cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.19492612
title: Human umbilical vein endothelial cells-derived exosomes enhance cardiac function after acute myocardial infarction by activating the PI3K/AKT signaling pathway

description: Currently, acute myocardial infarction (AMI) is one of the leading causes of human health issues worldwide. The sudden and continuous occlusion of the coronary artery results in myocardial hypoxic-ischemic necrosis, which is accompanied by inflammatory infiltration and fibrosis, leading to pathological cardiac remodeling. Exosome-based therapy is a promising cell-free approach for repairing the ischemic myocardium. This study aimed to explore the effects and mechanism of human umbilical vein endothelial cells (HUVECs)-derived exosomes on AMI. The results indicated that the localized injection of HUVECs-derived exosomes in the infarcted area could significantly improve cardiac function in AMI mouse models. It could also ameliorate myocardial fibrosis and decrease infarct size after AMI. Additionally, HUVECs-derived exosomes had cardioprotective effects on the H9C2 cells in hypoxic culture conditions, including increased cell viability and decreased lactate dehydrogenase (LDH) release. In both the <i>in-vivo</i> and <i>in-vitro</i> experiments, HUVECs-derived exosomes could effectively inhibit cardiomyocyte apoptosis. The low expression levels of Bcl-2–associated X protein (Bax) and cleaved caspase-3, high expression levels of B-cell lymphoma 2 (Bcl-2), phosphorylated phosphatidylinositol 3-kinase (p-PI3K), and phosphorylated protein kinase B (p-AKT) were detected in AMI mouse models treated with HUVECs-derived exosomes <i>in-vivo</i>. In conclusion, HUVECs-derived exosomes effectively enhanced cardiac function after AMI and inhibited cardiomyocyte apoptosis, which might be regulated through the phosphatidylinositol 3-kinase (PI3K)/ protein kinase B (AKT) signaling pathway.
DOI: 10.6084/m9.figshare.19492612.v1
title: Human umbilical vein endothelial cells-derived exosomes enhance cardiac function after acute myocardial infarction by activating the PI3K/AKT signaling pathway

description: Currently, acute myocardial infarction (AMI) is one of the leading causes of human health issues worldwide. The sudden and continuous occlusion of the coronary artery results in myocardial hypoxic-ischemic necrosis, which is accompanied by inflammatory infiltration and fibrosis, leading to pathological cardiac remodeling. Exosome-based therapy is a promising cell-free approach for repairing the ischemic myocardium. This study aimed to explore the effects and mechanism of human umbilical vein endothelial cells (HUVECs)-derived exosomes on AMI. The results indicated that the localized injection of HUVECs-derived exosomes in the infarcted area could significantly improve cardiac function in AMI mouse models. It could also ameliorate myocardial fibrosis and decrease infarct size after AMI. Additionally, HUVECs-derived exosomes had cardioprotective effects on the H9C2 cells in hypoxic culture conditions, including increased cell viability and decreased lactate dehydrogenase (LDH) release. In both the <i>in-vivo</i> and <i>in-vitro</i> experiments, HUVECs-derived exosomes could effectively inhibit cardiomyocyte apoptosis. The low expression levels of Bcl-2–associated X protein (Bax) and cleaved caspase-3, high expression levels of B-cell lymphoma 2 (Bcl-2), phosphorylated phosphatidylinositol 3-kinase (p-PI3K), and phosphorylated protein kinase B (p-AKT) were detected in AMI mouse models treated with HUVECs-derived exosomes <i>in-vivo</i>. In conclusion, HUVECs-derived exosomes effectively enhanced cardiac function after AMI and inhibited cardiomyocyte apoptosis, which might be regulated through the phosphatidylinositol 3-kinase (PI3K)/ protein kinase B (AKT) signaling pathway.
DOI: 10.6084/m9.figshare.13725405
title: Additional file 10 of Noninvasive prenatal testing of α-thalassemia and β-thalassemia through population-based parental haplotyping

description: Additional file 10: Source data for Fig. S1.
DOI: 10.6084/m9.figshare.13725432.v1
title: Additional file 9 of Noninvasive prenatal testing of α-thalassemia and β-thalassemia through population-based parental haplotyping

description: Additional file 9: Source data for Fig. 3.
DOI: 10.6084/m9.figshare.22638621.v1
title: Mathematical model for estimating the leaf area of cured dry tobacco using linear measurements

