cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.13369753.v1
title: Validation and initial results of surveys exploring perspectives on risks and solutions for diagnostic and medication errors in primary care in Sweden

description: To (1) validate and (2) display initial results of surveys to health care professionals and patients on the importance and mitigation of specified risks for diagnostic and medication errors. For validation, psychometric properties were analysed by assessment of construct validity and internal consistency by factor analysis. Non-parametric analyses were used concerning areas of risk, and top ranking of solutions were reported descriptively. Primary health care in Sweden. Health care professionals (HCPs); including physicians, nurses and practice managers, as well as patients who had experienced diagnostic or medication errors. Psychometric properties of the surveys. Median ratings for risks and top rankings of solutions for professionals and patients. There were 939 respondents to the HCP survey. Construct validity resulted in a model with four dimensions: Patient-provider level; Support systems for every day clinical work; Shared information and cooperation between different caregivers; Risks in the environment. Internal consistency was acceptable with Cronbach’s α values above 0.7. Confirmatory factor analysis generally showed an acceptable fit. Initial results from the professionals showed the importance of continuity of care, a nationwide on-line medical platform and cooperation in transfer of care. The patient survey could not be validated because of low response rate. The HCP survey showed some contradicting results regarding model fit and may be tentatively acceptable but validity needs further study. HCP survey answers indicated that relational continuity of care and a nationwide on-line medical platform are highly valued.Current awarenessHealth care professionals and patients are rather untapped sources of knowledge regarding patient safety in primary health careMain statementsValidation is performed on a new survey capturing rating of risks and solutions.The validation of the health care professional survey is tentatively acceptable.Survey answers indicate that health care professionals’ and patients’ perspectives are complementary. Health care professionals and patients are rather untapped sources of knowledge regarding patient safety in primary health care Validation is performed on a new survey capturing rating of risks and solutions. The validation of the health care professional survey is tentatively acceptable. Survey answers indicate that health care professionals’ and patients’ perspectives are complementary.
DOI: 10.6084/m9.figshare.13060284
title: Pediatric Teleheath: Opportunities Created by the COVID-19 and Suggestions to Sustain Its Use to Support Families of Children with Disabilities

description: Telehealth is being rapidly adopted by physical and occupational therapists in pediatrics as a strategy to maintain services during the COVID-19 crisis. This perspective presents a mix of theoretical and practice perspectives to support the implementation of telehealth. Although research evidence is just emerging, there is sufficient indication to believe telehealth is effective. However, which telehealth strategies are best for which children and families, and which intervention goals, are not yet clear. We discuss how different telehealth strategies (e.g. videoconferencing, emails, phone calls, online programs) are being used to address specific intervention goals. Comments from therapists using telehealth and examples of practices in different context and with different populations are provided. We discuss how newly adopted telehealth practices could be included in future hybrid service delivery models and programs, as well as factors influencing the decision to offer face-to-face or online interventions. Although telehealth has been implemented quickly as a response to a health care crisis, and is not a one-size-fits-all intervention, we believe it offers great opportunities to increase the accessibility, cost-effectiveness and family-centredness of our services, to best support families of children with disabilities.
DOI: 10.6084/m9.figshare.13060284.v1
title: Pediatric Teleheath: Opportunities Created by the COVID-19 and Suggestions to Sustain Its Use to Support Families of Children with Disabilities

description: Telehealth is being rapidly adopted by physical and occupational therapists in pediatrics as a strategy to maintain services during the COVID-19 crisis. This perspective presents a mix of theoretical and practice perspectives to support the implementation of telehealth. Although research evidence is just emerging, there is sufficient indication to believe telehealth is effective. However, which telehealth strategies are best for which children and families, and which intervention goals, are not yet clear. We discuss how different telehealth strategies (e.g. videoconferencing, emails, phone calls, online programs) are being used to address specific intervention goals. Comments from therapists using telehealth and examples of practices in different context and with different populations are provided. We discuss how newly adopted telehealth practices could be included in future hybrid service delivery models and programs, as well as factors influencing the decision to offer face-to-face or online interventions. Although telehealth has been implemented quickly as a response to a health care crisis, and is not a one-size-fits-all intervention, we believe it offers great opportunities to increase the accessibility, cost-effectiveness and family-centredness of our services, to best support families of children with disabilities.
DOI: 10.6084/m9.figshare.14531463.v2
title: Peripheral blood interleukin 6, interleukin 10, and T lymphocyte levels are associated with checkpoint inhibitor induced pneumonitis: a case report

