cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.12203204.v1
title: Mutational landscape of immune surveillance genes in diffuse large B-cell lymphoma

description: Immune surveillance is the dynamic process whereby the immune system identifies and kills tumor cells based on their aberrant expression of stress-related surface molecules or presentation of tumor neoantigens. It plays a crucial role in controlling the initiation and progression of hematologic cancers such as leukemia and lymphoma, and it has been reported that diffuse large B-cell lymphoma (DLBCL) fails to express specific cell-surface molecules that are necessary for the recognition and elimination of tumor cells. This review is based on a systematic search strategy to identify relevant literature in the PubMed and Embase databases. Ten candidate genes are identified based on mutational frequency, and functions with detailed mapping performed for hotspot alterations that may have a functional impact on malignant transformation and decreased immune surveillance efficacy. Ongoing development of technology and bioinformatics tools combined with data from large clinical cohorts have the potential to define the mutational landscape associated with immune surveillance in DLBCL. Specific functional studies are required to make an unambiguous link between genetic aberrations and biological impact on impaired immune surveillance.
DOI: 10.6084/m9.figshare.13187512
title: Real-world reduction in healthcare resource utilization following treatment of opioid use disorder with reSET-O, a novel prescription digital therapeutic

description: Buprenorphine medication assisted treatment (B-MAT) adherence for opioid use disorder (OUD) is suboptimal. reSET-O, an FDA-cleared prescription digital therapeutic, delivers neurobehavioral therapy (community-reinforcement approach+fluency training+contingency management) to B-MAT-treated OUD patients. This retrospective claims study (10/01/2018-10/31/2019) evaluated healthcare resource utilization up to 6 months before/after reSET-O initiation. Repeated-measures negative binomial models compared incidences of encounters/procedures. Net change in costs was assessed. Among 351 patients (mean age 37; 59.5% female; 82.6% Medicaid), 334 had pharmacy claims and 240 (71.9%) received buprenorphine pre-/post-index (medication possession ratio 0.73 and 0.82, respectively; <i>P = </i>0.004). Facility encounters decreased, with 45 fewer inpatient (<i>P = </i>0.024) and 27 fewer emergency department (ED) visits (<i>P = </i>0.247). Clinical encounters with largest changes were drug testing (638 fewer; <i>P 0.001), psychiatry (349 fewer; <i>P = </i>0.036), case management (176 additional; <i>P = </i>0.588), other pathology/laboratory (166 fewer; <i>P = </i>0.039), office/other outpatient (154 fewer; <i>P = </i>0.302), behavioral rehabilitation (111 additional; <i>P = </i>0.124), alcohol/substance rehabilitation (96 fewer; <i>P = </i>0.348), other rehabilitation (66 fewer; <i>P = </i>0.387), mental health rehabilitation (61 additional; <i>P = </i>0.097), and surgery (60 fewer; <i>P = </i>0.070). Changes in facility/clinical encounters saved $2,150/patient.</i> reSET-O initiation was associated with fewer inpatient, ED, and other clinical encounters, increased case management/rehabilitative services, and lower net costs over six months. Real-world evidence is helpful in evaluating the effectiveness of interventions in usual-care conditions, outside of controlled research environments. Large observational studies based on health care claims are important to understand the actual pharmacoeconomic and outcomes impact of interventions at the health care system and population level.
DOI: 10.6084/m9.figshare.10745030
title: Estimating the money flow in the economy attributed to rotavirus disease and vaccination in the Netherlands using a Social Accounting Matrix (SAM) framework

