cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.6853949
title: Supplementary Material for: Failure to Respond after Reinstatement of Antidepressant Medication: A Systematic Review

description: <b><i>Background:</i></b> Following remission of an anxiety disorder or a depressive disorder, antidepressants are frequently discontinued and in the case of symptom occurrence reinstated. Reinstatement of antidepressants seems less effective in some patients, but an overview is lacking. This systematic review aimed to provide insight into the magnitude and risk factors of response failure after reinstatement of antidepressants in patients with anxiety disorders, depressive disorders, obsessive-compulsive disorder (OCD), or posttraumatic stress disorder (PTSD). <b><i>Method:</i></b> PubMed, Embase, and trial registers were systematically searched for studies in which patients: (1) had an anxiety disorder, a depressive disorder, OCD, or PTSD and (2) experienced failure to respond after reinstatement of a previously effective antidepressant. <b><i>Results:</i></b> Ten studies reported failure to respond following antidepressant reinstatement. The phenomenon was observed in 16.5% of patients with a depressive disorder, OCD, and social phobia and occurred in all common classes of antidepressants. The range of response failure was broad, varying between 3.8 and 42.9% across studies. No risk factors for failure to respond were investigated. The overall study quality was limited. <b><i>Conclusion:</i></b> Research investigating response failure is scarce and the study quality limited. Response failure occurred in a substantial minority of patients. Contributors to the relevance of this phenomenon are the prevalence of the investigated disorders, the number of patients being treated with antidepressants, and the occurrence of response failure for all common classes of antidepressants. This systematic review highlights the need for studies systematically investigating this phenomenon and associated risk factors.
DOI: 10.6084/m9.figshare.6853961.v1
title: Comparative analysis of B-cell receptor repertoires induced by live yellow fever vaccine in young and middle age donors

description: Immunoglobulin repertoires from healthy volunteers of two age groups (young and middle age). Plasma B cells were obtained from peripheral blood samples at 9th day after first vaccination with live YF vaccine.
DOI: 10.6084/m9.figshare.6853961.v2
title: Comparative analysis of B-cell receptor repertoires induced by live yellow fever vaccine in young and middle age donors

description: Immunoglobulin repertoires (top-1569 clonotypes) from healthy volunteers of two age groups, young and middle age. Plasma B cells were obtained from peripheral blood samples at 9th day after first vaccination with live YF vaccine.
DOI: 10.6084/m9.figshare.6853931
title: A database of annual atmospheric acid and nutrient deposition to China’s forests

description: Based on a comprehensive literature review, here I present an updated database for annual acid and nutrient deposition in China’s forests (CFAND 2.0). It includes information from 56 forested sites on the water fluxes of bulk precipitation and throughfall, the concentrations of H<sup>+ </sup>(pH), dissolved inorganic N (NH<sub>4</sub><sup>+</sup>-N and NO<sub>3</sub><sup>-</sup>-N), S, dissolved P, K<sup>+</sup>, Ca<sup>2+</sup> and Mg<sup>2+</sup> in bulk precipitation and throughfall, and the fluxes of dissolved inorganic N, S, dissolved P, K<sup>+</sup>, Ca<sup>2+</sup> and Mg<sup>2+</sup> in bulk deposition and throughfall, as well as geographical information and forest type.
DOI: 10.6084/m9.figshare.6853931.v1
title: A database for atmospheric acid and nutrient deposition in China’s forests

description: Based on a comprehensive literature review, here I present an updated database for acid and nutrient deposition in China’s forests (CFAND 2.0). It includes detailed information from 56 forested sites on water fluxes of bulk precipitation and throughfall, concentrations of H<sup>+ </sup>(pH), dissolved inorganic N (as a sum of NH<sub>4</sub><sup>+</sup>-N and NO<sub>3</sub><sup>-</sup>-N), S, dissolved P, K<sup>+</sup>, Ca<sup>2+</sup> and Mg<sup>2+</sup> in bulk precipitation and throughfall, and fluxes of dissolved inorganic N, S, dissolved P, K<sup>+</sup>, Ca<sup>2+</sup> and Mg<sup>2+</sup> in bulk deposition and throughfall, as well as geographical information and forest type.
DOI: 10.6084/m9.figshare.6853931.v2
title: A database for annual atmospheric acid and nutrient deposition in China’s forests

