cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.30952985
title: <b>How the </b><b>g</b><b>rey </b><b>b</b><b>ushchat </b><b>c</b><b>ombats </b><b>p</b><b>arasitic </b><b>e</b><b>ggs at </b><b>d</b><b>ifferent </b><b>l</b><b>aying </b><b>s</b><b>tages</b>

description: This study was conducted from March to August between 2021 and 2023 in the Liuzhi area (26°13′ N, 106°42′ E), Guizhou, southwest China. The grey bushchat prefers to nest in cultivated fields, barren slopes, and under the roots of grasses or rocky cover in scrub forests, choosing relatively concealed nest locations. Parasitic cuckoo eggs are highly similar to host eggs in background color but are larger in size than host eggs. Although this population experiences a relatively low parasitism rate (8.2%, N = 1,116), it is the primary host utilized by the common cuckoo in this study area (Zhong et al., 2023).We systematically searched the area for breeding nests early in the breeding season and recorded their reproductive status, including stages such as nest building, egg laying, egg incubation, and brood rearing. Particular attention was given to the timing of the first egg laying, as this study aimed to determine whether the egg-laying event (whether the host has commenced egg-laying) influences egg recognition. For each nest, we recorded or measured basic reproductive parameters, including the date of the first egg, the number of eggs in the clutch, and the period of incubation. A GPS kit(web.gpstool.com) was used for site marking, and a camera (Canon EOS R50 + RF-S 18-45mm Kit) was used to photograph nests and eggs.Here, we explored the strategies of egg recognition and rejection of the grey bushchat (<i>Saxicola ferreus haringtoni</i>), a host of the common cuckoo (<i>Cuculus canorus</i>), across different stages of egg-laying. The results indicated that the grey bushchat employed an "onset of laying" mechanism to recognize foreign eggs during the pre-laying stage, with significantly higher rejection rates in this period than post-laying. Additionally, the grey bushchat could remember the phenotype of its own eggs through a short learning process during the first egg-laying episode, without requiring physical presence of their own eggs in the nest. Furthermore, the host’s rejection behavior was shaped by the degree of egg mimicry and trade-offs associated with nest desertion costs. Our study reveals that the grey bushchat flexibly adopts distinct egg recognition and rejection strategies in response to varying parasitic contexts. Future research should incorporate<b> </b>individual variation in host reproductive background to better understand the evolution of egg-recognition mechanisms.
DOI: 10.6084/m9.figshare.30952985.v2
title: <b>How the </b><b>g</b><b>rey </b><b>b</b><b>ushchat </b><b>c</b><b>ombats </b><b>p</b><b>arasitic </b><b>e</b><b>ggs at </b><b>d</b><b>ifferent </b><b>l</b><b>aying </b><b>s</b><b>tages</b>

description: This study was conducted from March to August between 2021 and 2023 in the Liuzhi area (26°13′ N, 106°42′ E), Guizhou, southwest China. The grey bushchat prefers to nest in cultivated fields, barren slopes, and under the roots of grasses or rocky cover in scrub forests, choosing relatively concealed nest locations. Parasitic cuckoo eggs are highly similar to host eggs in background color but are larger in size than host eggs. Although this population experiences a relatively low parasitism rate (8.2%, N = 1,116), it is the primary host utilized by the common cuckoo in this study area (Zhong et al., 2023).We systematically searched the area for breeding nests early in the breeding season and recorded their reproductive status, including stages such as nest building, egg laying, egg incubation, and brood rearing. Particular attention was given to the timing of the first egg laying, as this study aimed to determine whether the egg-laying event (whether the host has commenced egg-laying) influences egg recognition. For each nest, we recorded or measured basic reproductive parameters, including the date of the first egg, the number of eggs in the clutch, and the period of incubation. A GPS kit(web.gpstool.com) was used for site marking, and a camera (Canon EOS R50 + RF-S 18-45mm Kit) was used to photograph nests and eggs.Here, we explored the strategies of egg recognition and rejection of the grey bushchat (<i>Saxicola ferreus haringtoni</i>), a host of the common cuckoo (<i>Cuculus canorus</i>), across different stages of egg-laying. The results indicated that the grey bushchat employed an "onset of laying" mechanism to recognize foreign eggs during the pre-laying stage, with significantly higher rejection rates in this period than post-laying. Additionally, the grey bushchat could remember the phenotype of its own eggs through a short learning process during the first egg-laying episode, without requiring physical presence of their own eggs in the nest. Furthermore, the host’s rejection behavior was shaped by the degree of egg mimicry and trade-offs associated with nest desertion costs. Our study reveals that the grey bushchat flexibly adopts distinct egg recognition and rejection strategies in response to varying parasitic contexts. Future research should incorporate<b> </b>individual variation in host reproductive background to better understand the evolution of egg-recognition mechanisms.
DOI: 10.6084/m9.figshare.30952985.v1
title: <b>How the </b><b>g</b><b>rey </b><b>b</b><b>ushchat </b><b>c</b><b>ombats </b><b>p</b><b>arasitic </b><b>e</b><b>ggs at </b><b>d</b><b>ifferent </b><b>l</b><b>aying </b><b>s</b><b>tages</b>

