cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.7101506
title: Relationship between panic disorder and plasma neuropeptide-S level

description: Abstract Background: Panic disorder has long been associated with the changes in various neurotransmitters, such as Neuropeptide-S (NPS). Objective: In this study we aimed to determine whether there is a relationship between blood NPS levels and panic disorder. Methods: Twenty nine patients with panic disorder and thirty two healthy control subjects who were age and gender matched were enrolled to the study. Blood samples were taken from participants and plasma NPS levels were quantified by using an ELISA kit. Results: In the study group, median NPS blood level was 16.7 pg/mL and in the control group it was 32.5 pg/mL. There was a statistically significant difference (p = 0.021). Using receiver operating characteristics (ROC) curve, sensitivity and specificity of NPS blood level, for diagnosing panic disorder was calculated, and it was found 79.3% and 56.25% respectively (AUC:0.672, 95% CI: 0.540-0.787). Discussion: Malfunction at the NPS modulatory system in the cortical areas (which is causing excitations in brain areas, such as amygdala and hypothalamus) does not only increase anxiety symptoms and risk of panic disorder but also causes panic disorder patients to have lower plasma NPS levels than the control group. Therefore it can be argued that such malfunction can be treated with a systemic treatment. Baykan H et al. / Arch Clin Psychiatry. 2018;45(4):79-81
DOI: 10.6084/m9.figshare.7101503.v1
title: Towards a unified terminology for angiosperm reproductive systems

description: ABSTRACT Angiosperms display an enormous diversity of forms, functions and strategies when it comes to reproduction. This multiplicity has been translated into several terminological concepts and contexts, which have facilitated further research. On the other hand, the use of terms that address the reproduction of flowering plants has been shown to be inconsistent in the literature, complicating communication among specialists. Key terms, such as “reproductive system”, “mating system” and “sexual system”, among others, have been frequently cited as synonyms, and even used in different circumstances. This review proposes to establish a consistent nomenclatural classification in the field of angiosperms reproductive biology in order to facilitate communication among researchers. Specific terms related to angiosperm reproduction are conceptualized and distributed into five general systems: four related to sexual reproduction (sexual, floral, incompatibility and mating systems); and one related to asexual reproduction (apomictic systems). Our proposal is not to establish a natural classification, but rather to provide a general overview of the main concepts that were grouped here in an artificial and functional manner. Our aim is to advance the field of reproductive biology of angiosperms with consistent and well-defined applications of relevant terminologies.
DOI: 10.6084/m9.figshare.7101506.v1
title: Relationship between panic disorder and plasma neuropeptide-S level

description: Abstract Background: Panic disorder has long been associated with the changes in various neurotransmitters, such as Neuropeptide-S (NPS). Objective: In this study we aimed to determine whether there is a relationship between blood NPS levels and panic disorder. Methods: Twenty nine patients with panic disorder and thirty two healthy control subjects who were age and gender matched were enrolled to the study. Blood samples were taken from participants and plasma NPS levels were quantified by using an ELISA kit. Results: In the study group, median NPS blood level was 16.7 pg/mL and in the control group it was 32.5 pg/mL. There was a statistically significant difference (p = 0.021). Using receiver operating characteristics (ROC) curve, sensitivity and specificity of NPS blood level, for diagnosing panic disorder was calculated, and it was found 79.3% and 56.25% respectively (AUC:0.672, 95% CI: 0.540-0.787). Discussion: Malfunction at the NPS modulatory system in the cortical areas (which is causing excitations in brain areas, such as amygdala and hypothalamus) does not only increase anxiety symptoms and risk of panic disorder but also causes panic disorder patients to have lower plasma NPS levels than the control group. Therefore it can be argued that such malfunction can be treated with a systemic treatment. Baykan H et al. / Arch Clin Psychiatry. 2018;45(4):79-81
DOI: 10.6084/m9.figshare.7101494
title: Dynamic thiol/disulfide homeostasis in patients with age-related macular degeneration

