cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.19102252.v1
title: The wind that shakes the barley: the role of East Asian cuisines on barley grain size

description: This paper investigates the eastern movements of barley grains and their morphological variations in prehistory. By combining previously published and newly collected archaeobotanical grain measurements (<i>n</i> = 2,176), we explore the roles of culinary traditions underlying the morphological traits observed. We find that barley diminished in size as it moved from its origin in southwestern Asia to Central and East Asia between the third millennium BC and first millennium BC. In particular, the grains in Monsoonal China became greatly reduced in comparison to other regions as the crop was incorporated into eastern small grain cuisines. The reverse pattern is observed in the high-altitude Tibetan environment, which is attributed to the practicalities of cooking under low vapour pressure conditions. These results, demonstrating that barley moved eastward but western grinding and baking traditions did not, reveal the complexity of the eastern culinary system and raise awareness of decoupling of grains and their associated cuisines.
DOI: 10.6084/m9.figshare.23290540.v1
title: Additional file 1 of Non-adherence and non-persistence to intravitreal anti-vascular endothelial growth factor (anti-VEGF) therapy: a systematic review and meta-analysis

description: Additional file 1.
DOI: 10.6084/m9.figshare.8092469
title: Preservation and evaluation of spiced chayote juice using hurdle technology

description: Abstract Chayote (Sechium edule) is a perennial climbing plant, belonging to the Cucurbitaceae family and is neglected or underutilized as a food or as a raw material in the food industry because of its bland taste. This bland taste can be overcome by blending with a suitable substrate such as sugarcane juice along with natural flavouring. However, this blending represents a preservation problem for the spiced juice, since both chayote juice and sugarcane juice are prone to microbial attack. Therefore, an attempt was made in the present study to preserve the spiced chayote juice by employing different hurdles i.e. pasteurization temperature (70 °C and 80 °C) and pasteurization time (10 and 20 min) followed by the addition of different concentrations of potassium metabisulphite (KMS) (200, 300 and 400 ppm). The samples so prepared were filled into glass bottles and stored under refrigeration for forty-five days. As the storage period proceeded there were significant decreases in pH, total protein content, total phenolic compounds, antioxidant activity, reducing power, metal chelation, tannin content, ascorbic acid content and overall acceptability, whereas there were significant increases in TSS (total soluble solids), titratable acidity, reducing sugars, total sugar, TPC (total plate count) and MIC (minimum inhibitory concentration). A cluster analysis of the data revealed that the pasteurization temperature exerted the most significant effect on the physicochemical and sensory characteristics of the spiced chayote juice as compared to the pasteurization time and KMS concentration, which failed to fall into the separate and respective clusters. In a nutshell, it was concluded that spiced chayote juice can be successfully preserved using hurdle technology (pasteurizing at 70 °C for 10 min followed by the addition of 400ppm KMS).
DOI: 10.14272/rjhhgqmrvyaagu-uhfffaoysa-n/chmo0000593
title: 1H nuclear magnetic resonance spectroscopy (1H NMR) ()
title: InChI=1S/C11H13N5O4/c1-3-19-11(18)9-4-12-14-10(9)16-5-8(13-15-16)6-20-7(2)17/h4-5H,3,6H2,1-2H3,(H,12,14)

description: dataset for 1H nuclear magnetic resonance spectroscopy (1H NMR)
 
 1H NMR (400 MHz, DMSO-d6 [2.50 ppm], ppm) δ = 13.97 (s, 1H), 8.59 (s, 1H), 8.55 (s, 1H), 5.21 (s, 2H), 4.10 (q, J = 7.1 Hz, 2H), 2.06 (s, 3H), 1.11 (t, J = 7.1 Hz, 3H).
DOI: 10.6084/m9.figshare.8092163.v1
title: Contrastive Research on Electrical Contact Performance for Contact Materials of Cu-SnO2 and Cu-ZnO2 Alloys

