cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.5666197
title: Low cost system to measure active power in electrosurgical units

description: Abstract Introduction: The real-time measurement of active power delivered to patients during the electrosurgical act is still an engineering challenge. Besides, there is no electrosurgical unit on the market capable of doing it according to the normative requirement. Methods This work presents the design of an electronic structure capable to probe the electrosurgical equipment output electrical signals, using low-costs very common resistors, and High Frequency distortions compensation circuits, and process them to provide an analogue signal proportional to the active power, allowing the knowledge and control of the energy delivered to the biological tissue. The reading circuits and the active power calculation method are presented. The power calculation is performed in two stages. The first one consists of a multiplier circuit that uses the readings voltage and current quantities to determine the instantaneous output power, and the second stage is formed by an integrating circuit which determines the average power value, resulting in a rippled continuous voltage, proportional to the active power delivered to the patient or biological tissue. Results Practical tests of the compensation technical are statistically evaluated by means of linear regressions. Results of 23 tests are summarized in a way to demonstrate de effectiveness of the proposed system. Conclusion Analysis of the results demonstrate the efficiency of the proposed system, whose average error is lower than 5%, and correlating them with the standard IEC 60601-2-2, that regulates the operation of electrosurgery units.
DOI: 10.6084/m9.figshare.5666197.v1
title: Low cost system to measure active power in electrosurgical units

description: Abstract Introduction: The real-time measurement of active power delivered to patients during the electrosurgical act is still an engineering challenge. Besides, there is no electrosurgical unit on the market capable of doing it according to the normative requirement. Methods This work presents the design of an electronic structure capable to probe the electrosurgical equipment output electrical signals, using low-costs very common resistors, and High Frequency distortions compensation circuits, and process them to provide an analogue signal proportional to the active power, allowing the knowledge and control of the energy delivered to the biological tissue. The reading circuits and the active power calculation method are presented. The power calculation is performed in two stages. The first one consists of a multiplier circuit that uses the readings voltage and current quantities to determine the instantaneous output power, and the second stage is formed by an integrating circuit which determines the average power value, resulting in a rippled continuous voltage, proportional to the active power delivered to the patient or biological tissue. Results Practical tests of the compensation technical are statistically evaluated by means of linear regressions. Results of 23 tests are summarized in a way to demonstrate de effectiveness of the proposed system. Conclusion Analysis of the results demonstrate the efficiency of the proposed system, whose average error is lower than 5%, and correlating them with the standard IEC 60601-2-2, that regulates the operation of electrosurgery units.
DOI: 10.6084/m9.figshare.5666194
title: Surface Charge Density Determination in Water Based Magnetic Colloids: a Comparative Study

description: This work focuses on the systematic investigation of the two well-established methods of structural surface charge density determination on magnetic colloids, labeled as Single Potentiometric Method (SPM) and Potentiometric-Conductometric Method (PCM). To compare some important features of the methods we determined the structural surface charge density of magnetic colloids samples based on CoFe2O4@ɣ-Fe2O3 core-shell nanoparticles with three different mean sizes using both strategies. Concerning quickness, easiness and cost, the PCM has proved to be more advantageous than the SPM. Regarding the effectiveness, both methods were consistent in determining the saturation value of the structural charge, but the SPM was more accurate to describe the pH-dependence of the concentration of the charged surface sites. Considering the chemical safety, the methods are equivalent. Finally, both the SPM and PCM are reproducible and can be effectively applied to determine the saturation value of the surface charge density on magnetic colloids.
DOI: 10.6084/m9.figshare.5666194.v1
title: Surface Charge Density Determination in Water Based Magnetic Colloids: a Comparative Study

description: This work focuses on the systematic investigation of the two well-established methods of structural surface charge density determination on magnetic colloids, labeled as Single Potentiometric Method (SPM) and Potentiometric-Conductometric Method (PCM). To compare some important features of the methods we determined the structural surface charge density of magnetic colloids samples based on CoFe2O4@ɣ-Fe2O3 core-shell nanoparticles with three different mean sizes using both strategies. Concerning quickness, easiness and cost, the PCM has proved to be more advantageous than the SPM. Regarding the effectiveness, both methods were consistent in determining the saturation value of the structural charge, but the SPM was more accurate to describe the pH-dependence of the concentration of the charged surface sites. Considering the chemical safety, the methods are equivalent. Finally, both the SPM and PCM are reproducible and can be effectively applied to determine the saturation value of the surface charge density on magnetic colloids.
DOI: 10.6084/m9.figshare.5666173
title: Supplementary Material for: Alicaforsen, an Antisense Inhibitor of Intercellular Adhesion Molecule-1, in the Treatment for Left-Sided Ulcerative Colitis and Ulcerative Proctitis

