cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.21946312
title: FAST-ED scale for prehospital triage of large vessel occlusion: results in the field

description: Abstract Background Acute ischemic stroke (AIS) is an extremely time-sensitive condition. The field triage of stroke patients should consider a careful balance between the best destination for the timely delivery of intravenous and/or endovascular reperfusion therapies. The Field Assessment Stroke Triage for Emergency Destination (FAST-ED) scale has been shown to have an accuracy comparable to that of the National Institutes of Health Stroke Scale (NIHSS). However, it has not been tested in the field. Objective To evaluate the accuracy of the FAST-ED scale in the detection of AIS due to large vessel occlusion (LVO) in the prehospital setting. Methods A cross-sectional study of consecutive prospective data collected from February 2017 to May 2019 in the city of Porto Alegre, state of Rio Grande do Sul, Southern Brazil, correlating the prehospital FAST-ED scale scores with the hospital diagnosis of LVO. Area under the curve (AUC), sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) were calculated. Results In total, 74 patients were included in the analysis. As compared with the diagnosis of LVO upon hospital discharge, the prehospital FAST-ED scale applied by paramedics had a sensitivity of 80%, a specificity of 47.7%, a PPV of 51.1%, an NPV of 77.8%, and an AUC of 0.68 (95% confidence interval [95%CI]: 0.55–0.80). Among the patients with a final diagnosis of AIS, the accuracy was higher, with an AUC of 0.75 (95%CI: 0.60–0.89), a sensitivity of 80%, a specificity of 60%, a PPV of 80%, and an NPV of 60%. Conclusions In the present study, the FAST-ED scale, which was applied by paramedics in the field, demonstrated moderate accuracy but high sensitivity and NPV, which are essential attributes for a triage scale. While larger studies are still needed, these findings further support the use of the FAST-ED in stroke triage.
DOI: 10.6084/m9.figshare.21946312.v1
title: FAST-ED scale for prehospital triage of large vessel occlusion: results in the field

description: Abstract Background Acute ischemic stroke (AIS) is an extremely time-sensitive condition. The field triage of stroke patients should consider a careful balance between the best destination for the timely delivery of intravenous and/or endovascular reperfusion therapies. The Field Assessment Stroke Triage for Emergency Destination (FAST-ED) scale has been shown to have an accuracy comparable to that of the National Institutes of Health Stroke Scale (NIHSS). However, it has not been tested in the field. Objective To evaluate the accuracy of the FAST-ED scale in the detection of AIS due to large vessel occlusion (LVO) in the prehospital setting. Methods A cross-sectional study of consecutive prospective data collected from February 2017 to May 2019 in the city of Porto Alegre, state of Rio Grande do Sul, Southern Brazil, correlating the prehospital FAST-ED scale scores with the hospital diagnosis of LVO. Area under the curve (AUC), sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) were calculated. Results In total, 74 patients were included in the analysis. As compared with the diagnosis of LVO upon hospital discharge, the prehospital FAST-ED scale applied by paramedics had a sensitivity of 80%, a specificity of 47.7%, a PPV of 51.1%, an NPV of 77.8%, and an AUC of 0.68 (95% confidence interval [95%CI]: 0.55–0.80). Among the patients with a final diagnosis of AIS, the accuracy was higher, with an AUC of 0.75 (95%CI: 0.60–0.89), a sensitivity of 80%, a specificity of 60%, a PPV of 80%, and an NPV of 60%. Conclusions In the present study, the FAST-ED scale, which was applied by paramedics in the field, demonstrated moderate accuracy but high sensitivity and NPV, which are essential attributes for a triage scale. While larger studies are still needed, these findings further support the use of the FAST-ED in stroke triage.
DOI: 10.6084/m9.figshare.22721855
title: Rita Levi-Montalcini: the neurologist who challenged fascism

description: Abstract Rita Levi-Montalcini was a researcher in the field of neuroscience, Italian and Jewish in origin, who discovered the nerve growth factor and rightfully earned the 1986 Nobel Prize in Physiology or Medicine, alongside her collaborator Stanley Cohen. She was persecuted by the fascist dictatorship of Benito Mussolini and experienced gender and religious discrimination throughout her entire life. Despite these obstacles, she carried out her activities with diligence and grace, becoming a role model in the field. This paper reviews the life and career of Rita Levi-Montalcini.
DOI: 10.6084/m9.figshare.22721855.v1
title: Rita Levi-Montalcini: the neurologist who challenged fascism