description: Peripheral blood interleukin 6, interleukin 10, and T lymphocyte levels are associated with checkpoint inhibitor induced pneumonitis: a case report
DOI: 10.6084/m9.figshare.14531463
title: Peripheral blood interleukin 6, interleukin 10, and T lymphocyte levels are associated with checkpoint inhibitor induced pneumonitis: a case report

description: Peripheral blood interleukin 6, interleukin 10, and T lymphocyte levels are associated with checkpoint inhibitor induced pneumonitis: a case report
DOI: 10.6084/m9.figshare.14559750
title: Unconditional T-fields

description: Important note: For unconditional fields, Field 33 is removed from all 3 types (high-T connected, low-T connected and Gaussian fields) because the extraction well dries out.<br>H means high-T connectedL means low-T connectedN means Gaussian fields
DOI: 10.6084/m9.figshare.14559750.v1
title: Unconditional T-fields

description: Important note: For unconditional fields, Field 33 is removed from all 3 types (high-T connected, low-T connected and Gaussian fields) because the extraction well dries out.<br>H means high-T connectedL means low-T connectedN means Gaussian fields
DOI: 10.6084/m9.figshare.14559717
title: Conditional T-fields

description: Conditional meaning the transmissivity at the location of pumping is taken constant.T:transmissivityN: Gaussian fields: ln(T) at the extraction well: 0.2H: High-T connected fields: ln(T) at the extraction well: +1L: Low-T connected fields: ln(T) at the extraction well: -1
DOI: 10.6084/m9.figshare.14560674.v1
title: Modflow Outputs as drawdowns - Unconditional Fields

description: 500_501 : observation well is located at r/I=0.1500_505: observation well is located at r/I=0.5500_520: observation well is located at r/I=2<br>Normally, Modflow gives the head levels but here, these are converted to drawdowns: drawdown=20-new head since the initial water head is taken as 20 everywhere
DOI: 10.6084/m9.figshare.14560674
title: Modflow Outputs as drawdowns - Unconditional Fields

description: 500_501 : observation well is located at r/I=0.1500_505: observation well is located at r/I=0.5500_520: observation well is located at r/I=2<br>Normally, Modflow gives the head levels but here, these are converted to drawdowns: drawdown=20-new head since the initial water head is taken as 20 everywhere
DOI: 10.6084/m9.figshare.14560686
title: Modflow Outputs as drawdowns - Conditional Fields

description: 500_501: observation well is located at r/I=0.1500_505: observation well is located at r/I=0.5500_520: observation well is located at r/I=2<br>Normally, Modflow gives the head levels. But here, the values are converted to drawdowns: drawdown=20-new head since the initial water head is taken as 20 everywhere<br>
DOI: 10.6084/m9.figshare.12299063
title: Herculean mistake: mephentermine associated cardiomyopathy

description: <b>Case presentation</b>: A 32-year-old professional bodybuilder presented with acute decompensated heart failure. He gave a history of anabolic androgenic steroids (AAS) use for &gt;2 years and mephentermine use for the preceding 3 months. <b>Management</b>: Transthoracic echocardiography showed severe left ventricular (LV) dysfunction with a large pedunculated, mobile thrombus attached to the ventricular apex. The patient had an embolic stroke during the hospital stay, with complete neurological recovery. Following the cessation of mephentermine use, there was a steady improvement in LV function over a follow-up of 2 months. However, at 3 months, his ventricular function showed deterioration, which coincided with mephentermine reuse. <b>Take home message</b>: Though AAS abuse by athletes leading to such a presentation has been documented, to the best of our knowledge, a similar role of mephentermine has not been reported.
DOI: 10.6084/m9.figshare.12299063.v1
title: Herculean mistake: mephentermine associated cardiomyopathy

description: <b>Case presentation</b>: A 32-year-old professional bodybuilder presented with acute decompensated heart failure. He gave a history of anabolic androgenic steroids (AAS) use for &gt;2 years and mephentermine use for the preceding 3 months. <b>Management</b>: Transthoracic echocardiography showed severe left ventricular (LV) dysfunction with a large pedunculated, mobile thrombus attached to the ventricular apex. The patient had an embolic stroke during the hospital stay, with complete neurological recovery. Following the cessation of mephentermine use, there was a steady improvement in LV function over a follow-up of 2 months. However, at 3 months, his ventricular function showed deterioration, which coincided with mephentermine reuse. <b>Take home message</b>: Though AAS abuse by athletes leading to such a presentation has been documented, to the best of our knowledge, a similar role of mephentermine has not been reported.
DOI: 10.6084/m9.figshare.12851123
title: Muscular strength and cardiovascular risk factors in adults: a systematic review

