DOI: 10.5061/dryad.m67g1
title: Data from: Performance of glomerular filtration rate estimation equations in Congolese healthy adults: inopportunity of ethnic correction

description: Context and objective: In the estimation of glomerular filtration rate
 (GFR), ethnicity is an important determinant. However, all existing
 equations have been built solely from Caucasian and Afro-American
 populations and they are potentially inaccurate for estimating GFR in
 African populations. We therefore evaluated the performance of different
 estimated GFR (eGFR) equations in predicting measured GFR (mGFR). Methods:
 In a cross-sectional study, 93 healthy adults were randomly selected in
 the general population of Kinshasa, Democratic Republic Congo, between
 June 2015 and April 2016. We compared mGFR by plasma clearance of iohexol
 with eGFR obtained with the Modified Diet in Renal Disease (MDRD) equation
 with and without ethnic factor, the Chronic Kidney Disease Epidemiology
 (CKD-EPI) serum creatinine (SCr)-based equation, with and without ethnic
 factor, the cystatin C-based CKD-EPI equation (CKD-EPI SCys) and with the
 combined equation (CKD-EPI SCrCys) with and without ethnic factor. The
 performance of the equations was studied by calculating bias, precision
 and accuracy within 30% (P30) of mGFR. Results: There were 48 women and 45
 men. Their mean age was 45.0±15.7 years and the average body surface area
 was 1.68±0.16m2. Mean mGFR was 92.0±17.2 mL/min/1.73m2 (range of 57 to 141
 mL/min/1.73m2). Mean eGFRs with the different equations were 105.5±30.1
 and 87.2±24.8 mL/min/1.73m² for MDRD with and without ethnic factor,
 respectively; 108.8±24.1 and 94.3±20.9 mL/min/1.73m² for CKD-EPI SCr with
 and without ethnic factor, respectively, 93.5±18.6 mL/min/1.73m² for
 CKD-EPI SCys; 93.5±18.0 and 101±19.6 mL/min/ 1.73m2 for CKD-EPI SCrCys
 with and without ethnic factor, respectively. All equations slightly
 overestimated mGFR except MDRD without ethnic factor which underestimated
 by -3.8±23.0 mL/min /1.73m2. Both CKD-EPI SCr and MDRD with ethnic factors
 highly overestimated mGFR with a bias of 17.9±19.2 and 14.5±27.1
 mL/min/1.73m2, respectively. There was a trend for better P30 for MDRD and
 CKD-EPI SCr without than with the ethnic factor [86.0% versus 79.6% for
 MDRD (p = 0.21) and 81.7% versus 73.1% for the CKD-EPI SCr equations (p =
 0.057)]. CKD-EPI SCrCys and CKD-EPI SCys were more effective than
 creatinine-based equations. Conclusion: In the Congolese healthy
 population, MDRD and CKD-EPI equations without ethnic factors had better
 performance than the same equations with ethnic factor. The equations
 using Cys C (alone or combined with SCr) performed better than the
 creatinine-based equations.
description: Dataset
 IOHEXOLmGFR: measured
 glomerular filtration rate, eGFR:estimated glomerular filtration rate,
 eGFR MDRD: estimated glomerular filtration rate by Modification of Diet in
 Renal Disease with ethnic factor, eGFRMDRDnef: estimated glomerular
 filtration rate by Modification of Diet in Renal Disease without ethnic
 factor, eGFR CKD-EPIScr:estimated glomerular filtration rate by Chronic
 Kidney Disease-Epidemiology Collaboration equation based on serum
 creatinine only with ethnic factor, eGFRCKD-EPI Scrnef: estimated
 glomerular filtration rate by Chronic Kidney Disease-Epidemiology
 Collaboration based on serum creatinine only without ethnic factor,
 eGFRSCrCys: estimated glomerular filtration rate by Chronic Kidney
 Disease-Epidemiology Collaboration combining creatinine and cystatine C
 with ethnic factor, eGFRSCrCysnef: estimated glomerular filtration rate by
 Chronic Kidney Disease-Epidemiology Collaboration combining creatinine and
 cystatine C without ethnic factor.