cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.5281/zenodo.6365708
title: Dataset related to article "Distinct responses of newly identified monocyte subsets to advanced gastrointestinal cancer and COVID-19"

description: This record contains raw data related to article “ Distinct responses of newly identified monocyte subsets to advanced gastrointestinal cancer and COVID-19" Monocytes are critical cells of the immune system but their role as effectors is relatively poorly understood, as they have long been considered only as precursors of tissue macrophages or dendritic cells. Moreover, it is known that this cell type is heterogeneous, but our understanding of this aspect is limited to the broad classification in classical/intermediate/non-classical monocytes, commonly based on their expression of only two markers, i.e. CD14 and CD16. We deeply dissected the heterogeneity of human circulating monocytes in healthy donors by transcriptomic analysis at single-cell level and identified 9 distinct monocyte populations characterized each by a profile suggestive of specialized functions. The classical monocyte subset in fact included five distinct populations, each enriched for transcriptomic gene sets related to either inflammatory, neutrophil-like, interferon-related, and platelet-related pathways. Non-classical monocytes included two distinct populations, one of which marked specifically by elevated expression levels of complement components. Intermediate monocytes were not further divided in our analysis and were characterized by high levels of human leukocyte antigen (HLA) genes. Finally, we identified one cluster included in both classical and non-classical monocytes, characterized by a strong cytotoxic signature. These findings provided the rationale to exploit the relevance of newly identified monocyte populations in disease evolution. A machine learning approach was developed and applied to two single-cell transcriptome public datasets, from gastrointestinal cancer and Coronavirus disease 2019 (COVID-19) patients. The dissection of these datasets through our classification revealed that patients with advanced cancers showed a selective increase in monocytes enriched in platelet-related pathways. Of note, the signature associated with this population correlated with worse prognosis in gastric cancer patients. Conversely, after immunotherapy, the most activated population was composed of interferon-related monocytes, consistent with an upregulation in interferon-related genes in responder patients compared to non-responders. In COVID-19 patients we confirmed a global activated phenotype of the entire monocyte compartment, but our classification revealed that only cytotoxic monocytes are expanded during the disease progression. Collectively, this study unravels an unexpected complexity among human circulating monocytes and highlights the existence of specialized populations differently engaged depending on the pathological context.
description: Unraveling human monocyte heterogeneity in homeostasis and disease using a machine learning approach
DOI: 10.5519/qd.3ntyjcuv
title: Query on the Natural History Museum Data Portal (data.nhm.ac.uk) (34 records)
DOI: 10.5281/zenodo.7402285
title: Data from the NASCENT campaign used in the publications: "Conditions favorable for secondary ice production in Arctic mixed-phase clouds" and "Understanding the history of two complex ice crystal habits deduced from a holographic imager"

description: This repository contains the data from the Ny‐Ålesund AeroSol Cloud ExperimeNT campaign (NASCENT). This data were used to produce the figures in the two papers: (1) Pasquier, J. T., Henneberger, J., Ramelli, F., Korolev, A.,Wieder, J., Lauber, A., Li, G., David, R. O., Carlsen, T., Gierens, R., Maturilli, M., and Lohmann, U.: Understanding the history of two complex ice crystal habits deduced from a holographic imager, Geophys. Res. Lett., accepted, 2022 (2) Pasquier J. T., Henneberger J., Ramelli F., Lauber A., David O. D., Wieder J., Carlsen T., Gierens R., Maturilli M., and Lohmann U.:Conditions favorable for secondary ice production in Arctic mixed-phase clouds, ACP, accepted. More information can be found in the README files. The scripts to reproduced the Figures are available on Zenodo (1) https://doi.org/10.5281/zenodo.7402296 (2) https://doi.org/10.5281/zenodo.7407107
DOI: 10.5281/zenodo.7402284
title: Data from the NASCENT campaign used in the publications: "Conditions favorable for secondary ice production in Arctic mixed-phase clouds" and "Understanding the history of two complex ice crystal habits deduced from a holographic imager"

