cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.5281/zenodo.3245316
title: Human Kelch-like Protein 20 (KLHL20); A Target Enabling Package

description: The BTB-Kelch protein KLHL20 is a hypoxia-induced CUL3-dependent E3 ligase linked to autophagy, Alzheimer’s disease and cancer. KLHL20 acts to terminate autophagy by promoting the ubiquitination and degradation of ULK1. KLHL20 is also reported as a top 20 biomarker for Alzheimer’s disease progression. Inhibition of KLHL20 may be neuroprotective by extending autophagy for the clearance of neurotoxic proteins aggregates. KLHL20 also promotes cancer through the ubiquitination and degradation of tumour suppressors including PML and DAPK1. We have solved the 1.1 Å structure of the Kelch domain of KLHL20 in complex with a DAPK1 peptide. We have used biophysical and cellular studies to validate this peptide site as a degron site for DAPK1 degradation. Using this peptide, we have also established alpha screen and HTRF assays to identify potent small molecule covalent inhibitors that compete with DAPK1 for binding to the Kelch domain of KLHL20.
description: Future versions of this document will contain experimental data about the KLHL20 TEP.
DOI: 10.5281/zenodo.3245488
title: Slip model and Relative Source Time Functions for the 2013 Mw 3.3 St. Gallen earthquake

description: Slip model and Relative Source Time Functions for the the 2013 Mw 3.3 St. Gallen earthquake
DOI: 10.5281/zenodo.3246041
title: Human Kelch-like Protein 20 (KLHL20); A Target Enabling Package

description: The BTB-Kelch protein KLHL20 is a hypoxia-induced CUL3-dependent E3 ligase linked to autophagy, Alzheimer’s disease and cancer. KLHL20 acts to terminate autophagy by promoting the ubiquitination and degradation of ULK1. KLHL20 is also reported as a top 20 biomarker for Alzheimer’s disease progression. Inhibition of KLHL20 may be neuroprotective by extending autophagy for the clearance of neurotoxic proteins aggregates. KLHL20 also promotes cancer through the ubiquitination and degradation of tumour suppressors including PML and DAPK1. We have solved the 1.1 Å structure of the Kelch domain of KLHL20 in complex with a DAPK1 peptide. We have used biophysical and cellular studies to validate this peptide site as a degron site for DAPK1 degradation. Using this peptide, we have also established alpha screen and HTRF assays to identify potent small molecule covalent inhibitors that compete with DAPK1 for binding to the Kelch domain of KLHL20.
description: This document represents version 1 of the TEP datasheet and includes all updates on the project as of April 2019. For more information about TEPs and the TEP Programme, please visit https://thesgc.org/tep
DOI: 10.7910/dvn/ve6vsr/hupnst
title: interaction.R

description: :unav
DOI: 10.7910/dvn/ve6vsr/i7sfiz
title: attrition.R

description: :unav
DOI: 10.7910/dvn/ve6vsr/kuwnhg
title: noncompliance.R

description: :unav
DOI: 10.7910/dvn/ve6vsr/lgkyfq
title: covariate_adjustment.R

description: :unav
DOI: 10.7910/dvn/ve6vsr/ltmnun
title: blocked.R

description: :unav
DOI: 10.7910/dvn/ve6vsr/rwnojp
title: clustered.R

description: :unav
DOI: 10.7910/dvn/ve6vsr/sovxns
title: interaction_simulated_data.tab

description: :unav
DOI: 10.7910/dvn/ve6vsr/x979rq
title: covariate_simulated_data.tab

description: :unav
DOI: 10.17632/32n5vbvpvk.1
title: Meitei Mayek Signatures

description: Manipuri signatures used for signature verification and recognition. Data(Genuine Signatures) were gathered from 81 Manipuri individuals and another data gathering process were done where forged signatures for the respective genuine signatures were gathered.
DOI: 10.5281/zenodo.3245351
title: Human TMEM16K (ANO10); A Target Enabling Package

