cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.29957627.v1
title: Supplementary Material for: FBXW7 Protects Against Diabetic Nephropathy by Targeting Metadherin For Ubiquitin Degradation

description: Objective: Diabetic nephropathy (DN), a critical complication of diabetes, is characterized by progressive renal function impairment and fibrosis development. F-box and WD repeat domain-containing 7 (FBXW7), an E3 ubiquitin ligase, is recognized for its role in metabolic disorders, however, its specific functions and mechanisms in DN remain incompletely understood. This study aimed to clarify the role of FBXW7 in the pathogenesis of DN.
Methods: Mouse tubular epithelial cells (mTECs) cultured under hyperglycemic conditions were used. FBXW7 overexpression was induced in the kidneys of db/db mice and in mTECs to evaluate its effects on renal fibrosis and related molecular pathways. The interaction between FBXW7 and metadherin (Mtdh) was examined by using co-immunoprecipitation (Co-IP) and western blotting techniques.
Results: FBXW7 expression was found to be significant reduced in in the kidneys of DN patients and db/db mice. Overexpression of FBXW7 markedly improved albuminuria, blood urea nitrogen, uric acid levels, and renal fibrosis in db/db mice. Additionally, FBXW7 was shown to inhibit high glucose-induced fibrosis in mTECs through a mechanism involving the ubiquitin-mediated degradation of Mtdh, a protein known to promote fibrosis. Suppression of Mtdh via FBXW7 overexpression was also linked to inactivation of TGF-β/Smad3 signaling in DN.
Conclusion: These findings highlight the protective role of FBXW7 in DN by downregulating Mtdh and indicate that FBXW7 represents a promising therapeutic target for DN.
Key words: Diabetic nephropathy, FBXW7, metadherin, ubiquitin
DOI: 10.6084/m9.figshare.29957630
title: Supplementary Material for: Physicians' and Pharmacists' Knowledge, Thoughts, and Attitudes of Homeopathy: A Comparative Survey in Türkiye

description: Background Homeopathy, included in traditional and complementary medicine (TCM), is defined as a complementary treatment that aims to improve health through personalized therapy. Physicians and pharmacists play a crucial role in the practice of homeopathy and the delivery of homeopathic medicinal products to the public in Türkiye. This study aims to evaluate the knowledge, thoughts, and attitudes of physicians and pharmacists on homeopathy in accordance with Turkish regulations.
Methods This descriptive study was carried out on physicians and pharmacists via a web-based questionnaire method. The survey form includes three sections and twenty-three questions. Participants received the survey form via Facebook, Instagram, X (Twitter), and LinkedIn. A total of 475 questionnaires that met the data quality criteria were included in the study. The analysis of the data was performed with the SPSS 23.0 statistical program, with a statistical significance level set at p &lt; 0.05.
Results The study population included 70.3% (n = 334) pharmacists and 29.7% (n = 141) physicians. The study's results demonstrate that 86.5% of participants had heard of the concept of homeopathy. It was found that a higher rate of hearing of homeopathy was associated with being a pharmacist (OR: 31.5, p = 0.000) and having ten years or more of professional experience (OR: 7.274, p = 0.000). The participants had correct knowledge about the definition and basic principles of homeopathy. The respondents lacked knowledge on certain aspects of the regulation of homeopathic practice in Türkiye. The primary source of information for pharmacists was undergraduate courses (n = 185, 58.2%), but for physicians, it was social media/television (n = 41, 50.0%). 70.1% (n = 288) thought that homeopathy needs to be incorporated into the undergraduate curriculum. 91.7% of participants thought that further scientific research on homeopathy is required.
Conclusion Homeopathy courses should be integrated into undergraduate education to improve the awareness of healthcare professionals. Further, the organization of seminars and training courses would enhance their knowledge of the relevant subject.
DOI: 10.5281/zenodo.16917811
title: Polyoxometalate Imide-Linked Molecules, Covalent Organic Polymers, and Frameworks: Dimensionality Effects on Supercapacitors Performance