description: This repository contains the data from the Ny‐Ålesund AeroSol Cloud ExperimeNT campaign (NASCENT). This data were used to produce the figures in the two papers: (1) Pasquier, J. T., Henneberger, J., Ramelli, F., Korolev, A.,Wieder, J., Lauber, A., Li, G., David, R. O., Carlsen, T., Gierens, R., Maturilli, M., and Lohmann, U.: Understanding the history of two complex ice crystal habits deduced from a holographic imager, Geophys. Res. Lett., accepted, 2022 (2) Pasquier J. T., Henneberger J., Ramelli F., Lauber A., David O. D., Wieder J., Carlsen T., Gierens R., Maturilli M., and Lohmann U.:Conditions favorable for secondary ice production in Arctic mixed-phase clouds, ACP, accepted. More information can be found in the README files. The scripts to reproduced the Figures are available on Zenodo (1) https://doi.org/10.5281/zenodo.7402296 (2) https://doi.org/10.5281/zenodo.7407107
DOI: 10.25835/0072357
title: Megathrust Stress Drop as Trigger of Aftershock Seismicity: Insights From the 2011 Tohoku Earthquake, Japan

description: This data repository contains the data to the publication "Megathrust Stress Drop as Trigger of Aftershock Seismicity: Insights From the 2011 Tohoku Earthquake, Japan" by A. Dielforder, G. M. Bocchini, K. Kemna, A. Hampel, R. M. Harrington, and O. Oncken. https://doi.org/10.1029/2022GL101320
DOI: 10.5519/qd.nomhwczh
title: Query on the Natural History Museum Data Portal (data.nhm.ac.uk) (46 records)
DOI: 10.5284/1103146
title: Images and Report from a Level 3 Analytical Buildings Survey Record at Crow's Nest Farm, Daresbury, Halton, Cheshire 2021

description: This digital archive contains images and a report from a level 2 building recording survey, which was carried out by LP Archaeology at Crow's Nest Farm, Delph Lane, Daresbury, Warrington, WA4 4AW, in 2021. Crow's Nest Farm was formerly a dairy farm and the buildings predominately dated to the late 18th century, with later 19th, 20th and 21st century alteration, extensions and modifications evident. Reused red sandstone dressed blocks encountered across the site and a possible in situ earlier wall suggest the farmstead may have had earlier origins of a potential 16th to 17th century date.
DOI: 10.6084/m9.figshare.20038226
title: Immigration as the main driver of population dynamics in a cryptic cetacean

description: Description of the data files: 'CH_Female_Multi_2004_6events_v3.txt': Capture-recapture multievent data for females; 'CH_Female_Multi_2004_z_init_Nimble.txt': Initial values for latent z states and state at first encounter for females; 'CH_headed_Male_Multi_2004.txt': Capture-recapture multievent data for males; 'CH_headed_Male_Multi_2004_z_init.txt': Initial values for latent z states and state at first encounter for males; 'count_data.RData': Population count data; Model code: 'IPM_10.txt' <br> All files are called in the online supplementary code for running the integrated population model.
DOI: 10.6084/m9.figshare.20038226.v1
title: Immigration as the main driver of population dynamics in a cryptic cetacean

description: Description of the data files: 'CH_Female_Multi_2004_6events_v3.txt': Capture-recapture multievent data for females; 'CH_Female_Multi_2004_z_init_Nimble.txt': Initial values for latent z states and state at first encounter for females; 'CH_headed_Male_Multi_2004.txt': Capture-recapture multievent data for males; 'CH_headed_Male_Multi_2004_z_init.txt': Initial values for latent z states and state at first encounter for males; 'count_data.RData': Population count data; Model code: 'IPM_10.txt' <br> All files are called in the online supplementary code for running the integrated population model.
DOI: 10.6084/m9.figshare.22015040
title: Best fit mn of the Umbria-Marche rivers.xlsx

description: The table collect the best fit m/n ratio of the Umbria-Marche river (central Italy) that has been derived by the Bayesian optimization script of Topotoolbox (Schwanghart & Kuhn, 2010; Schwanghart & Scherler, 2014)
DOI: 10.6084/m9.figshare.22015040.v1
title: Best fit mn of the Umbria-Marche rivers.xlsx

description: The table collect the best fit m/n ratio of the Umbria-Marche river (central Italy) that has been derived by the Bayesian optimization script of Topotoolbox (Schwanghart & Kuhn, 2010; Schwanghart & Scherler, 2014)
DOI: 10.11588/data/jco0e4/pahbdp
title: HeiData_Biphenylene.zip

description: :unav
DOI: 10.5281/zenodo.7610568
title: Photon bound state dynamics from a single artificial atom: Source Data

