cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.7472057
title: Supplementary Material for: Downregulation of Microparticle Release and Pro-Inflammatory Properties of Activated Human Polymorphonuclear Neutrophils by LMW Fucoidan

description: Exposition of neutrophils (polymorphonuclear neutrophils, PMNs) to bacterial products triggers exacerbated activation of these cells, increasing their harmful effects on host tissues. We evaluated the possibility of interfering with the classic immune innate responses of human PMNs exposed to bacterial endotoxin (lipopolysaccharide, LPS), and further stimulated with bacterial formyl peptide (N-formyl-methionine-leucine-phenylalanine, fMLP). We showed that the low- molecular-weight fucoidan (LMW-Fuc), a polysaccharide extracted from brown algae, attenuated the exacerbated activation induced by fMLP on LPS-primed PMNs, in vitro, impairing chemotaxis, NET formation, and the pro-survival and pro-oxidative effects. LMW-Fuc also inhibited the activation of canonical signaling pathways, AKT, bad, p47<i>phox</i> and MLC, activated by the exposition of PMN to bacterial products. The activation of PMN by sequential exposure to LPS and fMLP induced the release of L-selectin<sup>+</sup> microparticles, which were able to trigger extracellular reactive oxygen species production by fresh PMNs and macrophages. Furthermore, we observed that LMW-Fuc inhibited microparticle release from activated PMN. In vivo<i></i> experiments showed that circulating PMN-derived microparticles could be detected in mice exposed to bacterial products (LPS/fMLP), being downregulated in animals treated with LMW-Fuc. The data highlight the autocrine and paracrine role of pro-inflammatory microparticles derived from activated PMN and demonstrate the anti-inflammatory effects of LMW-Fuc on these cells.
DOI: 10.6084/m9.figshare.7472057.v1
title: Supplementary Material for: Downregulation of Microparticle Release and Pro-Inflammatory Properties of Activated Human Polymorphonuclear Neutrophils by LMW Fucoidan

description: Exposition of neutrophils (polymorphonuclear neutrophils, PMNs) to bacterial products triggers exacerbated activation of these cells, increasing their harmful effects on host tissues. We evaluated the possibility of interfering with the classic immune innate responses of human PMNs exposed to bacterial endotoxin (lipopolysaccharide, LPS), and further stimulated with bacterial formyl peptide (N-formyl-methionine-leucine-phenylalanine, fMLP). We showed that the low- molecular-weight fucoidan (LMW-Fuc), a polysaccharide extracted from brown algae, attenuated the exacerbated activation induced by fMLP on LPS-primed PMNs, in vitro, impairing chemotaxis, NET formation, and the pro-survival and pro-oxidative effects. LMW-Fuc also inhibited the activation of canonical signaling pathways, AKT, bad, p47<i>phox</i> and MLC, activated by the exposition of PMN to bacterial products. The activation of PMN by sequential exposure to LPS and fMLP induced the release of L-selectin<sup>+</sup> microparticles, which were able to trigger extracellular reactive oxygen species production by fresh PMNs and macrophages. Furthermore, we observed that LMW-Fuc inhibited microparticle release from activated PMN. In vivo<i></i> experiments showed that circulating PMN-derived microparticles could be detected in mice exposed to bacterial products (LPS/fMLP), being downregulated in animals treated with LMW-Fuc. The data highlight the autocrine and paracrine role of pro-inflammatory microparticles derived from activated PMN and demonstrate the anti-inflammatory effects of LMW-Fuc on these cells.
DOI: 10.6084/m9.figshare.7472036
title: Differentially expressed genes between core and invasion GBM areas : RNAseq

description: DEGs of core and GBM invasive areas<br>
DOI: 10.7284/112273
title: TSG (Thermosalinograph) data collected during research cruise MGL1310 using a Sea-Bird SBE-21 instrument system onboard the platform RV Marcus G. Langseth

