cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.23300514
title: Simultaneous posterior eyelid ptosis repair and strabismus surgery: a single-stage approach

description: ABSTRACT Purpose: Blepharoptosis with coexisting strabismus can be observed in adults, and both these conditions affect cosmetic appearance and have psychosocial effects. Both also commonly require surgery, which is typically performed using a sequential approach. This study aimed to evaluate the efficacy of simultaneous Müller’s muscle-conjunctival resection with or without tarsectomy and strabismus surgery in adult patients with ptosis and coexisting strabismus. Methods: Patients with ptosis and coexisting strabismus who underwent simultaneous Müller’s muscle-conjunctival resection with or without tarsectomy and horizontal strabismus surgery were retrospectively evaluated. Analysis included measurement of the angle of deviation in prism diopters, margin reflex distance, eyelid height asymmetry, and complications following surgery. Success of Müller’s muscle-conjunctival resection with or without tarsectomy was defined as a margin reflex distance of ≥3.5 and ≤5 mm with a difference between the two upper eyelids of &lt;1 mm. Strabismus success was defined as alignment with ±10 prism diopters of orthotropia. Results: The patients comprised three women and five men with a mean age of 37.12 years (range, 22-62 years). The strabismus stage of the surgery was performed first in all patients. Upper eyelid symmetry outcomes were assessed as perfect (&lt;0.5 mm) in four patients and good (≥0.5 mm, &lt;1 mm) in four patients. Success of Müller’s muscle-conjunctival resection with or without tarsectomy was achieved in six of eight patients (75%), and strabismus success was achieved in all patients. No revision eyelid or strabismus surgery was required following simultaneous surgery in any of the patients. Conclusion: Müller’s muscle-conjunctival resection with or without tarsectomy combined with strabismus surgery may be an alternative approach for use in patients with ptosis and coexisting strabismus.
DOI: 10.6084/m9.figshare.23300514.v1
title: Simultaneous posterior eyelid ptosis repair and strabismus surgery: a single-stage approach

description: ABSTRACT Purpose: Blepharoptosis with coexisting strabismus can be observed in adults, and both these conditions affect cosmetic appearance and have psychosocial effects. Both also commonly require surgery, which is typically performed using a sequential approach. This study aimed to evaluate the efficacy of simultaneous Müller’s muscle-conjunctival resection with or without tarsectomy and strabismus surgery in adult patients with ptosis and coexisting strabismus. Methods: Patients with ptosis and coexisting strabismus who underwent simultaneous Müller’s muscle-conjunctival resection with or without tarsectomy and horizontal strabismus surgery were retrospectively evaluated. Analysis included measurement of the angle of deviation in prism diopters, margin reflex distance, eyelid height asymmetry, and complications following surgery. Success of Müller’s muscle-conjunctival resection with or without tarsectomy was defined as a margin reflex distance of ≥3.5 and ≤5 mm with a difference between the two upper eyelids of &lt;1 mm. Strabismus success was defined as alignment with ±10 prism diopters of orthotropia. Results: The patients comprised three women and five men with a mean age of 37.12 years (range, 22-62 years). The strabismus stage of the surgery was performed first in all patients. Upper eyelid symmetry outcomes were assessed as perfect (&lt;0.5 mm) in four patients and good (≥0.5 mm, &lt;1 mm) in four patients. Success of Müller’s muscle-conjunctival resection with or without tarsectomy was achieved in six of eight patients (75%), and strabismus success was achieved in all patients. No revision eyelid or strabismus surgery was required following simultaneous surgery in any of the patients. Conclusion: Müller’s muscle-conjunctival resection with or without tarsectomy combined with strabismus surgery may be an alternative approach for use in patients with ptosis and coexisting strabismus.
DOI: 10.6084/m9.figshare.23300516
title: Prospective evaluation of the effectiveness of combined treatment of macular edema secondary to retinal vein occlusion with intravitreal bevacizumab and dexamethasone implants

