cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.5281/zenodo.18220840
title: Sodium-Glucose Cotransporter-2 Inhibitors and Renal Function Decline in a Real-World Chronic Kidney Disease Cohort: A Propensity-Weighted Analysis with Multiple Imputation
DOI: 10.15156/bio/sh1247832.10fu
title: SH1247832.10FU

description: UNITE provides a unified way for delimiting, identifying, communicating, and working with DNA-based Species Hypotheses (SH). All fungal ITS sequences in the international nucleotide sequence databases are clustered to approximately the species level by applying a set of dynamic distance values (<0.5 - 3.0%). All species hypotheses are given a unique, stable name in the form of a DOI, and their taxonomic and ecological annotations are verified through distributed, web-based third-party annotation efforts. SHs are connected to a taxon name and its classification as far as possible (phylum, class, order, etc.) by taking into account identifications for all sequences in the SH. An automatically or manually designated sequence is chosen to represent each such SH. These sequences are released (https://unite.ut.ee/repository.php) for use by the scientific community in, for example, local sequence similarity searches and next-generation sequencing analysis pipelines. The system and the data are updated automatically as the number of public fungal ITS sequences grows.
DOI: 10.15156/bio/sh1247834.10fu
title: SH1247834.10FU

description: UNITE provides a unified way for delimiting, identifying, communicating, and working with DNA-based Species Hypotheses (SH). All fungal ITS sequences in the international nucleotide sequence databases are clustered to approximately the species level by applying a set of dynamic distance values (<0.5 - 3.0%). All species hypotheses are given a unique, stable name in the form of a DOI, and their taxonomic and ecological annotations are verified through distributed, web-based third-party annotation efforts. SHs are connected to a taxon name and its classification as far as possible (phylum, class, order, etc.) by taking into account identifications for all sequences in the SH. An automatically or manually designated sequence is chosen to represent each such SH. These sequences are released (https://unite.ut.ee/repository.php) for use by the scientific community in, for example, local sequence similarity searches and next-generation sequencing analysis pipelines. The system and the data are updated automatically as the number of public fungal ITS sequences grows.
DOI: 10.15156/bio/sh1247838.10fu
title: SH1247838.10FU

description: UNITE provides a unified way for delimiting, identifying, communicating, and working with DNA-based Species Hypotheses (SH). All fungal ITS sequences in the international nucleotide sequence databases are clustered to approximately the species level by applying a set of dynamic distance values (<0.5 - 3.0%). All species hypotheses are given a unique, stable name in the form of a DOI, and their taxonomic and ecological annotations are verified through distributed, web-based third-party annotation efforts. SHs are connected to a taxon name and its classification as far as possible (phylum, class, order, etc.) by taking into account identifications for all sequences in the SH. An automatically or manually designated sequence is chosen to represent each such SH. These sequences are released (https://unite.ut.ee/repository.php) for use by the scientific community in, for example, local sequence similarity searches and next-generation sequencing analysis pipelines. The system and the data are updated automatically as the number of public fungal ITS sequences grows.
DOI: 10.15156/bio/sh1247839.10fu
title: SH1247839.10FU

description: UNITE provides a unified way for delimiting, identifying, communicating, and working with DNA-based Species Hypotheses (SH). All fungal ITS sequences in the international nucleotide sequence databases are clustered to approximately the species level by applying a set of dynamic distance values (<0.5 - 3.0%). All species hypotheses are given a unique, stable name in the form of a DOI, and their taxonomic and ecological annotations are verified through distributed, web-based third-party annotation efforts. SHs are connected to a taxon name and its classification as far as possible (phylum, class, order, etc.) by taking into account identifications for all sequences in the SH. An automatically or manually designated sequence is chosen to represent each such SH. These sequences are released (https://unite.ut.ee/repository.php) for use by the scientific community in, for example, local sequence similarity searches and next-generation sequencing analysis pipelines. The system and the data are updated automatically as the number of public fungal ITS sequences grows.
DOI: 10.6084/m9.figshare.31047907
title: Supplementary Material for: Dynamic FIB‑4 Score Changes and HCC Risk in Patients with MASLD and Elevated Liver Enzymes: A Nationwide Cohort Study

