cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.30627173
title: Supplementary Material for: Selective Tumor Cytotoxicity via Singlet Oxygen Generation: Investigating Eosinophil Peroxidase and Myeloperoxidase in Cancer Therapy

description: Abstract
Introduction: Eosinophil peroxidase (EPO) and myeloperoxidase (MPO) are large, cationic enzymes secreted by granulocytes that bind preferentially to negatively charged cancer cell membranes produced by the Warburg effect. In the presence of halide cofactors and hydrogen peroxide (H₂O₂), and under acidic conditions that potentiate catalysis, they generate singlet oxygen (¹O₂*), a metastable oxygen state whose microsecond lifetime defines its diffusion radius and therefore its cytotoxic target. This confines reactivity to enzyme-enriched cancer cell surfaces, producing a spatially restricted therapeutic effect [Supplementary Note 1].
Methods: Human bladder cancer cell lines (5637, T24) and normal urothelial cells (SV-HUC1) were treated with porcine EPO (pEPO) or porcine MPO (pMPO) aggregate formulations in acidic medium (pH 5.3). Activation occurred upon addition of 10 mM H₂O₂ immediately prior to cell contact. Viability was assessed by MTS assay, and IC₅₀ values were determined by nonlinear regression. Mixed cultures of GFP⁺ SV-HUC1 and mCherry⁺ malignant cells were analyzed by fluorescence microscopy and flow cytometry. MPO localization was assessed by immunofluorescence, and DNA damage was evaluated by Western blotting for γH2AX and phospho-ATM. Independent toxicity of enzymes, cofactors, and peroxide was also tested.
Results: Aggregate formulations selectively eliminated bladder cancer cells while sparing SV-HUC1. IC₅₀ values were in the nanomolar range for malignant cells, with SV-HUC1 remaining viable at concentrations up to 200 nM. In mixed cultures, malignant cells were preferentially eliminated while GFP⁺ SV-HUC1 remained intact. Immunofluorescence confirmed MPO binding to malignant membranes, and DNA damage markers were induced only in cancer cells. Component testing showed no cytotoxicity from enzymes, cofactors, or 10 mM H₂O₂ alone; only higher peroxide concentrations produced injury.
Conclusion: Selective cytotoxicity arises from concurrent enzyme binding and ¹O₂* generation under acidic conditions, not from direct peroxide toxicity. Haloperoxidase therapy therefore offers a precise, contact-driven approach for post–bulk tumor treatment in non-muscle invasive bladder cancer. [Graphical Abstract]
DOI: 10.6084/m9.figshare.30627173.v1
title: Supplementary Material for: Selective Tumor Cytotoxicity via Singlet Oxygen Generation: Investigating Eosinophil Peroxidase and Myeloperoxidase in Cancer Therapy

description: Abstract
Introduction: Eosinophil peroxidase (EPO) and myeloperoxidase (MPO) are large, cationic enzymes secreted by granulocytes that bind preferentially to negatively charged cancer cell membranes produced by the Warburg effect. In the presence of halide cofactors and hydrogen peroxide (H₂O₂), and under acidic conditions that potentiate catalysis, they generate singlet oxygen (¹O₂*), a metastable oxygen state whose microsecond lifetime defines its diffusion radius and therefore its cytotoxic target. This confines reactivity to enzyme-enriched cancer cell surfaces, producing a spatially restricted therapeutic effect [Supplementary Note 1].
Methods: Human bladder cancer cell lines (5637, T24) and normal urothelial cells (SV-HUC1) were treated with porcine EPO (pEPO) or porcine MPO (pMPO) aggregate formulations in acidic medium (pH 5.3). Activation occurred upon addition of 10 mM H₂O₂ immediately prior to cell contact. Viability was assessed by MTS assay, and IC₅₀ values were determined by nonlinear regression. Mixed cultures of GFP⁺ SV-HUC1 and mCherry⁺ malignant cells were analyzed by fluorescence microscopy and flow cytometry. MPO localization was assessed by immunofluorescence, and DNA damage was evaluated by Western blotting for γH2AX and phospho-ATM. Independent toxicity of enzymes, cofactors, and peroxide was also tested.
Results: Aggregate formulations selectively eliminated bladder cancer cells while sparing SV-HUC1. IC₅₀ values were in the nanomolar range for malignant cells, with SV-HUC1 remaining viable at concentrations up to 200 nM. In mixed cultures, malignant cells were preferentially eliminated while GFP⁺ SV-HUC1 remained intact. Immunofluorescence confirmed MPO binding to malignant membranes, and DNA damage markers were induced only in cancer cells. Component testing showed no cytotoxicity from enzymes, cofactors, or 10 mM H₂O₂ alone; only higher peroxide concentrations produced injury.
Conclusion: Selective cytotoxicity arises from concurrent enzyme binding and ¹O₂* generation under acidic conditions, not from direct peroxide toxicity. Haloperoxidase therapy therefore offers a precise, contact-driven approach for post–bulk tumor treatment in non-muscle invasive bladder cancer. [Graphical Abstract]
DOI: 10.6084/m9.figshare.30627176
title: Supplementary Material for: Predictive Value of Cardiac Biomarkers Combined with Clinical, Radiological Factors for Venous Thromboembolism in Patients with Spontaneous Intracerebral Hemorrhage

