cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.11267114.v1
title: Determining the pathogenicity of CFTR missense variants: Multiple comparisons of in silico predictors and variant annotation databases

description: Abstract Pathogenic variants in the Cystic Fibrosis Transmembrane Conductance Regulator gene (CFTR) are responsible for cystic fibrosis (CF), the commonest monogenic autosomal recessive disease, and CFTR-related disorders in infants and youth. Diagnosis of such diseases relies on clinical, functional, and molecular studies. To date, over 2,000 variants have been described on CFTR (~40% missense). Since few of them have confirmed pathogenicity, in silico analysis could help molecular diagnosis and genetic counseling. Here, the pathogenicity of 779 CFTR missense variants was predicted by consensus predictor PredictSNP and compared to annotations on CFTR2 and ClinVar. Sensitivity and specificity analysis was divided into modeling and validation phases using just variants annotated on CFTR2 and/or ClinVar that were not in the validation datasets of the analyzed predictors. After validation phase, MAPP and PhDSNP achieved maximum specificity but low sensitivity. Otherwise, SNAP had maximum sensitivity but null specificity. PredictSNP, PolyPhen-1, PolyPhen-2, SIFT, nsSNPAnalyzer had either low sensitivity or specificity, or both. Results showed that most predictors were not reliable when analyzing CFTR missense variants, ratifying the importance of clinical information when asserting the pathogenicity of CFTR missense variants. Our results should contribute to clarify decision making when classifying the pathogenicity of CFTR missense variants.
DOI: 10.6084/m9.figshare.11267090.v1
title: Relationship between right atrium area and right ventricular ejection fraction on magnetic resonance imaging: comparison with other prognostic markers in patients with pulmonary arterial hypertension

description: Abstract Objective: To compare the right atrium (RA) area and right ventricular ejection fraction (RVEF) with other known prognostic markers in patients with pulmonary arterial hypertension (PAH). Materials and Methods: This was a retrospective study of 74 patients diagnosed with PAH by right heart catheterization at a referral center between January 2018 and May 2018. All of the patients underwent cardiac magnetic resonance imaging (MRI) within 3 months of the right heart catheterization (RHC), as well as undergoing echocardiography, a 6-minute walk test, and determination of the level of N-terminal pro-brain natriuretic peptide (NT-proBNP) within a month of the RHC. We attempted to determine whether the cardiac MRI-derived RA area correlated with ions between RVEF and RA area measured by that determined by echocardiography, as well as whether the cardiac MRI-derived RA area and RVEF correlated with the 6-minute walk distance and NT-proBNP level. Results: The MRI-derived RA area demonstrated a weak correlation with the pulmonary vascular resistance measured by RHC (r = 0.268; p = 0.055) and a moderate correlation with the NT-proBNP (r = 0.429; p = 0.003). All correlations between clinical characteristics and the RVEF were statistically significant. In the univariate linear analysis, the RVEF showed stronger correlations with the clinical characteristics than did the RA area. Conclusion: In patients with PAH, cardiac MRI-derived RVEF appears to correlate more strongly with other prognostic factors than does RA area.
DOI: 10.6084/m9.figshare.11267111.v1
title: Forces in the accelerated reference system of a pendulum: theoretical study and experimental results

description: Abstract In this work we initially lead a theoretical discussion about the forces acting on a physical pendulum oscillating without friction in an accelerated reference system. Such discussion allows us the statement that if an accelerometer is fixed on the center of oscillation of the pendulum, it will register an oscillating value in the radial axis and a null value in the tangential axis. To illustrate this proposition, we will present two simple situation for verification and then we inquire two instigating questions: a)What will happen to the air bubble of a mason level, if we position the same in the tangential direction while we cradle in a swing of a square? b) If we put a small sphere on oscillating swing, will the sphere be in rest during the oscillation? The answers for this counter intuitive questions are that both, the air bubble and small sphere, will stay in rest in relation to the swing if they are positioned on the center of oscillation of the pendulum. In order to elucidate the above questions, we designed an experimental apparatus composed of a physical pendulum, in which we attached an Arduino microcontroller board, an accelerometer sensor and a Bluetooth module.
DOI: 10.6084/m9.figshare.11267102.v1
title: Protective effects of bark ethanolic extract from Spondias dulcis Forst F. against DNA damage induced by benzo[a]pyrene and cyclophosphamide

