cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.8988131
title: Physical disabilities due to leprosy in Alagoas State, Northeast Brazil: a temporal and spatial modeling

description: Abstract INTRODUCTION: Monitoring disability trends is required to evaluate leprosy elimination. We assessed the trends in disability indicators and its association with space in Alagoas, Brazil. METHODS: We conducted an ecological study in all leprosy cases from 2006 to 2016. Disability indicators were analyzed using the joinpoint regression model. RESULTS: The proportion of new cases with grade 2 disability at diagnosis ranged from 4.7% to 11.9% (annual percent change, 1.4; P= 0.7), while at discharge, it ranged from 0.0% to 12.3% (annual percent change, -21.8; P= 0.2). CONCLUSIONS: Disability indicators had a stable trend over the study period.
DOI: 10.6084/m9.figshare.8988134
title: The Bridge Occlusion Balloon for Venous Angioplasty in Superior Vena Cava Occlusion

description: Abstract The Bridge Occlusion Balloon is a compliant balloon, specifically designed for temporary Superior vena cava occlusion in case of Superior Vena Cava laceration during lead extraction procedures. We here report the first case, using Bridge Occlusion Ballon for a venous angioplasty in a patient with dysfunctional pacemaker leads and symptomatic Superior Vena Cava occlusion. After successful lead extraction, venography was showing a narrow venous canal. Therefore, venous angioplasty using the Bridge balloon was performed. Especially for high-risk lead extraction cases in patients with Superior Vena Cava stenosis, the Bridge Occlusion Ballon might be used as a combination of a safety-net in case of Superior Vena Cava perforation and for Superior Vena Cava angioplasty.
DOI: 10.6084/m9.figshare.8988137.v1
title: First Two Brazilian Cases: Correction of Ascending Aortic Aneurysm and Aortic Valve Stenosis with Sutureless/Rapid Deployment Aortic Prosthesis

description: Abstract Ascending aortic aneurysm is usually associated with aortic valve diseases, especially aortic stenosis. The standard technique involves the substitution of the dilated aortic segment with a Dacron tube and replacement of the aortic valve with a regular prosthesis. The correction of ascending aortic aneurysm with aortic valve replacement using the new sutureless and rapid deployment prosthesis was performed by a minimally invasive approach and for the first time in a Brazilian Center.
DOI: 10.6084/m9.figshare.8988131.v1
title: Physical disabilities due to leprosy in Alagoas State, Northeast Brazil: a temporal and spatial modeling

description: Abstract INTRODUCTION: Monitoring disability trends is required to evaluate leprosy elimination. We assessed the trends in disability indicators and its association with space in Alagoas, Brazil. METHODS: We conducted an ecological study in all leprosy cases from 2006 to 2016. Disability indicators were analyzed using the joinpoint regression model. RESULTS: The proportion of new cases with grade 2 disability at diagnosis ranged from 4.7% to 11.9% (annual percent change, 1.4; P= 0.7), while at discharge, it ranged from 0.0% to 12.3% (annual percent change, -21.8; P= 0.2). CONCLUSIONS: Disability indicators had a stable trend over the study period.
DOI: 10.6084/m9.figshare.8988134.v1
title: The Bridge Occlusion Balloon for Venous Angioplasty in Superior Vena Cava Occlusion

description: Abstract The Bridge Occlusion Balloon is a compliant balloon, specifically designed for temporary Superior vena cava occlusion in case of Superior Vena Cava laceration during lead extraction procedures. We here report the first case, using Bridge Occlusion Ballon for a venous angioplasty in a patient with dysfunctional pacemaker leads and symptomatic Superior Vena Cava occlusion. After successful lead extraction, venography was showing a narrow venous canal. Therefore, venous angioplasty using the Bridge balloon was performed. Especially for high-risk lead extraction cases in patients with Superior Vena Cava stenosis, the Bridge Occlusion Ballon might be used as a combination of a safety-net in case of Superior Vena Cava perforation and for Superior Vena Cava angioplasty.
DOI: 10.6084/m9.figshare.8988122
title: Attributable fraction of congenital syphilis due to the lack of prenatal care

