cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.5281/zenodo.14158352
title: Natural Deep Eutectic Solvents Combined with Supercritical Carbon Dioxide for the Extraction of Curcuminoids from Turmeric

description: Article, Dataset for article

 

Abstract

Background: Curcuminoids, the bioactive compounds found in turmeric, exhibit potent antioxidant, anti-inflammatory, and neuroprotective properties. This study aims to enhance the extraction of curcuminoids from turmeric using environmentally friendly solvents supercritical CO2 (scCO2) combined with natural deep eutectic solvents (NADESs) in one process, and to evaluate the resulting biological activity. Methods: A Box–Behnken statistical design was applied to optimize scCO2 extraction conditions—pressure, CO2 volume, and temperature—to maximize curcuminoid yield. Next, the menthol and lactic acid NADESs were selected, and these two solvents were combined into a single turmeric extraction process. The biological activity of the resulting extract was evaluated using antioxidant assays (ferric reducing antioxidant power and 2,2-diphenyl-1-picrylhydrazyl) and enzyme inhibition assays (acetylcholinesterase, butyrylcholinesterase, and tyrosinase). Toxicity assessments were conducted on the aquatic invertebrates Daphnia pulex, Artemia sp., and Chironomus aprilinus. Results: The most effective extraction was achieved using a menthol–lactic acid NADES as a cosolvent, integrated at a 1:20 ratio of plant material to NADESs while in combination with scCO2. The optimized scCO2–NADES extraction resulted in a high curcuminoid yield (33.35 mg/g), outperforming scCO2 extraction (234.3 μg/g), NADESs ultrasound-assisted extraction (30.50 mg/g), and alcohol-based solvents (22.95–26.42 mg/g). In biological assays, the extract demonstrated significant antioxidant activity and effective inhibition of enzymes (acetylcholinesterase, butyrylcholinesterase, and tyrosinase). Toxicity studies showed a concentration-dependent response, with EC50 for Chironomus aprilinus at the level of 0.098 μL/mL and Daphnia pulex exhibiting high sensitivity to the extract. Conclusions: This study highlights the potential of combining NADESs and scCO2 extraction in one process, demonstrating the effectiveness of scCO2–NADES extraction in maximizing curcuminoid yield and enhancing bioactivity.

 



Keywords: 
turmeric; curcumin; supercritical carbon dioxide; natural deep eutectic solvent; neuroprotection
DOI: 10.5281/zenodo.14867723
title: Reconstitution of BNIP3/NIX-mitophagy initiation reveals hierarchical flexibility of the autophagy machinery

description: Selective autophagy is a lysosomal degradation pathway that is critical for maintaining cellular homeostasis by disposing of harmful cellular material. While the mechanisms by which soluble cargo receptors recruit the autophagy machinery are becoming increasingly clear, the principles governing how organelle-localized transmembrane cargo receptors initiate selective autophagy remain poorly understood. Here, we demonstrate that transmembrane cargo receptors can initiate autophagosome biogenesis not only by recruiting the upstream FIP200/ULK1 complex but also via a WIPI-ATG13 complex. This latter pathway is employed by the BNIP3/NIX receptors to trigger mitophagy. Additionally, other transmembrane mitophagy receptors, including FUNDC1 and BCL2L13, exclusively use the FIP200/ULK1 complex, while FKBP8 and the ER-phagy receptor TEX264 are capable of utilising both pathways to initiate autophagy. Our study defines the molecular rules for initiation by transmembrane cargo receptors, revealing remarkable flexibility in the assembly and activation of the autophagy machinery, with significant implications for therapeutic interventions.
DOI: 10.5281/zenodo.15109147
title: Reconstitution of BNIP3/NIX-mitophagy initiation reveals hierarchical flexibility of the autophagy machinery

