cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.8324657
title: Blood compatibility assessments of electrospun polyurethane nanocomposites blended with megni oil for tissue engineering applications

description: Abstract: Tissue engineering holds as a prominent technique to repair or replace the damaged human parts to recreate its native function. In this research, a novel scaffold based on polyurethane (PU) comprising megni oil was electrospun for tissue engineering applications. The obtained polyurethane blended with megni oil nanofibers were characterized by scanning electron microscopy (SEM), fourier transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA), contact angle measurement and atomic force microscopy (AFM). Furthermore, the blood compatibility of the fabricated nanocomposites evaluated through activated prothrombin time (APTT), partial thromboplastin time (PT) and hemolysis assay to determine the anticoagulant nature. The morphological results showed that the fabricated nanocomposites showed reduced fiber size (789 ± 143.106 nm) than the pristine control (890 ± 116.91 nm). The interaction between PU and megni oil was identified by the hydrogen bond formation evident in the FTIR. The incorporation of megni oil in the PU decreased the wettability behavior (113.3° ± 1.528) and improved the surface roughness (646 nm). Preliminary evaluation of blood compatibility assessments was carried out using APTT, PT and hemolysis assay revealed the enhanced antithrombogenicity nature of the fabricated nanocomposites than the PU. Hence, we conclude that the fabricated new nanocomposite membrane with desirable characteristics which might find potential application in the tissue engineering applications.
DOI: 10.6084/m9.figshare.8324660
title: Pharmacognostical study of Desmodium caudatum

description: Abstract: Desmodium caudatum (Thunb.) DC, is an ever-green plant widely used in the central and southern China with great economic value for their medical values on fever, dysentery, gastroenteritis, rectal prolapse, snake bites, mastitis, and boils carbuncle. Despite its extensive uses as a traditional Chinese medicine, no systematic research on the identification of Desmodium caudatum has been reported. In this study, traditional pharmacognostical identification including the botanical origin and morphological characters, medicinal material characters, microscopic characters, physicochemical parameters determination and phytochemical screening, and DNA barcoding analysis were employed to establish an accurate and effective identification system of Desmodium caudatum. In addition, the molecular pharmacognosy study was adopted in order to identify the samples more accurately. The ITS loci of the nuclear genome and psbA-trnH loci of the chloroplast genome were selected and evaluated, which were the most variable loci. The study will be beneficial to the development of the quality standard and the identification of species.
DOI: 10.6084/m9.figshare.8324651
title: Inhibitory effect of Lonchocarpus araripensis lectin in rat acute models of inflammation

description: Abstract: Dalbergieae tribe lectins, possessing binding affinity for galactose and mannose, present inflammatory and nociceptive effects, while those for N-acetylglucosamine are anti-inflammatory. Since the anti-inflammatory effect of the seed lectin of L. araripensis (LAL) had been already demonstrated in mice, this effect was presently evaluated in rat models of acute inflammation. LAL (0.01-1 mg/kg) was administered by intravenous (i.v.) route in male Wistar rats 30 min before paw edema induction by dextran or carrageenan, and peritonitis by carrageenan. LAL (1 mg/kg) was incubated with N-acetylglucosamine for allowing lectin-sugar interactions before injection into animals. LAL toxicity was evaluated by the parameters: body mass, organs weight, stomach macroscopy, hematological and biochemical dosage. Statistical analysis was performed by ANOVA and Bonferroni’s test (p&lt;0.05). The paw edema induced by carrageenan (AUC: 0.96 ± 0.09) was inhibited by LAL about 39% (0-2 h) at all doses, and about 72% (3-5 h) at 0.1 and 1 mg/kg. The increase in the neutrophil migration stimulated by carrageenan was also inhibited by LAL (83%). In both models, LAL inhibitory effect was prevented by GlcNAc. The sub-chronic treatment with LAL was well tolerated by animals. LAL possesses anti-inflammatory effect via lectin domain, indicating potential modulator role in cellular inflammatory events.
DOI: 10.6084/m9.figshare.8324657.v1
title: Blood compatibility assessments of electrospun polyurethane nanocomposites blended with megni oil for tissue engineering applications

