cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.20208167.v1
title: Supplementary Material for: Predictive Value of Liver Stiffness Measurement by Magnetic Resonance Elastography for Complications after Liver Resection: A Systematic Review and Meta-Analysis

description: <b><i>Background and Aims:</i></b> Liver fibrosis has been recognized as a significant risk factor for short-term outcomes after hepatectomy. Magnetic resonance elastography (MRE) showed higher diagnostic performance in staging liver fibrosis than other elastography modalities. This study aimed to assess the accuracy of predicting postoperative complications in patients with malignant liver tumors using liver stiffness measurement (LSM) by MRE. <b><i>Methods:</i></b> After a systematic review of the relevant studies, the sensitivity, specificity, positive and negative likelihood ratios, diagnostic odds ratio, and area under the curve (AUC) for the diagnosis of postoperative complications were pooled using bivariate meta-analysis. Meanwhile, the pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to evaluate the effect. Heterogeneity was explored by sensitivity analysis, univariate meta-regression, and subgroup analysis. The potential publication bias was evaluated by the Deek’s funnel plot test. <b><i>Results:</i></b> Eight studies comprising a total of 1,154 patients that predicted postoperative outcomes as their purpose were ultimately included in the quantitative analysis. The pooled results of the meta-analysis revealed that the pooled sensitivity, specificity, and AUC were 78% (95% CI: 69–85%, Higgins’s inconsistency index [<i>I</i><sup>2</sup>] = 43.00), 75% (95% CI: 70–80%, Higgins’s inconsistency index [<i>I</i><sup>2</sup>] = 72.53), and 0.83 (95% CI: 0.80–0.86), respectively. Preoperative LSM by MRE was significantly associated with the development of overall postoperative outcomes (OR 1.78, 95% CI: 1.49–2.08). Univariate meta-regression showed that advanced fibrosis stage (≥F3), HCC patient proportion and cut-off value significantly influenced the heterogeneity of the included studies. The AUC of several novel prediction models based on LSM by MRE ranged from 0.818 to 0.911. <b><i>Conclusions:</i></b> In conclusion, liver stiffness measured by MRE was a significant predictor of postoperative outcomes in patients undergoing liver resection. Future studies could focus on setting a prognostic model integrated with LSM by MRE in distinguishing patients at high risk of posthepatectomy complications.
DOI: 10.6084/m9.figshare.19958717
title: Supplementary Material for: UPREGULATED ANGIOTENSIN IA RECEPTORS IN THE HYPOTHALAMIC PVN SENSITISE NEUROENDOCRINE VASOPRESSIN RELEASE AND BLOOD PRESSURE IN A RODENT MODEL OF POLYCYSTIC KIDNEY DISEASE.

description: Introduction: Angiotensin (Ang) II signalling in the hypothalamic paraventricular nucleus (PVN) via angiotensin type-1a receptors (AT1R) regulates vasopressin release and sympathetic nerve activity - two effectors of blood pressure regulation. We determined the cellular expression and function of AT1R in the PVN of a rodent model of polycystic kidney disease (PKD), the Lewis Polycystic Kidney (LPK) rat, to evaluate its contribution to blood pressure regulation and augmented vasopressin release in PKD. Methods: PVN AT1R gene expression was quantified with fluorescent in-situ hybridisation in LPK and control rats. PVN AT1R function was assessed with pharmacology under urethane anaesthesia in LPK and control rats instrumented to record arterial pressure and sympathetic nerve activity. Results: AT1R gene expression was upregulated in the PVN, particularly in CRH neurons, of LPK versus control rats. PVN microinjection of Ang II produced larger increases in systolic blood pressure in LPK versus control rats (36±5 vs. 17±2 mmHg; P&lt;0.01). Unexpectedly, Ang II produced regionally heterogeneous sympathoinhibition (renal: -33%; splanchnic: -12%; lumbar no change) in LPK and no change in controls. PVN pre-treatment with losartan, a competitive AT1R antagonist, blocked the Ang II-mediated renal sympathoinhibition and attenuated the pressor response observed in LPK rats. The Ang II pressor effect was also blocked by systemic OPC-21268, a competitive V1A receptor antagonist, but unaffected by hexamethonium, a sympathetic ganglionic blocker. Discussion/Conclusion: Collectively, our data suggest that upregulated AT1R expression in PVN sensitises neuroendocrine release of vasopressin in the LPK, identifying a central mechanism for the elevated vasopressin levels present in PKD.
DOI: 10.6084/m9.figshare.19958717.v1
title: Supplementary Material for: UPREGULATED ANGIOTENSIN IA RECEPTORS IN THE HYPOTHALAMIC PVN SENSITISE NEUROENDOCRINE VASOPRESSIN RELEASE AND BLOOD PRESSURE IN A RODENT MODEL OF POLYCYSTIC KIDNEY DISEASE.