description: Efficient and durable energy storage materials are essential to meet the increasing demand for renewable energy technologies. However, existing materials often encounter trade-offs among energy density, power density, and cycling stability. To overcome these limitations, a 2D imide-linked polyoxometalate-covalent organic framework (i-POCOF) is introduced. This hybrid material combines the redox activity of polyoxometalates (POMs) with the structural adaptability of covalent organic frameworks (COFs). Complementarily, 0D imide-functionalized POM-molecule and 1D POM-polymer systems are investigated, enabling a systematic evaluation of how dimensionality affects their physicochemical properties and electrochemical performance. By increasing dimensionality, the hybrids exhibit improved surface area ranging from 107 m2 g−1 for 0D to 257 m2 g−1 for 2D, and optimized porosity (average pore size from 1.9 nm for 0D to 3.7 nm for 2D), resulting in enhanced ion diffusion and charge transport. In particular, 2D i-POCOF exhibits remarkable electrochemical performance, achieving a specific capacitance of 132 F g−1, energy density of 73.3 Wh kg−1, and power density of 0.9 kW kg−1, with only 6% capacitance loss after 5000 cycles. These findings highlight the potential of POM hybrids as high-performance and stable energy storage hybrids, providing a promising pathway to overcome current limitations in electrode materials.
description: This work was supported by the National Science Centre, Poland (grant no. 2022/47/D/ST5/00261; 2020/39/D/ST4/01182 and 2022/45/N/ST4/00632). Daria Nowicka is a scholarship holder of the Adam Mickiewicz University in Poznan Foundation for the academic year 2023/2024.
DOI: 10.5281/zenodo.16917812
title: Polyoxometalate Imide-Linked Molecules, Covalent Organic Polymers, and Frameworks: Dimensionality Effects on Supercapacitors Performance

description: Efficient and durable energy storage materials are essential to meet the increasing demand for renewable energy technologies. However, existing materials often encounter trade-offs among energy density, power density, and cycling stability. To overcome these limitations, a 2D imide-linked polyoxometalate-covalent organic framework (i-POCOF) is introduced. This hybrid material combines the redox activity of polyoxometalates (POMs) with the structural adaptability of covalent organic frameworks (COFs). Complementarily, 0D imide-functionalized POM-molecule and 1D POM-polymer systems are investigated, enabling a systematic evaluation of how dimensionality affects their physicochemical properties and electrochemical performance. By increasing dimensionality, the hybrids exhibit improved surface area ranging from 107 m2 g−1 for 0D to 257 m2 g−1 for 2D, and optimized porosity (average pore size from 1.9 nm for 0D to 3.7 nm for 2D), resulting in enhanced ion diffusion and charge transport. In particular, 2D i-POCOF exhibits remarkable electrochemical performance, achieving a specific capacitance of 132 F g−1, energy density of 73.3 Wh kg−1, and power density of 0.9 kW kg−1, with only 6% capacitance loss after 5000 cycles. These findings highlight the potential of POM hybrids as high-performance and stable energy storage hybrids, providing a promising pathway to overcome current limitations in electrode materials.
description: This work was supported by the National Science Centre, Poland (grant no. 2022/47/D/ST5/00261; 2020/39/D/ST4/01182 and 2022/45/N/ST4/00632). Daria Nowicka is a scholarship holder of the Adam Mickiewicz University in Poznan Foundation for the academic year 2023/2024.
DOI: 10.6084/m9.figshare.29957630.v1
title: Supplementary Material for: Physicians' and Pharmacists' Knowledge, Thoughts, and Attitudes of Homeopathy: A Comparative Survey in Türkiye