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7471994
title: Supplementary Material for: The Role of Toll-Like Receptors in the Production of Cytokines by Human Lung Macrophages

description: <b><i>Background:</i></b> The Toll-like receptor (TLR) family is involved in the recognition of and response to microbial infections. These receptors are expressed in leukocytes. TLR stimulation induces the production of proinflammatory cytokines and chemokines. Given that human lung macrophages (LMs) constitute the first line of defense against inhaled pathogens, the objective of this study was to investigate the expression and function of TLR subtypes in this cell population. <b><i>Methods:</i></b> Human primary LMs were obtained from patients undergoing surgical resection. The RNA and protein expression levels of TLRs, chemokines, and cytokines were assessed after incubation with subtype-selective agonists. <b><i>Results:</i></b> In human LMs, the TLR expression level varied from one subtype to another. Stimulation with subtype-selective agonists induced an intense, concentration- and time-dependent increase in the production of chemokines and cytokines. TLR4 stimulation induced the strongest effect, whereas TLR9 stimulation induced a much weaker response. <b><i>Conclusions:</i></b> The stimulation of TLRs in human LMs induces intense cytokine and chemokine production, a characteristic of the proinflammatory M1 macrophage phenotype.
DOI: 10.6084/m9.figshare.7471994.v1
title: Supplementary Material for: The Role of Toll-Like Receptors in the Production of Cytokines by Human Lung Macrophages

description: <b><i>Background:</i></b> The Toll-like receptor (TLR) family is involved in the recognition of and response to microbial infections. These receptors are expressed in leukocytes. TLR stimulation induces the production of proinflammatory cytokines and chemokines. Given that human lung macrophages (LMs) constitute the first line of defense against inhaled pathogens, the objective of this study was to investigate the expression and function of TLR subtypes in this cell population. <b><i>Methods:</i></b> Human primary LMs were obtained from patients undergoing surgical resection. The RNA and protein expression levels of TLRs, chemokines, and cytokines were assessed after incubation with subtype-selective agonists. <b><i>Results:</i></b> In human LMs, the TLR expression level varied from one subtype to another. Stimulation with subtype-selective agonists induced an intense, concentration- and time-dependent increase in the production of chemokines and cytokines. TLR4 stimulation induced the strongest effect, whereas TLR9 stimulation induced a much weaker response. <b><i>Conclusions:</i></b> The stimulation of TLRs in human LMs induces intense cytokine and chemokine production, a characteristic of the proinflammatory M1 macrophage phenotype.
DOI: 10.7284/114786
title: Expendable Probe data collected during research cruise MGL1405 using a Sippican MK21 instrument system onboard the platform RV Marcus G. Langseth

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7471979
title: Anti-infective potential of hydroalcoholic extract of Punica granatum peel against gram-negative bacterial pathogens

description: Appendix A: Raw data pertaining to the paper entitled "Anti-infective potential of hydroalcoholic extract of <i>Punica granatum</i> peel against gram-negative bacterial pathogens.<br>Appendix S: Supplementary (Extended) Data for above paper.
DOI: 10.7284/114790
title: GNSS (Global Navigation Satellite System) data collected during research cruise MGL1405 using a C&C C-Nav 3050 instrument system onboard the platform RV Marcus G. Langseth

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7471979.v2
title: Anti-infective potential of hydroalcoholic extract of Punica granatum peel against gram-negative bacterial pathogens

description: Appendix A: Raw data pertaining to the paper entitled "Anti-infective potential of hydroalcoholic extract of <i>Punica granatum</i> peel against gram-negative bacterial pathogens.<br>Appendix S: Supplementary (Extended) Data for above paper.
DOI: 10.6084/m9.figshare.7471946
title: Datasets for the real data analysis

description: Two datasets analyzed in the real data analysis.
DOI: 10.6084/m9.figshare.7471979.v1
title: Anti-infective potential of hydroalcoholic extract of Punica granatum peel against gram-negative bacterial pathogens

description: Raw data pertaining to the paper entitled "Anti-infective potential of hydroalcoholic extract of <i>Punica granatum</i> peel against gram-negative bacterial pathogens:.
DOI: 10.7284/114794
title: GNSS (Global Navigation Satellite System) data collected during research cruise MGL1405 using a C&C C-Nav 2000 instrument system onboard the platform RV Marcus G. Langseth

