cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.9767129
title: Arginine-mediated dissociation of single cells and cell sheets from a polystyrene culture dish

description: Here, we report a novel non-enzymatic cell dissociation method, based on our finding that adherent cells dissociate rapidly from the polystyrene culture dish when incubated in an l- or d-arginine-containing solution. We also demonstrate the successful detachment of confluent NIH/3T3 cell monolayers from the culture dish as a cell sheet by the addition of an arginine solution.
DOI: 10.6084/m9.figshare.9767129.v1
title: Arginine-mediated dissociation of single cells and cell sheets from a polystyrene culture dish

description: Here, we report a novel non-enzymatic cell dissociation method, based on our finding that adherent cells dissociate rapidly from the polystyrene culture dish when incubated in an l- or d-arginine-containing solution. We also demonstrate the successful detachment of confluent NIH/3T3 cell monolayers from the culture dish as a cell sheet by the addition of an arginine solution.
DOI: 10.6084/m9.figshare.9767060
title: The

description: Table S1 was used to generate Figure 1.<br><br>
DOI: 10.6084/m9.figshare.9767078
title: Redescription of the holotype specimen of <i>Chindesaurus bryansmalli</i> Long and Murry, 1995 (Dinosauria, Theropoda), from Petrified Forest National Park, Arizona

description: <i>Chindesaurus bryansmalli</i> is an early dinosaur of uncertain affinities from the Late Triassic Chinle Formation at Petrified Forest National Park, Arizona. Since its first description in 1995, the taxon has been considered a plateosaurid, a non-eusaurischian saurischian, a herrerasaurid, and/or a non-neotheropod member of Theropoda. <i>Chindesaurus bryansmalli</i> is usually scored for about 25% of the characters in a given phylogenetic analysis, and many characters have been scored secondhand from misidentified elements. Here, we provide a redescription of the holotype specimen of <i>C. bryansmalli</i>, correct misidentifications, introduce previously unknown elements, and discuss novel morphological character observations. <i>Chindesaurus bryansmalli</i> is supported as the sister taxon to the non-neotheropod theropod <i>Tawa hallae</i> from the Chinle Formation at Ghost Ranch, New Mexico. The same two most parsimonious trees, with increasing node support, result from iteratively removing the three most incomplete taxa in the employed data set, suggesting that the relationships of stem-averostran theropods are not highly affected by the inclusion of fragmentary specimens. The <i>Chindesaurus</i> + <i>Tawa</i> clade recovered here may represent a potentially diverse group of early theropods prior to the end-Triassic mass extinction.
DOI: 10.6084/m9.figshare.9767078.v1
title: Redescription of the holotype specimen of <i>Chindesaurus bryansmalli</i> Long and Murry, 1995 (Dinosauria, Theropoda), from Petrified Forest National Park, Arizona

description: <i>Chindesaurus bryansmalli</i> is an early dinosaur of uncertain affinities from the Late Triassic Chinle Formation at Petrified Forest National Park, Arizona. Since its first description in 1995, the taxon has been considered a plateosaurid, a non-eusaurischian saurischian, a herrerasaurid, and/or a non-neotheropod member of Theropoda. <i>Chindesaurus bryansmalli</i> is usually scored for about 25% of the characters in a given phylogenetic analysis, and many characters have been scored secondhand from misidentified elements. Here, we provide a redescription of the holotype specimen of <i>C. bryansmalli</i>, correct misidentifications, introduce previously unknown elements, and discuss novel morphological character observations. <i>Chindesaurus bryansmalli</i> is supported as the sister taxon to the non-neotheropod theropod <i>Tawa hallae</i> from the Chinle Formation at Ghost Ranch, New Mexico. The same two most parsimonious trees, with increasing node support, result from iteratively removing the three most incomplete taxa in the employed data set, suggesting that the relationships of stem-averostran theropods are not highly affected by the inclusion of fragmentary specimens. The <i>Chindesaurus</i> + <i>Tawa</i> clade recovered here may represent a potentially diverse group of early theropods prior to the end-Triassic mass extinction.
DOI: 10.6084/m9.figshare.9767057
title: Online experiment of contrast thresholds

description: The dataset of the online experiment of contrast thresholds.
DOI: 10.6084/m9.figshare.9767060.v1
title: The effects of Piper sarmentosum aqueous extracts on zebrafish (Danio rerio) embryos and caudal fin tissue regeneration

