cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.20350/digitalcsic/13931
title: Dataset related to article: Simultaneous determination of six antipsychotics, two of their metabolites and caffeine in human plasma by LC-MS/MS using a phospholipid-removal microelution-solid phase extraction method for sample preparation

description: File 1. This xls files shows the data related to the main charateristics used for the development and validation of the new method as long as the measures for letting assure the repeatability and intermediate precision and accuracy values. The results obtained for the pharmacokinetic parameters are also included in the file File 2 This jpg file shows the product ion spectra and chemical structures of the antipsychotics and their metabolites obtained by collision-induced dissociation (CID) of the indicated precursor ions [M+H]+. The fragmentation patterns of all analytes are indicated by an arrow on their chemical structure of each analyte. The results are presented as the percentage of counts versus Mass-to-Charge (m/z). All mass peaks have been normalized to the most abundant
description: A simple and sensitive liquid chromatography-tandem mass spectrometry method was developed and validated in human plasma for the simultaneous determination of aripiprazole (ARI) and its metabolite dehydro-aripiprazole (DARI); olanzapine (OLA), risperidone (RIS), paliperidone (PAL), quetiapine (QUE), clozapine (CLO) and caffeine (CAF). CAF is included to the method because it can have an influence on drug metabolism due to competitive inhibition. The above mentioned compounds and their isotope-labeled internal standards were extracted from 200 µL human plasma samples by both, effective phospholipids-eliminating three-step microelution-solid-phase extraction (µ-SPE) and protein precipitation (PPT) for comparison. A combination of formic acid (0.2%)-acetonitrile (pH 3.0; 65:35, v/v) was used as mobile phase and the chromatogram was run under gradient conditions at a flow rate of 0.6 mL/min. Run time lasted 6 min, followed by a re-equilibration time of 3 min. All analytes were monitored by mass spectrometric detection operating in multiple reaction monitoring mode and the method was validated covering the corresponding therapeutic ranges: 0.18-120 ng/mL for ARI, 0.25-80 ng/mL for DARI, 1.00-100 ng/mL for OLA, 0.70-60 ng/mL for RIS, 0.20-30 ng/mL for PAL, 0.50-160 ng/mL for QUE, 0.50-1000 ng/mL for CLO, and finally 1200-3700 ng/mL for CAF. The method was validated based on the recommendations of regulatory agencies through tests of precision, accuracy, extraction recovery, identity confirmation, trueness, matrix effect, process efficiency, stability, selectivity, linearity and carry-over effect fulfilling the guideline requirements. Our µ-SPE method results in the elimination of more than 99% of early eluting and more than 92% of late-eluting phospholipids compared to PPT. Additionally, the method was successfully applied for quantifying ARI and OLA plasma concentrations from healthy volunteers.
DOI: 10.20350/digitalcsic/13929
title: Dataset related to article: Safety and cardiovascular effects of multiple-dose administration of aripiprazole and olanzapine in a randomised clinical trial

description: [Adverse Drug Reactions and CT] The xls file shows relevant information about the treatment with aripiprazole and olanzapine, as well as about their possible adverse effects and the frequency with which they occur. [Genotypes] This is a doc files where It is showm the genotype and phenotype frequencies of the analysed polymorphisms
description: [Objective] To assess adverse events (AEs) and safety of aripiprazole (ARI) and olanzapine (OLA) treatment. [Conclusions] OLA induced more cardiovascular changes; however, more ADRs were registered to ARI. In addition, some polymorphisms may explain the difference in the incidence of these effects among subjects.
DOI: 10.20350/digitalcsic/13927
title: Dataset related to article: Estimating pentose phosphate pathway activity from the analysis of hepatic glycogen 13C-isotopomers derived from [U-13C]fructose and [U-13C]glucose

description: Folder 1. Raw 13C NMR data for the liver glycogen samples. Folder names with CTL refer to mice fed standard chow, folder names with HS1 refer to mice given sugar supplements with U-13C-glucose and folder names with HS2 refer to mice given sugar enriched with U-13C-fructose. These data can be opened and processed by widely available NMR processing software such as ACD labs, Mestre Nova and NUTS. Folder 2. Spreadsheets for the NMR signal areas measured from the 13C NMR spectra and estimation of PPP fluxes from these signal areas
description: Hepatic PPP fluxes from both [U-13C] glucose and [U-13C]fructose precursors were assessed by 13C NMR analysis of glycogen 13C isotopomers Glucose-6-phosphate generated via glucokinase and the direct pathwayis preferentially utilized by PPP.
DOI: 10.20350/digitalcsic/13928
title: Transects and vertical profiles of PMx aerosols in Santo Antão and São Vicente, Cape Verde, in October 2019 - dataset

