cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.24449464
title: Supplementary Material for: Transcrocetin meglumine salt inhibits spinal glial cell-mediated proinflammatory cytokines and attenuates complete Freund's adjuvant-induced inflammatory pain

description: Introduction: Inflammatory pain is a significant global clinical challenge that involves both unpleasant sensory and emotional experiences. The treatment of pain is imminent, and we are committed to seeking new analgesics for pain relief. Transcrocetin meglumine salt (TCMS), a saffron metabolite derived from the crocin apocarotenoids, has exhibited the ability to cross the blood-brain barrier and exert neuroprotective effects. In this study, we aimed to investigate whether TCMS could ameliorate complete Freund’s adjuvant (CFA)-induced inflammatory pain in mice and elucidate its underlying mechanisms. Methods: Here, we established an inflammatory pain model in mice by injecting CFA into the left hind paw. Three days later, we administered intraperitoneal injections of TCMS (10mg/kg) or saline to the animals. We examined mechanical allodynia, thermal hypersensitivity, and anxiety behavior. Furthermore, the activation of glial cells and proinflammatory cytokines in the spinal cord were detected. Results: Our results showed that TCMS significantly reversed the mechanical allodynia and thermal hypersensitivity in the CFA-injected mice. Furthermore, TCMS administration effectively inhibited the activation of microglia and astrocytes in the spinal cord induced by CFA. Additionally, TCMS suppressed the production and release of spinal proinflammatory cytokines, including TNF-α, IL-1β, and IL-6, in CFA-injected mice. Conclusion: Taken together, our findings demonstrate that TCMS holds promise as an innovative analgesic due to its ability to ameliorate inflammatory reactions.
DOI: 10.6084/m9.figshare.24449464.v1
title: Supplementary Material for: Transcrocetin meglumine salt inhibits spinal glial cell-mediated proinflammatory cytokines and attenuates complete Freund's adjuvant-induced inflammatory pain

description: Introduction: Inflammatory pain is a significant global clinical challenge that involves both unpleasant sensory and emotional experiences. The treatment of pain is imminent, and we are committed to seeking new analgesics for pain relief. Transcrocetin meglumine salt (TCMS), a saffron metabolite derived from the crocin apocarotenoids, has exhibited the ability to cross the blood-brain barrier and exert neuroprotective effects. In this study, we aimed to investigate whether TCMS could ameliorate complete Freund’s adjuvant (CFA)-induced inflammatory pain in mice and elucidate its underlying mechanisms. Methods: Here, we established an inflammatory pain model in mice by injecting CFA into the left hind paw. Three days later, we administered intraperitoneal injections of TCMS (10mg/kg) or saline to the animals. We examined mechanical allodynia, thermal hypersensitivity, and anxiety behavior. Furthermore, the activation of glial cells and proinflammatory cytokines in the spinal cord were detected. Results: Our results showed that TCMS significantly reversed the mechanical allodynia and thermal hypersensitivity in the CFA-injected mice. Furthermore, TCMS administration effectively inhibited the activation of microglia and astrocytes in the spinal cord induced by CFA. Additionally, TCMS suppressed the production and release of spinal proinflammatory cytokines, including TNF-α, IL-1β, and IL-6, in CFA-injected mice. Conclusion: Taken together, our findings demonstrate that TCMS holds promise as an innovative analgesic due to its ability to ameliorate inflammatory reactions.
DOI: 10.17630/3f2695c7-e6d5-4e11-a0b1-dcf1a54d4bb5
title: Fast Delayed Emission in New Pyridazine-based Compounds (dataset)
DOI: 10.5517/ccdc.csd.cc2b03l2
title: CCDC 2145063: Experimental Crystal Structure Determination

description: Related Article: Siqi Kong, Ran Liu, Zhiqiang Hao, Zhangang Han, Guo-Liang Lu, Jin Lin|2024|J.Mol.Struct.|1296|136870|doi:10.1016/j.molstruc.2023.136870
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2b04fy
title: CCDC 2145089: Experimental Crystal Structure Determination

description: Related Article: Siqi Kong, Ran Liu, Zhiqiang Hao, Zhangang Han, Guo-Liang Lu, Jin Lin|2024|J.Mol.Struct.|1296|136870|doi:10.1016/j.molstruc.2023.136870
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2b04h0
title: CCDC 2145091: Experimental Crystal Structure Determination

