cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.21755526
title: S-allylCysteine Ester/Caffeic Acid Amide Hybrids as Promising Antiprotozoal Candidates: Synthesis, Biological Evaluation and Molecular Modeling Studies

description: Abstract In order to overcome the challenges of discovering new antiprotozoal drugs, we synthesized a new class of hybrids based on S-allylCysteine Ester/Caffeic Acid Amide and evaluated four of them against Trypanosoma cruzi and Plasmodium falciparum. Hybrid 6 exhibited good activity on T. cruzi with an EC50 value of 5.45 µM, whereas hybrid 3 was active over P. falciparum with an EC50 of 18.08 µM. All hybrids displayed a good selectivity index on P. falciparum. Molecular docking computations indicated that several hybrids have good binding affinities towards the protozoa related enzymes (Cruzipain or Falcipain-2) when compared against current inhibitors. In silico studies showed that conjugates 1-3 and 6 fulfilled optimal ADME characteristics, suggesting them as safe alternatives for oral treatment of protozoal infections.
DOI: 10.6084/m9.figshare.21755526.v1
title: S-allylCysteine Ester/Caffeic Acid Amide Hybrids as Promising Antiprotozoal Candidates: Synthesis, Biological Evaluation and Molecular Modeling Studies

description: Abstract In order to overcome the challenges of discovering new antiprotozoal drugs, we synthesized a new class of hybrids based on S-allylCysteine Ester/Caffeic Acid Amide and evaluated four of them against Trypanosoma cruzi and Plasmodium falciparum. Hybrid 6 exhibited good activity on T. cruzi with an EC50 value of 5.45 µM, whereas hybrid 3 was active over P. falciparum with an EC50 of 18.08 µM. All hybrids displayed a good selectivity index on P. falciparum. Molecular docking computations indicated that several hybrids have good binding affinities towards the protozoa related enzymes (Cruzipain or Falcipain-2) when compared against current inhibitors. In silico studies showed that conjugates 1-3 and 6 fulfilled optimal ADME characteristics, suggesting them as safe alternatives for oral treatment of protozoal infections.
DOI: 10.6084/m9.figshare.21755531
title: THEORETICAL AND EXPERIMENTAL STUDY OF STRUCTURE AND REACTIVITY RELATED TO METABOLISM AND TOXICITY OF PARACETAMOL

description: An experimental and theoretical approach on oxidative metabolism of paracetamol was applied for the pharmaceutical chemistry learning. Classical reactions, functional group identification, structural parameter, and chemical reactivity using frontier orbitals and Fukui index were used explaining the main products between N-acetyl-p-benzosemiquinone (NAPQI) and thiolic compounds. The chemoprotection mechanisms by N-acetyl-cysteine on high dosage of paracetamol are consistent with theoretical and experimental results. The methods also described the relationship between the chemical reactivity of quinone-imine system and the induced-toxicity of paracetamol by Michael reaction. These results can be applied in experimental pharmaceutical chemistry teaching.
DOI: 10.6084/m9.figshare.21755531.v1
title: THEORETICAL AND EXPERIMENTAL STUDY OF STRUCTURE AND REACTIVITY RELATED TO METABOLISM AND TOXICITY OF PARACETAMOL

description: An experimental and theoretical approach on oxidative metabolism of paracetamol was applied for the pharmaceutical chemistry learning. Classical reactions, functional group identification, structural parameter, and chemical reactivity using frontier orbitals and Fukui index were used explaining the main products between N-acetyl-p-benzosemiquinone (NAPQI) and thiolic compounds. The chemoprotection mechanisms by N-acetyl-cysteine on high dosage of paracetamol are consistent with theoretical and experimental results. The methods also described the relationship between the chemical reactivity of quinone-imine system and the induced-toxicity of paracetamol by Michael reaction. These results can be applied in experimental pharmaceutical chemistry teaching.
DOI: 10.6084/m9.figshare.21755543
title: Linguistic ethnography in the sociolinguistically complex context of a Western Paraná community: backward into the future of some intersectional applied linguistics

