DOI: 10.5281/zenodo.13490759
title: Spiked Systems for Colonic Drug Delivery: Architectural Opportunities and Quality Assurance of Selective Laser Sintering - Underlying data

description: Underlying microfocus CT and XCT image-based modeling of Spiked Systems for Colonic Drug Delivery: Architectural Opportunities and Quality Assurance of Selective Laser Sintering by 

Angelos Gkaragkounis a,b,*, Konstantina Chachlioutaki a,c, Orestis L. Katsamenis d,e,, Fernando Alvarez-Borges d, Savvas Koltsakidis f, Ioannis Partheniadis a, Nikolaos Bouropoulos g,h Ioannis S. Vizirianakisi, Dimitrios Tzetzis f, Ioannis Nikolakakis a, Chris H. J. Verhoeven b, Dimitrios G. Fatouros a,c,*, Kjeld J. C. van Bommel b,*



a Laboratory of Pharmaceutical Technology, Department of Pharmacy, School of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki GR 54124, Greece

bThe Netherlands Organization for Applied Scientific Research (TNO), Eindhoven 5656 AE, The Netherlands

c1 μ-VIS X-Ray Imaging Centre, Faculty of Engineering and Physical Sciences, University of Southampton, Southampton, SO17 1BJ, UK 

c2 Institute for Life Sciences, University of Southampton, University Road, Highfield, Southampton SO17 1BJ, UK

e Department of Materials Science, University of Patras, Patras, 26504 Rio, Greece

f Laboratory of Pharmacology, Department of Pharmacy, Aristotle University of Thessaloniki, Thessaloniki, GR 54124, Greece

g Digital Manufacturing and Materials Characterization Laboratory, School of Science and Technology, International Hellenic University, Thessaloniki, 57001, Greece
description: Data Repository Index

This repository contains all XCT and Permeability analysis datasets, exported images, and multemedia associated with this paper. Below is a detailed description of each file:



1. Analysis and Raw Data Files





Analysis.opju (1.06 MB)Origin project file containing detailed data plots and analysis results of the histograms depicting the distribution of local thickness values




Analysis.xlsx (551.24 KB)Spreadsheet with numerical data summaries, including porosity percentages, pore size distributions, and local thickness values.




3739_spike2_1096x1092x89_1x8bit.raw (1.07 GB)Raw μCT data of the spiked object in 8-bit format.




spike1_AnalysisOpenPNM.ORSSession (1.93 GB)OpenPNM Dragonfly(R) session file for porosity network analysis.




spike2-AvizoProject.zip (473.91 KB)Avizo project file for 3D Permeability analysis and visualisation.





2. Processed Data and Visualisations





Material-Pore-PhaseThickness-5-6SpikesHistograms.zip (462.09 KB)Histogram data for thickness distributions across the material and pore phases.




PHAR11131-DOSF_5Spikes_Vol-03.png (613.55 KB)3D photorealistic representation of the 5-spike object.




PHAR11144-DOSF_6Spikes_poreThickness-2D-01.png (448.17 KB)2D slice showing local thickness mapping of the pore phase in the 6-spike object.




PHAR11144-DOSF_6Spikes_3D-01.png (523.23 KB)3D volume rendering of the 6-spike object.




Permeability_6Spikes_PHAR11144-DOSF.png (908.02 KB)Visual summary of permeability analysis results.




PHAR11131-DOSF_5spikes_thickness-3D-02.png (1.38 MB)3D volume rendering of local thickness distribution in the 5-spike object.


PHAR11144-DOSF_6Spikes_3D-VolThickness-02.png (1.11 MB)3D volume thickness map for the 6-spike object.




3. Animation Files



Permeability_6Spikes_PHAR11144-DOSF_animation2.mp4 (17.88 MB)Animation showing the permeability flow paths and local thickness analysis in the 6-spike object.




4. Image Processing Workflows





PHAR11144-DOSF_6Spikes_2D-SegmWorkflow.zip (993.10 KB)Segmentation workflow detailing the steps for thresholding, mask creation, and watershed-based separation.





Note:

All raw data and processed files are provided for transparency and reproducibility.