cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.28468781
title: Diabetes mellitus and HbA1c as predictors of mortality in hospitalized COVID-19 patients

description: The role of diabetes mellitus (DM) in hospitalized COVID-19 patients and of HbA1c in hospitalized COVID-19 patients with DM were not studied adequately in the past. It was a retrospective cohort study. In this study, data from 305 hospitalized COVID-19 patients was analyzed. The study objective was to determine the association of DM with in-hospital mortality in COVID-19 patients. Another study objective was to determine the association of HbA1c with mortality in COVID-19 patients with DM. In this retrospective study, DM was present in 41.3% (126/305) of the study population. The multivariate Cox regression analysis showed a significant association between DM and mortality (adjusted hazard ratio (aHR): 2.116, 95% CI: 1.088–4.116, <i>p =</i> 0.027). The median HbA1c in diabetic patients was 8.9% (7.5-11.0). HbA1c was found to be associated with mortality in diabetic patients in the multivariate cox-regression analysis (aHR:1.272, 95% CI: 1.028–1.574, <i>p =</i> 0.027). The multivariate Cox regression analysis also showed the association of HbA1c (10.5%≤HbA1c &gt; 10.5%) as a dichotomous variable with in-hospital mortality (aHR: 2.53, 95% CI: 2.606–194.81, <i>p =</i> 0.005) in diabetic patients. DM was independently associated with mortality in hospitalized COVID-19 patients in the multivariate analysis. In COVID-19 patients with DM, HbA1c was associated with mortality as a continuous and dichotomous variable in the multivariate analysis.
DOI: 10.6084/m9.figshare.28468781.v1
title: Diabetes mellitus and HbA1c as predictors of mortality in hospitalized COVID-19 patients

description: The role of diabetes mellitus (DM) in hospitalized COVID-19 patients and of HbA1c in hospitalized COVID-19 patients with DM were not studied adequately in the past. It was a retrospective cohort study. In this study, data from 305 hospitalized COVID-19 patients was analyzed. The study objective was to determine the association of DM with in-hospital mortality in COVID-19 patients. Another study objective was to determine the association of HbA1c with mortality in COVID-19 patients with DM. In this retrospective study, DM was present in 41.3% (126/305) of the study population. The multivariate Cox regression analysis showed a significant association between DM and mortality (adjusted hazard ratio (aHR): 2.116, 95% CI: 1.088–4.116, <i>p =</i> 0.027). The median HbA1c in diabetic patients was 8.9% (7.5-11.0). HbA1c was found to be associated with mortality in diabetic patients in the multivariate cox-regression analysis (aHR:1.272, 95% CI: 1.028–1.574, <i>p =</i> 0.027). The multivariate Cox regression analysis also showed the association of HbA1c (10.5%≤HbA1c &gt; 10.5%) as a dichotomous variable with in-hospital mortality (aHR: 2.53, 95% CI: 2.606–194.81, <i>p =</i> 0.005) in diabetic patients. DM was independently associated with mortality in hospitalized COVID-19 patients in the multivariate analysis. In COVID-19 patients with DM, HbA1c was associated with mortality as a continuous and dichotomous variable in the multivariate analysis.
DOI: 10.6084/m9.figshare.31095229
title: <b>Moving beyond species diversity metrics: a global synthesis of plant invasion impacts on phylogenetic and functional diversity</b>

