DOI: 10.7270/q2hq412b
title: BindingDB Entry 50040861: Discovery of 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-(tert-butyl)pyridine-3-sulfonamide (CZC24758), as a potent, orally bioavailable and selective inhibitor of PI3K for the treatment of inflammatory disease.

description: Small molecule binding data for protein 3-phosphoinositide dependent protein kinase-1, 5'-AMP-activated protein kinase catalytic subunit alpha-1, AMPK subunit alpha-2, Activin receptor type-1, Activin receptor type-1B, Activin receptor type-2A, Activin receptor type-2B, Activin receptor-like kinase 3 (ALK-3), Adaptor-associated kinase, Apoptosis Signal-regulating Kinase 1 (ASK1), Aurora kinase B/Inner centromere protein, BMP-2-inducible protein kinase, Bromodomain-containing protein 2, Bromodomain-containing protein 3, Bromodomain-containing protein 4, CDK7/Cyclin H/MNAT1, CaM kinase I delta, CaM kinase II, CaM kinase IV, CaM-kinase kinase alpha, CaM-kinase kinase beta, Casein Kinase II, Casein kinase I, Casein kinase I delta/epsilon, Casein kinase I isoform alpha (CK1 Alpha), Casein kinase I isoform delta, Casein kinase I isoform gamma-3, Casein kinase II, Chaperone activity of bc1 complex-like, mitochondrial, Cyclin-Dependent Kinase 5 (CDK5), Cyclin-dependent kinase 1, Cyclin-dependent kinase 2, Cyclin-dependent kinase 6, Cyclin-dependent kinase 9, Dual specificity mitogen-activated protein kinase kinase 1, Dual specificity mitogen-activated protein kinase kinase 2, Dual specificity mitogen-activated protein kinase kinase 5, Dual specificity protein kinase CLK2, Dual specificity testis-specific protein kinase 1, Dual specificity testis-specific protein kinase 2, Dual specificty protein kinase CLK1, Ephrin receptor, Ephrin type-A receptor 3 (EPHA3), Ephrin type-B receptor 4 (EphB4), Epidermal growth factor receptor, Epithelial discoidin domain-containing receptor 1, Eukaryotic translation initiation factor 2-alpha kinase 1, Eukaryotic translation initiation factor 2-alpha kinase 4, Fibroblast growth factor receptor 1, Focal adhesion kinase 1/vascular endothelial growth factor receptor 3, Glycogen synthase kinase-3, Hepatocyte growth factor receptor, IKK epsilon/TBK1, Interleukin-1 receptor-associated kinase 1, Interleukin-1 receptor-associated kinase 3, JAK2/TYK2, Kinesin-1 heavy chain/ Tyrosine-protein kinase receptor RET, LIM domain kinase 1, LIM domain kinase 2, MAP kinase ERK2, MAP kinase p38, MAP kinase-activated protein kinase 3, MAP/microtubule affinity-regulating kinase 2, MAP/microtubule affinity-regulating kinase 4, Macrophage-stimulating protein receptor, Maternal embryonic leucine zipper kinase (MELK), Mitogen-activated protein kinase 14, Mitogen-activated protein kinase 2, Mitogen-activated protein kinase 3, Mitogen-activated protein kinase kinase kinase 1, Mitogen-activated protein kinase kinase kinase 11, Mitogen-activated protein kinase kinase kinase 2, Mitogen-activated protein kinase kinase kinase 3, Mitogen-activated protein kinase kinase kinase 4, Mitogen-activated protein kinase kinase kinase kinase 1, Mitogen-activated protein kinase kinase kinase kinase 3, Mitogen-activated protein kinase kinase kinase kinase 5, Mixed lineage kinase 7, Non-receptor tyrosine-protein kinase TNK1, PI3-kinase subunit alpha, PI3-kinase subunit beta, PI3-kinase subunit delta, PI3-kinase subunit gamma, PI4KA/PI4KAP2, PKC alpha and beta-2, PTK2B protein tyrosine kinase 2 beta (PTK2B), Phosphatidylinositol 3-kinase catalytic