cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.5281/zenodo.18773163
title: PREVALENCE AND ETIOLOGICAL AGENTS OF BACTERIAL MENINGITIS IN CHILDREN: A GLOBAL, SOUTH ASIAN, AND CENTRAL ASIAN PERSPECTIVE

description: Bacterial meningitis remains a major cause of morbidity and mortality in children worldwide, particularly among those under five years of age.¹ Despite substantial reductions in incidence following the introduction of conjugate vaccines, the disease continues to impose a significant burden in low- and middle-income countries.² This review summarizes current evidence on the prevalence and causative organisms of pediatric bacterial meningitis globally, with focused discussion on South Asia and Central Asia. Globally, Streptococcus pneumoniae, Neisseria meningitidis, and Haemophilus influenzae type b (Hib) remain the principal pathogens beyond the neonatal period, while Group B Streptococcus and gram-negative bacilli predominate in neonates.³ South Asia continues to report relatively higher incidence rates compared to high-income regions, although vaccine introduction has substantially reduced Hib disease.⁵ Data from Central Asia remain limited, highlighting the need for strengthened surveillance systems.⁸ Sustained vaccination coverage, improved laboratory diagnostics, and regional epidemiological monitoring are critical to further reduce disease burden.²
DOI: 10.5281/zenodo.18773164
title: PREVALENCE AND ETIOLOGICAL AGENTS OF BACTERIAL MENINGITIS IN CHILDREN: A GLOBAL, SOUTH ASIAN, AND CENTRAL ASIAN PERSPECTIVE

description: Bacterial meningitis remains a major cause of morbidity and mortality in children worldwide, particularly among those under five years of age.¹ Despite substantial reductions in incidence following the introduction of conjugate vaccines, the disease continues to impose a significant burden in low- and middle-income countries.² This review summarizes current evidence on the prevalence and causative organisms of pediatric bacterial meningitis globally, with focused discussion on South Asia and Central Asia. Globally, Streptococcus pneumoniae, Neisseria meningitidis, and Haemophilus influenzae type b (Hib) remain the principal pathogens beyond the neonatal period, while Group B Streptococcus and gram-negative bacilli predominate in neonates.³ South Asia continues to report relatively higher incidence rates compared to high-income regions, although vaccine introduction has substantially reduced Hib disease.⁵ Data from Central Asia remain limited, highlighting the need for strengthened surveillance systems.⁸ Sustained vaccination coverage, improved laboratory diagnostics, and regional epidemiological monitoring are critical to further reduce disease burden.²
DOI: 10.5281/zenodo.14898699
title: Multi-omic Characterization of Longitudinal Tumor Specimens Reveals Co-evolution of Metastatic Melanoma and Tumor Immune Microenvironment Under Therapeutic Pressure

description: In this study, we comprehensively analyzed 45 longitudinal tumor samples from 10 patients with metastatic melanoma who progressed on sequential targeted and ICB therapies.
DOI: 10.5281/zenodo.18772719
title: Figuras en alta resolución asociadas a la tesis: Generación y validación del primer genoma a nivel cromosómico del Bagre rayado Pseudoplatystoma magdaleniatum (Siluriformes, Pimelodidae)

description: Este conjunto de datos contiene versiones en alta resolución de figuras incluidas en la tesis de Maestría titulada:

“Generación y validación del primer genoma a nivel cromosómico del Bagre rayado Pseudoplatystoma magdaleniatum (Siluriformes, Pimelodidae)”, presentada en el Programa de Maestría en Bioinformática (PEDECIBA, Universidad de la República, Uruguay, 2026).

Las figuras corresponden a visualizaciones generadas durante el proceso de ensamblaje, validación estructural, anotación funcional y comparación genómica del primer genoma cromosómico disponible para Pseudoplatystoma magdaleniatum, especie migratoria de importancia ecológica y socioeconómica en la cuenca Magdalena–Cauca (Colombia).

El depósito incluye:





Dotplots de comparación estructural entre ensamblajes intermedios y el ensamblaje final.




Mapa de anotación del genoma nuclear.




Anotación del genoma mitocondrial completo.




Filogenia basada en mitogenomas completos de Siluriformes.




Comparaciones genómicas intrafamiliares mediante alineamientos a gran escala.



Estas imágenes se depositan en formato de alta resolución debido a que el nivel de detalle puede verse limitado en el documento PDF principal de la tesis.