description: Abstract: Tissue engineering holds as a prominent technique to repair or replace the damaged human parts to recreate its native function. In this research, a novel scaffold based on polyurethane (PU) comprising megni oil was electrospun for tissue engineering applications. The obtained polyurethane blended with megni oil nanofibers were characterized by scanning electron microscopy (SEM), fourier transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA), contact angle measurement and atomic force microscopy (AFM). Furthermore, the blood compatibility of the fabricated nanocomposites evaluated through activated prothrombin time (APTT), partial thromboplastin time (PT) and hemolysis assay to determine the anticoagulant nature. The morphological results showed that the fabricated nanocomposites showed reduced fiber size (789 ± 143.106 nm) than the pristine control (890 ± 116.91 nm). The interaction between PU and megni oil was identified by the hydrogen bond formation evident in the FTIR. The incorporation of megni oil in the PU decreased the wettability behavior (113.3° ± 1.528) and improved the surface roughness (646 nm). Preliminary evaluation of blood compatibility assessments was carried out using APTT, PT and hemolysis assay revealed the enhanced antithrombogenicity nature of the fabricated nanocomposites than the PU. Hence, we conclude that the fabricated new nanocomposite membrane with desirable characteristics which might find potential application in the tissue engineering applications.
DOI: 10.6084/m9.figshare.8324660.v1
title: Pharmacognostical study of Desmodium caudatum

description: Abstract: Desmodium caudatum (Thunb.) DC, is an ever-green plant widely used in the central and southern China with great economic value for their medical values on fever, dysentery, gastroenteritis, rectal prolapse, snake bites, mastitis, and boils carbuncle. Despite its extensive uses as a traditional Chinese medicine, no systematic research on the identification of Desmodium caudatum has been reported. In this study, traditional pharmacognostical identification including the botanical origin and morphological characters, medicinal material characters, microscopic characters, physicochemical parameters determination and phytochemical screening, and DNA barcoding analysis were employed to establish an accurate and effective identification system of Desmodium caudatum. In addition, the molecular pharmacognosy study was adopted in order to identify the samples more accurately. The ITS loci of the nuclear genome and psbA-trnH loci of the chloroplast genome were selected and evaluated, which were the most variable loci. The study will be beneficial to the development of the quality standard and the identification of species.
DOI: 10.6084/m9.figshare.8324645
title: Effects of previous carbohydrate supplementation on muscular fatigue: double-blind, randomized, placebo-controlled crossover study

description: Abstract AIMS The aim of this study was to examine the effects of previous carbohydrate supplementation on high-volume resistance exercise performance METHODS Twenty males physically independent adults aged ≥18 years participated in a double-blind randomized placebo-controlled crossover study. Sixty minutes before the experimental protocol, each participant ingested 0,6 g.kg of body mass-1 of carbohydrate supplementation or placebo. Maximum voluntary isometric contraction tests were performed before and after the dynamic fatigue induction protocol consisting of 10 sets of 8 repetitions of right leg knee extensors at 120º s-1. RESULTS Lower decrement of the isometric peak torque (p&lt;0,001) and of the rate of torque development (p&lt;0,001) was observed in carbohydrate supplementation after the dynamic protocol. Both concentric and eccentric peak torque differed significantly (p&lt;0,001) between carbohydrate supplementation and placebo treatments from the second set, although the slope of the force-repetitions curve was not different between them. Additionally, the carbohydrate supplementation resulted in a lower session rating of perceived exertion (p&lt;0,05). CONCLUSIONS Previous carbohydrate supplementation attenuates muscle fatigue and internal load exercise in a high-volume isokinetic leg protocol.
DOI: 10.6084/m9.figshare.8324651.v1
title: Inhibitory effect of Lonchocarpus araripensis lectin in rat acute models of inflammation

