cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.23612760
title: Perillyl alcohol modulates activation, permeability and integrity of human brain endothelial cells induced by Plasmodium falciparum

description: BACKGROUND Cerebral malaria (CM) is a severe immunovasculopathy caused for Plasmodium falciparum infection, which is characterised by the sequestration of parasitised red blood cells (pRBCs) in brain microvessels. Previous studies have shown that some terpenes, such as perillyl alcohol (POH), exhibit a marked efficacy in preventing cerebrovascular inflammation, breakdown of the brain-blood barrier (BBB) and brain leucocyte accumulation in experimental CM models. OBJECTIVE To analyse the effects of POH on the endothelium using human brain endothelial cell (HBEC) monolayers co-cultured with pRBCs. METHODOLOGY The loss of tight junction proteins (TJPs) and features of endothelial activation, such as ICAM-1 and VCAM-1 expression were evaluated by quantitative immunofluorescence. Microvesicle (MV) release by HBEC upon stimulation by P. falciparum was evaluated by flow cytometry. Finally, the capacity of POH to revert P. falciparum-induced HBEC monolayer permeability was examined by monitoring trans-endothelial electrical resistance (TEER). FINDINGS POH significantly prevented pRBCs-induced endothelial adhesion molecule (ICAM-1, VCAM-1) upregulation and MV release by HBEC, improved their trans-endothelial resistance, and restored their distribution of TJPs such as VE-cadherin, Occludin, and JAM-A. CONCLUSIONS POH is a potent monoterpene that is efficient in preventing P. falciparum-pRBCs-induced changes in HBEC, namely their activation, increased permeability and alterations of integrity, all parameters of relevance to CM pathogenesis.
DOI: 10.6084/m9.figshare.23612760.v1
title: Perillyl alcohol modulates activation, permeability and integrity of human brain endothelial cells induced by Plasmodium falciparum

description: BACKGROUND Cerebral malaria (CM) is a severe immunovasculopathy caused for Plasmodium falciparum infection, which is characterised by the sequestration of parasitised red blood cells (pRBCs) in brain microvessels. Previous studies have shown that some terpenes, such as perillyl alcohol (POH), exhibit a marked efficacy in preventing cerebrovascular inflammation, breakdown of the brain-blood barrier (BBB) and brain leucocyte accumulation in experimental CM models. OBJECTIVE To analyse the effects of POH on the endothelium using human brain endothelial cell (HBEC) monolayers co-cultured with pRBCs. METHODOLOGY The loss of tight junction proteins (TJPs) and features of endothelial activation, such as ICAM-1 and VCAM-1 expression were evaluated by quantitative immunofluorescence. Microvesicle (MV) release by HBEC upon stimulation by P. falciparum was evaluated by flow cytometry. Finally, the capacity of POH to revert P. falciparum-induced HBEC monolayer permeability was examined by monitoring trans-endothelial electrical resistance (TEER). FINDINGS POH significantly prevented pRBCs-induced endothelial adhesion molecule (ICAM-1, VCAM-1) upregulation and MV release by HBEC, improved their trans-endothelial resistance, and restored their distribution of TJPs such as VE-cadherin, Occludin, and JAM-A. CONCLUSIONS POH is a potent monoterpene that is efficient in preventing P. falciparum-pRBCs-induced changes in HBEC, namely their activation, increased permeability and alterations of integrity, all parameters of relevance to CM pathogenesis.
DOI: 10.6084/m9.figshare.21601220
title: Heritagization and gentrification: cause and consequence? The Marais district, in Paris

