cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.48597/8a37-b7s2
title: Measurement of Benz_a_anthracene at Leova

description: Measurement of Benz_a_anthracene at Leova
DOI: 10.48597/8ghn-d2kt
title: Measurement of Methanal at San Pablo de los Montes

description: Measurement of Methanal at San Pablo de los Montes
DOI: 10.48597/8w26-nap9
title: Measurement of Pyrene at Tustervatn

description: Measurement of Pyrene at Tustervatn
DOI: 10.48597/993m-jdu4
title: Measurement of Anthracene at San Lucido

description: Measurement of Anthracene at San Lucido
DOI: 10.48597/9v9z-evpf
title: Measurement of Benz_a_anthracene at Kårvatn

description: Measurement of Benz_a_anthracene at Kårvatn
DOI: 10.48597/9zqe-rdqf
title: Measurement of Pyrene at Birkenes

description: Measurement of Pyrene at Birkenes
DOI: 10.48597/a497-6qr3
title: Measurement of Pyrene at Preila

description: Measurement of Pyrene at Preila
DOI: 10.48597/a5bk-29dj
title: Measurement of Chrysene at Birkenes

description: Measurement of Chrysene at Birkenes
DOI: 10.48597/aghs-hh8g
title: Measurement of Pyrene at Zoseni

description: Measurement of Pyrene at Zoseni
DOI: 10.48597/akz4-ns63
title: Measurement of POPs (persistent organic pollutants) at Troll

description: Measurement of POPs (persistent organic pollutants) at Troll
DOI: 10.48597/araw-8whk
title: Measurement of Benz_a_anthracene at Montelibretti

description: Measurement of Benz_a_anthracene at Montelibretti
DOI: 10.48597/bcpp-arjs
title: Measurement of Pyrene at Mace Head

description: Measurement of Pyrene at Mace Head
DOI: 10.48597/bcyn-mf2w
title: Measurement of Anthracene at Montelibretti

description: Measurement of Anthracene at Montelibretti
DOI: 10.48597/bfxs-z8u3
title: Measurement of Precipitation_amount_off at Vorhegg

description: Measurement of Precipitation_amount_off at Vorhegg
DOI: 10.48597/c3nx-ypvg
title: Measurement of Benz_a_anthracene at Malin Head

description: Measurement of Benz_a_anthracene at Malin Head
DOI: 10.48597/cgbk-mupa
title: Measurement of Anthracene at Karasjok

description: Measurement of Anthracene at Karasjok
DOI: 10.48597/czsp-axkf
title: Measurement of Beta_HCH at Troll

description: Measurement of Beta_HCH at Troll
DOI: 10.48597/d7rv-k8gp
title: Measurement of Chrysene at Ispra

description: Measurement of Chrysene at Ispra
DOI: 10.48597/dx5q-pqpj
title: Measurement of Pyrene at Kårvatn

description: Measurement of Pyrene at Kårvatn
DOI: 10.48597/e2mm-uwns
title: Measurement of Benz_a_anthracene at Giordan Lighthouse

description: Measurement of Benz_a_anthracene at Giordan Lighthouse
DOI: 10.6084/m9.figshare.18838361
title: Source Data for main article.xlsx

description: Immunohistochemistry
(IHC) was visualized by using an automatic multispectral imaging system with
associated software (Vectra II, PerkinElmer, version 2.0.7.1). The size and
zeta potential of HLPC and M@HLPC were measured by using a nanoparticle
tracking analysis (NTA, Particle Metrix, Germany, version 8.05.04). The
absorbance was measured by automatic microplate reader with associated software
(Tecan Infinite M200, version 1.6.19.2). The interaction between each
sub-component in HLPC were measured by microscale thermophoresis (MST, NT.115,
Nanotemper, Germany). Flow cytometry data was acquired with Backman CytoFLEX LX
Flow Cytometer with associated software (version 2.3.1.22). The biodistribution
of nanoparticles were observed by using IVIS imaging system (PerkinElmer, USA,
version 4.5.5). 

