DOI: 10.7270/q2rv0s0k
title: BindingDB Entry 50007029: Structure-based rational design of staurosporine-based fluorescent probe with broad-ranging kinase affinity for kinase panel application.

description: Small molecule binding data for protein 3-phosphoinositide-dependent protein kinase 1, 5'-AMP-activated protein kinase catalytic subunit alpha-1/subunit beta-1/subunit gamma-1, 5'-AMP-activated protein kinase catalytic subunit alpha-2, ALK tyrosine kinase receptor, AP2-associated protein kinase 1, Activated CDC42 kinase 1, Angiopoietin-1 receptor, Aurora kinase A, BMP-2-inducible protein kinase, CDK-activating kinase assembly factor MAT1/Cyclin-H/Cyclin-dependent kinase 7, Calcium/calmodulin-dependent protein kinase kinase 1, Calcium/calmodulin-dependent protein kinase kinase 2, Calcium/calmodulin-dependent protein kinase type 1G, Calcium/calmodulin-dependent protein kinase type II subunit alpha, Calcium/calmodulin-dependent protein kinase type II subunit beta, Calcium/calmodulin-dependent protein kinase type II subunit delta, Calcium/calmodulin-dependent protein kinase type II subunit gamma, Citron Rho-interacting kinase, Cyclin-A2/Cyclin-dependent kinase 2, Cyclin-C/Cyclin-dependent kinase 19, Cyclin-T1/Cyclin-dependent kinase 9, Cyclin-dependent kinase 5 activator 1, Cytoplasmic tyrosine-protein kinase BMX, Death-associated protein kinase 1, Death-associated protein kinase 2, Death-associated protein kinase 3, Dual specificity mitogen-activated protein kinase kinase 1, Dual specificity mitogen-activated protein kinase kinase 6, Dual specificity mitogen-activated protein kinase kinase 7, Dual specificity protein kinase CLK1, Dual specificity protein kinase CLK2, Dual specificity protein kinase CLK4, Dual specificity tyrosine-phosphorylation-regulated kinase 1A, Dual specificity tyrosine-phosphorylation-regulated kinase 1B, Ephrin type-A receptor 1, Ephrin type-A receptor 3, Ephrin type-A receptor 4, Ephrin type-A receptor 7, Ephrin type-A receptor 8, Ephrin type-B receptor 2, Ephrin type-B receptor 4, Ephrin type-B receptor 6, Epithelial discoidin domain-containing receptor 1, Fibroblast growth factor receptor 1, Fibroblast growth factor receptor 2, Fibroblast growth factor receptor 3, Fibroblast growth factor receptor 4, Focal adhesion kinase 1, Glycogen synthase kinase-3 alpha, Glycogen synthase kinase-3 beta, Hepatocyte growth factor receptor, High affinity nerve growth factor receptor, Homeodomain-interacting protein kinase 2, Homeodomain-interacting protein kinase 3, Homeodomain-interacting protein kinase 4, Inhibitor of nuclear factor kappa-B kinase subunit epsilon, Insulin receptor, Interleukin-1 receptor-associated kinase 1, Interleukin-1 receptor-associated kinase 4, LIM domain kinase 1, Leukocyte tyrosine kinase receptor, MAP kinase-interacting serine/threonine-protein kinase 2, MAP/microtubule affinity-regulating kinase 3, MAP/microtubule affinity-regulating kinase 4, Macrophage colony-stimulating factor 1 receptor, Maternal embryonic leucine zipper kinase, Misshapen-like kinase 1, Mitogen-activated protein kinase 10, Mitogen-activated protein kinase 12, Mitogen-activated protein kinase 15, Mitogen-activated protein kinase 8, Mitogen-activated protein kinase 9, Mitogen-activated protein kinase kinase