cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.7270/q2z320wr
title: BindingDB Entry 50041788: 1-Aryl-3,4-dihydroisoquinoline inhibitors of JNK3.

description: Small molecule binding data for protein Cyclin-dependent kinase 2, Epidermal growth factor receptor, Epidermal growth factor receptor and ErbB2 (HER1 and HER2), Glycogen synthase kinase-3, Inhibitor of NF-kappa-B kinase (IKK), MAP kinase ERK2, Macrophage colony stimulating factor receptor, Mitogen-activated protein kinase 10, Mitogen-activated protein kinase 14, Mitogen-activated protein kinase 9, Mitogen-activated protein kinase kinase kinase 11, RAF serine/threonine protein kinase, Rho-associated protein kinase, SRC, Serine/threonine-protein kinase PLK1, Serine/threonine-protein kinase Sgk1, and c-Jun N-terminal kinase, JNK, Uniprot O00141, O14920, O15111, P00533, P04626, P06239, P07333, P15056, P24941, P28482, P45983, P45984, P49841, P53350, P53779, Q13464, Q16539, and Q16584
DOI: 10.7270/q2zw1n3v
title: BindingDB Entry 50041052: Synthesis and structure-activity relationship of 2-(aminoalkyl)-2,3,3a,8-tetrahydrodibenzo[c,f]isoxazolo[2,3-a]azepine derivatives: a novel series of 5-HT(2A/2C) receptor antagonists. Part 2.

description: Small molecule binding data for protein 5-Hydroxytryptamine receptor 2A (5-HT2A), 5-Hydroxytryptamine receptor 2C (5-HT2C), 5-hydroxytryptamine receptor 1A, 5-hydroxytryptamine receptor 1D, Alpha-1A adrenergic receptor, Alpha-2A adrenergic receptor, Alpha-2C adrenergic receptor, Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor, Dopamine receptor, Dopamine receptor D2L/neurotensin receptor NTS1, Dopamine receptors; D2 & D4, and Histamine H1 receptor, Uniprot P08908, P08913, P14416, P18825, P21917, P28221, P28223, P28335, P35348, P35367, P35462, P61169, and Q4W594
DOI: 10.7270/q20c4wwb
title: BindingDB Entry 50040540: [18F](R)-5-chloro-1-(1-cyclopropyl-2-methoxyethyl)-3-(4-(2-fluoroethoxy)-2,5-dimethyl phenylamino)pyrazin-2(1H)-one: introduction of N3-phenylpyrazinones as potential CRF-R1 PET imaging agents.

description: Small molecule binding data for protein Corticotropin releasing factor receptor and Corticotropin releasing factor receptor 1, Uniprot P34998 and P35353
DOI: 10.7270/q21v5g6x
title: BindingDB Entry 50041796: Rigidified 2-aminopyrimidines as histamine H4 receptor antagonists: effects of substitution about the rigidifying ring.

description: Small molecule binding data for protein Histamine H3 receptor, Histamine H4 Receptor, Histamine receptor (H3), and Histamine receptor (H4), Uniprot Q91ZY1, Q9H3N8, Q9QYN8, and Q9Y5N1
DOI: 10.7270/q22j6cxp
title: BindingDB Entry 50040105: Isolation and structural elucidation of cyclic tetrapeptides from Onychocola sclerotica.

description: Small molecule binding data for protein Voltage-gated potassium channel, Uniprot Q12809
DOI: 10.7270/q22n53fr
title: BindingDB Entry 50041059: Insertion of 2-carboxysuccinate and tricarballylic acid fragments into cyclic-pseudopeptides: new antagonists for the human tachykinin NK-2 receptor.

description: Small molecule binding data for protein Neurokinin 2 receptor, Uniprot P79218
DOI: 10.7270/q2445nkm
title: BindingDB Entry 50040539: Discovery of phosphoinositide 3-kinases (PI3K) p110ß isoform inhibitor 4-[2-hydroxyethyl(1-naphthylmethyl)amino]-6-[(2S)-2-methylmorpholin-4-yl]-1H-pyrimidin-2-one, an effective antithrombotic agent without associated bleeding and insulin resistance.

