cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.5281/zenodo.7599603
title: XJ_COTTON10: The 10-m cotton field maps in Xinjiang, China during 2018-2021

description: The datasets will accompany the paper "The 10-m cotton field maps in Xinjiang, China during 2018–2021". The datasets contain the 10-m cotton field maps of Xinjiang (XJ_COTTON10) from 2018 to 2021. They were developed through supervised classification using high-quality in-field samples and multi-source remote sensing data on the Google Earth Engine (GEE) platform.
DOI: 10.5281/zenodo.7266100
title: XJ_COTTON10: The 10-m cotton maps in Xinjiang, China during 2018-2021

description: The datasets accompany the paper "The 10-m cotton maps in Xinjiang, China during 2018–2021" that was published in Scientific Data on Oct. 10, 2023. The datasets contain the 10-m cotton maps of Xinjiang (XJ_COTTON10) from 2018 to 2021. They were developed through supervised classification using high-quality in-field samples and multi-source remote sensing data on the Google Earth Engine (GEE) platform.
Citation:
[1] Kang, X., Huang, C., Chen, J.M., Lv, X., Wang, J., Zhong, T., Wang, H., Fan, X., Ma, Y., Yi, X., Zhang, Z., Zhang, L., Tong, Q., 2023. The 10-m cotton maps in Xinjiang, China during 2018-2021. Sci Data 10, 688. doi:10.1038/s41597-023-02584-3
[2] Lang, P., Zhang, L., Huang, C., Chen, J., Kang, X., Zhang, Z., Tong, Q., 2023. Integrating environmental and satellite data to estimate county-level cotton yield in Xinjiang Province. Frontiers in Plant Science 13, 1048479. doi:10.3389/fpls.2022.1048479
[3] Kang, X., Huang, C., Zhang, L., Zhang, Z., Lv, X., 2022. Downscaling solar-induced chlorophyll fluorescence for field-scale cotton yield estimation by a two-step convolutional neural network. Computers and Electronics in Agriculture 201, 107260. doi:10.1016/j.compag.2022.107260
[4] Kang, X., Huang, C., Zhang, L., Wang, H., Zhang, Z., Lv, X., 2023. Regional-scale cotton yield forecast via data-driven spatio-temporal prediction (STP) of solar-induced chlorophyll fluorescence (SIF). Remote Sensing of Environment 299, 113861. doi:10.1016/j.rse.2023.113861
DOI: 10.5281/zenodo.7856467
title: XJ_COTTON10: The 10-m cotton maps in Xinjiang, China during 2018-2021

description: The datasets will accompany the paper "The 10-m cotton maps in Xinjiang, China during 2018–2021". The datasets contain the 10-m cotton maps of Xinjiang (XJ_COTTON10) from 2018 to 2021. They were developed through supervised classification using high-quality in-field samples and multi-source remote sensing data on the Google Earth Engine (GEE) platform.
DOI: 10.18167/dvn1/jsahfb
title: SARRA-H Modèle de culture : Système d'Analyse Régionale des Risques Agroclimatologiques Version H

description: SARRA-H est une évolution forte de la suite du logiciel SARRA qui est un bilan hydrique dynamique simple utilisé pour estimer l’impact d’un scénario climatique sur une culture annuelle. SARRA-H est spécifiquement adapté à l'analyse d'impact du climat sur la croissance des céréales sèches (mil, sorgho, mais, riz) et du rendement potentiel en milieu tropical ; les derniers développements permettent aussi de simuler le soja et le coton. Les mots clefs qui sont à la base des choix de développement du modèle sont : simplicité, robustesse et performances. Le modèle de culture simule le rendement potentiel sous contraintes hydriques en intégrant les processus de bilan hydrique des sols, d'évaporation et de transpiration potentielle et réelle, de phénologie, d'assimilation potentielle et sous contraintes hydriques, de respiration de maintenance et enfin de répartition des biomasses (feuilles, tiges, racines, grains). SARRA-H gère une librairie de formalismes (modules) qui intègrent le principe classique du frein hydrique (bilan hydrique) et le combine avec une croissance potentielle, fonction du rayonnement et de son interception par le couvert (bilan carbone). Il s’agit d’un modèle multiplicatif (ressource hydrique x ressource radiative), complété par un module phénologique (phénologie) pour structurer le cycle de végétation et les processus liés à chaque stade phénologique, par une description simple mais dynamique du couvert (« big leaf », caractérisé par des coefficients morphologiques et géométriques), et par une élaboration physiologique du rendement (compétition source-puits).
DOI: 10.6084/m9.figshare.24298504
title: Supplementary Material for: C-terminal PEGylation improves SAAP-148 peptide's immunomodulatory activities

