cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.3886/e239340v1
title: Influenza virus induced novel miRNAs regulate the STAT pathway

description: MicroRNAs are essential regulators of gene expression in humans and can control pathogenesis and host-virus interactions. Notably, the role of specific miRNAs during influenza virus infections are still ill-defined. The central goal of this study was to identify novel miRNAs and their target genes in response to influenza virus infections in airway epithelium. Human airway epithelial cells exposed to influenza virus induced several novel miRNAs that were identified using next generation sequencing (NGS) and their target genes by biochemical methods. NGS analysis predicted forty-two RNA sequences as possible miRNAs based on computational algorithms. Expression patterns of these putative miRNAs were further confirmed using RT-PCR in human bronchial epithelial cells (HBEpC) exposed to H1N1, H9N1(1P10) and H9N1 (1WF10) strains of influenza virus. A time course study showed significant downregulation of put-miR-34 in H1N1 and put-miR-35 in H9N1(1P10) infected cells, consistent with the NGS data. Additionally put-miR-34, and put-miR-35 showed a high fold enrichment in argonaute-immunoprecipitation compared to the controls, indicating their ability to form a complex with argonaute protein and RNA induced silencing complex (RISC), a typical mode of action found with miRNAs. Our earlier studies have shown that replication and survival of influenza virus is modulated by certain transcription factors, such as, NF-ĸB. To identify the target(s) of these putative miRNAs, we screened 84 transcription factors that have a role in viral pathogenesis. Cells transfected with mimic of the put-miR-34 showed significant decrease in expression of Signal Transducers and Activators of Transcription 3 (STAT3), and the inhibitor of put-miR-34 showed significant increase in STAT3 expression and its phosphorylation. In addition, put-miR-34 had 76% homology to the untranslated region (UTR) of STAT3. NGS and PCR array data submitted to the Gene Ontology also predicted the role of transcription factors modulated by put-miR-34. Our data suggests that put-miR-34 could be a good target for the antiviral therapy as the hyperactivation or inactivation of STAT3 results in viral disease, as tightly regulated STAT3 function is central to health.
description: Data downloaded 5/20/2025
DOI: 10.3886/e239348
title: Biological effects of inhaled crude oil vapor VI. Altered biogenic amine neurotransmitters and neural protein expression

description: In
 the oil and gas industry, workers are potentially exposed to crude oil 
or crude oil vapor (COV) during upstream (drilling and extraction), 
midstream (transportation and storage), as well as downstream (refining)
 activities. Worker exposure to various fractions of crude oil have 
been linked to mortality, as well as musculoskeletal, respiratory, 
gastrointestinal, circulatory problems, and cancer. During the Gulf of 
Mexico Deepwater Horizon (DWH) oil spill, response workers were exposed 
to a variety of chemical hazards including volatile organic compounds 
(VOCs), polycyclic aromatic hydrocarbons (PAHs), heavy metals, as well 
as components of the oil dispersants employed to disperse the oil. The 
Gulf Long-term Follow-up (GuLF) STUDY had reported that workers involved
 in the cleanup operations experienced adverse hematologic, pulmonary, 
hepatic, and cardiac problems. However, long-term neurological effects 
remain unknown.<br><br>Health Hazard Evaluation (HHE) surveys conducted 
by NIOSH among the cleanup workers identified a variety of health 
effects, including neurological symptoms. Unfortunately, as a 
significant number of response workers who experienced health symptoms 
were exposed to both crude oil and the oil dispersant that was aerially 
sprayed to the contain the spill, the health effects of crude oil 
exposures alone were difficult to discern from these surveys. It is 
here that laboratory-based studies are advantageous as they can provide 
ample health risk information to establish the toxicological potential 
of the various chemical hazards at the workplace. To that end, the 
present work evaluated the neurotoxic risks of COV generated from the 
Macondo well crude oil that was used as a surrogate for the DWH crude 
oil.<br><br>
description: Data downloaded 5/20/2025
DOI: 10.3886/e239348v1
title: Biological effects of inhaled crude oil vapor VI. Altered biogenic amine neurotransmitters and neural protein expression

