cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.15468/dl.8nxnh4
title: Occurrence Download

description: A dataset containing 119 species occurrences available in GBIF matching the query:
{
 "and" : [
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 "TaxonKey is Kappaphycus alvarezii (Doty) Doty ex P.C.Silva",
 "Year 1925-2025"
 ]
}

 The dataset includes 119 records from 16 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0014041-250515123054153/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.ydt3up
title: Occurrence Download

description: A dataset containing 8938 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Ateles geoffroyi"
 ]
}

 The dataset includes 8938 records from 107 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0040457-250717081556266/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.5439/2572899
title: Merged aerosol size distribution from SMPS and OPC for SAIL

description: This dataset contains merged aerosol number size distribution data for the Surface Atmosphere Integrated Field Laboratory (SAIL) campaign. The merged size distribution data were constructed by combining measurements from a scanning-mobility particle sizer (SMPS) and an optical particle counter (OPC), covering a size range of 0.01–35 µm. The merging methodology follows the approach described by Hand and Kreidenweis (2002) and Marinescu et al. (2019). All aerosol data from the ARM archive were corrected to standard temperature (273.15 K) and pressure (101.3 kPa).
DOI: 10.15468/dl.k55fxp
title: Occurrence Download

description: A dataset containing 353 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Cuscuta pentagona",
 "Country is Japan",
 "HasCoordinate is true"
 ]
}

 The dataset includes 353 records from 20 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0040458-250717081556266/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.vd6vs2
title: Occurrence Download

description: A dataset containing 653 species occurrences available in GBIF matching the query:
{
 "and" : [
 "OccurrenceStatus is Present",
 "TaxonKey is Cabassous centralis"
 ]
}

 The dataset includes 653 records from 88 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0040460-250717081556266/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.ksfws2
title: Occurrence Download

description: A dataset containing 190 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Nolana galapagensis"
 ]
}

 The dataset includes 190 records from 13 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0040459-250717081556266/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.17900/slb.oct2020.v1
title: Historical Series of the Portuguese Banking Sector. Extraction: October 2020

description: Compilation/Synthesis
description: The Historical Series of the Portuguese Banking Sector data is collected and assembled by a working group at Banco de Portugal which was established at the end of 2017 with the objective of  constructing historical series on the Portuguese banking sector.
description: The Historical Series of the Portuguese Banking Sector Database includes information about banking groups and stand-alone institutions resident in Portugal. The coverage of financial institutions varies depending on the data table.
DOI: 10.15468/dl.xs9rxc
title: Occurrence Download

description: A dataset containing 1257 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Parthenium hysterophorus",
 "Country is Nepal",
 "HasCoordinate is true"
 ]
}

 The dataset includes 1257 records from 13 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0040462-250717081556266/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.xpfuy4
title: Occurrence Download

description: A dataset containing 51 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Parthenium hysterophorus",
 "Country is Mozambique",
 "HasCoordinate is true"
 ]
}

 The dataset includes 51 records from 5 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0040461-250717081556266/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.47e79f
title: Occurrence Download

description: A dataset containing 1273 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Podarcis muralis",
 "Country is United Kingdom of Great Britain and Northern Ireland",
 "HasCoordinate is true"
 ]
}

 The dataset includes 1273 records from 17 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0040463-250717081556266/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.te4a7e
title: Occurrence Download

description: A dataset containing 102 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is Germany",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 "TaxonKey is Maculinea rebeli"
 ]
}

 The dataset includes 102 records from 2 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0040464-250717081556266/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.b4rps3
title: Occurrence Download

description: A dataset containing 56 species occurrences available in GBIF matching the query:
{
 "and" : [
 "OccurrenceStatus is Present",
 "TaxonKey is Ottoschulzia cubensis"
 ]
}

 The dataset includes 56 records from 18 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0040466-250717081556266/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.fs4cya
title: Occurrence Download

description: A dataset containing 268 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Swertia cordata"
 ]
}

 The dataset includes 268 records from 36 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0040467-250717081556266/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.4yygb6
title: Occurrence Download

description: A dataset containing 939 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Parthenium hysterophorus",
 "Country is Pakistan",
 "HasCoordinate is true"
 ]
}

