cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.25402/fsg.22588966
title: Single-day protein LC–MS bioanalysis: can next-generation trypsins cut it?: supplementary table 1

description: Aims: The drive toward more sensitive LC–MS assays has resulted in long, complex methods. We
assessed next-generation trypsins to identify a suitable candidate to integrate into protein LC–MS
method development strategies, to simplify methods and increase throughput. Materials & methods: The
performance of commercially available next-generation trypsins was assessed based on the digestion of
protein standards in buffer and complex matrix by LC–high-resolution MS. Results: The performance of
all next-generation trypsins assessed exceeded that of an overnight tryptic digest in a fraction of the
time. Performing reduction and alkylation prior to digestion with heat-stable trypsins may be beneficial
and should be investigated. Conclusion: Promega Rapid-Digestion
DOI: 10.25549/examiner-c44-15425
title: Damon Runyon, 1951

description: 3 images. Damon Runyon, 9 August 1951. Charles Morrison; Ethel Barrymore; Joan Crawford; Mrs. Charles Morrison.
DOI: 10.25402/bio.22588978
title: Determination of asundexian and its metabolite M-10 in human plasma by LC–MS/MS: supplementary materials

description: Background: The authors present a validated method for the simultaneous quantification of asundexian
(BAY 2433334) and its pharmacologically inactive major human metabolite M-10 from human plasma and
its application in clinical study sample analysis. Materials & methods: Sample preparation was performed
by protein precipitation followed by reverse phase HPLC and positive/negative ESI-MS/MS. Results: Assay
working ranges were 0.5–500 ng/ml for asundexian and 5.0–5000 ng/ml for M-10. Validation results
met the requirements of pertinent guidelines. In clinical study sample analysis, accuracy and precision
acceptance criteria for analyzed quality control samples were met and incurred sample reanalysis was
fulfilled. Conclusion: The method proved to be selective, specific, sufficiently sensitive, reproducible and
robust for the analysis of samples obtained from clinical trials.
DOI: 10.25402/bio.22634368
title: Development and validation of LC–MS/MS method for quantitation of sodium oligomannate in human plasma, urine and feces: supplementary materials

description: Background: Sodium oligomannate was approved for marketing by the National Medical Products
Administration of China in 2019 for improving cognitive functions in mild-to-moderate Alzheimer’s
disease patients. Method: LC–MS/MS methods were established and validated for the quantitation of
sodium oligomannate in human plasma, urine and feces to support clinical development studies. Samples
were prepared using liquid–liquid extraction and analyzed by ion-pair reversed-phase LC–MS/MS with
calibration standard curve ranges of 25.0–5000 ng/ml, 0.500–100 μg/ml and 100–10,000 μg/g in plasma,
urine and feces, respectively. Results & conclusion: All validation parametersmet the respective acceptance
criteria established by US FDA and International Council for Harmonisation of Technical Requirements for
Human Use guidelines. The validated methods were applied to a pharmacokinetics and excretion study in
healthy Chinese subjects.
DOI: 10.25549/examiner-c44-15869
title: Examiner War Wounded Fund (San Diego and Oceanside), 1951

