cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.12546182.v1
title: Supplementary Material for: Is Fluorescence Technology a Promising Tool for Detecting Infected Dentin in Deep Carious Lesions?

description: The purpose of this study was to determine if the degree of fluorescence detected by fluorescence-aided caries excavation (FACE) correlates with dentin bacterial microbiome diversity, as assessed by 16S rRNA gene amplicon sequencing, and with traditional tactile dentin caries assessment. Unidentified human teeth were obtained from a dental facility. The included teeth had a carious lesion two-thirds into the dentin, verified by radiography, and were red-fluorescing (RF) using FACE technology (SIROInspect; Sirona, Bensheim, Germany). Two independent examiners performed visual/tactile assessment of the lesions. RF sites were sampled with a sterile spoon excavator and dentin characteristics were evaluated. Once RF dentin was removed, a second sample of pink-fluorescing (PF) dentin was obtained. After excavation with a sterile round bur to nonfluorescing (NF) dentin, a third sample was collected with a slow-speed round bur. The samples were processed at the UNC (University of North Carolina at Chapel Hill) Microbiome Core Facility. Out of 134 extracted teeth collected, 21 fit the inclusion criteria, yielding 61 dentin samples. RF samples had the highest number of observed operational taxonomic units (<i>n</i> = 154), followed by PF (<i>n</i> = 109) and NF (<i>n</i> = 100). RF carious dentin was primarily “soft,” and NF dentin was assessed as “hard” 100% of the time by both examiners (rank correlation χ<sup>2</sup>: <i>p</i> &lt; 0.001). However, approximately one-third of the tactile assessments of hard dentin still displayed some fluorescence, either pink or red. We concluded that the sampled fluorescing (RF and PF) and NF carious dentin layers displayed diverse bacterial taxa, and tactile assessments of soft, leathery, and hard corresponded with RF, PF, and NF.
DOI: 10.6084/m9.figshare.12546104
title: Search results of the same search strategy perform in 2 different dates

description: Search results of a Search Strategy executed during the 4th week of January 2020, and was replicated in the 3rd week of June 2020 (June 16, 2020).<br>The search strategy is as follows:SARS-CoV-2 OR SARS-CoV2 OR COVID2019 OR 2019-nCoV OR COVID- 19 OR COVID19 OR 2019-nCoV OR (("novel coronavirus" OR coronavirus OR "new coronavirus") AND (wuhan[tiab])) OR SARS-coronavirus 2[tw] OR “coronavirus 2”[tw] OR "coronavirus disease 2019" OR "2019-novel coronavirus" OR "new coronavirus" OR "COVID-19" [Supplementary Concept] OR "COVID-19 diagnostic testing" [Supplementary Concept] OR "spike glycoprotein, COVID-19 virus" [Supplementary Concept] OR "COVID-19 drug treatment" [Supplementary Concept] OR "LAMP assay" [Supplementary Concept] OR "severe acute respiratory syndrome coronavirus 2" [Supplementary Concept] OR "COVID-19 serotherapy" [Supplementary Concept] OR "COVID-19 vaccine" [Supplementary Concept] NOT ("animals"[MeSH Terms] NOT "humans"[MeSH Terms]) AND ("2019/12/30"[PDat] : "2020/01/05"[PDat])<br><br>
DOI: 10.6084/m9.figshare.12546104.v1
title: Search results of the same search strategy perform in 2 different dates

description: Search results of a Search Strategy executed during the 4th week of January 2020, and was replicated in the 3rd week of June 2020 (June 16, 2020).<br>The search strategy is as follows:SARS-CoV-2 OR SARS-CoV2 OR COVID2019 OR 2019-nCoV OR COVID- 19 OR COVID19 OR 2019-nCoV OR (("novel coronavirus" OR coronavirus OR "new coronavirus") AND (wuhan[tiab])) OR SARS-coronavirus 2[tw] OR “coronavirus 2”[tw] OR "coronavirus disease 2019" OR "2019-novel coronavirus" OR "new coronavirus" OR "COVID-19" [Supplementary Concept] OR "COVID-19 diagnostic testing" [Supplementary Concept] OR "spike glycoprotein, COVID-19 virus" [Supplementary Concept] OR "COVID-19 drug treatment" [Supplementary Concept] OR "LAMP assay" [Supplementary Concept] OR "severe acute respiratory syndrome coronavirus 2" [Supplementary Concept] OR "COVID-19 serotherapy" [Supplementary Concept] OR "COVID-19 vaccine" [Supplementary Concept] NOT ("animals"[MeSH Terms] NOT "humans"[MeSH Terms]) AND ("2019/12/30"[PDat] : "2020/01/05"[PDat])<br><br>
DOI: 10.6084/m9.figshare.12546065
title: Supplementary Material for: Health-Related Quality of Life in Patients with Multiple Endocrine Neoplasia Type 1

