cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.10263080
title: Data for figures of“Initial cost barrier of ammonia control in central China”in GRL

description: This is the data corresponding to figures of “Initial cost barrier of ammonia control in central China” in Geophysical Research Letters.
DOI: 10.6084/m9.figshare.25231568
title: SUD Raw data.zip

description: The transient receptor potential melastatin 7 channels (TRPM7), a non-selected cations ion channel, exhibite high expression in some human cancer tissues and involved in proliferation, migration, invasion and EMT etc. of cancer cells. As a good therapeutic target of cancer, the lack of efficient and highly selective TRPM7 modulations is a big issue. N- [ 4- (4, 6- dimethyl- 2- pyrimidinyloxy) - 3- methylphenyl] -N' - [ 2 -(dimethylamino)] benzoylurea (SUD) is a newly synthesized benzoylurea derivative. Our previous studies proved that SUD inhibited the growth through inducing cell-cycle arrest and apoptosis in MCF-7 and BGC-823 cell lines. In this study, we checked the effect of SUD on the migration of cancer cells by trans-well assay and wound-healing. The results show that SUD decrease the migration of breast cancer (MCF-7) and gastric cancer (BGC-823) cells significantly both in the conditions incubated with and without EGF. In addition, we test the expression of Epithelial mesenchymal transition (EMT)-related proteins by western blot and RT-PCR. SUD decrease the expression of vimentin and increased the expression of E-cadherin in MCF-7 and BGC-823 cells, means EMT also be decreased by SUD. TRPM7 play important roles in the migration induced by EGF as we reported. So, we tested the effect of SUD on TRPM7 current and expression through Patch clamp and qPCR. We found that SUD not only reduced the TRPM7 current amplitude through direct binding to the channel, but also decreased the expression through PI3K/Akt signaling pathway. At last, we try to predicted the binding site of SUD on TRPM7 by Molecular docking analysis, which should provide some clues for new TRPM7 inhibitor found. In summary, our research demonstrated that SUD is an effective TRPM7 inhibitor and a potential agents to suppress metastasis of breast and gastric cancer through inhibit TRPM7 expression and function.
DOI: 10.6084/m9.figshare.25231568.v1
title: SUD Raw data.zip

description: The transient receptor potential melastatin 7 channels (TRPM7), a non-selected cations ion channel, exhibite high expression in some human cancer tissues and involved in proliferation, migration, invasion and EMT etc. of cancer cells. As a good therapeutic target of cancer, the lack of efficient and highly selective TRPM7 modulations is a big issue. N- [ 4- (4, 6- dimethyl- 2- pyrimidinyloxy) - 3- methylphenyl] -N' - [ 2 -(dimethylamino)] benzoylurea (SUD) is a newly synthesized benzoylurea derivative. Our previous studies proved that SUD inhibited the growth through inducing cell-cycle arrest and apoptosis in MCF-7 and BGC-823 cell lines. In this study, we checked the effect of SUD on the migration of cancer cells by trans-well assay and wound-healing. The results show that SUD decrease the migration of breast cancer (MCF-7) and gastric cancer (BGC-823) cells significantly both in the conditions incubated with and without EGF. In addition, we test the expression of Epithelial mesenchymal transition (EMT)-related proteins by western blot and RT-PCR. SUD decrease the expression of vimentin and increased the expression of E-cadherin in MCF-7 and BGC-823 cells, means EMT also be decreased by SUD. TRPM7 play important roles in the migration induced by EGF as we reported. So, we tested the effect of SUD on TRPM7 current and expression through Patch clamp and qPCR. We found that SUD not only reduced the TRPM7 current amplitude through direct binding to the channel, but also decreased the expression through PI3K/Akt signaling pathway. At last, we try to predicted the binding site of SUD on TRPM7 by Molecular docking analysis, which should provide some clues for new TRPM7 inhibitor found. In summary, our research demonstrated that SUD is an effective TRPM7 inhibitor and a potential agents to suppress metastasis of breast and gastric cancer through inhibit TRPM7 expression and function.
DOI: 10.6084/m9.figshare.7641509
title: MOESM5 of Comparative transcriptome analysis of a long-time span two-step culture process reveals a potential mechanism for astaxanthin and biomass hyper-accumulation in Haematococcus pluvialis JNU35

