cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.19940159
title: Temporal and spatial differences in the intensity of human activity based on land cover change in North-central China during the Holocene

description: Beginning in the middle-late Holocene, anthropogenic land cover change has a profound impact on both regional and continental environments. Here we used two representative pollen records in North China and a novel methodological to quantitatively reconstruct the Holocene land cover changes. The results indicate diverse vegetation succession patterns in different regions and geomorphologic contexts. Changes in the intensity of human activities may one major reason of contribute to regional disparities in vegetation succession. In larger basin/plain areas, the favorable climatic conditions during the mid-Holocene promoted human activities; while later, population pressure, the increased demand for resources, and political factors may have triggered the diffusion of human populations from basins to the mountains or undeveloped areas with resulting effects on their vegetation succession. The anthropogenic impacts dominated the natural environment in Mountainous areas at least for the last 1,300 years.
DOI: 10.6084/m9.figshare.19940159.v2
title: Temporal and spatial differences in the intensity of human activity based on land cover change in North-central China during the Holocene

description: Beginning in the middle-late Holocene, anthropogenic land cover change has a profound impact on both regional and continental environments. Here we used two representative pollen records in North China and a novel methodological to quantitatively reconstruct the Holocene land cover changes. The results indicate diverse vegetation succession patterns in different regions and geomorphologic contexts. Changes in the intensity of human activities may one major reason of contribute to regional disparities in vegetation succession. In larger basin/plain areas, the favorable climatic conditions during the mid-Holocene promoted human activities; while later, population pressure, the increased demand for resources, and political factors may have triggered the diffusion of human populations from basins to the mountains or undeveloped areas with resulting effects on their vegetation succession. The anthropogenic impacts dominated the natural environment in Mountainous areas at least for the last 1,300 years.
DOI: 10.6084/m9.figshare.19940273.v1
title: SI.docx

description: Sequence similarity network and protein structure prediction provide evolutionary insights into the microbial ferrous iron oxidation pathways
DOI: 10.6084/m9.figshare.19921127
title: Additional file 1 of Effects of characteristic parameters on surface seismic aggravation in 2D sedimentary valley

description: Compared the Fourier amplitude spectra of the observed and simulated time series (Figure 4) at these stations from the 13 May 1995 earthquake, similar spectral values were amplified within the effective frequency band of the simulation while rapidly decreasing for more than 7hz. The 5% damped normalized acceleration response spectra of the selected strong-motion recordings. The design spectrum for site classes A (Type 1) recommended in the EC8 was used to match the unscaled accelerograms.
DOI: 10.6084/m9.figshare.19921127.v2
title: Additional file 1 of Effects of characteristic parameters on surface seismic aggravation in 2D sedimentary valley

description: Compared the Fourier amplitude spectra of the observed and simulated time series (Figure 4) at these stations from the 13 May 1995 earthquake, similar spectral values were amplified within the effective frequency band of the simulation while rapidly decreasing for more than 7hz. The 5% damped normalized acceleration response spectra of the selected strong-motion recordings. The design spectrum for site classes A (Type 1) recommended in the EC8 was used to match the unscaled accelerograms.
DOI: 10.6084/m9.figshare.19921127.v1
title: Additional file 1 of Effects of characteristic parameters on surface seismic aggravation in 2D sedimentary valley

description: Compared the Fourier amplitude spectra of the observed and simulated time series (Figure 4) at these stations from the 13 May 1995 earthquake, similar spectral values were amplified within the effective frequency band of the simulation while rapidly decreasing for more than 7hz. The 5% damped normalized acceleration response spectra of the selected strong-motion recordings. The design spectrum for site classes A (Type 1) recommended in the EC8 was used to match the unscaled accelerograms.
DOI: 10.6084/m9.figshare.19940168
title: Dataset for Government direction on the vocational school’s performance evaluation: A comparative analysis between Indonesia and Malaysia

description: This dataset consists of respondents' answers to a questionnaire related to vocational school performance evaluation in Indonesia and researchers' conclusions regarding the answers.
DOI: 10.6084/m9.figshare.19940168.v1
title: Dataset for Government direction on the vocational school’s performance evaluation: A comparative analysis between Indonesia and Malaysia

