cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.5286/isis.e.rb1920349-1
title: Interaction of an antimicrobial peptide from Lactobacillus gasseri supernatant with lipid bilayers mimicking the bacterial outer membrane

description: A short peptide, composed of 12 amino acids (EFVFVAHAVPVM), presenting a strongly hydrophobic character, was recently isolated from Lactobacillus gasseri supernatant (AMP12). This peptide has shown antimicrobial activity and may also bind the TLR4 receptor or lipopolysaccharides (LPS), which can result in blocking the activation of the inflammatory pathway. AMP12 was also hypothesized to penetrate into the cell given its small size and its character strongly hydrophobic. We are interested in the characterization of the interaction between AMP12 and lipid bilayers as mimics of the bacterial membrane. NR measurements can provide unique information on the mechanism of action of AMP12. We propose to characterize asymmetric lipid bilayers containing LPS from Escherichia Coli to investigate the location of AMP12 with respect to the bilayer.
DOI: 10.5286/isis.e.rb1920448
title: Characterisation of Hybrid Lipid-Polymer Nanoparticles

description: Hybrid lipid-polymer nanoparticles have demonstrated potential as drug delivery vehicles. The current proposal aims to use small angle neutron scattering (SANS) in combination with contrast variation to determine the detailed molecular structure of the drug-containing hybrid lipid-polymer nanoparticles, as well as their component lipid vesicles and polymeric nanoparticles. SANS coupled with contrast variation will allow us to establish precisely how much lipid is required to reproducibly and reliably coat the various sized polymeric NPs without using so much lipid so that excess vesicles are present. The information gained from SANS will be important in optimising the hybrid lipid-polymer formulations.
DOI: 10.5286/isis.e.rb1920448-1
title: Characterisation of Hybrid Lipid-Polymer Nanoparticles

description: Hybrid lipid-polymer nanoparticles have demonstrated potential as drug delivery vehicles. The current proposal aims to use small angle neutron scattering (SANS) in combination with contrast variation to determine the detailed molecular structure of the drug-containing hybrid lipid-polymer nanoparticles, as well as their component lipid vesicles and polymeric nanoparticles. SANS coupled with contrast variation will allow us to establish precisely how much lipid is required to reproducibly and reliably coat the various sized polymeric NPs without using so much lipid so that excess vesicles are present. The information gained from SANS will be important in optimising the hybrid lipid-polymer formulations.
DOI: 10.5286/isis.e.rb1920501
title: Investigating the stability and energetics of the hidden low temperature skyrmion phase in Zn/Ni doped Cu2OSeO3

description: Magnetic skyrmions are topologically protected spin structures with potential uses in low power devices. Cu2OSeO3 is a cubic material containing both skyrmions and other spin textures in a rich magnetic-phase diagram arising from the competition of interactions. Small angle neutron scattering (SANS) has frequently been used to study the skyrmion state and related magnetic spin textures. Recently, a low temperature (LT) skyrmion state and a tilted conical state have been observed in Cu2OSeO3 with fields along the [001] axes, which are suggested to be stabilised by cubic anisotropy. Here we propose to use SANS to study these phases in three samples of Cu2OSeO3: Pristine, nickel and zinc doped. We wish to investigate the effect of doping on the stability of this exciting new skyrmion phase, and to perform micromagnetic simulations to evaluate the proposed stabilisation mechanism.
DOI: 10.5286/isis.e.rb1920501-1
title: Investigating the stability and energetics of the hidden low temperature skyrmion phase in Zn/Ni doped Cu2OSeO3

description: Magnetic skyrmions are topologically protected spin structures with potential uses in low power devices. Cu2OSeO3 is a cubic material containing both skyrmions and other spin textures in a rich magnetic-phase diagram arising from the competition of interactions. Small angle neutron scattering (SANS) has frequently been used to study the skyrmion state and related magnetic spin textures. Recently, a low temperature (LT) skyrmion state and a tilted conical state have been observed in Cu2OSeO3 with fields along the [001] axes, which are suggested to be stabilised by cubic anisotropy. Here we propose to use SANS to study these phases in three samples of Cu2OSeO3: Pristine, nickel and zinc doped. We wish to investigate the effect of doping on the stability of this exciting new skyrmion phase, and to perform micromagnetic simulations to evaluate the proposed stabilisation mechanism.
DOI: 10.34619/9pzn-h470
title: Overexpression of isocitrate lyase-glyoxylate bypass influence on metabolism in Aspergillus niger [Datasets]

