cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.14280727.v1
title: A morning with Louis Pasteur: a short history of the “clean hands”

description: Abstract: This article examines the story of Louis Pasteur from the point of view of a classic movie presented at the Weekly Seminars of the “Oswaldo Cruz Institute”, at the end of the 2017 activities. Although very old, the movie The Story of Louis Pasteur (Warner Bros., 1936) inspired spectators and gave rise to an energetic debate that led the authors to decide for publishing the comments of the Seminar Coordinator, the guest commentator and the audience. The movie communicates to the public the legacy of one of the greatest precursors of the public health history using also fictional characters. The article presents the reliable passages in Pasteur’s biography and the fictional ones, without disrespecting the production of the creators of cinematographic work. The major merit of the movie, one of the first steps towards the policy of scientific diffusion, is to disclose the importance of vaccines and hand hygiene to prevent infectious diseases. The authors argue that the film-maker impeccably captured the scientist’s tenacity in the relentless search for discoveries and Pasteur’s idea that only persistent work can lead to rewarding results, remembering that the context created by previous researchers enabled Pasteur to establish new paradigms. Finally, the authors cite movie passages illustrating realities that are still in force: (i) the inertial resistance of science to new paradigms, illustrated by the medical-scientific community opposing to simple practices proposition, such as washing hands and boiling instruments, and (ii) the excessive confidence, and even arrogance, of some specialists, instead of serenity and humility that arise from committed study and accumulated knowledge.
DOI: 10.6084/m9.figshare.14280723.v1
title: Vulnerability to severe forms of COVID-19: an intra-municipal analysis in the city of Rio de Janeiro, Brazil

description: Given the characteristics of the COVID-19 pandemic and the limited tools for orienting interventions in surveillance, control, and clinical care, the current article aims to identify areas with greater vulnerability to severe cases of the disease in Rio de Janeiro, Brazil, a city characterized by huge social and spatial heterogeneity. In order to identify these areas, the authors prepared an index of vulnerability to severe cases of COVID-19 based on the construction, weighting, and integration of three levels of information: mean number of residents per household and density of persons 60 years or older (both per census tract) and neighborhood tuberculosis incidence rate in the year 2018. The data on residents per household and density of persons 60 years or older were obtained from the 2010 Population Census, and data on tuberculosis incidence were taken from the Brazilian Information System for Notificable Diseases (SINAN). Weighting of the indicators comprising the index used analytic hierarchy process (AHP), and the levels of information were integrated via weighted linear combination with map algebra. Spatialization of the index of vulnerability to severe COVID-19 in the city of Rio de Janeiro reveals the existence of more vulnerable areas in different parts of the city’s territory, reflecting its urban complexity. The areas with greatest vulnerability are located in the North and West Zones of the city and in poor neighborhoods nested within upper-income parts of the South and West Zones. Understanding these conditions of vulnerability can facilitate the development of strategies to monitor the evolution of COVID-19 and orient measures for prevention and health promotion.
DOI: 10.6084/m9.figshare.14280725
title: Effect of the substitution of heating technology on PM 2.5 levels and number of hospitalizations for acute respiratory conditions in Coyhaique, Chile

description: Abstract: Coyhaique (Southern Chile) is one of the most polluted cities in the Americas due to the burning of firewood. In 2016, a mass substitution of residential heating technology was launched to decrease the air concentrations of particulate matter in the winter. Based on time series analyses, the article discusses the effect of this measure on PM2.5 levels and hospitalizations for acute respiratory conditions in individuals under 15 years of age.
DOI: 10.6084/m9.figshare.14280725.v1
title: Effect of the substitution of heating technology on PM 2.5 levels and number of hospitalizations for acute respiratory conditions in Coyhaique, Chile

description: Abstract: Coyhaique (Southern Chile) is one of the most polluted cities in the Americas due to the burning of firewood. In 2016, a mass substitution of residential heating technology was launched to decrease the air concentrations of particulate matter in the winter. Based on time series analyses, the article discusses the effect of this measure on PM2.5 levels and hospitalizations for acute respiratory conditions in individuals under 15 years of age.
DOI: 10.6084/m9.figshare.14280729
title: Brazilian government proposals for actions to prevent and control overweight and obesity from a local perspective

