cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.15468/dl.wgwrcr
title: Occurrence Download

description: A dataset containing 566 species occurrences available in GBIF matching the query:
{
 "and" : [
 {
 "or" : [
 "Geometry POLYGON((9.46143 39.64307,18.07471 38.81689,14.15479 43.96729,11.55322 45.23291,9.18018 44.28369,8.354 43.86182,7.77393 42.59619,8.07275 41.03174,9.46143 39.64307))",
 "Geometry POLYGON((15.104 38.27197,18.90088 38.729,18.76025 41.29541,15.38525 44.26611,13.52197 46.34033,6.82471 45.68994,5.89307 44.70557,8.47705 38.90478,15.104 38.27197))"
 ]
 },
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 "TaxonKey is Perca fluviatilis Linnaeus, 1758"
 ]
}

 The dataset includes 566 records from 20 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0107230-200613084148143/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.taknz6
title: Occurrence Download

description: A dataset containing 210 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is Russian Federation",
 "Geometry POLYGON((31.55325 39.64381,59.84995 39.64381,59.84995 50.95751,31.55325 50.95751,31.55325 39.64381))",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 "TaxonKey is Phrynocephalus mystaceus (Pallas, 1776)"
 ]
}

 The dataset includes 210 records from 8 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0060100-231002084531237/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.ysg0c0
title: Occurrence Download

description: A dataset containing 1664951 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is Mexico",
 "HasCoordinate is false"
 ]
}

 The dataset includes 1664951 records from 812 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0000905-150831095807960/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.13130/rd_unimi/zbysir/3j6ris
title: Agosto_1900_Pagina_112.jpg

description: Bulletin of 1900/08/28
DOI: 10.13130/rd_unimi/zvkzj5/hhqxbw
title: Agosto_1918_Pagina_076.jpg

description: Bulletin of 1918/08/13
DOI: 10.13130/rd_unimi/cea2oy/ys5lcn
title: Aprile_1888_Pagina_076.jpg

description: Bulletin of 1888/04/19
DOI: 10.13130/rd_unimi/i5awbn/ioshcl
title: Agosto_1920_Pagina_072.jpg

description: Bulletin of 1920/08/12
DOI: 10.13130/rd_unimi/tdflym/pmtv2o
title: Aprile_1899_Pagina_048.jpg

description: Bulletin of 1899/04/12
DOI: 10.13130/rd_unimi/cmir61/qtg6kq
title: Aprile_1897_Pagina_067.jpg

description: Bulletin of 1897/04/17
DOI: 10.13130/rd_unimi/zvkzj5/fjiiqx
title: Agosto_1918_Pagina_077.jpg

description: Bulletin of 1918/08/13
DOI: 10.13130/rd_unimi/cgo8lw/eek16j
title: Agosto_1914_Pagina_086.jpg

description: Bulletin of 1914/08/15
DOI: 10.13130/rd_unimi/zbysir/yusbtu
title: Agosto_1900_Pagina_113.jpg

description: Bulletin of 1900/08/29
DOI: 10.13130/rd_unimi/cea2oy/6odum4
title: Aprile_1888_Pagina_077.jpg

description: Bulletin of 1888/04/20
DOI: 10.13130/rd_unimi/cmir61/ip26eh
title: Aprile_1897_Pagina_068.jpg

description: Bulletin of 1897/04/17
DOI: 10.13130/rd_unimi/i5awbn/tapkjo
title: Agosto_1920_Pagina_073.jpg

description: Bulletin of 1920/08/13
DOI: 10.13130/rd_unimi/tdflym/wyvzd0
title: Aprile_1899_Pagina_049.jpg

description: Bulletin of 1899/04/13
DOI: 10.13130/rd_unimi/i5awbn/hgbo49
title: Agosto_1920_Pagina_074.jpg

description: Bulletin of 1920/08/13
DOI: 10.13130/rd_unimi/zbysir/zntr44
title: Agosto_1900_Pagina_114.jpg

description: Bulletin of 1900/08/29
DOI: 10.13130/rd_unimi/zvkzj5/p4gc7j
title: Agosto_1918_Pagina_078.jpg

description: Bulletin of 1918/08/13
DOI: 10.13130/rd_unimi/cea2oy/dqi3fc
title: Aprile_1888_Pagina_078.jpg

description: Bulletin of 1888/04/20
DOI: 10.13130/rd_unimi/cgo8lw/k2lu2b
title: Agosto_1914_Pagina_087.jpg

