cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.19899693.v1
title: The benefit of Silybum marianum in ethanol-induced reprotoxicity of male Wistar rat

description: Abstract This study investigates the toxic effects of ethanol (Eth) on the reproductive system of male rats and the possible protective role of Silybum marianum seeds-infused solution (SMI) over six consecutive weeks of administration. Animals were divided into the following groups: control, SMI positive control (200 mg/kg/day), Eth1 (1 g/kg/day), Eth2 (2 g/kg/day), Eth1+SMI, and Eth2+SMI. Plasma testosterone concentration, epididymal spermatozoa biology, and testicular and epididymal MDA, GSH and GPx levels were evaluated. The results indicated a significant decrease in testis and epididymis weight, testosterone level, sperm concentration, sperm vitality and sperm motility (total motility, progressive motility, curvilinear velocity, straight-line velocity, velocity average path, beat cross frequency, and lateral head displacement) in both Eth1 and Eth2 compared to the control groups and the combined-treatment groups (Eth1+SMI and Eth2+SMI). Furthermore, results showed a significant elevation in MDA concentration with a significant decrease of testicular and epididymal GSH concentration and GPx activity in theEth1 and Eth2 groups compared to the combined-treatment groups. The administration of SMI succeeded in improving the parameters cited above in the combined-treatment groups compared to the Eth1 and Eth2 groups, and bring them to the levels seen in the control groups. To conclude, SMI has clearly protected reproductive indices against ethanol-induced reprotoxicity in male rats
DOI: 10.6084/m9.figshare.19899695
title: Natural ventilation and thermal performance under different opening configurations in a classroom

description: Abstract In school buildings located in hot tropical areas, it is a common practice to use mechanical climate control systems to avoid heat stress. The use of passive design strategies is of paramount importance for the achievement of thermal comfort with low energy consumption. Hence, buildings’ openings play an important role, as they have an impact on the amount of solar radiation received and on the internal air flow distribution pattern. The objective of this study was to evaluate the thermal performance in classrooms with different window and door model configurations in Vitória/ES and Belém/PA, Brazil. Simulations of thermal performance were conducted to analyse the intensity of thermal discomfort and energy consumption, while the aid of Computational Fluid Dynamics tools enabled the verification of details of the air velocity and temperature fields. The results show that the addition of a ventilated sill increases air velocity at the inlet opening and significantly improves thermal performance in the classroom. The use of brise-soleil reduces energy consumption in the classrooms in Belém and Vitória by up to 50% and 13%, respectively. The study helps in the selection of more efficient openings, adapted to the climatic conditions of each region.
DOI: 10.6084/m9.figshare.19899695.v1
title: Natural ventilation and thermal performance under different opening configurations in a classroom

description: Abstract In school buildings located in hot tropical areas, it is a common practice to use mechanical climate control systems to avoid heat stress. The use of passive design strategies is of paramount importance for the achievement of thermal comfort with low energy consumption. Hence, buildings’ openings play an important role, as they have an impact on the amount of solar radiation received and on the internal air flow distribution pattern. The objective of this study was to evaluate the thermal performance in classrooms with different window and door model configurations in Vitória/ES and Belém/PA, Brazil. Simulations of thermal performance were conducted to analyse the intensity of thermal discomfort and energy consumption, while the aid of Computational Fluid Dynamics tools enabled the verification of details of the air velocity and temperature fields. The results show that the addition of a ventilated sill increases air velocity at the inlet opening and significantly improves thermal performance in the classroom. The use of brise-soleil reduces energy consumption in the classrooms in Belém and Vitória by up to 50% and 13%, respectively. The study helps in the selection of more efficient openings, adapted to the climatic conditions of each region.
DOI: 10.6084/m9.figshare.19899708
title: Responsive architecture: a bibliometric analysis of scientific production

