cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.1409398.v292
title: ABO phenotype protected reproduction as it is based on fucosylations.

description: The molecular biological relationship between human fertility and the formation of the ABO(H) blood group phenotype is evident in the rare (Oh) or <i>Bombay</i> blood type, which, based on the history of his own family, the <i>Darwin/Wedgewood Dynasty</i>, Charles Darwin would have interpreted as resulting from reduced fertility in consanguinities. In its native form, the <i>Bombay</i> type occurs in individuals with an extremely rare genotype (h/h;se/se), in whom the fucosyltransferases FUT1 and FUT2 are not produced due to point mutations. These enzymes, which are encoded on chromosome 19, are epistatically connected with the A and B allelic glycotransferase functions encoded on chromosome 9, and the fucosyl residues provide the functional-structural basis for the formation of any ABO(H) phenotype on the cell surface or in secretions and plasma proteins. Immunoglobulins are also heavily fucosylated, and fucosyl residues appear, via developmental variations in their positions on cell surfaces and on the heavy chains of immunoglobulins, to increase or reduce antibody-mediated cellular cytotoxicity involving physiological anti-self-reactivity; moreover, by regulating the assembly and intracellular signalling of precursor B cell receptors, the core fucosylation of immunoglobulin heavy chains represents a key mechanism in clonal selection. In fact, the seminal plasma of leukospermic infertile men has been reported to exhibit high levels of poorly core-fucosylated IgG. Thus, when antibody-dependent cellular cytotoxicity can be increased 50-fold simply by removing the single fucose residue from the Fc glycan, in <i>Bombay </i>type individuals, the non-somatic glycosylation processes of embryogenic stem cell-to-germ cell transformation are most likely exposed to metabolic competition with multiple glycosidic sites of poorly fucosylated, glycan-depleted immunoglobulins, suggesting to promote anti-self-reactive cellular cytotoxicity in male gamete performance.
DOI: 10.6084/m9.figshare.1409398.v293
title: ABO phenotype protected reproduction as it is based on fucosylations.

description: The molecular biological relationship between human fertility and the formation of the ABO(H) blood group phenotype is evident in the rare (Oh) or <i>Bombay</i> blood type, which, based on the history of his own family, the <i>Darwin/Wedgewood Dynasty</i>, Charles Darwin would have interpreted as resulting from reduced fertility in consanguinities. In its native form, the <i>Bombay</i> type occurs in individuals with an extremely rare genotype (h/h;se/se), in whom the fucosyltransferases FUT1 and FUT2 are not produced due to point mutations. These enzymes, which are encoded on chromosome 19, are epistatically connected with the A and B allelic glycotransferase functions encoded on chromosome 9, and the fucosyl residues provide the functional-structural basis for the formation of any ABO(H) phenotype on the cell surface or in secretions and plasma proteins. Immunoglobulins are also heavily fucosylated, and fucosyl residues appear, via developmental variations in their positions on cell surfaces and on the heavy chains of immunoglobulins, to increase or reduce antibody-mediated cellular cytotoxicity involving physiological anti-self-reactivity; moreover, by regulating the assembly and intracellular signalling of precursor B cell receptors, the core fucosylation of immunoglobulin heavy chains represents a key mechanism in clonal selection. In fact, the seminal plasma of leukospermic infertile men has been reported to exhibit high levels of poorly core-fucosylated IgG. Thus, when antibody-dependent cellular cytotoxicity can be increased 50-fold simply by removing the single fucose residue from the Fc glycan, in <i>Bombay </i>type individuals, the non-somatic glycosylation processes of embryogenic stem cell-to-germ cell transformation are most likely exposed to metabolic competition with multiple glycosidic sites of poorly fucosylated, glycan-depleted immunoglobulins, suggesting to promote anti-self-reactive cellular cytotoxicity in male gamete performance.
DOI: 10.6084/m9.figshare.1394961.v1
title: Elucidating the composition and conservation of the autophagy pathway in photosynthetic eukaryotes