description: Small molecule binding data for protein Cytochrome P450 2C9, Cytochrome P450 3A, PI3-kinase subunit alpha, PI3-kinase subunit beta, PI3-kinase subunit delta, and PI3-kinase subunit gamma, Uniprot O00329, P08684, P11712, P42336, P42338, and P48736
DOI: 10.7270/q25140hr
title: BindingDB Entry 50042313: New 2-(aryloxy)-3-phenylpropanoic acids as peroxisome proliferator-activated receptora/¿ dual agonists able to upregulate mitochondrial carnitine shuttle system gene expression.

description: Small molecule binding data for protein Peroxisome proliferator-activated receptor and Peroxisome proliferator-activated receptor alpha (PPAR alpha), Uniprot P37231 and Q07869
DOI: 10.7270/q27w6d91
title: BindingDB Entry 50040538: Structure-guided design, synthesis and biological evaluation of novel DNA ligase inhibitors with in vitro and in vivo anti-staphylococcal activity.

description: Small molecule binding data for protein Cytochrome P450 2C9, Cytochrome P450 2D6 (2D6), Cytochrome P450 3A, and DNA ligase, Uniprot P08684, P10635, P11712, and Q9AIU7
DOI: 10.7270/q2b27wg3
title: BindingDB Entry 50041057: Six-membered cyclic ureas as HIV-1 protease inhibitors: a QSAR study based on CODESSA PRO approach. Quantitative structure-activity relationships.

description: Small molecule binding data for protein Human immunodeficiency virus type 1 protease
DOI: 10.7270/q2cn751r
title: BindingDB Entry 50040537: Phenylalanine derivatives as GPR142 agonists for the treatment of type II diabetes.

description: Small molecule binding data for protein Probable G-protein coupled receptor 142, Uniprot Q7TQN9 and Q7Z601
DOI: 10.7270/q2dj5gz3
title: BindingDB Entry 50042311: Development of second-generation indole-based dynamin GTPase inhibitors.

description: Small molecule binding data for protein Dynamin-2, Uniprot P39052 and P50570
DOI: 10.7270/q2dr2wk2
title: BindingDB Entry 50040110: Synthesis and biological evaluation of new N-acyl-homoserine-lactone analogues, based on triazole and tetrazole scaffolds, acting as LuxR-dependent quorum sensing modulators.

description: Small molecule binding data for protein Transcriptional activator protein luxR, Uniprot P12746
DOI: 10.7270/q2f47qdr
title: BindingDB Entry 50041792: Synthesis and cytotoxic activity of 2-methylimidazo[1,2-a]pyridine- and quinoline-substituted 2-aminopyrimidine derivatives.

description: Small molecule binding data for protein Cyclin-Dependent Kinase 1 (CDK1), Uniprot P06493 and P14635
DOI: 10.7270/q2ft8n6h
title: BindingDB Entry 50041056: Synthesis and muscarinic M(2) subtype antagonistic activity of enantiomeric pairs of 3-demethylhimbacine (3-norhimbacine) and its C(4)-epimer.

description: Small molecule binding data for protein Muscarinic acetylcholine receptor M1 and Muscarinic receptor M2 and M3, Uniprot P08482 and P10980
DOI: 10.7270/q2j967q8
title: BindingDB Entry 50042310: On scaffold hopping: challenges in the discovery of sulfated small molecules as mimetics of glycosaminoglycans.

description: Small molecule binding data for protein Prothrombin, Uniprot P00734
DOI: 10.7270/q2n58nhv
title: BindingDB Entry 50040535: Design and characterization of a selenium-containing inhibitor of activated thrombin-activatable fibrinolysis inhibitor (TAFIa), a zinc-containing metalloprotease.

description: Small molecule binding data for protein Carboxypeptidase B and Thrombin-activable fibrinolysis inhibitor (TAFIa), Uniprot P09955 and Q96IY4
DOI: 10.7270/q2p270f0
title: BindingDB Entry 50042309: Organosilicon molecules with medicinal applications.

description: Small molecule binding data for protein Angiotensin-converting enzyme, Serotonin and norepinephrine transporters (SERT/NET), Sodium-dependent dopamine transporter, and Sodium-dependent noradrenaline transporter, Uniprot P12821, P23975, P31645, and Q01959
DOI: 10.7270/q2p84d02
title: BindingDB Entry 50040108: Synthesis and evaluation of the quorum sensing inhibitory effect of substituted triazolyldihydrofuranones.

