cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.24846615.v1
title: Subject 5 scan 1

description: Subject 5 scan 1
DOI: 10.6084/m9.figshare.24846618
title: Subject 6 scan 1

description: Subject 6 scan 1
DOI: 10.6084/m9.figshare.24846618.v1
title: Subject 6 scan 1

description: Subject 6 scan 1
DOI: 10.6084/m9.figshare.24846621
title: Subject 7 scan 2

description: Subject 7 scan 2
DOI: 10.6084/m9.figshare.24846621.v1
title: Subject 7 scan 2

description: Subject 7 scan 2
DOI: 10.6084/m9.figshare.24846624
title: Subject 8 scan 3

description: Subject 8 scan 3
DOI: 10.6084/m9.figshare.24846624.v1
title: Subject 8 scan 3

description: Subject 8 scan 3
DOI: 10.6084/m9.figshare.24846627
title: Subject 10 scan 1

description: Subject 10 scan 1
DOI: 10.6084/m9.figshare.24846615
title: Subject 5 scan 1

description: Subject 5 scan 1
DOI: 10.6084/m9.figshare.24846627.v1
title: Subject 10 scan 1

description: Subject 10 scan 1
DOI: 10.6084/m9.figshare.24846630
title: Subject 13 scan 2

description: Subject 13 scan 2
DOI: 10.6084/m9.figshare.24846630.v1
title: Subject 13 scan 2

description: Subject 13 scan 2
DOI: 10.6084/m9.figshare.24846633
title: Subject 12 scan 2

description: Subject 12 scan 2
DOI: 10.6084/m9.figshare.24846636
title: Subject 14 scan 2

description: Subject 14 scan 2
DOI: 10.6084/m9.figshare.24846633.v1
title: Subject 12 scan 2

description: Subject 12 scan 2
DOI: 10.6084/m9.figshare.24846636.v1
title: Subject 14 scan 2

description: Subject 14 scan 2
DOI: 10.6084/m9.figshare.24846639
title: Subject 9 scan 1

description: Subject 9 scan 1
DOI: 10.6084/m9.figshare.24846639.v1
title: Subject 9 scan 1

description: Subject 9 scan 1
DOI: 10.6084/m9.figshare.24846642
title: Subject 15 scan 1

description: Subject 15 scan 1
DOI: 10.6084/m9.figshare.24846642.v1
title: Subject 15 scan 1

description: Subject 15 scan 1
DOI: 10.6084/m9.figshare.24846645
title: Subject 16 scan 1

description: Subject 16 scan 1
DOI: 10.6084/m9.figshare.24846645.v1
title: Subject 16 scan 1

description: Subject 16 scan 1
DOI: 10.6084/m9.figshare.24846648
title: Subject 34 scan 1

description: Subject 34 scan 1
DOI: 10.15468/dl.q7nwcc
title: Occurrence Download

description: A dataset containing 1756 species occurrences available in GBIF matching the query:
{
 "and" : [
 {
 "and" : [
 "HasGeospatialIssue is false",
 "HasCoordinate is true",
 "OccurrenceStatus is Present",
 {
 "not" : {
 "BasisOfRecord" : [
 "is one of (Fossil, Living Specimen)"
 ]
 }
 }
 ]
 },
 "SpeciesKey is Laricobius nigrinus Fender, 1945",
 "Year is greater than or equal to 2004",
 "Year is less than or equal to 2023"
 ]
}