description: ABSTRACT In a chronicle of our increasingly intersectional reflection about a sociolinguistically complex context that we have studied (Jung, 1997, 2003; Jung & Garcez, 2007) having Marilda Cavalcanti as key interlocutor, we look back to earlier work to highlight how the intelligibility we developed about literacy practices in a school community in the West of Paraná has expanded beyond language and gender. In the framework of our reflection on language and political economy (Garcez & Jung, 2021) and particularly in light of the work of Jung and Machado e Silva (2021) on the local festival held annually by the municipality where the school community we studied was located, we revisit our perceptions in a more express and contemporary re-articulation now attentive to axes of differentiation around social class and race. We underscore the privilege of whiteness in our current understandings of local dynamics and in our own positionalities.
DOI: 10.6084/m9.figshare.21755543.v1
title: Linguistic ethnography in the sociolinguistically complex context of a Western Paraná community: backward into the future of some intersectional applied linguistics

description: ABSTRACT In a chronicle of our increasingly intersectional reflection about a sociolinguistically complex context that we have studied (Jung, 1997, 2003; Jung & Garcez, 2007) having Marilda Cavalcanti as key interlocutor, we look back to earlier work to highlight how the intelligibility we developed about literacy practices in a school community in the West of Paraná has expanded beyond language and gender. In the framework of our reflection on language and political economy (Garcez & Jung, 2021) and particularly in light of the work of Jung and Machado e Silva (2021) on the local festival held annually by the municipality where the school community we studied was located, we revisit our perceptions in a more express and contemporary re-articulation now attentive to axes of differentiation around social class and race. We underscore the privilege of whiteness in our current understandings of local dynamics and in our own positionalities.
DOI: 10.6084/m9.figshare.19390769
title: Variation in breeding phenology in response to climate change in two passerine species

description: This paper evaluates how climate change have influenced laying dates of blue- and marsh tits in a population in southern Sweden, from 1983 to 2021. Specifically, we evaluate how daily maximum temperature in an estimated time-window (R package: climwin) and the temperature change in this window influence the duration of breeding season in the two species, i.e. the variation in laying dates within the population. <br> For more info, see README-file.<br>
DOI: 10.6084/m9.figshare.21755552
title: A note on the political economy of exchange rates in Argentina: new and classical developmentalism re-evaluated

description: ABSTRACT The paper develops a model in which the relation between the real exchange rate and the real wage, in the context of conflictive income distribution, is made explicit. It is noted that the central bank tries to regulate the distributive relation exchange rate and real wages through the changes in the interest rate. The theoretical point is that, under certain circumstances, a relatively depreciated or high level of the real exchange rate might reduce real wages and have a negative impact on economic growth. The paper also provides some evidence for the Argentine case, and suggests that the Classical Developmentalist elasticity pessimism seems, in the case of Argentina, to be validated. Also, the use of the exchange rate as an instrument to bolster redistribution away from the working class, and to promote investment and growth is also not born in the data.
DOI: 10.6084/m9.figshare.21755552.v1
title: A note on the political economy of exchange rates in Argentina: new and classical developmentalism re-evaluated

description: ABSTRACT The paper develops a model in which the relation between the real exchange rate and the real wage, in the context of conflictive income distribution, is made explicit. It is noted that the central bank tries to regulate the distributive relation exchange rate and real wages through the changes in the interest rate. The theoretical point is that, under certain circumstances, a relatively depreciated or high level of the real exchange rate might reduce real wages and have a negative impact on economic growth. The paper also provides some evidence for the Argentine case, and suggests that the Classical Developmentalist elasticity pessimism seems, in the case of Argentina, to be validated. Also, the use of the exchange rate as an instrument to bolster redistribution away from the working class, and to promote investment and growth is also not born in the data.
DOI: 10.6084/m9.figshare.21755555
title: Computed tomography assessment of body composition in patients with nonmetastatic breast cancer: what are the best prognostic markers?

