cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.4903493
title: Circadian snoRNA. from The circadian dynamics of small nucleolar RNA in the mouse liver

description: A comma separated file listing Ensembl ids for circadian genes, circadian model parameters, and F24 values.
DOI: 10.6084/m9.figshare.4903493.v1
title: Circadian snoRNA. from The circadian dynamics of small nucleolar RNA in the mouse liver

description: A comma separated file listing Ensembl ids for circadian genes, circadian model parameters, and F24 values.
DOI: 10.6084/m9.figshare.4903439
title: S1 Dataset_Contemporary use of P2Y12 in Austria_P ONE_Tscharre_et_al.sav

description: P2Y12-I in Austria
DOI: 10.6084/m9.figshare.4903451
title: Supplementary Material for: Heart Failure with Preserved and Reduced Ejection Fraction in Hemodialysis Patients: Prevalence, Disease Prediction and Prognosis

description: <i>Background/Aims:</i> Heart failure (HF) is a main cause of mortality of hemodialysis (HD) patients. While HF with reduced ejection fraction (HFrEF) is known to only affect a minority of patients, little is known about the prevalence, associations with clinical characteristics and prognosis of HF with preserved ejection fraction (HFpEF). <i>Methods:</i>We included 105 maintenance HD patients from the Medical University of Vienna into this prospective single-center cohort study and determined the prevalence of HFpEF (per the 2013 criteria of the European Society of Cardiology) and HFrEF (EF &lt;45%), using standardized post-HD transthoracic echocardiography. We also assessed clinical, laboratory and volume status parameters (by bioimpedance spectroscopy). These parameters served to calculate prediction models for both disease entities, while clinical outcomes (frequency of cardiovascular hospitalizations and/or cardiac death) were assessed prospectively over 27±4 months of follow-up. <i>Results:</i> All but 4 patients (96%) had evidence of diastolic dysfunction. 70% of the entire cohort fulfilled HF criteria (81% HFpEF, 19% HFrEF). Age, female sex, body mass index, blood pressure and dialysis vintage were predictive of HFpEF (sensitivity 86%, specificity 63%; AUC 0.87), while age, female sex, NT pro-BNP, history of coronary artery disease and atrial fibrillation were predictive of HFrEF (sensitivity 85%, specificity 90%; AUC 0.95). Compared to patients without HF, those with HFpEF and HFrEF had a higher risk of hospitalization for cardiovascular reason and/or cardiac death (adjusted HR 4.31, 95% CI 0.46-40.03; adjusted HR 3.24, 95% CI 1.08-9.75, respectively). <i>Conclusion:</i> Diastolic dysfunction and HFpEF are highly prevalent in HD patients while HFrEF only affects a minority. Distinct patient-specific characteristics predict diagnosis of either entity with good accuracy.
DOI: 10.6084/m9.figshare.4903409
title: temp.rar

description: to be added<br>
DOI: 10.6084/m9.figshare.4903451.v1
title: Supplementary Material for: Heart Failure with Preserved and Reduced Ejection Fraction in Hemodialysis Patients: Prevalence, Disease Prediction and Prognosis

description: <i>Background/Aims:</i> Heart failure (HF) is a main cause of mortality of hemodialysis (HD) patients. While HF with reduced ejection fraction (HFrEF) is known to only affect a minority of patients, little is known about the prevalence, associations with clinical characteristics and prognosis of HF with preserved ejection fraction (HFpEF). <i>Methods:</i>We included 105 maintenance HD patients from the Medical University of Vienna into this prospective single-center cohort study and determined the prevalence of HFpEF (per the 2013 criteria of the European Society of Cardiology) and HFrEF (EF &lt;45%), using standardized post-HD transthoracic echocardiography. We also assessed clinical, laboratory and volume status parameters (by bioimpedance spectroscopy). These parameters served to calculate prediction models for both disease entities, while clinical outcomes (frequency of cardiovascular hospitalizations and/or cardiac death) were assessed prospectively over 27±4 months of follow-up. <i>Results:</i> All but 4 patients (96%) had evidence of diastolic dysfunction. 70% of the entire cohort fulfilled HF criteria (81% HFpEF, 19% HFrEF). Age, female sex, body mass index, blood pressure and dialysis vintage were predictive of HFpEF (sensitivity 86%, specificity 63%; AUC 0.87), while age, female sex, NT pro-BNP, history of coronary artery disease and atrial fibrillation were predictive of HFrEF (sensitivity 85%, specificity 90%; AUC 0.95). Compared to patients without HF, those with HFpEF and HFrEF had a higher risk of hospitalization for cardiovascular reason and/or cardiac death (adjusted HR 4.31, 95% CI 0.46-40.03; adjusted HR 3.24, 95% CI 1.08-9.75, respectively). <i>Conclusion:</i> Diastolic dysfunction and HFpEF are highly prevalent in HD patients while HFrEF only affects a minority. Distinct patient-specific characteristics predict diagnosis of either entity with good accuracy.
DOI: 10.6084/m9.figshare.4903409.v1
title: temp.rar

