cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.5281/zenodo.1287253
title: Human Dolichyl-Phosphate Alpha-N-Acetyl Glucosaminyl Transferase (Dpagt1); A Target Enabling Package

description: The ER integral membrane enzyme dolichyl-phosphate alpha-N-acetyl glucosaminyl phosphotransferase (DPAGT1) catalyses the first step in the synthesis of the oligosaccharide-P-P-dolichol unit which provides the glycans structure for N-glycosylation of proteins. Mutations in DPAGT1 cause two muscle weakness conditions, limb-girdle congenital myasthenic syndrome (CMS) and congenital disorder of glycosylation type 1j (CDG1j). DPAGT1 overexpression has also been implicated in oral cancer. We have produced and solved structures of this integral membrane enzyme, DPAGT1 with the V264G mutation found in a patient with CMS, and complexes with a 50 nM inhibitor, tunicamycin. We have developed enzymatic activity and thermostability assays which have allowed us to assess the activity and stability of DPAGT1 mutants and the effect of small molecules. There are &gt; 20 DPAGT1 associated missense variants in patients with CMS and CDG1j. We have mapped these mutations to the structure, and we will used the assays described here to assess how the activity and stability of DPAGT1 is affected by these missense variants.
description: This document represents version 4 of the TEP datasheet and includes all updates on the project as of June 2018.  For more information about TEPs and the TEP Programme, please visit https://thesgc.org/tep.
DOI: 10.5281/zenodo.1287254
title: Human Lysine Demethylase Jmjd1B (Kdm3B); A Target Enabling Package

description: There are 3 members of the Lysine Demethylase JMJD1 (KDM3) family, JMJD1A-C. SGC Oxford has expressed, purified and crystallized the catalytic domains of JMJD1A, JMJD1B and JMJD1C as part of the probe programme. Fragment screening and X-ray crystallography identified a large number of binders, some of which were progressed into a medicinal chemistry programme. Despite significant effort molecules with probe properties were not obtained. Consequently it has been decided to put the information generated into the public domain.
description: The work at the SGC has been supported by the Innovative Medicines Initiative Joint Undertaking (IMI JU) under grant agreement [115766].

This document represents version 4 of the TEP datasheet and includes all updates on the project as of June 2018.  For more information about TEPs and the TEP Programme, please visit https://thesgc.org/tep.
DOI: 10.18169/papdeottx00791
title: Vollautomatische Detektion pathologischer Gefaessveraenderungen in tomographischen Bilddaten
DOI: 10.18169/papdeottx00792
title: Strahler fuer AX-Anwendungen
DOI: 10.18169/papdeottx00793
title: Verfahren zur Bestimmung der individuellen Verzeichniskoeffizienten von Gradientenspulen
DOI: 10.18169/papdeottx00794
title: Universal Programming Adapter for Different Battery Sizes and Positions
DOI: 10.18169/papdeottx00795
title: Partial Importing of PLC Charts across Different Versions of a Product with Minimum Loss of Data
DOI: 10.18169/papdeottx00796
title: Ueberspannungsableiter im Kaefigdesign
DOI: 10.18169/papdeottx00797
title: Koloskopie-Navigation mit MS-Surface-artigen Techniken
DOI: 10.18169/papdeottx00798
title: Bewegliche Portalserviceoption zur Steigerung der Zugaenglichkeit zu den Bestueckkoepfen
DOI: 10.18169/papdeottx00799
title: Befestigung von Vogelschutzkappen mittels Kabelbinder
DOI: 10.5281/zenodo.1287256
title: Human With No Lysine Kinase 3 (Wnk3); A Target Enabling Package

description: Kinases WNK1-4 regulate cation-chloride cotransporters via phosphorylation of SPAK and OSR1 and thereby control salt homeostasis, cell volume and blood pressure. Gain of function mutations in WNK kinases are found in Gordon’s hypertension syndrome suggesting the WNK pathway as a therapeutic target. WNK3 inhibition in particular has also been shown to reduce cerebral injury after Ischemic stroke. Here we present assays and crystal structures that define (i) the molecular basis for disease mutations; (ii) the multiple functional domains of WNK kinases and their protein interactions; (iii) the binding of small molecule kinase inhibitors and a potential allosteric pocket.
description: This document represents version 4 of the TEP datasheet and includes all updates on the project as of June 2018.  For more information about TEPs and the TEP Programme, please visit https://thesgc.org/tep.
DOI: 10.5281/zenodo.1287259
title: Human Pleckstrin Homology Domain Interacting Protein (Phip); A Target Enabling Package

