cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.29900620
title: High-throughput assessment of <i>FMR1</i> and <i>SNRPN</i> methylation-based newborn screening using IsoPure and QIAcube HT systems

description: This study compared methylation-specific quantitative melt analysis of FMR1 and SNRPN methylation (mDNA) using automated bisulfite conversion by the magnetic-bead-based IsoPure and column-based QIAcube HT systems. Two bisulfite conversion methods were assessed on 3.2 mm punches from the same archival blood spots stored at room temperature for &gt;10 years of individuals with FMR1 premutation (<i>n</i> = 20), fragile X syndrome (FXS, <i>n</i> = 20), or chromosome 15 imprinting disorders (<i>n</i> = 50) and freshly made blood spots from 184 newborns from the general population. Performance criteria were: (i) diagnostic sensitivity and specificity for the conditions screened; (ii) reaction failure rate; (iii) variability in mDNA between groups. Both methods showed 100% sensitivity and specificity for differentiating FXS and individual chromosome 15 imprinting disorders. IsoPure showed reaction failure rates of 0.365% for SNRPN and 0.74% for FMR1 compared to 19.34% and 2.56%, for QIAcube HT, respectively, with most failed reactions originating from archival blood spots. IsoPure showed lower variability in mDNA values in the neurotypical and condition-specific ranges. The IsoPure system showed superior performance especially on archival samples, with broader applications for screening and diagnostic testing requiring high-throughput mDNA analyses on materials of limited quantity and quality. Testing for a change to DNA known as methylation has been used by researchers and in medical practice to identify people affected with different diseases. We compared how well two procedures that employ robotics, work in a lab. We tested a small amount of blood soaked onto absorbent cards to detect this change. Blood on these cards was from people who either had fragile X syndrome or a chromosome 15 imprinting disorder or did not have these. Both procedures worked equally well on freshly made materials in identifying these conditions without making any mistakes. One of the procedures, however, worked better, on cards not recently made. These results provide new opportunities for automated testing of DNA to detect diseases.
DOI: 10.6084/m9.figshare.29900620.v1
title: High-throughput assessment of <i>FMR1</i> and <i>SNRPN</i> methylation-based newborn screening using IsoPure and QIAcube HT systems

description: This study compared methylation-specific quantitative melt analysis of FMR1 and SNRPN methylation (mDNA) using automated bisulfite conversion by the magnetic-bead-based IsoPure and column-based QIAcube HT systems. Two bisulfite conversion methods were assessed on 3.2 mm punches from the same archival blood spots stored at room temperature for &gt;10 years of individuals with FMR1 premutation (<i>n</i> = 20), fragile X syndrome (FXS, <i>n</i> = 20), or chromosome 15 imprinting disorders (<i>n</i> = 50) and freshly made blood spots from 184 newborns from the general population. Performance criteria were: (i) diagnostic sensitivity and specificity for the conditions screened; (ii) reaction failure rate; (iii) variability in mDNA between groups. Both methods showed 100% sensitivity and specificity for differentiating FXS and individual chromosome 15 imprinting disorders. IsoPure showed reaction failure rates of 0.365% for SNRPN and 0.74% for FMR1 compared to 19.34% and 2.56%, for QIAcube HT, respectively, with most failed reactions originating from archival blood spots. IsoPure showed lower variability in mDNA values in the neurotypical and condition-specific ranges. The IsoPure system showed superior performance especially on archival samples, with broader applications for screening and diagnostic testing requiring high-throughput mDNA analyses on materials of limited quantity and quality. Testing for a change to DNA known as methylation has been used by researchers and in medical practice to identify people affected with different diseases. We compared how well two procedures that employ robotics, work in a lab. We tested a small amount of blood soaked onto absorbent cards to detect this change. Blood on these cards was from people who either had fragile X syndrome or a chromosome 15 imprinting disorder or did not have these. Both procedures worked equally well on freshly made materials in identifying these conditions without making any mistakes. One of the procedures, however, worked better, on cards not recently made. These results provide new opportunities for automated testing of DNA to detect diseases.
DOI: 10.6084/m9.figshare.29843352
title: DNA methylation associations with cognitive function in early-stage hormone receptor-positive breast cancer patients

