cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.10073669
title: Nanoparticles of Fe2O3 and Co3O4 as Efficient Electrocatalysts for Oxygen Reduction Reaction in Acid Medium

description: This paper presents a comparative study about the oxygen reduction reaction (ORR) catalyzed by nanoparticles of Fe2O3 and Co3O4 applied on the surface of glassy carbon electrodes (GCE). The nanoparticles were synthesized using the modified polymeric precursor method (Pechini). These two nanomaterials were characterized by Fourier transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD) techniques. The estimated average particle sizes were 21 and 31 nm for Fe2O3 and Co3O4, respectively. Electrochemical impedance spectroscopy (EIS) showed that Fe2O3/GCE has lower charge transfer resistance than Co3O4/GCE. The surface electrochemistry of both Fe2O3/GCE and Co3O4/GCE was studied in the solution free of O2, and their corresponding reaction mechanisms were analyzed. The electrocatalytic ORR activities of these two catalysts were studied by cyclic voltammetry (CV) and rotating disk electrode (RDE) in acidic solution. The results obtained by RDE indicated that both Fe2O3/GCE and Co3O4/GCE can catalyze the ORR with a dominating 2-electron transfer process to produce H2O2, using a potential of -0.8 V. These kinetic results indicate that Fe2O3/GCE is more efficient than Co3O4/GCE in terms of ORR. Considering the low cost of these two non-noble metal catalysts, they may be used as viable alternatives for ORR electrocatalysts.
DOI: 10.7270/q23j3d8r
title: BindingDB Entry 50032985: Identification of a new series of non-peptidic NK3 receptor antagonists.

description: Small molecule binding data for protein Neurokinin 1 receptor, Neurokinin 2 receptor, and Neurokinin 3 receptor, Uniprot P21452, P25103, and P29371
DOI: 10.7270/q2445mpj
title: BindingDB Entry 50032146: Synthesis and in vitro binding studies of piperazine-alkyl-naphthamides: impact of homology and sulphonamide/carboxamide bioisosteric replacement on the affinity for 5-HT1A, alpha2A, D4.2, D3 and D2L receptors.

description: Small molecule binding data for protein 5-hydroxytryptamine receptor 1A, Alpha-2A adrenergic receptor, Dopamine receptor, and Dopamine receptor D2L/neurotensin receptor NTS1, Uniprot P08908, P08913, P14416, and P19020
DOI: 10.7270/q26w9b57
title: BindingDB Entry 50031184: Synthesis and structure-activity relationships of N-benzyl-N-(X-2-hydroxybenzyl)-N'-phenylureas and thioureas as antitumor agents.

description: Small molecule binding data for protein Epidermal growth factor receptor and Epidermal growth factor receptor and ErbB2 (HER1 and HER2), Uniprot P00533 and P04626
DOI: 10.7270/q27081gh
title: BindingDB Entry 50030199: TBA

description: Small molecule binding data for protein Integrin alpha-L/beta-2 (LFA-1), Uniprot P20701
DOI: 10.7270/q279450g
title: BindingDB Entry 50032984: Synthesis of N-alkylated noeurostegines and evaluation of their potential as treatment for Gaucher's disease.

description: Small molecule binding data for protein Glucocerebrosidase (Acid beta-Glucosidase), Uniprot P04062
DOI: 10.7270/q2b27vk1
title: BindingDB Entry 50032991: A new structural alert for benzimidazoles: 2,6-dimethylphenyl substituents increase mutagenic potential and time-dependent CYP3A4 inhibition risk.

description: Small molecule binding data for protein Cytochrome P450 3A, Uniprot P08684
DOI: 10.7270/q2bp02w3
title: BindingDB Entry 50031183: Synthesis of glycyrrhetinic acid derivatives for the treatment of metabolic diseases.

