cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.7710566.v1
title: MicroRNAs: new biomarkers and promising therapeutic targets for diabetic kidney disease

description: Abstract Diabetic kidney disease (DKD) is a chronic complication of diabetes mellitus associated with significant morbidity and mortality regarded as a global health issue. MicroRNAs - small RNA molecules responsible for the post-transcriptional regulation of gene expression by degradation of messenger RNA or translational repression of protein synthesis - rank among the factors linked to the development and progression of DKD. This study aimed to offer a narrative review on investigations around the use of microRNAs in the diagnosis, monitoring, and treatment of DKD. Various microRNAs are involved in the pathogenesis of DKD, while others have a role in nephroprotection and thus serve as promising therapeutic targets for DKD. Serum and urine microRNAs levels have also been considered in the early diagnosis and monitoring of individuals with DKD, since increases in albuminuria, decreases in the glomerular filtration rate, and progression of DKD have been linked to changes in the levels of some microRNAs.
DOI: 10.6084/m9.figshare.7710569.v1
title: A Influência da Taxa de Câmbio e Renda Mundial Sobre as Exportações Brasileiras de Soja (2000-2015)

description: Abstract: This paper proposes to test the possible existence of a long-term relationship between the exchange rate and world income variables on the performance of Brazilian soybean exports. For this purpose, an econometric model capable of describing the level of sensitivity (elasticity) of the explanatory variables between January 2000 and December 2015 is estimated. The empirical strategy adopted was the use of time series methods, unit root test, Johansen cointegration test, autoregressive vector model (VAR), called error correction vector model (VECM), impulse-response function and the decomposition of variance prediction errors. The results showed that only the global income variable was relevant to explain the oscillations that occurred over time in the dependent soybean export variable, revealing the importance of the international scenario for the Brazilian sales of the commodity. The variable exchange rate showed a sign contrary to economic theory; however, it registered a significant coefficient. In the short-term analysis, it was observed that there is a certain time lag for short-term imbalances to be corrected in the long run.
DOI: 10.6084/m9.figshare.7710548
title: On the Euler-Heisenberg action and the light scattering by light

description: Abstract This work has as objective to present a review, with pedagogical and scientific divulgation purposes, about the developments on the subject of the light by light scattering and its relation with the Euler-Heisenberg effective action. We present initially a brief historical overview followed by discussion over the Euler-Heisenberg action in several contexts, but specially in two, Fock-Schwinger proper-time method and Lorentz violation symmetry. Finally we discuss the recent results obtained by the ATLAS collaboration of the LHC which point to an evidence of the light by light scattering.
DOI: 10.6084/m9.figshare.7710557
title: Antifungal susceptibility of yeasts isolated from anthropogenic watershed

description: Abstract Yeasts are unicellular fungi widespread in the environment, and studies suggest that there is a positive correlation between yeast and polluted aquatic environments. The aim of this study was to analyze the diversity and resistance of yeasts isolated from water samples collected along the Arroio Dilúvio in Porto Alegre to antifungals. Yeast isolates from the Arroio Dilúvio were subjected to susceptibility assays against antifungals using the minimum inhibitory concentration (MIC) test, and amplification of the ITS1-5.8S-IT2 region; in addition, the ITS-5.8S region was sequenced for some of the isolates. The amplification product was subjected to PCR-RFLP, and the restriction profile allowed the construction of a dendrogram. Susceptibility tests showed a high prevalence of resistance to azole antifungals, where 16.8% of the isolates had a resistance profile to amphotericin B. The sequence analysis allowed the identification of Candida species, including potentially pathogenic species, and species of the Debaryomyces spp. The resistance to antifungals in yeasts isolated from Arroio Dilúvio reinforces the importance of studies of environmental microbiota, and indicates that environmental degradation influences the phenotype displayed.
DOI: 10.7284/114344
title: GNSS (Global Navigation Satellite System) data collected during research cruise AT26-08 using a C&C C-Nav 2050G instrument system onboard the platform RV Atlantis

