cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.14271965.v1
title: One periphery, two centers: the municipality of Praia Grande in the context of the formation of the macrometropolis of São Paulo at the beginning of the 21st century

description: Abstract The present study has two main objectives: the first one is to discuss the impacts, consequences and demographic responses of the process of expansion and structuring of large urban agglomerations, with special focus on the case of Praia Grande/SP in the Metropolitan Area of Baixada Santista; the second one, to examine in more detail the nuances of population mobility and, in particular, migratory modalities (and their characteristics), as important elements of the peculiar regional insertion of that municipality as “simultaneous periphery” of two metropolitan areas. Based on the exhaustive use of census data, especially the Demographic Census of 2000 and 2010, this study presents an analysis of the growth and territorial expansion of Praia Grande emphasizing, at intra-municipal level, the role of the different migration modalities (intra-metropolitan and inter-regional). In addition, it seeks to associate them to different motivations from a detailed look at the sociodemographic profile of established flows. As main results of the work, it was observed that the role of Praia Grande as an area of metropolitan expansion of RMBS is supported by the growing intra-metropolitan migratory flows from the regional core, a reality that can also be observed in other metropolitan contexts. However, as a peculiarity of its process of occupation and regional insertion, a major part of this migration comes from outside the RMBS, more precisely, from the municipality of São Paulo, the center of another important metropolitan area, a fact that contributes to characterize Praia Grande as a “periphery with two centers”.
DOI: 10.6084/m9.figshare.7511831.v1
title: Experience with pegvisomant treatment in acromegaly in a single Brazilian tertiary reference center: efficacy, safety and predictors of response

description: ABSTRACT Objective To describe the safety and efficacy of pegvisomant therapy and the predictors of treatment response in acromegaly patients at a single tertiary reference center in Brazil. Materials and methods We retrospectively reviewed the clinical, hormonal and radiological data of acromegaly patients treated with pegvisomant in our center. We also evaluated the presence of the d3 isoform of the growth hormone receptor (d3GHR). Results Twenty-seven patients were included (17 women). Pegvisomant was used in combination with octreotide LAR in 20 patients (74%), in combination with cabergoline in one (4%) and as monotherapy in six (22%). IGF-I normalization was achieved in 23 patients (85%). Mild and transitory elevation of liver enzymes was observed in two patients (7.4%), tumor growth in one (3.4%) and lipodystrophy in two (7.4%). One patient stopped the drug due to headaches. The GHR isoforms were evaluated in 14 patients, and the presence of at least one d3GHR allele was observed in 43% of them, but it was not a predictor of treatment response. Only pre-treatment IGF-I level was a predictor of treatment response. Conclusion Pegvisomant treatment was highly effective and safe in our series of Brazilian patients. A better chance of disease control can be expected in those with lower pre-pegvisomant IGF-I levels.
DOI: 10.6084/m9.figshare.7515494
title: Feed efficiency and meat quality of crossbred beef heifers classified according to residual feed intake

description: AbstractThis study aimed to evaluate feed efficiency and meat quality of 31 three-crossbred beef heifers during 84 days in a feedlot system. A 60:40 concentrate and sorghum silage ration on DM basis (ME = 2.73Mcal/kg of DM, CP = 11.90% DM) was fed ad libitum. Based on residual feed intake (RFI) calculations, the heifers were ranked in three groups of feed efficiency: High RFI (average mean = 0.776; n = 9), medium RFI (average mean = -0.010; n = 11), and low RFI (average mean = - 0.624; n = 11). High RFI heifers consumed 4.56% more DM per day than low RFI heifers (P &lt;0.05). The ADG did not differ (P&gt; 0.05) among RFI groups (1.40kg/day). No differences (P&gt;0.05) were detected for digestibility of the nutrients: DM (64.00%), CP (60.01%), crude fat (72.90%), NDF (54.80%) and non-fibrous carbohydrate (NFC) (78.91%). There were no differences between low and high RFI groups for slaughter weight (475.00 vs. 479.55kg), hot carcass weight (259.09 vs. 261.44kg), Longissimus dorsi (LD) area (69.02 vs. 68.11 cm2), back-fat thickness (5.74 vs. 6.26 cm), shear force (5.45 vs. 5.19kg), sensorial traits of LD muscle, LD color (intensities L=40.47 a*=24.74 and b*=16.13) or commercial cuts yield. Low RFI heifers presented similar meat quality and carcass traits as high RFI heifers, however low RFI heifers consumed less DM (kg/d).
DOI: 10.6084/m9.figshare.7511831
title: Experience with pegvisomant treatment in acromegaly in a single Brazilian tertiary reference center: efficacy, safety and predictors of response