description: 15 images. Examiner War Wounded Fund (San Diego and Oceanside), 2 August 1951. Lieutenant Clarence D. Lynn; Mrs. Viola Lynn; Corporal C.E. Rekdahl; F.P. Murphy; Private First Class R.W. Medsker; Sergeant C.A. Tully; Corporal T.J. Stevens; Corporal J.D. Lowermilk; Corporal Harry McDonalt; Private First Class Bill Vaugn; Rex Flint; Private First Class W.H. Brawner; Corporal Tommy R. Young; Private First Class Henry Brady; Archie Watts; Joseph Hooper; Gerard Golden.; Caption slip reads: "Photographer; Miller. Date; 08-02. Reporter: Driscoll. Assignment; Examiner war wounded fund. Captions: War wounded, Oceanside and San Diego, Aug. 2. To be used Sunday or Monday, Aug. 5 or 6. 4-20: San Diego Naval Hospital. Navy Lieutenant Clarence D. Lynn and wife, Viola. Home, San Diego. Wounded aboard USS Thompson off Songjin. Shell from enemy shore battery hit ship. 21-22: Naval Hospital, Oceanside (Camp Pendleton). Corporal C.E. Rekdahl, Los Angeles. Hospital Corpsman Third Class F.P. Murphy mustering Korean wounded for $10 bill distribution. (He's not a patient; stationed at hospital). Private First Class R.W. Medsker, Compton; Sergeant C.A. Tully, Santa Monica; Corporal T.J. Stevens, Oceanside. 7-8: Oceanside. Corporal J.D. Lowdermilk of Long Beach. Wounded in Iron triangle fighting. Legs burned with gasoline. Hospital Corpsman J.H. Palmer administering treatment which Lowdermilk says can wait until he sees what's in the war wounded envelope".; Caption slip continues: "18, 20: San Diego Naval Hospital. Corporal Harry McDonald, Pasadena, Private First Class Bill Vaughn, Havana, Illinois, one of Southern California's temporary guests getting a Southern California welcome. 19: San Diego. Corporal Stan Rysiejko, Bridgeport, Connecticut. Wounded near one of those reservoirs which are bad places for Marines'. 9-10: Private First Class Rex Flint, Riverside. Wounded at Wonchon. 11-12: Private First Class W.H. Brawner, Compton; Corporal Tommy R. Young, South Gate; Private First Class Henry Brady, Long Beach. (This is the group in which the man in the middle has arm in a metal frame) At Oceanside. 23-24: Oceanside. Group. Standing: Master Sergeant Archie Watts, Santa Ana; Corporal Joseph Hooper, Houston, Texas; Master Sergeant Gerard Golden, Scranton, Pennsylvania; Master Sergeant William J. Knight, Norwalk; Master Sergeant N.E. Zirkle, Belford, Ohio; Hospital Corpsman Third Class A. Singleton, Chicago; Corporal R. Reyes, Tucson; Machinist's mate Third Class J.P. Ellison, Sioux City, Iowa. Sitting: Sergeant Frank D. Povero, Montour Falls, New York; Corporal R.S. Matheny, Riverside; Private First Class Frank J. Marino, Oceanside. All Marines, except Ellison and Singleton -- they're Navy".
DOI: 10.15468/dl.uv6c36
title: Occurrence Download

description: A dataset containing 4108 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Solanum granulosoleprosum Dunal"
 ]
}

 The dataset includes 4108 records from 152 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0018194-240506114902167/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.25402/bio.22634368.v1
title: Development and validation of LC–MS/MS method for quantitation of sodium oligomannate in human plasma, urine and feces: supplementary materials

description: Background: Sodium oligomannate was approved for marketing by the National Medical Products
Administration of China in 2019 for improving cognitive functions in mild-to-moderate Alzheimer’s
disease patients. Method: LC–MS/MS methods were established and validated for the quantitation of
sodium oligomannate in human plasma, urine and feces to support clinical development studies. Samples
were prepared using liquid–liquid extraction and analyzed by ion-pair reversed-phase LC–MS/MS with
calibration standard curve ranges of 25.0–5000 ng/ml, 0.500–100 μg/ml and 100–10,000 μg/g in plasma,
urine and feces, respectively. Results & conclusion: All validation parametersmet the respective acceptance
criteria established by US FDA and International Council for Harmonisation of Technical Requirements for
Human Use guidelines. The validated methods were applied to a pharmacokinetics and excretion study in
healthy Chinese subjects.
DOI: 10.25402/bio.22634386
title: Comparison of pharmacokinetic study profiles of insulin in rat plasma through conventional sampling and microsampling by micro-LC–MS/MS: supplementary materials