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7471934
title: Datasets in the sensitivity analysis

description: Simulated datasets in the sensitivity analysis with the true parameters that generated the data.
DOI: 10.7284/114795
title: Gravimeter data collected during research cruise MGL1405 using a Bell BGM-3 instrument system onboard the platform RV Marcus G. Langseth

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7471853
title: APLP2 Analysis data.xls

description: This is an analysis of the association between the polymorphism of the amyloid precursor-like protein 2 (APLP2) locus rs2054247 and coronary heart disease (CHD) in Chinese Han and Uygur nationalities.
DOI: 10.6084/m9.figshare.7471919
title: Datasets in the simulation study

description: Datasets analyzed in the simulation study with the true values of parameters that generated the data.
DOI: 10.7284/114793
title: Gyrocompass data collected during research cruise MGL1405 using a Kongsberg Simrad GC80 instrument system onboard the platform RV Marcus G. Langseth

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7471853.v1
title: APLP2 Analysis data.xls

description: This is an analysis of the association between the polymorphism of the amyloid precursor-like protein 2 (APLP2) locus rs2054247 and coronary heart disease (CHD) in Chinese Han and Uygur nationalities.
DOI: 10.7284/114791
title: INS (Inertial Navigation System) data collected during research cruise MGL1405 using a Kongsberg Seapath 200 instrument system onboard the platform RV Marcus G. Langseth

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/114796
title: INS (Inertial Navigation System) data collected during research cruise MGL1405 using a Applanix POS/MV-320 V3 instrument system onboard the platform RV Marcus G. Langseth

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7471697
title: Functional annotation with Blast2GO predicted for the new loci and the DEGs.

description: Supplementary file of the paper "Genome-wide analysis of the transcriptional response to drought stress in root and leaf of common bean".
DOI: 10.7284/114799
title: Meteorological Station data collected during research cruise MGL1405 using a RM Young 26700 instrument system onboard the platform RV Marcus G. Langseth

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7471568
title: Forecasting Stock Prices with a Feature Fusion LSTM-CNN Model Using Different Representations of the Same Data

description: This data is 1minute SPY dataset from October 14, 2016 to October 16, 2017.
DOI: 10.7284/114787
title: Multibeam Echosounder data collected during research cruise MGL1405 using a Kongsberg EM122 instrument system onboard the platform RV Marcus G. Langseth

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/114798
title: pCO2 (Partial Pressure of Carbon Dioxide) data collected during research cruise MGL1405 using a LDEO pCO2 instrument system onboard the platform RV Marcus G. Langseth

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/114789
title: Singlebeam Echosounder data collected during research cruise MGL1405 using a Knudsen 3260 instrument system onboard the platform RV Marcus G. Langseth

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/114788
title: Speedlog data collected during research cruise MGL1405 using a Furuno DS-50 instrument system onboard the platform RV Marcus G. Langseth

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.17608/k6.auckland.7471526
title: Rendering HTML Content in R Graphics

description: This report describes several R packages that allow HTML content to be rendered as part of an R plot. The core package is called 'layoutEngine', but that package requires a "backend" package to perform HTML layout calculations. Three example backends are demonstrated: 'layoutEngineCSSBox', 'layoutEnginePhantomJS', and 'layoutEngineDOM'. We also introduce two new font packages, 'gyre' and 'courier'.
DOI: 10.17608/k6.auckland.7471526.v1
title: Rendering HTML Content in R Graphics

description: This report describes several R packages that allow HTML content to be rendered as part of an R plot. The core package is called 'layoutEngine', but that package requires a "backend" package to perform HTML layout calculations. Three example backends are demonstrated: 'layoutEngineCSSBox', 'layoutEnginePhantomJS', and 'layoutEngineDOM'. We also introduce two new font packages, 'gyre' and 'courier'.
DOI: 10.7284/114792
title: TSG (Thermosalinograph) data collected during research cruise MGL1405 using a Sea-Bird SBE-21 instrument system onboard the platform RV Marcus G. Langseth

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/114802
title: Expendable Probe data collected during research cruise MGL1407 using a Sippican MK21 instrument system onboard the platform RV Marcus G. Langseth