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7710554
title: A Configuração das Lógicas Institucionais do Campo da Cachaça de Alambique em Minas Gerais

description: Abstract: The organizational field of alembic cachaça in Minas Gerais is composed by different actors and social structures. This configuration underwent several transformations from the colonial period, marked by marginalized manufacturing and consumption, until nowadays, when the beverage has been consolidated as a symbol of the national culture. In certain segments, cachaça is included as a product of high social distinction and wide insertion in the international market. In this direction, this work aimed to describe the configuration of the institutional logics that constitute this organizational field. Initially, we sought to recover the socio-historical context of the drink through documentary sources and interviews with actors representing the organizations of the field. Next, we outlined four main logics that serve as reference for producers of alembic cachaça, namely: tradition, market, state and a technical-scientific logic. We described the main constituent elements of these logics, highlighting their assumptions and orientations in relation to symbolic and practice dimensions. Thus, it was possible to show how the institutional dynamics, especially from the emergence of technical-scientific logic, guided changes in the normative configuration of cachaça production and consumption.
DOI: 10.6084/m9.figshare.7710542
title: Drying kinetics of jabuticaba pulp by regression models

description: Abstract Jabuticaba tree is native to the Atlantic Forest in Southern Brazil, and its fruit is widely consumed in the fresh form, but it is highly perishable, requiring conservation techniques. The aim of this study was to describe the drying kinetics of jabuticaba pulp at temperatures of 50 and 60°C, comparing the Henderson, Simple Three-Parameter Exponential, Lewis, Thompson, Fick and Wang and Sing regression models and estimating the Absolute Drying Rate (ADR) for the best model. Parameters were estimated using the SAS software. The evaluation of the quality in the adjustment and selection of models was made based on the adjusted determination coefficient, Residual Standard Deviation and Akaike Information Criterion. Models presented good adjustment to data, and the Lewis model was the most suitable to describe the drying kinetics of jabuticaba pulp at temperatures of 50 and 60°C, with drying rate of 0.000063 and 0.000082 g of water/s respectively. ADR indicated that in one third of the drying time, 70% of moisture loss occurred at both temperatures and after this period, there was a deceleration of moisture loss until stabilization, when equilibrium moisture content is reached.
DOI: 10.6084/m9.figshare.7710545
title: Is it safe to shoot up? An analysis of the lethality of subsonic projectiles

description: Abstract Celebratory gunfire is the shooting of a firearm into the air in celebration. This is common in countries as Afghanistan, Pakistan and regions of Latin American. In this article, we have solved the problem of a projectile with subsonic speed shooted upward, considering the air resistance. For didactic purposes, we draw a parallel between the case with and without air resistance. We conclude that even small-caliber projectile can be lethal when falling, a despite the decrease in speed and kinetics energy.
DOI: 10.6084/m9.figshare.7710554.v1
title: A Configuração das Lógicas Institucionais do Campo da Cachaça de Alambique em Minas Gerais

description: Abstract: The organizational field of alembic cachaça in Minas Gerais is composed by different actors and social structures. This configuration underwent several transformations from the colonial period, marked by marginalized manufacturing and consumption, until nowadays, when the beverage has been consolidated as a symbol of the national culture. In certain segments, cachaça is included as a product of high social distinction and wide insertion in the international market. In this direction, this work aimed to describe the configuration of the institutional logics that constitute this organizational field. Initially, we sought to recover the socio-historical context of the drink through documentary sources and interviews with actors representing the organizations of the field. Next, we outlined four main logics that serve as reference for producers of alembic cachaça, namely: tradition, market, state and a technical-scientific logic. We described the main constituent elements of these logics, highlighting their assumptions and orientations in relation to symbolic and practice dimensions. Thus, it was possible to show how the institutional dynamics, especially from the emergence of technical-scientific logic, guided changes in the normative configuration of cachaça production and consumption.
DOI: 10.7284/114606
title: Meteorological Station data collected during research cruise AT26-08 using a Vaisala WXT520 instrument system onboard the platform RV Atlantis

