cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.17632/6t33n6nm96.3
title: CTCF modulates allele-specific sub-TAD organisation and imprinted gene activity at the mouse Dlk1-Dio3 and Igf2-H19 domains

description: Processed 4C-seq data sets for viewpoints in the Igf2-H19 and Dlk1-Dio3 domains
DOI: 10.17632/8jj7865wfn.1
title: Plugins for QC EUREF compliant

description: Zipped file of jars to use the MAMMO_QC plugins in ImageJ
DOI: 10.17632/z8wsncxg5b.2
title: Comprehensive effects of LVAD speed changes on alveolar gas exchange, sleep ventilatory pattern, and exercise performance

description: Background. Increasing left ventricular assist device (LVAD) pump speed according to patients’ activity is a fascinating hypothesis. This paper is an analysis of the short-term effects of LVAD speed increase on cardiopulmonary exercise performance, muscle oxygenation (NIRS), lung diffusion capacity (DLCO and DLNO), and sleep quality. Methods. We analyzed CPET, DLCO and DLNO, and sleep in 33 Jarvik 2000 LVAD patients. After a maximal cardiopulmonary exercise test (CPET, n=28), patients underwent two maximal CPETs with LVAD speed randomly set at 3 or increased from 3 to 5 during effort (n=15). Then, at LVAD speed randomly set at 2 or 4, we performed: a) constant workload CPETs assessing O2 kinetics, cardiac output (CO), and muscle oxygenation (n=15); b) resting DLCO and DLNO (n=18); c) nocturnal cardiorespiratory monitoring (n=29). Results. The progressive pump speed increase raised peak VO2 (12.5±2.5 ml/min/kg vs. 11.7±2.8 at speed 3; p=0.001). During constant workload, from speed 2 to 4, CO increased (3.18±0.76 L/min vs. 3.69±0.75, p=0.015, at rest; 5.91±1.31 L/min vs. 6.69±0.99, p=0.014, during exercise), and system efficiency (τ= 65.8±15.1 sec vs. 49.9±14.8, p=0.002) and muscle oxygenation improved. At speed 4, DLCO decreased, and obstructive apneas increased despite a significant apnea/hypopnea index and a reduction of central apneas. Conclusion. Short-term LVAD speed increase improves exercise performance, CO, O2 kinetics, and muscle oxygenation. However, it deteriorates lung diffusion, and it increases obstructive apneas, likely due to an increase of intrathoracic fluids. Self-adjusting LVAD speed is a fascinating but possibly unsafe option, probably requiring a monitoring of intrathoracic fluids.
DOI: 10.6085/aa/istcxx_xxxitbpxmsr00_20080101.50.4
title: MARINe/PISCO: Intertidal: site temperature data: Stillwater (ISTCXX)

description: This metadata record describes a mix of intertidal seawater and air temperature data collected at Stillwater by MARINe/PISCO. Measurements were collected using Temperature Loggers from Onset Computer Corp
DOI: 10.17632/2m77rcd8nr.1
title: Supplementary videos for PhD: 'Developing Imaging and Spectroscopy Capabilities in Liquid-Phase Transmission Electron Microscopy'
DOI: 10.17632/9b9562ppz9.1
title: Rabbit umbilical cord mesenchymal stem cells: a new option for cytotherapy

