cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.7274/27184629.v1
title: Analyzing Murine Primary Mesothelial Cell Proteomics to Identify Candidate Proteins Contributing to Gender Differences in Colorectal Cancer Peritoneal Metastatic Receptivity with Aging

description: Cancer is a disease that predominantly affects older individuals. While age remains one of the most significant risk factors for cancer and metastasis, the biological sex of the host also plays a crucial role in influencing metastasis and survival outcomes.. Specifically in colorectal cancer (CRC), both cancer incidence and deaths from metastatic disease are higher in males relative to females. The study hypothesizes that gender- and/or age-related differences in peritoneal mesothelial cells impact the interaction between tumor and mesothelial cells (MC) early in metastatic dissemination, influencing CRC metastasis success. 
In a comparative analysis using female or male young mice (3-6 months, equivalent to human 20-30 years old, FY and MY) and aged mice (20-23 months, equivalent to human 60-67 years old, FA and MA) in an intra-peritoneal (ip) metastasis model, results show that aged males exhibit the highest metastatic tumor burden which aligns with human epidemiological data. The results also show CRC selectively targets adipose tissues covered by visceral peritoneum. Additionally, the omentum shows gender-specific differences in aged groups.
To further explore these gender and age effects, the study investigates the proteome of murine primary peritoneal mesothelial cells (MPPMCs) isolated from young and aged male and female mice. In each cohort, ~2000 proteins and ~1000 protein groups were identified. Proteomic analysis revealed differences in protein expression based on gender and age, providing baseline data for future studies on how these factors regulate MC homeostasis and influence the initiation of peritoneal diseases. 
One of the candidate proteins identified, protein tyrosine phosphatase type IVA 1 (Prl-1), has been characterized in its function in CRC metastasis. Prl-1, expressed exclusively in aged male mice, is found to promote CRC metastasis by aiding initial adhesion of tumor cells to mesothelial cells. The study identifies key signaling pathways, including RhoA-GTPase and src-FAK/p130cas, that are activated by Prl-1. A Prl-1 inhibitor, CMPD-43, shows promise in reducing cell adhesion and migration. The findings suggest that targeting Prl-1 could offer new therapeutic avenues to impede CRC progression and metastasis.
DOI: 10.7274/27281436
title: Nanopore-Enabled Determinations of Drug Impurities and Biomarkers Using Hydrophobically-Gated Systems and 3D-Printed Point-of-Care Assays

description: This work explores the usage of block copolymer – nanopore electrode arrays as hydrophobically-gated biosensors and 3D-printed microfluidic sensors as point-of-care analytical devices to detect oxidative impurities in drug formulations and clinical biomarkers in body fluids non-invasively. By combining the measurement advantages of electroanalytical chemistry with those arising from volume confinement inside nanopores, the sensitivity, selectivity, and robustness of electrochemical sensors improves significantly. The usage of thin membrane layers that exhibit hydrophobic gating properties enables potential control over mass transport and achieves effective confinement of analytes to attoliter volumes. To overcome the inherent limitation of low electrochemical selectivity, enzymes are incorporated for electrochemical signal transduction through redox mediation cascades, which are utilized to detect 4-ethyl phenol, a model environmental pollutant, and lipid degradation products in lipid nanoparticle formulations. Furthermore, direct 3D-printing techniques are deployed to realize the cost-effective, high-throughput fabrication of fully integrated microfluidic biosensors to detect biomarkers in sweat and oxidative impurities in drug formulations. The work reported here presents novel sensing modalities by combining mass-transport control on the nanoscale with electrochemical analysis under volume confinement, and the fabrication of 3D-printed microfluidic electrochemical sensors presents important improvements in electrochemical point-of-care assays that are applied toward real-time health monitoring and impurity screening in drug manufacturing.
DOI: 10.7274/27281436.v1
title: Nanopore-Enabled Determinations of Drug Impurities and Biomarkers Using Hydrophobically-Gated Systems and 3D-Printed Point-of-Care Assays

