cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.25402/fsoa.11907210.v1
title: Supplementary Materials - Antitumor activity of new chemical compounds in triple negative mammary adenocarcinoma models

description: Aims. According to the need for the development of new anticancer agents, we have synthetized novel bioactive compounds and aimed to determine their antitumor action. <br>Materials & Methods. We describe in vitro studies evaluating the effect of 35 novel chemical compounds on two triple negative murine mammary adenocarcinoma tumors. <br>Results & Conclusions. Three compounds were selected because of their high antitumor activity and their low toxicity to normal cells. Their effect on tumor cells apoptosis, clonogenicity and migratory capacity, were determined. We found that the selected compounds showed inhibition of viability and clonogenic capacity, and promotion of apoptosis. They also decreased the migratory capacity of tumor cells. The results obtained suggest the likelihood of their future use as antitumor and/or antimetastatic agents

<br>SM1: Methodology and characterization of the chemical compounds SM2: Chemical structure of the compounds belonging to each familySM3: Effect of the compounds (100 µM) on 4T1 cells viability. Cells were incubated for 36 hs in complete medium with 100 µM of each compound. Viable cell number was evaluated with WST-1. Results are shown as percentage of cell viability relative to the non-treated control (100%) and expressed as mean ± SEM. Experiments were performed in triplicate.SM4: Effect of the compounds (75 µM) on 4T1 cells viability. Cells were incubated for 36 hs in complete medium with 75 µM of each compound. Viable cell number was evaluated with WST-1. Results are shown as percentage of cell viability relative to the non-treated control (100%) and expressed as mean ± SEM. Experiments were performed in triplicate. SM5: Effect of the compounds (50 and 25 µM) on 4T1 cells viability. A) Cells were incubated for 36 hs in complete medium with 50 µM of each compound; B) Cells were incubated for 36 hs in complete medium with 25 µM of each compound. Viable cell number was evaluated with WST-1. Results are shown as percentage of cell viability relative to the non-treated control (100%) and expressed as mean ± SEM. Experiments were performed in triplicate. SM6: The percent of viability of the selected compounds at 25 µM<br>
DOI: 10.25402/fvl.23295275
title: Association between human Epstein–Barr virus and brain cancer: a systematic review and meta-analysis – Supplementary files

description: Aim: The aim of this study was to investigate the pooled prevalence and potential correlation between
Epstein–Barr virus (EBV) infection and brain cancers. Materials & methods: We searched for relevant
studies in main databases and analyzed the heterogeneity, odds ratio and corresponding 95% CI among
all studies using STATA software V.14. Results: Fourteen articles were included in the meta-analysis.
The pooled prevalence of EBV among brain cancer patients was 9% (95% CI: 3–16%; I2 = 91.06%).
An association was found between EBV and brain cancer (OR: 6.90 [95% CI: 1.81–26.28]; I2 = 0%]).
Conclusion: The results of this study indicate a significant association between EBV infection and brain
cancer, suggesting EBV infection is a potential risk factor for brain cancer development.
DOI: 10.25402/fsoa.13311941
title: Supplementary data: Overcoming negative predictions of MicroRNA expressions to gemcitabine response with FOLFIRINOX in advanced pancreatic cancer patients

description: FOLFIRINOX
 is superior to gemcitabine in patients with pancreatic cancer, but this
 regimen is associated with toxicity and biomarkers for response are
 warranted. MicroRNAs can mediate drug resistance and could provide predictive
 information. Altered expressions of several microRNAs including miR-21-5p,
 miR-10b-5p, and miR-34a-5p have been previously linked to a worse response to
 gemcitabine. We investigated the influence of expression levels in tumor
 tissue of those three microRNAs on outcome to FOLFIRINOX. Twenty-nine
 patients with sufficient formalin-fixed paraffin-embedded tumor tissue were
 identified. There was no significant association between high and low
 expression groups for these three microRNA. We conclude that polychemotherapy
 combination can overcome intrinsic negative prognostic factors.
DOI: 10.25402/fsoa.13311941.v1
title: Supplementary data: Overcoming negative predictions of MicroRNA expressions to gemcitabine response with FOLFIRINOX in advanced pancreatic cancer patients

