cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.5066/p13w5y9w
title: Airborne magnetic and radiometric survey, South Pass-Granite Mountains region, Wyoming, 2023

description: This data release provides digital flight line data for a high-resolution airborne magnetic and radiometric survey over the South Pass-Granite Mountains region in central Wyoming. The airborne survey was funded by the state of Wyoming, designed by the Wyoming State Geological Survey (WSGS), and contracted by the USGS. The survey is aligned with the Earth Mapping Resources Initiative and was designed to meet complementary needs related to geologic mapping and characterization of mineral resource potential. A total of 47,973.8 line km of magnetic and radiometric data were acquired over an area of 8639 km. Data were collected from a helicopter flown at a nominal terrain clearance of 100 meters (m) above topography along N-S flight lines spaced at 200 m intervals. Tie lines were flown in an E-W direction every 2000 m. Data were collected by New Sense Geophysics Ltd. and Merrick-Surdex Joint Venture under contract to the USGS using a helicopter with a magnetometer mounted in a stinger and a fully calibrated gamma-ray spectrometer. The survey operated out of airports in Rawlins and Lander, Wyoming, from July of 2023 to September of 2023. Files that are available in this publication include flight line data for the magnetic survey, flight line data for the radiometric survey and a report describing the survey parameters, field operations, quality control and data reduction procedures. A zip file is provided that contains the contractor's deliverable products that includes Geosoft databases and grids for the magnetic and radiometric survey and the report describing the survey and data reduction.
DOI: 10.6084/m9.figshare.21840504
title: The Multi-Modal Evaluation of Sensory Sensitivity (MESSY): assessing a commonly missed symptom of acquired brain injury

description: Datasets for the manuscript: 'The Multi-Modal Evaluation of Sensory Sensitivity (MESSY): 
assessing a commonly missed symptom of acquired brain injury'
<br>
DOI: 10.6084/m9.figshare.21840504.v1
title: The Multi-Modal Evaluation of Sensory Sensitivity (MESSY): assessing a commonly missed symptom of acquired brain injury

description: Datasets for the manuscript: 'The Multi-Modal Evaluation of Sensory Sensitivity (MESSY): 
assessing a commonly missed symptom of acquired brain injury'
<br>
DOI: 10.6084/m9.figshare.14385237
title: Additional file 1 of The prognosis of recurrent low-grade endometrial stromal sarcoma: a retrospective cohort study

description: Additional file 1. Raw data of this study.
DOI: 10.6084/m9.figshare.14396511.v1
title: Additional file 2 of Genome-wide analysis of long noncoding RNA expression profile in nasal mucosa with allergic rhinitis

description: Additional file 2: Table S2. The differentially expressed mRNAs and lncRNAs.
DOI: 10.6084/m9.figshare.12299369.v1
title: Additional file 5 of Identification and analysis of CYP450 and UGT supergene family members from the transcriptome of Aralia elata (Miq.) seem reveal candidate genes for triterpenoid saponin biosynthesis

description: Additional file 5: Table S3. List of 92 UGTs of A. elata identified in this study.
DOI: 10.6084/m9.figshare.12299339.v1
title: Additional file 11 of Identification and analysis of CYP450 and UGT supergene family members from the transcriptome of Aralia elata (Miq.) seem reveal candidate genes for triterpenoid saponin biosynthesis

description: Additional file 11: Table S8. Sequences of the primers used in this study.
DOI: 10.6084/m9.figshare.18590937.v1
title: X-Linked Tumor Suppressor Genes Act as Presumed Contributors in the Sex Chromosome-Autosome Crosstalk in Cancers

description: Since the human genome contains about 6% of tumor suppressor genes (TSGs) and the X chromosome alone holds a substantial share (2%), herein, we have discussed exclusively the relative contribution of X-linked human TSGs that appear to be primarily involved in 32 different cancer types. Our analysis showed that, (a) the majority of X-linked TSGs are primarily involved in the dysregulation of breast cancer, followed by prostate cancer, (b) Despite being escaped from X chromosome inactivation (XCI), a clear pattern of altered promoter methylation linked to the mutational burden was observed among them. (c) X-linked TSGs (mainly on the q-arm) maintain spatial and genetic interactions with certain autosomal loci. Corroborating our previous findings that loss/gain of entire sex chromosomes (in XO and XXY syndromes) can profoundly affect the epigenetic status of autosomes we herein suggest that X-linked TSGs alone can also contribute significantly in the dynamics this sex chromosome-autosome crosstalk to restructure the cancer genome.
DOI: 10.6084/m9.figshare.12299363
title: Additional file 4 of Identification and analysis of CYP450 and UGT supergene family members from the transcriptome of Aralia elata (Miq.) seem reveal candidate genes for triterpenoid saponin biosynthesis

