cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.15069936.v1
title: Supplementary 2.docx

description: The data represents the statistical values of different biochemical analysis measuring the oxidative stress in neuronal cells. Data demonstrated the significant changes in motor functions, dopamine level, cholinergic enzyme activity, adenosine deaminase, TNF-α and IL-1β level caused by rotenone induced Parkinson’s disease. Also, the combination of Mucuna pruriens extract and Sesame oil was observed to ameliorate oxidative stress and significantly increase the cholinergic enzyme activity and dopamine level and thereby helps in preventing neuronal cell damage.
DOI: 10.15129/cc4e5c7f-93c1-467c-b691-5d5b01082321
title: Data for: "Electrochemical biosensor development for enhanced detection of pathogens which cause sepsis and hyperinflammation"

description: This dataset is associated with the EPSRC Centre for doctoral training in medical devices and health technologies (Funder Project Reference: EP/L015595/1) thesis titled "Electrochemical biosensor development for enhanced detection of pathogens which cause sepsis and hyperinflammation", https://doi.org/10.15129/cc4e5c7f-93c1-467c-b691-5d5b01082321 thesis (20 May 2021). All experimental details are thoroughly described in the thesis. The data files consist of PSTrace software files (versions 5.0-5.8) for the potentiostat system Palmsens 4, Excell files (versions 2016 - office 365), Origin pro files (versions 2016 -2021) and PNG files.
DOI: 10.6084/m9.figshare.14247971
title: Kupffer Cell Loss Lipidomics Data

description: Lipidomics Data presented in ... et al.<br>Lipid levels are stored in the “LipidLevels” sheet as concentrations and relative abundances. Sample metadata in the “Metadata” sheet indicate dietary and treatment group for each sample as well as additional experimental information.
DOI: 10.6084/m9.figshare.14247971.v1
title: Kupffer Cell Loss Lipidomics Data

description: Lipidomics Data presented in ... et al.<br>Lipid levels are stored in the “LipidLevels” sheet as concentrations and relative abundances. Sample metadata in the “Metadata” sheet indicate dietary and treatment group for each sample as well as additional experimental information.
DOI: 10.17028/rd.lboro.15141165
title: Supplementary Information files for A chiral lanthanide tag for stable and rigid attachment to single cysteine residues in proteins for NMR, EPR and time-resolved luminescence studies

description: Supplementary Information files for A chiral lanthanide tag for stable and rigid attachment to single cysteine residues in proteins for NMR, EPR and time-resolved luminescence studies<br>A lanthanide-binding tag site-specifically attached to a protein presents a tool to probe the protein by multiple spectroscopic techniques, including nuclear magnetic resonance, electron paramagnetic resonance and time-resolved luminescence spectroscopy. Here a new stable chiral LnIII tag, referred to as C12, is presented for spontaneous and quantitative reaction with a cysteine residue to generate a stable thioether bond. The synthetic protocol of the tag is relatively straightforward, and the tag is stable for storage and shipping. It displays greatly enhanced reactivity towards selenocysteine, opening a route towards selective tagging of selenocysteine in proteins containing cysteine residues. Loaded with TbIII or TmIII ions, the C12 tag readily generates pseudocontact shifts (PCS) in protein NMR spectra. It produces a relatively rigid tether between lanthanide and protein, which is beneficial for interpretation of the PCSs by single magnetic susceptibility anisotropy tensors, and it is suitable for measuring distance distributions in double electron–electron resonance experiments. Upon reaction with cysteine or other thiol compounds, the TbIII complex exhibits a 100-fold enhancement in luminescence quantum yield, affording a highly sensitive turn-on luminescence probe for time-resolved FRET assays and enzyme reaction monitoring.
DOI: 10.17028/rd.lboro.15141165.v1
title: Supplementary Information files for A chiral lanthanide tag for stable and rigid attachment to single cysteine residues in proteins for NMR, EPR and time-resolved luminescence studies

