cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.11869245.v1
title: The Scale for Evaluating Eating Behaviour in Autism Spectrum Disorder: validation study

description: ABSTRACT Objective An evaluation instrument was developed to assess the eating behavior of individuals with autism spectrum disorder (ASD), both from the professional viewpoint and based on aspects identified as problematic by parents at semi-structured interviews. Methods A multidisciplinary team analyzed content validity. The scale was applied verbally and individually to parents of individuals with ASD for semantic adjustment. Overall, 298 individuals answered this preliminary version of the scale, with varimax rotation being used to analyze the principal components. Results Of the 53 items initially developed to assess the construct, 33 proved valid for evaluation of the attribute and three were added, thus obtaining the second version of the scale, which was then answered by 130 individuals. Of the 35 items that remained after the first factor analysis, 26 proved valid for evaluation of the attribute and were divided into seven domains: the motricity of chewing, food selectivity, mealtime skills, inappropriate mealtime behavior, inflexible eating-related behavior, hostility towards food, and food allergies and intolerance. The final structure of the scale was composed of 26 items, distributed in seven factors, presenting an overall reliability value of 0.867. Conclusion The scale aims to identify the areas of eating behavior that are altered in individuals with ASD, allowing more specific therapy to be implemented. The tool could also be used to measure the effectiveness of treatment.
DOI: 10.6084/m9.figshare.11869248.v1
title: Spinal protein kinase A and phosphorylated extracellular signal-regulated kinase signaling are involved in the antinociceptive effect of phytohormone abscisic acid in rats

description: Abstract Objective: The phytohormone abscisic acid (ABA) as a signaling molecule exists in various types of organisms from early multicellular to animal cells and tissues. It has been demonstrated that ABA has an antinociceptive effect in rodents. The present study was designed to assess the possible role of PKA and phosphorylated ERK (p-ERK) on the antinociceptive effects of intrathecal (i.t.) ABA in male Wistar rats. Methods: The animals were cannulated intrathecally and divided into different experimental groups (n=6‒7): Control (no surgery), vehicle (received ABA vehicle), ABA-treated groups (received ABA in doses of 10 or 20 µg/rat), ABA plus H.89 (PKA inhibitor)-treated group which received the inhibitor 15 min prior to the ABA injection. Tail-flick and hot-plate tests were used as acute nociceptive stimulators to assess ABA analgesic effects. p-ERK was evaluated in the dorsal portion of the spinal cord using immunoblotting. Results: Data showed that a microinjection of ABA (10 and 20 µg/rat, i.t.) significantly increased the nociceptive threshold in tail flick and hot plate tests. The application of PKA inhibitor (H.89, 100 nM/rat) significantly inhibited ABA-induced analgesic effects. Expression of p-ERK was significantly decreased in ABA-injected animals, which were not observed in the ABA+H.89-treated group. Conclusions: Overall, i.t. administration of ABA (10 µg/rat) induced analgesia and p-ERK down-expression likely by involving the PKA-dependent mechanism.
DOI: 10.6084/m9.figshare.11869242
title: Growth indexes of Pennisetum purpureum cv. Roxo cultivated in different seasons under rainfed conditions

description: ABSTRACT The objective was to estimate the growth indexes of elephant grass cv. Roxo managed under rainfed conditions in different growing seasons. Seven growth ages (9, 18, 27, 36, 45, 54, and 63 days) were evaluated in three growing seasons (rainy, transition and dry). A completely randomised design was adopted, with split-plot arrangement with time repeated measures, with the ages being the plots and the seasons the subplots. Interaction of age x season was observed. The specific leaf area mean was 0.0286 ± 0.0039 during the rainy season. In the transition season, it adjusted to a third-degree polynomial model; in the dry season it declined linearly (0.0003 m2 g-1). The leaf weight ratio adjusted to the third-degree polynomial model in the rainy and dry seasons, and in the transition season it was maximised at 28 DAC (0.694 g g-1). The leaf area ratio continuously declined in the rainy season. In the transition and dry seasons, it adjusted to the third-degree polynomial model. The net assimilation rate presented averages of 3.73 ± 2.50 and 3.63 ± 1.48 g m-2 day-1 in the rainy and transition seasons, respectively. In the dry season, it was minimised at 48.4 days. The relative growth rate mean was 0.0075 ± 0.0037 during the rainy season. In the transition and dry seasons, it adjusted to the third-degree polynomial model. The growth index rates of elephant grass cv. Roxo are modified by growing seasons, and the pattern and magnitude of the response varies throughout the growth cycle.
DOI: 10.6084/m9.figshare.11869242.v1
title: Growth indexes of Pennisetum purpureum cv. Roxo cultivated in different seasons under rainfed conditions