description: Additional file 4: Table S2. List of 150 CYP450s of A. elata identified in this study.
DOI: 10.6084/m9.figshare.12299363.v1
title: Additional file 4 of Identification and analysis of CYP450 and UGT supergene family members from the transcriptome of Aralia elata (Miq.) seem reveal candidate genes for triterpenoid saponin biosynthesis

description: Additional file 4: Table S2. List of 150 CYP450s of A. elata identified in this study.
DOI: 10.6084/m9.figshare.12299369
title: Additional file 5 of Identification and analysis of CYP450 and UGT supergene family members from the transcriptome of Aralia elata (Miq.) seem reveal candidate genes for triterpenoid saponin biosynthesis

description: Additional file 5: Table S3. List of 92 UGTs of A. elata identified in this study.
DOI: 10.6084/m9.figshare.14396535
title: Additional file 6 of Gene expression and immune infiltration in melanoma patients with different mutation burden

description: Additional file 6: Table S1-S7.
DOI: 10.6084/m9.figshare.23849546
title: Additional file 2 of Presence and role of viruses in anaerobic digestion of food waste under environmental variability

description: Additional file 2.
DOI: 10.6084/m9.figshare.23849546.v1
title: Additional file 2 of Presence and role of viruses in anaerobic digestion of food waste under environmental variability

description: Additional file 2.
DOI: 10.6084/m9.figshare.14920809
title: Additional file 1 of Amiloride ameliorates muscle wasting in cancer cachexia through inhibiting tumor-derived exosome release

description: Additional file 1: Supplementary Fig. S1-S15 and Tables S1-S5.
DOI: 10.6084/m9.figshare.14920812.v1
title: Additional file 2 of Amiloride ameliorates muscle wasting in cancer cachexia through inhibiting tumor-derived exosome release

description: Additional file 2: The DEGs identified in the transcriptomics study.
DOI: 10.6084/m9.figshare.14385237.v1
title: Additional file 1 of The prognosis of recurrent low-grade endometrial stromal sarcoma: a retrospective cohort study

description: Additional file 1. Raw data of this study.
DOI: 10.6084/m9.figshare.14920875
title: Additional file 4 of Transcriptome analysis of five ovarian stages reveals gonad maturation in female Macrobrachium nipponense

description: Additional file 4:
DOI: 10.6084/m9.figshare.14920875.v1
title: Additional file 4 of Transcriptome analysis of five ovarian stages reveals gonad maturation in female Macrobrachium nipponense

description: Additional file 4:
DOI: 10.6084/m9.figshare.13347959.v1
title: Microwave ablation shows similar survival outcomes compared with surgical resection for hepatocellular carcinoma between 3 and 5 cm

description: Microwave ablation (MWA) is a safe and effective locoregional ablation modality, but it is not clear whether the curative effect of MWA as to hepatocellular carcinoma (HCC) is comparable to that of surgical resection (SR). We aimed to compare the outcomes of MWA and SR for patients with HCC ranging from 3 to 5 cm. 197 patients treated for HCC between 3 and 5 cm by MWA or SR were included from 2010 to 2017. Overall survival (OS), progression-free survival (PFS), complication and hospital stay of those patients were compared by using propensity score matching. The registration number of this clinical trial was ChiCTR2000033983. For patients with HCC between 3 and 5 cm, the 1-, 3-, and 5- years OS rates were 90.3%, 79.7%, and 65.5% in the MWA group, and 96.7%, 88.6%, and 71%% in the SR group, respectively (<i>p</i> = 0.457). The 1-, 3- and 5- years PFS rates were 63.6%, 36.8% and 32.7% in the MWA group, and 74.2%, 41.9% and 35.5% in the SR group, respectively (<i>p</i> = 0.397). The MWA group showed fewer complications (55% versus 78.8%, <i>p</i> = 0.041) and shorter hospital stays (8 versus 15 days, <i>p</i> &lt; 0.001) compared with the SR group. MWA showed similar survival outcomes compared with SR for HCCs ranging from 3 to 5 cm. However, it showed favorable results in terms of hospital stay and complication rate compared to SR.
DOI: 10.6084/m9.figshare.14396535.v1
title: Additional file 6 of Gene expression and immune infiltration in melanoma patients with different mutation burden

