cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.6826802
title: Lung management protocols increase the incidence of lung procurement and organ transplantation: A meta-analysis

description: <b>Background</b>: Improved donor management, including respiratory physiotherapy, may optimize donor suitability and increase successful lung procurement. This review aimed to determine the efficacy of lung management protocols on the incidence of successful lung procurement and transplantation. <b>Methods</b>: Searches were completed in MEDLINE, CINAHL, EMBASE, PubMed, PEDRO, and Cochrane Registry of Controlled Clinical Trials, from database inception to March 2018. Randomized controlled trials and observational studies, with a control or comparison group, of humans, published in English, in peer-reviewed journals were included. Any respiratory management was eligible. Two investigators assessed eligibility and study quality. Meta-analysis and narrative analysis were completed. <b>Results</b>: Ten of 430 articles identified were eligible for inclusion. Implementation of protocols in potential donors increased the incidence of lung procurement, odds ratio (OR), 95% CI: 3.42 (2.48, 4.71) and transplantation procedures OR 2.56 (1.41, 4.62) compared to control groups. Recipient survival was significantly higher, in favor of lung management protocols compared to control groups at 30 days (OR 2.37 (1.14, 4.95)) and 1 year (OR 1.82 (1.02, 3.27)). Pooling of randomized controlled trials was not possible due to heterogeneity between interventions. No studies reported adverse events associated with lung management protocols or the incidence of ventilator-associated pneumonia. Despite differences in intervention design and study quality, observational studies reported consistent direction and magnitude of effects in favor of protocolized interventions. <b>Conclusions</b>: Lung management protocols appear to increase transplantation success. High-quality randomized trials are warranted to test observed effects and ascertain the effects of specific protocol components on transplantation outcomes.
DOI: 10.6084/m9.figshare.6826793
title: raw_data.xlsx

description: Raw data of research to be published soon.
DOI: 10.6084/m9.figshare.6826802.v1
title: Lung management protocols increase the incidence of lung procurement and organ transplantation: A meta-analysis

description: <b>Background</b>: Improved donor management, including respiratory physiotherapy, may optimize donor suitability and increase successful lung procurement. This review aimed to determine the efficacy of lung management protocols on the incidence of successful lung procurement and transplantation. <b>Methods</b>: Searches were completed in MEDLINE, CINAHL, EMBASE, PubMed, PEDRO, and Cochrane Registry of Controlled Clinical Trials, from database inception to March 2018. Randomized controlled trials and observational studies, with a control or comparison group, of humans, published in English, in peer-reviewed journals were included. Any respiratory management was eligible. Two investigators assessed eligibility and study quality. Meta-analysis and narrative analysis were completed. <b>Results</b>: Ten of 430 articles identified were eligible for inclusion. Implementation of protocols in potential donors increased the incidence of lung procurement, odds ratio (OR), 95% CI: 3.42 (2.48, 4.71) and transplantation procedures OR 2.56 (1.41, 4.62) compared to control groups. Recipient survival was significantly higher, in favor of lung management protocols compared to control groups at 30 days (OR 2.37 (1.14, 4.95)) and 1 year (OR 1.82 (1.02, 3.27)). Pooling of randomized controlled trials was not possible due to heterogeneity between interventions. No studies reported adverse events associated with lung management protocols or the incidence of ventilator-associated pneumonia. Despite differences in intervention design and study quality, observational studies reported consistent direction and magnitude of effects in favor of protocolized interventions. <b>Conclusions</b>: Lung management protocols appear to increase transplantation success. High-quality randomized trials are warranted to test observed effects and ascertain the effects of specific protocol components on transplantation outcomes.
DOI: 10.6084/m9.figshare.6826775
title: qPCR in human eosinophils after glucocorticoid exposure

description: Eosinophils were isolated from the peripheral blood of each of five human subjects. Purified eosinophils were then incubated for 4 hours, followed by exposure to dexamethasone (0.5 mcM) or vehicle (culture medium) for an additional 30, 60, or 120 minutes. RNA was purified from each sample and reverse-transcription quantitative real-time PCR (qPCR) was performed on the QuantStudio6 Flex System with the TaqMan Fast Universal PCR Master Mix and FAM-labeled TaqMan gene expression assay sets for human <i>CXCR4</i>, <i>CCR1</i>, <i>XIAP</i>, <i>CCR3</i>, <i>NOTCH1</i>, <i>ZBTB16</i>, <i>PAK1</i>, <i>CASP9</i>, <i>TNFAIP3</i>, <i>BCL2L11</i> and <i>TSC22D3</i>. The gene encoding 18S rRNA was used as an endogenous control. The mean Ct values for each subject, under each condition (dexamethasone or medium), at each time point, were calculated as the mean of two technical replicates, and are presented in the Excel file, with one tab for each gene.
DOI: 10.6084/m9.figshare.6826781
title: Table1.xlsx

