cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.23578770.v1
title: Metallic W/WO2 solid-acid catalyst boosts hydrogen evolution reaction in alkaline electrolyte

description: The lack of available protons severely lowers the activity of alkaline hydrogen evolution reaction (HER) process than that in acids, which can be efficiently accelerated by tuning the coverage and chemical environment of protons on catalyst surface. However, the cycling of active sites by proton transfer is largely depended on the utilization of noble metal catalysts because of the appealing electronic interaction between noble metal atoms and protons. Herein, an all-non-noble W/WO2 metallic heterostructure serving as an efficient solid-acid catalyst exhibits remarkable HER performance with an ultra-low overpotential of -35 mV at -10 mA/cm2 and a small Tafel slope (-34 mV/dec), as well as long-term durability of hydrogen production (&gt;50 h) at current densities of -10 and -50 mA/cm2 in alkaline electrolyte. Multiple in situ and ex situ spectroscopy characterizations combining with first-principle density functional theory (DFT) calculations discover that a dynamic proton-concentrated surface can be constructed on W/WO2 solid-acid catalyst under ultra-low overpotentials, which enables W/WO2 catalyzing alkaline hydrogen production to follow a kinetically fast Volmer-Tafel pathway with two neighboring protons recombining into a hydrogen molecule. Our strategy of solid-acid catalyst and utilization of multiple spectroscopy characterizations may provide a new route for designing advanced all-non-noble catalytic system towards boosting HER performance in alkaline electrolyte.
DOI: 10.6084/m9.figshare.23578775
title: Design, synthesis, and evaluation of novel benzoylhydrazone derivatives as Nur77 modulators with potent antitumor activity against hepatocellular carcinoma

description: Nur77 modulators have emerged as a promising therapeutic approach for hepatocellular carcinoma. In this study, a structure-based rational drug design approach was used to design and synthesise a series of 4-((8-hydroxy-2-methylquinolin-4-yl)amino)benzoylhydrazone derivatives based on the binding characteristics of our previously reported <b>10g</b> and the native ligand <b>3NB</b> at the binding Site C of Nur77. Cell-based cytotoxicity assays revealed that compound <b>TMHA37</b> demonstrated the highest cytotoxicity against all tested cancer cells. The induced fit docking and binding pose metadynamics simulation suggested that <b>TMHA37</b> was the most promising Nur77 binder at Site C. Molecular dynamics simulation validated the stable binding of <b>TMHA37</b> to Nur77’s Site C but not to Sites A or B. Specifically, <b>TMHA37</b> bound strongly to Nur77-LBD (<i>K</i><sub>D</sub> = 445.3 nM) and could activate Nur77’s transcriptional activity. Furthermore, <b>TMHA37</b> exhibited antitumor effects by blocking the cell cycle at G2/M phase and inducing cell apoptosis in a Nur77-dependent manner.
DOI: 10.6084/m9.figshare.23578775.v1
title: Design, synthesis, and evaluation of novel benzoylhydrazone derivatives as Nur77 modulators with potent antitumor activity against hepatocellular carcinoma

description: Nur77 modulators have emerged as a promising therapeutic approach for hepatocellular carcinoma. In this study, a structure-based rational drug design approach was used to design and synthesise a series of 4-((8-hydroxy-2-methylquinolin-4-yl)amino)benzoylhydrazone derivatives based on the binding characteristics of our previously reported <b>10g</b> and the native ligand <b>3NB</b> at the binding Site C of Nur77. Cell-based cytotoxicity assays revealed that compound <b>TMHA37</b> demonstrated the highest cytotoxicity against all tested cancer cells. The induced fit docking and binding pose metadynamics simulation suggested that <b>TMHA37</b> was the most promising Nur77 binder at Site C. Molecular dynamics simulation validated the stable binding of <b>TMHA37</b> to Nur77’s Site C but not to Sites A or B. Specifically, <b>TMHA37</b> bound strongly to Nur77-LBD (<i>K</i><sub>D</sub> = 445.3 nM) and could activate Nur77’s transcriptional activity. Furthermore, <b>TMHA37</b> exhibited antitumor effects by blocking the cell cycle at G2/M phase and inducing cell apoptosis in a Nur77-dependent manner.
DOI: 10.15139/s3/xpyawv
title: Using safe systems approach to assess traffic impact and land development [R35]

