cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.6377657
title: Harnessing the value of open innovation: change in the moderating role of absorptive capability

description: We answered to the research questions as follows. Has there been any change in the moderating effects of research and development (R&D) between open innovation (OI) and firms’ performance of small and medium enterprises (SMEs) in the South Korean manufacturing sector since the global financial crisis in 2007. And, if so, how about the changes? First, with the increase in OI of SMEs in the South Korean manufacturing sector, their performance moved in an inverted U-shaped curve in 2005, and 2014 altogether. Second, the R&D investment by SMEs in the South Korean manufacturing sector had a net effect on their performance in 2005, and 2014 altogether. Third, the R&D investment by SMEs in the South Korean manufacturing had accelerated the effect of OI on their performance in 2005. But, the R&D investment by SMEs in the South Korean manufacturing sector failed to moderate the effect of OI on their performance in 2014.
DOI: 10.6084/m9.figshare.6377657.v1
title: Harnessing the value of open innovation: change in the moderating role of absorptive capability

description: We answered to the research questions as follows. Has there been any change in the moderating effects of research and development (R&D) between open innovation (OI) and firms’ performance of small and medium enterprises (SMEs) in the South Korean manufacturing sector since the global financial crisis in 2007. And, if so, how about the changes? First, with the increase in OI of SMEs in the South Korean manufacturing sector, their performance moved in an inverted U-shaped curve in 2005, and 2014 altogether. Second, the R&D investment by SMEs in the South Korean manufacturing sector had a net effect on their performance in 2005, and 2014 altogether. Third, the R&D investment by SMEs in the South Korean manufacturing had accelerated the effect of OI on their performance in 2005. But, the R&D investment by SMEs in the South Korean manufacturing sector failed to moderate the effect of OI on their performance in 2014.
DOI: 10.6084/m9.figshare.6377600
title: Sputtering Yield Be F-Tridyn

description: Sputtering yield for Be calculated using F-Tridyn for energies up to 1000 eV
DOI: 10.6084/m9.figshare.6377600.v1
title: SputtringYieldBe.mat

description: Sputtering yield for Be calculated using F-Tridyn for energies up to 1000 eV
DOI: 10.6084/m9.figshare.6377600.v3
title: Sputtering Yield Be F-Tridyn

description: Sputtering yield for Be calculated using F-Tridyn for energies up to 1000 eV
DOI: 10.6084/m9.figshare.6377600.v2
title: SputtringYieldBe.mat

description: Sputtering yield for Be calculated using F-Tridyn for energies up to 1000 eV
DOI: 10.6084/m9.figshare.6377408
title: AIHs_goias_2015_geolocalizadas

description: Todas as internações autorizadas pelo SIH, referentes a Goias, para o ano de 2015, geolocalizadas. É um arquivo complementar ao script de checagem.
DOI: 10.6084/m9.figshare.6377408.v1
title: AIHs_goias_2015_geolocalizadas

description: Todas as internações autorizadas pelo SIH, referentes a Goias, para o ano de 2015, geolocalizadas. É um arquivo complementar ao script de checagem.
DOI: 10.6084/m9.figshare.6376592
title: Markovian Precision

description: This dataset contains all the models and tools necessary to reproduce the experiments reported in the paper titled:<br>"Abstract-and-Compare: A Family of Scalable PrecisionMeasures for Automated Process Discovery"
DOI: 10.6084/m9.figshare.6376592.v1
title: markovian precision

description: This dataset contains all the models and tools necessary to reproduce the experiments reported in the paper titled:<br>"Abstract-and-Compare: A Family of Scalable PrecisionMeasures for Automated Process Discovery"
DOI: 10.6084/m9.figshare.6376481
title: Comparative identification and evolutionary relationship of fatty acid desaturase (<i>FAD</i>) genes in some oil crops: the sunflower model for evaluation of gene expression pattern under drought stress

