cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.21968315.v6
title: Supplementary Material for: Progression of Recurrent Pancreatitis to Chronic Pancreatitis within 3 Years due to <i>SPINK1</i> Mutation IVS3+2T&gt;C

description: When the etiology of pancreatitis cannot be determined despite sufficient investigation, recurrence and progression to chronic pancreatitis often involve genetic mutations. Herein, we describe a case of recurrent pancreatitis with the IVS3+2T&gt;C mutation in the serine protease inhibitor Kazal type 1 (<i>SPINK1</i>) gene that progressed to chronic pancreatitis in only 3 years. A 35-year-old man was referred to our hospital, where he was diagnosed with mild pancreatitis and was treated conservatively. However, the patient experienced recurrent episodes of pancreatitis, which progressed to become chronic pancreatitis with a pancreatic calcification 1 year later. After 3 years, the patient developed pancreatic duct stenosis and required a pancreatic duct stent placement. Regarding the cause of chronic pancreatitis, alcohol abuse was ruled out based on history taking. Considering the course of treatment, autoimmune pancreatitis and obstructive pancreatitis, such as pancreatic divisum, were also ruled out. Finally, a germline genetic test was performed to determine the etiology of pancreatitis, which revealed the IVS3+2T&gt;C mutation in <i>SPINK1</i>. This case shows the importance of genetic testing in patients with idiopathic pancreatitis to determine their etiology and is a rare incident that can report the progression of the disease from acute to chronic pancreatitis.
DOI: 10.6084/m9.figshare.21981170.v1
title: Supplementary Material for: Possible Efficacy of Vedolizumab, an Anti-α4β7 Integrin Antibody, in Palmoplantar Pustulosis

description: Palmoplantar pustulosis (PPP) is a chronic skin inflammatory disease in which blisters and pustules repeatedly develop on palms and soles. PPP is often refractory to topical therapy, oral therapy, phototherapy, and biologics that are usually applied for PPP. We report a patient with PPP improved by vedolizumab (anti-α4β7 integrin antibody) treatment for ulcerative colitis, suggesting the possibility of a new molecular target for PPP therapy.
DOI: 10.6084/m9.figshare.21981181
title: Treatment of chronic generalized periodontitis in patients with underlying hypovitaminosis D: randomized comparative clinical trial

description: Abstract Objectives This study aims to evaluate the dynamics of clinical and laboratory indicators of the periodontal state and hemodynamics in patients receiving pharmaceutical intervention for the treatment of vitamin D deficiency as a part of the complex therapy of chronic generalized periodontitis. Methodology This was a randomized prospective comparative clinical trial. It involved 110 patients with moderate generalized periodontitis and vitamin D deficiency (25(OH)&lt;50 nmol/L) who were divided into two experimental groups. One experimental group received conventional treatment, whereas the other group received conventional treatment with pharmaceutical intervention for the treatment of vitamin D deficiency(vitamin D3 + calcium). Results A significant reduction in periodontal inflammation was observed across all study groups starting from day 14 of treatment. However, in a longer perspective (12 and 18 months after treatment), the indices analyzed remained fairly stable and corresponded to the chronic periodontitis clinical stabilization stage in both groups. The conventional treatment group demonstrated a marked tendency for all indicators to return to the baseline. Conclusions Pharmacotherapy of vitamin D deficiency contributed to the normalization of periodontal microcirculation (the σ and Kv values approached those of healthy periodontium) as evidenced by the immediate and long-term follow-up results. Clinical observation of patients suffering from moderate chronic generalized periodontitis with underlying hypovitaminosis D makes an argument to the use of vitamin D supplementation for the correction of vitamin D deficiency as a part of the complex treatment. Trial registration number: NCT67823273
DOI: 10.6084/m9.figshare.21981181.v1
title: Treatment of chronic generalized periodontitis in patients with underlying hypovitaminosis D: randomized comparative clinical trial

description: Abstract Objectives This study aims to evaluate the dynamics of clinical and laboratory indicators of the periodontal state and hemodynamics in patients receiving pharmaceutical intervention for the treatment of vitamin D deficiency as a part of the complex therapy of chronic generalized periodontitis. Methodology This was a randomized prospective comparative clinical trial. It involved 110 patients with moderate generalized periodontitis and vitamin D deficiency (25(OH)&lt;50 nmol/L) who were divided into two experimental groups. One experimental group received conventional treatment, whereas the other group received conventional treatment with pharmaceutical intervention for the treatment of vitamin D deficiency(vitamin D3 + calcium). Results A significant reduction in periodontal inflammation was observed across all study groups starting from day 14 of treatment. However, in a longer perspective (12 and 18 months after treatment), the indices analyzed remained fairly stable and corresponded to the chronic periodontitis clinical stabilization stage in both groups. The conventional treatment group demonstrated a marked tendency for all indicators to return to the baseline. Conclusions Pharmacotherapy of vitamin D deficiency contributed to the normalization of periodontal microcirculation (the σ and Kv values approached those of healthy periodontium) as evidenced by the immediate and long-term follow-up results. Clinical observation of patients suffering from moderate chronic generalized periodontitis with underlying hypovitaminosis D makes an argument to the use of vitamin D supplementation for the correction of vitamin D deficiency as a part of the complex treatment. Trial registration number: NCT67823273
DOI: 10.6084/m9.figshare.21981182
title: The Regulation of the New Bidding Law: Definition of the Institutional Logic Prevalent in a Field