description: <b>Aim</b>Biological invasions, being one of the major drivers of global environmental change, are currently driving a worldwide decline of biodiversity. To date, several meta-analyses have synthesised impacts of biological invasions on species diversity – the most common metric for measuring biodiversity. However, an empirical synthesis of invasion impacts on functional and phylogenetic diversity – recently emerging dimensions of biodiversity measurement – remains unexplored. Here, we conducted a meta-analysis of 605 effect sizes to synthesise global plant invasion impacts on the functional and phylogenetic diversity.<b>Location</b>Global<b>Time Period</b>2015-2023<b>Major Taxa Studied</b>Invasive plant species<b>Methods</b>We employed a novel meta-analytical framework by integrating, hitherto largely ignored, deviational effects with traditional directional effects. The framework, besides quantifying the relative changes in response variables (i.e., directional effects), allowed us to measure the absolute changes in response variables from the reference values (i.e., deviational effects).<b>Results</b>Our findings show that, in terms of directional effects, invasion impacts on community-weighted functional trait and phylogenetic distance metrics are largely non-significant. Conversely, in terms of deviational effects, the invasion impacts were significant on the key functional metrics: richness, dispersion, Rao’s Q, and overall phylogenetic diversity. We also found the invasion impacts to be context-specific, with directional effects observed only in wastelands but those of deviational effects in forests, grasslands and wastelands.<b>Main Conclusions</b>These findings provide empirical evidence to posit that plant invasion impacts increase variability within communities rather than shift trait means, underscoring urgency of quantifying both directional and deviational effects in meta-analysis. By moving beyond the simple metric of species diversity, our study calls for integrating trait- and lineage-based metrics in invasion impact studies, with immense implications in measuring and managing invasion impacts on biodiversity. Leveraging on the insights gained from this global synthesis, we identify existing knowledge gaps and directions for future research.
DOI: 10.6084/m9.figshare.31095229.v1
title: <b>Moving beyond species diversity metrics: a global synthesis of plant invasion impacts on phylogenetic and functional diversity</b>

description: <b>Aim</b>Biological invasions, being one of the major drivers of global environmental change, are currently driving a worldwide decline of biodiversity. To date, several meta-analyses have synthesised impacts of biological invasions on species diversity – the most common metric for measuring biodiversity. However, an empirical synthesis of invasion impacts on functional and phylogenetic diversity – recently emerging dimensions of biodiversity measurement – remains unexplored. Here, we conducted a meta-analysis of 605 effect sizes to synthesise global plant invasion impacts on the functional and phylogenetic diversity.<b>Location</b>Global<b>Time Period</b>2015-2023<b>Major Taxa Studied</b>Invasive plant species<b>Methods</b>We employed a novel meta-analytical framework by integrating, hitherto largely ignored, deviational effects with traditional directional effects. The framework, besides quantifying the relative changes in response variables (i.e., directional effects), allowed us to measure the absolute changes in response variables from the reference values (i.e., deviational effects).<b>Results</b>Our findings show that, in terms of directional effects, invasion impacts on community-weighted functional trait and phylogenetic distance metrics are largely non-significant. Conversely, in terms of deviational effects, the invasion impacts were significant on the key functional metrics: richness, dispersion, Rao’s Q, and overall phylogenetic diversity. We also found the invasion impacts to be context-specific, with directional effects observed only in wastelands but those of deviational effects in forests, grasslands and wastelands.<b>Main Conclusions</b>These findings provide empirical evidence to posit that plant invasion impacts increase variability within communities rather than shift trait means, underscoring urgency of quantifying both directional and deviational effects in meta-analysis. By moving beyond the simple metric of species diversity, our study calls for integrating trait- and lineage-based metrics in invasion impact studies, with immense implications in measuring and managing invasion impacts on biodiversity. Leveraging on the insights gained from this global synthesis, we identify existing knowledge gaps and directions for future research.
DOI: 10.15468/usddeu
title: Records of vascular plants from the surroundings of the village of Stavyshche (Zhytomyr District, Zhytomyr Region, Ukraine)

description: In May 2025, a study was conducted on the biodiversity of the flora near Stavyshche village, Zhytomyr district, Zhytomyr region. The research aimed to find valuable areas for the establishment of new protected areas. The expedition revealed several well-preserved bogs with regionally rare plant species Carex pilosa and Equisetum hyemale, as well as a habitat from Resolution 4 of the Bern Convention - thickets of large sedges, mostly without stagnant water. We also carried out a flora inventory. In total, we compiled 13 floristic lists using the Vegapp app, which formed the basis of this dataset during 1 field trip in 2025.
This dataset contains 381 occurrences of 201 species (vascular plants) recorded in 13 releves or vegetation surveys during the project. The nomenclature of the dataset is as follows Ukrainian Plant Trait Database: UkrTrait v. 1.0 (Vynokurov et al. 2024).
DOI: 10.6084/m9.figshare.28578959
title: Alloimmunization in β-Thalassemia and Sickle Cell Disease in Middle Eastern Countries: A Systemic Review

