cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.13145/bacdive125091.20191129.4.1
title: Streptomyces sp.

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.14457/cu.the.2017.284
title: Effects of genistein on oxidative stress and inflammation in acute pancreatitis mice

description: Genistein (GEN), the most abundant isoflavones in soy, has similar structure to human estradiol. It has been reported the potent properties of GEN on antioxidant and anti-inflammation. The aim of this study was to investigate the effects of GEN on oxidative stress, inflammatory, and histopathology in acute pancreatitis induced by L-arginine in mice. Male ICR mice were randomly divided into 4 groups (6 mice in each group). Control (Con) group: mice were injected with 2% dimethyl sulfoxide (DMSO) once daily for 4 days, via IP. Acute pancreatitis (AP) group: mice were injected 2 times (1 hour interval) of 350 mg/100 g body weight L-arginine which dissolved in 0.9% normal saline to induce acute pancreatitis. AP + low dose genistein (LG) group: mice were received 10 mg/kg GEN, while AP + high dose GEN (HG) group: mice were received 100 mg/kg GEN, dissolved in 2% DMSO administered by IP injection 2 hours before the induction of L-arginine, then daily injection of GEN for 3 days. Body weight change was compared between at the beginning and the end of study. Serum and pancreas were collected 72 hours after induction of L- arg. The result showed that, low and high doses of genistein were able to attenuate severity of acute pancreatitis which characterized by restored body weight loss, decreased serum AMY, inflammatory cytokines (IL-6, CPR, and MPO), pancreatic MDA, and decreased histological damage. In the present study increased understanding of the effects of genistein on oxidative stress, inflammation as well as pancreatic histopathology in L-arg induced acute pancreatitis mice.
DOI: 10.13145/bacdive125092.20191129.4.1
title: Streptomyces sp.

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.13145/bacdive125093.20191129.4.1
title: Streptomyces sp.

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.14457/cu.the.2017.285
title: Doxorubicin-conjugated dexamethasone induced MCF-7 apoptosis without entering the nucleus and able to overcome MDR-1-induced resistance

description: Doxorubicin is a common chemotherapeutic drug that generally uses in many solid and hematologic malignancies. The main mechanism of doxorubicin is inhibition of topoisomerase II that occurs in the nucleus. Currently, doxorubicin resistant cancer cells which have decreased accumulation of intracellular doxorubicin resulting from an efflux pump, P-glycoprotein encoded by multidrug resistant gene. Several studies reported many different ways to overcome doxorubicin resistance. In this study, we conjugated 3’amino group of doxorubicin to dexamethasone molecule. Despite of lower cytotoxic activity in MCF-7 cells, the conjugated product, DexDOX, exerted its actions in the different fashion to doxorubicin. DexDOX rapidly induced MCF-7 cells apoptosis without entering to the nucleus. Further analysis showed that DexDOX increased cytosolic oxidative stress and did not interfere with cell cycle. In addition, DexDOX retained cytotoxicity in MDR-1 over-expressed MCF-7 cells which had ≈16-folds resistance to doxorubicin. We here synthesized a new derivative of doxorubicin, DexDOX, which can overcome MDR-1 induced resistant. This molecule might be useful for future therapy.
DOI: 10.13145/bacdive125094.20191129.4.1
title: Streptomyces sp.

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.14457/cu.the.2017.286
title: CADAVERIC EVALUATION OF THE LOCATION OF ARTERIES AND THEIR ANASTOMOTIC TERRITORIES ON THE FACE: THE FEASIBILITY DETERMINATION OF RISKY SEVERE COMPLICATIONS REGARDING TO THE FILLER INJECTIONS SITES

