cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.17632/3jchc2mkbf
title: Biomaterial-based 3D human lung models replicate pathological characteristics of early pulmonary fibrosis

description: Idiopathic pulmonary fibrosis (IPF) is a progressive and incurable lung disease characterized by tissue scarring that disrupts gas exchange. Epithelial cell dysfunction, fibroblast activation, and excessive extracellular matrix deposition drive this pathology that ultimately leads to respiratory failure. Mechanistic studies have shown that repeated injury to alveolar epithelial cells initiates an aberrant wound-healing response in surrounding fibroblasts through secretion of mediators like transforming growth factor-β, yet the precise biological pathways contributing to disease progression are not fully understood. To better study these interactions there is a critical need for lung models that replicate the cellular heterogeneity, geometry, and biomechanics of the distal lung microenvironment. In this study, induced pluripotent stem cell-derived alveolar epithelial type II (iATII) cells and human pulmonary fibroblasts were arranged to replicate human lung micro-architecture and embedded in soft or stiff poly(ethylene glycol) norbornene (PEG-NB) hydrogels that recapitulated the mechanical properties of healthy and fibrotic lung tissue, respectively. The co-cultured cells were then exposed to pro-fibrotic biochemical cues, including inflammatory cytokines and growth factors. iATIIs and fibroblasts exhibited differentiation pathways and gene expression patterns consistent with trends observed during IPF progression in vivo. A design of experiments statistical analysis identified stiff hydrogels combined with pro-fibrotic biochemical cue exposure as the most effective condition for modeling fibrosis in vitro. Finally, treatment with Nintedanib, one of only two Food and Drug Administration (FDA)-approved drugs for IPF, was assessed. Treatment reduced fibroblast activation, as indicated by downregulation of key activation genes, and upregulated several epithelial genes. These findings demonstrate that human 3D co-culture models hold tremendous potential for advancing our understanding of IPF and identifying novel therapeutic targets.
DOI: 10.17632/bsvj6x9fhh.2
title: Sentiment Analysis Dataset: User Reviews of New & Refurbished iPads on Amazon

description: The dataset consists of 13,862 customer reviews across 224 models of new and Refurbished iPads, which were extracted from Amazon using the Selenium WebDriver in a Java environment.
DOI: 10.17632/3jchc2mkbf.2
title: Biomaterial-based 3D human lung models replicate pathological characteristics of early pulmonary fibrosis

description: Idiopathic pulmonary fibrosis (IPF) is a progressive and incurable lung disease characterized by tissue scarring that disrupts gas exchange. Epithelial cell dysfunction, fibroblast activation, and excessive extracellular matrix deposition drive this pathology that ultimately leads to respiratory failure. Mechanistic studies have shown that repeated injury to alveolar epithelial cells initiates an aberrant wound-healing response in surrounding fibroblasts through secretion of mediators like transforming growth factor-β, yet the precise biological pathways contributing to disease progression are not fully understood. To better study these interactions there is a critical need for lung models that replicate the cellular heterogeneity, geometry, and biomechanics of the distal lung microenvironment. In this study, induced pluripotent stem cell-derived alveolar epithelial type II (iATII) cells and human pulmonary fibroblasts were arranged to replicate human lung micro-architecture and embedded in soft or stiff poly(ethylene glycol) norbornene (PEG-NB) hydrogels that recapitulated the mechanical properties of healthy and fibrotic lung tissue, respectively. The co-cultured cells were then exposed to pro-fibrotic biochemical cues, including inflammatory cytokines and growth factors. iATIIs and fibroblasts exhibited differentiation pathways and gene expression patterns consistent with trends observed during IPF progression in vivo. A design of experiments statistical analysis identified stiff hydrogels combined with pro-fibrotic biochemical cue exposure as the most effective condition for modeling fibrosis in vitro. Finally, treatment with Nintedanib, one of only two Food and Drug Administration (FDA)-approved drugs for IPF, was assessed. Treatment reduced fibroblast activation, as indicated by downregulation of key activation genes, and upregulated several epithelial genes. These findings demonstrate that human 3D co-culture models hold tremendous potential for advancing our understanding of IPF and identifying novel therapeutic targets.
DOI: 10.15468/dl.6a44h8
title: Occurrence Download

description: A dataset containing 95 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Heliophila pubescens"
 ]
}

 The dataset includes 95 records from 21 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0001119-250717081556266/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.zdnpxa
title: Occurrence Download

description: A dataset containing 514937 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Mentha arvensis vulgaris, Mentha arvensis agrestis, Mentha arvensis austriaca, Origanum vulgare, Origanum creticum, Origanum floridum, Origanum purpurascens, Origanum wallichianum, Thymus origanum, Paris quadrifolia)",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 {
 "not" : {
 "BasisOfRecord" : [
 "is one of (Fossil, Living Specimen, Machine Observation)"
 ]
 }
 },
 "Continent is Europe",
 "Year is greater than or equal to 1980",
 "Year is less than or equal to 2024"
 ]
}

