cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.15131/shef.data.9735278
title: Dataset for "Direct Antenna Modulation for high-order Phase Shift Keying" in IEEE Transactions on Antennas and Propagation

description: This is the dataset for journal paper "Direct Antenna Modulation for high-order Phase Shift Keying" as published in IEEE Transactions on Antennas and Propagation (DOI: 10.1109/TAP.2019.2935136 ) It contains the data for various figures presented in the paper. The methodology for each part of the dataset is detailed in the paper, and how each file relates to the figures in the paper is set out in the readme file.<br>
DOI: 10.6084/m9.figshare.9735302.v1
title: Supplementary Material for: MCH Neuron Activity Is Sufficient for Reward and Reinforces Feeding

description: <b><i>Background:</i></b> Melanin-concentrating hormone (MCH)-expressing neurons have been implicated in regulation of energy homeostasis and reward, yet the role of their electrical activity in short-term appetite and reward modulation has not been fully understood. <b><i>Objectives:</i></b> We investigated short-term behavioral and physiological effects of MCH neuron activity manipulations. <b><i>Methods:</i></b> We used optogenetic and chemogenetic approaches in <i>Pmch-cre</i> transgenic mice to acutely stimulate/inhibit MCH neuronal activity while probing feeding, locomotor activity, anxiety-like behaviors, glucose homeostasis, and reward. <b><i>Results:</i></b> MCH neuron activity is neither required nor sufficient for short-term appetite unless stimulation is temporally paired with consumption. MCH neuronal activation does not affect short-term locomotor activity, but inhibition improves glucose tolerance and is mildly anxiolytic. Finally, using two different operant tasks, we showed that activation of MCH neurons alone is sufficient to induce reward. <b><i>Conclusions:</i></b> Our results confirm diverse behavioral/physiological functions of MCH neurons and suggest a direct role in reward function.
DOI: 10.6084/m9.figshare.9735224
title: Six new epibiotic <i>Proschkinia</i> (Bacillariophyta) species and new insights into the genus phylogeny

description: The diatom genus <i>Proschkinia</i> is a common element of biofilms covering diverse substrata in saline inland or shallow coastal environments. It can be distinguished from other naviculoid taxa by its lanceolate valves with a fistula located within the central area and numerous open girdle bands with a U-shaped cross-section and a single row of perforations on the internal side of the fold. Despite this distinct morphology, frustules of <i>Proschkinia</i> are typically weakly silicified and often overlooked when cleaned diatom material is analysed. The current paper describes six new species of <i>Proschkinia</i>: <i>P. browderiana</i> sp. nov., <i>P. lacrimula</i> sp. nov., <i>P. maluszekiana</i> sp. nov., <i>P. sulcata</i> sp. nov., <i>P. torquata</i> sp. nov. and <i>P. vergostriata</i> sp. nov., found in numerous samples of marine organisms, such as sea turtles (including sea turtle museum specimens), sea turtle-associated barnacles and seagrass from across the three oceans. Some of the newly described taxa were found on multiple individuals belonging to different sea turtle species, whereas others were in samples collected from different continents. Molecular phylogenetic analysis indicated that examined <i>Proschkinia</i> strains formed a monophyletic clade, sister to <i>Fistulifera</i>.
DOI: 10.6084/m9.figshare.9735233
title: Data.xlsx

description: 目标大小，二维目标和运动角等附加难度因素对预测时间的影响
DOI: 10.6084/m9.figshare.9735224.v1
title: Six new epibiotic <i>Proschkinia</i> (Bacillariophyta) species and new insights into the genus phylogeny

description: The diatom genus <i>Proschkinia</i> is a common element of biofilms covering diverse substrata in saline inland or shallow coastal environments. It can be distinguished from other naviculoid taxa by its lanceolate valves with a fistula located within the central area and numerous open girdle bands with a U-shaped cross-section and a single row of perforations on the internal side of the fold. Despite this distinct morphology, frustules of <i>Proschkinia</i> are typically weakly silicified and often overlooked when cleaned diatom material is analysed. The current paper describes six new species of <i>Proschkinia</i>: <i>P. browderiana</i> sp. nov., <i>P. lacrimula</i> sp. nov., <i>P. maluszekiana</i> sp. nov., <i>P. sulcata</i> sp. nov., <i>P. torquata</i> sp. nov. and <i>P. vergostriata</i> sp. nov., found in numerous samples of marine organisms, such as sea turtles (including sea turtle museum specimens), sea turtle-associated barnacles and seagrass from across the three oceans. Some of the newly described taxa were found on multiple individuals belonging to different sea turtle species, whereas others were in samples collected from different continents. Molecular phylogenetic analysis indicated that examined <i>Proschkinia</i> strains formed a monophyletic clade, sister to <i>Fistulifera</i>.
DOI: 10.6084/m9.figshare.9735233.v1
title: Data.xlsx

