cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.14282243
title: Changrui enema inhibits inflammation-induced angiogenesis in acute radiation proctitis by regulating NF-κB and VEGF

description: Abstract Purpose Changrui enema, a traditional Chinese medicine prescription, is used as a supplementary treatment for acute radiation proctitis (ARP). Herein we explored the inhibition effects of Changrui enema on NF-κB and VEGF in ARP mice. Methods A total of 120 C57BL/6 mice were divided randomly into normal mice group, ARP mice group, western medicine enema group (dexamethasone combined with gentamicin), and Changrui enema group. ARP mice were established by pelvic local irradiation. The expression of IL-1β, NF-κB, VEGF, AQP1, AQP3, p-ERK1/2 and p-JNK was determined by immunohistochemistry or western blot. Results The study firstly found that Changrui enema alleviated ARP mice. The expression of IL-1β, NF-κB, VEGF, AQP1 and p-ERK1/2 was increased in ARP mice, and was reserved by Changrui enema. However, the expression of AQP3 and p-JNK was decreased in ARP mice, and was up-regulated by Changrui enema. Conclusions Changrui enema is an effective treatment with fewer side effects for ARP. The mechanism of Changrui enema may be related to the inhibition of inflammation-induced angiogenesis. Changrui enema inhibits IL-1β and NF-κB expression as well as VEGF expression. Interestingly, AQP1 promotes angiogenesis, while AQP3 inhibits inflammation. Changrui enema probably inhibits AQP1 expression by down-regulating p-ERK1/2, and improves AQP3 expression by up-regulating p-JNK.
DOI: 10.6084/m9.figshare.14282321.v1
title: A modified rabbit model of tracheal stenosis and a household endoscope. More simplicity and accessibility

description: Abstract Purpose: To develop a simpler animal model for benign tracheal stenosis and introduce a low-cost household endoscope for postmodeling endotracheal evaluation. Methods: Twenty rabbits were randomly divided into a model group (15 rabbits, subjected to transoral nylon brush scraping of the trachea) and a mock group (5 rabbits, merely exempted from scraping), a household endoscope was then introduced for weekly endoscopic examination. Meanwhile, other 15 rabbits (modeling like the model group) underwent batch tracheal resection at different postintervention times for pathological analysis. Results: The model group presented a low mortality and few complications. The endoscope could obtain adequate images for stenosis assessment, which showed that the models presented homogeneous injury after scraping and developed a mature scar stricture at 28 days postoperatively with a mean stenosis degree of 65.9%, and 71.4% (10/14) above Myer–Cotton’s grade II. The pathological findings were consistent with the clinicopathological process of human. No stenosis was found in mock group. Conclusion: The modified model is simpler, minimally invasive and reliable, while the household endoscope is competent for model’s follow-up, providing easily accessible and useful tools for facilitating more extensive studies of benign tracheal stenosis.
DOI: 10.6084/m9.figshare.14282236
title: A practical new strategy to prevent bile duct injury during laparoscopic cholecystectomy. A single-center experience with 5539 cases

description: Abstract Purpose Bile duct injury (BDI) is a catastrophic complication of cholecystectomy, and misidentification of the cystic anatomy is considered to be the main cause. Although several techniques have been developed to prevent BDI, such as the “critical view of safety”, the infundibular technique, the rates remain higher during laparoscopic cholecystectomy (LC) than during open surgery. We, here, propose a practical new strategy for ductal identification, that can help to prevent laparoscopic bile duct injury. Methods A retrospective study of 5539 patients who underwent LC from March 2007 to February 2019 at a single institution was conducted. The gallbladder infundibulum was classified by its position located on an imaginary clock with the gallbladder neck as the center point of the dial, 3-o’clock position as cranial, 6-o’clock as dorsal, 9-o’clock as caudal, and 12-o’clock as ventral, as well as the axial position. Patient demographics, pathologic variables and infundibulum classification were evaluated. Detailed analysis of ductal identification based on gallbladder infundibulum position was performed in this study. All infundibulum positions were recorded by intraoperative laparoscopic video or photographic images. Results All the patients successfully underwent LC during the study period. No conversion or serious complications such as biliary injury occurred. Gallbladders with infundibulum of 3-o’clock position, 6-o’clock position, 9-o’clock position, 12-o’clock position, axial position were 12.3%, 23.4%, 28.0%, 4.2%, and 32.1%, respectively. The 3-o’clock and 12-o’clock position were pitfalls that might cause biliary injury. Conclusion The gallbladder infundibulum as a navigator is useful for ductal identification to reduce BDI and improve the safety of LC.
DOI: 10.6084/m9.figshare.14282366
title: Inhibition of CXCR2 alleviates the development of abdominal aortic aneurysm in Apo E-/- mice