description: Small molecule binding data for protein 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) and 11-beta-hydroxysteroid dehydrogenase 2, Uniprot P16232 and P50233
DOI: 10.7270/q2br8s6j
title: BindingDB Entry 50030198: TBA

description: Small molecule binding data for protein AVPR1A and Vasopressin V1a receptor (V1a), Uniprot P30560 and P37288
DOI: 10.7270/q2c24wqd
title: BindingDB Entry 50032983: Scaffold oriented synthesis. Part 4: design, synthesis and biological evaluation of novel 5-substituted indazoles as potent and selective kinase inhibitors employing heterocycle forming and multicomponent reactions.

description: Small molecule binding data for protein Aurora kinase B/Inner centromere protein, Epidermal growth factor receptor, Glycogen synthase kinase-3, Rho-associated protein kinase, Serine/threonine-protein kinase PAK 4, Serine/threonine-protein kinase PIM, Tyrosine-protein kinase JAK2, and Vascular endothelial growth factor receptor 2, Uniprot O60674, O75116, O96013, P00533, P11309, P35968, P49841, and Q96GD4
DOI: 10.7270/q2cn7437
title: BindingDB Entry 50032144: Structure-activity studies on acetylcholinesterase inhibition in the lycorine series of Amaryllidaceae alkaloids.

description: Small molecule binding data for protein Acetylcholinesterase, Uniprot P22303
DOI: 10.7270/q2fj2gs1
title: BindingDB Entry 50030205: TBA

description: Small molecule binding data for protein Muscarinic acetylcholine receptor M1, Muscarinic acetylcholine receptor M2, and Muscarinic acetylcholine receptor M2 and M4, Uniprot P08172, P08173, and P11229
DOI: 10.7270/q2ft8m9f
title: BindingDB Entry 50032990: Design of novel CXCR4 antagonists that are potent inhibitors of T-tropic (X4) HIV-1 replication.

description: Small molecule binding data for protein C-X-C chemokine receptor type 4 (CXCR4), Uniprot P61073
DOI: 10.7270/q2gf0tmf
title: BindingDB Entry 50031182: Design, synthesis and biological evaluation of thiazolidinone derivatives as potential EGFR and HER-2 kinase inhibitors.

description: Small molecule binding data for protein Epidermal growth factor receptor and Epidermal growth factor receptor and ErbB2 (HER1 and HER2), Uniprot P00533 and P04626
DOI: 10.7270/q2gf0tpb
title: BindingDB Entry 50032151: A mutant selective anti-estrogen is a pure antagonist on EREs and AP-1 response elements.

description: Small molecule binding data for protein Estradiol receptor alpha (ERα) and Estradiol receptor beta (ERβ), Uniprot P03372 and Q92731
DOI: 10.7270/q2gh9j05
title: BindingDB Entry 50030197: TBA

description: Small molecule binding data for protein Neurokinin 1 receptor, Uniprot P25103
DOI: 10.7270/q2hd7vvm
title: BindingDB Entry 50032143: A physical properties based approach for the exploration of a 4-hydroxybenzothiazolone series of beta2-adrenoceptor agonists as inhaled long-acting bronchodilators.

description: Small molecule binding data for protein Beta-1 adrenergic receptor and Beta-2 adrenergic receptor and beta-3 adrenergic receptor, Uniprot P07550 and P08588
DOI: 10.7270/q2k937j6
title: BindingDB Entry 50030204: TBA

description: Small molecule binding data for protein Leucine aminopeptidase (LAP)
DOI: 10.7270/q2m61kcm
title: BindingDB Entry 50031181: Aminopyridinecarboxamide-based inhibitors: Structure-activity relationship.

description: Small molecule binding data for protein Inhibitor of NF-kappa-B kinase (IKK), Uniprot O14920 and O15111
DOI: 10.7270/q2m61kfh
title: BindingDB Entry 50032150: New halogenated 3-phenylcoumarins as potent and selective MAO-B inhibitors.

