cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.5012378.v2
title: <i>Atg9a</i> deficiency causes axon-specific lesions including neuronal circuit dysgenesis

description: Conditional knockout mice for <i>Atg9a</i>, specifically in brain tissue, were generated to understand the roles of ATG9A in the neural tissue cells. The mice were born normally, but half of them died within one wk, and none lived beyond 4 wk of age. SQSTM1/p62 and NBR1, receptor proteins for selective autophagy, together with ubiquitin, accumulated in <i>Atg9a</i>-deficient neurosoma at postnatal d 15 (P15), indicating an inhibition of autophagy, whereas these proteins were significantly decreased at P28, as evidenced by immunohistochemistry, electron microscopy and western blot. Conversely, degenerative changes such as spongiosis of nerve fiber tracts proceeded in axons and their terminals that were occupied with aberrant membrane structures and amorphous materials at P28, although no clear-cut degenerative change was detected in neuronal cell bodies. Different from autophagy, diffusion tensor magnetic resonance imaging and histological observations revealed <i>Atg9a</i>-deficiency-induced dysgenesis of the corpus callosum and anterior commissure. As for the neurite extensions of primary cultured neurons, the neurite outgrowth after 3 d culturing was significantly impaired in primary neurons from <i>atg9a</i>-KO mouse brains, but not in those from <i>atg7</i>-KO and <i>atg16l1</i>-KO brains. Moreover, this tendency was also confirmed in <i>Atg9a</i>-knockdown neurons under an <i>atg7</i>-KO background, indicating the role of ATG9A in the regulation of neurite outgrowth that is independent of autophagy. These results suggest that <i>Atg9a</i> deficiency causes progressive degeneration in the axons and their terminals, but not in neuronal cell bodies, where the degradations of SQSTM1/p62 and NBR1 were insufficiently suppressed. Moreover, the deletion of <i>Atg9a</i> impaired nerve fiber tract formation.
DOI: 10.6084/m9.figshare.5012378.v1
title: <i>Atg9a</i> deficiency causes axon-specific lesions including neuronal circuit dysgenesis

description: Conditional knockout mice for <i>Atg9a</i>, specifically in brain tissue, were generated to understand the roles of ATG9A in the neural tissue cells. The mice were born normally, but half of them died within one wk, and none lived beyond 4 wk of age. SQSTM1/p62 and NBR1, receptor proteins for selective autophagy, together with ubiquitin, accumulated in <i>Atg9a</i>-deficient neurosoma at postnatal d 15 (P15), indicating an inhibition of autophagy, whereas these proteins were significantly decreased at P28, as evidenced by immunohistochemistry, electron microscopy and western blot. Conversely, degenerative changes such as spongiosis of nerve fiber tracts proceeded in axons and their terminals that were occupied with aberrant membrane structures and amorphous materials at P28, although no clear-cut degenerative change was detected in neuronal cell bodies. Different from autophagy, diffusion tensor magnetic resonance imaging and histological observations revealed <i>Atg9a</i>-deficiency-induced dysgenesis of the corpus callosum and anterior commissure. As for the neurite extensions of primary cultured neurons, the neurite outgrowth after 3 d culturing was significantly impaired in primary neurons from <i>atg9a</i>-KO mouse brains, but not in those from <i>atg7</i>-KO and <i>atg16l1</i>-KO brains. Moreover, this tendency was also confirmed in <i>Atg9a</i>-knockdown neurons under an <i>atg7</i>-KO background, indicating the role of ATG9A in the regulation of neurite outgrowth that is independent of autophagy. These results suggest that <i>Atg9a</i> deficiency causes progressive degeneration in the axons and their terminals, but not in neuronal cell bodies, where the degradations of SQSTM1/p62 and NBR1 were insufficiently suppressed. Moreover, the deletion of <i>Atg9a</i> impaired nerve fiber tract formation.
DOI: 10.6084/m9.figshare.5012075
title: Supplementary Material for: Low Back Pain in Pregnancy: Investigations, Management, and Role of Neuraxial Analgesia and Anaesthesia: A Systematic Review

