cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.25231577.v1
title: Supplementary Material for: Repetitive DNA mapping in five genera of tree frogs (Amphibia: Anura) from the Atlantic Forest: new highlights on genomic organization in Hylidae

description: Introduction: The tribes Cophomantini, Scinaxini and Dendropsophini are anurans that belong to Hylidae, with wide distribution in tropical and subtropical regions around the world. The taxonomy and systematics of this family remain in a state of ongoing revision. Previous cytogenetic analyses of genera Boana, Bokermannohyla, Ololygon, Scinax and Dendropsophus described some karyotypic characters such as conventional staining, C-banding and NORs, and FISH with specific probes. 
Methods: This study describes for the first time the karyotypes of four species Bokermannohyla ibitipoca, Ololygon luizotavioi, Dendropsophus bipunctatus and Dendropsophus ruschii. Furthermore, we map CA(15) and CAT(10) microsatellite sites and for the aforementioned species and six more species from the same genera, for the insight into the chromosomal evolution within subfamily Hyalinize.
Results: Bok. ibitipoca and O. luizotavioi had 2n= 24 and karyotypic formulae 18m+4sm+2st and 8m+12sm+4st, while D. bipunctatus and D. ruschii showed 2n= 30 and karyotypic formulae 12m+12sm+4st+2t and 10m+10sm+6st+4t, respectively. The diploid numbers and karyotypic formulae revealed here follow the previously reported trend for Hylidae, except Bok. ibitipoca that has a particularity of eight metacentric chromosomes, more than what is commonly found in species of this genus. The microsatellites probes CA(15) and CAT(10) had markings accumulated in blocks in the centromeric, pericentromeric and terminal regions, that were more specific for some species, as well as markings scattered along the chromosomes. We present a comprehensive review table of current data on cytogenetics of these genera.
Conclusion: Our findings showed that the karyotypes of the hylids studied here fit the postulated conserved diploid number and morphological chromosome patterns, while the mapping of these microsatellites enabled us to detect differences between species that share similar chromosomal morphologies.
DOI: 10.6084/m9.figshare.20220289
title: Additional file 8 of The role of ZNF143 overexpression in rat liver cell proliferation

description: Additional file 8: TableS1. A list of DEGs at 72h.
DOI: 10.6084/m9.figshare.20220289.v1
title: Additional file 8 of The role of ZNF143 overexpression in rat liver cell proliferation

description: Additional file 8: TableS1. A list of DEGs at 72h.
DOI: 10.6084/m9.figshare.20220292
title: Additional file 9 of The role of ZNF143 overexpression in rat liver cell proliferation

description: Additional file 9: TableS2. All peaks of ZNF143.
DOI: 10.6084/m9.figshare.20220292.v1
title: Additional file 9 of The role of ZNF143 overexpression in rat liver cell proliferation

description: Additional file 9: TableS2. All peaks of ZNF143.
DOI: 10.6084/m9.figshare.19695995
title: Additional file 1 of Preoperative dynamic quantitative sensory testing in remote pain-free areas is associated with axial pain after posterior cervical spinal surgeries

description: Additional file 1.
DOI: 10.6084/m9.figshare.19695995.v1
title: Additional file 1 of Preoperative dynamic quantitative sensory testing in remote pain-free areas is associated with axial pain after posterior cervical spinal surgeries

description: Additional file 1.
DOI: 10.6084/m9.figshare.19696010.v1
title: Additional file 3 of A large-scale population based organelle pan-genomes construction and phylogeny analysis reveal the genetic diversity and the evolutionary origins of chloroplast and mitochondrion in Brassica napus L.

description: Additional file 3. Supplemetary tables.
DOI: 10.6084/m9.figshare.19696010
title: Additional file 3 of A large-scale population based organelle pan-genomes construction and phylogeny analysis reveal the genetic diversity and the evolutionary origins of chloroplast and mitochondrion in Brassica napus L.

description: Additional file 3. Supplemetary tables.
DOI: 10.6084/m9.figshare.19696052
title: Additional file 1 of Increased expression of prokineticin 2 and its receptor in endometrium of recurrent implantation failure patients decreased the expression of MMP9 important for decidualization

description: Additional file 1. Supplementary material-PCR. Original RT-qPCR data.
DOI: 10.6084/m9.figshare.19696052.v1
title: Additional file 1 of Increased expression of prokineticin 2 and its receptor in endometrium of recurrent implantation failure patients decreased the expression of MMP9 important for decidualization

description: Additional file 1. Supplementary material-PCR. Original RT-qPCR data.
DOI: 10.6084/m9.figshare.7637504
title: Hepatocyte-specific loss of GPS2 in mice reduces non-alcoholic steatohepatitis via activation of PPARα

