cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.27936017
title: Systems biology and molecular modeling assisted exploration of the underlying mechanism of Safflower (<i>Carthamus tinctorius L.</i>) in the treatment of hearing loss

description: Hearing loss is the incapability to hear sound, either partially or fully. One potential natural remedy for hearing loss is the use of <i>Carthamus tinctorius</i>, commonly known as safflower, contains bioactive compounds, including flavonoids, phenolic acids, and terpenoids, which possess potent antioxidant and anti-inflammatory activities. This study uses network pharmacology to identify the potential therapeutic effects of these compounds on hearing loss. We identified 17 active compounds of <i>C. tinctorius</i> with favorable ADME properties through a litrature search. Potential targets for these compounds were found using databases like STITCH and Swiss Target Prediction, as well as the GeneCards database to retrieve hearing loss-related potential targets. A Venn diagram was drawn to determine shared targets, and GO enrichment and KEGG pathways analysis of 64 key targets were conducted DAVID database. Protein-protein interactions (PPIs) were analyzed via STRING database, and a compound-target-pathway network was created in Cytoscape. Molecular docking studies focused on one hub gene, namely, tumor necrosis factor (TNF) revealing that <i>C. tinctorius</i>’s compounds have high affinity for TNF, suggesting a potential therapeutic link to hearing loss. Finally, molecular dynamics simulations and calculations of binding free energy showed TNF_Beta Sitosterol and TNF_Campesterol were more stable than TNF_Cholesterol. Our findings indicate that <i>C. tinctorius</i> may have therapeutic potential for hearing loss by targeting key genes and pathways. However, further <i>in-vivo</i> and <i>in-vitro</i> studies are needed to confirm these findings and determine optimal treatment parameters.
DOI: 10.6084/m9.figshare.29313601.v1
title: Synthesis, structure, DNA docking, pharmacokinetics/ADMET, Hirshfeld surface analysis, and antimicrobial studies on biphenyl appended pyrrolidine complexes

description: Biphenyl anchored pyrrolidine complexes [MLCl<sub>2</sub>], [where M = Co (<b>1</b>), Ni (<b>2</b>), Cu (<b>3</b>) and Zn (<b>4</b>); <b><i>L</i> </b>=<b> </b>6-(2-(pyrrolidin-1-yl)ethyl)-6,7-dihydro-5H-dibenzo[c,e]azepine] were synthesized and characterized by elemental analysis, UV-Vis, FT-IR, ESI-MS, and NMR (in case of <b>4</b>). Single crystal XRD revealed that all the complexes adopt distorted tetrahedral geometry. DFT calculations with their relative energies were compared with XRD structure. Absorption, oscillator strength, excitation energy, molecular orbital contributions were obtained from TDDFT calculation. The computed UV-Vis absorption data is comparable with experimental UV-Vis data. Molecular docking studies verified that all complexes strongly bind with DNA (PDB ID: 1BNA) through major groove interactions. The ligand and the complexes exhibit an elevated permeability of the blood-brain barrier and GI absorption, according to the SwissADME prediction criteria. The values of skin permeability (logKp) for the ligand and complexes <b>1-4</b> were determined to be −5.61, −5.27, −5.27, −5.30, and −5.31 cms<sup>−1</sup>, respectively. All the complexes and the ligand were projected to function as a biological barrier, a transporter, and a substrate of P-glycoprotein (P-gp), which is responsible for the ADME of medications. Using Hirshfeld surface investigation, the intermolecular interactions within the crystal network were identified to support the prominent contribution from H∙∙∙∙∙H interactions, followed by Cl∙∙∙∙∙H and C∙∙∙∙∙H interactions, respectively. In the preliminary investigations, all the complexes displayed significant antibacterial properties against both Gram-positive and Gram-negative bacterial strains such as Staphylococcus aureus and Escherichia coli, respectively; those were obtained from human clinical isolates. Notably, the copper(II) complex, <b>3</b> showed better antibacterial activity in comparison to other complexes. Biphenyl appended pyrrolidine complexes [MLCl<sub>2</sub>] were symthesized.The geometry and interaction energy were assessed via DFT and Hirschfeld surface analysis.Docking analyses verified the binding of all complexes with DNA.To predict pharmacokinetic properties, an in silico ADMET study was conducted.Copper complex showed better antibacterial activity. Biphenyl appended pyrrolidine complexes [MLCl<sub>2</sub>] were symthesized. The geometry and interaction energy were assessed via DFT and Hirschfeld surface analysis. Docking analyses verified the binding of all complexes with DNA. To predict pharmacokinetic properties, an in silico ADMET study was conducted. Copper complex showed better antibacterial activity.
DOI: 10.6084/m9.figshare.27936017.v1
title: Systems biology and molecular modeling assisted exploration of the underlying mechanism of Safflower (<i>Carthamus tinctorius L.</i>) in the treatment of hearing loss

