cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.15468/dl.khp98f
title: Occurrence Download

description: A dataset containing 362 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is Chile",
 "TaxonKey is Liolaemus nigroviridis Müller & Hellmich, 1932",
 "Year 1950-2025"
 ]
}

 The dataset includes 362 records from 9 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0009731-250525065834625/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.jttr65
title: Occurrence Download

description: A dataset containing 7233 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Helenium flexuosum Raf."
 ]
}

 The dataset includes 7233 records from 183 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0009729-250525065834625/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.8nry3t
title: Occurrence Download

description: A dataset containing 148 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is China",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 "TaxonKey is Lycium ruthenicum Murray"
 ]
}

 The dataset includes 148 records from 11 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0006604-250525065834625/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.5284/1125810
title: Digital Archive from an Archaeological Evaluation at New Street, Stradbroke, Suffolk, September-October 2020

description: This collection comprises images, reports, and site records from an archaeological evaluation on the land south of New Street, Stradbroke, Suffolk. This work was undertaken by Pre-Construct Archaeology Ltd. in September and October 2020. The earliest dated features were two shallow, intercutting pits from which were recovered four small sherds of pottery. The sherds had no diagnostic features, but their fabric suggests that they may be Early Saxon in date although the similarity in the fabric type to some Iron Age pottery fabrics precludes definitive dating of the pottery. There was also a system of small ditches possibly associated with an east to west-aligned ditch to the south. Finally, there was a large post-medieval ditch that corresponds with a boundary shown on the 1840 Tithe map of the area, bordering the eastern edge of a former lane that once linked New Street with Wilby Road.
DOI: 10.15468/dl.qmzzaz
title: Occurrence Download

description: A dataset containing 7509 species occurrences available in GBIF matching the query:
{
 "and" : [
 "BasisOfRecord is one of (Material sample, Specimen, Fossil, Living Specimen)",
 "InstitutionKey is 1e987829-19c2-44ec-88ae-59fca0e35302",
 "OccurrenceStatus is Present"
 ]
}

 The dataset includes 7509 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0007067-250525065834625/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.17632/pwyxg7kfzm
title: Microtremor data

description: 微动数据
DOI: 10.17632/pwyxg7kfzm.1
title: Microtremor data

description: 微动数据
DOI: 10.17632/2j8vfhy8zx
title: For paper about DRN GABAergic neurons

description: GABAergic neurons in the dorsal raphe nuclei are involved in the regulation of social hierarchy in mice
DOI: 10.17632/2j8vfhy8zx.1
title: For paper about DRN GABAergic neurons

description: GABAergic neurons in the dorsal raphe nuclei are involved in the regulation of social hierarchy in mice
DOI: 10.6084/m9.figshare.28468408
title: Bee bread shows therapeutic and protective effects by alleviating inflammation, oxidative stress, and apoptosis on acetic acid-induced gastric ulcer in rats

