cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.23544414.v1
title: Genome sequencing reveals molecular subgroups in oral epithelial dysplasia

description: Abstract This study aimed to analyze the molecular characteristics of oral epithelial dysplasia (OED), highlighting the pathways and variants of genes that are frequently mutated in oral squamous cell carcinoma (OSCC) and other cancers. Ten archival OED cases were retrieved for retrospective clinicopathological analysis and exome sequencing. Comparative genomic analysis was performed between high-grade dysplasia (HGD) and low-grade dysplasia (LGD), focusing on 57 well-known cancer genes, of which 10 were previously described as the most mutated in OSCC. HGD cases had significantly more variants; however, a similar mutational landscape to OSCC was observed in both groups. CASP8+FAT1/HRAS, TP53, and miscellaneous molecular signatures were also present. FAT1 is the gene that is most affected by pathogenic variants. Hierarchical divisive clustering showed division between the two groups: “HGD-like cluster” with 4HGD and 2LGD and “LGD-like cluster” with 4 LGD. MLL4 pathogenic variants were exclusively in the “LGD-like cluster”. TP53 was affected in one case of HGD; however, its pathway was usually altered. We describe new insights into the genetic basis of epithelial malignant transformation by genomic analysis, highlighting those associated with FAT1 and TP53. Some LGDs presented a similar mutational landscape to HGD after cluster analysis. Perhaps molecular alterations have not yet been reflected in histomorphology. The relative risk of malignant transformation in this molecular subgroup should be addressed in future studies.
DOI: 10.6084/m9.figshare.23544416
title: Private investment in Latin America

description: ABSTRACT This paper studies investment in Latin America and explores the relationship of investment with growth, exchange rates and the terms of trade. It addresses the theoretical issue of the relationship between the real exchange rate and the real price of capital with a model of a small open economy with four assets. It discusses the dynamics of both the real price of capital and the real exchange rate in response to different shock, including a change in monetary policy, an increase in external interest rates and a deterioration of the terms of trade. In the model (with a nominal exchange rate rule fixed by the central bank) a deterioration of the terms of trade leads to an immediate decline of the real price of capital, followed by a depreciating real exchange rate while the real price of capital slowly recovers. The paper explores the determinants of investment in Latin America. The regressions use quadrennial panel data for the period 1970-1985 in Argentina, Brazil, Chile, Colombia, Mexico and Venezuela. Together, these six countries account for 86 percent of the total GDP of the region. The decline in private investment shares in Latin America during the 1980s seems to result from the deterioration in the terms of trade, from the decline in growth (resulting from adjustment programs designed to reduce current account deficits), from a reduction in complementary public investment, from increased macroeconomic instability, and from a large stock of foreign debt. The real exchange rate and the real rate of depreciation have no significant role in the determination of private investment.
DOI: 10.6084/m9.figshare.23544416.v1
title: Private investment in Latin America

description: ABSTRACT This paper studies investment in Latin America and explores the relationship of investment with growth, exchange rates and the terms of trade. It addresses the theoretical issue of the relationship between the real exchange rate and the real price of capital with a model of a small open economy with four assets. It discusses the dynamics of both the real price of capital and the real exchange rate in response to different shock, including a change in monetary policy, an increase in external interest rates and a deterioration of the terms of trade. In the model (with a nominal exchange rate rule fixed by the central bank) a deterioration of the terms of trade leads to an immediate decline of the real price of capital, followed by a depreciating real exchange rate while the real price of capital slowly recovers. The paper explores the determinants of investment in Latin America. The regressions use quadrennial panel data for the period 1970-1985 in Argentina, Brazil, Chile, Colombia, Mexico and Venezuela. Together, these six countries account for 86 percent of the total GDP of the region. The decline in private investment shares in Latin America during the 1980s seems to result from the deterioration in the terms of trade, from the decline in growth (resulting from adjustment programs designed to reduce current account deficits), from a reduction in complementary public investment, from increased macroeconomic instability, and from a large stock of foreign debt. The real exchange rate and the real rate of depreciation have no significant role in the determination of private investment.
DOI: 10.57841/casdc.0001185
title: 迁地保护植物数据集
DOI: 10.6084/m9.figshare.22776989.v1
title: Low power flexible monolayer MoS2 integrated circuits