description: Selective autophagy is a lysosomal degradation pathway that is critical for maintaining cellular homeostasis by disposing of harmful cellular material. While the mechanisms by which soluble cargo receptors recruit the autophagy machinery are becoming increasingly clear, the principles governing how organelle-localized transmembrane cargo receptors initiate selective autophagy remain poorly understood. Here, we demonstrate that transmembrane cargo receptors can initiate autophagosome biogenesis not only by recruiting the upstream FIP200/ULK1 complex but also via a WIPI-ATG13 complex. This latter pathway is employed by the BNIP3/NIX receptors to trigger mitophagy. Additionally, other transmembrane mitophagy receptors, including FUNDC1 and BCL2L13, exclusively use the FIP200/ULK1 complex, while FKBP8 and the ER-phagy receptor TEX264 are capable of utilising both pathways to initiate autophagy. Our study defines the molecular rules for initiation by transmembrane cargo receptors, revealing remarkable flexibility in the assembly and activation of the autophagy machinery, with significant implications for therapeutic interventions.
DOI: 10.5281/zenodo.14166391
title: Anticholinesterase Activity and Bioactive Compound Profiling of Six Hop (Humulus lupulus L.) Varieties

description: Article, Dataset for article

 



Abstract

Hops (Humulus lupulus L.) are widely recognized for their use in brewing, but they also possess significant pharmacological properties due to their rich bioactive compounds, with many varieties exhibiting diverse characteristics. This study investigates the chemical composition and biological activities of extracts from six hop varieties, focusing on quantifying xanthohumol and lupulone using High-Performance Liquid Chromatography (HPLC) and Total Phenolic Content (TPC) analysis. The hop varieties demonstrated significant variability in bioactive compound concentrations, with Aurora showing the highest xanthohumol (0.665 mg/g) and Zwiegniowski the highest lupulone (9.228 mg/g). TPC analysis revealed Aurora also had the highest phenolic content (22.47 mg GAE/g). Antioxidant activities were evaluated using DPPH, ABTS, CUPRAC, and FRAP assays, with Aurora and Oregon Fuggle displaying the most potent capacities. Aurora, in particular, showed the highest activity across multiple assays, including significant acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and tyrosinase inhibition, with IC50 values of 24.39 mg/mL, 20.38 mg/mL, and 9.37 mg/mL, respectively. The chelating activity was also assessed, with Apolon demonstrating the strongest metal ion binding capacity (IC50 = 1.04 mg/mL). Additionally, Aurora exhibited the most effective hyaluronidase inhibition (IC50 = 10.27 mg/mL), highlighting its potential for anti-inflammatory applications. The results underscore the influence of genetic and environmental factors on the bioactive compound profiles of hop varieties and their biological activity offering promising avenues for pharmaceutical and nutraceutical applications. However, further studies are needed to fully understand the potential interactions between hop cones components.






Keywords: 
hop; neuroprotection; acetylcholinesterase; butyrylcholinesterase; xanthohumol
DOI: 10.5281/zenodo.14166392
title: Anticholinesterase Activity and Bioactive Compound Profiling of Six Hop (Humulus lupulus L.) Varieties

description: Article, Dataset for article

 



Abstract

Hops (Humulus lupulus L.) are widely recognized for their use in brewing, but they also possess significant pharmacological properties due to their rich bioactive compounds, with many varieties exhibiting diverse characteristics. This study investigates the chemical composition and biological activities of extracts from six hop varieties, focusing on quantifying xanthohumol and lupulone using High-Performance Liquid Chromatography (HPLC) and Total Phenolic Content (TPC) analysis. The hop varieties demonstrated significant variability in bioactive compound concentrations, with Aurora showing the highest xanthohumol (0.665 mg/g) and Zwiegniowski the highest lupulone (9.228 mg/g). TPC analysis revealed Aurora also had the highest phenolic content (22.47 mg GAE/g). Antioxidant activities were evaluated using DPPH, ABTS, CUPRAC, and FRAP assays, with Aurora and Oregon Fuggle displaying the most potent capacities. Aurora, in particular, showed the highest activity across multiple assays, including significant acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and tyrosinase inhibition, with IC50 values of 24.39 mg/mL, 20.38 mg/mL, and 9.37 mg/mL, respectively. The chelating activity was also assessed, with Apolon demonstrating the strongest metal ion binding capacity (IC50 = 1.04 mg/mL). Additionally, Aurora exhibited the most effective hyaluronidase inhibition (IC50 = 10.27 mg/mL), highlighting its potential for anti-inflammatory applications. The results underscore the influence of genetic and environmental factors on the bioactive compound profiles of hop varieties and their biological activity offering promising avenues for pharmaceutical and nutraceutical applications. However, further studies are needed to fully understand the potential interactions between hop cones components.