description: Sickle cell disease and β-thalassemia are important health problems in Middle Eastern countries. Transfusion is the cornerstone of the management in these disorders, and red blood cell alloimmunization is among the well-recognized adverse effects associated with it. We reviewed the literature on published studies on alloimmunization prevalence, its associated risk factors, and transfusion policies employed in these countries. Our review included 39 studies on thalassemia (including 9005 patients), and 19 on sickle cell disease (including 3867 patients). The mean alloimmunization prevalence rate in thalassemia was 13.0% (95% CI: 10.0–15.0%), while that in sickle cell disease was 14.0% (95% CI: 10.0 − 19.0%). The distribution of the prevalence rates showed considerable heterogeneity in both diseases. The most frequent alloantibodies detected were anti-K (25.9%), Anti-E (21.8%), and Anti-D (9.2%), with Rhesus and K antibodies comprising 74.2% of all antibodies detected. Some risk factors were significant in several studies, including older age, female sex, older age at first transfusion, number of transfused units, and splenectomy. The prevalence of alloimmunization was significantly higher in retrospective studies compared to cross-sectional ones, in both thalassemia and sickle cell disease (<i>P</i> = 0.04 in each). This review reaffirmed the need to provide ABO+Rhesus + K matched blood to hemoglobinopathy patients in the Middle East, and the need for more research on Rhesus variants in this part of the world.
DOI: 10.6084/m9.figshare.28578959.v1
title: Alloimmunization in β-Thalassemia and Sickle Cell Disease in Middle Eastern Countries: A Systemic Review

description: Sickle cell disease and β-thalassemia are important health problems in Middle Eastern countries. Transfusion is the cornerstone of the management in these disorders, and red blood cell alloimmunization is among the well-recognized adverse effects associated with it. We reviewed the literature on published studies on alloimmunization prevalence, its associated risk factors, and transfusion policies employed in these countries. Our review included 39 studies on thalassemia (including 9005 patients), and 19 on sickle cell disease (including 3867 patients). The mean alloimmunization prevalence rate in thalassemia was 13.0% (95% CI: 10.0–15.0%), while that in sickle cell disease was 14.0% (95% CI: 10.0 − 19.0%). The distribution of the prevalence rates showed considerable heterogeneity in both diseases. The most frequent alloantibodies detected were anti-K (25.9%), Anti-E (21.8%), and Anti-D (9.2%), with Rhesus and K antibodies comprising 74.2% of all antibodies detected. Some risk factors were significant in several studies, including older age, female sex, older age at first transfusion, number of transfused units, and splenectomy. The prevalence of alloimmunization was significantly higher in retrospective studies compared to cross-sectional ones, in both thalassemia and sickle cell disease (<i>P</i> = 0.04 in each). This review reaffirmed the need to provide ABO+Rhesus + K matched blood to hemoglobinopathy patients in the Middle East, and the need for more research on Rhesus variants in this part of the world.
DOI: 10.15468/dl.8ur62k
title: Occurrence Download

description: A dataset containing 1168 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Litsea leefeana"
 ]
}

 The dataset includes 1168 records from 37 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0002356-260120142942310/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.6084/m9.figshare.28578956
title: Long-Term and Transient Calcium Channel Blockers; A Systematic Review of Their Role in the Management of Cardiomyopathy in Transfusion-Dependent Thalassemia

