cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.16998284
title: Long-term corticosteroid-induced chronic glaucoma model produced by intracameral injection of dexamethasone-loaded PLGA microspheres

description: To evaluate a new chronic glaucoma model produced by intracameral injection of dexamethasone-loaded poly lactic-co-glycolic acid microspheres (Dex-PLGA-Ms) over six months. Healthy rats received two injections (at baseline and Week 4) of Dex-PLGA-Ms into the anterior chamber of the right eye. Clinical signs and intraocular pressure (IOP) were weekly recorded. The structure of the retina and optic nerve was <i>in vivo</i> evaluated using optical coherence tomography (OCT) every two weeks and functionally using dark- and light-adapted electroretinography at 0–12–24 weeks. Histological studies were also performed. IOP progressively increased up to hypertension (23.22 ± 3.63 mmHg) in both eyes but did so later in left eyes. OCT quantified a decrease in full-thickness retina posterior pole (R), retinal-nerve-fiber layer (RNFL), and ganglion-cell layer (GCL) thickness up to 24 weeks. Right eyes showed higher neuroretinal thickness loss up to week 8. RNFL experienced the highest percentage thickness loss at the inferior-superior axis, while in GCL the inner sectors of the horizontal axis (Nasal-Temporal) suffered the greatest decrease in thickness. Retinal ganglion cell, photoreceptor, and intermediate cell functionality decreased over time. Increased deposition of collagen IV was also found in zonular fibers and the ciliary body. This work shows the usefulness of drug delivery systems, not to treat pathology but to induce it. Only two injections of Dex-PLGA-Ms in the anterior chamber of rat eyes were enough to progressively create ocular hypertension and subsequent functional and structural neuroretinal degeneration, at least over 6 months.
DOI: 10.6084/m9.figshare.16998284.v1
title: Long-term corticosteroid-induced chronic glaucoma model produced by intracameral injection of dexamethasone-loaded PLGA microspheres

description: To evaluate a new chronic glaucoma model produced by intracameral injection of dexamethasone-loaded poly lactic-co-glycolic acid microspheres (Dex-PLGA-Ms) over six months. Healthy rats received two injections (at baseline and Week 4) of Dex-PLGA-Ms into the anterior chamber of the right eye. Clinical signs and intraocular pressure (IOP) were weekly recorded. The structure of the retina and optic nerve was <i>in vivo</i> evaluated using optical coherence tomography (OCT) every two weeks and functionally using dark- and light-adapted electroretinography at 0–12–24 weeks. Histological studies were also performed. IOP progressively increased up to hypertension (23.22 ± 3.63 mmHg) in both eyes but did so later in left eyes. OCT quantified a decrease in full-thickness retina posterior pole (R), retinal-nerve-fiber layer (RNFL), and ganglion-cell layer (GCL) thickness up to 24 weeks. Right eyes showed higher neuroretinal thickness loss up to week 8. RNFL experienced the highest percentage thickness loss at the inferior-superior axis, while in GCL the inner sectors of the horizontal axis (Nasal-Temporal) suffered the greatest decrease in thickness. Retinal ganglion cell, photoreceptor, and intermediate cell functionality decreased over time. Increased deposition of collagen IV was also found in zonular fibers and the ciliary body. This work shows the usefulness of drug delivery systems, not to treat pathology but to induce it. Only two injections of Dex-PLGA-Ms in the anterior chamber of rat eyes were enough to progressively create ocular hypertension and subsequent functional and structural neuroretinal degeneration, at least over 6 months.
DOI: 10.6084/m9.figshare.13482751
title: The relevance of nanotechnology, hepato-protective agents in reducing the toxicity and augmenting the bioavailability of isotretinoin

