cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.20097536.v1
title: Early term ocular changes after cold compress application

description: ABSTRACT Purpose: To examine changes in the eyes after cold compress application at the early stage. Method: A total of 62 eyes from 62 healthy adult participants were included in this cross-sectional and comparative study. The subfoveal choroidal thickness and retinal nerve fiber thickness were measured by spectral-domain ocular coherence tomography. The central corneal thickness, anterior segment volume and depth, iridocorneal angle, and pupil diameter were measured by means of the Scheimpflug anterior segment imaging method. The measurements were repeated after 10 min of cold compress application, which was applied using special packs. The procedures were then repeated with non-cold packages to exclude the effect of pressure. Results: The average age of the participants was 30.74 ± 5.82 years. There was no significant change in the central corneal thickness after cold compress application, and there was a significant decrease in the anterior segment volume (p&lt;0.001), anterior segment depth (p&lt;0.001), and pupil diameter. Moreover, the iridocorneal angle increased (p=0.002). The subfoveal choroidal thickness decreased after the application of cold compress (p&lt;0.001). The overall disk thickness (p=0.034) and superior nasal scale (p=0.007) significantly decreased after the cold compress was administered during the evaluation of optic nerve fiber thickness. In contrast to that with the cold application, the subfoveal choroidal thickness and optic nerve fiber thickness did not change after the non-cold compress application (p&gt;0.05). Conclusion: Cold compress application may thus cause some physiological changes in the eyes, which necessitates the examination of its usage and effects.
DOI: 10.6084/m9.figshare.20097538
title: A didactic proposal based on metacognition and the analysis of meta-skills to think about the flaws in the learning of Protein Synthesis

description: Abstract A metacognitive didactic proposal was implemented with a group of first-year university students, randomly selected from four Biology courses, in order to (1) analyze the possible association between metacognitive practices (PM) of one hour a week with three key questions, and the overcoming of flaws in the learning of protein synthesis; (2) identify and compare cognitive meta-skills implicit in the reflections by the students who did or did not carry out PM, upon review of their answers to the exam questions on protein synthesis; and (3) describe the students’ answers that did or did not carry out PM, when dealing with a metacognitive activity autonomously during exam revision. The results support that the performance of PM during the course would allow students to improve their learning of complex topics, such as protein synthesis, and to value comprehension strategies over memorization or attention.
DOI: 10.6084/m9.figshare.20097538.v1
title: A didactic proposal based on metacognition and the analysis of meta-skills to think about the flaws in the learning of Protein Synthesis

description: Abstract A metacognitive didactic proposal was implemented with a group of first-year university students, randomly selected from four Biology courses, in order to (1) analyze the possible association between metacognitive practices (PM) of one hour a week with three key questions, and the overcoming of flaws in the learning of protein synthesis; (2) identify and compare cognitive meta-skills implicit in the reflections by the students who did or did not carry out PM, upon review of their answers to the exam questions on protein synthesis; and (3) describe the students’ answers that did or did not carry out PM, when dealing with a metacognitive activity autonomously during exam revision. The results support that the performance of PM during the course would allow students to improve their learning of complex topics, such as protein synthesis, and to value comprehension strategies over memorization or attention.
DOI: 10.6084/m9.figshare.20097541
title: Benign prostatic hyperplasia surgical treatment trends in the Public Health System in São Paulo, Brazil

