cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.30984100
title: <b>Integrative Computational Approaches, Molecular Docking, and Dynamic Simulations Reveal the Antimycobacterial Efficacy of Fisetin as a Potential Inhibitor of </b><b><i>Mycobacterium tuberculosis</i></b>

description: <i>The development of effective antitubercular drugs is necessary because tuberculosis remains a major global healthcare burden. To examine the antimycobacterial properties of fisetin, the current study used an integrated method. The </i><i>in vitro</i><i> test against </i><i>Mycobacterium tuberculosis</i><i> H37Ra demonstrated notable inhibitory effects, with an MIC of 100µg/mL and an MBC of 200µg/mL. </i><i>In silico</i><i> ADMET analysis was used to assess the drug-like characteristics and advantageous pharmacokinetic parameters to explore its molecular mechanism. Significant binding affinities were observed in docking studies against eight core proteins of </i><i>Mtb</i><i>, with protein kinase B (PknB), a crucial </i><i>Mtb</i><i> regulator of cell division and survival, showing the highest affinity. Fisetin's electron stability and reactivity were revealed by DFT research, indicating that it would be able to bind to biological targets. Specifically, the stability of the fisetin-PknB complex was verified by 100-ns-scale molecular dynamics analysis, which maintained its structure and dynamics. Fisetin was shown to have similar or even better binding qualities than the anti-tubercular medication isoniazid when those were compared using docking and MD analysis. Overall, fisetin is a potential multitarget antitubercular drug that merits additional experimental validation using an integrative approach.</i>
DOI: 10.6084/m9.figshare.30984100.v3
title: <b>Integrative Computational Approaches, Molecular Docking, and Dynamic Simulations Reveal the Antimycobacterial Efficacy of Fisetin as a Potential Inhibitor of </b><b><i>Mycobacterium tuberculosis</i></b>

description: <i>The development of effective antitubercular drugs is necessary because tuberculosis remains a major global healthcare burden. To examine the antimycobacterial properties of fisetin, the current study used an integrated method. The </i><i>in vitro</i><i> test against </i><i>Mycobacterium tuberculosis</i><i> H37Ra demonstrated notable inhibitory effects, with an MIC of 100µg/mL and an MBC of 200µg/mL. </i><i>In silico</i><i> ADMET analysis was used to assess the drug-like characteristics and advantageous pharmacokinetic parameters to explore its molecular mechanism. Significant binding affinities were observed in docking studies against eight core proteins of </i><i>Mtb</i><i>, with protein kinase B (PknB), a crucial </i><i>Mtb</i><i> regulator of cell division and survival, showing the highest affinity. Fisetin's electron stability and reactivity were revealed by DFT research, indicating that it would be able to bind to biological targets. Specifically, the stability of the fisetin-PknB complex was verified by 100-ns-scale molecular dynamics analysis, which maintained its structure and dynamics. Fisetin was shown to have similar or even better binding qualities than the anti-tubercular medication isoniazid when those were compared using docking and MD analysis. Overall, fisetin is a potential multitarget antitubercular drug that merits additional experimental validation using an integrative approach.</i>
DOI: 10.6084/m9.figshare.30984100.v2
title: <b>Integrative Computational Approaches, Molecular Docking, and Dynamic Simulations Reveal the Antimycobacterial Efficacy of Fisetin as a Potential Inhibitor of </b><b><i>Mycobacterium tuberculosis</i></b>