Keywords: 
hop; neuroprotection; acetylcholinesterase; butyrylcholinesterase; xanthohumol
DOI: 10.5281/zenodo.15072708
title: Стурла Тордарсон [Sturla Þórðarson]

description: This biographical entry about the great Icelandic historian Sturla Þórðarson (1214 – 1284) has been prepared for the Big Russian Encyclopedia (Большая Российская Энциклопедия) and published in vol. 31 (2016).
DOI: 10.5281/zenodo.15072709
title: Стурла Тордарсон [Sturla Þórðarson]

description: This biographical entry about the great Icelandic historian Sturla Þórðarson (1214 – 1284) has been prepared for the Big Russian Encyclopedia (Большая Российская Энциклопедия) and published in vol. 31 (2016).
DOI: 10.6084/m9.figshare.28692392
title: [GPT e docentes] Suplemento com dados, análise, TCLE e questões da pesquisa

description: Trata-se de material suplementar com questões da pesquisa, TCLE e análise de dados
DOI: 10.6084/m9.figshare.28692392.v1
title: [GPT e docentes] Suplemento com dados, análise, TCLE e questões da pesquisa

description: Trata-se de material suplementar com questões da pesquisa, TCLE e análise de dados
DOI: 10.15468/dl.829e3s
title: Occurrence Download

description: A dataset containing 37526 species occurrences available in GBIF matching the query:
{
 "DatasetKey" : [
 "is Checklist and distribution of the species of Seychelles for conservationists"
 ]
}

 The dataset includes 37526 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0006797-250325103851331/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.9ashbn
title: Occurrence Download

description: A dataset containing 30 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is Mexico",
 "DatasetKey is one of (INSDC Sequences, University of Miami, Voss Marine Invertebrate Collections, International Barcode of Life project (iBOL), Biodiversity Research and Teaching Collections - TCWC Marine Invertebrates, NMNH Extant Specimen Records (USNM, US), Marine Invertebrate voucher specimens at the Florida Biodiversity Collection, Florida Fish and Wildlife Conservation Commission)",
 "OccurrenceStatus is Present",
 "TaxonKey is Octopus maya G.L.Voss & Solís, 1966"
 ]
}

 The dataset includes 30 records from 6 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0006800-250325103851331/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.2yvw5d
title: Occurrence Download

description: A dataset containing 695 species occurrences available in GBIF matching the query:
{
 "DatasetKey" : [
 "is National Water Vole Monitoring Programme (NWVMP)"
 ]
}

 The dataset includes 695 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0006799-250325103851331/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.e7ue8w
title: Occurrence Download

description: A dataset containing 9 species occurrences available in GBIF matching the query:
{
 "and" : [
 "BasisOfRecord is Human Observation",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "TaxonKey is Papilio bootes Westwood, 1842"
 ]
}

 The dataset includes 9 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0006801-250325103851331/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.6m77mm
title: Occurrence Download

description: A dataset containing 1191 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is Colombia",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 "TaxonKey is Magnolia Plum. ex L."
 ]
}

 The dataset includes 1191 records from 85 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0006802-250325103851331/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.5281/zenodo.15109193
title: Zaragoza, Male breadwinner 1924

description: Zaragoza, Male breadwinner 1924
DOI: 10.5281/zenodo.15109194
title: Zaragoza, Male breadwinner 1924

description: Zaragoza, Male breadwinner 1924
DOI: 10.15468/dl.jsbgfc
title: Occurrence Download

description: A dataset containing 66 species occurrences available in GBIF matching the query:
{
 "and" : [
 "BasisOfRecord is Human Observation",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "TaxonKey is Papilio liomedon Moore, 1874"
 ]
}

 The dataset includes 66 records from 2 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0006805-250325103851331/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.qdc4jg
title: Occurrence Download

description: A dataset containing 2 species occurrences available in GBIF matching the query:
{
 "and" : [
 "BasisOfRecord is Specimen",
 "DatasetKey is Snow Entomological Museum Collection",
 "TaxonKey is Eurymycter tricarinatus Pierce, 1930"
 ]
}

