cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.21670053.v1
title: Effects of the epiretinal membrane on the outcomes of intravitreal dexamethasone implantation for macular edema secondary to branch retinal vein occlusion

description: ABSTRACT Purpose: To investigate the effects of epiretinal membrane formation on the clinical outcomes of intravitreal dexamethasone implantation for macular edema secondary to branch retinal vein occlusion. Methods: This retrospective interventional case series includes the treatment of naive patients with macular edema secondary to non-ischemic branch retinal vein occlusion who underwent intravitreal dexamethasone implantation. The patients were divided into two groups as follows: Group 1 (n=25), comprised of patients with macular edema secondary to branch retinal vein occlusion without epiretinal membrane, and Group 2 (n=16), comprised of patients with macular edema secondary to branch retinal vein occlusion with an epiretinal membrane. Corrected visual acuity, central macular thickness, and central macular volume values were measured before and after treatment. The clinical outcomes of the groups were compared. Results: Mean age and male-to-female ratio were similar between the two groups (p&gt;0.05, for both). The baseline and final corrected visual acuity values, central macular thickness, and central macular volumes of the groups were similar (p&gt;0.05, for all). All the parameters were significantly improved after intravitreal dexamethasone implantation treatment (p&lt;0.001, for all). The changes in central macular thickness and volume were also similar (p&gt;0.05, for both). The mean number of intravitreal dexamethasone implantations was 2.1 ± 1.0 (range, 1-4) in Group 1 and 3.0 ± 1.2 (range, 1-5) in Group 2 (p=0.043). Conclusion: Epiretinal membrane formation had no effects on the baseline and final clinical parameters, including corrected visual acuity and central macular thickness and volume. The only parameter affected by the presence of epiretinal membrane formation is the number of intravitreal dexamethasone implantations, a greater number of which is needed for macular edema secondary to branch retinal vein occlusion with an epiretinal membrane.
DOI: 10.6084/m9.figshare.21670054
title: How can residency programs be evaluated based on the Progress Test?

description: Abstract: Introduction: Although specialized knowledge is a fundamental element for qualified medical practice, in most specialties, there is no unified cognitive assessment of resident physicians, and it is impossible to verify the knowledge gained during training in Medical Residency Programs (MRPs). The Progress Test (PT) provides an opportunity to evaluate MRPs based on the performance of the residents. In 2018, Febrasgo applied the Resident Progress Test in Gynecology and Obstetrics (TPI-GO) throughout Brazil. Experience report: This descriptive study refers to the longitudinal follow-up of residents who started participating in the TPI-GO in 2018 as R1 (n=497) and completed their participation in 2020 as R3 (n = 314). The performance of these residents in the TPI-GO served as a basis for analyzing the profile of 32 MRPs located in the South (28.1%), Southeast (68.8%), and Central-West (3.1%) regions of Brazil, with five different identified PRM profiles in relation to the performance of beginner residents, differences in performance between R3 and R1 and the performance of residency graduates. Discussion: In Brazil, comprehensive and unified assessments of knowledge are not offered to resident physicians in most specialties, and consequently, it is not yet possible to incorporate this information into the assessment of MRPs. In the model presented here, the performance of residents in the PT enables one to make inferences about the selection process, the knowledge added by the MRP throughout the training, and the level of knowledge of the graduates, being recognized as qualified MRPs (type 1) and MRPs that need improvement (types 2, 3, 4 and 5). Conclusion: The PT offers an opportunity to evaluate MRPs based on the performance of their residents. Through the model presented here, it is possible to obtain information to support institutional decisions that promote improvements in MRPs and their training process in the specialty.
DOI: 10.6084/m9.figshare.21670054.v1
title: How can residency programs be evaluated based on the Progress Test?

