cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.21856213.v1
title: The effects of agomelatine in cisplatin-induced toxicity on the kidney and liver tissues: In vivo study

description: Abstract Nephrotoxicity and hepatotoxicity are frequently seen adverse effects during cisplatin chemotherapy. In this study, we investigated the effects of agomelatine on cisplatin-induced toxicity in the kidney and liver. Animals were administered with a single dose of cisplatin (7 mg/kg, i.p.) and treated with agomelatine (20 and 40 mg/kg, p.o) for seven days. Renal and hepatic functions were evaluated by measuring concentrations of creatinine, BUN, AST and ALT in the serum. Oxidative stress and protein peroxidation were assessed by measuring SOD, CAT, GSH and AOPP levels in both tissues. Serum PON-1 levels were also evaluated. Histopathological analysis was performed to determined structural changes in the kidney and liver. Agomelatine (20 mg/kg) treatment approximately halved cisplatin-related increase in serum creatinine, BUN, AST and ALT levels. Agomelatine (20 mg/kg) significantly prevented the cisplatin-induced excessive decrease in SOD, CAT, GSH in both tissues and serum PON-1 levels. Agomelatine (20 and 40 mg/kg) protected the structural integrity of the kidney against cisplatin-insult. Although agomelatine (40 mg/kg) protected the kidney and showed parallel results with 20 mg/kg biochemically, it failed to show the same liver tissue effects in both analyses. Although agomelatine protected against cisplatin-induced toxicity in the kidney and liver, care should be taken with higher doses for possible hepatotoxicity.
DOI: 10.6084/m9.figshare.21856215
title: Mapping community pharmacy services in Brazil: a scoping review

description: Abstract The delivery of clinical pharmacy services has been growing in Brazilian community pharmacies, and it is necessary to have a comprehensive understanding of the topic. This scoping review aimed to provide an overview of Brazilian studies about clinical pharmacy services in community pharmacies. Original research articles, with no restriction of time, study design, or patient’s health condition, were included. Searches were conducted in PubMed, Scopus, Web of Science, Scielo, and Lilacs. Two reviewers conducted the screening, full-text reading, and data extraction independently. ROB and ROBINS-I were used for the assessment of quality. Charts and tables were built to summarise the data. Seventy-two articles were included. A diversity of study designs, number of participants, terms used, and outcomes was found. São Paulo and Sergipe States had the highest number of studies (n=10). Pharmacists’ interventions were not fully reported in 65% of studies, and most studies presented an unclear risk of bias. Studies were very diverse, impairing the comparisons between the results and hindering their reproducibility. This review suggests using guidelines and checklists for better structuration of pharmacists’ interventions as well as reporting results and measuring fidelity in future research.
DOI: 10.6084/m9.figshare.21856215.v1
title: Mapping community pharmacy services in Brazil: a scoping review

description: Abstract The delivery of clinical pharmacy services has been growing in Brazilian community pharmacies, and it is necessary to have a comprehensive understanding of the topic. This scoping review aimed to provide an overview of Brazilian studies about clinical pharmacy services in community pharmacies. Original research articles, with no restriction of time, study design, or patient’s health condition, were included. Searches were conducted in PubMed, Scopus, Web of Science, Scielo, and Lilacs. Two reviewers conducted the screening, full-text reading, and data extraction independently. ROB and ROBINS-I were used for the assessment of quality. Charts and tables were built to summarise the data. Seventy-two articles were included. A diversity of study designs, number of participants, terms used, and outcomes was found. São Paulo and Sergipe States had the highest number of studies (n=10). Pharmacists’ interventions were not fully reported in 65% of studies, and most studies presented an unclear risk of bias. Studies were very diverse, impairing the comparisons between the results and hindering their reproducibility. This review suggests using guidelines and checklists for better structuration of pharmacists’ interventions as well as reporting results and measuring fidelity in future research.
DOI: 10.6084/m9.figshare.21856221
title: Anti urolithiatic activity of Cyperus rotundus tubers: In silico, In vitro and In vivo approaches

