cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.21835180.v1
title: Glyceryl behenate-based solid lipid nanoparticles as a carrier of haloperidol for nose to brain delivery: formulation development, in-vitro, and in-vivo evaluation

description: Abstract This study was aimed to develop the haloperidol (HPL) loaded solid lipid nanoparticles (SLNs) for brain targeting through the intranasal route. SLNs were fabricated by the emulsification diffusion technique using glyceryl behenate as lipid and tween 80 as a surfactant. SLNs were evaluated for particle size, zeta potential, structure, entrapment efficiency, solid state characterization by differential scanning calorimetry (DSC), and in-vitro release. In-vivo biological evaluation was performed on albino Wistar rats for the determination of pharmacokinetic as well as brain targeting parameters. Particle size, PDI, zeta potential, and entrapment efficiency of optimized formulation (HPL-SLNs 6) were found to be 103±09 nm, 0.190±0.029, -23.5±1.07 mV, and 79.46±1.97% respectively. In-vitro drug release studies exhibited that 87.21± 3.63% of the entrapped drug was released from the SLNs within 24 h. DSC curves confirmed that during entrapment in SLNs, the drug was solubilized in the lipid matrix and converted into the amorphous form. Enhanced HPL targeting to the brain was observed from HPL-SLNs as compared to HPL-Sol when administered intranasally. The value of AUC 0-∞ in the brain for HPL-SLNs i.n. was found to be nearly 2.7 times higher than that of HPL-Sol i.v., whereas 3.66 times superior to HPL-Sol administered i.n. Stability studies revealed that the formulation remains unchanged when stored at 4±2 °C (refrigerator) and 25±2 °C /60 ±5% RH up to six months. Finally, it could be concluded that SLN is a suitable carrier for HPL with enhanced brain targeting through i.n administration, as compared to the HPL-Sol, administered i.n. and i.v.
DOI: 10.6084/m9.figshare.21835183
title: Phenolic Compounds from Leaves of Cariniana estrellensis (Raddi) Kuntze (Lecythidaceae): A Brazilian Atlantic Forest Tree

description: Cariniana estrellensis (Raddi) Kuntze seedlings have been used in forest restoration programs in the Atlantic Forest biome. However, despite the economic and ecological relevance of this species, to date no general method for rapid identification of primary and secondary metabolites of C. estrellensis leaves has been reported. In this work, we explore the feasibility of using rapid analysis by nuclear magnetic resonance techniques and liquid chromatography coupled to diode array, charged aerosol, and mass detection. The main secondary metabolites identified were hydrolysable tannins, quinic acid, hydroxycinnamic acids (trans-p-coumaric acid, cis p coumaric acid, and trans-ferulic acid), and flavonoids (kaempferol and quercetin derivatives). These compounds are particularly useful as chemotaxonomic markers for the genus Cariniana and for the family Lecythidaceae, and may also be important for pharmacological uses and for the survival of the seedlings in reforestation programs.
DOI: 10.6084/m9.figshare.21835183.v1
title: Phenolic Compounds from Leaves of Cariniana estrellensis (Raddi) Kuntze (Lecythidaceae): A Brazilian Atlantic Forest Tree

description: Cariniana estrellensis (Raddi) Kuntze seedlings have been used in forest restoration programs in the Atlantic Forest biome. However, despite the economic and ecological relevance of this species, to date no general method for rapid identification of primary and secondary metabolites of C. estrellensis leaves has been reported. In this work, we explore the feasibility of using rapid analysis by nuclear magnetic resonance techniques and liquid chromatography coupled to diode array, charged aerosol, and mass detection. The main secondary metabolites identified were hydrolysable tannins, quinic acid, hydroxycinnamic acids (trans-p-coumaric acid, cis p coumaric acid, and trans-ferulic acid), and flavonoids (kaempferol and quercetin derivatives). These compounds are particularly useful as chemotaxonomic markers for the genus Cariniana and for the family Lecythidaceae, and may also be important for pharmacological uses and for the survival of the seedlings in reforestation programs.
DOI: 10.6084/m9.figshare.21835185
title: Environmental factors associated with excessive gestational weight gain: a meta-analysis and systematic review

