cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.26322796
title: Genotypic variation in the promoter region of the CRH-248 gene interacts with early rearing experiences to disrupt the development of the HPA axis in infant rhesus macaques (<i>Macaca mulatta</i>)

description: Aberrant functioning of the hypothalamic-pituitary-adrenal (HPA) axis is a hallmark of conditions such as depression, anxiety disorders, and post-traumatic stress disorder. Early-life adversity and genetic variation can interaction to disrupt HPA axis regulation, potentially contributing to certain forms of psychopathology. This study employs a rhesus macaque model to investigate how early parental neglect interacts with a single nucleotide polymorphism within the promoter region of the corticotropin-releasing hormone (CRH-248) gene, impacting the development of the HPA axis. For the initial six months of life, 307 rhesus monkey infants (<i>n</i> = 146 females, <i>n</i> = 161 males) were either reared with their mothers (MR) in conditions emulating the natural environment (control group) or raised without maternal care in groups with constant or 3-hours daily access to same-aged peers (NR). Blood samples collected on days 30, 60, 90, and 120 of life under stressful conditions were assayed for plasma cortisol and adrenocorticotropic hormone (ACTH) concentrations. Findings revealed that NR subjects exhibited a significant blunting of both ACTH and cortisol concentrations. Notably, there was a gene-by-environment interaction observed for ACTH and cortisol levels, with NR subjects with the polymorphism displaying higher ACTH concentrations and lower cortisol concentrations. To the extent that these results generalize to humans, they suggest that early parental neglect may render individuals vulnerable to HPA axis dysfunction, a susceptibility that is modulated by CRH-248 genotype—a gene-by-environment interaction that leaves a lasting developmental signature.
DOI: 10.6084/m9.figshare.26322796.v1
title: Genotypic variation in the promoter region of the CRH-248 gene interacts with early rearing experiences to disrupt the development of the HPA axis in infant rhesus macaques (<i>Macaca mulatta</i>)

description: Aberrant functioning of the hypothalamic-pituitary-adrenal (HPA) axis is a hallmark of conditions such as depression, anxiety disorders, and post-traumatic stress disorder. Early-life adversity and genetic variation can interaction to disrupt HPA axis regulation, potentially contributing to certain forms of psychopathology. This study employs a rhesus macaque model to investigate how early parental neglect interacts with a single nucleotide polymorphism within the promoter region of the corticotropin-releasing hormone (CRH-248) gene, impacting the development of the HPA axis. For the initial six months of life, 307 rhesus monkey infants (<i>n</i> = 146 females, <i>n</i> = 161 males) were either reared with their mothers (MR) in conditions emulating the natural environment (control group) or raised without maternal care in groups with constant or 3-hours daily access to same-aged peers (NR). Blood samples collected on days 30, 60, 90, and 120 of life under stressful conditions were assayed for plasma cortisol and adrenocorticotropic hormone (ACTH) concentrations. Findings revealed that NR subjects exhibited a significant blunting of both ACTH and cortisol concentrations. Notably, there was a gene-by-environment interaction observed for ACTH and cortisol levels, with NR subjects with the polymorphism displaying higher ACTH concentrations and lower cortisol concentrations. To the extent that these results generalize to humans, they suggest that early parental neglect may render individuals vulnerable to HPA axis dysfunction, a susceptibility that is modulated by CRH-248 genotype—a gene-by-environment interaction that leaves a lasting developmental signature.
DOI: 10.6084/m9.figshare.27939360
title: California Stress, Trauma, and Resilience Study (CalSTARS) protocol: A multiomics-based cross-sectional investigation and randomized controlled trial to elucidate the biology of ACEs and test a precision intervention for reducing stress and enhancing resilience