description: <b><i>Background:</i></b> Low back pain (LBP) is commonly experienced during pregnancy and is often poorly managed. There is much ambiguity in diagnostic work-up, appropriate management and decision-making regarding the use of neuraxial analgesia and anaesthesia during labour and delivery in these patients. This systematic review summarises the evidence regarding investigations, management strategies and considerations around performing neuraxial blocks for pregnant women with LBP. <b><i>Methods:</i></b> We searched 3 databases and reviewed literature concerning LBP in pregnancy with regards to diagnostic modalities, management strategies and use of neuraxial techniques for facilitating labour and delivery.<b><i> Results:</i></b> In all, we included 78 studies in this review, with 32 studies concerning diagnostic investigations, 56 studies involving management strategies, and 4 studies regarding the use of neuraxial techniques for labour and delivery. <b><i>Summary:</i></b> MRI is the safest investigative modality for LBP in pregnancy. Antenatal educational programmes, exercise and steroid injections into the epidural space or sacroiliac joints may help with pain management. Worsening neurological deficits, vertebral fractures and tumours may need surgical management. There is limited evidence on challenges of performing neuraxial blocks in the peripartum period for analgesia and anaesthesia, but there is a potential for increased risk of neurological complications in parturients with pre-existing neurological deficits.
DOI: 10.6084/m9.figshare.5012069
title: Analogia entis as analogy universalized and formalized rigorously and mathematically in quantum mechanics as the shared base of nature and knowledge

description: <br>The wave function of any quantum system can be interpreted as its quantitative degree of analogy to any other quantum system Therefore, it represents analogia entis in a rigorous, formal and mathematical way in a scientific discipline such as quantum mechanics Any quantum state of any quantum system expressed by a wave function may be interpreted as the represented quantitatively analogy of that quantum system to all other quantum systems in the universe Quantum mechanics can be interpreted as a scientific doctrine of analogia entis
DOI: 10.6084/m9.figshare.5012072
title: Diffusing capacity data. Carbon monoxide and Nitric oxide

description: Data for the publication: Thomas A, Hanel B, Marott JL, Buchvald F, Mortensen J, Nielsen KG (2014) The Single-Breath Diffusing Capacity of CO and NO in Healthy Children of European Descent. PLoS ONE 9(12): e113177. https://doi.org/10.1371/journal.pone.0113177<br>
DOI: 10.6084/m9.figshare.5012069.v1
title: Analogia entis as analogy universalized and formalized rigorously and mathematically in quantum mechanics as the shared base of nature and knowledge

description: <br>The wave function of any quantum system can be interpreted as its quantitative degree of analogy to any other quantum system Therefore, it represents analogia entis in a rigorous, formal and mathematical way in a scientific discipline such as quantum mechanics Any quantum state of any quantum system expressed by a wave function may be interpreted as the represented quantitatively analogy of that quantum system to all other quantum systems in the universe Quantum mechanics can be interpreted as a scientific doctrine of analogia entis
DOI: 10.6084/m9.figshare.5012072.v1
title: Diffusion Data.pdf

description: Data for the publication: Thomas A, Hanel B, Marott JL, Buchvald F, Mortensen J, Nielsen KG (2014) The Single-Breath Diffusing Capacity of CO and NO in Healthy Children of European Descent. PLoS ONE 9(12): e113177. https://doi.org/10.1371/journal.pone.0113177<br>
DOI: 10.6084/m9.figshare.5011937
title: Supplementary Material for: Theorie-Praxis-Netzwerke in verhaltenstherapeutischer Ausbildung: Schulung, Selbsterfahrung und Einsatz in der Therapie am Beispiel von Achtsamkeit