description: Abstract The aim is, systematically examine the scientific evidences that associated environmental factors (environment, social environment, environmental planning and spatial population distribution) with the excessive gestational weight gain. A meta-analysis and systematic review carried out as per the Cochrane Handbook recommendations and following the steps recommended by the Preferred Reporting Items for Systematic Reviews and Meta-Analyzes. The inclusion studies were done with the following PECO criteria: P-pregnant women, E-environmental factors, O-weight gain. The search procedure was conducted on the databases EMBASE, Web of Science, Cinahl, LILACS and MEDLINE (PubMed). The relationship between the socioeconomic factors of the micro-region of residence and gestational weight gain was evidenced by the linkage between residing in high-poverty neighborhoods and inadequate gestational weight gain. This study revealed the higher prevalence of excessive gestational weight gain in pregnant women those lives in urban areas. Environmental factors of the pregnant women’s residence area implicated in the excessive gestational weight gain. Our findings can therefore contribute to the development of public policies to prevent inadequate gestational weight gain.
DOI: 10.6084/m9.figshare.21835185.v1
title: Environmental factors associated with excessive gestational weight gain: a meta-analysis and systematic review

description: Abstract The aim is, systematically examine the scientific evidences that associated environmental factors (environment, social environment, environmental planning and spatial population distribution) with the excessive gestational weight gain. A meta-analysis and systematic review carried out as per the Cochrane Handbook recommendations and following the steps recommended by the Preferred Reporting Items for Systematic Reviews and Meta-Analyzes. The inclusion studies were done with the following PECO criteria: P-pregnant women, E-environmental factors, O-weight gain. The search procedure was conducted on the databases EMBASE, Web of Science, Cinahl, LILACS and MEDLINE (PubMed). The relationship between the socioeconomic factors of the micro-region of residence and gestational weight gain was evidenced by the linkage between residing in high-poverty neighborhoods and inadequate gestational weight gain. This study revealed the higher prevalence of excessive gestational weight gain in pregnant women those lives in urban areas. Environmental factors of the pregnant women’s residence area implicated in the excessive gestational weight gain. Our findings can therefore contribute to the development of public policies to prevent inadequate gestational weight gain.
DOI: 10.6084/m9.figshare.21835188
title: Leprosy and vulnerability: a scoping review

description: Abstract The objective of this work was to review published scientific works on leprosy as a public health problem in Brazil, and the marker of vulnerability for people with the disease. A scoping review was carried out with the descriptor ‘leprosy AND vulnerability’, on the Virtual Health Library (BVS) database. A total of 29 articles published between January 2016 and December 2020 that met the inclusion criteria were selected. The results pointed to scientific papers published in indexed journals and with different impact factors, with emphasis on the fact that most of the selected publications appear in journals with impact metrics that are not very significant in the eyes of the international community, even though they have national impact. The majority of the studies had municipal coverage, with emphasis on cities in the North and Northeast of Brazil. The works addressed vulnerability in leprosy using different typologies.
DOI: 10.6084/m9.figshare.21835188.v1
title: Leprosy and vulnerability: a scoping review

description: Abstract The objective of this work was to review published scientific works on leprosy as a public health problem in Brazil, and the marker of vulnerability for people with the disease. A scoping review was carried out with the descriptor ‘leprosy AND vulnerability’, on the Virtual Health Library (BVS) database. A total of 29 articles published between January 2016 and December 2020 that met the inclusion criteria were selected. The results pointed to scientific papers published in indexed journals and with different impact factors, with emphasis on the fact that most of the selected publications appear in journals with impact metrics that are not very significant in the eyes of the international community, even though they have national impact. The majority of the studies had municipal coverage, with emphasis on cities in the North and Northeast of Brazil. The works addressed vulnerability in leprosy using different typologies.
DOI: 10.6084/m9.figshare.21835189
title: THE USE OF BLACKFACE AS A PEDAGOGICAL PRACTICE IN THE EARLY YEARS OF BASIC EDUCATION