description: In
 the oil and gas industry, workers are potentially exposed to crude oil 
or crude oil vapor (COV) during upstream (drilling and extraction), 
midstream (transportation and storage), as well as downstream (refining)
 activities. Worker exposure to various fractions of crude oil have 
been linked to mortality, as well as musculoskeletal, respiratory, 
gastrointestinal, circulatory problems, and cancer. During the Gulf of 
Mexico Deepwater Horizon (DWH) oil spill, response workers were exposed 
to a variety of chemical hazards including volatile organic compounds 
(VOCs), polycyclic aromatic hydrocarbons (PAHs), heavy metals, as well 
as components of the oil dispersants employed to disperse the oil. The 
Gulf Long-term Follow-up (GuLF) STUDY had reported that workers involved
 in the cleanup operations experienced adverse hematologic, pulmonary, 
hepatic, and cardiac problems. However, long-term neurological effects 
remain unknown.<br><br>Health Hazard Evaluation (HHE) surveys conducted 
by NIOSH among the cleanup workers identified a variety of health 
effects, including neurological symptoms. Unfortunately, as a 
significant number of response workers who experienced health symptoms 
were exposed to both crude oil and the oil dispersant that was aerially 
sprayed to the contain the spill, the health effects of crude oil 
exposures alone were difficult to discern from these surveys. It is 
here that laboratory-based studies are advantageous as they can provide 
ample health risk information to establish the toxicological potential 
of the various chemical hazards at the workplace. To that end, the 
present work evaluated the neurotoxic risks of COV generated from the 
Macondo well crude oil that was used as a surrogate for the DWH crude 
oil.<br><br>
description: Data downloaded 5/20/2025
DOI: 10.3886/e239347
title: Effects of Welding Fume Exposure on Human Placental Cells

description: As more women join the skilled-trade workforce, the effects of workplace exposures on pregnancy need to be explored. This study aimed to identify the effects of mild-steel (MS) and stainless-steel (SS) welding fume exposures on first-trimester placental trophoblast cells, using the HTR-8/SVneo cell line. MS is primarily composed of Iron (Fe) and Manganese (Mn), while SS also contains chromium (Cr) and nickel (Ni). We found that all three welding fumes had significant effects on cellular viability, and also caused increases in free radical production, while negatively affecting their invasive capabilities. MS was the only sample to cause an increase in production of the pro-inflammatory cytokines IL-6 and IL-8. Our results show that welding fume exposure is in fact cytotoxic to trophoblasts, and understanding how these occupational exposures could impact maternal and fetal health is necessary. Identifying how the varying combinations of heavy metals and other materials present in MS and SS welding fumes, along
description: Data downloaded 5/20/2025
DOI: 10.3886/e239347v1
title: Effects of Welding Fume Exposure on Human Placental Cells

description: As more women join the skilled-trade workforce, the effects of workplace exposures on pregnancy need to be explored. This study aimed to identify the effects of mild-steel (MS) and stainless-steel (SS) welding fume exposures on first-trimester placental trophoblast cells, using the HTR-8/SVneo cell line. MS is primarily composed of Iron (Fe) and Manganese (Mn), while SS also contains chromium (Cr) and nickel (Ni). We found that all three welding fumes had significant effects on cellular viability, and also caused increases in free radical production, while negatively affecting their invasive capabilities. MS was the only sample to cause an increase in production of the pro-inflammatory cytokines IL-6 and IL-8. Our results show that welding fume exposure is in fact cytotoxic to trophoblasts, and understanding how these occupational exposures could impact maternal and fetal health is necessary. Identifying how the varying combinations of heavy metals and other materials present in MS and SS welding fumes, along
description: Data downloaded 5/20/2025
DOI: 10.3886/e239331
title: Multi-Walled Carbon Nanotubes Induce Arachidonate 5-Lipoxygenase Expression and Enhance the Polarization and Function of M1 Macrophages in vitro

description: Fibrogenic carbon nanotubes (CNTs) induce the polarization of M1 and M2 macrophages in mouse lungs. Polarization of the macrophages regulates the production of proinflammatory and pro-resolving lipid mediators (LMs) to mediate acute inflammation and its resolution in a time-dependent manner. Here we examined the molecular mechanism by which multi-walled CNTs (MWCNTs, Mitsui-7) induce M1 polarization in vitro. Treatment of murine macrophages (J774A.1) with Mitsui-7 MWCNTs increased the expression of Alox5 mRNA and protein in a concentration- and time-dependent manner. The MWCNTs induced the expression of CD68, and that induction persisted for up to 3 days post-exposure. The expression and activity of inducible nitric oxide synthase, an intracellular marker of M1, were increased by MWCNTs. Consistent with M1 polarization, the MWCNTs induced the production and secretion of proinflammatory cytokines tumor necrosis factor-α and interleukin-1β, and proinflammatory LMs leukotriene B4 (LTB4) and prostaglandin E2 (PGE2). The cell-free media from MWCNT-polarized macrophages induced the migration of neutrophilic cells (differentiated from HL-60), which was blocked by Acebilustat, a specific leukotriene A4 hydrolase inhibitor, or LY239111, an LTB4 receptor antagonist, but not NS-398, a cyclooxygenase 2 inhibitor, revealing LTB4 as a major mediator of neutrophil chemotaxis from MWCNT-polarized macrophages. Knockdown of Alox5 using specific small hairpin-RNA suppressed MWCNT-induced M1 polarization, LTB4 secretion, and migration of neutrophils. Taken together, these findings demonstrate the polarization of M1 macrophages by Mitsui-7 MWCNTs in vitro and that induction of Alox5 is an important mechanism by which the MWCNTs promote proinflammatory responses by boosting M1 polarization and production of proinflammatory LMs.
description: Data downloaded 5/20/2025
DOI: 10.3886/e239331v1
title: Multi-Walled Carbon Nanotubes Induce Arachidonate 5-Lipoxygenase Expression and Enhance the Polarization and Function of M1 Macrophages in vitro