description: Aim: With microsamples of blood, full pharmacokinetic profiles from individual animals can be obtained as
an alternative to the sparse-sampling approach, where conventional volume samples from several animals
are required. However, microsamples require assays that are more sensitive. Methods: The sensitivity of
the LC–MS assay was increased 47-fold using microflow LC–MS. Results & conclusion: By analyzing both
microsamples and conventional samples from the same animals, it is demonstrated that sparse-sampling
profiles can be nonrepresentative of the full profiles. This bias can affect the tested treatment by increasing
or reducing its apparent effect. Microsampling enables unbiased results compared with sparse-sampling.
An increase in assay sensitivity to balance the low sample volumes was achievable by microflow LC–MS.
DOI: 10.25549/examiner-c44-20850
title: Melody Ball of Las Angelinas...Society, 1951

description: 14 images. Melody Ball of Las Angelinas...Society, 02 August 1951. Mrs. Kenneth Lake; Mrs. Don Bleitz; Mrs. Robert McMillan; Mrs. Milton Lewis; Mrs. Henry K. Orman; Mrs. John Ferraro; Mrs. Voltaire Perkins; Mrs. John A. Matthay; Mrs. Harold McAlister; Mrs. Robert Clark; Mrs. Phillip S. Kamm; Mrs. Rulon R. Free. (Sleeve reads: S9302).; Caption slip reads: "Photographer: McCarty. Date: 08-01. 31/32: Mrs. Kenneth Lake, seated; [Mrs.] Don Bleitz; [Mrs.] Robert McMillan; [Mrs.] Milton Lewis. 33/34: Mrs. Kenneth Lake; [Mrs.] Don Bleitz; [Mrs.] Milton Lewis; [Mrs.] Robert McMillan. 27/28/29/30: Mrs. Henry K. Orman; [Mrs.] John Ferraro; [Mrs.] Voltaire Perkins; [Mrs.] John A. Matthay; [Mrs.] Harold McAlister. 35/36: Mrs. Robert Clark; [Mrs.] Phillip S. Kamm; [Mrs.] Rulon R. Free. 38: [Mrs.] Rulon Free; [Mrs.] Robert Clark; [Mrs.] Phillip S. Kamm. 37, 39: Mrs. Vernon Bettin; Miss Mystery Melody".
DOI: 10.25402/bio.22656574
title: LC–MS/MS method for the quantitation of OCT1 biomarker isobutyrylcarnitine in human plasma with clinical sample analysis: supplementary data

description: Aim: Isobutyrylcarnitine (IBC) is a possible biomarker for hepatic OCT1, as IBC plasma concentrations are
reduced when OCT1 is inhibited. An accessible, characterized assay is needed to quantitate IBC in human
plasma. Materials & methods: A triple quadrupole MS surrogate matrix assay for the quantitation of
IBC was characterized to support a first-in-human study. Results: An assay for IBC quantitation was fully
characterized for accuracy, precision, selectivity and parallelism. IBC was measured in a clinical study and
the data were correlated to the in vitro model prediction. Conclusion: A triple quadrupole-based assay
for IBC should broaden the monitoring of IBC for OCT1 inhibition in early clinical trials, generating the
data needed to establish IBC as a valid biomarker.
DOI: 10.25549/examiner-c44-14941
title: Franklin Canyon reservoir, 1951

description: 4 images. Franklin Canyon reservoir, 3 August 1951. General view of abandoned reservoir where dog was rescued - and still remains a hazard to children etc.
DOI: 10.25402/bio.22674388
title: Simultaneous determination of four antibiotics in human plasma by high-performance LC–MS/MS: application to therapeutic drug monitoring: supplementary materials