El objetivo de este depósito es garantizar la disponibilidad pública de las visualizaciones originales, facilitar su inspección detallada y promover la transparencia metodológica.
DOI: 10.5281/zenodo.18772718
title: Figuras en alta resolución asociadas a la tesis: Generación y validación del primer genoma a nivel cromosómico del Bagre rayado Pseudoplatystoma magdaleniatum (Siluriformes, Pimelodidae)

description: Este conjunto de datos contiene versiones en alta resolución de figuras incluidas en la tesis de Maestría titulada:

“Generación y validación del primer genoma a nivel cromosómico del Bagre rayado Pseudoplatystoma magdaleniatum (Siluriformes, Pimelodidae)”, presentada en el Programa de Maestría en Bioinformática (PEDECIBA, Universidad de la República, Uruguay, 2026).

Las figuras corresponden a visualizaciones generadas durante el proceso de ensamblaje, validación estructural, anotación funcional y comparación genómica del primer genoma cromosómico disponible para Pseudoplatystoma magdaleniatum, especie migratoria de importancia ecológica y socioeconómica en la cuenca Magdalena–Cauca (Colombia).

El depósito incluye:





Dotplots de comparación estructural entre ensamblajes intermedios y el ensamblaje final.




Mapa de anotación del genoma nuclear.




Anotación del genoma mitocondrial completo.




Filogenia basada en mitogenomas completos de Siluriformes.




Comparaciones genómicas intrafamiliares mediante alineamientos a gran escala.



Estas imágenes se depositan en formato de alta resolución debido a que el nivel de detalle puede verse limitado en el documento PDF principal de la tesis.

El objetivo de este depósito es garantizar la disponibilidad pública de las visualizaciones originales, facilitar su inspección detallada y promover la transparencia metodológica.
DOI: 10.6084/m9.figshare.31410981
title: <b>Development of cognition in corvids</b>

description: Corvids - members of the crow family - exhibit some of the most sophisticated cognitive abilities outside the primate lineage, yet the developmental origins of many of these abilities remain poorly understood. Here, we present a systematic review of the past 20 years (2005-2025) of empirical research on corvid cognitive development, synthesising evidence across core/ foundational, social and physical cognitive domains. Using a structured search strategy and detailed coding framework, we evaluate and discuss developmental trajectories, species/ taxa-level variation and methodological robustness across studies. Across domains, corvid developmental patterns show both parallels and divergences from those documented in non-human primates, children and other taxa, yet the existing corvid evidence base is constrained by small samples, captive biases, limited longitudinal data and under-representation of key cognitive abilities, such as executive function, causal reasoning, self-control, metacognition, spatial memory and social learning. We outline critical gaps and future directions, emphasising the need for comparative, longitudinal and ecologically grounded approaches to better understand how early-life cognition shapes later behaviour, cognition and fitness in this model avian family.
DOI: 10.6084/m9.figshare.31410981.v1
title: <b>Development of cognition in corvids</b>

description: Corvids - members of the crow family - exhibit some of the most sophisticated cognitive abilities outside the primate lineage, yet the developmental origins of many of these abilities remain poorly understood. Here, we present a systematic review of the past 20 years (2005-2025) of empirical research on corvid cognitive development, synthesising evidence across core/ foundational, social and physical cognitive domains. Using a structured search strategy and detailed coding framework, we evaluate and discuss developmental trajectories, species/ taxa-level variation and methodological robustness across studies. Across domains, corvid developmental patterns show both parallels and divergences from those documented in non-human primates, children and other taxa, yet the existing corvid evidence base is constrained by small samples, captive biases, limited longitudinal data and under-representation of key cognitive abilities, such as executive function, causal reasoning, self-control, metacognition, spatial memory and social learning. We outline critical gaps and future directions, emphasising the need for comparative, longitudinal and ecologically grounded approaches to better understand how early-life cognition shapes later behaviour, cognition and fitness in this model avian family.
DOI: 10.5281/zenodo.14899123
title: Multi-omic Characterization of Longitudinal Tumor Specimens Reveals Co-evolution of Metastatic Melanoma and Tumor Immune Microenvironment Under Therapeutic Pressure

description: In this study, we comprehensively analyzed 45 longitudinal tumor samples from 10 patients with metastatic melanoma who progressed on sequential targeted and ICB therapies.
DOI: 10.5281/zenodo.18773193
title: ISSUESOFENHANCINGTHEINTELLECTUALPOTENTIALOFWOMENINUZBEKISTAN:PHILOSOPHICALANDSOCIALANALYSIS

