cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.28624617
title: The importance of the cumulation of risk factors for antepartum depression

description: Pregnancy is a period of heightened vulnerability to mental health problems. This pilot study aims to investigate the association between psychosocial and obstetric risk factors and the onset of depressive and anxious symptoms during pregnancy, with a focus on cumulative risks. Conducted at Ghent University Hospital in Belgium, this prospective observational study involved 378 pregnant women. Participants received a semi-standardized psychosocial assessment at 16 weeks to evaluate potential risk factors, followed by stepped screening protocol for depressive and anxious symptoms at 20 weeks. Due to significant overlap, the analysis focused solely on depressive symptoms. Depressive symptoms were identified in 5.5% of participants with a score ≥ 13 on the Edinburgh Depression Scale. Key psychosocial risk factors that increase the risk of antepartum depression include a history of mental health issues, especially depression (Fisher’s exact test (FET), <i>p</i> = .018), experiences of physical (FET, <i>p</i> = .007) or emotional (FET, <i>p</i> = .008) violence, lack of social support (FET, <i>p</i> = .014), and unplanned pregnancy (FET, <i>p</i> = .008). No significant association was found between obstetric factors and depressive symptoms. The study highlights that the accumulation of psychosocial risk factors significantly elevates the risk of depression (Kendall’s τ = 0.22, <i>p</i> &lt; .001). These findings underscore the necessity of comprehensive psychosocial assessments in pregnant women, offering deeper insights than mere screenings for depression and anxiety. Recognizing and quantifying these risk factors facilitates targeted interventions. Employing a cumulative risk index effectively identifies women at heightened risk of mental health problems.
DOI: 10.6084/m9.figshare.28624617.v1
title: The importance of the cumulation of risk factors for antepartum depression

description: Pregnancy is a period of heightened vulnerability to mental health problems. This pilot study aims to investigate the association between psychosocial and obstetric risk factors and the onset of depressive and anxious symptoms during pregnancy, with a focus on cumulative risks. Conducted at Ghent University Hospital in Belgium, this prospective observational study involved 378 pregnant women. Participants received a semi-standardized psychosocial assessment at 16 weeks to evaluate potential risk factors, followed by stepped screening protocol for depressive and anxious symptoms at 20 weeks. Due to significant overlap, the analysis focused solely on depressive symptoms. Depressive symptoms were identified in 5.5% of participants with a score ≥ 13 on the Edinburgh Depression Scale. Key psychosocial risk factors that increase the risk of antepartum depression include a history of mental health issues, especially depression (Fisher’s exact test (FET), <i>p</i> = .018), experiences of physical (FET, <i>p</i> = .007) or emotional (FET, <i>p</i> = .008) violence, lack of social support (FET, <i>p</i> = .014), and unplanned pregnancy (FET, <i>p</i> = .008). No significant association was found between obstetric factors and depressive symptoms. The study highlights that the accumulation of psychosocial risk factors significantly elevates the risk of depression (Kendall’s τ = 0.22, <i>p</i> &lt; .001). These findings underscore the necessity of comprehensive psychosocial assessments in pregnant women, offering deeper insights than mere screenings for depression and anxiety. Recognizing and quantifying these risk factors facilitates targeted interventions. Employing a cumulative risk index effectively identifies women at heightened risk of mental health problems.
DOI: 10.21233/gag6-4t26
title: Why Lake A pollen surface sample dataset

description: Raw data for the Why Lake A pollen surface sample dataset submitted to the Neotoma Paleoecology Database. Data is available through the landing page in JSON format. The landing page referenced by the DOI also contains links to publications and a map-based viewer for the dataset. The Neotoma Paleoecology Database maintains a homepage at https://www.neotomadb.org.
DOI: 10.6084/m9.figshare.1454524
title: Identification of a lung cancer cell line deficient in atg7-dependent autophagy

