cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.20317254
title: Fast acquisition of left and right ventricular function parameters applying cardiovascular magnetic resonance in clinical routine – validation of a 2-shot compressed sensing cine sequence

description: <i>Objectives.</i> To evaluate if cine sequences accelerated by compressed sensing (CS) are feasible in clinical routine and yield equivalent cardiac morphology in less time. <i>Design.</i> We evaluated 155 consecutive patients with various cardiac diseases scanned during our clinical routine. LV and RV short axis (SAX) cine images were acquired by conventional and prototype 2-shot CS sequences on a 1.5 T CMR. The 2-shot prototype captures the entire heart over a period of 3 beats making the acquisition potentially even faster. Both scans were performed with identical slice parameters and positions. We compared LV and RV morphology with Bland-Altmann plots and weighted the results in relation to pre-defined tolerance intervals. Subjective and objective image quality was evaluated using a 4-point score and adapted standardized criteria. Scan times were evaluated for each sequence. <i>Results.</i> In total, no acquisitions were lost due to non-diagnostic image quality in the subjective image score. Objective image quality analysis showed no statistically significant differences. The scan time of the CS cines was significantly shorter (<i>p</i> &lt; .001) with mean scan times of 178 ± 36 s compared to 313 ± 65 s for the conventional cine. All cardiac function parameters showed excellent correlation (<i>r</i> 0.978–0.996). Both sequences were considered equivalent for the assessment of LV and RV morphology. <i>Conclusions.</i> The 2-shot CS SAX cines can be used in clinical routine to acquire cardiac morphology in less time compared to the conventional method, with no total loss of acquisitions due to nondiagnostic quality. ISRCTN12344380. Registered 20 November 2020, retrospectively registered.
DOI: 10.6084/m9.figshare.20622045
title: Epicardial transplantation of autologous atrial appendage micrografts: evaluation of safety and feasibility in pigs after coronary artery occlusion

description: <i>Objectives.</i> Several approaches devised for clinical utilization of cell-based therapies for heart failure often suffer from complex and lengthy preparation stages. Epicardial delivery of autologous atrial appendage micrografts (AAMs) with a clinically used extracellular matrix (ECM) patch provides a straightforward therapy alternative. We evaluated the operative feasibility and the effect of micrografts on the patch-induced epicardial foreign body inflammatory response in a porcine model of myocardial infarction. <i>Design.</i> Right atrial appendages were harvested and mechanically processed into AAMs. The left anterior descending coronary artery was ligated to generate acute infarction. Patches of ECM matrix with or without AAMs were transplanted epicardially onto the infarcted area. Four pigs received the ECM and four received the AAMs patch. Cardiac function was studied by echocardiography both preoperatively and at 3-week follow-up. The primary outcome measures were safety and feasibility of the therapy administration, and the secondary outcome was the inflammatory response to ECM. <i>Results.</i> Neither AAMs nor ECM patch-related complications were detected during the follow-up time. AAMs patch preparation was feasible according to time and safety. Inflammation was greatly reduced in AAMs when compared with ECM patches as measured by the amount of infiltrated inflammatory cells and area of inflammation. Immunohistochemistry demonstrated an increased CD3+ cell density in the AAMs patch infiltrate. <i>Conclusions.</i> Epicardial AAMs transplantation demonstrated safety and clinical feasibility. The use of micrografts significantly inhibited ECM-induced foreign body inflammatory reactivity. Transplantation of AAMs shows good clinical applicability as adjuvant therapy to cardiac surgery and can suppress acute inflammatory reactivity.
DOI: 10.6084/m9.figshare.20622045.v1
title: Epicardial transplantation of autologous atrial appendage micrografts: evaluation of safety and feasibility in pigs after coronary artery occlusion

