cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.13020588
title: Clinical efficacy of external beam radiotherapy complementing incomplete transarterial chemoembolization for hepatocellular carcinoma

description: External beam radiotherapy (EBRT) has been commonly applied as salvage or a combination locoregional modality after transarterial chemoembolization (TACE) for hepatocellular carcinomas (HCCs). This study reports oncologic outcomes and feasibility after application of the two modalities in our center. Forty consecutive patients who underwent EBRT due to incomplete responses of TACE were evaluated. Fourteen patients (35.0%) received stereotactic body radiotherapy (SBRT) and the remaining patients received conventionally fractionated radiotherapy (RT). A majority of patients who underwent SBRT received doses of 27 to 48 Gy in 3–4 fractions [median EQD<sub>2</sub> (Equivalent dose in 2 Gy per fraction radiotherapy): 57.0 Gy]. Conventionally fractionated RT was performed with a median EQD<sub>2</sub> of 47.8 Gy. The median follow-up duration was 14.4 months (range: 2.6–83.0 months). A majority (77.5%) of patients were regarded as having Child-Pugh grade A. The median tumor size was 3.4 cm (range: 0.8–20.1 cm). Ten patients (25.0%) had thrombosis at a main portal branch. The 1- and 2-year overall survival (OS) and progression-free survival (PFS) rates were 82.2% and 42.1% and 55.8% and 32.1%, respectively. The local control rates were 89.1% and 89.1% at 1 and 2 years, respectively. The albumin level was a significant factor affecting OS (<i>p</i> = .002), and the BCLC stage significantly affected PFS (<i>p</i> = .001). Intrahepatic, out-of-field recurrence was the main cause of disease progression (60.0%), and distant metastasis developed in 12 patients (30.0%) during follow-up. Non-classic radiation-induced liver disease was seen in five (12.5%) patients, and two (5%) patients experienced grade ≥3 hepatic toxicities. EBRT after incomplete TACE was feasible and yielded favorable oncologic outcomes. However, disease progression related to intrahepatic failure remained a hindrance.
DOI: 10.6084/m9.figshare.13020588.v2
title: Clinical efficacy of external beam radiotherapy complementing incomplete transarterial chemoembolization for hepatocellular carcinoma

description: External beam radiotherapy (EBRT) has been commonly applied as salvage or a combination locoregional modality after transarterial chemoembolization (TACE) for hepatocellular carcinomas (HCCs). This study reports oncologic outcomes and feasibility after application of the two modalities in our center. Forty consecutive patients who underwent EBRT due to incomplete responses of TACE were evaluated. Fourteen patients (35.0%) received stereotactic body radiotherapy (SBRT) and the remaining patients received conventionally fractionated radiotherapy (RT). A majority of patients who underwent SBRT received doses of 27 to 48 Gy in 3–4 fractions [median EQD<sub>2</sub> (Equivalent dose in 2 Gy per fraction radiotherapy): 57.0 Gy]. Conventionally fractionated RT was performed with a median EQD<sub>2</sub> of 47.8 Gy. The median follow-up duration was 14.4 months (range: 2.6–83.0 months). A majority (77.5%) of patients were regarded as having Child-Pugh grade A. The median tumor size was 3.4 cm (range: 0.8–20.1 cm). Ten patients (25.0%) had thrombosis at a main portal branch. The 1- and 2-year overall survival (OS) and progression-free survival (PFS) rates were 82.2% and 42.1% and 55.8% and 32.1%, respectively. The local control rates were 89.1% and 89.1% at 1 and 2 years, respectively. The albumin level was a significant factor affecting OS (<i>p</i> = .002), and the BCLC stage significantly affected PFS (<i>p</i> = .001). Intrahepatic, out-of-field recurrence was the main cause of disease progression (60.0%), and distant metastasis developed in 12 patients (30.0%) during follow-up. Non-classic radiation-induced liver disease was seen in five (12.5%) patients, and two (5%) patients experienced grade ≥3 hepatic toxicities. EBRT after incomplete TACE was feasible and yielded favorable oncologic outcomes. However, disease progression related to intrahepatic failure remained a hindrance.
DOI: 10.6084/m9.figshare.13469668.v2
title: Chronic exposure to low doses of ionizing radiation impacts the processing of glycoprotein N-linked glycans in Medaka (<i>Oryzias latipes</i>)