description: Fibrogenic carbon nanotubes (CNTs) induce the polarization of M1 and M2 macrophages in mouse lungs. Polarization of the macrophages regulates the production of proinflammatory and pro-resolving lipid mediators (LMs) to mediate acute inflammation and its resolution in a time-dependent manner. Here we examined the molecular mechanism by which multi-walled CNTs (MWCNTs, Mitsui-7) induce M1 polarization in vitro. Treatment of murine macrophages (J774A.1) with Mitsui-7 MWCNTs increased the expression of Alox5 mRNA and protein in a concentration- and time-dependent manner. The MWCNTs induced the expression of CD68, and that induction persisted for up to 3 days post-exposure. The expression and activity of inducible nitric oxide synthase, an intracellular marker of M1, were increased by MWCNTs. Consistent with M1 polarization, the MWCNTs induced the production and secretion of proinflammatory cytokines tumor necrosis factor-α and interleukin-1β, and proinflammatory LMs leukotriene B4 (LTB4) and prostaglandin E2 (PGE2). The cell-free media from MWCNT-polarized macrophages induced the migration of neutrophilic cells (differentiated from HL-60), which was blocked by Acebilustat, a specific leukotriene A4 hydrolase inhibitor, or LY239111, an LTB4 receptor antagonist, but not NS-398, a cyclooxygenase 2 inhibitor, revealing LTB4 as a major mediator of neutrophil chemotaxis from MWCNT-polarized macrophages. Knockdown of Alox5 using specific small hairpin-RNA suppressed MWCNT-induced M1 polarization, LTB4 secretion, and migration of neutrophils. Taken together, these findings demonstrate the polarization of M1 macrophages by Mitsui-7 MWCNTs in vitro and that induction of Alox5 is an important mechanism by which the MWCNTs promote proinflammatory responses by boosting M1 polarization and production of proinflammatory LMs.
description: Data downloaded 5/20/2025
DOI: 10.15468/dl.pv96dv
title: Occurrence Download

description: A dataset listing the 217487 species recorded in GBIF matching the query:
{
 "and" : [
 "Geometry POLYGON((-44.338 -23.021,0 -23.021,0 0,-44.338 0,-44.338 -23.021))",
 "OccurrenceStatus is Present"
 ]
}

 The dataset's 217487 records were derived from 2518 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0005504-251025141854904/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.c8ynm7
title: Occurrence Download

description: A dataset containing 5086 species occurrences available in GBIF matching the query:
{
 "DatasetKey" : [
 "is Occurrence of the reptiles in the Volga River basin (Russia)"
 ]
}

 The dataset includes 5086 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0062393-250920141307145/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.fbukpt
title: Occurrence Download

description: A dataset containing 3449 species occurrences available in GBIF matching the query:
{
 "and" : [
 "DatasetKey is one of (Moscow University Herbarium (MW), MHA Herbarium: collections of vascular plants, IRKU Herbarium: collections of vascular plants, TUL Herbarium: Tula Oblast collections of vascular plants, TULGU Herbarium: Tula Oblast collections of vascular plants, KUZ Herbarium: collections of vascular plants, MAG Herbarium: collections of vascular plants, KULPOL Herbarium: Tula Oblast collections of vascular plants, TKM Herbarium: Tula Oblast collections of vascular plants)",
 "Issue is one of (Taxon match none, Taxon match higher rank)",
 "OccurrenceStatus is Present"
 ]
}

 The dataset includes 3449 records from 8 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0033109-220831081235567/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.ztwd7e
title: Occurrence Download

description: A dataset containing 39 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Sciades sona (Hamilton, 1822)"
 ]
}