description: Low power flexible monolayer MoS2 integrated circuits
DOI: 10.6084/m9.figshare.22776989
title: Low power flexible monolayer MoS2 integrated circuits

description: Low power flexible monolayer MoS2 integrated circuits
DOI: 10.6084/m9.figshare.22816394.v1
title: Collective photothermal bending of flexible organic crystals modified with MXene-polymer multilayers as optical waveguide arrays

description: Combined source data used to plot the figures.
DOI: 10.6084/m9.figshare.22816394
title: Collective photothermal bending of flexible organic crystals modified with MXene-polymer multilayers as optical waveguide arrays

description: Combined source data used to plot the figures.
DOI: 10.6084/m9.figshare.23544420
title: Prognostic Assessment of Fractional Flow Reserve in Different Strata in Patients with Coronary Artery Disease

description: Abstract Background There are limited real-world data on the clinical course of untreated coronary lesions according to their functional severity. Objective To evaluate the 5-year clinical outcomes of patients with revascularized lesions with fractional flow reserve (FFR) ≤ 0.8 and patients with non-revascularized lesions with FFR &gt; 0.8. Methods The FFR assessment was performed in 218 patients followed for up to 5 years. Participants were classified based on FFR into ischemia group (≤ 0.8, intervention group, n = 55), low-normal FFR group (&gt; 0.8-0.9, n = 91), and high-normal FFR group (&gt; 0.9, n = 72). The primary endpoint was major adverse cardiac events (MACEs), a composite of death, myocardial infarction, and need for repeat revascularization. The significance level was set at 0.05; therefore, results with a p-value &lt; 0.05 were considered statistically significant. Results Most patients were male (62.8%) with a mean age of 64.1 years. Diabetes was present in 27%. On coronary angiography, the severity of stenosis was 62% in the ischemia group, 56.4% in the low-normal FFR group, and 54.3% in the high-normal FFR group (p&lt;0.05). Mean follow-up was 3.5 years. The incidence of MACEs was 25.5%, 13.2%, and 11.1%, respectively (p=0.037). MACE incidence did not differ significantly between the low-normal and high-normal FFR groups. Conclusion Patients with FFR indicative of ischemia had poorer outcomes than those in non-ischemia groups. There was no difference in the incidence of events between the low-normal and high-normal FFR groups. Long-term studies with a large sample size are needed to better assess cardiovascular outcomes in patients with moderate coronary stenosis with FFR values between 0.8 and 1.0.
DOI: 10.6084/m9.figshare.23544420.v1
title: Prognostic Assessment of Fractional Flow Reserve in Different Strata in Patients with Coronary Artery Disease

description: Abstract Background There are limited real-world data on the clinical course of untreated coronary lesions according to their functional severity. Objective To evaluate the 5-year clinical outcomes of patients with revascularized lesions with fractional flow reserve (FFR) ≤ 0.8 and patients with non-revascularized lesions with FFR &gt; 0.8. Methods The FFR assessment was performed in 218 patients followed for up to 5 years. Participants were classified based on FFR into ischemia group (≤ 0.8, intervention group, n = 55), low-normal FFR group (&gt; 0.8-0.9, n = 91), and high-normal FFR group (&gt; 0.9, n = 72). The primary endpoint was major adverse cardiac events (MACEs), a composite of death, myocardial infarction, and need for repeat revascularization. The significance level was set at 0.05; therefore, results with a p-value &lt; 0.05 were considered statistically significant. Results Most patients were male (62.8%) with a mean age of 64.1 years. Diabetes was present in 27%. On coronary angiography, the severity of stenosis was 62% in the ischemia group, 56.4% in the low-normal FFR group, and 54.3% in the high-normal FFR group (p&lt;0.05). Mean follow-up was 3.5 years. The incidence of MACEs was 25.5%, 13.2%, and 11.1%, respectively (p=0.037). MACE incidence did not differ significantly between the low-normal and high-normal FFR groups. Conclusion Patients with FFR indicative of ischemia had poorer outcomes than those in non-ischemia groups. There was no difference in the incidence of events between the low-normal and high-normal FFR groups. Long-term studies with a large sample size are needed to better assess cardiovascular outcomes in patients with moderate coronary stenosis with FFR values between 0.8 and 1.0.
DOI: 10.6084/m9.figshare.23544422.v1
title: Spermatic cord torsion: a retrospective analysis

