cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.25345/c51v5bs56
title: MassIVE MSV000098736 - Integrated omics identifies alleviators of cellular senescence induced by automotive brake-derived PM2.5 in macrophages
title: The toxicity of automobile-derived particulate matter with an aerodynamic diameter of less than 2.5 um (PM2.5), particularly from non-exhaust sources such as brake wear, remains largely unexplored. Notably, brake wear particles are generated in greater quantities than exhaust-derived PM2.5 and have recently been designated as new regulatory targets. However, their biological impact and underlying molecular mechanisms remain elusive. We employed a multidisciplinary approach to investigate the toxicological effects of both diesel exhaust and non-exhaust PM2.5, derived from non-asbestos organic (NAO) and low-metallic (LM) brake pads, in the THP-1 human monocytic leukaemia cell line. Cellular ultrastructural changes were assessed using transmission electron microscopy, while biological responses were analysed through molecular biology techniques. Additionally, we conducted transcriptomic profiling using next-generation sequencing and proteomic analysis via LC-MS/MS. An integrated omics network was constructed to elucidate key molecular pathways and identify druggable targets to mitigate PM2.5-induced toxicity. Exposure to either exhaust or non-exhaust PM2.5 for 24 hours reduced THP-1 cell viability by approximately 10% at concentrations &gt;50 ug/mL and significantly increased intracellular reactive oxygen species (ROS) production. Lysosomal swelling and accumulation of PM2.5 particles within lysosomes were observed, leading to impaired lysosomal function and disrupted autophagic flux. Transcriptomic analysis revealed significant enrichment in pathways related to lysosomal dysfunction, autophagy inhibition, G1 cell cycle arrest, and cellular senescence. Proteomic analysis confirmed these findings, supporting a senescent phenotype in PM2.5-exposed cells, as evidenced by elevated senescence-associated b-galactosidase activity. Integrated omics network analysis identified key regulatory genes and proteins associated with PM2.5-induced senescence. Drug screening based on network topology highlighted tretinoin, resveratrol, and rapamycin as top candidates, all of which effectively attenuated the senescent phenotype in vitro. Our study demonstrates that both exhaust and non-exhaust automobile-derived PM2.5 induce cellular toxicity via lysosomal dysfunction and promote a senescence-like phenotype in THP-1 macrophages. Through comprehensive transcriptomic and proteomic integration, we identified critical molecular drivers of this phenotype and validated pharmacological interventions. These findings provide a deeper mechanistic understanding of PM2.5-induced toxicity and offer valuable insights for future regulatory strategies aimed at mitigating public health risks associated with traffic-related air pollution.
DOI: 10.15468/dl.44p4cu
title: Occurrence Download

description: A dataset containing 283 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Megachile gravita"
 ]
}

 The dataset includes 283 records from 8 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0016695-250802193616735/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.21233/n39063
title: Site 6 (Heide unpublished) pollen surface sample dataset

description: Raw data for the Site 6 (Heide unpublished) pollen surface sample dataset submitted to the Neotoma Paleoecology Database. Data is available through the landing page in JSON format. The landing page referenced by the DOI also contains links to publications and a map-based viewer for the dataset. The Neotoma Paleoecology Database maintains a homepage at https://www.neotomadb.org.
DOI: 10.21233/n3592f
title: Site 7 (Heide unpublished) pollen surface sample dataset

description: Raw data for the Site 7 (Heide unpublished) pollen surface sample dataset submitted to the Neotoma Paleoecology Database. Data is available through the landing page in JSON format. The landing page referenced by the DOI also contains links to publications and a map-based viewer for the dataset. The Neotoma Paleoecology Database maintains a homepage at https://www.neotomadb.org.
DOI: 10.15468/dl.cd6qtv
title: Occurrence Download

description: A dataset containing 64 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Hemigrammus parana)",
 "BasisOfRecord is one of (Specimen, Literature Occurrence, Human Observation, Observation)",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "Year is greater than or equal to 1991",
 "Year is less than or equal to 2025"
 ]
}

