cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.13145/bacdive145708.20211221.6
title: Plesiomonas shigelloides

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.13145/bacdive145709.20211221.6
title: Plesiomonas shigelloides

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.13145/bacdive145710.20211221.6
title: Actinotignum schaalii

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.13145/bacdive145711.20211221.6
title: Rhodococcus erythropolis

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.13145/bacdive145712.20211221.6
title: Streptobacillus moniliformis

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.13145/bacdive145713.20211221.6
title: Streptococcus agalactiae

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.6084/m9.figshare.19740214
title: Raw Plaque-2.0 infection scores of the PCL screen for HSV, imaged and analysed at UZH.

description: virus indicates virus genotype, the PCL was tested against, compoundIdentifier indicates the UZH identifier for blinded testing by UZH, setPlate is the subset plate A to D and replicate refers to the replicate 1 to 3, wellRow and wellColumn indicate the well and plate indicate the screening plate sequence number. The Plaque2.0-based infection scores are numberOfNuclei reporting the number of nuclei based on Hoechst staining, numberOfInfectedNuclei refers to the number of GFP reporter-based number of infected nuclei, infectionIndex is the ratio of numberOfInfectedNuclei to numberOfNuclei, the number of GFP reporter-based plaques is given by numberOfPlaques and totalVirusIntensity indicates total GFP reporter signal intensity.
DOI: 10.6084/m9.figshare.19740214.v1
title: Raw Plaque-2.0 infection scores of the PCL screen for HSV, imaged and analysed at UZH.

description: virus indicates virus genotype, the PCL was tested against, compoundIdentifier indicates the UZH identifier for blinded testing by UZH, setPlate is the subset plate A to D and replicate refers to the replicate 1 to 3, wellRow and wellColumn indicate the well and plate indicate the screening plate sequence number. The Plaque2.0-based infection scores are numberOfNuclei reporting the number of nuclei based on Hoechst staining, numberOfInfectedNuclei refers to the number of GFP reporter-based number of infected nuclei, infectionIndex is the ratio of numberOfInfectedNuclei to numberOfNuclei, the number of GFP reporter-based plaques is given by numberOfPlaques and totalVirusIntensity indicates total GFP reporter signal intensity.
DOI: 10.6084/m9.figshare.19746607.v1
title: Processed Plaque-2.0 infection scores of the PCL screen for IAV, imaged and analysed at EPFL.

description: PCL compounds are indicated (name). The Plaque2.0-based infection scores of the four biological replicates of each PCL compound were averaged (mean). The Plaque2.0-based infection scores of the positive and negative controls are averaged (mean) over the 32 technical replicates, each, per plate. Each compound’s scores were normalized by the mean score of the negative control of the respective plate and indicated by Mean N_nuclei (number of nuclei based on Hoechst staining), Mean N_infected (number of GFP reporter-based infected nuclei), Mean InfIndex (ratio of numberOfInfectedNuclei to numberOfNuclei), Mean N_plaques (number of GFP reporter-based plaques) and Mean TotVirInt (total GFP reporter signal intensity). Non-toxic compounds were filtered by applying an inclusive μ- (mean of the negative control)  2σ (SD of the negative control) threshold for number of nuclei. Efficacy was filtered by applying an excluding μ-  2σ (SD of the negative control) threshold for the infection scores. The obtained scores for each infection score of each PCL compound indicated as Mean Scores N_nuclei (number of nuclei based on Hoechst staining), Scores N_Infected (number of GFP reporter-based number of infected nuclei), Scores InfIndex (ratio of numberOfInfectedNuclei to numberOfNuclei), Scores N_plaques (number of GFP reporter-based plaques) and Scores TotVirInt (total GFP reporter signal intensity). Compounds exhibiting significant toxicity to noninfected cells were excluded.
DOI: 10.13145/bacdive145714.20211221.6
title: Moraxella osloensis

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.6084/m9.figshare.19746610
title: Raw Plaque-2.0 infection scores of the PCL screen for IAV, imaged and analysed at EPFL.

description: Barcode indicates the screening plate sequence number defined by EPFL and Well Position gives the well. Plaque2.0-based infection scores are numberOfNuclei reporting the number of nuclei based on Hoechst stai¬ning, numberOfInfectedNuclei refers to the number of GFP reporter-based number of infected nu¬clei, infectionIndex is the ratio of numberOfInfectedNuclei to numberOfNuclei, the GFP reporter-based number of plaques is given by numberOfPlaques and totalVirusIntensity indicates total GFP reporter signal intensity.
DOI: 10.6084/m9.figshare.19746610.v1
title: Raw Plaque-2.0 infection scores of the PCL screen for IAV, imaged and analysed at EPFL.

