cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.29820127
title: The impact of antithrombin III supplementation on prognosis during extracorporeal membrane oxygenation: a systematic review and meta-analysis

description: To systematically evaluate the impact of antithrombin III (AT III) supplementation on the prognosis of patients undergoing extracorporeal membrane oxygenation (ECMO). A comprehensive literature search was conducted in PubMed, Web of Science, Embase, and the Cochrane Library for studies assessing the effects of AT III supplementation on ECMO patient outcomes. The risk of bias was assessed using the Cochrane Risk of Bias and The Newcastle-Ottawa Scale. A total of six studies involving 18,641 ECMO-treated patients were included. The meta-analysis showed that AT III supplementation did not reduce mortality in ECMO patients (RR = 1.17, 95% CI: 0.85–1.60, <i>p</i> = 0.34) and had no significant benefit in reducing bleeding events (RR = 1.04, 95% CI: 0.90–1.21, <i>p</i> = 0.56) or thrombosis (RR = 1.29, 95% CI: 0.81–2.05, <i>p</i> = 0.29). Subgroup analysis revealed that in cardiac ECMO patients, AT III supplementation was associated with an increased mortality but a reduced risk of thromboembolism. Conversely, in other ECMO support types, AT III supplementation was linked to a higher incidence of thromboembolism, with adult patients also showing an increased thromboembolism rate. No statistically significant differences were observed in other subgroup analyses. Overall, AT III supplementation does not reduce in-hospital mortality, bleeding, or thrombotic complications in ECMO patients and may even pose risks in certain populations. Therefore, routine AT III supplementation in ECMO patients may be not currently recommended.
DOI: 10.6084/m9.figshare.29820127.v1
title: The impact of antithrombin III supplementation on prognosis during extracorporeal membrane oxygenation: a systematic review and meta-analysis

description: To systematically evaluate the impact of antithrombin III (AT III) supplementation on the prognosis of patients undergoing extracorporeal membrane oxygenation (ECMO). A comprehensive literature search was conducted in PubMed, Web of Science, Embase, and the Cochrane Library for studies assessing the effects of AT III supplementation on ECMO patient outcomes. The risk of bias was assessed using the Cochrane Risk of Bias and The Newcastle-Ottawa Scale. A total of six studies involving 18,641 ECMO-treated patients were included. The meta-analysis showed that AT III supplementation did not reduce mortality in ECMO patients (RR = 1.17, 95% CI: 0.85–1.60, <i>p</i> = 0.34) and had no significant benefit in reducing bleeding events (RR = 1.04, 95% CI: 0.90–1.21, <i>p</i> = 0.56) or thrombosis (RR = 1.29, 95% CI: 0.81–2.05, <i>p</i> = 0.29). Subgroup analysis revealed that in cardiac ECMO patients, AT III supplementation was associated with an increased mortality but a reduced risk of thromboembolism. Conversely, in other ECMO support types, AT III supplementation was linked to a higher incidence of thromboembolism, with adult patients also showing an increased thromboembolism rate. No statistically significant differences were observed in other subgroup analyses. Overall, AT III supplementation does not reduce in-hospital mortality, bleeding, or thrombotic complications in ECMO patients and may even pose risks in certain populations. Therefore, routine AT III supplementation in ECMO patients may be not currently recommended.
DOI: 10.6084/m9.figshare.29767288
title: Integrating systemic inflammation and liver biomarkers: prognostic implications of the ferritin index in heart failure