description: Abstract: Dalbergieae tribe lectins, possessing binding affinity for galactose and mannose, present inflammatory and nociceptive effects, while those for N-acetylglucosamine are anti-inflammatory. Since the anti-inflammatory effect of the seed lectin of L. araripensis (LAL) had been already demonstrated in mice, this effect was presently evaluated in rat models of acute inflammation. LAL (0.01-1 mg/kg) was administered by intravenous (i.v.) route in male Wistar rats 30 min before paw edema induction by dextran or carrageenan, and peritonitis by carrageenan. LAL (1 mg/kg) was incubated with N-acetylglucosamine for allowing lectin-sugar interactions before injection into animals. LAL toxicity was evaluated by the parameters: body mass, organs weight, stomach macroscopy, hematological and biochemical dosage. Statistical analysis was performed by ANOVA and Bonferroni’s test (p&lt;0.05). The paw edema induced by carrageenan (AUC: 0.96 ± 0.09) was inhibited by LAL about 39% (0-2 h) at all doses, and about 72% (3-5 h) at 0.1 and 1 mg/kg. The increase in the neutrophil migration stimulated by carrageenan was also inhibited by LAL (83%). In both models, LAL inhibitory effect was prevented by GlcNAc. The sub-chronic treatment with LAL was well tolerated by animals. LAL possesses anti-inflammatory effect via lectin domain, indicating potential modulator role in cellular inflammatory events.
DOI: 10.6084/m9.figshare.8324654.v1
title: Evaluation of Gastro-protective Activity of Myristica fragrans on Ethanol-induced Ulcer in Albino Rats

description: Abstract: Myristica fragrans seeds are traditionally used to treat dyspepsia, vomiting and abdominal pain. The purpose of this study was to investigate the protective effect of Myristica fragrans in ethanol induced gastric ulcer. Study was carried out on rats, divided into four groups; negative control, positive control, standard drug control, and Myristica fragrans extract treated rats. The pH, ulcer index, acidity values and histopathological examination of stomach were evaluated. Myristica fragrans significantly (P&lt;0.05) reduced gastric lesions by 41.68% in ethanol induced ulcer model at 200 mg/kg when compared to sucralfate (60.41%). However, histopathological findings appeared similar in Myristica fragrans extract treated and standard drug control groups, where stomachs were found with mild erosion of superficial epithelium and few infiltrated inflammatory cells. pH of gastric contents of rats from extract treated was increased (4.25 ± 0.25) as compared to positive control group (2.25 ± 0.25). Ulcer index of extract treated rats was improved (41.74%). Moreover, total acidity of extract treated group (60.0 ± 0.47) was decreased as compared to control group (74.50 ± 1.04). It is concluded that Myristica fragrans showed significant protecting activity in ethanol induced ulcer. Isolation and purification of phytochemicals responsible for gastroprotective activity becomes necessary.
DOI: 10.6084/m9.figshare.8324636
title: A System to improve the management of 5G and IoT Networks by determining the Mobile Position

description: Abstract The interference in adjacent cells and the control of the boundaries have being vastly investigated since the conception of the first cell phone networks. A very large number of small cells are required for new 5G mobile networks, and therefore it is even more important to determine the correct mobile station positioning as well as the control boundaries. In order to minimize these problems, this paper proposes a simple and efficient system that improves the control of the Mobile Management Entity (MME) defined in the Release 8 of 3GPP. The system uses a tracking arrangement capable of determining the direction of the mobile station in the cell area. This information can be used to predict handover between adjacent nodes (changing of cell) minimizing a great problem, the high traffic in the backhaul network. In order to reach these goals, two or more receiver antennas are used as a Radio Direction Finder (RDF) and phase controlled directional antennas or massive multiple-input and multiple-output antennas pointing to different irradiation channels towards different directions. The theoretical section developed in this study was successfully confirmed by the experimental setup with results very closed to the developed formulation.
DOI: 10.6084/m9.figshare.8324645.v1
title: Effects of previous carbohydrate supplementation on muscular fatigue: double-blind, randomized, placebo-controlled crossover study