description: Introduction: Hepatocellular carcinoma (HCC) can develop in individuals with metabolic dysfunction-associated steatotic liver disease (MASLD) without cirrhosis, especially those with elevated liver enzymes. However, there is currently no low-cost, scalable screening tool for this population. To address this need, we investigated the association between serial changes in FIB-4 (fibrosis-4) scores over a three-year period and the risk of developing HCC in a large, diverse cohort of patients with MASLD without cirrhosis.

Methods: This study utilized a nationwide cohort from the National Health Insurance Research Database (NHIRD), including 810,698 patients with MASLD who had demographic and laboratory data at baseline and at least 3 years of follow-up. FIB-4 scores were analyzed to assess transitions between low- (&lt;1.45), indeterminate- (1.45-2.67), and high-risk (&gt;2.67) categories over time. Competing risks for HCC and mortality were modeled to estimate the sub-distribution hazard ratios (SHRs).

Results: Changes in FIB-4 scores over time provided superior predictive accuracy compared to one-time measurement. Individuals with persistent high FIB-4 (high-to-high group) had a 14-fold higher risk of developing HCC (adjusted SHR [aSHR] 13.91, 95% CI 11.94-16.20) compared to those with stable low FIB-4 (low-to-low group), while those with improved scores (high-to-low and high-to-indeterminate groups) had a lower risk compared to the high-to-high group. Worsening FIB-4 scores, as shown in the low-to-indeterminate group (aSHR 2.22, 95% CI 1.93-2.57 or the low-to-high group (aSHR 4.75, 95% CI 3.38-6.68), were associated with progressively increased risks of HCC, compared to the low-to-low group. In contrast, when compared to the high-to-high group, those with improved FIB-4 scores, including the high-to-indeterminate group (aSHR 0.41, 95% CI 0.35-0.48) and the high-to-low group (aSHR 0.25, 95% CI 0.15-0.42), exhibited reduced HCC risks.

Conclusion: Serial FIB-4 measurements offer greater accuracy in identifying individuals at high risk for HCC in non-cirrhotic MASLD Asians, with HCC surveillance warranted in high-risk groups.
DOI: 10.6084/m9.figshare.31047907.v1
title: Supplementary Material for: Dynamic FIB‑4 Score Changes and HCC Risk in Patients with MASLD and Elevated Liver Enzymes: A Nationwide Cohort Study

description: Introduction: Hepatocellular carcinoma (HCC) can develop in individuals with metabolic dysfunction-associated steatotic liver disease (MASLD) without cirrhosis, especially those with elevated liver enzymes. However, there is currently no low-cost, scalable screening tool for this population. To address this need, we investigated the association between serial changes in FIB-4 (fibrosis-4) scores over a three-year period and the risk of developing HCC in a large, diverse cohort of patients with MASLD without cirrhosis.

Methods: This study utilized a nationwide cohort from the National Health Insurance Research Database (NHIRD), including 810,698 patients with MASLD who had demographic and laboratory data at baseline and at least 3 years of follow-up. FIB-4 scores were analyzed to assess transitions between low- (&lt;1.45), indeterminate- (1.45-2.67), and high-risk (&gt;2.67) categories over time. Competing risks for HCC and mortality were modeled to estimate the sub-distribution hazard ratios (SHRs).

Results: Changes in FIB-4 scores over time provided superior predictive accuracy compared to one-time measurement. Individuals with persistent high FIB-4 (high-to-high group) had a 14-fold higher risk of developing HCC (adjusted SHR [aSHR] 13.91, 95% CI 11.94-16.20) compared to those with stable low FIB-4 (low-to-low group), while those with improved scores (high-to-low and high-to-indeterminate groups) had a lower risk compared to the high-to-high group. Worsening FIB-4 scores, as shown in the low-to-indeterminate group (aSHR 2.22, 95% CI 1.93-2.57 or the low-to-high group (aSHR 4.75, 95% CI 3.38-6.68), were associated with progressively increased risks of HCC, compared to the low-to-low group. In contrast, when compared to the high-to-high group, those with improved FIB-4 scores, including the high-to-indeterminate group (aSHR 0.41, 95% CI 0.35-0.48) and the high-to-low group (aSHR 0.25, 95% CI 0.15-0.42), exhibited reduced HCC risks.