description: FOLFIRINOX
 is superior to gemcitabine in patients with pancreatic cancer, but this
 regimen is associated with toxicity and biomarkers for response are
 warranted. MicroRNAs can mediate drug resistance and could provide predictive
 information. Altered expressions of several microRNAs including miR-21-5p,
 miR-10b-5p, and miR-34a-5p have been previously linked to a worse response to
 gemcitabine. We investigated the influence of expression levels in tumor
 tissue of those three microRNAs on outcome to FOLFIRINOX. Twenty-nine
 patients with sufficient formalin-fixed paraffin-embedded tumor tissue were
 identified. There was no significant association between high and low
 expression groups for these three microRNA. We conclude that polychemotherapy
 combination can overcome intrinsic negative prognostic factors.
DOI: 10.25402/fvl.23716386.v1
title: Inpatient and outpatient costs associated with respiratory syncytial virus in Japanese infants and older adults: Supplementary data

description: Objective: To evaluate healthcare resource use for respiratory syncytial virus (RSV) in Japan. Methods:
Using JMDC and Medical Data Vision (MDV) claims databases, we retrospectively evaluated cost and length
of hospital/intensive care unit stays in RSV-diagnosed cohorts of infants (&lt;12 months) and older adults
(OAs, ≥60 years). We analyzed the usage and costs of palivizumab in infants. Results: Mean costs among
those hospitalized were $2823 (USD); $2851; and $6609 (¥131 [JPY]/$) in JMDC-infant (n = 13,752); MDVinfant
(n = 22,142); and MDV-OA cohorts (n = 165), respectively. The mean cost was higher in those aged
&lt;1 month, with risk factors, and severe RSV disease. Mean cumulative cost of palivizumab prophylaxis in
JMDC infant cohort was $6796/year. Conclusion: RSV causes enormous economic burden in infants and
OAs.
DOI: 10.25402/fsoa.14636109
title: Supplementary_tables: Prognostic implications of PD-L1 expression in patients with angiosarcoma

description: Background: There are limited data on the feasibility of
programmed death ligand-1 (PD-L1) expression as a prognostic biomarker in
metastatic angiosarcoma. Materials & Methods: We retrospectively collected
and analyzed the data on PD-L1 expression in 70 angiosarcoma patients who were
diagnosed at our center between 2005 and 2019. Results: Thirteen (19%) patients
had PD-L1 expression. Metastatic angiosarcoma patients who were PD-L1-negative
(n=24) showed longer median progression-free survival (4.9 vs. 1.6 months;
p=0.04) and median overall survival (OS; 10.9 vs. 5.4 months; p=0.01) than
those who were PD-L1-positive (n=4). PD-L1 status proved to be a significant
factor for OS. Conclusions: Metastatic angiosarcoma patients with PD-L1
expression showed shorter survival. PD-L1 status is an independent prognostic
factor for OS in metastatic angiosarcoma patients.
DOI: 10.25402/fsoa.14730390.v1
title: Supplementary tables: A municipality environmental pressure index as a geo-stratification tool for human and environmental monitoring studies.docx

description: Supplementary Table 1. Municipal pressure
 indices of all municipalities in the Campania Region
 Supplementary
 table 2. Identification of Clusters within the Impact Areas applicable to the
 geo-stratified recruitment plan as part of a monitoring study in the Campania
 Region
 
 
 




Abstract: 
The Experimental Zooprophylactic Institute of Southern Italy (Istituto
Zooprofilattico Sperimentale del Mezzogiorno – IZSM) is a public health
institution operating within the Italian National Health Service. Over the past
five years, IZSM has promoted several researches and interventions in an effort
to tackle the “Land of Fires” phenomenon, caused by the continued trafficking
and uncontrolled incineration of waste that has affected some areas of Campania
for decades. In this article, a mathematical model that generates a
municipality index of environmental pressure is presented. The model was
developed by a multi-disciplinary team led by an environmental engineer, which
included researchers in the fields of veterinary and human medicine, biology
and computer science. This model may
serve as a geo-stratification tool useful for the design of human biomonitoring
studies, although it may also be employed for strategic planning of remediation
programs and public health interventions.
DOI: 10.25402/fsoa.16863301.v1
title: Supplementary table 2.xlsx: Public attitudes in Japan toward the reproductive use of gametes derived from human-induced pluripotent stem cells

description: <b>Supplementary
 Table 2</b>. 
 Comparison
 between a subgroup of respondents aged 49 or younger that had undergone
 infertility treatments and another group of all other respondents regarding
 acceptance by purposes
DOI: 10.25402/fsoa.16863307.v1
title: Supplementary material.docx: Public attitudes in Japan toward the reproductive use of gametes derived from human-induced pluripotent stem cells

description: <b>Supplementary
 Table 1</b>. 
 Comparison
 between a subgroup of respondents aged 49 or younger that had undergone
 infertility treatment, and another group of all the other respondents
 regarding personal preferences in using IVD-gametes for reproduction
 
