cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.14169623.v2
title: Readily available biomarkers predict poor survival in metastatic pancreatic cancer

description: Identification of metastatic pancreatic cancer (mPC) patients with the worst prognosis could help to tailor therapy. We evaluated readily available biomarkers for the prediction of 90-day mortality in a nationwide cohort of mPC patients. Patients with synchronous mPC were included from the Netherlands Cancer Registry (2015–2017). Baseline CA19-9, albumin, CRP, LDH, CRP/albumin ratio, and (modified) Glasgow Prognostic Score ((m)GPS composed of albumin and CRP) were evaluated. Multivariable logistic regression analyses were performed to identify predictors of 90-day mortality. Prognostic value per predictor was quantified by Nagelkerke’s partial R<sup>2</sup>. Overall, 4248 patients were included. Median overall survival was 2.2 months and 90-day mortality was 59.4% (n = 1629). All biomarkers predicted 90-day mortality in univariable analysis, and remained statistically significant after adjustment for clinically relevant factors and all other biomarkers (all <i>p</i> In mPC patients, albumin, CA19-9, CRP, LDH, CRP/albumin ratio, and (m)GPS are prognostic for poor survival. Biomarkers did not predict response to chemotherapy. These readily available biomarkers can be used to better inform patients and to stratify in clinical trials.
DOI: 10.6084/m9.figshare.14134202
title: Impact of <i>MDM2</i> promoter SNP55 (rs2870820) on risk of endometrial and ovarian cancer

description: While large GWAS analyses have not found convincing associations between <i>MDM2</i> promoter SNP55 and gynaecological cancers, SNP55 is in linkage disequilibrium with two other functional SNPs in the same promoter, likely to obscure associations between single SNPs and cancer risk. Here, we assessed the impact of SNP55 on risk of endometrial and ovarian cancer, including sub-analyses stratified for other functional SNPs in the region. Using a custom LightSNiP assay, we genotyped SNP55 in two large hospital-based cohorts of patients with ovarian (n = 1,332) and endometrial (n = 1,363) cancer and compared genotypes to healthy female controls (n = 1,858). Among individuals harbouring the SNP309TT genotype, the minor SNP55T-allele was associated with a reduced risk of endometrial (dominant model: OR = 0.63; CI = 0.45–0.88; <i>p</i> = 0.01). Regardless of the genotype in neighbouring SNPs, the SNP55T-allele was also associated with a reduced risk of endometrial cancer before 50 years of age (dominant model: OR = 0.56; CI = 0.34–0.90; <i>p</i> = 0.02). No association between SNP55 status and ovarian cancer risk was observed. <i>MDM2</i> SNP55T-allele may correlate with reduced risk for endometrial cancer in a SNP309T-, but not SNP309G, context.
DOI: 10.6084/m9.figshare.13588642.v2
title: Comparison of clinical usefulness of serum Ca125 and CA19-9 in pancreatic adenocarcinoma diagnosis: meta-analysis and systematic review of literature

description: Pancreatic adenocarcinoma remains one of the most lethal cancers. The only recommended biomarker CA19-9 proves to be not accurate enough to establish a certain diagnosis. Therefore, a determination of usefulness of other biomarkers is essential. Our aim was to compare the specificity and sensitivity of Ca125 and CA19-9 by means of meta-analysis. The systematic review of combined tests (CA19-9 + Ca125) was also performed. We conducted a systematic search of Medline (via PubMed) and Ovid. After screening of abstracts and the assessment of full-texts, nine studies (number of patients, <i>n</i> = 1599) were included. Hierarchical summary receiver under operator curve (hsROC) model was applied to estimate the diagnostic accuracy. CA19-9 sensitivity and specificity were 0.748 (95%CI 0.676–0.809) and 0.782 (95%CI 0.716–0.836), respectively. These values were estimated on 0.593 (95%CI 0.489–0.69) and 0.754 (95%CI 0.817–0.668) for Ca125. Regarding the heterogeneity of studies, a strong threshold effect for Ca125 and moderate one for CA19-9 were found. Our meta-analysis did not prove the superiority of Ca125. It should be nevertheless noted that the sparsity of studies precludes accurate analysis of various factors’ influence. The review of proposed combined tests shows that CA19-9 + Ca125 models are generally characterized by higher sensitivity.
DOI: 10.6084/m9.figshare.14134202.v1
title: Impact of <i>MDM2</i> promoter SNP55 (rs2870820) on risk of endometrial and ovarian cancer

