cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.12057408
title: Additional file 2 of A comprehensive analysis of sialolith proteins and the clinical implications

description: Additional file 2. Raw mass spectrometry data output.
DOI: 10.6084/m9.figshare.12057408.v1
title: Additional file 2 of A comprehensive analysis of sialolith proteins and the clinical implications

description: Additional file 2. Raw mass spectrometry data output.
DOI: 10.6084/m9.figshare.12057378
title: Additional file 5 of What evidence exists for the impact of Baltic Sea ecosystems on human health and well-being? A systematic map protocol

description: Additional file 5. Coding strategy.
DOI: 10.6084/m9.figshare.12057369
title: Additional file 8 of Comprehensive mapping of the cell response to E. coli infection in porcine intestinal epithelial cells pretreated with exopolysaccharide derived from Lactobacillus reuteri

description: Additional file 8. Genes identified through RNA-seq in the downstream bioinformatics analysis. Data sets from 1.1 to 1.3—Differentially expressed genes (DEGs) found in the cells subjected to one of the three treatments. Data sets from 1.4 to 1.7—Common genes identified among the treated cells. Data sets from 1.8 to 1.10—Molecular pathways identified in the treated cells.
DOI: 10.6084/m9.figshare.12057369.v1
title: Additional file 8 of Comprehensive mapping of the cell response to E. coli infection in porcine intestinal epithelial cells pretreated with exopolysaccharide derived from Lactobacillus reuteri

description: Additional file 8. Genes identified through RNA-seq in the downstream bioinformatics analysis. Data sets from 1.1 to 1.3—Differentially expressed genes (DEGs) found in the cells subjected to one of the three treatments. Data sets from 1.4 to 1.7—Common genes identified among the treated cells. Data sets from 1.8 to 1.10—Molecular pathways identified in the treated cells.
DOI: 10.6084/m9.figshare.12057378.v1
title: Additional file 5 of What evidence exists for the impact of Baltic Sea ecosystems on human health and well-being? A systematic map protocol

description: Additional file 5. Coding strategy.
DOI: 10.6084/m9.figshare.12057363
title: Additional file 3 of What evidence exists for the impact of Baltic Sea ecosystems on human health and well-being? A systematic map protocol

description: Additional file 3. Risks and benefits related to MSFD.
DOI: 10.6084/m9.figshare.12057363.v1
title: Additional file 3 of What evidence exists for the impact of Baltic Sea ecosystems on human health and well-being? A systematic map protocol

description: Additional file 3. Risks and benefits related to MSFD.
DOI: 10.6084/m9.figshare.12057348
title: Additional file 1 of What evidence exists for the impact of Baltic Sea ecosystems on human health and well-being? A systematic map protocol

description: Additional file 1. ROSES form.
DOI: 10.6084/m9.figshare.12057348.v1
title: Additional file 1 of What evidence exists for the impact of Baltic Sea ecosystems on human health and well-being? A systematic map protocol

description: Additional file 1. ROSES form.
DOI: 10.6084/m9.figshare.12057234
title: Additional file 1 of Successful generation of epigenetic disease model mice by targeted demethylation of the epigenome

description: Generation of EpiEdit mice derived from ESCs via tetraploid complementation. Table S2. Generation of EpiEdit mice by transient expression of epigenome editing factors. Table S3. Generation of EpiEdit mice by stable expression of epigenome editing factors. Table S4. gRNAs and primers for mouse experiment. Table S5. gRNAs and primers for human experiment.
DOI: 10.6084/m9.figshare.12057234.v1
title: Additional file 1 of Successful generation of epigenetic disease model mice by targeted demethylation of the epigenome