description: This study investigated bee bread’s (BB) protective and therapeutic effects on acetic acid-(AA)-induced gastric ulcers via oxidative stress, DNA damage, inflammation, and apoptosis. Rats were administered saline-(1ml) or BB-(0.5g/kg/day;1ml) by oral gavage once daily for 10-day following 80% AA-induced chronic ulceration in treatment group. Pretreatment group received saline or BB for 10-day before and 3-day after ulcer induction. Stomachs of decapitated rats were collected for ulcer index, histological and biochemical analyses. BB significantly reduced the gastric ulcer index and levels of chemiluminescence, HMGB-1, IL-6, IL-1ß and IL-8 levels in pretreatment and treatment groups. In BB-pretreated ulcer group, MPO-(saline\BB, 39.9±3.7 U/g;22.2±2.2 U/g), caspase-3 (0.40±0.07 ng/g;0.18±0.01 ng/g) and IFN-γ (15.46±1.76;9.51±1.95 ng/g) levels decreased and TNF-α (31.77±5.13;18.94±2.59 ng/g) reduced only in BB-treated ulcer group. MDA, GSH, NRF-2, and 8-OHdG levels remained unchanged. BB has demonstrated protective and therapeutic effects by reducing ROS production, modulating inflammation and apoptosis. Bee bread has high amounts of apigenin, quercetin, galangin, p-coumaric acid and lower amounts of ferulic acid, caffeic acid, and chrysin along with high antioxidant capacity.Bee bread has the capacity to reduce microscopic and macroscopic reduction of ulcerated gastric tissue damage, and its capacity is associated with a significant protective effect on the gastric mucosa.The beneficial effect of bee bread on gastric mucosa was found to be mediated by the inhibition of excessive ROS production, suppression of inflammatory response and down-regulation of apoptosis. Bee bread has high amounts of apigenin, quercetin, galangin, p-coumaric acid and lower amounts of ferulic acid, caffeic acid, and chrysin along with high antioxidant capacity. Bee bread has the capacity to reduce microscopic and macroscopic reduction of ulcerated gastric tissue damage, and its capacity is associated with a significant protective effect on the gastric mucosa. The beneficial effect of bee bread on gastric mucosa was found to be mediated by the inhibition of excessive ROS production, suppression of inflammatory response and down-regulation of apoptosis.
DOI: 10.6084/m9.figshare.28468408.v1
title: Bee bread shows therapeutic and protective effects by alleviating inflammation, oxidative stress, and apoptosis on acetic acid-induced gastric ulcer in rats

description: This study investigated bee bread’s (BB) protective and therapeutic effects on acetic acid-(AA)-induced gastric ulcers via oxidative stress, DNA damage, inflammation, and apoptosis. Rats were administered saline-(1ml) or BB-(0.5g/kg/day;1ml) by oral gavage once daily for 10-day following 80% AA-induced chronic ulceration in treatment group. Pretreatment group received saline or BB for 10-day before and 3-day after ulcer induction. Stomachs of decapitated rats were collected for ulcer index, histological and biochemical analyses. BB significantly reduced the gastric ulcer index and levels of chemiluminescence, HMGB-1, IL-6, IL-1ß and IL-8 levels in pretreatment and treatment groups. In BB-pretreated ulcer group, MPO-(saline\BB, 39.9±3.7 U/g;22.2±2.2 U/g), caspase-3 (0.40±0.07 ng/g;0.18±0.01 ng/g) and IFN-γ (15.46±1.76;9.51±1.95 ng/g) levels decreased and TNF-α (31.77±5.13;18.94±2.59 ng/g) reduced only in BB-treated ulcer group. MDA, GSH, NRF-2, and 8-OHdG levels remained unchanged. BB has demonstrated protective and therapeutic effects by reducing ROS production, modulating inflammation and apoptosis. Bee bread has high amounts of apigenin, quercetin, galangin, p-coumaric acid and lower amounts of ferulic acid, caffeic acid, and chrysin along with high antioxidant capacity.Bee bread has the capacity to reduce microscopic and macroscopic reduction of ulcerated gastric tissue damage, and its capacity is associated with a significant protective effect on the gastric mucosa.The beneficial effect of bee bread on gastric mucosa was found to be mediated by the inhibition of excessive ROS production, suppression of inflammatory response and down-regulation of apoptosis. Bee bread has high amounts of apigenin, quercetin, galangin, p-coumaric acid and lower amounts of ferulic acid, caffeic acid, and chrysin along with high antioxidant capacity. Bee bread has the capacity to reduce microscopic and macroscopic reduction of ulcerated gastric tissue damage, and its capacity is associated with a significant protective effect on the gastric mucosa. The beneficial effect of bee bread on gastric mucosa was found to be mediated by the inhibition of excessive ROS production, suppression of inflammatory response and down-regulation of apoptosis.
DOI: 10.6084/m9.figshare.28172394
title: Reduced lipid and glucose oxidation and reduced lipid synthesis in AMPKα2<sup>-/-</sup> myotubes