description: ABSTRACT Objective: the present research analyzes how regulatory definitions occur in a field, in which participants defend multiple logics in the public procurement of large-scale engineering works and services, with a focus on the requisition of guarantee insurance. It also discusses a take-back clause and the percentage of the contract value to be insured. Theoretical approach: this work is part of the discussion about how an institutional logic is constituted, given the competition between multiple logics in a field. Method: the research is focused on discussions relevant to the field. Data collection was carried out through a documentary survey of the analysis of speeches in Congress, as well as interviews with relevant actors in the field using a semi-structured script. Results: the conflicts between logics are resolved through combinations with elements from other field logics. They emphasize the power of actors’ coalitions to define regulatory issues. The study, thus, pointed out how the participants managed to reduce the influence of the logic defended by the insurance market, in favor of the interest of construction companies in the drafting of the project, showing that different market logics can contradict one another. Finally, elements exogenous to the logic under construction are fundamental in its formulation. Conclusions: the theoretical contribution of the study indicates that the institutional logic that becomes prevalent in a complex field is the result of the imposition of a coalition of actors combining elements from distinct logics. However, the coalitions may be different for each of the questions examined.
DOI: 10.6084/m9.figshare.21981182.v1
title: The Regulation of the New Bidding Law: Definition of the Institutional Logic Prevalent in a Field

description: ABSTRACT Objective: the present research analyzes how regulatory definitions occur in a field, in which participants defend multiple logics in the public procurement of large-scale engineering works and services, with a focus on the requisition of guarantee insurance. It also discusses a take-back clause and the percentage of the contract value to be insured. Theoretical approach: this work is part of the discussion about how an institutional logic is constituted, given the competition between multiple logics in a field. Method: the research is focused on discussions relevant to the field. Data collection was carried out through a documentary survey of the analysis of speeches in Congress, as well as interviews with relevant actors in the field using a semi-structured script. Results: the conflicts between logics are resolved through combinations with elements from other field logics. They emphasize the power of actors’ coalitions to define regulatory issues. The study, thus, pointed out how the participants managed to reduce the influence of the logic defended by the insurance market, in favor of the interest of construction companies in the drafting of the project, showing that different market logics can contradict one another. Finally, elements exogenous to the logic under construction are fundamental in its formulation. Conclusions: the theoretical contribution of the study indicates that the institutional logic that becomes prevalent in a complex field is the result of the imposition of a coalition of actors combining elements from distinct logics. However, the coalitions may be different for each of the questions examined.
DOI: 10.6084/m9.figshare.20039961
title: Mobility in urban center by walking circuits using the PROMETHEE multicriteria method, Campinas case study

description: Abstract This work takes walking as a form of mobility in an urban center and develops a methodology for determining more accessible routes for pedestrians who arrive at urban bus terminals and wish to reach points of interest. The proposal objective is to offer better routes, for a social class coming from peripheral neighborhoods, with access to essential services. The proposal was applied to the central region of Campinas-SP, characterized by commercial and service activities, served by two important urban public terminals. In determining the best walking route, three macros indicator were used: Environment indicator, representing physical characteristics of the walking environment; Comfort indicator, represented by visual attractiveness and local comfort; and Safety indicator representing public and personal security. Using the PROMETHEE multicriteria method, the best routes connecting points of Origin (Urban Terminal) to points of Destination in the urban center of Campinas were defined. The implementation of these routes by local government will provide the urban center with walking space that meets the interests of the citizen in three aspects: the environment, comfort, and safety.
DOI: 10.6084/m9.figshare.20039961.v1
title: Mobility in urban center by walking circuits using the PROMETHEE multicriteria method, Campinas case study

