cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.6350678.v1
title: Box-ticking and Olympic high jumping – Physicians’ perceptions and acceptance of national physician validation systems

description: <b>Purpose:</b> National physician validation systems aim to ensure lifelong learning through periodic appraisals of physicians’ competence. Their effectiveness is determined by physicians’ acceptance of and commitment to the system. This study, therefore, sought to explore physicians’ perceptions and self-reported acceptance of validation across three different physician validation systems in Europe. <b>Materials and methods:</b> Using a constructivist grounded-theory approach, we conducted semi-structured interviews with 32 respiratory specialists from three countries with markedly different validation systems: Germany, which has a mandatory, credit-based system oriented to continuing professional development; Denmark, with mandatory annual dialogs and ensuing, non-compulsory activities; and the UK, with a mandatory, portfolio-based revalidation system. We analyzed interview data with a view to identifying factors influencing physicians’ perceptions and acceptance. <b>Results:</b> Factors that influenced acceptance were the assessment’s authenticity and alignment of its requirements with clinical practice, physicians’ beliefs about learning, perceived autonomy, and organizational support. <b>Conclusions:</b> Users’ acceptance levels determine any system’s effectiveness. To support lifelong learning effectively, national physician validation systems must be carefully designed and integrated into daily practice. Involving physicians in their design may render systems more authentic and improve alignment between individual ambitions and the systems’ goals, thereby promoting acceptance.
DOI: 10.6084/m9.figshare.6350558
title: Coffee polyphenols prevent cognitive dysfunction and suppress amyloid β plaques in APP/PS2 transgenic mousem

description: Epidemiological studies have found that habitual coffee consumption may reduce the risk of Alzheimer’s disease. Coffee contains numerous phenolic compounds (coffee polyphenols) such as chlorogenic acids. However, evidence demonstrating the contribution of chlorogenic acids to the prevention of cognitive dysfunction induced by Alzheimer’s disease is limited. The present study investigated the effect of chlorogenic acids on the prevention of cognitive dysfunction in APP/PS2 transgenic mouse model of Alzheimer’s disease. Five-week-old APP/PS2 mice were administered a diet supplemented with coffee polyphenols daily for 5 months. The memory and cognitive function of mice was determined using the novel object recognition test, the Morris water maze test, and the step-through passive avoidance test. Immunohistochemical analysis revealed that chronic treatment with coffee polyphenols prevented cognitive dysfunction and significantly reduced the amount of Aβ plaques in the hippocampus. We then determined that 5-caffeoylquinic acid, one of the primary components of coffee polyphenols, did not inhibit Aβ fibrillation but degraded Aβ fibrils. In conclusion, our results demonstrate that coffee polyphenols prevent cognitive deficits and reduce Aβ plaque deposition via disaggregation of Aβ in the APP/PS2 mouse.
DOI: 10.6084/m9.figshare.6350558.v1
title: Untitled IteCoffee polyphenols prevent cognitive dysfunction and suppress amyloid β plaques in APP/PS2 transgenic mousem

description: Epidemiological studies have found that habitual coffee consumption may reduce the risk of Alzheimer’s disease. Coffee contains numerous phenolic compounds (coffee polyphenols) such as chlorogenic acids. However, evidence demonstrating the contribution of chlorogenic acids in preventing cognitive dysfunction induced by Alzheimer’s disease is limited. In this study, we investigated the effect of chlorogenic acids on prevention of cognitive dysfunction in APP/PS2 transgenic mouse model of Alzheimer’s disease. Five-week-old APP/PS2 mice were administered a diet supplemented with coffee polyphenols daily for 5 months. The memory and cognitive function of mice was determined using the novel object recognition test, the Morris water maze test, and the step-through passive avoidance test. We found that chronic treatment with coffee polyphenols prevented cognitive dysfunction and significantly reduced hippocampal Aβ deposition. We then determined the effect of 5-caffeoylquinic acid, one of the primary components of coffee polyphenols, on Aβ formation. 5-Caffeoylquinic acid did not inhibit Aβ fibrillation, but degraded Aβ fibrils in a dose-dependent manner. In conclusion, these results demonstrate that coffee polyphenols prevented cognitive deficits and alleviated Aβ plaque deposition via disaggregation of Aβ in APP/PS2 mouse.
DOI: 10.6084/m9.figshare.6350558.v3
title: Coffee polyphenols prevent cognitive dysfunction and suppress amyloid β plaques in APP/PS2 transgenic mousem