description: ABSTRACT Objective To evaluate the time interval and possible delay in transportation to referral units for the treatment of testicular torsion. Methods We retrospectively analyzed all cases of spermatic cord torsion surgically treated at a university hospital between January 2018 to December 2021. We evaluated the time intervals, including pain onset until the first presentation (D1), interhospital transference time (D2), pain onset until urological evaluation in a tertiary service (D3), urological evaluation until surgery (D4), and time from pain onset to surgical treatment (D5). We analyzed demographic and surgical data, orchiectomy rates, and time intervals (D1–D5). Torsions presented to the first medical presentation within 6h were considered early for testicular preservation. Results Of the 116 medical records evaluated, 87 had complete data for the time interval analysis (D1 to D5) and were considered the total sample. Thirty-three had D1 ≤6h, 53 had D1 ≤24h (includes patients in the D1 ≤6h subgroup), and 34 had D1 &gt;24h. The median time intervals of the total samples and subgroups D1 ≤6h, D1 ≤24h, and D1 &gt;24h were D1 = 16h 42min, 2h 43min, 4h 14min and 72h, D2 = 4h 41min, 3h 39min, 3h 44min and 9h 59min; D3 = 24h, 6h 40min, 7h and 96h; D4 = 2h 20min, 1h 43min, 1h 52min and 3h 44min; D5 = 24h 42min, 8h 03min, 9h 26min and 99h 10min, respectively. Orchiectomy rates of the total sample, subgroups D1 ≤6h, D1 ≤24h, and D1 &gt;24h were 56.32%, 24.24% (p&lt;0.01), 32.08% (p&lt;0.01), and 91.18% (p&lt;0.01), respectively. Conclusion Late arrival at the emergency department or a long interhospital transference time determined a large number of patients who underwent orchiectomy. Thus, public health measures and preventive strategies can be developed based on the data from this study aiming to reduce this avoidable outcome.
DOI: 10.6084/m9.figshare.23544422
title: Spermatic cord torsion: a retrospective analysis

description: ABSTRACT Objective To evaluate the time interval and possible delay in transportation to referral units for the treatment of testicular torsion. Methods We retrospectively analyzed all cases of spermatic cord torsion surgically treated at a university hospital between January 2018 to December 2021. We evaluated the time intervals, including pain onset until the first presentation (D1), interhospital transference time (D2), pain onset until urological evaluation in a tertiary service (D3), urological evaluation until surgery (D4), and time from pain onset to surgical treatment (D5). We analyzed demographic and surgical data, orchiectomy rates, and time intervals (D1–D5). Torsions presented to the first medical presentation within 6h were considered early for testicular preservation. Results Of the 116 medical records evaluated, 87 had complete data for the time interval analysis (D1 to D5) and were considered the total sample. Thirty-three had D1 ≤6h, 53 had D1 ≤24h (includes patients in the D1 ≤6h subgroup), and 34 had D1 &gt;24h. The median time intervals of the total samples and subgroups D1 ≤6h, D1 ≤24h, and D1 &gt;24h were D1 = 16h 42min, 2h 43min, 4h 14min and 72h, D2 = 4h 41min, 3h 39min, 3h 44min and 9h 59min; D3 = 24h, 6h 40min, 7h and 96h; D4 = 2h 20min, 1h 43min, 1h 52min and 3h 44min; D5 = 24h 42min, 8h 03min, 9h 26min and 99h 10min, respectively. Orchiectomy rates of the total sample, subgroups D1 ≤6h, D1 ≤24h, and D1 &gt;24h were 56.32%, 24.24% (p&lt;0.01), 32.08% (p&lt;0.01), and 91.18% (p&lt;0.01), respectively. Conclusion Late arrival at the emergency department or a long interhospital transference time determined a large number of patients who underwent orchiectomy. Thus, public health measures and preventive strategies can be developed based on the data from this study aiming to reduce this avoidable outcome.
DOI: 10.6084/m9.figshare.23544425
title: The modernization and deconcentrating of land in Mato Grosso agriculture: 1970/85

