cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.23648189.v1
title: Plasma Calcium Level and C-Reactive Protein Albumin Ratio Affect Severe Bleeding After Coronary Artery Bypass Grafting

description: ABSTRACT Objective: In this study, we aimed to determine whether plasma calcium level and C-reactive protein albumin ratio (CAR) as well as other demographic and hematological markers are related in predicting severe bleeding after coronary artery bypass grafting (CABG). Methods: A total of 227 adult patients who underwent CABG at our hospital between December 2021 and June 2022 were prospectively studied. Total amount of chest tube drainage was evaluated within the first 24 hours postoperatively or until the patient was re-explored for bleeding. The patients were divided into two groups - Group 1, patients with low amount of bleeding (n=174), and Group 2, patients with severe bleeding (n=53). Univariate and multivariate regression analyzes were performed to determine independent parameters related to severe bleeding within the first 24 hours after surgery. Results: When the groups were compared in terms of demographic, clinical, and preoperative blood parameters; cardiopulmonary bypass time and serum C-reactive protein (CRP) levels were found to be significantly higher in Group 2 compared to the low bleeding group. In addition, lymphocytes, hemoglobin, calcium, albumin, and CAR were found to be significantly lower in Group 2. In multivariate analysis, calcium, albumin, CRP, and CAR were found to be independent predictors of significant association with excessive bleeding. A cut-off value of 8.7 (94.3% sensitivity and 94.8% specificity) for calcium and 0.155 (75.4% sensitivity and 80.4% specificity) for CAR predicted excessive bleeding. Conclusion: Plasma calcium level, CRP, albumin, and CAR can be used to predict severe bleeding after CABG.
DOI: 10.6084/m9.figshare.22121274
title: Care trajectories of COVID-19 patients: from preventive measures to rehabilitation

description: This study aims to analyze the care trajectories of patients diagnosed with COVID-19 who were hospitalized and are currently undergoing rehabilitation regarding their use of and access to the healthcare network (HN). An evaluative, qualitative study was carried out based on interviews with patients in the city of Niterói, Rio de Janeiro State, Brazil. The care trajectories were reconstructed at three different occasions that express their experiences with the healthcare and support network during the pandemic: prevention, support and diagnosis measures; hospitalization; post-COVID-19 care, rehabilitation and support. The results indicate that the main source of information about COVID-19 was TV newscasts. Preventive hygiene measures were the most widely adopted. The family was the main support network. There was no waiting time for admission to the municipal referral hospital. Hospitalization was very well evaluated in terms of user embracement, multidisciplinary care, virtual visits and daily contact between doctor and family members. A post-discharge “care vacuum” was identified, with no follow-up by primary health care (PHC) and other public services. Low-cost health insurance plans and private specialized post-COVID-19 services were frequently and spontaneously sought until the implementation of the rehabilitation service. In summary, solitary and discontinuous care trajectories of individuals and families shed light on several challenges to the health system, including guaranteed access to coordinated PHC and expanded offer of specialized public services and rehabilitation, aligned with the principles of humanized care, in addition to the maintenance of social support measures.
DOI: 10.6084/m9.figshare.22121274.v1
title: Care trajectories of COVID-19 patients: from preventive measures to rehabilitation