 The dataset includes 64 records from 9 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0016696-250802193616735/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.21233/n31h0h
title: Site 8 (Heide unpublished) pollen surface sample dataset

description: Raw data for the Site 8 (Heide unpublished) pollen surface sample dataset submitted to the Neotoma Paleoecology Database. Data is available through the landing page in JSON format. The landing page referenced by the DOI also contains links to publications and a map-based viewer for the dataset. The Neotoma Paleoecology Database maintains a homepage at https://www.neotomadb.org.
DOI: 10.21233/n3gt79
title: Site 9 (Heide unpublished) pollen surface sample dataset

description: Raw data for the Site 9 (Heide unpublished) pollen surface sample dataset submitted to the Neotoma Paleoecology Database. Data is available through the landing page in JSON format. The landing page referenced by the DOI also contains links to publications and a map-based viewer for the dataset. The Neotoma Paleoecology Database maintains a homepage at https://www.neotomadb.org.
DOI: 10.15468/dl.z7x9wh
title: Occurrence Download

description: A dataset containing 148 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Eviota lachdeberei"
 ]
}

 The dataset includes 148 records from 24 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0016698-250802193616735/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.n6qzgk
title: Occurrence Download

description: A dataset containing 313 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Calycanthus floridus glaucus)",
 "HasCoordinate is true",
 "HasGeospatialIssue is false"
 ]
}

 The dataset includes 313 records from 55 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0016697-250802193616735/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.21233/n3c44b
title: Site 10 (Heide unpublished) pollen surface sample dataset

description: Raw data for the Site 10 (Heide unpublished) pollen surface sample dataset submitted to the Neotoma Paleoecology Database. Data is available through the landing page in JSON format. The landing page referenced by the DOI also contains links to publications and a map-based viewer for the dataset. The Neotoma Paleoecology Database maintains a homepage at https://www.neotomadb.org.
DOI: 10.15468/dl.7gk73q
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "HasGeospatialIssue is false",
 "HasCoordinate is true",
 "OccurrenceStatus is Present",
 "BasisOfRecord is one of (Human Observation, Machine Observation, Occurrence evidence, Observation)",
 "TaxonKey is one of (Semnopithecus entellus)",
 "Country is one of (American Samoa, Australia, Christmas Island, Cocos (Keeling) Islands, Cook Islands, Fiji, French Polynesia, Guam, Heard Island and McDonald Islands, Kiribati, Marshall Islands, Micronesia (Federated States of), Nauru, New Caledonia, New Zealand, Niue, Norfolk Island, Northern Mariana Islands, Palau, Papua New Guinea, Pitcairn, Samoa, Solomon Islands, Tokelau, Tonga, Tuvalu, United States Minor Outlying Islands, Vanuatu, Wallis and Futuna)"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0016699-250802193616735/datasets/export for details.
DOI: 10.21233/n37b11
title: Site 11 (Heide unpublished) pollen surface sample dataset

description: Raw data for the Site 11 (Heide unpublished) pollen surface sample dataset submitted to the Neotoma Paleoecology Database. Data is available through the landing page in JSON format. The landing page referenced by the DOI also contains links to publications and a map-based viewer for the dataset. The Neotoma Paleoecology Database maintains a homepage at https://www.neotomadb.org.
DOI: 10.21233/n33m9k
title: Lantern Hill Pond pollen surface sample dataset

description: Raw data for the Lantern Hill Pond pollen surface sample dataset submitted to the Neotoma Paleoecology Database. Data is available through the landing page in JSON format. The landing page referenced by the DOI also contains links to publications and a map-based viewer for the dataset. The Neotoma Paleoecology Database maintains a homepage at https://www.neotomadb.org.
DOI: 10.21233/n3cs8d
title: Lac Knob pollen surface sample dataset

description: Raw data for the Lac Knob pollen surface sample dataset submitted to the Neotoma Paleoecology Database. Data is available through the landing page in JSON format. The landing page referenced by the DOI also contains links to publications and a map-based viewer for the dataset. The Neotoma Paleoecology Database maintains a homepage at https://www.neotomadb.org.
DOI: 10.15468/dl.58r88q
title: Occurrence Download

description: A dataset containing 248 species occurrences available in GBIF matching the query:
{
 "and" : [
 "OccurrenceStatus is Present",
 "TaxonKey is Sclerocactus cloverae"
 ]
}