description: ABSTRACT Aiming the study of the evolution of the characteristics of the agricultural production in Mato Grosso and Mato Grosso do Sul, a dynamic analysis was made by using the main components method, with 26 variables, related to land tenure and use, technology, capital, employment and labor relations. Data obtained from agricultural census of 1970, 1975, 1980 and 1985, for 13 microregions of both States. All microregions presented modernization besides a reduction on land concentration and familiar labor force participation.
DOI: 10.6084/m9.figshare.23544425.v1
title: The modernization and deconcentrating of land in Mato Grosso agriculture: 1970/85

description: ABSTRACT Aiming the study of the evolution of the characteristics of the agricultural production in Mato Grosso and Mato Grosso do Sul, a dynamic analysis was made by using the main components method, with 26 variables, related to land tenure and use, technology, capital, employment and labor relations. Data obtained from agricultural census of 1970, 1975, 1980 and 1985, for 13 microregions of both States. All microregions presented modernization besides a reduction on land concentration and familiar labor force participation.
DOI: 10.6084/m9.figshare.23544426
title: The Human Host Defense Peptide LL-37 Overexpressed in Lung Cell Lines by Methanolic Extract of Valeriana officinalis

description: Abstract The present study investigated the effects of valerian methanolic extract and valerenic acid on the expression of LL-37 gene and protein in A549 and MRC5 line cells. After preparing Valerian seeds, sowing them in March 2020, and harvesting the rhizome in October 2020, the extract was prepared from the valerian rhizome by maceration method. Valerian acid content was determined using high performance liquid chromatography (HPLC). Two cell lines (A549 and MRC-5) were used to study the effects of valerian extract, and the MTT test was used to evaluate cell viability. The expression of LL-37 mRNA and protein was assessed by Real-Time PCR and western blot, respectively. In vivo safety assessments and histopathological analysis were also conducted. Data was analyzed by Graphpad Prism 8 software. Valerian methanolic extract and valerenic acid upregulated the LL-37 mRNA and protein expression in both treated cell lines. Valerenic acid showed a greater effect on upregulating LL-37 expression than valerian methanolic extract. A549 cells were more sensitive to valerian methanolic extract compared to MRC5 cells, and its cell viability was reduced. Furthermore, liver and kidney-related safety assessments showed that valerian methanolic extract had no toxic effects. In general, it was concluded that the methanolic extract of valerian as well as the resulting valerenic acid as the most important component of the extract has the ability to upregulate LL-37expression. Therefore, methanolic extract of valerian and valerenic acid can be considered for improving the immune system.
DOI: 10.6084/m9.figshare.23544426.v1
title: The Human Host Defense Peptide LL-37 Overexpressed in Lung Cell Lines by Methanolic Extract of Valeriana officinalis