description: Supplementary Information files for A chiral lanthanide tag for stable and rigid attachment to single cysteine residues in proteins for NMR, EPR and time-resolved luminescence studies<br>A lanthanide-binding tag site-specifically attached to a protein presents a tool to probe the protein by multiple spectroscopic techniques, including nuclear magnetic resonance, electron paramagnetic resonance and time-resolved luminescence spectroscopy. Here a new stable chiral LnIII tag, referred to as C12, is presented for spontaneous and quantitative reaction with a cysteine residue to generate a stable thioether bond. The synthetic protocol of the tag is relatively straightforward, and the tag is stable for storage and shipping. It displays greatly enhanced reactivity towards selenocysteine, opening a route towards selective tagging of selenocysteine in proteins containing cysteine residues. Loaded with TbIII or TmIII ions, the C12 tag readily generates pseudocontact shifts (PCS) in protein NMR spectra. It produces a relatively rigid tether between lanthanide and protein, which is beneficial for interpretation of the PCSs by single magnetic susceptibility anisotropy tensors, and it is suitable for measuring distance distributions in double electron–electron resonance experiments. Upon reaction with cysteine or other thiol compounds, the TbIII complex exhibits a 100-fold enhancement in luminescence quantum yield, affording a highly sensitive turn-on luminescence probe for time-resolved FRET assays and enzyme reaction monitoring.
DOI: 10.6084/m9.figshare.15141189
title: French Survey - PUBLIC AWARENESS, KNOWLEDGE OF AVAILABILITY, AND READINESS FOR NEUROSURGICAL CARE SERVICES_ AN E-SURVEY FOR XX AFRICAN COUNTRIES (Responses).xlsx

description: Data for the Project <b>Public Awareness, Knowledge of Availability, and Willingness to Use Neurosurgical Care Services in Sub-Saharan Africa: A Cross-Sectional Study</b>
DOI: 10.6084/m9.figshare.15141189.v1
title: French Survey - PUBLIC AWARENESS, KNOWLEDGE OF AVAILABILITY, AND READINESS FOR NEUROSURGICAL CARE SERVICES_ AN E-SURVEY FOR XX AFRICAN COUNTRIES (Responses).xlsx

description: Data for the Project <b>Public Awareness, Knowledge of Availability, and Willingness to Use Neurosurgical Care Services in Sub-Saharan Africa: A Cross-Sectional Study</b>
DOI: 10.6084/m9.figshare.15141147
title: Supplementary Material for: Levothyroxine Administration during Ramadan: A Prospective Randomized Controlled Trial

description: <b><i>Background and Aim:</i></b> We have previously shown in a retrospective analysis that the plasma thyroid-stimulating hormone (TSH) rises significantly post-Ramadan in levothyroxine-treated hypothyroid patients, possibly as a result of lifestyle alterations and time restrictions during the nonfasting period from dusk until dawn. The aim of this study is to determine the best time to instruct patients to take levothyroxine during Ramadan so as to minimize changes in thyroid function tests during this period. <b><i>Methods:</i></b> In a randomized prospective design, hypothyroid patients taking levothyroxine were randomized to receive instructions to take levothyroxine at one of the following 3 times during Ramadan: (group 1) at dusk 30-min before Iftar meal, (group 2) 3 or more hours after Iftar meal, or (group 3) at dawn 30-min before Suhur meal. Thyroid function tests were performed within 3 months before Ramadan and within 6 weeks post-Ramadan. Data from patients with at least 1 blood test before or after Ramadan were analyzed using mixed-effects regression models. <b><i>Results:</i></b> Plasma TSH levels were available at one or more time points for 148 patients, group 1 (<i>n</i> = 50), group 2 (<i>n</i> = 46), and group 3 (<i>n</i> = 52). A statistically significant within-patient increase in plasma TSH was seen in patients at the 25th percentile pre-Ramadan in groups 2 and 3 (<i>p</i> values &lt;0.001), but not in group 1. A statistically significant within-patient decrease in plasma TSH was found in patients at the 75th percentile in group 1 only. For patients at the 50th percentile pre-Ramadan, no statically significant within-patient changes were found, though descriptively, increases in plasma TSH were observed for groups 2 and 3, while a decrease was observed in group 1. <b><i>Conclusions:</i></b> Our data suggest that instructing patients to take levothyroxine at the time of breaking the fast 30 min before the Iftar meal minimizes unfavorable changes in plasma TSH post-Ramadan. In contrast, instructing patients to take levothyroxine 3 h post-Iftar or 30 min before Suhur led to a greater rise in post-Ramadan TSH.
DOI: 10.6084/m9.figshare.15141147.v1
title: Supplementary Material for: Levothyroxine Administration during Ramadan: A Prospective Randomized Controlled Trial

