cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.5129920
title: Supplementary Material for: Kognitiv-psychoedukative Therapie im Vergleich zu Bibliotherapie bei bipolarer Störung: Eine kontrollierte Gruppentherapiestudie

description: <b><i>Hintergrund:</i></b> Kognitive Verhaltenstherapie wird als zusätzlich wirksam zur medikamentösen Therapie in der Rückfallprophylaxe bei bipolaren Störungen angesehen. Es gibt bisher allerdings nur wenige Untersuchungen zu Therapien mit deutschsprachigen Therapiemanualen. <b><i>PatientInnen und Methoden:</i></b> In einer kontrollierten Gruppentherapiestudie für bipolare PatientInnen wurde die Wirksamkeit der kognitiv-psychoedukativen Therapie (KPT) nach dem Therapiemanual von Schaub et al. [2004] im Vergleich zu einer Bibliotherapie (BT) auf die Rückfallhäufigkeit hin untersucht. <b><i>Ergebnisse:</i></b> Insgesamt wurden 100 medizierte PatientInnen über 14 Wochen behandelt, 52 in der KPT-Gruppe und 48 in der BT-Gruppe. 12 Monate nach Beginn der Studie schnitten in der Globalbeurteilung nach der Clinical Global Impression (CGI)-Skala die PatientInnen der KPT-Gruppe signifikant besser ab als die der BT-Gruppe. In beiden Gruppen zeigt sich eine signifikante Reduktion der Anzahl der Krankheitsepisoden (in der BT-Gruppe allerdings nur für die manischen Episoden) und der Anzahl und Dauer stationärer Krankenhausaufenthalte. Außerdem konnten in beiden Gruppen positive Auswirkungen auf Krankheitskonzepte und eine Reduktion psychosozialer Beeinträchtigungen gezeigt werden. <b><i>Schlussfolgerungen:</i></b> Beide Therapieformen sind wirksam in der Vorbeugung manischer Episoden, während nur die KPT-Gruppe auch einen Einfluss auf die Verhinderung depressiver Episoden sowie insgesamt eine höhere Wirksamkeit zeigte.
DOI: 10.6084/m9.figshare.5129908
title: Supplementary Material for: A 13-Year Retrospective Study on Primary Liver Cancer in Cambodia: A Strikingly High Hepatitis C Occurrence among Hepatocellular Carcinoma Cases

description: <b><i>Objectives:</i></b> Hepatocellular carcinoma (HCC) is the main type of primary liver cancer (PLC) worldwide, but cholangiocarcinoma (CCA) may be predominant in some specific regions of Southeast Asia. The aim of the present study was to delineate a pattern of Cambodian PLC patients attending the Calmette Hospital in the Cambodian capital Phnom Penh. <b><i>Materials and Methods:</i></b> A total of 553 medical charts diagnosing PLCs from January 2003 to May 2015 were obtained from both the Oncology and Hepato-Gastroenterology Departments of the Calmette Hospital. <b><i>Results:</i></b> HCC was the predominant type of PLC recorded, with 511 cases (92.4%), whereas CCA represented merely 7.6% (42 cases) of the overall series. Hepatitis B virus (HBV; 44.3%) and hepatitis C virus (HCV; 43%) infection rates were similar among the HCC patients, while small subsets of CCA patients were infected with HBV (15.4%) or HCV (11.5%). Most HCC (84%) and CCA (73.8%) patients received palliative treatment only. <b><i>Conclusion:</i></b> The present study indicates that HCC is the main form of primary hepatic neoplasm among PLC patients attending a hospital in Cambodia. HBV and HCV infections represented equivalent burdens and major contributing factors to HCC. Therefore, the implementation of prevention programs for these infectious agents should become a priority for health policy makers in the country.
DOI: 10.6084/m9.figshare.5129911
title: Supplementary Material for: Ressourcenaktivierung durch Perspektivwechsel. Stehen Sie doch einfach einmal auf! Ein Plädoyer für mehr Bewegung(en) in der Verhaltenstherapie