description: ABSTRACT Purpose: To evaluate the effectiveness of intravitreal bevacizumab injections following a single dexamethasone implant in the treatment of macular edema secondary to branch and central retinal vein occlusion. Methods: This was a prospective interventional non-comparative study, 44 eyes of patients with naïve macular edema related to branch and central retinal vein occlusion were treated with a dexamethasone implant. Patients were followed-up at four-week intervals from the second to the sixth month. If persistent or recurrent macular edema occurred during this period, the patient was treated with intravitreal bevacizumab injections on an as-needed basis. The outcome measures were best-corrected visual acuity and central macular thickness changes. Results: The mean best-corrected visual acuity changed from 0.97 ± 0.33 LogMAR at baseline to 0.54 ± 0.40 at the six-month post-implant examination (p&lt;0.00001). Improvement ≥3 Snellen lines were seen in 20 eyes (45.54%). The mean central macular thickness at baseline was 670.25 ± 209.9 microns. This had decreased to 317.43 ± 112.68 microns at the six-month follow-up (p&lt;0.00001). The mean number of intravitreal bevacizumab injections received in the six months post-implant was 2.32. The mean time from dexamethasone implant to first anti-VEGF injection was 3.45 months. Conclusions: Intravitreal bevacizumab injections following a single dexamethasone implant were found to improve best-corrected visual acuity and central macular thickness in patients with macular edema due to branch and central retinal vein occlusion at six months, with few intravitreal injections required.
DOI: 10.6084/m9.figshare.23300516.v1
title: Prospective evaluation of the effectiveness of combined treatment of macular edema secondary to retinal vein occlusion with intravitreal bevacizumab and dexamethasone implants

description: ABSTRACT Purpose: To evaluate the effectiveness of intravitreal bevacizumab injections following a single dexamethasone implant in the treatment of macular edema secondary to branch and central retinal vein occlusion. Methods: This was a prospective interventional non-comparative study, 44 eyes of patients with naïve macular edema related to branch and central retinal vein occlusion were treated with a dexamethasone implant. Patients were followed-up at four-week intervals from the second to the sixth month. If persistent or recurrent macular edema occurred during this period, the patient was treated with intravitreal bevacizumab injections on an as-needed basis. The outcome measures were best-corrected visual acuity and central macular thickness changes. Results: The mean best-corrected visual acuity changed from 0.97 ± 0.33 LogMAR at baseline to 0.54 ± 0.40 at the six-month post-implant examination (p&lt;0.00001). Improvement ≥3 Snellen lines were seen in 20 eyes (45.54%). The mean central macular thickness at baseline was 670.25 ± 209.9 microns. This had decreased to 317.43 ± 112.68 microns at the six-month follow-up (p&lt;0.00001). The mean number of intravitreal bevacizumab injections received in the six months post-implant was 2.32. The mean time from dexamethasone implant to first anti-VEGF injection was 3.45 months. Conclusions: Intravitreal bevacizumab injections following a single dexamethasone implant were found to improve best-corrected visual acuity and central macular thickness in patients with macular edema due to branch and central retinal vein occlusion at six months, with few intravitreal injections required.
DOI: 10.6084/m9.figshare.23300517
title: Comparison of the short-term results of nasal and temporal 180° selective laser trabeculoplasties for open-angle glaucoma

