cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.21213173
title: ENDLESSLY READING: A BRIEF FORAY INTO READING STRATEGIES IN THE CLASSROOM

description: ABSTRACT: In this article, we start from the report of three experiences lived in IFPE Campus Recife to think about the teaching of literature in the integrated secondary school system. Our objective with this work is to discuss how the teaching of literature can stimulate the construction of knowledge in a perspective that calls the student, as a historical subject, to the encounter with (and by) language, mainly based on the thought of Candido (1988), Freire (1989) e Manguel (1997). We can highlight some issues that were central to our experiences: the importance of making room for the voices that populate the classroom; the urgency of the dynamics between language and reality, in the confrontation and in the encounters of the work of art with the lived life; and the valorization of authorship and multiple reading strategies as possible responses to problems such as apathy, curricular obstacles and time.
DOI: 10.6084/m9.figshare.21213173.v1
title: ENDLESSLY READING: A BRIEF FORAY INTO READING STRATEGIES IN THE CLASSROOM

description: ABSTRACT: In this article, we start from the report of three experiences lived in IFPE Campus Recife to think about the teaching of literature in the integrated secondary school system. Our objective with this work is to discuss how the teaching of literature can stimulate the construction of knowledge in a perspective that calls the student, as a historical subject, to the encounter with (and by) language, mainly based on the thought of Candido (1988), Freire (1989) e Manguel (1997). We can highlight some issues that were central to our experiences: the importance of making room for the voices that populate the classroom; the urgency of the dynamics between language and reality, in the confrontation and in the encounters of the work of art with the lived life; and the valorization of authorship and multiple reading strategies as possible responses to problems such as apathy, curricular obstacles and time.
DOI: 10.6084/m9.figshare.21213176
title: Influence of Luminosity on Functional Attributes in Quesnelia quesneliana (Brongn.) L.B.Sm.

description: ABSTRACT Quesnelia quesneliana is an endemic species from Brazil with restricted distribution in restinga areas and has been suffering from changes in its habitat. This study aimed to evaluate the influence of light on the morpho-anatomy and pigment content of Q. quesneliana. The samples were collected in the Liberdade neighborhood in São Mateus, Espírito Santo State, Brazil, which is impacted by anthropization. The influence of light was tested comparing individuals completely exposed to it and individuals under shade. For a morphobiometric analysis, 150 individuals were measured for each light condition, and for pigment determination, 10 leaves were used for each light condition. For anatomical analysis, samples were fixed in 50% FAA and transferred to 70 % ethanol solution after 48 hours. Cross sections were made on roots and stems, and transverse and paradermal sections on leaves. It was concluded that individuals exposed to light are smaller, with higher carotenoid content, while shaded individuals are larger, with more succulent and darker leaves due to greater accumulation of chlorophyll. Anatomically, the individual’s structure is similar.
DOI: 10.6084/m9.figshare.21213176.v1
title: Influence of Luminosity on Functional Attributes in Quesnelia quesneliana (Brongn.) L.B.Sm.

description: ABSTRACT Quesnelia quesneliana is an endemic species from Brazil with restricted distribution in restinga areas and has been suffering from changes in its habitat. This study aimed to evaluate the influence of light on the morpho-anatomy and pigment content of Q. quesneliana. The samples were collected in the Liberdade neighborhood in São Mateus, Espírito Santo State, Brazil, which is impacted by anthropization. The influence of light was tested comparing individuals completely exposed to it and individuals under shade. For a morphobiometric analysis, 150 individuals were measured for each light condition, and for pigment determination, 10 leaves were used for each light condition. For anatomical analysis, samples were fixed in 50% FAA and transferred to 70 % ethanol solution after 48 hours. Cross sections were made on roots and stems, and transverse and paradermal sections on leaves. It was concluded that individuals exposed to light are smaller, with higher carotenoid content, while shaded individuals are larger, with more succulent and darker leaves due to greater accumulation of chlorophyll. Anatomically, the individual’s structure is similar.
DOI: 10.6084/m9.figshare.21213177
title: Adenine phosphoribosyl transferase deficiency leads to renal allograft dysfunction in kidney transplant recipients: a systematic review