description: <b><i>Hintergrund:</i></b> Im Zustand emotionaler Aktivierung sind die Patienten in ihrem ich-syntonen Störungsattraktor fixiert. Mentale Perspektivwechsel haben eine zentrale Bedeutung für kognitive Neubewertungen. Durch körperliche Perspektivwechsel könnten vermutlich der Wechsel in andere Aktivierungszustände und die Aktivierung latent vorhandener Ressourcen im Sinne einer vertikalen Integration verschiedener Modalitäten umfassend unterstützt werden. <b><i>Methode:</i></b> Zehn teilweise aufeinander aufbauende Techniken mit verschiedenen Arten von Perspektivwechseln zum kontrollierten Balancieren zwischen emotionaler Aktivierung und Desidentifikation sowie Neubewertung werden dargestellt. Der Kontext ihrer Herkunft wird umrissen. <b><i>Ergebnis:</i></b> Diese komplexen Techniken ermöglichen in sehr dynamischer Weise die Aktivierung und Modifikation von Erlebens- und Verhaltensmustern, ohne die therapeutische Beziehung zu belasten. <b><i>Schlussfolgerung:</i></b> Diese Techniken der Beziehungsgestaltung und Prozesssteuerung könnten vermutlich unabhängig vom Störungsmodell bereits in der Therapieausbildung vermittelt werden.
DOI: 10.6084/m9.figshare.5129914
title: Supplementary Material for: Proliferation and Migration of Peripheral Retinal Pigment Epithelial Cells Are Associated with the Upregulation of Wingless-Related Integration and Bone Morphogenetic Protein Signaling in Dark Agouti Rats

description: <b><i>Objective:</i></b> The aim of this study was to investigate the possible migration of proliferating peripheral retinal pigment epithelial (RPE) cells and their association with differential gene expressions. <b><i>Materials and Methods:</i></b> The RPE layer was obtained from the inner aspect of the eyeball of dark agouti rats (12-13 weeks old) and was mounted on glass slides. The peripheral RPE cell proliferation was evaluated using bromodeoxyuridine immunohistochemistry (n = 10). The cell migration was examined using the Dil tracer technique (n = 40) at the end of weeks 6, 10, 14 and 18. Affymetrix microarray analysis was used to investigate differential gene expressions in peripheral and central RPE cells, which was authenticated by RT-PCR using 4 RPE-specific genes (n = 10). <b><i>Results:</i></b> In this study, peripheral RPE cells divided and appeared in clusters, but equatorial and central RPE cells rarely divided. The peripheral RPE cells migrated to the central RPE region in a time-dependent manner up to the end of week 14, but not later. The microarray analysis showed the expression of 9,645 out of a total of 35,220 genes studied. Among the 9,645 genes, 573 were differentially expressed (438 were upregulated and 135 were downregulated) in peripheral RPE cells as compared to central RPE cells. Of these 573 genes, 56 were associated with signaling pathways related to the regulation of cell proliferation, including Pax6, TGFβ, BMP and Wnt, and 404 were associated with pathways of cell migration. <b><i>Conclusions:</i></b> In this study,<b> </b>peripheral RPE cells divided and migrated to the central region. This process was associated with differential gene expressions in these cells.
DOI: 10.6084/m9.figshare.5129917
title: Supplementary Material for: Best Albuminuria Measurement to Predict Cardiovascular and Renal Events