description: ABSTRACT Purpose To investigate the relationship between atherosclerotic abdominal aortic aneurysm (AAA) and CXC chemokine receptor type 2 (CXCR2). Methods Mouse AAA model was established by embedding angiotensin-II pump (1000 ng/kg/min) in ApoE-/- mice. Mice were received SB225002, a selective CXCR2 antagonist, for treatment. Blood pressure was recorded, and CXCR2+ macrophages were examined by flow cytometry analysis. Terminal-deoxynucleotidyl transferase mediated nick end labeling (TUNEL) staining was performed to detect cell apoptosis of abdominal aortic aneurysms. Macrophages were isolated from ApoE-/- mice and treated with Ang II and/or SB225002. Dihydroethidium staining was carried out to determine reactive oxygen species (ROS) activity. Enzyme-linked immunosorbent assay (ELISA) was performed to determine the production of IL-1β and TNF-α. The corresponding gene expressions were measured using real-time polymerase chain reaction (PCR), western blot, and immunohistochemistry staining. Results We found that Ang II activated the expression of CXCR2 in monocytes during the formation of AAA. Inhibition of CXCR2 significantly reduced the size of AAA, attenuated inflammation and phenotypic changes in blood vessels. Ang II-induced macrophages exhibited elevated ROS activity, and elevated levels of 1β and TNF-α, which were then partly abolished by SB225002. Conclusions CXCR2 plays an important role in AAA, suggesting that inhibiting CXCR2 may be a new treatment for AAA.
DOI: 10.6084/m9.figshare.13225687.v1
title: Additional file 3 of Complete genome analysis of a virulent Vibrio scophthalmi strain VSc190401 isolated from diseased marine fish half-smooth tongue sole, Cynoglossus semilaevis

description: Additional file 3: Table S1. The COG functional annotation information.
DOI: 10.6084/m9.figshare.13225693.v1
title: Additional file 5 of Complete genome analysis of a virulent Vibrio scophthalmi strain VSc190401 isolated from diseased marine fish half-smooth tongue sole, Cynoglossus semilaevis

description: Additional file 5: Table S3. The KEGG pathway annotation information.
DOI: 10.7270/q24t6mcs
title: BindingDB Entry 50048251: Design and Synthesis of Novel, Selective GPR40 AgoPAMs.

description: Small molecule binding data for protein Free fatty acid receptor 1, Uniprot O14842
DOI: 10.7270/q25h7j5v
title: BindingDB Entry 50047708: Potent anticholinesterasic and neuroprotective pyranotacrines as inhibitors of beta-amyloid aggregation, oxidative stress and tau-phosphorylation for Alzheimer's disease.

description: Small molecule binding data for protein Acetylcholinesterase, Uniprot O42275
DOI: 10.7270/q29888xm
title: BindingDB Entry 50047707: Discovery of pyrido[3,4-g]quinazoline derivatives as CMGC family protein kinase inhibitors: Design, synthesis, inhibitory potency and X-ray co-crystal structure.

description: Small molecule binding data for protein Cyclin-Dependent Kinase 5 (CDK5), Dual specificty protein kinase CLK1, and Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A, Uniprot P49759, Q00535, Q15078, and Q63470
DOI: 10.7270/q2db83v8
title: BindingDB Entry 50048249: Structure-Guided Design of Novel, Potent, and Selective Macrocyclic Plasma Kallikrein Inhibitors.

description: Small molecule binding data for protein Coagulation factor X and plasma kallikrein, Coagulation factor X/antithrombin III, Coagulation factor XI, Coagulation factor XII, Plasminogen, Prothrombin, and Tissue-type plasminogen activator, Uniprot P00734, P00742, P00747, P00748, P00750, P03951, and P03952
DOI: 10.7270/q2h41tdb
title: BindingDB Entry 50048256: Synthesis and biological evaluation of novel hybrids of highly potent and selectivea4ß2-Nicotinic acetylcholine receptor (nAChR) partial agonists.

