cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.24258349
title: Supplementary Material for: Explorative clustering of the nitrogen balance trajectory in critically ill patients: A preliminary post-hoc analysis of a single center prospective observational study

description: Background: The nitrogen balance estimates a protein net difference. However, since it has a number of limitations, it is important to consider the trajectory of the nitrogen balance in the clinical course of critically ill patients. Objectives: We herein exploratively classified the nitrogen balance trajectory using a machine learning method. Method: This is a post-hoc analysis of a single-center prospective study for the patients admitted to our Emergency and Critical Center ICU. The nitrogen balance was evaluated with 24-hour urine collection from ICU days 1 to 10 with 9 points. K-means clustering was performed to classify the nitrogen balance trajectory. We also evaluated factors associated with uncovered clusters. Results: Seventy-six eligible patients were included in the present study. After clustering, the nitrogen balance trajectory was classified into 4 classes. Class 1 was trajected as a negative balance over 10 days (24 patients). Class 2 had a positive conversion on day 3 or 4 (8 patients). Class 3 had a positive conversion on day 8 or 9 (28 patients). Class 4 initially had a positive balance and then converted to a negative balance (16 patients). Sepsis complication and steroid use were associated with negative nitrogen balance trajectory. Class 2 was associated with lower length of hospital stay and femoral muscle volume loss, however, frequently had frailty and sarcopenia on admission. Active nutrition therapy intention was not corelated with positive trajectory. Conclusions: The nitrogen balance trajectory in critically ill patients may be classified into 4 classes for clinical practice. Among patients emergently admitted to the ICU, the positive conversion of the nitrogen balance might be delayed over 10 days.
DOI: 10.6084/m9.figshare.24258349.v1
title: Supplementary Material for: Explorative clustering of the nitrogen balance trajectory in critically ill patients: A preliminary post-hoc analysis of a single center prospective observational study

description: Background: The nitrogen balance estimates a protein net difference. However, since it has a number of limitations, it is important to consider the trajectory of the nitrogen balance in the clinical course of critically ill patients. Objectives: We herein exploratively classified the nitrogen balance trajectory using a machine learning method. Method: This is a post-hoc analysis of a single-center prospective study for the patients admitted to our Emergency and Critical Center ICU. The nitrogen balance was evaluated with 24-hour urine collection from ICU days 1 to 10 with 9 points. K-means clustering was performed to classify the nitrogen balance trajectory. We also evaluated factors associated with uncovered clusters. Results: Seventy-six eligible patients were included in the present study. After clustering, the nitrogen balance trajectory was classified into 4 classes. Class 1 was trajected as a negative balance over 10 days (24 patients). Class 2 had a positive conversion on day 3 or 4 (8 patients). Class 3 had a positive conversion on day 8 or 9 (28 patients). Class 4 initially had a positive balance and then converted to a negative balance (16 patients). Sepsis complication and steroid use were associated with negative nitrogen balance trajectory. Class 2 was associated with lower length of hospital stay and femoral muscle volume loss, however, frequently had frailty and sarcopenia on admission. Active nutrition therapy intention was not corelated with positive trajectory. Conclusions: The nitrogen balance trajectory in critically ill patients may be classified into 4 classes for clinical practice. Among patients emergently admitted to the ICU, the positive conversion of the nitrogen balance might be delayed over 10 days.
DOI: 10.25919/7v0n-hq80
title: Parkes observations for project P1183 semester 2023APRS_24

description: A new energetic repeating FRB 20220529 can be observed by both FAST and Parkes telescopes and the simultaneous observing time is up to one hour. We have observed this source using Parkes UWL green time and in total 21 bursts have been detected. Two bursts of them have the corresponding simultaneous FAST observations. Only one burst has 4-pol datasets and is bright enough to analyse the polarization properties. Therefore, we propose to continue the monitoring of the source of FRB 20220529 using the Parkes UWL with high-time resolution and 4-pol observation. The new proposed observation aims to: (1)detect more bursts by Parkes UWL with full polarization information; (2) detect more bursts by Parkes UWL with corresponding simultaneous FAST observations; (3) study the radiation spectrum by more bursts detected in simultaneous observations of Parkes and FAST; (4) study the burst microstructure using high time resolution datasets, and (5) study the frequency ranges changes of the repeating bursts.
DOI: 10.25919/ge3c-at32
title: Parkes observations for project P1193 semester 2023APRS_06

