cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.30032856
title: Unmasking disparities in bladder cancer outcomes in the disaggregated Asian American population

description: Research on urothelial carcinoma of the bladder (UCUB) in non-Hispanic Asian American (NHAA) populations typically amalgamate all subgroups, masking significant intra-ethnic difference. This study aimed to examine variations in UCUB characteristics and outcomes within NHAA populations. Patients with UCUB were identified from the Surveillance, Epidemiology, and End Results database. The NHAA cohort disaggregated into Chinese, Filipino, South Asian, Japanese, Korean, Vietnamese, and other Asian subgroups. Kaplan-Meier and Cox proportional hazards models were used to estimate unadjusted and adjusted overall survival (OS) and cancer-specific survival (CSS). NHAA patients (<i>n</i> = 2,686) exhibited the longest median OS (88 months) compared to other cohorts (<i>p</i> &lt; 0.001). Among NHAA subgroups, five-year OS rates ranged from 50% in Filipino patients to 64% in other Asian groups. In adjusted analyses, Chinese (HR 0.84, 95% CI 0.74–0.94), Korean (HR 0.74, 95% CI 0.61–0.91), and other Asian (HR 0.68, 95% CI 0.56–0.82) patients exhibited significantly reduced mortality risk relative to Non-Hispanic White patients. Filipino Americans faced comparatively poorer survival, while Chinese and Korean Americans showed more favorable prognoses. These findings highlight the need for targeted, culturally tailored interventions and refined risk stratification to enhance equity in the management of UCUB.
DOI: 10.6084/m9.figshare.30032856.v1
title: Unmasking disparities in bladder cancer outcomes in the disaggregated Asian American population

description: Research on urothelial carcinoma of the bladder (UCUB) in non-Hispanic Asian American (NHAA) populations typically amalgamate all subgroups, masking significant intra-ethnic difference. This study aimed to examine variations in UCUB characteristics and outcomes within NHAA populations. Patients with UCUB were identified from the Surveillance, Epidemiology, and End Results database. The NHAA cohort disaggregated into Chinese, Filipino, South Asian, Japanese, Korean, Vietnamese, and other Asian subgroups. Kaplan-Meier and Cox proportional hazards models were used to estimate unadjusted and adjusted overall survival (OS) and cancer-specific survival (CSS). NHAA patients (<i>n</i> = 2,686) exhibited the longest median OS (88 months) compared to other cohorts (<i>p</i> &lt; 0.001). Among NHAA subgroups, five-year OS rates ranged from 50% in Filipino patients to 64% in other Asian groups. In adjusted analyses, Chinese (HR 0.84, 95% CI 0.74–0.94), Korean (HR 0.74, 95% CI 0.61–0.91), and other Asian (HR 0.68, 95% CI 0.56–0.82) patients exhibited significantly reduced mortality risk relative to Non-Hispanic White patients. Filipino Americans faced comparatively poorer survival, while Chinese and Korean Americans showed more favorable prognoses. These findings highlight the need for targeted, culturally tailored interventions and refined risk stratification to enhance equity in the management of UCUB.
DOI: 10.6084/m9.figshare.30490324
title: Upper and lower limb cryotherapy as a preventive strategy for taxane-induced peripheral neuropathy in breast cancer patients: a systematic review and meta-analysis

description: Peripheral neuropathy is a well-known complication in patients undergoing taxane chemotherapy. Several measures to prevent this condition have been tried, but none have yielded conclusive results. MEDLINE, Embase, Cochrane, and Web of Science databases were searched for randomized (RCTs) and self-controlled (SCTs) trials comparing cryotherapy with standard care in patients with breast cancer undergoing taxane-based chemotherapy and reporting any of the following outcomes: (1) chemotherapy-induced peripheral neuropathy (CIPN) or (2) adverse events. A total of 395 patients from 10 studies were included, all female. The age of participants ranged from 49.8 to 56.1 years. Incidence of any-grade CIPN was not significantly different between groups (RCTs RR 0.59; 95% CI 0.21–1.66; <i>p</i> = 0.320; SCTs RR 0.40; 95% CI 0.10–1.62; <i>p</i> = 0.198). No difference was observed in adverse events leading to discontinuation of cryotherapy (RCTs RR 0.72; 95% CI 0.17–3.05; <i>p</i> = 0.660; SCTs RR 1.09; 95% CI 0.51–2.34; <i>p</i> = 0.821). Cryotherapy was not statistically superior to the standard of care in reducing CIPN, without an increased risk of adverse events leading to discontinuation of cryotherapy. These findings underscore the need for further studies with more rigorous methodologies to definitively validate or rule out this finding. PROSPERO (CRD420251018990).
DOI: 10.6084/m9.figshare.31229843
title: Toxicity of elemental selenium and selenium substances after pulmonary exposure; and environmental and occupational air concentrations: a review