description: Abstract Background: Adenine phosphoribosyl transferase (APRT) deficiency has great implications on graft survival in kidney transplant patients. This systematic review investigated the diagnostic pattern, treatment approach, and kidney transplant outcomes among kidney transplant patients with adenine phosphoribosyl transferase deficiency. Material and methods: Articles reporting the APRT enzyme deficiency and kidney allograft dysfunction were retrieved from PubMed/Medline, ScienceDirect, Cochrane library and Google scholar databases. Descriptive analysis was used to draw inferences. Results: The results from 20 selected studies covering 30 patients receiving 39 grafts had an average age of 46.37 years are presented. Graft survival time of more than 6 months was reported in 23 (76.7%) patients, while other 7 (23.3%) patients had graft survival time of less than 6 months. Only 4 (13.3%) patients had APRT deficiency before transplantation. After follow-up, one-third of the patients 10 (33.3%) had stable graft function, 1 patient had allograft loss, 8 (26.6%) patients had delayed graft function while the remaining 11 (36.6%) patients had chronic kidney graft dysfunction. Conclusions: APRT deficiency is an under-recognized, treatable condition that causes reversible crystalline nephropathy, leading to loss of allograft or allograft dysfunction. The study results showed that inclusion of genetic determination of APRT deficiency in the differential diagnosis of crystalline nephropathy, even in the absence of a history of nephrolithiasis, can improve renal outcomes and may improve allograft survival.
DOI: 10.6084/m9.figshare.21213177.v1
title: Adenine phosphoribosyl transferase deficiency leads to renal allograft dysfunction in kidney transplant recipients: a systematic review

description: Abstract Background: Adenine phosphoribosyl transferase (APRT) deficiency has great implications on graft survival in kidney transplant patients. This systematic review investigated the diagnostic pattern, treatment approach, and kidney transplant outcomes among kidney transplant patients with adenine phosphoribosyl transferase deficiency. Material and methods: Articles reporting the APRT enzyme deficiency and kidney allograft dysfunction were retrieved from PubMed/Medline, ScienceDirect, Cochrane library and Google scholar databases. Descriptive analysis was used to draw inferences. Results: The results from 20 selected studies covering 30 patients receiving 39 grafts had an average age of 46.37 years are presented. Graft survival time of more than 6 months was reported in 23 (76.7%) patients, while other 7 (23.3%) patients had graft survival time of less than 6 months. Only 4 (13.3%) patients had APRT deficiency before transplantation. After follow-up, one-third of the patients 10 (33.3%) had stable graft function, 1 patient had allograft loss, 8 (26.6%) patients had delayed graft function while the remaining 11 (36.6%) patients had chronic kidney graft dysfunction. Conclusions: APRT deficiency is an under-recognized, treatable condition that causes reversible crystalline nephropathy, leading to loss of allograft or allograft dysfunction. The study results showed that inclusion of genetic determination of APRT deficiency in the differential diagnosis of crystalline nephropathy, even in the absence of a history of nephrolithiasis, can improve renal outcomes and may improve allograft survival.
DOI: 10.5281/zenodo.6796904
title: Petruk et al raw data

description: This file contains raw numeric data related to our manuscript submitted to Cancer Biology and Therapy, July 2022
DOI: 10.5281/zenodo.7115338
title: Petruk et al raw data

description: This file contains raw numeric data related to our manuscript submitted to Cancer Biology and Therapy, July 2022
DOI: 10.5281/zenodo.6796903
title: Petruk et al raw data

description: This file contains raw numeric data related to our manuscript submitted to Cancer Biology and Therapy, July 2022
DOI: 10.6084/m9.figshare.21213131
title: Lab data Yun Chen

description: These data belonged to AG Röszer, University of Ulm in Germany. They serve as backup and records.
DOI: 10.6084/m9.figshare.21213131.v1
title: Lab data Yun Chen

description: These data belonged to AG Röszer, University of Ulm in Germany. They serve as backup and records.
DOI: 10.6084/m9.figshare.21213180
title: Cross-sectional assessment of mild cognitive impairment in pre-dialysis chronic kidney disease and its association with inflammation and changes seen on MRI: what the eyes cannot see

