cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.20036418.v1
title: Production, intake, and feeding behavior of dairy goats fed alfalfa via grazing and cassava

description: ABSTRACT This study examined the replacement of maize and soybean meal with cassava chips and alfalfa grazing, respectively. Twelve lactating Anglo-Nubian goats were kept on a Panicum maximum cv. Tobiatã pasture. The experiment was laid out in a Latin square design in which the following diets were tested: ground maize + soybean meal, cassava chips + soybean meal, ground maize + alfalfa grazing, and cassava chips + alfalfa grazing. The evaluated variables were feed intake, daily weight gain, milk yield and composition, and feeding behavior of the goats as well as production costs. Cassava chips and grazed alfalfa influenced the intakes of dry matter, crude protein, neutral detergent fiber, and total digestible nutrients. However, milk yield, body weight, and body score did not change. There was no diet effect on the proportions of protein, solids-not-fat, somatic cell count, or urea nitrogen in the milk. Treatments influenced the levels of fat, lactose, and total solids in milk, with the highest fat levels achieved with diets containing alfalfa. Grazing, rumination, and idle times and time spent interacting with other goats were not influenced by diets. The evaluated feedstuffs improved feed efficiency and reduced production costs. Therefore, cassava chips and alfalfa can replace certain ingredients without impairing the production performance of goats, but rather improving the profit of the producer.
DOI: 10.17632/v73n4nnd2v.1
title: CrSBr_esr

description: Electron spin resonance data on a single crystal of CrSBr as function of the temperature and applied field direction.
DOI: 10.6084/m9.figshare.19785262.v1
title: Supplementary Material for: Conditioned medium from human uterine cervical stem cells regulates oxidative stress and angiogenesis of retinal pigment epithelial cells.

description: Introduction: Retinal homeostasis is essential to avoid retinal pigment epithelium (RPE) damage resulting in photoreceptor death and blindness. Mesenchymal stem cells-based cell therapy could contribute to the maintenance of the retinal homeostasis. We have explored the effect of human uterine cervical stem cells (hUCESCs) conditioned medium (hUCESC-CM) on RPE cells under oxidative stress condition. Methods: ARPE-19 cells were treated with hydrogen peroxide (H2O2) in presence or absence of hUCESC-CM. qRT-PCR and Western blot were used to evaluate the expression of oxidative stress (HO-1, GCLC and HSPB1) and vasculogenesis (VEGFA, PDGFA and PDGFB) related factors. Also, we assessed in vitro effects of hUCESC-CM on endothelial cells (HUVEC) tube formation. Results: mRNA expression of HO-1, GCLC, HSPB1, VEGFA, PDGFA and PDGFB were significantly increased in ARPE-19 cells treated with H2O2 + hUCESC-CM compared to cells treated with H2O2 only. Regarding the tube formation assay, HUVEC treated with supernatant from ARPE-19 cells treated with H2O2 + hUCESC-CM showed a significant increase in average vessel length, number of capillary-like junctions and average of vessels area compared with HUVEC treated with supernatant from ARPE-19 cells treated with H2O2 only. Conclusion: Our results show potential therapeutic effects of hUCESC-CM on RPE, such as protection from damage by oxidative stress, stimulation of detoxifying genes and a better vascularization.
DOI: 10.6084/m9.figshare.19785262
title: Supplementary Material for: Conditioned medium from human uterine cervical stem cells regulates oxidative stress and angiogenesis of retinal pigment epithelial cells.

description: Introduction: Retinal homeostasis is essential to avoid retinal pigment epithelium (RPE) damage resulting in photoreceptor death and blindness. Mesenchymal stem cells-based cell therapy could contribute to the maintenance of the retinal homeostasis. We have explored the effect of human uterine cervical stem cells (hUCESCs) conditioned medium (hUCESC-CM) on RPE cells under oxidative stress condition. Methods: ARPE-19 cells were treated with hydrogen peroxide (H2O2) in presence or absence of hUCESC-CM. qRT-PCR and Western blot were used to evaluate the expression of oxidative stress (HO-1, GCLC and HSPB1) and vasculogenesis (VEGFA, PDGFA and PDGFB) related factors. Also, we assessed in vitro effects of hUCESC-CM on endothelial cells (HUVEC) tube formation. Results: mRNA expression of HO-1, GCLC, HSPB1, VEGFA, PDGFA and PDGFB were significantly increased in ARPE-19 cells treated with H2O2 + hUCESC-CM compared to cells treated with H2O2 only. Regarding the tube formation assay, HUVEC treated with supernatant from ARPE-19 cells treated with H2O2 + hUCESC-CM showed a significant increase in average vessel length, number of capillary-like junctions and average of vessels area compared with HUVEC treated with supernatant from ARPE-19 cells treated with H2O2 only. Conclusion: Our results show potential therapeutic effects of hUCESC-CM on RPE, such as protection from damage by oxidative stress, stimulation of detoxifying genes and a better vascularization.
DOI: 10.6084/m9.figshare.20036423
title: Comparison of chemical composition, energy content, and digestibility of different sources of distillers corn oil and soybean oil for pigs

