cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.12061668.v1
title: Observation reports of acid rain collected on Mt. Tateyama (2019)

description: 富山市科学博物館では、2003年から立山有料道路沿いにおける酸性雨観測を開始し、標高別に降水中のイオン濃度、pH、電気伝導度、粒子個数濃度（粒子個数濃度の測定は2012年より開始）の挙動をモニタリングしてきた。本報告では、2019年の観測結果について報告する。<br>
DOI: 10.6084/m9.figshare.21617931.v1
title: Supplementary Material for: Flow Cytometry Analysis Reveals a Wide Cytologic and Immunophenotypic Spectrum of Peripheral B Lymphocytes in Angioimmunoblastic T-Cell Lymphoma

description: <b><i>Introduction:</i></b> Angioimmunoblastic T-cell lymphoma (AITL) is an aggressive T-cell lymphoma commonly associated with B-cell dysregulation. Correlations involving B-cell dysregulation and clinicopathological features remain unclear. <b><i>Methods:</i></b> We prospectively collected blood samples from 11 AITL patients and 17 healthy controls. The percentages of B-cell subpopulations and lymphocytes with IL-21 production were assessed using flow cytometry. Peripheral blood lymphocyte morphology was evaluated microscopically. <b><i>Results:</i></b> Six of 11 (54.5%) patients presented with polyclonal hypergammaglobulinemia. Three of 11 (27.3%) tumor biopsies showed monoclonal immunoglobulin gene rearrangement. The patients exhibited significantly lower levels of naive (<i>p</i> &lt; 0.001) and class-switched (<i>p</i> &lt; 0.001) B cells than controls. The percentages of IgD−CD27− B cells (<i>p</i> = 0.007) and antibody-secreting cells (ASCs) (<i>p</i> = 0.001) were increased. Blood smears revealed atypical lymphocytes and immature plasma cells with morphological diversity. In comparison to normal controls, IL-21 production significantly increased in CD4+ (<i>p</i> &lt; 0.001) and CD8+ (<i>p</i> = 0.020) T cells. B-cell clonality, <i>RHOA</i> G17V mutation, and the presence of sheets of clear cells and immature/mature plasma cells in lymph nodes were significantly associated with percentages of class-switched B cells and ASCs. The patients with circulating EBV DNA had a lower percentage of naive B cells (<i>p</i> = 0.009). <b><i>Conclusions:</i></b> Our results demonstrated a wide spectrum of peripheral B-cell morphologies and immunophenotypes of peripheral B cells in AITL. These findings correspond to dysregulated B-cell immunity and heterogeneous clinicopathological features.
DOI: 10.6084/m9.figshare.11926812.v1
title: SaccadesDataset.csv

description: Saccadic records from ataxia patients and control individuals
DOI: 10.6084/m9.figshare.14258297.v1
title: Supplementary Material for: The Prognostic Value of Left Atrial Global Longitudinal Strain and Left Atrial Phasic Volumes in Patients Undergoing Transcatheter Valve Implantation for Severe Aortic Stenosis

description: <b><i>Introduction:</i></b> The changes and the prognostic implications of left atrial (LA) volumes (LAV), LA function, and vascular load in patients undergoing transcatheter aortic valve implantation (TAVI) for severe aortic stenosis (AS) are less known. <b><i>Methods:</i></b> We enrolled 150 symptomatic patients (mean age 82 ± 8 years, 58% female, and pre-TAVI aortic valve area 0.40 ± 0.19 cm/m<sup>2</sup>) with severe AS who underwent 2D transthoracic echocardiography and 2D speckle tracking echocardiography at average 21 ± 35 days before and 171 ± 217 days after TAVI. The end point was a composite of new onset of atrial fibrillation, hospitalization for heart failure and all-cause death (major adverse cardiac events [MACE]). <b><i>Results:</i></b> After TAVI, indexed maximal LA volume and minimum volume of the LA decreased by 2.1 ± 10 mL/m<sup>2</sup> and 1.6 ± 7 mL/m<sup>2</sup> (<i>p</i> = 0.032 and <i>p</i> = 0.011, respectively), LA function index increased by 6.8 ± 11 units (<i>p</i> &lt; 0.001), and LA stiffness decreased by 0.38 ± 2.0 (<i>p</i> = 0.05). No other changes in the LA phasic volumes, emptying fractions, and vascular load were noted. Post-TAVI, both left atrial and ventricular global peak longitudinal strain improved by about 6% (<i>p</i> = 0.01 and 0.02, respectively). MACE was reached by 37 (25%) patients after a median follow-up period of 172 days (interquartile range, 20–727). In multivariable models, MACE was associated with both pre- and post-TAVI LA global peak longitudinal strain (hazard ratio [HR] 0.75, CI 0.59–0.97; and HR 0.77, CI 0.60–1.00, per 5 percentage point units, respectively), pre-TAVI LV global endocardial longitudinal strain (HR 1.37, CI 1.02–1.83 per 5 percentage point units), and with most of the LA phasic volumes. <b><i>Conclusion:</i></b> Within 6 months after TAVI, there is reverse LA remodeling and an improvement in LA reservoir function. Pre- and post-TAVI indices of LA function and volume remain independently associated with MACE. Larger studies enrolling a greater diversity of patients may provide sufficient evidence for the utilization of these imaging biomarkers in clinical practice.
DOI: 10.6084/m9.figshare.19672710.v2
title: Ambrosia artemisiifolia annotations GFF

