cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.7195457
title: Supplementary Material for: Patient Preference and Physician Perceptions of Patient Preference for Oral Pharmaceutical Formulations: Results from a Real-Life Survey

description: <b><i>Background:</i></b> Pharmaceutical treatment prescribed according to patient preference for a formulation may have a positive impact on adherence to treatment and consequently on treatment outcomes. <b><i>Aim:</i></b> This study aimed at understanding patient preference for pharmaceutical formulations and attributes that trigger patient preference and physician perception of patient preference. <b><i>Methods:</i></b> Between August and September 2017, gastroenterologists and patients with mild to moderate ulcerative colitis from France, Germany, Spain, and the UK participated in an online survey. The investigation was exploratory in nature, and descriptive results are presented. <b><i>Results:</i></b> Patient (<i>n</i> = 380) preference appears to be driven by the appearance (format, shape, size, and color – 44%), number of units per administration (39%), and number of administrations per day (17%). Gastroenterologist (<i>n</i> = 159) preference is instead driven by the number of administrations per day (55%), number of units per day (26%), and tablet size (19%). Overall, 254 (67%) patients preferred a tablet formulation, 111 (29%) preferred granules, and 15 (4%) other formulations. According to gastroenterologist perception of patient preference, only 49% of patients prefer tablets, 38% prefer granules, and 13% have no preference. After switching from granules to tablets, 25% patients expressed negative feelings for granules. However, after switching from tablets to granules, 44% of patients still have positive perceptions of tablets. Among patients receiving tablets (<i>n</i> = 255), 18 (7%) perceived their treatment to be not at all effective versus 16 (13%) patients receiving granules (<i>n</i> = 125). A similar proportion of patients in the two groups perceived their treatment as extremely effective (48 vs. 46%, respectively). <b><i>Conclusions:</i></b> Patients generally prefer tablets. Patient and gastroenterologist perception of patient preference for different oral drug formulations is triggered by the same attributes but with inverse importance. To improve adherence, patients should be involved in the choice of the treatment formulation.
DOI: 10.6084/m9.figshare.7195505.v1
title: Supplementary Material for: Activation Levels, Cardiovascular Risk, and Functional Impairment in Remitted Bipolar Patients: Clinical Relevance of a Dimensional Approach

description: Medicine
DOI: 10.7284/134404
title: Meteorological Station data collected during research cruise SR1912 using a SIO MET-System instrument system onboard the platform RV Sally Ride

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7195454
title: Mercury-induced motor and sensory neurotoxicity: systematic review of workers currently exposed to mercury vapor

description: The neurotoxicity of elemental mercury (Hg<sup>0</sup>) is well-recognized, but it is uncertain whether and for how long neurotoxicity persists; among studies that evaluated <i>previously exposed</i> workers, only one examined workers during and also years after exposure ceased. The aim of this review is to document the type, frequency, and dose-relatedness of objective neurological effects in <i>currently exposed</i> mercury workers and thereby provide first approximations of the effects one would have expected in <i>previously exposed</i> workers evaluated during exposure. We systematically reviewed studies of neurotoxicity in <i>currently exposed</i> mercury workers identified by searching MEDLINE (1950–2015), government reports, textbook chapters, and references cited therein; dental cohorts were not included. Outcomes on physical examination (PE), neurobehavioral (NB) tests, and electrophysiological studies were extracted and evaluated for consistency and dose-relatedness. Forty-five eligible studies were identified, comprising over 3000 workers chronically exposed to a range of Hg<sup>0</sup> concentrations (0.002–1.7 mg/m<sup>3</sup>). Effects that demonstrated consistency across studies and increased frequency across urine mercury levels (&lt;50; 50–99; 100–199; ≥200 μg/L) included tremor, impaired coordination, and abnormal reflexes on PE, and reduced performance on NB tests of tremor, manual dexterity and motor speed. The data suggest response thresholds of U<sub>Hg</sub> ≈275 μg/L for PE findings and ≈20 μg/L for NB outcomes. These results indicate that PE is of particular value for assessing workers with U<sub>Hg</sub> &gt;200 μg/L, while NB testing is more appropriate for those with lower U<sub>Hg</sub> levels. They also provide benchmarks to which findings in workers with historical exposure can be compared.
DOI: 10.6084/m9.figshare.7195457.v1
title: Supplementary Material for: Patient Preference and Physician Perceptions of Patient Preference for Oral Pharmaceutical Formulations: Results from a Real-Life Survey