description: Background Homeopathy, included in traditional and complementary medicine (TCM), is defined as a complementary treatment that aims to improve health through personalized therapy. Physicians and pharmacists play a crucial role in the practice of homeopathy and the delivery of homeopathic medicinal products to the public in Türkiye. This study aims to evaluate the knowledge, thoughts, and attitudes of physicians and pharmacists on homeopathy in accordance with Turkish regulations.
Methods This descriptive study was carried out on physicians and pharmacists via a web-based questionnaire method. The survey form includes three sections and twenty-three questions. Participants received the survey form via Facebook, Instagram, X (Twitter), and LinkedIn. A total of 475 questionnaires that met the data quality criteria were included in the study. The analysis of the data was performed with the SPSS 23.0 statistical program, with a statistical significance level set at p &lt; 0.05.
Results The study population included 70.3% (n = 334) pharmacists and 29.7% (n = 141) physicians. The study's results demonstrate that 86.5% of participants had heard of the concept of homeopathy. It was found that a higher rate of hearing of homeopathy was associated with being a pharmacist (OR: 31.5, p = 0.000) and having ten years or more of professional experience (OR: 7.274, p = 0.000). The participants had correct knowledge about the definition and basic principles of homeopathy. The respondents lacked knowledge on certain aspects of the regulation of homeopathic practice in Türkiye. The primary source of information for pharmacists was undergraduate courses (n = 185, 58.2%), but for physicians, it was social media/television (n = 41, 50.0%). 70.1% (n = 288) thought that homeopathy needs to be incorporated into the undergraduate curriculum. 91.7% of participants thought that further scientific research on homeopathy is required.
Conclusion Homeopathy courses should be integrated into undergraduate education to improve the awareness of healthcare professionals. Further, the organization of seminars and training courses would enhance their knowledge of the relevant subject.
DOI: 10.6084/m9.figshare.29957633
title: Supplementary Material for: Prevalence of Alloimmunization and Associated Risk Factors Among Antenatal Women in India: A Systematic Review and Meta-Analysis

description: Background
Maternal alloimmunization can lead to significant perinatal morbidity and mortality. The rate of maternal alloimmunization reported is varied across the studies conducted in India. A systematic review will help in understanding the overall prevalence of alloimmunization. Additionally, the study aimed at understanding the factors affecting the rate of maternal alloimmunization. 
Methods
A search of original articles reporting rate of alloimmunization among antenatal women published in English language from India was performed in SCOPUS, GOOGLE SCHOLAR, MEDLINE, CINAHL databases. Two independent teams, each comprising two reviewers, extracted data from the eligible studies. Meta-analysis was performed for cumulative estimates by binary random effects model using the restricted maximum likelihood method.
Results
Fourteen studies published between 2011 and 2023 were included. The pooled prevalence of maternal alloimmunization was 2.0 per 100 (95% CI: 1.5–2.5) among antenatal women, with significant heterogeneity across studies. Anti-D was the most frequently identified antibody (56.39%), followed by anti-D + anti-C (10.68%) and anti-E (5.71%). Higher odds of alloimmunization were observed in women with RhD-negative blood group, multigravida status, history of blood transfusion, and bad obstetric history.
Conclusion
Despite the availability of anti-D prophylaxis, over half of the alloimmunized women developed anti-D antibodies, indicating potential gaps in prevention strategies. Further research is needed to understand these gaps and implement effective interventions to minimize this preventable cause of fetal and neonatal complications. Prophylactic antigen-matched (Rh and Kell) red cell transfusion in girls and women of reproductive age may reduce the burden of alloimmunization.
DOI: 10.6084/m9.figshare.29957633.v1
title: Supplementary Material for: Prevalence of Alloimmunization and Associated Risk Factors Among Antenatal Women in India: A Systematic Review and Meta-Analysis