description: Small molecule binding data for protein Acetylcholine receptor protein alpha chain/beta chain/delta chain /gamma chain, Neuronal acetylcholine receptor protein alpha-2/beta-4 subunit, Neuronal acetylcholine receptor protein alpha-3/beta-4 subunit, Neuronal acetylcholine receptor protein alpha-4/beta-2 subunit, and Neuronal acetylcholine receptor protein alpha-4/beta-4 subunit, Uniprot P02708, P04757, P07510, P09483, P11230, P12389, P12390, P12392, P17787, P43681, and Q07001
DOI: 10.7270/q2ms3vsx
title: BindingDB Entry 50048255: Synthesis and biological evaluation of new aryl-alkyl(alkenyl)-4-benzylpiperidines, novel Sigma Receptor (SR) modulators, as potential anticancer-agents.

description: Small molecule binding data for protein OPIATE Sigma, Sigma, and Sigma-1 receptor, Uniprot Q60492, Q99720, and Q9R0C9
DOI: 10.7270/q2nk3h0q
title: BindingDB Entry 50047712: Discovery of Brigatinib (AP26113), a Phosphine Oxide-Containing, Potent, Orally Active Inhibitor of Anaplastic Lymphoma Kinase.

description: Small molecule binding data for protein ALK tyrosine kinase receptor, Insulin receptor, Insulin-like growth factor I receptor, Proto-oncogene tyrosine-protein kinase ROS, Tyrosine-protein kinase receptor FLT3, and VEGF-receptor 2 and tyrosine-protein kinase SRC, Uniprot P06213, P08069, P08922, P12931, P36888, and Q9UM73
DOI: 10.7270/q2rj4mg6
title: BindingDB Entry 50048254: Repurposing N,N'-bis-(arylamidino)-1,4-piperazinedicarboxamidines: An unexpected class of potent inhibitors of cholinesterases.

description: Small molecule binding data for protein Acetylcholinesterase and Cholinesterase, Uniprot O42275 and P81908
DOI: 10.7270/q2sb47q1
title: BindingDB Entry 50047711: Urotensin II((4-11)) Azasulfuryl Peptides: Synthesis and Biological Activity.

description: Small molecule binding data for protein UTS2R and Urotensin II receptor, Uniprot P49684 and Q9UKP6
DOI: 10.7270/q2w95c5g
title: BindingDB Entry 50048253: Design and Synthesis of Janus Kinase 2 (JAK2) and Histone Deacetlyase (HDAC) Bispecific Inhibitors Based on Pacritinib and Evidence of Dual Pathway Inhibition in Hematological Cell Lines.

description: Small molecule binding data for protein Histone deacetylase, Histone deacetylase 1/2/3/6, Histone deacetylase 1/8, Histone deacetylase 11, Histone deacetylase 2/Nuclear receptor corepressor 2, Histone deacetylase 3/Nuclear receptor corepressor 2, JAK2/JAK1, JAK2/TYK2, JAK3/JAK1, and Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform, Uniprot A0A024QZ26, O15379, O60674, P29597, P48736, P52333, Q13547, Q92769, Q969S8, Q96DB2, Q9BY41, Q9UBN7, and Q9Y618
DOI: 10.7270/q2x350d9
title: BindingDB Entry 50047710: Synthesis of new thiazolo-celecoxib analogues as dual cyclooxygenase-2/15-lipoxygenase inhibitors: Determination of regio-specific different pyrazole cyclization by 2D NMR.

description: Small molecule binding data for protein Prostaglandin G/H synthase (Cyclooxygenase-2) and Prostaglandin G/H synthase (cyclooxygenase), Uniprot P05979 and P79208
DOI: 10.7270/q2028th0
title: BindingDB Entry 50048260: Design, synthesis and evaluation of novel 2-amino-3-(naphth-2-yl)propanoic acid derivatives as potent inhibitors of platelet aggregation.

description: Small molecule binding data for protein Integrin alpha-IIb/beta-3, Uniprot P05106 and P08514
DOI: 10.7270/q20v8fq2
title: BindingDB Entry 50047717: New Atglistatin closely related analogues: Synthesis and structure-activity relationship towards adipose triglyceride lipase inhibition.