description: Epidemiological studies have found that habitual coffee consumption may reduce the risk of Alzheimer’s disease. Coffee contains numerous phenolic compounds (coffee polyphenols) such as chlorogenic acids. However, evidence demonstrating the contribution of chlorogenic acids to the prevention of cognitive dysfunction induced by Alzheimer’s disease is limited. The present study investigated the effect of chlorogenic acids on the prevention of cognitive dysfunction in APP/PS2 transgenic mouse model of Alzheimer’s disease. Five-week-old APP/PS2 mice were administered a diet supplemented with coffee polyphenols daily for 5 months. The memory and cognitive function of mice was determined using the novel object recognition test, the Morris water maze test, and the step-through passive avoidance test. Immunohistochemical analysis revealed that chronic treatment with coffee polyphenols prevented cognitive dysfunction and significantly reduced the amount of Aβ plaques in the hippocampus. We then determined that 5-caffeoylquinic acid, one of the primary components of coffee polyphenols, did not inhibit Aβ fibrillation but degraded Aβ fibrils. In conclusion, our results demonstrate that coffee polyphenols prevent cognitive deficits and reduce Aβ plaque deposition via disaggregation of Aβ in the APP/PS2 mouse.
DOI: 10.6084/m9.figshare.6350498
title: Additional file 6: of Dietary aquaculture by-product hydrolysates: impact on the transcriptomic response of the intestinal mucosa of European seabass (Dicentrarchus labrax) fed low fish meal diets

description: IPA analysis: list of main pathways impacted by hydrolysate and high fish meal diets compared to low fish meal diet. (XLSX 57 kb)
DOI: 10.6084/m9.figshare.6350558.v2
title: Coffee polyphenols prevent cognitive dysfunction and suppress amyloid β plaques in APP/PS2 transgenic mousem

description: Epidemiological studies have found that habitual coffee consumption may reduce the risk of Alzheimer’s disease. Coffee contains numerous phenolic compounds (coffee polyphenols) such as chlorogenic acids. However, evidence demonstrating the contribution of chlorogenic acids in preventing cognitive dysfunction induced by Alzheimer’s disease is limited. In this study, we investigated the effect of chlorogenic acids on prevention of cognitive dysfunction in APP/PS2 transgenic mouse model of Alzheimer’s disease. Five-week-old APP/PS2 mice were administered a diet supplemented with coffee polyphenols daily for 5 months. The memory and cognitive function of mice was determined using the novel object recognition test, the Morris water maze test, and the step-through passive avoidance test. We found that chronic treatment with coffee polyphenols prevented cognitive dysfunction and significantly reduced hippocampal Aβ deposition. We then determined the effect of 5-caffeoylquinic acid, one of the primary components of coffee polyphenols, on Aβ formation. 5-Caffeoylquinic acid did not inhibit Aβ fibrillation, but degraded Aβ fibrils in a dose-dependent manner. In conclusion, these results demonstrate that coffee polyphenols prevented cognitive deficits and alleviated Aβ plaque deposition via disaggregation of Aβ in APP/PS2 mouse.
DOI: 10.6084/m9.figshare.6350498.v1
title: Additional file 6: of Dietary aquaculture by-product hydrolysates: impact on the transcriptomic response of the intestinal mucosa of European seabass (Dicentrarchus labrax) fed low fish meal diets

description: IPA analysis: list of main pathways impacted by hydrolysate and high fish meal diets compared to low fish meal diet. (XLSX 57 kb)
DOI: 10.6084/m9.figshare.6350495
title: Additional file 5: of Dietary aquaculture by-product hydrolysates: impact on the transcriptomic response of the intestinal mucosa of European seabass (Dicentrarchus labrax) fed low fish meal diets

description: KEGG analysis: list of genes differentially expressed by hydrolysate and high fish meal diets compared to low fish meal diet. (XLSX 63 kb)
DOI: 10.6084/m9.figshare.6350495.v1
title: Additional file 5: of Dietary aquaculture by-product hydrolysates: impact on the transcriptomic response of the intestinal mucosa of European seabass (Dicentrarchus labrax) fed low fish meal diets

description: KEGG analysis: list of genes differentially expressed by hydrolysate and high fish meal diets compared to low fish meal diet. (XLSX 63 kb)
DOI: 10.5281/zenodo.4007786
title: Dataset for the manuscript titled "Assessment of Anti-Tuberculosis Medication Adherence and Associated Factors among Patients attending the Sokoto Specialist Hospital Tuberculosis Treatment Center, Nigeria – 2019".