description: While large GWAS analyses have not found convincing associations between <i>MDM2</i> promoter SNP55 and gynaecological cancers, SNP55 is in linkage disequilibrium with two other functional SNPs in the same promoter, likely to obscure associations between single SNPs and cancer risk. Here, we assessed the impact of SNP55 on risk of endometrial and ovarian cancer, including sub-analyses stratified for other functional SNPs in the region. Using a custom LightSNiP assay, we genotyped SNP55 in two large hospital-based cohorts of patients with ovarian (n = 1,332) and endometrial (n = 1,363) cancer and compared genotypes to healthy female controls (n = 1,858). Among individuals harbouring the SNP309TT genotype, the minor SNP55T-allele was associated with a reduced risk of endometrial (dominant model: OR = 0.63; CI = 0.45–0.88; <i>p</i> = 0.01). Regardless of the genotype in neighbouring SNPs, the SNP55T-allele was also associated with a reduced risk of endometrial cancer before 50 years of age (dominant model: OR = 0.56; CI = 0.34–0.90; <i>p</i> = 0.02). No association between SNP55 status and ovarian cancer risk was observed. <i>MDM2</i> SNP55T-allele may correlate with reduced risk for endometrial cancer in a SNP309T-, but not SNP309G, context.
DOI: 10.6084/m9.figshare.14169623.v1
title: Readily available biomarkers predict poor survival in metastatic pancreatic cancer

description: <b><i>BACKGROUND:</i></b> Identification of metastatic pancreatic cancer (mPC) patients with worst prognosis could help to tailor therapy. We evaluated readily available biomarkers for the prediction of 90-day mortality in a nationwide cohort of mPC patients. <b><i>METHODS:</i></b> Patients with synchronous mPC were included from the Netherlands Cancer Registry (2015-2017). Baseline CA19-9, albumin, CRP, LDH, CRP/albumin ratio, and (modified) Glasgow Prognostic Score ((m)GPS composed of albumin and CRP) were evaluated. Multivariable logistic regression analyses were performed to identify predictors of 90-day mortality. Prognostic value per predictor was quantified by Nagelkerke’s partial R<sup>2</sup>. <b><i>RESULTS:</i></b> Overall, 4248 patients were included. Median overall survival was 2.2 months and 90-day mortality was 59.4% (n = 1629). All biomarkers predicted 90-day mortality in univariable analysis, and remained statistically significant after adjustment for clinically-relevant factors and all other biomarkers (all p <b><i>CONCLUSIONS:</i></b> In mPC patients, albumin, CA19-9, CRP, LDH, CRP/albumin ratio, and (m)GPS are prognostic for poor survival. Biomarkers did not predict response to chemotherapy. These readily available biomarkers can be used to better inform patients and to stratify in clinical trials.
DOI: 10.6084/m9.figshare.13588642
title: Comparison of clinical usefulness of serum Ca125 and CA19-9 in pancreatic adenocarcinoma diagnosis: meta-analysis and systematic review of literature

description: Pancreatic adenocarcinoma remains one of the most lethal cancers. The only recommended biomarker CA19-9 proves to be not accurate enough to establish a certain diagnosis. Therefore, a determination of usefulness of other biomarkers is essential. Our aim was to compare the specificity and sensitivity of Ca125 and CA19-9 by means of meta-analysis. The systematic review of combined tests (CA19-9 + Ca125) was also performed. We conducted a systematic search of Medline (via PubMed) and Ovid. After screening of abstracts and the assessment of full-texts, nine studies (number of patients, <i>n</i> = 1599) were included. Hierarchical summary receiver under operator curve (hsROC) model was applied to estimate the diagnostic accuracy. CA19-9 sensitivity and specificity were 0.748 (95%CI 0.676–0.809) and 0.782 (95%CI 0.716–0.836), respectively. These values were estimated on 0.593 (95%CI 0.489–0.69) and 0.754 (95%CI 0.817–0.668) for Ca125. Regarding the heterogeneity of studies, a strong threshold effect for Ca125 and moderate one for CA19-9 were found. Our meta-analysis did not prove the superiority of Ca125. It should be nevertheless noted that the sparsity of studies precludes accurate analysis of various factors’ influence. The review of proposed combined tests shows that CA19-9 + Ca125 models are generally characterized by higher sensitivity.
DOI: 10.5517/ccdc.csd.cc1khxcb
title: CCDC 1445262: Experimental Crystal Structure Determination