description: <i>Objectives.</i> Several approaches devised for clinical utilization of cell-based therapies for heart failure often suffer from complex and lengthy preparation stages. Epicardial delivery of autologous atrial appendage micrografts (AAMs) with a clinically used extracellular matrix (ECM) patch provides a straightforward therapy alternative. We evaluated the operative feasibility and the effect of micrografts on the patch-induced epicardial foreign body inflammatory response in a porcine model of myocardial infarction. <i>Design.</i> Right atrial appendages were harvested and mechanically processed into AAMs. The left anterior descending coronary artery was ligated to generate acute infarction. Patches of ECM matrix with or without AAMs were transplanted epicardially onto the infarcted area. Four pigs received the ECM and four received the AAMs patch. Cardiac function was studied by echocardiography both preoperatively and at 3-week follow-up. The primary outcome measures were safety and feasibility of the therapy administration, and the secondary outcome was the inflammatory response to ECM. <i>Results.</i> Neither AAMs nor ECM patch-related complications were detected during the follow-up time. AAMs patch preparation was feasible according to time and safety. Inflammation was greatly reduced in AAMs when compared with ECM patches as measured by the amount of infiltrated inflammatory cells and area of inflammation. Immunohistochemistry demonstrated an increased CD3+ cell density in the AAMs patch infiltrate. <i>Conclusions.</i> Epicardial AAMs transplantation demonstrated safety and clinical feasibility. The use of micrografts significantly inhibited ECM-induced foreign body inflammatory reactivity. Transplantation of AAMs shows good clinical applicability as adjuvant therapy to cardiac surgery and can suppress acute inflammatory reactivity.
DOI: 10.6084/m9.figshare.20227489
title: Holistic review and meta-analysis of independent impact of the residual SYNTAX score on prognosis in patients with acute coronary syndrome

description: <i>Objectives</i>. The appropriate extent of revascularization following primary intervention is unknown. We conducted a systematic review and meta-analysis of residual Syntax score (rSS) to predict the outcomes and provide guide to optimal management of revascularization following primary intervention. <i>Designs</i>. Previously published studies from 2007 to 2020 assessing the prognostic impact of rSS after ACS were included for this meta-analysis. The primary endpoint was defined as the major adverse clinical events (MACE) in multivariable analysis. The risk ratios (RRs) with 95% confidence intervals (CI) were calculated using the RevMan 5.4 software. <i>Results</i>. A total of 8,157 participants complicated with ACS from 12 clinical studies were included in this analysis. Based on the wide range of rSS studies available, we classified it into two major groups: rSS &lt; 8 and rSS ≥ 8. In multivariate analysis, the rSS was an independent risk marker for MACE [RR = 1.04 (95%CI; 1.00–1.08)], all-cause mortality [RR = 1.05 (1.03–1.07)] and cardiovascular death [RR = 1.05 (1.03–1.07)]. Patients with incomplete revascularization (ICR) showed higher prevalence of MACE along with all-cause mortality, cardiovascular morality, and recurrent myocardial infarction without significant heterogeneity [RR = 1.60 (1.03–1.07), 2.30 (1.57–3.38), 3.57 (2.09–6.10) and 1.70 (1.38–2.09), respectively]. The patients with rSS ≥ 8 presented higher frequency of all-cause mortality [RR = 2.99 (2.18–4.09)], cardiovascular death [RR = 3.32 (2.22–4.95)], and recurrent myocardial infarction [RR = 1.64 (1.34–2.02)]. <i>Conclusion</i>. The meta-analysis indicated that an rSS value of 8 could be a reasonable cut-off for incomplete revascularization after ACS and is an efficient tool to guide revascularization. In future, detailed research should focus on investigation of the optimal value of the rSS score.
DOI: 10.6084/m9.figshare.20227489.v1
title: Holistic review and meta-analysis of independent impact of the residual SYNTAX score on prognosis in patients with acute coronary syndrome