description: Ambrosia artemisiifolia phased diploid genome gene annotations for haplotype 1 (NCBI BioProject ID PRJNA929657).
DOI: 10.6084/m9.figshare.26384968.v1
title: Supplementary Material for: Ultrasound guidance to replicate transuterine BioGlue injection in the fetal hydrocephalus sheep model

description: Introduction: Congenital hydrocephalus often results in irreversible and severe damage to the brain despite postnatal interventions. The potential for prenatal intervention to mitigate these deleterious effects underscores the importance of a suitable animal model. We aimed assess the results of an ultrasound guided transuterine approach to replicate the BioGlue injection fetal hydrocephalus model. 
Methods: Pregnant ewes were anesthetized at 95 days of gestation and BioGlue was injected into the fetal cisterna magna under ultrasound guidance through the uterus. Ventriculomegaly was assessed by MRI and histology. 
Results: Nine pregnant ewes were included in the study, and their fetuses were divided into the the BioGlue intervention group (n=9 fetuses) or the control group (n=7 fetuses) who were not injected. Although hydrocephalus was noted in 5 of 9 fetuses in the intervention group, the ability to induce hydrocephalus went from 0% to 100% in the last 3 fetuses following technical modifications. None of the controls developed hydrocephalus. Fetal brains with hydrocephalus demonstrated increased IBA1+ compared to control animals. 
Conclusions: While technical challenges were noted, the ultrasound guided transuterine approach to replicate the BioGlue fetal hydrocephalus model in sheep showed consistent and reproducible results. This model offers the advantage of directly visualizing the location of the needle tip and injection of the BioGlue. This technique offers an alternative for testing novel approaches for prenatal congenital hydrocephalus treatment.
DOI: 10.6084/m9.figshare.5241796.v1
title: Erratum: Human Dental Pulp Stem Cells via the NF-κB Pathway

description: <b><i>Background/Aims: </i></b>Odontogenic differentiation of human dental pulp stem cells (HDPSCs) is regulated by multiple factors and signaling molecules. However, their regulatory mechanisms are not completely understood. In this study, we investigated the role of Zinc finger and BTB domain-containing 20 (ZBTB20) in odontoblastic differentiation of HDPSCs. <b><i>Methods: </i></b>HDPSCs were obtained from human third molars and ZBTB20 expression was examined by qRT-PCR and western blot. Their osteo/odontogenic differentiation and the involvement of NF-κB pathway were subsequently investigated. <b><i>Results: </i></b>The expression of ZBTB20 is upregulated in a time-dependent manner during odontogenic differentiation of hDPSCs. Inhibition of ZBTB20 reduced osteogenic medium (OM)-induced odontogenic differentiation, reflected in decreased alkaline phosphatase (ALP) activity, mineralized nodule formation and mRNA expression of odonto/osteogenic marker genes. In contrast, overexpression of ZBTB20 enhanced ALP activity, mineralization and the expression of differentiation marker genes. Furthermore, the expression of IκBa was increased by ZBTB20 silencing in HDPSCs, whereas ZBTB20 overexpression decreased IκBa and enhanced nuclear NF-κB p65. Inhibition of the NF-κB pathway significantly suppressed the odontogenic differentiation of HDPSCs induced by ZBTB20. <b><i>Conclusion: </i></b>This study shows for the first time that ZBTB20 plays an important role during odontoblastic differentiation of HDPSCs and may have clinical implications for regenerative endodontics.
DOI: 10.6084/m9.figshare.14273312.v1
title: Flow Data.xlsx

description: This is the flow data from the model simulation and the observation data used for validation
DOI: 10.6084/m9.figshare.12673217.v2
title: Our World in Data COVID-19 Testing Database

