cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.14545536.v1
title: Supplementary Material for: Progression in Physical Frailty in Peritoneal Dialysis Patients

description: <b><i>Background:</i></b> Physical frailty contributes to adverse clinical outcomes in peritoneal dialysis (PD) patients. Little has been reported about frailty transitions in this population. We aimed to describe the transitions of frailty in PD patients and identify factors that predicted changes in frailty state. <b><i>Methods:</i></b> In a prospective observational study, we recruited 267 PD patients. Frailty was assessed by a validated frailty score. Depression was graded by PHQ-9 score, and nutritional status was evaluated by serum albumin, Subjective Global Assessment (SGA), and comprehensive Malnutrition Inflammation Score (MIS). The primary outcome was the change in frailty score at follow-up compared to baseline. <b><i>Results:</i></b> At baseline, 194 (72.7%) patients were classified as frail. With time, their frailty scores significantly increased (<i>p</i> &lt; 0.001), and 93 of the surviving subjects (78.2%) were classified as frail. There was a modest significant correlation between change in MIS (<i>p</i> &lt; 0.001), change in SGA score (<i>p</i> &lt; 0.001), and change in PHQ-9 score (<i>p</i> &lt; 0.001) with change in frailty score. An increase in PHQ-9 score (<i>p</i> &lt; 0.001) and MIS (<i>p</i> = 0.001), as well as longer duration of hospitalization (<i>p</i> = 0.001), was independently associated with a greater change in frailty score after adjustment for confounding factors. Frailty score was also improved in patients who were converted to hemodialysis (<i>p</i> = 0.048) and received renal transplantation (<i>p</i> = 0.005). <b><i>Conclusion:</i></b> Our findings suggested that frailty transitions were common in PD patients. Worsening in nutrition and depression, together with a longer duration of hospitalization, were associated with worsening in frailty.
DOI: 10.6084/m9.figshare.14545479
title: Supplementary Material for: Deciphering the Pathogenic Nature of Two de novo Sequence Variations in a Patient with Shprintzen-Goldberg Syndrome

description: Shprintzen-Goldberg syndrome (SGS) is autosomal dominant disorder with features of craniosynostosis, distinctive craniofacial features, skeletal abnormalities, marfanoid body habitus, aortic dilatation, and intellectual disability. SGS is caused by mutations in the <i>SKI</i> gene, encoding the oncoprotein SKI, a repressor of TGFβ activity. We present the unusual molecular findings in a 12-year-old female child with SGS. There was co-occurrence of 2 heterozygous missense variations, c.346G&gt;A (p.Gly116Arg) and c.687G&gt;C (p.Lys229Asn), in exon 1 (hotspot) of the <i>SKI</i> gene, which makes this propositus different from all other patients reported in the literature. Both variants were found to be de novo. In silico analysis revealed that both of them are pathogenic, but later on, Gly116Arg was proven to be more pathogenic by various in silico prediction tools. c.687G&gt;C (p.Lys229Asn) was found as a single report in ExAC in the South Asian population, but c.346G&gt;A (p.Gly116Arg) is not reported anywhere, thereby making it a novel sequence variant in the <i>SKI</i> gene, giving rise to SGS. This case illustrates the issues regarding the importance and difficulties associated with the determination of the causative variations in a single-gene disorder.
DOI: 10.6084/m9.figshare.14545479.v1
title: Supplementary Material for: Deciphering the Pathogenic Nature of Two de novo Sequence Variations in a Patient with Shprintzen-Goldberg Syndrome

