cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.5286/isis.e.rb2510388-1
title: Characterizing lipid nanocarriers (LNCs) for targeting intracellular delivery of siRNA

description: Gene therapy by RNA interference is rapidly developing as a personal field of cancer treatment. Small interfering RNA (siRNA) plays a key role, enabling the targeting of disease-causing proteins. The successful application of siRNA relies heavily on efficient delivery systems. Lipid nanocarriers (LNCs) are used as drug delivery systems. However, tissue-specific targeting remains a key challenge to overcome. In this regard, we aim to design T7 peptide-functionalized liposomes, known for their ability to bind to the human transferrin receptor (hTfR), highly expressed on both the blood-brain barrier and blood–tumor barrier for glioma. A modified T7 peptide was synthesized and the highly selective thiol-maleimide reaction was chosen for further functionalization to DOPE-PEG2000-Mal. DOPE-PEG2000-Mal-T7 will be used as an LNCs substituent, with DPPC, DOTAP and cholesterol. By SANS measurements, exploiting the contrast-matching technique by using hydrogenated and deuterated lipids as components of the LNCs, we aim to understand where DOPE-PEG2000-Mal-T7 is located and the interaction between LNCs and hTfR.
DOI: 10.3535/gmj-acp-f8y
title: Lonicera xylosteum L.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/mkp-kb9-8dh
title: Solanum flagellare Sendtn.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.5286/isis.e.rb2420104-2
title: Polarized small-angle neutron scattering study of skyrmions in bulk nanocrystalline MnSi

description: It is crucial to understand the fundamental physics behind the origin and stability of skyrmions due to their potential for various quantum applications. It is also equally important to develop efficient experimental techniques to detect skyrmions in diverse material forms, such as thin films, single crystals, or nanoparticles. While attempts have been made to stabilize skyrmions in a wider temperature and magnetic field range e.g. by reducing the system dimensionality, conclusive evidence for the skyrmion phase in low-dimensional systems remains elusive. To advance the existing knowledge in this field, we propose to investigate the polarized small-angle neutron scattering (SANS) cross section of nanocrystalline MnSi below its transition temperature. Based on micromagnetic simulations, we anticipate observing a distinct signature of skyrmions in the antisymmetric part of the polarized SANS cross section, arising from the nonzero chirality and the complex magnetic structure of skyrmions. This approach has not been previously employed to detect the diffuse scattering signal due to skyrmions in nanoparticles. Therefore, this experiment will establish polarized SANS as a unique technique to identify skyrmions in various compound forms, including single crystals, polycrystals, thin films, or nanoparticles.
DOI: 10.5286/isis.e.rb2510388
title: Characterizing lipid nanocarriers (LNCs) for targeting intracellular delivery of siRNA

description: Gene therapy by RNA interference is rapidly developing as a personal field of cancer treatment. Small interfering RNA (siRNA) plays a key role, enabling the targeting of disease-causing proteins. The successful application of siRNA relies heavily on efficient delivery systems. Lipid nanocarriers (LNCs) are used as drug delivery systems. However, tissue-specific targeting remains a key challenge to overcome. In this regard, we aim to design T7 peptide-functionalized liposomes, known for their ability to bind to the human transferrin receptor (hTfR), highly expressed on both the blood-brain barrier and blood–tumor barrier for glioma. A modified T7 peptide was synthesized and the highly selective thiol-maleimide reaction was chosen for further functionalization to DOPE-PEG2000-Mal. DOPE-PEG2000-Mal-T7 will be used as an LNCs substituent, with DPPC, DOTAP and cholesterol. By SANS measurements, exploiting the contrast-matching technique by using hydrogenated and deuterated lipids as components of the LNCs, we aim to understand where DOPE-PEG2000-Mal-T7 is located and the interaction between LNCs and hTfR.
DOI: 10.34816/ifao.archives.232951
title: SAQQARA_nb_1994_06016

description: Référence : nb_1994_06016<br />Site : Saqqara<br />Secteur : Mastaba de Ti<br />Type : photographie<br />
DOI: 10.3535/s0l-ky6-b4g
title: Succisa pratensis Moench