description: Abstract INTRODUCTION: Although congenital syphilis is preventable, its incidence has increased in Brazil. METHODS: In this ecological study, a Bayesian spatio-temporal model was used to estimate the attributable fraction of congenital syphilis cases due to the lack of prenatal care recorded between 2010 and 2015 in the state of São Paulo, Southeast Brazil. RESULTS: For the year 2016, it was estimated that between 79.4% and 95.3% of the congenital syphilis cases among women who did not have prenatal care could have been prevented. CONCLUSIONS: A significant proportion of congenital syphilis cases can be prevented if prenatal care coverage is expanded.
DOI: 10.6084/m9.figshare.8988125
title: Cyclic pamidronate treatment for osteogenesis imperfecta: Report from a Brazilian reference center

description: Abstract Treatment of moderate and severe forms of osteogenesis imperfecta (OI) with cyclic pamidronate at the Reference Center for OI Treatment in Southern Brazil was studied. A retrospective cohort study was conducted from 2002 to 2012. Data were obtained during inpatient (drug infusion) and outpatient care. Clinical data, including the presence of blue sclerae, dentinogenesis imperfecta, history and site of the fractures, biochemical data, including calcium, phosphorus, and alkaline phosphatase levels, were systematically collected. Bone mineral density (BMD) was measured using dual energy X-ray absorptiometry (DXA). Forty-five patients (26 females) were included in the study, and the age of the patients at the time of diagnosis ranged from 1 to 144 months, with a median age (p25-p75) of 38 (5-96) months. Most cases presented OI-4 (51.1%), and the median age of the patients at the start of treatment was 3.3 years (25-75 percentiles: 0.5 - 8.7 years). Twenty-four patients (54.5%) had some adverse events or intercurrences during treatment, and the treatment compliance mean was 92.3% (± 10.7). The treatment with intravenous pamidronate has shown to be safe, well-tolerated, and effective in regard to the improvement of BMD and the reduction of the number of fractures in children and adolescents with OI.
DOI: 10.6084/m9.figshare.8988125.v1
title: Cyclic pamidronate treatment for osteogenesis imperfecta: Report from a Brazilian reference center

description: Abstract Treatment of moderate and severe forms of osteogenesis imperfecta (OI) with cyclic pamidronate at the Reference Center for OI Treatment in Southern Brazil was studied. A retrospective cohort study was conducted from 2002 to 2012. Data were obtained during inpatient (drug infusion) and outpatient care. Clinical data, including the presence of blue sclerae, dentinogenesis imperfecta, history and site of the fractures, biochemical data, including calcium, phosphorus, and alkaline phosphatase levels, were systematically collected. Bone mineral density (BMD) was measured using dual energy X-ray absorptiometry (DXA). Forty-five patients (26 females) were included in the study, and the age of the patients at the time of diagnosis ranged from 1 to 144 months, with a median age (p25-p75) of 38 (5-96) months. Most cases presented OI-4 (51.1%), and the median age of the patients at the start of treatment was 3.3 years (25-75 percentiles: 0.5 - 8.7 years). Twenty-four patients (54.5%) had some adverse events or intercurrences during treatment, and the treatment compliance mean was 92.3% (± 10.7). The treatment with intravenous pamidronate has shown to be safe, well-tolerated, and effective in regard to the improvement of BMD and the reduction of the number of fractures in children and adolescents with OI.
DOI: 10.6084/m9.figshare.8988122.v1
title: Attributable fraction of congenital syphilis due to the lack of prenatal care

description: Abstract INTRODUCTION: Although congenital syphilis is preventable, its incidence has increased in Brazil. METHODS: In this ecological study, a Bayesian spatio-temporal model was used to estimate the attributable fraction of congenital syphilis cases due to the lack of prenatal care recorded between 2010 and 2015 in the state of São Paulo, Southeast Brazil. RESULTS: For the year 2016, it was estimated that between 79.4% and 95.3% of the congenital syphilis cases among women who did not have prenatal care could have been prevented. CONCLUSIONS: A significant proportion of congenital syphilis cases can be prevented if prenatal care coverage is expanded.
DOI: 10.6084/m9.figshare.8988107
title: Hiring and retaining physicians to work in primary health care in the state of Bahia