description: Autophagy is a major cellular process for bulk degradation of proteins and organelles in order to maintain metabolic homeostasis, and it represents an emerging target area for cancer. Initially proposed to be a cancer-restricting process for tumor initiation, recent studies suggest that autophagy can also promote cell survival in established tumors. <i>ATG7</i> is an essential autophagy gene that encodes the E1 enzyme necessary for the lipidation of the LC3 family of ubiquitin-like proteins and autophagosome formation. In this study we identified a rare case of a cancer cell line, H1650 lung adenocarcinoma, which has lost ATG7 expression due to a focal biallelic deletion within the <i>ATG7</i> locus. These cells displayed no evidence of ATG7 pathway activity; however, reconstituting the cells with wild-type ATG7 restored both LC3 lipidation and downstream autophagic consumption of autophagy substrates such as the SQSTM1/p62 protein. We characterized several phenotypes reported to be influenced by autophagy, and observed an ATG7-dependent increase in cell growth and clearance of proteasome-inhibitor induced protein aggregates. Cellular changes in mitochondrial metabolism or response to nutrient starvation were unaffected by ATG7 expression. In addition, parental H1650 cells that lacked ATG7 were still able to consume autophagy substrates SQSTM1, NBR1 and TAX1BP1 via a bafilomycin A<sub>1</sub>-sensitive pathway, suggesting that these proteins were not exclusively degraded by autophagy. Overall, these findings highlight a unique outlier instance of complete loss of ATG7-dependent autophagy in a cancer cell line. The H1650 cell line may be a useful system for future studies to further understand the role of autophagy in tumorigenesis and potential redundant pathways that allow cells to circumvent the loss of ATG7-dependent autophagy in cancer.
DOI: 10.6084/m9.figshare.1454524.v2
title: Identification of a lung cancer cell line deficient in atg7-dependent autophagy

description: Autophagy is a major cellular process for bulk degradation of proteins and organelles in order to maintain metabolic homeostasis, and it represents an emerging target area for cancer. Initially proposed to be a cancer-restricting process for tumor initiation, recent studies suggest that autophagy can also promote cell survival in established tumors. <i>ATG7</i> is an essential autophagy gene that encodes the E1 enzyme necessary for the lipidation of the LC3 family of ubiquitin-like proteins and autophagosome formation. In this study we identified a rare case of a cancer cell line, H1650 lung adenocarcinoma, which has lost ATG7 expression due to a focal biallelic deletion within the <i>ATG7</i> locus. These cells displayed no evidence of ATG7 pathway activity; however, reconstituting the cells with wild-type ATG7 restored both LC3 lipidation and downstream autophagic consumption of autophagy substrates such as the SQSTM1/p62 protein. We characterized several phenotypes reported to be influenced by autophagy, and observed an ATG7-dependent increase in cell growth and clearance of proteasome-inhibitor induced protein aggregates. Cellular changes in mitochondrial metabolism or response to nutrient starvation were unaffected by ATG7 expression. In addition, parental H1650 cells that lacked ATG7 were still able to consume autophagy substrates SQSTM1, NBR1 and TAX1BP1 via a bafilomycin A<sub>1</sub>-sensitive pathway, suggesting that these proteins were not exclusively degraded by autophagy. Overall, these findings highlight a unique outlier instance of complete loss of ATG7-dependent autophagy in a cancer cell line. The H1650 cell line may be a useful system for future studies to further understand the role of autophagy in tumorigenesis and potential redundant pathways that allow cells to circumvent the loss of ATG7-dependent autophagy in cancer.
DOI: 10.6084/m9.figshare.1454524.v1
title: Identification of a lung cancer cell line deficient in atg7-dependent autophagy

