cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.12056709
title: Decreased Collagen Type I is Associated with Increased Metalloproteinase-2 Activity and Protein Expression of Leptin in the Myocardium of Obese Rats

description: Abstract Background Obesity is a risk factor for medical complications, including the cardiovascular system. There is limited information on collagen in the heart in obesity. Our previous study showed decreased protein levels of myocardial collagen type I in obese rats fed a high-fat diet for 34 weeks. However, the mechanisms responsible for low levels are not fully elucidated. Objective The purpose of this study was to test the hypothesis that the reduction in collagen type I is associated with increased metalloproteinase-2 (MMP-2) activity, which is linked to elevated leptin in the myocardium of obese rats. Methods Thirty-day-old male Wistar rats were randomized into two groups, control (standard diet) and obese (high-fat diet), and fed for 34 weeks. The general animal characteristics and metabolic and endocrine profiles were evaluated. Myocardial protein expressions of collagen I, leptin, tissue inhibitors of metalloproteinases (TIMP), and MMP-2 activity were assessed. Pearson correlation was employed to determine the associations between variables. The level of significance was 5%. Results The obese animals had increased adiposity index compared to control. Comorbidities such as glucose intolerance, hyperinsulinemia, insulin resistance, hyperleptinemia, and hypertension were observed in obese rats. Obesity reduced collagen I, TIMP-1, and TIMP-2, and it increased leptin and MMP-2 in the myocardium. There was a negative correlation between collagen I and MMP-2 and a positive correlation between leptin and MMP-2. Conclusion The hypothesis was confirmed; the reduction in collagen type I is associated with increased MMP-2 activity and leptin expression in the myocardium of obese rats. (Arq Bras Cardiol. 2020; [online].ahead print, PP.0-0)
DOI: 10.6084/m9.figshare.12056715
title: Mineral contents in the skin and flesh of fruits of apple cultivars

description: Abstract Apple is considered a functional food, since it presents considerable contribution in the supply of antioxidants, vitamins and minerals, and its consumption is related to the prevention of various diseases. However, most cultivars released in recent years have been poorly studied regarding their nutritional properties. The aim of this work was to quantify mineral contents in the skin and flesh, of apple cultivars with potential production in southern Brazil. The apple cultivars evaluated were ‘Fuji Suprema’, ‘Castel Gala’, ‘Lisgala’, ‘Monalisa’, ‘Luiza’, ‘Daiane’, ‘Venice’, ‘Elenise’ and M.10-09 advanced selection, in the 2017/2018 and 2018/2019 seasons. Among evaluated minerals, considering consumption of a fruit of 115 g with skin (except carpel and seeds), potassium supplies high percentage of recommended daily intake, followed by phosphorus and magnesium. The calcium content in apples presents low contribution to the recommended daily intake. Due to the higher concentrations of minerals in skin in comparison to flesh, the consumption of whole fruit increases the percentage of minerals ingested. In addition, the evaluated minerals showed significant differences as a function of cultivar. ‘Monalisa’ cultivar, in the flesh portion, stood out due to the high phosphorus and calcium content, 204.1 and 36.5 mg kg-1 (2017/2018) and 305.6 and 43.8 mg kg-1 (2018/2019), respectively. ‘Fuji Suprema’, in both harvest seasons, stood out due to the high potassium contents in skin (1073.8 mg kg-1) and flesh (1223.7 mg kg-1) in 2017/2018 and in flesh (1547.3 mg kg-1) in 2018/2019 and magnesium in flesh (122.4 mg kg-1) in 2017/2018 and in skin (231.2 mg kg-1) and flesh (62.4 mg kg-1) in 2018/2019.
DOI: 10.6084/m9.figshare.12056709.v1
title: Decreased Collagen Type I is Associated with Increased Metalloproteinase-2 Activity and Protein Expression of Leptin in the Myocardium of Obese Rats