description: Small molecule binding data for protein Patatin-like phospholipase domain-containing protein 2, Uniprot O60643 Q5EFF5 Q9NQ62 Q6XYE5 Q96ET6 Q96AD5 Q9NQ61
DOI: 10.7270/q23t9k6z
title: BindingDB Entry 50048259: Structure-activity relationship (SAR) study and design strategies of nitrogen-containing heterocyclic moieties for their anticancer activities.

description: Small molecule binding data for protein Phosphodiesterase 3, Uniprot Q14432
DOI: 10.7270/q27m09xt
title: BindingDB Entry 50048258: Synthesis and biological evaluation of a series of N-alkylated imidazole alkanoic acids as mGAT3 selective GABA uptake inhibitors.

description: Small molecule binding data for protein Betaine transporter, GABA transporter, GABA transporter 1, and GABA transporter 3, Uniprot P23978, P30531, P31646, P31649, P31650, P31651, P48065, and P48066
DOI: 10.7270/q28917ss
title: BindingDB Entry 50047715: Effects of N-Substitutions on the Tetrahydroquinoline (THQ) Core of Mixed-Efficacyµ-Opioid Receptor (MOR)/d-Opioid Receptor (DOR) Ligands.

description: Small molecule binding data for protein Kappa-type opioid receptor, Nociceptin/mu opioid receptor, and Opioid receptors; mu & delta, Uniprot P33533, P33535, and P41145
DOI: 10.7270/q2cc12p0
title: BindingDB Entry 50048257: Further investigation of inhibitors of MRSA pyruvate kinase: Towards the conception of novel antimicrobial agents.

description: Small molecule binding data for protein Pyruvate kinase, Uniprot Q6GG09
DOI: 10.7270/q2d220jz
title: BindingDB Entry 50047714: 2-(3-Methoxyphenyl)quinazoline Derivatives: A New Class of Direct Constitutive Androstane Receptor (CAR) Agonists.

description: Small molecule binding data for protein Aryl hydrocarbon receptor, Cytochrome P450 1A, Cytochrome P450 2B6, Cytochrome P450 2C9, Cytochrome P450 2D6 (2D6), Cytochrome P450 3A, Nuclear receptor subfamily 1 group I member 3, Pregnane X receptor (PXR), and Vitamin D receptor, Uniprot O75469, P05177, P08684, P10635, P11473, P11712, P20813, P35869, and Q14994
DOI: 10.7270/q2ht2r80
title: BindingDB Entry 50047713: PEGylated Bis-Sulfonamide Carbonic Anhydrase Inhibitors Can Efficiently Control the Growth of Several Carbonic Anhydrase IX-Expressing Carcinomas.

description: Small molecule binding data for protein Carbonic Anhydrase XIV, Carbonic anhydrase, Carbonic anhydrase 12, Carbonic anhydrase 2, Carbonic anhydrase 4, and Carbonic anhydrase 9, Uniprot O43570, P00915, P00918, P22748, Q16790, and Q9ULX7
DOI: 10.7270/q2qj7k9c
title: BindingDB Entry 50048262: Design and discovery of 4-anilinoquinazoline-urea derivatives as dual TK inhibitors of EGFR and VEGFR-2.

description: Small molecule binding data for protein Epidermal growth factor receptor and Vascular endothelial growth factor receptor 2, Uniprot P00533 and P35968
DOI: 10.7270/q24j0h2g
title: BindingDB Entry 50047716: Discovery of a novel 6,7-disubstituted-4-(2-fluorophenoxy)quinolines bearing 1,2,3-triazole-4-carboxamide moiety as potent c-Met kinase inhibitors.

description: Small molecule binding data for protein Epidermal growth factor receptor, Hepatocyte growth factor receptor, Macrophage-stimulating protein receptor, Tyrosine-protein kinase Kit (Kit), Tyrosine-protein kinase receptor FLT3, and Vascular endothelial growth factor receptor 2, Uniprot P00533, P08581, P10721, P35968, P36888, and Q04912
DOI: 10.7270/q2kw5j1t
title: BindingDB Entry 50048263: Synthesis and evaluation of C9 alkoxy analogues of (-)-stepholidine as dopamine receptor ligands.

description: Small molecule binding data for protein Dopamine D1 and D2 receptor, Dopamine receptor, and Dopamine receptor D2L/neurotensin receptor NTS1, Uniprot P14416, P21728, and P35462
DOI: 10.7270/q2rb76j6
title: BindingDB Entry 50047719: Further optimization of the M1 PAM VU0453595: Discovery of novel heterobicyclic core motifs with improved CNS penetration.