description: Small molecule binding data for protein Transcriptional activator protein luxR, Uniprot P12746
DOI: 10.7270/q2st7r4k
title: BindingDB Entry 50042308: Highly potent and selective fluorescent antagonists of the human adenosine A3 receptor based on the 1,2,4-triazolo[4,3-a]quinoxalin-1-one scaffold.

description: Small molecule binding data for protein Adenosine receptor A1 and Adenosine receptor A3, Uniprot P0DMS8 and P30542
DOI: 10.7270/q2t154rt
title: BindingDB Entry 50040107: Exploration of diverse hinge-binding scaffolds for selective Aurora kinase inhibitors.

description: Small molecule binding data for protein Aurora kinase B/Inner centromere protein, CaM kinase IV, Epidermal growth factor receptor, Glycogen synthase kinase-3, Hepatocyte growth factor receptor, Insulin-like growth factor I receptor, Interleukin-1 receptor-associated kinase 4, JAK3/JAK1, MAP kinase ERK2, Neurotrophic tyrosine kinase receptor, Rho-associated protein kinase, SRC, Serine/threonine-protein kinase Aurora, Serine/threonine-protein kinase Chk1, Serine/threonine-protein kinase PLK4, Serine/threonine-protein kinase receptor R3, Tyrosine-protein kinase JAK2, Tyrosine-protein kinase receptor FLT3, VEGF-receptor 2 and tyrosine-protein kinase SRC, Vascular endothelial growth factor receptor 2, and c-Jun N-terminal kinase, JNK, Uniprot O00444, O14757, O14965, O60674, O75116, P00533, P04629, P06239, P08069, P08581, P12931, P28482, P35968, P36888, P37023, P45983, P49840, P52333, Q16566, Q96GD4, and Q9NWZ3
DOI: 10.7270/q2vq33s9
title: BindingDB Entry 50040541: Identification of a glutathione peroxidase inhibitor that reverses resistance to anticancer drugs in human B-cell lymphoma cell lines.

description: Small molecule binding data for protein Glutathione peroxidase 1 (GPx), Uniprot P07203
DOI: 10.7270/q2x34zqj
title: BindingDB Entry 50041797: Discovery of a new series of 5-HT1A receptor agonists.

description: Small molecule binding data for protein 5-hydroxytryptamine receptor 1A, Adrenergic alpha1B, Alpha-1A adrenergic receptor, and Alpha-1D adrenergic receptor, Uniprot P08908, P25100, P35348, and P35368
DOI: 10.7270/q2xs5wgv
title: BindingDB Entry 50040106: 3-Phenyl-1H-5-pyrazolylamine-based derivatives as potent and efficacious inhibitors of FMS-like tyrosine kinase-3 (FLT3).

description: Small molecule binding data for protein Serine/threonine-protein kinase Aurora, Tyrosine-protein kinase receptor FLT3, Vascular endothelial growth factor receptor, and Vascular endothelial growth factor receptor 2, Uniprot L7RSL3, O14965, P17948, P35968, and P36888
DOI: 10.7270/q21837tg
title: BindingDB Entry 50042314: Pyrazolo[1,5-c]quinazoline derivatives and their simplified analogues as adenosine receptor antagonists: synthesis, structure-affinity relationships and molecular modeling studies.

description: Small molecule binding data for protein Adenosine receptor A1, Adenosine receptor A2a, Adenosine receptor A2b, and Adenosine receptor A3, Uniprot P0DMS8, P29274, P29275, and P30542
DOI: 10.7270/q21j9bv6
title: BindingDB Entry 50040113: Pyrimidinopyrimidine inhibitors of ketohexokinase: exploring the ring C2 group that interacts with Asp-27B in the ligand binding pocket.

