cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.9927236
title: THERMOPHILIC BIOMETHANE PRODUCTION BY VINASSE IN AN AnSBBR: START-UP STRATEGY AND PERFORMANCE OPTIMIZATION

description: Abstract Thermophilic anaerobic digestion treatment of industrial wastewater generated at high temperatures can be used as an alternative for environmental pollution control and bioenergy production. Therefore, this study investigated thermophilic anaerobic reactors containing immobilized biomass (AnSBBR) to treat vinasse for methane production, in batch and fed-batch mode, in a three-step approach. In Step I (batch), the biomass was properly adapted to the thermophilic condition (55 °C) with a feed containing vinasse plus molasses as a co-substrate. In Step II (batch), the applied volumetric organic load (AVOL) was increased and resulted in a methane molar productivity of 304 molCH4.m-3.d-1 at an AVOL of 25.9 gCOD.L-1.d-1 and a yield of methane per removed organic matter near 331 NmL-CH4.gCOD-1. In Step III, a fed-batch strategy was employed at an AVOL of 25.1 gCOD.L-1.d-1 and achieved an optimum methane productivity of 352 molCH4.m-3.d-1 with COD and carbohydrate removal efficiencies of approximately 80 % and 90%, respectively. A kinetic model fitted to the experimental data allowed better understanding of the anaerobic metabolic reactions. Finally, the results obtained demonstrated that a thermophilic AnSBBR is an efficient technological alternative for methane production through vinasse digestion.
DOI: 10.6084/m9.figshare.9927254.v1
title: Burden, depression and anxiety in primary caregivers of children and adolescents in renal replacement therapy

description: ABSTRACT Introduction: Chronic kidney disease (CKD) is rare in children, but it causes repercussions in several aspects of life, because the disease and treatment cause great changes in the daily lives of the child and his family, increasing the burden on caregivers. Objective: To evaluate the burden of primary caregivers of children and adolescents who undergo renal replacement therapy (RRT). Methods: Cross-sectional, observational study performed at the Pediatric Renal Unit of a school hospital in the Northeast. Forty-nine primary caregivers of pediatric patients with CKD in RRT followed up in our clinic participated in the study. We used validated instruments to assess burden, depression and anxiety. We ran some tests to analyze the findings of burden, depression and anxiety in the sample. Results: Most of the caregivers are the mothers of these children (89.8%), aged between 36 and 45 years (46.9%), have Elementary School education only (55.1%) and reported feeling pain in the body (69.4%), but they did not have chronic disease. The majority of the children have been in RRT from 1 to 3 years (40.8%), aged from 9 to 11 years (30.6%), are male (55.1%), and under hemodialysis (38.8%). The caregivers had a moderate level of burden (2.10), a high prevalence of moderate to severe depression (18.4%) and anxiety (47%), and a strong correlation between burden, depression and anxiety. Conclusions: Caring for a child with CKD is an intense experience, with negative consequences, due to uncertainties about the future and the very care these children require. We need to do something to help these caregivers better manage care, as well as cope with their own feelings.
DOI: 10.6084/m9.figshare.9927245.v1
title: Descriptive analysis of spending on hospitalizations due to ambulatory care sensitive conditions

description: Abstract Background Funding is a problem present throughout the history of the Brazilian Unified Health System (SUS). Health spending in Brazil have always been insufficient to ensure the principles of SUS. Objective To analyze spending on hospitalizations due to ambulatory care for sensitive conditions (HACSC) and their impact on health expenditures. Method This study analyzed spending on health in São Leopoldo, RS, between 2003 and 2012. It is an ecological study using data available from the Informatics Department of Brazil’s National Unified Health System through the Hospital Information System and the Information System of Public Health Budget. Results São Leopoldo’s total health expenditure increased 70.91% in the period, growing 58.52% in per capita spending, and only 21.75% in expenses for primary health care (PHC). Spending on HACSC increased 16.30% and total spending with hospitalization decreased 3.54%. Compared to total health expenditure, the spending on HACSC represented 2.57%, in 2003, and 1.75%, in 2012. Comparing to expenses for PHC, the average spending on HACSC represented 19.43% of expenses on PHC. Conclusion There was an increase in per capita spending on health, but still insufficient. The amounts spent on the ICSAP could represent a significant savings to the health system.
DOI: 10.6084/m9.figshare.9927230
title: Artifacts of the school material culture in Rio Grande do Sul: a study of Cartilha Mestra and Cartilha Samorim

