cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.14236553
title: Supplementary Material for: Longitudinal Changes in Prorenin and Renin in the Chronic Renal Insufficiency Cohort

description: <b><i>Introduction:</i></b> Prorenin, a precursor of renin, and renin play an important role in regulation of the renin-angiotensin system. More recently, receptor-bound prorenin has been shown to activate intracellular signaling pathways that mediate fibrosis, independent of angiotensin II. Prorenin and renin may thus be of physiologic significance in CKD, but their plasma concentrations have not been well characterized in CKD. <b><i>Methods:</i></b> We evaluated distribution and longitudinal changes of prorenin and renin concentrations in the plasma samples collected at follow-up years 1, 2, 3, and 5 of the Chronic Renal Insufficiency Cohort (CRIC) study, an ongoing longitudinal observational study of 3,939 adults with CKD. Descriptive statistics and multivariable regression of log-transformed values were used to describe cross-sectional and longitudinal variation and associations with participant characteristics. <b><i>Results:</i></b> A total of 3,361 CRIC participants had plasma available for analysis at year 1. The mean age (±standard deviation, SD) was 59 ± 11 years, and the mean estimated glomerular filtration rate (eGFR, ± SD) was 43 ± 17 mL/min per 1.73 m<sup>2</sup>. Median (interquartile range) values of plasma prorenin and renin at study entry were 4.4 (2.1, 8.8) ng/mL and 2.0 (0.8, 5.9) ng/dL, respectively. Prorenin and renin were positively correlated (Spearman correlation 0.51, <i>p</i> &lt; 0.001) with each other. Women and non-Hispanic blacks had lower prorenin and renin values at year 1. Diabetes, lower eGFR, and use of angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, statins, and diuretics were associated with higher levels. Prorenin and renin decreased by a mean of 2 and 5% per year, respectively. Non-Hispanic black race and eGFR &lt;30 mL/min/1.73 m<sup>2</sup> at year 1 predicted a steeper decrease in prorenin and renin over time. In addition, each increase in urinary sodium excretion by 2 SDs at year 1 increased prorenin and renin levels by 4 and 5% per year, respectively. <b><i>Discussion/Conclusions:</i></b> The cross-sectional clinical factors associated with prorenin and renin values were similar. Overall, both plasma prorenin and renin concentrations decreased over the years, particularly in those with severe CKD at study entry.
DOI: 10.6084/m9.figshare.14236553.v1
title: Supplementary Material for: Longitudinal Changes in Prorenin and Renin in the Chronic Renal Insufficiency Cohort

description: <b><i>Introduction:</i></b> Prorenin, a precursor of renin, and renin play an important role in regulation of the renin-angiotensin system. More recently, receptor-bound prorenin has been shown to activate intracellular signaling pathways that mediate fibrosis, independent of angiotensin II. Prorenin and renin may thus be of physiologic significance in CKD, but their plasma concentrations have not been well characterized in CKD. <b><i>Methods:</i></b> We evaluated distribution and longitudinal changes of prorenin and renin concentrations in the plasma samples collected at follow-up years 1, 2, 3, and 5 of the Chronic Renal Insufficiency Cohort (CRIC) study, an ongoing longitudinal observational study of 3,939 adults with CKD. Descriptive statistics and multivariable regression of log-transformed values were used to describe cross-sectional and longitudinal variation and associations with participant characteristics. <b><i>Results:</i></b> A total of 3,361 CRIC participants had plasma available for analysis at year 1. The mean age (±standard deviation, SD) was 59 ± 11 years, and the mean estimated glomerular filtration rate (eGFR, ± SD) was 43 ± 17 mL/min per 1.73 m<sup>2</sup>. Median (interquartile range) values of plasma prorenin and renin at study entry were 4.4 (2.1, 8.8) ng/mL and 2.0 (0.8, 5.9) ng/dL, respectively. Prorenin and renin were positively correlated (Spearman correlation 0.51, <i>p</i> &lt; 0.001) with each other. Women and non-Hispanic blacks had lower prorenin and renin values at year 1. Diabetes, lower eGFR, and use of angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, statins, and diuretics were associated with higher levels. Prorenin and renin decreased by a mean of 2 and 5% per year, respectively. Non-Hispanic black race and eGFR &lt;30 mL/min/1.73 m<sup>2</sup> at year 1 predicted a steeper decrease in prorenin and renin over time. In addition, each increase in urinary sodium excretion by 2 SDs at year 1 increased prorenin and renin levels by 4 and 5% per year, respectively. <b><i>Discussion/Conclusions:</i></b> The cross-sectional clinical factors associated with prorenin and renin values were similar. Overall, both plasma prorenin and renin concentrations decreased over the years, particularly in those with severe CKD at study entry.
DOI: 10.5517/ccdc.csd.cc25hd36
title: CCDC 2010787: Experimental Crystal Structure Determination