description: ABSTRACT This work aims to reflect the pedagogical practices that use blackface, in the wrong way, in the search for the valorization of Afro-Brazilian and African history and culture. To achieve this goal we used as theoretical contribution Munanga (2008), Hall (2016), Souza (2011) and Silva (2014). The methodology used was the qualitative analysis of structured and semi-structured interviews with teachers in the Early Childhood and Elementary Education segment I. Finally, it was understood that teachers do not know what blackface is about, even practicing, because this is the result of a formation with eurocentric curriculum that reproduces a racist discourse and without the information on the subject continue to be engendered in schools, “consumed” by students and reproduced by them also, in a continuous cycle of repetition, whose interruption will only be made possible with the implementation of anti-racist practices that are in accordance with Law 10.639/2003 and its Guidelines (2004).
DOI: 10.6084/m9.figshare.21835189.v1
title: THE USE OF BLACKFACE AS A PEDAGOGICAL PRACTICE IN THE EARLY YEARS OF BASIC EDUCATION

description: ABSTRACT This work aims to reflect the pedagogical practices that use blackface, in the wrong way, in the search for the valorization of Afro-Brazilian and African history and culture. To achieve this goal we used as theoretical contribution Munanga (2008), Hall (2016), Souza (2011) and Silva (2014). The methodology used was the qualitative analysis of structured and semi-structured interviews with teachers in the Early Childhood and Elementary Education segment I. Finally, it was understood that teachers do not know what blackface is about, even practicing, because this is the result of a formation with eurocentric curriculum that reproduces a racist discourse and without the information on the subject continue to be engendered in schools, “consumed” by students and reproduced by them also, in a continuous cycle of repetition, whose interruption will only be made possible with the implementation of anti-racist practices that are in accordance with Law 10.639/2003 and its Guidelines (2004).
DOI: 10.6084/m9.figshare.21835191
title: Prevention and control of oral cancer: contribution of the Bipartite Inter-Managers Commission in the state of Rio de Janeiro

description: ABSTRACT Expanding access to oral cancer prevention and control requires constructing an inter-municipal care network. The Bipartite Intermanagement Commission (CIB) plays a central role in this process. This study aims to analyze, from the perspective of the Structuring Theory, the participation of the CIB in structuring oral cancer prevention and control actions within the scope of the Unified Health System, in the state of Rio de Janeiro, Brazil. This exploratory case study analyzes documents from the CIB of Rio de Janeiro between 1996 and 2019. Data collection and extraction took place in the first quarter of 2020. Two researchers individually analyzed the content of 739 documents in the categories: Constitution of the health network; Financing of health actions; Professional qualification in health. Discussions at the CIB proved to be limited, due to the more municipal and less regionalized characteristics adopted by the state for oral health. Access to treatment gave rise to debates that contributed to the expansion of the hospital network and the reorganization of regulation, even if limited. This formal space for inter-manager negotiation and decision-making has become a merely informative or pro forma deliberative space, which brings limitations to the structuring of regional actions for the prevention and control of oral cancer in the state of Rio de Janeiro.
DOI: 10.6084/m9.figshare.21835191.v1
title: Prevention and control of oral cancer: contribution of the Bipartite Inter-Managers Commission in the state of Rio de Janeiro

description: ABSTRACT Expanding access to oral cancer prevention and control requires constructing an inter-municipal care network. The Bipartite Intermanagement Commission (CIB) plays a central role in this process. This study aims to analyze, from the perspective of the Structuring Theory, the participation of the CIB in structuring oral cancer prevention and control actions within the scope of the Unified Health System, in the state of Rio de Janeiro, Brazil. This exploratory case study analyzes documents from the CIB of Rio de Janeiro between 1996 and 2019. Data collection and extraction took place in the first quarter of 2020. Two researchers individually analyzed the content of 739 documents in the categories: Constitution of the health network; Financing of health actions; Professional qualification in health. Discussions at the CIB proved to be limited, due to the more municipal and less regionalized characteristics adopted by the state for oral health. Access to treatment gave rise to debates that contributed to the expansion of the hospital network and the reorganization of regulation, even if limited. This formal space for inter-manager negotiation and decision-making has become a merely informative or pro forma deliberative space, which brings limitations to the structuring of regional actions for the prevention and control of oral cancer in the state of Rio de Janeiro.
DOI: 10.6084/m9.figshare.21835192
title: Temporary reduction of digestible lysine in nursery pig diets: performance and economic analysis