description: Aquatic photosynthetic eukaryotes represent highly diverse groups (green, red and chromalveolate algae) derived from multiple endosymbiosis events, covering a wide spectrum of the tree of life. They are responsible for about 50% of the global photosynthesis and serve as the foundation for oceanic and fresh water food webs. Although the ecophysiology and molecular ecology of some algal species are extensively studied, some basic aspects of algal cell biology are still underexplored. The recent wealth of genomic resources from algae has opened new frontiers to decipher the role of cell signaling pathways and their function in an ecological and biotechnological context. Here, we took a bioinformatic approach to explore the distribution and conservation of TOR and autophagy-related (ATG) proteins (Atg in yeast) in diverse algal groups. Our genomic analysis demonstrates conservation of TOR and ATG proteins in green algae. In contrast, in all 5 available red algal genomes, we could not detect the sequences that code for any of the 17 core ATG proteins examined, albeit TOR and its interacting proteins are conserved. This intriguing data suggests that the autophagy pathway is not conserved in red algae as it is in the entire eukaryote domain. In contrast, chromalveolates, despite being derived from the red-plastid lineage, retain and express <i>ATG</i> genes, which raises a fundamental question regarding the acquisition of <i>ATG</i> genes during algal evolution. Among chromalveolates, <i>Emiliania huxleyi</i> (Haptophyta), a bloom-forming coccolithophore, possesses the most complete set of <i>ATG</i> genes, and may serve as a model organism to study autophagy in marine protists with great ecological significance.
DOI: 10.6084/m9.figshare.1409398.v294
title: ABO phenotype protected reproduction as it is based on fucosylations.

description: The molecular biological relationship between human fertility and the formation of the ABO(H) blood group phenotype is evident in the rare (Oh) or <i>Bombay</i> blood type, which, based on the history of his own family, the <i>Darwin/Wedgewood Dynasty</i>, Charles Darwin would have interpreted as resulting from reduced fertility in consanguinities. In its native form, the <i>Bombay</i> type occurs in individuals with an extremely rare genotype (h/h;se/se), in whom the fucosyltransferases FUT1 and FUT2 are not produced due to point mutations. These enzymes, which are encoded on chromosome 19, are epistatically connected with the A and B allelic glycotransferase functions encoded on chromosome 9, and the fucosyl residues provide the functional-structural basis for the formation of any ABO(H) phenotype on the cell surface or in secretions and plasma proteins. Immunoglobulins are also heavily fucosylated, and fucosyl residues appear, via developmental variations in their positions on cell surfaces and on the heavy chains of immunoglobulins, to increase or reduce antibody-mediated cellular cytotoxicity involving physiological anti-self-reactivity; moreover, by regulating the assembly and intracellular signalling of precursor B cell receptors, the core fucosylation of immunoglobulin heavy chains represents a key mechanism in clonal selection. In fact, the seminal plasma of leukospermic infertile men has been reported to exhibit high levels of poorly core-fucosylated IgG. Thus, when antibody-dependent cellular cytotoxicity can be increased 50-fold simply by removing the single fucose residue from the Fc glycan, in <i>Bombay </i>type individuals, the non-somatic glycosylation processes of embryogenic stem cell-to-germ cell transformation are most likely exposed to metabolic competition with multiple glycosidic sites of poorly fucosylated, glycan-depleted immunoglobulins, suggesting to promote anti-self-reactive cellular cytotoxicity in male gamete performance.
DOI: 10.6084/m9.figshare.1394961.v3
title: Elucidating the composition and conservation of the autophagy pathway in photosynthetic eukaryotes

description: Aquatic photosynthetic eukaryotes represent highly diverse groups (green, red, and chromalveolate algae) derived from multiple endosymbiosis events, covering a wide spectrum of the tree of life. They are responsible for about 50% of the global photosynthesis and serve as the foundation for oceanic and fresh water food webs. Although the ecophysiology and molecular ecology of some algal species are extensively studied, some basic aspects of algal cell biology are still underexplored. The recent wealth of genomic resources from algae has opened new frontiers to decipher the role of cell signaling pathways and their function in an ecological and biotechnological context. Here, we took a bioinformatic approach to explore the distribution and conservation of TOR and autophagy-related (ATG) proteins (Atg in yeast) in diverse algal groups. Our genomic analysis demonstrates conservation of TOR and ATG proteins in green algae. In contrast, in all 5 available red algal genomes, we could not detect the sequences that encode for any of the 17 core ATG proteins examined, albeit TOR and its interacting proteins are conserved. This intriguing data suggests that the autophagy pathway is not conserved in red algae as it is in the entire eukaryote domain. In contrast, chromalveolates, despite being derived from the red-plastid lineage, retain and express <i>ATG</i> genes, which raises a fundamental question regarding the acquisition of <i>ATG</i> genes during algal evolution. Among chromalveolates, <i>Emiliania huxleyi</i> (Haptophyta), a bloom-forming coccolithophore, possesses the most complete set of <i>ATG</i> genes, and may serve as a model organism to study autophagy in marine protists with great ecological significance.
DOI: 10.6084/m9.figshare.1409398.v295
title: ABO phenotype protected reproduction as it is based on fucosylations.

