cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.21517524.v1
title: Clinician perspectives on the development of a web portal for remote monitoring of mHealth facilitated dysphagia home exercise: A qualitative study

description: Mobile health (mHealth) technologies for dysphagia management may allow patients to complete rehabilitation exercises from home and their clinicians to remotely monitor them. However, clinicians are rarely formally consulted in the early stages of ideation. This study aimed to determine necessary elements to be included in a clinician web portal that would allow for remote monitoring of patients completing dysphagia exercises using mHealth equipped with surface electromyography (sEMG). Ten dysphagia clinicians were consulted individually using convergent interviewing. Interviews were transcribed and analysed using thematic analysis to identify themes and sub-themes. Themes identified included: perceived benefits of an mHealth system; clinical uptake of an mHealth system; clinical targets desired; preferred communication method; notification style and frequency; and user interface considerations. There was no consensus regarding clinical targets to display, notification frequency, method of clinician-patient communication, or layout for the user interface. Agreement existed on the importance of the simplicity and customisability for the clinician web portal user interface. Lack of consensus on specific elements to be included in a clinician web portal could reflect low clinical exposure to sEMG. This study provides an example of formal end user feedback in the ideation phase of design.
DOI: 10.6084/m9.figshare.14515944.v1
title: Ecosystem organic carbon storage and their drivers across the drylands of China

description: Earth’s drylands store large amounts of organic carbon and thus play an important role in regulating atmospheric CO2 concentrations and mitigating climate change. However, little is known about the magnitude and the drivers of organic carbon stocks because of limited data, in particular in desert ecosystems. To fill this gap, we surveyed 763 plots and collected 5091 soil samples from 170 sites covering grassland and desert ecosystems across the drylands of China. The results show that 10.96 Pg organic carbon is stored in these ecosystems (7.07 Pg in grasslands and 3.89 Pg in deserts). The effects of environmental variables on carbon density were found to be contingent on ecosystem type and soil depth. Mean annual precipitation had a strong positive effect on the spatial distributions of vegetation carbon density in both types of ecosystems. The spatial variations of surface (0-40cm) and subsurface (40-100cm) soil organic carbon (SOC) density in grasslands were mainly correlated with plant productivity and mean annual temperature (MAT), respectively, while in desert ecosystems, they were mainly correlated with soil salinity (electrical conductivity). The spatial sensitivities (linear regression slopes) of the surface SOC density versus MAT increased from dry subhumid to semi-arid regions and then gradually shifted to decrease from semi-arid to hyper-arid regions, indicating that the surface SOC stock is more sensitive to temperature in semi-arid regions. This study provides a comprehensive survey of ecosystem carbon stocks in China’s drylands, fills a gap in our knowledge about carbon stocks in deserts, complements estimates of ecosystem carbon stocks throughout China, and provides insights into our understanding of the carbon cycle in drylands.
DOI: 10.6084/m9.figshare.28063049.v1
title: PubChemQC3M README

description: Instructions for how the PubChemQC3M dataset was generated from the entire PubChemQC database.
DOI: 10.60893/figshare.apr.26053378.v1
title: Clean SI

description: Clean SI
DOI: 10.6084/m9.figshare.4479434.v2
title: Problematic social media use: Results from a large-scale nationally representative adolescent sample

description: This is the data base for the paper called 'Problematic social media use: Results from a large-scale nationally representative adolescent sample' submitted in PlosONE.<br>
DOI: 10.6084/m9.figshare.3978894.v2
title: Development of a combined radiation and full thickness burn injury minipig model to study the effects of uncultured adipose-derived regenerative cell therapy in wound healing

