cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.15657393.v1
title: Supplementary Material for: Use of Liraglutide 3.0 mg for Weight Management in a Real-World Setting in Switzerland

description: <b><i>Introduction:</i></b> Data from randomized controlled trials show that liraglutide 3.0 mg, in combination with diet and exercise, is associated with greater weight loss than diet and exercise alone in patients with obesity. In practice, the utilization of weight loss drugs is influenced by various factors, including the cost of treatment. We conducted a retrospective, observational study to assess the effectiveness of liraglutide 3.0 mg and patients’ persistence on treatment, in a real-world setting. <b><i>Methods:</i></b> Data were extracted from de-identified electronic medical records from an obesity management clinic in Switzerland. Changes in body weight and blood pressure were evaluated in the full cohort (<i>N</i> = 277, 19% of whom had undergone bariatric surgery) and subgroups who were persistent on liraglutide 3.0 mg for at least 4 months (<i>n</i> = 236), 7 months (<i>n</i> = 159), or 12 months (<i>n</i> = 71). <b><i>Results:</i></b> Median persistence on liraglutide was 6.8 months. Median maximum dose received was 1.5 mg, and 13.7% of patients reached the maintenance dose of 3.0 mg. Mean 7-month weight change from baseline in the full cohort was −4.1 kg (95% confidence interval: −5.0, −3.2; <i>p</i> &lt; 0.001; −4.2%). Weight change was −4.4 kg (−4.7%) in the ≥4-month persistence subgroup at 4 months, −5.1 kg (−5.3%) in the ≥7-month persistence subgroup at 7 months, and −7.5 kg (−7.1%) in the ≥12-month persistence subgroup at 12 months (all <i>p</i> &lt; 0.001). In the full cohort, 40% and 14% of patients lost ≥5% and &gt;10% of body weight at 7 months, respectively. Weight loss did not differ significantly according to history of bariatric surgery (<i>p</i> = 0.94). Diastolic blood pressure decreased (from 87.0 to 83.9 mm Hg at 7 months; <i>p</i> = 0.018), with no significant changes in systolic blood pressure. Approximately two-thirds of patients did not have health insurance that could cover the cost of liraglutide. <b><i>Conclusion:</i></b> In a real-world setting with low insurance coverage and with most patients not reaching the recommended maintenance dose of 3.0 mg, the use of liraglutide, in combination with diet and exercise, was associated with clinically meaningful weight loss.
DOI: 10.6084/m9.figshare.15658983
title: 2006-11-14 14-39 Lake Rotokakahi (Green Lake)

description: A CTD cast on Lake Rotokakahi<br><br><b>Quality control:</b> Calibration; Model; Sensor height (m)<br><br><b>Type of waterbody:</b> Lake<br><br><b>Variables:</b> Beam Transmission; Chlorophyll Fluorescence; Conductivity; Dissolved Oxygen Concentration; Dissolved Oxygen Saturation; Photosynthetically Active Radiation; Salinity; Specific Conductance; Water Temperature<br><br><b>Start date:</b> 2006-11-14<br><br><b>End date:</b> 2006-11-14<br><br><b>Lake:</b> Lake Rotokakahi/Green Lake<br><br><b>Region:</b> Bay of Plenty<br><br>This dataset was originally hosted in the LERNZdb freshwater data repository that was developed as part of the Lake Ecosystem Restoration New Zealand (LERNZ) project run by the Environmental Research Institute at the University of Waikato, New Zealand. <br><br>In retrieving LERNZdb material you agree that you rely on the data at your own risk; the University of Waikato offers no warranty or representation that the data is fit for any particular purpose, or free from defects, and will not be liable for any losses or damages whatsoever including any indirect, special, incidental or consequential damages incurred by you arising out of the use of the database or in reliance on the data retrieved. You agree that data is not of a kind ordinarily supplied for personal or domestic purposes, and that the Consumer Guarantees Act 1993 does not apply.
DOI: 10.6084/m9.figshare.15658983.v1
title: 2006-11-14 14-39 Lake Rotokakahi (Green Lake)