description: Ionizing radiation is found naturally in the environment. Low doses of IR may have beneficial applications, yet there is also potential for detrimental long-term health effects. Impacts following exposure to low levels of IR have been refractory to identification and quantification. Glycoprotein glycosylation is vital to cell–cell communication and organismal function, and sensitive to changes in an organism's macro- and cellular environment. We investigated whether accumulated low doses of IR (LoDIR) affect the N-linked glycoprotein glycans using Medaka fish (Oryzias latipes). State-of-the-art methods in radiation exposure and glycan analysis were applied to study N-glycan changes after 190 day exposure at three different rates of gamma irradiation (2.25, 21.01, and 204.3 mGy/day) in wild-type adult Medaka. Tissue N-glycans were analyzed following enzymatic release from extracted proteins. N-linked glycan profiles are dominated by complex type N-glycans modified with terminal sialic acid and core fucose. Fucosylation and sialylation of N-linked glycoprotein glycans are affected by LoDIR and a subset of N-glycans are involved in the organismal radio–response. This is the first indication that the glycome can be interrogated for biomarkers that report the impact of chronic exposure to environmental stressors, such as low-level IR.
DOI: 10.6084/m9.figshare.13469668
title: Chronic exposure to low doses of ionizing radiation impacts the processing of glycoprotein N-linked glycans in Medaka (<i>Oryzias latipes</i>)

description: Ionizing radiation is found naturally in the environment. Low doses of IR may have beneficial applications, yet there is also potential for detrimental long-term health effects. Impacts following exposure to low levels of IR have been refractory to identification and quantification. Glycoprotein glycosylation is vital to cell–cell communication and organismal function, and sensitive to changes in an organism's macro- and cellular environment. We investigated whether accumulated low doses of IR (LoDIR) affect the N-linked glycoprotein glycans using Medaka fish (Oryzias latipes). State-of-the-art methods in radiation exposure and glycan analysis were applied to study N-glycan changes after 190 day exposure at three different rates of gamma irradiation (2.25, 21.01, and 204.3 mGy/day) in wild-type adult Medaka. Tissue N-glycans were analyzed following enzymatic release from extracted proteins. N-linked glycan profiles are dominated by complex type N-glycans modified with terminal sialic acid and core fucose. Fucosylation and sialylation of N-linked glycoprotein glycans are affected by LoDIR and a subset of N-glycans are involved in the organismal radio–response. This is the first indication that the glycome can be interrogated for biomarkers that report the impact of chronic exposure to environmental stressors, such as low-level IR.
DOI: 10.6084/m9.figshare.12937777.v2
title: Estimating partial-body ionizing radiation exposure by automated cytogenetic biodosimetry

description: Inhomogeneous exposures to ionizing radiation can be detected and quantified with the dicentric chromosome assay (DCA) of metaphase cells. Complete automation of interpretation of the DCA for whole-body irradiation has significantly improved throughput without compromising accuracy, however, low levels of residual false positive dicentric chromosomes (DCs) have confounded its application for partial-body exposure determination. We describe a method of estimating and correcting for false positive DCs in digitally processed images of metaphase cells. Nearly all DCs detected in unirradiated calibration samples are introduced by digital image processing. DC frequencies of irradiated calibration samples and those exposed to unknown radiation levels are corrected subtracting this false positive fraction from each. In partial-body exposures, the fraction of cells exposed, and radiation dose can be quantified after applying this modification of the contaminated Poisson method. Dose estimates of three partially irradiated samples diverged 0.2–2.5 Gy from physical doses and irradiated cell fractions deviated by 2.3%–15.8% from the known levels. Synthetic partial-body samples comprised of unirradiated and 3 Gy samples from 4 laboratories were correctly discriminated as inhomogeneous by multiple criteria. Root mean squared errors of these dose estimates ranged from 0.52 to 1.14 Gy<sup>2</sup> and from 8.1 to 33.3%<sup>2</sup> for the fraction of cells irradiated. Automated DCA can differentiate whole- from partial-body radiation exposures and provides timely quantification of estimated whole-body equivalent dose.
DOI: 10.6084/m9.figshare.12937777
title: Estimating partial-body ionizing radiation exposure by automated cytogenetic biodosimetry