description: Abstract AIMS The aim of this study was to examine the effects of previous carbohydrate supplementation on high-volume resistance exercise performance METHODS Twenty males physically independent adults aged ≥18 years participated in a double-blind randomized placebo-controlled crossover study. Sixty minutes before the experimental protocol, each participant ingested 0,6 g.kg of body mass-1 of carbohydrate supplementation or placebo. Maximum voluntary isometric contraction tests were performed before and after the dynamic fatigue induction protocol consisting of 10 sets of 8 repetitions of right leg knee extensors at 120º s-1. RESULTS Lower decrement of the isometric peak torque (p&lt;0,001) and of the rate of torque development (p&lt;0,001) was observed in carbohydrate supplementation after the dynamic protocol. Both concentric and eccentric peak torque differed significantly (p&lt;0,001) between carbohydrate supplementation and placebo treatments from the second set, although the slope of the force-repetitions curve was not different between them. Additionally, the carbohydrate supplementation resulted in a lower session rating of perceived exertion (p&lt;0,05). CONCLUSIONS Previous carbohydrate supplementation attenuates muscle fatigue and internal load exercise in a high-volume isokinetic leg protocol.
DOI: 10.6084/m9.figshare.8324630
title: Two-Level Allocation for H-CRAN Architecture Based in Offloading

description: Abstract The accelerated data and apps growth represents significant challenges to the next generation of mobile networks. Amongst them, it is highlighted the necessity for a co-existence of new and old patterns during the transition of architectures. Thus, this paper has investigated solutions for offloading into a hybrid architecture, also known as H-CRAN (Heterogeneous Cloud Radio Access Network Architecture), that centralizes processing and searches a better use of the network resources. The strategy of optimization was analyzed through the evolutive algorithm PSO (Particle Swarm Optimization), in order to find a suboptimal solution to the TLA (Two-Level Allocation) in the H-CRAN architecture and another one based on FIFO (First In, First Out), for benchmarking purposes. SNR (Signal-to-noise ratio) average, Maximum Bit Rate, the number of users with or without connections and number of connections in RRHs and macro were used as performance measurements. Through the results, it was noticed an improvement of approximately 60% in the Maximum Bit Rate when compared to the traditional approach, enabling better service to the users.
DOI: 10.6084/m9.figshare.8324627
title: Multimodal Literacy and Joint Construction of Knowledge in Talk-in-Interaction

description: ABSTRACT This study aims to describe a multimodal literacy event and demonstrate how, in this event, it is possible to capture the social and interactional work of joint construction of knowledge. The talk-in-interaction segment analyzed consists in the reading of a chart in a technology lab. The sequential analysis focuses on the participants’ efforts to undertake the reading activity, revealing that the interactional segment is: a) a multimodal literacy event, in which the participants negotiate a procedure for reading an image (a graphic), in a written space other than paper (the computer screen); and b) an instance of joint construction of knowledge, considering that the participants develop a satisfactory reading procedure for their situated purposes, which enables them to obtain with some precision the information they are seeking.
DOI: 10.6084/m9.figshare.8324630.v1
title: Two-Level Allocation for H-CRAN Architecture Based in Offloading

description: Abstract The accelerated data and apps growth represents significant challenges to the next generation of mobile networks. Amongst them, it is highlighted the necessity for a co-existence of new and old patterns during the transition of architectures. Thus, this paper has investigated solutions for offloading into a hybrid architecture, also known as H-CRAN (Heterogeneous Cloud Radio Access Network Architecture), that centralizes processing and searches a better use of the network resources. The strategy of optimization was analyzed through the evolutive algorithm PSO (Particle Swarm Optimization), in order to find a suboptimal solution to the TLA (Two-Level Allocation) in the H-CRAN architecture and another one based on FIFO (First In, First Out), for benchmarking purposes. SNR (Signal-to-noise ratio) average, Maximum Bit Rate, the number of users with or without connections and number of connections in RRHs and macro were used as performance measurements. Through the results, it was noticed an improvement of approximately 60% in the Maximum Bit Rate when compared to the traditional approach, enabling better service to the users.
DOI: 10.6084/m9.figshare.8324636.v1
title: A System to improve the management of 5G and IoT Networks by determining the Mobile Position

