cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.8248544
title: Impact of Revascularization Completeness on Outcomes of Patients with Coronary Artery Disease Undergoing Transcatheter Aortic Valve Replacement

description: <b>Background:</b> Coronary artery disease (CAD) is common in aortic stenosis patients, but its proper management in the setting of transcatheter aortic valve replacement (TAVR) is not established. We sought to explore whether the extent of revascularization by percutaneous coronary intervention (PCI) has an impact on clinical outcomes after TAVR. <b>Methods:</b> Out of 875 consecutive patients, 303 underwent PCI prior to TAVR. Baseline (pre-PCI) and residual (post-PCI) SYNTAX score (bSS and rSS), as well as their ratio (SYNTAX revascularization index, SRI) were calculated for 207 patients who underwent PCI for native CAD at a median of four days before TAVR. The endpoints were the 30-day safety endpoint (VARC-2 definition) and 1-year mortality. <b>Results:</b> In patients undergoing PCI prior to TAVR, bSS was 11.0 ± 7.2, rSS was 2.8 ± 5.3, and SRI was 81.7 ± 27.9%. Complete revascularization (rSS = 0 and SRI = 100%) was achieved in 129 patients (62.3%). The rate of the 30-day safety endpoint was influenced by the STS score and the bSS, but not by the completeness of coronary revascularization. At one year post-TAVR, complete revascularization was associated with a lower mortality (adjusted HR, 0.450 [0.218–0.926], <i>p</i> = 0.030). This mortality advantage was more evident in patients with multivessel CAD (n = 130; HR, 0.304 [0.120–0.772]) than in patients with single-vessel CAD (n = 77; HR, 0.752 [0.207–2.731]). <b>Conclusions:</b> In patients with CAD undergoing TAVR, complete percutaneous coronary revascularization is safe and associated with lower one-year mortality, especially in patients with multivessel CAD.
DOI: 10.6084/m9.figshare.8248544.v1
title: Impact of Revascularization Completeness on Outcomes of Patients with Coronary Artery Disease Undergoing Transcatheter Aortic Valve Replacement

description: <b>Background:</b> Coronary artery disease (CAD) is common in aortic stenosis patients, but its proper management in the setting of transcatheter aortic valve replacement (TAVR) is not established. We sought to explore whether the extent of revascularization by percutaneous coronary intervention (PCI) has an impact on clinical outcomes after TAVR. <b>Methods:</b> Out of 875 consecutive patients, 303 underwent PCI prior to TAVR. Baseline (pre-PCI) and residual (post-PCI) SYNTAX score (bSS and rSS), as well as their ratio (SYNTAX revascularization index, SRI) were calculated for 207 patients who underwent PCI for native CAD at a median of four days before TAVR. The endpoints were the 30-day safety endpoint (VARC-2 definition) and 1-year mortality. <b>Results:</b> In patients undergoing PCI prior to TAVR, bSS was 11.0 ± 7.2, rSS was 2.8 ± 5.3, and SRI was 81.7 ± 27.9%. Complete revascularization (rSS = 0 and SRI = 100%) was achieved in 129 patients (62.3%). The rate of the 30-day safety endpoint was influenced by the STS score and the bSS, but not by the completeness of coronary revascularization. At one year post-TAVR, complete revascularization was associated with a lower mortality (adjusted HR, 0.450 [0.218–0.926], <i>p</i> = 0.030). This mortality advantage was more evident in patients with multivessel CAD (n = 130; HR, 0.304 [0.120–0.772]) than in patients with single-vessel CAD (n = 77; HR, 0.752 [0.207–2.731]). <b>Conclusions:</b> In patients with CAD undergoing TAVR, complete percutaneous coronary revascularization is safe and associated with lower one-year mortality, especially in patients with multivessel CAD.
DOI: 10.6084/m9.figshare.8798504.v1
title: Myocardial Injury Post Transcatheter Aortic Valve Implantation Comparing Mechanically Expanded Versus Self-Expandable Versus Balloon Expandable Valves

