cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.11350901
title: Polydatin protects H9c2 cells from hypoxia-induced injury via up-regulating long non-coding RNA DGCR5

description: Polydatin (PD), a monocrystalline polyphenolic drug mainly found in the roots of Polygonum cuspidatum, has various pharmacological activities. Long non-coding RNAs (lncRNA) DiGeorge syndrome critical region gene 5 (DGCR5) was found to participate in the suppression of multiple cancers. Here, we proposed to study the effect of PD on myocardial infarction (MI) by inducing DGCR5. CCK-8 assay was performed to detect the viability of H9c2 cells. Flow cytometry was utilized to test apoptosis of H9c2 cells. These results determined the optimal concentration and effect time of hypoxia as well as PD. Si-DGCR5 was transfected into cells and the expression level was determined by qRT-PCR. Western blot was utilized to evaluate the expression of apoptosis-related proteins, Bcl-2, Bax, and cleaved-caspase-3, as well as autophagy-associated proteins including Beclin-1, p62, and LC3-II/LC3-I. As a result, PD efficiently attenuated hypoxia-induced apoptosis and autophagy in H9c2 cells. The expression of DGCR5 was down-regulated by hypoxia and up-regulated by PD. Besides, knocking-down the expression of DGCR5 inhibited the protection of PD in H9c2 cells. In addition, PD up-regulated the accumulation of DGCR5, DGCR5 decreased the expression of Bcl-2 and p62, raised the expression of Bax and cleaved-caspase-3, and the proportion of LC3-II/LC3-I. PD stimulated the PI3K/AKT/mTOR and MEK/ERK signaling pathways via up-regulating the expression of DGCR5. Our data demonstrated that PD reduced cell apoptosis and autophagy induced by hypoxia in cardiomyocytes. Moreover, PD activated PI3K/AKT/mTOR and MEK/ERK signaling pathways by up-regulating the expression of DGCR5.
DOI: 10.6084/m9.figshare.11350904
title: Cleaning procedures applied to the conservation of terrazzo tiles from the early twentieth century

description: Abstract Terrazzo tiles are made of crushed mineral aggregate, cement (normal, white or pigmented) and sand. The mineral aggregate, called granitine, is responsible for the tiles' decorative appearance. The origin of its use in buildings in the city of Belem (Brazil) dates back to the start of imports of building materials during Brazilian industrialisation period. Terrazzo tiles are subject to weathering and human action, which cause several anomalies whose treatment depends on the tiles' constituents. The objective of this study is to evaluate the effectiveness of mechanical cleaning techniques using water and neutral soap, chemical bentonite patches and laser on terrazzo tile samples. After a visual analysis, the efficacy of the different methods was evaluated through brightness and colour measurements. The results showed that the laser cleaning yielded superior results, especially in the white, black and pink colours. However, the technique caused changes in the brightness of the tiles. The bentonite patch achieved satisfactory overall results, especially in the green colour, without causing changes in the brightness of the samples. This study aims to improve cleaning strategies so that, subsequently, the technique becomes feasible for other similar products, as well as for limestone and cement-based materials.
DOI: 10.6084/m9.figshare.11350907
title: From the “Paulista peasant” to the “Independence men”: interpretations under dispute over the national past in the Hall of Honor of Museu Paulista

description: ABSTRACT In this article we analyze the narrative transformation that took place in the Hall of Honor of the Museu Paulista, between 1895, year of its inauguration, and the celebration of the centenary of the Independence of Brazil, in 1922. We observed intellectual and political articulations of historical narrative nature based on the commission of paintings specially dedicated to that celebratory space of the founding of the nation, aiming to understand what reasons must have guided the rise process of a landmark of the Empire during the First Republic. Therefore, we address projects that have had discontinuity and deviations both from the political elite and intellectuals and painters.
DOI: 10.6084/m9.figshare.11350913.v1
title: The preservation effect and mechanism of gelatin on golden pompano (Trachinotus blochii) fillets during cold storage