 The dataset includes 1756 records from 4 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0080684-240626123714530/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.6084/m9.figshare.24846648.v1
title: Subject 34 scan 1

description: Subject 34 scan 1
DOI: 10.6084/m9.figshare.24846651
title: Subject 26 scan 1

description: Subject 26 scan 1
DOI: 10.6084/m9.figshare.24846651.v1
title: Subject 26 scan 1

description: Subject 26 scan 1
DOI: 10.6084/m9.figshare.24846654
title: Subject 35 scan 1

description: Subject 35 scan 1
DOI: 10.6084/m9.figshare.24846654.v1
title: Subject 35 scan 1

description: Subject 35 scan 1
DOI: 10.6084/m9.figshare.24846657
title: Subject 32 scan 1

description: Subject 32 scan 1
DOI: 10.6084/m9.figshare.24846657.v1
title: Subject 32 scan 1

description: Subject 32 scan 1
DOI: 10.6084/m9.figshare.24846660
title: Subject 17 scan 1

description: Subject 17 scan 1
DOI: 10.6084/m9.figshare.24846660.v1
title: Subject 17 scan 1

description: Subject 17 scan 1
DOI: 10.6084/m9.figshare.24846663
title: Subject 29 scan 1

description: Subject 29 scan 1
DOI: 10.6084/m9.figshare.24846663.v1
title: Subject 29 scan 1

description: Subject 29 scan 1
DOI: 10.6084/m9.figshare.24846666
title: Subject 21 scan 2

description: Subject 21 scan 2
DOI: 10.6084/m9.figshare.24846666.v1
title: Subject 21 scan 2

description: Subject 21 scan 2
DOI: 10.6084/m9.figshare.24846669
title: Subject 28 scan 1

description: Subject 28 scan 1
DOI: 10.6084/m9.figshare.24846669.v1
title: Subject 28 scan 1

description: Subject 28 scan 1
DOI: 10.6084/m9.figshare.24846672.v1
title: Subject 27 scan 1

description: Subject 27 scan 1
DOI: 10.6084/m9.figshare.24846672
title: Subject 27 scan 1

description: Subject 27 scan 1
DOI: 10.6084/m9.figshare.24846675
title: Subject 22 scan 2

description: Subject 22 scan 2
DOI: 10.6084/m9.figshare.24846675.v1
title: Subject 22 scan 2

description: Subject 22 scan 2
DOI: 10.6084/m9.figshare.24846678
title: Subject 31 scan 1

description: Subject 31 scan 1
DOI: 10.6084/m9.figshare.24846678.v1
title: Subject 31 scan 1

description: Subject 31 scan 1
DOI: 10.6084/m9.figshare.24846681
title: Subject 23 scan 1

description: Subject 23 scan 1
DOI: 10.6084/m9.figshare.24846681.v1
title: Subject 23 scan 1

description: Subject 23 scan 1
DOI: 10.6084/m9.figshare.24846684.v1
title: Subject 18 scan 3

description: Subject 18 scan 3
DOI: 10.6084/m9.figshare.24846687.v1
title: Subject 33 scan 1

description: Subject 33 scan 1
DOI: 10.6084/m9.figshare.24846684
title: Subject 18 scan 3

description: Subject 18 scan 3
DOI: 10.6084/m9.figshare.24846687
title: Subject 33 scan 1

description: Subject 33 scan 1
DOI: 10.6084/m9.figshare.24846690
title: Subject 30 scan 1

description: Subject 30 scan 1
DOI: 10.6084/m9.figshare.24846690.v1
title: Subject 30 scan 1

description: Subject 30 scan 1
DOI: 10.6084/m9.figshare.24846693
title: Subject 36 scan 2

description: Subject 36 scan 2
DOI: 10.6084/m9.figshare.24846693.v1
title: Subject 36 scan 2

description: Subject 36 scan 2
DOI: 10.6084/m9.figshare.24846696
title: Subject 38 scan 1

description: Subject 38 scan 1
DOI: 10.6084/m9.figshare.24846699
title: Subject 37 scan 2

description: Subject 37 scan 2
DOI: 10.6084/m9.figshare.24846699.v1
title: Subject 37 scan 2

description: Subject 37 scan 2
DOI: 10.6084/m9.figshare.24846702
title: Subject 36 scan 1

description: Subject 36 scan 1
DOI: 10.6084/m9.figshare.24846702.v1
title: Subject 36 scan 1

description: Subject 36 scan 1
DOI: 10.6084/m9.figshare.24846705
title: Subject 37 scan 1