description: <i>Objectives</i>. The appropriate extent of revascularization following primary intervention is unknown. We conducted a systematic review and meta-analysis of residual Syntax score (rSS) to predict the outcomes and provide guide to optimal management of revascularization following primary intervention. <i>Designs</i>. Previously published studies from 2007 to 2020 assessing the prognostic impact of rSS after ACS were included for this meta-analysis. The primary endpoint was defined as the major adverse clinical events (MACE) in multivariable analysis. The risk ratios (RRs) with 95% confidence intervals (CI) were calculated using the RevMan 5.4 software. <i>Results</i>. A total of 8,157 participants complicated with ACS from 12 clinical studies were included in this analysis. Based on the wide range of rSS studies available, we classified it into two major groups: rSS &lt; 8 and rSS ≥ 8. In multivariate analysis, the rSS was an independent risk marker for MACE [RR = 1.04 (95%CI; 1.00–1.08)], all-cause mortality [RR = 1.05 (1.03–1.07)] and cardiovascular death [RR = 1.05 (1.03–1.07)]. Patients with incomplete revascularization (ICR) showed higher prevalence of MACE along with all-cause mortality, cardiovascular morality, and recurrent myocardial infarction without significant heterogeneity [RR = 1.60 (1.03–1.07), 2.30 (1.57–3.38), 3.57 (2.09–6.10) and 1.70 (1.38–2.09), respectively]. The patients with rSS ≥ 8 presented higher frequency of all-cause mortality [RR = 2.99 (2.18–4.09)], cardiovascular death [RR = 3.32 (2.22–4.95)], and recurrent myocardial infarction [RR = 1.64 (1.34–2.02)]. <i>Conclusion</i>. The meta-analysis indicated that an rSS value of 8 could be a reasonable cut-off for incomplete revascularization after ACS and is an efficient tool to guide revascularization. In future, detailed research should focus on investigation of the optimal value of the rSS score.
DOI: 10.6084/m9.figshare.19537353
title: Cost-effectiveness of screening for atrial fibrillation in a single primary care center at a 3-year follow-up

description: The aim of this study was to estimate the cost-effectiveness of intermittent electrocardiogram (ECG) screening for atrial fibrillation (AF) among 70–74-year old individuals in primary care. We also aimed to assess adherence to anticoagulants, severe bleeding, stroke and mortality among screening-detected AF cases at three-year follow-up. A post hoc analysis based on a cross-sectional screening study for AF among 70–74-year old patients, who were registered at a single primary care center, was followed for three years for mortality. Data about adherence to anticoagulants, incidence of stroke and severe bleeding among screening-detected AF cases, were collected from patient’s records. Markov model and Monte Carlo simulation were used to assess the cost-effectiveness of the screening program. The mortality rate among screening-detected AF cases (<i>n</i> = 16) did not differ compared to the 274 individuals with no AF (hazard ratio 0.86, CI 0.12–6.44). Adherence to anticoagulants was 92%. There was no stroke or severe bleeding. The incremental cost-effectiveness ratio of screening versus no screening was EUR 2389/quality-adjusted life year (QALY) gained. The screening showed a 99% probability of being cost-effective compared to no screening at a willingness-to-pay threshold of EUR 20,000 per QALY. Screening for AF among 70–74-year olds in primary care using intermittent ECG appears to be cost-effective at 3-year follow-up with high anticoagulants adherence and no increased mortality.
DOI: 10.6084/m9.figshare.20317254.v1
title: Fast acquisition of left and right ventricular function parameters applying cardiovascular magnetic resonance in clinical routine – validation of a 2-shot compressed sensing cine sequence

description: <i>Objectives.</i> To evaluate if cine sequences accelerated by compressed sensing (CS) are feasible in clinical routine and yield equivalent cardiac morphology in less time. <i>Design.</i> We evaluated 155 consecutive patients with various cardiac diseases scanned during our clinical routine. LV and RV short axis (SAX) cine images were acquired by conventional and prototype 2-shot CS sequences on a 1.5 T CMR. The 2-shot prototype captures the entire heart over a period of 3 beats making the acquisition potentially even faster. Both scans were performed with identical slice parameters and positions. We compared LV and RV morphology with Bland-Altmann plots and weighted the results in relation to pre-defined tolerance intervals. Subjective and objective image quality was evaluated using a 4-point score and adapted standardized criteria. Scan times were evaluated for each sequence. <i>Results.</i> In total, no acquisitions were lost due to non-diagnostic image quality in the subjective image score. Objective image quality analysis showed no statistically significant differences. The scan time of the CS cines was significantly shorter (<i>p</i> &lt; .001) with mean scan times of 178 ± 36 s compared to 313 ± 65 s for the conventional cine. All cardiac function parameters showed excellent correlation (<i>r</i> 0.978–0.996). Both sequences were considered equivalent for the assessment of LV and RV morphology. <i>Conclusions.</i> The 2-shot CS SAX cines can be used in clinical routine to acquire cardiac morphology in less time compared to the conventional method, with no total loss of acquisitions due to nondiagnostic quality. ISRCTN12344380. Registered 20 November 2020, retrospectively registered.
DOI: 10.6084/m9.figshare.19803338
title: Exercise-induced change in circulating NT-proBNP could not distinguish between patients with and without coronary artery disease: the CADENCE study