description: Related Article: Zhihao Lin, Ronghui Wu, Bin Chen, Shouwen Jin, Lingfeng Dong, Linqun Bai, Weiqiang Xu, Daqi Wang|2021|J.Mol.Struct.|1239|130510|doi:10.1016/j.molstruc.2021.130510
DOI: 10.5517/ccdc.csd.cc1kp24g
title: CCDC 1450215: Experimental Crystal Structure Determination

description: Related Article: Zhihao Lin, Ronghui Wu, Bin Chen, Shouwen Jin, Lingfeng Dong, Linqun Bai, Weiqiang Xu, Daqi Wang|2021|J.Mol.Struct.|1239|130510|doi:10.1016/j.molstruc.2021.130510
DOI: 10.5517/ccdc.csd.cc1kqdk7
title: CCDC 1451499: Experimental Crystal Structure Determination

description: Related Article: Zhihao Lin, Ronghui Wu, Bin Chen, Shouwen Jin, Lingfeng Dong, Linqun Bai, Weiqiang Xu, Daqi Wang|2021|J.Mol.Struct.|1239|130510|doi:10.1016/j.molstruc.2021.130510
DOI: 10.5517/ccdc.csd.cc1lm3lx
title: CCDC 1478129: Experimental Crystal Structure Determination

description: Related Article: Zhihao Lin, Ronghui Wu, Bin Chen, Shouwen Jin, Lingfeng Dong, Linqun Bai, Weiqiang Xu, Daqi Wang|2021|J.Mol.Struct.|1239|130510|doi:10.1016/j.molstruc.2021.130510
DOI: 10.5517/ccdc.csd.cc1kr7cx
title: CCDC 1452299: Experimental Crystal Structure Determination

description: Related Article: Zhihao Lin, Ronghui Wu, Bin Chen, Shouwen Jin, Lingfeng Dong, Linqun Bai, Weiqiang Xu, Daqi Wang|2021|J.Mol.Struct.|1239|130510|doi:10.1016/j.molstruc.2021.130510
DOI: 10.5517/ccdc.csd.cc1lm35h
title: CCDC 1478116: Experimental Crystal Structure Determination

description: Related Article: Zhihao Lin, Ronghui Wu, Bin Chen, Shouwen Jin, Lingfeng Dong, Linqun Bai, Weiqiang Xu, Daqi Wang|2021|J.Mol.Struct.|1239|130510|doi:10.1016/j.molstruc.2021.130510
DOI: 10.5517/ccdc.csd.cc1kkjf2
title: CCDC 1446814: Experimental Crystal Structure Determination

description: Related Article: Zhihao Lin, Ronghui Wu, Bin Chen, Shouwen Jin, Lingfeng Dong, Linqun Bai, Weiqiang Xu, Daqi Wang|2021|J.Mol.Struct.|1239|130510|doi:10.1016/j.molstruc.2021.130510
DOI: 10.5517/ccdc.csd.cc1knfd1
title: CCDC 1449603: Experimental Crystal Structure Determination

description: Related Article: Zhihao Lin, Ronghui Wu, Bin Chen, Shouwen Jin, Lingfeng Dong, Linqun Bai, Weiqiang Xu, Daqi Wang|2021|J.Mol.Struct.|1239|130510|doi:10.1016/j.molstruc.2021.130510
DOI: 10.5517/ccdc.csd.cc1mlq1z
title: CCDC 1507531: Experimental Crystal Structure Determination

description: Related Article: Zhihao Lin, Ronghui Wu, Bin Chen, Shouwen Jin, Lingfeng Dong, Linqun Bai, Weiqiang Xu, Daqi Wang|2021|J.Mol.Struct.|1239|130510|doi:10.1016/j.molstruc.2021.130510
DOI: 10.5517/ccdc.csd.cc25l4rp
title: CCDC 2013442: Experimental Crystal Structure Determination