description: Abstract Introduction: Mild cognitive impairment (MCI) is a prevalent and underdiagnosed condition in chronic kidney disease (CKD), that shares common pathophysiological factors such as chronic inflammation. Objective: To evaluate the association of MCI in CKD stages 1-5 using inflammatory markers and changes by magnetic resonance imaging (MRI). Patients and Methods: Cross-sectional study in adult patients with pre-dialysis CKD. MCI was assessed by the Montreal Cognitive Assessment (MoCA) and the estimated glomerular filtration rate (eGFR) by the Chronic Kidney Disease Epidemiology Collaboration equation. Sociodemographic and clinical data were collected from medical records. The cytokines IL-4, IL-6, IL-17, TNF-α and hs-CRP were determined. Brain MRI was performed in a 1.5 Tesla device, without paramagnetic contrast. A descriptive analysis followed by a comparison of abnormal versus normal MoCA scores among all studied variables. A linear regression analysis was performed using MoCA as a dependent variable, adjusted for confounding factors. Results: Of 111 invited patients, eighty completed the neuropsychological assessment and 56 underwent MRI, and were included in the study. Mean age was 56.3 ± 8.3 years and 51.8% (n = 29) had altered MoCA. When compared to the group with normal MoCA, the group with altered MoCA had higher levels of IL-6 and IL-17. There was no correlation between altered MoCA with eGFR or with MRI abnormalities. Conclusão: MCI assessed by MoCA was prevalent in patients with pre-dialysis CKD, it was associated with inflammation and showed no correlation with MRI changes.
DOI: 10.6084/m9.figshare.21213180.v1
title: Cross-sectional assessment of mild cognitive impairment in pre-dialysis chronic kidney disease and its association with inflammation and changes seen on MRI: what the eyes cannot see

description: Abstract Introduction: Mild cognitive impairment (MCI) is a prevalent and underdiagnosed condition in chronic kidney disease (CKD), that shares common pathophysiological factors such as chronic inflammation. Objective: To evaluate the association of MCI in CKD stages 1-5 using inflammatory markers and changes by magnetic resonance imaging (MRI). Patients and Methods: Cross-sectional study in adult patients with pre-dialysis CKD. MCI was assessed by the Montreal Cognitive Assessment (MoCA) and the estimated glomerular filtration rate (eGFR) by the Chronic Kidney Disease Epidemiology Collaboration equation. Sociodemographic and clinical data were collected from medical records. The cytokines IL-4, IL-6, IL-17, TNF-α and hs-CRP were determined. Brain MRI was performed in a 1.5 Tesla device, without paramagnetic contrast. A descriptive analysis followed by a comparison of abnormal versus normal MoCA scores among all studied variables. A linear regression analysis was performed using MoCA as a dependent variable, adjusted for confounding factors. Results: Of 111 invited patients, eighty completed the neuropsychological assessment and 56 underwent MRI, and were included in the study. Mean age was 56.3 ± 8.3 years and 51.8% (n = 29) had altered MoCA. When compared to the group with normal MoCA, the group with altered MoCA had higher levels of IL-6 and IL-17. There was no correlation between altered MoCA with eGFR or with MRI abnormalities. Conclusão: MCI assessed by MoCA was prevalent in patients with pre-dialysis CKD, it was associated with inflammation and showed no correlation with MRI changes.
DOI: 10.6084/m9.figshare.21213182
title: Educational technology for infants’ families to identify warning signs: a validation study

description: ABSTRACT Objective: To validate, with the target audience, the usability and appearance of a serialized album about the warning signs to the health of children below 2 months. Method: Methodological validation study with the target population of an educational material in the form of a serialized album. 11 mothers with children under 2 months of age participated. The domains evaluated were: Objectives, Organization, Writing Style, Appearance, and Motivation. Data were analyzed using descriptive and statistics, and the data agreement index was calculated. Results: The global data agreement index was high (0.99). Mothers had positive responses, recognizing the excellence of the material: attractive figures that were easy to understand. Conclusion: The validation of the serialized album provides mothers with the abilities and knowledge they need to identify warning signs in regard to the health of their children, providing them with autonomy, corresponsibility, and helping them develop better child health practices.
DOI: 10.6084/m9.figshare.21213182.v1
title: Educational technology for infants’ families to identify warning signs: a validation study