description: Herein, SnO2- and ZnO2-doped (1.5 wt.%) composite Cu powder was prepared by mechanical alloying (MA) respectively, and both the contact materials of oxide-doped Cu alloys were subsequently obtained by canned hot-pressing powder sintering with hot extrusion combined. Scanning electron microscopy (SEM), laser scanning confocal microscopy (LSCM) and self-designed electrical breakdown device were used for investigating the microstructure and properties including electric conductivity and hardness, especially for electrical contact performance of the Cu-SnO2 alloy and in compared with the Cu-ZnO2 alloy. The experimental results show that the hardness of Cu-SnO2 and Cu-ZnO2 contact materials are 103.5±1 HV and 192.7±1 HV, respectively, which meet the hardness standard of national standard electrical contact materials. Meanwhile, the relative conductivity %IACS are 7.24% and 6.20%, respectively, which are higher than the traditional Cu-based contact materials. This electrical life simulation test system was designed independently, and the results indicate that the switching times of Cu-SnO2 contact materials are much more than that of Cu-ZnO2. The addition of SnO2 can effectively improve the arc extinguishing characteristics and the anti-welding performance of the contact materials is enhanced. In summary, SnO2-doped Cu-based contact materials possess excellent comprehensive properties, which can provide reference for potential applications in contact materials.
DOI: 10.14272/rjhhgqmrvyaagu-uhfffaoysa-n/chmo0000596.1
title: distortionless enhancement with polarization transfer (DEPT) ()
title: InChI=1S/C11H13N5O4/c1-3-19-11(18)9-4-12-14-10(9)16-5-8(13-15-16)6-20-7(2)17/h4-5H,3,6H2,1-2H3,(H,12,14)

description: dataset for distortionless enhancement with polarization transfer (DEPT)
DOI: 10.6084/m9.figshare.23290525.v1
title: Additional file 2 of Deep learning classification of uveal melanoma based on histopathological images and identification of a novel indicator for prognosis of patients

description: Additional file 2: Table S2. 379 deep learning (DL) features from histogram of patches likelihood.
DOI: 10.14272/rjhhgqmrvyaagu-uhfffaoysa-n/chmo0000604
title: heteronuclear single quantum coherence (HSQC) ()
title: InChI=1S/C11H13N5O4/c1-3-19-11(18)9-4-12-14-10(9)16-5-8(13-15-16)6-20-7(2)17/h4-5H,3,6H2,1-2H3,(H,12,14)

description: dataset for heteronuclear single quantum coherence (HSQC)
DOI: 10.6084/m9.figshare.23290528
title: Additional file 3 of Deep learning classification of uveal melanoma based on histopathological images and identification of a novel indicator for prognosis of patients

description: Additional file 3: Table S3. The detail parameters for assessment of seven machine learning models.
DOI: 10.14272/rjhhgqmrvyaagu-uhfffaoysa-n/chmo0000470
title: mass spectrometry (MS) ()
title: InChI=1S/C11H13N5O4/c1-3-19-11(18)9-4-12-14-10(9)16-5-8(13-15-16)6-20-7(2)17/h4-5H,3,6H2,1-2H3,(H,12,14)

description: dataset for mass spectrometry (MS)
 
 MS (EI, 70 eV, 140 °C), m/z (%): 279 (1) [M]+, 192 (74), 181 (13), 164 (100), 155 (15), 146 (15), 135 (39), 110 (35), 55 (25).HRMS–EI (C11H13O4N5) (m/z): [M]+ Calcd 279.0962; Found 279.0961.
DOI: 10.14272/rjhhgqmrvyaagu-uhfffaoysa-n/chmo0000595
title: 13C nuclear magnetic resonance spectroscopy (13C NMR) ()
title: InChI=1S/C11H13N5O4/c1-3-19-11(18)9-4-12-14-10(9)16-5-8(13-15-16)6-20-7(2)17/h4-5H,3,6H2,1-2H3,(H,12,14)

description: dataset for 13C nuclear magnetic resonance spectroscopy (13C NMR)
 