description: <i>Objective.</i> In patients with chest pain, exercise stress test has a moderate accuracy for coronary artery disease (CAD). Adding a reliable cardiac biomarker to the exercise test could potentially improve the precision of the test. We investigated circulating NT-proBNP levels before and during exercise stress test in patients with and without angiographically verified CAD. We hypothesized that NT-proBNP would give an additive diagnostic value to the exercise stress test. <i>Methods</i>. In patients presenting with symptoms of stable CAD, venous blood samples were taken at rest and within 5 min of termination of a maximal stress test on a bicycle ergometer. All study participants underwent coronary angiography. Significant CAD was defined as ≥75% stenosis in one or more segments of the coronary arteries. <i>Results</i>. Of the 297 participants, significant CAD was found in 111 (37%) patients. Resting levels of NT-proBNP were significantly higher in patients with CAD compared with patients without CAD (74.18 vs. 56.03 ng/L), <i>p</i> = .005. During exercise, NT-proBNP levels increased in the total population (<i>p</i> &lt; .001). The rise was, however, not significantly different between the two groups (8.24 vs. 8.51 ng/L), <i>p</i> = .700. Combining resting NT-proBNP with positive exercise stress test was superior to exercise test alone in predicting CAD, AUC = 0.68 vs. 0.64. <i>Conclusion</i>. Exercise-induced change in circulating NT-proBNP could not distinguish between patients with or without CAD. However, resting levels of NT-proBNP were significantly higher in patients with CAD than those without CAD.
DOI: 10.6084/m9.figshare.19803338.v1
title: Exercise-induced change in circulating NT-proBNP could not distinguish between patients with and without coronary artery disease: the CADENCE study

description: <i>Objective.</i> In patients with chest pain, exercise stress test has a moderate accuracy for coronary artery disease (CAD). Adding a reliable cardiac biomarker to the exercise test could potentially improve the precision of the test. We investigated circulating NT-proBNP levels before and during exercise stress test in patients with and without angiographically verified CAD. We hypothesized that NT-proBNP would give an additive diagnostic value to the exercise stress test. <i>Methods</i>. In patients presenting with symptoms of stable CAD, venous blood samples were taken at rest and within 5 min of termination of a maximal stress test on a bicycle ergometer. All study participants underwent coronary angiography. Significant CAD was defined as ≥75% stenosis in one or more segments of the coronary arteries. <i>Results</i>. Of the 297 participants, significant CAD was found in 111 (37%) patients. Resting levels of NT-proBNP were significantly higher in patients with CAD compared with patients without CAD (74.18 vs. 56.03 ng/L), <i>p</i> = .005. During exercise, NT-proBNP levels increased in the total population (<i>p</i> &lt; .001). The rise was, however, not significantly different between the two groups (8.24 vs. 8.51 ng/L), <i>p</i> = .700. Combining resting NT-proBNP with positive exercise stress test was superior to exercise test alone in predicting CAD, AUC = 0.68 vs. 0.64. <i>Conclusion</i>. Exercise-induced change in circulating NT-proBNP could not distinguish between patients with or without CAD. However, resting levels of NT-proBNP were significantly higher in patients with CAD than those without CAD.
DOI: 10.6084/m9.figshare.19537353.v1
title: Cost-effectiveness of screening for atrial fibrillation in a single primary care center at a 3-year follow-up