description: The facial aging features are most concerns; therefore, the filler injection procedures are selected to provide the youthful face. However, the several complications following arterial devastating have been reported continually. Therefore, this study objectively evaluated the arterial location relative to filler injection sites. Furthermore, the arterial anastomoses and arterial supply of each injection site were also studied to verify the filler embolic pathways. This dissection was performed on 62 hemi-faces Thai embalmed cadavers to investigate nearest artery and its location of all injection sites. While, the 20 hemi-faces Thai embalmed cadavers were employed with Sihler’s staining procedure to examine the anastomotic pathways. The most of nearest artery of forehead landmark was supratrochlear artery (48.4%). For the eyebrow injection site, the most nearest artery was brow branch of supraorbital artery (46.8%). The most nearest artery was lateral rim branch (35.5%) at upper eyelid injection site. At the glabellar area, the main nearest artery was left central artery (32.3%). For the temple injection sites, the closest artery was descending branch of superficial temporal artery (50.0%). At the tear trough, the major nearest artery was angular branch of ophthalmic artery (43.5%). Moreover, the main nearest artery to mid cheek was infraorbital artery (29.0%), whereas transverse facial artery was locating nearest to lateral hollowness injection site. However, facial artery located nearest to nasolabial injection sites (58.1%). The superior labial artery was found mostly locating closest to upper lip injection sites (88.7%). The closest artery to chin and jawline injection sites was right submental (61.3%) and facial artery (88.7%), respectively. To summarize our finding, the upper face may provide highest risk of severe complications when compares with the middle and lower face regions. However, the middle face may confront with the risk of severe complication due to it has anastomosis to the branch of ophthalmic artery.
DOI: 10.13145/bacdive125095.20191129.4.1
title: Streptomyces sp.

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.14457/cu.the.2017.287
title: Histopathologic difference between sinonasal mucosa and polyp tissue for diagnosing eosinophilic chronic rhinosinusitis

description: This study aims to assess the appropriate site for diagnosing eosinophilic chronic rhinosinusitis (ECRS) by histopathology. Patients with chronic rhinosinusitis with polyps (CRSwNP) were enrolled. Specimens were collected from polyp apex, polyp pedicle, polyp scraping and ethmoid mucosa. Number of tissue eosinophil of the four samples was assessed with intrapersonal comparison for diagnosing ECRS. Correlations with clinical characteristics of ECRS were assessed for each site. Results showed that thirty patients with CRSwNP were enrolled. Polyp apex, polyp pedicle and ethmoid mucosa gave similar results for diagnosing ECRS in 16 patients (53.3%). Median tissue eosinophil was greater in polyp apex (84, IQR: 34-194) and polyp pedicle (96, IQR: 80-320) than ethmoid mucosa (21, IQR: 10-220), p=0.04. Sensitivity for diagnosing ECRS were 100% (95%CI: 47.8 - 100) for polyp apex, 60% (95%CI: 14.7 - 94.7) for polyp pedicle, 80% (95%CI: 28.4 – 99.5) for ethmoid mucosa. Correlations with asthma were significant for polyp pedicle (p=0.05), and ethmoid mucosa (p=0.04) but not polyp apex (p=0.21). Correlations with serum eosinophilia, and eosinophilic mucin were not significant. Tissue eosinophil from polyp scraping only correlated with ehtmoid mucosa. Consequently, density of tissue eosinophil was greater in nasal polyp than ethmoid mucosa. Polyp apex had greater sensitivity for diagnosing ECRS than others. Polyp pedicle and ethmoid mucosa correlated with asthma. Tissue eosinophil from polyp scraping only correlated with ehtmoid mucosa.
DOI: 10.13145/bacdive125096.20191129.4.1
title: Streptomyces sp.

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.13145/bacdive125097.20191129.4.1
title: Streptomyces sp.