description: Abstract This study evaluated the genotoxicity, mutagenicity, antigenotoxicity, and antimutagenicity effects on biochemical parameters of oxidative stress of the Spondias dulcis bark ethanolic extract on mice. The extract was evaluated in the doses of 500, 1000, and 1500 mg/kg bw via gavage. To evaluate the protective effects of the extract, benzo[a]pyrene (B[a]P) and cyclophosphamide (CP) were chosen as DNA damage inducers. Genotoxicity and antigenotoxicity were evaluated by the comet assay. Cytotoxicity, mutagenicity, and antimutagenicity were evaluated by the micronucleus test in bone marrow and peripheral blood. The biochemical parameters of oxidative stress were evaluated by the quantification of catalase activity (CAT) and reduced glutathione (GSH) in total blood, liver and kidney, and malondialdehyde (MDA), in liver and kidney. No genotoxic, cytotoxic, or mutagenic effect was found on mice exposed to the extract. The extract depleted the number of damaged nucleoids in total blood and the number of micronucleus (MN) in both cell types. The extract was able to increase CAT activity and GSH levels and decrease MDA levels after treatment with B[a]P and CP. The results indicate that the S. dulcis extract has potential to be used as preventive compound against DNA damage caused by CP and B[a]P.
DOI: 10.6084/m9.figshare.11267075
title: Exact and inexact differentials in the early development of mechanics and thermodynamics

description: Abstract We give an account and a critical analysis of the use of exact and inexact differentials in the early development of mechanics and thermodynamics, and the emergence of differential calculus and how it was applied to solve some mechanical problems, such as those related to the cycloidal pendulum. The Lagrange equations of motions are presented in the form they were originally obtained in terms of differentials from the principle of virtual work. The derivation of the conservation of energy in differential form as obtained originally by Clausius from the equivalence of heat and work is also examined.
DOI: 10.6084/m9.figshare.11267081
title: Estimation of the depth of cracks in concrete through the velocity of ultrasonic waves

description: ABSTRACT Cracks are the most recurrent pathological manifestations in concrete, due to the different forms of exposure that the material is subject to. In this scenario, it is important that buildings undergo inspections through different methods, among which non-destructive testing (NDT) appear as an alternative tool. Among the NDTs, the ultrasonic wave propagation velocity test, known as Ultrasound, was used in this study. The purpose of this study was to evaluate the application of the method in concrete prisms to estimate the depth of cracks using a mathematical model in the literature. The influence of the test distance was also evaluated. The results were compared with the depths simulated in the concrete prisms, using a statistical analysis. It was noticed that the ultrasound test is effective to detect the presence of cracks, as it changes the propagation time of the wave. The mathematical model tested, with the use of ultrasound, was able to estimate the depth of the cracks in 88.5% of cases, but with very dispersed results and a high margin of error, making it impossible to apply them to real structures. It was concluded that the distances of execution of up to 20 cm presented better results.
DOI: 10.6084/m9.figshare.11267087
title: Soil-cement masonry brick production and construction process mapping for social interest housing

description: ABSTRACT Sustainability issue is growing more and more, along with the need to reduce the emission of carbon dioxide around the world. So, projects, techniques and materials that don’t harm the environment are gaining ground in research and markets. This work has as main objective a case study of the production and construction process of soil-cement brick, better known as ecological brick, of a SIH (Social Interest Housing) in the city of Limeira-SP. Other pertinent objectives of this research are the mapping of the productive process of the bricks, which are produced by the borrower himself in the brick factory, and the material flow mapping on construction. For this, Lean concepts will be addressed such as: Lean construction and value flow mapping (VSM) will be addressed. The results were satisfactory, so that a reduction without time of production in the ecological pottery of the soil-cement bricks is proposed in almost 50%, using value-flow mapping. It was possible to reduce in two days the time of construction of masonry of soil-cement brick to a residence of approximately 50m2, only to introduce activities in parallel and to use a labor with more efficient way.
DOI: 10.6084/m9.figshare.11267108.v1
title: The Employee Is Always Right: Employee Satisfaction and Corporate Performance in Brazil

description: Abstract I investigate the effect of employee satisfaction on corporate performance based on an extensive dataset of 114,004 online reviews of Brazil’s 1,000 largest listed and unlisted firms from 2013 to 2018 posted at a local subsidiary of Glassdoor. I find that overall employee satisfaction is positively associated with firm performance and that this relationship is likely to be economically relevant. Among the four dimensions of employee well-being, the link with performance is most evident for the dimension on culture, followed by career opportunities. On the other hand, the dimension on compensation and benefits was the least connected with firm performance. Taken together, these results support the view that intrinsic motivators are more relevant for superior performance than extrinsic ones popularized by the carrot and stick approach to management. I also find that the influence of employee satisfaction on performance is likely to be asymmetrical, in the sense that workplaces characterized by low satisfaction among workers are more likely to lead to poor performance than best-in-class companies are likely to produce superior performance. To my knowledge, this is the first paper to document an asymmetrical link between firm value and employee satisfaction, as well the first one to investigate this issue in an emerging economy using online reviews.
DOI: 10.6084/m9.figshare.11267075.v1
title: Exact and inexact differentials in the early development of mechanics and thermodynamics