description: Data from the manuscript: Meijer S, Otero J, Olivares R, Andersen MR, Olsson L, Nielsen J. Overexpression of isocitrate lyase-glyoxylate bypass influence on metabolism in Aspergillus niger. Metab Eng. 2009;11(2):107-116. doi:10.1016/j.ymben.2008.12.002
DOI: 10.5286/isis.e.rb1910209
title: Photo-catalytic oxidation of phenol over porous TiO2: A Modulation excitation study

description: Solar energy is an abundant renewable source to tackle energy and environmental concerns. For example, solar energy can be converted into electricity, can be used to produce fuels from water and/or CO2 and can be utilised to purify polluted air and water from industrial wastes. These photo-catalytic processes involve a catalyst which plays a crucial role in the efficiency of a process. We study photocatalytic oxidation of organic pollutants, such as phenol, from waste water using a porous TiO2 catalyst. This photo-catalytic process however has low efficiency and produces unwanted by-products which are equally, if not more, harmful than the parent pollutant itself. Therefore, using total neutron scattering, we aim to better understand the local environment of liquids (structure and orientation) within catalyst pores and thereby the reaction mechanism to mitigate unwanted by-products.
DOI: 10.5286/isis.e.rb1910209-1
title: Photo-catalytic oxidation of phenol over porous TiO2: A Modulation excitation study

description: Solar energy is an abundant renewable source to tackle energy and environmental concerns. For example, solar energy can be converted into electricity, can be used to produce fuels from water and/or CO2 and can be utilised to purify polluted air and water from industrial wastes. These photo-catalytic processes involve a catalyst which plays a crucial role in the efficiency of a process. We study photocatalytic oxidation of organic pollutants, such as phenol, from waste water using a porous TiO2 catalyst. This photo-catalytic process however has low efficiency and produces unwanted by-products which are equally, if not more, harmful than the parent pollutant itself. Therefore, using total neutron scattering, we aim to better understand the local environment of liquids (structure and orientation) within catalyst pores and thereby the reaction mechanism to mitigate unwanted by-products.
DOI: 10.5286/isis.e.rb1910457
title: Probing the Structure and Evolution of Anode Materials in Thermal Batteries using In-Situ Diffraction

description: Thermal batteries are primary batteries which find use in applications such as emergency power supplies in aircraft. They are required to provide a constant power over a given length of time. These batteries contain air/mositure sensitive components and operate at high temperature, which has hindered studies to understand how these batteries work. Recent work in our group has probed the structure-property relationships in these batteries by carrying out combined electrochemical and diffraction studies on the Polaris diffractometer. However, several questions remain, all relating to the anode materials. Here we intend to probe the high temperature structure of several anode materials and then look at the structual evolution of the anode during battery discharge.
DOI: 10.5286/isis.e.rb1910457-1
title: Probing the Structure and Evolution of Anode Materials in Thermal Batteries using In-Situ Diffraction

description: Thermal batteries are primary batteries which find use in applications such as emergency power supplies in aircraft. They are required to provide a constant power over a given length of time. These batteries contain air/mositure sensitive components and operate at high temperature, which has hindered studies to understand how these batteries work. Recent work in our group has probed the structure-property relationships in these batteries by carrying out combined electrochemical and diffraction studies on the Polaris diffractometer. However, several questions remain, all relating to the anode materials. Here we intend to probe the high temperature structure of several anode materials and then look at the structual evolution of the anode during battery discharge.
DOI: 10.5286/isis.e.rb1920098
title: Probing the dimensional crossover of critical fluctuations in ferromagnetic quantum critical system UCoSi2