 The dataset includes 248 records from 13 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0016700-250802193616735/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.21233/n3805d
title: Kollioksak Lake pollen dataset

description: Raw data for the Kollioksak Lake pollen dataset submitted to the Neotoma Paleoecology Database. Data is available through the landing page in JSON format. The landing page referenced by the DOI also contains links to publications and a map-based viewer for the dataset. The Neotoma Paleoecology Database maintains a homepage at https://www.neotomadb.org.
DOI: 10.21233/n3493h
title: Berelyekh River pollen dataset

description: Raw data for the Berelyekh River pollen dataset submitted to the Neotoma Paleoecology Database. Data is available through the landing page in JSON format. The landing page referenced by the DOI also contains links to publications and a map-based viewer for the dataset. The Neotoma Paleoecology Database maintains a homepage at https://www.neotomadb.org.
DOI: 10.15468/dl.9ebtag
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "HasGeospatialIssue is false",
 "HasCoordinate is true",
 "OccurrenceStatus is Present",
 "BasisOfRecord is one of (Human Observation, Machine Observation, Occurrence evidence, Observation)",
 "TaxonKey is one of (Semnopithecus entellus)",
 "Country is one of (Åland Islands, Albania, Andorra, Austria, Belarus, Belgium, Bosnia and Herzegovina, Bulgaria, Croatia, Czechia, Denmark, Estonia, Faroe Islands, Finland, France, Germany, Gibraltar, Greece, Guernsey, Holy See, Hungary, Iceland, Ireland, Isle of Man, Italy, Jersey, Latvia, Liechtenstein, Lithuania, Luxembourg, Malta, Moldova, Republic of, Monaco, Montenegro, Netherlands, North Macedonia, Norway, Poland, Portugal, Romania, Russian Federation, San Marino, Serbia, Slovakia, Slovenia, Spain, Svalbard and Jan Mayen, Sweden, Switzerland, Ukraine, United Kingdom of Great Britain and Northern Ireland)"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0016701-250802193616735/datasets/export for details.
DOI: 10.21233/n30h06
title: Komaritsa Peat Exposure pollen dataset

description: Raw data for the Komaritsa Peat Exposure pollen dataset submitted to the Neotoma Paleoecology Database. Data is available through the landing page in JSON format. The landing page referenced by the DOI also contains links to publications and a map-based viewer for the dataset. The Neotoma Paleoecology Database maintains a homepage at https://www.neotomadb.org.
DOI: 10.15468/dl.u58v6q
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "HasGeospatialIssue is false",
 "HasCoordinate is true",
 "OccurrenceStatus is Present",
 "BasisOfRecord is one of (Human Observation, Machine Observation, Occurrence evidence, Observation)",
 "TaxonKey is one of (Semnopithecus entellus)",
 "Country is one of (Algeria, Angola, Benin, Botswana, British Indian Ocean Territory, Burkina Faso, Burundi, Cabo Verde, Cameroon, Central African Republic, Chad, Comoros, Congo, Congo, Democratic Republic of the, Côte d’Ivoire, Djibouti, Egypt, Equatorial Guinea, Eritrea, Eswatini, Ethiopia, French Southern Territories, Gabon, Gambia, Ghana, Guinea, Guinea-Bissau, Kenya, Lesotho, Liberia, Libya, Madagascar, Malawi, Mali, Mauritania, Mauritius, Mayotte, Morocco, Mozambique, Namibia, Niger, Nigeria, Réunion, Rwanda, Saint Helena, Ascension and Tristan da Cunha, Sao Tome and Principe, Senegal, Seychelles, Sierra Leone, Somalia, South Africa, South Sudan, Sudan, Tanzania, United Republic of, Togo, Tunisia, Uganda, Western Sahara, Zambia, Zimbabwe)"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0016702-250802193616735/datasets/export for details.
DOI: 10.21233/n3ft70
title: Konergino Exposure pollen dataset

description: Raw data for the Konergino Exposure pollen dataset submitted to the Neotoma Paleoecology Database. Data is available through the landing page in JSON format. The landing page referenced by the DOI also contains links to publications and a map-based viewer for the dataset. The Neotoma Paleoecology Database maintains a homepage at https://www.neotomadb.org.
DOI: 10.15468/dl.uxddew
title: Occurrence Download

description: A dataset containing 5 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Brachiaria mutica",
 "Country is Guyana",
 "HasCoordinate is true"
 ]
}

