cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.23816194.v1
title: Genetic basis of ß-thalassemia in families of pashtun ethnicity in Dera Ismail Khan district of Khyber Pakhtun-Khwa province, Pakistan

description: The objective of current genetic research was to verify the genetic basis of ß-thalassemia and its pattern of inheritance in families of Pashtun ethnicity in District Dera Ismail Khan, Pakistan. Blood samples from clinically diagnosed five unrelated ß-thalassemia families were collected and target Sanger Sequencing of HBB gene was done. Moreover, in silico analysis including protein modeling and Protein-Protein docking was aslo performed. Clinical analysis of patients from family 1,2, 4, and 5 revealed Thalassemia Intermedia, while patient from family 3 was suffering from thalassemia major. The average Hb concentrations between the cases that were severe were found to be a little lower (6.3 mg/dl) than the patients with milder clinical manifestations (7.6 ± 1.4). Genetic analysis in family 1 identified compound heterozygous mutation of HBB (NM_000518) i.e. c.20A&gt;T +c.92 G&gt;A, in family 2 and 4 compound heterozygous mutations c.20A&gt;T + c.27_28insG, in family 3 homozygous mutation c.27_28insG, while in family 5 we identified homozygous mutation c.92 + 5 G&gt;C (IVS-1 + 5 G&gt;C). This study offers an effective incentive to establish a mutation detection as well as prenatal diagnosis (PND) centers at a larger scale in the Pashtun ethnicity residing in District Dera Ismail Khan, Pakistan.
DOI: 10.26050/wdcc/luc_future_na_v1.1
title: LUCAS LUC future land use and land cover change dataset for North America (Version 1.1)

description: Project: Modelling human LAND surface modifications and its feedbacks on local and regional cliMATE - The project “Modelling human LAND surface modifications and its feedbacks on local and regional climate” (LANDMATE, https://www.hicss-hamburg.de/projects/landmate/index.php.en) is carried out within the framework of the Helmholtz Institute for Climate Service Science (HICSS), a cooperation between Climate Service Center Germany (GERICS) of the Helmholtz-Zentrum Hereon and Universität Hamburg. Within LANDMATE, scientists from GERICS and the Institute of Geography (CEN, Universität Hamburg) investigate the direct biophysical effects of land use and land cover change on the local and regional climate. The overall objectives of this project are to: I) Better represent dynamic land use characteristics in a regional climate model, II) Include land management practices into a regional climate model, III) Quantify biophysical impacts of land use dynamics on regional climate variability and change in Europe in the frame of WCRP CORDEX Flagship Pilot Study “Land Use and Climate Across Scales” (LUCAS, https://ms.hereon.de/cordex_fps_lucas/). 
Summary: The LUCAS LUC future dataset consists of annual land use and land cover maps from 2016 to 2100 for North America. It is based on land cover data from the LANDMATE PFT dataset for the year 2015. The LANDMATE PFT consists of 16 plant functional types and non-vegetated classes that were converted from the ESA-CCI LC land cover data according to the method of Reinhart et al. (2022). For version 1.1 of the LUCAS LUC dataset, the improved LANDMATE PFT map version 1.1 was employed. The land use change information from the Land-Use Harmonization Data Set version 2 (LUH2 v2.1f, Hurtt et al. 2020) were imposed using the land use translator developed by Hoffmann et al. (2023). The projected land use change information was derived for different Shared Socioeconomic Pathways (SSPs) and Representative Concentration Pathways (RCPs) combinations used in the framework of the 6th phase of Coupled Modelling Intercomparison Project (CMIP6). For each year, a map is provided that contains 16 fields. Each field holds the fraction the respective plant functional types and non-vegetated classes in the total grid cell (0-1). The LUCAS LUC dataset was constructed within the HICSS project LANDMATE and the WCRP flagship pilot study LUCAS to meet the requirements of downscaling experiments within CORDEX.
Plant functional types and non-vegetative classes:
1 - Tropical broadleaf evergreen trees
2 - Tropical deciduous trees
3 - Temperate broadleaf evergreen trees
4 - Temperate deciduous trees
5 - Evergreen coniferous trees
6 - Deciduous coniferous trees
7 - Coniferous shrubs
8 - Deciduous shrubs
9 - C3 grass
10 - C4 grass
11 - Tundra
12 - Swamp
13 - Non-irrigated crops
14 - Irrigated crops
15 - Urban
16 - Bare
DOI: 10.6084/m9.figshare.19097631
title: miR-30b-5p inhibits osteoblast differentiation through targeting BCL6

