cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.21624496
title: Chromatographic profile of xanthones and flavonoids in the anti-dengue extracts of Fridericia samydoides (Cham.) L.G. Lohmann (Bignoniaceae)

description: Abstract The flavonoids and xanthones present in the ethanol extracts of leaves and stems of Fridericia samydoides showed that anti-dengue activities in vitro were investigated qualitatively by liquid chromatography-ultraviolet-mass spectrometry in series. Nineteen flavones and fifteen xanthones were detected and characterized on the basis of their fragmentation pattern in the positive and negative ion mode tandem mass spectrometry spectra and ultraviolet bands. Acacetin, chrysin, vitexin, isovitexin, orientin, isoorientin, mangiferin, 2’-O-trans-caffeoylmangiferin, 2’-O-trans-coumaroylmangiferin and 2’-O-trans-cinnamoylmangiferin were identified by comparison with authentic samples. The other compounds detected were tentatively assigned by analysis of the spectral data and by comparison with literature reports. In addition, it performed the fractionation of the leaves extract leading to the isolation of mangiferin, isovitexin and isoorientin. All extracts and isolated compounds inhibited the Dengue virus replication cycle with EC50 less than 25.0 µg/mL for extracts and 272.5, 85.6 and 79.3 µg/mL for mangiferin, isovitexin and isoorientin, respectively.
DOI: 10.6084/m9.figshare.21624496.v1
title: Chromatographic profile of xanthones and flavonoids in the anti-dengue extracts of Fridericia samydoides (Cham.) L.G. Lohmann (Bignoniaceae)

description: Abstract The flavonoids and xanthones present in the ethanol extracts of leaves and stems of Fridericia samydoides showed that anti-dengue activities in vitro were investigated qualitatively by liquid chromatography-ultraviolet-mass spectrometry in series. Nineteen flavones and fifteen xanthones were detected and characterized on the basis of their fragmentation pattern in the positive and negative ion mode tandem mass spectrometry spectra and ultraviolet bands. Acacetin, chrysin, vitexin, isovitexin, orientin, isoorientin, mangiferin, 2’-O-trans-caffeoylmangiferin, 2’-O-trans-coumaroylmangiferin and 2’-O-trans-cinnamoylmangiferin were identified by comparison with authentic samples. The other compounds detected were tentatively assigned by analysis of the spectral data and by comparison with literature reports. In addition, it performed the fractionation of the leaves extract leading to the isolation of mangiferin, isovitexin and isoorientin. All extracts and isolated compounds inhibited the Dengue virus replication cycle with EC50 less than 25.0 µg/mL for extracts and 272.5, 85.6 and 79.3 µg/mL for mangiferin, isovitexin and isoorientin, respectively.
DOI: 10.6084/m9.figshare.21624499
title: Doctors and outsourcing: perceptions of workers and managers on recent transformations in the labor market

description: Abstract The article examines recent trends in the way doctors enter the labor market in the light of the regulation of labor relations in the perception of key informants who work in the public and private sectors of the health system in the state of São Paulo, Brazil. The study showed that, in the perception of the interviewees, there is a growing trend of insertion of doctors as a legal entity conditioned by the regulation of labor relations and the contracting policy of establishments providing health care services. In general, the ‘pejotização’ (hiring free of labor rights/illegal hiring) of doctors was associated with the loss of autonomy of these professionals in relation to the terms of employment and the conditions for performing the work. The article concludes that the illegal hiring and insertion of doctors is presented as part of the more general movement of cheapening the workforce associated with outsourcing, and indicates that there is room for the exploitation of policies aimed at the management of workers who seek to attract and fix doctors in the Unified Health System.
DOI: 10.6084/m9.figshare.21624499.v1
title: Doctors and outsourcing: perceptions of workers and managers on recent transformations in the labor market

description: Abstract The article examines recent trends in the way doctors enter the labor market in the light of the regulation of labor relations in the perception of key informants who work in the public and private sectors of the health system in the state of São Paulo, Brazil. The study showed that, in the perception of the interviewees, there is a growing trend of insertion of doctors as a legal entity conditioned by the regulation of labor relations and the contracting policy of establishments providing health care services. In general, the ‘pejotização’ (hiring free of labor rights/illegal hiring) of doctors was associated with the loss of autonomy of these professionals in relation to the terms of employment and the conditions for performing the work. The article concludes that the illegal hiring and insertion of doctors is presented as part of the more general movement of cheapening the workforce associated with outsourcing, and indicates that there is room for the exploitation of policies aimed at the management of workers who seek to attract and fix doctors in the Unified Health System.
DOI: 10.6084/m9.figshare.21601207
title: A new species of Harttia from the rio São Francisco basin (Siluriformes: Loricariidae)

