cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.7591598.v1
title: Use of Coconut Charcoal and Menthone-Thiosemicarbazone Polymer as Solid Phase Materials for the Determination of N,N-Dimethyltryptamine, Harmine, Harmaline, Harmalol, and Tetrahydroharmine in Ayahuasca Beverage by Liquid Chromatography-Tandem Mass Spectrometry

description: An extraction method based on solid-phase extraction was developed to determine the major alkaloid components, N,N-dimethyltryptamine, harmine, harmaline, harmalol, and tetrahydroharmine, in ayahuasca using ultra-performance liquid chromatography-tandem mass spectrometry. Coconut charcoal and menthone-thiosemicarbazone polymer were tested as new adsorbent materials. Experiments carried out at levels of 1, 5, 10, 50, 100, and 250 µg mL-1 resulted in recoveries in the ranges 45.3-115.7% for menthone-thiosemicarbazone and 40.6-116.2% for coconut charcoal. The detection and quantification limits ranged from 0.003 to 0.016 µg mL-1 and from 0.009 to 0.043 µg mL-1, respectively. The method developed was linear over the tested range (0.05-1.0 µg mL-1), with correlation coefficients ranging from 0.9969 to 0.9998. The technique was applied for analysis of the compounds in an ayahuasca sample collected from a religious group located in the city of Fortaleza, obtaining concentrations in the range from 0.3 to 19.3 mg mL-1.
DOI: 10.6084/m9.figshare.7591589
title: Determination of Parabens in Breast Milk Samples by Dispersive Liquid-Liquid Microextraction (DLLME) and Ultra-High-Performance Liquid Chromatography Tandem Mass Spectrometry

description: A reliable method was developed and validated based on dispersive liquid-liquid microextraction (DLLME) and ultra-high-performance liquid chromatography coupled to tandem mass spectrometry (UHPLC-MS/MS) to determine simultaneously methylparaben (MePB), ethylparaben (EtPB), propylparaben (PrPB), and butylparaben (BuPB) in breast milk samples. A central composite design 24 with four independent variables and five levels of variance was used to optimize the DLLME conditions. The DLLME/UHPLC-MS/MS method was linear from 5 (lower limit of quantification, LLOQ) to 100 ng mL-1 (upper limit of quantification, ULOQ). The inter-assay and intra-assay precision values presented coefficients of variation (CVs) lower than 15%, and the relative standard error of the inter- and intra-assay accuracy values was lower than 10.4%. The DLLME/UHPLC-MS/MS method was successfully applied to determine parabens in human milk samples obtained from sixteen volunteer lactating mothers.
DOI: 10.6084/m9.figshare.7591592.v1
title: Influence of Diffusion Parameters on Electrical Characteristics of mc-Si Solar Cells with Aluminum and Phosphorus Diffusion Performed in the Same Thermal Step

description: The diffusion of phosphorus and aluminum in a single-step thermal process may reduce the production cost of multicrystalline silicon (mc-Si) solar cells. The goal of this paper is to analyze the influence of phosphorus diffusion parameters on the electrical characteristics of p-type mc-Si solar cells processed with a single-step diffusion of phosphorus and aluminum. To avoid the wafer bowing during aluminum paste firing, the aluminum was deposited by e-beam and co-diffused in the same thermal step that the phosphorus diffusion. First, the aluminum diffusion was performed and, then, the POCl3 was introduced into the quartz tube. The steps of the phosphorus diffusion were experimentally optimized. The best result was found with the temperature of 875 ºC. The POCl3 concentration of 0.15 % and the optimized phosphorus diffusion parameters lead to the efficiency of 14.1%. The reduction of the oxygen flow during ramp temperature and aluminum diffusion improved the efficiency.
DOI: 10.7284/115578
title: CTD (Conductivity, Temperature, Depth) data collected during research cruise FK140307 using a Sea-Bird SBE-911+ instrument system onboard the platform RV Falkor

