cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.6031892.v1
title: Supplementary Material for: Activation of Adenylyl Cyclase Causes Stimulation of Adenosine Receptors

description: <b><i>Background/Aims:</i></b> Signaling of G<sub>s</sub> protein-coupled receptors (GsPCRs) is accomplished by stimulation of adenylyl cyclase, causing an increase of the intracellular cAMP concentration, activation of the intracellular cAMP effectors protein kinase A (PKA) and Epac, and an efflux of cAMP, the function of which is still unclear. <b><i>Methods:</i></b> Activation of adenylyl cyclase by GsPCR agonists or cholera toxin was monitored by measurement of the intracellular cAMP concentration by ELISA, anti-phospho-PKA substrate motif phosphorylation by immunoblotting, and an Epac-FRET assay in the presence and absence of adenosine receptor antagonists or ecto-nucleotide phosphodiesterase/pyrophosphatase2 (eNPP2) inhibitors. The production of AMP from cAMP by recombinant eNPP2 was measured by HPLC. Extracellular adenosine was determined by LC-MS/MS, extracellular ATP by luciferase and LC-MS/MS. The expression of eNPP isoenzymes 1-3 was examined by RT-PCR. The expression of multidrug resistance protein 4 was suppressed by siRNA. <b><i>Results:</i></b> Here we show that the activation of GsPCRs and the GsPCRs-independent activation of G<sub>s</sub> proteins and adenylyl cyclase by cholera toxin induce stimulation of cell surface adenosine receptors (A<sub>2A</sub> or A<sub>2B</sub> adenosine receptors). In PC12 cells stimulation of adenylyl cyclase by GsPCR or cholera toxin caused activation of A<sub>2A</sub> adenosine receptors by an autocrine signaling pathway involving cAMP efflux through multidrug resistance protein 4 and hydrolysis of released cAMP to AMP by eNPP2. In contrast, in PC3 cells cholera toxin- and GsPCR-induced stimulation of adenylyl cyclase resulted in the activation of A<sub>2B</sub> adenosine receptors. <b><i>Conclusion:</i></b> Our findings show that stimulation of adenylyl cyclase causes a remarkable activation of cell surface adenosine receptors.
DOI: 10.6084/m9.figshare.6031850
title: Supplementary Material for: Early and One-Year Outcomes of Acute Stroke in the Industrial Region of Poland During the Decade 2006–2015: The Silesian Stroke Registry

description: <b><i>Background:</i></b> Poland, classified as a high-income country, is still considered to have a high cardiovascular risk population. During the last decade, the standards of care in acute stroke (AS) had markedly improved; thus, we aimed to assess whether and how it translated into early and late outcomes. <b><i>Methods:</i></b> Silesian Stroke Registry was created from the administrative database of the public, obligatory, health ­insurer in Poland. The AS cases were selected based on primary diagnosis coded in ICD-10 as I60-I64 for years 2006–2015 (<i>n</i> = 120,844). Index hospitalization together with data on re-hospitalizations, procedures, ambulatory visits, rehabilitation and all-cause deaths in a 1-year follow-up were analyzed. <b><i>Results:</i></b> The rates of admissions per 100,000 adult population varied between 41–47 for haemorrhagic and 257–275 for ischaemic stroke with substantial decrease in almost all age groups except for the oldest patients. In ischaemic stroke, thrombolytic therapy raised from 0 to 8.8% in 2015, along with significant trends of decreasing 30-day (from 20 to 16%) and 12-month (from 35 to 31%) case fatality. In haemorrhagic stroke, case fatality had not changed. After ischaemic stroke, 12-month readmissions due to AS declined from 11–12% in 2006–2009 to 9% in 2010–2014. The percentage of patients benefiting from rehabilitation increased from 24 to 32%. <b><i>Conclusions:</i></b> In a large population of industrial province, we showed recent, positive trends in AS admissions, treatment and 1-year outcomes. Development of stroke unit networks and increase in thrombolytic treatment were at least in part responsible for survival improvement and reduction of recurrence of AS. However, case-fatality and stroke recurrence remain high compared to those of other developed countries.
DOI: 10.6084/m9.figshare.6031850.v1
title: Supplementary Material for: Early and One-Year Outcomes of Acute Stroke in the Industrial Region of Poland During the Decade 2006–2015: The Silesian Stroke Registry

