cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.23656629
title: Trace elements in the cervical mucus of copper intrauterine device users and non-users (DATA).xlsx

description: Measurements of trace element concentrations in the cervical mucus of women with and without copper IUDs.
DOI: 10.6084/m9.figshare.23656629.v1
title: Trace elements in the cervical mucus of copper intrauterine device users and non-users (DATA).xlsx

description: Measurements of trace element concentrations in the cervical mucus of women with and without copper IUDs.
DOI: 10.5281/zenodo.8132461
title: Dataset and fitting methods for Kinetic Proofreading can Enhance Single Nucleotide Discrimination in a Non-enzymatic DNA Strand Displacement Network

description: This upload contains raw experimental data and the fitting methods used for the article "Kinetic Proofreading can Enhance Single Nucleotide Discrimination in a Non-enzymatic DNA Strand Displacement Network".
DOI: 10.5281/zenodo.8132460
title: Dataset and fitting methods for Kinetic Proofreading can Enhance Single Nucleotide Discrimination in a Non-enzymatic DNA Strand Displacement Network

description: This upload contains raw experimental data and the fitting methods used for the article "Kinetic Proofreading can Enhance Single Nucleotide Discrimination in a Non-enzymatic DNA Strand Displacement Network".
DOI: 10.5281/zenodo.8132463
title: Social interactions differ in their impact on foraging decisions

description: Data and code for the manuscript: Social interactions differ in their impact on foraging decisions
DOI: 10.5281/zenodo.8132462
title: Social interactions differ in their impact on foraging decisions

description: Data and code for the manuscript: Social interactions differ in their impact on foraging decisions
DOI: 10.5281/zenodo.8132333
title: Interpolation of the median grain size of the first 2 cm sediment layer in the former saltworks of Salin de Giraud in 2017

description: Sediment samples were collected in the summer of 2017 over the entire study area at 500 m spacing and in the channels. Grain size analysis of the collected sediment samples was conducted using a Malvern Mastersizer 2000© laser beam grain sizer. The median grain size (d50 in µm) at each sample location was then interpolated over the entire study area. Interpolation was made with the SAGA-GIS software (version 7.9.0). According to the cross-validation error, the best method for the D50mm interpolation was the Modified Quadratic Shepard. The 10-fold validation provided an R² of 0.93, an NMRSE of 24.5, an RMSE of 83.9, an MRE of 7039 with the fit set to “node”, the quadratic neighbours and weighting neighbours set to 50 and the spatial resolution was set to 10 m. The resultant interpolation map was then categorized following the nomenclature of Blott and Pye (2001) provided in the file style_sediment_map.qml.
DOI: 10.5281/zenodo.8132332
title: Interpolation of the median grain size of the first 2 cm sediment layer in the former saltworks of Salin de Giraud in 2017

description: Sediment samples were collected in the summer of 2017 over the entire study area at 500 m spacing and in the channels. Grain size analysis of the collected sediment samples was conducted using a Malvern Mastersizer 2000© laser beam grain sizer. The median grain size (d50 in µm) at each sample location was then interpolated over the entire study area. Interpolation was made with the SAGA-GIS software (version 7.9.0). According to the cross-validation error, the best method for the D50mm interpolation was the Modified Quadratic Shepard. The 10-fold validation provided an R² of 0.93, an NMRSE of 24.5, an RMSE of 83.9, an MRE of 7039 with the fit set to “node”, the quadratic neighbours and weighting neighbours set to 50 and the spatial resolution was set to 10 m. The resultant interpolation map was then categorized following the nomenclature of Blott and Pye (2001) provided in the file style_sediment_map.qml.
DOI: 10.25345/c59s1kw28
title: MassIVE MSV000092392 - 20230710_Cope_Fecal_Negative_Mode_RPC18
title: Mouse fecal samples from WT vs. 3xTg-AD model of Alzheimer's were analyzed on Q Exactive HF in negative ionization mode using reverse phase C18 after extraction with water/methanol.
DOI: 10.5519/qd.zzhs6vi1
title: Query on the Natural History Museum Data Portal (data.nhm.ac.uk) (2 records)
DOI: 10.18112/openneuro.ds004327.v1.0.1
title: Odor imagery but not perception drives risk for food cue reactivity and adiposity
DOI: 10.5066/p99nukix
title: MODFLOW-NWT and MT3D-USGS models for appraising parameter sensitivity and other controlling factors in a synthetic watershed accounting for variably-saturated flow processes