 The dataset includes 5 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0016704-250802193616735/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.czrsq7
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Brachiaria mutica",
 "Country is Haiti",
 "HasCoordinate is true"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0016706-250802193616735/datasets/export for details.
DOI: 10.15468/dl.974gnw
title: Occurrence Download

description: A dataset containing 282883 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Nucifraga columbiana)",
 "HasCoordinate is true",
 "OccurrenceStatus is Present",
 "License is one of (CC-BY 4.0, CC0 1.0)"
 ]
}

 The dataset includes 282883 records from 60 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0016679-250802193616735/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.21233/n3b441
title: Gulf of Kosmodem'yanskaya-1 Exposure 5706 pollen dataset

description: Raw data for the Gulf of Kosmodem'yanskaya-1 Exposure 5706 pollen dataset submitted to the Neotoma Paleoecology Database. Data is available through the landing page in JSON format. The landing page referenced by the DOI also contains links to publications and a map-based viewer for the dataset. The Neotoma Paleoecology Database maintains a homepage at https://www.neotomadb.org.
DOI: 10.21233/n36b23
title: Gulf of Kosmodem'yanskaya-2 Exposure 5705 pollen dataset

description: Raw data for the Gulf of Kosmodem'yanskaya-2 Exposure 5705 pollen dataset submitted to the Neotoma Paleoecology Database. Data is available through the landing page in JSON format. The landing page referenced by the DOI also contains links to publications and a map-based viewer for the dataset. The Neotoma Paleoecology Database maintains a homepage at https://www.neotomadb.org.
DOI: 10.21233/n32m98
title: Gulf of Kosmodem'yanskaya-3 Exposure 5815 pollen dataset

description: Raw data for the Gulf of Kosmodem'yanskaya-3 Exposure 5815 pollen dataset submitted to the Neotoma Paleoecology Database. Data is available through the landing page in JSON format. The landing page referenced by the DOI also contains links to publications and a map-based viewer for the dataset. The Neotoma Paleoecology Database maintains a homepage at https://www.neotomadb.org.
DOI: 10.21233/n3bs83
title: Kotiranta Lake pollen dataset

description: Raw data for the Kotiranta Lake pollen dataset submitted to the Neotoma Paleoecology Database. Data is available through the landing page in JSON format. The landing page referenced by the DOI also contains links to publications and a map-based viewer for the dataset. The Neotoma Paleoecology Database maintains a homepage at https://www.neotomadb.org.
DOI: 10.21233/n3734r
title: Kotyrkol' Peat Bog pollen dataset

description: Raw data for the Kotyrkol' Peat Bog pollen dataset submitted to the Neotoma Paleoecology Database. Data is available through the landing page in JSON format. The landing page referenced by the DOI also contains links to publications and a map-based viewer for the dataset. The Neotoma Paleoecology Database maintains a homepage at https://www.neotomadb.org.
DOI: 10.21233/n33936
title: Krasivoye Exposure pollen dataset

description: Raw data for the Krasivoye Exposure pollen dataset submitted to the Neotoma Paleoecology Database. Data is available through the landing page in JSON format. The landing page referenced by the DOI also contains links to publications and a map-based viewer for the dataset. The Neotoma Paleoecology Database maintains a homepage at https://www.neotomadb.org.
DOI: 10.15468/dl.enb3j4
title: Occurrence Download

description: A dataset containing 8 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Microglanis nigripinnis)",
 "BasisOfRecord is one of (Specimen, Literature Occurrence, Human Observation, Observation)",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "Year is greater than or equal to 1991",
 "Year is less than or equal to 2025"
 ]
}