description: In a search for steep spectrum sources in the combined data from the Rapid ASKAP Continuum Survey Low-band (RACS-low at 888 MHz) and high-band (RACS-high at 1667 MHz), we have found 14 compact objects with an ultra steep radio spectrum (\alpha &lt; -1.6) and matched with a Fermi unassociated source. Sources with ultra steep radio spectra and gamma-ray emission are likely to be previously unidentified pulsars. We propose to observe these targets with Murriyang (Parkes) UWL receiver. The deep targeted pulsar search will help us confirm new pulsars in extreme systems or environments, such as pulsars in compact binaries, and highly scattered pulsars.
DOI: 10.6084/m9.figshare.24258388
title: Supplementary Material for: Efficacy and Safety of Mechanical Thrombectomy in Elderly and Non-Elderly Patients with Large Vessel Occlusion Stroke A Systematic Review and Meta-Analysis

description: INTRODUCTION Mechanical thrombectomy (MT) is recommended for large vessel occlusion (LVO) stroke. However, most of the studies that investigated the superiority of MT over best medical management (BMM) alone included preponderantly non-elderly patients. Thus, there is uncertainty in relation to the efficacy of MT in the elderly. We aim to compare the effect of BMM to BMM plus (MT) among elderly and non-elderly patients with (LVO). METHODS We performed a systematic search of medical databases from inception to April 2023 to identify randomized studies that reported the functional outcome at 90 days by age for patients with LVO treated with MT vs. BMM. Patients were divided into elderly (&gt;70 or &gt;80 years, depending on the cut-off used in each study) and non-elderly. Outcomes were defined as excellent (modified Rankin Scale [mRS]≤1), good (mRS≤3), poor (mRS≥5), or death. Effect sizes were calculated by using random effects meta-analyses. Results were represented by odds ratio (OR) and their 95% confidence intervals (95% CI). RESULTS A total of 2,195 patients were included in the analysis (≥70 years, 7 trials, n= 696; ≥80 years, 2 trials, n=139). Non-elderly patients treated with MT had higher odds of excellent outcome (OR 3.05; 95% CI 2.23-4.18) and good outcome (OR 2.70; 95% CI 1.94-3.74), and lower odds of poor outcome (OR 0.54; 95% CI 0.40-0.72) and death (OR 0.63; 95% CI 0.41-0.96). Similarly, elderly patients treated with MT had higher odds of excellent (OR 2.39; 95% CI 1.05-5.45) and good outcomes (OR 2.18; 95% CI 1.43-3.33) and lower odds of poor outcome (OR 0.48; 95% CI 0.33-0.70) and mortality (OR 0.50; 0.26-0.95). When outcomes were analyzed by age subgroups, MT was associated with higher odds of good outcome in patients ≥70 years (OR 1.95, 95% CI 1.26-3.03) and ≥80 years (OR 4.43, 95% CI 1.02-19.23). DISCUSSION/CONCLUSION MT increases the likelihood of achieving a good outcome in elderly and non-elderly patients without increasing the risk of severe disability or death. MT, when otherwise clinically indicated, should be considered over BMM alone in both age groups.
DOI: 10.6084/m9.figshare.24258388.v1
title: Supplementary Material for: Efficacy and Safety of Mechanical Thrombectomy in Elderly and Non-Elderly Patients with Large Vessel Occlusion Stroke A Systematic Review and Meta-Analysis

