cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.5281/zenodo.16411249
title: Identification of New Therapeutic Targets for Renal Medullary Carcinoma via Integrated Genomic and Transcriptomic Profiling

description: Purpose: Renal medullary carcinoma (RMC) is a rare, aggressive kidney cancer associated with sickle cell trait, characterized by SMARCB1 loss and resistance to conventional therapies used for other renal cell carcinomas (RCC). This study aimed to perform comprehensive histopathologic, genomic, and transcriptomic profiling of RMC tissues to identify novel therapeutic targets.

Experimental Design: We conducted whole exome sequencing (WES) and bulk RNA-sequencing (RNA-seq) on 15 RMC samples, using cellular deconvolution to characterize the tumor microenvironment (TME) and identify potential therapeutic targets. Gene expression profiles and TME composition were compared with other RCCs, internally available cohorts of other solid and neuroendocrine tumors, and the Cancer Genome Atlas. Immunohistochemistry (IHC) confirmed TROP2 expression, and four heavily pretreated patients with high TROP2 expression were prospectively treated with sacituzumab govitecan. 

Results: There was significant upregulation of TROP2, EPCAM, CLDN6, and CDH6, positioning them as potential therapeutic targets. Pathway analyses indicated upregulation of the Hippo, pathway and distinct TME features, including high levels of fibroblasts and neutrophils. Among the four patients treated with sacituzumab govitecan, one achieved a partial response with symptom improvement, while two achieved stable disease. The median progression-free survival was 2.9 months.

Conclusions: This study provides the largest molecular characterization of RMC to date, highlighting TROP2 and other cell surface markers as promising therapeutic targets. Sacituzumab govitecan may offer clinical benefit for RMC patients with high TROP2 expression. Further investigation in prospective clinical trials is warranted to confirm the efficacy of TROP2-targeted therapies and explore additional targets like EPCAM and CLDN6.
description: This dataset contains transcriptomic profiles from the BostonGene PanSolid and RMC cohorts. PanSolid cohort includes 1,020 patients, with available RNA-Seq data for 1,020 samples; RMC cohort includes 25 patients, with available RNA-Seq data for 25 samples.

The archive includes:1) Annotation for BostonGene PanSolid cohort.2) Gene expression data in TPM (Transcripts Per Million) format for the 1,020 PanSolid cohort RNA-Seq samples, provided as a TSV file.3) Annotation for BostonGene RMC cohort.4) Gene expression data in TPM (Transcripts Per Million) format for the 25 RMC cohort RNA-Seq samples, provided as a TSV file.5) Copy number alteration data for 24 RMC cohort WES samples, provided as a TSV file.6) Somatic mutation data in MAF format for 24 RMC cohort WES samples, provided as a tab-separated file.
DOI: 10.15468/dl.9gev9r
title: Occurrence Download

description: A dataset containing 28327 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Hedwigia ciliata"
 ]
}

 The dataset includes 28327 records from 464 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0023058-251009101135966/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.5281/zenodo.15789256
title: INRIM_Test_1F_2_23C_0k_EDLC_single

description: Test

MetSuperCap Project Dataset 1F SC sample 2 INRIM

 Part of the Constant Temperature DataBase
DOI: 10.5281/zenodo.17157869
title: INRIM_Test_1F_2_23C_0k_EDLC_single

description: Test

MetSuperCap Project Dataset 1F SC sample 2 INRIM

 Part of the Constant Temperature DataBase
DOI: 10.60712/si-id236492.1
title: StrainInfo SI-ID 236492.1

description: StrainInfo dataset 236492 about a strain of Saccharomyces cerevisiae. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id236493.1
title: StrainInfo SI-ID 236493.1

description: StrainInfo dataset 236493 about a strain of Saccharomyces cerevisiae. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id236571.1
title: StrainInfo SI-ID 236571.1

description: StrainInfo dataset 236571 about a strain of Hanseniaspora guilliermondii. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id236572.1
title: StrainInfo SI-ID 236572.1

