cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.3118525.v2
title: Epigenetic regulation by BAF (mSWI/SNF) chromatin remodeling complexes is indispensable for embryonic development

description: The multi-subunit chromatin-remodeling SWI/SNF (known as BAF for Brg/Brm-associated factor) complexes play essential roles in development. Studies have shown that the loss of individual BAF subunits often affects local chromatin structure and specific transcriptional programs. However, we do not fully understand how BAF complexes function in development because no animal mutant had been engineered to lack entire multi-subunit BAF complexes. Importantly, we recently reported that double conditional knock-out (<i>dcKO</i>) of the BAF155 and BAF170 core subunits in mice abolished the presence of the other BAF subunits in the developing cortex. The generated <i>dcKO</i> mutant provides a novel and powerful tool for investigating how entire BAF complexes affect cortical development. Using this model, we found that BAF complexes globally control the key heterochromatin marks, H3K27me2 and -3, by directly modulating the enzymatic activity of the H3K27 demethylases, Utx and Jmjd3. Here, we present further insights into how the scaffolding ability of the BAF155 and BAF170 core subunits maintains the stability of BAF complexes in the forebrain and throughout the embryo during development. Furthermore, we show that the loss of BAF complexes in the above-described model up-regulates H3K27me3 and impairs forebrain development and embryogenesis. These findings improve our understanding of epigenetic mechanisms and their modulation by the chromatin-remodeling SWI/SNF complexes that control embryonic development.
DOI: 10.6084/m9.figshare.3159703
title: mTOR transcriptionally and post-transcriptionally regulates Npm1 gene expression to contribute to enhanced proliferation in cells with Pten inactivation

description: The mammalian target of rapamycin (mTOR) plays essential roles in the regulation of growth-related processes such as protein synthesis, cell sizing and metabolism in both normal and pathological growing conditions. These functions of mTOR are thought to be largely a consequence of its cytoplasmic activity in regulating translation rate, but accumulating data highlight supplementary role(s) for this serine/threonine kinase within the nucleus. Indeed, the nuclear activities of mTOR are currently associated with the control of protein biosynthetic capacity through its ability to regulate the expression of gene products involved in the control of ribosomal biogenesis and proliferation. Using primary murine embryo fibroblasts (MEFs), we observed that cells with overactive mTOR signaling displayed higher abundance for the growth-associated Npm1 protein, in what represents a novel mechanism of Npm1 gene regulation. We show that Npm1 gene expression is dependent on mTOR as demonstrated by treatment of wild-type and Pten inactivated MEFs cultured with rapamycin or by transient transfections of small interfering RNA directed against mTOR. In accordance, the mTOR kinase localizes to the <i>Npm1</i> promoter gene <i>in vivo</i> and it enhances the activity of a human <i>NPM1</i>-luciferase reporter gene providing an opportunity for direct control. Interestingly, rapamycin did not dislodge mTOR from the <i>Npm1</i> promoter but rather strongly destabilized the <i>Npm1</i> transcript by increasing its turnover. Using a prostate-specific <i>Pten</i>-deleted mouse model of cancer, <i>Npm1</i> mRNA levels were found up-regulated and sensitive to rapamycin. Finally, we also showed that Npm1 is required to promote mTOR-dependent cell proliferation. We therefore proposed a model whereby mTOR is closely involved in the transcriptional and posttranscriptional regulation of Npm1 gene expression with implications in development and diseases including cancer.
DOI: 10.6084/m9.figshare.3159703.v2
title: mTOR transcriptionally and post-transcriptionally regulates Npm1 gene expression to contribute to enhanced proliferation in cells with Pten inactivation

description: The mammalian target of rapamycin (mTOR) plays essential roles in the regulation of growth-related processes such as protein synthesis, cell sizing and metabolism in both normal and pathological growing conditions. These functions of mTOR are thought to be largely a consequence of its cytoplasmic activity in regulating translation rate, but accumulating data highlight supplementary role(s) for this serine/threonine kinase within the nucleus. Indeed, the nuclear activities of mTOR are currently associated with the control of protein biosynthetic capacity through its ability to regulate the expression of gene products involved in the control of ribosomal biogenesis and proliferation. Using primary murine embryo fibroblasts (MEFs), we observed that cells with overactive mTOR signaling displayed higher abundance for the growth-associated Npm1 protein, in what represents a novel mechanism of Npm1 gene regulation. We show that Npm1 gene expression is dependent on mTOR as demonstrated by treatment of wild-type and Pten inactivated MEFs cultured with rapamycin or by transient transfections of small interfering RNA directed against mTOR. In accordance, the mTOR kinase localizes to the <i>Npm1</i> promoter gene <i>in vivo</i> and it enhances the activity of a human <i>NPM1</i>-luciferase reporter gene providing an opportunity for direct control. Interestingly, rapamycin did not dislodge mTOR from the <i>Npm1</i> promoter but rather strongly destabilized the <i>Npm1</i> transcript by increasing its turnover. Using a prostate-specific <i>Pten</i>-deleted mouse model of cancer, <i>Npm1</i> mRNA levels were found up-regulated and sensitive to rapamycin. Finally, we also showed that Npm1 is required to promote mTOR-dependent cell proliferation. We therefore proposed a model whereby mTOR is closely involved in the transcriptional and posttranscriptional regulation of Npm1 gene expression with implications in development and diseases including cancer.
DOI: 10.3535/64k-dlt-j99
title: Agrostis mertensii Trin.

