cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.5281/zenodo.7602496
title: Dataset related to article "Implementing Pre-Therapeutic UGT1A1 Genotyping in Clinical Practice: A Real-Life Study"

description: This record contains raw data related to article “Implementing Pre-Therapeutic<em> UGT1A1</em> Genotyping in Clinical Practice: A Real-Life Study" Current guidelines recommend pre-therapeutic <em>UGT1A1</em> genotyping to guide irinotecan dosing, but the usefulness of this approach remains to be clarified. In 247 patients with advanced gastrointestinal cancers undergoing irinotecan-based chemotherapy, we prospectively performed <em>UGT1A1*28</em> genotyping and we analyzed the incidence of severe neutropenia according to genotype-guided dose reductions. Overall, 28 (11.3%) and 92 (37.2%) patients were homozygous or heterozygous <em>UGT1A1*28</em> carriers, respectively. Grade ≥ 3 neutropenia was reported in 39% of homozygous patients receiving an upfront dose reduction of irinotecan (median 40%, range 22-58%), in 20% of heterozygous or wild-type patients receiving full dose (OR<sub>vs*28/*28 genotype</sub> = 0.38; 95% CI: 0.14-1.03; <em>p</em> = 0.058), and in 15.3% of those receiving a reduced dose for clinical reasons (OR <sub>vs*28/*28 genotype</sub> = 0.28, 95% IC: 0.12-0.67; <em>p</em> = 0.004). Occurrence of severe neutropenia was inversely associated with dose reduction in <em>UGT1A1*28</em> homozygous carriers (OR<sub>x10 unit</sub> = 0.62, 95% CI: 0.27-1.40, <em>p</em> = 0.249) and <em>UGT1A1</em> heterozygous or wild-type patients (OR<sub>x10 unit</sub> = 0.87, 95% CI: 0.59-1.28, <em>p</em> = 0.478). Incidence of severe neutropenia was related to irinotecan doses and <em>UGT1A1</em> polymorphisms. Upfront irinotecan dose reductions do not reduce the burden of grade ≥ 3 neutropenia in <em>UGT1A1*28</em> homozygous carriers.
DOI: 10.5281/zenodo.7602495
title: Dataset related to article "Implementing Pre-Therapeutic UGT1A1 Genotyping in Clinical Practice: A Real-Life Study"

description: This record contains raw data related to article “Implementing Pre-Therapeutic<em> UGT1A1</em> Genotyping in Clinical Practice: A Real-Life Study" Current guidelines recommend pre-therapeutic <em>UGT1A1</em> genotyping to guide irinotecan dosing, but the usefulness of this approach remains to be clarified. In 247 patients with advanced gastrointestinal cancers undergoing irinotecan-based chemotherapy, we prospectively performed <em>UGT1A1*28</em> genotyping and we analyzed the incidence of severe neutropenia according to genotype-guided dose reductions. Overall, 28 (11.3%) and 92 (37.2%) patients were homozygous or heterozygous <em>UGT1A1*28</em> carriers, respectively. Grade ≥ 3 neutropenia was reported in 39% of homozygous patients receiving an upfront dose reduction of irinotecan (median 40%, range 22-58%), in 20% of heterozygous or wild-type patients receiving full dose (OR<sub>vs*28/*28 genotype</sub> = 0.38; 95% CI: 0.14-1.03; <em>p</em> = 0.058), and in 15.3% of those receiving a reduced dose for clinical reasons (OR <sub>vs*28/*28 genotype</sub> = 0.28, 95% IC: 0.12-0.67; <em>p</em> = 0.004). Occurrence of severe neutropenia was inversely associated with dose reduction in <em>UGT1A1*28</em> homozygous carriers (OR<sub>x10 unit</sub> = 0.62, 95% CI: 0.27-1.40, <em>p</em> = 0.249) and <em>UGT1A1</em> heterozygous or wild-type patients (OR<sub>x10 unit</sub> = 0.87, 95% CI: 0.59-1.28, <em>p</em> = 0.478). Incidence of severe neutropenia was related to irinotecan doses and <em>UGT1A1</em> polymorphisms. Upfront irinotecan dose reductions do not reduce the burden of grade ≥ 3 neutropenia in <em>UGT1A1*28</em> homozygous carriers.
DOI: 10.48567/m042-a023
title: Mount Siple Automatic Weather Station, 2003 Reader format three-hour observational data.
DOI: 10.48567/r6jm-2n36
title: Pegasus North Automatic Weather Station, 2003 Reader format three-hour observational data.
DOI: 10.48567/bw30-5d79
title: Pegasus South Automatic Weather Station, 2003 Reader format three-hour observational data.
DOI: 10.48567/e2av-9v23
title: Port Martin Automatic Weather Station, 2003 Reader format three-hour observational data.
DOI: 10.48567/8f8d-v557
title: Possession Island Automatic Weather Station, 2003 Reader format three-hour observational data.
DOI: 10.6084/m9.figshare.22005305
title: Playing at the School Table: Systematic Literature Review of Board, Tabletop and other Analogue Game-Based Learning Approaches