 13C NMR (100 MHz, DMSO-d6 [39.5 ppm], ppm) δ = 170.0 (Cq), 160.7 (Cq), 144.3 (Cq), 141.4 (Cq), 134.9 (CH), 127.2 (CH), 107.5 (Cq), 60.0 (CH2), 56.8 (CH2), 20.6 (CH3), 13.8 (CH3).
DOI: 10.6084/m9.figshare.22593044.v1
title: Clinical side-effects based drug repositioning for anti-epileptic activity

description: Several generations of anti-epileptic drugs (AEDs) are available but have several associated side effects apart from a limited success rate. Drug repositioning strategies have gained importance in the last two decades owing to lower failure rates and economic burden. Drugs with similar side effect profiles may share a common mechanism of action and thus can be linked to other disease treatments. The present study was carried out to identify the newly approved drug candidate(s) as AEDs using clinical side-effects drug repositioning strategy. The clinical side effect similarity of drugs available in the SIDER v4.1 database was estimated against common side effects of 5 major marketed AEDs, using the ‘dplyr’ package library in the R. Further drugs were filtered based on Blood Brain Barrier permeability prediction and FDA-approval status. Molecular docking studies were performed for selected 26 hits (drugs) against previously identified epilepsy target receptors: Voltage-gated sodium channel α2 (Nav1.2), GABA receptor α1-β1 (GABAr α1-β1), and Voltage-gated calcium channel α-1 G (Cav3.1). Only 2 drugs (Ziprasidone and Paroxetine) showed better binding affinities against studied epilepsy receptors Nav1.2, GABAr α1-β1, and Cav3.1, than their corresponding standard AEDs, i.e. Carbamazepine, Clonazepam, and Pregabalin, respectively. Ziprasidone reportedly showed seizure-like symptoms in ∼3% of patients and was hence omitted from further study. The MDS study of docked complexes of Paroxetine with selected epilepsy target receptors showed stable RMSD values and better interaction energies. The study reveals Paroxetine as a potential candidate to be repurposed for 1st line epileptic seizure medication. Communicated by Ramaswamy H. Sarma
DOI: 10.14272/rjhhgqmrvyaagu-uhfffaoysa-n/chmo0000596
title: distortionless enhancement with polarization transfer (DEPT) ()
title: InChI=1S/C11H13N5O4/c1-3-19-11(18)9-4-12-14-10(9)16-5-8(13-15-16)6-20-7(2)17/h4-5H,3,6H2,1-2H3,(H,12,14)

description: dataset for distortionless enhancement with polarization transfer (DEPT)
DOI: 10.14272/rjhhgqmrvyaagu-uhfffaoysa-n/chmo0000601
title: heteronuclear multiple bond coherence (HMBC) ()
title: InChI=1S/C11H13N5O4/c1-3-19-11(18)9-4-12-14-10(9)16-5-8(13-15-16)6-20-7(2)17/h4-5H,3,6H2,1-2H3,(H,12,14)

description: dataset for heteronuclear multiple bond coherence (HMBC)
DOI: 10.14272/rjhhgqmrvyaagu-uhfffaoysa-n/chmo0000630
title: infrared absorption spectroscopy (IR) ()
title: InChI=1S/C11H13N5O4/c1-3-19-11(18)9-4-12-14-10(9)16-5-8(13-15-16)6-20-7(2)17/h4-5H,3,6H2,1-2H3,(H,12,14)

description: dataset for infrared absorption spectroscopy (IR)
 
 IR (ATR, ṽ) = 3150 (m), 2941 (w), 2799 (w), 1740 (s), 1717 (vs), 1530 (s), 1466 (w), 1446 (w), 1409 (w), 1383 (m), 1363 (m), 1337 (m), 1306 (m), 1283 (w), 1238 (vs), 1225 (vs), 1183 (m), 1113 (vs), 1085 (s), 1045 (vs), 1023 (vs), 999 (s), 980 (s), 976 (s), 956 (s), 943 (m), 925 (w), 832 (vs), 769 (vs), 693 (w), 662 (w), 637 (w), 620 (w), 609 (w), 575 (s), 565 (w), 518 (w), 477 (w), 456 (w), 398 (w), 391 (w), 384 (w) cm–1.
DOI: 10.6084/m9.figshare.22692258.v1
title: SPP1, a potential therapeutic target and biomarker for lung cancer: functional insights through computational studies