description: ABSTRACT Purpose: We evaluated dynamic thiol/disulfide homeostasis (TDH), malondialdehyde (MDA) levels, and catalase (CAT) activity in patients with age-related macular degeneration (AMD). All analyzes were conducted on plasma samples. Methods: Thirty-two patients with AMD and 38 age-matched healthy controls were included. Native thiol, total thiol, and disulfide levels and TDH status were determined using a novel, automated assay. MDA levels and CAT activity were determined. Percentages were compared using the chi-squared test. The Student's t-test and Mann-Whitney U-test were used to compare quantitative variables. Results: Native thiol levels were significantly lower (p=0.004) in patients with AMD (272.02 ± 52.41 µmol/l) than in healthy individuals (307.82 ± 47.18 µmol/l), whereas disulfide levels were significantly higher (p&lt;0.001) in patients with AMD than in controls (21.64 ± 5.59 vs. 14.48 ± 5.37 µmol/L). Dynamic TDH was also significantly lower (p&lt;0.001) in patients with AMD than in controls (13.41 ± 4.3 vs. 25.41 ± 14.52 µmol/l). No significant differences were evident in total thiol or MDA levels. Mean CAT activity was significantly higher (p=0.043) in patients with AMD compared with controls (0.035 vs. 0.018 k/ml). Conclusions: The antioxidant/oxidant balance demonstrated by dynamic TDH is shifted to the oxidative side in patients with AMD.
DOI: 10.6084/m9.figshare.7101497
title: Assessment of eye drop instillation technique in glaucoma patients

description: ABSTRACT Purpose: To study the technique of eye drop instillation in glaucoma patients and identify independent factors that may influence their performance. Methods: In this cross-sectional study, 71 consecutive patients with glaucoma or ocular hypertension, self-administering topical anti-glaucoma medications for ≥6 months were evaluated. All patients instilled a tear substitute into the eye with the worst eyesight using the technique normally used at home. The following parameters were evaluated: age, number of years receiving treatment with ocular hypotensive eye drops, time spent to instill the first drop, number of drops instilled, correct location of the eye drops, contact of the bottle with the eye, closing of the eyelids or occlusion of the tear punctum, and asepsis of the hands. Results: The mean age of the patients was 66 ± 10.8 years, and patients were on ocular hypotensive drugs for 11.3 ± 7.3 (range, 2-35) years. Only 28% of the patients were able to correctly instill the eye drops (squeeze out 1 drop and instill it into the conjunctival sac without bottle tip contact). Touching the tip of the bottle to the globe or periocular tissue occurred in 62% of the patients. In 49% of the patients, the eye drops fell on the eyelids or cheek. Two or more drops were squeezed by 27% of the patients. Conclusions: The majority of glaucoma patients were unable to correctly instill eye drops. Age was an independent factor associated with eye drop instillation performance.
DOI: 10.6084/m9.figshare.7101488
title: Ophthalmic evaluation, treatment, and follow-up of two cases of incontinentia pigmenti

description: Incontinentia pigmenti (IP) is an X-linked dominant disorder affecting the skin, teeth, eyes, and central nervous system. Ocular changes are common and may lead to severe vision loss. We report on the ocular manifestations in two young girls with IP, with emphasis on the asymmetry of this condition in both eyes and associated retinal problems. The outcomes of laser treatment of the ischemic peripheral retina were good and resulted in stability of vision.
DOI: 10.6084/m9.figshare.7101491
title: Treatment of astigmatism during phacoemulsification