description: ABSTRACT The objective of this study was to determine and compare the chemical composition; oxidation indicators; ether extract (EE) digestibility; and digestible, metabolizable, and net energy (DE, ME, and NE, respectively) content of distillers corn oil (DCO) from Brazil (CBR) and the United States (CUS), with refined (RSB) and degummed soybean oil (DSB) from Brazil offered to pigs. Fifty crossbred barrows (23.1±3.4 kg body weight) were fed a corn-soybean meal basal diet, or diets composed of 90% basal diet and 10% of one of the four oil sources (CBR, CUS, RSB, or DSB). Pigs were fed an amount of their respective experimental diets equivalent to 2.8 times the maintenance DE requirement for 9 d (sequentially 7 d for adaptation and 2 d for partial collection of feces). Distillers corn oil from Brazil contained lower linoleic acid (47.4%) than CUS (53.9%), RSB (54.2%), and DSB (51.5%), but greater contents of oleic (32.1%) and palmitic (14.6%) acids compared to CUS (27.0 and 12.9%), RSB (22.9 and 11.2%), and DSB (23.5 and 11.2%). The moisture and unsaponifiable contents of CBR (0.17 and 1.64%) and CUS (0.20 and 1.64%) were similar, but greater than the values found for RSB (0.05 and 1.20%) and DSB (0.12 and 1.02%). The anisidine value, free fatty acid content, and acidity of DCO samples were higher than soybean oils. The peroxide value and thiobarbituric reactive substances content increased in the oil samples over time. The apparent total tract digestibility (ATTD) of gross energy and the DE, ME and NE values of the oils did not differ among oil sources and ranged from 87.8 to 91.5%, and from 8280 to 8630, 8139 to 8459, and 7162 to 7444 kcal/kg, respectively. The ATTD of EE was greater in RSB and DSB than for CBR, but similar to CUS. The DCO produced in Brazil is an excellent energy source for pigs, with DE, ME, and NE values similar to those of DCO from the US and soybean oils.
DOI: 10.6084/m9.figshare.20036423.v1
title: Comparison of chemical composition, energy content, and digestibility of different sources of distillers corn oil and soybean oil for pigs

description: ABSTRACT The objective of this study was to determine and compare the chemical composition; oxidation indicators; ether extract (EE) digestibility; and digestible, metabolizable, and net energy (DE, ME, and NE, respectively) content of distillers corn oil (DCO) from Brazil (CBR) and the United States (CUS), with refined (RSB) and degummed soybean oil (DSB) from Brazil offered to pigs. Fifty crossbred barrows (23.1±3.4 kg body weight) were fed a corn-soybean meal basal diet, or diets composed of 90% basal diet and 10% of one of the four oil sources (CBR, CUS, RSB, or DSB). Pigs were fed an amount of their respective experimental diets equivalent to 2.8 times the maintenance DE requirement for 9 d (sequentially 7 d for adaptation and 2 d for partial collection of feces). Distillers corn oil from Brazil contained lower linoleic acid (47.4%) than CUS (53.9%), RSB (54.2%), and DSB (51.5%), but greater contents of oleic (32.1%) and palmitic (14.6%) acids compared to CUS (27.0 and 12.9%), RSB (22.9 and 11.2%), and DSB (23.5 and 11.2%). The moisture and unsaponifiable contents of CBR (0.17 and 1.64%) and CUS (0.20 and 1.64%) were similar, but greater than the values found for RSB (0.05 and 1.20%) and DSB (0.12 and 1.02%). The anisidine value, free fatty acid content, and acidity of DCO samples were higher than soybean oils. The peroxide value and thiobarbituric reactive substances content increased in the oil samples over time. The apparent total tract digestibility (ATTD) of gross energy and the DE, ME and NE values of the oils did not differ among oil sources and ranged from 87.8 to 91.5%, and from 8280 to 8630, 8139 to 8459, and 7162 to 7444 kcal/kg, respectively. The ATTD of EE was greater in RSB and DSB than for CBR, but similar to CUS. The DCO produced in Brazil is an excellent energy source for pigs, with DE, ME, and NE values similar to those of DCO from the US and soybean oils.
DOI: 10.6084/m9.figshare.19786465
title: Supplementary Material for: Which Electronic Health Record System Should We Use? – A Systematic Review

