cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.22721990
title: Effect of combined sedation using multiple drugs on inflammatory cytokines in patients with acute respiratory distress syndrome

description: Abstract The innate immune response plays an important role in the pathophysiology of acute respiratory distress syndrome (ARDS); however, no drug has been proven to be beneficial in the management of ARDS. Therefore, the aim of this study was to investigate the effects of using combined sedatives on systemic inflammatory responses in patients with ARDS. A total of 90 patients with ARDS and an intubation time of &gt; 120 h were randomly divided into the propofol group (group P), midazolam group (group M), and combined sedation group (group U). Patients in groups P and M were sedated with propofol and midazolam, respectively, whereas patients in group U were sedated with a combination of propofol, midazolam, and dexmedetomidine. The dosage of sedatives and vasoactive drugs, duration of mechanical ventilation, and incidence of sedative adverse reactions were documented. The dosage of sedatives and vasoactive drugs, as well as the incidence of sedative adverse reactions in group U, was significantly lower than those in groups P and M. Similarly, the duration of mechanical ventilation in group U was significantly shorter than that in groups P and M. Hence, inducing sedation through a combination of multiple drugs can significantly reduce their adverse effects, improve their sedative effect, inhibit systemic inflammatory responses, and improve oxygenation in patients with ARDS.
DOI: 10.6084/m9.figshare.21679035
title: EEG datasets of stroke patients

description:  
This data set consists of electroencephalography (EEG) data from 50 (Subject1 – Subject50) participants with acute ischemic stroke aged between 30 and 77 years. The participants included 39 male and 11 female. The time after stroke ranged from 1 days to 30 days. 22 participants had right hemisphere hemiplegia and 28 participants had left hemisphere hemiplegia. All participants were originally right-handed.
Each of the participants sat in front of a computer screen with an arm resting on a pillow on their lap or on a table and they carried out the instructions given on the computer screen. At the trial start, a picture with text description which was circulated with left right hand, were presented for 2s. We asked the participants to focus their mind on the hand motor imagery which was instructed, at the same time, the video of ipsilateral hand movement is displayed on the computer screen and lasts for 4s. Next, take a 2s break.
DOI: 10.6084/m9.figshare.22721789.v1
title: Baseline predictors of short-term visual outcomes after intravitreal conbercept injection for neovascular age-related macular degeneration

description: ABSTRACT Purpose: Neovascular age-related macular degeneration is the leading cause of vision loss in the elderly. We aimed to identify baseline predictors of visual prognosis after intravitreal conbercept injection for neovascular age-related macular degeneration. Methods: We conducted a retrospective review of 58 patients with neovascular age-related macular degeneration who were treated with intravitreal injections of conbercept 0.5 mg in routine clinical practice. Basic information such as age, sex, intraocular pressure, and disease course was collected. Best-corrected visual acuity, mean retinal sensitivity, and optical coherence tomography findings were recorded at baseline and 6 months after treatment. Logistic regression analysis was used to identify independent predictors of best-corrected visual acuity at 6 months after treatment. Results: After the 6-month treatment, the mean best-corrected visual acuity improved from 1.10 ± 0.42 logarithm of the minimum angle of resolution (logMAR) to 0.41 ± 0.18 logMAR, the mean retinal sensitivity increased from 5.13 ± 0.86 dB to 7.32 ± 1.21 dB, the mean central retinal thickness decreased from 440.38 ± 61.05 μm to 260.01 ± 24.86 μm, and the total number of hyperreflective dots and the number of hyperreflective dots in each retina layer were significantly reduced as compared with those before treatment (all p&lt;0.05). Twenty-two patients showed improved vision, and 36 had unimproved vision. Multivariate analyses revealed that the number of subretinal hyperreflective dots, the state of external limiting membrane, baseline best-corrected visual acuity, and age were independent predictors of best-corrected visual acuity (all p&lt;0.05). Conclusion: Poor recovery of patients after intravitreal conbercept injection may be related to the number of subretinal hyperreflective dots, the state of external limiting membrane, baseline best-corrected visual acuity, and age, which may be used as predictors of short-term visual outcomes and should be fully evaluated before operation.
DOI: 10.4121/5e55cf64-7912-4b07-8b8e-c2afb067c3e7
title: Dataset on the PhD thesis "Heritage Beyond Singular Narratives: Embracing Diversity in Participatory Heritage Planning Empowered by Artificial Intelligence"