description: INTRODUCTION Mechanical thrombectomy (MT) is recommended for large vessel occlusion (LVO) stroke. However, most of the studies that investigated the superiority of MT over best medical management (BMM) alone included preponderantly non-elderly patients. Thus, there is uncertainty in relation to the efficacy of MT in the elderly. We aim to compare the effect of BMM to BMM plus (MT) among elderly and non-elderly patients with (LVO). METHODS We performed a systematic search of medical databases from inception to April 2023 to identify randomized studies that reported the functional outcome at 90 days by age for patients with LVO treated with MT vs. BMM. Patients were divided into elderly (&gt;70 or &gt;80 years, depending on the cut-off used in each study) and non-elderly. Outcomes were defined as excellent (modified Rankin Scale [mRS]≤1), good (mRS≤3), poor (mRS≥5), or death. Effect sizes were calculated by using random effects meta-analyses. Results were represented by odds ratio (OR) and their 95% confidence intervals (95% CI). RESULTS A total of 2,195 patients were included in the analysis (≥70 years, 7 trials, n= 696; ≥80 years, 2 trials, n=139). Non-elderly patients treated with MT had higher odds of excellent outcome (OR 3.05; 95% CI 2.23-4.18) and good outcome (OR 2.70; 95% CI 1.94-3.74), and lower odds of poor outcome (OR 0.54; 95% CI 0.40-0.72) and death (OR 0.63; 95% CI 0.41-0.96). Similarly, elderly patients treated with MT had higher odds of excellent (OR 2.39; 95% CI 1.05-5.45) and good outcomes (OR 2.18; 95% CI 1.43-3.33) and lower odds of poor outcome (OR 0.48; 95% CI 0.33-0.70) and mortality (OR 0.50; 0.26-0.95). When outcomes were analyzed by age subgroups, MT was associated with higher odds of good outcome in patients ≥70 years (OR 1.95, 95% CI 1.26-3.03) and ≥80 years (OR 4.43, 95% CI 1.02-19.23). DISCUSSION/CONCLUSION MT increases the likelihood of achieving a good outcome in elderly and non-elderly patients without increasing the risk of severe disability or death. MT, when otherwise clinically indicated, should be considered over BMM alone in both age groups.
DOI: 10.6084/m9.figshare.24210759
title: G2AN_TM12.5_G_rotate_filter

description: The NeuroGT (neurogenic tagging) database provides images of whole-brain sections of mice in which neurons that differentiated at a similar time have been genetically tagged. The images of brain sections are displayed in order from the anterior to the posterior end on a web-browser, and the regions containing tagged neurons can be visually confirmed. However, it has been difficult to grasp their location in three-dimensional (3D) space. As a first step toward quantitative analysis of neuronal location, we automatically detected regions of mouse brains containing tagged neurons by using image processing and integrated that information into 3D space. We confirmed that the proposed methods detected brain regions with an average precision of 88% and average recall of 99%. We achieved visualization of 3D reconstructed brain shapes and distribution of tagged neurons in the regions of the brain.
DOI: 10.6084/m9.figshare.24210759.v1
title: G2AN_TM12.5_G_rotate_filter

description: The NeuroGT (neurogenic tagging) database provides images of whole-brain sections of mice in which neurons that differentiated at a similar time have been genetically tagged. The images of brain sections are displayed in order from the anterior to the posterior end on a web-browser, and the regions containing tagged neurons can be visually confirmed. However, it has been difficult to grasp their location in three-dimensional (3D) space. As a first step toward quantitative analysis of neuronal location, we automatically detected regions of mouse brains containing tagged neurons by using image processing and integrated that information into 3D space. We confirmed that the proposed methods detected brain regions with an average precision of 88% and average recall of 99%. We achieved visualization of 3D reconstructed brain shapes and distribution of tagged neurons in the regions of the brain.
DOI: 10.6084/m9.figshare.24210750.v1
title: G2AN_TM12.5_G_target_contour

description: The NeuroGT (neurogenic tagging) database provides images of whole-brain sections of mice in which neurons that differentiated at a similar time have been genetically tagged. The images of brain sections are displayed in order from the anterior to the posterior end on a web-browser, and the regions containing tagged neurons can be visually confirmed. However, it has been difficult to grasp their location in three-dimensional (3D) space. As a first step toward quantitative analysis of neuronal location, we automatically detected regions of mouse brains containing tagged neurons by using image processing and integrated that information into 3D space. We confirmed that the proposed methods detected brain regions with an average precision of 88% and average recall of 99%. We achieved visualization of 3D reconstructed brain shapes and distribution of tagged neurons in the regions of the brain.
DOI: 10.6084/m9.figshare.24210750
title: G2AN_TM12.5_G_target_contour

description: The NeuroGT (neurogenic tagging) database provides images of whole-brain sections of mice in which neurons that differentiated at a similar time have been genetically tagged. The images of brain sections are displayed in order from the anterior to the posterior end on a web-browser, and the regions containing tagged neurons can be visually confirmed. However, it has been difficult to grasp their location in three-dimensional (3D) space. As a first step toward quantitative analysis of neuronal location, we automatically detected regions of mouse brains containing tagged neurons by using image processing and integrated that information into 3D space. We confirmed that the proposed methods detected brain regions with an average precision of 88% and average recall of 99%. We achieved visualization of 3D reconstructed brain shapes and distribution of tagged neurons in the regions of the brain.
DOI: 10.5067/gflnd-3c624
title: CSR TELLUS GRACE-FO Level-3 Monthly Land Water-Equivalent-Thickness Surface Mass Anomaly Release 6.2 version 04
DOI: 10.5067/gfocn-3c624
title: CSR TELLUS GRACE-FO Level-3 Monthly Ocean Bottom Pressure Anomaly Release 6.2 version 04
DOI: 10.26179/wty1-2s19
title: Analysis notes for BHC1 and BHC2 ice cores, taken from Law Dome
DOI: 10.17894/ucph.48227096-1bcf-4c57-a7c5-d478bcef59bd
title: Dataset for Smith-Hall et al 2023 in PNAS Nexus