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7591583
title: Turner syndrome and spontaneous pregnancy

description: ABSTRACT The objective of this study is to describe patients with Turner syndrome (TS) who had spontaneous pregnancy and, when possible, to present the frequency of this outcome in this genetic condition. This is a literature review conducted in MedLine/PubMed, using the following English descriptors: Turner syndrome and spontaneous pregnancy. The following filters have been activated: articles with a publication date from the last 10 years that present the descriptors in the title/abstract. Twenty-nine articles were identified using the electronic search. After applying the inclusion and exclusion criteria, the number of articles selected was seven. However, two more articles were included after consulting the reference lists of these seven studies, totaling nine scientific articles. The frequency of spontaneous pregnancy ranged from 1.26% to 5.6%. Sixty-two TS patients who spontaneously became pregnant and 153 pregnancies were reported. There was a predominance of karyotype 45,X/46,XX (42 patients). Three patients were diagnosed with TS in adulthood and two of them after pregnancy. The minimum age at pregnancy was 21 years and the maximum 32. In the gestational outcome, an expressive number of children born, and abortions were observed, the latter with values of 54.9% and 34.6%. The present study described patients with TS and spontaneous pregnancy with mosaic (more frequent) and pure karyotype. It is believed that this value may be underestimated, since few studies have investigated primarily spontaneous pregnancy in this genetic condition, and many TS patients may not have been diagnosed because of the wide phenotypic variability associated with this chromosomal abnormality.
DOI: 10.6084/m9.figshare.7591586
title: Anti-Parasite Activity of Novel 3,5-Diiodophenethyl-benzamides

description: Novel iodotyramides with para-substituted benzoic acids were synthesized via electrophilic aromatic substitutions and amide coupling via N,N'-diisopropylcarbodiimide (DIC) in dimethylformamide (DMF). All derivatives were in vitro screened against U-937 macrophages and Plasmodium falciparum, Leishmania panamensis and Trypanosoma cruzi protozoan parasites. The hemolytic activity was evaluated on human red blood cells (RBC). Compounds N-(4-hydroxy-3,5-diiodophenethyl)-4-methylbenzamide and N-(3,5-diiodo-4-methoxyphenethyl)-4-methoxybenzamide were the most active against L. panamensis with an effective concentration 50 (EC50) of 17.9 and 17.5 µg mL-1, respectively; while compounds N-(3,5-diiodo-4-methoxyphenethyl)-4-methylbenzamide and N-(3,5-diiodo-4-methoxyphenethyl)-4-methoxybenzamide were the most active for T. cruzi with EC50 values of 23.75 and 6.19 µg mL-1, respectively. In contrast, all derivatives showed high activity against P. falciparum with EC50 &lt; 25 µg mL-1, except compound N-(4-hydroxy-3,5-diiodophenethyl)-benzamide. No compound was hemolytic over RBC. This report represents the importance of novel iodotyramides as anti-parasites agents.
DOI: 10.6084/m9.figshare.7591589.v1
title: Determination of Parabens in Breast Milk Samples by Dispersive Liquid-Liquid Microextraction (DLLME) and Ultra-High-Performance Liquid Chromatography Tandem Mass Spectrometry

description: A reliable method was developed and validated based on dispersive liquid-liquid microextraction (DLLME) and ultra-high-performance liquid chromatography coupled to tandem mass spectrometry (UHPLC-MS/MS) to determine simultaneously methylparaben (MePB), ethylparaben (EtPB), propylparaben (PrPB), and butylparaben (BuPB) in breast milk samples. A central composite design 24 with four independent variables and five levels of variance was used to optimize the DLLME conditions. The DLLME/UHPLC-MS/MS method was linear from 5 (lower limit of quantification, LLOQ) to 100 ng mL-1 (upper limit of quantification, ULOQ). The inter-assay and intra-assay precision values presented coefficients of variation (CVs) lower than 15%, and the relative standard error of the inter- and intra-assay accuracy values was lower than 10.4%. The DLLME/UHPLC-MS/MS method was successfully applied to determine parabens in human milk samples obtained from sixteen volunteer lactating mothers.
DOI: 10.6084/m9.figshare.7591577
title: Impact of Communication Skills Training and Medical Records in the Practice of Patient-Centered Care

