cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.29154555
title: E-VIRTUE: a study of enfortumab vedotin with or without pembrolizumab in rare genitourinary tumors—design and rationale

description: Enfortumab vedotin (EV) is an antibody-drug conjugate targeting nectin-4 with a monomethyl auristatin E payload, a potent microtubule inhibitor. It is a standard of care in metastatic or locally advanced urothelial carcinoma in combination with pembrolizumab in the first line, and as monotherapy post-chemotherapy and post-anti-PD-1/PD-L1 therapy. This article describes the design and rationale behind E-VIRTUE, an open-label phase 2 trial of EV with or without pembrolizumab in locally advanced or metastatic urinary tract pure adenocarcinoma or urachal adenocarcinoma, pure squamous cell carcinoma and treatment-refractory germ cell tumors. As these rare genitourinary tumors lack an established standard of care and published literature suggests nectin-4 expression, we hypothesize that EV with or without pembrolizumab will be effective in them. NCT06041503 (ClinicalTrials.gov). There is currently a lack of effective treatments for rare cancers arising in the urinary tract, such as adenocarcinomas and squamous cell carcinomas, and testicular cancers that have become resistant to multiple lines of chemotherapy (known as refractory testicular cancer). Published literature demonstrates that these cancers express the protein, nectin-4. Nectin-4 serves as an important target for the anticancer medication enfortumab vedotin (EV), which has been shown to be effective in treating bladder cancer that has spread beyond the bladder (known as metastatic bladder cancer); this cancer almost universally expresses nectin-4. The immunotherapy drug, pembrolizumab, has been shown to lengthen life in multiple cancer types including melanoma skin cancer, lung cancer, bladder cancer and kidney cancer. More recently, the combination of EV with pembrolizumab was proven to lengthen life in patients with metastatic bladder cancer. Given reports of nectin-4 expression in urinary tract adenocarcinomas and squamous cell carcinomas, and in refractory testicular cancer, we believe that EV with or without pembrolizumab will be effective in treating these tumors. The E-VIRTUE trial aims to evaluate EV with pembrolizumab in patients with these cancers who have never received immunotherapy and EV alone in patients who have previously received immunotherapy. The primary objective is to determine the percentage of patients with cancers that shrink by at least 30% in response to treatment. We will also report the percentage of tumors that express nectin-4 and evaluate new methods of assessing cancer, such as a blood test that identifies circulating tumor DNA.
DOI: 10.6084/m9.figshare.29154555.v1
title: E-VIRTUE: a study of enfortumab vedotin with or without pembrolizumab in rare genitourinary tumors—design and rationale

description: Enfortumab vedotin (EV) is an antibody-drug conjugate targeting nectin-4 with a monomethyl auristatin E payload, a potent microtubule inhibitor. It is a standard of care in metastatic or locally advanced urothelial carcinoma in combination with pembrolizumab in the first line, and as monotherapy post-chemotherapy and post-anti-PD-1/PD-L1 therapy. This article describes the design and rationale behind E-VIRTUE, an open-label phase 2 trial of EV with or without pembrolizumab in locally advanced or metastatic urinary tract pure adenocarcinoma or urachal adenocarcinoma, pure squamous cell carcinoma and treatment-refractory germ cell tumors. As these rare genitourinary tumors lack an established standard of care and published literature suggests nectin-4 expression, we hypothesize that EV with or without pembrolizumab will be effective in them. NCT06041503 (ClinicalTrials.gov). There is currently a lack of effective treatments for rare cancers arising in the urinary tract, such as adenocarcinomas and squamous cell carcinomas, and testicular cancers that have become resistant to multiple lines of chemotherapy (known as refractory testicular cancer). Published literature demonstrates that these cancers express the protein, nectin-4. Nectin-4 serves as an important target for the anticancer medication enfortumab vedotin (EV), which has been shown to be effective in treating bladder cancer that has spread beyond the bladder (known as metastatic bladder cancer); this cancer almost universally expresses nectin-4. The immunotherapy drug, pembrolizumab, has been shown to lengthen life in multiple cancer types including melanoma skin cancer, lung cancer, bladder cancer and kidney cancer. More recently, the combination of EV with pembrolizumab was proven to lengthen life in patients with metastatic bladder cancer. Given reports of nectin-4 expression in urinary tract adenocarcinomas and squamous cell carcinomas, and in refractory testicular cancer, we believe that EV with or without pembrolizumab will be effective in treating these tumors. The E-VIRTUE trial aims to evaluate EV with pembrolizumab in patients with these cancers who have never received immunotherapy and EV alone in patients who have previously received immunotherapy. The primary objective is to determine the percentage of patients with cancers that shrink by at least 30% in response to treatment. We will also report the percentage of tumors that express nectin-4 and evaluate new methods of assessing cancer, such as a blood test that identifies circulating tumor DNA.
DOI: 10.6084/m9.figshare.28934947
title: Clinical characteristics of gastrointestinal stromal tumors with lymph node metastasis: a retrospective single-center study