description: ABSTRACT: Leaf area of dried Flue-cured tobacco is a reflection of climate and stage of growth of fresh tobacco in field; it also serves as the foundation for calculating a number of significant physical properties of tobacco. So the purpose of this paper was to establish a model to estimate the leaf area of dried Flue-cured tobacco in China from linear dimensions. Three Hundred eight tobacco leaves from different growing area and stalk position were sampled randomly and separated for model selection among linear, proportional and power model type and external evaluation individually. Results showed that there was a significant and strong correlation between leaf area and length×width , The equation LA = 0.495(L×W), where LA is the leaf area and L×W is the product of leaf length and width, was optimum and adequate for the estimation of leaf area of dried tobacco in China examined by Fisher’s test, Akaike delta information criterion (AIC) and Bayesian information criterion (BIC). Growing area and stalk position had minor effect on the parameter before (L×W). The equation can sufficiently predict the area of leaf for external evaluation.
DOI: 10.25549/usctheses-ouc11258113
title: 00001.tif
DOI: 10.6084/m9.figshare.23691672
title: <b>Microplastic emission and socioeconomic data of fashion industry in Chinese cities from 2001 to 2020</b>

description: Microplastic pollution is one of the emerging global environmental issues. The fashion industry is a major source of microplastic pollution due to the massive consumption of synthetic fibres. Textile, garment, and footwear manufacturing contribute to the microplastic emission into sewage waters. Cities are major contributors to microplastic emissions and the implementers of microplastic control. It is important to compile the inventories of microplastic emissions of the fashion industry for cities, and fewer studies have investigated the inventories of microplastic emissions for key industries in cities. This study, for the first time, compiles microplastic emission inventories of the fashion industry for Chinese cities. The inventories are constructed using 21 cities and 4 production processes of the fashion industry. The socioeconomic data of the fashion industry in cities such as the output of industrial products and the gross output value of the fashion industry are included in the datasets as well. The dataset can provide transparent, comparable, and verifiable data support for the microplastic pollution prevention and control strategies in the fashion industry, and provide references for the construction of microplastic emission inventories for other key industries.
DOI: 10.6084/m9.figshare.22638714
title: Nutrition management by a multidisciplinary team for prevention of nutritional deficits and morbidity following esophagectomy

description: This study evaluated the effects of perioperative nutrition management by a multidisciplinary team on nutrition and postoperative complications of patients with esophageal cancer. A total of 239 patients with esophageal cancer who underwent esophagectomy and gastric conduit reconstruction for esophageal or esophagogastric junction cancer between February 2019 and February 2020 were included in the study. They were divided into the experimental group (120 patients) and the control group (119 patients) using the random number table method. Control group patients received routine diet management and experimental group patients received perioperative nutrition management by a multidisciplinary team. The differences of nutriture and postoperative complications between the two groups were compared. At 3 and 7 days after surgery, the experimental group patients had higher total protein and albumin levels (P&lt;0.05), shorter postoperative anal exhaust time (P&lt;0.05), lower incidence of postoperative gastrointestinal adverse reactions, pneumonia, anastomotic fistula, hypoproteinemia (P&lt;0.05), and lower hospitalization costs (P&lt;0.05) than the control group. Nutrition management by a multidisciplinary team effectively improved the nutriture of patients, promoted the rapid recovery of postoperative gastrointestinal function, reduced postoperative complications, and reduced hospitalization costs.
DOI: 10.6084/m9.figshare.14774343.v1
title: WRKY54 and WRKY70 positively regulate <i>SARD1</i> and <i>CBP60g</i> expression in plant immunity

description: SARD1 and CBP60g are two master regulators in plant immunity. They are required for the constitutive defense responses in the Arabidopsis <i>snc2-1D</i> mutant, which carries a gain-of-function mutation in a receptor-like protein. Here we report that WRKY54 and WRKY70 are required for activation of <i>SARD1</i> and <i>CBP60g</i> expression and defense responses in <i>snc2-1D</i>. In addition, the induction of <i>SARD1</i> and <i>CBP60g</i> by the bacterial pathogen <i>Pseudomonas syringae</i> pv. <i>maculicola</i> is significantly reduced in <i>sid2 wrky54 wrky70</i> triple mutants compared to the <i>sid2</i> single mutants, suggesting that WRKY54 and WRKY70 positively regulate the <i>SID2</i>-independent expression of <i>SARD1</i> and <i>CBP60g</i> during pathogen infection. Our study revealed WRKY54 and WRKY70 as positive regulators of <i>SARD1</i> and <i>CBP60g</i> expression in plant defense.
DOI: 10.6084/m9.figshare.22638714.v1
title: Nutrition management by a multidisciplinary team for prevention of nutritional deficits and morbidity following esophagectomy

