cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.17632/9h2j5zwjst
title: SLC7A5-mediated L-Leu intake control aGVHD and GVT: metabolomics dataset

description: Metabolomics data and its univariate analysis for study:

Restriction of SLC7A5-mediated L-Leu uptake in allogenic T cells efficiently prevents acute graft-versus-host disease and maintains graft-versus tumor response.

The amino acid transporter SLC7A5, which mediates the uptake of L-Leu and other essential amino acids in activated T cells and in malignant cells, has become an important target in controlling inflammation and cancer. However, its role in acute graft-versus-host disease (aGVHD) and graft versus tumor (GVT) has not been explored before. In this study, we demonstrate that SLC7A5 genetic deletion affected the activation and proliferation of allogenic T cells, promoted apoptosis and reduced IFNγ and granzyme B secretion by CD4 and CD8 T cells. Genetic deletion of SLC7A5 completely prevented aGVHD-induced lethality in mice but did not control tumor growth. On the other hand, the administration of a L-Leu-free diet efficiently reduced aGVHD mortality in mice by controlling allogenic T cell expansion, inducing apoptosis, and affecting granzyme B secretion. However, CD8 T cells did not fail to activate and secrete IFNγ in the absence of Leu, and showed increase proportion of central memory T cells, which contributed to the GVT response. Genetic deletion of SLC7A5 in T cells severely compromises mTORC1, glycolysis and mitochondrial oxidation. However, L-Leu removal mildly reduced mTORC1 signaling, completely blocked glycolysis but enhanced mitochondrial function, favoring the generation of central memory responses and expression of stemness marker TCF1. Dietary L-Leu restriction prevented the increase of potential proinflammatory metabolites derived from tricarboxylic acid cycle and L-Leu-derived ketogenesis induced by aGVHD. Overall, this study reveals that dietary restriction of L-Leu is sufficient to target SLC7A5 in allogenic cells during aGVHD, preserving GVT response.
DOI: 10.6084/m9.figshare.5589883.v3
title: Core and surface temperature measurements of experimental animals

description: Core and surface temperature measurements of experimental animals. The dataset included core temperature measurements of 177 temperature-transponder-implanted animals and surface temperature measurements of 435 animals.<br>
DOI: 10.17632/34td4ds2r9
title: Branching topology of the human embryo transcriptome revealed by entropy sort feature weighting

description: This repository stores the data and code used to generate the human pre-implantation embryo results in our publication titled, "Branching topology of the human embryo transcriptome revealed by entropy sort feature weighting". 

The data is subset into two sub folders whose recommended order of usage is as follows:

1. Human_Embryo_Analysis - Contains the code used to generate all early human embryo scRNA-seq results in our publication. Python files with the the suffix, "_Workflow.py" contain the code required to reproduce results and plots.
2. Synthetic_Data - Contains the code used to generate all Dyngen synthetic scRNA-seq dataset results in our publication. Python files with the the suffix, "_Workflow.py" contain the code required to reproduce results and plots.

We would like to highlight that we have provided exact copies of the early human embryo scRNA-seq counts matrices used in the paper to make our work as accessible as possible. However, we recommend that researchers who wish to use the datasets we used in their own work start from the source data (e.g. the Gene Expression Omnibus repositories) to maintain their integrity. Details of each dataset used for this work are provided in the experimental procedures section of our manuscript.
DOI: 10.17632/zwfdmp5syg
title: COVID-19 Fake News Dataset

description: This dataset consists of a collection of true and fake news related to COVID-19. The dataset consists of news between the period of December 2019- July 2020.
DOI: 10.6084/m9.figshare.27822537.v2
title: <b>Protecting unaccompanied migrant youth in transit through Mexico: frontline perspectives on appropriate policy implementation</b>. Additional Data

description: Additional data for article '<b>Protecting unaccompanied migrant youth in transit through Mexico: frontline perspectives on appropriate policy implementation</b>': worker semi-structured interview topic guide and thick description of worker thematic categories
DOI: 10.17632/w5c378y49h
title: Evaluation of WHO WPRO Regional TB Framework 2016-2020