description: This dataset consists of respondents' answers to a questionnaire related to vocational school performance evaluation in Indonesia and researchers' conclusions regarding the answers.
DOI: 10.6084/m9.figshare.11452968
title: Pseudomonas aeruginosa in the ICU: prevalence, resistance profile, and antimicrobial consumption

description: Abstract INTRODUCTION: Pseudomonas aeruginosa is one of the main pathogens causing infection in intensive care units (ICUs) and usually presents antimicrobial resistance. METHODS: Data were obtained from ICUs between 2010 and 2013. RESULTS: P. aeruginosa had a prevalence of 14.5% of which 48.7% were multidrug resistant. We observed increasing resistance to carbapenems and polymyxin B and growing consumption of aminoglycosides, meropenem, ceftazidime, and polymyxin B. The regression impact between resistance and consumption was significant with respect to amikacin, imipenem, meropenem, and polymyxin B. CONCLUSIONS: Monitoring antimicrobial consumption and resistant microorganisms should be reinforced to combat antimicrobial- and multi-drug resistance.
DOI: 10.6084/m9.figshare.11452968.v1
title: Pseudomonas aeruginosa in the ICU: prevalence, resistance profile, and antimicrobial consumption

description: Abstract INTRODUCTION: Pseudomonas aeruginosa is one of the main pathogens causing infection in intensive care units (ICUs) and usually presents antimicrobial resistance. METHODS: Data were obtained from ICUs between 2010 and 2013. RESULTS: P. aeruginosa had a prevalence of 14.5% of which 48.7% were multidrug resistant. We observed increasing resistance to carbapenems and polymyxin B and growing consumption of aminoglycosides, meropenem, ceftazidime, and polymyxin B. The regression impact between resistance and consumption was significant with respect to amikacin, imipenem, meropenem, and polymyxin B. CONCLUSIONS: Monitoring antimicrobial consumption and resistant microorganisms should be reinforced to combat antimicrobial- and multi-drug resistance.
DOI: 10.6084/m9.figshare.11452980
title: Investigation of carbapenemases and aminoglycoside modifying enzymes of Acinetobacter baumannii isolates recovered from patients admitted to intensive care units in a tertiary-care hospital in Brazil

description: Abstract INTRODUCTION: Acinetobacter baumannii are opportunistic bacteria, highly capable of acquiring antimicrobial resistance through the production of carbapenemases and aminoglycoside modifying enzymes (AMEs). METHODS: Carbapenemase and AME genes were investigated in A. baumannii recovered from inpatients of a Brazilian hospital. RESULTS: The key genes found were bla OXA-51-like, the association ISAba1- bla OXA-23-like, and the AME genes aph(3´)-VI, aac(6´)-Ib, aac(3)-Ia, and aph(3´)-Ia. Different clusters spread through the institution wards. CONCLUSIONS: The dissemination of bla OXA-23-like and AME-carrying A. baumannii through the hospital highlights the need for improved preventive measures to reduce the spread of infection.
DOI: 10.6084/m9.figshare.19940327
title: Temporal and spatial differences in the intensity of human activity based on land cover change in North-central China during the Holocene

description: Beginning in the middle-late Holocene, anthropogenic land cover change has a profound impact on both regional and continental environments. Here we used two representative pollen records in North China and a novel methodological to quantitatively reconstruct the Holocene land cover changes. The results indicate diverse vegetation succession patterns in different regions and geomorphologic contexts. Changes in the intensity of human activities may one major reason of contribute to regional disparities in vegetation succession. In larger basin/plain areas, the favorable climatic conditions during the mid-Holocene promoted human activities; while later, population pressure, the increased demand for resources, and political factors may have triggered the diffusion of human populations from basins to the mountains or undeveloped areas with resulting effects on their vegetation succession. The anthropogenic impacts dominated the natural environment in Mountainous areas at least for the last 1,300 years.
DOI: 10.6084/m9.figshare.11452980.v1
title: Investigation of carbapenemases and aminoglycoside modifying enzymes of Acinetobacter baumannii isolates recovered from patients admitted to intensive care units in a tertiary-care hospital in Brazil

