cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.21456276.v1
title: Supplementary Material for: Increased Longevity of a Novel Gas Exchanger System for Low-Flow Veno-Venous Extracorporeal CO<sub>2</sub> Removal in Acute Hypercapnic Respiratory Failure

description: <b><i>Introduction:</i></b> Low-flow veno-venous extracorporeal CO<sub>2</sub> removal (ECCO<sub>2</sub>R) is an adjunctive therapy to support lung protective ventilation or maintain spontaneous breathing in hypercapnic respiratory failure. Low-flow ECCO<sub>2</sub>R is less invasive compared to higher flow systems, while potentially compromising efficiency and membrane lifetime. To counteract this shortcoming, a high-longevity system has recently been developed. Our hypotheses were that the novel membrane system provides runtimes up to 120 h, and CO<sub>2</sub> removal remains constant throughout membrane system lifetime. <b><i>Methods:</i></b> Seventy patients with pH ≤ 7.25 and/or PaCO<sub>2</sub> ≥9 kPa exceeding lung protective ventilation limits, or experiencing respiratory exhaustion during spontaneous breathing, were treated with the high-longevity ProLUNG system or in a control group using the original gas exchanger. Treatment parameters, gas exchanger runtime, and sweep-gas VCO<sub>2</sub> were recorded across 9,806 treatment-hours and retrospectively analyzed. <b><i>Results:</i></b> 25/33 and 23/37 patients were mechanically ventilated as opposed to awake spontaneously breathing in both groups. The high-longevity system increased gas exchanger runtime from 29 ± 16 to 48 ± 36 h in ventilated and from 22 ± 14 to 31 ± 31 h in awake patients (<i>p</i> &lt; 0.0001), with longer runtime in the former (<i>p</i> &lt; 0.01). VCO<sub>2</sub> remained constant at 86 ± 34 mL/min (<i>p</i> = 0.11). Overall, PaCO<sub>2</sub> decreased from 9.1 ± 2.0 to 7.9 ± 1.9 kPa within 1 h (<i>p</i> &lt; 0.001). Tidal volume could be maintained at 5.4 ± 1.8 versus 5.7 ± 2.2 mL/kg at 120 h (<i>p</i> = 0.60), and peak airway pressure could be reduced from 31.1 ± 5.1 to 27.5 ± 6.8 mbar (<i>p</i> &lt; 0.01). <b><i>Conclusion:</i></b> Using a high-longevity gas exchanger system, membrane lifetime in low-flow ECCO<sub>2</sub>R could be extended in comparison to previous systems but remained below 120 h, especially in spontaneously breathing patients. Extracorporeal VCO<sub>2</sub> remained constant throughout gas exchanger system runtime and was consistent with removal of approximately 50% of expected CO<sub>2</sub> production, enabling lung protective ventilation despite hypercapnic respiratory failure.
DOI: 10.6084/m9.figshare.21922452.v1
title: Supplementary Material for: Physicians’ Perceptions of Dietitians’ Services and Roles in Riyadh, Kingdom of Saudi Arabia

description: <b><i>Introduction:</i></b> Nutrition is a fundamental part of living a healthy lifestyle and is well-recognized in the prevention and treatment of several illnesses. The physicians’ collaboration according to their perception regarding the nutrition services and dietitian roles is important for optimal healthcare management. However, gaps exist in the knowledge and understanding of how the dietitian is perceived by physicians. To the researchers’ knowledge, this is the first study to assess the physicians’ perceptions regarding the role and services of dietitians in Riyadh city. <b><i>Method:</i></b> A cross-sectional study was conducted by using an anonymous self-administered online-based survey to investigate physicians’ perceptions regarding the role and services of dietitians. In addition to demographics, the questionnaire consisted of 20 statements that covered five domains of the dietitians’ scope of practice (Medical Nutrition Therapy, Legislation and Policy, Research and Interventions, Community Programs, and Sports Nutrition). A total of 407 participants were recruited between February and March 2021. Male and female medical physicians with different professional degrees who worked in Riyadh city were eligible to be included in the study. A cross-tabulation test was used to determine the difference among physicians regarding their perceptions of dietitians’ services and roles. <b><i>Results:</i></b> For all of the 20 statements that demonstrated dietitians’ services and roles, the mean score was classified as “strongly agree” with a mean of 4.33 (SD ± 0.541). There was a statistically significant relationship between physicians’ perceptions according to their nutritional background and two statements regarding dietitians’ clinical roles. In addition, there was also a statistically significant relationship between physicians’ perceptions who are not working in academia and three statements regarding dietitians’ clinical and nonclinical roles. <b><i>Conclusions:</i></b> This study’s findings support the importance of dietitians’ services in the healthcare setting as a multidisciplinary approach and recommend expanding dietitians’ employment opportunities outside the healthcare setting. Additionally, this study emphasizes incorporating nutrition education for physicians and demonstrates physicians’ understanding of nutrition as a discipline.
DOI: 10.6084/m9.figshare.24138681.v2
title: In cell ligand binding and G protein signalling (TRUPATH)

