cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.11931300
title: Profiling variability and development of spoken discourse in mainstream adolescents

description: Competence in spoken discourse is an important consideration during assessment and intervention planning for adolescents with communication difficulties. Currently, a lack of age-appropriate protocols and reference data against which to interpret performance, are barriers when working with this population, particularly those that assess a range of genre and language features. Using a new assessment tool, the Curtin University Discourse Protocol-Adolescent (CUDP-A), this study aimed to collect and describe spoken discourse samples from a large group of adolescents (n = 160), aged 12 to 15 years, recruited to represent a mainstream academic cohort. For each participant, samples of recount (<i>n = </i>3), expository (<i>n = </i>3), persuasive (<i>n = </i>3), and narrative (<i>n = </i>2) discourse were described using theoretically supported measurements sensitive to micro-linguistic, micro-structural, macro-structural, and super-structural discourse features. Participants also completed a standardized assessment of oral language. Variability was found in micro-linguistic and micro-structural features, with stability seen in macro-structural and super-structural features. Few age- and gender-related differences were observed, while multiple significant correlations between spoken discourse and oral language variables were revealed across the sample. The CUDP-A was successful in eliciting spoken discourse across genres relevant to social and academic contexts, enabling an in-depth description of adolescent discourse. This tool, supported by the reference data, provides a new opportunity to assess spoken discourse skills in adolescents from clinical populations, e.g., acquired brain injury or developmental disorders. Further research is needed to examine factors influencing discourse ability, such as those that may be related to genre, or contextual factors related to the presence of communication partners, with novel tools such as the CUDP-A facilitating this.
DOI: 10.6084/m9.figshare.11931300.v1
title: Profiling variability and development of spoken discourse in mainstream adolescents

description: Competence in spoken discourse is an important consideration during assessment and intervention planning for adolescents with communication difficulties. Currently, a lack of age-appropriate protocols and reference data against which to interpret performance, are barriers when working with this population, particularly those that assess a range of genre and language features. Using a new assessment tool, the Curtin University Discourse Protocol-Adolescent (CUDP-A), this study aimed to collect and describe spoken discourse samples from a large group of adolescents (n = 160), aged 12 to 15 years, recruited to represent a mainstream academic cohort. For each participant, samples of recount (<i>n = </i>3), expository (<i>n = </i>3), persuasive (<i>n = </i>3), and narrative (<i>n = </i>2) discourse were described using theoretically supported measurements sensitive to micro-linguistic, micro-structural, macro-structural, and super-structural discourse features. Participants also completed a standardized assessment of oral language. Variability was found in micro-linguistic and micro-structural features, with stability seen in macro-structural and super-structural features. Few age- and gender-related differences were observed, while multiple significant correlations between spoken discourse and oral language variables were revealed across the sample. The CUDP-A was successful in eliciting spoken discourse across genres relevant to social and academic contexts, enabling an in-depth description of adolescent discourse. This tool, supported by the reference data, provides a new opportunity to assess spoken discourse skills in adolescents from clinical populations, e.g., acquired brain injury or developmental disorders. Further research is needed to examine factors influencing discourse ability, such as those that may be related to genre, or contextual factors related to the presence of communication partners, with novel tools such as the CUDP-A facilitating this.
DOI: 10.6084/m9.figshare.12850085
title: Online survey of genital and urinary symptoms among Japanese women aged between 40 and 90 years

description: The purpose of this survey was to assess the prevalence of genital and urinary tract symptoms among Japanese women with declining estrogen levels. A health-related questionnaire survey was conducted among women in their 40s or older to inquire about their genital, intercourse-related, and urinary symptoms and concern over their symptoms. Of the consecutive 10,000 respondents recruited, 4488 (44.9%) reported having symptoms: 3546 (79.0%) expressed concern over their symptoms. Furthermore, 2173 women (21.7%) had incontinence, 1999 (20.0%) had urinary frequency, 1648 (16.5%) had itching, and 1560 (15.6%) reported odor; these were followed by looseness, dryness, and burning. Of the 2518 (25.2%) sexually active women, 518 (20.6%) reported having dyspareunia and more reported having urinary symptoms than genital symptoms. Of the symptomatic respondents, 33.1% had genital symptoms alone, 28.4% had urinary symptoms alone, and 38.4% had both. More sexually active women had genital symptoms, while more sexually inactive women had urinary symptoms. Genital and urinary symptoms were shown to be common and coexist in a considerable proportion of the respondents, highlighting the pathology of genitourinary syndrome of menopause. Again, dyspareunia and lower urinary tract symptoms were shown to be quite common among postmenopausal women.
DOI: 10.6084/m9.figshare.12850085.v1
title: Online survey of genital and urinary symptoms among Japanese women aged between 40 and 90 years

