cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.5281/zenodo.11442132
title: Antibacterial Hydrogel Adhesives based on Bifunctional Telechelic Dendritic-Linear-Dendritic Block Copolymers

description: Antibiotic resistant pathogens have been declared by WHO as one of the major public health threats facing humanity.  For that reason, there is an urgent need for materials with inherent antibacterial activity able to replace the use of antibiotics, and in this context, hydrogels have emerged as a promising strategy. Herein, we introduce the next generation of cationic hydrogels with antibacterial activity and high versatility that can be cured on demand in less than twenty seconds by using Thiolene Click Chemistry (TEC) in aqueous conditions. The approach capitalizes on a two-component system: i) telechelic polyester based Dendritic-Linear-Dendritic (DLDs) block copolymers of different generations heterofunctionalized with allyl and ammonium groups, as well as ii) polyethylene glycol (PEG) crosslinkers functionalized with thiol groups. These hydrogels resulted in highly tunable materials where the antibacterial performance can be adjusted by modifying the crosslinking density. Off-stoichiometric hydrogels showed narrow antibacterial activity directed towards Gram-negative bacteria. The presence of pending allyls opens up many possibilities for functionalization with biologically interesting molecules.  As a proof-of-concept, hydrophilic cysteamine hydrochloride as well as N-hexyl-4-mercaptobutanamide, as an example of a thiol with a hydrophobic alkyl chain, generated three-component networks. In the case of cysteamine derivatives, a broader antibacterial activity was noted than the two-component networks, inhibiting also the growth of Gram-positive bacteria. Additionally, these systems presented high versatility, with storage modulus values ranging from 270 to 7024 Pa and different stability profiles ranging from 1 to 56 days in swelling experiments. Good biocompatibility towards skin cells as well as strong adhesion to multiple surfaces, place these hydrogels as interesting alternatives to conventional antibiotics.
description: Welcome to the data respository for the publication "Antibacterial Hydrogel Adhesives based on Bifunctional Telechelic Dendritic-Linear-Dendritic Block Copolymers" (doi.org/10.1021/jacs.4c03673).

All data was collected at the Division of Coating Technology, Department of Fibre and Polymer Technology, KTH Royal Institute of Technology, Stockholm, Sweden.

The data in this respository is organized in accordance to the figures in the publication and the supporting information. The chemical and hydrogel names in the files match those in the publication. All instruments,  parameters and conditions used to collect this data can be found in the publication's experimental section.

Please note that all data using decimal points (0.00) and that data in the .csv files is seperated with a comma (,).
DOI: 10.5281/zenodo.11442131
title: Antibacterial Hydrogel Adhesives based on Bifunctional Telechelic Dendritic-Linear-Dendritic Block Copolymers

description: Antibiotic resistant pathogens have been declared by WHO as one of the major public health threats facing humanity.  For that reason, there is an urgent need for materials with inherent antibacterial activity able to replace the use of antibiotics, and in this context, hydrogels have emerged as a promising strategy. Herein, we introduce the next generation of cationic hydrogels with antibacterial activity and high versatility that can be cured on demand in less than twenty seconds by using Thiolene Click Chemistry (TEC) in aqueous conditions. The approach capitalizes on a two-component system: i) telechelic polyester based Dendritic-Linear-Dendritic (DLDs) block copolymers of different generations heterofunctionalized with allyl and ammonium groups, as well as ii) polyethylene glycol (PEG) crosslinkers functionalized with thiol groups. These hydrogels resulted in highly tunable materials where the antibacterial performance can be adjusted by modifying the crosslinking density. Off-stoichiometric hydrogels showed narrow antibacterial activity directed towards Gram-negative bacteria. The presence of pending allyls opens up many possibilities for functionalization with biologically interesting molecules.  As a proof-of-concept, hydrophilic cysteamine hydrochloride as well as N-hexyl-4-mercaptobutanamide, as an example of a thiol with a hydrophobic alkyl chain, generated three-component networks. In the case of cysteamine derivatives, a broader antibacterial activity was noted than the two-component networks, inhibiting also the growth of Gram-positive bacteria. Additionally, these systems presented high versatility, with storage modulus values ranging from 270 to 7024 Pa and different stability profiles ranging from 1 to 56 days in swelling experiments. Good biocompatibility towards skin cells as well as strong adhesion to multiple surfaces, place these hydrogels as interesting alternatives to conventional antibiotics.
description: Welcome to the data respository for the publication "Antibacterial Hydrogel Adhesives based on Bifunctional Telechelic Dendritic-Linear-Dendritic Block Copolymers" (doi.org/10.1021/jacs.4c03673).