 The dataset includes 939 records from 10 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0040468-250717081556266/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.p4gz35
title: Occurrence Download

description: A dataset containing 1884342 species occurrences available in GBIF matching the query:
{
 "and" : [
 "HasGeospatialIssue is false",
 "HasCoordinate is true",
 "OccurrenceStatus is Present",
 "BasisOfRecord is one of (Human Observation, Machine Observation, Occurrence evidence, Observation)",
 "TaxonKey is one of (Larus marinus)",
 "Country is one of (Åland Islands, Albania, Andorra, Austria, Belarus, Belgium, Bosnia and Herzegovina, Bulgaria, Croatia, Czechia, Denmark, Estonia, Faroe Islands, Finland, France, Germany, Gibraltar, Greece, Guernsey, Holy See, Hungary, Iceland, Ireland, Isle of Man, Italy, Jersey, Latvia, Liechtenstein, Lithuania, Luxembourg, Malta, Moldova, Republic of, Monaco, Montenegro, Netherlands, North Macedonia, Norway, Poland, Portugal, Romania, Russian Federation, San Marino, Serbia, Slovakia, Slovenia, Spain, Svalbard and Jan Mayen, Sweden, Switzerland, Ukraine, United Kingdom of Great Britain and Northern Ireland)"
 ]
}

 The dataset includes 1884342 records from 611 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0040419-250717081556266/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.8c4r56
title: Occurrence Download

description: A dataset containing 29330 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Swertia perennis"
 ]
}

 The dataset includes 29330 records from 469 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0040465-250717081556266/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.6084/m9.figshare.29538170.v1
title: <i>Tmprss6</i> modulates radiation-induced liver injury through the hepcidin axis and PI3K/AKT pathway

description: Radiation-induced liver injury (RILI) poses a significant challenge in abdomino-pelvic tumor radiotherapy, adversely impacting normal liver tissues. This study explores the role of <i>Tmprss6</i>, a gene encoding Matriptase2, in acute RILI development and its impact on hepatocyte apoptosis. A RILI model was established using 30 Gy total liver irradiation in C57BL/6J mice. Expression of <i>Tmprss6</i> and hepcidin post radiation was detected by immunohistochemistry staining, Western blot and quantitative real-time PCR. <i>Tmprss6</i> knockout mice were established to demonstrate the contribution of <i>Tmprss6</i> to RILI. The molecular response within the liver after <i>Tmprss6</i> knockdown was investigated using Transcriptomics sequencing. Disruptions in the Matriptase2-hepcidin axis emerge post-total liver radiation, marked by decreased Matriptase2 levels and heightened hepcidin levels. <i>Tmprss6</i> knockout exacerbates RILI, evident in reduced mouse survival, increased liver damage, and elevated serum levels of aminotransferases. Additionally, <i>Tmprss6</i> deletion increases inflammatory cytokines and malondialdehyde level while diminishing liver antioxidant capacity. Gene expression profiling reveals shifts in inflammation, apoptosis, and p53 signaling pathways upon <i>Tmprss6</i> deletion. In vitro experiments, utilizing the AKT inhibitor AZD5363, demonstrate its effectiveness in reversing impediments caused by <i>Tmprss6</i> silencing post-radiation. AZD5363 effectively restores suppressed cell proliferation, mitigates heightened cell apoptosis, and counters the elevated p53 expression induced by <i>Tmprss6</i> depletion. This underscores the partial mediation of <i>Tmprss6</i>’s protective role through the PI3K-AKT signaling. This study unveils intricate mechanistic pathways activated by <i>Tmprss6</i> silencing, amplifying p53 expression, facilitating hepatocyte apoptosis, and accelerating RILI progression, which providing nuanced insights into the multifaceted involvement of <i>Tmprss6</i> in RILI.
DOI: 10.6084/m9.figshare.29538170
title: <i>Tmprss6</i> modulates radiation-induced liver injury through the hepcidin axis and PI3K/AKT pathway

description: Radiation-induced liver injury (RILI) poses a significant challenge in abdomino-pelvic tumor radiotherapy, adversely impacting normal liver tissues. This study explores the role of <i>Tmprss6</i>, a gene encoding Matriptase2, in acute RILI development and its impact on hepatocyte apoptosis. A RILI model was established using 30 Gy total liver irradiation in C57BL/6J mice. Expression of <i>Tmprss6</i> and hepcidin post radiation was detected by immunohistochemistry staining, Western blot and quantitative real-time PCR. <i>Tmprss6</i> knockout mice were established to demonstrate the contribution of <i>Tmprss6</i> to RILI. The molecular response within the liver after <i>Tmprss6</i> knockdown was investigated using Transcriptomics sequencing. Disruptions in the Matriptase2-hepcidin axis emerge post-total liver radiation, marked by decreased Matriptase2 levels and heightened hepcidin levels. <i>Tmprss6</i> knockout exacerbates RILI, evident in reduced mouse survival, increased liver damage, and elevated serum levels of aminotransferases. Additionally, <i>Tmprss6</i> deletion increases inflammatory cytokines and malondialdehyde level while diminishing liver antioxidant capacity. Gene expression profiling reveals shifts in inflammation, apoptosis, and p53 signaling pathways upon <i>Tmprss6</i> deletion. In vitro experiments, utilizing the AKT inhibitor AZD5363, demonstrate its effectiveness in reversing impediments caused by <i>Tmprss6</i> silencing post-radiation. AZD5363 effectively restores suppressed cell proliferation, mitigates heightened cell apoptosis, and counters the elevated p53 expression induced by <i>Tmprss6</i> depletion. This underscores the partial mediation of <i>Tmprss6</i>’s protective role through the PI3K-AKT signaling. This study unveils intricate mechanistic pathways activated by <i>Tmprss6</i> silencing, amplifying p53 expression, facilitating hepatocyte apoptosis, and accelerating RILI progression, which providing nuanced insights into the multifaceted involvement of <i>Tmprss6</i> in RILI.
DOI: 10.6084/m9.figshare.29371257
title: Radiobiological mechanisms of radium-223 dichloride: a nonclinical study

