cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.7931777
title: MiR-195 regulates mitochondrial function by targeting mitofusin-2 in breast cancer cells

description: Mitochondrial dynamics is a highly dysregulated process in cancer. Apoptosis and mitochondrial fission are two concurrent events wherein increased mitochondrial fragmentation serves as a hallmark of apoptosis. We have shown earlier that miR-195 exerts pro-apoptotic effects in breast cancer cells. Herein, we have demonstrated miR-195 as a modulator of mitochondrial dynamics and function. Imaging experiments upon miR-195 treatment have shown that mitochondria undergo extensive fission. We validated mitofusin2 as a potential target of miR-195. This may provide a molecular explanation for the respiratory defects induced by miR-195 over-expression in breast cancer cells. Active, but not total, mitochondrial mass, was reduced with increasing levels of miR-195. We have further shown that miR-195 enhances mitochondrial SOD-2 expression but does not affect PINK1 levels in breast cancer cells. Collectively, we have revealed that miR-195 is a modulator of mitochondrial dynamics by targeting MFN2 thereby impairing mitochondrial function. Concomitantly, it enhances the scavenger of reactive oxygen species (SOD-2) to maintain moderate levels of oxidative stress. Our findings suggest a therapeutic potential of miR-195 in both ER-positive as well as ER-negative breast cancer cells.
DOI: 10.6084/m9.figshare.7931771
title: gVCF_HG02577

description: 1000 Genomes gVCF mapped to hs37d5 for HG02577. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7931774
title: gVCF_HG04182

description: 1000 Genomes gVCF mapped to hs37d5 for HG04182. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7931771.v1
title: gVCF_HG02577

description: 1000 Genomes gVCF mapped to hs37d5 for HG02577. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7931777.v2
title: MiR-195 regulates mitochondrial function by targeting mitofusin-2 in breast cancer cells

description: Mitochondrial dynamics is a highly dysregulated process in cancer. Apoptosis and mitochondrial fission are two concurrent events wherein increased mitochondrial fragmentation serves as a hallmark of apoptosis. We have shown earlier that miR-195 exerts pro-apoptotic effects in breast cancer cells. Herein, we have demonstrated miR-195 as a modulator of mitochondrial dynamics and function. Imaging experiments upon miR-195 treatment have shown that mitochondria undergo extensive fission. We validated mitofusin2 as a potential target of miR-195. This may provide a molecular explanation for the respiratory defects induced by miR-195 over-expression in breast cancer cells. Active, but not total, mitochondrial mass, was reduced with increasing levels of miR-195. We have further shown that miR-195 enhances mitochondrial SOD-2 expression but does not affect PINK1 levels in breast cancer cells. Collectively, we have revealed that miR-195 is a modulator of mitochondrial dynamics by targeting MFN2 thereby impairing mitochondrial function. Concomitantly, it enhances the scavenger of reactive oxygen species (SOD-2) to maintain moderate levels of oxidative stress. Our findings suggest a therapeutic potential of miR-195 in both ER-positive as well as ER-negative breast cancer cells.
DOI: 10.6084/m9.figshare.7931777.v1
title: MiR-195 regulates mitochondrial function by targeting mitofusin-2 in breast cancer cells.

description: Mitochondrial dynamics is a highly dysregulated process in cancer. Apoptosis and mitochondrial fission are two concurrent events wherein increased mitochondrial fragmentation serves as a hallmark of apoptosis. We have shown earlier that miR-195 exerts pro-apoptotic effects in breast cancer cells. Herein, we have demonstrated miR-195 as a modulator of mitochondrial dynamics and function. Imaging experiments upon miR-195 treatment have shown that mitochondria undergo extensive fission. We validated mitofusin2 as a potential target of miR-195. Which may provide a molecular explanation for the respiratory defects induced by miR-195 over-expression in breast cancer cells? Active, but not total, mitochondrial mass, was reduced with increasing levels of miR-195. We have further shown that miR-195 enhances mitochondrial SOD-2 expression but does not affect PINK1 levels in breast cancer cells. Collectively, we have revealed that miR-195 is a modulator of mitochondrial dynamics by targeting MFN2 thereby impairing mitochondrial function. Concomitantly, it enhances the scavenger of reactive oxygen species (SOD-2) to maintain moderate levels of oxidative stress. Our findings suggest a therapeutic potential of miR-195 in both ER-positive as well as ER-negative breast cancer cells.
DOI: 10.6084/m9.figshare.7931729
title: gVCF_HG02574