description: In recent times, study of quantum critical point(QCP) and quantum phase transition(QPT) has become one of the most appealing research topics. Notably, near the critical point one observes unconventional power-law type divergence of different physical properties such as electrical resistivity or heat capacity. Such unusual behavior solely depend on the dimensionality of the critical spin fluctuations. We have recently investigated UCoSi2 which is proposed to be situated very close to ferromagnetic (FM) quantum critical point. Interestingly, it exhibits a dimensional crossover of critical fluctuations from 2D-FM to 3D-AFM which has not been experimentally observed before. μSR is an excellent technique to probe such spin fluctuations. Therefore, we propose to carry out μSR measurements on UCoSi2 to verify this dimensional crossover and study the spin dynamics.
DOI: 10.5286/isis.e.rb1920099
title: Solubilisation of membrane protein REAMP in polymer-stabilised nanodiscs

description: Poly(Styrene-Maleic Acid) (SMA) is increasingly used in the formation of lipid-nanodiscs for structural membrane studies and biophysics. These polymer-formed nanodiscs are an appealing choice compared to more traditional alternatives, as preparations are stable, quick, low cost and can be produced in large quantities. In this proposal we wish to study the membrane proteins gramicidin and REAMP within polymer-nanodiscs using SMA variants. REAMP is a de novo membrane protein containing four alpha-helical transmembrane domains while gramicidin is readily available. This study will enable us to evaluate the key contrasts required for membrane protein study when incorporated into nanodiscs and whether REAMP maintains its native formation, ultimately to obtain its 3D structure. This highlights the potential to use polymer-stabilised nanodiscs for membrane protein structural analysis using SANS
DOI: 10.5286/isis.e.rb1920099-1
title: Solubilisation of membrane protein REAMP in polymer-stabilised nanodiscs

description: Poly(Styrene-Maleic Acid) (SMA) is increasingly used in the formation of lipid-nanodiscs for structural membrane studies and biophysics. These polymer-formed nanodiscs are an appealing choice compared to more traditional alternatives, as preparations are stable, quick, low cost and can be produced in large quantities. In this proposal we wish to study the membrane proteins gramicidin and REAMP within polymer-nanodiscs using SMA variants. REAMP is a de novo membrane protein containing four alpha-helical transmembrane domains while gramicidin is readily available. This study will enable us to evaluate the key contrasts required for membrane protein study when incorporated into nanodiscs and whether REAMP maintains its native formation, ultimately to obtain its 3D structure. This highlights the potential to use polymer-stabilised nanodiscs for membrane protein structural analysis using SANS
DOI: 10.5286/isis.e.rb1920264
title: To measure the length scale of magnetic domains across the metal to insulator transition in a Pr, Ca co-doped LaMnO3 thin film using GISANS

description: Pr, Ca co-doped LaMnO3(LPCMO) exhibits a variety of complex physical properties owing to the co-existence and competition of different structural, magnetic and electronic degrees of freedom. The complex interplay of lattice, orbital, spin and charge interactions in LPCMO gives rise to a very rich phase diagram with properties such as a metal to insulator transition (MIT), colossal magneto-resistance and phase separation. In bulk hole-doped manganites, multiple electronic phases coexist as a consequence of non-uniform distributions of strain and magnetic phases on different length scales from nm to micron are reported. using GISANS measurements we will obtain direct evidence of the length scale of magnetic domain and its shape as well as correlations with nonmagnetic domains in these manganite systems, which will help in understanding the phenomena of phase coexistence in these system
DOI: 10.5286/isis.e.rb1920264-1
title: To measure the length scale of magnetic domains across the metal to insulator transition in a Pr, Ca co-doped LaMnO3 thin film using GISANS

description: Pr, Ca co-doped LaMnO3(LPCMO) exhibits a variety of complex physical properties owing to the co-existence and competition of different structural, magnetic and electronic degrees of freedom. The complex interplay of lattice, orbital, spin and charge interactions in LPCMO gives rise to a very rich phase diagram with properties such as a metal to insulator transition (MIT), colossal magneto-resistance and phase separation. In bulk hole-doped manganites, multiple electronic phases coexist as a consequence of non-uniform distributions of strain and magnetic phases on different length scales from nm to micron are reported. using GISANS measurements we will obtain direct evidence of the length scale of magnetic domain and its shape as well as correlations with nonmagnetic domains in these manganite systems, which will help in understanding the phenomena of phase coexistence in these system
DOI: 10.5281/zenodo.3571430
title: Traits-climate range limits data and code (Van Nuland et al. 2019; Ecology and Evolution)

