cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.20522994
title: Predicting compressive strength of concrete with fly ash, metakaolin and silica fume by using machine learning techniques

description: Abstract The compressive strength (CS) is the most important parameter in the design codes of reinforced concrete structures. The development of simple mathematical equations for the prediction of CS of concrete can have many practical advantages such as it save cost and time in experiments needed for suitable design data. Due to environmental concerns with the production of cement, different supplementary cementitious materials are often used as partial replacements for cement such as fly ash (FA), metakaolin (MK), and silica fume (SF). However, little work has been done for developing simple mathematical equations for the prediction of CS with FA, MK and SF by using the M5P algorithm. Moreover, the M5P algorithm is not compared with other modelling techniques such as linear regression analysis, gene expression programming (GEP) and response surface methodology. It is established that, for concrete with FA and SF, M5P showed superior prediction capability as compared with other modelling techniques, however, GEP gave the best performance for concrete with MK: CS decrease by increasing FA content, while it increases by increasing MK and SF content.
DOI: 10.6084/m9.figshare.20522994.v1
title: Predicting compressive strength of concrete with fly ash, metakaolin and silica fume by using machine learning techniques

description: Abstract The compressive strength (CS) is the most important parameter in the design codes of reinforced concrete structures. The development of simple mathematical equations for the prediction of CS of concrete can have many practical advantages such as it save cost and time in experiments needed for suitable design data. Due to environmental concerns with the production of cement, different supplementary cementitious materials are often used as partial replacements for cement such as fly ash (FA), metakaolin (MK), and silica fume (SF). However, little work has been done for developing simple mathematical equations for the prediction of CS with FA, MK and SF by using the M5P algorithm. Moreover, the M5P algorithm is not compared with other modelling techniques such as linear regression analysis, gene expression programming (GEP) and response surface methodology. It is established that, for concrete with FA and SF, M5P showed superior prediction capability as compared with other modelling techniques, however, GEP gave the best performance for concrete with MK: CS decrease by increasing FA content, while it increases by increasing MK and SF content.
DOI: 10.6084/m9.figshare.20484464
title: How to choose initial treatment in multiple sclerosis patients: a case-based approach

description: ABSTRACT Background: Immunotherapy dramatically changed the natural history of multiple sclerosis (MS), which was classically associated with severe disability. Treatment strategies advocate that early control of disease activity is crucial to avoid progressive disability, and the use of high efficacy drugs may be beneficial, but safety is a concern. Choosing the disease-modifying therapy is challenging in clinical practice and should be further discussed. Objective: To discuss the state of art of selecting the initial therapy for relapsing MS patients. Methods: We used a case-based approach followed by clinical discussion, exploring therapeutic options in different MS settings. Results: We presented clinical cases profile compatible with the use of MS therapies, classified into moderate and high efficacy. In the moderate efficacy group, we discussed interferons, glatiramer acetate, teriflunomide and dimethyl fumarate, while in the high efficacy group we discussed fingolimod, cladribine, natalizumab, ocrelizumab, alemtuzumab and ofatumumab. Conclusion: Advances in MS treatment are remarkable. Strong evidence supports the use of early high efficacy therapy. However, biomarkers, clinical and radiologic prognostic factors, as well as patients' individual issues, should be valued and considered for a personalized treatment decision.
DOI: 10.6084/m9.figshare.20484464.v1
title: How to choose initial treatment in multiple sclerosis patients: a case-based approach

description: ABSTRACT Background: Immunotherapy dramatically changed the natural history of multiple sclerosis (MS), which was classically associated with severe disability. Treatment strategies advocate that early control of disease activity is crucial to avoid progressive disability, and the use of high efficacy drugs may be beneficial, but safety is a concern. Choosing the disease-modifying therapy is challenging in clinical practice and should be further discussed. Objective: To discuss the state of art of selecting the initial therapy for relapsing MS patients. Methods: We used a case-based approach followed by clinical discussion, exploring therapeutic options in different MS settings. Results: We presented clinical cases profile compatible with the use of MS therapies, classified into moderate and high efficacy. In the moderate efficacy group, we discussed interferons, glatiramer acetate, teriflunomide and dimethyl fumarate, while in the high efficacy group we discussed fingolimod, cladribine, natalizumab, ocrelizumab, alemtuzumab and ofatumumab. Conclusion: Advances in MS treatment are remarkable. Strong evidence supports the use of early high efficacy therapy. However, biomarkers, clinical and radiologic prognostic factors, as well as patients' individual issues, should be valued and considered for a personalized treatment decision.
DOI: 10.6084/m9.figshare.20522997
title: The efficiency of prechilling and gibberellic acid (GA3) for breaking thermodormancy in lettuce