description: Inhomogeneous exposures to ionizing radiation can be detected and quantified with the dicentric chromosome assay (DCA) of metaphase cells. Complete automation of interpretation of the DCA for whole-body irradiation has significantly improved throughput without compromising accuracy, however, low levels of residual false positive dicentric chromosomes (DCs) have confounded its application for partial-body exposure determination. We describe a method of estimating and correcting for false positive DCs in digitally processed images of metaphase cells. Nearly all DCs detected in unirradiated calibration samples are introduced by digital image processing. DC frequencies of irradiated calibration samples and those exposed to unknown radiation levels are corrected subtracting this false positive fraction from each. In partial-body exposures, the fraction of cells exposed, and radiation dose can be quantified after applying this modification of the contaminated Poisson method. Dose estimates of three partially irradiated samples diverged 0.2–2.5 Gy from physical doses and irradiated cell fractions deviated by 2.3%–15.8% from the known levels. Synthetic partial-body samples comprised of unirradiated and 3 Gy samples from 4 laboratories were correctly discriminated as inhomogeneous by multiple criteria. Root mean squared errors of these dose estimates ranged from 0.52 to 1.14 Gy<sup>2</sup> and from 8.1 to 33.3%<sup>2</sup> for the fraction of cells irradiated. Automated DCA can differentiate whole- from partial-body radiation exposures and provides timely quantification of estimated whole-body equivalent dose.
DOI: 10.6084/m9.figshare.12937777.v1
title: Estimating partial body ionizing radiation exposure by automated cytogenetic biodosimetry

description: <b>Purpose:</b> Inhomogeneous exposures to ionizing radiation can be detected and quantified with the Dicentric Chromosome Assay (DCA) of metaphase cells. Complete automation of interpretation of the DCA for whole body irradiation has significantly improved throughput without compromising accuracy, however low levels of residual false positive dicentric chromosomes (DCs) have confounded its application for partial body exposure determination. <b>Materials and Methods</b>: We describe a method of estimating and correcting for false positive DCs in digitally processed images of metaphase cells. Nearly all DCs detected in unirradiated calibration samples are introduced by digital image processing. DC frequencies of irradiated calibration samples and those exposed to unknown radiation levels are corrected subtracting this false positive fraction from each. In partial body exposures, the fraction of cells exposed, and radiation dose can be quantified after applying this modification of the contaminated Poisson method. <b>Results:</b> Dose estimates of three partially irradiated samples diverged 0.2 to 2.5 Gy from physical doses and irradiated cell fractions deviated by 2.3-15.8% from the known levels. Synthetic partial body samples comprised of unirradiated and 3 Gy samples from 4 laboratories were correctly discriminated as inhomogeneous by multiple criteria. Root mean squared errors of these dose estimates ranged from 0.52 to 1.14 Gy<sup>2</sup> and from 8.1 to 33.3%<sup>2</sup> for the fraction of cells irradiated. <b>Conclusions</b>: Automated DCA can differentiate whole- from partial-body radiation exposures and provides timely quantification of estimated whole-body equivalent dose.
DOI: 10.6084/m9.figshare.12845228
title: Comparison of inexperienced operators and experts in γH2A.X and 53BP1 foci assay for high-throughput biodosimetry approaches in a mass casualty incident

description: In case of population exposure by ionizing radiation, a fast and reliable dose assessment of exposed and non-exposed individuals is crucial important. In initial triage, physicians have to take fast decisions whom to treat with adequate medical care. In addition, worries about significant exposure can be taken away from hundreds to thousands non- or low exposed individuals. Studies have shown that the γH2A.X radiation-induced foci assay is a promising test for fast triage decisions. However, in a large-scale scenario most biodosimetry laboratories will quickly reach their capacity limit. The aim of this study was to evaluate the benefit of inexperienced experimenters to speed up the foci assay and manual foci scoring. The participants of two training courses performed the radiation-induced foci assay (γH2A.X) under the guidance of experts and scored foci (γH2A.X and 53BP1) on sham-irradiated and irradiated blood samples (0.05–1.5 Gy). The outcome of laboratory experiments and manual foci scoring by 26 operators with basic experience in laboratory work was statistically analyzed in comparison to the results from experts. Inexperienced operators prepared slides with significant dose-effects (0, 0.1 and 1.0 Gy) for semi-automatic microscopic analyses. Manual foci scoring by inexperienced scorer resulted in a dose–effect curve for γH2A.X, 53BP1 and co-localized foci. In addition, inexperienced scorers were able to distinguish low irradiation doses from unirradiated cells. While 53BP1 foci scoring was in accordance to the expert counting, differences between beginners and expert increased for γH2A.X or co-localized foci. In case of a large-scale radiation event, inexperienced staff is useful to support laboratories in slide preparation for semi-automatic foci counting as well as γH2A.X and 53BP1 manual foci scoring for triage-mode biodosimetry. Slides can be clearly classified in the non-, low- or high-exposed category.
DOI: 10.6084/m9.figshare.12845228.v1
title: Comparison of inexperienced operators and experts in γH2A.X and 53BP1 foci assay for high-throughput biodosimetry approaches in a mass casualty incident