description: The purpose of this study was to identify and summarize the relationships between MS and individual components of metabolic syndrome (MetS) [high waist circumference (WC), high blood pressure (BP), high systolic blood pressure (SBP), high diastolic blood pressure (DBP), high triglycerides (TG), fasting blood glucose (GL) and low HDL cholesterol levels (HDL-C)] in adults. A systematic review was performed on six electronic databases (Lilacs, Pubmed, Scielo, Scopus, Sportdiscus, and Web of Knowledge), with complimentary searches in reference lists. The databases were investigated without restrictions regarding the period of publication. Of the 6,833 articles initially identified, 17 were included, with data on 43,343 adults. Higher MS values were associated with lower WC values. Different results in relation to the association between MS and BP, MS and SBP, and MS and DBP were verified. In addition, inconclusive results were verified in the relationship between MS and TG, MS and HDL-C, and MS and GL. Higher MS values were related with lower WC in adults. More evidence from longitudinal studies with high methodological rigor is needed to elucidate the relationship between MS and CVD among adults.
DOI: 10.6084/m9.figshare.12851123.v1
title: Muscular strength and cardiovascular risk factors in adults: a systematic review

description: The purpose of this study was to identify and summarize the relationships between MS and individual components of metabolic syndrome (MetS) [high waist circumference (WC), high blood pressure (BP), high systolic blood pressure (SBP), high diastolic blood pressure (DBP), high triglycerides (TG), fasting blood glucose (GL) and low HDL cholesterol levels (HDL-C)] in adults. A systematic review was performed on six electronic databases (Lilacs, Pubmed, Scielo, Scopus, Sportdiscus, and Web of Knowledge), with complimentary searches in reference lists. The databases were investigated without restrictions regarding the period of publication. Of the 6,833 articles initially identified, 17 were included, with data on 43,343 adults. Higher MS values were associated with lower WC values. Different results in relation to the association between MS and BP, MS and SBP, and MS and DBP were verified. In addition, inconclusive results were verified in the relationship between MS and TG, MS and HDL-C, and MS and GL. Higher MS values were related with lower WC in adults. More evidence from longitudinal studies with high methodological rigor is needed to elucidate the relationship between MS and CVD among adults.
DOI: 10.6084/m9.figshare.9204425.v1
title: Antiplatelet activity of deferiprone through cyclooxygenase-1 inhibition

description: Thalassemia patients are susceptible to both iron overload and thromboembolism. Deferiprone is an iron chelator that shows an antiplatelet activity and thus may alleviate platelet hyperactivation in thalassemia. Therefore, this study aimed to characterize the inhibitory effects and mechanisms of deferiprone on normal human platelets. The results illustrated that deferiprone inhibited platelet aggregation at the iron chelating concentrations (0.08–0.25 mmol/l). Deferiprone inhibited human platelet aggregation stimulated by arachidonic acid and ADP more potently than epinephrine and collagen, with the IC<sub>50</sub> of 0.24 mmol/l and 0.25 mmol/l <i>vs</i>. 3.36 mmol/l and 3.73 mmol/l, respectively. Interestingly, deferiprone significantly inhibited COX-1 activity, with the IC<sub>50</sub> of 0.33 mmol/l, and slightly increased cAMP level at the high concentration of 4 mmol/l. Moreover, the results from molecular docking showed that deferiprone interacted closely with key residues in the peroxidase active site of COX-1. These results suggested that deferiprone possessed antiplatelet activity mainly through the inhibition of COX-1 activity.
DOI: 10.6084/m9.figshare.9204425
title: Antiplatelet activity of deferiprone through cyclooxygenase-1 inhibition