description: Subject 37 scan 1
DOI: 10.6084/m9.figshare.24846705.v1
title: Subject 37 scan 1

description: Subject 37 scan 1
DOI: 10.6084/m9.figshare.24846708
title: Subject 39 scan 2

description: Subject 39 scan 2
DOI: 10.6084/m9.figshare.24846708.v1
title: Subject 39 scan 2

description: Subject 39 scan 2
DOI: 10.6084/m9.figshare.24846711
title: Subject 39 scan 1

description: Subject 39 scan 1
DOI: 10.6084/m9.figshare.24846711.v1
title: Subject 39 scan 1

description: Subject 39 scan 1
DOI: 10.6084/m9.figshare.24846714.v1
title: Subject 40 scan 2

description: Subject 40 scan 2
DOI: 10.6084/m9.figshare.24846714
title: Subject 40 scan 2

description: Subject 40 scan 2
DOI: 10.6084/m9.figshare.24846717
title: Subject 41 scan 2

description: Subject 41 scan 2
DOI: 10.6084/m9.figshare.24846717.v1
title: Subject 41 scan 2

description: Subject 41 scan 2
DOI: 10.6084/m9.figshare.24846720
title: Subject 40 scan 1

description: Subject 40 scan 1
DOI: 10.6084/m9.figshare.24846720.v1
title: Subject 40 scan 1

description: Subject 40 scan 1
DOI: 10.6084/m9.figshare.24846723
title: Subject 43 scan 2

description: Subject 43 scan 2
DOI: 10.6084/m9.figshare.24846723.v1
title: Subject 43 scan 2

description: Subject 43 scan 2
DOI: 10.6084/m9.figshare.24846726
title: Subject 45 scan 1

description: Subject 45 scan 1
DOI: 10.6084/m9.figshare.24846726.v1
title: Subject 45 scan 1

description: Subject 45 scan 1
DOI: 10.6084/m9.figshare.24846729
title: Subject 44 scan 1

description: Subject 44 scan 1
DOI: 10.6084/m9.figshare.24846729.v1
title: Subject 44 scan 1

description: Subject 44 scan 1
DOI: 10.6084/m9.figshare.24846732
title: Subject 42 scan 1

description: Subject 42 scan 1
DOI: 10.6084/m9.figshare.24846732.v1
title: Subject 42 scan 1

description: Subject 42 scan 1
DOI: 10.6084/m9.figshare.24846735
title: Subject 41 scan 1

description: Subject 41 scan 1
DOI: 10.6084/m9.figshare.24846735.v1
title: Subject 41 scan 1

description: Subject 41 scan 1
DOI: 10.6084/m9.figshare.24846738
title: Subject 41 scan 3

description: Subject 41 scan 3
DOI: 10.6084/m9.figshare.24846738.v1
title: Subject 41 scan 3

description: Subject 41 scan 3
DOI: 10.6084/m9.figshare.24846741
title: Subject 46 scan 1

description: Subject 46 scan 1
DOI: 10.6084/m9.figshare.24846741.v1
title: Subject 46 scan 1

description: Subject 46 scan 1
DOI: 10.6084/m9.figshare.24846744
title: Subject 43 scan 1

description: Subject 43 scan 1
DOI: 10.6084/m9.figshare.24846744.v1
title: Subject 43 scan 1

description: Subject 43 scan 1
DOI: 10.6084/m9.figshare.24846747
title: Subject 45 scan 2

description: Subject 45 scan 2
DOI: 10.6084/m9.figshare.24846747.v1
title: Subject 45 scan 2

description: Subject 45 scan 2
DOI: 10.6084/m9.figshare.24846750
title: Subject 48 scan 2

description: Subject 48 scan 2
DOI: 10.6084/m9.figshare.24846750.v1
title: Subject 48 scan 2

description: Subject 48 scan 2
DOI: 10.6084/m9.figshare.24846753
title: Subject 46 scan 2