description: Background: Aimed to simultaneously measure linezolid, voriconazole, cefoperazone and fluconazole
in human plasma suitable for therapeutic drug monitoring applications, a robust, rapid and easy-touse
HPLC–MS/MS approach was developed and validated. Materials & methods: Protein precipitation
was used to prepare analytes from 100 μl plasma. HPLC was employed for analyte separation, and
quantification was conducted via multiple reaction monitoring in positive ion mode. The methodology
was fully validated. Results & conclusion: All four antibiotics were found to be stable under the tested
conditions, and accuracy values ranged from 90.96 to 113.25% and CV values were &lt;14.0%. This HPLC–
MS/MS method can be used for routine clinical therapeutic drug monitoring of linezolid, voriconazole,
cefoperazone and fluconazole simultaneously.
DOI: 10.25402/bio.22674388.v1
title: Simultaneous determination of four antibiotics in human plasma by high-performance LC–MS/MS: application to therapeutic drug monitoring: supplementary materials

description: Background: Aimed to simultaneously measure linezolid, voriconazole, cefoperazone and fluconazole
in human plasma suitable for therapeutic drug monitoring applications, a robust, rapid and easy-touse
HPLC–MS/MS approach was developed and validated. Materials & methods: Protein precipitation
was used to prepare analytes from 100 μl plasma. HPLC was employed for analyte separation, and
quantification was conducted via multiple reaction monitoring in positive ion mode. The methodology
was fully validated. Results & conclusion: All four antibiotics were found to be stable under the tested
conditions, and accuracy values ranged from 90.96 to 113.25% and CV values were &lt;14.0%. This HPLC–
MS/MS method can be used for routine clinical therapeutic drug monitoring of linezolid, voriconazole,
cefoperazone and fluconazole simultaneously.
DOI: 10.25549/examiner-c44-20756
title: New Postmaster of Pasadena, 1951

description: 2 images. New Postmaster of Pasadena, 27 September 1951. Raymond R. Holmquist -- 37 years.; Caption slip reads: "Daily. Photographer: Richardson. Date: 1951-09-28. Reporter: Swaim. Assignment: Postmaster. K5, 6: Raymond R. Holmquist, 37, reading telegram notifying him of confirmation by Senate as new Postmaster of Pasadena".
DOI: 10.25402/bio.22726262
title: Development of Fe3O4/reduced graphene oxide nanocomposite-based dispersive solid-phase extraction for the quantification of five steroid hormones: supplementary materials

description: Aim: An accurate and sensitive analytical method was proposed to detect some steroid hormones
in biological samples. Materials & methods: An Fe3O4/reduced graphene oxide nanocomposite-based
dispersive solid-phase extraction was developed for the effective and simple preconcentration of steroid
hormones from human serum samples. Results & conclusion: The nanocomposite was firstly used as
adsorbent to simultaneously extract the selected hormones. Limit of detection values for the selected
hormones were calculated between 5.5 and 39.2 ng/kg (mass based). An artificial serum sample was used
to test the applicability and accuracy of the developedmethod; percentage recovery results obtained from
two different spiked concentrations were found to be in the range of 80.5–99.9%.
DOI: 10.25549/examiner-c44-15288
title: USO party, Hollywood, 1951

description: 12 images. United Service Organizations party, Hollywood, 12 August 1951. Mary Airhart (USO hostess); Frank B. Eisenhardt (DMSA of New Jersey); Juanita Flamer (Long Beach dancer); George Pacholski; Bill Schwartz; Richard Gonzales; Paul Stimson.
DOI: 10.25402/bio.22726280
title: Stability of nonsteroidal anti-inflammatory drugs in urine and solution: effects of degradation on analytical assessment: supplementary materials

description: Aims: Knowledge of optimal storage conditions of drugs is crucial for properly interpreting analytical
assessments. Materials & methods: The current study aimed to investigate the stability of some
nonsteroidal anti-inflammatory drugs using a validated method by gas chromatography (GC)–MS. For this
propose, long-term, short-term and solution stability were investigated. Results: The analytes remained
stable in the sample, similar to the working solution. The most affected substance over time in both
matrix and working solution was phenylbutazone. The freeze–thaw cycle affected flunixin and carprofen,
but diclofenac and vedaprofen changed only in the third cycle. In short-term stability, high-temperature
conditions changed carprofen. Conclusion: The present study is a comprehensive assay for nonsteroidal
anti-inflammatory drug stability and can be used as a reference for results assessment.
DOI: 10.25549/examiner-c44-19567
title: Plane crash and fire...West El Monte, 1951