description: This work explores the usage of block copolymer – nanopore electrode arrays as hydrophobically-gated biosensors and 3D-printed microfluidic sensors as point-of-care analytical devices to detect oxidative impurities in drug formulations and clinical biomarkers in body fluids non-invasively. By combining the measurement advantages of electroanalytical chemistry with those arising from volume confinement inside nanopores, the sensitivity, selectivity, and robustness of electrochemical sensors improves significantly. The usage of thin membrane layers that exhibit hydrophobic gating properties enables potential control over mass transport and achieves effective confinement of analytes to attoliter volumes. To overcome the inherent limitation of low electrochemical selectivity, enzymes are incorporated for electrochemical signal transduction through redox mediation cascades, which are utilized to detect 4-ethyl phenol, a model environmental pollutant, and lipid degradation products in lipid nanoparticle formulations. Furthermore, direct 3D-printing techniques are deployed to realize the cost-effective, high-throughput fabrication of fully integrated microfluidic biosensors to detect biomarkers in sweat and oxidative impurities in drug formulations. The work reported here presents novel sensing modalities by combining mass-transport control on the nanoscale with electrochemical analysis under volume confinement, and the fabrication of 3D-printed microfluidic electrochemical sensors presents important improvements in electrochemical point-of-care assays that are applied toward real-time health monitoring and impurity screening in drug manufacturing.
DOI: 10.7274/25527736
title: Infrared Photothermal Heterodyne Imaging for the Characterization of Micro- and Nanoplastic Environmental Contaminants

description: This dissertation explores the use of Infrared Photothermal Heterodyne Imaging (IR-PHI) in characterizing Micro and Nanoplastics (MNPs) as environmental contaminants. It begins by examining the environmental and health challenges posed by MNPs, defining their origin and distinguishing between primary and secondary types. The global prevalence of MNPs and their ecotoxicological impact, along with concerns about their effects on human health, are highlighted.
 The introductory chapter also reviews the detection and characterization of MNPs, discussing their physical and chemical properties, current analytical tools, and the limitations of existing techniques. It introduces IR-PHI as an emerging method that could overcome some of these limitations, offering a more integrated and accurate approach to MNP analysis.
 The second chapter delves into the development of IR-PHI, from its conceptual origins to its practical applications in various fields. It focuses on the use of IR-PHI in identifying and analyzing MNPs, presenting case studies like the analysis of MNPs from nylon tea bags and other environmental samples. The challenges of IR-PHI, such as slow imaging speed, are discussed, along with the future development of widefield IR-PHI (wIR-PHI) for more efficient environmental analysis.
 The third chapter discusses the advancement of wIR-PHI, a technique that addresses the slow imaging speed of traditional IR-PHI through synchronized nanosecond pump pulses and a high-speed complementary metal–oxide–semiconductor (CMOS) camera. This enables rapid, large-area mid-infrared photothermal image acquisition. The chapter demonstrates wIR-PHI's capabilities in fast IR imaging of individual nanoparticles, establishing a new benchmark in detection sensitivity and temporal resolution.
 The fourth chapter emphasizes the transformative role of IR-PHI and wIR-PHI in environmental science, particularly in monitoring MNPs. It discusses the applications of these techniques in analyzing various materials and products, highlighting the need for increased regulatory attention and public awareness. The chapter concludes by stressing the importance of understanding and addressing MNP contamination, particularly among influential communities, to drive meaningful environmental change.
DOI: 10.7274/25527736.v1
title: Infrared Photothermal Heterodyne Imaging for the Characterization of Micro- and Nanoplastic Environmental Contaminants