description: Table S1 was used to generate Figure 1.Table S2 was used to generate Figure 2.Table S3 was used to generate Figure 3.Table S4 was used to generate Table 3.<br><br>
DOI: 10.6084/m9.figshare.9767060.v2
title: The effects of Piper sarmentosum aqueous extracts on zebrafish (Danio rerio) embryos and caudal fin tissue regeneration

description: Table S1 was used to generate Figure 1.Table S2 was used to generate Figure 2.Table S3 was used to generate Figure 5.Table S4 was used to generate Table 1.<br><br>
DOI: 10.6084/m9.figshare.9766937
title: Supplemental Tables from An assessment of the immune costs associated with meiotic drive elements in <i>Drosophila</i>

description: Supplemental Tables 1-4
DOI: 10.6084/m9.figshare.9766937.v1
title: Supplemental Tables from An assessment of the immune costs associated with meiotic drive elements in <i>Drosophila</i>

description: Supplemental Tables 1-4
DOI: 10.6084/m9.figshare.9766919
title: Metadata record for: PalmTraits 1.0, a species-level functional trait database of palms worldwide

description: This dataset contains key characteristics about the data described in the Data Descriptor PalmTraits 1.0, a species-level functional trait database of palms worldwide. <br> Contents: <br> 1. human readable metadata summary table in CSV format 2. machine readable metadata file in JSON format<br><br>Versioning Note:Version 2 was generated when the metadata format was updated from JSON to JSON-LD. This was an automatic process that changed only the format, not the contents, of the metadata.<br>
DOI: 10.6084/m9.figshare.9767060.v4
title: The

description: Table S1 was used to generate Figure 1.<br><br>
DOI: 10.6084/m9.figshare.9766910
title: Supplementary Material for: Use of Thyroid Hormones in Hypothyroid and Euthyroid Patients; the 2019 Italian Survey

description: <b><i>Background:</i></b> The incidence and prevalence of hypothyroidism are increasing and the threshold for the treatment of hypothyroid as well as individuals without evident thyroid disease with thyroid hormone is declining. <b><i>Objective:</i></b> To investigate endocrinologists’ use of thyroid hormones in hypothyroid and euthyroid patients in Italy, a country where different formulations of levothyroxine (LT4; tablet, liquid solution and soft-gel capsule) are available on the market. <b><i>Methods:</i></b> Members of the Associazione Medici Endocrinologi (Italian Association of Clinical Endocrinologists) were invited to participate in a web-based survey investigating the topic. <b><i>Results:</i></b> A total of 797 of 2,028 (39.3%) members completed all the sections of the survey; 98.7% declared that the treatment of choice for hypothyroidism is LT4. A significant minority (37.3%) indicated that LT4 may be considered in infertile euthyroid women seeking pregnancy and harbouring positive thyroperoxidase antibodies (TPOAb) and in goitre increasing in size (18.1%). LT4 + LT3 was considered by 43.2% for LT4-replaced patients and normal TSH, if they reported persistent symptoms. High percentages of respondents chose LT4 in a liquid solution or soft-gel capsules when taken together with other drugs interfering with LT4 absorption (81.8%), in patients with a history of celiac disease, malabsorption, lactose intolerance, intolerance to common excipients (96.6%), or unexplained poor biochemical control of hypothyroidism (74.4%), or in patients not able to adhere to ingesting LT4 fasted and/or separated from food/drink (98.9%). In total, 43.6% of responders would use LT4 in a liquid solution or soft-gel capsules for hypothyroid patients with biochemical euthyroidism on LT4, who had persistent symptoms. <b><i>Conclusions:</i></b> The preferred treatment for hypothyroidism is LT4; LT3 + LT4 combination treatment is mainly considered in patients with persistent symptoms. A significant minority would offer LT4 to euthyroid women with positive TPOAb and infertility and to euthyroid patients with progressive simple goitre. Alternative LT4 formulations like liquid solution or soft-gel capsules are largely reserved for specific conditions (interfering drugs, actual or suspected malabsorption, inability to take LT4 in the fasting state, unexplained poor biochemical control of hypothyroidism).
DOI: 10.6084/m9.figshare.9767060.v3
title: The effects of Piper sarmentosum aqueous extracts on zebrafish (Danio rerio) embryos and caudal fin tissue regeneration