description: Dataset of the research entitled "Assessment of Anti-Tuberculosis Medication Adherence and Associated Factors among Patients attending the Sokoto Specialist Hospital Tuberculosis Treatment Center, Nigeria – 2019".
description: Any difficulty with column labels can be addressed by sending an email to fsnuvey@gmail.com
DOI: 10.6084/m9.figshare.6350489
title: Additional file 3: of Dietary aquaculture by-product hydrolysates: impact on the transcriptomic response of the intestinal mucosa of European seabass (Dicentrarchus labrax) fed low fish meal diets

description: Global list and fold changes of differentially expressed genes versus FM20. Values correspond to fold changes between hydrolysate diets and the high fish meal control diet. Positive values indicate upregulation, and negative values down regulation. (XLSX 10 kb)
DOI: 10.5281/zenodo.4007785
title: Dataset for the manuscript titled "Assessment of Anti-Tuberculosis Medication Adherence and Associated Factors among Patients attending the Sokoto Specialist Hospital Tuberculosis Treatment Center, Nigeria – 2019".

description: Dataset of the research entitled "Assessment of Anti-Tuberculosis Medication Adherence and Associated Factors among Patients attending the Sokoto Specialist Hospital Tuberculosis Treatment Center, Nigeria – 2019".
description: Any difficulty with column labels can be addressed by sending an email to fsnuvey@gmail.com
DOI: 10.6084/m9.figshare.6350489.v1
title: Additional file 3: of Dietary aquaculture by-product hydrolysates: impact on the transcriptomic response of the intestinal mucosa of European seabass (Dicentrarchus labrax) fed low fish meal diets

description: Global list and fold changes of differentially expressed genes versus FM20. Values correspond to fold changes between hydrolysate diets and the high fish meal control diet. Positive values indicate upregulation, and negative values down regulation. (XLSX 10 kb)
DOI: 10.6084/m9.figshare.6350483
title: Additional file 2: of Dietary aquaculture by-product hydrolysates: impact on the transcriptomic response of the intestinal mucosa of European seabass (Dicentrarchus labrax) fed low fish meal diets

description: Global list and fold changes of differentially expressed genes versus FM5. Values correspond to fold changes between diets and the low fish meal control diet. Positive values indicate upregulation, and negative values down regulation. FM5, 5% fish meal diet; FM20, 20% fish meal diet; TH, tilapia hydrolysate diet; SH, shrimp hydrolysate diet; MH, mixed hydrolysate diet. Values with “*” correspond to fold change means of isoforms. If isoforms were at the same time up and down regulated each values appear. (XLSX 37 kb)
DOI: 10.6084/m9.figshare.6350483.v1
title: Additional file 2: of Dietary aquaculture by-product hydrolysates: impact on the transcriptomic response of the intestinal mucosa of European seabass (Dicentrarchus labrax) fed low fish meal diets

description: Global list and fold changes of differentially expressed genes versus FM5. Values correspond to fold changes between diets and the low fish meal control diet. Positive values indicate upregulation, and negative values down regulation. FM5, 5% fish meal diet; FM20, 20% fish meal diet; TH, tilapia hydrolysate diet; SH, shrimp hydrolysate diet; MH, mixed hydrolysate diet. Values with “*” correspond to fold change means of isoforms. If isoforms were at the same time up and down regulated each values appear. (XLSX 37 kb)
DOI: 10.6084/m9.figshare.6350480
title: Additional file 1: of Dietary aquaculture by-product hydrolysates: impact on the transcriptomic response of the intestinal mucosa of European seabass (Dicentrarchus labrax) fed low fish meal diets

description: Diet formulation and proximal composition. FM5, 5% fish meal diet; FM20, 20% fish meal diet; TH, tilapia hydrolysate diet; SH, shrimp hydrolysate diet; MH, mixed hydrolysate diet. (XLSX 10 kb)
DOI: 10.6084/m9.figshare.6350480.v1
title: Additional file 1: of Dietary aquaculture by-product hydrolysates: impact on the transcriptomic response of the intestinal mucosa of European seabass (Dicentrarchus labrax) fed low fish meal diets

description: Diet formulation and proximal composition. FM5, 5% fish meal diet; FM20, 20% fish meal diet; TH, tilapia hydrolysate diet; SH, shrimp hydrolysate diet; MH, mixed hydrolysate diet. (XLSX 10 kb)
DOI: 10.6084/m9.figshare.6350471
title: Additional file 9: of Gut microbes contribute to variation in solid organ transplant outcomes in mice

description: Fecal microbiota ASVs in male skin transplant donors. Table providing percent relative abundance of all ASVs and their assigned taxonomy in all male skin transplant donors used in this study. Some ASVs listed were not detected in these samples but were detected in other samples from this study. (XLSX 33Â kb)
DOI: 10.6084/m9.figshare.6350471.v1
title: Additional file 9: of Gut microbes contribute to variation in solid organ transplant outcomes in mice