description: Related Article: R. Diana, U. Caruso, L. Di Costanzo, F. Gentile, B. Panunzi|2021|Dyes Pigm.|184|108832|doi:10.1016/j.dyepig.2020.108832
DOI: 10.6084/m9.figshare.14236562
title: Seethaler et al., Biomarker validation, Supplementary Table 1.pdf

description: <b>Supplementary material for:</b><b>Seethaler et al., Biomarkers for assessment of intestinal permeability in clinical practice</b>
DOI: 10.6084/m9.figshare.14236562.v1
title: Seethaler et al., Biomarker validation, Supplementary Table 1.pdf

description: <b>Supplementary material for:</b><b>Seethaler et al., Biomarkers for assessment of intestinal permeability in clinical practice</b>
DOI: 10.5281/zenodo.4616433
title: NEMO 4.0 Basin test data

description: Test data from NEMO 4.0. Used for developing python tools to open NEMO raw netCDF output and make them readable by xgcm.
DOI: 10.48370/ofd/h3mty4
title: Wierzba trójpręcikowa (Salix triandra L.), 4368

description: Herbarium
DOI: 10.6084/m9.figshare.14236571
title: Supplementary Material for: High Prevalence of Small Intestinal Bacterial Overgrowth among Functional Dyspepsia Patients

description: <b><i>Background:</i></b> Small intestinal bacterial overgrowth (SIBO), characterized by either increased numbers or presence of colonic type bacteria in the small bowel has been previously described in functional dyspepsia (FD), based on breath testing. In this study, we aim to examine the prevalence of SIBO among FD patients using small bowel aspirate culture. <b><i>Methods:</i></b> We prospectively enrolled outpatients fulfilling Rome IV criteria for FD. Severity of symptoms was graded using the patient assessment of upper gastrointestinal symptom severity index (PAGI-SYM) questionnaire. Patients underwent upper gastrointestinal endoscopy and duodenal fluid was aspirated in sterile traps. SIBO was defined as ≥10<sup>3</sup> colony forming units/mL of duodenal aspirate and/or presence of colonic type bacteria. Patients undergoing gastroscopy due to gastroesophageal reflux symptoms – control group (CG) – and patients with irritable bowel syndrome (IBS) fulfilling Rome IV criteria were also recruited. <b><i>Results:</i></b> We enrolled 227 FD subjects, 30 CG, and 90 IBS patients. Among FD patients, 144 (63.4%), 64 (28.2%), and 19 (8.4%) had postprandial distress syndrome (PDS), epigastric pain syndrome (EPS), and overlapping PDS-EPS syndrome, respectively. SIBO prevalence was 20.8%, 12.5%, and 31.6% among PDS, EPS, and overlapping PDS-EPS FD subtypes, respectively. Overall, SIBO prevalence was significantly higher in FD (44/227 [19.4%]) compared to CG (1/30 [3.3%]) (<i>p</i> = 0.037) and similar to IBS (44/227 [19.4%] vs. 15/90 [16.7%], <i>p</i> = 0.63) subjects. SIBO presence was associated neither with total nor with any subscale score of the PAGI-SYM questionnaire. <b><i>Conclusion:</i></b> In a cohort of Greek FD patients, SIBO prevalence was similar to that of IBS subjects and higher compared to that of controls.
DOI: 10.6084/m9.figshare.14236571.v1
title: Supplementary Material for: High Prevalence of Small Intestinal Bacterial Overgrowth among Functional Dyspepsia Patients

