cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.12056592.v1
title: Efficacy of Leuprorelide acetate (Eligard®) in daily practice in Brazil: a retrospective study with depot formulations in patients with prostate cancer

description: ABSTRACT Introduction: Androgen deprivation therapy (ADT) is the mainstay of therapy for advanced prostate cancer. Studies addressing the efficacy of different depot formulations of long acting luteinizing hormone releasing hormone agonists in the Brazilian population are lacking. We aimed to compare the efficacy of three schedules of leuprolide acetate in lowering PSA in a real world population. Materials and Methods: We reviewed the medical records of patients with prostate cancer seen at our institution between January 2007 and July 2018. We analyzed patients treated with long-acting leuprolide acetate and grouped these patients into three strata according to the administration of ADT every 1, 3 or 6 months. The primary outcome was the serum prostate specific antigen (PSA) levels at 6 and 12 months after treatment initiation. We used Friedman test to compare the distribution of PSA levels at baseline and at 6 and 12 months within each treatment stratum. We considered two-sided P values &lt;0.05 as statistically significant. We analyzed toxicity descriptively. Results: We analyzed a total of 932 patients, with a median age of 72 years and a median time since diagnosis of prostate cancer of 8.5 months. ADT was administered monthly in 115 patients, quarterly in 637, and semiannually in 180. Nearly half of the patients had locally advanced disease. In comparison with baseline, median serum PSA levels were reduced at 12 months by at least 99.7% in the three strata (P &lt;0.001 in all cases). Sexual impotence and hot flashes were the most frequently reported toxicities. Conclusion: To our knowledge, this is the largest assessment of real-world data on alternative schedules of leuprolide in a Brazilian population. Our study suggests that PSA levels can be effectively be reduced in most patients treated with monthly, quarterly, or semiannual injections of long-acting leuprolide acetate.
DOI: 10.6084/m9.figshare.12056583.v1
title: Effect of the addition of metakaolin on the carbonation of Portland cement concretes

description: Abstract Carbonation has been a concern of constructors and researchers because, by lowering the pH of the interstitial solution of the concrete, it can favor the post-deposition and subsequent corrosion of reinforced concrete reinforcement. Among the factors that influence carbonation is the use of pozzolanic materials, such as metakaolin. However, there is no consensus as to the positive or negative contribution of these additions. This work evaluated the influence of metakaolin on the mechanical properties, porosity and in particular on the carbonation of concrete, from the addition of 0%, 5%, 10% and 15% of metakaolin, in relation to the cement mass. From the results, it was observed that the addition of metakaolin, while not significantly influencing the porosity, gave the concrete a greater resistance to axial compression, a decrease in the capillary absorption and delayed the advance of the carbonation front in the concrete.
DOI: 10.6084/m9.figshare.12056568
title: Profile of sexuality and symptoms of lower urinary tract in non-institutionalized elderly

description: ABSTRACT Introduction: Urinary or sexual dysfunction in the elderly are underreported. However, they are highly prevalent. This study aims to identify the prevalence of these conditions. Objective: The aim is to carry out an investigation in non-institutionalized individuals over 60 years of age, to obtain data on its sexual and urinary health in São Paulo, Campinas, Santo André and Londrina. Results: 6.000 questionnaires were distributed, and 3425 were included in the study, for the analysis of the questionnaires separately. In relation to ADAM, 92% of the 1385 evaluated were suspicious of androgen deficiency (ADAM). As for the male sexual function, it was observed 37% of premature ejaculation. As for the female sexual function, 1300 (74%) did not practice sexual intercourse and the main reasons were: lack of partner and lack of sexual desire. In addition, 988 (78%) of women who had no sexual intercourse responded that they didn't want sex and, more importantly, about 22% of them would like to have sexual intercourse. International prostate symptom score (IPSS) showed gradual worsening of urinary symptoms with increasing age, being the most prevalent: nocturia and urinary urgency. As for the female IPSS, we noted that even after 80 years, the majority have mild symptoms related to voiding dysfunction; with increasing age there is a gradual increase in the result of the IPSS. Conclusion: Due to the large number of sexual and urinary disorders found, we recommend the improvement in health conditions, promoting a better quality of life in the elderly.
DOI: 10.6084/m9.figshare.12056562
title: Chemical stress reduces the lateral shoot growth in vernalized garlic