description: This is the data used for calculations in the paper "The sustainability of trade in wild plants – a data-integration approach tested on critically endangered Nardostachys jatamansi" by Smith-Hall et al (2023) in PNAS Nexus. It consists of (i) district-level MaxEnt data on Nardostachys jatamansi distribution in Nepal, (ii) province and district level data on the trade in air-dry rhizomes of N. jatamansi in Nepal, and (iii) district-level forest area data for Nepal.
DOI: 10.3886/e184161v1-142086
title: Data and Code for: Does Identity Affect Labor Supply?

description: How does identity influence economic behavior in the labor market? I investigate this question in rural India, focusing on the effect of caste identity on job-specific labor supply. In a field experiment, laborers choose whether to take up various job offers, which differ in associations with specific castes. Workers are less willing to accept offers that are linked to castes other than their own, especially when those castes rank lower in the social hierarchy. Workers forego large payments to avoid job offers that conflict with their caste identity, even when these decisions are made in private.
description: Male casual daily-wage laborers living in Odisha, India.
description: Data were collected via in-person surveys using paper instruments. The data was double entered using the Cylon software (https://github.com/cylondata/cylon), by two different data entry officers, to reduce errors.
DOI: 10.5281/zenodo.6983188
title: SPAAM Summer School 2022: Introduction to Ancient Metagenomics - 5c Introduction to Functional Profiling

description: Teaching data for practical session: "5c Introduction to Functional Profiling" of the 2022 SPAAM Summer School: Introduction to Ancient Metagenomics (Aug. 1-5 2022). See: https://spaam-community.github.io/wss-summer-school/#/2022/ or https://doi.org/10.5281/zenodo.6976711 for slides. Once downloaded, run: <pre><code>tar xvfz &lt;session&gt;.tar.gz</code></pre> to decompress the data directory for the session. This updated version changes the conda environment due to versioning conflicts.
DOI: 10.5281/zenodo.6983189
title: SPAAM Summer School 2022: Introduction to Ancient Metagenomics - 5c Introduction to Functional Profiling

description: Teaching data for practical session: "5c Introduction to Functional Profiling" of the 2022 SPAAM Summer School: Introduction to Ancient Metagenomics (Aug. 1-5 2022). See: https://spaam-community.github.io/wss-summer-school/#/2022/ or https://doi.org/10.5281/zenodo.6976711 for slides. Once downloaded, run: <pre><code>tar xvfz &lt;session&gt;.tar.gz</code></pre> to decompress the data directory for the session.
DOI: 10.5281/zenodo.8412642
title: SPAAM Summer School 2022: Introduction to Ancient Metagenomics - 5c Introduction to Functional Profiling

description: Teaching data for practical session: "5c Introduction to Functional Profiling" of the 2022 SPAAM Summer School: Introduction to Ancient Metagenomics (Aug. 1-5 2022). See: https://spaam-community.github.io/wss-summer-school/#/2022/ or https://doi.org/10.5281/zenodo.6976711 for slides. Once downloaded, run: <pre><code>tar xvfz &lt;session&gt;.tar.gz</code></pre> to decompress the data directory for the session. This updated version changes the conda environment due to versioning conflicts.
DOI: 10.25919/rzh6-w822
title: Parkes observations for project P1185 semester 2023APRS_18

description: Ultra-long period neutron stars (ULPNSs) are an emerging class of objects that have sparked interest and curiosity in the fast transient community. Along with standard magnetars, they have been theorised to be potential progenitors of the enigmatic fast radio bursts (FRBs). The MeerTRAP project at the MeerKAT radio telescope is uncovering several magnetar and ultra-long period neutron star candidates, an example of which is PSR J0901-4046 with a period of 76s. Continued long-term monitoring of PSR J0901-4046 has shown it to be potentially transitioning into radio quiescence. The proposed observations will enable us to continue to monitor and characterise the decline in flux density. We have also discovered two new candidates MTP0027 and MTP0068 with periods of ~10 seconds and ~5 seconds respectively. Both sources exhibit magnetar-like pulse morphology and have only been detected in one epoch with MeerKAT. We propose to continue monitoring these sources to re-detect pulses and study their spectro-temporal-polarimetric properties.
DOI: 10.6084/m9.figshare.24258418
title: Source data.zip