description: Hintergrund: Die Bausteine der theoretischen und praktischen verhaltenstherapeutischen Ausbildung finden selten direkt aufeinander bezogen statt. Die stärkere Vernetzung von Schulung, Übungsintervall und Einsatz in der Therapie von relevanten therapeutischen Interventionen ist wünschenswert. Am Beispiel einer Untersuchung von Achtsamkeitsinterventionen wurde im vorliegenden Manuskript der Versuch unternommen, dieses Thema zu adressieren. Methodik: 27 Ausbildungstherapeuten führten Achtsamkeits-Workshops mit Selbsterfahrungsintervallen durch. Darauf aufbauend wurden bei 36 Patienten standardisierte sitzungseinleitende Übungen mit Achtsamkeitselementen direkt in die Ausbildungstherapien integriert. Das Programm wurde auf Akzeptanz, Durchführbarkeit und Effektivität überprüft. Die Symptomreduktion (Beck Depression Inventory (BDI-II), Brief Symptom Inventory (BSI)) von Probatorik zur 15. Therapiesitzung wurde varianzanalytisch mit Patienten der Routineversorgung als Kontrollgruppe verglichen. Ergebnisse: In qualitativen Interviews zeigten sich positive Achtsamkeitserfahrungen. Generell waren Akzeptanz und Durchführbarkeit des Theorie-Praxis-Netzwerks hoch. Laut Aussagen der Ausbildungstherapeuten wurden hier sinnvolle Schnittstellen zwischen theoretischer und praktischer Ausbildung realisiert. Bezüglich der Symptomreduktion zeigten sich für Patienten der Achtsamkeitsgruppe und Routineversorgung ähnliche Effektstärken, hier bestanden keine signifikanten Unterschiede. Schlussfolgerung: Die Kombination aus Achtsamkeits-Work-shops und darauf aufbauenden sitzungseinleitenden Übungen wurde als sinnvoll erlebt, zeigte allerdings keine stärkeren klinischen Effekte als die Routineversorgung. Zukünftige Forschung sollte Theorie-Praxis-Netzwerke in anderen Bereichen (z.B. Progressive Muskelrelaxation, Compassion) untersuchen. Zusätzlich zu positiven Durchführbarkeits- und Akzeptanzbefunden könnten dort auch klinisch relevante Effekte identifizierbar sein.
DOI: 10.6084/m9.figshare.5012072.v4
title: Diffusing capacity data. Carbon monoxide and Nitric oxide

description: Data for the publication: Thomas A, Hanel B, Marott JL, Buchvald F, Mortensen J, Nielsen KG (2014) The Single-Breath Diffusing Capacity of CO and NO in Healthy Children of European Descent. PLoS ONE 9(12): e113177. https://doi.org/10.1371/journal.pone.0113177<br>
DOI: 10.6084/m9.figshare.5012072.v3
title: Diffusion Data.pdf

description: Data for the publication: Thomas A, Hanel B, Marott JL, Buchvald F, Mortensen J, Nielsen KG (2014) The Single-Breath Diffusing Capacity of CO and NO in Healthy Children of European Descent. PLoS ONE 9(12): e113177. https://doi.org/10.1371/journal.pone.0113177<br>
DOI: 10.6084/m9.figshare.5011871
title: Experiment2Errors.xlsx

description: Experiment 2 Errors
DOI: 10.6084/m9.figshare.5011868
title: Experiment2RTs.xlsx

description: Experiment 2 RTs
DOI: 10.6084/m9.figshare.5011871.v1
title: Experiment2Errors.xlsx

description: Experiment 2 Errors
DOI: 10.6084/m9.figshare.5011865
title: Experiment1Errors.xlsx

description: Experiment 1 Errors
DOI: 10.6084/m9.figshare.5011868.v1
title: Experiment2RTs.xlsx

description: Experiment 2 RTs
DOI: 10.6084/m9.figshare.5011859
title: Experiment4RTs.xlsx

description: Experiment 4 RTs
DOI: 10.6084/m9.figshare.5011862
title: Experiment1RTs.xlsx

description: Experiment 1 RTs
DOI: 10.6084/m9.figshare.5011865.v1
title: Experiment1Errors.xlsx