description: <b><i>Background:</i></b> Small intestinal bacterial overgrowth (SIBO), characterized by either increased numbers or presence of colonic type bacteria in the small bowel has been previously described in functional dyspepsia (FD), based on breath testing. In this study, we aim to examine the prevalence of SIBO among FD patients using small bowel aspirate culture. <b><i>Methods:</i></b> We prospectively enrolled outpatients fulfilling Rome IV criteria for FD. Severity of symptoms was graded using the patient assessment of upper gastrointestinal symptom severity index (PAGI-SYM) questionnaire. Patients underwent upper gastrointestinal endoscopy and duodenal fluid was aspirated in sterile traps. SIBO was defined as ≥10<sup>3</sup> colony forming units/mL of duodenal aspirate and/or presence of colonic type bacteria. Patients undergoing gastroscopy due to gastroesophageal reflux symptoms – control group (CG) – and patients with irritable bowel syndrome (IBS) fulfilling Rome IV criteria were also recruited. <b><i>Results:</i></b> We enrolled 227 FD subjects, 30 CG, and 90 IBS patients. Among FD patients, 144 (63.4%), 64 (28.2%), and 19 (8.4%) had postprandial distress syndrome (PDS), epigastric pain syndrome (EPS), and overlapping PDS-EPS syndrome, respectively. SIBO prevalence was 20.8%, 12.5%, and 31.6% among PDS, EPS, and overlapping PDS-EPS FD subtypes, respectively. Overall, SIBO prevalence was significantly higher in FD (44/227 [19.4%]) compared to CG (1/30 [3.3%]) (<i>p</i> = 0.037) and similar to IBS (44/227 [19.4%] vs. 15/90 [16.7%], <i>p</i> = 0.63) subjects. SIBO presence was associated neither with total nor with any subscale score of the PAGI-SYM questionnaire. <b><i>Conclusion:</i></b> In a cohort of Greek FD patients, SIBO prevalence was similar to that of IBS subjects and higher compared to that of controls.
DOI: 10.6084/m9.figshare.14236547
title: Supplementary Material for: The Effect of Saffron Consumption on Liver Function: A Systematic Review and Meta-Analysis of Randomized Controlled Clinical Trials

description: <b><i>Background and Aims:</i></b> The present systematic review and meta-analysis of randomized controlled trials aimed to determine the effects of saffron supplementation on liver function tests among adults. <b><i>Methods:</i></b> Electronic databases including PubMed, ISI Web of Science, and Scopus were searched up to January 2021. The risk of bias in individual studies was assessed using the Cochrane Collaboration tool. The overall estimates and their 95% CIs were calculated using random-effects models. Egger’s test and Begg’s rank-correlation were run to assess the presence of publication bias. <i>p</i> &lt; 0.05 was considered statistically significant. <b><i>Results:</i></b> A total of 12 trials involving 608 participants were included in this systematic review and meta-analysis. Saffron supplementation had no significant effect on liver function tests including aspartate transaminase (AST) (weighted mean difference [WMD] = 0.23 U/L; 95% CI –2.22 to 2.69; <i>p</i> = 0.851; <i>I</i><sup>2</sup> = 74.0%), alanine aminotransferase (ALT) (WMD = –1.49 U/L; 95% CI –3.84 to 0.86; <i>p</i> = 0.213; <i>I</i><sup>2</sup> = 60.2%), and alkaline phosphatase (ALP) (WMD = –0.70 U/L; 95% CI –11.35 to 9.95; <i>p</i> = 0.898; <i>I</i><sup>2</sup> = 40.8%) compared to placebo. <b><i>Conclusion:</i></b> Based on what was discussed, it seems that saffron supplementation could not improve liver function tests including AST, ALT, and ALP among the adult population. Further clinical trials with larger sample size, longer duration, and higher doses of saffron should be conducted exclusively among patients with liver dysfunction to elucidate the beneficial role of saffron consumption on liver function.
DOI: 10.5281/zenodo.4615048
title: Tomographic data acquired by a combination of a grid scan and half-acquisition scans: Part 06

