cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.7773158
title: Mechanical and optical properties of conventional restorative glass-ionomer cements - a systematic review

description: Abstract Objectives To perform a systematic review of test methodologies on conventional restorative glass-ionomer cement (GIC) materials for mechanical and optical properties to compare the results between different GICs. Material and Methods Screening of titles and abstracts, data extraction, and quality assessments of full-texts were conducted in search for in vitro studies on conventional GICs that follow the relevant specifications of ISO standards regarding the following mechanical and optical properties: compressive strength, flexural strength, color, opacity and radiopacity. Sources The Latin American and Caribbean Health Sciences (LILACS), Brazilian Bibliography of Dentistry (BBO) databases from Latin-American and Caribbean System on Health Sciences Information (BIREME) and PubMed/Medline (US National Library of Medicine - National Institutes of Health) databases were searched regardless of language. Altogether, 1146 in vitro studies were selected. Two reviewers independently selected and assessed the articles according to pre-established inclusion/exclusion criteria. Among all the properties investigated, only one study was classified as being of fair quality that tested compressive strength and was included. It was observed that many authors had not strictly followed ISO recommendations and that, for some properties (diametral tensile strength and microhardness), there are no guidelines provided. Conclusions It was not possible to compare the results for the mechanical and optical properties of conventional restorative GICs due to the lack of standardization of studies.
DOI: 10.6084/m9.figshare.7773152
title: Taste and flavor in food experience: conceptual reflections (abstract: p. 7)

description: The present paper addresses the use and definition of terms from the field of sensory perceptions of foods to suggest a more accurate usage of this terminology in clinical practice and scientific categorization. The starting point of the discussion was recent findings in the area of neuroscience that contributed to the mentioned field and a retrospective examination of studies relevant to the subject. From the concepts defined by the terms in English “taste” and “flavor” (or “flavour”), correspondences with Portuguese words were obtained, so that the terminology can represent the connection between sense organs and the brain in food sensory perception.
DOI: 10.6084/m9.figshare.7773158.v1
title: Mechanical and optical properties of conventional restorative glass-ionomer cements - a systematic review

description: Abstract Objectives To perform a systematic review of test methodologies on conventional restorative glass-ionomer cement (GIC) materials for mechanical and optical properties to compare the results between different GICs. Material and Methods Screening of titles and abstracts, data extraction, and quality assessments of full-texts were conducted in search for in vitro studies on conventional GICs that follow the relevant specifications of ISO standards regarding the following mechanical and optical properties: compressive strength, flexural strength, color, opacity and radiopacity. Sources The Latin American and Caribbean Health Sciences (LILACS), Brazilian Bibliography of Dentistry (BBO) databases from Latin-American and Caribbean System on Health Sciences Information (BIREME) and PubMed/Medline (US National Library of Medicine - National Institutes of Health) databases were searched regardless of language. Altogether, 1146 in vitro studies were selected. Two reviewers independently selected and assessed the articles according to pre-established inclusion/exclusion criteria. Among all the properties investigated, only one study was classified as being of fair quality that tested compressive strength and was included. It was observed that many authors had not strictly followed ISO recommendations and that, for some properties (diametral tensile strength and microhardness), there are no guidelines provided. Conclusions It was not possible to compare the results for the mechanical and optical properties of conventional restorative GICs due to the lack of standardization of studies.
DOI: 10.6084/m9.figshare.7773152.v1
title: Taste and flavor in food experience: conceptual reflections (abstract: p. 7)

description: The present paper addresses the use and definition of terms from the field of sensory perceptions of foods to suggest a more accurate usage of this terminology in clinical practice and scientific categorization. The starting point of the discussion was recent findings in the area of neuroscience that contributed to the mentioned field and a retrospective examination of studies relevant to the subject. From the concepts defined by the terms in English “taste” and “flavor” (or “flavour”), correspondences with Portuguese words were obtained, so that the terminology can represent the connection between sense organs and the brain in food sensory perception.
DOI: 10.6084/m9.figshare.7773125
title: THE SEARCH FOR LEAD AND SILVER IN MINAS GERAIS AS ALTERNATIVES TO THE DEPLETED GOLD AND DIAMOND MINES ALONG THE NINETEENTH CENTURY