description: Acne Vulgaris is one of the most common chronic inflammatory skin disorders that affect majority of teen-agers worldwide. Isotretinoin (ITT) is the drug of choice in the management of acne, but, it suffers from serious side-effects including hepatotoxicity, and some psychological disturbances following its oral intake. The objective of this study was to develop and optimize ITT loaded nanoemulsions (ITT-SNEDDS) and to incorporate resveratrol (RSV)in optimum formulation to decrease ITT side effects The ITT solubility was first tested in various essential oils, surfactants, and co-surfactants to select the essential nanoemulsion ingredients. Mixture design was applied to study the effect of independent variables and their interactions on the selected dependent responses. The developed ITT-SNEDDS were characterized for their globule size and <i>ex vivo</i> permeation. The optimized batch was further loaded with RSV and evaluated for in vitro and <i>ex vivo</i> permeation and for in vivo hepatotoxicity. The developed ITT-SNEDDS exhibited globule size below 300 nm, up to 272.27 ± 7.12 mcg/cm<sup>2</sup>.h and 61.27 ± 2.83% of steady-state flux (J<sub>SS</sub>) and permeability % respectively. Optimum formulation consisted of 0.15 g oil mixture, 0.6 g of surfactant (Labrasol), and 0.250 g co-surfactant (Transcutol). Permeability studies confirmed the enhanced permeation percentage of ITT (40.77 ± 1.18%), and RSV (29.94 ± 2.02%) from optimized formulation, with enhanced steady-state flux (J<sub>SS</sub>). In vivo studies demonstrated the superior hepatoprotective activity of optimized formulation compared to a different drug formulations and marketed product. Therefore, RVS loaded ITT-SNEDDS might be a successful strategy for acne management with improved action, and minimum side effects.
DOI: 10.6084/m9.figshare.13482751.v2
title: The relevance of nanotechnology, hepato-protective agents in reducing the toxicity and augmenting the bioavailability of isotretinoin

description: Acne Vulgaris is one of the most common chronic inflammatory skin disorders that affect majority of teen-agers worldwide. Isotretinoin (ITT) is the drug of choice in the management of acne, but, it suffers from serious side-effects including hepatotoxicity, and some psychological disturbances following its oral intake. The objective of this study was to develop and optimize ITT loaded nanoemulsions (ITT-SNEDDS) and to incorporate resveratrol (RSV)in optimum formulation to decrease ITT side effects The ITT solubility was first tested in various essential oils, surfactants, and co-surfactants to select the essential nanoemulsion ingredients. Mixture design was applied to study the effect of independent variables and their interactions on the selected dependent responses. The developed ITT-SNEDDS were characterized for their globule size and <i>ex vivo</i> permeation. The optimized batch was further loaded with RSV and evaluated for in vitro and <i>ex vivo</i> permeation and for in vivo hepatotoxicity. The developed ITT-SNEDDS exhibited globule size below 300 nm, up to 272.27 ± 7.12 mcg/cm<sup>2</sup>.h and 61.27 ± 2.83% of steady-state flux (J<sub>SS</sub>) and permeability % respectively. Optimum formulation consisted of 0.15 g oil mixture, 0.6 g of surfactant (Labrasol), and 0.250 g co-surfactant (Transcutol). Permeability studies confirmed the enhanced permeation percentage of ITT (40.77 ± 1.18%), and RSV (29.94 ± 2.02%) from optimized formulation, with enhanced steady-state flux (J<sub>SS</sub>). In vivo studies demonstrated the superior hepatoprotective activity of optimized formulation compared to a different drug formulations and marketed product. Therefore, RVS loaded ITT-SNEDDS might be a successful strategy for acne management with improved action, and minimum side effects.
DOI: 10.6084/m9.figshare.13482751.v1
title: The relevance of nanotechnology, hepato-protective agents in reducing the toxicity and augmenting the bioavailability of isotretinoin

description: Acne Vulgaris is one of the most common chronic inflammatory skin disorders that affect majority of teen-agers worldwide. Isotretinoin (ITT) is the drug of choice in the management of acne, but, it suffers from serious side-effects including hepatotoxicity, and some psychological disturbances following its oral intake. The objective of this study was to develop and optimize ITT loaded nanoemulsions (ITT-SNEDDS) and to incorporate resveratrol (RSV)in optimum formulation to decrease ITT side effects The ITT solubility was first tested in various essential oils, surfactants, and co-surfactants to select the essential nanoemulsion ingredients. Mixture design was applied to study the effect of independent variables and their interactions on the selected dependent responses. The developed ITT-SNEDDS were characterized for their globule size and <i>ex vivo</i> permeation. The optimized batch was further loaded with RSV and evaluated for in vitro and <i>ex vivo</i> permeation and for in vivo hepatotoxicity. The developed ITT-SNEDDS exhibited globule size below 300 nm, up to 272.27 ± 7.12 mcg/cm<sup>2</sup>.h and 61.27 ± 2.83% of steady-state flux (J<sub>SS</sub>) and permeability % respectively. Optimum formulation consisted of 0.15 g oil mixture, 0.6 g of surfactant (Labrasol), and 0.250 g co-surfactant (Transcutol). Permeability studies confirmed the enhanced permeation percentage of ITT (40.77 ± 1.18%), and RSV (29.94 ± 2.02%) from optimized formulation, with enhanced steady-state flux (J<sub>SS</sub>). In vivo studies demonstrated the superior hepatoprotective activity of optimized formulation compared to a different drug formulations and marketed product. Therefore, RVS loaded ITT-SNEDDS might be a successful strategy for acne management with improved action, and minimum side effects.
DOI: 10.6084/m9.figshare.14435644
title: Inhalation delivery dramatically improves the efficacy of topotecan for the treatment of local and distant lung cancer