Conclusion: Serial FIB-4 measurements offer greater accuracy in identifying individuals at high risk for HCC in non-cirrhotic MASLD Asians, with HCC surveillance warranted in high-risk groups.
DOI: 10.15156/bio/sh1247840.10fu
title: SH1247840.10FU

description: UNITE provides a unified way for delimiting, identifying, communicating, and working with DNA-based Species Hypotheses (SH). All fungal ITS sequences in the international nucleotide sequence databases are clustered to approximately the species level by applying a set of dynamic distance values (<0.5 - 3.0%). All species hypotheses are given a unique, stable name in the form of a DOI, and their taxonomic and ecological annotations are verified through distributed, web-based third-party annotation efforts. SHs are connected to a taxon name and its classification as far as possible (phylum, class, order, etc.) by taking into account identifications for all sequences in the SH. An automatically or manually designated sequence is chosen to represent each such SH. These sequences are released (https://unite.ut.ee/repository.php) for use by the scientific community in, for example, local sequence similarity searches and next-generation sequencing analysis pipelines. The system and the data are updated automatically as the number of public fungal ITS sequences grows.
DOI: 10.15156/bio/sh1247842.10fu
title: SH1247842.10FU

description: UNITE provides a unified way for delimiting, identifying, communicating, and working with DNA-based Species Hypotheses (SH). All fungal ITS sequences in the international nucleotide sequence databases are clustered to approximately the species level by applying a set of dynamic distance values (<0.5 - 3.0%). All species hypotheses are given a unique, stable name in the form of a DOI, and their taxonomic and ecological annotations are verified through distributed, web-based third-party annotation efforts. SHs are connected to a taxon name and its classification as far as possible (phylum, class, order, etc.) by taking into account identifications for all sequences in the SH. An automatically or manually designated sequence is chosen to represent each such SH. These sequences are released (https://unite.ut.ee/repository.php) for use by the scientific community in, for example, local sequence similarity searches and next-generation sequencing analysis pipelines. The system and the data are updated automatically as the number of public fungal ITS sequences grows.
DOI: 10.6084/m9.figshare.31047910
title: Supplementary Material for: The influence of language dominance, type of language and narrative task on speech disfluencies in typically fluent bilingual English-Mandarin children

description: Introduction 

Speech disfluencies observed across multiple languages may reflect typical patterns of bilingual development rather than clinical stuttering, prompting a growing need to establish diagnostic criteria to improve the accuracy of stuttering assessment in bilingual individuals. While recent studies have begun to characterise normative disfluency patterns in fluent bilinguals, the manifestation of such disfluencies in languages such as Mandarin remains underexplored. This study investigates the frequency and type of disfluencies in typically developing bilingual children who speak English and Mandarin, and examines how language dominance, language type and narrative task demands influence their disfluency profiles. 

Method 

Thirty-six English-Mandarin speaking children comprising 16 balanced bilinguals (Mage = 5.61 years) and 20 English-dominant bilinguals (Mage = 5;56 years) were recruited from various kindergartens. Speech samples were collected across two narrative RETELL tasks (with and without visual guide) and in two languages (English and Mandarin) and were analysed for stuttering-like disfluencies (SLD), non-stuttering-like disfluencies (NSLD) and total disfluencies (TD). 

Results 

Approximately 55-65% of the bilingual English-Mandarin children in this study were found to exceed the monolingual diagnostic criteria for SLD, NSLD and TD in at least one speech sample. However, only a subset of children surpassed the thresholds across all measures. Monosyllabic word repetitions and revisions were among the most common SLD and NSLD, respectively. No significant differences in SLD, NSLD and TD were found between English-dominant and balanced bilinguals. While SLD did not appear to be influenced by language or task type, the frequency of NSLD and TD was found to be significantly higher in Mandarin and during narrative RETELL without visual guide. 

