cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.5061/dryad.jq2bvq85k
title: Data from: Statin therapy in acute cardioembolic stroke with no guidance-based indication

description: Objective It is uncertain if patients with cardioembolic stroke and
 absence of a guidance-based indication for statin therapy should be
 administered a statin for prevention of subsequent vascular events. This
 study was performed to determine whether the statin therapy is beneficial
 to prevent major vascular events in this population. Methods Using a
 prospective multicenter stroke registry database, we identified acute
 cardioembolic stroke patients who were hospitalized between 2008 and 2015.
 Patients who had other established indications for statin therapy
 according to current guideline were excluded. Major vascular event was
 defined as a composite of stroke recurrence, myocardial infarction and
 vascular death. We performed frailty model analysis with the robust
 sandwich variance estimator using the stabilized inverse probability of
 treatment weighting method to estimate hazard ratios of statin therapy on
 outcomes. Results Of 6,124 cardioembolic stroke patients, 2,888 (male,
 44.6%; mean age, 75.3 years with 95% confidence interval 74.8-75.8) were
 eligible; and 1,863 (64.5%) were on statin therapy during hospitalization.
 After a median follow-up of 359 days, cumulative incidences of major
 vascular events were 9.3% in the statin users and 20.5% in the non-users
 (p &lt;0.001 by log-rank test). The adjusted hazard ratios of statin
 therapy was 0.39 (95% confidence interval, 0.31-0.48) for major vascular
 events; 0.81 (0.57-1.16) for stroke recurrence; 0.28 (0.21-0.36) for
 vascular death; and 0.53 (0.45-0.61) for all-cause death, respectively.
 Conclusion Starting statin during acute stage of ischemic stroke
 may reduce the risk of major vascular events, vascular death and all-cause
 death in cardioembolic stroke patients with no guidance-based indication
 for statin.
description: This retrospective observational study was based on a
 prospective, nationwide, multicenter, web-based acute stroke registry
 (Clinical Research Collaboration for Stroke in Korea, CRCS-K) of
 consecutive acute ischemic stroke or TIA patients admitted to 15 academic
 or regional stroke centers in Korea. Among a total of 30,656 patients
 registered in the CRCS-K registry database between April 2008 and March
 2015, 26,880 acute ischemic stroke or TIA patients were hospitalized at
 the participating centers within 7 days from their symptom onset. Among
 these patients, 6,124 patients were classified as CES according to a
 modified Trial of Org 10172 in Acute Stroke Treatment classification
 system.
DOI: 10.5061/dryad.931zcrjfv
title: Parentage analyses identify local dispersal events and sibling aggregations in a natural population of Millepora hydrocorals, a free-spawning marine invertebrate

description: Dispersal is a critical process for the persistence and productivity of
 marine populations. For many reef species, there is increasing evidence
 that local demography and self-recruitment have major consequences on
 their genetic diversity and adaptation to environmental change. Yet
 empirical data of dispersal patterns in reef-building species remain
 scarce. Here, we document the first genetic estimates of self-recruitment
 and dispersal distances in a free-spawning marine invertebrate, the
 hydrocoral Millepora platyphylla. Using twelve microsatellite
 markers, we gathered genotypic information from 3,160 georeferenced
 colonies collected over 9,000 m2 of a single reef in three
 adjacent habitats in Moorea, French Polynesia; the mid slope, upper slope,
 and back reef. Although the adult population was predominantly clonal (85%
 were clones), our parentage analysis revealed a moderate self-recruitment
 rate with 8 to 37% of sexual propagules produced locally. Assigned
 offspring often settled at less than 10 meters from their parents and
 dispersal events decrease with increasing geographic distance. There were
 no discrepancies between the dispersal distances of offspring assigned to
 parents belonging to clonal versus non-clonal
 genotypes. Inter-habitat dispersal events via cross-reef transport were
 also detected for sexual and asexual propagules. Sibship analysis showed
 that full siblings recruit together on the reef (more than 40% settled at
 &lt; 30 m), resulting in sibling aggregations. Our findings highlight
 the importance of self-recruitment together with clonality in stabilizing
 population dynamics, which may ultimately enhance local sustainability and
 resilience to disturbance.
DOI: 10.5061/dryad.w3r2280kw
title: Economic Models to Measure US-China Trade Volume

description: The purpose of the data/article is to measure the volume of import/export
 between the U.S. and China in light of the trade wars between the two
 countries. Specifically the paper uses seasonal ARIMA model and double
 index EST model.
DOI: 10.25338/b8rc9h
title: Survey data for: Planning and policymaking for TOD, transit, and AT in California cities

