cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.23259360
title: Bullous lesions following phototherapy in a newborn

description: ABSTRACT A male infant presented with progressive jaundice immediately after birth. Fecal acholia and choluria associated with extensive bullous skin lesions in his trunk, abdomen, and upper and lower limbs developed during phototherapy. Several diagnostic hypotheses were presented, including neonatal porphyria, hemochromatosis, Alagille syndrome, and neonatal lupus. A 24-hour urine sample for the dosage of urinary porphyrins was collected, showing high results (1823.6µg in 100mL). At 50 days of life, fluorescence spectroscopy using a Wood’s lamp revealed simultaneous bright red fluorescence of urine-stained diapers and sample blood. A definitive diagnosis of congenital erythropoietic porphyria was made following identification of a mutation of the uroporphyrinogen synthetases III gene on genetic testing. The patient was subsequently maintained in a low light environment since then, resulting in improvement of the lesions. Congenital erythropoietic porphyria is a disease of the group of porphyrias that presents shortly after birth with blistering occurring in regions exposed to the sun or other ultraviolet light. Atrophic scars, mutilated fingers, and bright red fluorescence of the urine and teeth may also be observed. There is no specific treatment, and prophylaxis comprising a total avoidance of sunlight is generally recommended. A high degree of suspicion is required for diagnosis. An early diagnosis can lead to less damage. Here, we present the case of a newborn with congenital erythropoietic porphyria diagnosed after presenting with bullous lesions secondary to phototherapy.
DOI: 10.6084/m9.figshare.23259360.v1
title: Bullous lesions following phototherapy in a newborn

description: ABSTRACT A male infant presented with progressive jaundice immediately after birth. Fecal acholia and choluria associated with extensive bullous skin lesions in his trunk, abdomen, and upper and lower limbs developed during phototherapy. Several diagnostic hypotheses were presented, including neonatal porphyria, hemochromatosis, Alagille syndrome, and neonatal lupus. A 24-hour urine sample for the dosage of urinary porphyrins was collected, showing high results (1823.6µg in 100mL). At 50 days of life, fluorescence spectroscopy using a Wood’s lamp revealed simultaneous bright red fluorescence of urine-stained diapers and sample blood. A definitive diagnosis of congenital erythropoietic porphyria was made following identification of a mutation of the uroporphyrinogen synthetases III gene on genetic testing. The patient was subsequently maintained in a low light environment since then, resulting in improvement of the lesions. Congenital erythropoietic porphyria is a disease of the group of porphyrias that presents shortly after birth with blistering occurring in regions exposed to the sun or other ultraviolet light. Atrophic scars, mutilated fingers, and bright red fluorescence of the urine and teeth may also be observed. There is no specific treatment, and prophylaxis comprising a total avoidance of sunlight is generally recommended. A high degree of suspicion is required for diagnosis. An early diagnosis can lead to less damage. Here, we present the case of a newborn with congenital erythropoietic porphyria diagnosed after presenting with bullous lesions secondary to phototherapy.
DOI: 10.6084/m9.figshare.21843732.v1
title: Cerebellar associative learning underlies skilled reach adaptation

description: Source data for Calame, Becker, Person 2023
DOI: 10.6084/m9.figshare.21843732
title: Cerebellar associative learning underlies skilled reach adaptation

description: Source data for Calame, Becker, Person 2023
DOI: 10.6084/m9.figshare.23259363
title: DRUG DESIGN AGAINST COVID-19: A REMOTE TEACHING EXPERIENCE IN PHARMACEUTICAL CHEMISTRY