description: <b><i>Background:</i></b> Kidney Disease Improving Global Outcomes (KDIGO) guidelines encourage clinicians to estimate 24-hour albuminuria as albumin to creatinine ratio (ACR) from spot urine samples. However, ACR underestimates 24-hour albumin excretion in muscular individuals. Equations that adjust ACR for surrogates of muscle mass to yield an estimated albumin excretion rate (eAER) were developed. We hypothesised that eAER is a better predictor of cardiovascular and renal outcomes than ACR. <b><i>Methods:</i></b> We determined ACR and eAER among 443 patients with chronic kidney disease G2-G4 recruited into the CARE FOR HOMe study. Patients were classified into KDIGO albuminuria categories, and followed for cardiovascular and renal events. The primary analysis was the net reclassification improvement (NRI) for those with and without events within 3 years of follow-up. <b><i>Results:</i></b> Eighty five patients experienced cardiovascular events during 3 years of follow-up, 13 of whom were reclassified to a more advanced albuminuria category, and 1 patient to a less advanced category by eAER compared to ACR (NRI<sub>event</sub>: 14.1% (95% CI 5.8-22.4)). Among 358 patients without a cardiovascular event, 17 patients were reclassified to a more advanced albuminuria category, and 2 patients to a less advanced category by eAER (NRI<sub>no event</sub>: -4.2%, 95% CI -8.5 to -1.8). Sixty patients went through renal events, and 383 patients had event-free 3-year follow-up. NRI<sub>event</sub> was 6.7% (95% CI -1.2 to 14.5), and NRI<sub>no event</sub> was -6.0% (95% CI -10.6 to 3.4) for renal events. <b><i>Conclusion:</i></b> Compared to ACR albuminuria categories, eAER categories are better associated with future cardiovascular events, but not with renal events.
DOI: 10.6084/m9.figshare.5129920.v1
title: Supplementary Material for: Kognitiv-psychoedukative Therapie im Vergleich zu Bibliotherapie bei bipolarer Störung: Eine kontrollierte Gruppentherapiestudie

description: <b><i>Hintergrund:</i></b> Kognitive Verhaltenstherapie wird als zusätzlich wirksam zur medikamentösen Therapie in der Rückfallprophylaxe bei bipolaren Störungen angesehen. Es gibt bisher allerdings nur wenige Untersuchungen zu Therapien mit deutschsprachigen Therapiemanualen. <b><i>PatientInnen und Methoden:</i></b> In einer kontrollierten Gruppentherapiestudie für bipolare PatientInnen wurde die Wirksamkeit der kognitiv-psychoedukativen Therapie (KPT) nach dem Therapiemanual von Schaub et al. [2004] im Vergleich zu einer Bibliotherapie (BT) auf die Rückfallhäufigkeit hin untersucht. <b><i>Ergebnisse:</i></b> Insgesamt wurden 100 medizierte PatientInnen über 14 Wochen behandelt, 52 in der KPT-Gruppe und 48 in der BT-Gruppe. 12 Monate nach Beginn der Studie schnitten in der Globalbeurteilung nach der Clinical Global Impression (CGI)-Skala die PatientInnen der KPT-Gruppe signifikant besser ab als die der BT-Gruppe. In beiden Gruppen zeigt sich eine signifikante Reduktion der Anzahl der Krankheitsepisoden (in der BT-Gruppe allerdings nur für die manischen Episoden) und der Anzahl und Dauer stationärer Krankenhausaufenthalte. Außerdem konnten in beiden Gruppen positive Auswirkungen auf Krankheitskonzepte und eine Reduktion psychosozialer Beeinträchtigungen gezeigt werden. <b><i>Schlussfolgerungen:</i></b> Beide Therapieformen sind wirksam in der Vorbeugung manischer Episoden, während nur die KPT-Gruppe auch einen Einfluss auf die Verhinderung depressiver Episoden sowie insgesamt eine höhere Wirksamkeit zeigte.
DOI: 10.6084/m9.figshare.5129911.v1
title: Supplementary Material for: Ressourcenaktivierung durch Perspektivwechsel. Stehen Sie doch einfach einmal auf! Ein Plädoyer für mehr Bewegung(en) in der Verhaltenstherapie

description: <b><i>Hintergrund:</i></b> Im Zustand emotionaler Aktivierung sind die Patienten in ihrem ich-syntonen Störungsattraktor fixiert. Mentale Perspektivwechsel haben eine zentrale Bedeutung für kognitive Neubewertungen. Durch körperliche Perspektivwechsel könnten vermutlich der Wechsel in andere Aktivierungszustände und die Aktivierung latent vorhandener Ressourcen im Sinne einer vertikalen Integration verschiedener Modalitäten umfassend unterstützt werden. <b><i>Methode:</i></b> Zehn teilweise aufeinander aufbauende Techniken mit verschiedenen Arten von Perspektivwechseln zum kontrollierten Balancieren zwischen emotionaler Aktivierung und Desidentifikation sowie Neubewertung werden dargestellt. Der Kontext ihrer Herkunft wird umrissen. <b><i>Ergebnis:</i></b> Diese komplexen Techniken ermöglichen in sehr dynamischer Weise die Aktivierung und Modifikation von Erlebens- und Verhaltensmustern, ohne die therapeutische Beziehung zu belasten. <b><i>Schlussfolgerung:</i></b> Diese Techniken der Beziehungsgestaltung und Prozesssteuerung könnten vermutlich unabhängig vom Störungsmodell bereits in der Therapieausbildung vermittelt werden.
DOI: 10.6084/m9.figshare.5129899
title: Supplementary Material for: Aufmerksamkeitsdefizit-/Hyperaktivitätsstörung über die Lebensspanne