description: Introduction
Venous thromboembolism (VTE) is an important complication after spontaneous intracerebral hemorrhage (ICH). However, it remains a clinical challenge to identify individuals at high risk for VTE in a population with ICH. This study aimed to develop a model integrating cardiac biomarkers with clinical-radiological factors for predicting VTE risk in patients with spontaneous ICH.
Methods
ICH patients were retrospectively enrolled between October 2019 and December 2022. Baseline clinical characteristics, laboratory data, and radiological features were collected. Patients with pulmonary embolism (PE) and deep vein thrombosis (DVT) were classified into the VTE group. Cox regression analysis was used to identify independent predictors of in-hospital VTE. A nomogram was developed based on the multivariate model, and its performance was evaluated using the concordance index (C-index), decision curve analysis (DCA), and net reclassification improvement (NRI).
Results
A total of 170 patients (mean age: 54.66 ± 13.6 years, 125 [73.5%] males) with ICH were included in the analysis. Thirty-six (21.2%) patients were assigned to the VTE group. Multivariate Cox analysis identified age (HR = 1.032, 95% CI: 1.002–1.062, p=0.033), baseline edema volume (HR = 1.034, 95% CI: 1.012–1.056, p=0.002), IVH (HR = 3.268, 95% CI: 1.635–6.530, p&lt;0.001), Myo (HR = 1.002, 95% CI: 1.000–1.003, p=0.010), and BNP (HR = 1.003, 95% CI: 1.001–1.006, p=0.007) as independent predictors. The combined model showed better predictive performance than the clinical-radiological model alone (C-index: 0.791 vs 0.749). The nomogram demonstrated good calibration and clinical utility across a wide risk threshold range.
Conclusion
Myo and BNP provide incremental predictive value for VTE risk stratification in ICH patients beyond traditional factors. The developed nomogram offers a practical tool for individualized risk assessment, potentially guiding optimized VTE prophylaxis strategies.
DOI: 10.6084/m9.figshare.30627176.v1
title: Supplementary Material for: Predictive Value of Cardiac Biomarkers Combined with Clinical, Radiological Factors for Venous Thromboembolism in Patients with Spontaneous Intracerebral Hemorrhage