description: 1000 Genomes gVCF mapped to hs37d5 for HG02574. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7931735
title: Attributes of CelebA

description: Attributes for celebA from http://mmlab.ie.cuhk.edu.hk/projects/CelebA.html
DOI: 10.6084/m9.figshare.7931762
title: gVCF_NA19780

description: 1000 Genomes gVCF mapped to hs37d5 for NA19780. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7931762.v1
title: gVCF_NA19780

description: 1000 Genomes gVCF mapped to hs37d5 for NA19780. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7931735.v1
title: Attributes of CelebA

description: Attributes for celebA from http://mmlab.ie.cuhk.edu.hk/projects/CelebA.html
DOI: 10.6084/m9.figshare.7931723
title: gVCF_HG04180

description: 1000 Genomes gVCF mapped to hs37d5 for HG04180. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7931726
title: Background, sampling methods, and supplementary figures from Spawning by the European eel across 2000 km of the Sargasso Sea

description: It has been known for about a century that European eels have a unique life history that includes offshore spawning in the Sargasso Sea about 5000–7000 km away from their juvenile and adult habitats in Europe and Northern Africa. Recently hatched eel larvae were historically collected during Danish, German and American surveys in specific areas in the southern Sargasso Sea. During a 31-day period of March and April 2014, Danish and German research ships sampled for European eel larvae along 15 alternating transects of stations across the Sargasso Sea. The collection of recently hatched eel larvae (≤12 mm) from 70°W and eastward to 50°W showed that the European eel had been spawning across a 2000 km wide region of the North Atlantic Ocean. Historical collections made from 1921 to 2007 showed that small larvae had also previously been collected in this wide longitudinal zone, showing that the spatial extent of spawning has not diminished in recent decades, irrespective of the dramatic decline in recruitment. The use of such a wide spawning area may be related to variations in the onset of the silver eel spawning migration, individual differences in their long-term swimming ability, or aspects of larval drift.
DOI: 10.6084/m9.figshare.7931729.v1
title: gVCF_HG02574

description: 1000 Genomes gVCF mapped to hs37d5 for HG02574. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7931720
title: gVCF_NA19779

description: 1000 Genomes gVCF mapped to hs37d5 for NA19779. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7931723.v1
title: gVCF_HG04180

description: 1000 Genomes gVCF mapped to hs37d5 for HG04180. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7931726.v1
title: Background, sampling methods, and supplementary figures from Spawning by the European eel across 2000 km of the Sargasso Sea

description: It has been known for about a century that European eels have a unique life history that includes offshore spawning in the Sargasso Sea about 5000–7000 km away from their juvenile and adult habitats in Europe and Northern Africa. Recently hatched eel larvae were historically collected during Danish, German and American surveys in specific areas in the southern Sargasso Sea. During a 31-day period of March and April 2014, Danish and German research ships sampled for European eel larvae along 15 alternating transects of stations across the Sargasso Sea. The collection of recently hatched eel larvae (≤12 mm) from 70°W and eastward to 50°W showed that the European eel had been spawning across a 2000 km wide region of the North Atlantic Ocean. Historical collections made from 1921 to 2007 showed that small larvae had also previously been collected in this wide longitudinal zone, showing that the spatial extent of spawning has not diminished in recent decades, irrespective of the dramatic decline in recruitment. The use of such a wide spawning area may be related to variations in the onset of the silver eel spawning migration, individual differences in their long-term swimming ability, or aspects of larval drift.
DOI: 10.6084/m9.figshare.7931633
title: gVCF_NA19777