description: This study was conducted from March to August between 2021 and 2023 in the Liuzhi area (26°13′ N, 106°42′ E), Guizhou, southwest China. The grey bushchat prefers to nest in cultivated fields, barren slopes, and under the roots of grasses or rocky cover in scrub forests, choosing relatively concealed nest locations. Parasitic cuckoo eggs are highly similar to host eggs in background color but are larger in size than host eggs. Although this population experiences a relatively low parasitism rate (8.2%, N = 1,116), it is the primary host utilized by the common cuckoo in this study area (Zhong et al., 2023).We systematically searched the area for breeding nests early in the breeding season and recorded their reproductive status, including stages such as nest building, egg laying, egg incubation, and brood rearing. Particular attention was given to the timing of the first egg laying, as this study aimed to determine whether the egg-laying event (whether the host has commenced egg-laying) influences egg recognition. For each nest, we recorded or measured basic reproductive parameters, including the date of the first egg, the number of eggs in the clutch, and the period of incubation. A GPS kit(web.gpstool.com) was used for site marking, and a camera (Canon EOS R50 + RF-S 18-45mm Kit) was used to photograph nests and eggs.Here, we explored the strategies of egg recognition and rejection of the grey bushchat (<i>Saxicola ferreus haringtoni</i>), a host of the common cuckoo (<i>Cuculus canorus</i>), across different stages of egg-laying. The results indicated that the grey bushchat employed an "onset of laying" mechanism to recognize foreign eggs during the pre-laying stage, with significantly higher rejection rates in this period than post-laying. Additionally, the grey bushchat could remember the phenotype of its own eggs through a short learning process during the first egg-laying episode, without requiring physical presence of their own eggs in the nest. Furthermore, the host’s rejection behavior was shaped by the degree of egg mimicry and trade-offs associated with nest desertion costs. Our study reveals that the grey bushchat flexibly adopts distinct egg recognition and rejection strategies in response to varying parasitic contexts. Future research should incorporate<b> </b>individual variation in host reproductive background to better understand the evolution of egg-recognition mechanisms.
DOI: 10.25917/3fy5-aj30
title: Probucol in Alzheimer's Study 2020 (PIA 2020)
title: PIA