description: Tomographic data acquired by a combination of a grid scan and half-acquisition scans (offset center-of-rotation in respect to the grid as a whole) was used to demonstrate data-processing methods in the paper: "Data processing methods and data acquisition for samples larger than the field of view in parallel-beam tomography" Nghia T. Vo, Robert C. Atwood, M. Drakopoulos, and Thomas Connolley, https://doi.org/10.1364/OE.418448 To extract data, you firstly collect all the files together (There are 47 files uploaded to 24 zenodo sections: *Part01, *Part02, ...*Part24) and run "zip -F grid_scan_splitted.zip --out data.zip" to recreate dataset. Then you can unzip by running "unzip data.zip"
DOI: 10.5281/zenodo.4615047
title: Tomographic data acquired by a combination of a grid scan and half-acquisition scans: Part 06

description: Tomographic data acquired by a combination of a grid scan and half-acquisition scans (offset center-of-rotation in respect to the grid as a whole) was used to demonstrate data-processing methods in the paper: "Data processing methods and data acquisition for samples larger than the field of view in parallel-beam tomography" Nghia T. Vo, Robert C. Atwood, M. Drakopoulos, and Thomas Connolley, https://doi.org/10.1364/OE.418448 To extract data, you firstly collect all the files together (There are 47 files uploaded to 24 zenodo sections: *Part01, *Part02, ...*Part24) and run "zip -F grid_scan_splitted.zip --out data.zip" to recreate dataset. Then you can unzip by running "unzip data.zip"
DOI: 10.5281/zenodo.4615040
title: Tomographic data acquired by a combination of a grid scan and half-acquisition scans: Part 05

description: Tomographic data acquired by a combination of a grid scan and half-acquisition scans (offset center-of-rotation in respect to the grid as a whole) was used to demonstrate data-processing methods in the paper: "Data processing methods and data acquisition for samples larger than the field of view in parallel-beam tomography" Nghia T. Vo, Robert C. Atwood, M. Drakopoulos, and Thomas Connolley, https://doi.org/10.1364/OE.418448 To extract data, you firstly collect all the files together (There are 47 files uploaded to 24 zenodo sections: *Part01, *Part02, ...*Part24) and run "zip -F grid_scan_splitted.zip --out data.zip" to recreate dataset. Then you can unzip by running "unzip data.zip"
DOI: 10.5281/zenodo.4615039
title: Tomographic data acquired by a combination of a grid scan and half-acquisition scans: Part 05

description: Tomographic data acquired by a combination of a grid scan and half-acquisition scans (offset center-of-rotation in respect to the grid as a whole) was used to demonstrate data-processing methods in the paper: "Data processing methods and data acquisition for samples larger than the field of view in parallel-beam tomography" Nghia T. Vo, Robert C. Atwood, M. Drakopoulos, and Thomas Connolley, https://doi.org/10.1364/OE.418448 To extract data, you firstly collect all the files together (There are 47 files uploaded to 24 zenodo sections: *Part01, *Part02, ...*Part24) and run "zip -F grid_scan_splitted.zip --out data.zip" to recreate dataset. Then you can unzip by running "unzip data.zip"
DOI: 10.5281/zenodo.4615026
title: Tomographic data acquired by a combination of a grid scan and half-acquisition scans: Part 04

description: Tomographic data acquired by a combination of a grid scan and half-acquisition scans (offset center-of-rotation in respect to the grid as a whole) was used to demonstrate data-processing methods in the paper: "Data processing methods and data acquisition for samples larger than the field of view in parallel-beam tomography" Nghia T. Vo, Robert C. Atwood, M. Drakopoulos, and Thomas Connolley, https://doi.org/10.1364/OE.418448 To extract data, you firstly collect all the files together (There are 47 files uploaded to 24 zenodo sections: *Part01, *Part02, ...*Part24) and run "zip -F grid_scan_splitted.zip --out data.zip" to recreate dataset. Then you can unzip by running "unzip data.zip"
DOI: 10.5281/zenodo.4615016
title: Tomographic data acquired by a combination of a grid scan and half-acquisition scans: Part 03

