cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.19899585
title: Artichoke extracts with potential application in chemoprevention and inflammatory processes

description: Abstract The aim of this work is to study three cultivars of artichoke (Cynara cardunculus var. scolymus): Gauchito, Guri and Oro Verde in terms of their in vitro chemoprevention and anti-inflammatory properties. These cultivars show good productive performance. The phenolic composition of their fresh leaves and edible bracts was analyzed by high performance liquid chromatography and high resolution mass spectrometry (HPLC-HRMS), showing mainly caffeoylquinic acids and flavonoids. Caffeoylquinic acids were quantified and the highest content was found in Gauchito cultivar. In this cultivar, the content of dicaffeoylquinic acids in fresh bracts was six times higher than that in fresh leaves (10064.5 ± 378.3 mg/kg versus 1451.0 ± 209.3 mg/kg respectively). Luteolin flavonoids were detected in leaves. The extracts from fresh bracts and leaves were assessed in their in vitro bioactivity against human neuroblastoma cells (SH-SY5Y). Inhibition of SH-SY5Y cells proliferation by Gauchito and Guri leaf extracts (8 µg/mL) was higher than 50 %. The leaf extracts of the same cultivars showed an inhibitory effect on human interferon IFN-I, decreasing its activity 50% at 40 µg/mL. Interestingly, the bract extracts did not show in vitro bioactivity at these concentrations, nor did the pure compounds chlorogenic acid, cynarin, apigenin and luteolin (at 2 µg/mL). These results suggest that Gauchito and Guri leaf extracts have potential for human neuroblastoma chemoprevention and treatment of inflammatory processes.
DOI: 10.6084/m9.figshare.19899585.v1
title: Artichoke extracts with potential application in chemoprevention and inflammatory processes

description: Abstract The aim of this work is to study three cultivars of artichoke (Cynara cardunculus var. scolymus): Gauchito, Guri and Oro Verde in terms of their in vitro chemoprevention and anti-inflammatory properties. These cultivars show good productive performance. The phenolic composition of their fresh leaves and edible bracts was analyzed by high performance liquid chromatography and high resolution mass spectrometry (HPLC-HRMS), showing mainly caffeoylquinic acids and flavonoids. Caffeoylquinic acids were quantified and the highest content was found in Gauchito cultivar. In this cultivar, the content of dicaffeoylquinic acids in fresh bracts was six times higher than that in fresh leaves (10064.5 ± 378.3 mg/kg versus 1451.0 ± 209.3 mg/kg respectively). Luteolin flavonoids were detected in leaves. The extracts from fresh bracts and leaves were assessed in their in vitro bioactivity against human neuroblastoma cells (SH-SY5Y). Inhibition of SH-SY5Y cells proliferation by Gauchito and Guri leaf extracts (8 µg/mL) was higher than 50 %. The leaf extracts of the same cultivars showed an inhibitory effect on human interferon IFN-I, decreasing its activity 50% at 40 µg/mL. Interestingly, the bract extracts did not show in vitro bioactivity at these concentrations, nor did the pure compounds chlorogenic acid, cynarin, apigenin and luteolin (at 2 µg/mL). These results suggest that Gauchito and Guri leaf extracts have potential for human neuroblastoma chemoprevention and treatment of inflammatory processes.
DOI: 10.6084/m9.figshare.19899594
title: Therapeutic role of memantine for the prevention of cognitive decline in cancer patients with brain metastasis receiving whole-brain radiotherapy: a narrative review

description: ABSTRACT. Brain metastases are the most common central nervous system tumors. The mainstay treatment for this tumor in low to middle income countries is whole brain radiation therapy. Irreversible cognitive decline is associated with the use of whole brain radiotherapy. Several pharmacologic and nonpharmacologic options have been employed in studies focusing on the prevention of cognitive decline following whole-brain radiation therapy. Memantine use has been shown to provide some benefit in reducing the rate of decline in cognitive function and time to cognitive failure. The objective of this review article is to provide a summary on available primary literature on the therapeutic role of memantine for the prevention of cognitive decline in cancer patients with brain metastasis receiving whole brain radiotherapy.
DOI: 10.6084/m9.figshare.19899594.v1
title: Therapeutic role of memantine for the prevention of cognitive decline in cancer patients with brain metastasis receiving whole-brain radiotherapy: a narrative review

description: ABSTRACT. Brain metastases are the most common central nervous system tumors. The mainstay treatment for this tumor in low to middle income countries is whole brain radiation therapy. Irreversible cognitive decline is associated with the use of whole brain radiotherapy. Several pharmacologic and nonpharmacologic options have been employed in studies focusing on the prevention of cognitive decline following whole-brain radiation therapy. Memantine use has been shown to provide some benefit in reducing the rate of decline in cognitive function and time to cognitive failure. The objective of this review article is to provide a summary on available primary literature on the therapeutic role of memantine for the prevention of cognitive decline in cancer patients with brain metastasis receiving whole brain radiotherapy.
DOI: 10.6084/m9.figshare.19899596
title: Work as an Educational Principle in Mathematics Activities in Technical and Vocational Education and Training