description: Abstract Background Obesity is a risk factor for medical complications, including the cardiovascular system. There is limited information on collagen in the heart in obesity. Our previous study showed decreased protein levels of myocardial collagen type I in obese rats fed a high-fat diet for 34 weeks. However, the mechanisms responsible for low levels are not fully elucidated. Objective The purpose of this study was to test the hypothesis that the reduction in collagen type I is associated with increased metalloproteinase-2 (MMP-2) activity, which is linked to elevated leptin in the myocardium of obese rats. Methods Thirty-day-old male Wistar rats were randomized into two groups, control (standard diet) and obese (high-fat diet), and fed for 34 weeks. The general animal characteristics and metabolic and endocrine profiles were evaluated. Myocardial protein expressions of collagen I, leptin, tissue inhibitors of metalloproteinases (TIMP), and MMP-2 activity were assessed. Pearson correlation was employed to determine the associations between variables. The level of significance was 5%. Results The obese animals had increased adiposity index compared to control. Comorbidities such as glucose intolerance, hyperinsulinemia, insulin resistance, hyperleptinemia, and hypertension were observed in obese rats. Obesity reduced collagen I, TIMP-1, and TIMP-2, and it increased leptin and MMP-2 in the myocardium. There was a negative correlation between collagen I and MMP-2 and a positive correlation between leptin and MMP-2. Conclusion The hypothesis was confirmed; the reduction in collagen type I is associated with increased MMP-2 activity and leptin expression in the myocardium of obese rats. (Arq Bras Cardiol. 2020; [online].ahead print, PP.0-0)
DOI: 10.6084/m9.figshare.12056715.v1
title: Mineral contents in the skin and flesh of fruits of apple cultivars

description: Abstract Apple is considered a functional food, since it presents considerable contribution in the supply of antioxidants, vitamins and minerals, and its consumption is related to the prevention of various diseases. However, most cultivars released in recent years have been poorly studied regarding their nutritional properties. The aim of this work was to quantify mineral contents in the skin and flesh, of apple cultivars with potential production in southern Brazil. The apple cultivars evaluated were ‘Fuji Suprema’, ‘Castel Gala’, ‘Lisgala’, ‘Monalisa’, ‘Luiza’, ‘Daiane’, ‘Venice’, ‘Elenise’ and M.10-09 advanced selection, in the 2017/2018 and 2018/2019 seasons. Among evaluated minerals, considering consumption of a fruit of 115 g with skin (except carpel and seeds), potassium supplies high percentage of recommended daily intake, followed by phosphorus and magnesium. The calcium content in apples presents low contribution to the recommended daily intake. Due to the higher concentrations of minerals in skin in comparison to flesh, the consumption of whole fruit increases the percentage of minerals ingested. In addition, the evaluated minerals showed significant differences as a function of cultivar. ‘Monalisa’ cultivar, in the flesh portion, stood out due to the high phosphorus and calcium content, 204.1 and 36.5 mg kg-1 (2017/2018) and 305.6 and 43.8 mg kg-1 (2018/2019), respectively. ‘Fuji Suprema’, in both harvest seasons, stood out due to the high potassium contents in skin (1073.8 mg kg-1) and flesh (1223.7 mg kg-1) in 2017/2018 and in flesh (1547.3 mg kg-1) in 2018/2019 and magnesium in flesh (122.4 mg kg-1) in 2017/2018 and in skin (231.2 mg kg-1) and flesh (62.4 mg kg-1) in 2018/2019.
DOI: 10.6084/m9.figshare.12056718.v1
title: Cognitive impairment in chronic migraine: a cross-sectional study in a clinic-based sample

description: Abstract Cognitive impairment has been described in all phases of a migraine attack and interictally. However, the prevalence and phenotype of such impairment in chronic migraine (CM) have not yet been studied. Objectives: The aim of this study was to evaluate both the prevalence of the objective cognitive deficit in patients with CM and the factors underlying its etiology. Methods: 144 patients with CM and 44 age-matched patients with low-frequency episodic migraine (EM) (a maximum of 4 headache days per month) participated in this study. Neuropsychiatric characteristics were measured with the HADS Hospital Anxiety and Depression Scale. Cognitive function was assessed with the Montreal Cognitive Assessment (MoCA), Digit Symbol Substitution Test (DSST), Rey Auditory Verbal Learning Test (RAVLT), and the Perceived Deficits Questionnaire (PDQ-20). Results: Compared to EM, CM subjects demonstrated higher subjective and objective cognitive impairment across all tests. CM patients had 4 times higher odds of achieving a RAVLT score in the lower quartile range compared to EM (Odds Ratio [OR] 3.8; 95% confidence interval [95%CI] 1.5‒9.6; р=0.005). In the MoCA, CM patients demonstrated the most striking impairment in memory/delayed recall (65.3%), attention (46.5%), abstraction (30.6%), and language (27.1%). Chronic headache and level of education, but not gender, depression or anxiety, were independent predictors of cognitive impairment. Conclusions: Cognitive impairment is prevalent in the CM population during their mildest possible pain and may be caused by a central sensitization. Timely preventive treatment of EM is warranted.
DOI: 10.6084/m9.figshare.12056703
title: Clinical Characteristics of Resistant vs. Refractory Hypertension in a Population of Hypertensive Afrodescendants

