cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.7510139
title: Recommendations of the Neuroendocrinology Department of the Brazilian Society of Endocrinology and Metabolism for the diagnosis of Cushing’s disease in Brazil

description: ABSTRACT Although it is a rare condition, the accurate diagnosis and treatment of Cushing’s disease is important due to its higher morbidity and mortality compared to the general population, which is attributed to cardiovascular diseases, diabetes mellitus and infections. Screening for hypercortisolism is recommended for patients who present multiple and progressive clinical signs and symptoms, especially those who are considered to be more specific to Cushing’s syndrome, abnormal findings relative to age (e.g., spinal osteoporosis and high blood pressure in young patients), weight gain associated with reduced growth rate in the pediatric population and for those with adrenal incidentalomas. Routine screening is not recommended for other groups of patients, such as those with obesity or diabetes mellitus. Magnetic resonance imaging (MRI) of the pituitary, the corticotropin-releasing hormone (CRH) test and the high-dose dexamethasone suppression test are the main tests for the differential diagnosis of ACTH-dependent Cushing’s syndrome. Bilateral and simultaneous petrosal sinus sampling is the gold standard method and is performed when the triad of initial tests is inconclusive, doubtful or conflicting. The aim of this article is to provide information on the early detection and establishment of a proper diagnosis of Cushing’s disease, recommending follow-up of these patients at experienced referral centers. Arch Endocrinol Metab. 2016;60(3):267-86
DOI: 10.6084/m9.figshare.7510139.v1
title: Recommendations of the Neuroendocrinology Department of the Brazilian Society of Endocrinology and Metabolism for the diagnosis of Cushing’s disease in Brazil

description: ABSTRACT Although it is a rare condition, the accurate diagnosis and treatment of Cushing’s disease is important due to its higher morbidity and mortality compared to the general population, which is attributed to cardiovascular diseases, diabetes mellitus and infections. Screening for hypercortisolism is recommended for patients who present multiple and progressive clinical signs and symptoms, especially those who are considered to be more specific to Cushing’s syndrome, abnormal findings relative to age (e.g., spinal osteoporosis and high blood pressure in young patients), weight gain associated with reduced growth rate in the pediatric population and for those with adrenal incidentalomas. Routine screening is not recommended for other groups of patients, such as those with obesity or diabetes mellitus. Magnetic resonance imaging (MRI) of the pituitary, the corticotropin-releasing hormone (CRH) test and the high-dose dexamethasone suppression test are the main tests for the differential diagnosis of ACTH-dependent Cushing’s syndrome. Bilateral and simultaneous petrosal sinus sampling is the gold standard method and is performed when the triad of initial tests is inconclusive, doubtful or conflicting. The aim of this article is to provide information on the early detection and establishment of a proper diagnosis of Cushing’s disease, recommending follow-up of these patients at experienced referral centers. Arch Endocrinol Metab. 2016;60(3):267-86
DOI: 10.6084/m9.figshare.12171630.v1
title: Right to the water, right to the city. The universalization of sanitation in precarious urban settlements of Medellin, Colombia

description: Abstract This article analyzes a sanitation universalization program in precarious urban settlements, implemented by the municipal government of Medellin, Colombia. Based on the theory of Political Ecology, it discusses aspects that enable or restrict the expansion of sanitation services to the poor population, and analyzes the experience of Bello Oriente, a settlement not served by the program, where the population, with the support of a local NGO, has managed to improve water supply conditions and mitigate geotechnical risks. The article shows that the solution developed by the community is much closer to a concept of socioenvironmental unit than the municipal urban policy, which proposes a development based on ecological urbanism, but is subject to the neoliberal model of commodification of the city.
DOI: 10.6084/m9.figshare.7510877
title: Gender differences in insulin and C-peptide concentrations at birth using cord blood collection