description: Digital Specimen for the physical specimen hosted at Natural History Museum Vienna.
DOI: 10.3535/b2y-yq6-rkv
title: Agrostis castellana Boiss. & Reut.

description: Digital Specimen for the physical specimen hosted at Natural History Museum Vienna.
DOI: 10.3535/lmh-s2q-ge0
title: Phleum pratense L.

description: Digital Specimen for the physical specimen hosted at Natural History Museum Vienna.
DOI: 10.5517/ccnsh30
title: CCDC 619352: Experimental Crystal Structure Determination

description: Related Article: M.Baya, J.Houghton, J.-C.Daran, R.Poli|2007|Angew.Chem.,Int.Ed.|46|429|doi:10.1002/anie.200603628
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccnv92v
title: CCDC 621087: Experimental Crystal Structure Determination

description: Related Article: J.S.Clark, S.T.Hayes, C.Wilson, L.Gobbi|2007|Angew.Chem.,Int.Ed.|46|437|doi:10.1002/anie.200603880
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.6084/m9.figshare.3118525.v1
title: Epigenetic regulation by BAF (mSWI/SNF) chromatin remodeling complexes is indispensable for embryonic development

description: The multi-subunit chromatin-remodeling SWI/SNF (known as BAF for Brg/Brm-associated factor) complexes play essential roles in development. Studies have shown that the loss of individual BAF subunits often affects local chromatin structure and specific transcriptional programs. However, we do not fully understand how BAF complexes function in development because no animal mutant had been engineered to lack entire multi-subunit BAF complexes. Importantly, we recently reported that double conditional knock-out (<i>dcKO</i>) of the BAF155 and BAF170 core subunits in mice abolished the presence of the other BAF subunits in the developing cortex. The generated <i>dcKO</i> mutant provides a novel and powerful tool for investigating how entire BAF complexes affect cortical development. Using this model, we found that BAF complexes globally control the key heterochromatin marks, H3K27me2 and -3, by directly modulating the enzymatic activity of the H3K27 demethylases, Utx and Jmjd3. Here, we present further insights into how the scaffolding ability of the BAF155 and BAF170 core subunits maintains the stability of BAF complexes in the forebrain and throughout the embryo during development. Furthermore, we show that the loss of BAF complexes in the above-described model up-regulates H3K27me3 and impairs forebrain development and embryogenesis. These findings improve our understanding of epigenetic mechanisms and their modulation by the chromatin-remodeling SWI/SNF complexes that control embryonic development.
DOI: 10.6084/m9.figshare.3159703.v1
title: mTOR transcriptionally and post-transcriptionally regulates <i>Npm1</i> gene expression to contribute to enhanced proliferation in cells with <i>Pten</i> inactivation

description: The mammalian target of rapamycin (mTOR) plays essential roles in the regulation of growth-related processes such as protein synthesis, cell sizing and metabolism in both normal and pathological growing conditions. These functions of mTOR are thought to be largely a consequence of its cytoplasmic activity in regulating translation rate, but accumulating data highlight supplementary role(s) for this serine/threonine kinase within the nucleus. Indeed, the nuclear activities of mTOR are currently associated with the control of protein biosynthetic capacity through its ability to regulate the expression of gene products involved in the control of ribosomal biogenesis and proliferation. Using primary murine embryo fibroblasts (MEFs), we observed that cells with overactive mTOR signaling displayed higher abundance for the growth-associated Npm1 protein, in what represents a novel mechanism of <i>Npm1</i> gene regulation. We show that <i>Npm1</i> gene expression is dependent on mTOR as demonstrated by treatment of wild-type and Pten inactivated MEFs cultured with rapamycin or by transient transfections of small interfering RNA directed against mTOR. In accordance, the mTOR kinase localizes to the <i>Npm1</i> promoter gene <i>in vivo</i> and it enhances the activity of a human <i>NPM1</i>-luciferase reporter gene providing an opportunity for direct control. Interestingly, rapamycin did not dislodge mTOR from the <i>Npm1</i> promoter but rather strongly destabilized the <i>Npm1</i> transcript by increasing its turnover. Using a prostate-specific <i>Pten</i>-deleted mouse model of cancer, <i>Npm1</i> mRNA levels were found up-regulated and sensitive to rapamycin. Finally, we also showed that Npm1 is required to promote mTOR-dependent cell proliferation. We therefore proposed a model whereby mTOR is closely involved in the transcriptional and posttranscriptional regulation of <i>Npm1</i> gene expression with implications in development and diseases including cancer.
DOI: 10.13140/rg.2.2.36257.92002
title: International Conference on the Advancement of Green Energy Technology: Shaping Our Future with Green Energy
DOI: 10.3535/flg-4ht-g2h
title: Launaea arborescens (Batt.) Murb.