description: This dissertation explores the use of Infrared Photothermal Heterodyne Imaging (IR-PHI) in characterizing Micro and Nanoplastics (MNPs) as environmental contaminants. It begins by examining the environmental and health challenges posed by MNPs, defining their origin and distinguishing between primary and secondary types. The global prevalence of MNPs and their ecotoxicological impact, along with concerns about their effects on human health, are highlighted.
 The introductory chapter also reviews the detection and characterization of MNPs, discussing their physical and chemical properties, current analytical tools, and the limitations of existing techniques. It introduces IR-PHI as an emerging method that could overcome some of these limitations, offering a more integrated and accurate approach to MNP analysis.
 The second chapter delves into the development of IR-PHI, from its conceptual origins to its practical applications in various fields. It focuses on the use of IR-PHI in identifying and analyzing MNPs, presenting case studies like the analysis of MNPs from nylon tea bags and other environmental samples. The challenges of IR-PHI, such as slow imaging speed, are discussed, along with the future development of widefield IR-PHI (wIR-PHI) for more efficient environmental analysis.
 The third chapter discusses the advancement of wIR-PHI, a technique that addresses the slow imaging speed of traditional IR-PHI through synchronized nanosecond pump pulses and a high-speed complementary metal–oxide–semiconductor (CMOS) camera. This enables rapid, large-area mid-infrared photothermal image acquisition. The chapter demonstrates wIR-PHI's capabilities in fast IR imaging of individual nanoparticles, establishing a new benchmark in detection sensitivity and temporal resolution.
 The fourth chapter emphasizes the transformative role of IR-PHI and wIR-PHI in environmental science, particularly in monitoring MNPs. It discusses the applications of these techniques in analyzing various materials and products, highlighting the need for increased regulatory attention and public awareness. The chapter concludes by stressing the importance of understanding and addressing MNP contamination, particularly among influential communities, to drive meaningful environmental change.
DOI: 10.15468/dl.z56eht
title: Occurrence Download

description: A dataset containing 1 species occurrences available in GBIF matching the query:
{
 "and" : [
 "DatasetKey is Revision der europäischen Gattungen und Arten der Familie Brachychthoniidae (Acari, Oribatei) Teil 2. Mixochthonius Niedbala, 1972, Neobrachychthonius nov. gen., Synchthonius v. d. Hammen, 1952, Poecilochthonius Balogh, 1943, Brachychthonius Berlese, 1910, Brachychochthonius Jacot, 1938",
 "Country is Croatia"
 ]
}

 The dataset includes 1 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0008076-241107131044228/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.7274/26308762
title: Different Shapes of the Future: Perovskites and Chalcohalides Semiconductor Nanocrystals

description: The demand for sustainable energy sources has driven extensive research efforts in various directions, unfolding a new era for emerging semiconductor materials. Over the past few decades, semiconductor materials have undergone thorough investigation for their potential applications in diverse devices, starting with solar cells and ending up with TVs. However, before these materials can be commercialized, scientists must address the challenges they encounter.
This thesis focuses on novel materials synthesis and characterization, as well as discussing potential applications and strategies for mitigating intrinsic and extrinsic instabilities in semiconductor materials. Specifically, it addresses:
1) Perovskite colloidal nanocrystals which show promise for solar cell and photodetector applications but exhibit instability under sunlight. Proposed solutions include methods to prevent anion segregation.
2) Exploration of a new class of materials known as chalcohalides, where novel materials have been synthesized and characterized for potential application in light-harvesting systems.
By touching these areas, the thesis aims to contribute to the advancement of sustainable energy technologies by providing insights into the synthesis, characterization, and application of semiconductor materials.
DOI: 10.7274/26308762.v1
title: Different Shapes of the Future: Perovskites and Chalcohalides Semiconductor Nanocrystals

description: The demand for sustainable energy sources has driven extensive research efforts in various directions, unfolding a new era for emerging semiconductor materials. Over the past few decades, semiconductor materials have undergone thorough investigation for their potential applications in diverse devices, starting with solar cells and ending up with TVs. However, before these materials can be commercialized, scientists must address the challenges they encounter.
This thesis focuses on novel materials synthesis and characterization, as well as discussing potential applications and strategies for mitigating intrinsic and extrinsic instabilities in semiconductor materials. Specifically, it addresses:
1) Perovskite colloidal nanocrystals which show promise for solar cell and photodetector applications but exhibit instability under sunlight. Proposed solutions include methods to prevent anion segregation.
2) Exploration of a new class of materials known as chalcohalides, where novel materials have been synthesized and characterized for potential application in light-harvesting systems.
By touching these areas, the thesis aims to contribute to the advancement of sustainable energy technologies by providing insights into the synthesis, characterization, and application of semiconductor materials.
DOI: 10.7274/26195678
title: Reactivity of Iron Oxide Nanoparticle Surfaces: Understanding the Role of Crystallite Size and Morphology on Contaminant Behavior