description: Additional file 5: Table S5. The relevant genes involved in photosynthesis.
DOI: 10.6084/m9.figshare.7641503.v1
title: MOESM4 of Comparative transcriptome analysis of a long-time span two-step culture process reveals a potential mechanism for astaxanthin and biomass hyper-accumulation in Haematococcus pluvialis JNU35

description: Additional file 4: Table S4. The relevant genes involved in astaxanthin biosynthesis.
DOI: 10.6084/m9.figshare.7641512.v1
title: MOESM6 of Comparative transcriptome analysis of a long-time span two-step culture process reveals a potential mechanism for astaxanthin and biomass hyper-accumulation in Haematococcus pluvialis JNU35

description: Additional file 6: Table S6. The relevant genes involved in nitrogen metabolism.
DOI: 10.6084/m9.figshare.7641485
title: MOESM2 of Comparative transcriptome analysis of a long-time span two-step culture process reveals a potential mechanism for astaxanthin and biomass hyper-accumulation in Haematococcus pluvialis JNU35

description: Additional file 2: Table S2. Significantly enriched GO terms in the set of 6 profiles (p-value 0.05).
DOI: 10.6084/m9.figshare.7641494
title: MOESM3 of Comparative transcriptome analysis of a long-time span two-step culture process reveals a potential mechanism for astaxanthin and biomass hyper-accumulation in Haematococcus pluvialis JNU35

description: Additional file 3: Table S3. The KEGG pathway of significantly expression pattern.
DOI: 10.6084/m9.figshare.7641503
title: MOESM4 of Comparative transcriptome analysis of a long-time span two-step culture process reveals a potential mechanism for astaxanthin and biomass hyper-accumulation in Haematococcus pluvialis JNU35

description: Additional file 4: Table S4. The relevant genes involved in astaxanthin biosynthesis.
DOI: 10.6084/m9.figshare.7641473
title: Additional file 1: of Proteomic dissection of the rice-Fusarium fujikuroi interaction and the correlation between the proteome and transcriptome under disease stress

description: The total proteins and DEPs of 93-11 and Nipponbare. (XLSX 9906 kb)
DOI: 10.6084/m9.figshare.14457084
title: Additional file 1 of SNRPD1 confers diagnostic and therapeutic values on breast cancers through cell cycle regulation

description: Additional file 1: Table S1. Information on siRNAs purchased for knocking down SNRPD1 in the study. Table S2. Information on the qPCR primers used in the experiment. Table S3. Information of 434 SRTNS from data analysis using protein MS data. Table S. Key cell cycle related Reactome pathways enriched by 434 SRTNS. The prediction was conducted using STRING. Table S5. Expansion of abbreviations in Fig. 2a.
DOI: 10.6084/m9.figshare.7641473.v1
title: Additional file 1: of Proteomic dissection of the rice-Fusarium fujikuroi interaction and the correlation between the proteome and transcriptome under disease stress

description: The total proteins and DEPs of 93-11 and Nipponbare. (XLSX 9906 kb)
DOI: 10.6084/m9.figshare.7641662
title: Additional file 2: of Aerobic prokaryotes do not have higher GC contents than anaerobic prokaryotes, but obligate aerobic prokaryotes have

description: The data generated and analysed during this study. (RAR 1282 kb)
DOI: 10.6084/m9.figshare.7641662.v1
title: Additional file 2: of Aerobic prokaryotes do not have higher GC contents than anaerobic prokaryotes, but obligate aerobic prokaryotes have

description: The data generated and analysed during this study. (RAR 1282 kb)
DOI: 10.6084/m9.figshare.14457041
title: Additional file 2 of Optimized polyepitope neoantigen DNA vaccines elicit neoantigen-specific immune responses in preclinical models and in clinical translation

description: Additional file 2: This file contains Supplementary Table S1 to S4. Table S1. List of HLA-A2-restricted epitopes included in the octamers for optimizing polyepitope DNA vaccine design; Table S2. Selective neoantigens identified in E0771 mouse breast cancer; Table S3. Neoantigens identified in mouse breast cancer cell line 4T1.2; and Table S4. Neoantigens identified in cancer patient GTB16.
DOI: 10.6084/m9.figshare.14456814.v1
title: Additional file 2 of Analysis of miRNA-mediated regulation of flowering induction in Lilium × formolongi