description: ABSTRACT Considering textbooks - specifically primers - as a constitutive and important part of the school material culture, this study aims to present a comparative analysis of Cartilha Mestra and Cartilha Samorim- both of which were written by southern Brazilian professor Samorim Gustavo de Andrade - using the 12th edition of the former, from 1919/1913, and the first edition of the latter, from 1921. Produced in a context of consolidation of the positivist government in the state of Rio Grande do Sul, of the constitution of the public education system, and of the growth of a “school industry”, such primers were widely used in southern Brazilian schools and expressed part of the school material culture of that time. In this article, the two above-mentioned samples were compared having the book as a study object from the perspective of their publishing history and the school material culture. The study found that Cartilha Samorim is an enlarged version of Cartilha Mestra. However, each edition brings particularities, such as the addition of cursive handwriting and texts for the development of reading fluency in the 1921’s version. The observed changes were most likely articulated to the discourse of the time with respect to the approaches for the teaching of reading and writing and to social and pedagogical demands.
DOI: 10.6084/m9.figshare.9927236.v1
title: THERMOPHILIC BIOMETHANE PRODUCTION BY VINASSE IN AN AnSBBR: START-UP STRATEGY AND PERFORMANCE OPTIMIZATION

description: Abstract Thermophilic anaerobic digestion treatment of industrial wastewater generated at high temperatures can be used as an alternative for environmental pollution control and bioenergy production. Therefore, this study investigated thermophilic anaerobic reactors containing immobilized biomass (AnSBBR) to treat vinasse for methane production, in batch and fed-batch mode, in a three-step approach. In Step I (batch), the biomass was properly adapted to the thermophilic condition (55 °C) with a feed containing vinasse plus molasses as a co-substrate. In Step II (batch), the applied volumetric organic load (AVOL) was increased and resulted in a methane molar productivity of 304 molCH4.m-3.d-1 at an AVOL of 25.9 gCOD.L-1.d-1 and a yield of methane per removed organic matter near 331 NmL-CH4.gCOD-1. In Step III, a fed-batch strategy was employed at an AVOL of 25.1 gCOD.L-1.d-1 and achieved an optimum methane productivity of 352 molCH4.m-3.d-1 with COD and carbohydrate removal efficiencies of approximately 80 % and 90%, respectively. A kinetic model fitted to the experimental data allowed better understanding of the anaerobic metabolic reactions. Finally, the results obtained demonstrated that a thermophilic AnSBBR is an efficient technological alternative for methane production through vinasse digestion.
DOI: 10.6084/m9.figshare.9927224
title: Quality of Life Assessment by the Endometriosis Health Profile (EHP-30) Questionnaire Prior to Treatment for Ovarian Endometriosis in Brazilian Women

description: Abstract Objective To evaluate the existence of an association between ultrasound findings and epidemiological and clinical factors using results obtained from the EHP-30 questionnaire in women with ovarian endometriosis. Methods A cross-sectional observational study was performed between July 2012 and May 2015, in which patients with chronic pelvic pain suggestive of endometrioma, as indicated by the results from a transvaginal pelvic ultrasonography, completed the standardized Endometriosis Health Profile - 30 (EHP-30) questionnaire to access quality-of-life scores before beginning treatment for endometriosis. A total of 65 patients were included. The data was analyzed in the statistical program IBM SPSS Statistics for Windows, Version 22.0 (IBM Corp., Armonk, NY, USA) for the comparison of data through linear multiple regression. Results The suitability of the linear regression model was confirmed by the histogram of the dependent variable and the residue distribution plot, confirming the trend of linearity as well as the homogeneous dispersion of the residues. The mean age of the patients was 39.7 ± 7.1 years old. Themajority was Caucasian (64.5%), had completed higher education (56.5%) and was nulligravida (40.3%). Infertility was present in 48.4% of the patients studied. Out of the total sample, 80.6% of the cases were symptomatic and complained mainly of acyclic pain, 79% of dysmenorrhea, and 61.3% of dyspareunia. This reflects the negative influence of endometriosis on the quality of life of patients with this disease. Conclusion Dyspareunia and acyclic pain were independent factors of correlation with high scores in the EHP-30 questionnaire, reflecting a worse quality of life.
DOI: 10.6084/m9.figshare.9927230.v1
title: Artifacts of the school material culture in Rio Grande do Sul: a study of Cartilha Mestra and Cartilha Samorim