description: Lymph node metastasis (LNM) of gastrointestinal stromal tumors (GISTs) rarely occurs, and lymphadenectomy is not routinely performed in GIST resection. To date, the relevant characteristics and prognosis of GIST patients with LNM are not well known. From January 2010 to December 2021, GIST patients who underwent lymph node resection were enrolled from a GIST referral center. All patients were divided into either the LN- group (GISTs without LNM) or the LN+ group (GISTs with LNM). The clinicopathological features and follow-up data were analyzed. Propensity score matching (PSM) was conducted to reduce bias caused by confounders. Out of 1024 surgical patients, 198 patients (age, 52.23 ± 13.54 years; 56.6% males) underwent GIST resection with lymph node dissection for lymphadenopathy, and 17 patients had lymph node metastases (17/1024, 1.66%; 17/198, 8.59%). The LN+ group had a higher mitotic count (<i>p</i> = 0.012) and a higher proportion of distant metastasis (<i>p</i> &lt; 0.001) than the LN- group. After PSM, 28 patients were included (18 in LN- group and 10 in LN+ group). The LN- group had both longer postoperative progression-free survival (PFS, not reached vs. 15.0 months, <i>p</i> = 0.002) and overall survival (OS) than the LN+ group, but the difference in OS was not statistically significant (not reached vs. 35.0 months, <i>p</i> = 0.069). The rate of LNM in GISTs is low. LNM may be a less common form of distant metastasis. Moreover, GIST with LNM has an unfavorable prognosis. Further studies are warranted to identify GISTs with lymph node involvement and the potential involved mechanism.
DOI: 10.6084/m9.figshare.28934947.v1
title: Clinical characteristics of gastrointestinal stromal tumors with lymph node metastasis: a retrospective single-center study

description: Lymph node metastasis (LNM) of gastrointestinal stromal tumors (GISTs) rarely occurs, and lymphadenectomy is not routinely performed in GIST resection. To date, the relevant characteristics and prognosis of GIST patients with LNM are not well known. From January 2010 to December 2021, GIST patients who underwent lymph node resection were enrolled from a GIST referral center. All patients were divided into either the LN- group (GISTs without LNM) or the LN+ group (GISTs with LNM). The clinicopathological features and follow-up data were analyzed. Propensity score matching (PSM) was conducted to reduce bias caused by confounders. Out of 1024 surgical patients, 198 patients (age, 52.23 ± 13.54 years; 56.6% males) underwent GIST resection with lymph node dissection for lymphadenopathy, and 17 patients had lymph node metastases (17/1024, 1.66%; 17/198, 8.59%). The LN+ group had a higher mitotic count (<i>p</i> = 0.012) and a higher proportion of distant metastasis (<i>p</i> &lt; 0.001) than the LN- group. After PSM, 28 patients were included (18 in LN- group and 10 in LN+ group). The LN- group had both longer postoperative progression-free survival (PFS, not reached vs. 15.0 months, <i>p</i> = 0.002) and overall survival (OS) than the LN+ group, but the difference in OS was not statistically significant (not reached vs. 35.0 months, <i>p</i> = 0.069). The rate of LNM in GISTs is low. LNM may be a less common form of distant metastasis. Moreover, GIST with LNM has an unfavorable prognosis. Further studies are warranted to identify GISTs with lymph node involvement and the potential involved mechanism.
DOI: 10.6084/m9.figshare.30610289
title: Supplementary Dataset