description: <b><i>Background:</i></b> Data on the efficacy of intercellular adhesion molecule-1 antisense oligonucleotide alicaforsen in ulcerative colitis (UC) is inconsistent. <b><i>Methods:</i></b> All patients, who had received at least one dose of alicaforsen, were analyzed retrospectively. Alicaforsen’s efficacy was assessed in patients treated for left-sided UC and proctitis by comparing clinical and (if applicable) endoscopic disease activity before/after treatment. <b><i>Results:</i></b> Twelve patients were treated for left-sided UC or proctitis. Eleven patients received a 6-week course of a once-daily 240 mg alicaforsen enema formulation. In 1 patient, treatment was discontinued, because it was found to be inefficient. Disease activity measured by the partial Mayo score and 6-point symptom score was significantly reduced after treatment (6.0 vs. 2.4, <i>p</i> = 0.011 and 3.7 vs. 1.4, <i>p</i> = 0.008). Faecal calprotectin showed a trend towards reduction (484.4 vs. 179.5 μg/g, <i>p</i> = 0.063). Clinical improvement was achieved in 10 patients (83.3%). In 7 patients, a relapse occurred (70%). Median duration of clinical improvement was 18.0 weeks (range 1–112). Three patients showed an ongoing improvement of &gt;9 months. No adverse events were reported. <b><i>Conclusions:</i></b> A 6-week course of alicaforsen seemed to be safe and efficacious in inducing clinical improvement in patients with left-sided UC and proctitis. Prolonged clinical improvement was observed in many but not all patients.
DOI: 10.6084/m9.figshare.5666062
title: Additional file 3: of SP-A2 contributes to miRNA-mediated sex differences in response to oxidative stress: pro-inflammatory, anti-apoptotic, and anti-oxidant pathways are involved

description: Original gonadectomy miRNA tag count data (Fig. 4). (XLSX 123Â kb)
DOI: 10.6084/m9.figshare.5666062.v1
title: Additional file 3: of SP-A2 contributes to miRNA-mediated sex differences in response to oxidative stress: pro-inflammatory, anti-apoptotic, and anti-oxidant pathways are involved

description: Original gonadectomy miRNA tag count data (Fig. 4). (XLSX 123Â kb)
DOI: 10.6084/m9.figshare.5666059
title: Additional file 2: of SP-A2 contributes to miRNA-mediated sex differences in response to oxidative stress: pro-inflammatory, anti-apoptotic, and anti-oxidant pathways are involved

description: Original miRNA data used to generate Venn Diagrams (Fig. 3). (XLSX 75Â kb)
DOI: 10.6084/m9.figshare.5666059.v1
title: Additional file 2: of SP-A2 contributes to miRNA-mediated sex differences in response to oxidative stress: pro-inflammatory, anti-apoptotic, and anti-oxidant pathways are involved

description: Original miRNA data used to generate Venn Diagrams (Fig. 3). (XLSX 75Â kb)
DOI: 10.6084/m9.figshare.5666056
title: Additional file 1: of SP-A2 contributes to miRNA-mediated sex differences in response to oxidative stress: pro-inflammatory, anti-apoptotic, and anti-oxidant pathways are involved

description: Original miRNA data used to generate Figs. 1 and 2. (XLSX 1320Â kb)
DOI: 10.6084/m9.figshare.5666056.v1
title: Additional file 1: of SP-A2 contributes to miRNA-mediated sex differences in response to oxidative stress: pro-inflammatory, anti-apoptotic, and anti-oxidant pathways are involved

description: Original miRNA data used to generate Figs. 1 and 2. (XLSX 1320Â kb)
DOI: 10.6084/m9.figshare.5666032
title: Additional file 2: Table S1. of Intraspecific eye color variability in birds and mammals: a recent evolutionary event exclusive to humans and domestic animals

description: Survey (non-exhaustive due to paucity of published information) of eye color changes in wild bird species. The species with demonstrated changes in eye coloration are less than 1% of all extant bird species, and in most instances, changes occur when young birds become adults (see, e.g., Nogueira DM, Alves MAS. Iris colour as an indicator of age feature in female Brazilian tanagers (Passeriformes: Emberizidae) confirmed by molecular sexing technique. Int. J. Trop. Biol. 2008; 56(4): 629–1633). (XLSX 23 kb)
DOI: 10.6084/m9.figshare.5666032.v1
title: Additional file 2: Table S1. of Intraspecific eye color variability in birds and mammals: a recent evolutionary event exclusive to humans and domestic animals

