cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.5523/bris.1ckssqmdmilj023w7f0gr36o06
title: Mid-infrared quantum optics in silicon supporting data

description: Applied quantum optics stands to revolutionise many aspects of information technology, provided performance can be maintained when scaled up. Silicon quantum photonics satisfies the scaling requirements of miniaturisation and manufacturability, but at 1.55 μm it suffers from problematic linear and nonlinear loss. Here we show that, by translating silicon quantum photonics to the mid-infrared, a new quantum optics platform is created which can simultaneously maximise manufacturability and miniaturisation, while reducing loss. We demonstrate the necessary platform components: photon-pair generation, single-photon detection, and high-visibility quantum interference, all at wavelengths beyond 2 μm. Across various regimes, we observe a maximum net coincidence rate of 448±12Hz, a coincidence-to-accidental ratio of 25.7±1.1, and a net two-photon quantum interference visibility of 0.993±0.017. Mid-infrared silicon quantum photonics will bring new quantum applications within reach.
DOI: 10.7910/dvn/qy5r7r/k3wnt7
title: TwoModelAnalysis.do

description: Stata do file for hurdle model and table outputs
DOI: 10.7910/dvn/qy5r7r/pvkvr8
title: TwoModelAnalysis.R

description: R code for data cleaning and figures/tables
DOI: 10.5517/ccdc.csd.cc240nwq
title: CCDC 1966853: Experimental Crystal Structure Determination

description: Related Article: Syed Imran Hassan, Ashanul Haque, Yassin A. Jeilani, Rashid Ilmi, Md. Serajul Haque Faizi, Imran Khan, Md. Mushtaque|2021|J.Mol.Struct.|1224|129004|doi:10.1016/j.molstruc.2020.129004
DOI: 10.5517/ccdc.csd.cc24d4b1
title: CCDC 1977872: Experimental Crystal Structure Determination

description: Related Article: Jeff M. Van Raden, Nanette N. Jarenwattananon, Lev N. Zakharov, Ramesh Jasti|2020|Chem.-Eur.J.|26|10205|doi:10.1002/chem.202001389
DOI: 10.5517/ccdc.csd.cc24dnqy
title: CCDC 1978380: Experimental Crystal Structure Determination

description: Related Article: Krzysztof A. Konieczny, Anna Szczurek, Julia Bąkowicz, Renata Siedlecka, Arkadiusz Ciesielski, Michał K. Cyrański, Ilona Turowska-Tyrk|2020|Cryst.Growth Des.|20|5061|doi:10.1021/acs.cgd.0c00245
DOI: 10.5517/ccdc.csd.cc24dnrz
title: CCDC 1978381: Experimental Crystal Structure Determination

description: Related Article: Krzysztof A. Konieczny, Anna Szczurek, Julia Bąkowicz, Renata Siedlecka, Arkadiusz Ciesielski, Michał K. Cyrański, Ilona Turowska-Tyrk|2020|Cryst.Growth Des.|20|5061|doi:10.1021/acs.cgd.0c00245
DOI: 10.5517/ccdc.csd.cc24dns0
title: CCDC 1978382: Experimental Crystal Structure Determination

description: Related Article: Krzysztof A. Konieczny, Anna Szczurek, Julia Bąkowicz, Renata Siedlecka, Arkadiusz Ciesielski, Michał K. Cyrański, Ilona Turowska-Tyrk|2020|Cryst.Growth Des.|20|5061|doi:10.1021/acs.cgd.0c00245
DOI: 10.5517/ccdc.csd.cc24dnt1
title: CCDC 1978383: Experimental Crystal Structure Determination

description: Related Article: Krzysztof A. Konieczny, Anna Szczurek, Julia Bąkowicz, Renata Siedlecka, Arkadiusz Ciesielski, Michał K. Cyrański, Ilona Turowska-Tyrk|2020|Cryst.Growth Des.|20|5061|doi:10.1021/acs.cgd.0c00245
DOI: 10.5517/ccdc.csd.cc24dnv2
title: CCDC 1978384: Experimental Crystal Structure Determination