description: Purpose: To compare the effectiveness of limbal relaxing incisions (LRI) with that of toric intraocular lens (IOL) implantation for the treatment of astigmatism during phacoemulsification using nonvectorial (predictability, safety, and efficacy) and vectorial analyses. Methods: This longitudinal observational case series assessed 62 eyes of 31 consecutive cataract patients with preoperative corneal astigmatism of 0.75-2.50 diopters (D) in both eyes. Patients were randomly assigned to 2 groups: a toric IOL group, which received toric IOLs in both eyes, and an LRI group, which received spherical IOLs associated with LRI placement in both eyes. All patients were evaluated at 1, 3, and 6 months after surgery, when refractive astigmatism analysis was performed using both nonvectorial and Alpins vectorial methods. Outcomes were assessed within each group and compared between groups. Results: The proportion of eyes within ±0.50 D of the intended correction at 3 and 6 months after surgery was 75% and 71.88%, respectively, in the LRI group and 40% and 66.67%, respectively, in the toric IOL group. In the remaining period, the proportion was greater in the toric IOL group. The safety index showed no difference at any time point. The efficacy index at 1 and 3 months after surgery was significantly higher in the toric IOL group (0.43 and 0.44, respectively) than in the LRI group (0.31 and 0.36, respectively). At 6 months after surgery, the status of eyes in the LRI group was as follows: 53.13% were undercorrected, 43.74% achieved the intended correction, and 3.13% were overcorrected. In the toric IOL group, 16.76% eyes were undercorrected, 76.67% achieved the intended correction, and 6.67% were overcorrected. The success rates for astigmatic surgery, astigmatism reduction at the intended axis, and astigmatism corrected were 43%, 62%, and 64%, respectively, in the LRI group and 57%, 81%, and 94%, respectively, in the toric IOL group. Conclusions: Our results suggest that the use of toric IOLs may be advantageous over the use of LRIs for the treatment of astigmatism during phacoemulsification. Although such advantages seem subtle in nonvectorial analyses, they are highlighted in vectorial analyses.
DOI: 10.6084/m9.figshare.7101494.v1
title: Dynamic thiol/disulfide homeostasis in patients with age-related macular degeneration

description: ABSTRACT Purpose: We evaluated dynamic thiol/disulfide homeostasis (TDH), malondialdehyde (MDA) levels, and catalase (CAT) activity in patients with age-related macular degeneration (AMD). All analyzes were conducted on plasma samples. Methods: Thirty-two patients with AMD and 38 age-matched healthy controls were included. Native thiol, total thiol, and disulfide levels and TDH status were determined using a novel, automated assay. MDA levels and CAT activity were determined. Percentages were compared using the chi-squared test. The Student's t-test and Mann-Whitney U-test were used to compare quantitative variables. Results: Native thiol levels were significantly lower (p=0.004) in patients with AMD (272.02 ± 52.41 µmol/l) than in healthy individuals (307.82 ± 47.18 µmol/l), whereas disulfide levels were significantly higher (p&lt;0.001) in patients with AMD than in controls (21.64 ± 5.59 vs. 14.48 ± 5.37 µmol/L). Dynamic TDH was also significantly lower (p&lt;0.001) in patients with AMD than in controls (13.41 ± 4.3 vs. 25.41 ± 14.52 µmol/l). No significant differences were evident in total thiol or MDA levels. Mean CAT activity was significantly higher (p=0.043) in patients with AMD compared with controls (0.035 vs. 0.018 k/ml). Conclusions: The antioxidant/oxidant balance demonstrated by dynamic TDH is shifted to the oxidative side in patients with AMD.
DOI: 10.6084/m9.figshare.7101497.v1
title: Assessment of eye drop instillation technique in glaucoma patients

description: ABSTRACT Purpose: To study the technique of eye drop instillation in glaucoma patients and identify independent factors that may influence their performance. Methods: In this cross-sectional study, 71 consecutive patients with glaucoma or ocular hypertension, self-administering topical anti-glaucoma medications for ≥6 months were evaluated. All patients instilled a tear substitute into the eye with the worst eyesight using the technique normally used at home. The following parameters were evaluated: age, number of years receiving treatment with ocular hypotensive eye drops, time spent to instill the first drop, number of drops instilled, correct location of the eye drops, contact of the bottle with the eye, closing of the eyelids or occlusion of the tear punctum, and asepsis of the hands. Results: The mean age of the patients was 66 ± 10.8 years, and patients were on ocular hypotensive drugs for 11.3 ± 7.3 (range, 2-35) years. Only 28% of the patients were able to correctly instill the eye drops (squeeze out 1 drop and instill it into the conjunctival sac without bottle tip contact). Touching the tip of the bottle to the globe or periocular tissue occurred in 62% of the patients. In 49% of the patients, the eye drops fell on the eyelids or cheek. Two or more drops were squeezed by 27% of the patients. Conclusions: The majority of glaucoma patients were unable to correctly instill eye drops. Age was an independent factor associated with eye drop instillation performance.
DOI: 10.6084/m9.figshare.7101488.v1
title: Ophthalmic evaluation, treatment, and follow-up of two cases of incontinentia pigmenti