description: Generation of EpiEdit mice derived from ESCs via tetraploid complementation. Table S2. Generation of EpiEdit mice by transient expression of epigenome editing factors. Table S3. Generation of EpiEdit mice by stable expression of epigenome editing factors. Table S4. gRNAs and primers for mouse experiment. Table S5. gRNAs and primers for human experiment.
DOI: 10.6084/m9.figshare.12057213
title: Additional file 4 of CRISPRi-based radiation modifier screen identifies long non-coding RNA therapeutic targets in glioma

description: Additional file 4: Table S3. DESeq2 output of differentially expressed genes following ASO knockdown of lncGRS-1 compared to negative control ASO in GBM U87, DIPG SF8628, and NHA cells.
DOI: 10.6084/m9.figshare.12057210
title: Additional file 3 of CRISPRi-based radiation modifier screen identifies long non-coding RNA therapeutic targets in glioma

description: Additional file 3: Table S2. CRISPRi sgRNA protospacer sequences used for individual knockdown, qPCR primers used, and ASO targeting sequences.
DOI: 10.6084/m9.figshare.12057210.v1
title: Additional file 3 of CRISPRi-based radiation modifier screen identifies long non-coding RNA therapeutic targets in glioma

description: Additional file 3: Table S2. CRISPRi sgRNA protospacer sequences used for individual knockdown, qPCR primers used, and ASO targeting sequences.
DOI: 10.6084/m9.figshare.12057207
title: Additional file 2 of CRISPRi-based radiation modifier screen identifies long non-coding RNA therapeutic targets in glioma

description: Additional file 2: Table S1. CRISPRi radiation screen results using sgRNAs from the CRISPRi Non-Coding Library.
DOI: 10.6084/m9.figshare.12057213.v1
title: Additional file 4 of CRISPRi-based radiation modifier screen identifies long non-coding RNA therapeutic targets in glioma

description: Additional file 4: Table S3. DESeq2 output of differentially expressed genes following ASO knockdown of lncGRS-1 compared to negative control ASO in GBM U87, DIPG SF8628, and NHA cells.
DOI: 10.6084/m9.figshare.12057207.v1
title: Additional file 2 of CRISPRi-based radiation modifier screen identifies long non-coding RNA therapeutic targets in glioma

description: Additional file 2: Table S1. CRISPRi radiation screen results using sgRNAs from the CRISPRi Non-Coding Library.
DOI: 10.6084/m9.figshare.12057135
title: Counts of G.secunda and O.cysticum from Measuring aggregation in parasite populations

description: Counts of G.secunda and O.cysticum in host (Scomberomorus commerson) from several locations in eastern Australia.
DOI: 10.6084/m9.figshare.12057135.v1
title: Counts of G.secunda and O.cysticum from Measuring aggregation in parasite populations

description: Counts of G.secunda and O.cysticum in host (Scomberomorus commerson) from several locations in eastern Australia.
DOI: 10.6084/m9.figshare.12057126
title: Table S1 from Development and testing of a novel killer–rescue self-limiting gene drive system in <i>Drosophila melanogaster</i>

description: Here we report the development and testing of a novel self-limiting gene drive system, Killer–Rescue (K–R), in <i>Drosophila melanogaster</i>. This system is composed of an autoregulated Gal4 Killer (K) and a Gal4-activated Gal80 Rescue (R). Overexpression of Gal4 is lethal, but in the presence of R activation of Gal80 leads to much lower levels of Gal4 and R of lethality. We demonstrate that with a single 2 : 1 engineered to wild-type release, K drives R through the population and after nine generations, more than 98% of the population carry R and less than 2% of the population are wild-type flies. We discuss how this simple K–R gene drive system may be readily adapted for population replacement in a human health pest, <i>Aedes aegypti</i>, or for population suppression in an agricultural pest, <i>Drosophila suzukii</i>.
DOI: 10.6084/m9.figshare.12057126.v1
title: Table S1 from Development and testing of a novel killer–rescue self-limiting gene drive system in <i>Drosophila melanogaster</i>

