cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.7102175.v1
title: Evaluation of anterior segment parameters in patients with pseudoexfoliation syndrome using Scheimpflug imaging

description: ABSTRACT Purpose: To evaluate anterior segment parameters in patients with pseudoexfoliation syndrome (PXS) using Scheimpflug imaging. Methods: Forty-three PXS patients and 43 healthy control subjects were included in this cross-sectional study. All participants underwent a detailed ophthalmologic examination. Anterior segment parameters were measured using a Scheimpflug system. Results: Considering the PXS and control groups, the mean corneal thicknesses at the apex point (536 ± 31 and 560 ± 31 µm, respectively, p=0.001), at the center of the pupil (534 ± 31 and 558 ± 33 µm, respectively, p=0.001), and at the thinnest point (528 ± 30 and 546 ± 27 µm, respectively, p=0.005) were significantly thinner in PXS patients. Visual acuity was significantly lower (0.52 ± 0.37 versus 0.88 ± 0.23, p&lt;0.001) and axial length was significantly longer (23.9 ± 0.70 mm versus 23.2 ± 0.90 mm, p=0.001) in the PXS eyes than in the control eyes. There were no statistically significant differences in the mean values of keratometry, anterior chamber angle, anterior chamber depth, corneal volume, and anterior chamber volume between the PXS and control eyes. Conclusions: The patients with PXS had thinner corneas, worse visual acuity, and longer axial length compared with those in the healthy controls.
DOI: 10.6084/m9.figshare.7102163
title: PHYSICAL ACTIVITY, CARDIORESPIRATORY FITNESS AND METABOLIC SYNDROME IN ADOLESCENTS

description: ABSTRACT Introduction: Metabolic Syndrome (MetS) has been associated with sedentary behavior, low levels of physical activity and of cardiorespiratory fitness. However, in adolescents the results are conflicting. Objective: To measure the association between sedentary behavior, physical activity, cardiorespiratory fitness and MetS in a representative sample of adolescents. Methods: The sample consisted of 1,035 adolescents (565 girls and 470 boys) between 12 and 20 years of age. Sedentary behavior was treated through recreational screen time, while information equivalent to physical activity was considered through the Physical Activity Questionnaire for Adolescents. The maximal oxygen uptake (VO2max), estimated through PACER performance, was used as an indicator of cardiorespiratory fitness. MetS was identified using the criteria of the International Diabetes Federation. Results: Adolescents of both sexes identified with MetS had significantly longer recreational screen time and lower VO2max than their unidentified MetS peers. Scores equivalent to the level of physical activity undertaken by adolescents identified and not identified with MetS were statistically similar. Probabilistically, adolescents with high recreational screen time and low VO2max had, respectively, 79% [OR = 1.79; 95% CI 1.10 – 2.82] and 95% [OR = 1.95; 95% CI 1.20 – 3.09] greater odds of being identified with MetS. Conclusion: The findings indicate consistent and significant associations between longer recreational screen time, low VO2max values and high prevalence of MetS, which suggests specific interventions designed to help minimize cardiometabolic risk exposure from a very early age. Level of Evidence III; Prognostic Studies - Investigating the Effect of a Patient's Characteristics on the Disease Outcome.
DOI: 10.6084/m9.figshare.7102160
title: Therapeutic effects of proanthocyanidin and coenzyme Q10 on nitrogen mustard-induced ocular injury

description: ABSTRACT Purpose: Nitrogen mustard (NM) is a devastating casualty agent in chemical warfare. There is no effective antidote to treat NM-induced ocular injury. We aimed to assess the effects of proanthocyanidin (PAC) and coenzyme Q10 (CoQ10) on NM-induced ocular injury. Methods: Eighteen male rats were divided into the following 4 groups: NM, NM + PAC, NM + CoQ10, and control. The 3 NM groups received a single dose of NM (0.02 mg/μL) on the right eye to induce ocular injury. The control group received saline only. Thirty minutes after the application of NM, the NM + PAC group received PAC (100 mg/kg) via gastric gavage, while the NM + CoQ10 group received CoQ10 (10 mg/kg) via intraperitoneal injection. PAC and CoQ10 were administered once a day for 5 consecutive days. The rats were then sacrificed. Macroscopic images of the eyes were examined and eye tissues were collected for histology. Results: The treatment groups were compared to the control group with regard to both corneal opacity and lid injury scores. The findings were not significantly different for both the NM + PAC and NM + CoQ10 groups. In both the NM + PAC and NM + CoQ10 groups, the histological changes seen in the NM group demonstrated improvement. Conclusions: Our results indicate that PAC and CoQ10 treatments have therapeutic effects on NM-induced ocular injury in a rat model. PAC and CoQ10 may be novel options in patients with NM-induced ocular injury.
DOI: 10.6084/m9.figshare.7102163.v1
title: PHYSICAL ACTIVITY, CARDIORESPIRATORY FITNESS AND METABOLIC SYNDROME IN ADOLESCENTS