description: ABSTRACT Objective To study gender differences in insulin and C-peptide concentrations at birth using cord blood collection. Subjects and methods This study was conducted in a maternity hospital, in Jammu province of Jammu and Kashmir, India. All women with pregnancy who were hospitalized for delivery were followed. All pregnant ladies who had no medical condition affecting insulin levels, as per history and routine antenatal blood testing, were included in the study. The test for cord plasma insulin and C-peptide was done in 60 (30 males) full-term (≥ 37 completed weeks) normal delivery babies within 4 hours of the collection of samples using the electro-chemiluminescence immunoassay (ECLIA) on Roche elecsys module immunoassay analyzer. Weight of the babies was taken immediately after birth using digital scales. Results Cord plasma insulin and C-peptide measured in EDTA were compared between boys and girls and also related to birth weight. Girls were lighter (2,830 ± 37 vs. 3,236 ± 46 g; p = &lt; 0.001) but had higher cord insulin (16.48 ± 4.88 vs. 10.53 ± 4.04 µU/mL; p = &lt; 0.001), and C-peptide (2.47 ± 0.66 vs. 0.834 ± 0.26 ng/mL; p = &lt; 0.001) concentrations than newborn boys. Conclusion Female newborn babies have higher cord plasma insulin and C-peptide concentrations than male newborns, despite being smaller, suggesting intrinsic insulin resistance in girls.
DOI: 10.6084/m9.figshare.7510877.v1
title: Gender differences in insulin and C-peptide concentrations at birth using cord blood collection

description: ABSTRACT Objective To study gender differences in insulin and C-peptide concentrations at birth using cord blood collection. Subjects and methods This study was conducted in a maternity hospital, in Jammu province of Jammu and Kashmir, India. All women with pregnancy who were hospitalized for delivery were followed. All pregnant ladies who had no medical condition affecting insulin levels, as per history and routine antenatal blood testing, were included in the study. The test for cord plasma insulin and C-peptide was done in 60 (30 males) full-term (≥ 37 completed weeks) normal delivery babies within 4 hours of the collection of samples using the electro-chemiluminescence immunoassay (ECLIA) on Roche elecsys module immunoassay analyzer. Weight of the babies was taken immediately after birth using digital scales. Results Cord plasma insulin and C-peptide measured in EDTA were compared between boys and girls and also related to birth weight. Girls were lighter (2,830 ± 37 vs. 3,236 ± 46 g; p = &lt; 0.001) but had higher cord insulin (16.48 ± 4.88 vs. 10.53 ± 4.04 µU/mL; p = &lt; 0.001), and C-peptide (2.47 ± 0.66 vs. 0.834 ± 0.26 ng/mL; p = &lt; 0.001) concentrations than newborn boys. Conclusion Female newborn babies have higher cord plasma insulin and C-peptide concentrations than male newborns, despite being smaller, suggesting intrinsic insulin resistance in girls.
DOI: 10.6084/m9.figshare.7514468.v1
title: Waist circumference is an effect modifier of the association between bone mineral density and glucose metabolism

description: ABSTRACT Objective: The role of bone markers on insulin resistance (IR) remains controversial. The objective of this study is to evaluate the association between bone mineral density (BMD) and glucose metabolism and investigate if visceral hyperadiposity, evaluated by waist circumference (WC), is an effect modifier of this association. Subjects and methods: Cross-sectional analysis with 468 young adults from the fourth follow-up of the 1978/79 Ribeirão Preto prospective birth cohort, Brazil. BMD, total osteocalcin (OC), fasting plasma glucose and insulin concentrations were assessed. IR, sensitivity (S) and secretion (β) were estimated by homeostasis model assessment (HOMA) indexes. Multiple linear regression models were constructed to estimate the association between BMD and glucose metabolism. Beta coefficient, R2 and p-values were provided. WC was tested as an effect modifier and OC as a confounder. The covariates were selected based on Direct Acyclic Graph. Results: Significant interaction between BMD (femoral neck and proximal femur areas) and WC on glucose metabolism was observed in the adjusted models. Subjects with increased WC presented a positive association between BMD and log HOMA1-IR while an inverse association was found in those with normal WC (femoral neck R2 = 0.17, p = 0.036; proximal femur R2 = 0.16, p = 0.086). BMD was negatively associated with log HOMA2-S in individuals with increased WC and positively in those with normal WC (femoral neck R2 = 0.16, p = 0.042; proximal femur R2 = 0.15, p = 0.097). No significant associations between BMD, log HOMA2-β and OC and glucose metabolism markers were observed. Conclusions: BMD was associated with glucose metabolism, independently of OC, and WC modifies this association.
DOI: 10.6084/m9.figshare.7514468
title: Waist circumference is an effect modifier of the association between bone mineral density and glucose metabolism