description: ThisarticlestudiestheissueofimprovingtheintellectualpotentialofwomeninUzbekistanfromaphilosophicalandsocio-analyticalpointofview.Thestudyanalyzesthephilosophicalessenceoftheconceptoffemaleintelligence,itsroleinthedevelopmentofsociety,anditshistoricalandculturalfoundations.Inparticular,theinterpretationoffemaleintellectualmaturityintheviewsofEasternthinkers,theharmonyofnationalvaluesandmodernsocialreformsarehighlighted.Thearticleidentifiescultural-mental,axiologicalandpsychologicalfactorsthat,alongwiththeincreasingactivityofwomenineducation,scienceandsociallifeinUzbekistanduringtheyearsofindependence,preventthemfromfullyrealizingtheirintellectualpotential.Theseproblemsareanalyzedbasedonaphilosophicalapproachandtheneedtoformwomenasactiveintellectualsubjectsofsocietyissubstantiated
DOI: 10.5281/zenodo.14898698
title: Multi-omic Characterization of Longitudinal Tumor Specimens Reveals Co-evolution of Metastatic Melanoma and Tumor Immune Microenvironment Under Therapeutic Pressure

description: In this study, we comprehensively analyzed 45 longitudinal tumor samples from 10 patients with metastatic melanoma who progressed on sequential targeted and ICB therapies.
DOI: 10.5281/zenodo.18773192
title: ISSUESOFENHANCINGTHEINTELLECTUALPOTENTIALOFWOMENINUZBEKISTAN:PHILOSOPHICALANDSOCIALANALYSIS

description: ThisarticlestudiestheissueofimprovingtheintellectualpotentialofwomeninUzbekistanfromaphilosophicalandsocio-analyticalpointofview.Thestudyanalyzesthephilosophicalessenceoftheconceptoffemaleintelligence,itsroleinthedevelopmentofsociety,anditshistoricalandculturalfoundations.Inparticular,theinterpretationoffemaleintellectualmaturityintheviewsofEasternthinkers,theharmonyofnationalvaluesandmodernsocialreformsarehighlighted.Thearticleidentifiescultural-mental,axiologicalandpsychologicalfactorsthat,alongwiththeincreasingactivityofwomenineducation,scienceandsociallifeinUzbekistanduringtheyearsofindependence,preventthemfromfullyrealizingtheirintellectualpotential.Theseproblemsareanalyzedbasedonaphilosophicalapproachandtheneedtoformwomenasactiveintellectualsubjectsofsocietyissubstantiated
DOI: 10.5281/zenodo.18267827
title: Integration of distal tibial shape and internal trabecular bone structure among catarrhine primates

description: Dataset and code for Journal article "Integration of distal tibial shape and internal trabecular bone structure in the primate distal tibia"Corresponding Author: Dr. Annalisa Pietrobelli (annalisa_pietrobelli@eva.mpg.de); Article DOI: 10.1098/rspb.2026.0126; Journal: Proceedings of the Royal Society B
DOI: 10.5281/zenodo.18768300
title: Integration of distal tibial shape and internal trabecular bone structure among catarrhine primates

description: Dataset and code for Journal article "Integration of distal tibial shape and internal trabecular bone structure in the primate distal tibia"Corresponding Author: Dr. Annalisa Pietrobelli (annalisa_pietrobelli@eva.mpg.de); Article DOI: 10.1098/rspb.2026.0126; Journal: Proceedings of the Royal Society B
DOI: 10.6084/m9.figshare.31119099
title: Serology-based diagnosis of coeliac disease in secondary care: a single-centre study in Norway

description: Coeliac disease (CeD) affects 1–2% of the western population. Diagnosis is based on serology and duodenal biopsy, but serology-based diagnosis in adults has been approved in Europe. To evaluate the diagnostic performance of IgA anti-transglutaminase 2 (IgA-TG2) and IgG anti-deamidated gliadin peptides (IgG-DGP), and their combinations, compared with biopsy in a real-world secondary care setting. Adult patients referred to secondary care endoscopy service at Oslo University Hospital for suspected CeD were invited to participate. CeD diagnosis followed European and Norwegian guidelines, requiring positive serology and mucosal damage. Among 312 evaluable patients, 215 were diagnosed with CeD between 2018 and 2024. Analysis of IgA-TG2 above threshold (&gt;4 U/ml) showed 93% specificity and 94% sensitivity, while IgG-DGP (&gt;20 U/ml) showed 88% specificity and 83% sensitivity. In ROC analyses, the AUC values were 0.98 and 0.95, respectively. Higher threshold (2x, 3x, 5x and 10x ULN) of IgA-TG2 increased specificity (99% to 100%) but lowered sensitivity (82% to 49%). Using IgG-DGP did not increase specificity but detected six missed CeD cases by IgA-TG2. Forty-two percent (<i>n</i> = 92) of cases could be diagnosed with a no-biopsy approach with 10x ULN IgA-TG2 at referral with 100% specificity. Serology correlates strongly with histological changes, supporting diagnosis without gastroscopy. A 10x ULN threshold shows excellent specificity at the expense of sensitivity, thus lower thresholds may be preferable due to diminishing gains in specificity. IgG-DGP serves as a valuable complementary marker, that improves sensitivity and helps identify patients with weak IgA-TG2 responses. Adults evaluated for suspected coeliac disease (n = 312). Demographics, serology, and duodenal histology were analysed. The scatter shows IgA-TG2 vs IgG-DGP at biopsy day, with ULN (1x) lines. Created in BioRender. Ibsen, J. (2026) https://BioRender.com/fw3og7w.
DOI: 10.6084/m9.figshare.31119099.v1
title: Serology-based diagnosis of coeliac disease in secondary care: a single-centre study in Norway