description: SGC Oxford has expressed, purified and crystallized the second bromodomain of PHIP as part of the probe programme. Fragment screening and X-ray crystallography identified binders, some of which optimised to uM affinity. However, molecules with probe properties were not obtained. Consequently it has been decided to put the information generated into the public domain.
description: The work at the SGC has been supported by the Innovative Medicines Initiative Joint Undertaking (IMI JU) under grant agreement [115766].
This document represents version 4 of the TEP datasheet and includes all updates on the project as of June 2018.  For more information about TEPs and the TEP Programme, please visit https://thesgc.org/tep.
DOI: 10.5287/bodleian:y5r1z6ev7
title: Uphoff 2018 PNAS: Real-time dynamics of mutagenesis reveal the chronology of DNA repair and damage tolerance responses in single cells
DOI: 10.18169/papdeottx00800
title: Einfuehrung einer Gewichtungsfunktion zur Verbesserung der Bildqualitaet von Roentgenbildern
DOI: 10.18169/papdeottx00801
title: Bestimmung der Nadelkruemmung bei Nadelinterventionen
DOI: 10.18169/papdeottx00802
title: Automatisierbare Aenderung von Schutzparametern durch Zuordnung des Parameters zu einem logischen Eingangssignal
DOI: 10.18169/papdeottx00803
title: A Hearing instrument with water sensor detector
DOI: 10.18169/papdeottx00804
title: Verfahren zur Unterstuetzung bei der Diagnostik von Herzrhythmuserkrankungen
DOI: 10.18169/papdeottx00805
title: Apparatur und Verfahren zur Erfassung und Darstellung zum jeweiligen Zeitpunkt moeglicher Betriebsarten von MGCE Kapseln
DOI: 10.18169/papdeottx00806
title: Authentifizierung von Personen auf Basis von polygraphischen, nicht charakteristischen Merkmalen
DOI: 10.18169/papdeottx00807
title: Bewegungskompensation bei der Roentgen-3D-Bildgebung mittels Ultraschall
DOI: 10.18169/papdeottx00808
title: Verfahren zur Minimierung des Schleppfehlers einer Antriebsachse durch Aufschaltung einer Kompensationsgroesse, die mit Hilfe eines Reglers erzeugt wird
DOI: 10.18169/papdeottx00809
title: Battery Cover for In-the-Ear Custom Hearing Instruments
DOI: 10.5281/zenodo.1287260
title: Human Lim Domain Kinase 1 (Limk1), Kinase Domain; A Target Enabling Package

description: Loss of the translational repressor FMRP in fragile X syndrome causes upregulation of the type II BMP receptor BMPR2 and its non-canonical signalling via the kinase LIMK1. LIMK1 performs inhibitory phosphorylation on cofilin proteins blocking their actin-severing activity. Excessive BMPR2-LIMK1 activation was associated with dendritic spine and behavioural defects in animal models that could be rescued by BMPR2 knockdown or LIMK1 inhibition. Here we present a target enabling package for the therapeutic target LIMK1. We include crystal structures of BMPR2, LIMK1, LIMK2 and the LIMK1-cofilin complex, as well as multiple assays for small molecule inhibitor screening. Finally, we identify a series of allosteric LIMK1 inhibitors with promising potency and selectivity that may potentially allow the development of a safe drug for this chronic indication.
description: This document represents version 4 of the TEP datasheet and includes all updates on the project as of June 2018.  For more information about TEPs and the TEP Programme, please visit https://thesgc.org/tep.
DOI: 10.18169/papdeottx00810
title: Drehflansch 360°
DOI: 10.18169/papdeottx00811
title: Einsteckbare Transportrollen fuer Paletten
DOI: 10.18169/papdeottx00812
title: Im-Ohr-Hoergeraetebauform mit Richtmikrofon
DOI: 10.18169/papdeottx00813
title: Innovative Form der kombinierten Visualisierung von 3D- und Fluoro-/Durchleuchtungsbildern
DOI: 10.18169/papdeottx00814
title: Verfahren zur Bestimmung der optimalen Dominante in der medizinischen, roentgenbasierten Bildgebung
DOI: 10.18169/papdeottx00815
title: Pressverbindung fuer Hochstromanlagen
DOI: 10.18169/papdeottx00816
title: Energiegewinnung aus Wirbelschleppen von Flugzeugen
DOI: 10.18169/papdeottx00817
title: Adaptiver Rillschlauch und verkapselte Gehaeuse in der Medizintechnik
DOI: 10.18169/papdeottx00818
title: Certificate Validation Check Proxy
DOI: 10.5517/ccdc.csd.cc1pfczg
title: CCDC 1561996: Experimental Crystal Structure Determination

