cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.5634385
title: Waist Circumference is Associated with Blood Pressure in Children with Normal Body Mass Index: A Cross-Sectional Analysis of 3,417 School Children

description: Abstract Background: The prevalence of childhood obesity and associated conditions, such as hypertension, has become a major problem of public health. Although waist circumference (WC) is a marker of cardiovascular risk in adults, it is unclear whether this index is associated with cardiovascular risk factors in children. Objective: Our aim was to evaluate the association between increased WC and elevated blood pressure (BP) in children with normal body mass index (BMI) ranges. Methods: Cross-sectional evaluation of students between 6 and 11 years with normal BMI. WC was categorized by quartile for each age group. Normal BP was defined as values &lt; 90th percentile, and levels above this range were considered elevated. Values of p &lt; 0.05 were considered statistically significant. Results: Of the 5,037 children initially assessed, 404 (8%) were excluded for being underweight and 1,216 (24.1%) were excluded for being overweight or obese. A final sample of 3,417 children was evaluated. The prevalence of elevated BP was 10.7%. In children with WC in the lowest quartile, the prevalence of elevated BP was 8.1%. This prevalence increased in upper quartiles: 10.6% in the second, 12.4% in third and 12.1% in the upper quartile. So, in this group, being in the highest WC quartile was associated with a 57% higher likelihood to present elevated BP when compared to those in the lowest quartile (Q4 vs Q1; OR 1.57 - 95%CI 1.14 - 2.17). Conclusion: In children aged 6 to 11 years, increased waist circumference is associated with elevated BP even when BMI is normal.
DOI: 10.6084/m9.figshare.5634385.v1
title: Waist Circumference is Associated with Blood Pressure in Children with Normal Body Mass Index: A Cross-Sectional Analysis of 3,417 School Children

description: Abstract Background: The prevalence of childhood obesity and associated conditions, such as hypertension, has become a major problem of public health. Although waist circumference (WC) is a marker of cardiovascular risk in adults, it is unclear whether this index is associated with cardiovascular risk factors in children. Objective: Our aim was to evaluate the association between increased WC and elevated blood pressure (BP) in children with normal body mass index (BMI) ranges. Methods: Cross-sectional evaluation of students between 6 and 11 years with normal BMI. WC was categorized by quartile for each age group. Normal BP was defined as values &lt; 90th percentile, and levels above this range were considered elevated. Values of p &lt; 0.05 were considered statistically significant. Results: Of the 5,037 children initially assessed, 404 (8%) were excluded for being underweight and 1,216 (24.1%) were excluded for being overweight or obese. A final sample of 3,417 children was evaluated. The prevalence of elevated BP was 10.7%. In children with WC in the lowest quartile, the prevalence of elevated BP was 8.1%. This prevalence increased in upper quartiles: 10.6% in the second, 12.4% in third and 12.1% in the upper quartile. So, in this group, being in the highest WC quartile was associated with a 57% higher likelihood to present elevated BP when compared to those in the lowest quartile (Q4 vs Q1; OR 1.57 - 95%CI 1.14 - 2.17). Conclusion: In children aged 6 to 11 years, increased waist circumference is associated with elevated BP even when BMI is normal.
DOI: 10.6084/m9.figshare.5634382
title: Predictors of Total Mortality and Echocardiographic Response for Cardiac Resynchronization Therapy: A Cohort Study

description: Abstract Background: Clinical studies demonstrate that up to 40% of patients do not respond to cardiac resynchronization therapy (CRT), thus, appropriate patient selection is critical to the success of CRT in heart failure. Objective: Evaluation of mortality predictors and response to CRT in the Brazilian scenario. Methods: Retrospective cohort study including patients submitted to CRT in a tertiary hospital in southern Brazil from 2008 to 2014. Survival was assessed through a database of the State Department of Health (RS). Predictors of echocardiographic response were evaluated using Poisson regression. Survival analysis was performed by Cox regression and Kaplan Meyer curves. A two-tailed p value less than 0.05 was considered statistically significant. Results: A total of 170 patients with an average follow-up of 1011 ± 632 days were included. The total mortality was 30%. The independent predictors of mortality were age (hazard ratio [HR] of 1.05, p = 0.027), previous acute myocardial infarction (AMI) (HR of 2.17, p = 0.049) and chronic obstructive pulmonary disease (COPD) (HR of 3.13, p = 0.015). The percentage of biventricular stimulation at 6 months was identified as protective factor of mortality ([HR] 0.97, p = 0.048). The independent predictors associated with the echocardiographic response were absence of mitral insufficiency, presence of left bundle branch block and percentage of biventricular stimulation. Conclusion: Mortality in patients submitted to CRT in a tertiary hospital was independently associated with age, presence of COPD and previous AMI. The percentage of biventricular pacing evaluated 6 months after resynchronizer implantation was independently associated with improved survival and echocardiographic response.
DOI: 10.6084/m9.figshare.5634382.v1
title: Predictors of Total Mortality and Echocardiographic Response for Cardiac Resynchronization Therapy: A Cohort Study