 The dataset includes 2 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0006804-250325103851331/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.6084/m9.figshare.28227191
title: Dataset accompanying publication "Large-scale analysis of environmental and ecological impacts of marine finfish aquaculture in the Mediterranean"

description: This is a dataset spanning five years of environmental monitoring of marine finfish farms in Greece. Data were collected from 343 stations near 106 fish farms and comprise macrofaunal data on family level as well as sediment parameters (granulometry) and geochemical data (total organic carbon, total nitrogen, total phosphorus, copper, zinc, redox measurements).Data presented here are anonymised to protect the identity of individual fish farms, thus farm names, company names and coordinates have been removed.
DOI: 10.15468/dl.dxthad
title: Occurrence Download

description: A dataset containing 141407702 species occurrences available in GBIF matching the query:
{
 "Country" : [
 "is Australia"
 ]
}

 The dataset includes 141407702 records from 3336 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0006777-250325103851331/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.60686/t-fsd3710
title: FSD3710 Membership Survey of Learned Societies 2022
DOI: 10.15468/dl.mzadw8
title: Occurrence Download

description: A dataset containing 11791 species occurrences available in GBIF matching the query:
{
 "DatasetKey" : [
 "is Datos de ocurrencia de triatominos americanos del Laboratorio de Triatominos del CEPAVE (CONICET-UNLP)"
 ]
}

 The dataset includes 11791 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0153183-200613084148143/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.60686/t-fsd3711
title: FSD3711 Citizens' Pulse 8/2022
DOI: 10.15468/dl.9lwwyi
title: Occurrence Download

description: A dataset containing 2224 species occurrences available in GBIF matching the query:
{
 "and" : [
 "DatasetKey is Invasive species - American bullfrog (Lithobates catesbeianus) in Flanders, Belgium",
 "TaxonKey is Lithobates catesbeianus (Shaw, 1802)"
 ]
}

 The dataset includes 2224 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0020635-180131172636756/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.kjbxpw
title: Occurrence Download

description: A dataset containing 1414 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is Myanmar",
 "OccurrenceStatus is Present",
 "TaxonKey is Rhododendron L."
 ]
}

 The dataset includes 1414 records from 18 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0005405-210819072339941/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.60686/t-fsd3718
title: FSD3718 Citizens' Pulse 9/2022
DOI: 10.60686/t-fsd3719
title: FSD3719 Public Procurement Notices 2020
DOI: 10.60686/t-fsd3720
title: FSD3720 Public Procurement Notices 2021
DOI: 10.15468/dl.ar0j0q
title: Occurrence Download

description: A dataset containing 3003 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Larrea tridentata (DC.) Coville"
 ]
}

 The dataset includes 3003 records from 62 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0020753-160910150852091/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.60686/t-fsd3723
title: FSD3723 News Articles about COVID-19 in Helsingin Sanomat, Asahi Shimbun and Dagens Nyheter 2020
DOI: 10.60686/t-fsd3724
title: FSD3724 Stories of my Dog's Life 2022
DOI: 10.60686/t-fsd3725
title: FSD3725 Citizens' Pulse 10/2022
DOI: 10.60686/t-fsd3726
title: FSD3726 Young Adults' Experiences of Limiting their Social Media Use 2021
DOI: 10.60686/t-fsd3727
title: FSD3727 Finnish Working Life Barometer 2021
DOI: 10.15468/dl.bijusv
title: Occurrence Download

description: A dataset containing 1239 species occurrences available in GBIF matching the query:
{
 "and" : [
 {
 "or" : [
 "TaxonKey is Tetropium fuscum (Fabricius, 1787)"
 ]
 },
 "HasCoordinate is true",
 "HasGeospatialIssue is false"
 ]
}

 The dataset includes 1239 records from 31 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0020636-180508205500799/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.60686/t-fsd3729
title: FSD3729 EVA Survey on Finnish Values and Attitudes Spring 2021
DOI: 10.60686/t-fsd3730
title: FSD3730 EVA Survey on Finnish Values and Attitudes Autumn 2021
DOI: 10.60686/t-fsd3731
title: FSD3731 EVA Survey on Finnish Values and Attitudes Spring 2022
DOI: 10.60686/t-fsd3733
title: FSD3733 Classroom Teachers' Experiences of Distance Teaching 2020
DOI: 10.60686/t-fsd3734
title: FSD3734 Classroom Teacher Students' Views on Reasons to Not Pursue Teacher Training 2019
DOI: 10.15468/dl.n0ykmv
title: Occurrence Download

description: A dataset containing 158429 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Dives dives (Deppe, 1830)"
 ]
}

