cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.12850373.v1
title: The risk factors for delayed bleeding after endoscopic resection of colorectal tumors: a meta-analysis

description: The most common complication of post-colorectal endoscopic resection is delayed bleeding. The assessment of risk factors for delayed bleeding provides important and useful information in standard clinical operations. The risk factors have been previously reported; however, they remain inconsistent across different studies. In this meta-analysis, the patient conditions, lesion-related factors, and operation-related factors were compared between delayed bleeding and no bleeding. PubMed, Cochrane, Embase, China National Knowledge Infrastructure (CNKI), and Wanfang Database were searched to identify eligible studies. Pooled odds ratio (OR) and 95% confidence intervals (CI) were calculated along with heterogeneity. This study is the first meta-analysis to investigate risk factors for colorectal delayed bleeding. We found several risk factors contributing to this condition: colorectal tumors located in the proximal colon, a history of antithrombotic drug use, high-grade intraepithelial neoplasia or early cancer, piecemeal resection, intraoperative hemorrhage, no clip placement, and severe submucosal fibrosis. Despite our findings, we also conclude that more high-quality, large-scale clinical randomized controlled studies are needed due to limited retrospective studies at present. Future therapeutic colonoscopies should focus on precise diagnosis, treatment safety, and management during the perioperative period.
DOI: 10.6084/m9.figshare.18093158.v1
title: Additional file 2 of Iodine-125 seed represses the growth and facilitates the apoptosis of colorectal cancer cells by suppressing the methylation of miR-615 promoter

description: Additional file 2..
DOI: 10.6084/m9.figshare.18093161
title: Additional file 3 of Iodine-125 seed represses the growth and facilitates the apoptosis of colorectal cancer cells by suppressing the methylation of miR-615 promoter

description: Additional file 3..
DOI: 10.6084/m9.figshare.18093161.v1
title: Additional file 3 of Iodine-125 seed represses the growth and facilitates the apoptosis of colorectal cancer cells by suppressing the methylation of miR-615 promoter

description: Additional file 3..
DOI: 10.6084/m9.figshare.18093164
title: Additional file 4 of Iodine-125 seed represses the growth and facilitates the apoptosis of colorectal cancer cells by suppressing the methylation of miR-615 promoter

description: Additional file 4..
DOI: 10.6084/m9.figshare.18093256
title: Surgical treatment of macrodactyly of the foot in children

description: The purpose of the study was to produce an algorithm and surgical procedure for optimum treatment of pedal macrodactyly. Surgery was performed on 27 feet of 26 patients with a mean age of 33 months at the time of surgery (range: 7–108 months). A multi-technique procedure based on the involved elements of the foot (soft tissue, phalanx, or metatarsal, or a combination of these) was adopted. The intermetatarsal width ratio, phalanx spread angle, and metatarsal spread angle was used to evaluate the severity of the macrodactyly and the effect of treatment. The Oxford Ankle Foot Questionnaire for Children and the Questionnaire for Foot Macrodactyly were employed to evaluate the clinical results. Under the guidelines of the treatment algorithm, all patients were successfully operated on using the multi-technique procedure; the sizes of the affected feet decreased significantly. After a mean of 33 months (range: 18–42 months) follow-up, the intermetatarsal width ratio decreased from 1.13 to 0.93 (<i>p</i> &lt; 0.05), the phalanx spread angle decreased from 31.3° to 17.9° (<i>p</i> &lt; 0.05), the metatarsal spread angle decreased from 33.2° to 15.8° (<i>p</i> &lt; 0.05), and the mean score for the Oxford Ankle Foot Questionnaire for Children improved from 42 to 47 (<i>p</i> &lt; 0.05) after surgery. The mean score for the Questionnaire for Foot Macrodactyly was 9.35 at the time of follow-up. The goal of the treatment of pedal macrodactyly is to obtain a functional and cosmetically acceptable foot. This treatment algorithm and multi-technique procedure could fully satisfy this goal.
DOI: 10.6084/m9.figshare.18093256.v1
title: Surgical treatment of macrodactyly of the foot in children

