cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.26977663
title: Development and evaluation of berberine-loaded bigel for the treatment of hyperpigmentation on B16F10 melanoma cell line

description: <b>Aim:</b> The aim of this study was to optimize, develop, characterize and evaluate a topical nanobigel (BG) formulation containing Berberine (BRB) that exhibits anti-melanogenic properties. <b>Materials & methods:</b> The Berberine-loaded bigel (BRB@BG) formulation was prepared by homogenously mixing the optimized hydrogel and oleogel. BRB@BG was characterized <i>in vitro</i> and cytotoxicity study was conducted to evaluate its effects on murine skin melanoma B16F10 cell lines. <b>Results:</b> The optimized BRB@BG exhibited uniform texture with nanometric size, desirable spreadability and extrudability, suitable for topical applications. Cytotoxicity studies revealed that BRB@BG had a lower IC<sub>50</sub> value (4.84 μg/ml) on B16F10 cell lines compared with drug alone. <b>Conclusion:</b> In conclusion, the developed BRB@BG formulation showed good potential as safe and effective topical treatment for hyperpigmentation. Hyperpigmentation is a common skin disease in which the melanin content becomes abnormally high. The existing treatment options are associated with side effects and therefore research is being aimed to develop a topical nanoformulation based on natural compounds. Berberine (BRB) is one such natural compound that is known to inhibit the production of melanin in skin. This study was aimed to develop a bigel formulation of BRB that can be applied on skin, which can treat the hyperpigmentation and is safe. The developed nanomedicine was found to have all good properties of a topical formulation and was more effective than the drug alone. Various studies on animals were conducted to assess its safety and it was found that the formulation did not show any toxicity to the skin. Berberine, an isoquinoline alkaloid is reported to have antimelanogenic effect but is associated with poor oral bioavailability. Berberine-loaded bigel (BRB@BG) was prepared by homogenously mixing the optimized hydrogel and oleogel. The prepared BRB@BG was characterized using <i>in vitro</i> methods, TEM and trinocular microscopy. Cytotoxicity study was conducted to evaluate the effects of BRB@BG on the murine skin melanoma B16F10 cell lines. Safety of the developed formulation was performed using Draize test followed by histopathology and <i>in ovo</i> irritation studies. The developed formulation showed all desirable properties of an ideal topical formulation. The IC<sub>50</sub> values obtained after cytotoxicity studies was found to be lower than the plain drug showing better efficacy. The developed formulation showed no toxicity in any of the safety evaluation test.
DOI: 10.6084/m9.figshare.26977663.v1
title: Development and evaluation of berberine-loaded bigel for the treatment of hyperpigmentation on B16F10 melanoma cell line

description: <b>Aim:</b> The aim of this study was to optimize, develop, characterize and evaluate a topical nanobigel (BG) formulation containing Berberine (BRB) that exhibits anti-melanogenic properties. <b>Materials & methods:</b> The Berberine-loaded bigel (BRB@BG) formulation was prepared by homogenously mixing the optimized hydrogel and oleogel. BRB@BG was characterized <i>in vitro</i> and cytotoxicity study was conducted to evaluate its effects on murine skin melanoma B16F10 cell lines. <b>Results:</b> The optimized BRB@BG exhibited uniform texture with nanometric size, desirable spreadability and extrudability, suitable for topical applications. Cytotoxicity studies revealed that BRB@BG had a lower IC<sub>50</sub> value (4.84 μg/ml) on B16F10 cell lines compared with drug alone. <b>Conclusion:</b> In conclusion, the developed BRB@BG formulation showed good potential as safe and effective topical treatment for hyperpigmentation. Hyperpigmentation is a common skin disease in which the melanin content becomes abnormally high. The existing treatment options are associated with side effects and therefore research is being aimed to develop a topical nanoformulation based on natural compounds. Berberine (BRB) is one such natural compound that is known to inhibit the production of melanin in skin. This study was aimed to develop a bigel formulation of BRB that can be applied on skin, which can treat the hyperpigmentation and is safe. The developed nanomedicine was found to have all good properties of a topical formulation and was more effective than the drug alone. Various studies on animals were conducted to assess its safety and it was found that the formulation did not show any toxicity to the skin. Berberine, an isoquinoline alkaloid is reported to have antimelanogenic effect but is associated with poor oral bioavailability. Berberine-loaded bigel (BRB@BG) was prepared by homogenously mixing the optimized hydrogel and oleogel. The prepared BRB@BG was characterized using <i>in vitro</i> methods, TEM and trinocular microscopy. Cytotoxicity study was conducted to evaluate the effects of BRB@BG on the murine skin melanoma B16F10 cell lines. Safety of the developed formulation was performed using Draize test followed by histopathology and <i>in ovo</i> irritation studies. The developed formulation showed all desirable properties of an ideal topical formulation. The IC<sub>50</sub> values obtained after cytotoxicity studies was found to be lower than the plain drug showing better efficacy. The developed formulation showed no toxicity in any of the safety evaluation test.
DOI: 10.6084/m9.figshare.26977675
title: Adapting to the acidic environment of the NP: RADA16-PLGA (TGF-β3) induces chondrogenic differentiation of BMSCs