description: The information uploaded here was developed/ gathered during an evaluation of the World Health Organization's TB framework for the Western Pacific Region called Regional framework for action on implementation of the End TB Strategy in the Western Pacific, 2016–2020, conducted in 2019. The evaluation was carried out by Professor Ben Marais and Drs Kerri Viney and Chris Lowbridge, contracted by the End TB unit, WHO WPRO.
DOI: 10.17632/ntywtmc2p7
title: Data for: The Influence of Personality Traits and Order of Play on Performance: A Basketball Free Throw Field Experiment

description: Data of a basketball free throw field experiment
DOI: 10.17632/pkcjn539b5
title: PRAMP_dataset

description: Dataset used to create PRAMP algorithm, described in research paper:
Design of a stable human acid-β-glucosidase: towards improved Gaucher disease therapy and mutation classification

Sarka Pokorna, Olga Khersonsky, Rosalie Lipsh-Sokolik, Adi Goldenzweig, Rebekka Nielsen, Yacov Ashani, Yoav Peleg, Tamar Unger, Shira Albeck, Orly Dym, Asa Tirosh, Rana Tarayra, Michaël Hocquemiller, Ralph Laufer, Shifra Ben-Dor, Israel Silman, Joel L. Sussman, Sarel J. Fleishman and Anthony H. Futerman
DOI: 10.17632/sctwvw5gj7
title: NEW APPROACHES TO IRREGULAR INTEGRALS THROUGH THE THEORY OF GENERALIZED FUNCTIONS

description: In this paper, we investigate a new approach to irregular integrals through the theory of generalized functions. Traditional approaches to irregular integrals are often limited to certain classes of functions or require special techniques to solve singularities. However, through the application of the theory of generalized functions, we open the door to the integration of a wider range of functions that are not strictly defined or have singularities.
In our research, we develop new definitions of irregular integrals based on the principles of the theory of generalized functions. Using this approach, we demonstrate the possibility of integrating functions that were previously beyond the reach of traditional methods. Furthermore, we explore applications of these new definitions in various fields, including mathematics, physics, and engineering.
Our results indicate the potential advantages of this new approach, including greater flexibility when solving problems with singularities, as well as the possibility of application in complex integration problems. Through this work, we open new perspectives in the study of irregular integrals and encourage further research in this area.
Keywords: Irregular integrals, Generalized functions, Singularities, Theory of distributions, Integration of functions with singularities
DOI: 10.17632/5mkhzmswyn
title: Increased Frequency of T Peripheral Helper Cell and Plasmablast Correlates with Disease Activity in Childhood-Onset Systemic Lupus Erythematosus with Nephritis. Baxter et al.

description: Gene Expression and Module Score data from DxTerity analysis of whole blood from new-onset SLE patients as described in methods.
DOI: 10.17632/sr4dgzm9d9
title: Publications on the Financial Development and Economic Growth research

description: All 536 publications on the topic of the Financial Development and Economic Growth on Scopus for bibliometric analysis!
DOI: 10.17632/pbbfyv2zjs
title: Replication Material  ``Trade costs, home bias and the unequal gains from trade''.

description: Folder with replication material for Hillrichs, Vannoorenberghe 2022: ``Trade costs, home bias and the unequal gains from trade''.
DOI: 10.17632/xm5dr9gs9s
title: Summary of the field diary

description: Summary of the field data obtained, which was organised in relation to different patterns and factors linked to nursing accountability
DOI: 10.17632/z28wmcbt2f
title: Comparison of heart rate and heart rate recovery after six minute walk test in physically active and inactive smokers

description: Background: Smoking increases the risk of cardiovascular events and also impairs the function of heart and blood vessels. Physical activity plays a vital role in prevention of various diseases and produces lots of benefits. Objectives: The objective of the present study was to compare heart rate and heart rate recovery after six minute walk test heart rate in active and inactive smoker Methods: In this study 30 participant were included out of this 15 were active smoker and 15 were inactive smoker aged 22-35 years. After initial screening and assessment of the participant level of physical activity was assessed by using GPAQ and subjects were diivided into active and inactive group; then six minute walk test (6MWT) was conducted in bioth groups. Resting heart rate, heart rate recovery upto 5 minutes and 6MWD were recorded in both the groups. Results: The resting heart rate was significantly higher in inactive smoker as compared with active smoker (p&lt;0.05). Heart rate after 6MWT was significantly higher in inactive smoker than active smoker (p&lt;0.05). The heart rate recovery was delayed at the end of 1,2,3,4 and 5 minute of recovery in inactive smokers in comparison to active smokers (p&lt;0.05). The distance walked by active smokers was significantly higher than inactive smokers (p&lt;0.05). Conclusion: The present study concluded that the resting heart rate is higher in inactive smoker as compared to active smoker. Heart rate recovery was delayed in inactive smokers. Physical activity plays a vital role in prevention of various diseases and could decrease the detrimental effect of smoking to some extent as compared to inactive smoker.
DOI: 10.17632/923vkwfdbb
title: EconomicVietnam