description: Small molecule binding data for protein Amine oxidase [flavin-containing] A and Amine oxidase [flavin-containing] B, Uniprot P21397 and P27338
DOI: 10.7270/q2q2408x
title: BindingDB Entry 50030203: TBA

description: Small molecule binding data for protein Neurokinin 1 receptor, Uniprot P25103
DOI: 10.7270/q2q81dc5
title: BindingDB Entry 50032988: Discovery of novel positive allosteric modulators of the metabotropic glutamate receptor 5 (mGlu5).

description: Small molecule binding data for protein Metabotropic glutamate receptor 5, Uniprot P41594
DOI: 10.7270/q2qz2b2k
title: BindingDB Entry 50031180: Synthesis of theophylline derivatives and study of their activity as antagonists at adenosine receptors.

description: Small molecule binding data for protein Adenosine receptor A1, Adenosine receptor A2a, Adenosine receptor A2b, and Adenosine receptor A3, Uniprot P0DMS8, P29274, P29275, and P30542
DOI: 10.7270/q2qz2b5x
title: BindingDB Entry 50032149: Succinic acid amides as P2-P3 replacements for inhibitors of interleukin-1beta converting enzyme (ICE or caspase 1).

description: Small molecule binding data for protein Caspase-1, Uniprot P29452 and P29466
DOI: 10.7270/q2r78fgj
title: BindingDB Entry 50032980: Scaffold oriented synthesis. Part 3: design, synthesis and biological evaluation of novel 5-substituted indazoles as potent and selective kinase inhibitors employing [2+3] cycloadditions.

description: Small molecule binding data for protein Aurora kinase B/Inner centromere protein, Epidermal growth factor receptor, Glycogen synthase kinase-3, Rho-associated protein kinase, Serine/threonine-protein kinase PAK 4, Serine/threonine-protein kinase PIM, Tyrosine-protein kinase JAK2, and Vascular endothelial growth factor receptor 2, Uniprot O60674, O75116, O96013, P00533, P11309, P35968, P49841, and Q96GD4
DOI: 10.7270/q2tt4r0z
title: BindingDB Entry 50030202: TBA

description: Small molecule binding data for protein PKC alpha and beta-2, Protein kinase C delta type, Protein kinase C, epsilon, and Protein kinase C, gamma, Uniprot P05129, P05771, Q02156, and Q05655
DOI: 10.7270/q2v1252f
title: BindingDB Entry 50032987: Design, synthesis and SAR of a series of 1,3,5-trisubstituted benzenes as thrombin inhibitors.

description: Small molecule binding data for protein Prothrombin, Uniprot P00734
DOI: 10.7270/q2vm4cck
title: BindingDB Entry 50031179: Design, synthesis, and biological evaluation of 3-[4-(2-hydroxyethyl)piperazin-1-yl]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2(1H)-one, a potent, orally active, brain penetrant inhibitor of phosphodiesterase 5 (PDE5).

description: Small molecule binding data for protein Phosphodiesterase 1, Phosphodiesterase 1A (PDE1A), Phosphodiesterase 1C (PDE1C), Phosphodiesterase 3 (PDE3), Phosphodiesterase 8, Voltage-gated potassium channel, cAMP-specific 3',5'-cyclic phosphodiesterase 4A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B, cAMP-specific 3',5'-cyclic phosphodiesterase 4C, cAMP-specific 3',5'-cyclic phosphodiesterase 4D, cAMP-specific 3',5'-cyclic phosphodiesterase 7B, cGMP-inhibited 3',5'-cyclic phosphodiesterase B, and cGMP-specific 3',5'-cyclic phosphodiesterase, Uniprot O60658, O76074, O95263, P27815, P54750, Q01064, Q07343, Q08493, Q08499, Q12809, Q13370, Q14123, Q14432, and Q9NP56
DOI: 10.7270/q2vq32w7
title: BindingDB Entry 50032148: Fragment-based discovery and optimization of BACE1 inhibitors.