description: Human bone marrow mesenchymal stem cells (hBMSCs) are attractive candidates for new therapies to improve bone regeneration and repair. This study was to identify the function of the miR-30b-5p/BCL6 axis in osteogenic differentiation of hBMSCs. Realtime-quantitative PCR (RT-qPCR) and Western blotting were used to measure the relative expression of ALP, OCN, RUNX2, miR-30b-5p, and BCL6 during osteogenic differentiation of hBMSCs. The relationship between miR-30b-5p and BCL6 in hBMSCs was identified using dual-luciferase reporter system and RNA pull-down assay. Alizarin red S staining (ARS) was used to detect the calcium nodules in hBMSCs. We found that the expression of miR-30b-5p was downregulated, whereas that of BCL6 was upregulated during osteogenic differentiation of hBMSCs. Downregulating miR-30b-5p enhanced the expression of OCN, RUNX2, and ALP, and promoted calcium deposition. Conversely, transfection with si-BCL6 had the opposite effect that it inhibited osteogenic differentiation. However, the inhibitory effect of si-BCL6 was abrogated by miR-30b-5p inhibitor. miR-30b-5p inhibits the osteogenic differentiation of hBMSCs by targeting BCL6.
DOI: 10.6084/m9.figshare.24346977
title: Identification of mitochondria-related action targets of quercetin in melanoma cells

description: Melanoma is a complex and genetically heterogeneous malignant tumor with high rates of mortality. Although current therapies provide a short-term clinical benefit, they are unable to cure the majority of patients with metastatic melanoma. Therefore, the investigation of pathological mechanisms and the development of new therapy strategies for melanoma are of great significance. Quercetin can effectively inhibit tumor growth in various tumors. However, the exact action mechanisms of quercetin against melanoma have not been comprehensively clarified, which limits its application. Accumulating evidence has suggested that the dysfunction of mitochondria is closely linked to carcinogenesis, and a better understanding of the regulation of mitochondria-related genes will shed light on providing new therapies for melanoma. In this study, we performed RNA-seq from melanoma B16-F1 cells treated with quercetin versus controls and screened for differentially expressed genes (DEGs). GO and KEGG enrichment analyses were performed, and a protein–protein interaction (PPI) network was constructed. Combining the results of RNA-seq, molecular docking, and bioinformatics analysis, we found six mitochondria-related genes, BTG2, CP, LRIG1, CYP1A1, GBP2, and MBNL1, which might be targets of quercetin in melanoma and provide an available targeting therapy strategy for melanoma.
DOI: 10.6084/m9.figshare.24346977.v1
title: Identification of mitochondria-related action targets of quercetin in melanoma cells