description: Related Article: Krzysztof A. Konieczny, Anna Szczurek, Julia Bąkowicz, Renata Siedlecka, Arkadiusz Ciesielski, Michał K. Cyrański, Ilona Turowska-Tyrk|2020|Cryst.Growth Des.|20|5061|doi:10.1021/acs.cgd.0c00245
DOI: 10.5517/ccdc.csd.cc24dnw3
title: CCDC 1978385: Experimental Crystal Structure Determination

description: Related Article: Krzysztof A. Konieczny, Anna Szczurek, Julia Bąkowicz, Renata Siedlecka, Arkadiusz Ciesielski, Michał K. Cyrański, Ilona Turowska-Tyrk|2020|Cryst.Growth Des.|20|5061|doi:10.1021/acs.cgd.0c00245
DOI: 10.5517/ccdc.csd.cc24dnx4
title: CCDC 1978386: Experimental Crystal Structure Determination

description: Related Article: Krzysztof A. Konieczny, Anna Szczurek, Julia Bąkowicz, Renata Siedlecka, Arkadiusz Ciesielski, Michał K. Cyrański, Ilona Turowska-Tyrk|2020|Cryst.Growth Des.|20|5061|doi:10.1021/acs.cgd.0c00245
DOI: 10.5517/ccdc.csd.cc24dny5
title: CCDC 1978387: Experimental Crystal Structure Determination

description: Related Article: Krzysztof A. Konieczny, Anna Szczurek, Julia Bąkowicz, Renata Siedlecka, Arkadiusz Ciesielski, Michał K. Cyrański, Ilona Turowska-Tyrk|2020|Cryst.Growth Des.|20|5061|doi:10.1021/acs.cgd.0c00245
DOI: 10.5517/ccdc.csd.cc24dnz6
title: CCDC 1978388: Experimental Crystal Structure Determination

description: Related Article: Krzysztof A. Konieczny, Anna Szczurek, Julia Bąkowicz, Renata Siedlecka, Arkadiusz Ciesielski, Michał K. Cyrański, Ilona Turowska-Tyrk|2020|Cryst.Growth Des.|20|5061|doi:10.1021/acs.cgd.0c00245
DOI: 10.5517/ccdc.csd.cc24dp08
title: CCDC 1978389: Experimental Crystal Structure Determination

description: Related Article: Krzysztof A. Konieczny, Anna Szczurek, Julia Bąkowicz, Renata Siedlecka, Arkadiusz Ciesielski, Michał K. Cyrański, Ilona Turowska-Tyrk|2020|Cryst.Growth Des.|20|5061|doi:10.1021/acs.cgd.0c00245
DOI: 10.5517/ccdc.csd.cc24dp19
title: CCDC 1978390: Experimental Crystal Structure Determination

description: Related Article: Krzysztof A. Konieczny, Anna Szczurek, Julia Bąkowicz, Renata Siedlecka, Arkadiusz Ciesielski, Michał K. Cyrański, Ilona Turowska-Tyrk|2020|Cryst.Growth Des.|20|5061|doi:10.1021/acs.cgd.0c00245
DOI: 10.5517/ccdc.csd.cc24dp2b
title: CCDC 1978391: Experimental Crystal Structure Determination

description: Related Article: Krzysztof A. Konieczny, Anna Szczurek, Julia Bąkowicz, Renata Siedlecka, Arkadiusz Ciesielski, Michał K. Cyrański, Ilona Turowska-Tyrk|2020|Cryst.Growth Des.|20|5061|doi:10.1021/acs.cgd.0c00245
DOI: 10.5517/ccdc.csd.cc24dp3c
title: CCDC 1978392: Experimental Crystal Structure Determination

description: Related Article: Krzysztof A. Konieczny, Anna Szczurek, Julia Bąkowicz, Renata Siedlecka, Arkadiusz Ciesielski, Michał K. Cyrański, Ilona Turowska-Tyrk|2020|Cryst.Growth Des.|20|5061|doi:10.1021/acs.cgd.0c00245
DOI: 10.5517/ccdc.csd.cc257sw3
title: CCDC 2003495: Experimental Crystal Structure Determination

description: Related Article: Steffen L. Woltering, Przemyslaw Gawel, Kirsten E. Christensen, Amber L. Thompson, Harry L. Anderson|2020|J.Am.Chem.Soc.|142|13523|doi:10.1021/jacs.0c05308
DOI: 10.5517/ccdc.csd.cc257sx4
title: CCDC 2003496: Experimental Crystal Structure Determination