kinase 11, Mitogen-activated protein kinase kinase kinase 14, Mitogen-activated protein kinase kinase kinase 2, Mitogen-activated protein kinase kinase kinase 5, Mitogen-activated protein kinase kinase kinase 7, Mitogen-activated protein kinase kinase kinase 9, Mitogen-activated protein kinase kinase kinase kinase 1, Mitogen-activated protein kinase kinase kinase kinase 2, Mitogen-activated protein kinase kinase kinase kinase 5, Myosin light chain kinase 3, Myosin light chain kinase, smooth muscle, Myosin-IIIb, Myotonin-protein kinase, NT-3 growth factor receptor, NUAK family SNF1-like kinase 1, NUAK family SNF1-like kinase 2, Non-receptor tyrosine-protein kinase TNK1, Non-receptor tyrosine-protein kinase TYK2, Peripheral plasma membrane protein CASK, Phosphorylase b kinase gamma catalytic chain, liver/testis isoform, Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform, Platelet-derived growth factor receptor beta, Protein kinase C alpha type, Protein kinase C beta type, Protein kinase C delta type, Protein kinase C epsilon type, Protein kinase C eta type, Protein kinase C gamma type, Protein kinase C iota type, Protein kinase C theta type, Protein kinase C zeta type, Protein-tyrosine kinase 2-beta, Proto-oncogene tyrosine-protein kinase ROS, Proto-oncogene tyrosine-protein kinase Src, Proto-oncogene tyrosine-protein kinase receptor Ret, RAC-beta serine/threonine-protein kinase, RAC-gamma serine/threonine-protein kinase, Receptor tyrosine-protein kinase erbB-4, Rho-associated protein kinase 1, Rho-associated protein kinase 2, Rhodopsin kinase GRK1, Ribosomal protein S6 kinase alpha-1, Ribosomal protein S6 kinase alpha-2, Ribosomal protein S6 kinase alpha-3, Ribosomal protein S6 kinase alpha-5, Ribosomal protein S6 kinase alpha-6, Ribosomal protein S6 kinase beta-1, STE20-like serine/threonine-protein kinase, Serine/threonine-protein kinase 16, Serine/threonine-protein kinase 17A, Serine/threonine-protein kinase 24, Serine/threonine-protein kinase 25, Serine/threonine-protein kinase 26, Serine/threonine-protein kinase 3, Serine/threonine-protein kinase 32A, Serine/threonine-protein kinase 32B, Serine/threonine-protein kinase 32C, Serine/threonine-protein kinase 33, Serine/threonine-protein kinase 38-like, Serine/threonine-protein kinase 4, Serine/threonine-protein kinase BRSK1, Serine/threonine-protein kinase Chk1, Serine/threonine-protein kinase Chk2, Serine/threonine-protein kinase D2, Serine/threonine-protein kinase DCLK3, Serine/threonine-protein kinase LATS2, Serine/threonine-protein kinase MARK1, Serine/threonine-protein kinase MARK2, Serine/threonine-protein kinase MRCK alpha, Serine/threonine-protein kinase MRCK gamma, Serine/threonine-protein kinase N1, Serine/threonine-protein kinase N2, Serine/threonine-protein kinase PAK 4, Serine/threonine-protein kinase PAK 5, Serine/threonine-protein kinase PAK 6, Serine/threonine-protein kinase PLK4, Serine/threonine-protein kinase SIK1, Serine/threonine-protein kinase SIK2, Serine/threonine-protein kinase SIK3, Serine/threonine-protein kinase Sgk1, Serine/threonine-protein kinase Sgk2, Serine/threonine-protein kinase Sgk3, Serine/threonine-protein kinase TAO1, Serine/threonine-protein kinase TAO3, Serine/threonine-protein kinase TBK1, Serine/threonine-protein