description: This table is a list of all museum repositories and their corresponding collection Codens, updated from Johnson & Musetti (2004) and Arnett et al. (1993).<br>This work is supported by U. S. National Science Foundation grants DBI-1356381 and DEB-1353252.
DOI: 10.6084/m9.figshare.6826781.v1
title: Table1.xlsx

description: This table is a list of all museum repositories and their corresponding collection Codens, updated from Johnson & Musetti (2004) and Arnett et al. (1993).<br>This work is supported by U. S. National Science Foundation grants DBI-1356381 and DEB-1353252.
DOI: 10.6084/m9.figshare.6826775.v1
title: qPCR in human eosinophils after glucocorticoid exposure

description: Eosinophils were isolated from the peripheral blood of each of five human subjects. Purified eosinophils were then incubated for 4 hours, followed by exposure to dexamethasone (0.5 mcM) or vehicle (culture medium) for an additional 30, 60, or 120 minutes. RNA was purified from each sample and reverse-transcription quantitative real-time PCR (qPCR) was performed on the QuantStudio6 Flex System with the TaqMan Fast Universal PCR Master Mix and FAM-labeled TaqMan gene expression assay sets for human <i>CXCR4</i>, <i>CCR1</i>, <i>XIAP</i>, <i>CCR3</i>, <i>NOTCH1</i>, <i>ZBTB16</i>, <i>PAK1</i>, <i>CASP9</i>, <i>TNFAIP3</i>, <i>BCL2L11</i> and <i>TSC22D3</i>. The gene encoding 18S rRNA was used as an endogenous control. The mean Ct values for each subject, under each condition (dexamethasone or medium), at each time point, were calculated as the mean of two technical replicates, and are presented in the Excel file, with one tab for each gene.
DOI: 10.6084/m9.figshare.6826151
title: Lehnebach et al 2018

description: <i>This set contains datasets collected and used in the original research article Lehnebach et al 2018 - Wood density variations of Legume trees in French Guiana along the shade tolerance continuum: heartwood effects on radial patterns and gradients</i><br>
DOI: 10.6084/m9.figshare.6826340
title: Supplementary Material for: Development of a Genetic and Clinical Data-Based (GC) Risk Score for Predicting Survival of Hepatocellular Carcinoma Patients After Tumor Resection

description: <b><i>Background/Aims:</i></b> Carnitine palmitoyltransferase 1A (CPT1A) is a rate-limiting enzyme in the transport of long-chain fatty acids for β-oxidation. Increasing evidence has indicated that CPT1A plays an important role in carcinogenesis. However, the expression and prognostic value of CPT1A in hepatocellular carcinoma (HCC) have not been extensively studied. <b><i>Methods:</i></b> Here, we collected 66 post-operative liver cancer tissue samples. Gene profile expression was tested by RT-PCR. Receiver operating characteristic (ROC) analysis was performed and multivariate analysis with Cox’s Proportional Hazard Model was used for confirming the selected markers’ predictive efficiency for HCC patients’ survival. A simple risk scoring system was created based on Cox’s regression modeling and bootstrap internal validation. <b><i>Results:</i></b> Cox multivariate regression analysis demonstrated that CPT1A, tumor size, intrahepatic metastasis, TNM stage and histological grade were independent risk factors for the prognosis of HCC patients after surgery. Our genetic and clinical data-based (GC) risk scoring system revealed that HCC patients whose total score≥3 are more likely to relapse and die than patients whose total score &lt; 3. Finally, the good discriminatory power of our risk scoring model was validated by bootstrap internal validation. <b><i>Conclusions:</i></b> The genetic and clinical data-based risk scoring model can be a promising predictive tool for liver cancer patients’ prognosis after operation.
DOI: 10.6084/m9.figshare.6826151.v1
title: Lehnebach et al 2018

description: <i>This set contains datasets collected and used in the original research article Lehnebach et al 2018 - Wood density variations of Legume trees in French Guiana along the shade tolerance continuum: heartwood effects on radial patterns and gradients</i><br>
DOI: 10.6084/m9.figshare.6826340.v1
title: Supplementary Material for: Development of a Genetic and Clinical Data-Based (GC) Risk Score for Predicting Survival of Hepatocellular Carcinoma Patients After Tumor Resection