description: Related Article: Steffen L. Woltering, Przemyslaw Gawel, Kirsten E. Christensen, Amber L. Thompson, Harry L. Anderson|2020|J.Am.Chem.Soc.|142|13523|doi:10.1021/jacs.0c05308
DOI: 10.5517/ccdc.csd.cc257sy5
title: CCDC 2003497: Experimental Crystal Structure Determination

description: Related Article: Steffen L. Woltering, Przemyslaw Gawel, Kirsten E. Christensen, Amber L. Thompson, Harry L. Anderson|2020|J.Am.Chem.Soc.|142|13523|doi:10.1021/jacs.0c05308
DOI: 10.5517/ccdc.csd.cc257sz6
title: CCDC 2003498: Experimental Crystal Structure Determination

description: Related Article: Steffen L. Woltering, Przemyslaw Gawel, Kirsten E. Christensen, Amber L. Thompson, Harry L. Anderson|2020|J.Am.Chem.Soc.|142|13523|doi:10.1021/jacs.0c05308
DOI: 10.5517/ccdc.csd.cc257t08
title: CCDC 2003499: Experimental Crystal Structure Determination

description: Related Article: Steffen L. Woltering, Przemyslaw Gawel, Kirsten E. Christensen, Amber L. Thompson, Harry L. Anderson|2020|J.Am.Chem.Soc.|142|13523|doi:10.1021/jacs.0c05308
DOI: 10.5517/ccdc.csd.cc25b2qb
title: CCDC 2005691: Experimental Crystal Structure Determination

description: Related Article: Yan Su, Yuejuan Wan, Hong Xu, Ken-ichi Otake, Xiaohui Tang, Liangbin Huang, Susumu Kitagawa, Cheng Gu|2020|J.Am.Chem.Soc.|142|13316|doi:10.1021/jacs.0c05970
DOI: 10.5517/ccdc.csd.cc237l43
title: CCDC 1943704: Experimental Crystal Structure Determination

description: Related Article: Delong Mu,  Wei Yuan,  Shuyou Chen,  Na Wang,  Bo Yang,  Lijun You,  Bing Zu,  Peiyuan Yu,  Chuan He|2020|J.Am.Chem.Soc.|142|13459|doi:10.1021/jacs.0c04863
DOI: 10.5517/ccdc.csd.cc25c7jb
title: CCDC 2006801: Experimental Crystal Structure Determination

description: Related Article: Feng Shen, Long Lu, Qilong Shen|2020|Chemical Science|11|8020|doi:10.1039/D0SC03039B
DOI: 10.5517/ccdc.csd.cc25dpz8
title: CCDC 2008210: Experimental Crystal Structure Determination

description: Related Article: Delong Mu,  Wei Yuan,  Shuyou Chen,  Na Wang,  Bo Yang,  Lijun You,  Bing Zu,  Peiyuan Yu,  Chuan He|2020|J.Am.Chem.Soc.|142|13459|doi:10.1021/jacs.0c04863
DOI: 10.5517/ccdc.csd.cc25dq0b
title: CCDC 2008211: Experimental Crystal Structure Determination

description: Related Article: Delong Mu,  Wei Yuan,  Shuyou Chen,  Na Wang,  Bo Yang,  Lijun You,  Bing Zu,  Peiyuan Yu,  Chuan He|2020|J.Am.Chem.Soc.|142|13459|doi:10.1021/jacs.0c04863
DOI: 10.34740/kaggle/dsv/1439824
title: COVID-19 Indonesia Dataset
DOI: 10.7910/dvn/30mvd1/efdlrw
title: 2020PGY_CovidGuatemalaKAPStudyBrief.pdf

description: :unav
DOI: 10.34740/kaggle/dsv/1439828
title: YouTube Trending Video Dataset (updated daily)
DOI: 10.5281/zenodo.3997702
title: wrong

description: Refactoring Dataset and Analysis Packages
DOI: 10.5281/zenodo.3997701
title: wrong

description: Refactoring Dataset and Analysis Packages
DOI: 10.5281/zenodo.3755861
title: Analysis Of Monthly And Daily Annual Extreme Precipitation For Vadodara