description: Shprintzen-Goldberg syndrome (SGS) is autosomal dominant disorder with features of craniosynostosis, distinctive craniofacial features, skeletal abnormalities, marfanoid body habitus, aortic dilatation, and intellectual disability. SGS is caused by mutations in the <i>SKI</i> gene, encoding the oncoprotein SKI, a repressor of TGFβ activity. We present the unusual molecular findings in a 12-year-old female child with SGS. There was co-occurrence of 2 heterozygous missense variations, c.346G&gt;A (p.Gly116Arg) and c.687G&gt;C (p.Lys229Asn), in exon 1 (hotspot) of the <i>SKI</i> gene, which makes this propositus different from all other patients reported in the literature. Both variants were found to be de novo. In silico analysis revealed that both of them are pathogenic, but later on, Gly116Arg was proven to be more pathogenic by various in silico prediction tools. c.687G&gt;C (p.Lys229Asn) was found as a single report in ExAC in the South Asian population, but c.346G&gt;A (p.Gly116Arg) is not reported anywhere, thereby making it a novel sequence variant in the <i>SKI</i> gene, giving rise to SGS. This case illustrates the issues regarding the importance and difficulties associated with the determination of the causative variations in a single-gene disorder.
DOI: 10.17909/t9-bmkf-m360
title: HST Data Cycle26
DOI: 10.17909/t9-2cc8-8s52
title: HST Data Cycle25
DOI: 10.5281/zenodo.2648855
title: Datasets for "The Equatorial Undercurrent and the Oxygen Minimum Zone in the Pacific"; GRL, under review.

description: Selected datasets to reproduce results from "The Equatorial Undercurrent and the Oxygen Minimum Zone in the Pacific" (currently under review)
DOI: 10.5281/zenodo.2648591
title: Datasets for "The Equatorial Undercurrent and the Oxygen Minimum Zone in the Pacific"; GRL, under review.

description: Selected datasets to reproduce results from "The Equatorial Undercurrent and the Oxygen Minimum Zone in the Pacific" (currently under review)
DOI: 10.6084/m9.figshare.14545725
title: Supplementary Material for: Long-term Treatment with Telotristat Ethyl in Patients with Carcinoid Syndrome Symptoms: Results from the TELEPATH Study

description: Medicine
DOI: 10.6084/m9.figshare.14545725.v1
title: Supplementary Material for: Long-term Treatment with Telotristat Ethyl in Patients with Carcinoid Syndrome Symptoms: Results from the TELEPATH Study

description: Medicine
DOI: 10.5517/ccdc.csd.cc23633k
title: CCDC 1942277: Experimental Crystal Structure Determination

description: Related Article: Santu Bera, Xuewei Dong, Bankala Krishnarjuna, Shannon A. Raab, David A. Hales, Wei Ji, Yiming Tang, Linda J.W. Shimon, Ayyalusamy Ramamoorthy, David E. Clemmer, Guanghong Wei, Ehud Gazit|2021|Cell Reports Physical Science|2|100391|doi:10.1016/j.xcrp.2021.100391
DOI: 10.5517/ccdc.csd.cc244frh
title: CCDC 1970476: Experimental Crystal Structure Determination

description: Related Article: Pavel A. Petrov, Taisiya S. Sukhikh, Vladimir A. Nadolinny, Maxim A. Mikhaylov, Alexander N. Lavrov, Alexey A. Dmitriev, Nina P. Gritsan, Maxim N. Sokolov|2021|Inorg.Chem.|60|6746|doi:10.1021/acs.inorgchem.1c00568
DOI: 10.5517/ccdc.csd.cc244fsj
title: CCDC 1970477: Experimental Crystal Structure Determination

description: Related Article: Pavel A. Petrov, Taisiya S. Sukhikh, Vladimir A. Nadolinny, Maxim A. Mikhaylov, Alexander N. Lavrov, Alexey A. Dmitriev, Nina P. Gritsan, Maxim N. Sokolov|2021|Inorg.Chem.|60|6746|doi:10.1021/acs.inorgchem.1c00568
DOI: 10.5517/ccdc.csd.cc24f9lh
title: CCDC 1978996: Experimental Crystal Structure Determination

description: Related Article: Xiao-Lei Zhao, Min Wang, Jiao Geng, Wei Huang|2021|Polyhedron|202|115208|doi:10.1016/j.poly.2021.115208
DOI: 10.5517/ccdc.csd.cc24f9mj
title: CCDC 1978997: Experimental Crystal Structure Determination

description: Related Article: Xiao-Lei Zhao, Min Wang, Jiao Geng, Wei Huang|2021|Polyhedron|202|115208|doi:10.1016/j.poly.2021.115208
DOI: 10.5517/ccdc.csd.cc24f9nk
title: CCDC 1978998: Experimental Crystal Structure Determination