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.14457/cu.the.2017.288
title: RADIATION DOSE AND IMAGE QUALITY IN CHEST REGION USING SINGLE- AND DUAL-ENERGY CT: PHANTOM STUDY

description: Chest CT examinations are routinely performed by using single energy protocol (SE). As CT had been evolved by using dual energy protocol (DE), the patients with underlying lung nodules or pulmonary nodules will be followed up by CT examination several times. The purpose of this study is to study the radiation dose and image quality between single-energy CT (SECT) and dual-energy CT (DECT) protocols in chest phantom at King Chulalongkorn Memorial Hospital. The Lungman Kyoto Kagaku phantom inserted by five simulated lesions of various diameters was scanned by dual-source CT system (Somatom Force, Siemens Healthineers). The acquisition protocols consist of single-energy and dual-energy modes with varied tube potential. Radiation dose is determined in terms of CTDI volume (CTDIvol), Dose Length Product (DLP) and effective dose. Image noise, CNR and lesion detectability are the image quality indicators in this study. The results of this study show that the mean value of radiation dose in SE at 120 kVp was highest among all acquisition protocols, which results in lower image noise than DE. CNR of DE at 100/Sn150 kVp was greater than 120 kVp, all SE protocols, DE at 80/Sn150 and 90/Sn150. Regarding lesion detectability, in the soft tissue window, the simulated lesions were detected by the observers in dual energy mode as similar to in single-energy mode at 120 kVp. Moreover, in the lung window, all observers can detect the simulated lesions better than in soft tissue window, which results in five lesions were detected in both single- and dual- energy protocols, the same as CT lung CAD software could detect five simulated lesions. Therefore, DECT offers an alternative protocol for lung nodule detection because DECT offer lower radiation dose than SECT (120 kVp), clinical protocol in chest CT examination, in addition to lesion detectability DECT is similar to 120 kVp. In contrast, the image noise of DECT is higher than 120 kVp that affect the interpretation of radiologist. Therefore, DE protocols can be selected under the justification of qualified CT radiologist with the optimal protocol in chest CT examination.
DOI: 10.13145/bacdive125098.20191129.4.1
title: Streptomyces sp.

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.13145/bacdive125099.20191129.4.1
title: Streptomyces sp.

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.14457/cu.the.2017.289
title: CT NUMBER AND ELECTRON DENSITY RELATIONSHIP FOR PHOTON DOSE CALCULATION IN HEAD AND NECK, CHEST, SPINE AND PELVIC REGIONS

description: CT images supply the HU information that relates to electron density (ρe). The ρe is important for tissue inhomogeneity correction for accurate dose calculation. The purpose of this study was to evaluate the dosimetric effect on CT images on different kVp setting using single HU-ρe curve. Anthropomorphic phantom was scanned using Siemens-SOMATOM Definition AS with 120 kVp setting and used as a reference image set. The procedures were repeated with DECT option (80/140 kVp), 80 and 140 kVp. The 120 kVp HU-ρe relationship curve from Gammex 467 tissue characterization phantom was created and applied into Eclipse treatment planning system. The five clinical plans in each 3D, IMRT and VMAT techniques in four regions (head and neck, chest, spine and pelvic regions) were exported and recalculated in Anthropomorphic phantom images for all kVp setting images. Moreover, the amalgam was inserted in Anthropomorphic phantom at teeth location and the radiation dose in head and neck region was evaluated. The isocenter dose and gamma index from SNC patient software with criteria 1%/1mm. (γ1%/1mm.) were selected for plan evaluation. According to treatment regions, the average point dose differences of DECT, 80 and 140 kVp images to reference image were 0.7%, 0.4% and 0.3% for H&N, 0.5%, 0.3% and 0.2% for chest, 0.6%, 0.5% and 0.1% for spine, 0.9%, 0.2% and 0.2% for pelvic region and 0.1%, 0.4% and 0.1% for H&N with amalgam, respectively. For gamma index, the average γ1%/1mm. passing rate in all regions and all techniques of DECT, 80 and 140 kVp images were 95.9%, 100% and 100%, respectively. From the results, the different kVp images gave the different HU value and it has impacted to dose distribution. The results of isocenter dose differences showed the good agreement with gamma index results. DECT images presented the highest average dose differences from other energies, especially in large area of high density. Pelvic region displayed the highest average dose differences than other regions because it consists of the large bone area in pelvic bone. IMRT and VMAT technique showed the highest average dose difference that might be due to the high MU and complicated leaf movements. In conclusion, it is possible to apply single 120 kVp HU-ρe relationship curve into all tube voltage scanning images with the highest average point dose difference of 0.6% in DECT and lowest average γ1%/1mm. passing rate of 95.9%.
DOI: 10.13145/bacdive125100.20191129.4.1
title: Streptomyces sp.

