cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.21505942
title: The prognostic value of peripheral ischemic microvascular reserve in sepsis is not related to calcitonin gene-related peptide or substance P

description: ABSTRACT Objective: To evaluate the mechanisms attributed to the prognostic value of peripheral ischemic microvascular reserve in patients with sepsis. Methods: This observational cohort study enrolled 46 consecutive septic patients in the intensive care unit between November 2020 and October 2021. After fluid resuscitation, the peripheral ischemic microvascular reserve was evaluated using the association of postocclusion reactive hyperemia with the peripheral perfusion index. Additionally, peripheral venous blood samples were used to evaluate the neuropeptide calcitonin gene-related peptide and substance P levels in the upper limb before and immediately after postocclusion reactive hyperemia Results: There was no statistically significant correlation (p &gt; 0.05) between basal values (pg/mL) or variations from neuropeptide levels (%) and the peripheral ischemic microvascular reserve (%). Conclusion: Although calcitonin gene-related peptide and substance P may have a prognostic role in sepsis, these neuropeptides do not appear to contribute to peripheral ischemic microvascular reserve.
DOI: 10.6084/m9.figshare.21505942.v1
title: The prognostic value of peripheral ischemic microvascular reserve in sepsis is not related to calcitonin gene-related peptide or substance P

description: ABSTRACT Objective: To evaluate the mechanisms attributed to the prognostic value of peripheral ischemic microvascular reserve in patients with sepsis. Methods: This observational cohort study enrolled 46 consecutive septic patients in the intensive care unit between November 2020 and October 2021. After fluid resuscitation, the peripheral ischemic microvascular reserve was evaluated using the association of postocclusion reactive hyperemia with the peripheral perfusion index. Additionally, peripheral venous blood samples were used to evaluate the neuropeptide calcitonin gene-related peptide and substance P levels in the upper limb before and immediately after postocclusion reactive hyperemia Results: There was no statistically significant correlation (p &gt; 0.05) between basal values (pg/mL) or variations from neuropeptide levels (%) and the peripheral ischemic microvascular reserve (%). Conclusion: Although calcitonin gene-related peptide and substance P may have a prognostic role in sepsis, these neuropeptides do not appear to contribute to peripheral ischemic microvascular reserve.
DOI: 10.6084/m9.figshare.21505943
title: Assessment of cytotoxicity, genotoxicity, and mutagenicity of the dexchlorpheniramine reference standard and pharmaceutical formula in human peripheral blood mononuclear cells

description: Abstract Dexchlorpheniramine is a first-generation classical antihistamine, clinically used to treat allergies. The main objective of our study was to evaluate the effects of the dexchlorpheniramine reference standard (DCPA Ref. St) and a pharmaceutical formula on DNA in human peripheral blood mononuclear cells (PBMCs). We exposed PBMCs to five different concentrations (0.5, 2.5, 5, 10, and 50 ng/mL) of DCPA Ref. St DCPA Ref. St and pharmaceutical formula in order to evaluate their cytotoxic, genotoxic, and mutagenic potential. The results showed that both dexchlorpheniramine formulations did not affect PBMC viability and CD3+, CD4+, or CD8+ lymphocyte subpopulations. The DCPA Ref. St and pharmaceutical formula neither induced genotoxic or mutagenic effects nor numerical or structural chromosomal alterations in PBMCs after 24 hours of exposure.
DOI: 10.6084/m9.figshare.21505943.v1
title: Assessment of cytotoxicity, genotoxicity, and mutagenicity of the dexchlorpheniramine reference standard and pharmaceutical formula in human peripheral blood mononuclear cells