description: Adenosine 5’-monophosphate (AMP)-activated protein kinase (AMPK) plays a crucial role in regulation of metabolic homeostasis. To understand the role of the catalytic α2 subunit of AMPK in skeletal muscle energy metabolism, myotube cultures were established from <i>AMPKα2<sup>+/+</sup></i> and <i>AMPKα2<sup>-/-</sup></i> mice. Myotubes from <i>AMPKα2<sup>-/-</sup></i> mice had lower basal oleic acid and glucose oxidation compared to myotubes from <i>AMPKα2<sup>+/+</sup></i> mice. However, the relative response to mitochondrial uncoupling was increased for oleic acid oxidation. Incorporation of acetate into lipids was also lower in myotubes from <i>AMPKα2<sup>-/-</sup></i> mice. Proteomics analysis revealed that <i>AMPKα2<sup>-/-</sup></i> myotubes had upregulated pathways related to mitochondrial function and fatty acid oxidation, and decreased pathways related to fatty acid biosynthesis. In conclusion, ablation of AMPKα2 catalytic subunit in skeletal muscle cells resulted in reduced basal oxidation of glucose and fatty acids, however upregulated pathways related to mitochondrial function and fatty acid oxidation and reduced lipid formation.
DOI: 10.6084/m9.figshare.28172394.v1
title: Reduced lipid and glucose oxidation and reduced lipid synthesis in AMPKα2<sup>-/-</sup> myotubes

description: Adenosine 5’-monophosphate (AMP)-activated protein kinase (AMPK) plays a crucial role in regulation of metabolic homeostasis. To understand the role of the catalytic α2 subunit of AMPK in skeletal muscle energy metabolism, myotube cultures were established from <i>AMPKα2<sup>+/+</sup></i> and <i>AMPKα2<sup>-/-</sup></i> mice. Myotubes from <i>AMPKα2<sup>-/-</sup></i> mice had lower basal oleic acid and glucose oxidation compared to myotubes from <i>AMPKα2<sup>+/+</sup></i> mice. However, the relative response to mitochondrial uncoupling was increased for oleic acid oxidation. Incorporation of acetate into lipids was also lower in myotubes from <i>AMPKα2<sup>-/-</sup></i> mice. Proteomics analysis revealed that <i>AMPKα2<sup>-/-</sup></i> myotubes had upregulated pathways related to mitochondrial function and fatty acid oxidation, and decreased pathways related to fatty acid biosynthesis. In conclusion, ablation of AMPKα2 catalytic subunit in skeletal muscle cells resulted in reduced basal oxidation of glucose and fatty acids, however upregulated pathways related to mitochondrial function and fatty acid oxidation and reduced lipid formation.
DOI: 10.6084/m9.figshare.28407619
title: Lepidine potentiates the antidiabetic effect of metformin in nicotinamide/streptozotocin-induced diabetic male rats

description: Metformin is used as a first-line treatment of type 2 diabetes mellitus (T2DM) and is effective as monotherapy and in combination with other glucose-lowering medications. Lepidine, a natural product found in <i>Lepidium sativum</i>, had antidiabetic, antioxidant, anticancer, anti-inflammatory, and hypolipidemic effects. This study aimed to assess the effects of lepidine alone and in combination with metformin in nicotinamide (NA)/streptozotocin (STZ)-induced diabetic Wistar rats. T2DM was induced by intraperitoneal injection of NA 15 minutes before intraperitoneal injection of STZ. Diabetic rats were orally treated with lepidine (20 mg/kg body weight) and/or metformin (70 mg/kg body weight) every other day for four weeks. Both lepidine and metformin treated diabetic rats showed a significant decrease in fasting blood glucose (FBG), amelioration of serum lipid profile, increase in serum insulin, and C-peptide , and downregulation in the elevated serum tumour necrosis α (TNF-α) level in association with the improvement in the pancreatic islet integrity and function. In conclusion, the lepidine has potent anti-diabetic effects and may add more to the therapeutic value of metformin when the two agents are used in combination. However, further clinical studies on human beings with T2DM are required to assess the efficacy and safety of the combination of metformin and lepidine before its approval and therapeutic application.
DOI: 10.6084/m9.figshare.28407619.v1
title: Lepidine potentiates the antidiabetic effect of metformin in nicotinamide/streptozotocin-induced diabetic male rats