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7710542.v1
title: Drying kinetics of jabuticaba pulp by regression models

description: Abstract Jabuticaba tree is native to the Atlantic Forest in Southern Brazil, and its fruit is widely consumed in the fresh form, but it is highly perishable, requiring conservation techniques. The aim of this study was to describe the drying kinetics of jabuticaba pulp at temperatures of 50 and 60°C, comparing the Henderson, Simple Three-Parameter Exponential, Lewis, Thompson, Fick and Wang and Sing regression models and estimating the Absolute Drying Rate (ADR) for the best model. Parameters were estimated using the SAS software. The evaluation of the quality in the adjustment and selection of models was made based on the adjusted determination coefficient, Residual Standard Deviation and Akaike Information Criterion. Models presented good adjustment to data, and the Lewis model was the most suitable to describe the drying kinetics of jabuticaba pulp at temperatures of 50 and 60°C, with drying rate of 0.000063 and 0.000082 g of water/s respectively. ADR indicated that in one third of the drying time, 70% of moisture loss occurred at both temperatures and after this period, there was a deceleration of moisture loss until stabilization, when equilibrium moisture content is reached.
DOI: 10.6084/m9.figshare.7710524
title: Acute toxicity of nitrate in Litopenaeus vannamei juveniles at low salinity levels

description: ABSTRACT: Different technologies have been developed to improve the performance of Litopenaeus vannamei in low salinity, mainly in super-intensive systems like recirculation and BFT (Biofloc Technology System) systems. However, there is an accumulation of toxic nitrogenous compounds to the shrimps such as nitrate, that at high concentrations and depending on the salinity of the culture water can be lethal. Acute toxicity tests allow to analyze the relationship between the compound and other abiotic or biotic variables. The aim of this research was to determine the acute toxicity and safety level of nitrate (N-NO3 -) for juveniles of L. vannamei at salinities of 5 and 10g.L-1. For salinity of 5g.L-1, a control and 5 treatments were tested, with nitrate concentrations of 100, 500, 1500, 2500 and 3500mg.L-1.For salinity of 10mg.L-1, a 4500mg.L-1nitrate concentration was added. Juveniles were exposed to concentrations during 24, 48, 72, 96 hours in static system. The Mean Lethal Concentration (LCC50) was calculated and the recommended safety level for L. vannamei cultivation is 60.05 and 127.61mg.L-1 of nitrate for salinities 5 and 10g.L-1, respectively.
DOI: 10.7284/114607
title: Meteorological Station data collected during research cruise AT26-08 using a Vaisala WXT520 instrument system onboard the platform RV Atlantis

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7710521
title: Nanoparticulate drug delivery systems for the treatment of neglected tropical protozoan diseases

description: Abstract Neglected Tropical Diseases (NTDs) comprise of a group of seventeen infectious conditions endemic in many developing countries. Among these diseases are three of protozoan origin, namely leishmaniasis, Chagas disease, and African trypanosomiasis, caused by the parasites Leishmania spp., Trypanosoma cruzi, and Trypanosoma brucei respectively. These diseases have their own unique challenges which are associated with the development of effective prevention and treatment methods. Collectively, these parasitic diseases cause more deaths worldwide than all other NTDs combined. Moreover, many current therapies for these diseases are limited in their efficacy, possessing harmful or potentially fatal side effects at therapeutic doses. It is therefore imperative that new treatment strategies for these parasitic diseases are developed. Nanoparticulate drug delivery systems have emerged as a promising area of research in the therapy and prevention of NTDs. These delivery systems provide novel mechanisms for targeted drug delivery within the host, maximizing therapeutic effects while minimizing systemic side effects. Currently approved drugs may also be repackaged using these delivery systems, allowing for their potential use in NTDs of protozoan origin. Current research on these novel delivery systems has provided insight into possible indications, with evidence demonstrating their improved ability to specifically target pathogens, penetrate barriers within the host, and reduce toxicity with lower dose regimens. In this review, we will examine current research on these delivery systems, focusing on applications in the treatment of leishmaniasis, Chagas disease, and African trypanosomiasis. Nanoparticulate systems present a unique therapeutic alternative through the repositioning of existing medications and directed drug delivery.
DOI: 10.6084/m9.figshare.7710524.v1
title: Acute toxicity of nitrate in Litopenaeus vannamei juveniles at low salinity levels