description: ABSTRACTAutophagy is a major cellular process for bulk degradation of proteins and organelles in order to maintain metabolic homeostasis, and it represents an emerging target area for cancer. Initially proposed to be a cancer-restricting process for tumor initiation, recent studies suggest that autophagy can also promote cell survival in established tumors. <i>ATG7</i> is an essential autophagy gene that encodes the E1 enzyme necessary for the lipidation of the LC3 family of ubiquitin-like proteins and autophagosome formation. In this study we identified a rare case of a cancer cell line, H1650 lung adenocarcinoma, which has lost ATG7 expression due to a focal biallelic deletion within the <i>ATG7</i> locus. These cells displayed no evidence of ATG7 pathway activity; however, reconstituting the cells with wild-type ATG7 restored both LC3 lipidation and downstream autophagic consumption of autophagy substrates such as the SQSTM1/p62 protein. We characterized several phenotypes reported to be influenced by autophagy, and observed an ATG7-dependent increase in cell growth and clearance of proteasome-inhibitor induced protein aggregates. Cellular changes in mitochondrial metabolism or response to nutrient starvation were unaffected by ATG7 expression. In addition, parental H1650 cells that lacked ATG7 were still able to consume autophagy substrates SQSTM1, NBR1 and TAX1BP1 via a bafilomycin A<sub>1</sub>-sensitive pathway, suggesting that these proteins were not exclusively degraded by autophagy. Overall, these findings highlight a unique outlier instance of complete loss of ATG7-dependent autophagy in a cancer cell line. The H1650 cell line may be a useful system for future studies to further understand the role of autophagy in tumorigenesis and potential redundant pathways that allow cells to circumvent the loss of ATG7-dependent autophagy in cancer.
DOI: 10.21233/qw5r-zt44
title: Jasper (Stauffer Elephant 26) vertebrate fauna dataset

description: Raw data for the Jasper (Stauffer Elephant 26) vertebrate fauna dataset submitted to the Neotoma Paleoecology Database. Data is available through the landing page in JSON format. The landing page referenced by the DOI also contains links to publications and a map-based viewer for the dataset. The Neotoma Paleoecology Database maintains a homepage at https://www.neotomadb.org.
DOI: 10.21233/z1gm-9r58
title: LDDsite36 ostracode surface sample dataset

description: Raw data for the LDDsite36 ostracode surface sample dataset submitted to the Neotoma Paleoecology Database. Data is available through the landing page in JSON format. The landing page referenced by the DOI also contains links to publications and a map-based viewer for the dataset. The Neotoma Paleoecology Database maintains a homepage at https://www.neotomadb.org.
DOI: 10.6084/m9.figshare.28449123
title: Evaluating PEMF vagus nerve stimulation through neck application: A randomized placebo study with volunteers

description: This study investigates the effects of pulsed electromagnetic field (PEMF) therapy on vagus nerve stimulation through non-invasive neck applications. Exploring the efficacy of PEMF across different frequencies (6 hz, 16 hz, and 32 hz), this double-blind placebo-controlled trial included 485 volunteers to assess its impact on autonomic nervous system functions, particularly targeting sleep disturbances and anxiety. Results demonstrated significant improvements in sleep quality and reduction in anxiety levels, especially notable at 16 hz. These findings suggest that PEMF therapy, by modulating autonomic activity, offers a beneficial non-pharmacological treatment option for related disorders. The study investigates the impact of pulsed electromagnetic field (PEMF) therapy on the vagus nerve through non-invasive applications on the neck, focusing on its role in autonomic nervous system functions. It specifically explores the influence of different PEMF frequencies to treat sleep disturbances and anxiety among volunteers. This research used a double-blind, placebo-controlled trial format involving 485 volunteers to assess the efficacy of PEMF therapy at varying frequencies (6 hz, 16 hz, 32 hz). Measurements were conducted to monitor changes in sleep quality and anxiety levels, utilizing questionnaires.Findings indicate significant improvements in sleep quality and reductions in anxiety levels, particularly pronounced at the 16 hz stimulation frequency. The study shows that different frequencies may influence the autonomic nervous system distinctly, showcasing the 16 hz frequency’s notable efficacy in modulating autonomic activities beneficially, while 6 hz suggests a contra placebo effect. PEMF therapy serves as a non-pharmacological alternative for managing conditions like sleep disturbances and anxiety through vagus nerve stimulation. The research highlights the therapeutic potential of specific PEMF frequencies in improving autonomic functions, suggesting further exploration into frequency-specific treatments that could prove beneficial.
DOI: 10.6084/m9.figshare.28449123.v1
title: Evaluating PEMF vagus nerve stimulation through neck application: A randomized placebo study with volunteers