description: There are ten members of the TMEM16/Anoctamin family of proteins in mammals. Although the first members of this family to be discovered, TMEM16A and TMEM16B, have a calcium-regulated chloride channel function, subsequently other members of the family, such as TMEM16F, were found to have lipid scramblase activity combined with non-selective ion channel activity. TMEM16K was a relatively understudied member of the family despite the observation that mutations in TMEM16K have been linked to the genetic disease autosomal recessive spinocerebellar ataxia Type 10 (Also known as SCAR10 or ARCA3). SCAR10 is a late-onset neurodegenerative disorder which causes marked atrophy of the cerebellum with consequential deterioration in limb co-ordination, speech and eye movement. We have solved several structures of human TMEM16K through X-ray crystallography and cryo-EM capturing both active and inactive conformational states. Through collaborations, we have investigated TMEM16K’s function and location in cells. We were able to show that TMEM16K acts as a lipid scramblase with non-selective ion channel activity that is sensitive to both Ca<sup>2+</sup> and lipid chain lengths. We also showed that TMEM16K mainly resides in the endoplasmic reticulum where it may be regulated by the ER’s unique lipid profile. Our highest resolution cryo-EM structure for TMEM16K allowed us to identify a bound lipid in the cavity behind the groove that transports the lipid headgroups and this lipid binding site may represent an allosteric modulator site, providing a direction for the design of binders which could modulate TMEM16K activity in cells.
description: Future versions of this document will contain experimental data about the TMEM16K TEP.
DOI: 10.7910/dvn/ve6vsr/8oknhl
title: two_arm_trial.R

description: :unav
DOI: 10.7910/dvn/ve6vsr/eyqle8
title: clustered_simulated_data.tab

description: :unav
DOI: 10.7910/dvn/ve6vsr/m4ih0q
title: blocked_simulated_data.tab

description: :unav
DOI: 10.7910/dvn/ve6vsr/opiqmk
title: make_datasets.R

description: :unav
DOI: 10.7910/dvn/ve6vsr/0nbh27
title: two_arm_trial.do

description: :unav
DOI: 10.7910/dvn/ve6vsr/dtj067
title: README.txt

description: :unav
DOI: 10.7910/dvn/ve6vsr/oof4up
title: attrition_simulated_data.tab

description: :unav
DOI: 10.7910/dvn/ve6vsr/v3gqeo
title: noncompliance_simulated_data.tab

description: :unav
DOI: 10.5281/zenodo.3246044
title: Human TMEM16K (ANO10); A Target Enabling Package

description: There are ten members of the TMEM16/Anoctamin family of proteins in mammals. Although the first members of this family to be discovered, TMEM16A and TMEM16B, have a calcium-regulated chloride channel function, subsequently other members of the family, such as TMEM16F, were found to have lipid scramblase activity combined with non-selective ion channel activity. TMEM16K was a relatively understudied member of the family despite the observation that mutations in TMEM16K have been linked to the genetic disease autosomal recessive spinocerebellar ataxia Type 10 (Also known as SCAR10 or ARCA3). SCAR10 is a late-onset neurodegenerative disorder which causes marked atrophy of the cerebellum with consequential deterioration in limb co-ordination, speech and eye movement. We have solved several structures of human TMEM16K through X-ray crystallography and cryo-EM capturing both active and inactive conformational states. Through collaborations, we have investigated TMEM16K’s function and location in cells. We were able to show that TMEM16K acts as a lipid scramblase with non-selective ion channel activity that is sensitive to both Ca<sup>2+</sup> and lipid chain lengths. We also showed that TMEM16K mainly resides in the endoplasmic reticulum where it may be regulated by the ER’s unique lipid profile. Our highest resolution cryo-EM structure for TMEM16K allowed us to identify a bound lipid in the cavity behind the groove that transports the lipid headgroups and this lipid binding site may represent an allosteric modulator site, providing a direction for the design of binders which could modulate TMEM16K activity in cells.
description: This document represents version 1 of the TEP datasheet and includes all updates on the project as of June 2019. For more information about TEPs and the TEP Programme, please visit https://thesgc.org/tep
DOI: 10.7910/dvn/ve6vsr/zokbxg
title: two_arm_simulated_data.tab

description: :unav
DOI: 10.17632/mfw96cbgp4.1
title: ElectronDiffraction tools, a DigitalMicrograph package for electron diffraction analysis