description: Abstract Background Afrodescendants have been associated with a greater severity of arterial hypertension and a higher incidence of cardiovascular complications. Characteristics in the presentation of resistant hypertension (RH) or refractory hypertension (RfH), specifically in this ethnic group, have not been properly studied. Objectives The study compares clinical and epidemiological characteristics and prevalence of cardiovascular events in people of African descent diagnosed with RH or RfH. Methods Cross-sectional study carried out in a referral clinic for patients with severe hypertension. The level of significance was 5%. Results 146 consecutive patients were evaluated, of which 68.7% were female. The average age was 61.8 years, with 88.4% of Afrodescendants (mixed race or black). 51% had RfH. There was a high prevalence of cardiovascular risk factors: 34.2% of subjects had diabetes, 69.4% dyslipidemia, 36.1% obesity, and 38.3% history of smoking. Reduced renal function was seen in 34.2%. Previous cardiovascular events occurred in 21.8% for myocardial infarction and in 19.9% for stroke. The Framingham’s risk score was moderate/high at 61%. RfH patients were younger (mean age 59.38±11.69 years versus 64.10±12.23 years, p=0.02), had more dyslipidemia (83.8 versus 66.7%, p=0.021), and stroke (30.4 versus 12.3%, p=0.011) when compared to those with RH. The use of a combination of ACEi/ARB+CCB+Diuretic, chlortalidone and spironolactone was also more frequent in individuals with RfH. Conclusion Africandescendant people with RH had a high cardiovascular risk, a high prevalence of RfH, a higher frequency of dyslipidemia and stroke, compatible with a high incidence of injury to target organs. (Arq Bras Cardiol. 2020; [online].ahead print, PP.0-0)
DOI: 10.6084/m9.figshare.12056697
title: Risk of Atrial Fibrillation after Ablation of Cavotricuspid Isthmus-Dependent Atrial Flutter: Is Combined Ablation of Atrial Fibrillation Worthwhile?

description: Abstract Background Simultaneous ablation of atrial fibrillation (AF) and cavotricuspid isthmus (CTI)-dependent atrial flutter can be performed when both arrythmias had been recorded before the procedure. However, the best approach has not been defined in case of patients referred for ablation with CTI-dependent atrial flutter, without history of AF. Objectives To assess the prevalence and to identify predictors of the first episode of AF after ablation of CTI-dependent atrial flutter in patients without history of AF. Methods Retrospective cohort of patients with CTI-dependent atrial flutter without history of AF undergoing catheter ablation. Clinical characteristics were compared between patients who developed AF and those who did not have AF after the procedure. Significance level was set at 5%. In the analysis of predicting factors, the primary outcome was occurrence of AF after CTI-dependent atrial flutter ablation. Results Of a total of 227 patients undergoing ablation of CTI-dependent atrial flutter (110 with history of AF and 33 without adequate follow-up), 84 were included, and 45 (53.6%) developed post-ablation AF. The HATCH and CHA2DS2-VASC scores were not different between the groups. Recurrence rate of CTI-dependent atrial flutter and complication rate were 11.5% and 1.2%, respectively, after ablation. Conclusions Although ablation of CTI-dependent atrial flutter is a safe and effective procedure, 50% of the patients developed AF after the procedure. However, the role of combined ablation (CTI-dependent atrial flutter plus AF) aiming at preventing AF is still uncertain. (Arq Bras Cardiol. 2020; [online].ahead print, PP.0-0)
DOI: 10.6084/m9.figshare.12056691
title: Effect of pelvimetric diameters on success of surgery in patients submitted to robot-assisted perineal radical prostatectomy

