cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.20455181.v1
title: Preparation of angiotensin I-converting enzyme (ACE) inhibitory peptides from Tie Guanyin tea residue protein using two-step enzymatic hydrolysis

description: Abstract In this study, we attempted to prepare novel angiotensin I-converting enzyme inhibitory (ACEI) peptides from Tie Guanyin tea residue protein (TTRP). Different proteases were used to hydrolyze TTRP to prepare ACEI peptides, neutral protease and alkaline protease hydrolysates exhibited higher ACEI activity and was chosen in further hydrolysis treatment. Response surface methodology (RSM) was used to optimize the enzymatic condition, and the results indicated that the optimal conditions of enzymatic hydrolysis were: 4% (w/v) of TTRP in water was hydrolyzed with 3500 U/g neutral protease at 50 °C and pH 6.5 for 2.5 h in the first step and then with 5000 U/g alkaline protease at 50 °C and pH 10.0 for 3 h in the second step. Under the optimum condition, the ACE inhibitory rate of the final products was 88.45% ± 0.45% at the concentration of 1.0 mg/mL. Moreover, ACEI peptides derived from TTRP showed good stability under different temperatures, pHs, metal ions and gastrointestinal digestion. These results indicated that the TTRP has potential to be used for preparing ACEI peptides.
DOI: 10.6084/m9.figshare.21257703
title: CAGE-seq clusters

description: Cluster count table from frontal CAGE-seq data of RiMod-FTD resource (https://www.rimod-ftd.org/). <br> The data was processed as follows: Sequencing adapters and barcodes in CAGE-seq FastQ files were trimmed using Skewer (v.0.1.126). Sequencing artefacts were removed using TagDust (v1.0)1 Processed reads were then aligned against the human genome hg38 using STAR (v.2.4.1). On average, 16,306,077 could be uniquely mapped per sample (76% uniquely mapped on average reads per sample). CAGE detected TSS (CTSS) files were created using CAGEr (v1.10.0). With CAGEr, we removed the first G nucleotide if it was a mismatch. CTSS were clustered using the ‘distclu’ method with a maximum distance of 20 bp. For exact commands used we refer to the reader to the scripts used in this pipeline: https://github.com/dznetubingen/cageseq-pipeline-mf. In total, we could identify 47,298 different peaks. Data was normalized to counts per million (CPM) for visualization on the website.
DOI: 10.6084/m9.figshare.21257694.v1
title: Methylation mValues

description: M-values of frontal methylation data from the RiMod-FTD resource (https://www.biorxiv.org/content/10.1101/2020.12.01.405894v4). <br> Data was processed as follows: <br> The Infinium MethylationEPIC BeadChip, which consists of 866,091 CpG locations, data was analyzed using the minfi R package. We removed all sites with a detection P-value above 0.01, on sex chromosomes and with single nucleotide polymorphisms (SNPs), leaving 810,290 loci for analysis. Data normalization was done using stratified quantile normalization. Sites with a standard deviation below 0.1 were considered uninformative and filtered out, leaving 170,595 sites that were used to perform a principal component analysis.
DOI: 10.6084/m9.figshare.21382770
title: Alopecia Universalis after Treatment with Simvastatin and Ezetimibe: Affects on Family

description: Abstract Alopecia areata (AA) is an autoimmune disease that grows in the scalp or in other parts of the body. Alopecia universalis, which is a rare form of alopecia areata, is characterized by a loss of hair that affects the entire body. In the two patients presented in this study, atorvastatin treatment was implemented, with the diagnosis of hypercholesterolemia; however, when the target values were not reached, a combination of simvastatin and ezetimibe was implemented. After a period of simvastatin/ezetimibe treatment, the AA disorder, which began with hair loss on the scalp, spread to the entire body and turned into Alopecia Universalis. Although statins can cause alopecia with autoimmune reactions, they are generally used in the treatment of alopecia due to their immunomodulatory effects.
DOI: 10.6084/m9.figshare.21382770.v1
title: Alopecia Universalis after Treatment with Simvastatin and Ezetimibe: Affects on Family

