cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.5756064
title: A new approach for modeling patient overall radiosensitivity and predicting multiple toxicity endpoints for breast cancer patients

description: <b>Introduction:</b> Evaluation of patient characteristics inducing toxicity in breast radiotherapy, using simultaneous modeling of multiple endpoints. <b>Methods and Materials:</b> In 269 early-stage breast cancer patients treated with whole-breast irradiation (WBI) after breast-conserving surgery, toxicity was scored, based on five dichotomized endpoints. Five logistic regression models were fitted, one for each endpoint and the effect sizes of all variables were estimated using maximum likelihood (MLE). The MLEs are improved with James–Stein estimates (JSEs). The method combines all the MLEs, obtained for the same variable but from different endpoints. Misclassification errors were computed using MLE- and JSE-based prediction models. For associations, <i>p-</i>values from the sum of squares of MLEs were compared with <i>p</i>-values from the Standardized Total Average Toxicity (STAT) Score. <b>Results:</b> With JSEs, 19 highest ranked variables were predictive of the five different endpoints. Important variables increasing radiation-induced toxicity were chemotherapy, age, SATB2 rs2881208 SNP and nodal irradiation. Treatment position (prone position) was most protective and ranked eighth. Overall, the misclassification errors were 45% and 34% for the MLE- and JSE-based models, respectively. <i>p-</i>Values from the sum of squares of MLEs and <i>p-</i>values from STAT score led to very similar conclusions, except for the variables nodal irradiation and treatment position, for which STAT <i>p</i>-values suggested an association with radiosensitivity, whereas <i>p</i>-values from the sum of squares indicated no association. Breast volume was ranked as the most significant variable in both strategies. <b>Discussion:</b> The James–Stein estimator was used for selecting variables that are predictive for multiple toxicity endpoints. With this estimator, 19 variables were predictive for all toxicities of which four were significantly associated with overall radiosensitivity. JSEs led to almost 25% reduction in the misclassification error rate compared to conventional MLEs. Finally, patient characteristics that are associated with radiosensitivity were identified without explicitly quantifying radiosensitivity.
DOI: 10.6084/m9.figshare.5756064.v1
title: A new approach for modeling patient overall radiosensitivity and predicting multiple toxicity endpoints for breast cancer patients

description: <b>Introduction:</b> Evaluation of patient characteristics inducing toxicity in breast radiotherapy, using simultaneous modeling of multiple endpoints. <b>Methods and Materials:</b> In 269 early-stage breast cancer patients treated with whole-breast irradiation (WBI) after breast-conserving surgery, toxicity was scored, based on five dichotomized endpoints. Five logistic regression models were fitted, one for each endpoint and the effect sizes of all variables were estimated using maximum likelihood (MLE). The MLEs are improved with James–Stein estimates (JSEs). The method combines all the MLEs, obtained for the same variable but from different endpoints. Misclassification errors were computed using MLE- and JSE-based prediction models. For associations, <i>p-</i>values from the sum of squares of MLEs were compared with <i>p</i>-values from the Standardized Total Average Toxicity (STAT) Score. <b>Results:</b> With JSEs, 19 highest ranked variables were predictive of the five different endpoints. Important variables increasing radiation-induced toxicity were chemotherapy, age, SATB2 rs2881208 SNP and nodal irradiation. Treatment position (prone position) was most protective and ranked eighth. Overall, the misclassification errors were 45% and 34% for the MLE- and JSE-based models, respectively. <i>p-</i>Values from the sum of squares of MLEs and <i>p-</i>values from STAT score led to very similar conclusions, except for the variables nodal irradiation and treatment position, for which STAT <i>p</i>-values suggested an association with radiosensitivity, whereas <i>p</i>-values from the sum of squares indicated no association. Breast volume was ranked as the most significant variable in both strategies. <b>Discussion:</b> The James–Stein estimator was used for selecting variables that are predictive for multiple toxicity endpoints. With this estimator, 19 variables were predictive for all toxicities of which four were significantly associated with overall radiosensitivity. JSEs led to almost 25% reduction in the misclassification error rate compared to conventional MLEs. Finally, patient characteristics that are associated with radiosensitivity were identified without explicitly quantifying radiosensitivity.
DOI: 10.6084/m9.figshare.5756055
title: Automated leak localization performance without detailed demand distribution data