description: ABSTRACT Purpose: The nasal sector of the anterior chamber angle may present a higher density of collector channels, which may influence the results of angle surgeries. Considering the anatomical differences in the anterior chamber angle, we compared the results of the nasal and temporal 180° selective laser trabeculoplasty approaches for open-angle glaucoma. Methods: A retrospective chart review was conducted for patients with open-angle glaucoma (primary, pseudoexfoliation, and pigmentary) who underwent at least one 180° selective laser trabeculoplasty session between December 2016 and October 2018. The nasal (N1) or temporal (T1) sectors were chosen at the physician’s discretion. Patients who did not experience decreased intraocular pressure between 3 and 6 months again underwent 180° selective laser trabeculoplasty in the opposite angle sector (T2 and N2). The main outcome measured was decrease in intraocular pressure at 6-month follow-up, after the last selective laser trabeculoplasty. A multivariable regression analysis was used to evaluate factors associated with decreased intraocular pressure after treatment. Results: The procedure was performed initially in 45 eyes (N1, 25; T1, 20 eyes) and repeated in the opposite anterior chamber angle sector in 19 eyes (N2, 11; T2, 8 eyes). Analysis of variance revealed that only the N1 approach presented a significant difference in the decrease in intraocular pressure as compared with the T1, N2, and T2 approaches (p=0.0014). The baseline intraocular pressure (p=0.021) and anterior chamber angle sector (N1; p=0.044) correlated with decreased intraocular pressure. Conclusion: Compared with the temporal approach, 180° selective laser trabeculoplasty performed initially in the nasal sector was associated with a more significant decrease in intraocular pressure. Considering the sectorial differences in the anterior chamber angle, further prospective trials are warranted to confirm our findings and provide more-efficient selective laser trabeculoplasty protocols.
DOI: 10.6084/m9.figshare.23300517.v1
title: Comparison of the short-term results of nasal and temporal 180° selective laser trabeculoplasties for open-angle glaucoma

description: ABSTRACT Purpose: The nasal sector of the anterior chamber angle may present a higher density of collector channels, which may influence the results of angle surgeries. Considering the anatomical differences in the anterior chamber angle, we compared the results of the nasal and temporal 180° selective laser trabeculoplasty approaches for open-angle glaucoma. Methods: A retrospective chart review was conducted for patients with open-angle glaucoma (primary, pseudoexfoliation, and pigmentary) who underwent at least one 180° selective laser trabeculoplasty session between December 2016 and October 2018. The nasal (N1) or temporal (T1) sectors were chosen at the physician’s discretion. Patients who did not experience decreased intraocular pressure between 3 and 6 months again underwent 180° selective laser trabeculoplasty in the opposite angle sector (T2 and N2). The main outcome measured was decrease in intraocular pressure at 6-month follow-up, after the last selective laser trabeculoplasty. A multivariable regression analysis was used to evaluate factors associated with decreased intraocular pressure after treatment. Results: The procedure was performed initially in 45 eyes (N1, 25; T1, 20 eyes) and repeated in the opposite anterior chamber angle sector in 19 eyes (N2, 11; T2, 8 eyes). Analysis of variance revealed that only the N1 approach presented a significant difference in the decrease in intraocular pressure as compared with the T1, N2, and T2 approaches (p=0.0014). The baseline intraocular pressure (p=0.021) and anterior chamber angle sector (N1; p=0.044) correlated with decreased intraocular pressure. Conclusion: Compared with the temporal approach, 180° selective laser trabeculoplasty performed initially in the nasal sector was associated with a more significant decrease in intraocular pressure. Considering the sectorial differences in the anterior chamber angle, further prospective trials are warranted to confirm our findings and provide more-efficient selective laser trabeculoplasty protocols.
DOI: 10.6084/m9.figshare.23300522.v1
title: Validation studies on migraine diagnostic tools for use in nonclinical settings: a systematic review

description: Abstract Background Migraine underdiagnosis and undertreatment are so widespread, that hence is essential to diagnose migraine sufferers in nonclinical settings. A systematic review of validation studies on migraine diagnostic tools applicable to nonclinical settings can help researchers and practitioners in tool selection decisions. Objective To systematically review and critically assess published validation studies on migraine diagnostic tools for use in nonclinical settings, as well as to describe their diagnostic performance. Methods A multidisciplinary workgroup followed transparent and systematic procedures to collaborate on this work. PubMed, Medline, and Web of Science were searched for studies up to January 17, 2022. The QUADAS-2 was employed to assess methodological quality, and the quality thresholds adopted by the Global Burden Disease study were used to tail signaling questions. Results From 7,214 articles identified, a total of 27 studies examining 19 tools were eligible for inclusion. There has been no high-quality evidence to support any tool for use of migraine diagnosis in nonclinical settings. The diagnostic accuracy of the ID-migraine, structured headache and HARDSHIP questionnaires have been supported by moderate-quality evidence, with sensitivity and specificity above 70%. Of them, the HARDSHIP questionnaire has been the most extensively validated. The remaining 16 tools have provided poor-quality evidence for migraine diagnosis in nonclinical populations. Conclusions Up till now, the HARDSHIP questionnaire is the optimal choice for diagnosing migraine in nonclinical settings, with satisfactory diagnostic accuracy supported by moderate methodological quality. This work reveals the crucial next step, which is further high-quality validation studies in diverse nonclinical population groups.
DOI: 10.6084/m9.figshare.23300522
title: Validation studies on migraine diagnostic tools for use in nonclinical settings: a systematic review

