cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.17632/j2rnfk6xj8
title: Engineering of pH-dependent antigen binding properties for toxin-targeting IgG1 antibodies using light-chain shuffling

description: Immunoglobulin G (IgG) antibodies that bind their cognate antigen in a pH-dependent manner (acid-switched antibodies) can release their bound antigen for degradation in the acidic environment of endosomes, while the IgGs are rescued by the neonatal Fc receptor (FcRn). Thus, such IgGs can over time neutralize multiple antigens and therefore be used at lower doses than their non-pH-responsive counterparts. Here, we show that light-chain shuffling combined with phage display technology can be used to discover antibodies with increased pH-dependent antigen-binding properties, using the snake toxins, myotoxin II, and α-cobratoxin, as examples. We reveal differences in how the selected IgG1s engage their antigens and human FcRn, and how these translate into distinct cellular handling properties related to their pH-dependent antigen-binding phenotypes and Fc-engineering for improved FcRn binding. Our study showcases the complexity of engineering pH-dependent antigen-binding properties into IgG1s and demonstrates the effects on cellular antibody-antigen recycling.

A data overview can be found in "Data-organization.xlsx"

Provided here are the raw data for each of the figures, as well as protein and nucleotide sequences of:

TPL0039_05_B04

TPL0552_02_A05

TPL0197_01_C08

TPL0544_01_B01
DOI: 10.3535/bz6-y7z-djg
title: Brachiopoda Duméril, 1805

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/xnn-amr-ap0
title: Brachiopoda Duméril, 1805

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/f2f-wrk-8k8
title: Brachiopoda Duméril, 1805

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/gb1-cte-bj8
title: Brachiopoda Duméril, 1805

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.6084/m9.figshare.20418792.v1
title: Positive effects of projected climate change on post-disturbance forest regrowth rates in northeastern North American boreal forests

description: Virtual plots dataset and R codes used to train the random forest model for the paper entitled "<strong>Positive effects of projected climate change on post-disturbance forest regrowth rates in northeastern North American boreal forests</strong>."
DOI: 10.3535/bmf-p15-asz
title: Brachiopoda Duméril, 1805

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/zlz-fr0-42s
title: Brachiopoda Duméril, 1805

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.6084/m9.figshare.20208644.v1
title: Raw data of paper "The Aero Body Righting of Frog Rana Rugulosus Via Hindleg Swings"

description: The .rar file concludes raw data of frog experiments, code for Matlab, and final data for drawing.
DOI: 10.17632/nn3fwy4h4f
title: Digital Nativity and Internet addiction data and extended data

description: The research aimed to explore the relationship between digital nativity and internet addiction among university students at Kwame Nkrumah University of Science and Technology (KNUST) in Ghana. The hypothesis was that higher levels of digital nativity, as measured by the Digital Native Assessment Scale (DNAS), would correlate with higher levels of internet addiction, measured by the Internet Addiction Test (IAT). The data from 411 undergraduate students from various academic disciplines supported this hypothesis, showing a significant positive correlation between DNAS and IAT scores (r = 0.569, p &lt; 0.001). This indicates that students with higher digital nativity are more prone to developing internet addiction behaviours.

Notable findings from the data include the influence of academic level and college affiliation on internet addiction. Students in higher academic years and those from the College of Science exhibited heightened susceptibility to internet addiction. Additionally, the data revealed that both g
DOI: 10.3535/xaj-3mx-7kp
title: Brachiopoda Duméril, 1805

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/82v-97z-4c1
title: Brachiopoda Duméril, 1805

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/ccf-hq4-k56
title: Brachiopoda Duméril, 1805

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/t4p-s0l-40q
title: Brachiopoda Duméril, 1805

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/7dt-lrj-kbw
title: Brachiopoda Duméril, 1805

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/h1k-s4l-kfb
title: Brachiopoda Duméril, 1805

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/adt-gv6-v03
title: Brachiopoda Duméril, 1805

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/f9y-vec-16d
title: Brachiopoda Duméril, 1805

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.17632/975k2wzw3p
title: Data for: Variation of δ18O in precipitation and its response to upstream atmospheric convection and rainout: a case study of Changsha station, south-central China

description: The data set includes stable oxygen isotope in monthly precipitation and corresponding amount and average temperature at Changsha in south-central China during 2010-2017.
DOI: 10.3535/4j2-afa-d7q
title: Brachiopoda Duméril, 1805

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/cj6-866-fyj
title: Brachiopoda Duméril, 1805