description: Sunflower (<i>Helianthus annuus L.</i>) and some oil crops have considerable economic value, making them important for commercial use. The fatty acid content of their seeds is crucial for proper nutrition. Additionally, the desaturation reaction via fatty acid desaturases (FADs) leads to formation of double bonds in fatty acids and is an essential step in fatty acid biosynthesis. This study aimed to identify and compare some fatty acid desaturase gene members in sunflower and other oil crops. Totally, 33 <i>FAD</i> genes from sunflower, 19 from sesame, 20 from canola, 25 from cacao and 46 from flax were analysed. The FAD members had roles in oxidation–reduction processes, fatty acid biosynthetic processes or lipid metabolic processes. Comparative phylogenetic and motif analysis revealed a conserved structure among FAD members belonging to various oil crops. The average <i>Ka/Ks</i> rates calculated on the basis of orthologous gene analysis were 0.04, 0.05 and 0.05 between sunflower and, respectively, canola, cacao and sesame. The most recent divergence time between sunflower and cacao was estimated at an average of 100 million years ago (MYA). This was followed by flax, sesame and canola with an average of 101 MYA, 114 MYA and 149 MYA, respectively. Alpha-helices were dominant in the predicted 3D structures of FAD proteins. The <i>FAB2</i> expression levels from a drought tolerant sunflower variety were not affected by drought. The characterisation of desaturase family members in economically valuable oil crops could be useful for functional cloning studies to enhance the unsaturated fatty acid contents of the plants.
DOI: 10.6084/m9.figshare.6376481.v1
title: Comparative identification and evolutionary relationship of fatty acid desaturase (<i>FAD</i>) genes in some oil crops: the sunflower model for evaluation of gene expression pattern under drought stress

description: Sunflower (<i>Helianthus annuus L.</i>) and some oil crops have considerable economic value, making them important for commercial use. The fatty acid content of their seeds is crucial for proper nutrition. Additionally, the desaturation reaction via fatty acid desaturases (FADs) leads to formation of double bonds in fatty acids and is an essential step in fatty acid biosynthesis. This study aimed to identify and compare some fatty acid desaturase gene members in sunflower and other oil crops. Totally, 33 <i>FAD</i> genes from sunflower, 19 from sesame, 20 from canola, 25 from cacao and 46 from flax were analysed. The FAD members had roles in oxidation–reduction processes, fatty acid biosynthetic processes or lipid metabolic processes. Comparative phylogenetic and motif analysis revealed a conserved structure among FAD members belonging to various oil crops. The average <i>Ka/Ks</i> rates calculated on the basis of orthologous gene analysis were 0.04, 0.05 and 0.05 between sunflower and, respectively, canola, cacao and sesame. The most recent divergence time between sunflower and cacao was estimated at an average of 100 million years ago (MYA). This was followed by flax, sesame and canola with an average of 101 MYA, 114 MYA and 149 MYA, respectively. Alpha-helices were dominant in the predicted 3D structures of FAD proteins. The <i>FAB2</i> expression levels from a drought tolerant sunflower variety were not affected by drought. The characterisation of desaturase family members in economically valuable oil crops could be useful for functional cloning studies to enhance the unsaturated fatty acid contents of the plants.
DOI: 10.6084/m9.figshare.6374720
title: The effect of feeding and mate presence on the pheromone production of the spruce beetle, Dendroctonus rufipennis (Coleoptera: Curculionidae) - Dataset

description: Amounts (ug/beetle) of known pheromone components produced by male and female spruce beetles (<i>Dendroctonus rufipennis</i>), either alone or paired with the opposite sex, and fed for 0, 24, or 48 hours in recently cut white spruce feeding bolts. The beetles were collected as emerging adults from infested spruce harvested in Nova Scotia.<br>Pheromone extractions were performed by hindgut dissections into 4:1 pentane:hexane spiked with 5 ng/ul of heptyl acetate (internal standard), and were later quantified by GC-MS.<br>
DOI: 10.6084/m9.figshare.6374222
title: Computational simulations assessment of mutations impact on streptokinase (SK) from a group G <i>streptococci</i> with enhanced activity – insights into the functional roles of structural dynamics flexibility of SK and stabilization of SK–μplasmin catalytic complex