description: Survey (non-exhaustive due to paucity of published information) of eye color changes in wild bird species. The species with demonstrated changes in eye coloration are less than 1% of all extant bird species, and in most instances, changes occur when young birds become adults (see, e.g., Nogueira DM, Alves MAS. Iris colour as an indicator of age feature in female Brazilian tanagers (Passeriformes: Emberizidae) confirmed by molecular sexing technique. Int. J. Trop. Biol. 2008; 56(4): 629–1633). (XLSX 23 kb)
DOI: 10.6084/m9.figshare.5665990
title: Additional file 3: of Routine blood tests and probability of cancer in patients referred with non-specific serious symptoms: a cohort study

description: Effect measure modification of gender and age on likelihood ratio of cancer. Pre-test probability of cancer: All patients = 12.2%; age-group 18–64 years = 5.9%, age-group ≥65 years = 18.0%, males = 15.1%, and females = 9.6%. Abbreviations: CRP: C-reactive protein, ESR: erythrocyte sedimentation rate; ALK: alanine aminotransaminase. (XLSX 14 kb)
DOI: 10.6084/m9.figshare.5665990.v1
title: Additional file 3: of Routine blood tests and probability of cancer in patients referred with non-specific serious symptoms: a cohort study

description: Effect measure modification of gender and age on likelihood ratio of cancer. Pre-test probability of cancer: All patients = 12.2%; age-group 18–64 years = 5.9%, age-group ≥65 years = 18.0%, males = 15.1%, and females = 9.6%. Abbreviations: CRP: C-reactive protein, ESR: erythrocyte sedimentation rate; ALK: alanine aminotransaminase. (XLSX 14 kb)
DOI: 10.6084/m9.figshare.5665975
title: Additional file 1: of Depression: point-prevalence and risk factors in a North Cyprus household adult cross-sectional study

description: Weight total - depression-prevalence dataset. (XLSX 258 kb)
DOI: 10.6084/m9.figshare.5665975.v1
title: Additional file 1: of Depression: point-prevalence and risk factors in a North Cyprus household adult cross-sectional study

description: Weight total - depression-prevalence dataset. (XLSX 258 kb)
DOI: 10.6084/m9.figshare.5665960
title: Additional file 1: of Routine blood tests and probability of cancer in patients referred with non-specific serious symptoms: a cohort study

description: An overview of the blood tests used in the triage function at Silkeborg Regional Hospital. Forty-eight different blood tests were used in the triage function. The highlighted blood tests represent the 28 blood tests included in the present study. Abbreviations: CRP: C-reactive protein; ESR: erythrocyte sedimentation rate; IgA: immunoglobulin A; IgG: immunoglobulin G; IgM: immunoglobulin M; MCHC: mean corpuscular haemoglobin concentration; ALT: alanine amino-transaminase; INR: international normalised ratio; LDH: lactate dehydrogenase; TSH: thyroid-stimulating hormone; HBA1C: glycated haemoglobin; sFLC: serum-free light chain κ/λ ratio; AFP: alpha-fetoprotein; hCG: human chorionic gonadotropin; PSA: prostate-specific antigen; CA-125: cancer antigen 125; ANA: antinuclear antibody. (XLSX 10 kb)
DOI: 10.6084/m9.figshare.5665960.v1
title: Additional file 1: of Routine blood tests and probability of cancer in patients referred with non-specific serious symptoms: a cohort study

description: An overview of the blood tests used in the triage function at Silkeborg Regional Hospital. Forty-eight different blood tests were used in the triage function. The highlighted blood tests represent the 28 blood tests included in the present study. Abbreviations: CRP: C-reactive protein; ESR: erythrocyte sedimentation rate; IgA: immunoglobulin A; IgG: immunoglobulin G; IgM: immunoglobulin M; MCHC: mean corpuscular haemoglobin concentration; ALT: alanine amino-transaminase; INR: international normalised ratio; LDH: lactate dehydrogenase; TSH: thyroid-stimulating hormone; HBA1C: glycated haemoglobin; sFLC: serum-free light chain κ/λ ratio; AFP: alpha-fetoprotein; hCG: human chorionic gonadotropin; PSA: prostate-specific antigen; CA-125: cancer antigen 125; ANA: antinuclear antibody. (XLSX 10 kb)
DOI: 10.6084/m9.figshare.5665951
title: MOESM5 of Sex determination mode does not affect body or genital development of the central bearded dragon (Pogona vitticeps)

