cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6069/vvb1-k710
title: AD-BXD Mouse PreFrontal Cortex Proteomics

description: The AD-BXD mouse population is a powerful emerging model for studying AD resilience. AD-BXD mice query two different levels of genetic information: genometypes and genotypes. The genetically diverse BXD genometypes are a mosaic of the approximately 6 million segregating single nucleotide polymorphisms between C57BL/6J and DBA/2J mice. The transgenic genotype of the 5 times familial Alzheimer’s disease (5xFAD) transgene, which includes human APP carrying three pathogentic variants and human PSEN1 carrying two pathogenic, can be contrasted with non-transgenic control animals (Ntg). Reproducible BXD genometypes allow repeated measurement of the same mosaic genomes, a strategy that boosts the mappable heritability of genetic loci (cite ). This property facilitates QTL mapping of the relatively lower effect size variants that modify susceptibility to Alzheimer’s-like cognitive phenotypes in 5xFAD animals. Further, the same cognitive phenotype can be measured in both 5xFAD and Ntg mice within the same genometype. The ability to contrast a genometype’s performance with different AD genotypes facilitates the measurement of novel and interesting derived phenotypes based upon the property of trait correlation (cite ). Because of these properties, our lab has successfully leveraged AD-BXD mice to identify genetic modifiers of AD-related phenotypes in recent years.
We quantified resilience using a novel regression-based metric. We utilized this measure to map resilience to a locus, then leveraged proteomics data to identify a putative molecular mechanism for the genetic resilience factor. We found potential novel targets for AD by querying elements coregulated in trans to the putative molecular mechanism. Finally, we implicated differential expression of networked synaptic proteins as the likeliest downstream consequences of differences in resilience.
DOI: 10.17632/pddstg4gyz.1
title: Science Island dataset 2023

description: # Science Island goal analysis


Quantitative evaluation of emotional goals
Quantitative evaluation aims
The study collected quantitative data about the application of the right design method during the quest level development of the Science Island project. The right design method includes a coloured rating scale, as described in chapter five Figure 5.7. The quantitative data collection part of the study has three aims. Firstly, to evaluate whether the use of a numeric scale is effective at representing emotional goals, secondly to find out the benefits of rating emotional goals collectively and thirdly to investigate the translation of the emotional goal rating from a number into a visualisation.


Qualitative evaluation of emotional goals
Qualitative evaluation aims
The qualitative study had three aims. Firstly, to see whether collective intentionality formed through the goal rating process. Secondly, to find out how important the student developers thought emotional goals were in guiding their design outcomes. Thirdly, to see what level of focus the emotional goals received in relation to the other project goals and roles.  To elicit responses relevant to these aims, the following questions were asked by the lecturer, after the students had completed their rating of the project goals. 

Questions for aim one: How difficult was it to agree on a score? Did you all agree straight away or was there a lot of discussion?
Questions for aim two: How did the goals guide you with your development and design? Which ones and how?
Questions for aim three: Did you consider the emotional, quality, and functional goals separately and which of these types of goals were most relevant during the project development?



## Sharing/access Information
Towards Wonderful Design: Elements, Principles, Methods & Applications
Author: Marshall, James George

https://researchbank.swinburne.edu.au/items/104a6ce1-3475-48ee-9119-30a29bc69bb3/1/
DOI: 10.17632/crcjw5hnkj.1
title: Summary of Studies

description: Table 1, Summary of studies evaluating the effects of endurance training on cardiovascular and metabolic function.
DOI: 10.17632/5pgnmw827v.1
title: Experimental measurements on the natural carbonation depth of limestone powder concrete

description: This dataset contains experimental measurements of the natural carbonation depths within the scope of the ongoing PhD thesis 'STRUCTURAL CONCRETE WITH REDUCED CEMENT AND HIGH LIMESTONE POWDER CONTENT' and MSc thesis 'INFLUENCE OF CEMENT BEING REPLACED WITH LIMESTONE FILLER ON THE PROPERTIES OF CONCRETE', at the University of Belgrade's Faculty of Civil Engineering.
The dataset includes compressive strengths, natural carbonation depths, as well as ambient conditions, and test durations.
DOI: 10.17632/vphxkbkcx3.1
title: game meat dataset