description: At the turn of the nineteenth century, a frantic search took place in Minas Gerais for minerals that could prove to be of economic value and thus compensate for the decline in the production of gold and diamonds, the mainstay of the economy in the preceding century. This article addresses the search for new mineral wealth, involving the work of many different explorers and their multidisciplinary research, and particularly the unsuccessful efforts directed to finding and obtaining lead and silver in sizable amounts as two such possible replacements.
DOI: 10.6084/m9.figshare.7773122
title: RECENT ADVANCES IN COMBINATORIAL BIOSYNTHESIS OF POLYKETIDES: PERSPECTIVES AND CHALLENGES

description: Natural products continue to inspire scientists on the search for biological active structures. Recent advances in synthetic biology allow modifying genes to extend structural diversity present on natural products by changing important functional groups guided through genetic information. In this context, polyketides synthases (PKS) represent a class of enzymes from where the first applications and well succeed modifications were achieved. During the last two decades PKSs have been extensively studied, sequenced and deposited in data banks available to scientific community around the world. This newly wide information associated to different methodologies accessible to modify the PKSs genetic circuits including genetic insertion, gene deletion and gene replacement leads to discovery of new natural products. In this review, the recent advances in combinatorial biosynthesis, as well as modern techniques in synthetic biology to promote structural diversity on natural products will be discussed.
DOI: 10.6084/m9.figshare.7773125.v1
title: THE SEARCH FOR LEAD AND SILVER IN MINAS GERAIS AS ALTERNATIVES TO THE DEPLETED GOLD AND DIAMOND MINES ALONG THE NINETEENTH CENTURY

description: At the turn of the nineteenth century, a frantic search took place in Minas Gerais for minerals that could prove to be of economic value and thus compensate for the decline in the production of gold and diamonds, the mainstay of the economy in the preceding century. This article addresses the search for new mineral wealth, involving the work of many different explorers and their multidisciplinary research, and particularly the unsuccessful efforts directed to finding and obtaining lead and silver in sizable amounts as two such possible replacements.
DOI: 10.6084/m9.figshare.7773119
title: Population aging and health spending: an analysis of intergenerational and intragenerational transfers in the Brazilian private health care plans

description: Abstract The health insurance pricing model in Brazil prohibits large variations of monthly fees by imposing strict premium rules by age. Therefore, intergenerational transfers may occur from younger age groups, who are lower-risk, to older ones. Population aging will result in a larger share of policyholders at older ages, increasing intergenerational transfers and making the current pricing structure unsustainable in the future. The aim of this article is to estimate the magnitude of intergenerational and intragenerational transfers (within the same age group) in the Brazilian private health care plans, by examining data from a representative sample of health insurance providers. We found intergenerational transfers to occur, on average, from policy holders younger than 66 years of age to older ones. Results also show significant intragenerational transfers within two of the age groups defined by existing legislation: 0 to 18 and 59 years and older. Finally, simulations using changes in the age structure over the last 15 years confirm population aging may result in larger intergenerational transfers with increasing loss-ratio over time.
DOI: 10.6084/m9.figshare.7773122.v1
title: RECENT ADVANCES IN COMBINATORIAL BIOSYNTHESIS OF POLYKETIDES: PERSPECTIVES AND CHALLENGES

description: Natural products continue to inspire scientists on the search for biological active structures. Recent advances in synthetic biology allow modifying genes to extend structural diversity present on natural products by changing important functional groups guided through genetic information. In this context, polyketides synthases (PKS) represent a class of enzymes from where the first applications and well succeed modifications were achieved. During the last two decades PKSs have been extensively studied, sequenced and deposited in data banks available to scientific community around the world. This newly wide information associated to different methodologies accessible to modify the PKSs genetic circuits including genetic insertion, gene deletion and gene replacement leads to discovery of new natural products. In this review, the recent advances in combinatorial biosynthesis, as well as modern techniques in synthetic biology to promote structural diversity on natural products will be discussed.
DOI: 10.6084/m9.figshare.7773116
title: Is interim 18F-fluoride PET/CT a predictor of outcomes after radium-223 therapy?