description: Synthetic antibacterial and anti-biofilm peptide (SAAP)-148 was developed to combat bacterial infections not effectively treatable with current antibiotics. SAAP-148 is highly effective against antimicrobial-resistant (AMR) bacteria without inducing resistance, however challenges for further development of SAAP-148 include its cytotoxicity and short circulation half-life. To circumvent these drawbacks a library of SAAP-148 linked to polyethylene glycol (PEG) groups of various lengths was screened for in vitro antibacterial activity and hemolytic activity. Results indicated that PEGylated SAAP-148 variants combine antibacterial activities with reduced hemolysis compared to SAAP-148. Interestingly, pro-inflammatory immunomodulatory activities of SAAP-148 were enhanced upon C-terminal PEGylation, with SAAP-148-PEG27 showing most effect. SAAP-148-PEG27 enhanced SAAP-148’s capacity to chemoattract human neutrophils and was able to more efficiently (re)direct M-CSF-induced monocyte-macrophage differentiation towards type 1 macrophages compared to SAAP-148. Furthermore, dendritic cells with a stronger mature expression profile were produced if monocytes were exposed to SAAP-148-PEG27 during monocyte-immature dendritic cell differentiation in comparison to SAAP-148. Parameters that influenced the immunomodulatory activities of the peptide-PEG conjugate include i) the length of the PEG-group, ii) the position of PEG conjugation, and iii) the peptide sequence. Together, these results indicate that SAAP-148-PEG27 is highly effective in redirecting monocyte-macrophage differentiation towards a proinflammatory phenotype and promoting monocyte-mature dendritic cells development. Therefore, SAAP-148-PEG27 may be a promising agent to modulate inadequate immune responses in case of tumors and chronically infected wounds.
DOI: 10.6084/m9.figshare.24298504.v1
title: Supplementary Material for: C-terminal PEGylation improves SAAP-148 peptide's immunomodulatory activities

description: Synthetic antibacterial and anti-biofilm peptide (SAAP)-148 was developed to combat bacterial infections not effectively treatable with current antibiotics. SAAP-148 is highly effective against antimicrobial-resistant (AMR) bacteria without inducing resistance, however challenges for further development of SAAP-148 include its cytotoxicity and short circulation half-life. To circumvent these drawbacks a library of SAAP-148 linked to polyethylene glycol (PEG) groups of various lengths was screened for in vitro antibacterial activity and hemolytic activity. Results indicated that PEGylated SAAP-148 variants combine antibacterial activities with reduced hemolysis compared to SAAP-148. Interestingly, pro-inflammatory immunomodulatory activities of SAAP-148 were enhanced upon C-terminal PEGylation, with SAAP-148-PEG27 showing most effect. SAAP-148-PEG27 enhanced SAAP-148’s capacity to chemoattract human neutrophils and was able to more efficiently (re)direct M-CSF-induced monocyte-macrophage differentiation towards type 1 macrophages compared to SAAP-148. Furthermore, dendritic cells with a stronger mature expression profile were produced if monocytes were exposed to SAAP-148-PEG27 during monocyte-immature dendritic cell differentiation in comparison to SAAP-148. Parameters that influenced the immunomodulatory activities of the peptide-PEG conjugate include i) the length of the PEG-group, ii) the position of PEG conjugation, and iii) the peptide sequence. Together, these results indicate that SAAP-148-PEG27 is highly effective in redirecting monocyte-macrophage differentiation towards a proinflammatory phenotype and promoting monocyte-mature dendritic cells development. Therefore, SAAP-148-PEG27 may be a promising agent to modulate inadequate immune responses in case of tumors and chronically infected wounds.
DOI: 10.6084/m9.figshare.24173838
title: Supplementary Material for: ‘A Global, Regional, and National Survey on Burden and Quality of Care Index (QCI) of Multiple Sclerosis; Global Burden of Disease Systematic Analysis 1990-2019’