description: Microstructure analysis based on the electron diffraction patterns (ED or SAED) or high-resolution transmission electron microscopy images (HRTEM) has become a major technique for the local structural characterization of materials. Three traditional methods of electron diffraction analysis are pattern indexing, phase identification, and unit cell determination. But for the lack of analysis tools, most of the people usually manually measure the diffraction spots to index the diffraction pattern or measure a few lattice planes (fringes in HRTEM or diffraction rings) to perform phase analysis. For the need of the daily-used diffraction analysis, we present a new processing & analysis package for electron diffraction pattern, ElectronDiffraction tools. The program was written as a package of DigitalMicrograph, a very popular software to record and analyze the data of transmission electron microscopes (TEM). Autocorrelation and digital filter method were implanted in it to yield a high-quality Fourier transform diffractogram from an HRTEM image, Gaussian filter and Gaussian fitting were applied to locate diffraction spots with sub-pixel accuracy. It can automatically measure diffraction spots to index the spotty-like diffraction pattern of the known crystal; intensity profile or surface plot extracted from a diffraction pattern can be used to carry out phase analysis just like ‘Search-Match’ in XRD, and the extracted d-spacing table can be used to determine the unit cell of the unknown crystal.
DOI: 10.17632/5pmrkmc2ks.1
title: Explaining the electoral success of the extreme right party ĽSNS in Slovakia 2010 - 2018: integration of Census data and electoral results

description: The unit of datais the so-called micro-region. These units were created in 2005 as an alternative to the existing territorial division of Slovakia (Slavík, Kožuch, and Bačík 2005) as group of municipalities following natural borders, as well as the economic and social structure of the population. Together there are 160 micro-regions with an average population of just over 30,000 people. However, two of the regions, which include the two biggest cities in Slovakia, the capital Bratislava, and the city of Košice, are enormously populated when compared to the other units. For the sake of the research, we divided these two regions into smaller parts, which we broke down into districts. As such, we work with 169 micro-regions. Finally, we excluded micro-regions with at least 30 percent Hungarians. Thus, we end up with 136 territorial units. Based on theoretical considerations, we need variables that capture the presence and share of Roma minority, unemployment and education. As the basis for analysis, we use census data and official results of national elections provided by the Slovak Statistical Office. Due to specific conditions, the data about the Roma minority are gathered from the Atlas project . This unique project was undertaken in cooperation with several national and international bodies, and its results are based on thorough fieldwork, mapping all towns in Slovakia. It tallies not only the numbers of persons belonging to the Roma minority, but it also describes how Roma people are concentrated in a municipality. The remaining variables are based on census data. Unemployment rate is computed as the share of unemployed people among all economically active people. For the measure of education, we use a variable of the share of people with vocational education, because the proportion of people with basic education as the lowest possible level strongly correlates with unemployment. The amount of people with vocational education is calculated as the share of those with this level of education among all inhabitants older than fifteen years of age. Dependent variable of analysis is the support of LSNS in microregions computed from official electoral results of 2010, 2012 and 2016 elections.
DOI: 10.17632/m25gychnpk.1
title: Data for: Does oil price uncertainty affect renewable energy investment? Evidence from listed firms in China
DOI: 10.17632/sy58zbv3s2.1
title: DAISIE objects used for the global analysis of island birds
DOI: 10.17632/d9yv85vxbz.2
title: Data for: Staff rotation as an anti-corruption policy in China and in Germany: an experimental comparison

description: Raw data of experiment in China and Germany
DOI: 10.17632/vgdnf8z3s5.1
title: Data for: Is There No “I” in “Team”? Interindividual-Intergroup Discontinuity Effect in a Cournot Competition Experiment

description: Abstract of associated article: Even though firms consist of teams of individuals, industrial organization experiments are typically conducted under the unitary player assumption with individuals representing firms. Against this practice, there is evidence that individuals' decisions differ from those made by teams, and also from individuals' decisions which affect both oneself and others. This study examines the empirical scope of the unitary player assumption (alternatively the ``interindividual-intergroup discontinuity effect'') in the context of a Cournot competition experiment. In the first, standard, experiment (216 participants), we find no evidence for the discontinuity effect. Output choices of both individuals and teams are around the Cournot outcome. In a second experiment (198 participants), we use a recommendation to shift participants' initial disposition towards the (off-equilibrium) collusive output. This triggers the discontinuity effect; individuals choose lower outputs and collude more than teams. This effect is persistent in the second half of the experiment, and is not caused by team-member discussion or by seating team members together. We discuss the interpretations and implications of our results.
DOI: 10.17632/jkpb3zgw53.1
title: Data from: Financial performance of sustainable investments in global stock markets

description: Supporting information related to the manuscript “Financial performance of sustainable investments in global stock markets”, submitted in June 2019 to Business Strategy and the Environment. The “Supporting information (database).xlsx” file summarizes the manuscript related data and provides step-by-step procedures to collect the original series and make the necessary transformations for subsequent (financial performance) analysis. The database comprises daily US$ prices of five sustainability indices (and of five market portfolios, used as benchmarks for the sustainability indices) and the risk-free rate, represented by the 4-week US Treasury bill (T-bill) rate, from January 1st 2013 to December 31st 2018. The file also provides the probabilities of the assessed indices’ returns falling between -1.0% and 1.0%, as discussed in Section 4.2 of the manuscript. The “Supporting information (literature overview).docx” file summarizes important information from the most recent and/or cited studies related to the performance of sustainability indices, based on queries on Scopus and Web of Science databases.
DOI: 10.17632/zr389h28zn.1
title: 2. Data from: “Learning to run over-ground with less tibial shock: change point discovery”