description: Heart failure (HF) is increasingly recognized as a multisystem syndrome involving systemic inflammation and metabolic dysfunction in addition to cardiac and hepatic impairment. Traditional liver fibrosis scores, such as the fibrosis-4 (FIB-4) index, focus solely on hepatic injury and may underestimate the broader systemic burden. The ferritin index, which adjusts serum ferritin for age and sex, may better reflect inflammatory and metabolic dysregulation, including features of metabolic hyperferritinaemia. This study aimed to evaluate the prognostic value of the ferritin index versus the FIB-4 score in predicting major adverse cardiovascular events (MACE) in patients with HF. This retrospective cohort study included 751 HF patients from the Changhua Christian Hospital Clinical Research Database, spanning all ejection fraction categories. Cox regression models were used to assess associations between MACE and tertiles of ferritin index and FIB-4 score, with adjustments for baseline characteristics. Patients in the highest ferritin index tertile had significantly increased MACE risk (adjusted hazard ratio 1.92; <i>p</i> = 0.003). This association remained robust in the sensitivity and subgroup analyses. The FIB-4 score was not significantly associated with MACE. Subgroup analysis showed stronger associations in patients aged ≥70 years, with higher BMI (≥24 kg/m<sup>2</sup>), reduced EF, low FIB-4 (&lt;1.45), and abnormal hemoglobin or iron levels. The ferritin index outperforms the FIB-4 score in predicting MACE in HF patients. By integrating systemic inflammatory and metabolic signals, it improves risk stratification, especially in those with features of metabolic hyperferritinaemia.
DOI: 10.6084/m9.figshare.29767288.v1
title: Integrating systemic inflammation and liver biomarkers: prognostic implications of the ferritin index in heart failure

description: Heart failure (HF) is increasingly recognized as a multisystem syndrome involving systemic inflammation and metabolic dysfunction in addition to cardiac and hepatic impairment. Traditional liver fibrosis scores, such as the fibrosis-4 (FIB-4) index, focus solely on hepatic injury and may underestimate the broader systemic burden. The ferritin index, which adjusts serum ferritin for age and sex, may better reflect inflammatory and metabolic dysregulation, including features of metabolic hyperferritinaemia. This study aimed to evaluate the prognostic value of the ferritin index versus the FIB-4 score in predicting major adverse cardiovascular events (MACE) in patients with HF. This retrospective cohort study included 751 HF patients from the Changhua Christian Hospital Clinical Research Database, spanning all ejection fraction categories. Cox regression models were used to assess associations between MACE and tertiles of ferritin index and FIB-4 score, with adjustments for baseline characteristics. Patients in the highest ferritin index tertile had significantly increased MACE risk (adjusted hazard ratio 1.92; <i>p</i> = 0.003). This association remained robust in the sensitivity and subgroup analyses. The FIB-4 score was not significantly associated with MACE. Subgroup analysis showed stronger associations in patients aged ≥70 years, with higher BMI (≥24 kg/m<sup>2</sup>), reduced EF, low FIB-4 (&lt;1.45), and abnormal hemoglobin or iron levels. The ferritin index outperforms the FIB-4 score in predicting MACE in HF patients. By integrating systemic inflammatory and metabolic signals, it improves risk stratification, especially in those with features of metabolic hyperferritinaemia.
DOI: 10.6084/m9.figshare.30928055
title: Sex- and ALDH2-dependent differences in alcohol metabolism and psychomotor performance: a study in Han Chinese adults after binge drinking

description: Psychomotor impairments due to alcohol consumption may lead to a series of negative consequences. However, the influence of sex and <i>ALDH2</i> polymorphism on psychomotor dysfunction has not yet been investigated. One-hundred and three participants, genotyped for <i>ALDH2</i> rs671, were administered a dose of 1.0 g/kg of white spirits. The blood ethanol concentration (BEC) and acetaldehyde concentration (BAAC) were measured at specific time intervals before and after alcohol consumption. Additionally, auditory simple reaction time (ASRT), visual choice reaction time (VCRT), pursuit tracking task (PTT) and digit-symbol substitution test (DSST) were used to evaluate psychomotor function. Linear mixed-effects model was used to analyze the effects of sex and the <i>ALDH2</i> genotype on alcohol metabolism and psychomotor function.. Acetaldehyde metabolism depended on both <i>ALDH2</i> genotype and sex. Women with <i>ALDH2*1/*1</i> genotype exhibited 2.21 to 18.27 µmol/L higher BAAC levels than men with the same genotype. Conversely, among participants with <i>ALDH2*1/*2</i> genotype, BAAC levels of women were 0.25 to 31.32 µmol/L lower than men. The impact of <i>ALDH2</i> genotype on psychomotor function varied across the four tests. VCRT increased significantly in men with <i>ALDH2*1/*2</i> genotype compared to those with<i> ALDH2*1/*1</i> at 2–4 h post-consumption. In the PTT test, the percentage of time on target decreased by 3.83% and 3.11% in women relative to men at 1 and 2 h post-consumption, respectively. Notably, ASRT performance was significantly correlated with BAAC levels. No effects of <i>ALDH2</i> genotype and sex were observed on DSST performance. <i>ALDH2</i> genotype and sex independently or interactively contribute to alcohol-related psychomotor impairment.
DOI: 10.6084/m9.figshare.30685327
title: Novel insights into predicting the presence of micropapillary and solid components in stage IA lung adenocarcinoma using machine learning models of modifiable risk factors