description: HeSANDA 1.0.0
description: The aim of this study is to understand whether or not treatment with Probucol supports cognitive function in participants with MCI/mild-dementia due to AD. The trial is specifically designed to provide evidence that treatment with Probucol may slow the decline of cognitive ability and functional state. The presence of cognitive impairment will be assessed using neuro-cognitive assessments. Participants will be randomly assigned to one of two groups, group 1 (placebo) or group 2 (treatment). This is a double-blind trial meaning the participant and study doctor will not be aware which group the participant has been randomised to. The study will be 104 weeks in duration (2 years). Participants will be required to take one tablet a day (with food) for the first three weeks, and then two tablets a day (morning and night, with food) for the remainder of the trial.
During the screening/pre-baseline phase participants will be asked about their medical history, complete a physical and neurological examination, an Electrocardiogram (ECG), and a blood test. Participants will also complete Neuro-cognitive assessments (memory and thinking tasks), as well as a Magnetic Resonance Imaging (MRI) scan and/or a Positron emission tomography (PET) scan.
During the treatment phase, participants will be required to visit the study doctor on 10 separate occasions (once a week for the first 3 weeks, and then at approximately 3 monthly intervals). Each visit will involve a health and safety assessment. Neuro-cognitive assessments will also be conducted at week 26 (6 months), 52 (12 months), and 78 (18 months). A blood sample will also be taken at each visit.
At completion of the treatment phase (week 104), participants will recomplete the Neuro-cognitive assessments, MRI and/or PET scan, and provide a final blood sample.
During the course of the trial, participants will be required to nominate a 'study partner' (spouse/partner/carer). The study partner will need to attend at least one screening visit. In addition, study partners should make themselves available by phone or preferably in person, to provide information to the study as required. Participants will need to identify a study partner to be eligible to take part in this study.
DOI: 10.15468/dl.nbc4cc
title: Occurrence Download

description: A dataset containing 1303 species occurrences available in GBIF matching the query:
{
 "and" : [
 "HasGeospatialIssue is false",
 "HasCoordinate is true",
 "OccurrenceStatus is Present",
 {
 "not" : {
 "BasisOfRecord" : [
 "is one of (Fossil, Living Specimen)"
 ]
 }
 },
 "Year is greater than or equal to 1900",
 "TaxonKey is Cymbopogon caesius"
 ]
}

 The dataset includes 1303 records from 55 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0010691-260208012135463/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.5281/zenodo.18616982
title: Infrared_Defect_Detection
DOI: 10.5281/zenodo.18616983
title: Infrared_Defect_Detection
DOI: 10.15468/dl.jz8s94
title: Occurrence Download

description: A dataset containing 706 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Croton macrostachyus",
 "HasCoordinate is true",
 "OccurrenceStatus is Present",
 {
 "not" : {
 "BasisOfRecord" : [
 "is Fossil"
 ]
 }
 }
 ]
}

 The dataset includes 706 records from 40 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0010694-260208012135463/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.8ktun2
title: Occurrence Download

description: A dataset containing 33 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Vanda tricolor",
 "HasCoordinate is true",
 "BasisOfRecord is one of (Specimen)"
 ]
}

 The dataset includes 33 records from 10 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0010695-260208012135463/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.25917/5cg2-cb43
title: A randomised trial of the pro-phylactic use of melatonin in critically ill patients to evaluate if this leads to a reduction in incidence of delirium (Pro-MEDIC study)
title: Pro-MEDIC

description: HeSANDA 1.0.0
description: Rationale:
Delirium is defined as acute organic brain dysfunction characterised by inattention and disturbance of cognition. It is common in the intensive care unit and is associated with poorer outcomes. Good quality sleep is important in the prevention and management of delirium. Melatonin is a natural hormone secreted by the pineal gland which helps in the regulation of the sleep-wake cycle. It is possible that melatonin supplementation in intensive care improves sleep and prevents delirium. 
Methods and design:
The 'Prophylactic Melatonin for Delirium in Intensive Care' study is a multi-centre, randomised, double-blinded, placebo-controlled trial. The primary objective of this study is to determine whether melatonin given prophylactically decreases delirium in critically ill patients. A total of 850 ICU patients have been randomised (1:1) to receive either melatonin or a placebo. Participants were monitored twice daily for symptoms of delirium.
Results:
This paper and the attached additional files describe the statistical analysis plan (SAP) for the trial. The SAP has been developed and submitted for publication before the database has been locked and before the treatment allocation has been unblinded. The SAP contains details of analyses to be undertaken, which will be reported in the primary and secondary publications.
DOI: 10.6084/m9.figshare.29627516
title: ALP