description: The purpose of the study was to produce an algorithm and surgical procedure for optimum treatment of pedal macrodactyly. Surgery was performed on 27 feet of 26 patients with a mean age of 33 months at the time of surgery (range: 7–108 months). A multi-technique procedure based on the involved elements of the foot (soft tissue, phalanx, or metatarsal, or a combination of these) was adopted. The intermetatarsal width ratio, phalanx spread angle, and metatarsal spread angle was used to evaluate the severity of the macrodactyly and the effect of treatment. The Oxford Ankle Foot Questionnaire for Children and the Questionnaire for Foot Macrodactyly were employed to evaluate the clinical results. Under the guidelines of the treatment algorithm, all patients were successfully operated on using the multi-technique procedure; the sizes of the affected feet decreased significantly. After a mean of 33 months (range: 18–42 months) follow-up, the intermetatarsal width ratio decreased from 1.13 to 0.93 (<i>p</i> &lt; 0.05), the phalanx spread angle decreased from 31.3° to 17.9° (<i>p</i> &lt; 0.05), the metatarsal spread angle decreased from 33.2° to 15.8° (<i>p</i> &lt; 0.05), and the mean score for the Oxford Ankle Foot Questionnaire for Children improved from 42 to 47 (<i>p</i> &lt; 0.05) after surgery. The mean score for the Questionnaire for Foot Macrodactyly was 9.35 at the time of follow-up. The goal of the treatment of pedal macrodactyly is to obtain a functional and cosmetically acceptable foot. This treatment algorithm and multi-technique procedure could fully satisfy this goal.
DOI: 10.6084/m9.figshare.12850379
title: Clinical characteristics and outcomes of traditional Chinese medicine-induced liver injury: a systematic review

description: Traditional Chinese medicine (TCM) is becoming increasingly popular and related adverse events are often ignored or underestimated. This systematic review aimed to evaluate the clinical characteristics and outcomes of TCM-induced liver injury (TCM-ILI) and to estimate the proportion of TCM-ILI in all drug-induced liver injuries (DILI). China National Knowledge Infrastructure, Wanfang, VIP, PubMed, and Embase databases were searched. Demographic, clinical, and survival data were extracted and pooled. Factors associated with worse outcomes were calculated. For the proportion meta-analyses, the data were pooled by using a random-effects model. Overall, 21,027 articles were retrieved, of which 625 were finally included. There was a predominance of female and older patients. The proportion of liver transplantation was 2.18% (7/321). The mortality was 4.67% (15/321). Male, higher aspartate aminotransferase and direct bilirubin, and lower albumin were significantly associated with an increased risk of death/liver transplantation in TCM-ILI patients. The proportion of TCM-ILI in all DILI was 25.71%. The proportion was gradually increased with year. Our work summarises current knowledge regarding clinical presentation, disease course, and prognosis of TCM-ILI. TCM can result in hepatotoxicity, even death or necessitate life-saving liver transplantation. Governmental regulation of TCM products should be strictly established.
DOI: 10.6084/m9.figshare.12850379.v1
title: Clinical characteristics and outcomes of traditional Chinese medicine-induced liver injury: a systematic review

description: Traditional Chinese medicine (TCM) is becoming increasingly popular and related adverse events are often ignored or underestimated. This systematic review aimed to evaluate the clinical characteristics and outcomes of TCM-induced liver injury (TCM-ILI) and to estimate the proportion of TCM-ILI in all drug-induced liver injuries (DILI). China National Knowledge Infrastructure, Wanfang, VIP, PubMed, and Embase databases were searched. Demographic, clinical, and survival data were extracted and pooled. Factors associated with worse outcomes were calculated. For the proportion meta-analyses, the data were pooled by using a random-effects model. Overall, 21,027 articles were retrieved, of which 625 were finally included. There was a predominance of female and older patients. The proportion of liver transplantation was 2.18% (7/321). The mortality was 4.67% (15/321). Male, higher aspartate aminotransferase and direct bilirubin, and lower albumin were significantly associated with an increased risk of death/liver transplantation in TCM-ILI patients. The proportion of TCM-ILI in all DILI was 25.71%. The proportion was gradually increased with year. Our work summarises current knowledge regarding clinical presentation, disease course, and prognosis of TCM-ILI. TCM can result in hepatotoxicity, even death or necessitate life-saving liver transplantation. Governmental regulation of TCM products should be strictly established.
DOI: 10.6084/m9.figshare.18093164.v1
title: Additional file 4 of Iodine-125 seed represses the growth and facilitates the apoptosis of colorectal cancer cells by suppressing the methylation of miR-615 promoter

description: Additional file 4..
DOI: 10.6084/m9.figshare.12326129
title: Table 1

description: Table 1.
 Elemental and isotopic compositions of rock samples from the Mussoorie
 section, northern Indian Craton.
DOI: 10.6084/m9.figshare.12326141
title: Table B1