description: Additional file 6: Table S1-S7.
DOI: 10.6084/m9.figshare.13348082.v1
title: Methylomic Signatures of High Grade Serous Ovarian Cancer

description: High-grade serous ovarian cancer (HGSOC) harbours aberrant epigenetic features, including DNA methylation. In this study we delineate pathways and networks altered by DNA methylation and associated with HGSOC initiation and progression to a platinum-resistant state. By including tumours from patients who had been treated with the hypomethylating agent (HMA) guadecitabine, we also addressed the role of HMAs in treatment of HGSOC. Tumours from patients with primary (platinum-naïve) HGSOC (n = 20) were compared to patients with recurrent platinum-resistant HGSOC and enrolled in a recently completed clinical trial (NCT01696032). Human ovarian surface epithelial cells (HOSE; n = 5 samples) served as normal controls. Genome-wide methylation profiles were determined. DNA methyltransferase (DNMT) expression levels were examined by immunohistochemistry and correlated with clinical outcomes. Cancer-related and tumorigenesis networks were enriched among differentially methylated genes (DMGs) in primary OC vs. HOSE. When comparing platinum-resistant and primary tumours, 452 CpG island (CGI)-containing gene promoters acquired DNA methylation; of those loci, decreased (P &lt; 0.01) methylation after HMA treatment was observed in 42% (n = 189 CGI). Stem cell pluripotency and cytokine networks were enriched in recurrent platinum-resistant OC tumours, while drug metabolism and transport-related networks were downregulated in tumours from HMA-treated patients compared to HOSE. Lower DNMT1 and 3B protein levels in pre-treatment tumours were associated with improved progression-free survival. The findings provide important insight into the DNA methylation landscape of HGSOC tumorigenesis, platinum resistance and epigenetic resensitization. Epigenetic reprogramming plays an important role in HGSOC aetiology and contributes to clinical outcomes.
DOI: 10.6084/m9.figshare.20163839
title: Analysing climatic variability and extremes events in the Himalayan regions focusing on mountainous urban agglomerations

description: The present study highlights the long-term variations in temperature and precipitation using time series datasets of CRU and ERA5-Land across the Himalayan region. The Mann-Kendall and Sen’s slope-based trend analysis exhibited an apparent warming trend in the region, with higher increase in Tmin (1.5 °C) and comparatively lower increase in Tmax (0.8 °C) during 1901–2018. The joint CCl/WCRP/JCOMM based 19 extreme indices elucidated an increasing frequency of warm days (16%) in Central Himalayan urban agglomerations (HUAs) with a declining number of cold days (−6%) and cold nights (−4%) during 2000–2019. The moderate decline in the wet days (8%) and consecutive wet days (−5 days/20 years) observed in all HUAs compared to an increasing frequency of the consecutive dry days (3 days/20 years). Study reported higher warming in Kathmandu UA, while increased precipitation in Srinagar UA, and contributes to framing climate change adaptation and mitigation strategies in the mountainous system.
DOI: 10.6084/m9.figshare.7580936
title: Additional file 2 of Decrease of gene expression diversity during domestication of animals and plants

description: Table S8. provides the mapping information for the seven pairs. Table S9. provides information about the resequencing data for rice. Table S10. provides the candidate selected genes for rice. Table S11. presents the expression diversity of the seven pairs. (XLSX 149 kb)
DOI: 10.6084/m9.figshare.11791191
title: Low-temperature NO reduction performance of peanut shell-derived few-layer graphene loaded CeCo<sub>x</sub>Mn<sub>1-x</sub>O<sub>3</sub> catalyst

description: The catalysts were prepared by the hydrothermal method using agricultural waste biomass peanut shell-derived few-layer graphene (PS-FLG) as the support. The NO reduction performance test of NH<sub>3</sub>-SCR and various characterization means were employed to preliminarily explore the mechanism of Co-doping activity at the B site. The results showed that the conversion rate of NO<sub>x</sub> of the three catalysts reached 99.1% and remained stable in the range of 250 ∼ 400 °C. The order of activity at low temperature was 5% CeCo<sub>0.5</sub>Mn<sub>0.5</sub>O<sub>3</sub> &gt; 5% CeMnO<sub>3</sub> &gt; 5% CeCoO<sub>3</sub>. Partial doping of Co could inhibit the aggregation of active components, increase the percentage of high valence ions, improve the migration of lattice oxygen (O<sub>β</sub>) to the adsorbed oxygen (O<sub>α</sub>), and enhance the redox performance. CeCo<sub>0.5</sub>Mn<sub>0.5</sub>O<sub>3</sub> exhibited better low-temperature activity, and the conversion rate of NO<sub>x</sub> reached 97.0% at 200 °C, and had excellent SO<sub>2</sub> resistance.
DOI: 10.6084/m9.figshare.19131248
title: High-moisture Extrusion Technology Application in the Processing of Textured Plant Protein Meat Analogues: A Review