description: This study aims to analyze the care trajectories of patients diagnosed with COVID-19 who were hospitalized and are currently undergoing rehabilitation regarding their use of and access to the healthcare network (HN). An evaluative, qualitative study was carried out based on interviews with patients in the city of Niterói, Rio de Janeiro State, Brazil. The care trajectories were reconstructed at three different occasions that express their experiences with the healthcare and support network during the pandemic: prevention, support and diagnosis measures; hospitalization; post-COVID-19 care, rehabilitation and support. The results indicate that the main source of information about COVID-19 was TV newscasts. Preventive hygiene measures were the most widely adopted. The family was the main support network. There was no waiting time for admission to the municipal referral hospital. Hospitalization was very well evaluated in terms of user embracement, multidisciplinary care, virtual visits and daily contact between doctor and family members. A post-discharge “care vacuum” was identified, with no follow-up by primary health care (PHC) and other public services. Low-cost health insurance plans and private specialized post-COVID-19 services were frequently and spontaneously sought until the implementation of the rehabilitation service. In summary, solitary and discontinuous care trajectories of individuals and families shed light on several challenges to the health system, including guaranteed access to coordinated PHC and expanded offer of specialized public services and rehabilitation, aligned with the principles of humanized care, in addition to the maintenance of social support measures.
DOI: 10.6084/m9.figshare.23659246
title: RT-qPCR-based pool testing for the diagnosis of COVID-19

description: ABSTRACT This study proposes a strategy for large-scale testing among a large number of people for the early diagnosis of COVID-19 to elucidate the epidemiological situation. Pool testing involves the analysis of pooled samples. This study aimed to discuss a reverse transcription technique followed by quantitative real-time polymerase chain reaction using pool testing to detect SARS-CoV-2 in nasopharyngeal swab samples. The study proposes an innovative diagnostic strategy that contributes to resource optimization, cost reduction, and improved agility of feedback from results.
DOI: 10.6084/m9.figshare.23659246.v1
title: RT-qPCR-based pool testing for the diagnosis of COVID-19

description: ABSTRACT This study proposes a strategy for large-scale testing among a large number of people for the early diagnosis of COVID-19 to elucidate the epidemiological situation. Pool testing involves the analysis of pooled samples. This study aimed to discuss a reverse transcription technique followed by quantitative real-time polymerase chain reaction using pool testing to detect SARS-CoV-2 in nasopharyngeal swab samples. The study proposes an innovative diagnostic strategy that contributes to resource optimization, cost reduction, and improved agility of feedback from results.
DOI: 10.6084/m9.figshare.23659247
title: ECG Tutor: a gamified intelligent tutoring system for electrocardiogram teaching

description: Abstract: Introduction: New methodological approaches have been suggested in an attempt to improve the acquisition of skills in electrocardiogram (ECG) interpretation, known to be complex and difficult to assimilate. Considering the expansion of active methodologies and the encouragement of technological innovations for medical education, the use of internet technologies (e-learning) has gained strength, highlighting the use of artificial intelligence platforms, such as intelligent tutoring systems (ITS), for their capacity to promote adaptive instruction. Researchers have used gamification (game design techniques) in conjunction with ITS, reporting greater engagement. Objective: Seeking to improve ECG learning performance among medical students through the development of new methodologies and considering the benefits of ITS and the use of gamification in medical education, the present study aimed to explore the interest and motivation of medical students in the use joint use of these technologies to study ECG. Method: This is an exploratory, quantitative study, in which graphic design prototypes of a gamified ECG instructor ITS were created by teachers of the medical course and evaluated by medical students from a public university and another private university after improvement into an interactive format, with the contribution of an interdisciplinary team. Result: At first, 53 undergraduate students from the 5th to the 11th semesters of the course participated in the study. That number was reduced to 14 in the second stage. The analysis showed approval of aspects related to perceived easy-to-use format, perceived usefulness, attitude towards use and intention to use. On the other hand, an urgent need to adapt to mobile devices and improve gamification and aesthetic elements was observed. Conclusion: The obtained results allowed us to conclude that medical students intend to use the ECG Tutor in the future, implying the need to develop a computational solution for the system and measure its impact on student learning.
DOI: 10.6084/m9.figshare.23659247.v1
title: ECG Tutor: a gamified intelligent tutoring system for electrocardiogram teaching