description: Small molecule binding data for protein 5'-AMP-activated protein kinase Complex 1, AKT/p21CIP1, Activin receptor type-1B, CaM kinase I delta, Casein kinase I isoform delta, Cyclin-Dependent Kinase 1 (CDK1), Death-associated protein kinase 3, EPHB1, Epidermal growth factor receptor, Glycogen synthase kinase-3, Insulin receptor, Interleukin-1 receptor-associated kinase 4, Ketohexokinase, Mitogen-activated protein kinase 13 (MAPK13), Neurotrophic tyrosine kinase receptor, Platelet-derived growth factor receptor beta, Protein kinase C theta type, Rho-associated protein kinase, Ribosomal protein S6 kinase alpha 3, Serine/threonine-protein kinase Aurora, Serine/threonine-protein kinase CHK2, Serine/threonine-protein kinase Chk1, Serine/threonine-protein kinase MST4, Serine/threonine-protein kinase Nek2, Serine/threonine-protein kinase PIM, Serine/threonine-protein kinase PLK3, Tyrosine-protein kinase ABL1, Tyrosine-protein kinase JAK2, VEGF-receptor 2 and tyrosine-protein kinase SRC, cAMP-dependent protein kinase (PKA), and p21-Activated kinase 3 (PAK3), Uniprot O14757, O14965, O15264, O43293, O60674, O75914, O96017, P00519, P00533, P04629, P06213, P06493, P09619, P12931, P14635, P17612, P31749, P36896, P48730, P49841, P50053, P51812, P51955, P54619, P54762, Q04759, Q13131, Q13464, Q8IU85, Q9H4B4, Q9NWZ3, Q9P1W9, Q9P289, and Q9Y478
DOI: 10.7270/q2348mh4
title: BindingDB Entry 50040547: Synthesis and biological characterization of a series of novel diaryl amide M1 antagonists.

description: Small molecule binding data for protein Muscarinic acetylcholine receptor, Muscarinic acetylcholine receptor M1, Muscarinic acetylcholine receptor M1/M5 chimeric protein, Muscarinic acetylcholine receptor M2, and Muscarinic acetylcholine receptor M2 and M4, Uniprot P08172, P08173, P08912, P11229, and P20309
DOI: 10.7270/q24m95rd
title: BindingDB Entry 50041803: In vitro TRPV1 activity of piperine derived amides.

description: Small molecule binding data for protein Transient receptor potential cation channel subfamily V member 1, Uniprot Q8NER1
DOI: 10.7270/q25b03j1
title: BindingDB Entry 50040112: Synthesis and in vitro evaluation ofa-synuclein ligands.

description: Small molecule binding data for protein Alpha-synuclein, Uniprot P37840
DOI: 10.7270/q26974s6
title: BindingDB Entry 50041058: Non-peptide alpha(v)beta(3) antagonists. Part 5: identification of potent RGD mimetics incorporating 2-aryl beta-amino acids as aspartic acid replacements.

description: Small molecule binding data for protein Integrin beta-3/Vitronectin receptor alpha, Uniprot P05106 and P06756
DOI: 10.7270/q28s4r7s
title: BindingDB Entry 50042312: Discovery of novel and ligand-efficient inhibitors of Plasmodium falciparum and Plasmodium vivax N-myristoyltransferase.

description: Small molecule binding data for protein Myristoyl-CoA:protein N-myristoyltransferase (Nmt), Uniprot P30419
DOI: 10.15468/dl.jybqeb
title: Occurrence Download

description: A dataset containing 12949 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Pterocles alchata (Linnaeus, 1766)",
 "BasisOfRecord is one of (Human Observation, Observation)",
 "Country is Spain",
 "HasGeospatialIssue is false",
 "HasCoordinate is true",
 {
 "or" : [
 "CoordinateUncertaintyInMeters is less than 1000",
 "CoordinateUncertaintyInMeters is null"
 ]
 },
 "DistanceFromCentroidInMeters is greater than or equal to 2000",
 "OccurrenceStatus is Present",
 "Year is greater than or equal to 2015"
 ]
}

 The dataset includes 12949 records from 8 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0021528-250402121839773/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.6084/m9.figshare.16893238
title: Additional file 6 of The role of MORC3 in silencing transposable elements in mouse embryonic stem cells

description: Additional file 6: Table S5. List of primers.
DOI: 10.6084/m9.figshare.16893223
title: Additional file 2 of The role of MORC3 in silencing transposable elements in mouse embryonic stem cells

description: Additional file 2: Table S1. Illumina GoldenGate SNP genotyping assay.
DOI: 10.6084/m9.figshare.16893148
title: Additional file 2 of Waist-to-height ratio, an optimal anthropometric indicator for metabolic dysfunction associated fatty liver disease in the Western Chinese male population