description: Small molecule binding data for protein Muscarinic acetylcholine receptor M1, Uniprot P08482 and P11229
DOI: 10.7270/q2v98b2j
title: BindingDB Entry 50048261: Targeting cytochrome P450 (CYP) 1B1 with steroid derivatives.

description: Small molecule binding data for protein Cytochrome P450 1B1, Uniprot Q16678
DOI: 10.7270/q2w37z8j
title: BindingDB Entry 50047718: On the vasoprotective mechanisms underlying novelß-phosphorylated nitrones: Focus on free radical characterization, scavenging and NO-donation in a biological model of oxidative stress.

description: Small molecule binding data for protein Xanthine oxidase, Uniprot P47989
DOI: 10.7270/q23n259z
title: BindingDB Entry 50047724: Identification of novel EZH2 inhibitors through pharmacophore-based virtual screening and biological assays.

description: Small molecule binding data for protein Histone-lysine N-methyltransferase EZH2, Uniprot Q15910
DOI: 10.7270/q27946mz
title: BindingDB Entry 50047723: Synthesis and bioactivity of pyrazole and triazole derivatives as potential PDE4 inhibitors.

description: Small molecule binding data for protein cAMP-specific 3',5'-cyclic phosphodiesterase 4B, Uniprot Q07343
DOI: 10.7270/q2c24zb9
title: BindingDB Entry 50047722: Novel substituted isoxazole FXR agonists with cyclopropyl, hydroxycyclobutyl and hydroxyazetidinyl linkers: Understanding and improving key determinants of pharmacological properties.

description: Small molecule binding data for protein Bile acid receptor FXR, Uniprot Q96RI1
DOI: 10.7270/q2g44s9d
title: BindingDB Entry 50048264: New azepino[4,3-b]indole derivatives as nanomolar selective inhibitors of human butyrylcholinesterase showing protective effects against NMDA-induced neurotoxicity.

description: Small molecule binding data for protein Acetylcholinesterase and Cholinesterase, Uniprot O42275, P06276, P22303, and P81908
DOI: 10.7270/q2gt5q35
title: BindingDB Entry 50047721: Novel c-Met inhibitory olive secoiridoid semisynthetic analogs for the control of invasive breast cancer.

description: Small molecule binding data for protein Hepatocyte growth factor receptor, Uniprot P08581
DOI: 10.7270/q2mk6ftg
title: BindingDB Entry 50047720: Toward the Validation of Maternal Embryonic Leucine Zipper Kinase: Discovery, Optimization of Highly Potent and Selective Inhibitors, and Preliminary Biology Insight.

description: Small molecule binding data for protein Maternal embryonic leucine zipper kinase, Mitogen-activated protein kinase kinase kinase kinase 4, Platelet-derived growth factor receptor, Serine/threonine-protein kinase haspin, Tyrosine-protein kinase Kit (Kit), and Tyrosine-protein kinase receptor FLT3, Uniprot O95819, P10721, P16234, P36888, Q14680, and Q8TF76
DOI: 10.25989/1c2r-8b60
title: Materials Experiment and Analysis Database:
DOI: 10.25989/55sx-fy10
title: Materials Experiment and Analysis Database:
DOI: 10.25989/fbpv-r126
title: Materials Experiment and Analysis Database:
DOI: 10.25989/p9we-kh56
title: Materials Experiment and Analysis Database:
DOI: 10.25989/scsg-p461
title: Materials Experiment and Analysis Database:
DOI: 10.25989/vrqa-1033
title: Materials Experiment and Analysis Database:
DOI: 10.7270/q2ft8nzc
title: BindingDB Entry 50047729: Coumarin sulfonamides derivatives as potent and selective COX-2 inhibitors with efficacy in suppressing cancer proliferation and metastasis.

description: Small molecule binding data for protein Cyclooxygenase and Cyclooxygenase-1 (COX-1), Uniprot P23219 and P35354
DOI: 10.7270/q2kk9dqj
title: BindingDB Entry 50047728: Synthesis and evaluation of a series of 4-azaindole-containing p21-activated kinase-1 inhibitors.

description: Small molecule binding data for protein PAK1 and Serine/threonine-protein kinase PAK 4, Uniprot O96013 and Q13153
DOI: 10.7270/q2qc05ft
title: BindingDB Entry 50047727: Discovery of N-(3-fluoro-4-methylsulfonamidomethylphenyl)urea as a potent TRPV1 antagonistic template.