description: Related Article: Xiao-Lei Zhao, Min Wang, Jiao Geng, Wei Huang|2021|Polyhedron|202|115208|doi:10.1016/j.poly.2021.115208
DOI: 10.5517/ccdc.csd.cc26rv94
title: CCDC 2048706: Experimental Crystal Structure Determination

description: Related Article: Peter Viereck, Stephan M. Rummelt, Natalia A. Soja, Tyler P. Pabst, Paul J. Chirik|2021|Organometallics|40|1053|doi:10.1021/acs.organomet.1c00046
DOI: 10.5517/ccdc.csd.cc26rvb5
title: CCDC 2048707: Experimental Crystal Structure Determination

description: Related Article: Peter Viereck, Stephan M. Rummelt, Natalia A. Soja, Tyler P. Pabst, Paul J. Chirik|2021|Organometallics|40|1053|doi:10.1021/acs.organomet.1c00046
DOI: 10.5517/ccdc.csd.cc26rvc6
title: CCDC 2048708: Experimental Crystal Structure Determination

description: Related Article: Peter Viereck, Stephan M. Rummelt, Natalia A. Soja, Tyler P. Pabst, Paul J. Chirik|2021|Organometallics|40|1053|doi:10.1021/acs.organomet.1c00046
DOI: 10.5517/ccdc.csd.cc26v9gv
title: CCDC 2051067: Experimental Crystal Structure Determination

description: Related Article: Radu Custelcean, Kathleen A. Garrabrant, Pierrick Agullo, Neil J. Williams|2021|Cell Reports Physical Science|2|100385|doi:10.1016/j.xcrp.2021.100385
DOI: 10.5517/ccdc.csd.cc274n24
title: CCDC 2060045: Experimental Crystal Structure Determination

description: Related Article: Xue-Zhen Zhang, Wei-Hui Fang, Xiao-Feng Wang|2021|Inorg.Chem.Commun.|128|108608|doi:10.1016/j.inoche.2021.108608
DOI: 10.5517/ccdc.csd.cc274n35
title: CCDC 2060046: Experimental Crystal Structure Determination

description: Related Article: Xue-Zhen Zhang, Wei-Hui Fang, Xiao-Feng Wang|2021|Inorg.Chem.Commun.|128|108608|doi:10.1016/j.inoche.2021.108608
DOI: 10.6084/m9.figshare.14545752
title: Supplementary Material for: Comparative Efficacy of Atezolizumab plus Bevacizumab and Other Treatment Options for Patients with Unresectable Hepatocellular Carcinoma: A Network Meta-Analysis

description: <b><i>Background:</i></b> Most phase 3 clinical trials of systemic therapy for first-line unresectable hepatocellular carcinoma (HCC) have failed, with the exception of SHARP, REFLECT, and IMbrave150. We conducted indirect comparisons of therapies evaluated for first-line HCC treatment. <b><i>Summary:</i></b> We conducted a systematic review and meta-analysis of treatments for adults with locally advanced or metastatic unresectable HCC and no prior systemic treatment, including atezolizu­mab plus bevacizumab, sorafenib, lenvatinib, nivolumab, selective internal radiotherapy (SIRT), transarterial chemoembolization, and placebo or best supportive care. Randomized controlled trials published from January 1, 2007, to March 12, 2020, were retrieved from MEDLINE and Embase. Qualitative assessment of heterogeneity evaluated study designs, populations, and outcomes. Indirect comparisons used generalized linear models with random effects within a Bayesian framework and informative priors. We calculated relative efficacy estimates with 95% credible intervals (CrIs) and Bayesian posterior probability estimates of atezolizumab-bevacizumab being superior to other treatments. Nine clinical studies with a total of 3,897 participants were identified from 8,783 records and used to build the all-trials evidence network. Indirect comparisons suggested an improved overall survival (OS) with atezolizumab-bevacizumab versus lenvatinib (odds ratio, 0.63 [95% CrI 0.39–1.04]; with 97% Bayesian posterior probability of being superior), nivolumab (0.68 [95% CrI 0.41–1.14]; 94%), sorafenib (0.59 [95% CrI 0.39–0.87]; 99%), SIRT (0.51 [95% CrI 0.32–0.82]; 100%), or placebo/best supportive care (0.40 [95% CrI 0.25–0.64]; 100%). <b><i>Key Messages:</i></b> Within the context of indirect comparisons, analyses of OS favored atezolizumab-bevacizumab versus other treatment options for patients with locally advanced or metastatic unresectable HCC.
DOI: 10.5278/bf9d4464-c2e7-4c58-8c23-107fd93b7224
title: Ekstra analyser af omkostningseffektiviteten af Domiciliary High Flow Nasal Cannula behandling til KOL patienter med kronisk respirationssvigt
title: Additional analyses of Cost-effectiveness of Domiciliary High Flow Nasal Cannula treatment in COPD patients with chronic respiratory failure
DOI: 10.6084/m9.figshare.14503853.v1
title: Poly-SUMO-2/3 chain modification of Nuf2 facilitates CENP-E kinetochore localization and chromosome congression during mitosis