description: Die Aufmerksamkeitsdefizit-/Hyperaktivitätsstörung (ADHS) ist eine Störung mit Beginn in der Kindheit und Jugend. Die Persistenzraten für das Erwachsenenalter liegen allerdings zwischen 20 bis über 80%. Demnach handelt es sich um eine chronische Störung, die über die Lebensspanne hinweg zu erheblichen Beeinträchtigungen führen kann. In diesem Übersichtsartikel werden zunächst die Symptomatik, Klassifikation, Komorbidität und Epidemiologie der Störung dargestellt, wobei auf Unterschiede in den verschiedenen Lebensphasen (Kindes-, Jugend- und Erwachsenenalter) eingegangen wird. Daran anschließend wird die ADHS als Entwicklungsstörung dargestellt und mögliche Entwicklungspfade und Risikofaktoren werden beschrieben. Abschließend werden diagnostische und therapeutische Ansätze in den unterschiedlichen Lebensphasen vorgestellt.
DOI: 10.6084/m9.figshare.5129905
title: Supplementary Material for: Risk Factors for Local Recurrence of Large, Flat Colorectal Polyps after Endoscopic Mucosal Resection

description: <b><i>Aims:</i></b> Removal of large, flat colorectal polyps by endoscopic mucosal resection (EMR) is effective, but local recurrences occur regularly. This study investigated risk factors for local recurrence. <b><i>Method:</i></b> Cases of EMR of flat colorectal polyps ≥20 mm at an academic center from 2004 to 2011 were retrospectively analyzed for polyp features, resection technique, complications and local recurrences. Behavioral risk factors were retrospectively determined by self-administered questionnaires. <b><i>Results:</i></b> Data were collected for 129 patients (57.3% male, mean age at time of EMR: 65.0 years). Mean polyp size was 37.2 mm. Polyps were mostly adenoma with low-grade dysplasia (58.1%) and predominantly located in the right colon (62%). En bloc resection was performed in 31.8%. The median follow-up time was 40 months. Local recurrence occurred in 26.3% of patients, with 87% being recurrence-free after 1 year (95% CI 81-93%). A history of smoking was reported by 51.6% of patients and 88.4% reported regular alcohol consumption. Univariate analysis showed that polyp size and piecemeal resection were associated with risk of local recurrence. In multivariate analysis, only polyp size was predictive for local recurrence. No association was found for behavioral risk factors. <b><i>Conclusion:</i></b> Polyp size is the main predictor of local recurrence after EMR of large, flat colorectal polyps.
DOI: 10.6084/m9.figshare.5129908.v1
title: Supplementary Material for: A 13-Year Retrospective Study on Primary Liver Cancer in Cambodia: A Strikingly High Hepatitis C Occurrence among Hepatocellular Carcinoma Cases