description: This file contains data of atmospheric aerosols particulate matter smaller than 10, 2.5 and 1 micron (PM10, PM2.5 and PM1) measured: -in vertical profiles, in sheets P1 to P3, -transects T1 to T3, -in ambient air at Porto Novo, Cova de Paul and Ribeira Grande each sheet contains the time, hour, latitude, longitude, temperature and humidity. Details on the methods used is described in: Sergio Rodríguez & Jessica López-Darias. Dust and tropical PMx aerosols in Cape Verde: sources, vertical distribution and stratified transport from North Africa. Atmospheric Research, 2021. DOI: xxx
description: This file contains data of aerosol PMx concentrations measured in Cape Verde (islands of Santo Antão and São Vicente) in October 2019 in the frame of the project VARDUSTSAL (PGC2018-099166-B-100; IP: Sergio Rodríguez) funded by the State Research Agency, the Ministry of Science, Innovation and Universities of Spain and the European Regional Development Fund. Data of vertical distributions and transfects of PMx near sources and in ambient air (including remote conditinos) are reported. Details are provided in Rodríguez & López-Darias (2021).
DOI: 10.20350/digitalcsic/13926
title: Dataset related to article: Determining the contribution of a high-fructose corn syrup formulation to hepatic glycogen synthesis during ad-libitum feeding in mice

description: Folder 1. Raw 1H and 2H NMR data for the liver glycogen samples. Folder names with CTL refer to mice fed standard chow, folder names with HS1 refer to mice given sugar supplements with U-13C-glucose and folder names with HS2 refer to mice given sugar enriched with U-13C-fructose. These data can be opened and processed by widely available NMR processing software such as ACD labs, Mestre Nova and NUTS. Folder 2. Raw 1H and 13C NMR data for the liver glycogen samples. Folder names with CTL refer to mice fed standard chow, folder names with HS1 refer to mice given sugar supplements with U-13C-glucose and folder names with HS2 refer to mice given sugar enriched with U-13C-fructose. These data can be opened and processed by widely available NMR processing software such as ACD labs, Mestre Nova and NUTS. Folder 3. Spreadsheets for the NMR signal areas measured from the 2H NMR spectra and estimation of glycogen synthesis sources from direct and indirect pathways based on these data (Excel 1) and the NMR signals measured from the 13C NMR spectra and estimation of the contributions of [U-13C]glucose and [U-13C]fructose to glycogen synthesis (Excel 2).
description: Excessive sugar intake including high-fructose corn syrup (HFCS) is implicated in the rise of obesity, insulin resistance and non-alcoholic fatty liver disease. Liver glycogen synthesis is influenced by both fructose and insulin signaling. Therefore, the effect of HFCS on hepatic glycogenesis was evaluated in mice feeding ad-libitum. Using deuterated water: the fraction of glycogen derived from triose-P sources, Krebs cycle substrates, and direct pathway + cycling, was measured in 9 normal-chow fed mice (NC) and 12 mice fed normal chow plus a 55% fructose/45% glucose mix in the drinking water at 30% w/v (HFCS-55). This was enriched with [U-13C]fructose or [U-13C]glucose to determine the contribution of each to glycogenesis. For NC, direct pathway + cycling, Krebs cycle, and triose-P sources accounted for 66 ± 0.7%, 23 ± 0.8% and 11 ± 0.4% of glycogen synthesis, respectively. HFCS-55 mice had similar direct pathway + cycling (64 ± 1%) but lower Krebs cycle (12 ± 1%, p
DOI: 10.20350/digitalcsic/13920
title: Physalia physalis abundance on the shores in the Mediterranean Sea during 2010, 2013 and 2018 compiled by ICMAN (CSIC)