description: ABSTRACT The objective was to estimate the growth indexes of elephant grass cv. Roxo managed under rainfed conditions in different growing seasons. Seven growth ages (9, 18, 27, 36, 45, 54, and 63 days) were evaluated in three growing seasons (rainy, transition and dry). A completely randomised design was adopted, with split-plot arrangement with time repeated measures, with the ages being the plots and the seasons the subplots. Interaction of age x season was observed. The specific leaf area mean was 0.0286 ± 0.0039 during the rainy season. In the transition season, it adjusted to a third-degree polynomial model; in the dry season it declined linearly (0.0003 m2 g-1). The leaf weight ratio adjusted to the third-degree polynomial model in the rainy and dry seasons, and in the transition season it was maximised at 28 DAC (0.694 g g-1). The leaf area ratio continuously declined in the rainy season. In the transition and dry seasons, it adjusted to the third-degree polynomial model. The net assimilation rate presented averages of 3.73 ± 2.50 and 3.63 ± 1.48 g m-2 day-1 in the rainy and transition seasons, respectively. In the dry season, it was minimised at 48.4 days. The relative growth rate mean was 0.0075 ± 0.0037 during the rainy season. In the transition and dry seasons, it adjusted to the third-degree polynomial model. The growth index rates of elephant grass cv. Roxo are modified by growing seasons, and the pattern and magnitude of the response varies throughout the growth cycle.
DOI: 10.6084/m9.figshare.11869233
title: Impaired Right Ventricular Function in Heart Transplant Rejection

description: Abstract Background: The practice of screening for complications has provided high survival rates among heart transplantation (HTx) recipients. Objectives: Our aim was to assess whether changes in left ventricular (LV) and right ventricular (RV) global longitudinal strain (GLS) are associated with cellular rejection. Methods: Patients who underwent HTx in a single center (2015 - 2016; n = 19) were included in this retrospective analysis. A total of 170 biopsies and corresponding echocardiograms were evaluated. Comparisons were made among biopsy/echocardiogram pairs with no or mild (0R/1R) evidence of cellular rejection (n = 130 and n = 25, respectively) and those with moderate (2R) rejection episodes (n=15). P-values &lt; 0.05 were considered statistically significant Results: Most patients were women (58%) with 48 ± 12.4 years of age. Compared with echocardiograms from patients with 0R/1R rejection, those of patients with 2R biopsies showed greater LV posterior wall thickness, E/e’ ratio, and E/A ratio compared to the other group. LV systolic function did not differ between groups. On the other hand, RV systolic function was more reduced in the 2R group than in the other group, when evaluated by TAPSE, S wave, and RV fractional area change (all p &lt; 0.05). Furthermore, RV GLS (−23.0 ± 4.4% in the 0R/1R group vs. −20.6 ± 4.9% in the 2R group, p = 0.038) was more reduced in the 2R group than in the 0R/1R group. Conclusion: In HTx recipients, moderate acute cellular rejection is associated with RV systolic dysfunction as evaluated by RV strain, as well as by conventional echocardiographic parameters. Several echocardiographic parameters may be used to screen for cellular rejection.
DOI: 10.6084/m9.figshare.11869233.v1
title: Impaired Right Ventricular Function in Heart Transplant Rejection

description: Abstract Background: The practice of screening for complications has provided high survival rates among heart transplantation (HTx) recipients. Objectives: Our aim was to assess whether changes in left ventricular (LV) and right ventricular (RV) global longitudinal strain (GLS) are associated with cellular rejection. Methods: Patients who underwent HTx in a single center (2015 - 2016; n = 19) were included in this retrospective analysis. A total of 170 biopsies and corresponding echocardiograms were evaluated. Comparisons were made among biopsy/echocardiogram pairs with no or mild (0R/1R) evidence of cellular rejection (n = 130 and n = 25, respectively) and those with moderate (2R) rejection episodes (n=15). P-values &lt; 0.05 were considered statistically significant Results: Most patients were women (58%) with 48 ± 12.4 years of age. Compared with echocardiograms from patients with 0R/1R rejection, those of patients with 2R biopsies showed greater LV posterior wall thickness, E/e’ ratio, and E/A ratio compared to the other group. LV systolic function did not differ between groups. On the other hand, RV systolic function was more reduced in the 2R group than in the other group, when evaluated by TAPSE, S wave, and RV fractional area change (all p &lt; 0.05). Furthermore, RV GLS (−23.0 ± 4.4% in the 0R/1R group vs. −20.6 ± 4.9% in the 2R group, p = 0.038) was more reduced in the 2R group than in the 0R/1R group. Conclusion: In HTx recipients, moderate acute cellular rejection is associated with RV systolic dysfunction as evaluated by RV strain, as well as by conventional echocardiographic parameters. Several echocardiographic parameters may be used to screen for cellular rejection.
DOI: 10.6084/m9.figshare.11869224
title: Therapeutic effect of adenosine on experimentally induced acute ulcerative colitis model in rats

