cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.14457/cu.the.2017.316
title: Mathematical models for treatment time of pathogenic infection in blood after antibiotics administration

description: The objective in this thesis is to create a mathematical model to predict the period of time needed to clear out the pathogens from the bloodstream after the patient receives certain antibiotics. The result will lead to the time where the drug administration can be terminated. This research is to compute the densities of bacteria and malaria in bloodstream at any given time and to compare this level with the actual results of the patient’s blood sampling, which was sent to the laboratory for investigation. The laboratory process of the blood sampling will usually take more than 2-3 days to culture and to calculate the density of pathogens. However, the prediction of treatment duration by using our mathematical model can get the results within few seconds. Therefore, the numerical results can be done faster by entering some certain parameters and running the mathematical program. The research method consists of the formulation of the death rates of bacteria and malaria in the mathematical forms under our assumptions. We assume that the independent variable is the plasma drug concentration and other parameters, based on the probabilistic theory, the relative velocity, the binding mechanism between drug molecules and pathogens by the blood convection, the structure and properties of antibiotics including bacteria and malaria. The dependent variable is the density of pathogens. The results from this research are consistent with the actual clinical data by comparing with the patient pathogen density graph.
DOI: 10.13145/bacdive125143.20191129.4.1
title: Streptomyces sp.

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.14457/cu.the.2017.317
title: Bioactive peptide derived from trypsin hydrolysis of unicellular cyanobacterium synechococcus sp.

description: A free radicals can promote denaturing reactions in many cellular components, which create oxidative stress and it results to damage in body tissue. The free radicals can causing many diseases including heart diseases, Alzheimer, inflammation and cancer. This research aimed to investigate the effect of bioactive peptides derived from Synechococcus sp. cultured for 21 days on antioxidant, anti-inflammation and anticancer activities. The Synechococcus sp. protein hydrolysate was prepared by trypsin digest and purified by ultrafiltration with molecular weight cut off membranes of 10, 5 and 3 kDa. The MW &lt;3 kDa fraction showed the highest NO, ABTS and DPPH radical scavenging activities with IC50 values of 34.51±9.8 µg protein/mL, IC50 11.54±0.3 µg protein/mL and IC50 13.63±0.15 µg protein/mL, respectively. The F2 fraction from gel filtration chromatography showed the strongest NO and ABTS radical scavenging activities with IC50 values of 7.68±0.64 µg protein/mL and 9.74±0.2 µg protein/mL, respectively. The F2 was purified by RP-HPLC to yield four fractions. The 30 – 40 min sub-fraction (F2-4) was selected for further analysis by mass spectroscopy. Five isolated peptides with amino acid sequences of AILQSYSAGKTK; 1,265.69 Da, ALNKTHLIQTK; 1,265.74 Da, LLVHAPVK; 875.55 Da, IPDAHPVK; 875.48 Da and VVVLRDGAVQQLGTPR; 1,706.97 Da were identified. The F2-4 had higher DPPH and NO radical scavenging activity compared to the synthetic peptide. Moreover, AILQSYSAGKTK had the highest ABTS radical scavenging activity. Furthermore, the F2 fraction protected oxidation-induced DNA damage in pBR322, pKS and pUC19 cells. F2 fraction was selected to study anti-inflammatory and anticancer properties. Anti-inflammatory effect, F2 fraction showed no cytotoxicity toward RAW264.7 macrophage cells. RT-PCR and qRT-PCR results showed that F2 reduced gene expression of pro-inflammatory cytokines iNOS, TNF-α, COX-1, COX-2 and IL-6. For anticancer activity, F2 fraction showed high anticancer activities in the human colon cancer cells (SW620) according to cytotoxic activity (MTT assay), with IC50 values of 106.58±21.46 µg protein/mL. The F2 fraction activated the apoptotic pathway in SW620 cells after treatment for 24, 48 and 72 hours. The highest activities of caspases 3, 8 and 9 were observed after treatment for 72 hours. These findings suggested that unicellular cyanobacterium Synechococcus sp. may be used to develop for natural anti-inflammation and natural anticancer drugs.
DOI: 10.13145/bacdive125144.20191129.4.1
title: Streptomyces sp.