description: Hearing loss is the incapability to hear sound, either partially or fully. One potential natural remedy for hearing loss is the use of <i>Carthamus tinctorius</i>, commonly known as safflower, contains bioactive compounds, including flavonoids, phenolic acids, and terpenoids, which possess potent antioxidant and anti-inflammatory activities. This study uses network pharmacology to identify the potential therapeutic effects of these compounds on hearing loss. We identified 17 active compounds of <i>C. tinctorius</i> with favorable ADME properties through a litrature search. Potential targets for these compounds were found using databases like STITCH and Swiss Target Prediction, as well as the GeneCards database to retrieve hearing loss-related potential targets. A Venn diagram was drawn to determine shared targets, and GO enrichment and KEGG pathways analysis of 64 key targets were conducted DAVID database. Protein-protein interactions (PPIs) were analyzed via STRING database, and a compound-target-pathway network was created in Cytoscape. Molecular docking studies focused on one hub gene, namely, tumor necrosis factor (TNF) revealing that <i>C. tinctorius</i>’s compounds have high affinity for TNF, suggesting a potential therapeutic link to hearing loss. Finally, molecular dynamics simulations and calculations of binding free energy showed TNF_Beta Sitosterol and TNF_Campesterol were more stable than TNF_Cholesterol. Our findings indicate that <i>C. tinctorius</i> may have therapeutic potential for hearing loss by targeting key genes and pathways. However, further <i>in-vivo</i> and <i>in-vitro</i> studies are needed to confirm these findings and determine optimal treatment parameters.
DOI: 10.60600/yu/axn2rp
title: America’s Congress: Actions in the Public Sphere, James Madison Through Newt Gingrich

description: Dataset and materials for David R. Mayhew, America’s Congress: Actions in the Public Sphere, James Madison Through Newt Gingrich (New Haven, CT: Yale University Press, 2000)
DOI: 10.15468/dl.ka6snn
title: Occurrence Download

description: A dataset containing 529 species occurrences available in GBIF matching the query:
{
 "and" : [
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "TaxonKey is Iheringichthys labrosus"
 ]
}

 The dataset includes 529 records from 23 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0000090-260129131611470/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.60600/yu/ftg1yd
title: Divided We Govern

description: Dataset and materials, current through 2025, for David R. Mayhew, Divided We Govern: Party Control, Lawmaking, and Investigations, 1946-2002.
DOI: 10.60600/yu/4e8ygb
title: Intensity, Geography, and Time: Three Controversies Indexed by Major Repeal Drives

description: Data from "Intensity, Geography, and Time: Three Controversies Indexed by Major Repeal Drives" in Studies in American Political Development 39, no. 2 (October 2025): 183–201
DOI: 10.60600/yu/f15e0z
title: Incumbency Advantage in Presidential Elections

description: Replication data for David R. Mayhew, “Incumbency Advantage in Presidential Elections: The Historical Record,” Political Science Quarterly 123:2 (Summer 2008), 201-228
DOI: 10.25824/redu/sm7ngw
title: Monophasic salmonella in Brazil

description: Dados relacionados ao capítulo 1 da tese de Doutorado "INVESTIGANDO PROCESSOS EVOLUTIVOS DOS GENOMAS DE Salmonella spp. A FIM DE GUIAR FUTURAS POLÍTICAS PÚBLICAS DA SAÚDE"
DOI: 10.5281/zenodo.18416078
title: Tectono-climatic driven river avulsion and societal changes in the Late Holocene Central Ganga Basin

description: The following dataset contains XRF, Grain size, Total Organic Carbon and stable carbon isotope data along with age.
DOI: 10.60600/yu/xkno4j
title: Electoral Realignments