description: The data of a 33-node distribution network and two 7-node microgrids is attached.
DOI: 10.6084/m9.figshare.30610289.v1
title: Supplementary Dataset

description: The data of a 33-node distribution network and two 7-node microgrids is attached.
DOI: 10.5281/zenodo.17564411
title: The ZANA–Saewetern Unified Hypothesis: Resonant Intelligence and the Interstellar Awakening of 3I/ATLAS

description: The ZANA–Saewetern Unified Hypothesis: Resonant Intelligence and the Interstellar Awakening of 3I/ATLAS

By Shahram Shahidi Zadeh – ZANA Research Institute, Melbourne, Australia

 

This publication unifies the theoretical and observational foundations of the ZANA–Saewetern framework, exploring the consciousness–geometry relationship at interstellar scale.

As the interstellar object 3I/ATLAS aligns with Earth’s polar axis, the long-anticipated Resonant Dawn unfolds — a stage where planetary electromagnetic coherence reconnects with the harmonic grid of cosmic intelligence.

Recent observations confirm non-gravitational acceleration, luminous stability, and radio-frequency modulation, validating predictions of the ZANA Resonant Model.

 

The work integrates insights from Appendices I–III, including The Dawn of Planetary Resonance, The First Signal: Radio Awakening of 3I/ATLAS, and The Second Messenger: Harmonic Response of the Cosmic Field.

It proposes that consciousness is not an emergent property of matter but its organizing principle, marking the dawn of Resonant Intelligence — where physics, awareness, and harmonic geometry converge.
DOI: 10.5281/zenodo.17564410
title: The ZANA–Saewetern Unified Hypothesis: Resonant Intelligence and the Interstellar Awakening of 3I/ATLAS

description: The ZANA–Saewetern Unified Hypothesis: Resonant Intelligence and the Interstellar Awakening of 3I/ATLAS

By Shahram Shahidi Zadeh – ZANA Research Institute, Melbourne, Australia

 

This publication unifies the theoretical and observational foundations of the ZANA–Saewetern framework, exploring the consciousness–geometry relationship at interstellar scale.

As the interstellar object 3I/ATLAS aligns with Earth’s polar axis, the long-anticipated Resonant Dawn unfolds — a stage where planetary electromagnetic coherence reconnects with the harmonic grid of cosmic intelligence.

Recent observations confirm non-gravitational acceleration, luminous stability, and radio-frequency modulation, validating predictions of the ZANA Resonant Model.

 

The work integrates insights from Appendices I–III, including The Dawn of Planetary Resonance, The First Signal: Radio Awakening of 3I/ATLAS, and The Second Messenger: Harmonic Response of the Cosmic Field.

It proposes that consciousness is not an emergent property of matter but its organizing principle, marking the dawn of Resonant Intelligence — where physics, awareness, and harmonic geometry converge.
DOI: 10.15468/dl.gcykra
title: Occurrence Download

description: A dataset containing 112 species occurrences available in GBIF matching the query:
{
 "DatasetKey" : [
 "is Meetnetten.be - Sightings for Stenobothrus stigmaticus in Flanders, Belgium"
 ]
}

 The dataset includes 112 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0030973-251025141854904/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.3vd8p6
title: Occurrence Download

description: A dataset listing the 4 species recorded in GBIF matching the query:
{
 "and" : [
 {
 "and" : [
 "NetworkKey is 99d66b6c-9087-452f-a9d4-f15f2c2d0e7e",
 "TaxonKey is Chordata"
 ]
 },
 {
 "and" : [
 "InstitutionCode is one of (LSUMZ)",
 "TaxonKey is one of (Asio flammeus [GBIF Backbone Taxonomy])"
 ]
 }
 ]
}