description: Subject 46 scan 2
DOI: 10.6084/m9.figshare.24846753.v1
title: Subject 46 scan 2

description: Subject 46 scan 2
DOI: 10.6084/m9.figshare.24846756.v1
title: Subject 47 scan 1

description: Subject 47 scan 1
DOI: 10.6084/m9.figshare.24846759
title: Subject 48 scan 1

description: Subject 48 scan 1
DOI: 10.6084/m9.figshare.24846759.v1
title: Subject 48 scan 1

description: Subject 48 scan 1
DOI: 10.6084/m9.figshare.24846762
title: Subject 49 scan 1

description: Subject 49 scan 1
DOI: 10.6084/m9.figshare.24846762.v1
title: Subject 49 scan 1

description: Subject 49 scan 1
DOI: 10.6084/m9.figshare.24846756
title: Subject 47 scan 1

description: Subject 47 scan 1
DOI: 10.6084/m9.figshare.24846765
title: Subject 51 scan 1

description: Subject 51 scan 1
DOI: 10.6084/m9.figshare.24846765.v1
title: Subject 51 scan 1

description: Subject 51 scan 1
DOI: 10.6084/m9.figshare.24846768
title: Subject 50 scan 1

description: Subject 50 scan 1
DOI: 10.6084/m9.figshare.24846768.v1
title: Subject 50 scan 1

description: Subject 50 scan 1
DOI: 10.6084/m9.figshare.24846771
title: Subject 49 scan 2

description: Subject 49 scan 2
DOI: 10.6084/m9.figshare.24846771.v1
title: Subject 49 scan 2

description: Subject 49 scan 2
DOI: 10.6084/m9.figshare.24846774
title: Subject 52 scan 1

description: Subject 52 scan 1
DOI: 10.6084/m9.figshare.24846774.v1
title: Subject 52 scan 1

description: Subject 52 scan 1
DOI: 10.6084/m9.figshare.24846777
title: Subject 54 scan 1

description: Subject 54 scan 1
DOI: 10.6084/m9.figshare.24846777.v1
title: Subject 54 scan 1

description: Subject 54 scan 1
DOI: 10.6084/m9.figshare.24846780
title: Subject 54 scan 2

description: Subject 54 scan 2
DOI: 10.6084/m9.figshare.24846780.v1
title: Subject 54 scan 2

description: Subject 54 scan 2
DOI: 10.6084/m9.figshare.24846783
title: Subject 53 scan 2

description: Subject 53 scan 2
DOI: 10.6084/m9.figshare.24846786
title: Subject 56 scan 2

description: Subject 56 scan 2
DOI: 10.6084/m9.figshare.24846783.v1
title: Subject 53 scan 2

description: Subject 53 scan 2
DOI: 10.6084/m9.figshare.24846786.v1
title: Subject 56 scan 2

description: Subject 56 scan 2
DOI: 10.6084/m9.figshare.24846789
title: Subject 53 scan 3

description: Subject 53 scan 3
DOI: 10.6084/m9.figshare.24846789.v1
title: Subject 53 scan 3

description: Subject 53 scan 3
DOI: 10.6084/m9.figshare.24846792
title: Subject 58 scan 1

description: Subject 58 scan 1
DOI: 10.6084/m9.figshare.24846792.v1
title: Subject 58 scan 1

description: Subject 58 scan 1
DOI: 10.6084/m9.figshare.24846795
title: Subject 54 scan 3

description: Subject 54 scan 3
DOI: 10.6084/m9.figshare.24846795.v1
title: Subject 54 scan 3

description: Subject 54 scan 3
DOI: 10.6084/m9.figshare.24846798
title: Subject 53 scan 1

description: Subject 53 scan 1
DOI: 10.6084/m9.figshare.24846798.v1
title: Subject 53 scan 1

description: Subject 53 scan 1
DOI: 10.6084/m9.figshare.24846801
title: Subject 55 scan 1