description: <b><i>Background:</i></b> Pharmaceutical treatment prescribed according to patient preference for a formulation may have a positive impact on adherence to treatment and consequently on treatment outcomes. <b><i>Aim:</i></b> This study aimed at understanding patient preference for pharmaceutical formulations and attributes that trigger patient preference and physician perception of patient preference. <b><i>Methods:</i></b> Between August and September 2017, gastroenterologists and patients with mild to moderate ulcerative colitis from France, Germany, Spain, and the UK participated in an online survey. The investigation was exploratory in nature, and descriptive results are presented. <b><i>Results:</i></b> Patient (<i>n</i> = 380) preference appears to be driven by the appearance (format, shape, size, and color – 44%), number of units per administration (39%), and number of administrations per day (17%). Gastroenterologist (<i>n</i> = 159) preference is instead driven by the number of administrations per day (55%), number of units per day (26%), and tablet size (19%). Overall, 254 (67%) patients preferred a tablet formulation, 111 (29%) preferred granules, and 15 (4%) other formulations. According to gastroenterologist perception of patient preference, only 49% of patients prefer tablets, 38% prefer granules, and 13% have no preference. After switching from granules to tablets, 25% patients expressed negative feelings for granules. However, after switching from tablets to granules, 44% of patients still have positive perceptions of tablets. Among patients receiving tablets (<i>n</i> = 255), 18 (7%) perceived their treatment to be not at all effective versus 16 (13%) patients receiving granules (<i>n</i> = 125). A similar proportion of patients in the two groups perceived their treatment as extremely effective (48 vs. 46%, respectively). <b><i>Conclusions:</i></b> Patients generally prefer tablets. Patient and gastroenterologist perception of patient preference for different oral drug formulations is triggered by the same attributes but with inverse importance. To improve adherence, patients should be involved in the choice of the treatment formulation.
DOI: 10.6084/m9.figshare.7195454.v1
title: Mercury-induced motor and sensory neurotoxicity: systematic review of workers currently exposed to mercury vapor

description: The neurotoxicity of elemental mercury (Hg<sup>0</sup>) is well-recognized, but it is uncertain whether and for how long neurotoxicity persists; among studies that evaluated <i>previously exposed</i> workers, only one examined workers during and also years after exposure ceased. The aim of this review is to document the type, frequency, and dose-relatedness of objective neurological effects in <i>currently exposed</i> mercury workers and thereby provide first approximations of the effects one would have expected in <i>previously exposed</i> workers evaluated during exposure. We systematically reviewed studies of neurotoxicity in <i>currently exposed</i> mercury workers identified by searching MEDLINE (1950–2015), government reports, textbook chapters, and references cited therein; dental cohorts were not included. Outcomes on physical examination (PE), neurobehavioral (NB) tests, and electrophysiological studies were extracted and evaluated for consistency and dose-relatedness. Forty-five eligible studies were identified, comprising over 3000 workers chronically exposed to a range of Hg<sup>0</sup> concentrations (0.002–1.7 mg/m<sup>3</sup>). Effects that demonstrated consistency across studies and increased frequency across urine mercury levels (&lt;50; 50–99; 100–199; ≥200 μg/L) included tremor, impaired coordination, and abnormal reflexes on PE, and reduced performance on NB tests of tremor, manual dexterity and motor speed. The data suggest response thresholds of U<sub>Hg</sub> ≈275 μg/L for PE findings and ≈20 μg/L for NB outcomes. These results indicate that PE is of particular value for assessing workers with U<sub>Hg</sub> &gt;200 μg/L, while NB testing is more appropriate for those with lower U<sub>Hg</sub> levels. They also provide benchmarks to which findings in workers with historical exposure can be compared.
DOI: 10.6084/m9.figshare.7195448
title: Supplementary Material for: Moisturizers versus Current and Next-Generation Barrier Repair Therapy for the Management of Atopic Dermatitis