Conclusion 

The results demonstrate that bilingual children can produce disfluency patterns that are quantitatively and qualitatively different from monolingual and other bilingual populations. Clinically, this highlights the need for bilingual-specific diagnostic frameworks that account for language context, task demands, and different bilingual profiles.
DOI: 10.6084/m9.figshare.31047910.v1
title: Supplementary Material for: The influence of language dominance, type of language and narrative task on speech disfluencies in typically fluent bilingual English-Mandarin children

description: Introduction 

Speech disfluencies observed across multiple languages may reflect typical patterns of bilingual development rather than clinical stuttering, prompting a growing need to establish diagnostic criteria to improve the accuracy of stuttering assessment in bilingual individuals. While recent studies have begun to characterise normative disfluency patterns in fluent bilinguals, the manifestation of such disfluencies in languages such as Mandarin remains underexplored. This study investigates the frequency and type of disfluencies in typically developing bilingual children who speak English and Mandarin, and examines how language dominance, language type and narrative task demands influence their disfluency profiles. 

Method 

Thirty-six English-Mandarin speaking children comprising 16 balanced bilinguals (Mage = 5.61 years) and 20 English-dominant bilinguals (Mage = 5;56 years) were recruited from various kindergartens. Speech samples were collected across two narrative RETELL tasks (with and without visual guide) and in two languages (English and Mandarin) and were analysed for stuttering-like disfluencies (SLD), non-stuttering-like disfluencies (NSLD) and total disfluencies (TD). 

Results 

Approximately 55-65% of the bilingual English-Mandarin children in this study were found to exceed the monolingual diagnostic criteria for SLD, NSLD and TD in at least one speech sample. However, only a subset of children surpassed the thresholds across all measures. Monosyllabic word repetitions and revisions were among the most common SLD and NSLD, respectively. No significant differences in SLD, NSLD and TD were found between English-dominant and balanced bilinguals. While SLD did not appear to be influenced by language or task type, the frequency of NSLD and TD was found to be significantly higher in Mandarin and during narrative RETELL without visual guide. 

Conclusion 

The results demonstrate that bilingual children can produce disfluency patterns that are quantitatively and qualitatively different from monolingual and other bilingual populations. Clinically, this highlights the need for bilingual-specific diagnostic frameworks that account for language context, task demands, and different bilingual profiles.
DOI: 10.15156/bio/sh1247844.10fu
title: SH1247844.10FU

description: UNITE provides a unified way for delimiting, identifying, communicating, and working with DNA-based Species Hypotheses (SH). All fungal ITS sequences in the international nucleotide sequence databases are clustered to approximately the species level by applying a set of dynamic distance values (<0.5 - 3.0%). All species hypotheses are given a unique, stable name in the form of a DOI, and their taxonomic and ecological annotations are verified through distributed, web-based third-party annotation efforts. SHs are connected to a taxon name and its classification as far as possible (phylum, class, order, etc.) by taking into account identifications for all sequences in the SH. An automatically or manually designated sequence is chosen to represent each such SH. These sequences are released (https://unite.ut.ee/repository.php) for use by the scientific community in, for example, local sequence similarity searches and next-generation sequencing analysis pipelines. The system and the data are updated automatically as the number of public fungal ITS sequences grows.
DOI: 10.15156/bio/sh1247845.10fu
title: SH1247845.10FU