description: to be added<br>
DOI: 10.6084/m9.figshare.4903439.v1
title: Contemporary use of P2Y12 in Austria_P ONE_Tscharre_et_al.sav

description: P2Y12-I in Austria
DOI: 10.6084/m9.figshare.4903316
title: multisensory_emotions.mat

description: Multisensory emotions data structure MATLAB
DOI: 10.6084/m9.figshare.4903316.v1
title: multisensory_emotions.mat

description: Multisensory emotions data structure MATLAB
DOI: 10.6084/m9.figshare.4903295
title: A large-scale data-based investigation on the relationships between bad weather and taxi tipping

description: This dataset includes taxi tipping data combined with hourly weather data in NYC and the R, SAS codes to apply the cumulative logit model.
DOI: 10.6084/m9.figshare.4903439.v2
title: Contemporary use of P2Y12 in Austria_P ONE_Tscharre_et_al.sav

description: P2Y12-I in Austria
DOI: 10.6084/m9.figshare.4903439.v4
title: S1 Dataset_Contemporary use of P2Y12 in Austria_P ONE_Tscharre_et_al.sav

description: P2Y12-I in Austria
DOI: 10.6084/m9.figshare.4903439.v3
title: Contemporary use of P2Y12 in Austria_P ONE_Tscharre_et_al.sav

description: P2Y12-I in Austria
DOI: 10.6084/m9.figshare.4903295.v2
title: Relationship between real-time weather and taxi tipping behaviour: A large-scale data investigation

description: This dataset includes taxi tipping data and the SAS codes to apply non-proportional models.
DOI: 10.6084/m9.figshare.4903295.v3
title: Relationship between real-time weather and taxi tipping: A large-scale data investigation

description: This dataset includes taxi tipping data and the SAS codes to apply non-proportional models.
DOI: 10.6084/m9.figshare.4903241
title: HELCATS CORHITCAT

description: This is the HELCATS CORHITCAT. It is a catalog of COR2 CMEs with the addition of a predicted arrival of each CME to a spacecraft (and its corresponding validation by cross-checking these predictions with an ICME catalog).<br>See the description file for more info.
DOI: 10.6084/m9.figshare.4903253.v1
title: Larval phenotype is modulated by past environment in the smooth newt

description: Data and R script used in the statistical analyses of this study.
DOI: 10.6084/m9.figshare.4903295.v4
title: Relationship between real-time weather and taxi tipping: A large-scale data investigation

description: This dataset includes taxi tipping data and the SAS codes to apply the partial-proportional odds model.
DOI: 10.6084/m9.figshare.4903229
title: Escape path trajectory data

description: X.mat = x coordinates of individual fish. Each row is an individual trial, columns represent individual frames. Measured in pixels. <br>Y.mat = y coordinates of individual fish. Each row is an individual trial, columns represent individual frames. Measured in pixels.<br>Trials were filmed at 15 frames per second. There are 0.9267 pixels per mm across trials. <br><br>Trials 50, 52, 66, 69 and 63 were filtered out due to not meeting criterion as described in the paper. <br>Stimpos.mat = Position of the stimulus. (frame,[x,y],trial). <br>Stimframes.mat = Time (in frames) the stimulus enters the arena.
DOI: 10.6084/m9.figshare.4903211
title: List of FDA reports

description: Fadini GP, Bonora BM, Avogaro A. SGLT2 inhibitors and diabetic ketoacidosis. Data from the FDA Adverse Event Reporting System. Diabetologia 2017 Detailed characteristics of DKA reports where an SGLT2i was listed among suspect or concomitant drugs in the FAERS from 2014 Q1 to 2016 Q3. “ND” stands for “not determined”, meaning the given FAERS records contain no data on that specific field. The following specifications apply. Primary ID: Unique number for identifying a FAERS report. This is a concatenated key of Case Id and Case version number. Case Id: Number for identifying a FAERS case. Possible duplicate (Yes/No): some FAERS records may be duplicated because more than one SGLT2i may have been associated with the event in a given patient. Outcome: DE, death. LT, life threatening. HO, hospitalization. DS, disability. OT, other serious event.<br>
DOI: 10.6084/m9.figshare.4903295.v5
title: Relationships between real-time weather and taxi tipping for perceived service: A large-scale data-based investigation