description: Introduction: Angiotensin (Ang) II signalling in the hypothalamic paraventricular nucleus (PVN) via angiotensin type-1a receptors (AT1R) regulates vasopressin release and sympathetic nerve activity - two effectors of blood pressure regulation. We determined the cellular expression and function of AT1R in the PVN of a rodent model of polycystic kidney disease (PKD), the Lewis Polycystic Kidney (LPK) rat, to evaluate its contribution to blood pressure regulation and augmented vasopressin release in PKD. Methods: PVN AT1R gene expression was quantified with fluorescent in-situ hybridisation in LPK and control rats. PVN AT1R function was assessed with pharmacology under urethane anaesthesia in LPK and control rats instrumented to record arterial pressure and sympathetic nerve activity. Results: AT1R gene expression was upregulated in the PVN, particularly in CRH neurons, of LPK versus control rats. PVN microinjection of Ang II produced larger increases in systolic blood pressure in LPK versus control rats (36±5 vs. 17±2 mmHg; P&lt;0.01). Unexpectedly, Ang II produced regionally heterogeneous sympathoinhibition (renal: -33%; splanchnic: -12%; lumbar no change) in LPK and no change in controls. PVN pre-treatment with losartan, a competitive AT1R antagonist, blocked the Ang II-mediated renal sympathoinhibition and attenuated the pressor response observed in LPK rats. The Ang II pressor effect was also blocked by systemic OPC-21268, a competitive V1A receptor antagonist, but unaffected by hexamethonium, a sympathetic ganglionic blocker. Discussion/Conclusion: Collectively, our data suggest that upregulated AT1R expression in PVN sensitises neuroendocrine release of vasopressin in the LPK, identifying a central mechanism for the elevated vasopressin levels present in PKD.
DOI: 10.6084/m9.figshare.20072687.v1
title: Supplementary Material for: Conventional or drug-eluting beads? Randomized study of chemo-embolization for hepatocellular carcinoma: JIVROSG-1302

description: Introduction With the advent of effective systemic therapy, transarterial chemoembolization (TACE) is established as a highly effective locoregional treatment modality for carefully selected patients of hepatocellular carcinoma (HCC). This randomized controlled trial was conducted to clarify whether selective TACE with drug-eluting beads loaded with epirubicin (DEB-TACE) or selective conventional TACE with epirubicin-ethiodized oil (cTACE) might be more effective for obtaining complete response (CR) in patients with HCC. Methods Between March 2016 and May 2019, Child-Pugh class A or B patients with unresectable HCC who were scheduled to receive selective TACE were randomly assigned at a 1:1 ratio to the DEB-TACE arm or the cTACE arm. The primary endpoint was the CR rate at 3 months, as evaluated according to the modified Response Evaluation Criteria in Solid Tumors (mRECIST) by an independent review committee, and the secondary endpoints were the CR rate at 1 month and incidences of adverse events. Results A total of 200 patients (DEB-TACE, 99 patients; cTACE, 101 patients) were enrolled in the study. The CR rates at 3 months and 1 month were significantly higher in the cTACE arm (75.2%, 84.2%) as compared with the DEB-TACE arm (27.6%, 35.7%). However, the frequencies of adverse events of any grade, including pyrexia (DEB-TACE vs. cTACE, 19.4% vs. 45.5%, p=0.0001), fatigue (5.1% vs. 15.8%, p=0.0194), malaise (11.1% vs. 25.7%, p=0.0103), appetite loss (12.1% vs. 28.7%, p=0.0048), abdominal pain (12.1% vs. 23.8%, p=0.0423), increased serum bilirubin (22.2% vs. 48.5%, p=0.0002), hypoalbuminemia (43.4% vs. 60.3%, p=0.0154), increased serum aspartate aminotransferase (35.7% vs. 81.2%, p&lt;0.0001), and increased serum alanine aminotransferase (35.7% vs. 77.2%, p&lt;0.0001), were also significantly higher in the cTACE arm than in the DEB-TACE arm. Conclusions Selective cTACE appeared to have higher CR rates for local tumor control as compared to selective DEB-TACE for HCC. However, the frequency of post-embolization syndrome was also significantly higher in the cTACE group than in the DEB-TACE group. Thus, to achieve CR, cTACE may be selected over DEB-TACE in patients who can be expected to tolerate post-embolization syndrome.
DOI: 10.6084/m9.figshare.20208755
title: Supplementary Material for: ANXA10 Expression Is Inversely Associated with Tumor Stage, Grade, and TP53 Expression in Upper and Lower Urothelial Carcinoma