Power analysis of the animal experiments
indicated that the chosen sample sizes per group are sufficient. We also
referred to relevant literature to determine sample sizes. For the in vitro and
in vivo experiments, we followed standards of good scientific practice. We used
at least 3 biological replicates or 3 animals per group, to calculate means and
standard deviations and to perform statistical analyses.

Statistical analyses were performed using
GraphPad Prism 8.0. Data were analyzed by two-tailed unpaired Student’s t-tests
(two groups) or One-way ANOVA (multiple-groups). P values less than 0.05 were
considered statistically significant.
DOI: 10.48597/e44j-vxe6
title: Measurement of Benz_a_anthracene at Kollumerwaard

description: Measurement of Benz_a_anthracene at Kollumerwaard
DOI: 10.48597/eck7-jzvp
title: Measurement of Benz_a_anthracene at Longobucco

description: Measurement of Benz_a_anthracene at Longobucco
DOI: 10.48597/efsa-t2db
title: Measurement of Benz_a_anthracene at Mace Head

description: Measurement of Benz_a_anthracene at Mace Head
DOI: 10.48597/fe4r-mmcf
title: Measurement of Anthracene at Giordan Lighthouse

description: Measurement of Anthracene at Giordan Lighthouse
DOI: 10.48597/g22r-mts9
title: Measurement of Anthracene at Preila

description: Measurement of Anthracene at Preila
DOI: 10.48597/gext-f53m
title: Measurement of Precipitation_amount_off at Zoebelboden

description: Measurement of Precipitation_amount_off at Zoebelboden
DOI: 10.48597/ggfc-gfsp
title: Measurement of Ethanal at San Pablo de los Montes

description: Measurement of Ethanal at San Pablo de los Montes
DOI: 10.48597/ggrq-nh2n
title: Measurement of Anthracene at Hurdal

description: Measurement of Anthracene at Hurdal
DOI: 10.48597/gvzp-sxhu
title: Measurement of POPs (persistent organic pollutants) at Troll

description: Measurement of POPs (persistent organic pollutants) at Troll
DOI: 10.48597/hdsm-dusk
title: Measurement of Benz_a_anthracene at K-puszta

description: Measurement of Benz_a_anthracene at K-puszta
DOI: 10.48597/hquq-cmjy
title: Measurement of Anthracene at Mace Head

description: Measurement of Anthracene at Mace Head
DOI: 10.48597/j78u-kgp7
title: Measurement of VOC (hydrocarbons) at San Pablo de los Montes

description: Measurement of VOC (hydrocarbons) at San Pablo de los Montes
DOI: 10.6084/m9.figshare.21929196.v1
title: human_milk_RNAseq_counts.csv.gz

description: Gene expression count matrix for milk samples
DOI: 10.48597/jsak-95uz
title: Measurement of Nitrogen oxides at Agia Marina Xyliatou / Cyprus Atmospheric Observatory

description: Measurement of Nitrogen oxides at Agia Marina Xyliatou / Cyprus Atmospheric Observatory
DOI: 10.48597/ke3r-5heu
title: Measurement of Pyrene at Longobucco

description: Measurement of Pyrene at Longobucco
DOI: 10.48597/kjzt-gyrd
title: Measurement of Chrysene at K-puszta

description: Measurement of Chrysene at K-puszta
DOI: 10.48597/mbz8-9zpt
title: Measurement of PAHs (polycyclic aromatic hydrocarbons) at Illmitz

description: Measurement of PAHs (polycyclic aromatic hydrocarbons) at Illmitz
DOI: 10.48597/mkhg-s68e
title: Measurement of VOC (carbonyls) at San Pablo de los Montes

description: Measurement of VOC (carbonyls) at San Pablo de los Montes
DOI: 10.48597/n3j8-ez25
title: Measurement of Chrysene at Leova