description: Abstract Objective: To determine whether an interim 18F-fluoride positron-emission tomography/computed tomography (PET/CT) study performed after the third cycle of radium-223 dichloride (223RaCl2) therapy is able to identify patients that will not respond to treatment. Materials and Methods: We retrospectively reviewed 34 histologically confirmed cases of hormone-refractory prostate cancer with bone metastasis in patients submitted to 223RaCl2 therapy. All of the patients underwent baseline and interim 18F-fluoride PET/CT studies. The interim study was performed immediately prior to the fourth cycle of 223RaCl2. The skeletal tumor burden-expressed as the total lesion fluoride uptake above a maximum standardized uptake value of 10 (TLF10)-was calculated for the baseline and the interim studies. The percent change in TLF10 between the baseline and interim studies (%TFL10) was calculated as follows: %TFL10 = interim TLF10 - baseline TLF10 / baseline TLF10. End points were overall survival, progression-free survival, and skeletal-related events. Results: The mean age of the patients was 72.4 ± 10.2 years (range, 43.3-88.8 years). The %TLF10 was not able to predict overall survival (p = 0.6320; hazard ratio [HR] = 0.753; 95% confidence interval [CI]: 0.236-2.401), progression-free survival (p = 0.5908; HR = 1.248; 95% CI: 0.557-2.797) nor time to a bone event (p = 0.5114; HR = 1.588; 95% CI: 0.399-6.312). Conclusion: The skeletal tumor burden on an interim 18F-fluoride PET/CT, performed after three cycles of 223RaCl2, is not able to predict overall survival, progression-free survival, or time to bone event, and should not be performed to monitor response at this time.
DOI: 10.6084/m9.figshare.7773119.v1
title: Population aging and health spending: an analysis of intergenerational and intragenerational transfers in the Brazilian private health care plans

description: Abstract The health insurance pricing model in Brazil prohibits large variations of monthly fees by imposing strict premium rules by age. Therefore, intergenerational transfers may occur from younger age groups, who are lower-risk, to older ones. Population aging will result in a larger share of policyholders at older ages, increasing intergenerational transfers and making the current pricing structure unsustainable in the future. The aim of this article is to estimate the magnitude of intergenerational and intragenerational transfers (within the same age group) in the Brazilian private health care plans, by examining data from a representative sample of health insurance providers. We found intergenerational transfers to occur, on average, from policy holders younger than 66 years of age to older ones. Results also show significant intragenerational transfers within two of the age groups defined by existing legislation: 0 to 18 and 59 years and older. Finally, simulations using changes in the age structure over the last 15 years confirm population aging may result in larger intergenerational transfers with increasing loss-ratio over time.
DOI: 10.6084/m9.figshare.7773104
title: Visual and automatic classification of the cyclic alternating pattern in electroencephalography during sleep

description: Cyclic alternating pattern (CAP) is a neurophysiological pattern that can be visually scored by international criteria. The aim of this study was to verify the feasibility of visual CAP scoring using only one channel of sleep electroencephalogram (EEG) to evaluate the inter-scorer agreement in a variety of recordings, and to compare agreement between visual scoring and automatic scoring systems. Sixteen hours of single-channel European data format recordings from four different sleep laboratories with either C4-A1 or C3-A2 channels and with different sampling frequencies were used in this study. Seven independent scorers applied visual scoring according to international criteria. Two automatic blind scorings were also evaluated. Event-based inter-scorer agreement analysis was performed. The pairwise inter-scorer agreement (PWISA) was between 55.5 and 84.3%. The average PWISA was above 60% for all scorers and the global average was 69.9%. Automatic scoring systems showed similar results to those of visual scoring. The study showed that CAP could be scored using only one EEG channel. Therefore, CAP scoring might also be integrated in sleep scoring features and automatic scoring systems having similar performances to visual sleep scoring systems.
DOI: 10.6084/m9.figshare.7773107
title: Long-Term Traumatic and Asymptomatic Aorto-Right Atrial Fistula

description: Abstract Aorto-atrial fistulas due to cardiac trauma are rare, and survivors require immediate surgical correction. Here, we report a case of an aorto-right atrial fistula due to penetrating trauma after a 16-year evolution, which developed symptoms of acute coronary syndrome and was treated with myocardial revascularization and correction of the aorto-cameral fistula.
DOI: 10.6084/m9.figshare.7773110
title: Temporomandibular joint disc displacement with reduction: a review of mechanisms and clinical presentation