description: Background: Cytotherapy is considered a promising treatment for some refractory diseases. Mesenchymal stem cells (MSCs) from animals, which can potentially provide an unlimited supply compared to humans, are a promising alternative to satisfy the medical demand for xenotransplantation. Methods: Here, the structure of the rabbit umbilical cord were analyzed and compared with that of human umbilical cord. We isolated and cultured the rUCMSCs in vitro and used CCK-8 to detect cell proliferation activity of rUCMSCs. Then, we studied the immunological characteristics of rUCMSCs by using MLR, flow cytometry and ELISA test. Futhermore, the complexes formed by rUCMSC and HA/TCP were used to repair the rat cranial defect model in vivo study. By using radiological, histological and immunohistochemistry methods, we detected the efficacy and safety of rUCMSCs in a xenogeneic host. Findings: In this study, we found that there were no histological differences between rabbit and human umbilical cords. So, rUCMSCs were successfully isolated and cultured refering to the method of isolating hUCMSCs. Then, we found that the proliferation rate of rUCMSCs was significantly higher than that of human UCMSCs. Furthermore, we showed that rUCMSCs not only have immune suppression capability , but also have low immunogenicity in both allogeneic and xenogeneic immune responses. Finally, we demonstrated that rUCMSCs can promote osteogenesis and inhibit the inflammatory reaction in heterogeneous hosts. Interpretation: rUCMSCs may be a new source of cells for cytotherapy and tissue engineering.
DOI: 10.17632/scjbzk4tkh.1
title: Dose-dependent efficacy of β-blocker in patients with chronic heart failure and atrial fibrillation

description: BACKGROUND: The usefulness of β-blockers in heart failure (HF) patients with permanent atrial fibrillation (AF) has been questioned. METHODS AND RESULTS: We analyzed data from HF patients (958 patients (801 males, 84%, age 67 ± 11 years)) with AF enrolled in the MECKI score database. We evaluated prognosis (composite of cardiovascular death, urgent heart transplant, or left ventricular assist device) of patients receiving β-blockers (n = 777, 81%) vs. those not treated with β-blockers (n = 181, 19%). We also analyzed the role β1-selectivity and the role of daily β-blocker dose. To account for different HF severity, Kaplan-Meier survival curves were normalized for relevant confounding factors and for treatment strategies. Dose was available in 629 patients. Median follow-up was 1312 (577-2304) days in the entire population, 1203 (614-2420) and 1325 (569-2300) days in patients not receiving and receiving β-blockers. 224 (23%, 54/1000 events/year), 163 (21%, 79/1000 events/year), and 61 (34%, 49/1000 events/year) events were recorded, respectively. At 10-year patients treated with β-blockers had a better outcome (HR 0.447, p
DOI: 10.5519/qd.1i8a4mev
title: Query on the Natural History Museum Data Portal (data.nhm.ac.uk) (180 records)
DOI: 10.17632/kdhmzrj3jr.1
title: The centre of gravity of the human body in dynamic condition

description: The research carried out has shown that the greatest influence on position of the ellipse describing the position of the center of gravity of the human body has the inclination angle of the wheelchair. By controlling the change in the inclination angle value in the range from 0 ° to 5.4 °, standard deviation of the length of the horizontal half-axis of the ellipse (SD a) equal to 31.2 mm was obtained. For comparison, in case of changing the frequency of pushes (40 to 50 pushes per minute) of the wheelchair at a constant inclination angle, the standard deviation of the horizontal half-axis length (SD a) equal to 8 mm was recorded. The results of the study show a change in the position of the center of gravity of the human body in dynamic conditions. They are relative to the contact points of the wheelchair wheels with the ground. Using the dimensions of the plotted ellipses one can determine the values of pressure that affect the wheelchair's individual wheels.
DOI: 10.17632/sjzs3wpgf8.1
title: Improvement in exercise capacity and delayed anaerobic metabolism induced by far-infrared-emitting garments in active healthy subjects: A pilot study

description: Background Far-infrared-emitting garments have several biological properties including the capability to increase blood perfusion in irradiated tissues. Design The aim of the study was to evaluate whether far-infrared radiation increases exercise capacity and delays anaerobic metabolism in healthy subjects. Methods With a double-blind, crossover protocol, a maximal cardiopulmonary exercise test was performed in 20 volunteers, wearing far-infrared or common sport clothes, identical in texture and colour. Results Comparing far-infrared with placebo garments, higher oxygen uptake at peak of exercise and longer endurance time were observed (peak oxygen uptake 38.0 ± 8.9 vs. 36.2 ± 8.5 ml/kg/min, endurance time 592 ± 85 vs. 570 ± 71 seconds; P
DOI: 10.17632/zj42tj3z3j.1
title: ST2 and B-type natriuretic peptide kinetics during exercise in severe heart failure