description: Processed data for analysis 1 Monthly One day Extreme Rainfall IMD 2 Station wise Average Annual Rainfall SWDC 3 Station wise Number of Extreme Events (P95) SWDC 4 Urban Rural Moving Average Rainfall Ratio SWDC
description: Original daily rainfall time series data used for the analysis is purchased/obtained with undertaking from the India Meteorological Department, Gujarat State Water Data Center and The Maharaja Sayajirao University of Baroda meteorological observatory.
DOI: 10.5281/zenodo.3764788
title: Analysis Of Monthly And Daily Annual Extreme Precipitation For Vadodara

description: Processed data for analysis 1 Monthly One day Extreme Rainfall IMD 2 Station wise Average Annual Rainfall SWDC 3 Station wise Number of Extreme Events (P95) SWDC 4 Urban Rural Moving Average Rainfall Ratio SWDC 5 Generalized extreme value distribution (IMD)
description: Original daily rainfall time series data used for the analysis is purchased/obtained with undertaking from the India Meteorological Department (http://dsp.imdpune.gov.in/), Gujarat State Water Data Center (https://swhydrology.gujarat.gov.in/hydrodata) and The Maharaja Sayajirao University of Baroda meteorological observatory which is a local observatory providing meteorological data to IMD.
DOI: 10.5281/zenodo.3755710
title: Analysis Of Monthly And Daily Annual Extreme Precipitation For Vadodara

description: Processed data for analysis 1 Monthly One day Extreme Rainfall IMD 2 Station wise Average Annual Rainfall SWDC 3 Station wise Number of Extreme Events (P95) SWDC 4 Urban Rural Moving Average Rainfall Ratio SWDC 5 Generalized extreme value distribution (IMD)
description: Original daily rainfall time series data used for the analysis is purchased/obtained with undertaking from the India Meteorological Department (http://dsp.imdpune.gov.in/), Gujarat State Water Data Center (https://swhydrology.gujarat.gov.in/hydrodata) and The Maharaja Sayajirao University of Baroda meteorological observatory which is a local observatory providing meteorological data to IMD.
DOI: 10.6084/m9.figshare.12854228.v1
title: R0186_20170830a_videos

description: Rat 0186, skilled reaching data collected on 8/30/2017 in Leventhal laboratory by Alexandra Bova
DOI: 10.5281/zenodo.3990545
title: Star formation and morphological properties of galaxies in the P\lowercase{an}-STARRS 3$\pi$ survey- I.\\ A machine learning approach to galaxy and supernova classification

description: <pre>This is the catalog presented in Baldeschi, et al (2020). The catalog is subdivided in 13 csv files. Files description: First column: Panstar ID (integer) Second column: Right ascension [deg] (float) Third column: Declination [deg] (float) Fourth column: Probability for a source of being a star (P_star) (float) Fifth column: Probability for a galaxy of being higly star-forming (P_HSFF) (float) Sixth column: Probability for a galaxy of being spiral (P_spiral) (float) seventh column: Compleatness flag (string) If using this catalog for publications, please cite Baldeschi, et al (2020). Fourth column values are from Tachibana & Miller (2018). For a detailed description of the columns we refer to the Appendix A of Baldeschi, et al (2020).</pre>
DOI: 10.5281/zenodo.3990544
title: Star formation and morphological properties of galaxies in the P\lowercase{an}-STARRS 3$\pi$ survey- I.\\ A machine learning approach to galaxy and supernova classification

description: <pre>This is the catalog presented in Baldeschi, et al (2020). The catalog is subdivided in 13 csv files. Files description: First column: Panstar ID (integer) Second column: Right ascension [deg] (float) Third column: Declination [deg] (float) Fourth column: Probability for a source of being a star (P_star) (float) Fifth column: Probability for a galaxy of being higly star-forming (P_HSFF) (float) Sixth column: Probability for a galaxy of being spiral (P_spiral) (float) seventh column: Compleatness flag (string) If using this catalog for publications, please cite Baldeschi, et al (2020). Fourth column values are from Tachibana & Miller (2018). For a detailed description of the columns we refer to the Appendix A of Baldeschi, et al (2020).</pre>
DOI: 10.5281/zenodo.3992624
title: Data set and software for 2020JC016485

