cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.12417800
title: Detection of Local Differences in Spatial Characteristics Between Two Spatiotemporal Random Fields

description: Comparing the spatial characteristics of spatiotemporal random fields is often at demand. However, the comparison can be challenging due to the high-dimensional feature and dependency in the data. We develop a new multiple testing approach to detect local differences in the spatial characteristics of two spatiotemporal random fields by taking the spatial information into account. Our method adopts a two-component mixture model for location wise <i>p</i>-values and then derives a new false discovery rate (FDR) control, called mirror procedure, to determine the optimal rejection region. This procedure is robust to model misspecification and allows for weak dependency among hypotheses. To integrate the spatial heterogeneity, we model the mixture probability as well as study the benefit if any of allowing the alternative distribution to be spatially varying. An EM-algorithm is developed to estimate the mixture model and implement the FDR procedure. We study the FDR control and the power of our new approach both theoretically and numerically, and apply the approach to compare the mean and teleconnection pattern between two synthetic climate fields. Supplementary materials for this article are available online.
DOI: 10.6084/m9.figshare.12417800.v2
title: Detection of Local Differences in Spatial Characteristics Between Two Spatiotemporal Random Fields

description: Comparing the spatial characteristics of spatiotemporal random fields is often at demand. However, the comparison can be challenging due to the high-dimensional feature and dependency in the data. We develop a new multiple testing approach to detect local differences in the spatial characteristics of two spatiotemporal random fields by taking the spatial information into account. Our method adopts a two-component mixture model for location wise <i>p</i>-values and then derives a new false discovery rate (FDR) control, called mirror procedure, to determine the optimal rejection region. This procedure is robust to model misspecification and allows for weak dependency among hypotheses. To integrate the spatial heterogeneity, we model the mixture probability as well as study the benefit if any of allowing the alternative distribution to be spatially varying. An EM-algorithm is developed to estimate the mixture model and implement the FDR procedure. We study the FDR control and the power of our new approach both theoretically and numerically, and apply the approach to compare the mean and teleconnection pattern between two synthetic climate fields. Supplementary materials for this article are available online.
DOI: 10.6084/m9.figshare.7699244
title: Additional file 7: of Exosomal FMR1-AS1 facilitates maintaining cancer stem-like cell dynamic equilibrium via TLR7/NFÎşB/c-Myc signaling in female esophageal carcinoma

description: Table S2. Information of primers and probes. (XLSX 15 kb)
DOI: 10.6084/m9.figshare.7699244.v1
title: Additional file 7: of Exosomal FMR1-AS1 facilitates maintaining cancer stem-like cell dynamic equilibrium via TLR7/NFÎşB/c-Myc signaling in female esophageal carcinoma

description: Table S2. Information of primers and probes. (XLSX 15 kb)
DOI: 10.6084/m9.figshare.7699247
title: Additional file 8: of Exosomal FMR1-AS1 facilitates maintaining cancer stem-like cell dynamic equilibrium via TLR7/NFÎşB/c-Myc signaling in female esophageal carcinoma

description: Table S3. Results of mass spectrum. (XLSX 23 kb)
DOI: 10.6084/m9.figshare.7699247.v1
title: Additional file 8: of Exosomal FMR1-AS1 facilitates maintaining cancer stem-like cell dynamic equilibrium via TLR7/NFÎşB/c-Myc signaling in female esophageal carcinoma

description: Table S3. Results of mass spectrum. (XLSX 23 kb)
DOI: 10.6084/m9.figshare.9796418
title: In vitro Bioactivity, Bio-Corrosion Resistance and Antibacterial Property of Laser Cladded HA Coatings with Different Content of ZnO on Ti-6Al-4V Substrate

description: HA/ZnO coatings with varying content of ZnO were fabricated on Ti-6Al-4V substrate to enhance its bioactivity and antibacterial ability. The main phases are identified as CaTiO3, Ca3(PO4)2, ZnTiO3 and CaO. The coatings with higher ZnO content presented smaller grain size, resulting in a higher surface free energy and better wettability. Consequently, the mineralization of the ZnO/HA coatings, especially for the higher ZnO content samples were improved, indicating better enhanced in vitro bioactivity. The ZnO-HA coated Ti-6Al-4V presented better corrosion resistance than bare Ti-6Al-4V substrate. Furthermore, better corrosion resistance was obtained by increasing ZnO content in the precursor. The antimicrobial ratio of all coatings was approximately 100%, indicating the ZnO doped HA coatings presented excellent antibacterial ability.
DOI: 10.6084/m9.figshare.9796418.v1
title: In vitro Bioactivity, Bio-Corrosion Resistance and Antibacterial Property of Laser Cladded HA Coatings with Different Content of ZnO on Ti-6Al-4V Substrate