description: Background
Maternal alloimmunization can lead to significant perinatal morbidity and mortality. The rate of maternal alloimmunization reported is varied across the studies conducted in India. A systematic review will help in understanding the overall prevalence of alloimmunization. Additionally, the study aimed at understanding the factors affecting the rate of maternal alloimmunization. 
Methods
A search of original articles reporting rate of alloimmunization among antenatal women published in English language from India was performed in SCOPUS, GOOGLE SCHOLAR, MEDLINE, CINAHL databases. Two independent teams, each comprising two reviewers, extracted data from the eligible studies. Meta-analysis was performed for cumulative estimates by binary random effects model using the restricted maximum likelihood method.
Results
Fourteen studies published between 2011 and 2023 were included. The pooled prevalence of maternal alloimmunization was 2.0 per 100 (95% CI: 1.5–2.5) among antenatal women, with significant heterogeneity across studies. Anti-D was the most frequently identified antibody (56.39%), followed by anti-D + anti-C (10.68%) and anti-E (5.71%). Higher odds of alloimmunization were observed in women with RhD-negative blood group, multigravida status, history of blood transfusion, and bad obstetric history.
Conclusion
Despite the availability of anti-D prophylaxis, over half of the alloimmunized women developed anti-D antibodies, indicating potential gaps in prevention strategies. Further research is needed to understand these gaps and implement effective interventions to minimize this preventable cause of fetal and neonatal complications. Prophylactic antigen-matched (Rh and Kell) red cell transfusion in girls and women of reproductive age may reduce the burden of alloimmunization.
DOI: 10.6084/m9.figshare.29957636
title: Supplementary Material for: Apolipoprotein E, Executive Function, and Falls Across Cognitive Status: A Cross-Sectional Study

description: Introduction: Falls are a critical public health issue, with executive function (EF) impairment being a contributing factor. However, whether Apolipoprotein E4 (ApoE4) influences the relationship between EF and falls is unclear. This study investigated the potential moderating effect of ApoE4 on the EF and falls relationship in older adults with unimpaired cognition, mild cognitive impairment (MCI), and Alzheimer’s disease (AD) dementia. Methods: Analyzed cross-sectional data from 486 participants in the Brain and Body Donation Program of the Arizona Study of Aging and Neurodegenerative Disorders database. EF was assessed through a composite latent variable using the Trail Making Test, Stroop Interference, Digit Span, Clock Drawing test, and verbal fluency tests. ApoE genotypes were categorized as carriers and non-carriers of ApoE4. Logistic regression was used with fall history and a future fall as outcomes. Results: ApoE4 did not moderate the EF and falls relationship (p≥0.05). A significant interaction effect revealed that EF is associated with fall history for individuals with unimpaired cognition and MCI but not with AD dementia (OR=1.658, p=0.032). Significantly associated covariates with fall history included elements from the Unified Parkinson’s Disease Rating Scale, medical conditions, and depression (p&lt;0.05), while medical conditions and fall history were significantly associated with future falls (p&lt;0.05). Conclusion: ApoE4 did not significantly moderate the relationship between EF and Falls. However, EF’s impact on falls varied by cognitive status.
DOI: 10.6084/m9.figshare.29957636.v1
title: Supplementary Material for: Apolipoprotein E, Executive Function, and Falls Across Cognitive Status: A Cross-Sectional Study

description: Introduction: Falls are a critical public health issue, with executive function (EF) impairment being a contributing factor. However, whether Apolipoprotein E4 (ApoE4) influences the relationship between EF and falls is unclear. This study investigated the potential moderating effect of ApoE4 on the EF and falls relationship in older adults with unimpaired cognition, mild cognitive impairment (MCI), and Alzheimer’s disease (AD) dementia. Methods: Analyzed cross-sectional data from 486 participants in the Brain and Body Donation Program of the Arizona Study of Aging and Neurodegenerative Disorders database. EF was assessed through a composite latent variable using the Trail Making Test, Stroop Interference, Digit Span, Clock Drawing test, and verbal fluency tests. ApoE genotypes were categorized as carriers and non-carriers of ApoE4. Logistic regression was used with fall history and a future fall as outcomes. Results: ApoE4 did not moderate the EF and falls relationship (p≥0.05). A significant interaction effect revealed that EF is associated with fall history for individuals with unimpaired cognition and MCI but not with AD dementia (OR=1.658, p=0.032). Significantly associated covariates with fall history included elements from the Unified Parkinson’s Disease Rating Scale, medical conditions, and depression (p&lt;0.05), while medical conditions and fall history were significantly associated with future falls (p&lt;0.05). Conclusion: ApoE4 did not significantly moderate the relationship between EF and Falls. However, EF’s impact on falls varied by cognitive status.
DOI: 10.6084/m9.figshare.29957639
title: Supplementary Material for: Economic Evaluations of Preventive & Minimally Invasive Children's Dental Caries Procedures: A Scoping Review