description: We compare here the principal characteristics of over-the-counter moisturizers with physiologic lipid-based barrier repair therapy. Moisturizers are standard ancillary therapy for anti-inflammatory skin disorders, like atopic dermatitis (AD), and can attenuate the emergence of AD, the initial step in the “atopic march.” But not all moisturizers are beneficial; some can make skin function worse, and can even induce inflammation, possibly accounting for the frequent occurrence of “sensitive skin” in women. In contrast, physiologic lipid-based barrier repair therapy, if comprised of the 3 key stratum corneum lipids, in sufficient quantities and at an appropriate molar ratio, can correct the barrier abnormality and reduce inflammation in AD, and perhaps in other inflammatory dermatoses.
DOI: 10.6084/m9.figshare.7195451
title: Persistence of mercury-induced motor and sensory neurotoxicity: systematic review of workers previously exposed to mercury vapor

description: Elemental mercury (Hg<sup>0</sup>) is a well-recognized neurotoxicant, but it is uncertain whether and for how long its neurotoxicity persists. Among studies that evaluated <i>previously-exposed</i> workers, only one examined workers during and also years after exposure had ceased. The objective of this review is to create a series of ‘synthetic’ longitudinal studies to address the question of persistence of Hg<sup>0</sup> neurotoxicity in occupationally exposed workers. We systematically reviewed studies describing objective motor and sensory effects in <i>previously-exposed</i> mercury workers. Data from physical examination (PE), neurobehavioral (NB) tests, and electrophysiological studies (EPS) were extracted into structured tables and examined for their consistency and dose-relatedness and then compared with the corresponding results from studies of currently exposed workers. We identified six cohorts that described neurological findings in 1299 workers, examined an average of 4.8–30 years after the cessation of exposure. Historical group mean U<sub>Hg</sub> levels ranged from 23 to &gt;500 μg/L, with U<sub>Hg</sub> levels &gt;6000 μg/L in some individuals. Overall, few findings were significant; most were inconsistent across the previous-exposure studies, and in comparisons between studies of previously and currently exposed workers. The results of this systematic review indicate that Hg<sup>0</sup>-related neurotoxic effects detectable on PE, NB testing, and EPS are substantially reversed over time. To the extent that such effects do persist, they are reported principally in workers who have had very high-dose exposures. In addition, based on the limited available data, those effects reported to persist have been described as having little or no functional significance.
DOI: 10.7284/134407
title: Multibeam Echosounder data collected during research cruise SR1912 using a Kongsberg EM122 instrument system onboard the platform RV Sally Ride

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7195451.v1
title: Persistence of mercury-induced motor and sensory neurotoxicity: systematic review of workers previously exposed to mercury vapor

description: Elemental mercury (Hg<sup>0</sup>) is a well-recognized neurotoxicant, but it is uncertain whether and for how long its neurotoxicity persists. Among studies that evaluated <i>previously-exposed</i> workers, only one examined workers during and also years after exposure had ceased. The objective of this review is to create a series of ‘synthetic’ longitudinal studies to address the question of persistence of Hg<sup>0</sup> neurotoxicity in occupationally exposed workers. We systematically reviewed studies describing objective motor and sensory effects in <i>previously-exposed</i> mercury workers. Data from physical examination (PE), neurobehavioral (NB) tests, and electrophysiological studies (EPS) were extracted into structured tables and examined for their consistency and dose-relatedness and then compared with the corresponding results from studies of currently exposed workers. We identified six cohorts that described neurological findings in 1299 workers, examined an average of 4.8–30 years after the cessation of exposure. Historical group mean U<sub>Hg</sub> levels ranged from 23 to &gt;500 μg/L, with U<sub>Hg</sub> levels &gt;6000 μg/L in some individuals. Overall, few findings were significant; most were inconsistent across the previous-exposure studies, and in comparisons between studies of previously and currently exposed workers. The results of this systematic review indicate that Hg<sup>0</sup>-related neurotoxic effects detectable on PE, NB testing, and EPS are substantially reversed over time. To the extent that such effects do persist, they are reported principally in workers who have had very high-dose exposures. In addition, based on the limited available data, those effects reported to persist have been described as having little or no functional significance.
DOI: 10.6084/m9.figshare.7195430
title: A molecular assessment of species diversity and generic boundaries in the red algal tribes Polysiphonieae and Streblocladieae (Rhodomelaceae, Rhodophyta) in Canada