description: Automatic leak localization has been suggested to reduce the time and personnel efforts needed to localize (small) leaks. Yet, the available methods require a detailed demand distribution model for successful calibration and good leak localization performance. The main aim of this work was to analyze whether such a detailed demand distribution is needed. Two demand distributions were used: a factorized distribution that distributes the inflow demand proportionally across the consumption nodes according to individual billing data, and a uniform distribution that equally distributes demand across all consumption nodes. The performance of the automatic leak localization method, using both demand distribution models, was compared. A new measure for leak localization performance that is based on the percentage of false positive nodes is proposed. It was possible to localize the leaks with both demand distribution models, although performance varied depending on the timing and duration of the measurement.
DOI: 10.6084/m9.figshare.5756055.v1
title: Automated leak localization performance without detailed demand distribution data

description: Automatic leak localization has been suggested to reduce the time and personnel efforts needed to localize (small) leaks. Yet, the available methods require a detailed demand distribution model for successful calibration and good leak localization performance. The main aim of this work was to analyze whether such a detailed demand distribution is needed. Two demand distributions were used: a factorized distribution that distributes the inflow demand proportionally across the consumption nodes according to individual billing data, and a uniform distribution that equally distributes demand across all consumption nodes. The performance of the automatic leak localization method, using both demand distribution models, was compared. A new measure for leak localization performance that is based on the percentage of false positive nodes is proposed. It was possible to localize the leaks with both demand distribution models, although performance varied depending on the timing and duration of the measurement.
DOI: 10.6084/m9.figshare.5756022
title: Test data for electricity-gas IES robust security region

description: 1) Test data for two electricity-gas integrated energy systems are included.2) Refer to my paper "Convex Hull Based Robust Security Region for Electricity-Gas Integrated Energy Systems" if published online.
DOI: 10.6084/m9.figshare.5756022.v1
title: Test data for electricity-gas IES robust security region

description: 1) Test data for two electricity-gas integrated energy systems are included.2) Refer to my paper "Convex Hull Based Robust Security Region for Electricity-Gas Integrated Energy Systems" if published online.
DOI: 10.6084/m9.figshare.5756001
title: Behavioral data

description: During Task-counting, participants counted the number of perceived alternations in rotation direction and reported the total count after each run (of 10 minutes). The data is cointained in 'behav_counting_upload.mat'.<br>During Task-pressing, participants pressed whenever they perceived an alternations in rotation direction and the number of button presses was summed. The data is cointained in 'behav_pressing_upload.mat'<br><br>Each matrix is of size 28x3, where 28 is the number of subjects and 3 the number of pharma conditions (1 = placebo, 2 = atomoxetine, 3 = donepezil). The data is averaged across 2 runs per session. See Materials and Methods of the paper for more details.
DOI: 10.6084/m9.figshare.5756001.v1
title: Behavioral data (Task-counting)

description: During Task-counting, participants counted the number of perceived alternations in rotation direction and reported the total count after each run (of 10 minutes).<br>The matrix is of size 28x3, where 28 is the number of subjects and 3 the number of pharma conditions (1 = placebo, 2 = atomoxetine, 3 = donepezil). The data is averaged across 2 runs per session.
DOI: 10.6084/m9.figshare.5755983
title: Docking assisted design of novel 4-adamantanyl-2-thiazolylimino-5-arylidene-4-thiazolidinones as potent NSAIDs<sup>$</sup>