description: Measurement of Chrysene at Leova
DOI: 10.48597/ndj3-ssu4
title: Measurement of Benz_a_anthracene at Preila

description: Measurement of Benz_a_anthracene at Preila
DOI: 10.48597/njf2-dhwa
title: Measurement of Anthracene at Kollumerwaard

description: Measurement of Anthracene at Kollumerwaard
DOI: 10.48597/nm4m-7g7v
title: Measurement of Chlordane at Troll

description: Measurement of Chlordane at Troll
DOI: 10.48597/p2sg-qg7y
title: Measurement of Precipitation_amount_off at Illmitz

description: Measurement of Precipitation_amount_off at Illmitz
DOI: 10.48597/pn3p-5dn9
title: Measurement of Pyrene at K-puszta

description: Measurement of Pyrene at K-puszta
DOI: 10.48597/pqsa-uz63
title: Measurement of Chrysene at Tustervatn

description: Measurement of Chrysene at Tustervatn
DOI: 10.48597/qjrr-kym2
title: Measurement of Chrysene at Malin Head

description: Measurement of Chrysene at Malin Head
DOI: 10.48597/r96n-fmsa
title: Measurement of POPs (persistent organic pollutants) at Troll

description: Measurement of POPs (persistent organic pollutants) at Troll
DOI: 10.48597/rcjw-y4yw
title: Measurement of Pyrene at Storhofdi

description: Measurement of Pyrene at Storhofdi
DOI: 10.48597/rz5s-ezbj
title: Measurement of Benz_a_anthracene at Zeppelin mountain (Ny-Ålesund)

description: Measurement of Benz_a_anthracene at Zeppelin mountain (Ny-Ålesund)
DOI: 10.48597/s3z7-zc29
title: Measurement of Chrysene at Kårvatn

description: Measurement of Chrysene at Kårvatn
DOI: 10.48597/swjg-rhmz
title: Measurement of Benz_a_anthracene at Karasjok

description: Measurement of Benz_a_anthracene at Karasjok
DOI: 10.48597/t3fp-d2n8
title: Measurement of Anthracene at Rugsteliskis

description: Measurement of Anthracene at Rugsteliskis
DOI: 10.48597/t7am-sn94
title: Measurement of Chrysene at Preila

description: Measurement of Chrysene at Preila
DOI: 10.48597/t92p-k8gz
title: Measurement of Pyrene at Zeppelin mountain (Ny-Ålesund)

description: Measurement of Pyrene at Zeppelin mountain (Ny-Ålesund)
DOI: 10.48597/tdgb-avb9
title: Measurement of Benz_a_anthracene at Borovoe

description: Measurement of Benz_a_anthracene at Borovoe
DOI: 10.48597/txcq-6a3t
title: Measurement of Pyrene at Rugsteliskis

description: Measurement of Pyrene at Rugsteliskis
DOI: 10.48597/tyzc-rmrq
title: Measurement of Chrysene at Rucava

description: Measurement of Chrysene at Rucava
DOI: 10.48597/u5b6-yng2
title: Measurement of Pyrene at Montelibretti

description: Measurement of Pyrene at Montelibretti
DOI: 10.48597/u65h-gj9z
title: Measurement of Benz_a_anthracene at San Lucido

description: Measurement of Benz_a_anthracene at San Lucido
DOI: 10.6084/m9.figshare.21918891
title: human_milk_cis_eQTL_summary_stats.tab.gz.tbi

description: Index file for human milk eQTL summary statistics in tabix format
DOI: 10.6084/m9.figshare.21918891.v1
title: human_milk_cis_eQTL_summary_stats.tab.gz.tbi

description: Index file for human milk eQTL summary statistics in tabix format
DOI: 10.6084/m9.figshare.25321102
title: Sample Collection Frequency in Running