kinase TNNI3K, Serine/threonine-protein kinase ULK1, Serine/threonine-protein kinase ULK2, Serine/threonine-protein kinase ULK3, Serine/threonine-protein kinase pim-1, Serine/threonine-protein kinase pim-2, Serine/threonine-protein kinase pim-3, TGF-beta receptor type-2, TRAF2 and NCK-interacting protein kinase, Testis-specific serine/threonine-protein kinase 1, Testis-specific serine/threonine-protein kinase 3, Tyrosine-protein kinase ABL1, Tyrosine-protein kinase ABL2, Tyrosine-protein kinase BTK, Tyrosine-protein kinase Blk, Tyrosine-protein kinase CSK, Tyrosine-protein kinase FRK, Tyrosine-protein kinase Fer, Tyrosine-protein kinase Fes/Fps, Tyrosine-protein kinase Fgr, Tyrosine-protein kinase Fyn, Tyrosine-protein kinase HCK, Tyrosine-protein kinase ITK/TSK, Tyrosine-protein kinase JAK2, Tyrosine-protein kinase JAK3, Tyrosine-protein kinase Lck, Tyrosine-protein kinase Lyn, Tyrosine-protein kinase Mer, Tyrosine-protein kinase SYK, Tyrosine-protein kinase TXK, Tyrosine-protein kinase Tec, Tyrosine-protein kinase Yes, Tyrosine-protein kinase ZAP-70, Tyrosine-protein kinase receptor TYRO3, Tyrosine-protein kinase receptor UFO, Vascular endothelial growth factor receptor 2, Vascular endothelial growth factor receptor 3, [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial, cAMP-dependent protein kinase catalytic subunit PRKX, cAMP-dependent protein kinase catalytic subunit alpha, cAMP-dependent protein kinase catalytic subunit beta, cAMP-dependent protein kinase catalytic subunit gamma, cGMP-dependent protein kinase 1, and cGMP-dependent protein kinase 2, Uniprot O00141, O00444, O00506, O14578, O14733, O14757, O14936, O14965, O15197, O15530, O43293, O43318, O60285, O60563, O60674, O75116, O75385, O75582, O75716, O96013, O96017, P00519, P04629, P05129, P05771, P06213, P06239, P06241, P07332, P07333, P07947, P07948, P07949, P08581, P08631, P08922, P09619, P09769, P11309, P11362, P12931, P15735, P16591, P17252, P17612, P20248, P21709, P21802, P22455, P22607, P22612, P22694, P23443, P24723, P24863, P24941, P27448, P29320, P29322, P29323, P29376, P29597, P30530, P31751, P35916, P35968, P37173, P41240, P41743, P42680, P42681, P42684, P42685, P43403, P43405, P45983, P45984, P49759, P49760, P49840, P49841, P50613, P50750, P51451, P51617, P51812, P51813, P51817, P51946, P51948, P52333, P52564, P53355, P53667, P53778, P53779, P54619, P54646, P54760, P54764, P57059, P80192, Q00535, Q02156, Q02750, Q02763, Q04759, Q05397, Q05513, Q05655, Q06187, Q06418, Q07912, Q08345, Q08881, Q09013, Q12851, Q12866, Q13043, Q13131, Q13188, Q13237, Q13464, Q13470, Q13554, Q13555, Q13557, Q13627, Q13976, Q14164, Q14289, Q14680, Q15078, Q15118, Q15303, Q15349, Q15375, Q15418, Q15746, Q15835, Q16288, Q16512, Q16513, Q16584, Q16816, Q2M2I8, Q32MK0, Q59H18, Q5VT25, Q6DT37, Q6PHR2, Q7KZI7, Q7L7X3, Q86UX6, Q86V86, Q8IYT8, Q8N4C8, Q8N5S9, Q8NE63, Q8TD08, Q8TDC3, Q8WU08, Q8WXR4, Q92918, Q96BR1, Q96L34, Q96NX5, Q96PN8, Q96RR4, Q99558, Q99683, Q9BWU1, Q9BXA7, Q9BYT3, Q9BZL6, Q9C098, Q9H093, Q9H0K1, Q9H2G2, Q9H2K8, Q9H2X6, Q9H422, Q9HAZ1, Q9HBH9, Q9HBY8, Q9NQU5, Q9NRM7, Q9NSY1, Q9NWZ3, Q9NY57, Q9P0L2, Q9P1W9, Q9P286, Q9P289, Q9UEE5, Q9UHD2, Q9UIK4, Q9UK32, Q9UKE5, Q9UM73, Q9UQM7, Q9Y243, Q9Y2H1, Q9Y2K2, Q9Y2U5, Q9Y463, Q9Y478, Q9Y4K4, and Q9Y6E0