 <b>Supplementary
 Table 2</b>. 
 Comparison
 between a subgroup of respondents aged 49 or younger that had undergone
 infertility treatments and another group of all other respondents regarding
 acceptance by purposes
 
 <b>Supplementary
 Box 1</b>
 Explanation
 regarding induced pluripotent stem cells (iPSCs) and research for creating
 sperm/ova from human induced pluripotent stem cells (hiPSCs)
DOI: 10.25402/fsoa.21967019
title: Prognostic significance of the angiopoietin-2 for early prediction of septic shock in severe sepsis patients: supplementary data

description: Aim: The current study investigated the plasma levels of angiopoietin-1/-2 and their association with
clinical outcomes of sepsis. Methods: Angiopoietin-1 and -2 levels were quantified in plasma from 105
patients with severe sepsis by ELISA. Results: Angiopoietin-2 levels elevated according to the severity of
sepsis progression. Angiopoietin-2 levels were correlatedwithmean arterial pressure and platelets counts,
total bilirubin, creatinine, procalcitonin, lactate levels and SOFA score. Angiopoietin-2 levels accurately
discriminated for sepsis with an AUC = 0.97 and septic shock from severe sepsis patients (AUC = 0.778).
Conclusion: Plasma angiopoietin-2 levels may serve as an additional biomarker for severe sepsis and septic
shock.
DOI: 10.25402/fsoa.19842583.v1
title: Prognostic value of Circulating Endothelial Cells (CEC) in Glioblastoma patients: A pilot study – Supplementary Table 1

description:       
Prognostic   value of Circulating Endothelial Cells (CEC) in Glioblastoma patients: A   pilot study.
<strong>Supplementary   Table 1</strong>. 
Clinical and experimental data used in the study.
DOI: 10.25402/fsoa.21967019.v1
title: Prognostic significance of the angiopoietin-2 for early prediction of septic shock in severe sepsis patients: supplementary data

description: Aim: The current study investigated the plasma levels of angiopoietin-1/-2 and their association with
clinical outcomes of sepsis. Methods: Angiopoietin-1 and -2 levels were quantified in plasma from 105
patients with severe sepsis by ELISA. Results: Angiopoietin-2 levels elevated according to the severity of
sepsis progression. Angiopoietin-2 levels were correlatedwithmean arterial pressure and platelets counts,
total bilirubin, creatinine, procalcitonin, lactate levels and SOFA score. Angiopoietin-2 levels accurately
discriminated for sepsis with an AUC = 0.97 and septic shock from severe sepsis patients (AUC = 0.778).
Conclusion: Plasma angiopoietin-2 levels may serve as an additional biomarker for severe sepsis and septic
shock.
DOI: 10.25402/fsoa.22731029.v1
title: Mass spectrometric analysis of bioactive conditioned media of bacteria isolated from reptilian gut: supplementary table

description: Aim: To determine whether selected gut bacteria of crocodile exhibit antibacterial properties. Materials &
methods: Two bacteria isolated from Crocodylus porosus gut were used, namely: Pseudomonas aeruginosa
and Aeromonas dhakensis. Conditioned media were tested against pathogenic bacteria and metabolites
were analyzed using liquid chromatography-mass spectrometry. Results & conclusion: Antibacterial
assays revealed that conditioned media showed potent effects against pathogenic Gram-positive
and Gram-negative bacteria. LC–MS revealed identity of 210 metabolites. The abundant metabolites
were, N-Acetyl-L-tyrosine, Acetaminophen, Trans-Ferulic acid, N, N-Dimethylformamide, Pyrocatechol,
Cyclohexanone, Diphenhydramine, Melatonin, Gamma–terpinene, Cysteamine, 3-phenoxypropionic acid,
Indole-3-carbinol, Benzaldehyde, Benzocaine, 2-Aminobenzoic acid, 3-Methylindole. These findings
suggest that crocodile gut bacteria are potential source of novel bioactive molecules that can be utilized
as pre/post/antibiotics for the benefit of human health.
DOI: 10.15151/esrf-es-1706795788
title: Structural Biology at EMBL Grenoble, IBS-CIBB and IAB