description: ABSTRACT Brazil’s low garlic productivity is attributed, mainly to the lateral shoot growth, a physiological anomaly characterized by early lateral shoot growth of cloves in noble group garlic cultivars. Considering the aforementioned information, the aim was to evaluate the occurrence of lateral shoot growth and productivity characteristics in garlic plants, cv. Chonan, subject to herbicide chemical stress. In order to do so, an experiment was conducted in outlining randomized blocks in a 3x5 factorial scheme, constituted by three herbicides (paraquat 500 g ha-1; ammonium gluphosinate 400 g ha-1 and glyphosate 720 g ha-1) and five subdoses (0, 5, 10, 15 and 20% of the minimum recommended dose of each herbicide). The electron transport rates (ETR) were evaluated after herbicide application, as well as the culture’s morphological and productive characteristics. The chemical stress caused by herbicides paraquat, ammonium gluphosinate and glyphosate in underdoses of 25, 40 and 36 i.a. ha-1, respectively, was efficient in reducing the electron transport rate and the lateral shoot growth of the Chonan garlic cultivar, and also technically viable in increasing the productivity of commercial bulbs.
DOI: 10.6084/m9.figshare.12056574
title: The latin model in the first descriptions of the Mapudungun language: heritage and innovation in colonial-missionary linguistics

description: Abstract This article describes and explains the use of the comparative paradigm in the study of the Mapudungun language, which took Latin as a model because it was a prestigious language and because it had a strong grammatical tradition. In particular, the paper analyzes the procedures to describe the Mapuche language in the missionary grammars, in relation to the missionaries’ linguistic experimentation. For illustrative purposes, the grammatical category ‘noun’ is used and the study shows that exogenous explanations prevailed in the first descriptions of the Mapudungun language, despite which the syntactic and morphological particularities of this language were manifested.
DOI: 10.6084/m9.figshare.12056562.v1
title: Chemical stress reduces the lateral shoot growth in vernalized garlic

description: ABSTRACT Brazil’s low garlic productivity is attributed, mainly to the lateral shoot growth, a physiological anomaly characterized by early lateral shoot growth of cloves in noble group garlic cultivars. Considering the aforementioned information, the aim was to evaluate the occurrence of lateral shoot growth and productivity characteristics in garlic plants, cv. Chonan, subject to herbicide chemical stress. In order to do so, an experiment was conducted in outlining randomized blocks in a 3x5 factorial scheme, constituted by three herbicides (paraquat 500 g ha-1; ammonium gluphosinate 400 g ha-1 and glyphosate 720 g ha-1) and five subdoses (0, 5, 10, 15 and 20% of the minimum recommended dose of each herbicide). The electron transport rates (ETR) were evaluated after herbicide application, as well as the culture’s morphological and productive characteristics. The chemical stress caused by herbicides paraquat, ammonium gluphosinate and glyphosate in underdoses of 25, 40 and 36 i.a. ha-1, respectively, was efficient in reducing the electron transport rate and the lateral shoot growth of the Chonan garlic cultivar, and also technically viable in increasing the productivity of commercial bulbs.
DOI: 10.6084/m9.figshare.12056568.v1
title: Profile of sexuality and symptoms of lower urinary tract in non-institutionalized elderly