description: By comparing the different stakeholders’ perspectives, discovered using an AI approach from multiple unstructured data sources, this research develops an approach to reveal alignments and conflicts between academic experts, policymakers, and users to shed light on the conflicts and alignments embedded in the multi-stakeholder setting and as a step further towards inclusive data-supported heritage planning. To provide empirical evidence of such an approach, thisresearch explores various stakeholders’ perspectives on the cultural significance conveyed to a specific case study, the city of Yazd, Iran. The focus of research is on windcatchers which are key attributes conveying outstanding universal value, as inscribed on the UNESCO World Heritage List (UNESCO, 2017). This research discusses alignments and conflicts in the attributes and values, by comparing the perspectives of policy makers, users, and academic experts. Based on the analysis, a critical reflection on the changes expected in heritage planning is discussed. This study offers a comprehensive methodology with a customized AI-supported tool to detect alignments and conflicts in participation processes applied to heritage planning. Besides, this study reveals a critical gap that requires more reflection on the changes expected in heritage planning, by considering how different stakeholders may grow in their contribution to the definition of cultural significance in heritage planning, given the rising importance of public participation.These datasets contain the opinions of three main stakeholdr groups on the cultural significance of windcatchers in Yazd, Iran:experts (academic publications)users (social media: Instagram and Twitter/X)policy makers (local/national/international documents) <br>The analysis results have been published in journal papers, conference papers, and a book chapter. <br>There are three Excel files containing various sheets:general information: the publications' information namely, title, year of publication, authors, etc.sentences_values: titles, relevant sentences, and values addressed in the sentencessentences_attributes: titles, relevant sentences, and attributes addressed in the sentencesname entity recognition (NER): relevant sentences, relevant words, and the class of NER associated with the wordsentiment and emotion analysis: relevant sentences, sentiments, emotions<br>
DOI: 10.6084/m9.figshare.11393829.v1
title: MOESM5 of A KHDC3L mutation resulting in recurrent hydatidiform mole causes genome-wide DNA methylation loss in oocytes and persistent imprinting defects post-fertilisation

description: Additional file 5 : Table S4. Hypomethylated regions in KHDC3Lc.1A&gt;G mole; .xls, 56â€‰KB
DOI: 10.6084/m9.figshare.11393829
title: MOESM5 of A KHDC3L mutation resulting in recurrent hydatidiform mole causes genome-wide DNA methylation loss in oocytes and persistent imprinting defects post-fertilisation

description: Additional file 5 : Table S4. Hypomethylated regions in KHDC3Lc.1A&gt;G mole; .xls, 56â€‰KB
DOI: 10.6084/m9.figshare.7517516.v1
title: Comparison of the effects of albumin and crystalloid on mortality among patients with septic shock: systematic review with meta-analysis and trial sequential analysis

description: ABSTRACT BACKGROUND: This study aimed to compare the effects on mortality of albumin and crystalloid, used for fluid resuscitation among adult patients with septic shock, through conducting a meta-analysis and trial sequential analysis (TSA). DESIGN AND SETTING: Meta-analysis and TSA conducted at Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, China. METHODS: Data were collected from several major databases including MEDLINE, EMBASE, Clinical Trials.gov and Cochrane Central Register of Controlled Trials. Studies that compared the effects of albumin therapy versus crystalloid therapy on mortality among adult septic shock patients were eligible for inclusion in the analyses. The study name, year of publication, country of the trial, albumin concentration, type of crystalloid and all reported mortalities at different follow-up endpoints were extracted. RESULTS: Compared with crystalloid, albumin did not decrease all-cause mortality at the final follow-up. However, in TSA, the required information size was not achieved in all groups, which means that the effect size was not definitive and further RCTs are needed to confirm or deny these findings CONCLUSIONS: Compared with crystalloid solutions, albumin was unable to decrease all-cause mortality. However, TSA indicated that these results could be false-negative. Additional randomized controlled trials are needed to clarify this discrepancy.
DOI: 10.6084/m9.figshare.22721449
title: Additional file 5 of Apoptosis related genes mediated molecular subtypes depict the hallmarks of the tumor microenvironment and guide immunotherapy in bladder cancer

