DOI: 10.5061/dryad.68ff4
title: Data from: The impact of HCV infection duration on HIV disease progression and response to cART amongst HIV seroconverters in the UK

description: Introduction: The effect of HCV infection on HIV disease progression
 remains unclear; the effect of HCV infection duration on HIV disease
 progression is unknown. Methods: We used data from a cohort of HIV
 seroconverters to investigate the effect of HCV infection duration on time
 from HIV seroconversion to CD4 &lt;350cells/mm3, AIDS or death,
 censoring at the earlier of cART initiation or last clinic visit,
 adjusting for confounders and splitting data into follow up periods from
 HIV seroconversion (&lt;2, 2–4 and &gt;4 years). We additionally
 compared CD4 cell decline following HCV infection to that of mono-infected
 individuals with similar HIV infection duration by fitting a random
 effects model. In a separate analysis, we used linear mixed models to we
 examine the effect of HCV infection and its duration on CD4 increase over
 48 weeks following cART. Results: Of 1655 individuals, 97 (5.9%) were HCV
 co-infected. HCV&lt;1 year was associated with a higher risk of
 endpoint in each follow-up period from HIV seroconversion (HR [95% CI]
 2.58 [1.51, 4.41], p = 0.001; 3.80 [1.20, 12.03], p = 0.023; 2.03 [0.88,
 4.71], p = 0.098 for &lt;2, 2–4 and &gt;4 years respectively),
 compared to mono-infected individuals. However, we found no evidence of an
 association for those with HCV&gt;2 years (all p&gt;0.89).
 Individuals experienced a somewhat greater decrease in CD4 count following
 HCV infection lasting 13 months, relative to individuals with HIV alone,
 (estimate = -3.33, 95% CI [-7.29, 0.63] cells/mm3 per month, p = 0.099).
 Of 1502 initiating cART, 106 (7.1%) were HCV co-infected, with no evidence
 of HCV duration at cART being associated with immunological response (p =
 0.45). Conclusions: The impact of HCV co-infection on HIV disease
 progression appears to be restricted to the first year after HCV
 infection.
description: baseline_characteristics_primary_dryadDataset containing relevant baseline characteristics for those individuals included in the primary analysis investigating time from HIV seroconversion to HIV disease progression.hcv_data_primary_dryadDataset containing all HCV data from those individuals included in the primary analysis investigating time from HIV seroconversion to HIV disease progression.cd4_data_primary_dryadDataset containing all CD4 data from those individuals included in the primary analysis investigating time from HIV seroconversion to HIV disease progression.aids_primary_dryadDataset containing all AIDS data from those individuals included in the primary analysis investigating time from HIV seroconversion to HIV disease progression.deaths_primary_dryadDataset containing all mortality data from those individuals included in the primary analysis investigating time from HIV seroconversion to HIV disease progression.art_primary_dryadDataset containing all ART data from those individuals included in the primary analysis investigating time from HIV seroconversion to HIV disease progression.baseline_characteristics_decline_dryadDataset containing relevant baseline characteristics for those individuals included in the analysis investigating CD4 cell decline following HCV infection.hcv_data_decline_dryadDataset containing all HCV data for those individuals included in the analysis investigating CD4 cell decline following HCV infection.cd4_data_decline_dryadDataset containing all CD4 data from individuals included in the analysis investigating CD4 cell decline following HCV infection.art_decline_dryadDataset containing all ART data from individuals included in the analysis investigating CD4 cell decline following HCV infection.baseline_characteristics_response_dryadDataset containing relevant baseline characteristics for those individuals included in the analysis investigating CD4 response to cART.hcv_data_response_dryadDataset containing all HCV data for those individuals included in the analysis investigating CD4 response to cART.cd4_data_response_dryadDataset containing all CD4 data from individuals included in the analysis investigating CD4 response to cART.art_response_dryadDataset containing all ART data from individuals included in the analysis investigating CD4 response to cART.