description: Topotecan is potent anti-cancer drug approved for various malignancies but hematopoietic toxicities undermine its wider application and use of its most effective dose. This study aims to improve these limitations through inhalation-delivery. The pharmacokinetics, efficacy, and toxicity of 2–5 times lower inhalation doses of topotecan dry-powder were compared with the standard intravenous (IV) delivery once/twice-a-week. Human-derived EGFR-mutant (H1975), KRAS-mutant (A549), and EGFR/KRAS wild-type (H358) orthotopic and distant lung tumors were evaluated in murine models. Inhalation of 1 mg/kg topotecan significantly improved the half-life and drug exposure (area under the curve, AUC) compared to 5 mg/kg via IV-delivery. AUCs (h*ng/mL) for inhaled/IV topotecan in plasma, lung, liver, and brain were, 831/888, 60,000/1080, 8380/4000, and 297/15, respectively; while the half-life was also greatly increased in these tissues. The average lung tumor burden of H358-derived tumors was reduced from 15.0 g to 8.4 g (44%) in rats treated once-a-week with 2 mg/kg IV and 1.8 g (88%) with 1 mg/kg inhaled topotecan, corroborating previous findings using A549- and H1975-derived orthotopic lung tumors. Importantly, inhaled topotecan showed superior efficacy in suppressing lung tumors at distant sites. The growth of H1975- and H358-derived subcutaneous xenografts were completely arrested and A549-derived tumors were significantly reduced in mice treated twice-a-week with 1 mg/kg inhaled topotecan compared to a minor (H1975 and H358) or no reduction (A549) with twice-a-week 5 mg/kg IV topotecan.
DOI: 10.6084/m9.figshare.14435644.v1
title: Inhalation delivery dramatically improves the efficacy of topotecan for the treatment of local and distant lung cancer

description: Topotecan is potent anti-cancer drug approved for various malignancies but hematopoietic toxicities undermine its wider application and use of its most effective dose. This study aims to improve these limitations through inhalation-delivery. The pharmacokinetics, efficacy, and toxicity of 2–5 times lower inhalation doses of topotecan dry-powder were compared with the standard intravenous (IV) delivery once/twice-a-week. Human-derived EGFR-mutant (H1975), KRAS-mutant (A549), and EGFR/KRAS wild-type (H358) orthotopic and distant lung tumors were evaluated in murine models. Inhalation of 1 mg/kg topotecan significantly improved the half-life and drug exposure (area under the curve, AUC) compared to 5 mg/kg via IV-delivery. AUCs (h*ng/mL) for inhaled/IV topotecan in plasma, lung, liver, and brain were, 831/888, 60,000/1080, 8380/4000, and 297/15, respectively; while the half-life was also greatly increased in these tissues. The average lung tumor burden of H358-derived tumors was reduced from 15.0 g to 8.4 g (44%) in rats treated once-a-week with 2 mg/kg IV and 1.8 g (88%) with 1 mg/kg inhaled topotecan, corroborating previous findings using A549- and H1975-derived orthotopic lung tumors. Importantly, inhaled topotecan showed superior efficacy in suppressing lung tumors at distant sites. The growth of H1975- and H358-derived subcutaneous xenografts were completely arrested and A549-derived tumors were significantly reduced in mice treated twice-a-week with 1 mg/kg inhaled topotecan compared to a minor (H1975 and H358) or no reduction (A549) with twice-a-week 5 mg/kg IV topotecan.
DOI: 10.58032/agh/ys7pee
title: SaltPreCO2 - Crystal growth in microfluidic chip

