cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.28082687.v2
title: Metadata from - Impact of metformin on HBV replication: no evidence of suppression in vitro

description: These are the metadata associated with the article 'Impact of metformin on HBV replication: no evidence of suppression in vitro' from Hawkins et al,<br><b>Background</b>: Chronic Hepatitis B (CHB) infection has been increasingly associated with various metabolic syndromes, with a potential for exacerbation of liver disease progression. There is some evidence that metformin, a widely used anti-diabetic drug, may reduce HCC incidence in both people living with Hepatitis B Virus (HBV), with little to no evidence of impact on the virus itself <i>in vivo</i>. In contrast, previous <i>in vitro</i> studies suggest metformin may have a direct impact on HBV replication, although the mechanism remains unclear.<b>Objectives</b>: We aimed to investigate the impact of metformin on HBV replication <i>in vitro</i>.<b>Study</b> <b>design</b>: Hepatocyte cell lines constitutively expressing HBV (HepAD38) were treated once or thrice with escalating doses of metformin, using lamivudine and water as controls. We monitored cellular cytotoxicity as well as HBV biomarkers (HBeAg, HBsAg, HBV DNA and RNA) throughout the assay.<b>Results</b>: We did not observe any impact of metformin on HBV replication after a single dose or repeat treatments.<b>Conclusions</b>: In HepAD38 cells, HBV is not susceptible to metformin treatment. This contrasts with prior <i>in vitro</i> data but is in line with clinical evidence that suggests metformin acts through an influence on liver disease progression rather than a direct antiviral impact on HBV itself.<br>
DOI: 10.6084/m9.figshare.28737671.v4
title: <b>Digital Divide and the Spiritual and Cultural Consumption Levels of Urban and Rural Residents in China: A Multidimensional ICT Perspective</b>

description: The paper explores the path dependency of urban and rural residents' spiritual and cultural consumption levels (URRSCCL) across different regions in China and examines the impact of multidimensional information and communication technology (ICT) on URRSCCL. This is based on panel data from 2013 to 2022.
DOI: 10.6084/m9.figshare.4036584.v1
title: Megalosauripus transjuranicus and other large tridactyl tracks from the Ajoie district (NW Switzerland). 3D meshes

description: 3D models of the large tridactyl tracks including the type specimens of <i>Megalosauripus transjurani.</i> All the collected and/or casted specimens, are stored and accessible at the PALA16 collections (Office de la Culture, 2900, Porrentruy, Switzerland) and will be transferred to the JURASSICA Muséum (Route de Fontenais 21, 2900, Porrentruy, Switzerland) at the end of 2018.Files are labelled accordingly the track IDs. All photogrammetric models were generated with a Canon EOS 70D thought Agisoft Photoscan Pro (v. 1.2.5 and 1.2.6); number of photos used, accuracy and resolution of each models are in the associated pdf. "laser" in the file name indicates tracks that were laser-scanned in 2011 with a FARO Platinum Scanarm 3.0 m. Processing information in the associated pdf. Citation for this article: Razzolini N.L., Belvedere M., Marty D., Paratte G., Lovis C., Cattin M., and Meyer C.A. <b>in press </b>(2017). <i>Megalosauripus transjuranicus</i> ichnosp. nov. A new Late Jurassic theropod ichnotaxon from NW Switzerland and implications for tridactyl dinosaur ichnology and ichnotaxomy. PLoS ONE.
DOI: 10.6084/m9.figshare.6833789.v1
title: Supplementary Material for: CXCL12 in Patients with Chronic Kidney Disease and Healthy Controls: Relationships to Ambulatory 24-Hour Blood Pressure and Echocardiographic Measures

