cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.25402/bio.24160959
title: Solid-phase extraction of gallic acid andascorbic acid in fruits using polymerizeddeep eutectic solvent-modified substrate: supplementary materials

description: Aim: Novel substrates were synthesized by porous and nonporous polymerization of deep eutectic solventson magnetic silica nanoparticles and introduced for dispersive solid-phase extraction of two analytes.Materials & methods: The prepared substrates were characterized, and an extraction procedure wasimplemented to select the best substrates and eluent. The central composite design acted to optimizethe effects of parameters that influenced the extraction efficiencies. Results: For gallic and ascorbic acids,the limits of detection were obtained at 0.136 and 0.165 μM, respectively, with linear ranges of 0.6–125.2and 0.5–106.8 μM, respectively. Conclusion: The substrate produced good extractions even after beingused three-times and was successfully applied for the analysis of real samples.
DOI: 10.25402/bio.24160959.v1
title: Solid-phase extraction of gallic acid andascorbic acid in fruits using polymerizeddeep eutectic solvent-modified substrate: supplementary materials

description: Aim: Novel substrates were synthesized by porous and nonporous polymerization of deep eutectic solventson magnetic silica nanoparticles and introduced for dispersive solid-phase extraction of two analytes.Materials & methods: The prepared substrates were characterized, and an extraction procedure wasimplemented to select the best substrates and eluent. The central composite design acted to optimizethe effects of parameters that influenced the extraction efficiencies. Results: For gallic and ascorbic acids,the limits of detection were obtained at 0.136 and 0.165 μM, respectively, with linear ranges of 0.6–125.2and 0.5–106.8 μM, respectively. Conclusion: The substrate produced good extractions even after beingused three-times and was successfully applied for the analysis of real samples.
DOI: 10.25402/bio.24324127
title: Fabry disease biomarkers in patientsswitched from enzyme replacement therapyto migalastat oral chaperone therapy: supplementary table 1

description: Background: A biomarker profile was evaluated longitudinally in patients with Fabry disease switchedfrom enzyme replacement therapy (ERT) to migalastat. Methods: Sixteen Gb3 isoforms and eight lyso-Gb3 analogues were analyzed in plasma and urine by LC–MS/MS at baseline and at three different timepoints in naive participants and participants switching from either agalsidase α or β to migalastat. Results:Twenty-nine adult participants were recruited internationally (seven centers). The Mainz Severity ScoreIndex and mean biomarker levels remained stable (p ≥ 0.05) over a minimum of 12 months comparedwith baseline following the treatment switch. Conclusion: In this cohort of patientswith Fabry diseasewithamenable mutations, in the short term, a switch from ERT to migalastat did not have a marked effect onthe average biomarker profile.
DOI: 10.25402/bio.24324127.v1
title: Fabry disease biomarkers in patientsswitched from enzyme replacement therapyto migalastat oral chaperone therapy: supplementary table 1

description: Background: A biomarker profile was evaluated longitudinally in patients with Fabry disease switchedfrom enzyme replacement therapy (ERT) to migalastat. Methods: Sixteen Gb3 isoforms and eight lyso-Gb3 analogues were analyzed in plasma and urine by LC–MS/MS at baseline and at three different timepoints in naive participants and participants switching from either agalsidase α or β to migalastat. Results:Twenty-nine adult participants were recruited internationally (seven centers). The Mainz Severity ScoreIndex and mean biomarker levels remained stable (p ≥ 0.05) over a minimum of 12 months comparedwith baseline following the treatment switch. Conclusion: In this cohort of patientswith Fabry diseasewithamenable mutations, in the short term, a switch from ERT to migalastat did not have a marked effect onthe average biomarker profile.
DOI: 10.25549/examiner-c44-19569
title: Plane crash and fire...West El Monte, 1951

description: 14 images. Plane crash and fire...West El Monte, 5 September 1951. James B. Howell -- 67 years (father of dead boy); Eva Howell -- 39 years (his wife); Robert White, Junior -- 13 years (playmate of dead boy); Cocker Spaniel "Pal"; Raymond James Howell -- 16 years; Ersel Syfert -- 16 years (girl friend of dead boy).; Caption slip reads: "Photographer: McCarty. Date: 1951-09-05. Reporter: Rose. Assignment: West El Monte Plane crash and fire. 41, 42: Lt. to Rt.: James B. Howell, 67, father of dead boy, and his wife, Eva, 39, seated in car before leaving scene in dazed condition. 37, 38: Wreckage of plane into rear of house at 2317 North Loma Ave., West El Monte. 51, 52: In tears, Ersel Syfert, 16, dead boy's girl friend, consoles his cocker spaniel Pal. 53: Charred body (wrapped in rubber sheet) of Raymond James Howell, 16. 42: County firemen looking at body of unidentified pilot. 55: Unidentified pilot's body. 49 & 50: Robert White Jr., 13, playmate of dead boy, consoles the boy's cocker spaniel, Pal. 45 & 48: Copy of picture of dead boy, Raymond James Howell, 16".
DOI: 10.15468/dl.ndjsh4
title: Occurrence Download