description: In case of population exposure by ionizing radiation, a fast and reliable dose assessment of exposed and non-exposed individuals is crucial important. In initial triage, physicians have to take fast decisions whom to treat with adequate medical care. In addition, worries about significant exposure can be taken away from hundreds to thousands non- or low exposed individuals. Studies have shown that the γH2A.X radiation-induced foci assay is a promising test for fast triage decisions. However, in a large-scale scenario most biodosimetry laboratories will quickly reach their capacity limit. The aim of this study was to evaluate the benefit of inexperienced experimenters to speed up the foci assay and manual foci scoring. The participants of two training courses performed the radiation-induced foci assay (γH2A.X) under the guidance of experts and scored foci (γH2A.X and 53BP1) on sham-irradiated and irradiated blood samples (0.05–1.5 Gy). The outcome of laboratory experiments and manual foci scoring by 26 operators with basic experience in laboratory work was statistically analyzed in comparison to the results from experts. Inexperienced operators prepared slides with significant dose-effects (0, 0.1 and 1.0 Gy) for semi-automatic microscopic analyses. Manual foci scoring by inexperienced scorer resulted in a dose–effect curve for γH2A.X, 53BP1 and co-localized foci. In addition, inexperienced scorers were able to distinguish low irradiation doses from unirradiated cells. While 53BP1 foci scoring was in accordance to the expert counting, differences between beginners and expert increased for γH2A.X or co-localized foci. In case of a large-scale radiation event, inexperienced staff is useful to support laboratories in slide preparation for semi-automatic foci counting as well as γH2A.X and 53BP1 manual foci scoring for triage-mode biodosimetry. Slides can be clearly classified in the non-, low- or high-exposed category.
DOI: 10.6084/m9.figshare.14560812
title: The HINDMARSH-ROSE SYSTEM

description: 1- We obtain 10^6 data from Hindmarsh-Rose choatic dynamical system by the four-step Runge-Kutta method, see MATT1-MATT2-MATT3-MATT4.-------------------------------------------------2- We get 256 values from MATT2.txt. See a1 and a2.---------------------------------------------------3- We sort the a1.txt and a2.txt files incrementally. Outputs are called b1 and b2.-----------------------------------------------------4- We obtain S-boxes 1,2,3 and 4 by algorithms 1.---------------------------------------------------5- The Sbox5.txt is obtained by zigzag transform in algorithm 2.
DOI: 10.6084/m9.figshare.14560812.v1
title: The HINDMARSH-ROSE SYSTEM

description: 1- We obtain 10^6 data from Hindmarsh-Rose choatic dynamical system by the four-step Runge-Kutta method, see MATT1-MATT2-MATT3-MATT4.-------------------------------------------------2- We get 256 values from MATT2.txt. See a1 and a2.---------------------------------------------------3- We sort the a1.txt and a2.txt files incrementally. Outputs are called b1 and b2.-----------------------------------------------------4- We obtain S-boxes 1,2,3 and 4 by algorithms 1.---------------------------------------------------5- The Sbox5.txt is obtained by zigzag transform in algorithm 2.
DOI: 10.6084/m9.figshare.14560839
title: Hindmarsh-Rose system

description: 1- We obtain 10^6 data from Hindmarsh-Rose choatic dynamical system by the four-step Runge-Kutta method, see MATT1-MATT2-MATT3-MATT4.-------------------------------------------------2- We get 256 values from MATT2.txt. See a1 and a2.---------------------------------------------------3- We sort the a1.txt and a2.txt files incrementally. Outputs are called b1 and b2.-----------------------------------------------------4- We obtain S-boxes 1,2,3 and 4 by algorithms 1.---------------------------------------------------5- The Sbox5.txt is obtained by zigzag transform in algorithm 2.
DOI: 10.6084/m9.figshare.14560839.v1
title: Hindmarsh-Rose system