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/sbk-xam-2se
title: Codonorchis lessonii (d'Urv.) Lindl.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.5286/isis.e.rb2410375-1
title: Magnetic ground state of new ilmenite oxide CoIrO3 studied by muSR

description: We propose to perform muon spin relaxation experiment on a new ilmenite compound CoIrO3. Honeycomb-based iridates, ruthenium chloride, and cobaltates are recently attracting attention as a possible realization of Kitaev spin liquid. However, most candidate materials undergo magnetic ordering instead of spin-liquid state. We explored new honeycomb cobaltates by employing soft-chemical synthesis and obtained ilmenite-type CoIrO3. The compound may possess two different Kitaev honeycomb planes composed of Co2+ and Ir4+. Magnetic susceptibility of CoIrO3 shows anomalies at 115 and 80 K, but only subtle features are seen in specific heat. Therefore, the presence of magnetic order is not conclusive yet. To pin down this point, we perform ZF-muSR experiments. In addition, to study the spin dynamics, longitudinal-field measurements will be conducted. This experiment will give a clue for the potential complex magnetism of this unique Kitaev magnet.
DOI: 10.5286/isis.e.rb2420104
title: Polarized small-angle neutron scattering study of skyrmions in bulk nanocrystalline MnSi

description: It is crucial to understand the fundamental physics behind the origin and stability of skyrmions due to their potential for various quantum applications. It is also equally important to develop efficient experimental techniques to detect skyrmions in diverse material forms, such as thin films, single crystals, or nanoparticles. While attempts have been made to stabilize skyrmions in a wider temperature and magnetic field range e.g. by reducing the system dimensionality, conclusive evidence for the skyrmion phase in low-dimensional systems remains elusive. To advance the existing knowledge in this field, we propose to investigate the polarized small-angle neutron scattering (SANS) cross section of nanocrystalline MnSi below its transition temperature. Based on micromagnetic simulations, we anticipate observing a distinct signature of skyrmions in the antisymmetric part of the polarized SANS cross section, arising from the nonzero chirality and the complex magnetic structure of skyrmions. This approach has not been previously employed to detect the diffuse scattering signal due to skyrmions in nanoparticles. Therefore, this experiment will establish polarized SANS as a unique technique to identify skyrmions in various compound forms, including single crystals, polycrystals, thin films, or nanoparticles.
DOI: 10.5286/isis.e.rb2510207
title: Exploring the Magnetic Ground State of Epitaxial MnTe Films

description: We observe a previously unreported sign reversal in the anomalous Hall effect of ultra-high quality MnTe films grown on (111)A-oriented InP via molecular beam epitaxy. MnTe is a leading candidate for altermagnetism, a newly identified class of antiferromagnets with potential enormous advantages as the basis for spintronic devices. As the altermagnetic state is extremely sensitive to small perturbations in the spin structure, we seek to perform neutron diffraction above and below the sign reversal, and in a saturated magnetic state, to determine the temperature-dependent evolution of the magnetic structure.
DOI: 10.5286/isis.e.rb2510207-1
title: Exploring the Magnetic Ground State of Epitaxial MnTe Films

description: We observe a previously unreported sign reversal in the anomalous Hall effect of ultra-high quality MnTe films grown on (111)A-oriented InP via molecular beam epitaxy. MnTe is a leading candidate for altermagnetism, a newly identified class of antiferromagnets with potential enormous advantages as the basis for spintronic devices. As the altermagnetic state is extremely sensitive to small perturbations in the spin structure, we seek to perform neutron diffraction above and below the sign reversal, and in a saturated magnetic state, to determine the temperature-dependent evolution of the magnetic structure.
DOI: 10.21233/n38b80
title: Makar Inlet pollen surface sample dataset

description: Raw data for the Makar Inlet pollen surface sample dataset submitted to the Neotoma Paleoecology Database. Data is available through the landing page in JSON format. The landing page referenced by the DOI also contains links to publications and a map-based viewer for the dataset. The Neotoma Paleoecology Database maintains a homepage at https://www.neotomadb.org.
DOI: 10.34816/ifao.archives.232952
title: SAQQARA_nb_1994_06017

