cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.8034887.v1
title: Supplementary Material for: Systemic Treatment Options for Carcinoid Syndrome: A Systematic Review

description: <b><i>Background:</i></b> Carcinoid syndrome symptoms significantly reduce quality of life in patients with neuroendocrine tumors. Evidence supporting the use of somatostatin analogues in carcinoid syndrome symptom control dates back 30 years. The introduction of new treatment options for carcinoid syndrome, such as telotristat ethyl in 2017, highlights the need for a review of high-level evidence of new and established systemic treatments. <b><i>Objective:</i></b> To examine the efficacy and safety of systemic treatment options for patients with carcinoid syndrome. <b><i>Method:</i></b> A systematic review of English language articles was conducted using PubMed, EMBASE, and the Cochrane Controlled Trials Register using the search terms carcinoid syndrome, clinical trial, clinical study, and prospective study. Additional studies were identified by searching abstracts from oncology or neuroendocrine tumor congresses during the previous year. Prospective, interventional, phase II or III clinical trials or pivotal trials leading to drug approval were included. Studies were required to have &gt;85% of patients with carcinoid syndrome; secondary publications were excluded. <b><i>Results:</i></b> The search identified 233 unique records, of which 12 trials met the criteria for inclusion. Interventions assessed in these trials included short-acting and long-acting octreotide, lanreotide prolonged-release and autogel/depot, short-acting and long-acting pasireotide, telotristat ethyl, everolimus, and peptide receptor radionuclide therapy. Somatostatin analogues provided substantial symptom relief for patients with carcinoid syndrome. For refractory symptoms, an increased dose of somatostatin analogue or addition of telotristat ethyl were valuable options. Interventions were generally well tolerated, with few serious treatment-related adverse events. <b><i>Conclusions:</i></b> By critically evaluating high-level evidence in a rigorous manner, this review highlights the general lack of consensus regarding what defines symptom control in studies of carcinoid syndrome and the need for standardized treatment guidelines for this disease. More prospective trials of treatments for carcinoid syndrome are warranted to assist oncologists with optimizing treatment selection and sequencing in this patient population.
DOI: 10.6084/m9.figshare.8034761
title: Hf isotopic results of detrital zircons from all samples. Detrital zircon record from major rivers of Luzon Island: Implications for Cenozoic continental growth in Southeast Asia

description: Supplementary Table 2: Hf isotopic results of detrital zircons from all samples.
DOI: 10.6084/m9.figshare.8034764
title: Supplementary Material for: Different Psychosocial Factors Are Associated with Seasonal and Perennial Allergies in Adults: Cross-Sectional Results of the KORA FF4 Study

description: <b><i>Background:</i></b> Psychosocial factors are supposed to play a central role in the development of allergic diseases. Associations with seasonal and perennial forms of allergies have not been investigated, yet. <b><i>Objectives:</i></b> The aim of the study was to investigate the associations of psychosocial factors (social status, depression, generalized anxiety, psychosocial stress, Type-D personality) with seasonal, perennial, and other forms of allergies in adults. <b><i>Method:</i></b> The analysis of self-reported data of the KORA FF4 study was performed with SAS 9.4. The sample consisted of 1,782 study participants in the study region of Augsburg (39–88 years, 61 years, 51.1% female). Descriptive bivariate statistics and multinomial logistic regression models were performed. Age, sex, family predisposition, and smoking status were considered possible confounders. Moreover, several sensitivity analyses were carried out to check whether missing values distorted the results. <b><i>Results:</i></b> A positive association between generalized anxiety and seasonal allergies was found in the multivariate model. Depression was positively, and anxiety negatively, associated with perennial allergies. No association between the analyzed psychosocial factors and other forms of allergies could be found. <b><i>Conclusion:</i></b> The results support the relevance of psychosocial factors in association with allergies. Looking at the psychosocial factors, a separate consideration of seasonal and perennial allergies seems reasonable. Further longitudinal studies should investigate the direction of the associations, the underlying mechanisms, and other psychosocial factors, such as coping mechanisms, in confirmed allergies.
DOI: 10.6084/m9.figshare.8034758
title: U–Pb ages of detrital zircons from all samples. Detrital zircon record from major rivers of Luzon Island: Implications for Cenozoic continental growth in Southeast Asia