description: This in-progress two-year research project for the California Department
 of Transportation, through the National Center for Sustainable
 Transportation, is assessing planning and policymaking for
 transit-oriented development , transit, and active transport in California
 cities located in the state's four largest regions, the San Francisco
 Bay, Los Angeles, San Diego, and Sacramento areas. The dataset we provide
 here is an anonymous version of our survey results of city planning
 directors in these regions, conducted between April and July, 2019. We
 also supply the survey questions.
DOI: 10.5061/dryad.tht76hdvg
title: Data for manuscript: Extinction pulse at Eocene–Oligocene boundary drives diversification dynamics of the two Australian temperate floras

description: The diversification dynamics of the Australian temperate flora remains
 poorly understood. Here, we investigate whether differences in plant
 richness in the southwest Australian biodiversity hotspot (SWA) and
 southeast (SEA) regions of the Australian continent can be attributed to
 higher net diversification, more time for species accumulation, or both.
 We assembled dated molecular phylogenies for the 21 most species-rich
 flowering plant families found across mesic temperate Australia,
 encompassing both SWA and SEA regions, and applied a series of
 diversification models to investigate responses across different groups
 and time scales. We show that the high richness in SWA can be attributed
 to a higher net rate of lineage diversification and more time for species
 accumulation. Different pulses of diversification were retrieved in each
 region. A decrease in diversification rate across major flowering plant
 lineages at the Eocene–Oligocene boundary (c. 34 Ma) was
 witnessed in SEA but not in SW A.
description: Data was collected through online repositories and available
 studies.
DOI: 10.5061/dryad.z612jm67z
title: Influence of anthropogenic landscape modifications and infrastructure on the geological characteristics of liquefaction

description: Many large cities worldwide are built on natural and engineered geological
 materials that are highly susceptible to liquefaction and associated
 ground failure in earthquakes. Constitutive equations describing
 relationships between sediment geotechnical characteristics, seismological
 parameters, and liquefaction susceptibility of natural and engineered
 sediments are well established. What is less understood is the role of
 anthropogenic landscape modifications (e.g., river channel modifications,
 sediment engineering and re-distribution) and infrastructure (e.g.,
 buildings, buried infrastructure such as drainage systems) on the spatial
 distributions and severity of liquefaction and ground deformation. Here we
 use stratigraphic studies, ground penetrating radar (GPR), and analyses of
 high-resolution aerial photographs to evaluate surface and subsurface
 geological manifestations of recurrent liquefaction in
 anthropogenically-modified landscapes during the 2010-2011 Canterbury
 earthquake sequence in New Zealand. Engineered fill layers provided low
 density, high permeability traps that captured fluidized sediment and
 promoted the formation of a unique assemblage of liquefaction-induced
 sediment intrusions that differ from those preserved in proximal natural
 sediment. Subsurface drainage systems imparted significant influence on
 the location, size and orientations of liquefaction ejecta features.
 Sediments adjacent to engineered stream channels experienced large lateral
 strains that are unlikely to have occurred in the absence of channel
 modifications. Spatial variations in pre-Anthropocene topography and
 liquefaction-susceptible sediments exerted strong influence on the
 characteristics of liquefaction hazards, even in highly engineered
 environments. Collectively, these observations highlight important
 interactions between concomitant Anthropocene and pre-Anthropocene
 environments that should be carefully considered when interpreting the
 geologic effects of contemporary earthquakes and / or using
 pre-Anthropocene geological records to forecast future hazards.
description: The following supplementary files are included:
 - Figures S.1 - S.6 - Tables S.1 -
 S.3 - ST.1_Supplemental Text for Figure
 Captions - SCPT_1 Factual Geotechnical Report
 - SCPT_1 CPT data.xls - SCPT_1 Seismic
 data.xls - Porritt Park GPR lines
 (unannotated) - Avondale Park (AP) GPR lines
 (unannotated)
DOI: 10.5061/dryad.bnzs7h466
title: Data from: Study on characteristics of fire plume in building facade window under lateral blow

