cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.21907533.v1
title: Application of capillary zone electrophoresis to determine second-generation H1 antihistaminic drugs, loratadine and rupatadine

description: Abstract The second generation of H1 antihistamines from the piperidine group are often used for treating allergic diseases due to their action on histaminic receptors, the primary mediator of allergy. Moreover, the antihistamines have anti-inflammatory action, mediated through platelet-activating factor blocking activity. A simple and rapid capillary zone electrophoresis method was developed and validated for the determination of loratadine (LOR) and rupatadine (RUP) in tablets. The analyses were carried out using a fused silica capillary of 50.2 cm (40 cm effective length), 75 µm i.d. The background electrolyte was composed of boric acid 35 mmol/L, pH 2.5. Voltage of 20 kV, hydrodynamic injection of 3447.3 Pa for 3s, temperature at 25 ºC, and UV detection at 205 nm were applied. Electrophoretic separation was achieved at 1.8 and 2.8 min for RUP and LOR, respectively. The method was linear for both drugs in a range of 50.0 to 400.0 μg/mL (r&gt;0.99). The limits of detection and quantification were 46.37 and 140.52 μg/mL, for LOR and 29.60 and 89.69 μg/mL for RUP respectively. The precision was less than 5.0 % for both drugs. The average recovery was approximately 100 %. The proposed novel method can significantly contribute to the rapid detection of counterfeit products and in quality control of drug products containing antihistamines.
DOI: 10.6084/m9.figshare.21907536
title: The Role of Critical Care Pharmacists Beyond Intensive Care Units: A Narrative Review on Medication Management for ICU Survivors

description: Abstract There is a global improvement in critical care services that leads to prolonged survival after ICU stay. This improvement has increased the demand for multidisciplinary critical care services beyond the ICU. Recently, efforts focused on the patient’s quality of life after ICU discharge and family involvement in their care. Most older adults who survive an ICU stay are challenged by complex medication changes following discharge, as are their caregivers. Limited literature addresses the standard of practice for medication management and critical care pharmacists’ involvement in post-ICU services. This narrative review describes the available literature that addresses medication management in post-ICU settings by critical care pharmacists and potential axes for future research. The included articles were articles published in English related to adult ICU survivors and addressed pharmacist involvement or medication management. The main findings summarize the most performed pharmacist services following ICU discharge, including medication reconciliation, full medication review, and adverse drug event preventative measures. This review concluded a lack of consensus about the standard model of post-ICU pharmacy services and the relationship of these services with long-term outcomes.
DOI: 10.6084/m9.figshare.21907536.v1
title: The Role of Critical Care Pharmacists Beyond Intensive Care Units: A Narrative Review on Medication Management for ICU Survivors

description: Abstract There is a global improvement in critical care services that leads to prolonged survival after ICU stay. This improvement has increased the demand for multidisciplinary critical care services beyond the ICU. Recently, efforts focused on the patient’s quality of life after ICU discharge and family involvement in their care. Most older adults who survive an ICU stay are challenged by complex medication changes following discharge, as are their caregivers. Limited literature addresses the standard of practice for medication management and critical care pharmacists’ involvement in post-ICU services. This narrative review describes the available literature that addresses medication management in post-ICU settings by critical care pharmacists and potential axes for future research. The included articles were articles published in English related to adult ICU survivors and addressed pharmacist involvement or medication management. The main findings summarize the most performed pharmacist services following ICU discharge, including medication reconciliation, full medication review, and adverse drug event preventative measures. This review concluded a lack of consensus about the standard model of post-ICU pharmacy services and the relationship of these services with long-term outcomes.
DOI: 10.6084/m9.figshare.21907542
title: Preliminary prospection of phytotherapic compounds from the essential oils from barks and leaves of Umburana (Commiphora Leptophloeos)