description: In chronic heart failure (HF), risk stratification is one of the most challenging issues, with a plethora of biomarkers available for this purpose. The key role is played by B-type natriuretic peptide (BNP) and/or its amino-terminal fragment NT-proBNP. Accordingly, all new biomarkers must be compared with BNP and/or must be characterized by prognostic capability in selected HF populations. Soluble ST2 has been recently introduced among the new biomarkers. The presence of high levels of ST2 is related to the severity of HF and to an increased risk of complications, such as arrhythmias, acute decompensation, and death, independently of natriuretic peptide. Indeed, a prognostic role of ST2 has been suggested in low-risk populations, in patients with chronic , advanced, and acute heart failure. Regardless, at present, the most defined role of ST2 is to provide a prognostic value additive to that of NT-proBNP within a multiparametric prognostic approach. The changes in ST2 in response to an acute hemodynamic event are presently unknown, and specifically it is unknown whether an ST2 response to an acute hemodynamic event has the same magnitude and time frame of that reported for BNP. Indeed, in patients with severe HF, BNP increases even during a 10-minute maximal exercise, probably mirroring acute pulmonary hemodynamic worsening. We studied 30 (67±10 years, 28M) consecutive patients with chronic severe HF. Patients underwent a 10-minute cycle-ergometer ramp cardiopulmonary exercise test (CPET) protocol. Immediately before exercise and at peak exercise, venous blood was sampled for BNP and ST2 determination. At the same time, lung diffusion (DLCO) and its two components membrane diffusion (DM) and capillary volume (Vcap) were measured. DLCO was measured by the single-breath constant expiratory flow technique. We showed, using a simple but intriguing physiological research model, that exercise-induced hemodynamic impairment is associated with a major increase of BNP but not of ST2, confirming that the causes and/or the time frame of their responses to acute and short-lasting pulmonary pressure increase are different.
DOI: 10.17632/5d59s4t8xn.1
title: Transthoracic echocardiography in patients undergoing mitral valve repair: comparison of new transthoracic 3D techniques to 2D transoesophageal echocardiography in the localization of mitral valve prolapse

description: Successful mitral valve (MV) repair for degenerative mitral regurgitation (DMR) is mainly related to surgical expertise and MV anatomy. Although 2D echocardiography, specifically transoesophageal (TOE), provides precise information regarding MV anatomy, recent advancements in matrix technology meant a decisive step forward to the point where segmental MV analysis can be accurately performed from a noninvasive 3D transthoracic (TTE) approach. The aims of this study were: (a) to evaluate the feasibility and time required for real-time 3D TTE in a large consecutive cohort of patients with severe DMR in the assessment of MV anatomy; (b) to compare the accuracy of 3D TTE and 2D TOE versus surgical inspection in the recognition and localization of all components of the MV leaflets; (c) to establish the added diagnostic value of 3D colour- Doppler examination to pure 3D morphologic evaluation. 149 consecutive patients with severe DMR underwent complete 3D TTE before surgery and 2D TOE in the operating room. Echocardiographic data obtained by the different techniques were compared with surgical inspection. 3D TTE was feasible in a relatively short time (8 ± 4 min), with good (49%) and optimal (33%) imaging quality in the majority of cases. 3D TTE had significant better overall accuracy compared to 2D TOE (93 and 91%, p &lt; 0.05, respectively). 2D TOE was significantly more specific than 3D TTE in the identification of A3 prolapse (99 vs. 96%). The colourDoppler mode did not improve significantly the accuracy of 3D TTE, albeit it determined a better sensitivity in the detection of A2 prolapse if compared to 2D TOE (95 vs. 85%). 3D TTE with or without colourDoppler is a feasible and useful method in the analysis of MV prolapse; it allows a preoperative and noninvasive description of the pathology as accurate as the 2D TOE.
DOI: 10.17632/8wj8gpgwmr.1
title: Suspended_Conditions_Muscle_Activity_Acceleration_Force_ICC_Correlation