description: Metformin is used as a first-line treatment of type 2 diabetes mellitus (T2DM) and is effective as monotherapy and in combination with other glucose-lowering medications. Lepidine, a natural product found in <i>Lepidium sativum</i>, had antidiabetic, antioxidant, anticancer, anti-inflammatory, and hypolipidemic effects. This study aimed to assess the effects of lepidine alone and in combination with metformin in nicotinamide (NA)/streptozotocin (STZ)-induced diabetic Wistar rats. T2DM was induced by intraperitoneal injection of NA 15 minutes before intraperitoneal injection of STZ. Diabetic rats were orally treated with lepidine (20 mg/kg body weight) and/or metformin (70 mg/kg body weight) every other day for four weeks. Both lepidine and metformin treated diabetic rats showed a significant decrease in fasting blood glucose (FBG), amelioration of serum lipid profile, increase in serum insulin, and C-peptide , and downregulation in the elevated serum tumour necrosis α (TNF-α) level in association with the improvement in the pancreatic islet integrity and function. In conclusion, the lepidine has potent anti-diabetic effects and may add more to the therapeutic value of metformin when the two agents are used in combination. However, further clinical studies on human beings with T2DM are required to assess the efficacy and safety of the combination of metformin and lepidine before its approval and therapeutic application.
DOI: 10.6084/m9.figshare.31111788
title: “Boring People Doing Boring Jobs”: High School Educators’ Conceptions of Technical Writing and Technical Communication

description: This study explores high school educators’ perceptions of technical writing and communication and their impact on higher education recruitment. A survey of 213 educators revealed narrow, outdated views, with most linking the field only to instructions and procedures. Few identified their teaching as technical writing. However, a brief definitional intervention increased recognition and willingness to promote the field, suggesting that low-stakes efforts may improve awareness along the high school-college pipeline.
DOI: 10.6084/m9.figshare.31111788.v1
title: “Boring People Doing Boring Jobs”: High School Educators’ Conceptions of Technical Writing and Technical Communication

description: This study explores high school educators’ perceptions of technical writing and communication and their impact on higher education recruitment. A survey of 213 educators revealed narrow, outdated views, with most linking the field only to instructions and procedures. Few identified their teaching as technical writing. However, a brief definitional intervention increased recognition and willingness to promote the field, suggesting that low-stakes efforts may improve awareness along the high school-college pipeline.
DOI: 10.6084/m9.figshare.31111765
title: Datos X/Twitter #saludmental

description: Data #SaludMental
DOI: 10.6084/m9.figshare.31111765.v1
title: Datos X/Twitter #saludmental

description: Data #SaludMental
DOI: 10.15468/dl.8pcw6z
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
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 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0002305-260120142942310/datasets/export for details.
DOI: 10.6084/m9.figshare.28408093
title: Immunophenotypical characterization of immune checkpoint receptor expression in cynomolgus monkeys and human healthy volunteers in resting and in T-cell stimulatory conditions <i>in vitro</i>