description: The UK government had intended to introduce a comprehensive EHRs system in England by 2020. These EHRs would run across primary, secondary, and social care linking data in a single digital platform. This systematic review's objectives were to identify studies that compare EHRs in terms of direct comparison between systems and evaluate them using System and Software Quality Requirements and Evaluation (SQuaRE) ISO/IEC 25010. A systematic review was performed by searching EMBASE and Ovid MEDLINE databases between 1974 and April 2021. All original studies that appraised EHR systems and their providers were included. The main outcome measures were EHR system comparison and SQuaRE’s eight characteristics: functional suitability, performance efficiency, compatibility, usability, reliability, security, maintainability, and portability. A total of 724 studies were identified using the search criteria. After review of titles and abstracts, this was filtered down to 40 studies as per exclusion and inclusion criteria set out in our study selection. Seven studies compared more than one EHR. The following number of studies looked at the various aspects of the SQuaRE respectively. Nineteen studies addressed functional suitability, n=18 performance efficiency, n=12 compatibility, n=25 usability, n=6 reliability, n=2 security, n=16 maintainability, and n=13 portability. Epic was the most studied EHR system and one of the most implemented vendors in the USA market, and one of the top ten in UK. It is difficult to assess which is the most advantageous EHR system currently available when looking at them in accordance with SQuaRE’s eight characteristics for software evaluation.
DOI: 10.6084/m9.figshare.20036430
title: Medication possession ratio in postmenopausal osteoporotic patients: a cross sectional study

description: Abstract Osteoporosis is a chronic disease of bone that increases risk of low-trauma fracture. Chronic treatment may lead to lower adherence with medication. The current study aims are to determine adherence rate of antiosteoporotic medication by Medication Possession Ratio. Data has been collected from outpatient settings registering cases of postmenopausal osteoporotic women taking medications for an average duration of one year in Karachi. These patients were classified in lower, middle, and affluent socioeconomic classes. Collected data were analyzed by the standardized formula of Medication Possession Ratio and SPSS. Average Medication Possession Ratio ≥80% achieved by Risedronate Brands in the middle class (80.28%±4.41), the affluent class (82.50%±5.09), Raloxifen Brands in affluent class (93.62%±1.57), Gonadotropics in the middle class (81.36%±6.02), affluent class (91.09%±2.05), Alendronate Brands in affluent class (85.42%±5.46). Average Medication Possession Ratio is &lt;80% with all antiosteoporotic medication in the lower class, while the average Medication Possession Ratio of Calcium and Vitamin D is ≥80% in all groups except lower class. Adherence rate was significantly higher among Alendronate group compare to Risedronate (p=0.044). Medication Possession Ratio is greater than 80% among all classes of low-cost antiosteoporotic medications. In addition, patients on once weekly oral medications are more adherent and compliant compare to oral daily or intranasal medications.
DOI: 10.6084/m9.figshare.20036430.v1
title: Medication possession ratio in postmenopausal osteoporotic patients: a cross sectional study

description: Abstract Osteoporosis is a chronic disease of bone that increases risk of low-trauma fracture. Chronic treatment may lead to lower adherence with medication. The current study aims are to determine adherence rate of antiosteoporotic medication by Medication Possession Ratio. Data has been collected from outpatient settings registering cases of postmenopausal osteoporotic women taking medications for an average duration of one year in Karachi. These patients were classified in lower, middle, and affluent socioeconomic classes. Collected data were analyzed by the standardized formula of Medication Possession Ratio and SPSS. Average Medication Possession Ratio ≥80% achieved by Risedronate Brands in the middle class (80.28%±4.41), the affluent class (82.50%±5.09), Raloxifen Brands in affluent class (93.62%±1.57), Gonadotropics in the middle class (81.36%±6.02), affluent class (91.09%±2.05), Alendronate Brands in affluent class (85.42%±5.46). Average Medication Possession Ratio is &lt;80% with all antiosteoporotic medication in the lower class, while the average Medication Possession Ratio of Calcium and Vitamin D is ≥80% in all groups except lower class. Adherence rate was significantly higher among Alendronate group compare to Risedronate (p=0.044). Medication Possession Ratio is greater than 80% among all classes of low-cost antiosteoporotic medications. In addition, patients on once weekly oral medications are more adherent and compliant compare to oral daily or intranasal medications.
DOI: 10.21227/6m88-7d42
title: Elderly Core Nursing Set (ENCS) - Functional Profile of Older Adults