description: Abstract This work takes walking as a form of mobility in an urban center and develops a methodology for determining more accessible routes for pedestrians who arrive at urban bus terminals and wish to reach points of interest. The proposal objective is to offer better routes, for a social class coming from peripheral neighborhoods, with access to essential services. The proposal was applied to the central region of Campinas-SP, characterized by commercial and service activities, served by two important urban public terminals. In determining the best walking route, three macros indicator were used: Environment indicator, representing physical characteristics of the walking environment; Comfort indicator, represented by visual attractiveness and local comfort; and Safety indicator representing public and personal security. Using the PROMETHEE multicriteria method, the best routes connecting points of Origin (Urban Terminal) to points of Destination in the urban center of Campinas were defined. The implementation of these routes by local government will provide the urban center with walking space that meets the interests of the citizen in three aspects: the environment, comfort, and safety.
DOI: 10.6084/m9.figshare.21981184
title: Like, Share, and React: Twitter Capture for Research and Corporate Decisions

description: ABSTRACT Context: social media have an immense amount of information, being a space for its dissemination. Individuals, online connections, are able to filter or give visibility to certain information, to the detriment of others. The central problem lies in monitoring posts and reactions aimed at corporate actions and strategies. In addition to this monitoring, companies can make decisions based on the data collected. Objective: to develop and structure a social media management tool. Methods: to achieve the general objective, the article was developed in three main steps. The first was to suggest a free software script for capturing and initial analysis of Twitter posts. The second step was to categorize this analysis and identify resources and competencies needed by companies. Finally, actions to be taken by companies for social media management were suggested. Results: the developed script enabled the automated extraction of data, which were stored in a database for analysis and management of online interactions. The actions were proposed based on the case study developed. Conclusions: in the practical field, this study contributes to the process of extracting data from Twitter by proposing a new script for capturing data, identifying the main categories of influence of digital activists and monitoring social media through strategic actions. By demonstrating that the script is effective in extracting data, it is possible to carry out further studies and implement the social media management monitoring process.
DOI: 10.6084/m9.figshare.21981184.v1
title: Like, Share, and React: Twitter Capture for Research and Corporate Decisions

description: ABSTRACT Context: social media have an immense amount of information, being a space for its dissemination. Individuals, online connections, are able to filter or give visibility to certain information, to the detriment of others. The central problem lies in monitoring posts and reactions aimed at corporate actions and strategies. In addition to this monitoring, companies can make decisions based on the data collected. Objective: to develop and structure a social media management tool. Methods: to achieve the general objective, the article was developed in three main steps. The first was to suggest a free software script for capturing and initial analysis of Twitter posts. The second step was to categorize this analysis and identify resources and competencies needed by companies. Finally, actions to be taken by companies for social media management were suggested. Results: the developed script enabled the automated extraction of data, which were stored in a database for analysis and management of online interactions. The actions were proposed based on the case study developed. Conclusions: in the practical field, this study contributes to the process of extracting data from Twitter by proposing a new script for capturing data, identifying the main categories of influence of digital activists and monitoring social media through strategic actions. By demonstrating that the script is effective in extracting data, it is possible to carry out further studies and implement the social media management monitoring process.
DOI: 10.6084/m9.figshare.21841191
title: data and code

description: Data from China Meteorological Data Service Center、 National Center for Environmental Prediction/National Center and National Climate Center.
DOI: 10.6084/m9.figshare.21841191.v1
title: data and code

description: Data from China Meteorological Data Service Center、 National Center for Environmental Prediction/National Center and National Climate Center.
DOI: 10.6084/m9.figshare.21706754
title: Utilization of Biotechnology, Neurotransmitter and Cytogenetic Indices in Selecting Pigeon Breeds

description: ABSTRACT Investigations into LDH-A and DR-D4 genes polymorphism, neurotransmitter values and cytogenetic indices of 3 sexed pigeon breeds; non-racing pigeons, (wild rock), racing long distances pigeons (Jan Aarden) and racing short distances pigeons (Janssen) have been performed. The long-distances pigeon showed the highest brain neurotransmitters concentration (p&lt;0.001) among pigeon breeds. Both LDH-A and DR-D4 genes polymorphism indicate the presence of different biodiversity values among pigeon breeds. The variations appeared on the position length 389bp for LDH-A polymorphism, and on two positions length of 418bp and 524bp for DR-D4 polymorphism of long distances male pigeon indicate the presence of unique diversity and overall differences in the amino acids structure in this breed. The protein sequence of both genes showed that in the position of 60 for LDH-A gene the amino acid K (lys) was converted to E (glu), while, in the positions of 117 and 153 for DR-D4 gene the amino acid R (arg) and L (leu) were converted to S (ser) and F (phe) only in long distances male pigeon compared to the other breeds. Moreover, there were slight differences in cytogenetic indices detected among the three pigeon breeds. It can be concluded that both DR-D4 and LDH-A genes polymorphism and neurotransmitters estimations in the brain tissue of racing pigeon would be useful indices for the differentiation and genetic characterization of pigeon breeds and provide a foundation for developing sustainable genetic improvement and conservation programs of the breeding and selecting racing pigeon breeders.
DOI: 10.6084/m9.figshare.21706754.v1
title: Utilization of Biotechnology, Neurotransmitter and Cytogenetic Indices in Selecting Pigeon Breeds