description: Abstract Responsive architecture deals with the integration of data and physical adaptations between building and environment. The importance of the building envelope as a responsive construction system is one of the mostly investigated issues in the research field of architecture. Thisliterature review and bibliometric analysis took into account type, quantity and year of publication, co-occurrence of terms, authors and affiliations. Output regarding conferences and journals, authors and higher-education institutions, and knowledge fields related to responsive architecture were highlighted. The participation of conference papers is more evident from a quantitative point of view; its percentage of the sample was around 55%. Automation in Construction is the most significant journal reaching 17% from the total journal output. The Netherlands and United Kingdom are the most cited countries on the subject matter. The study confirmed that responsive architecture has relevant interactions between different areas of knowledge, from computational science, robotics, civil engineering, urban design, product design to sustainable architecture, hence exhibiting a pronounced collaborative and multidisciplinary approach. Results from the systematic review and bibliometric analysis allow us to stress the need for a continued assessment of scientific production in the area and also for further research initiatives aimed at database analyses.
DOI: 10.6084/m9.figshare.19899708.v1
title: Responsive architecture: a bibliometric analysis of scientific production

description: Abstract Responsive architecture deals with the integration of data and physical adaptations between building and environment. The importance of the building envelope as a responsive construction system is one of the mostly investigated issues in the research field of architecture. Thisliterature review and bibliometric analysis took into account type, quantity and year of publication, co-occurrence of terms, authors and affiliations. Output regarding conferences and journals, authors and higher-education institutions, and knowledge fields related to responsive architecture were highlighted. The participation of conference papers is more evident from a quantitative point of view; its percentage of the sample was around 55%. Automation in Construction is the most significant journal reaching 17% from the total journal output. The Netherlands and United Kingdom are the most cited countries on the subject matter. The study confirmed that responsive architecture has relevant interactions between different areas of knowledge, from computational science, robotics, civil engineering, urban design, product design to sustainable architecture, hence exhibiting a pronounced collaborative and multidisciplinary approach. Results from the systematic review and bibliometric analysis allow us to stress the need for a continued assessment of scientific production in the area and also for further research initiatives aimed at database analyses.
DOI: 10.6084/m9.figshare.19899719
title: Captopril oral solution for pediatric use: formulation, stability study and palatability assessment in vivo

description: Abstract The aim of this work was to develop an oral solution of captopril at 5 mg/mL preservative-free. Two formulations were prepared, one containing sweetener (formulation 1) and the other without this excipient (formulation 2). The results found of validation parameters from analytical method performed by HPLC for captopril were, linearity 0.9998, the limit of detection 15.71 µg/mL, the limit of quantification 47.60 µg/mL, repeatability 1.05%, intermediate precision 2.42%, accuracy intraday 101,53%, accuracy inter-day 99.85%. Moreover, the results found for captopril disulfide were, linearity 0.9999, limit of detection 0.65 µg/mL, limit of quantification 1.96 µg/mL, repeatability 2.28%, intermediate precision 1.51%, accuracy intraday 101.36%, accuracy inter-day 100.29%. The appearance of formulations was clear and colorless, pH measures were 3.12 and 3.04, dosage of captopril and captopril disulfide were 99.45% and 99.82%, 0.24% and 0.12% for formulation 1 and formulation 2, respectively. The stability study demonstrated that the concentration of captopril and captopril disulfide in the formulations was &gt; 90% and below 3%, respectively. The in vivo palatability study in animals and humans showed that Formulation 1 containing the sweetener had better acceptance. Thus, the sweetener was able to improve the unpleasant taste of the formulation.
DOI: 10.6084/m9.figshare.19899719.v1
title: Captopril oral solution for pediatric use: formulation, stability study and palatability assessment in vivo