description: This study evaluated the effects of perioperative nutrition management by a multidisciplinary team on nutrition and postoperative complications of patients with esophageal cancer. A total of 239 patients with esophageal cancer who underwent esophagectomy and gastric conduit reconstruction for esophageal or esophagogastric junction cancer between February 2019 and February 2020 were included in the study. They were divided into the experimental group (120 patients) and the control group (119 patients) using the random number table method. Control group patients received routine diet management and experimental group patients received perioperative nutrition management by a multidisciplinary team. The differences of nutriture and postoperative complications between the two groups were compared. At 3 and 7 days after surgery, the experimental group patients had higher total protein and albumin levels (P&lt;0.05), shorter postoperative anal exhaust time (P&lt;0.05), lower incidence of postoperative gastrointestinal adverse reactions, pneumonia, anastomotic fistula, hypoproteinemia (P&lt;0.05), and lower hospitalization costs (P&lt;0.05) than the control group. Nutrition management by a multidisciplinary team effectively improved the nutriture of patients, promoted the rapid recovery of postoperative gastrointestinal function, reduced postoperative complications, and reduced hospitalization costs.
DOI: 10.6084/m9.figshare.7434971.v1
title: Additional file 7: of Genetic variation of dynamic fiber elongation and developmental quantitative trait locus mapping of fiber length in upland cotton (Gossypium hirsutum L.)

description: Table S5. Correlation coefficients between SNP markers and FL at maturity in CRI36 × Hai 7124 BILs. (XLSX 9 kb)
DOI: 10.6084/m9.figshare.16871898
title: Synthesis, characterisation, and effects of molecular structure on phase behaviour of 4-chloro-1,3-diazobenzene bent-core liquid crystals with high photosensitivity

description: A series of new compounds were synthesised by adding azo functional groups and chlorine substituent to the central bent-cores to form a 4-chloro-1,3-dizaophenylene bent-core. The structure, mesogenic properties, and photosensitivity of these compounds were characterised. The results show these synthesised compounds exhibit a broad temperature window up to 63.8°C for nematic phase and the rapid rate of <i>trans – cis</i> photoisomerisation. For instance, at 95°C, compound <b>4c</b> in nematic phase became an isotropic liquid under UV-irradiation in 3 s and could be restored to nematic under natural visible light in 5 s. Quantum mechanics calculation confirms that using azos instead of esters as the central linkages can effectively reduce the molecular dipole moment, which appears to promote favourable mesogenic and photonic characteristics. Moreover, varying the carbon number in the terminal alkyl chains can alter molecular dipole moment and polarisability anisotropy, which are strongly correlated with the phase transition temperature and temperature range of the nematic phase. These findings suggest that 1) changing azo group position can effectively alter the intermolecular interactions by varying molecular polarity and polarisability; 2) reducing long-range electrostatic interactions can promote favourable mesogenic and possibly photonic properties of azobenzene bent-core liquid crystal.
DOI: 10.6084/m9.figshare.13719024
title: Additional file 4 of Comparison between nab-paclitaxel and solvent-based taxanes as neoadjuvant therapy in breast cancer: a systematic review and meta-analysis

description: Additional file 4: Supplementary Figure S4. (A) Funnel plot of pathological complete response (pCR). (B) Funnel plot of objective response rate (ORR).
DOI: 10.6084/m9.figshare.7434740.v1
title: Additional file 3: of A high density SLAF-SNP genetic map and QTL detection for fibre quality traits in Gossypium hirsutum

description: Table S3. Details of QTL Clusters for fiber quality traits (XLSX 14 kb)
DOI: 10.6084/m9.figshare.20018043
title: miR-34a regulates phenotypic modulation of vascular smooth muscle cells in intracranial aneurysm by targeting CXCR3 and MMP-2

description: Abstract MicroRNAs (miRNAs) dysregulation is tightly related to diseases including tumor, neuro disease and cardiovascular disease. In this study, we investigated the potential biological effects of miR-34a and its target CXCR3 in phenotypic modulation of vascular smooth muscle cells (VSMCs) of intracranial aneurysms (IAs). MiR-34a was found to be down-regulated in IAs patients tested by Real-time PCR and decreased in GEO data. Meanwhile, our study also showed miR-34a inhibited matrix metalloproteinases (MMPs) and migration of VSMCs. Besides, CXCR3 is a direct target of miR-34a identified via luciferase assay. CXCR3 showed inhibitory effect on SM-MHC, SM22 while promoted MMPs expression, cell proliferation and migration in VSMCs. MiR-34a reversed the effect of CXCR3 in VSMCs. In addition, MMP-2 is a competitive endogenous RNA (ceRNA) of CXCR3 sharing common miR-34a target. CXCR3 increased MMP-2 level through competitive endogenous RNA regulation by sponging endogenous miR-34a. In conclusion, miR-34a is down-regulated in IAs while CXCR3 is the direct target of miR-34a that regulates phenotypic modulation of VSMCs. CXCR3 increased MMP-2 level through competitive endogenous RNA regulation by sharing common miR-34a targets.
DOI: 10.6084/m9.figshare.20018043.v1
title: miR-34a regulates phenotypic modulation of vascular smooth muscle cells in intracranial aneurysm by targeting CXCR3 and MMP-2