description: ABSTRACT Introduction: Metabolic Syndrome (MetS) has been associated with sedentary behavior, low levels of physical activity and of cardiorespiratory fitness. However, in adolescents the results are conflicting. Objective: To measure the association between sedentary behavior, physical activity, cardiorespiratory fitness and MetS in a representative sample of adolescents. Methods: The sample consisted of 1,035 adolescents (565 girls and 470 boys) between 12 and 20 years of age. Sedentary behavior was treated through recreational screen time, while information equivalent to physical activity was considered through the Physical Activity Questionnaire for Adolescents. The maximal oxygen uptake (VO2max), estimated through PACER performance, was used as an indicator of cardiorespiratory fitness. MetS was identified using the criteria of the International Diabetes Federation. Results: Adolescents of both sexes identified with MetS had significantly longer recreational screen time and lower VO2max than their unidentified MetS peers. Scores equivalent to the level of physical activity undertaken by adolescents identified and not identified with MetS were statistically similar. Probabilistically, adolescents with high recreational screen time and low VO2max had, respectively, 79% [OR = 1.79; 95% CI 1.10 – 2.82] and 95% [OR = 1.95; 95% CI 1.20 – 3.09] greater odds of being identified with MetS. Conclusion: The findings indicate consistent and significant associations between longer recreational screen time, low VO2max values and high prevalence of MetS, which suggests specific interventions designed to help minimize cardiometabolic risk exposure from a very early age. Level of Evidence III; Prognostic Studies - Investigating the Effect of a Patient's Characteristics on the Disease Outcome.
DOI: 10.6084/m9.figshare.7102160.v1
title: Therapeutic effects of proanthocyanidin and coenzyme Q10 on nitrogen mustard-induced ocular injury

description: ABSTRACT Purpose: Nitrogen mustard (NM) is a devastating casualty agent in chemical warfare. There is no effective antidote to treat NM-induced ocular injury. We aimed to assess the effects of proanthocyanidin (PAC) and coenzyme Q10 (CoQ10) on NM-induced ocular injury. Methods: Eighteen male rats were divided into the following 4 groups: NM, NM + PAC, NM + CoQ10, and control. The 3 NM groups received a single dose of NM (0.02 mg/μL) on the right eye to induce ocular injury. The control group received saline only. Thirty minutes after the application of NM, the NM + PAC group received PAC (100 mg/kg) via gastric gavage, while the NM + CoQ10 group received CoQ10 (10 mg/kg) via intraperitoneal injection. PAC and CoQ10 were administered once a day for 5 consecutive days. The rats were then sacrificed. Macroscopic images of the eyes were examined and eye tissues were collected for histology. Results: The treatment groups were compared to the control group with regard to both corneal opacity and lid injury scores. The findings were not significantly different for both the NM + PAC and NM + CoQ10 groups. In both the NM + PAC and NM + CoQ10 groups, the histological changes seen in the NM group demonstrated improvement. Conclusions: Our results indicate that PAC and CoQ10 treatments have therapeutic effects on NM-induced ocular injury in a rat model. PAC and CoQ10 may be novel options in patients with NM-induced ocular injury.
DOI: 10.6084/m9.figshare.7102154
title: Acute lymphoblastic leukemia presenting with bilateral serous macular detachment

description: ABSTRACT Acute lymphoblastic leukemia is a malignant hematopoietic neoplasia, which is rare in adults. Although ocular fundus alterations may be commonly observed in the course of the disease, such alterations are rarely the presenting signs of the disease. Here we describe the case of a patient with painless and progressive loss of visual acuity (right eye, 2/10; left eye, 3/10) developing over two weeks, accompanied by fever and cervical lymphadenopathy. Fundus examination showed bilateral macular serous detachment, which was confirmed by optical coherence tomography. Fluorescein angiography revealed hyperfluorescent pinpoints in the posterior poles. The limits of the macular detachment were revealed in the late phase of the angiogram. The results of blood count analysis triggered a thorough, systematic patient examination. The diagnosis of acute lymphoblastic leukemia B (CD10+) was established, and intensive systemic chemotherapy was immediately initiated. One year after the diagnosis, the patient remains in complete remission without any ophthalmologic alterations.
DOI: 10.6084/m9.figshare.7102157
title: Pachychoroid neovasculopathy in a male patient: a case report