description: Abstract This paper seeks to reflect on how Brazilian Mathematics teachers consider work as an educational principle in Technical and Vocational Education and Training (TVET) at Secondary School Level. To this aim, our empirical data consists of reports of experiences with students on TVET courses, published in the proceedings of the National Meetings on Mathematics Education, from 2010 to 2019. Our theoretical framework includes a Marxist perspective and Brazilian research on Professional and Technological Education. The study’s methodological design is based on a protocol for the inclusion and exclusion of paper in the corpus of analysis, considering the occurrences of the terms “technical”, “technician” or “professional” in the text body. The analysis followed an inductive perspective, inspired by Lincoln and Guba (1985). Based on the textual units found, we built up categories from which we discuss the idea of work as an educative principle, highlighting three possibilities of actual effects on teaching. Beyond creating a typology, we aim to shed light on different teaching strategies resorted to implement the curricular guidelines of TVET in mathematical activities. With this, we hope to stress the potentialities and limitations of each approach, to encourage teachers to transform their educational practice and, thus, consolidate the integral education of their students.
DOI: 10.6084/m9.figshare.19899596.v1
title: Work as an Educational Principle in Mathematics Activities in Technical and Vocational Education and Training

description: Abstract This paper seeks to reflect on how Brazilian Mathematics teachers consider work as an educational principle in Technical and Vocational Education and Training (TVET) at Secondary School Level. To this aim, our empirical data consists of reports of experiences with students on TVET courses, published in the proceedings of the National Meetings on Mathematics Education, from 2010 to 2019. Our theoretical framework includes a Marxist perspective and Brazilian research on Professional and Technological Education. The study’s methodological design is based on a protocol for the inclusion and exclusion of paper in the corpus of analysis, considering the occurrences of the terms “technical”, “technician” or “professional” in the text body. The analysis followed an inductive perspective, inspired by Lincoln and Guba (1985). Based on the textual units found, we built up categories from which we discuss the idea of work as an educative principle, highlighting three possibilities of actual effects on teaching. Beyond creating a typology, we aim to shed light on different teaching strategies resorted to implement the curricular guidelines of TVET in mathematical activities. With this, we hope to stress the potentialities and limitations of each approach, to encourage teachers to transform their educational practice and, thus, consolidate the integral education of their students.
DOI: 10.6084/m9.figshare.19899609
title: Recommendations for the implementation of interoperability between SINAPI and NBR 15965 standards

description: Abstract Data interchangeability is a requirement of information digitalization. The digitization of information in Brazilian public works involves cost structure integration between the National System of Investigation of Costs and Indices of Civil Construction (SINAPI)) with the Building Information Model (BIM). The standard NBR 15965 - Construction Information Classification System has a different structure than SINAPI: this characteristic hinders interoperability. The aim of this research study is to make recommendations for the integration between the two systems. For this purpose, cost composition 92722 and its links with NBR 15965 codes were analysed. From the forty-five codes in NBR 15965, necessary for the characterization of the service, twelve are on the published tables “0P”, “1F” and “5I”; nineteen already could be in the published tables “0M”, “0P”, “1S” and “5I” and eleven codes could be considered for future tables (“2Q”, “2N”, “3R”, “3E” and “4A”). The recommendations made by this study are as follows: to associate properties (time, cost, material consumption) to the cost composition coefficients and include materials, materials’ properties and the choice criteria for the selection of construction services. The main contribution of this paper is the identification of gaps in SINAPI’s attributes and in NBR 15965 standards, configuring the first initiative for their integration.
DOI: 10.6084/m9.figshare.19899609.v1
title: Recommendations for the implementation of interoperability between SINAPI and NBR 15965 standards

description: Abstract Data interchangeability is a requirement of information digitalization. The digitization of information in Brazilian public works involves cost structure integration between the National System of Investigation of Costs and Indices of Civil Construction (SINAPI)) with the Building Information Model (BIM). The standard NBR 15965 - Construction Information Classification System has a different structure than SINAPI: this characteristic hinders interoperability. The aim of this research study is to make recommendations for the integration between the two systems. For this purpose, cost composition 92722 and its links with NBR 15965 codes were analysed. From the forty-five codes in NBR 15965, necessary for the characterization of the service, twelve are on the published tables “0P”, “1F” and “5I”; nineteen already could be in the published tables “0M”, “0P”, “1S” and “5I” and eleven codes could be considered for future tables (“2Q”, “2N”, “3R”, “3E” and “4A”). The recommendations made by this study are as follows: to associate properties (time, cost, material consumption) to the cost composition coefficients and include materials, materials’ properties and the choice criteria for the selection of construction services. The main contribution of this paper is the identification of gaps in SINAPI’s attributes and in NBR 15965 standards, configuring the first initiative for their integration.
DOI: 10.6084/m9.figshare.19899623
title: The chemical composition and antibacterial activity of a methanolic extract of Satureja khuzistanica