description: ABSTRACT Objective: To validate, with the target audience, the usability and appearance of a serialized album about the warning signs to the health of children below 2 months. Method: Methodological validation study with the target population of an educational material in the form of a serialized album. 11 mothers with children under 2 months of age participated. The domains evaluated were: Objectives, Organization, Writing Style, Appearance, and Motivation. Data were analyzed using descriptive and statistics, and the data agreement index was calculated. Results: The global data agreement index was high (0.99). Mothers had positive responses, recognizing the excellence of the material: attractive figures that were easy to understand. Conclusion: The validation of the serialized album provides mothers with the abilities and knowledge they need to identify warning signs in regard to the health of their children, providing them with autonomy, corresponsibility, and helping them develop better child health practices.
DOI: 10.6084/m9.figshare.21213183
title: Self-injurious behavior and factors related to suicidal intent among adolescents: a documentary study

description: Abstract It is a type of quantitative documentary research of descriptive and exploratory content in which studied the profile of adolescents with self-injurious behavior and the variables of risk and protection regarding the suicidal intent, reported in a Children and Youth Psychosocial Care Center (CAPS IJ) from a metropolitan region in the south of Brazil. Data from 139 assisted adolescents, admitted for self-injury, reported that self-injuries occurred predominantly at home (M=14,36 years; SD=1,63), with multiple episodes, using sharp objects with suicidal intent. The hierarchical binary logistic regression results point out that experiencing abuse in the present -using non-sharps objects- having severe injuries and practicing them in different places are risk variables. Whereas the existence of community and school social support networks are protective factors. There is a necessity of investment in the studies that explore the etiology of self-injuries and that provide support for cases of prevention, detection, and treatment.
DOI: 10.6084/m9.figshare.21213183.v1
title: Self-injurious behavior and factors related to suicidal intent among adolescents: a documentary study

description: Abstract It is a type of quantitative documentary research of descriptive and exploratory content in which studied the profile of adolescents with self-injurious behavior and the variables of risk and protection regarding the suicidal intent, reported in a Children and Youth Psychosocial Care Center (CAPS IJ) from a metropolitan region in the south of Brazil. Data from 139 assisted adolescents, admitted for self-injury, reported that self-injuries occurred predominantly at home (M=14,36 years; SD=1,63), with multiple episodes, using sharp objects with suicidal intent. The hierarchical binary logistic regression results point out that experiencing abuse in the present -using non-sharps objects- having severe injuries and practicing them in different places are risk variables. Whereas the existence of community and school social support networks are protective factors. There is a necessity of investment in the studies that explore the etiology of self-injuries and that provide support for cases of prevention, detection, and treatment.
DOI: 10.6084/m9.figshare.21213185
title: Predictive ability of severity scores and outcomes for mortality in kidney transplant recipients with coronavirus disease 2019 admitted to the intensive care unit: results from a Brazilian single-center cohort study

description: Abstract Background: the predictive ability of severity scores for mortality in patients admitted to intensive care units is not well-known among kidney transplanted (KT) patients, especially those diagnosed with coronavirus disease 2019 (COVID-19). The purpose of the present study was to evaluate the predictive ability of severity scores for mortality in KT recipients. Methods: 51 KT recipients with COVID-19 diagnosis were enrolled. The performance of the SOFA, SAPS 3, and APACHE IV tools in predicting mortality after COVID-19 was compared by the area under the ROC curve (AUC-ROC) and univariate Cox regression analysis was performed. Results: The 90-day cumulative incidence of death was 63.4%. Only APACHE IV score differed between survivors and nonsurvivors: 91.2±18.3 vs. 106.5±26.3, P = 0.03. The AUC- ROC of APACHE IV for predicting death was 0.706 (P = 0.04) and 0.656 (P = 0.06) at 7 and 90 days, respectively. Receiving a kidney from a deceased donor (HR = 3.16; P = 0.03), troponin levels at admission (HR for each ng/mL = 1.001; P = 0.03), APACHE IV score (HR for each 1 point = 1.02; P = 0.01), mechanical ventilation (MV) requirement (HR = 3.04; P = 0.002) and vasopressor use on the first day after ICU admission (HR = 3.85; P &lt; 0.001) were associated with the 90-day mortality in the univariate analysis. Conclusion: KT recipients had high mortality, which was associated with type of donor, troponin levels, early use of vasopressors, and MV requirement. The other traditional severity scores investigated could not predict mortality.
DOI: 10.6084/m9.figshare.21213185.v1
title: Predictive ability of severity scores and outcomes for mortality in kidney transplant recipients with coronavirus disease 2019 admitted to the intensive care unit: results from a Brazilian single-center cohort study