description: <i>The development of effective antitubercular drugs is necessary because tuberculosis remains a major global healthcare burden. To examine the antimycobacterial properties of fisetin, the current study used an integrated method. The </i><i>in vitro</i><i> test against </i><i>Mycobacterium tuberculosis</i><i> H37Ra demonstrated notable inhibitory effects, with an MIC of 100µg/mL and an MBC of 200µg/mL. </i><i>In silico</i><i> ADMET analysis was used to assess the drug-like characteristics and advantageous pharmacokinetic parameters to explore its molecular mechanism. Significant binding affinities were observed in docking studies against eight core proteins of </i><i>Mtb</i><i>, with protein kinase B (PknB), a crucial </i><i>Mtb</i><i> regulator of cell division and survival, showing the highest affinity. Fisetin's electron stability and reactivity were revealed by DFT research, indicating that it would be able to bind to biological targets. Specifically, the stability of the fisetin-PknB complex was verified by 100-ns-scale molecular dynamics analysis, which maintained its structure and dynamics. Fisetin was shown to have similar or even better binding qualities than the anti-tubercular medication isoniazid when those were compared using docking and MD analysis. Overall, fisetin is a potential multitarget antitubercular drug that merits additional experimental validation using an integrative approach.</i>
DOI: 10.5281/zenodo.18118659
title: Linked collectors and determiners for: Institut Botanic de Barcelona (IBB, CSIC-Ajuntament de Barcelona), BC-Lichenotheca.

description: Natural history specimen data linked to collectors and determiners held within, "Institut Botanic de Barcelona (IBB, CSIC-Ajuntament de Barcelona), BC-Lichenotheca". Claims or attributions were made on Bionomia by volunteer Scribes, https://bionomia.net/dataset/6aeebd1a-c3ad-4bc5-bdfe-24de0e2e9052 using specimen data from the dataset aggregated by the Global Biodiversity Information Facility, https://gbif.org/dataset/6aeebd1a-c3ad-4bc5-bdfe-24de0e2e9052. Formatted as a Frictionless Data package.
DOI: 10.5281/zenodo.18118660
title: Linked collectors and determiners for: Actualización de la taxonomía y distribución de los anfibios y reptiles de San Luis Potosí.

description: Natural history specimen data linked to collectors and determiners held within, "Actualización de la taxonomía y distribución de los anfibios y reptiles de San Luis Potosí". Claims or attributions were made on Bionomia by volunteer Scribes, https://bionomia.net/dataset/6b39bfe3-0823-4940-b991-32f6ea95bb8b using specimen data from the dataset aggregated by the Global Biodiversity Information Facility, https://gbif.org/dataset/6b39bfe3-0823-4940-b991-32f6ea95bb8b. Formatted as a Frictionless Data package.
DOI: 10.5281/zenodo.18118663
title: Linked collectors and determiners for: Redescription and generic placement of the spider Cryptachaea gigantipes (Keyserling, 1890) (Araneae: Theridiidae) and notes on related synanthropic species in Australasia.

description: Natural history specimen data linked to collectors and determiners held within, "Redescription and generic placement of the spider Cryptachaea gigantipes (Keyserling, 1890) (Araneae: Theridiidae) and notes on related synanthropic species in Australasia". Claims or attributions were made on Bionomia by volunteer Scribes, https://bionomia.net/dataset/6b412b2d-0955-4b92-b5f5-1d1d04ed3b47 using specimen data from the dataset aggregated by the Global Biodiversity Information Facility, https://gbif.org/dataset/6b412b2d-0955-4b92-b5f5-1d1d04ed3b47. Formatted as a Frictionless Data package.
DOI: 10.5281/zenodo.18118664
title: Linked collectors and determiners for: Plant collections of Department of Botany Herbarium, Ahmadu Bello University, Zaria.

description: Natural history specimen data linked to collectors and determiners held within, "Plant collections of Department of Botany Herbarium, Ahmadu Bello University, Zaria". Claims or attributions were made on Bionomia by volunteer Scribes, https://bionomia.net/dataset/6b6fb2f3-b38a-4027-b8f1-ab824238cc07 using specimen data from the dataset aggregated by the Global Biodiversity Information Facility, https://gbif.org/dataset/6b6fb2f3-b38a-4027-b8f1-ab824238cc07. Formatted as a Frictionless Data package.
DOI: 10.5281/zenodo.18118665
title: Linked collectors and determiners for: ZUEC-CRU - Coleção de Crustacea do Museu de Zoologia da UNICAMP.