description: Abstract: The article analyzes actions in the prevention and control of overweight and obesity that have been developed in the 92 municipalities (counties) in the state of Rio de Janeiro, Brazil, based on underlying principles in the typology of public policies developed by Lowi and Line of Care for Overweight and Obesity, according to the following analytical dimensions: program actions in prevention and control of obesity, characterization of macro policies according to the Lowi typology, and characterization of macro policies according to the Line of Care for Overweight and Obesity. The study is part of a research project from 2014 to 2018 that aimed to identify the strategies and challenges in the consolidation of the actions planned in the Line of Care for Overweight and Obesity, based on analysis of secondary data and government documents; searches in the municipalities’ official websites; interviews; focus groups; and online questionnaires with health professionals and managers. The documents point to a series of actions such as individual consultations, support groups, health gyms, school health programs, and others, reinforced by the interviewees’ narratives. Even with so many initiatives, the municipalities in the state of Rio de Janeiro face challenges with limited human resources and precarious infrastructure and equipment in the health units. To achieve mobilization in the actions to deal with obesity, the issue should be addressed specifically on the state and local agendas and not diluted among other activities and programs.
DOI: 10.6084/m9.figshare.14280726.v1
title: Rapid immunochromatographic tests for the diagnosis of dengue: a systematic review and meta-analysis

description: Abstract: Dengue is an important arthropod-borne viral disease in terms of morbidity, mortality, economic impact and challenges in vector control. Benchmarks are expensive, time consuming and require trained personnel. Preventing dengue complications with rapid diagnosis has been based on the testing of easy-to-perform optimized immunochromatographic methods (ICT). This is a systematic meta-analysis review of the diagnostic accuracy of IgA, NS1, IgM and/or IgG ICT studies in suspected cases of acute or convalescent dengue, using a combination of RT-PCR, ELISA NS1, IgM IgG or viral isolation as a reference standard. This protocol was registered in PROSPERO (CRD42014009885). Two pairs of reviewers searched the PubMed, BIREME, Science Direct, Scopus, Web of Science, Ovid MEDLINE JBrigs, SCIRUS and EMBASE databases, selected, extracted, and quality-assessed by QUADAS 2. Of 3,783 studies, we selected 57, of which 40 in meta-analyses according to the analyte tested, with high heterogeneity (I2 &gt; 90%), as expected for diagnostic tests. We detected higher pooled sensitivity in acute phase IgA (92.8%) with excellent (90%) specificity. ICT meta-analysis with NS1/IgM/IgG showed 91% sensitivity and 96% specificity. Poorer screening performance was for IgM/IgG ICT (sensitivity = 56%). Thus, the studies with NS1/IgM/IgG ICT showed the best combined performance in the acute phase of the disease.
DOI: 10.6084/m9.figshare.14280728
title: Burden of dengue in the State of Meta, Colombia (2010-2016)

description: Abstract: In Colombia, dengue is a disease of great impact due to its morbidity and mortality, however, studies on the effects of the economic burden at the local level are scarce. Therefore, our study sought to describe the economic burden of dengue epidemics between 2010 and 2016 in the State of Meta, Colombia. A longitudinal study was performed using information from the records of the epidemiological information system (Sistema Nacional de Vigilancia en Salud Pública - SIVIGILA), and the indicator of disability-adjusted life years (DALYs) was determined as an estimator of the burden of dengue. To assess the economic impact, two assessment scenarios were considered (minimum range and maximum range), which allowed the estimate of the effects of the years of life lost (YLLs). Mortality cases presented heterogeneity in the age groups, mainly affecting groups under 15 years and over 65 years, with YLLs raging between 158.58 and 300.38. In total, 2010 showed the highest medical care costs of the study period, with USD 664,123 for women and USD 740,221 for men. In the epidemic years (2010, 2012-2015) between 91,072.3 and 184,175.1 DALYs were lost per million inhabitants, which generated social burden costs higher than the USD 669.6 million. In conclusion, dengue can be considered a disease of high cost at the local level, economically affecting the General Social Security System in Health and social welfare.
DOI: 10.6084/m9.figshare.14280728.v1
title: Burden of dengue in the State of Meta, Colombia (2010-2016)

