed as an official Department of Defense position of decision unless so designated by other official documentation.
DOI: 10.5281/zenodo.3358192
title: Input files, plotting scripts, and figures for "Smoldering combustion in cellulose and hemicellulose mixtures: Examining the roles of density, fuel composition, oxygen concentration, and moisture content"

description: This bundle of files contains all the Gpyro input files, data, plotting scripts, and figures for "Smoldering combustion in cellulose and hemicellulose mixtures: Examining the roles of density, fuel composition, oxygen concentration, and moisture content". The README.txt file contains additional details about the contents.
description: This research was funded by the Strategic Environmental Research and Development Program (SERDP) award RC-2651 under contract number W912HQ-16-C-0045. We also thank David Blunck, Benjamin Smucker, and Daniel Cowan from Oregon State University for providing their experimental temperature measurements data for validation. The views, opinions, and/or findings contained in this report are those of the authors and should not be construed as an official Department of Defense position of decision unless so designated by other official documentation.
DOI: 10.5281/zenodo.5024741
title: A comparison among three ways to assemble wall-to-wall land-cover maps from distribution models of vegetation types

description: Dataset accompanying manuscript <em>"A comparison among three ways to assemble wall-to-wall land-cover maps from distribution models of vegetation types". </em>Datasets contain a wall-to-wall map of vegetation types covering the study area of terrestrial Norway, produced using three methods for assembling individual predictions from Distribution models (<em>probability-based method</em>, <em>performance-based method</em> and <em>prevalence-based method</em>).
DOI: 10.5281/zenodo.5024740
title: A comparison among three ways to assemble wall-to-wall land-cover maps from distribution models of vegetation types

description: Dataset accompanying manuscript <em>"A comparison among three ways to assemble wall-to-wall land-cover maps from distribution models of vegetation types". </em>Datasets contain a wall-to-wall map of vegetation types covering the study area of terrestrial Norway, produced using three methods for assembling individual predictions from Distribution models (<em>probability-based method</em>, <em>performance-based method</em> and <em>prevalence-based method</em>).
DOI: 10.5281/zenodo.5749704
title: Gallinago paraguaiae SPAdes preassembly

description: .
DOI: 10.5281/zenodo.5749703
title: Gallinago paraguaiae SPAdes preassembly

description: .
DOI: 10.5281/zenodo.5749223
title: PENELLOPE - X-Shooter spectra of targets in the Lupus and Chamaeleon regions observed in 2021

description: Spectra of the targets in the Lupus, Chamaeleon I and eta-Cha regions observed with the VLT/X-Shooter spectrograph in May-August 2021. These spectra are part of the PENELLOPE Large Program and are obtained close in time to the HST/ULLYSES spectra of the same targets. Here one can find the 1D absolute flux-calibrated and telluric corrected spectra. Each object is observed simultaneously in three arms, UVB, VIS, and NIR, and the spectrum of each arm is saved in one file. The units of the spectra are: Flux [erg/s/cm2/nm]; Wavelength [nm]. In some cases, multiple observations for one target have been taken. Data are public, we ask to ask to the authors of this release, who contributed to the observation preparation and data reduction, whether they want to be included in any publication using these data. The data reduction procedure is presented in Manara et al. (2021). Please quote this paper in any related publication. Please contact Carlo Manara for estimates of the stellar and accretion properties of these targets based on this data. For questions or comments please contact Carlo Manara, cmanara@eso.org
DOI: 10.5281/zenodo.5749230
title: PENELLOPE - UVES spectra of targets in the Lupus and Chamaeleon regions observed in 2021