All data was collected at the Division of Coating Technology, Department of Fibre and Polymer Technology, KTH Royal Institute of Technology, Stockholm, Sweden.

The data in this respository is organized in accordance to the figures in the publication and the supporting information. The chemical and hydrogel names in the files match those in the publication. All instruments,  parameters and conditions used to collect this data can be found in the publication's experimental section.

Please note that all data using decimal points (0.00) and that data in the .csv files is seperated with a comma (,).
DOI: 10.15468/dl.pmaoyr
title: Occurrence Download

description: A dataset containing 8 species occurrences available in GBIF matching the query:
{
 "DatasetKey" : [
 "is (Table 1) Proportion of Toxoplasma gondii seropositive arctic foxes (Alopex lagopus) by age group and geographic area"
 ]
}

 The dataset includes 8 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0000583-150811131857512/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.q7adz8
title: Occurrence Download

description: A dataset containing 8 species occurrences available in GBIF matching the query:
{
 "DatasetKey" : [
 "is (Table 1) Proportion of Toxoplasma gondii seropositive arctic foxes (Alopex lagopus) by age group and geographic area"
 ]
}

 The dataset includes 8 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0000584-150316153013904/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.hn64zg
title: Occurrence Download

description: A dataset containing 8 species occurrences available in GBIF matching the query:
{
 "DatasetKey" : [
 "is (Table 1) Proportion of Toxoplasma gondii seropositive arctic foxes (Alopex lagopus) by age group and geographic area"
 ]
}

 The dataset includes 8 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0000584-150407101314760/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.xc3fhj
title: Occurrence Download

description: A dataset containing 167030810 species occurrences available in GBIF matching the query:
{
 "Country" : [
 "is United States of America"
 ]
}

 The dataset includes 167030810 records from 1358 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0000584-150422101436696/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.cm3ajq
title: Occurrence Download

description: A dataset containing 8 species occurrences available in GBIF matching the query:
{
 "DatasetKey" : [
 "is (Table 1) Proportion of Toxoplasma gondii seropositive arctic foxes (Alopex lagopus) by age group and geographic area"
 ]
}

 The dataset includes 8 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0000583-150221044754056/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.f6cnyp
title: Occurrence Download

description: A dataset containing 8 species occurrences available in GBIF matching the query:
{
 "DatasetKey" : [
 "is (Table 1) Proportion of Toxoplasma gondii seropositive arctic foxes (Alopex lagopus) by age group and geographic area"
 ]
}

 The dataset includes 8 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0000584-150811131857512/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.tcrvby
title: Occurrence Download

description: A dataset containing 8 species occurrences available in GBIF matching the query:
{
 "DatasetKey" : [
 "is (Table 1) Proportion of Toxoplasma gondii seropositive arctic foxes (Alopex lagopus) by age group and geographic area"
 ]
}

 The dataset includes 8 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0000585-150504100648427/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.nowgjl
title: Occurrence Download

description: A dataset containing 8 species occurrences available in GBIF matching the query:
{
 "DatasetKey" : [
 "is (Table 1) Proportion of Toxoplasma gondii seropositive arctic foxes (Alopex lagopus) by age group and geographic area"
 ]
}

 The dataset includes 8 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0000585-150615163101818/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.wj1ktj
title: Occurrence Download

description: A dataset containing 8 species occurrences available in GBIF matching the query:
{
 "DatasetKey" : [
 "is (Table 1) Proportion of Toxoplasma gondii seropositive arctic foxes (Alopex lagopus) by age group and geographic area"
 ]
}

 The dataset includes 8 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0000587-150827100048397/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.eziepf
title: Occurrence Download

description: A dataset containing 8 species occurrences available in GBIF matching the query:
{
 "DatasetKey" : [
 "is (Table 1) Proportion of Toxoplasma gondii seropositive arctic foxes (Alopex lagopus) by age group and geographic area"
 ]
}

 The dataset includes 8 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0000586-150221044754056/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.hlym1f
title: Occurrence Download

description: A dataset containing 8 species occurrences available in GBIF matching the query:
{
 "DatasetKey" : [
 "is (Table 1) Proportion of Toxoplasma gondii seropositive arctic foxes (Alopex lagopus) by age group and geographic area"
 ]
}