description: Introduction
Venous thromboembolism (VTE) is an important complication after spontaneous intracerebral hemorrhage (ICH). However, it remains a clinical challenge to identify individuals at high risk for VTE in a population with ICH. This study aimed to develop a model integrating cardiac biomarkers with clinical-radiological factors for predicting VTE risk in patients with spontaneous ICH.
Methods
ICH patients were retrospectively enrolled between October 2019 and December 2022. Baseline clinical characteristics, laboratory data, and radiological features were collected. Patients with pulmonary embolism (PE) and deep vein thrombosis (DVT) were classified into the VTE group. Cox regression analysis was used to identify independent predictors of in-hospital VTE. A nomogram was developed based on the multivariate model, and its performance was evaluated using the concordance index (C-index), decision curve analysis (DCA), and net reclassification improvement (NRI).
Results
A total of 170 patients (mean age: 54.66 ± 13.6 years, 125 [73.5%] males) with ICH were included in the analysis. Thirty-six (21.2%) patients were assigned to the VTE group. Multivariate Cox analysis identified age (HR = 1.032, 95% CI: 1.002–1.062, p=0.033), baseline edema volume (HR = 1.034, 95% CI: 1.012–1.056, p=0.002), IVH (HR = 3.268, 95% CI: 1.635–6.530, p&lt;0.001), Myo (HR = 1.002, 95% CI: 1.000–1.003, p=0.010), and BNP (HR = 1.003, 95% CI: 1.001–1.006, p=0.007) as independent predictors. The combined model showed better predictive performance than the clinical-radiological model alone (C-index: 0.791 vs 0.749). The nomogram demonstrated good calibration and clinical utility across a wide risk threshold range.
Conclusion
Myo and BNP provide incremental predictive value for VTE risk stratification in ICH patients beyond traditional factors. The developed nomogram offers a practical tool for individualized risk assessment, potentially guiding optimized VTE prophylaxis strategies.
DOI: 10.6084/m9.figshare.30627179
title: Supplementary Material for: Idiopathic Posterior Scleritis Complicated by Optic Perineuritis and Ocular Motility Disorder Successfully Controlled with Adalimumab: A Case Report

description: Introduction: This report describes a rare case of idiopathic orbital inflammation with posterior scleritis complicated by optic perineuritis and ocular motility disorder.
Case presentation: A 22-year-old woman presented with right ocular pain, eyelid swelling, and blurring of vision for 5 days. Her best corrected visual acuity was 20/20 in the right eye, although a myopic shift was noted. An ocular motility disorder was identified on examination. Slit lamp and fundus examinations revealed diffuse scleral injection, anterior chamber inflammation, and serous retinal detachment. B-scan ultrasound showed thickening of the choroid and sclera. Gadolinium-enhanced MRI revealed marked thickening and enhancement of the right optic nerve sheath. Humphrey visual field testing showed an enlarged blind spot and an inferior field defect. The systemic work-up and laboratory tests were unremarkable, aside from elevated CRP and ESR. The patient was diagnosed with idiopathic orbital inflammation with posterior scleritis, optic perineuritis, and ocular motility disorder. Treatment with oral prednisolone (50 mg/day) improved all ocular findings, but a relapse occurred while tapering to 10 mg/day. The symptoms resolved after increasing the dose of prednisolone, and adalimumab was added to prevent recurrence. Adalimumab was continued while tapering prednisolone and replacing it with oral hydrocortisone for secondary adrenal insufficiency. Six months after the discontinuation of prednisolone, the patient remains in remission. 
Conclusion: This rare case of idiopathic orbital inflammation with posterior scleritis, optic perineuritis, and ocular motility disorder was successfully controlled with adalimumab after relapse, suggesting its efficacy in preventing recurrence.
DOI: 10.6084/m9.figshare.30627179.v1
title: Supplementary Material for: Idiopathic Posterior Scleritis Complicated by Optic Perineuritis and Ocular Motility Disorder Successfully Controlled with Adalimumab: A Case Report

description: Introduction: This report describes a rare case of idiopathic orbital inflammation with posterior scleritis complicated by optic perineuritis and ocular motility disorder.
Case presentation: A 22-year-old woman presented with right ocular pain, eyelid swelling, and blurring of vision for 5 days. Her best corrected visual acuity was 20/20 in the right eye, although a myopic shift was noted. An ocular motility disorder was identified on examination. Slit lamp and fundus examinations revealed diffuse scleral injection, anterior chamber inflammation, and serous retinal detachment. B-scan ultrasound showed thickening of the choroid and sclera. Gadolinium-enhanced MRI revealed marked thickening and enhancement of the right optic nerve sheath. Humphrey visual field testing showed an enlarged blind spot and an inferior field defect. The systemic work-up and laboratory tests were unremarkable, aside from elevated CRP and ESR. The patient was diagnosed with idiopathic orbital inflammation with posterior scleritis, optic perineuritis, and ocular motility disorder. Treatment with oral prednisolone (50 mg/day) improved all ocular findings, but a relapse occurred while tapering to 10 mg/day. The symptoms resolved after increasing the dose of prednisolone, and adalimumab was added to prevent recurrence. Adalimumab was continued while tapering prednisolone and replacing it with oral hydrocortisone for secondary adrenal insufficiency. Six months after the discontinuation of prednisolone, the patient remains in remission. 
Conclusion: This rare case of idiopathic orbital inflammation with posterior scleritis, optic perineuritis, and ocular motility disorder was successfully controlled with adalimumab after relapse, suggesting its efficacy in preventing recurrence.
DOI: 10.34740/kaggle/dsv/13740937
title: Public Opinion on Climate Change (Updated Daily)
DOI: 10.15468/dl.2xdavp
title: Occurrence Download

description: A dataset containing 140367 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is China",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "TaxonKey is Pycnonotus",
 "Year 2010-2025"
 ]
}