description: A dataset containing 3735321 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Calypte anna (R.Lesson, 1829))",
 "Country is one of (United States of America)",
 "HasCoordinate is true",
 "HasGeospatialIssue is false"
 ]
}

 The dataset includes 3735321 records from 73 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0018168-240506114902167/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.25402/bio.24324148
title: Measurement of free fraction, totalconcentration and protein binding fortestosterone, triiodothyronine and thyroxine: supplementary data

description: Aims: Measuring the total and free concentrations of hormones is useful, but the technology to dothis simultaneously is lacking. Methods: A new method offers the ability to measure these parametersconcurrently for testosterone, thyroxine and triiodothyronine. Results: The free concentrations showedsignificant correlations with patients’ vital statistics. Overall, 67% of correlations for total concentrationshowed that the new and classical methods had equal accuracy, or that comprehensive ultrafiltration wasmore accurate. The protein binding term was found to correlate significantlywith the patients’ luteinizinghormone, prostate-specific antigen and height. Conclusion: Comprehensive ultrafiltration for measuringthe total concentration, free concentration and protein binding term uses less sample and is much fasterthan measuring these parameters with three separate methods.
DOI: 10.25402/bio.24324148.v1
title: Measurement of free fraction, totalconcentration and protein binding fortestosterone, triiodothyronine and thyroxine: supplementary data

description: Aims: Measuring the total and free concentrations of hormones is useful, but the technology to dothis simultaneously is lacking. Methods: A new method offers the ability to measure these parametersconcurrently for testosterone, thyroxine and triiodothyronine. Results: The free concentrations showedsignificant correlations with patients’ vital statistics. Overall, 67% of correlations for total concentrationshowed that the new and classical methods had equal accuracy, or that comprehensive ultrafiltration wasmore accurate. The protein binding term was found to correlate significantlywith the patients’ luteinizinghormone, prostate-specific antigen and height. Conclusion: Comprehensive ultrafiltration for measuringthe total concentration, free concentration and protein binding term uses less sample and is much fasterthan measuring these parameters with three separate methods.
DOI: 10.25549/examiner-c44-75817
title: Mocambo Party for Mr. and Mrs. C. Ray Gilliland, 1954

description: 20 images. Mocambo Party for Mr. and Mrs. C. Ray Gilliland, 2 June 1954. Warden Woolard; Jon Hall; Mr. and Mrs. C. Ray Gilliland; Linda Danson; Hyatt Von Dehn; Beverly Thompson; Stefania Pignatelli; Alfredo De La Vega; Dr. and Mrs. O. Dale Lloyd; John Maschio; Michael T. FLynn; Kay Williams Spreckles; Paul Brinkman; Jeanne Crain; Mr. and Mrs. Richard Fewel; Mrs. Trevis Morrow.; Caption slip reads: "Photographer: Forbes. Date: 1954-06-02. Assignment: Party. 3: L to R - Hyatt Von Dehn; Beverly Thompson; Stefania Pignatelli. 4: Alfredo De La Vega. 64: Linda Danson & Jon Hall at table. 67: Dr & Mrs. O. Dale Lloyd. 68: John Maschio & Constance Moore, Michael T. Flynn & Kay William Spreckles. 68: Paul Brinkman & Jeanne Crain dancing. 69: Mr. & Mrs. Richard Fewel. 70: Mrs. Trevis Morrow; Mrs. John Maschio (Donnie Moore); Mr. Trevis Morrow. 72: Violinist Harold Stern serenading Mr. & Mrs. Gilliland. 73/74/75: Mr & Mrs. Gilliland & Charlie Morrison presenting cake. 95/96: Same.".
DOI: 10.25402/bio.24324316
title: Development and validation ofreversed-phase-HPLC method forsimultaneous quantification of fulvestrantand disulfiram in liposomes: supplementary materials