description: Référence : nb_1994_06017<br />Site : Saqqara<br />Secteur : Mastaba de Ti<br />Type : photographie<br />
DOI: 10.3535/c78-62j-vt6
title: Knautia arvensis (L.) Coult.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/xz9-gf7-d0b
title: Habenaria pumila Poepp.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.5286/isis.e.rb2410375
title: Magnetic ground state of new ilmenite oxide CoIrO3 studied by muSR

description: We propose to perform muon spin relaxation experiment on a new ilmenite compound CoIrO3. Honeycomb-based iridates, ruthenium chloride, and cobaltates are recently attracting attention as a possible realization of Kitaev spin liquid. However, most candidate materials undergo magnetic ordering instead of spin-liquid state. We explored new honeycomb cobaltates by employing soft-chemical synthesis and obtained ilmenite-type CoIrO3. The compound may possess two different Kitaev honeycomb planes composed of Co2+ and Ir4+. Magnetic susceptibility of CoIrO3 shows anomalies at 115 and 80 K, but only subtle features are seen in specific heat. Therefore, the presence of magnetic order is not conclusive yet. To pin down this point, we perform ZF-muSR experiments. In addition, to study the spin dynamics, longitudinal-field measurements will be conducted. This experiment will give a clue for the potential complex magnetism of this unique Kitaev magnet.
DOI: 10.5286/isis.e.rb2420108-1
title: Probing the Spin-dynamics in an Altermagnetic Candidate

description: Altermagnetism which features vanishing net magnetization and time-reversal symmetry broken electronic structures has been identified to be the third ground state of collinear magnetism. Similar to the electronic structure, the degeneracy of magnon bands with opposite chirality is predicted to be lifted. Probing the chiral splitting magnon band would be a direct experimental verification of an altermagnetic phase. MnTe with a hexagonal NiAs-type structure is an altermagnetic candidate. Previous study of MnTe has reported observation of a spontaneous anomalous Hall effect and the spin-split electronic structure revealed by angle-resolved photoemission spectroscopy. However, direct verification of altermagnetic states via neutron spectroscopic methods, e.g., measuring the chiral-split magnon bands by inelastic neutron scattering (INS), is still lacking. Therefore, INS data is imperatively needed.
DOI: 10.3535/l34-nvq-6c4
title: Weigela florida (Bunge) A. DC.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.5286/isis.e.rb2420108
title: Probing the Spin-dynamics in an Altermagnetic Candidate

description: Altermagnetism which features vanishing net magnetization and time-reversal symmetry broken electronic structures has been identified to be the third ground state of collinear magnetism. Similar to the electronic structure, the degeneracy of magnon bands with opposite chirality is predicted to be lifted. Probing the chiral splitting magnon band would be a direct experimental verification of an altermagnetic phase. MnTe with a hexagonal NiAs-type structure is an altermagnetic candidate. Previous study of MnTe has reported observation of a spontaneous anomalous Hall effect and the spin-split electronic structure revealed by angle-resolved photoemission spectroscopy. However, direct verification of altermagnetic states via neutron spectroscopic methods, e.g., measuring the chiral-split magnon bands by inelastic neutron scattering (INS), is still lacking. Therefore, INS data is imperatively needed.
DOI: 10.5286/isis.e.rb2510644
title: Characterization of Antimicrobial Peptide Distribution and Nano-Scale Structures in HEC Hydrogels using SANS

description: Studying the structural mechanisms of antimicrobial peptides (AMPs) in enhancing the mechanical properties of hydrogels is essential for developing effective drug delivery systems. Hydroxyethyl cellulose (HEC)-based hydrogels are promising in biomedical applications due to their biocompatibility, water retention, and tunable mechanical properties. A significant focus is on the encapsulation and controlled release of AMPs, crucial for combating drug-resistant bacteria in applications like wound dressings. However, challenges persist in ensuring peptide stability and controlled release. Small-angle neutron scattering (SANS) offers a powerful, non-destructive method to investigate the internal nanostructure of hydrogels, providing insights into the spatial distribution of embedded molecules like AMPs. This study aims to utilize SANS to explore how the structural organization of HEC hydrogels influences AMP distribution and release profiles, ultimately affecting their therapeutic efficacy in drug delivery.
DOI: 10.5286/isis.e.rb2510644-1
title: Characterization of Antimicrobial Peptide Distribution and Nano-Scale Structures in HEC Hydrogels using SANS