description: Additional file 2: Supplementary Table S2. Binary logistic regression analysis of anthropometric indicators in predicting MAFLD.
DOI: 10.6084/m9.figshare.16893148.v1
title: Additional file 2 of Waist-to-height ratio, an optimal anthropometric indicator for metabolic dysfunction associated fatty liver disease in the Western Chinese male population

description: Additional file 2: Supplementary Table S2. Binary logistic regression analysis of anthropometric indicators in predicting MAFLD.
DOI: 10.6084/m9.figshare.21087537.v1
title: Additional file 10 of Transcriptional regulation of proanthocyanidin biosynthesis pathway genes and transcription factors in Indigofera stachyodes Lindl. roots

description: Additional file 10.
DOI: 10.6084/m9.figshare.21087543
title: Additional file 1 of Transcriptional regulation of proanthocyanidin biosynthesis pathway genes and transcription factors in Indigofera stachyodes Lindl. roots

description: Additional file 1.
DOI: 10.6084/m9.figshare.21087561.v1
title: Additional file 7 of Transcriptional regulation of proanthocyanidin biosynthesis pathway genes and transcription factors in Indigofera stachyodes Lindl. roots

description: Additional file 7.
DOI: 10.6084/m9.figshare.21087537
title: Additional file 10 of Transcriptional regulation of proanthocyanidin biosynthesis pathway genes and transcription factors in Indigofera stachyodes Lindl. roots

description: Additional file 10.
DOI: 10.6084/m9.figshare.21087555.v1
title: Additional file 5 of Transcriptional regulation of proanthocyanidin biosynthesis pathway genes and transcription factors in Indigofera stachyodes Lindl. roots

description: Additional file 5.
DOI: 10.6084/m9.figshare.21087558
title: Additional file 6 of Transcriptional regulation of proanthocyanidin biosynthesis pathway genes and transcription factors in Indigofera stachyodes Lindl. roots

description: Additional file 6.
DOI: 10.6084/m9.figshare.21087540
title: Additional file 11 of Transcriptional regulation of proanthocyanidin biosynthesis pathway genes and transcription factors in Indigofera stachyodes Lindl. roots

description: Additional file 11.
DOI: 10.6084/m9.figshare.21087564
title: Additional file 8 of Transcriptional regulation of proanthocyanidin biosynthesis pathway genes and transcription factors in Indigofera stachyodes Lindl. roots

description: Additional file 8.
DOI: 10.6084/m9.figshare.21087546.v1
title: Additional file 2 of Transcriptional regulation of proanthocyanidin biosynthesis pathway genes and transcription factors in Indigofera stachyodes Lindl. roots

description: Additional file 2.
DOI: 10.6084/m9.figshare.21087540.v1
title: Additional file 11 of Transcriptional regulation of proanthocyanidin biosynthesis pathway genes and transcription factors in Indigofera stachyodes Lindl. roots

description: Additional file 11.
DOI: 10.6084/m9.figshare.21087546
title: Additional file 2 of Transcriptional regulation of proanthocyanidin biosynthesis pathway genes and transcription factors in Indigofera stachyodes Lindl. roots

description: Additional file 2.
DOI: 10.6084/m9.figshare.21087552
title: Additional file 4 of Transcriptional regulation of proanthocyanidin biosynthesis pathway genes and transcription factors in Indigofera stachyodes Lindl. roots

description: Additional file 4.
DOI: 10.6084/m9.figshare.21087567
title: Additional file 9 of Transcriptional regulation of proanthocyanidin biosynthesis pathway genes and transcription factors in Indigofera stachyodes Lindl. roots

description: Additional file 9.
DOI: 10.6084/m9.figshare.7421717
title: Additional file 2: of Genomic identification and functional analysis of essential genes in Caenorhabditis elegans

description: Identifications of essential genes. Including information about the allele name, the strain name, the genetic mapping zones [33], location, predicted gene, allele mutation, RNAi support, alleles support, and MMP support of the essential genes. The asterisk (*) signify a stop codon. (XLS 43 kb)
DOI: 10.6084/m9.figshare.21087558.v1
title: Additional file 6 of Transcriptional regulation of proanthocyanidin biosynthesis pathway genes and transcription factors in Indigofera stachyodes Lindl. roots

description: Additional file 6.
DOI: 10.6084/m9.figshare.20047370
title: Methods Comparison Results