description: Obesity triggers the genesis of non-alcoholic fatty liver diseases (NAFLD), which involves alterations of regulatory transcription networks and of hepatocyte-selective epigenomes. Here we demonstrate that G protein pathway suppressor 2 (GPS2), a subunit of the nuclear receptor corepressor (NCOR)/ histone deacetylase 3 (HDAC3) complex, is a central component of such networks and accelerates the progression of NAFLD towards non-alcoholic steatohepatitis (NASH). Hepatocyte-specific Gps2 knockout in mice alleviates the development of diet-induced steatosis and fibrosis and causes activation of lipid catabolic genes. Integrative cistrome, epigenome and transcriptome analysis identifies the lipid-sensing peroxisome proliferator-activated receptor alpha (PPARa, NR1C1) as a direct GPS2 target. Liver gene expression data from human patients reveal that GPS2 expression positively correlates with a NASH/fibrosis gene signature. Collectively, our data suggest that the GPS2-PPARa partnership in hepatocytes coordinates the progression of NAFLD in mice and in humans and thus might be therapeutically important.
DOI: 10.6084/m9.figshare.25231583
title: Supplementary Material for: Neoadjuvant Chemotherapy and Pathologic Complete Response in HR+/HER2- Breast Cancer: Impact of Tumor Ki67 and ER Status

description: Introduction: Neoadjuvant chemotherapy (NAC) is extensively employed in breast cancer (BC), primarily for aggressive subtypes like triple-negative and human epidermal growth factor receptor 2 (HER2) positive BC, and in estrogen receptor-positive (ER+)/ HER2- BC with high-risk features. In ER+/HER2- breast cancer, pathological complet rates are much lower (&lt;10%), while axillary dissection rates are higher. This study focuses on hormone receptor positive (HR+)/HER2- BC patients undergoing NAC, examining its impact on pathological complete response (pCR) rates, with specific attention to tumor Ki67 and ER status.
Methods: Retrospective data analysis from Kartal Dr. Lütfi Kırdar City Hospital included HR+/HER2- BC patients who received NAC. Clinicopathological factors, NAC response, and surgical outcomes were assessed. Statistical analyses evaluated the association between Ki67, ER status, and pCR.
Results: Of 203 patients, 11.8% achieved pCR. Ki67 (p&lt;0.001) and ER percentage (p&lt;0.001) significantly correlated with pCR. Higher Ki67 was associated with increased pCR likelihood (HR: 1.03, 95% CI: 1.01-1.05). A Ki67-pCR probability curve revealed a cutoff of 23.5%. ER%-pCR analysis showed decreasing pCR rates with higher ER percentages. Multivariate analysis confirmed Ki67 (p=0.003, HR: 1.02) and ER percentage (p=0.019, HR: 0.97) as independent predictors of pCR probability.
Conclusion: Consideration of Ki67 and ER percentage aids in NAC decisions for HR+/HER2- BC, identifying patients with high NAC response rates, facilitating axillary preservation, and potentially avoiding axillary dissection. The pCR rates in patients with Ki67 ≤ 24 are particularly low, especially in patients with a high ER percentage. In these cases, upfront surgery and adjuvant treatment should be considered instead of NAC.
DOI: 10.6084/m9.figshare.21268973
title: Additional file 1 of Characterization of serum protein expression profiles in the early sarcopenia older adults with low grip strength: a cross-sectional study

description: Additional file 1: Table S1. Results of functional enrichment analysis.
DOI: 10.6084/m9.figshare.21268973.v1
title: Additional file 1 of Characterization of serum protein expression profiles in the early sarcopenia older adults with low grip strength: a cross-sectional study

description: Additional file 1: Table S1. Results of functional enrichment analysis.
DOI: 10.6084/m9.figshare.10258994
title: MOESM1 of Multicentric experience with interferon gamma therapy in sepsis induced immunosuppression. A case series

description: Additional file 1. Supplementary methods
DOI: 10.6084/m9.figshare.10258994.v1
title: MOESM1 of Multicentric experience with interferon gamma therapy in sepsis induced immunosuppression. A case series

description: Additional file 1. Supplementary methods
DOI: 10.6084/m9.figshare.9734762
title: m<sup>6</sup>A mRNA methylation controls autophagy and adipogenesis by targeting <i>Atg5</i> and <i>Atg7</i>