description: Calcium channel blockers (CCBs) for long-term (L) and transient (T) calcium channels (LTCC and TTCC) on cardiomyocytes have been suggested to manage iron-induced cardiomyopathy in transfusion-dependent thalassemia patients. However, the results of clinical trials on the effectiveness of CCBs have been conflicting. Here, we systematically reviewed previous studies to investigate the potential factors that could act as therapeutic modifiers and explain these discrepancies. This systematic review was conducted employing the PRISMA guideline to retrieve clinical trials and animal studies investigating the efficacy of CCBs. Studies in the following databases were collected: Web of Science, PubMed, Scopus, Google Scholar, Clinical Trials, Iranian Registry for Clinical Trials, and Cochrane CENTRAL. Keywords included the trade and generic names of various CCBs, thalassemia, and cardiomyopathy. Our Primary search resulted in 297 studies, of which 21 (n = 7 trials and n = 14 animal studies) were further analyzed. The most important parameters that could potentially influence the clinical effectiveness of CCBs in managing iron-induced cardiomyopathy included baseline cardiac iron content, diversity of iron entry routes (LTCCs, TTCCs, DMT-1, etc.), type of CCBs used, iron-induced irreversible functional/structural cardiac changes, iron-Ca<sup>2+</sup> joint metabolic dysregulation, deregulated expression of LTCCs and TTCCs, interaction of CCBs with iron chelators, disease-related complications, interactions of CCBs with various supplements used by patients, vitamin D and other nutrient deficiencies, and duration of treatment with CCBs. These items should be considered in future trials to draw more robust conclusions about the effectiveness of CCBs in preventing cardiac iron deposition and associated cardiomyopathy in TDT patients.
DOI: 10.6084/m9.figshare.28578956.v1
title: Long-Term and Transient Calcium Channel Blockers; A Systematic Review of Their Role in the Management of Cardiomyopathy in Transfusion-Dependent Thalassemia

description: Calcium channel blockers (CCBs) for long-term (L) and transient (T) calcium channels (LTCC and TTCC) on cardiomyocytes have been suggested to manage iron-induced cardiomyopathy in transfusion-dependent thalassemia patients. However, the results of clinical trials on the effectiveness of CCBs have been conflicting. Here, we systematically reviewed previous studies to investigate the potential factors that could act as therapeutic modifiers and explain these discrepancies. This systematic review was conducted employing the PRISMA guideline to retrieve clinical trials and animal studies investigating the efficacy of CCBs. Studies in the following databases were collected: Web of Science, PubMed, Scopus, Google Scholar, Clinical Trials, Iranian Registry for Clinical Trials, and Cochrane CENTRAL. Keywords included the trade and generic names of various CCBs, thalassemia, and cardiomyopathy. Our Primary search resulted in 297 studies, of which 21 (n = 7 trials and n = 14 animal studies) were further analyzed. The most important parameters that could potentially influence the clinical effectiveness of CCBs in managing iron-induced cardiomyopathy included baseline cardiac iron content, diversity of iron entry routes (LTCCs, TTCCs, DMT-1, etc.), type of CCBs used, iron-induced irreversible functional/structural cardiac changes, iron-Ca<sup>2+</sup> joint metabolic dysregulation, deregulated expression of LTCCs and TTCCs, interaction of CCBs with iron chelators, disease-related complications, interactions of CCBs with various supplements used by patients, vitamin D and other nutrient deficiencies, and duration of treatment with CCBs. These items should be considered in future trials to draw more robust conclusions about the effectiveness of CCBs in preventing cardiac iron deposition and associated cardiomyopathy in TDT patients.
DOI: 10.6084/m9.figshare.28606784
title: Rapid and Visual Molecular Detection of High Hb F Determinants; HPFH6, Asian Indian inv-del (<sup>A</sup>γδβ)<sup>0</sup>-Thalassemia, and Thai del-inv-ins (<sup>A</sup>γδβ)<sup>0</sup>-Thalassemia Using LAMP Colorimetric Phenol Red Assays

description: Hemoglobin (Hb) F, or fetal hemoglobin, is the predominant Hb in fetuses and is converted to adult hemoglobin (Hb A) at the age of 2 years. However, high Hb F levels in adults are typically present in conditions such as β-thalassemia disease and high Hb F determinants including large deletional β-globin gene clusters, and hereditary persistence of fetal hemoglobin (HPFH). The accurate detection of these conditions is crucial for effective disease management and genetic counseling. Several molecular techniques have been used to identify high Hb F determinants but require advanced instrumentation, highly skilled personnel, high cost, long time duration, and post-PCR processing. This study aimed to develop a rapid and cost-effective molecular assay for detecting common high Hb F determinants using colorimetric loop-mediated isothermal amplification (LAMP) with phenol red assays. We focused on the detection of HPFH6, Asian Indian inv-del (<sup>A</sup>γδβ)<sup>0</sup>-thalassemia, and Thai del-inv-ins (<sup>A</sup>γδβ)<sup>0</sup>-thalassemia. A total of 331 DNA samples encompassing 21 genotypes were screened using the developed LAMP assays, which were optimized to detect these determinants within 60–70 min. The assays showed high sensitivity (100%) and specificity (99.6–100%) in each mutation with detection limits of 2.5 ng/reaction. Validation by comparison with conventional methods confirmed the efficacy of the LAMP assays, which is simple, inexpensive, and suitable for use in low-resource settings. Rapid performance, visual detection, and accurate diagnosis may be useful for genetic counseling, particularly in Thailand and Southeast Asia. This innovation is suitable for application in thalassemia screening programs, especially in remote areas.
DOI: 10.6084/m9.figshare.28606784.v1
title: Rapid and Visual Molecular Detection of High Hb F Determinants; HPFH6, Asian Indian inv-del (<sup>A</sup>γδβ)<sup>0</sup>-Thalassemia, and Thai del-inv-ins (<sup>A</sup>γδβ)<sup>0</sup>-Thalassemia Using LAMP Colorimetric Phenol Red Assays