description: Traffic impact analysis (TIA) is an important piece of how our transportation system is planned, designed, and built. Cities and states use TIAs to assess how road users currently use the transportation system and then predict how the system will operate if transportation patterns change through the addition of new buildings within an area or through new capacity added to the roadway. Many local and state governments view the TIA process as a critical means of generating needed infrastructure improvements, and its use has become ubiquitous among DOTs across the US. TIA can therefore exert a powerful influence on urban land use and transportation systems. However, little attention has been paid in research or in current practices to TIA’s direct impacts on road safety or its potential role in shaping safe systems. This is somewhat surprising, given TIA’s conventional deployment as a means to minimize and mitigate the traffic congestion impacts of new development by tying roadway capacity improvements to land development permits. This project addresses this gap by (1) evaluating whether, how, and the extent to which current TIA practices incorporate safety into assessments of impacts of land development or into strategies to mitigate those impacts, (2) identifying opportunities to integrate safe systems concepts and metrics into the development review process, and (3) advancing a new, safe systems-approach to estimating and minimizing the safety impacts of new land development.
DOI: 10.6084/m9.figshare.7850156.v1
title: Additional file 2: of Singleton molecular species delimitation based on COI-5P barcode sequences revealed high cryptic/undescribed diversity for Chinese katydids (Orthoptera: Tettigoniidae)

description: Table S2. The distance within-species and to its nearest neighbor (NN). (XLSX 21 kb)
DOI: 10.6073/pasta/4d4ab1d167c790ae0cb2ab71cfbcd65d
title: WARM experiment Soil Microbial Function, RMBL Colorado, 2021

description: We examined how abiotic (warming), and biotic (presence of dominant plant species) factors interact to affect soil microbial processes in montane meadow ecosystems at high and low elevations at the WaRM experimental sites near the Rocky Mountain Biological Laboratory in Colorado in the West Elk range of the southern Rocky Mountains in Colorado, USA, during the summer 2021 growing season. The low elevation site (low site) is at 2740 m elevation (38.715, -106.823) in an open meadow without tree cover, and the dominant plant species is a flowering forb, Wyethia amplexicaulis. The high elevation site (high site) (3460 m, 38.992, -107.067) is also described as open meadow with no tree cover and is dominated by Juncus drummondii, a monocot, grass-like herb. The low and high elevation sites have a mean summertime temperature of 14.9 and 10.9°C respectively, and a mean summertime precipitation of 143 and 151 mm
 The WaRM experimental design is a 2 × 2 factorial warming × dominant plant species removal experiment deployed at the high elevation site and the low elevation site. Each of the four treatments are replicated 8 times, for total of 32 plots (each of which is 2 × 2 m) at each elevation with warming imposed via transparent hexagonal open-top chambers (OTCs), 1.5 m in diameter, in the center of each warming plot and the dominant plant species (listed above) removed via clipping at soil level within removal plots. Treatments at this site have been deployed each summer (June-August) since 2013.
 We analyzed multiple soil microbial responses at three times throughout the growing season: pre-growing season [low site; approx. May 26, high site; approx. July 6], peak-growing season [low site; approx. June 23, high site; approx. July 21], and post-growing season [low site; approx. August 18, high site; approx. Sept 14]. We measured edaphic characteristics including volumetric soil water content. We measured soil microbial functions including soil respiration, microbial metabolic functional diversity, microbial biomass carbon and nitrogen, and extracellular enzyme potential activity.
DOI: 10.6084/m9.figshare.7850150
title: Additional file 1: of Singleton molecular species delimitation based on COI-5P barcode sequences revealed high cryptic/undescribed diversity for Chinese katydids (Orthoptera: Tettigoniidae)