description: Source Data for figures in main manuscript of <strong>Tomm, N., Mahmoodian, S., et al., <em>Photon bound state dynamics from a single artificial atom</em></strong>.
DOI: 10.5281/zenodo.7610567
title: Photon bound state dynamics from a single artificial atom: Source Data

description: Source Data for figures in main manuscript of <strong>Tomm, N., Mahmoodian, S., et al., <em>Photon bound state dynamics from a single artificial atom</em></strong>.
DOI: 10.23728/b2share.3159b45c78654129a7ebe79964c51c6a
title: Anisotropic solvent self-diffusion gives insight into thermo responsive behavior of polymeric lyotropic liquid crystals
DOI: 10.34740/kaggle/dsv/4158545
title: BD Fish Dataset AsifShakil withBG UpsharpMask
DOI: 10.6084/m9.figshare.21988712.v1
title: Supplementary Material for: Synergistic Toxicities from Multiple Therapies for Synchronous Malignancies

description: Patients may present with multiple malignancies in the setting of particular environmental and occupational exposures. These patients often require combination systemic therapy not yet studied for concurrent use. While toxicities for specific chemotherapies and immunotherapies may be well known, the possibility of exaggerated toxicity due to combination therapy exists and is understudied. Several trials are under way that may shed further light on how combination therapies affect patient toxicity. This case report outlines the unfortunate development of severe edema and rash, refractory to traditional methods of management, from combining immunotherapy and chemotherapy.
DOI: 10.5281/zenodo.7610738
title: Load-bearing hydrogels ionically reinforced through competitive ligand exchanges

description: Fast advances in soft robotics and tissue engineering demand for new soft materials whose mechanical properties can be interchangeably and locally varied, thereby enabling, for example, the design of soft joints within an integral material. Inspired by nature, we introduce a competitive ligand-mediated approach to selectively and interchangeably reinforce metal-coordinated hydrogels. This is achieved by reinforcing carboxylate-containing hydrogels with Fe<sup>3+</sup> ions. Key to achieving a homogeneous, predictable reinforcement of the hydrogels is the presence of weak complexation agents that delay the formation of metal-complexes within the hydrogels, thereby allowing a homogeneous distribution of the metal ions. The resulting metal-reinforced hydrogels show a compressive modulus of up to 2.5 MPa, while being able to withstand pressures as high as 0.6 MPa without appreciable damage. Competitive ligand exchanges offer an additional advantage: they enable non-linear compositional changes that, for example, allow the formation of joints within these hydrogels. These features open up new possibilities to extend the field of use of metal reinforced hydrogels to load-bearing applications that are omnipresent for example in soft robots and actuators.
DOI: 10.5281/zenodo.7610737
title: Load-bearing hydrogels ionically reinforced through competitive ligand exchanges

description: Fast advances in soft robotics and tissue engineering demand for new soft materials whose mechanical properties can be interchangeably and locally varied, thereby enabling, for example, the design of soft joints within an integral material. Inspired by nature, we introduce a competitive ligand-mediated approach to selectively and interchangeably reinforce metal-coordinated hydrogels. This is achieved by reinforcing carboxylate-containing hydrogels with Fe<sup>3+</sup> ions. Key to achieving a homogeneous, predictable reinforcement of the hydrogels is the presence of weak complexation agents that delay the formation of metal-complexes within the hydrogels, thereby allowing a homogeneous distribution of the metal ions. The resulting metal-reinforced hydrogels show a compressive modulus of up to 2.5 MPa, while being able to withstand pressures as high as 0.6 MPa without appreciable damage. Competitive ligand exchanges offer an additional advantage: they enable non-linear compositional changes that, for example, allow the formation of joints within these hydrogels. These features open up new possibilities to extend the field of use of metal reinforced hydrogels to load-bearing applications that are omnipresent for example in soft robots and actuators.
DOI: 10.6084/m9.figshare.22015094.v1
title: Supplementary Material for: Relationship between Eosinophilic and Neutrophilic Inflammation in Chinese Chronic Rhinosinusitis with Nasal Polyps