 The dataset includes 8 records from 3 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0016707-250802193616735/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.h7w8b2
title: Occurrence Download

description: A dataset containing 184 species occurrences available in GBIF matching the query:
{
 "and" : [
 "BasisOfRecord is one of (Human Observation, Specimen, Living Specimen, Occurrence evidence)",
 "Country is Colombia",
 "DatasetKey is one of (Tropicos MO Specimen Data, Inventario de epífitas sembradas en el Bosque Renace ubicado en Soacha, Cundinamarca, Harvard University Herbaria: All Records, Royal Botanic Gardens, Kew - Herbarium Specimens, Tropicos Specimens Non-MO, Herbario Pontificia Universidad Javeriana, Herbario Nacional Colombiano (COL), iNaturalist Research-grade Observations, Herbario Universidad de Antioquia (HUA), Colección general del plantas vasculares del Herbario JBB, Field Museum of Natural History (Botany) Seed Plant Collection, Herbario Universidad de Caldas - FAUC, ICN - Universidad Nacional de Colombia, General Herbarium – Cryptogamy & Phanerogamy (CJBG-G) of Conservatoire et Jardin botaniques de Genève, Colección Herbario Federico Medem Bogotá - FMB, Riqueza de orquídeas en tres Parques Naturales Regionales de la jurisdicción Norte del departamento del Huila, Colombia, Monocotiledóneas del cerro Tacarcuna-Chocó, en el marco del proyecto Colombia BIO 2017, Flora del Nororiente Colombiano: Colecciones del Herbario Regional Catatumbo Sarare, The New York Botanical Garden Herbarium (NY))",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "PublishingOrg is one of (f442f96e-2017-4cf5-b19f-1f3320ae7577, eac88d99-9f6c-4031-8fc4-8088f0e0dfe7, 0e2f2e28-7790-4c82-b8fb-6ef7b4c764e2, 28eb1a3f-1c15-4a95-931a-4af90ecb574d, cccff716-2694-4209-9f9e-2f7a484465a0, eace4687-50e8-4f9a-829b-29ff8ff1fa8b, 7b8aff00-a9f8-11d8-944b-b8a03c50a862, 90fd6680-349f-11d8-aa2d-b8a03c50a862, f7f9717e-9e50-4a00-a30f-7b134390a566, 9661d20d-86b6-4485-8948-f3c86b022fa7)",
 "TaxonKey is Restrepia"
 ]
}

 The dataset includes 184 records from 12 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0016708-250802193616735/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.21233/n3jm9m
title: Kresta Gulf Exposure pollen dataset

description: Raw data for the Kresta Gulf Exposure pollen dataset submitted to the Neotoma Paleoecology Database. Data is available through the landing page in JSON format. The landing page referenced by the DOI also contains links to publications and a map-based viewer for the dataset. The Neotoma Paleoecology Database maintains a homepage at https://www.neotomadb.org.
DOI: 10.15468/dl.sbsckg
title: Occurrence Download

description: A dataset containing 308148 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Nucifraga caryocatactes)",
 "HasCoordinate is true",
 "OccurrenceStatus is Present",
 "License is one of (CC-BY 4.0, CC0 1.0)"
 ]
}

 The dataset includes 308148 records from 323 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0016678-250802193616735/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.eje2me
title: Occurrence Download

description: A dataset containing 1 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is BOLD:AAE6712"
 ]
}

 The dataset includes 1 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0016709-250802193616735/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.21233/n3dx6b
title: Kryzewinski Lake pollen dataset

description: Raw data for the Kryzewinski Lake pollen dataset submitted to the Neotoma Paleoecology Database. Data is available through the landing page in JSON format. The landing page referenced by the DOI also contains links to publications and a map-based viewer for the dataset. The Neotoma Paleoecology Database maintains a homepage at https://www.neotomadb.org.
DOI: 10.15468/dl.kkzmdn
title: Occurrence Download

description: A dataset containing 2303 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Calycanthus occidentalis)",
 "HasCoordinate is true",
 "HasGeospatialIssue is false"
 ]
}

 The dataset includes 2303 records from 77 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0016710-250802193616735/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.