description: StrainInfo dataset 236572 about a strain of Hanseniaspora occidentalis. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id236573.1
title: StrainInfo SI-ID 236573.1

description: StrainInfo dataset 236573 about a strain of Hanseniaspora occidentalis. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id236574.1
title: StrainInfo SI-ID 236574.1

description: StrainInfo dataset 236574 about a strain of Hanseniaspora osmophila. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id236662.1
title: StrainInfo SI-ID 236662.1

description: StrainInfo dataset 236662 about a strain of Septobasidium carestianum. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id236663.1
title: StrainInfo SI-ID 236663.1

description: StrainInfo dataset 236663 about a strain of Sirobasidium magnum. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id236664.1
title: StrainInfo SI-ID 236664.1

description: StrainInfo dataset 236664 about a strain of Sirobasidium magnum. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id236665.1
title: StrainInfo SI-ID 236665.1

description: StrainInfo dataset 236665 about a strain of Sphacelotheca polygoni-persicariae. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id236494.1
title: StrainInfo SI-ID 236494.1

description: StrainInfo dataset 236494 about a strain of Saccharomyces cerevisiae. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id236495.1
title: StrainInfo SI-ID 236495.1

description: StrainInfo dataset 236495 about a strain of Saccharomyces cerevisiae. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id236496.1
title: StrainInfo SI-ID 236496.1

description: StrainInfo dataset 236496 about a strain of Saccharomyces cerevisiae. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id236497.1
title: StrainInfo SI-ID 236497.1

description: StrainInfo dataset 236497 about a strain of Saccharomyces cerevisiae. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id236575.1
title: StrainInfo SI-ID 236575.1

description: StrainInfo dataset 236575 about a strain of Hanseniaspora osmophila. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id236576.1
title: StrainInfo SI-ID 236576.1

description: StrainInfo dataset 236576 about a strain of Hanseniaspora osmophila. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id236577.1
title: StrainInfo SI-ID 236577.1

description: StrainInfo dataset 236577 about a strain of Hanseniaspora osmophila. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id236578.1
title: StrainInfo SI-ID 236578.1

description: StrainInfo dataset 236578 about a strain of Hanseniaspora uvarum. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.15468/dl.dqecub
title: Occurrence Download

description: A dataset containing 3205 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Proteales",
 "HasCoordinate is true",
 "Country is Japan",
 "HasGeospatialIssue is false"
 ]
}

 The dataset includes 3205 records from 71 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0068356-230530130749713/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.60712/si-id236666.1
title: StrainInfo SI-ID 236666.1

description: StrainInfo dataset 236666 about a strain of Sporobolomyces johnsonii. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.15468/dl.ufhjz7
title: Occurrence Download

description: A dataset containing 8909 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Ludwigia peploides subsp. montevidensis (Spreng.) P.H.Raven"
 ]
}

 The dataset includes 8909 records from 154 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0260795-220831081235567/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.60712/si-id236667.1
title: StrainInfo SI-ID 236667.1

description: StrainInfo dataset 236667 about a strain of Sporobolomyces johnsonii. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id236668.1
title: StrainInfo SI-ID 236668.1

description: StrainInfo dataset 236668 about a strain of Rhodosporidiobolus microsporus. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id236669.1
title: StrainInfo SI-ID 236669.1

description: StrainInfo dataset 236669 about a strain of Sporobolomyces pararoseus. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id236498.1
title: StrainInfo SI-ID 236498.1

description: StrainInfo dataset 236498 about a strain of Saccharomyces cerevisiae. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id236499.1
title: StrainInfo SI-ID 236499.1

description: StrainInfo dataset 236499 about a strain of Saccharomyces cerevisiae. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id236500.1
title: StrainInfo SI-ID 236500.1

description: StrainInfo dataset 236500 about a strain of Saccharomyces cerevisiae. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id236501.1
title: StrainInfo SI-ID 236501.1

description: StrainInfo dataset 236501 about a strain of Saccharomyces cerevisiae. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.15468/dl.jhpgp9
title: Occurrence Download

description: A dataset containing 65 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Zygophyllales",
 "HasCoordinate is true",
 "Country is Japan",
 "HasGeospatialIssue is false"
 ]
}