description: Abstract The present study investigated the effects of valerian methanolic extract and valerenic acid on the expression of LL-37 gene and protein in A549 and MRC5 line cells. After preparing Valerian seeds, sowing them in March 2020, and harvesting the rhizome in October 2020, the extract was prepared from the valerian rhizome by maceration method. Valerian acid content was determined using high performance liquid chromatography (HPLC). Two cell lines (A549 and MRC-5) were used to study the effects of valerian extract, and the MTT test was used to evaluate cell viability. The expression of LL-37 mRNA and protein was assessed by Real-Time PCR and western blot, respectively. In vivo safety assessments and histopathological analysis were also conducted. Data was analyzed by Graphpad Prism 8 software. Valerian methanolic extract and valerenic acid upregulated the LL-37 mRNA and protein expression in both treated cell lines. Valerenic acid showed a greater effect on upregulating LL-37 expression than valerian methanolic extract. A549 cells were more sensitive to valerian methanolic extract compared to MRC5 cells, and its cell viability was reduced. Furthermore, liver and kidney-related safety assessments showed that valerian methanolic extract had no toxic effects. In general, it was concluded that the methanolic extract of valerian as well as the resulting valerenic acid as the most important component of the extract has the ability to upregulate LL-37expression. Therefore, methanolic extract of valerian and valerenic acid can be considered for improving the immune system.
DOI: 10.6084/m9.figshare.23544429
title: Scope of actions of community health workers in the COVID-19 pandemic: literature review

description: Abstract The objective of this article was to systematize scientific evidence on the work of community health workers during the pandemic period between 2020 and 2022 in countries in Africa, Asia, Europe and North America. The methodology used was literature review and evidence synthesis in the PubMed and Web of Science databases referring to international scientific productions on the community health workers’ actions. A total of 23 studies were selected for analysis in the categories: characterization of studies; scope of routine actions; and changes in the work process during the pandemic. The scope of the program of these professionals was presented in different ways in the countries studied. Even with interruptions or adaptations, some routine actions were maintained. However, its attributions suffered considerable changes due to the need for social distancing, especially the use of technologies. Strong evidence of its relevance was identified in countries that had or did not have the community health workers program previously. Thus, in view of the comprehensive scope of action, the community health workers should not constitute a temporary solution and not integrated with the formal health organization, but as a fundamental part of a health system to achieve the improvement of the population quality of life.
DOI: 10.6084/m9.figshare.23544429.v1
title: Scope of actions of community health workers in the COVID-19 pandemic: literature review

description: Abstract The objective of this article was to systematize scientific evidence on the work of community health workers during the pandemic period between 2020 and 2022 in countries in Africa, Asia, Europe and North America. The methodology used was literature review and evidence synthesis in the PubMed and Web of Science databases referring to international scientific productions on the community health workers’ actions. A total of 23 studies were selected for analysis in the categories: characterization of studies; scope of routine actions; and changes in the work process during the pandemic. The scope of the program of these professionals was presented in different ways in the countries studied. Even with interruptions or adaptations, some routine actions were maintained. However, its attributions suffered considerable changes due to the need for social distancing, especially the use of technologies. Strong evidence of its relevance was identified in countries that had or did not have the community health workers program previously. Thus, in view of the comprehensive scope of action, the community health workers should not constitute a temporary solution and not integrated with the formal health organization, but as a fundamental part of a health system to achieve the improvement of the population quality of life.
DOI: 10.6084/m9.figshare.23544428.v1
title: Graphical interpretation of adjustment program costs

description: ABSTRACT This work is based on a Bresser-Pereira’s paper, in which he proposes to represent the liquid costs of an economic adjustment applied upon a country. For that study he used a graphic tool. Generally speaking, we may say that there are two situations: the first one occurs when the country ‘s government decides to apply the adjustments and reforms as soon as distortions appear. The second one happens when the government, in spite of the evidences, muddling through reforms, waits for a society consensus. To illustrate this two different cases, Mexico and Argentina were chosen. Although the graphic tried to show the transitional costs of adjustment, it is possible to deduce other interesting things - basis of this work.
DOI: 10.6084/m9.figshare.23544428
title: Graphical interpretation of adjustment program costs

description: ABSTRACT This work is based on a Bresser-Pereira’s paper, in which he proposes to represent the liquid costs of an economic adjustment applied upon a country. For that study he used a graphic tool. Generally speaking, we may say that there are two situations: the first one occurs when the country ‘s government decides to apply the adjustments and reforms as soon as distortions appear. The second one happens when the government, in spite of the evidences, muddling through reforms, waits for a society consensus. To illustrate this two different cases, Mexico and Argentina were chosen. Although the graphic tried to show the transitional costs of adjustment, it is possible to deduce other interesting things - basis of this work.