description: <b><i>Background and Aim:</i></b> We have previously shown in a retrospective analysis that the plasma thyroid-stimulating hormone (TSH) rises significantly post-Ramadan in levothyroxine-treated hypothyroid patients, possibly as a result of lifestyle alterations and time restrictions during the nonfasting period from dusk until dawn. The aim of this study is to determine the best time to instruct patients to take levothyroxine during Ramadan so as to minimize changes in thyroid function tests during this period. <b><i>Methods:</i></b> In a randomized prospective design, hypothyroid patients taking levothyroxine were randomized to receive instructions to take levothyroxine at one of the following 3 times during Ramadan: (group 1) at dusk 30-min before Iftar meal, (group 2) 3 or more hours after Iftar meal, or (group 3) at dawn 30-min before Suhur meal. Thyroid function tests were performed within 3 months before Ramadan and within 6 weeks post-Ramadan. Data from patients with at least 1 blood test before or after Ramadan were analyzed using mixed-effects regression models. <b><i>Results:</i></b> Plasma TSH levels were available at one or more time points for 148 patients, group 1 (<i>n</i> = 50), group 2 (<i>n</i> = 46), and group 3 (<i>n</i> = 52). A statistically significant within-patient increase in plasma TSH was seen in patients at the 25th percentile pre-Ramadan in groups 2 and 3 (<i>p</i> values &lt;0.001), but not in group 1. A statistically significant within-patient decrease in plasma TSH was found in patients at the 75th percentile in group 1 only. For patients at the 50th percentile pre-Ramadan, no statically significant within-patient changes were found, though descriptively, increases in plasma TSH were observed for groups 2 and 3, while a decrease was observed in group 1. <b><i>Conclusions:</i></b> Our data suggest that instructing patients to take levothyroxine at the time of breaking the fast 30 min before the Iftar meal minimizes unfavorable changes in plasma TSH post-Ramadan. In contrast, instructing patients to take levothyroxine 3 h post-Iftar or 30 min before Suhur led to a greater rise in post-Ramadan TSH.
DOI: 10.5281/zenodo.5175256
title: Replication package for: Geography and Agricultural Productivity: Cross-Country Evidence from Micro Plot-Level Data

description: The package contains all the data and code necessary to reproduce the results in Adamopoulos and Restuccia (forthcoming). "Geography and Agricultural Productivity: Cross-Country Evidence from Micro Plot-Level Data." <em>Review of Economic Studies</em>. Detailed instructions on how to use the files are provided in a README file.
DOI: 10.5517/ccdc.csd.cc27sxdc
title: CCDC 2079523: Experimental Crystal Structure Determination

description: Related Article: Anthony J. Smith, Jeanette A. Krause|2021|CSD Communication|||
DOI: 10.5517/ccdc.csd.cc28g7ss
title: CCDC 2099065: Experimental Crystal Structure Determination

description: Related Article: Brian W. Skelton, Effendy, Allan H. White|2021|CSD Communication|||
DOI: 10.5517/ccdc.csd.cc28gnq4
title: CCDC 2099466: Experimental Crystal Structure Determination

description: Related Article: Arnold L. Rheingold|2021|CSD Communication|||
DOI: 10.5517/ccdc.csd.cc28gyh6
title: CCDC 2099738: Experimental Crystal Structure Determination

description: Related Article: Arnold L. Rheingold, Linda H. Doerrer and Alice Fan|2021|CSD Communication|||
DOI: 10.5517/ccdc.csd.cc28hmdt
title: CCDC 2100386: Experimental Crystal Structure Determination