description: Abstract: Introduction: Although specialized knowledge is a fundamental element for qualified medical practice, in most specialties, there is no unified cognitive assessment of resident physicians, and it is impossible to verify the knowledge gained during training in Medical Residency Programs (MRPs). The Progress Test (PT) provides an opportunity to evaluate MRPs based on the performance of the residents. In 2018, Febrasgo applied the Resident Progress Test in Gynecology and Obstetrics (TPI-GO) throughout Brazil. Experience report: This descriptive study refers to the longitudinal follow-up of residents who started participating in the TPI-GO in 2018 as R1 (n=497) and completed their participation in 2020 as R3 (n = 314). The performance of these residents in the TPI-GO served as a basis for analyzing the profile of 32 MRPs located in the South (28.1%), Southeast (68.8%), and Central-West (3.1%) regions of Brazil, with five different identified PRM profiles in relation to the performance of beginner residents, differences in performance between R3 and R1 and the performance of residency graduates. Discussion: In Brazil, comprehensive and unified assessments of knowledge are not offered to resident physicians in most specialties, and consequently, it is not yet possible to incorporate this information into the assessment of MRPs. In the model presented here, the performance of residents in the PT enables one to make inferences about the selection process, the knowledge added by the MRP throughout the training, and the level of knowledge of the graduates, being recognized as qualified MRPs (type 1) and MRPs that need improvement (types 2, 3, 4 and 5). Conclusion: The PT offers an opportunity to evaluate MRPs based on the performance of their residents. Through the model presented here, it is possible to obtain information to support institutional decisions that promote improvements in MRPs and their training process in the specialty.
DOI: 10.6084/m9.figshare.21670057
title: Progress Test and curricular change: paths followed by the University of Brasília Medical School

description: Abstract: Introduction: The Progress Test (TP) is an assessment instrument applied annually and coordinated by the Brazilian Association of Medical Education (ABEM). The UnB School of Medicine has participated in the TP-CO since 2013 and uses the data from the assessment for internal diagnosis and discussions about medical education. Objective: describe the results obtained by students in the TP and analyze possible relationships between changes in the PPC and student performance. Method: This is an analytical cross-sectional study, based on the results obtained by the students of the course compared to the universe of institutions in the TP-CO consortium between 2013 and 2021. In this period, students enrolled in two curricular matrices sat the test: old curriculum (AC) and new curriculum (CN). In order to verify the evolution of the average score of UnB in each period compared to the average score of the consortium, the ratio test was applied to the differences in each pair of scores of UnB and consortium, in each year of the historical series and period of the students evaluated. Results: Between the years 2013 and 2015, when the CA was in effect, no statistically significant differences were observed in the averages between the UnB students of all course years compared to the TP-CO Consortium. The same behavior was verified between 2016 and 2018, a transition period composed of CA and CN matrix students. However, between 2019 and 2021, when the new curricular matrix was in effect, statistically significant differences were observed between the UnB and consortium students. Conclusion: The TP gives insight into the performance of the school and identifies gaps that generate reflections in the search for excellence in medical education. With the experience presented it was possible to identify the paths taken by the UnB course throughout its participation in the consortium, considering the curricular changes.
DOI: 10.6084/m9.figshare.21670057.v1
title: Progress Test and curricular change: paths followed by the University of Brasília Medical School

description: Abstract: Introduction: The Progress Test (TP) is an assessment instrument applied annually and coordinated by the Brazilian Association of Medical Education (ABEM). The UnB School of Medicine has participated in the TP-CO since 2013 and uses the data from the assessment for internal diagnosis and discussions about medical education. Objective: describe the results obtained by students in the TP and analyze possible relationships between changes in the PPC and student performance. Method: This is an analytical cross-sectional study, based on the results obtained by the students of the course compared to the universe of institutions in the TP-CO consortium between 2013 and 2021. In this period, students enrolled in two curricular matrices sat the test: old curriculum (AC) and new curriculum (CN). In order to verify the evolution of the average score of UnB in each period compared to the average score of the consortium, the ratio test was applied to the differences in each pair of scores of UnB and consortium, in each year of the historical series and period of the students evaluated. Results: Between the years 2013 and 2015, when the CA was in effect, no statistically significant differences were observed in the averages between the UnB students of all course years compared to the TP-CO Consortium. The same behavior was verified between 2016 and 2018, a transition period composed of CA and CN matrix students. However, between 2019 and 2021, when the new curricular matrix was in effect, statistically significant differences were observed between the UnB and consortium students. Conclusion: The TP gives insight into the performance of the school and identifies gaps that generate reflections in the search for excellence in medical education. With the experience presented it was possible to identify the paths taken by the UnB course throughout its participation in the consortium, considering the curricular changes.
DOI: 10.6084/m9.figshare.21670059
title: Anti-Acanthamoeba castellanii activity of alkaloid-enriched extracts and lycorine from the Amaryllidaceae species