description: Docking analysis was used to predict the effectiveness of adamantanyl insertion in improving cycloxygenase/lipoxygenase (COX/LOX) inhibitory action of previously tested 2-thiazolylimino-5-arylidene-4-thiazolidinones. The crystal structure data of human 5-LOX (3O8Y), ovine COX-1 (1EQH) and mouse COX-2 (3ln1) were used for docking analysis. All docking calculations were carried out using AutoDock 4.2 software. Following prediction results, 11 adamantanyl derivatives were synthesized and evaluated for biological action. Prediction evaluations correlated well with experimental biological results. Comparison of the novel adamantanyl derivatives with the 2-thiazolylimino-5-arylidene-4-thiazolidinones previously tested showed that insertion of the adamantanyl group led to the production of more potent COX-1 inhibitors, as well as LOX inhibitors (increased activity from 200% to 560%). Five compounds out of the 11 exhibited better activity than naproxen; while nine out of 11 showed better activity than NDGA and seven compounds possessed better anti-inflammatory activity than indomethacin.
DOI: 10.6084/m9.figshare.5755983.v1
title: Docking assisted design of novel 4-adamantanyl-2-thiazolylimino-5-arylidene-4-thiazolidinones as potent NSAIDs<sup>$</sup>

description: Docking analysis was used to predict the effectiveness of adamantanyl insertion in improving cycloxygenase/lipoxygenase (COX/LOX) inhibitory action of previously tested 2-thiazolylimino-5-arylidene-4-thiazolidinones. The crystal structure data of human 5-LOX (3O8Y), ovine COX-1 (1EQH) and mouse COX-2 (3ln1) were used for docking analysis. All docking calculations were carried out using AutoDock 4.2 software. Following prediction results, 11 adamantanyl derivatives were synthesized and evaluated for biological action. Prediction evaluations correlated well with experimental biological results. Comparison of the novel adamantanyl derivatives with the 2-thiazolylimino-5-arylidene-4-thiazolidinones previously tested showed that insertion of the adamantanyl group led to the production of more potent COX-1 inhibitors, as well as LOX inhibitors (increased activity from 200% to 560%). Five compounds out of the 11 exhibited better activity than naproxen; while nine out of 11 showed better activity than NDGA and seven compounds possessed better anti-inflammatory activity than indomethacin.
DOI: 10.6084/m9.figshare.5755938
title: SNPs in corkwing wrasses (n=65) from Northern Europe

description: 2.1 million SNPs in corkwing wrasse (Symphodus melops) in Northern Europe.
DOI: 10.6084/m9.figshare.5755938.v1
title: SNPs in corkwing wrasses (n=65) from Northern Europe

description: 2.1 million SNPs in corkwing wrasse (Symphodus melops) in Northern Europe.
DOI: 10.6084/m9.figshare.5755935
title: Supplementary Material for: Severe Inflammatory Ophthalmopathy in a Euthyroid Patient during Nivolumab Treatment

description: <b><i>Introduction:</i></b> Nivolumab is a promising treatment in patients with advanced malignancies. Among immune-related adverse events, autoimmune thyroid disorders are frequently reported. <b><i>Patient:</i></b> A 61-year-old male patient had no history of familial or personal thyroid disease. In 2012, this patient, a heavy smoker, presented with non-small-cell lung cancer that was treated with radiotherapy and chemotherapy. In 2015, the cancer progressed with cervical compressive symptoms, and the patient was treated with nivolumab. <b><i>Results:</i></b> After 3 infusions, bilateral eyelid ptosis and bilateral conjunctival redness with chemosis were observed. Ophthalmologic examination revealed severe proptosis with complete ophthalmoplegia but with normal vision, color test, and optic disk. Thyroid function tests were normal (TSH = 0.65 mU/L, free T<sub>4</sub> = 15.4 pmol/L) without anti-thyroperoxidase or anti-TSH receptor antibodies. CT scan of the orbits confirmed marked bilateral proptosis with expansion of the orbital adipose tissue without significant thickening of extraocular muscles. T2-weighted MRI showed inflammation of orbital adipose tissue. Nivolumab treatment was withdrawn, and the patient received weekly intravenous high-dose methylprednisolone (1 g for 2 weeks, 500 mg for 4 weeks, and 250 mg for 5 weeks). After the first 3 cycles, significant improvement of left chemosis was observed whereas bilateral ptosis and ophthalmoplegia were unchanged. The patient was euthyroid without thyroid autoimmunity 1 week prior to his death due to massive hemoptysis. <b><i>Conclusion:</i></b> We report severe inflammatory ophthalmopathy in a euthyroid patient with non-small-cell lung cancer during nivolumab therapy. The occurrence of such ophthalmic adverse events is likely to increase during nivolumab therapy in patients with advanced malignancies.
DOI: 10.6084/m9.figshare.5755929
title: Sequence variants in corkwing wrasses (n=65) from Northern Europe