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.13145/bacdive125145.20191129.4.1
title: Streptomyces sp.

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.14457/cu.the.2017.318
title: FeCu/SiO2 catalysts prepared by autocombustion method for fischer-tropsch synthesis

description: The purpose of this study was to prepare iron-based catalysts supported on silica by autocombustion method for directly using for Fischer-Tropsch synthesis (FTS) without a reduction step. The effect of different citric acid (CA):iron nitrate (N) molar ratios (CA:N), acid types and SiO2 supports on the FTS performance of catalysts were investigated. The CA:N had an important influence on the formation of iron active phases (FexC) and FTS activity. Increasing the CA:N molar ratios up to 0.1 increased CO conversion of catalyst to 86.5%, which was then decreased markedly at higher CA:N molar ratios. An excess of CA resulted in carbon residues covering the catalyst surface and declined FTS activity. The optimal catalyst (CA:N molar ratio = 0.1) achieved the highest CO conversion when compared with other autocombustion catalysts as well as reference catalyst prepared by impregnation method, followed by a reduction step. More interestingly, iron-based FTS catalysts need induction duration at the initial stage of FTS reaction even after reduction, because metallic iron species need time to be transformed to FexC. But here, even if without reduction, FexC was formed directly by autocombustion and induction period was eliminated during FTS reaction. The catalyst prepared using CA and Q-50 type of SiO2 gave a maximum CO conversion when compared with other catalysts. The autocombustion method had the advantage to synthesize more efficient catalysts without a reduction step for FTS.
DOI: 10.13145/bacdive125146.20191129.4.1
title: Streptomyces sp.

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.14457/cu.the.2017.319
title: Cuckoo search and enhanced artificial bee colony heuristic methods for vehicle routing problem with backhaul and time window constraints

description: The vehicle routing problem with backhauls and time windows (VRPBTW) aims to find a feasible vehicle route that minimizes the total traveling distance while imposing capacity, backhaul, and time-window constraints. In this dissertation, a mathematical model of VRPBTW is introduced to obtain an optimal solution. The heuristics, namely the nearest urgent candidate (NUC), which applies the urgency priority and candidate techniques, and the nearest neighbor with roulette wheel selection (NNRW) which is a combination of a roulette wheel selection method and the improved nearest neighbor heuristic, are also presented to solve this problem. Moreover, two metaheuristic methods are presented to obtain the optimal or near optimal solutions. The first is a cuckoo search (CS) algorithm, which is applied to this problem for the first time. The second is the enhanced artificial bee colony (EABC) algorithm which uses a forbidden list, the sequential search for onlookers, and the combination of neighborhood search techniques. The computational results indicate that proposed algorithms yield good performance in terms of solution quality, especially EABC. It obtained 33 ties or new best known solutions out of 45 instances comparing with the best known solutions found in the literature. Hence, the proposed algorithms are the effective ways to solve the VRPBTW.
DOI: 10.13145/bacdive125147.20191129.4.1
title: Streptomyces sp.

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.13145/bacdive125148.20191129.4.1
title: Streptomyces sp.