description: Abstract Free-living amoebae of the genus Acanthamoeba are the causative agents of granulomatous encephalitis and keratitis, severe human infections. Bioactive compounds from plants are recognized as an alternative source for the development of new drugs. The Amaryllidaceae is a botanical family able to synthesize a very specific and consistent group of biologically active isoquinoline-like alkaloids. The alkaloidal fractions from the Brazilian species Hippeastrum canastrense, H. diniz-cruziae, H. puniceum, and Crinum x amabile, along with the alkaloid lycorine, were investigated against Acanthamoeba castellanii. The in vitro assays were performed with distinct concentrations of lycorine and alkaloidal fractions, while the cell viability was evaluated by the MTT method upon MDCK cells. Chlorhexidine 0.02% was used as the positive control. The effect of alkaloid fractions was concentration dependent, and 2000 μg mL-1 of H. canastrense and H. diniz-cruziae provided a 100% inhibition. At concentrations of 250, 500, and 1000 μg mL-1, the H. diniz-cruziae alkaloidal fraction showed the lowest cytotoxic effect (5%-7%) and remarkable anti-amoebic activity, demonstrating values of IC50 285.61 μg mL-1, low cytotoxicity (5%-7%), and selectivity index (7.0). Taken together, the results are indicative of the great potential that the alkaloids from H. diniz-cruziae have as new candidates for anti-amoebicidal compounds.
DOI: 10.6084/m9.figshare.21670059.v1
title: Anti-Acanthamoeba castellanii activity of alkaloid-enriched extracts and lycorine from the Amaryllidaceae species

description: Abstract Free-living amoebae of the genus Acanthamoeba are the causative agents of granulomatous encephalitis and keratitis, severe human infections. Bioactive compounds from plants are recognized as an alternative source for the development of new drugs. The Amaryllidaceae is a botanical family able to synthesize a very specific and consistent group of biologically active isoquinoline-like alkaloids. The alkaloidal fractions from the Brazilian species Hippeastrum canastrense, H. diniz-cruziae, H. puniceum, and Crinum x amabile, along with the alkaloid lycorine, were investigated against Acanthamoeba castellanii. The in vitro assays were performed with distinct concentrations of lycorine and alkaloidal fractions, while the cell viability was evaluated by the MTT method upon MDCK cells. Chlorhexidine 0.02% was used as the positive control. The effect of alkaloid fractions was concentration dependent, and 2000 μg mL-1 of H. canastrense and H. diniz-cruziae provided a 100% inhibition. At concentrations of 250, 500, and 1000 μg mL-1, the H. diniz-cruziae alkaloidal fraction showed the lowest cytotoxic effect (5%-7%) and remarkable anti-amoebic activity, demonstrating values of IC50 285.61 μg mL-1, low cytotoxicity (5%-7%), and selectivity index (7.0). Taken together, the results are indicative of the great potential that the alkaloids from H. diniz-cruziae have as new candidates for anti-amoebicidal compounds.
DOI: 10.6084/m9.figshare.21670060
title: Organizational knowledge retention: international literature review