description: Here we report the development and testing of a novel self-limiting gene drive system, Killer–Rescue (K–R), in <i>Drosophila melanogaster</i>. This system is composed of an autoregulated Gal4 Killer (K) and a Gal4-activated Gal80 Rescue (R). Overexpression of Gal4 is lethal, but in the presence of R activation of Gal80 leads to much lower levels of Gal4 and R of lethality. We demonstrate that with a single 2 : 1 engineered to wild-type release, K drives R through the population and after nine generations, more than 98% of the population carry R and less than 2% of the population are wild-type flies. We discuss how this simple K–R gene drive system may be readily adapted for population replacement in a human health pest, <i>Aedes aegypti</i>, or for population suppression in an agricultural pest, <i>Drosophila suzukii</i>.
DOI: 10.6084/m9.figshare.12057114
title: Appendix 3 from The smallest known Devonian tetrapod shows unexpectedly derived features

description: Phylogenetic matrix in NEXUS format
DOI: 10.6084/m9.figshare.12057114.v1
title: Appendix 3 from The smallest known Devonian tetrapod shows unexpectedly derived features

description: Phylogenetic matrix in NEXUS format
DOI: 10.6084/m9.figshare.12057108
title: Source code from Vibrations of nonlinear elastic lattices: low- and high-frequency dynamic models, internal resonances and modes coupling

description: The source code for CAS wxMaxima
DOI: 10.6084/m9.figshare.12057093
title: Supplementary Data from Greater variability in chimpanzee (<i>Pan troglodytes</i>) brain structure among males

description: Data used in the analyses presented
DOI: 10.6084/m9.figshare.12057093.v1
title: Supplementary Data from Greater variability in chimpanzee (<i>Pan troglodytes</i>) brain structure among males

description: Data used in the analyses presented
DOI: 10.6084/m9.figshare.12057075
title: Ipsi EGFP - ipsi eye stim raw branch lengths

description: Xenopus RGC axon branch dynamics <br>Data generated by Dynamo reconstructions of RGC axons imaged in the optic tectum in darkness and with visual stimulation. These datasets are the lengths of each branch identified at each timepoint.
DOI: 10.6084/m9.figshare.12057069
title: Ipsi EGFP - contra eye stim raw branch lengths

description: Xenopus RGC axon branch dynamics <br>Data generated by Dynamo reconstructions of RGC axons imaged in the optic tectum in darkness and with visual stimulation. These datasets are the lengths of each branch identified at each timepoint.
DOI: 10.6084/m9.figshare.12057075.v1
title: Ipsi EGFP - ipsi eye stim raw branch lengths

description: Xenopus RGC axon branch dynamics <br>Data generated by Dynamo reconstructions of RGC axons imaged in the optic tectum in darkness and with visual stimulation. These datasets are the lengths of each branch identified at each timepoint.
DOI: 10.6084/m9.figshare.12057063
title: Ipsi TeNT - contra eye stim raw branch lengths

description: Xenopus RGC axon branch dynamics <br>Data generated by Dynamo reconstructions of RGC axons imaged in the optic tectum in darkness and with visual stimulation. These datasets are the lengths of each branch identified at each timepoint.
DOI: 10.6084/m9.figshare.12057066
title: Ipsi TeNT - ipsi eye stim raw branch lengths

description: Xenopus RGC axon branch dynamics <br>Data generated by Dynamo reconstructions of RGC axons imaged in the optic tectum in darkness and with visual stimulation. These datasets are the lengths of each branch identified at each timepoint.
DOI: 10.6084/m9.figshare.12057060
title: Ipsi TeNT/Tables for analysis

description: Xenopus RGC axon branch dynamics <br>Processed branch dynamics data (additions/elongations/eliminations/retractions) compared for different visual stimulation conditions. TeNT-expressing axons.
DOI: 10.6084/m9.figshare.12057060.v1
title: Ipsi TeNT/Tables for analysis