description: Abstract Background Migraine underdiagnosis and undertreatment are so widespread, that hence is essential to diagnose migraine sufferers in nonclinical settings. A systematic review of validation studies on migraine diagnostic tools applicable to nonclinical settings can help researchers and practitioners in tool selection decisions. Objective To systematically review and critically assess published validation studies on migraine diagnostic tools for use in nonclinical settings, as well as to describe their diagnostic performance. Methods A multidisciplinary workgroup followed transparent and systematic procedures to collaborate on this work. PubMed, Medline, and Web of Science were searched for studies up to January 17, 2022. The QUADAS-2 was employed to assess methodological quality, and the quality thresholds adopted by the Global Burden Disease study were used to tail signaling questions. Results From 7,214 articles identified, a total of 27 studies examining 19 tools were eligible for inclusion. There has been no high-quality evidence to support any tool for use of migraine diagnosis in nonclinical settings. The diagnostic accuracy of the ID-migraine, structured headache and HARDSHIP questionnaires have been supported by moderate-quality evidence, with sensitivity and specificity above 70%. Of them, the HARDSHIP questionnaire has been the most extensively validated. The remaining 16 tools have provided poor-quality evidence for migraine diagnosis in nonclinical populations. Conclusions Up till now, the HARDSHIP questionnaire is the optimal choice for diagnosing migraine in nonclinical settings, with satisfactory diagnostic accuracy supported by moderate methodological quality. This work reveals the crucial next step, which is further high-quality validation studies in diverse nonclinical population groups.
DOI: 10.6084/m9.figshare.23259468
title: Numerical analysis of fluid-body interaction considering vortex and tornado-like flows

description: Abstract A numerical analysis of fluid-body interaction is performed in this work in order to evaluate the influence of vortex and tornado-like flows on immersed objects. Velocity profile models are adopted to generate vortical flow fields based on time-dependent boundary conditions and a finite element formulation is used for spatial discretization, where eight-node hexahedral elements with one-point integration are adopted. In addition, an arbitrary Lagrangian-Eulerian (ALE) approach is proposed to describe the relative motion between vortex flow and immersed objects. The flow governing equations are discretized using an explicit two-step Taylor-Galerkin scheme and tornado flow fields are simulated using the Rankine Combined Vortex Model (RCVM) and the Vatistas Model. Turbulence modeling is performed using Large Eddy Simulation (LES) with the Smagorinsky’s sub-grid scale model. Problems involving moving and stationary tornadoes interacting with fixed and moving objects are analyzed, where significant aerodynamic forces are observed on the immersed bodies, producing also significant changes in the vortex flow characteristics.
DOI: 10.6084/m9.figshare.23259468.v1
title: Numerical analysis of fluid-body interaction considering vortex and tornado-like flows