description: Related Article: huan zhang|2020|CSD Communication|||
description: Related Article: Huan Zhang, Qi Wang, Lu Huang, Ziye Tian, Shunguang Zhang, Youlai Zhang|2021|Tetrahedron Lett.|72|153070|doi:10.1016/j.tetlet.2021.153070
DOI: 10.5517/ccdc.csd.cc25t236
title: CCDC 2020087: Experimental Crystal Structure Determination

description: Related Article: Eleftherios Halevas, Maria Arvanitidou, Barbara Mavroidi, Antonios G. Hatzidimitriou, Kostantinos Politopoulos, Eleni Alexandratou, Maria Pelecanou, Marina Sagnou|2021|J.Mol.Struct.|1240|130485|doi:10.1016/j.molstruc.2021.130485
DOI: 10.5517/ccdc.csd.cc27dd35
title: CCDC 2067486: Experimental Crystal Structure Determination

description: Related Article: Yunkai Shi, Chao Chen, Yaxi Yang, Bing zhou|2021|Tetrahedron Lett.|72|153065|doi:10.1016/j.tetlet.2021.153065
DOI: 10.14457/cu.the.1983.14
title: การเลี้ยงรา Rhizopus oryzae บนอาหารแข็งเพื่อผลิตกลูโคอมิเลส
DOI: 10.14457/cu.the.1983.15
title: Effect of capsaisin on the rate and contractile force of isolated rat atria
DOI: 10.15468/q32pea
title: The Winter Stoneflies (Plecoptera: Capniidae) Of Mississippi

description: This dataset contains the digitized treatments in Plazi based on the original journal article Nations, Tina M., Stark, Bill P., Hicks, Matthew B. (2007): The Winter Stoneflies (Plecoptera: Capniidae) Of Mississippi. Illiesia 3 (9): 70-94, DOI: http://doi.org/10.5281/zenodo.4759885
DOI: 10.15468/hmjqtp
title: The Larva And Egg Of Alloperla Prognoides (Plecoptera: Chloroperlidae), With Ecological Notes And New State Records From Florida, U. S. A.

description: This dataset contains the digitized treatments in Plazi based on the original journal article Ray, Donald H., Rasmussen, Andrew K., Peters, Janice G., Stark, Bill P. (2010): The Larva And Egg Of Alloperla Prognoides (Plecoptera: Chloroperlidae), With Ecological Notes And New State Records From Florida, U. S. A. Illiesia 6 (19): 256-266, DOI: http://doi.org/10.5281/zenodo.4760024
DOI: 10.5281/zenodo.4760049
title: Wave and tidally driven flows within a coral reef atoll off northwestern Australia

description: The dataset contains a combination of field observation and numerical modeling output files used to study the interaction between waves and tides on a coral reef atoll off the North West Shelf of Australia. Data included here is mostly raw and unprocessed. Please see the 'Metadata_Grimaldi_etal_JGR_Oceans.pdf' file or contact camille.grimaldi@research.uwa.edu.au for further information.
DOI: 10.6084/m9.figshare.14594847
title: Coding for Design Based Research in Mathematics Education

description: Papers about Mathematics Education using a Design Based Research methodology from 2012 to February 2021.
DOI: 10.3886/e140421
title: Replication files for "World War II and the Industrialization of the American South"

description: Replication files for "World War II and the Industrialization of the American South," published in the Journal of Economic History (2017).
DOI: 10.3886/e140421v1
title: Replication files for "World War II and the Industrialization of the American South"

description: Replication files for "World War II and the Industrialization of the American South," published in the Journal of Economic History (2017).
DOI: 10.5281/zenodo.4757174
title: Spawning gravel data for Pulg et al. 2019 Hydrobiologia

description: Trout fry and parr densities with river metadata corresponding to analysis in Pulg et al.
DOI: 10.5281/zenodo.4757173
title: Spawning gravel data for Pulg et al. 2019 Hydrobiologia

description: Trout fry and parr densities with river metadata corresponding to analysis in Pulg et al.
DOI: 10.5281/zenodo.4757176
title: PIT tagged fish from Dale River for Hulbak et al.

description: Salmon smolts were PIT tagged in Dale River in 2019 and recaptured at a wolf trap. There are multiple tagging groups at different times of the year to assess the impact of tag timing on growth, migration timing, and migration phenotype
DOI: 10.5281/zenodo.4757175
title: PIT tagged fish from Dale River for Hulbak et al.