description: These are the different datasets used in the content analysis for the paper "Playing at the School Table: Systematic Literature Review of Board, Tabletop and other Analogue Game-Based Learning Approaches". This is a Systematic Literature Review aimed to map the existing literature on the potential of board, tabletop, or other analogue games in learning processes through the operationalization of the following specific objectives: (a) to explore the effectiveness of analogue GBL; (b) to analyze the adopted research designs and other methodological aspects of the existing approaches to analogue GBL; (c) to explore the main outcomes of analogue GBL, including learning outcomes, psychological, and cognitive outcomes; (d) to explore the used games and mechanics; and (e) to explore how research in the field of analogue GBL has been operationalizing inclusion and accessibility measures.
DOI: 10.48567/4ct7-6p19
title: Racer Rock Automatic Weather Station, 2003 Reader format three-hour observational data.
DOI: 10.25403/upresearchdata.21915387
title: Assessment of the impact of perception on the use of community parks

description: The datasets for a qualitative case study. The data was analysed to provide insights into physical and perceptual attributes which influences park visitation and use patterns. The analysis also provided insights on the impacts of the COVID-19 pandemic on the nature of people-park interactions. Data used for the analysis was obtained from direct observation, in-depth interviews, and responses provided to the survey questionnaires (N=42). The data collected were summarised and captured into Microsoft Excel spreadsheets then organized and processed. The researcher used hand coding and Microsoft Excel spreadsheet analysis to identify themes and patterns for analysis. These were done by examining qualitative data to find recurring themes and ideas then changed them into quantitative data for analysis.
DOI: 10.25403/upresearchdata.21915387.v1
title: Assessment of the impact of perception on the use of community parks

description: The datasets for a qualitative case study. The data was analysed to provide insights into physical and perceptual attributes which influences park visitation and use patterns. The analysis also provided insights on the impacts of the COVID-19 pandemic on the nature of people-park interactions. Data used for the analysis was obtained from direct observation, in-depth interviews, and responses provided to the survey questionnaires (N=42). The data collected were summarised and captured into Microsoft Excel spreadsheets then organized and processed. The researcher used hand coding and Microsoft Excel spreadsheet analysis to identify themes and patterns for analysis. These were done by examining qualitative data to find recurring themes and ideas then changed them into quantitative data for analysis.
DOI: 10.48567/0s92-y810
title: Relay Station Automatic Weather Station, 2003 Reader format three-hour observational data.
DOI: 10.48567/s0gf-c634
title: Schwerdtfeger Automatic Weather Station, 2003 Reader format three-hour observational data.
DOI: 10.48567/evbx-3r82
title: Siple Dome Automatic Weather Station, 2003 Reader format three-hour observational data.
DOI: 10.48567/vydg-s668
title: Sky Blu Automatic Weather Station, 2003 Reader format three-hour observational data.
DOI: 10.6084/m9.figshare.22005296
title: Supplementary material

description: The relevant raw data relate with the study of "Preservation of organic carbon associated with iron on continental shelves influenced by hydrodynamic processes"
DOI: 10.6084/m9.figshare.22005296.v1
title: Supplementary material

description: The relevant raw data relate with the study of "Preservation of organic carbon associated with iron on continental shelves influenced by hydrodynamic processes"
DOI: 10.48567/ahbb-8030
title: Theresa Automatic Weather Station, 2003 Reader format three-hour observational data.
DOI: 10.48567/yavv-9780
title: Uranus Glacier Automatic Weather Station, 2003 Reader format three-hour observational data.
DOI: 10.48567/z6z4-8e04
title: Whitlock Automatic Weather Station, 2003 Reader format three-hour observational data.
DOI: 10.48567/s7g4-2r74
title: Willie Field Automatic Weather Station, 2003 Reader format three-hour observational data.
DOI: 10.5281/zenodo.5614435
title: Fast-track regional sea level projections up to 2500 (PROTECT)