description: ABSTRACT Objective: The role of bone markers on insulin resistance (IR) remains controversial. The objective of this study is to evaluate the association between bone mineral density (BMD) and glucose metabolism and investigate if visceral hyperadiposity, evaluated by waist circumference (WC), is an effect modifier of this association. Subjects and methods: Cross-sectional analysis with 468 young adults from the fourth follow-up of the 1978/79 Ribeirão Preto prospective birth cohort, Brazil. BMD, total osteocalcin (OC), fasting plasma glucose and insulin concentrations were assessed. IR, sensitivity (S) and secretion (β) were estimated by homeostasis model assessment (HOMA) indexes. Multiple linear regression models were constructed to estimate the association between BMD and glucose metabolism. Beta coefficient, R2 and p-values were provided. WC was tested as an effect modifier and OC as a confounder. The covariates were selected based on Direct Acyclic Graph. Results: Significant interaction between BMD (femoral neck and proximal femur areas) and WC on glucose metabolism was observed in the adjusted models. Subjects with increased WC presented a positive association between BMD and log HOMA1-IR while an inverse association was found in those with normal WC (femoral neck R2 = 0.17, p = 0.036; proximal femur R2 = 0.16, p = 0.086). BMD was negatively associated with log HOMA2-S in individuals with increased WC and positively in those with normal WC (femoral neck R2 = 0.16, p = 0.042; proximal femur R2 = 0.15, p = 0.097). No significant associations between BMD, log HOMA2-β and OC and glucose metabolism markers were observed. Conclusions: BMD was associated with glucose metabolism, independently of OC, and WC modifies this association.
DOI: 10.6084/m9.figshare.7519085.v1
title: USE OF BOTANICAL INSECTICIDES AS AN ALTERNATIVE FOR THE MANAGEMENT OF THE MEXICAN BEAN WEEVIL

description: ABSTRACT: This study aimed to evaluate the insecticidal activity of eight botanical species in the behavior and biological development of Zabrotes subfasciatus (Coleoptera: Chrysomelidae: Bruchinae) under laboratory conditions. The botanical species were applied on bean grains (Phaseolus vulgaris Linnaeus) directly as powder or indirectly within TNT bags. Three laboratory assays were performed. First, a repellent activity test was performed by exposing twenty couples of Z. subfasciatus adults in a choice-test arena. Second, a mortality test was performed for seven days after infestation. Finally, the oviposition and emergency rates of adults (%) and the development from egg to adult (in days) were evaluated in seven couples (males and females) for seven days inside of a vial containing 0.3g of the powder from each botanical species and 10 g of bean grains (3% w.w-1). The study was conducted in a completely randomized design, and the treatments were arranged as a factorial design (2 x 9) with two factors (factor 1= powder and TNT bag application forms and factor 2= eight botanical species and control) with eight replications. The powder application form was more efficient in controlling Z. subfasciatus. Azadirachta indica (powder application), Ruta graveolens (powder application), and Piper aduncum (TNT bag) reduced the infestation of adults. The species A. inidica, Piper tuberculatum, Trichilia catigua, Pfaffia glomerata, R. graveolens, and Mentha pulegium inhibited the oviposition of the insects regardless of the formulation applied. R. graveolens (powder application) caused 100% of mortality. The powder application of R. graveolens and M. pulegium reduced egg viability and insect emergence; therefore, they are very promising alternatives to control Z. subfasciatus in stored grains.
DOI: 10.6084/m9.figshare.6151943.v1
title: Diagnostic relevance of spatial orientation for vascular dementia: A case study