description: Abstract The aim of this work was to develop an oral solution of captopril at 5 mg/mL preservative-free. Two formulations were prepared, one containing sweetener (formulation 1) and the other without this excipient (formulation 2). The results found of validation parameters from analytical method performed by HPLC for captopril were, linearity 0.9998, the limit of detection 15.71 µg/mL, the limit of quantification 47.60 µg/mL, repeatability 1.05%, intermediate precision 2.42%, accuracy intraday 101,53%, accuracy inter-day 99.85%. Moreover, the results found for captopril disulfide were, linearity 0.9999, limit of detection 0.65 µg/mL, limit of quantification 1.96 µg/mL, repeatability 2.28%, intermediate precision 1.51%, accuracy intraday 101.36%, accuracy inter-day 100.29%. The appearance of formulations was clear and colorless, pH measures were 3.12 and 3.04, dosage of captopril and captopril disulfide were 99.45% and 99.82%, 0.24% and 0.12% for formulation 1 and formulation 2, respectively. The stability study demonstrated that the concentration of captopril and captopril disulfide in the formulations was &gt; 90% and below 3%, respectively. The in vivo palatability study in animals and humans showed that Formulation 1 containing the sweetener had better acceptance. Thus, the sweetener was able to improve the unpleasant taste of the formulation.
DOI: 10.6084/m9.figshare.19899728
title: Chemical composition and biological activity of Baccharis erioclada DC. essential oil

description: Abstract The chemically complex essential oils of Baccharis species are associated with several biological activities, such as antimicrobial and antiulcerous properties. However, few studies have investigated Baccharis erioclada DC. Therefore, in this study, we aimed to characterize the essential oil of B. erioclada and evaluate its antioxidant, antimicrobial, and hemolytic potential. The essential oil was extracted by hydrodistillation using a Clevenger apparatus and analyzed via gas chromatography-mass spectrometry (GC-MS). Phosphomolybdenum complex formation, reducing antioxidant power, and thiobarbituric acid reactive substances (TBARS) methods were used to determine antioxidant potential. To evaluate the essential oil’s antimicrobial activity, minimum inhibitory concentrations (MIC) in Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, and Candida albicans were calculated. Hemolytic activity was determined in sheep red blood cells. Thirty-one compounds were identified via GC-MS analysis, representing 81.60% of the total essential oil. These compounds included: turmerone (27.97%), fokienol (13.47%), ledol (9.78%), and santalol (5.35%). The class of compounds identified was the oxygenated sesquiterpenes (62.52%). Antioxidant activity was confirmed via phosphomolybdenum complex formation and TBARS methods. Moderate antimicrobial activity and low hemolysis rates were displayed at concentrations of 250 and 500 μg/mL.
DOI: 10.6084/m9.figshare.19899728.v1
title: Chemical composition and biological activity of Baccharis erioclada DC. essential oil

description: Abstract The chemically complex essential oils of Baccharis species are associated with several biological activities, such as antimicrobial and antiulcerous properties. However, few studies have investigated Baccharis erioclada DC. Therefore, in this study, we aimed to characterize the essential oil of B. erioclada and evaluate its antioxidant, antimicrobial, and hemolytic potential. The essential oil was extracted by hydrodistillation using a Clevenger apparatus and analyzed via gas chromatography-mass spectrometry (GC-MS). Phosphomolybdenum complex formation, reducing antioxidant power, and thiobarbituric acid reactive substances (TBARS) methods were used to determine antioxidant potential. To evaluate the essential oil’s antimicrobial activity, minimum inhibitory concentrations (MIC) in Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, and Candida albicans were calculated. Hemolytic activity was determined in sheep red blood cells. Thirty-one compounds were identified via GC-MS analysis, representing 81.60% of the total essential oil. These compounds included: turmerone (27.97%), fokienol (13.47%), ledol (9.78%), and santalol (5.35%). The class of compounds identified was the oxygenated sesquiterpenes (62.52%). Antioxidant activity was confirmed via phosphomolybdenum complex formation and TBARS methods. Moderate antimicrobial activity and low hemolysis rates were displayed at concentrations of 250 and 500 μg/mL.
DOI: 10.6084/m9.figshare.19899746
title: Topology Optimization – unconventional approaches using the Generalized Finite Element Method and the Stable Generalized Finite Element Method