description: ABSTRACT The aim of this work was to select an international knowledge fragment about the organizational knowledge retention theme, and to identify the characteristics of these studies. Methodologically, this research is guided by a constructivist perspective, with a qualitative-quantitative approach and with an exploratory and descriptive objectives. The Knowledge Development Process - Construtivist (Proknow-C) was used to select a Bibliographic Portfolio in line with the research theme and for bibliometric analysis. Among the main results, the co-authorship network demonstrated little relationship between the 48 researchers of the theme. However, the citation network showed constant and historically evolutionary referencing between articles. Most of the researches aimed to identify or present aspects of organizational knowledge retention. The main related topics were: knowledge management, human resources management and organizational structure. The most used dimensions were: knowledge retention, knowledge loss, information systems, organizational memory, turnover, retirement and knowledge transfer. United States of America, Australia and Canada stood out as host countries of organizations where empirical researches took place and also as headquarters of research institutions. The results showed the dynamics and characteristics of researches on organizational knowledge retention, in the sample used, and provide guidance for the evolution of the theme.
DOI: 10.6084/m9.figshare.21670060.v1
title: Organizational knowledge retention: international literature review

description: ABSTRACT The aim of this work was to select an international knowledge fragment about the organizational knowledge retention theme, and to identify the characteristics of these studies. Methodologically, this research is guided by a constructivist perspective, with a qualitative-quantitative approach and with an exploratory and descriptive objectives. The Knowledge Development Process - Construtivist (Proknow-C) was used to select a Bibliographic Portfolio in line with the research theme and for bibliometric analysis. Among the main results, the co-authorship network demonstrated little relationship between the 48 researchers of the theme. However, the citation network showed constant and historically evolutionary referencing between articles. Most of the researches aimed to identify or present aspects of organizational knowledge retention. The main related topics were: knowledge management, human resources management and organizational structure. The most used dimensions were: knowledge retention, knowledge loss, information systems, organizational memory, turnover, retirement and knowledge transfer. United States of America, Australia and Canada stood out as host countries of organizations where empirical researches took place and also as headquarters of research institutions. The results showed the dynamics and characteristics of researches on organizational knowledge retention, in the sample used, and provide guidance for the evolution of the theme.
DOI: 10.34740/kaggle/dsv/4641729
title: Longest driving range electric cars(2022)
DOI: 10.6084/m9.figshare.21670063
title: Physico-chemical characteristics of the oil from macauba kernels stored after drying at different temperatures

description: ABSTRACT Studies of post-harvest storage and drying in macauba fruit (Acrocomia aculeata (Jacq.) Lodd. Mart) are still in the early stages. The aim of this work was to investigate the effect of drying on the quality of macauba kernel oil during storage. Drying was carried out under three different air temperatures: 40°C, 50°C and 60°C. Four replications were used for each temperature. After drying, the kernels were stored for 0, 60, 120, 240 and 360 days, and the following physico-chemical analyses were carried out for each period: kernel oil content, acidity index, oxidative stability, water activity and oil colour. An increase in storage time resulted in an increase in the acidity index and a reduction in the oxidative stability of the oil in all treatments. The mean value for water activity in the oil ranged from 0.56 to 0.68. The mean values of the L* and b* coordinates did not differ from the control, except for the storage times of 0 and 60 days. There was a difference in the a* coordinate between the drying processes when compared to the control. No significant differences were seen for oil content. It was concluded that drying can be efficient tool in controlling the quality of kernel oil during storage.
DOI: 10.6084/m9.figshare.21670063.v1
title: Physico-chemical characteristics of the oil from macauba kernels stored after drying at different temperatures