description: ABSTRACT Objective: Minimally invasive techniques are used increasingly by virtue of advancements in technology. Surgery for prostate cancer, which has high morbidity, is performed with an increasing momentum based on the successful oncological and functional outcomes as well as cosmetic aspects. Materials and methods: Sixty two patients underwent robot-assisted perineal radical prostatectomy (R-PRP) surgery at our clinic between November 2016 and August 2017. Six pelvimetric dimensions were defined and measured by performing multiparametric magnetic resonance imaging (mpMRI) prior to operation in all patients. In light of these data, we aimed to investigate the effect of pelvimetric measurements on surgery duration and surgical margin positivity. Results: By using this technique in pelvic area, we observed that measurements only representing surgical site and excluding other pelvic organs had a significant effect on surgery duration, and pelvic dimensions had no significant effect on surgical margin positivity. Conclusion: In R-PRP technique, peroperative findings and oncological outcomes can vary depending on several variable factors, but although usually not taken into account, pelvimetric measurements can also affect these outcomes. However, there is a need for randomised controlled trials to be conducted with more patients.
DOI: 10.6084/m9.figshare.12056703.v1
title: Clinical Characteristics of Resistant vs. Refractory Hypertension in a Population of Hypertensive Afrodescendants

description: Abstract Background Afrodescendants have been associated with a greater severity of arterial hypertension and a higher incidence of cardiovascular complications. Characteristics in the presentation of resistant hypertension (RH) or refractory hypertension (RfH), specifically in this ethnic group, have not been properly studied. Objectives The study compares clinical and epidemiological characteristics and prevalence of cardiovascular events in people of African descent diagnosed with RH or RfH. Methods Cross-sectional study carried out in a referral clinic for patients with severe hypertension. The level of significance was 5%. Results 146 consecutive patients were evaluated, of which 68.7% were female. The average age was 61.8 years, with 88.4% of Afrodescendants (mixed race or black). 51% had RfH. There was a high prevalence of cardiovascular risk factors: 34.2% of subjects had diabetes, 69.4% dyslipidemia, 36.1% obesity, and 38.3% history of smoking. Reduced renal function was seen in 34.2%. Previous cardiovascular events occurred in 21.8% for myocardial infarction and in 19.9% for stroke. The Framingham’s risk score was moderate/high at 61%. RfH patients were younger (mean age 59.38±11.69 years versus 64.10±12.23 years, p=0.02), had more dyslipidemia (83.8 versus 66.7%, p=0.021), and stroke (30.4 versus 12.3%, p=0.011) when compared to those with RH. The use of a combination of ACEi/ARB+CCB+Diuretic, chlortalidone and spironolactone was also more frequent in individuals with RfH. Conclusion Africandescendant people with RH had a high cardiovascular risk, a high prevalence of RfH, a higher frequency of dyslipidemia and stroke, compatible with a high incidence of injury to target organs. (Arq Bras Cardiol. 2020; [online].ahead print, PP.0-0)
DOI: 10.6084/m9.figshare.12056697.v1
title: Risk of Atrial Fibrillation after Ablation of Cavotricuspid Isthmus-Dependent Atrial Flutter: Is Combined Ablation of Atrial Fibrillation Worthwhile?

description: Abstract Background Simultaneous ablation of atrial fibrillation (AF) and cavotricuspid isthmus (CTI)-dependent atrial flutter can be performed when both arrythmias had been recorded before the procedure. However, the best approach has not been defined in case of patients referred for ablation with CTI-dependent atrial flutter, without history of AF. Objectives To assess the prevalence and to identify predictors of the first episode of AF after ablation of CTI-dependent atrial flutter in patients without history of AF. Methods Retrospective cohort of patients with CTI-dependent atrial flutter without history of AF undergoing catheter ablation. Clinical characteristics were compared between patients who developed AF and those who did not have AF after the procedure. Significance level was set at 5%. In the analysis of predicting factors, the primary outcome was occurrence of AF after CTI-dependent atrial flutter ablation. Results Of a total of 227 patients undergoing ablation of CTI-dependent atrial flutter (110 with history of AF and 33 without adequate follow-up), 84 were included, and 45 (53.6%) developed post-ablation AF. The HATCH and CHA2DS2-VASC scores were not different between the groups. Recurrence rate of CTI-dependent atrial flutter and complication rate were 11.5% and 1.2%, respectively, after ablation. Conclusions Although ablation of CTI-dependent atrial flutter is a safe and effective procedure, 50% of the patients developed AF after the procedure. However, the role of combined ablation (CTI-dependent atrial flutter plus AF) aiming at preventing AF is still uncertain. (Arq Bras Cardiol. 2020; [online].ahead print, PP.0-0)
DOI: 10.6084/m9.figshare.12056688
title: THE LEGACY OF ELINOR OSTROM ON COMMON FORESTS RESEARCH ASSESSED THROUGH BIBLIOMETRIC ANALYSIS