 The dataset includes 140367 records from 16 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0035100-251025141854904/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.qq9zrm
title: Occurrence Download

description: A dataset containing 25 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Mikrogeophagus ramirezi",
 "HasCoordinate is true",
 "Geometry POLYGON((-78 12, -73 12, -73 0, -78 0, -78 12))"
 ]
}

 The dataset includes 25 records from 6 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0035162-251025141854904/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.6084/m9.figshare.30627158
title: <b>Multi-level Spatiotemporal Dataset of Land Transfer in China (2000 to 2024)</b>

description: In China's hierarchical land-governance system, the central government establishes the regulatory framework, while provincial and municipal authorities adapt the implementation according to local fiscal capacity, development priorities, and spatial constraints. However, empirical studies have long relied on fragmented or city-specific samples, and there is still no unified dataset that captures the institutional evolution of land transfer across multiple administrative levels over a long time span. To bridge this gap, this study constructs a multi-level spatiotemporal dataset of land transfer in China from 2000 to 2024 at the national, provincial, and city levels.The dataset integrates seven core indicators under a standardized statistical specification: land supply area, transaction price, gross floor area (GFA), payment amount, floor area ratio (FAR), building density, and greenery rate. Data are sourced from official land-market disclosures and verified administrative transaction records, and undergo multi-stage quality control including cross-source reconciliation, unit harmonization, and outlier screening to ensure temporal consistency and cross-regional comparability. The dataset supports both macro-level trajectory tracing and subnational spatial heterogeneity analysis, and is accompanied by a series of visualization outputs depicting long-term land supply dynamics, regional structural divergence, and spatial clustering patterns. This dataset fills a foundational empirical gap for research on China's land-governance mechanism, land finance, urban spatial form, and the institutional transition toward high-quality development.
DOI: 10.6084/m9.figshare.30627158.v1
title: <b>Multi-level Spatiotemporal Dataset of Land Transfer in China (2000 to 2024)</b>

description: In China's hierarchical land-governance system, the central government establishes the regulatory framework, while provincial and municipal authorities adapt the implementation according to local fiscal capacity, development priorities, and spatial constraints. However, empirical studies have long relied on fragmented or city-specific samples, and there is still no unified dataset that captures the institutional evolution of land transfer across multiple administrative levels over a long time span. To bridge this gap, this study constructs a multi-level spatiotemporal dataset of land transfer in China from 2000 to 2024 at the national, provincial, and city levels.The dataset integrates seven core indicators under a standardized statistical specification: land supply area, transaction price, gross floor area (GFA), payment amount, floor area ratio (FAR), building density, and greenery rate. Data are sourced from official land-market disclosures and verified administrative transaction records, and undergo multi-stage quality control including cross-source reconciliation, unit harmonization, and outlier screening to ensure temporal consistency and cross-regional comparability. The dataset supports both macro-level trajectory tracing and subnational spatial heterogeneity analysis, and is accompanied by a series of visualization outputs depicting long-term land supply dynamics, regional structural divergence, and spatial clustering patterns. This dataset fills a foundational empirical gap for research on China's land-governance mechanism, land finance, urban spatial form, and the institutional transition toward high-quality development.
DOI: 10.5281/zenodo.17615779
title: SwiftMHC suppelementary data

description: Supplementary data for publication: https://doi.org/10.1101/2025.01.20.633893.Contains data collected on 7726 IEDB 9-mer HLA-A*02:01 peptide MHC complexes.