description: Bulletin of 1914/08/15
DOI: 10.13130/rd_unimi/tdflym/xifxhm
title: Aprile_1899_Pagina_050.jpg

description: Bulletin of 1899/04/13
DOI: 10.13130/rd_unimi/cmir61/aklos5
title: Aprile_1897_Pagina_069.jpg

description: Bulletin of 1897/04/18
DOI: 10.6084/m9.figshare.30909317
title: Supplementary Material for: Biomarkers of glycolysis and the tricarboxylic acid (TCA) cycle in youth with and without obesity

description: Given the rising prevalence of childhood obesity, it is critical to understand the metabolic consequences of excess adiposity in youth. In particular, investigating alterations in glycolysis and the tricarboxylic acid (TCA) cycle in youth with obesity is essential for elucidating the underlying mechanisms contributing to metabolic dysregulation in this population. Forty-eight adolescents and young adults aged 15-24 years had plasma obtained after a 12-hour fasting to measure levels of glucose, insulin, and TCA cycle intermediates: pyruvate, lactate, fumarate, malate, α-ketoglutarate, cis/trans aconitate, and isocitrate. Additionally, participants underwent an assessment of liver proton-density fat fraction (PDFF) and a 3-hour oral glucose tolerance test (OGTT). Nineteen youth without obesity (BMI 21.5 ± 0.5 Kg/m2) and twenty-nine youth with obesity (BMI 37.3 ± 1.7 Kg/m2) were enrolled in the study. Youth with obesity showed higher plasma concentrations of lactate (P=0.009) and pyruvate (P=0.096) and lower plasma concentrations of fumarate (P=0.022), malate (P=0.009), cis/trans aconitate (P=0.03), and citrate/isocitrate (P=0.012). PDFF was also directly correlated with lactate (r=0.46, P=0.027). Adipose tissue insulin resistance was not associated with biomarkers of glycolysis. The metabolomic analysis revealed distinct characteristics between adolescents with and without obesity, thus demonstrating lower rates of aerobic glucose utilization in youth with obesity, which may contribute to the development of insulin resistance, type 2 diabetes, and cardiovascular disease.
DOI: 10.6084/m9.figshare.30909317.v1
title: Supplementary Material for: Biomarkers of glycolysis and the tricarboxylic acid (TCA) cycle in youth with and without obesity

description: Given the rising prevalence of childhood obesity, it is critical to understand the metabolic consequences of excess adiposity in youth. In particular, investigating alterations in glycolysis and the tricarboxylic acid (TCA) cycle in youth with obesity is essential for elucidating the underlying mechanisms contributing to metabolic dysregulation in this population. Forty-eight adolescents and young adults aged 15-24 years had plasma obtained after a 12-hour fasting to measure levels of glucose, insulin, and TCA cycle intermediates: pyruvate, lactate, fumarate, malate, α-ketoglutarate, cis/trans aconitate, and isocitrate. Additionally, participants underwent an assessment of liver proton-density fat fraction (PDFF) and a 3-hour oral glucose tolerance test (OGTT). Nineteen youth without obesity (BMI 21.5 ± 0.5 Kg/m2) and twenty-nine youth with obesity (BMI 37.3 ± 1.7 Kg/m2) were enrolled in the study. Youth with obesity showed higher plasma concentrations of lactate (P=0.009) and pyruvate (P=0.096) and lower plasma concentrations of fumarate (P=0.022), malate (P=0.009), cis/trans aconitate (P=0.03), and citrate/isocitrate (P=0.012). PDFF was also directly correlated with lactate (r=0.46, P=0.027). Adipose tissue insulin resistance was not associated with biomarkers of glycolysis. The metabolomic analysis revealed distinct characteristics between adolescents with and without obesity, thus demonstrating lower rates of aerobic glucose utilization in youth with obesity, which may contribute to the development of insulin resistance, type 2 diabetes, and cardiovascular disease.
DOI: 10.6084/m9.figshare.30909320
title: Supplementary Material for: Effect of Tai Chi and Qigong on Heart Rate Variability: A Systematic Review and Meta-Analysis Examining Baseline Autonomic Function and Intervention Complexity as Moderators in Adults