description: This proposal clusters crystallography and bioSAXS projects at the EMBL Grenoble, IBS-CIBB and IAB. It combines groups working on different topics with a major focus on cell signaling proteins, drug discovery, long non-coding RNAs, nucleic acid-protein complexes, and host-pathogen interactions. The proposers have long-standing experience in the use, as well as the development of beam lines for macromolecular crystallography and biological small angle X-ray scattering and have participated in successive BAG applications over the years, mostly at the ESRF but also at other synchrotrons (i.e. Soleil, Petra III, and Diamond). As Stephen Cusack (former head of EMBL Grenoble) will be retiring at the end of 2023 we propose to change the BAG responsible to Andrew McCarthy for this application round.
DOI: 10.15151/esrf-es-1476093796
title: Advanced Photon Source, Sector 21 - The Life Sciences Collaborative Access Team (LS-CAT) - CAT Member Macromolecular Crystallography

description: The Life Sciences Collaborative Access Team (LS-CAT) provides Macromolecular Crystallography support to our CAT members from eight Universities in the USA, including Northwestern University, University of Michigan, Wayne State University, Michigan State University, University Wisconsin, Vanderbilt University, and University of Illinois at Chicago, and also to General Users. With a one-year dark period approaching for the upgrade of the Advanced Photon Source (APS-U), we are seeking beam time for our CAT Member laboratories at ESRF by way of this Block Allocation Group, consisting of a portion of our CAT Member PIs and their laboratory members, in order to keep supporting their research and future funding. LS-CAT is organizing our CAT Members into this BAG Proposal, and other proposals we will submit, in order to streamline the process for our CAT Members, and for the Staff of Lightsources to which we are applying for access to beam time.
DOI: 10.15151/esrf-es-1471245503
title: PROTEINS RELATED TO PATHOGENESIS OF DISEASES, VIRAL PROTEINS, CELL DIVISION, SIGNALLING AND CHROMATIN PROCESSES

description: The outstanding research questions of our BAG focus on proteins and their complexes involved in a variety of processes, ranging from cell homeostasis (from gene regulation to folding quality control, from energy metabolism to signal transduction) to communication and surface recognition (including trans-interactions between cell adhesion molecules, components of the extracellular matrix weaving, as well as antigen-antibody interactions for vaccine development and optimization). Key to several projects is the characterization of the mechanisms associated to enzyme function in various organisms, including bacteria, viruses, plants, animals and humans for downstream drug discovery campaigns. Emphasis is also given to research focusing on engineering protein and enzymes for future industrial applications, as well as to understand the impact of pathogenic mutations on protein structures, providing a genotype-to-molecular phenotype rationale to disease development.
DOI: 10.15151/esrf-es-1473914182
title: Austrian Crystallographic Diffraction Consortium

description: The Austrian Crystallographic Diffraction Consortium (ACDC) BAG aims at supporting several macromolecular structural biology groups across Austria (in total 20 research groups at 9 institutions in 4 cities). We employ mainly the technique of X-ray crystallography to characterize macromolecular biological complexes, but also solution scattering approaches are frequently used to characterize dynamic assemblies. Approval of this BAG will be essential for researchers in all our groups to carry out their structural studies on various health-related and basic research-oriented topics, which are targeted at characterizing large molecular assemblies or proteins currently under-represented in the PDB, including membrane proteins. Corresponding high-resolution diffraction data are only obtainable through the use of synchrotron radiation sources. Thus regular synchrotron access is highly desirable to maintain a competitive advantage in our individual research fields.
DOI: 10.57841/casdc.0003488
title: 石墨烯等离激元在水溶液中的超灵敏中红外生物传感SEM表征
DOI: 10.15151/esrf-es-1612856799
title: Protein dynamics of resurrected ancestral enzymes studied by crystallography

description: Adaptation of organisms to environmental niches is a hallmark of evolution. One prevalent example is that of thermal adaptation, where in two descendants evolve at
different temperature extremes. How dynamical changes due to adaptive mutations are allosterically propagated to the active site, to modulate activity, in different
thermally adapted enzyme is not known. To address this question we analyze the properties of resurrected ancestral enzymes engaged in a thermal adaptation route
we recapitulated. We will solve the crystal structure several billions-years old enzymes and we will explore their dynamical properties following X-rays data
collection at various temperature. We expect describing the evolutionary-driven reorganization of contacts network that are required to conserve appropriate
conformational stability and efficient functional dynamics during the early steps of an enzyme adaptive process.
DOI: 10.15151/esrf-es-1656358630
title: Follow-up experiment - Combined nanoscale strain and halide composition mapping in perovskite layers deposited on silicon for tandem solar c