description: Abstract: The study focused on increasing the germination of lettuce cultivars under high-temperature conditions by seed treatments. The seeds of lettuce cultivars Yedikule, Iceberg, Iri Kıvırcık, and BT Iri Kıvırcık with different leaf morphology were primed by different doses of gibberellic acid (GA3) (0, 250, 500, and 1000 ppm) and preconditioned by chilling and heating. The seeds were germinated at optimal (20 °C) and high (35 °C) temperatures. The results showed that high temperature adversely influenced the germination percentage of lettuce cultivars. The mean germination percentage was 16.8% at 35 °C and 93.4% at 20 °C. Also, there was a significant difference among lettuce cultivars for germination at 35 °C. Iri Kıvırcık and BT Iri Kıvırcık showed a severe thermodormancy and hardly ever germinated at 35 °C. Prechilling and preheating promoted germination at 35 °C compared to unprimed seeds, but prechilling resulted in higher germination than preheating. GA3 was found to be the most useful treatment for improving germination compared to the others. The germination percentage of Iceberg, Yedikule, and Iri Kıvırcık primed with GA3 doses reached over 80%. The results suggested that the germination performance of lettuce cultivars suffering from thermodormancy or wherever climatic conditions with high temperatures should be promoted by the application of 500 ppm de GA3.
DOI: 10.6084/m9.figshare.20522997.v1
title: The efficiency of prechilling and gibberellic acid (GA3) for breaking thermodormancy in lettuce

description: Abstract: The study focused on increasing the germination of lettuce cultivars under high-temperature conditions by seed treatments. The seeds of lettuce cultivars Yedikule, Iceberg, Iri Kıvırcık, and BT Iri Kıvırcık with different leaf morphology were primed by different doses of gibberellic acid (GA3) (0, 250, 500, and 1000 ppm) and preconditioned by chilling and heating. The seeds were germinated at optimal (20 °C) and high (35 °C) temperatures. The results showed that high temperature adversely influenced the germination percentage of lettuce cultivars. The mean germination percentage was 16.8% at 35 °C and 93.4% at 20 °C. Also, there was a significant difference among lettuce cultivars for germination at 35 °C. Iri Kıvırcık and BT Iri Kıvırcık showed a severe thermodormancy and hardly ever germinated at 35 °C. Prechilling and preheating promoted germination at 35 °C compared to unprimed seeds, but prechilling resulted in higher germination than preheating. GA3 was found to be the most useful treatment for improving germination compared to the others. The germination percentage of Iceberg, Yedikule, and Iri Kıvırcık primed with GA3 doses reached over 80%. The results suggested that the germination performance of lettuce cultivars suffering from thermodormancy or wherever climatic conditions with high temperatures should be promoted by the application of 500 ppm de GA3.
DOI: 10.6084/m9.figshare.20484530
title: From clinical phenotype to proteinopathy: molecular neuroimaging in neurodegenerative dementias

description: ABSTRACT Neurodegenerative dementias are characterized by the abnormal accumulation of misfolded proteins. However, its diagnostic criteria are still based on the clinical phenotype. The development of biomarkers allowed in vivo detection of pathophysiological processes. This article aims to make a non-systematic review of the use of molecular neuroimaging as a biomarker. Molecular neuroimaging is based on the use of radiotracers for image acquisition. The radiotracer most used in PET is 18F-fluorodeoxyglucose (FDG), with which it is possible to study the regional brain glucose metabolism. The pattern of regional hypometabolism provides neuroanatomical information on the neurodegenerative process, which, in turn, has a good specificity for each type of proteinopathy. FDG is very useful in the differential diagnosis of neurodegenerative dementias through the regional pattern of involvement, including dementia with Lewy bodies and the spectrum of frontotemporal dementia. More recently, radiotracers with specific ligands to some of the pathological proteins have been developed. Pittsburgh compound B (PIB) labeled with 11C and the ligands that use 18F (florbetapir, florbetaben and flutemetamol) are the most used radiotracers for the detection of insoluble β-amyloid peptide in Alzheimer's disease (AD). A first generation of ligands for tau protein has been developed, but it has some affinity for other non-tau protein aggregates. A second generation has the advantage of having a higher affinity for hyperphosphorylated tau protein, including in primary tauopathies.
DOI: 10.6084/m9.figshare.20484530.v1
title: From clinical phenotype to proteinopathy: molecular neuroimaging in neurodegenerative dementias