description: ABSTRACT Introduction The practice of comprehensive clinical care of the individual is a challenge faced by medical educators, educational institutions, and researchers seeking to contribute to the development of students’ educational skills that combine knowledge, skills and attitudes for this model. Objective To evaluate the impact of communication skills training in the practice of the clinical method of comprehensive clinical care, with or without the use of a specific medical record. Methods Forty-six students in the 7th Period of medical school participated in the study. A combination of educational activities was used to facilitate the acquisition of communication skills for comprehensive clinical care, including: a modeling example, followed by individual reflection and discussion, an interactive lecture, and the use of a specific medical appointment for comprehensive clinical care of the individual (RACIP). The study was divided into four Phases: Phase 1 − Pre-training: filming of clinical care in a simulated environment, carried out by the 46 students, using the current medical appointment in the HC-UFMG. Phase 2 − Training: students were divided into three groups: G1: performed an educational activity not related to clinical care; G2 and G3: received communication skills training. Phase 3 − Evaluation: filming of a consultation in a simulated environment, performed by all the groups, with G1 and G3 using RACIP, and G2, the current medical appointment model. Phase 4 − Feedback and learning opportunity for all the groups. The videos of the clinic visits performed by the students, pre- and post-training, were evaluated by a panel consisting of three evaluators, using the AVACIP instrument (evaluation of comprehensive clinical care of the individual). This takes into account five domains: the initial approach to the consultation; the patient’s expectations; the patient’s perspective of his/her illness; behavior and lifestyle habits; use of complementary propaedeutic and therapeutic alliance. Results The total positive attitude score for each group was higher in Phase 3 than in Phase 1 (p = 0.001), showing that all the strategies promoted an improvement in communication skills, but there were no differences between groups in each phase (p &gt; 0.310). Analyzing the scores by domain, it was observed that G3 performed better than the others. Conclusion The communication skills training and the use of the RACIP improved the students’ performance in relation to comprehensive clinical care of the individual.
DOI: 10.6084/m9.figshare.7591580
title: Factors Associated with Continued Smoking Addiction and Alcohol Consumption among Medical Students in Capital City in the Northeast of Brazil

description: ABSTRACT Introduction Drug use among young people in Brazil is increasing, particularly among the university students, leading to additional health-related concerns for students. Objective To identify factors associated with continued smoking addiction and alcohol consumption among medical students. Methods An analytical, prevalence study was carried out involving medical students at the four medical schools of Fortaleza, northeastern Brazil. A semi-structured questionnaire with 46 objective questions was applied to students in their first year of the course (S1/S2) in 2012 and again in 2016, when these same students were taking their internship (I3/I4). The sample was calculated based on a study population consisting of all the students in the two periods evaluated. The project was approved by the REC, through opinion no. 020/2012. Results 360 students were interviewed in the first phase of the research, and 354 students in the second phase. Tobacco consumption increased from 17.4% during the first year of the course to 28.2% during the internship (p &lt;0.001). The same occurred with alcohol consumption, which was already high at the beginning of the course (84.6%) and increased to 92.6% (p &lt;0.001). In the first year of the course, 40.5% of the students reported having got drunk at least once. During their time at medical school, this percentage rose to 59.5% (PR = 1.66, p &lt;0.001). Conclusion Alcohol and tobacco consumption increased significantly during medical school. There is a need for interventions in the habits of medical student, in order to reduce excessive alcohol consumption and smoking in this population.
DOI: 10.6084/m9.figshare.7591580.v1
title: Factors Associated with Continued Smoking Addiction and Alcohol Consumption among Medical Students in Capital City in the Northeast of Brazil