description: The purpose of this survey was to assess the prevalence of genital and urinary tract symptoms among Japanese women with declining estrogen levels. A health-related questionnaire survey was conducted among women in their 40s or older to inquire about their genital, intercourse-related, and urinary symptoms and concern over their symptoms. Of the consecutive 10,000 respondents recruited, 4488 (44.9%) reported having symptoms: 3546 (79.0%) expressed concern over their symptoms. Furthermore, 2173 women (21.7%) had incontinence, 1999 (20.0%) had urinary frequency, 1648 (16.5%) had itching, and 1560 (15.6%) reported odor; these were followed by looseness, dryness, and burning. Of the 2518 (25.2%) sexually active women, 518 (20.6%) reported having dyspareunia and more reported having urinary symptoms than genital symptoms. Of the symptomatic respondents, 33.1% had genital symptoms alone, 28.4% had urinary symptoms alone, and 38.4% had both. More sexually active women had genital symptoms, while more sexually inactive women had urinary symptoms. Genital and urinary symptoms were shown to be common and coexist in a considerable proportion of the respondents, highlighting the pathology of genitourinary syndrome of menopause. Again, dyspareunia and lower urinary tract symptoms were shown to be quite common among postmenopausal women.
DOI: 10.6084/m9.figshare.13055737.v2
title: Review & meta-analysis: isopropanolic black cohosh extract iCR for menopausal symptoms – an update on the evidence

description: A systematic literature search revealed 35 clinical studies and one meta-analysis comprising 43,759 women, of which 13,096 were treated with isopropanolic <i>Cimicifuga racemosa</i> extract (iCR). Compared to placebo, iCR was significantly superior for treating neurovegetative and psychological menopausal symptoms, with a standardized mean difference of −0.694 in favor of iCR (<i>p</i> Hypericum perforatum [HP]) were given (−1.020 and −0.999, respectively), suggesting a dose-dependency. For psychological symptoms, the iCR+HP combination was superior to iCR monotherapy. Efficacy of iCR was comparable to low-dose transdermal estradiol or tibolone. Yet, due to its better tolerability, iCR had a significantly better benefit–risk profile than tibolone. Treatment with iCR/iCR+HP was well tolerated with few minor adverse events, with a frequency comparable to placebo. The clinical data did not reveal any evidence of hepatotoxicity. Hormone levels remained unchanged and estrogen-sensitive tissues (e.g. breast, endometrium) were unaffected by iCR treatment. As benefits clearly outweigh risks, iCR/iCR+HP should be recommended as an evidence-based treatment option for natural climacteric symptoms. With its good safety profile in general and at estrogen-sensitive organs, iCR as a non-hormonal herbal therapy can also be used in patients with hormone-dependent diseases who suffer from iatrogenic climacteric symptoms.
DOI: 10.6084/m9.figshare.13055737
title: Review & meta-analysis: isopropanolic black cohosh extract iCR for menopausal symptoms – an update on the evidence