description: NIH reported 128 different types of cancer of which lung cancer is the leading cause of mortality. Globally, it is estimated that on average one in every seventeen hospitalized patients was deceased. There are plenty of studies that have been reported on lung cancer draggability and therapeutics, but yet a protein that plays a central specific to cure the disease remains unclear. So, this study is designed to identify the possible therapeutic targets and biomarkers that can be used for the potential treatment of lung cancers. In order to identify differentially expressed genes, 39 microarray datasets of lung cancer patients were obtained from various demographic regions of the GEO database available at NCBI. After annotating statistically, 6229 up-regulated genes and 10324 down-regulated genes were found. Out of 17 up-regulated genes and significant genes, we selected SPP1 (osteopontin) through virtual screening studies. We found functional interactions with the other cancer-associated genes such as VEGF, FGA, JUN, EGFR, and TGFB1. For the virtual screening studies,198 biological compounds were retrieved from the ACNPD database and docked with SPP1 protein (PDBID: 3DSF). In the results, two highly potential compounds secoisolariciresinol diglucoside (-12.9 kcal/mol), and Hesperidin (-12.0 kcal/mol) showed the highest binding affinity. The stability of the complex was accessed by 100 ns simulation in an SPC water model. From the functional insights obtained through these computational studies, we report that SPP1 could be a potential biomarker and successive therapeutic protein target for lung cancer treatment. Communicated by Ramaswamy H. Sarma
DOI: 10.6084/m9.figshare.7654346.v1
title: Additional file 11: of Comparison of splenocyte microRNA expression profiles of pigs during acute and chronic toxoplasmosis

description: Table S8. DEMs induced by T. gondii at 50 DPI regulating the gene expression in BCR signaling pathway. (XLSX 10 kb)
DOI: 10.6084/m9.figshare.8092469.v1
title: Preservation and evaluation of spiced chayote juice using hurdle technology

description: Abstract Chayote (Sechium edule) is a perennial climbing plant, belonging to the Cucurbitaceae family and is neglected or underutilized as a food or as a raw material in the food industry because of its bland taste. This bland taste can be overcome by blending with a suitable substrate such as sugarcane juice along with natural flavouring. However, this blending represents a preservation problem for the spiced juice, since both chayote juice and sugarcane juice are prone to microbial attack. Therefore, an attempt was made in the present study to preserve the spiced chayote juice by employing different hurdles i.e. pasteurization temperature (70 °C and 80 °C) and pasteurization time (10 and 20 min) followed by the addition of different concentrations of potassium metabisulphite (KMS) (200, 300 and 400 ppm). The samples so prepared were filled into glass bottles and stored under refrigeration for forty-five days. As the storage period proceeded there were significant decreases in pH, total protein content, total phenolic compounds, antioxidant activity, reducing power, metal chelation, tannin content, ascorbic acid content and overall acceptability, whereas there were significant increases in TSS (total soluble solids), titratable acidity, reducing sugars, total sugar, TPC (total plate count) and MIC (minimum inhibitory concentration). A cluster analysis of the data revealed that the pasteurization temperature exerted the most significant effect on the physicochemical and sensory characteristics of the spiced chayote juice as compared to the pasteurization time and KMS concentration, which failed to fall into the separate and respective clusters. In a nutshell, it was concluded that spiced chayote juice can be successfully preserved using hurdle technology (pasteurizing at 70 °C for 10 min followed by the addition of 400ppm KMS).
DOI: 10.14272/rjhhgqmrvyaagu-uhfffaoysa-n.1
title: ethyl 3-(4-(acetoxymethyl)-1H-1,2,3-triazol-1-yl)-1H-pyrazole-4-carboxylate
title: InChI=1S/C11H13N5O4/c1-3-19-11(18)9-4-12-14-10(9)16-5-8(13-15-16)6-20-7(2)17/h4-5H,3,6H2,1-2H3,(H,12,14)

description: This is a physical chemical entity[CHEBI_24431] associated with a molecule[CHEBI_25367].
 The molecule[CHEBI_25367] can be described by the following structural desciptors[cheminf_000085]:
 InChI descriptor[cheminf_000113]: InChI=1S/C11H13N5O4/c1-3-19-11(18)9-4-12-14-10(9)16-5-8(13-15-16)6-20-7(2)17/h4-5H,3,6H2,1-2H3,(H,12,14), and canonical SMILES descriptor[cheminf_000007]: CCOC(=O)c1c[nH]nc1n1nnc(c1)COC(=O)C, and by the IUPAC name[cheminf_000107]: .
 
