cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.5539864
title: Supplementary Material for: Early Cognitive Impairment after Intracerebral Hemorrhage in the INTERACT1 Study

description: <b><i>Background:</i></b> Data on cognitive impairment after acute intracerebral hemorrhage (ICH) are limited. This study is aimed at determining the frequency and predictors of cognitive impairment among participants of the pilot phase, Intensive Blood Pressure (BP) Reduction in Acute Cerebral Hemorrhage Trial (INTERACT1). <b><i>Methods:</i></b> INTERACT1 was an open randomized trial of early intensive (target systolic BP &lt;140 mm Hg) compared with contemporaneous guideline-recommended BP lowering in 404 patients with elevated systolic BP (150–220 mm Hg) within 6 h of ICH onset. Cognitive impairment was defined by scores ≤24 on the Mini-Mental State Examination (MMSE) assessed by interview on follow-up at 90 days. <b><i>Results:</i></b> A total of 231 (64.5%) of 358 90-day survivors had MMSE scores for analyses, and 75 (32.5%) had cognitive impairment. In multivariable analysis, older age (OR 2.48, 95% CI 1.73–3.56 per 10-year increase; <i>p</i> &lt; 0.001), female sex (OR 2.06, 95% CI 1.00–4.23; <i>p</i> = 0.049), prior ICH (OR 2.87, 95% CI 1.08–7.65; <i>p</i> = 0.035), high baseline National Institute of Health Stroke Scale score (OR 1.06, 95% CI 1.00–1.13; <i>p</i> = 0.044), and high mean systolic BP over the first 24 h post-randomization (OR 1.34, 95% CI 1.07–1.68/10 mm Hg increase; <i>p</i> = 0.011) were independently associated with cognitive impairment. <b><i>Conclusions:</i></b> One third of patients have significant cognitive impairment early after ICH, which is more frequent in the elderly, females, those with prior ICH, and more severe initial neurological deficit and with persistently high early systolic BP.
DOI: 10.6084/m9.figshare.5539873.v1
title: Computed tomography in hypersensitivity pneumonitis: main findings, differential diagnosis and pitfalls

description: <b>Introduction</b>: Hypersensitivity pneumonitis (HP) is a disease with variable clinical presentation in which inflammation in the lung parenchyma is caused by the inhalation of specific organic antigens or low molecular weight substances in genetically susceptible individuals. Alterations of the acute, subacute and chronic forms may eventually overlap, and the diagnosis based on temporality and presence of fibrosis (acute/inflammatory HP <i>vs</i>. chronic HP) seems to be more feasible and useful in clinical practice. Differential diagnosis of chronic HP with other interstitial fibrotic diseases is challenging due to the overlap of the clinical history, and the functional and imaging findings of these pathologies in the terminal stages. <b>Areas covered</b>: This article reviews the essential features of HP with emphasis on imaging features. Moreover, the main methodological limitations of high-resolution computed tomography (HRCT) interpretation are discussed, as well as new perspectives with volumetric quantitative CT analysis as a useful tool for retrieving detailed and accurate information from the lung parenchyma. <b>Expert commentary</b>: Mosaic attenuation is a prominent feature of this disease, but air trapping in chronic HP seems overestimated. Quantitative analysis has the potential to estimate the involvement of the pulmonary parenchyma more accurately and could correlate better with pulmonary function results.
DOI: 10.6084/m9.figshare.5539882.v1
title: Supplementary Material for: Temporal Associations between Fatigue, Depression, and Apathy after Stroke: Results of the Cognition and Affect after Stroke, a Prospective Evaluation of Risks Study