description: Small molecule binding data for protein Beta-secretase 1, Beta-secretase 2 (BACE2), Cathepsin D, and Voltage-gated potassium channel, Uniprot P07339, P56817, Q12809, and Q9Y5Z0
DOI: 10.7270/q2zk5gpt
title: BindingDB Entry 50030201: TBA

description: Small molecule binding data for protein HRH3, Uniprot Q9JI35
DOI: 10.7270/q2zs2ws2
title: BindingDB Entry 50032986: P3 optimization of functional potency, in vivo efficacy and oral bioavailability in 3-aminopyrazinone thrombin inhibitors bearing non-charged groups at the P1 position.

description: Small molecule binding data for protein Prothrombin, Uniprot P00734
DOI: 10.7270/q2251j90
title: BindingDB Entry 50031193: Enhancing the intestinal absorption of molecules containing the polar guanidino functionality: a double-targeted prodrug approach.

description: Small molecule binding data for protein Oligopeptide transporter small intestine isoform, Uniprot P46059
DOI: 10.7270/q22807tn
title: BindingDB Entry 50032163: Design, synthesis and anticholinesterase activity of a novel series of 1-benzyl-4-((6-alkoxy-3-oxobenzofuran-2(3H)-ylidene) methyl) pyridinium derivatives.

description: Small molecule binding data for protein Acetylcholinesterase, Uniprot O42275
DOI: 10.7270/q22b8z26
title: BindingDB Entry 50030208: TBA

description: Small molecule binding data for protein Arachidonate 15-lipoxygenase, Uniprot P16050
DOI: 10.7270/q22j6c4c
title: BindingDB Entry 50032993: Discovery of INCB10820/PF-4178903, a potent, selective, and orally bioavailable dual CCR2 and CCR5 antagonist.

description: Small molecule binding data for protein C-C chemokine receptor type 2, C-C chemokine receptor type 5, Cytochrome P450 2D6 (2D6), Cytochrome P450 3A, and Voltage-gated potassium channel, Uniprot O55193, O95950, P08684, P10635, P41597, P51681, P51682, P51683, and Q12809
DOI: 10.7270/q25b02r9
title: BindingDB Entry 50033000: Discovery ofß-aminoacyl containing thiazolidine derivatives as potent and selective dipeptidyl peptidase IV inhibitors.

description: Small molecule binding data for protein Aminopeptidase N, Dipeptidyl peptidase 4 (DPP4), Dipeptidyl peptidase II, Dipeptidyl peptidase IX, Dipeptidyl peptidase VIII, Prolyl endopeptidase, and Voltage-gated potassium channel, Uniprot O70196, P15144, P27487, Q12809, Q6V1X1, Q86TI2, and Q9EPB1
DOI: 10.7270/q25x291d
title: BindingDB Entry 50031192: Novel ester and acid derivatives of the 1,5-diarylpyrrole scaffold as anti-inflammatory and analgesic agents. Synthesis and in vitro and in vivo biological evaluation.

description: Small molecule binding data for protein Cyclooxygenase, Cyclooxygenase-1 (COX-1), Cyclooxygenase-2 (COX-2), and Prostaglandin G/H synthase (cyclooxygenase), Uniprot P22437, P23219, P35354, and Q05769
DOI: 10.7270/q2639pr2
title: BindingDB Entry 50030207: TBA

description: Small molecule binding data for protein DNA polymerase beta, Uniprot P06746
DOI: 10.7270/q26973vp
title: BindingDB Entry 50032992: Structure-activity relationship studies of sphingosine-1-phosphate receptor agonists with N-cinnamyl-ß-alanine moiety.

description: Small molecule binding data for protein Sphingosine 1-Phosphate Receptor 2, Sphingosine 1-Phosphate Receptor 5, Sphingosine 1-phosphate receptor, and Sphingosine 1-phosphate receptor 3, Uniprot O95136, P21453, Q99500, and Q9H228
DOI: 10.7270/q26w9b8k
title: BindingDB Entry 50032153: Biaryl substituted hydantoin compounds as TACE inhibitors.