 The dataset includes 8 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0000587-150204170955391/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.ao7gww
title: Occurrence Download

description: A dataset containing 8 species occurrences available in GBIF matching the query:
{
 "DatasetKey" : [
 "is (Table 1) Proportion of Toxoplasma gondii seropositive arctic foxes (Alopex lagopus) by age group and geographic area"
 ]
}

 The dataset includes 8 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0000588-150311145101897/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.q13mym
title: Occurrence Download

description: A dataset containing 8 species occurrences available in GBIF matching the query:
{
 "DatasetKey" : [
 "is (Table 1) Proportion of Toxoplasma gondii seropositive arctic foxes (Alopex lagopus) by age group and geographic area"
 ]
}

 The dataset includes 8 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0000586-150811131857512/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.9djbnm
title: Occurrence Download

description: A dataset containing 8 species occurrences available in GBIF matching the query:
{
 "DatasetKey" : [
 "is (Table 1) Proportion of Toxoplasma gondii seropositive arctic foxes (Alopex lagopus) by age group and geographic area"
 ]
}

 The dataset includes 8 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0000586-150827100048397/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.37qua2
title: Occurrence Download

description: A dataset containing 60 species occurrences available in GBIF matching the query:
{
 "and" : [
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "TaxonKey is Evolvulus arbuscula Poir."
 ]
}

 The dataset includes 60 records from 13 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0074922-240506114902167/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.amhdjw
title: Occurrence Download

description: A dataset containing 8 species occurrences available in GBIF matching the query:
{
 "DatasetKey" : [
 "is (Table 1) Proportion of Toxoplasma gondii seropositive arctic foxes (Alopex lagopus) by age group and geographic area"
 ]
}

 The dataset includes 8 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0000589-150407101314760/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.gbyb7p
title: Occurrence Download

description: A dataset containing 8 species occurrences available in GBIF matching the query:
{
 "DatasetKey" : [
 "is (Table 1) Proportion of Toxoplasma gondii seropositive arctic foxes (Alopex lagopus) by age group and geographic area"
 ]
}

 The dataset includes 8 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0000589-150523225239109/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.sjxlrf
title: Occurrence Download

description: A dataset containing 8 species occurrences available in GBIF matching the query:
{
 "DatasetKey" : [
 "is (Table 1) Proportion of Toxoplasma gondii seropositive arctic foxes (Alopex lagopus) by age group and geographic area"
 ]
}

 The dataset includes 8 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0000589-150504100648427/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.6084/m9.figshare.29198880
title: Role of carbon dots as nanocarriers in drug delivery: current advancements, prospects, and implementations

description: Carbon dots (CDs) are recognized as outstanding nanocarriers for drug delivery owing to their superior biocompatibility, straightforward synthetic routes, and tunable surface properties. This review presents a comprehensive overview of recent developments in CDs within the context of drug delivery systems (DDSs) and their utilization as carriers for drug loading, stabilization, and delivery. It also describes functionalized CDs for therapeutic applications, including cancer, antimicrobial, and gene therapies. Key strategic issues such as toxicity, biodistribution, and manufacturability are thoroughly elaborated and critically evaluated to identify novel approaches to address crucial challenges. The promising potential of CDs to transform current drug delivery methods is driving researchers to undertake further biological investigations regarding the application of the CDs in clinical settings, as well as to explore future prospects of CDs within the biomedical field.
DOI: 10.6084/m9.figshare.29198880.v2
title: Role of carbon dots as nanocarriers in drug delivery: current advancements, prospects, and implementations

description: Carbon dots (CDs) are recognized as outstanding nanocarriers for drug delivery owing to their superior biocompatibility, straightforward synthetic routes, and tunable surface properties. This review presents a comprehensive overview of recent developments in CDs within the context of drug delivery systems (DDSs) and their utilization as carriers for drug loading, stabilization, and delivery. It also describes functionalized CDs for therapeutic applications, including cancer, antimicrobial, and gene therapies. Key strategic issues such as toxicity, biodistribution, and manufacturability are thoroughly elaborated and critically evaluated to identify novel approaches to address crucial challenges. The promising potential of CDs to transform current drug delivery methods is driving researchers to undertake further biological investigations regarding the application of the CDs in clinical settings, as well as to explore future prospects of CDs within the biomedical field.
DOI: 10.6084/m9.figshare.29198880.v1
title: Role of carbon dots as nanocarriers in drug delivery: current advancements, prospects, and implementations