description: This presents raw inferential statistical data to explore what pushes consumers to include game meat in their diet.The significance of rational motives related to the quality attributes of game meat for consumers (i.e. health benefits, availability, cost, meat safety, and production ethics) was analysed using statistical analysis based on the structural equation modelling using AMOS software, version 28. Reliability and validity were confirmed. The outcomes obtained from this dataset show the relationship between health benefits, availability, cost and production ethics had a positive and a significant impact on game meat consumption. However, food safety proved to have a negative and insignificant influence on actual game meat consumption.
DOI: 10.17632/vphxkbkcx3.2
title: game meat dataset

description: This presents raw inferential statistical data to explore what pushes consumers to include game meat in their diet.The significance of rational motives related to the quality attributes of game meat for consumers (i.e. health benefits, availability, cost, meat safety, and production ethics) was analysed using statistical analysis based on the structural equation modelling using AMOS software, version 28. Reliability and validity were confirmed. The outcomes obtained from this dataset show the relationship between health benefits, availability, cost and production ethics had a positive and a significant impact on game meat consumption. However, food safety proved to have a negative and insignificant influence on actual game meat consumption.
DOI: 10.17632/ycxy9jn87r.1
title: Microtopography-mediated hydrologic environment controls organic sulfur mineralization in soils of sub-tropical monsoon climate

description: Research data is related to: Microtopography-mediated hydrologic environment controls organic sulfur mineralization in soils of sub-tropical monsoon climate
DOI: 10.17632/gnbw3nmt69.1
title: Phase Separation of FOXA1 Unpacks the Condensed Chromatin to Function as a Pioneer Factor

description: Eukaryotic DNA is packaged into chromatin in the nucleus, which restricts the binding of transcription factors (TFs) to the target DNA sites. FOXA1 functions as a pioneer TF to bind condensed chromatin and initiate the opening of local chromatin for gene expression. However, the principles of how FOXA1 recruits to and unpacks the condensed chromatin remain elusive. Here, we revealed that FOXA1 intrinsically undergoes phase separation through its N- and C-terminal intrinsically disordered regions (IDRs). Notably, the property that allows FOXA1 to phase separate enables FOXA1 to dissolve the condensed chromatin. In addition, the DNA-binding capacity of FOXA1 contributes to its phase-separation property. Further genome-wide investigation showed that FOXA1 is recruited to and unpacks the condensed chromatin by its IDRs to regulate the proliferation and migration of breast cancer cells. This work provides a principle of how pioneer TFs function to initiate competent chromatin states by phase separation.
DOI: 10.17632/tbpb2hj3fn.1
title: Dataset and Codes used for "The line bisection bias stems from left-side underawareness, not from right-side hyperattention"

description: This folder contains the dataset of aptient and healthy participant data gathered for the aforementioned study. We examined whether the bias in line bisection displayed by many patients with visuospatial neglect is more in line with an underawareness of the left side of the line, or of hyperattention towards the right. To this end, we measures four groups: neglect patients with line bisection bias, neglect patients without line bisection bias, patients with a right-sided stroke without neglect, and healthy controls, in several tasks involving horizontal lines: Line bisection, a line 'segmentation task', two number line tasks, and a verbal number bisection task. For each line task, the number in the cell denotes where on the line the mark was placed in centimetres from the left (on a 20cm line). For example, if a cell says "0.9", the mark was placed 9mm from the left end of the line, if it says "12.2", it was placed 122mm from the left end of the line. Columns starting with "4T" denote individual marks of segmenting the line into 4 equal parts, "3T" individual trials of segmenting the line into 3 equal parts. the number following this (1-5) denotes the trial itself (there were up to 5 trials in total, if patients could do so many), and the number after "Prop" denotes whether it is the first, second or third line from the left. E.g., "4T2_Prop3" would denote: The third line from the left (i.e., the 3/4 line) of the second trial of the quarters segmentation task. The "fractions" number line task trials are denoted by the resepctive fraction followed by the trial (again, 1-5): For example, 1DIV3_2 denotes the second trial of marking "1/3". For the "whole numbers" number line task, the number following "BNL" denotes the number to mark, again followed by the respective trial ("BNL6_1" is the first trial of marking 6 on the line). Finally, all columns denoting the German words "Auf" and "Ab" denote number bisection trials where numbers were either said in an increasing order ("Auf") or decreasing order ("Ab"), whereby cells denote the number said by the participant for that trial. Finally, individual R codes were written for each task, as well as individual visualisation codes. The codes should be sufficiently commented and thus do not need furhter description here.
DOI: 10.17632/tbpb2hj3fn.2
title: Dataset and Codes used for "Number proportions" project