description: This study aims to develop and validate an HPLC technique for the determination of fulvestrant anddisulfiram in liposomes. Encapsulation of both drugs into liposomes may improve their anticancerpotential. Validation was performed following the International Conference on Harmonization guidelinesfor specificity, linearity, limit of detection, limit of quantification, precision, accuracy and robustness.Method specificity displayed no interference and linearity over 25–200 and 12.5–100 μg/ ml forfulvestrant and disulfiram, respectively. Precision and accuracy exhibited a low relative standard deviation(&lt;1.70%) and appropriate recovery. The validated method could be designated as a proper methodfor the simultaneous determination of fulvestrant and disulfiram in liposomes. The liposomes displayed148.5 ± 5.1 nm size. The encapsulation efficiencies were 73.52 and 50.50% for fulvestrant and disulfiram,respectively.
DOI: 10.25402/bio.24324316.v1
title: Development and validation ofreversed-phase-HPLC method forsimultaneous quantification of fulvestrantand disulfiram in liposomes: supplementary materials

description: This study aims to develop and validate an HPLC technique for the determination of fulvestrant anddisulfiram in liposomes. Encapsulation of both drugs into liposomes may improve their anticancerpotential. Validation was performed following the International Conference on Harmonization guidelinesfor specificity, linearity, limit of detection, limit of quantification, precision, accuracy and robustness.Method specificity displayed no interference and linearity over 25–200 and 12.5–100 μg/ ml forfulvestrant and disulfiram, respectively. Precision and accuracy exhibited a low relative standard deviation(&lt;1.70%) and appropriate recovery. The validated method could be designated as a proper methodfor the simultaneous determination of fulvestrant and disulfiram in liposomes. The liposomes displayed148.5 ± 5.1 nm size. The encapsulation efficiencies were 73.52 and 50.50% for fulvestrant and disulfiram,respectively.
DOI: 10.25549/examiner-c44-74561
title: Examiner War Wounded Fund (Christmas check to San Fernando Hospital), 1956

description: 5 images. Examiner War Wounded Fund (Christmas check to San Fernando Hospital), 13 December 1956. Sam Diannitto; Arturo Ordonez; Lowell C. Like; Clarence Gardner; Benjamin Parades.; Caption slip reads: "Photographer: Forbes. Date: 1956-12-13. Reporter: Driscoll. Assignment: Xmas check to San Fernando Vets Hospital. 88-129-130: L to R, Sam Diannitto; Arturo Ordonez; Lowell C.Like (Mgr.); Clarence Gardner; Benjamin Parades. To run Xmas. 03/04: Benjamin Parades; Sam Diannitto (in rear); Arturo Ordonez; Lowell C. Like (Mgr.); Clarence Gardner. To run Xmas".; Supplementary material reads: "San Fernando Veterans Administration Hospital. Lowell C. Like, manager, points out to a group of patients where picnic tables and benches are to be installed under the trees to provide an outdoor recreation center".
DOI: 10.25402/bio.24358117
title: Decentralized clinical trial design usingblood microsampling technology for serumbioanalysis: supplementary materials

description: Background: Alternatives to phlebotomy in clinical trials increase options for patients and cliniciansby simplifying and increasing accessibility to clinical trials. The authors investigated the technical andlogistical considerations of one technology compared with phlebotomy. Methodology: Paired sampleswere collected from 16 donors via a second-generation serum gel microsampling device and conventionalphlebotomy. Microsamples were subject to alternative sample handling conditions and were evaluatedfor quality, clinical testing and proteome profiling. Results: Timely centrifugation of blood serummicrosamples largely preserved analyte stability. Conclusion: Centrifugation timing of serummicrosamplesimpacts the quality of specific clinical chemistry and protein biomarkers. Microsampling devices withremote centrifugation and refrigerated shipping can decrease patient burden, expand clinical trialpopulations and aid clinical decisions.
DOI: 10.25402/bio.24358117.v1
title: Decentralized clinical trial design usingblood microsampling technology for serumbioanalysis: supplementary materials

description: Background: Alternatives to phlebotomy in clinical trials increase options for patients and cliniciansby simplifying and increasing accessibility to clinical trials. The authors investigated the technical andlogistical considerations of one technology compared with phlebotomy. Methodology: Paired sampleswere collected from 16 donors via a second-generation serum gel microsampling device and conventionalphlebotomy. Microsamples were subject to alternative sample handling conditions and were evaluatedfor quality, clinical testing and proteome profiling. Results: Timely centrifugation of blood serummicrosamples largely preserved analyte stability. Conclusion: Centrifugation timing of serummicrosamplesimpacts the quality of specific clinical chemistry and protein biomarkers. Microsampling devices withremote centrifugation and refrigerated shipping can decrease patient burden, expand clinical trialpopulations and aid clinical decisions.
DOI: 10.25402/bio.24466159
title: An eco-friendly ultra-performance liquidchromatography–mass spectrometry methodfor quantification of rivaroxaban andticagrelor in rat plasma: grapefruitinteractions: supplmentary data