description: Lung adenocarcinoma (LUAC) patients with micropapillary (MP) and/or solid (S) generally demonstrate a poorer survival prognosis. In the diagnosis and treatment of stage IA LUAC, precisely establishing personalized treatment strategies for patients is crucial for both clinical practice and scientific investigation. Our study aims to develop a novel prediction model based on machine learning (ML) to predict the probability of MP/S patterns in stage IA LUAC patients. Our retrospective analysis was conducted on 1,933 patients diagnosed with stage IA LUAC <i>via</i> postoperative pathological staging, focusing on evaluating MP/S pattern presence. MP/S-positive patients were matched with negative patients at a 1:2 ratio. Univariate logistic regression and Lasso regression were used to select variables with independent prognostic significance. The performance of the traditional logistic regression model was compared with nine ML models based on the identification and calibration. Nodule type, spiculation, Carcinoembryonic antigen level, maximum solid component diameter, median CT value, and CT value range were identified as independent influencing factors for predicting MP/S patterns. The K-Nearest Neighbors (KNN) model performed best among all ten models. The internal validation indicated an area under the curve (AUC) of 0.790, a Brier score of 0.167, and a Hosmer-Lemeshow (HL) test P value of 0.817, while external validation yielded an AUC of 0.790, a Brier score of 0.167, and a HL test P value of 0.120. Shapley additive explanation analysis revealed “nodule type” could alter the predicted probability of MP/S component presence by 13.6%, establishing it as a significant factor. An interpretable KNN model was successfully developed to predict the presence of MP/S components in stage IA LUAC patients, demonstrating superior predictive performance. Accurate evaluation of relevant tumor characteristics possesses substantial clinical significance, as it enables guidance on the optimization of surgical approaches to enhance patient prognosis.
DOI: 10.6084/m9.figshare.30685327.v1
title: Novel insights into predicting the presence of micropapillary and solid components in stage IA lung adenocarcinoma using machine learning models of modifiable risk factors

description: Lung adenocarcinoma (LUAC) patients with micropapillary (MP) and/or solid (S) generally demonstrate a poorer survival prognosis. In the diagnosis and treatment of stage IA LUAC, precisely establishing personalized treatment strategies for patients is crucial for both clinical practice and scientific investigation. Our study aims to develop a novel prediction model based on machine learning (ML) to predict the probability of MP/S patterns in stage IA LUAC patients. Our retrospective analysis was conducted on 1,933 patients diagnosed with stage IA LUAC <i>via</i> postoperative pathological staging, focusing on evaluating MP/S pattern presence. MP/S-positive patients were matched with negative patients at a 1:2 ratio. Univariate logistic regression and Lasso regression were used to select variables with independent prognostic significance. The performance of the traditional logistic regression model was compared with nine ML models based on the identification and calibration. Nodule type, spiculation, Carcinoembryonic antigen level, maximum solid component diameter, median CT value, and CT value range were identified as independent influencing factors for predicting MP/S patterns. The K-Nearest Neighbors (KNN) model performed best among all ten models. The internal validation indicated an area under the curve (AUC) of 0.790, a Brier score of 0.167, and a Hosmer-Lemeshow (HL) test P value of 0.817, while external validation yielded an AUC of 0.790, a Brier score of 0.167, and a HL test P value of 0.120. Shapley additive explanation analysis revealed “nodule type” could alter the predicted probability of MP/S component presence by 13.6%, establishing it as a significant factor. An interpretable KNN model was successfully developed to predict the presence of MP/S components in stage IA LUAC patients, demonstrating superior predictive performance. Accurate evaluation of relevant tumor characteristics possesses substantial clinical significance, as it enables guidance on the optimization of surgical approaches to enhance patient prognosis.
DOI: 10.6084/m9.figshare.30928055.v1
title: Sex- and ALDH2-dependent differences in alcohol metabolism and psychomotor performance: a study in Han Chinese adults after binge drinking