description: ABSTRACT Objective To describe the safety and efficacy of pegvisomant therapy and the predictors of treatment response in acromegaly patients at a single tertiary reference center in Brazil. Materials and methods We retrospectively reviewed the clinical, hormonal and radiological data of acromegaly patients treated with pegvisomant in our center. We also evaluated the presence of the d3 isoform of the growth hormone receptor (d3GHR). Results Twenty-seven patients were included (17 women). Pegvisomant was used in combination with octreotide LAR in 20 patients (74%), in combination with cabergoline in one (4%) and as monotherapy in six (22%). IGF-I normalization was achieved in 23 patients (85%). Mild and transitory elevation of liver enzymes was observed in two patients (7.4%), tumor growth in one (3.4%) and lipodystrophy in two (7.4%). One patient stopped the drug due to headaches. The GHR isoforms were evaluated in 14 patients, and the presence of at least one d3GHR allele was observed in 43% of them, but it was not a predictor of treatment response. Only pre-treatment IGF-I level was a predictor of treatment response. Conclusion Pegvisomant treatment was highly effective and safe in our series of Brazilian patients. A better chance of disease control can be expected in those with lower pre-pegvisomant IGF-I levels.
DOI: 10.6084/m9.figshare.7515494.v1
title: Feed efficiency and meat quality of crossbred beef heifers classified according to residual feed intake

description: AbstractThis study aimed to evaluate feed efficiency and meat quality of 31 three-crossbred beef heifers during 84 days in a feedlot system. A 60:40 concentrate and sorghum silage ration on DM basis (ME = 2.73Mcal/kg of DM, CP = 11.90% DM) was fed ad libitum. Based on residual feed intake (RFI) calculations, the heifers were ranked in three groups of feed efficiency: High RFI (average mean = 0.776; n = 9), medium RFI (average mean = -0.010; n = 11), and low RFI (average mean = - 0.624; n = 11). High RFI heifers consumed 4.56% more DM per day than low RFI heifers (P &lt;0.05). The ADG did not differ (P&gt; 0.05) among RFI groups (1.40kg/day). No differences (P&gt;0.05) were detected for digestibility of the nutrients: DM (64.00%), CP (60.01%), crude fat (72.90%), NDF (54.80%) and non-fibrous carbohydrate (NFC) (78.91%). There were no differences between low and high RFI groups for slaughter weight (475.00 vs. 479.55kg), hot carcass weight (259.09 vs. 261.44kg), Longissimus dorsi (LD) area (69.02 vs. 68.11 cm2), back-fat thickness (5.74 vs. 6.26 cm), shear force (5.45 vs. 5.19kg), sensorial traits of LD muscle, LD color (intensities L=40.47 a*=24.74 and b*=16.13) or commercial cuts yield. Low RFI heifers presented similar meat quality and carcass traits as high RFI heifers, however low RFI heifers consumed less DM (kg/d).
DOI: 10.6084/m9.figshare.8127827
title: Optimizing the Communication Capacity of a Ground Station Network

description: ABSTRACT: Small satellites are growing in use for educational, scientific, and commercial purposes, usually in Low Earth Orbit (LEO) flights, given their lower costs and associated risks, as well as smaller lead times for assembling and testing. However, the typically short periods of LEO passes bring the need to find ways of optimizing the communication between the ground and space segments. In that direction, several projects have relied on ground station networks to increase the total time of contact with the satellites. In this type of arrangement, the stations agree in monitoring one or more satellites in such a way that, as the spacecraft exits one station’s field of view, another station assumes its tracking, extending the total communication time and compensating the short passes. This type of solution, while very efficient in terms of costs, on the other hand demands a good synchronization procedure, so that all constraints present in its operations are taken into account and the network can operate effectively. This paper aims at describing a model implemented for orchestrating ground station networks that optimizes the communication capacity of the ground network, while taking into account physical constraints not usually considered in other models currently proposed.
DOI: 10.6084/m9.figshare.8127827.v1
title: Optimizing the Communication Capacity of a Ground Station Network