description: Table S1 was used to generate Figure 1.Table S2 was used to generate Figure 2.Table S3 was used to generate Figure 5.Table S4 was used to generate Table 1.<br><br>
DOI: 10.6084/m9.figshare.9766856
title: Supplementary Material for: Epigenetic Risk Assessment of Female Cancers: Women’s Information Needs and Attitudes

description: <b><i>Background:</i></b> Cancer risk assessment should stratify screening and enable preventive health interventions based on individuals’ risk of developing cancer. Studies are underway to develop epigenetic tests, including trials investigating women’s risk of female-specific cancers. <b><i>Objective:</i></b> Given potential consequences for quality of life and care, women considering such assessment need to be able to make a fully informed choice. It is currently unknown what information they require. <b><i>Method:</i></b> We conducted 4 focus groups with 25 women (aged 30–65 years) to explore what they want to know about epigenetic cancer risk assessment, how they evaluate its usefulness, and how they would like to be informed about their risk. Independent coders categorised paraphrases based on transcribed recordings of the group discussions to enable a summarising text analysis. <b><i>Results:</i></b> The women in the study wanted to understand how the epigenetic approach is different from established genomic tests, how epigenetic changes relate to cancer, and whether the test enables monitoring of one’s cancer risk (<i>n</i> = 11). Furthermore, they desired information about their basic cancer risks (<i>n</i> = 11), about the quality of the assessment (<i>n</i> = 9), and about measures to deal with a risk result (<i>n</i> = 11). <b><i>Conclusions:</i></b> Informed consent in epigenetic cancer risk assessments depends on whether basic cancer risks, uncertainties of testing, and effects of tests on care management are transparently communicated prior to testing. These requirements are not limited to epigenetic testing. Accordingly, physicians and health authorities will have to provide multi-layered information when counselling women on cancer risk assessment.
DOI: 10.6084/m9.figshare.9766910.v1
title: Supplementary Material for: Use of Thyroid Hormones in Hypothyroid and Euthyroid Patients; the 2019 Italian Survey

description: <b><i>Background:</i></b> The incidence and prevalence of hypothyroidism are increasing and the threshold for the treatment of hypothyroid as well as individuals without evident thyroid disease with thyroid hormone is declining. <b><i>Objective:</i></b> To investigate endocrinologists’ use of thyroid hormones in hypothyroid and euthyroid patients in Italy, a country where different formulations of levothyroxine (LT4; tablet, liquid solution and soft-gel capsule) are available on the market. <b><i>Methods:</i></b> Members of the Associazione Medici Endocrinologi (Italian Association of Clinical Endocrinologists) were invited to participate in a web-based survey investigating the topic. <b><i>Results:</i></b> A total of 797 of 2,028 (39.3%) members completed all the sections of the survey; 98.7% declared that the treatment of choice for hypothyroidism is LT4. A significant minority (37.3%) indicated that LT4 may be considered in infertile euthyroid women seeking pregnancy and harbouring positive thyroperoxidase antibodies (TPOAb) and in goitre increasing in size (18.1%). LT4 + LT3 was considered by 43.2% for LT4-replaced patients and normal TSH, if they reported persistent symptoms. High percentages of respondents chose LT4 in a liquid solution or soft-gel capsules when taken together with other drugs interfering with LT4 absorption (81.8%), in patients with a history of celiac disease, malabsorption, lactose intolerance, intolerance to common excipients (96.6%), or unexplained poor biochemical control of hypothyroidism (74.4%), or in patients not able to adhere to ingesting LT4 fasted and/or separated from food/drink (98.9%). In total, 43.6% of responders would use LT4 in a liquid solution or soft-gel capsules for hypothyroid patients with biochemical euthyroidism on LT4, who had persistent symptoms. <b><i>Conclusions:</i></b> The preferred treatment for hypothyroidism is LT4; LT3 + LT4 combination treatment is mainly considered in patients with persistent symptoms. A significant minority would offer LT4 to euthyroid women with positive TPOAb and infertility and to euthyroid patients with progressive simple goitre. Alternative LT4 formulations like liquid solution or soft-gel capsules are largely reserved for specific conditions (interfering drugs, actual or suspected malabsorption, inability to take LT4 in the fasting state, unexplained poor biochemical control of hypothyroidism).
DOI: 10.6084/m9.figshare.9766919.v2
title: Metadata record for: PalmTraits 1.0, a species-level functional trait database of palms worldwide