description: This is a data file on urbanization, economic growth, foreign direct investment and CO2 emissions of Vietnam from 1990 to 2023. Data extracted from World Bank data on Vietnam
DOI: 10.17632/3jdywv5jrv
title: Profiling B cell immunodominance after SARS-CoV-2 infection reveals antibody evolution to non-neutralizing viral targets, Dugan et al. 2021

description: This study was designed to capture the single cell transcriptome and BCR sequence of B cells that were bait sorted using oligo-tagged viral antigens. Human B cells (viable/CD19+/antigen-PE+ or viable/CD19+/antigen-APC+) were bait sorted after initial magnetic enrichment and used in downstream sequencing. PROTOCOLS: PBMCs were isolated from whole blood (acute samples) or leukoreduction filters (convalescent samples) by use of a Lymphoprep Ficoll gradient and any contaminating red blood cells were lysed by ACK buffer. Cells were then frozen at -80 deg C in fetal bovine serum supplemented with 10% DMSO. On the day of sorting and sequencing cells were thawed and B cell were purified by human pan B cell EasySep enrichment kit from STEMCELL technologies. Cells were partitioned into nanoliter-scale Gel Bead-In-EMulsions (GEMs) to achieve single cell resolution for a maximum of 10,000 individual cells per sample. Utilizing the Chromium Single Cell A Chip Kit(10x Genomics, PN-120236) and Chromium Single Cell 5' Library & Gel Bead Kit (10x Genomics, PN-1000006) , poly-adenylated mRNA from an individual cell was tagged with a unique 16 base pair 10x barcode and 10 base pair Unique Molecular Identifier. Libraries were generated using the Chromium Single Cell 5' Feature Barcode Library Kit (10x genomics, 1000080) and the Chromium Single Cell V(D)J Enrichment Kit Human B Cell (10x Genomics, PN-1000016). The cDNA amplicon size for each library was optimized using enzymatic fragmentation and size selection and the concentration and average fragment size of each library was determined using an Agilent High Sensitivity DNA Kit (Agilent). Specifically, user guide CG000186 Rev D was used for all steps. All libraries were sequenced on an Illuina NextSeq550 or an Illumina NextSeq500 with 26 cycles apportioned for read 1, 8 cycles for the i7 index, and 134 cycles for read 2 using an NextSeq 500/550 High Output Kit v2.5 (150 Cycles). Some samples were sequenced using a NextSeq 550 housed within the Pritzker School of Molecular Engineering's Chicago Immunoengineering Innovation Center (Chicago, IL) and others on a NextSeq500 belonging to the University of Chicago Genomics Facility (Chicago, IL - RRID: SCR_019196) DATA PROCESSING PIPELINE: Demultiplexing the Illumina sequencer's base call files (BCLs) for each flowcell directory into FASTQ files was performed by "cellranger mkfastq" (cellranger version 3.02) Gene counts were calculated using "cellranger count" (cellranger version 3.02) under default setting， BCR sequences were assembled using "cellranger vdj" (cellranger version 3.02) under default setting. GRCh38-1.2.0 for transccriptome, cellranger-vdj-GRCh38-alts-ensembl-2.0.0 for V(D)J
DOI: 10.17632/92grpns4xw
title: my MRI whole Spine

description: Spine
DOI: 10.17632/jykt6862s4
title: Bee and non-bee dataset

description: We 6,332 images from iNaturalist platform  (https://www.inaturalist.org). We have trained two AI models. One is to classify bee-vs-nonbee insects and another one to classify Bumble bee vs Non-bumble bee insects. These images were used to train, validate and test our AI models.
DOI: 10.17632/kydc3zw9jb
title: Hourly wind speeds at 20 sites in the province of Quebec (Canada)

