cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.5061/dryad.rr4xgxd87
title: Data from: Genetic variation in reproductive investment across an Ephemerality gradient in Daphnia pulex

description: Species across the tree of life can switch between asexual and sexual
 reproduction. In facultatively sexual species, the ability to switch
 between reproductive modes is often environmentally dependent and subject
 to local adaptation. However, the ecological and evolutionary factors that
 influence the maintenance and turnover of polymorphism associated with
 facultative sex remain unclear. We studied the ecological and evolutionary
 dynamics of reproductive investment in the facultatively sexual model
 species, Daphnia pulex. We found that patterns of clonal diversity, but
 not genetic diversity varied among ponds consistent with the predicted
 relationship between ephemerality and clonal structure. Reconstruction of
 a multi-year pedigree demonstrated the coexistence of clones that differ
 in their investment into male production. Mapping of quantitative
 variation in male production using lab-generated and field-collected
 individuals identified multiple putative quantitative trait loci (QTL)
 underlying this trait, and we identified a plausible candidate gene. The
 evolutionary history of these QTL suggests that they are relatively young,
 and male limitation in this system is a rapidly evolving trait. Our work
 highlights the dynamic nature of the genetic structure and composition of
 facultative sex across space and time and suggests that quantitative
 genetic variation in reproductive strategy can undergo rapid evolutionary
 turnover.
description: Multiple phenotyping files related to sexual investment in
 Daphnia. Multiple files related to whole genome sequencing
 analysis.
DOI: 10.6084/m9.figshare.31165634
title: Additional file 1 of Tannic acid inhibits TNF-α signaling by targeting the protein disulfide isomerase and alleviates symptoms in an imiquimod-induced psoriasis mouse model

description: Supplementary Material 1
DOI: 10.6084/m9.figshare.31165634.v1
title: Additional file 1 of Tannic acid inhibits TNF-α signaling by targeting the protein disulfide isomerase and alleviates symptoms in an imiquimod-induced psoriasis mouse model

description: Supplementary Material 1
DOI: 10.5061/dryad.2547d7wqj
title: Asellus aquaticus genome and VCF file from samples obtained on Gotland, Sweden

description: Organisms well suited for the study of ecotype formation have wide
 distribution ranges, where they adapt to multiple drastically different
 habitats repeatedly over space and time. Here we study such ecotypes in a
 Crustacean model, Asellus aquaticus, a commonly occurring isopod
 found in freshwater habitats as diverse as streams, caves and lakes.
 Previous studies focusing on cave versus surface
 ecotypes have attributed depigmentation, eye loss and prolonged antennae
 to several south European cave systems. Likewise, surveys across multiple
 Swedish lakes have identified the presence of dark-pigmented
 "reed" and light-pigmented "stonewort" ecotypes, which
 can be found within the same lake. In this study, we sequenced the first
 draft genome of A. aquaticus, and subsequently use this to map
 reads and call variants in surface stream, cave and two lake ecotypes. In
 addition, the draft genome was combined with a RADseq approach to perform
 a QTL mapping study using a laboratory bred F2 and
 F4 cave x surface intercross. We identified genomic regions
 associated with body pigmentation, antennae length and body size.
 Furthermore, we compared genome-wide differentiation between natural
 populations and found several genes potentially associated to these
 habitats. The assessment of the cave QTL regions in the light-dark
 comparison of lake populations suggests that the regions associated with
 cave adaptation are also involved with genomic differentiation in the lake
 ecotypes. These demonstrate how troglomorphic adaptations can be used as a
 model for related ecotype formation.
description: An Asellus aquaticus population from Lummelunda Cave on Gotland,
 Sweden was collected in 2014 and has been reared in the laboratory of
 Linkoping University until 2021. Genomic DNA from a single female specimen
 from this inbred population was extracted using standard salt-based DNA
 extraction method and sequenced on a single S4 lane of an Illumina NovaSeq
 6000 machine. 10xGenomics linked read libraries were prepared from the
 genomics DNA prior to sequencing (outsourced to SciLife Labs.,
 Sweden).  The genome assembly was conducted using SUPERNOVA software and
 was subsequently scaffolded using paired end WGS data from two other
 Asellus aquaticus samples collected in the same area. Important note!: As
 part of our study we screened only scaffolds that we analysed for
 contamination. Therefore, this raw genome build is bound to have
 contamination sequences in it. Keep this in mind and apply
 de-contamination pipelines if necessary. The VCF file
 includes over 6 million SNPs and was derived from natural populations
 (LU-Lummelunda Upstream, LC-Lummelunda Cave, LD-Lummelunda Downstream,
 HR-Horsan Reed, HS-Horsan Stony bottom) and from F2 and F4 populations
 derived from a cave x surface intercross. Most of the present SNP variants
 are poorly represented among the samples (around 1000-2000 SNPs are better
 represented).
DOI: 10.5061/dryad.jh9w0vtbm
title: Site-specific impacts of a major hurricane on alpha and beta diversity in tropical forest seedling communities