description: Spectra of the targets in the Chamaeleon I and Lupus regions observed with the VLT/UVES spectrograph in June-July 2021. These spectra are part of the PENELLOPE Large Program and are obtained close in time to the HST/ULLYSES spectra of the same targets. Here one can find the 1D flux-calibrated and telluric corrected spectra. Each object is observed simultaneously in three arms, blue, redu, redl, and the spectrum of each arm is saved in one file. The units of the spectra are: Flux [10**-16 erg/s/cm2/AA]; Wavelength [AA]. Each object is typically observed 3 times, the spectra are thus labelled as ep1, ep2, ep3. Data are public, we ask to ask to the authors of this release, who contributed to the observation preparation and data reduction, whether they want to be included in any publication using these data. The data reduction procedure is presented in Manara et al. (2021). Please quote this paper in any related publication. Please contact Carlo Manara for estimates of the stellar and accretion properties of these targets based on the corresponding X-Shooter data, and Antonio Frasca for stellar properties based on this data. For questions or comments please contact Carlo Manara, cmanara@eso.org
DOI: 10.5281/zenodo.5749222
title: PENELLOPE - X-Shooter spectra of targets in the Lupus and Chamaeleon regions observed in 2021

description: Spectra of the targets in the Lupus, Chamaeleon I and eta-Cha regions observed with the VLT/X-Shooter spectrograph in May-August 2021. These spectra are part of the PENELLOPE Large Program and are obtained close in time to the HST/ULLYSES spectra of the same targets. Here one can find the 1D absolute flux-calibrated and telluric corrected spectra. Each object is observed simultaneously in three arms, UVB, VIS, and NIR, and the spectrum of each arm is saved in one file. The units of the spectra are: Flux [erg/s/cm2/nm]; Wavelength [nm]. In some cases, multiple observations for one target have been taken. Data are public, we ask to ask to the authors of this release, who contributed to the observation preparation and data reduction, whether they want to be included in any publication using these data. The data reduction procedure is presented in Manara et al. (2021). Please quote this paper in any related publication. Please contact Carlo Manara for estimates of the stellar and accretion properties of these targets based on this data. For questions or comments please contact Carlo Manara, cmanara@eso.org
DOI: 10.5281/zenodo.5749229
title: PENELLOPE - UVES spectra of targets in the Lupus and Chamaeleon regions observed in 2021

description: Spectra of the targets in the Chamaeleon I and Lupus regions observed with the VLT/UVES spectrograph in June-July 2021. These spectra are part of the PENELLOPE Large Program and are obtained close in time to the HST/ULLYSES spectra of the same targets. Here one can find the 1D flux-calibrated and telluric corrected spectra. Each object is observed simultaneously in three arms, blue, redu, redl, and the spectrum of each arm is saved in one file. The units of the spectra are: Flux [10**-16 erg/s/cm2/AA]; Wavelength [AA]. Each object is typically observed 3 times, the spectra are thus labelled as ep1, ep2, ep3. Data are public, we ask to ask to the authors of this release, who contributed to the observation preparation and data reduction, whether they want to be included in any publication using these data. The data reduction procedure is presented in Manara et al. (2021). Please quote this paper in any related publication. Please contact Carlo Manara for estimates of the stellar and accretion properties of these targets based on the corresponding X-Shooter data, and Antonio Frasca for stellar properties based on this data. For questions or comments please contact Carlo Manara, cmanara@eso.org
DOI: 10.6084/m9.figshare.16870850
title: MicroRNA hsa-miR-150-5p inhibits nasopharyngeal carcinogenesis by suppressing PYCR1 (pyrroline-5-carboxylate reductase 1)