description: Microscopic photos obtained by hi speed camera FASTEC IL5 and OLYMPUS transmitive microscope. Crystal growth observation for brine displacment by CO2 in microfludic chip micronit with rock structure during 24 hours. Hydrophilic and hydrophobic chip used. Pressure 20 bar flowrate 2 ml/min CO2. Ambient temperature. Data collected using Fastec FasMotion software.
DOI: 10.1285/i20705948v16n3p519
title: Bayesian Estimation of Parameter For Different Loss Functions Using Progressive Type-II Censored Data

description: In this present work, we are going to show the various useful propertiesof the existing distribution known as MG_Exp(ε)-distribution which have notquoted by the host authors like moments, mean deviation about mean, meandeviation about median, order statistics, count of uncertainty. Estimation procedures have been adopted under Bayesian estimation for progressive Type-II censored case. Simulation study has also been carried out to judge the behaviour of the Bayes estimator at the long-run. Performance of the Bayes estimators and their posterior risks of the considered loss functions have been obtained, reported and compared for the considered values of sample size, effective sample size, parameter and removals. The comparison of Bayes estimators of all 6 chosen loss functions have been done on the groundof lowest posterior risks.
DOI: 10.1285/i20705948v16n3p541
title: The Formation of Portfolio with Fuzzy Approach and Multi-objective Method

description: Forming a portfolio in the investment process is a crucial component. Itis because investors want maximum profi t while expecting a minimum levelof risk. The portfolio composition is inseparable from the weighting of eachobserved stock. In fact, mathematically, there are still problems when tryingto fulfi ll the preferences that investors want. The research objective was theformation of a portfolio using a fuzzy approach and a multi-objective method.This model simultaneously maximized the return and risk of the preparedportfolio. The result was the formation of a portfolio with two categories,namely risk-seeking and risk-averse, equipped with a λ value of each method,the weight of each stock, the expected return, and risk. Parameter λ wasthe value obtained from selecting the risk level determined by the investor.Parameter λ was used to assess the level of risk and the expected return onthe portfolio preparation. The last section compared the weights, expectedreturn, and risk values of the two methods. As a result, investors in therisk seeker category have the potential to get higher expected returns whenusing the multi-objective method. In contrast, the fuzzy approach producesthe possibility of a higher expected return for investors in the risk-aversecategory.
DOI: 10.5281/zenodo.10848102
title: Genomic spectrograms of subsamplings from complete sequences of SARS-CoV-2
DOI: 10.5281/zenodo.10848103
title: Genomic spectrograms of subsamplings from complete sequences of SARS-CoV-2
DOI: 10.1285/i20705948v16n3p564
title: Generalized Topp-Leone-G power series class of distributions: properties and applications

description: This note is concerned with the construction, development and applications of a new class of distributions referred to as the Generalized Topp-Leone-G Power Series class of distributions. More importantly, this new generalized class of distributions can be expressed as an infinite linear combination of exponentiated-G distributions, which allows us to develop and obtain the important statistical and mathematical properties. Monte Carlo simulations are conducted to established the consistency of the estimation process. Applications in several areas are presented to illustrate the importance and usefulness of this new class of distributions.
DOI: 10.5281/zenodo.10848663
title: Interviewing users of services of selected urban areas (Granada)

description: As part of the EU project SAFE (https://eusafe.fa.uni-lj.si/), University of Granada investigated living conditions and infrastructure offers in Granada (Spain) in order to work out possible suggestions for improvement. Students of University of Granada conducted a survey in Granada in March 2024. The dataset is a compilation of the raw data.
DOI: 10.5281/zenodo.10848664
title: Interviewing users of services of selected urban areas (Granada)

description: As part of the EU project SAFE (https://eusafe.fa.uni-lj.si/), University of Granada investigated living conditions and infrastructure offers in Granada (Spain) in order to work out possible suggestions for improvement. Students of University of Granada conducted a survey in Granada in March 2024. The dataset is a compilation of the raw data.
DOI: 10.1285/i20705948v16n3p614
title: A New Two-parameter-G Family Distribution: Properties and Applications

