DOI: 10.5061/dryad.qv9s4mwp2
title: Data from: Clinical scores before and after multi-nodal DBS

description: Background Mixed and complex movement disorders represent significant
 challenges for surgical treatment. These disease states are likely the
 result of combined or complex network pathologies affecting multiple
 pathways1-4. Until recently, attempts to treat complex movement disorders
 with deep brain stimulation (DBS) have primarily focused on stimulating a
 single deep target to address patients’ most severe symptoms5-14. However,
 a multi-nodal targeting approach for DBS by simultaneously stimulating
 more than one pair of homologous nuclei could be a more effective
 treatment strategy. Here, we present the technique and initial case series
 of utilizing multi-nodal stimulation for mixed and complex movement
 disorders. Methods An initial cohort of fifteen mixed and complex movement
 disorder patients presenting to Stanford University underwent a
 multi-nodal stimulation approach. In these patients, the multiple (i.e.
 &gt; 2) simultaneous deep targets were implanted through only 2 burr
 holes and connected to a single 32-channel pulse generator. Results There
 were no intra- or post-operative complications. With the addition of
 multi-nodal stimulation, complex PD patients demonstrated a significant
 reduction in Unified Parkinson’s Disease Rating Scale (p = 0.0039) and
 complex tremor patients demonstrated a significant reduction in Clinical
 Rating Scale for Tremor (p = 0.0312). Conclusion We present the largest
 initial case series demonstrating the safety, feasibility, and added
 efficacy of single system multi-nodal DBS for treating mixed and complex
 movement disorders. This approach is safe, provides additional benefit,
 and warrants further investigation for treating mixed and complex movement
 disorders.
description: An initial cohort of fifteen mixed and complex movement disorder
 patients presenting to Stanford University underwent a multi-nodal
 stimulation approach. In these patients, the multiple (i.e. &gt; 2)
 simultaneous deep targets were implanted through only 2 burr holes and
 connected to a single 32-channel pulse generator. Clinical scores
 including Unified Parkinson's Disease Rating Scale (UPDRS) and
 Clinical Rating Scale for Tremor (CRST) were taken from chart review of
 visits before and after surgery.
description: # **Utilizing Multi-nodal Deep Brain Stimulation for Treatment of Complex
 Movement Disorders: Clinical Scores Before and After Surgery**
 [https://doi.org/10.5061/dryad.qv9s4mwp2](https://doi.org/10.5061/dryad.qv9s4mwp2) Fifteen patients were assessed before and after implantation of 3-4 directional deep brain stimulation leads targeting two (usually bilateral) distinct nuclei to address multiple dominant movement disorder symptoms. Clinical scores from before and after implantation were conducted by licensed physicians in clinic and pulled from patient charts. ## Description of the data and file structure Here we include a tabulation of the clinical scores recorded from before and after implantation, these being Unified Parkinson's Disease Rating Scale (UPDRS) and Clinical Rating Scale for Tremor (CRST). These are marked respectively for each patient. Also included are the patients' unique identifiers, sex, movement disorder diagnoses, and DBS targets corresponding to "Utilizing Multi-nodal Deep Brain Stimulation for Treatment of Complex Movement Disorders: Initial Case Series."   ## Code/Software Python script used to construct violin plots and compute significance. Some modification required when computing separate groups/subgroups. Primarily, input the values of interest into the CSV file referenced in the script, and comment out or in UPDS/CRST respectively if you wish to only calculate significance for one group or subgroup.