cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.23268227
title: Supplementary Material for: BIBR1532 affects endometrial cell proliferation, migration and invasion in endometriosis via telomerase inhibition and MAPK signaling

description: Objectives: The effect of telomerase inhibitor BIBR1532 on endometriotic cells was investigated to explore the inhibitory effect of targeting telomerase on endometriosis. Design: In vitro primary cell culture study. Participants/Materials: Primary endometrial cells derived from eutopic and ectopic endometrium in patients with endometriosis. Setting: University hospital. Methods: Paired eutopic and ectopic endometrial cells were collected from 6 patients from January 2018 to July 2021. A TRAP assay was performed to detect the telomerase activity of the cells. MTT, cell cycle, apoptosis, migration and invasion assays were performed to study the inhibitory effect of BIBR1532. Enrichment analysis was performed to identify the key pathways involved in endometriosis progression and telomerase action. Then, western blotting was used to investigate the expression of related proteins. Results: BIBR1532 treatment significantly inhibited the growth of eutopic and ectopic endometrial cells, with apoptosis and cell cycle signaling involved. Migration and invasion, important characteristics for the establishment of ectopic lesions, were also inhibited by BIBR1532. The MAPK signaling cascade, related to telomerase and endometriosis, was decreased in eutopic and ectopic endometrial stromal cells with the treatment of BIBR1532. Limitations: The severe side effects of telomerase inhibitors might be the main obstacle to clinical application, so it is necessary to find better drug delivery methods in vivo. Conclusions: The telomerase inhibitor BIBR1532 affects endometrial cell proliferation, migration and invasion in endometriosis.
DOI: 10.6084/m9.figshare.23268227.v1
title: Supplementary Material for: BIBR1532 affects endometrial cell proliferation, migration and invasion in endometriosis via telomerase inhibition and MAPK signaling

description: Objectives: The effect of telomerase inhibitor BIBR1532 on endometriotic cells was investigated to explore the inhibitory effect of targeting telomerase on endometriosis. Design: In vitro primary cell culture study. Participants/Materials: Primary endometrial cells derived from eutopic and ectopic endometrium in patients with endometriosis. Setting: University hospital. Methods: Paired eutopic and ectopic endometrial cells were collected from 6 patients from January 2018 to July 2021. A TRAP assay was performed to detect the telomerase activity of the cells. MTT, cell cycle, apoptosis, migration and invasion assays were performed to study the inhibitory effect of BIBR1532. Enrichment analysis was performed to identify the key pathways involved in endometriosis progression and telomerase action. Then, western blotting was used to investigate the expression of related proteins. Results: BIBR1532 treatment significantly inhibited the growth of eutopic and ectopic endometrial cells, with apoptosis and cell cycle signaling involved. Migration and invasion, important characteristics for the establishment of ectopic lesions, were also inhibited by BIBR1532. The MAPK signaling cascade, related to telomerase and endometriosis, was decreased in eutopic and ectopic endometrial stromal cells with the treatment of BIBR1532. Limitations: The severe side effects of telomerase inhibitors might be the main obstacle to clinical application, so it is necessary to find better drug delivery methods in vivo. Conclusions: The telomerase inhibitor BIBR1532 affects endometrial cell proliferation, migration and invasion in endometriosis.
DOI: 10.6084/m9.figshare.23214797
title: Might student-centered principles affect active learning and its counterpart? An empirical study of Indonesian Curriculum Implementation

description: Education 4.0 emphasizes the use of hybrid approaches in the learning process. The use of peeragogy, heutagogy, and cybergogy may engage students in the learning processes in which active learning plays a key role. This study aimed to examine the effect of the implementation of the Merdeka Curriculum on active learning practices and their relationships with hybrid activities based on hybrid learning approaches, and active learning counterparts of (1) self-regulated learning: (2) self-directed learning, and (3) self-determined learning. These relationships will be examined in Indonesian curriculum implementation in which student-centered principles are emphasized. A cross-sectional survey was conducted by collecting responses of vocational high school students on survey. The digital questionnaire was sent to 600 Indonesian students, of whom 555 completed it. The relationships among the constructs were examined using a structural equation modelling. The results showed that a curriculum emphasizing student-centered principles was fully mediated by active learning and hybrid activities to promote student self-regulated learning (SRL), self-determined learning (SDET), and self-directed learning (SDL). Active learning and hybrid activities directly affect students’ SRL, SDET, and SDL, three counterparts of active learning that form important parts of long-life learning. This model indicates that Indonesian curriculum implementation may encourage active learning and indirectly increase learner engagement, autonomy, and metacognitive development.
DOI: 10.6084/m9.figshare.23268230
title: Supplementary Material for: BIBR1532 affects endometrial cell proliferation, migration and invasion in endometriosis via telomerase inhibition and MAPK signaling