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.14457/cu.the.2017.320
title: Intracellular trafficking of different shaped oxidized carbon nanoparticles

description: Oxidized carbon nanospheres (OCSs) and graphene oxide sheets (GOShs) were prepared by oxidation of graphite. Oxidized carbon nanotubes (OCTs) was synthesized from single-walled carbon nanotubes. All three shapes of oxidized carbon nanoparticles (OCNs) were used for investigation of their intracellular trafficking in human embryonic kidney cells (HEK293T), mouse macrophage cells (RAW264.7) and human liver cancer cells (HepG2). The results revealed all three shapes of OCNs were internalized into through HEK293T and RAW264.7 cells without endosomal trapping, including localization of all the three OCNs in HEK293T’s lysosome. In case of RAW264.7 cells, OCTs and GOShs were localized in lysosomes, only OCSs can escape from degradation in RAW264.7‘s lysosome. In case of HepG2 cells, the three shapes of OCNs were internalized into the cells through endocytosis, OCSs, OCTs and GOShs were localized in endosome and lysosome. Furthermore, the all three shapes of OCNs were found in golgi apparatus in HEK293T and HepG2 cells. In case of RAW264.7 cells, OCSs, OCTs and GOShs were localized in endoplasmic reticulum and golgi apparatus. In addition, comparison of different shaped OCNs revealed that OCSs was the fastest cellular internalization, OCTs was moderate and GOShs was the slowest cellular internalization. Hence, oxidized carbon nanoparticles had great potential be applied in biological and biomedical applications, including drug delivery system. Especially, OCSs was capable of the fastest cellular internalization and evasion of lysosomal degradation.
DOI: 10.13145/bacdive125149.20191129.4.1
title: Streptomyces sp.

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.14457/cu.the.2017.321
title: Synthesis of thiofuranosides by dehydrative glycosylation in micellar media

description: Green and aqueous-based dehydrative glycosylation of thiofuranosides in micellar media was developed. The thiofuranosides are useful as precursors for carbohydrate synthesis, biological active molecules, and bio-surfactants. Dodecylbenzenesulfonic acid (DBSA), a commercially available Brønsted acid-surfactant, was employed to increase solubility of substrates and enhance rate of the glycosylation. Herein, we report the dehydrative glycosylation of furanosides and pyranosides with aliphatic, aromatic, and heterocyclic thiols in aqueous media to afford the thiofuranosides. Microwave irradiation led to improved yields and shorter reaction times. Other reaction parameters such as temperature and the amount of acid used were also optimized. Aliphatic and aromatic thiofuranosides were prepared from lactol precursors in moderate yields (24–72%) when using 100 mol% DBSA. Noteworthy, the open-chain dithioacetal which is a common by-product from the dehydrative glycosylation was not detected under these reaction conditions. Moreover, the methodology was simple and convenient to set up without the requirement for anhydrous conditions.
DOI: 10.13145/bacdive125150.20191129.4.1
title: Streptomyces sp.

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.14457/cu.the.2017.322
title: Pulmonary lesion texture classification from endobronchialultrasonogram using texture analysis

description: This research aims to develop a method to help distinguish the appearance of pulmonary lesions from a high-frequency sound (Endobronchial Ultrasound—EBUS) image. According to medical information, the appearance of smooth or rough texture of a lesion can significantly indicate that it is malignant or benign. In this study, the features that are used in the classification are divided into 3 groups: group 1 consists of 22 standard features, group 2 consists of the proposed features extracted from the weighted sum of the upper and lower GLCM which consists 12 features, and group 3 is the combination of group 1 and group 2. Not all the features in each group are used in the classification, only the best features are selected from each groups using three feature selection techniques: forward selection, backward selection, and genetic selection. After the best features are selected, they are entered into eight different classifiers for the classification. The overall process of the classification consists of preprocessing, window slicing, feature extraction, feature selection, and classification. The sample input consists of 89 lesion images where 55 of them are identified by the doctor as malignant and 34 of them are identified as benign. The classification results show that the highest accuracy rate of 86.517% can be obtained by using features from group 3 with genetic selection and support vector machine.
DOI: 10.13145/bacdive125151.20191129.4.1
title: Streptomyces sp.

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.13145/bacdive125152.20191129.4.1
title: Streptomyces sp.