description: Infront of with the difficulties faced in making a new drug available to the population, it is essential to seek ways to simplify the process. In silico methodologies are alternatives to benchtop experiments, being frequently used due to their speed and low cost. The present study aimed to formulate a theoretical-practical activity in the Pharmaceutical Chemistry course, where students applied their knowledge of structural modeling and molecular docking to propose bioactive compounds against molecular targets of the SARS CoV-2 virus. The class was divided, and each group presented a drug candidate, the precursors being natural molecules. In total, seven derivatives were designed and tested against different macromolecules, and then an in silico prediction of their physicochemical characteristics was performed. The docking results were positive for all derivatives, in terms of binding energy, mainly GEND with -9.0 kcal mol-1. In addition, the prototypes exhibited good interactions with the amino acids of the respective targets, mainly KAED, QUED and GEND, in addition to presenting adequate physicochemical properties for meeting the Lipinski restrictions. Therefore, this study presented at least three potential inhibitors of SARS-CoV-2, showing the importance of using computational tools in drug design and development, as well as in teaching practice.
DOI: 10.6084/m9.figshare.23259363.v1
title: DRUG DESIGN AGAINST COVID-19: A REMOTE TEACHING EXPERIENCE IN PHARMACEUTICAL CHEMISTRY

description: Infront of with the difficulties faced in making a new drug available to the population, it is essential to seek ways to simplify the process. In silico methodologies are alternatives to benchtop experiments, being frequently used due to their speed and low cost. The present study aimed to formulate a theoretical-practical activity in the Pharmaceutical Chemistry course, where students applied their knowledge of structural modeling and molecular docking to propose bioactive compounds against molecular targets of the SARS CoV-2 virus. The class was divided, and each group presented a drug candidate, the precursors being natural molecules. In total, seven derivatives were designed and tested against different macromolecules, and then an in silico prediction of their physicochemical characteristics was performed. The docking results were positive for all derivatives, in terms of binding energy, mainly GEND with -9.0 kcal mol-1. In addition, the prototypes exhibited good interactions with the amino acids of the respective targets, mainly KAED, QUED and GEND, in addition to presenting adequate physicochemical properties for meeting the Lipinski restrictions. Therefore, this study presented at least three potential inhibitors of SARS-CoV-2, showing the importance of using computational tools in drug design and development, as well as in teaching practice.
DOI: 10.6084/m9.figshare.23259366
title: Validation of the Brazilian Portuguese version of the Quick Inventory of Depressive Symptomatology and Self-Report (QIDS-SR16) for the Brazilian population

description: Abstract Objectives To evaluate the psychometric properties of the Quick Inventory of Depressive Symptomatology (QID-SR16), a self-report instrument based on the Diagnostic and Statistical Manual of Mental Disorders, 4th edition (DSM-IV) criteria that assesses the severity of depression symptoms, in the Brazilian population. Methods Participants were 4,400 Brazilians over the age of 15 years recruited for an online survey assessing depressive symptoms during the early phase of the coronavirus disease 2019 (COVID-19) pandemic in Brazil. The internal consistency, construct validity, and convergent and discriminant validity of the QIDS-SR16 were evaluated. Results The model tested was considered an adequate fit to the data (comparative fit index [CFI] = 0.947, Tucker-Lewis index [TLI] = 0.927, and root-mean-square error of approximation [RMSEA] = 0.051) and its internal consistency was good, with a Cronbach’s alpha of 0.71 and an average item correlation of 0.23. The correlations between the total QIDS-SR16 score and the total scores of the Patient Health Questionnaire (PHQ-9) instruments (r = 0.67, p &lt; 0.001), the Posttraumatic Symptoms Checklist (PCL-5) (r = 0.61, p &lt; 0.001), and the Patient-Reported Outcomes Measurement Information System (PROMIS) (r = 0.60, p &lt; 0.001) indicate good concurrent and convergent validity. Conclusion The QIDS-SR16 has robust psychometric properties in terms of its internal consistency, construct validity, and convergent and discriminant validity. The Portuguese version of the QIDS-SR16 is an adequate instrument for assessment of depressive symptoms in the context of an online survey.
DOI: 10.6084/m9.figshare.23259366.v1
title: Validation of the Brazilian Portuguese version of the Quick Inventory of Depressive Symptomatology and Self-Report (QIDS-SR16) for the Brazilian population

