DOI: 10.5061/dryad.ft5sk66
title: Data from: Association of antibiotic exposure with the mortality in metastatic colorectal cancer patients treated with bevacizumab-containing chemotherapy: a hospital-based retrospective cohort study

description: Background: Preclinical studies showed that antibiotic exposure played a
 role in clinical outcomes in patients with chemotherapy via modulation of
 microbiota. However, it remains unknown whether antibiotic exposure during
 the bevacizumab therapy affects the clinical outcomes in metastatic
 colorectal cancer(mCRC) patients. This study aimed to examine the
 association between the antibiotic medication and the clinical outcomes in
 mCRC patients with bevacizumab therapy. Methods: This retrospective cohort
 analysis included 147 mCRC patients treated with bevacizumab. The hazard
 ratio of death was estimated using three Cox proportional hazards models
 with (1) never vs ever; (2) never vs 1-6 days and 7-40 days;(3) increase
 per day, and further tested using propensity score matching (PSM) and
 landmark analysis. A smooth curve technique was used to explore the shape
 of dose-response relationship. Results: Compared with the non-antibiotic
 group, antibiotic exposure was inversely associated with the mortality in
 the antibiotic group after adjustment for demographic and other potential
 confounders (a history of medication: HR, 0.650(95%CI: 0.360 to 1.173); an
 increase per day: HR, 0.967(CI: 0.924 to 1.011); 1-6 days: HR, 0.859(CI:
 0.441 to 1.674); 7-40 days: HR, 0.474(CI: 0.225 to 0.999); P for
 trend=0.040). A test for the interaction between sex was statistically
 significant (p=0.016). A similar result was found as measured by landmark
 and PSM analysis. Significant negative dose-response relationship was
 shown by smooth curve analysis in the male patients but not female after
 adjustment for confounders(p=0.028). No association was found between the
 antibiotic medication and adverse events of bevacizumab. Conclusion:
 Antibiotic exposure could be inversely associated with the mortality in
 mCRC patients treated with bevacizumab.
description: Association of antibiotic exposure with the mortality in
 mCRC Background: Preclinical studies showed that
 antibiotic exposure played a role in clinical outcomes in patients with
 chemotherapy via modulation of microbiota. However, it remains unknown
 whether antibiotic exposure during the bevacizumab therapy affects the
 clinical outcomes in metastatic colorectal cancer(mCRC) patients. This
 study aimed to examine the association between the antibiotic medication
 and the clinical outcomes in mCRC patients with bevacizumab therapy.
 Methods: This retrospective cohort analysis included 147 mCRC patients
 treated with bevacizumab. The hazard ratio of death was estimated using
 three Cox proportional hazards models with (1) never vs ever; (2) never vs
 1-6 days and 7-40 days;(3) increase per day, and further tested using
 propensity score matching (PSM) and landmark analysis. A smooth curve
 technique was used to explore the shape of dose-response relationship.
 Results: Compared with the non-antibiotic group, antibiotic exposure was
 inversely associated with the mortality in the antibiotic group after
 adjustment for demographic and other potential confounders (a history of
 medication: HR, 0.650(95%CI: 0.360 to 1.173); an increase per day: HR,
 0.967(CI: 0.924 to 1.011); 1-6 days: HR, 0.859(CI: 0.441 to 1.674); 7-40
 days: HR, 0.474(CI: 0.225 to 0.999); P for trend=0.040). A test for the
 interaction between sex was statistically significant (p=0.016). A similar
 result was found as measured by landmark and PSM analysis. Significant
 negative dose-response relationship was shown by smooth curve analysis in
 the male patients but not female after adjustment for
 confounders(p=0.028). No association was found between the antibiotic
 medication and adverse events of bevacizumab. Conclusion: Antibiotic
 exposure could be inversely associated with the mortality in mCRC patients
 treated with bevacizumab.
 antibiotic_bevacizumab.xls