description: Tomographic data acquired by a combination of a grid scan and half-acquisition scans (offset center-of-rotation in respect to the grid as a whole) was used to demonstrate data-processing methods in the paper: "Data processing methods and data acquisition for samples larger than the field of view in parallel-beam tomography" Nghia T. Vo, Robert C. Atwood, M. Drakopoulos, and Thomas Connolley, https://doi.org/10.1364/OE.418448 To extract data, you firstly collect all the files together (There are 47 files uploaded to 24 zenodo sections: *Part01, *Part02, ...*Part24) and run "zip -F grid_scan_splitted.zip --out data.zip" to recreate dataset. Then you can unzip by running "unzip data.zip"
DOI: 10.5281/zenodo.4615025
title: Tomographic data acquired by a combination of a grid scan and half-acquisition scans: Part 04

description: Tomographic data acquired by a combination of a grid scan and half-acquisition scans (offset center-of-rotation in respect to the grid as a whole) was used to demonstrate data-processing methods in the paper: "Data processing methods and data acquisition for samples larger than the field of view in parallel-beam tomography" Nghia T. Vo, Robert C. Atwood, M. Drakopoulos, and Thomas Connolley, https://doi.org/10.1364/OE.418448 To extract data, you firstly collect all the files together (There are 47 files uploaded to 24 zenodo sections: *Part01, *Part02, ...*Part24) and run "zip -F grid_scan_splitted.zip --out data.zip" to recreate dataset. Then you can unzip by running "unzip data.zip"
DOI: 10.5281/zenodo.4615015
title: Tomographic data acquired by a combination of a grid scan and half-acquisition scans: Part 03

description: Tomographic data acquired by a combination of a grid scan and half-acquisition scans (offset center-of-rotation in respect to the grid as a whole) was used to demonstrate data-processing methods in the paper: "Data processing methods and data acquisition for samples larger than the field of view in parallel-beam tomography" Nghia T. Vo, Robert C. Atwood, M. Drakopoulos, and Thomas Connolley, https://doi.org/10.1364/OE.418448 To extract data, you firstly collect all the files together (There are 47 files uploaded to 24 zenodo sections: *Part01, *Part02, ...*Part24) and run "zip -F grid_scan_splitted.zip --out data.zip" to recreate dataset. Then you can unzip by running "unzip data.zip"
DOI: 10.5281/zenodo.4615004
title: Tomographic data acquired by a combination of a grid scan and half-acquisition scans: Part 02

description: Tomographic data acquired by a combination of a grid scan and half-acquisition scans (offset center-of-rotation in respect to the grid as a whole) was used to demonstrate data-processing methods in the paper: "Data processing methods and data acquisition for samples larger than the field of view in parallel-beam tomography" Nghia T. Vo, Robert C. Atwood, M. Drakopoulos, and Thomas Connolley, https://doi.org/10.1364/OE.418448 To extract data, you firstly collect all the files together (There are 47 files uploaded to 24 zenodo sections: *Part01, *Part02, ...*Part24) and run "zip -F grid_scan_splitted.zip --out data.zip" to recreate dataset. Then you can unzip by running "unzip data.zip"
DOI: 10.5281/zenodo.4615003
title: Tomographic data acquired by a combination of a grid scan and half-acquisition scans: Part 02

