cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.24631323
title: Supplementary Material for: Effectiveness of mud-pack therapy and mud-bath therapy in osteoarthritis. A systematic review.

description: Background
Osteoarthritis has a tremendous socioeconomic impact in terms of drug spending, hospital admissions, work productivity and temporary or permanent incapacity. Mud therapy has been discussed as a potential conservative treatment options for osteoarthritis. However, findings from several trials still remain controversial.

Methods
We conducted a systematic review of the literature on mud-therapy in the treatment of osteoarthritis in order to investigate the evidence of efficiency of this treatment.

Results
Of the 19 studies included, 15 examined the effects of mud-bath therapy in knee osteoarthritis treatment. We finally systematically reviewed the data obtained from literature and summarized the results on the basis of the main outcomes. The results show significant improvements in function, quality of life and perceived pain for patients with osteoarthritis. 

Conclusion
Results of randomized controlled trials suggest that mud therapy is part of a promising integrated and synergistic multidisciplinary approach in combination with other treatment forms like pharmacotherapy or physiotherapy. Impressing drug- reduction of conventional treatment dosage was reported, possibly resulting in lesser costs and drug-related adverse events.
DOI: 10.6084/m9.figshare.24746898.v1
title: Supplementary Material for: Clinical Impact of Early Tumour Shrinkage in Metastatic or Unresectable Oesophageal Cancer Treated with Pembrolizumab plus Chemotherapy

description: Introduction: Metastatic or unresectable locally advanced oesophageal cancer remains a disease with high mortality. More recently, pembrolizumab plus chemotherapy has been indicated as the first-line treatment for those patients, but the predictive factors for treatment efficacy remain controversial. This study investigated the clinical utility of early tumour shrinkage (ETS) and depth of response (DpR) in metastatic or unresectable oesophageal cancer treated with pembrolizumab plus CF therapy. 
Methods: ETS and DpR, defined as the percent decreases at the second evaluation and the percentage of the maximal tumour shrinkage during treatment, were measured in 53 eligible patients. The ETS and DpR cut-off values were 20% and 30%, respectively, based on survival outcomes. 
Results: Twenty-seven patients (51%) were treatment-naïve, while 26 (49%) had received any treatment before initiating pembrolizumab plus CF therapy. The median progression-free survival (PFS) and overall survival (OS) for ETS ≥20% and &lt;20% were 12.7 and 5.5 months and 14.4 and 8.2 months, and 12.7 and 4.9 months and 14.4 and 8.0 months for DpR ≥30% and &lt;30%, respectively. ETS &lt;20% showed early tumour growth, whereas ETS ≥20% had a good response rate with sufficient longer response duration. In addition, an ETS cut-off of 20% predicted the best overall response and was not associated with prior treatment. In multivariable analysis, ETS ≥20% and DpR ≥30% were independent factors of longer PFS. 
Conclusion: Our findings suggest that an ETS is a promising on-treatment marker for early prediction of further sensitivity to pembrolizumab plus CF therapy.
DOI: 10.6084/m9.figshare.24746790
title: Supplementary Material for: The hearing aid effect across diverse African populations and various hearing device modalities

description: Introduction: The stigma associated with wearing hearing aids, known as the "hearing aid effect," remains a significant issue in hearing healthcare. Despite notable changes in the look and feel of hearing aids over the last decade, little is known about the influence of socioeconomic factors on the perception of different hearing devices in a socioeconomically diverse setting.
Objective: To determine the hearing aid effect across a range of hearing devices and its association with socioeconomic factors, namely area of residence and level of education across African communities.
Method: The study used a cross-sectional design with 322 participants (161 rural, 161 urban); mean age 31.9 years (14.7 SD). Participants rated photographs of seven different styles of devices [standard behind-the-ear hearing aid (BTE HA) with an earmould, mini BTE HA with a slim tube (ST), in-the-canal (ITC) HA, Airpod, receiver-in-canal (RIC), completely-in-canal (CIC) HA, and Personal Sound Amplification Product (PSAP)] worn by a peer model using a validated scale of eight attributes (attractiveness , age, success, hardworking, trustworthiness, intelligence, friendliness, education). The ratings of the BTE HA with earmould were used as a benchmark for comparison.
Results: No hearing aid effect was observed across all participants (n=322) with device ratings ranging between neutral and positive. Significant differences between device ratings were evident for attractiveness for ST and PSAP and trustworthiness for ITC. In terms of residence, urban participants provided more favorable ratings compared to rural participants, with significant differences across three attribute ratings: hardworking for ST; attractiveness, hardworking for ITC; age for RIC and Airpod and hardworking for PSAP. For level of education, significant differences were found for attributes of attractiveness (H = 13.5; p = 0.001) for ITC; attractiveness (H = 14.7, p = 0.001) for PSAP; age (H = 9.5; p = 0.009) for RIC; age (H = 14.3; p&lt;0.001) and intelligence (H = 15.1; p&lt; 0.001) for Airpod and; hardworking (H =11.9, p = 0.003) for ST.
Conclusion: Overall, participants had a neutral to positive view of hearing devices with preferences for less visible, conventionally styled devices. Socioeconomic variables such as educational attainment and geographical location influence perceptions of hearing devices emphasizing the importance of taking these aspects into account when prescribing hearing devices.
DOI: 10.6084/m9.figshare.24746790.v1
title: Supplementary Material for: The hearing aid effect across diverse African populations and various hearing device modalities

