cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.30834343
title: Decreased production of antiviral factors in patients infected with SARS-CoV-2 due to reduced TLR7 expression

description: The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pandemic presents a major global health challenge. Innate immunity is a key defense against viral infections and influences disease progression. Similar to SARS-CoV-1, which can suppress interferon (IFN) production to evade the immune response, SARS-CoV-2 May also impair antiviral pathways. To investigate this, we analyzed the expression of interferon-stimulated genes (ISGs) in 48 SARS-CoV-2-infected patients using real-time polymerase chain reaction (RT-qPCR) and assessed toll-like receptor (TLR7) expression in blood cells via flow cytometry. Results showed that infected individuals had reduced baseline expression of antiviral factors and a diminished response to stimulation with a TLR7/8 agonist (CL097), compared to healthy individuals. A decrease in pattern recognition receptors (PRRs) was also observed at both the gene and protein levels. These findings support the hypothesis that SARS-CoV-2 disrupts the IFN signaling pathway, similar to SARS-CoV-1. Reduced expression of innate immune receptors appears to impair the production of antiviral molecules, potentially delaying viral clearance and worsening disease outcomes. This highlights the importance of innate immune regulation in SARS-CoV-2 infection and may help inform future therapeutic strategies. The virus that causes coronavirus disease 2019 (COVID-19), severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has a way of weakening the body’s early immune defense, called the innate immune system. This system is supposed to act fast, recognizing viruses and sending out signals to fight them before they spread too much. In people infected with SARS-CoV-2, scientists noticed that certain important genes – called interferon-stimulated genes – and sensors like toll-like receptor (TLR7), which help detect viruses, are less active than usual. These parts of the immune system don’t turn on properly, even when scientists try to trigger them using lab tools. This means the virus is interfering with the interferon signaling pathway, which is like the body’s alarm system for viral infections. If this alarm system doesn’t work, the immune response is delayed, and the virus can spread more easily in the body. That may lead to more severe illness in some people.
DOI: 10.6084/m9.figshare.30834343.v1
title: Decreased production of antiviral factors in patients infected with SARS-CoV-2 due to reduced TLR7 expression

description: The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pandemic presents a major global health challenge. Innate immunity is a key defense against viral infections and influences disease progression. Similar to SARS-CoV-1, which can suppress interferon (IFN) production to evade the immune response, SARS-CoV-2 May also impair antiviral pathways. To investigate this, we analyzed the expression of interferon-stimulated genes (ISGs) in 48 SARS-CoV-2-infected patients using real-time polymerase chain reaction (RT-qPCR) and assessed toll-like receptor (TLR7) expression in blood cells via flow cytometry. Results showed that infected individuals had reduced baseline expression of antiviral factors and a diminished response to stimulation with a TLR7/8 agonist (CL097), compared to healthy individuals. A decrease in pattern recognition receptors (PRRs) was also observed at both the gene and protein levels. These findings support the hypothesis that SARS-CoV-2 disrupts the IFN signaling pathway, similar to SARS-CoV-1. Reduced expression of innate immune receptors appears to impair the production of antiviral molecules, potentially delaying viral clearance and worsening disease outcomes. This highlights the importance of innate immune regulation in SARS-CoV-2 infection and may help inform future therapeutic strategies. The virus that causes coronavirus disease 2019 (COVID-19), severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has a way of weakening the body’s early immune defense, called the innate immune system. This system is supposed to act fast, recognizing viruses and sending out signals to fight them before they spread too much. In people infected with SARS-CoV-2, scientists noticed that certain important genes – called interferon-stimulated genes – and sensors like toll-like receptor (TLR7), which help detect viruses, are less active than usual. These parts of the immune system don’t turn on properly, even when scientists try to trigger them using lab tools. This means the virus is interfering with the interferon signaling pathway, which is like the body’s alarm system for viral infections. If this alarm system doesn’t work, the immune response is delayed, and the virus can spread more easily in the body. That may lead to more severe illness in some people.
DOI: 10.3535/hna-n5g-eqr
title: Brenthis ino (von Rottemburg, 1775)