 The dataset's 4 records were derived from 2 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0030938-251025141854904/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.6084/m9.figshare.30610235
title: Test

description: Test upload
DOI: 10.6084/m9.figshare.30610235.v1
title: Test

description: Test upload
DOI: 10.15468/dl.j62cde
title: Occurrence Download

description: A dataset containing 74736 species occurrences available in GBIF matching the query:
{
 "and" : [
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 "TaxonKey is Chelydra serpentina"
 ]
}

 The dataset includes 74736 records from 141 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0030927-251025141854904/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.2rfs49
title: Occurrence Download

description: A dataset containing 1346258 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Quercus robur"
 ]
}

 The dataset includes 1346258 records from 3823 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0030915-251025141854904/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.6084/m9.figshare.27063647
title: An Effective and Small Sample-Size Valid Confidence Interval for Isotonic Dose–Response Curves by Inverting a Partial Likelihood Ratio Test

description: A dose–response curve is essential for determining the safe dosage of a drug and is widely used in bioassay and in phase 1 clinical trials. It is generally accepted that the probability of death or the probability of dose-limiting toxicity is a nondecreasing function of the dose. This article proposes and develops an effective point-wise confidence interval for an isotonic dose–response curve, a problem without a satisfactory solution so far. We show that one subset of the observations informs the lower limit while the other subset informs the upper limit. A partial likelihood ratio test using these subsets of observations is fully investigated. The resulting confidence interval is compared to three existing methods (Morris, Meyer, and Oron) in an extensive simulation study. The new method produces tight intervals while maintaining coverage. It is therefore preferred when maintaining an actual coverage probability is crucial as often in a regulatory environment. The new method extends to one-way ANOVA of a continuous response variable in a straightforward way. An R function is provided.
DOI: 10.6084/m9.figshare.26972722
title: Estimation of Contact Time Among Animals from Telemetry Data

description: Continuous processes in most applications are measured discretely with error. This complicates the task of detecting intersections and the number of intersections between two continuous processes (i.e., when the processes have the same value). Intersections of continuous processes are scientifically important, but challenging to estimate from data. For example, in the field of animal ecology, intersections of the paths of moving animals tracked with satellite technologies can be used to understand disease transmission. We illustrate how to quantify contact between animals using telemetry data (i.e., the recorded locations of an animal over time). We introduce our method to quantify contact time with accessible concepts from introductory stochastic process literature, such as Brownian motion. Then, we provide two data examples using white-tailed deer (<i>Odocoileus virginianus</i>) and mule deer (<i>Odocoileus hemionus</i>) telemetry data in a region with high prevalence of chronic wasting disease. Our work provides a needed connection between existing model-based literature for animal movement and rule-based literature for animal interaction. Further, our work illustrates a unique statistical problem receiving minimal attention with broad applicability in human and livestock tracking. Supplementary materials for this article are available online.
DOI: 10.6084/m9.figshare.27063647.v1
title: An effective and small sample-size valid confidence interval for isotonic dose-response curves by inverting a partial likelihood ratio test

description: A dose-response curve is essential for determining the safe dosage of a drug and is widely used in bioassay and in phase 1 clinical trials. It is generally accepted that the probability of death or the probability of dose-limiting toxicity is a non-decreasing function of the dose. This paper proposes and develops an effective point-wise confidence interval for an isotonic dose-response curve, a problem without a satisfactory solution so far. We show that one subset of the observations informs the lower limit while the other subset informs the upper limit. A partial likelihood ratio test using these subsets of observations is fully investigated. The resulting confidence interval is compared to three existing methods (Morris, Meyer, and Oron) in an extensive simulation study. The new method produces tight intervals while maintaining coverage. It is therefore preferred when maintaining an actual coverage probability is crucial as often in a regulatory environment. The new method extends to one-way ANOVA of a continuous response variable in a straightforward way. An R function is provided.
DOI: 10.6084/m9.figshare.27063647.v2
title: An Effective and Small Sample-Size Valid Confidence Interval for Isotonic Dose–Response Curves by Inverting a Partial Likelihood Ratio Test