description: Abstract Objectives To evaluate the psychometric properties of the Quick Inventory of Depressive Symptomatology (QID-SR16), a self-report instrument based on the Diagnostic and Statistical Manual of Mental Disorders, 4th edition (DSM-IV) criteria that assesses the severity of depression symptoms, in the Brazilian population. Methods Participants were 4,400 Brazilians over the age of 15 years recruited for an online survey assessing depressive symptoms during the early phase of the coronavirus disease 2019 (COVID-19) pandemic in Brazil. The internal consistency, construct validity, and convergent and discriminant validity of the QIDS-SR16 were evaluated. Results The model tested was considered an adequate fit to the data (comparative fit index [CFI] = 0.947, Tucker-Lewis index [TLI] = 0.927, and root-mean-square error of approximation [RMSEA] = 0.051) and its internal consistency was good, with a Cronbach’s alpha of 0.71 and an average item correlation of 0.23. The correlations between the total QIDS-SR16 score and the total scores of the Patient Health Questionnaire (PHQ-9) instruments (r = 0.67, p &lt; 0.001), the Posttraumatic Symptoms Checklist (PCL-5) (r = 0.61, p &lt; 0.001), and the Patient-Reported Outcomes Measurement Information System (PROMIS) (r = 0.60, p &lt; 0.001) indicate good concurrent and convergent validity. Conclusion The QIDS-SR16 has robust psychometric properties in terms of its internal consistency, construct validity, and convergent and discriminant validity. The Portuguese version of the QIDS-SR16 is an adequate instrument for assessment of depressive symptoms in the context of an online survey.
DOI: 10.6084/m9.figshare.23259368
title: Association of moderate and vigorous physical activity and relative muscle strength with neck circumference: a cross-sectional analysis of the Study of Health in Pomerode (SHIP-Brazil)

description: ABSTRACT Objective Neck circumference is a simple anthropometric measurement that may be linked to chronic diseases, physical activity, and muscle strength. We sought to verify the association of moderate and vigorous physical activity levels and relative muscle strength with neck circumference in a community in southern Brazil. Methods We cross-sectionally analyzed data from 2,488 participants (51% women), aged 20-79 years old from the Study of Health in Pomerode (SHIP-Brazil) conducted in Pomerode, Santa Catarina, Brazil. Increased neck circumference was defined with cutoff points of &gt;39cm for men and &gt;35cm for women. The independent variables were the level of moderate and vigorous physical activity using the short International Physical Activity Questionnaire, and relative muscle strength using the handgrip test and body mass. Univariate and multiple Poisson regression models were used to determine the association between variables (p≤0.05). Results The prevalence of increased neck circumference was 48.2% (60.4% in men, 39.6% in women) and was associated with low relative muscle strength (PR=1.26, 95%CI: 1.17-1.35) in men, insufficient moderate and vigorous physical activity levels (PR=1.23, 95%CI: 1.14-1.32), and relative muscle strength (PR=1.73, 95%CI: 1.61-1.87) in women. After adjusting for covariates, no significant associations were observed between insufficient moderate and vigorous physical activity levels in men (PR=1.02, 95%CI: 0.95-1.07). Conclusion Increased neck circumference seems to be an important predictor of low moderate and vigorous physical activity and relative strength loss in adults, and more pronounced in women.
DOI: 10.6084/m9.figshare.23259368.v1
title: Association of moderate and vigorous physical activity and relative muscle strength with neck circumference: a cross-sectional analysis of the Study of Health in Pomerode (SHIP-Brazil)

description: ABSTRACT Objective Neck circumference is a simple anthropometric measurement that may be linked to chronic diseases, physical activity, and muscle strength. We sought to verify the association of moderate and vigorous physical activity levels and relative muscle strength with neck circumference in a community in southern Brazil. Methods We cross-sectionally analyzed data from 2,488 participants (51% women), aged 20-79 years old from the Study of Health in Pomerode (SHIP-Brazil) conducted in Pomerode, Santa Catarina, Brazil. Increased neck circumference was defined with cutoff points of &gt;39cm for men and &gt;35cm for women. The independent variables were the level of moderate and vigorous physical activity using the short International Physical Activity Questionnaire, and relative muscle strength using the handgrip test and body mass. Univariate and multiple Poisson regression models were used to determine the association between variables (p≤0.05). Results The prevalence of increased neck circumference was 48.2% (60.4% in men, 39.6% in women) and was associated with low relative muscle strength (PR=1.26, 95%CI: 1.17-1.35) in men, insufficient moderate and vigorous physical activity levels (PR=1.23, 95%CI: 1.14-1.32), and relative muscle strength (PR=1.73, 95%CI: 1.61-1.87) in women. After adjusting for covariates, no significant associations were observed between insufficient moderate and vigorous physical activity levels in men (PR=1.02, 95%CI: 0.95-1.07). Conclusion Increased neck circumference seems to be an important predictor of low moderate and vigorous physical activity and relative strength loss in adults, and more pronounced in women.
DOI: 10.6084/m9.figshare.23259369
title: BRS Progresso and BRS Rendeira - new cassava cultivars with tolerance to post-harvest deterioration