description: <b>Aim:</b> RADA16-PLGA composite scaffolds constructed with simultaneous loading of BMSCs and TGF-β3 and explored their ability for chondrogenic differentiation <i>in vitro</i>. <b>Methods:</b> The performance of the composite scaffolds is assessed by rheometer assay, electron microscopic structural observation and ELISA release assay. The biosafety of the composite scaffolds is assessed by cytocompatibility assay and cell migration ability. The chondrogenic differentiation ability of composite scaffolds is evaluated by Alisin blue staining, PCR and immunofluorescence staining. <b>Results:</b> The composite scaffold has a good ECM-like structure, the ability to control the release of TGF-β3 and good biocompatibility. More importantly, the composite scaffolds can induce the differentiation of BMSCs to chondrocytes. <b>Conclusion:</b> Composite scaffolds are expected to enhance the endogenous NP repair process. RADA16 aqueous solution, PLGA microspheres and BMSCs are mixed to form a composite aqueous solution. The aqueous solution is injected into the body and exposed to the acidic environment of the NP. The nucleus pulposus pH induces gelation of the aqueous solution to form a composite scaffold. The composite scaffold can function <i>in vivo</i>. It induces the differentiation of BMSCs into chondrocytes and subsequently secretes a large amount of ECM such as Collagen II, GAGAs and SOX-9. In addition, it also enhances the self-repair of endogenous BMSCs, which is to replenish the reduction of nucleus pulposus cells and the loss of ECM. There is an endogenous repair process during myeloid degeneration, but there is an insufficient number of stem cells and a lack of sustained release of growth factors. BMSCs can differentiate into chondrocytes and secrete extracellular matrix in response to TGFβ3. The physico-mechanical properties and ultrastructure of the RADA16 hydrogel meet the requirements of the target material. The suitable conditions for RADA16 are 1% w/v and pH = 7.0. The RADA16-PLGA hydrogel-microsphere composite scaffold structure can encapsulate TGF-β3 to form a good controlled release system. The suitable conditions for the composite scaffold are 1% w/v and pH = 7.0. Composite scaffolds have good cytocompatibility. Composite scaffolds can recruit BMSCs for migration to the composite scaffold. The composite scaffold can adapt to the acidic environment of the degenerated disc, inducing the differentiation of BMSCs to chondrocyte-like cells while secreting large amounts of ECM. Composite scaffolds are expected to enhance the endogenous NP repair process and are promising tissue-engineered scaffolds for IVDD repair.
DOI: 10.6084/m9.figshare.26977675.v1
title: Adapting to the acidic environment of the NP: RADA16-PLGA (TGF-β3) induces chondrogenic differentiation of BMSCs

description: <b>Aim:</b> RADA16-PLGA composite scaffolds constructed with simultaneous loading of BMSCs and TGF-β3 and explored their ability for chondrogenic differentiation <i>in vitro</i>. <b>Methods:</b> The performance of the composite scaffolds is assessed by rheometer assay, electron microscopic structural observation and ELISA release assay. The biosafety of the composite scaffolds is assessed by cytocompatibility assay and cell migration ability. The chondrogenic differentiation ability of composite scaffolds is evaluated by Alisin blue staining, PCR and immunofluorescence staining. <b>Results:</b> The composite scaffold has a good ECM-like structure, the ability to control the release of TGF-β3 and good biocompatibility. More importantly, the composite scaffolds can induce the differentiation of BMSCs to chondrocytes. <b>Conclusion:</b> Composite scaffolds are expected to enhance the endogenous NP repair process. RADA16 aqueous solution, PLGA microspheres and BMSCs are mixed to form a composite aqueous solution. The aqueous solution is injected into the body and exposed to the acidic environment of the NP. The nucleus pulposus pH induces gelation of the aqueous solution to form a composite scaffold. The composite scaffold can function <i>in vivo</i>. It induces the differentiation of BMSCs into chondrocytes and subsequently secretes a large amount of ECM such as Collagen II, GAGAs and SOX-9. In addition, it also enhances the self-repair of endogenous BMSCs, which is to replenish the reduction of nucleus pulposus cells and the loss of ECM. There is an endogenous repair process during myeloid degeneration, but there is an insufficient number of stem cells and a lack of sustained release of growth factors. BMSCs can differentiate into chondrocytes and secrete extracellular matrix in response to TGFβ3. The physico-mechanical properties and ultrastructure of the RADA16 hydrogel meet the requirements of the target material. The suitable conditions for RADA16 are 1% w/v and pH = 7.0. The RADA16-PLGA hydrogel-microsphere composite scaffold structure can encapsulate TGF-β3 to form a good controlled release system. The suitable conditions for the composite scaffold are 1% w/v and pH = 7.0. Composite scaffolds have good cytocompatibility. Composite scaffolds can recruit BMSCs for migration to the composite scaffold. The composite scaffold can adapt to the acidic environment of the degenerated disc, inducing the differentiation of BMSCs to chondrocyte-like cells while secreting large amounts of ECM. Composite scaffolds are expected to enhance the endogenous NP repair process and are promising tissue-engineered scaffolds for IVDD repair.
DOI: 10.5281/zenodo.13739149
title: Dataset (Part III) accompanying the paper "In the brain of the beholder: bi-stable motion reveals mesoscopic-scale feedback modulation in V1"