description: Abstract: Introduction: New methodological approaches have been suggested in an attempt to improve the acquisition of skills in electrocardiogram (ECG) interpretation, known to be complex and difficult to assimilate. Considering the expansion of active methodologies and the encouragement of technological innovations for medical education, the use of internet technologies (e-learning) has gained strength, highlighting the use of artificial intelligence platforms, such as intelligent tutoring systems (ITS), for their capacity to promote adaptive instruction. Researchers have used gamification (game design techniques) in conjunction with ITS, reporting greater engagement. Objective: Seeking to improve ECG learning performance among medical students through the development of new methodologies and considering the benefits of ITS and the use of gamification in medical education, the present study aimed to explore the interest and motivation of medical students in the use joint use of these technologies to study ECG. Method: This is an exploratory, quantitative study, in which graphic design prototypes of a gamified ECG instructor ITS were created by teachers of the medical course and evaluated by medical students from a public university and another private university after improvement into an interactive format, with the contribution of an interdisciplinary team. Result: At first, 53 undergraduate students from the 5th to the 11th semesters of the course participated in the study. That number was reduced to 14 in the second stage. The analysis showed approval of aspects related to perceived easy-to-use format, perceived usefulness, attitude towards use and intention to use. On the other hand, an urgent need to adapt to mobile devices and improve gamification and aesthetic elements was observed. Conclusion: The obtained results allowed us to conclude that medical students intend to use the ECG Tutor in the future, implying the need to develop a computational solution for the system and measure its impact on student learning.
DOI: 10.6084/m9.figshare.22633858.v1
title: Cxxc finger protein 1 maintains homeostasis and function of intestinal group 3 innate lymphoid cells with aging

description: Taken together, our findings highlight the influence of Cxxc1-maintained H3K4me3 on innate lymphocyte homeostasis and function during aging, and suggest that targeting intestinal ILC3 may pave the way for novel strategies to improve the fight against age-related infections. To our knowledge, this is the first report revealing the biological effects of Cxxc1-dependent H3K4me3 in aged gut ILC3s
DOI: 10.6084/m9.figshare.22633858
title: Cxxc finger protein 1 maintains homeostasis and function of intestinal group 3 innate lymphoid cells with aging

description: Taken together, our findings highlight the influence of Cxxc1-maintained H3K4me3 on innate lymphocyte homeostasis and function during aging, and suggest that targeting intestinal ILC3 may pave the way for novel strategies to improve the fight against age-related infections. To our knowledge, this is the first report revealing the biological effects of Cxxc1-dependent H3K4me3 in aged gut ILC3s
DOI: 10.6084/m9.figshare.22800722.v1
title: Transport by circulating myeloid cells drives liposomal accumulation in inflamed synovium

description: Supporting information
DOI: 10.6084/m9.figshare.22800722
title: Transport by circulating myeloid cells drives liposomal accumulation in inflamed synovium

description: Supporting information
DOI: 10.6084/m9.figshare.23659250
title: The representation of women in cinema: a study from state of knowledge research

description: Abstract The research’s theme is the representation of women in cinema, intending to analyze the arguments raised on this theme by qualified research in Brazil, in Portuguese. The importance of the study is justified, mainly, by the influence of cinema in the creation of gender identification processes, also in the legal world (legislatively and judicially). It starts with the following problem: what is the representation of gender in cinema, pointed out by the qualified Brazilian bibliography? The hypothesis sustains that there is a correlation between the results of the Brazilian research and those pointed out by Lauretis, Mulvey and hooks, that is, of having an objectification of the woman, being her represented as an object to the male gaze; in addition, with an underrepresentation of race and consequent exclusion of black and Latino women. It dialogues with the problem and the hypothesis from the epistemology of trial and error, especially to seek to refute the hypothesis raised. The refutation attempt was carried out through a state of knowledge research. As a result, it was not possible to refute the hypothesis raised.
DOI: 10.6084/m9.figshare.23659250.v1
title: The representation of women in cinema: a study from state of knowledge research

