cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.27195747.v1
title: Elevated triglyceride-glucose index predicts poor outcome in patients with intracranial atherosclerotic stenosis after extracranial and intracranial bypass

description: The triglyceride-glucose (TyG) index, a novel reliable biomarker for IR that incorporates blood glucose and triglyceride, is linked to intracranial atherosclerotic stenosis (ICAS). In this study, we aimed to further investigate the association between the TyG index and the outcomes of ICAS patients following extracranial-to-intracranial (EC-IC) bypass grafting. 489 ICAS patients who underwent EC-IC bypass between Jan 2009 and Jan 2022 at our hospital were retrospectively collected. The major adverse cardiac and cerebrovascular events (MACCEs), and anastomotic restenosis, both of which are critical factors leading to poor prognosis of ICAS patients after EC-IC bypass, were mainly recorded and analyzed. Kaplan–Meier survival curve and Log-rank tests were sequentially conducted. Cox regression model was used to investigate the association between the TyG index and MACCEs & anastomotic stenosis. C-statistics, continuous net reclassification improvement (NRI), and integrated discrimination improvement (IDI) evaluated the incremental predictive value of the TyG index. A higher incidence of MACCEs and anastomotic stenosis was found in higher-tertile TyG index group. The TyG index was significantly associated with an increased risk of MACCEs and anastomotic stenosis, independent of confounding factors, with a value of HR (1.30, 95%CI 1.10-1.51, <i>p</i> &lt; 0.001) and (1.27, 95%CI 1.16-1.40, <i>p</i> &lt; 0.001) respectively. The area under the curve (AUC) in the model with the TyG index for predicting the occurrence of MACCEs and anastomotic stenosis were 0.708 (95%CI 0.665-0.748) and 0.731 (95%CI 0.689-0.770) respectively. The addition of the TyG index significantly improved the global performance of the baseline model according to the C-statistics, NRI, and IDI (All <i>p</i> &lt; 0.05). Higher TyG levels were associated with poorer outcomes in ICAS patients after EC-IC bypass. TyG could be a key factor in managing ICAS risk and standardizing the indications for EC-IC bypass.
DOI: 10.6084/m9.figshare.27951774
title: Haemoglobin levels are associated with echocardiographic measures in a Finnish midlife population

description: Within normal variation, higher haemoglobin (Hb) levels are associated with unhealthier body composition, adverse metabolism and cardiovascular disease (CVD)-related mortality. Global longitudinal strain (GLS) is a direct, well validated and reproducible echocardiographic measure for the evaluation of cardiac contractile function, providing additional prognostic value for prediction of a variety of cardiac events. This study investigated the relation between Hb levels and cardiac function measures, including GLS, in a Finnish midlife population. Echocardiography was carried out in a subpopulation of the Northern Finland Birth Cohort 1966 at age of 46 (<i>n</i> = 1155). GLS was available for <i>n</i> = 796. Subjects with diabetes, severe cardiac diseases, echocardiographic abnormalities, heart rate ≥85 bpm during echocardiography or Hb level outside the Finnish reference intervals (117–155 g/L for females and 134–167 g/L for males) were excluded from the analysis. The study population included 635 subjects (46% males). The data were analysed in Hb tertiles and in multivariable linear regression models. The highest Hb tertile had adverse anthropometric and metabolic parameters compared to other Hb tertiles. Of the studied echocardiographic parameters, the highest Hb tertile had the highest left ventricular mass (LVM, <i>p</i> &lt; .01), LVM index (LVMi, <i>p</i> &lt; .05), LV end-diastolic volume (LVEDV, <i>p</i> &lt; .05), posterior wall thickness (PWT, <i>p</i> &lt; .001), relative wall thickness (RWT, <i>p</i> &lt; .05) and the lowest absolute GLS (<i>p</i> &lt; .001) but no difference in LV ejection fraction (LVEF) was observed between the Hb tertiles. In linear models, when adjusted for covariates, Hb levels were associated positively and independently with GLS (<i>B</i> = 0.153 [0.071; 0.235]) and LVM (<i>B</i> = 0.272 [0.193; 0.350]). Higher Hb levels are associated with an adverse metabolic and inflammatory profile and more adverse cardiac function measures, including GLS, in both sexes in midlife.
DOI: 10.6084/m9.figshare.27951774.v1
title: Haemoglobin levels are associated with echocardiographic measures in a Finnish midlife population