description: Studying the structural mechanisms of antimicrobial peptides (AMPs) in enhancing the mechanical properties of hydrogels is essential for developing effective drug delivery systems. Hydroxyethyl cellulose (HEC)-based hydrogels are promising in biomedical applications due to their biocompatibility, water retention, and tunable mechanical properties. A significant focus is on the encapsulation and controlled release of AMPs, crucial for combating drug-resistant bacteria in applications like wound dressings. However, challenges persist in ensuring peptide stability and controlled release. Small-angle neutron scattering (SANS) offers a powerful, non-destructive method to investigate the internal nanostructure of hydrogels, providing insights into the spatial distribution of embedded molecules like AMPs. This study aims to utilize SANS to explore how the structural organization of HEC hydrogels influences AMP distribution and release profiles, ultimately affecting their therapeutic efficacy in drug delivery.
DOI: 10.34816/ifao.archives.232953
title: SAQQARA_nb_1994_06018

description: Référence : nb_1994_06018<br />Site : Saqqara<br />Secteur : Mastaba de Ti<br />Type : photographie<br />
DOI: 10.3535/lz1-2c8-3y2
title: Alstroemeria aurea Graham

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/zzw-nms-4w2
title: Lonicera tatarica L.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.5286/isis.e.rb2420306-1
title: Polymer interactions with phospholipid monolayers: Understanding formation of polymer-stabilized nanodiscs

description: Polymer stabilized phospholipid nanodiscs are gaining rapid interest as a detergent free method of extracting membrane proteins from cell membranes and maintaining them in an active state in solution. Although the structure of the discs is established, with the polymer belt wrapping the exposed hydrophobic tails of a ~10nm disc of lipid bilayer, it is not known how this structure forms from the initially intact lipid membrane. Formation speed of the discs depends on monolayer composition but so far our, and similar studies by others have used largely simple phospholipid layers. In this experiment we aim to use the new higher flux on INTER to follow the kinetics of adsorption and/or penetration of polymer to more complex lipid monolayers at the air water interface containing unsaturated and saturated lipids, as well as to characterise the evolving structure of the lipid/polymer layer. We will vary the surface pressure and composition of the lipid membrane to investigate the effects of fluidity and phase separation, and the polymer type and hydrophobic/hydrophilic balance. These experiments will access timescales inaccessible on other neutron reflectometers, to improve our understanding of how polymer-stabilized nanodiscs form, which will improve their future application and uptake in membrane protein biology.
DOI: 10.5286/isis.e.rb2510542
title: Estimating residual stress levels in inertia friction welded Ni-based superalloy assemblies for enhanced production process modelling

description: Determining residual stresses in welds is fundamental in ensuring long-term resilience of safety critical joints. Inertia friction welds experience severe localised thermo-mechanical states, posing a specific set of challenges that complicate post weld state prediction. While the evolution of material structure under such aggressive conditions has received a great deal of attention, detailed analysis of residual stresses (particularly in industry relevant components) is lacking. Specific machine characteristics (tooling compliance, for example), initial component geometry, and alignment are suspected to be highly influential in developing non-axisymmetric residual stresses. The proposed project will support a comprehensive holistic analysis of an inertia friction welding relevant assembly. Coordinate-measuring machine readings have been recorded for a collection of components pre and post weld, allowing for a precise tracking of geometry. These results, along with a detailed machine and material model, will allow for advanced predictions of the inertia friction welding process and the enhanced estimation of post weld condition. Residual stress measurements gathered at ISIS Engin-X in this project will provide vital validation for this modelling exercise, enabling improved industry relevant understanding of the process and refinement of key processing variables.
DOI: 10.5286/isis.e.rb2510542-1
title: Estimating residual stress levels in inertia friction welded Ni-based superalloy assemblies for enhanced production process modelling