description: Related Article: Siqi Kong, Ran Liu, Zhiqiang Hao, Zhangang Han, Guo-Liang Lu, Jin Lin|2024|J.Mol.Struct.|1296|136870|doi:10.1016/j.molstruc.2023.136870
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.17630/880d0a9f-a205-4a42-825b-fbc87233090d
title: DATABASE OF DIFFERENTIAE VERBORUM
DOI: 10.6084/m9.figshare.24449473
title: Supplementary Material for: A novel c.3636-4 A&gt;G mutation in the CCDC88C plays a causative role in familial spinocerebellar ataxia

description: Introduction: Spinocerebellar ataxia (SCA) is an autosomal dominant genetic disease characterized by cerebellar neurological deficits. Specifically, its primary clinical manifestation is ataxia accompanied by peripheral nerve damage. A total of 48 causative genes of SCA have been identified. This study aimed to identify causative genes of autosomal dominant SCA in a four-generation Chinese kindred comprised of eight affected individuals. Methods: Genomic DNA samples were extracted from the pedigree members, and genomic whole-exome sequencing (WES) was performed, followed by bidirectional Sanger sequencing, and minigene assays to identify mutation sites. Results: A novel pathogenic heterozygous mutation in the splice region of the coiled-coil domain containing the 88C (CCDC88C) gene (NM_001080414:c.3636-4 A&gt;G) was identified in four affected members. The minigene assay results indicated that this mutation leads to the insertion of CAG bases (c.3636-1_3636-3 insCAG). Conclusion: CCDC88C gene mutation leads to SCA40 (OMIM:616053), which is a rare subtype of SCA without symptoms during childhood. Our findings further demonstrated the role of the CCDC88C gene in SCA and indicated that the c.3636-4 A&gt;G (NM_001080414) variant of CCDC88C is causative for a later-onset phenotype of SCA40. Our findings enrich the mutation spectrum of CCDC88C gene and provide a theoretical basis for the genetic counseling of SCA40.
DOI: 10.6084/m9.figshare.24449473.v1
title: Supplementary Material for: A novel c.3636-4 A&gt;G mutation in the CCDC88C plays a causative role in familial spinocerebellar ataxia

description: Introduction: Spinocerebellar ataxia (SCA) is an autosomal dominant genetic disease characterized by cerebellar neurological deficits. Specifically, its primary clinical manifestation is ataxia accompanied by peripheral nerve damage. A total of 48 causative genes of SCA have been identified. This study aimed to identify causative genes of autosomal dominant SCA in a four-generation Chinese kindred comprised of eight affected individuals. Methods: Genomic DNA samples were extracted from the pedigree members, and genomic whole-exome sequencing (WES) was performed, followed by bidirectional Sanger sequencing, and minigene assays to identify mutation sites. Results: A novel pathogenic heterozygous mutation in the splice region of the coiled-coil domain containing the 88C (CCDC88C) gene (NM_001080414:c.3636-4 A&gt;G) was identified in four affected members. The minigene assay results indicated that this mutation leads to the insertion of CAG bases (c.3636-1_3636-3 insCAG). Conclusion: CCDC88C gene mutation leads to SCA40 (OMIM:616053), which is a rare subtype of SCA without symptoms during childhood. Our findings further demonstrated the role of the CCDC88C gene in SCA and indicated that the c.3636-4 A&gt;G (NM_001080414) variant of CCDC88C is causative for a later-onset phenotype of SCA40. Our findings enrich the mutation spectrum of CCDC88C gene and provide a theoretical basis for the genetic counseling of SCA40.
DOI: 10.6084/m9.figshare.24249343
title: <b>Prediction Markets of Dosage Form Development</b><b> </b><b>for Incrementally Modified </b><b>Drugs </b><b>by Pharmaceutical Industry</b><b>in Thailand</b> (Prediction Market in Google Sheet)