description: A pilot study revealed subtle discrepancies between the frequencies of 60Hz and 120Hz. This finding suggests that, although perceptible variations exist, the difference between the two frequencies is not significant enough to justify opting for 120Hz over 60Hz for the operation in question. Data collection was synchronized using two setups connected through OpenCAP. Processing was conducted through a Python routine.
DOI: 10.48597/u9b7-vz88
title: Measurement of Anthracene at Borovoe

description: Measurement of Anthracene at Borovoe
DOI: 10.48597/uc8j-q7pc
title: Measurement of Pyrene at San Lucido

description: Measurement of Pyrene at San Lucido
DOI: 10.48597/ug84-5n3j
title: Measurement of Benz_a_anthracene at Zoseni

description: Measurement of Benz_a_anthracene at Zoseni
DOI: 10.48597/ugm5-pg67
title: Measurement of Pyrene at Malin Head

description: Measurement of Pyrene at Malin Head
DOI: 10.48597/uhwe-st4f
title: Measurement of Precipitation_amount_off at Danum Valley

description: Measurement of Precipitation_amount_off at Danum Valley
DOI: 10.48597/um2u-vexw
title: Measurement of Pm10_mass at Vorhegg

description: Measurement of Pm10_mass at Vorhegg
DOI: 10.48597/uz4t-vxxk
title: Measurement of Anthracene at Longobucco

description: Measurement of Anthracene at Longobucco
DOI: 10.48597/v3pr-u9bh
title: Measurement of Anthracene at Malin Head

description: Measurement of Anthracene at Malin Head
DOI: 10.48597/va7b-5snm
title: Measurement of Pyrene at Leova

description: Measurement of Pyrene at Leova
DOI: 10.48597/vbpv-nswm
title: Measurement of Pyrene at Borovoe

description: Measurement of Pyrene at Borovoe
DOI: 10.48597/vjg3-h9jn
title: Measurement of Pyrene at Rucava

description: Measurement of Pyrene at Rucava
DOI: 10.48597/w4xj-mfkx
title: Measurement of VOC (hydrocarbons) at San Pablo de los Montes

description: Measurement of VOC (hydrocarbons) at San Pablo de los Montes
DOI: 10.48597/w8tm-rups
title: Measurement of VOC (hydrocarbons) at San Pablo de los Montes

description: Measurement of VOC (hydrocarbons) at San Pablo de los Montes
DOI: 10.48597/wc5c-y93k
title: Measurement of Anthracene at Storhofdi

description: Measurement of Anthracene at Storhofdi
DOI: 10.48597/wsky-tdgs
title: Measurement of Pyrene at Carnsore Point

description: Measurement of Pyrene at Carnsore Point
DOI: 10.48597/ww2t-ue3u
title: Measurement of Inorganics in air and particle phase at Doñana

description: Measurement of Inorganics in air and particle phase at Doñana
DOI: 10.48597/x4bk-bv94
title: Measurement of Anthracene at Rucava

description: Measurement of Anthracene at Rucava
DOI: 10.48597/x6yr-be5x
title: Measurement of Benz_a_anthracene at Storhofdi

description: Measurement of Benz_a_anthracene at Storhofdi
DOI: 10.48597/x7dj-8rzm
title: Measurement of Chrysene at Zoseni

description: Measurement of Chrysene at Zoseni
DOI: 10.48597/x7qq-yshs
title: Measurement of Benz_a_anthracene at Rucava

description: Measurement of Benz_a_anthracene at Rucava
DOI: 10.48597/xffg-j44r
title: Measurement of Chrysene at San Lucido

description: Measurement of Chrysene at San Lucido
DOI: 10.48597/y7nw-fz87
title: Measurement of Pyrene at Kollumerwaard

description: Measurement of Pyrene at Kollumerwaard
DOI: 10.48597/z4sc-5k3p
title: Measurement of Chrysene at Zeppelin mountain (Ny-Ålesund)

