cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.25373/ctsnet.7757375.v1
title: Surgery for Chronic Thromboembolic Pulmonary Hypertension: Thromboendarterectomy of the Pulmonary Artery

description: <b>Introduction</b> Chronic thromboembolic pulmonary hypertension (CTEPH) is caused by proximal pulmonary artery thromboembolic occlusion or obstruction. Patients present with shortness of breath, early fatigue, and decreased exercise capacity. Once the obstruction sets in, it is accompanied by remodeling of the branches of the pulmonary artery. This causes pulmonary artery hypertension and subsequently leads to right ventricular (RV) dysfunction, which eventually leads to RV failure [1]. The American Heart Association makes a class 1 recommendation that indicates CTEPH should be promptly evaluated for pulmonary endarterectomy, even if symptoms are mild [1].Pulmonary thromboendarterectomy is a potentially curative surgery for CTEPH. The incidence is estimated to be between one and five percent among survivors of acute pulmonary embolism (PE) [2]. However, diagnostic data from echocardiography and computed tomography (CT) scans done when PE is first diagnosed suggest that many patients with CTEPH have undiagnosed pulmonary hypertension. This may indicate that the first clinical presentation of CTEPH may present as acute PE [3]. Apart from pulmonary embolism, hypercoagulable states may be the etiology of this disease.<br> Medical therapy is aimed at lowering the resistance of and pressure in pulmonary vessels. This includes vasodilators and drugs inducing remodeling of the vessels. It does improve symptoms such as exercise intolerance and oxygen desaturation. Medical therapy is not curative, and its effects are relatively modest [4]. Surgery is the only definitive therapy for CTEPH, and pulmonary thromboendarterectomy is the surgical procedure of choice.<br> <b>Patient History</b> The authors present a case of CTEPH. The patient was a 35-year-old man presenting as an outpatient with complaints of severe progressive dyspnea. He was diagnosed with pulmonary embolism in the past and has been on anticoagulation for more than three years. He has had CT scans and chest x-rays in between. Multiple transthoracic echocardiograms have been performed with evidence of slowly declining right ventricular function. This time, he presented to the cardiac surgery service with a severely dilated and dysfunctional right ventricle. He had been on diuretics and vasodilator treatment but had mild to no improvement. After a thorough review, the authors decided to perform a pulmonary thromboembolectomy. The CT scan images show a dilated RV and intravenous contrast reflux in the inferior vena cava (Figures 1-4). The thrombus can be seen starting in the main pulmonary artery and almost completely occluding it. The thrombus extends into the bilateral pulmonary arteries.<br>Learn more: https://www.ctsnet.org/article/surgery-chronic-thromboembolic-pulmonary-hypertension-thromboendarterectomy-pulmonary-artery
DOI: 10.7284/108475
title: CTD (Conductivity, Temperature, Depth) data collected during research cruise AE1132 using a Sea-Bird SBE-911+ instrument system onboard the platform RV Atlantic Explorer

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7757357
title: Data set for paper on 'Charitable giving when donors are constrained to give a minimum amount'

description: This is the data for the paper on 'Charitable giving when donors are constrained to give a minimum amount' published in Oxford Economic Papers 2019
DOI: 10.6084/m9.figshare.7757363.v1
title: HEV supplementary alignment

description: <b>Supplementary Alignment.</b> Alignment built using the nucleotide sequences generated by Sanger and HTS and the sequences corresponding to the whole genome and the ORF2 gene of the Strain_B1_Burma_(Genbank accession number M73218, Subtype_1A).
DOI: 10.6084/m9.figshare.7757357.v1
title: Data set for paper on 'Charitable giving when donors are constrained to give a minimum amount'

description: This is the data for the paper on 'Charitable giving when donors are constrained to give a minimum amount' published in Oxford Economic Papers 2019
DOI: 10.7284/108473
title: Fluorometer data collected during research cruise AE1132 using a Turner 10-AU instrument system onboard the platform RV Atlantic Explorer

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/106552
title: GNSS (Global Navigation Satellite System) data collected during research cruise AE1132 using a Furuno GP-90 instrument system onboard the platform RV Atlantic Explorer