description: ABSTRACT Introduction Drug use among young people in Brazil is increasing, particularly among the university students, leading to additional health-related concerns for students. Objective To identify factors associated with continued smoking addiction and alcohol consumption among medical students. Methods An analytical, prevalence study was carried out involving medical students at the four medical schools of Fortaleza, northeastern Brazil. A semi-structured questionnaire with 46 objective questions was applied to students in their first year of the course (S1/S2) in 2012 and again in 2016, when these same students were taking their internship (I3/I4). The sample was calculated based on a study population consisting of all the students in the two periods evaluated. The project was approved by the REC, through opinion no. 020/2012. Results 360 students were interviewed in the first phase of the research, and 354 students in the second phase. Tobacco consumption increased from 17.4% during the first year of the course to 28.2% during the internship (p &lt;0.001). The same occurred with alcohol consumption, which was already high at the beginning of the course (84.6%) and increased to 92.6% (p &lt;0.001). In the first year of the course, 40.5% of the students reported having got drunk at least once. During their time at medical school, this percentage rose to 59.5% (PR = 1.66, p &lt;0.001). Conclusion Alcohol and tobacco consumption increased significantly during medical school. There is a need for interventions in the habits of medical student, in order to reduce excessive alcohol consumption and smoking in this population.
DOI: 10.6084/m9.figshare.7591583.v1
title: Turner syndrome and spontaneous pregnancy

description: ABSTRACT The objective of this study is to describe patients with Turner syndrome (TS) who had spontaneous pregnancy and, when possible, to present the frequency of this outcome in this genetic condition. This is a literature review conducted in MedLine/PubMed, using the following English descriptors: Turner syndrome and spontaneous pregnancy. The following filters have been activated: articles with a publication date from the last 10 years that present the descriptors in the title/abstract. Twenty-nine articles were identified using the electronic search. After applying the inclusion and exclusion criteria, the number of articles selected was seven. However, two more articles were included after consulting the reference lists of these seven studies, totaling nine scientific articles. The frequency of spontaneous pregnancy ranged from 1.26% to 5.6%. Sixty-two TS patients who spontaneously became pregnant and 153 pregnancies were reported. There was a predominance of karyotype 45,X/46,XX (42 patients). Three patients were diagnosed with TS in adulthood and two of them after pregnancy. The minimum age at pregnancy was 21 years and the maximum 32. In the gestational outcome, an expressive number of children born, and abortions were observed, the latter with values of 54.9% and 34.6%. The present study described patients with TS and spontaneous pregnancy with mosaic (more frequent) and pure karyotype. It is believed that this value may be underestimated, since few studies have investigated primarily spontaneous pregnancy in this genetic condition, and many TS patients may not have been diagnosed because of the wide phenotypic variability associated with this chromosomal abnormality.
DOI: 10.6084/m9.figshare.7591586.v1
title: Anti-Parasite Activity of Novel 3,5-Diiodophenethyl-benzamides

description: Novel iodotyramides with para-substituted benzoic acids were synthesized via electrophilic aromatic substitutions and amide coupling via N,N'-diisopropylcarbodiimide (DIC) in dimethylformamide (DMF). All derivatives were in vitro screened against U-937 macrophages and Plasmodium falciparum, Leishmania panamensis and Trypanosoma cruzi protozoan parasites. The hemolytic activity was evaluated on human red blood cells (RBC). Compounds N-(4-hydroxy-3,5-diiodophenethyl)-4-methylbenzamide and N-(3,5-diiodo-4-methoxyphenethyl)-4-methoxybenzamide were the most active against L. panamensis with an effective concentration 50 (EC50) of 17.9 and 17.5 µg mL-1, respectively; while compounds N-(3,5-diiodo-4-methoxyphenethyl)-4-methylbenzamide and N-(3,5-diiodo-4-methoxyphenethyl)-4-methoxybenzamide were the most active for T. cruzi with EC50 values of 23.75 and 6.19 µg mL-1, respectively. In contrast, all derivatives showed high activity against P. falciparum with EC50 &lt; 25 µg mL-1, except compound N-(4-hydroxy-3,5-diiodophenethyl)-benzamide. No compound was hemolytic over RBC. This report represents the importance of novel iodotyramides as anti-parasites agents.
DOI: 10.7284/115730
title: Expendable Probe data collected during research cruise FK140307 using a Turo Quoll instrument system onboard the platform RV Falkor