description: <b><i>Background/Aims:</i></b> Chronic kidney disease is a pro-inflammatory condition where the interplay between different regulatory pathways and immune cells mediates an unfavorable remodeling of the vascular wall and myocardial hypertrophy. These mechanisms include the action of CXCL12. The aim of this study is to evaluate the association between serum CXCL12 with left ventricular hypertrophy (LVH) and blood pressure control in chronic kidney disease (CKD) patients. <b><i>Methods:</i></b> This single-center observational study involved 90 stable CKD stage 1–5 patients (including 33 renal transplant recipients) and 25 healthy age- and sex-matched control subjects. CXCL12 was quantified by ELISA. 24-h ambulatory blood pressure monitoring was performed in 90 patients and 25 healthy controls. Left ventricular mass index (LVMI) was calculated based on the transthoracic echocardiography measurements in 27 patients out of the CKD population and in the whole control group. <b><i>Results:</i></b> CXCL12 correlated significantly with LVMI by multivariate regression analysis (coefficient <i>B</i> = 0.33, <i>p</i> = 0.02) together with age (<i>B</i> = 0.30, <i>p</i> = 0.03) and gender (<i>B</i> = 0.41, <i>p</i> = 0.003). A positive correlation was observed between CXCL12 and average 24-h systolic blood pressure (SBP) (rho = 0.35, <i>p</i> = 0.001), daytime SBP (rho = 0.35, <i>p</i> = 0.001), and nocturnal SBP (rho = 0.30, <i>p</i> = 0.002). Nocturnal hypertension was frequent (46% of CKD patients). <b><i>Conclusions:</i></b> The results of our study point towards a link between CXCL12 and LVH as well as blood pressure control among patients with CKD, supporting the thesis that CXCL12 may be regarded as a new potential uremic toxin.
DOI: 10.6084/m9.figshare.5124586.v1
title: Supplementary Material for: O-Methylated Metabolite of 7,8-Dihydroxyflavone Activates TrkB Receptor and Displays Antidepressant Activity

description: 7,8-Dihydroxyflavone (7,8-DHF) acts as a TrkB receptor-specific agonist. It mimics the physiological actions of brain-derived neurotrophic factor (BDNF) and demonstrates remarkable therapeutic efficacy in animal models of various neurological diseases. Nonetheless, its in vivo pharmacokinetic profiles and metabolism remain unclear. Here we report that 7,8-DHF and its O-methylated metabolites distribute in mouse brain after oral administration. Both hydroxy groups can be mono-methylated, and the mono-methylated metabolites activate TrkB in vitro and in vivo. Blocking methylation, using COMT inhibitors, diminishes the agonistic effect of TrkB activation by 7,8-DHF or 4′-dimethylamino-7,8-DHF, supporting the contribution of the methylated metabolite to TrkB activation in mouse brain. Moreover, we have synthesized several methylated metabolite derivatives, and they also potently activate the TrkB receptor and reduce immobility in both forced swim test and tail suspension test, indicating that these methylated metabolites may possess antidepressant activity. Hence, our data demonstrate that 7,8-DHF is orally bioavailable and can penetrate the brain-blood barrier. The O-methylated metabolites are implicated in TrkB receptor activation in the brain.
DOI: 10.6084/m9.figshare.14447097.v1
title: Meshes for Morphonet

description: Morphonet is an interactive browser based platform for visualizing 3D, 3D+t segmented datasets. It provides interaction tools to explore the structure, dynamics and variability of biological shapes and quantitative information associated with them on a cellular level. You can access Morphonet at:<br>https://morphonet.org/<br>Research paper on Morphonet: https://www.nature.com/articles/s41467-019-10668-1<br>In this folder you will find the 3D meshes for uploading to Morphonet for 3D visualization of segmented floral meristem images. These meshes have been derived from the four sample segmented stacks provided in this repository (under the folder "Original stacks and segmented data").<br>In this repository, you may also find the accuracy results (volume-averaged Jaccard Index values) for each segmentation pipeline (Plantseg, Unet+Watershed, Cellpose, MRCNN+Watershed, MARS) in the folder "Accuracy results".<br><br>You can upload the meshes along with accuracy results on Morphonet to have an interactive view of the accuracy metric super-posed on the cells as color maps. You can slice through the mesh along XYZ planes and study the accuracy values in different layers of cells.<br><br>For more details on the mesh+data upload process and the Morphonet based 3D visualization technique go to:https://mosaic.gitlabpages.inria.fr/publications/seg_compare/<br>
DOI: 10.6084/m9.figshare.14555973.v1
title: Data derived from the analysis

description: Data derived from the statistical analysis is presented here.
DOI: 10.6084/m9.figshare.19241559.v3
title: Raw fastq reads (Read_1) of F2 individuals (susceptible pool n=10) derived by crossing C. moschata (Nigerian Local X Butterbush)

description: Raw fastq reads (Read 1) of PRSV susceptible F2 individual (n=10) derived by crossing C. moschata (Nigerian Local X Butterbush).
DOI: 10.6084/m9.figshare.28648574.v1
title: <b>Drivers</b><b> </b><b>of Aboveground Biomass in </b><b><i>Quercus wutaishanica</i></b><b> </b><b>Mayr Forests</b><b> </b><b>Based on Random Forest and Structural Equation Modeling: A Cross-scale Analysis</b>