description: A 3-dimensional (3D) synthetic model, using MODFLOW-NWT and MT3D-USGS, explores the new unsaturated zone heat transport capabilities in MT3D-USGS. Model simulations were used to explore various parameter sensitivities and unsaturated zone thicknesses and their impact on heat transport as water enters the subsurface as infiltration, flows through the unsaturated zone to the water table, and eventually exits the groundwater system as discharge to surface-water bodies. The 3D-model is patterned after a real-world watershed located in a region with a temperate, humid climate. Twenty-seven model simulations are included in this data release with the primary distinction between them the thickness of the unsaturated zone. Most model simulations either have a moderately think unsaturated zone or thick unsaturated zone. A small subset of model simulations do not simulate the downward movement of infiltration through the unsaturated zone but apply infiltration directly to the water table using the recharge (RCH) package. Twelve sensitivity run are included in the data release to help illuminate which parameters are important when engaged in heat transport simulation. This investigation begins to explore the impacts of a warming climate on groundwater temperature and ultimately on the temperature of groundwater discharge back to surface-water bodies. The synthetic model evaluated is a necessary first step to real-world applications that are more complicated by nature's heterogeneity. Temperatures simulated by MT3D-USGS were previously verified by comparing output from detailed 1-dimensional models to VS2DH output (https://doi.org/10.1111/gwat.13256). This USGS data release contains the input and output data files for the model simulations described in the associated journal article (https://doi.org/10.3390/w14233883). Model input files were developed from published information; no new datasets were collected as part of the modeling study associated with this data release. Details on data input sources and on processing of input and output files are documented in the associated journal article.
DOI: 10.5281/zenodo.8122234
title: Effect of burosumab on muscle function and strength, and rates of ATP synthesis in skeletal muscle in adults with X-linked Hypophosphatemia

description: <strong>Abstract</strong> <strong>Context: </strong>Burosumab, a neutralizing antibody to FGF23, is approved for the treatment of X-linked hypophosphatemia. In clinical trials burosumab improves symptoms of pain, fatigue and stiffness and improves performance on certain muscle function studies. <strong>Objective: </strong>Determine if burosumab would increase ATP synthesis in skeletal muscle of treatment-naïve adults with XLH and if so whether that correlated with improved muscle function. <strong>Methods: </strong>Ten symptomatic adults, who had not received any treatment for XLH for years, had ATP synthesis rates assessed in the soleus/gastrocnemius muscle complex of the right calf using the <sup>31</sup>P magnetic resonance spectroscopy saturation transfer technique. Baseline muscle function tests and symptoms of pain, fatigue, stiffness and lower extremity joint pain were quantified. All participants were treated with burosumab, 1 mg/kg every four weeks for 12 weeks. ATP synthesis rates and muscle function tests were repeated 2-weeks (“peak”) and 4-weeks (“trough”) after the third dose of burosumab. <strong>Results: </strong>Pain, fatigue, stiffness and lower extremity joint pain all improved with treatment. Performance on the 6-Minute Walk and Sit to Stand tests also improved significantly. Performance on the Timed Up and Go test did not significantly improve (p = 0.057). Muscle strength, measured by dynamometry, did not change significantly in either the upper or lower extremities during the study. ATP synthesis rates did not change over the three months of study in the group as whole. In a sub-analysis comparing individuals whose performances on the 6-Minute Walk Test and Sit to Stand tests were at or better than the mean outcome for those tests, to those whose outcomes were below the mean, no difference was observed in the rate of change in ATP synthesis rates. Despite profound and prolonged hypophosphatemia at baseline, intracellular muscle concentrations of phosphorus were normal. <strong>Conclusion: </strong>The improvement in the 6-Minute Walk Test and Sit to Stand tests without any observed change in either upper or lower extremity muscle strength or ATP synthesis rates, suggests that improvement in pain, fatigue and stiffness may explain, at least in part, the improved performance on these two tests. The preserved intracellular phosphate levels suggests that adaptive mechanisms are present in skeletal muscle that insulate intracellular phosphorus from life-long FGF23-mediaed hypophosphatemia.
DOI: 10.5281/zenodo.8122233
title: Effect of burosumab on muscle function and strength, and rates of ATP synthesis in skeletal muscle in adults with X-linked Hypophosphatemia

