DOI: 10.25550/1-x5f0
title: Gene summary for BMP4

description: #### Genome Browser Links: [mm9](http://genome.ucsc.edu/cgi-bin/hgTracks?db=mm9&singleSearch=knownCanonical&position=BMP4) | [mm10](http://genome.ucsc.edu/cgi-bin/hgTracks?db=mm10&singleSearch=knownCanonical&position=BMP4) | [hg18](http://genome.ucsc.edu/cgi-bin/hgTracks?db=hg18&singleSearch=knownCanonical&position=BMP4) | [hg19](http://genome.ucsc.edu/cgi-bin/hgTracks?db=hg19&singleSearch=knownCanonical&position=BMP4) #### Reference Images: | E12.5 | E13.5 | E14.5 | E15.5 | |-------|-------|-------|-------| | ![Image](/hatrac/facebase/genesummaries/Bmp4_anterior_E12.5.jpg) | ![Image](/hatrac/facebase/genesummaries/Bmp4_anterior_E13.5.jpg) | ![Image](/hatrac/facebase/genesummaries/Bmp4_anterior_E14.5.jpg) | ![Image](/hatrac/facebase/genesummaries/Bmp4_anterior_E15.5.jpg) | #### Gene expression in the secondary palate: _Bmp4_ is expressed in both epithelium and mesenchyme at E12.5. Its expression is restricted to the mesenchyme from E13.5. _Bmp4_ is expressed only in the anterior and distal regions of the palatal shelves. | | E12.5 | E13.5 | E14.5 | E15.5 | |--------|-------|-------|-------|-------| | **Coronal** | [![ImageWithSize](/hatrac/facebase/genesummaries/Bmp4_coronal_E12.5_0.jpg){width=100}](/hatrac/facebase/genesummaries/Bmp4_coronal_E12.5_0.jpg) | [![ImageWithSize](/hatrac/facebase/genesummaries/Bmp4_coronal_E13.5_0.jpg){width=100}](/hatrac/facebase/genesummaries/Bmp4_coronal_E13.5_0.jpg) | [![ImageWithSize](/hatrac/facebase/genesummaries/Bmp4_coronal_E14.5_0.jpg){width=100}](/hatrac/facebase/genesummaries/Bmp4_coronal_E14.5_0.jpg) | ![Image](/hatrac/facebase/genesummaries/blank.gif) | | **Intraoral** | [![ImageWithSize](/hatrac/facebase/genesummaries/Bmp4_oral_E12.5_0.jpg){width=100}](/hatrac/facebase/genesummaries/Bmp4_oral_E12.5_0.jpg) | [![ImageWithSize](/hatrac/facebase/genesummaries/Bmp4_oral_E13.5_0.jpg){width=100}](/hatrac/facebase/genesummaries/Bmp4_oral_E13.5_0.jpg) | [![ImageWithSize](/hatrac/facebase/genesummaries/Bmp4_oral_E14.5_0.jpg){width=100}](/hatrac/facebase/genesummaries/Bmp4_oral_E14.5_0.jpg) | | N: Nasal Pr: Proximal Di: Distal O: Oral ![Image](/hatrac/facebase/genesummaries/A0AA87.gif) Distal mesenchyme (PrDi axis) ![Image](/hatrac/facebase/genesummaries/ECB177.gif) Anterior mesenchyme (AP axis) ![ImageWithSize](/hatrac/facebase/genesummaries/legend_blue_line.png){width=46} All epithelium #### Sources: - Zhang et al. (2002) [Rescue of cleft palate in Msx1-deficient mice by transgenic Bmp4 reveals a network of BMP and Shh signaling in the regulation of mammalian palatogenesis.](http://www.ncbi.nlm.nih.gov/pubmed/12163415) Development 129(17): 4135-46. - Unpublished data from [Chai Lab, University of Southern California.](http://face.usc.edu/) #### Related Datasets: - [All related FaceBase data for Bmp4](https://www.facebase.org/data/recordset/#1/isa:dataset/*::facets::N4IghgdgJiBcDaoDOB7ArgJwMYFM6JAEsIAjdafIpMEAGhCjABcwkcmB9Acxwhw8Ys2nQlA4AzANY4AniAC6AX1qh0TMmgoIqNeoNbtuvfjz4TpcpXpIAPDDnEL6WABYpCuJJXFhcJA7AAzACcwbAKikpAA) #### External Links: - [Bmp4 bone morphogenetic protein 4 [ Mus musculus (house mouse) ] ](http://www.ncbi.nlm.nih.gov/gene/12159) - [Bmp4 bone morphogenetic protein 4 [ Homo sapiens (human) ]](http://www.ncbi.nlm.nih.gov/gene/652) - [Bmp4 homeobox 1](http://www.genecards.org/cgi-bin/carddisp.pl?gene=BMP4&search=bmp4) - [Bmp4 Wikipedia](http://en.wikipedia.org/wiki/BMP4)