description: ABSTRACT Pachychoroid neovasculopathy is a form of type 1 (subretinal pigment epithelium) neovascularization characterized by the involvement of dilated choroidal vessels in areas of increased choroidal thickness. This disease was originally described in three white female patients. Here we report the multimodal evaluation of a clinical case of PN in a white male patient.
DOI: 10.6084/m9.figshare.7102157.v1
title: Pachychoroid neovasculopathy in a male patient: a case report

description: ABSTRACT Pachychoroid neovasculopathy is a form of type 1 (subretinal pigment epithelium) neovascularization characterized by the involvement of dilated choroidal vessels in areas of increased choroidal thickness. This disease was originally described in three white female patients. Here we report the multimodal evaluation of a clinical case of PN in a white male patient.
DOI: 10.6084/m9.figshare.7102154.v1
title: Acute lymphoblastic leukemia presenting with bilateral serous macular detachment

description: ABSTRACT Acute lymphoblastic leukemia is a malignant hematopoietic neoplasia, which is rare in adults. Although ocular fundus alterations may be commonly observed in the course of the disease, such alterations are rarely the presenting signs of the disease. Here we describe the case of a patient with painless and progressive loss of visual acuity (right eye, 2/10; left eye, 3/10) developing over two weeks, accompanied by fever and cervical lymphadenopathy. Fundus examination showed bilateral macular serous detachment, which was confirmed by optical coherence tomography. Fluorescein angiography revealed hyperfluorescent pinpoints in the posterior poles. The limits of the macular detachment were revealed in the late phase of the angiogram. The results of blood count analysis triggered a thorough, systematic patient examination. The diagnosis of acute lymphoblastic leukemia B (CD10+) was established, and intensive systemic chemotherapy was immediately initiated. One year after the diagnosis, the patient remains in complete remission without any ophthalmologic alterations.
DOI: 10.6084/m9.figshare.7102136
title: Pupillometry in Chagas disease

description: ABSTRACT Purpose: We investigated parasympathetic innervation abnormalities of the iris sphincter and ciliary muscles in chronic Chagas disease by measuring pupillary diameter and intraocular pressure. Methods: A group of 80 patients with Chagas disease was compared with 76 healthy individuals without chagasic infection. The following procedures were performed: pupillometry, hypersensitivity test to pilocarpine 0.125%, intraocular pressure measurement (IOP), basal pupil diameter (BPD), absolute pupillary constriction amplitude (ACA), relative pupillary constriction amplitude (RCA) and the presence of anisocoria. Results: The prevalence of anisocoria was higher in chagasic patients (p&lt;0.01). These patients had mean basal pupillary diameter, mean photopic pupillary diameter and mean value of absolute pupillary constriction amplitude significantly lower than non-chagasic ones (p&lt;0.01, mean difference -0.50mm), (p=0.02, mean difference -0.20mm), (p&lt;0.01, mean difference -0.29mm), respectively. The relative pupillary constriction amplitude did not differ between the two groups (p=0.39, mean difference -1.15%). There was hypersensitivity to dilute pilocarpine in 8 (10%) of the chagasic patients in the right eye and in 2 (2.5%) in the left eye and in 1 (1.25%) in both eyes. The mean value of intraocular pressure had a marginal statistical significance between the two groups (p=0.06, mean difference -0.91mmHg). Conclusions: Patients with chagasic infection may exhibit ocular parasympathetic dysfunction, demonstrable by pupillometry and the dilute pilocarpine hypersensitivity test.
DOI: 10.6084/m9.figshare.7102136.v1
title: Pupillometry in Chagas disease