description: Xenopus RGC axon branch dynamics <br>Processed branch dynamics data (additions/elongations/eliminations/retractions) compared for different visual stimulation conditions. TeNT-expressing axons.
DOI: 10.6084/m9.figshare.12057063.v1
title: Ipsi TeNT - contra eye stim raw branch lengths

description: Xenopus RGC axon branch dynamics <br>Data generated by Dynamo reconstructions of RGC axons imaged in the optic tectum in darkness and with visual stimulation. These datasets are the lengths of each branch identified at each timepoint.
DOI: 10.6084/m9.figshare.12057066.v1
title: Ipsi TeNT - ipsi eye stim raw branch lengths

description: Xenopus RGC axon branch dynamics <br>Data generated by Dynamo reconstructions of RGC axons imaged in the optic tectum in darkness and with visual stimulation. These datasets are the lengths of each branch identified at each timepoint.
DOI: 10.6084/m9.figshare.12057000
title: Visceral fat index: a novel predictor for coronary collateral circulation

description: ABSTRACT Objective This study was designed to investigate the role of visceral adiposity along with other clinical parameters in predicting poor coronary collateral circulation (CCC) among patients with severe obstructive coronary artery disease (CAD). Subjects and methods A total of 135 patients with severe obstructive CAD and good (n = 70) or poor (n = 65) CCC were included. Data on angiographically detected CCC, the quality criteria for CCC (Rentrop scores) and visceral fat index (VFI) obtained via bioelectrical impedance were compared between good and poor CCC groups. Independent predictors of poor CCC, the correlation between VFI and Rentrop score and the role of VFI in the identification of CCC were analyzed. Results A significant negative correlation was noted between VFI and Rentrop scores (r = -0.668, &lt; 0.001). The presence of hypertension (OR 4.244, 95% CI 1.184 to 15.211, p = 0.026) and higher VFI (OR 1.955, 95% CI 1.342 to 2.848, p &lt; 0.001) were shown to be independent predictors of an increased risk for poor CCC. ROC analysis revealed a VFI &gt; 9 (AUC [area under the curve] (95% CI): 0.898 (0.834-0.943), p &lt; 0.0001) to be a potential predictor of poor CCC with a sensitivity of 95.38% and specificity of 85.71%. Conclusion In conclusion, our findings revealed comorbid hypertension and higher VFI to significantly predict the risk of poor CCC in patients with severe obstructive CAD.
DOI: 10.6084/m9.figshare.12057033
title: mention.net

description: A twitter mention network<br>
DOI: 10.6084/m9.figshare.12057000.v1
title: Visceral fat index: a novel predictor for coronary collateral circulation

description: ABSTRACT Objective This study was designed to investigate the role of visceral adiposity along with other clinical parameters in predicting poor coronary collateral circulation (CCC) among patients with severe obstructive coronary artery disease (CAD). Subjects and methods A total of 135 patients with severe obstructive CAD and good (n = 70) or poor (n = 65) CCC were included. Data on angiographically detected CCC, the quality criteria for CCC (Rentrop scores) and visceral fat index (VFI) obtained via bioelectrical impedance were compared between good and poor CCC groups. Independent predictors of poor CCC, the correlation between VFI and Rentrop score and the role of VFI in the identification of CCC were analyzed. Results A significant negative correlation was noted between VFI and Rentrop scores (r = -0.668, &lt; 0.001). The presence of hypertension (OR 4.244, 95% CI 1.184 to 15.211, p = 0.026) and higher VFI (OR 1.955, 95% CI 1.342 to 2.848, p &lt; 0.001) were shown to be independent predictors of an increased risk for poor CCC. ROC analysis revealed a VFI &gt; 9 (AUC [area under the curve] (95% CI): 0.898 (0.834-0.943), p &lt; 0.0001) to be a potential predictor of poor CCC with a sensitivity of 95.38% and specificity of 85.71%. Conclusion In conclusion, our findings revealed comorbid hypertension and higher VFI to significantly predict the risk of poor CCC in patients with severe obstructive CAD.
DOI: 10.6084/m9.figshare.12057033.v1
title: mention.net