description: Within normal variation, higher haemoglobin (Hb) levels are associated with unhealthier body composition, adverse metabolism and cardiovascular disease (CVD)-related mortality. Global longitudinal strain (GLS) is a direct, well validated and reproducible echocardiographic measure for the evaluation of cardiac contractile function, providing additional prognostic value for prediction of a variety of cardiac events. This study investigated the relation between Hb levels and cardiac function measures, including GLS, in a Finnish midlife population. Echocardiography was carried out in a subpopulation of the Northern Finland Birth Cohort 1966 at age of 46 (<i>n</i> = 1155). GLS was available for <i>n</i> = 796. Subjects with diabetes, severe cardiac diseases, echocardiographic abnormalities, heart rate ≥85 bpm during echocardiography or Hb level outside the Finnish reference intervals (117–155 g/L for females and 134–167 g/L for males) were excluded from the analysis. The study population included 635 subjects (46% males). The data were analysed in Hb tertiles and in multivariable linear regression models. The highest Hb tertile had adverse anthropometric and metabolic parameters compared to other Hb tertiles. Of the studied echocardiographic parameters, the highest Hb tertile had the highest left ventricular mass (LVM, <i>p</i> &lt; .01), LVM index (LVMi, <i>p</i> &lt; .05), LV end-diastolic volume (LVEDV, <i>p</i> &lt; .05), posterior wall thickness (PWT, <i>p</i> &lt; .001), relative wall thickness (RWT, <i>p</i> &lt; .05) and the lowest absolute GLS (<i>p</i> &lt; .001) but no difference in LV ejection fraction (LVEF) was observed between the Hb tertiles. In linear models, when adjusted for covariates, Hb levels were associated positively and independently with GLS (<i>B</i> = 0.153 [0.071; 0.235]) and LVM (<i>B</i> = 0.272 [0.193; 0.350]). Higher Hb levels are associated with an adverse metabolic and inflammatory profile and more adverse cardiac function measures, including GLS, in both sexes in midlife.
DOI: 10.6084/m9.figshare.27195747
title: Elevated triglyceride-glucose index predicts poor outcome in patients with intracranial atherosclerotic stenosis after extracranial and intracranial bypass

description: The triglyceride-glucose (TyG) index, a novel reliable biomarker for IR that incorporates blood glucose and triglyceride, is linked to intracranial atherosclerotic stenosis (ICAS). In this study, we aimed to further investigate the association between the TyG index and the outcomes of ICAS patients following extracranial-to-intracranial (EC-IC) bypass grafting. 489 ICAS patients who underwent EC-IC bypass between Jan 2009 and Jan 2022 at our hospital were retrospectively collected. The major adverse cardiac and cerebrovascular events (MACCEs), and anastomotic restenosis, both of which are critical factors leading to poor prognosis of ICAS patients after EC-IC bypass, were mainly recorded and analyzed. Kaplan–Meier survival curve and Log-rank tests were sequentially conducted. Cox regression model was used to investigate the association between the TyG index and MACCEs & anastomotic stenosis. C-statistics, continuous net reclassification improvement (NRI), and integrated discrimination improvement (IDI) evaluated the incremental predictive value of the TyG index. A higher incidence of MACCEs and anastomotic stenosis was found in higher-tertile TyG index group. The TyG index was significantly associated with an increased risk of MACCEs and anastomotic stenosis, independent of confounding factors, with a value of HR (1.30, 95%CI 1.10-1.51, <i>p</i> &lt; 0.001) and (1.27, 95%CI 1.16-1.40, <i>p</i> &lt; 0.001) respectively. The area under the curve (AUC) in the model with the TyG index for predicting the occurrence of MACCEs and anastomotic stenosis were 0.708 (95%CI 0.665-0.748) and 0.731 (95%CI 0.689-0.770) respectively. The addition of the TyG index significantly improved the global performance of the baseline model according to the C-statistics, NRI, and IDI (All <i>p</i> &lt; 0.05). Higher TyG levels were associated with poorer outcomes in ICAS patients after EC-IC bypass. TyG could be a key factor in managing ICAS risk and standardizing the indications for EC-IC bypass.
DOI: 10.15468/dl.53rf8p
title: Occurrence Download

description: A dataset containing 32 species occurrences available in GBIF matching the query:
{
 "and" : [
 {
 "and" : [
 "HasGeospatialIssue is false",
 "HasCoordinate is true",
 "OccurrenceStatus is Present",
 {
 "not" : {
 "BasisOfRecord" : [
 "is one of (Fossil, Living Specimen)"
 ]
 }
 }
 ]
 },
 "TaxonKey is one of (Senecio articulatus (L.fil.) Sch.Bip.)"
 ]
}