description: The effects of abiotic factors, encompassing climatic conditions and soil properties, and biotic factors that involve grass coverage and forest age, and disturbances on the AGB of <i>Q. wutaishanica</i> forests across various scales in China
DOI: 10.6084/m9.figshare.13669853.v1
title: MSFragger-Glycan-Database-from-MSFragger-Glyco-paper.xlsx

description: N- and O-glycan databases of MSFragger-Glyco
DOI: 10.6084/m9.figshare.17762696.v3
title: AACA-D-21-00020

description: Two datasets were used to verify the idea of this paper as shown in Figure 3. The 3D vector field data is the wind data set in MATLAB, which is the wind field data over America with data size 35x41x15 (longitude-latitude-elevation). The 2D vector field data used in this experiment are the global average monthly wind field data published by the National Oceanic and Atmospheric Administration for the period 1871-2012. The data is organized into temporal and spatial data (longitude-latitude-elevation-time), the data size is 180x91x24x1704. The bottom section (elevation 0) of the wind field in May 1873 is selected as the two-dimensional vector field data with size 180x91.To simulate different levels of data security, here we used three perturbation schemes and four rotation angle schemes. The rotation axis is set to stationary to make the results comparable. The three perturbation vector schemes are (0.1σ,0.3σ), (0.3σ,0.5σ) and (0.5σ,0.7σ); the four rotation angle schemes are (4,6), (9,11), (24,26) and (44,46). The results were saved as out-2D/3D-perturbation scheme ID-angle scheme ID (ID starting from 0). For example, out-3D1-2 means the declassification result of 3D wind field with perturbation vector scheme (0.3σ,0.5σ) and angle scheme (24,26).
DOI: 10.6084/m9.figshare.28789718.v2
title: Source data of Neoantigens combined with in situ cancer vaccination induce personalized immunity and reshape the tumor microenvironment

description: Neoantigen (nAg) vaccines can induce anti-tumor specific immunity, and tumor killing promotes further antigen diffusion, which is expected to improve prognosis. However, the mutation of cancer cells under the selective pressure of vaccines and the immunosuppressive tumor microenvironment make the therapeutic effect unsatisfactory. Here, we develop a nanovaccine (nAg-MRDE/Mn) that can deliver nAg and induce in situ cancer vaccination to synergistically promote a personalized immune response, enhance antigen diffusion, and improve the microenvironment by modulating immunosuppressive cells and activating the innate immune response. Experiments show that neoantigens are presented by dendritic cells and expressed by T cells, which cooperate with in situ vaccination to stimulate specific immunity. Cells involved in immunosuppression, such as M2 macrophages and regulatory T cells, are down-regulated, while M1 macrophages and natural killer cells are increased. In addition, the hydrogel loaded with chemokines and nAg-MRDE/Mn inhibits postoperative tumor recurrence, and the combination of nAg-MRDE/Mn and αPD-1 improves the therapeutic effect of αPD-1. This study validates the clinical potential of this strategy and provides ideas for improving neoantigen vaccines.
DOI: 10.6084/m9.figshare.12482639.v1
title: Supplementary Material for: Etiology of Atrial Functional Mitral Regurgitation: Insights from Transthoracic Echocardiography in 159 Consecutive Patients with Atrial Fibrillation and Preserved Left Ventricular Ejection Fraction

description: <b><i>Background:</i></b> Left atrial (LA) dilatation in patients with atrial fibrillation (AF) can induce functional mitral regurgitation (MR) despite a preserved left ventricular ejection fraction (LVEF). The purpose of this study was to investigate the etiology of this functional MR. <b><i>Methods:</i></b> We retrospectively examined clinical and echocardiographic data from 5,202 consecutive cases that underwent transthoracic echocardiography. AF appeared in 544 patients, and we selected 159 with AF and LVEF ≥50% after excluding patients with other underlying heart diseases. <b><i>Results:</i></b> Significant (moderate or greater) degrees of functional MR were seen in 13 (8.2%) patients and were more frequently seen in patients with an AF duration of &gt;10 years than in others (27 vs. 4%, <i>p</i> = 0.0057). Multiple regression analysis revealed that both the LA dimension index and the left ventricular (LV) systolic dimension index were independent determinants of the MR grading. Among the mitral morphologic parameters, the mitral annular (MA) dimension index and the hamstringing phenomenon of the posterior mitral leaflet were independent determinants of MR grading. Significant MR was not seen in patients without LA dilatations, but it occurred in 14% of patients with LA dilatation alone and in 55% with both LA and LV dilatations; the MA dimension index increased in this order. <b><i>Conclusions:</i></b> The grading of functional MR occurring in patients with AF and preserved LVEF depends on both the LA dimension and the LV systolic dimension. The MR grading also depends on both the MA dilatation and the hamstringing phenomenon of the posterior mitral leaflet.
DOI: 10.6084/m9.figshare.27906300.v1
title: The release of Pitaya genomes of<i> </i><i>H. polyrhizus (</i>Cultivar. ShuangSe (Gapfree),Cultivar. DaHong<i>) and </i><i>H. stenopterus (</i>Wild variety. Honghuaqinglong<i>)</i>