description: SUMO modification is required for the kinetochore localization of the kinesin-like motor protein CENP-E, which subsequently mediates the alignment of chromosomes to the spindle equator during mitosis. However, the underlying mechanisms by which sumoylation regulates CENP-E kinetochore localization are still unclear. In this study, we first elucidate that the kinetochore protein Nuf2 is not only required for CENP-E kinetochore localization but also preferentially modified by poly-SUMO-2/3 chains. In addition, poly-SUMO-2/3 modification of Nuf2 is significantly upregulated during mitosis, which is temporally correlated to the kinetochore localization of CENP-E during mitosis. We further show that the mitotic defects in CENP-E kinetochore localization and chromosome congression caused by global inhibition of sumoylation can be rescued by expressing a fusion protein between Nuf2 and the SUMO-conjugating enzyme Ubc9 for stimulating Nuf2 SUMO-2/3 modification. Moreover, the expression of another fusion protein between Nuf2 and three SUMO-2 moieties (SUMO-2 trimer), which mimics the trimeric SUMO-2/3 chain modification of Nuf2, can also rescue the mitotic defects due to global inhibition of sumoylation. Conversely, expressing the other forms of Nuf2-SUMO fusion proteins, which imitate Nuf2 modifications by SUMO-2/3 monomer, SUMO-2/3 dimer, and SUMO-1 trimer, respectively, cannot rescue the same mitotic defects. Lastly, compared to Nuf2, the fusion protein simulating the trimeric SUMO-2 chain-modified Nuf2 exhibits a significantly higher binding affinity to CENP-E wild type containing a functional SUMO-interacting motif (SIM) but not the CENP-E SIM mutant. Hence, our results support a model that poly-SUMO-2/3 chain modification of Nuf2 facilitates CENP-E kinetochore localization and chromosome congression during mitosis. <b>Abbreviations</b>: CENP-E, centromere-associated protein E; SUMO, small ubiquitin-related modifier; SIM, SUMO-interacting motif.
DOI: 10.15151/esrf-es-406352178
title: Structural organisation of artificial water channels

description: We propose to use GISAX and X-ray reflectometry measurements to characterise the structural organisation of artificial water channels in a planar lipid bilayer formed by a set of molecules (I-quartet imidazole) that have demonstrated to have high transport potentiality and ionic selectivity. These molecules aim to mimic natural aquaporine-like behaviour, and have strong technological potentiality in the field of water purification, for example. The experiments are intended to support and complement the past experimental and computational characterisations. The ultimate goal is to unveil the correlation among the fine structural in-membrane organisation and transport properties in order to understand the microscopic mechanism of water flow. Such an understanding will favor further chemical design and optimisation of these novel artificial water channels.
DOI: 10.17632/6m5r6f2z5g.1
title: DEFORM material database of AISI-316 steel at [-200-1100C]

description: DEFORM material database of AISI-316 steel at [-200-1100C]
DOI: 10.17632/r39n8sxyzr.6
title: The duality of poverty: A replication of Mani et al. (2013)