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/108471
title: TSG (Thermosalinograph) data collected during research cruise AE1132 using a Sea-Bird SBE-21 instrument system onboard the platform RV Atlantic Explorer

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/108472
title: Winch data collected during research cruise AE1132 using a Markey DUSH-5 instrument system onboard the platform RV Atlantic Explorer

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/111603
title: CTD (Conductivity, Temperature, Depth) data collected during research cruise AE1201 using a Sea-Bird SBE-911+ instrument system onboard the platform RV Atlantic Explorer

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7757108
title: Proton pump inhibitors therapy and the risk of pneumonia: a systematic review and meta‐analysis of randomized controlled trials and observational studies

description: <b>Objective</b>: We aimed to summarize the current evidence regarding the risk of pneumonia associated with proton pump inhibitors (PPI) treatment. <b>Methods</b>: We searched PubMed, Embase, and CENTRAL from the 1970 through December 2017. We included both randomized controlled trials (RCTs) and observational studies. We used random-effect model to calculate the summary effect estimates and quantified the heterogeneity by <i>I<sup>2</sup></i> statistics. <b>Results</b>: A total of 7,643,982 patients from 10 RCTs and 48 observational studies were included in this meta-analysis. The primary meta-analysis demonstrated PPIs use was significantly associated with increased risk of pneumonia, but the heterogeneity was high (odds ratio [OR], 1.43; 95% confidence interval [CI], 1.30–1.57; <i>I</i><sup>2</sup>, 95.4%). The sensitivity analysis indicated PPIs were not statistically associated with increased risk of pneumonia among patients concomitantly taking nonsteroidal anti-inflammatory drugs (OR, 1.11; 95% CI, 0.94–1.31; <i>I</i><sup>2</sup>, 5.8%). The funnel plot demonstrated significant publication bias, especially for observational studies. <b>Conclusions</b>: The presence of significant between-study heterogeneity and publication bias raised concerns regarding the validity of the primary meta-analytic result. Protopathic bias, or reverse causality, may cause overestimated association. Studies that adopted a design to account for protopathic bias did not show a significant association between PPI use and risk of pneumonia.
DOI: 10.6084/m9.figshare.7757108.v1
title: Proton pump inhibitors therapy and the risk of pneumonia: a systematic review and meta‐analysis of randomized controlled trials and observational studies

description: <b>Objective</b>: We aimed to summarize the current evidence regarding the risk of pneumonia associated with proton pump inhibitors (PPI) treatment. <b>Methods</b>: We searched PubMed, Embase, and CENTRAL from the 1970 through December 2017. We included both randomized controlled trials (RCTs) and observational studies. We used random-effect model to calculate the summary effect estimates and quantified the heterogeneity by <i>I<sup>2</sup></i> statistics. <b>Results</b>: A total of 7,643,982 patients from 10 RCTs and 48 observational studies were included in this meta-analysis. The primary meta-analysis demonstrated PPIs use was significantly associated with increased risk of pneumonia, but the heterogeneity was high (odds ratio [OR], 1.43; 95% confidence interval [CI], 1.30–1.57; <i>I</i><sup>2</sup>, 95.4%). The sensitivity analysis indicated PPIs were not statistically associated with increased risk of pneumonia among patients concomitantly taking nonsteroidal anti-inflammatory drugs (OR, 1.11; 95% CI, 0.94–1.31; <i>I</i><sup>2</sup>, 5.8%). The funnel plot demonstrated significant publication bias, especially for observational studies. <b>Conclusions</b>: The presence of significant between-study heterogeneity and publication bias raised concerns regarding the validity of the primary meta-analytic result. Protopathic bias, or reverse causality, may cause overestimated association. Studies that adopted a design to account for protopathic bias did not show a significant association between PPI use and risk of pneumonia.
DOI: 10.7284/109901
title: GNSS (Global Navigation Satellite System) data collected during research cruise AE1201 using a Furuno GP-90 instrument system onboard the platform RV Atlantic Explorer

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/111602
title: CTD (Conductivity, Temperature, Depth) data collected during research cruise AE1202 using a Sea-Bird SBE-911+ instrument system onboard the platform RV Atlantic Explorer