description: <b><i>Background/Aims:</i></b> Carnitine palmitoyltransferase 1A (CPT1A) is a rate-limiting enzyme in the transport of long-chain fatty acids for β-oxidation. Increasing evidence has indicated that CPT1A plays an important role in carcinogenesis. However, the expression and prognostic value of CPT1A in hepatocellular carcinoma (HCC) have not been extensively studied. <b><i>Methods:</i></b> Here, we collected 66 post-operative liver cancer tissue samples. Gene profile expression was tested by RT-PCR. Receiver operating characteristic (ROC) analysis was performed and multivariate analysis with Cox’s Proportional Hazard Model was used for confirming the selected markers’ predictive efficiency for HCC patients’ survival. A simple risk scoring system was created based on Cox’s regression modeling and bootstrap internal validation. <b><i>Results:</i></b> Cox multivariate regression analysis demonstrated that CPT1A, tumor size, intrahepatic metastasis, TNM stage and histological grade were independent risk factors for the prognosis of HCC patients after surgery. Our genetic and clinical data-based (GC) risk scoring system revealed that HCC patients whose total score≥3 are more likely to relapse and die than patients whose total score &lt; 3. Finally, the good discriminatory power of our risk scoring model was validated by bootstrap internal validation. <b><i>Conclusions:</i></b> The genetic and clinical data-based risk scoring model can be a promising predictive tool for liver cancer patients’ prognosis after operation.
DOI: 10.6084/m9.figshare.6825986
title: Dataset for the paper Lotka’s law for the Brazilian scientific output published in journals

description: Dataset for the paper Lotka’s law for the Brazilian scientific output published in journals
DOI: 10.6084/m9.figshare.6825986.v1
title: Dataset for the paper Lotka’s law for the Brazilian scientific output published in journals

description: Dataset for the paper Lotka’s law for the Brazilian scientific output published in journals
DOI: 10.15468/ajk7w2
title: Review of Loxopus Townes (Hymenoptera, Ichneumonidae, Cryptinae), with descriptions of six new species

description: This dataset contains the digitized treatments in Plazi based on the original journal article Santos, Bernardo F., Aguiar, Alexandre P. (2014): Review of Loxopus Townes (Hymenoptera, Ichneumonidae, Cryptinae), with descriptions of six new species. Journal of Natural History 49 (31): 1905-1935, DOI: 10.1080/00222933.2014.976669
DOI: 10.6084/m9.figshare.6825932
title: Dataset for the paper Lotka’s law for the Brazilian scientific output published in journals

description: Dataset for the paper Lotka’s law for the Brazilian scientific output published in journals
DOI: 10.6084/m9.figshare.6825932.v1
title: Dataset for the paper Lotka’s law for the Brazilian scientific output published in journals

description: Dataset for the paper Lotka’s law for the Brazilian scientific output published in journals
DOI: 10.6084/m9.figshare.6825905
title: Supplementary Data File 1 (GLMMdata).txt from Behavioural evidence for polychromatic ultraviolet sensitivity in mantis shrimp

description: Supplementary Data File 1 (GLMMdata). The .TXT data file is a tab delimited text file containing the responses and stimulus conditions for all choices made in the trained choice tests. This data set was used to assess the effect of brightness on individual choices in each of the experiments using generalized linear mixed model (GLMM). Column 1 (ans.): 1, correct choice; 0, incorrect choice. Column 2 (ind#): The number designation of each individual used in the experiments. See Table S1. Column 3 (exp.) designates the experiment: 1, UVA vs. UVB; 2, UVB vs. UVA; 3, UVB vs. dark; 4, dark vs. UVB 5, UVA vs. UVA-351; 6, UVA vs. UVA control. Column 4 (bright) designates the relative brightness of the correct stimulus. For experiments 1, 2, 5, and 6: 1, alternate stimulus brighter; 2, correct and alternate stimulus equivalent; 3, correct stimulus brighter. For experiments 3 and 4, where only the correct stimulus was illuminated, the data references the intensity of the correct stimulus, with 5 being the maximum brightness setting.
DOI: 10.6084/m9.figshare.6825896
title: Supplementary Material for: Role of 1α,25-Dihydroxyvitamin D<sub>3</sub> in Adipogenesis of SGBS Cells: New Insights into Human Preadipocyte Proliferation