description: This NetCDF4 file contains regional sea-level change projections from 2020 to 2500 based on IPCC AR6 projections and a combination of linear extrapolations and scaling methods. Data are provided for scenarios SS1-2.6 and SSP2-4.5.
DOI: 10.48567/kv2y-1795
title: Windless Bight Automatic Weather Station, 2003 Reader format three-hour observational data.
DOI: 10.22008/fk2/brs3um/oakl1t
title: Schovsbo_Water_chemistrytablesummary.xlsx

description: Water Chemistyr data for Danish North Sea
DOI: 10.22008/fk2/brs3um
title: Replication Data for: Schovsbo, N.H., Hedegaard, K., Holmslykke, H.D., Kjøller, C., Kristensen, L., Thomsen, E., Esbensen, K.H., 2016. Formation water and produced water types in Danish oil and gas fields: Implications for enhanced oil recovery by “smart” water. Geological Survey of Denmark and Greenland Bulletin 35, 43–46."

description: Water Chemsitry and results from PCA analysis. Data from multiple source. Reference given in accompaning papaer
DOI: 10.48567/1rr5-ry92
title: Brianna Automatic Weather Station, 2003 quality-controlled observational data.
DOI: 10.48567/270q-x361
title: Cape Denison Automatic Weather Station, 2003 quality-controlled observational data.
DOI: 10.48567/ek8d-3c73
title: Clean Air Automatic Weather Station, 2003 quality-controlled observational data.
DOI: 10.48567/95q4-vf56
title: Laurie II Automatic Weather Station, 2003 quality-controlled observational data.
DOI: 10.48567/gp0e-1f08
title: Minna Bluff Automatic Weather Station, 2003 quality-controlled observational data.
DOI: 10.48567/8wbt-jx29
title: Possession Island Automatic Weather Station, 2003 quality-controlled observational data.
DOI: 10.3886/e147201
title: Code for: Tax Audits as Scarecrows Evidence from a Large-Scale Field Experiment

description: The canonical model of Allingham and Sandmo (1972) predicts that firms evade taxes by optimally trading off the costs and benefits of evasion. However, there is no direct evidence that firms react to audits in this way. We conducted a large-scale field experiment in collaboration with Uruguay’s tax authority to address this question. We sent letters to 20,440 small- and medium-sized firms that collectively paid more than 200 million U.S. dollars in taxes per year. Our letters provided exogenous yet nondeceptive signals about key inputs for their evasion decisions, such as audit probabilities and penalty rates. We measured the effect of these signals on their subsequent perceptions of the auditing process using survey data, as well as on the actual taxes paid using administrative data. We find that providing information about audits had a significant effect on tax compliance but in a manner that was inconsistent with Allingham and Sandmo (1972). Our findings are consistent with an alternative model of risk-as-feelings, in which messages about audits generate fear and induce probability neglect. According to this model, audits may deter tax evasion in the same way that scarecrows frighten off birds.
description: Small- and medium-sized firms in Uruguay.
DOI: 10.3886/e147201v1
title: Code for: Tax Audits as Scarecrows Evidence from a Large-Scale Field Experiment

description: The canonical model of Allingham and Sandmo (1972) predicts that firms evade taxes by optimally trading off the costs and benefits of evasion. However, there is no direct evidence that firms react to audits in this way. We conducted a large-scale field experiment in collaboration with Uruguay’s tax authority to address this question. We sent letters to 20,440 small- and medium-sized firms that collectively paid more than 200 million U.S. dollars in taxes per year. Our letters provided exogenous yet nondeceptive signals about key inputs for their evasion decisions, such as audit probabilities and penalty rates. We measured the effect of these signals on their subsequent perceptions of the auditing process using survey data, as well as on the actual taxes paid using administrative data. We find that providing information about audits had a significant effect on tax compliance but in a manner that was inconsistent with Allingham and Sandmo (1972). Our findings are consistent with an alternative model of risk-as-feelings, in which messages about audits generate fear and induce probability neglect. According to this model, audits may deter tax evasion in the same way that scarecrows frighten off birds.
description: Small- and medium-sized firms in Uruguay.
DOI: 10.48567/q5s2-sq61
title: Racer Rock Automatic Weather Station, 2003 quality-controlled observational data.
DOI: 10.3886/e182963
title: Data and Code for: SOEs and Soft Incentive Constraints in State Bank Lending