description: The molecular biological relationship between human fertility and the formation of the ABO(H) blood group phenotype is evident in the rare (Oh) or <i>Bombay</i> blood type, which, based on the history of his own family, the <i>Darwin/Wedgewood Dynasty</i>, Charles Darwin would have interpreted as resulting from reduced fertility in consanguinities. In its native form, the <i>Bombay</i> type occurs in individuals with an extremely rare genotype (h/h;se/se), in whom the fucosyltransferases FUT1 and FUT2 are not produced due to point mutations. These enzymes, which are encoded on chromosome 19, are epistatically connected with the A and B allelic glycotransferase functions encoded on chromosome 9, and the fucosyl residues provide the functional-structural basis for the formation of any ABO(H) phenotype on the cell surface or in secretions and plasma proteins. Immunoglobulins are also heavily fucosylated, and fucosyl residues appear, via developmental variations in their positions on cell surfaces and on the heavy chains of immunoglobulins, to increase or reduce antibody-mediated cellular cytotoxicity involving physiological anti-self-reactivity; moreover, by regulating the assembly and intracellular signalling of precursor B cell receptors, the core fucosylation of immunoglobulin heavy chains represents a key mechanism in clonal selection. In fact, the seminal plasma of leukospermic infertile men has been reported to exhibit high levels of poorly core-fucosylated IgG. Thus, when antibody-dependent cellular cytotoxicity can be increased 50-fold simply by removing the single fucose residue from the Fc glycan, in <i>Bombay </i>type individuals, the non-somatic glycosylation processes of embryogenic stem cell-to-germ cell transformation are most likely exposed to metabolic competition with multiple glycosidic sites of poorly fucosylated, glycan-depleted immunoglobulins, suggesting to promote anti-self-reactive cellular cytotoxicity in male gamete performance.
DOI: 10.6084/m9.figshare.1394961.v2
title: Elucidating the composition and conservation of the autophagy pathway in photosynthetic eukaryotes

description: Aquatic photosynthetic eukaryotes represent highly diverse groups (green, red, and chromalveolate algae) derived from multiple endosymbiosis events, covering a wide spectrum of the tree of life. They are responsible for about 50% of the global photosynthesis and serve as the foundation for oceanic and fresh water food webs. Although the ecophysiology and molecular ecology of some algal species are extensively studied, some basic aspects of algal cell biology are still underexplored. The recent wealth of genomic resources from algae has opened new frontiers to decipher the role of cell signaling pathways and their function in an ecological and biotechnological context. Here, we took a bioinformatic approach to explore the distribution and conservation of TOR and autophagy-related (ATG) proteins (Atg in yeast) in diverse algal groups. Our genomic analysis demonstrates conservation of TOR and ATG proteins in green algae. In contrast, in all 5 available red algal genomes, we could not detect the sequences that encode for any of the 17 core ATG proteins examined, albeit TOR and its interacting proteins are conserved. This intriguing data suggests that the autophagy pathway is not conserved in red algae as it is in the entire eukaryote domain. In contrast, chromalveolates, despite being derived from the red-plastid lineage, retain and express <i>ATG</i> genes, which raises a fundamental question regarding the acquisition of <i>ATG</i> genes during algal evolution. Among chromalveolates, <i>Emiliania huxleyi</i> (Haptophyta), a bloom-forming coccolithophore, possesses the most complete set of <i>ATG</i> genes, and may serve as a model organism to study autophagy in marine protists with great ecological significance.
DOI: 10.6084/m9.figshare.1394955
title: Does the mamastrovirus 5 cause gastroenteritis in dogs? MAstVs ORF2 aminoacid tree