description: This dataset contains key characteristics about the data described in the Data Descriptor PalmTraits 1.0, a species-level functional trait database of palms worldwide. <br> Contents: <br> 1. human readable metadata summary table in CSV format 2. machine readable metadata file in JSON format<br><br>Versioning Note:Version 2 was generated when the metadata format was updated from JSON to JSON-LD. This was an automatic process that changed only the format, not the contents, of the metadata.<br>
DOI: 10.6084/m9.figshare.9766853
title: Supplementary Material for: Cutaneous T-Cell Acute Lymphoblastic Leukemia and the Expression Pattern of Terminal Deoxynucleotidyl Transferase Immunostaining in Mycosis Fungoides and Spongiotic Dermatitis

description: <b><i>Background/Aims:</i></b> T-cell acute lymphoblastic leukemia (T-ALL) is an uncommon, aggressive malignancy that rarely presents in the skin and is generally not considered as part of the differential diagnosis by dermatologists and dermatopathologists. We describe an unusual case of T-ALL presenting with folliculocentric, erythematous papules on the face, histologically resembling mycosis fungoides (MF). Immunostaining for terminal deoxynucleotidyl transferase (TdT) was positive in tumor cells, supporting the diagnosis of cutaneous involvement by T-ALL. TdT is a nuclear enzyme expressed by immature lymphoid malignancies, but the expression pattern of this marker is not well characterized in the skin. We aimed to assess TdT staining in skin biopsies with similar-appearing lymphocytic infiltrates. <b><i>Methods:</i></b> We evaluated the immunostaining profile of TdT in a cohort of 23 patients, including 13 cases of MF and 10 cases of spongiotic dermatitis. <b><i>Results:</i></b> The lymphocytes in the MF and spongiotic dermatitis cases lacked nuclear staining for TdT. Nonspecific, granular, cytoplasmic staining was observed in a small number of background cells. <b><i>Conclusions:</i></b> TdT may assist dermatopathologists in discriminating malignant infiltrates of T-ALL from other conditions.
DOI: 10.6084/m9.figshare.9766856.v1
title: Supplementary Material for: Epigenetic Risk Assessment of Female Cancers: Women’s Information Needs and Attitudes

description: <b><i>Background:</i></b> Cancer risk assessment should stratify screening and enable preventive health interventions based on individuals’ risk of developing cancer. Studies are underway to develop epigenetic tests, including trials investigating women’s risk of female-specific cancers. <b><i>Objective:</i></b> Given potential consequences for quality of life and care, women considering such assessment need to be able to make a fully informed choice. It is currently unknown what information they require. <b><i>Method:</i></b> We conducted 4 focus groups with 25 women (aged 30–65 years) to explore what they want to know about epigenetic cancer risk assessment, how they evaluate its usefulness, and how they would like to be informed about their risk. Independent coders categorised paraphrases based on transcribed recordings of the group discussions to enable a summarising text analysis. <b><i>Results:</i></b> The women in the study wanted to understand how the epigenetic approach is different from established genomic tests, how epigenetic changes relate to cancer, and whether the test enables monitoring of one’s cancer risk (<i>n</i> = 11). Furthermore, they desired information about their basic cancer risks (<i>n</i> = 11), about the quality of the assessment (<i>n</i> = 9), and about measures to deal with a risk result (<i>n</i> = 11). <b><i>Conclusions:</i></b> Informed consent in epigenetic cancer risk assessments depends on whether basic cancer risks, uncertainties of testing, and effects of tests on care management are transparently communicated prior to testing. These requirements are not limited to epigenetic testing. Accordingly, physicians and health authorities will have to provide multi-layered information when counselling women on cancer risk assessment.
DOI: 10.6084/m9.figshare.9766802
title: Supplementary Material for: Associations between Childhood Disadvantage and Adult Body Mass Index Trajectories: A Follow-Up Study among Midlife Finnish Municipal Employees