description: ABSTRACT The Marais district, in Paris, was one of the first to be recognized as a secteur sauvegardé, a designation given to an urban area of heritage value especially protected by French legislation from 1962 onwards. From that point onwards, the criticisms to the changes undertaken by the district mounted and, in the international scene, the Marais is often taken as an example of a heritagization process that led to the gentrification of the place. Thus, this article discusses the binomial heritagization/gentrification from the Marais case, presenting the process of neighborhood preservation in the context of the Malraux law, in 1962; the evolution of the urban heritage preservation concept and instruments throughout more than 50 years; and of the urban dynamics of Paris, a heritage, tourist, and “gentrified” capital. To this end, empirical data are used, showing, among others, the Marais situation within the demographic and socioeconomic changes experienced by the French capital. At the same time, a discussion on the gentrification concept and its generalized appropriation to characterize any process of socioeconomic transformation that implies the increase of the richest portion of a given population or, still, as a perverse consequence of any urban intervention is proposed.
DOI: 10.6084/m9.figshare.21601220.v1
title: Heritagization and gentrification: cause and consequence? The Marais district, in Paris

description: ABSTRACT The Marais district, in Paris, was one of the first to be recognized as a secteur sauvegardé, a designation given to an urban area of heritage value especially protected by French legislation from 1962 onwards. From that point onwards, the criticisms to the changes undertaken by the district mounted and, in the international scene, the Marais is often taken as an example of a heritagization process that led to the gentrification of the place. Thus, this article discusses the binomial heritagization/gentrification from the Marais case, presenting the process of neighborhood preservation in the context of the Malraux law, in 1962; the evolution of the urban heritage preservation concept and instruments throughout more than 50 years; and of the urban dynamics of Paris, a heritage, tourist, and “gentrified” capital. To this end, empirical data are used, showing, among others, the Marais situation within the demographic and socioeconomic changes experienced by the French capital. At the same time, a discussion on the gentrification concept and its generalized appropriation to characterize any process of socioeconomic transformation that implies the increase of the richest portion of a given population or, still, as a perverse consequence of any urban intervention is proposed.
DOI: 10.6084/m9.figshare.23612767
title: Lettuce production in hydroponic and fish-farming aquaponic under different channel slopes and nutrient solutions in the NFT system

description: ABSTRACT The slope of cultivation channels and types of nutrient solutions in hydroponics and aquaponics influence nutrient absorption and plant production. This research aimed to evaluate lettuce production under different channel slopes and nutrient solutions in hydroponic and aquaponic systems using the nutrient film technique (NFT). A randomized block design was used, with three replicates, in a 3 × 5 split-plot scheme, with three nutrient solutions (conventional hydroponic solution and two wastewaters from the tilapia fish diets, with 15 and 18% of crude protein) and five slopes (2, 4, 6, 8 and 10%) of cultivation channels (PVC tubes). The following variables were evaluated: fresh and dry mass of shoot and roots and the chemical elements of the solutions. In the tilapia feed, the nutrient solution with 18% of protein (wastewater) provides greater production and accumulation of nutrients (N and P) in the lettuce shoot. The slope of 8% on cultivation channels provides greater production of iceberg lettuce, cultivar Lucy Brown. The different slopes and nutrient solutions studied did not influence the potassium (K) accumulation in the lettuce shoot.
DOI: 10.6084/m9.figshare.23612767.v1
title: Lettuce production in hydroponic and fish-farming aquaponic under different channel slopes and nutrient solutions in the NFT system

description: ABSTRACT The slope of cultivation channels and types of nutrient solutions in hydroponics and aquaponics influence nutrient absorption and plant production. This research aimed to evaluate lettuce production under different channel slopes and nutrient solutions in hydroponic and aquaponic systems using the nutrient film technique (NFT). A randomized block design was used, with three replicates, in a 3 × 5 split-plot scheme, with three nutrient solutions (conventional hydroponic solution and two wastewaters from the tilapia fish diets, with 15 and 18% of crude protein) and five slopes (2, 4, 6, 8 and 10%) of cultivation channels (PVC tubes). The following variables were evaluated: fresh and dry mass of shoot and roots and the chemical elements of the solutions. In the tilapia feed, the nutrient solution with 18% of protein (wastewater) provides greater production and accumulation of nutrients (N and P) in the lettuce shoot. The slope of 8% on cultivation channels provides greater production of iceberg lettuce, cultivar Lucy Brown. The different slopes and nutrient solutions studied did not influence the potassium (K) accumulation in the lettuce shoot.
DOI: 10.6084/m9.figshare.23612770
title: Hydroponic coriander grown under nutritional solutions prepared with brackish water of different cation prevalence