 The dataset includes 32 records from 9 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0014539-241126133413365/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.6084/m9.figshare.25044044
title: Brain-Derived neurotrophic factor and inflammatory biomarkers are unaffected by acute and chronic intermittent hypoxic-hyperoxic exposure in geriatric patients: a randomized controlled trial

description: Animal and human studies have shown that exposure to hypoxia can increase brain-derived neurotrophic factor (BDNF) protein transcription and reduce systematic inflammatory cytokine response. Therefore, the aim of this study was to investigate the acute and chronic effects of intermittent hypoxic-hyperoxic exposure (IHHE) prior to aerobic exercise on BDNF, interleukin-6 (IL-6), and C-reactive protein (CRP) blood levels in geriatric patients. Twenty-five geriatric patients (83.1 ± 5.0 yrs, 71.1 ± 10.0 kg, 1.8 ± 0.9 m) participated in a placebo-controlled, single-blinded trial and were randomly assigned to either an intervention (IG) or control group (CG) performing an aerobic cycling training (17 sessions, 20 min·session<sup>−1</sup>, 3 sessions·week<sup>−1</sup>). Prior to aerobic cycling exercise, the IG was additionally exposed to IHHE for 30 min, whereas the CG received continuous normoxic air. Blood samples were taken immediately before (pre-exercise) and 10 min (post-exercise) after the first session as well as 48 h (post-training) after the last session to determine serum (BDNF<sub>S</sub>) and plasma BDNF (BDNF<sub>P</sub>), IL-6, and CRP levels. Intervention effects were analyzed using a 2 x 2 analysis of covariance with repeated measures. Results were interpreted based on effect sizes with a medium effect considered as meaningful (η<sub>p</sub><sup>2 </sup>≥ 0.06, <i>d</i> ≥ 0.5). CRP was moderately higher (<i>d</i> = 0.51) in the CG compared to the IG at baseline. IHHE had no acute effect on BDNF<sub>S</sub> (η<sub>p</sub><sup>2 </sup>= 0.01), BDNF<sub>P</sub> (η<sub>p</sub><sup>2 </sup>&lt; 0.01), BDNF serum/plasma-ratio (η<sub>p</sub><sup>2 </sup>&lt; 0.01), IL-6 (η<sub>p</sub><sup>2 </sup>&lt; 0.01), or CRP (η<sub>p</sub><sup>2 </sup>= 0.04). After the 6-week intervention, an interaction was found for BDNF serum/plasma-ratio (η<sub>p</sub><sup>2 </sup>= 0.06) but not for BDNF<sub>S</sub> (η<sub>p</sub><sup>2 </sup>= 0.04), BDNF<sub>P</sub> (η<sub>p</sub><sup>2 </sup>&lt; 0.01), IL-6 (η<sub>p</sub><sup>2 </sup>&lt; 0.01), or CRP (η<sub>p</sub><sup>2 </sup>&lt; 0.01). BDNF serum/plasma-ratio increased from pre-exercise to post-training (<i>d</i> = 0.67) in the CG compared to the IG (<i>d</i> = 0.51). A main effect of time was found for BDNF<sub>P</sub> (η<sub>p</sub><sup>2 </sup>= 0.09) but not for BDNF<sub>S</sub> (η<sub>p</sub><sup>2 </sup>= 0.02). Within-group post-hoc analyses revealed a training-related reduction in BDNF<sub>P</sub> in the IG and CG by 46.1% (<i>d</i> = 0.73) and 24.7% (<i>d</i> = 0.57), respectively. The addition of 30 min IHHE prior to 20 min aerobic cycling seems not to be effective to increase BDNF<sub>S</sub> and BDNF<sub>P</sub> or to reduce IL-6 and CRP levels in geriatric patients after a 6-week intervention. The study was retrospectively registered at drks.de (DRKS-ID: DRKS00025130).
DOI: 10.6084/m9.figshare.25044044.v1
title: Brain-Derived neurotrophic factor and inflammatory biomarkers are unaffected by acute and chronic intermittent hypoxic-hyperoxic exposure in geriatric patients: a randomized controlled trial