description: In this paper, a new family of lifetime distributions called new two-parameter-G distribution is introduced. This family includes some new distributions such as new two-parameter-generalized linear exponential distributions. Some statistical properties of the proposed distribution are obtained, such us the hazard rate function, moments, moment generating function and order statistics. We discuss the estimation of the distribution parameters by method of maximum likelihood in both of complete and right censored cases. A modified criteria test is developed to fit this new model when the parameters are unknown and data are right censored. The performances of the methods used are demonstrated by an intensive simulation study whether the usefulness and the versatility in practical applications of this distribution is illustrated by means of real data sets.
DOI: 10.1285/i20705948v16n3p639
title: New Alternative Methods For Estimation Of Asymmetric Stochastic Volatility Model

description: Two methods, the Quasi-likelihood (QL) and Asymptotic Quasi-likelihood (AQL) for finding a point estimate of unknown parameters in asymmetric stochastic volatility (ASV) model with leverage effect are proposed. The QL estimation (QLE) developing if probability distribution of (ASV) model is not available. The AQL estimation (AQLE) building on QLE technique and is obtained where variance and covariance are not available. The AQL estimation substitutes the variance and covariance by kernel estimator in QL. Application of the QLE and AQLE to analyze several data sets modeled by ASV model are considered.
DOI: 10.6084/m9.figshare.25450606
title: Data: Landscape factors can improve the predictive ability of fuel moisture models for assessing wildfire risk

description: Data used in the paper 'Landscape factors can improve the predictive ability of fuel moisture models for assessing wildfire risk'.
DOI: 10.6084/m9.figshare.25450606.v1
title: Data: Landscape factors can improve the predictive ability of fuel moisture models for assessing wildfire risk

description: Data used in the paper 'Landscape factors can improve the predictive ability of fuel moisture models for assessing wildfire risk'.
DOI: 10.1285/i20705948v16n3p654
title: Classical and Bayesian Estimation for 2-Component Mixture of Generalized Rayleigh Distribution based on Type I Censored Samples

description: Mixture models are more appealing and appropriate for studying the heterogeneous nature of lifetimesof certain mechanical, biological, social, economic and several other processes as compared tosimple models. This paper considers mixture of generalized Rayleigh distributions under classical andBayesian perspective based on type I censored samples. The new distribution which exhibits decreasing,decreasing-increasing-decreasing, unimodal and bimodal shaped density while the distribution has theability to model lifetime data with increasing, increasing-decreasing-increasing, bathtub and bi-bathtubshapedfailure rates. We derive some basic and structural properties of the proposed distribution.Moreover, we estimate the parameters of the model by using frequentist and Bayesian approaches. Infrequentist method, the maximum likelihood estimate of the parameters and their asymptotic condenceintervals are obtained while for Bayesian analysis, the squared error loss function (SELF) and uniformas well as beta and gamma priors are considered to obtain the Bayes estimators of the unknown parametersof the model. Furthermore, highest posterior density (HPD) credible intervals are also obtained.In real data analysis, in addition to point estimates of the model parameters, asymptotic condenceintervals and HPD credible intervals, two bootstrap CIs are also provided. Monte Carlo simulationstudy is performed to assess the behavior of these estimators. An application of the model is presentedby re-analyzing strength for single carbon bers data set.
DOI: 10.5281/zenodo.8386678
title: Digitization Workflow for Data Mining in Production Technology applied to a Feed Axis of a CNC Milling Machine

description: Dataset accompanying the publication "Digitization Workflow for Data Mining in Production Technologyapplied to a Feed Axis of a CNC Milling Machine" (https://doi.org/10.1016/j.procs.2024.01.017).
DOI: 10.5281/zenodo.8386679
title: Digitization Workflow for Data Mining in Production Technology applied to a Feed Axis of a CNC Milling Machine

description: Dataset accompanying the publication "Digitization Workflow for Data Mining in Production Technologyapplied to a Feed Axis of a CNC Milling Machine" (https://doi.org/10.1016/j.procs.2024.01.017).
DOI: 10.5519/qd.gr7kg8m8
title: Query on the Natural History Museum Data Portal (data.nhm.ac.uk) (454345 records)
DOI: 10.1285/i20705948v16n3p694
title: On the distribution of the sum of independent exponential-geometric random variables

description: In this article, we derive exact expressions for the probability density function and cumulative distribution function of the sum of independent and non-identical exponential-geometric random variables. Then we discuss the corresponding result for independent and identically distributed exponential-geometric random variables. A saddlepoint approximation is also utilized to approximate the derived distribution. Finally, numerical simulations are used to investigate the precision of the saddlepoint approximation.