cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.3082987
title: Randomised controlled trial of a home-based physical activity intervention in breast cancer survivors

description: <strong>Randomised controlled trial of a home-based physical activity intervention in breast cancer survivors</strong> <b>ABSTRACT</b> <b>Background: </b>To improve adherence to physical activity (PA), behavioural support in the form of behavioural change counselling may be necessary. However, limited evidence of the<b> </b>effectiveness of home-based PA combined with counselling in breast cancer patients exists.<b> </b>The aim of this current randomised controlled trial with a parallel group design was to<b> </b>evaluate the effectiveness of a home-based PA intervention on PA levels, anthropometric<b> </b>measures, health-related quality of life (HRQoL), and blood biomarkers in breast cancer<b> </b>survivors. <b>Methods: </b>Eighty post-adjuvant therapy invasive breast cancer patients (age=53.6±9.4yrs;<b> </b>height=161.2±6.8cm; mass=68.7±10.5kg) were randomly allocated to a six-month home based PA intervention or usual care. The intervention group received face-to-face and<b> </b>telephone PA counselling aimed at encouraging the achievement of current recommended<b> </b>PA guidelines. All patients were evaluated for our primary outcome, PA (International PA<b> </b>Questionnaire) and secondary outcomes, mass, BMI, body fat %, HRQoL, insulin resistance,<b> </b>triglycerides (TG) and total (TC), high-density lipoprotein (HDL-C) and low-density lipoprotein<b> </b>(LDL-C) cholesterol were assessed at baseline and at 6-months. <b>Results: </b>On the basis of linear mixed-model analyses adjusted for baseline values<b> </b>performed on 40 patients in each group, total, leisure and vigorous PA significantly<b> </b>increased from baseline to post-intervention in the intervention compared to usual care<b> </b>(between-group differences, 578.5 MET-min・wk<sup>-1</sup>, p=.024, 382.2 MET-min・wk<sup>-1</sup>, p=.010, and<b> </b>264.1 MET-min・wk<sup>-1</sup>, p=.007, respectively). Both body mass and BMI decreased significantly<b> </b>in the intervention compared to usual care (between-group differences, -1.6 kg, p=.040, and<b> </b>-.6 kg/m<sup>2</sup>, p=.020, respectively). Of the HRQoL variables, FACT-Breast, Trial Outcome<b> </b>Index, functional wellbeing, and breast cancer subscale improved significantly in the PA<b> </b>group compared to the usual care group (between-group differences, 5.1, p<i>=</i>.024; 5.6,<b> </b>p=.001; 1.9 p=.025; and 2.8, p<i>=</i>.007, respectively). Finally, TC and LDL-C was significantly<b> </b>reduced in the PA group compared to the usual care group (between-group differences, -.38<b> </b>mmol・L<sup>-1</sup>, p<i>=</i>.001; and -.3 mmol・L<sup>-1</sup>, p<i>=</i>.023, respectively).<b>Conclusions: </b>We found that home-based PA resulted in significant albeit small to moderate<b> </b>improvements in self-reported PA, mass, BMI, breast cancer specific HRQoL, and TC and<b> </b>LDL-C compared with usual care. <br><br><br>
DOI: 10.6084/m9.figshare.3083047
title: Characterization of a new species in the genus <i>Didymosphenia</i> and of <i>Cymbella janischii</i> (Bacillariophyta) from Connecticut, USA

description: Two non-native stalk-forming diatoms that were recently observed in the West Branch of the Farmington River, a tributary of the Connecticut River in Connecticut (USA), are characterized morphologically and barcode marker sequences were obtained for each of them. <i>Cymbella janischii</i>, the dominant stalk-forming species during the summer of 2012, previously had not been found in the northeastern USA. Samples of <i>C. janischii</i> were examined microscopically and used to obtain four sequences of the barcode marker, the V4 region of the 18S rDNA gene. Phylogenetic analysis indicated that the four independent sequences of <i>C. janischii</i> were distinct from, but most closely related to, published sequences of <i>C. janischii</i> from Idaho and <i>C. mexicana</i> from Texas, USA. A second non-native stalk-producing diatom, resembling <i>Didymosphenia geminata</i>, was found in November 2012 – June 2013 and first reported as <i>Didymosphenia</i> sp. Over this period, the observed cells had a compressed morphology and were consistently small compared with <i>D. geminata</i>. Sequences of the V4 region, obtained from three independent direct polymerase chain reactions (PCR) of single cells isolated from the Connecticut samples, indicated a close relationship to three published sequences of <i>D. geminata</i> from Italy, New Zealand and the USA, and to <i>D. siberica</i> and <i>D. dentata</i> from Russia. Frustules of the cells used in the PCR reactions were recovered and examined using scanning electron microscopy, providing a direct link between the observed morphology and sequence data. The morphology of the novel Connecticut <i>Didymosphenia</i> taxon was compared with that of other <i>Didymosphenia</i> taxa, being most similar to <i>D. pumila</i>, <i>D. laticollis</i>, <i>D. grunowii</i> and smaller cells of <i>D. geminata. Didymosphenia</i> sp. had a triundulate morphology with a consistent length of 40–60 µm. Given the unique morphological features of this diatom, it is proposed as a new species, <i>Didymosphenia hullii</i> Khan-Bureau, sp. nov.
DOI: 10.6084/m9.figshare.3082987.v1
title: Randomised controlled trial of a home-based physical activity intervention in breast cancer survivors