description: HA/ZnO coatings with varying content of ZnO were fabricated on Ti-6Al-4V substrate to enhance its bioactivity and antibacterial ability. The main phases are identified as CaTiO3, Ca3(PO4)2, ZnTiO3 and CaO. The coatings with higher ZnO content presented smaller grain size, resulting in a higher surface free energy and better wettability. Consequently, the mineralization of the ZnO/HA coatings, especially for the higher ZnO content samples were improved, indicating better enhanced in vitro bioactivity. The ZnO-HA coated Ti-6Al-4V presented better corrosion resistance than bare Ti-6Al-4V substrate. Furthermore, better corrosion resistance was obtained by increasing ZnO content in the precursor. The antimicrobial ratio of all coatings was approximately 100%, indicating the ZnO doped HA coatings presented excellent antibacterial ability.
DOI: 10.6084/m9.figshare.22379468
title: RNA-seq based transcriptome analysis of murine macrophages RAW264.7 treated with multi-herbal extracts reveals immunomodulatory potential and mechanism

description: Shenling Baizhu Powder is a traditional Chinese medicine formula that has been used for thousands of years to invigorate spleen, nourish stomach and regulate immune function. The multi-herbal extracts, an improved formular from Shenling Baizhu Powder, were used in our study to investigate its immune-enhancing effects and underling mechanisms. Based on UPLC-Q-TOF-MS and SPME-GC-MS analysis, 106 chemical compounds were identified from the extracts. <i>In vitro</i> assays indicated that the extracts could promote cell proliferation and NO secretion of RAW264.7 cells. RNA-seq and RT-qPCR showed that RAW264.7 cells treated with extracts increased the expression of pro-inflammatory factors IL-1β, iNOS, TNF-α, and TGF-β. Western-Blot revealed that the extracts could significantly enhance ERK phosphorylation level, and slightly increased JNK and p38 phosphorylation levels. These data suggest that multi-herbal extracts have a potential of regulating immune response via the JNK/p38/ERK signalling of MAPK pathways in RAW264.7 cells.
DOI: 10.6084/m9.figshare.8223773
title: Recurrent biotic rebounds during the Early Triassic: biostratigraphy and temporal size variation of conodonts from the Nanpanjiang Basin, South China

description: Supplementary material
DOI: 10.6084/m9.figshare.8223773.v1
title: [Recurrent biotic rebounds during the Early Triassic: biostratigraphy and temporal size variation of conodonts from the Nanpanjiang Basin, South China

description: Supplementary material
DOI: 10.6084/m9.figshare.8223773.v2
title: Recurrent biotic rebounds during the Early Triassic: biostratigraphy and temporal size variation of conodonts from the Nanpanjiang Basin, South China

description: Supplementary material
DOI: 10.25386/genetics.7175219
title: Supplemental Material for Zeng et al., 2018

description: This supplementary file includes two Tables and three Figures
DOI: 10.25386/genetics.7175219.v1
title: Supplemental Material for Zeng et al., 2018

description: This supplementary file includes two Tables and three Figures
DOI: 10.6084/m9.figshare.13466540
title: Empirical evidence of different egg morphs that match host eggs in the brush cuckoo (<i>Cacomantis variolosus</i>)

description: One of the most efficient defences against obligate brood parasitism in birds is egg ejection, where a host recognises and removes the parasitic egg from the nest. This defence often selects for egg mimicry in parasitic species to reduce the likelihood of egg ejection. If a parasite uses multiple host species with distinctive egg types, this could lead to the evolution of egg gentes (host-specific egg types) in the parasite. There is observational evidence that the brood parasitic Brush Cuckoo (<i>Cacomantis variolosus</i>) might exhibit egg gentes, but there has been no objective study conducted to determine how closely eggs of this cuckoo species resemble those of its hosts from a bird’s visual perspective. Using objective measurements to quantify egg appearance, we found that Brush Cuckoos exhibit at least two egg morphs that closely match the eggs of two of its primary hosts in colour, luminance and volume. While the determination of actual egg gentes in the Brush Cuckoo was beyond the scope of our study, our results are a first and necessary step in determining whether egg gentes might exist in this species. We suggest at least a third egg morph matching another primary host (or at least the genus of that host) might exist, but more data would be necessary to confirm this. Additionally, we provide a mechanism researchers can use to help distinguish between Brush Cuckoo eggs that are closely matched to their host eggs for future studies in this system.
DOI: 10.6084/m9.figshare.13466540.v1
title: Empirical evidence of different egg morphs that match host eggs in the brush cuckoo (<i>Cacomantis variolosus</i>)