description: Iron oxide nanoparticles, such as hematite (a-Fe2O3) and magnetite (Fe3O4), are found in the natural environment. Factors such as primary crystallite size and morphology can impact iron oxide nanoparticle reactivity and their interactions with contaminants. Currently, there are knowledge gaps related to how iron oxide nanoparticles behave in the environment in the presence of contaminants. To fill these knowledge gaps, the work presented here describes the reactivity of iron oxide nanoparticle surfaces as a function of crystallite size and morphology. It explores three themes relevant to understanding the reactivity of iron oxide nanoparticle surfaces: (i) understanding the effects of vacuum and oxygen annealing on nanoparticle surfaces as a function of crystallite size, (ii) interrogating the role of crystallite size on sorption and retention of Pu(V/VI), and (iii) investigating the impacts of nanoscale morphology on Pu(V/VI) sorption. The results of the first area of research show that carbon-mediated iron reduction increases with decreasing crystallite size after vacuum annealing, whereas an oxygen annealing + vacuum annealing step changes the extent of iron reduction caused by carbon. In the second area of research, the constant mass experimental results show there were changes in plutonium sorption and retention based on crystallite size and mineral type. Meanwhile, constant surface area experimental results show that there are no changes in plutonium sorption and retention regardless of crystallite size. Finally, the results of the third area of research show that morphology impacts the sorption of Pu(V/VI). It was found that (i) surface mediated reduction of Pu(V/VI) was observed on all morphologies and (ii) Pu sorbed species and Pu oxide nanoparticles form on platelet and rhombohedral morphologies. The result of this work provides insight into the impacts of crystallite size and morphology on contaminant behavior.
DOI: 10.7274/26195678.v1
title: Reactivity of Iron Oxide Nanoparticle Surfaces: Understanding the Role of Crystallite Size and Morphology on Contaminant Behavior

description: Iron oxide nanoparticles, such as hematite (a-Fe2O3) and magnetite (Fe3O4), are found in the natural environment. Factors such as primary crystallite size and morphology can impact iron oxide nanoparticle reactivity and their interactions with contaminants. Currently, there are knowledge gaps related to how iron oxide nanoparticles behave in the environment in the presence of contaminants. To fill these knowledge gaps, the work presented here describes the reactivity of iron oxide nanoparticle surfaces as a function of crystallite size and morphology. It explores three themes relevant to understanding the reactivity of iron oxide nanoparticle surfaces: (i) understanding the effects of vacuum and oxygen annealing on nanoparticle surfaces as a function of crystallite size, (ii) interrogating the role of crystallite size on sorption and retention of Pu(V/VI), and (iii) investigating the impacts of nanoscale morphology on Pu(V/VI) sorption. The results of the first area of research show that carbon-mediated iron reduction increases with decreasing crystallite size after vacuum annealing, whereas an oxygen annealing + vacuum annealing step changes the extent of iron reduction caused by carbon. In the second area of research, the constant mass experimental results show there were changes in plutonium sorption and retention based on crystallite size and mineral type. Meanwhile, constant surface area experimental results show that there are no changes in plutonium sorption and retention regardless of crystallite size. Finally, the results of the third area of research show that morphology impacts the sorption of Pu(V/VI). It was found that (i) surface mediated reduction of Pu(V/VI) was observed on all morphologies and (ii) Pu sorbed species and Pu oxide nanoparticles form on platelet and rhombohedral morphologies. The result of this work provides insight into the impacts of crystallite size and morphology on contaminant behavior.
DOI: 10.18742/25887853
title: PSYD_0104: KCL