description: The database provides Physalia physalis abundance on the shores of the Mediterranean Sea. The dataset is provided as [space] delimitated plain text file within a compressed folder that also includes a single README file (in text format) containing a detailed description of the data structure. For more details, see the publication: Macias, D., Prieto, L., Garcia-Gorriz, E., 2021. A model-based management tool to predict the spread of Physalia physalis in the Mediterranean Sea. Minimizing risks for coastal activities. Oceanography and Coastal Management (accepted).
description: [General Notes] The data are provided under an Attribution-ShareAlike 4.0 International license. However, if you use the data, so as to support the authors, please consider citing the above mentioned article where data collection and analytical techniques are given in detail. Here we only give a brief details and a guide to the contents of the data files. Data files are in UTF8 encoding, plain text format with space used as the delimiter. One column is written for each measured parameter. The order of each column is: Day, Month, Year, Number of colonies stranded, Latitude, Longitude and Julian Day. Missing data are filled with NaN.
description: [Geographical coordinates of the sampling area] coordinates.txt provides the geographical coordinates of the sampling area. ST.ID represents the code (used to link to other data tables) for each site. long and lat are longitude and latitude, respectively.
description: The dataset is subject to a Creative Commons License Attribution-ShareAlike 4.0 International.
description: This data set includes data collected from ICMAN-CSIC (Spain) during three years of high abundance of these colonies in the Mediterranean basin: 2010, 2013 and 2018 that have been used to build a prognosis tool (model) for the Mediterranean Sea.
DOI: 10.20350/digitalcsic/13924
title: Dataset related to article: Human macrophages stimulate expression of inflammatory mediators in adipocytes; effects of second-generation antipsychotics and glucocorticoids on cellular cross-talk

description: Direct effects of SGAs on macrophage-adipocyte communication. The xls file shows the raw data obtained from the measurement of gene expression from the isolated human mature adipocytes co-cultured with THP-1 derived macrophages pre-treated with ARI, OLA, and dehydroaripiprazole (dARI) and gene expression in macrophages treated with ARI, OLA and dARI during and after their polarisation.
description: Macrophages induce expression of pro-inflammatory genes in human subcutaneous adipocytes without affecting the expression of adipokines or genes involved in energy regulation SGAs and dexamethasone had a mild effect on macrophage-adipocyte communication in M1 macrophage phenotype
DOI: 10.20350/digitalcsic/13922
title: Dataset related to article: Effects of second-generation antipsychotics on human subcutaneous adipose tissue metabolism

description: Analysis of the direct effects of SGAs on adipose tissue metabolism and gene expression. The xls file shows the raw data of adipocyte glucose uptake lipolysis after short-term (30 min) and long term (24 and 72h) incubation of adipocytes and adipose tissuewith therapeutic and supra-therapeutic concentration of olanzapine (Ola) and Aripripazole (Ari).
description: Therapeutic concentrations of olanzapine and aripripazole have a moderate direct effect and adipocyte lipid and glucose metabolism, respectively. At supra-therapeutic concentrations, both of the antipsychotics seem to act as anti-inflammatory agents and mildly suppressed genes involved in the regulationof mitochondrial functions, which could potentially contribute to metabolic adverse effects. Alternatively, second generation antipsychotics could induce metabolic side effects via acting on other insulin-sensitive tissues and central nervous system.
DOI: 10.20350/digitalcsic/13869
title: Dataset: Individual differences in responsiveness to diet-induced milk fat depression in dairy sheep and goats
DOI: 10.20350/digitalcsic/13914
title: G6PD overexpression protects from oxidative stress and age-related hearing loss [Dataset]

description: zip file containing 6 folders Bioanalyzer folder; Figure 1 folder [Figure1_qPCR.xlsx; Figure1_ABR.xlsx; Figure1_ Amplitudes_SPSS.pdf; Figure1_Audiogram_SPSS.pdf; Figure1_ Latencies_SPSS.pdf; Figure1_MyeP0 IHQ base.txt; Figure1_MyeP0 IHQ middle.txt; Figure1_MyeP0 IHQ quantification.xlsx]; Figure 2 folder [Figure2_CtBP2GluR2/3_ whole mount_quantification.xlsx; Figure2_Hair cells counts whole mount_quantification.xlsx; Figure2_Neurofilament number of fibers_quantification; Figure2_Neurofilament Intensity OHC_quantification.xlsx]; Figure 3 folder [Figure3_Western Blot_quantification analysis.xlsx; Exp0_p22phox Mb2 20170608_1327 Prec8sectif_AllLanes.pdf; Exp0_PI3K Mb2 20170608_1500 Prec8sectif_AllLanes.pdf; Exp1_p22phox_Mb4_20180222_1340_Prec2sec_tapandotif_AllLanes.pdf; Exp1_PI3K_Mb4_20180216_1446_Prec4sectif_AllLanes.pdf; Figure3_3NT IHQ quantification intensity; Figure3_Cyt C Oxidase IHF quantification intensity.xlsx; Figure3_qPCR Source Data.xlsx]; Figure 4 folder [Figure4_Western Blot_quantification analysis.xlsx; Figure4_Western Blot_ImageQuant; Figure4_TUNEL+ whole mount_quantification.xlsx]; Figure 5 folder [Figure5_qPCR .xlsx; Figure5_IBA1 IHF quantification].
DOI: 10.20350/digitalcsic/13862
title: Dataset: Effect of lipid supplementation on the endogenous synthesis of milk cis-9 trans-11 CLA in dairy sheep and goats
DOI: 10.20350/digitalcsic/13826
title: Meteorological dataset "Spatial Distribution of Factors Controlling Stable Isotopes in Precipitation in Northern Chile"

