DOI: 10.6084/m9.figshare.24921252.v3
title: Local origin of excitatory-inhibitory tuning equivalence in a cortical network (Duszkiewicz et al 2024)

description: Datasets and code from the manuscript:<br>Duszkiewicz et al, Nature Neuroscience, 2024<br><br>The latest version of the curated postsubiculum recordings (Dataset_1 and Dataset_2) is now published in NWB format on the DANDI Archive: https://dandiarchive.org/dandiset/000939<br>It is recommended that the DANDI version is used for all new analyses.<br><br>----------------------------<br>The dataset contains recordings made from postsubiculum (PoSub, also called dorsal presubiculum) and anterodorsal thalamic nucleus (ADN) in freely moving mice. Electrode placement was confirmed by histology. Many recording sessions (especially in Datasets 1, 2 and 3) include large ensembles of simultaneously recorded head-direction cells. The dataset is divided into 6 parts:<br><b>Dataset_1</b>: PoSub recordings with a 64-channel silicon probe. Open field exploration and sleep. Silicon probe implanted parallel to the cortical layers (20 degree angle from vertical plane), 17 recordings from 17 mice. Each recording folder in the above dataset contains three sub-folders:<br><br>· Data: files necessary for new analyses (spike times, mean waveforms, position, head direction, cell type classification, etc.)· Analysis: additional files related to analyses described in Duszkiewicz et al, 2024 (tuning curves, Fourier spectra, GLM coupling, Isomap projections, etc.)· Sleep: sleep scoring output of SleepScoreMaster (WAKE, REM and NREM epochs, pseudo-EMG, etc.)<br><b>Dataset_2</b>: PoSub recordings with a 64-channel silicon probe implanted vertically (across cortical layers). Open field exploration and sleep, 14 recordings from 14 mice. Each recording folder in the above dataset contains three sub-folders:<br><br>· Data: files necessary for new analyses (spike times, mean waveforms, position, head direction, cell type classification, etc.)· Analysis: additional files related to analyses described in Duszkiewicz et al, 2024 (tuning curves, Fourier spectra, GLM coupling, Isomap projections, etc.)· Sleep: sleep scoring output of SleepScoreMaster (WAKE, REM and NREM epochs, pseudo-EMG, etc.)<br><b>Dataset_ 3</b>: PoSub recordings with a 64-channel silicon probe implanted parallel to the cortical layers. Cue rotation task, 6 recordings from 6 mice. Regular open field recording sessions from all of these animals are included in Dataset 2. Each recording folder in the above dataset contains two sub-folders:<br><br>· Data: files necessary for analysis (spike times, mean waveforms, position, head direction, cell type classification, cue epoch intervals, etc.)· Analysis: additional files related to analyses described in Duszkiewicz et al, 2024 (tuning curves, Bayesian decoding, etc.)<br><b>Dataset_ 3b</b>: Extra cue rotation data not used in Duszkiewicz et al. (2024). PoSub recordings with a 64-channel silicon probe implanted parallel to the cortical layers. Cue rotation task, sessions where cue rotation did not induce reorientation, 5 recordings from 5 mice. Regular open field recording sessions from all of these animals are included in Dataset 2. Each recording folder in the above dataset contains two sub-folders:<br><br><br>· Data: files necessary for analysis (spike times, mean waveforms, position, head direction, cell type classification, cue epoch intervals, etc.)· Analysis: additional files related to analyses described in Duszkiewicz et al, 2024 (tuning curves, Bayesian decoding, etc.)<br><b>Dataset_4</b>: One RSC-PoSub recording session with a Neuropixel 1.0 silicon probe implanted parallel to the cortical layers (20 degree angle from vertical plane). Open field exploration and sleep. The recording folder in the above dataset contains two sub-folders:<br><br>· Data: files necessary for new analyses (spike times, mean waveforms, position, head direction, cell type classification, etc.)· Analysis: additional files related to analyses described in Duszkiewicz et al, 2024 (tuning curves, Fourier spectra, GLM coupling, Isomap projections, etc.)<br><b>Dataset_ 5</b>: ADN recordings with a 32-channel 4-shank silicon probe. Open field exploration and sleep, 19 recordings from 7 mice.<br><br>· Data: files necessary for analysis (spike times, mean waveforms, position, head direction, cell type classification, etc.)· Analysis: files related to analyses described in Duszkiewicz et al, 2024 (tuning curves, Fourier spectra, GLM coupling, Isomap projections, etc.)<br><b>Dataset_6</b>: PoSub and ADN recordings with several types of silicon probes (linear 64-channel or 4-shank 32-channel). Optogenetic inactivation of TRN input to ADN during open field exploration. Some of the sessions are also included in Datasets 1 and 5 (for analysis of HD tuning etc.). Each recording folder in the above dataset contains one sub-folder:<br><br>· Data: files necessary for new analyses (spike times, position, head direction, cell type classification, timestamps of optogenetic stimulation, etc.)<br>