description: Background: Multiple sclerosis (MS) is a common neurologic autoimmune disorder. We have used a newly introduced measure, Quality of Care Index (QCI), which is associated with the efficacy of care given to patients suffering from MS. Objective: To report and compare the quality of care given to MS patients in different regions and country. Method: Primary measures were retrieved from Global Burden of Disease (GBD) from 1990 to 2019. Secondary measures (mortality to incidence ratio, DALY to prevalence ratio, prevalence to incidence ratio, and YLL to YLD ratio) were combined using Principle Component Analysis (PCA), to form an essential component (QCI) (0-100 index with higher values representing better condition). Findings: In 2019, there were 59,345 (95% UI 51,818 to 66,943) new MS incident case globally. Global QCI of 88.4 was calculated for 2019. At national level, Qatar had the highest quality of care (100) followed by Kuwait (98.5) and Greenland (98.1). The lowest QCI was observed in Kiribati (13.5), Nauru (31.5), and Seychelles (36.3), respectively. Most countries have reached gender equity during the 30 years. Also, QCI was lowest in ages from 55 to 80 in global scale. Conclusion: MS QCI is better among those countries of higher socioeconomic status, possibly due to better healthcare access and early detection in these regions. Countries could benefit from adopting the introduced QCI to evaluate the quality of care given to MS patients in national and global level.
DOI: 10.6084/m9.figshare.24173838.v1
title: Supplementary Material for: ‘A Global, Regional, and National Survey on Burden and Quality of Care Index (QCI) of Multiple Sclerosis; Global Burden of Disease Systematic Analysis 1990-2019’

description: Background: Multiple sclerosis (MS) is a common neurologic autoimmune disorder. We have used a newly introduced measure, Quality of Care Index (QCI), which is associated with the efficacy of care given to patients suffering from MS. Objective: To report and compare the quality of care given to MS patients in different regions and country. Method: Primary measures were retrieved from Global Burden of Disease (GBD) from 1990 to 2019. Secondary measures (mortality to incidence ratio, DALY to prevalence ratio, prevalence to incidence ratio, and YLL to YLD ratio) were combined using Principle Component Analysis (PCA), to form an essential component (QCI) (0-100 index with higher values representing better condition). Findings: In 2019, there were 59,345 (95% UI 51,818 to 66,943) new MS incident case globally. Global QCI of 88.4 was calculated for 2019. At national level, Qatar had the highest quality of care (100) followed by Kuwait (98.5) and Greenland (98.1). The lowest QCI was observed in Kiribati (13.5), Nauru (31.5), and Seychelles (36.3), respectively. Most countries have reached gender equity during the 30 years. Also, QCI was lowest in ages from 55 to 80 in global scale. Conclusion: MS QCI is better among those countries of higher socioeconomic status, possibly due to better healthcare access and early detection in these regions. Countries could benefit from adopting the introduced QCI to evaluate the quality of care given to MS patients in national and global level.
DOI: 10.21430/m32kgrdm51
title: JAX CCHI-Modulation of Lung Responses to Viral Infection- ALI SARS-CoV2

