cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.15468/dl.r5p3pu
title: Occurrence Download

description: A dataset containing 44 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Epitrix tuberis Gentner, 1944)",
 "HasCoordinate is true"
 ]
}

 The dataset includes 44 records from 6 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0026364-240506114902167/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.hssxqm
title: Occurrence Download

description: A dataset containing 3368 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Continent is Africa",
 "Country is Nigeria",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 "TaxonKey is Rodentia"
 ]
}

 The dataset includes 3368 records from 19 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0026365-240506114902167/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.hw5qs2
title: Occurrence Download

description: A dataset containing 18112 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Poecilia latipinna (Lesueur, 1821))",
 "HasCoordinate is true"
 ]
}

 The dataset includes 18112 records from 75 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0026362-240506114902167/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.my3bq7
title: Occurrence Download

description: A dataset containing 683 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Epitrix hirtipennis (Melsheimer, 1847))",
 "HasCoordinate is true"
 ]
}

 The dataset includes 683 records from 34 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0026367-240506114902167/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.2uvrsh
title: Occurrence Download

description: A dataset containing 437 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Poecilia velifera (Regan, 1914))",
 "HasCoordinate is true"
 ]
}

 The dataset includes 437 records from 28 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0026368-240506114902167/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.b74y5g
title: Occurrence Download

description: A dataset containing 69 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Epitrix similaris Gentner, 1944)",
 "HasCoordinate is true"
 ]
}

 The dataset includes 69 records from 7 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0026369-240506114902167/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.6084/m9.figshare.1380304
title: Spatio-temporal regulation of the human licensing factor Cdc6 in replication and mitosis

description: To maintain genome stability, the thousands of replication origins of mammalian genomes must only initiate replication once per cell cycle. This is achieved by a strict temporal separation of ongoing replication in S phase, and the formation of pre-replicative complexes in the preceding G1 phase, which "licenses" each origin competent for replication. The contribution of the loading factor Cdc6 to the timing of the licensing process remained however elusive due to seemingly contradictory findings concerning stabilization, degradation and nuclear export of Cdc6. Using fluorescently tagged Cdc6 (Cdc6-YFP) expressed in living cycling cells, we demonstrate here that Cdc6-YFP is stable and chromatin-associated during mitosis and G1 phase. It undergoes rapid proteasomal degradation during S phase initiation followed by active export to the cytosol during S and G2 phases. Biochemical fractionation abolishes this nuclear exclusion, causing aberrant chromatin association of Cdc6-YFP and, likely, endogenous Cdc6, too. In addition, we demonstrate association of Cdc6 with centrosomes in late G2 and during mitosis. These results show that multiple Cdc6-regulatory mechanisms coexist but are tightly controlled in a cell cycle-specific manner.
DOI: 10.6084/m9.figshare.1312958
title: Ubiquitin-H2AX fusions render 53BP1 recruitment to DNA damage sites independent of RNF8 or RNF168

description: The mammalian E3 ubiquitin ligases RNF8 and RNF168 facilitate recruitment of the DNA damage response protein 53BP1 to sites of DNA double-strand breaks (DSBs). The mechanism involves recruitment of RNF8, followed by recruitment of RNF168, which ubiquitinates histones H2A/H2AX on K15. 53BP1 then binds to nucleosomes at sites of DNA DSBs by recognizing, in addition to methyl marks, histone H2A/H2AX ubiquitinated on K15. We report here that expressing H2AX fusion proteins with N-terminal bulky moieties can rescue 53BP1 recruitment to sites of DNA DSBs in cells lacking RNF8 or RNF168 or in cells treated with proteasome inhibitors, in which histone ubiquitination at sites of DNA DSBs is compromised. The rescue required S139 at the C-terminus of the H2AX fusion protein and was occasionally accompanied by partial rescue of ubiquitination at sites of DNA DSBs. We conclude that recruitment of 53BP1 to sites of DNA DSBs is possible in the absence of RNF8 or RNF168, but still dependent on chromatin ubiquitination.
DOI: 10.6084/m9.figshare.1312958.v3
title: Ubiquitin-H2AX fusions render 53BP1 recruitment to DNA damage sites independent of RNF8 or RNF168