description: Sequence data generated during a Canadian barcode survey (COI-5P) of the tribes Polysiphonieae and Streblocladieae, a large and taxonomically challenging group of red algae, revealed significant taxonomic confusion and hidden species diversity. <i>Polysiphonia pacifica</i> Hollenberg, <i>P. paniculata</i> Montagne, <i>P. stricta</i> (Dillwyn) Greville and <i>Vertebrata fucoides</i> (Hudson) Kuntze were all complexes of two or more genetically distinct yet overlooked species. One variety of <i>P. pacifica</i> was elevated to the rank of species as <i>P. determinata</i> (Hollenberg) Savoie & Saunders, stat. nov. Several new additions to the Canadian flora were recorded including <i>P. kapraunii</i> Stuercke & Freshwater and <i>P. morrowii</i> Harvey. Subsequent multi-gene (COI-5P, LSU and <i>rbc</i>L) phylogenetic analyses confirmed that the genus <i>Polysiphonia</i> Greville was polyphyletic, and currently assigned species resolved with many other genera. <i>Polysiphonia sensu stricto</i> was restricted to a group of species that formed a monophyletic lineage with the type, <i>Polysiphonia stricta. Carradoriella</i> P.C.Silva was resurrected based on the South African species <i>Carradoriella virgata</i> (C.Agardh) P.C.Silva. Species previously attributed to <i>Polysiphonia</i> were transferred to <i>Carradoriella, Leptosiphonia</i> and <i>Vertebrata</i> as well as to three new genera described here: <i>Acanthosiphonia</i> gen. nov., based on <i>A. echinata</i> (Harvey) comb. nov.; <i>Eutrichosiphonia</i> gen. nov. for <i>E. confusa</i> (Hollenberg) comb. nov. and <i>E. sabulosia</i> (B.Kim & M.S.Kim) comb. nov.; and <i>Kapraunia</i> gen. nov., which includes <i>K. schneideri</i> (Stuercke & Freshwater) comb. nov. and three additional species.
DOI: 10.6084/m9.figshare.7195430.v1
title: A molecular assessment of species diversity and generic boundaries in the red algal tribes Polysiphonieae and Streblocladieae (Rhodomelaceae, Rhodophyta) in Canada

description: Sequence data generated during a Canadian barcode survey (COI-5P) of the tribes Polysiphonieae and Streblocladieae, a large and taxonomically challenging group of red algae, revealed significant taxonomic confusion and hidden species diversity. <i>Polysiphonia pacifica</i> Hollenberg, <i>P. paniculata</i> Montagne, <i>P. stricta</i> (Dillwyn) Greville and <i>Vertebrata fucoides</i> (Hudson) Kuntze were all complexes of two or more genetically distinct yet overlooked species. One variety of <i>P. pacifica</i> was elevated to the rank of species as <i>P. determinata</i> (Hollenberg) Savoie & Saunders, stat. nov. Several new additions to the Canadian flora were recorded including <i>P. kapraunii</i> Stuercke & Freshwater and <i>P. morrowii</i> Harvey. Subsequent multi-gene (COI-5P, LSU and <i>rbc</i>L) phylogenetic analyses confirmed that the genus <i>Polysiphonia</i> Greville was polyphyletic, and currently assigned species resolved with many other genera. <i>Polysiphonia sensu stricto</i> was restricted to a group of species that formed a monophyletic lineage with the type, <i>Polysiphonia stricta. Carradoriella</i> P.C.Silva was resurrected based on the South African species <i>Carradoriella virgata</i> (C.Agardh) P.C.Silva. Species previously attributed to <i>Polysiphonia</i> were transferred to <i>Carradoriella, Leptosiphonia</i> and <i>Vertebrata</i> as well as to three new genera described here: <i>Acanthosiphonia</i> gen. nov., based on <i>A. echinata</i> (Harvey) comb. nov.; <i>Eutrichosiphonia</i> gen. nov. for <i>E. confusa</i> (Hollenberg) comb. nov. and <i>E. sabulosia</i> (B.Kim & M.S.Kim) comb. nov.; and <i>Kapraunia</i> gen. nov., which includes <i>K. schneideri</i> (Stuercke & Freshwater) comb. nov. and three additional species.
DOI: 10.7284/134412
title: Winch data collected during research cruise SR1912 using a Markey DETW-9-11 instrument system onboard the platform RV Sally Ride