description: ABSTRACT Spatial orientation is emerging as an early and reliable cognitive biomarker of Alzheimer’s disease (AD) pathophysiology. However, no evidence exists as to whether spatial orientation is also affected in vascular dementia (VaD). Objective: To examine allocentric (map-based) and egocentric (viewpoint-based) spatial orientation in an early stage VaD case. Methods: A spatial test battery was administered following clinical and neuropsychological cognitive evaluation. Results: Despite the patient’s complaints, little evidence of episodic memory deficits were detected when cueing was provided to overcome executive dysfunction. Similarly, medial temporal lobe-mediated allocentric orientation was intact. By contrast, medial parietal-mediated egocentric orientation was impaired, despite normal performance on standard visuospatial tasks. Conclusion: To our knowledge, this is the first in-depth investigation of spatial orientation deficits in VaD. Isolated egocentric deficits were observed. This differs from AD orientation deficits which encompass both allocentric and egocentric orientation deficits. A combination of egocentric orientation and executive function tests could serve as a promising cognitive marker for VaD pathophysiology.
DOI: 10.6084/m9.figshare.7519085
title: USE OF BOTANICAL INSECTICIDES AS AN ALTERNATIVE FOR THE MANAGEMENT OF THE MEXICAN BEAN WEEVIL

description: ABSTRACT: This study aimed to evaluate the insecticidal activity of eight botanical species in the behavior and biological development of Zabrotes subfasciatus (Coleoptera: Chrysomelidae: Bruchinae) under laboratory conditions. The botanical species were applied on bean grains (Phaseolus vulgaris Linnaeus) directly as powder or indirectly within TNT bags. Three laboratory assays were performed. First, a repellent activity test was performed by exposing twenty couples of Z. subfasciatus adults in a choice-test arena. Second, a mortality test was performed for seven days after infestation. Finally, the oviposition and emergency rates of adults (%) and the development from egg to adult (in days) were evaluated in seven couples (males and females) for seven days inside of a vial containing 0.3g of the powder from each botanical species and 10 g of bean grains (3% w.w-1). The study was conducted in a completely randomized design, and the treatments were arranged as a factorial design (2 x 9) with two factors (factor 1= powder and TNT bag application forms and factor 2= eight botanical species and control) with eight replications. The powder application form was more efficient in controlling Z. subfasciatus. Azadirachta indica (powder application), Ruta graveolens (powder application), and Piper aduncum (TNT bag) reduced the infestation of adults. The species A. inidica, Piper tuberculatum, Trichilia catigua, Pfaffia glomerata, R. graveolens, and Mentha pulegium inhibited the oviposition of the insects regardless of the formulation applied. R. graveolens (powder application) caused 100% of mortality. The powder application of R. graveolens and M. pulegium reduced egg viability and insect emergence; therefore, they are very promising alternatives to control Z. subfasciatus in stored grains.
DOI: 10.6084/m9.figshare.8091728
title: Brazilian Poison Control Centers: preliminary description of their organization and functions

description: ABSTRACT This study aimed to describe the functional and organizational attributes of Brazilian Poison Control Centers (PCC) inserted in the Urgency e Emergency Care Network of the Unified Health System (SUS). A descriptive study was conducted through an online questionnaire, made available on an electronic website and applied to professionals representing the PCC. Out of the 31 CIATox invited, 19 (61%) accepted and were included in the study. PCC offer full-time telephone and/or face-to-face care and 39 types of activities, with emphasis on clinical advice for health professionals. They are linked to management institutions at all three levels of government, however, they have limited resources, mainly due to inadequate or insufficient funding. PCC can contribute with its expertise to the visibility of intoxications in Brazil and to the development of health care practices of the exposed or intoxicated person, integrated and operationalized through health care networks.
DOI: 10.6084/m9.figshare.7507043
title: Weaning and associated factors in children from low-income communities

description: Introduction: The average duration of breastfeeding is still insufficient and differ widely taking in account the location and specific characteristic of local people involved in these studies.Aim: This research aimed at studying factors associated to weaning among South Brazilian children living in a low-income household.Material and method: Cross-sectional study was carried out enrolling 124 mothers of 1 to 12-month-old children, who were interviewed at "Pastoral da Criança" (non-governmental organization) in Almirante Tamandaré, Paraná, Brazil. The risk of weaning considered was the dependent variable and the information collected from the questionnaires, independent variables. The method used to collect information in this study was Kaplan-Meier method and Cox regression model and Spearman's rank correlation (α = 0.05).Result: Actuarial life table presented a higher weaning conditional probability at 12 months of age, followed by first and fourth months of age. Multivariate analysis pointed out that contact with bottle feeding before the sixth month of age [HR=17.16 (2.34-125.86)] and contact with pacifier before the sixth months of age [HR=3.48 (1.90-6.38)] are risk factors associated with weaning. Among children who were not breastfed at the moment of the interview, breastfeeding duration presented a positive correlation with the ages when the children had their first contact with sugar (r s=+0.419, p=0.001) and negative correlation with the use of pacifier (r s=-0.300, p=0.017).Conclusion: Results from this study showed that the use of the feeding bottle and pacifier were related to a shorter breastfeeding time span at these communities.
DOI: 10.6084/m9.figshare.8091728.v1
title: Brazilian Poison Control Centers: preliminary description of their organization and functions