description: The aim of this study was to estimate the cost-effectiveness of intermittent electrocardiogram (ECG) screening for atrial fibrillation (AF) among 70–74-year old individuals in primary care. We also aimed to assess adherence to anticoagulants, severe bleeding, stroke and mortality among screening-detected AF cases at three-year follow-up. A post hoc analysis based on a cross-sectional screening study for AF among 70–74-year old patients, who were registered at a single primary care center, was followed for three years for mortality. Data about adherence to anticoagulants, incidence of stroke and severe bleeding among screening-detected AF cases, were collected from patient’s records. Markov model and Monte Carlo simulation were used to assess the cost-effectiveness of the screening program. The mortality rate among screening-detected AF cases (<i>n</i> = 16) did not differ compared to the 274 individuals with no AF (hazard ratio 0.86, CI 0.12–6.44). Adherence to anticoagulants was 92%. There was no stroke or severe bleeding. The incremental cost-effectiveness ratio of screening versus no screening was EUR 2389/quality-adjusted life year (QALY) gained. The screening showed a 99% probability of being cost-effective compared to no screening at a willingness-to-pay threshold of EUR 20,000 per QALY. Screening for AF among 70–74-year olds in primary care using intermittent ECG appears to be cost-effective at 3-year follow-up with high anticoagulants adherence and no increased mortality.
DOI: 10.15468/dl.nmhp3w
title: Occurrence Download

description: A dataset containing 14725 species occurrences available in GBIF matching the query:
{
 "and" : [
 "OccurrenceStatus is Present",
 "TaxonKey is Macaca cyclopis (Swinhoe, 1863)"
 ]
}

 The dataset includes 14725 records from 33 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0017398-240906103802322/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.3886/e192306v4-156741
title: GEOWEALTH-US: Spatial wealth inequality data for the United States, 1960-2020

description: Wealth inequality has been sharply rising in the United States and across many other high-income countries. Due to a lack of data, we know little about how this trend has unfolded across locations within countries. Investigating this subnational geography of wealth is crucial, as from one generation to the next, wealth powerfully shapes opportunity and disadvantage across individuals and communities. Using machine-learning-based imputation to link newly assembled national historical surveys conducted by the U.S. Federal Reserve to population survey microdata, the data presented in this paper addresses this gap. The Geographic Wealth Inequality Database ("GEOWEALTH-US") provides the first estimates of the level and distribution of wealth at various geographical scales within the United States from 1960 to 2020. The GEOWEALTH-US database enables new lines investigation into the contribution of inter-regional wealth patterns to major societal challenges including wealth concentration, spatial income inequality, equality of opportunity, housing unaffordability, and political polarization.<br>
DOI: 10.6084/m9.figshare.27024652
title: Code: Demographic effects of sanitary policies on European vulture population dynamics: a retrospective modelling approachled Item

description: he prediction of population responses to environmental changes, including the effects of different management scenarios, is a useful tool and a necessary contributor to improving conservation decisions. Empirical datasets based on long-term monitoring studies are essential to assess the robustness of retrospective modelling predictions on biodiversity. These allow checks on the performance of modelling projections and enable improvements to be made to future models, based on the errors detected. Here, we assess the performance of our earlier model to assess the impact of vulture food shortages caused by sanitary regulations on the population dynamics of Spanish vultures during the past decade (2009–2019). This model forecasts the population trends of three vulture species (griffon, Egyptian and bearded vultures) in Spain (home to 90% of the European vulture population) under various food shortage scenarios. We show that it underestimated bearded and griffon vulture population numbers and overestimated Egyptian vultures. The model suggested that the most plausible food shortage scenario involved an approximate 50% reduction of livestock carcass availability in the ecosystem compared with the previous situation without sanitary carcass removal. However, the observed annual population growth for the period 2009–2019 (7.8% for griffon vulture, 2.4% for Egyptian vulture and 3.5% for bearded vulture) showed that food shortages had little impact on vulture population dynamics. After assessing the robustness of the model, we developed a new model with updated demographic parameters and foraging movements under different hypothetical food shortage scenarios for the period 2019–2029. This model forecasts annual population increases of about 3.6% for the bearded vulture, 3.7% for the Egyptian vulture, and 1.1% for the Griffon vulture. Our findings suggest that food shortages due to the implementation of sanitary policies resulted in only a moderate impact on vulture population growth, probably thanks to the supplementary feeding network which provided alternative food. Also important was the availability of alternative food sources (intensive farms, landfills) that were used more regularly than expected. We discuss the computational performance of our modelling approach and its management consequences to improve future conservation measures for these threatened species, which provide essential ecosystem services.