description: <b>Background</b>: Myocardial injury is common with transcatheter aortic valve implantation (TAVI) and may predict poor outcome. We aim 1) to evaluate the difference in change of high sensitive Troponin T (hsTnT) within 24 hours after transfemoral-TAVI between mechanically-expanded (MEV), self-expanding (SEV) and balloon-expandable (BEV) valves, 2) to determine predictors for myocardial injury post-TAVI and 3) to assess whether myocardial injury is associated with 30-day mortality. <b>Methods</b>: This multicenter retrospective observational study included 1208 consecutively treated transfemoral-TAVI patients from three European centers. All patients treated with a MEV, SEV or BEV with available hsTnT measurements at baseline and within 24 hours post-TAVI were included. Significant myocardial injury was defined as an elevation of hsTnT exceeding ≥ 15x the upper reference limit . <b>Results</b>: Overall, the median hsTnT rise was 741 ng/L and was lower with MEV than with SEV or BEV (MEV 335 vs. SEV 901 vs. BEV 649 ng/L, p&lt;0.001). Myocardial injury occurred in 925 patients (77%) and was less frequent with MEV (MEV 67%, SEV 79% and BEV 76%, p=0.007). Occurrence of myocardial injury was similar after implantation of first vs. second generation SEV (79 vs. 80%, p=0.72) and BEV (77 vs. 76%, p=0.90). There was no association between frequency of annulus manipulation and myocardial injury. On multivariate analysis (OR (95%CI) non-MEV (1.63 (1.06-2.49), p=0.025), mean aortic gradient (1.02 (1.01-1.03), p&lt;0.001), left ventricular ejection fraction (1.03 (1.01-1.04), p&lt;0.001), and previous myocardial infarction (1.62 (1.04-2.56), p=0.032) were positively associated with myocardial injury. There was no association between myocardial injury and 30-day mortality. <b>Conclusion</b>: Transcatheter valve design determines peri-procedural myocardial injury and is less frequent with MEV. Myocardial injury is not associated with 30-day mortality.
DOI: 10.6084/m9.figshare.8940308.v1
title: Imaging for Percutaneous Left Atrial Appendage Closure: A Contemporary Review

description: Embolic stroke is the most significant complication of atrial fibrillation (AF). Oral anticoagulation (OAC) agents have an established role to prevent stroke in patients with AF. However, in patients who have near-fatal bleeding events during treatment with OAC, alternative, non-pharmacological methods of stroke prevention are needed. The left atrial appendage (LAA) is the most common source of thrombi in AF and recently, mechanical, percutaneous occlusion of the LAA has emerged as an effective strategy for stroke prophylaxis in patients deemed high risk for OAC-related bleeding. Although percutaneous LAA occlusion offers a significant step forward in AF stroke risk prevention, the procedural risks are not trivial and include device leakage, embolization, cardiac perforation, tamponade and death. To minimize these risks and improve LAA occlusion outcomes, optimal peri-procedural imaging is critical to ensure accurate sizing and safe implantation. In this review of LAA occlusion, we present the current, clinically used percutaneous devices and provide a focused review of the latest imaging approaches used for evaluation of the LAA before, during, and after occlusion.
DOI: 10.6084/m9.figshare.12110988.v1
title: Transcatheter Repair of an Iatrogenic Aorta to Right Ventricular Fistula following TAVR

description: Transcatheter Repair of an Iatrogenic Aorta to Right Ventricular Fistula following TAVR
DOI: 10.6084/m9.figshare.12129780.v2
title: Red Cell Shearing between Transcatheter Heart Valves? Acute Hemolysis after Emergency TAVR-in-TAVR

description: Red Cell Shearing between Transcatheter Heart Valves? Acute Hemolysis after Emergency TAVR-in-TAVR
DOI: 10.6084/m9.figshare.12129780
title: Red Cell Shearing between Transcatheter Heart Valves? Acute Hemolysis after Emergency TAVR-in-TAVR

description: Red Cell Shearing between Transcatheter Heart Valves? Acute Hemolysis after Emergency TAVR-in-TAVR
DOI: 10.6084/m9.figshare.12110988
title: Transcatheter Repair of an Iatrogenic Aorta to Right Ventricular Fistula following TAVR

description: Transcatheter Repair of an Iatrogenic Aorta to Right Ventricular Fistula following TAVR
DOI: 10.6084/m9.figshare.12129780.v1
title: Red Cell Shearing Between Transcatheter Heart Valves? Acute Hemolysis after Emergency TAVR-in-TAVR

description: Red Cell Shearing Between Transcatheter Heart Valves? Acute Hemolysis after Emergency TAVR-in-TAVR
DOI: 10.5066/p9g3p0sc
title: Multibeam bathymetry in Peoria Lock, near Peoria, Illinois, September 19, 2019