description: ABSTRACT Considering textbooks - specifically primers - as a constitutive and important part of the school material culture, this study aims to present a comparative analysis of Cartilha Mestra and Cartilha Samorim- both of which were written by southern Brazilian professor Samorim Gustavo de Andrade - using the 12th edition of the former, from 1919/1913, and the first edition of the latter, from 1921. Produced in a context of consolidation of the positivist government in the state of Rio Grande do Sul, of the constitution of the public education system, and of the growth of a “school industry”, such primers were widely used in southern Brazilian schools and expressed part of the school material culture of that time. In this article, the two above-mentioned samples were compared having the book as a study object from the perspective of their publishing history and the school material culture. The study found that Cartilha Samorim is an enlarged version of Cartilha Mestra. However, each edition brings particularities, such as the addition of cursive handwriting and texts for the development of reading fluency in the 1921’s version. The observed changes were most likely articulated to the discourse of the time with respect to the approaches for the teaching of reading and writing and to social and pedagogical demands.
DOI: 10.6084/m9.figshare.9927218
title: Impact of artificial destratification on water availability of reservoirs in the Brazilian semiarid

description: Abstract: Field surveys and integral modelling were carried out to study the effect of bubble plumes on the flow hydrodynamics and the time-evolution of water temperature profiles in a shallow lake with maximum depth of about 4 m. Then, model simulations were performed to verify the feasibility of destratification of ten water-supply reservoirs with capacities of 10-2,000 hm3. Finally, hydrological modelling was conducted to assess the impact of destratification on evaporation suppression and its effects on reservoir yield. The results indicate that net temperature reductions of the order of 1.0°C can be obtained, which corresponds to evaporation suppressions of approximately 10%. In turn, this resulted in increases in the regulated flow of 2-12% that could be described by a general correlation. Lastly, a simplified feasibility analysis provided an operational cost of about 1.0 US$ per cubic meter of saved water, which suggests that artificial destratification cannot be discarded as an alternative for supplementing water supply in rural water-scarce regions.
DOI: 10.6084/m9.figshare.9927215
title: IMPROVEMENT OF METHANE STORAGE CAPACITY IN ACTIVATED CARBON BED WITH BIDISPERSE PACKING

description: Abstract This study presents a numerical investigation of the dynamics of methane adsorption in granular activated carbon beds with bidisperse packing in order to reduce the void spaces between the adsorbent particles and to improve the storage capacity in adsorbed natural gas vessels. Two distinct particle sizes (d and D) were used for the packing of the bidisperse bed, and the following particle size ratios were investigated: δ = d/D = 1 (monodisperse bed), 1/5, 1/10, 1/15, and 1/20. Compared with the monodisperse bed condition, the results obtained showed that bidisperse packing increases bed density by about 30% and methane storage capacity by up to 20%. The results also showed that the charging time could be optimized by increasing the pressure drop applied to the bed and that the storage capacity can be increased by cooling the admitted gas in the vessel.
DOI: 10.6084/m9.figshare.9927218.v1
title: Impact of artificial destratification on water availability of reservoirs in the Brazilian semiarid