description: Coeliac disease (CeD) affects 1–2% of the western population. Diagnosis is based on serology and duodenal biopsy, but serology-based diagnosis in adults has been approved in Europe. To evaluate the diagnostic performance of IgA anti-transglutaminase 2 (IgA-TG2) and IgG anti-deamidated gliadin peptides (IgG-DGP), and their combinations, compared with biopsy in a real-world secondary care setting. Adult patients referred to secondary care endoscopy service at Oslo University Hospital for suspected CeD were invited to participate. CeD diagnosis followed European and Norwegian guidelines, requiring positive serology and mucosal damage. Among 312 evaluable patients, 215 were diagnosed with CeD between 2018 and 2024. Analysis of IgA-TG2 above threshold (&gt;4 U/ml) showed 93% specificity and 94% sensitivity, while IgG-DGP (&gt;20 U/ml) showed 88% specificity and 83% sensitivity. In ROC analyses, the AUC values were 0.98 and 0.95, respectively. Higher threshold (2x, 3x, 5x and 10x ULN) of IgA-TG2 increased specificity (99% to 100%) but lowered sensitivity (82% to 49%). Using IgG-DGP did not increase specificity but detected six missed CeD cases by IgA-TG2. Forty-two percent (<i>n</i> = 92) of cases could be diagnosed with a no-biopsy approach with 10x ULN IgA-TG2 at referral with 100% specificity. Serology correlates strongly with histological changes, supporting diagnosis without gastroscopy. A 10x ULN threshold shows excellent specificity at the expense of sensitivity, thus lower thresholds may be preferable due to diminishing gains in specificity. IgG-DGP serves as a valuable complementary marker, that improves sensitivity and helps identify patients with weak IgA-TG2 responses. Adults evaluated for suspected coeliac disease (n = 312). Demographics, serology, and duodenal histology were analysed. The scatter shows IgA-TG2 vs IgG-DGP at biopsy day, with ULN (1x) lines. Created in BioRender. Ibsen, J. (2026) https://BioRender.com/fw3og7w.
DOI: 10.6084/m9.figshare.31119102
title: Liver enzyme alterations during pregnancy in IBD are not attributable to disease activity or medication

description: Inflammatory bowel disease (IBD) is often diagnosed during reproductive age, requiring adequate management during pregnancy. Physiological changes during pregnancy affect liver enzymes, complicating interpretation in a population prone to liver test abnormalities. This study aims to investigate liver enzyme trends throughout pregnancy in women with IBD. A retrospective cohort study was conducted in three Dutch university hospitals. Pregnant women with IBD were included; liver enzyme levels were analyzed throughout pregnancy using Bayesian modeling. The association between liver enzymes and IBD disease activity, medication, pregnancy and adverse pregnancy outcomes was assessed, with estimated marginal means (EMMs) reported across trimesters and clinical subgroups. Liver enzyme levels exhibited significant trimester-specific variations in pregnant individuals with IBD. Levels of aminotransferases, γ-glutamyl transferase (γGT) and bilirubin generally declined, particularly in the second trimester, whereas alkaline phosphatase (ALP) levels increased markedly in the third trimester, mirroring physiological changes observed in healthy pregnancies. Adverse pregnancy outcomes were not associated with differences in liver enzyme levels. Several medications – particularly ustekinumab, vedolizumab, thiopurines, corticosteroids and amino salicylates – were associated with liver enzyme values or interacted with pregnancy, modulating the direction or magnitude of change. However, these effects were generally modest and remained within reference values. In pregnant women with IBD, changes in liver enzyme levels reflect physiological gestational adaptations rather than pharmacologic effects. Although medication-specific interactions were detected, their clinical significance appears limited. Marked elevations in liver enzymes during pregnancy cannot routinely be attributed to IBD activity or medication and warrant urgent analysis. Liver enzyme changes in pregnant women with IBD reflect physiological adaptation. Medication effects were modest. Liver tests should be interpreted in context over time. Marked elevations are unlikely to be due to IBD or medication and require further evaluation. <i>What is already known?</i>Liver enzyme levels change during pregnancy and may complicate monitoring in women with IBD. <i>What is new here?</i>This first study on liver enzymes in pregnant women with IBD identifies trimester-specific liver enzyme trends in pregnant women with IBD, largely reflecting physiological changes rather than disease or medication effects. <i>How can this help patient care?</i>Marked elevations in liver enzymes during pregnancy cannot routinely be attributed to IBD activity or medication and warrant urgent analysis. Understanding normal liver enzyme trends in IBD pregnancies aids clinicians in distinguishing physiological adaptations from pathology, improving interpretation of liver function tests during pregnancy.
DOI: 10.6084/m9.figshare.31119102.v1
title: Liver enzyme alterations during pregnancy in IBD are not attributable to disease activity or medication