description: The data source for "Imperceptive and Reusable Dermal Surface EMG for Lower Extremity Neuro-Prosthetic Control and Clinical Assessment"<br>
DOI: 10.15151/esrf-es-1303535376
title: BAG for Signal transduction, DNA repair, marine & structural glycobiology, bacterial polyketide synthases, starch biosynthesis, regulation o

description: BAG regrouping small crystallographic teams at Lille, Orléans, Roscoff, Nancy and Marseille. For all projects both SAXS and MX-crystallography studies are required to cover different aspects and scales of these often multimodular proteins. The projects in Lille concern Type V secretion systems, Sars-Cov proteins, regulatory networks of signal transduction, starch metabolism (synthesis) and structural glycobiology. In Roscoff the projects concern marine glycobiology and marine phage proteins, deciphering functions of 'unknown' proteins and PUL assemblages. The projects treated in Orléans are DNA structure and repair, transcription regulation, molecular mechanisms of oxidative stress; in Nancy the studies concern the regulation and mechanisms of prokaryotic polyketide syntheses. The subjects of Marseille are SAXS studies of ordered and disordered proteins involved in regulation of CO2 assimilation in microalgae.
DOI: 10.15151/esrf-es-1308545299
title: BAG Montpellier

description: The BAG of Montpellier gathers researchers from distinct institutes (CBS, IGF, IRIM and LPHI) affiliated to the INSERM, the CNRS and the university of Montpellier. The CBS is a node of the national infrastructure FRISBI. In this context, it is developping new methodologies for efficient ligand screening by X-ray diffraction. It is also involved in solving the structure of novel therapeutic targets to develop novel drug candidates. The IGF is involved in characterizing membrane proteins (mainly GPCRs) in order to better understand their functioning for therapeutic application. The IRIM and LPHI are focusing on several therapeutic targets related to infectious diseases in order to identify and develop novel inhibitors. CBS and IGF use SAXS to unravel the organization and behavior of various macromolecular systems in solution. Finally, we also use cryo-electron microscopy to study some macromolecular assemblies.
DOI: 10.15151/esrf-es-1308732081
title: BAG for the Structural Biology Groups in Madrid

description: This proposal is a collaborative effort of the Structural Biology Groups of Madrid with the objective to form a strong core of scientist devoted to this area of research in Spain. It is composed of 21 groups distributed in 4 research Institutes.
DOI: 10.15151/esrf-es-1304367673
title: Munich Crystallography BAG

description: The diverse groups of the Munich Crystallography BAG study a far range of subjects, reaching from structural aspects of fundamental cellular processes - such as RNA processing, protein folding and degradation, DNA repair, chromatin remodelling, enzymes - to the design of foldamers. The research groups are located at the LMU and TUM universities in Munich, at the Max-Planck-Institute of Biochemistry, Martinsried, and the Helmholtz Center, Neuherberg. Out-groups are located at the universities in Darmstadt and Ulm, Germany. The research groups use X-ray crystallography, single-particle cryo-EM, SAXS, NMR and HDX and XL-MS mass-spectrometry for structural studies.
DOI: 10.15151/esrf-es-1347762760
title: Structure of metalloproteins, membrane proteins, filamentous sarcomer proteins, and virus particles

description: Our work focusses on biological nitrogen fixation by Nitrogenase, on metalloenzymes and integral membrane proteins of bacterial and archaeal respiratory systems (Andrade/Einsle/Wohlwend), the working mechanism and regulation of medically relevant membrane proteins and complexes and their defects leading to pathologies (Hunte), bacterial antibiotic resistance factors and viral and bacterial proteins bound to their targets or inhibitors, and their interactions with glycans (Stehle/Zocher), human S100 proteins involved in nutritional immunity, USP18 enforcing the endogenous antiviral interferon response, and the respiratory complex NQR of V. cholerae (Fritz), DNA Polymerases with artificial substrates (Benz), and on multi-domain components of the sarcomeric filamentous protein titin and their binding to the E3 ubiquitin ligase MuRF1 and the central myosin rod-domain (Mayans).