description: Measurement of Chrysene at Zeppelin mountain (Ny-Ålesund)
DOI: 10.48597/z8ks-u5hx
title: Measurement of Chrysene at Rugsteliskis

description: Measurement of Chrysene at Rugsteliskis
DOI: 10.48597/2j2w-3ycc
title: Cis_NO at Keldsnor

description: Measurement of Cis_NO at Keldsnor
DOI: 10.48597/2ntt-c3bp
title: Trans_CD at Tange

description: Measurement of Trans_CD at Tange
DOI: 10.48597/38eq-drj3
title: Benzo_a_pyrene at Keldsnor

description: Measurement of Benzo_a_pyrene at Keldsnor
DOI: 10.48597/397x-efqx
title: Fluorene at Anholt

description: Measurement of Fluorene at Anholt
DOI: 10.48597/3th4-u5qu
title: Gamma_HCH at Zingst

description: Measurement of Gamma_HCH at Zingst
DOI: 10.48597/474n-5s8z
title: Pp_DDT at Tange

description: Measurement of Pp_DDT at Tange
DOI: 10.48597/47cd-s5sr
title: Pp_DDE at Anholt

description: Measurement of Pp_DDE at Anholt
DOI: 10.48597/4f68-b9hh
title: Phenanthrene at Anholt

description: Measurement of Phenanthrene at Anholt
DOI: 10.48597/4pwe-j5e9
title: Pp_DDE at Keldsnor

description: Measurement of Pp_DDE at Keldsnor
DOI: 10.48597/4w3d-7t9h
title: Gamma_HCH at Keldsnor

description: Measurement of Gamma_HCH at Keldsnor
DOI: 10.48597/5waq-5hp8
title: Fluorene at Tange

description: Measurement of Fluorene at Tange
DOI: 10.48597/5xdb-f7vt
title: Fluorene at Keldsnor

description: Measurement of Fluorene at Keldsnor
DOI: 10.48597/6pm6-zp2y
title: Pp_DDT at Keldsnor

description: Measurement of Pp_DDT at Keldsnor
DOI: 10.48597/6qje-4u6g
title: Pp_DDT at Schmücke

description: Measurement of Pp_DDT at Schmücke
DOI: 10.48597/7bq3-rymx
title: PCB_118 at Tange

description: Measurement of PCB_118 at Tange
DOI: 10.48597/7deg-jyfr
title: Pp_DDT at Zingst

description: Measurement of Pp_DDT at Zingst
DOI: 10.48597/7gd9-xspc
title: PCB_180 at Tange

description: Measurement of PCB_180 at Tange
DOI: 10.48597/83py-ne7q
title: PCB_180 at Anholt

description: Measurement of PCB_180 at Anholt
DOI: 10.48597/8kvt-gfvk
title: PCB_101 at Zingst

description: Measurement of PCB_101 at Zingst
DOI: 10.48597/8xpb-qxc6
title: Pp_DDD at Zingst

description: Measurement of Pp_DDD at Zingst
DOI: 10.48597/99ca-u66c
title: PCB_28 at Keldsnor

description: Measurement of PCB_28 at Keldsnor
DOI: 10.48597/9d4t-23wp
title: Beta_HCH at Keldsnor

description: Measurement of Beta_HCH at Keldsnor
DOI: 10.48597/9skd-a46p
title: PCB_52 at Anholt

description: Measurement of PCB_52 at Anholt
DOI: 10.48597/9yph-dt6y
title: PCB_101 at Keldsnor

description: Measurement of PCB_101 at Keldsnor
DOI: 10.48597/amjx-sc64
title: Trans_CD at Schmücke

description: Measurement of Trans_CD at Schmücke
DOI: 10.48597/aykk-ekt4
title: Phenanthrene at Tange