description: Ligand binding data for B1AR-W and B1AR-E in HEK cells. Siganlling data through verious G-protein pathways for B1AR-E and B1AR-W.
DOI: 10.6084/m9.figshare.3823068.v2
title: YorkU.Woodlot.Sept20-2016.CSV

description: This study was conducted to measure the diameter at breast height (dbh) of adult trees in pairs and the distance between them in woodlots, at York University around 3:30pm- 5:00pm.<br><br>Location: Data was collected at York University, at Keele St. and York Blvd, in the Woodlots.<br>Methods: In this field experiment, transects measuring tapes were used to determine the distance between 10 pairs of sugar maple trees. The diameters were measured from the middle of the tree trunks, using a tape measure. Canopy coverage was determined by making square with fingers and holding it up, in order to gain an estimate regarding how much of the sky was seen. <br>Key to variables: Diameter at breast height (dbh), distance to nearest species, and canopy coverage were continuous and quantitative variables. <br><br>Prediction: It was predicted that the distance between two trees with a low dbh would be less than those with a greater dbh, since the smaller the dbh, the smaller the tree and therefore, the less branches and canopy coverage it would have. Thus, the space it occupies would be less and the trees could form closer to each other.<br>Hypothesis: Tree pairs with lower dbh are closer to each other than pairs with greater dbh. Also canopy coverage is greater for trees with a higher dbh. <br>
DOI: 10.6084/m9.figshare.7947500.v1
title: gVCF_NA18552

description: 1000 Genomes gVCF mapped to hs37d5 for NA18552. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.11382099.v1
title: Appendix_sign._SNPs.xlsx

description: Wing morphology is an important trait underlying flight ability in winged insects. To investigate the genetic basis of wing morphology, we performed a genome-wide association study (GWAS) for additive and dominance effects on wing morphology and tibia length in an outbred population of the parasitoid wasp <i>Nasonia vitripennis</i>, using 1,230 individuals with genotypes for 8,639 SNPs. We found 46 SNPs in several distinct peaks across the genome with a genome-wide significant additive or dominance effect for wing morphology or tibia length.
DOI: 10.6084/m9.figshare.14283734.v1
title: Sign Languages as Languages of Interlocution: the Place of Communicative Activities in the School Context

description: ABSTRACT: The academic development of the deaf student depends on his/her mastery of a sign language. However, a sign language is not developed daily in the family environment; thus, this domain needs to be achieved in the school space, in which it is expected that the deaf student has peers in his/her language and can interact through it. All the same, the school environment has little tradition of working with the development of oral/sign language, focusing on activities with written language as a goal. Regarding the deaf student, little is discussed about the development of sign language in the school space. The bilingual teacher focuses his/her work on teaching the majority language as a second language in the written modality, working with sign language, without a clear proposal for the development of that language. Debates on practices to improve orality for the development of the hearing subject indicated the opportunity to reflect on these aspects in relation to deaf students. The focus of this paper is, therefore, on the debate on this theme, aiming at the training of teachers to improve the uses of sign language in the school space.
DOI: 10.6084/m9.figshare.5885230.v1
title: GHWR - Threshold - ETCCDI, PDF, SHI, and Summer Methods

description: Localized threshold for heatwaves using ETCCDI, PDF and Summer methods. It also provides SHI (Standardized Heat Index) record for the entire globe between 1979 and 2017.
DOI: 10.6084/m9.figshare.27716682.v1
title: Questionnaire survey.pdf