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.17632/bgg55b2bjv
title: Data for: Selective uptake of rare earth elements in marine systems as an indication of and control on aerobic bacterial methanotrophy

description: The nucleotide sequence for the large subunit of the xoxF5 gene in Methylomonas sp. LW13 (accession number CP033381.1:4302772-4304619) was used as a query sequence in a discontiguous megablast against the whole genome shotgun project AACY000000000.2, in which the surface waters of the Sargasso Sea were investigated (Venter et al., 2004). This was run in a discontiguous megablast in order to allow for the detection of xoxF genes from other clades (Taubert et al., 2015) besides the expected xoxF5. The first 11 results from this analysis, all of which had a query cover of at least 34% and an E-value below 5e-56, were used as queries in a megablast against the non-redundant nucleotide database (NCBI Resource Coordinators, 2017).
DOI: 10.3535/8wx-5gp-hfd
title: Brachiopoda Duméril, 1805

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/ve9-lj3-jxf
title: Brachiopoda Duméril, 1805

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.17632/tn46tdhc4c
title: Socioeconomic, Ethnocultural, Substance- and Cannabinoid- Related Epidemiology of Down Syndrome USA 1986-2016 Dataset: An Ecological Geotemporospatial and Causal Inference Investigation 

description: Background.  Downs syndrome (DS) is the commonest of the congenital genetic defects.  Its incidence has been rising in recent years for unknown reasons.  Objective.  Investigate the relationship of DS to substance- and cannabinoid- exposure; and causality.

Methods.  Observational ecological population-based epidemiological study 1986-2016.  Analysis performed January 2020.  Geotemporospatial and causal inference analysis.  Participants: Patients were diagnosed with DS and reported to state based registries; collated nationally.  Data source: annual reports of National Birth Defects Prevention Network of Centres for Disease Control.  Exposures: Drug exposure was taken from the National Survey of Drug Use and Health (NSDUH) conducted annually by Substance Abuse and Mental Health Services Administration.  Nationally representative sample 67,000 participants annually.  Drug exposures: cigarette consumption, alcohol abuse, analgesic/opioid abuse, cocaine use and last month cannabis use.  Ethnicity and median household income: US Census Bureau.  Maternal age of childbearing: CDC births registries.  Cannabinoid concentrations: Drug Enforcement Agency seizures.  

Results.  NSDUH report 74.1% mean annual response rate.  All other data was population-wide.  DS rate (DSR) was noted to be rising over time, cannabis use, and cannabis-use quintile.  In the optimal geospatial model lagged to four years terms including Δ9-tetrahydrocannabinol and cannabigerol were significant (from β-est.=4189.96 (95%C.I. 1924.74, 6455.17),  P=2.9x10-4).  Ethnicity, income, and maternal age covariates were not significant.  DSR in states where cannabis was not illegal was higher than elsewhere (β-est.=2.160 (1.5, 2.82), R.R.=1.81 (1.51, 2.16), P=4.7x10-10).  In inverse probability-weighted mixed models terms including cannabinoids were significant (from β-estimate=18.82 (16.82, 20.82), P<0.0001).  EValues in geospatial models ranged up to infinity.

Conclusions.  Our data show that the association between DSR and substance- and cannabinoid- exposure is robust to multivariable geotemporospatial adjustment, implicate particularly cannabigerol and Δ9-tetrahydrocannabinol, and fulfil causal crietria.  Cannabis legalization was associated with elevated DSR’s.  These findings are consistent with those from Hawaii, Colorado, Canada and Australia and concordant with several cellular mechanisms.  Given that the cannabis industry is presently in a rapid growth-commercialization phase the present findings linking cannabis use with megabase scale genotoxicity suggest unrecognized DS risk factors, are of public health importance and suggest that re-focussing the cannabis debate on multigenerational and intergenerational health concerns is prudent.
DOI: 10.3535/bzm-86t-1tq
title: Brachiopoda Duméril, 1805

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/ckd-kxb-65w
title: Specimen from Tallinn University of Technology

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/7y7-d0f-2al
title: †Dicoelosia King, 1850

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/kqq-bnh-hyn
title: †Dicoelosia King, 1850

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/8wr-69w-ymj
title: †Dicoelosia King, 1850

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/dvg-8w5-zsh
title: †Dicoelosia King, 1850

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.17632/4m4frnndyb
title: Data for: Experiments and regular research on the effect of natural fracture size on hydraulic fracture propagation in 3D
DOI: 10.3535/3ke-s00-wms
title: †Dicoelosia King, 1850