description: Supplementary Table 1: U–Pb ages of detrital zircons from all samples.
DOI: 10.6084/m9.figshare.8034758.v1
title: U–Pb ages of detrital zircons from all samples. Detrital zircon record from major rivers of Luzon Island: Implications for Cenozoic continental growth in Southeast Asia

description: Supplementary Table 1: U–Pb ages of detrital zircons from all samples.
DOI: 10.6084/m9.figshare.8034737
title: Investigating specificity of the anti-hypertensive inhibitor WNK463 against With-No-Lysine kinase family isoforms via multiscale simulations

description: The With-No-Lysine (WNK) kinase family plays a significant role in regulating cation-chloride cotransporters, blood pressure and body fluid homeostasis. Mutations in the gene of WNK family, especially in WNK1 and WNK4 are responsible for pseudohypoaldosteronism type II (PHAII), characterized by hypertension. The selective inhibition of WNK1 over other isoforms has created an immense challenge in the design of an ATP competitive inhibitor due to their high conservatism. In this work, we have compared the selectivity of the inhibitor WNK463, which was designed for WNK1 with other WNK family isoforms by comprehensive molecular modeling, docking and molecular dynamics simulations in conjunction with the Molecular Mechanics Poisson-Boltzmann Surface Area method. Our calculations show that the affinity of the inhibitor decreases in the order WNK2 &gt; WNK1 &gt; WNK3 &gt; WNK4, in agreement with the experiment. Our study reveals that the inhibitor is most selective to WNK2 due to decreased polar solvation and configurational entropy compared to other isoforms. Furthermore, our analyses indicated that the nonpolar contribution from the hydrophobic residues and hydrogen bonds in the hinge region gatekeeper residue Met<sup>304</sup> of WNK1 and its equivalent residue from other kinases played a critical role in stabilizing the inhibitor against WNK kinases. Residues Lys<sup>233</sup>, Met<sup>304</sup>, Phe<sup>356</sup> and Leu<sup>369</sup> of WNK1 were the essential residue differences compared to other isoforms that led to specific interactions thereby forming the basis of molecular binding pattern of binding interactions. Overall, we have identified conserved WNK-inhibitor interactions and elucidated isoform-specific interactions that could be exploited in the design of more potent and selective WNK inhibitors. Communicated by Ramaswamy H. Sarma
DOI: 10.6084/m9.figshare.8034704
title: Supplementary Material for: Assessing Inspiratory Muscle Strength for Early Detection of Respiratory Failure in Motor Neuron Disease: Should We Use MIP, SNIP, or Both?

description: <b><i>Background:</i></b> Motor neuron disease (MND) invariably impacts on inspiratory muscle strength leading to respiratory failure. Regular assessment of sniff nasal inspiratory pressure (SNIP) and/or maximal mouth inspiratory pressure (MIP) contributes to early detection of a requirement for ventilatory support. <b><i>Objectives:</i></b> The aim of this study was to compare the feasibility, agreement, and performance of both tests in MND. <b><i>Methods:</i></b> Patients with MND followed by a multidisciplinary consultation were prospectively included. Pulmonary follow-up included forced expiratory volumes, vital capacity (VC) seated and supine, MIP, SNIP, pulse oximetry, and daytime arterial blood gases. <b><i>Results:</i></b> A total of 61 patients were included. SNIP and MIP could not be performed in 14 (21%) subjects; 74% of the subjects showed a decrease in MIP or SNIP at inclusion versus 31% for VC. Correlation between MIP and SNIP (Pearson’s rho: 0.68, <i>p</i> &lt; 0.001) was moderate, with a non-significant bias in favor of SNIP (3.6 cm H<sub>2</sub>O) and wide limits of agreement (–34 to 41 cm H<sub>2</sub>O). Results were similar in “bulbar” versus “non-bulbar” patients. At different proposed cut-off values for identifying patients at risk of respiratory failure, the agreement between MIP and SNIP (64–79%) and kappa values (0.29–0.53) was moderate. <b><i>Conclusions:</i></b> MIP and SNIP were equally feasible. There was no significant bias in favor of either test, but a considerable disparity in results between tests, suggesting that use of both tests is warranted to screen for early detection of patients at risk of respiratory failure and avoid over diagnoses. SNIP, MIP, and VC all follow a relatively linear downhill course with a steeper slope for “bulbar” versus “non-bulbar” patients.
DOI: 10.6084/m9.figshare.8034737.v1
title: Investigating specificity of the anti-hypertensive inhibitor WNK463 against With-No-Lysine kinase family isoforms via multiscale simulations