description: Based on a comprehensive literature review, here I present an updated database for acid and nutrient deposition in China’s forests (CFAND 2.0). It includes detailed information from 56 forested sites on water fluxes of bulk precipitation and throughfall, concentrations of H<sup>+ </sup>(pH), dissolved inorganic N (NH<sub>4</sub><sup>+</sup>-N and NO<sub>3</sub><sup>-</sup>-N), S, dissolved P, K<sup>+</sup>, Ca<sup>2+</sup> and Mg<sup>2+</sup> in bulk precipitation and throughfall, and fluxes of dissolved inorganic N, S, dissolved P, K<sup>+</sup>, Ca<sup>2+</sup> and Mg<sup>2+</sup> in bulk deposition and throughfall, as well as geographical information and forest type.
DOI: 10.6084/m9.figshare.6853922
title: Land suitability assessment of the Olomouc region: an application of an Urban Planner model

description: This paper and accompanying maps focus on a land suitability assessment of the Olomouc region in the Czech Republic. All results were calculated in Urban Planner, a model designed by the authors of this paper. The method of calculation is based on a multi-criteria analysis (weighted overlay method), respects the principles of sustainable development, and allows for execution of several scenarios. The main result of this work is a set of maps. The first map sheet shows the land suitability for housing, recreation, public services, heavy industry, light industry, and transportation. The second map sheet consists of four maps showing different scenarios of land suitability for housing: one map showing the evaluation of existing proposals for housing from urban plans, and one map showing optimal areas for housing calculated by the Urban Planner model. The maps can be used as a significant source of information about the suitability of development in the Olomouc region in geographic or urban studies, both for experts and the general public. All thematic maps are on the scale of 1:125,000; supplementary maps are smaller.
DOI: 10.6084/m9.figshare.6853931.v3
title: A database for annual atmospheric acid and nutrient deposition in China’s forests

description: Based on a comprehensive literature review, here I present an updated database for acid and nutrient deposition in China’s forests (CFAND 2.0). It includes detailed information from 56 forested sites on water fluxes of bulk precipitation and throughfall, concentrations of H<sup>+ </sup>(pH), dissolved inorganic N (NH<sub>4</sub><sup>+</sup>-N and NO<sub>3</sub><sup>-</sup>-N), S, dissolved P, K<sup>+</sup>, Ca<sup>2+</sup> and Mg<sup>2+</sup> in bulk precipitation and throughfall, and fluxes of dissolved inorganic N, S, dissolved P, K<sup>+</sup>, Ca<sup>2+</sup> and Mg<sup>2+</sup> in bulk deposition and throughfall, as well as geographical information and forest type.
DOI: 10.6084/m9.figshare.6853922.v1
title: Land suitability assessment of the Olomouc region: an application of an Urban Planner model

description: This paper and accompanying maps focus on a land suitability assessment of the Olomouc region in the Czech Republic. All results were calculated in Urban Planner, a model designed by the authors of this paper. The method of calculation is based on a multi-criteria analysis (weighted overlay method), respects the principles of sustainable development, and allows for execution of several scenarios. The main result of this work is a set of maps. The first map sheet shows the land suitability for housing, recreation, public services, heavy industry, light industry, and transportation. The second map sheet consists of four maps showing different scenarios of land suitability for housing: one map showing the evaluation of existing proposals for housing from urban plans, and one map showing optimal areas for housing calculated by the Urban Planner model. The maps can be used as a significant source of information about the suitability of development in the Olomouc region in geographic or urban studies, both for experts and the general public. All thematic maps are on the scale of 1:125,000; supplementary maps are smaller.
DOI: 10.6084/m9.figshare.6853931.v4
title: A database for annual atmospheric acid and nutrient deposition in China’s forests

description: Based on a comprehensive literature review, here I present an updated database for acid and nutrient deposition in China’s forests (CFAND 2.0). It includes detailed information from 56 forested sites on water fluxes of bulk precipitation and throughfall, concentrations of H<sup>+ </sup>(pH), dissolved inorganic N (NH<sub>4</sub><sup>+</sup>-N and NO<sub>3</sub><sup>-</sup>-N), S, dissolved P, K<sup>+</sup>, Ca<sup>2+</sup> and Mg<sup>2+</sup> in bulk precipitation and throughfall, and fluxes of dissolved inorganic N, S, dissolved P, K<sup>+</sup>, Ca<sup>2+</sup> and Mg<sup>2+</sup> in bulk deposition and throughfall, as well as geographical information and forest type.
DOI: 10.6084/m9.figshare.6853877
title: A binary QSAR model for classifying neuraminidase inhibitors of influenza A viruses (H1N1) using the combined minimum redundancy maximum relevancy criterion with the sparse support vector machine