 The dataset includes 158429 records from 80 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0020636-190415153152247/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.60686/t-fsd3736
title: FSD3736 Citizens' Pulse 11/2022
DOI: 10.60686/t-fsd3737
title: FSD3737 Church Resignation Forms Filed in Finland: Reasons for Resigning 2022
DOI: 10.60686/t-fsd3738
title: FSD3738 Finnish Experiences of Running Away from Substitute Care 2022-2023
DOI: 10.15468/dl.vl8enc
title: Occurrence Download

description: A dataset containing 7777 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Cardinalis cardinalis (Linnaeus, 1758)",
 "Geometry POLYGON((-68.55 -71.41,-68.55 81.77,12.30 81.77,12.30 -71.41,-68.55 -71.41))",
 "HasGeospatialIssue is false"
 ]
}

 The dataset includes 7777 records from 6 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0020634-160910150852091/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.60686/t-fsd3745
title: FSD3745 Finnish Values and Everyday Life 1999
DOI: 10.60686/t-fsd3746
title: FSD3746 Finnish Values and Everyday Life 2001
DOI: 10.60686/t-fsd3748
title: FSD3748 Finnish Values and Everyday Life 2005
DOI: 10.60686/t-fsd3749
title: FSD3749 Finnish Values and Everyday Life 2015
DOI: 10.15468/dl.4r0hon
title: Occurrence Download

description: A dataset containing 4722797 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is United States of America",
 "MediaType is Image"
 ]
}

 The dataset includes 4722797 records from 195 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0020638-180131172636756/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.60686/t-fsd3752
title: FSD3752 Finnish Opinions on Security Policy and National Defence 2022: Autumn
DOI: 10.60686/t-fsd3754
title: FSD3754 Public Procurement Notices 2022
DOI: 10.15468/dl.clesbn
title: Occurrence Download

description: A dataset containing 279 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Geranium wislizeni S.Watson"
 ]
}

 The dataset includes 279 records from 39 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0020638-190415153152247/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.60686/t-fsd3757
title: FSD3757 Citizens' Pulse 1/2023
DOI: 10.60686/t-fsd3758
title: FSD3758 Citizens' Pulse 2/2023
DOI: 10.60686/t-fsd3772
title: FSD3772 Experiences of Being Talked Past in the Daily Lives of Disabled People 2023
DOI: 10.60686/t-fsd3773
title: FSD3773 Citizens' Pulse 3/2023
DOI: 10.60686/t-fsd3776
title: FSD3776 Finnish Memories of Cars and Driving 2022
DOI: 10.60686/t-fsd3778
title: FSD3778 A Year of COVID-19: Finnish Experiences of Everyday Life during the Pandemic 2021
DOI: 10.60686/t-fsd3780
title: FSD3780 EVA Survey on Finnish Values and Attitudes Autumn 2022
DOI: 10.60686/t-fsd3781
title: FSD3781 EVA Survey on Finnish Values and Attitudes Spring 2023
DOI: 10.60686/t-fsd3782
title: FSD3782 Citizens' Pulse 4/2023
DOI: 10.60686/t-fsd3783
title: FSD3783 Citizens' Pulse: Combined Data 2022
DOI: 10.60686/t-fsd3784
title: FSD3784 Finnish Working Life Barometer 2022
DOI: 10.60686/t-fsd3785
title: FSD3785 Finnish Science Barometer 2022
DOI: 10.60686/t-fsd3788
title: FSD3788 Register Data on Vacancies Notified to Public Employment Service 2022
DOI: 10.60686/t-fsd3789
title: FSD3789 Citizens' Opinion: Parliamentary Election Surveys 2023
DOI: 10.60686/t-fsd3790
title: FSD3790 Citizens' Pulse 5/2023
DOI: 10.60686/t-fsd3804
title: FSD3804 Workplace Well-Being in the Public Sector 2022
DOI: 10.60686/t-fsd3808
title: FSD3808 Citizens' Pulse 6/2023
DOI: 10.60686/t-fsd3820
title: FSD3820 Culture and Leisure in Finland 2018
DOI: 10.60686/t-fsd3821
title: FSD3821 Citizen's Pulse 7/2023