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/114807
title: GNSS (Global Navigation Satellite System) data collected during research cruise MGL1407 using a C&C C-Nav 3050 instrument system onboard the platform RV Marcus G. Langseth

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.26180/5c372a47334a6
title: Clustering Interval Time Series by Elizabeth Ann Maharaj, Paulo Teles, Paula Brito

description: <b>Supplementary Material</b><br><b><br></b><b>Data files</b><br><b><br></b><b>Figures A1 - A8: Simulations Boxplots</b><b><br></b><b>Figures B1: B16: </b><b>Application </b><b>Dendrograms </b><b><br></b><b>Software: R and Matlab</b><br><br>
DOI: 10.7284/114811
title: GNSS (Global Navigation Satellite System) data collected during research cruise MGL1407 using a C&C C-Nav 2000 instrument system onboard the platform RV Marcus G. Langseth

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7471472
title: Light Sheet microscopy of Astrocytes.avi

description: <b>Superresolved light sheet microscopy of mouse brain Astrocytes</b> A 100µm thick block of cleared mouse brain embedded in a pluronic gel. The astrocytes are anti-GFAP/CY<sub>3</sub> stained. XY Scales : 2mmX1.8mm for low resolution.450 µmX340µm for medium resolution.220µmX180µm for High resolutionSuperresolved sheet thickness around 1µm. <b></b><i></i><sub></sub><sup></sup><br>In addition to astrocytes some amyloid plaques (better shown at low magnification) are imaged via their endofluoresecence. The animal model is a 12 months old cleared AD mouse (APP:PS1-21 lines). <br><br>
DOI: 10.7284/114812
title: Gravimeter data collected during research cruise MGL1407 using a Bell BGM-3 instrument system onboard the platform RV Marcus G. Langseth

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/114810
title: Gyrocompass data collected during research cruise MGL1407 using a Kongsberg Simrad GC80 instrument system onboard the platform RV Marcus G. Langseth

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7471418
title: op-amp calibration data

description: op-amp calibration data used in the report
DOI: 10.6084/m9.figshare.7471421
title: Temperature calibration runs data

description: Temperature calibration runs data
DOI: 10.6084/m9.figshare.7471424
title: Pulse sample data

description: Pulse sample data
DOI: 10.6084/m9.figshare.7471418.v1
title: op-amp calibration data

description: op-amp calibration data used in the report
DOI: 10.6084/m9.figshare.7471421.v1
title: Temperature calibration runs data

description: Temperature calibration runs data
DOI: 10.6084/m9.figshare.7471424.v1
title: Pulse sample data

description: Pulse sample data
DOI: 10.7284/114808
title: INS (Inertial Navigation System) data collected during research cruise MGL1407 using a Kongsberg Seapath 200 instrument system onboard the platform RV Marcus G. Langseth

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7471391
title: OCTA Artifacts Plos One

description: Please see <i>DOI: 10.1371/journal.pone.0210505</i>
DOI: 10.7284/114813
title: INS (Inertial Navigation System) data collected during research cruise MGL1407 using a Applanix POS/MV-320 V3 instrument system onboard the platform RV Marcus G. Langseth

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/114805
title: Magnetometer data collected during research cruise MGL1407 using a Geometrics G-882 instrument system onboard the platform RV Marcus G. Langseth

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7471361
title: Enrichment analysis

description: Enrichment analysis for each set of protein corona files, calculated by normalizing protein expression to the background expression of proteins detected in controls.
DOI: 10.7284/114815
title: Meteorological Station data collected during research cruise MGL1407 using a RM Young 26700 instrument system onboard the platform RV Marcus G. Langseth