description: 14 images. Plane crash and fire...West El Monte, 5 September 1951. James B. Howell -- 67 years (father of dead boy); Eva Howell -- 39 years (his wife); Robert White, Junior -- 13 years (playmate of dead boy); Cocker Spaniel "Pal"; Raymond James Howell -- 16 years; Ersel Syfert -- 16 years (girl friend of dead boy).; Caption slip reads: "Photographer: McCarty. Date: 1951-09-05. Reporter: Rose. Assignment: West El Monte Plane crash and fire. 41, 42: Lt. to Rt.: James B. Howell, 67, father of dead boy, and his wife, Eva, 39, seated in car before leaving scene in dazed condition. 37, 38: Wreckage of plane into rear of house at 2317 North Loma Ave., West El Monte. 51, 52: In tears, Ersel Syfert, 16, dead boy's girl friend, consoles his cocker spaniel Pal. 53: Charred body (wrapped in rubber sheet) of Raymond James Howell, 16. 42: County firemen looking at body of unidentified pilot. 55: Unidentified pilot's body. 49 & 50: Robert White Jr., 13, playmate of dead boy, consoles the boy's cocker spaniel, Pal. 45 & 48: Copy of picture of dead boy, Raymond James Howell, 16".
DOI: 10.25549/examiner-c44-15334
title: Highland games, 1951

description: 8 images. Highland games, 11 August 1951. Arleen Boruck; Donella Mary Turner; Linda Brownie; Bill Jones; Gordon Boyce; John H. Floyd Jr.; Robert C. McKinney.
DOI: 10.25549/examiner-c44-19813
title: El Segundo girls physical education, 1948

description: 12 images. El Segundo girls physical education, 9 November 1948. Joy Miller; Joan Bell; Joanne Engle; Marilyn Baker; Darlene Lareau; Ruth Douglas; Shirley Bruer; Rosalie Prosser; Betty Allison.; Caption slip reads: "Photographer: Jensen. Assignment: El Segundo girls physical education. 19-20, 50-51-52: Speed ball. Joy Miller, Joan Bell; Joanne Engle (kicking); Marilyn Baker; Darlene Lareau. Field Hockey: Ruth Douglas (Goalie); Shirley Bruce; Rosalie Prosser; Betty Allison. In back, L to R: Pat Tracy; Joanne Keith; Nancy Tuck".
DOI: 10.25402/bio.22836110
title: Quantitative chromatographic method development for residual lidocaine in topical systems and biological samples: supplementary materials

description: Background: The aim of this work was to develop and validate sensitive and efficient analytical methods
for estimating systemic drug exposure and residual drug following the application of topical delivery
systems. Materials & methods: Lidocaine was extracted using a liquid–liquid extraction technique from
commercial topical products and analyzed using ultra high-performance liquid chromatography. A
separate LC–MS/MS method was developed for analyzing human serum samples. Results & conclusion:
The developed methods were successfully applied for estimating lidocaine content in two commercial
products demonstrating 97.4–104.0% for product A and 105.0–110.7% for product B. The LC–MS/MS
method displayed successful analysis of lidocaine from human serum samples. The developed methods
are recommended for quantifying systemic exposure and residual drug analysis of topical systems.
DOI: 10.25402/bio.22836110.v1
title: Quantitative chromatographic method development for residual lidocaine in topical systems and biological samples: supplementary materials

description: Background: The aim of this work was to develop and validate sensitive and efficient analytical methods
for estimating systemic drug exposure and residual drug following the application of topical delivery
systems. Materials & methods: Lidocaine was extracted using a liquid–liquid extraction technique from
commercial topical products and analyzed using ultra high-performance liquid chromatography. A
separate LC–MS/MS method was developed for analyzing human serum samples. Results & conclusion:
The developed methods were successfully applied for estimating lidocaine content in two commercial
products demonstrating 97.4–104.0% for product A and 105.0–110.7% for product B. The LC–MS/MS
method displayed successful analysis of lidocaine from human serum samples. The developed methods
are recommended for quantifying systemic exposure and residual drug analysis of topical systems.
DOI: 10.25549/examiner-c44-19056
title: University of California Los Angeles tunnels, 1951