description: <b><i>Background:</i></b> Poststroke fatigue (PSF) is a form of pathological fatigue that can develop after stroke and has a negative impact on functional outcome. PSF is associated with poststroke depression (PSD), which in turn shows similarities with poststroke apathy (PSA). This study aimed at disentangling the temporal associations between PSF and PSD and between PSF and PSA. <b><i>Methods:</i></b> A total of 250 stroke patients were included, of which 243 completed the Fatigue Severity Scale, Montgomery-Åsberg Depression Rating Scale, and Apathy Evaluation Scale at 3 months poststroke, with follow-up measurements at 6 and 12 months after initial testing. Linear mixed models and linear regressions were performed to evaluate the temporal associations between PSF and PSD, and between PSF and PSA. <b><i>Results:</i></b> PSF was present in 119 patients (49%), of whom 62 patients also had PSD (26%), and 21 patients (9%) also had PSA. At baseline, PSF patients showed higher depression levels, which remained stable at follow-up. PSD patients had higher fatigue levels compared with no-PSD patients at baseline, which remained stable at follow-up. No association between apathy and fatigue was found at baseline and no interaction with time was found. Change in fatigue from baseline to 12-month follow-up was associated with change in depression and with change in apathy. <b><i>Conclusions:</i></b> Bidirectional associations were found between PSF and PSD. In treatment and rehabilitation programs, early focus on the presence of PSD and PSF is important, since these conditions tend to persist. As there are currently more treatment options for PSD, attention for PSD is important and might also have a beneficial effect on PSF.
DOI: 10.6084/m9.figshare.5539855
title: Supplementary Material for: Isolated Cleft Lip and Palate: Maxillary Gap Sign and Palatino-Maxillary Diameter at 11–13 Weeks

description: <b><i>Objective:</i></b> To evaluate the maxillary gap sign and describe markers for the first-trimester diagnosis of isolated cleft lip and palate (CLP) at 11–13 weeks. <b><i>Methods:</i></b> Firstly, this was a prospective assessment of 1,087 fetuses including 5 cases of isolated CLP in 2 centers which were referred for the 11–13 weeks scan. Secondly, intra- and interobserver variability of the maxillary gap sign was evaluated for observers R.L. and A.B. in 2 sessions (affected cases vs. 50 normal fetuses in each session) to reduce the bias of different ultrasound manufacturer visualizations (Philips, GE). Thirdly, the palatino-maxillary diameter (PMD) was examined in stored images, DICOM loops and volumes of the midsagittal and parasagittal view of the fetal head and brain at 11<sup>+0</sup>–13<sup>+6</sup> weeks of gestation from 5 fetuses with isolated CLP and 302 consecutively assessed normal controls. The PMD values in fetuses with isolated CLP and normal controls were compared. <b><i>Results:</i></b> Firstly, 5 out of 6 referred pregnancies with isolated CLP were detected prospectively using the midsagittal view for measurement of nuchal translucency due to an abnormal appearance. One out of 6 patients with isolated CLP declined the 11–13 weeks scan. Secondly, intra- and interobserver variability showed no false positive cases; all cases with isolated CLP were identified by both sonographers; however, in 2 cases the maxillary gap sign was doubtful. Therefore, thirdly, we developed the PMD measurement which increased significantly with crown-rump length (CRL) from respective mean values at CRL of 45 mm to 4.66 mm and to 8.95 mm at CRL of 84 mm. In the CLP group, the PMD was below the 5th percentile of the control group in 4 out of 5 (80%) cases. <b><i>Conclusions:</i></b> The midsagittal view for measurement of nuchal translucency shows a high reproducibility regarding abnormal views for maxillary gap sign. In the midsagittal view of the fetal head, face, and brain at 11–13 weeks, the majority of fetuses with isolated CLP have a measurable abnormality in addition, the PMD.
DOI: 10.6084/m9.figshare.5539852
title: The climatology of mixed layer depth in the Red Sea

description: The climatology of mixed layer depth variability in the Red Sea is attached. <br>
DOI: 10.6084/m9.figshare.5539864.v1
title: Supplementary Material for: Early Cognitive Impairment after Intracerebral Hemorrhage in the INTERACT1 Study