description: Abstract Dexchlorpheniramine is a first-generation classical antihistamine, clinically used to treat allergies. The main objective of our study was to evaluate the effects of the dexchlorpheniramine reference standard (DCPA Ref. St) and a pharmaceutical formula on DNA in human peripheral blood mononuclear cells (PBMCs). We exposed PBMCs to five different concentrations (0.5, 2.5, 5, 10, and 50 ng/mL) of DCPA Ref. St DCPA Ref. St and pharmaceutical formula in order to evaluate their cytotoxic, genotoxic, and mutagenic potential. The results showed that both dexchlorpheniramine formulations did not affect PBMC viability and CD3+, CD4+, or CD8+ lymphocyte subpopulations. The DCPA Ref. St and pharmaceutical formula neither induced genotoxic or mutagenic effects nor numerical or structural chromosomal alterations in PBMCs after 24 hours of exposure.
DOI: 10.6084/m9.figshare.21505949
title: Incidence and risk factors for postintensive care syndrome in a cohort of critically ill patients

description: ABSTRACT Objective: To determine the incidence of postintensive care syndrome in a cohort of critically ill patients admitted to the intensive care unit and to identify risk factors related to its development in the physical, cognitive and mental health areas. Methods: This was a prospective observational cohort study developed in the intensive care unit of a university hospital. Patients with intensive care unit stays equal to or longer than one week and the need for mechanical ventilation for more than 3 days, shock or delirium were included in the study. Demographic variables, reasons for admission, diagnoses, sedation, type of mechanical ventilation used, complications and length of stay were recorded. A univariate analysis was performed to identify risk factors related to postintensive care syndrome. The scales used for the assessment of the different spheres were Barthel, Pfeiffer, Hospital Anxiety and Depression Scale and Impact of Event Scale-6. The main variables of interest were postintensive care syndrome incidence overall and by domains. Risk factors were examined in each of the health domains (physical, cognitive and mental health). Results: Eighty-seven patients were included. The mean Acute Physiology and Chronic Health Evaluation II score was 16.5. The mean number of intensive care unit days was 17. The incidence of global postintensive care syndrome was 56.3% (n = 49, 95%CI 45.8 - 66.2%). The incidence of postintensive care syndrome in each of the spheres was 32.1% (physical), 11.5% (cognitive), and 36.6% (mental health). Conclusions: The incidence of postintensive care syndrome is 56.3%. The mental health sphere is the most frequently involved. The risk factors are different depending on the area considered.
DOI: 10.6084/m9.figshare.21505949.v1
title: Incidence and risk factors for postintensive care syndrome in a cohort of critically ill patients

description: ABSTRACT Objective: To determine the incidence of postintensive care syndrome in a cohort of critically ill patients admitted to the intensive care unit and to identify risk factors related to its development in the physical, cognitive and mental health areas. Methods: This was a prospective observational cohort study developed in the intensive care unit of a university hospital. Patients with intensive care unit stays equal to or longer than one week and the need for mechanical ventilation for more than 3 days, shock or delirium were included in the study. Demographic variables, reasons for admission, diagnoses, sedation, type of mechanical ventilation used, complications and length of stay were recorded. A univariate analysis was performed to identify risk factors related to postintensive care syndrome. The scales used for the assessment of the different spheres were Barthel, Pfeiffer, Hospital Anxiety and Depression Scale and Impact of Event Scale-6. The main variables of interest were postintensive care syndrome incidence overall and by domains. Risk factors were examined in each of the health domains (physical, cognitive and mental health). Results: Eighty-seven patients were included. The mean Acute Physiology and Chronic Health Evaluation II score was 16.5. The mean number of intensive care unit days was 17. The incidence of global postintensive care syndrome was 56.3% (n = 49, 95%CI 45.8 - 66.2%). The incidence of postintensive care syndrome in each of the spheres was 32.1% (physical), 11.5% (cognitive), and 36.6% (mental health). Conclusions: The incidence of postintensive care syndrome is 56.3%. The mental health sphere is the most frequently involved. The risk factors are different depending on the area considered.
DOI: 10.6084/m9.figshare.21505951
title: Mechanisms involved in the biocontrol of rice sheath blight by Waitea circinata

