cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.12880271
title: Additional file of Transcriptome dynamics and molecular cross-talk between bovine oocyte and its companion cumulus cells

description: Additional file of Transcriptome dynamics and molecular cross-talk between bovine oocyte and its companion cumulus cells
DOI: 10.6084/m9.figshare.7944281.v1
title: Supplementary Material for: Circulating Microparticles in Patients with Symptomatic Carotid Disease Are Related to Embolic Plaque Activity and Recent Cerebral Ischaemia

description: <b><i>Background and Purpose:</i></b> In order to assess the association of microparticles derived from activated platelets (PMP) or endothelial cells (EMP) with risk markers for recurrent embolic events in patients with symptomatic carotid artery disease, we studied the associations between PMP/EMP and three risk markers: plaque haemorrhage (PH), micro-embolic signals and cerebral diffusion abnormalities. <b><i>Methods:</i></b> Patients with recently symptomatic high-grade carotid artery stenosis (60–99%, 42 patients, 31 men; mean age 75 ± 8 years) and 30 healthy volunteers (HV, 11 men; mean age 56 ± 12 years) were prospectively recruited. Patients were characterised by carotid magnetic resonance imaging (presence of PH [MRI PH]), brain diffusion MRI (cerebral ischaemia [DWI+]) and transcranial Doppler ultrasound (micro-embolic signals [MES+]). PMP and EMP were classified by flow cytometry and expressed as log-transformed counts per microlitre. <b><i>Results:</i></b> MES+ patients (<i>n</i> = 18) had elevated PMP (MES+ 9.61 ± 0.57) compared to HV (8.80 ± 0.73; <i>p</i> &lt; 0.0001) and to MES– patients (8.55 ± 0.85; <i>p</i> &lt; 0.0001). Stroke patients had elevated PMP (9.49 ± 0.64) and EMP (6.13 ± 1.0) compared to non-stroke patients (PMP 8.81 ± 0.73, <i>p</i> = 0.026, EMP 5.52 ± 0.65, <i>p</i> = 0.011) and HV (PMP 8.80 ± 0.73, <i>p</i> = 0.007, and EMP 5.44 ± 0.47, <i>p</i> = 0.006). DWI+ patients (<i>n</i> = 16) showed elevated PMP (DWI+ 9.53 ± 0.64; vs. HV, <i>p</i> = 0.002) and EMP (DWI+ 5.91 ± 0.99 vs. HV 5.44 ± 0.47; <i>p</i> = 0.037). Only PMP but not EMP were higher in DWI+ versus DWI– patients (8.67 ± 0.90; <i>p</i> = 0.002). No association was found between PMP and EMP with MRI PH. <b><i>Conclusions:</i></b> PMP and EMP were associated with stroke and recent cerebrovascular events (DWI+) but only PMP were also associated with ongoing (MES+) thrombo-embolic activity suggesting a differential biomarker potential for EMP to index cerebral ischaemia while PMP may predict on-going thrombo-embolic activity.
DOI: 10.6084/m9.figshare.12880271.v45
title: Additional file of Transcriptome dynamics and molecular cross-talk between bovine oocyte and its companion cumulus cells

description: Additional file of Transcriptome dynamics and molecular cross-talk between bovine oocyte and its companion cumulus cells
DOI: 10.6084/m9.figshare.12880280.v1
title: Additional file 12 of Transcriptome dynamics and molecular cross-talk between bovine oocyte and its companion cumulus cells

description: Additional file 12:List of transcripts that are differentially expressed between oocytes cultured with or without their companion CCs. (XLS 68 KB)
DOI: 10.6084/m9.figshare.12880295.v1
title: Additional file 17 of Transcriptome dynamics and molecular cross-talk between bovine oocyte and its companion cumulus cells

description: Additional file 17:List of transcripts that are exclusively expressed in MII CCs compared with GV CCs. (XLS 116 KB)
DOI: 10.6084/m9.figshare.7944260
title: gVCF_NA18501