description: Melanoma is a complex and genetically heterogeneous malignant tumor with high rates of mortality. Although current therapies provide a short-term clinical benefit, they are unable to cure the majority of patients with metastatic melanoma. Therefore, the investigation of pathological mechanisms and the development of new therapy strategies for melanoma are of great significance. Quercetin can effectively inhibit tumor growth in various tumors. However, the exact action mechanisms of quercetin against melanoma have not been comprehensively clarified, which limits its application. Accumulating evidence has suggested that the dysfunction of mitochondria is closely linked to carcinogenesis, and a better understanding of the regulation of mitochondria-related genes will shed light on providing new therapies for melanoma. In this study, we performed RNA-seq from melanoma B16-F1 cells treated with quercetin versus controls and screened for differentially expressed genes (DEGs). GO and KEGG enrichment analyses were performed, and a protein–protein interaction (PPI) network was constructed. Combining the results of RNA-seq, molecular docking, and bioinformatics analysis, we found six mitochondria-related genes, BTG2, CP, LRIG1, CYP1A1, GBP2, and MBNL1, which might be targets of quercetin in melanoma and provide an available targeting therapy strategy for melanoma.
DOI: 10.6084/m9.figshare.22767543
title: Additional file 9 of Transcriptome-wide analysis of RNA m6A methylation regulation of muscle development in Queshan Black pigs

description: Additional file 9: Table S9. All KEGG pathways for the DEGs.
DOI: 10.6084/m9.figshare.19097631.v1
title: miR-30b-5p inhibits osteoblast differentiation through targeting BCL6

description: Human bone marrow mesenchymal stem cells (hBMSCs) are attractive candidates for new therapies to improve bone regeneration and repair. This study was to identify the function of the miR-30b-5p/BCL6 axis in osteogenic differentiation of hBMSCs. Realtime-quantitative PCR (RT-qPCR) and Western blotting were used to measure the relative expression of ALP, OCN, RUNX2, miR-30b-5p, and BCL6 during osteogenic differentiation of hBMSCs. The relationship between miR-30b-5p and BCL6 in hBMSCs was identified using dual-luciferase reporter system and RNA pull-down assay. Alizarin red S staining (ARS) was used to detect the calcium nodules in hBMSCs. We found that the expression of miR-30b-5p was downregulated, whereas that of BCL6 was upregulated during osteogenic differentiation of hBMSCs. Downregulating miR-30b-5p enhanced the expression of OCN, RUNX2, and ALP, and promoted calcium deposition. Conversely, transfection with si-BCL6 had the opposite effect that it inhibited osteogenic differentiation. However, the inhibitory effect of si-BCL6 was abrogated by miR-30b-5p inhibitor. miR-30b-5p inhibits the osteogenic differentiation of hBMSCs by targeting BCL6.
DOI: 10.6084/m9.figshare.22767657
title: The data for wild gibbons plan their travel pattern from Wild gibbons plan their travel pattern according to food types of breakfast

description: Planning for the future is a complex skill that is often considered uniquely human. This cognitive ability has never been investigated in wild gibbons (Hylobatidae). Here we evaluated the movement patterns from sleeping trees to out-of-sight breakfast trees in two groups of endangered skywalker gibbons (<i>Hoolock tianxing</i>). These Asian apes inhabit a cold seasonal montane forest in southwestern China. After controlling for possible confounding variables including group size, sleeping pattern (sleep alone or huddle together), rainfall and temperature, we found that food type (fruits or leaves) of the breakfast tree was the most important factor affecting gibbon movement patterns. Fruit breakfast trees were more distant from sleeping trees compared to leaf trees. Gibbons left sleeping trees and arrived at breakfast trees earlier when they fed on fruits compared to leaves. They travelled fast when breakfast trees located further away from the sleeping trees. Our study suggests that gibbons had foraging goals in mind and plan their departure times accordingly. This ability may reflect a capacity for route-planning, which would enable them to effectively exploit highly dispersed fruit resources in high altitude montane forests.
DOI: 10.6084/m9.figshare.22767534
title: Additional file 6 of Transcriptome-wide analysis of RNA m6A methylation regulation of muscle development in Queshan Black pigs

description: Additional file 6: Table S6. All KEGG pathways for the DMGs.
DOI: 10.6084/m9.figshare.22767531.v1
title: Additional file 5 of Transcriptome-wide analysis of RNA m6A methylation regulation of muscle development in Queshan Black pigs