description: Additional file 5. Supplementary table 5. List of 2859 ARGs phenotype-related prognostic genes used in this study.
DOI: 10.6084/m9.figshare.6993068
title: MOESM1 of iTRAQ-based analysis of sperm proteome from normozoospermic men achieving the rescue-ICSI pregnancy after the IVF failure

description: Additional file 1: Supplementary Table 1. The quantitative details of sperm proteins from normozoospermic men between the IVF pregnancy group and the R-ICSI pregnancy group.
DOI: 10.6084/m9.figshare.6993068.v1
title: MOESM1 of iTRAQ-based analysis of sperm proteome from normozoospermic men achieving the rescue-ICSI pregnancy after the IVF failure

description: Additional file 1: Supplementary Table 1. The quantitative details of sperm proteins from normozoospermic men between the IVF pregnancy group and the R-ICSI pregnancy group.
DOI: 10.6084/m9.figshare.22721983.v1
title: Ansai peasant paintings: inheritance of chinese primitive culture and primitive philosophy

description: Abstract: Chinese primitive philosophy, as the unity of cosmological ontology, epistemology and methodology of the Chinese philosophical system, is a complete and mature philosophical system formed in the late primitive society as early as before the Xia, Shang and Zhou Dynasties. It is also the unity of the concept of Yin and Yang and constant life that is sublimated from the human-beings’ basic cultural consciousness: life consciousness and reproduction consciousness. The Chinese primitive culture, from the painted pottery culture 7,000 years ago to today, from the underground archaeological culture to the group culture on the ground, is a plastic art based on the concept of viewing objects and taking images. It is a broad concept of fine arts that determines the philosophical view, artistic view, emotional temperament, psychological quality and national spirit of the Chinese nation. The most primitive culture and primitive philosophy in China have been preserved with extremely rich and complete historical remains in the group’s cultural and social life. It is for this reason that China is the only country with an ancient history of civilization that has not experienced a cultural break. The primitive culture and philosophical system of China, as the philosophical basis and main connotation of ethnic group culture, are completely accumulated in the ethnic groups’ social life. Folk art, which has accumulated the hundreds of millions of working masses’ wisdom in China, is the mother of the Chinese national culture and art that has been inherited from primitive society until today with distinct national and regional characteristics. It is a long-standing cultural form with the longest history, the widest mass participation, the most distinct regional characteristics and the richest cultural connotation in the Chinese national cultural form. The rapid development of the times makes the traditional folk customs and folk arts, which are generally deposited in the rural areas of China, become precarious. As a result, the research advantages of the unique human culture and the original culture of China will cease to exist. Therefore, it is an urgent historical task to make use of this advantage to study the original culture of China and the philosophical genes of the Chinese nation. Protection is imminent, and inheritance is the historical mission, which highlights the deeper significance of studying primitive culture and primitive philosophy in modern society.
DOI: 10.6084/m9.figshare.7517810
title: Application of Multidisciplinary Design Optimization on Advanced Configuration Aircraft

description: ABSTRACT: An optimization strategy is constructed to solve the aerodynamic and structural optimization problems in the conceptual design of double-swept flying wing aircraft. Aircraft preliminary aerodynamic and structural design optimization is typically based on the application of a deterministic approach of optimizing aerodynamic performance and structural weight. In aerodynamic optimization, the objective is to minimize induced drag coefficient, and the structural optimization aims to find the minimization of the structural weight. In order to deal with the multiple objective optimization problems, an optimization strategy based on collaborative optimization is adopted. Based on the optimization strategy, the optimization process is divided into system level optimization and subsystem level optimization. The system level optimization aims to obtain the optimized design which meets the constraints of all disciplines. In subsystem optimization, the optimization process for different disciplines can be executed simultaneously to search for the consistent schemes. A double-swept configuration of flying wing aircraft is optimized through the suggested optimization strategy, and the optimization results demonstrate the effectiveness of the method.
DOI: 10.6084/m9.figshare.6993458
title: Transcriptome analysis of <i>Lilium Oriental</i> × <i>Trumpet</i> hybrid roots reveals auxin-related genes and stress-related genes involved in picloram-induced somatic embryogenesis induction