description: The With-No-Lysine (WNK) kinase family plays a significant role in regulating cation-chloride cotransporters, blood pressure and body fluid homeostasis. Mutations in the gene of WNK family, especially in WNK1 and WNK4 are responsible for pseudohypoaldosteronism type II (PHAII), characterized by hypertension. The selective inhibition of WNK1 over other isoforms has created an immense challenge in the design of an ATP competitive inhibitor due to their high conservatism. In this work, we have compared the selectivity of the inhibitor WNK463, which was designed for WNK1 with other WNK family isoforms by comprehensive molecular modeling, docking and molecular dynamics simulations in conjunction with the Molecular Mechanics Poisson-Boltzmann Surface Area method. Our calculations show that the affinity of the inhibitor decreases in the order WNK2 &gt; WNK1 &gt; WNK3 &gt; WNK4, in agreement with the experiment. Our study reveals that the inhibitor is most selective to WNK2 due to decreased polar solvation and configurational entropy compared to other isoforms. Furthermore, our analyses indicated that the nonpolar contribution from the hydrophobic residues and hydrogen bonds in the hinge region gatekeeper residue Met<sup>304</sup> of WNK1 and its equivalent residue from other kinases played a critical role in stabilizing the inhibitor against WNK kinases. Residues Lys<sup>233</sup>, Met<sup>304</sup>, Phe<sup>356</sup> and Leu<sup>369</sup> of WNK1 were the essential residue differences compared to other isoforms that led to specific interactions thereby forming the basis of molecular binding pattern of binding interactions. Overall, we have identified conserved WNK-inhibitor interactions and elucidated isoform-specific interactions that could be exploited in the design of more potent and selective WNK inhibitors. Communicated by Ramaswamy H. Sarma
DOI: 10.6084/m9.figshare.8034704.v1
title: Supplementary Material for: Assessing Inspiratory Muscle Strength for Early Detection of Respiratory Failure in Motor Neuron Disease: Should We Use MIP, SNIP, or Both?

description: <b><i>Background:</i></b> Motor neuron disease (MND) invariably impacts on inspiratory muscle strength leading to respiratory failure. Regular assessment of sniff nasal inspiratory pressure (SNIP) and/or maximal mouth inspiratory pressure (MIP) contributes to early detection of a requirement for ventilatory support. <b><i>Objectives:</i></b> The aim of this study was to compare the feasibility, agreement, and performance of both tests in MND. <b><i>Methods:</i></b> Patients with MND followed by a multidisciplinary consultation were prospectively included. Pulmonary follow-up included forced expiratory volumes, vital capacity (VC) seated and supine, MIP, SNIP, pulse oximetry, and daytime arterial blood gases. <b><i>Results:</i></b> A total of 61 patients were included. SNIP and MIP could not be performed in 14 (21%) subjects; 74% of the subjects showed a decrease in MIP or SNIP at inclusion versus 31% for VC. Correlation between MIP and SNIP (Pearson’s rho: 0.68, <i>p</i> &lt; 0.001) was moderate, with a non-significant bias in favor of SNIP (3.6 cm H<sub>2</sub>O) and wide limits of agreement (–34 to 41 cm H<sub>2</sub>O). Results were similar in “bulbar” versus “non-bulbar” patients. At different proposed cut-off values for identifying patients at risk of respiratory failure, the agreement between MIP and SNIP (64–79%) and kappa values (0.29–0.53) was moderate. <b><i>Conclusions:</i></b> MIP and SNIP were equally feasible. There was no significant bias in favor of either test, but a considerable disparity in results between tests, suggesting that use of both tests is warranted to screen for early detection of patients at risk of respiratory failure and avoid over diagnoses. SNIP, MIP, and VC all follow a relatively linear downhill course with a steeper slope for “bulbar” versus “non-bulbar” patients.
DOI: 10.6084/m9.figshare.8034680
title: Using Fractionation and Diffusion Ordered Spectroscopy to Study Lignin Molecular Weight - Chemistry Open - Raw underpinning data.