description: Abstract Purpose To examine the therapeutic effect of external adenosine on an acetic acid-induced acute ulcerative colitis model in rats. Methods Thirty male mature rats were divided into three groups as control, acute colitis (AC) and AC+adenosine group (AC+AD). AC was induced by rectal administration of 4% acetic acid (AA). 5mg/kg/day adenosine was performed i.p for 4 weeks to AC+AD group. Rectum and colon were excised for microscopic and histopathological histopathologic evaluations, and immunohistochemical analysis of nuclear factor kappa B (NF-kB). Blood samples were collected for biochemical detection of TNF-α, Pentraxin-3 and malondialdehyde (MDA) levels. Results AC group had generalized hyperemia and hemorrhage with increased macroscopic and histopathological scores compared with control (P &lt;0.0001) while adenosine treatment decreased these scores significantly (P &lt;0.001), with reduced distribution of disrupted epithelium, leukocyte infiltrates, and focal hemorrhage. AC group showed significantly increased immunoexpression of NF-kB in rectum, plasma and tissue levels of TNF-α, plasma Pentraxin-3 and MDA levels (P &lt;0.0001) while adenosine reduced these levels (P &lt; 0.05). Conclusion Adenosine appears to promote healing of colon and rectum exposed to AA-induced AC, suggesting a boosting effect of adenosine on the intestinal immune system to cure ulcerative colitis.
DOI: 10.6084/m9.figshare.11869224.v1
title: Therapeutic effect of adenosine on experimentally induced acute ulcerative colitis model in rats

description: Abstract Purpose To examine the therapeutic effect of external adenosine on an acetic acid-induced acute ulcerative colitis model in rats. Methods Thirty male mature rats were divided into three groups as control, acute colitis (AC) and AC+adenosine group (AC+AD). AC was induced by rectal administration of 4% acetic acid (AA). 5mg/kg/day adenosine was performed i.p for 4 weeks to AC+AD group. Rectum and colon were excised for microscopic and histopathological histopathologic evaluations, and immunohistochemical analysis of nuclear factor kappa B (NF-kB). Blood samples were collected for biochemical detection of TNF-α, Pentraxin-3 and malondialdehyde (MDA) levels. Results AC group had generalized hyperemia and hemorrhage with increased macroscopic and histopathological scores compared with control (P &lt;0.0001) while adenosine treatment decreased these scores significantly (P &lt;0.001), with reduced distribution of disrupted epithelium, leukocyte infiltrates, and focal hemorrhage. AC group showed significantly increased immunoexpression of NF-kB in rectum, plasma and tissue levels of TNF-α, plasma Pentraxin-3 and MDA levels (P &lt;0.0001) while adenosine reduced these levels (P &lt; 0.05). Conclusion Adenosine appears to promote healing of colon and rectum exposed to AA-induced AC, suggesting a boosting effect of adenosine on the intestinal immune system to cure ulcerative colitis.
DOI: 10.6084/m9.figshare.11869227
title: Analysis of &gt;100,000 Cardiovascular Surgeries Performed at the Heart Institute and a New Era of Outcomes

description: Abstract Background: The current challenge of cardiovascular surgery (CVS) is to improve the outcomes in increasingly severe patients. In this respect, continuous quality improvement (CQI) programs have had an impact on outcomes. Objective: To assess the evolution of the incidence and mortality due to CVS, as well as the current outcomes of the Hospital das Clínicas Heart Institute of the University of São Paulo Medical School (InCor-HCFMUSP). Methods: An outcome analysis of CVSs performed at the InCor, between January 1984 and June 2019. We observed the surgical volume and mortality rates in 5 time periods: 1st (1984-1989), 2nd (1990-1999), 3rd (2000-2007), 4th (2008-2015) and 5th (2016-2019). The CQI program was implemented between 2015 and 2016. The analysis included the total number of surgeries and the evolution of the most frequent procedures. Results: A total of 105,599 CCVs were performed, with an annual mean of 2,964 procedures and mortality of 5,63%. When comparing the 4th and the 5th periods, the average global volume of surgeries was increased from 2,943 to 3,139 (p = 0.368), bypass graft (CABG), from 638 to 597 (p = 0.214), heart valve surgery, from 372 to 465 (p = 0.201), and congenital heart disease surgery, from 530 to 615 (p = 0.125). The average global mortality went from 7.8% to 5% (p &lt; 0.0001); in CABG surgery, from 5.8% to 3.1% (p &lt; 0.0001); in heart valve surgery, from 14% to 7.5% (p &lt; 0.0001) and in congenital heart disease surgery, from 12.1% to 9.6% (p &lt; 0.0001). Conclusion: In spite of a recent trend towards increased surgical volume, there was a significant decrease in operative mortality in the groups studied. After the implementation of the CQI program, the mortality rates were closer to international standards.
DOI: 10.6084/m9.figshare.11869221
title: CAN BASAL CUTTING BLADE WEAR AFFECT SUGARCANE REGROWTH?