description: Table B1. Hg isotopic compositions of procedural and analytical standards and duplicates
DOI: 10.6084/m9.figshare.8131874
title: Meta-analysis of vitamin D supplementation in the treatment of chronic heart failure

description: <i>Objectives</i>. We performed a meta-analysis to determine whether vitamin D supplementation is beneficial in patients with chronic heart failure (CHF). <i>Design</i>. Meta-analysis of randomised controlled trials. <i>Results</i>. Vitamin D supplementation in patients with CHF improved health-related quality of life and C-reactive protein levels [weighted mean difference (WMD): 6.75, 95% confidence interval (CI): 2.87 to 10.64, <i>p</i> &lt; .001; standardised mean difference (SMD): −0.41, 95% CI: −0.71 to −0.11, <i>p</i> = .007]. However, this supplementation was not superior to conventional treatment in terms of mortality, changes in left ventricular ejection fraction (ΔLVEF), N-terminal pro-B-type natriuretic peptide or B-type natriuretic peptide levels, and 6-minute walk distance (risk ratio: 1.11, 95% CI: 0.79 to 1.57, <i>p</i> = .53; WMD: 2.56, 95% CI: −2.18 to 7.31, <i>p</i> = .29; SMD: −0.18, 95% CI: −0.42 to 0.06, <i>p</i> = .15; WMD: −23.30, 95% CI: −58.31 to 11.72, <i>p</i> = .19). In contrast, ΔLVEF significantly improved (WMD: 6.75, 95% CI: 4.16 to 9.34, <i>p</i> &lt; .001) in the subgroup without calcium supplementation. Additionally, some randomised controlled trials showed that adverse events were more frequent in people with high vitamin D levels. <i>Conclusions</i>. Vitamin D supplementation decreases serum levels of inflammatory markers and improves quality of life in CHF patients. Pooled analysis of vitamin D supplementation did not show reduced mortality or improved left ventricular function perhaps because of excessive increase in plasma 25-hydroxyvitamin D and calcium levels. Future studies should pay attention to vitamin D and calcium levels achieved.
DOI: 10.6084/m9.figshare.8131874.v1
title: Meta-analysis of vitamin D supplementation in the treatment of chronic heart failure

description: <i>Objectives</i>. We performed a meta-analysis to determine whether vitamin D supplementation is beneficial in patients with chronic heart failure (CHF). <i>Design</i>. Meta-analysis of randomised controlled trials. <i>Results</i>. Vitamin D supplementation in patients with CHF improved health-related quality of life and C-reactive protein levels [weighted mean difference (WMD): 6.75, 95% confidence interval (CI): 2.87 to 10.64, <i>p</i> &lt; .001; standardised mean difference (SMD): −0.41, 95% CI: −0.71 to −0.11, <i>p</i> = .007]. However, this supplementation was not superior to conventional treatment in terms of mortality, changes in left ventricular ejection fraction (ΔLVEF), N-terminal pro-B-type natriuretic peptide or B-type natriuretic peptide levels, and 6-minute walk distance (risk ratio: 1.11, 95% CI: 0.79 to 1.57, <i>p</i> = .53; WMD: 2.56, 95% CI: −2.18 to 7.31, <i>p</i> = .29; SMD: −0.18, 95% CI: −0.42 to 0.06, <i>p</i> = .15; WMD: −23.30, 95% CI: −58.31 to 11.72, <i>p</i> = .19). In contrast, ΔLVEF significantly improved (WMD: 6.75, 95% CI: 4.16 to 9.34, <i>p</i> &lt; .001) in the subgroup without calcium supplementation. Additionally, some randomised controlled trials showed that adverse events were more frequent in people with high vitamin D levels. <i>Conclusions</i>. Vitamin D supplementation decreases serum levels of inflammatory markers and improves quality of life in CHF patients. Pooled analysis of vitamin D supplementation did not show reduced mortality or improved left ventricular function perhaps because of excessive increase in plasma 25-hydroxyvitamin D and calcium levels. Future studies should pay attention to vitamin D and calcium levels achieved.
DOI: 10.48331/scielodata.82aec8/dngcsb
title: dungbeetles_pasturelands_data_maldaner.csv

description: Raw data
DOI: 10.48331/scielodata.82aec8/su2q8j
title: README.txt

description: Read me
DOI: 10.6084/m9.figshare.12850478
title: The safety and efficacy of endoscopic ultrasound-guided ablation therapy for solid pancreatic tumors: a systematic review