description: Objectives: The effect of telomerase inhibitor BIBR1532 on endometriotic cells was investigated to explore the inhibitory effect of targeting telomerase on endometriosis. Design: In vitro primary cell culture study. Participants/Materials: Primary endometrial cells derived from eutopic and ectopic endometrium in patients with endometriosis. Setting: University hospital. Methods: Paired eutopic and ectopic endometrial cells were collected from 6 patients from January 2018 to July 2021. A TRAP assay was performed to detect the telomerase activity of the cells. MTT, cell cycle, apoptosis, migration and invasion assays were performed to study the inhibitory effect of BIBR1532. Enrichment analysis was performed to identify the key pathways involved in endometriosis progression and telomerase action. Then, western blotting was used to investigate the expression of related proteins. Results: BIBR1532 treatment significantly inhibited the growth of eutopic and ectopic endometrial cells, with apoptosis and cell cycle signaling involved. Migration and invasion, important characteristics for the establishment of ectopic lesions, were also inhibited by BIBR1532. The MAPK signaling cascade, related to telomerase and endometriosis, was decreased in eutopic and ectopic endometrial stromal cells with the treatment of BIBR1532. Limitations: The severe side effects of telomerase inhibitors might be the main obstacle to clinical application, so it is necessary to find better drug delivery methods in vivo. Conclusions: The telomerase inhibitor BIBR1532 affects endometrial cell proliferation, migration and invasion in endometriosis.
DOI: 10.6084/m9.figshare.23268230.v1
title: Supplementary Material for: BIBR1532 affects endometrial cell proliferation, migration and invasion in endometriosis via telomerase inhibition and MAPK signaling

description: Objectives: The effect of telomerase inhibitor BIBR1532 on endometriotic cells was investigated to explore the inhibitory effect of targeting telomerase on endometriosis. Design: In vitro primary cell culture study. Participants/Materials: Primary endometrial cells derived from eutopic and ectopic endometrium in patients with endometriosis. Setting: University hospital. Methods: Paired eutopic and ectopic endometrial cells were collected from 6 patients from January 2018 to July 2021. A TRAP assay was performed to detect the telomerase activity of the cells. MTT, cell cycle, apoptosis, migration and invasion assays were performed to study the inhibitory effect of BIBR1532. Enrichment analysis was performed to identify the key pathways involved in endometriosis progression and telomerase action. Then, western blotting was used to investigate the expression of related proteins. Results: BIBR1532 treatment significantly inhibited the growth of eutopic and ectopic endometrial cells, with apoptosis and cell cycle signaling involved. Migration and invasion, important characteristics for the establishment of ectopic lesions, were also inhibited by BIBR1532. The MAPK signaling cascade, related to telomerase and endometriosis, was decreased in eutopic and ectopic endometrial stromal cells with the treatment of BIBR1532. Limitations: The severe side effects of telomerase inhibitors might be the main obstacle to clinical application, so it is necessary to find better drug delivery methods in vivo. Conclusions: The telomerase inhibitor BIBR1532 affects endometrial cell proliferation, migration and invasion in endometriosis.
DOI: 10.5281/zenodo.8045749
title: Varian CBCT resolution phantom

description: This is a Varian CBCT dataset, measured with a resolution phantom. This dataset includes reconstruction image, calibrations, and projections
DOI: 10.5281/zenodo.8045748
title: Varian CBCT resolution phantom