description: Quantitative structure–activity relationship (QSAR) classification modelling with descriptor selection has become increasingly important because of the existence of large datasets in terms of either the number of compounds or the number of descriptors. Descriptor selection can improve the accuracy of QSAR classification studies and reduce their computation complexity by removing the irrelevant and redundant descriptors. In this paper, a two-stage classification approach is proposed by combining the minimum redundancy maximum relevancy criterion with the sparse support vector machine. The experimental results of classifying the neuraminidase inhibitors of influenza A (H1N1) viruses show that the proposed method is able to effectively outperform other sparse alternatives methods in terms of classification performance and the number of selected descriptors.
DOI: 10.6084/m9.figshare.6853877.v1
title: A binary QSAR model for classifying neuraminidase inhibitors of influenza A viruses (H1N1) using the combined minimum redundancy maximum relevancy criterion with the sparse support vector machine

description: Quantitative structure–activity relationship (QSAR) classification modelling with descriptor selection has become increasingly important because of the existence of large datasets in terms of either the number of compounds or the number of descriptors. Descriptor selection can improve the accuracy of QSAR classification studies and reduce their computation complexity by removing the irrelevant and redundant descriptors. In this paper, a two-stage classification approach is proposed by combining the minimum redundancy maximum relevancy criterion with the sparse support vector machine. The experimental results of classifying the neuraminidase inhibitors of influenza A (H1N1) viruses show that the proposed method is able to effectively outperform other sparse alternatives methods in terms of classification performance and the number of selected descriptors.
DOI: 10.6084/m9.figshare.6853799
title: Supplementary Material for: Management of Spontaneous Pneumothorax and Post-Interventional Pneumothorax: German S3 Guideline

description: In Germany, 10,000 cases of spontaneous pneumothorax are treated inpatient every year. The German Society for Thoracic Surgery, in co-operation with the German Society for Pulmonology, the German Radiological Society, and the German Society of Internal Medicine has developed an S3 guideline on spontaneous pneumothorax and post-interventional pneumothorax moderated by the German Association of Scientific Medical Societies. <b><i>Method:</i></b> Based on the source guideline of the British Thoracic Society (2010) for spontaneous pneumothorax, a literature search on spontaneous pneumothorax was carried out from 2008 onwards, for post-interventional pneumothorax from 1960 onwards. Evidence levels according to the Oxford Center for Evidence-Based Medicine (2011) were assigned to the relevant studies found. Recommendations according to grade (A: “we recommend”/“we do not recommend,” B: “we suggest”/“we do not suggest”) were determined in 3 consensus conferences by the nominal group process. <b><i>Results:</i></b> The algorithms for primary and secondary pneumothorax differ in the indication for CT scan as well as in the indication for chest drainage application and video-assisted thoracic surgery. Indication for surgery is recommended individually taking into account the risk of recurrence, life circumstances, patient preferences, and procedure risks. For some forms of secondary pneumothorax, a reserved indication for surgery is recommended. Therapy of post-interventional spontaneous pneumothorax is similar to that of primary spontaneous pneumothorax. <b><i>Discussion:</i></b> The recommendations of the S3 Guideline provide assistance in managing spontaneous pneumothorax and post-interventional pneumothorax. Whether this will affect existing deviant diagnostic and therapeutic measures will be demonstrated by future epidemiological studies.
DOI: 10.6084/m9.figshare.6853586
title: Homeobox transcription factors of straw mushroom Volvariella volvaceaG3/2018/200599 Identification and expression analysis of homeobox transcription factors in fruiting body development of straw mushroom Volvariella volvaceaHomeobox transcription factors of straw mushroom Volvariella volvacea

description: Supplementary Table 1 Distribution of transcription factor families in Volvariella volvaceaSupplementary Table 2 Gene expression profiles of 21 homeobox transcription factors in Volvariella volvacea<br><br>G3/2018/200599<br>
DOI: 10.6084/m9.figshare.6853586.v1
title: G3/2018/200599 Identification and expression analysis of homeobox transcription factors in fruiting body development of straw mushroom Volvariella volvacea