description: This dataset contains the time series of axial peak tibial acceleration for 10 runners with high tibial shock. The participants performed a running retraining session with real-time auditory biofeedback on axial peak tibial acceleration (cf. tibial shock) at an indoor track and field site at 3.2 ± 0.2 m/s in self-selected footwear. The axial peak tibial acceleration was detected before and during the biofeedback-based intervention using a backpack system connected to a very lightweight accelerometer. Please see the full paper for details on how the data were collected and processed. Data are from an experimental protocol approved by the Ethics Committee of Ghent University (bimetra identification number 2015/0864).
DOI: 10.5281/zenodo.3243267
title: Patients data for meta-analysis of genotype-phenotype associations in Bardet-Biedl Syndrome

description: Data used for metaanalysis of the genotype-phenotype relationship in Bardet Biedl Syndrome.

File "EV table 1 literature.xlsx" describes studies that were included in the metaanalysis. File "EV table 2 dataset.xlsx" contains individual patient data. Each row corresponds to a patient. If the same patient was reported in more than 1 study, their data were merged into one row. The columns are as follows:

* source - a citation to the study the patient originated in

* FamilyID - randomly generated ID of a family (unique over the dataset), two persons with the same FamilyID are related.

* source case n. - A unique identifier of the patient within the study

* gene - A gene carrying the principal BBSome related mutation

* nucleotide change (allele 1,2)  - description of the mutations in DNA individual alleles of the gene, in HGVS nomenclature

* protein change (allele 1,2)  - description of how the mutations in DNA change the resulting protein, in HGVS nomenclature

* type of mut allele 1,2 - whether the given mutation  is considered missense (MS) or large truncation (trunc)

* mut/mut - combination of mutations for both alleles

* additional mutations - mutations in other BBSome-related genes. Format is "gene: DNA mutation, protein mutation"

* sex - "F" or "M"  (where reported)

* age group - age group (where reported)

* age - age in years. Contains fractions, decimal values and "5 month"

* RD, OBE, PD, CI, REP, REN, HEART, LIV, DD - presense or absence of phenotypes, if reported. RD – retinal dystrophy, OBE – obesity, PD – polydactyly, CI – cognitive impairment , REP – reproductive system anomalies, REN – renal anomalies, HRT – heart disease, LIV – liver anomalies, DD - Developmental delay. Values are "" (not reported), "0" (no phenotype), "1" (phenotype present), "1!" conflicting reports of phenotype in multiple studies (some patients were involved in multiple studies)

* ethnicity - ethnicity of the patient, if reported

* ethinc group - grouping of the ethnicities into 8 larger groups (see paper for details)

* note - miscellanous text, in particular contains notes on patients merged from multiple studies

====

The protocol for this meta-analysis was pre-registered with PROSPERO (CRD42018096099).

PubMed and Google Scholar databases were searched in May 2018 for the following keywords: [bardet-biedl syndrome AND (genotype phenotype OR cohort)]. Other suitable records were identified by snowball searching, in particular, by retrieving relevant articles from the references of the studied full-texts. In addition, all the references included in the publicly available Euro-Wabb database (https://lovd.euro-wabb.org/home.php) were covered. Our search was limited to the literature published in English language and covered the period from the inception of each database to the 21st of May 2018.
DOI: 10.5281/zenodo.3245550
title: EMAG2: Earth Magnetic Anomaly Grid (2-arc-minute resolution) compressed for NumPy

description: A compressed NumPy version of the EMAG2 (v3) global Earth Magnetic anomaly grid compiled from satellite, ship, and airborne magnetic measurements. The original CSV data was imported, transformed, and saved to a compressed NumPy archive as follows:

<pre><code class="language-python">import numpy as np

mag_data = np.loadtxt('EMAG2_V3_20170530.csv', delimiter=',', usecols=(2,3,4,5,7))
lon_mask = mag_data[:,0] &gt; 180.0
mag_data[lon_mask,0] -= 360.0
np.savez_compressed('EMAG2_V3_20170530.npz', data=mag_data.astype(np.float32))</code></pre>