description: Large scale disturbances are known to impact the alpha and beta diversity
 of communities. However, whether these disturbances increase or decrease
 diversity is often debated. The goal of this study was to quantify how the
 diversity of the seedling community was impacted within and across
 elevation in the El Yunque forest of Puerto Rico following a major
 hurricane. We tested two alternative hypotheses, that hurricanes are
 relatively more homogenizing or non-homogenizing forces, by quantifying
 changes in alpha and beta diversity of the seedling community
 post-hurricane. This approach highlights whether ecological mechanisms
 associated with community homogenization (species-specific survival,
 successional processes, and reduced environmental heterogeneity) or
 non-homogenization (resource release, increased environmental
 heterogeneity, and stochastic processes) structure the seedling community
 post-hurricane. We compared species richness, Fisher’s α, Simpson’s
 evenness, and multiple aspects of beta diversity within and among 25
 seedling plots at 300, 400, and 500 m in elevation pre- and
 post-hurricane. We found that species richness, diversity, and evenness
 were higher post-hurricane, but abundance decreased 19%. Increases in
 alpha diversity suggest that hurricanes are non-homogenizing forces
 potentially linked with increases in light levels promoting colonization
 of early-successional species and resource release for other
 light-demanding species. The beta diversity results varied in their
 support for hurricanes as homogenizing depending upon the spatial scale of
 the analysis, potentially due to a combination of mechanisms including
 species-specific survival and site-specific differences. To fully grasp
 how the seedling community responds and recovers from disturbance,
 additional long-term monitoring will be needed to allow insight into the
 future of species richness, abundance, and spatial and temporal changes in
 community composition.
DOI: 10.25349/d9jc8b
title: Imaging orbital ferromagnetism in a moire Chern insulator

description: Electrons in moire flat band systems can spontaneously break time reversal
 symmetry, giving rise to a quantized anomalous Hall effect. Here we use a
 superconducting quantum interference device to image stray magnetic fields
 in twisted bilayer graphene aligned to hexagonal boron nitride. We find
 a magnetization of several Bohr magnetons per charge carrier,
 demonstrating that the magnetism is primarily orbital in nature. Our
 measurements reveal a large change in the magnetization as the chemical
 potential is swept across the quantum anomalous Hall gap consistent with
 the expected contribution of chiral edge states to the magnetization of an
 orbital Chern insulator. Mapping the spatial evolution of field-driven
 magnetic reversal, we find a series of reproducible micron scale domains,
 pinned to structural disorder.  
description: This dataset contains scanning SQUID measurements and electronic
 transport measurements of a twisted bilayer graphene sample supporting an
 orbital Chern magnet phase.  The scanning SQUID measurements were
 collected using a cryogenic nanoSQUID microscope.  
description: Relevant metadata is included in the plotting scripts and
 described in context.
DOI: 10.6084/m9.figshare.31165643
title: Additional file 1 of Association between serum osmolality trajectories and mortality in sepsis patients: a retrospective multi-cohort study