description: Experiment 1 Errors
DOI: 10.6084/m9.figshare.5011859.v1
title: Experiment4RTs.xlsx

description: Experiment 4 RTs
DOI: 10.6084/m9.figshare.5011862.v1
title: Experiment1RTs.xlsx

description: Experiment 1 RTs
DOI: 10.6084/m9.figshare.5011850
title: Experiment3Errors.xlsx

description: Experiment 3 Errors
DOI: 10.6084/m9.figshare.5011856
title: Experiment4Errors.xlsx

description: Experiment 4 Errors
DOI: 10.6084/m9.figshare.5011856.v1
title: Experiment4Errors.xlsx

description: Experiment 4 Errors
DOI: 10.6084/m9.figshare.5011853
title: Experiment3RTs.xlsx

description: Experiment 3 RTS
DOI: 10.6084/m9.figshare.5011850.v1
title: Experiment3Errors.xlsx

description: Experiment 3 Errors
DOI: 10.6084/m9.figshare.5011853.v1
title: Experiment3RTs.xlsx

description: Experiment 3 RTS
DOI: 10.6084/m9.figshare.5011838.v1
title: 5_breeds_sheep_novel_SNP

description: New SNPs identified by RNA-seq in the ovine skeletal muscle by sequencing the <i>longissimus dorsi</i> transcriptome.
DOI: 10.6084/m9.figshare.5011838.v2
title: 5_breeds_sheep_SNP

description: SNPs identified by RNA-seq in the ovine skeletal muscle by sequencing the <i>longissimus dorsi</i> transcriptome.
DOI: 10.6084/m9.figshare.5011838.v3
title: 5_breeds_sheep_SNP

description: SNPs identified by RNA-seq in the ovine skeletal muscle by sequencing the <i>longissimus dorsi</i> transcriptome.
DOI: 10.6084/m9.figshare.5011772
title: passive_vs_assistive_data.csv

description: Difference between pre and post training performance for participants in three different training conditions, full guidance, active control, and vision only.
DOI: 10.6084/m9.figshare.5011838
title: Expression patterns and genetic variation of the ovine skeletal muscle transcriptome of sheep from five Spanish meat breeds

description: SNPs identified by RNA-seq in the ovine skeletal muscle by sequencing the <i>longissimus dorsi</i> transcriptome.
DOI: 10.6084/m9.figshare.5011772.v1
title: passive_vs_assistive_data.csv

description: Difference between pre and post training performance for participants in three different training conditions, full guidance, active control, and vision only.
DOI: 10.6084/m9.figshare.5011715
title: Data file with FTW included from Three-month-old human infants use vocal cues of body size

description: Data file with failure-to-watch trials included.
DOI: 10.6084/m9.figshare.5011715.v1
title: Data file with FTW included from Three-month-old human infants use vocal cues of body size

description: Data file with failure-to-watch trials included.
DOI: 10.6084/m9.figshare.5011703
title: S5 Looms ancestral states from The evolution of an ancient technology

description: Ancestral states for nodes on the Bayesian consensus tree
DOI: 10.6084/m9.figshare.5011691
title: S4 Looms data file from The evolution of an ancient technology

description: Nexus file containing survey data on loom characters
DOI: 10.6084/m9.figshare.5011682
title: Data file from Three-month-old human infants use vocal cues of body size

description: Primary data file.
DOI: 10.6084/m9.figshare.5011682.v1
title: Data file from Three-month-old human infants use vocal cues of body size

description: Primary data file.
DOI: 10.6084/m9.figshare.5011664
title: S3 Looms characters and short codes from The evolution of an ancient technology

description: Looms characters and short codes used in Nexus file
DOI: 10.6084/m9.figshare.5011655
title: Spruyt & De Houwer (submitted). On the automaticity of relational stimulus processing: Experiment 2

description: Zip folder with raw data files of Experiment 2
DOI: 10.17028/rd.lboro.5011631
title: Equivalent Stiffness Model of a PEM Fuel Cell