description: Abstract BRS Rendeira and BRS Progresso are cassava (Manihot esculenta Crantz) cultivars with tolerance to post-harvest deterioration and high mean yields of fresh root (31.1 and 27.9 t ha-1) and starch (8.9 and 8.1 t ha-1) in annual production cycles. Both new varieties are recommended for the flour and starch industry.
DOI: 10.6084/m9.figshare.23259369.v1
title: BRS Progresso and BRS Rendeira - new cassava cultivars with tolerance to post-harvest deterioration

description: Abstract BRS Rendeira and BRS Progresso are cassava (Manihot esculenta Crantz) cultivars with tolerance to post-harvest deterioration and high mean yields of fresh root (31.1 and 27.9 t ha-1) and starch (8.9 and 8.1 t ha-1) in annual production cycles. Both new varieties are recommended for the flour and starch industry.
DOI: 10.6084/m9.figshare.23259372
title: In sickness and in health: labor in the production of medicines

description: Abstract This article analyzes the perception of workers about the working environment in pharmaceutical industries based on a qualitative study composed of semi-structured interviews with workers in the sector. In an antagonistic position to the national scenario of deindustrialization and unemployment, the production of medicines continues to rise, in terms of both billing and job opening, even in the face of recent economic and health crises. To understand the production model of the pharmaceutical industry and its impacts on the lives of people working in the sector, ten workers from two national manufacturers of generic medicines were interviewed located in the Agroindustrial District of Anápolis, in Goias (Brazil). As a result, we observed that the studied industries are configured according to sophisticated forms of control and intensification of production, which triggers a work environment that can degrade physical and mental health.
DOI: 10.6084/m9.figshare.23259372.v1
title: In sickness and in health: labor in the production of medicines

description: Abstract This article analyzes the perception of workers about the working environment in pharmaceutical industries based on a qualitative study composed of semi-structured interviews with workers in the sector. In an antagonistic position to the national scenario of deindustrialization and unemployment, the production of medicines continues to rise, in terms of both billing and job opening, even in the face of recent economic and health crises. To understand the production model of the pharmaceutical industry and its impacts on the lives of people working in the sector, ten workers from two national manufacturers of generic medicines were interviewed located in the Agroindustrial District of Anápolis, in Goias (Brazil). As a result, we observed that the studied industries are configured according to sophisticated forms of control and intensification of production, which triggers a work environment that can degrade physical and mental health.
DOI: 10.6084/m9.figshare.22829153.v1
title: Magnetic control of self-assembly and disassembly in organic materials

description: Magnetic control of disassembly (TEM data)
DOI: 10.6084/m9.figshare.22829153
title: Magnetic control of self-assembly and disassembly in organic materials

description: Magnetic control of disassembly (TEM data)
DOI: 10.6084/m9.figshare.23259375
title: PHYSICAL EDUCATION TEACHERS IN TIMES OF PANDEMIC

description: ABSTRACT This paper reports on a study that investigated the experiences of 25 physical education (PE) teachers from public and private schools in Angeles City, Philippines, during the COVID-19 pandemic. The study found that many PE teachers encountered various challenges and were hesitant and unconfident about teaching PE during the pandemic. Additionally, many PE teachers were given non-teaching assignments and responsibilities, which added to their workload. The study highlights the importance of equipping teachers with the necessary skills and knowledge to adapt to the new teaching and learning modalities during the pandemic and providing support for PE teachers during this challenging time. The paper concludes by suggesting that future research could investigate the specific strategies and approaches that have been most effective in helping PE teachers overcome the challenges they face in teaching during the pandemic and the long-term effects of the pandemic on the teaching and learning of physical education.
DOI: 10.6084/m9.figshare.23259375.v1
title: PHYSICAL EDUCATION TEACHERS IN TIMES OF PANDEMIC