description: Introduction
Tai Chi and Qigong (TCQ) are mind–body practices widely recognized for their psychological benefits; however, the underlying physiological mechanisms remain less clearly defined. Time-domain heart rate variability (HRV) indices, specifically standard deviation of normal-to-normal intervals (SDNN) and root mean square of successive differences (RMSSD), serve as valuable markers of autonomic function. This meta-analysis quantified the effects of TCQ on these HRV parameters and examined whether baseline autonomic function and intervention complexity influenced outcomes.
Methods
Following PRISMA 2020 guidelines and a registered protocol (PROSPERO CRD420251053398), randomized controlled and quasi-experimental studies comparing Tai Chi and Qigong (TCQ) with control interventions in adults were systematically synthesized. Comprehensive searches were conducted in PubMed, Scopus, CINAHL Ultimate, and MEDLINE Ultimate databases from 2022 to 2025, with earlier studies identified through backward citation tracking. Eligible studies reported time-domain heart rate variability (HRV) outcomes with SDNN and RMSSD as the primary endpoints. The risk of bias was assessed using RoB 2 for randomized controlled trials and ROBINS-I for non-randomized studies. Random-effects meta-analyses were conducted to estimate Hedges’ g with 95% confidence intervals. Pre-specified moderators included baseline autonomic function and intervention complexity.
Results
Fifteen studies met the inclusion criteria, all involving participants who were naïve to Tai Chi and Qigong (TCQ). Ten studies (N = 543) provided SDNN data, and pooled analyses showed a moderate improvement with TCQ (g = 0.47, 95% CI [0.22, 0.72]; p &lt; 0.001; I² = 49%; τ² = 0.078). Four studies (N = 212) reported RMSSD data, revealing a significant increase (g = 0.60, 95% CI [0.21, 0.99]; p = 0.002; I² = 49%; τ² = 0.078). The risk of bias was generally assessed as having some concerns. Notably, baseline autonomic function significantly moderated treatment effects, with larger gains observed in participants exhibiting preserved baseline autonomic function (Q = 7.59, p = 0.014); however, intervention complexity did not significantly influence outcomes (Q = 0.02, p = 0.89).
Conclusion
TCQ was associated with moderate improvements in time-domain HRV (SDNN and RMSSD). The effects were larger at normal baseline HRV, and we found no evidence that intervention complexity modified the outcomes. The certainty of evidence is limited by the risk of bias, potential confounding, and heterogeneity. Low-complexity readiness-tailored routines may be appropriate for pilot prevention or adjunctive programs. Confirmation requires well-powered baseline-stratified trials, particularly in impaired cohorts.
DOI: 10.6084/m9.figshare.30909320.v1
title: Supplementary Material for: Effect of Tai Chi and Qigong on Heart Rate Variability: A Systematic Review and Meta-Analysis Examining Baseline Autonomic Function and Intervention Complexity as Moderators in Adults

description: Introduction
Tai Chi and Qigong (TCQ) are mind–body practices widely recognized for their psychological benefits; however, the underlying physiological mechanisms remain less clearly defined. Time-domain heart rate variability (HRV) indices, specifically standard deviation of normal-to-normal intervals (SDNN) and root mean square of successive differences (RMSSD), serve as valuable markers of autonomic function. This meta-analysis quantified the effects of TCQ on these HRV parameters and examined whether baseline autonomic function and intervention complexity influenced outcomes.
Methods
Following PRISMA 2020 guidelines and a registered protocol (PROSPERO CRD420251053398), randomized controlled and quasi-experimental studies comparing Tai Chi and Qigong (TCQ) with control interventions in adults were systematically synthesized. Comprehensive searches were conducted in PubMed, Scopus, CINAHL Ultimate, and MEDLINE Ultimate databases from 2022 to 2025, with earlier studies identified through backward citation tracking. Eligible studies reported time-domain heart rate variability (HRV) outcomes with SDNN and RMSSD as the primary endpoints. The risk of bias was assessed using RoB 2 for randomized controlled trials and ROBINS-I for non-randomized studies. Random-effects meta-analyses were conducted to estimate Hedges’ g with 95% confidence intervals. Pre-specified moderators included baseline autonomic function and intervention complexity.
Results
Fifteen studies met the inclusion criteria, all involving participants who were naïve to Tai Chi and Qigong (TCQ). Ten studies (N = 543) provided SDNN data, and pooled analyses showed a moderate improvement with TCQ (g = 0.47, 95% CI [0.22, 0.72]; p &lt; 0.001; I² = 49%; τ² = 0.078). Four studies (N = 212) reported RMSSD data, revealing a significant increase (g = 0.60, 95% CI [0.21, 0.99]; p = 0.002; I² = 49%; τ² = 0.078). The risk of bias was generally assessed as having some concerns. Notably, baseline autonomic function significantly moderated treatment effects, with larger gains observed in participants exhibiting preserved baseline autonomic function (Q = 7.59, p = 0.014); however, intervention complexity did not significantly influence outcomes (Q = 0.02, p = 0.89).
Conclusion
TCQ was associated with moderate improvements in time-domain HRV (SDNN and RMSSD). The effects were larger at normal baseline HRV, and we found no evidence that intervention complexity modified the outcomes. The certainty of evidence is limited by the risk of bias, potential confounding, and heterogeneity. Low-complexity readiness-tailored routines may be appropriate for pilot prevention or adjunctive programs. Confirmation requires well-powered baseline-stratified trials, particularly in impaired cohorts.
DOI: 10.13130/rd_unimi/zvkzj5/0wxyh2
title: Agosto_1918_Pagina_079.jpg