description: <sup>6</sup>-methyladenosine (m<sup>6</sup>A), the most abundant internal modification on mRNAs in eukaryotes, play roles in adipogenesis. However, the underlying mechanism remains largely unclear. Here, we show that m<sup>6</sup>A plays a critical role in regulating macroautophagy/autophagy and adipogenesis through targeting <i>Atg5</i> and <i>Atg7</i>. Mechanistically, knockdown of FTO, a well-known m<sup>6</sup>A demethylase, decreased the expression of ATG5 and ATG7, leading to attenuation of autophagosome formation, thereby inhibiting autophagy and adipogenesis. We proved that FTO directly targeted <i>Atg5</i> and <i>Atg7</i> transcripts and mediated their expression in an m<sup>6</sup>A-dependent manner. Further study identified that <i>Atg5</i> and <i>Atg7</i> were the targets of YTHDF2 (YTH N6-methyladenosine RNA binding protein 2). Upon FTO silencing, <i>Atg5</i> and <i>Atg7</i> transcripts with higher m<sup>6</sup>A levels were captured by YTHDF2, which resulted in mRNA degradation and reduction of protein expression, thus alleviating autophagy and adipogenesis. Furthermore, we generated an adipose-selective <i>fto</i> knockout mouse and find that FTO deficiency decreased white fat mass and impairs ATG5- and ATG7-dependent autophagy <i>in vivo</i>. Together, these findings unveil the functional importance of the m<sup>6</sup>A methylation machinery in autophagy and adipogenesis regulation, which expands our understanding of such interplay that is essential for development of therapeutic strategies in the prevention and treatment of obesity. 3-MA: 3-methyladenine; ACTB: actin, beta; ATG: autophagy-related; Baf A1: bafilomycin A<sub>1</sub>; CEBPA: CCAAT/enhancer binding protein (C/EBP), alpha; CEBPB: CCAAT/enhancer binding protein (C/EBP), beta; FABP4: fatty acid binding protein 4, adipocyte; FTO: fat mass and obesity associated; HFD: high-fat diet; LC-MS/MS: liquid chromatography-tandem mass spectrometry; MAP1LC3B/LC3: microtubule-associated protein 1 light chain 3 beta; m<sup>6</sup>A: N<sup>6</sup>-methyladenosine; MEFs: mouse embryo fibroblasts; MeRIP-qPCR: methylated RNA immunoprecipitation-qPCR; PPARG: peroxisome proliferator activated receptor gamma; RIP: RNA-immunoprecipitation; SAT: subcutaneous adipose tissue; siRNA: small interfering RNA; SQSTM1/p62: sequestosome 1; TEM: transmission electron microscopy; ULK1: unc-51 like kinase 1; VAT: visceral adipose tissue; WAT: white adipose tissue; YTHDF: YTH N6-methyladenosine RNA binding protein
DOI: 10.6084/m9.figshare.9734762.v1
title: m<sup>6</sup>A mRNA methylation controls autophagy and adipogenesis by targeting <i>Atg5</i> and <i>Atg7</i>

description: <sup>6</sup>-methyladenosine (m<sup>6</sup>A), the most abundant internal modification on mRNAs in eukaryotes, play roles in adipogenesis. However, the underlying mechanism remains largely unclear. Here, we show that m<sup>6</sup>A plays a critical role in regulating macroautophagy/autophagy and adipogenesis through targeting <i>Atg5</i> and <i>Atg7</i>. Mechanistically, knockdown of FTO, a well-known m<sup>6</sup>A demethylase, decreased the expression of ATG5 and ATG7, leading to attenuation of autophagosome formation, thereby inhibiting autophagy and adipogenesis. We proved that FTO directly targeted <i>Atg5</i> and <i>Atg7</i> transcripts and mediated their expression in an m<sup>6</sup>A-dependent manner. Further study identified that <i>Atg5</i> and <i>Atg7</i> were the targets of YTHDF2 (YTH N6-methyladenosine RNA binding protein 2). Upon FTO silencing, <i>Atg5</i> and <i>Atg7</i> transcripts with higher m<sup>6</sup>A levels were captured by YTHDF2, which resulted in mRNA degradation and reduction of protein expression, thus alleviating autophagy and adipogenesis. Furthermore, we generated an adipose-selective <i>fto</i> knockout mouse and find that FTO deficiency decreased white fat mass and impairs ATG5- and ATG7-dependent autophagy <i>in vivo</i>. Together, these findings unveil the functional importance of the m<sup>6</sup>A methylation machinery in autophagy and adipogenesis regulation, which expands our understanding of such interplay that is essential for development of therapeutic strategies in the prevention and treatment of obesity. 3-MA: 3-methyladenine; ACTB: actin, beta; ATG: autophagy-related; Baf A1: bafilomycin A<sub>1</sub>; CEBPA: CCAAT/enhancer binding protein (C/EBP), alpha; CEBPB: CCAAT/enhancer binding protein (C/EBP), beta; FABP4: fatty acid binding protein 4, adipocyte; FTO: fat mass and obesity associated; HFD: high-fat diet; LC-MS/MS: liquid chromatography-tandem mass spectrometry; MAP1LC3B/LC3: microtubule-associated protein 1 light chain 3 beta; m<sup>6</sup>A: N<sup>6</sup>-methyladenosine; MEFs: mouse embryo fibroblasts; MeRIP-qPCR: methylated RNA immunoprecipitation-qPCR; PPARG: peroxisome proliferator activated receptor gamma; RIP: RNA-immunoprecipitation; SAT: subcutaneous adipose tissue; siRNA: small interfering RNA; SQSTM1/p62: sequestosome 1; TEM: transmission electron microscopy; ULK1: unc-51 like kinase 1; VAT: visceral adipose tissue; WAT: white adipose tissue; YTHDF: YTH N6-methyladenosine RNA binding protein
DOI: 10.6084/m9.figshare.9734768
title: Genetic compensation by <i>epob</i> in pronephros development in <i>epoa</i> mutant zebrafish