description: <b>Purpose:</b> To develop an approach that models the cutaneous healing that occurs in a patient with full thickness thermal burn injury complicated by total body radiation exposure sufficient to induce sub-lethal prodromal symptoms. An assessment of the effects of an autologous cell therapy on wound healing on thermal burn injury with concomitant radiation exposure was used to validate the utility of the model. <b>Methods:</b> Göttingen minipigs were subjected to a 1.2 Gy total body irradiation by exposure to a 6 MV X-ray linear accelerator followed by ∼10 cm<sup>2</sup> full thickness burns (pre-heated brass block with calibrated spring). Three days after injury, wounds were excised to the underlying fascia and each animal was randomized to receive treatment with autologous adipose-derived regenerative cells (ADRC) delivered by local or intravenous injection, or vehicle control. Blood counts were used to assess radiation-induced marrow suppression. All animals were followed using digital imaging to assess wound healing. Full-thickness biopsies were obtained at 7, 14, 21 and 30 days’ post-treatment. <b>Results:</b> Compared to animals receiving burn injury alone, significant transient neutropenia and thrombocytopenia were observed in irradiated subjects with average neutrophil nadir of 0.79 × 10<sup>3</sup>/μl (day 15) and platelet nadir of 60 × 10<sup>3</sup>/μl (day 12). Wound closure through a combination of contraction and epithelialization from the wound edges occurred over a period of approximately 28 days’ post excision and treatment. Re-epithelialization was accelerated in wounds treated with ADRC (mean 3.5-fold increase at 2 weeks post-treatment relative to control). This acceleration was accompanied by an average 67% increase in blood vessel density and 30% increase in matrix (collagen) deposition. Similar results were observed when ADRC were injected either directly into the wound or by intravenous administration. <b>Conclusions:</b> Although preliminary, this study provides a reproducible minipig model of thermal burn injury complicated by myelosuppressive total body irradiation that utilizes standardized procedures to evaluate novel countermeasures for potential use following attack by an improvised nuclear device.
DOI: 10.6084/m9.figshare.5126272.v1
title: Supplementary Material for: Expression Patterns of Neuroligin-3 and Tyrosine Hydroxylase across the Brain in Mate Choice Contexts in Female Swordtails

description: Choosing mates is a commonly shared behavior across many organisms, with important fitness consequences. Variations in female preferences can be due in part to differences in neural and cellular activity during mate selection. Initial studies have begun to identify putative brain regions involved in mate preference, yet the understanding of the neural processes regulating these behaviors is still nascent. In this study, we characterized the expression of a gene involved in synaptogenesis and plasticity <i>(neuroligin-3)</i> and one that codes for the rate-limiting enzyme in dopamine biosynthesis (<i>tyrosine hydroxylase</i>; TH1) in the female <i>Xiphophorus nigrensis </i>(northern swordtail) brain as related to mate preference behavior. We exposed females to a range of different mate choice contexts including two large courting males (LL), two small coercive males (SS), and a context that paired a large courting male with a small coercive male (LS). <i>Neuroligin-3</i> expression in a mate preference context (LS) showed significant correlations with female preference in two telencephalic areas (Dm and Dl), a hypothalamic nucleus (HV), and two regions associated with sexual and social behavior (POA and Vv). We did not observe any context- or behavior-specific changes in <i>tyrosine hydroxylase</i> mRNA expression concomitant with female preference in any of the brain regions examined. Analysis of TH and <i>neuroligin-3</i> expression across different brain regions showed that expression patterns varied with the male social environment only for <i>neuroligin-3</i>, where the density of correlated expression between brain regions was positively associated with mate choice contexts that involved a greater number of courting male phenotypes (LS and LL). This study identified regions showing presumed high levels of synaptic plasticity using <i>neuroligin-3</i>, implicating and supporting their roles in female mate preference, but we did not detect any relationship between <i>tyrosine hydroxylase</i> and mate preference with 30 min of stimulus presentation in <i>X. nigrensis</i>. These data suggest that information about potential mates is processed in select forebrain regions and the entire brain shows different degrees of correlated expression depending on the mate preference context.
DOI: 10.6084/m9.figshare.13932119.v1
title: Gene database of genes on different human chromosomes

description: Since the advent of the genomics age that began in the 1990s with the sequencing of a couple of model bacterial and eukaryotic genomes, humans have been on a quest to sequence many species in our ecosystems to find commonalities and differences in sequence that help explain phenotypes. This led to the field of functional genomics, and which is what gave us the capability to automatically annotate a genome with sequence homology as probe. This work sought to provide the gene database of all genes in the human genome on a granular level by categorizing the genetic repertoire of humans at the chromosomal level. Specifically, an in-house MATLAB genome analysis software was used to parse the annotated genome sequence file of different chromosomes of the human genome. Variables that have been output for each gene includes gene name, gene function, promoter sequence and gene sequence. Such information, when aggregated at the level of chromosomes, and entire genome, should inform further studies seeking to unravel the mysteries that link gene sequence, gene expression, cell differentiation, and organismal developmental trajectories and phenotypes.
DOI: 10.6084/m9.figshare.23807859.v1
title: c1.ntw vConTACT files/virome network