description: Methods Comparison Results of our manuscript "Advancing UN Comtrade for Physical Trade Flow Analysis: Addressing the Issue of Missing Values"
DOI: 10.6084/m9.figshare.21087552.v1
title: Additional file 4 of Transcriptional regulation of proanthocyanidin biosynthesis pathway genes and transcription factors in Indigofera stachyodes Lindl. roots

description: Additional file 4.
DOI: 10.6084/m9.figshare.21087555
title: Additional file 5 of Transcriptional regulation of proanthocyanidin biosynthesis pathway genes and transcription factors in Indigofera stachyodes Lindl. roots

description: Additional file 5.
DOI: 10.5281/zenodo.10527377
title: CMIF Ǧibrān Love Letters

description: CMIF dataset based on:

Bushrui, Suheil und Salma H. al-Kuzbari (Hrsg.): "Gibran Love Letters", One World, Oxford, 1995.

The CMIF dataset was created by students in the Eins@FU Lernwerkstatt: "Briefkorrespondenzen zwischen der arabischen Welt und Europa digital erforschen" at Freie Universität Berlin, using the CMIF Creator.
DOI: 10.5281/zenodo.10638878
title: CMIF Ǧibrān Love Letters

description: CMIF dataset based on:

Bushrui, Suheil und Salma H. al-Kuzbari (Hrsg.): "Gibran Love Letters", One World, Oxford, 1995.

The CMIF dataset was created by students in the Eins@FU Lernwerkstatt: "Briefkorrespondenzen zwischen der arabischen Welt und Europa digital erforschen" at Freie Universität Berlin, using the CMIF Creator.
DOI: 10.6084/m9.figshare.14267106.v1
title: Additional file 2 of Epigenome-wide association study of whole blood gene expression in Framingham Heart Study participants provides molecular insight into the potential role of CHRNA5 in cigarette smoking-related lung diseases

description: Additional file 2. Supplemental Tables.
DOI: 10.6084/m9.figshare.21087561
title: Additional file 7 of Transcriptional regulation of proanthocyanidin biosynthesis pathway genes and transcription factors in Indigofera stachyodes Lindl. roots

description: Additional file 7.
DOI: 10.6084/m9.figshare.21087564.v1
title: Additional file 8 of Transcriptional regulation of proanthocyanidin biosynthesis pathway genes and transcription factors in Indigofera stachyodes Lindl. roots

description: Additional file 8.
DOI: 10.6084/m9.figshare.21087567.v1
title: Additional file 9 of Transcriptional regulation of proanthocyanidin biosynthesis pathway genes and transcription factors in Indigofera stachyodes Lindl. roots

description: Additional file 9.
DOI: 10.6084/m9.figshare.7980656.v1
title: Additional file 13: of RNA-Seq and iTRAQ reveal multiple pathways involved in storage root formation and development in sweet potato (Ipomoea batatas L.)

description: Table S7. Different expressed transcription factors in transcriptome analysis. (XLS 6892 kb)
DOI: 10.6084/m9.figshare.20039304
title: Pharmacokinetics and safety of repirinast tablets in healthy Chinese subjects

description: ABSTRACT Repirinast is a new, synthetic, disodium cromoglycate-like antiallergic agent for oral administration in humans. This study evaluated the safety, tolerability and pharmacokinetics of repirinast tablets in healthy Chinese volunteers. This was a phase I, open-label, randomized, single- and multiple-dose study. Subjects were assigned to receive a single dose of repirinast tablet at either 150, 300, or 450 mg, or multiple doses of 150 mg twice daily for 5 days. Plasma samples were analyzed with LC-MS/MS. Pharmacokinetic parameters of active metabolite MY-1250 (deesterified repirinast) were calculated using non-compartmental analysis with WinNonlin software. Statistical analysis was performed using SPSS software. All adverse events (AEs) were mild and of limited duration. No serious adverse event (SAE), death or withdrawal from the study was observed. In the single-dose study, Cmax was reached at about 0.75 hour, and the mean t1/2 was approximately 16.21 hours. Area under curve (AUC) and Cmax increased with dose escalation, but dose proportionality was not observed over the range of 150 to 450 mg. In the multiple-dose study, the steady-state was reached within 3 days with no accumulation. Repirinast tablet was well tolerated in healthy Chinese subjects.