description: Introduction: The stigma associated with wearing hearing aids, known as the "hearing aid effect," remains a significant issue in hearing healthcare. Despite notable changes in the look and feel of hearing aids over the last decade, little is known about the influence of socioeconomic factors on the perception of different hearing devices in a socioeconomically diverse setting.
Objective: To determine the hearing aid effect across a range of hearing devices and its association with socioeconomic factors, namely area of residence and level of education across African communities.
Method: The study used a cross-sectional design with 322 participants (161 rural, 161 urban); mean age 31.9 years (14.7 SD). Participants rated photographs of seven different styles of devices [standard behind-the-ear hearing aid (BTE HA) with an earmould, mini BTE HA with a slim tube (ST), in-the-canal (ITC) HA, Airpod, receiver-in-canal (RIC), completely-in-canal (CIC) HA, and Personal Sound Amplification Product (PSAP)] worn by a peer model using a validated scale of eight attributes (attractiveness , age, success, hardworking, trustworthiness, intelligence, friendliness, education). The ratings of the BTE HA with earmould were used as a benchmark for comparison.
Results: No hearing aid effect was observed across all participants (n=322) with device ratings ranging between neutral and positive. Significant differences between device ratings were evident for attractiveness for ST and PSAP and trustworthiness for ITC. In terms of residence, urban participants provided more favorable ratings compared to rural participants, with significant differences across three attribute ratings: hardworking for ST; attractiveness, hardworking for ITC; age for RIC and Airpod and hardworking for PSAP. For level of education, significant differences were found for attributes of attractiveness (H = 13.5; p = 0.001) for ITC; attractiveness (H = 14.7, p = 0.001) for PSAP; age (H = 9.5; p = 0.009) for RIC; age (H = 14.3; p&lt;0.001) and intelligence (H = 15.1; p&lt; 0.001) for Airpod and; hardworking (H =11.9, p = 0.003) for ST.
Conclusion: Overall, participants had a neutral to positive view of hearing devices with preferences for less visible, conventionally styled devices. Socioeconomic variables such as educational attainment and geographical location influence perceptions of hearing devices emphasizing the importance of taking these aspects into account when prescribing hearing devices.
DOI: 10.6084/m9.figshare.24755283
title: Supplementary Material for: Knowledge of day and time contact preferences assists in successful telephone follow-up

description: Objectives: There is limited evidence as to whether knowing a participant’s contact preferences improves completion of telephone assessments in clinical trials. We examined i) participants’ preferences for telephone contact and these preferences related to day and time of actual contact; ii) the number of contact attempts to successfully complete telephone assessments; iii) the association between participant characteristics and successful telephone contacts. 
Materials and Methods: A prospective observational study nested within the Recovery-focused Community support to Avoid readmissions and improve participant after Stroke (ReCAPS) trial was undertaken. Information was collected on preferences (set days of the week, any weekday, morning, afternoon, evening, anytime) for assessment calls at 3 months post randomization. Descriptive statistics and logistic regression were used. 
Results: Of the 232 participants (average age 66 years, 69% male), 59% preferred calls on any weekday. Wednesday (26%) and Monday (21%) and mornings (49%) were preferred. Approximately 70% of telephone calls were completed within three contact attempts. Approximately 60% of all calls were completed on participants’ preferred day and time. There was no association between participant characteristics (sex, age, employment status, and living alone) and the number of contact attempts made for the telephone call assessment. There were no participant characteristics associated with the successful completion of assessments on participants’ preferred time/day.
Conclusions: We provide new evidence, based on a case study in stroke, highlighting the importance of knowing a participant’s preferred contact day and time for the timely completion of assessments via telephone call.
DOI: 10.6084/m9.figshare.24755283.v1
title: Supplementary Material for: Knowledge of day and time contact preferences assists in successful telephone follow-up