description: Streptokinase (SK), a plasminogen activator (PA) that converts inactive plasminogen (Pg) to plasmin (Pm), is a protein secreted by groups A, C, and G <i>streptococci</i> (GAS, GCS, and GGS, respectively), with high sequence divergence and functional heterogeneity. While roles of some residual changes in altered SK functionality are shown, the underlying structural mechanisms are less known. Herein, using computational approaches, we analyzed the conformational basis for the increased activity of SK from a GGS (SKG132) isolate with four natural residual substitutions (Ile33Phe, Arg45Gln, Asn228Lys, Phe287Ile) compared to the standard GCS (SKC). Using the crystal structure of SK.Pm catalytic complex as main template SKC.μPm catalytic complex was modeled through homology modeling process and validated by several online validation servers. Subsequently, SKG132.μPm structure was constructed by altering the corresponding residual substitutions. Results of three independent MD simulations showed increased RMSF values for SKG132.μPm, indicating the enhanced structural flexibility compared to SKC.μPm, specially in 170 and 250 loops and three regions: R1 (149–161), R2 (182–215) and R3 (224–229). In parallel, the average number of Hydrogen bonds in 170 loop, R2 and R3 (especially for Asn228Lys) of SKG132 compared to that of the SKC was decreased. Accordingly, residue interaction networks (RINs) analyses indicated that Asn228Lys might induce more level of structural flexibility by generation of free Lys256, while Phe287Ile and Ile33Phe enhanced the stabilization of the SKG132.μPm catalytic complex. These results denoted the potential role of the optimal dynamic state and stabilized catalytic complex for increased PA potencies of SK as a thrombolytic drug.
DOI: 10.6084/m9.figshare.6374222.v1
title: Computational simulations assessment of mutations impact on streptokinase (SK) from a group G <i>streptococci</i> with enhanced activity – insights into the functional roles of structural dynamics flexibility of SK and stabilization of SK–μplasmin catalytic complex

description: Streptokinase (SK), a plasminogen activator (PA) that converts inactive plasminogen (Pg) to plasmin (Pm), is a protein secreted by groups A, C, and G <i>streptococci</i> (GAS, GCS, and GGS, respectively), with high sequence divergence and functional heterogeneity. While roles of some residual changes in altered SK functionality are shown, the underlying structural mechanisms are less known. Herein, using computational approaches, we analyzed the conformational basis for the increased activity of SK from a GGS (SKG132) isolate with four natural residual substitutions (Ile33Phe, Arg45Gln, Asn228Lys, Phe287Ile) compared to the standard GCS (SKC). Using the crystal structure of SK.Pm catalytic complex as main template SKC.μPm catalytic complex was modeled through homology modeling process and validated by several online validation servers. Subsequently, SKG132.μPm structure was constructed by altering the corresponding residual substitutions. Results of three independent MD simulations showed increased RMSF values for SKG132.μPm, indicating the enhanced structural flexibility compared to SKC.μPm, specially in 170 and 250 loops and three regions: R1 (149–161), R2 (182–215) and R3 (224–229). In parallel, the average number of Hydrogen bonds in 170 loop, R2 and R3 (especially for Asn228Lys) of SKG132 compared to that of the SKC was decreased. Accordingly, residue interaction networks (RINs) analyses indicated that Asn228Lys might induce more level of structural flexibility by generation of free Lys256, while Phe287Ile and Ile33Phe enhanced the stabilization of the SKG132.μPm catalytic complex. These results denoted the potential role of the optimal dynamic state and stabilized catalytic complex for increased PA potencies of SK as a thrombolytic drug.
DOI: 10.6084/m9.figshare.6374126
title: Conodont size reduction and diversity losses during the Carnian (Late Triassic) Humid Episode in SW China