description: <b><i>Background:</i></b> Data on cognitive impairment after acute intracerebral hemorrhage (ICH) are limited. This study is aimed at determining the frequency and predictors of cognitive impairment among participants of the pilot phase, Intensive Blood Pressure (BP) Reduction in Acute Cerebral Hemorrhage Trial (INTERACT1). <b><i>Methods:</i></b> INTERACT1 was an open randomized trial of early intensive (target systolic BP &lt;140 mm Hg) compared with contemporaneous guideline-recommended BP lowering in 404 patients with elevated systolic BP (150–220 mm Hg) within 6 h of ICH onset. Cognitive impairment was defined by scores ≤24 on the Mini-Mental State Examination (MMSE) assessed by interview on follow-up at 90 days. <b><i>Results:</i></b> A total of 231 (64.5%) of 358 90-day survivors had MMSE scores for analyses, and 75 (32.5%) had cognitive impairment. In multivariable analysis, older age (OR 2.48, 95% CI 1.73–3.56 per 10-year increase; <i>p</i> &lt; 0.001), female sex (OR 2.06, 95% CI 1.00–4.23; <i>p</i> = 0.049), prior ICH (OR 2.87, 95% CI 1.08–7.65; <i>p</i> = 0.035), high baseline National Institute of Health Stroke Scale score (OR 1.06, 95% CI 1.00–1.13; <i>p</i> = 0.044), and high mean systolic BP over the first 24 h post-randomization (OR 1.34, 95% CI 1.07–1.68/10 mm Hg increase; <i>p</i> = 0.011) were independently associated with cognitive impairment. <b><i>Conclusions:</i></b> One third of patients have significant cognitive impairment early after ICH, which is more frequent in the elderly, females, those with prior ICH, and more severe initial neurological deficit and with persistently high early systolic BP.
DOI: 10.6084/m9.figshare.5539810
title: Dataset of generated and evaluated residential buildings of two storeys with random U-values for opaque and transparent exterior elements

description: The geometric data was generated using the EPSAP algorithm; the construction elements physical properties were saved from the EPSAP algorithm database; and, the performance data was obtained using the FPOP algorithm coupled to the simulation engine EnergyPlus v8.8.0. The weather files used in the simulations were the PRT_Lisboa, PRT_Porto, ESP_Toledo, ITA_Milan, ROU_Bucharest, SWE_Kiruna, SWE_Stockholm data available at the Department of Energy (URL https://energyplus.net/weather).<br>
DOI: 10.6084/m9.figshare.5539852.v2
title: The climatology of mixed layer depth in the Red Sea

description: The climatology of mixed layer depth variability in the Red Sea is attached. <br>
DOI: 10.6084/m9.figshare.5539804
title: Comparative analysis of gene co-expression networks

description: The files constitute the necessary software and input data for conducting s-core/s-core+ network analysis on 4 gene co-expression networks (2 in homo sapiens, 2 in mus musculus).<br>The README.txt file describes how to run the perl script "s-core_plus.pl" on the network data available in the "networks.tgz" tar and gzipped file.
DOI: 10.6084/m9.figshare.5539789
title: Distribution and diversity of amphibians in Albania: new data and foundations of a comprehensive database. Supplementary Material

description: Albania is part of the Mediterranean biodiversity hotspot. Yet its amphibian fauna is poorly known due to little scientific exploration during the long political isolation of the country. To fill this gap, we constructed a georeferenced database with occurrences of all known amphibian species based on records from published sources and personal data collected during expeditions to poorly known areas. Our database includes 1097 records of 16 species collected between 1920 and 2017. Based on aggregated records, we analysed richness patterns of amphibians in 10 × 10 km grid cells as a function of altitude, climate, land cover diversity and distance from the sea. The mean number of species per cell was 1.8 ± 0.11 S.E. (maximum: 10 species) and at least one species occurred in 238 of the 349 cells. Sampling effort was uneven and sampling hotspots were mostly in popular sites of natural heritage. Cells with high amphibian diversity were near the Prokletije Mountains in the North-West, near Lura, Korab and Grammos Mountains and Ohrid and Prespa Lakes in the East, and near Çikës Mountains and in coastal areas of Vlorë in the South-West. General linear models showed that the most important predictors of presence and diversity of amphibian species are land cover diversity and precipitation. Our study presents the largest database of amphibian occurrences in Albania to date that will be useful for biogeographical and ecological studies and for conservation purposes.
DOI: 10.6084/m9.figshare.5539804.v1
title: Comparative analysis of gene co-expression networks

description: The files constitute the necessary software and input data for conducting s-core/s-core+ network analysis on 4 gene co-expression networks (2 in homo sapiens, 2 in mus musculus).<br>The README.txt file describes how to run the perl script "s-core_plus.pl" on the network data available in the "networks.tgz" tar and gzipped file.
DOI: 10.6084/m9.figshare.5539852.v1
title: The climatology of mixed layer depth in the Red Sea