description: Abstract The present research evaluated the anti urolithic potential of Cyperus rotundus tubers extract using in silico, in vitro and in vivo techniques. In silicostudy was performed of Cyperus rotundus constituents and pathological protein oxalate oxidase (PDB Id: 2ETE). In vitrostudy, nucleation and aggregation assay involved for assessment of ethanol extract of Cyperus rotundus tuber (50-3000 µg/ml).In vivo studies involved that the Cyperus rotundusethanolic extract (100, 200 and 400 mg/kg B.wt.) wastreatedonsodium oxalate induced urolithiatic rats for seven days,evaluated kidney function by urine and serum biochemical analysis and statistical analysis performed usingGraphPad prism5 software.In silico results showedthat Cyperus rotundus constituents,Humulene epoxide, 4-Oxo-alpha-ylangene, Cubebol were exhibited better binding energyonoxalate oxidase.Ethanolic extract of Cyperus rotundustuber was exhibited nucleation, aggregation of calcium oxalate monohydrate crystals inhibition in dosedependent manner. Sodium oxalate treatment was triggered biochemical changesin the urine that have been substantially prevented by the ethanolic extract of Cyperus rotundus tuber. The current findings Cyperus rotundus anti urolithic activity due to antioxidant essential oils. The molecular docking results could be used to optimize lead and develop the appropriate urolithiasis treatment.
DOI: 10.6084/m9.figshare.21856221.v1
title: Anti urolithiatic activity of Cyperus rotundus tubers: In silico, In vitro and In vivo approaches

description: Abstract The present research evaluated the anti urolithic potential of Cyperus rotundus tubers extract using in silico, in vitro and in vivo techniques. In silicostudy was performed of Cyperus rotundus constituents and pathological protein oxalate oxidase (PDB Id: 2ETE). In vitrostudy, nucleation and aggregation assay involved for assessment of ethanol extract of Cyperus rotundus tuber (50-3000 µg/ml).In vivo studies involved that the Cyperus rotundusethanolic extract (100, 200 and 400 mg/kg B.wt.) wastreatedonsodium oxalate induced urolithiatic rats for seven days,evaluated kidney function by urine and serum biochemical analysis and statistical analysis performed usingGraphPad prism5 software.In silico results showedthat Cyperus rotundus constituents,Humulene epoxide, 4-Oxo-alpha-ylangene, Cubebol were exhibited better binding energyonoxalate oxidase.Ethanolic extract of Cyperus rotundustuber was exhibited nucleation, aggregation of calcium oxalate monohydrate crystals inhibition in dosedependent manner. Sodium oxalate treatment was triggered biochemical changesin the urine that have been substantially prevented by the ethanolic extract of Cyperus rotundus tuber. The current findings Cyperus rotundus anti urolithic activity due to antioxidant essential oils. The molecular docking results could be used to optimize lead and develop the appropriate urolithiasis treatment.
DOI: 10.6084/m9.figshare.21856222
title: Anisotropic elastic applications in composite materials using the isogeometric boundary element method

description: Abstract This paper describes an isogeometric analysis of the boundary element method, called IGABEM, applied to anisotropic 2D plane elastic problems. The Lekhnitskii's anisotropic fundamental solution is used and the singular integral terms is regularized. For the weak singularity kernel, the Telles transform is used. On the other hand, in the strong singularity term, the Singularity Subtraction Technique - SST is used. The shape functions used are the Non-Uniform Rational B-Spline - NURBS. Thus, the same mathematical representation of Computer Aided Design - CAD is used in the implemented computational code. This avoids the generation of meshes and provides an exact representation of most complex geometries. As a reflection of this isoparametric concept, errors from geometric interpolation are excluded, improving numerical results. Furthermore, to increase the numerical efficiency of the code, the NURBS are decomposed into Bézier curves. To evaluate the accuracy of the formulation, complex problems using high-order isogeometric boundary elements are analyzed. Their results are compared to analytical solutions showing good agreement.
DOI: 10.6084/m9.figshare.21856222.v1
title: Anisotropic elastic applications in composite materials using the isogeometric boundary element method