description: Small molecule binding data for protein ADAM17, Uniprot P78536
DOI: 10.7270/q28w3dbn
title: BindingDB Entry 50030214: TBA

description: Small molecule binding data for protein Nociceptin/mu opioid receptor and Opioid receptors; mu & delta, Uniprot P33533 and P33535
DOI: 10.7270/q29p31rq
title: BindingDB Entry 50031191: Identification of a novel ligand binding motif in the transthyretin channel.

description: Small molecule binding data for protein TTR, Uniprot P02766
DOI: 10.7270/q29p31v2
title: BindingDB Entry 50032161: Addressing time-dependent CYP 3A4 inhibition observed in a novel series of substituted amino propanamide renin inhibitors, a case study.

description: Small molecule binding data for protein Cytochrome P450 3A and Renin, Uniprot P00797 and P08684
DOI: 10.7270/q29s1r2q
title: BindingDB Entry 50030206: TBA

description: Small molecule binding data for protein Proteinase-activated receptor 1 (PAR1), Uniprot P25116
DOI: 10.7270/q2bp02z0
title: BindingDB Entry 50032152: Hit-to-lead optimization of a series of carboxamides of ethyl 2-amino-4-phenylthiazole-5-carboxylates as novel adenosine A2A receptor antagonists.

description: Small molecule binding data for protein Adenosine receptor A1 and Adenosine receptor A2a, Uniprot P29274 and P30542
DOI: 10.7270/q2dj5fnn
title: BindingDB Entry 50030213: TBA

description: Small molecule binding data for protein Xanthine dehydrogenase, Uniprot P80457
DOI: 10.7270/q2ff3sg2
title: BindingDB Entry 50031190: Novel tumor-targeted RGD peptide-camptothecin conjugates: synthesis and biological evaluation.

description: Small molecule binding data for protein Integrin beta-3/Vitronectin receptor alpha and Integrin beta-5/Vitronectin receptor alpha, Uniprot P05106, P06756, and P18084
DOI: 10.7270/q2ff3sjz
title: BindingDB Entry 50032160: Discovery of a novel class of triazolones as checkpoint kinase inhibitors--hit to lead exploration.

description: Small molecule binding data for protein Serine/threonine-protein kinase CHK2 and Serine/threonine-protein kinase Chk1, Uniprot O14757 and O96017
DOI: 10.7270/q2j966cc
title: BindingDB Entry 50030212: TBA

description: Small molecule binding data for protein Epidermal growth factor receptor, Insulin receptor, SRC, Tyrosine-protein kinase V-ABL, Tyrosine-protein kinase transforming protein FPS, and VEGF-receptor 2 and tyrosine-protein kinase SRC, Uniprot P00521, P00530, P00533, P06213, P06239, and P12931
DOI: 10.7270/q2jm29wx
title: BindingDB Entry 50032997: 3,5-diarylazoles as novel and selective inhibitors of protein kinase D.

description: Small molecule binding data for protein CaM kinase II, Pkd1, Serine/threonine-protein kinase D1, Serine/threonine-protein kinase D2 (PKD2), and Serine/threonine-protein kinase D3, Uniprot A0A024RDK3, O94806, Q13557, Q15139, and Q9BZL6
DOI: 10.7270/q2k64j6s
title: BindingDB Entry 50031189: Biotransformation of isoimperatorin and imperatorin by Glomerella cingulata and beta-secretase inhibitory activity.

description: Small molecule binding data for protein Beta-secretase 1, Uniprot P56817
DOI: 10.7270/q2k64j8p
title: BindingDB Entry 50032159: Synthesis of a series of novel 2,4,5-trisubstituted selenazole compounds as potential PLTP inhibitors.

description: Small molecule binding data for protein Cholesteryl ester transfer protein and Phospholipid transfer protein, Uniprot P11597 and P55058
DOI: 10.7270/q2kh0nnf
title: BindingDB Entry 50032989: 6-amino-4-(pyrimidin-4-yl)pyridones: novel glycogen synthase kinase-3ß inhibitors.