description: Abstract We give an account and a critical analysis of the use of exact and inexact differentials in the early development of mechanics and thermodynamics, and the emergence of differential calculus and how it was applied to solve some mechanical problems, such as those related to the cycloidal pendulum. The Lagrange equations of motions are presented in the form they were originally obtained in terms of differentials from the principle of virtual work. The derivation of the conservation of energy in differential form as obtained originally by Clausius from the equivalence of heat and work is also examined.
DOI: 10.6084/m9.figshare.11267087.v1
title: Soil-cement masonry brick production and construction process mapping for social interest housing

description: ABSTRACT Sustainability issue is growing more and more, along with the need to reduce the emission of carbon dioxide around the world. So, projects, techniques and materials that don’t harm the environment are gaining ground in research and markets. This work has as main objective a case study of the production and construction process of soil-cement brick, better known as ecological brick, of a SIH (Social Interest Housing) in the city of Limeira-SP. Other pertinent objectives of this research are the mapping of the productive process of the bricks, which are produced by the borrower himself in the brick factory, and the material flow mapping on construction. For this, Lean concepts will be addressed such as: Lean construction and value flow mapping (VSM) will be addressed. The results were satisfactory, so that a reduction without time of production in the ecological pottery of the soil-cement bricks is proposed in almost 50%, using value-flow mapping. It was possible to reduce in two days the time of construction of masonry of soil-cement brick to a residence of approximately 50m2, only to introduce activities in parallel and to use a labor with more efficient way.
DOI: 10.6084/m9.figshare.11267054
title: The Right to Education of Students with Disability: the Management of Inclusive Education Policy in Municipal Schools According to the Implementing Agents

description: ABSTRACT: This work sought to investigate the implementation of a public policy for inclusive education in the Municipal Education Network of Corumbá/Mato Grosso do Sul, Brazil, through the actions and perceptions of the implementing agents, both within the Secretariat of Education and the school. We sought to learn how education policies aimed at students with disabilities are implemented and the conditions of assistance to these students in the Municipal Network. As theoretical framework, we used the studies on Middle-Level and Street-Level Bureaucracy to understand the perceptions and interactions among agents. Disability Studies provided us with important keys for interpreting phenomena through the sociological perspective of disability, especially the concept of Ableism. Initially, we conducted a survey on enrollment and schools from the School Census. Then, a survey was applied to the management teams and teachers of all urban schools of the Municipal Network, from which three schools were chosen for qualitative research. The results showed that the implementing agents, despite their efforts to carry out the work, found difficulties that interfere directly with their performance.
DOI: 10.6084/m9.figshare.11267057
title: The value of the watershed protection service

description: ABSTRACT Conservation Units are Protected Areas that continuously provide environmental services to society. An example is the Public Water Supply Watershed Protection Service (SPM). As provided in art. 47, Law 9.985 of 2000 (BRASIL, 2004b), the National System of Conservation Units (SNUC): should contribute financially to the protection and implementation of the unit those users of water resources that benefit from the protection afforded by it. The payment for environmental services that the protected area deserves should be valued with the participation of all users, who should be aware of the value of the ecosystem services provided and the consequences of losing such services. Valuing this service is the goal of this work.
DOI: 10.6084/m9.figshare.11267081.v1
title: Estimation of the depth of cracks in concrete through the velocity of ultrasonic waves

description: ABSTRACT Cracks are the most recurrent pathological manifestations in concrete, due to the different forms of exposure that the material is subject to. In this scenario, it is important that buildings undergo inspections through different methods, among which non-destructive testing (NDT) appear as an alternative tool. Among the NDTs, the ultrasonic wave propagation velocity test, known as Ultrasound, was used in this study. The purpose of this study was to evaluate the application of the method in concrete prisms to estimate the depth of cracks using a mathematical model in the literature. The influence of the test distance was also evaluated. The results were compared with the depths simulated in the concrete prisms, using a statistical analysis. It was noticed that the ultrasound test is effective to detect the presence of cracks, as it changes the propagation time of the wave. The mathematical model tested, with the use of ultrasound, was able to estimate the depth of the cracks in 88.5% of cases, but with very dispersed results and a high margin of error, making it impossible to apply them to real structures. It was concluded that the distances of execution of up to 20 cm presented better results.
DOI: 10.6084/m9.figshare.11267054.v1
title: The Right to Education of Students with Disability: the Management of Inclusive Education Policy in Municipal Schools According to the Implementing Agents