description: Abstract The potential of the biome caatinga (exclusive from northeastern Brazil) has been evaluated in recent research for application in the pharmaceutical industry. Among the species of medicinal plants from caatinga, one can highlight the Commiphora leptophloeos (umburana), which has been used as infusions and syrups by the regional population for inflammatory and infectious diseases. Essential oils from umburana leaves and barks were obtained in a Clevenger apparatus and analyzed by gas chromatography/mass spectrometry, and total phenolic and flavonoids were determined by spectrophotometric analysis. It was observed that a large part of the major compounds present in the essential oil is described as having antitumor activity, enabling research in investigational oncology with umburana (C. leptophloeos). In addition, some little explored components have been identified, such as cadinene, alpha-selinene, and elemenone. Despite being easily found in several plants, there are no clinical trials involving their biological activity in a well-defined isolated form, which could make exploring new studies possible. Furthermore, the presence of phenolic compounds and flavonoids allows future studies about the potential antimicrobial and antioxidant activity.
DOI: 10.6084/m9.figshare.21907542.v1
title: Preliminary prospection of phytotherapic compounds from the essential oils from barks and leaves of Umburana (Commiphora Leptophloeos)

description: Abstract The potential of the biome caatinga (exclusive from northeastern Brazil) has been evaluated in recent research for application in the pharmaceutical industry. Among the species of medicinal plants from caatinga, one can highlight the Commiphora leptophloeos (umburana), which has been used as infusions and syrups by the regional population for inflammatory and infectious diseases. Essential oils from umburana leaves and barks were obtained in a Clevenger apparatus and analyzed by gas chromatography/mass spectrometry, and total phenolic and flavonoids were determined by spectrophotometric analysis. It was observed that a large part of the major compounds present in the essential oil is described as having antitumor activity, enabling research in investigational oncology with umburana (C. leptophloeos). In addition, some little explored components have been identified, such as cadinene, alpha-selinene, and elemenone. Despite being easily found in several plants, there are no clinical trials involving their biological activity in a well-defined isolated form, which could make exploring new studies possible. Furthermore, the presence of phenolic compounds and flavonoids allows future studies about the potential antimicrobial and antioxidant activity.
DOI: 10.6084/m9.figshare.21907548
title: Growth parameters of backcross-derived Elaeis oleifera (Kunth) Cortés from Taisha - Ecuador and their potential for plant breeding in oil palm

description: ABSTRACT The palm Elaeis oleifera from Taisha was first described in 1986, but remains a valuable genetic resource to be evaluated, as it may be important for obtaining high-yielding hybrid genotypes and good-quality oil. This research aimed to determine the attributes of Elaeis oleifera (O) Taisha, E. guineensis Jacq. (G), their hybrids (O × G) and backcrosses [(O × G) × G = Bc], regarding leaf, stipe and pollen parameters, to expand the potential knowledge toward the obtention of interspecific hybrids that improve the crop competitiveness and sustainability. Contrasts were shown between both genotypes. E. oleifera showed a foliar emission of 1.67 leaves per month, when compared to a mean value of 2.37 leaves per month for O × G, Bc and E. guineensis. The leaf area of the leaf number 17 was 5.55 m2 for E. oleifera and 8.50 m2 in the other materials. Additionally, E. oleifera reached a shorter height and lower number of leaflets for the leaf 17 and stipe growth, in comparison to the other genotypes that showed vegetative hybrid vigor. Regarding pollen germination, E. oleifera and E. guineensis showed high percentages, whereas the hybrids obtained 14.26 % and Bc 62.47 %. Therefore, the introgression of genes from E. oleifera to E. guineensis for slow growth and smaller foliar area and from backcrosses for high pollen germination can be useful for selecting and obtaining high-yield improved hybrids and short and compact palms.
DOI: 10.6084/m9.figshare.21907548.v1
title: Growth parameters of backcross-derived Elaeis oleifera (Kunth) Cortés from Taisha - Ecuador and their potential for plant breeding in oil palm