description: Table S1. Additional 34 COI-5P sequences that were mined from GenBank. (XLSX 23 kb)
DOI: 10.6084/m9.figshare.7850150.v1
title: Additional file 1: of Singleton molecular species delimitation based on COI-5P barcode sequences revealed high cryptic/undescribed diversity for Chinese katydids (Orthoptera: Tettigoniidae)

description: Table S1. Additional 34 COI-5P sequences that were mined from GenBank. (XLSX 23 kb)
DOI: 10.6084/m9.figshare.7850156
title: Additional file 2: of Singleton molecular species delimitation based on COI-5P barcode sequences revealed high cryptic/undescribed diversity for Chinese katydids (Orthoptera: Tettigoniidae)

description: Table S2. The distance within-species and to its nearest neighbor (NN). (XLSX 21 kb)
DOI: 10.6084/m9.figshare.14140152
title: Additional file 4 of Blinatumomab-induced T cell activation at single cell transcriptome resolution

description: Additional file 4: Table S3. Differentially expressed genes induced by blinatumomab in cell line model.
DOI: 10.6084/m9.figshare.7850180.v1
title: Additional file 2: of Genome-wide profiling of RNA editing sites in sheep

description: Putative RDDs in Sheep Individual1. (XLSX 1098 kb)
DOI: 10.6084/m9.figshare.7850186
title: Additional file 3: of Genome-wide profiling of RNA editing sites in sheep

description: Putative RDDs in Sheep Individual2. (XLSX 880 kb)
DOI: 10.6084/m9.figshare.7850186.v1
title: Additional file 3: of Genome-wide profiling of RNA editing sites in sheep

description: Putative RDDs in Sheep Individual2. (XLSX 880 kb)
DOI: 10.6084/m9.figshare.7850192
title: Additional file 4: of Genome-wide profiling of RNA editing sites in sheep

description: Putative RDDs in Sheep Individual3. (XLSX 1115 kb)
DOI: 10.6084/m9.figshare.7850192.v1
title: Additional file 4: of Genome-wide profiling of RNA editing sites in sheep

description: Putative RDDs in Sheep Individual3. (XLSX 1115 kb)
DOI: 10.15139/s3/ibkhyv
title: An enhanced systemic approach to safety [R2]

description: To date, the dominant approach used by state agencies to allocate safety resources is the hotspot approach, which focuses on identifying and recommending improvements for high collision concentration locations. Another approach is the systemic approach that seeks blanket improvements that can be implemented at sites across the road network, based on specific roadway features that are associated with a particular crash type. While the hotspot approach is reactive in the sense that it focuses exclusively on sites that already had crashes, the systemic approach has both reactive and proactive components to it. The systemic approach is reactive since it uses historical crash data to identify the type of roadways that suffer from recurring safety concerns, and it is proactive in the sense that it provides a mechanism to make improvements at sites that share the same design and operational attributes, but have not had many (or any) crashes yet. The systemic approach is typically used in parallel to the hotspot approach and is considered a complement rather than an alternative. This study developed a prototype tool for conducting a systemic safety analysis for a scalable area. At the core is a transparent systemic crash matrix that shows what types of crashes occur on what types of facilities. The different rows in the systemic matrix represent different crash types, while the columns represent different facility types. The cells of the matrix are referred to as crash profiles and include the number of crashes that occurred for each crash profile. This method provides an agency with a simple-to-assemble, simple-to-interpret snapshot of any systemic problems on their network or study area. The prototype tool allows for conducting a systemic safety analysis that can be conducted simultaneously for all modes of traffic, along with a set of possible engineering and non-engineering countermeasures; and a systemic tool that can provide agencies with the ability to make systemic data-driven blanket improvements across a desired area to support system-wide safety improvement.
DOI: 10.6084/m9.figshare.7850180
title: Additional file 2: of Genome-wide profiling of RNA editing sites in sheep