description: This new database brings together official data on the extent of PCR testing over time for 94 countries. We provide a time series for the daily number of tests performed, or people tested, together with metadata describing data quality and comparability issues needed for the interpretation of the time series. The database is updated regularly through a combination of automated scraping and manual collection and verification, and is entirely replicable, with sources provided for each observation. In providing accessible cross-country data on testing output, it aims to facilitate the incorporation of this crucial information into epidemiological studies, as well as track a key component of countries’ responses to COVID-19.<br>A live version of the database, which continues to be updated, is available at the authors' website (https://ourworldindata.org/covid-testing) and can also be downloaded from a public GitHub repository (https://github.com/owid/covid-19-data/tree/master/public/data/testing).
DOI: 10.6084/m9.figshare.22634395.v1
title: Single-nucleus RNA-sequencing anslysis of PFC from human.

description: Brain aging is accompanied by a decline and loss of cognitive and learning memory, and is associated with many neurodegenerative diseases, thus posing a significant threat to global health. There are no systematic studies on the single-cell level of human brain aging to explain cell-specific transcriptomic changes. Here, by integrating two independent single-nucleus transcriptome sequencing (snRNA-seq) data of human prefrontal cortex tissue, we found that the prefrontal cortex has highly cellular heterogeneity during aging. The findings showed significantly reduced excitatory neurons during aging in healthy individuals. However, the number of microglia and oligodendrocytes were significantly increased. We compared levels of gene expression in cells across all stage by cell type, and identified 93 unique differentially expressed genes (DEGs) that implicated all major cell types. All or most of DEGs in oligodendrocyte, OPC, microglia, excitatory, and inhibitory neurons were downregulated, whereas most DEGs in astrocytes, and endotheliocyte were upregulated.
DOI: 10.6084/m9.figshare.26362141.v1
title: Organelle assembly graph

description: The assembly graph files of organelle genomes generated using TIPP_plastid, PMAT, ptGAUL, and CLAW.
DOI: 10.6084/m9.figshare.1088258.v5
title: Persistent gamma oscillations in vitro: Utah array data from macaque temporal cortex

description: The zip file contains a 21-second segment of a Utah array recording from macaque temporal neocortex in vitro (data collected by Matt Ainsworth), saved as a .mat file. Nanomolar kainate solution was applied to induce persistent gamma oscillations. Data sampled at 10kHz. The raw data are included, organised into a 100 by 210000 matrix (100 channels, 210000 samples per channel). For description of the experimental setup and array placement, see Tomsett et al. 2014 (link below, open access - if you use this data in a publication, please cite that paper!).<br><br>The zip file also contains a matlab script to analyse the data and reproduce figure 9A from that paper. This script performs several filtering and normalisation operations on the data. It requires the Matlab Signal Processing Toolbox to work.<br><br>EDIT: updated the analysis file; original uplaod did not band-pass filter the data<br>
DOI: 10.6084/m9.figshare.16457001.v2
title: List of questions and description of the questionnaire-Teaching learning behavior in medicine according to students' perspective

description: This questionnaire consists of 33 items based on a part of the dissertation, have gone psychometric properties test and validity by CFA.
DOI: 10.6084/m9.figshare.7981976.v2
title: Dataset for "Enhanced propagation of motile bacteria on surfaces due to forward scattering"

description: Dataset associated with "Enhanced propagation of motile bacteria on surfaces due to forward scattering"
DOI: 10.6084/m9.figshare.21941249.v1
title: Supplementary Material for: Transition of Extremely Preterm Infants from Birth to Stable Breathing: A Secondary Analysis of the CORSAD Trial