description: Abstract The effect of different concentrations of gelatin (0%, 2.5%, and 5%) and vacuum packaged on the preservation of golden pompano (Trachinotus blochii) fillets stored at 4 °C was studied over 14 days. The results suggested that both the gelatin groups (2.5% and 5%) showed a reduction in deterioration of colour, drip loss and texture compared to the control group (0%). In addition, the gelatin coating caused a slower reduction in the freshness indexes of the fish, such as total volatile base nitrogen (TVB-N), thiobarbituric acid reactive substances (TBARS), total viable counts and pH. During a certain storage period, the gelatin notably prevented the deterioration of the golden pompano fillet at 4 °C. The 5% gelatin group showed the best effect on preserving the freshness indexes. Thus, the application of gelatin as a preservative is highly prospective for the preservation of fish fillets.
DOI: 10.6084/m9.figshare.11350904.v1
title: Cleaning procedures applied to the conservation of terrazzo tiles from the early twentieth century

description: Abstract Terrazzo tiles are made of crushed mineral aggregate, cement (normal, white or pigmented) and sand. The mineral aggregate, called granitine, is responsible for the tiles' decorative appearance. The origin of its use in buildings in the city of Belem (Brazil) dates back to the start of imports of building materials during Brazilian industrialisation period. Terrazzo tiles are subject to weathering and human action, which cause several anomalies whose treatment depends on the tiles' constituents. The objective of this study is to evaluate the effectiveness of mechanical cleaning techniques using water and neutral soap, chemical bentonite patches and laser on terrazzo tile samples. After a visual analysis, the efficacy of the different methods was evaluated through brightness and colour measurements. The results showed that the laser cleaning yielded superior results, especially in the white, black and pink colours. However, the technique caused changes in the brightness of the tiles. The bentonite patch achieved satisfactory overall results, especially in the green colour, without causing changes in the brightness of the samples. This study aims to improve cleaning strategies so that, subsequently, the technique becomes feasible for other similar products, as well as for limestone and cement-based materials.
DOI: 10.6084/m9.figshare.11350907.v1
title: From the “Paulista peasant” to the “Independence men”: interpretations under dispute over the national past in the Hall of Honor of Museu Paulista

description: ABSTRACT In this article we analyze the narrative transformation that took place in the Hall of Honor of the Museu Paulista, between 1895, year of its inauguration, and the celebration of the centenary of the Independence of Brazil, in 1922. We observed intellectual and political articulations of historical narrative nature based on the commission of paintings specially dedicated to that celebratory space of the founding of the nation, aiming to understand what reasons must have guided the rise process of a landmark of the Empire during the First Republic. Therefore, we address projects that have had discontinuity and deviations both from the political elite and intellectuals and painters.
DOI: 10.6084/m9.figshare.11350895
title: Effect of the addition of resistant starch in sausage with fat reduction on the physicochemical and sensory properties

description: Abstract Sausage is one of the meat products most consumed in Brazil, although the incorporation of fat is necessary for its elaboration, influencing its technological and sensory characteristics and its caloric value. The aim of this study was to evaluate the addition of resistant starch as a fat substitute in sausage on physicochemical properties and sensory acceptance. The analyses performed were the centesimal composition, emulsion stability, instrumental colour, texture profile analysis and sensorial acceptance. The resistant starch was evaluated for thermal properties, demonstrating that it required a high temperature for gelatinization, indicating that there was probably no gelatinisation of the starch in the cooking of the sausages. There was a significant difference between the treatments T1 and T2 with partial fat reduction and caloric value reduction. The study showed that the partial fat reduction positively influenced the reduction of caloric value, emulsion stability, colour parameters and texture profile analysis. All treatments were well accepted by the consumers. The incorporation of resistant starch in sausages did not influence the centesimal composition, texture profile analysis and sensory analysis, showing it to be a promising ingredient in the making of healthier meat products.
DOI: 10.6084/m9.figshare.11350901.v1
title: Polydatin protects H9c2 cells from hypoxia-induced injury via up-regulating long non-coding RNA DGCR5