description: This is data set in support of publication in JGR 2020JC016485
DOI: 10.5281/zenodo.3992623
title: Data set and software for 2020JC016485

description: This is data set in support of publication in JGR 2020JC016485
DOI: 10.5281/zenodo.3997351
title: Satellite Data for Corn and Soybean Fields + Other Land Cover: Illinois, US, 2017-2019

description: These are the datasets associated with the paper:<br> Hannah Kerner, Ritvik Sahajpal, Sergii Skakun, Inbal Becker-Reshef, Brian Barker, Mehdi Hosseini, Estefania Puricelli, and Patrick Gray. 2020. Resilient In-Season Crop Type Classification in Multispectral Satellite Observations using Growth Stage Normalization. In <em>KDD ’20: ACM Special Interest Group (SIG) on Knowledge Discovery and Data Mining Conference Workshops</em>, August 23–27, 2020, San Diego, CA. The code that uses these datasets can be found at: https://github.com/nasaharvest/croptype-mapping-gsn
DOI: 10.5281/zenodo.3997350
title: Satellite Data for Corn and Soybean Fields + Other Land Cover: Illinois, US, 2017-2019

description: These are the datasets associated with the paper:<br> Hannah Kerner, Ritvik Sahajpal, Sergii Skakun, Inbal Becker-Reshef, Brian Barker, Mehdi Hosseini, Estefania Puricelli, and Patrick Gray. 2020. Resilient In-Season Crop Type Classification in Multispectral Satellite Observations using Growth Stage Normalization. In <em>KDD ’20: ACM Special Interest Group (SIG) on Knowledge Discovery and Data Mining Conference Workshops</em>, August 23–27, 2020, San Diego, CA. The code that uses these datasets can be found at: https://github.com/nasaharvest/croptype-mapping-gsn
DOI: 10.5517/ccdc.csd.cc24dp4d
title: CCDC 1978393: Experimental Crystal Structure Determination

description: Related Article: Krzysztof A. Konieczny, Anna Szczurek, Julia Bąkowicz, Renata Siedlecka, Arkadiusz Ciesielski, Michał K. Cyrański, Ilona Turowska-Tyrk|2020|Cryst.Growth Des.|20|5061|doi:10.1021/acs.cgd.0c00245
DOI: 10.5517/ccdc.csd.cc24dp5f
title: CCDC 1978394: Experimental Crystal Structure Determination

description: Related Article: Krzysztof A. Konieczny, Anna Szczurek, Julia Bąkowicz, Renata Siedlecka, Arkadiusz Ciesielski, Michał K. Cyrański, Ilona Turowska-Tyrk|2020|Cryst.Growth Des.|20|5061|doi:10.1021/acs.cgd.0c00245
DOI: 10.5517/ccdc.csd.cc24dp6g
title: CCDC 1978395: Experimental Crystal Structure Determination

description: Related Article: Krzysztof A. Konieczny, Anna Szczurek, Julia Bąkowicz, Renata Siedlecka, Arkadiusz Ciesielski, Michał K. Cyrański, Ilona Turowska-Tyrk|2020|Cryst.Growth Des.|20|5061|doi:10.1021/acs.cgd.0c00245
DOI: 10.5517/ccdc.csd.cc24dp7h
title: CCDC 1978396: Experimental Crystal Structure Determination

description: Related Article: Krzysztof A. Konieczny, Anna Szczurek, Julia Bąkowicz, Renata Siedlecka, Arkadiusz Ciesielski, Michał K. Cyrański, Ilona Turowska-Tyrk|2020|Cryst.Growth Des.|20|5061|doi:10.1021/acs.cgd.0c00245
DOI: 10.5517/ccdc.csd.cc24dp8j
title: CCDC 1978397: Experimental Crystal Structure Determination

description: Related Article: Krzysztof A. Konieczny, Anna Szczurek, Julia Bąkowicz, Renata Siedlecka, Arkadiusz Ciesielski, Michał K. Cyrański, Ilona Turowska-Tyrk|2020|Cryst.Growth Des.|20|5061|doi:10.1021/acs.cgd.0c00245
DOI: 10.5517/ccdc.csd.cc24dp9k
title: CCDC 1978398: Experimental Crystal Structure Determination