description: The mammalian E3 ubiquitin ligases RNF8 and RNF168 facilitate recruitment of the DNA damage response protein 53BP1 to sites of DNA double-strand breaks (DSBs). The mechanism involves recruitment of RNF8, followed by recruitment of RNF168, which ubiquitinates histones H2A/H2AX on K15. 53BP1 then binds to nucleosomes at sites of DNA DSBs by recognizing, in addition to methyl marks, histone H2A/H2AX ubiquitinated on K15. We report here that expressing H2AX fusion proteins with N-terminal bulky moieties can rescue 53BP1 recruitment to sites of DNA DSBs in cells lacking RNF8 or RNF168 or in cells treated with proteasome inhibitors, in which histone ubiquitination at sites of DNA DSBs is compromised. The rescue required S139 at the C-terminus of the H2AX fusion protein and was occasionally accompanied by partial rescue of ubiquitination at sites of DNA DSBs. We conclude that recruitment of 53BP1 to sites of DNA DSBs is possible in the absence of RNF8 or RNF168, but still dependent on chromatin ubiquitination.
DOI: 10.6084/m9.figshare.1312958.v4
title: Ubiquitin-H2AX fusions render 53BP1 recruitment to DNA damage sites independent of RNF8 or RNF168

description: The mammalian E3 ubiquitin ligases RNF8 and RNF168 facilitate recruitment of the DNA damage response protein 53BP1 to sites of DNA double-strand breaks (DSBs). The mechanism involves recruitment of RNF8, followed by recruitment of RNF168, which ubiquitinates histones H2A/H2AX on K15. 53BP1 then binds to nucleosomes at sites of DNA DSBs by recognizing, in addition to methyl marks, histone H2A/H2AX ubiquitinated on K15. We report here that expressing H2AX fusion proteins with N-terminal bulky moieties can rescue 53BP1 recruitment to sites of DNA DSBs in cells lacking RNF8 or RNF168 or in cells treated with proteasome inhibitors, in which histone ubiquitination at sites of DNA DSBs is compromised. The rescue required S139 at the C-terminus of the H2AX fusion protein and was occasionally accompanied by partial rescue of ubiquitination at sites of DNA DSBs. We conclude that recruitment of 53BP1 to sites of DNA DSBs is possible in the absence of RNF8 or RNF168, but still dependent on chromatin ubiquitination.
DOI: 10.6084/m9.figshare.1380304.v5
title: Spatio-temporal regulation of the human licensing factor Cdc6 in replication and mitosis

description: To maintain genome stability, the thousands of replication origins of mammalian genomes must only initiate replication once per cell cycle. This is achieved by a strict temporal separation of ongoing replication in S phase, and the formation of pre-replicative complexes in the preceding G1 phase, which "licenses" each origin competent for replication. The contribution of the loading factor Cdc6 to the timing of the licensing process remained however elusive due to seemingly contradictory findings concerning stabilization, degradation and nuclear export of Cdc6. Using fluorescently tagged Cdc6 (Cdc6-YFP) expressed in living cycling cells, we demonstrate here that Cdc6-YFP is stable and chromatin-associated during mitosis and G1 phase. It undergoes rapid proteasomal degradation during S phase initiation followed by active export to the cytosol during S and G2 phases. Biochemical fractionation abolishes this nuclear exclusion, causing aberrant chromatin association of Cdc6-YFP and, likely, endogenous Cdc6, too. In addition, we demonstrate association of Cdc6 with centrosomes in late G2 and during mitosis. These results show that multiple Cdc6-regulatory mechanisms coexist but are tightly controlled in a cell cycle-specific manner.
DOI: 10.6084/m9.figshare.1408675
title: Let-7a regulates mammosphere formation capacity through Ras/NF-κB and Ras/MAPK/ERK pathway in breast cancer stem cells

description: Breast cancer stem cells (BCSCs) have the greatest potential to maintain tumorigenesis in all subtypes of tumor cells and were regarded as the key drivers of tumor. Recent evidence has demonstrated that BCSCs contributed to a high degree of resistance to therapy. However, how BCSCs self renewal and tumorigenicity are maintained remains obscure. Herein, our study illustrated that overexpression of let-7a reduced cell proliferation and mammosphere formation ability of breast cancer stem cells(BCSCs) in a KRas-dependent manner through different pathways in vitro and in vivo. To be specific, we provided the evidence that let-7a was decreased, and reversely the expression of KRas was increased with moderate expression in early stages (I/II) and high expression in advanced stages (III/IV) in breast cancer specimens. In addition, the negative correlation between let-7a and KRas was clearly observed. In vitro, we found that let-7a inhibited mammosphere-forming efficiency and the mammosphere-size via NF-κB and MAPK/ERK pathway, respectively. The inhibitory effect of let-7a on mammosphere formation efficiency and the size of mammospheres was abolished after the depletion of KRas. On the contrary, enforced expression of KRas rescued the effect of let-7a. In vivo, let-7a inhibited the growth of tumors, whereas the negative effect of let-7a was rescued after overexpressing KRas. Taken together, our findings suggested that let-7a played a tumor suppressive role in a KRas-dependent manner.
DOI: 10.6084/m9.figshare.1408675.v3
title: Let-7a regulates mammosphere formation capacity through Ras/NF-κB and Ras/MAPK/ERK pathway in breast cancer stem cells