description: Supplementary material 1.
DOI: 10.6084/m9.figshare.31165643.v1
title: Additional file 1 of Association between serum osmolality trajectories and mortality in sepsis patients: a retrospective multi-cohort study

description: Supplementary material 1.
DOI: 10.6084/m9.figshare.31165649
title: Additional file 2 of Association between serum osmolality trajectories and mortality in sepsis patients: a retrospective multi-cohort study

description: Supplementary material 2.
DOI: 10.6084/m9.figshare.31165649.v1
title: Additional file 2 of Association between serum osmolality trajectories and mortality in sepsis patients: a retrospective multi-cohort study

description: Supplementary material 2.
DOI: 10.6084/m9.figshare.31165652
title: Additional file 3 of Association between serum osmolality trajectories and mortality in sepsis patients: a retrospective multi-cohort study

description: Supplementary material 3.
DOI: 10.6084/m9.figshare.31165652.v1
title: Additional file 3 of Association between serum osmolality trajectories and mortality in sepsis patients: a retrospective multi-cohort study

description: Supplementary material 3.
DOI: 10.5061/dryad.612jm643c
title: Genomic analysis reveals a polygenic architecture of antler morphology in wild red deer (Cervus elaphus)

description: Sexually-selected traits show large variation and rapid evolution across
 the animal kingdom, yet genetic variation often persists within
 populations despite apparent directional selection. A key step in solving
 this long-standing paradox is to determine the genetic architecture of
 sexually-selected traits to understand evolutionary drivers and
 constraints at the genomic level. Antlers are a form of sexual weaponry in
 male red deer. On the island of Rum, Scotland, males with larger antlers
 have increased breeding success, yet there has been no evidence of any
 response to selection at the genetic level. To try and understand the
 mechanisms underlying this observation, we investigate the genetic
 architecture of ten antler traits and their principal components using
 genomic data from &gt;38,000 SNPs. We estimate the heritabilities and
 genetic correlations of the antler traits using a genomic relatedness
 approach. We then use genome-wide association and haplotype-based regional
 heritability to identify regions of the genome underlying antler
 morphology, and an Empirical Bayes approach to estimate the underlying
 distributions of allele effect sizes. We show that antler morphology is
 highly repeatable over an individual's lifetime, heritable, and has a
 polygenic architecture, and that almost all antler traits are positively
 genetically correlated with some loci identified as having pleiotropic
 effects. Our findings suggest that a large mutational target and genetic
 covariances among antler traits, in part maintained by pleiotropy, are
 likely to contribute to the maintenance of genetic variation in antler
 morphology in this population.
description: See preprint on bioRxiv "Genomic analysis reveals a
 polygenic architecture of antler morphology in wild red deer (Cervus
 elaphus)"
DOI: 10.6084/m9.figshare.31165655
title: Additional file 4 of Association between serum osmolality trajectories and mortality in sepsis patients: a retrospective multi-cohort study

description: Supplementary material 4.
DOI: 10.6084/m9.figshare.31165655.v1
title: Additional file 4 of Association between serum osmolality trajectories and mortality in sepsis patients: a retrospective multi-cohort study

description: Supplementary material 4.
DOI: 10.5061/dryad.8sf7m0cn7
title: Influence of a university cooperation on the development of interprofessional competences