description: Bulletin of 1918/08/14
DOI: 10.13130/rd_unimi/cgo8lw/jnrewo
title: Agosto_1914_Pagina_088.jpg

description: Bulletin of 1914/08/15
DOI: 10.13130/rd_unimi/tdflym/wr56tf
title: Aprile_1899_Pagina_051.jpg

description: Bulletin of 1899/04/13
DOI: 10.13130/rd_unimi/zbysir/sknple
title: Agosto_1900_Pagina_115.jpg

description: Bulletin of 1900/08/29
DOI: 10.6084/m9.figshare.30909323
title: Supplementary Material for: When jack of all trades is a master of none: Comparing the performance of GPT-4 Omni against specialised neural networks in identifying malignant dermatological lesions from smartphone images and structured clinical data

description: Introduction: Artificial intelligence (AI) can potentially assist in triaging suspicious skin lesions as malignant or benign. General-purpose multimodal large language models (LLMs), such as GPT-4o, have not been rigorously evaluated for this task. This study assessed GPT-4o’s ability to triage skin lesions and compared its performance to specialised neural networks.

Methods: We evaluated GPT-4o using 1000 random cases from the PAD-UFES-20 dataset with 50 repeated trials. GPT-4o was tested using clinical data-only, image-only, and multimodal inputs. GPT-4o’s performance, consistency, and fairness across different demographic subgroups was evaluated. Its performance metrics were compared against specialised unimodal and multimodal neural networks trained on a separate subset of the PAD-UFES-20 dataset.

Results: GPT-4o exhibited poor diagnostic performance across all modalities, with average balanced accuracies of 0.571, 0.602, and 0.622 for clinical data, image, and multimodal inputs, respectively. Sensitivity was consistently high (&gt;0.95) with the tradeoff of very low specificity. Mean agreement rates were high (&gt;0.90), however Fleiss’ κ indicated only moderate consistency due to a strong bias toward malignant classifications. Fairness evaluations showed poorer discriminative performance in younger patients compared to middle-aged and elderly patients, but no notable differences between different sex and skin tone subgroups. Specialised neural networks significantly outperformed GPT-4o on most pairwise comparisons. Multimodal inputs significantly improved GPT-4o performance over unimodal inputs.

Conclusion: Although GPT-4o consistently triaged skin lesions with high sensitivity, its very low specificity limits clinical utility. Thus, general-purpose LLMs like GPT-4o are currently unsuitable for clinical dermatological diagnostics without significant field-specific developments and validation.
DOI: 10.6084/m9.figshare.30909323.v1
title: Supplementary Material for: When jack of all trades is a master of none: Comparing the performance of GPT-4 Omni against specialised neural networks in identifying malignant dermatological lesions from smartphone images and structured clinical data

description: Introduction: Artificial intelligence (AI) can potentially assist in triaging suspicious skin lesions as malignant or benign. General-purpose multimodal large language models (LLMs), such as GPT-4o, have not been rigorously evaluated for this task. This study assessed GPT-4o’s ability to triage skin lesions and compared its performance to specialised neural networks.

Methods: We evaluated GPT-4o using 1000 random cases from the PAD-UFES-20 dataset with 50 repeated trials. GPT-4o was tested using clinical data-only, image-only, and multimodal inputs. GPT-4o’s performance, consistency, and fairness across different demographic subgroups was evaluated. Its performance metrics were compared against specialised unimodal and multimodal neural networks trained on a separate subset of the PAD-UFES-20 dataset.

Results: GPT-4o exhibited poor diagnostic performance across all modalities, with average balanced accuracies of 0.571, 0.602, and 0.622 for clinical data, image, and multimodal inputs, respectively. Sensitivity was consistently high (&gt;0.95) with the tradeoff of very low specificity. Mean agreement rates were high (&gt;0.90), however Fleiss’ κ indicated only moderate consistency due to a strong bias toward malignant classifications. Fairness evaluations showed poorer discriminative performance in younger patients compared to middle-aged and elderly patients, but no notable differences between different sex and skin tone subgroups. Specialised neural networks significantly outperformed GPT-4o on most pairwise comparisons. Multimodal inputs significantly improved GPT-4o performance over unimodal inputs.