description: The development of meat alternatives is a sustainable choice to meet eco-friendly and healthy demands. High-moisture extrusion (HME) technology has been applied to produce the textured plant proteins, which are recognized as meat analogues and have characteristics, nutrition, sensory attributes, and apparent fiber structure similar to animal meat. Although the production of HME meat analogues has a lot of advantages and broad prospects, the processing principle and quality control remain to be studied, and the current HME technology has not yet been popularized. In this paper, we review the HME technology, the formation mechanism of HME meat analogues, the effect of food ingredients on meat analogues processing, the systematic analysis method of meat analogues processing, and detection and evaluation methods of meat analogues. Our review would provide a comprehensive understanding and theoretical guidance for HME application in meat analogues processing.
DOI: 10.6084/m9.figshare.19131248.v1
title: High-moisture Extrusion Technology Application in the Processing of Textured Plant Protein Meat Analogues: A Review

description: The development of meat alternatives is a sustainable choice to meet eco-friendly and healthy demands. High-moisture extrusion (HME) technology has been applied to produce the textured plant proteins, which are recognized as meat analogues and have characteristics, nutrition, sensory attributes, and apparent fiber structure similar to animal meat. Although the production of HME meat analogues has a lot of advantages and broad prospects, the processing principle and quality control remain to be studied, and the current HME technology has not yet been popularized. In this paper, we review the HME technology, the formation mechanism of HME meat analogues, the effect of food ingredients on meat analogues processing, the systematic analysis method of meat analogues processing, and detection and evaluation methods of meat analogues. Our review would provide a comprehensive understanding and theoretical guidance for HME application in meat analogues processing.
DOI: 10.6084/m9.figshare.22277034
title: Two-Directional Simultaneous Inference for High-Dimensional Models

description: This article proposes a general two-directional simultaneous inference (TOSI) framework for high-dimensional models with a manifest variable or latent variable structure, for example, high-dimensional mean models, high-dimensional sparse regression models, and high-dimensional latent factors models. TOSI performs simultaneous inference on a set of parameters from two directions, one to test whether the assumed zero parameters indeed are zeros and one to test whether exist zeros in the parameter set of nonzeros. As a result, we can better identify whether the parameters are zeros, thereby keeping the data structure fully and parsimoniously expressed. We theoretically prove that the single-split TOSI is asymptotically unbiased and the multi-split version of TOSI can control the Type I error below the prespecified significance level. Simulations are conducted to examine the performance of the proposed method in finite sample situations and two real datasets are analyzed. The results show that the TOSI method can provide more predictive and more interpretable estimators than existing methods.
DOI: 10.6084/m9.figshare.22277034.v3
title: Two-Directional Simultaneous Inference for High-Dimensional Models

description: This article proposes a general two-directional simultaneous inference (TOSI) framework for high-dimensional models with a manifest variable or latent variable structure, for example, high-dimensional mean models, high-dimensional sparse regression models, and high-dimensional latent factors models. TOSI performs simultaneous inference on a set of parameters from two directions, one to test whether the assumed zero parameters indeed are zeros and one to test whether exist zeros in the parameter set of nonzeros. As a result, we can better identify whether the parameters are zeros, thereby keeping the data structure fully and parsimoniously expressed. We theoretically prove that the single-split TOSI is asymptotically unbiased and the multi-split version of TOSI can control the Type I error below the prespecified significance level. Simulations are conducted to examine the performance of the proposed method in finite sample situations and two real datasets are analyzed. The results show that the TOSI method can provide more predictive and more interpretable estimators than existing methods.
DOI: 10.6084/m9.figshare.11267015
title: Tai Chi exercise and functional electrical stimulation of lower limb muscles for rehabilitation in older adults with chronic systolic heart failure: a non-randomized clinical trial