description: Organ donation remains low when it is not accompanied by a good knowledge and positive attitude. Most published articles have evaluated organ donation knowledge and attitudes within single categories such as healthcare workers, students, or patients. Few studies have assessed these factors across various job categories.
DOI: 10.6084/m9.figshare.8139203.v1
title: Supplementary Material for: Atopic Patients Show Increased Interleukin 4 Plasma Levels but the Degree of Elevation Is Not Sufficient to Upregulate Interleukin-4-Sensitive Genes

description: <b><i>Background:</i></b> Atopic diseases constitute a major health challenge for industrialized countries, and elevated levels of interleukin 4 (IL-4) frequently characterize these disorders. Previous in vitro<i></i>analyses have indicated that IL-4 strongly upregulates the expression of IL-4-sensitive genes in human monocytes. <b><i>Objective:</i></b> To explore whether similar expression alterations may contribute to the pathomechanisms of atopic diseases in vivo we carried out a small-scale case-control clinical study (<i>n</i> = 43), in which we quantified the plasma levels of IgE and IL-4 as well as the expression of selected IL-4-sensitive genes in blood leukocytes. <b><i>Methods:</i></b> 34 allergic patients suffering from allergic rhinitis (<i>n</i> = 11), atopic eczema (<i>n</i> = 11) and allergic asthma (<i>n</i> = 12) as well as 9 healthy control individuals were recruited. IgE and IL-4 plasma levels were determined by ELISA, and the expression of selected IL-4-sensitive gene products in blood leukocytes was quantified by qRT-PCR. In addition, the fatty acid oxygenase activity of isolated monocytes was measured by RP-HPLC analysis of the arachidonic acid oxygenation products (ex vivo activity assays). <b><i>Results:</i></b> We found that plasma levels of IgE and IL-4 were significantly elevated in atopic patients but the degree of elevation was not sufficient to upregulate the expression of the selected IL-4-sensitive genes in circulating leukocytes. Moreover, the arachidonic acid oxygenase activity of blood monocytes was not significantly altered in atopic patients. <b><i>Conclusion:</i></b> Our data suggest that the IL-4 plasma levels of atopic patients are not high enough to impact the expression of IL-4-sensitive genes.
DOI: 10.6084/m9.figshare.19487837.v3
title: High diversity of type I polyketide genes in Bacidia rubella as revealed by the comparative analysis of 23 lichen fungal genomes

description: gff3, protein and contig fasta files for 23 fungal studied genomes; PKS Type I alignment used for the phylogeny; PKS tree with the support values of the trees<br>
DOI: 10.17632/ww7cn44dwk
title: Evaluating the impact of different agropastoral practices on wind erosion in western Sahel (dataset)

description: Agricultural plot monitoring dataset associated with Research Paper : 10.5281/zenodo.14639791
It contains, weather, horizontal flux and vegetation monitoring for one groudnut plot, four fallows and four millet plots
DOI: 10.6084/m9.figshare.14401391.v2
title: Lifespan-associated gene expression signatures of recombinant BXD mice implicates Coro7 and Set in longevity

description: Supplementary Figures 1-4 and Supplementary Tables 1-7
DOI: 10.17044/scilifelab.13280867.v1
title: Association of CSF proteins with tau and amyloid β levels in asymptomatic 70-year-olds