Contains data collected on 202 X-ray structures of 9-mer HLA-A*02:01 peptide MHC complexes.
DOI: 10.15468/dl.9vghv5
title: Occurrence Download

description: A dataset containing 43 species occurrences available in GBIF matching the query:
{
 "Geometry" : [
 "POLYGON ((-109.1688 24.44913, -109.0188 24.44913, -109.0188 24.59913, -109.1688 24.59913, -109.1688 24.44913))"
 ]
}

 The dataset includes 43 records from 8 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0035163-251025141854904/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.5sj844
title: Occurrence Download

description: A dataset containing 5536 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Monstera deliciosa"
 ]
}

 The dataset includes 5536 records from 245 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0035161-251025141854904/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.7931/psc4-9v96
title: Investigating interspecific mating in the thelytokous predatory mite Amblyseius herbicolus
DOI: 10.15468/dl.dw4gtb
title: Occurrence Download

description: A dataset containing 36448 species occurrences available in GBIF matching the query:
{
 "and" : [
 "HasCoordinate is true",
 "TaxonKey is Streptomyces Waksman & Henrici, 1943"
 ]
}

 The dataset includes 36448 records from 425 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0016267-250525065834625/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.18739/a28w38439
title: Goddard Institute for Space Studies Surface Temperature Analysis (GISTEMP v4)

description: Goddard Institute for Space Studies (GISS) Surface Temperature Analysis version 4 (GISTEMP v4) is an estimate of global surface temperature change. Graphs and tables are updated around the middle of every month using current data files from National Oceanic and Atmospheric Administration (NOAA) Global Historical Climatology Network (GHCN) v4 (meteorological stations) and Extended Reconstructed Sea Surface Temperature (ERSST) v5 (ocean areas), combined as described in our publications Hansen et al. (2010) and Lenssen et al. (2019). These updated files incorporate reports for the previous month and also late reports and corrections for earlier months.
DOI: 10.18739/a26m3356r
title: Metal Concentrations in Tundra Seep, Tributary and River Waters of the Western Brooks Range, Alaska, 2022-2023

description: Historically characterized by pristine streams that support robust populations of Arctic grayling, Dolly Varden, and chum salmon, the southern slopes of the Brooks Range provide valuable economic and subsistence resources for local communities. However, since 2019, dozens of formerly clear-running streams have turned turbid and orange with iron precipitates. Seeps have been identified in the tundra and in upland rock formations. Limited data show very low pH in seep water (less than 3.0), downslope vegetation mortality, and dramatic declines in juvenile fish abundance in affected headwaters. The causes of this rapidly spreading degradation of pristine streams remains unknown. The proliferation of turbid orange streams west of the Dalton Highway ( greater than 30 since 2019) is a threat to wilderness characteristics, drinking water, subsistence resource availability, and a growing commercial salmon fishery in northwest Alaska. With many terrestrial and aquatic species dependent upon the seasonal influx of salmon, the loss of fish habitat could induce ecosystem collapse, despite the protections afforded by a vast network of National Parks and Preserves. The degradation of formerly pristine streams is occurring at such a rapid pace that we may soon lose the opportunity to compare affected with nearby unaffected streams. This comparison is essential to develop the mechanistic, causal understanding that would allow us to predict which streams will turn next and the threats to downstream villages. The community of Kiana, for instance, sits at the confluence of the Squirrel and Kobuk Rivers. At least two streams in the Squirrel watershed have turned since 2020, while two large tributaries of the Kobuk turned in 2019. The Squirrel and large Kobuk tributaries, like the Salmon River, produce much of the fish harvested by Kiana residents. This dataset includes field measurements of pH, specific conductivity, dissolved oxygen and turbidity, along with laboratory measurements of metal concentrations in acidified water samples from tundra seeps, tributaries and rivers in the western Brooks Range. The watersheds that were sampled include Timber Creek, Tukpahlearik Creek, Salmon River, Kallarichuk River, Kobuk River and Devil's Lake, which is the drinking water source for the village of Kotzebue, Alaska.
DOI: 10.6084/m9.figshare.28562546
title: Dataframes with survey results - intensity zones

description: Survey results.
DOI: 10.6084/m9.figshare.28562546.v1
title: Dataframes with survey results - intensity zones

description: Survey results.
DOI: 10.15468/dl.s4szxu
title: Occurrence Download

description: A dataset containing 550 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Populus tomentosa"
 ]
}

 The dataset includes 550 records from 43 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0049637-250811113504898/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.34740/kaggle/dsv/12818184
title: Peer-to-Peer Boliviano (BOB) Exchange Data