description: Natural history specimen data linked to collectors and determiners held within, "ZUEC-CRU - Coleção de Crustacea do Museu de Zoologia da UNICAMP". Claims or attributions were made on Bionomia by volunteer Scribes, https://bionomia.net/dataset/6ba8e2df-519e-4fb2-84c5-d964a746f7e1 using specimen data from the dataset aggregated by the Global Biodiversity Information Facility, https://gbif.org/dataset/6ba8e2df-519e-4fb2-84c5-d964a746f7e1. Formatted as a Frictionless Data package.
DOI: 10.5281/zenodo.18118666
title: Linked collectors and determiners for: New records and range extensions of several species of native bees (Hymenoptera: Apoidea) from Mississippi.

description: Natural history specimen data linked to collectors and determiners held within, "New records and range extensions of several species of native bees (Hymenoptera: Apoidea) from Mississippi". Claims or attributions were made on Bionomia by volunteer Scribes, https://bionomia.net/dataset/6bccbb3f-e095-4f54-b1f2-a1be8837e69c using specimen data from the dataset aggregated by the Global Biodiversity Information Facility, https://gbif.org/dataset/6bccbb3f-e095-4f54-b1f2-a1be8837e69c. Formatted as a Frictionless Data package.
DOI: 10.5281/zenodo.18118669
title: Linked collectors and determiners for: Cleveland Museum of Natural History.

description: Natural history specimen data linked to collectors and determiners held within, "Cleveland Museum of Natural History". Claims or attributions were made on Bionomia by volunteer Scribes, https://bionomia.net/dataset/6c032b27-e4fe-4bc9-8f11-6b5f864910ce using specimen data from the dataset aggregated by the Global Biodiversity Information Facility, https://gbif.org/dataset/6c032b27-e4fe-4bc9-8f11-6b5f864910ce. Formatted as a Frictionless Data package.
DOI: 10.5281/zenodo.18118672
title: Linked collectors and determiners for: Two new species of freshwater crayfish of the genus Faxonius (Decapoda: Cambaridae) from the Ozark Highlands of Arkansas and Missouri.

description: Natural history specimen data linked to collectors and determiners held within, "Two new species of freshwater crayfish of the genus Faxonius (Decapoda: Cambaridae) from the Ozark Highlands of Arkansas and Missouri". Claims or attributions were made on Bionomia by volunteer Scribes, https://bionomia.net/dataset/6c711c6e-5983-41a5-9ba0-133ac3e85f4a using specimen data from the dataset aggregated by the Global Biodiversity Information Facility, https://gbif.org/dataset/6c711c6e-5983-41a5-9ba0-133ac3e85f4a. Formatted as a Frictionless Data package.
DOI: 10.5281/zenodo.18118675
title: Linked collectors and determiners for: A revision of dragon millipedes III: the new genus Gigaxytes gen. nov., with the description of three new species (Diplopoda, Polydesmida, Paradoxosomatidae).

description: Natural history specimen data linked to collectors and determiners held within, "A revision of dragon millipedes III: the new genus Gigaxytes gen. nov., with the description of three new species (Diplopoda, Polydesmida, Paradoxosomatidae)". Claims or attributions were made on Bionomia by volunteer Scribes, https://bionomia.net/dataset/6c71c062-4867-4d9d-a267-871140b8dd35 using specimen data from the dataset aggregated by the Global Biodiversity Information Facility, https://gbif.org/dataset/6c71c062-4867-4d9d-a267-871140b8dd35. Formatted as a Frictionless Data package.
DOI: 10.5281/zenodo.18118676
title: Linked collectors and determiners for: Erik Acharius lichen collection.

description: Natural history specimen data linked to collectors and determiners held within, "Erik Acharius lichen collection". Claims or attributions were made on Bionomia by volunteer Scribes, https://bionomia.net/dataset/6c781d5f-a189-497b-a78d-5c2d7b41cb6a using specimen data from the dataset aggregated by the Global Biodiversity Information Facility, https://gbif.org/dataset/6c781d5f-a189-497b-a78d-5c2d7b41cb6a. Formatted as a Frictionless Data package.
DOI: 10.5281/zenodo.18118677
title: Linked collectors and determiners for: Review of  Anasillomos  Londt, 1983 with the description of a new species (Insecta : Diptera : Asilidae).