description: A CTD cast on Lake Rotokakahi<br><br><b>Quality control:</b> Calibration; Model; Sensor height (m)<br><br><b>Type of waterbody:</b> Lake<br><br><b>Variables:</b> Beam Transmission; Chlorophyll Fluorescence; Conductivity; Dissolved Oxygen Concentration; Dissolved Oxygen Saturation; Photosynthetically Active Radiation; Salinity; Specific Conductance; Water Temperature<br><br><b>Start date:</b> 2006-11-14<br><br><b>End date:</b> 2006-11-14<br><br><b>Lake:</b> Lake Rotokakahi/Green Lake<br><br><b>Region:</b> Bay of Plenty<br><br>This dataset was originally hosted in the LERNZdb freshwater data repository that was developed as part of the Lake Ecosystem Restoration New Zealand (LERNZ) project run by the Environmental Research Institute at the University of Waikato, New Zealand. <br><br>In retrieving LERNZdb material you agree that you rely on the data at your own risk; the University of Waikato offers no warranty or representation that the data is fit for any particular purpose, or free from defects, and will not be liable for any losses or damages whatsoever including any indirect, special, incidental or consequential damages incurred by you arising out of the use of the database or in reliance on the data retrieved. You agree that data is not of a kind ordinarily supplied for personal or domestic purposes, and that the Consumer Guarantees Act 1993 does not apply.
DOI: 10.6084/m9.figshare.15659106
title: 2006-11-14 14-47 Lake Rotokakahi (Green Lake)

description: A CTD cast on Lake Rotokakahi<br><br><b>Quality control:</b> Calibration; Model; Sensor height (m)<br><br><b>Type of waterbody:</b> Lake<br><br><b>Variables:</b> Beam Transmission; Chlorophyll Fluorescence; Conductivity; Dissolved Oxygen Concentration; Dissolved Oxygen Saturation; Photosynthetically Active Radiation; Salinity; Specific Conductance; Water Temperature<br><br><b>Start date:</b> 2006-11-14<br><br><b>End date:</b> 2006-11-14<br><br><b>Lake:</b> Lake Rotokakahi/Green Lake<br><br><b>Region:</b> Bay of Plenty<br><br>This dataset was originally hosted in the LERNZdb freshwater data repository that was developed as part of the Lake Ecosystem Restoration New Zealand (LERNZ) project run by the Environmental Research Institute at the University of Waikato, New Zealand. <br><br>In retrieving LERNZdb material you agree that you rely on the data at your own risk; the University of Waikato offers no warranty or representation that the data is fit for any particular purpose, or free from defects, and will not be liable for any losses or damages whatsoever including any indirect, special, incidental or consequential damages incurred by you arising out of the use of the database or in reliance on the data retrieved. You agree that data is not of a kind ordinarily supplied for personal or domestic purposes, and that the Consumer Guarantees Act 1993 does not apply.
DOI: 10.6084/m9.figshare.15659106.v1
title: 2006-11-14 14-47 Lake Rotokakahi (Green Lake)

description: A CTD cast on Lake Rotokakahi<br><br><b>Quality control:</b> Calibration; Model; Sensor height (m)<br><br><b>Type of waterbody:</b> Lake<br><br><b>Variables:</b> Beam Transmission; Chlorophyll Fluorescence; Conductivity; Dissolved Oxygen Concentration; Dissolved Oxygen Saturation; Photosynthetically Active Radiation; Salinity; Specific Conductance; Water Temperature<br><br><b>Start date:</b> 2006-11-14<br><br><b>End date:</b> 2006-11-14<br><br><b>Lake:</b> Lake Rotokakahi/Green Lake<br><br><b>Region:</b> Bay of Plenty<br><br>This dataset was originally hosted in the LERNZdb freshwater data repository that was developed as part of the Lake Ecosystem Restoration New Zealand (LERNZ) project run by the Environmental Research Institute at the University of Waikato, New Zealand. <br><br>In retrieving LERNZdb material you agree that you rely on the data at your own risk; the University of Waikato offers no warranty or representation that the data is fit for any particular purpose, or free from defects, and will not be liable for any losses or damages whatsoever including any indirect, special, incidental or consequential damages incurred by you arising out of the use of the database or in reliance on the data retrieved. You agree that data is not of a kind ordinarily supplied for personal or domestic purposes, and that the Consumer Guarantees Act 1993 does not apply.
DOI: 10.6084/m9.figshare.15659187.v1
title: 2006-11-14 14-55 Lake Rotokakahi (Green Lake)