description: Conodont length data from Long Chang (LC), Yongyue (NR) and Caizitang (CZ) sections and data of cross plot between estimated temperature and conodont mean size in the Long Chang section
DOI: 10.6084/m9.figshare.6374126.v1
title: Conodont size reduction and diversity losses during the Carnian (Late Triassic) Humid Episode in SW China

description: Conodont length data from Long Chang (LC), Yongyue (NR) and Caizitang (CZ) sections and data of cross plot between estimated temperature and conodont mean size in the Long Chang section
DOI: 10.6084/m9.figshare.6374078
title: Synthesis, antitumour activities and molecular docking of thiocarboxylic acid ester-based NSAID scaffolds: COX-2 inhibition and mechanistic studies

description: A new series of NSAID thioesters were synthesized and evaluated for their <i>in vitro</i> antitumor effects against a panel of four human tumor cell lines, namely: HepG2, MCF-7, HCT-116 and Caco-2, using the MTT assay. Compared to the reference drugs 5-FU, afatinib and celecoxib, compounds <b>2b</b>, <b>3b</b>, <b>6a</b>, <b>7a</b>, <b>7b</b> and <b>8a</b> showed potent broad-spectrum antitumor activity against the selected tumour cell lines. Accordingly, these compounds were selected for mechanistic studies about COX inhibition and kinase assays. <i>In vitro</i> COX-1/COX-2 enzyme inhibition assay results indicated that compounds <b>2b</b>, <b>3b</b>, <b>6a</b>, <b>7a</b>, <b>7b</b>, <b>8a</b> and <b>8 b</b> selectively inhibited the COX-2 enzyme (IC<sub>50</sub> = ∼0.20–0.69 μM), with SI values of (&gt;72.5–250) compared with celecoxib (IC<sub>50</sub> = 0.16 μM, COX-2 SI: &gt; 312.5); however, all the tested compounds did not inhibit the COX-1 enzyme (IC<sub>50</sub> &gt; 50 μM). On the other hand, EGFR, HER2, HER4 and cSrc kinase inhibition assays were evaluated at a 10 μM concentration. The selected candidates displayed limited activities against the various tested kinases; the compounds <b>2a</b>, <b>3b</b>, <b>6a</b>, <b>7a</b>, <b>7b</b> and <b>8a</b> showed no activity to weak activity (% inhibition = ∼0–10%). The molecular docking study revealed the importance of the thioester moiety for the interaction of the drugs with the amino acids in the active sites of COX-2. The aforementioned results indicated that thioester based on NSAID scaffolds derivatives may serve as new antitumor compounds.
DOI: 10.6084/m9.figshare.6374078.v1
title: Synthesis, antitumour activities and molecular docking of thiocarboxylic acid ester-based NSAID scaffolds: COX-2 inhibition and mechanistic studies

description: A new series of NSAID thioesters were synthesized and evaluated for their <i>in vitro</i> antitumor effects against a panel of four human tumor cell lines, namely: HepG2, MCF-7, HCT-116 and Caco-2, using the MTT assay. Compared to the reference drugs 5-FU, afatinib and celecoxib, compounds <b>2b</b>, <b>3b</b>, <b>6a</b>, <b>7a</b>, <b>7b</b> and <b>8a</b> showed potent broad-spectrum antitumor activity against the selected tumour cell lines. Accordingly, these compounds were selected for mechanistic studies about COX inhibition and kinase assays. <i>In vitro</i> COX-1/COX-2 enzyme inhibition assay results indicated that compounds <b>2b</b>, <b>3b</b>, <b>6a</b>, <b>7a</b>, <b>7b</b>, <b>8a</b> and <b>8 b</b> selectively inhibited the COX-2 enzyme (IC<sub>50</sub> = ∼0.20–0.69 μM), with SI values of (&gt;72.5–250) compared with celecoxib (IC<sub>50</sub> = 0.16 μM, COX-2 SI: &gt; 312.5); however, all the tested compounds did not inhibit the COX-1 enzyme (IC<sub>50</sub> &gt; 50 μM). On the other hand, EGFR, HER2, HER4 and cSrc kinase inhibition assays were evaluated at a 10 μM concentration. The selected candidates displayed limited activities against the various tested kinases; the compounds <b>2a</b>, <b>3b</b>, <b>6a</b>, <b>7a</b>, <b>7b</b> and <b>8a</b> showed no activity to weak activity (% inhibition = ∼0–10%). The molecular docking study revealed the importance of the thioester moiety for the interaction of the drugs with the amino acids in the active sites of COX-2. The aforementioned results indicated that thioester based on NSAID scaffolds derivatives may serve as new antitumor compounds.
DOI: 10.6084/m9.figshare.6373757
title: Data for Comparison of OTFS and OFDM in sub-6GHz and mmWave Line-of-Sight Mobility Channels