description: ABSTRACT: This work sought to investigate the implementation of a public policy for inclusive education in the Municipal Education Network of Corumbá/Mato Grosso do Sul, Brazil, through the actions and perceptions of the implementing agents, both within the Secretariat of Education and the school. We sought to learn how education policies aimed at students with disabilities are implemented and the conditions of assistance to these students in the Municipal Network. As theoretical framework, we used the studies on Middle-Level and Street-Level Bureaucracy to understand the perceptions and interactions among agents. Disability Studies provided us with important keys for interpreting phenomena through the sociological perspective of disability, especially the concept of Ableism. Initially, we conducted a survey on enrollment and schools from the School Census. Then, a survey was applied to the management teams and teachers of all urban schools of the Municipal Network, from which three schools were chosen for qualitative research. The results showed that the implementing agents, despite their efforts to carry out the work, found difficulties that interfere directly with their performance.
DOI: 10.6084/m9.figshare.11267057.v1
title: The value of the watershed protection service

description: ABSTRACT Conservation Units are Protected Areas that continuously provide environmental services to society. An example is the Public Water Supply Watershed Protection Service (SPM). As provided in art. 47, Law 9.985 of 2000 (BRASIL, 2004b), the National System of Conservation Units (SNUC): should contribute financially to the protection and implementation of the unit those users of water resources that benefit from the protection afforded by it. The payment for environmental services that the protected area deserves should be valued with the participation of all users, who should be aware of the value of the ecosystem services provided and the consequences of losing such services. Valuing this service is the goal of this work.
DOI: 10.6084/m9.figshare.11267036
title: The Workers’ Mental Health Care Project of Universidade Federal do Rio de Janeiro - Prasmet: 20 years

description: Abstract Introduction: the Workers’ Mental Health Care Project (Prasmet), conducted by the Universidade Federal do Rio de Janeiro, is as a concentrated effort in the Worker’s Health field to produce knowledge on mental health and work, providing a psychosocial clinic to the workers of one of the largest Brazilian universities. Objectives: to present the history of Prasmet, and to describe the occupational health interventions focused on the university workers. Methods: two axes were described - the first explaining Prasmet actions; and the second about the construction of patients’ profile, based on information about the attention provided to the workers and the clinical characteristics of this population. Results: clinical practice focused on workers’ activities allows health problems to be spatially, temporally and socially contextualized, such as the prevalence of the depression diagnosis group, and of workers with higher risk of illness, as the nursing group. Conclusion: the development of strategies for promotion, rehabilitation and education in occupational health allows institutional approaches of greater magnitude and resolution.
DOI: 10.6084/m9.figshare.11267030
title: Domestic violence against elderly people assisted in primary care

description: ABSTRACT This article aims to investigate the prevalence of domestic violence against elderly people in primary care and possible associated factors. A descriptive, cross-sectional study, with 169 individuals aged 60 years and over, of both sexes, enrolled in the Family Health Units (FHU) of the 4.1 micro region of the city of Recife. Elderly people with health impairment that compromised communication and/or cognition were excluded. The data were collected through interviews in the homes or FHU, with socio-demographic issues, self-perceived health and the research instrument to evaluate possible situations of violence, which was developed and validated in Puerto Rico and adopted by the Ministry of Health. There were 133 elderly people with indicative signs of at least one type of violence in their domestic environment, representing a prevalence of 78.7%, with negligence as the most prevalent type (58.5%), followed by psychological (21.5%) and financial (14%). The elderly interviewed who classified their health as regular/poor have this increased risk. The study reinforces the hypothesis of the existence of domestic violence against the elderly. Thus, identifying its prevalence is the first step in addressing this public health problem.
DOI: 10.6084/m9.figshare.11267024
title: Titanium dioxide (TiO2) as a marker to estimate fecal output in sheep

description: ABSTRACT: Titanium dioxide (TiO2) is an external marker used to estimate fecal output based on forage intake of grazing ruminants; however, its use as marker for grazing sheep still needs attention. In the present study the TiO2 role to estimate fecal output of sheep grazing annual ryegrass was tested. Two essays were conducted in sequence using the same forage and animals. Six lacaune lambs were housed in metabolic cages. Lambs were administered 1 g TiO2 in a single (at 8:30 am, essay 1), or in two daily doses (at 8:30 am and 4:30 pm, essay 2). In both essays the TiO2 administration was followed by a 7-day period to stabilize the fecal excretion of the marker and then by a 5-day period for total collection of feces. Observed and TiO2-based estimated fecal outputs were compared, with or without correction for TiO2 fecal recovery rate (kTiO2). The kTiO2 was around 1.0 and the estimated fecal outputs were similar to the observed ones (p&gt;0.05), regardless the number of daily doses. These results suggested that TiO2, administered in single or two daily doses, can be used as an external marker in grazing sheep.