description: This folder contains a dataset of patient and healthy participant data gathered for studies examining proportional and numerical reasoning in neglect. We examined whether neurological patients with a deficit in line bisection specifically exhibit problems in bisecting a line into two equal parts or whether this deficit is based on a more general problem that also affects the representation of, e.g., thirds or fourths. To this end, we measured four groups: neglect patients with line bisection bias, neglect patients without line bisection bias, patients with a right-sided stroke without neglect, and healthy controls, in several tasks involving horizontal lines: Line bisection, a line 'segmentation task', two number line tasks, and a verbal number bisection task. For each line task, the number in the cell denotes where on the line the mark was placed in centimetres from the left (on a 20cm line). For example, if a cell says "0.9", the mark was placed 9mm from the left end of the line, if it says "12.2", it was placed 122mm from the left end of the line. Columns starting with "4T" denote individual marks of segmenting the line into 4 equal parts, "3T" individual trials of segmenting the line into 3 equal parts. the number following this (1-5) denotes the trial itself (there were up to 5 trials in total, if patients could do so many), and the number after "Prop" denotes whether it is the first, second or third line from the left. E.g., "4T2_Prop3" would denote: The third line from the left (i.e., the 3/4 line) of the second trial of the quarters segmentation task. The "fractions" number line task trials are denoted by the resepctive fraction followed by the trial (again, 1-5): For example, 1DIV3_2 denotes the second trial of marking "1/3". For the "whole numbers" number line task, the number following "BNL" denotes the number to mark, again followed by the respective trial ("BNL6_1" is the first trial of marking 6 on the line). Finally, all columns denoting the German words "Auf" and "Ab" denote number bisection trials where numbers were either said in an increasing order ("Auf") or decreasing order ("Ab"), whereby cells denote the number said by the participant for that trial. Finally, individual R codes were written for each task, as well as individual visualisation codes. The codes should be sufficiently commented and thus do not need further description here.
DOI: 10.17632/b5n4jphtmr.1
title: Data for: Empirical evidence on discrimination in multi-technology renewable energy auctions in Europe

description: Data accompanying the submission "Empirical evidence on discrimination in multi-technology renewable energy auctions in Europe" by Julius Buschle, Vasilios Anatolitis, and Patrick Plötz to the journal "Energy Policy". We conducted a fractional logit regression to empirically measure the impact of various auction design elements on the success rates of two technologies, solar PV and onshore wind, in multi-technology renewable energy auctions, based on data from 57 auction rounds from 2011 – 2021 in Europe.

Here, you can find the following data:
1. R-code for the curation of data and the regression analysis
2. Renewable energy shares in European countries (based on data from Eurostat and own interpolation) for control variables
3. Data on European auctions (based on AURES II Auction Database) for dependent and explanatory variables
DOI: 10.17909/5rss-xs54
title: HST data for Sarbadhicary+2023

description: Images used for Fig 1
DOI: 10.6084/m9.figshare.24145071
title: Supplementary Material for: IMMUNOHISTOCHEMISTRY, MOLECULAR BIOLOGY AND CLINICAL SCORING FOR THE DETECTION OF MUIR-TORRE SYNDROME IN CUTANEOUS SEBACEOUS TUMORS: WHICH STRATEGY?