description: Psychomotor impairments due to alcohol consumption may lead to a series of negative consequences. However, the influence of sex and <i>ALDH2</i> polymorphism on psychomotor dysfunction has not yet been investigated. One-hundred and three participants, genotyped for <i>ALDH2</i> rs671, were administered a dose of 1.0 g/kg of white spirits. The blood ethanol concentration (BEC) and acetaldehyde concentration (BAAC) were measured at specific time intervals before and after alcohol consumption. Additionally, auditory simple reaction time (ASRT), visual choice reaction time (VCRT), pursuit tracking task (PTT) and digit-symbol substitution test (DSST) were used to evaluate psychomotor function. Linear mixed-effects model was used to analyze the effects of sex and the <i>ALDH2</i> genotype on alcohol metabolism and psychomotor function.. Acetaldehyde metabolism depended on both <i>ALDH2</i> genotype and sex. Women with <i>ALDH2*1/*1</i> genotype exhibited 2.21 to 18.27 µmol/L higher BAAC levels than men with the same genotype. Conversely, among participants with <i>ALDH2*1/*2</i> genotype, BAAC levels of women were 0.25 to 31.32 µmol/L lower than men. The impact of <i>ALDH2</i> genotype on psychomotor function varied across the four tests. VCRT increased significantly in men with <i>ALDH2*1/*2</i> genotype compared to those with<i> ALDH2*1/*1</i> at 2–4 h post-consumption. In the PTT test, the percentage of time on target decreased by 3.83% and 3.11% in women relative to men at 1 and 2 h post-consumption, respectively. Notably, ASRT performance was significantly correlated with BAAC levels. No effects of <i>ALDH2</i> genotype and sex were observed on DSST performance. <i>ALDH2</i> genotype and sex independently or interactively contribute to alcohol-related psychomotor impairment.
DOI: 10.6084/m9.figshare.28620010
title: Educating women to prevent and treat low back and pelvic girdle pain during and after pregnancy: a systematized narrative review

description: This review evaluated the effectiveness of patient education and information on low back pain (LBP) and pelvic girdle pain (PGP) in pregnant and postpartum women and evaluated their alignment with modern pain education principles rooted in the biopsychosocial model. A systematized narrative review was performed, including a systematic search of three databases and reference screening from relevant systematic reviews. The methodological quality of the included randomized controlled trials (RCT) was evaluated using the PEDro scale. Eighteen studies, including nine RCTs with PEDro scores ranging from to 2–8, indicated that patient education during pregnancy can help reduce pain and related disability. Most studies did not differentiate between LBP and PGP, which limits the specificity and targeted approach of educational interventions. Education alone is less effective without accompanying active treatment. Current programs primarily emphasize biomechanics, covering anatomy and physical changes, but often neglect lifestyle factors, such as stress and sleep. Although patient education is important for managing pregnancy-related LBP and PGP, its effectiveness may be improved by tailoring programs to specific pain conditions and integrating a biopsychosocial perspective on pain. It is important to differentiate between lower back and pelvic girdle pain to specifically address patient education with respect to pain conditions.The incorporation of lifestyle factors such as stress and sleep could be an important part of patient education for both pregnant and postpartum women.Patient education should not stand alone, but should be combined with active treatment, such as exercise.Patient education may be more effective during or at the beginning of pregnancy. It is important to differentiate between lower back and pelvic girdle pain to specifically address patient education with respect to pain conditions. The incorporation of lifestyle factors such as stress and sleep could be an important part of patient education for both pregnant and postpartum women. Patient education should not stand alone, but should be combined with active treatment, such as exercise. Patient education may be more effective during or at the beginning of pregnancy.
DOI: 10.6084/m9.figshare.28620010.v1
title: Educating women to prevent and treat low back and pelvic girdle pain during and after pregnancy: a systematized narrative review