description: Abstract Background: the predictive ability of severity scores for mortality in patients admitted to intensive care units is not well-known among kidney transplanted (KT) patients, especially those diagnosed with coronavirus disease 2019 (COVID-19). The purpose of the present study was to evaluate the predictive ability of severity scores for mortality in KT recipients. Methods: 51 KT recipients with COVID-19 diagnosis were enrolled. The performance of the SOFA, SAPS 3, and APACHE IV tools in predicting mortality after COVID-19 was compared by the area under the ROC curve (AUC-ROC) and univariate Cox regression analysis was performed. Results: The 90-day cumulative incidence of death was 63.4%. Only APACHE IV score differed between survivors and nonsurvivors: 91.2±18.3 vs. 106.5±26.3, P = 0.03. The AUC- ROC of APACHE IV for predicting death was 0.706 (P = 0.04) and 0.656 (P = 0.06) at 7 and 90 days, respectively. Receiving a kidney from a deceased donor (HR = 3.16; P = 0.03), troponin levels at admission (HR for each ng/mL = 1.001; P = 0.03), APACHE IV score (HR for each 1 point = 1.02; P = 0.01), mechanical ventilation (MV) requirement (HR = 3.04; P = 0.002) and vasopressor use on the first day after ICU admission (HR = 3.85; P &lt; 0.001) were associated with the 90-day mortality in the univariate analysis. Conclusion: KT recipients had high mortality, which was associated with type of donor, troponin levels, early use of vasopressors, and MV requirement. The other traditional severity scores investigated could not predict mortality.
DOI: 10.6084/m9.figshare.21213188
title: Characterization of insect-specific Culex flavivirus (Flaviviridae) nucleotide sequences in mosquitoes from urban parks in São Paulo, Brazil

description: ABSTRACT Background: Despite their worldwide occurrence, the distribution and role of insect-specific flaviviruses (ISFs) remain unclear. Methods: We evaluated the presence of ISFs in mosquitoes collected in São Paulo, Brazil, using reverse transcription and semi-nested polymerase chain reaction (PCR). Some of the positive samples were subjected to nanopore sequencing. Results: Twelve mosquito pools (2.8%) tested positive for flavivirus infection. Nanopore sequencing was successfully performed on six samples. Phylogenetic analysis grouped these sequences into genotype 2 of Culex flavivirus (CxFV). Conclusions: The identification of CxFV genotype 2 at new locations in São Paulo highlights the importance of understanding the role of ISFs in mosquito vector competence.
DOI: 10.6084/m9.figshare.21213188.v1
title: Characterization of insect-specific Culex flavivirus (Flaviviridae) nucleotide sequences in mosquitoes from urban parks in São Paulo, Brazil

description: ABSTRACT Background: Despite their worldwide occurrence, the distribution and role of insect-specific flaviviruses (ISFs) remain unclear. Methods: We evaluated the presence of ISFs in mosquitoes collected in São Paulo, Brazil, using reverse transcription and semi-nested polymerase chain reaction (PCR). Some of the positive samples were subjected to nanopore sequencing. Results: Twelve mosquito pools (2.8%) tested positive for flavivirus infection. Nanopore sequencing was successfully performed on six samples. Phylogenetic analysis grouped these sequences into genotype 2 of Culex flavivirus (CxFV). Conclusions: The identification of CxFV genotype 2 at new locations in São Paulo highlights the importance of understanding the role of ISFs in mosquito vector competence.