description: Thalassemia patients are susceptible to both iron overload and thromboembolism. Deferiprone is an iron chelator that shows an antiplatelet activity and thus may alleviate platelet hyperactivation in thalassemia. Therefore, this study aimed to characterize the inhibitory effects and mechanisms of deferiprone on normal human platelets. The results illustrated that deferiprone inhibited platelet aggregation at the iron chelating concentrations (0.08–0.25 mmol/l). Deferiprone inhibited human platelet aggregation stimulated by arachidonic acid and ADP more potently than epinephrine and collagen, with the IC<sub>50</sub> of 0.24 mmol/l and 0.25 mmol/l <i>vs</i>. 3.36 mmol/l and 3.73 mmol/l, respectively. Interestingly, deferiprone significantly inhibited COX-1 activity, with the IC<sub>50</sub> of 0.33 mmol/l, and slightly increased cAMP level at the high concentration of 4 mmol/l. Moreover, the results from molecular docking showed that deferiprone interacted closely with key residues in the peroxidase active site of COX-1. These results suggested that deferiprone possessed antiplatelet activity mainly through the inhibition of COX-1 activity.
DOI: 10.6084/m9.figshare.9804656
title: Stimulation of mTORC2 by integrin αIIbβ3 is required for PI3Kβ-dependent activation of Akt but is dispensable for platelet spreading on fibrinogen

description: Phosphatidylinositol 3 kinase (PI3K) is a major player in platelet activation and regulates thrombus formation and stabilization. The β isoform of PI3K is implicated in integrin αIIbβ3 outside-in signaling, is required for the phosphorylation of Akt, and controls efficient platelet spreading upon adhesion to fibrinogen. In this study we found that during integrin αIIbβ3 outside-in signaling PI3Kβ-dependent phosphorylation of Akt on Serine473 is mediated by the mammalian target of rapamycin complex 2 (mTORC2). The activity of mTORC2 is stimulated upon platelet adhesion to fibrinogen, as documented by increased autophosphorylation. However, mTORC2 activation downstream of integrin αIIbβ3 is PI3Kβ-independent. Inhibition of mTORC2, but not mTORC1, also prevents Akt phosphorylation of Threonine308 and affects Akt activity, resulting in the inhibition of GSK3α/β phosphorylation. Nevertheless, mTORC2 or Akt inhibition does not alter PI3Kβ-dependent platelet spreading on fibrinogen. The activation of the small GTPase Rap1b downstream of integrin αIIbβ3 is regulated by PI3Kβ but is not affected upon inhibition of either mTORC2 or Akt. Altogether, these results demonstrate for the first time the activation of mTORC2 and its involvement in Akt phosphorylation and stimulation during integrin αIIbβ3 outside-in signaling. Moreover, the results demonstrate that the mTORC2/Akt pathway is dispensable for PI3Kβ-regulated platelet spreading on fibrinogen.
DOI: 10.6084/m9.figshare.9804656.v1
title: Stimulation of mTORC2 by integrin αIIbβ3 is required for PI3Kβ-dependent activation of Akt but is dispensable for platelet spreading on fibrinogen

description: Phosphatidylinositol 3 kinase (PI3K) is a major player in platelet activation and regulates thrombus formation and stabilization. The β isoform of PI3K is implicated in integrin αIIbβ3 outside-in signaling, is required for the phosphorylation of Akt, and controls efficient platelet spreading upon adhesion to fibrinogen. In this study we found that during integrin αIIbβ3 outside-in signaling PI3Kβ-dependent phosphorylation of Akt on Serine473 is mediated by the mammalian target of rapamycin complex 2 (mTORC2). The activity of mTORC2 is stimulated upon platelet adhesion to fibrinogen, as documented by increased autophosphorylation. However, mTORC2 activation downstream of integrin αIIbβ3 is PI3Kβ-independent. Inhibition of mTORC2, but not mTORC1, also prevents Akt phosphorylation of Threonine308 and affects Akt activity, resulting in the inhibition of GSK3α/β phosphorylation. Nevertheless, mTORC2 or Akt inhibition does not alter PI3Kβ-dependent platelet spreading on fibrinogen. The activation of the small GTPase Rap1b downstream of integrin αIIbβ3 is regulated by PI3Kβ but is not affected upon inhibition of either mTORC2 or Akt. Altogether, these results demonstrate for the first time the activation of mTORC2 and its involvement in Akt phosphorylation and stimulation during integrin αIIbβ3 outside-in signaling. Moreover, the results demonstrate that the mTORC2/Akt pathway is dispensable for PI3Kβ-regulated platelet spreading on fibrinogen.
DOI: 10.5281/zenodo.4733761
title: andrea-ballatore/litter-dynamics: Supplementary material

description: Supplementary material for A. Ballatore, T. J. Verhagen, Z. Li, S. Cucurachi, "This city is not a bin: Crowdmapping the distribution of urban litter", Journal of Industrial Ecology, 2021
DOI: 10.5880/sfb806.65
title: Potential raw material sources for the production of lithic artefacts in western Central Europe – GIS-data for the Rhineland, Westphalia, and the Benelux countries