description: 1000 Genomes gVCF mapped to hs37d5 for NA19777. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7931693
title: CelebA resized

description: Resized and compressed CelebA dataset by http://mmlab.ie.cuhk.edu.hk/projects/CelebA.html
DOI: 10.6084/m9.figshare.7931720.v1
title: gVCF_NA19779

description: 1000 Genomes gVCF mapped to hs37d5 for NA19779. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7931633.v1
title: gVCF_NA19777

description: 1000 Genomes gVCF mapped to hs37d5 for NA19777. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7931627
title: gVCF_HG02573

description: 1000 Genomes gVCF mapped to hs37d5 for HG02573. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7931630
title: gVCF_HG04177

description: 1000 Genomes gVCF mapped to hs37d5 for HG04177. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7931597
title: gVCF_HG04176

description: 1000 Genomes gVCF mapped to hs37d5 for HG04176. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7931630.v1
title: gVCF_HG04177

description: 1000 Genomes gVCF mapped to hs37d5 for HG04177. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7931693.v1
title: CelebA resized

description: Resized and compressed CelebA dataset by http://mmlab.ie.cuhk.edu.hk/projects/CelebA.html
DOI: 10.6084/m9.figshare.7931567
title: gVCF_HG02568

description: 1000 Genomes gVCF mapped to hs37d5 for HG02568. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7931573
title: gVCF_NA19776

description: 1000 Genomes gVCF mapped to hs37d5 for NA19776. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7931627.v1
title: gVCF_HG02573

description: 1000 Genomes gVCF mapped to hs37d5 for HG02573. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7931567.v1
title: gVCF_HG02568

description: 1000 Genomes gVCF mapped to hs37d5 for HG02568. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7931573.v1
title: gVCF_NA19776

description: 1000 Genomes gVCF mapped to hs37d5 for NA19776. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7931597.v1
title: gVCF_HG04176

description: 1000 Genomes gVCF mapped to hs37d5 for HG04176. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7931555
title: L33-L103-1.fa

description: Illumina sequence data of seven strains
DOI: 10.6084/m9.figshare.7931555.v1
title: L33-L103-1.fa

description: Illumina sequence data of seven strains
DOI: 10.6084/m9.figshare.7931549
title: Prenatal diagnosis of closed spina bifida: multicenter case series and review of the literature

description: <b>Objective:</b> Closed spina bifida (CSB) is an abnormality of the posterior arch formation in which the defect is covered by the skin, without protrusion of nervous tissue. The prenatal diagnosis of CSB is very difficult, rarely diagnosed antenatally. <b>Methods:</b> We present a multicenter case series of six prenatal diagnosis of CSB using two-dimensional (2D) ultrasonography complemented with three-dimensional (3D) ultrasonography and magnetic resonance imaging (MRI). All cases of prenatal diagnosis of CSB were confirmed in the postnatal period/termination of pregnancy by both clinical and/or imaging diagnosis (ultrasonography and MRI). <b>Results:</b> 2D ultrasonography allowed the prenatal diagnosis of six cases. We observed two cases of subcutaneous lipomas, two cases of meningoceles, one case of fibrolipomas, and one case of false-positive CSB (meningomyelocele). 3D ultrasonography using rendering mode was important in one case of meningocele (case# 3). Three cases were delivered at term and one of them was submitted to corrective surgery. All these three newborns were discharged from the hospital well and without neurologic signs. Termination of pregnancy was performed in three cases. <b>Conclusion:</b> During prenatal evaluation, detailed ultrasonographic assessment of the entire spine with the identification of the position and morphology of the conus medullaris and absence of cranial signs of spinal dysraphism are the most valuable sonographic clues for the diagnostic of the CSB.
DOI: 10.6084/m9.figshare.7931534
title: gVCF_HG04173

description: 1000 Genomes gVCF mapped to hs37d5 for HG04173. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7931549.v1
title: Prenatal diagnosis of closed spina bifida: multicenter case series and review of the literature