description: <b><i>Introduction:</i></b> Multiple endocrine neoplasia type 1 (MEN1) is a hereditary endocrine tumor syndrome characterized by the triad of primary hyperparathyroidism, duodenopancreatic neuroendocrine tumors (pNETs), and pituitary tumors. Patients are confronted with substantial morbidity and are consequently at risk for an impaired quality of life (QOL). Meticulous assessment of QOL and associated factors in a representative population is needed to understand the full spectrum of the burden of the disease. <b><i>Patients and Methods:</i></b> A cross-sectional study was performed using the national Dutch MEN1 cohort. Patients with a confirmed MEN1 mutation received the SF-36 Health Related Quality of Life questionnaire and questions regarding sociodemographic and medical history. <b><i>Results:</i></b> A total of 227 of 285 (80%) eligible MEN1 patients returned the questionnaires. Health-related QOL scores (HRQOL) in MEN1 patients were significantly lower for the majority of subscales of the SF-36 in comparison with the general Dutch population. The most consistent predictor for HRQOL was employment status, followed by the presence of a pituitary tumor. 16% of patients harboring a pNET and 29% of patients with a pituitary tumor according to the medical records, reported that they were unaware of such a tumor. These subgroups of patients had several significant better QOL scores than patients who were aware of their pNET or pituitary tumors. <b><i>Conclusion:</i></b> Patients with MEN1 have an impaired QOL in comparison with the general Dutch population warranting special attention within routine care. For daily practice, physicians should be aware of their patients’ impaired QOL and of the impact of unemployment on QOL.
DOI: 10.6084/m9.figshare.12546074
title: Fracture geometries

description: Three tuff fracture geometries scanned and processed by The University of Texas at Austin
DOI: 10.6084/m9.figshare.12545999
title: Supplementary Material for: Clinical Phenotype of <b><i>LRRK2</i></b> R1441C in 2 Chinese Sisters

description: Pathogenic and risk variants in the <i>LRRK2</i> gene are among the main genetic contributors to Parkinson’s disease (PD) worldwide, and LRRK2-targeted therapies for patients with PARK-<i>LRRK2</i>are now entering clinical trials. However, in contrast to the <i>LRRK2</i> G2019S mutation commonly found in Caucasians, North-African Arabs, and Ashkenazi Jews, relatively little is known about other causative <i>LRRK2</i> mutations, and data on genotype-phenotype correlations are largely lacking. This report is from an ongoing multicentre study in which next-generation sequencing-based PD gene panel testing has so far been conducted on 499 PD patients of various ethnicities from Malaysia. We describe 2 sisters of Chinese ancestry with PD who carry the R1441C mutation in <i>LRRK2</i> (which in Asians has been reported in only 2 Chinese patients previously), and highlight interesting clinical observations made over a decade of close follow-up. We further explored the feasibility of using a brief, expert-administered rating scale (the Clinical Impression of Severity Index; CISI-PD) to capture data on global disease severity in a large (<i>n</i> = 820) unselected cohort of PD patients, including severely disabled individuals typically excluded from research studies. All patients in this study were managed and evaluated by the same PD neurologist, and these data were used to make broad comparisons between the monogenic PD cases versus the overall “real world” PD cohort. This report contributes to the scarce literature on R1441C PARK-<i>LRRK2</i>, offering insights into natural history and epidemiological aspects, and provides support for the application of a simple and reliable clinical tool that can improve the inclusion of under-represented patient groups in PD research.
DOI: 10.6084/m9.figshare.12545996
title: East Asian common octopus (Octopus sinensis) genome supporting data

description: This dataset is the gene annotion data for the East Asian common octopus (octopus sinensis) genome
DOI: 10.6084/m9.figshare.12545999.v1
title: Supplementary Material for: Clinical Phenotype of <b><i>LRRK2</i></b> R1441C in 2 Chinese Sisters