description: Abstract In the present study, the metabolite profiling of methanolic extract from aerial parts of Satureja khuzistanica Jamzad, as an endemic medicinal plant from Iran, was evaluated using HPLC-PDA-ESI. Then, the main compound from the extract was isolated and purified by using extensive chromatographic techniques. In addition, the structure of the isolated compounds was elucidated using 1D, 2D NMR, and MS spectrometry, upon which 22 compounds were identified. The antibacterial activity of diosmetin 7-rutinoside (6) and linarin (13) in combination with carvacrol as a major compound of the essential oil was tested against Pseudomonas aeruginosa and Staphylococcus aureus through disc diffusion and minimum inhibitory concentration methods. The results indicated that the linarin, when mixed with carvacrol as the main compounds in the essential oil of the plant, has a satisfactory activity against both Pseudomonas aeruginosa and Staphylococcus aureus with MIC values of 0.16 and 0.18 µg/mL, respectively. Further, the fractional inhibitory concentration (FIC) index indicated that this compound had synergism with carvacrol.
DOI: 10.6084/m9.figshare.19899623.v1
title: The chemical composition and antibacterial activity of a methanolic extract of Satureja khuzistanica

description: Abstract In the present study, the metabolite profiling of methanolic extract from aerial parts of Satureja khuzistanica Jamzad, as an endemic medicinal plant from Iran, was evaluated using HPLC-PDA-ESI. Then, the main compound from the extract was isolated and purified by using extensive chromatographic techniques. In addition, the structure of the isolated compounds was elucidated using 1D, 2D NMR, and MS spectrometry, upon which 22 compounds were identified. The antibacterial activity of diosmetin 7-rutinoside (6) and linarin (13) in combination with carvacrol as a major compound of the essential oil was tested against Pseudomonas aeruginosa and Staphylococcus aureus through disc diffusion and minimum inhibitory concentration methods. The results indicated that the linarin, when mixed with carvacrol as the main compounds in the essential oil of the plant, has a satisfactory activity against both Pseudomonas aeruginosa and Staphylococcus aureus with MIC values of 0.16 and 0.18 µg/mL, respectively. Further, the fractional inhibitory concentration (FIC) index indicated that this compound had synergism with carvacrol.
DOI: 10.5285/5f0ac285-cca3-4a0e-bcbc-d921734395ab
title: Fields and parameters related to the flow of ice in the Antarctic Ice Sheet recovered using inverse methods and satellite data

description: We can learn about the flow of ice in Antarctica by evaluating the key parameters that control the flow speed. These parameters include the basal drag coefficient and the ice viscosity. They can be estimated by adjusting their values so that model velocities at the upper surface agree with satellite observations. This dataset was produced using inverse methods to obtain the parameter values. In this approach a cost function that describes the mismatch between model and satellite data is minimised iteratively by making small adjustments to the parameters at each iteration to improve the fit. The result is better information about the flow field in the Antarctic ice sheet. Once the flow field is available it can be used as an initial state from which begin temporally evolving simulations using the model. A number of different examples are included to show how varying different parameters alters the temporally evolving simulations. The contributing datasets used to constrain the model are listed by Arthern et al (2015) and Arthern and Williams (2017). Multidecadal model simulations span up to 100 years of simulation time. This work was funded by NERC standard grant NE/L005212/1.
description: The processing of the data is described by Arthern et al. (2015) and Arthern and Williams (2017) (see references section). Inverse methods were used to find the basal drag and ice viscosity parameters that allow the model to agree best with satellite observations. Once the ice flow parameters have been obtained, the modelled ice flow within the ice sheet can be evaluated and used to start temporally evolving simulations for a variety of different parameter choices, as described by Arthern and Williams (2017).
description: Data processing and modelling was done using MATLAB (Version 8). The contributing datasets used to constrain the model are listed by Arthern et al (2015) and Arthern and Williams (2017). Multidecadal model simulations span up to 100 years of simulation time.
description: The algorithm used was evaluated on idealised test cases as described by Arthern and Gudmundsson (2010). Arthern et al (2015) shows maps of discrepancy between model velocity and satellite derived velocity, and histograms of the differences between model elevation changes and elevation changes derived using satellite altimetry. For the temporally evolving simulations two datasets are included; one as originally computed and one with accumulation rates corrected for a processing error.
DOI: 10.6084/m9.figshare.19899632
title: LITERACY AND PROFESSORS’ PRACTICES: AN ANALYSIS OF LITERATURE