description: Spatiotemporally organized immunomodulatory response to SARS-CoV-2 virus in primary human broncho-alveolar epithelia. Use of lung donors from NDRI to make organoids, then lung organoid-derived air-liquid interface (ALI) cultures with infection of SARS-CoV2 like virus or mock. To better understand the early spatiotemporal events happening in lung epithelium during SARS-CoV-2 infection and their potential biological consequences, we based our study on an in vitro model of primary human airway epithelial cells: air-liquid interface (ALI) cultures generated from human lung organoids from healthy donors. Such cultures effectively recapitulate in vivo airway epithelium architecture and we validated their permissibility to viral infection by exposure to SARS-CoV-2 (Wuhan-like, USA/WA1-2020) and its variants (Beta, Delta and Omicron BA.1 subvariant). Our findings reveal spatiotemporal regulation of cytokines, chemokines and suggest that different cells in the lung epithelium may regulate different aspects of immune response to SARS-CoV-2. Furthermore, the use of lung organoid-derived ALI from a variety of donors revealed differential infection dynamics reflecting biological differences between individuals, potentially explaining some of the diverse clinical outcomes observed between patients.
DOI: 10.21430/m3tw6siail
title: Toll-like Receptors in Older Adults and Response to Vaccination - Year2

description: We will identify how age and frailty affect gene expression signatures of vaccine response.
DOI: 10.21430/m3265dvd4i
title: 35th Multicenter Airway Research Collaboration (MARC-35): EWAS analysis of infants

description: In a multicenter prospective cohort study of infants hospitalized with bronchiolitis, we profiled their epigenome-wide blood DNA methylation level at hospitalization using Infinium MethylationEPIC BeadChip. We found that blood DNA methylation signatures were associated with bronchiolitis severity and various respiratory and immune traits.
DOI: 10.21430/m3z6jx4cz3
title: Nplate® PK/PD Study with or without Neulasta® in Rhesus Macaque

description: Study to characterize the pharmacokinetic (PK) and pharmacodynamic (PD) profile of the test item, romiplostim (Nplate®), following one or two subcutaneous administrations to irradiated (target LD30/45) rhesus macaque non-human primates (NHP), with or without subcutaneous administration of pegfilgrastim (Neulasta®).
DOI: 10.21430/m3tog3ll8h
title: Interactions between Siglec-8 and endogenous sialylated cis ligands restrain cell death induction in human eosinophils and mast cells

description: Sialic acid-binding immunoglobulin-like lectin (Siglec)-8 is a sialoside-binding receptor expressed on the surface of eosinophils and mast cells that bears an immunoreceptor tyrosine-based inhibitory motif (ITIM) and an ITIM-like motif in its cytoplasmic domain. On eosinophils that have been primed with IL-5, GM-CSF, or IL-33, antibody ligation of Siglec-8 leads to cell death through a pathway involving the β2 integrin-dependent generation of reactive oxygen species (ROS) via NADPH oxidase. In contrast, engagement of Siglec-8 on mast cells has been described to inhibit mast cell activation and mediator release but not impact cell viability. The differences in responses between cytokine-primed and unprimed eosinophils, and between eosinophils and mast cells, to Siglec-8 ligation are not understood. In addition, we have previously found that Siglec-8 binds to sialylated ligands on the surface of the same cell (so-called cis ligands) on eosinophils, preventing interaction with a Siglec-8 ligand in trans. However, the functional relevance of these cis ligands have not been elucidated. We therefore explored the potential influence of cis ligands of Siglec-8 on the surfaces of both eosinophils and mast cells. Removal of sialic acid using exogenous sialidase had profound effects on the consequences of Siglec-8 antibody engagement on both cell types, eliminating the need for cytokine priming of eosinophils to facilitate cell death and enabling Siglec-8-dependent mast cell death without impacting anti-Siglec-8 antibody binding. The cell death process licensed by incubation with sialidase resembled that characterized in IL-5-primed eosinophils, including the upregulation of CD11b, production of ROS, and requirement for the signaling activities of Syk, PI3K, and PLC. These results implicate cis ligands in restraining Siglec-8 function on eosinophils and mast cells and reveal a promising approach to the selective depletion of mast cells in patients with mast cell-mediated diseases.
DOI: 10.21430/m3ixipwf5g
title: Immune repertoire sequencing of Coeliac patients