description: 1000 Genomes gVCF mapped to hs37d5 for NA18501. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7944266
title: Data µCT.xlsx

description: µCT measurements of fissures in equine cheek teeth
DOI: 10.6084/m9.figshare.7944269
title: gVCF_NA20783

description: 1000 Genomes gVCF mapped to hs37d5 for NA20783. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.12880292
title: Additional file 16 of Transcriptome dynamics and molecular cross-talk between bovine oocyte and its companion cumulus cells

description: Additional file 16:List of transcripts that are exclusively expressed in GV CCs compared to MII CCs. (XLS 563 KB)
DOI: 10.6084/m9.figshare.12880292.v1
title: Additional file 16 of Transcriptome dynamics and molecular cross-talk between bovine oocyte and its companion cumulus cells

description: Additional file 16:List of transcripts that are exclusively expressed in GV CCs compared to MII CCs. (XLS 563 KB)
DOI: 10.6084/m9.figshare.12880271.v44
title: Additional file of Transcriptome dynamics and molecular cross-talk between bovine oocyte and its companion cumulus cells

description: Additional file of Transcriptome dynamics and molecular cross-talk between bovine oocyte and its companion cumulus cells
DOI: 10.6084/m9.figshare.12880283.v1
title: Additional file 13 of Transcriptome dynamics and molecular cross-talk between bovine oocyte and its companion cumulus cells

description: Additional file 13:List of transcripts that are differentially expressed between CCs cultured with or without their oocyte. (XLS 120 KB)
DOI: 10.6084/m9.figshare.12880295
title: Additional file 17 of Transcriptome dynamics and molecular cross-talk between bovine oocyte and its companion cumulus cells

description: Additional file 17:List of transcripts that are exclusively expressed in MII CCs compared with GV CCs. (XLS 116 KB)
DOI: 10.6084/m9.figshare.12880298
title: Additional file 18 of Transcriptome dynamics and molecular cross-talk between bovine oocyte and its companion cumulus cells

description: Additional file 18:List of transcripts that are commonly expressed between CCs at GV and MII stages. (XLS 884 KB)
DOI: 10.6084/m9.figshare.12880301
title: Additional file 19 of Transcriptome dynamics and molecular cross-talk between bovine oocyte and its companion cumulus cells

description: Additional file 19:List of transcripts that are differentially expressed between GV and MII CCs. (XLS 870 KB)
DOI: 10.6084/m9.figshare.7944260.v1
title: gVCF_NA18501

description: 1000 Genomes gVCF mapped to hs37d5 for NA18501. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.12880298.v1
title: Additional file 18 of Transcriptome dynamics and molecular cross-talk between bovine oocyte and its companion cumulus cells

description: Additional file 18:List of transcripts that are commonly expressed between CCs at GV and MII stages. (XLS 884 KB)
DOI: 10.6084/m9.figshare.7944269.v1
title: gVCF_NA20783

description: 1000 Genomes gVCF mapped to hs37d5 for NA20783. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.12880283
title: Additional file 13 of Transcriptome dynamics and molecular cross-talk between bovine oocyte and its companion cumulus cells

description: Additional file 13:List of transcripts that are differentially expressed between CCs cultured with or without their oocyte. (XLS 120 KB)
DOI: 10.6084/m9.figshare.12880340.v1
title: Additional file 2 of Transcriptome dynamics and molecular cross-talk between bovine oocyte and its companion cumulus cells

description: Additional file 2:List of transcripts that are exclusively expressed in GV oocytes relative to GV CCs. (XLS 198 KB)
DOI: 10.6084/m9.figshare.12880301.v1
title: Additional file 19 of Transcriptome dynamics and molecular cross-talk between bovine oocyte and its companion cumulus cells

description: Additional file 19:List of transcripts that are differentially expressed between GV and MII CCs. (XLS 870 KB)
DOI: 10.6084/m9.figshare.7944266.v1
title: Data µCT.xlsx