description: ABSTRACT: Small satellites are growing in use for educational, scientific, and commercial purposes, usually in Low Earth Orbit (LEO) flights, given their lower costs and associated risks, as well as smaller lead times for assembling and testing. However, the typically short periods of LEO passes bring the need to find ways of optimizing the communication between the ground and space segments. In that direction, several projects have relied on ground station networks to increase the total time of contact with the satellites. In this type of arrangement, the stations agree in monitoring one or more satellites in such a way that, as the spacecraft exits one station’s field of view, another station assumes its tracking, extending the total communication time and compensating the short passes. This type of solution, while very efficient in terms of costs, on the other hand demands a good synchronization procedure, so that all constraints present in its operations are taken into account and the network can operate effectively. This paper aims at describing a model implemented for orchestrating ground station networks that optimizes the communication capacity of the ground network, while taking into account physical constraints not usually considered in other models currently proposed.
DOI: 10.6084/m9.figshare.7507628
title: Dental Care for an adolescent with chromosome pentasomy: rare case report with a two year follow-up

description: Pentasomy of the x chromosome is a rare syndrome of unknown incidence and there are few reports in the scientific literature, especially in terms of dental care for patients with this syndrome. The aim of this study was to report the dental care given to an adolescent with pentasomy of the X chromosome. The patient presented a cleft palate, impacted teeth, malocclusion, high caries activity, gingivitis and multiple tooth loss due to caries. Despite the difficulties of carrying out the dental work due to involuntary movements and the initial lack of collaboration from the patient the overall dental care was completed on an outpatient basis. The therapeutic success of the treatment was strongly supported by the significant cooperation and relationship that grew up along the period of the treatment, as well as the desire to have the treatment done by both the patient and her parents.
DOI: 10.6084/m9.figshare.7507628.v1
title: Dental Care for an adolescent with chromosome pentasomy: rare case report with a two year follow-up

description: Pentasomy of the x chromosome is a rare syndrome of unknown incidence and there are few reports in the scientific literature, especially in terms of dental care for patients with this syndrome. The aim of this study was to report the dental care given to an adolescent with pentasomy of the X chromosome. The patient presented a cleft palate, impacted teeth, malocclusion, high caries activity, gingivitis and multiple tooth loss due to caries. Despite the difficulties of carrying out the dental work due to involuntary movements and the initial lack of collaboration from the patient the overall dental care was completed on an outpatient basis. The therapeutic success of the treatment was strongly supported by the significant cooperation and relationship that grew up along the period of the treatment, as well as the desire to have the treatment done by both the patient and her parents.
DOI: 10.6084/m9.figshare.9739610
title: Sutures modified by incorporation of chlorhexidine and cinnamaldehyde: anti-Candida effect, bioavailability and mechanical properties