description: The PM application was proceeded within Google Sheets, involving a total of four trading contract cycles, with eight available dosage forms: sustained release, delayed release, orodispersible tablet, nasal spray, chewable tablet, thin film, transdermal patch, and powder in a sachet. These dosage forms are derived from literature reviews and input from pharmaceutical industry experts and prescribers. To participate, investors can input the number of contracts or shares they intend to purchase for a specific drug form by locking the corresponding cell. The initial share or contract price is determined by an initial pricing formula, which will be adjusted based on market demand in subsequent rounds. The study comprises a total of four rounds, and investors are encouraged to invest until information becomes saturated.
DOI: 10.17630/058ba909-011e-4c5c-881d-271175acd8df
title: Palladium–catalysed methoxycarbonylation of ethene with bidentate diphosphine ligands: a density functional theory study (dataset)
DOI: 10.6084/m9.figshare.24566068
title: Supplementary Material for: Endoscopic treatment of colo-colonic intussusception in a patient with Peutz–Jeghers syndrome

description: A 19-year-old man with a history of Peutz–Jeghers syndrome (PJS) and two previous partial small bowel resections because of intussusception presented with lower abdominal pain. Computed tomography (CT) showed concentric multilayer and cord-like structures in the transverse colon. Colo-colonic intussusception was suspected and he was hospitalized. After two therapeutic enemas were unsuccessful, colonoscopy was performed. The intussusception was reduced and a 40 mm transverse colon polyp with a thick stalk was resected. After the procedure, his abdominal pain was relieved and he was discharged on the sixth hospital day. This case and several previous reports suggest that PJS polyps with tumor diameter exceeding 30 mm and location in the transverse or sigmoid colon can cause intussusception. Endoscopic treatment should be considered for these lesions.
DOI: 10.6084/m9.figshare.24459625
title: Supplementary Material for: Association of physical frailty and cognitive function in a population-based cross-sectional study of American older adults

description: Introduction: Cognitive impairment and frailty are prevalent in older persons. Physical frailty is associated with cognitive decline; however, the role of effect modifiers such as age, sex, race/ ethnicity, and cognitive reserve is not well understood. Methods: Cross-sectional data from the National Health and Nutrition Examination Survey (2011-2014) were obtained for participants aged ≥ 60 years. Complete availability of cognitive scores was an inclusion criterion. Physical frailty was defined by the presence of exhaustion, weakness, low body mass, and/or low physical activity, and categorized into three groups: robust (0 present), pre-frail (1–2 present), or frail (3–4 present). Four cognitive test scores were converted to z-scores, and global cognition (composite z-score) was calculated by averaging the four-individual z-scores. Multivariable linear regression models were fit to estimate the associations between frailty and cognitive function. Frailty was also evaluated as a risk factor for self-reported memory complaint (SMC) using logistic regression. All models were adjusted for age, sex, race/ethnicity, education, alcohol use, income, marital status, diabetes, hypertension, and history of stroke. Effect measure modification analyses were conducted by age, sex, race/ethnicity, education, and occupational cognitive demand. Results: The study population comprised 2,863 participants aged ≥ 60 years. Approximately half the participants were categorized into robust (50.6%), 43.2% pre-frail, and 6.2% frail. After adjusting for covariates, compared to robust participants, frail and prefrail participants had lower adjusted mean global cognitive z-scores, β ̂ = -0.61, 95% CI: -0.83, -0.38 and β ̂ = -0.21, 95% CI: -0.30, -0.12 respectively. Both prefrail and frail participants had higher odds of SMC compared to the robust participants. We did not see strong evidence that the association between frailty and cognition was modified by the factors we studied. Discussion/Conclusion: Both pre-frailty and frailty were associated with lower cognitive performance and were more likely to report subjective memory complaints relative to persons without frailty. These findings provide additional evidence that physical frailty may serve as a prognostic factor for cognitive deterioration or dementia, and prevention of frailty may be an important public health strategy.
DOI: 10.6084/m9.figshare.24459625.v1
title: Supplementary Material for: Association of physical frailty and cognitive function in a population-based cross-sectional study of American older adults