description: Pathogenic and risk variants in the <i>LRRK2</i> gene are among the main genetic contributors to Parkinson’s disease (PD) worldwide, and LRRK2-targeted therapies for patients with PARK-<i>LRRK2</i>are now entering clinical trials. However, in contrast to the <i>LRRK2</i> G2019S mutation commonly found in Caucasians, North-African Arabs, and Ashkenazi Jews, relatively little is known about other causative <i>LRRK2</i> mutations, and data on genotype-phenotype correlations are largely lacking. This report is from an ongoing multicentre study in which next-generation sequencing-based PD gene panel testing has so far been conducted on 499 PD patients of various ethnicities from Malaysia. We describe 2 sisters of Chinese ancestry with PD who carry the R1441C mutation in <i>LRRK2</i> (which in Asians has been reported in only 2 Chinese patients previously), and highlight interesting clinical observations made over a decade of close follow-up. We further explored the feasibility of using a brief, expert-administered rating scale (the Clinical Impression of Severity Index; CISI-PD) to capture data on global disease severity in a large (<i>n</i> = 820) unselected cohort of PD patients, including severely disabled individuals typically excluded from research studies. All patients in this study were managed and evaluated by the same PD neurologist, and these data were used to make broad comparisons between the monogenic PD cases versus the overall “real world” PD cohort. This report contributes to the scarce literature on R1441C PARK-<i>LRRK2</i>, offering insights into natural history and epidemiological aspects, and provides support for the application of a simple and reliable clinical tool that can improve the inclusion of under-represented patient groups in PD research.
DOI: 10.6084/m9.figshare.12545963
title: Supplementary Material for: Arm Span and Its Relation to Height in a 2- to 17-Year-Old Reference Population and Heterozygous Carriers of <b><i>ACAN</i></b> Variants

description: <b><i>Background/Objectives:</i></b> In the clinical assessment of a short or tall child, estimating body disproportion is useful to assess the likelihood of a primary growth disorder, e.g., skeletal dysplasia. Our objectives were (1) to use data from the Maastricht study on healthy children (2–17 years) to calculate relative arm span (AS) for height (H) to serve as age references for clinical purposes; (2) to assess its age and sex dependency; and (3) to investigate relative AS adjustment for age and sex in individuals with <i>ACAN</i> haploinsufficiency. <b><i>Methods:</i></b> The Maastricht study data (2,595 Caucasian children, 52% boys, 48% girls) were re-analysed to produce reference tables and graphs for age and sex of AS – H and AS/H. Published information on AS/H in Europeans was used as reference data for adults. Relative AS from 33 patients with <i>ACAN</i> haploinsufficiency were plotted against reference data and expressed as standard deviation score (SDS) for age and sex. <b><i>Results:</i></b> Mean AS – H from 2 to 17 years increased from –1.2 to +1.5 cm in boys and from –4.8 to +1.6 cm in girls. Mean AS/H increased from 0.9848 to 1.0155 in boys and from 0.9468 to 1.0028 in girls. Mean AS/H in patients with <i>ACAN</i> haploinsufficiency was approximately 1.0, 1.5 and 0.5 SDS in young children, adolescents and 20- to 50-year-olds, respectively, and normal thereafter. <b><i>Conclusions:</i></b> These reference charts can be used for 2- to 17-year-old children/adolescents. Carriers of <i>ACAN</i> haploinsufficiency have an elevated mean AS/H in childhood and adolescence and a slightly elevated ratio till 50 years.
DOI: 10.6084/m9.figshare.12545975
title: KEGG_build_2020-04-27.tar.gz

description: An archived version of the KEGG data directory for use in anvi'o. Can be set up on a computer with an anvi'o installation using the command `anvi-setup-kegg-kofams --kegg-archive KEGG_build_2020-04-27.tar.gz` (specify a --kegg-data-dir to avoid overriding the default KEGG data directory, if one exists).<br>
DOI: 10.6084/m9.figshare.12545957
title: Whole-genome analyses reveal gene content differences between nontypeable Haemophilus influenzae isolates from chronic obstructive pulmonary disease compared to other clinical phenotypes

description: Supplementary Material and Supplementary data for ‘Whole-genome analyses reveal gene content differences between nontypeable Haemophilus influenzae isolates from chronic obstructive pulmonary disease compared to other clinical phenotypes’ as published in Microbial Genomics.
DOI: 10.6084/m9.figshare.12545975.v1
title: KEGG_build_2020-04-27.tar.gz