description: Protein-water interactions fundamentally shape the structure, stability, dynamics, and functionality of proteins. However, the heterogeneous nature of the protein-water interface and the disparity in their dynamic interplay make it challenging to understand how local water perturbations influence protein structural dynamics over space and time. In this study, we introduce a photochromic molecule, spiropyran, to modify a specific residue of proteins, thereby achieving a reversible, residue-specific, and amplified perturbation on the hydrophobicity of protein surfaces. With the aid of controlled, amplified hydrophobic perturbations, we reveal that even residue-level changes in hydrophobicity induce significant global alterations in protein hydration patterns. These hydration shifts propagate in an amino acid sequence-dependent manner, initiating dramatic influences overall protein architecture and catalytic performance. Our findings establish that interfacial water networks not only capture the surface physicochemical patterns of proteins but also mediate the propagation of local perturbations into broader structural and functional fluctuations. By shifting the paradigm from “structure-function” to “structure-hydration-function”, our work provides innovative perspectives into understanding protein architecture and guiding future drug design strategies.
DOI: 10.6084/m9.figshare.29627516.v1
title: ALP

description: Protein-water interactions fundamentally shape the structure, stability, dynamics, and functionality of proteins. However, the heterogeneous nature of the protein-water interface and the disparity in their dynamic interplay make it challenging to understand how local water perturbations influence protein structural dynamics over space and time. In this study, we introduce a photochromic molecule, spiropyran, to modify a specific residue of proteins, thereby achieving a reversible, residue-specific, and amplified perturbation on the hydrophobicity of protein surfaces. With the aid of controlled, amplified hydrophobic perturbations, we reveal that even residue-level changes in hydrophobicity induce significant global alterations in protein hydration patterns. These hydration shifts propagate in an amino acid sequence-dependent manner, initiating dramatic influences overall protein architecture and catalytic performance. Our findings establish that interfacial water networks not only capture the surface physicochemical patterns of proteins but also mediate the propagation of local perturbations into broader structural and functional fluctuations. By shifting the paradigm from “structure-function” to “structure-hydration-function”, our work provides innovative perspectives into understanding protein architecture and guiding future drug design strategies.
DOI: 10.60854/gdn2-fp40
title: ROCIT
title: Restoration Of gut microflora in Critical Illness Trial (ROCIT)

description: HeSANDA 1.0.0
description: The Restoration Of gut microflora in Critical Illness Trial (ROCIT) study is a multicentre, randomised, placebo-controlled, parallel-group, two-sided superiority trial that will enrol 220 patients in five CUs. Adult patients who are within 48 hours of admission to an ICU and are expected to require intensive care beyond the next calendar day will be randomised in a 1:1 ratio to receive early and sustained Lactobacillus plantarum 299v probiotic therapy in addition to usual care or placebo in addition to usual care. The primary endpoint is days alive and out of hospital to day 60.
DOI: 10.34740/kaggle/dsv/14814352
title: Paddy leaf disease detection project report.
DOI: 10.15468/dl.fh895u
title: Occurrence Download

description: A dataset containing 1444 species occurrences available in GBIF matching the query:
{
 "and" : [
 "HasGeospatialIssue is false",
 "HasCoordinate is true",
 "OccurrenceStatus is Present",
 {
 "not" : {
 "BasisOfRecord" : [
 "is one of (Fossil, Living Specimen)"
 ]
 }
 },
 "Year is greater than or equal to 1900",
 "TaxonKey is Cymbopogon citratus"
 ]
}

 The dataset includes 1444 records from 220 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0010699-260208012135463/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.60854/zmg4-k838
title: AUS-mTBI
title: Effect of implementing novel health informatics approaches on concussion symptoms through an app-guided recovery program for people with mild TBI