description: Data set for "Comparison of OTFS and OFDM in sub-6GHz and mmWave Line-of-Sight Mobility Channels"
DOI: 10.6084/m9.figshare.6373580
title: Suppression of respiratory growth defect of mutant deficient in mitochondrial phospholipase A<sub>1</sub> by overexpression of genes involved in coenzyme Q synthesis in <i>Saccharomyces cerevisiae</i>

description: <i>DDL1</i> encodes a mitochondrial phospholipase A<sub>1</sub> involved in acyl chain remodeling of mitochondrial phospholipids and degradation of cardiolipin in <i>Saccharomyces cerevisiae</i>. The deletion of <i>DDL1</i> leads to respiratory growth defects. To elucidate the physiological role of <i>DDL1</i>, we screened for genes that, when overexpressed, suppress the respiratory growth defect of the <i>DDL1</i> deletion mutant. Introduction of <i>COQ8, COQ9</i>, or <i>COQ5</i>, which are involved in coenzyme Q (CoQ) synthesis, using a multicopy vector suppressed the respiratory growth defect of the <i>DDL1</i> deletion mutant. In contrast, introduction of <i>COQ8</i> using a multicopy vector did not accelerate the growth of the deletion mutants of <i>TAZ1</i> or <i>CLD1</i>, which encode an acyltransferase or phospholipase A<sub>2</sub>, respectively, involved in the remodeling of cardiolipin. These results suggest genetic interactions between the mitochondrial phospholipase A<sub>1</sub> gene and the genes involved in CoQ synthesis. <b>Abbreviations</b>: CoQ: coenzyme Q; CL: cardiolipin; ORF: open reading frame; PA: phosphatidic acid; PC: phosphatidylcholine; PE: phosphatidylethanolamine; PG: phosphatidylglycerol; PLA1: phospholipase A1; iPLA1: intracellular PLA1; PLA2: phospholipase A2 Genetic interaction between <i>DDL1</i> encoding a mitochondrial phospholipase A<sub>1</sub> and genes involved in coenzyme Q synthesis.
DOI: 10.6084/m9.figshare.6373580.v1
title: Suppression of respiratory growth defect of mutant deficient in mitochondrial phospholipase A<sub>1</sub> by overexpression of genes involved in coenzyme Q synthesis in <i>Saccharomyces cerevisiae</i>

description: <i>DDL1</i> encodes a mitochondrial phospholipase A<sub>1</sub> involved in acyl chain remodeling of mitochondrial phospholipids and degradation of cardiolipin in <i>Saccharomyces cerevisiae</i>. The deletion of <i>DDL1</i> leads to respiratory growth defects. To elucidate the physiological role of <i>DDL1</i>, we screened for genes that, when overexpressed, suppress the respiratory growth defect of the <i>DDL1</i> deletion mutant. Introduction of <i>COQ8, COQ9</i>, or <i>COQ5</i>, which are involved in coenzyme Q (CoQ) synthesis, using a multicopy vector suppressed the respiratory growth defect of the <i>DDL1</i> deletion mutant. In contrast, introduction of <i>COQ8</i> using a multicopy vector did not accelerate the growth of the deletion mutants of <i>TAZ1</i> or <i>CLD1</i>, which encode an acyltransferase or phospholipase A<sub>2</sub>, respectively, involved in the remodeling of cardiolipin. These results suggest genetic interactions between the mitochondrial phospholipase A<sub>1</sub> gene and the genes involved in CoQ synthesis. <b>Abbreviations</b>: CoQ: coenzyme Q; CL: cardiolipin; ORF: open reading frame; PA: phosphatidic acid; PC: phosphatidylcholine; PE: phosphatidylethanolamine; PG: phosphatidylglycerol; PLA1: phospholipase A1; iPLA1: intracellular PLA1; PLA2: phospholipase A2 Genetic interaction between <i>DDL1</i> encoding a mitochondrial phospholipase A<sub>1</sub> and genes involved in coenzyme Q synthesis.
DOI: 10.6084/m9.figshare.6373145
title: Dataset (features extracted from chest CT images) accompanying the paper Automatic emphysema detection using weakly labeled HRCT lung images