description: <b><i>Objective:</i></b> Exploratory secondary analysis of the CORSAD trial compared a new resuscitation system (rPAP) to the standard T-piece system. This analysis focused on the subgroup of infants who were not intubated in the delivery room. The aim was to compare the use of noninvasive positive pressure ventilation (PPV), oxygen saturation, and Apgar scores for the two resuscitation systems during the 30-min intervention period. <b><i>Methods:</i></b> This is secondary analysis of CORSAD trial using data from the intervention period in the delivery room. Infants in the original randomized system groups were divided into intubated and nonintubated groups. For nonintubated breathing infants, we compared demographics, the use of PPV, Apgar scores, and oxygen saturation at 5 and 10 min after birth. Generalized linear models were applied to calculate the risk difference and odds ratio with 95% CI between the two groups. <b><i>Results:</i></b> Among nonintubated infants, the use of PPV repeatedly (defined as PPV with at least 1 min of spontaneous breathing between PPV cycles) was less frequent in the rPAP group (26.8% vs. 43.3%, %RD −16.5, 95% CI [−31.7 to −1.1], <i>p</i> 0.04). The use of PPV after 5 min of age was also less common in the rPAP group (23.2% vs. 38.8%, %RD −15.6, 95% CI [−30.7 to −0.8], <i>p</i> 0.04). There were no statistically significant differences in Apgar scores or oxygen saturation levels between the groups. <b><i>Conclusion:</i></b> In the CORSAD trial, less PPV was needed to establish stable breathing in extremely preterm infants using the rPAP compared to using the standard T-piece without significant difference in Apgar scores or oxygenation.
DOI: 10.6084/m9.figshare.4047414.v1
title: Supplementary Material for: Inhibition of Pathogenic Mutant SOD1 Aggregation in Cultured Motor Neuronal Cells by Prevention of Its SUMOylation on Lysine 75

description: <br>Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by the selective death of motor neurons. Mutations in the <i>SOD1 </i>gene encoding the superoxide dismutase 1 are present in 15% of familial ALS cases and in 2% of sporadic cases. These mutations are associated with the formation of SOD1-positive aggregates. The mechanisms of aggregation remain unknown, but posttranslational modifications of SOD1 may be involved. Here, we report that NSC-34 motor neuronal cells expressing mutant SOD1 contained aggregates positive for small ubiquitin modifier-1 (SUMO-1), and in parallel a reduced level of free SUMO-1. CLEM (correlative light and electron microscopy) analysis showed nonorganized cytosolic aggregates for all mutations tested (SOD1<sup>A4V</sup>, SOD1<sup>V31A</sup>, and SOD1<sup>G93C</sup>). We next show that preventing the SUMOylation of mutant SOD1 by the substitution of lysine 75, the SUMOylation site of SOD1, significantly reduces the number of motor neuronal cells with aggregates. These results support the need for further research on the SUMOylation pathways, which may be a potential therapeutic target in ALS.
DOI: 10.6084/m9.figshare.19403651.v1
title: Supplementary Material for: Integrin αⅤ mediates the effects of irisin on human mature adipocytes

description: Medicine
DOI: 10.6084/m9.figshare.28228532.v1
title: Chromosome-level genome sequencing and assembly of the parasitoid wasp Leptopilina myrica

description: This dataset contains the genome assembly and annotation of <i>Leptopilina myrica.</i>
DOI: 10.6084/m9.figshare.21371469.v1
title: Nitrogen fertilizers use in China from 1952 to 2018

description: The annual N fertilizers use dataset in China at 5 km × 5 km resolution covering the period of 1952 to 2018. Unit: g N m-2 yr-1. Format: ENVI/IDL data file format.
DOI: 10.6084/m9.figshare.5248468.v1
title: Two-dimensional Fracture Modeling with the Generalized/Extended Finite Element Method: An Object-Oriented Programming Approach - Supporting Materials.

description: Code and additional files to solve 2D solid mechanics problems using an OOP-based in-house code, called INSANE.<br>This code helps to reproduce the results shown in the paper:Two-dimensional Fracture Modeling with the Generalized/Extended Finite Element Method: An Object-Oriented Programming Approach. Advances in Engineering Software (under review), 2017.<br>
DOI: 10.6084/m9.figshare.25435681.v1
title: Training Dataset for FeatureLTE: Binary Classification

description: Training datasets for the binary classification task of FeatureLTE.
DOI: 10.6084/m9.figshare.853811.v1
title: Psicología de la Comunicación

description: Apunts utilizados para la asignatura Psicologia de la Comunicación
DOI: 10.6084/m9.figshare.28744208.v1
title: Workshop resources

description: Workshop Resources:<br>1. MEPA Workshop Application2. Code of conduct<br>3. Field Waiver4. Participant emails (sent pre-workshop to establish expectations and communicate logistics)<br>5. MEPA Workshop Equipment List and Budget<br>6. MEPA Workshop Evaluation (English)<br>7. MEPA Workshop Evaluation (Español)
DOI: 10.6084/m9.figshare.5306482.v1
title: Result.xlsx

description: An urban energy system
DOI: 10.6084/m9.figshare.22290787.v1
title: Data and wilcoxon tests.xlsx