description: S_1_Meteorological data: This study reports daily meteorological data from 131 automatic weather stations belonging to the General Directorate of Waters (Center for Climate and Resilience Research, 2020; DGA, 2020) of Chile and Soquimich (SQM). The weather stations are located at elevations ranging from 1900 to 5100 m a.s.l.
description: The data is a compilation of information from previous studies and during the study published in “Spatial Distribution of Factors Controlling Stable Isotopes in Precipitation in Northern Chile”.
DOI: 10.20350/digitalcsic/13827
title: Isotope dataset "Spatial Distribution of Factors Controlling Stable Isotopes in Precipitation in Northern Chile"

description: S_2_Isotope data: In the Salar de Atacama study, 5 Palmex passive precipitation samplers (Gröning et al., 2012) were installed at different sites in the Salar de Atacama basin to support this study. Samples were collected in 30 mL polyethylene bottles. Seventeen accumulated rainwater samples of various rainwater events were obtained in the period 2017-2019. All these samples were analysed for δ18O and δ2H at the University of Waterloo-Environmental Isotope Laboratory (uwEILAB) using a Los Gatos Research Off-Axis Integrated Cavity Output Spectroscopy (LGR-OA-ICOS) Laser System. The analytical uncertainty is ±0.2‰ for δ18O and ±0.8‰ for δ2H. Additionally, isotopic data in the study area from previously published studies were included in this analysis (Alpers and Whittemore, 1990; Aravena et al., 1999, 1989; Cortecci et al., 2005; CRICYT, 2017; Fritz et al., 1981; Godfrey et al., 2019; Herrera et al., 2016, 2006; Lagos, 2016; López et al., 2016; Moran et al., 2019; Uribe et al., 2015). The dataset consists of 300 isotope analyses in the 1973-2017 period for rain and snow samples accumulated daily or monthly. The water isotope standard is the Mean Ocean Water: Standard Mean Ocean Water (SMOW) and Vienna Standard Mean Ocean Water (VSMOW).
description: The data is a compilation of information from previous studies and during the study published in “Spatial Distribution of Factors Controlling Stable Isotopes in Precipitation in Northern Chile”.
DOI: 10.20350/digitalcsic/13780
title: Organic carbon and environmental DNA in Eastern Mediterranean seagrass sediments

description: Data on biogeochemical characteristics (210Pb geochronologies, density, organic matter, organic carbon concentration, stable carbon isotopes, carbon stocks and carbon burial rates) and on the detection of Halophila stipulacea with eDNA in seagrass sediments cores from H. stipulacea, Cymodocea nodosa and Posidonia oceanica meadows collected in the Eastern Mediterranean (Greece and Cyprus).
DOI: 10.20350/digitalcsic/13728
title: Experimental data files of manuscript Protein biomarkers of bovine defective meats at a Glance: Gel-Free Hybrid Quadrupole-Orbitrap Analysis for Rapid Screening

description: The dataset is made available under the Open Database License. Any rights in individual contents of the database are licensed under the Database Contents License. Please, read the full ODbL 1.0 license text for the exact terms that apply. Users of the dataset are free to: Share: copy, distribute and use the database, either commercially or non-commercially. Create: produce derivative works from the database. Adapt: modify, transform and build upon the database. Under the following conditions: Attribution: You must attribute any public use of the database, or works produced from the database. For any use or redistribution of the database, or works produced from it, you must make clear to others the license of the original database. Share-Alike: If you publicly use any adapted version of this database, or works produced from an adapted database, you must also offer that adapted database under the ODbL.
description: List of experimental data: A-Original Thermo .RAW datafiles merging full-MS1 and ddMS2 analyses -QexDFDhesiOFF.RAW -QexNORMALhesiOFF.RAW B-Mascot Generic Format (.mgf) files from ddMS2 data -QexDFDhesiOFF.mgf -QexNORMALhesiOFF.mgf
DOI: 10.20350/digitalcsic/13682
title: Aggressiveness-related behavioural types in the pearly razorfish [dataset]