description: Replication data for David R. Mayhew, Electoral Realignments: A Critique of an American Genre (New Haven, CT: Yale University Press, 2002)
DOI: 10.18150/karn8d
title: Formation of extremely low-volatility products from the aqueous oxidation of terpenoic acids derived from α pinene and δ-3-carene by OH chemistry

description: Stałe szybkości reakcji bimolekularnej dla wodnego utleniania pięciu kwasów terpenowych (TA) przez rodnik hydroksylowy (OH) zmierzono w ich formach obojętnych i zdeprotonowanych w zakresie temperatur 288–308 K. Dodatkowo, ilościowo oznaczono wybrane markery starzenia chemicznego powstające z tych prekursorów, wykorzystując autentyczne standardy.Wartości kOH,aq​ dla kwasów pinowego i pinonowego były wyższe niż dla kwasów norpinowego, norpinonowego i terpenowego. Wyznaczone energie aktywacji mieściły się w przedziale 9–21 kJ mol⁻¹, typowym dla wodnych reakcji OH z utlenionymi związkami alifatycznymi. Szacowane czasy życia wobec utleniania OH w różnych hydrometeorach malały wraz ze wzrostem zawartości wody ciekłej, co wskazuje, że badane TA mogą ulegać przetwarzaniu w fazie wodnej w realistycznych warunkach atmosferycznych.Zaproponowano mechanizmy reakcji OH z TA pierwszej i wyższych generacji, powstającymi podczas utleniania α-pinenu. Wykazano, że kwas terpenowy może tworzyć się w wyniku wodnej reakcji OH z kwasami norpinowym i pinowym. Jednocześnie reakcja kwasu terpenowego z OH zachodzi niemal dziesięciokrotnie wolniej niż reakcje kwasów pinowego i pinonowego. Sugeruje to, że kwas terpenowy obecny w atmosferze powstaje głównie w wyniku wodnych reakcji OH z TA wczesnej generacji, a nie z jego bezpośredniego utleniania.
DOI: 10.5281/zenodo.18400521
title: Normalized indicators values for the SOS-Water case study for historical and business as usual scenarios

description: These datasets provide the indicators values simulated in each of the SOS-Water project case study for different (historical and business as usual) scenarios, normalized between 0 and 1.

Scenarios:



reference/historical

midcentury - ssp1-2.6

midcentury - ssp2-4.5

midcentury - ssp3-7.0

midcentury - ssp5-8.5

endcentury - ssp1-2.6

endcentury - ssp2-4.5

endcentury - ssp3-7.0

endcentury - ssp5-8.5


Case studies:



Danube basin

Jucar Basin

Rhine Basin

Mekong Delta

Upper Mekong


More information on the indicators and their calculation can be found on the SOS-Water project deliverables (D5.2, D2.3).Raw data (model outputs) used to calculate the indicators values for each case study can be found in the YODA repository of the Utrecht University at the following link https://geo.yoda.uu.nl/research/browse?dir=%2Fresearch-sos-basin-data (accessible upon request).
DOI: 10.5281/zenodo.18400522
title: Normalized indicators values for the SOS-Water case study for historical and business as usual scenarios

description: These datasets provide the indicators values simulated in each of the SOS-Water project case study for different (historical and business as usual) scenarios, normalized between 0 and 1.

Scenarios:



reference/historical

midcentury - ssp1-2.6

midcentury - ssp2-4.5

midcentury - ssp3-7.0

midcentury - ssp5-8.5

endcentury - ssp1-2.6

endcentury - ssp2-4.5

endcentury - ssp3-7.0

endcentury - ssp5-8.5


Case studies:



Danube basin

Jucar Basin

Rhine Basin

Mekong Delta

Upper Mekong


More information on the indicators and their calculation can be found on the SOS-Water project deliverables (D5.2, D2.3).Raw data (model outputs) used to calculate the indicators values for each case study can be found in the YODA repository of the Utrecht University at the following link https://geo.yoda.uu.nl/research/browse?dir=%2Fresearch-sos-basin-data (accessible upon request).
DOI: 10.15468/dl.jm2sww
title: Occurrence Download

description: A dataset containing 15917 species occurrences available in GBIF matching the query:
{
 "DatasetKey" : [
 "is Datos de ocurrencia de triatominos presentes en Argentina del Laboratorio de Triatominos del CEPAVE (CONICET-UNLP)"
 ]
}