description: Breast cancer stem cells (BCSCs) have the greatest potential to maintain tumorigenesis in all subtypes of tumor cells and were regarded as the key drivers of tumor. Recent evidence has demonstrated that BCSCs contributed to a high degree of resistance to therapy. However, how BCSCs self renewal and tumorigenicity are maintained remains obscure. Herein, our study illustrated that overexpression of let-7a reduced cell proliferation and mammosphere formation ability of breast cancer stem cells(BCSCs) in a KRas-dependent manner through different pathways in vitro and in vivo. To be specific, we provided the evidence that let-7a was decreased, and reversely the expression of KRas was increased with moderate expression in early stages (I/II) and high expression in advanced stages (III/IV) in breast cancer specimens. In addition, the negative correlation between let-7a and KRas was clearly observed. In vitro, we found that let-7a inhibited mammosphere-forming efficiency and the mammosphere-size via NF-κB and MAPK/ERK pathway, respectively. The inhibitory effect of let-7a on mammosphere formation efficiency and the size of mammospheres was abolished after the depletion of KRas. On the contrary, enforced expression of KRas rescued the effect of let-7a. In vivo, let-7a inhibited the growth of tumors, whereas the negative effect of let-7a was rescued after overexpressing KRas. Taken together, our findings suggested that let-7a played a tumor suppressive role in a KRas-dependent manner.
DOI: 10.6084/m9.figshare.1380304.v4
title: Spatio-temporal regulation of the human licensing factor Cdc6 in replication and mitosis

description: To maintain genome stability, the thousands of replication origins of mammalian genomes must only initiate replication once per cell cycle. This is achieved by a strict temporal separation of ongoing replication in S phase, and the formation of pre-replicative complexes in the preceding G1 phase, which "licenses" each origin competent for replication. The contribution of the loading factor Cdc6 to the timing of the licensing process remained however elusive due to seemingly contradictory findings concerning stabilization, degradation and nuclear export of Cdc6. Using fluorescently tagged Cdc6 (Cdc6-YFP) expressed in living cycling cells, we demonstrate here that Cdc6-YFP is stable and chromatin-associated during mitosis and G1 phase. It undergoes rapid proteasomal degradation during S phase initiation followed by active export to the cytosol during S and G2 phases. Biochemical fractionation abolishes this nuclear exclusion, causing aberrant chromatin association of Cdc6-YFP and, likely, endogenous Cdc6, too. In addition, we demonstrate association of Cdc6 with centrosomes in late G2 and during mitosis. These results show that multiple Cdc6-regulatory mechanisms coexist but are tightly controlled in a cell cycle-specific manner.
DOI: 10.15468/dl.dkwpd9
title: Occurrence Download

description: A dataset containing 158 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Poecilia latipunctata Meek, 1904)",
 "HasCoordinate is true"
 ]
}

 The dataset includes 158 records from 23 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0026371-240506114902167/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.39agvg
title: Occurrence Download

description: A dataset containing 965 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Epitrix cucumeris (Harris, 1851))",
 "HasCoordinate is true"
 ]
}

 The dataset includes 965 records from 35 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0026372-240506114902167/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.u8u2g5
title: Occurrence Download

description: A dataset listing the 102 species recorded in GBIF matching the query:
{
 "and" : [
 "Continent is Africa",
 "Country is Nigeria",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 "TaxonKey is Rodentia"
 ]
}

 The dataset's 102 records were derived from 19 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0026366-240506114902167/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.z2334c
title: Occurrence Download

description: A dataset containing 24645 species occurrences available in GBIF matching the query:
{
 "and" : [
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 "TaxonKey is Montifringilla nivalis (Linnaeus, 1766)"
 ]
}

 The dataset includes 24645 records from 210 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0026373-240506114902167/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.kjrqgw
title: Occurrence Download

description: A dataset containing 7128 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Argopleura magdalenensis (Eigenmann, 1913)"
 ]
}

 The dataset includes 7128 records from 31 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0396845-210914110416597/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.dzvzzk
title: Occurrence Download

description: A dataset containing 145 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is China",
 "TaxonKey is Pennisetum longissimum S.L.Chen & Y.X.Jin"
 ]
}