description: Approximately one-third of breast cancer (BC) patients show poorer cognitive function (CF). Using DNA methylation (DNAm) data, here we aimed to identify genes and biological pathways associated with CF in postmenopausal women with early-stage hormone receptor-positive (HR+) BC. Epigenome-wide association studies (EWAS) and differentially methylated region analyses were performed for each CF phenotype (seven objective domains and one subjective phenotype) using DNAm data from whole blood samples (<i>n</i> = 109) taken at the time of enrollment. When adjusting for age, verbal IQ scores, and global DNAm signature, cg10331779 near <i>CTNND2</i> (p-value = 9.65×10−9) and cg25906741 in <i>MLIP</i> (p-value = 2.01×10−8) were associated with processing speed and subjective CF, respectively, while regions in/near <i>SLC6A11</i>, <i>PRKG1/CSTF2T</i>, and <i>FAM3B</i> for processing speed, and regions in/near <i>PI4KB</i> and <i>SGCE/PEG10</i> for mental flexibility were differentially methylated. In addition, beta-estradiol was identified as a common upstream regulator for all the CF phenotypes, suggesting an essential role of estrogen in explaining variation in CF of HR+ BC patients. In our EWAS of 8 CF phenotypes, we found two epigenome-wide significant signals, one for processing speed and the other for subjective CF. We also found three differentially methylated regions associated with processing speed and two associated with mental flexibility. www.clinicaltrials.gov identifier is NCT02793921. Many breast cancer patients experience problems remembering things, thinking clearly, or paying attention. Our study looked at how a chemical change called ‘DNA methylation’ – which controls how genes work without actually changing the genetic code itself – is related to these thought problems in 109 women with early-stage breast cancer. We found that methylation levels near the <i>CTNND2</i> gene were related to how quickly the brain processes information. Methylation levels near the <i>MLIP</i> gene were related to patients’ reports of their thought problems. We also discovered that beta-estradiol, a type of estrogen hormone, seemed to be a key player in all the thought problems we looked at. Our results give us new clues about why some breast cancer patients have thinking problems and point to other opportunities for future research.
DOI: 10.6084/m9.figshare.29843352.v1
title: DNA methylation associations with cognitive function in early-stage hormone receptor-positive breast cancer patients

description: Approximately one-third of breast cancer (BC) patients show poorer cognitive function (CF). Using DNA methylation (DNAm) data, here we aimed to identify genes and biological pathways associated with CF in postmenopausal women with early-stage hormone receptor-positive (HR+) BC. Epigenome-wide association studies (EWAS) and differentially methylated region analyses were performed for each CF phenotype (seven objective domains and one subjective phenotype) using DNAm data from whole blood samples (<i>n</i> = 109) taken at the time of enrollment. When adjusting for age, verbal IQ scores, and global DNAm signature, cg10331779 near <i>CTNND2</i> (p-value = 9.65×10−9) and cg25906741 in <i>MLIP</i> (p-value = 2.01×10−8) were associated with processing speed and subjective CF, respectively, while regions in/near <i>SLC6A11</i>, <i>PRKG1/CSTF2T</i>, and <i>FAM3B</i> for processing speed, and regions in/near <i>PI4KB</i> and <i>SGCE/PEG10</i> for mental flexibility were differentially methylated. In addition, beta-estradiol was identified as a common upstream regulator for all the CF phenotypes, suggesting an essential role of estrogen in explaining variation in CF of HR+ BC patients. In our EWAS of 8 CF phenotypes, we found two epigenome-wide significant signals, one for processing speed and the other for subjective CF. We also found three differentially methylated regions associated with processing speed and two associated with mental flexibility. www.clinicaltrials.gov identifier is NCT02793921. Many breast cancer patients experience problems remembering things, thinking clearly, or paying attention. Our study looked at how a chemical change called ‘DNA methylation’ – which controls how genes work without actually changing the genetic code itself – is related to these thought problems in 109 women with early-stage breast cancer. We found that methylation levels near the <i>CTNND2</i> gene were related to how quickly the brain processes information. Methylation levels near the <i>MLIP</i> gene were related to patients’ reports of their thought problems. We also discovered that beta-estradiol, a type of estrogen hormone, seemed to be a key player in all the thought problems we looked at. Our results give us new clues about why some breast cancer patients have thinking problems and point to other opportunities for future research.
DOI: 10.15468/dl.8s3sqc
title: Occurrence Download

description: A dataset containing 118 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Mustelus stevensi White & Last, 2008"
 ]
}