description: ABSTRACT Introduction: Urinary or sexual dysfunction in the elderly are underreported. However, they are highly prevalent. This study aims to identify the prevalence of these conditions. Objective: The aim is to carry out an investigation in non-institutionalized individuals over 60 years of age, to obtain data on its sexual and urinary health in São Paulo, Campinas, Santo André and Londrina. Results: 6.000 questionnaires were distributed, and 3425 were included in the study, for the analysis of the questionnaires separately. In relation to ADAM, 92% of the 1385 evaluated were suspicious of androgen deficiency (ADAM). As for the male sexual function, it was observed 37% of premature ejaculation. As for the female sexual function, 1300 (74%) did not practice sexual intercourse and the main reasons were: lack of partner and lack of sexual desire. In addition, 988 (78%) of women who had no sexual intercourse responded that they didn't want sex and, more importantly, about 22% of them would like to have sexual intercourse. International prostate symptom score (IPSS) showed gradual worsening of urinary symptoms with increasing age, being the most prevalent: nocturia and urinary urgency. As for the female IPSS, we noted that even after 80 years, the majority have mild symptoms related to voiding dysfunction; with increasing age there is a gradual increase in the result of the IPSS. Conclusion: Due to the large number of sexual and urinary disorders found, we recommend the improvement in health conditions, promoting a better quality of life in the elderly.
DOI: 10.6084/m9.figshare.12056574.v1
title: The latin model in the first descriptions of the Mapudungun language: heritage and innovation in colonial-missionary linguistics

description: Abstract This article describes and explains the use of the comparative paradigm in the study of the Mapudungun language, which took Latin as a model because it was a prestigious language and because it had a strong grammatical tradition. In particular, the paper analyzes the procedures to describe the Mapuche language in the missionary grammars, in relation to the missionaries’ linguistic experimentation. For illustrative purposes, the grammatical category ‘noun’ is used and the study shows that exogenous explanations prevailed in the first descriptions of the Mapudungun language, despite which the syntactic and morphological particularities of this language were manifested.
DOI: 10.6084/m9.figshare.12056553
title: Effects of UV-C radiation on minimally processed lettuce and apple: a review

description: Abstract The increasing demand for nutritive, ready-to-eat foods has prompted the minimally processed (MP) fruits and vegetables market. However, these foods have short shelf-live, marked by their rapid deterioration. Ultraviolet-C (UV-C) radiation is a clean, low-cost and non-thermal technique that can be an alternative to commonly used sanitizers. However, this conservation method has a limited application in this branch of industry due to its low penetration in foods. The objective of this review was to evaluate the germicidal effect of UV-C radiation on minimally processed lettuce and apple, the possible damage to physical and sensorial properties, as well as the factors involved in this technique. A log reduction from 1 to 2 log CFU/g of the natural microflora of these vegetables can be easily achieved at moderate doses, for diverse groups of spoilage microorganisms. A higher reduction level above 4 log CFU/g of inoculated pathogens was accomplished, when higher doses were applied. For MP lettuce, its irregular surface is considered a limiting factor due to contact attenuation between radiation and microorganisms. This limitation can be overcome by changing process parameters, such as distance from the emitting source and exposing both sides of the lettuce. The color of the leaves was better preserved with the use of UV-C radiation at moderate doses. Undesired alterations in MP apple, such as intense weight loss and pronounced browning were associated to severe cell damage at higher doses. By exposing the fruit for a shorter time, these alterations could be prevented. In general, there was good acceptability of MP lettuce and apple treated with UV-C. The vegetable type and its topography had an important influence on the efficiency of the technique. It was not possible to suggest an adequate dosage for each vegetable seeing that there are few availabe studies that differ between each other in terms of the vegetable variety, the way treatments were conducted and the exposed dose.
DOI: 10.6084/m9.figshare.12056553.v1
title: Effects of UV-C radiation on minimally processed lettuce and apple: a review