description: <b><i>Introduction:</i></b> Urothelial carcinoma (UC) is a common type of malignant disease, but little is known about the diagnostic and prognostic markers of upper urinary tract urothelial cancer (UTUC) because of its rarity. To clarify the significance of ANXA10 in UTUC, we studied ANXA10 expression with immunohistochemistry (IHC). <b><i>Methods:</i></b> The expression of ANXA10 was analyzed in the upper and lower urinary tract of UC by IHC in combination with The Cancer Genome Atlas (TCGA) data analysis. The association between ANXA10 expression and representative cancer-related molecules was also evaluated. <b><i>Results:</i></b> ANXA10 expression was weak in normal upper tract urothelium but was positive in 39/117 (33%) UTUCs. ANXA10 was more frequently positive in tumors with pure UC (36%, <i>p</i> &lt; 0.05), papillary morphology (50%, <i>p</i> &lt; 0.01), low grade (G1/2: 57%, <i>p</i> &lt; 0.01), and pTa/is/1 stage (55%, <i>p</i> &lt; 0.01) than in those with histological variants (0%), nodular morphology (9%), G3 (16%), and pT2/3/4 (13%), respectively. ANXA10-positive patients showed better cancer-specific survival and progression-free survival than ANXA10-negative patients (<i>p</i> &lt; 0.05). IHC showed that ANXA10 positivity was detected more in cases with the low expression of TP53 (<i>p</i> &lt; 0.01) and Ki-67 labeling index &lt;20% (<i>p</i> &lt; 0.01). In TCGA dataset of muscle-invasive bladder cancer, higher ANXA10 expression correlated with papillary morphology, lower grade/stage, luminal papillary subtype, wild-type TP53, and FGFR3 gene mutation. <b><i>Conclusion:</i></b> We revealed that ANXA10 expression was increased during carcinogenesis and was observed more frequently in papillary UC of lower grade and stage. However, its expression decreased as cancer progressed. Therefore, the ANXA10 expression in UTUC might be clinically useful for decision-making.
DOI: 10.34740/kaggle/dsv/3888168
title: YouTube Daily
DOI: 10.6084/m9.figshare.19969907
title: Transforming Chemical Proteomics Enrichment into a High-Throughput Method Using an SP2E Workflow.

description: Supporting Tables containing list of measured samples, LFQ intensitites, fold enrichment and significance.
DOI: 10.6084/m9.figshare.19969907.v1
title: Transforming Chemical Proteomics Enrichment into a High-Throughput Method Using an SP2E Workflow.

description: Supporting Tables containing list of measured samples, LFQ intensitites, fold enrichment and significance.
DOI: 10.6084/m9.figshare.15015927.v1
title: CaliPopGen Dataset 2: Pairwise Population Differentiation

description: The Pairwise Population Differentiation dataset consists of 106 columns, described in Table 2 of the original publication, comprised of data from 199 studies on 193 species and 14,703 pairwise population comparisons, with the latter equaling the number of rows. The first 36 columns summarize taxonomic, population, marker type, and pairwise population comparison data, while the remaining 70 columns contain data on animal and plant life history (Dataset 3 and Dataset 4, respectively). XLSX format.
DOI: 10.6084/m9.figshare.15015918
title: CaliPopGen Dataset 3: Animal Life History Traits

description: The Animal Life History Traits dataset consists of 45 columns, containing data for 432 species and subspecies, and is described in Table 3 of the original publication. The first 29 columns describe the life history of species and subspecies, and give details on their conservation status, while columns 30-45 provide information on the sources of these data. TSV format.
DOI: 10.6084/m9.figshare.15015921
title: CaliPopGen Dataset 1: Population Genetic Diversity