description: Measurement of Phenanthrene at Tange
DOI: 10.6084/m9.figshare.13070896
title: Additional file 1 of Application of compound material alleviates saline and alkaline stress in cotton leaves through regulation of the transcriptome

description: Additional file 1: Table S1. Statistical analyses and mapping results of RNA sequencing reads. Table S2. Primers used in qRT-PCR analysis.
DOI: 10.48597/b7dk-a57h
title: Pp_DDE at Schmücke

description: Measurement of Pp_DDE at Schmücke
DOI: 10.6084/m9.figshare.7828370.v8
title: <i>Inonotus obliquus</i> polysaccharide ameliorates dextran sulphate sodium induced colitis involving modulation of Th1/Th2 and Th17/Treg balance

description: Inflammatory bowel disease (IBD) is an intestinal chronic inflammatory disease, and is related to imbalance of CD4<sup>+</sup>T subsets. However, the current treatments of chronic colitis are not ideal and have potential side effects. Therefore, more effective and safer biologically active substances which are extracted from natural plants have been widely concerned. In this study, it was found that <i>Inonotus obliquus</i> polysaccharides (IOP), the main bioactive constituent of <i>Inonotus obliquus</i>, can alleviate dextran sodium sulfate-induced chronic murine intestinal inflammation. Oral administration of IOP (100, 200, 300 mg/kg) can significantly reduce the disease active index and alleviate the pathological changes in colitis mice, where the tight junction proteins Occludin and ZO-1 losses in colon tissues were reduced. It can also regulate imbalanced Th1/Th2 and Th17/Treg in colon tissues, mesenteric lymph nodes and spleen using Reverse Transcription-Polymerase Chain Reaction detection and flow cytometry. Immunohistochemistry and western blot assays further revealed the modulatory effect of IOP on the p-STAT1, p-STAT6, p-STAT3 expression, which promoted the balance of Th1/Th2, Th17/Treg in the colon of chronic colitis mice. In short, these results indicated that IOP was potentially effective therapeutic agent for IBD.
DOI: 10.48597/bbjp-w25m
title: Pp_DDE at Zingst

description: Measurement of Pp_DDE at Zingst
DOI: 10.48597/bc6b-48ur
title: Beta_HCH at Tange

description: Measurement of Beta_HCH at Tange
DOI: 10.6084/m9.figshare.7828370.v14
title: <i>Inonotus obliquus</i> polysaccharide ameliorates dextran sulphate sodium induced colitis involving modulation of Th1/Th2 and Th17/Treg balance

description: Inflammatory bowel disease (IBD) is an intestinal chronic inflammatory disease, and is related to imbalance of CD4<sup>+</sup>T subsets. However, the current treatments of chronic colitis are not ideal and have potential side effects. Therefore, more effective and safer biologically active substances which are extracted from natural plants have been widely concerned. In this study, it was found that <i>Inonotus obliquus</i> polysaccharides (IOP), the main bioactive constituent of <i>Inonotus obliquus</i>, can alleviate dextran sodium sulfate-induced chronic murine intestinal inflammation. Oral administration of IOP (100, 200, 300 mg/kg) can significantly reduce the disease active index and alleviate the pathological changes in colitis mice, where the tight junction proteins Occludin and ZO-1 losses in colon tissues were reduced. It can also regulate imbalanced Th1/Th2 and Th17/Treg in colon tissues, mesenteric lymph nodes and spleen using Reverse Transcription-Polymerase Chain Reaction detection and flow cytometry. Immunohistochemistry and western blot assays further revealed the modulatory effect of IOP on the p-STAT1, p-STAT6, p-STAT3 expression, which promoted the balance of Th1/Th2, Th17/Treg in the colon of chronic colitis mice. In short, these results indicated that IOP was potentially effective therapeutic agent for IBD.
DOI: 10.48597/bsxq-fest
title: PCB_28 at Anholt

description: Measurement of PCB_28 at Anholt
DOI: 10.48597/bvrg-n5d6
title: Cis_CD at Anholt