description: Background Sebaceous neoplasms (SNs) always raise the possibility of an association with Muir-Torre syndrome (MTS) and permit to screen internal malignancies, colorectal and endometrial carcinomas, before they become symptomatic. Immunohistochemistry (IHC), molecular biology and clinical examination are different approaches for detection of MTS. We conducted a retrospective analysis of non-selected SNs in order to determine the optimal tools to implement for MTS screening. Methods Deficient MMR phenotype (dMMR) was determined by either IHC using antibodies directed to four mismatch repair (MMR) antigens on tissue-microarray or molecular biology using pentaplex PCR. The Mayo-Clinic-Risk score of MTS was calculated from medical records. Sensibility and specificity of each test for the detection of MTS was determined. Results We included 107 patients, 8 with multiple SNs, for a total of 123 SNs (43 sebaceous adenomas, 19 sebaceomas and 61 sebaceous carcinomas (SC)). Loss of at least one MMR protein was observed in 70.7% of tumors while 48% had a microsatellite instable phenotype. Concordance between both techniques was 92.9%, with a 0.85 Cohen’s kappa coefficient. Nineteen patients (20.2%) had a ≥2 points Mayo-Clinic-Risk-Score, one having a pMMR SC. Among the 13 patients with confirmed MTS, 2 had a low Mayo-Clinic-risk score (1 point). IHC had the highest sensitivity for MTS screening (100%) with a specificity of 34.1% while a &gt;2 points Mayo-Clinic-Risk-Score had a lower sensitivity (92%) but a higher specificity (89%). Conclusion To detect MTS in SNs patients, first line Mayo-Clinic-risk-score followed by IHC appears the most accurate strategy with lower cost for society. This strategy should be adapted to the medico-economic resources of each country.
DOI: 10.6084/m9.figshare.24145071.v1
title: Supplementary Material for: IMMUNOHISTOCHEMISTRY, MOLECULAR BIOLOGY AND CLINICAL SCORING FOR THE DETECTION OF MUIR-TORRE SYNDROME IN CUTANEOUS SEBACEOUS TUMORS: WHICH STRATEGY?

description: Background Sebaceous neoplasms (SNs) always raise the possibility of an association with Muir-Torre syndrome (MTS) and permit to screen internal malignancies, colorectal and endometrial carcinomas, before they become symptomatic. Immunohistochemistry (IHC), molecular biology and clinical examination are different approaches for detection of MTS. We conducted a retrospective analysis of non-selected SNs in order to determine the optimal tools to implement for MTS screening. Methods Deficient MMR phenotype (dMMR) was determined by either IHC using antibodies directed to four mismatch repair (MMR) antigens on tissue-microarray or molecular biology using pentaplex PCR. The Mayo-Clinic-Risk score of MTS was calculated from medical records. Sensibility and specificity of each test for the detection of MTS was determined. Results We included 107 patients, 8 with multiple SNs, for a total of 123 SNs (43 sebaceous adenomas, 19 sebaceomas and 61 sebaceous carcinomas (SC)). Loss of at least one MMR protein was observed in 70.7% of tumors while 48% had a microsatellite instable phenotype. Concordance between both techniques was 92.9%, with a 0.85 Cohen’s kappa coefficient. Nineteen patients (20.2%) had a ≥2 points Mayo-Clinic-Risk-Score, one having a pMMR SC. Among the 13 patients with confirmed MTS, 2 had a low Mayo-Clinic-risk score (1 point). IHC had the highest sensitivity for MTS screening (100%) with a specificity of 34.1% while a &gt;2 points Mayo-Clinic-Risk-Score had a lower sensitivity (92%) but a higher specificity (89%). Conclusion To detect MTS in SNs patients, first line Mayo-Clinic-risk-score followed by IHC appears the most accurate strategy with lower cost for society. This strategy should be adapted to the medico-economic resources of each country.
DOI: 10.6084/m9.figshare.24145116
title: Supplementary Material for: Irisin ameliorated skeletal muscle atrophy by inhibiting fatty acid oxidation and pyroptosis induced by palmitic acid in chronic kidney disease