description: Healthcare systems are capable of collecting a significant number of patient health-related parameters. Analyzing them to find the reasons that cause a given disease is challenging. Feature Selection techniques have been used to address this issue---reducing these parameters to a smaller set with the most "determinant" information. However, existing proposals usually focus on classification problems---aimed to detect whether a person is or is not suffering from an illness or from a finite set of illnesses. However, there are many situations in which health professionals need a numerical assessment to quantify the severity of an illness, thus dealing with a regression problem instead. Proposals using Feature Selection here are very limited. This paper examines several Feature Selection techniques to gauge their applicability to the regression-type problems, comparing these techniques by applying them to a real-life scenario on the functional profiles of older adults. Data from 829 functional profiles assessments in 49 residential homes were used in this study. The number of features was reduced from 31 to 25---with a \edit{correlation between inputs and outputs} of 0.99 according to the $R^2$ score and a Mean Square Error (MSE) of 0.11---or to 14 features---with a \edit{correlation} of 0.98 and MSE of 5.73.
DOI: 10.6084/m9.figshare.20036435.v1
title: Natural and synthetic pigments in sorghum-based diets for laying hens

description: ABSTRACT. The objective of this work was to evaluate the supplementation of yellow natural pigment levels based on Marigold Flower extract (2%) and yellow synthetic pigment (Carophyll Yellow 10%) in sorghum-based rations for commercial laying hens and their influence on bird performance and egg quality. A completely randomized design was adopted with 5 treatments, 6 replicates, and 5 laying hens in each repetition. The treatments evaluated were: Sorghum based diet without supplementation with pigmentant - Negative Control; 150 g t-1 of Yellow Natural Pigment feed; 300 g t-1 of yellow natural pigment feed; 450 g t-1 of yellow natural pigment feed; 25 g t-1 of yellow industrial pigment feed. The Tukey test was applied at 5% for the analysis of the variables of performance and quality of the eggs. The variables related to external and internal egg quality and poultry yield performance did not present significant results (p &gt; 0.05). Only the variable color of the yolk obtained significance (p &lt; 0.01), with an increase according to the number of pigments included in the diet. Sorghum can be used together supplementation of natural and synthetic pigments in the diet to improve yolk pigmentation. It is recommended to include 450g t-1 of natural marigold flower pigment feed (2%) in sorghum-based diets for better pigmentation of the yolk in place of 25 g t-1 of yellow synthetic pigmented, by improving the color of the yolk and not interfering in the productive performance of the laying hens and the quality of the eggs.
DOI: 10.6084/m9.figshare.20036435
title: Natural and synthetic pigments in sorghum-based diets for laying hens

description: ABSTRACT. The objective of this work was to evaluate the supplementation of yellow natural pigment levels based on Marigold Flower extract (2%) and yellow synthetic pigment (Carophyll Yellow 10%) in sorghum-based rations for commercial laying hens and their influence on bird performance and egg quality. A completely randomized design was adopted with 5 treatments, 6 replicates, and 5 laying hens in each repetition. The treatments evaluated were: Sorghum based diet without supplementation with pigmentant - Negative Control; 150 g t-1 of Yellow Natural Pigment feed; 300 g t-1 of yellow natural pigment feed; 450 g t-1 of yellow natural pigment feed; 25 g t-1 of yellow industrial pigment feed. The Tukey test was applied at 5% for the analysis of the variables of performance and quality of the eggs. The variables related to external and internal egg quality and poultry yield performance did not present significant results (p &gt; 0.05). Only the variable color of the yolk obtained significance (p &lt; 0.01), with an increase according to the number of pigments included in the diet. Sorghum can be used together supplementation of natural and synthetic pigments in the diet to improve yolk pigmentation. It is recommended to include 450g t-1 of natural marigold flower pigment feed (2%) in sorghum-based diets for better pigmentation of the yolk in place of 25 g t-1 of yellow synthetic pigmented, by improving the color of the yolk and not interfering in the productive performance of the laying hens and the quality of the eggs.
DOI: 10.5281/zenodo.6546550
title: Peri-implantation mouse embryos