description: This is a Varian CBCT dataset, measured with a resolution phantom. This dataset includes reconstruction image, calibrations, and projections
DOI: 10.25901/g4d7-3j27
title: Pyrogeography: Integrating and Evaluating Existing Models of Australian Fire Regimes to Predict Climate Change Impacts
DOI: 10.6084/m9.figshare.23528667.v1
title: phylogenetic trees and alignment used for bryophyte genome project

description: This data set include the phylogenetic trees and alignment used for bryophyte genome project paper.
DOI: 10.6084/m9.figshare.23528667.v2
title: phylogenetic trees and alignment used for bryophyte genome project

description: This data set include the phylogenetic trees and alignment used for bryophyte genome project paper.
DOI: 10.4227/05/53b489c3bffe2
title: Conserving Koalas in the 21st Century: Synthesising the Dynamics of Australia’s Koala Populations
DOI: 10.6084/m9.figshare.19165373.v1
title: Caiman crocotylus - cytb

description: Cytb alignment used to estimate divergence time between populations located east and west of the Andes.
DOI: 10.34740/kaggle/dsv/3176370
title: Omicron daily cases by country (COVID-19 variant)
DOI: 10.6084/m9.figshare.19165391
title: Chelonoidis carbonaria - cytb

description: Cytb alignment used to estimate divergence time between populations located east and west of the Andes.
DOI: 10.6084/m9.figshare.19165391.v1
title: Chelonoidis carbonaria - cytb

description: Cytb alignment used to estimate divergence time between populations located east and west of the Andes.
DOI: 10.6084/m9.figshare.19165385
title: Vegetation plots of Pistacia vera woodlands in NE Iran

description: The data set includes the presence/absence of 230 plant species in 29 vegetation plots (10 m x 10 m) in <i>Pistacia vera</i> woodland remnants of northeastern Iran.
DOI: 10.6084/m9.figshare.19165385.v1
title: Vegetation plots of Pistacia vera woodlands in NE Iran

description: The data set includes the presence/absence of 230 plant species in 29 vegetation plots (10 m x 10 m) in <i>Pistacia vera</i> woodland remnants of northeastern Iran.
DOI: 10.34740/kaggle/dsv/3176441
title: Omicron daily cases by country (COVID-19 variant)
DOI: 10.5281/zenodo.6055897
title: ePharmaLib: A Versatile Library of e-Pharmacophores to Address Small-Molecule (Poly-)Pharmacology

description: <em><strong>The peer-reviewed publication for this dataset has now been published in Journal of Chemical Information and Modeling, and can be accessed here: https://doi.org/10.1021/acs.jcim.1c00135. Please cite this when using the dataset.</strong></em> <em>Reverse pharmacophore screening (parallel screening) is an efficient and cost-effective computational method used to study the polypharmacology of drugs. To this end, we created ePharmaLib: a collection of 15,148 energetically optimized, structure-based pharmacophores (e-pharmacophores) , with 3 to 8 features constituting 12.6%, 17.9%, 20.9%, 17.1%, 10.6% and 20.9%, respectively. The pharmacophores were generated from the 3D macromolecular structures of druggable proteins in complex with diverse ligands, retrieved from the sc-PDB database (http://bioinfo-pharma.u-strasbg.fr/scPDB/). ePharmaLib can either be used with the Schrödinger’s PHASE program (https://schrodinger.com/products/phase) or PHARAO, also known as Align-it (https://silicos-it.be.s3-website-eu-west-1.amazonaws.com/software/align-it/1.0.4/align-it.html). Designed for drug discovery research, this ready-to-use library could dramatically expedite drug discovery by revealing novel molecular interactions of drugs in an efficient and cost-effective manner.</em>
description: This study was supported by German Academic Exchange Service (DAAD): award No. 91653768; Baden-Württemberg Foundation: BWST_WSF-043; and German National Research Foundation (DFG): grant no. INST 37/935-1 FUGG, RTG 1976, and RTG 2202.
DOI: 10.5281/zenodo.5898112
title: ePharmaLib: A Versatile Library of e-Pharmacophores to Address Small-Molecule (Poly-)Pharmacology