description: <strong>Abstract</strong> <strong>Context: </strong>Burosumab, a neutralizing antibody to FGF23, is approved for the treatment of X-linked hypophosphatemia. In clinical trials burosumab improves symptoms of pain, fatigue and stiffness and improves performance on certain muscle function studies. <strong>Objective: </strong>Determine if burosumab would increase ATP synthesis in skeletal muscle of treatment-naïve adults with XLH and if so whether that correlated with improved muscle function. <strong>Methods: </strong>Ten symptomatic adults, who had not received any treatment for XLH for years, had ATP synthesis rates assessed in the soleus/gastrocnemius muscle complex of the right calf using the <sup>31</sup>P magnetic resonance spectroscopy saturation transfer technique. Baseline muscle function tests and symptoms of pain, fatigue, stiffness and lower extremity joint pain were quantified. All participants were treated with burosumab, 1 mg/kg every four weeks for 12 weeks. ATP synthesis rates and muscle function tests were repeated 2-weeks (“peak”) and 4-weeks (“trough”) after the third dose of burosumab. <strong>Results: </strong>Pain, fatigue, stiffness and lower extremity joint pain all improved with treatment. Performance on the 6-Minute Walk and Sit to Stand tests also improved significantly. Performance on the Timed Up and Go test did not significantly improve (p = 0.057). Muscle strength, measured by dynamometry, did not change significantly in either the upper or lower extremities during the study. ATP synthesis rates did not change over the three months of study in the group as whole. In a sub-analysis comparing individuals whose performances on the 6-Minute Walk Test and Sit to Stand tests were at or better than the mean outcome for those tests, to those whose outcomes were below the mean, no difference was observed in the rate of change in ATP synthesis rates. Despite profound and prolonged hypophosphatemia at baseline, intracellular muscle concentrations of phosphorus were normal. <strong>Conclusion: </strong>The improvement in the 6-Minute Walk Test and Sit to Stand tests without any observed change in either upper or lower extremity muscle strength or ATP synthesis rates, suggests that improvement in pain, fatigue and stiffness may explain, at least in part, the improved performance on these two tests. The preserved intracellular phosphate levels suggests that adaptive mechanisms are present in skeletal muscle that insulate intracellular phosphorus from life-long FGF23-mediaed hypophosphatemia.
DOI: 10.6084/m9.figshare.23649786.v15
title: Datasets by figure

description: Here are the original datasets corresponding to each of the figures of the publication. Some datasets are not fully uploaded due to limitations in the size of the storage, but they are available upon request from the authors.
DOI: 10.5281/zenodo.8126450
title: Seismic Signatures of the 12C(α, γ)16O Reaction Rate in White Dwarf Models with Overshooting

description: This data set has all necessary files and scripts to reproduce figures 1-8 in our accepted manuscript.
description: This research is supported by NASA under the Astrophysics Theory Program grant NNH21ZDA001N-ATP, and in part by the National Science Foundation under Grant No. NSF PHY-1748958. This research made extensive use of the SAO/NASA Astrophysics Data System (ADS).
DOI: 10.5281/zenodo.8126449
title: Seismic Signatures of the 12C(α, γ)16O Reaction Rate in White Dwarf Models with Overshooting

description: This data set has all necessary files and scripts to reproduce figures 1-8 in our accepted manuscript.
description: This research is supported by NASA under the Astrophysics Theory Program grant NNH21ZDA001N-ATP, and in part by the National Science Foundation under Grant No. NSF PHY-1748958. This research made extensive use of the SAO/NASA Astrophysics Data System (ADS).
DOI: 10.5281/zenodo.6779983
title: On Trapped Modes In Variable White Dwarfs As Probes Of The 12C(α, γ)16O Reaction Rate

description: The files in this dataset should have everything to re-produce figure 10, the summary plot in the manuscript.
description: We will include all necessary files to reproduce figures 1-10 upon article acceptance.
DOI: 10.5281/zenodo.6472752
title: On Trapped Modes In Variable White Dwarfs As Probes Of The 12C(α, γ)16O Reaction Rate

description: The files in this dataset should have everything to re-produce figure 10, the summary plot in the manuscript.
description: We will include all necessary files to reproduce figures 1-10 upon article acceptance.
DOI: 10.25934/pr00008697
title: Understanding frailty, multimorbidity and renal failure in clinical trials: Attrition, retention and heterogeneity of treatment effects

description: Clinical trials are the key method for determining treatment effects, but are known to be unrepresentative with respect to a range of important clinical characteristics such as age, kidney function, race/ethnicity, multimorbidity and frailty. Declining kidney function is associated both with increasing age and multimorbidity and has important additional implications for drug selection and dosing which are not adequately considered in the clinical trial setting.

We have previously made a number of important observations regarding trials and representativeness. First, multimorbidity and frailty are present (albeit underrepresented) in clinical trials and both predict serious adverse event rates (Hanlon 2019, Hanlon 2021 and Hanlon 2022). Secondly, morbidity count (a metric of multimorbidity) is not associated with heterogeneity in treatment effects (File attachments), but is associated with increased rates of trial attrition (failure for any reason to complete the final trial visit, including intentional and non-intentional withdrawals) (Lees 2022). Finally, clinical trials can be calibrated to real-world populations in order to improve the representativeness of trial findings (Butterly 2022).