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.14457/cu.the.2017.290
title: THE DETERMINATION OF OPTIMAL PROTOCOL FOR DIGITAL CHEST TOMOSYNTHESIS

description: Recently, digital chest tomosynthesis (DTS) is introduced as alternative technique in digital chest radiography for evaluating pulmonary disease and enhancing the internal structures in different slices. However, the radiation dose is higher compared to general chest radiography. The present study was to determine the optimal protocol for DTS in order to reduce the radiation dose to patients while maintaining the image quality. The multipurpose chest phantom N1 "LUNGMAN’’ was scanned by digital radiographic systems model Definium 8000.Such phantom was inserted with simulated nodules with size diameter of 3, 5, 8, 10, 12 mm, and the data were acquired using chest VolumeRAD protocol with AEC technique. Parameters were varied in tube voltage (100, 110, 120 kVp) copper filter (0.0, 0.1, 0.2, 0.3 mm) and dose ratio (1:5, 1:8, 1:10) for evaluating the optimal protocol. All of protocols were performed three times. The entrance surface dose (ESD) was measured using glass dosimeter attached at the mid-chest level of the phantom. The effective dose (ED) was calculated using the recorded DAP value. The signal-to-noise ratio (SNR) was measured for qualitative image quality evaluation. The image criteria and nodule detection capability were scored by two experienced radiologists. The results indicated that the average±SD of ESD obtained from vendor’s default protocol at 120 kVp, dose ratio 1:10 and no copper filter was 1.68±0.15 mGy. The optimal parameter for DTS was obtained at 110 kVp, dose ratio 1:5, and copper filter at 0.3 mm with the ESD of 0.47±0.02 mGy. The effective doses for the default protocol and optimal protocol were 313.98±0.72 µSv and 100.55±0.28 µSv, respectively. There were slightly different of the image criteria and nodule detection between optimal and default protocols using visual assessment by two radiologists. In the clinical study, the average patient’s thickness of 22.51±1.70 cm (range 19.30-25.80 cm) was obtained. The average±SD effective dose of 98.87±0.08 µSv was obtained after applied the optimal protocol in 30 patients. The dose ratio and tube voltage were in slightly correlation with the radiation dose since the AEC technique was applied. A copper filter has a potential to reduce radiation dose to the patients. In conclusion, the optimal protocol can reduce radiation dose substantially while preserving the image quality compared to the vendor default protocol.
DOI: 10.13145/bacdive125101.20191129.4.1
title: Streptomyces sp.

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.13145/bacdive125102.20191129.4.1
title: Streptomyces sp.

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.14457/cu.the.2017.291
title: THE DOSIMETRIC EVALUATION ON PHOTON ENERGY EFFECT FOR CERVICAL CARCINOMA IN 3D-CRT, IMRT, AND VMAT PLANS