 The dataset includes 118 records from 9 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0001833-250424135625364/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.5281/zenodo.15282254
title: 3-color STED dataset of Reg3b, Tom20 and KDEL and associated colocalization analysis

description: 3-color STED imaging dataset of Reg3b, Tom20 and KDEL. The dataset was used for colocalization analysis between the Reg3b and Tom20; Reg3b and KDEL. The dataset was acquired as part of the manuscript "Reg3β controls an UPR mediated integrated stress response during therapy-induced oncofetal reprogramming in colorectal tumors".
DOI: 10.5281/zenodo.15282255
title: 3-color STED dataset of Reg3b, Tom20 and KDEL and associated colocalization analysis

description: 3-color STED imaging dataset of Reg3b, Tom20 and KDEL. The dataset was used for colocalization analysis between the Reg3b and Tom20; Reg3b and KDEL. The dataset was acquired as part of the manuscript "Reg3β controls an UPR mediated integrated stress response during therapy-induced oncofetal reprogramming in colorectal tumors".
DOI: 10.15468/dl.tzpc4z
title: Occurrence Download

description: A dataset containing 741 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Sandoricum koetjape (Burm.fil.) Merr.",
 "HasCoordinate is true",
 "BasisOfRecord is one of (Human Observation, Living Specimen, Occurrence evidence)"
 ]
}

 The dataset includes 741 records from 11 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0001835-250424135625364/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.q7k77f
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Maculinea arion",
 "Country is Germany",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 "Year is 1990"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0049786-250811113504898/datasets/export for details.
DOI: 10.15468/dl.et6j9h
title: Occurrence Download

description: A dataset containing 71 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Armadillidae",
 "Year 2011-2013",
 "Continent is Europe",
 "HasGeospatialIssue is false",
 "BasisOfRecord is one of (Machine Observation, Human Observation, Occurrence evidence, Observation)"
 ]
}

 The dataset includes 71 records from 9 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0049789-250811113504898/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.rq8hq9
title: Occurrence Download

description: A dataset containing 437 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Torreya grandis"
 ]
}

 The dataset includes 437 records from 39 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0049788-250811113504898/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.k54eur
title: Occurrence Download

description: A dataset containing 213 species occurrences available in GBIF matching the query:
{
 "and" : [
 "DatasetKey is Natuurmuseum Brabant, Tilburg - Observations",
 "Issue is Taxon match fuzzy"
 ]
}

 The dataset includes 213 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0017150-250525065834625/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.schxgw
title: Occurrence Download

description: A dataset containing 297 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Hugonia jenkinsii",
 "HasCoordinate is true",
 "BasisOfRecord is one of (Specimen)"
 ]
}

 The dataset includes 297 records from 17 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0004134-260129131611470/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.13140/rg.2.2.26502.23367/3
title: Chemical treatment of chocolate industry wastewater using purified cattle bone waste-derived biohydroxyapatite
DOI: 10.15468/dl.zu22gn
title: Occurrence Download

description: A dataset containing 3242 species occurrences available in GBIF matching the query:
{
 "DatasetKey" : [
 "is Micro- and nannoplankton in Belgian coastal waters near Nieuwpoort between 1970 and 1972"
 ]
}

 The dataset includes 3242 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0004135-260129131611470/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.6j787c
title: Occurrence Download

description: A dataset containing 27433 species occurrences available in GBIF matching the query:
{
 "and" : [
 "BasisOfRecord is Human Observation",
 "Country is one of (Dominican Republic, Haiti)",
 "TaxonKey is Dulus dominicus"
 ]
}

 The dataset includes 27433 records from 6 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0004137-260129131611470/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.xtbjmq
title: Occurrence Download

description: A dataset containing 478 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Corynorhinus rafinesquii",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 {
 "not" : {
 "BasisOfRecord" : [
 "is one of (Fossil)"
 ]
 }
 }
 ]
}

 The dataset includes 478 records from 32 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0004139-260129131611470/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.cf9v9a
title: Occurrence Download

description: A dataset containing 3 species occurrences available in GBIF matching the query:
{
 "and" : [
 "DatasetKey is Rafflesia verrucosa (Rafflesiaceae), a new species of small-flowered Rafflesia from eastern Mindanao, Philippines",
 "Year 2000-2026"
 ]
}

