cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.12091173
title: Supplementary Material for: Patterns of Late Relapse after Allogeneic Hematopoietic Stem Cell Transplantation in Patients with T-Cell Prolymphocytic Leukemia

description: Initial treatment with the monoclonal anti-CD52 antibody alemtuzumab induces responses in the majority of patients with T-cell prolymphocytic leukemia (T-PLL). In eligible patients, allogeneic hematopoietic stem cell transplantation (allo-HSCT) is an option to consolidate hematological remissions. Here, we report our experience with 10 patients who received allo-HSCT against T-PLL. Notably, 3 patients with complete remission at transplantation and durable full-donor chimerism relapsed at months 12, 59, and 84 after transplantation, respectively. This relapse was associated with rapid progressive leukemia in 1 patient and extralymphatic lymphoma growth in the other 2. Despite CD52 positivity at relapse, alemtuzumab retreatment, donor lymphocyte infusions, and/or chemotherapy including salvage therapy, allo-HSCT yielded a transient partial response, only. Alemtuzumab induction and consolidative allo-HSCT enabled prolonged disease-free survival in these patients but failed to procure cure.
DOI: 10.6084/m9.figshare.12091173.v1
title: Supplementary Material for: Patterns of Late Relapse after Allogeneic Hematopoietic Stem Cell Transplantation in Patients with T-Cell Prolymphocytic Leukemia

description: Initial treatment with the monoclonal anti-CD52 antibody alemtuzumab induces responses in the majority of patients with T-cell prolymphocytic leukemia (T-PLL). In eligible patients, allogeneic hematopoietic stem cell transplantation (allo-HSCT) is an option to consolidate hematological remissions. Here, we report our experience with 10 patients who received allo-HSCT against T-PLL. Notably, 3 patients with complete remission at transplantation and durable full-donor chimerism relapsed at months 12, 59, and 84 after transplantation, respectively. This relapse was associated with rapid progressive leukemia in 1 patient and extralymphatic lymphoma growth in the other 2. Despite CD52 positivity at relapse, alemtuzumab retreatment, donor lymphocyte infusions, and/or chemotherapy including salvage therapy, allo-HSCT yielded a transient partial response, only. Alemtuzumab induction and consolidative allo-HSCT enabled prolonged disease-free survival in these patients but failed to procure cure.
DOI: 10.6084/m9.figshare.12091155
title: Copy of round 1& 2 (4).xlsx

description: The result of the first and second round of Delphi.
DOI: 10.6084/m9.figshare.12091089
title: Supplementary Material for: Ambulatory Blood Pressure Trajectories and Blood Pressure Variability in Diabetic and Non-Diabetic Chronic Kidney Disease