description: The overflow of the flame plume from the window is the main cause of the
 vertical spread of the fire on the facade of the building. This paper
 considers the geometry of the window by taking measures to prevent the
 flame from propagating along the vertical wall. In this paper, a
 residential building is taken as an example to evaluate the flame plume
 characteristics through experimental tests and numerical simulations. The
 objective of the present study is to study the flame plume characteristics
 under the air blow on the outer window side of the building. The
 theoretical equations of the flame tilt angle, non-dimensional temperature
 and non-dimensional velocity are derived. A series of experimental tests
 were carried out in a reduced-scale building model corresponding to the
 changes of lateral blow ventilation velocity. Reduced scale numerical
 simulations were conducted to verify the experiments. Results showed that
 the flame tilt angle increases with ventilation velocity increases.
 Meanwhile, the experimental results were compared with the reduced-scale
 tests and numerical simulations. These showed a good agreement between
 experimental results and numerical simulations. All these findings provide
 theoretical basis for building fire prevention outside window.
DOI: 10.5061/dryad.5x69p8d07
title: DNA methylation profiles suggest intergenerational transfer of maternal effects

description: The view of maternal effects (non-genetic maternal environmental influence
 on offspring phenotype) has changed from one of distracting complications
 in evolutionary genetics to an important evolutionary mechanism for
 improving offspring fitness. Recent studies have shown that maternal
 effects act as an adaptive mechanism to prepare offspring for stressful
 environments. Although research into the magnitude of maternal effects is
 abundant, the molecular mechanisms of maternal influences on offspring
 phenotypic variation are not fully understood. Despite recent work
 identifying DNA methylation as a potential mechanism of non-genetic
 inheritance, currently proposed links between DNA methylation and parental
 effects are indirect and primarily involve genomic imprinting. We combined
 a factorial breeding design and gene-targeted sequencing methods to assess
 inheritance of methylation during early life stages at 14 genes involved
 in growth, development, metabolism, stress response and immune function of
 Chinook salmon (Oncorhynchus tshawytscha). We found little evidence for
 additive or non-additive genetic effects acting on methylation levels
 during early development; however, we detected significant maternal
 effects. Consistent with conventional maternal effect data, maternal
 effects on methylation declined through development and were replaced with
 non-additive effects when offspring began exogenous feeding. We mapped
 methylation at individual CpG sites across the selected candidate genes to
 test for variation in site-specific methylation profiles and found
 significant maternal effects at selected CpG sites that also declined with
 development stage. While intergenerational inheritance of methylated DNA
 is controversial, we show that CpG-specific methylation may function as an
 underlying molecular mechanism for maternal effects, with important
 implications for offspring fitness.
DOI: 10.5061/dryad.kwh70rz04
title: Data from: A homozygous nonsense variant in LRIF1 associated with facioscapulohumeral muscular dystrophy

description: Objective: Facioscapulohumeral muscular dystrophy (FSHD) is a
 heterogenetic disorder predominantly characterized by progressive facial
 and scapular muscle weakness. FSHD patients either have a contraction of
 the D4Z4 repeat on chromosome 4q35 or mutations in D4Z4 chromatin
 modifiers SMCHD1 and DNMT3B, both causing D4Z4 chromatin relaxation and
 inappropriate expression of the D4Z4-encoded DUX4 gene in skeletal muscle.
 In this study we tested the hypothesis if LRIF1, a known SMCHD1 protein
 interactor, is a disease gene for idiopathic FSHD2.  Methods:
 Clinical examination of an idiopathic FSHD2 patient was combined with
 pathological muscle biopsy examination and with genetic, epigenetic and
 molecular studies. Results: A homozygous LRIF1 mutation was identified in
 a patient with a clinical phenotype consistent with FSHD. This mutation
 resulted in the absence of the long isoform of LRIF1 protein, D4Z4
 chromatin relaxation, and DUX4 and DUX4 target gene expression in
 myonuclei, all molecular and epigenetic hallmarks of FSHD. In concordance,
 LRIF1 was shown to bind to the D4Z4 repeat and knock down of the LRIF1
 long isoform in muscle cells results in DUX4 and DUX4 target gene
 expression. Conclusions: LRIF1 is a bona fide disease gene for FSHD2. This
 study further reinforces the unifying genetic mechanism which postulates
 that FSHD is caused by D4Z4 chromatin relaxation resulting in
 inappropriate DUX4 expression in skeletal muscle.
DOI: 10.5061/dryad.f7m0cfxrh
title: Data from: Activation of β-catenin signaling and its cross talk with estrogen and histone deacetylases in human uterine fibroids