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.14457/cu.the.2017.323
title: Characterization of aroma-active volatile compounds in tom yum soup by gas chromatography-mass spectrometry combined with sensory evaluation techniques

description: Gas chromatography-mass spectrometry/olfactometry coupled with headspace-solid phase microextraction (HS-SPME-GC-O/MS) was applied for the characterization of volatile compounds in Tom Yum soup and its individual ingredients including lemongrass, kaffir lime leaf, chili, fish sauce and lime juice. Using HS-SPME with a 50/30 µm DVB/CAR/PDMS fiber and an extraction temperature of 40 °C for 50 min, along with an HP-5MS capillary column programmed from 50 to 200 °C at 3 °C/min and an MS electron impact ionization at -70 eV, 101 peaks in the HS-SPME-GC-MS chromatogram of Tom Yum soup were detected, and 96 volatile compounds were identified including alcohols, aldehydes, esters, ethers, and terpenes. These findings are based on the comparison of MS spectra with the NIST library as well as experimental and literature retention index data. In comparison with the volatile compound profiles of each individual ingredient of Tom Yum soup (both before and after cooking), five extra volatile compounds including p-mentha-3,8-diene, α-cyclocitral, iso-isopulegol, p-mentha-1,5-dien-8-ol and decyl acetate were found after the cooking process, possibly due to chemical reactions (such as cyclization) among the compounds in the mixed ingredients. Furthermore, eighteen aroma compounds that contribute to the impressive aroma of Tom Yum soup were detected and described. Especially, the seven dominant aroma compounds found were β-citral, geranial, β-linalool, geraniol, nerol, 3-(methylthio)propanal and 2-isobutyl-3-methoxypyrazine. The first four aromas detected in Tom Yum soup are from the lemongrass, kaffir lime leaf, and lime juice; the last three aroma compounds are from lemongrass, fish sauce and chili, respectively.
DOI: 10.13145/bacdive125153.20191129.4.1
title: Streptomyces sp.

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.13145/bacdive125154.20191129.4.1
title: Streptomyces sp.

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.14457/cu.the.2017.324
title: Antibacterial agents from Dracaena cochinchinensis (Lour.) S.C.Chen and Eleutherine americana (Aubl.) Merr. Ex K. Heyne

description: Fifteen compounds including two new anthraquinones (118-119), two naturally occurring new compounds (116-117) and eleven known compounds were successfully isolated from the CH2Cl2 extracts of Dracaena cochinchinensis and Eleutherine americana i.e. dihydrochalcones (5 and 23), pterostilbene (27), homoisoflavanones (15 and 82-84), naphthalenes (85 and 116), pyranonaphthoquinone (86) and anthraquinones (99-100 and 117-119). Among isolated compounds, (+)-eleutherin (86) was the most potent antibacterial agent against Propionibacterium acnes KCCM 41747, Staphylococcus aureus ATCC 25923, Streptococcus sobrinus KCCM 11898, Streptococcus mutans ATCC 25175 and Salmonella typhi ATCC 422 with inhibition zones of 14.7 to 18.0 mm and MIC values of 0.24 to 7.8 µM. Compound 86 showed bacteriostatic effect against P. acnes while bactericidal agent was observed by this compound against other tested bacteria. The combination of chloramphenicol and 86 demonstrated synergistic effect against all tested bacteria. Moreover, anti-allergic activity of nine compounds on the release of β-hexosaminidase in rat basophil leukemia (RBL-2H3) cells by calcium ionophore A23178-induced stimulation were investigated. Loureirin B (5) showed the strongest activity followed by 23 and 27 with IC50 values of 7.8, 15.8 and 17.5 µM, respectively. For anticancer activity, 86 suppressed the growth of HeLa, HCT116 and HepG2 cancer cell lines with IC50 values of 0.3, 4.6 and 6.7 µM, respectively. Compound 86 displayed twice more toxic than positive control (5-fluorourasil) against HeLa cells. The suppression against the cell was also shown by 23 and 27 with IC50 value of 1.4 µM.
DOI: 10.13145/bacdive125155.20191129.4.1
title: Streptomyces sp.