description: <b><i>Background:</i></b> Diabetic kidney disease is the leading cause of end-stage renal disease worldwide. Whether diabetes mellitus (DM) is an additional factor leading to elevated blood pressure (BP) levels and BP variability (BPV) in patients with chronic kidney disease (CKD) is unknown. This study aimed to compare ambulatory BP levels, BP trends and BPV in diabetic and non-diabetic patients with CKD. <b><i>Methods:</i></b> This study included 48 diabetic and 48 non-diabetic adult patients (&gt;18 years) with CKD (estimated glomerular filtration rate [eGFR] &lt;90 and ≥15 mL/min/1.73 m<sup>2</sup>), matched in a 1:1 ratio for age, sex and eGFR within each CKD stage (2, 3a, 3b and 4). All patients underwent 24-h ambulatory BP measurement with the Mobil-O-graph device. To evaluate the effect of DM and time on the trajectories of 24-h BP levels, we performed two-way mixed ANOVA analysis for repeated measurements using hourly means. BPV was calculated with validated formulas. <b><i>Results:</i></b> In total, patients with DM had significantly higher 24-h systolic BP (SBP; 132.13 ± 10.71 vs. 124.16 ± 11.45; <i>p</i> = 0.001) and pulse pressure (PP; 57.1 ± 9.6 vs. 49.5 ± 10.9; <i>p</i> &lt; 0.001), but similar 24-h diastolic BP (DBP; 75.00 ± 8.43 vs. 74.62 ± 6.86 mm Hg; <i>p</i> = 0.809) compared to patients without DM. A similar trend was evident across all CKD stages. The effect of DM on BP trajectories during the recording period was significant for SBP (<i>F</i> = 18.766, <i>p</i> &lt; 0.001, partial <i>η</i><sup>2</sup> = 0.261) and marginally significant for DBP (<i>F</i> = 3.782, <i>p</i> = 0.057, partial <i>η</i><sup>2</sup> = 0.067). Twenty-four hour SBP SD, weighted SD (wSD) and average real variability (ARV; 10.94 ± 2.75 vs. 9.46 ± 2.10; <i>p</i> = 0.004), as well as 24 h DBP SD, wSD, coefficient of variation (CV) and ARV (8.23 ± 2.10 vs. 7.10 ± 1.33; <i>p</i> = 0.002) were significantly higher in diabetic compared to non-diabetic CKD patients. <b><i>Conclusions:</i></b> Ambulatory SBP and PP levels are higher and SBP-profile is different in patients with diabetic compared to those with non-diabetic CKD. Systolic and diastolic BPV are also higher in diabetics. These findings may signify a higher cardiovascular risk for patients with both DM and CKD compared to patients with CKD alone, through higher BP levels and BPV.
DOI: 10.6084/m9.figshare.12091077
title: Genome assembly and gene annotation of Peltaster fructicola

description: The datasets of genome assembly and gene annotation of Peltaster fructicola<br>
DOI: 10.6084/m9.figshare.12091089.v1
title: Supplementary Material for: Ambulatory Blood Pressure Trajectories and Blood Pressure Variability in Diabetic and Non-Diabetic Chronic Kidney Disease

description: <b><i>Background:</i></b> Diabetic kidney disease is the leading cause of end-stage renal disease worldwide. Whether diabetes mellitus (DM) is an additional factor leading to elevated blood pressure (BP) levels and BP variability (BPV) in patients with chronic kidney disease (CKD) is unknown. This study aimed to compare ambulatory BP levels, BP trends and BPV in diabetic and non-diabetic patients with CKD. <b><i>Methods:</i></b> This study included 48 diabetic and 48 non-diabetic adult patients (&gt;18 years) with CKD (estimated glomerular filtration rate [eGFR] &lt;90 and ≥15 mL/min/1.73 m<sup>2</sup>), matched in a 1:1 ratio for age, sex and eGFR within each CKD stage (2, 3a, 3b and 4). All patients underwent 24-h ambulatory BP measurement with the Mobil-O-graph device. To evaluate the effect of DM and time on the trajectories of 24-h BP levels, we performed two-way mixed ANOVA analysis for repeated measurements using hourly means. BPV was calculated with validated formulas. <b><i>Results:</i></b> In total, patients with DM had significantly higher 24-h systolic BP (SBP; 132.13 ± 10.71 vs. 124.16 ± 11.45; <i>p</i> = 0.001) and pulse pressure (PP; 57.1 ± 9.6 vs. 49.5 ± 10.9; <i>p</i> &lt; 0.001), but similar 24-h diastolic BP (DBP; 75.00 ± 8.43 vs. 74.62 ± 6.86 mm Hg; <i>p</i> = 0.809) compared to patients without DM. A similar trend was evident across all CKD stages. The effect of DM on BP trajectories during the recording period was significant for SBP (<i>F</i> = 18.766, <i>p</i> &lt; 0.001, partial <i>η</i><sup>2</sup> = 0.261) and marginally significant for DBP (<i>F</i> = 3.782, <i>p</i> = 0.057, partial <i>η</i><sup>2</sup> = 0.067). Twenty-four hour SBP SD, weighted SD (wSD) and average real variability (ARV; 10.94 ± 2.75 vs. 9.46 ± 2.10; <i>p</i> = 0.004), as well as 24 h DBP SD, wSD, coefficient of variation (CV) and ARV (8.23 ± 2.10 vs. 7.10 ± 1.33; <i>p</i> = 0.002) were significantly higher in diabetic compared to non-diabetic CKD patients. <b><i>Conclusions:</i></b> Ambulatory SBP and PP levels are higher and SBP-profile is different in patients with diabetic compared to those with non-diabetic CKD. Systolic and diastolic BPV are also higher in diabetics. These findings may signify a higher cardiovascular risk for patients with both DM and CKD compared to patients with CKD alone, through higher BP levels and BPV.
DOI: 10.6084/m9.figshare.12091155.v2
title: Copy of round 1& 2 (4).xlsx