description: This spreadsheet provides data concerning body center of mass acceleration, muscle activity, and forces exerted during a suspended lunge under different conditions of stability in high-standard track and field athletes. Also, the spreadsheet shows the Interclass Correlation Coeficient (ICC) values for each dependent variable (acceleration, muscle activity and force) and exercise condition. Besides, the correlations values of each suspended lunge between muscle activity, force and acceleration.
DOI: 10.17632/w7r8zn5t8b.1
title: Comprehensive Assessment of Mitral Valve Geometry and Cardiac Remodeling With 3-Dimensional Echocardiography After Percutaneous Mitral Valve Repair

description: MitraClip is a validated treatment for significant mitral regurgitation (MR) in high risk patients. Aims of the study were to evaluate immediate changes in mitral valve (MV) geometry induced by MitraClip and correlations between baseline geometry and cardiac remodeling. Eighty patients undergoing MitraClip for primary (48%) or secondary (52%) MR were enrolled. Intraoperative transesophageal echocardiographic 3D images were acquired immediately before and after the procedure for MV annulus (MVA) morphology analysis. Transthoracic 3D echocardiography was performed pre-operatively and at 6 months follow-up (6MFU). Patients were classified on the basis of MR reduction (ΔMR) at 6MFU as Optimal (ΔMR≥2) or Suboptimal (ΔMR&lt;2). An optimal result was reached in 60 (75%) patients, whereas 20 subjects showed a ΔMR&lt;2 at 6MFU. The Optimal showed significantly smaller baseline MVA (antero-posterior diameter 4.05±0.59 vs. 4.43±0.68cm; anterolateral-posteromedial diameter 4.38±0.56 vs. 4.70±0.73cm; MVA circumference 14.1±1.7 vs. 15.1±2.3cm and 3D area 14.8±3.9 vs. 17.4±5.3cm2), lower sphericity index and non-planar angle compared to Suboptimal. A value of antero-posterior diameter ≥4.44 cm was identified (ROC curve) as a possible cut-off for pre-operative identification of Suboptimal patients. Post-operatively, MitraClip reduced MVA flattening (non-planar angle), sphericity index and size (as expressed by antero-posterior diameter, MVA circumference and area). At 6MFU the Optimal showed significant decrease in left ventricular volumes and pulmonary artery systolic pressure. In conclusion, MitraClip induces remarkable changes in MVA geometry and favorable LV remodeling is detected in patients with optimal mid-term outcome. A pre-procedural antero-posterior diameter &lt;4.44cm seems to be a potential predictor of mid-term optimal result.
DOI: 10.17632/z23ht6f2jb.1
title: Prevalence and factors associated with preoperative parental anxiety among parents of children undergoing Anesthesia and Surgery at University of Gondar Hospital, North West Ethiopia, 2019: A cross-sectional study

description: SPSS data
DOI: 10.25387/g3.9801638
title: Supplementary Material for Evangelou et al. 2019

description: Supplementary Material for Evangelou et al.<br>
DOI: 10.25387/g3.9801638.v1
title: Supplementary Material for Evangelou et al. 2019

description: Supplementary Material for Evangelou et al.<br>
DOI: 10.17632/g5k9pk3m59.1
title: Exercise performance, haemodynamics, and respiratory pattern do not identify heart failure patients who end exercise with dyspnoea from those with fatigue