description: Abstract Alopecia areata (AA) is an autoimmune disease that grows in the scalp or in other parts of the body. Alopecia universalis, which is a rare form of alopecia areata, is characterized by a loss of hair that affects the entire body. In the two patients presented in this study, atorvastatin treatment was implemented, with the diagnosis of hypercholesterolemia; however, when the target values were not reached, a combination of simvastatin and ezetimibe was implemented. After a period of simvastatin/ezetimibe treatment, the AA disorder, which began with hair loss on the scalp, spread to the entire body and turned into Alopecia Universalis. Although statins can cause alopecia with autoimmune reactions, they are generally used in the treatment of alopecia due to their immunomodulatory effects.
DOI: 10.6084/m9.figshare.21257694
title: Methylation mValues

description: M-values of frontal methylation data from the RiMod-FTD resource (https://www.biorxiv.org/content/10.1101/2020.12.01.405894v4). <br> Data was processed as follows: <br> The Infinium MethylationEPIC BeadChip, which consists of 866,091 CpG locations, data was analyzed using the minfi R package. We removed all sites with a detection P-value above 0.01, on sex chromosomes and with single nucleotide polymorphisms (SNPs), leaving 810,290 loci for analysis. Data normalization was done using stratified quantile normalization. Sites with a standard deviation below 0.1 were considered uninformative and filtered out, leaving 170,595 sites that were used to perform a principal component analysis.
DOI: 10.6084/m9.figshare.21257691
title: smRNA-seq count table

description: Normalized count files of the frontal smRNA-seq dataset from the RiMod-FTD resource (https://www.biorxiv.org/content/10.1101/2020.12.01.405894v4). <br> The data was processed as follows: <br> After removing sequencing adapters, all FastQ files were uploaded to OASIS2 for analysis. On average, 3,430,613 (+/- 1,365,407) reads could be uniquely mapped per sample. Subsequent differential expression analysis was performed on the counts yielded from OASIS2, using DESeq2 and correcting for gender and PH-value, as was done for the RNA-seq data. Additionally, we added a batch variable to the design matrix to correct for the two different batches of this dataset. In total, 2904 human smRNA genes could be detected. For visualization and clustering, the data was transformed using the variance stabilization transformation from the DESeq2 package.
DOI: 10.57967/hf/0053
title: bengali-names-vs-gender
DOI: 10.6084/m9.figshare.21353195
title: Inequality in the middle of a crisis: an analysis of health workers during the COVID-19 pandemic from the profession, race, and gender perspectives

description: Abstract Studies show that people in vulnerable conditions and some social groups such as women and black people have suffered more intensely from the COVID-19 pandemic impacts. This expression of inequality also manifests itself among healthcare workers, with greater exposure of some specific groups. This paper analyzes the effect of COVID-19 on health care workers and the working conditions in the Brazilian public health system, analyzed from professional, gender, and race perspectives. Data were collected from an online survey of 1,829 health workers conducted in March 2021. Indeed, we identified inequalities in health workers’ experiences during the health crisis generated by COVID-19, which are marked by the profession of each worker and are traversed by their gender and race traits.
DOI: 10.6084/m9.figshare.21353195.v1
title: Inequality in the middle of a crisis: an analysis of health workers during the COVID-19 pandemic from the profession, race, and gender perspectives

description: Abstract Studies show that people in vulnerable conditions and some social groups such as women and black people have suffered more intensely from the COVID-19 pandemic impacts. This expression of inequality also manifests itself among healthcare workers, with greater exposure of some specific groups. This paper analyzes the effect of COVID-19 on health care workers and the working conditions in the Brazilian public health system, analyzed from professional, gender, and race perspectives. Data were collected from an online survey of 1,829 health workers conducted in March 2021. Indeed, we identified inequalities in health workers’ experiences during the health crisis generated by COVID-19, which are marked by the profession of each worker and are traversed by their gender and race traits.
DOI: 10.6084/m9.figshare.21382771
title: Foam Cells in Atherosclerosis
DOI: 10.6084/m9.figshare.21382771.v1
title: Foam Cells in Atherosclerosis
DOI: 10.6084/m9.figshare.21382774
title: Whey protein isolate and prebiotic biopolymers to stabilize pink-pepper oleoresin microcapsules