description: ABSTRACT The use of brackish water for preparation of nutrient solutions has several impacts on crop performance, depending on the water concentration and cation prevalence. Therefore, this study was conducted to evaluate production and water relations of coriander grown on nutrient solutions prepared with brackish waters with different cationic natures under hydroponic conditions. A randomized block experimental design with four replicates was used, in a 4 × 3 factorial arrangement. The treatments consisted of four electrical conductivities of the nutrient solution (1.6, 3.2, 4.8, and 6.4 dS m-1) which were prepared in waters with different salts (NaCl, CaCl2.2H2O, and MgCl2.6H2O). Salinity negatively affected the production and water relations of coriander grown in hydroponic system; plants grown on nutritive solutions with predominance of Na+ had higher total dry weight and shoot dry weights, as well as higher stomatal conductance. The largest leaf area was found when using the nutrient solution with predominance of Mg2+.
DOI: 10.6084/m9.figshare.23612770.v1
title: Hydroponic coriander grown under nutritional solutions prepared with brackish water of different cation prevalence

description: ABSTRACT The use of brackish water for preparation of nutrient solutions has several impacts on crop performance, depending on the water concentration and cation prevalence. Therefore, this study was conducted to evaluate production and water relations of coriander grown on nutrient solutions prepared with brackish waters with different cationic natures under hydroponic conditions. A randomized block experimental design with four replicates was used, in a 4 × 3 factorial arrangement. The treatments consisted of four electrical conductivities of the nutrient solution (1.6, 3.2, 4.8, and 6.4 dS m-1) which were prepared in waters with different salts (NaCl, CaCl2.2H2O, and MgCl2.6H2O). Salinity negatively affected the production and water relations of coriander grown in hydroponic system; plants grown on nutritive solutions with predominance of Na+ had higher total dry weight and shoot dry weights, as well as higher stomatal conductance. The largest leaf area was found when using the nutrient solution with predominance of Mg2+.
DOI: 10.6084/m9.figshare.23612772
title: Changing Paradigms in the Initial Treatment of Ectopic Pregnancy at a University Hospital in Brazil

description: Abstract Objective To evaluate the use of different treatment options for ectopic pregnancy and the frequency of severe complications in a university hospital. Methods Observational study with women with ectopic pregnancy admitted at UNICAMP Womeńs Hospital, Brazil, between 01/01/2000 and 12/31/2017. The outcome variables were the type of treatment (first choice) and the presence of severe complications. Independent variables were clinical and sociodemographic data. Statistical analysis was carried out by the Cochran–Armitage test, chi-square test, Mann–Whitney test and multiple Cox regression. Results In total 673 women were included in the study. The mean age was 29.0 years (± 6.1) and the mean gestational age was 7.7 (± 2.5). The frequency of surgical treatment decreased significantly over time (z = -4.69; p &lt; 0.001). Conversely, there was a significant increase in the frequency of methotrexate treatment (z = 4.73; p &lt; 0.001). Seventy-one women (10.5%) developed some type of severe complication. In the final statistical model, the prevalence of severe complications was higher in women who were diagnosed with a ruptured ectopic pregnancy at admission (PR = 2.97; 95%CI: 1.61–5.46), did not present with vaginal bleeding (PR = 2.45; 95%CI: 1.41–4.25), had never undergone laparotomy/laparoscopy (PR = 6.69; 95%CI: 1.62–27.53), had a non-tubal ectopic pregnancy (PR = 4.61; 95%CI: 1.98–10.74), and do not smoke (PR = 2.41; 95%CI: 1.08–5.36). Conclusion there was a change in the first treatment option for cases of ectopic pregnancy in the hospital during the period of analysis. Factors inherent to a disease that is more difficult to treat are related to a higher frequency of severe complications.
DOI: 10.6084/m9.figshare.23612772.v1
title: Changing Paradigms in the Initial Treatment of Ectopic Pregnancy at a University Hospital in Brazil