description: Underlying data and model for publication titled 'Equivalent Stiffness Model of a PEM Fuel Cell Stack including hygrothermal effects and dimensional tolerances'
DOI: 10.6084/m9.figshare.5011637
title: Underwater recordings of the whistles of bottlenose dolphins in Fremantle Inner Harbour, Western Australia

description: Dolphins use frequency-modulated whistles for a variety of social functions. Whistles vary in their characteristics according to context, such as activity state, group size, group composition, geographic location, and ambient noise levels. Therefore, comparison of whistle characteristics can be used to address numerous research questions regarding dolphin populations and behaviour. However, logistical and economic constraints on dolphin research have resulted in data collection biases, inconsistent analytical approaches, and knowledge gaps. Here, we present an acoustic dataset of bottlenose dolphin (<i>Tursiops aduncus</i>) whistles recorded in the Fremantle Inner Harbour, Western Australia. Digital files of individual whistles and corresponding measurements make this dataset available to researchers to address future questions regarding variations within and between dolphin communities. Data were collected using an autonomous recorder and analysed using a range of acoustic measurements. Acoustic data review identified 336 whistles, which were subsequently measured for six key characteristics using Raven Pro software. These six characteristics were: duration, minimum frequency, maximum frequency, delta frequency, start frequency and end frequency. Of these 336 whistles, 164 “high-quality” whistles were manually measured to provide an additional five acoustic characteristics. These additional characteristics were: inflection points, extrema, breaks and saddles. Each of the 336 whistles is stored as an individual .wav file, with a sequential name (Wh_0001, Wh_0002, Wh_0003, etc). File names correspond with a unique “Whistle Number” in an Excel spreadsheet. The date and time of each 10 min acoustic recording are presented, along with a column called “Whistle Begins” which lists the point within a recording when a whistle occurs. This spreadsheet also contains information regarding the whistle quality (Grades 1-3) and the whistle characteristics measured. Duration is measured in seconds, all frequency characteristics are measured in Hz, harmonics are present (1) or absent (0), and all remaining characteristics are counts. Frequency measurements were rounded to the nearest 100 Hz. Further information is available in the accompanying Data Descriptor published in Scientific Data.
DOI: 10.6084/m9.figshare.5011643
title: Supplementary Material for: Dialysis Access as an Area of Improvement in Elderly Incident Hemodialysis Patients: Results from a Cohort Study from the International Monitoring Dialysis Outcomes Initiative

description: <b><i>Background:</i></b> Commencing hemodialysis (HD) using a catheter is associated with a higher risk of adverse outcomes, and early conversion from central-venous catheter (CVC) to arteriovenous fistula/graft (non-CVC) improves outcomes. We investigated CVC prevalence and conversion, and their effects on outcomes during the first year of HD in a multinational cohort of elderly patients. <b><i>Methods:</i></b> Patients ≥70 years from the MONDO Initiative who commenced HD between 2000 and 2010 in Asia-Pacific, Europe, North-, and South-America and survived at least 6 months were included in this investigation. We stratified by age (70-79 years [younger] vs. ≥80 years [older]) and compared access types (at first and last available date) and their changes. We studied the association between access at initiation and conversion, respectively, and all-cause mortality using Kaplan-Meier curve and Cox regression, and predicted the absence of conversion from catheter to non-CVC using adjusted logistic regression. <b><i>Results:</i></b> In 14,966 elderly, incident HD patients, survival was significantly worse when using a CVC at all times. In Europe, the conversion frequency from CVC to non-CVC was higher in the younger fraction. Conversion from non-CVC to CVC was associated with worsened outcomes only in the older fraction. <b><i>Conclusion:</i></b> These results corroborate the need for early HD preparation in the elderly HD population. Treatment of elderly patients who commence HD with a CVC should be planned considering aspects of individual clinical risk assessment. Differences in treatment practices in predialysis care specific to the elderly as a population may influence access care and conversion rate.
DOI: 10.6084/m9.figshare.5011655.v1
title: Spruyt & De Houwer (submitted). On the automaticity of relational stimulus processing: Experiment 2