description: Abstract The genus Harttia belongs to the subfamily Loricariinae and has to date 27 described species, distributed in the drainages of Guiana Shield, Amazon and southeastern Brazil. The new species is distinguished from its congeners by the combination of: canal plate present; abdominal plates absent; trapezoid preanal plates; males with elongated and conspicuous odontodes on the first pectoral-fin ray and on the lateral region of the head, close to the canal plate; and dorsal-fin spinelet present. An identification key for the species of the rio São Francisco basin and a comparison between the new taxon and all other species of the genus are presented.
DOI: 10.6084/m9.figshare.21601207.v1
title: A new species of Harttia from the rio São Francisco basin (Siluriformes: Loricariidae)

description: Abstract The genus Harttia belongs to the subfamily Loricariinae and has to date 27 described species, distributed in the drainages of Guiana Shield, Amazon and southeastern Brazil. The new species is distinguished from its congeners by the combination of: canal plate present; abdominal plates absent; trapezoid preanal plates; males with elongated and conspicuous odontodes on the first pectoral-fin ray and on the lateral region of the head, close to the canal plate; and dorsal-fin spinelet present. An identification key for the species of the rio São Francisco basin and a comparison between the new taxon and all other species of the genus are presented.
DOI: 10.6084/m9.figshare.21624504
title: Shiatsu-associated physical therapy on pain and fatigue on people with multiple sclerosis

description: Abstract Introduction: Pain and fatigue are common symptoms in multiple sclerosis (MS). Shiatsu, a technique that uses the pressure of fingers, associated with manual therapy, exercises and stretching can be used to control these symptoms. Objective: To evaluate the effect of Shiatsu associated with physical therapy on pain and fatigue on people with MS. Methods: Randomized clinical trial with people diagnosed with MS divided into two groups: intervention group (IG) - Shiatsu-associated physical therapy (n = 9), and control group (CG, n = 8). Participants were assessed before and after treatment by the Expanded Disability Status Scale (EDSS), Neuropathic Pain Questionnaire (DN4), Visual Analog Scale (VAS) and Fatigue Impact Scale (MFIS), and description of sociodemographic. Results: Seventeen people with MS (9 men) aged 45.18 ± 3.06 years participated in this study. In the total sample, the average of DN4 was 1.65 ± 20.02, VAS was 2.29 ± 2.80, MFIS was 39.47 ± 29.67, and 52.9 % had a score &gt; 38 in the MFIS that corresponds to presence of fatigue. The values pre/post-intervention/grade of p, respectively in the IG were DN4: 2.78 ± 2.16/2.0 ± 2.12/0.432, EVA: 3.22 ± 3.27/0.33 ± 1.00/0.023, total MFIS: 44.44 ± 35.91/35 ± 31.70/0.068. In the CG the values were DN4 : 0.38 ± 0.744/2.25 ± 2.71/0.054, EVA : 1.25 ± 1.83/3.63 ± 2.38/0.043, and MFIS : 33.88 ± 21.68/25.13 ± 24.22/0.379. Conclusion: Shiatsu associated with Physiotherapy was effective in improving pain and fatigue in individuals with MS.
DOI: 10.6084/m9.figshare.21624504.v1
title: Shiatsu-associated physical therapy on pain and fatigue on people with multiple sclerosis