description: Evolutionary relationship of MAstV5 with representative MAstV genera. The percentage of replicates in which the associated virus clustered together in the bootstrap test (1000 replicates) is shown next to the branches in each tree. The trees are drawn to scale; bars represent the number of substitutions per site. All positions except ambiguous positions were included. GenBank accession numbers are shown on the tree. Evolutionary tree based on the partial nucleotide sequences of the ORF2 of 65 sequences of MAstV5. The samples obtained in the present study are highlighted with a symbol (bold).
DOI: 10.6084/m9.figshare.1394957
title: Good liars are neither ‘Dark’ nor Self-Deceptive

description: Dataset to accompany PLOSOne article PONE-D-14-49497
DOI: 10.6084/m9.figshare.1409398.v296
title: ABO phenotype protected reproduction as it is based on fucosylations.

description: The molecular biological relationship between human fertility and the formation of the ABO(H) blood group phenotype is evident in the rare (Oh) or <i>Bombay</i> blood type, which, based on the history of his own family, the <i>Darwin/Wedgewood Dynasty</i>, Charles Darwin would have interpreted as resulting from reduced fertility in consanguinities. In its native form, the <i>Bombay</i> type occurs in individuals with an extremely rare genotype (h/h;se/se), in whom the fucosyltransferases FUT1 and FUT2 are not produced due to point mutations. These enzymes, which are encoded on chromosome 19, are epistatically connected with the A and B allelic glycotransferase functions encoded on chromosome 9, and the fucosyl residues provide the functional-structural basis for the formation of any ABO(H) phenotype on the cell surface or in secretions and plasma proteins. Immunoglobulins are also heavily fucosylated, and fucosyl residues appear, via developmental variations in their positions on cell surfaces and on the heavy chains of immunoglobulins, to increase or reduce antibody-mediated cellular cytotoxicity involving physiological anti-self-reactivity; moreover, by regulating the assembly and intracellular signalling of precursor B cell receptors, the core fucosylation of immunoglobulin heavy chains represents a key mechanism in clonal selection. In fact, the seminal plasma of leukospermic infertile men has been reported to exhibit high levels of poorly core-fucosylated IgG. Thus, when antibody-dependent cellular cytotoxicity can be increased 50-fold simply by removing the single fucose residue from the Fc glycan, in <i>Bombay </i>type individuals, the non-somatic glycosylation processes of embryogenic stem cell-to-germ cell transformation are most likely exposed to metabolic competition with multiple glycosidic sites of poorly fucosylated, glycan-depleted immunoglobulins, suggesting to promote anti-self-reactive cellular cytotoxicity in male gamete performance.
DOI: 10.6084/m9.figshare.1394941
title: Managing the Challenges of Modern Research Surveys

description: One of the most pervasive tools in empirical research is the survey. Historically, surveys have been central to social science and psychology research. Survey methodologies are rapidly evolving with the rise of computerized technologies. Online survey websites and smartphones in particular facilitate faster and cheaper collection of survey data. But these new opportunities come at a cost: faster and cheaper surveying demands greater attention be paid to data integrity issues. Prometheus's Research Exchange Database (RexDB) offers a highly customizable software platform suited to manage survey data for research.
DOI: 10.6084/m9.figshare.1394944
title: Does the mamastrovirus 5 cause gastroenteritis in dogs? MastV5 ORF2 nucleotide tree

description: Evolutionary relationship of MAstV5 with representative MAstV genera. The percentage of replicates in which the associated virus clustered together in the bootstrap test (1000 replicates) is shown next to the branches in each tree. The trees are drawn to scale; bars represent the number of substitutions per site. All positions except ambiguous positions were included. GenBank accession numbers are shown on the tree. Evolutionary tree based on the partial nucleotide sequences of the ORF2 of 65 sequences of MAstV5. The samples obtained in the present study are highlighted with a symbol (bold).
DOI: 10.6084/m9.figshare.1394941.v1
title: Managing the Challenges of Modern Research Surveys

description: One of the most pervasive tools in empirical research is the survey. Historically, surveys have been central to social science and psychology research. Survey methodologies are rapidly evolving with the rise of computerized technologies. Online survey websites and smartphones in particular facilitate faster and cheaper collection of survey data. But these new opportunities come at a cost: faster and cheaper surveying demands greater attention be paid to data integrity issues. Prometheus's Research Exchange Database (RexDB) offers a highly customizable software platform suited to manage survey data for research.
DOI: 10.6084/m9.figshare.1394944.v2
title: Does the mamastrovirus 5 cause gastroenteritis in dogs? MastV5 ORF2 nucleotide tree