description: ABSTRACT Purpose: We investigated parasympathetic innervation abnormalities of the iris sphincter and ciliary muscles in chronic Chagas disease by measuring pupillary diameter and intraocular pressure. Methods: A group of 80 patients with Chagas disease was compared with 76 healthy individuals without chagasic infection. The following procedures were performed: pupillometry, hypersensitivity test to pilocarpine 0.125%, intraocular pressure measurement (IOP), basal pupil diameter (BPD), absolute pupillary constriction amplitude (ACA), relative pupillary constriction amplitude (RCA) and the presence of anisocoria. Results: The prevalence of anisocoria was higher in chagasic patients (p&lt;0.01). These patients had mean basal pupillary diameter, mean photopic pupillary diameter and mean value of absolute pupillary constriction amplitude significantly lower than non-chagasic ones (p&lt;0.01, mean difference -0.50mm), (p=0.02, mean difference -0.20mm), (p&lt;0.01, mean difference -0.29mm), respectively. The relative pupillary constriction amplitude did not differ between the two groups (p=0.39, mean difference -1.15%). There was hypersensitivity to dilute pilocarpine in 8 (10%) of the chagasic patients in the right eye and in 2 (2.5%) in the left eye and in 1 (1.25%) in both eyes. The mean value of intraocular pressure had a marginal statistical significance between the two groups (p=0.06, mean difference -0.91mmHg). Conclusions: Patients with chagasic infection may exhibit ocular parasympathetic dysfunction, demonstrable by pupillometry and the dilute pilocarpine hypersensitivity test.
DOI: 10.6084/m9.figshare.7102130
title: CERVICAL ENDOSCOPIC DISC SURGERY: PRECISE APPROACH FOR MINIMALLY INVASIVE DECOMPRESSION

description: ABSTRACT Objective: Technological advances in recent decades have led to a complexity of choice of the most effective method for treating cervical disc herniations. The idea of removing disc herniations using endoscope techniques is not new, and is successfully used in the treatment of lumbar disc herniations. But in the case of the cervical spine, full endoscopic procedures only started to be performed at the beginning of 2014, by Yang JS and coauthors, and their effectiveness was and still is a matter of controversy. The proposed method of endoscopic portal disc herniation removal was used for the past two years, and its results were compared with the anterior microsurgical approach using a single-level cage implantation. Methods: Twenty-five patients were included in this study, with a comparator group of 25 patients operated by ordinary anterior cervical discectomy with a single-disc fusion. All patients were operated on by the same group of surgeons. Results: During the analysis of VAS data, it was confirmed that the degree of local and radicular pain in the two groups was not significantly different (p &gt; 0.05). According to the Neck Disability Index (NDI) there was a significant difference between the two groups in relation to the endoscopic patient group. Data using the Odom criteria showed significantly better results for the endoscopic group. During the research it was observed that the patients in the endoscopically operated group were discharged from hospital more quickly, after 3 [2; 5] days compared to 5 [4; 6] days in the microsurgery group. Conclusion: The method performed is a safe and reliable alternative to convenient surgical techniques. Level of Evidenced II; Therapeutic study, investigating the results of treatment.
DOI: 10.6084/m9.figshare.7102130.v1
title: CERVICAL ENDOSCOPIC DISC SURGERY: PRECISE APPROACH FOR MINIMALLY INVASIVE DECOMPRESSION

description: ABSTRACT Objective: Technological advances in recent decades have led to a complexity of choice of the most effective method for treating cervical disc herniations. The idea of removing disc herniations using endoscope techniques is not new, and is successfully used in the treatment of lumbar disc herniations. But in the case of the cervical spine, full endoscopic procedures only started to be performed at the beginning of 2014, by Yang JS and coauthors, and their effectiveness was and still is a matter of controversy. The proposed method of endoscopic portal disc herniation removal was used for the past two years, and its results were compared with the anterior microsurgical approach using a single-level cage implantation. Methods: Twenty-five patients were included in this study, with a comparator group of 25 patients operated by ordinary anterior cervical discectomy with a single-disc fusion. All patients were operated on by the same group of surgeons. Results: During the analysis of VAS data, it was confirmed that the degree of local and radicular pain in the two groups was not significantly different (p &gt; 0.05). According to the Neck Disability Index (NDI) there was a significant difference between the two groups in relation to the endoscopic patient group. Data using the Odom criteria showed significantly better results for the endoscopic group. During the research it was observed that the patients in the endoscopically operated group were discharged from hospital more quickly, after 3 [2; 5] days compared to 5 [4; 6] days in the microsurgery group. Conclusion: The method performed is a safe and reliable alternative to convenient surgical techniques. Level of Evidenced II; Therapeutic study, investigating the results of treatment.
DOI: 10.6084/m9.figshare.7102124
title: Evaluation of posterior ocular changes using enhanced depth imaging-optical coherence tomography in patients with obstructive sleep apnea syndrome