description: Objectives This project carried out in cooperation between the University
 of Applied Sciences for Health Professions Upper Austria (UASHPUA) and the
 Medical Faculty of Johannes Kepler University Linz (MFJKUL), describes the
 feasibility, i.e., the planning and implementation, and presents selected
 results of an inter-university lecture on interprofessional cooperation.
 Methodology The lecture “Grundlagen zu interprofessioneller Zusammenarbeit
 im Gesundheitswesen (IPZ3I)” / “Introduction to interprofessional
 cooperation in health care (IPZ3I)”) as well as an interprofessional job
 shadowing were designed. The pilot lecture started in the winter semester
 (WS) 2019/20. An evaluation of IPZ3I was undertaken by means of a
 questionnaire.  Results IPZ3I was held in WS 2019/20 for 296
 students from nine different health care professions and included a
 specialist lecture, the presentation of the professions, and
 interprofessional case processing. In the evaluation approx. 80 % of the
 students described a better understanding of the interprofessional
 collaboration. More than 70 % regard interprofessional courses in
 education as important or very important. The majority of respondents
 indicate that after completing the lecture they can make recommendations
 for action for interprofessional cooperation. Conclusions The joint
 lecture IPZ3I will be maintained at both universities. The process of
 evaluation and adaptation of curricula at UASHPUA is currently underway.
 This includes, for instance, consultations with the curriculum officers at
 MFJKUL, and the exploration of further possibilities to identify and to
 implement joint interprofessional teaching aspects in the curricula. This
 shall be achieved by considering the existing resources, increasing
 student numbers at MFJKUL as of 2023, planned curricula revisions as well
 as using possible synergies aiming at an extension of the existing
 cooperation. Key words Interprofessionalism; project description;
 curriculum development; competency-based education
description:  questionnaire
DOI: 10.5061/dryad.c866t1g6r
title: DatasetS2 Intramidbrain macroconnection reports for rat

description: This file contains data used to construct connection matrices for network
 analysis of the rat intra-midbrain axonal connections from one gray matter
 region to another. The data was expertly collated from the peer-reviewed
 neuroanatomical literature. The Connection Reports are listed in an Excel
 Worksheet and are self-explanatory. 
description: This data was expertly collated from the peer reviewed literature
 and then subjected to standard network analysis.
DOI: 10.5061/dryad.r4xgxd2cg
title: The earliest example of sexual dimorphism in bivalves – evidence from the astartid Nicaniella (Lower Jurassic, Southern Germany)

description: Protandrous sex change (sex change from male to female) is one of the
 diverse sexual expressions exhibited by bivalves, but its expression in
 the shell is quite rare. Previous studies on living and fossil astartids
 suggest a relationship between protandrous sex change and the formation of
 crenulations on the ventral shell margin at later ontogenetic stages. Here
 we report the formation of such crenulations in the Early Jurassic
 astartid Nicaniella rakoveci (Kuhn, 1935) from the Amaltheenton Formation
 at Buttenheim, Franconia. This is the earliest known record of protandrous
 hermaphroditism in fossil bivalves, predating previous reports by at least
 13 Myr. A principal component analysis of linear size measurements and
 Fourier shape analysis of the shell outlines revealed that the outline of
 Nicaniella rakoveci specimens varies from subquadrate to subcircular, but
 this variation is independent of the presence or absence of crenulations
 and therefore not associated with sex. Crenulated specimens exhibit a
 lower height/inflation ratio than non-crenulated ones, suggesting that the
 protandrous females have more inflated valves than the males. The
 formation of crenulations was probably related to allocation of resources
 for reproduction. The most likely function of the crenulations was to
 increase the internal shell volume in the female stage to accommodate more
 eggs rather than being an adaptation against predation as often assumed
 for other bivalves. The formation of crenulations is part of the
 protandrous life history and probably controlled by a genetic mechanism
 that is also responsible for sex change.
DOI: 10.5061/dryad.3n5tb2rhh
title: A common endocrine signature marks convergent evolution of an elaborate dance display in frogs

description: Unrelated species often evolve similar phenotypic solutions to the same
 environmental problem, a phenomenon known as convergent evolution. But,
 how do these ‘common traits’ arise? We address this question from a
 physiological perspective by assessing how convergence of an elaborate
 gestural display in frogs (“foot flagging”) is linked to changes in the
 androgenic hormone systems that underlie it. We show that the emergence of
 this rare display in unrelated anuran taxa is marked by a robust increase
 in the expression of androgen receptor (AR) mRNA in the musculature that
 actuates leg and foot movements, but we find no evidence of changes in
 abundance of AR expression in these frogs’ central nervous system (CNS).
 Meanwhile, the magnitude of the evolutionary change in muscular AR and its
 association with the origin of foot flagging differ among clades,
 suggesting that these variables evolve together in a mosaic fashion.
 Finally, while gestural displays do differ between species, variation in
 the complexity of a foot-flag routine does not predict differences in
 muscular AR. Altogether, these findings suggest that androgen-muscle
 interactions provide a conduit for convergence in sexual display behavior,
 potentially providing a ‘path of least resistance’ for the evolution of
 motor performance.
DOI: 10.5061/dryad.zw3r2287s
title: Small mammals and their environment in Romania