description: Putative RDDs in Sheep Individual1. (XLSX 1098 kb)
DOI: 10.6084/m9.figshare.12043569
title: Additional file 8 of Transcriptomic and metabolomic analysis provides insights into anthocyanin and procyanidin accumulation in pear

description: Additional file 8:Table S8. Correlation analysis between 20 core genes and 10 anthocyanins and seven procyanidins.
DOI: 10.15139/s3/31genm
title: Advancing crash investigation with connected and automated vehicle data [R25]

description: This study seeks to leverage newly available Connected and Automated Vehicle (CAV) data to improve crash investigation procedures and obtain input from stakeholders, specifically law enforcement. In particular, law enforcement use of existing Event Data Recorders (EDRs), which store vehicle kinematics during a crash, is explored. Crash investigations are currently aided by EDRs, but this aid could be expanded to include the information gathered by Automated Driving System (ADS) technologies such as radar, cameras, LIDAR, infrared, and ultrasonic. This detailed data could improve the fidelity of future crash investigations, with potential new information such as driver/operator state, vehicle automation capabilities, location, objects and people in the immediate area, performance and diagnostic data, and environmental factors. Through text mining analysis of CAV and sensor-related literature and interviews with law enforcement, this study contributes by gathering evidence about crash investigations to pinpoint the contributing factors of a crash. Further we explore law enforcement involvement in the design of the current EDR retrieval process and their knowledge about using ADS data. Broadly, the project applies the safe systems approach by suggesting a framework that integrates CAV data in the new crash investigation procedures.
DOI: 10.48597/rs7x-8jm6
title: Measurement of Lead at Lahemaa

description: Measurement of Lead at Lahemaa
DOI: 10.48597/rw9p-km5w
title: Measurement of Magnesium at Lahemaa

description: Measurement of Magnesium at Lahemaa
DOI: 10.48597/se3y-5sy2
title: Measurement of Inden_123cd_pyrene at Rucava

description: Measurement of Inden_123cd_pyrene at Rucava
DOI: 10.48597/t3a4-342k
title: Measurement of Cadmium at Lahemaa

description: Measurement of Cadmium at Lahemaa
DOI: 10.48597/t95d-p9qn
title: Measurement of Precipitation_amount at Rucava

description: Measurement of Precipitation_amount at Rucava
DOI: 10.48597/tfnq-exd6
title: Measurement of Sulphate_total at Rucava

description: Measurement of Sulphate_total at Rucava
DOI: 10.48597/u4m2-4jag
title: Measurement of Magnesium at Rucava

description: Measurement of Magnesium at Rucava
DOI: 10.48597/ueqp-hajd
title: Measurement of Pm25_mass at Rucava

description: Measurement of Pm25_mass at Rucava
DOI: 10.48597/ujqg-b6xz
title: Measurement of Ammonium at Vilsandi

description: Measurement of Ammonium at Vilsandi
DOI: 10.48597/umdp-c89z
title: Measurement of Heavy metals at Alfragide

description: Measurement of Heavy metals at Alfragide
DOI: 10.48597/uqwu-yfzb
title: Measurement of Ozone at Lahemaa

description: Measurement of Ozone at Lahemaa
DOI: 10.48597/v3ac-vqtu
title: Measurement of POPs (persistent organic pollutants) at Monte Velho

description: Measurement of POPs (persistent organic pollutants) at Monte Velho
DOI: 10.48597/v4bb-ncwp
title: Measurement of Precipitation_amount at Vilsandi

description: Measurement of Precipitation_amount at Vilsandi
DOI: 10.48597/v76v-mhww
title: Measurement of Calcium at Vilsandi

description: Measurement of Calcium at Vilsandi
DOI: 10.48597/v7kg-47rh
title: Measurement of Sodium at Lahemaa

description: Measurement of Sodium at Lahemaa
DOI: 10.48597/v8kh-4vee
title: Measurement of Sulphate_total at Vilsandi

description: Measurement of Sulphate_total at Vilsandi
DOI: 10.48597/vcxp-a3pp
title: Measurement of Ozone at Zoseni