description: <b>Background</b>: The economics of rotavirus gastroenteritis in infants &lt;5 years old is well-known within healthcare. The financial consequences for families, employers and authorities are not so well explored. The present study evaluates how vaccine prevention changes money flows among those involved in the management of disease, and its consequences. <b>Methods</b>: A Social Accounting Matrix (SAM) framework has been developed reflecting the distribution of income and spending at equilibrium affected by rotavirus disease among all those concerned for 1 year. The data came from official sources and published literature. A comparison of the financial equilibrium between with and without a national rotavirus immunization program has been conducted, along with sensitivity analysis for the results. <b>Results</b>: The total financial cost difference at equilibrium between presence and absence of rotavirus vaccination was +€26.758 million over one year as a net economic surplus. The payment of vaccination (€19.194 million) by the government was offset by the increase in tax revenue (€14.561 million) and by the lower spending in treatment care (€7.998 million). <b>Conclusion</b>: Studying the financial flows between different transacting agents can demonstrate the financial burden of a disease and the benefits of its prevention on agents’ income and spending.
DOI: 10.6084/m9.figshare.10745030.v1
title: Estimating the money flow in the economy attributed to rotavirus disease and vaccination in the Netherlands using a Social Accounting Matrix (SAM) framework

description: <b>Background</b>: The economics of rotavirus gastroenteritis in infants &lt;5 years old is well-known within healthcare. The financial consequences for families, employers and authorities are not so well explored. The present study evaluates how vaccine prevention changes money flows among those involved in the management of disease, and its consequences. <b>Methods</b>: A Social Accounting Matrix (SAM) framework has been developed reflecting the distribution of income and spending at equilibrium affected by rotavirus disease among all those concerned for 1 year. The data came from official sources and published literature. A comparison of the financial equilibrium between with and without a national rotavirus immunization program has been conducted, along with sensitivity analysis for the results. <b>Results</b>: The total financial cost difference at equilibrium between presence and absence of rotavirus vaccination was +€26.758 million over one year as a net economic surplus. The payment of vaccination (€19.194 million) by the government was offset by the increase in tax revenue (€14.561 million) and by the lower spending in treatment care (€7.998 million). <b>Conclusion</b>: Studying the financial flows between different transacting agents can demonstrate the financial burden of a disease and the benefits of its prevention on agents’ income and spending.
DOI: 10.6084/m9.figshare.9887552
title: Economic evaluation of a home-based programme to reduce concerns about falls in frail, independently-living older people

description: <b>Background</b>: Concerns about falls, or fear of falling, are frequently reported by older people and can have serious consequences. Aim of this study was to evaluate the cost-effectiveness of a home-based, cognitive behavioral programme for independently-living, frail older people in comparison with usual care from a societal perspective. <b>Methods</b>: This economic evaluation was embedded in a randomized-controlled trial with a follow-up of 12-months. In the trial 389 people aged 70 years or older were allocated to usual care (n = 195) or the intervention group (n = 194). The intervention group received a home-based, cognitive behavioral programme. Main outcome measures were concerns about falls and Quality Adjusted Life Years (QALYs). <b>Results</b>: Average total costs per participant in the usual care group were 8,094 Euros and 7,890 Euros for participants in the intervention group. The intervention group showed a significant decrease in concerns about falls and a non-significant increase in QALYS in comparison with the usual care group. The probability that the intervention was cost-effective was 75% at a willingness to pay of 20,000 Euros per QALY. <b>Discussion</b>: The programme is likely to be cost-effective, and therefore a useful addition to current geriatric care, particularly for those persons who are not able or willing to attend group programmes. <b>Trial registration</b>: NCT01358032
DOI: 10.6084/m9.figshare.9887552.v1
title: Economic evaluation of a home-based programme to reduce concerns about falls in frail, independently-living older people

description: <b>Background</b>: Concerns about falls, or fear of falling, are frequently reported by older people and can have serious consequences. Aim of this study was to evaluate the cost-effectiveness of a home-based, cognitive behavioral programme for independently-living, frail older people in comparison with usual care from a societal perspective. <b>Methods</b>: This economic evaluation was embedded in a randomized-controlled trial with a follow-up of 12-months. In the trial 389 people aged 70 years or older were allocated to usual care (n = 195) or the intervention group (n = 194). The intervention group received a home-based, cognitive behavioral programme. Main outcome measures were concerns about falls and Quality Adjusted Life Years (QALYs). <b>Results</b>: Average total costs per participant in the usual care group were 8,094 Euros and 7,890 Euros for participants in the intervention group. The intervention group showed a significant decrease in concerns about falls and a non-significant increase in QALYS in comparison with the usual care group. The probability that the intervention was cost-effective was 75% at a willingness to pay of 20,000 Euros per QALY. <b>Discussion</b>: The programme is likely to be cost-effective, and therefore a useful addition to current geriatric care, particularly for those persons who are not able or willing to attend group programmes. <b>Trial registration</b>: NCT01358032
DOI: 10.6084/m9.figshare.12016365.v1
title: Ruxolitinib for treatment of steroid-refractory graft-versus-host disease in adults: a systematic review and meta-analysis