description: Abstract Objective: To correlate body composition measures, based on computed tomography (CT) analysis of muscle mass and adipose tissue, with disease-free survival in breast cancer patients. Materials and Methods: This single-center retrospective study included 262 female patients with nonmetastatic breast cancer. Body composition was assessed on a pretreatment CT scan (at the L3 level). The analysis included quantification of the areas of subcutaneous adipose tissue (SAT), visceral adipose tissue (VAT), and skeletal muscle mass, as well as of the mean skeletal muscle density. The VAT/SAT ratio, skeletal mass index (SMI), and skeletal muscle gauge (SMG) were calculated. Results: Of the 262 patients evaluated, 175 (66.8%) were classified as overweight or obese on the basis of their body mass index. We observed low SMI in 35 patients (13.4%) and elevated VAT in 123 (46.9%). Disease-free survival was significantly shorter in the patients who underwent neoadjuvant chemotherapy (p = 0.044), in those with a low SMI (p = 0.006), in those with low SMG (p = 0.013), and in those with a low VAT/SAT ratio (p = 0.050). In a multivariate analysis, only SMG, the VAT/SAT ratio, and having undergone neoadjuvant chemotherapy retained their statistical significance. Conclusion: Our results confirm that low SMG and the VAT/SAT ratio can be used as imaging biomarkers to assess prognosis in patients with nonmetastatic breast cancer.
DOI: 10.6084/m9.figshare.21755555.v1
title: Computed tomography assessment of body composition in patients with nonmetastatic breast cancer: what are the best prognostic markers?

description: Abstract Objective: To correlate body composition measures, based on computed tomography (CT) analysis of muscle mass and adipose tissue, with disease-free survival in breast cancer patients. Materials and Methods: This single-center retrospective study included 262 female patients with nonmetastatic breast cancer. Body composition was assessed on a pretreatment CT scan (at the L3 level). The analysis included quantification of the areas of subcutaneous adipose tissue (SAT), visceral adipose tissue (VAT), and skeletal muscle mass, as well as of the mean skeletal muscle density. The VAT/SAT ratio, skeletal mass index (SMI), and skeletal muscle gauge (SMG) were calculated. Results: Of the 262 patients evaluated, 175 (66.8%) were classified as overweight or obese on the basis of their body mass index. We observed low SMI in 35 patients (13.4%) and elevated VAT in 123 (46.9%). Disease-free survival was significantly shorter in the patients who underwent neoadjuvant chemotherapy (p = 0.044), in those with a low SMI (p = 0.006), in those with low SMG (p = 0.013), and in those with a low VAT/SAT ratio (p = 0.050). In a multivariate analysis, only SMG, the VAT/SAT ratio, and having undergone neoadjuvant chemotherapy retained their statistical significance. Conclusion: Our results confirm that low SMG and the VAT/SAT ratio can be used as imaging biomarkers to assess prognosis in patients with nonmetastatic breast cancer.
DOI: 10.6084/m9.figshare.21755556
title: Artificial Intelligence and employment: a systematic review

description: ABSTRACT This paper presents a systematic literature review, grounded on bibliometric procedures, of the (political economy) works, produced from 2008 to 2020, on the relations between Artificial Intelligence and employment. It detects a growing tendency of published papers in this field, especially from 2019, and identifies four main groups of concerns on this topic. Within these groups, a prevalence of more optimistic over skeptical accounts and, especially, of economic orthodox over heterodox approaches on the issue can be noted. Overall, it is possible to understand that both the reviewed works and their metrics are quite dispersed and varied in scope. Among other reasons, this is due to the lack of a common basic definition, within the field, of AI in the first place.
DOI: 10.6084/m9.figshare.21755558
title: “Who killed Diego?”: scalar projections in onlineOffline semiotic landscapes

description: ABSTRACT This article investigates scalar projections in onlineOffline semiotic landscapes, in which meanings about the murder of a gay and black student, Diego Machado, on a university campus are located and performed. Especially, it historicizes ‘the spirit of our socially fascist times’ that accentuates the discourses about which bodies are allowed to live and which must die. Such historicization operates as a backdrop against which particular scalar semiotic exercises, indexically marked, are made possible. In concluding, the article argues for the need of theorizing hope as emotion, enabling perennial resistance, in response to our ethical responsibility.
DOI: 10.6084/m9.figshare.21755558.v1
title: “Who killed Diego?”: scalar projections in onlineOffline semiotic landscapes