description: This proposal concerns the very promising technology of tandem solar cells where hybrid halide perovskites (HHP) are used as an active layer on top of a silicon cell. Our aim is to simultaneously map, using the ID13 nano-beam, the strain, lattice orientation and halide distribution by combining XRD and XRF in pristine and aged samples. This will allow to gain fundamental insights into aging mechanisms of HHP films. After a first successful experiment in June 2023, we apply for a follow-up experiment. Samples obtained from two different deposition methods as well as films deposited on different substrates will be studied and compared. The microstructure of all above samples will be investigated in the sample plane. A second focus concerns the study of cross section samples of solar cells prepared in different conditions, in the perspective of depth-resolved studies of the HHP microstructure and halide composition.
DOI: 10.57745/yxw44e
title: Vivre avec le feu : étude des perceptions du risque d’incendie de forêt des usagers du massif des Landes de Gascogne

description: Perception du risque, incendie de forêt, modèles mentaux, culture du risque, résilience territoriale
DOI: 10.15468/dl.6zwd3t
title: Occurrence Download

description: A dataset containing 6 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Echiothrix centrosa",
 "HasCoordinate is TRUE"
 ]
}

 The dataset includes 6 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0027912-251120083545085/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.9kc46z
title: Occurrence Download

description: A dataset containing 235987 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Geometry POLYGON((37.252 0.461,37.988 0.461,37.988 0.969,37.252 0.969,37.252 0.461))",
 "OccurrenceStatus is Present"
 ]
}

 The dataset includes 235987 records from 126 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0027852-251120083545085/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.6084/m9.figshare.30596061
title: Fossil occurrence data used for species-level analyses from Global extinction events and persistent age-dependency in sharks and rays over the past 145 million years

description: Raw data from the FINS dataset filtered to contain only species-level occurrences with age ranges of 15 Myr or less, which were marked as valid based on age and taxonomic evaluation.
DOI: 10.6084/m9.figshare.30596061.v1
title: Fossil occurrence data used for species-level analyses from Global extinction events and persistent age-dependency in sharks and rays over the past 145 million years

description: Raw data from the FINS dataset filtered to contain only species-level occurrences with age ranges of 15 Myr or less, which were marked as valid based on age and taxonomic evaluation.
DOI: 10.6084/m9.figshare.30596064
title: References associated with the fossil occurrence data from Global extinction events and persistent age-dependency in sharks and rays over the past 145 million years

description: List of full references associated with the occurrences from Data S1 and S2.
DOI: 10.6084/m9.figshare.30596064.v1
title: References associated with the fossil occurrence data from Global extinction events and persistent age-dependency in sharks and rays over the past 145 million years

description: List of full references associated with the occurrences from Data S1 and S2.
DOI: 10.6084/m9.figshare.30596067
title: Fossil occurrence data used for genus-level analyses from Global extinction events and persistent age-dependency in sharks and rays over the past 145 million years

description: Raw data from the FINS dataset filtered to contain only species- and genus-level occurrences with age ranges of 15 Myr or less, which were marked as valid based on age and taxonomic evaluation.
DOI: 10.6084/m9.figshare.30596067.v1
title: Fossil occurrence data used for genus-level analyses from Global extinction events and persistent age-dependency in sharks and rays over the past 145 million years

description: Raw data from the FINS dataset filtered to contain only species- and genus-level occurrences with age ranges of 15 Myr or less, which were marked as valid based on age and taxonomic evaluation.
DOI: 10.11583/dtu.30637394
title: Data for Lab-based X-ray CT phase retrieval

description: Datasets used as example of implementation of paganin based phase retrieval of lab CT results recorded on a ZEISS versa 520 CT instrument. Python based implementation of phase retieival algoritms available at: emilv / LabPhase · GitLab.
DOI: 10.11583/dtu.30637394.v1
title: Data for Lab-based X-ray CT phase retrieval

description: Datasets used as example of implementation of paganin based phase retrieval of lab CT results recorded on a ZEISS versa 520 CT instrument. Python based implementation of phase retieival algoritms available at: emilv / LabPhase · GitLab.