description: Additional file 2: Table S1. Conserved miRNA families in lily. Table S2. Novel miRNA families in lily. Table S3. Significant differential expression of miRNAs in lily. Table S4. Identified and annotated target transcripts for the conservative miRNAs in lily. Table S5. Identified and annotated target transcripts for the novel miRNAs in lily. Table S6. Specific RT-qPCR primers of lily. Table S7. The nodes of the gene network weight analysis results generated by WGCNA. Table S8. The edges of the gene network weight analysis results generated by WGCNA.
DOI: 10.6084/m9.figshare.9739310
title: A Precise Algorithm for Computing Sun Position on a Satellite

description: ABSTRACT: To meet the high precision sun tracking needs of a space deployable membrane solar concentrator and other equipment, an existing algorithm for accurately computing the sun position is improved. Firstly, compared with other theories, the VSOP (variation seculaires des orbits planetaires) 87 theory is selected and adopted to obtain the sun position in the second equatorial coordinate system. Comparing the results with data of the astronomical almanac from 2015, it is found that the deviation of the apparent right ascension does not exceed 0.17 arc seconds, while that of the apparent declination does not exceed 1.2 arc seconds. Then, to eliminate the difference in the direction of the sun position with respect to the satellite caused by the size of the satellite’s orbit, a translation transform is introduced in the proposed algorithm. Finally, the proposed algorithm is applied to the orbit of the satellite designated by SJ-4 (shijian-4). Under the condition that both of the existing and improved algorithms adopt the VSOP87 theory to compute sun position in the second equatorial coordinate system, the maximum deviation of the azimuth angle on the SJ-4 is 35.19 arc seconds and the one of pitch angle is 19.93 arc seconds, when the deviation is computed by subtracting the results given by both algorithms. In summary, the proposed algorithm is more accurate than the existing one.
DOI: 10.6084/m9.figshare.9739352
title: Minimally Invasive Video-assisted Mitral Valve Replacement with a Right Chest Small Incision in Patients Aged Over 65 Years

description: Abstract Objective: To analyze and summarize the clinical safety and feasibility of minimally invasive video-assisted mitral valve replacement via a right thoracic minimal incision in patients aged over 65 years. Methods: The clinical data of 45 patients over 65 years old who had mitral valve disease were analyzed retrospectively from January 2014 to January 2017 at Union Hospital, Fujian Medical University. The patients were divided into two groups; 20 patients in group A, who underwent minimally invasive video-assisted mitral valve replacement via a right thoracic minimal incision, and 25 patients in group B, who underwent conventional mitral valve replacement. We collected and analyzed their relevant clinical data. Results: The operation was completed successfully in both groups. Compared with group B, group A was clearly superior for postoperative analgesia time, postoperative hospital length of stay, thoracic drainage liquid, blood transfusion, and length of incision. There were no differences between the two groups in postoperative severe complications and mortality. More patients in group B had pulmonary infections and poor incision healing, while more patients in group A had postoperative pneumothorax and subcutaneous emphysema. Conclusion: In patients aged over 65 years, minimally invasive video-assisted mitral valve replacement with a small incision in the right chest had the same clinical safety and efficacy as the conventional method.
DOI: 10.6084/m9.figshare.9739352.v1
title: Minimally Invasive Video-assisted Mitral Valve Replacement with a Right Chest Small Incision in Patients Aged Over 65 Years

description: Abstract Objective: To analyze and summarize the clinical safety and feasibility of minimally invasive video-assisted mitral valve replacement via a right thoracic minimal incision in patients aged over 65 years. Methods: The clinical data of 45 patients over 65 years old who had mitral valve disease were analyzed retrospectively from January 2014 to January 2017 at Union Hospital, Fujian Medical University. The patients were divided into two groups; 20 patients in group A, who underwent minimally invasive video-assisted mitral valve replacement via a right thoracic minimal incision, and 25 patients in group B, who underwent conventional mitral valve replacement. We collected and analyzed their relevant clinical data. Results: The operation was completed successfully in both groups. Compared with group B, group A was clearly superior for postoperative analgesia time, postoperative hospital length of stay, thoracic drainage liquid, blood transfusion, and length of incision. There were no differences between the two groups in postoperative severe complications and mortality. More patients in group B had pulmonary infections and poor incision healing, while more patients in group A had postoperative pneumothorax and subcutaneous emphysema. Conclusion: In patients aged over 65 years, minimally invasive video-assisted mitral valve replacement with a small incision in the right chest had the same clinical safety and efficacy as the conventional method.
DOI: 10.6084/m9.figshare.9739376
title: Annuloaortic Ectasia and Arteritis: Clinical Features, Treatments of Choice, and Causative Relations