description: A CTD cast on Lake Rotokakahi<br><br><b>Quality control:</b> Calibration; Model; Sensor height (m)<br><br><b>Type of waterbody:</b> Lake<br><br><b>Variables:</b> Beam Transmission; Chlorophyll Fluorescence; Conductivity; Dissolved Oxygen Concentration; Dissolved Oxygen Saturation; Photosynthetically Active Radiation; Salinity; Specific Conductance; Water Temperature<br><br><b>Start date:</b> 2006-11-14<br><br><b>End date:</b> 2006-11-14<br><br><b>Lake:</b> Lake Rotokakahi/Green Lake<br><br><b>Region:</b> Bay of Plenty<br><br>This dataset was originally hosted in the LERNZdb freshwater data repository that was developed as part of the Lake Ecosystem Restoration New Zealand (LERNZ) project run by the Environmental Research Institute at the University of Waikato, New Zealand. <br><br>In retrieving LERNZdb material you agree that you rely on the data at your own risk; the University of Waikato offers no warranty or representation that the data is fit for any particular purpose, or free from defects, and will not be liable for any losses or damages whatsoever including any indirect, special, incidental or consequential damages incurred by you arising out of the use of the database or in reliance on the data retrieved. You agree that data is not of a kind ordinarily supplied for personal or domestic purposes, and that the Consumer Guarantees Act 1993 does not apply.
DOI: 10.6084/m9.figshare.15659187
title: 2006-11-14 14-55 Lake Rotokakahi (Green Lake)

description: A CTD cast on Lake Rotokakahi<br><br><b>Quality control:</b> Calibration; Model; Sensor height (m)<br><br><b>Type of waterbody:</b> Lake<br><br><b>Variables:</b> Beam Transmission; Chlorophyll Fluorescence; Conductivity; Dissolved Oxygen Concentration; Dissolved Oxygen Saturation; Photosynthetically Active Radiation; Salinity; Specific Conductance; Water Temperature<br><br><b>Start date:</b> 2006-11-14<br><br><b>End date:</b> 2006-11-14<br><br><b>Lake:</b> Lake Rotokakahi/Green Lake<br><br><b>Region:</b> Bay of Plenty<br><br>This dataset was originally hosted in the LERNZdb freshwater data repository that was developed as part of the Lake Ecosystem Restoration New Zealand (LERNZ) project run by the Environmental Research Institute at the University of Waikato, New Zealand. <br><br>In retrieving LERNZdb material you agree that you rely on the data at your own risk; the University of Waikato offers no warranty or representation that the data is fit for any particular purpose, or free from defects, and will not be liable for any losses or damages whatsoever including any indirect, special, incidental or consequential damages incurred by you arising out of the use of the database or in reliance on the data retrieved. You agree that data is not of a kind ordinarily supplied for personal or domestic purposes, and that the Consumer Guarantees Act 1993 does not apply.
DOI: 10.6084/m9.figshare.15657495
title: Supplementary Material for: The Expression Profile of Protease Inhibitors in the Airway Epithelial Cells after Allergen (Der p 1) Stimulation

description: <b><i>Background:</i></b> Airway epithelial cells are constantly exposed to intracellular and extracellular proteases that play a pivotal role in several airway diseases. <i>Dermatophagoides pteronyssinus</i> (Der p) 1 derived from house dust mite has protease activity that causes epithelial barrier defect and inflammatory response. Protease inhibitors released against proteases are involved in the maintenance of homeostasis. A disruption of the balance between proteases and protease inhibitors can lead to distortion of the cellular structures and cellular activities and thus culminate in disease processes. Although the effects of Der p 1 allergen on epithelial barrier integrity and inflammatory response are well-established, its contribution to protease inhibitor production is highly limited. <b><i>Objective:</i></b> This study aimed to determine the profile of the protease inhibitor response to Der p 1 allergen in human airway epithelial cells, A549 and BEAS-2B. <b><i>Methods:</i></b> Differentiated cells by the air-liquid interface were exposed to Der p 1 with or without Th2 type cytokines (IL-4 and IL-13). Gene expression of protease inhibitors was determined by qPCR at 2 different time points. <b><i>Results:</i></b> We found that the effect of allergen exposure on the protease inhibitor profile can vary depending on the antigen concentration, treatment duration, and the presence or absence of type 2 cytokines. Gene expressions of serine protease inhibitor (<i>SERPIN</i>)<i>B3</i> and <i>SERPINB4</i> were increased following Th2 cytokine stimulation in both cell types at both time points, whereas <i>SERPINB2</i> and <i>TFPI-2</i> expressions were induced by 24-h Der p 1 stimulation in both cells. <b><i>Conclusions:</i></b> Our study suggests that Der p 1 exposure of the airway epithelium may have consequences related to its protease activity in the presence as well as in the absence of Th2 cytokines in the microenvironment.
DOI: 10.6084/m9.figshare.15657495.v1
title: Supplementary Material for: The Expression Profile of Protease Inhibitors in the Airway Epithelial Cells after Allergen (Der p 1) Stimulation