description: Zebrafish erythropoietin a (epoa) is a well characterized regulator of red blood cell formation. Recent morpholino mediated knockdown data have also identified <i>epoa</i> being essential for physiological pronephros development in zebrafish, which is driven by blocking apoptosis in developing kidneys. Yet, zebrafish mutants for <i>epoa</i> have not been described so far. In order to compare a transient knockdown vs. permanent knockout for <i>epoa</i> in zebrafish on pronephros development, we used CRISPR/Cas9 technology to generate <i>epoa</i> knockout zebrafish mutants and we performed structural and functional studies on pronephros development. In contrast to <i>epoa</i> morphants, <i>epoa<sup>−/-</sup></i> zebrafish mutants showed normal pronephros structure; however, a previously uncharacterized gene in zebrafish, named <i>epob</i>, was identified and upregulated in <i>epoa<sup>−/-</sup></i> mutants. <i>epob</i> knockdown altered pronephros development, which was further aggravated in <i>epoa<sup>−/-</sup></i> mutants. Likewise, <i>epoa</i> and <i>epob</i> morphants regulated similar and differential gene signatures related to kidney development in zebrafish. In conclusion, stable loss of <i>epoa</i> during embryonic development can be compensated by <i>epob</i> leading to phenotypical discrepancies in <i>epoa</i> knockdown and knockout zebrafish embryos.
DOI: 10.6084/m9.figshare.9734768.v1
title: Genetic compensation by <i>epob</i> in pronephros development in <i>epoa</i> mutant zebrafish

description: Zebrafish erythropoietin a (epoa) is a well characterized regulator of red blood cell formation. Recent morpholino mediated knockdown data have also identified <i>epoa</i> being essential for physiological pronephros development in zebrafish, which is driven by blocking apoptosis in developing kidneys. Yet, zebrafish mutants for <i>epoa</i> have not been described so far. In order to compare a transient knockdown vs. permanent knockout for <i>epoa</i> in zebrafish on pronephros development, we used CRISPR/Cas9 technology to generate <i>epoa</i> knockout zebrafish mutants and we performed structural and functional studies on pronephros development. In contrast to <i>epoa</i> morphants, <i>epoa<sup>−/-</sup></i> zebrafish mutants showed normal pronephros structure; however, a previously uncharacterized gene in zebrafish, named <i>epob</i>, was identified and upregulated in <i>epoa<sup>−/-</sup></i> mutants. <i>epob</i> knockdown altered pronephros development, which was further aggravated in <i>epoa<sup>−/-</sup></i> mutants. Likewise, <i>epoa</i> and <i>epob</i> morphants regulated similar and differential gene signatures related to kidney development in zebrafish. In conclusion, stable loss of <i>epoa</i> during embryonic development can be compensated by <i>epob</i> leading to phenotypical discrepancies in <i>epoa</i> knockdown and knockout zebrafish embryos.
DOI: 10.6084/m9.figshare.14977650
title: Material intensity

description: 13 material intensity during 1978-2018 in China
DOI: 10.34740/kaggle/dsv/7635131
title: DoE_Reachability
DOI: 10.6084/m9.figshare.21269176.v1
title: Additional file 13 of Transcriptome analysis reveals the roles of phytohormone signaling in tea plant (Camellia sinensis L.) flower development