description: ABSTRACT This article investigates scalar projections in onlineOffline semiotic landscapes, in which meanings about the murder of a gay and black student, Diego Machado, on a university campus are located and performed. Especially, it historicizes ‘the spirit of our socially fascist times’ that accentuates the discourses about which bodies are allowed to live and which must die. Such historicization operates as a backdrop against which particular scalar semiotic exercises, indexically marked, are made possible. In concluding, the article argues for the need of theorizing hope as emotion, enabling perennial resistance, in response to our ethical responsibility.
DOI: 10.6084/m9.figshare.21755559
title: Current account and real exchange rate equilibrium: the case of manufacturing in Mexico, 2001-2019

description: ABSTRACT In this paper, we follow Bresser-Pereira et al. (2021) and estimate for Mexico a a series of the real exchange rate (RER) that balances the current account for Mexico for the period 2001q1-2019q4. In this process we take into account numerous determinants, including policy variables and financial indicators the evolution of the terms of trade, as well as a proxi for the Balassa-Samuelson effects, inter alia. Our results show that in most of the period analyzed there has been a trend tendency towards overvaluation, with the RER fluctuating above its equilibrium level. With cointegrating methods, and dynamic ordinary least squared (DOLS) techniques, we examined the effects of exchange rate under and overvaluation on manufacturing; disaggregated in three sectors: i) technology intensive, ii) natural resource intensive and iii) labor intensive activities. Overall, our results indicate that the real exchange rate has a significant influence on the rate of expansion of Mexico’s manufacturing real GDP.
DOI: 10.6084/m9.figshare.21755559.v1
title: Current account and real exchange rate equilibrium: the case of manufacturing in Mexico, 2001-2019

description: ABSTRACT In this paper, we follow Bresser-Pereira et al. (2021) and estimate for Mexico a a series of the real exchange rate (RER) that balances the current account for Mexico for the period 2001q1-2019q4. In this process we take into account numerous determinants, including policy variables and financial indicators the evolution of the terms of trade, as well as a proxi for the Balassa-Samuelson effects, inter alia. Our results show that in most of the period analyzed there has been a trend tendency towards overvaluation, with the RER fluctuating above its equilibrium level. With cointegrating methods, and dynamic ordinary least squared (DOLS) techniques, we examined the effects of exchange rate under and overvaluation on manufacturing; disaggregated in three sectors: i) technology intensive, ii) natural resource intensive and iii) labor intensive activities. Overall, our results indicate that the real exchange rate has a significant influence on the rate of expansion of Mexico’s manufacturing real GDP.
DOI: 10.6084/m9.figshare.21755561
title: Asymptomatic HIV-Infected Patients Present Blood Parameters Changed, According to Use of Therapy and the CD4+ T Cells Count

description: Abstract In HIV-patients, the imbalance in immunological, hematological and biochemical factors can contribute to the progression to AIDS and non-AIDS comorbidities, even during combined antiretroviral therapy (cART). In this cross-sectional study, we aimed to analyze some of these parameters in 138 different asymptomatic HIV-infected patients, doing multiple comparisons between the groups, which are dichotomized in the presence / absence of cART and type of immune response (immunological responders [iR,&gt;500cells/mL] or non-responders [iNR,&lt;500cells/ mL]). Were analyzed cytokines and other routine laboratory parameters. Our results showed high creatine phosphokinase and low IL-10 levels in cART-patients. They also presented metabolic alterations, including elevations in total cholesterol and triglycerides, particularly in those iNR. In ART-iR an increased alanine aminotransferase was observed. Those NAÏVE-iNR presented high LDL-cholesterol, C-reactive protein and lactate dehydrogenase values. The long-term non-progressors (LTNP) showed the best laboratory results. In conclusion, many blood parameters were changed in HIV-patients, especially in those under cART. To identify LTNP individuals could be important to discussions their early therapeutic onset.
DOI: 10.6084/m9.figshare.21755561.v1
title: Asymptomatic HIV-Infected Patients Present Blood Parameters Changed, According to Use of Therapy and the CD4+ T Cells Count