description: This dataset includes taxi tipping data and the SAS codes to apply the non-proportional odds model.
DOI: 10.6084/m9.figshare.4903190
title: Technical aspects of osteoid osteoma ablation in children using MR-guided high intensity focussed ultrasound

description: <b>Background:</b> Osteoid osteoma (OO) is a painful bone tumour occurring in children and young adults. Magnetic resonance imaging-guided high intensity focussed ultrasound (MR-HIFU) allows non-invasive treatment without ionising radiation exposure, in contrast to the current standard of care treatment with radiofrequency ablation (RFA). This report describes technical aspects of MR-HIFU ablation in the first 8 paediatric OO patients treated in a safety and feasibility clinical trial (total enrolment of up to 12 patients). <b>Materials and methods:</b> OO lesions and adjacent periosteum were treated with MR-HIFU ablation in 5–20 sonications (sonication duration = 16–48 s, frequency = 1.2 MHz, acoustic power = 20–160 W). Detailed treatment workflow, patient positioning and coupling strategies, as well as temperature and tissue perfusion changes were summarised and correlated. <b>Results:</b> MR-HIFU ablation was feasible in all eight cases. Ultrasound standoff pads were shaped to conform to extremity contours providing acoustic coupling and aided patient positioning. The energy delivered was 10 ± 7 kJ per treatment, raising maximum temperature to 83 ± 3 °C. Post ablation contrast-enhanced MRI showed ablated volumes ranging 0.46–19.4 cm<sup>3</sup> extending further into bone (7 ± 4 mm) than into soft tissue (4 ± 6 mm, <i>p</i> = 0.01, Mann–Whitney). Treatment time ranged 30–86 min for sonication and 160 ± 40 min for anaesthesia. No serious treatment-related adverse events were observed. Complete pain relief with no medication occurred in 7/8 patients within 28 days following treatment. <b>Conclusions:</b> MR-HIFU ablation of painful OO appears technically feasible in children and it may become a non-invasive and radiation-free alternative for painful OO. Therapy success, efficiency, and applicability may be improved through specialised equipment designed more specifically for extremity bone ablation.
DOI: 10.6084/m9.figshare.4903193
title: Translational contributions to tissue-specificity in rhythmic and constitutive gene expression.

description: This fileset contains:<br>- Supplementary figures (S1-S14) and figure legends to the main manuscript.<br>- Mapping outcome summary of the deep sequencing data from kidney.<br>- Go-term results of the differential TE analysis.<br>- Rhythmicity parameters of the kidney datasets.<br>- Rhythmicity parameters of the 178 common rhythmic genes.<br>- Daily expression profiles transcriptome wide, for kidney.<br>- Daily expression profiles for the 178 common rhythmic genes, for kidney and liver.<br>
DOI: 10.6084/m9.figshare.4903211.v1
title: ESM Table 3 List of FDA reports.xls

description: Detailed characteristics of diabetic ketoacidosis (DKA) reports where a sodium glucose cotransporter inhibitor (SGLT2i) was listed among suspect or concomitant drug in the FDA Adverse Event Reporting System from 2014 Q1 to 2016 Q3.Fadini GP, Bonora BM, Avogaro A. SGLT2 inhibitors and diabetic ketoacidosis. Data from the FDA Adverse Event Reporting System. Diabetologia 2017<br><br><br>
DOI: 10.6084/m9.figshare.4903190.v1
title: Technical aspects of osteoid osteoma ablation in children using MR-guided high intensity focussed ultrasound