description: ABSTRACT Objective To describe and compare the number of surgeries, mortality rate, length of hospital stay, and costs of transurethral resection of the prostate and open prostatectomy for the treatment of benign prostatic hyperplasia, between 2008 and 2018, in the Public Health System in São Paulo, Brazil. Methods Ecological and retrospective study using data from the informatics department of the Brazilian Public Health System database. Procedure codes were “open prostatectomy” and “transurethral resection of the prostate.” The outcomes analyzed were compared between transurethral resection of the prostate and open prostatectomy according to the hospital surgical volume and presence or absence of a residency program. Results A total of 18,874 surgeries were analyzed (77% transurethral resection of the prostate) and overall mortality was not statistically different between procedures. Intermediate and high-volume centers had shorter length of hospital stay than low-volume centers for transurethral resection of the prostate (3.28, 3.02, and 6.58 days, respectively, p=0.01 and p=0.004). Length of hospital stay was also shorter for open prostatectomy in high-volume compared to low-volume centers (4.86 versus 10.76 days, p=0.036). Intrahospital mortality was inversely associated with surgical volume for transurethral resection of the prostate. Centers with residency program had shorter length of hospital stay considering open prostatectomy and less mortality regarding transurethral resection of the prostate. Open prostatectomy was 64% more expensive than transurethral resection of the prostate. Conclusion The findings suggest the importance of investing in specialized centers, which could be potential referral centers for surgical cases.
DOI: 10.6084/m9.figshare.20097541.v1
title: Benign prostatic hyperplasia surgical treatment trends in the Public Health System in São Paulo, Brazil

description: ABSTRACT Objective To describe and compare the number of surgeries, mortality rate, length of hospital stay, and costs of transurethral resection of the prostate and open prostatectomy for the treatment of benign prostatic hyperplasia, between 2008 and 2018, in the Public Health System in São Paulo, Brazil. Methods Ecological and retrospective study using data from the informatics department of the Brazilian Public Health System database. Procedure codes were “open prostatectomy” and “transurethral resection of the prostate.” The outcomes analyzed were compared between transurethral resection of the prostate and open prostatectomy according to the hospital surgical volume and presence or absence of a residency program. Results A total of 18,874 surgeries were analyzed (77% transurethral resection of the prostate) and overall mortality was not statistically different between procedures. Intermediate and high-volume centers had shorter length of hospital stay than low-volume centers for transurethral resection of the prostate (3.28, 3.02, and 6.58 days, respectively, p=0.01 and p=0.004). Length of hospital stay was also shorter for open prostatectomy in high-volume compared to low-volume centers (4.86 versus 10.76 days, p=0.036). Intrahospital mortality was inversely associated with surgical volume for transurethral resection of the prostate. Centers with residency program had shorter length of hospital stay considering open prostatectomy and less mortality regarding transurethral resection of the prostate. Open prostatectomy was 64% more expensive than transurethral resection of the prostate. Conclusion The findings suggest the importance of investing in specialized centers, which could be potential referral centers for surgical cases.
DOI: 10.6084/m9.figshare.20097544
title: The pharmacist in the Brazilian Primary Health Care: a comparative analysis between 2014 and 2017

description: ABSTRACT The pharmacist play a vital role in PHC. However, studies addressing how pharmacists influence the health care network are still scarce. We aim to verify to what extent the inclusion of pharmacists in PHC Units (UBS) in the country is associated with the expanded structural aspects of pharmacies and drug availability in Brazil. This cross-sectional, retrospective, and analytical study employed secondary data from cycles 2 (2014) and 3 (2017) of the external evaluation of the Improvement of Access and Quality of Primary Care Program (PMAQ-AB) and the National Register of Health Facilities (CNES) databases. The results showed an essential centralization in drug dispensing over PMAQ-AB cycles 2 and 3. In contrast, we identified an improvement in the structural aspects of the UBS pharmaceutical services and an increase in the mean drug availability and the total UBS with drug availability ≥ 80%. Such advances were even more significant in the presence of registered pharmacists at the UBS. We conclude by stating that the presence of pharmacists in the PHC of the Unified Health System (SUS) enhances drug availability and provides better structural conditions for PHC pharmacy services.
DOI: 10.6084/m9.figshare.20097544.v1
title: The pharmacist in the Brazilian Primary Health Care: a comparative analysis between 2014 and 2017