description: The climatology of mixed layer depth variability in the Red Sea is attached. This climatology produced from insitu observations collected during 1934 to 2017<br>
DOI: 10.6084/m9.figshare.5539789.v1
title: Distribution and diversity of amphibians in Albania: new data and foundations of a comprehensive database. Supplementary Material

description: Albania is part of the Mediterranean biodiversity hotspot. Yet its amphibian fauna is poorly known due to little scientific exploration during the long political isolation of the country. To fill this gap, we constructed a georeferenced database with occurrences of all known amphibian species based on records from published sources and personal data collected during expeditions to poorly known areas. Our database includes 1097 records of 16 species collected between 1920 and 2017. Based on aggregated records, we analysed richness patterns of amphibians in 10 × 10 km grid cells as a function of altitude, climate, land cover diversity and distance from the sea. The mean number of species per cell was 1.8 ± 0.11 S.E. (maximum: 10 species) and at least one species occurred in 238 of the 349 cells. Sampling effort was uneven and sampling hotspots were mostly in popular sites of natural heritage. Cells with high amphibian diversity were near the Prokletije Mountains in the North-West, near Lura, Korab and Grammos Mountains and Ohrid and Prespa Lakes in the East, and near Çikës Mountains and in coastal areas of Vlorë in the South-West. General linear models showed that the most important predictors of presence and diversity of amphibian species are land cover diversity and precipitation. Our study presents the largest database of amphibian occurrences in Albania to date that will be useful for biogeographical and ecological studies and for conservation purposes.
DOI: 10.6084/m9.figshare.5539744
title: Supplementary Material for: Aberrant Expression of Long Non-Coding RNAs in Newly Diagnosed Type 2 Diabetes Indicates Potential Roles in Chronic Inflammation and Insulin Resistance

description: <b><i>Background/Aims:</i></b> Long non-coding RNAs (lncRNAs) have emerged as key players in several biological processes and complex diseases. The risk of type 2 diabetes (T2D) is determined by a combination of environmental factors and genetic susceptibility. The purpose of this study was to identify aberrant lncRNAs involved in T2D pathogenesis. <b><i>Methods:</i></b> Microarray analysis was performed using whole blood samples from patients newly diagnosed with T2D and healthy controls. Pathway and Gene Ontology (GO) analyses were utilized to annotate the target genes. Coding non-coding co-expression (CNC) analysis was performed to construct a co-expression network. <b><i>Results:</i></b> We found 55 lncRNAs and 202 mRNAs were differentially expressed in the T2D group compared to the healthy control group. Pathway and GO analyses demonstrated that dysregulated mRNAs were mainly associated with immune regulation, inflammation, and insulin resistance, whereas CNC analysis identified 10 pairs of co-expressed lncRNA-mRNAs in our patient cohort (R &gt; 0.99). Furthermore, expression of the top three upregulated lncRNAs in the T2D group was correlated with measures of glycometabolism (<i>P</i> &lt; 0.05). <b><i>Conclusion:</i></b> This study identified aberrantly expressed lncRNAs and mRNAs in Han Chinese patients with T2D, and demonstrated that dysregulated lncRNAs may have roles in T2D pathogenesis through regulation of inflammation and insulin resistance.
DOI: 10.6084/m9.figshare.5539726
title: Supplementary Material for: Allele Drop Out Conferred by a Frequent CYP2D6 Genetic Variation For Commonly Used CYP2D6*3 Genotyping Assays

description: <b><i>Background/Aim:</i></b> Accurate genotyping of <i>CYP2D6</i> is challenging due to its inherent genetic variation, copy number variation (duplications and deletions) and hybrid formation with highly homologous pseudogenes. Because a relatively high percentage (∼25%) of clinically prescribed drugs are substrates for this enzyme, accurate determination of its genotype for phenotype prediction is essential. <b><i>Methods:</i></b> A cohort of 365 patient samples was genotyped for <i>CYP2D6</i> using Sanger sequencing (as the gold standard), hydrolysis probe assays or pyrosequencing. <b><i>Results:</i></b> A discrepant result between the three genotyping methods for the loss of function <i>CYP2D6*3</i> (g.2549delA, rs35742686) genetic variant was found in one of the samples. This sample also contained the <i>CYP2D6</i> g.2470T&gt;C (rs17002852) variation, which had an allele frequency of 2.47% in our cohort. Redesign of the <i>CYP2D6*3</i> pyrosequencing and hydrolysis probe assays to avoid <i>CYP2D6</i> g.2470 corrected the anomaly. <b><i>Conclusion:</i></b> To evidence allele drop out and increase the accuracy of genotyping, intra-patient validation of the same genetic variation with at least two separate methods should be considered.
DOI: 10.6084/m9.figshare.5539648
title: <b>β</b>-nerve growth factor identification in male rabbit genital tract and seminal plasma and its role in ovulation induction in rabbit does