 The dataset includes 514937 records from 2149 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0001041-250717081556266/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.5517/cc5vpg4
title: CCDC 174606: Experimental Crystal Structure Determination

description: Related Article: C.von Hanisch, O.Hampe|2002|Angew.Chem.,Int.Ed.|41|2095|doi:10.1002/1521-3773(20020617)41:12<2095::AID-ANIE2095>3.0.CO;2-4
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/cc5wn3s
title: CCDC 175525: Experimental Crystal Structure Determination

description: Related Article: B.Stibr, O.L.Tok, W.Milius, M.Bakardjiev, J.Holub, D.Hnyk, B.Wrackmeyer|2002|Angew.Chem.,Int.Ed.|41|2126|doi:10.1002/1521-3773(20020617)41:12<2126::AID-ANIE2126>3.0.CO;2-6
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/cc5s79g
title: CCDC 172245: Experimental Crystal Structure Determination

description: Related Article: E.Mainetti, V.Mouries, L.Fensterbank, M.Malacria, J.Marco-Contelles|2002|Angew.Chem.,Int.Ed.|41|2132|doi:10.1002/1521-3773(20020617)41:12<2132::AID-ANIE2132>3.0.CO;2-S
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/cc5x7w5
title: CCDC 176107: Experimental Crystal Structure Determination

description: Related Article: D.G.H.Hetterscheid, J.Kaiser, E.Reijerse, T.P.J.Peters, S.Thewissen, A.N.J.Blok, J.M.M.Smits, R.de Gelder, B.de Bruin|2005|J.Am.Chem.Soc.|127|1895|doi:10.1021/ja0439470
description: Related Article: B.de Bruin, T.P.J.Peters, S.Thewissen, A.N.J.Blok, J.B.M.Wilting, R.de Gelder, J.M.M.Smits, A.W.Gal|2002|Angew.Chem.,Int.Ed.|41|2135|doi:10.1002/1521-3773(20020617)41:12<2135::AID-ANIE2135>3.0.CO;2-A
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/cc5x7x6
title: CCDC 176108: Experimental Crystal Structure Determination

description: Related Article: D.G.H.Hetterscheid, J.Kaiser, E.Reijerse, T.P.J.Peters, S.Thewissen, A.N.J.Blok, J.M.M.Smits, R.de Gelder, B.de Bruin|2005|J.Am.Chem.Soc.|127|1895|doi:10.1021/ja0439470
description: Related Article: B.de Bruin, T.P.J.Peters, S.Thewissen, A.N.J.Blok, J.B.M.Wilting, R.de Gelder, J.M.M.Smits, A.W.Gal|2002|Angew.Chem.,Int.Ed.|41|2135|doi:10.1002/1521-3773(20020617)41:12<2135::AID-ANIE2135>3.0.CO;2-A
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/cc5vm3q
title: CCDC 174533: Experimental Crystal Structure Determination

description: Related Article: P.Ovejero, M.Cano, E.Pinilla, M.R.Torres|2002|Helv.Chim.Acta|85|1686|doi:10.1002/1522-2675(200206)85:6<1686::AID-HLCA1686>3.0.CO;2-P
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/cc5yhsc
title: CCDC 177313: Experimental Crystal Structure Determination

description: Related Article: T.Afrati, C.Dendrinou-Samara, C.P.Raptopoulou, A.Terzis, V.Tangoulis, D.P.Kessissoglou|2002|Angew.Chem.,Int.Ed.|41|2148|doi:10.1002/1521-3773(20020617)41:12<2148::AID-ANIE2148>3.0.CO;2-R
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/cc5xc0f
title: CCDC 176204: Experimental Crystal Structure Determination

description: Related Article: C.Ensch, M.Hesse|2002|Helv.Chim.Acta|85|1659|doi:10.1002/1522-2675(200206)85:6<1659::AID-HLCA1659>3.0.CO;2-D
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/cc5wk4q
title: CCDC 175433: Experimental Crystal Structure Determination

description: Related Article: Dacriyanus, Salni, M.V.Sargent, B.W.Skelton, I.Soediro, M.Sutisna, A.H.White, E.Yulinah|2002|Aust.J.Chem.|55|229|doi:10.1071/CH01194
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/cc662r6
title: CCDC 184597: Experimental Crystal Structure Determination

description: Related Article: Sheng-Hong Li, Hong-Jie Zhang, Sheng-Xiang Qiu, Xue-Mei Niu, B.D.Santarsiero, A.D.Mesecar, H.H.S.Fong, N.R.Farnsworth, Han-Dong Sun|2002|Tetrahedron Lett.|43|5131|doi:10.1016/S0040-4039(02)00981-4
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/cc5vf8p
title: CCDC 174352: Experimental Crystal Structure Determination

description: Related Article: J.Baldamus, G.B.Deacon, E.Hey-Hawkins, P.C.Junk, C.Martin|2002|Aust.J.Chem.|55|195|doi:10.1071/CH02039
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/cc67d3x
title: CCDC 185848: Experimental Crystal Structure Determination