description: ABSTRACT The palm Elaeis oleifera from Taisha was first described in 1986, but remains a valuable genetic resource to be evaluated, as it may be important for obtaining high-yielding hybrid genotypes and good-quality oil. This research aimed to determine the attributes of Elaeis oleifera (O) Taisha, E. guineensis Jacq. (G), their hybrids (O × G) and backcrosses [(O × G) × G = Bc], regarding leaf, stipe and pollen parameters, to expand the potential knowledge toward the obtention of interspecific hybrids that improve the crop competitiveness and sustainability. Contrasts were shown between both genotypes. E. oleifera showed a foliar emission of 1.67 leaves per month, when compared to a mean value of 2.37 leaves per month for O × G, Bc and E. guineensis. The leaf area of the leaf number 17 was 5.55 m2 for E. oleifera and 8.50 m2 in the other materials. Additionally, E. oleifera reached a shorter height and lower number of leaflets for the leaf 17 and stipe growth, in comparison to the other genotypes that showed vegetative hybrid vigor. Regarding pollen germination, E. oleifera and E. guineensis showed high percentages, whereas the hybrids obtained 14.26 % and Bc 62.47 %. Therefore, the introgression of genes from E. oleifera to E. guineensis for slow growth and smaller foliar area and from backcrosses for high pollen germination can be useful for selecting and obtaining high-yield improved hybrids and short and compact palms.
DOI: 10.6084/m9.figshare.21907549
title: Carnauba bagana substrate and application of humic substances on the production of yellow passion fruit seedlings

description: ABSTRACT Owing to the high prices of agricultural inputs, it is necessary to seek alternatives that minimize costs during the seedling production stage, such as the use of agro-industrial residues to formulate substrates and the application of humic substances to increase the availability of nutrients. This study aimed to evaluate the production of yellow passion fruit seedlings in substrates based on carnauba bagana under increasing doses of humic substances. The design was completely randomized, in a 3 x 4 factorial scheme, referring to three substrates formulated with carnauba bagana (0, 50 and 100 %) plus soil and four doses of humic substances (0, 12.5, 25 and 50 g L-1). The use of carnauba bagana in the substrate increased the leaf area, plant height, stem diameter, root length, root volume, shoot and root dry mass, and improved the seedlings quality. The application of humic substances to the substrate did not stimulate the seedlings development.
DOI: 10.6084/m9.figshare.21907549.v1
title: Carnauba bagana substrate and application of humic substances on the production of yellow passion fruit seedlings

description: ABSTRACT Owing to the high prices of agricultural inputs, it is necessary to seek alternatives that minimize costs during the seedling production stage, such as the use of agro-industrial residues to formulate substrates and the application of humic substances to increase the availability of nutrients. This study aimed to evaluate the production of yellow passion fruit seedlings in substrates based on carnauba bagana under increasing doses of humic substances. The design was completely randomized, in a 3 x 4 factorial scheme, referring to three substrates formulated with carnauba bagana (0, 50 and 100 %) plus soil and four doses of humic substances (0, 12.5, 25 and 50 g L-1). The use of carnauba bagana in the substrate increased the leaf area, plant height, stem diameter, root length, root volume, shoot and root dry mass, and improved the seedlings quality. The application of humic substances to the substrate did not stimulate the seedlings development.
DOI: 10.6084/m9.figshare.21907551
title: Effects of vestibular rehabilitation in the management of patients with and without vestibular migraine

description: Abstract Objective: Vestibular Migraine (VM) is the second most common cause in patients with vertigo. Patients with VM complain about vestibular symptoms during a headache attack or during the period between attacks. Vestibular Rehabilitation (VR), an exercised based therapy to treat dizziness and balance dysfunction has been shown to be effective in vestibular diseases. In this study, we aimed to assess the effect of VR for vestibular symptoms and quality of life in VM patients, and to compare the results with patients with vestibular disorders without migraine. Methods: Sixty (60) patients who received VR treatment were divided into two groups: vestibular migraine group (30 patients) and non-migraine vestibular dysfunction group (30 patients). All patients received VR for 18 sessions and the program was completed in 1.5 months. Preand post-treatment Dizziness Handicap Inventory (DHI) scores, Vestibular Disorders Activities of Daily Living Scale (VADL) scores, the frequency of dizziness and headache, and Computerized Dynamic Posturography (CDP) scores were assessed and compared retrospectively. Results: With VR in both the vestibular migraine group and vestibular dysfunction group, DHI score, VADL score, the frequency of dizziness and headache scores significantly impaired. Post-treatment CDP results were higher than pre- treatment results for both patient groups. Conclusion: With VR, a significant improvement was observed in subjective and objective balance assessment measurement. Vestibular Rehabilitation must be considered in patients who do not benefit from medical therapy or have limited benefit. Level of evidence: Level III (evidence obtained from well-designed controlled trials without randomization).
DOI: 10.6084/m9.figshare.21907551.v1
title: Effects of vestibular rehabilitation in the management of patients with and without vestibular migraine