description: Hemoglobin (Hb) F, or fetal hemoglobin, is the predominant Hb in fetuses and is converted to adult hemoglobin (Hb A) at the age of 2 years. However, high Hb F levels in adults are typically present in conditions such as β-thalassemia disease and high Hb F determinants including large deletional β-globin gene clusters, and hereditary persistence of fetal hemoglobin (HPFH). The accurate detection of these conditions is crucial for effective disease management and genetic counseling. Several molecular techniques have been used to identify high Hb F determinants but require advanced instrumentation, highly skilled personnel, high cost, long time duration, and post-PCR processing. This study aimed to develop a rapid and cost-effective molecular assay for detecting common high Hb F determinants using colorimetric loop-mediated isothermal amplification (LAMP) with phenol red assays. We focused on the detection of HPFH6, Asian Indian inv-del (<sup>A</sup>γδβ)<sup>0</sup>-thalassemia, and Thai del-inv-ins (<sup>A</sup>γδβ)<sup>0</sup>-thalassemia. A total of 331 DNA samples encompassing 21 genotypes were screened using the developed LAMP assays, which were optimized to detect these determinants within 60–70 min. The assays showed high sensitivity (100%) and specificity (99.6–100%) in each mutation with detection limits of 2.5 ng/reaction. Validation by comparison with conventional methods confirmed the efficacy of the LAMP assays, which is simple, inexpensive, and suitable for use in low-resource settings. Rapid performance, visual detection, and accurate diagnosis may be useful for genetic counseling, particularly in Thailand and Southeast Asia. This innovation is suitable for application in thalassemia screening programs, especially in remote areas.
DOI: 10.6084/m9.figshare.22002158
title: Incidence, predictors, clinical outcomes, and economic burden of recurrent acute kidney injury: a retrospective cohort study

description: This study aimed to assess the incidence, predictors, mortality, and economic outcomes of recurrent Acute kidney injury (AKI) in Jordan. This was a retrospective cohort study that included adult patients who were admitted with AKI to university hospitals in the country from 2010–2019. Recurrent episodes of AKI, laboratory data, baseline medication list, and death dates were retrieved from patient’s medical records. The incidence rate of recurrent AKI was estimated. Predictors of recurrent AKI and mortality during the five years post-discharge was evaluated. Total admission charges were described and evaluated in total and by service provided. Among 1162 AKI patients, 57 patients (4.9%) died during the index admission (first admission during the study period), and among the survivors, 220 patients were re-hospitalized with a recurrent AKI during five years of follow-up. Patients with higher discharge serum creatinine level (SCr) at index admission had higher odds of AKI recurrence (OR = 1.001). Patients who were on respiratory, antineoplastic, or anticoagulant medications were also more susceptible to recurrence; ORs were 1.69, 2.77, and 4.16, respectively. Patients who were elderly, with recurrent AKI episodes, or with a more extended hospital stay at index admission were more likely to die during the five years post discharge. The median charge of recurrent admissions was higher than the median charge of the index admissions; 1519.17 JOD ($2142.7) versus 1362.85 JOD ($1922.2), respectively. Recurrent AKI is associated with increased mortality and health expenditures. Higher discharge SCr levels at index admission, and chronic comorbidities are associated with a higher likelihood of AKI recurrence.