description: Aim: An eco-friendly ultra-performance liquid chromatography–tandem mass spectrometry methodwas developed to study the pharmacokinetics of rivaroxaban and ticagrelor in rat plasma, utilizingmoxifloxacin as an internal standard. The food–drug interaction between grapefruit juice and these drugswas also investigated. Methods: Liquid–liquid extraction was used. A nonporous stationary phase Agilent R ?Poroshell 120EC C18 column was used with methanol: 0.1% aqueous formic acid (95:5 v/v) as a mobilephase. The detection was performed in multiple reaction monitoring mode using positive electrosprayionization. The method’s validation was conducted in accordance with US FDA and European MedicinesAgency guidelines. Results & conclusion: Grapefruit juice should be ingested with caution in patientstreated with antithrombotic medications as it may increase their plasma concentration, inducing bleeding,and requires close clinical monitoring.
DOI: 10.25402/bio.24466159.v1
title: An eco-friendly ultra-performance liquidchromatography–mass spectrometry methodfor quantification of rivaroxaban andticagrelor in rat plasma: grapefruitinteractions: supplmentary data

description: Aim: An eco-friendly ultra-performance liquid chromatography–tandem mass spectrometry methodwas developed to study the pharmacokinetics of rivaroxaban and ticagrelor in rat plasma, utilizingmoxifloxacin as an internal standard. The food–drug interaction between grapefruit juice and these drugswas also investigated. Methods: Liquid–liquid extraction was used. A nonporous stationary phase Agilent R ?Poroshell 120EC C18 column was used with methanol: 0.1% aqueous formic acid (95:5 v/v) as a mobilephase. The detection was performed in multiple reaction monitoring mode using positive electrosprayionization. The method’s validation was conducted in accordance with US FDA and European MedicinesAgency guidelines. Results & conclusion: Grapefruit juice should be ingested with caution in patientstreated with antithrombotic medications as it may increase their plasma concentration, inducing bleeding,and requires close clinical monitoring.
DOI: 10.25549/examiner-c44-15094
title: Gang shooting (confer on Trombino shooting), 1951

description: 2 images. Gang shooting (confer on Trombino shooting), 7 August 1951. William H. Parker (Chief of Police); Eugene W. Biscailuz (Sheriff); Ernest Roll (District Attorney); Rex Thomson (Undersheriff).
DOI: 10.25402/bio.24612045
title: Bioanalysis of six antibiotics from volumetricmicrosamples: a new tool for precisiondosing in critically ill children: supplementary materials

description: Background: Volumetric absorptive microsamples (VAMS) can support pharmacokinetic /pharmacodynamic studies. We present the bioanalytical method development for the simultaneousquantification of ampicillin, cefepime, ceftriaxone, meropenem, piperacillin, tazobactam , andvancomycin from VAMS. Methods & results: Optimal extraction, chromatographic , andmass spectrometryconditions were identified. Maximum extraction recoveries included 100 μl of water for rehydration andmethanol for protein precipitation. Chromatographic separation used Phenomenex Kinetex™ Polar C18column with a mobile phase comprising water/acetonitrile with formic acid and was fully validated.Hematocrit effects were only observed for vancomycin. Samples were stable for 90 days at -80◦C exceptfor meropenem, which was stable for 60 days. Conclusion: Multiple antibiotics can be assayed from asingle VAMS sample to facilitate pharmacokinetic/pharmacodynamic studies.
DOI: 10.25402/bio.24612045.v1
title: Bioanalysis of six antibiotics from volumetricmicrosamples: a new tool for precisiondosing in critically ill children: supplementary materials

description: Background: Volumetric absorptive microsamples (VAMS) can support pharmacokinetic /pharmacodynamic studies. We present the bioanalytical method development for the simultaneousquantification of ampicillin, cefepime, ceftriaxone, meropenem, piperacillin, tazobactam , andvancomycin from VAMS. Methods & results: Optimal extraction, chromatographic , andmass spectrometryconditions were identified. Maximum extraction recoveries included 100 μl of water for rehydration andmethanol for protein precipitation. Chromatographic separation used Phenomenex Kinetex™ Polar C18column with a mobile phase comprising water/acetonitrile with formic acid and was fully validated.Hematocrit effects were only observed for vancomycin. Samples were stable for 90 days at -80◦C exceptfor meropenem, which was stable for 60 days. Conclusion: Multiple antibiotics can be assayed from asingle VAMS sample to facilitate pharmacokinetic/pharmacodynamic studies.
DOI: 10.25549/examiner-c44-75891
title: Finn twins leaving California Medical Facility at Terminal Island, 1954