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7591577.v1
title: Impact of Communication Skills Training and Medical Records in the Practice of Patient-Centered Care

description: ABSTRACT Introduction The practice of comprehensive clinical care of the individual is a challenge faced by medical educators, educational institutions, and researchers seeking to contribute to the development of students’ educational skills that combine knowledge, skills and attitudes for this model. Objective To evaluate the impact of communication skills training in the practice of the clinical method of comprehensive clinical care, with or without the use of a specific medical record. Methods Forty-six students in the 7th Period of medical school participated in the study. A combination of educational activities was used to facilitate the acquisition of communication skills for comprehensive clinical care, including: a modeling example, followed by individual reflection and discussion, an interactive lecture, and the use of a specific medical appointment for comprehensive clinical care of the individual (RACIP). The study was divided into four Phases: Phase 1 − Pre-training: filming of clinical care in a simulated environment, carried out by the 46 students, using the current medical appointment in the HC-UFMG. Phase 2 − Training: students were divided into three groups: G1: performed an educational activity not related to clinical care; G2 and G3: received communication skills training. Phase 3 − Evaluation: filming of a consultation in a simulated environment, performed by all the groups, with G1 and G3 using RACIP, and G2, the current medical appointment model. Phase 4 − Feedback and learning opportunity for all the groups. The videos of the clinic visits performed by the students, pre- and post-training, were evaluated by a panel consisting of three evaluators, using the AVACIP instrument (evaluation of comprehensive clinical care of the individual). This takes into account five domains: the initial approach to the consultation; the patient’s expectations; the patient’s perspective of his/her illness; behavior and lifestyle habits; use of complementary propaedeutic and therapeutic alliance. Results The total positive attitude score for each group was higher in Phase 3 than in Phase 1 (p = 0.001), showing that all the strategies promoted an improvement in communication skills, but there were no differences between groups in each phase (p &gt; 0.310). Analyzing the scores by domain, it was observed that G3 performed better than the others. Conclusion The communication skills training and the use of the RACIP improved the students’ performance in relation to comprehensive clinical care of the individual.
DOI: 10.6084/m9.figshare.7591562
title: Population density of Arabica coffee cultivars for bean quality and yield

description: ABSTRACT For the implantation of a coffee tree crop, aiming at a high yield, each cultivar, depending on the plant distribution and density, can express differently its results. This study aimed to evaluate the yield potential and grain quality of Arabica coffee cultivars grown under different spacings between rows and between plants. A randomized block design was used, with three replications, in a split-split-plot scheme, being the plots three coffee cultivars (Obatã IAC-1669-20, Tupi IAC-1669-33 and Catuaí Vermelho IAC-144), four spacings between rows (1.8 m, 2.0 m, 2.5 m and 3.0 m) and four spacings between plants in the row (0.5 m, 0.7 m, 0.8 m and 1.0 m), totaling 48 treatments. The type of coffee bean (flat, peaberry and elephant) and yield per hectare were evaluated. The Obatã cultivar showed the highest potential yield, in relation to Tupi and Catuaí Vermelho, and also the highest percentage of flat grains. The factors, in order of importance, that interfere with the potential yield of processed coffee are the cultivar and the spacing between rows and between plants.
DOI: 10.6084/m9.figshare.7591568
title: Image analysis of papaya seeds submitted to sarcotesta removal methods

description: ABSTRACT The germination of papaya seeds is slow and uneven, usually due to inhibitors present in the sarcotesta; however, some removal procedures may cause physical damage, negatively interfering in the physiological quality and field performance. This study aimed to evaluate the physical and physiological quality of papaya seeds submitted to methods of sarcotesta removal by image analysis. Papaya Formosa ‘Tainung 01' seeds were submitted to the following methods of sarcotesta removal: fermentation + sieve, sand + sieve, sieve and blender + sieve. After the sarcotesta removal, the seeds were submitted to tests of germination, first germination count, germination speed and seedling length. For the image analysis, the seeds without sarcotesta were submitted to the X-ray test and to a computerized analysis of seedling images by the SVIS® software. The methods used were only promising for the sarcotesta removal, while the blender + sieve method obtained the highest physical and physiological seed quality, in addition to performing the best sarcotesta removal. However, the image analysis using the SVIS® software allowed to identify the high physical and physiological seed quality using the blender + sieve method, which promoted the highest efficiency in removing the sarcotesta.