description: Recently, endoscopic ultrasound (EUS)-guided ablation therapy, as a minimally invasive technique, has shown its potential to substitute surgery in treating solid pancreatic tumors, such as small potential malignant pancreatic tumors, small insulinomas and locally advanced pancreatic ductal adenocarcinoma (LAPDAC). Therefore, we conducted this systematic review to assess the safety and efficacy of EUS-guided ablation therapy for solid pancreatic tumors. We conducted a comprehensive search of PubMed, Embase, Cochrane library and Web of Science databases from inception to February 2020. The endpoints were clinical success and complications rates. The pooled event rate was calculated using Comprehensive Meta Analysis software. Fourteen studies with a total of 158 patients were included in our final analysis. The major types of solid pancreatic tumors were nonfunction pancreatic neuroendocrine tumors (<i>n</i> = 78, 49.4%), LAPDAC (<i>n</i> = 48, 30.4%) and insulinomas (<i>n</i> = 26, 16.5%). Overall, the pooled clinical success rate was 85.9% (95% confidence interval (CI): 75.4–92.4%, <i>I</i><sup>2</sup> = 25.18%), pooled complications rate was 29.1% (95% CI: 18.6–42.3%, <i>I</i><sup>2</sup> = 50.40%). Subgroup analysis was performed based on ablation methods, which showed clinical success rate for radiofrequency ablation (RFA) was 83.5% (95% CI: 67.9–92.4%), and 87.9% (95% CI: 66.2–96.4%) for ethanol ablation (EA). In terms of complications rate, it was 32.2% (95% CI: 19.4–48.4%) for RFA, and 21.2% (95% CI: 6.8–49.9%) for EA. EUS-guided ablation therapy is a promising alternative treatment for solid pancreatic tumors, especially for p-NETs and insulinomas &lt; 2 cm, with rarely severe complications. Further prospective studies with long-term follow-up are warranted in future.
DOI: 10.6084/m9.figshare.12850478.v1
title: The safety and efficacy of endoscopic ultrasound-guided ablation therapy for solid pancreatic tumors: a systematic review

description: Recently, endoscopic ultrasound (EUS)-guided ablation therapy, as a minimally invasive technique, has shown its potential to substitute surgery in treating solid pancreatic tumors, such as small potential malignant pancreatic tumors, small insulinomas and locally advanced pancreatic ductal adenocarcinoma (LAPDAC). Therefore, we conducted this systematic review to assess the safety and efficacy of EUS-guided ablation therapy for solid pancreatic tumors. We conducted a comprehensive search of PubMed, Embase, Cochrane library and Web of Science databases from inception to February 2020. The endpoints were clinical success and complications rates. The pooled event rate was calculated using Comprehensive Meta Analysis software. Fourteen studies with a total of 158 patients were included in our final analysis. The major types of solid pancreatic tumors were nonfunction pancreatic neuroendocrine tumors (<i>n</i> = 78, 49.4%), LAPDAC (<i>n</i> = 48, 30.4%) and insulinomas (<i>n</i> = 26, 16.5%). Overall, the pooled clinical success rate was 85.9% (95% confidence interval (CI): 75.4–92.4%, <i>I</i><sup>2</sup> = 25.18%), pooled complications rate was 29.1% (95% CI: 18.6–42.3%, <i>I</i><sup>2</sup> = 50.40%). Subgroup analysis was performed based on ablation methods, which showed clinical success rate for radiofrequency ablation (RFA) was 83.5% (95% CI: 67.9–92.4%), and 87.9% (95% CI: 66.2–96.4%) for ethanol ablation (EA). In terms of complications rate, it was 32.2% (95% CI: 19.4–48.4%) for RFA, and 21.2% (95% CI: 6.8–49.9%) for EA. EUS-guided ablation therapy is a promising alternative treatment for solid pancreatic tumors, especially for p-NETs and insulinomas &lt; 2 cm, with rarely severe complications. Further prospective studies with long-term follow-up are warranted in future.
DOI: 10.48331/scielodata.82aec8/ilrkue
title: dungbeetles_pasturelands_data_maldaner-1.csv

description: :unav
DOI: 10.48331/scielodata.82aec8
title: Data for: Dung beetles in South American pasturelands / Besouros rola-bostas em pastagens sul-americanas

description: Geographical data for dung beetles in South American pasturelands
DOI: 10.6084/m9.figshare.12326321
title: Associations between depressive symptom profiles and immunometabolic characteristics in individuals with depression and their siblings