description: The Population Genetic Diversity dataset consists of 101 columns, described in Table 1 of the original publication, comprised of data from 446 studies on 437 species and 4,622 unique species-population-marker type combinations, with the latter equaling the number of rows in the dataset. The first 31 columns summarize taxonomic, population, marker type, and genetic data, while the remaining 70 columns contain data on animal and plant life history (Dataset 3 and Dataset 4, respectively). XLSX format.
DOI: 10.6084/m9.figshare.15015921.v1
title: CaliPopGen Dataset 1: Population Genetic Diversity

description: The Population Genetic Diversity dataset consists of 101 columns, described in Table 1 of the original publication, comprised of data from 446 studies on 437 species and 4,622 unique species-population-marker type combinations, with the latter equaling the number of rows in the dataset. The first 31 columns summarize taxonomic, population, marker type, and genetic data, while the remaining 70 columns contain data on animal and plant life history (Dataset 3 and Dataset 4, respectively). XLSX format.
DOI: 10.6084/m9.figshare.15015924
title: CaliPopGen Dataset 1: Population Genetic Diversity

description: The Population Genetic Diversity dataset consists of 101 columns, described in Table 1 of the original publication, comprised of data from 446 studies on 437 species and 4,622 unique species-population-marker type combinations, with the latter equaling the number of rows in the dataset. The first 31 columns summarize taxonomic, population, marker type, and genetic data, while the remaining 70 columns contain data on animal and plant life history (Dataset 3 and Dataset 4, respectively). CSV format.
DOI: 10.6084/m9.figshare.15015930
title: CaliPopGen Dataset 2: Pairwise Population Differentiation

description: The Pairwise Population Differentiation dataset consists of 106 columns, described in Table 2 of the original publication, comprised of data from 199 studies on 193 species and 14,703 pairwise population comparisons, with the latter equaling the number of rows. The first 36 columns summarize taxonomic, population, marker type, and pairwise population comparison data, while the remaining 70 columns contain data on animal and plant life history (Dataset 3 and Dataset 4, respectively). CSV format.
DOI: 10.6084/m9.figshare.15015930.v1
title: CaliPopGen Dataset 2: Pairwise Population Differentiation

description: The Pairwise Population Differentiation dataset consists of 106 columns, described in Table 2 of the original publication, comprised of data from 199 studies on 193 species and 14,703 pairwise population comparisons, with the latter equaling the number of rows. The first 36 columns summarize taxonomic, population, marker type, and pairwise population comparison data, while the remaining 70 columns contain data on animal and plant life history (Dataset 3 and Dataset 4, respectively). CSV format.
DOI: 10.6084/m9.figshare.15015927
title: CaliPopGen Dataset 2: Pairwise Population Differentiation

description: The Pairwise Population Differentiation dataset consists of 106 columns, described in Table 2 of the original publication, comprised of data from 199 studies on 193 species and 14,703 pairwise population comparisons, with the latter equaling the number of rows. The first 36 columns summarize taxonomic, population, marker type, and pairwise population comparison data, while the remaining 70 columns contain data on animal and plant life history (Dataset 3 and Dataset 4, respectively). XLSX format.
DOI: 10.6084/m9.figshare.15015933
title: CaliPopGen Dataset 1: Population Genetic Diversity

description: The Population Genetic Diversity dataset consists of 101 columns, described in Table 1 of the original publication, comprised of data from 446 studies on 437 species and 4,622 unique species-population-marker type combinations, with the latter equaling the number of rows in the dataset. The first 31 columns summarize taxonomic, population, marker type, and genetic data, while the remaining 70 columns contain data on animal and plant life history (Dataset 3 and Dataset 4, respectively). TSV format.
DOI: 10.6084/m9.figshare.15015933.v1
title: CaliPopGen Dataset 1: Population Genetic Diversity

description: The Population Genetic Diversity dataset consists of 101 columns, described in Table 1 of the original publication, comprised of data from 446 studies on 437 species and 4,622 unique species-population-marker type combinations, with the latter equaling the number of rows in the dataset. The first 31 columns summarize taxonomic, population, marker type, and genetic data, while the remaining 70 columns contain data on animal and plant life history (Dataset 3 and Dataset 4, respectively). TSV format.
DOI: 10.6084/m9.figshare.15015936.v1
title: CaliPopGen Dataset 2: Pairwise Population Differentiation

description: The Pairwise Population Differentiation dataset consists of 106 columns, described in Table 2 of the original publication, comprised of data from 199 studies on 193 species and 14,703 pairwise population comparisons, with the latter equaling the number of rows. The first 36 columns summarize taxonomic, population, marker type, and pairwise population comparison data, while the remaining 70 columns contain data on animal and plant life history (Dataset 3 and Dataset 4, respectively). TSV format.
DOI: 10.6084/m9.figshare.15015939.v1
title: CaliPopGen Dataset 4: Plant Life History Traits