description: Context: Uterine Fibroid (UF) is the most common benign tumor in
 myometrium (MM) of reproductive age women. However, mechanism underlying
 disease pathogenesis is largely unknown. Objective: To explore the link
 between nuclear β-catenin and UF phenotype and β-catenin cross-talk with
 estrogen and histone deacetylases (HDACs). Design protein/RNA levels of
 β-catenin (CTNNB1), its responsive markers [CyclinD1, c-Myc], Androgen
 receptor (AR), p27 and class-I HDACs were measured in matched UF/MM
 tissues or cell populations. Chemical inhibition/activation and genetic
 knockdown (KD) of CTNNB1 were performed and their effects on UF phenotype
 were measured. Anti-UF Effect of two HDAC inhibitors (HDACis) was
 evaluated. Main Outcome Measure: β-catenin nuclear translocation in
 response to β-catenin inhibition/activation, estrogen and HDACis in UF
 cells. Results: UF tissues/cells showed significantly higher expression of
 nuclear β-catenin, CyclinD1, C-Myc, and HDACs (1, 2, 3, 8) than MM.
 Estradiol induced β-catenin nuclear-translocation and consequently its
 responsive genes in both MM and UF cells, while Estrogen receptor
 antagonist reversed this induction effect. Treatment with β-catenin or
 HDAC inhibitors showed a dose dependent growth inhibition, while Wnt3a
 treatment increased proliferation compared to control. Chemical inhibition
 of β-catenin decreased CyclinD1 and c-Myc expression levels, while
 β-catenin activation increased same markers expression.  Genetic
 KD of CTNNB1 resulted in marked decrease in β-catenin, CyclinD1, C-Myc and
 AR expression. Treatment of UF cells with HDACis decreased nuclear
 β-catenin, CyclinD1 and C-Myc expression. Moreover, HDACis induced UF
 cells apoptosis and cell cycle arrest. Conclusion: β-catenin
 nuclear-translocation contributes to UF phenotype, β-catenin signaling is
 modulated by estradiol and HDAC activity.
DOI: 10.82294/dvn8tugst
title: Entrevistas semiestructuradas. Territorio: Caquetá. Sector: Educación. Año: 2025

description: A partir de un proceso de acompañamiento situado, se recopilaron testimonios por medio de entrevistas semiestructuradas durante el año 2025, las cuales indagaron sobre 4 categorías que describían la práctica en educación artística de docentes, cultores, sabedores de la enseñanza del arte, que hacían parte de los programas de formación en educación artística y cultural del sector Educación (educación formal) en el departamento de Caquetá.
DOI: 10.5061/dryad.6djh9w0x4
title: Data from: Allometric scaling laws linking biomass and rooting depth vary across ontogeny and functional groups in tropical dry forest lianas and trees

description: There are two theories about how allocation of metabolic products occurs.
 The allometric biomass partitioning theory (APT) suggests that all plants
 follow common allometric scaling rules. The optimal partitioning theory
 (OPT) predicts that plants allocate more biomass to the organ capturing
 the most limiting resource. We used whole-plant harvests of mature and
 juvenile tropical deciduous trees, evergreen trees, and lianas and model
 simulations to address the following knowledge gaps: 1) Do mature lianas
 comply with the APT scaling laws or do they invest less biomass in stems
 compared to trees? 2) Do juveniles follow the same allocation patterns as
 mature individuals? 3) Is either leaf phenology or life form a predictor
 of rooting depth? We found: 1) mature lianas followed the same allometric
 scaling laws as trees. 2) Juveniles and mature individuals do not follow
 the same allocation patterns. 3) Mature lianas had shallowest coarse roots
 and evergreen trees had the deepest. We demonstrate: 1) mature lianas
 invested proportionally similar biomass to stems as trees and not less, as
 expected. 2) Lianas were not deeper rooted than trees as had been
 previously proposed. 3) Evergreen trees had the deepest roots, which is
 necessary to maintain canopy during simulated dry seasons.
description: We harvested above and
 belowground 1-year-old, 2-year-old, and mature lianas and trees. We
 weighed all the dry biomass and measured the diameter and length of the
 stem and roots.
description: RootSumDimBase_mm = the sum of all the diameters of the roots
 measured at the base of each root. RootSumLength_cm =
 the sum od the length of all of the roots
 MaxStemLength_cm =  maximum rooting depth
 SLALeafWeight_g = the leaf weight from specific leaf are used to
 calculate total canopy area SLALeafArea_cm2 = the leaf
 area from specific leaf are used to calculate total canopy area
DOI: 10.6078/d12t2x
title: Ancestral male recombination in Drosophila albomicans produced geographically restricted neo-Y chromosome haplotypes varying in age and onset of decay