description: <b>Objective:</b> Closed spina bifida (CSB) is an abnormality of the posterior arch formation in which the defect is covered by the skin, without protrusion of nervous tissue. The prenatal diagnosis of CSB is very difficult, rarely diagnosed antenatally. <b>Methods:</b> We present a multicenter case series of six prenatal diagnosis of CSB using two-dimensional (2D) ultrasonography complemented with three-dimensional (3D) ultrasonography and magnetic resonance imaging (MRI). All cases of prenatal diagnosis of CSB were confirmed in the postnatal period/termination of pregnancy by both clinical and/or imaging diagnosis (ultrasonography and MRI). <b>Results:</b> 2D ultrasonography allowed the prenatal diagnosis of six cases. We observed two cases of subcutaneous lipomas, two cases of meningoceles, one case of fibrolipomas, and one case of false-positive CSB (meningomyelocele). 3D ultrasonography using rendering mode was important in one case of meningocele (case# 3). Three cases were delivered at term and one of them was submitted to corrective surgery. All these three newborns were discharged from the hospital well and without neurologic signs. Termination of pregnancy was performed in three cases. <b>Conclusion:</b> During prenatal evaluation, detailed ultrasonographic assessment of the entire spine with the identification of the position and morphology of the conus medullaris and absence of cranial signs of spinal dysraphism are the most valuable sonographic clues for the diagnostic of the CSB.
DOI: 10.6084/m9.figshare.7931519
title: gVCF_NA19774

description: 1000 Genomes gVCF mapped to hs37d5 for NA19774. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7931519.v1
title: gVCF_NA19774

description: 1000 Genomes gVCF mapped to hs37d5 for NA19774. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7931507
title: gVCF_NA19773

description: 1000 Genomes gVCF mapped to hs37d5 for NA19773. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7931504
title: gVCF_HG04171

description: 1000 Genomes gVCF mapped to hs37d5 for HG04171. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7931504.v1
title: gVCF_HG04171

description: 1000 Genomes gVCF mapped to hs37d5 for HG04171. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7931492
title: gVCF_NA19771

description: 1000 Genomes gVCF mapped to hs37d5 for NA19771. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7931495
title: gVCF_HG02562

description: 1000 Genomes gVCF mapped to hs37d5 for HG02562. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7931489
title: lfw attributes

description: Attributes for LFW images obtained from http://www.cs.columbia.edu/CAVE/databases/pubfig/download/lfw_attributes.txt
DOI: 10.6084/m9.figshare.7931492.v1
title: gVCF_NA19771

description: 1000 Genomes gVCF mapped to hs37d5 for NA19771. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7931483
title: gVCF_HG04164

description: 1000 Genomes gVCF mapped to hs37d5 for HG04164. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7931483.v1
title: gVCF_HG04164

description: 1000 Genomes gVCF mapped to hs37d5 for HG04164. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.17866/rd.salford.7931465
title: Data relating to the ICA publication "Pupil dilation reveals changes in listening effort due to energetic and informational masking"

description: This repository contains the results and analysis script for the experiment described in:<br>J Woodcock, BM Fazenda, TJ Cox and WJ Davies (2019). "Pupil dilation reveals changes in listening effort due to energetic and informational masking". In Proceedings of 23rd International Congress on Acoustics, ICA.<br>Running the MATLAB script './analysis/readPupilData.m' will read and process the raw results files contained in './results/*.mat'. This will generate a .csv file with the processed results named 'ProcessedResults.csv'.<br>The R Markdown script './analysis/listening_effort_analysis.Rmd' will run the statistical analysis and generate the plots in the paper.<br>Running the MATLAB script './generate_stimuli/generateMixtures.m' will make the stimuli used in the experiment and store them as .mat files in './generate_stimuli/stimuli'. To run this script, the zip file containing all Harvard sentences produced in quiet condition should be downloaded from here and unzipped into './generate_stimuli/speech_wavs': https://doi.org/10.7488/ds/2482<br>
DOI: 10.6084/m9.figshare.7931468
title: gVCF_NA19770