description: 1- We obtain 10^6 data from Hindmarsh-Rose choatic dynamical system by the four-step Runge-Kutta method, see MATT1-MATT2-MATT3-MATT4.-------------------------------------------------2- We get 256 values from MATT2.txt. See a1 and a2.---------------------------------------------------3- We sort the a1.txt and a2.txt files incrementally. Outputs are called b1 and b2.-----------------------------------------------------4- We obtain S-boxes 1,2,3 and 4 by algorithms 1.---------------------------------------------------5- The Sbox5.txt is obtained by zigzag transform in algorithm 2.
DOI: 10.5281/zenodo.4743420
title: SILVER - phantom data

description: pre-processed (using `read_and_save_TURBINE.m`) k-space TURBINE data in phantom acquired on 3T Siemens Prisma 15.12.2020. Angles with which data was acquired (a, and b are repeats of the same acquisition method):<br> 1 - GR (111.24610)<br> 2 - UNIFORM 1/46 (3.9130)<br> 3 - UNIFORM 1/55 (3.2727)<br> 4 - UNIFORM 1/10 (18.0000)<br> 5 - UNIFORM 1/8 (22.5000)<br> 6 - SILVER {8,55} electrostatic_potential (157.1022)<br> 7 - SILVER {8,55} winkelmann (22.9010)<br> 8 - SILVER {10,46} electrostatic_potential (53.6145)<br> 9 - SILVER {10,46} winkelmann (144.7651) Sensitivity maps derived from the GR are also included along with noise covariance.
DOI: 10.5281/zenodo.4743419
title: SILVER - phantom data

description: pre-processed (using `read_and_save_TURBINE.m`) k-space TURBINE data in phantom acquired on 3T Siemens Prisma 15.12.2020. Angles with which data was acquired (a, and b are repeats of the same acquisition method):<br> 1 - GR (111.24610)<br> 2 - UNIFORM 1/46 (3.9130)<br> 3 - UNIFORM 1/55 (3.2727)<br> 4 - UNIFORM 1/10 (18.0000)<br> 5 - UNIFORM 1/8 (22.5000)<br> 6 - SILVER {8,55} electrostatic_potential (157.1022)<br> 7 - SILVER {8,55} winkelmann (22.9010)<br> 8 - SILVER {10,46} electrostatic_potential (53.6145)<br> 9 - SILVER {10,46} winkelmann (144.7651) Sensitivity maps derived from the GR are also included along with noise covariance.
DOI: 10.3886/e119446v90
title: COVID-19 US State Policy Database

description: For questions or comments about the database please contact:<br>Alexandra Skinner <br>skinnera@bu.edu <br>Research Fellow & Database Manager<br>Department of Health Law, Policy & Management <br>Boston University School of Public Health<br><br>Database of state policies on closures, shelter-in-place orders, housing protections, changes to Medicaid and SNAP, physical distancing closures, reopening, and more created by researchers at the Boston University School of Public Health. Policies included are state-wide directives or mandates, not guidance or recommendations. In order for a policy to be included, it must apply to the entire state. We are working quickly to go through state government websites to make the policy database as complete and accurate as possible in a rapidly changing policy context. If you use data on a given policy, we encourage you to triangulate based on additional sources of policy data and to review the source documentation to consider the coding decisions that are right for your work. Of course, please email us if you note a discrepancy so we can improve the database for everyone. State policy source documentation can be found at: tinyurl.com/statepolicysources.
description: State policies. Smallest Geographic Unit: State
description: other; Contributors: Megan Cole Brahim, Noa Krawczyk, Carolyn Hoffman, Claire Corkish, Elizabeth Ferrara, Elizabeth Long, Emily Baroni, Faith Contador, Hannah Simon, Morgan Simko, Rachel Scheckman, Sarah Brewer, Sue Kulkarni, Felicia Heykoop, Manish Patel, Aishwarya Vidyasagaran, Andrew Chiao, Cara Safon, Samantha Burkhart, Harry Jung, Victor Lee, Marina MacKinnon, Aarohi Rede, Marie Vearling, Sophie Li, Christina Wang, Tim Levengood, María Jordán P. Emma Chistolini
DOI: 10.5281/zenodo.4743896
title: ALBA Experiment May 2021

description: ALBA Experiment May 2021
DOI: 10.5281/zenodo.4743895
title: ALBA Experiment May 2021

description: ALBA Experiment May 2021