description: Abstract Objective: Vestibular Migraine (VM) is the second most common cause in patients with vertigo. Patients with VM complain about vestibular symptoms during a headache attack or during the period between attacks. Vestibular Rehabilitation (VR), an exercised based therapy to treat dizziness and balance dysfunction has been shown to be effective in vestibular diseases. In this study, we aimed to assess the effect of VR for vestibular symptoms and quality of life in VM patients, and to compare the results with patients with vestibular disorders without migraine. Methods: Sixty (60) patients who received VR treatment were divided into two groups: vestibular migraine group (30 patients) and non-migraine vestibular dysfunction group (30 patients). All patients received VR for 18 sessions and the program was completed in 1.5 months. Preand post-treatment Dizziness Handicap Inventory (DHI) scores, Vestibular Disorders Activities of Daily Living Scale (VADL) scores, the frequency of dizziness and headache, and Computerized Dynamic Posturography (CDP) scores were assessed and compared retrospectively. Results: With VR in both the vestibular migraine group and vestibular dysfunction group, DHI score, VADL score, the frequency of dizziness and headache scores significantly impaired. Post-treatment CDP results were higher than pre- treatment results for both patient groups. Conclusion: With VR, a significant improvement was observed in subjective and objective balance assessment measurement. Vestibular Rehabilitation must be considered in patients who do not benefit from medical therapy or have limited benefit. Level of evidence: Level III (evidence obtained from well-designed controlled trials without randomization).
DOI: 10.6084/m9.figshare.21907554
title: Accident and social security benefits granted to cancer patients in Brazil, 2008-2014

description: Abstract This article aims to describe the distribution of cancer among the benefits granted by the General Social Security Registry, from 2008 to 2014, in Brazil. Ecological study using data given by the National Social Security Institute. The proportion of accidental (work-related) and social security (general) benefits granted by cancer in Brazil was determined, among the benefits granted for all causes, and a spatial analysis was conducted to assess the geographical distribution of these proportions, with the states Brazilians as a unit of analysis. Cancer was the reason for granting 533,438 benefits (2.9% of the total benefits granted for all causes), with a predominance of females in social security benefits (53.7%) and males in accidental benefits (71.6 %). The highest proportions of social security benefits for cancer occurred in North and Midwest regions. In 19 of the 26 Brazilian states (including all states in the southern region) and in the Federal District, there was no granting of accident benefits for cancer. The analysis of the occurrences of cancer that generated benefit concessions suggests a disproportionality in granting of social security benefits in relation to accident workers, mainly in North, Northeast and South regions of Brazil.
DOI: 10.6084/m9.figshare.21907554.v1
title: Accident and social security benefits granted to cancer patients in Brazil, 2008-2014

description: Abstract This article aims to describe the distribution of cancer among the benefits granted by the General Social Security Registry, from 2008 to 2014, in Brazil. Ecological study using data given by the National Social Security Institute. The proportion of accidental (work-related) and social security (general) benefits granted by cancer in Brazil was determined, among the benefits granted for all causes, and a spatial analysis was conducted to assess the geographical distribution of these proportions, with the states Brazilians as a unit of analysis. Cancer was the reason for granting 533,438 benefits (2.9% of the total benefits granted for all causes), with a predominance of females in social security benefits (53.7%) and males in accidental benefits (71.6 %). The highest proportions of social security benefits for cancer occurred in North and Midwest regions. In 19 of the 26 Brazilian states (including all states in the southern region) and in the Federal District, there was no granting of accident benefits for cancer. The analysis of the occurrences of cancer that generated benefit concessions suggests a disproportionality in granting of social security benefits in relation to accident workers, mainly in North, Northeast and South regions of Brazil.
DOI: 10.6084/m9.figshare.21856083
title: Ultrafine quartz flocculation: Part II. Main variables

