cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.11997624
title: The Effect of Electropulsing Treatment on Properties of Pre-compressed AZ31 Magnesium Alloy

description: The effect of electropulsing treatment (EPT) on quasi-static compression behavior and anisotropy of AZ31 Mg alloy were investigated based on quasi-static compression test. The results show that the orientation of the sample has a significant effect on the deformation mechanism of metal and this mechanism can be changed by pre-deformation and EPT. However, the strain rate sensitivity of the material is not affected by pre-deformation. Compared with the as-received plates, the anisotropy of AZ31 Mg alloy increased in ND-RD plane after pre-compression along the transverse direction, the ∆YS of specimens increased from 87 MPa to 98 MPa. After EPT, the anisotropy of AZ31 Mg alloy gradually decreased with the change of EPT temperature and EPT time, the ∆YS of the sample reached 14.2 MPa when EPT conducted at 200 ℃ for 15 min, which decreased 72.8 MPa compared with the as-received plates.
DOI: 10.6084/m9.figshare.11997627.v1
title: CFD simulation and PIV validation of the gas/liquid behavior in an UASB reactor

description: ABSTRACT As the world population increases, the need to develop more efficient wastewater treatment systems requires the use of new technologies. Software aided project and optimization of bioreactors and bioprocesses have become a matter of interest in recent years, especially due to the advance in the state-of-the-art of computational resources. This work aimed to perform gas/liquid numerical simulations using the Fluent 16.2 software and to validate this model through Particle Image Velocimetry (PIV) and shadow imaging techniques. Eulerian-Eulerian, laminar, tridimensional and transient simulations were carried out. The results for the mass imbalance for the gas and liquid phases, gas volumetric fraction, gas velocity, bubble size, liquid magnitude and upflow velocity and the velocity profiles for the liquid phase were successfully validated against experimental data. Concerning the dispersed phase, it was found a difference of 4.37% for the gas volumetric fraction between experiments and simulations. Simulated results showed a difference for the bubble mean velocity of 1.73% when compared with shadow imaging results. No coalescence was observed along the experiments, and the flow regime was characterized as dispersed bubble flow. Regarding the liquid phase, it was found a difference of 3.2% for the mean velocity, between simulated and PIV results. Simulated and experimental velocity profiles showed a better agreement at the center of the reactor. Some differences were observed in those profiles, due to geometry simplifications assumed in order to get a better mesh. Considering the good agreement between simulation and experiments, the model was considered validated.
DOI: 10.6084/m9.figshare.11997624.v1
title: The Effect of Electropulsing Treatment on Properties of Pre-compressed AZ31 Magnesium Alloy

description: The effect of electropulsing treatment (EPT) on quasi-static compression behavior and anisotropy of AZ31 Mg alloy were investigated based on quasi-static compression test. The results show that the orientation of the sample has a significant effect on the deformation mechanism of metal and this mechanism can be changed by pre-deformation and EPT. However, the strain rate sensitivity of the material is not affected by pre-deformation. Compared with the as-received plates, the anisotropy of AZ31 Mg alloy increased in ND-RD plane after pre-compression along the transverse direction, the ∆YS of specimens increased from 87 MPa to 98 MPa. After EPT, the anisotropy of AZ31 Mg alloy gradually decreased with the change of EPT temperature and EPT time, the ∆YS of the sample reached 14.2 MPa when EPT conducted at 200 ℃ for 15 min, which decreased 72.8 MPa compared with the as-received plates.
DOI: 10.6084/m9.figshare.11997612
title: Neuroprotective and MAOB inhibitory effects of a series of caffeine-8-thioglycolic acid amides