description: Abstract This paper describes an isogeometric analysis of the boundary element method, called IGABEM, applied to anisotropic 2D plane elastic problems. The Lekhnitskii's anisotropic fundamental solution is used and the singular integral terms is regularized. For the weak singularity kernel, the Telles transform is used. On the other hand, in the strong singularity term, the Singularity Subtraction Technique - SST is used. The shape functions used are the Non-Uniform Rational B-Spline - NURBS. Thus, the same mathematical representation of Computer Aided Design - CAD is used in the implemented computational code. This avoids the generation of meshes and provides an exact representation of most complex geometries. As a reflection of this isoparametric concept, errors from geometric interpolation are excluded, improving numerical results. Furthermore, to increase the numerical efficiency of the code, the NURBS are decomposed into Bézier curves. To evaluate the accuracy of the formulation, complex problems using high-order isogeometric boundary elements are analyzed. Their results are compared to analytical solutions showing good agreement.
DOI: 10.6084/m9.figshare.21856225
title: Cytotoxic activity of extracts from Tecoma species and isolated lignans

description: Abstract A phytochemical study of Tecoma genus (Bignoniaceae) was accomplished by antitumor activity of ethanolic extracts. Species of this genus are composed of small shrubs often used as ornamental plants. The Tecoma stans species is used in folk medicine for different purposes. Recent work shows in vitro anticancer activity against human breast cancer. The ethanolic extracts from leaves and trunks of Tecoma casneifolia, T. garrocha, T. stans var. angustata and T. stans var. stans were tested in vitro. The assays used were against line tumor cells by the MTT method and the most active extracts were further studied. In this way, the ethanolic extract from T. stans var. stans trunks presented the higher cytotoxicity against the tumor cell lines studied (CC50 0.02 to 0.55 µg/ml) when compared to the other extracts tested (CC50 0.08 to 200.0 µg/ml). Accordingly, this extract was selected for chromatographic fractionation from which five known lignans were isolated. Further, paulownin, paulownin acetate, sesamin, olivil and cycloolivil were identified using 13C and 1H NMR, IR, UV and spectroscopy and spectrometric MS techniques. These isolated compounds were tested and exhibited CC50 ranging from 13.01 to100.0 µg/ml which is superior to the ethanolic extract of trunk of T. stans.
DOI: 10.6084/m9.figshare.21856225.v1
title: Cytotoxic activity of extracts from Tecoma species and isolated lignans

description: Abstract A phytochemical study of Tecoma genus (Bignoniaceae) was accomplished by antitumor activity of ethanolic extracts. Species of this genus are composed of small shrubs often used as ornamental plants. The Tecoma stans species is used in folk medicine for different purposes. Recent work shows in vitro anticancer activity against human breast cancer. The ethanolic extracts from leaves and trunks of Tecoma casneifolia, T. garrocha, T. stans var. angustata and T. stans var. stans were tested in vitro. The assays used were against line tumor cells by the MTT method and the most active extracts were further studied. In this way, the ethanolic extract from T. stans var. stans trunks presented the higher cytotoxicity against the tumor cell lines studied (CC50 0.02 to 0.55 µg/ml) when compared to the other extracts tested (CC50 0.08 to 200.0 µg/ml). Accordingly, this extract was selected for chromatographic fractionation from which five known lignans were isolated. Further, paulownin, paulownin acetate, sesamin, olivil and cycloolivil were identified using 13C and 1H NMR, IR, UV and spectroscopy and spectrometric MS techniques. These isolated compounds were tested and exhibited CC50 ranging from 13.01 to100.0 µg/ml which is superior to the ethanolic extract of trunk of T. stans.
DOI: 10.6084/m9.figshare.21856228
title: Antioxidant profile of hot and sweet pepper cultivars by two extraction methods

description: ABSTRACT Chili peppers are among the most important vegetables in the world. The demand of this fruit reveals a noticeable rapid increasing, which importance is mainly due to its nutraceutical composition. These fruits are rich in capsaicinoids, phenolic compounds, carotenoids, and others, including vitamins. In this study, a comparative evaluation between two extraction methods of bioactive compounds of fourteen chili pepper cultivars was performed. Two extraction methods for antioxidants, the time-solvent and the ultrasound were evaluated. The design of the experiment was completely randomized with three repetitions where variables evaluated were total phenolic compounds, flavonoids content, antioxidant capacity and capsaicin. Results showed that the phenolic compounds oscillated between 48.7 - 634.1 mg GAE/100 g dry weight (DW), the flavonoids content varied from 1 - 97 mg QE/100 g DW, the antioxidant activity from 65 - 348 µmol Trolox/g DW and the capsaicin content oscillated from 0.3 - 922 mg/100 g DW. The extraction method with higher values of bioactive compounds for each of the chili pepper types was the ultrasound for all the measured variables.
DOI: 10.6084/m9.figshare.21856228.v1
title: Antioxidant profile of hot and sweet pepper cultivars by two extraction methods