description: Zip folder with raw data files of Experiment 2
DOI: 10.6084/m9.figshare.5011619
title: Evolution of Stress-Induced Mutagenesis in the Presence of Horizontal Gene Transfer

description: Simulation results for work accepted for publication in The American Naturalist
DOI: 10.6084/m9.figshare.5011616
title: Selection of drought-tolerant tef (<i>Eragrostis tef</i>) genotypes using drought tolerance indices

description: Drought stress is one of the major abiotic constraints affecting production and productivity of tef (<i>Eragrostis tef</i>). Genetic resources and selection methodologies are among the prerequisites to improve the efficiency of breeding for drought tolerance. The objectives of this study were to determine the principal selection indices and to identify promising genetic resources of tef for drought tolerance breeding. A total of 144 tef genotypes were evaluated using a simple lattice design with two replications. Genotypes showed highly significant (<i>p</i> ≤ 0.01) differences for 10 drought tolerance indices. Principal component and correlation analyses revealed mean productivity, harmonic mean, geometric mean productivity and stress tolerance index as the principal indices highly correlated with grain yield in the stressed and non-stressed environments, indicating their suitability for identifying superior tef genotypes. Genotypes 215678 (g25) and Dschanger (g133) were adaptable to both stressed and non-stressed environments, which could be useful for drought stress tolerance breeding. Genotypes DZ-Cr-387 (g1), 9403 (g4), 205896 (g48) and 9415 (g122) were selected for their higher grain yield under the non-stressed condition. Genotypes DZ-Cr-385 (g22) and DZ-Cr-37 (g28) were selected for their lower yield reduction under moisture stress, intermediate grain yield performance in the non-stressed environment and high grain yield potential in the moisture-stressed environment.
DOI: 10.6084/m9.figshare.5011619.v1
title: Evolution of Stress-Induced Mutagenesis in the Presence of Horizontal Gene Transfer

description: Simulation results for work accepted for publication in The American Naturalist
DOI: 10.6084/m9.figshare.5011607
title: Data from high-density peptide microarray with pit viper venom proteins

description: This data is the basis of a study of linear epitope elements in toxins and other components from pit viper venom. <br><br>10.1371/journal.pntd.0005768
DOI: 10.6084/m9.figshare.5011616.v2
title: Selection of drought-tolerant tef (<i>Eragrostis tef</i>) genotypes using drought tolerance indices

description: Drought stress is one of the major abiotic constraints affecting production and productivity of tef (<i>Eragrostis tef</i>). Genetic resources and selection methodologies are among the prerequisites to improve the efficiency of breeding for drought tolerance. The objectives of this study were to determine the principal selection indices and to identify promising genetic resources of tef for drought tolerance breeding. A total of 144 tef genotypes were evaluated using a simple lattice design with two replications. Genotypes showed highly significant (<i>p</i> ≤ 0.01) differences for 10 drought tolerance indices. Principal component and correlation analyses revealed mean productivity, harmonic mean, geometric mean productivity and stress tolerance index as the principal indices highly correlated with grain yield in the stressed and non-stressed environments, indicating their suitability for identifying superior tef genotypes. Genotypes 215678 (g25) and Dschanger (g133) were adaptable to both stressed and non-stressed environments, which could be useful for drought stress tolerance breeding. Genotypes DZ-Cr-387 (g1), 9403 (g4), 205896 (g48) and 9415 (g122) were selected for their higher grain yield under the non-stressed condition. Genotypes DZ-Cr-385 (g22) and DZ-Cr-37 (g28) were selected for their lower yield reduction under moisture stress, intermediate grain yield performance in the non-stressed environment and high grain yield potential in the moisture-stressed environment.
DOI: 10.6084/m9.figshare.5011607.v1
title: Data from high-density peptide microarray with pit viper venom proteins

description: This data is the basis of a study of linear epitope elements in toxins and other components from pit viper venom. <br><br>10.1371/journal.pntd.0005768