description: Raw NMR and GPC data supporting full paper - J. R. D. Montgomery, P. Bazley, T. Lebl, N. J. Westwood, Using Fractionation and Diffusion Ordered Spectroscopy to Study Lignin Molecular Weight, Chemistry Open, 2019.<b>DOI:</b> 10.1002/open.201900129<br><br>
DOI: 10.6084/m9.figshare.8034662
title: Supplementary Material for: No Difference in Prevalence of Transmitted Drug Resistance between Injection Drug Users and Non-Injection Drug Users: A Cross-Sectional Study among Antiretroviral Treatment-Naïve HIV Patients

description: <b><i>Objectives:</i></b> The epidemiological evidence is inconsistent about whether HIV-positive injection drug users (IDUs) are at higher risk of developing antiretroviral resistance than any other HIV-positive populations. This study aims to investigate and compare transmitted drug resistance (TDR) between IDUs and non-IDUs in Lingshan County, an HIV-hit region in Guangxi, China, where IDU and heterosexual transmission were the two dominant transmission routes and roughly equally contributed to the local HIV transmission. <b><i>Methods:</i></b> A cross-sectional study was conducted among newly diagnosed and antiretroviral-treatment (ART)-naïve HIV-1 patients from Lingshan County. The <i>pol</i> gene of HIV-1 from the individuals was sequenced followed by genotyping and TDR analysis. <b><i>Results:</i></b> Two dominant transmission routes, heterosexual contact and IDU, accounted for 49.2 and 45.9% of 183 HIV-1 infection cases, respectively. Three genotypes, including CRF08_BC (70.6%), CRF01_AE (24.4%), and CRF07_BC (5.0%), and three unique recombinant forms (1.6%), were identified. There was a significant difference in genotype distribution among the different transmission routes (<i>F</i> = 21.814, <i>p</i> &lt; 0.001). The overall TDR prevalence was 5.5%. There were no significant differences in TDR prevalence among the different transmission routes (<i>F</i> = 1.420, <i>p</i> = 0.439). <b><i>Conclusions:</i></b> Injection drug use has little impact on TDR prevalence compared with other routes of transmission.
DOI: 10.6084/m9.figshare.8034668
title: Making errors at work due to sleepiness or sleep problems is not confined to non-standard work hours: results of the 2016 Sleep Health Foundation national survey

description: Almost one-third of Australians report having made errors at work that are related to sleep issues. While there is significant literature investigating the role of sleep in workplace health and safety in shiftworking and nightwork operations, long working hours, work-family conflict, and commute times getting longer also impact day workers’ sleep behaviors and opportunities. The aim of this study was to examine the relationship between sleep duration and disorders, sleep health and hygiene factors, work-related factors and errors at work in Australian workers. From a sample of 1011 Australian adults, age-adjusted binary logistic regression analyses were conducted in 512 workers who provided responses to the question “Thinking about the past three months, how many days did you make errors at work because you were too sleepy or you had a sleep problem?” A number of sleep behaviors and poor sleep hygiene factors were linked with work errors related to sleepiness or sleep problems, with age-adjusted odds of errors (confidence intervals) up to 11.6 times higher (5.4–25.1, <i>p</i> &lt; 0.001) in those that snored, 7.7 (4.6–12.9) times higher in those reporting more than three sleep issues (<i>p</i> &lt; 0.001), 7.0 times higher (3.4–14.8) in short (≤5 hours/night) sleepers (<i>p</i> &lt; 0.021), 6.1 times higher (2.9–12.7) in those staying up later than planned most nights of the week (<i>p</i>&lt; 0.001) and 2.4 times higher (1.6–3.7) in those drinking alcohol ≥3 nights/week before bed (<i>p</i> &lt; 0.001). More than 40% of participants working non-standard hours reported making errors at work, and they were more likely to be young (compared to the main sample of workers) and more likely to engage in work activities in the hour before bed. Sleep factors (other than clinical sleep disorders) were associated with an increased likelihood of sleep-related work errors. Both day workers and those working non-standard hours engage in work, sleep and health behaviors that do not support good sleep health, which may be impacting safety and productivity in the workplace through increased sleepiness-related errors.
DOI: 10.6084/m9.figshare.8034680.v1
title: Using Fractionation and Diffusion Ordered Spectroscopy to Study Lignin Molecular Weight - Chemistry Open - Raw underpinning data.