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.14457/cu.the.2017.325
title: Catalytic hydrogenation of carbon dioxide for hydrocarbon synthesis

description: Catalytic hydrogenation can turn CO2 into hydrocarbon fuel. The development of the catalysts for CO2 hydrogenation has become important since the catalysts are critical for selective production of more higher hydrocarbons for practical application. In this work, the titania supported monometallic and bimetallic Fe-M (M = Co and Cu) catalysts were synthesized and tested for CO2 hydrogenation at 573 K and 1.1 MPa. Among the monometallic catalysts (Fe, Co and Cu/TiO2), only Fe/TiO2 catalyst exhibited some selectivity to higher hydrocarbons, while Co/TiO2 and Cu/TiO2 catalysts were highly selective only to CH4 and CO, respectively. The addition of a small amount of a second metal M (M= Co, Cu) to Fe at M/(M + Fe) = 0.10 atom atom-1 showed the synergetic promotion on the CO2 conversion and the space-time yields (STY) of hydrocarbon products. Characterization by temperature-programmed desorption (TPD) and diffuse reflectance infrared Fourier transform spectroscopy (DRIFTS) showed that the presence of K promoter significantly decreased the adsorption of H2, which suppressed the CH4 formation. On the other hand, La addition could promote the moderately adsorbed CO2 species (mainly monodentate carbonate species), which led to the enhanced C5-C7 selectivity. The simultaneous use of La and K promoters can tailor the H and C coverage on the catalyst surface, which plays an important role in altering product distribution in CO2 hydrogenation. Thus, incorporation of K and La as promoter can further improve the catalyst activity and product selectivity to higher hydrocarbons, indicating that the promoted Fe-based bimetallic catalysts are promising for CO2 hydrogenation to higher hydrocarbons.
DOI: 10.13145/bacdive125156.20191129.4.1
title: Streptomyces sp.

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.13145/bacdive125157.20191129.4.1
title: Streptomyces sp.

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.14457/cu.the.2017.326
title: Design and synthesis of selenium nanoparticles to overcome multiple drug resistance of cancer cells

description: The objective of this research is to synthesize selenium nanoparticles (SeNPs) stabilized by chitosan as a drug carrier for delivery doxorubicin to overcome drug-resistant in cancer cells. One important mechanism of multidrug resistance (MDR) includes decreased drug influx and increased drug efflux, leading to insufficient drug concentration to kill cancer cells. Therefore, to overcome MDR by increasing cellular uptake, the surface of SeNP was functionalized to provide 3 structural features: (i) a positive charge to improve their solubility, (ii) gallic acid, a hydrophobic molecule to enhance biocompatibility and (iii) folic acid, a targeting molecule to target cancer cells and enhance cellular uptake. The cytotoxicity of the DOX-SeNPs@TMC-FA was evaluated and found to enhance the activity of DOX by approximately 10-fold, resulting in decreased IC50 values compared to free DOX, while it showed less toxic in normal cells (WI-38). SeNPs@TMC-FA were taken up by cells, with cellular uptake increased further by folate receptor-mediated endocytosis, to overcome multidrug resistance. In addition, the DOX release profiles showed a pH dependence, which exhibited a faster release of DOX at pH 5.3 than at pH 7.4. The cumulative release amount of DOX at pH 5.3 was 54.1% within 2 h and 95.5% at 6 h, whereas the release rate at pH 7.4 was 12.3% in 2 h and 42.2% for 6 h. Mechanistic studies suggested that DOX-SeNPs@TMC-FA induced cell death through the apoptosis pathway by involvement of caspase-3 and PARP proteins. Hence, the results demonstrated that SeNPs@TMC-FA, has potential to develop as targeted carrier for overcoming drug resistance cells.
DOI: 10.13145/bacdive125158.20191129.4.1
title: Streptomyces sp.

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.