description: Additional file 5: Table S2. Genotyping results for all embryos used in this study. IDÂ =Â specimen identifier, DNA concentration before (pre-Concentration) and after (post-Concentration) evaporation-based sample concentration. Genotyping results are the results from each PCR run (a minimum of 3, maximum of 5 runs), including the consensus genotype. Rows 4â 33 show data for DNA concentration in post-hatching specimens for comparison with the embryonic concentration data only.
DOI: 10.6084/m9.figshare.5665951.v1
title: MOESM5 of Sex determination mode does not affect body or genital development of the central bearded dragon (Pogona vitticeps)

description: Additional file 5: Table S2. Genotyping results for all embryos used in this study. IDÂ =Â specimen identifier, DNA concentration before (pre-Concentration) and after (post-Concentration) evaporation-based sample concentration. Genotyping results are the results from each PCR run (a minimum of 3, maximum of 5 runs), including the consensus genotype. Rows 4â 33 show data for DNA concentration in post-hatching specimens for comparison with the embryonic concentration data only.
DOI: 10.6084/m9.figshare.5665939
title: MOESM4 of Sex determination mode does not affect body or genital development of the central bearded dragon (Pogona vitticeps)

description: Additional file 4: Table S1. Datasheet of all specimens used in this study, including identifier (row names), age (in days post-lay, or DOO to denote specimen was sampled at oviposition), stage, type of specimen (C = from University of Canberra breeding colony, B = breeder), genotype, embryo weight (WTL), yolk weight (WTY), maternal sexual genotype (Mtype), incubation temperature (Temp), genital maturity score (1–6, see Fig. 4 and results for details), identity of mother, number of clutch (some mothers laid several clutches), treatment name.
DOI: 10.6084/m9.figshare.5665939.v1
title: MOESM4 of Sex determination mode does not affect body or genital development of the central bearded dragon (Pogona vitticeps)

description: Additional file 4: Table S1. Datasheet of all specimens used in this study, including identifier (row names), age (in days post-lay, or DOO to denote specimen was sampled at oviposition), stage, type of specimen (C = from University of Canberra breeding colony, B = breeder), genotype, embryo weight (WTL), yolk weight (WTY), maternal sexual genotype (Mtype), incubation temperature (Temp), genital maturity score (1–6, see Fig. 4 and results for details), identity of mother, number of clutch (some mothers laid several clutches), treatment name.
DOI: 10.6084/m9.figshare.5665936
title: Additional file 5: Table S2. of Differences in global gene expression in muscle tissue of Nellore cattle with divergent meat tenderness

description: Enriched GO terms obtained with the DAVID software for differentially expressed genes. (XLSX 14 kb)
DOI: 10.6084/m9.figshare.5665936.v1
title: Additional file 5: Table S2. of Differences in global gene expression in muscle tissue of Nellore cattle with divergent meat tenderness

description: Enriched GO terms obtained with the DAVID software for differentially expressed genes. (XLSX 14 kb)
DOI: 10.6084/m9.figshare.5665861
title: Additional file 6: of Species-specific genes under selection characterize the co-evolution of slavemaker and host lifestyles

description: Summary shared selected genes between slavemaker-host species pairs. (XLSX 39Â kb)
DOI: 10.6084/m9.figshare.5665861.v1
title: Additional file 6: of Species-specific genes under selection characterize the co-evolution of slavemaker and host lifestyles

description: Summary shared selected genes between slavemaker-host species pairs. (XLSX 39Â kb)
DOI: 10.6084/m9.figshare.5665849
title: Additional file 5: of Species-specific genes under selection characterize the co-evolution of slavemaker and host lifestyles

description: KEGG pathways assigned to positively selected genes per branch. (XLSX 21Â kb)
DOI: 10.6084/m9.figshare.5665849.v1
title: Additional file 5: of Species-specific genes under selection characterize the co-evolution of slavemaker and host lifestyles

description: KEGG pathways assigned to positively selected genes per branch. (XLSX 21Â kb)
DOI: 10.6084/m9.figshare.5665819
title: Additional file 3: of Species-specific genes under selection characterize the co-evolution of slavemaker and host lifestyles

description: Codeml results on selected gene identified on branches leading to slavemakers and hosts, as well as each single species. Plus information on shared and private selected genes. (XLSX 135Â kb)
DOI: 10.6084/m9.figshare.5665819.v1
title: Additional file 3: of Species-specific genes under selection characterize the co-evolution of slavemaker and host lifestyles