description: µCT measurements of fissures in equine cheek teeth
DOI: 10.6084/m9.figshare.12593657
title: An Algorithmic Approach to Determine Expertise Development using Object Related Gaze Pattern Sequences

description: Dataset for the conducted learning behavior Eye Tracking Study.The data set contains several data forms:"ET Fixation Data" for group experts, group BiColor (BC) and group MultiColor (MC). Data is given in the form of AOI lists, where each fixation is assigned to a task AOI. Additionally the fixation start, end and duration is given. These lists are also provided as converted string sequences, where each character is uniquely assigned to an AOI. For the analysis in the research article, successive appearances of the same character are summarized into one character.<br>"Pattern Frequency" contains the appearing k-mer patterns for each study subject in each trial as .mat struct file (MATLAB).<br>
DOI: 10.6084/m9.figshare.12880340
title: Additional file 2 of Transcriptome dynamics and molecular cross-talk between bovine oocyte and its companion cumulus cells

description: Additional file 2:List of transcripts that are exclusively expressed in GV oocytes relative to GV CCs. (XLS 198 KB)
DOI: 10.6084/m9.figshare.7944224
title: Supplementary Material for: High-Sensitivity C-Reactive Protein and Allergic Endpoints in German Adolescents

description: <b><i>Background:</i></b> Assessing high-sensitivity C-reactive protein (hs-CRP) in relation to allergic endpoints can shed light on both the mechanisms of allergic disease development and early non-communicable disease prevention. However, only a few epidemiological studies so far have investigated the relationship in children and adolescents, and the results were mixed. <b><i>Objectives:</i></b> We sought to examine the interrelation between hs-CRP levels and allergic outcomes using a larger population size and a longitudinal study design. <b><i>Methods:</i></b> Complete data were available on 1,955 participants from the 15-years follow-up of the 2 large population-based German birth cohorts – GINIplus and LISA. Serum hs-CRP concentrations were measured using the immunoturbidimetric high-sensitive assay. Six allergic endpoints were used – doctor-diagnosed asthma, doctor-diagnosed eczema, doctor-diagnosed allergic rhinitis, food sensitization, aeroallergen sensitization, and any sensitization. We used generalized estimation equation models<sup></sup> to assess the associations between hs-CRP levels and allergic endpoints. <b><i>Results:</i></b> Our longitudinal analyses did not detect any significant association between hs-CRP levels and any of the studied allergic outcomes (e.g., asthma, eczema, allergic rhinitis, food sensitization, aeroallergen sensitization, and any sensitization). The results were consistent in a series of sensitivity analyses. <b><i>Conclusions:</i></b> Our study suggests that there is no association between hs-CRP levels and any of the allergic endpoints in German adolescents. However, whether allergic diseases are inflammatory conditions and which markers might be most sensitive, remain to be confirmed in future studies.
DOI: 10.6084/m9.figshare.7944233
title: gVCF_NA20778

description: 1000 Genomes gVCF mapped to hs37d5 for NA20778. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7944230
title: Supplementary Material for: Assessment of CYP2C9, CYP2C19, and CYP2D6 Polymorphisms in Allergic Patients with Chemical Sensitivity