description: 3D data volumes of developing mouse embryos. The dataset consists of:<br> 1. Cell nuclei data acquired with the confocal microscope. Voxel size: 0.207×0.207×1 µm or 0.23.23×0.23×1 µm<br> 2. Cell plasma membrane data acquired with the light-sheet microscope. Annotated nuclei volumes are stored in the 'Nuclei' directory. It contains two subdirectories 'train' and 'test', which were used for training a semantic segmentation network to predict the foreground pixels. There are 22 training and 13 validation stacks in the 'train' and 'test' directories respectively. Annotated plasma membrane volumes can be find inside the 'Membrane' directory. It contains two subdirectories 'train' and 'val', which were used for training a semantic segmentation network to predict the cell membranes. There are 5 training and 1 validation stacks in the 'train' and 'val' directories respectively. The data are saved as HDF5 files. Each HDF5 file contains the following datasets:<br> - `raw` - input image<br> - `label` - ground truth instance segmentation
DOI: 10.5281/zenodo.6546549
title: Peri-implantation mouse embryos

description: 3D data volumes of developing mouse embryos. The dataset consists of:<br> 1. Cell nuclei data acquired with the confocal microscope. Voxel size: 0.207×0.207×1 µm or 0.23.23×0.23×1 µm<br> 2. Cell plasma membrane data acquired with the light-sheet microscope. Annotated nuclei volumes are stored in the 'Nuclei' directory. It contains two subdirectories 'train' and 'test', which were used for training a semantic segmentation network to predict the foreground pixels. There are 22 training and 13 validation stacks in the 'train' and 'test' directories respectively. Annotated plasma membrane volumes can be find inside the 'Membrane' directory. It contains two subdirectories 'train' and 'val', which were used for training a semantic segmentation network to predict the cell membranes. There are 5 training and 1 validation stacks in the 'train' and 'val' directories respectively. The data are saved as HDF5 files. Each HDF5 file contains the following datasets:<br> - `raw` - input image<br> - `label` - ground truth instance segmentation
DOI: 10.5281/zenodo.6626561
title: Magnetic Soft Robotic Bladder for Assisted Urination

description: The poor contractility of the detrusor muscle in underactive bladders (UABs) fails to increase the pressure inside the UAB, leading to strenuous and incomplete urination. However, existing therapeutic strategies by modulating/repairing detrusor muscles, e.g., neurostimulation and regenerative medicine, still have low efficacy and/or adverse effects. Here, we present an implantable magnetic soft robotic bladder (MRB) that can directly apply mechanical compression to the UAB to assist urination. Composed of a biocompatible elastomer composite with optimized magnetic domains, the MRB enables on-demand contraction of the UAB when actuated by magnetic fields. A representative MRB for an UAB in a porcine model is demonstrated and MRB-assisted urination is validated by in situ computed tomography imaging after 14-day implantation. The urodynamic tests show a series of successful urination with a high pressure increase and fast urine flow. Our work paves the way for developing MRB to assist urination for humans with UABs.
DOI: 10.6084/m9.figshare.20036494.v1
title: In natura residues from peach palm heart industry for ruminant feed

description: ABSTRACT. Palm heart processing generates a large amount of residues like leaves, sheath and stems that have potential for ruminant feeding. This study aimed to evaluate the effect of in natura peach palm heart (Bactris gasipaes Khunt.) residues on performance, dry matter (DM) digestibility and intake of ruminants. External sheath was the most suitable residue for sheep, cattle and buffaloes feeding, although sheep presented rejection of 43.5 g kg-1. Thereby, assays of apparent and in vitro dry matter digestibility were done under four feeding treatments, which were the exclusive peach palm sheath, and that one mixed with residues of banana and rice, besides citrus pulp. The experiment was carried out under randomized complete design, with five replications. Greater DM intake (p &lt; 0.05) were observed in animals fed with peach palm sheath mixed with rice (1.12 kg day-1) and mixed with citrus pulp (0.91 kg day-1), however there were no difference among treatments regarding the sheep final weight (p &gt; 0.05). Cattle and buffaloes accept different types of peach palm residues, unlike sheep that present a low rejecting for them. Citrus pulp and rice residue raise the roughage quality. Peach palm residues can be an alternative roughage source to feed ruminants.