description: ABSTRACT To evaluate the effects of temporary dietary lysine restriction on nursery pigs’ growth performance and its economic viability compared to control diets, 144 piglets (21-d-old) were assigned to randomized blocks, with two treatments and twelve replicates. The treatments were control-lys: lysine level as recommended from 21-32 and 32-42 days and low-lys: 90% of the lysine level of the control-lys diets. From 42 to 62 days, all animals received a control diet. From 21 to 32 days, pigs fed low-lys had worse average daily gain (ADG), feed conversion, and 32-d body weight (BW; P ≤ 0.05). From 32 to 42 days, pigs fed low-lys had lower average daily feed intake, ADG, and 42-d BW (P ≤ 0.05). From 42 to 62 days, pigs had similar performance (P &gt; 0.05). Overall (21 to 62 days), pigs fed the low-lys had lower (P &lt;0.05) ADG and final BW. At 27 and 29 days, pigs fed the low-lys diet had a higher (P≤0.05) incidence of diarrhea. The lowest feed cost and the highest economic efficiency index were recorded for the low-lys treatment. However, pigs fed the control-lys presented a 3.9% higher profitability. In conclusion, a temporary reduction of lysine in the diets of nursery pigs followed by an unrestricted diet in the subsequent period led to worse growth performance and lower economic viability.
DOI: 10.6084/m9.figshare.21835192.v1
title: Temporary reduction of digestible lysine in nursery pig diets: performance and economic analysis

description: ABSTRACT To evaluate the effects of temporary dietary lysine restriction on nursery pigs’ growth performance and its economic viability compared to control diets, 144 piglets (21-d-old) were assigned to randomized blocks, with two treatments and twelve replicates. The treatments were control-lys: lysine level as recommended from 21-32 and 32-42 days and low-lys: 90% of the lysine level of the control-lys diets. From 42 to 62 days, all animals received a control diet. From 21 to 32 days, pigs fed low-lys had worse average daily gain (ADG), feed conversion, and 32-d body weight (BW; P ≤ 0.05). From 32 to 42 days, pigs fed low-lys had lower average daily feed intake, ADG, and 42-d BW (P ≤ 0.05). From 42 to 62 days, pigs had similar performance (P &gt; 0.05). Overall (21 to 62 days), pigs fed the low-lys had lower (P &lt;0.05) ADG and final BW. At 27 and 29 days, pigs fed the low-lys diet had a higher (P≤0.05) incidence of diarrhea. The lowest feed cost and the highest economic efficiency index were recorded for the low-lys treatment. However, pigs fed the control-lys presented a 3.9% higher profitability. In conclusion, a temporary reduction of lysine in the diets of nursery pigs followed by an unrestricted diet in the subsequent period led to worse growth performance and lower economic viability.
DOI: 10.6084/m9.figshare.21835195
title: Can quality of education be demanded from the Tutelage Council?

description: ABSTRACT The aim of this paper was to analyze whether the quality of education can be demanded from the Tutelage Council (Conselho Tutelar). It is a qualitative research based on documents regarding the protective practice developed by the Tutelage Council for the effectiveness of educational quality. Data registered in the Information System for Children and Adolescents (Sistema de Informação para a Infância e Adolescência - SIPIA) regarding educational rights violated in Pernambuco, Brazil, were examined, which were treated in the light of the categorical analysis of content. The text was based on the debate held since 1990 on the quality of education, which coincides with the universal access to school, as well as with the social demands for the effective protection of children and adolescents. It was concluded that the lack of quality in terms of the practices carried out in the school routine represents a violation of educational rights enshrined in the Statute of Children and Adolescents (Estatuto da Criança e do Adolescente - ECA), even 30 years after its promulgation. Therefore, it is necessary to demand quality education in a social justice perspective, as this quality is still far from being achieved.
DOI: 10.6084/m9.figshare.21835195.v1
title: Can quality of education be demanded from the Tutelage Council?