description: Digital Specimen for the physical specimen hosted at Natural History Museum Vienna.
DOI: 10.3535/vmq-6mr-gnp
title: Cousinia fragilis C. Winkl. & Bornm.

description: Digital Specimen for the physical specimen hosted at Natural History Museum Vienna.
DOI: 10.5281/zenodo.17370281
title: 4-the-echo-protocol-korean
DOI: 10.5517/ccnsh41
title: CCDC 619353: Experimental Crystal Structure Determination

description: Related Article: M.Baya, J.Houghton, J.-C.Daran, R.Poli|2007|Angew.Chem.,Int.Ed.|46|429|doi:10.1002/anie.200603628
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.3535/qy8-982-l61
title: Phleum pratense L.

description: Digital Specimen for the physical specimen hosted at Natural History Museum Vienna.
DOI: 10.3535/rd7-sbj-jzf
title: Hieracium bifidum Kit. ex Hornem.

description: Digital Specimen for the physical specimen hosted at Natural History Museum Vienna.
DOI: 10.3535/zsr-feg-bg6
title: Agrostis stolonifera L.

description: Digital Specimen for the physical specimen hosted at Natural History Museum Vienna.
DOI: 10.5517/ccnrrsx
title: CCDC 618660: Experimental Crystal Structure Determination

description: Related Article: D.Enders, M.R.M.Huttl, G.Raabe, J.W.Bats|2008|Adv.Synth.Catal.|350|267|doi:10.1002/adsc.200700396
description: Related Article: D.Enders, M.R.M.Huttl, J.Runsink, G.Raabe, B.Wendt|2007|Angew.Chem.,Int.Ed.|46|467|doi:10.1002/anie.200603434
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccnsh52
title: CCDC 619354: Experimental Crystal Structure Determination

description: Related Article: M.Baya, J.Houghton, J.-C.Daran, R.Poli|2007|Angew.Chem.,Int.Ed.|46|429|doi:10.1002/anie.200603628
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.13140/rg.2.2.36362.77769
title: O’Shea, R. P. (2017). On “stereoscopy” and “stereopsis” [Blog post]. Retrieved from https://robertposhea.blogspot.com/2017/08/origins-of-stereoscopy-and-stereopsis.html
DOI: 10.3535/78a-c7b-zb6
title: Declieuxia fruticosa (Willd. ex Roem. & Schult.) Kuntze

description: Digital Specimen for the physical specimen hosted at Natural History Museum Vienna.
DOI: 10.3535/gxz-al1-wn2
title: Hieracium lachenalii C. C. Gmel.

description: Digital Specimen for the physical specimen hosted at Natural History Museum Vienna.
DOI: 10.3535/xsw-ab1-rwb
title: Laserpitium winkleri Herbich

description: Digital Specimen for the physical specimen hosted at Natural History Museum Vienna.
DOI: 10.5517/ccnq4wc
title: CCDC 617113: Experimental Crystal Structure Determination

description: Related Article: G.Givaja, M.Volpe, M.A.Edwards, A.J.Blake, C.Wilson, M.Schroder, J.B.Love|2007|Angew.Chem.,Int.Ed.|46|584|doi:10.1002/anie.200603201
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccnq4xd
title: CCDC 617114: Experimental Crystal Structure Determination

description: Related Article: G.Givaja, M.Volpe, M.A.Edwards, A.J.Blake, C.Wilson, M.Schroder, J.B.Love|2007|Angew.Chem.,Int.Ed.|46|584|doi:10.1002/anie.200603201
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.13140/rg.2.2.16387.40485
title: Eschbach et al. - 2013 - Poster IAG
DOI: 10.3535/657-4zc-dvg
title: Rudgea corymbulosa Benth.