description: Abstract The Structural Optimization process has an increasing importance in industry and academic fields, assisting in the development of designs at the initial stages of a project. Nowadays, the structural optimization methodology can be conducted by Topology Optimization Method (TOM), which is an efficiently combination of the Finite Element Method (FEM) with an optimization algorithm, in order to find the optimized material distribution inside a given design domain subjected to a set of constraints. Application of the FEM in TOM suffers from a series of instability problems, being one of them the checkerboard pattern. This paper investigates the impact of the Generalized Finite Element Method (GFEM) and Stable Generalized Finite Element Method (SGFEM) in the implementation of the TOM algorithm. This work shows that these unconventional FEM formulations are able to solve most of the checkerboard pattern problem when combined with an enriched mesh designed specifically to each example evaluated. Significant improvement in results of the topology optimization is achieved when compared to the conventional formulation of TOM.
DOI: 10.6084/m9.figshare.19899746.v1
title: Topology Optimization – unconventional approaches using the Generalized Finite Element Method and the Stable Generalized Finite Element Method

description: Abstract The Structural Optimization process has an increasing importance in industry and academic fields, assisting in the development of designs at the initial stages of a project. Nowadays, the structural optimization methodology can be conducted by Topology Optimization Method (TOM), which is an efficiently combination of the Finite Element Method (FEM) with an optimization algorithm, in order to find the optimized material distribution inside a given design domain subjected to a set of constraints. Application of the FEM in TOM suffers from a series of instability problems, being one of them the checkerboard pattern. This paper investigates the impact of the Generalized Finite Element Method (GFEM) and Stable Generalized Finite Element Method (SGFEM) in the implementation of the TOM algorithm. This work shows that these unconventional FEM formulations are able to solve most of the checkerboard pattern problem when combined with an enriched mesh designed specifically to each example evaluated. Significant improvement in results of the topology optimization is achieved when compared to the conventional formulation of TOM.
DOI: 10.5281/zenodo.6586678
title: Dataset for learning to predict the suitability of experts for statements

description: Dataset consisting of 1,700 (statement, expert) pairs for learning and evaluating whether a researcher can be cited as an expert for a statement.<br> A total of 170 statements were extracted from the dataset "De Argumentenfabriek" [1].<br> For each statement, two experts were manually selected from Google-Scholar and their data extracted.<br> In addition, for each of the 170 statements, 8 experts were randomly picked from the pool of 340 scientists and then manually assessed on a scale from 0 to 2 by two to three annotators whether that scientist can be cited as an expert for the statement. [1]: https://zenodo.org/record/4813727<br>
DOI: 10.5281/zenodo.6586677
title: Dataset for learning to predict the suitability of experts for statements

description: Dataset consisting of 1,700 (statement, expert) pairs for learning and evaluating whether a researcher can be cited as an expert for a statement.<br> A total of 170 statements were extracted from the dataset "De Argumentenfabriek" [1].<br> For each statement, two experts were manually selected from Google-Scholar and their data extracted.<br> In addition, for each of the 170 statements, 8 experts were randomly picked from the pool of 340 scientists and then manually assessed on a scale from 0 to 2 by two to three annotators whether that scientist can be cited as an expert for the statement. [1]: https://zenodo.org/record/4813727<br>
DOI: 10.6084/m9.figshare.19899786
title: Therapeutic approach in Class I malocclusion with impacted maxillary canines

description: ABSTRACT Objective: To emphasize the importance of diagnosis and discuss the therapeutic approaches that can be used in the orthodontic treatment of Class I malocclusion associated with two impacted maxillary canines. The opening of spaces for traction of these teeth by means of rapid maxillary expansion or extraction of maxillary premolars was contraindicated in the case reported. Therefore, it was decided to open spaces with projection of incisors. Results: The obtained results were satisfactory, as a good occlusion was obtained, with adequate functional guides, as well as an improvement in the facial appearance. Conclusion: The projection of the incisors prior to traction of the impacted maxillary canines proved to be a valid option in the case described. Ten years after completion of treatment, the case is stable, maintaining periodontal health.
DOI: 10.6084/m9.figshare.19899786.v1
title: Therapeutic approach in Class I malocclusion with impacted maxillary canines