description: Abstract Introduction: Pain and fatigue are common symptoms in multiple sclerosis (MS). Shiatsu, a technique that uses the pressure of fingers, associated with manual therapy, exercises and stretching can be used to control these symptoms. Objective: To evaluate the effect of Shiatsu associated with physical therapy on pain and fatigue on people with MS. Methods: Randomized clinical trial with people diagnosed with MS divided into two groups: intervention group (IG) - Shiatsu-associated physical therapy (n = 9), and control group (CG, n = 8). Participants were assessed before and after treatment by the Expanded Disability Status Scale (EDSS), Neuropathic Pain Questionnaire (DN4), Visual Analog Scale (VAS) and Fatigue Impact Scale (MFIS), and description of sociodemographic. Results: Seventeen people with MS (9 men) aged 45.18 ± 3.06 years participated in this study. In the total sample, the average of DN4 was 1.65 ± 20.02, VAS was 2.29 ± 2.80, MFIS was 39.47 ± 29.67, and 52.9 % had a score &gt; 38 in the MFIS that corresponds to presence of fatigue. The values pre/post-intervention/grade of p, respectively in the IG were DN4: 2.78 ± 2.16/2.0 ± 2.12/0.432, EVA: 3.22 ± 3.27/0.33 ± 1.00/0.023, total MFIS: 44.44 ± 35.91/35 ± 31.70/0.068. In the CG the values were DN4 : 0.38 ± 0.744/2.25 ± 2.71/0.054, EVA : 1.25 ± 1.83/3.63 ± 2.38/0.043, and MFIS : 33.88 ± 21.68/25.13 ± 24.22/0.379. Conclusion: Shiatsu associated with Physiotherapy was effective in improving pain and fatigue in individuals with MS.
DOI: 10.6084/m9.figshare.21624505
title: Metabolomics approach: Interpretation of changes in rat plasma metabolites after solifenacin treatment

description: Abstract Changes in metabolite levels of patients using the long-term drug can be comprehensively demonstrated by pharmacometabolomic studies. In this study, biological alterations induced by the administration of solifenacin succinate were investigated with a pharmacometabolomics approach on rat metabolism. Plasma samples obtained from rats were analyzed by LC-Q- TOF/MS/MS. METLIN and HMDB databases were used to identify metabolites. Data were processed and classified with MATLAB 2017b. 53 m/z values were found to be significantly different between the drug and control groups (p ≤ 0.01 and fold analysis &gt; 1.5) and identified by comparing METLIN and HMDB databases. According to multivariate data analysis, changes in arachidonic acid, thromboxane A2, palmitic acid, choline, calcitriol, histamine phosphate, retinyl ester, l-cysteine, l-leucine, beta-alanine, l-histidine levels were found to be statistically significant compare to the control group. Differences in the biosynthesis of phenylalanine, aminoacyl-tRNA, tyrosine, tryptophan, metabolism of glycerophospholipid, cysteine, methionine, histidine, arachidonic metabolism have been successfully demonstrated by the metabolomics approach. Our study provides important information to explain the efficacy and toxicity of chronic administration of solifenacin succinate.
DOI: 10.6084/m9.figshare.21624505.v1
title: Metabolomics approach: Interpretation of changes in rat plasma metabolites after solifenacin treatment

description: Abstract Changes in metabolite levels of patients using the long-term drug can be comprehensively demonstrated by pharmacometabolomic studies. In this study, biological alterations induced by the administration of solifenacin succinate were investigated with a pharmacometabolomics approach on rat metabolism. Plasma samples obtained from rats were analyzed by LC-Q- TOF/MS/MS. METLIN and HMDB databases were used to identify metabolites. Data were processed and classified with MATLAB 2017b. 53 m/z values were found to be significantly different between the drug and control groups (p ≤ 0.01 and fold analysis &gt; 1.5) and identified by comparing METLIN and HMDB databases. According to multivariate data analysis, changes in arachidonic acid, thromboxane A2, palmitic acid, choline, calcitriol, histamine phosphate, retinyl ester, l-cysteine, l-leucine, beta-alanine, l-histidine levels were found to be statistically significant compare to the control group. Differences in the biosynthesis of phenylalanine, aminoacyl-tRNA, tyrosine, tryptophan, metabolism of glycerophospholipid, cysteine, methionine, histidine, arachidonic metabolism have been successfully demonstrated by the metabolomics approach. Our study provides important information to explain the efficacy and toxicity of chronic administration of solifenacin succinate.
DOI: 10.6084/m9.figshare.21624507
title: Quality of Life of Elderly People Living in Different Types of Long-term Care Facilities