description: Immunotherapeutics targeting immune checkpoint receptors or their ligands (i.e., immune checkpoint inhibitors), have been groundbreaking in the field of oncology, radically changing the approach to treatment and improving the clinical outcomes of an ever-expanding list of solid tumors and hematological malignancies. However, immune checkpoint inhibitors (ICI) are not devoid of side effects, collectively regarded as immune-related adverse events (irAE); they are not easily uncovered in preclinical immunotoxicological investigations and are often due to the very low expression of their targets in immunologically-unchallenged non-clinical species. We have characterized expression of a broad range of immune checkpoint receptors in peripheral blood mononuclear cell (PBMC) subpopulations from cynomolgus monkeys and healthy human volunteers, under resting and T-cell stimulatory conditions by multicolor flow cytometry to inform appropriate species selection for modeling potential irAE in immunotherapeutic preclinical research. Focusing on the response of the main lymphocyte populations to interleukin (IL)-2 alone, or in combination with anti-CD3 and anti-CD28 antibodies, checkpoints with shared similarities and key differences between the two species were identified. The results of this first study provide a database for the expression and response to stimulation for immune checkpoint receptors and can help guide future model selection in the design of preclinical studies involving immunotherapeutics directed against these targets.
DOI: 10.6084/m9.figshare.28408093.v2
title: Immunophenotypical characterization of immune checkpoint receptor expression in cynomolgus monkeys and human healthy volunteers in resting and in T-cell stimulatory conditions <i>in vitro</i>

description: Immunotherapeutics targeting immune checkpoint receptors or their ligands (i.e., immune checkpoint inhibitors), have been groundbreaking in the field of oncology, radically changing the approach to treatment and improving the clinical outcomes of an ever-expanding list of solid tumors and hematological malignancies. However, immune checkpoint inhibitors (ICI) are not devoid of side effects, collectively regarded as immune-related adverse events (irAE); they are not easily uncovered in preclinical immunotoxicological investigations and are often due to the very low expression of their targets in immunologically-unchallenged non-clinical species. We have characterized expression of a broad range of immune checkpoint receptors in peripheral blood mononuclear cell (PBMC) subpopulations from cynomolgus monkeys and healthy human volunteers, under resting and T-cell stimulatory conditions by multicolor flow cytometry to inform appropriate species selection for modeling potential irAE in immunotherapeutic preclinical research. Focusing on the response of the main lymphocyte populations to interleukin (IL)-2 alone, or in combination with anti-CD3 and anti-CD28 antibodies, checkpoints with shared similarities and key differences between the two species were identified. The results of this first study provide a database for the expression and response to stimulation for immune checkpoint receptors and can help guide future model selection in the design of preclinical studies involving immunotherapeutics directed against these targets.
DOI: 10.6084/m9.figshare.28408044
title: Generation of cynomolgus monkey capsid-specific positive control cells for IFNγ ELISpot assays for adeno-associated gene therapy applications

description: Cell-mediated immune (CMI) responses to adeno-associated virus (AAV) can lead to tissue damage and loss of therapeutic transgene expression. Identifying robust biomarkers and mechanisms of CMI can aid clinical practice and advancement of AAV gene therapies. The present work evaluated peripheral blood mononuclear cells (PBMC) from non-human primates (NHP) before and after immunization with adenovirus 5 encoding AAV9 capsid antigen. PBMC were stimulated <i>ex vivo</i> with AAV9 capsid peptides to evaluate CMI responses by interferon (IFN)-γ ELISpot, intracellular cytokines/activation markers, secreted cytokines, and RNAseq. AAV peptide stimulation produced a robust IFNγ ELISpot 11 days after immunization and ≈ 4 years after cryopreservation. Flow cytometry revealed increased IFNγ, interleukin (IL)-2, or tumor necrosis factor (TNF)-positive T-cells. Increases in secreted CXCR3 ligands (IP-10, I-TAC) were detected. Robust changes and correlations to ELISpot responses were revealed by RNAseq, including IFNγ, IP-10, and I-TAC, many downstream transcripts, and several IFN-independent pathways. These data from AAV-immunized NHP identify biomarkers that could serve as robust and sensitive supplements/alternatives to ELISpot for early detection of CMI responses. Assessment of these biomarkers in non-clinical and clinical studies is a critical next step to determine the translation of this work to administration of a therapeutic AAV vector.