description: Male Drosophila typically have achiasmatic meiosis, and fusions between
 autosomes and the Y chromosome have repeatedly created
 non-recombining neo-Y chromosomes that degenerate. Intriguingly,
 Drosophila nasuta males recombine, but their close relative D. albomicans
 reverted back to achiasmy after evolving neo-sex chromosomes. Here we use
 genome-wide polymorphism data to reconstruct the complex evolutionary
 history of neo-sex chromosomes in D. albomicans and examine the effect of
 recombination and its cessation on the initiation of neo-Y decay.
 Population and phylogenomic analyses reveal three distinct neo-Y types
 that are geographically restricted. Due to ancestral recombination with
 the neo-X, overall nucleotide diversity on the neo-Y is similar to the
 neo-X but severely reduced within neo-Y types. Consistently, the neo-Y
 chromosomes fail to form a monophyletic clade in sliding window trees
 outside of the region proximal to the fusion. Based on tree topology
 changes, we inferred the recombination breakpoints that produced
 haplotypes specific to each neo-Y type. We show that recombination became
 suppressed at different time points for the different neo-Y haplotypes.
 Haplotype age correlates with onset of neo-Y decay, and older neo-Y
 haplotypes show more fixed gene disruption via frameshift indels and
 down-regulation of neo-Y alleles. Genes are downregulated independently on
 the different neo-Ys, but are depleted of testes-expressed genes across
 all haplotypes. This indicates that genes important for male function are
 initially shielded from degeneration. Our results offer a time course of
 the early progression of Y chromosome evolution, showing how the
 suppression of recombination, through the reversal to achiasmy in D.
 albomicans males, initiates the process of degeneration.
DOI: 10.25338/b8mk7k
title: Genital morphology and the mechanics of copulation in the millipede genus Pseudopolydesmus (Diplopoda: Polydesmida: Polydesmidae)

description: Mate choice, copulation, genital morphology, and sperm storage are not
 very well understood in millipedes. The use of three-dimensional x-ray
 computed tomography (µCT) provides new morphological data regarding
 millipede reproductive systems in both the female and male, including
 chitinous sclerites and membranes, muscles, glands, oviducts, and sperm
 conduits. Here we present a complete integrated account of the morphology
 and function of the female genital organs in the family Polydesmidae
 (Diplopoda: Polydesmida) using µCT, UV fluorescence imaging, and scanning
 electron microscopy. These data allow us to consider competing hypotheses
 regarding millipede vulva formation. We additionally present the
 morphology of copulatory interface in Pseudopolydesmus Attems, 1898 using
 images of a mating pair in copula and by simulating the interface of the
 organs using 3D models from µCT, allowing us to tentatively identify a
 lock-and-key-like mechanism. Finally, we use µCT to reveal the topology of
 the seminal canal in the gonopod of male Pseudopolydesmus, a topic that
 has remained unresolved for nearly 80 years.
description: Specimens were dehydrated successively in a series of 80%, 85%,
 90%, and finally 95% ethanol (unless already stored in 95% ethanol) with
 at least 2 hours in each stage. Specimens were stained for 24-48 hours in
 a 1% solution of iodine in 100% ethanol (after Metscher, 2009). The iodine
 stains soft tissues (Gignac <i>et al.</i>, 2016), increasing
 their contrast under x-ray imaging. Dehydrated and
 stained specimens were mounted in 95% ethanol in either a 0.5 mL or 1.0 mL
 microfuge tube depending on their size. Intact full body specimens were
 mounted head-first and gently wedged in place (to prevent movement during
 imaging) using a small layer of cotton. Body ring fragments were mounted
 between two cotton layers. 3D image acquisition was
 performed using an XRadia microXCT-200 housed in the Center for Molecular
 and Genomic Imaging at the University of California, Davis. Images were
 acquired using detectors with 4x or 10x magnification (producing images
 with 4.5 µm and 2.0 µm voxel resolution, respectively). Specifications for
 each scan are provided in the original publication. The 3D images were
 reconstructed as .txm files, which were converted to .tif stacks using
 Drishti Import (Limaye, 2012).
description: 3D image files (.txm) can be viewed using Amira/Aviso.
 Alternatively, the free program Drishti Import (Limaye, 2012) can be used
 to preview the stack and convert it to the Metaimage format (.mhd).
 Metaimage files can be viewed in the free program ITK-SNAP (Yushkevich
 <i>et al.</i>, 2006).