description: This is Part III of the dataset (sub-10).  Due to size constraints, the remaining subjects can be found in the following records: Dataset (Part I) accompanying the paper 'In the Brain of the Beholder: Bi-Stable Motion Reveals Mesoscopic-Scale Feedback Modulation in V1' (from sub-01 to sub-05) and Dataset (Part II) accompanying the paper 'In the Brain of the Beholder: Bi-Stable Motion Reveals Mesoscopic-Scale Feedback Modulation in V1' (from sub-06 to sub-09)
DOI: 10.5281/zenodo.13739150
title: Dataset (Part III) accompanying the paper "In the brain of the beholder: bi-stable motion reveals mesoscopic-scale feedback modulation in V1"

description: This is Part III of the dataset (sub-10).  Due to size constraints, the remaining subjects can be found in the following records: Dataset (Part I) accompanying the paper 'In the Brain of the Beholder: Bi-Stable Motion Reveals Mesoscopic-Scale Feedback Modulation in V1' (from sub-01 to sub-05) and Dataset (Part II) accompanying the paper 'In the Brain of the Beholder: Bi-Stable Motion Reveals Mesoscopic-Scale Feedback Modulation in V1' (from sub-06 to sub-09)
DOI: 10.15468/dl.hnsyus
title: Occurrence Download

description: A dataset containing 10758 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Continent is South America",
 "TaxonKey is Ormosia Jacks."
 ]
}

 The dataset includes 10758 records from 343 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0010353-240906103802322/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.j66sat
title: Occurrence Download

description: A dataset containing 48 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Continent is Africa",
 "Country is Benin",
 "TaxonKey is Bombax costatum Pellegr. & Vuillet",
 "Year 2022-2024"
 ]
}

 The dataset includes 48 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0010354-240906103802322/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.5517/ccdc.csd.cc2bflft
title: CCDC 2158016: Experimental Crystal Structure Determination

description: Related Article: Hans Renata, Yanlong Jiang|2024|Nature Chemistry|16|1531|doi:10.1038/s41557-024-01533-w
description: Related Article: Hans Renata, Yanlong JIANG|2024|U.S.Patents|||
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.15468/dl.y5srsa
title: Occurrence Download

description: A dataset listing the 216 species recorded in GBIF matching the query:
{
 "DatasetKey" : [
 "is Inland water macroinvertebrate occurrences in Flanders, Belgium"
 ]
}

 The dataset's 216 records were derived from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0010330-240906103802322/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.6084/m9.figshare.26796153
title: Supplementary tables for Thermal tolerance traits of individual corals are widely distributed across the Great Barrier Reef

description: Supporting metadata and statistical test results for the analyses presented in the manuscript.
DOI: 10.6084/m9.figshare.26796153.v1
title: Supplementary tables for Thermal tolerance traits of individual corals are widely distributed across the Great Barrier Reef

description: Supporting metadata and statistical test results for the analyses presented in the manuscript.
DOI: 10.15468/dl.mb52wh
title: Occurrence Download

description: A dataset containing 1640178 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is one of (Alliaria petiolata (M.Bieb.) Cavara & Grande, Alnus glutinosa (L.) Gaertn., Alopecurus myosuroides Huds.)"
 ]
}