description: Abstract: Field surveys and integral modelling were carried out to study the effect of bubble plumes on the flow hydrodynamics and the time-evolution of water temperature profiles in a shallow lake with maximum depth of about 4 m. Then, model simulations were performed to verify the feasibility of destratification of ten water-supply reservoirs with capacities of 10-2,000 hm3. Finally, hydrological modelling was conducted to assess the impact of destratification on evaporation suppression and its effects on reservoir yield. The results indicate that net temperature reductions of the order of 1.0°C can be obtained, which corresponds to evaporation suppressions of approximately 10%. In turn, this resulted in increases in the regulated flow of 2-12% that could be described by a general correlation. Lastly, a simplified feasibility analysis provided an operational cost of about 1.0 US$ per cubic meter of saved water, which suggests that artificial destratification cannot be discarded as an alternative for supplementing water supply in rural water-scarce regions.
DOI: 10.6084/m9.figshare.9927212
title: MODY probability calculator for GCK and HNF1A screening in a multiethnic background population

description: ABSTRACT Objective We aimed to identify the frequency of monogenic diabetes, which is poorly studied in multiethnic populations, due to GCK or HNF1A mutations in patients with suggestive clinical characteristics from the Brazilian population, as well as investigate if the MODY probability calculator (MPC) could help patients with their selection. Subjects and methods Inclusion criteria were patients with DM diagnosed before 35 years; body mass index &lt; 30 kg/m2; negative autoantibodies; and family history of DM in two or more generations. We sequenced HNF1A in 27 patients and GCK in seven subjects with asymptomatic mild fasting hyperglycemia. In addition, we calculated MODY probability with MPC. Results We identified 11 mutations in 34 patients (32.3%). We found three novel mutations. In the GCK group, six cases had mutations (85.7%), and their MODY probability on MPC was higher than 50%. In the HNF1A group, five of 27 individuals had mutations (18.5%). The MPC was higher than 75% in 11 subjects (including all five cases with HNF1A mutations). Conclusion Approximately one third of the studied patients have GCK or HNF1A mutations. Inclusion criteria included efficiency in detecting patients with GCK mutations but not for HNF1A mutations (&lt; 20%). MPC was helpful in narrowing the number of candidates for HNF1A screening.
DOI: 10.6084/m9.figshare.9927215.v1
title: IMPROVEMENT OF METHANE STORAGE CAPACITY IN ACTIVATED CARBON BED WITH BIDISPERSE PACKING

description: Abstract This study presents a numerical investigation of the dynamics of methane adsorption in granular activated carbon beds with bidisperse packing in order to reduce the void spaces between the adsorbent particles and to improve the storage capacity in adsorbed natural gas vessels. Two distinct particle sizes (d and D) were used for the packing of the bidisperse bed, and the following particle size ratios were investigated: δ = d/D = 1 (monodisperse bed), 1/5, 1/10, 1/15, and 1/20. Compared with the monodisperse bed condition, the results obtained showed that bidisperse packing increases bed density by about 30% and methane storage capacity by up to 20%. The results also showed that the charging time could be optimized by increasing the pressure drop applied to the bed and that the storage capacity can be increased by cooling the admitted gas in the vessel.
DOI: 10.6084/m9.figshare.9927224.v1
title: Quality of Life Assessment by the Endometriosis Health Profile (EHP-30) Questionnaire Prior to Treatment for Ovarian Endometriosis in Brazilian Women

description: Abstract Objective To evaluate the existence of an association between ultrasound findings and epidemiological and clinical factors using results obtained from the EHP-30 questionnaire in women with ovarian endometriosis. Methods A cross-sectional observational study was performed between July 2012 and May 2015, in which patients with chronic pelvic pain suggestive of endometrioma, as indicated by the results from a transvaginal pelvic ultrasonography, completed the standardized Endometriosis Health Profile - 30 (EHP-30) questionnaire to access quality-of-life scores before beginning treatment for endometriosis. A total of 65 patients were included. The data was analyzed in the statistical program IBM SPSS Statistics for Windows, Version 22.0 (IBM Corp., Armonk, NY, USA) for the comparison of data through linear multiple regression. Results The suitability of the linear regression model was confirmed by the histogram of the dependent variable and the residue distribution plot, confirming the trend of linearity as well as the homogeneous dispersion of the residues. The mean age of the patients was 39.7 ± 7.1 years old. Themajority was Caucasian (64.5%), had completed higher education (56.5%) and was nulligravida (40.3%). Infertility was present in 48.4% of the patients studied. Out of the total sample, 80.6% of the cases were symptomatic and complained mainly of acyclic pain, 79% of dysmenorrhea, and 61.3% of dyspareunia. This reflects the negative influence of endometriosis on the quality of life of patients with this disease. Conclusion Dyspareunia and acyclic pain were independent factors of correlation with high scores in the EHP-30 questionnaire, reflecting a worse quality of life.
DOI: 10.6084/m9.figshare.9927209
title: Prognostic factors in thyroid carcinomas: a 17-year outcome study