description: Highly efficient somatic embryogenesis (SE) initiation systems are crucial for the clonal propagation and genetic transformation of <i>Lilium Oriental</i> × <i>Trumpet</i> hybrid. To elucidate the underlying mechanism of SE induction, we conducted <i>de novo</i> transcriptome sequencing of the roots at four different times in relation to SE initiation (0 days, control; 20 days, embryogenic callus induction (ECI) 1; 40 days, ECI2; 55 days, ECI3). A total of 4621, 7582, and 7427 differentially expressed genes (DEGs) were identified from the ECI1 vs. control, ECI2 vs. control, and ECI3 vs. control comparisons, respectively. The gene-enrichment analysis revealed 54 significant DEGs. Further analysis showed that the transcript levels of the auxin-related genes <i>ARF9/15/16</i>, the abscisic acid-related (ABA-related) genes <i>PYL4/9</i>, and stress-related transcription factors, including <i>WRKY26, MYB36, NAC100, bHLH2</i>/<i>5</i>/<i>18</i>/<i>112</i>, and <i>HSP90</i>, were increased at the ECI1 stage. <i>ABI5 </i>can influence the expression of stress-responsive genes as an ABA signalling regulator. The upregulated <i>ABI5 </i>could be caused by the increased <i>ARF9/15/16, PYL4/9, WRKY26, MYB36, NAC100, bHLH2</i>/<i>5</i>/<i>18</i>/<i>112</i>, and <i>HSP90 </i>at the ECI2 and ECI3 stages to regulate the ECI. These genes had the most abundant transcripts among the DEGs, indicating that auxin and stress-related signalling pathways are involved in SE initiation of <i>Lilium</i> spp.
DOI: 10.6084/m9.figshare.7517513.v1
title: The Theoretical Research for the Rotor/Fuselage Unsteady Aerodynamic Interaction Problem

description: ABSTRACT Based on coupled unsteady panel/free-wake method, a universal analysis model was established, which provides a good prediction for the rotor/fuselage unsteady aerodynamic interaction. Considering the deficiencies of the traditional time-marching rotor free-wake algorithms, notably on stability and efficiency, the CB3D algorithm with 3rd-order accuracy is proposed. For solving the problem that part of the wake vortices may penetrate the fuselage, a “material line” rectification method with 3rd-order accuracy is proposed. An analysis for the model accuracy was then conducted to validate the accuracy of the new model, and a comparison against the available experimental data is performed. The simulated results show a good agreement with these experimental data. With the new model, several simulations are conducted for the typical rotor/fuselage aerodynamic interaction, and the results are analyzed.
DOI: 10.6084/m9.figshare.19576191
title: m<sup>6</sup>A RNA demethylase FTO promotes the growth, migration and invasion of pancreatic cancer cells through inhibiting TFPI-2

description: Pancreatic cancer (PC) is one of the most fatal cancers with a very poor prognosis. Here, we found that N<sup>6</sup>-methyladenosine (m<sup>6</sup>A) RNA demethylase fat mass and obesity-related protein (FTO) promote the growth, migration and invasion of PC. FTO expression level is increased in human PC and is associated with poor prognosis of PC patients. Knockdown of FTO increases m<sup>6</sup>A methylation of TFPI-2 mRNA in PC cells, thereby increasing mRNA stability via the m<sup>6</sup>A reader YTHDF1, resulting in up-regulation of TFPI-2 expression, and inhibits PC proliferation, colony formation, sphere formation, migration and invasion <i>in vitro</i>, as well as tumour growth <i>in vivo</i>. Rescue assay further confirms that FTO facilitates cancer progression by reducing the expression of TFPI-2. Mechanistically, FTO promotes the progression of PC at least partially through reducing m<sup>6</sup>A/YTHDF1 mediated TFPI-2 mRNA stability. Our findings reveal that FTO, as an m<sup>6</sup>A demethylase, plays a critical role in promoting PC growth, migration and invasion, suggesting that FTO may be a potential therapeutic target for treating PC.
DOI: 10.6084/m9.figshare.19576191.v1
title: m<sup>6</sup>A RNA demethylase FTO promotes the growth, migration and invasion of pancreatic cancer cells through inhibiting TFPI-2