description: <b><i>Background:</i></b> Self-reported chemical sensitivity (SCS) is characterized by adverse effects due to exposure to low levels of chemical substances. The clinical manifestations of SCS are similar to the allergy, and a high percentage of individuals with both diseases have been found. Various genes, especially genes of importance to the metabolism of xenobiotic compounds, have been associated with SCS. <b><i>Objectives:</i></b> The purpose of this study was to investigate whether allergic individuals with chemical sensitivity differed from allergic patients without chemical sensitivity with regard to the distribution of genotype and phenotype of <i>CYP2C9</i>, <i>CYP2C19</i>, and <i>CYP2D6</i> polymorphisms. <b><i>Methods:</i></b> A total of 180 patients were enrolled for this study. A questionnaire was employed to collect information on individual chemical sensitivity, while the Skin prick test and the PATCH test were used to verify the presence of an allergic condition against inhalants or contact allergens, respectively. For the evaluation of the <i>CYP2C9</i>, <i>CYP2C19</i>, and <i>CYP2D6</i> polymorphisms, we used a strategy based on the amplification of the entire gene coupled to direct genomic DNA sequencing analysis. <b><i>Results:</i></b> Overall, a total of 15 different <i>CYP2C9</i>, <i>CYP2C19</i>, and <i>CYP2D6</i> haplotypes were identified in our population. If the 5 <i>CYP2C9</i> and the 2 <i>CYP2C19</i> identified alleles correspond to the previously described ones, 4 of the 8 <i>CYP2D6</i> haplotypes, detected in the study group, present new SNPs combinations. These new suballeles were categorized as <i>CYP2D6</i>*<i>2M</i> Sa­lento Variant 1, <i>CYP2D6</i>*<i>35B</i> Salento Variant 2, <i>CYP2D6</i>*<i>41</i> Salento Variant 3, and <i>CYP2D6</i>*<i>4P</i> Salento Variant 4 due to the presence of the key SNPs 2,850 C&gt;T, 31G&gt;A, 2,988 G&gt;A, and 1,846 G&gt;A, respectively. When the allergic individuals are divided into 2 groups according to their SCS score, we observed that the distribution of the<i> CYP2D6</i> phenotypes was significantly different between the 2 groups. <b><i>Conclusions:</i></b> Our idea is that the application of the questionnaire that we have adopted has enabled us to diagnose a degree of chemical sensitivity, which results as comorbid of the allergic disease and in which a condition of poor or intermediate metabolizes for the detrimental <i>CYP2D6</i> alleles, could represent a discriminant between the chemical sensitivity and the health state.
DOI: 10.6084/m9.figshare.12880376
title: Additional file 3 of Transcriptome dynamics and molecular cross-talk between bovine oocyte and its companion cumulus cells

description: Additional file 3:List of transcripts that are exclusively expressed in GV CCs relative to GV oocytes. (XLS 315 KB)
DOI: 10.6084/m9.figshare.12880376.v1
title: Additional file 3 of Transcriptome dynamics and molecular cross-talk between bovine oocyte and its companion cumulus cells

description: Additional file 3:List of transcripts that are exclusively expressed in GV CCs relative to GV oocytes. (XLS 315 KB)
DOI: 10.6084/m9.figshare.12880403.v1
title: Additional file 6 of Transcriptome dynamics and molecular cross-talk between bovine oocyte and its companion cumulus cells

description: Additional file 6:List of transcripts that are expressed in both MII oocytes and CCs. (XLS 366 KB)
DOI: 10.6084/m9.figshare.12880406.v1
title: Additional file 7 of Transcriptome dynamics and molecular cross-talk between bovine oocyte and its companion cumulus cells

description: Additional file 7:List of transcripts that are differentially expressed between GV oocytes and CCs. (XLS 1 MB)
DOI: 10.6084/m9.figshare.12880406
title: Additional file 7 of Transcriptome dynamics and molecular cross-talk between bovine oocyte and its companion cumulus cells

description: Additional file 7:List of transcripts that are differentially expressed between GV oocytes and CCs. (XLS 1 MB)
DOI: 10.6084/m9.figshare.7944230.v1
title: Supplementary Material for: Assessment of CYP2C9, CYP2C19, and CYP2D6 Polymorphisms in Allergic Patients with Chemical Sensitivity