description: The bathymetry (bottom elevation) of the downstream lock approach and lock chamber of Peoria Lock, near Peoria, Illinois, was surveyed on September 19, 2019. The data were collected using a multibeam echo-sounder mapping system (MBMS) with integrated inertial navigation solution (INS) mounted on a manned survey vessel. The raw data were processed and gridded to 0.5 meter using elevation values computed from the Combined Uncertainty and Bathymetry Estimator (CUBE) method, which provides an estimate of the bathymetric elevation and the total propagated uncertainty (TPU) at each gridded location. The 0.5 meter grid was oriented at 39.32 degrees to north to be aligned with the Peoria lock chamber. The bathymetry and TPU data were exported as text files.
DOI: 10.6084/m9.figshare.13058499
title: Testing a Popular Smartphone Application for Colour Vision Assessment in Healthy Volunteer Subjects

description: We aimed to compare the Ishihara pseudoisochromatic colour vision test with a colour vision test from a popular smartphone application (EyeHandBook [EHB]) using digital image processing to simulate colour vision deficiencies. Three digital versions of the Ishihara and EHB slides were created: full colour; 32 bit- greyscale (removing all colour information); and blue channel (to simulate red-green colour vision deficiencies). Twenty healthy volunteers were shown each colour-edited plate. The answers they reported were compared with what would be expected for that colour-simulation scenario based on the answer key provided in the Ishihara booklet (“expected” answer). There were nine plates that had comparable patterns between the EHB and Ishihara test. We found no significant difference in the overall proportion of “expected” answers for the full colour (p = .35), 32 bit-greyscale (p = .39) and blue channel (p = .22) conditions. There were significant differences between the proportion of “expected” answers among six individual colour- edited plates (p &lt; .05 for each). Colour vision assessment from the EHB is distinct from comparable Ishihara plates. Clinical scenarios that require serial assessment of colour vision may benefit from using the same modality consistently rather than exchanging between the two tests with the assumption of equivalence. Refinement of digital colour editing techniques beyond 32-bit greyscale and RGB channel splitting is necessary in order to accurately simulate colour vision deficiency.
DOI: 10.6084/m9.figshare.13058499.v1
title: Testing a Popular Smartphone Application for Colour Vision Assessment in Healthy Volunteer Subjects

description: We aimed to compare the Ishihara pseudoisochromatic colour vision test with a colour vision test from a popular smartphone application (EyeHandBook [EHB]) using digital image processing to simulate colour vision deficiencies. Three digital versions of the Ishihara and EHB slides were created: full colour; 32 bit- greyscale (removing all colour information); and blue channel (to simulate red-green colour vision deficiencies). Twenty healthy volunteers were shown each colour-edited plate. The answers they reported were compared with what would be expected for that colour-simulation scenario based on the answer key provided in the Ishihara booklet (“expected” answer). There were nine plates that had comparable patterns between the EHB and Ishihara test. We found no significant difference in the overall proportion of “expected” answers for the full colour (p = .35), 32 bit-greyscale (p = .39) and blue channel (p = .22) conditions. There were significant differences between the proportion of “expected” answers among six individual colour- edited plates (p &lt; .05 for each). Colour vision assessment from the EHB is distinct from comparable Ishihara plates. Clinical scenarios that require serial assessment of colour vision may benefit from using the same modality consistently rather than exchanging between the two tests with the assumption of equivalence. Refinement of digital colour editing techniques beyond 32-bit greyscale and RGB channel splitting is necessary in order to accurately simulate colour vision deficiency.
DOI: 10.6084/m9.figshare.11607969
title: Pendular See-Saw Nystagmus: A Rare Presenting Manifestation of Craniopharyngioma

description: Pendular see-saw nystagmus is an extremely rare form of nystagmus characterised by cyclical movement of the eyes with a conjugate torsional component and a disjunctive vertical component. Intorsion and elevation of one eye is accompanied by simultaneous extorsion and depression of the contralateral eye. Most commonly it results from a suprasellar/parasellar mass compressing the meso-diencephalic region. Herein, we report a case of a 5-year-old girl who presented with pendular see-saw nystagmus secondary to a craniopharyngioma. The nystagmus resolved following excision of the lesion.
DOI: 10.6084/m9.figshare.13141370
title: Combined treatment with auranofin and trametinib induces synergistic apoptosis in breast cancer cells