description: Supplementary Table 1 Distribution of transcription factor families in Volvariella volvaceaSupplementary Table 2 Gene expression profiles of 21 homeobox transcription factors in Volvariella volvacea<br><br>G3/2018/200599<br>
DOI: 10.6084/m9.figshare.6853406
title: Loss of p53 expression in cancer cells alters cell cycle response after inhibition of exportin-1 but does not prevent cell death

description: The tumor suppressor protein p53 is central to the cellular stress response and may be a predictive biomarker for cancer treatments. Upon stress, wildtype p53 accumulates in the nucleus where it enforces cellular responses, including cell cycle arrest and cell death. p53 is so dominant in its effects, that p53 enforcement – or – restoration therapy is being studied for anti-cancer therapy. Two mechanistically distinct small molecules that act via p53 are the selective inhibitor of nuclear export, selinexor, and MDM2 inhibitor, nutlin-3a. Here, individual cells are studied to define cell cycle response signatures, which captures the variability of responses and includes the impact of loss of p53 expression on cell fates. The individual responses are then used to build the population level response. Matched cell lines with and without p53 expression indicate that while loss-of-function results in altered cell cycle signatures to selinexor treatment, it does not diminish overall cell loss. On the contrary, response to single-agent nutlin-3a shows a strong p53-dependence. Upon treatment with both selinexor and nutlin-3a there are combination effects in at least some cell lines – even when p53 is absent. Collectively, the findings indicate that p53 does act downstream of selinexor and nutlin-3a, and that p53 expression is dispensable for selinexor to cause cell death, but nutlin-3a response is more p53-dependent. Thus, TP53 disruption and lack of expression may not predict poor cell response to selinexor, and selinexor’s mechanism of action potentially provides for strong efficacy regardless of p53 function.
DOI: 10.6084/m9.figshare.6853406.v1
title: Loss of p53 expression in cancer cells alters cell cycle response after inhibition of exportin-1 but does not prevent cell death

description: The tumor suppressor protein p53 is central to the cellular stress response and may be a predictive biomarker for cancer treatments. Upon stress, wildtype p53 accumulates in the nucleus where it enforces cellular responses, including cell cycle arrest and cell death. p53 is so dominant in its effects, that p53 enforcement – or – restoration therapy is being studied for anti-cancer therapy. Two mechanistically distinct small molecules that act via p53 are the selective inhibitor of nuclear export, selinexor, and MDM2 inhibitor, nutlin-3a. Here, individual cells are studied to define cell cycle response signatures, which captures the variability of responses and includes the impact of loss of p53 expression on cell fates. The individual responses are then used to build the population level response. Matched cell lines with and without p53 expression indicate that while loss-of-function results in altered cell cycle signatures to selinexor treatment, it does not diminish overall cell loss. On the contrary, response to single-agent nutlin-3a shows a strong p53-dependence. Upon treatment with both selinexor and nutlin-3a there are combination effects in at least some cell lines – even when p53 is absent. Collectively, the findings indicate that p53 does act downstream of selinexor and nutlin-3a, and that p53 expression is dispensable for selinexor to cause cell death, but nutlin-3a response is more p53-dependent. Thus, TP53 disruption and lack of expression may not predict poor cell response to selinexor, and selinexor’s mechanism of action potentially provides for strong efficacy regardless of p53 function.
DOI: 10.6084/m9.figshare.6853406.v2
title: Loss of p53 expression in cancer cells alters cell cycle response after inhibition of exportin-1 but does not prevent cell death

description: The tumor suppressor protein p53 is central to the cellular stress response and may be a predictive biomarker for cancer treatments. Upon stress, wildtype p53 accumulates in the nucleus where it enforces cellular responses, including cell cycle arrest and cell death. p53 is so dominant in its effects, that p53 enforcement – or – restoration therapy is being studied for anti-cancer therapy. Two mechanistically distinct small molecules that act via p53 are the selective inhibitor of nuclear export, selinexor, and MDM2 inhibitor, nutlin-3a. Here, individual cells are studied to define cell cycle response signatures, which captures the variability of responses and includes the impact of loss of p53 expression on cell fates. The individual responses are then used to build the population level response. Matched cell lines with and without p53 expression indicate that while loss-of-function results in altered cell cycle signatures to selinexor treatment, it does not diminish overall cell loss. On the contrary, response to single-agent nutlin-3a shows a strong p53-dependence. Upon treatment with both selinexor and nutlin-3a there are combination effects in at least some cell lines – even when p53 is absent. Collectively, the findings indicate that p53 does act downstream of selinexor and nutlin-3a, and that p53 expression is dispensable for selinexor to cause cell death, but nutlin-3a response is more p53-dependent. Thus, TP53 disruption and lack of expression may not predict poor cell response to selinexor, and selinexor’s mechanism of action potentially provides for strong efficacy regardless of p53 function.
DOI: 10.6084/m9.figshare.6853187
title: Additional file 9: of Longitudinal expression profiling of CD4+ and CD8+ cells in patients with active to quiescent giant cell arteritis