description: Selenium exposure via air can occur in the environment and workplace. To protect humans it is important to determine the concentrations at which different forms of selenium are toxic. We reviewed the literature on 1) selenium environmental and occupational air concentrations and 2) biokinetics and toxicity after pulmonary exposure. Environmental selenium ranged between 0.1 to 20 ng/m<sup>3</sup>, while occupational selenium was up to 2 mg/m<sup>3</sup>. Inhaled selenium distributes to blood and as demonstrated in animals to the internal organs. Excretion has been demonstrated to occur via urine, feces and breath. Toxicity data are scarce: two studies with occupational exposure to elemental selenium showed no effect at 0.11 and 0.32 mg Se/m<sup>3</sup>. In guinea pigs, inhalation of elemental selenium indicated a lowest-observed-adverse-effect concentration (LOAEC) of 33 mg Se/m<sup>3</sup> on affected lung and spleen (no controls available). Inhalation of hydrogen selenide in the same species resulted in a LOAEC of 1 mg Se/m<sup>3</sup> on lethality. Animal studies using intratracheal instillation resulted in lowest-observed-adverse-effect levels (LOAELs) set on lung function of 0.06 mg Se/kg bodyweight (bw) (selenite), and 0.6 mg Se/kg bw (selenium dioxide). For dimethyl selenide, a LOAEL on lethality was 0.1 mg Se/kg bw. In conclusion, environmental selenium ranges from 0.1 to 20 ng Se/m<sup>3</sup>, while occupational selenium levels can be magnitudes higher. Selenium distributes to blood and internal organs after pulmonary exposure. Animal inhalation studies indicate LOAECs of 1 and 33 mg Se/m<sup>3</sup>, while LOAELs of intratracheal instillation studies start at 0.06 mg Se/kg bw.
DOI: 10.6084/m9.figshare.31229843.v1
title: Toxicity of elemental selenium and selenium substances after pulmonary exposure; and environmental and occupational air concentrations: a review

description: Selenium exposure via air can occur in the environment and workplace. To protect humans it is important to determine the concentrations at which different forms of selenium are toxic. We reviewed the literature on 1) selenium environmental and occupational air concentrations and 2) biokinetics and toxicity after pulmonary exposure. Environmental selenium ranged between 0.1 to 20 ng/m<sup>3</sup>, while occupational selenium was up to 2 mg/m<sup>3</sup>. Inhaled selenium distributes to blood and as demonstrated in animals to the internal organs. Excretion has been demonstrated to occur via urine, feces and breath. Toxicity data are scarce: two studies with occupational exposure to elemental selenium showed no effect at 0.11 and 0.32 mg Se/m<sup>3</sup>. In guinea pigs, inhalation of elemental selenium indicated a lowest-observed-adverse-effect concentration (LOAEC) of 33 mg Se/m<sup>3</sup> on affected lung and spleen (no controls available). Inhalation of hydrogen selenide in the same species resulted in a LOAEC of 1 mg Se/m<sup>3</sup> on lethality. Animal studies using intratracheal instillation resulted in lowest-observed-adverse-effect levels (LOAELs) set on lung function of 0.06 mg Se/kg bodyweight (bw) (selenite), and 0.6 mg Se/kg bw (selenium dioxide). For dimethyl selenide, a LOAEL on lethality was 0.1 mg Se/kg bw. In conclusion, environmental selenium ranges from 0.1 to 20 ng Se/m<sup>3</sup>, while occupational selenium levels can be magnitudes higher. Selenium distributes to blood and internal organs after pulmonary exposure. Animal inhalation studies indicate LOAECs of 1 and 33 mg Se/m<sup>3</sup>, while LOAELs of intratracheal instillation studies start at 0.06 mg Se/kg bw.
DOI: 10.25420/britishmuseum.31185595
title: Removing of the loom elements

description: Audio recording of the process of removing the elements of a weaving loom, then when the carpet is removed from the loom. Explanation of how the elements of the loom should be preserved, so that they do not deteriorate. The bearers of weaving knowledge from the village of Stoianovca participate in the process.
DOI: 10.25420/britishmuseum.31185595.v1
title: Removing of the loom elements