description: <strong>Abstract</strong>
Increased knowledge of the evolution of molecular changes in neurodegenerative disorders such as Alzheimer’s disease (AD) is important for the understanding of disease pathophysiology and also crucial to be able to identify and validate disease biomarkers. While several biological changes that occur early in the disease development have already been recognised, the need for further characterization of the pathophysiological mechanisms behind AD still remains.
<br>
In this study, we investigated cerebrospinal fluid (CSF) levels of 104 proteins in 307 asymptomatic 70-year-olds from the H70 Gothenburg Birth Cohort Studies using a multiplexed antibody-based technology.
<br>
The protein levels were first correlated with the core AD CSF biomarker concentrations of total tau, phospho-tau and Aβ42 in all individuals. Sixty-three proteins showed significant correlations with either total tau, phospho-tau or Aβ42. Thereafter, individuals were divided based on CSF Aβ42/Aβ40 ratio and Clinical Dementia Rating (CDR) score to determine if early changes in pathology and cognition had an effect on the correlations. We compared the associations of the analysed proteins to CSF markers between groups and found 33 proteins displaying significantly different associations for amyloid-positive individuals and amyloid negative individuals, as defined by the CSF Aβ42/Aβ40 ratio. No differences in the associations could be seen for individuals divided by CDR score.
<br>
We identified a series of transmembrane proteins, proteins associated to or anchored to the plasma membrane, and proteins involved in or connected to synaptic vesicle transport that were associated with CSF biomarkers of amyloid and tau pathology in AD. Further studies are needed to explore their role in AD pathophysiology.
<br>
<strong>Data Access Statement</strong>
The dataset contains relative protein levels as well as CSF concentrations of amyloid beta and tau which constitutes sensitive personal information that fall under GDPR. Therefore, access to data and related code is restricted. The data can be made available upon reasonable request, in accordance with GDPR and other regulations regarding data sharing.
<br>
A reasonable request should contain:<br>
1) Name of PI and host organisation<br>
2) Contact details<br>
3) Scientific purpose of data access request<br>
4) Commitment to inform when the data has been used in a publication<br>
5) Commitment not to host or share the data outside the requesting organisation<br>
6) Statement of non-commercial use of data
<br>
DOI: 10.6084/m9.figshare.14779533.v1
title: Upscaling the resilience assessment through comparative analysis

description: Dataset accompanying the paper "Upscaling the resilience assessment through comparative analysis". The data codes features of adaptive capacity for 40 Arctic communities. The analysis uses QCA (qualitative comparative analysis) to identify necessary and sufficient conditions for communities to maintain their livelihoods. The code for the analysis is available at https://github.com/juanrocha/Arctic_QCAThe zip file contains the 40 templates developed to describe cases. The templates are based on literature review and expert elicitation. For more information see the preprint available in SocArxiv.
DOI: 10.6084/m9.figshare.21136909.v1
title: NovaSeq Robust Subtype Assignment

description: This file contains the results from 11 separate rounds of NMF clustering in the NovaSeq ALS cohort.
DOI: 10.17605/osf.io/3zjbg
title: Beyond Hawks and Doves -- replication files

description: replication files for the paper "Beyond Hawks and Doves: can inequality ease coordination?"
DOI: 10.17632/6z9nkzys4v
title: Ultrasound Mediated Microbubble Sonoporation

description: CEUS examination of 20L5: enhance from CEUS timer 00:00:22, wash out at 00:00:50.
DOI: 10.6084/m9.figshare.19499126.v1
title: patches and local annotations, slide 197, zoom 248x248 um2

description: patches and local annotations: data for slide with ID of the last 3 characters of the file name: local annotations in csv format and a folder with patches at zoom level indicated at the 6th character of the file name
DOI: 10.6084/m9.figshare.22580299.v1
title: Datasets from erythrocyte experiments

description: This folder consists of data collected from different erythrocyte treatment experiments.
DOI: 10.6084/m9.figshare.25021103.v2
title: Multi-taxa responses to climate change in the Amazon forest

description: Data and code from 'Multi-taxa responses to climate change in the Amazon forest'. Authors: Carlos A. S. Rodrigues-Filho; Flávia R. C. Costa; Juliana Schietti;<sup> </sup>Anselmo Nogueira; Rafael Pereira Leitão;<sup> </sup>Juliana Menger;<sup> </sup>Gabriel Borba; Caian Souza Gerolamo; Stefano S. Avilla;<sup> </sup>Thaise Emilio;<sup> </sup>Carolina Volkmer de Castilho; Douglas Aviz Bastos; Elisangela Xavier Rocha; Itanna O. Fernandes; Cintia Cornelius; Jansen Zuanon; Jorge L. P. Souza; Ana C. S. Utta<sup>1</sup>; Fabricio B. Baccaro
DOI: 10.17632/y877stnvgd
title: Video laryngoscopic intubation using the King VisionTM laryngoscope in a simulated cervical spine trauma: a comparison between non-channeled and channeled disposable blades