description: 23 images. Finn twins leaving California Medical Facility at Terminal Island, 14 July 1954. George Finn; Charles Finn; Patricia Lynn; Jack Schuler; Attorney Bernard Cohen.
DOI: 10.25402/bio.24679365
title: Signal-to-noise ratio to assess magnitude,kinetics and impact on pharmacokinetics ofthe immune response to an adalimumabbiosimilar: supplementary material

description: Background: The antidrug antibody (ADA) signal-to-noise (S/N) ratio was explored as a novelimmunogenicity measure to evaluate the immune response of healthy subjects to a single dose of GP2017,an adalimumab biosimilar. Methodology/results: Bioanalytical methods used for the analysis of ADA S/Nratios and ADA titers were validated for sensitivity, precision and drug interference. ADA S/N ratiosstrongly correlated with ADA titers. Correlations between ADA area under the curve and ADAmax andpharmacokinetics (PK) were stronger for ADA S/N ratio than for ADA titers. Conclusion: ADA S/N ratioallowed for a more sensitive evaluation of themagnitude and kinetics of the immune response, was bettercorrelated with adalimumab PK and was superior to ADA titers in assessing the impact of the immuneresponse on PK.
DOI: 10.25402/bio.24679365.v1
title: Signal-to-noise ratio to assess magnitude,kinetics and impact on pharmacokinetics ofthe immune response to an adalimumabbiosimilar: supplementary material

description: Background: The antidrug antibody (ADA) signal-to-noise (S/N) ratio was explored as a novelimmunogenicity measure to evaluate the immune response of healthy subjects to a single dose of GP2017,an adalimumab biosimilar. Methodology/results: Bioanalytical methods used for the analysis of ADA S/Nratios and ADA titers were validated for sensitivity, precision and drug interference. ADA S/N ratiosstrongly correlated with ADA titers. Correlations between ADA area under the curve and ADAmax andpharmacokinetics (PK) were stronger for ADA S/N ratio than for ADA titers. Conclusion: ADA S/N ratioallowed for a more sensitive evaluation of themagnitude and kinetics of the immune response, was bettercorrelated with adalimumab PK and was superior to ADA titers in assessing the impact of the immuneresponse on PK.
DOI: 10.25402/bio.24679380
title: Quality control of psychoactive substances inhuman breastmilk samples from a humanmilk bank by disposable pipetteextraction–gas chromatography–massspectrometry: supplementary material

description: The lack of data regarding infant exposure to drugs of abuse consumed by lactating mothers has becomea major health concern. Investigating psychoactive substances and their metabolites in breastmilk is ananalytical approach to estimate the rate at which drugs of abuse are excreted and how much infantsare exposed to them. In this study, we have developed and validated a GC–MS method using disposablepipette tips for simultaneously extracting ten analytes from breastmilk samples obtained from a milk bankin the city of Ribeir ˜ao Preto, Brazil. All the 67 analyzed samples tested negative for all the analytes. Thisis the first study that has applied disposable pipette extraction to analyze drugs of abuse in breastmilksamples.
DOI: 10.25402/bio.24679380.v1
title: Quality control of psychoactive substances inhuman breastmilk samples from a humanmilk bank by disposable pipetteextraction–gas chromatography–massspectrometry: supplementary material

description: The lack of data regarding infant exposure to drugs of abuse consumed by lactating mothers has becomea major health concern. Investigating psychoactive substances and their metabolites in breastmilk is ananalytical approach to estimate the rate at which drugs of abuse are excreted and how much infantsare exposed to them. In this study, we have developed and validated a GC–MS method using disposablepipette tips for simultaneously extracting ten analytes from breastmilk samples obtained from a milk bankin the city of Ribeir ˜ao Preto, Brazil. All the 67 analyzed samples tested negative for all the analytes. Thisis the first study that has applied disposable pipette extraction to analyze drugs of abuse in breastmilksamples.
DOI: 10.25549/examiner-c44-75552
title: Los Angeles city budget, 1954

description: 4 images. Los Angeles city budget, 9 June 1954. E. Talbot Callister; William A. Pixley.; Caption slip reads: "Photographer: Mitchell. Date: 1954-06-09. Reporter: Reay. Assignment: Budget. 13/14: E. Talbot Callister. 61/62: William A. Pixley".