description: Polydatin (PD), a monocrystalline polyphenolic drug mainly found in the roots of Polygonum cuspidatum, has various pharmacological activities. Long non-coding RNAs (lncRNA) DiGeorge syndrome critical region gene 5 (DGCR5) was found to participate in the suppression of multiple cancers. Here, we proposed to study the effect of PD on myocardial infarction (MI) by inducing DGCR5. CCK-8 assay was performed to detect the viability of H9c2 cells. Flow cytometry was utilized to test apoptosis of H9c2 cells. These results determined the optimal concentration and effect time of hypoxia as well as PD. Si-DGCR5 was transfected into cells and the expression level was determined by qRT-PCR. Western blot was utilized to evaluate the expression of apoptosis-related proteins, Bcl-2, Bax, and cleaved-caspase-3, as well as autophagy-associated proteins including Beclin-1, p62, and LC3-II/LC3-I. As a result, PD efficiently attenuated hypoxia-induced apoptosis and autophagy in H9c2 cells. The expression of DGCR5 was down-regulated by hypoxia and up-regulated by PD. Besides, knocking-down the expression of DGCR5 inhibited the protection of PD in H9c2 cells. In addition, PD up-regulated the accumulation of DGCR5, DGCR5 decreased the expression of Bcl-2 and p62, raised the expression of Bax and cleaved-caspase-3, and the proportion of LC3-II/LC3-I. PD stimulated the PI3K/AKT/mTOR and MEK/ERK signaling pathways via up-regulating the expression of DGCR5. Our data demonstrated that PD reduced cell apoptosis and autophagy induced by hypoxia in cardiomyocytes. Moreover, PD activated PI3K/AKT/mTOR and MEK/ERK signaling pathways by up-regulating the expression of DGCR5.
DOI: 10.6084/m9.figshare.11350892
title: Simulation of wheat yield by nitrogen and nonlinearity of environmental conditions

description: ABSTRACT Fuzzy logic can simulate wheat productivity by assisting crop predictability. The objective of the study is the use of fuzzy logic to simulate wheat yield in the conditions of nitrogen use, together with the effects of air temperature and rainfall, in the main cereal succession systems in Southern Brazil. The study was conducted in the years 2014, 2015 and 2016, in Augusto Pestana, RS, Brazil. The experimental design was a randomized block design with four repetitions in a 4 x 3 factorial scheme for N-fertilizer doses (0, 30, 60, 120 kg ha-1) and nutrient supply forms [100% in phenological stage V3 (third expanded leaf); (70%/30%) in the phenological stage V3/V6 (third and sixth expanded leaf) and; fractionated (70%/30%) at the phenological stage V3/E (third expanded leaf and beginning of grain filling)], respectively, in the soybean/wheat and corn/wheat systems. The pertinence functions and the linguistic values established for the input and output variables are adequate for the use of fuzzy logic. Fuzzy logic simulates wheat grain yield efficiently in the conditions of nitrogen use with air temperature and rainfall in crop systems.
DOI: 10.6084/m9.figshare.11350889
title: Spatial layouts and technical specifications for learning environments suitable for blended learning educational practices

description: Abstract The educational system in Brazil is undergoing a renewal process aimed at achieving international quality standards. This requires significant efforts to tackle the different problems public schools are faced with in Brazil, where physical infrastructure, human resources, pedagogical and digital resources should operate together. The modernisation of traditional educational strategies points to a tendency to implement a hybrid education system, through the insertion of Information and Communication Technologies (ICTs). This paper discusses the standard layouts of current learning environments and the development of new concepts, innovative building and technological aspects that may positively affect the ergonomic conditions of learning environments. This is a qualitative study, and the method adopted is based on a triangulation between Design Science Research and ergonomics methods to evaluate and design indoor school environments. The results point to the development of new spatial layouts for learning environments, with the application of flexibilities concepts for multiple learning activities, innovative formal solutions, ergonomic dimensional principles and technical specifications for spatial elements, systems and comfort conditions.
DOI: 10.6084/m9.figshare.11350895.v1
title: Effect of the addition of resistant starch in sausage with fat reduction on the physicochemical and sensory properties