description: Measurement of Ozone at Zoseni
DOI: 10.48597/vqhx-3aws
title: Measurement of Ammonium at Rucava

description: Measurement of Ammonium at Rucava
DOI: 10.48597/vxfd-uq73
title: Measurement of Inorganics in air and particle phase at Tange

description: Measurement of Inorganics in air and particle phase at Tange
DOI: 10.48597/x2qs-yg47
title: Measurement of Ozone at Ulborg

description: Measurement of Ozone at Ulborg
DOI: 10.48597/x87w-ms79
title: Measurement of Inorganics in air and particle phase at Risoe

description: Measurement of Inorganics in air and particle phase at Risoe
DOI: 10.48597/xmvn-ez5r
title: Measurement of Ozone at Rucava

description: Measurement of Ozone at Rucava
DOI: 10.48597/yscr-3pvf
title: Measurement of Nitrogen_dioxide at Keldsnor

description: Measurement of Nitrogen_dioxide at Keldsnor
DOI: 10.48597/zscf-tc3k
title: Measurement of Zinc at Lahemaa

description: Measurement of Zinc at Lahemaa
DOI: 10.48597/zsz5-8wx7
title: Measurement of Calcium at Rucava

description: Measurement of Calcium at Rucava
DOI: 10.48597/zzpa-3und
title: Measurement of Ozone at Keldsnor

description: Measurement of Ozone at Keldsnor
DOI: 10.48597/zzq7-d979
title: Measurement of Inorganics in air and particle phase at Risoe

description: Measurement of Inorganics in air and particle phase at Risoe
DOI: 10.48597/295u-7bqx
title: BDE_206 at Zeppelin mountain (Ny-Ålesund)

description: Measurement of BDE_206 at Zeppelin mountain (Ny-Ålesund)
DOI: 10.48597/2d7u-r6zr
title: Aerosol_light_backscattering_coefficient at Hohenpeissenberg

description: Measurement of Aerosol_light_backscattering_coefficient at Hohenpeissenberg
DOI: 10.48597/2zg7-euug
title: Inorganics in precipitation at Esrange

description: Measurement of Inorganics in precipitation at Esrange
DOI: 10.48597/33ds-fthy
title: Aerosol_absorption_coefficient at BEO Moussala

description: Measurement of Aerosol_absorption_coefficient at BEO Moussala
DOI: 10.48597/3hex-55rq
title: Inorganics in precipitation at Esrange

description: Measurement of Inorganics in precipitation at Esrange
DOI: 10.48597/3td6-qh3a
title: Relative_humidity at Zeppelin mountain (Ny-Ålesund)

description: Measurement of Relative_humidity at Zeppelin mountain (Ny-Ålesund)
DOI: 10.48597/3uyq-2zer
title: Aerosol light scattering at BEO Moussala

description: Measurement of Aerosol light scattering at BEO Moussala
DOI: 10.48597/4j83-5uu9
title: Aerosol light scattering at Hohenpeissenberg

description: Measurement of Aerosol light scattering at Hohenpeissenberg
DOI: 10.48597/53yc-psmk
title: Aerosol_light_backscattering_coefficient at BEO Moussala

description: Measurement of Aerosol_light_backscattering_coefficient at BEO Moussala
DOI: 10.48597/55bh-fjux
title: BDE_154 at Zeppelin mountain (Ny-Ålesund)

description: Measurement of BDE_154 at Zeppelin mountain (Ny-Ålesund)
DOI: 10.48597/55vf-k429
title: Inorganics in precipitation at Esrange

description: Measurement of Inorganics in precipitation at Esrange
DOI: 10.48597/624f-pcgj
title: Aerosol light scattering at Hohenpeissenberg

description: Measurement of Aerosol light scattering at Hohenpeissenberg
DOI: 10.48597/6bc9-6jyn
title: Inorganics in precipitation at Esrange

description: Measurement of Inorganics in precipitation at Esrange
DOI: 10.48597/6d3y-xukx
title: Inorganics in precipitation at Esrange