description: To replicate the results, download all files from the /input folder. If necessary, create the /input and /output folder locally on your computer. Then download the .Rmd file and run all the script.
DOI: 10.17632/mdjckk34r8.1
title: Data for: Impacts of temporal changes in land use/cover on the remaining historical forests in a rapidly urbanizing area

description: This data set contains all data used for analyzing the impacts of temporal changes in land use/cover on the remaining historical forests in Guiyang, China. It has two parts: (1) Data of land use/cover of built-up area from 1976 to 2018; (2) Spatial locations of urban historical forest patches.
DOI: 10.17632/jsms7sdpb2.1
title: Saturation correction of resistivity

description: Test data for resistivity saturation correction in response to revisions
DOI: 10.17632/rm56r2md7m.3
title: Dataset of UV-C Emitting Properties of Pr3+-activated Rare Earth Phosphates Driven by Structural Lattice Distortion Through Substitutional Doping Strategy

description: The data named as Figure3 are related to the X-ray diffraction (XRD) patterns acquired for Y1-xLaxPO4:Pr3+ upon varying the La concentration from 1-21 mol.%. The data named as Figure4 are associated with photoluminescence emission (PL) spectra for Pr3+-activated La (5 mol.%)-doped YPO4:Pr3+ (Pr3+ 3 mol.%) under the different excitation wavelength of 220, 223, 225, 228, and 230 nm. The data named as Figure5 are associated with photoluminescence emission (PL) spectra acquired for Pr3+-activated La (x mol.%)-doped YPO4:Pr3+ (Pr3+ 3 mol.%) as a function of La concentration varied from 0-25 mol.% (x = 0-0.25) under the excitation wavelength of 225 nm
DOI: 10.17632/xgcy9cbwp2.1
title: Operational strategies for managing private equity funds in emerging markets

description: Data set for several hypothesis testing for master's research on "Operational strategies for managing private equity funds in emerging markets". There are 3 different parts of the data set for each group of hypothesis: 1.1 "Active operational strategies show higher returns than passive investment strategies" 1.2 "Private equity funds with an active investment strategy in emerging markets show higher returns compared to similar funds in developed markets" 2.1 "Active venture investment strategy provides higher profitability indicators for private equity funds compared to passive strategy" 2.2 "Active venture investment strategies are more profitable in emerging markets compared to developed ones" 3.1 "The strategy of" distressed assets and secondary buyouts of companies" has a positive effect on the profitability of private equity funds compared to passive investment strategies» 3.2 "Strategies for" distressed assets and secondary buyouts of companies" are more profitable in emerging markets compared to developed ones» Every part has initial form of data and data set for regression analysis as well as for correlation analysis. Data set include values for private equity funds metrics: Return (IRR), Size of the fund, Experience of the fund, Region of the main investments and Active investment strategy usage (binary variable).
DOI: 10.17632/4rrggzv5d5.1
title: SC_atlas_P56

description: Reference atlas for adult mouse SC.
DOI: 10.17632/tydm4x2zj6.2
title: Drug Survival of Systemic and Biologic Monotherapy Treatments for Pityriasis Rubra Pilaris: A Retrospective Observational Study

description: Supplemental Table I. Demographic Data Supplemental Table II. Reason for treatment failure Supplemental Figure 1. Inclusion and Exclusion Criteria
DOI: 10.17632/jmx3b75vwc.1
title: my publications

description: My journal publications est. 2018
DOI: 10.17632/yj9zy3chwr.1
title: The impact of intellectual capital structure on financial performance of telecommunications companies in emerging markets

description: Dataset for analysis of the impact of intellectual capital structure on financial performance of telecommunications companies in emerging markets
DOI: 10.17632/hw6zwkc642.1
title: Impact of debt issuance news on the share price of Russian companies given the personal characteristics of their management

description: This dataset was created to conduct event study proving that debt issuence makes impact on share price of Russian listed companies. The dataset provides data with respect to companies included in blue chips index of Moscow Exchange for the period of 2010-2019. This dataset also provides information about CEOs of these companies for respective periods.
DOI: 10.17632/mbpf96y497.1
title: A Compilation of Investigational, Preclinical and Clinical Enzyme Based Therapeutics