description: The result of the first and second round of Delphi.
DOI: 10.6084/m9.figshare.12091050
title: Supplementary Material

description: Supplementary material for the paper "Emphasis-based or Opinion-based Policy Change? How Political Parties Respond to the Electorate's Issue Salience of the Environmental Issue"
DOI: 10.25810/5dxz-xm93.28
title: Latin American Newspaper Coverage of Climate Change or Global Warming, 2005-2020 - July 2020

description:         The Media and Climate Change Observatory Data monitors 117 sources (across newspapers, radio and TV) in 53 countries in seven different regions around the world. Data is assembled by accessing archives through the Lexis Nexis, Proquest and Factiva databases via the University of Colorado libraries. More information may be found at: http://mecco.colorado.edu.
DOI: 10.6084/m9.figshare.12091077.v1
title: Genome assembly and gene annotation of Peltaster fructicola

description: The datasets of genome assembly and gene annotation of Peltaster fructicola<br>
DOI: 10.6084/m9.figshare.12091047
title: Homogeneous and narrow bandwidth of spike initiation in rat L1 cortical interneurons

description: Cortical layer 1 contains a population of GABAergic interneurons, considered a key component of information integration, processing, and relaying in neocortical networks. In fact, L1 interneurons combine top-down information with feed-forward sensory inputs in layer 2/3 and 5 pyramidal cells, while filtering their incoming signals. Despite L1 importance for network emerging phenomena, little is known on the dynamics of the spike initiation and encoding properties of its neurons. Using acute brain tissue slices from the rat neocortex, combined with the analysis of an existing database of model neurons, we investigated the dynamical transfer properties of these cells, sampling the entire population of known “electrical classes”, and comparing experiments and model predictions. We found the bandwidth of spike initiation to be significantly narrower than in L2/3 and 5 pyramidal cells, with values below , but without significant heterogeneity in the cell response properties, across distinct electrical types. The upper limit of the neuronal bandwidth was significantly correlated to the mean firing rate, as anticipated from theoretical studies but not reported for pyramidal cells. Finally, at high spectral frequencies, the magnitude of the neuronal response attenuated as a power-law, with an exponent significantly smaller than what reported for pyramidal neurons and reminiscent of the dynamics of a “leaky” integrate-and-fire model of spike initiation. Finally, most of our <i>in vitro</i> results matched quantitatively the numerical simulations of the models, as a further contribution to independently validate the models against novel experimental data.
DOI: 10.6084/m9.figshare.12091155.v1
title: Copy of round 1 (4).xlsx

description: The result of the first round of Delphi.
DOI: 10.6084/m9.figshare.12091047.v1
title: Homogeneous and narrow bandwidth of spike initiation in rat L1 cortical interneurons