description: One of the most efficient defences against obligate brood parasitism in birds is egg ejection, where a host recognises and removes the parasitic egg from the nest. This defence often selects for egg mimicry in parasitic species to reduce the likelihood of egg ejection. If a parasite uses multiple host species with distinctive egg types, this could lead to the evolution of egg gentes (host-specific egg types) in the parasite. There is observational evidence that the brood parasitic Brush Cuckoo (<i>Cacomantis variolosus</i>) might exhibit egg gentes, but there has been no objective study conducted to determine how closely eggs of this cuckoo species resemble those of its hosts from a bird’s visual perspective. Using objective measurements to quantify egg appearance, we found that Brush Cuckoos exhibit at least two egg morphs that closely match the eggs of two of its primary hosts in colour, luminance and volume. While the determination of actual egg gentes in the Brush Cuckoo was beyond the scope of our study, our results are a first and necessary step in determining whether egg gentes might exist in this species. We suggest at least a third egg morph matching another primary host (or at least the genus of that host) might exist, but more data would be necessary to confirm this. Additionally, we provide a mechanism researchers can use to help distinguish between Brush Cuckoo eggs that are closely matched to their host eggs for future studies in this system.
DOI: 10.6084/m9.figshare.7699451
title: Synthesis, structure, and property of a cd(II) 3D coordinated polymer with 2-fold parallel interpenetrated network based on 5-(4-hydroxypyridinium-1-yl) isophthalic acid ligand

description: A Cd(II) coordination polymer, {[Cd(L)(1,4-bbi)<sub>0.5</sub>(H<sub>2</sub>O)]·H<sub>2</sub>O}<i><sub>n</sub></i> (<b>1</b>), where H<sub>2</sub>L = 5-(4-hydroxypyridinium-1-ylmethyl)isophthalic acid, 1,4-bbi = 1,1′-(1,4-butanediyl)bis(imidazole), has been hydrothermally synthesized and structurally characterized by X-ray diffraction analyses and further characterized by infrared spectra (IR), elemental analyses, PXRD, and thermogravimetric (TG) analyses. Compound <b>1</b> reveals a 2-fold interpenetrating 3D framework with (4·8<sup>2</sup>·10<sup>3</sup>) (4·8<sup>2</sup>) topology, and the Cd center has a distorted octahedral environment. Meanwhile, the luminescent property of the title compound (<b>1</b>) has also been investigated in detail.
DOI: 10.6084/m9.figshare.7699505.v1
title: Reduced aquaporin-1 transcript expression in colorectal carcinoma is associated with promoter hypermethylation

description: Aquaporin-1 (AQP1) is a homo-tetrameric transmembrane protein that facilitates rapid movement of water and ions across cell membranes. The clinical significance of AQP1 expression in colorectal carcinoma (CRC) is controversial. The aim of this study was to investigate the prognostic significance of AQP1 transcript expression and the association between expression and promoter methylation in normal colonic mucosa, CRC tissues and cell lines. Analysis of publicly available datasets from The Cancer Genome Atlas revealed that AQP1 expression was significantly decreased in CRC compared to normal mucosa (12.7 versus 33.3 respectively, <i>P</i> &lt; 0.0001). However, expression increased with advanced disease, being significantly higher in stage IV (17.6) compared to either stage I (11.8, <i>P</i> = 0.0039) or II (10.9; <i>P</i> = 0.0023), and in patients with lymph node metastasis compared to those without (13.9 versus 11.3 respectively, <i>P</i> = 0.0023). Elevated expression was associated with decreased overall survival with univariate (Cox Proportional Hazard Ratio 1.60, 95% confidence interval 1.05–2.42, <i>P</i> = 0.028), but not multivariable analysis when considering the confounders stage and age. Analysis of HumanMethylation450 data demonstrated that AQP1 promoter methylation was significantly increased in CRC compared to normal mucosa. Analysis of CRC tissues and cell lines strongly suggested that methylation was associated with decreased expression. <i>BRAF</i><sup>V600E</sup> mutation alone did not explain the increase in methylation. In conclusion, AQP1 transcript expression was decreased in CRC compared to normal mucosa, and this was associated with AQP1 promoter hypermethylation. AQP1 transcript expression increased with advanced disease but was not an independent prognostic indicator.
DOI: 10.6084/m9.figshare.7699505
title: Reduced aquaporin-1 transcript expression in colorectal carcinoma is associated with promoter hypermethylation