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/bh4-4k4-lwh
title: †Dicoelosia King, 1850

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/j25-mvf-z0q
title: †Dalmanellidae Schuchert, 1913

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.15468/dl.syh5fg
title: Occurrence Download

description: A dataset containing 83 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Aegilops triuncialis L., Agrostis gigantea Roth, Ailanthus altissima (Mill.) Swingle, Arundo donax L., Brassica elongata Ehrh., Brassica tournefortii Gouan, Bromus inermis Leyss., Bromus rubens L., Butomus umbellatus L., Centaurea solstitialis L., Cirsium arvense (L.) Scop., Coronilla varia L., Elaeagnus angustifolia L., Erodium cicutarium (L.) L'Hér., Eupatorium cannabinum L., Gleditsia triacanthos L., Hypericum perforatum L., Imperata cylindrica (L.) Raeusch., Lepidium latifolium L., Lotus corniculatus L., Maclura pomifera (Raf. ex Sarg.) C.K.Schneid., Melilotus albus Medik., Onopordum acanthium L., Phalaris arundinacea L., Populus alba L., Tamarix ramosissima Ledeb., Trifolium repens L., Tussilago farfara L., Typha latifolia L., Verbascum thapsus L., Veronica serpyllifolia L.)",
 "BasisOfRecord is one of (Specimen, Human Observation, Observation, Living Specimen, Machine Observation, Literature Occurrence)",
 "Country is one of (Turkmenistan)",
 "HasCoordinate is true",
 "HasGeospatialIssue is false"
 ]
}

 The dataset includes 83 records from 12 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0009537-250325103851331/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.17632/8y4h9y7psr
title:  GFRP 

description: raw data, testing and casting photos, graphs, video, excel and materials tests of the study
DOI: 10.3535/5sm-tsv-496
title: †Dicoelosia King, 1850

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/78t-7g8-4h8
title: †Dicoelosia King, 1850

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.17632/8mzwdr9sxc
title: Quantitative RNA-seq and TMT-MS circadian timecourse data from Neurospora crassa Wild Type and Delta csp-1 genetic backgrounds.

description: Quantitative data on mRNA/protein from A) the raw WT proteome levels, B) the imputed WT proteome levels, C) the eJTK WT proteome scores, D) the raw WT mRNA levels, E) the imputed WT mRNA levels, F) the eJTK WT mRNA scores, G) the raw ∆csp-1 proteome levels, H) the imputed ∆csp-1 proteome levels, I) the eJTK ∆csp-1 proteome scores, J) the setup of the TMT-MS 10-plex analyses.
DOI: 10.3535/gdh-xbk-at0
title: †Dicoelosia King, 1850

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/zl0-jg7-q7f
title: †Dicoelosia King, 1850

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/55c-9xw-q2k
title: †Dicoelosia King, 1850

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/jv2-lxw-edt
title: †Dicoelosia King, 1850

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.6084/m9.figshare.4753507.v1
title: Covert learning in the basal ganglia: raw data

description: Monkeys raw data relative to covert learning in the basal ganglia.
DOI: 10.3535/6gk-0kg-q5s
title: †Dicoelosia King, 1850

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/b0e-1p6-msl
title: †Dicoelosia King, 1850

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/qn4-nn7-rth
title: †Dicoelosia King, 1850

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.17632/b8frhzp3m4
title: NJGRAF — An efficient program for calculation of general recoupling coefficients by graphical analysis, compatible with NJSYM

description: Abstract NJGRAF calculates angular momentum recoupling coefficients by graphical methods. The results are sums of products of 6j coefficients. These can be evaluated several times with different values of the arguments. The number and the range of summation variables are minimal. It is intended to replace NJSYM, with a gain of computer time of up to two orders of magnitude. Title of program: NJGRAF Catalogue Id: ABBY_v1_0 Nature of problem This program calculates a general recoupling coefficient for an arbitrary number of integer or half-integer angular momenta. Versions of this program held in the CPC repository in Mendeley Data ABBY_v1_0; NJGRAF; 10.1016/0010-4655(88)90192-0 This program has been imported from the CPC Program Library held at Queen's University Belfast (1969-2019)
DOI: 10.3535/7b5-gh0-6zb
title: †Dicoelosia King, 1850

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/abm-bay-lr1
title: †Dicoelosia King, 1850

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/2eq-qhc-vpe
title: †Dicoelosia King, 1850

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/cck-2z5-07d
title: †Dicoelosia King, 1850