description: 2.8 million sequence variants in corkwing wrasse (Symphodus melops) in Northern Europe.
DOI: 10.6084/m9.figshare.5755929.v1
title: Sequence variants in corkwing wrasses (n=65) from Northern Europe

description: 2.8 million sequence variants in corkwing wrasse (Symphodus melops) in Northern Europe.
DOI: 10.6084/m9.figshare.5755926
title: AKESoloMatching.Vers.2.3.pdf

description: Statistic
DOI: 10.6084/m9.figshare.5755926.v1
title: AKESoloMatching.Vers.2.3.pdf

description: Statistic
DOI: 10.6084/m9.figshare.5755923
title: Multi-stage pyrite genesis and epigenetic selenium enrichment of Greenburn coals (East Ayrshire)

description: LA–ICP–MS maps for Fe, Se, Ag, As, Cu, Hg, Pb and Te for Greenburn coal samples from seams 9300 Lime and 6900 Burnfoot Bridge.
DOI: 10.6084/m9.figshare.5755863
title: Classification of Diffuse large B cell lymphoma subtypes using MALDI IMS

description: MALDI IMS spectra from 2 samples each of DLBCL subtypes: GC and ABC (non-GC).
DOI: 10.6084/m9.figshare.5755863.v1
title: Classification of Diffuse large B cell lymphoma subtypes using MALDI IMS

description: MALDI IMS spectra from 2 samples each of DLBCL subtypes: GC and ABC (non-GC).
DOI: 10.6084/m9.figshare.5755851.v2
title: Bleeding pattern difference between levonorgestrel intrauterine system and copper intrauterine devices inserted immediately post-abortion: a multicenter, prospective, observational cohort study in Chinese women

description: <b>Background:</b> To describe the bleeding pattern (primary outcome), side effects, treatment satisfaction and 6 month continuity rates associated with the 52 mg levonorgestrel intrauterine system (LNG-IUS) and the copper intrauterine device (Cu-IUD) inserted immediately after abortion. <b>Methods:</b> This multicenter, prospective, observational cohort study enrolled healthy women (aged ≥18 years) inserted with LNG-IUS or Cu-IUD immediately after first-trimester surgical abortion and followed up to 6 months. Bleeding pattern was obtained through daily patient bleeding diaries. <b>Results:</b> From 2013 to 2014, we enrolled 512 women (LNG-IUS = 312 [median age: 32.0 years] and Cu-IUD = 200 [median age: 30.0 years]) from nine Chinese centers. LNG-IUS resulted in a significantly lower number of bleeding/spotting days in the second 90 day reference period compared with Cu-IUD (median 14.5 vs. 18.0 days, <i>p</i> p p = .0047). Both treatments had a high satisfaction rate among women at both the follow-up visits, and the majority of them continued with the treatment. The rates of adverse events (e.g. oligomenorrhea, amenorrhea) in the LNG-IUS and Cu-IUD groups were 77.2% and 44.5% (<i>p</i> <b>Conclusion:</b> LNG-IUS post-abortion shows better bleeding patterns, and reduced dysmenorrhea and bleeding amount, but with a similar safety profile compared with Cu-IUD. <b>ClinicalTrials.gov identifier:</b> NCT01958684
DOI: 10.6084/m9.figshare.5755851.v1
title: Bleeding pattern difference between levonorgestrel-intrauterine system and copper-intrauterine devices inserted immediately post-abortion: a multicenter, prospective, observational cohort study in Chinese women