description: This study aimed to elucidate the radiobiological mechanisms of radium-223 dichloride ([<sup>223</sup>Ra]RaCl<sub>2</sub>)—an FDA-approved agent for metastatic castration-resistant prostate cancer—by investigating its in vitro and in vivo toxic effects. Using both the CCK8 and clonogenic assays, our in vitro experiments evaluated the inhibition of cell proliferation in response to variations in applied activity and exposure duration in human cancer cell lines (MDA-MB-231, BxPC3, A549, and PC3) as well as in rat pancreatic cancer cells (AR42J). Molecular analyses utilizing SDS-PAGE characterized the activation of specific cell death pathways. Additionally, an in vivo investigation employing intravenous administration further examined the systemic toxicity of [<sup>223</sup>Ra]RaCl<sub>2</sub> by monitoring animal mortality, body weight, and hematological parameters following treatment with varying activity levels (74, 148, and 222 kBq/head). [<sup>223</sup>Ra]RaCl<sub>2</sub> significantly inhibited cell proliferation in an applied activity- and time-dependent manner in human cancer cell lines, whereas AR42J cells showed relative resistance. Molecular findings revealed that BxPC3 cells underwent apoptosis via caspase-3 cleavage; PC3 cells experienced pyroptosis marked by gasdermin E (GSDME) activation and caspase-7 cleavage; and MDA-MB-231 cells exhibited enhanced PARP-1 activation indicative of DNA double-strand breaks. In vivo, treated animals demonstrated significant differences in mortality, body weight, and hematological parameters compared to controls, mirroring myelosuppressive effects typical of radiotherapy. The findings provide critical insights into the differential cytotoxic mechanisms of [<sup>223</sup>Ra]RaCl<sub>2</sub> across various cancer cell types and highlight its systemic toxicity in vivo. This improved understanding may facilitate the development of safer and more effective therapeutic radiopharmaceuticals based on [<sup>223</sup>Ra]RaCl<sub>2</sub>.
DOI: 10.6084/m9.figshare.29371257.v1
title: Radiobiological mechanisms of radium-223 dichloride: a nonclinical study

description: This study aimed to elucidate the radiobiological mechanisms of radium-223 dichloride ([<sup>223</sup>Ra]RaCl<sub>2</sub>)—an FDA-approved agent for metastatic castration-resistant prostate cancer—by investigating its in vitro and in vivo toxic effects. Using both the CCK8 and clonogenic assays, our in vitro experiments evaluated the inhibition of cell proliferation in response to variations in applied activity and exposure duration in human cancer cell lines (MDA-MB-231, BxPC3, A549, and PC3) as well as in rat pancreatic cancer cells (AR42J). Molecular analyses utilizing SDS-PAGE characterized the activation of specific cell death pathways. Additionally, an in vivo investigation employing intravenous administration further examined the systemic toxicity of [<sup>223</sup>Ra]RaCl<sub>2</sub> by monitoring animal mortality, body weight, and hematological parameters following treatment with varying activity levels (74, 148, and 222 kBq/head). [<sup>223</sup>Ra]RaCl<sub>2</sub> significantly inhibited cell proliferation in an applied activity- and time-dependent manner in human cancer cell lines, whereas AR42J cells showed relative resistance. Molecular findings revealed that BxPC3 cells underwent apoptosis via caspase-3 cleavage; PC3 cells experienced pyroptosis marked by gasdermin E (GSDME) activation and caspase-7 cleavage; and MDA-MB-231 cells exhibited enhanced PARP-1 activation indicative of DNA double-strand breaks. In vivo, treated animals demonstrated significant differences in mortality, body weight, and hematological parameters compared to controls, mirroring myelosuppressive effects typical of radiotherapy. The findings provide critical insights into the differential cytotoxic mechanisms of [<sup>223</sup>Ra]RaCl<sub>2</sub> across various cancer cell types and highlight its systemic toxicity in vivo. This improved understanding may facilitate the development of safer and more effective therapeutic radiopharmaceuticals based on [<sup>223</sup>Ra]RaCl<sub>2</sub>.
DOI: 10.15468/dl.vt59bu
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Cuscuta pentagona",
 "Country is Kenya",
 "HasCoordinate is true"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0040469-250717081556266/datasets/export for details.
DOI: 10.6084/m9.figshare.29477982.v1
title: Exploration of pyrazole-based pyridine-4-carbohydrazide derivatives as drug-resistant <i>Mtb</i> agents: design, synthesis, biological evaluation, and <i>in-silico</i> studies