description: Abstract Objective To evaluate the use of different treatment options for ectopic pregnancy and the frequency of severe complications in a university hospital. Methods Observational study with women with ectopic pregnancy admitted at UNICAMP Womeńs Hospital, Brazil, between 01/01/2000 and 12/31/2017. The outcome variables were the type of treatment (first choice) and the presence of severe complications. Independent variables were clinical and sociodemographic data. Statistical analysis was carried out by the Cochran–Armitage test, chi-square test, Mann–Whitney test and multiple Cox regression. Results In total 673 women were included in the study. The mean age was 29.0 years (± 6.1) and the mean gestational age was 7.7 (± 2.5). The frequency of surgical treatment decreased significantly over time (z = -4.69; p &lt; 0.001). Conversely, there was a significant increase in the frequency of methotrexate treatment (z = 4.73; p &lt; 0.001). Seventy-one women (10.5%) developed some type of severe complication. In the final statistical model, the prevalence of severe complications was higher in women who were diagnosed with a ruptured ectopic pregnancy at admission (PR = 2.97; 95%CI: 1.61–5.46), did not present with vaginal bleeding (PR = 2.45; 95%CI: 1.41–4.25), had never undergone laparotomy/laparoscopy (PR = 6.69; 95%CI: 1.62–27.53), had a non-tubal ectopic pregnancy (PR = 4.61; 95%CI: 1.98–10.74), and do not smoke (PR = 2.41; 95%CI: 1.08–5.36). Conclusion there was a change in the first treatment option for cases of ectopic pregnancy in the hospital during the period of analysis. Factors inherent to a disease that is more difficult to treat are related to a higher frequency of severe complications.
DOI: 10.6084/m9.figshare.23584965.v1
title: The diffusion of technologies in the agricultural environment in the Caatinga – a region with a semi-arid climate in Brazil

description: Abstract The use of technologies directly influences agribusiness productivity, being crucial for economically viable production in environments with adverse climate conditions, such as the Brazilian semiarid region. Thus, this article analyzes, through a systematic review, the technologies used in the agricultural environment in the Brazilian semiarid climate region, the Caatinga biome. The results initially present technologies for coexistence with the semiarid region or social techniques, with emphasis on methods of soil management, use of rainwater, and preparation of animal feed. About the technologies themselves, the evidence converges to the technological use directed to the viability of production, diversification, and harvest time, mainly for irrigated crops. Furthermore, genetic improvement also contributed to the propagation of resistant crops and the increase in the population of animals. At the same time, it was possible to identify the technological level of agricultural activity in the Caatinga, which, in most of the biome, has low use of technologies, characterized by subsistence activites, family labor, and monoculture, on the other hand, in local centers agricultural systems, there is the use of integrated systems and biologically-based agriculture.
DOI: 10.6084/m9.figshare.23584965
title: The diffusion of technologies in the agricultural environment in the Caatinga – a region with a semi-arid climate in Brazil

description: Abstract The use of technologies directly influences agribusiness productivity, being crucial for economically viable production in environments with adverse climate conditions, such as the Brazilian semiarid region. Thus, this article analyzes, through a systematic review, the technologies used in the agricultural environment in the Brazilian semiarid climate region, the Caatinga biome. The results initially present technologies for coexistence with the semiarid region or social techniques, with emphasis on methods of soil management, use of rainwater, and preparation of animal feed. About the technologies themselves, the evidence converges to the technological use directed to the viability of production, diversification, and harvest time, mainly for irrigated crops. Furthermore, genetic improvement also contributed to the propagation of resistant crops and the increase in the population of animals. At the same time, it was possible to identify the technological level of agricultural activity in the Caatinga, which, in most of the biome, has low use of technologies, characterized by subsistence activites, family labor, and monoculture, on the other hand, in local centers agricultural systems, there is the use of integrated systems and biologically-based agriculture.
DOI: 10.6084/m9.figshare.23612775
title: Intimate Relations: multispecie stories of manioc social life