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.6084/m9.figshare.30491150
title: A molecular docking and glycoinformatics approach reveals viral NS4A–human Sec61G interaction in Zika/Dengue infections

description: Zika (ZIKV) and Dengue virus (DENV) are transmitted to humans via Aedes mosquitoes, collectively infecting approximately 400 million individuals annually. Both viruses replicate on the endoplasmic reticulum membrane, where the NS4A protein serves as a key component of the viral replication complex and mediates interactions with the host Sec61G protein. Although host glycosylation enzymes have been reported to interact with NS4A, the three-dimensional structure of NS4A, potential glycosylation sites, precise interaction interfaces with Sec61G, and the functional role of glycosylation in these interactions remain largely unknown. This study aims to characterize the molecular determinants of NS4A – Sec61G interactions to provide insights into virus-host interactions. Structures of NS4A proteins were predicted via molecular modeling. Glycosylation sites were identified using glycoinformatics analyses, and NS4A – Sec61G interactions were assessed using three distinct molecular docking programs to ensure reliability and cross-validation of predicted binding modes. Glycosylation analysis revealed that only NS4A from ZIKV contains O-glycosylation sites. Docking simulations highlighted Arg127 in NS4A ZIKV, and Arg76 and Glu124 in NS4A DENV as critical residues potentially mediating stable interactions with Sec61G. These residues likely play essential roles in NS4A – Sec61G interactions, and their identification may contribute to the development of effective therapeutic strategies targeting both viral and host factors.
DOI: 10.6084/m9.figshare.30491150.v3
title: A molecular docking and glycoinformatics approach reveals viral NS4A–human Sec61G interaction in Zika/Dengue infections

description: Zika (ZIKV) and Dengue virus (DENV) are transmitted to humans via Aedes mosquitoes, collectively infecting approximately 400 million individuals annually. Both viruses replicate on the endoplasmic reticulum membrane, where the NS4A protein serves as a key component of the viral replication complex and mediates interactions with the host Sec61G protein. Although host glycosylation enzymes have been reported to interact with NS4A, the three-dimensional structure of NS4A, potential glycosylation sites, precise interaction interfaces with Sec61G, and the functional role of glycosylation in these interactions remain largely unknown. This study aims to characterize the molecular determinants of NS4A – Sec61G interactions to provide insights into virus-host interactions. Structures of NS4A proteins were predicted via molecular modeling. Glycosylation sites were identified using glycoinformatics analyses, and NS4A – Sec61G interactions were assessed using three distinct molecular docking programs to ensure reliability and cross-validation of predicted binding modes. Glycosylation analysis revealed that only NS4A from ZIKV contains O-glycosylation sites. Docking simulations highlighted Arg127 in NS4A ZIKV, and Arg76 and Glu124 in NS4A DENV as critical residues potentially mediating stable interactions with Sec61G. These residues likely play essential roles in NS4A – Sec61G interactions, and their identification may contribute to the development of effective therapeutic strategies targeting both viral and host factors.
DOI: 10.3535/2cy-z4j-cvs
title: Issoria lathonia (Linnaeus, 1758)

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/kj1-5zk-f7a
title: Xestia (Pachnobia) distensa Eversmann, 1851

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.6084/m9.figshare.30491150.v2
title: A molecular docking and glycoinformatics approach reveals viral NS4A–human Sec61G interaction in Zika/Dengue infections

description: Zika (ZIKV) and Dengue virus (DENV) are transmitted to humans via Aedes mosquitoes, collectively infecting approximately 400 million individuals annually. Both viruses replicate on the endoplasmic reticulum membrane, where the NS4A protein serves as a key component of the viral replication complex and mediates interactions with the host Sec61G protein. Although host glycosylation enzymes have been reported to interact with NS4A, the three-dimensional structure of NS4A, potential glycosylation sites, precise interaction interfaces with Sec61G, and the functional role of glycosylation in these interactions remain largely unknown. This study aims to characterize the molecular determinants of NS4A – Sec61G interactions to provide insights into virus-host interactions. Structures of NS4A proteins were predicted via molecular modeling. Glycosylation sites were identified using glycoinformatics analyses, and NS4A – Sec61G interactions were assessed using three distinct molecular docking programs to ensure reliability and cross-validation of predicted binding modes. Glycosylation analysis revealed that only NS4A from ZIKV contains O-glycosylation sites. Docking simulations highlighted Arg127 in NS4A ZIKV, and Arg76 and Glu124 in NS4A DENV as critical residues potentially mediating stable interactions with Sec61G. These residues likely play essential roles in NS4A – Sec61G interactions, and their identification may contribute to the development of effective therapeutic strategies targeting both viral and host factors.
DOI: 10.6084/m9.figshare.30499776
title: Gender inequities regarding the HPV vaccination coverage in high-income countries: a systematic review and meta-analysis