description: <b>Background:</b> To describe the bleeding pattern (primary outcome), side effects, treatment satisfaction, and 6-month continuity rates of 52 mg levonorgestrel-intrauterine system (LNG-IUS) and copper intrauterine device (Cu-IUD) inserted immediately after abortion. <b>Methods:</b> This multicenter, prospective, observational cohort study enrolled healthy women (aged ≥18 years) inserted with LNG-IUS or Cu-IUD immediately after first-trimester surgical abortion and were followed up to 6 months. Bleeding pattern was obtained through daily patient bleeding diaries. <b>Results:</b> From 2013–2014, we enrolled 512 women [LNG-IUS = 312 (median age: 32.0 years) and Cu-IUD = 200 (median age: 30.0 years)] from 9 Chinese centers. LNG-IUS resulted in a significantly lower number of bleeding/spotting days in the second 90-day reference period compared with Cu-IUD (median 14.5 vs. 18.0 days, <i>P</i>&lt;0.0001). Amenorrhea rate (no bleeding/spotting day in the second 90-day reference period) and no menstrual bleeding rate (absence of bleeding days in the second 90-day reference period) were significantly higher in LNG-IUS compared to Cu-IUD (13.9% vs. 0% and 39.5% vs. 0%; <i>P</i>&lt;0.001 for all). No dysmenorrhea was higher at the last follow-up in LNG-IUS users than Cu-IUD users (81.2% vs. 76%; <i>P</i> = 0.0047). Both treatments had a high satisfaction rate among women at both the follow-up visits, and majority of them continued with the treatment. The rates of adverse events (e.g. oligomenorrhea, amenorrhea) in the LNG-IUS and Cu-IUD groups were 77.2% and 44.5% (<i>P</i>&lt;0.0001), respectively. <b>Conclusion:</b> LNG-IUS post-abortion shows better bleeding patterns, and reduced dysmenorrhea and bleeding amount, but with similar safety profile compared with Cu-IUD. ClinicalTrials.gov identifier: NCT01958684
DOI: 10.6084/m9.figshare.5755815
title: Additional file 9: of The gonadal transcriptome of the unisexual Amazon molly Poecilia formosa in comparison to its sexual ancestors, Poecilia mexicana and Poecilia latipinna

description: Blast results for the sequence comparisons between the Poecilia mexicana transcriptome and the Uniprot/Swiss-Prot database. (TXT 8636Â kb)
DOI: 10.6084/m9.figshare.5755815.v1
title: Additional file 9: of The gonadal transcriptome of the unisexual Amazon molly Poecilia formosa in comparison to its sexual ancestors, Poecilia mexicana and Poecilia latipinna

description: Blast results for the sequence comparisons between the Poecilia mexicana transcriptome and the Uniprot/Swiss-Prot database. (TXT 8636Â kb)
DOI: 10.6084/m9.figshare.5755812
title: Additional file 8: of The gonadal transcriptome of the unisexual Amazon molly Poecilia formosa in comparison to its sexual ancestors, Poecilia mexicana and Poecilia latipinna

description: Blast results for the sequence comparisons between the Poecilia latipinna transcriptome and the Uniprot/Swiss-Prot database. (TXT 7176Â kb)
DOI: 10.6084/m9.figshare.5755812.v1
title: Additional file 8: of The gonadal transcriptome of the unisexual Amazon molly Poecilia formosa in comparison to its sexual ancestors, Poecilia mexicana and Poecilia latipinna

description: Blast results for the sequence comparisons between the Poecilia latipinna transcriptome and the Uniprot/Swiss-Prot database. (TXT 7176Â kb)
DOI: 10.6084/m9.figshare.5755806
title: Additional file 7: of The gonadal transcriptome of the unisexual Amazon molly Poecilia formosa in comparison to its sexual ancestors, Poecilia mexicana and Poecilia latipinna