description: Abstract This article analyzes the strategies of work management adopted at the Fundação Estatal Saúde da Família (State Health Family Foundation) (FESF-SUS), which was created to hire and allocate physicians in the Brazilian state of Bahia. The research aims to contribute to the debate about the difficulties of hiring and retaining physicians to work in the public policy promoting family health “Estratégia Saúde da Família” (ESF). The research consisted of a case study adopting several methodological strategies, with emphasis on documentary analysis. The findings show that one solution to hire and retain physicians is the creation of an inter-municipal career. The proposed work management of the Foundation included aspects such as variable compensation, worker mobility between municipalities, and factors associated with the provision of physicians to work in public health. The complexity of this proposal is faced with the lack of experience in operating this form of work management, as well as with the structural and institutional issues that historically marked the work management in the municipalities.
DOI: 10.6084/m9.figshare.8988101
title: Effects of Gas Nitriding on Fatigue and Crack Initiation of Ti6Al4V produced by Selective Laser Melting

description: Selective laser melting (SLM) is an additive manufacturing technique which permits fabrication of three dimensional parts by selectively melting consecutive layers of metallic powder. This allows the production of parts with high geometrical complexity. Titanium alloy Ti-6Al-4V (Ti64) is widely used in industry due to its high strength-to-mass ratio, corrosion resistance and biocompatibility. SLM increases the application range of Ti64 because of its flexibility for prototyping any part and its low material waste. Nitriding is a diffusion-based thermo-chemical treatment for interstitial hardening of the surface of Ti64 alloy products. This study characterized the fatigue behaviour of SLM-produced Ti64 nitrided and annealed bars in as-built and machined surface conditions. The surface of the SLM-produced Ti64 parts after gas nitriding showed high values of micro-hardness up to 550 HV just below the surface. Fatigue testing was performed to assess the materials fatigue strength and fractographic imaging was used to examine fracture surface and nitride layer characteristics. Nitriding was found to reduce the fatigue strength of the samples to a similar level irrespective of being in the as-built or machined condition. The effect of nitriding on crack initiation and growth at various stress levels under fatigue loading was investigated.
DOI: 10.6084/m9.figshare.8988107.v1
title: Hiring and retaining physicians to work in primary health care in the state of Bahia

description: Abstract This article analyzes the strategies of work management adopted at the Fundação Estatal Saúde da Família (State Health Family Foundation) (FESF-SUS), which was created to hire and allocate physicians in the Brazilian state of Bahia. The research aims to contribute to the debate about the difficulties of hiring and retaining physicians to work in the public policy promoting family health “Estratégia Saúde da Família” (ESF). The research consisted of a case study adopting several methodological strategies, with emphasis on documentary analysis. The findings show that one solution to hire and retain physicians is the creation of an inter-municipal career. The proposed work management of the Foundation included aspects such as variable compensation, worker mobility between municipalities, and factors associated with the provision of physicians to work in public health. The complexity of this proposal is faced with the lack of experience in operating this form of work management, as well as with the structural and institutional issues that historically marked the work management in the municipalities.
DOI: 10.6084/m9.figshare.8988098
title: Decomposition Rate, pH, and Enamel Color Alteration of At-Home and In-Office Bleaching Agents

description: Abstract This study evaluated the decomposition rate (DR), pH, enamel color alteration (DE) and whiteness index (DWI) promoted by at-home and in-office bleaching. Enamel surface was submitted to (n=10): at-home (10%, 15%, 20% carbamide peroxide - CP, 6% hydrogen peroxide -HP) and three 35% HP agents with light irradiation (LED, laser, and halogen) or no treatment (control). The DR and pH of agents were measured after 0, 2, 4, 6 and 8 h (at-home) or after 5, 15, 20, 30 and 40 min (in-office). Color parameters (L*, a*, b*, DE, DWI) were determined at baseline and after bleaching. DR, pH, L*, a*, b* data were analyzed by one-way (at-home) or two-way (in-office) repeated measures ANOVA and Tukey test. DE and DWI, by one-way (at-home) or two-way (in-office) ANOVA and Tukey test. DR of at-home agents was similar after 6 and 8 h (p&gt;0.05), with pH close to neutral (6.5 to 6.9, CP) or acid 5.9 (6% HP). From 4 to 8 h, DE was higher for 15% and 20% CP compared with 10% CP (p&lt;0.05). After 40 min, DR of 35% HP agents was similar and all exhibited significant DE in one application (p&lt;0.05), regardless light irradiation. DWI indicated whitening effect with no differences among groups (p&gt;0.05). One 35% HP showed alkaline pH, and the others, pH &lt; 5.5. At-home agents could be applied for 2 h (15%, 20% CP, 6% HP) and 4 h (10% CP) and the in-office agents, up to 40 min in one application, without light.
DOI: 10.6084/m9.figshare.8988092
title: The influence of allergic rhinoconjunctivitis on migraine disability in children