description: Gender-neutral HPV vaccination is the most effective method for cervical cancer elimination and reduces the burden of HPV-associated cancers. This systematic review aims to analyze gender inequities in the HPV vaccine uptake in high-income countries. Electronic databases and official websites were searched using specific search terms for articles published between January 2010 and 2025. The systematic review was reported based on the updated Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) checklist. The meta-analysis component was modified appropriately to synthesize the pooled prevalence of the HPV vaccine uptake among adolescents, men having sex with men and transgender persons with 95% confidence interval (CI). Higher HPV vaccine uptake was observed among adolescent girls in comparison to boys in high-income countries. Meanwhile, the HPV vaccine uptake among gender diverse individuals was minimal. Substantial gender inequities exist in the HPV vaccination coverage among adolescents and young adults from high-income countries. However, the data among gender diverse individuals were retrieved from small clinic-based studies in the USA and may not be generalizable to all gender diverse individuals. https://www.crd.york.ac.uk/PROSPERO/view/CRD42025641689.
DOI: 10.6084/m9.figshare.30499776.v1
title: Gender inequities regarding the HPV vaccination coverage in high-income countries: a systematic review and meta-analysis

description: Gender-neutral HPV vaccination is the most effective method for cervical cancer elimination and reduces the burden of HPV-associated cancers. This systematic review aims to analyze gender inequities in the HPV vaccine uptake in high-income countries. Electronic databases and official websites were searched using specific search terms for articles published between January 2010 and 2025. The systematic review was reported based on the updated Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) checklist. The meta-analysis component was modified appropriately to synthesize the pooled prevalence of the HPV vaccine uptake among adolescents, men having sex with men and transgender persons with 95% confidence interval (CI). Higher HPV vaccine uptake was observed among adolescent girls in comparison to boys in high-income countries. Meanwhile, the HPV vaccine uptake among gender diverse individuals was minimal. Substantial gender inequities exist in the HPV vaccination coverage among adolescents and young adults from high-income countries. However, the data among gender diverse individuals were retrieved from small clinic-based studies in the USA and may not be generalizable to all gender diverse individuals. https://www.crd.york.ac.uk/PROSPERO/view/CRD42025641689.
DOI: 10.7910/dvn/welgxo
title: RCSB PDB 5GGS: PD-1 in complex with pembrolizumab Fab, 310K, 37°C, 500 ns: random seed #1

description: RCSB PDB 5GGS: PD-1 in complex with pembrolizumab Fab, 310K, 37°C, 500 ns: random seed #1. PDBs obtained every 50 ns.
DOI: 10.3535/jn4-f4y-y4n
title: Mniotype satura [Denis & Schiffermüller], 1775

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/nfl-g6c-nmt
title: Pararge Hübner, 1819

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/fwa-vwe-xtm
title: Speyeria aglaja (Linnaeus, 1758)

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/pkn-dvc-tae
title: Hypena rostralis (Linnaeus, 1758)

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/rey-mv2-gck
title: Hypena rostralis (Linnaeus, 1758)

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/v30-kgm-j16
title: Colias palaeno (Linnaeus, 1761)

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/bqj-rfa-xev
title: Mniotype satura [Denis & Schiffermüller], 1775

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/cxn-mvm-ems
title: Mniotype satura [Denis & Schiffermüller], 1775

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/05k-4bs-bfh
title: Lacanobia (Dianobia) suasa [Denis & Schiffermüller], 1775

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/b33-a9x-4ca
title: Crambus nemorella Hübner

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/e8e-mct-0dp
title: Plebejus argus (Linnaeus, 1758)

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/f8l-arj-8rk
title: Polia vesperugo Eversmann, 1856

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/qq2-lje-etx
title: Eumedonia eumedon (Esper, 1780)

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/ylm-qq4-vxs
title: Animalia

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/ag4-h7z-ql5
title: Polygonia c-album (Linnaeus, 1758)

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/fya-86w-f5c
title: Mniotype satura [Denis & Schiffermüller], 1775

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/qh0-9bt-mpk
title: Eurois occulta Linnaeus, 1758

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/vmv-c5c-g6d
title: Erebia lappona Thunberg, 1791

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/l38-1eh-v34
title: Calamia tridens Hufnagel, 1766

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/ag7-8m9-d61
title: Agrotis ipsilon (Hufnagel, 1766)