description: Audio recording of the process of removing the elements of a weaving loom, then when the carpet is removed from the loom. Explanation of how the elements of the loom should be preserved, so that they do not deteriorate. The bearers of weaving knowledge from the village of Stoianovca participate in the process.
DOI: 10.6084/m9.figshare.30490324.v1
title: Upper and Lower limb cryotherapy as a preventive strategy for taxane-induced peripheral neuropathy in breast cancer patients: a systematic review and meta-analysis

description: Peripheral neuropathy is a well-known complication in patients undergoing taxane chemotherapy. Several measures to prevent this condition have been tried, but none have yielded conclusive results. MEDLINE, Embase, Cochrane, and Web of Science databases were searched for randomized (RCTs) and self-controlled (SCTs) trials comparing cryotherapy with standard care in patients with breast cancer undergoing taxane-based chemotherapy and reporting any of the following outcomes: (1) chemotherapy-induced peripheral neuropathy (CIPN) or (2) adverse events. A total of 395 patients from ten studies were included, all female. The age of participants ranged from 49.8 to 56.1 years. Incidence of any-grade CIPN was not significantly different between groups (RCTs RR 0.59; 95% CI 0.21-1.66; <i>p</i> = 0.320; SCTs RR 0.40; 95% CI 0.10-1.62; <i>p</i> = 0.198). No difference was observed in adverse events leading to discontinuation of cryotherapy (RCTs RR 0.72; 95% CI 0.17-3.05; <i>p</i> = 0.660; SCTs RR 1.09; 95% CI 0.51-2.34; <i>p</i> = 0.821). Cryotherapy was not statistically superior to the standard of care in reducing CIPN, without an increased risk of adverse events leading to discontinuation of cryotherapy. These findings underscore the need for further studies with more rigorous methodologies to definitively validate or rule out this finding. PROSPERO (CRD420251018990).
DOI: 10.6084/m9.figshare.30490324.v2
title: Upper and lower limb cryotherapy as a preventive strategy for taxane-induced peripheral neuropathy in breast cancer patients: a systematic review and meta-analysis

description: Peripheral neuropathy is a well-known complication in patients undergoing taxane chemotherapy. Several measures to prevent this condition have been tried, but none have yielded conclusive results. MEDLINE, Embase, Cochrane, and Web of Science databases were searched for randomized (RCTs) and self-controlled (SCTs) trials comparing cryotherapy with standard care in patients with breast cancer undergoing taxane-based chemotherapy and reporting any of the following outcomes: (1) chemotherapy-induced peripheral neuropathy (CIPN) or (2) adverse events. A total of 395 patients from 10 studies were included, all female. The age of participants ranged from 49.8 to 56.1 years. Incidence of any-grade CIPN was not significantly different between groups (RCTs RR 0.59; 95% CI 0.21–1.66; <i>p</i> = 0.320; SCTs RR 0.40; 95% CI 0.10–1.62; <i>p</i> = 0.198). No difference was observed in adverse events leading to discontinuation of cryotherapy (RCTs RR 0.72; 95% CI 0.17–3.05; <i>p</i> = 0.660; SCTs RR 1.09; 95% CI 0.51–2.34; <i>p</i> = 0.821). Cryotherapy was not statistically superior to the standard of care in reducing CIPN, without an increased risk of adverse events leading to discontinuation of cryotherapy. These findings underscore the need for further studies with more rigorous methodologies to definitively validate or rule out this finding. PROSPERO (CRD420251018990).
DOI: 10.6084/m9.figshare.30885295
title: Impact of patent-granting differences between Japan and the United States on patent protection for medical methods: insights from genome editing patents