description: Hourly wind speed observation data from 20 sites in the province of Quebec (Canada). The sites have a measurement period of at least 30 years. These data were extracted from the historical climate database of Environment and Climate Change Canada (https://climate.weather.gc.ca/). [Accessed: 20-March-2020]
DOI: 10.6084/m9.figshare.25562229.v3
title: Climate Physical Risk Index (CPRI)

description: Climate Physical Risk Index (CPRI) dataset includes comprehensive climate physical risk assessment data for 170 countries, 31 Chinese provinces, and 229 Chinese cities from 1993 to 2023. The index contains four dimensions including the standardized average annual extreme low temperature days (LTD), extreme high temperature days (HTD), extreme rainfall days (ERD) and extreme drought days (EDD) of all stations in a certain region (country/province/city). The standards for extreme values of LTD, HTD, ERD, EDD are 10% quantile and 90% quantile of daily average temperature, 95% quantile of daily rainfall, and 5% quantile of daily humidity between January 1, 1973 and December 31, 1992, respectively. CPRI is the arithmetic mean of these four sub-indices. The original daily data of meteorological stations is sourced from NOAA (National Oceanic and Atmospheric Administration).
DOI: 10.17632/75m68dxd83
title: Supplementary Information for 'An updated phylogeny of the Alphaproteobacteria reveals that the parasitic Rickettsiales and Holosporales have independent origins' by Muñoz-Gómez, S.A. et al., (2019)

description: Datasets, trees and models for main and supplementary figures in 'An updated phylogeny of the Alphaproteobacteria reveals that the parasitic Rickettsiales and Holosporales have independent origins' by Muñoz-Gómez, S.A. et al., (2019).
DOI: 10.17632/8hxc7hr7m4
title: Data for: Targeted species assemblages exhibit uniform behavioral responses to protection
DOI: 10.17632/9yf88mmf9d
title: Fast computer evaluation of radiative properties of hydrogenic systems

description: Abstract Three subroutines are described for the very fast calculation of bound-bound, bound-free, and free-free cross-sections for nonrelativistic hydrogenic systems of arbitrary nuclear charge and reduced mass. The first two are essentially exact, being based on recursion relations which are known to be stable. The third evaluates the thermally-averaged free-free Gaunt factor by means of a two-dimensional Chebyshev expansion calculated by numerical evaluation of the cross-sections expressed as hyper... Title of program: RADZ1 Catalogue Id: ABZS_v1_0 Nature of problem Although the cross sections for the absorption and emission of radiation by hydrogenic systems are known exactly in the nonrelativistic approximation, the analytic expressions are not easy to evaluate, especially for large values of the principal quantum number. However, for bound-bound and bound-free transitions, recursion techniques have proved to be accurate and stable for values of the principal quantum number as large as 500. For free-free transitions, recursion techniques are not applicabl ... Versions of this program held in the CPC repository in Mendeley Data ABZS_v1_0; RADZ1; 10.1016/0010-4655(91)90013-B This program has been imported from the CPC Program Library held at Queen's University Belfast (1969-2018)
DOI: 10.17632/y94jyms83b
title: SZ-CLAY-10-7964

description: SZ-CLAY-10-7964 contains measurement data for various physical and mechanical parameters. The data includes parameters such as cohesion, friction angle, and plastic limit, obtained through different testing methods, such as consolidated quick direct shear tests. It covers measurement results from various regions and projects, providing detailed information on soil characteristics and their variations. This database is of significant value in geotechnical engineering, soil mechanics research, and design, supporting the analysis and prediction of soil behavior.
DOI: 10.17632/b87xzmzm2z
title: PWDFT.jl: A Julia package for electronic structure calculation using density functional theory and plane wave basis