description: Blast results for the sequence comparisons between the Poecilia formosa transcriptome and the Uniprot/Swiss-Prot database. (TXT 7495Â kb)
DOI: 10.6084/m9.figshare.5755806.v1
title: Additional file 7: of The gonadal transcriptome of the unisexual Amazon molly Poecilia formosa in comparison to its sexual ancestors, Poecilia mexicana and Poecilia latipinna

description: Blast results for the sequence comparisons between the Poecilia formosa transcriptome and the Uniprot/Swiss-Prot database. (TXT 7495Â kb)
DOI: 10.6084/m9.figshare.5755803
title: Additional file 9: Table S5. of Global accumulation of circRNAs during aging in Caenorhabditis elegans

description: Gene Ontology analysis for circRNA host genes. (XLSX 47 kb)
DOI: 10.6084/m9.figshare.5755803.v1
title: Additional file 9: Table S5. of Global accumulation of circRNAs during aging in Caenorhabditis elegans

description: Gene Ontology analysis for circRNA host genes. (XLSX 47 kb)
DOI: 10.6084/m9.figshare.5755782
title: Additional file 7: Table S6. of Global accumulation of circRNAs during aging in Caenorhabditis elegans

description: Host-independent circRNA expression analysis using CircTest. (XLSX 139 kb)
DOI: 10.6084/m9.figshare.5755782.v1
title: Additional file 7: Table S6. of Global accumulation of circRNAs during aging in Caenorhabditis elegans

description: Host-independent circRNA expression analysis using CircTest. (XLSX 139 kb)
DOI: 10.6084/m9.figshare.5755770
title: Additional file 6: Table S4. of Global accumulation of circRNAs during aging in Caenorhabditis elegans

description: Linear RNA differential expression analysis. (XLSX 2355 kb)
DOI: 10.6084/m9.figshare.5755770.v1
title: Additional file 6: Table S4. of Global accumulation of circRNAs during aging in Caenorhabditis elegans

description: Linear RNA differential expression analysis. (XLSX 2355 kb)
DOI: 10.6084/m9.figshare.5755752
title: Additional file 5: Table S3. of Global accumulation of circRNAs during aging in Caenorhabditis elegans

description: circRNA expression data. (XLSX 385 kb)
DOI: 10.6084/m9.figshare.5755752.v1
title: Additional file 5: Table S3. of Global accumulation of circRNAs during aging in Caenorhabditis elegans

description: circRNA expression data. (XLSX 385 kb)
DOI: 10.6084/m9.figshare.5755740
title: Additional file 4: Table S2. of Global accumulation of circRNAs during aging in Caenorhabditis elegans

description: Oligonucleotides used for experimental validation. (XLSX 75 kb)
DOI: 10.6084/m9.figshare.5755740.v1
title: Additional file 4: Table S2. of Global accumulation of circRNAs during aging in Caenorhabditis elegans

description: Oligonucleotides used for experimental validation. (XLSX 75 kb)
DOI: 10.6084/m9.figshare.5755710
title: Additional file 7: of A multi-omics approach reveals function of Secretory Carrier-Associated Membrane Proteins in wood formation of​ ​​Populus​​ ​trees

description: Py-GC/MS analysis of wild type and PttSCAMP3 RNAi plants. (XLSX 14 kb)
DOI: 10.6084/m9.figshare.5755710.v1
title: Additional file 7: of A multi-omics approach reveals function of Secretory Carrier-Associated Membrane Proteins in wood formation of​ ​​Populus​​ ​trees

description: Py-GC/MS analysis of wild type and PttSCAMP3 RNAi plants. (XLSX 14 kb)
DOI: 10.6084/m9.figshare.5755704
title: Additional file 2: Table S1. of Global accumulation of circRNAs during aging in Caenorhabditis elegans

description: RNA-seq read statistics. (XLSX 11 kb)
DOI: 10.6084/m9.figshare.5755704.v1
title: Additional file 2: Table S1. of Global accumulation of circRNAs during aging in Caenorhabditis elegans

description: RNA-seq read statistics. (XLSX 11 kb)