description: Development of new effective drugs against multidrug resistant <i>Mycobacterium tuberculosis</i> is the need of the hour to combat tuberculosis (TB) disease. Pyridine-4-carbohydrazide and substituted pyrazole aldehydes were used to synthesize target molecules (6a-r) which were evaluated against H<sub>37</sub>Rv and drug-resistant TB strains. Time kill kinetics assay was performed to check bactericidal/bacteriostatic effect, molecular docking, dynamics simulation over 100 ns was performed against enoyl acyl carrier protein reductase (InhA) along with QSAR, ADMET profile prediction. All compounds displayed excellent MICs in the range of 0.125–16 <i>µ</i>g/mL. The most potent compound, 6q, with an MIC of 0.125 <i>µ</i>g/mL showed bactericidal effect and was effective on ethambutol and streptomycin resistant <i>Mtb</i> strains with an MIC of 0.03 <i>µ</i>g/mL and rifampicin resistant <i>Mtb</i> strain with an MIC of 0.25 <i>µ</i>g/mL. The pyrazole clubbed with pyridine-4-carbohydrazide is a potential scaffold for further exploration as anti-TB agent.
DOI: 10.6084/m9.figshare.29477982
title: Exploration of pyrazole-based pyridine-4-carbohydrazide derivatives as drug-resistant <i>Mtb</i> agents: design, synthesis, biological evaluation, and <i>in-silico</i> studies

description: Development of new effective drugs against multidrug resistant <i>Mycobacterium tuberculosis</i> is the need of the hour to combat tuberculosis (TB) disease. Pyridine-4-carbohydrazide and substituted pyrazole aldehydes were used to synthesize target molecules (6a-r) which were evaluated against H<sub>37</sub>Rv and drug-resistant TB strains. Time kill kinetics assay was performed to check bactericidal/bacteriostatic effect, molecular docking, dynamics simulation over 100 ns was performed against enoyl acyl carrier protein reductase (InhA) along with QSAR, ADMET profile prediction. All compounds displayed excellent MICs in the range of 0.125–16 <i>µ</i>g/mL. The most potent compound, 6q, with an MIC of 0.125 <i>µ</i>g/mL showed bactericidal effect and was effective on ethambutol and streptomycin resistant <i>Mtb</i> strains with an MIC of 0.03 <i>µ</i>g/mL and rifampicin resistant <i>Mtb</i> strain with an MIC of 0.25 <i>µ</i>g/mL. The pyrazole clubbed with pyridine-4-carbohydrazide is a potential scaffold for further exploration as anti-TB agent.
DOI: 10.6084/m9.figshare.29436136
title: Discovery and evaluation of novel pyrrole/thiophene chalcone urea EGFR inhibitors via biological and docking studies

description: This study aimed to synthesize novel chalcone-urea derivatives and evaluate their anticancer potential through antiproliferative, apoptotic, and epidermal growth factor receptor (EGFR) inhibitory activities, supported by molecular modeling. Thirty-three chalcone-urea derivatives were synthesized in two series: pyrrole-chalcone ureas (<b>4a</b>–<b>4r</b>) and thiophene-chalcone ureas (<b>5a</b>–<b>5p</b>). Compounds were characterized using<sup>1</sup> H NMR, <sup>13</sup> C NMR, and mass spectrometry. Their antiproliferative effects were assessed against renal adenocarcinoma (769P), lung carcinoma (A549), colorectal adenocarcinoma (HT-29), and healthy kidney (HEK-293) cell lines. Selected compounds were further evaluated for EGFR inhibition, apoptotic activity, and cell cycle arrest. Molecular docking was performed to predict binding interactions with wild-type human EGFR. Compounds <b>4e</b>, <b>4f</b>, and <b>4g</b> (pyrrole series) showed strong cytotoxicity against A549 and HT-29, while <b>5b</b>, <b>5c</b>, and <b>5d</b> (thiophene series) were effective on 769P. Compound <b>5c</b> exhibited the highest EGFR inhibition (IC₅₀ = 1 nM), potent apoptotic induction, and cell cycle arrest at the S phase in A549 cells. Docking studies confirmed favorable binding of <b>4r</b>, <b>5c</b>, and <b>5d</b> within the EGFR active site. Several chalcone-urea derivatives demonstrated potent anticancer properties, with compound 5c emerging as a promising EGFR inhibitor with strong cytotoxic and pro-apoptotic effects.