description: Subject 55 scan 1
DOI: 10.6084/m9.figshare.7898792
title: Effects of exercise and metformin on the prevention of glucose intolerance: a comparative study

description: We aimed to evaluate the effects of aerobic exercise training (4 days) and metformin exposure on acute glucose intolerance after dexamethasone treatment in rats. Forty-two adult male Wistar rats (8 weeks old) were divided randomly into four groups: sedentary control (SCT), sedentary dexamethasone-treated (SDX), training dexamethasone-treated (DPE), and dexamethasone and metformin treated group (DMT). Glucose tolerance tests and in situ liver perfusion were undertaken on fasting rats to obtain glucose profiles. The DPE group displayed a significant decrease in glucose values compared with the SDX group. Average glucose levels in the DPE group did not differ from those of the DMT group, so we suggest that exercise training corrects dexamethasone-induced glucose intolerance and improves glucose profiles in a similar manner to that observed with metformin. These data suggest that exercise may prevent the development of glucose intolerance induced by dexamethasone in rats to a similar magnitude to that observed after metformin treatment.
DOI: 10.6084/m9.figshare.7898795
title: Exercise training prevents increased intraocular pressure and sympathetic vascular modulation in an experimental model of metabolic syndrome

description: The present study aimed to study the effects of exercise training (ET) performed by rats on a 10-week high-fructose diet on metabolic, hemodynamic, and autonomic changes, as well as intraocular pressure (IOP). Male Wistar rats receiving fructose overload in drinking water (100 g/L) were concomitantly trained on a treadmill for 10 weeks (FT group) or kept sedentary (F group), and a control group (C) was kept in normal laboratory conditions. The metabolic evaluation comprised the Lee index, glycemia, and insulin tolerance test (KITT). Arterial pressure (AP) was measured directly, and systolic AP variability was performed to determine peripheral autonomic modulation. ET attenuated impaired metabolic parameters, AP, IOP, and ocular perfusion pressure (OPP) induced by fructose overload (FT vs F). The increase in peripheral sympathetic modulation in F rats, demonstrated by systolic AP variance and low frequency (LF) band (F: 37±2, 6.6±0.3 vs C: 26±3, 3.6±0.5 mmHg2), was prevented by ET (FT: 29±3, 3.4±0.7 mmHg2). Positive correlations were found between the LF band and right IOP (r=0.57, P=0.01) and left IOP (r=0.64, P=0.003). Negative correlations were noted between KITT values and right IOP (r=-0.55, P=0.01) and left IOP (r=-0.62, P=0.005). ET in rats effectively prevented metabolic abnormalities and AP and IOP increases promoted by a high-fructose diet. In addition, ocular benefits triggered by exercise training were associated with peripheral autonomic improvement.
DOI: 10.6084/m9.figshare.7898807.v1
title: Alanyl-glutamine attenuates 5-fluorouracil-induced intestinal mucositis in apolipoprotein E-deficient mice