description: Abstract In HIV-patients, the imbalance in immunological, hematological and biochemical factors can contribute to the progression to AIDS and non-AIDS comorbidities, even during combined antiretroviral therapy (cART). In this cross-sectional study, we aimed to analyze some of these parameters in 138 different asymptomatic HIV-infected patients, doing multiple comparisons between the groups, which are dichotomized in the presence / absence of cART and type of immune response (immunological responders [iR,&gt;500cells/mL] or non-responders [iNR,&lt;500cells/ mL]). Were analyzed cytokines and other routine laboratory parameters. Our results showed high creatine phosphokinase and low IL-10 levels in cART-patients. They also presented metabolic alterations, including elevations in total cholesterol and triglycerides, particularly in those iNR. In ART-iR an increased alanine aminotransferase was observed. Those NAÏVE-iNR presented high LDL-cholesterol, C-reactive protein and lactate dehydrogenase values. The long-term non-progressors (LTNP) showed the best laboratory results. In conclusion, many blood parameters were changed in HIV-patients, especially in those under cART. To identify LTNP individuals could be important to discussions their early therapeutic onset.
DOI: 10.6084/m9.figshare.21755537
title: Data for Polarization-independent wavelength demultiplexer based on a single etched diffraction grating device.zip

description: Data for Polarization-independent wavelength demultiplexer based on a single etched diffraction grating device.
DOI: 10.6084/m9.figshare.21755537.v1
title: Data for Polarization-independent wavelength demultiplexer based on a single etched diffraction grating device.zip

description: Data for Polarization-independent wavelength demultiplexer based on a single etched diffraction grating device.
DOI: 10.6084/m9.figshare.21755564
title: Molecular evolution and diversification of phytoene synthase (PSY) gene family

description: Abstract Phytoene synthase (PSY) is a crucial enzyme required for carotenoid biosynthesis, encoded by a gene family conserved in carotenoid-producing organisms. This gene family is diversified in angiosperms through distinct duplication events. Understanding diversification patterns and the evolutionary history of the PSY gene family is important for explaining carotenogenesis in different plant tissues. This study identified 351 PSY genes in 166 species, including Viridiplantae, brown and red algae, cyanobacteria, fungi, arthropods, and bacteria. All PSY genes displayed conserved intron/exon organization. Fungi and arthropod PSY sequences were grouped with prokaryote PSY, suggesting the occurrence of horizontal gene transfer. Angiosperm PSY is split into five subgroups. One includes the putative ortholog of PSY3 (Subgroup E3) from eudicots, and the other four subgroups include PSY from both monocots and eudicots (subgroups E1, E2, M1, and M2). Expression profile analysis revealed that PSY genes are constitutively expressed across developmental stages and anatomical parts, except for the eudicot PSY3, with root-specific expression. This study elucidates the molecular evolution and diversification of the PSY gene family, furthering our understanding of variations in carotenogenesis.
DOI: 10.6084/m9.figshare.21755564.v1
title: Molecular evolution and diversification of phytoene synthase (PSY) gene family

description: Abstract Phytoene synthase (PSY) is a crucial enzyme required for carotenoid biosynthesis, encoded by a gene family conserved in carotenoid-producing organisms. This gene family is diversified in angiosperms through distinct duplication events. Understanding diversification patterns and the evolutionary history of the PSY gene family is important for explaining carotenogenesis in different plant tissues. This study identified 351 PSY genes in 166 species, including Viridiplantae, brown and red algae, cyanobacteria, fungi, arthropods, and bacteria. All PSY genes displayed conserved intron/exon organization. Fungi and arthropod PSY sequences were grouped with prokaryote PSY, suggesting the occurrence of horizontal gene transfer. Angiosperm PSY is split into five subgroups. One includes the putative ortholog of PSY3 (Subgroup E3) from eudicots, and the other four subgroups include PSY from both monocots and eudicots (subgroups E1, E2, M1, and M2). Expression profile analysis revealed that PSY genes are constitutively expressed across developmental stages and anatomical parts, except for the eudicot PSY3, with root-specific expression. This study elucidates the molecular evolution and diversification of the PSY gene family, furthering our understanding of variations in carotenogenesis.