description: Abstract The objective of this work was to evaluate the use of whey protein isolate (WPI) associated with the prebiotic biopolymers inulin (IN) and oligofructose (OL) as a wall material on the physicochemical, morphological and thermal stability of pink-pepper oleoresin microcapsules. For spray drying in the treatments (WPI, WPI/IN, and WPI/OL), ultrasound-assisted emulsions were used, being prepared with 30% (w/w) wall material, 5% (w/w) oleoresin, and a 5:1 (w/w) replacement ratio for the WPI/IN and WPI/OL treatments. WPI increased the size of the oil droplets and of the reconstituted powder, which provided a greater encapsulation efficiency. The WPI and WPI/OL treatments showed a better antioxidant capacity, whereas WPI/IN and WPI/OL provided a better powder solubility. The microcapsules showed a spherical structure with some roughness, but no rupture, which favored the retention of oleoresin. Moreover, the microcapsule walls had no defined crystalline region. The addition of prebiotic biopolymers decreased the temperature at which the wall material started to degrade, decreasing its thermal stability. The use of WPI associated with inulin and oligofructose is suitable for the production of emulsions for the spray-drying microencapsulation of pink-pepper oleoresin.
DOI: 10.6084/m9.figshare.21382774.v1
title: Whey protein isolate and prebiotic biopolymers to stabilize pink-pepper oleoresin microcapsules

description: Abstract The objective of this work was to evaluate the use of whey protein isolate (WPI) associated with the prebiotic biopolymers inulin (IN) and oligofructose (OL) as a wall material on the physicochemical, morphological and thermal stability of pink-pepper oleoresin microcapsules. For spray drying in the treatments (WPI, WPI/IN, and WPI/OL), ultrasound-assisted emulsions were used, being prepared with 30% (w/w) wall material, 5% (w/w) oleoresin, and a 5:1 (w/w) replacement ratio for the WPI/IN and WPI/OL treatments. WPI increased the size of the oil droplets and of the reconstituted powder, which provided a greater encapsulation efficiency. The WPI and WPI/OL treatments showed a better antioxidant capacity, whereas WPI/IN and WPI/OL provided a better powder solubility. The microcapsules showed a spherical structure with some roughness, but no rupture, which favored the retention of oleoresin. Moreover, the microcapsule walls had no defined crystalline region. The addition of prebiotic biopolymers decreased the temperature at which the wall material started to degrade, decreasing its thermal stability. The use of WPI associated with inulin and oligofructose is suitable for the production of emulsions for the spray-drying microencapsulation of pink-pepper oleoresin.
DOI: 10.6084/m9.figshare.21382776
title: Seasonal variations in incidence of femoral fractures in the state of Rio Grande do Sul, southern Brazil

description: Abstract Introduction Femoral fractures are a major cause of morbidity and mortality, mainly among older people. Objective To examine the effect of seasonality on hospitalizations due to femur fracture among people residing in the Rio Grande do Sul state, southern Brazil, from 2008 to 2019. Methods Ecological study based on secondary data from the SUS Hospital Information System (SIH/SUS). A total of 74,374 reports of hospital admissions was considered. The generalized additive model (GAM) approach was employed to assess the seasonality of the time series, with stratification by sex and age groups and considering the monthly average number of events of femoral fractures per day as a dependent variable. Results A considerably higher incidence of femoral fractures in women aged 70 years or more was described. Among people aged less than 50 years, there is not an apparent seasonal effect. Men aged 70 years or older and women aged 50 years or older have a higher frequency of hospitalizations due to femur fractures in the colder months. Conclusion Among older people, more femoral fractures occurred during the winter compared to summer. This supports findings from other studies, although reasons for this seasonal variation are uncertain. The knowledge of these seasonal variations can help to plan the health care in the public health system.
DOI: 10.6084/m9.figshare.21382776.v1
title: Seasonal variations in incidence of femoral fractures in the state of Rio Grande do Sul, southern Brazil