description: Barcode indicates the screening plate sequence number defined by EPFL and Well Position gives the well. Plaque2.0-based infection scores are numberOfNuclei reporting the number of nuclei based on Hoechst stai¬ning, numberOfInfectedNuclei refers to the number of GFP reporter-based number of infected nu¬clei, infectionIndex is the ratio of numberOfInfectedNuclei to numberOfNuclei, the GFP reporter-based number of plaques is given by numberOfPlaques and totalVirusIntensity indicates total GFP reporter signal intensity.
DOI: 10.6084/m9.figshare.19746613
title: PCL compounds tested in the screening procedure of IAV.

description: PCL catalogue IDs (PCL_ID), compound names (CompoundName), PubChem identifier (CompoundPubChemCID) and link (CompoundPubChemURL), the tested concentration in µM (CompoundConcentrationMicroMolar), the CAS registry number (CAS), structure according SMILES notation (CompoundSMILES), acoustic dispensing spottability (SpottabilityFlag) and group (Group) for each of the 1,280 PCL compounds and control compounds.
DOI: 10.6084/m9.figshare.19746613.v1
title: PCL compounds tested in the screening procedure of IAV.

description: PCL catalogue IDs (PCL_ID), compound names (CompoundName), PubChem identifier (CompoundPubChemCID) and link (CompoundPubChemURL), the tested concentration in µM (CompoundConcentrationMicroMolar), the CAS registry number (CAS), structure according SMILES notation (CompoundSMILES), acoustic dispensing spottability (SpottabilityFlag) and group (Group) for each of the 1,280 PCL compounds and control compounds.
DOI: 10.6084/m9.figshare.19746616.v1
title: Processed Plaque-2.0 infection scores of the PCL screen for IAV, imaged and analysed at UZH.

description: virus indicates virus genotype, the PCL was tested against, compoundIdentifier indicates the UZH identifier for blinded testing by UZH, PCL_ID and compoundName disclose the PCL compound identifier and name, respectively. Barcode1, Barcode2, Barcode3 and Barcode4 indicate on which screening plates, given by the screening plate sequence number defined by EPFL, the PCL compound was tested on. The PrestoBlue toxicity scoring of the compound tested in noninfected cells is given as 1 (toxic) and 0 (non-toxic) in nonInfectedToxHit. The mean Plaque2.0-based infection scores of the four biological replicates are provided by mean_numberOfNuclei (number of nuclei based on Hoechst staining), mean_numberOfInfectedNuclei (number of GFP reporter-based infected nuclei), mean_infectionIndex (ratio of numberOfInfectedNuclei to numberOfNuclei), mean_numberOfPlaques (number of GFP reporter-based plaques) and mean_totalVirusIntensity (total GFP reporter signal intensity). The infection scores of the positive and negative controls are averaged (mean) over the 32 technical replicates, each, per plate, and the mean PCL compound infection scores were normalized by the mean negative control infection score of the respective plate indicated by by mean_numberOfNucleiRel (number of nuclei based on Hoechst staining), mean_numberOfInfectedNucleiRel (number of GFP reporter-based number of infected nuclei), mean_infectionIndexRel (ratio of numberOfInfectedNuclei to numberOfNuclei), mean_numberOfPlaquesRel (number of GFP reporter-based plaques) and mean_totalVirusIntensityRel (total GFP reporter signal intensity).
DOI: 10.13145/bacdive145715.20211221.6
title: Campylobacter coli

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.6084/m9.figshare.19746619.v1
title: Raw Plaque-2.0 infection scores of the PCL screen for IAV, imaged and analysed at UZH.

description: virus indicates virus genotype, the PCL was tested against, compoundIdentifier indicates the UZH identifier for blinded testing by UZH, setPlate is the subset plate A to D and replicate refers to the replicate 1 to 4, wellRow and wellColumn indicate the well and plate indicate the screening plate sequence number. The Plaque2.0-based infection scores are numberOfNuclei reporting the number of nuclei based on Hoechst staining, numberOfInfectedNuclei refers to the number of GFP reporter-based number of infected nuclei, infectionIndex is the ratio of numberOfInfectedNuclei to numberOfNuclei, the number of GFP reporter-based plaques is given by numberOfPlaques and totalVirusIntensity indicates total GFP reporter signal intensity.
DOI: 10.6084/m9.figshare.19746622
title: Raw Plaque-2.0 infection scores of the PCL screen for RV, imaged and analysed at EPFL.