description: Related Article: Krzysztof A. Konieczny, Anna Szczurek, Julia Bąkowicz, Renata Siedlecka, Arkadiusz Ciesielski, Michał K. Cyrański, Ilona Turowska-Tyrk|2020|Cryst.Growth Des.|20|5061|doi:10.1021/acs.cgd.0c00245
DOI: 10.5517/ccdc.csd.cc24y8ft
title: CCDC 1994336: Experimental Crystal Structure Determination

description: Related Article: Haipeng Lu, Chuanxiao Xiao, Ruyi Song, Tianyang Li, Annalise E. Maughan, Andrew Levin, Roman Brunecky, Joseph J. Berry, David B. Mitzi, Volker Blum, Matthew C. Beard|2020|J.Am.Chem.Soc.|142|13030|doi:10.1021/jacs.0c03899
DOI: 10.5517/ccdc.csd.cc24y8gv
title: CCDC 1994337: Experimental Crystal Structure Determination

description: Related Article: Haipeng Lu, Chuanxiao Xiao, Ruyi Song, Tianyang Li, Annalise E. Maughan, Andrew Levin, Roman Brunecky, Joseph J. Berry, David B. Mitzi, Volker Blum, Matthew C. Beard|2020|J.Am.Chem.Soc.|142|13030|doi:10.1021/jacs.0c03899
DOI: 10.5517/ccdc.csd.cc24y8hw
title: CCDC 1994338: Experimental Crystal Structure Determination

description: Related Article: Haipeng Lu, Chuanxiao Xiao, Ruyi Song, Tianyang Li, Annalise E. Maughan, Andrew Levin, Roman Brunecky, Joseph J. Berry, David B. Mitzi, Volker Blum, Matthew C. Beard|2020|J.Am.Chem.Soc.|142|13030|doi:10.1021/jacs.0c03899
DOI: 10.5517/ccdc.csd.cc2508gy
title: CCDC 1996259: Experimental Crystal Structure Determination

description: Related Article: Yubin M. Kwon, Yuri Lee, Garrett E. Evenson, Timothy A. Jackson, Dong Wang|2020|J.Am.Chem.Soc.|142|13435|doi:10.1021/jacs.0c04368
DOI: 10.5517/ccdc.csd.cc250d5s
title: CCDC 1996374: Experimental Crystal Structure Determination

description: Related Article: Xiaomei Chen, Li Ding, Yuan Tao, Christophe Pannecouque, Erik De Clercq, Chunlin Zhuang, Fen-Er Chen|2020|Eur.J.Med.Chem.|202|112549|doi:10.1016/j.ejmech.2020.112549
DOI: 10.6084/m9.figshare.12854885
title: R0187_20171007a_videos

description: Rat 0187, skilled reaching data collected on 10/7/2017 in Leventhal laboratory by Alexandra Bova
DOI: 10.6084/m9.figshare.12854885.v1
title: R0187_20171007a_videos

description: Rat 0187, skilled reaching data collected on 10/7/2017 in Leventhal laboratory by Alexandra Bova
DOI: 10.24431/rw1k46r
title: Small scale abundance and movement of Atka mackerel and other Steller sea lion groundfish prey in the Western Aleutian Islands

description: The dataset was collected in the central and western Aleutian Islands, Alaska during 2014 and 2015 as part of a large-scale tagging effort to estimate Atka mackerel abundance and movement at several locales. The dataset describes locations and lengths of tagged fish as well as conductivity, salinity, and temperature data. The dataset consists of 9 files: 1305_TagsRecovered.csv 1305_TagsReleased.csv 1305_Specimen.csv 1305_SeededTags.csv 1305_Mortality.csv 1305_MasterHaul.csv 1305_Lengths.csv 1305_CTD.csv 1305_Catch.csv
DOI: 10.6084/m9.figshare.12857474
title: Dataset for cocoa export.rar

description: This file contain an export datasets for Nigerian cocoa.
DOI: 10.15468/rvjmgg
title: On the Nepalota fauna of China II. Two new synonymies and an additional record (Coleoptera: Staphylinidae: Aleocharinae)