description: Abstract Rita Levi-Montalcini was a researcher in the field of neuroscience, Italian and Jewish in origin, who discovered the nerve growth factor and rightfully earned the 1986 Nobel Prize in Physiology or Medicine, alongside her collaborator Stanley Cohen. She was persecuted by the fascist dictatorship of Benito Mussolini and experienced gender and religious discrimination throughout her entire life. Despite these obstacles, she carried out her activities with diligence and grace, becoming a role model in the field. This paper reviews the life and career of Rita Levi-Montalcini.
DOI: 10.6084/m9.figshare.22721860
title: Association between the level of functional independence and the subjective experience of pain in older adults after hip replacement

description: ABSTRACT Hip replacement (HR) is a surgery that replaces the injured joint with a prosthesis. The postoperative period can reduce functional independence and affect the subjective experience of pain in older adults. This study evaluated the association between the level of functional independence and the subjective experience of pain in older adults who underwent HR. This cross-sectional descriptive quantitative association study used the functional independence measure (FIM) to assess the level of functional independence and the visual analogue scale (VAS) to analyze the subjective experience of pain. Spearman’s correlation test was used to evaluate the association between FIM and VAS and simple linear regression to analyze the influence of one variable on another (p≤0.05). This study evaluated 48 older adults, with a mean age of 71.5±9 years, of which 37.5% (n=18) were men and 62.5% (n=30) were women. The mean VAS and FIM values were 3.5 (±1.6) and 107 (±17.82), respectively, and they had a significant and inverse association (p=0.006; r=−0.389; R2=0.142). This study showed an inversely proportional relationship between the subjective experience of pain and the level of functional independence in older patients who underwent HR. Therefore, health professionals should pay more attention to pain in these patients in order to optimize their functional recovery and increase their functional independence.
DOI: 10.6084/m9.figshare.22721860.v1
title: Association between the level of functional independence and the subjective experience of pain in older adults after hip replacement

description: ABSTRACT Hip replacement (HR) is a surgery that replaces the injured joint with a prosthesis. The postoperative period can reduce functional independence and affect the subjective experience of pain in older adults. This study evaluated the association between the level of functional independence and the subjective experience of pain in older adults who underwent HR. This cross-sectional descriptive quantitative association study used the functional independence measure (FIM) to assess the level of functional independence and the visual analogue scale (VAS) to analyze the subjective experience of pain. Spearman’s correlation test was used to evaluate the association between FIM and VAS and simple linear regression to analyze the influence of one variable on another (p≤0.05). This study evaluated 48 older adults, with a mean age of 71.5±9 years, of which 37.5% (n=18) were men and 62.5% (n=30) were women. The mean VAS and FIM values were 3.5 (±1.6) and 107 (±17.82), respectively, and they had a significant and inverse association (p=0.006; r=−0.389; R2=0.142). This study showed an inversely proportional relationship between the subjective experience of pain and the level of functional independence in older patients who underwent HR. Therefore, health professionals should pay more attention to pain in these patients in order to optimize their functional recovery and increase their functional independence.
DOI: 10.5517/ccdc.csd.cc2f35c3
title: CCDC 2237374: Experimental Crystal Structure Determination

description: Related Article: Xiaoqian Zhu, Tian Ke, Jingyi Zhou, Yifei Song, Qianqian Xu, Zhiguo Zhang, Zongbi Bao, Yiwen Yang, Qilong Ren, Qiwei Yang|2023|J.Am.Chem.Soc.|145|9254|doi:10.1021/jacs.3c01784
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2f275y
title: CCDC 2236469: Experimental Crystal Structure Determination

description: Related Article: Xiaoqian Zhu, Tian Ke, Jingyi Zhou, Yifei Song, Qianqian Xu, Zhiguo Zhang, Zongbi Bao, Yiwen Yang, Qilong Ren, Qiwei Yang|2023|J.Am.Chem.Soc.|145|9254|doi:10.1021/jacs.3c01784
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2fbqdx
title: CCDC 2244629: Experimental Crystal Structure Determination

description: Related Article: Sushovan Paladhi, Si Joon Park, In-Soo Hwang, Jin Hyun Park, Han Yong Bae, Amol P. Jadhav, Choong Eui Song|2023|Org.Lett.|25|2713|doi:10.1021/acs.orglett.3c00825
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2fbqfy
title: CCDC 2244630: Experimental Crystal Structure Determination

description: Related Article: Sushovan Paladhi, Si Joon Park, In-Soo Hwang, Jin Hyun Park, Han Yong Bae, Amol P. Jadhav, Choong Eui Song|2023|Org.Lett.|25|2713|doi:10.1021/acs.orglett.3c00825
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cctdt55
title: CCDC 757087: Experimental Crystal Structure Determination

description: Related Article: Najla Karâa, Ali Ben Ahmed, Besma Hamdi|2023|J.Solid State Chem.|322|123954|doi:10.1016/j.jssc.2023.123954
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.6084/m9.figshare.22721864
title: Anti-herpes activity of the total alkaloid fraction from the branches of Fusaea longifolia (Annonaceae)