description: Evolutionary relationship of MAstV5 with representative MAstV genera. The percentage of replicates in which the associated virus clustered together in the bootstrap test (1000 replicates) is shown next to the branches in each tree. The trees are drawn to scale; bars represent the number of substitutions per site. All positions except ambiguous positions were included. GenBank accession numbers are shown on the tree. Evolutionary tree based on the partial nucleotide sequences of the ORF2 of 65 sequences of MAstV5. The samples obtained in the present study are highlighted with a symbol (bold).
DOI: 10.6084/m9.figshare.1394939
title: Exploring the Challenges and Opportunities of Leveraging EHRs for Data-Driven Clinical Research

description: Electronic health records (EHRs) can facilitate faster and cheaper clinical research investigations. By collecting diagnostic, intervention, and outcomes data at all levels of care and across time, EHRs capture a richer picture of clinical effects, relationships, efficiency, and more. With increased clinical reliance on EHR systems, the question remains of how to best leverage EHR data for research purposes.
DOI: 10.6084/m9.figshare.1394955.v2
title: Does the mamastrovirus 5 cause gastroenteritis in dogs? MAstVs ORF2 aminoacid tree

description: Evolutionary relationship of MAstV5 with representative MAstV genera. The percentage of replicates in which the associated virus clustered together in the bootstrap test (1000 replicates) is shown next to the branches in each tree. The trees are drawn to scale; bars represent the number of substitutions per site. All positions except ambiguous positions were included. GenBank accession numbers are shown on the tree. Evolutionary tree based on the partial nucleotide sequences of the ORF2 of 65 sequences of MAstV5. The samples obtained in the present study are highlighted with a symbol (bold).
DOI: 10.6084/m9.figshare.1409398.v297
title: ABO phenotype protected reproduction as it is based on fucosylations.

description: The molecular biological relationship between human fertility and the formation of the ABO(H) blood group phenotype is evident in the rare (Oh) or <i>Bombay</i> blood type, which, based on the history of his own family, the <i>Darwin/Wedgewood Dynasty</i>, Charles Darwin would have interpreted as resulting from reduced fertility in consanguinities. In its native form, the <i>Bombay</i> type occurs in individuals with an extremely rare genotype (h/h;se/se), in whom the fucosyltransferases FUT1 and FUT2 are not produced due to point mutations. These enzymes, which are encoded on chromosome 19, are epistatically connected with the A and B allelic glycotransferase functions encoded on chromosome 9, and the fucosyl residues provide the functional-structural basis for the formation of any ABO(H) phenotype on the cell surface or in secretions and plasma proteins. Immunoglobulins are also heavily fucosylated, and fucosyl residues appear, via developmental variations in their positions on cell surfaces and on the heavy chains of immunoglobulins, to increase or reduce antibody-mediated cellular cytotoxicity involving physiological anti-self-reactivity; moreover, by regulating the assembly and intracellular signalling of precursor B cell receptors, the core fucosylation of immunoglobulin heavy chains represents a key mechanism in clonal selection. In fact, the seminal plasma of leukospermic infertile men has been reported to exhibit high levels of poorly core-fucosylated IgG. Thus, when antibody-dependent cellular cytotoxicity can be increased 50-fold simply by removing the single fucose residue from the Fc glycan, in <i>Bombay </i>type individuals, the non-somatic glycosylation processes of embryogenic stem cell-to-germ cell transformation are most likely exposed to metabolic competition with multiple glycosidic sites of poorly fucosylated, glycan-depleted immunoglobulins, suggesting to promote anti-self-reactive cellular cytotoxicity in male gamete performance.
DOI: 10.6084/m9.figshare.1394944.v1
title: MastV5 ORF2 nucleotide tree

description: Evolutionary relationship of MAstV5 with representative MAstV genera. The percentage of replicates in which the associated virus clustered together in the bootstrap test (1000 replicates) is shown next to the branches in each tree. The trees are drawn to scale; bars represent the number of substitutions per site. All positions except ambiguous positions were included. GenBank accession numbers are shown on the tree. Evolutionary tree based on the partial nucleotide sequences of the ORF2 of 65 sequences of MAstV5. The samples obtained in the present study are highlighted with a symbol (bold).