description: The effects of new derivatives of caffeine-8-thioglycolic acid (100 µM) on isolated rat brain synaptosomes, human neuroblastoma cell line SH-SY5Y and human recombinant MAOB enzyme (hMAOB) (1 µM) were evaluated. Most of the compounds, administered alone, didn’t show statistically significant neurotoxic effects on SH-SY5Y, when compared to the control (non-treated cells). Of all studied structures JTA-2Ox, JTA-11, JTA-12 and JTA-13 decreased cell viability. In combination with 6-hydroxydopamine (6-OHDA) (100 µM), only JTA-1 and JTA-2 revealed neuroprotective effects, stronger than those of caffeine. All compounds administered alone revealed, neurotoxic effects on synaptosomes, as compared to non-treated synaptosomes. JTA-1, JTA-2 and JTA-3 showed lowest neurotoxic effects and were investigated in a model of 6-OHDA-induced oxidative stress. In this model of neurotoxicity, only JTA-1 and JTA-2 showed statistically significant neuroprotective effect, by preserving the synaptosomal viability and the level of reduced glutathione. Inhibition of hMAOB, was revealed by JTA-1 and JTA-2. They inhibited the enzyme by 23% and 25% respectively, thus approaching the selegiline activity, which was 42%. The possible mechanisms of neuroprotection of JTA-1 and JTA-2 might be a result from the inhibition of hMAOB, which catalyze the production of neurotoxic p-quinone from 6-OHDA.
DOI: 10.6084/m9.figshare.11997615
title: CLASSIFICATION OF LOW BACK PAIN INTO SUBGROUPS FOR DIAGNOSTIC AND THERAPEUTIC CLARITY

description: ABSTRACT Objective To establish a classification in subgroups with symptoms and functionality involving volunteers with nonspecific chronic low back pain for better clarity of functional and therapeutic diagnostic definitions. Methods Observational, quantitative, cross-sectional study with population of 62 university students between 18 and 30 years of age, with a mean age of 21.40 (± 2.40) years, presenting nonspecific lumbar pain for more than three months. Three questionnaires were used for the division into subgroups: STarT Back Screening, the Oswestry Disability Index, and FABQ-Brasil, the VAS evaluation, orthopedic tests: Lasègue’s, Slump test, de Sèze test, Valsalva maneuver, and evaluation of the pain threshold of the right and left iliocostal lumbar muscles. Results All the volunteers included in the study had chronic back pain. Most of them (50%) had normal body mass index, 54.8% were sedentary, and of those who were physically active, 14.5% did body building. The Slump test (35.5%) proved to be more reliable than Lasègue’s test (21%). In the evaluation, the volunteers reported moderate pain intensity (72.6%) and the mean pressure pain threshold was 6.37 kgf and 6.14 kgf for the right and left iliocostal muscles, respectively. In the questionnaires, 85.5% had a low-risk score, that is, a good prognosis for pain treatment, and 91.9% had minimum disability. The largest treatment hypothesis group was stabilization (29.0%). Conclusion The method of treatment subgroup classification is a guide towards better semiological perspectives and the definition of the clinically preferred physiotherapeutic treatment for each case. Level of Evidence III; Diagnostic study.
DOI: 10.6084/m9.figshare.11997612.v1
title: Neuroprotective and MAOB inhibitory effects of a series of caffeine-8-thioglycolic acid amides

description: The effects of new derivatives of caffeine-8-thioglycolic acid (100 µM) on isolated rat brain synaptosomes, human neuroblastoma cell line SH-SY5Y and human recombinant MAOB enzyme (hMAOB) (1 µM) were evaluated. Most of the compounds, administered alone, didn’t show statistically significant neurotoxic effects on SH-SY5Y, when compared to the control (non-treated cells). Of all studied structures JTA-2Ox, JTA-11, JTA-12 and JTA-13 decreased cell viability. In combination with 6-hydroxydopamine (6-OHDA) (100 µM), only JTA-1 and JTA-2 revealed neuroprotective effects, stronger than those of caffeine. All compounds administered alone revealed, neurotoxic effects on synaptosomes, as compared to non-treated synaptosomes. JTA-1, JTA-2 and JTA-3 showed lowest neurotoxic effects and were investigated in a model of 6-OHDA-induced oxidative stress. In this model of neurotoxicity, only JTA-1 and JTA-2 showed statistically significant neuroprotective effect, by preserving the synaptosomal viability and the level of reduced glutathione. Inhibition of hMAOB, was revealed by JTA-1 and JTA-2. They inhibited the enzyme by 23% and 25% respectively, thus approaching the selegiline activity, which was 42%. The possible mechanisms of neuroprotection of JTA-1 and JTA-2 might be a result from the inhibition of hMAOB, which catalyze the production of neurotoxic p-quinone from 6-OHDA.
DOI: 10.6084/m9.figshare.11997615.v1
title: CLASSIFICATION OF LOW BACK PAIN INTO SUBGROUPS FOR DIAGNOSTIC AND THERAPEUTIC CLARITY