description: <strong>Randomised controlled trial of a home-based physical activity intervention in breast cancer survivors</strong> <b>ABSTRACT</b> <b>Background: </b>To improve adherence to physical activity (PA), behavioural support in the form of behavioural change counselling may be necessary. However, limited evidence of the<b> </b>effectiveness of home-based PA combined with counselling in breast cancer patients exists.<b> </b>The aim of this current randomised controlled trial with a parallel group design was to<b> </b>evaluate the effectiveness of a home-based PA intervention on PA levels, anthropometric<b> </b>measures, health-related quality of life (HRQoL), and blood biomarkers in breast cancer<b> </b>survivors. <b>Methods: </b>Eighty post-adjuvant therapy invasive breast cancer patients (age=53.6±9.4yrs;<b> </b>height=161.2±6.8cm; mass=68.7±10.5kg) were randomly allocated to a six-month home based PA intervention or usual care. The intervention group received face-to-face and<b> </b>telephone PA counselling aimed at encouraging the achievement of current recommended<b> </b>PA guidelines. All patients were evaluated for our primary outcome, PA (International PA<b> </b>Questionnaire) and secondary outcomes, mass, BMI, body fat %, HRQoL, insulin resistance,<b> </b>triglycerides (TG) and total (TC), high-density lipoprotein (HDL-C) and low-density lipoprotein<b> </b>(LDL-C) cholesterol were assessed at baseline and at 6-months. <b>Results: </b>On the basis of linear mixed-model analyses adjusted for baseline values<b> </b>performed on 40 patients in each group, total, leisure and vigorous PA significantly<b> </b>increased from baseline to post-intervention in the intervention compared to usual care<b> </b>(between-group differences, 578.5 MET-min・wk<sup>-1</sup>, p=.024, 382.2 MET-min・wk<sup>-1</sup>, p=.010, and<b> </b>264.1 MET-min・wk<sup>-1</sup>, p=.007, respectively). Both body mass and BMI decreased significantly<b> </b>in the intervention compared to usual care (between-group differences, -1.6 kg, p=.040, and<b> </b>-.6 kg/m<sup>2</sup>, p=.020, respectively). Of the HRQoL variables, FACT-Breast, Trial Outcome<b> </b>Index, functional wellbeing, and breast cancer subscale improved significantly in the PA<b> </b>group compared to the usual care group (between-group differences, 5.1, p<i>=</i>.024; 5.6,<b> </b>p=.001; 1.9 p=.025; and 2.8, p<i>=</i>.007, respectively). Finally, TC and LDL-C was significantly<b> </b>reduced in the PA group compared to the usual care group (between-group differences, -.38<b> </b>mmol・L<sup>-1</sup>, p<i>=</i>.001; and -.3 mmol・L<sup>-1</sup>, p<i>=</i>.023, respectively).<b>Conclusions: </b>We found that home-based PA resulted in significant albeit small to moderate<b> </b>improvements in self-reported PA, mass, BMI, breast cancer specific HRQoL, and TC and<b> </b>LDL-C compared with usual care. <br><br><br>
DOI: 10.6084/m9.figshare.3082990
title: Library Carpentry. Weeks One-Four. November 2015

description: <pre>This fileset contains lesson materials for Library Carpentry weeks one to four, held 9, 16, 23, and 30 November 2015 at City University London. Materials archived from https://github.com/LibraryCarpentry on 3 March 2016. Library Carpentry is generously funded by the [Software Sustainability Institute](http://software.ac.uk/). The Software Sustainability Institute cultivates world-class research with software. The Institute is based at the universities of Edinburgh, Manchester, Southampton and Oxford. The lesson are licensed under a Creative Commons Attribution-ShareAlike 4.0 International License. ***Exceptions: embeds to and from external sources, and direct quotations from speakers***</pre>
DOI: 10.6084/m9.figshare.3083047.v1
title: Characterization of a new species in the genus <i>Didymosphenia</i> and of <i>Cymbella janischii</i> (Bacillariophyta) from Connecticut, USA