description: ABSTRACT The pharmacist play a vital role in PHC. However, studies addressing how pharmacists influence the health care network are still scarce. We aim to verify to what extent the inclusion of pharmacists in PHC Units (UBS) in the country is associated with the expanded structural aspects of pharmacies and drug availability in Brazil. This cross-sectional, retrospective, and analytical study employed secondary data from cycles 2 (2014) and 3 (2017) of the external evaluation of the Improvement of Access and Quality of Primary Care Program (PMAQ-AB) and the National Register of Health Facilities (CNES) databases. The results showed an essential centralization in drug dispensing over PMAQ-AB cycles 2 and 3. In contrast, we identified an improvement in the structural aspects of the UBS pharmaceutical services and an increase in the mean drug availability and the total UBS with drug availability ≥ 80%. Such advances were even more significant in the presence of registered pharmacists at the UBS. We conclude by stating that the presence of pharmacists in the PHC of the Unified Health System (SUS) enhances drug availability and provides better structural conditions for PHC pharmacy services.
DOI: 10.6084/m9.figshare.20097545.v1
title: Sustainable Synthetic Strategies for the Preparation of Low Molecular Weight Drugs by Biotech Routes

description: For billions of years, the phenomena of life and biocatalysis have been intertwined. If in the beginning biocatalysis was fundamental for the origin of life, currently it is very important for the cleaner production of pharmaceuticals and fine chemical intermediates. There is no doubt that drugs have brought great benefits to humanity, but currently, the expectations of modern society are focused on drugs with greater safety, less environmental impact, more sustainable practices, and less energy use. This review intends to show how the challenges for the production of some low molecular weight drugs produced by synthetic routes that involve at least one biotechnological step using microorganisms or enzymes were faced. These biotechnological drug production routes are more sustainable than conventional synthetic routes, as they produce a much smaller amount of waste, use moderate reaction conditions, have lower energy consumption, and have lower metal consumption, in addition to being more selective. Additionally, many natural products have structures too complex to be produced exclusively by chemical routes. The large-scale and economical production of these drugs is of great importance for fighting cancer as well as inflammatory, infectious, autoimmune, metabolic, hormonal, cardiovascular, and neurological diseases, among others.
DOI: 10.6084/m9.figshare.20097545
title: Sustainable Synthetic Strategies for the Preparation of Low Molecular Weight Drugs by Biotech Routes

description: For billions of years, the phenomena of life and biocatalysis have been intertwined. If in the beginning biocatalysis was fundamental for the origin of life, currently it is very important for the cleaner production of pharmaceuticals and fine chemical intermediates. There is no doubt that drugs have brought great benefits to humanity, but currently, the expectations of modern society are focused on drugs with greater safety, less environmental impact, more sustainable practices, and less energy use. This review intends to show how the challenges for the production of some low molecular weight drugs produced by synthetic routes that involve at least one biotechnological step using microorganisms or enzymes were faced. These biotechnological drug production routes are more sustainable than conventional synthetic routes, as they produce a much smaller amount of waste, use moderate reaction conditions, have lower energy consumption, and have lower metal consumption, in addition to being more selective. Additionally, many natural products have structures too complex to be produced exclusively by chemical routes. The large-scale and economical production of these drugs is of great importance for fighting cancer as well as inflammatory, infectious, autoimmune, metabolic, hormonal, cardiovascular, and neurological diseases, among others.
DOI: 10.6084/m9.figshare.20097547
title: Carapace width/length-weight relationships for portunid crabs (genus Callinectes Stimpson, 1860) in northern Brazilian mangrove estuaries