description: Abstract Population aging is a worldwide occurrence that has become urgent in developing countries. Quality of life can be measured to identify functional capacity and determine the degree of impact on quality of life exerted on an individual. This study aimed to measure the quality of life of elderly people who have been living in different long-term care facilities for the elderly. Therefore, this research was developed with a qualitative and descriptive approach. Data were obtained from medical records and interviews, and were analyzed in R language interpreter software on the Ubuntu Linux operating system. Seventy-nine elderly people participated in the study. Eleven lived in Home Marista, and 68 lived in Home Jesus Maria José. A socioeconomic questionnaire was used to collect data on the socioeconomic characteristics of the participants. The Mini-Mental State Exam was used to measure degree of cognition. The Short Form-36 Questionnaire was used to measure quality of life. The present study suggests that the results found can clarify the individual vulnerability of the elderly in the age group studied regardless of the type of residence. Despite the discrepancy found regarding the care provided at the long-term care facilities, the scores, obtained with the quality of life assessment, did not show significant differences.
DOI: 10.6084/m9.figshare.21624507.v1
title: Quality of Life of Elderly People Living in Different Types of Long-term Care Facilities

description: Abstract Population aging is a worldwide occurrence that has become urgent in developing countries. Quality of life can be measured to identify functional capacity and determine the degree of impact on quality of life exerted on an individual. This study aimed to measure the quality of life of elderly people who have been living in different long-term care facilities for the elderly. Therefore, this research was developed with a qualitative and descriptive approach. Data were obtained from medical records and interviews, and were analyzed in R language interpreter software on the Ubuntu Linux operating system. Seventy-nine elderly people participated in the study. Eleven lived in Home Marista, and 68 lived in Home Jesus Maria José. A socioeconomic questionnaire was used to collect data on the socioeconomic characteristics of the participants. The Mini-Mental State Exam was used to measure degree of cognition. The Short Form-36 Questionnaire was used to measure quality of life. The present study suggests that the results found can clarify the individual vulnerability of the elderly in the age group studied regardless of the type of residence. Despite the discrepancy found regarding the care provided at the long-term care facilities, the scores, obtained with the quality of life assessment, did not show significant differences.
DOI: 10.6084/m9.figshare.21624513
title: Effectiveness of the contrast technique as recovery after effort according to professional athletes

description: Abstract Introduction: Alterations caused in the metabolism of those who practice physical exercise regularly generate health benefits, however, in athletes, these alterations can cause muscle damage, so post-recovery recovery methods are extremely important for their physiological maintenance. Objective: To analyze the effectiveness of the contrast therapy technique with post-exercise recovery according to professional athletes. Methods: A questionnaire was applied that addressed the technical scientific knowledge of professional athletes over 18 years of age, of both sexes, about post-exerciseffort recovery techniques (PERT), personal information, and ethical issues, on an online platform. Descriptive statistical analysis was performed, with values presented in percentages and an association through the Chi-Square test on the knowledge of PERT and other independent variables. Results: In total, 63 athletes, 15 women and 48 men, answered the online questionnaire, 71.4% were between 18 and 30 years old, including swimmers, footballers, and athletics practitioners, and 85.7% had more than three years' experience in the sport and 57.1% competed at an international level. Considering the main PERTs, 92.1% were aware, 58.7% knew more than four, 96.8% frequently used at least one PERT, and 65.1% had used it for more than three years. Knowledge of PERTs is associated with age (p = 0.001), education (p = 0.001), practice time (p = 0.001), hours of daily training (0.001), and competitive level (p = 0.03). With respect to the use of the contrast technique, 36.5% of the respondents had already used it, and 34.9% found it effective. Conclusion: The athletes who used the contrast technique reported a good perception of recovery.
DOI: 10.6084/m9.figshare.21624513.v1
title: Effectiveness of the contrast technique as recovery after effort according to professional athletes

description: Abstract Introduction: Alterations caused in the metabolism of those who practice physical exercise regularly generate health benefits, however, in athletes, these alterations can cause muscle damage, so post-recovery recovery methods are extremely important for their physiological maintenance. Objective: To analyze the effectiveness of the contrast therapy technique with post-exercise recovery according to professional athletes. Methods: A questionnaire was applied that addressed the technical scientific knowledge of professional athletes over 18 years of age, of both sexes, about post-exerciseffort recovery techniques (PERT), personal information, and ethical issues, on an online platform. Descriptive statistical analysis was performed, with values presented in percentages and an association through the Chi-Square test on the knowledge of PERT and other independent variables. Results: In total, 63 athletes, 15 women and 48 men, answered the online questionnaire, 71.4% were between 18 and 30 years old, including swimmers, footballers, and athletics practitioners, and 85.7% had more than three years' experience in the sport and 57.1% competed at an international level. Considering the main PERTs, 92.1% were aware, 58.7% knew more than four, 96.8% frequently used at least one PERT, and 65.1% had used it for more than three years. Knowledge of PERTs is associated with age (p = 0.001), education (p = 0.001), practice time (p = 0.001), hours of daily training (0.001), and competitive level (p = 0.03). With respect to the use of the contrast technique, 36.5% of the respondents had already used it, and 34.9% found it effective. Conclusion: The athletes who used the contrast technique reported a good perception of recovery.
DOI: 10.6084/m9.figshare.21624516
title: A CLUSTERING-BASED APPROACH FOR IDENTIFYING GROUPS OF MUNICIPALITIES TO SUPPORT THE DIRECTION OF PUBLIC SECURITY POLICIES