description: Abstract Introduction Femoral fractures are a major cause of morbidity and mortality, mainly among older people. Objective To examine the effect of seasonality on hospitalizations due to femur fracture among people residing in the Rio Grande do Sul state, southern Brazil, from 2008 to 2019. Methods Ecological study based on secondary data from the SUS Hospital Information System (SIH/SUS). A total of 74,374 reports of hospital admissions was considered. The generalized additive model (GAM) approach was employed to assess the seasonality of the time series, with stratification by sex and age groups and considering the monthly average number of events of femoral fractures per day as a dependent variable. Results A considerably higher incidence of femoral fractures in women aged 70 years or more was described. Among people aged less than 50 years, there is not an apparent seasonal effect. Men aged 70 years or older and women aged 50 years or older have a higher frequency of hospitalizations due to femur fractures in the colder months. Conclusion Among older people, more femoral fractures occurred during the winter compared to summer. This supports findings from other studies, although reasons for this seasonal variation are uncertain. The knowledge of these seasonal variations can help to plan the health care in the public health system.
DOI: 10.6084/m9.figshare.21382777
title: “EMPODEREENF”: construction of an application for nurses’ continuing education on psychological violence against women

description: ABSTRACT Objective: to construct a prototype of a mobile application on psychological violence against women to facilitate nurses’ continuing education. Method: an applied methodological research of technological development, based on the Contextualized Instructional Design method. Results: the prototype content was based on the learning objectives developed through a narrative review, which guided an integrative review to compile the information. The prototype is called “EmpodereEnf”, and is composed of an initial screen, bringing nurses as a target audience, and, soon after, offering nine general moblets for access to information such as: concepts, causes, manifestations and consequences of psychological violence; means for identification and approach in nursing consultation and health education; compulsory notification and referral; examples of cases of psychological violence and references. Final considerations: the prototype is a possibility for future coping interventions and a work tool for nurses in the face of psychological violence against women.
DOI: 10.6084/m9.figshare.21382777.v1
title: “EMPODEREENF”: construction of an application for nurses’ continuing education on psychological violence against women

description: ABSTRACT Objective: to construct a prototype of a mobile application on psychological violence against women to facilitate nurses’ continuing education. Method: an applied methodological research of technological development, based on the Contextualized Instructional Design method. Results: the prototype content was based on the learning objectives developed through a narrative review, which guided an integrative review to compile the information. The prototype is called “EmpodereEnf”, and is composed of an initial screen, bringing nurses as a target audience, and, soon after, offering nine general moblets for access to information such as: concepts, causes, manifestations and consequences of psychological violence; means for identification and approach in nursing consultation and health education; compulsory notification and referral; examples of cases of psychological violence and references. Final considerations: the prototype is a possibility for future coping interventions and a work tool for nurses in the face of psychological violence against women.
DOI: 10.6084/m9.figshare.21382780
title: Corn silage quality under delayed sealing and microbial inoculant use

description: Abstract The objective of this work was to determine the effects of sealing delay for 12 hours and of the use of microbial inoculant with heterofermentative bacteria on whole-plant corn (Zea mays) silage. The experimental design was completely randomized in a 2×2 factorial arrangement (with or without inoculant × with or without sealing delay). Silage was evaluated for: chemical composition in vitro dry matter digestibility (IVDMD), fermentative parameters, losses, aerobic stability, and microbiological profile. The heating of the silage caused by respiration increased the contents of neutral detergent insoluble protein and of acid detergent insoluble protein by 77 and 27.3%, respectively. Soluble carbohydrate losses increased the contents of neutral detergent fiber corrected for ash and protein by 9.1% and of acid detergent fiber by 5.1%, but decreased the content of nonfibrous carbohydrates by 11.2%. IVDMD did not differ between treatments. Silages with delayed sealing and the inoculant showed higher pH and contents of acetic acid, propionic acid, and ammoniacal nitrogen, but a lower content of lactic acid. Delayed sealing reduces the nutritional value, increases the fibrous fractions, and decreases the soluble carbohydrates, whereas the use of inoculant does not improve the nutritional value and aerobic stability of the silages.
DOI: 10.6084/m9.figshare.21382780.v1
title: Corn silage quality under delayed sealing and microbial inoculant use