description: A twitter mention network<br>
DOI: 10.6084/m9.figshare.12056991
title: Inflammatory markers in palatine tonsils of children with obstructive sleep apnea syndrome

description: Abstract Introduction Obstrutive sleep apnea syndrome is characterized by repeated episodes of upper airway obstruction, associated with intermittent hypoxia and hypercapnia, and the main risk factor in childhood is adenotonsillar hypertrophy. The lymphocytes in these structures are responsible for local and systemic immune responses. Objective Verify the levels of the inflammatory markers, IL-1β, IL-4, IL-6, IL-8, IL-10, IL-15, TNF-α, CRP and α1-GP, in the tonsils of children with and without obstructive sleep apnea syndrome. Methods This cross-sectional prospective study included 34 children with complains of snoring, difficulty breathing during sleep or recurrent tonsillitis. Patients underwent to a complete otorhinolaryngological examination, nasal endoscopy and polysomnography and were divided into two groups with 17 children each: obstructive sleep apnea syndrome group and control group. All underwent an adenotonsillectomy. Cytokines were measured in the collected tonsils (ELISA and Multiplex methods). Results Statistically significant increasing were observed between IL-8 and IL-10 cytokines of patients with obstructive sleep apnea when compared to the control group; also between c-reactive protein and α1-GP of the tonsils cortical region in children with obstructive sleep apnea syndrome when compared with the medullary region. There were no statistically significant differences for the remaining inflammatory mediators. Conclusion After the analysis of the levels of pro and anti-inflammatory markers (IL-1β, IL-4, IL-6, IL-8, IL-10, Il-15, TNF-α, CRP, α1-GP) in the tonsils, we observed higher levels of markers IL-8 and IL-10 in pediatric patients with obstructive sleep apnea syndrome.
DOI: 10.6084/m9.figshare.12056988
title: Determining an optimal cut-off value for follicle-stimulating hormone to predict microsurgical testicular sperm extraction outcome in patients with non-obstructive azoospermia

description: ABSTRACT Objective To determine the optimal cut-off value for follicle stimulating hormone (FSH) to predict the outcome of microsurgical testicular sperm extraction (micro-TESE) in patients with nonobstructive azoospermia (NOA). Subjects and methods We included a total number of 180 patients with NOA. The serum level of FSH was determined and all the subjects underwent micro-TESE. We determined the optimal cut-off value for FSH and assessed whether the test could be effectively used as a successful predictor of sperm retrieval by calculating the Receiver Operating Characteristic (ROC) area under the curve. Results Overall we included a total number of 171 patients with mean age of 34.3 ± 8.6 years. The micro-TESE was considered to be successful in 79 (43.8%) while it failed in 92 (56.2%) patients. We found that the mean level of serum FSH was significantly higher in group those with failed micro-TEST compared to successful group (p &lt; 0.001). The cut-off value for FSH was calculated to be 14.6 mIU/mL to predictive the outcome of micro-TESE with a sensitivity of 83.5% [73.5%-90.9%] and a specificity of 80.3% [69.5%-88.5%]. At this value, the other parameters were calculated to be PPV, 81.5%; NPV, 82.4; LR+, 4.23; and LR-, 0.21. Conclusions The results of the current study indicate that FSH plasma levels above 14.6 mIU/mL can be considered to be the failure predictor of the micro-TESE in NOA patients.
DOI: 10.6084/m9.figshare.12056991.v1
title: Inflammatory markers in palatine tonsils of children with obstructive sleep apnea syndrome