description: <b><i>Introduction:</i></b> Chronic rhinosinusitis with nasal polyps (CRSwNPs) in China is characterized by a mixed eosinophilic-neutrophilic inflammation, linking to a more heterogeneous clinical phenotype. However, the relationship between eosinophilic and neutrophilic inflammation in Chinese patients with CRSwNP remains largely unknown. We aimed to further characterize the correlation between neutrophils with eosinophils in relation to clinical characters and disease control status after endoscopic sinus surgery (ESS). <b><i>Methods:</i></b> A total of 242 patients were recruited and stratified based on tissue (≥10%) eosinophilia and (≥20/per high-power field) neutrophilia. Clinical characteristics and disease control status were compared between subgroups. Associations between tissue eosinophils and neutrophils were analyzed. <b><i>Results:</i></b> The uncontrolled patients accounted for 41.3%, 41.3%, 17.1%, and 22.2% in subjects with concomitant tissue eosinophilia and neutrophilia (EN-high), isolated eosinophilia (E-high), isolated neutrophilia (N-high), and no eosinophilia and neutrophilia (EN-low), respectively. Positive correlations between tissue eosinophils and neutrophils were observed in patients with CRSwNP as well as in EN-high and N-high subgroups but not in E-high and EN-low subgroups. The EN-high subgroup had higher tissue eosinophil numbers than the other three subgroups. Both EN-high and E-high subgroups had higher rates of uncontrolled subjects than the N-high and EN-low subgroups; however, there was no difference in the rate of uncontrolled subjects between EN-high and E-high subgroups and between N-high and EN-low subgroups. <b><i>Conclusion:</i></b> Tissue neutrophils might have a potential interaction and mutual promotion effect with eosinophils in CRSwNP. However, tissue neutrophilia would not pose significant risk for poor disease control after ESS. Further larger, prospective studies are needed to confirm our findings.
DOI: 10.6084/m9.figshare.17295180
title: Early mobilization in acute stroke phase: a systematic review

description: Early mobilization is defined as out-of-bed activities in acute stroke phase, and has led to improvements in functional capacity and reduction of complications after stroke. This study aimed to investigate the effectiveness and safety of early mobilization in the acute stroke phase. This was a systematic review. We searched for studies with the keywords: “Stroke,” “Early mobilization” and “Functional outcomes.” Data source: NLM, LILACS, MEDLINE, PEDro, and Science Direct. Studies published up to June 2020 were included; (b) study eligibility criteria: clinical trials; (c) participants: stroke patients in the acute phase; (d) interventions: early mobilization; (e) study appraisal: two authors independently assessed the risk of bias, Grading of Recommendations Assessment, Development and Evaluation, and the Oxford Center for Evidence-Based Medicine Levels of Evidence. The safety was evaluated based on related and non-related adverse effects. Altogether, 476 studies were retrieved. After exclusion, seven studies involving 8663 patients were included in the qualitative synthesis. The main activities were elevation of the headboard, sitting, standing, and walking. The most important outcome assessed was the modified Rankin scale score (disability) after 3 months of stroke, and two studies showed that early mobilization improves functional capacity after stroke. the optimal time to start early mobilization is &gt; 24 h of stroke according to hemodynamic stability and safety criteria. The duration of mobilization is recommended between 15 and 45 minutes, divided into one, two, or three times a day. The focus of early mobilization should be on sitting, standing, and walking activity.
DOI: 10.6084/m9.figshare.18009871
title: Stroke self-efficacy questionnaire – Denmark (SSEQ-DK): test–retest of the Danish version

description: In stroke rehabilitation, measurement tools measuring self-efficacy with sound psychometric properties are needed. The Stroke Self-Efficacy Questionnaire (SSEQ) has recently been translated and validated into a Danish version (SSEQ–DK). To evaluate the test–retest reliability of the SSEQ-DK. Fifty people with stroke ≥ 18 years in the sub-acute and chronic phase were included from February 2019 to August 2020. The SSEQ-DK was completed twice; on day 1 and day 7–14. Test–retest reliability of the single items was assessed using weighted Cohen’s kappa and percentage agreement. The activity and self-management scales were assessed by the intraclass correlation coefficient (ICC). Measurement error was assessed by calculating the Smallest Detectable Change (SDC) based on the standard error of measurement. Overall, kappa values showed fair to substantial test–retest reliability of the single items. However, several kappa values were missing as the statistical prerequisites were not present. The percentage agreement ranged from 78% to 94%. Based on the reported confidence interval of the estimated intraclass correlation coefficient, the test–retest reliability of the activity and self-management scales was poor to excellent in all analysis. Ceiling effects appeared in the single items. Conversely, no floor effect was seen. The SSEQ-DK showed good test–retest reliability of the single items based on agreement among a population with stroke in the subacute and chronic phase. Broad ICC confidence intervals bar any firm conclusions concerning the test–retest reliability of the activity and self-management scales. ClinicalTrials.gov NCT03183960. Reg. 15 June 2017.
DOI: 10.6084/m9.figshare.18009871.v1
title: Stroke self-efficacy questionnaire – Denmark (SSEQ-DK): test–retest of the Danish version