description: <b>Background:</b> Osteoid osteoma (OO) is a painful bone tumour occurring in children and young adults. Magnetic resonance imaging-guided high intensity focussed ultrasound (MR-HIFU) allows non-invasive treatment without ionising radiation exposure, in contrast to the current standard of care treatment with radiofrequency ablation (RFA). This report describes technical aspects of MR-HIFU ablation in the first 8 paediatric OO patients treated in a safety and feasibility clinical trial (total enrolment of up to 12 patients). <b>Materials and methods:</b> OO lesions and adjacent periosteum were treated with MR-HIFU ablation in 5–20 sonications (sonication duration = 16–48 s, frequency = 1.2 MHz, acoustic power = 20–160 W). Detailed treatment workflow, patient positioning and coupling strategies, as well as temperature and tissue perfusion changes were summarised and correlated. <b>Results:</b> MR-HIFU ablation was feasible in all eight cases. Ultrasound standoff pads were shaped to conform to extremity contours providing acoustic coupling and aided patient positioning. The energy delivered was 10 ± 7 kJ per treatment, raising maximum temperature to 83 ± 3 °C. Post ablation contrast-enhanced MRI showed ablated volumes ranging 0.46–19.4 cm<sup>3</sup> extending further into bone (7 ± 4 mm) than into soft tissue (4 ± 6 mm, <i>p</i> = 0.01, Mann–Whitney). Treatment time ranged 30–86 min for sonication and 160 ± 40 min for anaesthesia. No serious treatment-related adverse events were observed. Complete pain relief with no medication occurred in 7/8 patients within 28 days following treatment. <b>Conclusions:</b> MR-HIFU ablation of painful OO appears technically feasible in children and it may become a non-invasive and radiation-free alternative for painful OO. Therapy success, efficiency, and applicability may be improved through specialised equipment designed more specifically for extremity bone ablation.
DOI: 10.6084/m9.figshare.4903211.v3
title: List of FDA reports

description: Fadini GP, Bonora BM, Avogaro A. SGLT2 inhibitors and diabetic ketoacidosis. Data from the FDA Adverse Event Reporting System. Diabetologia 2017 Detailed characteristics of DKA reports where an SGLT2i was listed among suspect or concomitant drugs in the FAERS from 2014 Q1 to 2016 Q3. “ND” stands for “not determined”, meaning the given FAERS records contain no data on that specific field. The following specifications apply. Primary ID: Unique number for identifying a FAERS report. This is a concatenated key of Case Id and Case version number. Case Id: Number for identifying a FAERS case. Possible duplicate (Yes/No): some FAERS records may be duplicated because more than one SGLT2i may have been associated with the event in a given patient. Outcome: DE, death. LT, life threatening. HO, hospitalization. DS, disability. OT, other serious event.<br>
DOI: 10.6084/m9.figshare.4903211.v2
title: List of FDA reports.xls

description: Fadini GP, Bonora BM, Avogaro A. SGLT2 inhibitors and diabetic ketoacidosis. Data from the FDA Adverse Event Reporting System. Diabetologia 2017 Detailed characteristics of DKA reports where an SGLT2i was listed among suspect or concomitant drugs in the FAERS from 2014 Q1 to 2016 Q3. “ND” stands for “not determined”, meaning the given FAERS records contain no data on that specific field. The following specifications apply. Primary ID: Unique number for identifying a FAERS report. This is a concatenated key of Case Id and Case version number. Case Id: Number for identifying a FAERS case. Possible duplicate (Yes/No): some FAERS records may be duplicated because more than one SGLT2i may have been associated with the event in a given patient. Outcome: DE, death. LT, life threatening. HO, hospitalization. DS, disability. OT, other serious event. <br>
DOI: 10.6084/m9.figshare.4903154
title: latitudinal gradient in insect immunity

description: We studied among-population differences of two parameters reflecting constitutive immunity – phenoloxidase (PO) and lytic activity – using common garden design on three distantly related moth species represented by populations ranging from northern Finland to Georgia (Caucasus).
DOI: 10.6084/m9.figshare.4903175.v1
title: Geochemistry and Sr–Nd isotope composition of Carboniferous volcanic rocks of the Jueluotage Orogenic Belt: implications for the tectonic evolution of Eastern Tianshan, China

description: The major and trace element, and Sr–Nd isotopic compositions of the Carboniferous Qi’eshan, Wutongwozi, and Yamansu volcanic rocks from the northern and southern parts of the Jueluotage Orogenic Belt in East Tianshan, China, were analysed to understand their genesis and geodynamic implications. The early Carboniferous Qi’eshan basalts are characterized by high Al<sub>2</sub>O<sub>3</sub>, with La/Sm (1.38–1.79) and Ba/La (27.06–58.76) values higher than those of typical normal mid-ocean ridge basalt. They are relatively enriched in large ion lithophile elements (LILE) and light rare earth elements (LREE), and depleted in high field strength elements. Overall, their initial Nd–Sr isotopic compositions are ε<sub>Nd</sub>(t) = (5.6–7.0) and Isr = 0.70397–0.70429, implying the magma originated from a mantle wedge source that was metasomatized by subduction-related fluids. In contrast, the late Carboniferous Wutongwozi basalts have lower Ba/La (4.86–12.82), La/Nb (0.87–2.45), and LILE concentrations. They have the isotopic characteristics of depleted asthenosphere, relatively high and heterogeneous ε<sub>Nd</sub>(t) (9.3–9.4), and high Isr (0.70471–0.70533). Thus, the late Carboniferous Wutongwozi basalts may have been derived from the partial melting of mantle sources during asthenospheric upwelling. The early Carboniferous Yamansu acid volcanic rocks are characterized by high Mg# (46–48) and Lu/Y (~0.15), and low K<sub>2</sub>O/Na<sub>2</sub>O (0.01–0.20), similar to M-type granites. However, their ε<sub>Nd</sub>(t) (5.0–5.5) and Isr (0.70642–0.70768) values are lower than those of depleted mantle, indicating they were contaminated by lower crustal material. The magma source originated from a mantle-derived magma that was contaminated by middle Tianshan massif in a continental margin arc setting. Based on the results and previous field-based studies, we conclude that the Carboniferous volcanics in the Jueluotage Orogenic Belt formed in a complex trench–arc–basin setting in the Kuguertage–Aqikuduke Suture Zone.
DOI: 10.6084/m9.figshare.4903154.v1
title: latitudinal gradient in insect immunity