description: Raw NMR and GPC data supporting full paper - J. R. D. Montgomery, P. Bazley, T. Lebl, N. J. Westwood, Using Fractionation and Diffusion Ordered Spectroscopy to Study Lignin Molecular Weight, Chemistry Open, 2019.<b>DOI:</b> 10.1002/open.201900129<br><br>
DOI: 10.6084/m9.figshare.8034668.v1
title: Making errors at work due to sleepiness or sleep problems is not confined to non-standard work hours: results of the 2016 Sleep Health Foundation national survey

description: Almost one-third of Australians report having made errors at work that are related to sleep issues. While there is significant literature investigating the role of sleep in workplace health and safety in shiftworking and nightwork operations, long working hours, work-family conflict, and commute times getting longer also impact day workers’ sleep behaviors and opportunities. The aim of this study was to examine the relationship between sleep duration and disorders, sleep health and hygiene factors, work-related factors and errors at work in Australian workers. From a sample of 1011 Australian adults, age-adjusted binary logistic regression analyses were conducted in 512 workers who provided responses to the question “Thinking about the past three months, how many days did you make errors at work because you were too sleepy or you had a sleep problem?” A number of sleep behaviors and poor sleep hygiene factors were linked with work errors related to sleepiness or sleep problems, with age-adjusted odds of errors (confidence intervals) up to 11.6 times higher (5.4–25.1, <i>p</i> &lt; 0.001) in those that snored, 7.7 (4.6–12.9) times higher in those reporting more than three sleep issues (<i>p</i> &lt; 0.001), 7.0 times higher (3.4–14.8) in short (≤5 hours/night) sleepers (<i>p</i> &lt; 0.021), 6.1 times higher (2.9–12.7) in those staying up later than planned most nights of the week (<i>p</i>&lt; 0.001) and 2.4 times higher (1.6–3.7) in those drinking alcohol ≥3 nights/week before bed (<i>p</i> &lt; 0.001). More than 40% of participants working non-standard hours reported making errors at work, and they were more likely to be young (compared to the main sample of workers) and more likely to engage in work activities in the hour before bed. Sleep factors (other than clinical sleep disorders) were associated with an increased likelihood of sleep-related work errors. Both day workers and those working non-standard hours engage in work, sleep and health behaviors that do not support good sleep health, which may be impacting safety and productivity in the workplace through increased sleepiness-related errors.
DOI: 10.6084/m9.figshare.8034596
title: Como regalarle un poco de placer a ellas.docx

description: Omegle el nuevo concepto de contenido para adultos
DOI: 10.6084/m9.figshare.8034596.v1
title: Como regalarle un poco de placer a ellas.docx

description: Omegle el nuevo concepto de contenido para adultos
DOI: 10.6084/m9.figshare.8034584.v1
title: EU referendum data 1972-2018

description: This is the primary data set to a wide-range study of European referendums from 1972 to 2018. Data to 28 EU member states are provided and include the turnover and YES/in-favor results. Moreover, the referendums are classified according to four distinct types (sovereignty, EU matters, constitutional and policy issues). The novel concept of sphere distribution is hereby introduced and includes five elements (private: 1; family: 2; society: 3; state: 4; institutional: 5). All data are backed by official sources when possible. This data set is the prelude to a relevant journal paper to be announced in late 2019.
DOI: 10.6084/m9.figshare.8034584.v2
title: EU referendum data 1972-2018

description: This is the primary data set to a wide-range study of European referendums from 1972 to 2018. Data to 28 EU member states are provided and include the turnover and YES/in-favor results. Moreover, the referendums are classified according to four distinct types (sovereignty, EU matters, constitutional and policy issues). The novel concept of sphere distribution is hereby introduced and includes five elements (private: 1; family: 2; society: 3; state: 4; institutional: 5). All data are backed by official sources when possible. This data set is the prelude to a relevant journal paper to be announced in late 2019.
DOI: 10.11583/dtu.8034188
title: Leading sustainability indicators for circular economy

description: This database is a comprehensive collection of leading sustainability-related indicators for manufacturing companies. The indicators are collected through a systematic literature review with following information registered: name, detailed description, formula, unit of measurement, and purpose of measurement. The leading indicators in the database are classified according to environmental, economic and social dimensions of sustainability, for a range of business processes and various circular economy strategies. This classification allows the configuration of different combinations of circular solutions to be exploited in various business processes, thus displaying a suitable set of sustainability performance indicators to be measured early in the decision-making stage. The database of performance indicators is a first building block of a foundation for the development of a sustainability screening framework, which will also comprise a procedure for a systematic indicator selection and guidelines for decision-making for sustainability in a circular economy context.