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7471352
title: Plasma then washed blood samples

description: Detected corona for particles after incubation in plasma washed blood, as well as washed blood control sample.
DOI: 10.6084/m9.figshare.7471358
title: Processed protein abundances

description: Abundances of proteins identified in the protein corona, calculated using the raw NSAF values, removing non secreted proteins, and re-normalizing remaining data.
DOI: 10.6084/m9.figshare.7471361.v1
title: Enrichment analysis

description: Enrichment analysis for each set of protein corona files, calculated by normalizing protein expression to the background expression of proteins detected in controls.
DOI: 10.6084/m9.figshare.7471391.v1
title: OCTA Artifacts Plos One

description: Please see <i>DOI: 10.1371/journal.pone.0210505</i>
DOI: 10.6084/m9.figshare.7471349
title: Washed blood samples

description: Detected corona for particles after incubation in washed blood, as well as washed blood control sample.
DOI: 10.6084/m9.figshare.7471358.v1
title: Processed protein abundances

description: Abundances of proteins identified in the protein corona, calculated using the raw NSAF values, removing non secreted proteins, and re-normalizing remaining data.
DOI: 10.7284/114803
title: Multibeam Echosounder data collected during research cruise MGL1407 using a Kongsberg EM122 instrument system onboard the platform RV Marcus G. Langseth

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7471346
title: Plasma samples

description: Detected corona for particles after incubation in plasma, as well as plasma control sample.
DOI: 10.6084/m9.figshare.7471349.v1
title: Washed blood samples

description: Detected corona for particles after incubation in washed blood, as well as washed blood control sample.
DOI: 10.6084/m9.figshare.7471352.v1
title: Plasma then washed blood samples

description: Detected corona for particles after incubation in plasma washed blood, as well as washed blood control sample.
DOI: 10.6084/m9.figshare.7471343
title: Raw proteomics output

description: Raw proteomics output for all samples, including controls. This includes the normalized spectral abundance factor for all samples in the dataset, along with a "mapping sheet" describing what each sample is.
DOI: 10.6084/m9.figshare.7471346.v1
title: Plasma samples

description: Detected corona for particles after incubation in plasma, as well as plasma control sample.
DOI: 10.7284/114814
title: pCO2 (Partial Pressure of Carbon Dioxide) data collected during research cruise MGL1407 using a LDEO pCO2 instrument system onboard the platform RV Marcus G. Langseth

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/114806
title: Singlebeam Echosounder data collected during research cruise MGL1407 using a Knudsen 3260 instrument system onboard the platform RV Marcus G. Langseth

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/114804
title: Speedlog data collected during research cruise MGL1407 using a Furuno DS-50 instrument system onboard the platform RV Marcus G. Langseth

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/114809
title: TSG (Thermosalinograph) data collected during research cruise MGL1407 using a Sea-Bird SBE-21 instrument system onboard the platform RV Marcus G. Langseth

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7471313
title: Additional file 4: of Properties of LINE-1 proteins and repeat element expression in the context of amyotrophic lateral sclerosis

description: Table S3. Summary of significant individual DE TE loci in the GSE67196 RNA-Seq dataset. (XLSX 774 kb)
DOI: 10.7284/114818
title: Expendable Probe data collected during research cruise MGL1408 using a Sippican MK21 instrument system onboard the platform RV Marcus G. Langseth

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7471313.v1
title: Additional file 4: of Properties of LINE-1 proteins and repeat element expression in the context of amyotrophic lateral sclerosis

description: Table S3. Summary of significant individual DE TE loci in the GSE67196 RNA-Seq dataset. (XLSX 774 kb)
DOI: 10.6084/m9.figshare.7471307
title: Additional file 2: of Properties of LINE-1 proteins and repeat element expression in the context of amyotrophic lateral sclerosis

description: Table S1. Summary of significant DE TE subfamilies determined by TEtranscripts RNA-Seq datasets. (XLSX 326 kb)
DOI: 10.7284/114823
title: GNSS (Global Navigation Satellite System) data collected during research cruise MGL1408 using a C&C C-Nav 3050 instrument system onboard the platform RV Marcus G. Langseth

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/114827
title: GNSS (Global Navigation Satellite System) data collected during research cruise MGL1408 using a C&C C-Nav 2000 instrument system onboard the platform RV Marcus G. Langseth

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/114828
title: Gravimeter data collected during research cruise MGL1408 using a Bell BGM-3 instrument system onboard the platform RV Marcus G. Langseth

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/114826
title: Gyrocompass data collected during research cruise MGL1408 using a Kongsberg Simrad GC80 instrument system onboard the platform RV Marcus G. Langseth

description: Original (unprocessed) data collected during a Field_expedition