description: Apolipoprotein E (APOE=gene, apoE=protein) is a known factor regulating the inflammatory response that may have regenerative effects during tissue recovery from injury. We investigated whether apoE deficiency reduces the healing effect of alanyl-glutamine (Ala-Gln) treatment, a recognized gut-trophic nutrient, during tissue recovery after 5-FU-induced intestinal mucositis. APOE-knockout (APOE-/-) and wild-type (APOE+/+) C57BL6J male and female mice (N=86) were given either Ala-Gln (100 mM) or phosphate buffered saline (PBS) by gavage 3 days before and 5 days after a 5-fluorouracil (5-FU) challenge (450 mg/kg, via intraperitoneal injection). Mouse body weight was monitored daily. The 5-FU cytotoxic effect was evaluated by leukometry. Intestinal villus height, villus/crypt ratio, and villin expression were monitored to assess recovery of the intestinal absorptive surface area. Crypt length, mitotic, apoptotic, and necrotic crypt indexes, and quantitative real-time PCR for insulin-like growth factor-1 (IGF-1) and B-cell lymphoma 2 (Bcl-2) intestinal mRNA transcripts were used to evaluate intestinal epithelial cell turnover. 5-FU challenge caused significant weight loss and leukopenia (P&lt;0.001) in both mouse strains, which was not improved by Ala-Gln. Villus blunting, crypt hyperplasia, and reduced villus/crypt ratio (P&lt;0.05) were found in all 5-FU-challenged mice but not in PBS controls. Ala-Gln improved villus/crypt ratio, crypt length and mitotic index in all challenged mice, compared with PBS controls. Ala-Gln improved villus height only in APOE-/- mice. Crypt cell apoptosis and necrotic scores were increased in all mice challenged by 5-FU, compared with untreated controls. Those scores were significantly lower in Ala-Gln-treated APOE+/+ mice than in controls. Bcl-2 and IGF-1 mRNA transcripts were reduced only in the APOE-/--challenged mice. Altogether our findings suggest APOE-independent Ala-Gln regenerative effects after 5-FU challenge.
DOI: 10.6084/m9.figshare.7898783
title: Characterization of tolerance to citrus leafminer of Citrus and related genera

description: ABSTRACT The aim of this study was to identify resistance of tolerance type in Citrus and Poncirus genotypes towards the citrus leafminer (CLM), Phyllocnistis citrella. The quantitative variables leaf and shoot lengths, leaf width, number of larvae and new shoots, and fresh and dry shoots weights, and qualitative variables associated with foliar damage were evaluated in six Citrus-related genotypes infested with CLM. In preliminary trials with lime Rough lemon (C. jambhiri), the variables that best discriminated the infestation effect of CLM were established as the numbers of larvae and new shoots per plant together with the percentages of partially rolled leaves (PRL), rolled leaves (RL) and total damage (TD = RL + PRL). In subsequent tests with all six genotypes, the variables new shoots per plant, percentage of attacked but not rolled leaves (ANRL), RL and TD were found to be significant. Trifoliata Limeira (P. trifoliata) and hybrid C × R4 (C. sunki × P. trifoliata) presented the lowest percentages of RL and TD and the highest values of ANRL. A cluster analysis was performed considering all the variables analyzed and the most tolerant genotypes for CLM, namely hybridsC × R4, C × R315 (C. sunki × P. trifoliata), M × P222 [C. sinensis × Tangor Murcott (C. reticulata × C. sinensis)] and Trifoliata Limeira (P. trifoliata) were grouped apart from the less tolerant genotypes Sunki mandarin (C. sunki) and lime Rough lemon. In conclusion, genotypes Trifoliata Limeira and its hybrid C × R4 are the most tolerant to CLM.
DOI: 10.6084/m9.figshare.7898786
title: Activation of endogenous angiotensin converting enzyme 2 prevents early injuries induced by hyperglycemia in rat retina

description: Diabetic retinopathy (DR) is a serious complication of diabetes mellitus that may result in blindness. We evaluated the effects of activation of endogenous angiotensin converting enzyme (ACE) 2 on the early stages of DR. Rats were administered an intravenous injection of streptozotocin to induce hyperglycemia. The ACE2 activator 1-[[2-(dimethylamino) ethyl] amino]-4-(hydroxymethyl)-7-[[(4-methylphenyl) sulfonyl] oxy]-9H-xanthone 9 (XNT) was administered by daily gavage. The death of retinal ganglion cells (RGC) was evaluated in histological sections, and retinal ACE2, caspase-3, and vascular endothelial growth factor (VEGF) expressions were analyzed by immunohistochemistry. XNT treatment increased ACE2 expression in retinas of hyperglycemic (HG) rats (control: 13.81±2.71 area%; HG: 14.29±4.30 area%; HG+XNT: 26.87±1.86 area%; P&lt;0.05). Importantly, ACE2 activation significantly increased the RCG number in comparison with HG animals (control: 553.5±14.29; HG: 530.8±10.3 cells; HG+XNT: 575.3±16.5 cells; P&lt;0.05). This effect was accompanied by a reduction in the expression of caspase-3 in RGC of the HG+XNT group when compared with untreated HG rats (control: 18.74±1.59; HG: 38.39±3.39 area%; HG+XNT: 27.83±2.80 area%; P&lt;0.05). Treatment with XNT did not alter the VEGF expression in HG animals (P&gt;0.05). Altogether, these findings indicate that activation of ACE2 reduced the death of retinal ganglion cells by apoptosis in HG rats.
DOI: 10.6084/m9.figshare.7898792.v1
title: Effects of exercise and metformin on the prevention of glucose intolerance: a comparative study