description: Abstract Sausage is one of the meat products most consumed in Brazil, although the incorporation of fat is necessary for its elaboration, influencing its technological and sensory characteristics and its caloric value. The aim of this study was to evaluate the addition of resistant starch as a fat substitute in sausage on physicochemical properties and sensory acceptance. The analyses performed were the centesimal composition, emulsion stability, instrumental colour, texture profile analysis and sensorial acceptance. The resistant starch was evaluated for thermal properties, demonstrating that it required a high temperature for gelatinization, indicating that there was probably no gelatinisation of the starch in the cooking of the sausages. There was a significant difference between the treatments T1 and T2 with partial fat reduction and caloric value reduction. The study showed that the partial fat reduction positively influenced the reduction of caloric value, emulsion stability, colour parameters and texture profile analysis. All treatments were well accepted by the consumers. The incorporation of resistant starch in sausages did not influence the centesimal composition, texture profile analysis and sensory analysis, showing it to be a promising ingredient in the making of healthier meat products.
DOI: 10.6084/m9.figshare.11350889.v1
title: Spatial layouts and technical specifications for learning environments suitable for blended learning educational practices

description: Abstract The educational system in Brazil is undergoing a renewal process aimed at achieving international quality standards. This requires significant efforts to tackle the different problems public schools are faced with in Brazil, where physical infrastructure, human resources, pedagogical and digital resources should operate together. The modernisation of traditional educational strategies points to a tendency to implement a hybrid education system, through the insertion of Information and Communication Technologies (ICTs). This paper discusses the standard layouts of current learning environments and the development of new concepts, innovative building and technological aspects that may positively affect the ergonomic conditions of learning environments. This is a qualitative study, and the method adopted is based on a triangulation between Design Science Research and ergonomics methods to evaluate and design indoor school environments. The results point to the development of new spatial layouts for learning environments, with the application of flexibilities concepts for multiple learning activities, innovative formal solutions, ergonomic dimensional principles and technical specifications for spatial elements, systems and comfort conditions.
DOI: 10.6084/m9.figshare.11350892.v1
title: Simulation of wheat yield by nitrogen and nonlinearity of environmental conditions

description: ABSTRACT Fuzzy logic can simulate wheat productivity by assisting crop predictability. The objective of the study is the use of fuzzy logic to simulate wheat yield in the conditions of nitrogen use, together with the effects of air temperature and rainfall, in the main cereal succession systems in Southern Brazil. The study was conducted in the years 2014, 2015 and 2016, in Augusto Pestana, RS, Brazil. The experimental design was a randomized block design with four repetitions in a 4 x 3 factorial scheme for N-fertilizer doses (0, 30, 60, 120 kg ha-1) and nutrient supply forms [100% in phenological stage V3 (third expanded leaf); (70%/30%) in the phenological stage V3/V6 (third and sixth expanded leaf) and; fractionated (70%/30%) at the phenological stage V3/E (third expanded leaf and beginning of grain filling)], respectively, in the soybean/wheat and corn/wheat systems. The pertinence functions and the linguistic values established for the input and output variables are adequate for the use of fuzzy logic. Fuzzy logic simulates wheat grain yield efficiently in the conditions of nitrogen use with air temperature and rainfall in crop systems.
DOI: 10.6084/m9.figshare.11350877
title: Effect of storage on the bioactive compounds, nutritional composition and sensory acceptability of pitanga jams

description: Abstract Conventional and diet pitanga jams were prepared to assess the stability of bioactive compounds over 320 days of storage. The diet jam exhibited a higher nutritional value and bioactive compound content than the conventional jam. None of the tested jam formulations exhibited major changes in physical and nutritional characteristics during storage. However, the bioactive compound content and antioxidant activity were significantly reduced after processing pulp into jam and over the course of storage. Storage also had an effect on the sensory quality of the products. The conventional jam had higher flavour acceptance, whereas the diet jam exhibited lower scores for colour, appearance and overall acceptance.
DOI: 10.6084/m9.figshare.11350871
title: Morphology, Crystalline Structure and Chemical Composition Of MAO Treated Ti-15Zr-Mo Surfaces Enriched with Bioactive Ions