description: Determining residual stresses in welds is fundamental in ensuring long-term resilience of safety critical joints. Inertia friction welds experience severe localised thermo-mechanical states, posing a specific set of challenges that complicate post weld state prediction. While the evolution of material structure under such aggressive conditions has received a great deal of attention, detailed analysis of residual stresses (particularly in industry relevant components) is lacking. Specific machine characteristics (tooling compliance, for example), initial component geometry, and alignment are suspected to be highly influential in developing non-axisymmetric residual stresses. The proposed project will support a comprehensive holistic analysis of an inertia friction welding relevant assembly. Coordinate-measuring machine readings have been recorded for a collection of components pre and post weld, allowing for a precise tracking of geometry. These results, along with a detailed machine and material model, will allow for advanced predictions of the inertia friction welding process and the enhanced estimation of post weld condition. Residual stress measurements gathered at ISIS Engin-X in this project will provide vital validation for this modelling exercise, enabling improved industry relevant understanding of the process and refinement of key processing variables.
DOI: 10.3535/2vm-kq0-d0x
title: Azara lanceolata Hook. fil.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/v59-ft3-zjn
title: Lonicera caprifolium L.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.5286/isis.e.rb1970123-1
title: muSR study of charge carrier dynamics in active layer of hybrid solar cells

description: Recently, hybrid solar cell has been developed owing to the combined advantage between organic material P3HT and inorganic material ZnO. We have studied the microscopic intrinsic charge carrier dynamics in active material of P3HT:ZnO and P3HT:ZnO:PCBM along and perpendicular to the chain by using LF muSR. We found that the charge carrier mobility changes from intra-chain to inter-chain diffusion both above 25 K. We have also measured charge carrier dynamics of P3HT:ZnO with light irradiation. We found small changes of asymmetry when light irradiation on and off, however we cannot observe significant effect due to low intensity of light irradiation. Here, we propose to study the effect of high intensity light irradiation to elucidate the intra- and inter-chain charge carrier dynamics in P3HT:ZnO and P3HT:ZnO:PCBM by using LF muSR at various temperature down to 10 K from 0 to 3950 G.
DOI: 10.5286/isis.e.rb2420306
title: Polymer interactions with phospholipid monolayers: Understanding formation of polymer-stabilized nanodiscs

description: Polymer stabilized phospholipid nanodiscs are gaining rapid interest as a detergent free method of extracting membrane proteins from cell membranes and maintaining them in an active state in solution. Although the structure of the discs is established, with the polymer belt wrapping the exposed hydrophobic tails of a ~10nm disc of lipid bilayer, it is not known how this structure forms from the initially intact lipid membrane. Formation speed of the discs depends on monolayer composition but so far our, and similar studies by others have used largely simple phospholipid layers. In this experiment we aim to use the new higher flux on INTER to follow the kinetics of adsorption and/or penetration of polymer to more complex lipid monolayers at the air water interface containing unsaturated and saturated lipids, as well as to characterise the evolving structure of the lipid/polymer layer. We will vary the surface pressure and composition of the lipid membrane to investigate the effects of fluidity and phase separation, and the polymer type and hydrophobic/hydrophilic balance. These experiments will access timescales inaccessible on other neutron reflectometers, to improve our understanding of how polymer-stabilized nanodiscs form, which will improve their future application and uptake in membrane protein biology.
DOI: 10.5286/isis.e.rb2590018-1
title: Is Li+ mobile within the Li2Mn(C2O4)2 oxalate Li-ion battery cathode?
DOI: 10.34740/kaggle/dsv/12417065
title: Peer-to-Peer Boliviano (BOB) Exchange Data
DOI: 10.34816/ifao.archives.232954
title: SAQQARA_nb_1994_06019

description: Référence : nb_1994_06019<br />Site : Saqqara<br />Secteur : Mastaba de Ti<br />Type : photographie<br />
DOI: 10.3535/nw0-khv-yy5
title: Quinchamalium chilense Molina

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/z59-e66-nef
title: Ovidia pillo-pillo (Gay) Hohen. ex Meisn.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.