description: ABSTRACT Objective To establish a classification in subgroups with symptoms and functionality involving volunteers with nonspecific chronic low back pain for better clarity of functional and therapeutic diagnostic definitions. Methods Observational, quantitative, cross-sectional study with population of 62 university students between 18 and 30 years of age, with a mean age of 21.40 (± 2.40) years, presenting nonspecific lumbar pain for more than three months. Three questionnaires were used for the division into subgroups: STarT Back Screening, the Oswestry Disability Index, and FABQ-Brasil, the VAS evaluation, orthopedic tests: Lasègue’s, Slump test, de Sèze test, Valsalva maneuver, and evaluation of the pain threshold of the right and left iliocostal lumbar muscles. Results All the volunteers included in the study had chronic back pain. Most of them (50%) had normal body mass index, 54.8% were sedentary, and of those who were physically active, 14.5% did body building. The Slump test (35.5%) proved to be more reliable than Lasègue’s test (21%). In the evaluation, the volunteers reported moderate pain intensity (72.6%) and the mean pressure pain threshold was 6.37 kgf and 6.14 kgf for the right and left iliocostal muscles, respectively. In the questionnaires, 85.5% had a low-risk score, that is, a good prognosis for pain treatment, and 91.9% had minimum disability. The largest treatment hypothesis group was stabilization (29.0%). Conclusion The method of treatment subgroup classification is a guide towards better semiological perspectives and the definition of the clinically preferred physiotherapeutic treatment for each case. Level of Evidence III; Diagnostic study.
DOI: 10.6084/m9.figshare.11997603
title: Return period and spatialization of maximum precipitations by the Moments method for the state of Bahia

description: ABSTRACT The hydrological study of precipitations allows estimating, among other characteristics, the time of recurrence of a certain rainfall, from historical bases and probabilistic calculations, which is especially important when it comes to extreme events. Thus, the objective of the present work was to estimate the probable maximum daily precipitation for the return periods of 2, 5, 10, 20, 50 and 100 years according to the Gumbel distribution, using the moments method, and to analyze the spatialization of these events for the entire state of Bahia, Brazil. The study used the historical series of the 28 rainfall stations of INMET from 1961 to 2015, applying the Gumbel method through the parameters obtained from the equations of the moments, being the data tested by the Kolmogorov-Smirnov method. For the spatialization of the results, ArcGIS 10.3 was used by means of Inverse Distance Weighting (IDW) interpolation for each return time. The coastal and central portion of the state is more predisposed to the occurrence of extreme events. The moments methods allowed to estimate the parameters used in the Gumbel equation, making it possible to spatialize and analyze the maximum precipitations for the studied state.
DOI: 10.6084/m9.figshare.11997603.v1
title: Return period and spatialization of maximum precipitations by the Moments method for the state of Bahia

description: ABSTRACT The hydrological study of precipitations allows estimating, among other characteristics, the time of recurrence of a certain rainfall, from historical bases and probabilistic calculations, which is especially important when it comes to extreme events. Thus, the objective of the present work was to estimate the probable maximum daily precipitation for the return periods of 2, 5, 10, 20, 50 and 100 years according to the Gumbel distribution, using the moments method, and to analyze the spatialization of these events for the entire state of Bahia, Brazil. The study used the historical series of the 28 rainfall stations of INMET from 1961 to 2015, applying the Gumbel method through the parameters obtained from the equations of the moments, being the data tested by the Kolmogorov-Smirnov method. For the spatialization of the results, ArcGIS 10.3 was used by means of Inverse Distance Weighting (IDW) interpolation for each return time. The coastal and central portion of the state is more predisposed to the occurrence of extreme events. The moments methods allowed to estimate the parameters used in the Gumbel equation, making it possible to spatialize and analyze the maximum precipitations for the studied state.
DOI: 10.6084/m9.figshare.11997597
title: Nephroprotective activity of the enriched polyphenol extract of Euterpe edulis Martius