description: Abstract Disc displacement with reduction (DDWR) is one of the most common intra-articular disorders of the temporomandibular joint (TMJ). Factors related to the etiology, progression and treatment of such condition is still a subject of discussion. This literature review aimed to address etiology, development, related factors, diagnosis, natural course, and treatment of DDWR. A non-systematic search was conducted within PubMed, Scopus, SciELO, Medline, LILACS and Science Direct using the Medical Subjective Headings (MeSH) terms “temporomandibular disorders”, “temporomandibular joint”, “disc displacement” and “disc displacement with reduction”. No time restriction was applied. Literature reviews, systematic reviews, meta-analysis and clinical trials were included. DDWR is usually asymptomatic and requires no treatment, since the TMJ structures adapt very well and painlessly to different disc positions. Yet, long-term studies have shown the favorable progression of this condition, with no pain and/or jaw locking occurring in most of the patients.
DOI: 10.6084/m9.figshare.7773116.v1
title: Is interim 18F-fluoride PET/CT a predictor of outcomes after radium-223 therapy?

description: Abstract Objective: To determine whether an interim 18F-fluoride positron-emission tomography/computed tomography (PET/CT) study performed after the third cycle of radium-223 dichloride (223RaCl2) therapy is able to identify patients that will not respond to treatment. Materials and Methods: We retrospectively reviewed 34 histologically confirmed cases of hormone-refractory prostate cancer with bone metastasis in patients submitted to 223RaCl2 therapy. All of the patients underwent baseline and interim 18F-fluoride PET/CT studies. The interim study was performed immediately prior to the fourth cycle of 223RaCl2. The skeletal tumor burden-expressed as the total lesion fluoride uptake above a maximum standardized uptake value of 10 (TLF10)-was calculated for the baseline and the interim studies. The percent change in TLF10 between the baseline and interim studies (%TFL10) was calculated as follows: %TFL10 = interim TLF10 - baseline TLF10 / baseline TLF10. End points were overall survival, progression-free survival, and skeletal-related events. Results: The mean age of the patients was 72.4 ± 10.2 years (range, 43.3-88.8 years). The %TLF10 was not able to predict overall survival (p = 0.6320; hazard ratio [HR] = 0.753; 95% confidence interval [CI]: 0.236-2.401), progression-free survival (p = 0.5908; HR = 1.248; 95% CI: 0.557-2.797) nor time to a bone event (p = 0.5114; HR = 1.588; 95% CI: 0.399-6.312). Conclusion: The skeletal tumor burden on an interim 18F-fluoride PET/CT, performed after three cycles of 223RaCl2, is not able to predict overall survival, progression-free survival, or time to bone event, and should not be performed to monitor response at this time.
DOI: 10.6084/m9.figshare.7773101
title: DEGREE OF SATISFACTION WITH THE ENDOSCOPIC TREATMENT OF LUMBAR DISC HERNIATION

description: ABSTRACT Objective: To evaluate the degree of patient satisfaction and complications after endoscopic surgery for the treatment of lumbar disc herniation. Methods: We retrospectively evaluated 94 patients with lumbar disc herniation undergoing endoscopic lumbar discectomy through the MacNab questionnaire and four subjective questions related to the procedure. Results: Approximately 82% of the patients had good and excellent results, and 91.4% reported being satisfied with the surgical result obtained with endoscopy. The rate of complications with the method was 9.5%, with recurrent disc herniation being the most common complication (5.4% of cases). Conclusions: Endoscopic surgery proved to be an effective and safe method, and an alternative to conventional open surgery. Level of evidence; III. Therapeutic studies - Investigation of treatment results.
DOI: 10.6084/m9.figshare.7773104.v1
title: Visual and automatic classification of the cyclic alternating pattern in electroencephalography during sleep