description: <b><i>Background:</i></b> Poland, classified as a high-income country, is still considered to have a high cardiovascular risk population. During the last decade, the standards of care in acute stroke (AS) had markedly improved; thus, we aimed to assess whether and how it translated into early and late outcomes. <b><i>Methods:</i></b> Silesian Stroke Registry was created from the administrative database of the public, obligatory, health ­insurer in Poland. The AS cases were selected based on primary diagnosis coded in ICD-10 as I60-I64 for years 2006–2015 (<i>n</i> = 120,844). Index hospitalization together with data on re-hospitalizations, procedures, ambulatory visits, rehabilitation and all-cause deaths in a 1-year follow-up were analyzed. <b><i>Results:</i></b> The rates of admissions per 100,000 adult population varied between 41–47 for haemorrhagic and 257–275 for ischaemic stroke with substantial decrease in almost all age groups except for the oldest patients. In ischaemic stroke, thrombolytic therapy raised from 0 to 8.8% in 2015, along with significant trends of decreasing 30-day (from 20 to 16%) and 12-month (from 35 to 31%) case fatality. In haemorrhagic stroke, case fatality had not changed. After ischaemic stroke, 12-month readmissions due to AS declined from 11–12% in 2006–2009 to 9% in 2010–2014. The percentage of patients benefiting from rehabilitation increased from 24 to 32%. <b><i>Conclusions:</i></b> In a large population of industrial province, we showed recent, positive trends in AS admissions, treatment and 1-year outcomes. Development of stroke unit networks and increase in thrombolytic treatment were at least in part responsible for survival improvement and reduction of recurrence of AS. However, case-fatality and stroke recurrence remain high compared to those of other developed countries.
DOI: 10.6084/m9.figshare.6031835
title: Put in the spotlight or largely ignored? Emphasis on the <i>Spitzenkandidaten</i> by political parties in their online campaigns for European elections

description: This article contributes to the debate about the introduction of the <i>Spitzenkandidaten</i> (lead candidates) in the 2014 European Parliament (EP) election. Focusing on parties’ efforts to make the candidates visible to voters, we argue that the multi-level character of these elections creates large differences concerning individual parties’ incentives to promote the <i>Spitzenkandidaten</i> in their campaigns. Analysing a novel dataset of campaign communication on Facebook, we find that only a few parties highlighted them, while many did not. In line with our theoretical argument, this variation is systematic and can be attributed to lacking incentives for most parties. Especially nominating a candidate at the European level only has a modest positive effect on national parties’ willingness to put the candidates in the spotlight. This lacking commitment to the nominated candidates should be considered in discussions about the reform of the current <i>Spitzenkandidaten</i> system for the 2019 EP elections.
DOI: 10.6084/m9.figshare.6031835.v1
title: Put in the spotlight or largely ignored? Emphasis on the <i>Spitzenkandidaten</i> by political parties in their online campaigns for European elections

description: This article contributes to the debate about the introduction of the <i>Spitzenkandidaten</i> (lead candidates) in the 2014 European Parliament (EP) election. Focusing on parties’ efforts to make the candidates visible to voters, we argue that the multi-level character of these elections creates large differences concerning individual parties’ incentives to promote the <i>Spitzenkandidaten</i> in their campaigns. Analysing a novel dataset of campaign communication on Facebook, we find that only a few parties highlighted them, while many did not. In line with our theoretical argument, this variation is systematic and can be attributed to lacking incentives for most parties. Especially nominating a candidate at the European level only has a modest positive effect on national parties’ willingness to put the candidates in the spotlight. This lacking commitment to the nominated candidates should be considered in discussions about the reform of the current <i>Spitzenkandidaten</i> system for the 2019 EP elections.
DOI: 10.6084/m9.figshare.6031829

description: <br>
DOI: 10.6084/m9.figshare.6031829.v1
title: 1KGP_PJL.xlsx

description: This xlsx file contains information about the PJL sequencing data performed in 1000 Genomes Project.
DOI: 10.6084/m9.figshare.6031829.v2
title: 1KGP_PJL.xlsx

description: This xlsx file contains information about the PJL sequencing data performed in 1000 Genomes Project.
DOI: 10.6084/m9.figshare.6031829.v4
title: 1KGP_PJL.xlsx

description: This xlsx file contains information about the PJL sequencing data performed in 1000 Genomes Project.
DOI: 10.6084/m9.figshare.6031829.v3
title: 1KGP_PJL.xlsx

description: This xlsx file contains information about the PJL sequencing data performed in 1000 Genomes Project.
DOI: 10.6084/m9.figshare.6031790
title: Seed mass diversity along resource gradients: the role of allometric growth rate and size-asymmetric competition