description: Barcode indicates the screening plate sequence number defined by EPFL and Well Position gives the well. Plaque2.0-based infection scores are numberOfNuclei reporting the number of nuclei based on Hoechst stai¬ning, numberOfInfectedNuclei refers to the number of GFP reporter-based number of infected nu¬clei, infectionIndex is the ratio of numberOfInfectedNuclei to numberOfNuclei, the GFP reporter-based number of plaques is given by numberOfPlaques and totalVirusIntensity indicates total GFP reporter signal intensity.
DOI: 10.6084/m9.figshare.19746622.v1
title: Raw Plaque-2.0 infection scores of the PCL screen for RV, imaged and analysed at EPFL.

description: Barcode indicates the screening plate sequence number defined by EPFL and Well Position gives the well. Plaque2.0-based infection scores are numberOfNuclei reporting the number of nuclei based on Hoechst stai¬ning, numberOfInfectedNuclei refers to the number of GFP reporter-based number of infected nu¬clei, infectionIndex is the ratio of numberOfInfectedNuclei to numberOfNuclei, the GFP reporter-based number of plaques is given by numberOfPlaques and totalVirusIntensity indicates total GFP reporter signal intensity.
DOI: 10.6084/m9.figshare.19746625.v1
title: Raw Plaque-2.0 infection scores of the PCL screen for IAV, imaged and analysed at UZH.

description: virus indicates virus genotype, the PCL was tested against, compoundIdentifier indicates the UZH identifier for blinded testing by UZH, setPlate is the subset plate A to D and replicate refers to the replicate 1 to 4, wellRow and wellColumn indicate the well and plate indicate the screening plate sequence number. The Plaque2.0-based infection scores are numberOfNuclei reporting the number of nuclei based on Hoechst staining, numberOfInfectedNuclei refers to the number of GFP reporter-based number of infected nuclei, infectionIndex is the ratio of numberOfInfectedNuclei to numberOfNuclei, the number of GFP reporter-based plaques is given by numberOfPlaques and totalVirusIntensity indicates total GFP reporter signal intensity.
DOI: 10.6084/m9.figshare.19746628
title: Processed Plaque-2.0 infection scores of the PCL screen for RV, imaged and analysed at UZH.

description: virus indicates virus genotype, the PCL was tested against, compoundIdentifier indicates the UZH identifier for blinded testing by UZH, PCL_ID and compoundName disclose the PCL compound identifier and name, respectively. Barcode1, Barcode2, Barcode3 and Barcode4 indicate on which screening plates, given by the screening plate sequence number defined by EPFL, the PCL compound was tested on. The PrestoBlue toxicity scoring of the compound tested in noninfected cells is given as 1 (toxic) and 0 (non-toxic) in nonInfectedToxHit. The mean Plaque2.0-based infection scores of the four biological replicates are provided by mean_numberOfNuclei (number of nuclei based on Hoechst staining), mean_numberOfInfectedNuclei (number of GFP reporter-based infected nuclei), mean_infectionIndex (ratio of numberOfInfectedNuclei to numberOfNuclei), mean_numberOfPlaques (number of GFP reporter-based plaques) and mean_totalVirusIntensity (total GFP reporter signal intensity). The infection scores of the positive and negative controls are averaged (mean) over the 32 technical replicates, each, per plate, and the mean PCL compound infection scores were normalized by the mean negative control infection score of the respective plate indicated by by mean_numberOfNucleiRel (number of nuclei based on Hoechst staining), mean_numberOfInfectedNucleiRel (number of GFP reporter-based number of infected nuclei), mean_infectionIndexRel (ratio of numberOfInfectedNuclei to numberOfNuclei), mean_numberOfPlaquesRel (number of GFP reporter-based plaques) and mean_totalVirusIntensityRel (total GFP reporter signal intensity).
DOI: 10.6084/m9.figshare.19746628.v1
title: Processed Plaque-2.0 infection scores of the PCL screen for RV, imaged and analysed at UZH.