description: <b><i>Objective:</i></b> Childhood disadvantage is associated with a higher risk of adult obesity, but little is known about its associations with body mass index (BMI) trajectories during adulthood. This study aimed first to identify adulthood BMI trajectories, and second to investigate how childhood disadvantage is associated with trajectory group membership. <b><i>Methods:</i></b> Data from the Helsinki Health Study, a longitudinal cohort study of initially 40- to 60-year-old employees of the City of Helsinki in Finland, were used. The baseline survey was conducted in 2000–2002, and similar follow-up surveys in 2007, 2012, and 2017. Based on self-reported BMI, participants’ (<i>n =</i>5,266; 83% women) BMI trajectories, including their retrospectively reported BMI at the age of 25 years, were examined. Data on childhood disadvantage, including parental education and 7 types of childhood adversity (their own serious illness; parental divorce, death, mental disorder, or alcohol problems; economic difficulties at home; and peer group bullying) before the age of 16 years, were obtained from the baseline survey. Group-based trajectory modeling was used to identify BMI trajectories, and multinomial logistic regression to analyze the odds for trajectory group membership for the disadvantage variables. <b><i>Results:</i></b> Four ascending BMI trajectories in women and men were found: persistent normal weight (trajectory 1; women 35% and men 25%), normal weight to overweight (trajectory 2; women 41% and men 48%), normal weight to class I obesity (trajectory 3; women 19% and men 23%) and overweight to class II obesity (trajectory 4; women 5% and men 4%). Compared to trajectory 1, women with multiple adversities and repetitive peer bullying in childhood had greater odds of belonging to trajectories 3 and 4, whereas men with parental alcohol problems had greater odds of belonging to trajectory 4. For women and men, a low level of parental education was associated with a higher-level BMI trajectory. <b><i>Conclusions:</i></b> Low parental education for both genders, multiple adversities and repetitive peer bullying in childhood among women, and parental alcohol problems among men increased the odds of developing obesity during adulthood. Further studies are needed to clarify how gender differences modify the effects of childhood disadvantage on adult BMI trajectories.
DOI: 10.6084/m9.figshare.9766847
title: ReadMeCentroids.rtf

description: Metafile
DOI: 10.6084/m9.figshare.9766919.v1
title: Metadata record for: PalmTraits 1.0, a species-level functional trait database of palms worldwide

description: This dataset contains key characteristics about the data described in the Data Descriptor PalmTraits 1.0, a species-level functional trait database of palms worldwide. <br> Contents: <br> 1. human readable metadata summary table in CSV format 2. machine readable metadata file in JSON format
DOI: 10.6084/m9.figshare.9766802.v1
title: Supplementary Material for: Associations between Childhood Disadvantage and Adult Body Mass Index Trajectories: A Follow-Up Study among Midlife Finnish Municipal Employees

description: <b><i>Objective:</i></b> Childhood disadvantage is associated with a higher risk of adult obesity, but little is known about its associations with body mass index (BMI) trajectories during adulthood. This study aimed first to identify adulthood BMI trajectories, and second to investigate how childhood disadvantage is associated with trajectory group membership. <b><i>Methods:</i></b> Data from the Helsinki Health Study, a longitudinal cohort study of initially 40- to 60-year-old employees of the City of Helsinki in Finland, were used. The baseline survey was conducted in 2000–2002, and similar follow-up surveys in 2007, 2012, and 2017. Based on self-reported BMI, participants’ (<i>n =</i>5,266; 83% women) BMI trajectories, including their retrospectively reported BMI at the age of 25 years, were examined. Data on childhood disadvantage, including parental education and 7 types of childhood adversity (their own serious illness; parental divorce, death, mental disorder, or alcohol problems; economic difficulties at home; and peer group bullying) before the age of 16 years, were obtained from the baseline survey. Group-based trajectory modeling was used to identify BMI trajectories, and multinomial logistic regression to analyze the odds for trajectory group membership for the disadvantage variables. <b><i>Results:</i></b> Four ascending BMI trajectories in women and men were found: persistent normal weight (trajectory 1; women 35% and men 25%), normal weight to overweight (trajectory 2; women 41% and men 48%), normal weight to class I obesity (trajectory 3; women 19% and men 23%) and overweight to class II obesity (trajectory 4; women 5% and men 4%). Compared to trajectory 1, women with multiple adversities and repetitive peer bullying in childhood had greater odds of belonging to trajectories 3 and 4, whereas men with parental alcohol problems had greater odds of belonging to trajectory 4. For women and men, a low level of parental education was associated with a higher-level BMI trajectory. <b><i>Conclusions:</i></b> Low parental education for both genders, multiple adversities and repetitive peer bullying in childhood among women, and parental alcohol problems among men increased the odds of developing obesity during adulthood. Further studies are needed to clarify how gender differences modify the effects of childhood disadvantage on adult BMI trajectories.
DOI: 10.6084/m9.figshare.9766847.v1
title: ReadMeCentroids.rtf

description: Metafile
DOI: 10.26180/5d6f5db343e30
title: Low Fluence X-ray projections

description: Low fluence x-ray images for photon counting image processing