description: A compiled list of Investigational, Preclinical and Clinical Enzyme Based Therapeutics, included within 4 Tables Table 1: Enzyme based therapeutics by class & challenges to clinical use Table 2: All FDA Approved Protein based therapeutics , 1965-2020 Table 3: FDA Approved Enzyme based therapeutics , 1965-2020 Table 4: Early Investigational Enzyme based therapeutics
DOI: 10.17632/wwk2t9ftdp.2
title: penicillium marneffei

description: Characteristic CD86 stain for organisms in cutaneous lesions of Talaromyces marneffei infection
DOI: 10.17632/z9xkyzp8p8.1
title: Critical contribution of 3’ non-seed base pairing to the in vivo function of the evolutionarily conserved let-7a microRNA

description: Base-pairing of the seed region (g2-g8) is essential for microRNA targeting, however, the in vivo functions of the 3’ non-seed region (g9-g22) are less well understood. Here we report the first systematic investigation of the in vivo roles of 3’ non-seed nucleotides in microRNA let-7a, whose entire g9-g22 region is conserved among bilaterians. We found that the 3’ non-seed sequence functionally distinguishes let-7a from its family paralogs. The complete pairing of g11-g16 is essential for let-7a to fully repress multiple key targets, including evolutionarily conserved lin-41, daf-12 and hbl-1. Nucleotides at g17-g22 are less critical but may compensate for mismatches in the g11-g16 region. Interestingly, the 3’ non-seed pairing of let-7a can be critically required even with sites that permit perfect seed pairing. These results provide evidence that the specific configurations of both seed and 3’ non-seed base-pairing can critically influence microRNA-mediated gene regulation in vivo.
DOI: 10.17632/p36hd8ywz5.1
title: SARS-CoV-2 genomic surveillance identifies naturally occurring truncation of ORF7a that limits immune suppression. Nemudryi et al.

description: Over 950,000 whole-genome sequences of SARS-CoV-2 have been determined for viruses isolated from around the world. These sequences have been critical for understanding the spread and evolution of SARS-CoV-2. Using global phylogenomics, we show that mutations frequently occur in the C-terminal end of ORF7a. We have isolated one of these mutant viruses from a patient sample and used viral challenge experiments to link this isolate (ORF7aΔ115) to a growth defect. ORF7a has been implicated in immune modulation. We show that the C-terminal truncation negates the anti-immune activities of the protein, which results in elevated type I interferon response to the viral infection. Collectively, this work indicates that ORF7a mutations occur frequently and that these changes affect viral mechanisms responsible for suppressing the immune response.
DOI: 10.17632/76r6j4n2y5.1
title: Metabolic changes during plant development of N.benthamiana and tabacum

description: LCMS analysis of methanol/water extract of N. benthamiana and N. tabacum leaves. GCMS analysis of methanol/water and chloroform leaf extract, labelled as polar and nonpolar, respectively. Data presents raw output from Agilent Profiler and AMDIS.
DOI: 10.17632/rvnk26krjs.1
title: Geological and geophysical data compilation for the western Wabigoon and southern Abitibi subprovinces of the Superior Province, Ontario, Canada

description: Geological layers representing geological observations (e.g., structural measurements, mineral occurrences) and interpretations (e.g., faults traces, map units) for and Archean greenstone belt near Dryden and Timmins, Ontario, Canada in the geological Superior Province. Newly interpreted layers such as lithology polygons (‘MapUnits’) and structural traces (‘Geolines’) are included as ESRI shapefiles. Two geophysical datasets are provided, including a database of new magnetic susceptibility measurements from 2018 and 2019 field seasons near Dryden, Ontario. Additionally, an ensemble of reprocessed aeromagnetic grids (40 m by 40 m cell size) from the Ontario Geological Survey’s (2011) geophysical survey datasets are included as projected geo .tiff and .grd files. The ensemble includes total magnetic intensity with cosine roll off filtering, first vertical derivative, second vertical derivative, tilt derivative, and dynamic range compression. Hill-shaded relief grids are also included, and their azimuth and angle of incidence are indicated in their filename.