description: Data and code associated with Van Nuland et al. manuscript “<em>Intraspecific trait variation across elevation predicts a widespread tree species’ climate niche and range limits</em>” in Ecology and Evolution.
DOI: 10.5281/zenodo.3571431
title: Traits-climate range limits data and code (Van Nuland et al. 2019; Ecology and Evolution)

description: Data and code associated with Van Nuland et al. manuscript “<em>Intraspecific trait variation across elevation predicts a widespread tree species’ climate niche and range limits</em>” in Ecology and Evolution.
DOI: 10.5286/isis.e.rb1910291
title: Evolution of serpentinite oceanic textures across Alpine metamorphism: neutron radiography and computed tomography

description: Serpentinisation of oceanic mantle is one of the most important mineralogical reactions in the Earth Science. This reaction involves the interaction between the upper mantle mineral with seawater at temperatures ranging from 100 to 350oC and produces a magnesium-rich hydrous silicate, serpentine ((Mg,Fe)3Si2O5(OH)4). Once subducted the seperntinised oceanic lithosphere is believed to play a major role in supplying water to the overlying mantle wedge and may trigger intermediate earthquakes. Recovered serpentinised rocks are useful in understanding the high-pressure and high-temperature behaviour of the serpentines encountered in subducted slabs and show textures that are partly preserved from the oceanic process. It is the aim of this study to use neutron tomography to obtain the three-dimensional distribution of the hydrous phases in serpentines recovered form the Western Alps.
DOI: 10.5286/isis.e.rb1910291-1
title: Evolution of serpentinite oceanic textures across Alpine metamorphism: neutron radiography and computed tomography

description: Serpentinisation of oceanic mantle is one of the most important mineralogical reactions in the Earth Science. This reaction involves the interaction between the upper mantle mineral with seawater at temperatures ranging from 100 to 350oC and produces a magnesium-rich hydrous silicate, serpentine ((Mg,Fe)3Si2O5(OH)4). Once subducted the seperntinised oceanic lithosphere is believed to play a major role in supplying water to the overlying mantle wedge and may trigger intermediate earthquakes. Recovered serpentinised rocks are useful in understanding the high-pressure and high-temperature behaviour of the serpentines encountered in subducted slabs and show textures that are partly preserved from the oceanic process. It is the aim of this study to use neutron tomography to obtain the three-dimensional distribution of the hydrous phases in serpentines recovered form the Western Alps.
DOI: 10.5286/isis.e.rb1920098-1
title: Probing the dimensional crossover of critical fluctuations in ferromagnetic quantum critical system UCoSi2

description: In recent times, study of quantum critical point(QCP) and quantum phase transition(QPT) has become one of the most appealing research topics. Notably, near the critical point one observes unconventional power-law type divergence of different physical properties such as electrical resistivity or heat capacity. Such unusual behavior solely depend on the dimensionality of the critical spin fluctuations. We have recently investigated UCoSi2 which is proposed to be situated very close to ferromagnetic (FM) quantum critical point. Interestingly, it exhibits a dimensional crossover of critical fluctuations from 2D-FM to 3D-AFM which has not been experimentally observed before. μSR is an excellent technique to probe such spin fluctuations. Therefore, we propose to carry out μSR measurements on UCoSi2 to verify this dimensional crossover and study the spin dynamics.
DOI: 10.5286/isis.e.rb1920355
title: Structure of responsive PNIPAM-PAAc microgels

description: We propose to investigate a temperature and pH responsive microgel composed of Interpenetrating Polymer Networks (IPN) of poly(N-isopropylacrylamide) (PNIPAM) and poly(acrylic) acid (PAAc). The dynamical and structural behaviour of both PNIPAM and IPN microgels as a function of temperature, concentration, pH and acrylic acid content has been widely investigated by our group by combining DLS, SANS, SAXS, XPCS, Raman spectroscopy, TEM and electrophoretic measurements.In this experiment we want to perform SANS measurements with a contrast-matched deuterated PNIPAM to follow changes in the PAAc conformational distribution within the PNIPAM network. At the same time, we will explore how these structural changes affect the gel dynamics by performing simultaneous DLS measurements using apparatus newly-developed as part of a joint CNR-ISIS project.
DOI: 10.5286/isis.e.rb1920355-1
title: Structure of responsive PNIPAM-PAAc microgels