description: Incontinentia pigmenti (IP) is an X-linked dominant disorder affecting the skin, teeth, eyes, and central nervous system. Ocular changes are common and may lead to severe vision loss. We report on the ocular manifestations in two young girls with IP, with emphasis on the asymmetry of this condition in both eyes and associated retinal problems. The outcomes of laser treatment of the ischemic peripheral retina were good and resulted in stability of vision.
DOI: 10.6084/m9.figshare.7101491.v1
title: Treatment of astigmatism during phacoemulsification

description: Purpose: To compare the effectiveness of limbal relaxing incisions (LRI) with that of toric intraocular lens (IOL) implantation for the treatment of astigmatism during phacoemulsification using nonvectorial (predictability, safety, and efficacy) and vectorial analyses. Methods: This longitudinal observational case series assessed 62 eyes of 31 consecutive cataract patients with preoperative corneal astigmatism of 0.75-2.50 diopters (D) in both eyes. Patients were randomly assigned to 2 groups: a toric IOL group, which received toric IOLs in both eyes, and an LRI group, which received spherical IOLs associated with LRI placement in both eyes. All patients were evaluated at 1, 3, and 6 months after surgery, when refractive astigmatism analysis was performed using both nonvectorial and Alpins vectorial methods. Outcomes were assessed within each group and compared between groups. Results: The proportion of eyes within ±0.50 D of the intended correction at 3 and 6 months after surgery was 75% and 71.88%, respectively, in the LRI group and 40% and 66.67%, respectively, in the toric IOL group. In the remaining period, the proportion was greater in the toric IOL group. The safety index showed no difference at any time point. The efficacy index at 1 and 3 months after surgery was significantly higher in the toric IOL group (0.43 and 0.44, respectively) than in the LRI group (0.31 and 0.36, respectively). At 6 months after surgery, the status of eyes in the LRI group was as follows: 53.13% were undercorrected, 43.74% achieved the intended correction, and 3.13% were overcorrected. In the toric IOL group, 16.76% eyes were undercorrected, 76.67% achieved the intended correction, and 6.67% were overcorrected. The success rates for astigmatic surgery, astigmatism reduction at the intended axis, and astigmatism corrected were 43%, 62%, and 64%, respectively, in the LRI group and 57%, 81%, and 94%, respectively, in the toric IOL group. Conclusions: Our results suggest that the use of toric IOLs may be advantageous over the use of LRIs for the treatment of astigmatism during phacoemulsification. Although such advantages seem subtle in nonvectorial analyses, they are highlighted in vectorial analyses.
DOI: 10.6084/m9.figshare.7101485
title: Palliative Care: Importance of the Subject for Medical Students

description: ABSTRACT Introduction Palliative care are actions that seek to act on the quality of life of sick people and their families, alleviating and preventing suffering in the face of a terminal illness. The insertion of the palliative care theme in the undergraduate medical curriculum offers possibilities for future physicians to face the limitations / implications that they will undergo in their professional life and even during graduation. Objective To identify the importance of the Palliative Care theme for undergraduate students in Medicine. Methodology This is a quantitative, descriptive and cross-sectional study. An adapted version of the Instrument “PEAS – Physicians’ End-of-Life Care Attitude Scale” was used as instrument. 37 Likert-type questions were used to meet the aims of the study. The collection was made in 2015, in a random, non-probabilistic sample, composed of 134 students who were attending the last two years (internship) of Medicine School of a Brazilian Federal University. Data were analyzed in the SPSS program. Results Of the 134 participants, 59.7% were female, aged between 22 and 37 years. The results indicate that 85.84% of students need some supervision or basic instruction to discuss palliative care and withdrawal of treatment with patients and their families. Regarding the clinical management of the terminal patient, 78.35% consider themselves capable of handling alone or under minimal supervision, symptoms such as constipation or vomiting, but only 19.05% consider themselves capable of handling symptoms such as terminal delirium or dyspnea. Although 41.8% of students do not care about their own death, 88.1% feel anxious or uncomfortable about the death of their patient. The inclusion in the medical curriculum of communication skills in Palliative Care and end-of-life ethics was considered important or very important by 95.5% of the students interviewed. Conclusion Data showed that the students identify the deficiencies caused by the absence or limitation of the Palliative Care teaching during graduation and are interested in seeing the theme included as a discipline in the medical curriculum, which suggests further studies on the topic.
DOI: 10.6084/m9.figshare.7101485.v1
title: Palliative Care: Importance of the Subject for Medical Students