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7757048
title: 2D- and 3D-QSAR modelling, molecular docking and <i>in vitro</i> evaluation studies on 18β-glycyrrhetinic acid derivatives against triple-negative breast cancer cell line

description: Triple-negative breast cancers (TNBCs) are one of the most aggressive and complex forms of cancers in women. TNBCs are commonly known for their complex heterogeneity and poor prognosis. The present work aimed to develop a predictive 2D and 3D quantitative structure–activity relationship (QSAR) models against metastatic TNBC cell line. The 2D-QSAR was based on multiple linear regression analysis and validated by Leave-One-Out (LOO) and external test set prediction approach. QSAR model presented regression coefficient values for training set (<i>r</i><sup>2</sup>), LOO-based internal regression (<i>q</i><sup>2</sup>) and external test set regression (pred_<i>r</i><sup>2</sup>) which are 0.84, 0.82 and 0.75, respectively. Five properties, Epsilon4 (electronegativity), ChiV3cluster (valence molecular connectivity index), chi3chain (retention index for three-membered ring), TNN5 (nitrogen atoms separated through 5 bond distance) and nitrogen counts, were identified as important structural features responsible for anticancer activity of MDA-MB-231 inhibitors. Five novel derivatives of glycyrrhetinic acid (GA) named GA-1, GA-2, GA-3, GA-4 and GA-5 were semi-synthesised and screened through the QSAR model. Further, <i>in vitro</i> activities of the derivatives were analysed against human TNBC cell line, MDA-MB-231. The result showed that GA-1 exhibits improved cytotoxic activity to that of parent compound (GA). Further, atomic property field (APF)-based 3D-QSAR and scoring recognise C-30 carboxylic group of GA-1 as major influential factor for its anticancer activity. The significance of C-30 carboxylic group in GA derivatives was also confirmed by molecular docking study against cancer target glyoxalase-I. Finally, the oral bioavailability and toxicity of GA-1 were assessed by computational ADMET studies. Communicated by Ramaswamy H. Sarma
DOI: 10.6084/m9.figshare.7757051
title: A Bayesian approach for misclassified ordinal response data

description: Motivated by a longitudinal oral health study, the Signal-Tandmobiel<sup>®</sup> study, a Bayesian approach has been developed to model misclassified ordinal response data. Two regression models have been considered to incorporate misclassification in the categorical response. Specifically, probit and logit models have been developed. The computational difficulties have been avoided by using data augmentation. This idea is exploited to derive efficient Markov chain Monte Carlo methods. Although the method is proposed for ordered categories, it can also be implemented for unordered ones in a simple way. The model performance is shown through a simulation-based example and the analysis of the motivating study.
DOI: 10.7284/109902
title: GNSS (Global Navigation Satellite System) data collected during research cruise AE1202 using a Furuno GP-90 instrument system onboard the platform RV Atlantic Explorer

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7757045
title: A numerical investigation of influence of low-plasticity fines in sand on lateral response of piles

description: Experimental evidence suggests that sands containing non-plastic or low-plasticity fines may show either decreasing or increasing shear strength with increasing fines content in certain situations. Accordingly, the presence of low-plasticity fines can significantly affect the ultimate lateral soil resistance; thus low-plasticity fines can affect the lateral response of piles. In this study, a quantitative method is proposed for determining the effect of low-plasticity fines in sand on the lateral response of piles in sand by combining a strain wedge model and a unified critical state compatible (UCSC) framework. An equivalent granular state parameter is employed in the UCSC framework to define the soil state uniquely in the strain wedge. The proposed quantitative method is incorporated in a finite element program. A series of numerical analyses are performed on a laterally loaded pile embedded in various relative densities of the base (clean) sand, to which various quantities of low-plasticity fines are added. The effect of low-plasticity fines on the lateral response is investigated. Furthermore, the effect of the low-plasticity fines on the response of the strain wedge is discussed.
DOI: 10.6084/m9.figshare.7757051.v1
title: A Bayesian approach for misclassified ordinal response data