description: Carbon dots (CDs) are recognized as outstanding nanocarriers for drug delivery owing to their superior biocompatibility, straightforward synthetic routes, and tunable surface properties. This review presents a comprehensive overview of recent developments in CDs within the context of drug delivery systems (DDSs) and their utilization as carriers for drug loading, stabilization, and delivery. It also describes functionalized CDs for therapeutic applications, including cancer, antimicrobial, and gene therapies. Key strategic issues such as toxicity, biodistribution, and manufacturability are thoroughly elaborated and critically evaluated to identify novel approaches to address crucial challenges. The promising potential of CDs to transform current drug delivery methods is driving researchers to undertake further biological investigations regarding the application of the CDs in clinical settings, as well as to explore future prospects of CDs within the biomedical field.
DOI: 10.6084/m9.figshare.29277920
title: Feasibility of switching between different autoinjector designs: positive insights from formative Comparative Use Human Factors studies

description: Users may switch drug-device products when transitioning to generic versions. For autoinjectors, such switches can involve user interface differences, particularly in the activation mechanism, requiring either a push-on-skin step or button activation. It is essential to demonstrate that the use of a generic product remains safe and effective. This article provides preliminary usability data on various autoinjector designs, focusing on generic drug-device combination products. Two formative Comparative Use Human Factors studies assessed the usability of a 3-step candidate generic button-activated autoinjector compared to RLD autoinjectors: study 1 compared it to a 4-step button-activated while study 2 compared it to a 2-step push-on-skin. In study 1, 80% of participants (12/15) performed similarly with both devices. The error rate for the 3-step candidate generic autoinjector was 20% (3/15), compared to 13.3% (2/15) for the 4-step. In study 2, 90% of participants (10/11) performed similarly with both devices, with a 9% (1/11) error rate for the 3-step candidate generic autoinjector and 0% for the 2-step. These studies offer preliminary evidence supporting the feasibility of switching between different autoinjector activation mechanisms without introducing new risks. The main driver of usability results appears to be user familiarity rather than design differences.
DOI: 10.6084/m9.figshare.29277920.v2
title: Feasibility of switching between different autoinjector designs: positive insights from formative Comparative Use Human Factors studies

description: Users may switch drug-device products when transitioning to generic versions. For autoinjectors, such switches can involve user interface differences, particularly in the activation mechanism, requiring either a push-on-skin step or button activation. It is essential to demonstrate that the use of a generic product remains safe and effective. This article provides preliminary usability data on various autoinjector designs, focusing on generic drug-device combination products. Two formative Comparative Use Human Factors studies assessed the usability of a 3-step candidate generic button-activated autoinjector compared to RLD autoinjectors: study 1 compared it to a 4-step button-activated while study 2 compared it to a 2-step push-on-skin. In study 1, 80% of participants (12/15) performed similarly with both devices. The error rate for the 3-step candidate generic autoinjector was 20% (3/15), compared to 13.3% (2/15) for the 4-step. In study 2, 90% of participants (10/11) performed similarly with both devices, with a 9% (1/11) error rate for the 3-step candidate generic autoinjector and 0% for the 2-step. These studies offer preliminary evidence supporting the feasibility of switching between different autoinjector activation mechanisms without introducing new risks. The main driver of usability results appears to be user familiarity rather than design differences.
DOI: 10.6084/m9.figshare.29277920.v1
title: Feasibility of switching between different autoinjector designs: positive insights from formative comparative use human factors studies

description: Users may switch drug-device products when transitioning to generic versions. For autoinjectors, such switches can involve user interface differences, particularly in the activation mechanism, requiring either a push-on-skin step or button activation. It is essential to demonstrate that the use of a generic product remains safe and effective. This article provides preliminary usability data on various autoinjector designs, focusing on generic drug-device combination products. Two formative Comparative Use Human Factors studies assessed the usability of a 3-step candidate generic button-activated autoinjector compared to RLD autoinjectors: study 1 compared it to a 4-step button-activated while study 2 compared it to a 2-step push-on-skin. In study 1, 80% of participants (12/15) performed similarly with both devices. The error rate for the 3-step candidate generic autoinjector was 20% (3/15), compared to 13.3% (2/15) for the 4-step. In study 2, 90% of participants (10/11) performed similarly with both devices, with a 9% (1/11) error rate for the 3-step candidate generic autoinjector and 0% for the 2-step. These studies offer preliminary evidence supporting the feasibility of switching between different autoinjector activation mechanisms without introducing new risks. The main driver of usability results appears to be user familiarity rather than design differences.