However, while these findings are novel, they are difficult to operationalise. We intend to take these findings in three directions. First, we wish to better understand the relationship between frailty and kidney function and trial outcomes and characteristics. Secondly, we wish to determine whether it is practical to increase trial representativeness by recruiting more individuals with frailty, multimorbidity and impaired kidney function, or whether this would simply lead to greater trial attrition. Thirdly, we wish to determine whether calibrating trials to target populations modifies treatment effects, and whether the magnitude of this differs depending on the level of frailty, multimorbidity and kidney function within each trial.

We propose addressing these questions using two specific exemplars: 1. Novel antidiabetics for type 2 diabetes (see this protocol document for a description of the trials); 2. Cancer drugs for 4 common cancer sites: kidney/renal tract, colorectal, lung and melanoma. Where feasible (e.g. for the attrition risk prediction scores (the probability that an individual will experience trial attrition)) we will also validate the findings against the heterogeneous set of trials (21 index conditions across general medicine) which we have already extensively studied and for which we have considerable R code within the Vivli repository.
DOI: 10.5281/zenodo.8132659
title: miRNA read counts and mature sequences

description: Guppy post-filtered miRNA discovery set. Includes mature read counts, and sequences for three tissues.
DOI: 10.5281/zenodo.8132658
title: miRNA read counts and mature sequences

description: Guppy post-filtered miRNA discovery set. Includes mature read counts, and sequences for three tissues.
DOI: 10.5517/ccdc.csd.cc2dxwks
title: CCDC 2232296: Experimental Crystal Structure Determination

description: Related Article: Abdul K Choudhury, Bishnu Prasad Borah, Karishma Devi Borah, Jagannath Bhuyan|2023|J.Coord.Chem.|76|1|doi:10.1080/00958972.2023.2222876
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2fbnm2
title: CCDC 2244574: Experimental Crystal Structure Determination

description: Related Article: Kavuri Rupa, Dongari Yadagiri, Pazhamalai Anbarasan|2023|J.Org.Chem.|88|9077|doi:10.1021/acs.joc.3c00748
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2fbtwh
title: CCDC 2244737: Experimental Crystal Structure Determination

description: Related Article: Ekaterina E. Galenko, Mikhail S. Novikov, Alexander F. Khlebnikov|2023|J.Org.Chem.|88|8854|doi:10.1021/acs.joc.3c00654
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2fbtxj
title: CCDC 2244738: Experimental Crystal Structure Determination

description: Related Article: Ekaterina E. Galenko, Mikhail S. Novikov, Alexander F. Khlebnikov|2023|J.Org.Chem.|88|8854|doi:10.1021/acs.joc.3c00654
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.25318/9810035201-eng
title: Visible minority by gender and age: Census divisions

description: Data on visible minority by gender and age for the population in private households in census divisions.
DOI: 10.25318/9810035201-fra
title: Minorité visible selon le genre et l'âge : Divisions de recensement

description: Données sur les minorités visibles selon le genre et l'âge pour la population dans les ménages privés dans les divisions de recensement.
DOI: 10.6084/m9.figshare.23656782
title: Spirituality During Covid-19

description: The data from a survey about spiritual meaning and spiritual growth during Covid-19 lockdowns and quarantine.
DOI: 10.6084/m9.figshare.23656782.v1
title: Spirituality During Covid-19

description: The data from a survey about spiritual meaning and spiritual growth during Covid-19 lockdowns and quarantine.
DOI: 10.6084/m9.figshare.22532314.v1
title: Oh7B DRILs Dataset: Goss's wilt and MDR mapping

description: This is the data that accompanies the manuscript entitled "<strong>Identification of loci conferring resistance to four foliar diseases of maize</strong>". In this manuscript we collected data for Goss's wilt for three DRIL populations that are in an Oh7B background in 2018 and 2019. The files include the lines that were significant with the Dunnett's test (File S1), the markers that were significant from mapping (File S2) and the raw phenotypic data (File S3) and analysis file (File S4).
DOI: 10.5066/p9kkn921
title: Phytoplankton tally sheet, including photomicrographs, for samples collected at eleven large river sites throughout the United States, June through September 2017

description: This U.S. Geological Survey (USGS) Data Release provides the phytoplankton tally sheet, including photomicrographs, for samples collected from eleven large river sites throughout the United States, from June through September 2017. All data are raw tallies, not calculated abundances or concentrations. The dataset includes all routine and quality assurance/quality control samples collected as part of a National Water Quality Assessment Project pilot study to describe the potential for cyanobacteria and cyanotoxin ocurrence in the Nation's large rivers. Phytoplankton were identified to the lowest possible taxonomic level and abundances (density reported as natural units) are reported.