description: <em><strong>The peer-reviewed publication for this dataset has now been published in Journal of Chemical Information and Modeling, and can be accessed here: https://doi.org/10.1021/acs.jcim.1c00135. Please cite this when using the dataset.</strong></em> <em>Reverse pharmacophore screening (parallel screening) is an efficient and cost-effective computational method used to study the polypharmacology of drugs. To this end, we created ePharmaLib: a collection of 15,148 energetically optimized, structure-based pharmacophores (e-pharmacophores) , with 3 to 8 features constituting 12.6%, 17.9%, 20.9%, 17.1%, 10.6% and 20.9%, respectively. The pharmacophores were generated from the 3D macromolecular structures of druggable proteins in complex with diverse ligands, retrieved from the sc-PDB database (http://bioinfo-pharma.u-strasbg.fr/scPDB/). ePharmaLib can either be used with the Schrödinger’s PHASE program (https://schrodinger.com/products/phase) or PHARAO, also known as Align-it (https://silicos-it.be.s3-website-eu-west-1.amazonaws.com/software/align-it/1.0.4/align-it.html). Designed for drug discovery research, this ready-to-use library could dramatically expedite drug discovery by revealing novel molecular interactions of drugs in an efficient and cost-effective manner.</em>
description: This study was supported by German Academic Exchange Service (DAAD): award No. 91653768; Baden-Württemberg Foundation: BWST_WSF-043; and German National Research Foundation (DFG): grant no. INST 37/935-1 FUGG, RTG 1976, and RTG 2202.
DOI: 10.6084/m9.figshare.19165397
title: Crotalus - cytb - ND2 - ND4

description: Cytb, ND2, ND4 alignment used to estimate divergence time between populations located east and west of the Andes.
DOI: 10.6084/m9.figshare.19165397.v1
title: Crotalus - cytb - ND2 - ND4

description: Cytb, ND2, ND4 alignment used to estimate divergence time between populations located east and west of the Andes.
DOI: 10.6084/m9.figshare.19165406
title: Leptodeira - cytb - ND2

description: Cytb and ND4 alignment used to estimate divergence time between populations located east and west of the Andes.
DOI: 10.6084/m9.figshare.19165406.v2
title: Leptodeira - cytb - ND2

description: Cytb and ND4 alignment used to estimate divergence time between populations located east and west of the Andes.
DOI: 10.6084/m9.figshare.19165406.v1
title: Leptodeira

description: Cytb and ND4 alignment used to estimate divergence time between populations located east and west of the Andes.
DOI: 10.5281/zenodo.6056061
title: Sample graphs and sequences for testing sequence-to-graph alignment

description: File descriptions: MHC-61.agc: 61 complete MHC sequences, including GRCh38, CHM13 and 59 haplotypes extracted from HPRC year-1 assemblies. Use AGC to extract individual haplotype sequences. MHC-57.gfa.gz: sequence graph constructed by minigraph-r434, excluding sample HG002 and HG005 C4-96.agc: 96 complete C4 sequences obtained from HPRC C4-90.gfa.gz: sequence graph extracted from the full HPRC year-1 minigraph graph around the C4A/C4B genes. The graph takes GRCh38 as the reference and excludes sample HG002, HG005 and NA19240.
DOI: 10.6084/m9.figshare.3761562.v2127
title: Online Labour Index: Measuring the Online Gig Economy for Policy and Research

description: Data repository for the data underlying the Online Labour Index. See http://ilabour.oii.ox.ac.uk online-labour-index/ for details.
DOI: 10.14272/znupabcjwdfylz-uhfffaoysa-n/chmo0000595
title: 13C nuclear magnetic resonance spectroscopy (13C NMR) ()
title: InChI=1S/C12H16O3S2/c1-15-11(14)10(12-16-5-6-17-12)8-3-2-4-9(13)7-8/h8H,2-7H2,1H3

description: dataset for 13C nuclear magnetic resonance spectroscopy (13C NMR) 13C NMR (100 MHz, Chloroform-d [77.0 ppm], ppm) δ = 211.1 (C=O), 166.4 (CO2CH3), 161.0 (C=C), 117.9 (C=C), 51.3 (CO2CH3), 45.6 (CH), 45.2 (CH2), 41.2 (CH2), 38.8 (CH2), 36.5 (CH2), 28.7 (CH2), 25.4 (CH2).
DOI: 10.14272/znupabcjwdfylz-uhfffaoysa-n/chmo0000596
title: distortionless enhancement with polarization transfer (DEPT) ()
title: InChI=1S/C12H16O3S2/c1-15-11(14)10(12-16-5-6-17-12)8-3-2-4-9(13)7-8/h8H,2-7H2,1H3