description: Matlab Codes for the paper ‘Seed mass diversity along resource gradients: the role of allometric growth rate and size-asymmetric competition. <br>I recommend downloading all the files and putting them in one directory because all the scripts use functions (which are located in different files). Below, a brief explanation of each script file (other files are functions used therein):1. OneYearDynamics –simulations of growth and competition during a single growing seasons (Figure 1 & 2 in the main article)2. PopulationDynamicsResource –simulations of population dynamics under different resource levels (Figure 3 & 4 in the main article)3. PopulationDynamicsWithMortality –similar to ‘PopulationDynamicsResource’ but assuming mortality (Figure S1 in the supporting material)4. PopulationDynamicsStress similar to ‘PopulationDynamicsResource’ but assuming large seeded species have lower mortality under low levels of soil resources (Figure S2,S3 in the supporting material)5. PopulationDynamicsDisurbance –simulations of population dynamics under different disturbance levels (Figure S4 in the supporting material)<br><br>
DOI: 10.6084/m9.figshare.6031790.v1
title: Seed mass diversity along resource gradients: the role of allometric growth rate and size-asymmetric competition

description: Matlab Codes for the paper ‘Seed mass diversity along resource gradients: the role of allometric growth rate and size-asymmetric competition. <br>I recommend downloading all the files and putting them in one directory because all the scripts use functions (which are located in different files). Below, a brief explanation of each script file (other files are functions used therein):1. OneYearDynamics –simulations of growth and competition during a single growing seasons (Figure 1 & 2 in the main article)2. PopulationDynamicsResource –simulations of population dynamics under different resource levels (Figure 3 & 4 in the main article)3. PopulationDynamicsWithMortality –similar to ‘PopulationDynamicsResource’ but assuming mortality (Figure S1 in the supporting material)4. PopulationDynamicsStress similar to ‘PopulationDynamicsResource’ but assuming large seeded species have lower mortality under low levels of soil resources (Figure S2,S3 in the supporting material)5. PopulationDynamicsDisurbance –simulations of population dynamics under different disturbance levels (Figure S4 in the supporting material)<br><br>
DOI: 10.6084/m9.figshare.6031712
title: Additional file 1 of Performance of in silico prediction tools for the classification of rare BRCA1/2 missense variants in clinical diagnostics

description: Table S1. List of all variants (n=236) from the Classified Variant Set, including reference, functional impact and number of families affected within the cohort of patients from the German Consortium of Hereditary Breast and Ovarian Cancer (as of September 2016). (XLSX 28 kb)
DOI: 10.6084/m9.figshare.6031712.v1
title: Additional file 1 of Performance of in silico prediction tools for the classification of rare BRCA1/2 missense variants in clinical diagnostics

description: Table S1. List of all variants (n=236) from the Classified Variant Set, including reference, functional impact and number of families affected within the cohort of patients from the German Consortium of Hereditary Breast and Ovarian Cancer (as of September 2016). (XLSX 28 kb)
DOI: 10.6084/m9.figshare.6031640
title: Additional file 1: of A retrospective review of 146 active and passive fixation bradycardia lead implantations in 74 dogs undergoing pacemaker implantation in a research setting of short term duration

description: Implantation Procedures and Follow-up Care. Didactic description of the procedures and processes for intracardiac atrial and ventricular lead implantation and follow-up care in the research setting. (ZIP 303 kb)
DOI: 10.6084/m9.figshare.6031640.v1
title: Additional file 1: of A retrospective review of 146 active and passive fixation bradycardia lead implantations in 74 dogs undergoing pacemaker implantation in a research setting of short term duration

description: Implantation Procedures and Follow-up Care. Didactic description of the procedures and processes for intracardiac atrial and ventricular lead implantation and follow-up care in the research setting. (ZIP 303 kb)
DOI: 10.6084/m9.figshare.6031634
title: Additional file 1: of A bibliometric analysis of the global research on biosimilars

description: Dataset 1: Data obtained from Scopus, a .CSV that contain list of studies included. (CSV 6323 kb)
DOI: 10.6084/m9.figshare.6031634.v1
title: Additional file 1: of A bibliometric analysis of the global research on biosimilars

description: Dataset 1: Data obtained from Scopus, a .CSV that contain list of studies included. (CSV 6323 kb)
DOI: 10.6084/m9.figshare.6031610
title: Additional file 6: of Defense against territorial intrusion is associated with DNA methylation changes in the honey bee brain

description: Table S5. Summary of samples and WGBS sequencing. (XLSX 43Â kb)
DOI: 10.6084/m9.figshare.6031610.v1
title: Additional file 6: of Defense against territorial intrusion is associated with DNA methylation changes in the honey bee brain

description: Table S5. Summary of samples and WGBS sequencing. (XLSX 43Â kb)
DOI: 10.6084/m9.figshare.6031595
title: Additional file 5: of Defense against territorial intrusion is associated with DNA methylation changes in the honey bee brain