description: Immune repertoire sequencing of 12 CeD patients and 8 non-CeD controls.
DOI: 10.21430/m3jdi4t17w
title: Mucosal antibody responses to SARS-CoV-2 booster vaccination and breakthrough infection

description: Here, the investigators measured serum IgG, saliva IgG and saliva secretory IgA responses in individuals who experienced breakthrough infections and who received COVID-19 mRNA booster vaccinations.
DOI: 10.21430/m32pg4uujv
title: Preconception Genetic Carrier Screening for Miscarriage Risk Assessment: A Bioinformatic Approach to Identifying Candidate Lethal Genes and Variants

description: This study explored the influence of known and potential genes on prenatal lethality and preconception genetic carrier screening (PGCS) across diverse populations. Using bioinformatics, researchers identified essential genes for fetal survival, examined variants absent in homozygous states in healthy populations, and estimated heterozygous carrier rates for lethal conditions. A total of 3080 lethal genes were identified, with a high frequency of lethal variants in 163 genes within the general population. These findings highlight the need for a comprehensive, pan-ethnic PGCS panel, incorporating genes associated with miscarriage to enhance prenatal care and prevention efforts across various ethnic groups.
DOI: 10.21430/m315vhmrps
title: Effects of Inhibiting Early Inflammation in Kidney Transplant Patients (CTOT-19)

description: This is a Phase II, Multicenter, randomized, double blind, placebo-controlled, 2-arm clinical trial of 300 deceased donor kidney transplant recipients. Subjects will be randomized 1:1 to the experimental or control arms (150 subjects per arm).
DOI: 10.21430/m31x313hws
title: Decay of coronavirus disease 2019 mRNA vaccine-induced immunity in people with HIV

description: To analyze humoral and cellular immunity 6 months post COVID-19 mRNA vaccination in people with HIV and healthy donors.
DOI: 10.21430/m3w35wn8an
title: Nucleocapsid-specific antibody function is associated with therapeutic benefits from COVID-19 convalescent plasma therapy

description: To evaluate the association between clinical benefits of convalescent plasma (CCP) and inflammatory Spike (S) responses and nucleocapsid (N) humoral responses.
DOI: 10.21430/m3x6em3tv0
title: mRNA-1273 and BNT162b2 mRNA vaccines have reduced neutralizing activity against the SARS-CoV-2 omicron variant

description: To evaluate the neutralizing activity of mRNA-1273 and BNT162b2 mRNA vaccines against omicron variant in individuals after initial two-vaccine doses and third dose.
DOI: 10.21430/m36xn11o1y
title: Durability of immune responses to the BNT162b2 mRNA vaccine

description: To measure antibody responses to several SARS-CoV-2 variants of interest in BNT162b2 (Pfizer) mRNA vaccinated individuals at 6 months after the second dose.
DOI: 10.21430/m322sv4pv1
title: Rapid decline in vaccine-boosted neutralizing antibodies against SARS-CoV-2 Omicron variant

description: To assess the magnitude and short-term durability of neutralizing antibodies after homologous and heterologous boosting with mRNA and Ad26.COV2.S vaccines against SARS-CoV-2 Omicron variant.
DOI: 10.21430/m3t7a0kv72
title: Maternal SARS-CoV-2 infection elicits sexually dimorphic placental immune responses

description: To assess maternal-fetal antibody transfer, viral-induced placental IFN responses, and the impact of fetal sex in pregnant humans infected with SARS-CoV-2.
DOI: 10.21430/m346bqs8lq
title: Infant rhesus macaques immunized against SARS-CoV-2 are protected against heterologous virus challenge 1 year later