description: ABSTRACT Neurodegenerative dementias are characterized by the abnormal accumulation of misfolded proteins. However, its diagnostic criteria are still based on the clinical phenotype. The development of biomarkers allowed in vivo detection of pathophysiological processes. This article aims to make a non-systematic review of the use of molecular neuroimaging as a biomarker. Molecular neuroimaging is based on the use of radiotracers for image acquisition. The radiotracer most used in PET is 18F-fluorodeoxyglucose (FDG), with which it is possible to study the regional brain glucose metabolism. The pattern of regional hypometabolism provides neuroanatomical information on the neurodegenerative process, which, in turn, has a good specificity for each type of proteinopathy. FDG is very useful in the differential diagnosis of neurodegenerative dementias through the regional pattern of involvement, including dementia with Lewy bodies and the spectrum of frontotemporal dementia. More recently, radiotracers with specific ligands to some of the pathological proteins have been developed. Pittsburgh compound B (PIB) labeled with 11C and the ligands that use 18F (florbetapir, florbetaben and flutemetamol) are the most used radiotracers for the detection of insoluble β-amyloid peptide in Alzheimer's disease (AD). A first generation of ligands for tau protein has been developed, but it has some affinity for other non-tau protein aggregates. A second generation has the advantage of having a higher affinity for hyperphosphorylated tau protein, including in primary tauopathies.
DOI: 10.6084/m9.figshare.20522999
title: Relative prices and concentration in the Brazilian industry: analysis of the expansion and retraction phases of economic activity from 1974 to 1994

description: ABSTRACT This paper examines the relative price’s behavior of the Brazilian industry in the phases of expansion and retraction of the economic activity level between 1974-1994. The results suggest that relative prices of the oligopolistic sector accelerate more (less) in periods of recession (expansion) then the competitive sector. The main conclusion is that given the differentiated behavior in the price and low competition of the majority of the Brazilian industry, it is likely that the recession result of a restrict economic policy will be absorbed by the competitive sector “in favour” of the oligopolistic sector.
DOI: 10.6084/m9.figshare.20522999.v1
title: Relative prices and concentration in the Brazilian industry: analysis of the expansion and retraction phases of economic activity from 1974 to 1994

description: ABSTRACT This paper examines the relative price’s behavior of the Brazilian industry in the phases of expansion and retraction of the economic activity level between 1974-1994. The results suggest that relative prices of the oligopolistic sector accelerate more (less) in periods of recession (expansion) then the competitive sector. The main conclusion is that given the differentiated behavior in the price and low competition of the majority of the Brazilian industry, it is likely that the recession result of a restrict economic policy will be absorbed by the competitive sector “in favour” of the oligopolistic sector.
DOI: 10.6084/m9.figshare.20523000
title: Relationship between main reproductive parameters and productivity traits in dairy cows