description: ABSTRACT Investigations into LDH-A and DR-D4 genes polymorphism, neurotransmitter values and cytogenetic indices of 3 sexed pigeon breeds; non-racing pigeons, (wild rock), racing long distances pigeons (Jan Aarden) and racing short distances pigeons (Janssen) have been performed. The long-distances pigeon showed the highest brain neurotransmitters concentration (p&lt;0.001) among pigeon breeds. Both LDH-A and DR-D4 genes polymorphism indicate the presence of different biodiversity values among pigeon breeds. The variations appeared on the position length 389bp for LDH-A polymorphism, and on two positions length of 418bp and 524bp for DR-D4 polymorphism of long distances male pigeon indicate the presence of unique diversity and overall differences in the amino acids structure in this breed. The protein sequence of both genes showed that in the position of 60 for LDH-A gene the amino acid K (lys) was converted to E (glu), while, in the positions of 117 and 153 for DR-D4 gene the amino acid R (arg) and L (leu) were converted to S (ser) and F (phe) only in long distances male pigeon compared to the other breeds. Moreover, there were slight differences in cytogenetic indices detected among the three pigeon breeds. It can be concluded that both DR-D4 and LDH-A genes polymorphism and neurotransmitters estimations in the brain tissue of racing pigeon would be useful indices for the differentiation and genetic characterization of pigeon breeds and provide a foundation for developing sustainable genetic improvement and conservation programs of the breeding and selecting racing pigeon breeders.
DOI: 10.6084/m9.figshare.21981187
title: Molecular identification of Austrodiplostomum sp., an eye parasite among farmed tambaqui in Amazonia

description: Abstract Austrodiplostomum Szidat & Nani, 1951 is a genus of parasitic digenetic trematodes widely distributed in the Neotropical region. Infects a wide variety of species, families and requests for freshwater fish. We identify samples of Austrodiplostomum sp, based on metacercariae isolates from eyes of tambaqui (Colossoma macropomum), a fish of high commercial importance in Brazil, and widely consumed by the population of the northern region. The sequences obtained clustered with A. compactum. This is the first report of the occurrence of diplostomids in farmed tambaqui in Amazonia.
DOI: 10.6084/m9.figshare.21981187.v1
title: Molecular identification of Austrodiplostomum sp., an eye parasite among farmed tambaqui in Amazonia

description: Abstract Austrodiplostomum Szidat & Nani, 1951 is a genus of parasitic digenetic trematodes widely distributed in the Neotropical region. Infects a wide variety of species, families and requests for freshwater fish. We identify samples of Austrodiplostomum sp, based on metacercariae isolates from eyes of tambaqui (Colossoma macropomum), a fish of high commercial importance in Brazil, and widely consumed by the population of the northern region. The sequences obtained clustered with A. compactum. This is the first report of the occurrence of diplostomids in farmed tambaqui in Amazonia.
DOI: 10.6084/m9.figshare.20039988
title: Public development plan based on coproduction and slow principles: an analytical scheme by action research

description: Abstract This study aims to investigate and reflect on the evidence of a development plan based on the coproduction the population and the government of a small municipality, based on the principles of the Slow City Movement (SCM). A descriptive exploratory research was conducted with a qualitative approach. The main guiding strategy of the research, consisted of the action research method carried out in the municipality of Rio Doce, in Minas Gerais, Brazil. The results show that the space for dialogue between the population and the government was relevant and allowed the coproduction of a municipal planning with micro and macro elements and within the slow city principles. Also, traditional practices linked to culture with the use of local environmental resources were included, involving popular knowledge, technologies of social origin and the knowledge of the daily life of the community in a project of future desired by the population.
DOI: 10.6084/m9.figshare.20039997
title: Privatization and financialization of infrastructures in Brazil: agents and rentier strategies after global financial crisis of 2008

description: Abstract Infrastructure production in Brazil has undergone important transformations since the 1990s, articulating itself with the country’s alignment with a neoliberal agenda. The adoption of countercyclical policies in response to the 2008 crisis, expands and makes the nature of these processes even more complex. The historical role of the BNDES in conducting the privatization processes and the growing economic and political power of the major national contractors are taking is central elements to understand this process. Discussing with the international debate about privatization and financialization of infrastructures, we seek to understand the Brazilian case in order to problematize the increase centrality of rent accumulation. The article is developed through the analysis of institutional arrangements, dominant agents and accumulation strategies, considering the systematization and critical interpretation of the bibliography, documents and data referring to the transformation of the sector.