description: This study investigates the effects of pulsed electromagnetic field (PEMF) therapy on vagus nerve stimulation through non-invasive neck applications. Exploring the efficacy of PEMF across different frequencies (6 hz, 16 hz, and 32 hz), this double-blind placebo-controlled trial included 485 volunteers to assess its impact on autonomic nervous system functions, particularly targeting sleep disturbances and anxiety. Results demonstrated significant improvements in sleep quality and reduction in anxiety levels, especially notable at 16 hz. These findings suggest that PEMF therapy, by modulating autonomic activity, offers a beneficial non-pharmacological treatment option for related disorders. The study investigates the impact of pulsed electromagnetic field (PEMF) therapy on the vagus nerve through non-invasive applications on the neck, focusing on its role in autonomic nervous system functions. It specifically explores the influence of different PEMF frequencies to treat sleep disturbances and anxiety among volunteers. This research used a double-blind, placebo-controlled trial format involving 485 volunteers to assess the efficacy of PEMF therapy at varying frequencies (6 hz, 16 hz, 32 hz). Measurements were conducted to monitor changes in sleep quality and anxiety levels, utilizing questionnaires.Findings indicate significant improvements in sleep quality and reductions in anxiety levels, particularly pronounced at the 16 hz stimulation frequency. The study shows that different frequencies may influence the autonomic nervous system distinctly, showcasing the 16 hz frequency’s notable efficacy in modulating autonomic activities beneficially, while 6 hz suggests a contra placebo effect. PEMF therapy serves as a non-pharmacological alternative for managing conditions like sleep disturbances and anxiety through vagus nerve stimulation. The research highlights the therapeutic potential of specific PEMF frequencies in improving autonomic functions, suggesting further exploration into frequency-specific treatments that could prove beneficial.
DOI: 10.21233/xf9q-y866
title: Lake Morris water chemistry dataset

description: Raw data for the Lake Morris water chemistry dataset submitted to the Neotoma Paleoecology Database. Data is available through the landing page in JSON format. The landing page referenced by the DOI also contains links to publications and a map-based viewer for the dataset. The Neotoma Paleoecology Database maintains a homepage at https://www.neotomadb.org.
DOI: 10.15468/dl.d89ky8
title: Occurrence Download

description: A dataset containing 19008 species occurrences available in GBIF matching the query:
{
 "and" : [
 "OccurrenceStatus is Present",
 "TaxonKey is Streptopelia decaocto (Frivaldszky, 1838)",
 "Year 1998-1999"
 ]
}

 The dataset includes 19008 records from 163 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0026699-250426092105405/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.21233/7khy-6n67
title: Winslow vertebrate fauna dataset

description: Raw data for the Winslow vertebrate fauna dataset submitted to the Neotoma Paleoecology Database. Data is available through the landing page in JSON format. The landing page referenced by the DOI also contains links to publications and a map-based viewer for the dataset. The Neotoma Paleoecology Database maintains a homepage at https://www.neotomadb.org.
DOI: 10.21233/31ah-kk77
title: Dune Lake pollen dataset

description: Raw data for the Dune Lake pollen dataset submitted to the Neotoma Paleoecology Database. Data is available through the landing page in JSON format. The landing page referenced by the DOI also contains links to publications and a map-based viewer for the dataset. The Neotoma Paleoecology Database maintains a homepage at https://www.neotomadb.org.
DOI: 10.21233/qzs1-b198
title: Lake Apopka diatom dataset

description: Raw data for the Lake Apopka diatom dataset submitted to the Neotoma Paleoecology Database. Data is available through the landing page in JSON format. The landing page referenced by the DOI also contains links to publications and a map-based viewer for the dataset. The Neotoma Paleoecology Database maintains a homepage at https://www.neotomadb.org.
DOI: 10.15468/dd.gr2kd9
title: Distribution records of Electrona antarctica

description: These records of Electrona antarctica were downloaded from GBIF on 2019-09-11.
DOI: 10.21233/t66v-3852
title: Larix laricina Site 4 plant macrofossil dataset

description: Raw data for the Larix laricina Site 4 plant macrofossil dataset submitted to the Neotoma Paleoecology Database. Data is available through the landing page in JSON format. The landing page referenced by the DOI also contains links to publications and a map-based viewer for the dataset. The Neotoma Paleoecology Database maintains a homepage at https://www.neotomadb.org.
DOI: 10.21233/wdcc-pj62
title: Paddon [DiLg-1] vertebrate fauna dataset

description: Raw data for the Paddon [DiLg-1] vertebrate fauna dataset submitted to the Neotoma Paleoecology Database. Data is available through the landing page in JSON format. The landing page referenced by the DOI also contains links to publications and a map-based viewer for the dataset. The Neotoma Paleoecology Database maintains a homepage at https://www.neotomadb.org.
DOI: 10.15468/dl.utaukz
title: Occurrence Download

description: A dataset containing 9630 species occurrences available in GBIF matching the query:
{
 "DatasetKey" : [
 "is Colecciones del Herbario QCA, Pontificia Universidad Católica del Ecuador"
 ]
}