description: Small molecule binding data for protein Dual specificty protein kinase CLK1 and Glycogen synthase kinase-3, Uniprot P49759 and P49841
DOI: 10.7270/q2p26z45
title: BindingDB Entry 50030211: TBA

description: Small molecule binding data for protein Monoamine oxidase, Uniprot P56560
DOI: 10.7270/q2p84c6b
title: BindingDB Entry 50032996: Synthesis of 3-phenylpyrazolopyrimidine-1,2,3-triazole conjugates and evaluation of their Src kinase inhibitory and anticancer activities.

description: Small molecule binding data for protein VEGF-receptor 2 and tyrosine-protein kinase SRC, Uniprot P12931
DOI: 10.7270/q2pz58z7
title: BindingDB Entry 50031188: Modulation of Wnt signaling through inhibition of secreted frizzled-related protein I (sFRP-1) with N-substituted piperidinyl diphenylsulfonyl sulfonamides: part II.

description: Small molecule binding data for protein Secreted frizzled-related protein 1, Uniprot Q8N474
DOI: 10.7270/q2pz591j
title: BindingDB Entry 50032158: Synthesis and SAR of novel, 4-(phenylsulfamoyl)phenylacetamide mGlu4 positive allosteric modulators (PAMs) identified by functional high-throughput screening (HTS).

description: Small molecule binding data for protein Metabotropic glutamate receptor 4 (mGluR4), Uniprot Q14833
DOI: 10.7270/q2st7pv5
title: BindingDB Entry 50030210: TBA

description: Small molecule binding data for protein EDNRA and EDNRB, Uniprot P24530, P25101, and P26684
DOI: 10.7270/q2t153xn
title: BindingDB Entry 50032995: Anti-tumor pyrimidinylpiperazines bind to the prosurvival Bcl-2 protein family member Bcl-XL.

description: Small molecule binding data for protein Bcl-xL/BAK, Uniprot Q07817
DOI: 10.7270/q2tq61nh
title: BindingDB Entry 50031187: Silicon switch approach in TRPV1 antagonist MK-056 and its analogues.

description: Small molecule binding data for protein Vanilloid receptor, Uniprot O35433
DOI: 10.7270/q2tq61rv
title: BindingDB Entry 50032157: Discovery of substituted benzyl tetrazoles as histamine H3 receptor antagonists.

description: Small molecule binding data for protein Cytochrome P450 2D6 (2D6), Cytochrome P450 3A, Histamine H1 receptor, Histamine H2 Receptor, Histamine H3 receptor, Histamine receptor (H3), and Histamine receptor (H4), Uniprot P08684, P10635, P25021, P35367, Q9H3N8, Q9QYN8, and Q9Y5N1
DOI: 10.7270/q2xk8fkw
title: BindingDB Entry 50030209: TBA

description: Small molecule binding data for protein Dopamine Transporter (DAT), Uniprot P23977
DOI: 10.7270/q2xs5vnp
title: BindingDB Entry 50032994: Trisubstituted ureas as potent and selective mPGES-1 inhibitors.

description: Small molecule binding data for protein 17-beta-Hydroxysteroid Dehydrogenase 5 (17-beta-HSD5, AKR1C3), Prostaglandin E synthase, and Thromboxane A2 Synthase (P450 TxA2), Uniprot O14684, P24557, and P42330
DOI: 10.7270/q2zc82zh
title: BindingDB Entry 50031186: Nanomolar affinity, iminosugar-based chemical probes for specific labeling of lysosomal glucocerebrosidase.

description: Small molecule binding data for protein Beta-glucosidase and Glucocerebrosidase (Acid beta-Glucosidase), Uniprot P04062 and Q9HCG7
DOI: 10.7270/q2zg6sg6
title: BindingDB Entry 50032156: Fluorescent retinoid X receptor ligands for fluorescence polarization assay.