 The physical chemical entity[CHEBI_24431] has a component solvent[CHEBI_46787] which is described by the canonical SMILES descriptor[cheminf_000007]:
 
 The physical chemical entity[CHEBI_24431] has the following Sample ID as registered in the research data repository chemotion (www.chemotion-repository.net, https://doi.org/10.25504/FAIRsharing.iagXcR): CRS-22850

 The physical chemical entity[CHEBI_24431] can be described by the physical descriptors [CHEMINF_000025]:
 Melting point descriptor[CHEMINF_000256]: 126.1 - 139.8 (°C)
 Boiling point descriptor[CHEMINF_000257]: 
 Refractive index descriptor[CHEMINF_000253]:

 The physical chemical entity[CHEBI_24431] can be further described by the following assays[OBI:0000070][CHMO:0001133]:
 
 CHMO:0000593 | 1H nuclear magnetic resonance spectroscopy (1H NMR)
 
 CHMO:0000595 | 13C nuclear magnetic resonance spectroscopy (13C NMR)
 
 CHMO:0000596 | distortionless enhancement with polarization transfer (DEPT)
 
 CHMO:0000596 | distortionless enhancement with polarization transfer (DEPT)
 
 CHMO:0000604 | heteronuclear single quantum coherence (HSQC)
 
 CHMO:0000601 | heteronuclear multiple bond coherence (HMBC)
 
 CHMO:0000470 | mass spectrometry (MS)
 
 CHMO:0000630 | infrared absorption spectroscopy (IR)
 
 The physical chemical entity[CHEBI_24431] was deposited to the Molecule Archive of the Karlsruhe Insitute of Technology (KIT) with the following Sample ID: 

 Used ontologies:
 CHEBI - Chemical Entities of Biological Interest
 CHEMINF - chemical information ontology (information entities about chemical entities)
 CHMO - Chemical Methods Ontology
 OBI - Ontology for Biomedical Investigations
DOI: 10.6084/m9.figshare.14393706
title: Sex specific effect of gut microbiota on the risk of psychiatric disorders: A Mendelian randomisation study and PRS analysis using UK Biobank cohort

description: The relationships between gut microbiota and brain-related diseases/traits remains not fully understood. A two-stage study was performed to investigate the relationships between gut microbiota and brain-related diseases/traits, and evaluate the potential sex specific effects of gut microbiota. In discovery stage, we systematically scanned the relationships between 515 brain-related diseases/traits and gut microbiota through two-sample Mendelian randomisation analysis. Using ∼500,000 individuals derived from the UK Biobank, polygenetic risk scoring (PRS) analysis was performed to validate the associations detected in discovery stage. To evaluate the potential sex-specific effect of gut microbiota on brain-related disorders, PRS analysis was conducted in female and male, respectively. After systematically scanning diseases or traits, 41 of the 515 brain-related diseases/traits were identified to be associated with gut microbiota, such as Neuroticism score (<i>P<sub>2-MR</sub></i> = 0.0018), worrier/anxious feelings (<i>P<sub>2-MR</sub></i> = 0.0013), Suffer from ‘nerves’ (<i>P<sub>2-MR</sub></i> = 0.0062) and Nervous feelings (<i>P<sub>2-MR</sub></i> = 0.0158). 5 of 41 brain-related diseases or traits were successfully validated in UK Biobank, such as Neuroticism score (<i>P<sub>UK</sub></i> = 0.0024, <i>P<sub>UK-female</sub></i> = 0.0063, <i>P<sub>UK-male</sub></i> = 0.1142), Nervous feelings (<i>P<sub>UK</sub></i> = 0.0043, <i>P<sub>UK-female</sub></i> = 0.0115, <i>P<sub>UK-male</sub> = </i>0.1670) and Worrier/anxious feelings (<i>P<sub>UK</sub></i> = 0.0166, <i>P<sub>UK-female</sub></i> = 0.0196, <i>P<sub>UK-male</sub> = </i>0.2930). Our results suggest that gut microbiota contributed more to brain-related diseases or traits in females than in males.Key pointsA two-stage study was performed to investigate the relationships between gut microbiota and brain-related diseases/traits.Using the individuals derived from the UK Biobank, polygenetic risk scoring analysis was performed to validate the associations detected in the discovery stage.Our results suggest that gut microbiota contributed more to brain-related diseases or traits in females than in males. A two-stage study was performed to investigate the relationships between gut microbiota and brain-related diseases/traits. Using the individuals derived from the UK Biobank, polygenetic risk scoring analysis was performed to validate the associations detected in the discovery stage. Our results suggest that gut microbiota contributed more to brain-related diseases or traits in females than in males.
DOI: 10.6084/m9.figshare.8092034.v1
title: Integrated Guidance and Control of Multiple Interceptor Missiles Based on Improved Distributed Cooperative Control Strategy