description: <b><i>Objectives:</i></b> Hepatocellular carcinoma (HCC) is the main type of primary liver cancer (PLC) worldwide, but cholangiocarcinoma (CCA) may be predominant in some specific regions of Southeast Asia. The aim of the present study was to delineate a pattern of Cambodian PLC patients attending the Calmette Hospital in the Cambodian capital Phnom Penh. <b><i>Materials and Methods:</i></b> A total of 553 medical charts diagnosing PLCs from January 2003 to May 2015 were obtained from both the Oncology and Hepato-Gastroenterology Departments of the Calmette Hospital. <b><i>Results:</i></b> HCC was the predominant type of PLC recorded, with 511 cases (92.4%), whereas CCA represented merely 7.6% (42 cases) of the overall series. Hepatitis B virus (HBV; 44.3%) and hepatitis C virus (HCV; 43%) infection rates were similar among the HCC patients, while small subsets of CCA patients were infected with HBV (15.4%) or HCV (11.5%). Most HCC (84%) and CCA (73.8%) patients received palliative treatment only. <b><i>Conclusion:</i></b> The present study indicates that HCC is the main form of primary hepatic neoplasm among PLC patients attending a hospital in Cambodia. HBV and HCV infections represented equivalent burdens and major contributing factors to HCC. Therefore, the implementation of prevention programs for these infectious agents should become a priority for health policy makers in the country.
DOI: 10.6084/m9.figshare.5129902
title: Supplementary Material for: Skin Care in the Tattoo Parlor: A Survey of Tattoo Artists in New York City

description: To understand the role that tattooists play in providing skin care advice, we conducted an online, survey-based study of 90 licensed tattooists in New York City. The survey asked tattooists about their exposure to adverse tattoo events, advising on tattoo removal/correction, behaviors regarding preexisting skin conditions and aftercare, confidence in addressing client questions about adverse events and preexisting conditions, and prior training about skin conditions related to tattoos. Most tattooists (92.8%) reported being asked by clients to evaluate adverse tattoo reactions, 85% were asked about tattoo removal, and 90% were asked about the safety of getting a tattoo with a preexisting skin condition. About half (56.1%) had received training about skin conditions related to tattoos. Tattooists with prior training reported higher rates of optimal skin care behaviors and higher confidence with tattoo-related skin conditions; 91.4% reported interest in skin care education. Tattooists play a major role in the skin health of their clients. Providing education for tattooists may improve skin care in populations less likely to see a dermatologist.
DOI: 10.6084/m9.figshare.5129917.v1
title: Supplementary Material for: Best Albuminuria Measurement to Predict Cardiovascular and Renal Events

description: <b><i>Background:</i></b> Kidney Disease Improving Global Outcomes (KDIGO) guidelines encourage clinicians to estimate 24-hour albuminuria as albumin to creatinine ratio (ACR) from spot urine samples. However, ACR underestimates 24-hour albumin excretion in muscular individuals. Equations that adjust ACR for surrogates of muscle mass to yield an estimated albumin excretion rate (eAER) were developed. We hypothesised that eAER is a better predictor of cardiovascular and renal outcomes than ACR. <b><i>Methods:</i></b> We determined ACR and eAER among 443 patients with chronic kidney disease G2-G4 recruited into the CARE FOR HOMe study. Patients were classified into KDIGO albuminuria categories, and followed for cardiovascular and renal events. The primary analysis was the net reclassification improvement (NRI) for those with and without events within 3 years of follow-up. <b><i>Results:</i></b> Eighty five patients experienced cardiovascular events during 3 years of follow-up, 13 of whom were reclassified to a more advanced albuminuria category, and 1 patient to a less advanced category by eAER compared to ACR (NRI<sub>event</sub>: 14.1% (95% CI 5.8-22.4)). Among 358 patients without a cardiovascular event, 17 patients were reclassified to a more advanced albuminuria category, and 2 patients to a less advanced category by eAER (NRI<sub>no event</sub>: -4.2%, 95% CI -8.5 to -1.8). Sixty patients went through renal events, and 383 patients had event-free 3-year follow-up. NRI<sub>event</sub> was 6.7% (95% CI -1.2 to 14.5), and NRI<sub>no event</sub> was -6.0% (95% CI -10.6 to 3.4) for renal events. <b><i>Conclusion:</i></b> Compared to ACR albuminuria categories, eAER categories are better associated with future cardiovascular events, but not with renal events.
DOI: 10.25442/hku.12857618
title: PhD Thesis dataset_Understanding the actions and transgenerational effects of Bisphenols on the reproductive functions in female mice