description: <i>This record is part of the Psy-ShareD database. The Psy-ShareD database will host pre-existing structural MRI data collected at different global sites that will be suitable for region of interest, voxel-based morphometry, cortical thickness and surface area analytical approaches. To access this database, complete the Data Access Request Form by following the link on this page under the Licence ‘Psy-ShareD Data Access Request’. For more information, follow the link listed in Related Materials.</i><b>Schizotypy study using O-LIFE instrument to measure high and low schizotypy in healthy controls.</b><b>Contributors and PI’s: </b>Veena KumariInstitute of Psychiatry, Psychology and Neuroscience (IOPPN), King’s College London, U.K<b>Key Details & Variables</b><b>Data Type</b>Feature Data<b>Age Range</b>19-53<b>Number of Participants</b>26<b>Diagnostic Criteria</b>High/Low SCZTY<b>Number of Clinical Subjects</b>26<b>Number of Clinical Subjects (follow up)</b>N/A<b>Number of Control Subjects</b>N/A<b>Number of Control Subjects (follow up)</b>N/A<b>Demographic Information</b>Age, Sex, Ethnicity, Education, SES<b>Clinical Measures</b>O-LIFE<b>Cognitive Measures</b>NART IQ<b>Clinical Functioning Measures</b>N/A<b>Antipsychotic Medication Information Recorded</b>No<b>Antipsychotic Medication Name/ Antipsychotic Type</b>N/A<b>Antipsychotic Dose Recorded</b>N/A<b>CPZ Equivalents Recorded</b>N/A<b>Other Medication Information Available</b>No<b>Recreational Drug/ Alcohol Use</b>Yes<i>Note: the above table features key details and variables and is not an exhaustive list.</i>
DOI: 10.18742/25887853.v1
title: PSYD_0104: KCL

description: <i>This record is part of the Psy-ShareD database. The Psy-ShareD database will host pre-existing structural MRI data collected at different global sites that will be suitable for region of interest, voxel-based morphometry, cortical thickness and surface area analytical approaches. To access this database, complete the Data Access Request Form by following the link on this page under the Licence ‘Psy-ShareD Data Access Request’. For more information, follow the link listed in Related Materials.</i><b>Schizotypy study using O-LIFE instrument to measure high and low schizotypy in healthy controls.</b><b>Contributors and PI’s: </b>Veena KumariInstitute of Psychiatry, Psychology and Neuroscience (IOPPN), King’s College London, U.K<b>Key Details & Variables</b><b>Data Type</b>Feature Data<b>Age Range</b>19-53<b>Number of Participants</b>26<b>Diagnostic Criteria</b>High/Low SCZTY<b>Number of Clinical Subjects</b>26<b>Number of Clinical Subjects (follow up)</b>N/A<b>Number of Control Subjects</b>N/A<b>Number of Control Subjects (follow up)</b>N/A<b>Demographic Information</b>Age, Sex, Ethnicity, Education, SES<b>Clinical Measures</b>O-LIFE<b>Cognitive Measures</b>NART IQ<b>Clinical Functioning Measures</b>N/A<b>Antipsychotic Medication Information Recorded</b>No<b>Antipsychotic Medication Name/ Antipsychotic Type</b>N/A<b>Antipsychotic Dose Recorded</b>N/A<b>CPZ Equivalents Recorded</b>N/A<b>Other Medication Information Available</b>No<b>Recreational Drug/ Alcohol Use</b>Yes<i>Note: the above table features key details and variables and is not an exhaustive list.</i>
DOI: 10.15468/dl.nc9s3x
title: Occurrence Download

description: A dataset containing 1 species occurrences available in GBIF matching the query:
{
 "and" : [
 "DatasetKey is Revisions to the faunas of Andrena of the Iberian Peninsula and Morocco with the descriptions of four new species (Hymenoptera: Andrenidae)",
 "Country is Croatia"
 ]
}

 The dataset includes 1 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0008077-241107131044228/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.tczr5u
title: Occurrence Download

description: A dataset containing 1 species occurrences available in GBIF matching the query:
{
 "and" : [
 "DatasetKey is Rutgers University, Chrysler Herbarium - Macroalgae Collection",
 "Country is Croatia"
 ]
}

 The dataset includes 1 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0008078-241107131044228/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.66hb2n
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Polyommatus icarus (von Rottemburg, 1775)",
 "Year is 46",
 "Country is Netherlands"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0008079-241107131044228/datasets/export for details.