description: <b><i>Background:</i></b> Airway epithelial cells are constantly exposed to intracellular and extracellular proteases that play a pivotal role in several airway diseases. <i>Dermatophagoides pteronyssinus</i> (Der p) 1 derived from house dust mite has protease activity that causes epithelial barrier defect and inflammatory response. Protease inhibitors released against proteases are involved in the maintenance of homeostasis. A disruption of the balance between proteases and protease inhibitors can lead to distortion of the cellular structures and cellular activities and thus culminate in disease processes. Although the effects of Der p 1 allergen on epithelial barrier integrity and inflammatory response are well-established, its contribution to protease inhibitor production is highly limited. <b><i>Objective:</i></b> This study aimed to determine the profile of the protease inhibitor response to Der p 1 allergen in human airway epithelial cells, A549 and BEAS-2B. <b><i>Methods:</i></b> Differentiated cells by the air-liquid interface were exposed to Der p 1 with or without Th2 type cytokines (IL-4 and IL-13). Gene expression of protease inhibitors was determined by qPCR at 2 different time points. <b><i>Results:</i></b> We found that the effect of allergen exposure on the protease inhibitor profile can vary depending on the antigen concentration, treatment duration, and the presence or absence of type 2 cytokines. Gene expressions of serine protease inhibitor (<i>SERPIN</i>)<i>B3</i> and <i>SERPINB4</i> were increased following Th2 cytokine stimulation in both cell types at both time points, whereas <i>SERPINB2</i> and <i>TFPI-2</i> expressions were induced by 24-h Der p 1 stimulation in both cells. <b><i>Conclusions:</i></b> Our study suggests that Der p 1 exposure of the airway epithelium may have consequences related to its protease activity in the presence as well as in the absence of Th2 cytokines in the microenvironment.
DOI: 10.6084/m9.figshare.15659274.v1
title: 2006-11-14 15-06 Lake Rotokakahi (Green Lake)

description: A CTD cast on Lake Rotokakahi<br><br><b>Quality control:</b> Calibration; Model; Sensor height (m)<br><br><b>Type of waterbody:</b> Lake<br><br><b>Variables:</b> Beam Transmission; Chlorophyll Fluorescence; Conductivity; Dissolved Oxygen Concentration; Dissolved Oxygen Saturation; Photosynthetically Active Radiation; Salinity; Specific Conductance; Water Temperature<br><br><b>Start date:</b> 2006-11-14<br><br><b>End date:</b> 2006-11-14<br><br><b>Lake:</b> Lake Rotokakahi/Green Lake<br><br><b>Region:</b> Bay of Plenty<br><br>This dataset was originally hosted in the LERNZdb freshwater data repository that was developed as part of the Lake Ecosystem Restoration New Zealand (LERNZ) project run by the Environmental Research Institute at the University of Waikato, New Zealand. <br><br>In retrieving LERNZdb material you agree that you rely on the data at your own risk; the University of Waikato offers no warranty or representation that the data is fit for any particular purpose, or free from defects, and will not be liable for any losses or damages whatsoever including any indirect, special, incidental or consequential damages incurred by you arising out of the use of the database or in reliance on the data retrieved. You agree that data is not of a kind ordinarily supplied for personal or domestic purposes, and that the Consumer Guarantees Act 1993 does not apply.
DOI: 10.6084/m9.figshare.15659274
title: 2006-11-14 15-06 Lake Rotokakahi (Green Lake)

description: A CTD cast on Lake Rotokakahi<br><br><b>Quality control:</b> Calibration; Model; Sensor height (m)<br><br><b>Type of waterbody:</b> Lake<br><br><b>Variables:</b> Beam Transmission; Chlorophyll Fluorescence; Conductivity; Dissolved Oxygen Concentration; Dissolved Oxygen Saturation; Photosynthetically Active Radiation; Salinity; Specific Conductance; Water Temperature<br><br><b>Start date:</b> 2006-11-14<br><br><b>End date:</b> 2006-11-14<br><br><b>Lake:</b> Lake Rotokakahi/Green Lake<br><br><b>Region:</b> Bay of Plenty<br><br>This dataset was originally hosted in the LERNZdb freshwater data repository that was developed as part of the Lake Ecosystem Restoration New Zealand (LERNZ) project run by the Environmental Research Institute at the University of Waikato, New Zealand. <br><br>In retrieving LERNZdb material you agree that you rely on the data at your own risk; the University of Waikato offers no warranty or representation that the data is fit for any particular purpose, or free from defects, and will not be liable for any losses or damages whatsoever including any indirect, special, incidental or consequential damages incurred by you arising out of the use of the database or in reliance on the data retrieved. You agree that data is not of a kind ordinarily supplied for personal or domestic purposes, and that the Consumer Guarantees Act 1993 does not apply.
DOI: 10.6084/m9.figshare.15659334
title: 2006-11-14 16-45 Lake Rotokakahi (Green Lake)