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7195427.v1
title: Supplementary Information

description: These files are supplementary information to the publication: "Object Plane Detection and Phase Retrieval from Single-Shot Holograms using Multi-Wavelength In-Line Holography" by Hanqing Zhang, Tim Stangner, Krister Wiklund and Magnus Andersson.<br><br>Visualization 1 shows the object plane detection for red blood cells as a function of the iteration number. With increasing number of iterations, the peaks in the similarity index becomes more distinct and therefore object plane detection more precise. <br><br>Visualization 2 shows the accuracy of phase retrieval by using either 2 or 3 wavelengths for data acquisition. In general, the accuracy of phase retrieval can potentially be improved by increasing the number of wavelengths in our multi-wavelength iterative algorithm.
DOI: 10.7284/134413
title: Winch data collected during research cruise SR1912 using a Markey CAST-6-125 instrument system onboard the platform RV Sally Ride

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7195409
title: First treatment and retreatment of medically refractive trigeminal neuralgia by stereotactic radiosurgery versus microvascular decompression: a systematic review and Meta-analysis

description: <b>Purpose:</b> Procedures to treat medically refractory trigeminal neuralgia (MRTN) include stereotactic radiosurgery (SRS) and microvascular decompression (MVD). The aim of this study was to compare outcomes of SRS versus MVD in the treatment of MRTN, with a subgroup focus on those being treated for the first time. <b>Methods:</b> Search strategy was performed using the PRISMA guidelines for article identification, screening, eligibility and inclusion. Relevant articles were identified from six electronic databases from their inception to June 2017. These articles were screened against established criteria for inclusion into this study. Meta-analysis was conducted by pooling results with odds ratios and subgroup analysis. <b>Results:</b> From 13 relevant studies identified, 683 patients treated by SRS were compared with 670 patients treated by MVD for MRTN. Overall, the significant findings were that compared to MVD, SRS was associated with lower rates of short-term (OR = 0.16; 95%CI = 0.11–0.22; <i>p</i> p p p = .02), and more pain recurrence (OR = 2.28; 95%CI = 1.32–3.93; <i>p</i> = .003). These trends were all reflected in MRTN patients being treated for the first time. <b>Conclusion:</b> Both SRS and MVD alleviate pain in MRTN patients. MVD results in superior rates of short- and long-term pain relief, facial numbness and dysesthesia control, and less recurrence amongst those in whom pain freedom was achieved, at the cost of greater postoperative complications when compared to SRS. Although no significant difference was found in terms of the need for retreatment surgery, there was a trend towards less procedures favoring MVD. First treatment by either technique represents the overall trends reported.
DOI: 10.7284/134414
title: Winch data collected during research cruise SR1912 using a Markey CAST-6-125 instrument system onboard the platform RV Sally Ride

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7195409.v1
title: First treatment and retreatment of medically refractive trigeminal neuralgia by stereotactic radiosurgery versus microvascular decompression: a systematic review and Meta-analysis

description: <b>Purpose:</b> Procedures to treat medically refractory trigeminal neuralgia (MRTN) include stereotactic radiosurgery (SRS) and microvascular decompression (MVD). The aim of this study was to compare outcomes of SRS versus MVD in the treatment of MRTN, with a subgroup focus on those being treated for the first time. <b>Methods:</b> Search strategy was performed using the PRISMA guidelines for article identification, screening, eligibility and inclusion. Relevant articles were identified from six electronic databases from their inception to June 2017. These articles were screened against established criteria for inclusion into this study. Meta-analysis was conducted by pooling results with odds ratios and subgroup analysis. <b>Results:</b> From 13 relevant studies identified, 683 patients treated by SRS were compared with 670 patients treated by MVD for MRTN. Overall, the significant findings were that compared to MVD, SRS was associated with lower rates of short-term (OR = 0.16; 95%CI = 0.11–0.22; <i>p</i> p p p = .02), and more pain recurrence (OR = 2.28; 95%CI = 1.32–3.93; <i>p</i> = .003). These trends were all reflected in MRTN patients being treated for the first time. <b>Conclusion:</b> Both SRS and MVD alleviate pain in MRTN patients. MVD results in superior rates of short- and long-term pain relief, facial numbness and dysesthesia control, and less recurrence amongst those in whom pain freedom was achieved, at the cost of greater postoperative complications when compared to SRS. Although no significant difference was found in terms of the need for retreatment surgery, there was a trend towards less procedures favoring MVD. First treatment by either technique represents the overall trends reported.
DOI: 10.7284/134590
title: ADCP (Acoustic Doppler Current Profiler) data collected during research cruise SR1913 using a Hawaii UHDAS instrument system onboard the platform RV Sally Ride

description: Original (unprocessed) data collected during a Field_expedition