description: ABSTRACT: Different technologies have been developed to improve the performance of Litopenaeus vannamei in low salinity, mainly in super-intensive systems like recirculation and BFT (Biofloc Technology System) systems. However, there is an accumulation of toxic nitrogenous compounds to the shrimps such as nitrate, that at high concentrations and depending on the salinity of the culture water can be lethal. Acute toxicity tests allow to analyze the relationship between the compound and other abiotic or biotic variables. The aim of this research was to determine the acute toxicity and safety level of nitrate (N-NO3 -) for juveniles of L. vannamei at salinities of 5 and 10g.L-1. For salinity of 5g.L-1, a control and 5 treatments were tested, with nitrate concentrations of 100, 500, 1500, 2500 and 3500mg.L-1.For salinity of 10mg.L-1, a 4500mg.L-1nitrate concentration was added. Juveniles were exposed to concentrations during 24, 48, 72, 96 hours in static system. The Mean Lethal Concentration (LCC50) was calculated and the recommended safety level for L. vannamei cultivation is 60.05 and 127.61mg.L-1 of nitrate for salinities 5 and 10g.L-1, respectively.
DOI: 10.6084/m9.figshare.7710512
title: Body poem: poem body

description: Abstract This article discusses the photographic exposition titled Corpo-poema [Body-poem], drawing on concepts such as expanded field, post autonomy and unspecificity, seeking to understand both the creative and experiential artistic processes involved in this project, and the ways in which this work promotes the liberation of women’s bodies, as well as the restitution of literature and the body in public spaces. In a process in which body and word are repurposed, they both unsettle the literary institution and contribute to expanding the field of Brazilian contemporary literature.
DOI: 10.6084/m9.figshare.7710515
title: TOTAL OMENTECTOMY IN GASTRIC CANCER SURGERY: IS IT ALWAYS NECESSARY?

description: ABSTRACT Background: Traditionally, total omentectomy is performed along with gastric resection and extended lymphadenectomy in gastric cancer (GC) surgery. However, solid evidences regarding its oncologic benefit is still scarce. Aim: To evaluate the incidence of metastatic omental lymph nodes (LN) in patients undergoing curative gastrectomy for GC, as well as its risk factors and patients’ outcomes. Methods: All consecutive patients submitted to D2/modified D2 gastrectomy due to gastric adenocarcinoma from March 2009 to April 2016 were retrospectively reviewed from a prospective collected database. Results: Of 284 patients included, five (1.8%) patients had metastatic omental LN (one: pT3N3bM0; two: pT4aN3bM0; one: pT4aN2M0 and one pT4bN3bM0). Four of them deceased and one was under palliative chemotherapy due relapse. LN metastases in the greater omentum significantly correlated with tumor’s size (p=0.018), N stage (p&lt;0.001), clinical stage (p=0.022), venous invasion growth (p=0.003), recurrence (p=0.006), site of recurrence (peritoneum: p=0.008; liver: p=0.023; ovary: p=0.035) and death (p=0.008). Conclusion: The incidence of metastatic omental LN of patients undergoing radical gastrectomy due to GC is extremely low. Total omentectomy may be avoided in tumors smaller than 5.25 cm and T1/T2 tumors. However, the presence of lymph node metastases in the greater omentum is associated with recurrence in the peritoneum, liver, ovary and death.
DOI: 10.6084/m9.figshare.7710518
title: Implicações Sociais, Econômicas e Ambientais de Uma Iniciativa de Manejo Florestal Comunitário em Assentamento na Amazônia Oriental