description: Abstract: In Colombia, dengue is a disease of great impact due to its morbidity and mortality, however, studies on the effects of the economic burden at the local level are scarce. Therefore, our study sought to describe the economic burden of dengue epidemics between 2010 and 2016 in the State of Meta, Colombia. A longitudinal study was performed using information from the records of the epidemiological information system (Sistema Nacional de Vigilancia en Salud Pública - SIVIGILA), and the indicator of disability-adjusted life years (DALYs) was determined as an estimator of the burden of dengue. To assess the economic impact, two assessment scenarios were considered (minimum range and maximum range), which allowed the estimate of the effects of the years of life lost (YLLs). Mortality cases presented heterogeneity in the age groups, mainly affecting groups under 15 years and over 65 years, with YLLs raging between 158.58 and 300.38. In total, 2010 showed the highest medical care costs of the study period, with USD 664,123 for women and USD 740,221 for men. In the epidemic years (2010, 2012-2015) between 91,072.3 and 184,175.1 DALYs were lost per million inhabitants, which generated social burden costs higher than the USD 669.6 million. In conclusion, dengue can be considered a disease of high cost at the local level, economically affecting the General Social Security System in Health and social welfare.
DOI: 10.6084/m9.figshare.14280729.v1
title: Brazilian government proposals for actions to prevent and control overweight and obesity from a local perspective

description: Abstract: The article analyzes actions in the prevention and control of overweight and obesity that have been developed in the 92 municipalities (counties) in the state of Rio de Janeiro, Brazil, based on underlying principles in the typology of public policies developed by Lowi and Line of Care for Overweight and Obesity, according to the following analytical dimensions: program actions in prevention and control of obesity, characterization of macro policies according to the Lowi typology, and characterization of macro policies according to the Line of Care for Overweight and Obesity. The study is part of a research project from 2014 to 2018 that aimed to identify the strategies and challenges in the consolidation of the actions planned in the Line of Care for Overweight and Obesity, based on analysis of secondary data and government documents; searches in the municipalities’ official websites; interviews; focus groups; and online questionnaires with health professionals and managers. The documents point to a series of actions such as individual consultations, support groups, health gyms, school health programs, and others, reinforced by the interviewees’ narratives. Even with so many initiatives, the municipalities in the state of Rio de Janeiro face challenges with limited human resources and precarious infrastructure and equipment in the health units. To achieve mobilization in the actions to deal with obesity, the issue should be addressed specifically on the state and local agendas and not diluted among other activities and programs.
DOI: 10.6084/m9.figshare.14280734
title: Predictive Mean Matching as an alternative imputation method to hot deck in Vigitel

description: This study aimed to describe the estimated means for weight, height, and body mass index (BMI) according to two imputation methods, using data from Vigitel (Risk and Protective Factors Surveillance System for Chronic Non-Communicable Diseases Through Telephone Interview). This was a cross-sectional study that used secondary data from the Vigitel survey from 2006 to 2017. The two imputation methods used in the study were hot deck and Predictive Mean Matching (PMM). The weight and height variables imputed by hot deck were provided by Vigitel. Two models were conducted with PMM: (i) explanatory variables - city, sex, age in years, race/color, and schooling; (ii) explanatory variables - city, sex, and age in years. Weight and height were the outcome variables in the two models. PMM combines linear regression and random selection of the value for imputation. Linear prediction is used as a measure of distance between the missing value and the possible donors, thereby creating the virtual space with the candidate cases for yielding the value for imputation. One of the candidates from the pool is randomly selected, and its value is assigned to the missing unit. BMI was calculated by dividing weight in kilograms by height squared. The result shows the means and standard deviations for weight, height, and BMI according to imputation method and year. The estimates used the survey module from Stata, which considers the sampling effects. The mean values for weight, height, and BMI estimated by hot deck and PMM were similar. The results with the Vigitel data suggest the applicability of PMM to the set of health surveys.
DOI: 10.6084/m9.figshare.14280732
title: Life expectancy with negative physical oral health impact on quality of life in older adults