description: Pitaya is an important perennial herbaceous fruit tree belongs to <i>Hylocereus</i> or <i>Selenicereus </i>and well-known of its betalain accumulation. Here, we reported a telomere-to-telomere (T2T) genome of <i>H. </i><i>polyrhizus</i>cultivar ‘Shuangse No.1’, 'Dahong' .
DOI: 10.6084/m9.figshare.28038662.v1
title: Supplement data and tables

description: Supplemental data and tables for "Proteomic and serologic assessments of responses to mRNA-1273 and BNT162b2 vaccines in human recipient sera".
DOI: 10.6084/m9.figshare.28509578.v1
title: Interview recordings with Vietnamese practitioners about Circular Economy

description: These practitioners participated in workshops and were invited to answer interview questions by writing their responses themselves.
DOI: 10.15468/dl.5anmtt
title: Occurrence Download

description: A dataset containing 597 species occurrences available in GBIF matching the query:
{
 "and" : [
 "HasGeospatialIssue is false",
 "HasCoordinate is true",
 "OccurrenceStatus is Present",
 {
 "not" : {
 "BasisOfRecord" : [
 "is one of (Observation, Human Observation, Machine Observation, Living Specimen)"
 ]
 }
 },
 "TaxonKey is Hedya salicella (Linnaeus, 1758)"
 ]
}

 The dataset includes 597 records from 38 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0009439-250426092105405/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.6084/m9.figshare.12783944.v1
title: Data sets

description: All raw data sets
DOI: 10.6084/m9.figshare.5125621.v1
title: Supplementary Material for: The Effectiveness of Cognitive Remediation Therapy in Patients with a Severe or Enduring Eating Disorder: A Randomized Controlled Trial

description: <b><i>Background:</i></b> Individuals with eating disorders show deficits in neuropsychological functioning which might preexist and underlie the etiology of the eating disorders and influence relapse. Deficits in cognitive flexibility, i.e. set-shifting and central coherence, might perpetuate the symptoms. Cognitive remediation therapy (CRT) was developed to improve cognitive flexibility, thereby increasing the likelihood of improved outcome. The focus of CRT is on <i>how</i> patients think, rather than on <i>what</i> patients think. The present study investigated the effectiveness of CRT for patients with a severe or enduring eating disorder by means of a randomized controlled trial comparing intensive treatment as usual (TAU) to CRT plus TAU. <b><i>Methods:</i></b> Eighty-two patients were randomly assigned to CRT plus TAU (n = 41) or TAU alone (n = 41). Outcome measures were set-shifting, central coherence, eating disorder and general psychopathology, motivation, quality of life and self-esteem. Assessments were performed at baseline (n = 82) and after 6 weeks (T1; n = 75) and 6 months (T2; n = 67). Data were analyzed by means of linear mixed model analyses. <b><i>Results:</i></b> Patients who received CRT in addition to TAU improved significantly more with regard to eating disorder-related quality of life at the end of treatment (T1) and eating disorder psychopathology at follow-up (T2), compared to those who received TAU only. Moreover, moderator analyses revealed that patients with poor baseline set-shifting abilities benefited more from CRT than patients with no deficits in set-shifting abilities at baseline; the quality of life of the former group was higher than that of the latter at follow-up. <b><i>Conclusions:</i></b> CRT seems to be promising in enhancing the effectiveness of concurrent treatment.
DOI: 10.15482/usda.adc/1529220
title: USDA Agricultural Research Service- Patented Crop Production and Crop Protection Technologies

description: Recent USDA/ARS patented technologies on crop production and protection that are available for licensing are described, including summary, contact, benefits, and applications. Updated June 2018.
DOI: 10.6084/m9.figshare.21593271.v1
title: Supplementary Material for: Long-Term Retention of Young Adult Study Participants with Youth-Onset Type 2 Diabetes: Results from the TODAY2 Study