description: ABSTRACT Migraine is a common condition in the pediatric population and causes a significant impact on the quality of life. Atopic disorders are some of the migraine comorbidities. Objective We hypothesized that allergic rhinitis could aggravate migraine in the pediatric population. Methods This cross-sectional study consecutively evaluated 90 pediatric outpatients (46 children 6–12 years of age; 44 adolescents up to 18 years of age) who sought medical assistance because of migraine at a general neurology clinic in Passo Fundo, RS, Brazil. They, and their parents, were given three questionnaires, to evaluate the diagnosis of current allergic rhinitis, allergic rhinoconjunctivitis and seasonal allergic rhinitis, as well as the disability caused by headache (ISAAC - International Study of Asthma and Allergies in Childhood; CARATkids - Control of Allergic Rhinitis and Asthma Test for Children; PedMIDAS - Pediatric Migraine Disability Assessment). The study was approved by the local ethics committee. Results According to the ISAAC questionnaire, children with current allergic rhinoconjunctivitis in the last year showed higher scores on the PedMIDAS than those patients without atopy (median and interquartile range 26 [10–58] vs. 5 [1–13], p = 0.008). A significant positive correlation of CARATkids scores with PedMIDAS scores was found (p = 0.007, rho = 0.39). After including other putative predictors of migraine disability (age, body mass index, time since onset of migraine) in a multiple regression analysis, only the scores on the CARATkids remained a significant independent variable correlated with PedMIDAS scores (p = 0.001; R = 0.55; R2 = 0.30). Conclusions Current allergic rhinoconjunctivitis is related to enhanced disability caused by headache in childhood migraine.
DOI: 10.6084/m9.figshare.8988095
title: Growth of tomato seedlings in substrates containing a nanocomposite hydrogel with calcium montmorillonite (NC-MMt)

description: ABSTRACT The correct use of hydrogels in some situations can increase seedling survival rates, plant growth, and the water-retention capacity of the growing medium. A technique for the production of a nanocomposite hydrogel using calcium montmorillonite (NC-MMt) was recently developed. However, additional research is necessary in order to validate this innovative input, particularly for the production of vegetable crops seedlings. In this context, the main objective of the present study was to evaluate the growth and development of seedlings, tomato hybrid ‘BRS Nagai’, in substrates containing different amendments of hydrogel NC-MMt. The trial was conducted in a 3x3 factorial arranged in a complete randomized blocks design, with three replications. Three substrates (peat moss, pine bark, and coconut peat) corresponded to the first factor and three rates of the NC-MMt hydrogel (0%= R1, 1.5%= R2 and 2.0%= R3, on a w/w basis) corresponded to the second factor. Each plot was composed of 16 plants that were assessed after three weeks. Overall, peat moss-based and pine bark-based substrates resulted in higher values for most of the analyzed traits: plant emergency percentage, plant height, stem diameter, leaf area, plant height/shoot dry weight ratio, root dry weight, shoot dry weight/root dry weight ratio and the Dickinson Quality Index. Rates of NC-MMt hydrogel displayed significant responses only to root superficial area and root volume. NC-MMt hydrogel amendment (mainly 1.5%) combined with specific substrates (mainly peat moss-based substrate) was able to improve the growth of ‘BRS Nagai’ tomato seedlings, with no observed toxic effects.
DOI: 10.6084/m9.figshare.8988101.v1
title: Effects of Gas Nitriding on Fatigue and Crack Initiation of Ti6Al4V produced by Selective Laser Melting