description: UNITE provides a unified way for delimiting, identifying, communicating, and working with DNA-based Species Hypotheses (SH). All fungal ITS sequences in the international nucleotide sequence databases are clustered to approximately the species level by applying a set of dynamic distance values (<0.5 - 3.0%). All species hypotheses are given a unique, stable name in the form of a DOI, and their taxonomic and ecological annotations are verified through distributed, web-based third-party annotation efforts. SHs are connected to a taxon name and its classification as far as possible (phylum, class, order, etc.) by taking into account identifications for all sequences in the SH. An automatically or manually designated sequence is chosen to represent each such SH. These sequences are released (https://unite.ut.ee/repository.php) for use by the scientific community in, for example, local sequence similarity searches and next-generation sequencing analysis pipelines. The system and the data are updated automatically as the number of public fungal ITS sequences grows.
DOI: 10.6084/m9.figshare.31047913
title: Supplementary Material for: Clinical characterization of probable Dementia with Lewy Bodies based on the initial clinical presentation in a Latin American Low- and Middle- Income Country

description: Background: Dementia with Lewy Bodies (DLB) is a distinct form of dementia characterized by the accumulation of alpha-synuclein in the brain. Early presentations are often heterogeneous, and the impact of this variability on disease progression remains poorly understood. This study explored the initial clinical presentation of DLB among Peruvian patients and its influence on the clinical course.
Methods: We conducted a retrospective study of patients diagnosed with DLB and Alzheimer’s disease (AD) using standard clinical criteria. Cognitive function was assessed using MMSE, INECO Frontal Screening (IFS), and Uniform Data Set (UDS). We classified DLB patients based on their initial symptoms (hallucinations or parkinsonism) and compared their clinical and neuropsychological characteristics. Statistical analyses (ANOVA, chi-squared, Wilcoxon tests, and multivariate linear regression) were used to evaluate group differences and examine how initial symptoms influenced disease progression and cognitive decline.
Results: Forty-six patients with probable DLB between June 2018 and May 2023 were included. The median time from symptom onset to diagnosis was five years. Cognitive symptoms were the most frequent initial presentation, followed by motor and behavioral signs. No significant clinical or neuropsychological differences were found between presentation subgroups at evaluation. Compared to AD patients, those with DLB scored higher on cognitive measures (MMSE, RUDAS) and behavioral symptoms (NPI). Neuropsychological testing revealed DLB patients had more pronounced deficits in visuospatial and executive functions than those with AD.
Conclusions: In our cohort, patients in the cognitive-onset group reached the threshold for dementia more rapidly. However, the initial presenting symptoms did not result in worse severity across specific cognitive or behavioral domains.
DOI: 10.6084/m9.figshare.31047913.v1
title: Supplementary Material for: Clinical characterization of probable Dementia with Lewy Bodies based on the initial clinical presentation in a Latin American Low- and Middle- Income Country

description: Background: Dementia with Lewy Bodies (DLB) is a distinct form of dementia characterized by the accumulation of alpha-synuclein in the brain. Early presentations are often heterogeneous, and the impact of this variability on disease progression remains poorly understood. This study explored the initial clinical presentation of DLB among Peruvian patients and its influence on the clinical course.
Methods: We conducted a retrospective study of patients diagnosed with DLB and Alzheimer’s disease (AD) using standard clinical criteria. Cognitive function was assessed using MMSE, INECO Frontal Screening (IFS), and Uniform Data Set (UDS). We classified DLB patients based on their initial symptoms (hallucinations or parkinsonism) and compared their clinical and neuropsychological characteristics. Statistical analyses (ANOVA, chi-squared, Wilcoxon tests, and multivariate linear regression) were used to evaluate group differences and examine how initial symptoms influenced disease progression and cognitive decline.
Results: Forty-six patients with probable DLB between June 2018 and May 2023 were included. The median time from symptom onset to diagnosis was five years. Cognitive symptoms were the most frequent initial presentation, followed by motor and behavioral signs. No significant clinical or neuropsychological differences were found between presentation subgroups at evaluation. Compared to AD patients, those with DLB scored higher on cognitive measures (MMSE, RUDAS) and behavioral symptoms (NPI). Neuropsychological testing revealed DLB patients had more pronounced deficits in visuospatial and executive functions than those with AD.
Conclusions: In our cohort, patients in the cognitive-onset group reached the threshold for dementia more rapidly. However, the initial presenting symptoms did not result in worse severity across specific cognitive or behavioral domains.