description: Exercise-based training decreases hospitalizations in heart failure patients but such patients have exercise intolerance. The objectives of the study were to evaluate the effect of 12 weeks of Tai Chi exercise and lower limb muscles' functional electrical stimulation in older chronic heart failure adults. A total of 1,084 older adults with chronic systolic heart failure were included in a non-randomized clinical trial (n=271 per group). The control group did not receive any kind of intervention, one group received functional electrical stimulation of lower limb muscles (FES group), another group practiced Tai Chi exercise (TCE group), and another received functional electrical stimulation of lower limb muscles and practiced Tai Chi exercise (FES & TCE group). Quality of life and cardiorespiratory functions of all patients were evaluated. Compared to the control group, only FES group had increased Kansas City Cardiomyopathy Questionnaire (KCCQ) score (P&lt;0.0001, q=9.06), only the TCE group had decreased heart rate (P&lt;0.0001, q=5.72), and decreased peak oxygen consumption was reported in the TCE group (P&lt;0.0001, q=9.15) and FES & TCE group (P&lt;0.0001, q=10.69). FES of lower limb muscles and Tai Chi exercise can recover the quality of life and cardiorespiratory functions of older chronic heart failure adults (trial registration: Research Registry 4474, January 1, 2015).
DOI: 10.6084/m9.figshare.11267015.v1
title: Tai Chi exercise and functional electrical stimulation of lower limb muscles for rehabilitation in older adults with chronic systolic heart failure: a non-randomized clinical trial

description: Exercise-based training decreases hospitalizations in heart failure patients but such patients have exercise intolerance. The objectives of the study were to evaluate the effect of 12 weeks of Tai Chi exercise and lower limb muscles' functional electrical stimulation in older chronic heart failure adults. A total of 1,084 older adults with chronic systolic heart failure were included in a non-randomized clinical trial (n=271 per group). The control group did not receive any kind of intervention, one group received functional electrical stimulation of lower limb muscles (FES group), another group practiced Tai Chi exercise (TCE group), and another received functional electrical stimulation of lower limb muscles and practiced Tai Chi exercise (FES & TCE group). Quality of life and cardiorespiratory functions of all patients were evaluated. Compared to the control group, only FES group had increased Kansas City Cardiomyopathy Questionnaire (KCCQ) score (P&lt;0.0001, q=9.06), only the TCE group had decreased heart rate (P&lt;0.0001, q=5.72), and decreased peak oxygen consumption was reported in the TCE group (P&lt;0.0001, q=9.15) and FES & TCE group (P&lt;0.0001, q=10.69). FES of lower limb muscles and Tai Chi exercise can recover the quality of life and cardiorespiratory functions of older chronic heart failure adults (trial registration: Research Registry 4474, January 1, 2015).
DOI: 10.6084/m9.figshare.22277148
title: Optimal timing and drug combination of selinexor in multiple myeloma: a systematic review and meta-analysis

description: Multiple myeloma (MM) remains an incurable disease despite advances in treatment options. Recently, selinexor has shown promising efficacy for relapsed/refractory multiple myeloma (RRMM), whereas its optimal timing and drug combination remain unclear. In order to assess the various regimens that incorporate selinexor, a systematic review and meta-analysis was conducted. Clinical trials and real-world studies involving MM patients treated with selinexor were included. Pooled risk ratio (RR) was calculated to compare the rates, along with a 95% confidence interval (CI) and concurrent <i>p</i>-value assessment. A random-effects model was employed to provide a more conservative evaluation. A total of 16 studies enrolling 817 patients were reviewed. The usage of selinexor as the fifth-line or prior therapy achieved a higher objective response rate (ORR) (65.9% versus 23.4%, <i>p </i>&lt; 0.01) and longer pooled progression-free survival (PFS) (median: 12.5 months versus 2.9 months, <i>p </i>&lt; 0.01) than those after the fifth-line usage. In addition, early usage also resulted in a consistent trend of pooled overall survival (median: 22.7 months versus 8.9 months, <i>p </i>= 0.26), compared with post-fifth-line usage. Selinexor and dexamethasone (Xd) plus either protease inhibitors (PIs) or immunomodulatory drugs (IMiDs) achieved better ORRs than the Xd-only regimen for RRMM, with ORRs of 56.1%, 52.5% and 24.6%, respectively (<i>p </i>&lt; 0.01). In conclusion, using selinexor as the fifth-line or prior therapy had a beneficial impact on RRMM. The regimen of Xd plus PIs or IMiDs was recommended.
DOI: 10.6084/m9.figshare.25140689
title: all_editors_jounals_final.csv

description: This dataset presents a comprehensive portrait of the editorship phenomenon in Innovation Studies by probing the structural features of the boards of 20 leading innovation-oriented journals as of 2019.