description: dataset for distortionless enhancement with polarization transfer (DEPT) 13C NMR (100 MHz, Chloroform-d [77.0 ppm], ppm) δ = 45.6.
DOI: 10.14272/znupabcjwdfylz-uhfffaoysa-n/chmo0000480
title: electron ionisation mass spectrometry (EI-MS) ()
title: InChI=1S/C12H16O3S2/c1-15-11(14)10(12-16-5-6-17-12)8-3-2-4-9(13)7-8/h8H,2-7H2,1H3

description: dataset for electron ionisation mass spectrometry (EI-MS) MS (EI, 70 eV, 40°C), m/z (%): 272 (5) [M]+, 181 (8), 131 (8), 88 (11), 86 (63), 84 (100), 69 (10). HRMS–EI (m/z) (C12H16O3S2): [M]+ calcd for 272.0535; found 272.0534.
DOI: 10.14272/znupabcjwdfylz-uhfffaoysa-n/chmo0001146
title: 1H--13C heteronuclear single quantum coherence (1H-13C HSQC) ()
title: InChI=1S/C12H16O3S2/c1-15-11(14)10(12-16-5-6-17-12)8-3-2-4-9(13)7-8/h8H,2-7H2,1H3

description: dataset for 1H--13C heteronuclear single quantum coherence (1H-13C HSQC)
DOI: 10.14272/znupabcjwdfylz-uhfffaoysa-n/chmo0001148
title: 1H--13C heteronuclear multiple bond coherence (13C-1H HMBC) ()
title: InChI=1S/C12H16O3S2/c1-15-11(14)10(12-16-5-6-17-12)8-3-2-4-9(13)7-8/h8H,2-7H2,1H3

description: dataset for 1H--13C heteronuclear multiple bond coherence (13C-1H HMBC)
DOI: 10.14272/znupabcjwdfylz-uhfffaoysa-n/chmo0000630
title: infrared absorption spectroscopy (IR) ()
title: InChI=1S/C12H16O3S2/c1-15-11(14)10(12-16-5-6-17-12)8-3-2-4-9(13)7-8/h8H,2-7H2,1H3

description: dataset for infrared absorption spectroscopy (IR) IR (ATR, ṽ) = 2945 (w), 2925 (w), 2862 (w), 1703 (vs), 1678 (vs), 1509 (vs), 1447 (w), 1430 (s), 1364 (w), 1341 (w), 1324 (w), 1303 (m), 1283 (vs), 1243 (vs), 1214 (vs), 1188 (vs), 1141 (vs), 1099 (m), 1059 (w), 1031 (w), 1003 (m), 971 (w), 937 (m), 915 (w), 869 (w), 851 (w), 818 (w), 777 (m), 726 (s), 684 (w), 647 (w), 564 (w), 510 (w), 456 (w), 432 (vw), 387 (vw) cm–1.
DOI: 10.14272/znupabcjwdfylz-uhfffaoysa-n/chmo0001150
title: 1H--1H correlation spectroscopy (1H-1H COSY) ()
title: InChI=1S/C12H16O3S2/c1-15-11(14)10(12-16-5-6-17-12)8-3-2-4-9(13)7-8/h8H,2-7H2,1H3

description: dataset for 1H--1H correlation spectroscopy (1H-1H COSY)
DOI: 10.14272/znupabcjwdfylz-uhfffaoysa-n/chmo0000596.1
title: distortionless enhancement with polarization transfer (DEPT) ()
title: InChI=1S/C12H16O3S2/c1-15-11(14)10(12-16-5-6-17-12)8-3-2-4-9(13)7-8/h8H,2-7H2,1H3