description: Abstract MicroRNAs (miRNAs) dysregulation is tightly related to diseases including tumor, neuro disease and cardiovascular disease. In this study, we investigated the potential biological effects of miR-34a and its target CXCR3 in phenotypic modulation of vascular smooth muscle cells (VSMCs) of intracranial aneurysms (IAs). MiR-34a was found to be down-regulated in IAs patients tested by Real-time PCR and decreased in GEO data. Meanwhile, our study also showed miR-34a inhibited matrix metalloproteinases (MMPs) and migration of VSMCs. Besides, CXCR3 is a direct target of miR-34a identified via luciferase assay. CXCR3 showed inhibitory effect on SM-MHC, SM22 while promoted MMPs expression, cell proliferation and migration in VSMCs. MiR-34a reversed the effect of CXCR3 in VSMCs. In addition, MMP-2 is a competitive endogenous RNA (ceRNA) of CXCR3 sharing common miR-34a target. CXCR3 increased MMP-2 level through competitive endogenous RNA regulation by sponging endogenous miR-34a. In conclusion, miR-34a is down-regulated in IAs while CXCR3 is the direct target of miR-34a that regulates phenotypic modulation of VSMCs. CXCR3 increased MMP-2 level through competitive endogenous RNA regulation by sharing common miR-34a targets.
DOI: 10.6084/m9.figshare.7434872
title: Additional file 1: of Genetic variation of dynamic fiber elongation and developmental quantitative trait locus mapping of fiber length in upland cotton (Gossypium hirsutum L.)

description: Table S1. List of 83 upland accessions used for association mapping. P1 and P2 indicate the 83 upland cotton accessions grouped into two subpopulations by genotypes; the clustering indicates that the 83 upland cotton accessions were divided into two clusters by average growth rate trend of fiber length at the fast-elongation stage in the three years, and the letters A and B represent the cultivars in Fig. 1a and Fig. 1b, respectively. Table S2. List of 10 Sea Island cotton accessions. (XLSX 16â kb)
DOI: 10.6084/m9.figshare.7434722
title: Additional file 2: of A high density SLAF-SNP genetic map and QTL detection for fibre quality traits in Gossypium hirsutum

description: Table S2. QTL for fiber quality in RIL population in three environments (XLSX 20 kb)
DOI: 10.6084/m9.figshare.7434761
title: Additional file 4: of A high density SLAF-SNP genetic map and QTL detection for fibre quality traits in Gossypium hirsutum

description: Table S4. Common QTL compared with CottonQTLdb (XLSX 15 kb)
DOI: 10.6084/m9.figshare.16871898.v1
title: Synthesis, characterisation and effects of molecular structure on phase behaviour of 4-chloro-1,3-diazobenzene bent-core liquid crystals with high photosensitivity

description: A series of new compounds were synthesised by adding azo functional groups and chlorine substituent to the central bent-cores to form a 4-chloro-1,3-dizaophenylene bent-core. The structure, mesogenic properties, and photosensitivity of these compounds were characterised. The results show these synthesised compounds exhibit a broad temperature window up to 63.8°C for nematic phase and the rapid rate of <i>trans – cis</i> photoisomerisation. For instance, at 95°C, compound <b>4c</b> in nematic phase became an isotropic liquid under UV-irradiation in 3 s and could be restored to nematic under natural visible light in 5 s. Quantum mechanics calculation confirms that using azos instead of esters as the central linkages can effectively reduce the molecular dipole moment, which appears to promote favourable mesogenic and photonic characteristics. Moreover, varying the carbon number in the terminal alkyl chains can alter molecular dipole moment and polarisability anisotropy, which are strongly correlated with the phase transition temperature and temperature range of the nematic phase. These findings suggest that 1) changing azo group position can effectively alter the intermolecular interactions by varying molecular polarity and polarisability; 2) reducing long-range electrostatic interactions can promote favourable mesogenic and possibly photonic properties of azobenzene bent-core liquid crystal.
DOI: 10.6084/m9.figshare.7434698.v1
title: Additional file 1: of A high density SLAF-SNP genetic map and QTL detection for fibre quality traits in Gossypium hirsutum