description: Abstract Background: Clinical studies demonstrate that up to 40% of patients do not respond to cardiac resynchronization therapy (CRT), thus, appropriate patient selection is critical to the success of CRT in heart failure. Objective: Evaluation of mortality predictors and response to CRT in the Brazilian scenario. Methods: Retrospective cohort study including patients submitted to CRT in a tertiary hospital in southern Brazil from 2008 to 2014. Survival was assessed through a database of the State Department of Health (RS). Predictors of echocardiographic response were evaluated using Poisson regression. Survival analysis was performed by Cox regression and Kaplan Meyer curves. A two-tailed p value less than 0.05 was considered statistically significant. Results: A total of 170 patients with an average follow-up of 1011 ± 632 days were included. The total mortality was 30%. The independent predictors of mortality were age (hazard ratio [HR] of 1.05, p = 0.027), previous acute myocardial infarction (AMI) (HR of 2.17, p = 0.049) and chronic obstructive pulmonary disease (COPD) (HR of 3.13, p = 0.015). The percentage of biventricular stimulation at 6 months was identified as protective factor of mortality ([HR] 0.97, p = 0.048). The independent predictors associated with the echocardiographic response were absence of mitral insufficiency, presence of left bundle branch block and percentage of biventricular stimulation. Conclusion: Mortality in patients submitted to CRT in a tertiary hospital was independently associated with age, presence of COPD and previous AMI. The percentage of biventricular pacing evaluated 6 months after resynchronizer implantation was independently associated with improved survival and echocardiographic response.
DOI: 10.6084/m9.figshare.5634379
title: Permanent Pacing After Transcatheter Aortic Valve Implantation: Incidence, Predictors and Evolution of Left Ventricular Function

description: Abstract Background: Transcatheter aortic valve implantation (TAVI) is a well-established procedure; however, atrioventricular block requiring permanent pacemaker implantation (PPI) is a common complication. Objectives: To determine the incidence, predictors and clinical outcomes of PPI after TAVI, focusing on how PPI affects left ventricular ejection fraction (LVEF) after TAVI. Methods: The Brazilian Multicenter TAVI Registry included 819 patients submitted to TAVI due to severe aortic stenosis from 22 centers from January/2008 to January/2015. After exclusions, the predictors of PPI were assessed in 670 patients by use of multivariate regression. Analysis of the ROC curve was used to measure the ability of the predictors; p &lt; 0.05 was the significance level adopted. Results: Within 30 days from TAVI, 135 patients (20.1%) required PPI. Those patients were older (82.5 vs. 81.1 years; p = 0.047) and mainly of the male sex (59.3% vs 45%; p = 0.003). Hospital length of stay was longer in patients submitted to PPI (mean = 15.7 ± 25.7 vs. 11.8 ± 22.9 days; p &lt; 0.001), but PPI affected neither all-cause death (26.7% vs. 25.6%; p = 0.80) nor cardiovascular death (14.1% vs. 14.8%; p = 0.84). By use of multivariate analysis, the previous presence of right bundle-branch block (RBBB) (OR, 6.19; 3.56-10.75; p ≤ 0.001), the use of CoreValve® prosthesis (OR, 3.16; 1.74-5.72; p ≤ 0.001) and baseline transaortic gradient &gt; 50 mm Hg (OR, 1.86; 1.08-3.2; p = 0.025) were predictors of PPI. The estimated risk of PPI ranged from 4%, when none of those predictors was present, to 63%, in the presence of all of them. The model showed good ability to predict the need for PPI: 0.69 (95%CI: 0.64 - 0.74) in the ROC curve. The substudy of 287 echocardiograms during the 1-year follow-up showed worse LVEF course in patients submitted to PPI (p = 0.01). Conclusion: BRD prévio, gradiente aórtico médio &gt; 50 mmHg e CoreValve® são preditores independentes de implante de MPD pós-TAVI. Ocorreu implante de MPD em aproximadamente 20% dos casos de TAVI, o que prolongou a internação hospitalar, mas não afetou a mortalidade. O implante de MPD afetou negativamente a FEVE pós-TAVI.
DOI: 10.6084/m9.figshare.5634379.v1
title: Permanent Pacing After Transcatheter Aortic Valve Implantation: Incidence, Predictors and Evolution of Left Ventricular Function