description: Securing patents in multiple countries has become essential for the development of global medical products. However, differences in national patent systems result in varying patentability standards. Although global claim construction strategies have been applied in practice, these approaches have not yet been systematically organized. This study examines how the patent scope for patent families of international applications related to genome editing technologies filed in 2013, differs between Japan, where medical method patents are prohibited, and the United States, where such patents are permitted. For CRISPR-Cas system patents, claim structures varied significantly, even among the corresponding family patents. To navigate these differences, the following strategies were proposed for filing patents in countries that prohibit medical method patents such as Japan:
Convert medical method claims in the U.S. into composition claims that include product inventions, as this process ensures that such claims allow for the enforcement of rights against the suppliers of infringing products.Clearly define the scope of the claimed use-inventions when specifying the characteristics of the product based on its effects.Explicitly describe cells produced by a specific manufacturing method within the claimed rights. Convert medical method claims in the U.S. into composition claims that include product inventions, as this process ensures that such claims allow for the enforcement of rights against the suppliers of infringing products. Clearly define the scope of the claimed use-inventions when specifying the characteristics of the product based on its effects. Explicitly describe cells produced by a specific manufacturing method within the claimed rights.
DOI: 10.6084/m9.figshare.30885295.v1
title: Impact of patent-granting differences between Japan and the United States on patent protection for medical methods: insights from genome editing patents

description: Securing patents in multiple countries has become essential for the development of global medical products. However, differences in national patent systems result in varying patentability standards. Although global claim construction strategies have been applied in practice, these approaches have not yet been systematically organized. This study examines how the patent scope for patent families of international applications related to genome editing technologies filed in 2013, differs between Japan, where medical method patents are prohibited, and the United States, where such patents are permitted. For CRISPR-Cas system patents, claim structures varied significantly, even among the corresponding family patents. To navigate these differences, the following strategies were proposed for filing patents in countries that prohibit medical method patents such as Japan:
Convert medical method claims in the U.S. into composition claims that include product inventions, as this process ensures that such claims allow for the enforcement of rights against the suppliers of infringing products.Clearly define the scope of the claimed use-inventions when specifying the characteristics of the product based on its effects.Explicitly describe cells produced by a specific manufacturing method within the claimed rights. Convert medical method claims in the U.S. into composition claims that include product inventions, as this process ensures that such claims allow for the enforcement of rights against the suppliers of infringing products. Clearly define the scope of the claimed use-inventions when specifying the characteristics of the product based on its effects. Explicitly describe cells produced by a specific manufacturing method within the claimed rights.
DOI: 10.6084/m9.figshare.31229818
title: <b>Supplementary Tables</b> - Chagas cardiomyopathy epigenomics

description: This dataset contains the supplementary tables associated with the manuscript entitled:<b> Integrated methylome and transcriptome analysis in chronic Chagas cardiomyopathy uncovers alterations in heart development</b>
DOI: 10.6084/m9.figshare.31229818.v1
title: <b>Supplementary Tables</b> - Chagas cardiomyopathy epigenomics

description: This dataset contains the supplementary tables associated with the manuscript entitled:<b> Integrated methylome and transcriptome analysis in chronic Chagas cardiomyopathy uncovers alterations in heart development</b>
DOI: 10.6084/m9.figshare.28710698
title: List of newspaper items for scoping review

description: This is the full list of search results (<i>n</i> = 81 355) for our scoping review on Scandinavian tundra tongue cases. The csv file has seven columns:id - a unique record id derived from the urltitle - the title of the record, typically newspaper name and datecountry - whether the source is Norway (no), Sweden (se) or Denmark (dk)search_string - the search string used to identify the itemproximity - the proximity distance used together with the search stringstatus - whether the record was included, excluded or unavailablelink - URL to access the itemThe dataset is used in the following publication: Demography and outcomes of frozen tongue: a scoping review of Scandinavian tundra tongue cases
DOI: 10.6084/m9.figshare.28710698.v1
title: List of newspaper items for scoping review

description: This is the full list of search results (<i>n</i> = 81 355) for our scoping review on Scandinavian tundra tongue cases. The csv file has seven columns:id - a unique record id derived from the urltitle - the title of the record, typically newspaper name and datecountry - whether the source is Norway (no), Sweden (se) or Denmark (dk)search_string - the search string used to identify the itemproximity - the proximity distance used together with the search stringstatus - whether the record was included, excluded or unavailablelink - URL to access the itemThe dataset is used in the following publication: Demography and outcomes of frozen tongue: a scoping review of Scandinavian tundra tongue cases
DOI: 10.25420/britishmuseum.31185781
title: Prezentation for Workshop on dyeing wool yarn with natural dyes

description: Presentation prepared by Ciobanu Irina, restorer from the National Museum of Ethnography and Natural History from Chisinau. The content of the presentation introduced the participants to the secrets of dyeing different types of fibers with natural dyes.
DOI: 10.25420/britishmuseum.31185781.v1
title: Prezentation for Workshop on dyeing wool yarn with natural dyes