description: Measurement of Cis_CD at Anholt
DOI: 10.6084/m9.figshare.13070896.v1
title: Additional file 1 of Application of compound material alleviates saline and alkaline stress in cotton leaves through regulation of the transcriptome

description: Additional file 1: Table S1. Statistical analyses and mapping results of RNA sequencing reads. Table S2. Primers used in qRT-PCR analysis.
DOI: 10.48597/c5w9-6dnz
title: Gamma_HCH at Anholt

description: Measurement of Gamma_HCH at Anholt
DOI: 10.48597/cgda-9jtd
title: PCB_138 at Anholt

description: Measurement of PCB_138 at Anholt
DOI: 10.6084/m9.figshare.7828370.v16
title: <i>Inonotus obliquus</i> polysaccharide ameliorates dextran sulphate sodium induced colitis involving modulation of Th1/Th2 and Th17/Treg balance

description: Inflammatory bowel disease (IBD) is an intestinal chronic inflammatory disease, and is related to imbalance of CD4<sup>+</sup>T subsets. However, the current treatments of chronic colitis are not ideal and have potential side effects. Therefore, more effective and safer biologically active substances which are extracted from natural plants have been widely concerned. In this study, it was found that <i>Inonotus obliquus</i> polysaccharides (IOP), the main bioactive constituent of <i>Inonotus obliquus</i>, can alleviate dextran sodium sulfate-induced chronic murine intestinal inflammation. Oral administration of IOP (100, 200, 300 mg/kg) can significantly reduce the disease active index and alleviate the pathological changes in colitis mice, where the tight junction proteins Occludin and ZO-1 losses in colon tissues were reduced. It can also regulate imbalanced Th1/Th2 and Th17/Treg in colon tissues, mesenteric lymph nodes and spleen using Reverse Transcription-Polymerase Chain Reaction detection and flow cytometry. Immunohistochemistry and western blot assays further revealed the modulatory effect of IOP on the p-STAT1, p-STAT6, p-STAT3 expression, which promoted the balance of Th1/Th2, Th17/Treg in the colon of chronic colitis mice. In short, these results indicated that IOP was potentially effective therapeutic agent for IBD.
DOI: 10.6084/m9.figshare.7828370.v18
title: <i>Inonotus obliquus</i> polysaccharide ameliorates dextran sulphate sodium induced colitis involving modulation of Th1/Th2 and Th17/Treg balance

description: Inflammatory bowel disease (IBD) is an intestinal chronic inflammatory disease, and is related to imbalance of CD4<sup>+</sup>T subsets. However, the current treatments of chronic colitis are not ideal and have potential side effects. Therefore, more effective and safer biologically active substances which are extracted from natural plants have been widely concerned. In this study, it was found that <i>Inonotus obliquus</i> polysaccharides (IOP), the main bioactive constituent of <i>Inonotus obliquus</i>, can alleviate dextran sodium sulfate-induced chronic murine intestinal inflammation. Oral administration of IOP (100, 200, 300 mg/kg) can significantly reduce the disease active index and alleviate the pathological changes in colitis mice, where the tight junction proteins Occludin and ZO-1 losses in colon tissues were reduced. It can also regulate imbalanced Th1/Th2 and Th17/Treg in colon tissues, mesenteric lymph nodes and spleen using Reverse Transcription-Polymerase Chain Reaction detection and flow cytometry. Immunohistochemistry and western blot assays further revealed the modulatory effect of IOP on the p-STAT1, p-STAT6, p-STAT3 expression, which promoted the balance of Th1/Th2, Th17/Treg in the colon of chronic colitis mice. In short, these results indicated that IOP was potentially effective therapeutic agent for IBD.
DOI: 10.48597/cpvs-bssm
title: Op_DDT at Keldsnor

description: Measurement of Op_DDT at Keldsnor