description: Motivated by a longitudinal oral health study, the Signal-Tandmobiel<sup>®</sup> study, a Bayesian approach has been developed to model misclassified ordinal response data. Two regression models have been considered to incorporate misclassification in the categorical response. Specifically, probit and logit models have been developed. The computational difficulties have been avoided by using data augmentation. This idea is exploited to derive efficient Markov chain Monte Carlo methods. Although the method is proposed for ordered categories, it can also be implemented for unordered ones in a simple way. The model performance is shown through a simulation-based example and the analysis of the motivating study.
DOI: 10.7284/109903
title: GNSS (Global Navigation Satellite System) data collected during research cruise AE1203 using a Furuno GP-90 instrument system onboard the platform RV Atlantic Explorer

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7757045.v2
title: A numerical investigation of influence of low-plasticity fines in sand on lateral response of piles

description: Experimental evidence suggests that sands containing non-plastic or low-plasticity fines may show either decreasing or increasing shear strength with increasing fines content in certain situations. Accordingly, the presence of low-plasticity fines can significantly affect the ultimate lateral soil resistance; thus low-plasticity fines can affect the lateral response of piles. In this study, a quantitative method is proposed for determining the effect of low-plasticity fines in sand on the lateral response of piles in sand by combining a strain wedge model and a unified critical state compatible (UCSC) framework. An equivalent granular state parameter is employed in the UCSC framework to define the soil state uniquely in the strain wedge. The proposed quantitative method is incorporated in a finite element program. A series of numerical analyses are performed on a laterally loaded pile embedded in various relative densities of the base (clean) sand, to which various quantities of low-plasticity fines are added. The effect of low-plasticity fines on the lateral response is investigated. Furthermore, the effect of the low-plasticity fines on the response of the strain wedge is discussed.
DOI: 10.6084/m9.figshare.7757048.v1
title: 2D- and 3D-QSAR modelling, molecular docking and <i>in vitro</i> evaluation studies on 18β-glycyrrhetinic acid derivatives against triple-negative breast cancer cell line

description: Triple-negative breast cancers (TNBCs) are one of the most aggressive and complex forms of cancers in women. TNBCs are commonly known for their complex heterogeneity and poor prognosis. The present work aimed to develop a predictive 2D and 3D quantitative structure–activity relationship (QSAR) models against metastatic TNBC cell line. The 2D-QSAR was based on multiple linear regression analysis and validated by Leave-One-Out (LOO) and external test set prediction approach. QSAR model presented regression coefficient values for training set (<i>r</i><sup>2</sup>), LOO-based internal regression (<i>q</i><sup>2</sup>) and external test set regression (pred_<i>r</i><sup>2</sup>) which are 0.84, 0.82 and 0.75, respectively. Five properties, Epsilon4 (electronegativity), ChiV3cluster (valence molecular connectivity index), chi3chain (retention index for three-membered ring), TNN5 (nitrogen atoms separated through 5 bond distance) and nitrogen counts, were identified as important structural features responsible for anticancer activity of MDA-MB-231 inhibitors. Five novel derivatives of glycyrrhetinic acid (GA) named GA-1, GA-2, GA-3, GA-4 and GA-5 were semi-synthesised and screened through the QSAR model. Further, <i>in vitro</i> activities of the derivatives were analysed against human TNBC cell line, MDA-MB-231. The result showed that GA-1 exhibits improved cytotoxic activity to that of parent compound (GA). Further, atomic property field (APF)-based 3D-QSAR and scoring recognise C-30 carboxylic group of GA-1 as major influential factor for its anticancer activity. The significance of C-30 carboxylic group in GA derivatives was also confirmed by molecular docking study against cancer target glyoxalase-I. Finally, the oral bioavailability and toxicity of GA-1 were assessed by computational ADMET studies. Communicated by Ramaswamy H. Sarma
DOI: 10.7284/111600
title: CTD (Conductivity, Temperature, Depth) data collected during research cruise AE1204 using a Sea-Bird SBE-911+ instrument system onboard the platform RV Atlantic Explorer