description: Cyclic alternating pattern (CAP) is a neurophysiological pattern that can be visually scored by international criteria. The aim of this study was to verify the feasibility of visual CAP scoring using only one channel of sleep electroencephalogram (EEG) to evaluate the inter-scorer agreement in a variety of recordings, and to compare agreement between visual scoring and automatic scoring systems. Sixteen hours of single-channel European data format recordings from four different sleep laboratories with either C4-A1 or C3-A2 channels and with different sampling frequencies were used in this study. Seven independent scorers applied visual scoring according to international criteria. Two automatic blind scorings were also evaluated. Event-based inter-scorer agreement analysis was performed. The pairwise inter-scorer agreement (PWISA) was between 55.5 and 84.3%. The average PWISA was above 60% for all scorers and the global average was 69.9%. Automatic scoring systems showed similar results to those of visual scoring. The study showed that CAP could be scored using only one EEG channel. Therefore, CAP scoring might also be integrated in sleep scoring features and automatic scoring systems having similar performances to visual sleep scoring systems.
DOI: 10.6084/m9.figshare.7773107.v1
title: Long-Term Traumatic and Asymptomatic Aorto-Right Atrial Fistula

description: Abstract Aorto-atrial fistulas due to cardiac trauma are rare, and survivors require immediate surgical correction. Here, we report a case of an aorto-right atrial fistula due to penetrating trauma after a 16-year evolution, which developed symptoms of acute coronary syndrome and was treated with myocardial revascularization and correction of the aorto-cameral fistula.
DOI: 10.6084/m9.figshare.7773098
title: IMPACT OF THE MIS-TLIF TECHNIQUE ON THE SPINOPELVIC PARAMETERS OF PATIENTS WITH LUMBAR ARTHRODESIS

description: ABSTRACT Objective: To evaluate the influence of the MIS-TLIF technique on the spinopelvic parameters of patients submitted to lumbar arthrodesis up to three levels for the treatment of vertebral degenerative conditions without deformity. Methods: Retrospective radiographic evaluation of 52 patients submitted to the surgical treatment of lumbar arthrodesis using the MIS-TLIF technique in up to three levels. The spinopelvic parameters – pelvic incidence (PI), pelvic tilt(PT), lumbar lordosis (LL), segmental lordosis (Lseg), and the difference between lumbar lordosis and pelvic incidence (LL-PI mismatch) were analyzed in orthostatic lateral radiographs in the pre- and postoperative periods, with a minimum follow-up of 1 year. The patients were divided into three groups: PI &lt;45°, PI between 45° and 55° and PI &gt;55°. Results: Sixty-nine operated levels were evaluated in 15 patients with PI &lt;45°, 19 with PI between 45° and 55° and 18 with PI &gt;55°. The mean value of the pelvic incidence was 52.3° (± 11.5), lumbar lordosis 46.1° (pre)/45.6° (post); segmental lordosis 20.3° (pre)/20.6° (post); pelvic tilt 18.5° (pre)/18.2° (post); “mismatch” (PI-LL) 7° (pre)/ 6.6° (post), with no statistical difference among all parameters (p&gt;0.05). Conclusions: The MIS-TLIF technique had no influence on postoperative spinopelvic parameters of patients undergoing lumbar arthrodesis surgery. Level of evidence: III. Retrospective comparative study.
DOI: 10.6084/m9.figshare.7773110.v1
title: Temporomandibular joint disc displacement with reduction: a review of mechanisms and clinical presentation

description: Abstract Disc displacement with reduction (DDWR) is one of the most common intra-articular disorders of the temporomandibular joint (TMJ). Factors related to the etiology, progression and treatment of such condition is still a subject of discussion. This literature review aimed to address etiology, development, related factors, diagnosis, natural course, and treatment of DDWR. A non-systematic search was conducted within PubMed, Scopus, SciELO, Medline, LILACS and Science Direct using the Medical Subjective Headings (MeSH) terms “temporomandibular disorders”, “temporomandibular joint”, “disc displacement” and “disc displacement with reduction”. No time restriction was applied. Literature reviews, systematic reviews, meta-analysis and clinical trials were included. DDWR is usually asymptomatic and requires no treatment, since the TMJ structures adapt very well and painlessly to different disc positions. Yet, long-term studies have shown the favorable progression of this condition, with no pain and/or jaw locking occurring in most of the patients.