description: Objectives: There is limited evidence as to whether knowing a participant’s contact preferences improves completion of telephone assessments in clinical trials. We examined i) participants’ preferences for telephone contact and these preferences related to day and time of actual contact; ii) the number of contact attempts to successfully complete telephone assessments; iii) the association between participant characteristics and successful telephone contacts. 
Materials and Methods: A prospective observational study nested within the Recovery-focused Community support to Avoid readmissions and improve participant after Stroke (ReCAPS) trial was undertaken. Information was collected on preferences (set days of the week, any weekday, morning, afternoon, evening, anytime) for assessment calls at 3 months post randomization. Descriptive statistics and logistic regression were used. 
Results: Of the 232 participants (average age 66 years, 69% male), 59% preferred calls on any weekday. Wednesday (26%) and Monday (21%) and mornings (49%) were preferred. Approximately 70% of telephone calls were completed within three contact attempts. Approximately 60% of all calls were completed on participants’ preferred day and time. There was no association between participant characteristics (sex, age, employment status, and living alone) and the number of contact attempts made for the telephone call assessment. There were no participant characteristics associated with the successful completion of assessments on participants’ preferred time/day.
Conclusions: We provide new evidence, based on a case study in stroke, highlighting the importance of knowing a participant’s preferred contact day and time for the timely completion of assessments via telephone call.
DOI: 10.6084/m9.figshare.24935160
title: DATA

description: DATA for Travel and Leisure Stocks , Partisan Conflict and Trade & Immigration Policy Uncertainty
DOI: 10.6084/m9.figshare.24935160.v1
title: DATA

description: DATA for Travel and Leisure Stocks , Partisan Conflict and Trade & Immigration Policy Uncertainty
DOI: 10.6084/m9.figshare.22215361.v1
title: RNA-seq data analysis

description: RNA-seq results
DOI: 10.6084/m9.figshare.24559348
title: Supplementary Material for: CD15 is a risk predictor and a novel target in clear cell renal cell carcinoma

description: Introduction: Tumor cells use adhesion molecules like CD15 or sialylCD15 (sCD15) for metastatic spreading. We analyzed the expression of CD15 and sCD15 in clear cell renal cell carcinoma (ccRCC) regarding prognosis.
Methods: A tissue microarray containing tissue specimens of 763 patients with ccRCC was immunohistochemically stained for CD15 and sCD15, their expression quantified using digital image analysis and the impact on patients’ survival analyzed. The cell lines 769p and 786o were stimulated with CD15 or control antibody in vitro and the effects on pathways activating AP-1 and tumor cell migration examined.
Results: ccRCC showed a broad range of CD15 and sCD15 expression. A high CD15 expression was significantly associated with favorable outcome (p&lt;0.01) and low-grade tumor differentiation (p&lt;0.001), whereas sCD15 had no significant prognostic value. Tumors with synchronous distant metastasis had a significantly lower CD15 expression compared to tumors without any (p&lt;0.001) or with metachronous metastasis (p&lt;0.01). Tumor cell migration was significantly reduced after CD15 stimulation in vitro, but there were no major effects on activating pathways of AP-1.
Conclusion: CD15, but not sCD15, qualifies as a biomarker for risk stratification and as an interesting novel target in ccRCC. Moreover, the data indicates a contribution of CD15 to metachronous metastasis. Further research is warranted to decipher the intracellular pathways of CD15 signaling in ccRCC in order to characterize the CD15 effects on ccRCC more precisely.
DOI: 10.6084/m9.figshare.24559348.v1
title: Supplementary Material for: CD15 is a risk predictor and a novel target in clear cell renal cell carcinoma