description: Fecal microbiota ASVs in male skin transplant donors. Table providing percent relative abundance of all ASVs and their assigned taxonomy in all male skin transplant donors used in this study. Some ASVs listed were not detected in these samples but were detected in other samples from this study. (XLSX 33Â kb)
DOI: 10.6084/m9.figshare.6350462
title: Additional file 8: of Gut microbes contribute to variation in solid organ transplant outcomes in mice

description: Fecal microbiota ASVs in outlier Tac cohort where Jax FMT did not improve graft survival. Table providing percent relative abundance of all ASVs and their assigned taxonomy and results of statistical analysis in Tac mice following Jax or Tac FMT in a cohort where Jax FMT did not prolong graft survival. Some ASVs listed were not detected in these samples but were detected in other samples from this study. (XLSX 27Â kb)
DOI: 10.6084/m9.figshare.6350462.v1
title: Additional file 8: of Gut microbes contribute to variation in solid organ transplant outcomes in mice

description: Fecal microbiota ASVs in outlier Tac cohort where Jax FMT did not improve graft survival. Table providing percent relative abundance of all ASVs and their assigned taxonomy and results of statistical analysis in Tac mice following Jax or Tac FMT in a cohort where Jax FMT did not prolong graft survival. Some ASVs listed were not detected in these samples but were detected in other samples from this study. (XLSX 27Â kb)
DOI: 10.6084/m9.figshare.6350456
title: Additional file 2: of Experiences with the implementation of Individual Placement and Support for people with severe mental illness: a qualitative study among stakeholders

description: Experiences with the implementation of Individual Placement and Support for people with severe mental illness: a qualitative study among stakeholders. Table S2. Thematic overview of perceived facilitators and barriers. (XLSX 27Â kb)
DOI: 10.6084/m9.figshare.6350456.v1
title: Additional file 2: of Experiences with the implementation of Individual Placement and Support for people with severe mental illness: a qualitative study among stakeholders

description: Experiences with the implementation of Individual Placement and Support for people with severe mental illness: a qualitative study among stakeholders. Table S2. Thematic overview of perceived facilitators and barriers. (XLSX 27Â kb)
DOI: 10.6084/m9.figshare.6350453
title: Additional file 7: of Gut microbes contribute to variation in solid organ transplant outcomes in mice

description: Fecal microbiota ASVs in Jax and Tac mice before and after FMT. Tables providing percent relative abundance of all ASVs and their assigned taxonomy in Jax and Tac fecal samples before FMT and after self-FMT or cross-vendor-FMT with results of statistical analysis. Some ASVs listed were not detected in these samples but were detected in other samples from this study. (XLSX 79Â kb)
DOI: 10.6084/m9.figshare.6350453.v1
title: Additional file 7: of Gut microbes contribute to variation in solid organ transplant outcomes in mice

description: Fecal microbiota ASVs in Jax and Tac mice before and after FMT. Tables providing percent relative abundance of all ASVs and their assigned taxonomy in Jax and Tac fecal samples before FMT and after self-FMT or cross-vendor-FMT with results of statistical analysis. Some ASVs listed were not detected in these samples but were detected in other samples from this study. (XLSX 79Â kb)
DOI: 10.6084/m9.figshare.6350444
title: Additional file 6: of Gut microbes contribute to variation in solid organ transplant outcomes in mice

description: Fecal microbiota ASVs in Jax and Tac mice before and after cohousing. Tables providing percent relative abundance of all ASVs and their assigned taxonomy in Jax and Tac fecal samples before and after cohousing with results of statistical analysis. Some ASVs listed were not detected in these samples but were detected in other samples from this study. (XLSX 100Â kb)
DOI: 10.6084/m9.figshare.6350444.v1
title: Additional file 6: of Gut microbes contribute to variation in solid organ transplant outcomes in mice

description: Fecal microbiota ASVs in Jax and Tac mice before and after cohousing. Tables providing percent relative abundance of all ASVs and their assigned taxonomy in Jax and Tac fecal samples before and after cohousing with results of statistical analysis. Some ASVs listed were not detected in these samples but were detected in other samples from this study. (XLSX 100Â kb)
DOI: 10.6084/m9.figshare.6350432
title: Additional file 5: of Gut microbes contribute to variation in solid organ transplant outcomes in mice