description: ABSTRACT A bibliometric analysis was performed to evaluate the research on common forest management that were influenced by the seminal work of Elinor Ostrom (Governing the Commons), from 1990 to 2018. This analysis was based on the online database of the Science Citation Index Expanded - Web of Science©. Six main aspects of the retrieved publications were evaluated: (1) publication years; (2) journals; (3) countries (or regions); (4) study approach type; (5) authors; and (6) keywords. This research topic has shown to be relevant all over the world. Authors from 34 different countries have been conducting studies based on Ostrom’s theory. Researchers have addressed this research topic primarily through case studies (approximately 83% of the publications). Among the retrieved literature body, the USA, Ecuador, Slovenia, Tanzania and Bangladesh have presented more than two case studies. All retrieved publications were published in 16 different journals. “Forest Policy and Economics” and “Ecology & Society” were the two most widely used journals to disseminate results. Around 115 different author’s expressions have been used as keywords to describe this subject. The main concepts addressed by the authors were: “Forest Governance”; “Institutional Analysis and Development Framework”; “Property Rights”; “Socio-ecological Systems”; “Community-based Forest Management”; “Co-management”; “Design Principles”; “Institutions”; “Common-pool Resource” and; “Sustainability”. Overall, this framework proved to be effective to evaluate the research trends, conflicting results and knowledge gaps surrounding the theme, and to contribute with researchers and governments on management and decision-making on this domain.
DOI: 10.6084/m9.figshare.12056682
title: Bioethical discussion on end of life patient care

description: Abstract This study aimed at identifying factors that influence the decision-making of health professionals regarding patients in intensive care units. We carried out a quantitative research in two hospitals in Paraná, between March and May 2018. We defined a sample of 45 members of a multidisciplinary team. As results, we identified the interviewees’ concern in respecting autonomy, protecting dignity and preserving the quality of life of patients and family members by making shared decision. However, we also observed a tendency of therapeutic obstinacy to fulfill the professional duty, which indicated the need for more discussions and training on palliative care to minimize ethical conflicts. Approval CEP-PUCPR 2.397.069/2017
DOI: 10.6084/m9.figshare.12056688.v1
title: THE LEGACY OF ELINOR OSTROM ON COMMON FORESTS RESEARCH ASSESSED THROUGH BIBLIOMETRIC ANALYSIS

description: ABSTRACT A bibliometric analysis was performed to evaluate the research on common forest management that were influenced by the seminal work of Elinor Ostrom (Governing the Commons), from 1990 to 2018. This analysis was based on the online database of the Science Citation Index Expanded - Web of Science©. Six main aspects of the retrieved publications were evaluated: (1) publication years; (2) journals; (3) countries (or regions); (4) study approach type; (5) authors; and (6) keywords. This research topic has shown to be relevant all over the world. Authors from 34 different countries have been conducting studies based on Ostrom’s theory. Researchers have addressed this research topic primarily through case studies (approximately 83% of the publications). Among the retrieved literature body, the USA, Ecuador, Slovenia, Tanzania and Bangladesh have presented more than two case studies. All retrieved publications were published in 16 different journals. “Forest Policy and Economics” and “Ecology & Society” were the two most widely used journals to disseminate results. Around 115 different author’s expressions have been used as keywords to describe this subject. The main concepts addressed by the authors were: “Forest Governance”; “Institutional Analysis and Development Framework”; “Property Rights”; “Socio-ecological Systems”; “Community-based Forest Management”; “Co-management”; “Design Principles”; “Institutions”; “Common-pool Resource” and; “Sustainability”. Overall, this framework proved to be effective to evaluate the research trends, conflicting results and knowledge gaps surrounding the theme, and to contribute with researchers and governments on management and decision-making on this domain.