description: 目标大小，二维目标和运动角等附加难度因素对预测时间的影响
DOI: 10.6084/m9.figshare.9735053
title: Wild bumble bees (Hymenoptera: Apidae: Bombini) as a potential reservoir for bee pathogens in northeastern Argentina

description: The genus <i>Bombus</i> is represented by 38 subgenera around the world with nearly 250 described species. They are among the most efficient insect pollinators and therefore important to the ecology and the economy. In Argentina, this genus it is represented by eight native and two introduced species. Several bee pathogens related to colony losses have been found in wild pollinators around the world, including bumble bees. We studied the presence of these pathogens in bumble bee species from different locations in northeastern Argentina to determine their relationship with prevalent bee pathogens previously detected in the country. We collected 93 specimens of three bumble bee species and screened them for eleven honey bee pathogens. We detected <i>Nosema ceranae</i>, <i>Ascosphaera apis</i>, <i>Melisococcus plutonius</i>, and four viruses. Sixteen samples were pathogen-free and 77 samples contained one or more pathogens. If bumble bees are a potential reservoir for bee pathogens, this could lead to the development of Emerging Infection Diseases in wild bees. However, further studies are required to confirm this assumption and to determine the direction of the spillover between wild and managed bees.
DOI: 10.6084/m9.figshare.9735038
title: Supplementary Material for: Neuroinflammation and B-Cell Phenotypes in Cervical and Lumbosacral Regions of the Spinal Cord in Experimental Autoimmune Encephalomyelitis in the Absence of Pertussis Toxin

description: <b><i>Objectives:</i></b> The active experimental autoimmune encephalomyelitis (EAE) model is often initiated using myelin oligodendrocyte glycoprotein (MOG) immunization followed by pertussis toxin (PTX) to study multiple sclerosis. However, PTX inactivates G protein-coupled receptors, and with increasing knowledge of the role that various G protein-coupled receptors play in immune homeostasis, it is valuable to establish neuroimmune endpoints for active EAE without PTX. <b><i>Methods:</i></b> Female C57BL/6 mice were immunized with MOG<sub>35–55</sub> peptide in Complete Freund’s Adjuvant and neuroinflammation, including central nervous system B-cell infiltration, was compared to saline-injected mice. Since it was anticipated that disease onset would be slower and less robust than EAE in the presence of PTX, both cervical and lumbosacral sections of the spinal cord were evaluated. <b><i>Results:</i></b> Immunohistochemical analysis showed that EAE without PTX induced immune infiltration, CCL2 and VCAM-1 upregulation. Demyelination in the cervical region correlated with the infiltration of CD19<sup>+</sup> B cells in the cervical region. There was upregulation of IgG, CD38, and PDL1 on B cells in cervical and lumbosacral regions of the spinal cord in EAE without PTX. Interestingly, IgG was expressed predominantly by CD19<sup>–</sup> cells. <b><i>Conclusions:</i></b> These data demonstrate that many neuroimmune endpoints are induced in EAE without PTX and although clinical disease is mild, this can be used as an autoimmune model when PTX inactivation of G protein-coupled receptors is not desired.
DOI: 10.6084/m9.figshare.9735038.v1
title: Supplementary Material for: Neuroinflammation and B-Cell Phenotypes in Cervical and Lumbosacral Regions of the Spinal Cord in Experimental Autoimmune Encephalomyelitis in the Absence of Pertussis Toxin

description: <b><i>Objectives:</i></b> The active experimental autoimmune encephalomyelitis (EAE) model is often initiated using myelin oligodendrocyte glycoprotein (MOG) immunization followed by pertussis toxin (PTX) to study multiple sclerosis. However, PTX inactivates G protein-coupled receptors, and with increasing knowledge of the role that various G protein-coupled receptors play in immune homeostasis, it is valuable to establish neuroimmune endpoints for active EAE without PTX. <b><i>Methods:</i></b> Female C57BL/6 mice were immunized with MOG<sub>35–55</sub> peptide in Complete Freund’s Adjuvant and neuroinflammation, including central nervous system B-cell infiltration, was compared to saline-injected mice. Since it was anticipated that disease onset would be slower and less robust than EAE in the presence of PTX, both cervical and lumbosacral sections of the spinal cord were evaluated. <b><i>Results:</i></b> Immunohistochemical analysis showed that EAE without PTX induced immune infiltration, CCL2 and VCAM-1 upregulation. Demyelination in the cervical region correlated with the infiltration of CD19<sup>+</sup> B cells in the cervical region. There was upregulation of IgG, CD38, and PDL1 on B cells in cervical and lumbosacral regions of the spinal cord in EAE without PTX. Interestingly, IgG was expressed predominantly by CD19<sup>–</sup> cells. <b><i>Conclusions:</i></b> These data demonstrate that many neuroimmune endpoints are induced in EAE without PTX and although clinical disease is mild, this can be used as an autoimmune model when PTX inactivation of G protein-coupled receptors is not desired.
DOI: 10.6084/m9.figshare.9735053.v1
title: Wild bumble bees (Hymenoptera: Apidae: Bombini) as a potential reservoir for bee pathogens in northeastern Argentina