description: The neurotrophin β-nerve growth factor (NGF) has been described as an important mediator of seminal plasma-induced ovulation in reflexive ovulators like camelids, but this action has not been evidenced in rabbits. In this study, the mRNA expression of NGF was analysed in rabbit male organs by PCR and in a purified basic fraction of seminal plasma by liquid chromatography mass spectrometry. Besides, the ovulatory response [ovulation rate (OR), corpora lutea number, LH peak and progesterone profile] of 27 rabbit does was recorded after injection with murine NGF, gonadoreline (GnRH) or saline solution (SS). An empty catheter was introduced through the vagina (<i>n</i> = 4 animals per group) to simulate the nervous/mechanical stimulus of coitus. Molecular studies confirmed the expression of β-NGF mRNA in the prostate, seminal gland and testicles of male adult rabbits, and the presence of the protein in seminal plasma. For the <i>in vivo</i> experiment, all GnRH-group does exhibited a significantly higher OR (100%) compared to females treated with NGF (30%) and SS (25%), who showed significantly lower LH and progesterone concentrations at 120 min. However, in the non-vaginally stimulated animals, only the gonadoreline group ovulated properly, since no ovulation was recorded in the SS group, and only 17% of the NGF does ovulated; this was associated to a tendency to a higher rate of anovulatory haemorrhagic follicles. mRNA expression of NGF and its presence in seminal plasma evidence a role in rabbit reproduction. Nevertheless, murine NGF triggered some stimulatory effect in the females but not enough to elicit a significant ovulatory response.
DOI: 10.5281/zenodo.4010238
title: Theater questionnair data and BP neural network prediction network

description: More than 1500 questionnaires were distributed to the three theaters, and a total of 1382 valid questionnaires were collected for this study: 416 in small-scale theater, 478 in medium-scale theater, 488 in large-scale theater.
DOI: 10.6084/m9.figshare.5539630
title: Fowl adenovirus-induced diseases and strategies for their control – a review on the current global situation

description: The stand-alone pathogenicity of fowl adenoviruses (FAdVs) had long been disputed, given the ubiquity of the viruses versus sporadic outbreaks, and variation between experimental studies. However, a globally emerging trend of FAdV-associated diseases has marked the past two decades, with hepatitis-hydropericardium syndrome mainly in Asia besides Arabian and Latin American countries, and geographically more disseminated outbreaks of inclusion body hepatitis. Finally, the appearance of FAdV-induced gizzard erosion (AGE) in Asia and Europe completed the range of diseases. Epidemiological studies confirmed serotype FAdV-4 as agent of hepatitis-hydropericardium syndrome, whereas inclusion body hepatitis is related to FAdV-2, -8a, -8b and -11. Members of the biologically more distant serotype FAdV-1 induce AGE. Urged by increasing problems in the field, numerous pathogenicity studies with FAdVs from outbreaks substantiated the primary aetiologic role of particular strains for distinct clinical conditions. Developments in the poultry industry towards highly specialized genetic breeds and rigorous biosecurity additionally contribute to the growing incidence of FAdV-related diseases. Confirming field observations, recent studies connected a higher susceptibility of broilers with their distinct physiology, implying the choice of bird type as a factor to be considered in infection studies. Furthermore, elevated biosecurity standards have generated immunologically naïve breeding stocks, putting broilers at risk in face of vertical FAdV transmission. Therefore, future prevention strategies should include adequate antibodies in breeders prior to production and – if necessary – vaccination, in order to protect progenies. This review aims to deliver a detailed overview on the current global situation about FAdV-induced diseases, their reproduction <i>in vivo</i> and vaccination strategies.