description: Abstract: This study aimed to understand the connections among participation in community forest management (CFM), plot turnover, household income and deforestation. The empirical research was carried out in an environmentally focused land reform settlement near the Transamazon highway, the Virola-Jatobá Sustainable Development Project (PDS) in the municipality of Anapu, Pará state, Brazil. In this settlement, CFM has been for over a decade a major governmental instrument to curb deforestation, avoid land turnover and improve income. Our analysis of a community-company agreement for forest management shows that resources derived from the sale of timber were unable to reduce spatial mobility, control deforestation and provide sustainable livelihoods. Direct observation in anthropological action research shows that CFM will only succeed if resulting from collective action assembling the diverse and divergent social groups in the PDS. We also identified that specific social norms related to swidden, slash-and-burn fields have the potential to generate collective action, even towards forest management. Considering the local diversity of actors and complexity of contexts, we conclude that the adjustment of social norms connecting swidden fields to forest management is a critical condition for the effectiveness of CFM and the environmental land reform modality.
DOI: 10.6084/m9.figshare.7710518.v1
title: Implicações Sociais, Econômicas e Ambientais de Uma Iniciativa de Manejo Florestal Comunitário em Assentamento na Amazônia Oriental

description: Abstract: This study aimed to understand the connections among participation in community forest management (CFM), plot turnover, household income and deforestation. The empirical research was carried out in an environmentally focused land reform settlement near the Transamazon highway, the Virola-Jatobá Sustainable Development Project (PDS) in the municipality of Anapu, Pará state, Brazil. In this settlement, CFM has been for over a decade a major governmental instrument to curb deforestation, avoid land turnover and improve income. Our analysis of a community-company agreement for forest management shows that resources derived from the sale of timber were unable to reduce spatial mobility, control deforestation and provide sustainable livelihoods. Direct observation in anthropological action research shows that CFM will only succeed if resulting from collective action assembling the diverse and divergent social groups in the PDS. We also identified that specific social norms related to swidden, slash-and-burn fields have the potential to generate collective action, even towards forest management. Considering the local diversity of actors and complexity of contexts, we conclude that the adjustment of social norms connecting swidden fields to forest management is a critical condition for the effectiveness of CFM and the environmental land reform modality.
DOI: 10.6084/m9.figshare.7710521.v1
title: Nanoparticulate drug delivery systems for the treatment of neglected tropical protozoan diseases

description: Abstract Neglected Tropical Diseases (NTDs) comprise of a group of seventeen infectious conditions endemic in many developing countries. Among these diseases are three of protozoan origin, namely leishmaniasis, Chagas disease, and African trypanosomiasis, caused by the parasites Leishmania spp., Trypanosoma cruzi, and Trypanosoma brucei respectively. These diseases have their own unique challenges which are associated with the development of effective prevention and treatment methods. Collectively, these parasitic diseases cause more deaths worldwide than all other NTDs combined. Moreover, many current therapies for these diseases are limited in their efficacy, possessing harmful or potentially fatal side effects at therapeutic doses. It is therefore imperative that new treatment strategies for these parasitic diseases are developed. Nanoparticulate drug delivery systems have emerged as a promising area of research in the therapy and prevention of NTDs. These delivery systems provide novel mechanisms for targeted drug delivery within the host, maximizing therapeutic effects while minimizing systemic side effects. Currently approved drugs may also be repackaged using these delivery systems, allowing for their potential use in NTDs of protozoan origin. Current research on these novel delivery systems has provided insight into possible indications, with evidence demonstrating their improved ability to specifically target pathogens, penetrate barriers within the host, and reduce toxicity with lower dose regimens. In this review, we will examine current research on these delivery systems, focusing on applications in the treatment of leishmaniasis, Chagas disease, and African trypanosomiasis. Nanoparticulate systems present a unique therapeutic alternative through the repositioning of existing medications and directed drug delivery.