description: ABSTRACT In this study, an improved cooperative integrated guidance and control (IGC) design method is proposed based on distributed networks to address the guidance and control problem of multiple interceptor missiles. An IGC model for a leading interceptor is constructed based on the relative kinematic relations between missiles and a target and the kinematic equations of the missiles in a pitch channel. The unknown disturbances of the model are estimated using a finite-time disturbance observer (FTDO). Then, the control algorithm for the leading interceptor is designed according to the disturbance estimation and nonsingular fast dynamic surface sliding mode control (SMC). To enhance the rate of convergence of the cooperative control commands for the interceptors, an improved cooperative control strategy is proposed based on the leader-follower distributed network. Consequently, the two velocity components of the interceptor in the pitch channel can be obtained, which are subsequently converted to the total velocity and flight path angle commands of the interceptor using kinematic relations. The control algorithm for the following interceptor is similarly designed using an FTDO and dynamic surface SMC. The effectiveness of the improved distributed cooperative control strategy for multiple interceptors is validated through simulations.
DOI: 10.6084/m9.figshare.20145653
title: Additional file 12 of CircRNAs in Xiang pig ovaries among diestrus and estrus stages

description: Additional file 12. Table S12. Interaction of DEC-miRNA-DEG.
DOI: 10.6084/m9.figshare.20145659
title: Additional file 13 of CircRNAs in Xiang pig ovaries among diestrus and estrus stages

description: Additional file 13. Table S13. Interaction of DEC-miRNA-DEG associated with reproduction pathways.
DOI: 10.6084/m9.figshare.8092760
title: Prophylactic central neck dissection and local recurrence in papillary thyroid microcarcinoma: a meta-analysis,

description: Abstract Introduction: For papillary thyroid microcarcinoma patients, the reported incidence of lymph node metastasis is as high as 40%, and these occur mainly in the central compartment of the neck. Because these metastases are difficult to detect using ultrasonography preoperatively, some authors advocate routine central neck dissection in papillary thyroid microcarcinoma patients at the time of initial thyroidectomy. Objective: To evaluate whether prophylactic central neck dissection can decrease the local recurrence rate of papillary thyroid microcarcinoma after thyroidectomy. Methods: The publicly available literature published from January 1990 to December 2017 concerning thyroidectomy plus prophylactic central neck dissection versus thyroidectomy for papillary thyroid microcarcinoma was retrieved by searching the national and international online databases. A meta-analysis was performed after the data extraction process. Results: Four studies were finally included with a total of 727 patients, of whom, 366 cases underwent thyroidectomy plus prophylactic central neck dissection and 361 cases received thyroidectomy only. As shown by the meta-analysis results, the recurrence rates in cases of thyroidectomy plus prophylactic central neck dissection were approximately 1.91% and were significantly lower than those with thyroidectomy only (OR = 0.24, 95% CI [0.10, 0.56], p = 0.0009). Conclusion: For patients with papillary thyroid microcarcinoma, thyroidectomy plus prophylactic central neck dissection is a safe and efficient procedure and it results in lower recurrence rate. Since the evidences are of low quality (non-randomized studies), further randomized trials are needed.