description: Abstract The objective of this work was to determine the effects of sealing delay for 12 hours and of the use of microbial inoculant with heterofermentative bacteria on whole-plant corn (Zea mays) silage. The experimental design was completely randomized in a 2×2 factorial arrangement (with or without inoculant × with or without sealing delay). Silage was evaluated for: chemical composition in vitro dry matter digestibility (IVDMD), fermentative parameters, losses, aerobic stability, and microbiological profile. The heating of the silage caused by respiration increased the contents of neutral detergent insoluble protein and of acid detergent insoluble protein by 77 and 27.3%, respectively. Soluble carbohydrate losses increased the contents of neutral detergent fiber corrected for ash and protein by 9.1% and of acid detergent fiber by 5.1%, but decreased the content of nonfibrous carbohydrates by 11.2%. IVDMD did not differ between treatments. Silages with delayed sealing and the inoculant showed higher pH and contents of acetic acid, propionic acid, and ammoniacal nitrogen, but a lower content of lactic acid. Delayed sealing reduces the nutritional value, increases the fibrous fractions, and decreases the soluble carbohydrates, whereas the use of inoculant does not improve the nutritional value and aerobic stability of the silages.
DOI: 10.6084/m9.figshare.21382785
title: Septal Ablation with Radiofrequency and the Use of New Technologies in Patients with Hypertrophic Cardiomyopathy in an Electrophysiology Laboratory
DOI: 10.6084/m9.figshare.21382785.v1
title: Septal Ablation with Radiofrequency and the Use of New Technologies in Patients with Hypertrophic Cardiomyopathy in an Electrophysiology Laboratory
DOI: 10.6084/m9.figshare.21382786
title: From Oríkì to Elinga: Black-Brazilian principles of acting and staging

description: ABSTRACT The purpose of this article is to present reflections that seek to system Black- Brazilian principles of dramatic performance and staging. The studies presented aim to demonstrate the need for theoretical-practical thinking in the performing arts focused on an anti-colonial perspective, as opposed to a hegemonic Euro-referenced vision. Thus, the concept of dramaturgy is problematized as part of a colonial device to control subjectivities. The theoretical-practical studies and the underlying arguments of this text were systematized with a basis in counter-hegemonic scenic experiments investigated in workshops, courses, and classes in which creative processes were developed, which do not separate the languages of dance, theater and performance.
DOI: 10.6084/m9.figshare.21382786.v1
title: From Oríkì to Elinga: Black-Brazilian principles of acting and staging

description: ABSTRACT The purpose of this article is to present reflections that seek to system Black- Brazilian principles of dramatic performance and staging. The studies presented aim to demonstrate the need for theoretical-practical thinking in the performing arts focused on an anti-colonial perspective, as opposed to a hegemonic Euro-referenced vision. Thus, the concept of dramaturgy is problematized as part of a colonial device to control subjectivities. The theoretical-practical studies and the underlying arguments of this text were systematized with a basis in counter-hegemonic scenic experiments investigated in workshops, courses, and classes in which creative processes were developed, which do not separate the languages of dance, theater and performance.
DOI: 10.6084/m9.figshare.21382841
title: Additional file 1 of A randomized feasibility pilot-study of intravenous and subcutaneous administration of ketamine to prevent postpartum depression after planned cesarean delivery under neuraxial anesthesia

description: Additional file 1.
DOI: 10.6084/m9.figshare.21382841.v1
title: Additional file 1 of A randomized feasibility pilot-study of intravenous and subcutaneous administration of ketamine to prevent postpartum depression after planned cesarean delivery under neuraxial anesthesia

description: Additional file 1.
DOI: 10.6084/m9.figshare.21382850
title: Additional file 2 of General control nonderepressible 1 interacts with cationic amino acid transporter 1 and affects Aedes aegypti fecundity

description: Additional file 2: Dataset S1. Excel workbook containing all yeast two-hybrid prey sequences from colonies with single prey plasmid copies. Each row represents the result from a single colony and includes the sequence of prey inserts generated from the T7 promoter in the pGAD-T7 prey plasmid.
DOI: 10.6084/m9.figshare.21382850.v1
title: Additional file 2 of General control nonderepressible 1 interacts with cationic amino acid transporter 1 and affects Aedes aegypti fecundity

description: Additional file 2: Dataset S1. Excel workbook containing all yeast two-hybrid prey sequences from colonies with single prey plasmid copies. Each row represents the result from a single colony and includes the sequence of prey inserts generated from the T7 promoter in the pGAD-T7 prey plasmid.
DOI: 10.6084/m9.figshare.21382865
title: Additional file 1 of Gossypetin ameliorates 5xFAD spatial learning and memory through enhanced phagocytosis against Aβ

description: Additional file 1. GOBP terms affected by gossypetin in 5xFAD. List of GOBP terms affected by gossypetin treatment in each 5xFAD microglial subpopulation.