description: A systematic literature search revealed 35 clinical studies and one meta-analysis comprising 43,759 women, of which 13,096 were treated with isopropanolic <i>Cimicifuga racemosa</i> extract (iCR). Compared to placebo, iCR was significantly superior for treating neurovegetative and psychological menopausal symptoms, with a standardized mean difference of −0.694 in favor of iCR (<i>p</i> Hypericum perforatum [HP]) were given (−1.020 and −0.999, respectively), suggesting a dose-dependency. For psychological symptoms, the iCR+HP combination was superior to iCR monotherapy. Efficacy of iCR was comparable to low-dose transdermal estradiol or tibolone. Yet, due to its better tolerability, iCR had a significantly better benefit–risk profile than tibolone. Treatment with iCR/iCR+HP was well tolerated with few minor adverse events, with a frequency comparable to placebo. The clinical data did not reveal any evidence of hepatotoxicity. Hormone levels remained unchanged and estrogen-sensitive tissues (e.g. breast, endometrium) were unaffected by iCR treatment. As benefits clearly outweigh risks, iCR/iCR+HP should be recommended as an evidence-based treatment option for natural climacteric symptoms. With its good safety profile in general and at estrogen-sensitive organs, iCR as a non-hormonal herbal therapy can also be used in patients with hormone-dependent diseases who suffer from iatrogenic climacteric symptoms.
DOI: 10.6084/m9.figshare.13154577
title: Dietary intake and menopausal symptoms in postmenopausal women: a systematic review

description: Despite literature pointing to a relation between dietary intake and menopausal symptoms, most studies have evaluated either only supplements or only specific nutrients or foods. Therefore, this study aimed to provide a systematic review of the literature regarding the association between dietary intake and menopausal symptoms in postmenopausal women. A systematic search was conducted across PubMed/Medline, Web of Science, Scopus, and Embase to identify studies published between 2009 and 2019. We identified 3828 studies; after screening, 73 studies were reviewed and 19 of these investigated nutrient and food intake and eating patterns associated with the intensity of menopausal symptoms. Studies evaluating diet quality or dietary patterns showed an association between lower intensity of psychological symptoms, sleep disorders, and vasomotor, urogenital, and somatic symptoms and higher consumption of vegetables, whole grains, and unprocessed foods. Also, the intensity of these symptoms is associated with high-processed foods, saturated fats, and sugars. Regarding nutrient and/or specific food, the studies indicated an association between caffeine intake and type of fat intake and the intensity of menopausal symptoms. Dietary intake was found to be associated with the severity of menopausal symptoms; however, evidence for the association between dietary intake and menopausal symptoms is inconsistent and inconclusive, and is provided by a small number of studies.
DOI: 10.6084/m9.figshare.13154577.v1
title: Dietary intake and menopausal symptoms in postmenopausal women: a systematic review

description: Despite literature pointing to a relation between dietary intake and menopausal symptoms, most studies have evaluated either only supplements or only specific nutrients or foods. Therefore, this study aimed to provide a systematic review of the literature regarding the association between dietary intake and menopausal symptoms in postmenopausal women. A systematic search was conducted across PubMed/Medline, Web of Science, Scopus, and Embase to identify studies published between 2009 and 2019. We identified 3828 studies; after screening, 73 studies were reviewed and 19 of these investigated nutrient and food intake and eating patterns associated with the intensity of menopausal symptoms. Studies evaluating diet quality or dietary patterns showed an association between lower intensity of psychological symptoms, sleep disorders, and vasomotor, urogenital, and somatic symptoms and higher consumption of vegetables, whole grains, and unprocessed foods. Also, the intensity of these symptoms is associated with high-processed foods, saturated fats, and sugars. Regarding nutrient and/or specific food, the studies indicated an association between caffeine intake and type of fat intake and the intensity of menopausal symptoms. Dietary intake was found to be associated with the severity of menopausal symptoms; however, evidence for the association between dietary intake and menopausal symptoms is inconsistent and inconclusive, and is provided by a small number of studies.
DOI: 10.6084/m9.figshare.13055737.v1
title: Review & meta-analysis: isopropanolic black cohosh extract iCR for menopausal symptoms – an update on the evidence

description: A systematic literature search revealed 35 clinical studies and one meta-analysis comprising 43,759 women, of which 13,096 were treated with isopropanolic <i>Cimicifuga racemosa</i> extract (iCR). Compared to placebo, iCR was significantly superior for treating neurovegetative and psychological menopausal symptoms, with a standardized mean difference of −0.694 in favor of iCR (<i>p</i> Hypericum perforatum [HP]) were given (−1.020 and −0.999, respectively), suggesting a dose-dependency. For psychological symptoms, the iCR+HP combination was superior to iCR monotherapy. Efficacy of iCR was comparable to low-dose transdermal estradiol or tibolone. Yet, due to its better tolerability, iCR had a significantly better benefit–risk profile than tibolone. Treatment with iCR/iCR+HP was well tolerated with few minor adverse events, with a frequency comparable to placebo. The clinical data did not reveal any evidence of hepatotoxicity. Hormone levels remained unchanged and estrogen-sensitive tissues (e.g. breast, endometrium) were unaffected by iCR treatment. As benefits clearly outweigh risks, iCR/iCR+HP should be recommended as an evidence-based treatment option for natural climacteric symptoms. With its good safety profile in general and at estrogen-sensitive organs, iCR as a non-hormonal herbal therapy can also be used in patients with hormone-dependent diseases who suffer from iatrogenic climacteric symptoms.
DOI: 10.6084/m9.figshare.12887113
title: Language impairment with a microduplication in 1q42.3q43