description: In stroke rehabilitation, measurement tools measuring self-efficacy with sound psychometric properties are needed. The Stroke Self-Efficacy Questionnaire (SSEQ) has recently been translated and validated into a Danish version (SSEQ–DK). To evaluate the test–retest reliability of the SSEQ-DK. Fifty people with stroke ≥ 18 years in the sub-acute and chronic phase were included from February 2019 to August 2020. The SSEQ-DK was completed twice; on day 1 and day 7–14. Test–retest reliability of the single items was assessed using weighted Cohen’s kappa and percentage agreement. The activity and self-management scales were assessed by the intraclass correlation coefficient (ICC). Measurement error was assessed by calculating the Smallest Detectable Change (SDC) based on the standard error of measurement. Overall, kappa values showed fair to substantial test–retest reliability of the single items. However, several kappa values were missing as the statistical prerequisites were not present. The percentage agreement ranged from 78% to 94%. Based on the reported confidence interval of the estimated intraclass correlation coefficient, the test–retest reliability of the activity and self-management scales was poor to excellent in all analysis. Ceiling effects appeared in the single items. Conversely, no floor effect was seen. The SSEQ-DK showed good test–retest reliability of the single items based on agreement among a population with stroke in the subacute and chronic phase. Broad ICC confidence intervals bar any firm conclusions concerning the test–retest reliability of the activity and self-management scales. ClinicalTrials.gov NCT03183960. Reg. 15 June 2017.
DOI: 10.6084/m9.figshare.22012718
title: Output and results of all GSA

description: Attached are the raw output files and the results of the 3 GSA analysis preformed during this research
DOI: 10.5281/zenodo.7273772
title: Dataset related to article "Invasive IPMN relapse later and more often in lungs in comparison to pancreatic ductal adenocarcinoma"

description: This record contains data related to article “Invasive IPMN relapse later and more often in lungs in comparison to pancreatic ductal adenocarcinoma” <strong>Background: </strong> The different oncological outcomes of invasive intraductal papillary mucinous neoplasm (I-IPMN) and pancreatic ductal adenocarcinoma (PDAC) are debated. This study aimed to compare disease recurrence patterns and histopathological characteristics in patients with resected I-IPMN and PDAC. <strong>Methods: </strong> Consecutive patients undergoing surgical resection for stage I-III I-IPMN or PDAC between 2010 and 2016 were retrospectively analyzed. Patients treated with neoadjuvant therapy or resected for Tis neoplasia were excluded. All surgical specimens were re-staged according to AJCC-8th-edition. <strong>Results: </strong> A total of 330 patients were included, of whom 43 had I-IPMN and 287 had PDAC. Median follow-up time was 26.7 (1.3-92.3) months and estimated median disease-free survival (DFS) was 60.3 months (47.2-73.4) for I-IPMN and 23.8 (19.3-28.2) months for PDAC (p &lt; 0.001). During follow-up, 32.6% of I-IPMN and 67.9% of PDAC patients experienced recurrence (p &lt; 0.001). The sites of first recurrence were the lungs (38.5% vs 13.1%, p = 0.027), liver (28.6% vs 45.0%, p = 0.180) and local (15.4% vs 36.6%, p = 0.101) for I-IPMN and PDAC, respectively. At multivariate analysis, I-IPMN histology remained an independent predictive factor for longer DFS (OR 0.528, CI 95% 0.278-1.000, p = 0.050), regardless of stage or adjuvant chemotherapy. I-IPMN and PDAC differed in rates of neuroinvasion (51.2% vs 97.2%) and positive lymph node status (N+) (46.5% vs 82.7%), especially in patients with lower T status. <strong>Conclusion: </strong> I-IPMN showed a different recurrence pattern compared to PDAC, with a higher lung tropism, and longer DFS. This different biological behavior is associated with lower rates of neuroinvasion and nodal involvement, especially in early-stage disease.