subunit type 3, Phosphatidylinositol 4-kinase beta (PIK4KB), Phosphatidylinositol-5-phosphate 4-kinase type-2 gamma, Phosphoinositide 3-kinase regulatory subunit 4, Phosphorylase kinase, Protein kinase C alpha type, Protein kinase C delta type, Protein kinase C theta type, Protein kinase N1, RAF serine/threonine protein kinase, Receptor-interacting serine/threonine-protein kinase 3, Ribosomal protein S6 kinase alpha 1, Ribosomal protein S6 kinase alpha 3, Ribosomal protein S6 kinase alpha 4, Ribosomal protein S6 kinase alpha 5, SRC, Salt-inducible kinase 2 (SIK2), Serine-protein kinase ATM, Serine/threonine protein kinase NLK, Serine/threonine-protein kinase 17B (STK17B), Serine/threonine-protein kinase 4 (STK4), Serine/threonine-protein kinase A-Raf, Serine/threonine-protein kinase ATR, Serine/threonine-protein kinase Aurora, Serine/threonine-protein kinase D2 (PKD2), Serine/threonine-protein kinase GAK, Serine/threonine-protein kinase ILK-1, Serine/threonine-protein kinase MST2, Serine/threonine-protein kinase NEK9, Serine/threonine-protein kinase Nek2, Serine/threonine-protein kinase PAK 4, Serine/threonine-protein kinase PLK4, Serine/threonine-protein kinase RIO2, Serine/threonine-protein kinase RIPK2, Serine/threonine-protein kinase SIK3, Serine/threonine-protein kinase TAO1, Serine/threonine-protein kinase TAO2, Serine/threonine-protein kinase TAO3, Serine/threonine-protein kinase ULK3, Serine/threonine-protein kinase WEE1, Serine/threonine-protein kinase mTOR, TGF-beta receptor type I, Tyrosine kinase non-receptor protein 2, Tyrosine- and threonine-specific cdc2-inhibitory kinase, Tyrosine-protein kinase ABL, Tyrosine-protein kinase ABL1, Tyrosine-protein kinase BRK, Tyrosine-protein kinase BTK, Tyrosine-protein kinase Blk, Tyrosine-protein kinase CSK, Tyrosine-protein kinase FER, Tyrosine-protein kinase Fes/Fps, Tyrosine-protein kinase ITK/TSK, Tyrosine-protein kinase JAK1, Tyrosine-protein kinase JAK2, Tyrosine-protein kinase STK16 (STK16), Tyrosine-protein kinase SYK, Tyrosine-protein kinase TEC, Tyrosine-protein kinase Yes, Uncharacterized aarF domain-containing protein kinase 4, VEGF-receptor 2 and tyrosine-protein kinase SRC, and c-Jun N-terminal kinase, JNK, Uniprot A0A024RDK3, O00329, O00444, O14965, O14976, O15197, O15530, O43353, O60674, O60885, O75582, O75676, O75716, O94768, O96013, P00519, P00533, P05771, P06239, P06241, P06493, P07332, P07947, P07948, P07949, P08581, P09769, P10398, P11362, P12931, P15056, P15735, P16591, P17252, P19784, P23458, P24941, P25440, P27037, P27361, P28482, P29317, P29320, P29323, P29597, P30291, P36507, P36894, P36896, P36897, P41240, P42336, P42338, P42345, P42680, P42684, P42685, P43405, P45983, P48729, P48730, P48736, P49674, P49759, P49760, P49840, P49841, P50613, P50750, P51451, P51617, P51812, P51955, P53667, P53671, P54646, P54760, P68400, Q00534, Q00535, Q02750, Q04759, Q04771, Q04912, Q05397, Q05655, Q06187, Q07912, Q08345, Q08881, Q12851, Q13043, Q13131, Q13163, Q13188, Q13233, Q13315, Q13418, Q13470, Q13535, Q13555, Q13557, Q13705, Q13882, Q14164, Q14289, Q14680, Q15059, Q15418, Q15569, Q15759, Q16512, Q16539, Q16566, Q16584, Q16644, Q2M2I8, Q541P7, Q6PHR2, Q7KZI7, Q7L7X3, Q8IU85, Q8IVH8, Q8N5S9, Q8NEB9, Q8NI60, Q8TBX8, Q8TD19, Q92918, Q96D53, Q96GD4, Q96L34, Q96RR4, Q96S53, Q99570, Q99640, Q99683, Q99759, Q9BQI3, Q9BVS4, Q9BZL6, Q9H0K1, Q9H2K8, Q9HCP0, Q9NSY1, Q9NYL2, Q9P2K8, Q9UBE8, Q9UBF8, Q9UHD2, Q9UL54, Q9Y2U5, Q9Y572, Q9Y616, Q9Y6M4, and Q9Y6R4