description: Tomographic data acquired by a combination of a grid scan and half-acquisition scans (offset center-of-rotation in respect to the grid as a whole) was used to demonstrate data-processing methods in the paper: "Data processing methods and data acquisition for samples larger than the field of view in parallel-beam tomography" Nghia T. Vo, Robert C. Atwood, M. Drakopoulos, and Thomas Connolley, https://doi.org/10.1364/OE.418448 To extract data, you firstly collect all the files together (There are 47 files uploaded to 24 zenodo sections: *Part01, *Part02, ...*Part24) and run "zip -F grid_scan_splitted.zip --out data.zip" to recreate dataset. Then you can unzip by running "unzip data.zip"
DOI: 10.5281/zenodo.4615639
title: Tomographic data acquired by a combination of a grid scan and half-acquisition scans: Part 07

description: Tomographic data acquired by a combination of a grid scan and half-acquisition scans (offset center-of-rotation in respect to the grid as a whole) was used to demonstrate data-processing methods in the paper: "Data processing methods and data acquisition for samples larger than the field of view in parallel-beam tomography" Nghia T. Vo, Robert C. Atwood, M. Drakopoulos, and Thomas Connolley, https://doi.org/10.1364/OE.418448 To extract data, you firstly collect all the files together (There are 47 files uploaded to 24 zenodo sections: *Part01, *Part02, ...*Part24) and run "zip -F grid_scan_splitted.zip --out data.zip" to recreate dataset. Then you can unzip by running "unzip data.zip"
DOI: 10.5281/zenodo.4614789
title: Tomographic data acquired by a combination of a grid scan and half-acquisition scans: Part 01

description: Tomographic data acquired by a combination of a grid scan and half-acquisition scans (offset center-of-rotation in respect to the grid as a whole) was used to demonstrate data-processing methods in the paper: "Data processing methods and data acquisition for samples larger than the field of view in parallel-beam tomography" Nghia T. Vo, Robert C. Atwood, M. Drakopoulos, and Thomas Connolley, https://doi.org/10.1364/OE.418448 To extract data, you firstly collect all the files together (There are 47 files uploaded to 24 zenodo sections: *Part01, *Part02, ...*Part24) and run "zip -F grid_scan_splitted.zip --out data.zip" to recreate dataset. Then you can unzip by running "unzip data.zip"
DOI: 10.5281/zenodo.4615638
title: Tomographic data acquired by a combination of a grid scan and half-acquisition scans: Part 07

description: Tomographic data acquired by a combination of a grid scan and half-acquisition scans (offset center-of-rotation in respect to the grid as a whole) was used to demonstrate data-processing methods in the paper: "Data processing methods and data acquisition for samples larger than the field of view in parallel-beam tomography" Nghia T. Vo, Robert C. Atwood, M. Drakopoulos, and Thomas Connolley, https://doi.org/10.1364/OE.418448 To extract data, you firstly collect all the files together (There are 47 files uploaded to 24 zenodo sections: *Part01, *Part02, ...*Part24) and run "zip -F grid_scan_splitted.zip --out data.zip" to recreate dataset. Then you can unzip by running "unzip data.zip"
DOI: 10.5281/zenodo.4614788
title: Tomographic data acquired by a combination of a grid scan and half-acquisition scans: Part 01

description: Tomographic data acquired by a combination of a grid scan and half-acquisition scans (offset center-of-rotation in respect to the grid as a whole) was used to demonstrate data-processing methods in the paper: "Data processing methods and data acquisition for samples larger than the field of view in parallel-beam tomography" Nghia T. Vo, Robert C. Atwood, M. Drakopoulos, and Thomas Connolley, https://doi.org/10.1364/OE.418448 To extract data, you firstly collect all the files together (There are 47 files uploaded to 24 zenodo sections: *Part01, *Part02, ...*Part24) and run "zip -F grid_scan_splitted.zip --out data.zip" to recreate dataset. Then you can unzip by running "unzip data.zip"
DOI: 10.24378/exe.2644
title: Reducing NF-κB signalling nutritionally is associated with expedited recovery of skeletal muscle function after damage (dataset)

description: This is the dataset used for the Jameson et al. (2021) article "Reducing NF-κB signalling nutritionally is associated with expedited recovery of skeletal muscle function after damage" published in The Journal of Clinical Endocrinology & Metabolism.
description: Supplementary data S1