 The dataset includes 1640178 records from 3843 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0010326-240906103802322/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.k7g3d7
title: Occurrence Download

description: A dataset containing 12461 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Ecklonia Hornemann, 1828",
 "OccurrenceStatus is Present",
 "HasCoordinate is true",
 "Geometry POLYGON((20 -60,180 -60,180 -20,20 -20,20 -60))"
 ]
}

 The dataset includes 12461 records from 46 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0173449-230224095556074/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.d0gnbo
title: Occurrence Download

description: A dataset containing 72 species occurrences available in GBIF matching the query:
{
 "and" : [
 {
 "or" : [
 "Country is Uganda",
 "Country is Rwanda",
 "Country is Congo, Democratic Republic of the"
 ]
 },
 "HasCoordinate is true",
 "TaxonKey is Gorilla beringei beringei",
 "HasGeospatialIssue is false"
 ]
}

 The dataset includes 72 records from 2 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0011556-191105090559680/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.wtol9c
title: Occurrence Download

description: A dataset containing 10445 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Polioptila plumbea (Gmelin, 1788)"
 ]
}

 The dataset includes 10445 records from 62 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0001971-150221044754056/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.2sy735
title: Occurrence Download

description: A dataset containing 5 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Piper amphitrichum Trel."
 ]
}

 The dataset includes 5 records from 3 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0185637-240321170329656/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.xeaxrh
title: Occurrence Download

description: A dataset containing 205 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Dicliptera scutellata Griseb."
 ]
}

 The dataset includes 205 records from 29 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0173373-230224095556074/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.8lxvwg
title: Occurrence Download

description: A dataset containing 1690104 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is France",
 "TaxonKey is Lepidoptera"
 ]
}

 The dataset includes 1690104 records from 514 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0011560-191105090559680/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.5tn7po
title: Occurrence Download

description: A dataset containing 438896 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Tringa melanoleuca (J.F.Gmelin, 1789)",
 "HasCoordinate is true",
 "HasGeospatialIssue is false"
 ]
}

 The dataset includes 438896 records from 104 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0001971-150330110031120/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.t6vne5
title: Occurrence Download

description: A dataset listing the 292 species recorded in GBIF matching the query:
{
 "and" : [
 "Geometry POLYGON((-2.08407 53.7144,-1.9502 53.7144,-1.9502 53.77791,-2.08407 53.77791,-2.08407 53.7144))",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 "TaxonKey is Bryophyta"
 ]
}

 The dataset's 292 records were derived from 7 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0173429-230224095556074/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.mmaac9
title: Occurrence Download

description: A dataset containing 43262 species occurrences available in GBIF matching the query:
{
 "and" : [
 "DatasetKey is The birds collection (ZO) of the Muséum national d'Histoire Naturelle (MNHN - Paris)"
 ]
}

 The dataset includes 43262 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0028491-191105090559680/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.ex6def
title: Occurrence Download

description: A dataset containing 8 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Pitcairnia condorensis Manzan. & W.Till"
 ]
}

 The dataset includes 8 records from 3 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0185636-240321170329656/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.vy11wz
title: Occurrence Download

description: A dataset containing 18139 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Arthropoda",
 "Country is Morocco"
 ]
}

 The dataset includes 18139 records from 151 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0001971-150504100648427/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.osvuqs
title: Occurrence Download

description: A dataset containing 5337 species occurrences available in GBIF matching the query:
{
 "and" : [
 "DatasetKey is Suivis télémétriques des pinnipèdes dans les TAAF du Centre d'Etudes Biologiques de Chizé - Suivis télémétriques des éléphants de mer dans les TAAF par le Centre d'Etudes Biologiques de Chizé"
 ]
}

 The dataset includes 5337 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0028492-191105090559680/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.gyvxdp
title: Occurrence Download

description: A dataset containing 10980 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Polygonia c-aureum (Linnaeus, 1758)"
 ]
}

 The dataset includes 10980 records from 118 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0173526-230224095556074/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.moy9l8
title: Occurrence Download

description: A dataset containing 96445 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Alliaria petiolata (M.Bieb.) Cavara & Grande",
 "Geometry POLYGON((-27 26,-27 71,84 71,84 26,-27 26))",
 "HasGeospatialIssue is false"
 ]
}

 The dataset includes 96445 records from 451 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0001971-150528172251762/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.up8gzq
title: Occurrence Download

description: A dataset containing 564 species occurrences available in GBIF matching the query:
{
 "and" : [
 "GadmGid is one of (MEX.27.16_2, MEX.27.15_2, MEX.27.9_2)",
 "IucnRedListCategory is one of (VU, EN, CR)"
 ]
}

 The dataset includes 564 records from 63 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0185634-240321170329656/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.