 The dataset includes 39 records from 11 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0033152-220831081235567/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.spx26x
title: Occurrence Download

description: A dataset containing 606 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Cebidichthys violaceus (Girard, 1854)"
 ]
}

 The dataset includes 606 records from 42 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0033156-220831081235567/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.34c25u
title: Occurrence Download

description: A dataset containing 648 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Brachirus niger (Macleay, 1880)"
 ]
}

 The dataset includes 648 records from 22 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0033176-220831081235567/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.36ungs
title: Occurrence Download

description: A dataset containing 1021 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Serranus psittacinus Valenciennes, 1846"
 ]
}

 The dataset includes 1021 records from 44 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0033159-220831081235567/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.tpy9xx
title: Occurrence Download

description: A dataset containing 1104 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Lepidotrigla papilio (Cuvier, 1829)"
 ]
}

 The dataset includes 1104 records from 28 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0033160-220831081235567/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.j6e6pq
title: Occurrence Download

description: A dataset containing 14433 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Genista germanica L.",
 "HasCoordinate is true"
 ]
}

 The dataset includes 14433 records from 151 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0033447-220831081235567/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.yp8b9r
title: Occurrence Download

description: A dataset containing 2337 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Cantherhines dumerilii (Hollard, 1854)"
 ]
}

 The dataset includes 2337 records from 84 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0033142-220831081235567/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.dr3pa7
title: Occurrence Download

description: A dataset listing the 3482107 species recorded in GBIF matching the query:
{ }

 The dataset's 3482107 records were derived from 50590 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0004950-220831081235567/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.ulupfy
title: Occurrence Download

description: A dataset containing 8 species occurrences available in GBIF matching the query:
{
 "DatasetKey" : [
 "is (Table 1) Proportion of Toxoplasma gondii seropositive arctic foxes (Alopex lagopus) by age group and geographic area"
 ]
}

 The dataset includes 8 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0006171-160311141623029/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.ha8gkp
title: Occurrence Download

description: A dataset containing 1203 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Rhynchosia sublobata (Schumach.) Meikle",
 "Continent is Africa"
 ]
}

 The dataset includes 1203 records from 68 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0005321-250402121839773/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.87e2cs
title: Occurrence Download

description: A dataset containing 125159 species occurrences available in GBIF matching the query:
{
 "Geometry" : [
 "MULTIPOLYGON(((5.598907470703125 43.481822852999905,5.511016845703125 43.509717009288075,5.400552749633789 43.51127322324609,5.412139892578125 43.54257572246922,5.4547119140625 43.563476493226595,5.480804443359375 43.61122246320032,5.483551025390625 43.6499881760459,5.503549575805664 43.66644361490711,5.598907470703125 43.66985832954972,5.69091796875 43.70362249839005,5.763702392578124 43.661911057260674,5.79254150390625 43.625141236940564,5.804901123046875 43.601278509333646,5.799407958984375 43.5734266934657,5.76507568359375 43.52565074189047,5.71563720703125 43.52166770320007,5.598907470703125 43.481822852999905)))"
 ]
}

 The dataset includes 125159 records from 387 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0011376-210819072339941/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.arc9uc
title: Occurrence Download

description: A dataset containing 1285 species occurrences available in GBIF matching the query:
{
 "and" : [
 {
 "or" : [
 "BasisOfRecord is Specimen",
 "BasisOfRecord is Material sample"
 ]
 },
 "TaxonKey is Pygocentrus nattereri Kner, 1858"
 ]
}

 The dataset includes 1285 records from 68 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0009177-210819072339941/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.effpx0
title: Occurrence Download

description: A dataset containing 687 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Cyclopes didactylus (Linnaeus, 1758)"
 ]
}

 The dataset includes 687 records from 73 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0012605-181108115102211/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.ta6347
title: Occurrence Download

description: A dataset containing 100 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Phocoena phocoena (Linnaeus, 1758)",
 "HasGeospatialIssue is true",
 "HasCoordinate is true"
 ]
}

 The dataset includes 100 records from 16 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0014453-210819072339941/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.cx2g7f
title: Occurrence Download

description: A dataset containing 4451 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is United States of America",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 "TaxonKey is Hypophthalmichthys molitrix (Valenciennes, 1844)"
 ]
}

 The dataset includes 4451 records from 17 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0009178-210819072339941/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.n4xaj1
title: Occurrence Download

description: A dataset containing 3 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Nepenthes hemsleyana Macfarl."
 ]
}

 The dataset includes 3 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0012606-181108115102211/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.qte7sd
title: Occurrence Download

description: A dataset containing 52208 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Juncus compressus Jacq."
 ]
}

 The dataset includes 52208 records from 353 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0214065-200613084148143/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.