description: Natural history specimen data linked to collectors and determiners held within, "Review of  Anasillomos  Londt, 1983 with the description of a new species (Insecta : Diptera : Asilidae)". Claims or attributions were made on Bionomia by volunteer Scribes, https://bionomia.net/dataset/6cb5f9f4-5d8f-4523-80ea-14c06f588b50 using specimen data from the dataset aggregated by the Global Biodiversity Information Facility, https://gbif.org/dataset/6cb5f9f4-5d8f-4523-80ea-14c06f588b50. Formatted as a Frictionless Data package.
DOI: 10.5281/zenodo.18118680
title: Linked collectors and determiners for: Occurrence data of Afrotropical Mydidae (Insecta: Diptera: Asiloidea).

description: Natural history specimen data linked to collectors and determiners held within, "Occurrence data of Afrotropical Mydidae (Insecta: Diptera: Asiloidea)". Claims or attributions were made on Bionomia by volunteer Scribes, https://bionomia.net/dataset/6cc9b613-5f76-4654-9270-6eed8f57a34e using specimen data from the dataset aggregated by the Global Biodiversity Information Facility, https://gbif.org/dataset/6cc9b613-5f76-4654-9270-6eed8f57a34e. Formatted as a Frictionless Data package.
DOI: 10.5281/zenodo.18118681
title: Linked collectors and determiners for: Insectos de la expedición en el páramo El Valle, Boyacá - Proyecto Boyacá BIO.

description: Natural history specimen data linked to collectors and determiners held within, "Insectos de la expedición en el páramo El Valle, Boyacá - Proyecto Boyacá BIO". Claims or attributions were made on Bionomia by volunteer Scribes, https://bionomia.net/dataset/6cc29922-6fa8-4f82-bb70-f15ffdb9f2a7 using specimen data from the dataset aggregated by the Global Biodiversity Information Facility, https://gbif.org/dataset/6cc29922-6fa8-4f82-bb70-f15ffdb9f2a7. Formatted as a Frictionless Data package.
DOI: 10.5281/zenodo.18118687
title: Linked collectors and determiners for: Duke University Herbarium Fungal Collection.

description: Natural history specimen data linked to collectors and determiners held within, "Duke University Herbarium Fungal Collection". Claims or attributions were made on Bionomia by volunteer Scribes, https://bionomia.net/dataset/6cd25714-849f-4240-a762-ef33aa2e5db5 using specimen data from the dataset aggregated by the Global Biodiversity Information Facility, https://gbif.org/dataset/6cd25714-849f-4240-a762-ef33aa2e5db5. Formatted as a Frictionless Data package.
DOI: 10.5281/zenodo.18118684
title: Linked collectors and determiners for: Colección Macroinvertebrados Acuáticos Universidad Católica de Oriente.

description: Natural history specimen data linked to collectors and determiners held within, "Colección Macroinvertebrados Acuáticos Universidad Católica de Oriente". Claims or attributions were made on Bionomia by volunteer Scribes, https://bionomia.net/dataset/6cd1212c-66ba-40ee-9295-14aee7339dd0 using specimen data from the dataset aggregated by the Global Biodiversity Information Facility, https://gbif.org/dataset/6cd1212c-66ba-40ee-9295-14aee7339dd0. Formatted as a Frictionless Data package.
DOI: 10.5281/zenodo.18118688
title: Linked collectors and determiners for: Porifera MZS.

description: Natural history specimen data linked to collectors and determiners held within, "Porifera MZS". Claims or attributions were made on Bionomia by volunteer Scribes, https://bionomia.net/dataset/6cdfe092-cd6a-4f80-8d21-523c9f4a75e8 using specimen data from the dataset aggregated by the Global Biodiversity Information Facility, https://gbif.org/dataset/6cdfe092-cd6a-4f80-8d21-523c9f4a75e8. Formatted as a Frictionless Data package.
DOI: 10.5281/zenodo.18118689
title: Linked collectors and determiners for: CAS Mammalogy (MAM).