description: Adverse Childhood Experiences (ACEs) are very common and presently implicated in 9 out of 10 leading causes of death in the United States. Despite this fact, our mechanistic understanding of how ACEs impact health is limited. Moreover, interventions for reducing stress presently use a one-size-fits-all approach that involves no treatment tailoring or precision. To address these issues, we developed a combined cross-sectional study and randomized controlled trial, called the California Stress, Trauma, and Resilience Study (CalSTARS), to (a) characterize how ACEs influence multisystem biological functioning in adults with all levels of ACE burden and current perceived stress, using multiomics and other complementary approaches, and (b) test the efficacy of our new California <b>Prec</b>ision <b>I</b>ntervention for <b>S</b>tress and R<b>e</b>silience (PRECISE) in adults with elevated perceived stress levels who have experienced the full range of ACEs. The primary trial outcome is perceived stress, and the secondary outcomes span a variety of psychological, emotional, biological, and behavioral variables, as assessed using self-report measures, wearable technologies, and extensive biospecimens (i.e. DNA, saliva, blood, urine, & stool) that will be subjected to genomic, transcriptomic, proteomic, metabolomic, lipidomic, immunomic, and metagenomic/microbiome analysis. In this protocol paper, we describe the scientific gaps motivating this study as well as the sample, study design, procedures, measures, and planned analyses. Ultimately, our goal is to leverage the power of cutting-edge tools from psychology, multiomics, precision medicine, and translational bioinformatics to identify social, molecular, and immunological processes that can be targeted to reduce stress-related disease risk and enhance biopsychosocial resilience in individuals and communities worldwide.
DOI: 10.6084/m9.figshare.27939360.v1
title: California Stress, Trauma, and Resilience Study (CalSTARS) protocol: A multiomics-based cross-sectional investigation and randomized controlled trial to elucidate the biology of ACEs and test a precision intervention for reducing stress and enhancing resilience

description: Adverse Childhood Experiences (ACEs) are very common and presently implicated in 9 out of 10 leading causes of death in the United States. Despite this fact, our mechanistic understanding of how ACEs impact health is limited. Moreover, interventions for reducing stress presently use a one-size-fits-all approach that involves no treatment tailoring or precision. To address these issues, we developed a combined cross-sectional study and randomized controlled trial, called the California Stress, Trauma, and Resilience Study (CalSTARS), to (a) characterize how ACEs influence multisystem biological functioning in adults with all levels of ACE burden and current perceived stress, using multiomics and other complementary approaches, and (b) test the efficacy of our new California <b>Prec</b>ision <b>I</b>ntervention for <b>S</b>tress and R<b>e</b>silience (PRECISE) in adults with elevated perceived stress levels who have experienced the full range of ACEs. The primary trial outcome is perceived stress, and the secondary outcomes span a variety of psychological, emotional, biological, and behavioral variables, as assessed using self-report measures, wearable technologies, and extensive biospecimens (i.e. DNA, saliva, blood, urine, & stool) that will be subjected to genomic, transcriptomic, proteomic, metabolomic, lipidomic, immunomic, and metagenomic/microbiome analysis. In this protocol paper, we describe the scientific gaps motivating this study as well as the sample, study design, procedures, measures, and planned analyses. Ultimately, our goal is to leverage the power of cutting-edge tools from psychology, multiomics, precision medicine, and translational bioinformatics to identify social, molecular, and immunological processes that can be targeted to reduce stress-related disease risk and enhance biopsychosocial resilience in individuals and communities worldwide.
DOI: 10.6084/m9.figshare.25521106
title: Chronic adolescent stress alters GR-FKBP5 interactions in the hippocampus of adult female rats

description: Chronic stress exposure during development can have lasting behavioral consequences that differ in males and females. More specifically, increased depressive behaviors in females, but not males, are observed in both humans and rodent models of chronic stress. Despite these known stress-induced outcomes, the molecular consequences of chronic adolescent stress in the adult brain are less clear. The stress hormone corticosterone activates the glucocorticoid receptor, and activity of the receptor is regulated through interactions with co-chaperones—such as the immunophilin FK506 binding proteins 5 (FKBP5). Previously, it has been reported that the adult stress response is modified by a history of chronic stress; therefore, the current study assessed the impact of chronic adolescent stress on the interactions of the glucocorticoid receptor (GR) with its regulatory co-chaperone FKBP5 in response to acute stress in adulthood. Although protein presence for FKBP5 did not differ by group, assessment of GR-FKBP5 interactions demonstrated that adult females with a history of chronic adolescent stress had elevated GR-FKBP5 interactions in the hippocampus following an acute stress challenge which could potentially contribute to a reduced translocation pattern given previous literature describing the impact of FKBP5 on GR activity. Interestingly, the altered co-chaperone interactions of the GR in the stressed female hippocampus were not coupled to an observable difference in transcription of GR-regulated genes. Together, these studies show that chronic adolescent stress causes lasting changes to co-chaperone interactions with the glucocorticoid receptor following stress exposure in adulthood and highlight the potential role that FKBP5 plays in these modifications. Understanding the long-term implications of adolescent stress exposure will provide a mechanistic framework to guide the development of interventions for adult disorders related to early life stress exposures.
DOI: 10.6084/m9.figshare.25521106.v1
title: Chronic adolescent stress alters GR-FKBP5 interactions in the hippocampus of adult female rats