description: The dataset contains derived features from CT images of patients and controls scanned at two different centers, Frederikshavn and Aalborg.Each image is represented by 50 feature vectors, where each feature vector describes a volumetric ROIs of size 41 x 41x 41 voxels, extracted at random locations inside the lung mask. The features extracted are Gaussian scale space features, or histograms of intensity values in the ROI after filtering the image. Here we use eight filters (smoothed image, gradient magnitude, Laplacian of Gaussian, three eigenvalues of the Hessian, Gaussian curvature and eigen magnitude), four scales (0.6, 1.2, 2.4 and 4.8 mm), and histograms of ten bins. <br>
DOI: 10.6084/m9.figshare.6373055
title: Datasets from Bumblebees distinguish floral scent patterns, and can transfer these to corresponding visual patterns

description: Excel file containing the datasets analysed in this manuscript – worksheets are labelled according to figure or analysis conducted
DOI: 10.6084/m9.figshare.6373055.v1
title: Datasets from Bumblebees distinguish floral scent patterns, and can transfer these to corresponding visual patterns

description: Excel file containing the datasets analysed in this manuscript – worksheets are labelled according to figure or analysis conducted
DOI: 10.6084/m9.figshare.6372908
title: Recent progress of metal–graphene

description: Metal–graphene nanostructures (NSs) as photocatalysts, prepared using simple and scalable synthesismethods, are gaining heightened attention as novel materials for water treatment and environmentalremediation applications. Graphene, the unique few layers sheet-like arrangement of sp2 hybridizedcarbon atoms, has an inimitable two-dimensional (2D) structure. The material is highly conductive, hashigh electron mobility and an extremely high surface area, and can be produced on a large scale at lowcost. Accordingly, it has been considered as an essential base component for producing various metalbasedNSs. In particular, metal-graphene NSs as photocatalysts have attracted considerable attention because of their special surface plasmon resonance (SPR) effect that can improve their performance for the removal of toxic dyes and other pollutants. This review summarizes the recent and advanced progress for the easy fabrication and design of graphene-based NSs as photocatalysts, as a novel tool, using a range of approaches, including green and biogenic approaches.
DOI: 10.6084/m9.figshare.6372908.v2
title: Recent progress of metal–graphene

description: Metal–graphene nanostructures (NSs) as photocatalysts, prepared using simple and scalable synthesismethods, are gaining heightened attention as novel materials for water treatment and environmentalremediation applications. Graphene, the unique few layers sheet-like arrangement of sp2 hybridizedcarbon atoms, has an inimitable two-dimensional (2D) structure. The material is highly conductive, hashigh electron mobility and an extremely high surface area, and can be produced on a large scale at lowcost. Accordingly, it has been considered as an essential base component for producing various metalbasedNSs. In particular, metal-graphene NSs as photocatalysts have attracted considerable attention because of their special surface plasmon resonance (SPR) effect that can improve their performance for the removal of toxic dyes and other pollutants. This review summarizes the recent and advanced progress for the easy fabrication and design of graphene-based NSs as photocatalysts, as a novel tool, using a range of approaches, including green and biogenic approaches.