description: Auranofin is a gold complex used as an anti-rheumatic agent and may act as a potent anticancer drug against breast tumors. Trametinib is a specific mitogen-activated protein kinase inhibitor, approved for the treatment of metastatic melanoma. The aim of this study was to examine the synergistic effects of auranofin and trametinib on apoptosis in MCF-7 human breast cancer cells. The combination treatment inhibited cancer cell proliferation and induced cell cycle arrest at the sub-G1 phase and apoptosis via poly (ADP-ribose) polymerase cleavage and caspase-3/7 activation. It is noteworthy that this treatment significantly increased p38 mitogen-activated protein kinase (MAPK) phosphorylation to induce mitochondrial stress, subsequently promoting cancer cell apoptosis through release of apoptosis-inducing factor. Further data demonstrated that combined treatment significantly induced increase in nuclear translocation of AIF. These results indicated that activation of the p38 MAPK signaling pathway and mitochondrial apoptosis may contribute to the synergistic consequences in MCF-7 cells. Collectively, our data demonstrated that combined treatment with auranofin and trametinib exhibited synergistic breast cancer cell death and this combination might be utilized as a novel therapeutic strategy for breast cancer.
DOI: 10.6084/m9.figshare.13141370.v1
title: Combined treatment with auranofin and trametinib induces synergistic apoptosis in breast cancer cells

description: Auranofin is a gold complex used as an anti-rheumatic agent and may act as a potent anticancer drug against breast tumors. Trametinib is a specific mitogen-activated protein kinase inhibitor, approved for the treatment of metastatic melanoma. The aim of this study was to examine the synergistic effects of auranofin and trametinib on apoptosis in MCF-7 human breast cancer cells. The combination treatment inhibited cancer cell proliferation and induced cell cycle arrest at the sub-G1 phase and apoptosis via poly (ADP-ribose) polymerase cleavage and caspase-3/7 activation. It is noteworthy that this treatment significantly increased p38 mitogen-activated protein kinase (MAPK) phosphorylation to induce mitochondrial stress, subsequently promoting cancer cell apoptosis through release of apoptosis-inducing factor. Further data demonstrated that combined treatment significantly induced increase in nuclear translocation of AIF. These results indicated that activation of the p38 MAPK signaling pathway and mitochondrial apoptosis may contribute to the synergistic consequences in MCF-7 cells. Collectively, our data demonstrated that combined treatment with auranofin and trametinib exhibited synergistic breast cancer cell death and this combination might be utilized as a novel therapeutic strategy for breast cancer.
DOI: 10.6084/m9.figshare.13193518.v1
title: Docosahexaenoic acid impacts macrophage phenotype subsets and phagolysosomal membrane permeability with particle exposure

description: Inhalation of particles results in pulmonary inflammation; however, treatments are currently lacking. Docosahexaenoic acid (DHA) is an omega-3 polyunsaturated fatty acid shown to exhibit anti-inflammatory capabilities. The impact of DHA on particle-induced inflammation is unclear; therefore, the aim of this study was to examine the hypothesis that DHA downregulates macrophage inflammatory responses by altering phagolysosomal membrane permeability (LMP) and shifting macrophage phenotype. Isolated Balb/c alveolar macrophages (AM) were polarized into M1, M2a, M2b, or M2c phenotypes <i>in vitro</i>, treated with DHA, and exposed to a multi-walled carbon nanotube (MWNCT) or crystalline silica (SiO<sub>2</sub>). Results showed minimal cytotoxicity, robust effects for silica particle uptake, and LMP differences between phenotypes. Docosahexaenoic acid prevented these effects to the greatest extent in M2c phenotype. To determine if DHA affected inflammation similarly <i>in vivo</i>, Balb/c mice were placed on a control or 1% DHA diet for 3 weeks, instilled with the same particles, and assessed 24 hr following instillation. Data demonstrated that in contrast to <i>in vitro</i> findings, DHA increased pulmonary inflammation and LMP. These results suggest that pulmonary responses <i>in vivo</i> may not necessarily be predicted from single-cell responses <i>in vitro</i>.
DOI: 10.6084/m9.figshare.13193518
title: Docosahexaenoic acid impacts macrophage phenotype subsets and phagolysosomal membrane permeability with particle exposure

description: Inhalation of particles results in pulmonary inflammation; however, treatments are currently lacking. Docosahexaenoic acid (DHA) is an omega-3 polyunsaturated fatty acid shown to exhibit anti-inflammatory capabilities. The impact of DHA on particle-induced inflammation is unclear; therefore, the aim of this study was to examine the hypothesis that DHA downregulates macrophage inflammatory responses by altering phagolysosomal membrane permeability (LMP) and shifting macrophage phenotype. Isolated Balb/c alveolar macrophages (AM) were polarized into M1, M2a, M2b, or M2c phenotypes <i>in vitro</i>, treated with DHA, and exposed to a multi-walled carbon nanotube (MWNCT) or crystalline silica (SiO<sub>2</sub>). Results showed minimal cytotoxicity, robust effects for silica particle uptake, and LMP differences between phenotypes. Docosahexaenoic acid prevented these effects to the greatest extent in M2c phenotype. To determine if DHA affected inflammation similarly <i>in vivo</i>, Balb/c mice were placed on a control or 1% DHA diet for 3 weeks, instilled with the same particles, and assessed 24 hr following instillation. Data demonstrated that in contrast to <i>in vitro</i> findings, DHA increased pulmonary inflammation and LMP. These results suggest that pulmonary responses <i>in vivo</i> may not necessarily be predicted from single-cell responses <i>in vitro</i>.
DOI: 10.6084/m9.figshare.12848277
title: Toxicity evaluation and microbiota response of the lined sole Achirus lineatus (Chordata: Achiridae) exposed to the light petroleum water-accommodated fraction (WAF)