description: An archived version of the KEGG data directory for use in anvi'o. Can be set up on a computer with an anvi'o installation using the command `anvi-setup-kegg-kofams --kegg-archive KEGG_build_2020-04-27.tar.gz` (specify a --kegg-data-dir to avoid overriding the default KEGG data directory, if one exists).<br>
DOI: 10.6084/m9.figshare.12545963.v1
title: Supplementary Material for: Arm Span and Its Relation to Height in a 2- to 17-Year-Old Reference Population and Heterozygous Carriers of <b><i>ACAN</i></b> Variants

description: <b><i>Background/Objectives:</i></b> In the clinical assessment of a short or tall child, estimating body disproportion is useful to assess the likelihood of a primary growth disorder, e.g., skeletal dysplasia. Our objectives were (1) to use data from the Maastricht study on healthy children (2–17 years) to calculate relative arm span (AS) for height (H) to serve as age references for clinical purposes; (2) to assess its age and sex dependency; and (3) to investigate relative AS adjustment for age and sex in individuals with <i>ACAN</i> haploinsufficiency. <b><i>Methods:</i></b> The Maastricht study data (2,595 Caucasian children, 52% boys, 48% girls) were re-analysed to produce reference tables and graphs for age and sex of AS – H and AS/H. Published information on AS/H in Europeans was used as reference data for adults. Relative AS from 33 patients with <i>ACAN</i> haploinsufficiency were plotted against reference data and expressed as standard deviation score (SDS) for age and sex. <b><i>Results:</i></b> Mean AS – H from 2 to 17 years increased from –1.2 to +1.5 cm in boys and from –4.8 to +1.6 cm in girls. Mean AS/H increased from 0.9848 to 1.0155 in boys and from 0.9468 to 1.0028 in girls. Mean AS/H in patients with <i>ACAN</i> haploinsufficiency was approximately 1.0, 1.5 and 0.5 SDS in young children, adolescents and 20- to 50-year-olds, respectively, and normal thereafter. <b><i>Conclusions:</i></b> These reference charts can be used for 2- to 17-year-old children/adolescents. Carriers of <i>ACAN</i> haploinsufficiency have an elevated mean AS/H in childhood and adolescence and a slightly elevated ratio till 50 years.
DOI: 10.6084/m9.figshare.12545747
title: Tempdata

description: This is testing dataset<br>
DOI: 10.6084/m9.figshare.12545957.v2
title: Whole-genome analyses reveal gene content differences between nontypeable Haemophilus influenzae isolates from chronic obstructive pulmonary disease compared to other clinical phenotypes

description: Supplementary Material and Supplementary data for ‘Whole-genome analyses reveal gene content differences between nontypeable Haemophilus influenzae isolates from chronic obstructive pulmonary disease compared to other clinical phenotypes’ as published in Microbial Genomics.
DOI: 10.6084/m9.figshare.12545747.v1
title: Tempdata

description: This is testing dataset<br>
DOI: 10.6084/m9.figshare.12545936
title: Supplementary Material for: Pulse Wave Analysis and Pulse Wave Velocity for Fistula Assessment

description: <b><i>Background/Aims:</i></b> Pulse wave analysis (PWA) and pulse wave velocity (PWV) provide information about arterial stiffness and elasticity, which is mainly used for cardiovascular risk stratification. In the presented prospective observational pilot study, we examined the hypothesis that radiocephalic fistula (RCF)-related changes of haemodynamics and blood vessel morphology including high as well as low flow can be seen in specific changes of pulse wave (PW) morphology. <b><i>Methods:</i></b> Fifty-six patients with RCF underwent local ambilateral peripheral PWA and PWV measurement with the SphygmoCor® device. Given that the output parameters of the SphygmoCor® are not relevant for the study objectives, we defined new suitable parameters for PWA in direct proximity to fistulas and established an appropriate analysing algorithm. Duplex sonography served as reference method. <b><i>Results:</i></b> Marked changes of peripheral PW morphology when considering interarm differences of slope and areas between the fistula and non-fistula arms were observed in the Arteria radialis, A. brachialis and arterialized Vena cephalica. The sum of the slope differences was found to correlate with an increased flow, while in patients with fistula failure no changes in PW morphology were seen. Moreover, PWV was significantly reduced in the fistula arm. <b><i>Conclusion:</i></b> Beside duplex sonography, ambilateral peripheral PWA and PWV measurements are potential new clinical applications to characterize and monitor RCF function, especially in terms of high and low flow.
DOI: 10.6084/m9.figshare.12545633
title: Shahab et al. (2020). Dataset with anonymized sprint and F-v-P data per individiual for artificial turf and concrete surfaces