description: 11 images. University of California Los Angeles tunnels, 24 August 1951. Bert Hoskins (Assistant Chief Engineer); Don Crisp.; Caption slip reads: "Photographer: Sandusky. Date: 1951-08-23. Reporter: Clausen. Assignment: UCLA Tunnels, for Sunday, Sept. 2. 25 & 27: 3750 Horsepower steam boilers in new steam plant. D33: General view tunnel junction under life science building. D34: Same as 33, L - R: Don Crisp & M. B. Hoskins. Crisp installing phone cables. 35, 36: General view, 7 feet tunnel. D29, 30: M. B. Hoskins.21-22, 23-24: Utilities tunnel in UCLA as it leads to basement of women's gym. Bert Hoskins, assistant chief engineer of front plant, works on valve. #26: Hoskins in tunnel at bottom of new steam plant."
DOI: 10.25402/bio.22836308
title: Quantification of oxalate by novel LC–MS/MS: assay development, validation and application in lumasiran clinical trials: supplementary data

description: Background: Measurement of plasma oxalate (POx) is challenging, but critical, for management of patients
with primary hyperoxaluria type 1. A novel LC–MS/MS assay was developed, validated and used to quantify
POx in patients with primary hyperoxaluria type 1. Methods: Samples (100 μl of plasma in K2EDTA) were
spiked with internal standard (13C2-labeled oxalic acid), acidified and cleaned by protein precipitation
before analysis using anion HPLC–ESI–MS/MS. The assay was validated with a quantitation range of 0.500–
50.0 μg/ml (5.55–555 μmol/l). All parameters successfully met acceptance criteria, including 15% (20%
at lower limit of quantification) for accuracy and precision. Conclusion: This assay has advantages over
previously published POx quantitation methods, was validated in accordance with regulatory guidelines
and accurately determined POx levels in humans.
DOI: 10.25549/examiner-c44-76040
title: Examiner employees (classified), 1952

description: 2 images. Examiner employees (classified), 19 June 1952. Cleo Pat Barker; Mirth Robinson; Lou Trekas.
DOI: 10.25402/bio.23266760
title: Effect of chronopharmacology and food on in vivo pharmacokinetic profile of mavacamten: supplementary materials

description: Aim: This study investigated the impact of food intake and circadian rhythms on the pharmacokinetics of
mavacamten. Materials & methods: A sensitive bioanalytical method for quantifying mavacamten in rat
plasma was developed and validated. Thismethod was applied to assess the effect of chronopharmacology
and food intake on the pharmacokinetics of mavacamten in rats. Results: A circadian variation at two
doses resulted in significant changes in the volume of distribution, clearance and time ofmaximum plasma
concentration of mavacamten (p &lt; 0.05). In addition, food intake had an insignificant impact on the
pharmacokinetic parameters except for the time of maximum plasma concentration (p&lt;0.05). Conclusion:
These pharmacokinetic changes and human chronotype findings will help optimize dosing time.
DOI: 10.25549/examiner-c44-76090
title: Suicide, 1951

description: 5 images. Suicide, 16 September 1951. Doctor Joseph Gaynor -- 58 years (suicide); Detective E.E. Silves.; Caption slip reads: "Photographer: Lapp. Date: 1951-09-16. Reporter: Cawle. Assignment: Dr. Joseph Gaynor suicide. 39/40: Dr. Joseph Gaynor, 58, suicide, lying on bathroom floor at 1416 Havenhurst Dr. 1: Det. Sgt. E.E. Silves of Sheriff's office, examines evidence. 17/18: copy of photo victim".