description: Introduction: The WHO’s Global Oral Health Action Plan towards 2030 suggests prioritizing cost-effective preventive and minimally invasive (MI) dental caries interventions as essential oral health care services. Given the high prevalence of dental caries among children, raising awareness of the limitations and research gaps of the existing economic evaluations assessing preventive and MI procedures is crucial. Objective: This scoping review aimed to identify and map the relevant literature on economic evaluations for preventive and MI dental caries procedures among children under 12 years of age. Methods: We conducted a systematic literature search using Medline, EMBASE, Scopus, Web of Science, Cochrane, LILACS, and PEDE up to December 31st, 2023. Two independent reviewers performed the screening and data extraction using the Covidence software. A third reviewer resolved disagreements. Inclusion criteria comprised full economic evaluations, and full-text original articles published in peer-reviewed journals, in English, Spanish, or Portuguese, without any date restrictions. Data extraction included methodological characteristics items. We appraised the content reported using the Consolidated Health Economic Evaluation Reporting Standards (CHEERS) 2022 checklist. Results: Among 1285 studies screened, 62 were selected for data extraction. Most studies conducted a cost-eﬀectiveness analysis (98%, n=61), and only 10% (n=6) and 3% (n=2) conducted a cost-benefit and cost-utility analysis, respectively. The majority of studies evaluated sealants (32%, n=20) and fluoride varnish (24%, n=15), and only three assessed the cost-effectiveness of silver diamine fluoride. None of the included studies reported the CHEERS item related to community engagement. Moreover, there is a lack of studies among populations from the African region, most low- and lower-middle-income countries, and Indigenous communities. Conclusion: Economic evaluations of preventive and MI dental caries procedures among children have increased over the last decade. Nonetheless, these are mostly cost-effectiveness analyses using clinically oriented outcomes, as opposed to patient-centred outcomes. We recommend collaboration with community partners while conducting economic evaluations for mutual capacity building.
DOI: 10.6084/m9.figshare.29957639.v1
title: Supplementary Material for: Economic Evaluations of Preventive & Minimally Invasive Children's Dental Caries Procedures: A Scoping Review

description: Introduction: The WHO’s Global Oral Health Action Plan towards 2030 suggests prioritizing cost-effective preventive and minimally invasive (MI) dental caries interventions as essential oral health care services. Given the high prevalence of dental caries among children, raising awareness of the limitations and research gaps of the existing economic evaluations assessing preventive and MI procedures is crucial. Objective: This scoping review aimed to identify and map the relevant literature on economic evaluations for preventive and MI dental caries procedures among children under 12 years of age. Methods: We conducted a systematic literature search using Medline, EMBASE, Scopus, Web of Science, Cochrane, LILACS, and PEDE up to December 31st, 2023. Two independent reviewers performed the screening and data extraction using the Covidence software. A third reviewer resolved disagreements. Inclusion criteria comprised full economic evaluations, and full-text original articles published in peer-reviewed journals, in English, Spanish, or Portuguese, without any date restrictions. Data extraction included methodological characteristics items. We appraised the content reported using the Consolidated Health Economic Evaluation Reporting Standards (CHEERS) 2022 checklist. Results: Among 1285 studies screened, 62 were selected for data extraction. Most studies conducted a cost-eﬀectiveness analysis (98%, n=61), and only 10% (n=6) and 3% (n=2) conducted a cost-benefit and cost-utility analysis, respectively. The majority of studies evaluated sealants (32%, n=20) and fluoride varnish (24%, n=15), and only three assessed the cost-effectiveness of silver diamine fluoride. None of the included studies reported the CHEERS item related to community engagement. Moreover, there is a lack of studies among populations from the African region, most low- and lower-middle-income countries, and Indigenous communities. Conclusion: Economic evaluations of preventive and MI dental caries procedures among children have increased over the last decade. Nonetheless, these are mostly cost-effectiveness analyses using clinically oriented outcomes, as opposed to patient-centred outcomes. We recommend collaboration with community partners while conducting economic evaluations for mutual capacity building.