Conclusion: Although GPT-4o consistently triaged skin lesions with high sensitivity, its very low specificity limits clinical utility. Thus, general-purpose LLMs like GPT-4o are currently unsuitable for clinical dermatological diagnostics without significant field-specific developments and validation.
DOI: 10.6084/m9.figshare.30909326
title: Supplementary Material for: Leber Hereditary Optic Neuropathy-Associated Novel Mutation in MT-RNR2 Gene: A Case Report

description: Abstract

Background: Leber hereditary optic neuropathy (LHON) is a hereditary optic neuropathy mainly caused by mutations at 1178, 14484, and 3460 in mitochondrial DNA (mtDNA). Patients with LHON have a higher risk of developing multiple sclerosis (MS), a co-existence also known as Harding’s syndrome. A growing body of evidence shows that other mitochondrial and non-mitochondrial mutations can lead to LHON and Harding’s syndrome. Herein, we report a novel mutation in MT-RNR2 resulting in LHON. 
Case presentation: A 35-year-old woman with bilateral painless optic neuropathy presented to neuro-ophthalmology clinic. Her blood work-up did not reveal any nutritional deficiencies and she did not respond to steroid therapy. Genetic test revealed a m.1737A&gt;G mutation in MT-RNR2 gene with 99.9% penetrance; therefore, she was diagnosed with LHON. 
Conclusion: MT-RNR2 gene mutation was the possible cause for LHON in this patient. Herein, we describe a novel mutation and associated clinical features. This case report also underscores the importance of considering LHON as a differential diagnosis for optic neuritis, even in a patient with an established MS.
DOI: 10.13130/rd_unimi/cea2oy/4kprk8
title: Aprile_1888_Pagina_079.jpg

description: Bulletin of 1888/04/20
DOI: 10.13130/rd_unimi/i5awbn/lystyw
title: Agosto_1920_Pagina_075.jpg

description: Bulletin of 1920/08/13
DOI: 10.6084/m9.figshare.30909326.v1
title: Supplementary Material for: Leber Hereditary Optic Neuropathy-Associated Novel Mutation in MT-RNR2 Gene: A Case Report

description: Abstract

Background: Leber hereditary optic neuropathy (LHON) is a hereditary optic neuropathy mainly caused by mutations at 1178, 14484, and 3460 in mitochondrial DNA (mtDNA). Patients with LHON have a higher risk of developing multiple sclerosis (MS), a co-existence also known as Harding’s syndrome. A growing body of evidence shows that other mitochondrial and non-mitochondrial mutations can lead to LHON and Harding’s syndrome. Herein, we report a novel mutation in MT-RNR2 resulting in LHON. 
Case presentation: A 35-year-old woman with bilateral painless optic neuropathy presented to neuro-ophthalmology clinic. Her blood work-up did not reveal any nutritional deficiencies and she did not respond to steroid therapy. Genetic test revealed a m.1737A&gt;G mutation in MT-RNR2 gene with 99.9% penetrance; therefore, she was diagnosed with LHON. 
Conclusion: MT-RNR2 gene mutation was the possible cause for LHON in this patient. Herein, we describe a novel mutation and associated clinical features. This case report also underscores the importance of considering LHON as a differential diagnosis for optic neuritis, even in a patient with an established MS.
DOI: 10.13130/rd_unimi/cmir61/ap2eov
title: Aprile_1897_Pagina_070.jpg

description: Bulletin of 1897/04/18
DOI: 10.13130/rd_unimi/pddrps/70qcll
title: Agosto_1937_Pagina_001.jpg

description: Bulletin of 1937/08/01
DOI: 10.13130/rd_unimi/zbysir/svstdc
title: Agosto_1900_Pagina_116.jpg

description: Bulletin of 1900/08/29
DOI: 10.13130/rd_unimi/cea2oy/gvpjga
title: Aprile_1888_Pagina_080.jpg

description: Bulletin of 1888/04/20
DOI: 10.13130/rd_unimi/cgo8lw/cbvna7
title: Agosto_1914_Pagina_089.jpg

description: Bulletin of 1914/08/15
DOI: 10.13130/rd_unimi/zvkzj5/9nfpbm
title: Agosto_1918_Pagina_080.jpg

description: Bulletin of 1918/08/14