description: Aims: The two main symptoms referred by chronic heart failure (HF) patients as the causes of exercise termination during maximal cardiopulmonary exercise test (CPET) are muscular fatigue and dyspnea. So far, a physiological explanation why some HF patients end exercise because of dyspnea and others because of fatigue is not available. We assessed whether patients referring dyspnea or muscular fatigue may be distinguished by different ventilator or hemodynamic behavior during exercise. Methods and Results: We analyzed exercise data of 170 consecutive HF patients with reduced left ventricular ejection fraction in stable clinical condition. All patients underwent to maximal CPET and to a second maximal CPET with measurement of cardiac output (CPET-CO) by inert gas rebreathing at peak exercise. Thirty-eight (age 65.0±11.1y) and 132 (65.1±11.4y) patients terminated CPET because of dyspnea and fatigue, respectively. Hemodynamic and cardiorespiratory parameters were the same in fatigue and dyspnea patients. VO2 was 10.4±3.2 and 10.5±3.3 ml/min/kg at the anaerobic threshold and 15.5±4.8 and 15.4±4.3 at peak, in fatigue and dyspnea patients, respectively. In fatigue and dyspnea patients peak heart rate was 110±22 and 114±22 b/min, VE/VCO2 and VO2/work relationship slopes were 31.2±6.8 and 30.6±8.2 and 10.6±4.2 and 11.4±5.5 L/min/Watts, respectively. Peak CO was 6.68±2.51 and 6.21±2.55 L/min (p=NS for all). Conclusions: in chronic HF patients in stable clinical condition, fatigue and dyspnea as reasons of exercise termination do not highlight different ventilatory or hemodynamic patterns during effort.
DOI: 10.17632/jb2hc4z7gw.1
title: Mitral Annular Disjunction in a Large Cohort of Patients With Mitral Valve Prolapse and Significant Regurgitation

description: The study aimed to assess the prevalence of mitral annular disjunction (MAD) in a large cohort of unselected patients with mitral valve prolapse (MVP) and severe mitral regurgitation (MR) and identify any association between MAD and MVP etiology or mitral valve (MV) anatomy. MAD is a detachment between the ventricular myocardium and the atrial wall-posterior MV annulus (MVA), considered closely linked to Barlow’s disease (BD). Discordant data exist regarding MAD prevalence in MVP with different grades of MR. A total of 979 patients with MVP, either affected by BD or fibroelastic deficiency (FED), with clinically significant MR requiring surgery were enrolled. Pre-operative 2D transthoracic (TTE) or intraoperative transesophageal (TEE) echo examinations were retrospectively reviewed for the assessment of MAD. MVA dimensions and MV morphology at 2DTTE were also noted. The population included 637 (65%) patients with BD and 342 (35%) with FED. The overall prevalence of MAD was 16.2%: 21.8% and 5.8% in the BD and FED groups, respectively. Patients with MAD were significantly younger, had significantly larger MVA diameters (septo-lateral diameter 41[37-44] vs. 39[36-42]mm; anterolateral diameter 38[34-41] vs. 36[33-40]mm), lower incidence of chordal rupture (61.0% vs. 75.7%), higher prevalence of bileaflet prolapse (47.8% vs. 25.9%) and higher number of prolapsing scallops compared with those without MAD. In a large cohort of patients with advanced MVP and severe MR, MAD prevalence is lower than that reported in other populations of MVP. MVA detachment can be observed not only in BD patients, but also in a minority of patients with FED, suggesting that MAD might be an anatomical feature of the MVA per se, determining dilatation and distortion of the MVA, that may accelerate the progression of MV disease in patients with predisposition to it because of genetics (BD) or just because of aging (FED).
DOI: 10.7910/dvn/ljn4bo/edojhp
title: Hansen_Tyner_R_Replication_Code.R

description: :unav
DOI: 10.7910/dvn/ljn4bo/quzsge
title: Hansen_Tyner_Codebook.docx

description: :unav
DOI: 10.17632/3yn6tjz9ds.1
title: Qualitative and quantitative evaluation of a new wearable device for ECG and respiratory Holter monitoring