description: Additional file 5: Table S5. All GO terms for the DMGs.
DOI: 10.6084/m9.figshare.22767534.v1
title: Additional file 6 of Transcriptome-wide analysis of RNA m6A methylation regulation of muscle development in Queshan Black pigs

description: Additional file 6: Table S6. All KEGG pathways for the DMGs.
DOI: 10.6084/m9.figshare.22767546
title: Additional file 10 of Transcriptome-wide analysis of RNA m6A methylation regulation of muscle development in Queshan Black pigs

description: Additional file 10: Table S10. Intersection of DMGs and DEGs.
DOI: 10.6084/m9.figshare.22767528
title: Additional file 4 of Transcriptome-wide analysis of RNA m6A methylation regulation of muscle development in Queshan Black pigs

description: Additional file 4: Table S4. Differentially methylated peaks (DMPs) in QA vs. QN.
DOI: 10.6084/m9.figshare.22767531
title: Additional file 5 of Transcriptome-wide analysis of RNA m6A methylation regulation of muscle development in Queshan Black pigs

description: Additional file 5: Table S5. All GO terms for the DMGs.
DOI: 10.6084/m9.figshare.22767537
title: Additional file 7 of Transcriptome-wide analysis of RNA m6A methylation regulation of muscle development in Queshan Black pigs

description: Additional file 7: Table S7. Differentially expressed genes (DEGs) in QA vs QN.
DOI: 10.6084/m9.figshare.24347002
title: MALDI-IMS_spectra_in_HER2<sup>+</sup>_gastric_cancer_tissues

description: The datasets includes the raw matrix-assisted laser desorption/ionization imaging mass spectra (MALDI-IMS) of each of the nine subpopulations from 49 patients with gastric cancer.
DOI: 10.6084/m9.figshare.22767552.v1
title: Additional file 12 of Transcriptome-wide analysis of RNA m6A methylation regulation of muscle development in Queshan Black pigs

description: Additional file 12: Table S12. All KEGG pathways for the intersection of DMGs and DEGs.
DOI: 10.6084/m9.figshare.22767546.v1
title: Additional file 10 of Transcriptome-wide analysis of RNA m6A methylation regulation of muscle development in Queshan Black pigs

description: Additional file 10: Table S10. Intersection of DMGs and DEGs.
DOI: 10.6084/m9.figshare.22767549
title: Additional file 11 of Transcriptome-wide analysis of RNA m6A methylation regulation of muscle development in Queshan Black pigs

description: Additional file 11: Table S11. All GO terms for the intersection of DMGs and DEGs.
DOI: 10.6084/m9.figshare.8094080
title: Genetic determination of sex and shell color in the Pacific abalone Haliotis discus hannai revealed by an integrated linkage map

description: Genotype data for the mapping families; Phenotype data for shell color and sex.
DOI: 10.6084/m9.figshare.22767549.v1
title: Additional file 11 of Transcriptome-wide analysis of RNA m6A methylation regulation of muscle development in Queshan Black pigs

description: Additional file 11: Table S11. All GO terms for the intersection of DMGs and DEGs.
DOI: 10.6084/m9.figshare.8094098
title: Genetic determination of sex and shell color in the Pacific abalone Haliotis discus hannai revealed by an integrated linkage map

description: Genotype data for the mapping families; Phenotype data for shell color and sex.
DOI: 10.6084/m9.figshare.22767657.v1
title: The data for wild gibbons plan their travel pattern from Wild gibbons plan their travel pattern according to food types of breakfast