description: Two non-native stalk-forming diatoms that were recently observed in the West Branch of the Farmington River, a tributary of the Connecticut River in Connecticut (USA), are characterized morphologically and barcode marker sequences were obtained for each of them. <i>Cymbella janischii</i>, the dominant stalk-forming species during the summer of 2012, previously had not been found in the northeastern USA. Samples of <i>C. janischii</i> were examined microscopically and used to obtain four sequences of the barcode marker, the V4 region of the 18S rDNA gene. Phylogenetic analysis indicated that the four independent sequences of <i>C. janischii</i> were distinct from, but most closely related to, published sequences of <i>C. janischii</i> from Idaho and <i>C. mexicana</i> from Texas, USA. A second non-native stalk-producing diatom, resembling <i>Didymosphenia geminata</i>, was found in November 2012 – June 2013 and first reported as <i>Didymosphenia</i> sp. Over this period, the observed cells had a compressed morphology and were consistently small compared with <i>D. geminata</i>. Sequences of the V4 region, obtained from three independent direct polymerase chain reactions (PCR) of single cells isolated from the Connecticut samples, indicated a close relationship to three published sequences of <i>D. geminata</i> from Italy, New Zealand and the USA, and to <i>D. siberica</i> and <i>D. dentata</i> from Russia. Frustules of the cells used in the PCR reactions were recovered and examined using scanning electron microscopy, providing a direct link between the observed morphology and sequence data. The morphology of the novel Connecticut <i>Didymosphenia</i> taxon was compared with that of other <i>Didymosphenia</i> taxa, being most similar to <i>D. pumila</i>, <i>D. laticollis</i>, <i>D. grunowii</i> and smaller cells of <i>D. geminata. Didymosphenia</i> sp. had a triundulate morphology with a consistent length of 40–60 µm. Given the unique morphological features of this diatom, it is proposed as a new species, <i>Didymosphenia hullii</i> Khan-Bureau, sp. nov.
DOI: 10.6084/m9.figshare.3082825.v1
title: Parper network datas

description: Data are generated using the algorithm proposed by Lancichinetti A, et al. ( Physical Review E. 2008;78(4):046110)
DOI: 10.6084/m9.figshare.3082990.v2
title: Library Carpentry. Weeks One-Four. November 2015

description: <pre>This fileset contains lesson materials for Library Carpentry weeks one to four, held 9, 16, 23, and 30 November 2015 at City University London. Materials archived from https://github.com/LibraryCarpentry on 3 March 2016. Library Carpentry is generously funded by the [Software Sustainability Institute](http://software.ac.uk/). The Software Sustainability Institute cultivates world-class research with software. The Institute is based at the universities of Edinburgh, Manchester, Southampton and Oxford. The lesson are licensed under a Creative Commons Attribution-ShareAlike 4.0 International License. ***Exceptions: embeds to and from external sources, and direct quotations from speakers***</pre>
DOI: 10.6084/m9.figshare.3082990.v1
title: Library Carpentry. Weeks One-Four. November 2015

description: <pre>This fileset contains lesson materials for Library Carpentry weeks one to four, held 9, 16, 23, and 30 November 2015 at City University London. Materials archived from https://github.com/LibraryCarpentry on 3 March 2016. Library Carpentry is generously funded by the [Software Sustainability Institute](http://software.ac.uk/). The Software Sustainability Institute cultivates world-class research with software. The Institute is based at the universities of Edinburgh, Manchester, Southampton and Oxford. The lesson are licensed under a Creative Commons Attribution-ShareAlike 4.0 International License. ***Exceptions: embeds to and from external sources, and direct quotations from speakers***</pre>
DOI: 10.6084/m9.figshare.3082192
title: Deep inspiration breath-hold volumetric modulated arc radiotherapy decreases dose to mediastinal structures in locally advanced lung cancer

description: Deep inspiration breath-hold volumetric modulated arc radiotherapy decreases dose to mediastinal structures in locally advanced lung cancer
DOI: 10.6084/m9.figshare.3082192.v1
title: Deep inspiration breath-hold volumetric modulated arc radiotherapy decreases dose to mediastinal structures in locally advanced lung cancer