description: ABSTRACT The BRS Tropical rice cultivar was developed for tropical foodplains, but is susceptible to sheath blight, making the Waitea circinata bioagent an important tool in managing the disease. This study aimed to assess the W. circinata mechanisms involved in the parasitism and resistance induction to sheath blight. The in vitro antagonism was assessed by optical microscopy and scanning electron microscopy, followed by quantification of the lytic enzymes involved in parasitism, such as chitinase, glucanase and protease. An effect of the W. circinata mycoparasite against Rhizoctonia solani was observed. The W. circinata application suppressed the sheath blight by up to 65 % and increased the chitinase, glucanase and lipoxygenase activity 72 h after the inoculation and that of the peroxidase 96 h after the inoculation. Thus, W. circinata showed to be efficient in suppressing sheath blight by parasitism and induced resistance via the activation of biochemical mechanisms.
DOI: 10.6084/m9.figshare.21505951.v1
title: Mechanisms involved in the biocontrol of rice sheath blight by Waitea circinata

description: ABSTRACT The BRS Tropical rice cultivar was developed for tropical foodplains, but is susceptible to sheath blight, making the Waitea circinata bioagent an important tool in managing the disease. This study aimed to assess the W. circinata mechanisms involved in the parasitism and resistance induction to sheath blight. The in vitro antagonism was assessed by optical microscopy and scanning electron microscopy, followed by quantification of the lytic enzymes involved in parasitism, such as chitinase, glucanase and protease. An effect of the W. circinata mycoparasite against Rhizoctonia solani was observed. The W. circinata application suppressed the sheath blight by up to 65 % and increased the chitinase, glucanase and lipoxygenase activity 72 h after the inoculation and that of the peroxidase 96 h after the inoculation. Thus, W. circinata showed to be efficient in suppressing sheath blight by parasitism and induced resistance via the activation of biochemical mechanisms.
DOI: 10.6084/m9.figshare.21505952
title: Clinical and epidemiological characteristics and individual experiences of illness in men with COVID-19: mixed method study

description: ABSTRACT BACKGROUND: Since the beginning of the coronavirus disease 2019 (COVID-19) pandemic, studies have shown that this disease has affected the male population on a significant scale in various parts of the world, making men one of the main risk groups. OBJECTIVE: To analyze the clinical and epidemiological characteristics and experiences of illness in men with COVID-19. DESIGN AND SETTING: A mixed sequential-explanatory study with cross-sectional and exploratory-descriptive approaches. METHOD: Data was collected from a small municipality located in the central-north region of the state of Bahia, Brazil. Primary quantitative data was extracted from compulsory notification forms from 598 men. Qualitative data from individual interviews of 30 men was analyzed by the Discourse of the Collective Subject method. RESULTS: The findings identified the characterization of reports of suspected and confirmed cases of COVID-19 in men, the organization of the healthcare system, and strategies for the control and combat of COVID-19 directed towards the men of the investigated municipality. They revealed the clinical characteristics based on the collective discourse of men with COVID-19. CONCLUSION: In men, the individual experience of disease explicitly explains the clinical markers of COVID-19 expressed by the self-reported syndromic approach. Additionally, this understanding also explains the behaviors observed in their search for health care, as well as the adoption of prevention and control measures and therapies recommended by health professionals.
DOI: 10.6084/m9.figshare.21505952.v1
title: Clinical and epidemiological characteristics and individual experiences of illness in men with COVID-19: mixed method study

description: ABSTRACT BACKGROUND: Since the beginning of the coronavirus disease 2019 (COVID-19) pandemic, studies have shown that this disease has affected the male population on a significant scale in various parts of the world, making men one of the main risk groups. OBJECTIVE: To analyze the clinical and epidemiological characteristics and experiences of illness in men with COVID-19. DESIGN AND SETTING: A mixed sequential-explanatory study with cross-sectional and exploratory-descriptive approaches. METHOD: Data was collected from a small municipality located in the central-north region of the state of Bahia, Brazil. Primary quantitative data was extracted from compulsory notification forms from 598 men. Qualitative data from individual interviews of 30 men was analyzed by the Discourse of the Collective Subject method. RESULTS: The findings identified the characterization of reports of suspected and confirmed cases of COVID-19 in men, the organization of the healthcare system, and strategies for the control and combat of COVID-19 directed towards the men of the investigated municipality. They revealed the clinical characteristics based on the collective discourse of men with COVID-19. CONCLUSION: In men, the individual experience of disease explicitly explains the clinical markers of COVID-19 expressed by the self-reported syndromic approach. Additionally, this understanding also explains the behaviors observed in their search for health care, as well as the adoption of prevention and control measures and therapies recommended by health professionals.
DOI: 10.6084/m9.figshare.21505955
title: Cryptanthus euglossinii (Bromeliaceae: Bromelioideae), a new species from Chapada Diamantina, Bahia