description: The genus <i>Bombus</i> is represented by 38 subgenera around the world with nearly 250 described species. They are among the most efficient insect pollinators and therefore important to the ecology and the economy. In Argentina, this genus it is represented by eight native and two introduced species. Several bee pathogens related to colony losses have been found in wild pollinators around the world, including bumble bees. We studied the presence of these pathogens in bumble bee species from different locations in northeastern Argentina to determine their relationship with prevalent bee pathogens previously detected in the country. We collected 93 specimens of three bumble bee species and screened them for eleven honey bee pathogens. We detected <i>Nosema ceranae</i>, <i>Ascosphaera apis</i>, <i>Melisococcus plutonius</i>, and four viruses. Sixteen samples were pathogen-free and 77 samples contained one or more pathogens. If bumble bees are a potential reservoir for bee pathogens, this could lead to the development of Emerging Infection Diseases in wild bees. However, further studies are required to confirm this assumption and to determine the direction of the spillover between wild and managed bees.
DOI: 10.6084/m9.figshare.9735014
title: Postembryonic development of <i>Holaspulus tenuipes</i> (Berlese, 1904) (Parasitiformes: Mesostigmata: Parholaspididae)

description: <i>Holaspulus tenuipes</i> was studied under laboratory conditions using a video recording of living individuals reared on nematodes (<i>Panagrellus</i> sp.) at 20–21°C. We report the duration of juvenile stages and intra-stage changes in body length and width in juveniles (within male and female ontogenies) and male and female adults. Duration of the larva was the shortest and duration of the deutonymph was the longest. Duration of juveniles did not differ significantly between male and female ontogenies. The size of protonymphs and deutonymphs significantly increased from the first day of life to the last day before moulting. Adults increased their size significantly during the first 15 days of life. The increase in length and width from the final size of earlier instar to the initial size of the next instar was in most cases statistically significant. There were no significant differences in body length between equally aged protonymphs of both ontogenies in the first day of life while on the last day before moult female protonymphs were significantly longer. Female deutonymphs were significantly longer and wider than equally aged deutonymphs of male ontogeny. Newly emerged females were significantly longer and wider than males and a similar result was obtained after 15 days of life in adults.
DOI: 10.6084/m9.figshare.9734972
title: Transcription Factor Enrichment Analysis in Enhancers Identifies EZH2 as A Susceptibility Gene for Osteoporosis Supplementary files

description: Supplement tables 1-4 for TF enrichment analysis for osteoporosis
DOI: 10.6084/m9.figshare.9735014.v1
title: Postembryonic development of <i>Holaspulus tenuipes</i> (Berlese, 1904) (Parasitiformes: Mesostigmata: Parholaspididae)

description: <i>Holaspulus tenuipes</i> was studied under laboratory conditions using a video recording of living individuals reared on nematodes (<i>Panagrellus</i> sp.) at 20–21°C. We report the duration of juvenile stages and intra-stage changes in body length and width in juveniles (within male and female ontogenies) and male and female adults. Duration of the larva was the shortest and duration of the deutonymph was the longest. Duration of juveniles did not differ significantly between male and female ontogenies. The size of protonymphs and deutonymphs significantly increased from the first day of life to the last day before moulting. Adults increased their size significantly during the first 15 days of life. The increase in length and width from the final size of earlier instar to the initial size of the next instar was in most cases statistically significant. There were no significant differences in body length between equally aged protonymphs of both ontogenies in the first day of life while on the last day before moult female protonymphs were significantly longer. Female deutonymphs were significantly longer and wider than equally aged deutonymphs of male ontogeny. Newly emerged females were significantly longer and wider than males and a similar result was obtained after 15 days of life in adults.
DOI: 10.6084/m9.figshare.9734972.v1
title: Supplement tables 1-3

description: Supplement tables 1-3 for TF enrichment analysis for osteoporosis
DOI: 10.6084/m9.figshare.9734921
title: Supplementary Material for: Are Simple Magnetic Resonance Imaging Biomarkers Predictive of Neurodevelopmental Outcome at Two Years in Very Preterm Infants?