description: Measurement of Inorganics in precipitation at Esrange
DOI: 10.48597/6jmk-5q9a
title: BDE_153 at Zeppelin mountain (Ny-Ålesund)

description: Measurement of BDE_153 at Zeppelin mountain (Ny-Ålesund)
DOI: 10.48597/6vm4-kk3p
title: Aerosol light scattering at BEO Moussala

description: Measurement of Aerosol light scattering at BEO Moussala
DOI: 10.48597/7bbw-urd9
title: Sulphate_corrected at Esrange

description: Measurement of Sulphate_corrected at Esrange
DOI: 10.48597/7h9r-9mmj
title: Aerosol_light_backscattering_coefficient at Hohenpeissenberg

description: Measurement of Aerosol_light_backscattering_coefficient at Hohenpeissenberg
DOI: 10.48597/7quz-ugmp
title: BDE_209 at Zeppelin mountain (Ny-Ålesund)

description: Measurement of BDE_209 at Zeppelin mountain (Ny-Ålesund)
DOI: 10.48597/89zk-esru
title: Inorganics in precipitation at Esrange

description: Measurement of Inorganics in precipitation at Esrange
DOI: 10.48597/8j8k-42pb
title: BDE_49+71 at Zeppelin mountain (Ny-Ålesund)

description: Measurement of BDE_49+71 at Zeppelin mountain (Ny-Ålesund)
DOI: 10.48597/95ut-8r98
title: Ozone at Lazaropole

description: Measurement of Ozone at Lazaropole
DOI: 10.48597/98h9-v2f9
title: Aerosol_absorption_coefficient at BEO Moussala

description: Measurement of Aerosol_absorption_coefficient at BEO Moussala
DOI: 10.48597/9mrf-7rkt
title: Aerosol light scattering at BEO Moussala

description: Measurement of Aerosol light scattering at BEO Moussala
DOI: 10.15139/s3/tlhgno
title: Defining safe systems: A review of the state-of-the-practice and leadership summit [R3]

description: The concept of a safe systems approach to traffic safety has been widely embraced by transportation professionals in the United States and beyond, though there remains little clear consensus on what is meant by a safe systems approach, nor how such an approach is to be meaningfully implemented. This effort will entail a review of the literature on safe systems to develop a single, working definition of the concept. This will be accomplished through two activities. The first is a comprehensive review of the literature on safe systems, as well as the related literature on safety-conscious planning and vision zero. The review will specifically seek to answer the following questions: What is meant by a safe systems approach, and how does it differ from conventional safety practices, if at all? Does the concept of safe systems differ across professional boundaries, such as traffic engineering, planning, law enforcement, or public health? If so, how? Are there shared themes or concepts in the different professional disciplines covered under the concept of safe systems? If so, what are they? Is there an interdisciplinary model for the development and execution of safe systems that may be applied to better reduce the incidence of traffic-related deaths and injuries? If not, does the literature suggest a model that might be adopted? The second activity will entail a safe systems summit, tentatively scheduled to occur in early 2018 and will bring together leaders in traffic safety-related disciplines to achieve the three following ends: To share knowledge on the development of a safe systems approach to traffic safety. To develop a shared understanding of safe systems that may be shared across disciplines. To provide the foundation for a book-length manuscript that will serve as a guide for future scholars and professionals seeking to advance safe systems. This manuscript will serve as a product of the Center’s forthcoming activities. The outcomes of the effort will entail a literature review, a safe systems summit, and published proceedings or a book manuscript detailing the results of the summit.
DOI: 10.48597/9n92-nekn
title: Wind_speed at Zeppelin mountain (Ny-Ålesund)

description: Measurement of Wind_speed at Zeppelin mountain (Ny-Ålesund)
DOI: 10.48597/9pna-b73d
title: Aerosol light scattering at BEO Moussala

description: Measurement of Aerosol light scattering at BEO Moussala
DOI: 10.48597/9sg3-hcfw
title: Aerosol light scattering at BEO Moussala

description: Measurement of Aerosol light scattering at BEO Moussala