description: ABSTRACT This paper reports on a study that investigated the experiences of 25 physical education (PE) teachers from public and private schools in Angeles City, Philippines, during the COVID-19 pandemic. The study found that many PE teachers encountered various challenges and were hesitant and unconfident about teaching PE during the pandemic. Additionally, many PE teachers were given non-teaching assignments and responsibilities, which added to their workload. The study highlights the importance of equipping teachers with the necessary skills and knowledge to adapt to the new teaching and learning modalities during the pandemic and providing support for PE teachers during this challenging time. The paper concludes by suggesting that future research could investigate the specific strategies and approaches that have been most effective in helping PE teachers overcome the challenges they face in teaching during the pandemic and the long-term effects of the pandemic on the teaching and learning of physical education.
DOI: 10.6084/m9.figshare.23259383
title: The option for shared sovereignties in Latin America: the role of the Brazilian economy

description: ABSTRACT The recent integration affords are being hampered by the inconsistency of macroeconomic policies. In this paper an exercise of shared sovereignty is discussed. A special emphasis is given to exchange rate. The idea is to achieve macroeconomic stability.
DOI: 10.6084/m9.figshare.23259383.v1
title: The option for shared sovereignties in Latin America: the role of the Brazilian economy

description: ABSTRACT The recent integration affords are being hampered by the inconsistency of macroeconomic policies. In this paper an exercise of shared sovereignty is discussed. A special emphasis is given to exchange rate. The idea is to achieve macroeconomic stability.
DOI: 10.6084/m9.figshare.23259389
title: Reproductive biology of Piper species (Piperaceae): a review to link the past to the future

description: Abstract Piper species are important components of the understory in tropical and subtropical forests, and some species are of economic and medicinal importance. This genus has been studied in different areas of science. However, some questions remain unanswered after the new circumscription as proposed by phylogenetic studies. Here, I review different aspects related to the reproductive biology of Piper species (phenology, sexual expression, floral biology, pollination and mating systems), comparing the results between Neotropical (representing most of the studies carried out so far) and Paleotropical regions. Seventy-five species were analyzed. Some patterns can be observed, mainly in Neotropical species, such as the predominance of annual flowering and fruiting, dichogamy (generally incomplete protogyny) with gradual and sequential exposure of stigmas, asynchronous pollen release, and pollination by insects. Some aspects have been poorly studied, such as variations in sexual expression, the efficiency of different pollinators, and the chemical composition of floral volatiles associated with their role in pollination. In addition, I discuss remaining gaps and further studies that are required, mainly on Paleotropical Piper species, to obtain basic information on the reproductive biology of these plants. From this, comparisons with Neotropical species can be made, allowing the verification of patterns in this genus.
DOI: 10.6084/m9.figshare.23259389.v1
title: Reproductive biology of Piper species (Piperaceae): a review to link the past to the future

description: Abstract Piper species are important components of the understory in tropical and subtropical forests, and some species are of economic and medicinal importance. This genus has been studied in different areas of science. However, some questions remain unanswered after the new circumscription as proposed by phylogenetic studies. Here, I review different aspects related to the reproductive biology of Piper species (phenology, sexual expression, floral biology, pollination and mating systems), comparing the results between Neotropical (representing most of the studies carried out so far) and Paleotropical regions. Seventy-five species were analyzed. Some patterns can be observed, mainly in Neotropical species, such as the predominance of annual flowering and fruiting, dichogamy (generally incomplete protogyny) with gradual and sequential exposure of stigmas, asynchronous pollen release, and pollination by insects. Some aspects have been poorly studied, such as variations in sexual expression, the efficiency of different pollinators, and the chemical composition of floral volatiles associated with their role in pollination. In addition, I discuss remaining gaps and further studies that are required, mainly on Paleotropical Piper species, to obtain basic information on the reproductive biology of these plants. From this, comparisons with Neotropical species can be made, allowing the verification of patterns in this genus.