description: Abstract Introduction Antimicrobial sutures are a therapeutic alternative for the control of oral infections. Objective Incorporate Chlorhexidine (CHX) and Cinnamaldehyde (CN) in sutures and evaluate the anti-Candida effect, release of antimicrobials and mechanical properties. Material and method Silk (S) and Polyglactin 910 (P) sutures were aseptically sectioned (20 mm) and immersed for incorporation in 0.12% CHX, 0.4% CN and 0.9% saline solutions under stirring for 60 minutes (n = 10 / group). Suspensions of 500 μL of Candida albicans (ATCC 90028/ 1 × 106 CFU/mL) were used to evaluate fungal adhesion after the 48 h period at 37°C. The release of CLX and CN were evaluated at 0, 24 and 48 hours (n=3/group) by UV-VIS spectrophotometer (275 nm). The tensile strength and displacement (n=5/group) were evaluated after incorporation (30 mm/min, 50N). Data were analyzed by Anova and Tukey (α = 5%). Result No anti-Candida effect was observed on S and P sutures incorporated with CLX and CN (p&gt;0.05). However, progressive release was verified up to 48 after treatment with CLX (S = 0.075 / P = 0.073 μg/mL) and CN (S = 35.33 /P= 5.72 μg/mL). There was a decrease in tensile strength in S (CLX = 9.9 / CN = 9.9 N) and P (CLX = 14.4 / CN = 15.5 N) (p&lt;0.05). No differences were observed for the displacement for S (CLX = 19.3 / CN=20.7 mm) and P (CLX = 16.2 / CN=15.8 mm) (p&gt;0.05). Conclusion The incorporation of CLX and CN did not have a positive effect on the biological and mechanical properties of the sutures evaluated.
DOI: 10.6084/m9.figshare.9739610.v1
title: Sutures modified by incorporation of chlorhexidine and cinnamaldehyde: anti-Candida effect, bioavailability and mechanical properties

description: Abstract Introduction Antimicrobial sutures are a therapeutic alternative for the control of oral infections. Objective Incorporate Chlorhexidine (CHX) and Cinnamaldehyde (CN) in sutures and evaluate the anti-Candida effect, release of antimicrobials and mechanical properties. Material and method Silk (S) and Polyglactin 910 (P) sutures were aseptically sectioned (20 mm) and immersed for incorporation in 0.12% CHX, 0.4% CN and 0.9% saline solutions under stirring for 60 minutes (n = 10 / group). Suspensions of 500 μL of Candida albicans (ATCC 90028/ 1 × 106 CFU/mL) were used to evaluate fungal adhesion after the 48 h period at 37°C. The release of CLX and CN were evaluated at 0, 24 and 48 hours (n=3/group) by UV-VIS spectrophotometer (275 nm). The tensile strength and displacement (n=5/group) were evaluated after incorporation (30 mm/min, 50N). Data were analyzed by Anova and Tukey (α = 5%). Result No anti-Candida effect was observed on S and P sutures incorporated with CLX and CN (p&gt;0.05). However, progressive release was verified up to 48 after treatment with CLX (S = 0.075 / P = 0.073 μg/mL) and CN (S = 35.33 /P= 5.72 μg/mL). There was a decrease in tensile strength in S (CLX = 9.9 / CN = 9.9 N) and P (CLX = 14.4 / CN = 15.5 N) (p&lt;0.05). No differences were observed for the displacement for S (CLX = 19.3 / CN=20.7 mm) and P (CLX = 16.2 / CN=15.8 mm) (p&gt;0.05). Conclusion The incorporation of CLX and CN did not have a positive effect on the biological and mechanical properties of the sutures evaluated.
DOI: 10.6084/m9.figshare.11267762.v1
title: Compared activity of agonist molecules towards ecdysone receptor in insect cell-based screening system

description: ABSTRACT: The ecdysone receptor, naturally activated by steroidal hormones, is a key protein for molting and reproduction processes of insects. Artificial activation of such receptor by specific pesticides induces an anomalous process of ecdysis, causing death of insects by desiccation and starvation. In this paper, we established a protocol for screening agonistic molecules towards ecdysone receptor of insect cells line S2 (Diptera) and Sf9 (Lepidoptera), transfected with the reporter plasmid ere.b.act.luc. Therefore, we set dose-response curves with the ecdysteroid 20-hydroxyecdysone, the phytoecdysteroid ponasterone-A, and tebufenozide, a pesticide belonging to the class of diacylhydrazines. In both cell lines, the median effective concentration values on reporter gene induction (EC50) of ponasterone-A was the smallest, meaning the most active agonist molecule. In Sf9 cells, tebufenozide had as smaller EC50 than 20-hydroxyecdysone, indicating the high agonistic capability and lepidopteran specificity. The protocol established in this study can be useful for a quick screening and rational research of site-specific pesticides.
DOI: 10.6084/m9.figshare.7515191
title: Oral health assessment from the perspective of the municipal manager