description: <b><i>Background/Aims:</i></b> Compared with non-obese individuals, obese individuals commonly store more vitamin D in adipose tissue. <i>VDR</i> expression in adipose tissue can influence adipogenesis and is therefore a target pathway deserving further study. This study aims to assess the role of 1,25(OH)<sub>2</sub>D<sub>3</sub> in human preadipocyte proliferation and differentiation. <b><i>Methods:</i></b> RTCA, MTT, and trypan blue assays were used to assess the effects of 1,25(OH)<sub>2</sub>D<sub>3</sub> on the viability, proliferation, and adipogenic differentiation of SGBS cells. Cell cycle and apoptosis analyses were performed with flow cytometry, triglycerides were quantified, and RT-qPCR was used to assess gene expression. <b><i>Results:</i></b> We confirmed that the SGBS cell model is suitable for studying adipogenesis and demonstrated that the differentiation protocol induces cell maturation, thereby increasing the lipid content of cells independently of treatment. 1,25(OH)<sub>2</sub>D<sub>3</sub> treatment had different effects according to the cell stage, indicating different modes of action driving proliferation and differentiation. In preadipocytes, 1,25(OH)<sub>2</sub>D<sub>3</sub> induced G1 growth arrest at both tested concentrations without altering <i>CDKN1A</i> gene expression. Treatment with 100 nM 1,25(OH)<sub>2</sub>D<sub>3</sub> also decreased MTT absorbance and the lipid concentration. Moreover, increased normalized cell index values and decreased metabolic activity were not induced by proliferation or apoptosis. Exposure to 100 nM 1,25(OH)<sub>2</sub>D<sub>3</sub> induced <i>VDR</i>, <i>CEBPA</i>, and <i>CEBPB</i> expression, even in the preadipocyte stage. During adipogenesis, 1,25(OH)<sub>2</sub>D<sub>3</sub> had limited effects on processes such as <i>VDR</i> and <i>PPARG</i> gene expression, but it upregulated <i>CEBPA</i> expression. <b><i>Conclusions:</i></b> We demonstrated for the first time that 1,25(OH)<sub>2</sub>D<sub>3</sub> induces changes in preadipocytes, including <i>VDR</i> expression and growth arrest, and increases the lipid content in adipocytes treated for 16 days. Preadipocytes are important cells in adipose tissue homeostasis, and understanding the role of 1,25(OH)<sub>2</sub>D<sub>3</sub> in adipogenesis is a crucial step in ensuring adequate vitamin D supplementation, especially for obese individuals.
DOI: 10.6084/m9.figshare.6825896.v1
title: Supplementary Material for: Role of 1α,25-Dihydroxyvitamin D<sub>3</sub> in Adipogenesis of SGBS Cells: New Insights into Human Preadipocyte Proliferation

description: <b><i>Background/Aims:</i></b> Compared with non-obese individuals, obese individuals commonly store more vitamin D in adipose tissue. <i>VDR</i> expression in adipose tissue can influence adipogenesis and is therefore a target pathway deserving further study. This study aims to assess the role of 1,25(OH)<sub>2</sub>D<sub>3</sub> in human preadipocyte proliferation and differentiation. <b><i>Methods:</i></b> RTCA, MTT, and trypan blue assays were used to assess the effects of 1,25(OH)<sub>2</sub>D<sub>3</sub> on the viability, proliferation, and adipogenic differentiation of SGBS cells. Cell cycle and apoptosis analyses were performed with flow cytometry, triglycerides were quantified, and RT-qPCR was used to assess gene expression. <b><i>Results:</i></b> We confirmed that the SGBS cell model is suitable for studying adipogenesis and demonstrated that the differentiation protocol induces cell maturation, thereby increasing the lipid content of cells independently of treatment. 1,25(OH)<sub>2</sub>D<sub>3</sub> treatment had different effects according to the cell stage, indicating different modes of action driving proliferation and differentiation. In preadipocytes, 1,25(OH)<sub>2</sub>D<sub>3</sub> induced G1 growth arrest at both tested concentrations without altering <i>CDKN1A</i> gene expression. Treatment with 100 nM 1,25(OH)<sub>2</sub>D<sub>3</sub> also decreased MTT absorbance and the lipid concentration. Moreover, increased normalized cell index values and decreased metabolic activity were not induced by proliferation or apoptosis. Exposure to 100 nM 1,25(OH)<sub>2</sub>D<sub>3</sub> induced <i>VDR</i>, <i>CEBPA</i>, and <i>CEBPB</i> expression, even in the preadipocyte stage. During adipogenesis, 1,25(OH)<sub>2</sub>D<sub>3</sub> had limited effects on processes such as <i>VDR</i> and <i>PPARG</i> gene expression, but it upregulated <i>CEBPA</i> expression. <b><i>Conclusions:</i></b> We demonstrated for the first time that 1,25(OH)<sub>2</sub>D<sub>3</sub> induces changes in preadipocytes, including <i>VDR</i> expression and growth arrest, and increases the lipid content in adipocytes treated for 16 days. Preadipocytes are important cells in adipose tissue homeostasis, and understanding the role of 1,25(OH)<sub>2</sub>D<sub>3</sub> in adipogenesis is a crucial step in ensuring adequate vitamin D supplementation, especially for obese individuals.
DOI: 10.6084/m9.figshare.6825899
title: INER 23.3 Ydersbond Supplemental Material Appendix 1-7 final 17 July.pdf