description: The dataset contains the results of surveys on small mammal communities
 conducted in various habitat types across Romania, starting with 2000.
 Location of sampling sites, habitat characteristics, trapping effort and
 the number of individuals captured as well as the capture
 index for each species are given.
description: We live-trapped small mammals using artisanal wooden box-traps
 (18 x 10 x 8 cm) or Fitch traps (40 x 6 x 6) set in transects (trap-lines)
 or grids, mostly during the warm season. Transects included 30 to 40 traps
 set 15 m apart along the contour lines and parallel to the closest
 watercourse, forest edge, road or trail, within homogenous forest
 habitats; ecotones were avoided. Trapping grids included between 6 x 4 and
 8 x 8 traps at distances of 10 or 15 m.  Traps were
 baited with sunflower seeds and apple slices, but no prebaiting was done.
 Traps were checked in the morning and at dusk for two or three consecutive
 days. Because many traps were disturbed by weather, animals or people, the
 trapping effort differed greatly among transects. We
 identified captured individuals to species based on morphological traits,
 marked them by fur clipping, and then released each at its trapping site.
 Recaptures were not included in the dataset. For each
 transect or grid we estimated a series of habitat variables generally
 considered to be important for small mammal populations: percent cover of
 tree canopy (referred to as tree cover hereafter) also recorded separately
 for coniferous trees, percent of shrub and herbaceous layers, mean height
 (cm) of herbaceous layer, distance (m) to closest watercourse, river or
 creek, and elevation (m). Tree cover was estimated by the percent of the
 ground where light fell directly; distance to water and elevation were
 measured for the trap placed at the center point of the transect. Soil
 moisture, abundance of rocks, coarse woody debris and human disturbance
 were estimated as ordinal variables.  Additional
 details on the variables are given separately for each subset of the
 dataset in the corresponding read.me files. <br>
DOI: 10.5061/dryad.kwh70rz3q
title: Data from: Distinct developmental mechanisms influence sexual dimorphisms in the milkweed bug Oncopeltus fasciatus

description: Sexual dimorphism is common in animals. The most complete model of sex
 determination comes from Drosophila melanogaster, where the relative
 dosage of autosomes and X chromosomes leads indirectly to sex-specific
 transcripts of doublesex (dsx). Female Dsx interacts with a mediator
 complex protein encoded by intersex to activate female development. In
 males the transcription factor encoded by fruitless promotes male-specific
 behavior. The genetics of sex determination have been examined in a small
 number of other insects, yet several questions remain about the
 plesiomorphic state. Is doublesex required for female and male
 development? Is fruitless conserved in male behavior or morphology? Are
 other components such as intersex functionally conserved? To address these
 questions, we report the expression and functional tests of doublesex,
 intersex and fruitless in the hemipteran Oncopeltus fasciatus,
 characterizing three sexual dimorphisms. doublesex prevents intersex
 phenotypes in all sexes and dimorphic traits in the milkweed bug. intersex
 and fruitless are expressed across the body, in females and males.
 fruitless and intersex also affect the genitalia of both sexes but have
 effects limited to different dimorphic structures in different sexes.
 These results reveal roles for intersex and fruitless distinct from other
 insects and demonstrate distinct development mechanisms in different
 sexually dimorphic structures.
description: This publication contains amino acid alignments produced using
 ClustalW, protein trees produced using maximum likelihood, linear
 morphological measurements, 2D landmark  coordinates for morphology and
 the associated analysis code, as well as gene expression values.