description: ABSTRACT Objective: The aim of this study was to conduct a situational diagnosis related to the organization of oral health services in 40 municipalities of São Paulo State, Brazil. Methods: This is a cross-sectional, quantitative and qualitative, descriptive study performed through document analysis and application of a semi-structured questionnaire to oral health coordinators, in 2014. The following items were defined: dental infrastructure, access and regulation, work organization and assessment strategies. Although the Basic Health Unit is the main gateway to the system, dental care was also conducted in schools; the main service access of the population was the spontaneous demand and there have been production data inconsistencies in the information systems. Results: It was observed that, 60% answered that the health planning process included oral health; 47.5% performed risk assessment; 47.5% did not perform evaluation and monitoring of results. Conclusion: It is concluded that municipalities present different moments in the structuring of the service and that managers should improve the access organization, the work process and service evaluation in order to consolidate the universality and comprehensiveness of health care.
DOI: 10.6084/m9.figshare.11267762
title: Compared activity of agonist molecules towards ecdysone receptor in insect cell-based screening system

description: ABSTRACT: The ecdysone receptor, naturally activated by steroidal hormones, is a key protein for molting and reproduction processes of insects. Artificial activation of such receptor by specific pesticides induces an anomalous process of ecdysis, causing death of insects by desiccation and starvation. In this paper, we established a protocol for screening agonistic molecules towards ecdysone receptor of insect cells line S2 (Diptera) and Sf9 (Lepidoptera), transfected with the reporter plasmid ere.b.act.luc. Therefore, we set dose-response curves with the ecdysteroid 20-hydroxyecdysone, the phytoecdysteroid ponasterone-A, and tebufenozide, a pesticide belonging to the class of diacylhydrazines. In both cell lines, the median effective concentration values on reporter gene induction (EC50) of ponasterone-A was the smallest, meaning the most active agonist molecule. In Sf9 cells, tebufenozide had as smaller EC50 than 20-hydroxyecdysone, indicating the high agonistic capability and lepidopteran specificity. The protocol established in this study can be useful for a quick screening and rational research of site-specific pesticides.
DOI: 10.6084/m9.figshare.7515191.v1
title: Oral health assessment from the perspective of the municipal manager

description: ABSTRACT Objective: The aim of this study was to conduct a situational diagnosis related to the organization of oral health services in 40 municipalities of São Paulo State, Brazil. Methods: This is a cross-sectional, quantitative and qualitative, descriptive study performed through document analysis and application of a semi-structured questionnaire to oral health coordinators, in 2014. The following items were defined: dental infrastructure, access and regulation, work organization and assessment strategies. Although the Basic Health Unit is the main gateway to the system, dental care was also conducted in schools; the main service access of the population was the spontaneous demand and there have been production data inconsistencies in the information systems. Results: It was observed that, 60% answered that the health planning process included oral health; 47.5% performed risk assessment; 47.5% did not perform evaluation and monitoring of results. Conclusion: It is concluded that municipalities present different moments in the structuring of the service and that managers should improve the access organization, the work process and service evaluation in order to consolidate the universality and comprehensiveness of health care.
DOI: 10.6084/m9.figshare.14268831.v1
title: Risk factors for diarrhea occurrence in children living in Guaratiba Island (RJ)

description: ABSTRACT This article aimed to analyze the occurrence of acute diarrhea in children under five years old assisted by the Family Health Strategy of Guaratiba Island, and housing and sanitation conditions of the locality. A cross-sectional epidemiological study was carried out. The analysis of the variables was made by using simple and multiple logistic regression. The variables that showed association with diarrhea were: (a) children &lt;2,5 years old; attend daycare/school and family income
DOI: 10.6084/m9.figshare.14268831
title: Risk factors for diarrhea occurrence in children living in Guaratiba Island (RJ)

description: ABSTRACT This article aimed to analyze the occurrence of acute diarrhea in children under five years old assisted by the Family Health Strategy of Guaratiba Island, and housing and sanitation conditions of the locality. A cross-sectional epidemiological study was carried out. The analysis of the variables was made by using simple and multiple logistic regression. The variables that showed association with diarrhea were: (a) children &lt;2,5 years old; attend daycare/school and family income