The NumPy archive (contained in this repository) can be efficiently loaded in Python workflows. It contains the following columns:


	Longitude - geographic longitudinal coordinates in decimal degrees (WGS84)
	Latitude - geographic latitudinal coordinates in decimal degrees (WGS84)
	SeaLevel - magnetic anomaly value at sea level (nT)
	UpCont - magnetic anomaly value at continuous 4km altitude (nT)
	Error - Error estimate (nT)


Code 888 is assigned in certain cells on grid edges where the data source is ambiguous and assigned an error of -888 nT.<br>
Code 999 is assigned in cells where no data is reported with the anomaly value assigned 99999 nT and an error of -999 nT.

<strong>Reference</strong>

Brian Meyer, Richard Saltus, Arnaud Chulliat (2017): EMAG2: Earth Magnetic Anomaly Grid (2-arc-minute resolution) Version 3. National Centers for Environmental Information, NOAA. Model. doi:10.7289/V5H70CVX
DOI: 10.5281/zenodo.3245551
title: EMAG2: Earth Magnetic Anomaly Grid (2-arc-minute resolution) compressed for NumPy

description: A compressed NumPy version of the EMAG2 (v3) global Earth Magnetic anomaly grid compiled from satellite, ship, and airborne magnetic measurements. The original CSV data was imported, transformed, and saved to a compressed NumPy archive as follows:

<pre><code class="language-python">import numpy as np

mag_data = np.loadtxt('EMAG2_V3_20170530.csv', delimiter=',', usecols=(2,3,4,5,7))
lon_mask = mag_data[:,0] &gt; 180.0
mag_data[lon_mask,0] -= 360.0
np.savez_compressed('EMAG2_V3_20170530.npz', data=mag_data.astype(np.float32))</code></pre>

The NumPy archive (contained in this repository) can be efficiently loaded in Python workflows. It contains the following columns:


	Longitude - geographic longitudinal coordinates in decimal degrees (WGS84)
	Latitude - geographic latitudinal coordinates in decimal degrees (WGS84)
	SeaLevel - magnetic anomaly value at sea level (nT)
	UpCont - magnetic anomaly value at continuous 4km altitude (nT)
	Error - Error estimate (nT)


Code 888 is assigned in certain cells on grid edges where the data source is ambiguous and assigned an error of -888 nT.<br>
Code 999 is assigned in cells where no data is reported with the anomaly value assigned 99999 nT and an error of -999 nT.

<strong>Reference</strong>

Brian Meyer, Richard Saltus, Arnaud Chulliat (2017): EMAG2: Earth Magnetic Anomaly Grid (2-arc-minute resolution) Version 3. National Centers for Environmental Information, NOAA. Model. doi:10.7289/V5H70CVX
DOI: 10.17632/vh26vyn29x.1
title: Data for: Comparative Analysis of Rapid Equilibrium Dialysis (RED) and Solid Phase Micro-Extraction (SPME) Methods for In Vitro-In Vivo Extrapolation of Environmental Chemicals

description: Protein binding free fraction measured by rapid equilibrium dialysis and by solid phase micro extraction.
DOI: 10.17632/w2678cnzsg.1
title: Alcohool oxidation performance of TiO2 added polyvinylidene fluoride (PVDF) membrane at microwave conditions

description: Catalytic membrane reactors are materials on that fine chemical synthesis and pollution degradation could be done during the filtration. These systems could be commanly controlled by UV, heat and infrared radiation. In this study, materials designed for microwave radiation controlled system, and their performances for benzyl alcohool oxidation were tested at batch reactor. Interaction of TiO2 added PVDF flat sheets (membranes) prepared by phase inversion method with microwave radiation was firstly investigated. FTIR, TG-DTA and SEM analysis with contact angle measurements were conducted.Interaction between TiO2 and PVDF chain was evidenced by 1550 and 1629 cm-1 bands. TiO2 added PVDF membranes had improved filtration and rejection performance. 32.4% BSA rejection was obtained with composites while it was 7.5% of pristine membrane. 93.86% conversion and 56% selectivity were obtained with composites in microwave assisted batch reactor. Decomposition of polymer increased when 6% additive due to catalytic effect of TiO2 then, it decreased with further loading. Detailed evidences were obtained by activation energies (Ea) of decomposition calculated by Kissinger method. Microwave assisted catalytic effect of TiO2 inside polymeric matrix promise to obtain fast, high yielded and disposable membrane materials for catalytic reactors to in-situ production of fine chemicals.