description: ABSTRACT Chili peppers are among the most important vegetables in the world. The demand of this fruit reveals a noticeable rapid increasing, which importance is mainly due to its nutraceutical composition. These fruits are rich in capsaicinoids, phenolic compounds, carotenoids, and others, including vitamins. In this study, a comparative evaluation between two extraction methods of bioactive compounds of fourteen chili pepper cultivars was performed. Two extraction methods for antioxidants, the time-solvent and the ultrasound were evaluated. The design of the experiment was completely randomized with three repetitions where variables evaluated were total phenolic compounds, flavonoids content, antioxidant capacity and capsaicin. Results showed that the phenolic compounds oscillated between 48.7 - 634.1 mg GAE/100 g dry weight (DW), the flavonoids content varied from 1 - 97 mg QE/100 g DW, the antioxidant activity from 65 - 348 µmol Trolox/g DW and the capsaicin content oscillated from 0.3 - 922 mg/100 g DW. The extraction method with higher values of bioactive compounds for each of the chili pepper types was the ultrasound for all the measured variables.
DOI: 10.6084/m9.figshare.21856230.v1
title: Undergraduate students’ academic socialization at a public research university: variations of student experience in relation to cultural capital

description: ABSTRACT This article explores which factors contribute to academic socialization among a group of possible components of this process. The topic is set in the context of expansion and diversification of student audiences in Brazilian public universities beyond social groups with high cultural capital. To analyze the academic socialization of university students, a scale was elaborated, composed of sections covering: academic activities prioritized in the student experience; valuation of learning; and difficulties expressed by students. Context variables were also analyzed. This is an exploratory study, with a quantitative approach that employs descriptive analyses, analyzing mean comparisons and correlations. The analyzed data were obtained from 1,185 responses to a survey applied in 2021 among undergraduate students at the Federal University of Rio Grande do Sul. The results indicate a more intense academic socialization among students who participated in extracurricular academic programs. Converging with recent sociological literature, there are cases of high academic socialization related to traditional indicators of cultural capital. However, other training experiences available to students of unprivileged social origins, such as extracurricular programs of research, extension, and teaching apprenticeship, were shown to also lead to higher intensity of academic socialization. Data interpretation suggests that institutional investment in such programs and in the dialogue with the various forms of cultural capital developed by the students may produce better fruition of the university experience.
DOI: 10.6084/m9.figshare.21856230
title: Undergraduate students’ academic socialization at a public research university: variations of student experience in relation to cultural capital

description: ABSTRACT This article explores which factors contribute to academic socialization among a group of possible components of this process. The topic is set in the context of expansion and diversification of student audiences in Brazilian public universities beyond social groups with high cultural capital. To analyze the academic socialization of university students, a scale was elaborated, composed of sections covering: academic activities prioritized in the student experience; valuation of learning; and difficulties expressed by students. Context variables were also analyzed. This is an exploratory study, with a quantitative approach that employs descriptive analyses, analyzing mean comparisons and correlations. The analyzed data were obtained from 1,185 responses to a survey applied in 2021 among undergraduate students at the Federal University of Rio Grande do Sul. The results indicate a more intense academic socialization among students who participated in extracurricular academic programs. Converging with recent sociological literature, there are cases of high academic socialization related to traditional indicators of cultural capital. However, other training experiences available to students of unprivileged social origins, such as extracurricular programs of research, extension, and teaching apprenticeship, were shown to also lead to higher intensity of academic socialization. Data interpretation suggests that institutional investment in such programs and in the dialogue with the various forms of cultural capital developed by the students may produce better fruition of the university experience.
DOI: 10.6084/m9.figshare.21856237
title: A study on diabetes-related self-care plan and its determinants among diabetes patients in a Warangal region, Telangana, India