description: ABSTRACT Studies of post-harvest storage and drying in macauba fruit (Acrocomia aculeata (Jacq.) Lodd. Mart) are still in the early stages. The aim of this work was to investigate the effect of drying on the quality of macauba kernel oil during storage. Drying was carried out under three different air temperatures: 40°C, 50°C and 60°C. Four replications were used for each temperature. After drying, the kernels were stored for 0, 60, 120, 240 and 360 days, and the following physico-chemical analyses were carried out for each period: kernel oil content, acidity index, oxidative stability, water activity and oil colour. An increase in storage time resulted in an increase in the acidity index and a reduction in the oxidative stability of the oil in all treatments. The mean value for water activity in the oil ranged from 0.56 to 0.68. The mean values of the L* and b* coordinates did not differ from the control, except for the storage times of 0 and 60 days. There was a difference in the a* coordinate between the drying processes when compared to the control. No significant differences were seen for oil content. It was concluded that drying can be efficient tool in controlling the quality of kernel oil during storage.
DOI: 10.6084/m9.figshare.21670066.v1
title: Numerical and experimental investigation of the ballistic performance of the armor structure with in-layer deflector against bullets

description: Abstract This is a study to investigate ballistics performance of armor structures with in-layer deflector against projectiles. For this purpose, the armor structure, which consists of a v-cross section sheet metal array covered with aluminum and steel plates, has been designed and optimized. Firstly, numerical simulations were studied using the finite-element method (FEM). The ANSYS LS-DYNA FE software is used for the ballistic analysis. The Johnson-Cook constitutive equation and damage model were used to model the behavior of metal armors under impact in the ballistic simulations. In the next step, experimental studies were carried out. Penetration depths were measured; including the magnitude of plate bending in front of the target plate and bulging behind it. Comparisons between the results of the finite element analysis (FEA) and the tests reveal that a bullet with a velocity of 868 m/s penetrated the target, but the target could not be penetrated at a firing speed of 631 m/s Furthermore the experimental and numerical results were in good agreement.
DOI: 10.6084/m9.figshare.21670066
title: Numerical and experimental investigation of the ballistic performance of the armor structure with in-layer deflector against bullets

description: Abstract This is a study to investigate ballistics performance of armor structures with in-layer deflector against projectiles. For this purpose, the armor structure, which consists of a v-cross section sheet metal array covered with aluminum and steel plates, has been designed and optimized. Firstly, numerical simulations were studied using the finite-element method (FEM). The ANSYS LS-DYNA FE software is used for the ballistic analysis. The Johnson-Cook constitutive equation and damage model were used to model the behavior of metal armors under impact in the ballistic simulations. In the next step, experimental studies were carried out. Penetration depths were measured; including the magnitude of plate bending in front of the target plate and bulging behind it. Comparisons between the results of the finite element analysis (FEA) and the tests reveal that a bullet with a velocity of 868 m/s penetrated the target, but the target could not be penetrated at a firing speed of 631 m/s Furthermore the experimental and numerical results were in good agreement.
DOI: 10.6084/m9.figshare.21670069
title: Myelin oligodendrocyte glycoprotein antibody-associated optic neuritis: an update

description: ABSTRACT Myelin oligodendrocyte glycoprotein-immunoglobulin G (IgG)-associated optic neuritis has been established as a new entity of immune-mediated optic neuropathy. Patients usually present with recurrent optic neuritis, often bilaterally with initially severe vision loss and optic disc edema. However, in contrast to aquaporin 4-IgG-seropositive neuromyelitis optica spectrum disorder, visual recovery tends to be more favorable, with good response to steroid treatment. Another important differential diagnosis of myelin oligodendrocyte glycoprotein-IgG--associated optic neuritis is multiple sclerosis. Close monitoring for signs of relapse and long-term immunosuppression may be considered to maintain optimal visual function. The diagnosis can be made on the basis of the presence of a specific, usually serological, antibody against myelin oligodendrocyte glycoprotein (IgG; cell-based assay), and a demyelinating event (optic neuritis, myelitis, brainstem syndrome, or cortical lesions with seizures). The clinical spectrum of this newly recognized inflammatory demyelinating disease is expanding rapidly. We briefly review the epidemiological characteristics, clinical manifestations, diagnostic considerations, and treatment options of myelin oligodendrocyte glycoprotein-IgG-associated optic neuritis.