description: Abstract: Oral impairments can affect overall health and life expectancy in older adults. Our study evaluates the life expectancy with negative physical oral health impact on quality of life (POHIQoL) among older adults. Life expectancy with negative POHIQoL was estimated by the Sullivan method, using the prevalence of POHIQoL - obtained in the Health, Well-being and Ageing (SABE Study); and official mortality data for adults aged 60 years or older living in São Paulo, Brazil. Between 2000 and 2010, negative POHIQoL increased from 23.4% (95%CI: 20.2-26.9) to 30.4% (95%CI: 27.0-34.3) among older adults; total life expectancy increased from 22 and 17.5 to 23.7 and 19.4 years among 60-year-old women and men, respectively; and the proportion of remaining years to be lived with negative POHIQoL increased from 25.1% to 32.1% for the same age group. In both years, individuals aged 60 years with lower education level were expected to live more years with negative POHIQoL when compared with the most schooled ones (2000: 15.9 [95%CI: 15.0-16.8] vs. 14.3 [95%CI: 13.7-14.8]; 2010: 16.3 [95%CI: 15.1-17.4] vs. 14.1 [95%CI: 13.2-15.1]). Similarly, women were expected to live more years with negative POHIQoL than men. Within ten years, life expectancy with negative POHIQoL increased, as well as the existence of inequalities in sex and education level among Brazilian older adults. Expansion in coverage and focus on equity in dental care are still necessary to overcome persistent dental-related problems and inequalities and, therefore, contribute to healthy ageing.
DOI: 10.6084/m9.figshare.14280730
title: Assessment of blood biomarkers in adolescents classified by body mass index and body fat percentage

description: Abstract: The study aimed to compare biomarkers in groups of adolescents classified simultaneously according to body mass index (BMI) and body fat percentage measured by air displacement plethysmography. This was a cross-sectional study with 533 adolescents 18 to 19 years of age in São Luís, Maranhão, Brazil. BMI was classified as adequate (&lt; 25kg/m2) versus excess weight (≥ 25kg/m2). High body fat percentage was defined as ≥ 25% for males and ≥ 30% for females. The adolescents were classified in four groups: “normal weight” (adequate BMI and body fat percentage), “normal weight obese” (adequate BMI with high body fat percentage), “excess weight with adequate body fat percentage”, and “excess weight with high body fat percentage”. Girls showed higher proportions of “normal weight obesity” (15.6%) and “excess weight with high body fat percentage” (17.1%). “Normal weight obese” adolescents exhibited higher mean values for total cholesterol (172.5mg/dL) and LDL-cholesterol (103.5mg/dL). Those with “excess weight and high body fat percentage” showed lower mean HDL-cholesterol (43.2mg/dL) compared to the other groups, higher mean interleukin-6 (2.7pg/mL) than “normal weight” and “excess weight and adequate body fat percentage” adolescents, and higher median triglycerides (114.0mg/dL) and C-reactive protein (0.14ng/mL) than “normal weight” and “normal weight obese” adolescents. Those with “excess weight and adequate body fat percentage” exhibited the same C-reactive protein levels as those with “excess weight and high body fat percentage”. Assessment of nutritional status by BMI alone is limited, since 6.8% of the adolescents presented high body fat percentage despite normal BMI, and those who were “normal weight obese” had two biomarkers that were worse than for adolescents with “excess weight and high body fat percentage”.
DOI: 10.6084/m9.figshare.14280730.v1
title: Assessment of blood biomarkers in adolescents classified by body mass index and body fat percentage