description: Abstract The roles that aortitis plays in the development of annuloaortic ectasia (AAE) remain uncertain, while clinical features of AAE in arteritis are largely unknown. This study was designed to highlight the clinical features of AAE, the treatments of choice, and the causative relations between aortitis and AAE. The morphology of the aortic valve leaflets was normal in half of the patients, while the valves were thin and overstretched in the other half. Most patients had an aortic aneurysm. Half of the patients had severe aortic valve insufficiency, and one-quarter of them had dilation of the sinuses of Valsalva. Takayasu arteritis was prone to develop coronary artery lesions, whereas giant cell arteritis were not. Aortic branch lesions in Takayasu arteritis were stenotic or occlusive in 92.9% of the patients, while in giant cell arteritis, they were all dilated lesions. Most patients (94.7%) required surgical treatment with steroid therapy. However, long-term follow-up results showed a higher anastomotic dehiscence rate, particularly in patients with Takayasu arteritis. Further morphometric and pathological research on AAE in arteritis should be undertaken, and more feasible measures should be warranted for preventing postoperative anastomotic dehiscence.
DOI: 10.6084/m9.figshare.9739376.v1
title: Annuloaortic Ectasia and Arteritis: Clinical Features, Treatments of Choice, and Causative Relations

description: Abstract The roles that aortitis plays in the development of annuloaortic ectasia (AAE) remain uncertain, while clinical features of AAE in arteritis are largely unknown. This study was designed to highlight the clinical features of AAE, the treatments of choice, and the causative relations between aortitis and AAE. The morphology of the aortic valve leaflets was normal in half of the patients, while the valves were thin and overstretched in the other half. Most patients had an aortic aneurysm. Half of the patients had severe aortic valve insufficiency, and one-quarter of them had dilation of the sinuses of Valsalva. Takayasu arteritis was prone to develop coronary artery lesions, whereas giant cell arteritis were not. Aortic branch lesions in Takayasu arteritis were stenotic or occlusive in 92.9% of the patients, while in giant cell arteritis, they were all dilated lesions. Most patients (94.7%) required surgical treatment with steroid therapy. However, long-term follow-up results showed a higher anastomotic dehiscence rate, particularly in patients with Takayasu arteritis. Further morphometric and pathological research on AAE in arteritis should be undertaken, and more feasible measures should be warranted for preventing postoperative anastomotic dehiscence.
DOI: 10.6084/m9.figshare.7642226
title: Enhanced chemotherapeutic efficacy of the low-dose doxorubicin in breast cancer via nanoparticle delivery system crosslinked hyaluronic acid

description: Despite the development of treatment options in breast cancer, many patients die of recurrence and metastasis. Owing to enhanced permeability and retention in solid tumor tissue, nanoparticle (NP) delivery systems have been emerged as novel strategy in cancer chemotherapy. As extracellular matrix, glycosaminoglycan hyaluronan (HA) could bind its surface receptor adhesion molecule CD44 which is strongly expressed on breast cancer. We have previously reported a doxorubicin (DOX)-loaded HA-Lys-LA X-NPs (X-NP-DOX) NP delivery system for breast cancer treatment. In this study, we further investigated the antitumor effect of X-NP-DOX NP delivery system using low-dose DOX in both <i>in vitro</i> and <i>in vivo</i> systems. We demonstrated that low-dose X-NP-DOX possessed the ability for inhibiting MCF-7 breast cancer cell growth, invasion, and migration, and inducing apoptosis <i>in vitro</i>. In <i>in vivo</i> experiments, injection of low-dose X-NP-DOX into tumor-bearing mouse resulted in significant reduction of tumor size. Terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling staining further revealed that low-dose X-NP-DOX induced higher percentage of apoptotic cells compared with free DOX or saline. Furthermore, our study demonstrated that low-dose X-NP-DOX inhibited Notch1 and Ras/MAPK pathways, decreased cancer stem cell population, and reduced tumorigenesis compared to free DOX in both <i>in vitro</i> and <i>in vivo</i> settings. Owing to its enhanced efficacy and higher targetability compared to free DOX, low-dose DOX delivered by NP system may be a promising novel strategy for breast cancer treatment.
DOI: 10.6084/m9.figshare.7642226.v1
title: Enhanced chemotherapeutic efficacy of the low-dose doxorubicin in breast cancer via nanoparticle delivery system crosslinked hyaluronic acid