description: Abstract The increasing demand for nutritive, ready-to-eat foods has prompted the minimally processed (MP) fruits and vegetables market. However, these foods have short shelf-live, marked by their rapid deterioration. Ultraviolet-C (UV-C) radiation is a clean, low-cost and non-thermal technique that can be an alternative to commonly used sanitizers. However, this conservation method has a limited application in this branch of industry due to its low penetration in foods. The objective of this review was to evaluate the germicidal effect of UV-C radiation on minimally processed lettuce and apple, the possible damage to physical and sensorial properties, as well as the factors involved in this technique. A log reduction from 1 to 2 log CFU/g of the natural microflora of these vegetables can be easily achieved at moderate doses, for diverse groups of spoilage microorganisms. A higher reduction level above 4 log CFU/g of inoculated pathogens was accomplished, when higher doses were applied. For MP lettuce, its irregular surface is considered a limiting factor due to contact attenuation between radiation and microorganisms. This limitation can be overcome by changing process parameters, such as distance from the emitting source and exposing both sides of the lettuce. The color of the leaves was better preserved with the use of UV-C radiation at moderate doses. Undesired alterations in MP apple, such as intense weight loss and pronounced browning were associated to severe cell damage at higher doses. By exposing the fruit for a shorter time, these alterations could be prevented. In general, there was good acceptability of MP lettuce and apple treated with UV-C. The vegetable type and its topography had an important influence on the efficiency of the technique. It was not possible to suggest an adequate dosage for each vegetable seeing that there are few availabe studies that differ between each other in terms of the vegetable variety, the way treatments were conducted and the exposed dose.
DOI: 10.6084/m9.figshare.12056544
title: Systematic review of the effect of probiotics on experimental gingivitis in humans

description: Abstract: Probiotic therapy is a viable alternative to chlorhexidine, a widely used antiseptic in dentistry that produces significant adverse effects. This systematic review aimed to analyze the effects of probiotics on experimental gingivitis in humans. Two independent reviewers conducted a comprehensive literature search until March 2019. Randomized clinical trials and controlled clinical trials were selected. Outcome data were extracted and critically analyzed. A total of five articles were included in the qualitative synthesis. No meta-analysis could be conducted due to the heterogeneity of the selected studies. The use of probiotics showed a slight improvement in clinical parameters. Changes in gingival crevicular fluid volume were lower in the presence of the probiotic than in the placebo group. All the studies showed that the immediate, positive effects of probiotics during the period of discontinued mechanical oral hygiene were due to the modulation of the host response, not the anti-plaque effect. Investigators should conduct randomized clinical trials to elucidate the mechanisms of probiotic action and develop improved delivery systems.
DOI: 10.6084/m9.figshare.12056550
title: ROOTING ENVIRONMENTS IN Sequoia sempervirens MINI-CUTTINGS OF CLONE A228

description: ABSTRACT Sequoia sempervirens is different from other species not only for its excellent vigor and longevity, but also for quality wood productivity. The objective of this work was to evaluate the rooting of Sequoia sempervirens mini-cuttings in different cultivation environments. In both experiments, rooting was evaluated in time to determine the root development in each environment. Mini-cuttings from clone A228 from clonal mini-garden were used. In the first experiment the material was placed to take root in three different environments: greenhouse (GH), shadehouse (SH) and mini-tunnel, with evaluation performed every 30 days (from 30 to 150 days). In the second experiment, we compared the development and rooting in mini-tunnel, greenhouse with intermittent mist (GWIM), with weekly evaluations (from 30 to 93 days). Both experiments were installed in a completely randomized design, with subsequent evaluation of the survival percentage, percentage of rooted cuttings and number of roots emitted by rooted cuttings. Humidity and temperature data were also collected in all environments observed. The mini-tunnel was the most efficient place for sequoia mini-cutting, presenting higher survival, rooting and number of roots when compared to the shadehouse and the greenhouse. In addition, it provided rooting similar to the greenhouse with intermittent mist (close to 90%). It is recommended to keep mini-cuttings in a mini-tunnel or greenhouse with intermittent mist for a period of 90 days for proper rooting to occur. Good temperature control was also observed in this structure, as well as excellent humidity control. The mini-tunnel can be used for sequoia propagation by mini-cuttings as it has shown good rooting results (&gt; 80%).
DOI: 10.6084/m9.figshare.12056550.v1
title: ROOTING ENVIRONMENTS IN Sequoia sempervirens MINI-CUTTINGS OF CLONE A228