description: Abstract INTRODUCTION: Acinetobacter baumannii are opportunistic bacteria, highly capable of acquiring antimicrobial resistance through the production of carbapenemases and aminoglycoside modifying enzymes (AMEs). METHODS: Carbapenemase and AME genes were investigated in A. baumannii recovered from inpatients of a Brazilian hospital. RESULTS: The key genes found were bla OXA-51-like, the association ISAba1- bla OXA-23-like, and the AME genes aph(3´)-VI, aac(6´)-Ib, aac(3)-Ia, and aph(3´)-Ia. Different clusters spread through the institution wards. CONCLUSIONS: The dissemination of bla OXA-23-like and AME-carrying A. baumannii through the hospital highlights the need for improved preventive measures to reduce the spread of infection.
DOI: 10.6084/m9.figshare.11452983
title: Association of adverse drug reaction to anti-tuberculosis medication with quality of life in patients in a tertiary referral hospital

description: Abstract INTRODUCTION: Adverse drug reactions can develop when using anti-tuberculosis medication, and the effects of the drugs can also significantly hinder the treatment of patients. METHODS: A cross-sectional survey was conducted in 73 patients using two standardized questionnaires and the World Health Organization Quality of Life-Bref. RESULTS: All patients reported the presence of adverse drug reactions, 71.6% of which are minor and 28.3% both major and minor. The global quality of life analysis showed that patients with tuberculosis have a good average (67.3%). CONCLUSIONS: There is an association between quality of life and adverse drug reaction, educational level, and vulnerability.
DOI: 10.6084/m9.figshare.11452986
title: Human immunodeficiency virus/acquired immunodeficiency syndrome epidemic in adolescents from a Brazilian metropolis (1978-2017)

description: Abstract INTRODUCTION: Prevalence of human immunodeficiency virus among adolescents is increasing. This study aimed to analyze this current situation in Rio de Janeiro City. METHODS: This was a retrospective longitudinal study using secondary data from the National System of Notifiable Diseases database of cases in adolescents aged 13-19 years. RESULTS: There were 885 acquired immunodeficiency syndrome cases from 1978 to 2017 and 445 human immunodeficiency virus new cases from 2014 to 2017. Over time, sexually transmitted human immunodeficiency virus/acquired immunodeficiency syndrome cases increase. CONCLUSIONS: Human immunodeficiency virus/acquired immunodeficiency syndrome epidemic in adolescents requires novel prevention policies.
DOI: 10.6084/m9.figshare.11452986.v1
title: Human immunodeficiency virus/acquired immunodeficiency syndrome epidemic in adolescents from a Brazilian metropolis (1978-2017)

description: Abstract INTRODUCTION: Prevalence of human immunodeficiency virus among adolescents is increasing. This study aimed to analyze this current situation in Rio de Janeiro City. METHODS: This was a retrospective longitudinal study using secondary data from the National System of Notifiable Diseases database of cases in adolescents aged 13-19 years. RESULTS: There were 885 acquired immunodeficiency syndrome cases from 1978 to 2017 and 445 human immunodeficiency virus new cases from 2014 to 2017. Over time, sexually transmitted human immunodeficiency virus/acquired immunodeficiency syndrome cases increase. CONCLUSIONS: Human immunodeficiency virus/acquired immunodeficiency syndrome epidemic in adolescents requires novel prevention policies.
DOI: 10.6084/m9.figshare.19940327.v2
title: Temporal and spatial differences in the intensity of human activity based on land cover change in North-central China during the Holocene

description: Beginning in the middle-late Holocene, anthropogenic land cover change has a profound impact on both regional and continental environments. Here we used two representative pollen records in North China and a novel methodological to quantitatively reconstruct the Holocene land cover changes. The results indicate diverse vegetation succession patterns in different regions and geomorphologic contexts. Changes in the intensity of human activities may one major reason of contribute to regional disparities in vegetation succession. In larger basin/plain areas, the favorable climatic conditions during the mid-Holocene promoted human activities; while later, population pressure, the increased demand for resources, and political factors may have triggered the diffusion of human populations from basins to the mountains or undeveloped areas with resulting effects on their vegetation succession. The anthropogenic impacts dominated the natural environment in Mountainous areas at least for the last 1,300 years.
DOI: 10.6084/m9.figshare.11452983.v1
title: Association of adverse drug reaction to anti-tuberculosis medication with quality of life in patients in a tertiary referral hospital