description: Despite the development of treatment options in breast cancer, many patients die of recurrence and metastasis. Owing to enhanced permeability and retention in solid tumor tissue, nanoparticle (NP) delivery systems have been emerged as novel strategy in cancer chemotherapy. As extracellular matrix, glycosaminoglycan hyaluronan (HA) could bind its surface receptor adhesion molecule CD44 which is strongly expressed on breast cancer. We have previously reported a doxorubicin (DOX)-loaded HA-Lys-LA X-NPs (X-NP-DOX) NP delivery system for breast cancer treatment. In this study, we further investigated the antitumor effect of X-NP-DOX NP delivery system using low-dose DOX in both <i>in vitro</i> and <i>in vivo</i> systems. We demonstrated that low-dose X-NP-DOX possessed the ability for inhibiting MCF-7 breast cancer cell growth, invasion, and migration, and inducing apoptosis <i>in vitro</i>. In <i>in vivo</i> experiments, injection of low-dose X-NP-DOX into tumor-bearing mouse resulted in significant reduction of tumor size. Terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling staining further revealed that low-dose X-NP-DOX induced higher percentage of apoptotic cells compared with free DOX or saline. Furthermore, our study demonstrated that low-dose X-NP-DOX inhibited Notch1 and Ras/MAPK pathways, decreased cancer stem cell population, and reduced tumorigenesis compared to free DOX in both <i>in vitro</i> and <i>in vivo</i> settings. Owing to its enhanced efficacy and higher targetability compared to free DOX, low-dose DOX delivered by NP system may be a promising novel strategy for breast cancer treatment.
DOI: 10.6084/m9.figshare.14457300
title: Additional file 2 of Small RNA sequencing reveals distinct nuclear microRNAs in pig granulosa cells during ovarian follicle growth

description: Additional file 2.
DOI: 10.6084/m9.figshare.14457300.v1
title: Additional file 2 of Small RNA sequencing reveals distinct nuclear microRNAs in pig granulosa cells during ovarian follicle growth

description: Additional file 2.
DOI: 10.6084/m9.figshare.9739496
title: Early Outcomes of Low Postoperative Bleeding after Off-Pump Coronary Artery Bypass Grafting

description: Abstract Objective: To investigate whether low bleeding influences the early outcomes after off-pump coronary artery bypass grafting (CABG). Methods: Retrospective analysis of ischemic heart disease patients who underwent off-pump CABG from January 2013 to December 2017. Patients were divided into low-bleeding group (n=659) and bleeding group (n=270), according to total drainage from chest tube during the first postoperative 12 hours. Clinical material and early outcomes were compared between the groups. Results: Baseline was similar in the two groups. Operation time was 270±51 min in the low-bleeding group and 235±46 min in the bleeding group (P&lt;0.0001). The low-bleeding group presented smaller drainage during the first 12 h (237±47 ml) and shorter mechanical ventilation time (6.86±3.78 h) than the bleeding group (557±169 ml and 10.66±5.19 h, respectively) (P&lt;0.0001). Hemodynamic status was more stable in the low-bleeding group (P&lt;0.0001) and usage rate of more than two vasoactive agents in this group was lower than in the bleeding group (P&lt;0.0001). Number of distal anastomosis, reoperation for bleeding, suddenly increase in chest tube output, intensive care unit (ICU) stay, hospital stay, and other early outcomes had no statistical significance between the groups (P&gt;0.05). Conclusion: Postoperative bleeding &lt; 300 ml/12 h in off-pump CABG patients did not require blood product transfusion and reoperation and that would contribute to reduction in mechanical ventilation time and maintaining hemodynamic stability. Bleeding &lt; 800 ml during the first postoperative 12 h did not increase infection rates and ICU length of stay.