description: Selective laser melting (SLM) is an additive manufacturing technique which permits fabrication of three dimensional parts by selectively melting consecutive layers of metallic powder. This allows the production of parts with high geometrical complexity. Titanium alloy Ti-6Al-4V (Ti64) is widely used in industry due to its high strength-to-mass ratio, corrosion resistance and biocompatibility. SLM increases the application range of Ti64 because of its flexibility for prototyping any part and its low material waste. Nitriding is a diffusion-based thermo-chemical treatment for interstitial hardening of the surface of Ti64 alloy products. This study characterized the fatigue behaviour of SLM-produced Ti64 nitrided and annealed bars in as-built and machined surface conditions. The surface of the SLM-produced Ti64 parts after gas nitriding showed high values of micro-hardness up to 550 HV just below the surface. Fatigue testing was performed to assess the materials fatigue strength and fractographic imaging was used to examine fracture surface and nitride layer characteristics. Nitriding was found to reduce the fatigue strength of the samples to a similar level irrespective of being in the as-built or machined condition. The effect of nitriding on crack initiation and growth at various stress levels under fatigue loading was investigated.
DOI: 10.6084/m9.figshare.8988098.v1
title: Decomposition Rate, pH, and Enamel Color Alteration of At-Home and In-Office Bleaching Agents

description: Abstract This study evaluated the decomposition rate (DR), pH, enamel color alteration (DE) and whiteness index (DWI) promoted by at-home and in-office bleaching. Enamel surface was submitted to (n=10): at-home (10%, 15%, 20% carbamide peroxide - CP, 6% hydrogen peroxide -HP) and three 35% HP agents with light irradiation (LED, laser, and halogen) or no treatment (control). The DR and pH of agents were measured after 0, 2, 4, 6 and 8 h (at-home) or after 5, 15, 20, 30 and 40 min (in-office). Color parameters (L*, a*, b*, DE, DWI) were determined at baseline and after bleaching. DR, pH, L*, a*, b* data were analyzed by one-way (at-home) or two-way (in-office) repeated measures ANOVA and Tukey test. DE and DWI, by one-way (at-home) or two-way (in-office) ANOVA and Tukey test. DR of at-home agents was similar after 6 and 8 h (p&gt;0.05), with pH close to neutral (6.5 to 6.9, CP) or acid 5.9 (6% HP). From 4 to 8 h, DE was higher for 15% and 20% CP compared with 10% CP (p&lt;0.05). After 40 min, DR of 35% HP agents was similar and all exhibited significant DE in one application (p&lt;0.05), regardless light irradiation. DWI indicated whitening effect with no differences among groups (p&gt;0.05). One 35% HP showed alkaline pH, and the others, pH &lt; 5.5. At-home agents could be applied for 2 h (15%, 20% CP, 6% HP) and 4 h (10% CP) and the in-office agents, up to 40 min in one application, without light.
DOI: 10.6084/m9.figshare.8988089
title: The effect of vortioxetine on penicillin-induced epileptiform activity in rats

description: ABSTRACT Vortioxetine is a multimodal antidepressant agent that modulates 5-HT receptors and inhibits the serotonin transporter. It is indicated especially in cases of major depressive disorder related to cognitive dysfunction. There are many studies investigating the effects of antidepressants on the seizure threshold and short-term epileptic activity. However, the effect of vortioxetine on epileptic seizures is not exactly known. Our aim was to investigate the effects of vortioxetine on penicillin-induced epileptiform activity. Twenty-seven Wistar rats were divided into three groups: sham-control group, positive control group (diazepam), and vortioxetine group. After a penicillin-induced epilepsy model was formed in each of the three groups of animals, 0.1 ml of saline was administered to the control group, 0.1 ml (10 mg/kg) vortioxetine was administered in the vortioxetine group, and 0.1 mL (5 mg/kg) of diazepam was administered in the positive control group, intraperitoneally. The epileptic activity records were obtained for 120 minutes after the onset of seizure. There was no significant difference in spike wave activity between the vortioxetine and diazepam groups, whereas this was significantly reduced in the vortioxetine group compared with the controls. The administration of vortioxetine at a dose of 10 mg/kg immediately after the seizure induction significantly decreased the spike frequencies of epileptiform activity compared with the control group. No significant difference was found between the vortioxetine and positive controls. This study showed that vortioxetine reduces the number of acutely-induced epileptic discharges. Vortioxetine may be an important alternative for epileptic patients with major depressive disorder-related cognitive dysfunction.