description: Abstract INTRODUCTION: Adverse drug reactions can develop when using anti-tuberculosis medication, and the effects of the drugs can also significantly hinder the treatment of patients. METHODS: A cross-sectional survey was conducted in 73 patients using two standardized questionnaires and the World Health Organization Quality of Life-Bref. RESULTS: All patients reported the presence of adverse drug reactions, 71.6% of which are minor and 28.3% both major and minor. The global quality of life analysis showed that patients with tuberculosis have a good average (67.3%). CONCLUSIONS: There is an association between quality of life and adverse drug reaction, educational level, and vulnerability.
DOI: 10.6084/m9.figshare.11757012.v1
title: Hepatitis B: Prevalence and occult infection in HIV-infected patients

description: Abstract INTRODUCTION: HBV and HIV have identical transmission routes. The aim of this study was to determine the prevalence of HBV in HIV patients and to detect the presence of occult HBV infection. METHODS: All samples were tested for serology markers and using qPCR. RESULTS: This study included 232 individuals, out of which 36.6% presented with HBV markers and 11.8% presented with HBsAg or HBV-DNA, including 3 patients that showed OBI. CONCLUSIONS: We observed a high prevalence of HBV among HIV patients. In addition, the results suggest that OBI can occur in patients with serological profiles that are indicative of past infection. Therefore, the application of molecular tests may enable the identification of infections that are not evident solely based on serology.
DOI: 10.6084/m9.figshare.11452644
title: Prevalence of coinfections in women living with human immunodeficiency virus in Northeast Brazil

description: Abstract INTRODUCTION: Despite the success of antiretrovirals, human immunodeficiency virus (HIV) coinfections continue to cause mortality. We investigated the prevalence of coinfections in women with HIV/acquired immunodeficiency syndrome in Sergipe, Brazil. METHODS: We conducted a cross-sectional study. The coinfections investigated were syphilis, hepatitis B and C, toxoplasmosis, rubella, tuberculosis, and cytomegalovirus. RESULTS: Among the 435 women, 85 (19.5%) had coinfections. The most prevalent was HIV/syphilis, followed by tuberculosis, toxoplasmosis, hepatitis C, hepatitis B, and rubella. Additionally, 300 (96.2%) were seropositive for cytomegalovirus immunoglobulin G. CONCLUSIONS: Despite significant progress in the treatment for people with HIV, coinfections continued to affect this population.
DOI: 10.6084/m9.figshare.11452644.v1
title: Prevalence of coinfections in women living with human immunodeficiency virus in Northeast Brazil

description: Abstract INTRODUCTION: Despite the success of antiretrovirals, human immunodeficiency virus (HIV) coinfections continue to cause mortality. We investigated the prevalence of coinfections in women with HIV/acquired immunodeficiency syndrome in Sergipe, Brazil. METHODS: We conducted a cross-sectional study. The coinfections investigated were syphilis, hepatitis B and C, toxoplasmosis, rubella, tuberculosis, and cytomegalovirus. RESULTS: Among the 435 women, 85 (19.5%) had coinfections. The most prevalent was HIV/syphilis, followed by tuberculosis, toxoplasmosis, hepatitis C, hepatitis B, and rubella. Additionally, 300 (96.2%) were seropositive for cytomegalovirus immunoglobulin G. CONCLUSIONS: Despite significant progress in the treatment for people with HIV, coinfections continued to affect this population.
DOI: 10.6084/m9.figshare.19940327.v1
title: veg_recon

description: Beginning in the middle-late Holocene, anthropogenic land cover change has a profound impact on both regional and continental environments. Here we used two representative pollen records in North China and a novel methodological to quantitatively reconstruct the Holocene land cover changes. The results indicate diverse vegetation succession patterns in different regions and geomorphologic contexts. Changes in the intensity of human activities may one major reason of contribute to regional disparities in vegetation succession. In larger basin/plain areas, the favorable climatic conditions during the mid-Holocene promoted human activities; while later, population pressure, the increased demand for resources, and political factors may have triggered the diffusion of human populations from basins to the mountains or undeveloped areas with resulting effects on their vegetation succession. The anthropogenic impacts dominated the natural environment in Mountainous areas at least for the last 1,300 years.
DOI: 10.6084/m9.figshare.11756862
title: Human platelet antigen-3 polymorphism as a risk factor for rheumatological manifestations in hepatitis C