description: Pancreatic cancer (PC) is one of the most fatal cancers with a very poor prognosis. Here, we found that N<sup>6</sup>-methyladenosine (m<sup>6</sup>A) RNA demethylase fat mass and obesity-related protein (FTO) promote the growth, migration and invasion of PC. FTO expression level is increased in human PC and is associated with poor prognosis of PC patients. Knockdown of FTO increases m<sup>6</sup>A methylation of TFPI-2 mRNA in PC cells, thereby increasing mRNA stability via the m<sup>6</sup>A reader YTHDF1, resulting in up-regulation of TFPI-2 expression, and inhibits PC proliferation, colony formation, sphere formation, migration and invasion <i>in vitro</i>, as well as tumour growth <i>in vivo</i>. Rescue assay further confirms that FTO facilitates cancer progression by reducing the expression of TFPI-2. Mechanistically, FTO promotes the progression of PC at least partially through reducing m<sup>6</sup>A/YTHDF1 mediated TFPI-2 mRNA stability. Our findings reveal that FTO, as an m<sup>6</sup>A demethylase, plays a critical role in promoting PC growth, migration and invasion, suggesting that FTO may be a potential therapeutic target for treating PC.
DOI: 10.6084/m9.figshare.7517513
title: The Theoretical Research for the Rotor/Fuselage Unsteady Aerodynamic Interaction Problem

description: ABSTRACT Based on coupled unsteady panel/free-wake method, a universal analysis model was established, which provides a good prediction for the rotor/fuselage unsteady aerodynamic interaction. Considering the deficiencies of the traditional time-marching rotor free-wake algorithms, notably on stability and efficiency, the CB3D algorithm with 3rd-order accuracy is proposed. For solving the problem that part of the wake vortices may penetrate the fuselage, a “material line” rectification method with 3rd-order accuracy is proposed. An analysis for the model accuracy was then conducted to validate the accuracy of the new model, and a comparison against the available experimental data is performed. The simulated results show a good agreement with these experimental data. With the new model, several simulations are conducted for the typical rotor/fuselage aerodynamic interaction, and the results are analyzed.
DOI: 10.6084/m9.figshare.7517810.v1
title: Application of Multidisciplinary Design Optimization on Advanced Configuration Aircraft

description: ABSTRACT: An optimization strategy is constructed to solve the aerodynamic and structural optimization problems in the conceptual design of double-swept flying wing aircraft. Aircraft preliminary aerodynamic and structural design optimization is typically based on the application of a deterministic approach of optimizing aerodynamic performance and structural weight. In aerodynamic optimization, the objective is to minimize induced drag coefficient, and the structural optimization aims to find the minimization of the structural weight. In order to deal with the multiple objective optimization problems, an optimization strategy based on collaborative optimization is adopted. Based on the optimization strategy, the optimization process is divided into system level optimization and subsystem level optimization. The system level optimization aims to obtain the optimized design which meets the constraints of all disciplines. In subsystem optimization, the optimization process for different disciplines can be executed simultaneously to search for the consistent schemes. A double-swept configuration of flying wing aircraft is optimized through the suggested optimization strategy, and the optimization results demonstrate the effectiveness of the method.
DOI: 10.6084/m9.figshare.11393808.v1
title: MOESM1 of A KHDC3L mutation resulting in recurrent hydatidiform mole causes genome-wide DNA methylation loss in oocytes and persistent imprinting defects post-fertilisation

description: Additional file 1 : Table S1: List of gDMR coordinates; list of ZFP57 binding sites in gDMRs; .xls, 25â€‰KB.
DOI: 10.6084/m9.figshare.14936106
title: Additional file 1 of Full-length transcriptome analysis reveals the mechanism of acupuncture at PC6 improves cardiac function in myocardial ischemia model

description: Additional file 1: Table S1. The differentially expressed genes in MI group compared to Control group.