description: A CTD cast on Lake Rotokakahi<br><br><b>Quality control:</b> Calibration; Model; Sensor height (m)<br><br><b>Type of waterbody:</b> Lake<br><br><b>Variables:</b> Beam Transmission; Chlorophyll Fluorescence; Conductivity; Dissolved Oxygen Concentration; Dissolved Oxygen Saturation; Photosynthetically Active Radiation; Salinity; Specific Conductance; Water Temperature<br><br><b>Start date:</b> 2006-11-14<br><br><b>End date:</b> 2006-11-14<br><br><b>Lake:</b> Lake Rotokakahi/Green Lake<br><br><b>Region:</b> Bay of Plenty<br><br>This dataset was originally hosted in the LERNZdb freshwater data repository that was developed as part of the Lake Ecosystem Restoration New Zealand (LERNZ) project run by the Environmental Research Institute at the University of Waikato, New Zealand. <br><br>In retrieving LERNZdb material you agree that you rely on the data at your own risk; the University of Waikato offers no warranty or representation that the data is fit for any particular purpose, or free from defects, and will not be liable for any losses or damages whatsoever including any indirect, special, incidental or consequential damages incurred by you arising out of the use of the database or in reliance on the data retrieved. You agree that data is not of a kind ordinarily supplied for personal or domestic purposes, and that the Consumer Guarantees Act 1993 does not apply.
DOI: 10.6084/m9.figshare.15659334.v1
title: 2006-11-14 16-45 Lake Rotokakahi (Green Lake)

description: A CTD cast on Lake Rotokakahi<br><br><b>Quality control:</b> Calibration; Model; Sensor height (m)<br><br><b>Type of waterbody:</b> Lake<br><br><b>Variables:</b> Beam Transmission; Chlorophyll Fluorescence; Conductivity; Dissolved Oxygen Concentration; Dissolved Oxygen Saturation; Photosynthetically Active Radiation; Salinity; Specific Conductance; Water Temperature<br><br><b>Start date:</b> 2006-11-14<br><br><b>End date:</b> 2006-11-14<br><br><b>Lake:</b> Lake Rotokakahi/Green Lake<br><br><b>Region:</b> Bay of Plenty<br><br>This dataset was originally hosted in the LERNZdb freshwater data repository that was developed as part of the Lake Ecosystem Restoration New Zealand (LERNZ) project run by the Environmental Research Institute at the University of Waikato, New Zealand. <br><br>In retrieving LERNZdb material you agree that you rely on the data at your own risk; the University of Waikato offers no warranty or representation that the data is fit for any particular purpose, or free from defects, and will not be liable for any losses or damages whatsoever including any indirect, special, incidental or consequential damages incurred by you arising out of the use of the database or in reliance on the data retrieved. You agree that data is not of a kind ordinarily supplied for personal or domestic purposes, and that the Consumer Guarantees Act 1993 does not apply.
DOI: 10.6084/m9.figshare.15659403
title: 2006-11-14 16-51 Lake Rotokakahi (Green Lake)

description: A CTD cast on Lake Rotokakahi<br><br><b>Quality control:</b> Calibration; Model; Sensor height (m)<br><br><b>Type of waterbody:</b> Lake<br><br><b>Variables:</b> Beam Transmission; Chlorophyll Fluorescence; Conductivity; Dissolved Oxygen Concentration; Dissolved Oxygen Saturation; Photosynthetically Active Radiation; Salinity; Specific Conductance; Water Temperature<br><br><b>Start date:</b> 2006-11-14<br><br><b>End date:</b> 2006-11-14<br><br><b>Lake:</b> Lake Rotokakahi/Green Lake<br><br><b>Region:</b> Bay of Plenty<br><br>This dataset was originally hosted in the LERNZdb freshwater data repository that was developed as part of the Lake Ecosystem Restoration New Zealand (LERNZ) project run by the Environmental Research Institute at the University of Waikato, New Zealand. <br><br>In retrieving LERNZdb material you agree that you rely on the data at your own risk; the University of Waikato offers no warranty or representation that the data is fit for any particular purpose, or free from defects, and will not be liable for any losses or damages whatsoever including any indirect, special, incidental or consequential damages incurred by you arising out of the use of the database or in reliance on the data retrieved. You agree that data is not of a kind ordinarily supplied for personal or domestic purposes, and that the Consumer Guarantees Act 1993 does not apply.