description: ABSTRACT The herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) occur worldwide. Infections caused by these viruses have great public health importance due to the growing resistance to the first-choice drug, acyclovir, especially in immunosuppressed patients. Alkaloids derived from species of Annonaceae have been reported as antiviral agents against HSV and others viruses. Within this context, we evaluated the antiviral activity of the total alkaloid fraction (TAF) extracted from the branches of Fusaea longifolia (Aubl.) Saff. (Annonaceae), a species native to the Amazon region, against the HSV-1 and HSV-2 viruses. The antiviral activity was evaluated through the plate reduction assay and the mode of action was investigated by a set of other assays. The TAF was active against the HSV-2 strain 333 and against the HSV-1 strains KOS and 29R (acyclovir resistant), with selectivity index values (SI = 50% cytotoxic concentration/50% effective concentration) of 5, 4 and 3, respectively. In the preliminary study of the anti-HSV-2 mode of action, TAF showed viral inhibitory effects if added up to 12 h post-infection, had virucidal activity and did not present viral inhibition in pre-treatment. Our results showed that the TAF exhibited anti-HSV activity. Regarding HSV-2, TAF acted after the viral infection and had virucidal activity. A mass spectrometry analysis revealed the presence of nine alkaloids in the TAF that had previously been reported for Annonaceae, including liriodenine, lysicamine and isoboldine, which have been described as potential anti-HSV-1 agents.
DOI: 10.6084/m9.figshare.22721864.v1
title: Anti-herpes activity of the total alkaloid fraction from the branches of Fusaea longifolia (Annonaceae)

description: ABSTRACT The herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) occur worldwide. Infections caused by these viruses have great public health importance due to the growing resistance to the first-choice drug, acyclovir, especially in immunosuppressed patients. Alkaloids derived from species of Annonaceae have been reported as antiviral agents against HSV and others viruses. Within this context, we evaluated the antiviral activity of the total alkaloid fraction (TAF) extracted from the branches of Fusaea longifolia (Aubl.) Saff. (Annonaceae), a species native to the Amazon region, against the HSV-1 and HSV-2 viruses. The antiviral activity was evaluated through the plate reduction assay and the mode of action was investigated by a set of other assays. The TAF was active against the HSV-2 strain 333 and against the HSV-1 strains KOS and 29R (acyclovir resistant), with selectivity index values (SI = 50% cytotoxic concentration/50% effective concentration) of 5, 4 and 3, respectively. In the preliminary study of the anti-HSV-2 mode of action, TAF showed viral inhibitory effects if added up to 12 h post-infection, had virucidal activity and did not present viral inhibition in pre-treatment. Our results showed that the TAF exhibited anti-HSV activity. Regarding HSV-2, TAF acted after the viral infection and had virucidal activity. A mass spectrometry analysis revealed the presence of nine alkaloids in the TAF that had previously been reported for Annonaceae, including liriodenine, lysicamine and isoboldine, which have been described as potential anti-HSV-1 agents.
DOI: 10.6084/m9.figshare.22721867
title: Synthesis and characterization of porous titanium structures obtained by gel-casting and sintering for biomedical applications

description: ABSTRACT The proper handling of porous structures in biomedical applications has relevant importance to avoid bone resorption and to allow the correct bone ingrowth. This structure leads to the nucleation and growing of bone inside them, obtaining a correct bonding between implant and bone. Consequently, this work investigates a manufacturing process of porous titanium structures obtained by means of a powder metallurgy technique based on gel-casting and sintering. This technique allows us to control the size, shape and distribution of the pores aiming to obtain a metallic structure capable to be utilized for biomedical implants. Samples were prepared by mixing different weight fractions of titanium hydride powder and acrylic resin powder (analyzed mixes were composed of 3%, 6%, 9%, 12%, 15%, 18% and 21% weight fraction of acrylic resin). The results indicate that it is possible to get samples with adequate porous structure, and microstructures with different kind of porosities (11% to 91% pore fraction) and porous size (3 µm up to 195 µm) in a wide range of values. This process allows to choose the appropriate pore characteristics for a certain application.
DOI: 10.6084/m9.figshare.22721867.v1
title: Synthesis and characterization of porous titanium structures obtained by gel-casting and sintering for biomedical applications