description: We describe the implementation of PWDFT.jl, a package for electronic structure calculations written in Julia programming language using plane wave basis set and pseudopotentials. In this package, a typical Kohn–Sham density functional theory (KSDFT) is divided into three steps: initializing the molecular or crystalline structure, constructing the Kohn–Sham Hamiltonian, and solving the Kohn–Sham problem using self-consistent field (SCF) calculation. To facilitate various tasks involved in these steps, we provide several custom data types which are transparent and easy to be modified. Basic operations such as wave function orthogonalization, action of kinetic and potential operators to wave functions and iterative diagonalization of Hamiltonian have been implemented in pure Julia. Several algorithms to solve the Kohn–Sham problems such as self-consistent field and direct energy minimization have also been implemented in PWDFT.jl. To assess the validity of our implementation, we present the results of total energy calculations against the well-established ABINIT package. We also show how one can use PWDFT.jl to write a simple self-consistent field implementation.
DOI: 10.6084/m9.figshare.27191190.v1
title: Three sea buckthorn genome circular diagrams files

description: Here contains the circular diagrams files of male <i>Hippophae gyantsensis</i>, female <i>Hippophae salicifolia</i> and male <i>Hippophae salicifolia</i>. Male <i>Hippophae salicifolia</i> included two sets of haplotype data, hap1 and hap2.
DOI: 10.17632/x2sf762mhj
title: Dataset for 'A Small Nimble In situ Fine-scale Flux method for measuring tree stem greenhouse gas emissions and processes (S.N.I.F.F)' - Ecosystems

description: This dataset support our methods publication recently accepted in Ecosystems Manuscript highlights • Stable isotope analysis suggests δ13C-CH4 oxidation and fractionation occurs during transport • Substantial fine-scale vertical and radial heterogeneity identified in tree stem CH4 emissions • Novel smartphone 3D photogrammetry can more accurately estimate the tree stem surface area compared to traditional methods • Fine-scale sampling method shows 86-89% of methane flux emanates from the lower 30cm of wetland forest tree stems Manuscript Abstract: Tree stem methane emissions are gaining increasing attention as an overlooked atmospheric source pathway. Existing methods for measuring tree stem greenhouse gas fluxes and isotopes may provide robust integrated emission estimates, but due to their coarse resolution, the capacity to derive insights into fine-scale dynamics of tree stem emissions are limited. We demonstrate and field-test an alternative method that is Small, Nimble, In situ and allows for Fine-scale Flux (‘SNIFF’) measurements, on complex and contrasting stem surfaces. It is light weight and therefore suitable to remote field locations enabling real time data observations allowing for field-based data driven sampling regimes. This method facilitated novel results capturing fine-scale vertical and radial methane flux measurements (5cm increments) and revealed: (1) 86-89% of methane emissions emanated from the lower 30cm of sampled wetland tree species; (2) uncovered clear vertical and horizontal trends in δ13C-CH4 possibly due to fractionation associated with oxidation and mass-dependant fractionation during diffusive transport; and (3) demonstrated how substantial radial heterogeneity can occur. We also compared a variety of upscaling approaches to estimate methane flux per tree when using this method, including novel smartphone 3D photogrammetry, that resulted in a substantially higher stem surface area estimation (&gt;16 to 36%) than traditional empirical methods. Utilising small chambers with high radial and vertical resolution capabilities may therefore facilitate future assessments into the drivers, pathways, oxidation sinks and magnitude of various tree stem greenhouse gas emissions, and compliment previous broad-scale sampling techniques.
DOI: 10.17632/xhgdsgvpw7
title: Processed data_Processing and microstructural characterization of metallic powders produced from chips of AA2024 alloy

description: Processed data for AA2024 powder alloy.
DOI: 10.6084/m9.figshare.c.3605888_d1.v1
title: Additional file 1 of Parasail: SIMD C library for global, semi-global, and local pairwise sequence alignments

description: Parasail v1.0.0 source code. The source code of Parasail version 1.0.0 as a gzipped tar archive file. (GZ 1180 kb)
DOI: 10.17632/73kbfvbpfb
title: Data for ""Minus 1" and energy costs constants"

description: This is the research data for the article ""Minus 1" and energy costs constants: empirical evidence, theory and policy implications", published in the Structural Change and Economic Dynamics journal. The paper demonstrates an apparent long-term constancy of economy-wide energy expenditures relative to income. The dataset to the paper includes energy cost shares, energy prices, energy intensities and energy expenditures for selected countries.
DOI: 10.17632/bt63fx2ynf
title: Martin-Rojas et al. 2023

description: RINEX files 
Insights of active extension within a collisional orogen from GNSS (Central Betic Cordillera, S Spain)