description: Introduction: Tumor cells use adhesion molecules like CD15 or sialylCD15 (sCD15) for metastatic spreading. We analyzed the expression of CD15 and sCD15 in clear cell renal cell carcinoma (ccRCC) regarding prognosis.
Methods: A tissue microarray containing tissue specimens of 763 patients with ccRCC was immunohistochemically stained for CD15 and sCD15, their expression quantified using digital image analysis and the impact on patients’ survival analyzed. The cell lines 769p and 786o were stimulated with CD15 or control antibody in vitro and the effects on pathways activating AP-1 and tumor cell migration examined.
Results: ccRCC showed a broad range of CD15 and sCD15 expression. A high CD15 expression was significantly associated with favorable outcome (p&lt;0.01) and low-grade tumor differentiation (p&lt;0.001), whereas sCD15 had no significant prognostic value. Tumors with synchronous distant metastasis had a significantly lower CD15 expression compared to tumors without any (p&lt;0.001) or with metachronous metastasis (p&lt;0.01). Tumor cell migration was significantly reduced after CD15 stimulation in vitro, but there were no major effects on activating pathways of AP-1.
Conclusion: CD15, but not sCD15, qualifies as a biomarker for risk stratification and as an interesting novel target in ccRCC. Moreover, the data indicates a contribution of CD15 to metachronous metastasis. Further research is warranted to decipher the intracellular pathways of CD15 signaling in ccRCC in order to characterize the CD15 effects on ccRCC more precisely.
DOI: 10.6084/m9.figshare.22297816
title: Presence of onco-fetal neighborhoods in hepatocellular carcinoma is associated with relapse and response to immunotherapy

description: The HCC01 and HCC03 Stereo-seq data have been deposited in the China National GeneBank Sequence Archive (CNSA) under accession code CNP0004497. The M311 and M316 Stereo-seq data have been deposited in the Sequence Read Archive (SRA) under accession code PRJNA1005053. The CoxMx data have been deposited in the under accession code. The original data used to construct the HCC atlas are available with accession codes GSE156337, GSE149614, GSE151530, GSE212046 (GEO), HRA000069 (Genome Sequence Archive) and CNP0000650 (CNSA). The original data of PLANET cohort and GO30140 and IMbrave150 trials are available with accession codes EGAS00001003813 and EGAS00001005503 (European Genome-phenome Archive). The TCGA LIHC datasets were downloaded from UCSC Xena (http://xena.ucsc.edu/). All processed expression data have been uploaded to figshare, which can be visited through the following private links: HCC Atlas, https://doi.org/10.6084/m9.figshare.22332568; Onco-fetal CAF Identification, https://doi.org/ 10.6084/m9.figshare.22332655; HCC01 and HCC03 Stereo-seq Data, https://doi.org/10.6084/m9.figshare.22332223; Nanostring CosMx Data, https://doi.org/10.6084/m9.figshare.23972991; PLANET corhort Data, https://doi.org/10.6084/m9.figshare.23732370; HCC and Fetal Liver Nanostring DSP Data, https://doi.org/10.6084/m9.figshare.22332397; HCC Immunotherapy Stereo-seq Data, https://doi.org/10.6084/m9.figshare.22332352. Source data for Fig. 1-8 and Extended Data Fig. 1-10 have been provided as Source Data files. All other data supporting the findings of this study are available from the corresponding author upon reasonable request.
DOI: 10.6084/m9.figshare.21197953.v1
title: Vitamin B12 produced by gut bacteria modulates cholinergic signaling

description: Research Article
DOI: 10.6084/m9.figshare.22215361
title: RNA-seq data analysis

description: RNA-seq results
DOI: 10.6084/m9.figshare.21197953
title: Vitamin B12 produced by gut bacteria modulates cholinergic signaling

description: Research Article
DOI: 10.6084/m9.figshare.21191953.v1
title: supporting data

description: the supporting data is original data for the manuscript
DOI: 10.6084/m9.figshare.21191953
title: supporting data

description: the supporting data is original data for the manuscript
DOI: 10.6084/m9.figshare.22672519.v1
title: Holographic augmented reality glasses using exit-pupil expanding waveguide

description: Supplementary Video (Visualization of focus change)
Supplementary Data (Trained models )
DOI: 10.6084/m9.figshare.22672519
title: Holographic augmented reality glasses using exit-pupil expanding waveguide

description: Supplementary Video (Visualization of focus change)
Supplementary Data (Trained models )
DOI: 10.6084/m9.figshare.23536794.v1
title: Deep learning-driven fragment ion series classification enables highly precise and sensitive de novo peptide sequencing

description: Data to create figures for the manuscript.
DOI: 10.6084/m9.figshare.24589425.v1
title: Electrical tuning of branched flow of light