description: Viral clustering filesThe data is shown in:<br>Rahlff J, et al. Heads in the clouds: marine viruses disperse bidirectionally along the natural water cycle. bioRxiv,(2022) doi: https://doi.org/10.1101/2022.06.21.497027<br>andRahlff J., Esser S.P., Plewka J., Heinrichs M.E., Soares A., Scarchilli C., Grigioni P., Wex H., Giebel H.A., & Probst A.J. (2023). Marine viruses disperse bidirectionally along the natural water cycle. <i>Nature Communications,</i> 14, 6354, doi: 10.1038/s41467-023-42125-5
DOI: 10.6084/m9.figshare.13978382.v1
title: Example-2021-02-13

description: This is an example.
DOI: 10.6084/m9.figshare.8798090.v1
title: MP NxTrim

description: MP NxTrim
DOI: 10.6084/m9.figshare.1262234.v1
title: TRANSGENERATIONAL STATE RIGHTS AND INTERNATIONAL LAW: SOCIAL BALANCE

description: This article aims to analyze the transgenerational rights of the State and its relationship with international law through a social balance. Therefore, it was initially a study of globalization, based on the work of François Chesnais. In a second step,<br>405<br>one addresses the rights and transgenerational risk society in Ulrich Beck. From this understanding, we analyze the goals of the Republic, in building a free, just and solidary, emphasizing corporate social responsibility as a way to achieve the development of the state.
DOI: 10.6084/m9.figshare.20024303.v1
title: GitHub Issues and Comments

description: Dataset containing GitHub issues (that are labeled using technical debt keywords) together with their comments. Both issues and comments have their GitHub reactions. The dataset is a MongoDB exported JSON.
DOI: 10.6084/m9.figshare.26541103.v1
title: Raw data Van der Hoeven et al 2024

description: Protein phosphatase PP1 has two active-site metals (Zn2+/Fe2+) that are essential for catalysis. However, when expressed in bacteria PP1 has 2 Mn2+-ions in its active site, indicating that the incorporation of Zn2+/Fe2+ depends on additional eukaryotic component(s). Here, we used purified, metal-deficient PP1 to study metal incorporation. Fe2+ was incorporated spontaneously, but Zn2+ was not. Mn2+-incorporation at physiological pH depended on the co-expression of PP1 with PPP1R2 (Inhibitor-2) or PPP1R11 (Inhibitor-3), or a pre-incubation of PP1 at pH 4. We also demonstrate that PPP1R2 and PPP1R11 are Zn2+-binding proteins but are, by themselves, not able to load PP1 with Zn2+. Our data suggest that PPP1R2 and PPP1R11 function as metal chaperones for PP1 but depend on co-chaperone(s) and/or specific modification(s) for the transfer of associated Zn2+ to PP1.
DOI: 10.6084/m9.figshare.17040404.v1
title: Supplementary Material for: Association of Attention-Deficit/Hyperactivity Disorder and Depression Polygenic Scores with Lithium Response: A Consortium for Lithium Genetics Study

description: Response to lithium varies widely between individuals with bipolar disorder (BD). Polygenic risk scores (PRSs) can uncover pharmacogenomics effects and may help predict drug response. Patients (<i>N</i> = 2,510) with BD were assessed for long-term lithium response in the Consortium on Lithium Genetics using the Retrospective Criteria of Long-Term Treatment Response in Research Subjects with Bipolar Disorder score. PRSs for attention-deficit/hyperactivity disorder (ADHD), major depressive disorder (MDD), and schizophrenia (SCZ) were computed using <i>lassosum</i> and in a model including all three PRSs and other covariates, and the PRS of ADHD (β = −0.14; 95% confidence interval [CI]: −0.24 to −0.03; <i>p</i> value = 0.010) and MDD (β = −0.16; 95% CI: −0.27 to −0.04; <i>p</i> value = 0.005) predicted worse quantitative lithium response. A higher SCZ PRS was associated with higher rates of medication nonadherence (OR = 1.61; 95% CI: 1.34–1.93; <i>p</i> value = 2e−7). This study indicates that genetic risk for ADHD and depression may influence lithium treatment response. Interestingly, a higher SCZ PRS was associated with poor adherence, which can negatively impact treatment response. Incorporating genetic risk of ADHD, depression, and SCZ in combination with clinical risk may lead to better clinical care for patients with BD.
DOI: 10.6084/m9.figshare.25388419.v1
title: data.dta