description: Authors assessed the impact of ruxolitinib (RUX) on steroid-refractory graft-versus-host disease (SR-GVHD) patients. Studies published before January 2019 were identified by electronic search of MEDLINE, EMBASE, Cochrane Library, Clinical Trials.Gov and Web of Science databases. Sixteen cohort studies (414 adults) were included whose methodological quality ranged from poor to good. Pooled outcomes such as the response rates, steroid dose reduction, 1-year overall survival, overall infection, and grade 3 to 4 cytopenia were calculated separately for adults with steroid-refractory acute GVHD (aGVHD) and chronic GVHD (cGVHD). Further, the overall response rates were analyzed according to the affected organ. Adults with aGVHD as well as cGVHD showed high response with RUX, and steroid dose reduction was observed in both cases. Infection rates and cytopenia were important safety concerns for both aGVHD and cGVHD. Notwithstanding the need of randomized controlled trials to confirm the effect of RUX on SR-GVHD, response rates among adults with aGVHD and cGVHD seem to be high with the use of RUX as a salvage treatment, particularly in cases with gastrointestinal and cutaneous involvement. However, high rates of myelosuppression and infection remain a cause for concern regardless of aGVHD or cGVHD.
DOI: 10.6084/m9.figshare.12016365
title: Ruxolitinib for treatment of steroid-refractory graft-versus-host disease in adults: a systematic review and meta-analysis

description: Authors assessed the impact of ruxolitinib (RUX) on steroid-refractory graft-versus-host disease (SR-GVHD) patients. Studies published before January 2019 were identified by electronic search of MEDLINE, EMBASE, Cochrane Library, Clinical Trials.Gov and Web of Science databases. Sixteen cohort studies (414 adults) were included whose methodological quality ranged from poor to good. Pooled outcomes such as the response rates, steroid dose reduction, 1-year overall survival, overall infection, and grade 3 to 4 cytopenia were calculated separately for adults with steroid-refractory acute GVHD (aGVHD) and chronic GVHD (cGVHD). Further, the overall response rates were analyzed according to the affected organ. Adults with aGVHD as well as cGVHD showed high response with RUX, and steroid dose reduction was observed in both cases. Infection rates and cytopenia were important safety concerns for both aGVHD and cGVHD. Notwithstanding the need of randomized controlled trials to confirm the effect of RUX on SR-GVHD, response rates among adults with aGVHD and cGVHD seem to be high with the use of RUX as a salvage treatment, particularly in cases with gastrointestinal and cutaneous involvement. However, high rates of myelosuppression and infection remain a cause for concern regardless of aGVHD or cGVHD.
DOI: 10.25345/c5rg05
title: MassIVE MSV000087382 - GNPS_Srigolactone_Hemp_exsudat-10-12_method_MS02_traite4
title: Research in hemp exudate of cannabis sativa strigolactone by MS/MS with various Strigolactone control and a blank in acetonitrile.
DOI: 10.5517/ccdc.csd.cc1nppkl
title: CCDC 1540190: Experimental Crystal Structure Determination

description: Related Article: Agnieszka Szyszkowska, Karol Hęclik, Sylwia Pawlędzio, Damian Trzybiński, Krzysztof Woźniak, Antonin Klasek, Iwona Zarzyka|2019|Struct.Chem.|30|1079|doi:10.1007/s11224-018-1247-5
DOI: 10.5517/ccdc.csd.cc27tf7r
title: CCDC 2080014: Experimental Crystal Structure Determination