description: Nasopharyngeal cancer is a rare cancer type, but with a low five-year survival rate. Dysregulation of pyrroline-5-carboxylate reductase 1 (PYCR1) and microRNA hsa-miR-150-5p is involved in the development of various cancers. However, the molecular mechanism of the hsa-miR-150-5p-PYCR1 axis in nasopharyngeal cancer remains unclear. To identify the mechanism of the hsa-miR-150-5p-PYCR1 axis, the expression of hsa-miR-150-5p and PYCR1 in nasopharyngeal cancer tissues and cells was first measured by reverse transcription quantitative polymerase chain reaction. The luciferase and RNA pull-down assays were used to confirm the interaction between hsa-miR-150-5p and PYCR1. The overexpression of hsa-miR-150-5p and PYCR1 was detected by cell viability, proliferation, western blotting, migration, and invasion in nasopharyngeal cancer cells. The expression levels of hsa-miR-150-5p was reduced in the nasopharyngeal cancer tissues and cells and were negatively correlated with the PYCR1 levels. The upregulation of hsa-miR-150-5p significantly repressed cell growth and promoted apoptosis. However, the upregulation of <i>PYCR1</i> expression significantly promoted nasopharyngeal carcinogenesis, which could abolish the inhibitory effect of hsa-miR-150-5p. In conclusion, we clarified that hsa-miR-150-5p attenuated nasopharyngeal carcinogenesis by reducing the <i>PYCR1</i> expression levels. This provides a new perspective of nasopharyngeal cancer involving both hsa-miR-150-5p and PYCR1 for the treatment of nasopharyngeal cancer.
DOI: 10.6084/m9.figshare.16870850.v1
title: MicroRNA hsa-miR-150-5p inhibits nasopharyngeal carcinogenesis by suppressing PYCR1 (pyrroline-5-carboxylate reductase 1)

description: Nasopharyngeal cancer is a rare cancer type, but with a low five-year survival rate. Dysregulation of pyrroline-5-carboxylate reductase 1 (PYCR1) and microRNA hsa-miR-150-5p is involved in the development of various cancers. However, the molecular mechanism of the hsa-miR-150-5p-PYCR1 axis in nasopharyngeal cancer remains unclear. To identify the mechanism of the hsa-miR-150-5p-PYCR1 axis, the expression of hsa-miR-150-5p and PYCR1 in nasopharyngeal cancer tissues and cells was first measured by reverse transcription quantitative polymerase chain reaction. The luciferase and RNA pull-down assays were used to confirm the interaction between hsa-miR-150-5p and PYCR1. The overexpression of hsa-miR-150-5p and PYCR1 was detected by cell viability, proliferation, western blotting, migration, and invasion in nasopharyngeal cancer cells. The expression levels of hsa-miR-150-5p was reduced in the nasopharyngeal cancer tissues and cells and were negatively correlated with the PYCR1 levels. The upregulation of hsa-miR-150-5p significantly repressed cell growth and promoted apoptosis. However, the upregulation of <i>PYCR1</i> expression significantly promoted nasopharyngeal carcinogenesis, which could abolish the inhibitory effect of hsa-miR-150-5p. In conclusion, we clarified that hsa-miR-150-5p attenuated nasopharyngeal carcinogenesis by reducing the <i>PYCR1</i> expression levels. This provides a new perspective of nasopharyngeal cancer involving both hsa-miR-150-5p and PYCR1 for the treatment of nasopharyngeal cancer.
DOI: 10.6084/m9.figshare.16818839.v2
title: Role of ferroptosis-related genes in Stanford type a aortic dissection and identification of key genes: new insights from bioinformatic analysis

description: Stanford type A aortic dissection (TAAD) is one of the most dangerous vascular diseases worldwide, and the mechanisms of its development remain unclear. Further molecular pathology studies may contribute to a comprehensive understanding of TAAD and provide new insights into diagnostic markers and potential therapeutic targets. Recent studies have identified that ferroptosis, a form of cell death, may play a previously unrecognized role in influencing the development of TAAD. In this study, we explored the pathological role of ferroptosis in TAAD by performing bioinformatics analyses. Gene set enrichment analysis (GSEA) showed that the ferroptosis-related gene (FRG) set was significantly different between normal and TAAD aortic samples at an overall level (<i>p</i>
DOI: 10.6084/m9.figshare.16818839
title: Role of ferroptosis-related genes in Stanford type a aortic dissection and identification of key genes: new insights from bioinformatic analysis