description: Small molecule binding data for protein Transient receptor potential cation channel subfamily V member 1, Uniprot Q8NER1
DOI: 10.7270/q2v40x4q
title: BindingDB Entry 50047726: Enriching screening libraries with bioactive fragment space.

description: Small molecule binding data for protein Casein Kinase II, Uniprot P68400
DOI: 10.7270/q2zw1nvq
title: BindingDB Entry 50047725: [Dmt(1)]DALDA analogues modified with tyrosine analogues at position 1.

description: Small molecule binding data for protein Nociceptin/mu opioid receptor, Opioid receptors; mu & delta, Opioid receptors; mu and delta, and mu/kappa opioid receptor, Uniprot P32300, P33533, P33535, P41144, and P97266
DOI: 10.25989/1jcc-eg02
title: Materials Experiment and Analysis Database:
DOI: 10.25989/3pjb-w878
title: Materials Experiment and Analysis Database:
DOI: 10.25989/e3x8-tm73
title: Materials Experiment and Analysis Database:
DOI: 10.25989/sxac-ag30
title: Materials Experiment and Analysis Database:
DOI: 10.25989/t0cf-b811
title: Materials Experiment and Analysis Database:
DOI: 10.25989/yd0j-6529
title: Materials Experiment and Analysis Database:
DOI: 10.25989/yf85-8y33
title: Materials Experiment and Analysis Database:
DOI: 10.7270/q22n547g
title: BindingDB Entry 50047732: A cascade screening approach for the identification of Bcr-Abl myristate pocket binders active against wild type and T315I mutant.

description: Small molecule binding data for protein Tyrosine-protein kinase ABL1, Uniprot P00519
DOI: 10.7270/q26d5vxz
title: BindingDB Entry 50047731: Development of novel 1,4-benzodiazepine-based Michael acceptors as antitrypanosomal agents.

description: Small molecule binding data for protein Rhodesain
DOI: 10.7270/q2b27x7c
title: BindingDB Entry 50047730: New structure-activity relationships of N-acetamide substituted pyrazolopyrimidines as pharmacological ligands of TSPO.

description: Small molecule binding data for protein Peripheral-Type Benzodiazepine Receptor, Uniprot P16257
DOI: 10.7270/q2pc349f
title: BindingDB Entry 50047735: Binding mode prediction of aplysiatoxin, a potent agonist of protein kinase C, through molecular simulation and structure-activity study on simplified analogs of the receptor-recognition domain.

description: Small molecule binding data for protein Protein kinase C delta, Uniprot P28867
DOI: 10.7270/q2t43w1s
title: BindingDB Entry 50047734: Synthesis, antiproliferative and pro-apoptotic activity of 2-phenylindoles.

description: Small molecule binding data for protein Estradiol receptor alpha (ERα) and Estradiol receptor beta (ERβ), Uniprot P03372 and Q92731
DOI: 10.7270/q2xw4mrs
title: BindingDB Entry 50047733: Design and synthesis of 1H-pyrazolo[3,4-c]pyridine derivatives as a novel structural class of potent GPR119 agonists.

description: Small molecule binding data for protein G-protein coupled receptor 119 (GPR119), Uniprot Q8TDV5
DOI: 10.7270/q21n832n
title: BindingDB Entry 50047740: Binding characterization, synthesis and biological evaluation of RXRa antagonists targeting the coactivator binding site.

description: Small molecule binding data for protein Retinoic acid receptor alpha/Retinoid X receptor alpha, Uniprot P19793
DOI: 10.7270/q25d8tsk
title: BindingDB Entry 50047739: Synthesis and in vitro reactivation study of isonicotinamide derivatives of 2-(hydroxyimino)-N-(pyridin-3-yl)acetamide as reactivators of Sarin and VX inhibited human acetylcholinesterase (hAChE).

description: Small molecule binding data for protein Acetylcholinesterase, Uniprot P22303
DOI: 10.7270/q2959kgv
title: BindingDB Entry 50047738: Steric structure-activity relationship of cyproheptadine derivatives as inhibitors of histone methyltransferase Set7/9.

description: Small molecule binding data for protein SET domain-containing protein 7/9 (Set7/9) and Serotonin (5-HT) receptor, Uniprot P14842 and Q8WTS6