description: Related Article: W. Clegg, K. Guille|2021|CSD Communication|||
DOI: 10.5517/ccdc.csd.cc28hmfv
title: CCDC 2100387: Experimental Crystal Structure Determination

description: Related Article: W. Clegg, K. Guille|2021|CSD Communication|||
DOI: 10.5517/ccdc.csd.cc28hmgw
title: CCDC 2100388: Experimental Crystal Structure Determination

description: Related Article: W. Clegg, K. Guille|2021|CSD Communication|||
DOI: 10.5517/ccdc.csd.cc28hmhx
title: CCDC 2100389: Experimental Crystal Structure Determination

description: Related Article: W. Clegg, K. Guille|2021|CSD Communication|||
DOI: 10.5517/ccdc.csd.cc28hqj1
title: CCDC 2100483: Experimental Crystal Structure Determination

description: Related Article: Peter G. Jones, Eliza Târcoveanu, Henning Hopf|2021|CSD Communication|||
DOI: 10.5517/ccdc.csd.cc28hqk2
title: CCDC 2100484: Experimental Crystal Structure Determination

description: Related Article: Peter G. Jones, Eliza Târcoveanu, Henning Hopf|2021|CSD Communication|||
DOI: 10.5517/ccdc.csd.cc28hql3
title: CCDC 2100485: Experimental Crystal Structure Determination

description: Related Article: Peter G. Jones, Eliza Târcoveanu, Henning Hopf|2021|CSD Communication|||
DOI: 10.5517/ccdc.csd.cc28hqm4
title: CCDC 2100486: Experimental Crystal Structure Determination

description: Related Article: Peter G. Jones, Eliza Târcoveanu, Henning Hopf|2021|CSD Communication|||
DOI: 10.5517/ccdc.csd.cc28hqn5
title: CCDC 2100487: Experimental Crystal Structure Determination

description: Related Article: Peter G. Jones, Eliza Târcoveanu, Henning Hopf|2021|CSD Communication|||
DOI: 10.5517/ccdc.csd.cc28hqp6
title: CCDC 2100488: Experimental Crystal Structure Determination

description: Related Article: Peter G. Jones, Eliza Târcoveanu, Henning Hopf|2021|CSD Communication|||
DOI: 10.5517/ccdc.csd.cc28hsm6
title: CCDC 2100548: Experimental Crystal Structure Determination

description: Related Article: Arnold L. Rheingold|2021|CSD Communication|||
DOI: 10.5517/ccdc.csd.cc28hsrb
title: CCDC 2100552: Experimental Crystal Structure Determination

description: Related Article: Arnold L. Rheingold and Phil S. Baran|2021|CSD Communication|||
DOI: 10.5517/ccdc.csd.cc28ht8w
title: CCDC 2100568: Experimental Crystal Structure Determination

description: Related Article: Arnold L. Rheingold and Phil S. Baran|2021|CSD Communication|||
DOI: 10.5517/ccdc.csd.cc28htcz
title: CCDC 2100571: Experimental Crystal Structure Determination

description: Related Article: Arnold L. Rheingold and Phil S. Baran|2021|CSD Communication|||
DOI: 10.5517/ccdc.csd.cc28htqb
title: CCDC 2100582: Experimental Crystal Structure Determination

description: Related Article: W. Clegg, K. Guille|2021|CSD Communication|||
DOI: 10.5517/ccdc.csd.cc28htrc
title: CCDC 2100583: Experimental Crystal Structure Determination

description: Related Article: W. Clegg, K. Guille|2021|CSD Communication|||
DOI: 10.5517/ccdc.csd.cc28htsd
title: CCDC 2100584: Experimental Crystal Structure Determination

description: Related Article: W. Clegg, K. Guille|2021|CSD Communication|||
DOI: 10.5517/ccdc.csd.cc28hz81
title: CCDC 2100723: Experimental Crystal Structure Determination

description: Related Article: Brian W. Skelton, Effendy, Allan H. White|2021|CSD Communication|||
DOI: 10.5517/ccdc.csd.cc28j241
title: CCDC 2100812: Experimental Crystal Structure Determination