description: The present study examined associations between immunometabolic characteristics (IMCs) and depressive symptom profiles (DSPs) in probands with lifetime diagnoses of depression and/or anxiety disorders and their siblings. Data were from the Netherlands Study of Depression and Anxiety, comprising 256 probands with lifetime diagnoses of depression and/or anxiety and their 380 siblings. Measured IMCs included blood pressure, waist circumference, and levels of glucose, triglycerides, HDL cholesterol, CRP, TNF-α and IL-6. DSPs included mood, cognitive, somatic and atypical-like profiles. We cross-sectionally examined whether DSPs were associated with IMCs within probands and within siblings, and whether DSPs were associated with IMCs between probands and siblings. Within probands and within siblings, higher BMI and waist circumference were associated with higher somatic and atypical-like profiles. Other IMCs (IL-6, glucose and HDL cholesterol) were significantly related to DSPs either within probands or within siblings. DSPs and IMCs were not associated between probands and siblings. The results suggest that there is a familial component for each trait, but no common familial factors for the association between DSPs and IMCs. Alternative mechanisms, such as direct causal effects or non-shared environmental risk factors, may better fit these results.
DOI: 10.6084/m9.figshare.12326321.v1
title: Associations between depressive symptom profiles and immunometabolic characteristics in individuals with depression and their siblings

description: The present study examined associations between immunometabolic characteristics (IMCs) and depressive symptom profiles (DSPs) in probands with lifetime diagnoses of depression and/or anxiety disorders and their siblings. Data were from the Netherlands Study of Depression and Anxiety, comprising 256 probands with lifetime diagnoses of depression and/or anxiety and their 380 siblings. Measured IMCs included blood pressure, waist circumference, and levels of glucose, triglycerides, HDL cholesterol, CRP, TNF-α and IL-6. DSPs included mood, cognitive, somatic and atypical-like profiles. We cross-sectionally examined whether DSPs were associated with IMCs within probands and within siblings, and whether DSPs were associated with IMCs between probands and siblings. Within probands and within siblings, higher BMI and waist circumference were associated with higher somatic and atypical-like profiles. Other IMCs (IL-6, glucose and HDL cholesterol) were significantly related to DSPs either within probands or within siblings. DSPs and IMCs were not associated between probands and siblings. The results suggest that there is a familial component for each trait, but no common familial factors for the association between DSPs and IMCs. Alternative mechanisms, such as direct causal effects or non-shared environmental risk factors, may better fit these results.
DOI: 10.6084/m9.figshare.12850730
title: Measuring maternal body composition by biomedical impedance can predict risk for gestational diabetes mellitus: a retrospective study among 22,223 women

description: This study aimed to identify which element of body composition measurements taken before 17th week gestation was the strongest risk factor for gestational diabetes mellitus (GDM) in Chinese pregnant women. A retrospective study was performed using data retrieved from the Electronic Medical Record database of Chongqing Health Center for Women and Children (China) from January 2014 to December 2015. A total of 22,223 women were included with singleton pregnancies and no preexisting diabetes who underwent bioelectrical impedance analysis (BIA) before 17 gestational weeks and 75-g OGTT at 24–28 gestational weeks. The prevalence of GDM from 2014 to 2015 was 27.13% (IADPSG). All indicators of BIA (total body water, fat mass, fat-free mass, percent body fat, muscle mass, visceral fat levels, proteins, bone minerals, basal metabolic rate, lean trunk mass), age, weight and body mass index (BMI) were risk factors that significantly increased the occurrence of GDM (<i>p</i> &lt; .001 for all). Women older than 30 years or with a BMI more than 23, had a significantly higher GDM prevalence (34.89% and 34.77%). After adjusted covariates, visceral fat levels at the third quartile, the <i>ORs</i> of GDM were 1.142 (95% <i>CI</i> 1.032–1.263) in model I and 1.419 (95% <i>CI</i> 1.274–1.581) in model II used the first quartile as reference (<i>p</i> &lt; .05 for both); bone minerals at the third quartile, the <i>ORs</i> of GDM were 1.124 (95% <i>CI</i> 1.020–1.238) in model I and 1.311 (95% <i>CI</i> 1.192–1.442) in model II (<i>p</i> &lt; .05 for both). After adjusted for age, visceral fat levels and bone minerals, <i>OR</i> of GDM for percent body fat more than 28.77% at the third quartile was 1.334 (95% <i>CI</i> 1.201–1.482) in model II (<i>p</i> &lt; .05 for both). Visceral fat levels, bone minerals and percent body fat were significantly associated with an increased risk of GDM, providing the reference ranges of visceral fat levels, bone minerals and percent body fat as predictive factors for Chinese women to estimate the risk of GDM by BIA during pregnancy.