description: Introduction:Protein-energy waste (PEW) is a common complication in patients with chronic kidney disease (CKD), among which skeletal muscle atrophy is one of the most important clinical features of PEW. Pyroptosis is a type of proinflammatory programmed cell death associated with skeletal muscle disease. Irisin, as a novel myokine, has attracted extensive attention for its protective role in the complications associated with CKD, but its role in muscle atrophy in CKD is unclear.Methods:Palmitic acid (PA) induced muscular atrophy was evaluated by a reduction in C2C12 myotube diameter. Muscle atrophy model was established in male C57BL/6J mice treated with 0.2% adenine for 4 weeks and then fed a 45% high-fat diet.BUN and Cr levels ,body and muscle weight, and muscle histology were assessed. The expression of carnitine palmitoyltransferase 1A (CPT1A) and pyroptosis-related protein was analysed by western blots or immunohistochemistry. The release of IL-1β was detected by ELISA.Results:In this study, we showed that PA induced muscular atrophy and manifested as a reduction in C2C12 myotube diameter. During this process PA can also induce pyroptosis, as shown by the upregulation of NLRP3, cleaved Caspase1 and GSDMD-N expression and the increased IL-1β release and PI-positive cell rate. Inhibition of Caspase1 or NLRP3 attenuated PA-induced pyroptosis and myotube atrophy in C2C12 cells. Importantly, Irisin treatment significantly ameliorated PA-induced skeletal muscle pyroptosis and atrophy. In terms of mechanism, PA upregulated CPT1A, a key enzyme of fatty acid oxidation(FAO), and Irisin attenuated this effect, which was consistent with Etomoxir (CPT1A inhibitor) treatment. Moreover, Irisin improved skeletal muscle atrophy and pyroptosis in adenine-induced mice by regulating FAO. Conclusion: our study firstly verifies that pyroptosis is a novel mechanism of skeletal muscle atrophy in CKD. Irisin ameliorated skeletal muscle atrophy by inhibiting FAO and pyroptosis in CKD, and Irisin may be developed as a potential therapeutic agent for the treatment of muscle wasting in CKD patients.
DOI: 10.6084/m9.figshare.24145116.v1
title: Supplementary Material for: Irisin ameliorated skeletal muscle atrophy by inhibiting fatty acid oxidation and pyroptosis induced by palmitic acid in chronic kidney disease

description: Introduction:Protein-energy waste (PEW) is a common complication in patients with chronic kidney disease (CKD), among which skeletal muscle atrophy is one of the most important clinical features of PEW. Pyroptosis is a type of proinflammatory programmed cell death associated with skeletal muscle disease. Irisin, as a novel myokine, has attracted extensive attention for its protective role in the complications associated with CKD, but its role in muscle atrophy in CKD is unclear.Methods:Palmitic acid (PA) induced muscular atrophy was evaluated by a reduction in C2C12 myotube diameter. Muscle atrophy model was established in male C57BL/6J mice treated with 0.2% adenine for 4 weeks and then fed a 45% high-fat diet.BUN and Cr levels ,body and muscle weight, and muscle histology were assessed. The expression of carnitine palmitoyltransferase 1A (CPT1A) and pyroptosis-related protein was analysed by western blots or immunohistochemistry. The release of IL-1β was detected by ELISA.Results:In this study, we showed that PA induced muscular atrophy and manifested as a reduction in C2C12 myotube diameter. During this process PA can also induce pyroptosis, as shown by the upregulation of NLRP3, cleaved Caspase1 and GSDMD-N expression and the increased IL-1β release and PI-positive cell rate. Inhibition of Caspase1 or NLRP3 attenuated PA-induced pyroptosis and myotube atrophy in C2C12 cells. Importantly, Irisin treatment significantly ameliorated PA-induced skeletal muscle pyroptosis and atrophy. In terms of mechanism, PA upregulated CPT1A, a key enzyme of fatty acid oxidation(FAO), and Irisin attenuated this effect, which was consistent with Etomoxir (CPT1A inhibitor) treatment. Moreover, Irisin improved skeletal muscle atrophy and pyroptosis in adenine-induced mice by regulating FAO. Conclusion: our study firstly verifies that pyroptosis is a novel mechanism of skeletal muscle atrophy in CKD. Irisin ameliorated skeletal muscle atrophy by inhibiting FAO and pyroptosis in CKD, and Irisin may be developed as a potential therapeutic agent for the treatment of muscle wasting in CKD patients.