description: Chronic stress exposure during development can have lasting behavioral consequences that differ in males and females. More specifically, increased depressive behaviors in females, but not males, are observed in both humans and rodent models of chronic stress. Despite these known stress-induced outcomes, the molecular consequences of chronic adolescent stress in the adult brain are less clear. The stress hormone corticosterone activates the glucocorticoid receptor, and activity of the receptor is regulated through interactions with co-chaperones—such as the immunophilin FK506 binding proteins 5 (FKBP5). Previously, it has been reported that the adult stress response is modified by a history of chronic stress; therefore, the current study assessed the impact of chronic adolescent stress on the interactions of the glucocorticoid receptor (GR) with its regulatory co-chaperone FKBP5 in response to acute stress in adulthood. Although protein presence for FKBP5 did not differ by group, assessment of GR-FKBP5 interactions demonstrated that adult females with a history of chronic adolescent stress had elevated GR-FKBP5 interactions in the hippocampus following an acute stress challenge which could potentially contribute to a reduced translocation pattern given previous literature describing the impact of FKBP5 on GR activity. Interestingly, the altered co-chaperone interactions of the GR in the stressed female hippocampus were not coupled to an observable difference in transcription of GR-regulated genes. Together, these studies show that chronic adolescent stress causes lasting changes to co-chaperone interactions with the glucocorticoid receptor following stress exposure in adulthood and highlight the potential role that FKBP5 plays in these modifications. Understanding the long-term implications of adolescent stress exposure will provide a mechanistic framework to guide the development of interventions for adult disorders related to early life stress exposures.
DOI: 10.5281/zenodo.14437762
title: 20-year overview of fertility preservation in boys

description: the current international practices with regard to cryopreservation of immature testicular tissue
DOI: 10.5281/zenodo.14437763
title: 20-year overview of fertility preservation in boys

description: the current international practices with regard to cryopreservation of immature testicular tissue
DOI: 10.15468/dl.ejqerm
title: Occurrence Download

description: A dataset containing 441 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Cylichnidae",
 "Geometry POLYGON((170 20, 170 50, 120 50, 120 20, 170 20))",
 "HasCoordinate is true"
 ]
}

 The dataset includes 441 records from 22 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0033047-241126133413365/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.srs3gd
title: Occurrence Download

description: A dataset containing 69 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Scaphandridae",
 "Geometry POLYGON((170 20, 170 50, 120 50, 120 20, 170 20))",
 "HasCoordinate is true"
 ]
}

 The dataset includes 69 records from 14 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0033048-241126133413365/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.tjgndv
title: Occurrence Download

description: A dataset containing 11227 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Muricidae",
 "Geometry POLYGON((170 20, 170 50, 120 50, 120 20, 170 20))",
 "HasCoordinate is true"
 ]
}

 The dataset includes 11227 records from 91 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0033049-241126133413365/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.s9v64t
title: Occurrence Download

description: A dataset containing 15255 species occurrences available in GBIF matching the query:
{
 "DatasetKey" : [
 "is Anymals+plants - Citizen Science Data"
 ]
}

 The dataset includes 15255 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0033051-241126133413365/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.v4pkt7
title: Occurrence Download

description: A dataset containing 5686 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Buccinidae",
 "Geometry POLYGON((170 20, 170 50, 120 50, 120 20, 170 20))",
 "HasCoordinate is true"
 ]
}

 The dataset includes 5686 records from 82 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0033050-241126133413365/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.13016/wyua-muuk
title: Vertical Column Densities of LNOx*

description: Slant column densities (SCD) of NO2 are retrieved by the OMI satellite. Following the method described in Bucsela et al., (2019), these SCD are converted to Vertical Column Densities (VCD) of LNOx*. There are 6 values for these column amounts. Those used in Seiler et al., (2025) are that of VLNOxhi_cld. This was completed for three case studies: June 11th, 2012, August 5th, 2007, and August 6th, 2006.
description: This dataset was created by Eric Bucsela and contains vertical column densities of LNOx before background contribution was removed (LNOx*). There are 6 values for these column amounts, one for each method used to retrieve vertical column densities. The method used in Seiler et al., (2025) is that of VLNOxhi_cld. There are files for three case studies: June 11th, 2012, August 5th, 2007, August 6th, 2006.
DOI: 10.15468/dl.wnmx9r
title: Occurrence Download