 The dataset includes 9630 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0026700-250426092105405/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.21233/8gfe-ys04
title: Opeongo Lake/South Arm water chemistry dataset

description: Raw data for the Opeongo Lake/South Arm water chemistry dataset submitted to the Neotoma Paleoecology Database. Data is available through the landing page in JSON format. The landing page referenced by the DOI also contains links to publications and a map-based viewer for the dataset. The Neotoma Paleoecology Database maintains a homepage at https://www.neotomadb.org.
DOI: 10.21233/a5xh-4h94
title: Crooked Lake water chemistry dataset

description: Raw data for the Crooked Lake water chemistry dataset submitted to the Neotoma Paleoecology Database. Data is available through the landing page in JSON format. The landing page referenced by the DOI also contains links to publications and a map-based viewer for the dataset. The Neotoma Paleoecology Database maintains a homepage at https://www.neotomadb.org.
DOI: 10.6084/m9.figshare.28335305
title: Effects of dietary processed former foodstuffs on slaughter performance and meat quality in broilers

description: This study assessed the effects of incorporating commercially processed former foodstuffs (cFF) as substitutes for corn, soybean meal and soybean oil in broilers’ diet on slaughter performance, physicochemical properties and meat sensory attributes. Two hundred and one-day-old male chicks (ROSS-308) were divided into four dietary groups with increasing levels of cFF (0, 6.25%, 12.5% and 25%) named cFF0, cFF6.25, cFF12.5 and cFF25, respectively. On d 33, 25 chickens per dietary group were slaughtered for analyses. Carcase traits were similar across groups, except for a decrease in gizzard yield in cFF25 group (<i>p</i> = .008). Shear force, cooking loss and drip loss were unaffected by the diet. Meat pH decreased linearly in both breast and thigh muscles, and the thigh muscle yellowness index increased (<i>p</i> &lt; .05). Breast crude protein (CP) decreased, while thigh CP and breast ether extract increased as the cFF inclusion level rose (<i>p</i> &lt; .05). The fatty acid (FA) content of breast and thigh meat showed a linear increase in monounsaturated FA, with thigh meat also exhibiting a linear increase in saturated FA (SFA). Conversely, polyunsaturated FA (PUFA) and the PUFA to SFA ratio decreased with increasing cFF levels (<i>p</i> &lt; .05). Lipid oxidation levels remained unchanged across groups. Sensory analysis revealed no differences in overall acceptability or liking among groups, although two sensory attributes (sour and hard) resulted as discriminating factors (<i>p</i> &lt; .05). Overall, cFF inclusion did not affect meat quality, oxidative stability or consumer perception but altered the FA composition, suggesting the need of further investigation to assess the optimal inclusion level. Commercially processed former foodstuffs (cFF) in broiler diets did not impact carcase traits or meat quality.Inclusion of cFF in broiler diets reduced gizzard yield, especially at 25% inclusion.Inclusion of cFF reduced polyunsaturated fatty acids to saturated fatty acids ratio in chicken meat, while increasing the <i>n</i>-6 to <i>n</i>-3 ratio.Inclusion of cFF did not affect the sensory attributes or overall liking of the final product. Commercially processed former foodstuffs (cFF) in broiler diets did not impact carcase traits or meat quality. Inclusion of cFF in broiler diets reduced gizzard yield, especially at 25% inclusion. Inclusion of cFF reduced polyunsaturated fatty acids to saturated fatty acids ratio in chicken meat, while increasing the <i>n</i>-6 to <i>n</i>-3 ratio. Inclusion of cFF did not affect the sensory attributes or overall liking of the final product.