description: Animal and human studies have shown that exposure to hypoxia can increase brain-derived neurotrophic factor (BDNF) protein transcription and reduce systematic inflammatory cytokine response. Therefore, the aim of this study was to investigate the acute and chronic effects of intermittent hypoxic-hyperoxic exposure (IHHE) prior to aerobic exercise on BDNF, interleukin-6 (IL-6), and C-reactive protein (CRP) blood levels in geriatric patients. Twenty-five geriatric patients (83.1 ± 5.0 yrs, 71.1 ± 10.0 kg, 1.8 ± 0.9 m) participated in a placebo-controlled, single-blinded trial and were randomly assigned to either an intervention (IG) or control group (CG) performing an aerobic cycling training (17 sessions, 20 min·session<sup>−1</sup>, 3 sessions·week<sup>−1</sup>). Prior to aerobic cycling exercise, the IG was additionally exposed to IHHE for 30 min, whereas the CG received continuous normoxic air. Blood samples were taken immediately before (pre-exercise) and 10 min (post-exercise) after the first session as well as 48 h (post-training) after the last session to determine serum (BDNF<sub>S</sub>) and plasma BDNF (BDNF<sub>P</sub>), IL-6, and CRP levels. Intervention effects were analyzed using a 2 x 2 analysis of covariance with repeated measures. Results were interpreted based on effect sizes with a medium effect considered as meaningful (η<sub>p</sub><sup>2 </sup>≥ 0.06, <i>d</i> ≥ 0.5). CRP was moderately higher (<i>d</i> = 0.51) in the CG compared to the IG at baseline. IHHE had no acute effect on BDNF<sub>S</sub> (η<sub>p</sub><sup>2 </sup>= 0.01), BDNF<sub>P</sub> (η<sub>p</sub><sup>2 </sup>&lt; 0.01), BDNF serum/plasma-ratio (η<sub>p</sub><sup>2 </sup>&lt; 0.01), IL-6 (η<sub>p</sub><sup>2 </sup>&lt; 0.01), or CRP (η<sub>p</sub><sup>2 </sup>= 0.04). After the 6-week intervention, an interaction was found for BDNF serum/plasma-ratio (η<sub>p</sub><sup>2 </sup>= 0.06) but not for BDNF<sub>S</sub> (η<sub>p</sub><sup>2 </sup>= 0.04), BDNF<sub>P</sub> (η<sub>p</sub><sup>2 </sup>&lt; 0.01), IL-6 (η<sub>p</sub><sup>2 </sup>&lt; 0.01), or CRP (η<sub>p</sub><sup>2 </sup>&lt; 0.01). BDNF serum/plasma-ratio increased from pre-exercise to post-training (<i>d</i> = 0.67) in the CG compared to the IG (<i>d</i> = 0.51). A main effect of time was found for BDNF<sub>P</sub> (η<sub>p</sub><sup>2 </sup>= 0.09) but not for BDNF<sub>S</sub> (η<sub>p</sub><sup>2 </sup>= 0.02). Within-group post-hoc analyses revealed a training-related reduction in BDNF<sub>P</sub> in the IG and CG by 46.1% (<i>d</i> = 0.73) and 24.7% (<i>d</i> = 0.57), respectively. The addition of 30 min IHHE prior to 20 min aerobic cycling seems not to be effective to increase BDNF<sub>S</sub> and BDNF<sub>P</sub> or to reduce IL-6 and CRP levels in geriatric patients after a 6-week intervention. The study was retrospectively registered at drks.de (DRKS-ID: DRKS00025130).
DOI: 10.6084/m9.figshare.27900092
title: Exosomal long non-coding RNA-LINC00839 promotes lung adenocarcinoma progression by activating NF-κB signaling pathway

description: Lung adenocarcinoma is the most common type of lung cancer, accounting for approximately 40% of all lung cancer cases, and has the highest incidence among lung cancer subtypes. Recent studies have suggested that long non-coding RNAs (lncRNAs) play a crucial role in the initiation and progression of lung adenocarcinoma. Based on integrative analysis through databases, we screened Long intergenic non-protein coding RNA 00839 (LINC00839) as one of the most highly upregulated lncRNAs in lung adenocarcinoma. <i>In vitro</i> and <i>in vivo</i> experiments demonstrated that LINC00839 promotes lung adenocarcinoma proliferation, migration, and invasion and that it is present in exosomes secreted by lung adenocarcinoma cells. In the cytoplasm, LINC00839 regulates the Toll-like receptor 4 (TLR4)/NF-κB signaling pathway by acting as a molecular sponge of miR-17-5p, thereby influencing the biological behavior of lung adenocarcinoma cells. LINC00839 binds to Polypyrimidine tract binding protein 1 (PTBP1) in the nucleus to regulate the nuclear translocation of NF-κB p65 molecules and, consequently, the transcription of downstream molecules. Our study confirmed that LINC00839 promotes the biological progression of lung adenocarcinoma by performing dual roles in the cytoplasm and nucleus to co-regulate the NF-κB signaling pathway.
DOI: 10.6084/m9.figshare.27900092.v1
title: Exosomal long non-coding RNA-LINC00839 promotes lung adenocarcinoma progression by activating NF-κB signaling pathway