description: Introduction: Cognitive impairment and frailty are prevalent in older persons. Physical frailty is associated with cognitive decline; however, the role of effect modifiers such as age, sex, race/ ethnicity, and cognitive reserve is not well understood. Methods: Cross-sectional data from the National Health and Nutrition Examination Survey (2011-2014) were obtained for participants aged ≥ 60 years. Complete availability of cognitive scores was an inclusion criterion. Physical frailty was defined by the presence of exhaustion, weakness, low body mass, and/or low physical activity, and categorized into three groups: robust (0 present), pre-frail (1–2 present), or frail (3–4 present). Four cognitive test scores were converted to z-scores, and global cognition (composite z-score) was calculated by averaging the four-individual z-scores. Multivariable linear regression models were fit to estimate the associations between frailty and cognitive function. Frailty was also evaluated as a risk factor for self-reported memory complaint (SMC) using logistic regression. All models were adjusted for age, sex, race/ethnicity, education, alcohol use, income, marital status, diabetes, hypertension, and history of stroke. Effect measure modification analyses were conducted by age, sex, race/ethnicity, education, and occupational cognitive demand. Results: The study population comprised 2,863 participants aged ≥ 60 years. Approximately half the participants were categorized into robust (50.6%), 43.2% pre-frail, and 6.2% frail. After adjusting for covariates, compared to robust participants, frail and prefrail participants had lower adjusted mean global cognitive z-scores, β ̂ = -0.61, 95% CI: -0.83, -0.38 and β ̂ = -0.21, 95% CI: -0.30, -0.12 respectively. Both prefrail and frail participants had higher odds of SMC compared to the robust participants. We did not see strong evidence that the association between frailty and cognition was modified by the factors we studied. Discussion/Conclusion: Both pre-frailty and frailty were associated with lower cognitive performance and were more likely to report subjective memory complaints relative to persons without frailty. These findings provide additional evidence that physical frailty may serve as a prognostic factor for cognitive deterioration or dementia, and prevention of frailty may be an important public health strategy.
DOI: 10.5281/zenodo.10072000
title: Song Describer Dataset
title: a Corpus of Audio Captions for Music-and-Language Evaluation

description: The Song Describer Dataset: a Corpus of Audio Captions for Music-and-Language Evaluation

A retro-futurist drum machine groove drenched in bubbly synthetic sound effects and a hint of an acid bassline.
The Song Describer Dataset (SDD) contains ~1.1k captions for 706 permissively licensed music recordings. It is designed for use in evaluation of models that address music-and-language (M&L) tasks such as music captioning, text-to-music generation and music-language retrieval. More information about the data, collection method and validation is provided in the paper describing the dataset.
If you use this dataset, please cite our paper:
The Song Describer Dataset: a Corpus of Audio Captions for Music-and-Language Evaluation, Manco, Ilaria and Weck, Benno and Doh, Seungheon and Won, Minz and Zhang, Yixiao and Bogdanov, Dmitry and Wu, Yusong and Chen, Ke and Tovstogan, Philip and Benetos, Emmanouil and Quinton, Elio and Fazekas, György and Nam, Juhan, Machine Learning for Audio Workshop at NeurIPS 2023, 2023
DOI: 10.6084/m9.figshare.24433726
title: Supplementary Material for: FTO genotypes (rs9939609 T&gt;A) are associated with increased added sugar intake in healthy young adults

description: Introduction: Single-nucleotide polymorphism (SNP) rs9939609 in the FTO gene has been associated with dietary intake and appetite traits mainly in participants with obesity, however it remains widely unexplored in normal weight participants. Thus, the aims of this study were 1) to compare the changes in subjective appetite sensations, ghrelin, and insulin concentrations according to the SNP rs9939609 T&gt;A in FTO and 2) to compare dietary intake between rs9939609 genotype groups in normal weight young participants. Methods: We conducted a quasi-experimental study involving 88 normal-weight participants to analyze subjective perception of appetite, hormonal response for hunger and satiety, and dietary intake according to the rs9939609 SNP. Participants received a standardized single breakfast. Visual Analogue Scales (VAS) were utilized for assessing the subjective perception of appetite at fasting and immediately after breakfast and at 30, 60, 90, and 120 minutes postprandially. Glucose, lipid profile, ghrelin, and insulin were measured at fasting and at 120 minutes after breakfast. Dietary intake was assessed with a 3-day food record. The SNP was determined by allelic discrimination with TaqMan probes. To compare dietetic, biochemical, and the subjective appetite sensations, Student T test, ANCOVA test, and the repeated measures ANOVA were used. The linear regression model and the linear mixed model were used for the association analysis. Pearson correlation was used to test the correlation between two quantitative variables. Results: A total of 88 people participated, 81.8% were female, with a mean BMI of 21.8 ± 2.0 kg/m2 and a mean age of 20.6 ± 2.0. Genotype frequencies of the rs9939609 SNP were 52 % for the TT allele and 48 % for the TA/AA. The subjective perception of appetite named hunger, fullness, satiety, desire to eat, and prospective food consumption were similar between genotypes of the rs9939609. Participants with the TA/AA genotype showed a higher intake of added sugar (p=0.039) than TT participants. No differences were found in ghrelin, insulin, glucose, or lipid parameters between genotypes. Conclusion: Carriers of the A allele from FTO gene SNP rs9939609 may have an increased preference for foods, specifically for added sugars.
DOI: 10.5519/qd.yhmv5aas
title: Query on the Natural History Museum Data Portal (data.nhm.ac.uk) (10 records)
DOI: 10.34740/kaggle/dsv/6988893
title: 2021 World Population (updated daily)
DOI: 10.34740/kaggle/dsv/6988895
title: YouTube Trending Video Dataset (updated daily)
DOI: 10.5281/zenodo.10072001
title: Song Describer Dataset
title: a Corpus of Audio Captions for Music-and-Language Evaluation