description: ABSTRACT Objectives The aim of our study was to evaluate the survival rate of all thyroid carcinomas (TCs) diagnosed in the 1999–2015 period in the Republic of North Macedonia and to analyze the prognostic influence of several characteristics on development of distant metastases, as well as to analyze the prognostic effect of seven clinical and constitutional features on mortality. Material and methods A retrospective analysis of medical data from all TCs diagnosed in 1999–2015 was performed. The survival rate of all types of TCs was estimated using the Kaplan Meier method. Univariate and multivariate logistic regression analysis was applied for evaluation of the predictive role of seven clinical and constitutional characteristics for development of distant metastases, and the univariate Cox-proportional model was applied for evaluation of the predictors for mortality. Results A total of 422 TC cases were diagnosed in the 17-year period, with an average survival time of 212.99 months. Results of the univariate regression analysis showed that dimension at initial ultrasound and histopathological type of tumor were significantly predictive variables for distant metastases. Multifocal tumors vs. unifocal tumors &lt; 15 mm significantly increased the probability of distant metastases by 7.401 (p = 0.005, 95% CI = 1.817–30.190) times. Age, initial lymph node involvement, number of radioiodine therapies, and histopathology of the tumor were selected as independent significant predictors for mortality. Conclusion Our results showed an excellent overall prognosis of thyroid tumors in the Macedonian population. The dimension of the tumor, multifocality, and histopathological type were the most relevant prognostic predictive features for development of distant metastases.
DOI: 10.6084/m9.figshare.9927200
title: Relationships among oncostatin M, insulin resistance, and chronic inflammation: a pilot study

description: ABSTRACT Objective Activated macrophages (M1-type macrophages) in adipose tissue secrete many proinflammatory cytokines that induce insulin resistance (IR). Oncostatin M (OSM), a member of the interleukin-6 (IL-6) family of Gp130 cytokines, plays an important role in a variety of biological functions, including the regulation of inflammatory responses. Proinflammatory cytokines released in patients with IR trigger a chronic, low-grade inflammatory reaction in blood vessel walls. This inflammator response leads to endothelial damage, which is the main mechanism for atherosclerosis and many cardiovascular diseases. Animal studies have reported a relationship between OSM and IR. To the best of our knowledge, however, few clinical studies have examined this topic. Therefore, we studied the relationship between serum levels of OSM and IR. Subjects and methods This prospective cross-sectional case-control study enrolled 50 people with IR (according to the HOMA-IR and QUICKI indices) and 34 healthy controls. The fasting blood concentrations of insulin, glucose, blood urea nitrogen (BUN), creatinine, aspartate aminotransferase (AST), alanine aminotransferase (ALT), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglyceride, total cholesterol, C-reactive protein (CRP), and OSM were determined. Results There were no significant differences between the two groups in age, sex, and HbA1c levels. Univariate analyses showed that waist circumference (WC) and levels of fasting glucose, insulin, CRP, HDL-C, OSM, HOMA-IR, and QUICKI differed between the two study groups. In multivariate analyses, both IR indices (QUICKI and HOMA) and OSM differed between the two groups. Conclusion OSM was correlated with the IR indices (QUICKI and HOMA). For simplicity, it might replace the other IR indices in the future. Further detailed studies are needed to confirm this.