description: Cortical layer 1 contains a population of GABAergic interneurons, considered a key component of information integration, processing, and relaying in neocortical networks. In fact, L1 interneurons combine top-down information with feed-forward sensory inputs in layer 2/3 and 5 pyramidal cells, while filtering their incoming signals. Despite L1 importance for network emerging phenomena, little is known on the dynamics of the spike initiation and encoding properties of its neurons. Using acute brain tissue slices from the rat neocortex, combined with the analysis of an existing database of model neurons, we investigated the dynamical transfer properties of these cells, sampling the entire population of known “electrical classes”, and comparing experiments and model predictions. We found the bandwidth of spike initiation to be significantly narrower than in L2/3 and 5 pyramidal cells, with values below , but without significant heterogeneity in the cell response properties, across distinct electrical types. The upper limit of the neuronal bandwidth was significantly correlated to the mean firing rate, as anticipated from theoretical studies but not reported for pyramidal cells. Finally, at high spectral frequencies, the magnitude of the neuronal response attenuated as a power-law, with an exponent significantly smaller than what reported for pyramidal neurons and reminiscent of the dynamics of a “leaky” integrate-and-fire model of spike initiation. Finally, most of our <i>in vitro</i> results matched quantitatively the numerical simulations of the models, as a further contribution to independently validate the models against novel experimental data.
DOI: 10.6084/m9.figshare.12090891
title: The role of the Neotropics as a source of world tetrapod biodiversity

description: BiSSE coding of the species in our study<br>
DOI: 10.6084/m9.figshare.12090891.v1
title: The role of the Neotropics as a source of world tetrapod biodiversity

description: BiSSE coding of the species in our study<br>
DOI: 10.6084/m9.figshare.12090810
title: Combining a bio-based polymer and a natural antifoulant into an eco-friendly antifouling coating

description: Biodegradable polymers are promising binders and carriers for natural antifoulants. In the present study, an antifouling (AF) coating was developed by adding a non-toxic AF compound (butenolide) to a bio-based and biodegradable poly(lactic acid)-based polyurethane. Mass loss measurement showed that the polymer degraded in seawater at a rate of 0.013<b> </b>mg cm<sup>−2</sup><b> </b>day<sup>−1</sup>. Measurements showed that butenolide was released from the coatings into seawater over a period of at least three months. Both the concentration of butenolide in the coatings and the ambient temperature determined the release rate of butenolide. The results further demonstrate that incorporating rosin into the coatings increase the self-renewal rate of the polymer and facilitated the long-term release of butenolide from the coating. The results show that poly(lactic acid)-based polyurethane is a suitable polymer for butenolide-based AF coatings.
DOI: 10.6084/m9.figshare.12090768
title: Appendix.pdf

description: Have a try only
DOI: 10.6084/m9.figshare.12090810.v1
title: Combining a bio-based polymer and a natural antifoulant into an eco-friendly antifouling coating

description: Biodegradable polymers are promising binders and carriers for natural antifoulants. In the present study, an antifouling (AF) coating was developed by adding a non-toxic AF compound (butenolide) to a bio-based and biodegradable poly(lactic acid)-based polyurethane. Mass loss measurement showed that the polymer degraded in seawater at a rate of 0.013<b> </b>mg cm<sup>−2</sup><b> </b>day<sup>−1</sup>. Measurements showed that butenolide was released from the coatings into seawater over a period of at least three months. Both the concentration of butenolide in the coatings and the ambient temperature determined the release rate of butenolide. The results further demonstrate that incorporating rosin into the coatings increase the self-renewal rate of the polymer and facilitated the long-term release of butenolide from the coating. The results show that poly(lactic acid)-based polyurethane is a suitable polymer for butenolide-based AF coatings.
DOI: 10.6084/m9.figshare.12090753
title: Information of abbreviation data set Title: Analgesic Efficacy of Intravenous Nefopam after Spine Surgery: A Randomized, Double-Blind, Placebo-Controlled Trial Untitled Item

description: Information of abbreviation data set<b></b>
DOI: 10.6084/m9.figshare.12090762
title: A novel mutation in <i>TARDBP</i> segregates with amyotrophic lateral sclerosis in a large family with early onset and fast progression