description: The Song Describer Dataset: a Corpus of Audio Captions for Music-and-Language Evaluation

A retro-futurist drum machine groove drenched in bubbly synthetic sound effects and a hint of an acid bassline.
The Song Describer Dataset (SDD) contains ~1.1k captions for 706 permissively licensed music recordings. It is designed for use in evaluation of models that address music-and-language (M&L) tasks such as music captioning, text-to-music generation and music-language retrieval. More information about the data, collection method and validation is provided in the paper describing the dataset.
If you use this dataset, please cite our paper:
The Song Describer Dataset: a Corpus of Audio Captions for Music-and-Language Evaluation, Manco, Ilaria and Weck, Benno and Doh, Seungheon and Won, Minz and Zhang, Yixiao and Bogdanov, Dmitry and Wu, Yusong and Chen, Ke and Tovstogan, Philip and Benetos, Emmanouil and Quinton, Elio and Fazekas, György and Nam, Juhan, Machine Learning for Audio Workshop at NeurIPS 2023, 2023
DOI: 10.5281/zenodo.10149098
title: GRID used in ECCO version 4 release 5

description: There are slight differences in the land mask as compare with previous ECCO version 4 solutions (release 1,2,3,4; https://zenodo.org/doi/10.5281/zenodo.3966419)
DOI: 10.5281/zenodo.10149099
title: GRID used in ECCO version 4 release 5

description: There are slight differences in the land mask as compare with previous ECCO version 4 solutions (release 1,2,3,4; https://zenodo.org/doi/10.5281/zenodo.3966419)
DOI: 10.6084/m9.figshare.23715783.v2
title: Data source of the article "Estimates of persistent inward currents in lower limb muscles are not different between inactive, resistance-trained and endurance-trained young males"

description: The files contain all the data used to perform the analyses in the article "Estimates of persistent inward currents in lower limb muscles are not different between inactive, resistance-trained and endurance-trained young individuals", and th R code used for statistics analyses.
DOI: 10.17630/022e4feb-029c-4082-9518-a9da1ae3a937
title: Accurate efficiency measurements of organic light-emitting diodes via angle-resolved spectroscopy (dataset)

description: The accurate characterization of thin-film LEDs – including organic light emitting diodes (OLEDs), perovskites and quantum dot LEDs – is crucial to our understanding of the factors that influence their efficiency and thus to the fabrication of LEDs with improved performance and stability. In addition, detailed information about the angular characteristics of LED emission is useful to assess the suitability of individual architectures, e.g. for display applications. Here, the implementation of a goniometer-based measurement system and corresponding protocol are described that allow to accurately determine the current-voltage-luminance characteristics, external quantum efficiency and luminous efficacy of OLEDs and other emerging thin-film LEDs. The system allows recording of angle-resolved electroluminescence spectra and accurate efficiency measurements for devices with both Lambertian and non-Lambertian emission characteristics. A detailed description of the setup and a protocol for assembling and aligning the required hardware are provided. Drawings of all custom parts and the open-source Python software required to perform the measurement and to analyze the data are included.