description: Abstract Background: Transcatheter aortic valve implantation (TAVI) is a well-established procedure; however, atrioventricular block requiring permanent pacemaker implantation (PPI) is a common complication. Objectives: To determine the incidence, predictors and clinical outcomes of PPI after TAVI, focusing on how PPI affects left ventricular ejection fraction (LVEF) after TAVI. Methods: The Brazilian Multicenter TAVI Registry included 819 patients submitted to TAVI due to severe aortic stenosis from 22 centers from January/2008 to January/2015. After exclusions, the predictors of PPI were assessed in 670 patients by use of multivariate regression. Analysis of the ROC curve was used to measure the ability of the predictors; p &lt; 0.05 was the significance level adopted. Results: Within 30 days from TAVI, 135 patients (20.1%) required PPI. Those patients were older (82.5 vs. 81.1 years; p = 0.047) and mainly of the male sex (59.3% vs 45%; p = 0.003). Hospital length of stay was longer in patients submitted to PPI (mean = 15.7 ± 25.7 vs. 11.8 ± 22.9 days; p &lt; 0.001), but PPI affected neither all-cause death (26.7% vs. 25.6%; p = 0.80) nor cardiovascular death (14.1% vs. 14.8%; p = 0.84). By use of multivariate analysis, the previous presence of right bundle-branch block (RBBB) (OR, 6.19; 3.56-10.75; p ≤ 0.001), the use of CoreValve® prosthesis (OR, 3.16; 1.74-5.72; p ≤ 0.001) and baseline transaortic gradient &gt; 50 mm Hg (OR, 1.86; 1.08-3.2; p = 0.025) were predictors of PPI. The estimated risk of PPI ranged from 4%, when none of those predictors was present, to 63%, in the presence of all of them. The model showed good ability to predict the need for PPI: 0.69 (95%CI: 0.64 - 0.74) in the ROC curve. The substudy of 287 echocardiograms during the 1-year follow-up showed worse LVEF course in patients submitted to PPI (p = 0.01). Conclusion: BRD prévio, gradiente aórtico médio &gt; 50 mmHg e CoreValve® são preditores independentes de implante de MPD pós-TAVI. Ocorreu implante de MPD em aproximadamente 20% dos casos de TAVI, o que prolongou a internação hospitalar, mas não afetou a mortalidade. O implante de MPD afetou negativamente a FEVE pós-TAVI.
DOI: 10.6084/m9.figshare.5634376
title: Chemical attributes of a remineralized Oxisol

description: ABSTRACT: Remineralizers are comminuted rocks that are applied to soil, and their use as an agricultural amendment was regulated in Brazil in 2013. However, mechanisms of action of these materials must be better known to enable them to be best used in agricultural fields. Soil chemical attributes of an Oxisol were monitored after the application of a diabase remineralizer. The increase in exchangeable Na observed was associated with the dissolution of the border of the plagioclase crystals where this element is highly concentrated (albite). Therefore, it was inferred that the time since the application of the remineralizer (1 to 2 years depending on the treatment) was not sufficient to exhaust this crystal volume. Unfortunately, the presence of several sources of Ca-containing minerals in the remineralizer did not allow to infer if the calcic nuclei was dissolving. An increase in effective cation exchange capacity was observed without the concurrent increase in the pH of the soil. The two non-exclusive hypotheses proposed to explain this result were that an extra surface charge has originated on the surface of the newly precipitated oxidic phases and/or from the dissolution of the remineralizer grains. Rapid precipitation of amorphous solids (as measured by the increase in Alo and Feo) would also explain the lack of increase in exchangeable Fe and Al despite the large amount of Al2O3 (11.90%) and Fe2O3 (14.45%) in the remineralizer.
DOI: 10.6084/m9.figshare.5634376.v1
title: Chemical attributes of a remineralized Oxisol