description: Contrast-induced nephropathy (NIC) is directly related to increased morbidity and mortality, and its treatment and prevention might be achieved by the administration of antioxidant products. The juçara palmetto (Euterpe edulis Martius) has fruits rich in phenolic compounds, which are known for their antioxidant activity. This work aimed to evaluate the nephroprotective activity of E. edulis pulp in the NIC animal model. The collected fruits were pulped, their contents of polyphenols and anthocyanins were quantified, and their antioxidant activity were evaluated. The nephroprotective effects were determined based on iodine contrast induction and evaluated by biochemical and histological analyses. The results showed that E. edulis pulp was rich in polyphenols (811 ± 16.7 mg EAG/g) and anthocyanins (181.25 mg/100 g) and had very strong antioxidant activity, as demonstrated by the DPPH (2,2-diphenyl-1-picryl-hydrazyl) method, which revealed an antioxidant activity index (AAI) of 3.4, and the 2,29-azinobis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) method, which revealed an IC50 of 0.59 ± 0.03 mg/mL. In the in vivo experiments, E. edulis pulp tended to provide renal protection and reduce renal dysfunction and tubular morphological lesions in mice after the induction of NIC, and these effects were obtained through the antioxidant activities of the polyphenols in the pulp.
DOI: 10.6084/m9.figshare.11997597.v1
title: Nephroprotective activity of the enriched polyphenol extract of Euterpe edulis Martius

description: Contrast-induced nephropathy (NIC) is directly related to increased morbidity and mortality, and its treatment and prevention might be achieved by the administration of antioxidant products. The juçara palmetto (Euterpe edulis Martius) has fruits rich in phenolic compounds, which are known for their antioxidant activity. This work aimed to evaluate the nephroprotective activity of E. edulis pulp in the NIC animal model. The collected fruits were pulped, their contents of polyphenols and anthocyanins were quantified, and their antioxidant activity were evaluated. The nephroprotective effects were determined based on iodine contrast induction and evaluated by biochemical and histological analyses. The results showed that E. edulis pulp was rich in polyphenols (811 ± 16.7 mg EAG/g) and anthocyanins (181.25 mg/100 g) and had very strong antioxidant activity, as demonstrated by the DPPH (2,2-diphenyl-1-picryl-hydrazyl) method, which revealed an antioxidant activity index (AAI) of 3.4, and the 2,29-azinobis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) method, which revealed an IC50 of 0.59 ± 0.03 mg/mL. In the in vivo experiments, E. edulis pulp tended to provide renal protection and reduce renal dysfunction and tubular morphological lesions in mice after the induction of NIC, and these effects were obtained through the antioxidant activities of the polyphenols in the pulp.
DOI: 10.6084/m9.figshare.11997582
title: Gd-GLU toward NMR imaging: synthesis, characterization and breast cell uptake assay

description: Breast cancer cell uptake of Gd-metal is investigated based on the formation of coordinate compounds of gadolinium and glucose (Glu) molecules in solution. The hypothesis is that glucose helps Gd-internalization by complex formations constituted of Gd3+ coordinate to m-glucose molecules, whose valence was complemented by Cl- anions. Such a proposal is an insight toward a metabolic-dependent contrast-agent for cancer and inflammation in magnetic resonance image. A solution was prepared based on anhydrous d-glucose and gadolinium chloride (Gd-Glu). Uptake assays for MDA-MB-231(c231) cells were elaborated collecting incubated c231-cells with Gd-Glu and measuring metal-uptake and their concentrations by Nuclear Activation Analysis (NAA). The ionic solution was studied using Direct-Infusion Electrospray Ionization Mass-Spectrometry (ESI-MS) to identify Gd-Glu interactions. Means and standard deviations of Gd-masses were 13.3±0.8 and 12.5±0.7µg, at 361.5 µg of Gd in 3mL Gd-Glu/PBS solution, in times of 30-50 min, equivalent to the concentrations of 13404±2104 and 11347±2742 µg.g-1 in dried cells. Such values were statistically higher than the control with metal presence. ESI-MS demonstrated the m/z-signals at 516, 552, 696, 923, attributed to positively loaded-species containing Glu, Gd+3 and Cl-. In conclusion, Gd-internalization was increased in aqueous solution due to the gadolinium-glucose coordination. Such findings drive the research to MRI with Gd-Glu complexes.
DOI: 10.6084/m9.figshare.11997579
title: Microwave-assisted synthesis and pharmacological screening of some triazolothiadiazole derivatives