description: Introduction: The Treatment Options for type 2 Diabetes in Adolescents and Youth (TODAY) trial examined the effects of three treatment arms in a group of racially and ethnically diverse adolescents and youth with type 2 diabetes mellitus. TODAY2 was an observational follow-up study reporting outcomes and complications in these participants after having diabetes for approximately 13 years. Participant retention was essential to fulfill this objective. This report describes motivations and problems participants self-reported related to continuing in this study. Methods: The TODAY2 retention survey was administered to participants, mean age 27 years, 36% non-Hispanic Black, 18% non-Hispanic white, 39% Hispanic, 52% public and 35% private healthcare coverage, who completed the last study visit (63.8% of original TODAY cohort). The survey listed potential benefits and barriers to staying in the trial. Participants indicated agreement or disagreement with each statement using a four point Likert-type scale. Results: More than 93% of survey responders agreed with benefits listed for staying in TODAY2. The most cited reason for staying in the study was related to the strong relationship that participants had with study staff. The common barriers to attending trial visits were: tending to other medical problems, fear of disappointing study staff, and school/work scheduling conflicts. Participants with public healthcare coverage were more likely to endorse benefits related to diabetes care (e.g. getting latest test results, staying motivated to care for my diabetes) and monetary compensation, whereas participants with poor glycemic control cited that a barrier to attending study visits was “fear of disappointing” study staff. Discussion/Conclusion: In a racially and ethnically diverse population of youth-onset type 2 diabetes, benefits and barriers associated with long-term retention are described. These findings can be used to help inform future retention strategies for young adults in clinical trials.
DOI: 10.6084/m9.figshare.20220057.v1
title: SciSciNet_Affiliations

description: SciSciNet_Affiliations
DOI: 10.6084/m9.figshare.21981293.v3
title: Supplementary Material for: A Patient with Transverse Colon Cancer Complicated by Cowden Syndrome Administered FOLFOXIRI + Bevacizumab Therapy

description: Cowden syndrome is characterized by several clinical features related to tumorous lesions primarily consisting of systemic hamartomas. The mutation of a tumor suppressor gene, the <i>PTEN</i> gene, is etiologically involved. As gastrointestinal lesions, polyps of all digestive tracts involving the esophagus to rectum develop. In patients with Cowden syndrome, the risk of colorectal cancer may increase. However, the characteristics of colorectal cancer in these patients remain to be clarified and sufficient findings regarding chemotherapy have not been obtained. A 39-year-old man was treated with a colonic stent for colitis obstructive due to circumferential transverse colon carcinoma. After decompression, elective extended laparoscopic right hemicolectomy was performed. Preoperative systemic detailed examination revealed characteristic dermal/mucosal findings, polyposis of the upper digestive tract, and a thyroid tumor. On <i>PTEN</i> gene sequencing, a mutation was detected at codon 130 of exon 5, leading to a diagnosis of Cowden syndrome. Postoperative adjuvant chemotherapy was performed for 6 months, but recurrent peritoneal dissemination was observed 1 month after its completion. FOLFOXIRI + bevacizumab therapy was started. Transiently, a partial response was achieved in peritoneally disseminated nodes according to the RECIST. There was no increase in the volume of cancerous ascites. However, an increase in the volume of ascites and local relapse were noted at the completion of the tenth course. The regimen was switched to FOLFIRI + panitumumab, but peritoneal dissemination exacerbated and the patient died 18 months after surgery.
DOI: 10.6084/m9.figshare.14152313.v2
title: S255 Herschel column density map

description: The column density map obtained from the fit to the Herschel 160-500 micron data.
DOI: 10.6084/m9.figshare.28730096.v1
title: Data for the plots in Figures 1–4.

description: Water scarcity impacts over 2.2 billion people globally, especially in underdeveloped, landlocked, or off-grid regions. Passive sorbent-based atmospheric water harvesting offers a promising solution by converting ubiquitous atmospheric moisture into liquid water. However, current approaches are limited by several milliliters of daily water production, unsafe lithium (Li+) ion release, or inefficiency in low relative humidity (RH) conditions. We report an atmospheric water harvesting window (AWHW) featuring a vertical origami hydrogel panel and a window-like solar still. This passive, meter-scale device was tested in Death Valley, producing 57.0 to 161.5 ml of water daily across an RH range of 21% to 88%. It has a lifespan of at least one year and ensures safe water with Li+ concentrations below 0.06 ppm. Our AWHW sets a new benchmark in daily water production and climate adaptability, representing an advancement toward practical, scalable, safe, and sustainable decentralized water solutions for the most water-stressed regions.