description: ABSTRACT: Remineralizers are comminuted rocks that are applied to soil, and their use as an agricultural amendment was regulated in Brazil in 2013. However, mechanisms of action of these materials must be better known to enable them to be best used in agricultural fields. Soil chemical attributes of an Oxisol were monitored after the application of a diabase remineralizer. The increase in exchangeable Na observed was associated with the dissolution of the border of the plagioclase crystals where this element is highly concentrated (albite). Therefore, it was inferred that the time since the application of the remineralizer (1 to 2 years depending on the treatment) was not sufficient to exhaust this crystal volume. Unfortunately, the presence of several sources of Ca-containing minerals in the remineralizer did not allow to infer if the calcic nuclei was dissolving. An increase in effective cation exchange capacity was observed without the concurrent increase in the pH of the soil. The two non-exclusive hypotheses proposed to explain this result were that an extra surface charge has originated on the surface of the newly precipitated oxidic phases and/or from the dissolution of the remineralizer grains. Rapid precipitation of amorphous solids (as measured by the increase in Alo and Feo) would also explain the lack of increase in exchangeable Fe and Al despite the large amount of Al2O3 (11.90%) and Fe2O3 (14.45%) in the remineralizer.
DOI: 10.6084/m9.figshare.5634373
title: Effect of shoot topping intensity on 'Cabernet Franc' grapevine maturity in high-altitude region

description: Abstract: The objective of this work was to evaluate the chemical composition of 'Cabernet Franc' grape subjected to different levels of shoot topping. The experiment was conducted in the 2008 and 2009 vintages, and the levels of shoot topping consisted of: control, without topping; and reductions of 15, 30, and 45% in total leaf area. The effect of shoot topping intensity on the chemical composition of the 'Cabernet Franc' grape berries was observed. A reduction of 26% in the vegetative canopy through a moderate shoot topping increased the total polyphenol index and the anthocyanin content. Shoot topping is a practice that must be carried out with caution, since severe shoot topping, i.e., a reduction greater than 26% of the leaf area, may negatively impact grape quality by reducing the content of soluble solids and decreasing the total polyphenol index and the content of anthocyanins of 'Cabernet Franc' grape berries.
DOI: 10.6084/m9.figshare.5634373.v1
title: Effect of shoot topping intensity on 'Cabernet Franc' grapevine maturity in high-altitude region

description: Abstract: The objective of this work was to evaluate the chemical composition of 'Cabernet Franc' grape subjected to different levels of shoot topping. The experiment was conducted in the 2008 and 2009 vintages, and the levels of shoot topping consisted of: control, without topping; and reductions of 15, 30, and 45% in total leaf area. The effect of shoot topping intensity on the chemical composition of the 'Cabernet Franc' grape berries was observed. A reduction of 26% in the vegetative canopy through a moderate shoot topping increased the total polyphenol index and the anthocyanin content. Shoot topping is a practice that must be carried out with caution, since severe shoot topping, i.e., a reduction greater than 26% of the leaf area, may negatively impact grape quality by reducing the content of soluble solids and decreasing the total polyphenol index and the content of anthocyanins of 'Cabernet Franc' grape berries.
DOI: 10.6084/m9.figshare.5634370
title: Effect of vacuum and oven drying on the radical scavenging activity and nutritional contents of submerged fermented Maitake (Grifola frondosa) mycelia

description: Abstract Maitake (Grifola frondosa) mycelia contain high dietary and medicinal values that have gained great attentions from consumers. Proper drying can preserve their bio-availabilities prior to subsequent processing or consumption. Pure Maitake (Grifola frondosa) strain was cultivated in Mushroom Complete Medium (MCM) using submerged fermentation for 14 days. Maitake mycelia were harvested and treated respectively by vacuum, oven drying treatments while the fresh mycelia were assigned as control. All the samples were tested for Total Phenolic Content, DPPH radical scavenging assays and nutritional contents. Submerged fermentation produced mycelia biomass (1.3 ± 0.1 g/L) within 14 days of fermentation. Both the pH and reduced sugar content had decreased (P &lt; 0.05) throughout fermentation. Vacuum dried mycelia had shown higher (P &lt; 0.05) total phenolic (20.0 ± 0.4 mg GAE/g), DPPH radical scavenging activity (84.7 ± 0.1%), and soluble protein content (283.6 ± 7.1 µg/mL) as compared to other treated samples. The crude protein (39.1 ± 0.2), fat (5.7 ± 0.7), ash (11.1 ± 0.3%) of mycelia were well preserved using vacuum drying as compared to oven dried samples. The study has suggested that vacuum drying at 70 °C, 1000mBar has the advantage to preserve the nutritional and radical scavenging activity of high value maitake mycelia effectively at lower cost.
DOI: 10.6084/m9.figshare.5634370.v1
title: Effect of vacuum and oven drying on the radical scavenging activity and nutritional contents of submerged fermented Maitake (Grifola frondosa) mycelia