 The dataset includes 145 records from 10 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0083748-230224095556074/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.25549/pcra-c14-29123
title: Correspondence book No. 3 of Pentecostal Missionary Union [PMU], 1921

description: [description english/roman)] Pentecostal Missionary Union [PMU] Correspondence book No. 3 including 31 pages of subject index; 1006 pages of PMU outgoing correspondence.
DOI: 10.15468/dl.ak3d5x
title: Occurrence Download

description: A dataset containing 2996 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Geometry POLYGON ((-79.9190420000000046 40.4334717999999995, -79.9190420000000046 40.4341569899999982, -79.9190420000000046 40.4352532799999977, -79.9190420000000046 40.4359841500000030, -79.9190420000000046 40.4371718000000016, -79.9190420000000046 40.4380396999999974, -79.9178528700000044 40.4380396999999974, -79.9168008900000046 40.4380396999999974, -79.9153372600000012 40.4380396999999974, -79.9141480699999960 40.4380396999999974, -79.9132790400000061 40.4380396999999974, -79.9123185400000011 40.4380396999999974, -79.9116324600000070 40.4380396999999974, -79.9106719600000019 40.4380396999999974, -79.9098486700000024 40.4380396999999974, -79.9086137999999977 40.4380396999999974, -79.9086137999999977 40.4368520499999988, -79.9086137999999977 40.4363038999999986, -79.9086137999999977 40.4352989599999972, -79.9086137999999977 40.4347508099999970, -79.9086137999999977 40.4339742700000002, -79.9086137999999977 40.4334717999999995, -79.9095742399999978 40.4334717999999995, -79.9103975299999973 40.4334717999999995, -79.9110836100000057 40.4334717999999995, -79.9119526300000018 40.4334717999999995, -79.9126387099999960 40.4334717999999995, -79.9136906899999957 40.4334717999999995, -79.9143767599999961 40.4334717999999995, -79.9153830000000056 40.4334717999999995, -79.9163434999999964 40.4334717999999995, -79.9173040099999952 40.4334717999999995, -79.9183559899999949 40.4334717999999995, -79.9190420000000046 40.4334717999999995))",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "Year is greater than or equal to 1932",
 "BasisOfRecord is one of (Human Observation, Living Specimen, Observation, Specimen, Machine Observation)"
 ]
}

 The dataset includes 2996 records from 6 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0099901-210914110416597/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.cmy8sj
title: Occurrence Download

description: A dataset containing 67 species occurrences available in GBIF matching the query:
{
 "and" : [
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "TaxonKey is Herpetospermum pedunculosum (Ser.) C.B.Clarke"
 ]
}

 The dataset includes 67 records from 10 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0125066-220831081235567/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.va9fsv
title: Occurrence Download

description: A dataset containing 93 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Leptopelis boulengeri (Werner, 1898))",
 "BasisOfRecord is one of (Specimen, Human Observation, Observation, Machine Observation)",
 "HasCoordinate is true",
 "HasGeospatialIssue is false"
 ]
}

 The dataset includes 93 records from 13 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0083794-230224095556074/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.jprzwj
title: Occurrence Download

description: A dataset containing 2 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is Benin",
 "TaxonKey is Pentas lanceolata (Forssk.) Deflers"
 ]
}

 The dataset includes 2 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0134251-210914110416597/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.25549/pcra-c14-29078
title: Correspondence book No. 3 of Pentecostal Missionary Union [PMU], 1921

description: [description english/roman)] Pentecostal Missionary Union [PMU] Correspondence book No. 3 including 31 pages of subject index; 1006 pages of PMU outgoing correspondence.
DOI: 10.15468/dl.hyg9kg
title: Occurrence Download

description: A dataset containing 1216 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Acrocephalus griseldis (Hartlaub, 1891)"
 ]
}

 The dataset includes 1216 records from 21 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0396841-210914110416597/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.7fbxjf
title: Occurrence Download

description: A dataset containing 992 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Chaenostoma cordatum Benth.",
 "HasCoordinate is true",
 "Year is greater than or equal to 1900",
 "BasisOfRecord is one of (Human Observation, Specimen, Unknown evidence)"
 ]
}

 The dataset includes 992 records from 38 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0083800-230224095556074/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.25549/pcra-c14-28814
title: Correspondence book No. 2 of Pentecostal Missionary Union [PMU], 1920-1921

description: [description english/roman)] Pentecostal Missionary Union [PMU] Correspondence book No. 2 including 31 pages of subject index; 1007 pages of PMU outgoing correspondence.
DOI: 10.15468/dl.hv4y5t
title: Occurrence Download

description: A dataset containing 200 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Munidopsis erinacea (A.Milne-Edwards, 1880)"
 ]
}

 The dataset includes 200 records from 19 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0125070-220831081235567/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.xcq4qt
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Leptopelis brevipes (Boulenger, 1906))",
 "BasisOfRecord is one of (Specimen, Human Observation, Observation, Machine Observation)",
 "HasCoordinate is true",
 "HasGeospatialIssue is false"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0083790-230224095556074/datasets/export for details.