 The dataset includes 3 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0004141-260129131611470/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.pvx3vh
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Linum drymarioides",
 "HasCoordinate is true",
 "BasisOfRecord is one of (Specimen)"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0004142-260129131611470/datasets/export for details.
DOI: 10.15468/dl.r5xk7x
title: Occurrence Download

description: A dataset containing 20311 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Eptesicus fuscus",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 {
 "not" : {
 "BasisOfRecord" : [
 "is one of (Fossil)"
 ]
 }
 }
 ]
}

 The dataset includes 20311 records from 165 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0004144-260129131611470/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.j4kws4
title: Occurrence Download

description: A dataset containing 244 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Linum grandiflorum",
 "HasCoordinate is true",
 "BasisOfRecord is one of (Specimen)"
 ]
}

 The dataset includes 244 records from 80 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0004145-260129131611470/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.34740/kaggle/dsv/14693388
title: Peer-to-Peer Boliviano (BOB) Exchange Data
DOI: 10.34740/kaggle/dsv/14693375
title: Daily Market Prices of Commodity India (2001-2026)
DOI: 10.15468/dl.stnugy
title: Occurrence Download

description: A dataset containing 47600 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Hypsugo savii",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 {
 "not" : {
 "BasisOfRecord" : [
 "is one of (Fossil)"
 ]
 }
 }
 ]
}

 The dataset includes 47600 records from 956 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0004147-260129131611470/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.qjfhw7
title: Occurrence Download

description: A dataset containing 1200 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Linum tenuifolium",
 "HasCoordinate is true",
 "BasisOfRecord is one of (Specimen)"
 ]
}

 The dataset includes 1200 records from 96 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0004148-260129131611470/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.zmahme
title: Occurrence Download

description: A dataset containing 38 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Ia io",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 {
 "not" : {
 "BasisOfRecord" : [
 "is one of (Fossil)"
 ]
 }
 }
 ]
}

 The dataset includes 38 records from 11 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0004150-260129131611470/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.w2hbe2
title: Occurrence Download

description: A dataset containing 483 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Roucheria columbiana",
 "HasCoordinate is true",
 "BasisOfRecord is one of (Specimen)"
 ]
}

 The dataset includes 483 records from 49 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0004152-260129131611470/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.kgfc3z
title: Occurrence Download

description: A dataset containing 155 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Murina hilgendorfi",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 {
 "not" : {
 "BasisOfRecord" : [
 "is one of (Fossil)"
 ]
 }
 }
 ]
}

 The dataset includes 155 records from 8 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0004153-260129131611470/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.5281/zenodo.18446501
title: Assimilation of topographic and bathymetric data Layer 3_Res-1 arc-second

description: Assimilation of topographic and bathymetric data Layer 3_Res-1 arc-second in Flores area
DOI: 10.5281/zenodo.18446502
title: Assimilation of topographic and bathymetric data Layer 3_Res-1 arc-second

description: Assimilation of topographic and bathymetric data Layer 3_Res-1 arc-second in Flores area
DOI: 10.15468/dl.6z7e2u
title: Occurrence Download

description: A dataset containing 263 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Tirpitzia sinensis",
 "HasCoordinate is true",
 "BasisOfRecord is one of (Specimen)"
 ]
}

 The dataset includes 263 records from 16 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0004155-260129131611470/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.ycmtqj
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is ",
 "BasisOfRecord is one of (Specimen, Human Observation, Observation, Living Specimen, Machine Observation, Literature Occurrence)",
 "HasCoordinate is TRUE",
 "HasGeospatialIssue is FALSE"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0024979-250811113504898/datasets/export for details.
DOI: 10.15468/dl.44hbqv
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is ",
 "BasisOfRecord is one of (Specimen, Human Observation, Observation, Living Specimen, Machine Observation, Literature Occurrence)",
 "HasCoordinate is TRUE",
 "HasGeospatialIssue is FALSE"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0024978-250811113504898/datasets/export for details.
DOI: 10.34740/kaggle/dsv/12011371
title: Peer-to-Peer Boliviano (BOB) Exchange Data
DOI: 10.15468/dl.neff4n
title: Occurrence Download

description: A dataset containing 138146137 species occurrences available in GBIF matching the query:
{
 "DatasetKey" : [
 "is iNaturalist Research-grade Observations"
 ]
}

 The dataset includes 138146137 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0011696-260120142942310/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.