 The dataset includes 15917 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0000092-260129131611470/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.aeqwzh
title: Occurrence Download

description: A dataset containing 464 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Pinus albicaulis",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 {
 "or" : [
 "Country is United States of America",
 "Country is Canada"
 ]
 },
 "Year is greater than or equal to 1995",
 "Year is less than or equal to 2005"
 ]
}

 The dataset includes 464 records from 31 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0000093-260129131611470/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.60600/yu/b5awcm
title: Congress: The Electoral Connection

description: Dataset for David R. Mayhew, Congress: The Electoral Connection, 2nd ed. (New Haven, CT: Yale University Press, 2004 (first ed. 1974). Includes histograms for “vanishing marginals” exhibited at pp. 54-60 in David R. Mayhew, Parties and Policies: How the American Government Works (New Haven, CT: Yale University Press, 2008).
DOI: 10.60600/yu/dfle3y
title: The Imprint of Congress

description: Datasets associated with David R. Mayhew, The Imprint of Congress (New Haven, CT: Yale University Press, 2017)
DOI: 10.15468/dl.e6r99c
title: Occurrence Download

description: A dataset containing 117 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Zelkova carpinifolia",
 "HasCoordinate is true",
 "BasisOfRecord is one of (Specimen)"
 ]
}

 The dataset includes 117 records from 24 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0000096-260129131611470/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.26xeuz
title: Occurrence Download

description: A dataset containing 3326015 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is Ireland",
 "OccurrenceStatus is Present",
 "Year 2015-2026"
 ]
}

 The dataset includes 3326015 records from 279 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0000057-260129131611470/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.5281/zenodo.17608495
title: Tectono-climatic driven river avulsion and societal changes in the Late Holocene Central Ganga Basin

description: The following dataset contains XRF, Grain size, Total Organic Carbon and stable carbon isotope data along with age.
DOI: 10.5281/zenodo.18416218
title: Tectono-climatic driven river avulsion and societal changes in the Late Holocene Central Ganga Basin

description: The following dataset contains XRF, Grain size, Total Organic Carbon and stable carbon isotope data along with age.
DOI: 10.15468/dl.44t8hh
title: Occurrence Download

description: A dataset containing 3145 species occurrences available in GBIF matching the query:
{
 "and" : [
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "TaxonKey is Leporinus friderici"
 ]
}

 The dataset includes 3145 records from 98 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0000097-260129131611470/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.5281/zenodo.18416065
title: Data repository for "Spatial autocorrelation of species diversity and distributions in time and across spatial scales"

description: Data repository for the manuscript entitled "Spatial autocorrelation of species diversity and distributions in time and across spatial scales".

The repository contains the following files:



Scripts (*.R and *.qmd): used to produce the analyses and figures of the manuscript. Code 02_get_data, used to download data from the PostgreSQL database, is not included as it has personal information.

sac_grid_occ.rds: matrix of presences and absences used to generate Figure 1.

sac_grid_grain.rds: matrix of presences and absences used to generate Figure 2.

sac_species_table.csv: spatial autocorrelation of the distribution of individual species for all regions, periods and grain sizes (output of Code 06_calculating_species_sac).

sac_richness_table.csv: spatial autocorrelation of richness for all regions, periods and grain sizes (output of Code 07_calculating_richness_sac).

logratio_jcocc.csv: logratio of the observed and expected join count, as well as the occupancy of species distributions (output of Code 09_analyses_sac_occ).

mismatch_taxonomy.csv: species names in the raw atlas data that have since changed, and their updated name following the HBW/BirdLife Taxonomic Checklist (2024, version 9.0).
DOI: 10.5281/zenodo.15463597
title: Data repository for "Spatial autocorrelation of species diversity and distributions in time and across spatial scales"

description: Data repository for the manuscript entitled "Spatial autocorrelation of species diversity and distributions in time and across spatial scales".