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/zyb-21c-jqe
title: Boloria Moore, 1900

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/24b-8x2-ky7
title: Furcula bifida (Brahm, 1787)

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/b0y-m15-avh
title: Issoria lathonia (Linnaeus, 1758)

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/5g8-p8t-xzc
title: Depressaria sordidatella Tengström, 1848

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/ee0-x0n-7ks
title: Coenonympha pamphilus (Linnaeus, 1758)

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/r1z-h5r-b9b
title: Pieris napi (Linnaeus, 1758)

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/0jv-yxy-ls5
title: Xestia (Pachnobia) distensa Eversmann, 1851

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/b1p-0b1-chc
title: Melitaea athalia von Rottemburg, 1775

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/ljh-qey-78a
title: Catoptria margaritellus [Denis & Schiffermüller], 1775

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/pvp-9pv-gpj
title: Leucania (Leucania) comma Linnaeus, 1761

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/l5a-8bt-e3c
title: Udea lutealis Hübner, 1809

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.15468/dl.33yera
title: Occurrence Download

description: A dataset containing 121 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Continent is one of (Asia, Oceania, Europe, North America)",
 "DatasetKey is one of (International Barcode of Life project (iBOL), University of Hawaii Insect Museum, Lepidoptera World (Luomus) (LEPW), INSDC Sequences, Taiwan Moth Occurrence Data Collected From Social Network, Mississippi Entomological Museum, Data-set of Moth Specimen from TESRI, NMNH Material Samples (USNM))",
 "OccurrenceStatus is Present",
 "TaxonKey is Hypena laceratalis"
 ]
}

 The dataset includes 121 records from 7 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0056211-251120083545085/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.3535/rcd-5g5-nck
title: Cryptoblabes bistriga Haworth, 1811

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/71s-s2a-6jf
title: Ochlodes Scudder, 1872

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/eqj-vg9-f1d
title: Fabriciana niobe (Linnaeus, 1761)

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/2j2-kkd-0wc
title: Hyppa rectilinea (Esper, 1788)

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/fgm-nkr-dnx
title: Agrotis ipsilon (Hufnagel, 1766)

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/y7q-vd3-7dp
title: Boloria Moore, 1900

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/pme-782-m2d
title: Pieris napi (Linnaeus, 1758)

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/vv5-yjq-znx
title: Phyllodesma (Phyllodesma) ilicifolia (Linnaeus, 1758)

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/7l9-pz4-njg
title: Polia hepatica Clerck, 1759

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/l3g-skf-61d
title: Euxoa (Euxoa) nigricans Linnaeus, 1761

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/phy-j12-geq
title: Gluphisia crenata (Esper, 1785)

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/6rt-q16-xa0
title: Colias palaeno (Linnaeus, 1761)

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/qh0-ppw-htq
title: Pieris napi (Linnaeus, 1758)

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/790-0db-cxt
title: Issoria lathonia (Linnaeus, 1758)

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/lb8-hxd-jtl
title: Autographa bractea ([Denis & Schiffermüller], 1775)

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/24b-de4-60k
title: Issoria lathonia (Linnaeus, 1758)

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/e3j-pfc-akb
title: Pieris napi (Linnaeus, 1758)

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/p91-39r-x1c
title: Crambus pratella Linnaeus, 1758

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.5281/zenodo.17961976
title: TPFRS (Skala Czynników Ochronnych Resilience Nauczycieli) – zbiór danych i metadanych, polska adaptacja

description: Repozytorium zawiera polską wersję Skali Czynników Ochronnych Resilience Nauczycieli (TPFRS-PL) oraz jej metadane. Dane zostały zebrane w ramach badania walidacyjnego narzędzia TPFRS w Polsce w ramach projektu NCN Miniatura 8 (2024/08/X/HS6/01067).

Zawarte pliki:





TPFRS-PL_baza_danych.sav – baza danych w formacie SPSS z odpowiedziami uczestników.




Metadane dla TPFRS-PL.pdf – dokument opisujący zmienne oraz kodowanie odpowiedzi.



Dane są anonimowe i mogą być wykorzystane do analiz psychometrycznych oraz dalszych badań nad rezyliencją nauczycieli.
DOI: 10.3535/3aa-xae-kx5
title: Hypena rostralis (Linnaeus, 1758)

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/jtx-mly-g2x
title: Lacanobia (Dianobia) suasa [Denis & Schiffermüller], 1775

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.