description: Lung adenocarcinoma is the most common type of lung cancer, accounting for approximately 40% of all lung cancer cases, and has the highest incidence among lung cancer subtypes. Recent studies have suggested that long non-coding RNAs (lncRNAs) play a crucial role in the initiation and progression of lung adenocarcinoma. Based on integrative analysis through databases, we screened Long intergenic non-protein coding RNA 00839 (LINC00839) as one of the most highly upregulated lncRNAs in lung adenocarcinoma. <i>In vitro</i> and <i>in vivo</i> experiments demonstrated that LINC00839 promotes lung adenocarcinoma proliferation, migration, and invasion and that it is present in exosomes secreted by lung adenocarcinoma cells. In the cytoplasm, LINC00839 regulates the Toll-like receptor 4 (TLR4)/NF-κB signaling pathway by acting as a molecular sponge of miR-17-5p, thereby influencing the biological behavior of lung adenocarcinoma cells. LINC00839 binds to Polypyrimidine tract binding protein 1 (PTBP1) in the nucleus to regulate the nuclear translocation of NF-κB p65 molecules and, consequently, the transcription of downstream molecules. Our study confirmed that LINC00839 promotes the biological progression of lung adenocarcinoma by performing dual roles in the cytoplasm and nucleus to co-regulate the NF-κB signaling pathway.
DOI: 10.6084/m9.figshare.25183809
title: Bowel health, defecation patterns and nutrient intake following adoption of a vegan diet: a randomized-controlled trial

description: The beneficial effects of a plant-based diet on gut microbiota diversity are well documented, however, its impact on clinical bowel health and defecation patterns are less well understood. Vegetarian diets have been associated with a higher bowel movement (BM) frequency as well as softer stools in cross-sectional studies. The effects of the de-novo adoption of a vegan diet on bowel health, however, have never been investigated in a randomized-controlled trial. The present study examined bowel health and defecation patterns in relation to diet and nutrient intake in a young and healthy sample of <i>n</i> = 65 physically-active German university students who were randomly assigned to either a vegan or a meat-rich diet for eight weeks. Bowel health assessment included the Bristol Stool Form Scale (BSFS), the Gastrointestinal Quality of Life Index (GIQLI) and the Cleveland Clinic Fecal Incontinence Score (CCFIS). Nutrient intake was assessed using weighed food diaries. The study was prospectively registered at the German Clinical Trial Register (DRKS00031541). Weekly BM frequency slightly increased in vegans, whereas it remained unaltered in participants assigned to a meat-rich diet. Fiber intake increased significantly in vegans (34.89 (18.46) g/d) whereas it decreased in those assigned to the meat-rich group (22.79 (12.5) g/d). No significant intergroup differences in BSFS and CCFIS patterns were observed. Adoption of a vegan diet neither resulted in a transient increase in abdominal discomfort nor in a decreased gastrointestinal quality of life, which was comparable across the diet groups. The short-term <i>de-novo</i> adoption of a vegan diet did not negatively affect markers of bowel health in this study.
DOI: 10.6084/m9.figshare.25183809.v1
title: Bowel health, defecation patterns and nutrient intake following adoption of a vegan diet: a randomized-controlled trial

description: The beneficial effects of a plant-based diet on gut microbiota diversity are well documented, however, its impact on clinical bowel health and defecation patterns are less well understood. Vegetarian diets have been associated with a higher bowel movement (BM) frequency as well as softer stools in cross-sectional studies. The effects of the de-novo adoption of a vegan diet on bowel health, however, have never been investigated in a randomized-controlled trial. The present study examined bowel health and defecation patterns in relation to diet and nutrient intake in a young and healthy sample of <i>n</i> = 65 physically-active German university students who were randomly assigned to either a vegan or a meat-rich diet for eight weeks. Bowel health assessment included the Bristol Stool Form Scale (BSFS), the Gastrointestinal Quality of Life Index (GIQLI) and the Cleveland Clinic Fecal Incontinence Score (CCFIS). Nutrient intake was assessed using weighed food diaries. The study was prospectively registered at the German Clinical Trial Register (DRKS00031541). Weekly BM frequency slightly increased in vegans, whereas it remained unaltered in participants assigned to a meat-rich diet. Fiber intake increased significantly in vegans (34.89 (18.46) g/d) whereas it decreased in those assigned to the meat-rich group (22.79 (12.5) g/d). No significant intergroup differences in BSFS and CCFIS patterns were observed. Adoption of a vegan diet neither resulted in a transient increase in abdominal discomfort nor in a decreased gastrointestinal quality of life, which was comparable across the diet groups. The short-term <i>de-novo</i> adoption of a vegan diet did not negatively affect markers of bowel health in this study.