description: Abstract Maitake (Grifola frondosa) mycelia contain high dietary and medicinal values that have gained great attentions from consumers. Proper drying can preserve their bio-availabilities prior to subsequent processing or consumption. Pure Maitake (Grifola frondosa) strain was cultivated in Mushroom Complete Medium (MCM) using submerged fermentation for 14 days. Maitake mycelia were harvested and treated respectively by vacuum, oven drying treatments while the fresh mycelia were assigned as control. All the samples were tested for Total Phenolic Content, DPPH radical scavenging assays and nutritional contents. Submerged fermentation produced mycelia biomass (1.3 ± 0.1 g/L) within 14 days of fermentation. Both the pH and reduced sugar content had decreased (P &lt; 0.05) throughout fermentation. Vacuum dried mycelia had shown higher (P &lt; 0.05) total phenolic (20.0 ± 0.4 mg GAE/g), DPPH radical scavenging activity (84.7 ± 0.1%), and soluble protein content (283.6 ± 7.1 µg/mL) as compared to other treated samples. The crude protein (39.1 ± 0.2), fat (5.7 ± 0.7), ash (11.1 ± 0.3%) of mycelia were well preserved using vacuum drying as compared to oven dried samples. The study has suggested that vacuum drying at 70 °C, 1000mBar has the advantage to preserve the nutritional and radical scavenging activity of high value maitake mycelia effectively at lower cost.
DOI: 10.6084/m9.figshare.5634367
title: Mortality trend due to intentionally self-inflicted injuries in Brazil from 2004 to 2014

description: ABSTRACT Objective To analyze mortality trends by intentionally self-inflicted injuries according to the age groups and regions of Brazil. Methods This is an epidemiological study, ecological type of temporal series, using data from the Mortality Information System related to deaths from intentional self-inflicted injuries in the period of 2004 to 2014. Results Trend analysis indicated increase in mortality rates, whereas Brazil curve accentuated elevation (R2 = 0.678). The Southeast region showed the highest straight slope (R2 = 0.960), being higher then trend observed in Brazil. Mortality coefficients according age groups showed an increasing tendency for the range of 10 to 19 years (R2 = 0.429). In the age group of 20 to 29 years in the analyzed period there was no tendency for growth. However, there was an increase in the number of deaths from the year 2010. This group was evaluated in the period 2010-2014, thus evidencing an increasing trend for this group (R2 = 0.927). The results point to the growth of mortality coefficients by self-inflicted injuries in Brazil and in all its regions, with the age group being the most understood 10 to 19 years old, followed by the age group of 20 to 59 years and those over 60 years. Conclusion The results point to the increase in mortality coefficients due to intentional self-inflicted injuries in Brazil and all regions, the most vulnerable age group being 10 to 19 years old, followed by the age group of 20 to 59 years and those over 60.
DOI: 10.6084/m9.figshare.5634367.v1
title: Mortality trend due to intentionally self-inflicted injuries in Brazil from 2004 to 2014

description: ABSTRACT Objective To analyze mortality trends by intentionally self-inflicted injuries according to the age groups and regions of Brazil. Methods This is an epidemiological study, ecological type of temporal series, using data from the Mortality Information System related to deaths from intentional self-inflicted injuries in the period of 2004 to 2014. Results Trend analysis indicated increase in mortality rates, whereas Brazil curve accentuated elevation (R2 = 0.678). The Southeast region showed the highest straight slope (R2 = 0.960), being higher then trend observed in Brazil. Mortality coefficients according age groups showed an increasing tendency for the range of 10 to 19 years (R2 = 0.429). In the age group of 20 to 29 years in the analyzed period there was no tendency for growth. However, there was an increase in the number of deaths from the year 2010. This group was evaluated in the period 2010-2014, thus evidencing an increasing trend for this group (R2 = 0.927). The results point to the growth of mortality coefficients by self-inflicted injuries in Brazil and in all its regions, with the age group being the most understood 10 to 19 years old, followed by the age group of 20 to 59 years and those over 60 years. Conclusion The results point to the increase in mortality coefficients due to intentional self-inflicted injuries in Brazil and all regions, the most vulnerable age group being 10 to 19 years old, followed by the age group of 20 to 59 years and those over 60.
DOI: 10.18112/openneuro.ds003105.v1.0.0
title: Fetal Tissue Annotation Challenge FeTA Dataset