description: Transfer efficiency of ASVs following cohousing or FMT. Tables identifying ASVs detected in the majority of mice from either Jax or Tac prior to cohousing or FMT and which of these ASVs were gained or lost by cohousing or FMT. (XLSX 233Â kb)
DOI: 10.6084/m9.figshare.6350432.v1
title: Additional file 5: of Gut microbes contribute to variation in solid organ transplant outcomes in mice

description: Transfer efficiency of ASVs following cohousing or FMT. Tables identifying ASVs detected in the majority of mice from either Jax or Tac prior to cohousing or FMT and which of these ASVs were gained or lost by cohousing or FMT. (XLSX 233Â kb)
DOI: 10.6084/m9.figshare.6350417
title: Additional file 3: of The contribution of culturomics to the repertoire of isolated human bacterial and archaeal species

description: This table represents all the bacterial species isolated at least once from the human being, classified according to its phylum and combining the present work and the previous species reported by Hugon et al., in 2015. (XLSX 73 kb)
DOI: 10.6084/m9.figshare.6350417.v1
title: Additional file 3: of The contribution of culturomics to the repertoire of isolated human bacterial and archaeal species

description: This table represents all the bacterial species isolated at least once from the human being, classified according to its phylum and combining the present work and the previous species reported by Hugon et al., in 2015. (XLSX 73 kb)
DOI: 10.6084/m9.figshare.6350408
title: Additional file 3: of Gut microbes contribute to variation in solid organ transplant outcomes in mice

description: Fecal microbiota ASVs in Jax and Tac mice at baseline. Table providing percent relative abundance of all ASVs and their assigned taxonomy in Jax and Tac fecal samples at baseline and the 12 most abundant ASVs when averaged across all samples. Some ASVs listed were not detected in these samples but were detected in other samples from this study. (XLSX 52Â kb)
DOI: 10.6084/m9.figshare.6350408.v1
title: Additional file 3: of Gut microbes contribute to variation in solid organ transplant outcomes in mice

description: Fecal microbiota ASVs in Jax and Tac mice at baseline. Table providing percent relative abundance of all ASVs and their assigned taxonomy in Jax and Tac fecal samples at baseline and the 12 most abundant ASVs when averaged across all samples. Some ASVs listed were not detected in these samples but were detected in other samples from this study. (XLSX 52Â kb)
DOI: 10.6084/m9.figshare.6350402
title: Additional file 2: of The contribution of culturomics to the repertoire of isolated human bacterial and archaeal species

description: This table represents, in sheet 1, the taxonomic classification of the bacterial species according to NCBI taxonomy ( https://www.ncbi.nlm.nih.gov/Taxonomy/taxonomyhome.html/ ) and, in sheet 2, all the species classification according to their phylum and that have not been added yet in NCBI taxonomy database. (XLSX 514 kb)
DOI: 10.6084/m9.figshare.6350402.v1
title: Additional file 2: of The contribution of culturomics to the repertoire of isolated human bacterial and archaeal species

description: This table represents, in sheet 1, the taxonomic classification of the bacterial species according to NCBI taxonomy ( https://www.ncbi.nlm.nih.gov/Taxonomy/taxonomyhome.html/ ) and, in sheet 2, all the species classification according to their phylum and that have not been added yet in NCBI taxonomy database. (XLSX 514 kb)
DOI: 10.6084/m9.figshare.6350393
title: Additional file 2: of Gut microbes contribute to variation in solid organ transplant outcomes in mice

description: Phylum-level fecal microbiota composition in Jax and Tac mice at baseline. Table providing percent relative abundance of all detected phyla in Jax and Tac fecal samples at baseline. (XLSX 10Â kb)
DOI: 10.6084/m9.figshare.6350393.v1
title: Additional file 2: of Gut microbes contribute to variation in solid organ transplant outcomes in mice

description: Phylum-level fecal microbiota composition in Jax and Tac mice at baseline. Table providing percent relative abundance of all detected phyla in Jax and Tac fecal samples at baseline. (XLSX 10Â kb)
DOI: 10.6084/m9.figshare.6350390
title: Additional file 1: of The contribution of culturomics to the repertoire of isolated human bacterial and archaeal species

description: General characteristics of the reported species in this repertoire along with its classification based on oxygen tolerance (0 being able to tolerate oxygen and 1 strictly anaerobic), risk group, potential pathogenicity, and the PMID of the article. A: New species isolated by culturomics approach but not in the gut. B: Species isolated without culturomics approach and not isolated in the gut. C: New species isolated not using culturomics approach. D: Species isolated by routine culture in our laboratory. E: Species isolated in the human gut by culturomics. F: New species isolated in the human gut by culturomics. G: Species isolated in the human gut and without using culturomics. (XLSX 40 kb)