description: Related Article: M.G.Banwell, A.J.Edwards, J.N.Lambert, Xing Hua Ma, K.G.Watson|2002|Aust.J.Chem.|55|95|doi:10.1071/CH02041
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/cc67d4y
title: CCDC 185849: Experimental Crystal Structure Determination

description: Related Article: M.G.Banwell, A.J.Edwards, J.N.Lambert, Xing Hua Ma, K.G.Watson|2002|Aust.J.Chem.|55|95|doi:10.1071/CH02041
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/cc62nc8
title: CCDC 181299: Experimental Crystal Structure Determination

description: Related Article: Shang-Shing P.Chou, Pi-Wei Liang|2002|Tetrahedron Lett.|43|4865|doi:10.1016/S0040-4039(02)00883-3
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/cc62nd9
title: CCDC 181300: Experimental Crystal Structure Determination

description: Related Article: Shang-Shing P.Chou, Pi-Wei Liang|2002|Tetrahedron Lett.|43|4865|doi:10.1016/S0040-4039(02)00883-3
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/cc62nfb
title: CCDC 181301: Experimental Crystal Structure Determination

description: Related Article: Shang-Shing P.Chou, Pi-Wei Liang|2002|Tetrahedron Lett.|43|4865|doi:10.1016/S0040-4039(02)00883-3
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/cc62tcf
title: CCDC 181454: Experimental Crystal Structure Determination

description: Related Article: Shang-Shing P.Chou, Pi-Wei Liang|2002|Tetrahedron Lett.|43|4865|doi:10.1016/S0040-4039(02)00883-3
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/cc5xvnk
title: CCDC 176689: Experimental Crystal Structure Determination

description: Related Article: H.Oshida, A.Ishii, J.Nakayama|2002|Tetrahedron Lett.|43|5033|doi:10.1016/S0040-4039(02)01014-6
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/cc5xvpl
title: CCDC 176690: Experimental Crystal Structure Determination

description: Related Article: H.Oshida, A.Ishii, J.Nakayama|2002|Tetrahedron Lett.|43|5033|doi:10.1016/S0040-4039(02)01014-6
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/cc5xvqm
title: CCDC 176691: Experimental Crystal Structure Determination

description: Related Article: H.Oshida, A.Ishii, J.Nakayama|2002|Tetrahedron Lett.|43|5033|doi:10.1016/S0040-4039(02)01014-6
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/cc5js6n
title: CCDC 165081: Experimental Crystal Structure Determination

description: Related Article: S.Yu.Ketkov, G.K.Fukin, L.N.Zakharov, J.C.Green, G.Clancy|2002|J.Organomet.Chem.|649|100|doi:10.1016/S0022-328X(02)01128-2
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/cc5zwgg
title: CCDC 178636: Experimental Crystal Structure Determination

description: Related Article: K.Denk, P.Sirsch, W.A.Herrmann|2002|J.Organomet.Chem.|649|219|doi:10.1016/S0022-328X(02)01133-6
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/cc5xwkh
title: CCDC 176717: Experimental Crystal Structure Determination

description: Related Article: W.A.Herrmann, P.Harter, C.W.K.Gstottmayr, F.Bielert, N.Seeboth, P.Sirsch|2002|J.Organomet.Chem.|649|141|doi:10.1016/S0022-328X(02)01110-5
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/cc5xwlj
title: CCDC 176718: Experimental Crystal Structure Determination

description: Related Article: W.A.Herrmann, P.Harter, C.W.K.Gstottmayr, F.Bielert, N.Seeboth, P.Sirsch|2002|J.Organomet.Chem.|649|141|doi:10.1016/S0022-328X(02)01110-5
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/cc5wv3z
title: CCDC 175711: Experimental Crystal Structure Determination

description: Related Article: O.Kadkin, C.Nather, W.Friedrichsen|2002|J.Organomet.Chem.|649|161|doi:10.1016/S0022-328X(02)01113-0
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/cc5wv40
title: CCDC 175712: Experimental Crystal Structure Determination

description: Related Article: O.Kadkin, C.Nather, W.Friedrichsen|2002|J.Organomet.Chem.|649|161|doi:10.1016/S0022-328X(02)01113-0
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/cc5wsd6
title: CCDC 175658: Experimental Crystal Structure Determination

description: Related Article: N.J.Long, A.J.P.White, D.J.Williams, M.Younus|2002|J.Organomet.Chem.|649|94|doi:10.1016/S0022-328X(02)01131-2
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/cc5wsg8
title: CCDC 175660: Experimental Crystal Structure Determination

description: Related Article: N.J.Long, A.J.P.White, D.J.Williams, M.Younus|2002|J.Organomet.Chem.|649|94|doi:10.1016/S0022-328X(02)01131-2
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.25549/annis-ouc17193940
title: Front, Antigua Guatemala Cathedral, Antigua, Guatemala, 1945

description: "Façade, details & 1st story, Cathedral of Antigua," Antigua, Sacatepéquez, Guatemala, 1945.