description: ABSTRACT Objective: To emphasize the importance of diagnosis and discuss the therapeutic approaches that can be used in the orthodontic treatment of Class I malocclusion associated with two impacted maxillary canines. The opening of spaces for traction of these teeth by means of rapid maxillary expansion or extraction of maxillary premolars was contraindicated in the case reported. Therefore, it was decided to open spaces with projection of incisors. Results: The obtained results were satisfactory, as a good occlusion was obtained, with adequate functional guides, as well as an improvement in the facial appearance. Conclusion: The projection of the incisors prior to traction of the impacted maxillary canines proved to be a valid option in the case described. Ten years after completion of treatment, the case is stable, maintaining periodontal health.
DOI: 10.6084/m9.figshare.19898714
title: Evaluation of cerebral hemodynamics by transcranial Doppler ultrasonography and its correlation with intracranial pressure in an animal model of intracranial hypertension

description: ABSTRACT Background: Transcranial Doppler has been tested in the evaluation of cerebral hemodynamics as a non-invasive assessment of intracranial pressure (ICP), but there is controversy in the literature about its actual benefit and usefulness in this situation. Objective: To investigate cerebral blood flow assessed by Doppler technique and correlate with the variations of the ICP in the acute phase of intracranial hypertension in an animal model. Methods: An experimental animal model of intracranial hypertension was used. The experiment consisted of two groups of animals in which intracranial balloons were implanted and inflated with 4 mL (A) and 7 mL (B) for controlled simulation of different volumes of hematoma. The values of ICP and Doppler parameters (systolic [FVs], diastolic [FVd], and mean [FVm] cerebral blood flow velocities and pulsatility index [PI]) were collected during the entire procedure (before and during hematoma simulations and venous hypertonic saline infusion intervention). Comparisons between Doppler parameters and ICP monitoring were performed. Results: Twenty pigs were studied, 10 in group A and 10 in group B. A significant correlation between PI and ICP was obtained, especially shortly after abrupt elevation of ICP. There was no correlation between ICP and FVs, FVd or FVm separately. There was also no significant change in ICP after intravenous infusion of hypertonic saline solution. Conclusions: These results demonstrate the potential of PI as a parameter for the evaluation of patients with suspected ICP elevation.
DOI: 10.6084/m9.figshare.19899769.v1
title: Regional Assets

description: This data provides the asset value across regions, industries and times in the United Kingdom from 1997 to 2020.
DOI: 10.6084/m9.figshare.19899769
title: Regional Assets

description: This data provides the asset value across regions, industries and times in the United Kingdom from 1997 to 2020.
DOI: 10.6084/m9.figshare.19899830
title: Fractures of the appendicular skeleton and criteria for their surgical management: pictorial essay

description: Abstract The high prevalence of fractures and the essential role that imaging examinations play in this scenario require the radiologist to be familiar with their main patterns, especially those of fractures for which the management is essentially surgical. This pictorial essay presents a series of illustrative cases and a brief review of the literature, the aim being to demonstrate some of the main fractures of the appendicular skeleton that require surgical management, grouped, didactically, by the joint affected. Radiographic and computed tomography studies of illustrative cases were selected from the imaging archives of our facility.
DOI: 10.6084/m9.figshare.19899830.v1
title: Fractures of the appendicular skeleton and criteria for their surgical management: pictorial essay

description: Abstract The high prevalence of fractures and the essential role that imaging examinations play in this scenario require the radiologist to be familiar with their main patterns, especially those of fractures for which the management is essentially surgical. This pictorial essay presents a series of illustrative cases and a brief review of the literature, the aim being to demonstrate some of the main fractures of the appendicular skeleton that require surgical management, grouped, didactically, by the joint affected. Radiographic and computed tomography studies of illustrative cases were selected from the imaging archives of our facility.