 The dataset includes 65 records from 3 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0067986-230530130749713/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.60712/si-id236579.1
title: StrainInfo SI-ID 236579.1

description: StrainInfo dataset 236579 about a strain of Hanseniaspora uvarum. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id236580.1
title: StrainInfo SI-ID 236580.1

description: StrainInfo dataset 236580 about a strain of Hanseniaspora uvarum. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id236581.1
title: StrainInfo SI-ID 236581.1

description: StrainInfo dataset 236581 about a strain of Hanseniaspora valbyensis. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id236582.1
title: StrainInfo SI-ID 236582.1

description: StrainInfo dataset 236582 about a strain of Hanseniaspora valbyensis. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id236670.1
title: StrainInfo SI-ID 236670.1

description: StrainInfo dataset 236670 about a strain of Sporobolomyces pararoseus. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id236671.1
title: StrainInfo SI-ID 236671.1

description: StrainInfo dataset 236671 about a strain of Rhodosporidiobolus ruineniae. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id236672.1
title: StrainInfo SI-ID 236672.1

description: StrainInfo dataset 236672 about a strain of Sporobolomyces salmonicolor. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id236673.1
title: StrainInfo SI-ID 236673.1

description: StrainInfo dataset 236673 about a strain of Sporobolomyces salmonicolor. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.6084/m9.figshare.24878181
title: Untitled Item

description: just for
DOI: 10.60712/si-id236502.1
title: StrainInfo SI-ID 236502.1

description: StrainInfo dataset 236502 about a strain of Saccharomyces cerevisiae. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id236503.1
title: StrainInfo SI-ID 236503.1

description: StrainInfo dataset 236503 about a strain of Saccharomyces cerevisiae. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id236504.1
title: StrainInfo SI-ID 236504.1

description: StrainInfo dataset 236504 about a strain of Saccharomyces cerevisiae. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id236505.1
title: StrainInfo SI-ID 236505.1

description: StrainInfo dataset 236505 about a strain of Saccharomyces cerevisiae. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id236583.1
title: StrainInfo SI-ID 236583.1

description: StrainInfo dataset 236583 about a strain of Hanseniaspora vineae. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.15468/dl.uygu43
title: Occurrence Download

description: A dataset containing 960 species occurrences available in GBIF matching the query:
{
 "and" : [
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 "TaxonKey is Protoperidinium granii (Ostenfeld) Balech, 1974"
 ]
}

 The dataset includes 960 records from 14 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0367251-210914110416597/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.60712/si-id236584.1
title: StrainInfo SI-ID 236584.1

description: StrainInfo dataset 236584 about a strain of Hanseniaspora vineae. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id236585.1
title: StrainInfo SI-ID 236585.1

description: StrainInfo dataset 236585 about a strain of Holtermannia corniformis. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id236586.1
title: StrainInfo SI-ID 236586.1

description: StrainInfo dataset 236586 about a strain of Holtermannia corniformis. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id236674.1
title: StrainInfo SI-ID 236674.1

description: StrainInfo dataset 236674 about a strain of Unidentified. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id236675.1
title: StrainInfo SI-ID 236675.1

description: StrainInfo dataset 236675 about a strain of Colacogloea falcata. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id236676.1
title: StrainInfo SI-ID 236676.1

description: StrainInfo dataset 236676 about a strain of Kluyveromyces lactis. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id236677.1
title: StrainInfo SI-ID 236677.1

description: StrainInfo dataset 236677 about a strain of Kluyveromyces lactis. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id236506.1
title: StrainInfo SI-ID 236506.1

description: StrainInfo dataset 236506 about a strain of Saccharomyces cerevisiae. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id236507.1
title: StrainInfo SI-ID 236507.1

description: StrainInfo dataset 236507 about a strain of Saccharomyces cerevisiae. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id236508.1
title: StrainInfo SI-ID 236508.1

description: StrainInfo dataset 236508 about a strain of Saccharomyces cerevisiae. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.