description: Small molecule binding data for protein RXR alpha/PPAR gamma, Uniprot P19793
DOI: 10.7270/q21836kx
title: BindingDB Entry 50031202: Probes for narcotic receptor mediated phenomena. 40. N-substituted cis-4a-ethyl-1,2,3,4,4a,9a-hexahydrobenzofuro[2,3-c]pyridin-8-ols.

description: Small molecule binding data for protein Delta-type opioid receptor, Kappa-type opioid receptor, and Mu-type opioid receptor, Uniprot P35372, P41143, and P41145
DOI: 10.7270/q21c1wxz
title: BindingDB Entry 50030216: TBA

description: Small molecule binding data for protein Angiotensin-converting enzyme, Uniprot P12821
DOI: 10.7270/q21j9b1f
title: BindingDB Entry 50033001: Investigation of a novel molecular descriptor for the lead optimization of 4-aminoquinazolines as vascular endothelial growth factor receptor-2 inhibitors: application for quantitative structure-activity relationship analysis in lead optimization.

description: Small molecule binding data for protein Vascular endothelial growth factor receptor 2, Uniprot P35968
DOI: 10.7270/q2445mh9
title: BindingDB Entry 50030223: Synthesis, biological evaluation, and docking studies of N-substituted acetamidines as selective inhibitors of inducible nitric oxide synthase.

description: Small molecule binding data for protein Nitric oxide synthase, inducible and Nitric-oxide synthase (endothelial and brain), Uniprot P35228
DOI: 10.7270/q24x57x2
title: BindingDB Entry 50031201: 3-(2-Aminocarbonylphenyl)propanoic acid analogs as potent and selective EP3 receptor antagonists. Part 1: discovery and exploration of the carboxyamide side chain.

description: Small molecule binding data for protein Prostanoid EP1 Receptor, Prostanoid EP2 Receptor, Prostanoid EP3 Receptor, and Prostanoid EP4 Receptor, Uniprot P30557, P32240, P35375, and Q62053
DOI: 10.7270/q2513zdm
title: BindingDB Entry 50032171: Discovery of imidazo[1,2-b]pyridazine derivatives as IKKbeta inhibitors. Part 1: Hit-to-lead study and structure-activity relationship.

description: Small molecule binding data for protein Cyclin-dependent kinase 2, Glycogen synthase kinase-3, Inhibitor of NF-kappa-B kinase (IKK), Mitogen-activated protein kinase 10, Mitogen-activated protein kinase 14, and Pyruvate dehydrogenase kinase isoenzyme 1 (PDK1), Uniprot O14920, O15111, P24941, P49841, P53779, Q15118, and Q16539
DOI: 10.7270/q2542nnp
title: BindingDB Entry 50030215: TBA

description: Small molecule binding data for protein DNA topoisomerase I (Topo I), Uniprot P11387
DOI: 10.7270/q26110hx
title: BindingDB Entry 50032162: Structure-based design, synthesis, and biological evaluation of lipophilic-tailed monocationic inhibitors of neuronal nitric oxide synthase.

description: Small molecule binding data for protein Nitric Oxide Synthase, endothelial, Nitric Oxide Synthase, inducible, and Nitric-oxide synthase, brain, Uniprot P29473, P29476, and P29477
DOI: 10.7270/q28p60mb
title: BindingDB Entry 50031199: Recent advances in the discovery of competitive protein tyrosine phosphatase 1B inhibitors for the treatment of diabetes, obesity, and cancer.

description: Small molecule binding data for protein Protein-tyrosine phosphatase 1B, Receptor-type tyrosine-protein phosphatase beta (PTPβ), and T-cell protein-tyrosine phosphatase, Uniprot P17706, P18031, and P23467
DOI: 10.7270/q28s4q3k
title: BindingDB Entry 50032170: SAR studies of non-zinc-chelating MMP-13 inhibitors: improving selectivity and metabolic stability.

description: Small molecule binding data for protein Collagenase, Uniprot P45452