description: <b><i>Background:</i></b> Preterm infants are at increased risk of neurodevelopmental impairment due to the vulnerability of the immature brain. Early risk stratification is necessary for predicting outcome in the period of highest neuroplasticity. Several biomarkers in magnetic resonance imaging (MRI) at term equivalent age (TEA) have therefore been suggested. <b><i>Objective:</i></b> To assess the predictive value of simple brain metrics and the total abnormality score (TAS) – a modified score for brain injury and growth – in relation to neurodevelopmental outcome of very preterm infants in MRI at TEA. <b><i>Methods:</i></b> Single-centre cohort study including preterm infants with gestational age (GA) ≤32 weeks and birth weight ≤1,500 g. Biparietal width (BPW), interhemispheric distance, transcerebellar diameter (TCD) and TAS were assessed. To detect subtle haemorrhages, additional susceptibility-weighted imaging (SWI) was used in addition to conventional MRI to evaluate its clinical relevance. Neurodevelopment was tested by the Mental and Psychomotor Developmental Index (MDI/PDI) of the Bayley Scales of Infant Development II at a corrected age of 24 months. <b><i>Results:</i></b> One hundred twenty-nine children with median GA of 28.1 weeks and median birth weight of 980 g were included. BPW significantly correlated with PDI (<i>p</i>= 0.01, R<sup>2</sup> = 0.06) and TCD with MDI (<i>p</i> &lt; 0.01, R<sup>2</sup> = 0.05) and PDI (<i>p</i> &lt; 0.01, R<sup>2</sup> = 0.06) but explained variances were low. TAS was not predictive of neurodevelopmental outcome. By using SWI, additional 4 cases of low grade haemorrhages were identified compared to conventional sequences. In one case this additional information was clinically relevant (MDI/PDI below average). <b><i>Conclusion:</i></b> Simple brain metrics and TAS did not reliably predict neurodevelopmental outcome in a cohort with low prevalence of high grade brain injury. The additional value of SWI is yet to be determined in larger cohorts. The combination of imaging and functional biomarkers may be advisable for the prediction of neurodevelopmental outcome.
DOI: 10.6084/m9.figshare.9734930
title: Supplementary Material for: The P2X7 Receptor Is Overexpressed in the Lesional Skin of Subjects Affected by Hidradenitis Suppurativa: A Preliminary Study

description: <b><i>Background:</i></b> P2X receptors (P2XRs) are plasma membrane channels involved in the modulation of immune responses. The role of the P2X7 receptor (P2X7R) has never been investigated in hidradenitis suppurativa (HS), which is a recurrent skin disease characterized by inflammatory nodules, scarring, and suppuration. <b><i>Objective:</i></b> Our aim was to investigate by immunohistochemistry (IHC) P2X7R, NLRP3 (NOD-like receptor family, pyrin domain-containing 3), and interleukin-1β (IL-1β) expression in HS lesions compared to healthy control (HC) skin. <b><i>Method:</i></b> The intensity of IHC immunostaining was semi-quantitatively graded for keratinocytes, neutrophils, lymphocytes, and monocytes. Statistical significance was assessed by the Mann-Whitney U test, Cohen’s κ coefficient, and χ<sup>2</sup> test. <b><i>Results:</i></b> A total of 59 samples, 31 from HS and 28 from HC, were collected and analysed. In skin keratinocytes, lymphocytes, and monocytes, but not in neutrophils, P2X7R and NLRP3 protein expression was significantly increased in HS versus the HC group. IL-1β protein expression was also higher in HS versus the HC group both in skin keratinocytes and in the inflammatory infiltrate. Cohen’s κ correlation coefficients for the expression of P2X7R versus NLRP3 or IL-1β in skin keratinocytes were significant (κ = 0.43 and 0.34, respectively). The same association between P2X7R and NLRP3 or IL-1β was confirmed by χ<sup>2</sup> tests. <b><i>Conclusion:</i></b> P2X7R, NLRP3, and IL-1β are overexpressed, and therefore the entire P2X7R/NLRP3/IL-1β pro-inflammatory axis is likely overactive in the skin of HS patients. This observation might provide clues to the pathogenesis of this disease and suggest novel therapies and markers of disease activity.
DOI: 10.6084/m9.figshare.9734972.v2
title: Transcription Factor Enrichment Analysis in Enhancers Identifies Susceptibility Genes for Osteoporosis Supplementary files