description: Abstract: The study aimed to compare biomarkers in groups of adolescents classified simultaneously according to body mass index (BMI) and body fat percentage measured by air displacement plethysmography. This was a cross-sectional study with 533 adolescents 18 to 19 years of age in São Luís, Maranhão, Brazil. BMI was classified as adequate (&lt; 25kg/m2) versus excess weight (≥ 25kg/m2). High body fat percentage was defined as ≥ 25% for males and ≥ 30% for females. The adolescents were classified in four groups: “normal weight” (adequate BMI and body fat percentage), “normal weight obese” (adequate BMI with high body fat percentage), “excess weight with adequate body fat percentage”, and “excess weight with high body fat percentage”. Girls showed higher proportions of “normal weight obesity” (15.6%) and “excess weight with high body fat percentage” (17.1%). “Normal weight obese” adolescents exhibited higher mean values for total cholesterol (172.5mg/dL) and LDL-cholesterol (103.5mg/dL). Those with “excess weight and high body fat percentage” showed lower mean HDL-cholesterol (43.2mg/dL) compared to the other groups, higher mean interleukin-6 (2.7pg/mL) than “normal weight” and “excess weight and adequate body fat percentage” adolescents, and higher median triglycerides (114.0mg/dL) and C-reactive protein (0.14ng/mL) than “normal weight” and “normal weight obese” adolescents. Those with “excess weight and adequate body fat percentage” exhibited the same C-reactive protein levels as those with “excess weight and high body fat percentage”. Assessment of nutritional status by BMI alone is limited, since 6.8% of the adolescents presented high body fat percentage despite normal BMI, and those who were “normal weight obese” had two biomarkers that were worse than for adolescents with “excess weight and high body fat percentage”.
DOI: 10.6084/m9.figshare.14280734.v1
title: Predictive Mean Matching as an alternative imputation method to hot deck in Vigitel

description: This study aimed to describe the estimated means for weight, height, and body mass index (BMI) according to two imputation methods, using data from Vigitel (Risk and Protective Factors Surveillance System for Chronic Non-Communicable Diseases Through Telephone Interview). This was a cross-sectional study that used secondary data from the Vigitel survey from 2006 to 2017. The two imputation methods used in the study were hot deck and Predictive Mean Matching (PMM). The weight and height variables imputed by hot deck were provided by Vigitel. Two models were conducted with PMM: (i) explanatory variables - city, sex, age in years, race/color, and schooling; (ii) explanatory variables - city, sex, and age in years. Weight and height were the outcome variables in the two models. PMM combines linear regression and random selection of the value for imputation. Linear prediction is used as a measure of distance between the missing value and the possible donors, thereby creating the virtual space with the candidate cases for yielding the value for imputation. One of the candidates from the pool is randomly selected, and its value is assigned to the missing unit. BMI was calculated by dividing weight in kilograms by height squared. The result shows the means and standard deviations for weight, height, and BMI according to imputation method and year. The estimates used the survey module from Stata, which considers the sampling effects. The mean values for weight, height, and BMI estimated by hot deck and PMM were similar. The results with the Vigitel data suggest the applicability of PMM to the set of health surveys.
DOI: 10.6084/m9.figshare.14280735
title: The COVID-19 pandemic in Brazil: analysis of supply and demand of hospital and ICU beds and mechanical ventilators under different scenarios

description: This study aims to analyze the pressure on the Brazilian health system from the additional demand created by COVID-19. The authors performed a series of simulations to estimate the demand for hospital beds (health micro-regions) as well as to ICU beds, and mechanical ventilators (health macro-regions) under different scenarios of intensity (infection rates equivalent to 0.01, 0.1, and 1 case por 100 inhabitants) and time horizons (1, 3, and 6 months). The results reveal a critical situation in the system for meeting this potential demand, with numerous health micro-regions and macro-regions operating beyond their capacity, compromising the care for patients, especially those with more severe symptoms. The study presents three relevant messages. First, it is necessary to slow the spread of COVID-19 in the Brazilian population, allowing more time for the reorganization of the supply and relieve the pressure on the health system. Second, the expansion of the number of available beds will be the key. Even if the private sector helps offset the deficit, the combined supply from the two sectors (public and private) would be insufficient in various macro-regions. The construction of field hospitals is important, both in places with a history of “hospital deserts” and in those already pressured by demand. The third message involves the regionalized organization of health services, whose design may be adequate in situations of routine demand, but which suffer additional challenges during pandemics, especially if patients have to travel long distances to receive care.