description: Salmon smolts were PIT tagged in Dale River in 2019 and recaptured at a wolf trap. There are multiple tagging groups at different times of the year to assess the impact of tag timing on growth, migration timing, and migration phenotype
DOI: 10.5281/zenodo.4756316
title: The result data of Noah-MP-WDDMv1.42

description: The input and output data of "Improvement of stomatal resistance and photosynthesis mechanism of Noah-MP-WDDM (v1.42) in simulation of NO$_2$ dry deposition velocity in forests", which just submitted to Geoscientific Model Development as gmd-2021-157.
DOI: 10.5281/zenodo.4756315
title: The result data of Noah-MP-WDDMv1.42

description: The input and output data of "Improvement of stomatal resistance and photosynthesis mechanism of Noah-MP-WDDM (v1.42) in simulation of NO$_2$ dry deposition velocity in forests", which just submitted to Geoscientific Model Development as gmd-2021-157.
DOI: 10.5281/zenodo.4760495
title: Grayling catch-and-release data

description: Grayling reflex data from air exposure data from Lennox et al. (2016 Bor Env Res)
DOI: 10.5281/zenodo.4760494
title: Grayling catch-and-release data

description: Grayling reflex data from air exposure data from Lennox et al. (2016 Bor Env Res)
DOI: 10.5281/zenodo.4760509
title: Northern pike radio tag

description: Northern pike with embedded lures with radio tags tracking data, corresponding to data from Pullen et al.
DOI: 10.5281/zenodo.4760508
title: Northern pike radio tag

description: Northern pike with embedded lures with radio tags tracking data, corresponding to data from Pullen et al.
DOI: 10.5281/zenodo.4760507
title: Napoleon wrasse catch data from Anaa Atoll

description: Napoleon wrasse catches for length based assessment (SPR) corresponding to Lennox et al. 2019 (Endangered Species Research)
DOI: 10.5281/zenodo.4760506
title: Napoleon wrasse catch data from Anaa Atoll

description: Napoleon wrasse catches for length based assessment (SPR) corresponding to Lennox et al. 2019 (Endangered Species Research)
DOI: 10.5281/zenodo.4760493
title: Roundjaw bonefish catch and release data

description: Catch-and-release data from roundjaw bonefish in Anaa Atoll corresponding to Lennox et al. 2017 (N Am J Fish Manage)
DOI: 10.5281/zenodo.4760492
title: Roundjaw bonefish catch and release data

description: Catch-and-release data from roundjaw bonefish in Anaa Atoll corresponding to Lennox et al. 2017 (N Am J Fish Manage)
DOI: 10.5281/zenodo.4760595
title: Arapaima arapaima catch-and-release data from Rewa

description: Arapaima catches from Rewa, Guyana. Zipped file of accelerometer data files included (raw). Arapaima breaths after catch-and-release file included. Fish metadata.
DOI: 10.5281/zenodo.4760594
title: Arapaima arapaima catch-and-release data from Rewa

description: Arapaima catches from Rewa, Guyana. Zipped file of accelerometer data files included (raw). Arapaima breaths after catch-and-release file included. Fish metadata.
DOI: 10.6084/m9.figshare.14593911
title: Functional prediction of sponge microbiomes

description: Predicted sponge metagenomes (KO counts) through Tax4Fun2 and PICRUSt2
DOI: 10.6084/m9.figshare.14593911.v1
title: Functional prediction of sponge microbiomes

description: Predicted sponge metagenomes (KO counts) through Tax4Fun2 and PICRUSt2
DOI: 10.5281/zenodo.4760633
title: Atlantic salmon radio tag data from Gaula, 2013

description: Atlantic salmon were radio tagged after catch-and-release in Gaula, 2013. Fish metadata and radio tag position data included
DOI: 10.5281/zenodo.4760632
title: Atlantic salmon radio tag data from Gaula, 2013

description: Atlantic salmon were radio tagged after catch-and-release in Gaula, 2013. Fish metadata and radio tag position data included
DOI: 10.6084/m9.figshare.14587959.v1
title: Sponge microbiomes ASV table

description: Sponge bacterial communities under warming and acidification stress
DOI: 10.15151/esrf-es-447646593
title: Eco-friendly Alloys Designed for Additive Manufacturing