description: 1000 Genomes gVCF mapped to hs37d5 for NA19770. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.17866/rd.salford.7931465.v1
title: Data relating to the ICA publication "Pupil dilation reveals changes in listening effort due to energetic and informational masking"

description: This repository contains the results and analysis script for the experiment described in:<br>J Woodcock, BM Fazenda, TJ Cox and WJ Davies (2019). "Pupil dilation reveals changes in listening effort due to energetic and informational masking". In Proceedings of 23rd International Congress on Acoustics, ICA.<br>Running the MATLAB script './analysis/readPupilData.m' will read and process the raw results files contained in './results/*.mat'. This will generate a .csv file with the processed results named 'ProcessedResults.csv'.<br>The R Markdown script './analysis/listening_effort_analysis.Rmd' will run the statistical analysis and generate the plots in the paper.<br>Running the MATLAB script './generate_stimuli/generateMixtures.m' will make the stimuli used in the experiment and store them as .mat files in './generate_stimuli/stimuli'. To run this script, the zip file containing all Harvard sentences produced in quiet condition should be downloaded from here and unzipped into './generate_stimuli/speech_wavs': https://doi.org/10.7488/ds/2482<br>
DOI: 10.6084/m9.figshare.7931453
title: File S5: Module functional annotation

description: Functional and pathway annotation for modules from the DREAM Disease Module Identification Challenge. Website: https://synapse.org/modulechallenge. Preprint: Choobdar, S., Ahsen, M.E., Crawford, J., et al. (2018). Open Community Challenge Reveals Molecular Network Modules with Key Roles in Diseases. bioRxiv 265553. https://www.biorxiv.org/content/early/2018/02/15/265553
DOI: 10.6084/m9.figshare.7931462
title: gVCF_HG02561

description: 1000 Genomes gVCF mapped to hs37d5 for HG02561. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7931468.v1
title: gVCF_NA19770

description: 1000 Genomes gVCF mapped to hs37d5 for NA19770. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7931447
title: gVCF_HG04162

description: 1000 Genomes gVCF mapped to hs37d5 for HG04162. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7931450
title: Community assembly of pond Mediterranean macrophytes

description: Iberian macrophyte assemblages and pond environmental characteristics
DOI: 10.6084/m9.figshare.7931438
title: gVCF_NA19764

description: 1000 Genomes gVCF mapped to hs37d5 for NA19764. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7931447.v1
title: gVCF_HG04162

description: 1000 Genomes gVCF mapped to hs37d5 for HG04162. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7931432
title: lfw-deepfunneled_reduced

description: Labelled Faces in the Wild dataset deep funnelled. Modified to align with attributes file provided by at http://www.cs.columbia.edu/CAVE/databases/pubfig/download/lfw_attributes.txt
DOI: 10.6084/m9.figshare.7931438.v1
title: gVCF_NA19764

description: 1000 Genomes gVCF mapped to hs37d5 for NA19764. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7931402
title: gVCF_HG02558

description: 1000 Genomes gVCF mapped to hs37d5 for HG02558. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7931405
title: Prova

description: Prova file
DOI: 10.6084/m9.figshare.7931396
title: Systematic review of the prognostic role of body mass index in amyotrophic lateral sclerosis

description: Studies have suggested that obesity is associated with better prognosis among individuals with various types of neurodegenerative diseases, and while some studies suggest that the same is true of amyotrophic lateral sclerosis (ALS), other works cast doubt on this conclusion. Therefore, we conducted a meta-analysis to systematically evaluate the role of body mass index in the prognosis of ALS. PubMed was systematically searched to identify eligible articles, and data on long-term survival were meta-analyzed in terms of hazard ratios (HR) with corresponding 95% confidence intervals (CI). Level of heterogeneity among studies and publication bias were estimated. A total of 17 studies with 9991 ALS patients were included in the review. Each increase of 1 kg/m<sup>2</sup> in body mass index was associated with significantly better long-term overall survival (HR 0.95, 95%CI 0.93–0.97; <i>p</i> p