description: We studied among-population differences of two parameters reflecting constitutive immunity – phenoloxidase (PO) and lytic activity – using common garden design on three distantly related moth species represented by populations ranging from northern Finland to Georgia (Caucasus).
DOI: 10.6084/m9.figshare.4903145
title: Characterisation of data resources for <i>in silico</i> modelling: benchmark datasets for ADME properties

description: <b>Introduction</b>: The cost of <i>in vivo</i> and <i>in vitro</i> screening of ADME properties of compounds has motivated efforts to develop a range of in silico models. At the heart of the development of any computational model are the data; high quality data are essential for developing robust and accurate models. The characteristics of a dataset, such as its availability, size, format and type of chemical identifiers used, influence the modelability of the data. <b>Areas covered</b>: This review explores the usefulness of publicly available ADME datasets for researchers to use in the development of predictive models. More than 140 ADME datasets were collated from publicly available resources and the modelability of 31 selected datasets were assessed using specific criteria derived in this study. <b>Expert opinion</b>: Publicly available datasets differ significantly in information content and presentation. From a modelling perspective, datasets should be of adequate size, available in a user-friendly format with all chemical structures associated with one or more chemical identifiers suitable for automated processing (e.g. CAS number, SMILES string or InChIKey). Recommendations for assessing dataset suitability for modelling and publishing data in an appropriate format are discussed.
DOI: 10.6084/m9.figshare.4903124
title: Multivariate skeletal analyses support a taxonomic distinction between New Zealand and Australian <i>Eudyptula</i> penguins (Sphenisciformes: Spheniscidae)

description: Recent genetic analyses have revealed evidence for the existence of two distinct lineages of Little Penguin (genus <i>Eudyptula</i>), one endemic to New Zealand (<i>E. minor</i>), and the other widespread along the coasts of Australia and south-east New Zealand (<i>E. novaehollandiae</i>). Here we present the first comprehensive morphometric analysis of complete <i>Eudyptula</i> skeletons. We show that variability in <i>Eudyptula</i> body and bill size is associated with sea surface temperature gradients, suggesting that thermoregulatory processes underpin morphological variation in these seabirds. More importantly, we detect osteological differentiation between New Zealand and Australian specimens, providing further support for the taxonomic separation of these behaviourally and genetically distinct lineages. Broadly, our study shows the value of multivariate osteological analyses in helping to resolve the status of genetic lineages that appear morphologically ‘cryptic’ when considering external morphometrics and plumage features alone.
DOI: 10.6084/m9.figshare.4903124.v1
title: Multivariate skeletal analyses support a taxonomic distinction between New Zealand and Australian <i>Eudyptula</i> penguins (Sphenisciformes: Spheniscidae)

description: Recent genetic analyses have revealed evidence for the existence of two distinct lineages of Little Penguin (genus <i>Eudyptula</i>), one endemic to New Zealand (<i>E. minor</i>), and the other widespread along the coasts of Australia and south-east New Zealand (<i>E. novaehollandiae</i>). Here we present the first comprehensive morphometric analysis of complete <i>Eudyptula</i> skeletons. We show that variability in <i>Eudyptula</i> body and bill size is associated with sea surface temperature gradients, suggesting that thermoregulatory processes underpin morphological variation in these seabirds. More importantly, we detect osteological differentiation between New Zealand and Australian specimens, providing further support for the taxonomic separation of these behaviourally and genetically distinct lineages. Broadly, our study shows the value of multivariate osteological analyses in helping to resolve the status of genetic lineages that appear morphologically ‘cryptic’ when considering external morphometrics and plumage features alone.