description: We study how Chinese state bank managers' lending incentives impact lending to state-owned enterprises. We show lending quantity increases and quality decreases at month's end, indicating monthly lending targets that decrease lending standards. Increased quantity comes from both SOEs and private lending, whereas decreased quality is from only SOEs, which continue to receive loans even after prior defaults (particularly at month's end). We suggest that SOE lending may thus be beneficial for state bank managers, who lend to delinquent state enterprises to meet targets, which in turn may exacerbate SOEs' soft budget constraints.
DOI: 10.3886/e182963v1
title: Data and Code for: SOEs and Soft Incentive Constraints in State Bank Lending

description: We study how Chinese state bank managers' lending incentives impact lending to state-owned enterprises. We show lending quantity increases and quality decreases at month's end, indicating monthly lending targets that decrease lending standards. Increased quantity comes from both SOEs and private lending, whereas decreased quality is from only SOEs, which continue to receive loans even after prior defaults (particularly at month's end). We suggest that SOE lending may thus be beneficial for state bank managers, who lend to delinquent state enterprises to meet targets, which in turn may exacerbate SOEs' soft budget constraints.
DOI: 10.22008/fk2/igtvxi/syuitx
title: Schovsbo_East_denmark18012019_brine_PCA_results.xlsx

description: Water chemistry data input to PCA model.
DOI: 10.22008/fk2/igtvxi
title: Replication Data for: Holmslykke, H.D., Schovsbo, N.H., Kristensen, L., Weibel, R., Nielsen, LH., 2019. Characteris-ing brines in deep Mesozoic sandstone reservoirs, Denmark. Geological Survey of Denmark and Greenland Bulletin 43, e2019430104, 1–5.

description: Water chemistry data input to PCA model.
DOI: 10.25403/upresearchdata.21941657
title: Difference between theoretical and practical Nexus implementation

description: A summarised dataset of the Nexus concepts (roles, events, and arefacts) which were changed from the theoretical framework when practically implemented in a FinTech enterprise; giving reasons for these changes based on the case study findings. The concepts which were not changed or not implemented are also listed, giving a complete view of all the Nexus concepts and how/if they were adapted. The table highlights the insights obtained from this case study when practically implementing Nexus at the enterprise, showing any changes and giving reasons for such changes.
DOI: 10.25403/upresearchdata.21941657.v1
title: Difference between theoretical and practical Nexus implementation

description: A summarised dataset of the Nexus concepts (roles, events, and arefacts) which were changed from the theoretical framework when practically implemented in a FinTech enterprise; giving reasons for these changes based on the case study findings. The concepts which were not changed or not implemented are also listed, giving a complete view of all the Nexus concepts and how/if they were adapted. The table highlights the insights obtained from this case study when practically implementing Nexus at the enterprise, showing any changes and giving reasons for such changes.
DOI: 10.3886/e147621
title: Data and Code for "Exploring Residual Profit Allocation"

description: Residual profit allocation (RPA) schemes have rapidly come to prominence in discus- sions of international tax reform, but with almost nothing known about their economic impact. These schemes tax multinationals by allocating their ‘routine’ profits to coun- tries in which their activities take place and sharing their remaining ‘residual’ profit across countries—including perhaps ‘destination’ countries, in which they may have no physical presence but only a digital one—on some formulaic basis. These are fundamen- tal departures from century-old norms. This paper explores the implications, conceptual and empirical, of moving to some form of RPA. Residual profits are estimated to be substantial, concentrated in relatively few multinationals that are relatively heavy in intangible assets, and with by far the largest share accruing to those headquartered in the United States. The impact on tax revenue of adopting a destination-based RPA is substantial for many countries; while adverse for investment hubs, it appears, strik- ingly, to be beneficial for developing countries. The directional impact on investment is specific to both countries and multinationals, and aggregate production efficiency is unlikely to increase unless routine profits are lightly taxed.
DOI: 10.3886/e147621v1
title: Data and Code for "Exploring Residual Profit Allocation"

description: Residual profit allocation (RPA) schemes have rapidly come to prominence in discus- sions of international tax reform, but with almost nothing known about their economic impact. These schemes tax multinationals by allocating their ‘routine’ profits to coun- tries in which their activities take place and sharing their remaining ‘residual’ profit across countries—including perhaps ‘destination’ countries, in which they may have no physical presence but only a digital one—on some formulaic basis. These are fundamen- tal departures from century-old norms. This paper explores the implications, conceptual and empirical, of moving to some form of RPA. Residual profits are estimated to be substantial, concentrated in relatively few multinationals that are relatively heavy in intangible assets, and with by far the largest share accruing to those headquartered in the United States. The impact on tax revenue of adopting a destination-based RPA is substantial for many countries; while adverse for investment hubs, it appears, strik- ingly, to be beneficial for developing countries. The directional impact on investment is specific to both countries and multinationals, and aggregate production efficiency is unlikely to increase unless routine profits are lightly taxed.
DOI: 10.17632/px4dzwwh2d.4
title: Liu and Luo LGM ATL Water Mass