description: Presentation prepared by Ciobanu Irina, restorer from the National Museum of Ethnography and Natural History from Chisinau. The content of the presentation introduced the participants to the secrets of dyeing different types of fibers with natural dyes.
DOI: 10.25420/britishmuseum.31185784
title: List of participants at the Workshop on dyeing wool yarn with natural dyes

description: The list contains the names and surnames of the participants in the workshop on dyeing fibers with natural dyes from 20.10.2023.
DOI: 10.25420/britishmuseum.31185784.v1
title: List of participants at the Workshop on dyeing wool yarn with natural dyes

description: The list contains the names and surnames of the participants in the workshop on dyeing fibers with natural dyes from 20.10.2023.
DOI: 10.25420/britishmuseum.31185850
title: List of participants at the Carpet restoration workshop

description: The list contains the names and surnames of the participants in the workshop for the restoration of old carpets woven from various fibers from 21.10.2023.
DOI: 10.25420/britishmuseum.31185850.v1
title: List of participants at the Carpet restoration workshop

description: The list contains the names and surnames of the participants in the workshop for the restoration of old carpets woven from various fibers from 21.10.2023.
DOI: 10.6084/m9.figshare.31198033
title: Dynamic bow snap-through in electrostatically actuated microbeams under prestress tuning

description: A curved bistable microbeam, subjected to electrostatic loading from an electrode facing its concave side, may exhibit bow snap-through ($BST$) at nearly half the voltage ($\approx \! 54\%$) when compared to actuation from the convex side. Previously, it was shown that introducing prestress can enable $BST$ where it is otherwise unattainable. The current work extends the $BST$ condition to include dynamic actuation, thus establishing dynamic bow snap-through ($DBST$) as a viable and sustainable form of actuation, since it can reduce actuation by $\approx \! 10 \! - \! 16\%$. To enable analytical derivation while retaining generality across various loading scenarios, the analysis employs an undamped single-degree-of-freedom reduced-order model obtained via Galerkin's decomposition. The resulting formulation yields a necessary condition for $DBST$, expressed in terms of beam geometry, prestress, and initial conditions, forming a unified condition. Subsequent analysis shows that suddenly applied actuations, combined with prestress, can enable $BST$ over a wider range of parameters, whereas excessive kinetic energy and/or prestress can suppress $DBST$. The proposed condition provides practical design guidance for energy-efficient, low-voltage and non-volatile bistable devices.
DOI: 10.6084/m9.figshare.31198033.v1
title: Dynamic bow snap-through in electrostatically actuated microbeams under prestress tuning

description: A curved bistable microbeam, subjected to electrostatic loading from an electrode facing its concave side, may exhibit bow snap-through ($BST$) at nearly half the voltage ($\approx \! 54\%$) when compared to actuation from the convex side. Previously, it was shown that introducing prestress can enable $BST$ where it is otherwise unattainable. The current work extends the $BST$ condition to include dynamic actuation, thus establishing dynamic bow snap-through ($DBST$) as a viable and sustainable form of actuation, since it can reduce actuation by $\approx \! 10 \! - \! 16\%$. To enable analytical derivation while retaining generality across various loading scenarios, the analysis employs an undamped single-degree-of-freedom reduced-order model obtained via Galerkin's decomposition. The resulting formulation yields a necessary condition for $DBST$, expressed in terms of beam geometry, prestress, and initial conditions, forming a unified condition. Subsequent analysis shows that suddenly applied actuations, combined with prestress, can enable $BST$ over a wider range of parameters, whereas excessive kinetic energy and/or prestress can suppress $DBST$. The proposed condition provides practical design guidance for energy-efficient, low-voltage and non-volatile bistable devices.
DOI: 10.25420/britishmuseum.31186042
title: Essay contest about traditional Bulgarian carpets among students of the Stoianovca gymnasium

description: the work of the student Cholkovan Darya, 17 years old, age category up to 18 years old. She participated in the essay competition with the general title "My Grandmother's Carpet", held between 17.11.2023 - 15.12.2023. Darya took first place in her age category.
DOI: 10.25420/britishmuseum.31186042.v1
title: Essay contest about traditional Bulgarian carpets among students of the Stoianovca gymnasium

description: the work of the student Cholkovan Darya, 17 years old, age category up to 18 years old. She participated in the essay competition with the general title "My Grandmother's Carpet", held between 17.11.2023 - 15.12.2023. Darya took first place in her age category.