description: <i>Objective:</i> To identify the genetic background of ALS segregating in a large Bedouin family in Israel. <i>Methods:</i> Exome sequencing was carried out on three siblings in a family segregating ALS, two affected and one without neurological symptoms. Filtering for causative variants and for modifiers was carried out. Eight variants were confirmed by Sanger sequencing and genotyped on nine available members of the family (three affected and six unaffected). <i>Results:</i> We report the identification of a novel mutation in <i>TARDBP</i>, p.Ala321Asp, segregating in the family. The patients are affected with early onset (average age 34.5, 21–43 years old) and fast progressive disease. The mutation is in exon 6, in the glycin-rich domain, and is predicted to be deleterious. Additional rare, potentially deleterious variants were observed in the three patients, only one of them, <i>PLEKHG5-</i>Phe538Leu, which is located 4.5 Mb upstream to the <i>TARDBP</i>, was also fully segregating in the family. <i>Conclusion:</i> We identified a novel mutation in <i>TARDBP</i> which segregates with the disease in a large family. Additional rare variants were identified, and the combination of next-generation-sequencing together with linkage analysis was optimal to identify causality and modification, emphasizing the importance of combining the two analyses. Burden of deleterious variants may be associated with early age at onset.
DOI: 10.6084/m9.figshare.12090762.v1
title: A novel mutation in <i>TARDBP</i> segregates with amyotrophic lateral sclerosis in a large family with early onset and fast progression

description: <i>Objective:</i> To identify the genetic background of ALS segregating in a large Bedouin family in Israel. <i>Methods:</i> Exome sequencing was carried out on three siblings in a family segregating ALS, two affected and one without neurological symptoms. Filtering for causative variants and for modifiers was carried out. Eight variants were confirmed by Sanger sequencing and genotyped on nine available members of the family (three affected and six unaffected). <i>Results:</i> We report the identification of a novel mutation in <i>TARDBP</i>, p.Ala321Asp, segregating in the family. The patients are affected with early onset (average age 34.5, 21–43 years old) and fast progressive disease. The mutation is in exon 6, in the glycin-rich domain, and is predicted to be deleterious. Additional rare, potentially deleterious variants were observed in the three patients, only one of them, <i>PLEKHG5-</i>Phe538Leu, which is located 4.5 Mb upstream to the <i>TARDBP</i>, was also fully segregating in the family. <i>Conclusion:</i> We identified a novel mutation in <i>TARDBP</i> which segregates with the disease in a large family. Additional rare variants were identified, and the combination of next-generation-sequencing together with linkage analysis was optimal to identify causality and modification, emphasizing the importance of combining the two analyses. Burden of deleterious variants may be associated with early age at onset.
DOI: 10.6084/m9.figshare.12090753.v1
title: Information of abbreviation data set Title: Analgesic Efficacy of Intravenous Nefopam after Spine Surgery: A Randomized, Double-Blind, Placebo-Controlled Trial Untitled Item

description: Information of abbreviation data set<b></b>
DOI: 10.6084/m9.figshare.12090768.v2
title: Appendix.pdf

description: Have a try only
DOI: 10.6084/m9.figshare.12090768.v1
title: Appendix.pdf

description: Have a try only
DOI: 10.6084/m9.figshare.12090660
title: Dislocation plasticity in FeCoCrMnNi high-entropy alloy: quantitative insights from <i>in situ</i> transmission electron microscopy deformation

description: The mechanical properties of high-entropy alloys (HEAs) are still not deeply understood. Detailed knowledge of the strengthening mechanism, especially, the atomistic origin of solid solution hardening and its interplay with dislocation plasticity is needed. Here, we report on the dislocation glide behavior of a FeCoCrNiMn face-centered cubic (FCC) single crystal studied by <i>in situ</i> deformation in a transmission electron microscope (TEM). The threshold shear stress for dislocation glide in a thin foil is measured from dislocation curvature as exceeding 400 MPa. Interestingly, dislocations are prevented from straightening upon unloading due to high frictional stresses. The fiction stress for dislocation glide in a FeCoCrMnNi HEA is assessed by direct measurement of dislocation line curvature during <i>in situ</i> TEM deformation, which is higher compared to other FCC metals, explaining the outstanding yield and flow stress of the HEA.
DOI: 10.6084/m9.figshare.12090660.v1
title: Dislocation plasticity in FeCoCrMnNi high-entropy alloy: quantitative insights from <i>in situ</i> transmission electron microscopy deformation