description: ABSTRACT This study aimed to describe the functional and organizational attributes of Brazilian Poison Control Centers (PCC) inserted in the Urgency e Emergency Care Network of the Unified Health System (SUS). A descriptive study was conducted through an online questionnaire, made available on an electronic website and applied to professionals representing the PCC. Out of the 31 CIATox invited, 19 (61%) accepted and were included in the study. PCC offer full-time telephone and/or face-to-face care and 39 types of activities, with emphasis on clinical advice for health professionals. They are linked to management institutions at all three levels of government, however, they have limited resources, mainly due to inadequate or insufficient funding. PCC can contribute with its expertise to the visibility of intoxications in Brazil and to the development of health care practices of the exposed or intoxicated person, integrated and operationalized through health care networks.
DOI: 10.6084/m9.figshare.7507043.v1
title: Weaning and associated factors in children from low-income communities

description: Introduction: The average duration of breastfeeding is still insufficient and differ widely taking in account the location and specific characteristic of local people involved in these studies.Aim: This research aimed at studying factors associated to weaning among South Brazilian children living in a low-income household.Material and method: Cross-sectional study was carried out enrolling 124 mothers of 1 to 12-month-old children, who were interviewed at "Pastoral da Criança" (non-governmental organization) in Almirante Tamandaré, Paraná, Brazil. The risk of weaning considered was the dependent variable and the information collected from the questionnaires, independent variables. The method used to collect information in this study was Kaplan-Meier method and Cox regression model and Spearman's rank correlation (α = 0.05).Result: Actuarial life table presented a higher weaning conditional probability at 12 months of age, followed by first and fourth months of age. Multivariate analysis pointed out that contact with bottle feeding before the sixth month of age [HR=17.16 (2.34-125.86)] and contact with pacifier before the sixth months of age [HR=3.48 (1.90-6.38)] are risk factors associated with weaning. Among children who were not breastfed at the moment of the interview, breastfeeding duration presented a positive correlation with the ages when the children had their first contact with sugar (r s=+0.419, p=0.001) and negative correlation with the use of pacifier (r s=-0.300, p=0.017).Conclusion: Results from this study showed that the use of the feeding bottle and pacifier were related to a shorter breastfeeding time span at these communities.
DOI: 10.6084/m9.figshare.7517414
title: Dealing with the vertical border: migration strategies of Hondurans in transit through Mexico

description: Abstract This paper analyzes the strategies implemented by the Honduran migrants in transit through Mexico to deal with the checkpoints deployed by Mexican authorities and the presence of criminals dedicated to the exploitation of migrants. These vicissitudes within the territory, called ' vertical border ', lead migrants to constantly reconfigure their migratory exercise. To analyze these strategies, and how they appear, fieldwork was conducted in Saltillo, Coahuila, where semi-structured interviews were applied. In another approach, to understand the composition of the Mexican vertical border, SEGOB administrative records and data from the survey about Assault and Abuse to Migrants, were used.
DOI: 10.6084/m9.figshare.7186829
title: Performing the Hyphen

description: Abstract: The goal of this paper is to present a decolonising research methodology. The first section of this paper problematises western knowledge production, using Aníbal Quijano’s colonial matrix of power. The second section theorises how an epistemological pluralism that is critical, decolonising and performative could address western knowledge production and the colonial matrix of power. The third section discusses how this methodology has been applied to Butoh to develop Critical Butoh. The final section presents He rawe tona kakahu/ She wore a becoming dress, a Butoh performance exploring the intersection of gender and colonisation, as a practical application of this methodology.