description: dataset for distortionless enhancement with polarization transfer (DEPT) 13C NMR (100 MHz, Chloroform-d [77.0 ppm], ppm) δ = 51.3 (+), 45.6 (+), 45.2 (–), 41.1 (–), 38.8 (–), 36.5 (–), 28.7 (–), 25.3 (–).
DOI: 10.14272/znupabcjwdfylz-uhfffaoysa-n/chmo0000593
title: 1H nuclear magnetic resonance spectroscopy (1H NMR) ()
title: InChI=1S/C12H16O3S2/c1-15-11(14)10(12-16-5-6-17-12)8-3-2-4-9(13)7-8/h8H,2-7H2,1H3

description: dataset for 1H nuclear magnetic resonance spectroscopy (1H NMR) 1H NMR (400 MHz, Chloroform-d [7.27 ppm], ppm) δ = 3.78 (s, 3H), 3.41–3.34 (m, 4H), 3.10–3.02 (m, 1H), 2.99–2.92 (m, 1H), 2.41–2.27 (m, 3H), 2.21–2.04 (m, 2H), 1.82–1.78 (m, 1H), 1.71–1.60 (m, 1H).
DOI: 10.14272/znupabcjwdfylz-uhfffaoysa-n.1
title: methyl 2-(1,3-dithiolan-2-ylidene)-2-(3-oxocyclohexyl)acetate
title: InChI=1S/C12H16O3S2/c1-15-11(14)10(12-16-5-6-17-12)8-3-2-4-9(13)7-8/h8H,2-7H2,1H3

description: This dataset contains experimental data from a sample (InChI=1S/C12H16O3S2/c1-15-11(14)10(12-16-5-6-17-12)8-3-2-4-9(13)7-8/h8H,2-7H2,1H3). The datasets from the following experiments are available: infrared absorption spectroscopy (IR) 1H nuclear magnetic resonance spectroscopy (1H NMR) 13C nuclear magnetic resonance spectroscopy (13C NMR) distortionless enhancement with polarization transfer (DEPT) distortionless enhancement with polarization transfer (DEPT) electron ionisation mass spectrometry (EI-MS) 1H--1H correlation spectroscopy (1H-1H COSY) 1H--13C heteronuclear single quantum coherence (1H-13C HSQC) 1H--13C heteronuclear multiple bond coherence (13C-1H HMBC)
DOI: 10.34740/kaggle/dsv/3176689
title: US counties COVID 19 dataset
DOI: 10.6084/m9.figshare.19165445
title: PROFHHVALIDATIONSTUD_DATA_LABELS_2022-02-12_1611.csv

description: baseline clinical characteristics of patients in the proFHH validation study<br>
DOI: 10.6084/m9.figshare.19165445.v1
title: PROFHHVALIDATIONSTUD_DATA_LABELS_2022-02-12_1611.csv

description: baseline clinical characteristics of patients in the proFHH validation study<br>
DOI: 10.5281/zenodo.6056333
title: Data and code for "Multi-omics Reveals Microbiome, Host Gene Expression, and Immune Landscape in Gastric Carcinogenesis" by Park et al., iScience 2022

description: This repository is a part of the supplementary document in Park et al., "Multi-omics Reveals Microbiome, Host Gene Expression, and Immune Landscape in Gastric Carcinogenesis" published in iScience 2022. Abstract: To date, there has been no multi-omic analysis characterizing the intricate relationships between the intragastric microbiome and gastric mucosal gene expression in gastric carcinogenesis. Using multi-omic approaches, we provide a comprehensive view of the connections between the microbiome and host gene expression in distinct stages of gastric carcinogenesis (i.e., healthy, gastritis, cancer). We uncover associations specific to disease states. For example, uniquely in gastritis, Helicobacteraceae is highly correlated with the expression of <em>FAM3D</em>, which has been previously implicated in gastrointestinal inflammation. Additionally, in gastric cancer but not in adjacent gastritis, Lachnospiraceae is highly correlated with the expression of <em>UBD</em>, which regulates mitosis and cell cycle time. Furthermore, lower abundances of B cells in gastric cancer compared to gastritis may suggest a previously unidentified immune evasion process in gastric carcinogenesis. Our integrative analysis provides the most comprehensive description of microbial, host transcriptomic, and immune cell factors of the gastric carcinogenesis pathway.