description: Laser Additive Manufacturing (LAM) is promoted as an eco-friendly process with very low waste. However, the yield in the powder manufacturing process is only as little as 30% for powder based LAM, thus it is critical to develop low impact feedstocks. This proposal will yield critical insights that are necessary to guide the development of LAM suitable metallic alloys that can obtained from recycled materials. Here, we propose to take advantage of ID11’s unique capability to map the 3D distribution of crystallographic phases and measure 3D stress states at high spatial resolution. This will be applied to a crystalline multi-phase grain network to generate microscale detail from prototype alloys. Specifically, data will enable failure prevention strategies based on impurities concentrations in the recycled materials.
DOI: 10.15151/esrf-es-440023009
title: Surface PDF

description: Study of GaAs surfaces
DOI: 10.6084/m9.figshare.14595417
title: 28s rRNA phylogenetic analysis

description: Confirmation of sponge identities through 28S rRNA gene phylogenetic analysis
DOI: 10.6084/m9.figshare.14595417.v1
title: 28s rRNA phylogenetic analysis

description: Confirmation of sponge identities through 28S rRNA gene phylogenetic analysis
DOI: 10.6084/m9.figshare.14595472.v1
title: Data files from Extreme lifespan extension in tapeworm-infected ant workers

description: Social insects are hosts of diverse parasites, but the influence of these parasites on phenotypic host traits is not yet well understood. Here, we tracked the survival of tapeworm-infected ant workers, their uninfected nest-mates and of ants from unparasitized colonies. Our multi-year study on the ant <i>Temnothorax nylanderi,</i> the intermediate host of the tapeworm <i>Anomotaenia brevis,</i> revealed a prolonged lifespan of infected workers compared to their uninfected peers. Intriguingly, their survival over 3 years did not differ from those of (uninfected) queens, whose lifespan can reach two decades. By contrast, uninfected workers from parasitized colonies suffered from increased mortality compared to uninfected workers from unparasitized colonies. Infected workers exhibited a metabolic rate and lipid content similar to young workers in this species, and they received more social care than uninfected workers and queens in their colonies. This increased attention could be mediated by their deviant chemical profile, which we determined to elicit more interest from uninfected nest-mates in a separate experiment. In conclusion, our study demonstrates an extreme lifespan extension in a social host following tapeworm infection, which appears to enable host workers to retain traits typical for young workers.
DOI: 10.6084/m9.figshare.14595472
title: Data files from Extreme lifespan extension in tapeworm-infected ant workers

description: Social insects are hosts of diverse parasites, but the influence of these parasites on phenotypic host traits is not yet well understood. Here, we tracked the survival of tapeworm-infected ant workers, their uninfected nest-mates and of ants from unparasitized colonies. Our multi-year study on the ant <i>Temnothorax nylanderi,</i> the intermediate host of the tapeworm <i>Anomotaenia brevis,</i> revealed a prolonged lifespan of infected workers compared to their uninfected peers. Intriguingly, their survival over 3 years did not differ from those of (uninfected) queens, whose lifespan can reach two decades. By contrast, uninfected workers from parasitized colonies suffered from increased mortality compared to uninfected workers from unparasitized colonies. Infected workers exhibited a metabolic rate and lipid content similar to young workers in this species, and they received more social care than uninfected workers and queens in their colonies. This increased attention could be mediated by their deviant chemical profile, which we determined to elicit more interest from uninfected nest-mates in a separate experiment. In conclusion, our study demonstrates an extreme lifespan extension in a social host following tapeworm infection, which appears to enable host workers to retain traits typical for young workers.
DOI: 10.5517/ccdc.csd.cc2245m1
title: CCDC 1910642: Experimental Crystal Structure Determination

description: Related Article: Yan Yang, Lianzhi Li, Hua Yang, Lei Sun|2021|Cryst.Growth Des.|21|2954|doi:10.1021/acs.cgd.1c00116
DOI: 10.5517/ccdc.csd.cc2245n2
title: CCDC 1910643: Experimental Crystal Structure Determination

description: Related Article: Yan Yang, Lianzhi Li, Hua Yang, Lei Sun|2021|Cryst.Growth Des.|21|2954|doi:10.1021/acs.cgd.1c00116