DOI: 10.5061/dryad.k66jn2s
title: Data from: The alternative regenerative strategy of bearded dragon unveils the key processes underlying vertebrate tooth renewal

description: Deep understanding of lifelong tooth replacement is hampered by the lack
 of polyphyodonty or oral dentition in conventional models. Here, we show
 that the bearded dragon, one of the rare vertebrate species with both
 polyphyodont and monophyodont teeth, constitutes a key model for filling
 this gap, allowing direct comparison of extreme dentition types. Our
 developmental and high-throughput transcriptomic data of microdissected
 dental cells unveils the critical importance of successional dental lamina
 patterning, in addition to maintenance, for vertebrate tooth renewal. This
 patterning process happens at various levels, including directional growth
 but also gene expression levels, dynamics, and regionalization, and
 involves a large number of yet uncharacterized dental genes. Furthermore,
 the alternative renewal mechanism of bearded dragon dentition, with dual
 location of slow-cycling cells, demonstrates the importance of cell
 migration and functional specialization of putative epithelial
 stem/progenitor niches in tissue regeneration, while expanding the
 diversity of dental replacement strategies in vertebrates.
description: Pogona vitticeps tooth
 transcriptomicsPaired-end sequencing
 reads (Illumina technology) of dental mesenchyme tissues of acrodont teeth
 from Pogona vitticeps lizard, biological replicate 2PVADME2.tar.gzPogona vitticeps tooth transcriptomicsPaired-end sequencing reads (Illumina technology) of dental mesenchyme tissues of acrodont teeth from Pogona vitticeps lizard, biological replicate 3PVADME3.tar.gzPogona vitticeps tooth transcriptomicsPaired-end sequencing reads (Illumina technology) of dental mesenchyme tissues of acrodont teeth from Pogona vitticeps lizard, biological replicate 1PVADME1.tar.gzPogona vitticeps tooth transcriptomicsPaired-end sequencing reads (Illumina technology) of successional dental lamina tissues of acrodont teeth from Pogona vitticeps lizard, biological replicate 1PVASDL1.tar.gzPogona vitticeps tooth transcriptomicsPaired-end sequencing reads (Illumina technology) of successional dental lamina tissues of acrodont teeth from Pogona vitticeps lizard, biological replicate 2PVASDL2.tar.gzPogona vitticeps tooth transcriptomicsPaired-end sequencing reads (Illumina technology) of successional dental lamina tissues of acrodont teeth from Pogona vitticeps lizard, biological replicate 3PVASDL3.tar.gzPogona vitticeps tooth transcriptomicsPaired-end sequencing reads (Illumina technology) of dental mesenchyme tissues of pleurodont teeth from Pogona vitticeps lizard, biological replicate 1PVPDME1.tar.gzPogona vitticeps tooth transcriptomicsPaired-end sequencing reads (Illumina technology) of dental mesenchyme tissues of pleurodont teeth from Pogona vitticeps lizard, biological replicate 2PVPDME2.tar.gzPogona vitticeps tooth transcriptomicsPaired-end sequencing reads (Illumina technology) of dental mesenchyme tissues of pleurodont teeth from Pogona vitticeps lizard, biological replicate 3PVPDME3.tar.gzPogona vitticeps tooth transcriptomicsPaired-end sequencing reads (Illumina technology) of successional dental lamina tissues of pleurodont teeth from Pogona vitticeps lizard, biological replicate 1PVPSDL1.tar.gzPogona vitticeps tooth transcriptomicsPaired-end sequencing reads (Illumina technology) of successional dental lamina tissues of pleurodont teeth from Pogona vitticeps lizard, biological replicate 2PVPSDL2.tar.gzPogona vitticeps tooth transcriptomicsPaired-end sequencing reads (Illumina technology) of successional dental lamina tissues of pleurodont teeth from Pogona vitticeps lizard, biological replicate 3PVPSDL3.tar.gz