description: This dataset contains the digitized treatments in Plazi based on the original journal article Assing, Volker (2018): On the Nepalota fauna of China II. Two new synonymies and an additional record (Coleoptera: Staphylinidae: Aleocharinae). Linzer biologische Beiträge 50 (1): 65-66, DOI: http://doi.org/10.5281/zenodo.3985267
DOI: 10.5281/zenodo.3997982
title: The Ubiquitin Ligase WWP1 Contributes to Shifts in Matrix Proteolytic Profiles and a Myocardial Aging Phenotype with Diastolic Heart Failure

description: <strong><em>Aims</em></strong>. Ubiquitylation is a key event that regulates protein turnover, and induction of the ubiquitin ligase E3 WWP1 has been associated with age. Left ventricular hypertrophy (LVH) commonly occurs as a function of age and can cause heart failure with a preserved ejection fraction (EF; HFpEF). We hypothesized that overexpression (O/E) of WWP1 in the heart would cause LVH as well as functional and structural changes consistent with the aging HFpEF phenotype. <strong><em>Methods and Results.</em></strong> Global WWP1 O/E was achieved in mice (n=11) and echocardiography (40 MHz) performed to measure LV mass, EF, Doppler velocities (early-E, late/atrial-A), myocardial relaxation (E’), and isovolumetric relaxation time (IVRT) at 4, 6, and 8 weeks. Age matched wild type animals (n=15) were included as referent controls. LV EF was identical (60+1% vs 60+1%, p&gt;0.90) with no difference in LV mass (67+3 vs 75+5, p&gt;0.25) at 4 weeks. However, at 8 weeks of age, LV mass increased by over two-fold, E/A fell (impaired passive filling), and E/E’ was lower and IVRT prolonged (impaired LV relaxation) - all p&lt;0.05. Collagen percent area increased by over two-fold and fibrillar collagen expression (rtPCR) by over 1.5 fold (p&lt;0.05) with WWP1 O/E. WWP1 with an anti-WWP1 antibody could be identified in isolated cardiac fibroblasts with WWP1 increased by over two-fold in O/E fibroblasts (p&lt;0.05). <strong><em>Conclusion.</em></strong> Inducing WWP1 expression caused LVH, preserved systolic function, but impaired diastolic dysfunction, consistent with the HFpEF phenotype. Targeting the WWP1 pathway may be a novel therapeutic target for this intractable form of HF associated with aging.
DOI: 10.5281/zenodo.3997981
title: The Ubiquitin Ligase WWP1 Contributes to Shifts in Matrix Proteolytic Profiles and a Myocardial Aging Phenotype with Diastolic Heart Failure

description: <strong><em>Aims</em></strong>. Ubiquitylation is a key event that regulates protein turnover, and induction of the ubiquitin ligase E3 WWP1 has been associated with age. Left ventricular hypertrophy (LVH) commonly occurs as a function of age and can cause heart failure with a preserved ejection fraction (EF; HFpEF). We hypothesized that overexpression (O/E) of WWP1 in the heart would cause LVH as well as functional and structural changes consistent with the aging HFpEF phenotype. <strong><em>Methods and Results.</em></strong> Global WWP1 O/E was achieved in mice (n=11) and echocardiography (40 MHz) performed to measure LV mass, EF, Doppler velocities (early-E, late/atrial-A), myocardial relaxation (E’), and isovolumetric relaxation time (IVRT) at 4, 6, and 8 weeks. Age matched wild type animals (n=15) were included as referent controls. LV EF was identical (60+1% vs 60+1%, p&gt;0.90) with no difference in LV mass (67+3 vs 75+5, p&gt;0.25) at 4 weeks. However, at 8 weeks of age, LV mass increased by over two-fold, E/A fell (impaired passive filling), and E/E’ was lower and IVRT prolonged (impaired LV relaxation) - all p&lt;0.05. Collagen percent area increased by over two-fold and fibrillar collagen expression (rtPCR) by over 1.5 fold (p&lt;0.05) with WWP1 O/E. WWP1 with an anti-WWP1 antibody could be identified in isolated cardiac fibroblasts with WWP1 increased by over two-fold in O/E fibroblasts (p&lt;0.05). <strong><em>Conclusion.</em></strong> Inducing WWP1 expression caused LVH, preserved systolic function, but impaired diastolic dysfunction, consistent with the HFpEF phenotype. Targeting the WWP1 pathway may be a novel therapeutic target for this intractable form of HF associated with aging.