description: virus indicates virus genotype, the PCL was tested against, compoundIdentifier indicates the UZH identifier for blinded testing by UZH, PCL_ID and compoundName disclose the PCL compound identifier and name, respectively. Barcode1, Barcode2, Barcode3 and Barcode4 indicate on which screening plates, given by the screening plate sequence number defined by EPFL, the PCL compound was tested on. The PrestoBlue toxicity scoring of the compound tested in noninfected cells is given as 1 (toxic) and 0 (non-toxic) in nonInfectedToxHit. The mean Plaque2.0-based infection scores of the four biological replicates are provided by mean_numberOfNuclei (number of nuclei based on Hoechst staining), mean_numberOfInfectedNuclei (number of GFP reporter-based infected nuclei), mean_infectionIndex (ratio of numberOfInfectedNuclei to numberOfNuclei), mean_numberOfPlaques (number of GFP reporter-based plaques) and mean_totalVirusIntensity (total GFP reporter signal intensity). The infection scores of the positive and negative controls are averaged (mean) over the 32 technical replicates, each, per plate, and the mean PCL compound infection scores were normalized by the mean negative control infection score of the respective plate indicated by by mean_numberOfNucleiRel (number of nuclei based on Hoechst staining), mean_numberOfInfectedNucleiRel (number of GFP reporter-based number of infected nuclei), mean_infectionIndexRel (ratio of numberOfInfectedNuclei to numberOfNuclei), mean_numberOfPlaquesRel (number of GFP reporter-based plaques) and mean_totalVirusIntensityRel (total GFP reporter signal intensity).
DOI: 10.13145/bacdive145716.20211221.6
title: Campylobacter coli

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.6084/m9.figshare.19746607
title: Processed Plaque-2.0 infection scores of the PCL screen for IAV, imaged and analysed at EPFL.

description: PCL compounds are indicated (name). The Plaque2.0-based infection scores of the four biological replicates of each PCL compound were averaged (mean). The Plaque2.0-based infection scores of the positive and negative controls are averaged (mean) over the 32 technical replicates, each, per plate. Each compound’s scores were normalized by the mean score of the negative control of the respective plate and indicated by Mean N_nuclei (number of nuclei based on Hoechst staining), Mean N_infected (number of GFP reporter-based infected nuclei), Mean InfIndex (ratio of numberOfInfectedNuclei to numberOfNuclei), Mean N_plaques (number of GFP reporter-based plaques) and Mean TotVirInt (total GFP reporter signal intensity). Non-toxic compounds were filtered by applying an inclusive μ- (mean of the negative control)  2σ (SD of the negative control) threshold for number of nuclei. Efficacy was filtered by applying an excluding μ-  2σ (SD of the negative control) threshold for the infection scores. The obtained scores for each infection score of each PCL compound indicated as Mean Scores N_nuclei (number of nuclei based on Hoechst staining), Scores N_Infected (number of GFP reporter-based number of infected nuclei), Scores InfIndex (ratio of numberOfInfectedNuclei to numberOfNuclei), Scores N_plaques (number of GFP reporter-based plaques) and Scores TotVirInt (total GFP reporter signal intensity). Compounds exhibiting significant toxicity to noninfected cells were excluded.
DOI: 10.6084/m9.figshare.19746619
title: Raw Plaque-2.0 infection scores of the PCL screen for IAV, imaged and analysed at UZH.

description: virus indicates virus genotype, the PCL was tested against, compoundIdentifier indicates the UZH identifier for blinded testing by UZH, setPlate is the subset plate A to D and replicate refers to the replicate 1 to 4, wellRow and wellColumn indicate the well and plate indicate the screening plate sequence number. The Plaque2.0-based infection scores are numberOfNuclei reporting the number of nuclei based on Hoechst staining, numberOfInfectedNuclei refers to the number of GFP reporter-based number of infected nuclei, infectionIndex is the ratio of numberOfInfectedNuclei to numberOfNuclei, the number of GFP reporter-based plaques is given by numberOfPlaques and totalVirusIntensity indicates total GFP reporter signal intensity.
DOI: 10.6084/m9.figshare.19746631
title: PCL compounds excluded due to toxicity in uninfected cells for the IAV screen.

description: The toxicity of the PCL compounds in absence of infection was evaluated by PrestoBlue viability assay. Compounds are indicated by their PCL catalogue ID (PCL_ID) and names (compoundName). Compounds were classified as toxic, when their normalized value for all replicates was higher than the average +3σ of the DMSO negative control for the corresponding plate. Scores and score standard deviation (scoreSD) of toxic PCL compounds are listed. The PrestoBlue raw data are available at idr0081/3-Screen/Analysis/Toxicity.xls.
DOI: 10.6084/m9.figshare.19746631.v1
title: PCL compounds excluded due to toxicity in uninfected cells for the IAV screen.