description: HeSANDA 1.0.0
description: Based on similar research in other countries, feasible outcomes can be generated from population sizes as low as 37 individuals, through to large longitudinal cohorts of more than 10,000.
This project aims to recruit 5000 participants across Australia during each the first and second year of recruitment. With wide recruitment we aim to have a population-based capture of adults and children who have experienced a mTBI. Custom machine learning models and related algorithms (such as RandomForests, XGBoost, etc.) will be built to analyse this high-quality dataset to predict outcomes and identify better care pathways for people following mTBI. Model robustness and uncertainty will be tested using extensive sensitivity analyses (including probabilistic sensitivity analyses) and calibration to observed trends in outcome.
Baseline characteristics will be compared between men and women using Chi-square tests for categorical variables and t-tests for continuous variables. The analyses will be repeated by age, mechanism of injury, outcome (PPCS or no PPCS), nature of injury (single event or sequelae), and symptoms at presentation. All eligible participants will be included in the analyses.
Analysis of data not involving machine learning models will be performed using R, SPSS or Stata V17 statistical software (StataCorp LP, College Station, Tex).
DOI: 10.15468/dl.d7dj6w
title: Occurrence Download

description: A dataset containing 2431 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Ekebergia capensis",
 "HasCoordinate is true",
 "OccurrenceStatus is Present",
 {
 "not" : {
 "BasisOfRecord" : [
 "is Fossil"
 ]
 }
 }
 ]
}

 The dataset includes 2431 records from 96 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0010698-260208012135463/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.fsdphw
title: Occurrence Download

description: A dataset containing 457 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Vanilla planifolia",
 "HasCoordinate is true",
 "BasisOfRecord is one of (Specimen)"
 ]
}

 The dataset includes 457 records from 94 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0010700-260208012135463/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.60854/4rqm-n332
title: The MyTIME clinical trial
title: Melatonin supplementation To reduce the Induction of labour rate in first-time MothErs

description: HeSANDA 1.0.0
description: Allocation to intervention: Randomised controlled trial
Procedure for enrolling a subject and allocating the treatment (allocation concealment procedures): Allocation will occur by central randomisation by phone or computer
Methods used to generate the sequence in which subjects will be randomised (sequence generation) : Simple randomisation using a randomisation table created by computer software (i.e. computerised sequence generation)
Masking / blinding: Blinded (masking used)
Who is / are masked / blinded?: The people receiving the treatment/s
Phase: Phase 3
Type of endpoint/s Efficacy
Statistical methods / analysis Sample Size: Primary Outcome - Induction of Labour: Within the study site, the induction of labour rate for nulliparous women is 43%. Should antenatal melatonin be effective, we propose that a clinically relevant impact would see an overall decrease in the rate of inductions by 30%, from 43% down to 30%. Total sample size of 530 women (~265 per group) will attain 80% power to detect this clinically relevant reduction of induction rate in the melatonin group (odds ratio of 0.57) while using logistic regression analysis with adjustment for the stratification factors and other relevant covariates with an r-squared of 0.025 at alpha=0.025. This sample size is also inflated for account for a 10% loss to follow-up (Power and Sample Size Program for Windows, version 2019) and to allow for a single interim analysis. Power &gt;80% will also be achieved for all continuous secondary outcomes and for most categorical secondary outcomes, except for the low incidence secondary outcomes ie APGAR at 5 mins.
Statistical Analysis Data will be analysed on intention-to-treat basis. Logistic and binomial regression analyses will be performed on primary endpoint and other binary outcomes. Linear and/or Cox proportional hazards regression will be used to examine group differences between the continuous and time to event outcomes. Melatonin adherence will be assessed and, if applicable, supplementary analyses on the adherent subgroup and per treatment received will also be performed. All hypothesis tests will be two-sided with alpha=0.05. Data analyses will be performed using STATA statistical software (version 16).
DOI: 10.60854/dsyq-qg20
title: ATTAC (Antigen-targeted therapy against cancer)
title: A pilot study to evaluate the safety and efficacy of a personalised cancer vaccine in patients with completely resected early stage lung cancer

description: HeSANDA 1.0.0
description: Dataset includes: demographic data, diagnostic data, and safety data for a pilot study of 6 participants with early stage non small cell lung cancer (NSCLC) to evaluate the safety of a personalised tumour neo-antigen peptide vaccine strategy. The personalised neo-antigen peptide vaccine will comprise of 5 to 10 candidate tumour neo-antigens identified by genome sequencing.