description: Raw data for the simulation study: Video laryngoscopic intubation using the King VisionTM laryngoscope in a simulated cervical spine trauma: a comparison between non-channeled and channeled disposable blades - excel table, detailed description of statistical methods used
DOI: 10.6084/m9.figshare.14442194.v1
title: OX_heart_CDS_representative.fa.gz

description: OX_heart representative CDS sequences
DOI: 10.6084/m9.figshare.1543418.v1
title: Layer 1 cells

description: Models of Layer 1 cells. Based on Blue Brain Project cells
DOI: 10.6084/m9.figshare.25486396.v1
title: Supplementary Material for: Introducing exome sequencing as part of the diagnostic algorithm for pediatric nephrology patients in Bulgaria - a single-center experience

description: INTRODUCTION: In pediatric kidney patients, where clinical presentation is often not fully developed and renal biopsy too risky or inconclusive, it may be difficult to establish the underlying pathology. In cases such as these, genetic diagnosis may be used to guide the treatment, prognosis and counselling. Given the large number of genes involved in kidney disease, introducing next generation sequencing with extended gene panels as part of the diagnostic algorithm presents a viable solution.
METHODS: A cohort of 87 consecutive independent cases (83 children and 4 terminated pregnancies) with renal disease were recruited. Exome sequencing with MiSeq or NovaSeq 6 000 (Illumina) platforms and analysis of extended gene panels was used for genetic testing. 
RESULTS: Depending on the presenting pathology, the cases were grouped as patients with glomerular disease, ciliopathies, congenital anomalies, renal electrolyte imbalances and chronic/acute kidney disease. The overall diagnostic yield was app. 42% (37 out of 87) with most disease-causing mutations found in COL4A3, COL4A4, COL4A5 and PKHD1 genes. A change or clarification of preliminary diagnosis, or adjustment of initial treatment plan based on the results from the genetic testing was made for app. one third of the children with meaningful genetic findings (11 out 37).
DISCUSSION: Our results prove the value of targeted exome sequencing as non-invasive, versatile and reliable diagnostic tool for pediatric renal disease patients. Providing genetic diagnosis will help for better understanding of disease etiology and will give basis for optimal clinical management and insightful genetic counseling.
DOI: 10.6084/m9.figshare.28330418.v1
title: OL_CASE REPORT

description: This document contains a series of <b>exercises specifically designed to improve auditory comprehension, sequential auditory memory, auditory association, grammatical integration, auditory integration, verbal expression, and vocabulary</b>. Each activity includes a specific objective, detailed instructions, required materials, and variations to adjust the difficulty level. These strategies are tailored for a unique case, addressing specific difficulties in auditory processing and language skills. The exercises provide practical tools to enhance cognitive and linguistic abilities, making them ideal for language therapists, educators, and neuropsychology specialists working with this individual.
DOI: 10.6084/m9.figshare.21757856.v3
title: RAW DATA.docx

description: <strong>Project Description Details</strong> <strong>The sources for this data are collected from https://www.maybelline.co.id/, https://www.loreal.co.id/. The research is primarily focused on examining Maybelline New York advertisements. Data were gathered using an observational methodology. The researcher examined the advertisements by searching for them on Google to download the complete text of the advertisements </strong> <br> <br> (1) To increase sensitivity to the mood structure depicted in the Maybelline New York beauty advertisement. (2) It is harder to find interrogative statements than declarative ones. We can observe the many mood structure kinds and their applications to make things simpler. Research is conducted using descriptive qualitative methods. The research in this instance provides methodical, factual, and reliable information regarding the facts and causal connections of the phenomena under study.
DOI: 10.6084/m9.figshare.24248944.v1
title: RepEnTools-Galaxy instructions, workflows, and spreadsheet

description: <i>RepEnTools</i> - Galaxy instructions, workflows, and spreadsheetWe include the spreadsheet necessary for using RepEnTools in Galaxy, the workflows "Part 1" and "Part 2", step-by-step instructions for simple use (basic), and an illustration for them. FAQs and special Considerations when using RepEnTools are discussed in the corresponding pdf files.A workflow for single-end FASTQ data is also included, please read the FAQ before use.We also include the workflow "Part 3" , which we used to generate the RE-specific heatmaps and profile visualisations in our publication, detailed step-by-step instructions for use (extended), and the matching illustration.