description: Additional file 13: Table S10: Two-way ANOVA test F-value of genes expression levels related to salicylic acid biosynthesis and signaling transduction for three C. sinensis cultivars (BY1, HJY and SCZ) affected by development stage (S) and cultivar (C).
DOI: 10.6084/m9.figshare.21269176
title: Additional file 13 of Transcriptome analysis reveals the roles of phytohormone signaling in tea plant (Camellia sinensis L.) flower development

description: Additional file 13: Table S10: Two-way ANOVA test F-value of genes expression levels related to salicylic acid biosynthesis and signaling transduction for three C. sinensis cultivars (BY1, HJY and SCZ) affected by development stage (S) and cultivar (C).
DOI: 10.6084/m9.figshare.21269179
title: Additional file 14 of Transcriptome analysis reveals the roles of phytohormone signaling in tea plant (Camellia sinensis L.) flower development

description: Additional file 14: Table S11: Two-way ANOVA test F-value of genes expression levels related to jasmonic biosynthesis and signaling transduction for three C. sinensis cultivars (BY1, HJY and SCZ) affected by development stage (S) and cultivar (C).
DOI: 10.6084/m9.figshare.21269167
title: Additional file 10 of Transcriptome analysis reveals the roles of phytohormone signaling in tea plant (Camellia sinensis L.) flower development

description: Additional file 10: Table S7: Two-way ANOVA test F-value of genes expression levels related to cytokinin biosynthesis and signaling transduction for three C. sinensis cultivars (BY1, HJY and SCZ) affected by development stage (S) and cultivar (C).
DOI: 10.6084/m9.figshare.21269179.v1
title: Additional file 14 of Transcriptome analysis reveals the roles of phytohormone signaling in tea plant (Camellia sinensis L.) flower development

description: Additional file 14: Table S11: Two-way ANOVA test F-value of genes expression levels related to jasmonic biosynthesis and signaling transduction for three C. sinensis cultivars (BY1, HJY and SCZ) affected by development stage (S) and cultivar (C).
DOI: 10.6084/m9.figshare.21269167.v1
title: Additional file 10 of Transcriptome analysis reveals the roles of phytohormone signaling in tea plant (Camellia sinensis L.) flower development

description: Additional file 10: Table S7: Two-way ANOVA test F-value of genes expression levels related to cytokinin biosynthesis and signaling transduction for three C. sinensis cultivars (BY1, HJY and SCZ) affected by development stage (S) and cultivar (C).
DOI: 10.6084/m9.figshare.21269170
title: Additional file 11 of Transcriptome analysis reveals the roles of phytohormone signaling in tea plant (Camellia sinensis L.) flower development

description: Additional file 11: Table S8: Two-way ANOVA test F-value of genes expression levels related to abscisic acid biosynthesis and signaling transduction for three C. sinensis cultivars (BY1, HJY and SCZ) affected by development stage (S) and cultivar (C).
DOI: 10.6084/m9.figshare.21269170.v1
title: Additional file 11 of Transcriptome analysis reveals the roles of phytohormone signaling in tea plant (Camellia sinensis L.) flower development

description: Additional file 11: Table S8: Two-way ANOVA test F-value of genes expression levels related to abscisic acid biosynthesis and signaling transduction for three C. sinensis cultivars (BY1, HJY and SCZ) affected by development stage (S) and cultivar (C).
DOI: 10.6084/m9.figshare.21269173
title: Additional file 12 of Transcriptome analysis reveals the roles of phytohormone signaling in tea plant (Camellia sinensis L.) flower development

description: Additional file 12: Table S9: Two-way ANOVA test F-value of genes expression levels related to gibberellin biosynthesis and signaling transduction for three C. sinensis cultivars (BY1, HJY and SCZ) affected by development stage (S) and cultivar (C).
DOI: 10.25549/pcra-c14-56396
title: Redemption tidings, vol. 37, nos. 1-52, 1 Jan. - 22 Dec. 1961

description: [description english/roman)] Issued weekly. "A full gospel magazine" -- subtitle.
DOI: 10.15468/dl.k42q9i
title: Occurrence Download

description: A dataset containing 3921 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Hovea linearis (Sm.) R.Br.",
 {
 "or" : [
 "BasisOfRecord is Human Observation",
 "BasisOfRecord is Observation"
 ]
 },
 "HasCoordinate is true",
 "HasGeospatialIssue is false"
 ]
}

 The dataset includes 3921 records from 15 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0045618-191105090559680/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.wntafx
title: Occurrence Download

description: A dataset containing 627 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Polypogon australis Brongn."
 ]
}

 The dataset includes 627 records from 81 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0092644-230530130749713/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.