description: Natural history specimen data linked to collectors and determiners held within, "CAS Mammalogy (MAM)". Claims or attributions were made on Bionomia by volunteer Scribes, https://bionomia.net/dataset/6ce7290f-47f6-4046-8356-371f5b6749df using specimen data from the dataset aggregated by the Global Biodiversity Information Facility, https://gbif.org/dataset/6ce7290f-47f6-4046-8356-371f5b6749df. Formatted as a Frictionless Data package.
DOI: 10.5281/zenodo.18118690
title: Linked collectors and determiners for: Entomological collections, UiB.

description: Natural history specimen data linked to collectors and determiners held within, "Entomological collections, UiB". Claims or attributions were made on Bionomia by volunteer Scribes, https://bionomia.net/dataset/6ce9819a-d82b-41e1-9059-0dd201f15993 using specimen data from the dataset aggregated by the Global Biodiversity Information Facility, https://gbif.org/dataset/6ce9819a-d82b-41e1-9059-0dd201f15993. Formatted as a Frictionless Data package.
DOI: 10.5281/zenodo.18118693
title: Linked collectors and determiners for: COR herbarium - Universidade Federal de Mato Grosso do Sul - Herbário Virtual REFLORA.

description: Natural history specimen data linked to collectors and determiners held within, "COR herbarium - Universidade Federal de Mato Grosso do Sul - Herbário Virtual REFLORA". Claims or attributions were made on Bionomia by volunteer Scribes, https://bionomia.net/dataset/6cf2d179-0e25-49e1-af67-ff2571293c63 using specimen data from the dataset aggregated by the Global Biodiversity Information Facility, https://gbif.org/dataset/6cf2d179-0e25-49e1-af67-ff2571293c63. Formatted as a Frictionless Data package.
DOI: 10.5281/zenodo.18117135
title: CT/MRI Features of Acute Pancreatitis Patients with Different Comorbidity Statuses and Their Correlation with Clinical Outcomes

description: Purpose: To explore the CT/MRI imaging Features and clinical outcomes of acute pancreatitis (AP) patients with varying comorbidity statuses.

Materials and Methods: A retrospective analysis enrolled 277 acute pancreatitis (AP) patients from the Affiliated Hospital of North Sichuan Medical College, with the study period spanning January 2020 to December 2024. Research data collected included clinical profiles, laboratory assay outcomes, radiological imaging results, Cumulative Illness Rating Scale (CIRS) scores, CIRS - comorbidity indices (CIRS - CI), and CIRS - severity indices (CIRS - SI).Patients with comorbidities were stratified by CIRS: mild (1–14 points), moderate (15–18 points), and severe (≥19 points). Imaging features, disease severity, and clinical outcomes were compared across groups, with correlations between comorbidity status, imaging findings, and clinical outcomes analyzed.

Results: Among 277 patients, only 2 patients had no comorbidities; 229 were mild, 29 moderate, and 17 severe comorbidities. On CT/MRI images, as the degree of comorbidity increased, the manifestation of AP on images became more severe. Significant differences (P<0.05) can be found in age, CIRS-SI, CIRS-CI, hospital stay duration, BISAP, APACHE II, MCTSI/MMRSI, and EPIC/EPIM scores when comparing patients with different comorbidity statuses. The severe group had higher age, BISAP, EPIC/EPIM, and MCTSI/MMRSI scores vs. mild/moderate groups (P<0.05). CIRS scores positively correlated with all above parameters, Atlanta classification, and clinical outcomes.

Conclusion: Different comorbidity statuses have varied CT/MRI  characteristics. Comorbidity status show a strong association with AP disease severity, radiological scoring results, and clinical outcomes.Patients with severe comorbidities are older, have higher CT/MRI scores, more severe disease, longer hospital stays, and poorer prognoses.
DOI: 10.5281/zenodo.18117134
title: CT/MRI Features of Acute Pancreatitis Patients with Different Comorbidity Statuses and Their Correlation with Clinical Outcomes

description: Purpose: To explore the CT/MRI imaging Features and clinical outcomes of acute pancreatitis (AP) patients with varying comorbidity statuses.