description: Table S1. Genome coverage of genetic map (XLSX 11 kb)
DOI: 10.6084/m9.figshare.7434740
title: Additional file 3: of A high density SLAF-SNP genetic map and QTL detection for fibre quality traits in Gossypium hirsutum

description: Table S3. Details of QTL Clusters for fiber quality traits (XLSX 14 kb)
DOI: 10.6084/m9.figshare.7434761.v1
title: Additional file 4: of A high density SLAF-SNP genetic map and QTL detection for fibre quality traits in Gossypium hirsutum

description: Table S4. Common QTL compared with CottonQTLdb (XLSX 15 kb)
DOI: 10.5281/zenodo.10635915
title: Encuesta de Presupuestos Familiares: Microdatos 2006-2021

description: Fuente: INE
DOI: 10.5281/zenodo.10635916
title: Encuesta de Presupuestos Familiares: Microdatos 2006-2021

description: Fuente: INE
DOI: 10.6084/m9.figshare.5862312.v1
title: Exploring the natural chemiome to target interleukin-6 receptor (IL-6R) cytokines: an atomic scale investigation for novel rheumatoid arthritis drug discovery

description: ABSTRACT Natural compounds are a gold mine for treating rheumatoid arthritis (RA). The etiology of this disease is linked to inflammation, where cytokines play an important role. Strategies have been drafted for targeting cytokines as a therapeutic option in patients with RA. Inhibiting cytokines with natural compounds has become a major focus for the development of drugs to treat RA. Here, a structure-based drug design approach was employed to identify novel leads to target the interleukin 6 receptor (IL-6R). A total of 48,531 compounds of natural origin were screened. Two of these compounds were shortlisted for molecular docking simulation and tested for inhibiting gp130 dimerization in human macrophages. The results show that Lead5 (CID5329098) significantly inhibited the release of gp130 in a dose-dependent manner, similar to the inhibitory effect of LMT-28 (p&lt;0.005). This study provides an atomic scale outcome of a single natural compound that can be developed into a RA drug.
DOI: 10.6084/m9.figshare.7434950.v1
title: Additional file 6: of Genetic variation of dynamic fiber elongation and developmental quantitative trait locus mapping of fiber length in upland cotton (Gossypium hirsutum L.)

description: Table S4. Genotype polymorphism of candidate SNPs between CRI36 and Hai 7124 and the primers used for HRM analysis. (XLSX 359â kb)
DOI: 10.6084/m9.figshare.20018108.v1
title: Expression of Ubiquitin-specific protease 7 in oral squamous cell carcinoma promotes tumor cell proliferation and invasion

description: Abstract Oral Squamous Cell Carcinoma (OSCC) is the most common malignant cancer affecting oral cavity. Recent studies have demonstrated that Ubiquitin-specific protease 7 (USP7) was upregulated in several types of cancers. USP7 expression was associated with various proto-oncogenes and tumor suppressor genes. However, USP7 expression level and its functional role in OSCC is unclear. In the current study, we showed that USP7 expression in OSCC tissues was generally upregulated compared to normal adjacent tissues by using IHC. Furthermore, statistical analysis uncovered that USP7 expression was positively correlated with Ki-67, MMP2, VEGF in OSCC tissues. Importantly, high USP7 expression was significantly correlated with lymph node metastasis and histological differentiation in OSCC patients. So, our hypothesis is that USP7 plays a tumor-promoting role in OSCC. Knocking down of USP7 in tumor cells not only suppressed HSC3 cells proliferation, migration and invasion, but also promoted cell apoptosis. Moreover, USP7 siRNA blocked the activation of Akt/ERK signaling pathway. In conclusion, data presented here suggests that USP7 promotes the progression of OSCC. USP7 may be used as a new therapeutic target for OSCC diagnosis and treatment.
DOI: 10.6084/m9.figshare.7434722.v1
title: Additional file 2: of A high density SLAF-SNP genetic map and QTL detection for fibre quality traits in Gossypium hirsutum

description: Table S2. QTL for fiber quality in RIL population in three environments (XLSX 20 kb)
DOI: 10.6084/m9.figshare.7434914
title: Additional file 4: of Genetic variation of dynamic fiber elongation and developmental quantitative trait locus mapping of fiber length in upland cotton (Gossypium hirsutum L.)

description: Table S3. Performance of backcross inbred lines (BILs) of Hai7124 × CRI36 hybrids and their parents. (XLSX 393 kb)