description: Abstract The research’s theme is the representation of women in cinema, intending to analyze the arguments raised on this theme by qualified research in Brazil, in Portuguese. The importance of the study is justified, mainly, by the influence of cinema in the creation of gender identification processes, also in the legal world (legislatively and judicially). It starts with the following problem: what is the representation of gender in cinema, pointed out by the qualified Brazilian bibliography? The hypothesis sustains that there is a correlation between the results of the Brazilian research and those pointed out by Lauretis, Mulvey and hooks, that is, of having an objectification of the woman, being her represented as an object to the male gaze; in addition, with an underrepresentation of race and consequent exclusion of black and Latino women. It dialogues with the problem and the hypothesis from the epistemology of trial and error, especially to seek to refute the hypothesis raised. The refutation attempt was carried out through a state of knowledge research. As a result, it was not possible to refute the hypothesis raised.
DOI: 10.6084/m9.figshare.23659253
title: The Protagonists of Education: University Students in the Canary Islands, 1913-1927

description: ABSTRACT The objective of this article is to analyze the significant features of the students of the University Section of the Canary Islands (1913-1927) through the documents of the academic institution. In the context of the time, the establishment of higher education in the Canary Islands (Spain) was complicated. The aspirations of the island elites to have university studies, after various efforts with the intermediation of politicians, journalists, and professors of the high school institute, were achieved in 1913, although they were dependent on the University of Seville. We use the methodology of historical analysis resorting to primary and secondary sources. This research contributes to revealing the singularities of the students in the implantation of university studies in the Canary Islands and enriches the microhistory, while at the same time providing a little-exploited line of research that can be extrapolated to other geographical settings.
DOI: 10.6084/m9.figshare.23659253.v1
title: The Protagonists of Education: University Students in the Canary Islands, 1913-1927

description: ABSTRACT The objective of this article is to analyze the significant features of the students of the University Section of the Canary Islands (1913-1927) through the documents of the academic institution. In the context of the time, the establishment of higher education in the Canary Islands (Spain) was complicated. The aspirations of the island elites to have university studies, after various efforts with the intermediation of politicians, journalists, and professors of the high school institute, were achieved in 1913, although they were dependent on the University of Seville. We use the methodology of historical analysis resorting to primary and secondary sources. This research contributes to revealing the singularities of the students in the implantation of university studies in the Canary Islands and enriches the microhistory, while at the same time providing a little-exploited line of research that can be extrapolated to other geographical settings.
DOI: 10.6084/m9.figshare.22561336.v1
title: Fluid-assisted grain size reduction leads to strain localization in oceanic transform faults

description: These files are EBSD and compositional map data used for this manuscript.
DOI: 10.6084/m9.figshare.22561336
title: Fluid-assisted grain size reduction leads to strain localization in oceanic transform faults

description: These files are EBSD and compositional map data used for this manuscript.
DOI: 10.6084/m9.figshare.23659255
title: Study of antidiabetic activity of two novel Schiff base derived dibromo and dichloro substituted compounds in streptozotocin-nicotinamide-induced diabetic rats: pilot study

description: Abstract Schiff bases are aldehyde-or ketone-like chemical compounds in which an imine or azomethine group replaces the carbonyl group. Such compounds show various beneficial biological activities, such as anti-inflammation and antioxidants. The present study addresses comprehensiveevaluation of antidiabetic effect of two novel dibromides and dichlorides substituted Schiff bases substituted Schiff bases (2,2'-[1,2-cyclohexanediylbis (nitriloethylidyne)]bis[4-chlorophenol] (CNCP) and 2, 2'-[1,2-cyclohexanediylbis(nitriloethylidyne)]bis[4-bromophenol] (CNBP) with two different doses, high (LD) and low (LD) in streptozotocin and nicotinamide induced diabetic rats. The rats were separated into normal, untreated, treated and reference groups. Except for the normal group, diabetes traits were induced in the rest animals. Insulin level was measured, and the effect of the compounds on biochemical parameters of liver function and lipid profile were evaluated. High glucose and decreased insulin level are observed in the groups. The histological evaluation confirms that the hepatic architecture in the treated animals with a low dose of CNCP is quite similar to that of the normal hepatic structure and characterized by normal central vein, hepatocytes without any fatty alterations and mild red blood cell infiltration. CNCP (LD) and CNBP (HD) are more successful in enhancing cell survival in the diabetic rat’s liver and can be responsible for causing much healthier structure and notable morphology improvement.
DOI: 10.6084/m9.figshare.23659255.v1
title: Study of antidiabetic activity of two novel Schiff base derived dibromo and dichloro substituted compounds in streptozotocin-nicotinamide-induced diabetic rats: pilot study