description: ABSTRACT Introduction Palliative care are actions that seek to act on the quality of life of sick people and their families, alleviating and preventing suffering in the face of a terminal illness. The insertion of the palliative care theme in the undergraduate medical curriculum offers possibilities for future physicians to face the limitations / implications that they will undergo in their professional life and even during graduation. Objective To identify the importance of the Palliative Care theme for undergraduate students in Medicine. Methodology This is a quantitative, descriptive and cross-sectional study. An adapted version of the Instrument “PEAS – Physicians’ End-of-Life Care Attitude Scale” was used as instrument. 37 Likert-type questions were used to meet the aims of the study. The collection was made in 2015, in a random, non-probabilistic sample, composed of 134 students who were attending the last two years (internship) of Medicine School of a Brazilian Federal University. Data were analyzed in the SPSS program. Results Of the 134 participants, 59.7% were female, aged between 22 and 37 years. The results indicate that 85.84% of students need some supervision or basic instruction to discuss palliative care and withdrawal of treatment with patients and their families. Regarding the clinical management of the terminal patient, 78.35% consider themselves capable of handling alone or under minimal supervision, symptoms such as constipation or vomiting, but only 19.05% consider themselves capable of handling symptoms such as terminal delirium or dyspnea. Although 41.8% of students do not care about their own death, 88.1% feel anxious or uncomfortable about the death of their patient. The inclusion in the medical curriculum of communication skills in Palliative Care and end-of-life ethics was considered important or very important by 95.5% of the students interviewed. Conclusion Data showed that the students identify the deficiencies caused by the absence or limitation of the Palliative Care teaching during graduation and are interested in seeing the theme included as a discipline in the medical curriculum, which suggests further studies on the topic.
DOI: 10.6084/m9.figshare.7101473
title: Evaluation of the efficacy of filling material removal and re-filling after different retreatment procedures

description: Abstract This study analyzed the influence of different retreatment protocols on amount of remaining filling material and amount of new sealer after endodontic retreatment. Forty mandibular molars with curved mesial roots were prepared with ProTaper Universal system, and filled with AH Plus sealer mixed with 0.1% rhodamine B and gutta-percha. After 7 days, the specimens were randomized according to the retreatment protocol (n = 10): ProTaper Retreatment System (PTR); PTR+Orange Oil (PTR+OO); PTR+Passive Ultrasonic Irrigation (PTR+PUI). No retreatment was performed in the control group (CG). After retreatment, the root canals were filled with AH Plus mixed with 0.1% fluorescein and gutta-percha. Samples were evaluated under confocal laser scanning microscopy and analyzed using Image J software. Data were analyzed using Kruskal-Wallis and Dunn tests (p &lt; 0.05). Regarding presence of residual filling, the Kruskal-Wallis test indicated no differences among the different retreatment techniques in the perimeter and the isthmus analyses (p &gt; 0.05); however, PTR+PUI was associated with a lesser amount of residual filling material in the canal area analysis (p &lt; 0.05). In evaluating the new filling, the perimeter analysis showed a lesser amount of new endodontic sealer in the PTR group (p &lt; 0.05). Moreover, the PTR+PUI group presented a significantly greater amount of new endodontic sealer in the canal area analysis (p &lt; 0.05). There was no difference among groups in the isthmus analysis (p &gt; 0.05). It can be concluded that PTR associated to PUI yielded better results in removing root canal filling material from the canal area. However, none of the protocols resulted in root walls completely free of remnants.