description: The GIS dataset contains 19 recent geological formation/ deposit shape files that keep lithic raw material used during the Palaeolithic, Mesolithic and Neolithic periods. The geological data was gained from published digital maps (Carte géologique du Grand-Duché de Luxembourg 1998, GÜK200 2007, NRW: IS GK 100 DS 2009, Surface lithology (INSPIRE) 2016) whereas the data for 3 datasets on single outcrops, extraction sites and mining sites was collected during the D4 project phase (CRC 806). Further, out of the D4 project database 3 additive datasets where created describing the location of a singular Meuse gravel flint deposit close to Hambach, former tertiary quartzite (tertiary silcrete) and chalcedony sources (Floss 1994). The spatial analysis of lithic raw material sources is a valuable tool to identify Stone Age communication areas and regions of economic activities through different stages. Based on the combination of geological data and the D4 sites database potential Palaeolithic and Mesolithic foraging areas have been calculated for the D4 study area located in western Germany (NRW, Hessen, Rhineland-Palatinate, Saarland), and neighbouring Luxembourg, Belgium (Wallonia), and the southern Netherlands (Limburg) (Gehlen et al. submitted; Schmidt et al., in prep.). References Birgit Gehlen, Mirijam Zickel, Jehanne Affolter, Kai Vogl, Christian Willmes, submitted, Potential raw material sources for the production of lithic artefacts in western Central Europe – GIS-data for the Rhineland, Westphalia, and the Benelux countries. Submitted for Quaternary International, Special Issue “Rockview. Raw material sourcing of the prehistoric flint artefacts”. Isabell Schmidt, Jehanne Affolter, Alvaro Arrizabalaga, Nico Arts, Nuno Bicho, Philippe Crombé, Birgit Gehlen, Sonja B. Grimm, Andreas Maier, Nicholas Naudinot, Marcel Niekus, Mathieu Langlais, Marco Peresani, Florian Sauer, Werner Schön, Iwona Sobkowiak-Tabaka, Hans Vandendriesche, Mara-Julia Weber, Katja Winkler, Annabell Zander, Andreas Zimmermann, Final Palaeolithic demographic estimates. In prep.
DOI: 10.5281/zenodo.4743884
title: IDSL.IPA generated peaklists for the MTBLS1040 study

description: LC/MS data files from the MTBLS1040 study were re-processed using a new peak analyzer software IDSL.IPA to generate comprehensive metabolomics datasets. This dataset contains the IPA generated individual peak list for each LC/MS file in this study.
DOI: 10.5281/zenodo.4743883
title: IDSL.IPA generated peaklists for the MTBLS1040 study

description: LC/MS data files from the MTBLS1040 study were re-processed using a new peak analyzer software IDSL.IPA to generate comprehensive metabolomics datasets. This dataset contains the IPA generated individual peak list for each LC/MS file in this study.
DOI: 10.5281/zenodo.4743894
title: IDSL.IPA generated peaklists for the IROA compound library standards (THSTI data) - Orbitrap Fusion

description: LC/MS data files (Orbitrap Fusion) for IROA compounds were processed using a new peak analyzer software IDSL.IPA. This dataset contains the IDSL.IPA generated individual peak list for each LC/MS file in this study. Data were collected in the RP-ESI (+) mode.
DOI: 10.5281/zenodo.4743893
title: IDSL.IPA generated peaklists for the IROA compound library standards (THSTI data) - Orbitrap Fusion

description: LC/MS data files (Orbitrap Fusion) for IROA compounds were processed using a new peak analyzer software IDSL.IPA. This dataset contains the IDSL.IPA generated individual peak list for each LC/MS file in this study. Data were collected in the RP-ESI (+) mode.
DOI: 10.5281/zenodo.4743898
title: Reverse Phase ESI POS Orbitrap Fusion data for IROA library standards by THSTI

description: IROA library standards were analyzed using a reverse-phase ESI POS Orbitrap Fusion analytical method. The DDA data are converted to mzML format using the MSConvert software.
DOI: 10.5281/zenodo.4743897
title: Reverse Phase ESI POS Orbitrap Fusion data for IROA library standards by THSTI

description: IROA library standards were analyzed using a reverse-phase ESI POS Orbitrap Fusion analytical method. The DDA data are converted to mzML format using the MSConvert software.
DOI: 10.6084/m9.figshare.14560818
title: Sandfoss et al. 2021 J Zoology

description: Dataset of raw values for stable isotopes and home ranges of the publication Sandfoss et al. 2021 in J Zoology.<br>