description: Table S4. Enrichments of Minute-120 suggestive CpGs and transcription factor binding sites in gene regions. (XLSX 190Â kb)
DOI: 10.6084/m9.figshare.6031595.v1
title: Additional file 5: of Defense against territorial intrusion is associated with DNA methylation changes in the honey bee brain

description: Table S4. Enrichments of Minute-120 suggestive CpGs and transcription factor binding sites in gene regions. (XLSX 190Â kb)
DOI: 10.6084/m9.figshare.6031583
title: Additional file 4: of Defense against territorial intrusion is associated with DNA methylation changes in the honey bee brain

description: Table S3. Details of GO enrichments for Differentially expressed genes from Shpigler et al. 2017a [34] that overlap suggestive CpGs. (XLSX 47Â kb)
DOI: 10.6084/m9.figshare.6031583.v1
title: Additional file 4: of Defense against territorial intrusion is associated with DNA methylation changes in the honey bee brain

description: Table S3. Details of GO enrichments for Differentially expressed genes from Shpigler et al. 2017a [34] that overlap suggestive CpGs. (XLSX 47Â kb)
DOI: 10.6084/m9.figshare.6031559
title: Additional file 2: of Defense against territorial intrusion is associated with DNA methylation changes in the honey bee brain

description: Table S2. DMRs between control and aggressive bees at 120Â min post interaction. (XLSX 61Â kb)
DOI: 10.6084/m9.figshare.6031559.v1
title: Additional file 2: of Defense against territorial intrusion is associated with DNA methylation changes in the honey bee brain

description: Table S2. DMRs between control and aggressive bees at 120Â min post interaction. (XLSX 61Â kb)
DOI: 10.6084/m9.figshare.6031547
title: Additional file 1: of Defense against territorial intrusion is associated with DNA methylation changes in the honey bee brain

description: Table S1. DMRs between control and aggressive bees at 5Â min post interaction. (XLSX 36Â kb)
DOI: 10.6084/m9.figshare.6031547.v1
title: Additional file 1: of Defense against territorial intrusion is associated with DNA methylation changes in the honey bee brain

description: Table S1. DMRs between control and aggressive bees at 5Â min post interaction. (XLSX 36Â kb)
DOI: 10.6084/m9.figshare.6031511
title: Additional file 3: of Enhanced expression of histone chaperone APLF associate with breast cancer

description: Expression of EMT associated genes related to Figure S7B. (XLSX 10Â kb)
DOI: 10.6084/m9.figshare.6031511.v1
title: Additional file 3: of Enhanced expression of histone chaperone APLF associate with breast cancer

description: Expression of EMT associated genes related to Figure S7B. (XLSX 10Â kb)
DOI: 10.6084/m9.figshare.6031496
title: Additional file 2: of Enhanced expression of histone chaperone APLF associate with breast cancer

description: GSEA of genes induced in breast cancer metastasis among different repair pathways related to Fig. 2M. (XLSX 42Â kb)
DOI: 10.6084/m9.figshare.6031496.v1
title: Additional file 2: of Enhanced expression of histone chaperone APLF associate with breast cancer

description: GSEA of genes induced in breast cancer metastasis among different repair pathways related to Fig. 2M. (XLSX 42Â kb)
DOI: 10.6084/m9.figshare.6031475
title: Additional file 1: of Enhanced expression of histone chaperone APLF associate with breast cancer

description: Material & methods, Supplementary Figures, Tables. (ZIP 4889Â kb)
DOI: 10.6084/m9.figshare.6031475.v1
title: Additional file 1: of Enhanced expression of histone chaperone APLF associate with breast cancer

description: Material & methods, Supplementary Figures, Tables. (ZIP 4889Â kb)
DOI: 10.6084/m9.figshare.6031436
title: MOESM1 of Utilization of institutional delivery service and associated factors among mothers in North West Ethiopian

description: Additional file 1. This SPSS template contains that data that support the findings of this study.
DOI: 10.6084/m9.figshare.6031436.v1
title: MOESM1 of Utilization of institutional delivery service and associated factors among mothers in North West Ethiopian

description: Additional file 1. This SPSS template contains that data that support the findings of this study.
DOI: 10.6084/m9.figshare.6031427
title: Additional file 4: of High-resolution and high-precision correlation of dark and light layers in the Quaternary hemipelagic sediments of the Japan Sea recovered during IODP Expedition 346