description: Anonymized sprint and F-v-P data per individiual
DOI: 10.6084/m9.figshare.12545936.v1
title: Supplementary Material for: Pulse Wave Analysis and Pulse Wave Velocity for Fistula Assessment

description: <b><i>Background/Aims:</i></b> Pulse wave analysis (PWA) and pulse wave velocity (PWV) provide information about arterial stiffness and elasticity, which is mainly used for cardiovascular risk stratification. In the presented prospective observational pilot study, we examined the hypothesis that radiocephalic fistula (RCF)-related changes of haemodynamics and blood vessel morphology including high as well as low flow can be seen in specific changes of pulse wave (PW) morphology. <b><i>Methods:</i></b> Fifty-six patients with RCF underwent local ambilateral peripheral PWA and PWV measurement with the SphygmoCor® device. Given that the output parameters of the SphygmoCor® are not relevant for the study objectives, we defined new suitable parameters for PWA in direct proximity to fistulas and established an appropriate analysing algorithm. Duplex sonography served as reference method. <b><i>Results:</i></b> Marked changes of peripheral PW morphology when considering interarm differences of slope and areas between the fistula and non-fistula arms were observed in the Arteria radialis, A. brachialis and arterialized Vena cephalica. The sum of the slope differences was found to correlate with an increased flow, while in patients with fistula failure no changes in PW morphology were seen. Moreover, PWV was significantly reduced in the fistula arm. <b><i>Conclusion:</i></b> Beside duplex sonography, ambilateral peripheral PWA and PWV measurements are potential new clinical applications to characterize and monitor RCF function, especially in terms of high and low flow.
DOI: 10.6084/m9.figshare.12545957.v1
title: Whole-genome analyses reveal gene content differences between nontypeable Haemophilus influenzae isolates from chronic obstructive pulmonary disease compared to other clinical phenotypes

description: Supplementary Material and Supplementary data for ‘Whole-genome analyses reveal gene content differences between nontypeable Haemophilus influenzae isolates from chronic obstructive pulmonary disease compared to other clinical phenotypes’ as published in Microbial Genomics.
DOI: 10.6084/m9.figshare.12545633.v2
title: Shahab et al. (2020). Dataset with anonymized sprint and F-v-P data per individiual for artificial turf and concrete surfaces

description: Anonymized sprint and F-v-P data per individiual
DOI: 10.6084/m9.figshare.12545069
title: Additional file 1 of Sustainable land management interventions lead to carbon sequestration in plant biomass and soil in a mixed crop-livestock system: the case of Geda watershed, central highlands of Ethiopia

description: Additional file 1. Data.
DOI: 10.6084/m9.figshare.12545633.v1
title: Anonymized sprint and F-v-P data per individiual

description: Anonymized sprint and F-v-P data per individiual
DOI: 10.6084/m9.figshare.12545069.v1
title: Additional file 1 of Sustainable land management interventions lead to carbon sequestration in plant biomass and soil in a mixed crop-livestock system: the case of Geda watershed, central highlands of Ethiopia

description: Additional file 1. Data.
DOI: 10.6084/m9.figshare.12544925
title: Additional file 1 of Molecular identification of a Heterorhabditis entomopathogenic nematode isolated from the northernmost region of South Africa

description: Additional file 1: Figure S1. Morphological features of the isolate showing a tessellate pattern in anterior most region (a). Lateral field with two ridges (b). Prominent cuticular dorsal tooth present (c, d, and e).
DOI: 10.6084/m9.figshare.12544925.v1
title: Additional file 1 of Molecular identification of a Heterorhabditis entomopathogenic nematode isolated from the northernmost region of South Africa

description: Additional file 1: Figure S1. Morphological features of the isolate showing a tessellate pattern in anterior most region (a). Lateral field with two ridges (b). Prominent cuticular dorsal tooth present (c, d, and e).
DOI: 10.6084/m9.figshare.12544868
title: Additional file 1 of Multi-level validation of the German physical activity self-efficacy scale in a sample of female sixth-graders

description: Additional file 1. validation data; description: minimal dataset necessary to replicate the analysis.
DOI: 10.6084/m9.figshare.12544868.v1
title: Additional file 1 of Multi-level validation of the German physical activity self-efficacy scale in a sample of female sixth-graders

description: Additional file 1. validation data; description: minimal dataset necessary to replicate the analysis.