description: Table S6. Significant polynomial modelling results. (XLSX 62 kb)
DOI: 10.6084/m9.figshare.6853178
title: Additional file 8: of Longitudinal expression profiling of CD4+ and CD8+ cells in patients with active to quiescent giant cell arteritis

description: Table S5. Differential expression results CD8. (XLSX 1097 kb)
DOI: 10.6084/m9.figshare.6853178.v1
title: Additional file 8: of Longitudinal expression profiling of CD4+ and CD8+ cells in patients with active to quiescent giant cell arteritis

description: Table S5. Differential expression results CD8. (XLSX 1097 kb)
DOI: 10.6084/m9.figshare.6853166
title: Additional file 7: of Longitudinal expression profiling of CD4+ and CD8+ cells in patients with active to quiescent giant cell arteritis

description: Table S4. Differential expression results CD4. (XLSX 272 kb)
DOI: 10.6084/m9.figshare.6853166.v1
title: Additional file 7: of Longitudinal expression profiling of CD4+ and CD8+ cells in patients with active to quiescent giant cell arteritis

description: Table S4. Differential expression results CD4. (XLSX 272 kb)
DOI: 10.6084/m9.figshare.6853136
title: Additional file 7 of How does roadside vegetation management affect the diversity of vascular plants and invertebrates? A systematic review

description: Additional file 7. Weighted quantitative analysis.
DOI: 10.6084/m9.figshare.6853136.v1
title: MOESM7 of How does roadside vegetation management affect the diversity of vascular plants and invertebrates? A systematic review

description: Additional file 7. Weighted quantitative analysis.
DOI: 10.6084/m9.figshare.6853136.v2
title: Additional file 7 of How does roadside vegetation management affect the diversity of vascular plants and invertebrates? A systematic review

description: Additional file 7. Weighted quantitative analysis.
DOI: 10.6084/m9.figshare.6853124
title: Additional file 6 of How does roadside vegetation management affect the diversity of vascular plants and invertebrates? A systematic review

description: Additional file 6. Unweighted quantitative analysis.
DOI: 10.6084/m9.figshare.6853124.v2
title: Additional file 6 of How does roadside vegetation management affect the diversity of vascular plants and invertebrates? A systematic review

description: Additional file 6. Unweighted quantitative analysis.
DOI: 10.6084/m9.figshare.6853124.v1
title: MOESM6 of How does roadside vegetation management affect the diversity of vascular plants and invertebrates? A systematic review

description: Additional file 6. Unweighted quantitative analysis.
DOI: 10.6084/m9.figshare.6853106
title: Additional file 5 of How does roadside vegetation management affect the diversity of vascular plants and invertebrates? A systematic review

description: Additional file 5. Narrative table.
DOI: 10.6084/m9.figshare.6853106.v2
title: Additional file 5 of How does roadside vegetation management affect the diversity of vascular plants and invertebrates? A systematic review

description: Additional file 5. Narrative table.
DOI: 10.6084/m9.figshare.6853106.v1
title: MOESM5 of How does roadside vegetation management affect the diversity of vascular plants and invertebrates? A systematic review

description: Additional file 5. Narrative table.
DOI: 10.6084/m9.figshare.6853088
title: Additional file 4 of How does roadside vegetation management affect the diversity of vascular plants and invertebrates? A systematic review

description: Additional file 4. Extracted data records.
DOI: 10.6084/m9.figshare.6853088.v2
title: Additional file 4 of How does roadside vegetation management affect the diversity of vascular plants and invertebrates? A systematic review

description: Additional file 4. Extracted data records.
DOI: 10.6084/m9.figshare.6853088.v1
title: MOESM4 of How does roadside vegetation management affect the diversity of vascular plants and invertebrates? A systematic review

description: Additional file 4. Extracted data records.