description: The toxicity of the PCL compounds in absence of infection was evaluated by PrestoBlue viability assay. Compounds are indicated by their PCL catalogue ID (PCL_ID) and names (compoundName). Compounds were classified as toxic, when their normalized value for all replicates was higher than the average +3σ of the DMSO negative control for the corresponding plate. Scores and score standard deviation (scoreSD) of toxic PCL compounds are listed. The PrestoBlue raw data are available at idr0081/3-Screen/Analysis/Toxicity.xls.
DOI: 10.6084/m9.figshare.19746634
title: Processed Plaque-2.0 infection scores of the PCL screen for RV, imaged and analysed at EPFL

description: PCL compounds are indicated (name). The Plaque2.0-based infection scores of the four biological replicates of each PCL compound were averaged (mean). The Plaque2.0-based infection scores of the positive and negative controls are averaged (mean) over the 32 technical replicates, each, per plate. Each compound’s scores were normalized by the mean score of the negative control of the respective plate and indicated by Mean N_nuclei (number of nuclei based on Hoechst staining), Mean N_infected (number of GFP reporter-based infected nuclei), Mean InfIndex (ratio of numberOfInfectedNuclei to numberOfNuclei), Mean N_plaques (number of GFP reporter-based plaques) and Mean TotVirInt (total GFP reporter signal intensity). Non-toxic compounds were filtered by applying an inclusive μ- (mean of the negative control)  2σ (SD of the negative control) threshold for number of nuclei. Efficacy was filtered by applying an excluding μ-  2σ (SD of the negative control) threshold for the infection scores. The obtained scores for each infection score of each PCL compound indicated as Mean Scores N_nuclei (number of nuclei based on Hoechst staining), Scores N_Infected (number of GFP reporter-based number of infected nuclei), Scores InfIndex (ratio of numberOfInfectedNuclei to numberOfNuclei), Scores N_plaques (number of GFP reporter-based plaques) and Scores TotVirInt (total GFP reporter signal intensity). Compounds exhibiting significant toxicity to noninfected cells were excluded.
DOI: 10.6084/m9.figshare.19746634.v1
title: Processed Plaque-2.0 infection scores of the PCL screen for RV, imaged and analysed at EPFL

description: PCL compounds are indicated (name). The Plaque2.0-based infection scores of the four biological replicates of each PCL compound were averaged (mean). The Plaque2.0-based infection scores of the positive and negative controls are averaged (mean) over the 32 technical replicates, each, per plate. Each compound’s scores were normalized by the mean score of the negative control of the respective plate and indicated by Mean N_nuclei (number of nuclei based on Hoechst staining), Mean N_infected (number of GFP reporter-based infected nuclei), Mean InfIndex (ratio of numberOfInfectedNuclei to numberOfNuclei), Mean N_plaques (number of GFP reporter-based plaques) and Mean TotVirInt (total GFP reporter signal intensity). Non-toxic compounds were filtered by applying an inclusive μ- (mean of the negative control)  2σ (SD of the negative control) threshold for number of nuclei. Efficacy was filtered by applying an excluding μ-  2σ (SD of the negative control) threshold for the infection scores. The obtained scores for each infection score of each PCL compound indicated as Mean Scores N_nuclei (number of nuclei based on Hoechst staining), Scores N_Infected (number of GFP reporter-based number of infected nuclei), Scores InfIndex (ratio of numberOfInfectedNuclei to numberOfNuclei), Scores N_plaques (number of GFP reporter-based plaques) and Scores TotVirInt (total GFP reporter signal intensity). Compounds exhibiting significant toxicity to noninfected cells were excluded.
DOI: 10.6084/m9.figshare.19746640
title: PCL compounds excluded due to toxicity in uninfected cells for the RV screen.

description: The toxicity of the PCL compounds in absence of infection was evaluated by PrestoBlue viability assay. Compounds are indicated by their PCL catalogue ID (PCL_ID) and names (compoundName). Compounds were classified as toxic, when their normalized value for all replicates was higher than the average +3σ of the DMSO negative control for the corresponding plate. Scores and score standard deviation (scoreSD) of toxic PCL compounds are listed. The PrestoBlue raw data are available at idr0081/3-Screen/Analysis/Toxicity.xls.
DOI: 10.13145/bacdive145717.20211221.6
title: Campylobacter lari

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.