description: Deep inspiration breath-hold volumetric modulated arc radiotherapy decreases dose to mediastinal structures in locally advanced lung cancer
DOI: 10.6084/m9.figshare.3082198
title: Fear of cancer recurrence in prostate cancer survivors

description: <b>Background</b> High fear of cancer recurrence (FCR) is an understudied topic in prostate cancer (PCa) survivors. This study aimed to detect the prevalence, consequences and characteristics associated with high FCR in PCa survivors. <b>Material and methods</b> This cross-sectional study included patients diagnosed with localized PCa and treated with curative radical prostatectomy between 1992 and 2012. We administered the Cancer Worry Scale (CWS) to assess FCR severity (primary outcome measure). Secondary outcomes included distress, quality of life (QOL), post-traumatic symptoms, and multidimensional aspects of FCR. χ<sup>2</sup>-tests, <i>t</i>-tests and Pearson’s correlations examined the relationship between FCR and medical/demographic characteristics. MANOVA analyses and χ2-tests identified differences between PCa survivors with high and low FCR. <b>Results</b> Two hundred eighty-three PCa survivors (median age of 70.0 years) completed the questionnaires a median time of 7.1 years after surgery. About a third (36%) of all PCa survivors experienced high FCR. High FCR was associated with lower QOL, more physical problems, higher distress and more post-traumatic stress symptoms. PCa survivors with high FCR reported disease-related triggers (especially medical examinations), felt helpless and experienced problems in social relationships. High FCR was associated with a younger age and having received adjuvant radiotherapy. <b>Conclusions</b> Results illustrate that FCR is a significant problem in PCa survivors. Younger men and those treated with adjuvant radiotherapy are especially at risk. Those with high FCR experience worse QOL and higher symptom burden. Health care providers should pay specific attention to this problem and provide appropriate psychosocial care when needed.
DOI: 10.6084/m9.figshare.3082198.v1
title: Fear of cancer recurrence in prostate cancer survivors

description: <b>Background</b> High fear of cancer recurrence (FCR) is an understudied topic in prostate cancer (PCa) survivors. This study aimed to detect the prevalence, consequences and characteristics associated with high FCR in PCa survivors. <b>Material and methods</b> This cross-sectional study included patients diagnosed with localized PCa and treated with curative radical prostatectomy between 1992 and 2012. We administered the Cancer Worry Scale (CWS) to assess FCR severity (primary outcome measure). Secondary outcomes included distress, quality of life (QOL), post-traumatic symptoms, and multidimensional aspects of FCR. χ<sup>2</sup>-tests, <i>t</i>-tests and Pearson’s correlations examined the relationship between FCR and medical/demographic characteristics. MANOVA analyses and χ2-tests identified differences between PCa survivors with high and low FCR. <b>Results</b> Two hundred eighty-three PCa survivors (median age of 70.0 years) completed the questionnaires a median time of 7.1 years after surgery. About a third (36%) of all PCa survivors experienced high FCR. High FCR was associated with lower QOL, more physical problems, higher distress and more post-traumatic stress symptoms. PCa survivors with high FCR reported disease-related triggers (especially medical examinations), felt helpless and experienced problems in social relationships. High FCR was associated with a younger age and having received adjuvant radiotherapy. <b>Conclusions</b> Results illustrate that FCR is a significant problem in PCa survivors. Younger men and those treated with adjuvant radiotherapy are especially at risk. Those with high FCR experience worse QOL and higher symptom burden. Health care providers should pay specific attention to this problem and provide appropriate psychosocial care when needed.
DOI: 10.6084/m9.figshare.3082183
title: Population scenarios for Central Germany

description: Population scenarios for Central Germany: The population scenarios for Central Germany are based on the 12th population prognosis of the federal bureau of statistics available on www.destatis.de. For the scenario building we used the variants V1W1 and V1W2 (see original data and leaflet p 37). Detailed information on the assumptions used for the different variants are presented in the official dataset and leaflet. See readme page in population scenario file for more details.<br>
DOI: 10.6084/m9.figshare.3082180
title: PNAS data on ecosystem functions tre communities and multifunctionality

description: Data on tree biodiversity (alpha and beta), abiotic conditions, heterogeneity, community composition and ecosystem multifunctionality in forest landscapes, associated with the PNAS manuscrpt entitled "Biotic homogenization can decrease landscape-scale forest multifunctionality"
DOI: 10.6084/m9.figshare.3082189
title: Testing the methodology for dosimetry audit of heterogeneity corrections and small MLC-shaped fields: Results of IAEA multi-center studies