The repository contains the following files:



Scripts (*.R and *.qmd): used to produce the analyses and figures of the manuscript. Code 02_get_data, used to download data from the PostgreSQL database, is not included as it has personal information.

sac_grid_occ.rds: matrix of presences and absences used to generate Figure 1.

sac_grid_grain.rds: matrix of presences and absences used to generate Figure 2.

sac_species_table.csv: spatial autocorrelation of the distribution of individual species for all regions, periods and grain sizes (output of Code 06_calculating_species_sac).

sac_richness_table.csv: spatial autocorrelation of richness for all regions, periods and grain sizes (output of Code 07_calculating_richness_sac).

logratio_jcocc.csv: logratio of the observed and expected join count, as well as the occupancy of species distributions (output of Code 09_analyses_sac_occ).

mismatch_taxonomy.csv: species names in the raw atlas data that have since changed, and their updated name following the HBW/BirdLife Taxonomic Checklist (2024, version 9.0).
DOI: 10.15468/dl.ea56hq
title: Occurrence Download

description: A dataset containing 19 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Geometry POLYGON((-4.94941 37.70462,1.00411 37.70462,1.00411 40.08498,-4.94941 40.08498,-4.94941 37.70462))",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 "TaxonKey is Cristarmadillidium muricatum"
 ]
}

 The dataset includes 19 records from 3 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0000098-260129131611470/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.60600/yu/xixnxh
title: Placing Parties

description: Data from David R. Mayhew, Placing Parties in American Politics: Organization, Electoral Settings, and Government Activity in the Twentieth Century (Princeton, NJ: Princeton University Press, 1986)
DOI: 10.5281/zenodo.18416084
title: Flow cytometry raw data for apoptosis analysis in HTR-8/SVneo cells

description: This dataset contains the raw flow cytometry (.fcs) files generated from cell-based experiments in this study. The data were used to quantify apoptotic cell populations under different experimental conditions and support the statistical analyses reported in the associated manuscript.
DOI: 10.5281/zenodo.18416083
title: Flow cytometry raw data for apoptosis analysis in HTR-8/SVneo cells

description: This dataset contains the raw flow cytometry (.fcs) files generated from cell-based experiments in this study. The data were used to quantify apoptotic cell populations under different experimental conditions and support the statistical analyses reported in the associated manuscript.
DOI: 10.60600/yu/h87ash
title: Congressional Elections: The Case of the Vanishing Marginals

description: Data includes histograms from "Congressional Elections: The Case of the Vanishing Marginals," in Polity, Spring, 1974, Vol. 6, No. 3 (Spring, 1974), pp. 295-317
DOI: 10.15468/sdupka
title: Records of brachyuran crabs (Decapoda) from seamounts in the Mariana Ridges, with description of a new species of Samadinia Ng & Richer de Forges, 2013, and rediscovery of Goniopugettia tanakae Sakai, 1986

description: This dataset contains the digitized treatments in Plazi based on the original journal article Komai, Tomoyuki, Tsuchida, Shinji, Fujiwara, Yoshihiro (2025): Records of brachyuran crabs (Decapoda) from seamounts in the Mariana Ridges, with description of a new species of Samadinia Ng & Richer de Forges, 2013, and rediscovery of Goniopugettia tanakae Sakai, 1986. Zootaxa 5722 (3): 326-344, DOI: 10.11646/zootaxa.5722.3.2, URL: https://doi.org/10.11646/zootaxa.5722.3.2AbstractA small collection of brachyuran crabs made during the KM 20-10C cruise conducted by R / V Kaimei of JAMSTEC was studied. The specimens were collected using a suction sampler deployed on the KM-ROV (remotely operated vehicle); four species were identified. Two epialtid species were collected from Ritto Seamount in the West Mariana Ridge: Goniopugettia tanakae Sakai, 1986 at 666 m depth and Samadinia quindecimspina sp. nov. at 617 m depth, each represented by a single male specimen. Goniopugettia tanakae, previously known only from the female holotype of unknown locality, now has its male characteristics and distribution clarified through the present specimen. The generic diagnosis of Goniopugettia is updated. Samadinia quindecimspina sp. nov. appears close to S. griffini (Davie & Short, 1989) from Queensland, Australia, among the 38 known congeners, but is differentiated by its carapace gastric region armature, male pleon shape, and subtle first gonopod features. The remaining two species, Galilia petricola Komai & Tsuchida, 2014 (Leucosiidae) and Beuroisia major (Sakai, 1978) (Mathildellidae), were found at Nikko Seamount in the Central Mariana Ridge. The study also provides genetic data for the mitochondrial 16S rRNA and/or COI genes of these specimens.