description: Stanford type A aortic dissection (TAAD) is one of the most dangerous vascular diseases worldwide, and the mechanisms of its development remain unclear. Further molecular pathology studies may contribute to a comprehensive understanding of TAAD and provide new insights into diagnostic markers and potential therapeutic targets. Recent studies have identified that ferroptosis, a form of cell death, may play a previously unrecognized role in influencing the development of TAAD. In this study, we explored the pathological role of ferroptosis in TAAD by performing bioinformatics analyses. Gene set enrichment analysis (GSEA) showed that the ferroptosis-related gene (FRG) set was significantly different between normal and TAAD aortic samples at an overall level (<i>p</i>
DOI: 10.6084/m9.figshare.16818839.v1
title: Role of Ferroptosis-Related Genes in Stanford Type A Aortic Dissection and Identification of Key Genes: New Insights from Bioinformatic Analysis

description: Stanford type A aortic dissection (TAAD) is one of the most dangerous vascular diseases worldwide, and the mechanisms of its development remain unclear. Further molecular pathology studies may contribute to a comprehensive understanding of TAAD and provide new insights into diagnostic markers and potential therapeutic targets. Recent studies have identified that ferroptosis, a form of cell death, may play a previously unrecognized role in influencing the development of TAAD. In this study, we explored the pathological role of ferroptosis in TAAD by performing bioinformatics analyses. Gene set enrichment analysis (GSEA) showed that the ferroptosis-related gene (FRG) set was significantly different between normal and TAAD aortic samples at an overall level (<i>p</i> &lt; 0.001). Further Gene Ontology (GO) enrichment analysis found that FRGs may influence the response to oxygen levels, transition metal ion homeostasis, and the response to hypoxia by regulating oxidoreductase activity and post-transcriptional ubiquitination modifications, which may regulate cellular ferroptosis and contribute to the structural abnormalities that render patients susceptible to TAAD. Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis revealed the HIF-1 signaling pathway may be a key pathway regulating cellular ferroptosis in TAAD development. We further identified six key genes (CA9, HMOX1, IL6, CDKN1A, HIF1A, MYC) from differentially expressed FRGs in TAAD by constructing a protein-protein interaction (PPI) network, all key genes were upregulated in TAAD. Four of the key genes (CA9, IL6, CDKN1A, and HIF1A) were demonstrated to be correlated with cigarette smoke extract-induced ferroptosis in aortic vascular smooth muscle cells. These results suggest that ferroptosis is one of the essential pathological processes in the development of TAAD, and some FRGs affect TAAD development by mediating cellular ferroptosis, which provides deepening insights into the molecular mechanisms and potential therapeutic targets of TAAD.
DOI: 10.26300/gprt-kw18
title: Association between receipt of results from an Amyloid Positron Emission Tormography (PET) to diagnose Alzheimer disease and 18-month changes in emotional wellbeing among care-partners of beneficiaries with moderate cognitive impairment or Alzheimer’s dise
DOI: 10.5281/zenodo.5749696
title: PEMA databases

description: In this repo, the CREST and the RDPTClassifier oriented databases unsed in PEMA will be versioned.
DOI: 10.34740/kaggle/dsv/2878583
title: COVID Vaccination in World (updated daily)
DOI: 10.6084/m9.figshare.17112512
title: Memristive properties of human stem cells differentiated to neurons

description: A list of all done measurements and whether pinched hysteresis loops were obtained or not
DOI: 10.6084/m9.figshare.17112512.v1
title: Memristive properties of human stem cells differentiated to neurons

description: A list of all done measurements and whether pinched hysteresis loops were obtained or not
DOI: 10.5281/zenodo.5749738
title: ERAI corresponding to KMA data

description: ERAI corresponding to KMA data
DOI: 10.5281/zenodo.5749737
title: ERAI corresponding to KMA data

description: ERAI corresponding to KMA data
DOI: 10.6084/m9.figshare.17112443.v1
title: Protocol A.docx

description: Improving motor skills data
DOI: 10.6084/m9.figshare.17112515
title: run.xlsx

description: Improving,motor,skills
DOI: 10.6084/m9.figshare.17112443
title: Protocol A.docx

description: Improving motor skills data