description: Los datos fueron generados manualmente a través de la visualización de videos de los experimentos. Fueron introducidos en RStudio Team (2020), donde se analizaron para la obtención de los resultados.-- este conjunto de datos es original de este trabajo. No se ha usado datos de estudios preliminares.-- Datos recogidos en experimentos realizados en el Laboratorio de Investigaciones Marinas y Acuicultura (LIMIA) en Mallorca. Los individuos experimentales fueron capturados en la Bahía de Palma, Mallorca.
description: This data set is supplementary material for the article "Types of behaviour related to aggressiveness in pearlescent fish". Animal personality has a very relevant implication in a multitude of eco-evolutionary processes. It is a topic very approached in freshwater fish, not so in marine species, because its captivity is a challenge to reproduce its natural habitat. this is the first evidence of behavioural traits in the pearly razorfish. For this, we designed experiments in the laboratory, where the experimental individuals were subjected to the mirror test—a widely used test to determine each individual's aggressiveness. By not recognizing their reflection in the mirror, fish perceive their reflection as the intrusion of another individual into their territory. Thanks to these experiments, we were able to determine each individual's aggressiveness score, finding significant differences between individuals. Differences found regardless of height, sex or individual condition. These findings suggest that this species' aggressiveness may have a genetic origin, as has been demonstrated in other species.
DOI: 10.20350/digitalcsic/13748
title: Natural vs. trawling-induced water turbidity and sediment transport variability within the Palamós Canyon (NW Mediterranean) [Dataset]

description: Data of hydrographic properties (pressure, temperature, salinity and turbidity) collected by an autonomous hydrographic profiler deployed in the axis of the Palamós Canyon (NW Mediterranean), and near-bottom time series of turbidity and currents. Additionally, data (temperature, salinity and turbidity) collected during an hydrographic CTD transect across the Palamós Canyon's head is also provided
description: Submarine canyons are considered preferential pathways for the effective off-shelf transport of suspended particulate matter across continental margins, between coastal areas and deep-sea environments. Increases of water turbidity and sediment transport in submarine canyons have been associated with natural oceanographic events such as internal waves, storms or dense shelf water cascading (DSWC), and occasionally with anthropogenic activities such as deep-sea bottom trawling along canyon flanks and rims. To assess the variations on the sedimentary dynamics in the Palamós Canyon linked to both natural and trawling-induced processes, an autonomous hydrographic profiler, as well as a near-bottom current meter and a turbidimeter were deployed in the canyon axis (929 m depth) from February to June 2017. The mooring line was located between the two trawling grounds present on each canyon flank, and the recording period covered a trawling closure period (February) and the re-commencement of the regular trawling season (March-June). Periods of enhanced water turbidity during the trawling closure were mostly associated with storms and DSWC events, causing the arrival of turbid dense waters into the canyon. Subsequently, the water column displayed low background suspended sediment concentrations (~ 0.3 mg L-1) until the trawling season began, which was characterized by the presence of particulate matter detachments observed mainly at the water depths were the trawling grounds are found. During the trawling closure, high near-bottom instantaneous suspended sediment fluxes (35-44 g m-2 s-1) were sporadically registered associated with storms and DSWC events. In contrast, smaller but more frequent increases of near-bottom sediment fluxes (0.1-1.4 g m-2 s-1) were recorded during the trawling period. Despite these smaller trawling-induced sediment fluxes, 30 days of continuous bottom trawling activity transported a total amount of 0.04 T m-2, of similar magnitude to that generated by a major DSWC event (0.05 T m-2). Since bottom trawling in Palamós Canyon is practiced daily, on a weekday basis throughout the year, a much larger contribution of anthropogenically derived water turbidity and sediment transport can be expected. This study highlights the necessity of considering the contribution of bottom trawling activities in the contemporary sediment dynamics in deep-sea environments, along with the biogeochemical consequences that can be derived from it