description: Abstract Introduction Obstrutive sleep apnea syndrome is characterized by repeated episodes of upper airway obstruction, associated with intermittent hypoxia and hypercapnia, and the main risk factor in childhood is adenotonsillar hypertrophy. The lymphocytes in these structures are responsible for local and systemic immune responses. Objective Verify the levels of the inflammatory markers, IL-1β, IL-4, IL-6, IL-8, IL-10, IL-15, TNF-α, CRP and α1-GP, in the tonsils of children with and without obstructive sleep apnea syndrome. Methods This cross-sectional prospective study included 34 children with complains of snoring, difficulty breathing during sleep or recurrent tonsillitis. Patients underwent to a complete otorhinolaryngological examination, nasal endoscopy and polysomnography and were divided into two groups with 17 children each: obstructive sleep apnea syndrome group and control group. All underwent an adenotonsillectomy. Cytokines were measured in the collected tonsils (ELISA and Multiplex methods). Results Statistically significant increasing were observed between IL-8 and IL-10 cytokines of patients with obstructive sleep apnea when compared to the control group; also between c-reactive protein and α1-GP of the tonsils cortical region in children with obstructive sleep apnea syndrome when compared with the medullary region. There were no statistically significant differences for the remaining inflammatory mediators. Conclusion After the analysis of the levels of pro and anti-inflammatory markers (IL-1β, IL-4, IL-6, IL-8, IL-10, Il-15, TNF-α, CRP, α1-GP) in the tonsils, we observed higher levels of markers IL-8 and IL-10 in pediatric patients with obstructive sleep apnea syndrome.
DOI: 10.6084/m9.figshare.12056976
title: Numerical analysis of the effective stiffness of elastomeric bearing pads under precast beams for the limit load of lateral instability

description: Abstract Precast concrete girders on bearing pads are subjected to instability depending on several variables such as span length, initial imperfections and bearing pads behavior. On this paper, numerical models are developed in order to assess the instability limit loads and the rotational stiffnesses of the pads in many combinations of span length, cross section of the girder and lateral sweep. The lift off phenomenon is considered in each analysis by a bearing pad model composed by springs with compression only behavior, with good results in comparison with the experimental values of the technical literature. The increase in spans and initial imperfections causes a decrease in the rollover limit load. The lift off effect is aggravated as the lateral eccentricities increase. In the analyzed combinations, the reduction of the rotational stiffness is about 37% for the critical situation, which span length about 40 m and lateral sweep of L/300, with loss of contact between 50% and 60%.
DOI: 10.6084/m9.figshare.12056982
title: Two variants of the Nutritional Risk in the Critically Ill Score as predictors of mortality in Intensive Care Unit patients at a Brazilian University Hospital

description: ABSTRACT Objective To evaluate the agreement between the modified version of the Nutritional Risk in the Critically Ill Score (without Interleukin-6) and a variant composed of C-Reactive Protein as well as its capacity to predict mortality. Methods A prospective cohort study was carried out with 315 patients in an Intensive Care Unit of a university hospital from October 2017 to April 2018. The agreement between the instruments was evaluated using the Kappa test. The predictive capacity for estimating mortality was assessed with the Receiver Operating Characteristic curve. Results The critical patients involved in the study had a mean age of 60.8±16.3 years and 53.5% were female. Most patients had C-Reactive Protein levels ?10mg/dL (n=263, 83.5%) and their admission in the Intensive Care Unit was medical (n=219, 69.5%). The prevalence of mortality was observed in 41.0% of the evaluated patients. The proportions at high nutritional risk according to Nutritional Risk in the Critically Ill without Interleukin-6 and with C-Reactive Protein were 57.5% and 55.6%, respectively. The tools showed strong and significant agreement(Kappa=0.935; p=0.020) and satisfactory performances in predicting mortality (area under the curve 0.695 [0.636-0.754] and 0.699 [0.640-0.758]). Conclusion Both versions of the Nutritional Risk in the Critically Ill tool show a satisfactory agreement and performance as predictors of mortality in critically ill patients. Further analysis of this variant and the association between nutrition adequacy and mortality is needed.