description: Planning for the future is a complex skill that is often considered uniquely human. This cognitive ability has never been investigated in wild gibbons (Hylobatidae). Here we evaluated the movement patterns from sleeping trees to out-of-sight breakfast trees in two groups of endangered skywalker gibbons (<i>Hoolock tianxing</i>). These Asian apes inhabit a cold seasonal montane forest in southwestern China. After controlling for possible confounding variables including group size, sleeping pattern (sleep alone or huddle together), rainfall and temperature, we found that food type (fruits or leaves) of the breakfast tree was the most important factor affecting gibbon movement patterns. Fruit breakfast trees were more distant from sleeping trees compared to leaf trees. Gibbons left sleeping trees and arrived at breakfast trees earlier when they fed on fruits compared to leaves. They travelled fast when breakfast trees located further away from the sleeping trees. Our study suggests that gibbons had foraging goals in mind and plan their departure times accordingly. This ability may reflect a capacity for route-planning, which would enable them to effectively exploit highly dispersed fruit resources in high altitude montane forests.
DOI: 10.6084/m9.figshare.8087714
title: MOESM1 of Comparative analysis of differentially expressed genes between the ovaries from pregnant and nonpregnant goats using RNA-Seq

description: Additional file 1. Summary of the sequenced reads mapped to the Capra hircus reference genes and genome.
DOI: 10.6084/m9.figshare.8087738.v1
title: MOESM5 of Comparative analysis of differentially expressed genes between the ovaries from pregnant and nonpregnant goats using RNA-Seq

description: Additional file 5. Differential gene detected in two libraries.
DOI: 10.6084/m9.figshare.8087744.v1
title: MOESM6 of Comparative analysis of differentially expressed genes between the ovaries from pregnant and nonpregnant goats using RNA-Seq

description: Additional file 6. Gene Ontology (GO) classifications of two libraries.
DOI: 10.6084/m9.figshare.8087714.v1
title: MOESM1 of Comparative analysis of differentially expressed genes between the ovaries from pregnant and nonpregnant goats using RNA-Seq

description: Additional file 1. Summary of the sequenced reads mapped to the Capra hircus reference genes and genome.
DOI: 10.6084/m9.figshare.8087744
title: MOESM6 of Comparative analysis of differentially expressed genes between the ovaries from pregnant and nonpregnant goats using RNA-Seq

description: Additional file 6. Gene Ontology (GO) classifications of two libraries.
DOI: 10.6084/m9.figshare.8087717.v1
title: MOESM2 of Comparative analysis of differentially expressed genes between the ovaries from pregnant and nonpregnant goats using RNA-Seq

description: Additional file 2. All detected genes in the two libraries.
DOI: 10.5281/zenodo.10649385
title: Supplementary Material for "The Unreasonable Effectiveness of Large Language Models in Issuing Just-in-Time Adaptive Interventions: Fostering Physical Activity in a Prospective Cardiac Rehabilitation Setting"

description: This upload contains supplementary materials for the publication:

"The Last JITAI? - The Unreasonable Effectiveness of Large Language Models in Issuing Just-in-Time Adaptive Interventions: Fostering Physical Activity in a Prospective Cardiac Rehabilitation Setting"

Supplement 1: Persona and context information used as basis for JITAI decision-making and content generation

Supplement 2: Instructions given to JITAI generators 

Supplement 3: Data and analysis skripts (contains a Read_me file specifying further details)
DOI: 10.5281/zenodo.10649386
title: Supplementary Material for "The Unreasonable Effectiveness of Large Language Models in Issuing Just-in-Time Adaptive Interventions: Fostering Physical Activity in a Prospective Cardiac Rehabilitation Setting"

description: This upload contains supplementary materials for the publication:

"The Last JITAI? - The Unreasonable Effectiveness of Large Language Models in Issuing Just-in-Time Adaptive Interventions: Fostering Physical Activity in a Prospective Cardiac Rehabilitation Setting"

Supplement 1: Persona and context information used as basis for JITAI decision-making and content generation