description: Abstract Carapace width-carapace length (CW/CLRs), carapace width-weight (CW/WRs), and carapace length-weight (CL/WR) relationships are presented for the portunid species Callinectes bocourti A. Milne Edwards, 1879, Callinectes danae Smith, 1869, and Callinectes ornatus Ordway, 1863 from the northern coast of Brazil. A total of 85 crabs were collected between May and October 2015 in intertidal zones of the Caeté, Pirabas and Salinas estuaries. All species had strong relationships between measurements with a coefficient of determination (r 2) ranging between 0.97 and 0.99. The variable most strongly related to CW was CL with 99 % of the variability provided by C. ornatus. These relationships are a useful tool for field ecologists to estimate length and/or mass of portunid species, and it is not necessary to euthanize the organism to collect body measurements. Additionally, this study describes the first reference of CW/CLRs and CL/WRs for these portunid species in the region. The Callinectes species in Amazon estuaries are still poorly studied, and there is a need for monitoring their stocks due to its importance for artisanal fishery. The present data are important for supplying biological information required for an adequate management of this fishery.
DOI: 10.6084/m9.figshare.20097547.v1
title: Carapace width/length-weight relationships for portunid crabs (genus Callinectes Stimpson, 1860) in northern Brazilian mangrove estuaries

description: Abstract Carapace width-carapace length (CW/CLRs), carapace width-weight (CW/WRs), and carapace length-weight (CL/WR) relationships are presented for the portunid species Callinectes bocourti A. Milne Edwards, 1879, Callinectes danae Smith, 1869, and Callinectes ornatus Ordway, 1863 from the northern coast of Brazil. A total of 85 crabs were collected between May and October 2015 in intertidal zones of the Caeté, Pirabas and Salinas estuaries. All species had strong relationships between measurements with a coefficient of determination (r 2) ranging between 0.97 and 0.99. The variable most strongly related to CW was CL with 99 % of the variability provided by C. ornatus. These relationships are a useful tool for field ecologists to estimate length and/or mass of portunid species, and it is not necessary to euthanize the organism to collect body measurements. Additionally, this study describes the first reference of CW/CLRs and CL/WRs for these portunid species in the region. The Callinectes species in Amazon estuaries are still poorly studied, and there is a need for monitoring their stocks due to its importance for artisanal fishery. The present data are important for supplying biological information required for an adequate management of this fishery.
DOI: 10.6084/m9.figshare.20097548.v1
title: Comparative analysis of biofilm formation by Candida albicans and Candida krusei in different types of contact lenses

description: ABSTRACT Objective: To evaluate the Candida krusei and Candida albicans biofilm formation abilities on 5 different types of contact lenses and compare their metabolic activities and biomass. Methods: After biofilm formation by both the test species, their metabolic activity was assessed by the 2,3-bis (2-methoxy-4-nitro-5-sulfophenyl)-2H-tetrazolium-5-carboxanilide reduction assay with menadione, while the biomass was determined by staining with 0.4% crystal violet dye for further statistical analysis. Results: Both the Candida species could form biofilms on different types of contact lenses, with greater metabolic activities and lower biomass formation in rigid gas permeable lenses. Conclusion: Biofilm formation with greater metabolic activity and greater biomass were expected on soft contact lenses considering their surface hydrophobicity. However, the results demonstrated a greater metabolic activity on rigid contact lenses. This result has a great significance with regards to the increasing risk of microbial keratitis, although further studies are warranted to better elucidate the formation of biofilms on different types of contact lens materials in the future.
DOI: 10.6084/m9.figshare.20097548
title: Comparative analysis of biofilm formation by Candida albicans and Candida krusei in different types of contact lenses

description: ABSTRACT Objective: To evaluate the Candida krusei and Candida albicans biofilm formation abilities on 5 different types of contact lenses and compare their metabolic activities and biomass. Methods: After biofilm formation by both the test species, their metabolic activity was assessed by the 2,3-bis (2-methoxy-4-nitro-5-sulfophenyl)-2H-tetrazolium-5-carboxanilide reduction assay with menadione, while the biomass was determined by staining with 0.4% crystal violet dye for further statistical analysis. Results: Both the Candida species could form biofilms on different types of contact lenses, with greater metabolic activities and lower biomass formation in rigid gas permeable lenses. Conclusion: Biofilm formation with greater metabolic activity and greater biomass were expected on soft contact lenses considering their surface hydrophobicity. However, the results demonstrated a greater metabolic activity on rigid contact lenses. This result has a great significance with regards to the increasing risk of microbial keratitis, although further studies are warranted to better elucidate the formation of biofilms on different types of contact lens materials in the future.
DOI: 10.6084/m9.figshare.20097550
title: A Green Analytical Method Using Polyurethane Foam for The Extraction and Determination of Lauryl Ether Sulfate in Personal Care Hygiene Products