description: Supplement tables 1-3 for TF enrichment analysis for osteoporosis
DOI: 10.6084/m9.figshare.9734789
title: Lavish Limo

description: <br>Address : 68 Corporate Dr, Scarborough, ON M1H 3H3, Canada<br>Phone : +1 647-524-5466<br>Fax : 416-282-4609<br>Official Email : info@lavishlimo.ca
DOI: 10.6084/m9.figshare.9734780
title: metadata_Okada2019_0708

description: metadata for Okada Y. et al. 2019
DOI: 10.6084/m9.figshare.9734795
title: Cannabis use is associated with potentially heritable widespread changes in autism candidate gene <i>DLGAP2</i> DNA methylation in sperm

description: Parental cannabis use has been associated with adverse neurodevelopmental outcomes in offspring, but how such phenotypes are transmitted is largely unknown. Using reduced representation bisulphite sequencing (RRBS), we recently demonstrated that cannabis use is associated with widespread DNA methylation changes in human and rat sperm. Discs-Large Associated Protein 2 (<i>DLGAP2)</i>, involved in synapse organization, neuronal signaling, and strongly implicated in autism, exhibited significant hypomethylation (p DLGAP2 for nine CpG sites located in intron seven (p DLGAP2 expression in human conceptal brain tissue were inversely correlated (p Dlgap2 in sperm (p
DOI: 10.6084/m9.figshare.9734789.v1
title: Lavish Limo

description: <br>Address : 68 Corporate Dr, Scarborough, ON M1H 3H3, Canada<br>Phone : +1 647-524-5466<br>Fax : 416-282-4609<br>Official Email : info@lavishlimo.ca
DOI: 10.6084/m9.figshare.9734795.v1
title: Cannabis use is associated with potentially heritable widespread changes in autism candidate gene <i>DLGAP2</i> DNA methylation in sperm

description: Parental cannabis use has been associated with adverse neurodevelopmental outcomes in offspring, but how such phenotypes are transmitted is largely unknown. Using reduced representation bisulphite sequencing (RRBS), we recently demonstrated that cannabis use is associated with widespread DNA methylation changes in human and rat sperm. Discs-Large Associated Protein 2 (<i>DLGAP2)</i>, involved in synapse organization, neuronal signaling, and strongly implicated in autism, exhibited significant hypomethylation (p DLGAP2 for nine CpG sites located in intron seven (p DLGAP2 expression in human conceptal brain tissue were inversely correlated (p Dlgap2 in sperm (p
DOI: 10.6084/m9.figshare.9734759
title: Griebel IA, Dawson RD (2019) Data from: Experimental reduction of nestling hemoglobin concentration in combination with ectoparasite load manipulation affects nestling morphology and begging behavior, but not adult behavior. Journal of Ornithology https://doi.org/10.1007/ s10336-019-01706-2

description: Young nest-bound birds often face a diversity of ectoparasites that typically feed on blood and can negatively affect nestling morphological and physiological traits, including hemoglobin concentration. While hemoglobin concentration can be correlated with nestling performance, such as body mass, it is unknown whether variation in hemoglobin is the direct proximate factor responsible for variation in morphology, or if nestling traits simply co-vary with hemoglobin concentration due to a number of similar factors influencing both traits. If hemoglobin concentration does directly influence the phenotype of nestlings, then the reduction in nestling hemoglobin concentration by ectoparasites may cause other negative effects commonly associated with parasitism. By experimentally reducing the hemoglobin concentration of nestling Tree Swallows (<i>Tachycineta bicolor</i>) using phenylhydrazine hydrochloride (PHZ), we tested whether reduced hemoglobin concentration could be the mechanism that causes changes in nestling morphology and behavior in response to increased parasitism. Parasite loads were manipulated in conjunction with the PHZ treatment. Nestlings injected with PHZ displayed no change in hemoglobin concentration 2 days post-injection, whereas control nestlings showed the typical increase that occurs during early development. By 6 days post-injection, the parasite, but not PHZ, treatment significantly affected hemoglobin concentration. Both treatments interacted to affect begging intensity, while size and growth rate of nestlings were only affected by the parasite load manipulation. This study demonstrates the potential use of PHZ in nestlings to tease apart the effects of parasitism and reduced hemoglobin, but the results suggest incorporating a second injection of PHZ to better replicate the pattern of hemoglobin reduction created by hematophagous ectoparasites.