description: ABSTRACT The objective of this study was to determine relationship between Lithuanian dairy cow breed productive and reproductive traits. The study was carried out with 586 fully completed lactation cows: 184 Lithuanian Holstein (H), 320 Lithuanian Black and White (LBW) and 82 Lithuanian Red (LR) cows (291 cows in I, 149 in II and 146 in III and older lactations). Cow productivity and reproduction traits were calculated. H cows in I lactation had a lower insemination index compared to the LR, shorter calving interval (P≤0.05) and service period (P≤0.05) than LBW cows. LBW cows produced 1440.46kg more milk (P≤0.05) with less milk fat and protein content (accordingly 0.28 and 0.22 percent) (P≤0.05) compared with the LRd. The service period of LBW older lactation cows was 21.38 days longer and the insemination index was 0.68 times higher compared to the I lactation cows (P&lt;0.05). LR cows of III and older lactations produced 3742kg more milk (P≤0.05) compared with the I lactation. All cows from 131 and more service period days produced 1420kg more milk with 0.51 percent less fat (P≤0.05) and 0.1 percent less protein than cows with the service period from 91 till 110 days (P≤0.05).
DOI: 10.6084/m9.figshare.20523000.v1
title: Relationship between main reproductive parameters and productivity traits in dairy cows

description: ABSTRACT The objective of this study was to determine relationship between Lithuanian dairy cow breed productive and reproductive traits. The study was carried out with 586 fully completed lactation cows: 184 Lithuanian Holstein (H), 320 Lithuanian Black and White (LBW) and 82 Lithuanian Red (LR) cows (291 cows in I, 149 in II and 146 in III and older lactations). Cow productivity and reproduction traits were calculated. H cows in I lactation had a lower insemination index compared to the LR, shorter calving interval (P≤0.05) and service period (P≤0.05) than LBW cows. LBW cows produced 1440.46kg more milk (P≤0.05) with less milk fat and protein content (accordingly 0.28 and 0.22 percent) (P≤0.05) compared with the LRd. The service period of LBW older lactation cows was 21.38 days longer and the insemination index was 0.68 times higher compared to the I lactation cows (P&lt;0.05). LR cows of III and older lactations produced 3742kg more milk (P≤0.05) compared with the I lactation. All cows from 131 and more service period days produced 1420kg more milk with 0.51 percent less fat (P≤0.05) and 0.1 percent less protein than cows with the service period from 91 till 110 days (P≤0.05).
DOI: 10.6084/m9.figshare.20523003
title: Copper sulfate and arginine supplements on performance, thyroid hormones and blood biochemistry of broilers fed with canola meal-based diets

description: ABSTRACT: The present evaluated the effects of copper sulfate solution (CSS) and arginine powder (Arg) supplements on performance, thyroid hormones and blood biochemistry of broiler chickens fed with canola meal (CM)-based diets. The experimental design was completely randomized with a 3 × 3 factorial and 9 treatments, corresponding to 3 levels of CSS (0, 125 and 250 mg/kg) and 3 levels of Arg (0, 0.1 and 0.2%) (n = 45 per treatment). Feeds were offered ad libitum for 21 days, from 22 to 42 days of age. Feed efficiency was significantly affected by the dietary addition of 250 mg/kg CSS and 0.2% Arg, and by the CSS × Arg interaction. CM supplemented with CSS improved the thyroid gland status and increased the plasma levels of triiodothyronine and thyroxine. Birds fed diets supplemented with 0.2% Arg had lower blood glucose level than the other treatments. The addition of 250 mg/kg CSS and 0.2% Arg reduced the stress caused by the rapid growth of broilers, also increasing the overall bird welfare.
DOI: 10.6084/m9.figshare.20523003.v1
title: Copper sulfate and arginine supplements on performance, thyroid hormones and blood biochemistry of broilers fed with canola meal-based diets

description: ABSTRACT: The present evaluated the effects of copper sulfate solution (CSS) and arginine powder (Arg) supplements on performance, thyroid hormones and blood biochemistry of broiler chickens fed with canola meal (CM)-based diets. The experimental design was completely randomized with a 3 × 3 factorial and 9 treatments, corresponding to 3 levels of CSS (0, 125 and 250 mg/kg) and 3 levels of Arg (0, 0.1 and 0.2%) (n = 45 per treatment). Feeds were offered ad libitum for 21 days, from 22 to 42 days of age. Feed efficiency was significantly affected by the dietary addition of 250 mg/kg CSS and 0.2% Arg, and by the CSS × Arg interaction. CM supplemented with CSS improved the thyroid gland status and increased the plasma levels of triiodothyronine and thyroxine. Birds fed diets supplemented with 0.2% Arg had lower blood glucose level than the other treatments. The addition of 250 mg/kg CSS and 0.2% Arg reduced the stress caused by the rapid growth of broilers, also increasing the overall bird welfare.
DOI: 10.6084/m9.figshare.20523002
title: Reproductive performance of red-winged tinamous (Rhynchotus rufescens) using different mating strategies in captivity - case report