description: ABSTRACT The aim of this paper was to analyze whether the quality of education can be demanded from the Tutelage Council (Conselho Tutelar). It is a qualitative research based on documents regarding the protective practice developed by the Tutelage Council for the effectiveness of educational quality. Data registered in the Information System for Children and Adolescents (Sistema de Informação para a Infância e Adolescência - SIPIA) regarding educational rights violated in Pernambuco, Brazil, were examined, which were treated in the light of the categorical analysis of content. The text was based on the debate held since 1990 on the quality of education, which coincides with the universal access to school, as well as with the social demands for the effective protection of children and adolescents. It was concluded that the lack of quality in terms of the practices carried out in the school routine represents a violation of educational rights enshrined in the Statute of Children and Adolescents (Estatuto da Criança e do Adolescente - ECA), even 30 years after its promulgation. Therefore, it is necessary to demand quality education in a social justice perspective, as this quality is still far from being achieved.
DOI: 10.6084/m9.figshare.20035972
title: Therapeutic obstinacy: when medical intervention hurts human dignity

description: Abstract The possibilities offered by technoscience turned therapeutic obstinacy into a frequent occurrence. Seeking to avoid this practice, health professionals experience ethical dilemmas of maintenance or suspension of treatments considered useless. This study describes the health professional’s perception of dysthanasia and reflects on bioethical aspects involved in issues inherent to human beings. This is an integrative literature review carried out from articles published in the scientific databases SciELO and BVSalud, from 2010 to 2020. Palliative care and bioethical principles are the main allies for the recovery of a patient’s dignity, requiring specific legislation to support the professional and the patient. Dysthanasia consists of prolonging the life of patients considered incurable, which, in addition to not being in accordance with the principle of beneficence, results in maleficence due to exposure of the patient to a high incidence of pain and discomfort.
DOI: 10.6084/m9.figshare.20035972.v1
title: Therapeutic obstinacy: when medical intervention hurts human dignity

description: Abstract The possibilities offered by technoscience turned therapeutic obstinacy into a frequent occurrence. Seeking to avoid this practice, health professionals experience ethical dilemmas of maintenance or suspension of treatments considered useless. This study describes the health professional’s perception of dysthanasia and reflects on bioethical aspects involved in issues inherent to human beings. This is an integrative literature review carried out from articles published in the scientific databases SciELO and BVSalud, from 2010 to 2020. Palliative care and bioethical principles are the main allies for the recovery of a patient’s dignity, requiring specific legislation to support the professional and the patient. Dysthanasia consists of prolonging the life of patients considered incurable, which, in addition to not being in accordance with the principle of beneficence, results in maleficence due to exposure of the patient to a high incidence of pain and discomfort.
DOI: 10.6084/m9.figshare.21835197
title: Body-map storytelling: case study on the living and care of women with HIV

description: ABSTRACT The objective of the study was to understand the living and health care of women living with HIV/AIDS, identifying potentialities and challenges, understanding the effects on living with HIV/AIDS in the daily lives of these women and the relationships with the health care network in Porto Alegre. The municipality has HIV/AIDS detection rates six times higher than the national rates and in 2019 reached 17.6 cases/1,000 live births. A descriptive exploratory study was carried out, of the case study type, and the production of data used the construction of a narrated body map. Four women with a confirmed diagnosis of HIV/AIDS, linked to to a primary health care in the city of Porto Alegre, Rio Grande do Sul, participated. Body maps and narratives made it possible to discover a universe populated by stigma, prejudice, fears, and insecurities. The production of health care for women living with HIV/Aids requires the participation of different fields of knowledge, a wide and planned performance of professionals, and, therefore, the construction of care itineraries that meet the demands of these people in a humanized and welcoming way, as well as through public policies that strengthen the health care network to face stigma and prejudice.