description: We aimed to evaluate the effects of aerobic exercise training (4 days) and metformin exposure on acute glucose intolerance after dexamethasone treatment in rats. Forty-two adult male Wistar rats (8 weeks old) were divided randomly into four groups: sedentary control (SCT), sedentary dexamethasone-treated (SDX), training dexamethasone-treated (DPE), and dexamethasone and metformin treated group (DMT). Glucose tolerance tests and in situ liver perfusion were undertaken on fasting rats to obtain glucose profiles. The DPE group displayed a significant decrease in glucose values compared with the SDX group. Average glucose levels in the DPE group did not differ from those of the DMT group, so we suggest that exercise training corrects dexamethasone-induced glucose intolerance and improves glucose profiles in a similar manner to that observed with metformin. These data suggest that exercise may prevent the development of glucose intolerance induced by dexamethasone in rats to a similar magnitude to that observed after metformin treatment.
DOI: 10.6084/m9.figshare.7898780
title: Absorption mechanism of three curcumin constituents through in situ intestinal perfusion method

description: This study aimed to investigate the absorption mechanism of three curcumin constituents in rat small intestines. Self-emulsification was used to solubilize the three curcumin constituents, and the rat in situ intestinal perfusion method was used to study factors on drug absorption, including drug mass concentration, absorption site, and the different types and concentrations of absorption inhibitors. Within the scope of experimental concentrations, three curcumin constituents were absorbed in rat small intestines through the active transport mechanism.
DOI: 10.6084/m9.figshare.7898786.v1
title: Activation of endogenous angiotensin converting enzyme 2 prevents early injuries induced by hyperglycemia in rat retina

description: Diabetic retinopathy (DR) is a serious complication of diabetes mellitus that may result in blindness. We evaluated the effects of activation of endogenous angiotensin converting enzyme (ACE) 2 on the early stages of DR. Rats were administered an intravenous injection of streptozotocin to induce hyperglycemia. The ACE2 activator 1-[[2-(dimethylamino) ethyl] amino]-4-(hydroxymethyl)-7-[[(4-methylphenyl) sulfonyl] oxy]-9H-xanthone 9 (XNT) was administered by daily gavage. The death of retinal ganglion cells (RGC) was evaluated in histological sections, and retinal ACE2, caspase-3, and vascular endothelial growth factor (VEGF) expressions were analyzed by immunohistochemistry. XNT treatment increased ACE2 expression in retinas of hyperglycemic (HG) rats (control: 13.81±2.71 area%; HG: 14.29±4.30 area%; HG+XNT: 26.87±1.86 area%; P&lt;0.05). Importantly, ACE2 activation significantly increased the RCG number in comparison with HG animals (control: 553.5±14.29; HG: 530.8±10.3 cells; HG+XNT: 575.3±16.5 cells; P&lt;0.05). This effect was accompanied by a reduction in the expression of caspase-3 in RGC of the HG+XNT group when compared with untreated HG rats (control: 18.74±1.59; HG: 38.39±3.39 area%; HG+XNT: 27.83±2.80 area%; P&lt;0.05). Treatment with XNT did not alter the VEGF expression in HG animals (P&gt;0.05). Altogether, these findings indicate that activation of ACE2 reduced the death of retinal ganglion cells by apoptosis in HG rats.