description: ABSTRACT Sequoia sempervirens is different from other species not only for its excellent vigor and longevity, but also for quality wood productivity. The objective of this work was to evaluate the rooting of Sequoia sempervirens mini-cuttings in different cultivation environments. In both experiments, rooting was evaluated in time to determine the root development in each environment. Mini-cuttings from clone A228 from clonal mini-garden were used. In the first experiment the material was placed to take root in three different environments: greenhouse (GH), shadehouse (SH) and mini-tunnel, with evaluation performed every 30 days (from 30 to 150 days). In the second experiment, we compared the development and rooting in mini-tunnel, greenhouse with intermittent mist (GWIM), with weekly evaluations (from 30 to 93 days). Both experiments were installed in a completely randomized design, with subsequent evaluation of the survival percentage, percentage of rooted cuttings and number of roots emitted by rooted cuttings. Humidity and temperature data were also collected in all environments observed. The mini-tunnel was the most efficient place for sequoia mini-cutting, presenting higher survival, rooting and number of roots when compared to the shadehouse and the greenhouse. In addition, it provided rooting similar to the greenhouse with intermittent mist (close to 90%). It is recommended to keep mini-cuttings in a mini-tunnel or greenhouse with intermittent mist for a period of 90 days for proper rooting to occur. Good temperature control was also observed in this structure, as well as excellent humidity control. The mini-tunnel can be used for sequoia propagation by mini-cuttings as it has shown good rooting results (&gt; 80%).
DOI: 10.6084/m9.figshare.12056544.v1
title: Systematic review of the effect of probiotics on experimental gingivitis in humans

description: Abstract: Probiotic therapy is a viable alternative to chlorhexidine, a widely used antiseptic in dentistry that produces significant adverse effects. This systematic review aimed to analyze the effects of probiotics on experimental gingivitis in humans. Two independent reviewers conducted a comprehensive literature search until March 2019. Randomized clinical trials and controlled clinical trials were selected. Outcome data were extracted and critically analyzed. A total of five articles were included in the qualitative synthesis. No meta-analysis could be conducted due to the heterogeneity of the selected studies. The use of probiotics showed a slight improvement in clinical parameters. Changes in gingival crevicular fluid volume were lower in the presence of the probiotic than in the placebo group. All the studies showed that the immediate, positive effects of probiotics during the period of discontinued mechanical oral hygiene were due to the modulation of the host response, not the anti-plaque effect. Investigators should conduct randomized clinical trials to elucidate the mechanisms of probiotic action and develop improved delivery systems.
DOI: 10.6084/m9.figshare.12056538
title: Effects of oral isotretinoin therapy on the nasal cavities,

description: Abstract Introduction Isotretinoin (13 cis-retinoic acid) is the most effective treatment for acne vulgaris and is the only treatment option that can provide either remission or a permanent cure. Objective The aim of this study was to use both subjective and objective methods to assess the nasal complaints of patients with severe acne who received oral isotretinoin therapy. Methods Fifty-four subjects were enrolled in the study. All the subjects were assessed with subjective (NOSE and VAS questionnaires) and objective (rhinomanometry and saccharine) tests to determine the severity of their nasal complaints. Results The mean severity scores (min: 0; max: 100) for nasal dryness/crusting and epistaxis were 0.47 ± 1.48 (0-5); 0.35 ± 1.30 (0-5) at admission, 3.57 ± 4.45 (0-10); 2.26 ± 4.71 (0-20) at the first month, and 4.28 ± 6 (0-20); 2.26 ± 4.71 (0-20) at the third month of the treatment respectively. Total nasal resistance of 0.195 ± 0.079 (0.12-0.56) Pa/cm3/s at admission, 0.21 ± 0.084 (0.12-0.54) Pa/cm3/s at the first month, and 0.216 ± 0.081 (0.14-0.54) Pa/cm3/s at the third month. Conclusion Oral isotretinoin therapy can cause the complaint of nasal obstruction. In addition, nasal complaints, such as dryness/crusting and epistaxis, significantly increase in patients during the therapy schedule.