description: 2000-2019 Chinese patent and citation data from USPTO, by year by province
DOI: 10.15468/dl.wdgydd
title: Occurrence Download

description: A dataset listing the 3 species recorded in GBIF matching the query:
{
 "and" : [
 "Country is Australia",
 "DatasetKey is NSW BioNet Atlas",
 "Geometry POLYGON((151.59493 -33.18142,151.59077 -33.18275,151.59121 -33.1843,151.59125 -33.18934,151.59332 -33.19371,151.59742 -33.19412,151.60024 -33.19529,151.60525 -33.19503,151.60904 -33.19229,151.61017 -33.18832,151.60945 -33.18444,151.60738 -33.18193,151.60579 -33.17902,151.60253 -33.17835,151.59924 -33.17912,151.59493 -33.18142))",
 "IucnRedListCategory is one of (EX, EW, CR, EN, VU)",
 "OccurrenceStatus is Present"
 ]
}

 The dataset's 3 records were derived from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0009493-250426092105405/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.6084/m9.figshare.12950288.v1
title: Datasets and model for "Machine Learning for Impurity Charge-State Transition Levels in Semiconductors from Elemental Properties using Multi-Fidelity datasets"

description: Datasets and model for paper:<br>Machine Learning for Impurity Charge-State Transition Levels in Semiconductors from Elemental Properties using Multi-Fidelity datasets<br><br>by Maciej P. Polak, Ryan Jacobs, Arun Mannodi-Kanakkithodi, Maria K. Y. Chan and Dane Morgan<br>Published in: <br>J. Chem. Phys. (2022)<br>https://doi.org/10.1063/5.0083877<br>
DOI: 10.6084/m9.figshare.9710585.v1
title: Table 1. Gene Ontology (GO) analysis of proteins showing a consistent reduction in expression with FLG knockdown.

description: <b>Gene Ontology (GO) analysis of proteins showing a consistent reduction in expression with <i>FLG </i>knockdown.</b> The 10 most significant GO analysis terms in each of the GO domains are listed.
DOI: 10.6084/m9.figshare.28519973.v2
title: RAW Data and Figures for "Reinforcement of Conformity to the Majority or Minority: Effects of Task Ambiguity and the Salience of Reinforcing Stimuli"

description: This dataset contains both the RAW materials, the Tables and Figures supporting the findinfs of "Reinforcement of Conformity to the Majority or Minority: Effects of Task Ambiguity and the Salience of Reinforcing Stimuli"<br><br><br><br>
DOI: 10.6084/m9.figshare.12577727.v1
title: JVASP-60612 to JVASP-63554

description: JARVIS-DFT input/output files
DOI: 10.6084/m9.figshare.5125789.v1
title: Supplementary Material for: Age Dependency of Successful Recanalization in Anterior Circulation Stroke: The ENDOSTROKE Study

description: <b><i>Background:</i></b> Clinical outcome after endovascular stroke therapy (EVT) for proximal anterior circulation stroke is often disappointing despite high recanalization rates. The ENDOSTROKE study aims to determine predictors of clinical outcome in patients undergoing EVT. Here we focus on the impact of age and recanalization on proximal middle cerebral artery (M1-MCA) or carotid T occlusion. <b><i>Methods:</i></b> ENDOSTROKE is an investigator-initiated, industrially independent multicenter registry launched in January, 2011, for consecutive patients undergoing EVT for large-vessel stroke. This analysis focuses on patients treated in 11 academic and nonacademic stroke centers with angiographically proven M1-MCA (n = 259) or carotid T occlusion (n = 103). Recanalization was defined as Thrombolysis in Myocardial Infarction (TIMI) score 2 or 3, and in patients with available Thrombolysis in Cerebral Ischemia (TICI) data (n = 309) as TICI scores 2b-3. Good outcome was defined as modified Rankin Scale (mRS) score of 0-2 assessed after 3 months or later. <b><i>Results:</i></b> The median age was 68 years (25th and 75th percentiles: 56, 76 years), and the median National Institutes of Health Stroke Scale (NIHSS) score at admission was 16 (13, 19); 41% of the patients had a favorable (mRS scores 0-2), and 59% had an unfavorable (mRS scores 3-6) outcome; 83% reached TIMI 2-3 flow. Independent predictors of good outcome were younger age, lower initial NIHSS scores, TIMI 2/3 recanalization and lower serum glucose levels. Outcome was highly dependent on patients' age: 60% of the patients within the lowest age quartile (range: 18-56 years) experienced good clinical outcome, decreasing stepwise over 47% (57-68 years) and 37% (69-76 years) to 17% in the highest age quartile (77-94 years). The proportion of patients with poor clinical outcome despite TIMI 2/3 recanalization (‘futile recanalization') increased dramatically from only 29% in the lowest age quartile over 34% and 40% (2nd and 3rd age quartiles) up to 53% in the highest age quartile. Results were similar in patients with available TICI scores, with ‘futile recanalization' rates increasing from 24% to 46% (lowest to highest age quartile). <b><i>Conclusions:</i></b> This study emphasizes the dramatic impact of patients' age on outcome in EVT for M1-MCA or carotid T occlusion, even in the presence of recanalization. Reasons for this age-related decrease in clinically successful recanalization rates urgently need clarification and may comprise patient-related factors (age-related increase in cardioembolic strokes, collateral status, comorbidities) as well as periprocedural issues (tortuous vessel anatomy in the elderly, age-dependent negative impact of general anesthesia in EVT).
DOI: 10.6084/m9.figshare.5555395.v1
title: Wild-type6 3D