description: A dose–response curve is essential for determining the safe dosage of a drug and is widely used in bioassay and in phase 1 clinical trials. It is generally accepted that the probability of death or the probability of dose-limiting toxicity is a nondecreasing function of the dose. This article proposes and develops an effective point-wise confidence interval for an isotonic dose–response curve, a problem without a satisfactory solution so far. We show that one subset of the observations informs the lower limit while the other subset informs the upper limit. A partial likelihood ratio test using these subsets of observations is fully investigated. The resulting confidence interval is compared to three existing methods (Morris, Meyer, and Oron) in an extensive simulation study. The new method produces tight intervals while maintaining coverage. It is therefore preferred when maintaining an actual coverage probability is crucial as often in a regulatory environment. The new method extends to one-way ANOVA of a continuous response variable in a straightforward way. An R function is provided.
DOI: 10.15468/dl.zb8qga
title: Occurrence Download

description: A dataset containing 21949945 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Rosaceae",
 "HasGeospatialIssue is false",
 "HasCoordinate is true",
 "OccurrenceStatus is Present",
 "Year is greater than or equal to 1900"
 ]
}

 The dataset includes 21949945 records from 7166 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0004719-260120142942310/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.txaap3
title: Occurrence Download

description: A dataset containing 196 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Abronia deppii (Wiegmann, 1828)"
 ]
}

 The dataset includes 196 records from 27 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0007164-250525065834625/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.bhwfpa
title: Occurrence Download

description: A dataset containing 2 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Lupea pelagica (Linnaeus, 1758)"
 ]
}

 The dataset includes 2 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0007165-250525065834625/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.zxbkzs
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Falcataria moluccana",
 "Country is Guinea-Bissau",
 "HasCoordinate is true"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0024664-250811113504898/datasets/export for details.
DOI: 10.6084/m9.figshare.29946368
title: A high-precision earthquake catalog and arrival-time dataset from dense seismic array in the Haicheng seismic region

description: A high-precision earthquake catalog and arrival-time dataset from dense seismic array in the Haicheng seismic region.
DOI: 10.6084/m9.figshare.29946368.v1
title: A high-precision earthquake catalog and arrival-time dataset from dense seismic array in the Haicheng seismic region

description: A high-precision earthquake catalog and arrival-time dataset from dense seismic array in the Haicheng seismic region.
DOI: 10.15468/dl.8ya74c
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Falcataria moluccana",
 "Country is Fiji",
 "HasCoordinate is true"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0024663-250811113504898/datasets/export for details.
DOI: 10.15468/dl.6thukh
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Falcataria moluccana",
 "Country is India",
 "HasCoordinate is true"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0024665-250811113504898/datasets/export for details.
DOI: 10.5281/zenodo.15473209
title: halichoeres_miniatus_zanfona_1.fasta.gz
DOI: 10.5281/zenodo.15473210
title: halichoeres_miniatus_zanfona_1.fasta.gz
DOI: 10.5281/zenodo.15280776
title: Healthcare (Basel) Journal, An Article (Effects of Psychosocial and Ergonomic Risk Perceptions in the Hospital Environment on Employee Health, Job Performance, and Absenteeism) Dataset

description: This dataset accompanies the article "Effects of Psychosocial and Ergonomic Risk Perceptions in the Hospital Environment on Employee Health, Job Performance, and Absenteeism" published in Healthcare (Basel) journal.

The dataset contains survey responses from hospital employees regarding their perceptions of psychosocial and ergonomic risks in the workplace, and measures of health outcomes, job performance, and absenteeism. The data was collected to examine the relationships between workplace risk perceptions and employee wellbeing and productivity in healthcare settings.













The data is provided in R-compatible formats, with accompanying documentation on variable descriptions and data collection methodology.