description: This review evaluated the effectiveness of patient education and information on low back pain (LBP) and pelvic girdle pain (PGP) in pregnant and postpartum women and evaluated their alignment with modern pain education principles rooted in the biopsychosocial model. A systematized narrative review was performed, including a systematic search of three databases and reference screening from relevant systematic reviews. The methodological quality of the included randomized controlled trials (RCT) was evaluated using the PEDro scale. Eighteen studies, including nine RCTs with PEDro scores ranging from to 2–8, indicated that patient education during pregnancy can help reduce pain and related disability. Most studies did not differentiate between LBP and PGP, which limits the specificity and targeted approach of educational interventions. Education alone is less effective without accompanying active treatment. Current programs primarily emphasize biomechanics, covering anatomy and physical changes, but often neglect lifestyle factors, such as stress and sleep. Although patient education is important for managing pregnancy-related LBP and PGP, its effectiveness may be improved by tailoring programs to specific pain conditions and integrating a biopsychosocial perspective on pain. It is important to differentiate between lower back and pelvic girdle pain to specifically address patient education with respect to pain conditions.The incorporation of lifestyle factors such as stress and sleep could be an important part of patient education for both pregnant and postpartum women.Patient education should not stand alone, but should be combined with active treatment, such as exercise.Patient education may be more effective during or at the beginning of pregnancy. It is important to differentiate between lower back and pelvic girdle pain to specifically address patient education with respect to pain conditions. The incorporation of lifestyle factors such as stress and sleep could be an important part of patient education for both pregnant and postpartum women. Patient education should not stand alone, but should be combined with active treatment, such as exercise. Patient education may be more effective during or at the beginning of pregnancy.
DOI: 10.6084/m9.figshare.29633884
title: Social determinants of health and age-related differences in all-cause mortality: evidence from National Health and Nutrition Examination Survey

description: Unfavorable social determinants of health (SDoH) are linked to higher risks of poor health, but evidence on their age-specific distribution and association with all-cause mortality are limited. We analyzed NHANES data (2003–2018) from 14,604 participants, stratified by age and cumulative unfavorable SDoH. The association between SDoH and all-cause mortality was assessed using Kaplan–Meier curves, Cox regression models, and restricted cubic spline (RCS) analysis. Among 14,604 participants, 1,835 deaths (8.78%) were recorded. Kaplan–Meier curve analysis showed lower survival rates in the middle and high SDoH groups compared to the low SDoH group. RCS analysis showed a nonlinear relationship between SDoH and all-cause mortality. Cox regression analysis revealed that higher SDoH scores were significantly associated with increased all-cause mortality across all age groups. After full adjustment, each unit increase in SDoH score was linked to a 21% higher mortality risk in young group, 28% in middle-aged group, and 13% in the elderly. Compared to those with low SDoH, individuals in the high SDoH group had the greatest mortality risk in the middle-aged group (HR: 3.10). Distinct SDoH patterns emerged across ages: employment status, food security, and health insurance status were key in young group; middle-aged group were affected by a broader range of SDoH components, while the elderly showed weaker but still significant associations. SDoH characteristics differ across age groups, and unfavorable SDoH are strongly associated with higher all-cause mortality, with age-specific variations. Targeted interventions are needed to address each age group’s unique health needs.