description: Exposure to contaminants might directly affect organisms and alter their associated microbiota. The objective of the present study was to determine the impact of the petroleum-water-accommodated fraction (WAF) from a light crude oil (API gravity 35) on a benthic fish species native from the Gulf of Mexico (GoM). Ten adults of <i>Achirus lineatus</i> (Linnaeus, 1758) were exposed to a sublethal WAF/water solution of 50% v/v for 48 hr. Multiple endpoints were measured including tissue damage, presence of polycyclic aromatic hydrocarbons (PAHs) metabolites in bile and gut microbiota analyses. Atrophy and fatty degeneration were observed in livers. Nodules and inflammation were detected in spleen, and structural disintegration and atrophy in the kidney. In gills hyperplasia, aneurysm, and gills lamellar fusion were observed. PAHs metabolites concentrations in bile were significantly higher in exposed organisms. Gut microbiome taxonomic analysis showed significant shifts in bacterial structure and composition following WAF exposure. Data indicate that exposure to WAF produced toxic effects in adults of <i>A. lineatus</i>, as evidenced by histological alterations and dysbiosis, which might represent an impairment to long-term subsistence of exposed aquatic organisms.
DOI: 10.6084/m9.figshare.12848277.v1
title: Toxicity evaluation and microbiota response of the lined sole Achirus lineatus (Chordata: Achiridae) exposed to the light petroleum water-accommodated fraction (WAF)

description: Exposure to contaminants might directly affect organisms and alter their associated microbiota. The objective of the present study was to determine the impact of the petroleum-water-accommodated fraction (WAF) from a light crude oil (API gravity 35) on a benthic fish species native from the Gulf of Mexico (GoM). Ten adults of <i>Achirus lineatus</i> (Linnaeus, 1758) were exposed to a sublethal WAF/water solution of 50% v/v for 48 hr. Multiple endpoints were measured including tissue damage, presence of polycyclic aromatic hydrocarbons (PAHs) metabolites in bile and gut microbiota analyses. Atrophy and fatty degeneration were observed in livers. Nodules and inflammation were detected in spleen, and structural disintegration and atrophy in the kidney. In gills hyperplasia, aneurysm, and gills lamellar fusion were observed. PAHs metabolites concentrations in bile were significantly higher in exposed organisms. Gut microbiome taxonomic analysis showed significant shifts in bacterial structure and composition following WAF exposure. Data indicate that exposure to WAF produced toxic effects in adults of <i>A. lineatus</i>, as evidenced by histological alterations and dysbiosis, which might represent an impairment to long-term subsistence of exposed aquatic organisms.
DOI: 10.5066/p93oy3dq
title: 09471580 - San Pedro River at St David, AZ - 2020/10/14 Terrestrial Lidar Data

description: This is a terrestrial LiDAR laser scanner dataset collected on October 14, 2020, in response to a flow event that occurred on September 8, 2020, at the USGS streamgage 09471580 - San Pedro River at St David, AZ. The reach scanned for this study is located at the bridge where State Route 80 crosses the waterway. A Leica MS-60 Multistation was used for the laser scanner data collection. Multiple scans were combined by setting up the scanner using resection techniques coupled with Leica RTK - GPS equipment. All scan data are corrected using measurements of a reference mark with a known location.
DOI: 10.21229/m9zt09
title: Seizure Detection Data
DOI: 10.5281/zenodo.4816493
title: Low-frequency seismic properties of olivine-orthopyroxene mixtures

description: Here are the dataset including experiment data, EBSD, SEM, and FTIR related to the manuscript 'Low-frequency seismic properties of olivine-orthopyroxene mixtures'.
DOI: 10.5281/zenodo.4816492
title: Low-frequency seismic properties of olivine-orthopyroxene mixtures

description: Here are the dataset including experiment data, EBSD, SEM, and FTIR related to the manuscript 'Low-frequency seismic properties of olivine-orthopyroxene mixtures'.