description: ABSTRACT Purpose: Evaluation of the nerve fiber thicknesses of the macula, choroid, and retina using the apnea-hypopnea index in individuals with obstructive sleep apnea syndrome (OSAS) without systemic components. Methods: Prospective, controlled study. The central macular, choroidal, and retinal nerve fiber layer (RNFL) thicknesses were evaluated using enhanced depth imaging-spectral domain optical coherence tomography in individuals with OSAS. In people with severe OSAS who had received treatment, posterior ocular structures were examined over 3 months (4th and 12th weeks), and changes were evaluated. Only the right eyes of the participants were evaluated in the study. Results: A total of 72 people were involved in the study, with 18 in the control group and 19 with mild, 16 with moderate, and 19 with severe OSAS. No significant difference was found among the groups in terms of demographic measures. No significant differences were found among the groups in terms of the measures of central macular, central subfoveal choroidal (CSCT), temporal choroidal, nasal choroidal, and RNFL thicknesses. In severe OSAS cases in which treatment was administered, although subjective clinical recovery was observed, statistically significant thinning was detected during the 3-month follow-up period in the CSCT, general RNFL, as well as in the inferior and superior nasal quadrants, and temporal superior quadrant (p=0.005, p=0.009, p=0.039, p=0.003, and p=0.02, respectively). Conclusion: In the group with severe OSAS, thinning in some posterior ocular tissues was observed. Although patients with severe OSAS may experience clinical recovery, we recommend that they would be followed up in terms of ocular ischemic injury.
DOI: 10.6084/m9.figshare.7102121
title: Multivariate techniques in the analysis of carcass traits of Morada Nova breed sheep

description: ABSTRACT: This study aimed to use multivariate techniques of principal component analysis and canonical discriminant analysis in a data set from Morada Nova sheep carcass to reduce the dimensions of the original data set, identify variables with the best discriminatory power among the treatments, and quantify the association between biometric and performance traits. The principal components obtained were efficient in reducing the total variation accumulated in 19 original variables correlated to five linear combinations, which explained 80% of the total variation present in the original variables. The first two principal components together accounted for 56.12% of the total variation of the evaluated variables. Eight variables were selected using the stepwise method. The first three canonical variables were significant, explaining 92.25% of the total variation. The first canonical variable showed a canonical correlation coefficient of 0.94, indicating a strong association between biometric traits and animal performance. Slaughter weight and hind width were selected because these variables presented the highest discriminatory power among all treatments, based on standard canonical coefficients.
DOI: 10.6084/m9.figshare.7102124.v1
title: Evaluation of posterior ocular changes using enhanced depth imaging-optical coherence tomography in patients with obstructive sleep apnea syndrome

description: ABSTRACT Purpose: Evaluation of the nerve fiber thicknesses of the macula, choroid, and retina using the apnea-hypopnea index in individuals with obstructive sleep apnea syndrome (OSAS) without systemic components. Methods: Prospective, controlled study. The central macular, choroidal, and retinal nerve fiber layer (RNFL) thicknesses were evaluated using enhanced depth imaging-spectral domain optical coherence tomography in individuals with OSAS. In people with severe OSAS who had received treatment, posterior ocular structures were examined over 3 months (4th and 12th weeks), and changes were evaluated. Only the right eyes of the participants were evaluated in the study. Results: A total of 72 people were involved in the study, with 18 in the control group and 19 with mild, 16 with moderate, and 19 with severe OSAS. No significant difference was found among the groups in terms of demographic measures. No significant differences were found among the groups in terms of the measures of central macular, central subfoveal choroidal (CSCT), temporal choroidal, nasal choroidal, and RNFL thicknesses. In severe OSAS cases in which treatment was administered, although subjective clinical recovery was observed, statistically significant thinning was detected during the 3-month follow-up period in the CSCT, general RNFL, as well as in the inferior and superior nasal quadrants, and temporal superior quadrant (p=0.005, p=0.009, p=0.039, p=0.003, and p=0.02, respectively). Conclusion: In the group with severe OSAS, thinning in some posterior ocular tissues was observed. Although patients with severe OSAS may experience clinical recovery, we recommend that they would be followed up in terms of ocular ischemic injury.