description: This data file contains a comprehensive compilation of coretop and LGM wtCaCO3%, eNd, d13C and 231Pa/230Th for the Atlantic Ocean. It serves as supplementary Table S1 for our manuscript entitled 'Reorganization of Atlantic deep water masses during the Last Glacial Maximum' by Xiaoqing Liu, Yiming Luo, Jimin Yu, Jörg Lippold, Bernard P. Boudreau and Roger Francois.
DOI: 10.17632/4rjb88t4mc.2
title: Anthropometric indicators /depressive symtoms in peruvian population

description: This .do file resumes commands for the anthropometric indicators and depressive symptoms analysis.
DOI: 10.17632/czzb4jb8ss.1
title: SARS-CoV-2 restructures host chromatin architecture

description: Some viruses restructure host chromatin, influencing gene expression, with implications for disease outcome. Whether this occurs for SARS-CoV-2, the virus causing COVID-19, is largely unknown. Here, we characterized the 3D genome and epigenome of human cells after SARS-CoV-2 infection, finding widespread host chromatin restructuring that features widespread A compartmental weakening, A-B mixing, reduced intra-TAD contacts and decreased H3K27ac euchromatin modification levels. Such changes were not found following common-cold virus HCoV-OC43 infection. Intriguingly, the cohesin complex was significantly depleted from intra-TAD regions, indicating that SARS-CoV-2 disrupts cohesin loop extrusion. These altered 3D genome/epigenome structures correlated with transcriptional suppression of interferon response genes by the virus, while increased H3K4me3 was found in the promoters of pro-inflammatory genes highly induced during severe COVID-19. These findings show that SARS-CoV-2 acutely rewires host chromatin, facilitating future studies of the long-term epigenomic impacts of its infection. This work is to be published in Nature microbiology (Wang et al., 2023).
DOI: 10.17632/jgsv9xgwk8.1
title: The perceptual categorization of multidimensional stimuli is hierarchically organized

description: As we interact with our surroundings, we encounter the same or similar objects from different perspectives and are compelled to generalize. For example, we recognize dog barks as a distinct class of sound, despite the variety of individual barks. While we have some understanding of how generalization is done along a single stimulus dimension, such as frequency or color, natural stimuli are identifiable by a combination of dimensions. To understand perception, measuring the interaction across stimulus dimensions is essential. For example, when identifying a sound, does our brain focus on a specific dimension or a combination, such as its frequency and duration? Furthermore, does the relative relevance of each dimension reflect its contribution to the natural sensory environment? Using a 2-dimension discrimination task for mice we tested untrained generalization across several pairs of auditory dimensions. We uncovered a perceptual hierarchy over the tested dimensions that was dominated by the sound’s spectral composition.
DOI: 10.17632/6x5rhvs32y.1
title: Survival based on BRAF detection in combined tissue and liquid biopsy in melanoma

description: Liquid biopsy provides a suitable option with progressively improved sensitivity and specificity to complement or to substitute the information obtained by regular biopsy. Extracellular vesicles (EVs) are emerging as powerful tools for providing information about the tumor and its microenvironment. The present study compares the information provided by tissue and EV-based liquid biopsy for the determination of BRAF status  (BRAFV600E mutation or BRAF wild type) and analyzes their prognostic capacity. This data set suggests that combination of information from liquid and tissue biopsy regarding BRAF status in melanoma patients identifies the presence of BRAF mutation as a negative prognostic factor for short term survival in melanoma patients whereas individual analyses fail to stratify patients according their survival.
DOI: 10.17632/mbsx5b8vhm.1
title: Pleurotus pulmonarius LBM 105 de novo whole-genome assembly

description: Here we present the de novo whole-genome assembly of the White-rot fungus Pleurotus pulmonarius LBM 105. The genome was assembled and annotated using the CLC workbench.
DOI: 10.17632/gccpg29vmg.1
title: Supplemental Material: A Comparison of Family Physician and Dermatologist Topical Corticosteroid Prescriptions: A Population-Based Cross-Sectional Study

description: Supplemental Material: A Comparison of Family Physician and Dermatologist Topical Corticosteroid Prescriptions: A Population-Based Cross-Sectional Study