description: Inflammatory bowel disease (IBD) is often diagnosed during reproductive age, requiring adequate management during pregnancy. Physiological changes during pregnancy affect liver enzymes, complicating interpretation in a population prone to liver test abnormalities. This study aims to investigate liver enzyme trends throughout pregnancy in women with IBD. A retrospective cohort study was conducted in three Dutch university hospitals. Pregnant women with IBD were included; liver enzyme levels were analyzed throughout pregnancy using Bayesian modeling. The association between liver enzymes and IBD disease activity, medication, pregnancy and adverse pregnancy outcomes was assessed, with estimated marginal means (EMMs) reported across trimesters and clinical subgroups. Liver enzyme levels exhibited significant trimester-specific variations in pregnant individuals with IBD. Levels of aminotransferases, γ-glutamyl transferase (γGT) and bilirubin generally declined, particularly in the second trimester, whereas alkaline phosphatase (ALP) levels increased markedly in the third trimester, mirroring physiological changes observed in healthy pregnancies. Adverse pregnancy outcomes were not associated with differences in liver enzyme levels. Several medications – particularly ustekinumab, vedolizumab, thiopurines, corticosteroids and amino salicylates – were associated with liver enzyme values or interacted with pregnancy, modulating the direction or magnitude of change. However, these effects were generally modest and remained within reference values. In pregnant women with IBD, changes in liver enzyme levels reflect physiological gestational adaptations rather than pharmacologic effects. Although medication-specific interactions were detected, their clinical significance appears limited. Marked elevations in liver enzymes during pregnancy cannot routinely be attributed to IBD activity or medication and warrant urgent analysis. Liver enzyme changes in pregnant women with IBD reflect physiological adaptation. Medication effects were modest. Liver tests should be interpreted in context over time. Marked elevations are unlikely to be due to IBD or medication and require further evaluation. <i>What is already known?</i>Liver enzyme levels change during pregnancy and may complicate monitoring in women with IBD. <i>What is new here?</i>This first study on liver enzymes in pregnant women with IBD identifies trimester-specific liver enzyme trends in pregnant women with IBD, largely reflecting physiological changes rather than disease or medication effects. <i>How can this help patient care?</i>Marked elevations in liver enzymes during pregnancy cannot routinely be attributed to IBD activity or medication and warrant urgent analysis. Understanding normal liver enzyme trends in IBD pregnancies aids clinicians in distinguishing physiological adaptations from pathology, improving interpretation of liver function tests during pregnancy.
DOI: 10.15468/dl.rwczgb
title: Occurrence Download

description: A dataset containing 207094 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Castor fiber)",
 "Year is one of (2010, 2011, 2012, 2013, 2014, 2015, 2016, 2017, 2018, 2019, 2020, 2021, 2022, 2023, 2024)",
 "DecimalLatitude is greater than or equal to 44.95782311925129",
 "DecimalLatitude is less than or equal to 58.30331634439415",
 "DecimalLongitude is greater than or equal to -10.001896207643075",
 "DecimalLongitude is less than or equal to 30.31691447027875",
 "Year is not null",
 "HasCoordinate is TRUE",
 "OccurrenceStatus is Present",
 "HasGeospatialIssue is FALSE",
 "BasisOfRecord is one of (Human Observation, Occurrence evidence)"
 ]
}

 The dataset includes 207094 records from 254 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0000152-260225131425191/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.