description: Deletions and duplications of the distal region of the long arm of chromosome 1 are associated with brain abnormalities and developmental delay. Because duplications are less frequent than deletions, no detailed account of the cognitive profile of the affected people is available, particularly, regarding their language (dis)abilities. In this paper we report on the cognitive and language capacities of a girl with one of the smallest interstitial duplications ever described in this region, affecting to 1q42.3q43 (arr[hg19] 1q42.3q43(235,963,632–236,972,276)x3), and advance potential candidate genes for the observed deficits. The proband’s speech is severely impaired, exhibiting dysarthric-like features, with speech problems also resulting from a phonological deficit boiling down to a verbal auditory memory deficit. Lexical and grammatical knowledge are also impaired, impacting negatively on both expressive and receptive abilities, seemingly as a consequence of the phonological deficit. Still, her pragmatic abilities seem to be significantly spared, granting her a good command on the principles governing conversational exchanges. Genetic analyses point to several genes of interest. These include one gene within the duplicated region (<i>LYST</i>), one predicted functional partner (<i>CMIP</i>), and three genes outside the 1q42.3q43 region, which are all highly expressed in the cerebellum: <i>DDIT4</i> and <i>SLC29A1</i>, found strongly downregulated in the proband compared to her healthy parents, and <i>CNTNAP3</i>, found strongly upregulated. The genes highlighted in the paper emerge as potential candidates for the phonological and speech deficits exhibited by the proband and ultimately, for her problems with language.
DOI: 10.6084/m9.figshare.12887113.v1
title: Language impairment with a microduplication in 1q42.3q43

description: Deletions and duplications of the distal region of the long arm of chromosome 1 are associated with brain abnormalities and developmental delay. Because duplications are less frequent than deletions, no detailed account of the cognitive profile of the affected people is available, particularly, regarding their language (dis)abilities. In this paper we report on the cognitive and language capacities of a girl with one of the smallest interstitial duplications ever described in this region, affecting to 1q42.3q43 (arr[hg19] 1q42.3q43(235,963,632–236,972,276)x3), and advance potential candidate genes for the observed deficits. The proband’s speech is severely impaired, exhibiting dysarthric-like features, with speech problems also resulting from a phonological deficit boiling down to a verbal auditory memory deficit. Lexical and grammatical knowledge are also impaired, impacting negatively on both expressive and receptive abilities, seemingly as a consequence of the phonological deficit. Still, her pragmatic abilities seem to be significantly spared, granting her a good command on the principles governing conversational exchanges. Genetic analyses point to several genes of interest. These include one gene within the duplicated region (<i>LYST</i>), one predicted functional partner (<i>CMIP</i>), and three genes outside the 1q42.3q43 region, which are all highly expressed in the cerebellum: <i>DDIT4</i> and <i>SLC29A1</i>, found strongly downregulated in the proband compared to her healthy parents, and <i>CNTNAP3</i>, found strongly upregulated. The genes highlighted in the paper emerge as potential candidates for the phonological and speech deficits exhibited by the proband and ultimately, for her problems with language.
DOI: 10.17632/n6xcy45p45.1
title: Data for: Longitudinal Prediction of Children's Math Anxiety from Parent-Child Relationship

description: Research Data concludes three separated files: 1. Common method bias 2. Equivalence analysis 3. Cross-lagged models of parent-child relationship and math anxiety
DOI: 10.17632/njxbvwt6fz.1
title: Data for: A Study on Steam Cycle Optimization for Integrating Energy Storage System to Nuclear Power Plant