description: Abstract A new species of Cryptanthus, known exclusively from Chapada Diamantina, in the municipalities of Miguel Calmon and Jacobina, state of Bahia, Northeast Brazil, is described and illustrated. Cryptanthus euglossinii is characterized by having leaves that are reddish in the marginal region, white-scaly near the base and glabrous adaxially towards the apex, with the abaxial surface covered by trichomes that obscure the color of the leaf. Comparisons are made with two similar species, C. reisii and C. bibarrensis, that are considered closely related. Euglossinii bees were observed visiting the flowers of C. euglossinii and collecting floral essences on petals, a relationship that is the basis of the epithet of the new species. Cryptanthus euglossinii is considered Endangered (EN) based on an extent of occurrence of 860 km2, an area of occupancy of 1,000 km2, and criteria established by the IUCN.
DOI: 10.6084/m9.figshare.21505955.v1
title: Cryptanthus euglossinii (Bromeliaceae: Bromelioideae), a new species from Chapada Diamantina, Bahia

description: Abstract A new species of Cryptanthus, known exclusively from Chapada Diamantina, in the municipalities of Miguel Calmon and Jacobina, state of Bahia, Northeast Brazil, is described and illustrated. Cryptanthus euglossinii is characterized by having leaves that are reddish in the marginal region, white-scaly near the base and glabrous adaxially towards the apex, with the abaxial surface covered by trichomes that obscure the color of the leaf. Comparisons are made with two similar species, C. reisii and C. bibarrensis, that are considered closely related. Euglossinii bees were observed visiting the flowers of C. euglossinii and collecting floral essences on petals, a relationship that is the basis of the epithet of the new species. Cryptanthus euglossinii is considered Endangered (EN) based on an extent of occurrence of 860 km2, an area of occupancy of 1,000 km2, and criteria established by the IUCN.
DOI: 10.6084/m9.figshare.21505958
title: Evaluation of pediatric patients presenting with acute-onset unilateral transient acquired blepharoptosis

description: ABSTRACT Purpose: To evaluate the clinical features of pediatric patients with acute-onset, unilateral transient acquired blepharoptosis. Methods: In this retrospective study, the clinical records of patients between April 2015 and June 2020 were reviewed for evaluation of demographic features, accompanying neurological and ophthalmologic manifestations, symptom duration, etiological cause, and imaging findings. Patients with congenital and acquired blepharoptosis with chronic etiologies were excluded. Results: Sixteen pediatric patients (10 boys and 6 girls) with acquired acute-onset unilateral transient blepharoptosis were included in this study. The patients’ mean age was 6.93 ± 3.16 years. The most commonly identified etiological cause was trauma in 7 patients (43.75%) and infection (para-infection) in 5 patients (31.25%). In addition, Miller Fisher syndrome, Horner syndrome secondary to neuroblastoma, acquired Brown’s syndrome, and pseudotumor cerebri were identified as etiological causes in one patient each. Additional ocular findings accompanied blepharoptosis in 7 patients (58.33%). Blepharoptosis spontaneously resolved, without treatment, in all the patients, except those with Miller Fisher syndrome, neuroblastoma, and pseudotumor cerebri. None of the patients required surgical treatment and had ocular morbidities such as amblyopia. Conclusion: This study demonstrated that acute-onset unilateral transient blepharoptosis, which is rare in childhood, may regress without the need for surgical treatment in the pediatric population. However, serious pathologies that require treatment may present with blepharoptosis.
DOI: 10.6084/m9.figshare.21505958.v1
title: Evaluation of pediatric patients presenting with acute-onset unilateral transient acquired blepharoptosis