description: Related Article: Shun Yao, Gaojian Zhang, Haiyan Wang, Jinjin Song, Tianyan Liu, Mingdi Yang, Jianhua Yu, Xingyuan Yang, Yupeng Tian, Xuanjun Zhang, Hongping Zhou|2018|Sens.Actuators,B|272|574|doi:10.1016/j.snb.2018.05.143
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.18169/papdeottx00819
title: Digitalisierung von Standardformularen z.B. des Patienteninterviews/Einverstaendniserklaerung
DOI: 10.18169/papdeottx00820
title: Dreidimensionale Bestimmung und Visualisierung der zerebralen Haemodynamik mittels Bolusankunftszeiten
DOI: 10.18169/papdeottx00821
title: 3D-Visualisierung von Ablations-Laesionen via Farbcodierung des intrakardialen EKG
DOI: 10.18169/papdeottx00822
title: Prozess und Kosten optimierte Anwendungen zur Erzeugung von "quasi" sterilen Oberflaeche fuer Medizinprodukte
DOI: 10.18169/papdeottx00823
title: Dual Swirler Ultra Low NOx Combustion System
DOI: 10.18169/papdeottx00824
title: Ultra Low NOx Combustion System II
DOI: 10.18169/papdeottx00825
title: Schaltmechanismus fuer Schaltgeraet mit integriertem Kontaktsystem im Koppelelement
DOI: 10.18169/papdeottx00826
title: DALI EVGs bei Nichtbenutzung automatisch ausschalten
DOI: 10.18169/papdeottx00827
title: Multifunktionsscheibe
DOI: 10.5281/zenodo.1287824
title: Data Providers Package For Reporting Monitoring Results For Veterinary Medicinal Product Residues (Official Data Reporting Phase)

description: This data providers package provides the data collection configuration and supporting materials for reporting veterinary medicinal product residues (VMPR) results according to Council Directive 96/23/EC of 29 April 1996 on measures to monitor certain substances and residues thereof in live animals and animal products and repealing Directives 85/358/EEC and 86/469/EEC and Decisions 89/187/EEC and 91/664/EEC. These are to be used for the official data reporting phase.

The package includes:

Advice on the values to be reported for the mandatory fields specified for this data collection.

The Standard Sample Description Version 2 XML schema definition for VMPR reporting.

The STX transformation file which automatically assigns sampEventId and sampAnId when this information is not provided.

The general and VMPR specific business rules applied for the automatic validation of the submitted datasets.

The VMPR specific terminologies to be used for reporting analytical methods and the residues included in the scope of the analytical methods.

An example of a reportable dataset following the Quick Start Reporting guide.

Excel Mapping tool to convert excel files after mapping into XML document.

Guidance on how to use the Excel Mapping tool.

Guidance on how to run the validation report after submitting data to the DCF.
description: data.collection@efsa.europa.eu
DOI: 10.5517/ccdc.csd.cc1z2024
title: CCDC 1819175: Experimental Crystal Structure Determination

description: Related Article: Kelsey E. Poremba,  Nathaniel T. Kadunce,  Naoyuki Suzuki,  Alan H. Cherney,  Sarah E. Reisman|2018|J.Am.Chem.Soc.|140|7746|doi:10.1021/jacs.8b05247
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc1z32dk
title: CCDC 1820208: Experimental Crystal Structure Determination

description: Related Article: Yuki Inoue,  Daisuke Sakamaki,  Yusuke Tsutsui,  Masayuki Gon,  Yoshiki Chujo,  Shu Seki|2018|J.Am.Chem.Soc.|140|7152|doi:10.1021/jacs.8b02689
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc1z32fl
title: CCDC 1820209: Experimental Crystal Structure Determination

description: Related Article: Yuki Inoue,  Daisuke Sakamaki,  Yusuke Tsutsui,  Masayuki Gon,  Yoshiki Chujo,  Shu Seki|2018|J.Am.Chem.Soc.|140|7152|doi:10.1021/jacs.8b02689
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc1z32gm
title: CCDC 1820210: Experimental Crystal Structure Determination