description: Related Article: Y. Okumura, Y. Takiguchi, D. Nakane, T. Akitsu|2021|Acta Crystallogr.,Sect.E:Cryst.Commun.|77|579|doi:10.1107/S2056989021004424
DOI: 10.5517/ccdc.csd.cc27tfcw
title: CCDC 2080018: Experimental Crystal Structure Determination

description: Related Article: V. Schmitt, G. Holzmann, D. Schollmeyer, H. Detert|2021|IUCrData|6|x210443|doi:10.1107/S2414314621004430
DOI: 10.5517/ccdc.csd.cc27thg1
title: CCDC 2080083: Experimental Crystal Structure Determination

description: Related Article: B.J. Elvers, C. Fischer, C. Schulzke|2021|Acta Crystallogr.,Sect.E:Cryst.Commun.|77|583|doi:10.1107/S2056989021004448
DOI: 10.5517/ccdc.csd.cc27v0bg
title: CCDC 2080575: Experimental Crystal Structure Determination

description: Related Article: W. Clegg, G.S. Nichol|2021|CSD Communication|||
DOI: 10.5517/ccdc.csd.cc27v0ch
title: CCDC 2080576: Experimental Crystal Structure Determination

description: Related Article: W. Clegg, G.S. Nichol|2021|CSD Communication|||
DOI: 10.5517/ccdc.csd.cc27v0dj
title: CCDC 2080577: Experimental Crystal Structure Determination

description: Related Article: W. Clegg, G.S. Nichol|2021|CSD Communication|||
DOI: 10.5517/ccdc.csd.cc27v0fk
title: CCDC 2080578: Experimental Crystal Structure Determination

description: Related Article: W. Clegg, G.S. Nichol|2021|CSD Communication|||
DOI: 10.5517/ccdc.csd.cc27v0gl
title: CCDC 2080579: Experimental Crystal Structure Determination

description: Related Article: W. Clegg, G.S. Nichol|2021|CSD Communication|||
DOI: 10.5517/ccdc.csd.cc27v0hm
title: CCDC 2080580: Experimental Crystal Structure Determination

description: Related Article: W. Clegg, G.S. Nichol|2021|CSD Communication|||
DOI: 10.5517/ccdc.csd.cc27v8yb
title: CCDC 2080842: Experimental Crystal Structure Determination

description: Related Article: Frank R. Fronczek|2021|CSD Communication|||
DOI: 10.5517/ccdc.csd.cc27w17f
title: CCDC 2081564: Experimental Crystal Structure Determination

description: Related Article: W. Clegg, K. Guille|2021|CSD Communication|||
DOI: 10.12751/g-node.gbtaqn
title: Data for Lattenkamp et al., 2021, “The vocal development of the pale spear-nosed bat is dependent on auditory feedback”

description: Acoustic call parameters, auditory brainstem responses, and data analysis programs for Lattenkamp et al., 2021, “The vocal development of the pale spear-nosed bat is dependent on auditory feedback”.
DOI: 10.6084/m9.figshare.14555480
title: S6. Raman spectra of exfoliated graphene from Graphene production by cracking

description: In recent years, graphene has found its use in numerous industrial applications due to its unique properties. While its impermeable and conductive nature can replace currently used anticorrosive toxic pigments in coating systems, due to its large strength to weight ratio, graphene can be an important component as a next-generation additive for automotive, aerospace and construction applications. The current bottlenecks in using graphene and graphene oxide and other two-dimensional materials are the availability of cost-effective, high-quality materials and their effective incorporation (functionalization and dispersion) into the product matrices. On overcoming these factors, graphene may attract significant demands in terms of volume consumption. Graphene can be produced on industrial scales and through cost-effective top-down routes such as chemical, electrochemical and/or high-pressure mechanical exfoliation. Graphene, depending on end applications, can be chemically tuned and modified via functionalization so that easy incorporation into product matrices is possible. This paper discusses different production methods and their impact on the quality of graphene produced in terms of energy input. Graphene with an average thickness below five layers was produced by both methods with varied defects. However, a higher yield of graphene with a lower number of layers was produced via the high-pressure exfoliation route.This article is part of a discussion meeting issue ‘A cracking approach to inventing new tough materials: fracture stranger than friction’.
DOI: 10.5281/zenodo.4742407
title: Mechanistic insights on the anionic polymerization of aldehydes