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.6084/m9.figshare.4205244.v1
title: Jurabrontes curtedulensis virtual tracks generated with DigTrace

description: <b><i>Jurabrontes curtedulensis</i> virtual tracks generated with DigTrace</b><br>Virtual tracks, (point-clouds, .csv) generated with DigTrace Academic (www.digtrace.co.uk) comparing:A: the digitized tracks of the holotype trackway SCR1500-T1 track (7 specimens)B: the holotype and paratypes (4 specimens)<br>The software compares a track population based in the topographical differences among the individual specimens and provided virtual tracks based on statistical comparisons (listed in the file name).1. mean2. median3. max4. min5. standard deviation (std)6. peak-to-peak (ptp)<br>This is a supporting material for http://dx.doi.org/10.1080/08912963.2017.1324438<br><b>Citation for this article</b>: Marty D., Belvedere M., Razzolini N.L., Lockley M.G., Paratte G., Cattin M., Lovis C. and Meyer C.A. 2017. The tracks of giant theropods (<i>Jurabrontes curtedulensis</i> ichnogen. & ichnosp. nov.) from the Late Jurassic of NW Switzerland: palaeoecological and palaeogeographical implications. Historical Biology. doi: 10.1080/08912963.2017.1324438<br><br>
DOI: 10.3535/cm6-rg0-tam
title: †Dicoelosia King, 1850

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/hf0-3nn-d0p
title: †Dicoelosia King, 1850

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/qly-cqq-d8k
title: †Dicoelosia King, 1850

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/tkr-c3a-fv9
title: †Dicoelosia King, 1850

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/azl-3r2-cgh
title: †Dicoelosia King, 1850

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/rw2-ycp-jjn
title: †Dicoelosia King, 1850

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/zjc-xdd-md0
title: †Dicoelosia King, 1850

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.6084/m9.figshare.26643547.v1
title: Additional file 7 of Integrating compositional and functional content to describe vaginal microbiomes in health and disease

description: Additional file 7: Table S2. Associations between race, age, Nugent score, and Amsel-BV and metagenomic community state types (mgCSTs). Mantel-Haen (MH) or Chi-Squared (Chi-sq) tests evaluated significant deviations from study-wide proportions.
DOI: 10.3535/831-5p5-sk8
title: †Dicoelosia King, 1850

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/x4q-b3x-h4d
title: †Dicoelosia King, 1850

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/yzs-2fb-0bl
title: †Dicoelosia King, 1850

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/7p5-m9x-ygk
title: †Dicoelosia King, 1850

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/mc3-k1m-efz
title: †Dicoelosia King, 1850

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/a61-3ry-f1f
title: †Dicoelosia King, 1850

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/5tx-7c2-sl7
title: †Dicoelosia King, 1850

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/ypv-2ke-hkd
title: †Dicoelosia King, 1850

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.15468/dl.hnx5qk
title: Occurrence Download

description: A dataset containing 1280 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Gastrimargus marmoratus (Thunberg, 1815)"
 ]
}

 The dataset includes 1280 records from 62 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0009538-250325103851331/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.3535/4sf-rpp-4av
title: †Dicoelosia King, 1850

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/w3a-wwh-ls3
title: †Dicoelosia King, 1850

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.17632/rdv35w5xcz
title: Data for: ‘You are where you shop’: Examining stereotypes about town center shoppers

description: Data set for the article entitled: ‘You are where you shop’: Examining stereotypes about town center shoppers. Please contact burak.tunca@fek.lu.se or burtunca@gmail.com for more information.
DOI: 10.3535/lp6-cxh-9ld
title: †Dicoelosia King, 1850

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/v9f-bz3-gx2
title: †Dicoelosia King, 1850

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/egw-efj-alv
title: †Dicoelosia King, 1850

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/z8e-e2a-1xx
title: †Dicoelosia King, 1850

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/0c0-x6x-xq7
title: †Dicoelosia King, 1850

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/7sc-mlg-v3w
title: †Dicoelosia King, 1850

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/99x-wvr-9j2
title: †Dicoelosia King, 1850

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/j22-d39-yam
title: †Dicoelosia King, 1850

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.6084/m9.figshare.c.3493548_d41.v1
title: Sample image 1: long-term single-cell growth monitoring (MC4100 cells at 37C).jpg

description: Sample image of cells cultured at 37C
DOI: 10.3535/0dr-60c-e6b
title: †Dicoelosia King, 1850

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/sjn-trl-7xa
title: †Dicoelosia King, 1850

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/7z4-wcw-qzx
title: †Dicoelosia King, 1850

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.