description: ABSTRACT Purpose: To evaluate the clinical features of pediatric patients with acute-onset, unilateral transient acquired blepharoptosis. Methods: In this retrospective study, the clinical records of patients between April 2015 and June 2020 were reviewed for evaluation of demographic features, accompanying neurological and ophthalmologic manifestations, symptom duration, etiological cause, and imaging findings. Patients with congenital and acquired blepharoptosis with chronic etiologies were excluded. Results: Sixteen pediatric patients (10 boys and 6 girls) with acquired acute-onset unilateral transient blepharoptosis were included in this study. The patients’ mean age was 6.93 ± 3.16 years. The most commonly identified etiological cause was trauma in 7 patients (43.75%) and infection (para-infection) in 5 patients (31.25%). In addition, Miller Fisher syndrome, Horner syndrome secondary to neuroblastoma, acquired Brown’s syndrome, and pseudotumor cerebri were identified as etiological causes in one patient each. Additional ocular findings accompanied blepharoptosis in 7 patients (58.33%). Blepharoptosis spontaneously resolved, without treatment, in all the patients, except those with Miller Fisher syndrome, neuroblastoma, and pseudotumor cerebri. None of the patients required surgical treatment and had ocular morbidities such as amblyopia. Conclusion: This study demonstrated that acute-onset unilateral transient blepharoptosis, which is rare in childhood, may regress without the need for surgical treatment in the pediatric population. However, serious pathologies that require treatment may present with blepharoptosis.
DOI: 10.6084/m9.figshare.21505961
title: Floristic structuring of woody plants from the Chaco in light of abiotic factors

description: Abstract The phytogeographic domains are structured by different geoclimatic (abiotic) factors, such as altitude, temperature and precipitation. Thus, our goal was to investigate the possible abiotic factors that are related to the floristic richness of the tree-shrub component throughout the Chaco remnants. This study is based on data of the presence and absence of species in different remnants related to geoclimatic data. In addition, World Wildlife Fund shapes were used to differentiate dry and wet Chaco. The database aggregated 36 areas and 522 species. The different clusters obtained by floristic affinity between groups in Chaco was mainly related to temperature, altitude and seasonality of precipitation. In remnants where the seasonality of precipitation and altitude were more evident, there is greater dissimilarity in the composition of the tree-shrub vegetation. On the other hand, the temperature gradient explained the floristic homogeneity in the humid Chaco. Thus, the richness of the tree-shrub component of the Chaco is mainly attributed to three geoclimatic factors. Dry Chaco presents greater floristic dissimilarity compared to Humid Chaco. Still, the seasonality of the precipitation and the altitude play a dominant role in the structuring of trees and shrubs in the Dry Chaco and the temperature in the most homogeneous formations that integrate the humid Chaco.
DOI: 10.6084/m9.figshare.21505961.v1
title: Floristic structuring of woody plants from the Chaco in light of abiotic factors

description: Abstract The phytogeographic domains are structured by different geoclimatic (abiotic) factors, such as altitude, temperature and precipitation. Thus, our goal was to investigate the possible abiotic factors that are related to the floristic richness of the tree-shrub component throughout the Chaco remnants. This study is based on data of the presence and absence of species in different remnants related to geoclimatic data. In addition, World Wildlife Fund shapes were used to differentiate dry and wet Chaco. The database aggregated 36 areas and 522 species. The different clusters obtained by floristic affinity between groups in Chaco was mainly related to temperature, altitude and seasonality of precipitation. In remnants where the seasonality of precipitation and altitude were more evident, there is greater dissimilarity in the composition of the tree-shrub vegetation. On the other hand, the temperature gradient explained the floristic homogeneity in the humid Chaco. Thus, the richness of the tree-shrub component of the Chaco is mainly attributed to three geoclimatic factors. Dry Chaco presents greater floristic dissimilarity compared to Humid Chaco. Still, the seasonality of the precipitation and the altitude play a dominant role in the structuring of trees and shrubs in the Dry Chaco and the temperature in the most homogeneous formations that integrate the humid Chaco.