description: Related Article: Yuki Inoue,  Daisuke Sakamaki,  Yusuke Tsutsui,  Masayuki Gon,  Yoshiki Chujo,  Shu Seki|2018|J.Am.Chem.Soc.|140|7152|doi:10.1021/jacs.8b02689
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc1z32hn
title: CCDC 1820211: Experimental Crystal Structure Determination

description: Related Article: Yuki Inoue,  Daisuke Sakamaki,  Yusuke Tsutsui,  Masayuki Gon,  Yoshiki Chujo,  Shu Seki|2018|J.Am.Chem.Soc.|140|7152|doi:10.1021/jacs.8b02689
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.18169/papdeottx00828
title: Keramikbeschichtete PET-Folien als Traegermaterial fuer die Herstellung von Staender- und Laeuferwicklungen
DOI: 10.18169/papdeottx00829
title: Realisierung von daempfungsoptimierten MR- Lokalspulengehaeusen fuer PET-Anwendungen
DOI: 10.18169/papdeottx00830
title: Powder Coating on the Hearing Instrument
DOI: 10.18169/papdeottx00831
title: Mechanism to Trigger the Opening/Closure of a Vent when it Detects Moisture
DOI: 10.18169/papdeottx00832
title: Individualized Stents for Treatment of Aneurysms
DOI: 10.18169/papdeottx00833
title: Auswertung von Motorbetriebsgroessen durch eine in den Elektromotor integrierte Elektronik
DOI: 10.18169/papdeottx00834
title: Automatischer SMS Versand im Falle eines Kompressorfehlers mittels GSM Modem
DOI: 10.18169/papdeottx00835
title: Workflow zur integrierten Erfassung und Vermessung von Netzopologien
DOI: 10.18169/papdeottx00836
title: Kombination von Sprachdialog und Ortungsverfahren fuer Kommissionierungssysteme
DOI: 10.5517/ccdc.csd.cc1z32jp
title: CCDC 1820212: Experimental Crystal Structure Determination

description: Related Article: Yuki Inoue,  Daisuke Sakamaki,  Yusuke Tsutsui,  Masayuki Gon,  Yoshiki Chujo,  Shu Seki|2018|J.Am.Chem.Soc.|140|7152|doi:10.1021/jacs.8b02689
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc1z38bp
title: CCDC 1820392: Experimental Crystal Structure Determination

description: Related Article: Xingjie Zhang,  Xin Xie,  Yuanhong Liu|2018|J.Am.Chem.Soc.|140|7385|doi:10.1021/jacs.8b02542
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc1z4rb6
title: CCDC 1821818: Experimental Crystal Structure Determination

description: Related Article: Jiong Zhou,  Yuzhen Zhang,  Guocan Yu,  Matthew R Crawley,  Cressa Ria Palencia Fulong,  Alan Eric Friedman,  Sanghamitra Sengupta,  Jifu Sun,  Qing Li,  Feihe Huang,  Timothy R. Cook|2018|J.Am.Chem.Soc.|140|7730|doi:10.1021/jacs.8b04929
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.18169/papdeottx00837
title: Robotergestuetzte Registrierung von Roentgenbildern und Ultraschallbildern
DOI: 10.18169/papdeottx00838
title: Schonende Fixierung schwer uebergewichtiger Patienten
DOI: 10.18169/papdeottx00839
title: Kabelschwanzintegration am Gebergehaeuse
DOI: 10.18169/papdeottx00840
title: Drehbare Stecker mit Zentralschraube zur Fixierung
DOI: 10.18169/papdeottx00841
title: Equalizer Hearing Aid
DOI: 10.18169/papdeottx00842
title: Strahlungsfreie Positionier- und Zentrierhilfe fuer C-Arm-Angiographiesysteme
DOI: 10.18169/papdeottx00843
title: Digitales Token zur Realisierung sicherungstechnischer Abhaengigkeiten im Bahnbetrieb unter Nutzung der drahtlosen Transponder/Reader-Technologie
DOI: 10.18169/papdeottx00844
title: Vorrichtung zur Absicherung der Notversorgung mit Schmieroel in Oelversorgungssystemen fuer Turbomaschinen
DOI: 10.18169/papdeottx00845
title: Referenzdatenbank fuer dedizierte klinische Empfehlungen
DOI: 10.4225/08/5b1f61c5dc97b
title: Parkes observations for project P892 semester 2018APRS_BPSR_18