description: Calculations - SI
DOI: 10.6084/m9.figshare.14555483
title: S10. XPS of high pressure exfoliated graphene from Graphene production by cracking

description: In recent years, graphene has found its use in numerous industrial applications due to its unique properties. While its impermeable and conductive nature can replace currently used anticorrosive toxic pigments in coating systems, due to its large strength to weight ratio, graphene can be an important component as a next-generation additive for automotive, aerospace and construction applications. The current bottlenecks in using graphene and graphene oxide and other two-dimensional materials are the availability of cost-effective, high-quality materials and their effective incorporation (functionalization and dispersion) into the product matrices. On overcoming these factors, graphene may attract significant demands in terms of volume consumption. Graphene can be produced on industrial scales and through cost-effective top-down routes such as chemical, electrochemical and/or high-pressure mechanical exfoliation. Graphene, depending on end applications, can be chemically tuned and modified via functionalization so that easy incorporation into product matrices is possible. This paper discusses different production methods and their impact on the quality of graphene produced in terms of energy input. Graphene with an average thickness below five layers was produced by both methods with varied defects. However, a higher yield of graphene with a lower number of layers was produced via the high-pressure exfoliation route.This article is part of a discussion meeting issue ‘A cracking approach to inventing new tough materials: fracture stranger than friction’.
DOI: 10.6084/m9.figshare.14555483.v1
title: S10. XPS of high pressure exfoliated graphene from Graphene production by cracking

description: In recent years, graphene has found its use in numerous industrial applications due to its unique properties. While its impermeable and conductive nature can replace currently used anticorrosive toxic pigments in coating systems, due to its large strength to weight ratio, graphene can be an important component as a next-generation additive for automotive, aerospace and construction applications. The current bottlenecks in using graphene and graphene oxide and other two-dimensional materials are the availability of cost-effective, high-quality materials and their effective incorporation (functionalization and dispersion) into the product matrices. On overcoming these factors, graphene may attract significant demands in terms of volume consumption. Graphene can be produced on industrial scales and through cost-effective top-down routes such as chemical, electrochemical and/or high-pressure mechanical exfoliation. Graphene, depending on end applications, can be chemically tuned and modified via functionalization so that easy incorporation into product matrices is possible. This paper discusses different production methods and their impact on the quality of graphene produced in terms of energy input. Graphene with an average thickness below five layers was produced by both methods with varied defects. However, a higher yield of graphene with a lower number of layers was produced via the high-pressure exfoliation route.This article is part of a discussion meeting issue ‘A cracking approach to inventing new tough materials: fracture stranger than friction’.
DOI: 10.6084/m9.figshare.14555486
title: S8. FEG-TEM images of electrochemically exfolaited graphene from Graphene production by cracking

description: In recent years, graphene has found its use in numerous industrial applications due to its unique properties. While its impermeable and conductive nature can replace currently used anticorrosive toxic pigments in coating systems, due to its large strength to weight ratio, graphene can be an important component as a next-generation additive for automotive, aerospace and construction applications. The current bottlenecks in using graphene and graphene oxide and other two-dimensional materials are the availability of cost-effective, high-quality materials and their effective incorporation (functionalization and dispersion) into the product matrices. On overcoming these factors, graphene may attract significant demands in terms of volume consumption. Graphene can be produced on industrial scales and through cost-effective top-down routes such as chemical, electrochemical and/or high-pressure mechanical exfoliation. Graphene, depending on end applications, can be chemically tuned and modified via functionalization so that easy incorporation into product matrices is possible. This paper discusses different production methods and their impact on the quality of graphene produced in terms of energy input. Graphene with an average thickness below five layers was produced by both methods with varied defects. However, a higher yield of graphene with a lower number of layers was produced via the high-pressure exfoliation route.This article is part of a discussion meeting issue ‘A cracking approach to inventing new tough materials: fracture stranger than friction’.
DOI: 10.5281/zenodo.4742406
title: Mechanistic insights on the anionic polymerization of aldehydes

description: Calculations - SI