description: A dataset containing 677 species occurrences available in GBIF matching the query:
{
 "and" : [
 "DatasetKey is one of (Australian National Insect Collection, Australian Museum provider for OZCAM, NSW DPI Biosecurity Collections, Queensland Museum provider for OZCAM, Museums Victoria provider for OZCAM, Queen Victoria Museum Art Gallery provider for OZCAM, Canadian Museum of Nature - National Biodiversity Cryobank of Canada, Canadian Museum of Nature Insect Collection, UWIZM Scarabaeidae Beetles)",
 "TaxonKey is Anoplognathus boisduvali Boisduval, 1835"
 ]
}

 The dataset includes 677 records from 9 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0033053-241126133413365/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15161/oar.it/143191
title: Carta Geologica d'Italia alla scala 1:50.000, F. 213-230 Genova

description: Foglio geologico alla scala 1:50.000 basato su rilevamenti alla scala 1:10.000 (eseguiti tra il 1984 e il 1994) comprensivo di legenda, schemi a cornice, sezioni geologiche.
DOI: 10.15161/oar.it/143190
title: Carta Geologica d'Italia alla scala 1:50.000, F. 213-230 Genova

description: Foglio geologico alla scala 1:50.000 basato su rilevamenti alla scala 1:10.000 (eseguiti tra il 1984 e il 1994) comprensivo di legenda, schemi a cornice, sezioni geologiche.
DOI: 10.15468/dl.83meqa
title: Occurrence Download

description: A dataset containing 119 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Atlantidae",
 "Geometry POLYGON((170 20, 170 50, 120 50, 120 20, 170 20))",
 "HasCoordinate is true"
 ]
}

 The dataset includes 119 records from 11 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0033054-241126133413365/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.kgsnv5
title: Occurrence Download

description: A dataset containing 1559839 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Milvus migrans (Boddaert, 1783)"
 ]
}

 The dataset includes 1559839 records from 2099 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0288214-220831081235567/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.gkj9hr
title: Occurrence Download

description: A dataset containing 1 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Hieracium chlorinum Sennikov"
 ]
}

 The dataset includes 1 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0243274-230224095556074/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.svey4r
title: Occurrence Download

description: A dataset containing 67307 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Fraxinus pennsylvanica Marshall",
 "HasCoordinate is true",
 "HasGeospatialIssue is false"
 ]
}

 The dataset includes 67307 records from 304 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0003529-230918134249559/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.b6htjz
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Hiepia corymbosa V.T.Pham & Aver."
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0242609-230224095556074/datasets/export for details.
DOI: 10.15468/dl.hmzsy4
title: Occurrence Download

description: A dataset containing 13 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Hibiscus zygomorphus Fryxell & S.D.Koch"
 ]
}

 The dataset includes 13 records from 12 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0242600-230224095556074/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.dsjs9z
title: Occurrence Download

description: A dataset containing 10 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Hermannia rautanenii Schinz ex K.Schum."
 ]
}

 The dataset includes 10 records from 4 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0241042-230224095556074/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.u3xttp
title: Occurrence Download

description: A dataset containing 612 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Geometry MULTIPOLYGON(((5.43916 43.24565,5.44171 43.23829,5.46778 43.23039,5.47466 43.22449,5.48865 43.226,5.49284 43.23216,5.47758 43.24243,5.44925 43.24777,5.43916 43.24565)))",
 "Year 2013-2023"
 ]
}

 The dataset includes 612 records from 12 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0243276-230224095556074/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.zwepgf
title: Occurrence Download

description: A dataset containing 418219720 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is one of (Attalea brejinhoensis (Glassman) Zona, Attalea speciosa Mart. ex Spreng., Attalea glassmanii Zona, Attalea speciosa Mart., Attalea vitrivir Zona, Orbignya barbosiana Burret, Orbignya brejinhoensis Glassman, Orbignya huebneri Burret, Orbignya lydiae Drude, Orbignya martiana Barb.Rodr., Orbignya oleifera Burret, Orbignya phalerata Mart., Orbignya speciosa (Mart.) Barb.Rodr., Tracheophyta)"
 ]
}

 The dataset includes 418219720 records from 12389 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0003522-230918134249559/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.zngbpu
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Melaleuca alternifolia",
 "Country is India",
 "HasCoordinate is true"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0060971-250920141307145/datasets/export for details.