description: SUPERBx looks at the highest Galactic latitudes in a search for pulsars and fast radio bursts (FRBs). We use optimised GPU codes and supercomputing to search for these, making discoveries in real time. Handling our data as it comes in is essential for the SKA Phase I era so this work applies directly to the high-data rates of next generation telescopes. Our pulsar discoveries are typically nearby scintillating sources, intermittent sources and those in interesting binary systems. Our FRB discoveries have discovery lags of ~1 second, rather than months/years and these feed rapid alerts to the world-wide follow-up community via a dedicated VOEvent format an Astronomer's Telegrams. The goal of this is to allow localisation of the discovered FRBs. This is key for identifying FRB host galaxies, so as to solve the mystery of their progenitors and to exploit their many uses as tools for precision cosmology measurements.
DOI: 10.4225/08/5b1f61c90a44e
title: Parkes observations for project P892 semester 2018APRS_BPSR_19

description: SUPERBx looks at the highest Galactic latitudes in a search for pulsars and fast radio bursts (FRBs). We use optimised GPU codes and supercomputing to search for these, making discoveries in real time. Handling our data as it comes in is essential for the SKA Phase I era so this work applies directly to the high-data rates of next generation telescopes. Our pulsar discoveries are typically nearby scintillating sources, intermittent sources and those in interesting binary systems. Our FRB discoveries have discovery lags of ~1 second, rather than months/years and these feed rapid alerts to the world-wide follow-up community via a dedicated VOEvent format an Astronomer's Telegrams. The goal of this is to allow localisation of the discovered FRBs. This is key for identifying FRB host galaxies, so as to solve the mystery of their progenitors and to exploit their many uses as tools for precision cosmology measurements.
DOI: 10.5281/zenodo.1287828
title: Output From: Small Room For Compromise Between Oil Palm Cultivation And Primate Conservation In Africa

description: Expected results from the scripts associated to the paper<strong>:</strong>

<strong>Strona G., S. D. Stringer, G. Vieilledent, Z. Szantoi, J. Garcia-Ulloa, S. Wich.</strong> Small room for compromise between oil palm cultivation and primate conservation in Africa.
DOI: 10.5281/zenodo.1288673
title: Robustness Assessment Through Iterative Statistical Fault Injection: Leon3 Processor As A Case Study

description: <strong>Dataset exemplifies an approach of iterative statistical fault injection to assess the robustness of HDL models.</strong>

Contents:<br>
1. Results of exhaustive fault injection experiments (bit-flip faults) into LEON3 processor model;<br>
2. Interactive querying interface, allowing to obtain custom samples from exhaustive results, and visualize them;<br>
3. Python scripts simulating 3 approaches to statistical fault injection: conservative, error-driven, time-driven.

 

<strong>Installation guide:</strong>

        1. Ensure to have python ver. 2.x installed. Type in terminal (cmd console in Windows): “python --version” – if the output looks like &gt; Python 2.x.x – python is installed. <br>
        Otherwise download and install 2.x.x distribution: https://www.python.org/<br>
        Add python installation path to environment path variable.

<br>
        2. Ensure to have Web-Server installed (Apache preferable). For instance, XAMPP: https://www.apachefriends.org/index.html

          <br>
        3. Ensure that Web-server is configured to execute CGI scripts, particularly python-scripts:<br>
        In the 'httpd.conf' file (XAMMP control panel – button config in front of apache module):<br>
         

        – search for line Options Indexes FollowSymLinks and add ExecCGI, so the resulting line looks like this: <br>
        Options Indexes FollowSymLinks ExecCGI<br>
        – search for #AddHandler cgi-script .cgi, uncomment (remove #), and append “.py” to this line, so the results looks like:<br>
        AddHandler cgi-script .cgi .pl .asp .py 

        4. Unpack the contents of *.zip package into the folder on the Web Server. <br>
        For instance into 'Web-server root folder'/Dataset.<br>
        The Web-Server root can be configured in the ‘httpd.conf’ file in the DocumentRoot section, for instance: <br>
        DocumentRoot "F:/HTWEB"<br>
        &lt;Directory "F:/HTWEB"&gt;<br>
        ...

        5. In the web-browser navigate to the root directory of extracted package:<br>
        http://localhost/Dataset/index.html