description: Table S2. A list of linear sedimentation rates (LSRs) between two adjacent marker dark layer horizons at each site during the last 1.4 Ma (corresponding to Subunit IA) based on the two age models. (XLSX 69Â kb)
DOI: 10.6084/m9.figshare.6031427.v1
title: Additional file 4: of High-resolution and high-precision correlation of dark and light layers in the Quaternary hemipelagic sediments of the Japan Sea recovered during IODP Expedition 346

description: Table S2. A list of linear sedimentation rates (LSRs) between two adjacent marker dark layer horizons at each site during the last 1.4 Ma (corresponding to Subunit IA) based on the two age models. (XLSX 69Â kb)
DOI: 10.6084/m9.figshare.6031412
title: Additional file 3: of High-resolution and high-precision correlation of dark and light layers in the Quaternary hemipelagic sediments of the Japan Sea recovered during IODP Expedition 346

description: Table S1. Code numbers and ages of marker dark layers and their composite depths (CCSFD_patched) at Sites U1422, U1423, U1424, U1425, U1426, and U1430. (XLSX 21Â kb)
DOI: 10.6084/m9.figshare.6031412.v2
title: Additional file 3: of High-resolution and high-precision correlation of dark and light layers in the Quaternary hemipelagic sediments of the Japan Sea recovered during IODP Expedition 346

description: Table S1. Code numbers and ages of marker dark layers and their composite depths (CCSFD_patched) at Sites U1422, U1423, U1424, U1425, U1426, and U1430. (XLSX 21Â kb)
DOI: 10.6084/m9.figshare.6031412.v1
title: Additional file 3: of High-resolution and high-precision correlation of dark and light layers in the Quaternary hemipelagic sediments of the Japan Sea recovered during IODP Expedition 346

description: Table S1. Code numbers and ages of marker dark layers and their composite depths (CCSFD_patched) at Sites U1422, U1423, U1424, U1425, U1426, and U1430. (XLSX 21Â kb)
DOI: 10.5281/zenodo.4008269
title: Response of tidal duration asymmetry to interplay of coastline reconstruction and sea-level-rise: take South Yellow Sea shelf as an example

description: The data is used in this article, which is "Response of tidal duration asymmetry to interplay of coastline reconstruction and sea-level-rise: take South Yellow Sea shelf as an example"
DOI: 10.5281/zenodo.4008268
title: Response of tidal duration asymmetry to interplay of coastline reconstruction and sea-level-rise: take South Yellow Sea shelf as an example

description: The data is used in this article, which is "Response of tidal duration asymmetry to interplay of coastline reconstruction and sea-level-rise: take South Yellow Sea shelf as an example"
DOI: 10.6084/m9.figshare.6031295
title: Additional file 1: of Hermansky-Pudlak syndrome type 2 manifests with fibrosing lung disease early in childhood

description: Detailed description of the individual cases. Subjects 1 to 6. Table S1. Non-pulmonary signs and symptoms. Table S2. Blinded scoring of CT-scans (number of CTs available at diagnosis (n = 5)/ at follow-up (n = 5); CTs at follow-up and diagnosis available in sub 1-3 and 6, only at follow-up in sub. 2 and only at diagnosis in sub. 4). Scans were analysed for the presence and absence of features listed in the six sections of the lungs. Scoring was not validated. Table S3. Results of bronchoalveolar lavage (BAL) at diagnosis. (DOC 107 kb)
DOI: 10.6084/m9.figshare.6031295.v1
title: Additional file 1: of Hermansky-Pudlak syndrome type 2 manifests with fibrosing lung disease early in childhood

description: Detailed description of the individual cases. Subjects 1 to 6. Table S1. Non-pulmonary signs and symptoms. Table S2. Blinded scoring of CT-scans (number of CTs available at diagnosis (n = 5)/ at follow-up (n = 5); CTs at follow-up and diagnosis available in sub 1-3 and 6, only at follow-up in sub. 2 and only at diagnosis in sub. 4). Scans were analysed for the presence and absence of features listed in the six sections of the lungs. Scoring was not validated. Table S3. Results of bronchoalveolar lavage (BAL) at diagnosis. (DOC 107 kb)
DOI: 10.6084/m9.figshare.6031268
title: MOESM2 of The FieldTrip-SimBio pipeline for EEG forward solutions

description: Additional file 2. Example dataset: tlaLeft.mat, mri.mat, segmentedmri.mat, elec_projected.mat. Example dataset as processed in "Source localization of SEP data" section. It contains: tlaLeft.mat—Preprocessed SEP data (cf. Fig. 4); mri.mat—MRI of the subject (cf. Fig. 5, left); segmentedmri.mat—Segmented MRI (cf. Fig. 5, middle); elec_projected.mat—Electrodes aligned to the surface of the headmodel (cf. Fig. 5, right).