description: In this study, MAO treatment was used to enrich, with bioactive Ca, Mg and P atoms, as-casted and heat-treated Ti-15Zr-xMo (x = 0, 5, 10 and 15 wt%) alloys, for potential use as advanced metallic biomaterials. The chemical composition of the surface was evaluated by EDS and XPS measurements. The morphology and microstructure was analyzed by OM and SEM images. Crystalline structure and phase composition were characterized by XRD measurements. The results indicated that the oxide layers were porous, with microstructural features of the bulk (grain size and secondary phases) slightly affecting the surface characteristics (pore size, chemical and phase composition). The crystalline structure of the oxide layers were composed by a mixture of anatase and rutile phases (TiO2), with a minority of tetragonal zirconia (ZrO2) and traces of CaCO3 and P2O3 compounds. Chemical analysis indicated that the oxide layers were composed mainly by Ti and Zr oxides, with successful incorporation of the bioactive elements. The obtained results evidenced that the surface characteristics of MAO-treated Ti surfaces can be properly adjusted by the addition of alloying elements and implementation of specific heat treatments on the substrate. This finding can be quite useful for the development of novel biomedical implants.
DOI: 10.6084/m9.figshare.11350880
title: A HISTORICAL AND CONCEPTUAL OVERVIEW OF INTERDISCIPLINARY RESEARCH: AN ANALYSIS OF INTERDISCIPLINARY GRADUATE COURSES

description: ABSTRACT: This paper aims at tracing a brief historical reconstruction of interdisciplinary research in Brazil and its importance for the construction of knowledge. To this end, it adopts as a bibliographic and documentary research as methodological procedure, in order to understand interdisciplinary research in Brazil. Despite the article locus is Brazil, it is important to organize interdisciplinary knowledge worldwide in order to understand its trajectory in the country. The results indicate the main factors that hinder interdisciplinary research, as well as a way to guide actions that can mitigate such barriers and promote possibilities for advancement in the area because of an increasingly complex society.
DOI: 10.6084/m9.figshare.11350868
title: Drying and colour characteristics of Cleome gynandra L. (spider plant) leaves

description: Abstract Drying characteristics of Cleome leaves in an oven dryer was studied. The impact of oven drying temperature (50, 60 and 70 °C) on moisture composition of the plant at a uniform air speed was considered. Eight drying models, namely, simple exponential, Page, Verma, modified Henderson and Pabis, Lewis, two term exponential, Newton, logarithmic, and Wang and Singh were fitted to drying data. Modified Henderson and Pabis model satisfactorily depicts the drying behaviour of Cleome leaves. Effective moisture diffusivity of Cleome ranged from 1.03 × 10−6 to 1.77 × 10−5 m2/s. Reliance of the calculated effective diffusivity on oven temperature was unavoidable. The required activation energy for oven drying of Cleome leaves was found to be 24.46 kJ/mol. The colour characteristics of Cleome leaves in terms of L*, a* and b* were determined. Based on the colour characteristics results, drying condition of 70 °C 90 min was found to be optimum for oven drying of Cleome leaves.
DOI: 10.6084/m9.figshare.11350877.v1
title: Effect of storage on the bioactive compounds, nutritional composition and sensory acceptability of pitanga jams

description: Abstract Conventional and diet pitanga jams were prepared to assess the stability of bioactive compounds over 320 days of storage. The diet jam exhibited a higher nutritional value and bioactive compound content than the conventional jam. None of the tested jam formulations exhibited major changes in physical and nutritional characteristics during storage. However, the bioactive compound content and antioxidant activity were significantly reduced after processing pulp into jam and over the course of storage. Storage also had an effect on the sensory quality of the products. The conventional jam had higher flavour acceptance, whereas the diet jam exhibited lower scores for colour, appearance and overall acceptance.