description: Abstract Flocculation is a complex process, usually dependant on various conditions to perform adequately. Nevertheless, the relevance and interaction of the process variables are not easily found in literature. In this study, nine variables of ultrafine quartz flocculation systems, defined in Part 1 of this study, were analysed. The effects of each variable and their interactions in the system were investigated based on flocculation and sedimentation tests. The results were statistically evaluated using the supernatant turbidity as experimental response. The evaluations resulting from the statistical approach indicated that suspension pH (5.49%) was the most significant variable, followed by flocculant concentration (4.07%) with the second greatest effect on the turbidity of the supernatant. Solid concentration, agitation intensity, and surfactant conditioning time (4.05%, 3.51% and 3.51%, respectively), also have significant effects on ultrafine quartz flocculation. The flocculant concentration and the surfactant conditioning time were the variables with the most significant interactions with the main variables. The Camp Number values showed a negative exponential relationship with the turbidity results, proving to be an important tool to evaluate flocculation. Backscattered electron scanning microscopy images of flocs formed in the presence of 30 g/t PAM showed compact flocs in the size range between 150 and 365 µm, with noticeable sphericity.
DOI: 10.6084/m9.figshare.21856083.v1
title: Ultrafine quartz flocculation: Part II. Main variables

description: Abstract Flocculation is a complex process, usually dependant on various conditions to perform adequately. Nevertheless, the relevance and interaction of the process variables are not easily found in literature. In this study, nine variables of ultrafine quartz flocculation systems, defined in Part 1 of this study, were analysed. The effects of each variable and their interactions in the system were investigated based on flocculation and sedimentation tests. The results were statistically evaluated using the supernatant turbidity as experimental response. The evaluations resulting from the statistical approach indicated that suspension pH (5.49%) was the most significant variable, followed by flocculant concentration (4.07%) with the second greatest effect on the turbidity of the supernatant. Solid concentration, agitation intensity, and surfactant conditioning time (4.05%, 3.51% and 3.51%, respectively), also have significant effects on ultrafine quartz flocculation. The flocculant concentration and the surfactant conditioning time were the variables with the most significant interactions with the main variables. The Camp Number values showed a negative exponential relationship with the turbidity results, proving to be an important tool to evaluate flocculation. Backscattered electron scanning microscopy images of flocs formed in the presence of 30 g/t PAM showed compact flocs in the size range between 150 and 365 µm, with noticeable sphericity.
DOI: 10.6084/m9.figshare.21856314
title: Numerical and theoretical investigation of bolted sleeve connections with rectangular hollow sections

description: Abstract This article presents a theoretical and numerical study of bolted sleeve connections with rectangular hollow sections (RHS) under axial tension and compression. The geometric form of a hollow section provides resistance for high axial loads, torsion and combines effects, spreading its utilization in truss systems. In this context, the sleeve connections proposed explore these characteristics of RHS and offer an attractive aesthetic appearance for the continuity of elements. The bolted sleeve connection with RHS is formed by two outer tubes connected by an inner tube and staggered bolts. Herein, a parametric study was developed for identification of the failure modes in the connection. Finite element models with different geometric parameters and number of bolts were created in commercial software. The width, depth and thickness of RHS tubes and diameter of bolts were variated. In the theoretical/numerical/parametric results, the yielding gross section failure, the fracture through the effective net area failure and the bearing failure were observed. These failure modes occurred in both outer and inner tubes. The load results were compared to determine the resistance capacity of sleeve connections. The theoretical formulations were evaluated for representation of the ultimate load of the failure modes.