description: The International Atomic Energy Agency (IAEA) has a long tradition of supporting development of methodologies for national networks providing quality audits in radiotherapy. A series of co-ordinated research projects (CRPs) has been conducted by the IAEA since 1995 assisting national external audit groups developing national audit programs. The CRP ‘Development of Quality Audits for Radiotherapy Dosimetry for Complex Treatment Techniques’ was conducted in 2009–2012 as an extension of previously developed audit programs. <i>Material and methods.</i> The CRP work described in this paper focused on developing and testing two steps of dosimetry audit: verification of heterogeneity corrections, and treatment planning system (TPS) modeling of small MLC fields, which are important for the initial stages of complex radiation treatments, such as IMRT. The project involved development of a new solid slab phantom with heterogeneities containing special measurement inserts for thermoluminescent dosimeters (TLD) and radiochromic films. The phantom and the audit methodology has been developed at the IAEA and tested in multi-center studies involving the CRP participants. <i>Results.</i> The results of multi-center testing of methodology for two steps of dosimetry audit show that the design of audit procedures is adequate and the methodology is feasible for meeting the audit objectives. A total of 97% TLD results in heterogeneity situations obtained in the study were within 3% and all results within 5% agreement with the TPS predicted doses. In contrast, only 64% small beam profiles were within 3 mm agreement between the TPS calculated and film measured doses. Film dosimetry results have highlighted some limitations in TPS modeling of small beam profiles in the direction of MLC leave movements. <i>Discussion.</i> Through multi-center testing, any challenges or difficulties in the proposed audit methodology were identified, and the methodology improved. Using the experience of these studies, the participants could incorporate the auditing procedures in their national programs.
DOI: 10.6084/m9.figshare.3082189.v1
title: Testing the methodology for dosimetry audit of heterogeneity corrections and small MLC-shaped fields: Results of IAEA multi-center studies

description: The International Atomic Energy Agency (IAEA) has a long tradition of supporting development of methodologies for national networks providing quality audits in radiotherapy. A series of co-ordinated research projects (CRPs) has been conducted by the IAEA since 1995 assisting national external audit groups developing national audit programs. The CRP ‘Development of Quality Audits for Radiotherapy Dosimetry for Complex Treatment Techniques’ was conducted in 2009–2012 as an extension of previously developed audit programs. <i>Material and methods.</i> The CRP work described in this paper focused on developing and testing two steps of dosimetry audit: verification of heterogeneity corrections, and treatment planning system (TPS) modeling of small MLC fields, which are important for the initial stages of complex radiation treatments, such as IMRT. The project involved development of a new solid slab phantom with heterogeneities containing special measurement inserts for thermoluminescent dosimeters (TLD) and radiochromic films. The phantom and the audit methodology has been developed at the IAEA and tested in multi-center studies involving the CRP participants. <i>Results.</i> The results of multi-center testing of methodology for two steps of dosimetry audit show that the design of audit procedures is adequate and the methodology is feasible for meeting the audit objectives. A total of 97% TLD results in heterogeneity situations obtained in the study were within 3% and all results within 5% agreement with the TPS predicted doses. In contrast, only 64% small beam profiles were within 3 mm agreement between the TPS calculated and film measured doses. Film dosimetry results have highlighted some limitations in TPS modeling of small beam profiles in the direction of MLC leave movements. <i>Discussion.</i> Through multi-center testing, any challenges or difficulties in the proposed audit methodology were identified, and the methodology improved. Using the experience of these studies, the participants could incorporate the auditing procedures in their national programs.
DOI: 10.6084/m9.figshare.3082168
title: Iddawela et al, Reliable gene expression profiling of formalin-fixed paraffin-embedded breast cancer tissue (FFPE) using cDNA-mediated Annealing, Extension, Selection, and Ligation Whole-Genome (DASL WG) assay.

description: Gene expression data from Iddawela et al, Reliable gene expression profiling of formalin-fixed paraffin-embedded breast cancer tissue (FFPE) using cDNA-mediated Annealing, Extension, Selection, and Ligation Whole-Genome (DASL WG) assay. (2016). BMC Medical Genomics
DOI: 10.6084/m9.figshare.3082159
title: Impact neutrality_part 2

description: This Excel file provides information about 568 journals' rejection rates and impact factors percentile. This represents about 5% of the 2014 Journal Citation Reports.The data sources are listed on the right hand side of the last column.Note: This data is not exhaustive nor is it necessarily representative of Open Access as a whole.