description: Abstract Manioc (Manihot esculenta Crantz) is a way of life that gives us the opportunity to rethink agricultural production and thus provides a divergent understanding of the human domestication of plants. In the traditional literature about manioc, its evolution has been recognized as a process of domestication, the control of a biological species by humans or through “the paradigm of human exceptionalism.” In this paper we seek possible ways to tell another story about manioc and its human and non-human companions: a partial and modest testimony among many possibilities found between the biological and anthropological worlds. We argue that the domestication model is only a particular Western mode of telling the story and forming relations with maniocs. To contrast this we see the possibility of opening our minds to another story, to describe the human-manioc relation as an intimate relationship in which all elements are agents, and simultaneously objects of action. Maniocs are bodies-in-movement, growing and developing in the formation of multi-species landscapes. We understand this intimate relationship, as Donna Haraway explains, as a sympoietic story, a process of “becoming-with” that occurs in the flow of life.
DOI: 10.6084/m9.figshare.23612775.v1
title: Intimate Relations: multispecie stories of manioc social life

description: Abstract Manioc (Manihot esculenta Crantz) is a way of life that gives us the opportunity to rethink agricultural production and thus provides a divergent understanding of the human domestication of plants. In the traditional literature about manioc, its evolution has been recognized as a process of domestication, the control of a biological species by humans or through “the paradigm of human exceptionalism.” In this paper we seek possible ways to tell another story about manioc and its human and non-human companions: a partial and modest testimony among many possibilities found between the biological and anthropological worlds. We argue that the domestication model is only a particular Western mode of telling the story and forming relations with maniocs. To contrast this we see the possibility of opening our minds to another story, to describe the human-manioc relation as an intimate relationship in which all elements are agents, and simultaneously objects of action. Maniocs are bodies-in-movement, growing and developing in the formation of multi-species landscapes. We understand this intimate relationship, as Donna Haraway explains, as a sympoietic story, a process of “becoming-with” that occurs in the flow of life.
DOI: 10.6084/m9.figshare.23612776
title: Hospitalization and mortality from Parkinson’s Disease in Brazil from 2008 to 2020

description: ABSTRACT Parkinson’s Disease is irreversible and affects the central nervous system. As the disease mainly affects the elderly, attention and strategies for prevention and care for people who have the disease are essential, making it possible through the exposure of data that demonstrate the situation. The objective was to analyze the morbidity and mortality of the disease and the distribution by states and regions of Brazil from 2008 to 2020. This is an epidemiological, retrospective study, using the database of the Department of Informatics of the Unified Health System. An average of 875±166 hospitalizations per year was found, with a decrease in 2020. The most affected age group was between 60 and 79 years old, in men, but there was an increase in cases in younger people. Mortality found was 3333±759 per year, with statistically significant growth of the curve over time and higher rates in Rio Grande do Sul and Rio de Janeiro. It can be concluded that both the hospitalization rate and the mortality rate were predominant in the elderly and in males, with the South region having the highest mortality rate.
DOI: 10.6084/m9.figshare.23612776.v1
title: Hospitalization and mortality from Parkinson’s Disease in Brazil from 2008 to 2020

description: ABSTRACT Parkinson’s Disease is irreversible and affects the central nervous system. As the disease mainly affects the elderly, attention and strategies for prevention and care for people who have the disease are essential, making it possible through the exposure of data that demonstrate the situation. The objective was to analyze the morbidity and mortality of the disease and the distribution by states and regions of Brazil from 2008 to 2020. This is an epidemiological, retrospective study, using the database of the Department of Informatics of the Unified Health System. An average of 875±166 hospitalizations per year was found, with a decrease in 2020. The most affected age group was between 60 and 79 years old, in men, but there was an increase in cases in younger people. Mortality found was 3333±759 per year, with statistically significant growth of the curve over time and higher rates in Rio Grande do Sul and Rio de Janeiro. It can be concluded that both the hospitalization rate and the mortality rate were predominant in the elderly and in males, with the South region having the highest mortality rate.