description: The Plant Life History Traits dataset consists of 37 columns containing data for 177 species and is described in Table 4 of the original publication. The first 23 columns describe the life-history of species and subspecies, and give details on their conservation status, while columns 24-37 provide sources of data. TSV format.
DOI: 10.6084/m9.figshare.15015942.v1
title: CaliPopGen Dataset 3: Animal Life History Traits

description: The Animal Life History Traits dataset consists of 45 columns, containing data for 432 species and subspecies, and is described in Table 3 of the original publication. The first 29 columns describe the life history of species and subspecies, and give details on their conservation status, while columns 30-45 provide information on the sources of these data. CSV format.
DOI: 10.6084/m9.figshare.15015936
title: CaliPopGen Dataset 2: Pairwise Population Differentiation

description: The Pairwise Population Differentiation dataset consists of 106 columns, described in Table 2 of the original publication, comprised of data from 199 studies on 193 species and 14,703 pairwise population comparisons, with the latter equaling the number of rows. The first 36 columns summarize taxonomic, population, marker type, and pairwise population comparison data, while the remaining 70 columns contain data on animal and plant life history (Dataset 3 and Dataset 4, respectively). TSV format.
DOI: 10.6084/m9.figshare.15015942
title: CaliPopGen Dataset 3: Animal Life History Traits

description: The Animal Life History Traits dataset consists of 45 columns, containing data for 432 species and subspecies, and is described in Table 3 of the original publication. The first 29 columns describe the life history of species and subspecies, and give details on their conservation status, while columns 30-45 provide information on the sources of these data. CSV format.
DOI: 10.6084/m9.figshare.15015939
title: CaliPopGen Dataset 4: Plant Life History Traits

description: The Plant Life History Traits dataset consists of 37 columns containing data for 177 species and is described in Table 4 of the original publication. The first 23 columns describe the life-history of species and subspecies, and give details on their conservation status, while columns 24-37 provide sources of data. TSV format.
DOI: 10.6084/m9.figshare.15015945
title: CaliPopGen Dataset 4: Plant Life History Traits

description: The Plant Life History Traits dataset consists of 37 columns containing data for 177 species and is described in Table 4 of the original publication. The first 23 columns describe the life-history of species and subspecies, and give details on their conservation status, while columns 24-37 provide sources of data. XLSX format.
DOI: 10.6084/m9.figshare.15015945.v1
title: CaliPopGen Dataset 4: Plant Life History Traits

description: The Plant Life History Traits dataset consists of 37 columns containing data for 177 species and is described in Table 4 of the original publication. The first 23 columns describe the life-history of species and subspecies, and give details on their conservation status, while columns 24-37 provide sources of data. XLSX format.
DOI: 10.6084/m9.figshare.15015948
title: CaliPopGen Dataset 4: Plant Life History Traits

description: The Plant Life History Traits dataset consists of 37 columns containing data for 177 species and is described in Table 4 of the original publication. The first 23 columns describe the life-history of species and subspecies, and give details on their conservation status, while columns 24-37 provide sources of data. CSV format.
DOI: 10.6084/m9.figshare.15015948.v1
title: CaliPopGen Dataset 4: Plant Life History Traits

description: The Plant Life History Traits dataset consists of 37 columns containing data for 177 species and is described in Table 4 of the original publication. The first 23 columns describe the life-history of species and subspecies, and give details on their conservation status, while columns 24-37 provide sources of data. CSV format.
DOI: 10.6084/m9.figshare.15015951.v1
title: CaliPopGen Dataset 3: Animal Life History Traits

description: The Animal Life History Traits dataset consists of 45 columns, containing data for 432 species and subspecies, and is described in Table 3 of the original publication. The first 29 columns describe the life history of species and subspecies, and give details on their conservation status, while columns 30-45 provide information on the sources of these data. XLSX format.
DOI: 10.6084/m9.figshare.15015951
title: CaliPopGen Dataset 3: Animal Life History Traits

description: The Animal Life History Traits dataset consists of 45 columns, containing data for 432 species and subspecies, and is described in Table 3 of the original publication. The first 29 columns describe the life history of species and subspecies, and give details on their conservation status, while columns 30-45 provide information on the sources of these data. XLSX format.