description: The excel file compiles the number and frequency of words and terms related to digitalization and remote working found in the annual reports (ARs) of 173 UK banks from 2018-2020. Annual reports are downloaded from home websites of the banks. Wilcoxon signed-rank test and sentiment analysis are utilized to test whether COVID-19 has significantly impacted the word frequencies pertained to digitalization and RW in ARs of 173 banks in the UK from 2018 to 2020.
DOI: 10.6084/m9.figshare.25449472.v1
title: Supplementary Material for: Diagnosis value of the blood urea nitrogen to creatinine ratio in determining the need for intervention of acute upper gastrointestinal bleeding

description: Introduction: The blood urea nitrogen (BUN) to creatinine (Cr) ratio (BUN/Cr ratio) may be used to evaluate the need for intervention of acute upper gastrointestinal bleeding (AUGIB). This study aimed to explore the predictive value of the BUN/Cr ratio in the need for intervention of AUGIB.
Methods: This retrospective observational study included patients with AUGIB in the hospital's emergency department between August 2019 and May 2023. The patients were grouped according to whether they underwent an intervention for AUGIB. Patients treated between August 2019 and May 2022 were selected as the training set and the others as the validation set.
Results: A total of 466 patients (328 males, 138 females) with AUGIB were enrolled in the intervention group (n=167) and the no-intervention group (n=299). In the training set, multivariable logistic regression showed that the BUN/Cr ratio (OR: 1.013, 95%CI: 1.003-1.023, P=0.009), hemoglobin (OR: 0.989, 95%CI: 0.981-0.997, P=0.010), and a previous history of esophageal variceal bleeding (OR: 6.898, 95%CI: 3.989-11.929, P&lt;0.001) were independently associated with intervention for AUGIB. The area under receiver operating characteristic curve of BUN/Cr ratio and the prediction model based on logistic regression to predict the need for intervention of AUGIB were 0.604 (95%CI: 0.544-0.664) and 0.759 (95%CI: 0.706-0.812) in the training set and 0.634 (95%CI: 0.529, 0.740) and 0.708 (95% CI: 0.609, 0.806) in the validation set, respectively.
Conclusion: The BUN/Cr ratio was associated with the need for AUGIB intervention. Combining it with other parameters might improve its diagnostic value to predict the need for intervention of AUGIB.
DOI: 10.6084/m9.figshare.27018988.v1
title: supplementary materials for "<b>Early Paleozoic large-scale subduction retreat and slab rollback revealed by mafic arc magmas in the southern Central Asian Orogenic Belt</b>"

description: The northern margin of the Tarim-North China collage features Early Paleozoic arc magmas, rifted terrains, and back-arc basins, yet their tectonic implications remain unclear. Mafic arc magmas may provide critical constraints on the thermal state of subducted slabs and subduction zone dynamics. This study explores the origins and large-scale significance of these magmas, concentrating on mafic rocks in NW China. Findings show they formed at 450 - 420 Ma and are geochemically resemble high-Al arc basalts. The magmas result from melting of sediment melt metasomatized mantle, followed by fractional crystallization of various minerals. The findings, integrated with regional data, reveal a continental arc over 1,500 km along the collage's northern margin, with prevalent slab-derived sediment melts in the sub-arc mantle wedge, indicating high slab surface temperatures (SST). This elevated SST likely arises from asthenosphere upwelling due to slab rollback, which is also responsible for the rifting of marginal terrains and the formation of back-arc basins along the northern edge of the collage. Furthermore, this retreating-type accretionary orogenic belt may globally interconnect to create a subduction girdle, thereby facilitating prolonged dispersal of Gondwana, drift and reunion of its derived continents in Asia, and the opening of the Paleo-Tethys.
DOI: 10.6084/m9.figshare.21944087.v1
title: Under what circumstances can the forest sector contribute to 2050 climate change mitigation targets ? A study from forest ecosystems to landfill methane emissions for the province of Quebec, Canada.

description: Datasets used in Under what circumstances can the forest sector contribute to 2050 climate change mitigation targets ? A study from forest ecosystems to landfill methane emissions for the province of Quebec, Canada.
DOI: 10.6084/m9.figshare.21532893.v1
title: MS1(POS+NEG+QC)

description: The file name A represents the negative ion modes of MS1 in idiopathic membranous nephropathy (IMN) group and A (1) represents the positive ion modes of MS1 in IMN group. The file name N represents the negative ion modes of MS1 in healthy control (HC) group and N(1) represents the positive ion modes of MS1 in HC group. The file name QC represents the quality control of negative ion modes in two groups and QC(1) represents the quality control of positive ion modes in two groups.
DOI: 10.6084/m9.figshare.10048055.v1
title: code

description: Code to analyze the datasets in this project