description: ABSTRACT The proper handling of porous structures in biomedical applications has relevant importance to avoid bone resorption and to allow the correct bone ingrowth. This structure leads to the nucleation and growing of bone inside them, obtaining a correct bonding between implant and bone. Consequently, this work investigates a manufacturing process of porous titanium structures obtained by means of a powder metallurgy technique based on gel-casting and sintering. This technique allows us to control the size, shape and distribution of the pores aiming to obtain a metallic structure capable to be utilized for biomedical implants. Samples were prepared by mixing different weight fractions of titanium hydride powder and acrylic resin powder (analyzed mixes were composed of 3%, 6%, 9%, 12%, 15%, 18% and 21% weight fraction of acrylic resin). The results indicate that it is possible to get samples with adequate porous structure, and microstructures with different kind of porosities (11% to 91% pore fraction) and porous size (3 µm up to 195 µm) in a wide range of values. This process allows to choose the appropriate pore characteristics for a certain application.
DOI: 10.6084/m9.figshare.21601066
title: Neuromuscular diseases and social distance resulting from the COVID-19 pandemic

description: Abstract Background Coronavirus 2 severe acute respiratory syndrome (SARS-CoV-2), generically called COVID-2019, classified as a pandemic by the World Health Organization, has made health practices around the world face unique challenges. Since then, physical distancing and measures such as confinement have been adopted by different governments to control human-to-human transmission. This distance affected the treatment of individuals with progressive diseases such as neuromuscular diseases (NMDs). Objective To identify how patients with NMDs performed the therapeutic routine during social distancing and confinement resulting from the COVID-19 pandemic. Methods Application of a questionnaire prepared in the Google forms application, whose link for access and participation was sent by email or WhatssApp for family members and/or individuals with DNMs to respond. The questionnaire consisted of multiple-choice questions, divided into the following sections: personal data, treatments performed before and during the pandemic, activities performed during confinement, and characterization of motor function in activities of daily living comprising the period between September and October 2020. Results We observed a significant reduction in medical appointments for patients with NMDs. On the other hand, the results showed that most patients underwent motor and/or respiratory physiotherapy in person or by telemonitoring. The study participants reported spending more time playing indoors, and all pointed out motor changes during social distancing. Conclusion There were changes in the therapeutic routine of patients with NMDs during the period of social distancing due to COVID-19.
DOI: 10.6084/m9.figshare.21601066.v1
title: Neuromuscular diseases and social distance resulting from the COVID-19 pandemic

description: Abstract Background Coronavirus 2 severe acute respiratory syndrome (SARS-CoV-2), generically called COVID-2019, classified as a pandemic by the World Health Organization, has made health practices around the world face unique challenges. Since then, physical distancing and measures such as confinement have been adopted by different governments to control human-to-human transmission. This distance affected the treatment of individuals with progressive diseases such as neuromuscular diseases (NMDs). Objective To identify how patients with NMDs performed the therapeutic routine during social distancing and confinement resulting from the COVID-19 pandemic. Methods Application of a questionnaire prepared in the Google forms application, whose link for access and participation was sent by email or WhatssApp for family members and/or individuals with DNMs to respond. The questionnaire consisted of multiple-choice questions, divided into the following sections: personal data, treatments performed before and during the pandemic, activities performed during confinement, and characterization of motor function in activities of daily living comprising the period between September and October 2020. Results We observed a significant reduction in medical appointments for patients with NMDs. On the other hand, the results showed that most patients underwent motor and/or respiratory physiotherapy in person or by telemonitoring. The study participants reported spending more time playing indoors, and all pointed out motor changes during social distancing. Conclusion There were changes in the therapeutic routine of patients with NMDs during the period of social distancing due to COVID-19.
DOI: 10.6084/m9.figshare.22721872
title: Validation of surgical care quality indicators in the Brazilian Unified Health System

description: ABSTRACT OBJECTIVE To validate a set of indicators for monitoring the quality of surgical procedures in the Brazilian Unified Health System (SUS). METHODS Validation study developed in 5 stages: 1) literature review; 2) prioritization of indicators; 3) content validation of indicators by RAND/UCLA consensus method; 4) pilot study for reliability analysis; and 5) development of instruction for tabulation of outcome indicators for monitoring via official information systems. RESULTS From the literature review, 217 indicators of surgical quality were identified. The excluded indicators were: those based on scientific evidence lower than 1A, similar, specific, which corresponded to sentinel events; and those that did not apply to the SUS context. Twenty-six indicators with a high level of scientific evidence were submitted to expert consensus. Twenty-two indicators were validated, of which 14 process indicators and 8 outcome indicators with content validation index ≥80%. Of the validated process indicators, 6 were considered substantially reliable (Kappa coefficient between 0.6 and 0.8; p &lt; 0.05) and 2 had almost perfect reliability (Kappa coefficient &gt; 0.8, p &lt; 0.05), when the inter-rater agreement was analyzed. One could measure and establish tabulation mechanism for TabWin for 7 outcome indicators. CONCLUSION The study contributes to the development of a set of potentially effective surgical indicators for monitoring the quality of care and patient safety in SUS hospital services.