description: Related Article: Brian W. Skelton, Effendy, Allan H. White|2021|CSD Communication|||
DOI: 10.5517/ccdc.csd.cc28j7jl
title: CCDC 2100979: Experimental Crystal Structure Determination

description: Related Article: Arnold L. Rheingold and Phil S. Baran|2021|CSD Communication|||
DOI: 10.5517/ccdc.csd.cc28j7km
title: CCDC 2100980: Experimental Crystal Structure Determination

description: Related Article: Arnold L. Rheingold and Phil S. Baran|2021|CSD Communication|||
DOI: 10.5517/ccdc.csd.cc28jc17
title: CCDC 2101088: Experimental Crystal Structure Determination

description: Related Article: Brian W. Skelton, Effendy, Allan H. White|2021|CSD Communication|||
DOI: 10.5517/ccdc.csd.cc28jnk1
title: CCDC 2101383: Experimental Crystal Structure Determination

description: Related Article: Brian W. Skelton, Effendy, Allan H. White|2021|CSD Communication|||
DOI: 10.5517/ccdc.csd.cc28jtd1
title: CCDC 2101533: Experimental Crystal Structure Determination

description: Related Article: Arnold L. Rheingold and Phil S. Baran|2021|CSD Communication|||
DOI: 10.5517/ccdc.csd.cc28jtf2
title: CCDC 2101534: Experimental Crystal Structure Determination

description: Related Article: Arnold L. Rheingold and Phil S. Baran|2021|CSD Communication|||
DOI: 10.5281/zenodo.5173011
title: DEVoC

description: Danish Enteric Virome Catalog (DEVoC) with genes, annotations & normalized counts in Danish cohort.
DOI: 10.34740/kaggle/dsv/2514401
title: Dutch News Articles
DOI: 10.5281/zenodo.5174952
title: Riboswitch-inspired toehold riboregulators for gene regulation in Escherichia coli

description: This dataset comprises flow cytometry data accompanying a publication on the development of synthetic riboregulators. These riboregulators were inspired by the architecture of naturally occurring riboswitches and toehold-mediated strand displacement. Specifically, we adopt the toehold switch hairpin and inserted regulatory sequences within the loop region of which accessibility can be controlled by toehold-mediated strand displacement. We utilized this design principle to develop toehold translation repressor and toehold transcriptional repressor, which regulate mCherry expression in <em>E. coli </em>in translational and transcriptional levels with certain ON/OFF ratios. Furthermore, we combined these two riboregulators and developed them into a NOR gate switch that can regulate downstream GFP expression in <em>E. coli </em>with different input conditions of trigger RNA. We used flow cytometry to quantify the expression level of the NOR gate switch under different inputs.
description: Flow cytometry of riboregulator logic gates was performed using a BD FACSMelodyTM cell sorter. Flow cytometry data were analyzed using FlowJo 10.1r1 software (FLOWJO).
DOI: 10.5281/zenodo.5174951
title: Riboswitch-inspired toehold riboregulators for gene regulation in Escherichia coli

description: This dataset comprises flow cytometry data accompanying a publication on the development of synthetic riboregulators. These riboregulators were inspired by the architecture of naturally occurring riboswitches and toehold-mediated strand displacement. Specifically, we adopt the toehold switch hairpin and inserted regulatory sequences within the loop region of which accessibility can be controlled by toehold-mediated strand displacement. We utilized this design principle to develop toehold translation repressor and toehold transcriptional repressor, which regulate mCherry expression in <em>E. coli </em>in translational and transcriptional levels with certain ON/OFF ratios. Furthermore, we combined these two riboregulators and developed them into a NOR gate switch that can regulate downstream GFP expression in <em>E. coli </em>with different input conditions of trigger RNA. We used flow cytometry to quantify the expression level of the NOR gate switch under different inputs.
description: Flow cytometry of riboregulator logic gates was performed using a BD FACSMelodyTM cell sorter. Flow cytometry data were analyzed using FlowJo 10.1r1 software (FLOWJO).
DOI: 10.6084/m9.figshare.13194095
title: European Primary Forest Database