description: Digital Specimen for the physical specimen hosted at Natural History Museum Vienna.
DOI: 10.3535/9yq-ac5-4zn
title: Calamagrostis epigejos (L.) Roth

description: Digital Specimen for the physical specimen hosted at Natural History Museum Vienna.
DOI: 10.5517/ccnr1m1
title: CCDC 617973: Experimental Crystal Structure Determination

description: Related Article: W.W.Brennessel, J.E.Ellis|2007|Angew.Chem.,Int.Ed.|46|598|doi:10.1002/anie.200603746
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccnr1n2
title: CCDC 617974: Experimental Crystal Structure Determination

description: Related Article: W.W.Brennessel, J.E.Ellis|2007|Angew.Chem.,Int.Ed.|46|598|doi:10.1002/anie.200603746
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.3535/0ev-l2d-yzd
title: Festuca amethystina L.

description: Digital Specimen for the physical specimen hosted at Natural History Museum Vienna.
DOI: 10.3535/e4m-1fy-r87
title: Blakea monticola J. R. Johnst.

description: Digital Specimen for the physical specimen hosted at Natural History Museum Vienna.
DOI: 10.3535/q58-yzc-5sv
title: Calamagrostis epigejos (L.) Roth

description: Digital Specimen for the physical specimen hosted at Natural History Museum Vienna.
DOI: 10.5517/ccnr1p3
title: CCDC 617975: Experimental Crystal Structure Determination

description: Related Article: W.W.Brennessel, J.E.Ellis|2007|Angew.Chem.,Int.Ed.|46|598|doi:10.1002/anie.200603746
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.3535/3by-dm7-9qy
title: Manettia congesta (Vell.) K. Schum.

description: Digital Specimen for the physical specimen hosted at Natural History Museum Vienna.
DOI: 10.3535/amc-vcy-cx2
title: Eremopyrum distans (K. Koch) Nevski

description: Digital Specimen for the physical specimen hosted at Natural History Museum Vienna.
DOI: 10.5517/ccnr2wb
title: CCDC 618012: Experimental Crystal Structure Determination

description: Related Article: Roland Boese, Andrew D. Bond, Gautam R. Desiraju|2008|U.S.Patents|||
description: Related Article: A.D.Bond, R.Boese, G.R.Desiraju|2007|Angew.Chem.,Int.Ed.|46|618|doi:10.1002/anie.200603373
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.3535/ls0-g9c-qdk
title: Alliaria petiolata (M. Bieb.) Cavara & Grande

description: Digital Specimen for the physical specimen hosted at Natural History Museum Vienna.
DOI: 10.3535/vcd-vbq-zhb
title: Hieracium bifidum subsp. saxigenum (Wiesb. ex Dichtl) Zahn

description: Digital Specimen for the physical specimen hosted at Natural History Museum Vienna.
DOI: 10.5517/ccnr1r5
title: CCDC 617977: Experimental Crystal Structure Determination

description: Related Article: B.S.Lucas, V.Gopalsamuthiram, S.D.Burke|2007|Angew.Chem.,Int.Ed.|46|769|doi:10.1002/anie.200603656
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccnrv8h
title: CCDC 618737: Experimental Crystal Structure Determination

description: Related Article: I.Kieltsch, P.Eisenberger, A.Togni|2007|Angew.Chem.,Int.Ed.|46|754|doi:10.1002/anie.200603497
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.3535/76s-e0r-2ym
title: Festuca stenantha (Hack.) K. Richt. x Festuca sulcata (Hack.) Beck

description: Digital Specimen for the physical specimen hosted at Natural History Museum Vienna.
DOI: 10.3535/jqy-69l-h4n
title: Saxifraga rigoi Freyn & Porta

description: Digital Specimen for the physical specimen hosted at Natural History Museum Vienna.
DOI: 10.3535/ycv-l6l-b4k
title: Festuca magellanica Lam.

description: Digital Specimen for the physical specimen hosted at Natural History Museum Vienna.
DOI: 10.5517/cc8zxjn
title: CCDC 268042: Experimental Crystal Structure Determination

description: Related Article: Shengming Ma, Lianghua Lu|2007|Chem.Asian J.|2|199|doi:10.1002/asia.200600274
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.3535/fg1-zse-9r0
title: Alopecurus aequalis Sobol.

description: Digital Specimen for the physical specimen hosted at Natural History Museum Vienna.
DOI: 10.3535/fpr-s9t-dlm
title: Diodia radula (Willd. ex Roem. & Schult.) Cham. & Schltdl.

description: Digital Specimen for the physical specimen hosted at Natural History Museum Vienna.
DOI: 10.5517/cc8zxkp
title: CCDC 268043: Experimental Crystal Structure Determination

description: Related Article: Shengming Ma, Lianghua Lu|2007|Chem.Asian J.|2|199|doi:10.1002/asia.200600274
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/cc9mzwr
title: CCDC 287335: Experimental Crystal Structure Determination

description: Related Article: Shengming Ma, Lianghua Lu|2007|Chem.Asian J.|2|199|doi:10.1002/asia.200600274
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.