description: To provide proof of concept that immune responses induced by early-life vaccination would persist and protect from severe disease after high-dose challenge with a heterologous variant 1 year after vaccination.
DOI: 10.21430/m3mx4r10p8
title: Discovery and intranasal administration of a SARS-CoV-2 broadly acting neutralizing antibody with activity against multiple Omicron subvariants

description: To discover and characterize therapeutic antibodies with the breadth and potency of neutralizing activity required to treat newly diagnosed COVID-19 linked to recently emerged variants of concern including Omicron subvariants BA.1, BA.1.1, and BA.2.
DOI: 10.21430/m3yezofrtu
title: Antigen-adjuvant interactions, stability, and immunogenicity profiles of a SARS-CoV-2 receptor-binding domain (RBD) antigen formulated with aluminum salt and CpG adjuvants

description: To elucidate the key interrelationships between antigen-adjuvant interactions, storage stability, and in vivo performance to enable successful formulation development of stable and efficacious subunit vaccines.
DOI: 10.21430/m3ygg0hfge
title: SARS-CoV-2 infection produces chronic pulmonary epithelial and immune cell dysfunction with fibrosis in mice

description: To identify pathways associated with persistent SARS-CoV-2 pulmonary disease and test countermeasures to ameliorate post-acute sequelae of SARS-CoV-2
DOI: 10.5281/zenodo.10025071
title: MITgcm model setup and output for "Submesoscale variability and basal melting in ice shelf cavities of the Amundsen Sea"

description: Here, it contains the results of the high-res eastern AMS simulation. A detailed description of the model configuration and model output is provided by Nakayama et al.,2019.
Nakayama, Yoshihiro, Georgy Manucharyan, Hong Zhang, Pierre Dutrieux, Hector S. Torres, Patrice Klein, Helene Seroussi, Michael Schodlok, Eric Rignot, and Dimitris Menemenlis. "Pathways of ocean heat towards Pine Island and Thwaites grounding lines." Scientific reports 9, no. 1 (2019): 16649.
Due to space limitations, please access NASA data for all other model daily outputs (Registration is required).  https://ecco.jpl.nasa.gov/drive/files/ECCO2/High_res_PIG/AMS_200m. 
Contents can be downloaded easily using wget (see link below).https://ecco-group.org/docs/wget_download_multiple_files_and_directories.pdf
(Contents)code.zip (code to run this simulation)input_ctrl.zip (input file required for this simulation input_nomelt.zip (input file required for this simulation results_ctrl.zip (days 30 and 60))results_nomelt.zip (days 30 and 60))Caution: You need to download heavier input files to rerun this simulation from ECCO-Drive. (How to build and run)mkdir build./../../tools/genmake2 -of ../../../tools/build_options/linux_amd64_ifort+mpi_ice_nas -mpi -mods ../code/make dependmake -j 16cd ..mkdir testcd testln -sf ../input/* .ln -sf /nobackup/hzhang1/forcing/era_xx_it33/ .cp ../build/mitgcm_uv .qsub run8_sandy_tracer_init_cont_2.pbs
DOI: 10.5281/zenodo.10026724
title: The Effects of Differential Tropospheric Error on the Measurement of Wide-swath Interferometric Altimetry

description: Related dataset and codes for the paper "The Effects of Differential Tropospheric Error on the Measurement of Wide-swath Interferometric Altimetry" submitted to IEEE TGRS.
DOI: 10.5281/zenodo.10026590
title: The Effects of Differential Tropospheric Error on the Measurement of Wide-swath Interferometric Altimetry

description: Related dataset and codes for the paper "The Effects of Differential Tropospheric Error on the Measurement of Wide-swath Interferometric Altimetry" submitted to IEEE TGRS.
DOI: 10.5281/zenodo.10026591
title: The Effects of Differential Tropospheric Error on the Measurement of Wide-swath Interferometric Altimetry

description: Related dataset and codes for the paper "The Effects of Differential Tropospheric Error on the Measurement of Wide-swath Interferometric Altimetry" submitted to IEEE TGRS.