description: Codeml results on selected gene identified on branches leading to slavemakers and hosts, as well as each single species. Plus information on shared and private selected genes. (XLSX 135Â kb)
DOI: 10.6084/m9.figshare.5665747
title: Additional file 2: of Rethinking the evolution of eukaryotic metabolism: novel cellular partitioning of enzymes in stramenopiles links serine biosynthesis to glycolysis in mitochondria

description: Species represented in Fig. 2 and accession numbers of the analyzed protein sequences. (XLSX 43 kb)
DOI: 10.6084/m9.figshare.5665747.v1
title: Additional file 2: of Rethinking the evolution of eukaryotic metabolism: novel cellular partitioning of enzymes in stramenopiles links serine biosynthesis to glycolysis in mitochondria

description: Species represented in Fig. 2 and accession numbers of the analyzed protein sequences. (XLSX 43 kb)
DOI: 10.6084/m9.figshare.5665732
title: Additional file 1: Table S1. of Rethinking the evolution of eukaryotic metabolism: novel cellular partitioning of enzymes in stramenopiles links serine biosynthesis to glycolysis in mitochondria

description: Mitochondrial targeting scores of enzymes. (XLS 66 kb)
DOI: 10.6084/m9.figshare.5665732.v1
title: Additional file 1: Table S1. of Rethinking the evolution of eukaryotic metabolism: novel cellular partitioning of enzymes in stramenopiles links serine biosynthesis to glycolysis in mitochondria

description: Mitochondrial targeting scores of enzymes. (XLS 66 kb)
DOI: 10.6084/m9.figshare.5665699
title: Additional file 1: of Functional SNP allele discovery (fSNPd): an approach to find highly penetrant, environmental-triggered genotypes underlying complex human phenotypes

description: Use of fSNPd and the Supplementary Figure. This firstly documents the instructions for the installation of fSNPd, and its use. Secondly, it contains the Supplemental Figure entitled: Average read depth per base of genes in a test cohort of 40 individualsâ exomes - data derived from Supplemental Table S1. This shows a graph of calculate the average read coverage by all genes, and the legend details the methodology used. References used are given after the legend. Read number statistics of average depth of sequence reads for each exon of each gene included in the exomes of forty individuals. This is a large spreadsheet giving the detailed analysis of read depth achieved. Results and statistics are given for each gene and exon of each gene. Thus, the coverage of an exome of any desired exon can be determined. Simulations of the performance of fSNPd compared to an Association study approach in a variety of scenarios. Simulations were performed assuming that a rare SNP allele was fully penetrant when present (unless otherwise stated). For each Simulation SNP-1 is a common SNP (such as are used in Association studies) with allele A frequency = allele B frequency = 0.5 and SNP-2 (analysed in fSNPd) has the rare allele A frequency = .01 and the common allele B frequency = .99. The SNP-2 allele A is disease associated and always on a SNP-1 allele A background. Simulation are of: the number of SNPs causing a phenotype; different SNP-2 rare allele frequencies; if half of cases are non-genetic or rare SNPs allele penetrance 50%; and of using a cohort size of 3000, rather than 100 as used for all other simulations. (ZIP 8041 kb)
DOI: 10.6084/m9.figshare.5665687
title: Additional file 6: Table S6. of Nam Dia long, a Vietnamese folk formula, induces apoptosis in MCF-7 cells through various mechanisms of action

description: Upstream regulators predicted by the IPA at 24 h and 48 h after NDL treatment of MCF-7 cells. (XLSX 36 kb)
DOI: 10.6084/m9.figshare.5665687.v1
title: Additional file 6: Table S6. of Nam Dia long, a Vietnamese folk formula, induces apoptosis in MCF-7 cells through various mechanisms of action

description: Upstream regulators predicted by the IPA at 24 h and 48 h after NDL treatment of MCF-7 cells. (XLSX 36 kb)
DOI: 10.6084/m9.figshare.5665678
title: Additional file 2: of Design and validation of a German version of the GSRS-IBS - an analysis of its psychometric quality and factorial structure

description: Data_Validation_Reizdarmfragebogen. Dataset used during this study. (XLSX 103 kb)
DOI: 10.6084/m9.figshare.5665678.v1
title: Additional file 2: of Design and validation of a German version of the GSRS-IBS - an analysis of its psychometric quality and factorial structure

description: Data_Validation_Reizdarmfragebogen. Dataset used during this study. (XLSX 103 kb)
DOI: 10.6084/m9.figshare.5665669
title: Additional file 5: Table S5. of Nam Dia long, a Vietnamese folk formula, induces apoptosis in MCF-7 cells through various mechanisms of action

description: IPA canonical pathways identified at 24 h and 48 h from NDL treated MCF-7 cells. (XLSX 17 kb)