DOI: 10.25550/1-x5g8
title: Gene summary for Dlx5

description: #### Genome Browser Links: [mm9](http://genome.ucsc.edu/cgi-bin/hgTracks?db=mm9&singleSearch=knownCanonical&position=DLX5) | [mm10](http://genome.ucsc.edu/cgi-bin/hgTracks?db=mm10&singleSearch=knownCanonical&position=DLX5) | [hg18](http://genome.ucsc.edu/cgi-bin/hgTracks?db=hg18&singleSearch=knownCanonical&position=DLX5) | [hg19](http://genome.ucsc.edu/cgi-bin/hgTracks?db=hg19&singleSearch=knownCanonical&position=DLX5) #### Reference Images: | E12.5 | E13.5 | E14.5 | E15.5 | |-------|-------|-------|-------| | ![Image](/hatrac/facebase/genesummaries/Dlx5_posterior_E12.5.jpg) | ![Image](/hatrac/facebase/genesummaries/Dlx5_posterior_E13.5.jpg) | ![Image](/hatrac/facebase/genesummaries/Dlx5_posterior_E14.5.jpg) | ![Image](/hatrac/facebase/genesummaries/Dlx5_posterior_E15.5.jpg) | #### Gene expression in the secondary palate: _Dlx5_ is expressed in the nasal mesenchyme along the AP axis of the E13.5 palatal shelf. | | E12.5 | E13.5 | E14.5 | E15.5 | |--------|-------|-------|-------|-------| | **Coronal** | ![Image](/hatrac/facebase/genesummaries/blank.gif) | [![ImageWithSize](/hatrac/facebase/genesummaries/Dlx5_coronal_E13.5_0.jpg){width=100 height=100}](/hatrac/facebase/genesummaries/Dlx5_coronal_E13.5_0.jpg) | ![Image](/hatrac/facebase/genesummaries/blank.gif) |![Image](/hatrac/facebase/genesummaries/blank.gif) | | **Intraoral** | | [![ImageWithSize](/hatrac/facebase/genesummaries/Dlx5_oral_E13.5_0.jpg){width=100 height=100}](/hatrac/facebase/genesummaries/Dlx5_oral_E13.5_0.jpg) | | | N: Nasal Pr: Proximal Di: Distal O: Oral ![Image](/hatrac/facebase/genesummaries/6DC577.gif) Nasal mesenchyme ![Image](/hatrac/facebase/genesummaries/8FBDCD.gif) All mesenchyme (AP axis) #### Sources: - Han et al. (2009) [Indirect modulation of Shh signaling by Dlx5 affects the oral-nasal patterning of palate and rescues cleft palate in Msx1-null mice.](http://www.ncbi.nlm.nih.gov/pubmed/19934017) Development 136(24):4225-33. #### Gene expression in the mandibular and maxillary arches: _Dlx5_ is expressed in the oral epithelium throughout development. | E10.5 | E12.5 | E14.5 | |-------|-------|-------| | [![ImageWithSize](/hatrac/facebase/genesummaries/dlx5-10.5.jpg){width=280 height=214}](/hatrac/facebase/genesummaries/dlx5-10.5.jpg) | [![ImageWithSize](/hatrac/facebase/genesummaries/dlx5-12.5.jpg){width=280 height=214}](/hatrac/facebase/genesummaries/dlx5-12.5.jpg) | [![ImageWithSize](/hatrac/facebase/genesummaries/dlx5-14.5.jpg){width=280 height=214}](/hatrac/facebase/genesummaries/dlx5-14.5.jpg) | | ![Image](/hatrac/facebase/genesummaries/c1b2d1.gif) Proximal mesenchyme | ![Image](/hatrac/facebase/genesummaries/c1b2d1.gif) Osteogenic mesenchyme | ![Image](/hatrac/facebase/genesummaries/c1b2d1.gif) Osteogenic mesenchyme | | | and Meckel’s cartilage | | #### Sources: - Jackson lab. - Unpublished data from Chai’s lab. #### External Links: - [Dlx5 distal-less homeobox 5 [ Mus musculus (house mouse) ]](http://www.ncbi.nlm.nih.gov/gene/13395) - [Dlx5 distal-less homeobox 5 [ Homo sapiens (human) ]](http://www.ncbi.nlm.nih.gov/gene/1749) - [Dlx5 genecard](http://www.genecards.org/cgi-bin/carddisp.pl?gene=DLX5&search=dlx5) - [Dlx5 Wikipedia](http://en.wikipedia.org/wiki/DLX5)