description: Aquaporin-1 (AQP1) is a homo-tetrameric transmembrane protein that facilitates rapid movement of water and ions across cell membranes. The clinical significance of AQP1 expression in colorectal carcinoma (CRC) is controversial. The aim of this study was to investigate the prognostic significance of AQP1 transcript expression and the association between expression and promoter methylation in normal colonic mucosa, CRC tissues and cell lines. Analysis of publicly available datasets from The Cancer Genome Atlas revealed that AQP1 expression was significantly decreased in CRC compared to normal mucosa (12.7 versus 33.3 respectively, <i>P</i> &lt; 0.0001). However, expression increased with advanced disease, being significantly higher in stage IV (17.6) compared to either stage I (11.8, <i>P</i> = 0.0039) or II (10.9; <i>P</i> = 0.0023), and in patients with lymph node metastasis compared to those without (13.9 versus 11.3 respectively, <i>P</i> = 0.0023). Elevated expression was associated with decreased overall survival with univariate (Cox Proportional Hazard Ratio 1.60, 95% confidence interval 1.05–2.42, <i>P</i> = 0.028), but not multivariable analysis when considering the confounders stage and age. Analysis of HumanMethylation450 data demonstrated that AQP1 promoter methylation was significantly increased in CRC compared to normal mucosa. Analysis of CRC tissues and cell lines strongly suggested that methylation was associated with decreased expression. <i>BRAF</i><sup>V600E</sup> mutation alone did not explain the increase in methylation. In conclusion, AQP1 transcript expression was decreased in CRC compared to normal mucosa, and this was associated with AQP1 promoter hypermethylation. AQP1 transcript expression increased with advanced disease but was not an independent prognostic indicator.
DOI: 10.6084/m9.figshare.24476773
title: Supplementary Table 1 from <i>Strongyloides</i> questions – a research agenda for the future

description: Ninety three Strongyloides questions, group into 13 main questions, within two themes.
DOI: 10.6084/m9.figshare.24476773.v1
title: Supplementary Table 1 from <i>Strongyloides</i> questions – a research agenda for the future

description: Ninety three Strongyloides questions, group into 13 main questions, within two themes.
DOI: 10.6084/m9.figshare.25249216
title: ScopingReview_Data.xlsx

description: <b>Arachnid-borne diseases and species diversity among vertebrate hosts: A scoping review of the global state of knowledge</b>
DOI: 10.6084/m9.figshare.25249216.v1
title: ScopingReview_Data.xlsx

description: <b>Arachnid-borne diseases and species diversity among vertebrate hosts: A scoping review of the global state of knowledge</b>
DOI: 10.6084/m9.figshare.20282155.v1
title: Additional file 1 of Optimized data-independent acquisition approach for proteomic analysis at single-cell level

description: Additional file 1. Table S1. Large amount peptide amount and peptide amount per cell. Table S2. Detail information of 30 MS runs. Table S3. Information of single-cell level co-searching libraries. Table S4. Information of ten-cell level co-searching libraries. Table S5. Identified protein groups towards library size.
DOI: 10.6084/m9.figshare.20282155
title: Additional file 1 of Optimized data-independent acquisition approach for proteomic analysis at single-cell level

description: Additional file 1. Table S1. Large amount peptide amount and peptide amount per cell. Table S2. Detail information of 30 MS runs. Table S3. Information of single-cell level co-searching libraries. Table S4. Information of ten-cell level co-searching libraries. Table S5. Identified protein groups towards library size.
DOI: 10.6084/m9.figshare.25248136
title: Data for "Recovering whole-body angular momentum and margin of stability after treadmill-induced perturbations during sloped walking in healthy young adults" by Shabnam Shokouhi

description: Data for "Recovering whole-body angular momentum and margin of stability after treadmill-induced perturbations during sloped walking in healthy young adults" by Shabnam Shokouhi
DOI: 10.6084/m9.figshare.25248136.v2
title: Data for "Recovering whole-body angular momentum and margin of stability after treadmill-induced perturbations during sloped walking in healthy young adults" by Shabnam Shokouhi