description: 3D microCT reconstruction of mouse tibiae-wild-type6
DOI: 10.6084/m9.figshare.1404233.v1
title: Cross cultural data for multivariate analysis of subsistence strategies

description: These are datasets of human subsistence, mobility, demographic, and environmental variables for the 186 cultures of the Standard Cross Cultural Sample. Missing values have been filled by Multiple Imputation methods in the R statistical package. These data are used in an analysis about human subsistence transitions that is submitted to PNAS. The R script used to complete those analyses is also included.
DOI: 10.6084/m9.figshare.14651262.v3
title: Datasets for the manuscript "Transitions of dissolution patterns in rough fractures" by Wang et al.

description: Datasets for the manuscript "Transitions of dissolution patterns in rough fractures" by Wang et al, including raw images recorded by camera, initial aperture distribution and other data shown in Figures in the main text.
DOI: 10.6084/m9.figshare.5401894.v4
title: Marry Who You Love: Intergroup Contact with Gay People and Another Stigmatized Group Is Related to Voting on Gay Rights through Perception of Threat

description: This dataset and syntax were used for a study that examined factors associated with discrimination against gay people in a public referendum aimed at the restriction of gay rights.
DOI: 10.6084/m9.figshare.7890641.v1
title: gVCF_NA18745

description: 1000 Genomes gVCF mapped to hs37d5 for NA18745. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.11993526.v1
title: Supplementary Material for: Tea Consumption Is Associated with Decreased Disease Activity of Rheumatoid Arthritis in a Real-World, Large-Scale Study

description: <b><i>Introduction:</i></b> The role of tea consumption on rheumatoid arthritis (RA) has been studied in recent years, but no clear conclusion has been drawn as a result of small sample size of the studies or the fact that only in vitro studies have been performed. <b><i>Objectives:</i></b> The aim of this study was to explore the possible association of tea consumption with RA through a large-scale, real-world study. <b><i>Methods:</i></b> A total of 733 RA patients were investigated from June to December, 2016. The disease activity of RA was assessed according to disease activity score 28-erythrocyte sedimentation rate. The amount and types of tea consumption were recorded by on-site self-administered questionnaires. Logistic regression models were applied to analyze the correlation between tea consumption and disease activity, adjusting for demographics, clinical and laboratory factors. <b><i>Results:</i></b> There was an inverse association between tea consumption and disease activity in RA patients (OR 0.66, 95% CI 0.46–0.94). Compared with non-tea drinkers, a higher-intake of tea (&gt;750 mL/day) was associated with lower disease activity of RA (OR 0.39, 95% CI 0.19–0.79), but not low-intake (≤750 mL/day; OR 0.83, 95% CI 0.42–1.63). A significant dose-response association was found between the amount of tea consumption and disease activity (<i>p</i> for trend &lt;0.01). Further hierarchical regression analysis showed that such inverse associations were mainly present in female patients (<i>p</i> = 0.004), non-smokers (<i>p</i> = 0.01) or elders (≥60 years; <i>p</i> = 0.01). <b><i>Conclusion:</i></b> Tea consumption is associated with decreased disease activity of RA, suggesting the potential beneficial effect of tea in the disease.