description: ABSTRACT: This study aims to review Brazilian research on literacy practices for undergraduate professors. We reviewed SciELO and Portal de Periódicos CAPES. From 2013 to 2019, 20 articles were retrieved and fulfilled inclusion criteria. Studies’ main statements were interpreted using a dialogical analysis of the discourse method. Few studies directly addressed the association between literacy practices and undergraduate professional training in Brazilian higher education. Among these studies, there was a predominance of the procedural technical guidance method, which seeks to improve reading and writing practices in undergraduate courses, particularly for human sciences. The relevance of literacy while becoming a higher education professor in Brazil is discussed in light of previous international research. An interdisciplinary approach, guided by a discursive conception of language, may foster improvements for professors’ practices from different areas of knowledge.
DOI: 10.6084/m9.figshare.19899632.v1
title: LITERACY AND PROFESSORS’ PRACTICES: AN ANALYSIS OF LITERATURE

description: ABSTRACT: This study aims to review Brazilian research on literacy practices for undergraduate professors. We reviewed SciELO and Portal de Periódicos CAPES. From 2013 to 2019, 20 articles were retrieved and fulfilled inclusion criteria. Studies’ main statements were interpreted using a dialogical analysis of the discourse method. Few studies directly addressed the association between literacy practices and undergraduate professional training in Brazilian higher education. Among these studies, there was a predominance of the procedural technical guidance method, which seeks to improve reading and writing practices in undergraduate courses, particularly for human sciences. The relevance of literacy while becoming a higher education professor in Brazil is discussed in light of previous international research. An interdisciplinary approach, guided by a discursive conception of language, may foster improvements for professors’ practices from different areas of knowledge.
DOI: 10.6084/m9.figshare.19899639
title: Proposal of a digital image analysis method for determining the carbonated front in concretes

description: Abstract Carbonation is one of the most common pathologies in concretes and the correct determination of the depth reached by this process is essential to predict the lifespan of a structure. The most common method for measuring carbonation is to spray a phenolphthalein solution onto the concrete and then measure the colorless area of the solution. Traditionally, such measurement is done manually through visual assessment. However, as this is a subjective assessment, this process is subject to errors. In order to minimize these errors, researchers have used image editing processes and measurements obtained with computerized tools. Even using these programs, the process still depends on the operator’s sensitivity and judgment to determine the areas affected by carbonation. This work proposes a digital analysis with the assignment of phenolphthalein turning pH values in order to obtain the carbonated front limit with greater precision and in a semi-quantitative way. For this, three admixtures of concrete with pozzolans (fly ash and rice husk ash) were analyzed in binary and ternary mixtures submitted to natural carbonation. The proposed method proved to be accurate and efficient as an aid in reading carbonated depths.
DOI: 10.6084/m9.figshare.19899639.v1
title: Proposal of a digital image analysis method for determining the carbonated front in concretes

description: Abstract Carbonation is one of the most common pathologies in concretes and the correct determination of the depth reached by this process is essential to predict the lifespan of a structure. The most common method for measuring carbonation is to spray a phenolphthalein solution onto the concrete and then measure the colorless area of the solution. Traditionally, such measurement is done manually through visual assessment. However, as this is a subjective assessment, this process is subject to errors. In order to minimize these errors, researchers have used image editing processes and measurements obtained with computerized tools. Even using these programs, the process still depends on the operator’s sensitivity and judgment to determine the areas affected by carbonation. This work proposes a digital analysis with the assignment of phenolphthalein turning pH values in order to obtain the carbonated front limit with greater precision and in a semi-quantitative way. For this, three admixtures of concrete with pozzolans (fly ash and rice husk ash) were analyzed in binary and ternary mixtures submitted to natural carbonation. The proposed method proved to be accurate and efficient as an aid in reading carbonated depths.
DOI: 10.6084/m9.figshare.19899650
title: Guidelines for managing complex department store construction projects based on Lean Production and Agile Project Management

description: Abstract Construction projects are becoming increasingly complex. Traditional project management approach does not consider all the complex attributes involved in some projects and assumes that there are general solutions for managing them, without taking into account the specific context in which they are situated. Therefore, there is a need to develop project management methods and tools that consider both the complexity involved and the characteristics of the context. The Lean Production philosophy and the Agile Project Management approach have been pointed out in the literature as two alternatives to support such projects. This paper aims to propose a set of guidelines for managing complex department store construction projects, based on the two theoretical perspectives mentioned above. Using Design Science Research as a methodological approach, an empirical study was carried out in a Brazilian department store enterprise, which is a construction client. The theoretical contribution of this paper is an analysis of the overlaps and complementarities between Lean Production and Agile Project Management.