description: Abstract The interference in adjacent cells and the control of the boundaries have being vastly investigated since the conception of the first cell phone networks. A very large number of small cells are required for new 5G mobile networks, and therefore it is even more important to determine the correct mobile station positioning as well as the control boundaries. In order to minimize these problems, this paper proposes a simple and efficient system that improves the control of the Mobile Management Entity (MME) defined in the Release 8 of 3GPP. The system uses a tracking arrangement capable of determining the direction of the mobile station in the cell area. This information can be used to predict handover between adjacent nodes (changing of cell) minimizing a great problem, the high traffic in the backhaul network. In order to reach these goals, two or more receiver antennas are used as a Radio Direction Finder (RDF) and phase controlled directional antennas or massive multiple-input and multiple-output antennas pointing to different irradiation channels towards different directions. The theoretical section developed in this study was successfully confirmed by the experimental setup with results very closed to the developed formulation.
DOI: 10.6084/m9.figshare.8324621
title: Antibacterial and cytotoxicity activities and phytochemical analysis of three ornamental plants grown in Mexico

description: Abstract: This study evaluates the antibacterial, cytotoxic activities, and phytochemical composition, of Callistemon citrinus, Hibiscus rosa-sinensis and Plumbago auriculata leaves and flowers, three ornamental plants in Mexico. However, in other countries offers a range of other uses. Ethanol extracts of C. citrinus leaf and flower presented stronger antibacterial activity than the extracts obtained from the other two plants. C. citrinus leaf showed low cytotoxicity (LC50 &lt;600 µg/mL) on the brine shrimp test, whereas the ethanol extracts of H. rosa-sinensis and P. auriculata leaves showed no cytotoxic activity. Flower extracts obtained from the three plants did no exhibit cytotoxicity. GC-MS analysis revealed that the ethanol extract of P. auriculata leaf contained lupeol triterpene and lupeol acetate, neither of them have been previously reported in this genus. Gamma sitosterol was present in the leaf and flower extracts of P. auriculata. Higher contents of linoleic and linolenic acids were found in extracts of H. rosa-sinensis leaves and flowers. The ability of the ethanol extracts of C. citrinus leaves and flowers to inhibit the growth of Gram-positive and Gram-negative bacteria indicates a potentially broad antimicrobial spectrum. Moreover, the absence of cytotoxicity suggests the potential use of this plant to treat microbial infections.
DOI: 10.6084/m9.figshare.8324624
title: Correlation of Cervical Cancer Mortality with Fertility, Access to Health Care and Socioeconomic Indicators

description: Abstract Objective The present study aimed to examine which development indicators are correlated with cervical cancer (CC) mortality rates in Brazil. Methods This was an ecological study that correlatedmortality rates and indicators, such as human development index (HDI), gross domestic product (GDP) per capita, illiteracy rate, fertility rate, screening coverage, proportion of private health insurance use, density of physicians, and density of radiotherapy centers. Themortality rateswere obtained fromthe Brazilian national registry, while the indicators were based on official reports from the Ministry of Health. Univariate and multivariate linear regression was used. Results Among the states of Brazil, the average age-specific CC mortality rate from 2008 to 2012 varied from 4.6 to 22.9 per 100,000 women/year. In the univariate analysis, HDI, proportion of private health insurance use, density of physicians, and density of radiotherapy centers were inversely correlated with the mortality rates. Fertility rate was positively correlated with the mortality rates. In the multivariate analysis, only fertility rate was significantly associated with the CC mortality rate (coefficient of correlation: 9.38; 95% confidence interval [CI]: 5.16-13.59). Conclusion A decrease in the fertility rate, as expected when the level of development of the regions increases, is related to a decrease in the mortality rate of CC. The results of the present study can help to better monitor the quality assessment of CC programs both among and within countries.
DOI: 10.6084/m9.figshare.8324627.v1
title: Multimodal Literacy and Joint Construction of Knowledge in Talk-in-Interaction

description: ABSTRACT This study aims to describe a multimodal literacy event and demonstrate how, in this event, it is possible to capture the social and interactional work of joint construction of knowledge. The talk-in-interaction segment analyzed consists in the reading of a chart in a technology lab. The sequential analysis focuses on the participants’ efforts to undertake the reading activity, revealing that the interactional segment is: a) a multimodal literacy event, in which the participants negotiate a procedure for reading an image (a graphic), in a written space other than paper (the computer screen); and b) an instance of joint construction of knowledge, considering that the participants develop a satisfactory reading procedure for their situated purposes, which enables them to obtain with some precision the information they are seeking.