description: Abstract The prevalence of epidemiological diseases, including diabetes, has continued to increase because of the adaption of Western culture and the lack of self-care activities among patients with diabetes. Therefore, in this cross-sectional study, we aimed to assess self-care plans and determinants among diabetes outpatients in Warangal. We conducted a prospective observational study among diabetes outpatient clinic in Warangal, India over 6 months from October 2019 to March 2020. We used the expanded Summary of Diabetes Self-Care Activities (SDSCA) questionnaire. A P value of less than &lt; 0.05 was considered statistically significant. Respondents (mean age, 52.3 (standard deviation (SD), 11.01) years) had an overall SDSCA score of 49.18 ± 3.57 (SD). Mean scores for the diet, physical activity, foot care, medication adherence, and blood sugar testing scales were 12.79 (SD, 1.61), 10.24 (SD, 1.77), 15.67 (SD, 1.5), 5.66 (SD, 1.17), and 4.80 (SD, 0.68), respectively. Patients’ age, education, disease duration and hemoglobin A1C (HbA1C) levels of &lt;7.5% (P &lt; 0.001)) had significantly higher mean scores for blood sugar testing, diet, physical activity, and adherence (P &lt; 0.001). The employment status is associated with all the domains of Summary of Diabetes Self-Care Activities (P &lt; 0.001). Taken together, our results revealed that patients with diabetes in Warangal had poor self-care planning, highlighting the need for strengthening initiatives that generate awareness regarding diabetes and improving related self-care practices.
DOI: 10.6084/m9.figshare.21856237.v1
title: A study on diabetes-related self-care plan and its determinants among diabetes patients in a Warangal region, Telangana, India

description: Abstract The prevalence of epidemiological diseases, including diabetes, has continued to increase because of the adaption of Western culture and the lack of self-care activities among patients with diabetes. Therefore, in this cross-sectional study, we aimed to assess self-care plans and determinants among diabetes outpatients in Warangal. We conducted a prospective observational study among diabetes outpatient clinic in Warangal, India over 6 months from October 2019 to March 2020. We used the expanded Summary of Diabetes Self-Care Activities (SDSCA) questionnaire. A P value of less than &lt; 0.05 was considered statistically significant. Respondents (mean age, 52.3 (standard deviation (SD), 11.01) years) had an overall SDSCA score of 49.18 ± 3.57 (SD). Mean scores for the diet, physical activity, foot care, medication adherence, and blood sugar testing scales were 12.79 (SD, 1.61), 10.24 (SD, 1.77), 15.67 (SD, 1.5), 5.66 (SD, 1.17), and 4.80 (SD, 0.68), respectively. Patients’ age, education, disease duration and hemoglobin A1C (HbA1C) levels of &lt;7.5% (P &lt; 0.001)) had significantly higher mean scores for blood sugar testing, diet, physical activity, and adherence (P &lt; 0.001). The employment status is associated with all the domains of Summary of Diabetes Self-Care Activities (P &lt; 0.001). Taken together, our results revealed that patients with diabetes in Warangal had poor self-care planning, highlighting the need for strengthening initiatives that generate awareness regarding diabetes and improving related self-care practices.
DOI: 10.6084/m9.figshare.21856240
title: Association between disease activity and quality of life among patients with rheumatoid arthritis

description: Abstract The aim of this study is the association between the scores of disease activity, functional capacity and quality of life among patients diagnosed with rheumatoid arthritis, under clinical treatment at the Regional University Hospital of Campos Gerais - Wallace Thadeu de Mello and Silva. The sample was composed by volunteer patients, who freely underwent 3 research questionnaires. With the results of the survey, the disease activity score was correlated to the functional capacity and the quality-of-life scores. A mean of 3.87 and 1.2 was observed for the disease activity and the functional capacity scores, respectively, yet not achieving a correlation between those two variables. A strong correlation between the disease activity and the “functional capacity”, “general health status” and “mental health” domains was found. The lowest average observed corresponded to “physical limitation”, from the quality-of-life questionnaire. There was no statistically significant correlation between disease activity and functional capacity, although disease activity seems to affect the mental health, general health status and functional capacity of patients.