description: A green methodology was developed for the extraction and determination of lauryl ether sulfate in raw materials and commercial liquid soap and shower gel samples. The method avoids the use of organic solvents, offering a simple, cheap, and safe analysis. The methodology is based on the sorption of an ionic pair consisting of a cationic dye and an anionic surfactant onto polyurethane foam. The experimental variables were optimized by chemometry to obtain the conditions that maximized extraction of the ionic pair. Digital imaging and spectrophotometry were used for quantification in the linear concentration range from 10.0 to 100 mg L-1. The limits of detection and quantification were, respectively, 2.71 and 9.28 mg L-1 for digital imaging, and 1.74 and 5.83 mg L-1 for spectrophotometry. The methods showed good results when applied to commercial samples, with recoveries in the range 96.8-103%.
DOI: 10.6084/m9.figshare.20097550.v1
title: A Green Analytical Method Using Polyurethane Foam for The Extraction and Determination of Lauryl Ether Sulfate in Personal Care Hygiene Products

description: A green methodology was developed for the extraction and determination of lauryl ether sulfate in raw materials and commercial liquid soap and shower gel samples. The method avoids the use of organic solvents, offering a simple, cheap, and safe analysis. The methodology is based on the sorption of an ionic pair consisting of a cationic dye and an anionic surfactant onto polyurethane foam. The experimental variables were optimized by chemometry to obtain the conditions that maximized extraction of the ionic pair. Digital imaging and spectrophotometry were used for quantification in the linear concentration range from 10.0 to 100 mg L-1. The limits of detection and quantification were, respectively, 2.71 and 9.28 mg L-1 for digital imaging, and 1.74 and 5.83 mg L-1 for spectrophotometry. The methods showed good results when applied to commercial samples, with recoveries in the range 96.8-103%.
DOI: 10.6084/m9.figshare.19996654
title: A new species of Knodus (Characiformes: Characidae), with deep genetic divergence, from the Mearim and Munim river basins, Northeastern Brazil, and evidence for hidden diversity in adjacent river basins

description: Abstract A new species of Knodus from the Mearim and Munim River basins, Northeastern Brazil, is herein described based on integrative taxonomy, by using different molecular based species delimitation methods and independent approaches. The new species possesses the combination of character states that usually diagnoses the genus. The new species possesses a similar colour pattern to K. victoriae, which is also morphologically similar to it. The species described herein differs from K. victoriae by possessing more total vertebrae, more branched anal-fin rays, and fewer circumpeduncular scales. We also provide a detailed discussion of the morphological diagnostic features exhibited by Knodus species from adjacent river basins.
DOI: 10.6084/m9.figshare.19996654.v1
title: A new species of Knodus (Characiformes: Characidae), with deep genetic divergence, from the Mearim and Munim river basins, Northeastern Brazil, and evidence for hidden diversity in adjacent river basins

description: Abstract A new species of Knodus from the Mearim and Munim River basins, Northeastern Brazil, is herein described based on integrative taxonomy, by using different molecular based species delimitation methods and independent approaches. The new species possesses the combination of character states that usually diagnoses the genus. The new species possesses a similar colour pattern to K. victoriae, which is also morphologically similar to it. The species described herein differs from K. victoriae by possessing more total vertebrae, more branched anal-fin rays, and fewer circumpeduncular scales. We also provide a detailed discussion of the morphological diagnostic features exhibited by Knodus species from adjacent river basins.