description: Abstract Schiff bases are aldehyde-or ketone-like chemical compounds in which an imine or azomethine group replaces the carbonyl group. Such compounds show various beneficial biological activities, such as anti-inflammation and antioxidants. The present study addresses comprehensiveevaluation of antidiabetic effect of two novel dibromides and dichlorides substituted Schiff bases substituted Schiff bases (2,2'-[1,2-cyclohexanediylbis (nitriloethylidyne)]bis[4-chlorophenol] (CNCP) and 2, 2'-[1,2-cyclohexanediylbis(nitriloethylidyne)]bis[4-bromophenol] (CNBP) with two different doses, high (LD) and low (LD) in streptozotocin and nicotinamide induced diabetic rats. The rats were separated into normal, untreated, treated and reference groups. Except for the normal group, diabetes traits were induced in the rest animals. Insulin level was measured, and the effect of the compounds on biochemical parameters of liver function and lipid profile were evaluated. High glucose and decreased insulin level are observed in the groups. The histological evaluation confirms that the hepatic architecture in the treated animals with a low dose of CNCP is quite similar to that of the normal hepatic structure and characterized by normal central vein, hepatocytes without any fatty alterations and mild red blood cell infiltration. CNCP (LD) and CNBP (HD) are more successful in enhancing cell survival in the diabetic rat’s liver and can be responsible for causing much healthier structure and notable morphology improvement.
DOI: 10.6084/m9.figshare.23659256
title: The social representations of vaccines in the context of Science and Health Education in Elementary School

description: Abstract In this paper, we are committed to the theoretical-methodological framework of Social Representations and aim to present a cognitive-structural study of the social representations of vaccines expressed by a group of 7th-grade elementary school students, underscoring the relevance of these studies in pedagogical actions anchored in dealing with socioscientific issues that permeate the relationship between Science and Health Education. Starting with the evocation of words, through the structural approach of the Central Core Theory, we point to a representational arrangement underlined by the importance of vaccines in disease prevention and health preservation, which nonetheless causes pain to and frightens students. In view of the analysis, we intend to build pathways for the relevance of studies dedicated to understanding the forms of everyday knowledge while conducting teaching and learning processes from the perspective of (re)signification of the relationships between Science Teaching and Health Education.
DOI: 10.6084/m9.figshare.23659256.v1
title: The social representations of vaccines in the context of Science and Health Education in Elementary School

description: Abstract In this paper, we are committed to the theoretical-methodological framework of Social Representations and aim to present a cognitive-structural study of the social representations of vaccines expressed by a group of 7th-grade elementary school students, underscoring the relevance of these studies in pedagogical actions anchored in dealing with socioscientific issues that permeate the relationship between Science and Health Education. Starting with the evocation of words, through the structural approach of the Central Core Theory, we point to a representational arrangement underlined by the importance of vaccines in disease prevention and health preservation, which nonetheless causes pain to and frightens students. In view of the analysis, we intend to build pathways for the relevance of studies dedicated to understanding the forms of everyday knowledge while conducting teaching and learning processes from the perspective of (re)signification of the relationships between Science Teaching and Health Education.