description: The dataset was constructed from the results of mouse experiments. The files with prefix ‘chapter 2’ were the data of embryo development, blastocyst attachment assay and implantation site number after blastocyst transfer. The files with prefix ‘chapter 3’ were the data record of mouse body weight, litter size, pregnancy outcomes, estrus cycle and steroid hormone level of female mice after chronical low-dose bisphenol exposure. This dataset also includes the results files of ovary follicle counting, IHC staining assay and TUNEL assay.
DOI: 10.6084/m9.figshare.5129893
title: Supplementary Material for: Older Adults' Use of Retrieval Strategies in Everyday Life

description: <b><i>Background:</i></b> Despite declines in cognitive abilities, older adults often perform comparable to younger adults in everyday tasks [J Am Geriatr Soc 1999;47:172-183]. Older adults may compensate for cognitive declines by using more efficient strategies. People often improve their efficiency by switching from an algorithmic strategy where information is computed or looked-up, to a strategy where the information is retrieved directly from memory [J Exp Psychol Gen 1988;117:258-275]. However, older adults are reluctant to shift from algorithmic strategies to retrieval strategies in the laboratory, and this reluctance to use retrieval is driven by both bottom-up (slower learning) and top-down influences (memory confidence, motivation to be quick/accurate) [Psychol Aging 2004;19:452-466; Mem Cognit 2004;32:298-310]. <b><i>Objective:</i></b> We investigated whether bottom-up and top-down factors influence younger and older adults' decisions to use retrieval-based or algorithmic strategies in everyday life. <b><i>Methods:</i></b> In two studies, participants completed a daily diary for 5 (study 1) or 7 (study 2) days. Participants were asked if and how they completed daily activities within several everyday task domains. They also indicated for how long and how often they completed the specific activity (bottom-up factors), as well as how confident they were in using their memory and how motivated they were to perform the specific activity quickly and accurately (top-down influences). <b><i>Results:</i></b> Both studies provided evidence for bottom-up and top-down influences. Additionally, study 2 found that top-down factors (memory confidence and motivation to be quick) were more important for older compared to younger adults. <b><i>Conclusion:</i></b> These results indicate that strategy choices influence older adults' cognitive efficiency in everyday as well as laboratory learning.
DOI: 10.6084/m9.figshare.5129896
title: Supplementary Material for: Fissure Integrity and Volume Reduction in Emphysema: A Retrospective Study

description: <b><i>Background:</i></b> One-way endobronchial valves (EBVs) relieve symptoms of emphysema, particularly in patients without collateral ventilation between the target and adjacent lobes. Pretreatment knowledge of fissure integrity could serve as an aid in indicating EBV interventions. <b><i>Objective:</i></b> This study aimed to investigate the relationship between software-measured lung fissure integrity and clinically relevant lung volume reduction (≥350 ml) in emphysema patients treated with one-way EBVs using a lobar exclusion strategy. <b><i>Methods:</i></b> Of 108 patients treated between March 2008 and July 2014, 38 had both baseline and follow-up computed tomography (CT) scans acquired following a specific protocol for quantitative CT analysis and were included in the study (total of 39 treatments, two lungs treated in 1 patient). Outcome measures were fissure integrity measured on baseline CT scans, difference between pre- and postoperative lung volume (considering the lowest measured postoperative volume), and correlation between fissure integrity and volume change. <b><i>Results:</i></b> Fissure integrity ≥75% correlated with volume reduction ≥350 ml (Spearman coefficient: -0.65; p &lt; 0.01). The mean and median volume reductions were 1,223.96 ± 907.5 ml and 663 ml, respectively, for lungs with fissure integrity ≥75% (n = 31). The accuracy of fissure integrity ≥75% in predicting a volume reduction was 87.2%. The positive predictive value of fissure integrity ≥75% to predict a volume reduction ≥350 ml was 83.9%, and it was 70% for fissure integrity 75-90% and 90.5% for fissure integrity &gt;90%. <b><i>Conclusions:</i></b> A target lobe volume reduction using EBVs is possible with lung fissure integrity ≥75%. For patients with fissure integrity between 75 and 90%, a further evaluation of interlobar ventilation should be performed. A clinically relevant volume reduction following treatment with EBVs is likely with any level of fissure integrity &gt;90%.