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7757048.v2
title: 2D- and 3D-QSAR modelling, molecular docking and <i>in vitro</i> evaluation studies on 18β-glycyrrhetinic acid derivatives against triple-negative breast cancer cell line

description: Triple-negative breast cancers (TNBCs) are one of the most aggressive and complex forms of cancers in women. TNBCs are commonly known for their complex heterogeneity and poor prognosis. The present work aimed to develop a predictive 2D and 3D quantitative structure–activity relationship (QSAR) models against metastatic TNBC cell line. The 2D-QSAR was based on multiple linear regression analysis and validated by Leave-One-Out (LOO) and external test set prediction approach. QSAR model presented regression coefficient values for training set (<i>r</i><sup>2</sup>), LOO-based internal regression (<i>q</i><sup>2</sup>) and external test set regression (pred_<i>r</i><sup>2</sup>) which are 0.84, 0.82 and 0.75, respectively. Five properties, Epsilon4 (electronegativity), ChiV3cluster (valence molecular connectivity index), chi3chain (retention index for three-membered ring), TNN5 (nitrogen atoms separated through 5 bond distance) and nitrogen counts, were identified as important structural features responsible for anticancer activity of MDA-MB-231 inhibitors. Five novel derivatives of glycyrrhetinic acid (GA) named GA-1, GA-2, GA-3, GA-4 and GA-5 were semi-synthesised and screened through the QSAR model. Further, <i>in vitro</i> activities of the derivatives were analysed against human TNBC cell line, MDA-MB-231. The result showed that GA-1 exhibits improved cytotoxic activity to that of parent compound (GA). Further, atomic property field (APF)-based 3D-QSAR and scoring recognise C-30 carboxylic group of GA-1 as major influential factor for its anticancer activity. The significance of C-30 carboxylic group in GA derivatives was also confirmed by molecular docking study against cancer target glyoxalase-I. Finally, the oral bioavailability and toxicity of GA-1 were assessed by computational ADMET studies. Communicated by Ramaswamy H. Sarma
DOI: 10.6084/m9.figshare.7757048.v4
title: 2D- and 3D-QSAR modelling, molecular docking and <i>in vitro</i> evaluation studies on 18β-glycyrrhetinic acid derivatives against triple-negative breast cancer cell line

description: Triple-negative breast cancers (TNBCs) are one of the most aggressive and complex forms of cancers in women. TNBCs are commonly known for their complex heterogeneity and poor prognosis. The present work aimed to develop a predictive 2D and 3D quantitative structure–activity relationship (QSAR) models against metastatic TNBC cell line. The 2D-QSAR was based on multiple linear regression analysis and validated by Leave-One-Out (LOO) and external test set prediction approach. QSAR model presented regression coefficient values for training set (<i>r</i><sup>2</sup>), LOO-based internal regression (<i>q</i><sup>2</sup>) and external test set regression (pred_<i>r</i><sup>2</sup>) which are 0.84, 0.82 and 0.75, respectively. Five properties, Epsilon4 (electronegativity), ChiV3cluster (valence molecular connectivity index), chi3chain (retention index for three-membered ring), TNN5 (nitrogen atoms separated through 5 bond distance) and nitrogen counts, were identified as important structural features responsible for anticancer activity of MDA-MB-231 inhibitors. Five novel derivatives of glycyrrhetinic acid (GA) named GA-1, GA-2, GA-3, GA-4 and GA-5 were semi-synthesised and screened through the QSAR model. Further, <i>in vitro</i> activities of the derivatives were analysed against human TNBC cell line, MDA-MB-231. The result showed that GA-1 exhibits improved cytotoxic activity to that of parent compound (GA). Further, atomic property field (APF)-based 3D-QSAR and scoring recognise C-30 carboxylic group of GA-1 as major influential factor for its anticancer activity. The significance of C-30 carboxylic group in GA derivatives was also confirmed by molecular docking study against cancer target glyoxalase-I. Finally, the oral bioavailability and toxicity of GA-1 were assessed by computational ADMET studies. Communicated by Ramaswamy H. Sarma
DOI: 10.7284/109904
title: GNSS (Global Navigation Satellite System) data collected during research cruise AE1204 using a Furuno GP-90 instrument system onboard the platform RV Atlantic Explorer

description: Original (unprocessed) data collected during a Field_expedition