description: Data for "Recovering whole-body angular momentum and margin of stability after treadmill-induced perturbations during sloped walking in healthy young adults" by Shabnam Shokouhi
DOI: 10.6084/m9.figshare.25248136.v3
title: Data for "Recovering whole-body angular momentum and margin of stability after treadmill-induced perturbations during sloped walking in healthy young adults" by Shabnam Shokouhi

description: Data for "Recovering whole-body angular momentum and margin of stability after treadmill-induced perturbations during sloped walking in healthy young adults" by Shabnam Shokouhi
DOI: 10.6084/m9.figshare.10321295
title: Oral delivery of lycopene-loaded microemulsion for brain-targeting: preparation, characterization, pharmacokinetic evaluation and tissue distribution

description: Lycopene is considered as a promising neuroprotector with multiple bioactivities, while its therapeutic use in neurological disorders is restricted due to low solubility, instability and limited bioavailability. Our work aimed to develop lycopene-loaded microemulsion (LME) and investigate its potentials in improving bioavailability and brain-targeting efficiency following oral administration. The blank microemulsion (ME) excipients were selected based on orthogonal design and pseudo-ternary phase diagrams, and LME was prepared using the water titration method and characterized in terms of stability, droplet size distribution, zeta potential, shape and lycopene content. The optimized LME encompassed lycopene, (<i>R</i>)-(+)-limonene, Tween 80, Transcutol HP and water and lycopene content was 463.03 ± 8.96 µg/mL. This novel formulation displayed transparent appearance and satisfactory physical and chemical stabilities. It was spherical and uniform in morphology with an average droplet size of 12.61 ± 0.46 nm and a polydispersity index (PDI) of 0.086 ± 0.028. The pharmacokinetics and tissue distributions of optimized LME were evaluated in rats and mice, respectively. The pharmacokinetic study revealed a dramatic 2.10-fold enhancement of relative bioavailability with LME against the control lycopene dissolved in olive oil (LOO) dosage form in rats. Moreover, LME showed a preferential targeting distribution of lycopene toward brain in mice, with the value of drug targeting index (DTI) up to 3.45. In conclusion, the optimized LME system demonstrated excellent physicochemical properties, enhanced oral bioavailability and superior brain-targeting capability. These findings provide a basis for the applications of ME-based strategy in brain-targeted delivery via oral route, especially for poorly water-soluble drugs.
DOI: 10.6084/m9.figshare.10321295.v1
title: Oral delivery of lycopene-loaded microemulsion for brain-targeting: preparation, characterization, pharmacokinetic evaluation and tissue distribution

description: Lycopene is considered as a promising neuroprotector with multiple bioactivities, while its therapeutic use in neurological disorders is restricted due to low solubility, instability and limited bioavailability. Our work aimed to develop lycopene-loaded microemulsion (LME) and investigate its potentials in improving bioavailability and brain-targeting efficiency following oral administration. The blank microemulsion (ME) excipients were selected based on orthogonal design and pseudo-ternary phase diagrams, and LME was prepared using the water titration method and characterized in terms of stability, droplet size distribution, zeta potential, shape and lycopene content. The optimized LME encompassed lycopene, (<i>R</i>)-(+)-limonene, Tween 80, Transcutol HP and water and lycopene content was 463.03 ± 8.96 µg/mL. This novel formulation displayed transparent appearance and satisfactory physical and chemical stabilities. It was spherical and uniform in morphology with an average droplet size of 12.61 ± 0.46 nm and a polydispersity index (PDI) of 0.086 ± 0.028. The pharmacokinetics and tissue distributions of optimized LME were evaluated in rats and mice, respectively. The pharmacokinetic study revealed a dramatic 2.10-fold enhancement of relative bioavailability with LME against the control lycopene dissolved in olive oil (LOO) dosage form in rats. Moreover, LME showed a preferential targeting distribution of lycopene toward brain in mice, with the value of drug targeting index (DTI) up to 3.45. In conclusion, the optimized LME system demonstrated excellent physicochemical properties, enhanced oral bioavailability and superior brain-targeting capability. These findings provide a basis for the applications of ME-based strategy in brain-targeted delivery via oral route, especially for poorly water-soluble drugs.
DOI: 10.6084/m9.figshare.7175588.v1
title: Additional file 2: of Genome-wide analysis of the plant-specific PLATZ proteins in maize and identification of their general role in interaction with RNA polymerase III complex

description: File S1. cDNA sequences of 17 ZmPLATZs. (TXT 12 kb)