Materials and Methods: A retrospective analysis enrolled 277 acute pancreatitis (AP) patients from the Affiliated Hospital of North Sichuan Medical College, with the study period spanning January 2020 to December 2024. Research data collected included clinical profiles, laboratory assay outcomes, radiological imaging results, Cumulative Illness Rating Scale (CIRS) scores, CIRS - comorbidity indices (CIRS - CI), and CIRS - severity indices (CIRS - SI).Patients with comorbidities were stratified by CIRS: mild (1–14 points), moderate (15–18 points), and severe (≥19 points). Imaging features, disease severity, and clinical outcomes were compared across groups, with correlations between comorbidity status, imaging findings, and clinical outcomes analyzed.

Results: Among 277 patients, only 2 patients had no comorbidities; 229 were mild, 29 moderate, and 17 severe comorbidities. On CT/MRI images, as the degree of comorbidity increased, the manifestation of AP on images became more severe. Significant differences (P<0.05) can be found in age, CIRS-SI, CIRS-CI, hospital stay duration, BISAP, APACHE II, MCTSI/MMRSI, and EPIC/EPIM scores when comparing patients with different comorbidity statuses. The severe group had higher age, BISAP, EPIC/EPIM, and MCTSI/MMRSI scores vs. mild/moderate groups (P<0.05). CIRS scores positively correlated with all above parameters, Atlanta classification, and clinical outcomes.

Conclusion: Different comorbidity statuses have varied CT/MRI  characteristics. Comorbidity status show a strong association with AP disease severity, radiological scoring results, and clinical outcomes.Patients with severe comorbidities are older, have higher CT/MRI scores, more severe disease, longer hospital stays, and poorer prognoses.
DOI: 10.5281/zenodo.18118694
title: Linked collectors and determiners for: University of Michigan Museum of Zoology, Division of Mammals.

description: Natural history specimen data linked to collectors and determiners held within, "University of Michigan Museum of Zoology, Division of Mammals". Claims or attributions were made on Bionomia by volunteer Scribes, https://bionomia.net/dataset/6d2cfc0a-9903-40b8-802b-403398218e4a using specimen data from the dataset aggregated by the Global Biodiversity Information Facility, https://gbif.org/dataset/6d2cfc0a-9903-40b8-802b-403398218e4a. Formatted as a Frictionless Data package.
DOI: 10.5281/zenodo.18118695
title: Linked collectors and determiners for: Actualización y depuración de la base de datos del Herbario del Instituto de Ecología, AC, Centro Regional del Bajío. Fase 2.

description: Natural history specimen data linked to collectors and determiners held within, "Actualización y depuración de la base de datos del Herbario del Instituto de Ecología, AC, Centro Regional del Bajío. Fase 2". Claims or attributions were made on Bionomia by volunteer Scribes, https://bionomia.net/dataset/6d81e520-7adb-4470-937f-daac38fddf45 using specimen data from the dataset aggregated by the Global Biodiversity Information Facility, https://gbif.org/dataset/6d81e520-7adb-4470-937f-daac38fddf45. Formatted as a Frictionless Data package.
DOI: 10.5281/zenodo.18118696
title: Linked collectors and determiners for: Colección de Fabales del Museo Botánico CORD - IMBIV.

description: Natural history specimen data linked to collectors and determiners held within, "Colección de Fabales del Museo Botánico CORD - IMBIV". Claims or attributions were made on Bionomia by volunteer Scribes, https://bionomia.net/dataset/6df67f83-b615-448c-96d2-d315655e3e04 using specimen data from the dataset aggregated by the Global Biodiversity Information Facility, https://gbif.org/dataset/6df67f83-b615-448c-96d2-d315655e3e04. Formatted as a Frictionless Data package.