description: Abstract INTRODUCTION: Hepatitis C virus (HCV) infection is involved in the pathogenesis of autoimmune and rheumatic disorders. Although the human platelet antigens (HPA) polymorphism are associated with HCV persistence, they have not been investigated in rheumatological manifestations (RM). This study focused on verifying associations between allele and genotype HPA and RM in patients with chronic hepatitis C. METHODS: Patients (159) with chronic hepatitis C of both genders were analyzed. RESULTS: Women showed association between HPA-3 polymorphisms and RM. CONCLUSIONS: An unprecedented strong association between rheumatological manifestations and HPA-3 polymorphism, possibly predisposing women to complications during the disease course, was observed.
DOI: 10.6084/m9.figshare.11756922.v1
title: Characterization of adverse reactions to benznidazole in patients with Chagas disease in the Federal District, Brazil

description: Abstract INTRODUCTION: Benznidazole is used for treating Chagas disease (CD). This cross-sectional study aimed to characterize the adverse drug reactions (ADRs) of benznidazole at a public hospital in Brazil’s Federal District. METHODS: Medical records were analyzed and ADRs were categorized by type, intensity, seriousness, and causality. RESULTS: Of the 62 patients who started benznidazole treatment for CD, 41 (66%) presented with 105 ADRs; 23 (37%) discontinued the treatment. Most reactions were classified as probable (81%), severe (63%), serious (67%), and dose-dependent (56%). CONCLUSIONS: The high incidence of ADRs because of treatment withdrawal revealed the need for safer alternatives for CD treatment.
DOI: 10.6084/m9.figshare.11757012
title: Hepatitis B: Prevalence and occult infection in HIV-infected patients

description: Abstract INTRODUCTION: HBV and HIV have identical transmission routes. The aim of this study was to determine the prevalence of HBV in HIV patients and to detect the presence of occult HBV infection. METHODS: All samples were tested for serology markers and using qPCR. RESULTS: This study included 232 individuals, out of which 36.6% presented with HBV markers and 11.8% presented with HBsAg or HBV-DNA, including 3 patients that showed OBI. CONCLUSIONS: We observed a high prevalence of HBV among HIV patients. In addition, the results suggest that OBI can occur in patients with serological profiles that are indicative of past infection. Therefore, the application of molecular tests may enable the identification of infections that are not evident solely based on serology.
DOI: 10.6084/m9.figshare.11756922
title: Characterization of adverse reactions to benznidazole in patients with Chagas disease in the Federal District, Brazil

description: Abstract INTRODUCTION: Benznidazole is used for treating Chagas disease (CD). This cross-sectional study aimed to characterize the adverse drug reactions (ADRs) of benznidazole at a public hospital in Brazil’s Federal District. METHODS: Medical records were analyzed and ADRs were categorized by type, intensity, seriousness, and causality. RESULTS: Of the 62 patients who started benznidazole treatment for CD, 41 (66%) presented with 105 ADRs; 23 (37%) discontinued the treatment. Most reactions were classified as probable (81%), severe (63%), serious (67%), and dose-dependent (56%). CONCLUSIONS: The high incidence of ADRs because of treatment withdrawal revealed the need for safer alternatives for CD treatment.
DOI: 10.6084/m9.figshare.11756862.v1
title: Human platelet antigen-3 polymorphism as a risk factor for rheumatological manifestations in hepatitis C

description: Abstract INTRODUCTION: Hepatitis C virus (HCV) infection is involved in the pathogenesis of autoimmune and rheumatic disorders. Although the human platelet antigens (HPA) polymorphism are associated with HCV persistence, they have not been investigated in rheumatological manifestations (RM). This study focused on verifying associations between allele and genotype HPA and RM in patients with chronic hepatitis C. METHODS: Patients (159) with chronic hepatitis C of both genders were analyzed. RESULTS: Women showed association between HPA-3 polymorphisms and RM. CONCLUSIONS: An unprecedented strong association between rheumatological manifestations and HPA-3 polymorphism, possibly predisposing women to complications during the disease course, was observed.