description: The mechanical properties of high-entropy alloys (HEAs) are still not deeply understood. Detailed knowledge of the strengthening mechanism, especially, the atomistic origin of solid solution hardening and its interplay with dislocation plasticity is needed. Here, we report on the dislocation glide behavior of a FeCoCrNiMn face-centered cubic (FCC) single crystal studied by <i>in situ</i> deformation in a transmission electron microscope (TEM). The threshold shear stress for dislocation glide in a thin foil is measured from dislocation curvature as exceeding 400 MPa. Interestingly, dislocations are prevented from straightening upon unloading due to high frictional stresses. The fiction stress for dislocation glide in a FeCoCrMnNi HEA is assessed by direct measurement of dislocation line curvature during <i>in situ</i> TEM deformation, which is higher compared to other FCC metals, explaining the outstanding yield and flow stress of the HEA.
DOI: 10.6084/m9.figshare.12090645
title: Silent Myelin-Weighted MR Imaging

description: Region-of-Interest data and MNI space mean/CoV images
DOI: 10.6084/m9.figshare.12090612
title: Simulated datasets for the manuscript "Assessing metacommunity processes through signatures in spatiotemporal turnover of community composition"

description: Distance matrices for the simulated datasets.A commented R script to use these data is provided at https://github.com/franckjabot/metacommunity-analysis-script<br>
DOI: 10.6084/m9.figshare.12090603
title: Data sets for figures 6,7,9,10,11 of the "Systematic method for studying asymmetric single-electron transistor" article

description: Every data set (FIG6, FIG7, FIG9, FIG10, FIG11) contains transport characteristics of some single-electron transistor configuration parameters. The figure (a) in each set is a differential conductance diagram di/dv_T vs v_T, v_G. (b) -- some curves (slices) of differential conductance diagram for the selected v_Gs. (c) -- IV_G-curves for some selected v_Ts. (d) -- IV_T-curves in the single diamond, (e) -- average number of excess electrons on the island vs v_T, v_G, (f) -- standard deviation of the number of excess electrons on the island \sqrt{D(n)} vs v_T, v_G.
DOI: 10.6084/m9.figshare.12090612.v1
title: Simulated datasets for the manuscript "Assessing metacommunity processes through signatures in spatiotemporal turnover of community composition"

description: Distance matrices for the simulated datasets.A commented R script to use these data is provided at https://github.com/franckjabot/metacommunity-analysis-script<br>
DOI: 10.6084/m9.figshare.12090546
title: unigene.blast.cds.fasta

description: Codon usage patterns analysis
DOI: 10.6084/m9.figshare.12090543
title: Table_S1_S2.xlsx

description: Putative novel allergens identified in the transcriptomes of <i>A. pegreffii</i> third stage and fourth stage larvae.
DOI: 10.6084/m9.figshare.12090546.v1
title: unigene.blast.cds.fasta

description: Codon usage patterns analysis
DOI: 10.6084/m9.figshare.12090543.v1
title: Table_S1_S2.xlsx

description: Putative novel allergens identified in the transcriptomes of <i>A. pegreffii</i> third stage and fourth stage larvae.
DOI: 10.6084/m9.figshare.12090480
title: Gene ID - Gene Name translation

description: translation file between Ensembl gene identifiers and the gene name.
DOI: 10.6084/m9.figshare.12090480.v1
title: Gene ID - Gene Name translation

description: translation file between Ensembl gene identifiers and the gene name.