description: In the previous time, 3D-CRT technique has been considered as the primary treatment for cervical cancer treatment. Nowadays, advanced techniques, IMRT and VMAT, are used to treat because of the dosimetric and clinical benefit over 3D-CRT technique. However, each of these technique generates difference outcomes. The purpose of this study was to investigate the dosimetric outcomes between 6 and 15 MV photon energies in each 4 fields box 3D-CRT, 9 fields IMRT, and 2 arcs VMAT plans of five advanced cervical cancers using parameters of D95%, TC, HI, CI, CN from PTV, V45 Gy and V50 Gy from OARs, NTID, MUs, beam on time, neutron dose as well as gamma dose contamination. The plans were performed on Eclipse TPS with the prescribed dose of 50.4 Gy/28F. The results showed that PTV received dose at least 50.4 Gy for all energies and techniques, while the OARs doses were lower than the tolerance limits except 3D-CRT technique. The IMRT and VMAT techniques showed the great similar PTV and OARs doses in both energy plans. The two energy IMRT and VMAT plans revealed percent volume of bladder, rectum and bowel reside in tolerance limit. However, the NTID, Mus, and beam on time in the 15 MV of all planning techniques provided better results than 6 MV plans. For radiation contamination during irradiation, the 15 MV plans presented the higher neutron dose in IMRT than 3D-CRT and VMAT, respectively due to the influence of gantry directions. While at 30s, 2mins, and 5mins after irradiation, the results were different because the outcomes relate to MUs results. Therefore, the neutron and gamma dose of VMAT were higher than 3D-CRT technique whereas IMRT delivered the highest neutron and gamma dose contamination. In conclusion, the 15 MV is recommended in 3D-CRT due to the better in CI and CN property. In contrast, the 6 MV energy is a good option for IMRT technique, since the same dosimetric parameters but 15 MV beams present neutron and gamma dose. For VMAT technique, both of photon energies are suitable to treat cervical cancer due to no significant difference in almost all outcome parameters between these two energies.
DOI: 10.13145/bacdive125103.20191129.4.1
title: Streptomyces sp.

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.13145/bacdive125104.20191129.4.1
title: Streptomyces sp.

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.14457/cu.the.2017.292
title: MEASUREMENT OF EYE LENS DOSE IN INTERVENTIONAL RADIOLOGIST FROM TACE PROCEDURES USING OSLD

description: For routine clinical service at Section of Interventional Radiology, Department of Radiology, King Chulalongkorn Memorial Hospital (KCMH), TACE procedure has been one of the high exposure procedures, which result in increasing eye lens dose in interventional radiologists. Thus, radiation dose should be evaluated in interventional radiology staff who may receive high eye lens dose. Currently, there is insufficient information to comply with the ICRP dose limit on the occupation exposure to the eye lens. One of the factors affecting the eye lens dose is the variation in tube directions in the interventional radiology (IR) laboratories. A preliminary study about tube angulations influence radiation exposure to the eye lens has been conducted. The objectives of this study are to determine the average annual equivalent doses and the parameters influence equivalent doses to the eye lens of the interventional radiologists in TACE procedures at King Chulalongkorn Memorial Hospital. In order to determine the average annual eye lens dose of an interventional radiologist and three fellows, four nanoDot (OSL) dosimeters were taped on the left and right sides of the inside and outside of lead glass eyewear and measured monthly. The annual eye lens doses were then estimated. The influence of tube angulation to the eye lens dose had been studied using Toshiba digital flat-panel angiographic system (Infinix-I 8000C) and nanoDot dosimeters taped on the lead glass eyewear which applied to the rando phantom to simulate the interventional radiologist under TACE procedure. The results show the average annual eye lens dose measured from an interventional radiologist and three fellows at left side was 7.64 mSv and at the right side was 6.21 mSv when the lead glass eyewear was applied. The maximum estimated annual dose at the left and right eyes without lead glasses were 31.96 and 24.23 mSv respectively. Tube direction under LAO combined with caudal angle delivered the highest eye lens dose of 9.20 mSv/procedure at the left eye when protective equipment was not utilized. The eye lens dose at the right side inside the lead glass eyewear was higher than outside in two fellows as some scattered radiation can reach the right nanoDot inside lead glasses without reaching the outside dosimeter. Radiation exposure from LAO series was high due to the shorter distance between the source of scattered radiation and the phantom than the other tube directions. The annual eye lens dose of the interventional radiologist has the potential to exceed the new ICRP dose limit of 20 mSv/year if radiation protective tools are not properly used.
DOI: 10.13145/bacdive125105.20191129.4.1
title: Streptomyces sp.

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.