description: ABSTRACT The aim of this study was to evaluate the reproductive performance of red-winged tinamous in captivity using different mating systems during three breeding seasons. The data were collected from August to March during three breeding seasons of the species. Ten couples and four groups of red-winged tinamous were randomly selected for formation of the monogamous and polygynous mating system, respectively, with egg collection from both systems. The traits evaluated were number of eggs per female, egg breaking and egg fertilization. Data were statistically analyzed by the least square method and logistic regression. Animals in couples mating strategy were superior (P&lt;0.05) in terms of number of eggs per female compared to the group mating strategy. High egg breaking rate (P&lt;0.05) in the red-winged tinamous groups was observed. Eggs of animals in couples mating strategy were 5.24 and 11.5 more likely to be fertilized than those of group strategy in two breeding seasons. In general, the reproductive efficiency in terms of low egg breaking, high egg production and fertility was observed for red-winged tinamous from the monogamous mating system.
DOI: 10.6084/m9.figshare.20523002.v1
title: Reproductive performance of red-winged tinamous (Rhynchotus rufescens) using different mating strategies in captivity - case report

description: ABSTRACT The aim of this study was to evaluate the reproductive performance of red-winged tinamous in captivity using different mating systems during three breeding seasons. The data were collected from August to March during three breeding seasons of the species. Ten couples and four groups of red-winged tinamous were randomly selected for formation of the monogamous and polygynous mating system, respectively, with egg collection from both systems. The traits evaluated were number of eggs per female, egg breaking and egg fertilization. Data were statistically analyzed by the least square method and logistic regression. Animals in couples mating strategy were superior (P&lt;0.05) in terms of number of eggs per female compared to the group mating strategy. High egg breaking rate (P&lt;0.05) in the red-winged tinamous groups was observed. Eggs of animals in couples mating strategy were 5.24 and 11.5 more likely to be fertilized than those of group strategy in two breeding seasons. In general, the reproductive efficiency in terms of low egg breaking, high egg production and fertility was observed for red-winged tinamous from the monogamous mating system.
DOI: 10.6084/m9.figshare.20484593
title: Are we ready to use anti-amyloid therapy in Alzheimer's disease?

description: ABSTRACT Alzheimer’s disease (AD) is the most common neurodegenerative disease. Biomarkers have demonstrated that AD pathology exists over the disease continuum from a stage preceding symptoms over 15-25 years to the progressively more impaired symptomatic states, mild cognitive impairment (MCI), and dementia. Biomarkers include: amyloid (Aß), phosphorylated tau, and neurodegeneration. The plasma assays for Aß and tau show great promise for clinical and research use. This review has aimed not only to present the ATN diagnostic classification and the preclinical AD concepts in addressing some possibilities of cognitive assessment instruments, but also to briefly summarize the main anti-amyloid monoclonal antibodies studied in clinical trials. In addition, this paper presents a critical analysis by experts in cognitive neurology while addressing the question as to whether we are prepared for the anti-amyloid therapy era or not.
DOI: 10.6084/m9.figshare.20484593.v1
title: Are we ready to use anti-amyloid therapy in Alzheimer's disease?

description: ABSTRACT Alzheimer’s disease (AD) is the most common neurodegenerative disease. Biomarkers have demonstrated that AD pathology exists over the disease continuum from a stage preceding symptoms over 15-25 years to the progressively more impaired symptomatic states, mild cognitive impairment (MCI), and dementia. Biomarkers include: amyloid (Aß), phosphorylated tau, and neurodegeneration. The plasma assays for Aß and tau show great promise for clinical and research use. This review has aimed not only to present the ATN diagnostic classification and the preclinical AD concepts in addressing some possibilities of cognitive assessment instruments, but also to briefly summarize the main anti-amyloid monoclonal antibodies studied in clinical trials. In addition, this paper presents a critical analysis by experts in cognitive neurology while addressing the question as to whether we are prepared for the anti-amyloid therapy era or not.