description: Abstract A numerical analysis of fluid-body interaction is performed in this work in order to evaluate the influence of vortex and tornado-like flows on immersed objects. Velocity profile models are adopted to generate vortical flow fields based on time-dependent boundary conditions and a finite element formulation is used for spatial discretization, where eight-node hexahedral elements with one-point integration are adopted. In addition, an arbitrary Lagrangian-Eulerian (ALE) approach is proposed to describe the relative motion between vortex flow and immersed objects. The flow governing equations are discretized using an explicit two-step Taylor-Galerkin scheme and tornado flow fields are simulated using the Rankine Combined Vortex Model (RCVM) and the Vatistas Model. Turbulence modeling is performed using Large Eddy Simulation (LES) with the Smagorinsky’s sub-grid scale model. Problems involving moving and stationary tornadoes interacting with fixed and moving objects are analyzed, where significant aerodynamic forces are observed on the immersed bodies, producing also significant changes in the vortex flow characteristics.
DOI: 10.6084/m9.figshare.23300523
title: At the margins of ancient Mediterranean urbanism: settlements and social organization in Samnium, central Italy, 4th-1st centuries BCE

description: ABSTRACT There is still debate as to whether non-urbanized regions of the ancient world developed forms of socioeconomic and political organization that diverged significantly from those in city-state contexts. This article addresses the issue by focusing on Samnium, in the uplands of central Italy, which has been considered a periphery of Mediterranean urbanism. According to modern reconstructions, in the last four centuries BCE, the region’s dispersed settlement system would have supported alternative forms of sociopolitical organization based on ethnic or “tribal” rather than civic identification. I propose to develop this view by analysing a sample of settlement sites that were apparently exceptional in the region, owing to their increased size, their large-scale public structures, and particularly their diverse range of socioeconomic activities and occupations. I delineate some important implications of these settlements for our understanding of this non-urbanized context, in terms of the socioeconomic profile of such centres (possibly more egalitarian in terms of the social division of manual labour and access to material comfort), as well as of the political dimension these places may have developed, acting at times jointly, at others alternatively to broader ethnic settlements. The aim is to contribute with interpretative parameters for the study of less- or non-urbanized societies of the remote past.
DOI: 10.6084/m9.figshare.23300523.v1
title: At the margins of ancient Mediterranean urbanism: settlements and social organization in Samnium, central Italy, 4th-1st centuries BCE

description: ABSTRACT There is still debate as to whether non-urbanized regions of the ancient world developed forms of socioeconomic and political organization that diverged significantly from those in city-state contexts. This article addresses the issue by focusing on Samnium, in the uplands of central Italy, which has been considered a periphery of Mediterranean urbanism. According to modern reconstructions, in the last four centuries BCE, the region’s dispersed settlement system would have supported alternative forms of sociopolitical organization based on ethnic or “tribal” rather than civic identification. I propose to develop this view by analysing a sample of settlement sites that were apparently exceptional in the region, owing to their increased size, their large-scale public structures, and particularly their diverse range of socioeconomic activities and occupations. I delineate some important implications of these settlements for our understanding of this non-urbanized context, in terms of the socioeconomic profile of such centres (possibly more egalitarian in terms of the social division of manual labour and access to material comfort), as well as of the political dimension these places may have developed, acting at times jointly, at others alternatively to broader ethnic settlements. The aim is to contribute with interpretative parameters for the study of less- or non-urbanized societies of the remote past.
DOI: 10.6084/m9.figshare.23300525
title: History and national survey on reflex hammers: which is the chosen one of Brazilian neurologists?

description: Abstract Background Percussion is an important part of the neurological examination and reflex hammers are necessary to obtain it properly. Objective We aimed to review the historical aspects of the main reflex hammers and to define the favorite one of Brazilian neurologists. Methods We searched original and review articles about historical aspects of the reflex hammers in Scielo and Pubmed and conducted an online survey to investigate the favorite reflex hammer of Brazilian neurologists. Results In the first part, we describe the major milestones in the creation of the reflex hammers. Following, we exhibit the results of the online survey: Babinski-Rabiner was the most voted. Conclusions The origins of the reflex hammers goes back long before their creation, from a basic clinical examination method: percussion. Since the description of deep tendon reflexes and the creation of percussion hammers, much has been improved in this technique. Among all the hammers surveyed, the Babinski-Rabiner was the chosen one by a significant portion of Brazilian neurologists.