description: <b><i>Background:</i></b> Self-reported chemical sensitivity (SCS) is characterized by adverse effects due to exposure to low levels of chemical substances. The clinical manifestations of SCS are similar to the allergy, and a high percentage of individuals with both diseases have been found. Various genes, especially genes of importance to the metabolism of xenobiotic compounds, have been associated with SCS. <b><i>Objectives:</i></b> The purpose of this study was to investigate whether allergic individuals with chemical sensitivity differed from allergic patients without chemical sensitivity with regard to the distribution of genotype and phenotype of <i>CYP2C9</i>, <i>CYP2C19</i>, and <i>CYP2D6</i> polymorphisms. <b><i>Methods:</i></b> A total of 180 patients were enrolled for this study. A questionnaire was employed to collect information on individual chemical sensitivity, while the Skin prick test and the PATCH test were used to verify the presence of an allergic condition against inhalants or contact allergens, respectively. For the evaluation of the <i>CYP2C9</i>, <i>CYP2C19</i>, and <i>CYP2D6</i> polymorphisms, we used a strategy based on the amplification of the entire gene coupled to direct genomic DNA sequencing analysis. <b><i>Results:</i></b> Overall, a total of 15 different <i>CYP2C9</i>, <i>CYP2C19</i>, and <i>CYP2D6</i> haplotypes were identified in our population. If the 5 <i>CYP2C9</i> and the 2 <i>CYP2C19</i> identified alleles correspond to the previously described ones, 4 of the 8 <i>CYP2D6</i> haplotypes, detected in the study group, present new SNPs combinations. These new suballeles were categorized as <i>CYP2D6</i>*<i>2M</i> Sa­lento Variant 1, <i>CYP2D6</i>*<i>35B</i> Salento Variant 2, <i>CYP2D6</i>*<i>41</i> Salento Variant 3, and <i>CYP2D6</i>*<i>4P</i> Salento Variant 4 due to the presence of the key SNPs 2,850 C&gt;T, 31G&gt;A, 2,988 G&gt;A, and 1,846 G&gt;A, respectively. When the allergic individuals are divided into 2 groups according to their SCS score, we observed that the distribution of the<i> CYP2D6</i> phenotypes was significantly different between the 2 groups. <b><i>Conclusions:</i></b> Our idea is that the application of the questionnaire that we have adopted has enabled us to diagnose a degree of chemical sensitivity, which results as comorbid of the allergic disease and in which a condition of poor or intermediate metabolizes for the detrimental <i>CYP2D6</i> alleles, could represent a discriminant between the chemical sensitivity and the health state.
DOI: 10.6084/m9.figshare.7944212
title: gVCF_NA20775

description: 1000 Genomes gVCF mapped to hs37d5 for NA20775. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7944233.v1
title: gVCF_NA20778

description: 1000 Genomes gVCF mapped to hs37d5 for NA20778. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.12880400.v1
title: Additional file 5 of Transcriptome dynamics and molecular cross-talk between bovine oocyte and its companion cumulus cells

description: Additional file 5:List of transcripts that are expressed only MII CCs. (XLS 186 KB)
DOI: 10.6084/m9.figshare.12880403
title: Additional file 6 of Transcriptome dynamics and molecular cross-talk between bovine oocyte and its companion cumulus cells

description: Additional file 6:List of transcripts that are expressed in both MII oocytes and CCs. (XLS 366 KB)
DOI: 10.6084/m9.figshare.12880409
title: Additional file 8 of Transcriptome dynamics and molecular cross-talk between bovine oocyte and its companion cumulus cells

description: Additional file 8:List of transcripts that are expressed only in MII oocytes. (XLS 2 MB)
DOI: 10.6084/m9.figshare.7944218
title: gVCF_NA18499

description: 1000 Genomes gVCF mapped to hs37d5 for NA18499. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.12880400
title: Additional file 5 of Transcriptome dynamics and molecular cross-talk between bovine oocyte and its companion cumulus cells

description: Additional file 5:List of transcripts that are expressed only MII CCs. (XLS 186 KB)
DOI: 10.6084/m9.figshare.12880412.v1
title: Additional file 9 of Transcriptome dynamics and molecular cross-talk between bovine oocyte and its companion cumulus cells

description: Additional file 9:List of transcripts that are differentially expressed between MII oocytes and CCs. (XLS 2 MB)
DOI: 10.6084/m9.figshare.12880397
title: Additional file 4 of Transcriptome dynamics and molecular cross-talk between bovine oocyte and its companion cumulus cells