description: <br>International Negotiation 23(3) (2018) 1–37, "Power through Collaboration: Stakeholder Influence in EU Climate and Energy Negotiations" <br>7 Appendixes:APPENDIX 1 Outline of Causal Mechanisms in Liberal Intergovernmentalism, the Advocacy Coalition Framework and Historical Institutionalism APPENDIX 2 List of Interviews APPENDIX 3 Methodological Considerations Appendix 4 The Policy Core Beliefs of the Three Advocacy Coalitions APPENDIX 5: The EU Member States’ Energy Mixes and Energy Policies, Part 1: Renewable Energy Policy, GHG Emissions Reduction Policy and Coal Policy APPENDIX 6 Overarching Coalitions Based on Similar Political ViewsAppendix 7 Path Dependency in the EU’s Climate and Energy Policy Targets<br> <br>
DOI: 10.6084/m9.figshare.6825596
title: Plant nutritional data from Cradle of Humankind

description: All of the data on the nutritional and antifeedant properties of plants collected in 2014 from five habitats within the Cradle of Humankind World Heritage Site. These data accompany the paper by Henry et al. in the Review of Paleobotany and Palynology.<br>
DOI: 10.6084/m9.figshare.6825596.v1
title: Plant nutritional data from Cradle of Humankind

description: All of the data on the nutritional and antifeedant properties of plants collected in 2014 from five habitats within the Cradle of Humankind World Heritage Site. These data accompany the paper by Henry et al. in the Review of Paleobotany and Palynology.<br>
DOI: 10.6084/m9.figshare.6825521
title: Supplementary Material for: Withdrawal Symptoms after Serotonin-Noradrenaline Reuptake Inhibitor Discontinuation: Systematic Review

description: <b><i>Background:</i></b> Serotonin-noradrenaline reuptake inhibitors (SNRI) are widely used in medical practice. Their discontinuation has been associated with a wide range of symptoms. The aim of this paper is to identify the occurrence, frequency, and features of withdrawal symptoms after SNRI discontinuation. <b><i>Methods:</i></b> PRISMA guidelines were followed to conduct a systematic review. Electronic databases included PubMed, the Cochrane Library, Web of Science, and MEDLINE from the inception of each database to June 2017. Titles, abstracts, and topics were searched using a combination of the following terms: “duloxetine” OR “venlafaxine” OR “desvenlafaxine” OR “milnacipran” OR “levomilnacipran” OR “SNRI” OR “second generation antidepressant” OR “serotonin norepinephrine reuptake inhibitor” AND “discontinuation” OR “withdrawal” OR “rebound.” Only published trials in the English language were included. <b><i>Results:</i></b> Sixty-one reports met the criteria for inclusion. There were 22 double-blind randomized controlled trials, 6 studies where patients were treated in an open fashion and then randomized to a double-blind controlled phase, 8 open trials, 1 prospective naturalistic study, 1 retrospective study, and 23 case reports. Withdrawal symptoms occurred after discontinuation of any type of SNRI. The prevalence of withdrawal symptoms varied across reports and appeared to be higher with venlafaxine. Symptoms typically ensued within a few days from discontinuation and lasted a few weeks, also with gradual tapering. Late onset and/or a longer persistence of disturbances occurred as well. <b><i>Conclusions:</i></b> Clinicians need to add SNRI to the list of drugs potentially inducing withdrawal symptoms upon discontinuation, together with other types of psychotropic drugs. The results of this study challenge the use of SNRI as first-line treatment for mood and anxiety disorders.