description: Background: Recent advances in wearable technology make continuous cardiorespiratory monitoring possible, with potential applications in assessment of cardiopulmonary patients, healthy subjects and athletes. The aim of the present study was to qualitatively and quantitatively evaluate a new wearable device (Learn Inspire Free Entertain = L.I.F.E.) by embedding in a compression shirt a 12‑lead ECG system and 5 respiratory sensors. Methods: Thirty cardiorespiratory patients and ten healthy subjects were studied for 24 h during their usual life activities. In 8 healthy subjects, simultaneous measurements of the device and of an ergo-spirometer were performed during different levels of ventilation in five different body positions. The quality of ECG signals in terms of measurability of heart rate, P wave, QRS complex and ST segment, was analyzed by four expert cardiologists/respiratory physiologists using an arbitrary 1–5 scale. The sum of the respiratory signals was used to calculate the respiratory rate, inspiratory time and relative changes of tidal volume. These parameters were compared to ergo-spirometer measurements. Results: Median quality value was &gt;3 for heart rate, QRS complex, ST segment and P wave (except in L3, aVL, aVF, V1 and V2 leads). Median quality of respiratory traces was &gt;4 in patients and between 3 and 4 in healthy subjects. The respiratory monitoring of respiratory rate and inspiratory time was accurate in all body positions. Tidal volumes were underestimated due to a high level of ventilation. Conclusions: The L.I.F.E. device provides an accurate continuous monitoring of cardiorespiratory signals during the 24 h both in normal subjects and cardiorespiratory patients.
DOI: 10.17632/7zmymh2f5z.2
title: V.V. Dokuchaev Soil Science Institute TD-PY SOM derivatives classification

description: Contain more than 2000 compounds are indentified by NIST after pyrolysis GC MS of Chernozem soils. All substances are divided into classes according to their alleged origin: Polysaccharide derivatives, Nitrogen containing compounds, Aliphatic , Polyaromatic hydrocarbons, Lignin coumaric derivative, Lignine guaiacol derivative, Lignine syringic derivative, Aromatic, Indane, inden containing, Other and Artifact of column or packing.
DOI: 10.17632/d3s5bgpky2.1
title: Cyclic data

description: Excel files with raw data from MTS controller and calculated columns for quantities such as stress and strain.
DOI: 10.17632/fhg2gt5ft9.2
title: V.V. Dokuchaev Soil Science Institute TD-PY SOM N-compounds derivatives classification

description: Contain about 600 N-compounds are indentified by NIST 11 after pyrolysis GC MS of Chernozem soils. All substances are divided into classes according to presence N-moieties: amides, amines, anilines, azoles, diazines, indoles, nitriles, pyridines, pyrroles, quinolines, other n containing compounds and amino acids.
DOI: 10.7910/dvn/ljn4bo/5w9m69
title: anes_timeseries_2016.tab

description: :unav
DOI: 10.7910/dvn/ljn4bo/a8h4ai
title: CCES_2016.dta

description: :unav
DOI: 10.7910/dvn/ljn4bo/e9xks1
title: Hansen_Tyner_Stata_Replication_Code.txt

description: :unav
DOI: 10.7910/dvn/ljn4bo/pu6zxw
title: hansen_tyner_mturk.tab

description: :unav
DOI: 10.7910/dvn/ljn4bo/u9qffk
title: ReadMe.txt

description: :unav
DOI: 10.17632/9mz6dr26gd.1
title: Alessio and Keller (2019) Short-term patterns and processes of coastal cliff erosion in Santa Barbara, CA.

description: Retreat rates and wave data used in plots
DOI: 10.5281/zenodo.3452105
title: LDBC-SNB SF-0001 and SF-0003 Datasets

description: This datasets generated with the LDBC SNB Data generator. https://github.com/ldbc/ldbc_snb_datagen It corresponds to Scale Factors 1 and 3. They are used in the following paper: An early look at the LDBC social network benchmark's business intelligence workload 10.1145/3210259.3210268
DOI: 10.5281/zenodo.3452106
title: LDBC-SNB SF-0001 and SF-0003 Datasets

description: This datasets generated with the LDBC SNB Data generator. https://github.com/ldbc/ldbc_snb_datagen It corresponds to Scale Factors 1 and 3. They are used in the following paper: An early look at the LDBC social network benchmark's business intelligence workload 10.1145/3210259.3210268
DOI: 10.17632/265wr3pr47.1
title: 2018-30217223

description: Clinical and functional data derived from the RECARDIO I trial.
DOI: 10.17632/fnkv4sx94v.1
title: Catalepsy Bar

description: These are the files required to build a fully functional Automated Catalepsy Bar Test.