description: The measured optical intensity distributions for various electrical gate voltages and the extracted fidelity and statistical properties, etc.
DOI: 10.6084/m9.figshare.24495151.v1
title: The Evolution of Centriole Degradation in Mouse Sperm

description: This file contains the data source for the paper.
DOI: 10.6084/m9.figshare.24495151
title: The Evolution of Centriole Degradation in Mouse Sperm

description: This file contains the data source for the paper.
DOI: 10.6084/m9.figshare.24249760.v1
title: Quantum plasmonics pushes chiral sensing limit to single molecules: a paradigm for chiral biodetections

description: This is the NMR datasets support of the publication entitled "Quantum plasmonics pushes chiral sensing limit to single molecules: a paradigm for chiral biodetections" in Nature Communications It can only be viewed with TopSpin
DOI: 10.6084/m9.figshare.24787485.v1
title: Mammalian cell growth characterisation by a non-invasive plate reader assay

description: The file contains all the source data used to generate the figures in the above title manuscript
DOI: 10.6084/m9.figshare.24589425
title: Electrical tuning of branched flow of light

description: The measured optical intensity distributions for various electrical gate voltages and the extracted fidelity and statistical properties, etc.
DOI: 10.6084/m9.figshare.24217176.v1
title: Reprogramming biocatalytic futile cycles through computational engineering of stereochemical promiscuity to create an amine racemase

description: Raw data for figures
DOI: 10.6084/m9.figshare.24499144.v1
title: Leafhopper salivary vitellogenin mediates virus transmission to plant phloem

description: Effect of salivary vitellogenin of leafhopper infected by rice dwarf virus on plant H2O2 burst and metabolism, as well as GST catalyzing reaction.
DOI: 10.6084/m9.figshare.23536794
title: Deep learning-driven fragment ion series classification enables highly precise and sensitive de novo peptide sequencing

description: Data to create figures for the manuscript.
DOI: 10.6084/m9.figshare.23545113.v1
title: Terminal modifications independent cell-free RNA sequencing enables sensitive early cancer detection and classification

description: Transcriptome-wide characterizations of the plasma cfRNA from 165 lung cancer, 30 breast cancer, 37 colorectal cancer, 55 gastric cancer, 15 liver cancer patients, and 133 cancer-free participants
DOI: 10.6084/m9.figshare.23545113
title: Terminal modifications independent cell-free RNA sequencing enables sensitive early cancer detection and classification

description: Transcriptome-wide characterizations of the plasma cfRNA from 165 lung cancer, 30 breast cancer, 37 colorectal cancer, 55 gastric cancer, 15 liver cancer patients, and 133 cancer-free participants
DOI: 10.6084/m9.figshare.22634365.v1
title: Modular Access to Chiral Bridged Piperidine-γ-butyrolactones via Catalytic Asymmetric Allylation/aza-Prins Cyclization/Lactonization Sequences

description: cif files for chiral products
DOI: 10.6084/m9.figshare.22634365
title: Modular Access to Chiral Bridged Piperidine-γ-butyrolactones via Catalytic Asymmetric Allylation/aza-Prins Cyclization/Lactonization Sequences

description: cif files for chiral products
DOI: 10.6084/m9.figshare.24499144
title: Leafhopper salivary vitellogenin mediates virus transmission to plant phloem

description: Effect of salivary vitellogenin of leafhopper infected by rice dwarf virus on plant H2O2 burst and metabolism, as well as GST catalyzing reaction.
DOI: 10.6084/m9.figshare.24787485
title: Mammalian cell growth characterisation by a non-invasive plate reader assay

description: The file contains all the source data used to generate the figures in the above title manuscript
DOI: 10.6084/m9.figshare.24523219.v1
title: Bioinspired structural hydrogels with highly ordered hierarchical orientations by flow-induced alignment of nanofibrils

description: Source data for "Bioinspired structural hydrogels with highly ordered hierarchical orientations by flow-induced alignment of nanofibrils"
DOI: 10.6084/m9.figshare.24523219
title: Bioinspired structural hydrogels with highly ordered hierarchical orientations by flow-induced alignment of nanofibrils

description: Source data for "Bioinspired structural hydrogels with highly ordered hierarchical orientations by flow-induced alignment of nanofibrils"
DOI: 10.6084/m9.figshare.22716370.v1
title: Data

description: The data supporting the findings of this study.
DOI: 10.6084/m9.figshare.22716370
title: Data

description: The data supporting the findings of this study.