description: The European Primary Forest Database is a curated collection of (sub)-national and regional datasets on the distribution of primary forests in Europe. It contains geographical (GIS) data (point, polygons) on the location and boundaries of documented primary and old-growth forests in Europe<br>
DOI: 10.6084/m9.figshare.12493106.v2
title: Campylobacter jejuni genotypes associated with post-infection irritable bowel syndrome

description: <i>Campylobacter</i> enterocolitis can lead to post-infection irritable bowel syndrome (PI-IBS) but the factors promoting its emergence are poorly understood. While some <i>C. jejuni</i> strains are more significant for human disease, genomic and virulence characteristics that promote PI-IBS development are unknown. We combined pangenome-wide association studies and laboratory microbiology to compare <i>C. jejuni </i>from patients that develop PI-IBS with those that do not. Variation in bacterial stress response (<i>Cj0145_phoX</i>), adhesion protein (<i>Cj0628_CapA</i>), and core biosynthetic pathway genes (biotin: <i>Cj0308_bioD</i>; purine: <i>Cj0514_purQ</i>; isoprenoid: <i>Cj0894c_ispH</i>) associated with PI-IBS development. <i>In vitro </i>assays demonstrated enhanced adhesion, invasion, epithelial barrier disruption, and IL-8 secretion with PI-IBS strains. Twenty-two genomic markers, four of which in an uncharacterized gene <i>Cj1631c, </i>were used to develop a risk-score for PI-IBS development. Demonstrating that specific <i>Campylobacter</i> genotypes confer greater <i>in vitro</i> virulence and increased risk of PI-IBS has potential to improve understanding of the complex host-pathogen interactions underlying this condition.
DOI: 10.5281/zenodo.5155653
title: A large crystallographic dataset (3600 degrees) from insulin using an Eiger 2 XE 9M on I04-1 at Diamond Light Source Ltd

description: 3600 degree X-ray diffraction data set from cubic insulin taken on Diamond Beamline i04-1 with the Eiger 2 XE 9M detector at 500 Hz, for use by method developers to improve and streamline the analysis of large crystallographic datasets.
DOI: 10.5281/zenodo.5155652
title: A large crystallographic dataset (3600 degrees) from insulin using an Eiger 2 XE 9M on I04-1 at Diamond Light Source Ltd

description: 3600 degree X-ray diffraction data set from cubic insulin taken on Diamond Beamline i04-1 with the Eiger 2 XE 9M detector at 500 Hz, for use by method developers to improve and streamline the analysis of large crystallographic datasets.
DOI: 10.5281/zenodo.5175546
title: GENES supplementary data

description: The origin of plasma-derived bacterial extracellular vesicles in healthy individuals and patients with inflammatory bowel disease: A pilot study Supplementary Data: Table S1: Taxa (ASV level) abundance in protocol control and plasma samples. Table S2: Differential genera in protocol control and plasma samples identified by classical univariate analysis (CUA). Table S3: Taxa (ASV level) abundance in healthy control (HC), Crohn’s disease (CD) and ulcerative colitis (UC) plasma samples. Table S4: Differential genera in healthy control (HC), Crohn’s disease (CD) and ulcerative colitis (UC) plasma samples identified by classical univariate analysis (CUA).
DOI: 10.5281/zenodo.5175545
title: GENES supplementary data

description: The origin of plasma-derived bacterial extracellular vesicles in healthy individuals and patients with inflammatory bowel disease: A pilot study Supplementary Data: Table S1: Taxa (ASV level) abundance in protocol control and plasma samples. Table S2: Differential genera in protocol control and plasma samples identified by classical univariate analysis (CUA). Table S3: Taxa (ASV level) abundance in healthy control (HC), Crohn’s disease (CD) and ulcerative colitis (UC) plasma samples. Table S4: Differential genera in healthy control (HC), Crohn’s disease (CD) and ulcerative colitis (UC) plasma samples identified by classical univariate analysis (CUA).