description: In this study, twenty-two new [1,2,4]triazolo[3,4-b][1,3,4]thiadiazoles (5a-n, 6a-h) were synthesized under microwave irradiation (MWI). The chemical structures of the compounds were elucidated by their IR, 1H-NMR, LC-MS, and elemental analysis. The compounds were tested for antinociceptive activity by using the tail clip, tail flick, hot plate, and writhing methods in mice. The varying levels of antinociceptive activity of the compounds were compared with those of aspirin. Among these compounds, compound 5g and 5j were found to be significantly more active than the other compounds and the standard in the tests. Also, inhibitory effects of the test compounds on COX-1 and COX-2 activities were investigated. DuP-697 for COX-2 and SC-560 for COX-1 were used as reference standards.
DOI: 10.6084/m9.figshare.11997582.v1
title: Gd-GLU toward NMR imaging: synthesis, characterization and breast cell uptake assay

description: Breast cancer cell uptake of Gd-metal is investigated based on the formation of coordinate compounds of gadolinium and glucose (Glu) molecules in solution. The hypothesis is that glucose helps Gd-internalization by complex formations constituted of Gd3+ coordinate to m-glucose molecules, whose valence was complemented by Cl- anions. Such a proposal is an insight toward a metabolic-dependent contrast-agent for cancer and inflammation in magnetic resonance image. A solution was prepared based on anhydrous d-glucose and gadolinium chloride (Gd-Glu). Uptake assays for MDA-MB-231(c231) cells were elaborated collecting incubated c231-cells with Gd-Glu and measuring metal-uptake and their concentrations by Nuclear Activation Analysis (NAA). The ionic solution was studied using Direct-Infusion Electrospray Ionization Mass-Spectrometry (ESI-MS) to identify Gd-Glu interactions. Means and standard deviations of Gd-masses were 13.3±0.8 and 12.5±0.7µg, at 361.5 µg of Gd in 3mL Gd-Glu/PBS solution, in times of 30-50 min, equivalent to the concentrations of 13404±2104 and 11347±2742 µg.g-1 in dried cells. Such values were statistically higher than the control with metal presence. ESI-MS demonstrated the m/z-signals at 516, 552, 696, 923, attributed to positively loaded-species containing Glu, Gd+3 and Cl-. In conclusion, Gd-internalization was increased in aqueous solution due to the gadolinium-glucose coordination. Such findings drive the research to MRI with Gd-Glu complexes.
DOI: 10.6084/m9.figshare.11997579.v1
title: Microwave-assisted synthesis and pharmacological screening of some triazolothiadiazole derivatives

description: In this study, twenty-two new [1,2,4]triazolo[3,4-b][1,3,4]thiadiazoles (5a-n, 6a-h) were synthesized under microwave irradiation (MWI). The chemical structures of the compounds were elucidated by their IR, 1H-NMR, LC-MS, and elemental analysis. The compounds were tested for antinociceptive activity by using the tail clip, tail flick, hot plate, and writhing methods in mice. The varying levels of antinociceptive activity of the compounds were compared with those of aspirin. Among these compounds, compound 5g and 5j were found to be significantly more active than the other compounds and the standard in the tests. Also, inhibitory effects of the test compounds on COX-1 and COX-2 activities were investigated. DuP-697 for COX-2 and SC-560 for COX-1 were used as reference standards.
DOI: 10.6084/m9.figshare.11997573
title: Wave energy distribution at inlet channel margins as a function of ebb tidal delta morphology: Cananéia Inlet, São Paulo, Brazil

description: Abstract Wave energy gradients between and along the margins of inlet channels play an important role in defining the inlet margins’ evolutionary processes, mainly those related to spit erosion or accretion, and inlet migration. The aim of this study is to understand the wave power distribution along the margins of a tidal inlet (Cananéia inlet, São Paulo, Brazil), its variation over time, and the influences of the ebb tidal delta morphology on the incoming waves. To evaluate changes in bathymetry and morphology of submersed features, we apply geoprocessing techniques to analyze nautical charts from the Brazilian Navy from 1939, 1971, 1985 and 2004. The numerical model MIKE21 SW was applied to assess wave propagation and nearshore wave power. Hence, wave energy levels along the inlet margins were assessed in terms of decadal morphological changes. The results indicate a dynamic behavior of the inlet and ebb tidal delta, pointing to the ebb tidal delta as the main transforming agent of the waves that reach the inner portion of the channel. The morphological changes of the ebb tidal delta over the last decades are critical to define the action of waves on the margins of the inlet.