Supplement 2: Instructions given to JITAI generators 

Supplement 3: Data and analysis skripts (contains a Read_me file specifying further details)
DOI: 10.5281/zenodo.10656771
title: DIAPASON Project: EMOTIONAL EXPERIENCES IN MALE AND FEMALE PATIENTS WITH SCHIZOPHRENIA SPECTRUM DISORDERS AND HEALTHY CONTROLS: AN EXPERIENCE SAMPLING METHOD STUDY

description: Dataset of the paper entitled "EMOTIONAL EXPERIENCES IN MALE AND FEMALE PATIENTS WITH SCHIZOPHRENIA SPECTRUM DISORDERS AND HEALTHY CONTROLS: AN EXPERIENCE SAMPLING METHOD STUDY" Italian Ministry of Health, Italy, Ricerca Finalizzata (Grant RF-2018-12365514) (https://www.diapason-study.eu/)
DOI: 10.5281/zenodo.10656772
title: DIAPASON Project: EMOTIONAL EXPERIENCES IN MALE AND FEMALE PATIENTS WITH SCHIZOPHRENIA SPECTRUM DISORDERS AND HEALTHY CONTROLS: AN EXPERIENCE SAMPLING METHOD STUDY

description: Dataset of the paper entitled "EMOTIONAL EXPERIENCES IN MALE AND FEMALE PATIENTS WITH SCHIZOPHRENIA SPECTRUM DISORDERS AND HEALTHY CONTROLS: AN EXPERIENCE SAMPLING METHOD STUDY" Italian Ministry of Health, Italy, Ricerca Finalizzata (Grant RF-2018-12365514) (https://www.diapason-study.eu/)
DOI: 10.6084/m9.figshare.22767552
title: Additional file 12 of Transcriptome-wide analysis of RNA m6A methylation regulation of muscle development in Queshan Black pigs

description: Additional file 12: Table S12. All KEGG pathways for the intersection of DMGs and DEGs.
DOI: 10.6084/m9.figshare.8087696
title: Additional file 2: of Enhancing the one health initiative by using whole genome sequencing to monitor antimicrobial resistance of animal pathogens: Vet-LIRN collaborative project with veterinary diagnostic laboratories in United States and Canada

description: A table with full summary of ARG and plasmid detections and NCBI isolate-level accession numbers. (XLSX 33 kb)
DOI: 10.6084/m9.figshare.8087687.v1
title: Additional file 1: of Enhancing the one health initiative by using whole genome sequencing to monitor antimicrobial resistance of animal pathogens: Vet-LIRN collaborative project with veterinary diagnostic laboratories in United States and Canada

description: Metadata entry template sheet. (XLSX 284 kb)
DOI: 10.6084/m9.figshare.23812406
title: Additional file 1 of Functional polymorphism in miR-208 is associated with increased risk for ischemic stroke

description: Supplementary Material 1
DOI: 10.6084/m9.figshare.23812400.v1
title: Additional file 3 of Biological reconstruction of bone defect after resection of malignant bone tumor by allograft: a single-center retrospective cohort study

description: Additional file 3: Supplementary videos. Video 1 Case 21. Video 2 Case 1. Video 3 Case 23. Video 4 Case 20. Video 5 Case 5.
DOI: 10.6084/m9.figshare.8087696.v1
title: Additional file 2: of Enhancing the one health initiative by using whole genome sequencing to monitor antimicrobial resistance of animal pathogens: Vet-LIRN collaborative project with veterinary diagnostic laboratories in United States and Canada

description: A table with full summary of ARG and plasmid detections and NCBI isolate-level accession numbers. (XLSX 33 kb)
DOI: 10.6084/m9.figshare.8087717
title: MOESM2 of Comparative analysis of differentially expressed genes between the ovaries from pregnant and nonpregnant goats using RNA-Seq

description: Additional file 2. All detected genes in the two libraries.
DOI: 10.6084/m9.figshare.12806071.v1
title: Additional file 5 of Proteomic analysis revealed common, unique and systemic signatures in gender-dependent hepatocarcinogenesis

description: Additional file 5: Figure S5. Bioinformatics analysis of DEPs during hepatocarcinogenesis in males and females.