description: We propose to investigate a temperature and pH responsive microgel composed of Interpenetrating Polymer Networks (IPN) of poly(N-isopropylacrylamide) (PNIPAM) and poly(acrylic) acid (PAAc). The dynamical and structural behaviour of both PNIPAM and IPN microgels as a function of temperature, concentration, pH and acrylic acid content has been widely investigated by our group by combining DLS, SANS, SAXS, XPCS, Raman spectroscopy, TEM and electrophoretic measurements.In this experiment we want to perform SANS measurements with a contrast-matched deuterated PNIPAM to follow changes in the PAAc conformational distribution within the PNIPAM network. At the same time, we will explore how these structural changes affect the gel dynamics by performing simultaneous DLS measurements using apparatus newly-developed as part of a joint CNR-ISIS project.
DOI: 10.5286/isis.e.rb1920721
title: Isotope analysis of materials using muonic X-ray and gammas

description: Isotope composition can be affected by natural phenomena and human activity. These effects can provide information on the origin of the material. The most commonly known isotope analysis tool is carbon dating. However, a range of isotopes can be used within cultural heritage and archaeology (H, B, C, N, O, Mg, Si, S, Cl, Ar, Ca, Fe, Cu, Zn, Sr, Ag, Sn, Nd, Hg, Pb, Th, U) for dating, provenance, diet of humans, migration among humans and even ore prospecting pollution [1]. Isotope analysis is not only restricted to cultural heritage, it can be applied to many other areas, such as: forensics, food and beverage industry, environmental sciences, history, heritage science, and also utilised to detect forgeries in art. During the muon capture process a gamma is released and is characteristic of the isotope. If this project is successful, it will enable much greater information to be extracted.
DOI: 10.5286/isis.e.rb1920721-1
title: Isotope analysis of materials using muonic X-ray and gammas

description: Isotope composition can be affected by natural phenomena and human activity. These effects can provide information on the origin of the material. The most commonly known isotope analysis tool is carbon dating. However, a range of isotopes can be used within cultural heritage and archaeology (H, B, C, N, O, Mg, Si, S, Cl, Ar, Ca, Fe, Cu, Zn, Sr, Ag, Sn, Nd, Hg, Pb, Th, U) for dating, provenance, diet of humans, migration among humans and even ore prospecting pollution [1]. Isotope analysis is not only restricted to cultural heritage, it can be applied to many other areas, such as: forensics, food and beverage industry, environmental sciences, history, heritage science, and also utilised to detect forgeries in art. During the muon capture process a gamma is released and is characteristic of the isotope. If this project is successful, it will enable much greater information to be extracted.
DOI: 10.5286/isis.e.rb1920721-2
title: Isotope analysis of materials using muonic X-ray and gammas

description: Isotope composition can be affected by natural phenomena and human activity. These effects can provide information on the origin of the material. The most commonly known isotope analysis tool is carbon dating. However, a range of isotopes can be used within cultural heritage and archaeology (H, B, C, N, O, Mg, Si, S, Cl, Ar, Ca, Fe, Cu, Zn, Sr, Ag, Sn, Nd, Hg, Pb, Th, U) for dating, provenance, diet of humans, migration among humans and even ore prospecting pollution [1]. Isotope analysis is not only restricted to cultural heritage, it can be applied to many other areas, such as: forensics, food and beverage industry, environmental sciences, history, heritage science, and also utilised to detect forgeries in art. During the muon capture process a gamma is released and is characteristic of the isotope. If this project is successful, it will enable much greater information to be extracted.
DOI: 10.5286/isis.e.rb1920746
title: Quantification of water distribution in chalk/pile interface after pile installation

description: Carbon emissions, from electricity generation, is a significant contributor to global warming. With wind power maturing as a sustainable source of clean energy, wind farms are increasingly moving offshore to take advantage of higher wind speeds. However, a lack of understanding of how pile foundations in saturated chalk resist loading has led to industry-wide over-conservative safety factors. As a result, costs have increased by 50%. In this proposal, we intend to make use of IMAT to perform Neutron Computed Tomography on a physical simulation of pile installation in chalk. We expect to quantify and compare the difference of water content in the crushed chalk at the interface of the pile and the undisturbed chalk far away from the pile.