description: Additional file 4:List of transcripts that are expressed in both GV oocytes and CCs. (XLS 1 MB)
DOI: 10.6084/m9.figshare.12880397.v1
title: Additional file 4 of Transcriptome dynamics and molecular cross-talk between bovine oocyte and its companion cumulus cells

description: Additional file 4:List of transcripts that are expressed in both GV oocytes and CCs. (XLS 1 MB)
DOI: 10.6084/m9.figshare.12880409.v1
title: Additional file 8 of Transcriptome dynamics and molecular cross-talk between bovine oocyte and its companion cumulus cells

description: Additional file 8:List of transcripts that are expressed only in MII oocytes. (XLS 2 MB)
DOI: 10.6084/m9.figshare.7944206
title: Open Science Community on Google Plus — Posts, Members, Moderators, etc.

description: Archive of the Open Science Community on Google's former social network, Google Plus. To browse links to file content, the archive must be fully extracted or unzipped.<br>Topics the community had addressed included: open access publishing, open source software, open standards, open data, open notebook science, open educational resources, citizen science, and equity in all forms, for both practicing and advocating for Open Science.<br>The community operated from the first to the last day that Google Plus had offered its bulletin board-like "Community" feature, from 6 December 2012 to 2 April 2019. There were, at its peak roughly 40,000 members of the community and a couple dozen moderators. Some moderators are named in this archive while others are anonymous or pseudonymous; all worked pro bono and the community was not otherwise funded nor sponsored. It was managed by the Open Science Federation, a nonprofit, civil society organization which also operates @openscience on Twitter, web hosting, and other services, and generally conducts activities to effect and advocate for Open Science.
DOI: 10.6084/m9.figshare.7944209
title: gVCF_NA18498

description: 1000 Genomes gVCF mapped to hs37d5 for NA18498. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7944212.v1
title: gVCF_NA20775

description: 1000 Genomes gVCF mapped to hs37d5 for NA20775. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7944218.v1
title: gVCF_NA18499

description: 1000 Genomes gVCF mapped to hs37d5 for NA18499. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7944197
title: TSP1 and TSP2 deficiencies affect LOX protein distribution in the femoral diaphysis and pro-peptide removal in marrow-derived mesenchymal stem cells in vitro

description: Thrombospondin-1 and 2 have each been implicated in collagen fibrillogenesis. We addressed the possibility that deficits in lysyl oxidase (LOX) contribute to the extracellular matrix (ECM) phenotype of TSP-deficient bone. We examined detergent insoluble (mature cross-linked) and soluble (newly secreted) ECM fractions prepared from diaphyseal cortical bone. Detergent-insoluble hydroxyproline content, an indicator of cross-linked collagen content and LOX function, was reduced in female TSP-deficient bones. In male diaphyses, only TSP2 deficiency affected insoluble hydroxyproline content. Western blot suggested that removal of the LOX-pro-peptide (LOPP), an indication of LOX activation, was not affected by TSP status. Instead, the distribution of pro-LOX and mature LOX between immature and mature ECM was altered by TSP-status. LOX was also examined in primary marrow-derived mesenchymal stem cells (MSC) treated with ascorbate. Relative LOPP levels were elevated compared to WT in MSC conditioned medium from female TSP-deficient mice. When cells were serum starved to limit LOX pro-peptide removal, pro-LOX levels were elevated in TSP2-/- cells compared to wild-type. This phenotype was associated with a transient increase in BMP1 levels in TSP2-/- conditioned medium. TSP2 was detected in bone tissue and osteoblast cell culture. TSP1 was only detected in insoluble ECM prepared from WT diaphyseal bone samples. Our data suggest that the trimeric thrombospondins contribute to bone matrix quality by regulating the distribution of pro and mature LOX between newly secreted, immature ECM and mature, cross-linked ECM.