description: Raw result data in forms of MATLAB files
DOI: 10.17632/p232p68bgk.1
title: Data for: Think and Pair before Share: Effects of Collaboration on Students' Oral Participation

description: It is the long format of all the relevant variables rereported in the study.
DOI: 10.17632/mzbshs9x8b.1
title: Data for: TClustVID: A Novel Machine Learning Classification Model to Investigate Topics and Sentiment in COVID-19 Tweets

description: It is generated as supplementary data in this work
DOI: 10.6084/m9.figshare.13312889
title: Identification of Two Subgroups of FOLFOX Resistance Patterns and Prediction of FOLFOX Response in Colorectal Cancer Patients

description: To dissect gene expression subgroups of FOLFOX resistance colorectal cancer(CRC) and predict FOLFOX response, gene expression data of 83 stage IV CRC tumor samples (FOLFOX responder <i>n</i> = 42, non-responder <i>n</i> = 41) are used to develop a novel iterative supervised learning method IML. IML identified two mutually exclusive subgroups of CRC patients that rely on different DNA damage repair proteins and resist FOLFOX. IML was validated in two validation sets (HR = 2.6, <i>p</i> Value = 0.02; HR = 2.36, <i>p</i> value = 0.02). A subgroup of mesenchymal subtype patients benefit from FOLFOX. Different subgroups of FOLFOX nonresponders may need to be treated differently.
DOI: 10.6084/m9.figshare.13312889.v1
title: Identification of Two Subgroups of FOLFOX Resistance Patterns and Prediction of FOLFOX Response in Colorectal Cancer Patients

description: To dissect gene expression subgroups of FOLFOX resistance colorectal cancer(CRC) and predict FOLFOX response, gene expression data of 83 stage IV CRC tumor samples (FOLFOX responder <i>n</i> = 42, non-responder <i>n</i> = 41) are used to develop a novel iterative supervised learning method IML. IML identified two mutually exclusive subgroups of CRC patients that rely on different DNA damage repair proteins and resist FOLFOX. IML was validated in two validation sets (HR = 2.6, <i>p</i> Value = 0.02; HR = 2.36, <i>p</i> value = 0.02). A subgroup of mesenchymal subtype patients benefit from FOLFOX. Different subgroups of FOLFOX nonresponders may need to be treated differently.
DOI: 10.6084/m9.figshare.13554615.v1
title: Dynamic Changes of Mitochondrial DNA Copy Number in Gastrointestinal Tract Cancers: A Systematic Review and Meta-Analysis

description: We have performed a systematic review and meta-analysis for evaluation of mitochondrial DNA copy number (mtDNA-CN) alterations in peripheral blood leukocytes (PBL), and tumor tissues of gastrointestinal tract (GIT) cancers. Analysis of the PBL demonstrated a significant decrease [OR: 0.6 (0.5, 0.8)] and increase [OR: 1.4 (1.1, 1.9)] prior to and following GIT cancer development, respectively. This trend was more evident in CRC, and GC subgroups. Analysis of tissue yielded high levels of heterogeneity. However, the mean difference for the CRC subgroup was statistically significant [1.5 (1.0, 2.2)]. Our analysis suggests mtDNA-CN deserves further investigations as a GIT-cancer screening tool.
DOI: 10.6084/m9.figshare.13554615
title: Dynamic Changes of Mitochondrial DNA Copy Number in Gastrointestinal Tract Cancers: A Systematic Review and Meta-Analysis

description: We have performed a systematic review and meta-analysis for evaluation of mitochondrial DNA copy number (mtDNA-CN) alterations in peripheral blood leukocytes (PBL), and tumor tissues of gastrointestinal tract (GIT) cancers. Analysis of the PBL demonstrated a significant decrease [OR: 0.6 (0.5, 0.8)] and increase [OR: 1.4 (1.1, 1.9)] prior to and following GIT cancer development, respectively. This trend was more evident in CRC, and GC subgroups. Analysis of tissue yielded high levels of heterogeneity. However, the mean difference for the CRC subgroup was statistically significant [1.5 (1.0, 2.2)]. Our analysis suggests mtDNA-CN deserves further investigations as a GIT-cancer screening tool.