description: ABSTRACT The direction of public policies plays an important role in society as a whole, especially in security, which, in addition to being considered a necessity for every citizen, is constitutionally guaranteed. This study presents the use of an unsupervised learning approach for the establishment of clusters among the municipalities in the State of Pernambuco, Brazil, considering some types of representative crimes, aiming to direct actions to prevent and fight crime in order to support policy makers. The k-means algorithm was used as the main tool in the study, using the software R 3.6.1, and recommendations for actions were directed to each of the obtained clusters. To demonstrate the direction, the grouping with the parameter k = 26 was used, referring to the State Security Integration Areas. The results show that the use of a clustering approach for the municipalities provides greater effectiveness in directing actions to combat and prevent crime, given that the municipalities that have the greatest similarities are grouped in the same cluster.
DOI: 10.6084/m9.figshare.21624516.v1
title: A CLUSTERING-BASED APPROACH FOR IDENTIFYING GROUPS OF MUNICIPALITIES TO SUPPORT THE DIRECTION OF PUBLIC SECURITY POLICIES

description: ABSTRACT The direction of public policies plays an important role in society as a whole, especially in security, which, in addition to being considered a necessity for every citizen, is constitutionally guaranteed. This study presents the use of an unsupervised learning approach for the establishment of clusters among the municipalities in the State of Pernambuco, Brazil, considering some types of representative crimes, aiming to direct actions to prevent and fight crime in order to support policy makers. The k-means algorithm was used as the main tool in the study, using the software R 3.6.1, and recommendations for actions were directed to each of the obtained clusters. To demonstrate the direction, the grouping with the parameter k = 26 was used, referring to the State Security Integration Areas. The results show that the use of a clustering approach for the municipalities provides greater effectiveness in directing actions to combat and prevent crime, given that the municipalities that have the greatest similarities are grouped in the same cluster.
DOI: 10.6084/m9.figshare.21624517
title: Three Different Strategies for Repair of Symptomatic or Aneurysmatic Aberrant Right Subclavian Arteries

description: ABSTRACT Introduction: In this study, we aimed to present three different methods for symptomatic aberrant right subclavian artery (ARSA) surgery. Methods: We identified 11 consecutive adult patients undergoing symptomatic and/or aneurysmal ARSA repair between January 2016 and December 2020. Symptoms were dysphagia (n=8) and dyspnea + dysphagia (n=3). Six patients had aneurysm formation of the ARSA (mean diameter of 4.2 cm [range 2.8 - 6.3]). All data were analyzed retrospectively. Results: Median age of the patients (7 females/4 males) was 55 years (range 49 - 62). The first four patients (36.4%) underwent hybrid repair using thoracic endovascular aortic repair (TEVAR) and bilateral carotid-subclavian artery bypass (CScBp). Three patients (27.2%) were treated by open ARSA resection/ligation with left mini posterolateral thoracotomy (LMPLT) and right CScBp. And the last four patients (36.4%) underwent ARSA resection/ligation with LMPLT and ascending aorta-right subclavian artery bypass with upper mini sternotomy (UMS). Two of the four patients who underwent TEVAR + bilateral CScBp had continuing dysphagia cause of persistent esophageal compression. Brachial plexus injury developed in one of three patients who underwent LMPLT + right CScBp. Pleural effusion treated with thoracentesis alone was observed in one of four patients who underwent UMS + LMPLT. Conclusion: Among the symptomatic and/or aneurysmal ARSA treatment approaches, surgical and hybrid methods are used. There is still no consensus on how to manage these patients. In our study, we recommend the UMS + LMPLT method, since the risk of complications with anatomical bypass is less, and we have more successful surgical results.