description: ABSTRACT Sugarcane harvester cutting blade wear increases ratoon damages and losses, impairing sugarcane regrowth. This study aimed to evaluate the quality of basal cut using ratoon damage and loss indexes and correlating them with effects on sugarcane regrowth. Harvest parameters such as plant height and position, damage and loss indexes, and stem length were evaluated every 30 min, following statistical process control (SPC) assumptions. Blade wear was examined during three harvesting shifts (0-8 h, 8-16 h, and 16-24 h). Sugarcane regrowth was assessed by counting number of tillers and measuring plant height and stem diameter. The second harvesting shift showed better quality in terms of damage and loss indexes, and plant height and stem diameter. Harvesting was considered out of control for parameters such as cutting height, number of tillers, plant height, and stem diameter. On the other side, it was regarded as under control for damage and loss indexes, and plant high and position. The first shift presented peripheral or no damages and weak to medium loss levels, whereas the second and third ones showed extreme damages and medium to strong losses.
DOI: 10.6084/m9.figshare.11869227.v1
title: Analysis of &gt;100,000 Cardiovascular Surgeries Performed at the Heart Institute and a New Era of Outcomes

description: Abstract Background: The current challenge of cardiovascular surgery (CVS) is to improve the outcomes in increasingly severe patients. In this respect, continuous quality improvement (CQI) programs have had an impact on outcomes. Objective: To assess the evolution of the incidence and mortality due to CVS, as well as the current outcomes of the Hospital das Clínicas Heart Institute of the University of São Paulo Medical School (InCor-HCFMUSP). Methods: An outcome analysis of CVSs performed at the InCor, between January 1984 and June 2019. We observed the surgical volume and mortality rates in 5 time periods: 1st (1984-1989), 2nd (1990-1999), 3rd (2000-2007), 4th (2008-2015) and 5th (2016-2019). The CQI program was implemented between 2015 and 2016. The analysis included the total number of surgeries and the evolution of the most frequent procedures. Results: A total of 105,599 CCVs were performed, with an annual mean of 2,964 procedures and mortality of 5,63%. When comparing the 4th and the 5th periods, the average global volume of surgeries was increased from 2,943 to 3,139 (p = 0.368), bypass graft (CABG), from 638 to 597 (p = 0.214), heart valve surgery, from 372 to 465 (p = 0.201), and congenital heart disease surgery, from 530 to 615 (p = 0.125). The average global mortality went from 7.8% to 5% (p &lt; 0.0001); in CABG surgery, from 5.8% to 3.1% (p &lt; 0.0001); in heart valve surgery, from 14% to 7.5% (p &lt; 0.0001) and in congenital heart disease surgery, from 12.1% to 9.6% (p &lt; 0.0001). Conclusion: In spite of a recent trend towards increased surgical volume, there was a significant decrease in operative mortality in the groups studied. After the implementation of the CQI program, the mortality rates were closer to international standards.
DOI: 10.6084/m9.figshare.11869215
title: Extent of Left Atrial Ablation Lesions and Atrial Fibrillation Recurrence after Catheter Ablation - A Systematic Review and Meta-Analysis

description: Abstract Background: Atrial fibrillation (AF) is known to induce atrial remodeling, which promotes fibrosis related to arrhythmogenesis. Accordingly, since scars induced by catheter ablation (CA) can reduce unablated fibrotic areas, greater extent of left atrial (LA) scarring may be associated with less AF recurrence after CA. Objectives: This study aims to investigate, through systematic review and meta-analysis, whether the amount of LA scarring, seen on late gadolinium enhancement magnetic resonance imaging, is associated with less AF recurrence after CA. Methods: The recommendations of the MOOSE guideline were followed. Database search was conducted in PubMed and Cochrane Central Register of Controlled Trials (comentário 1) until January 2019 (comentário 2). Two authors performed screening, data extraction, and quality evaluation. All studies were graded as good quality. A funnel plot was generated, showing no publication bias. Statistical significance was defined as p value &lt; 0.05. Results: Eight observational studies were included in the systematic review, four of which were included in the meta-analysis. Six of the eight studies included in the systematic review showed that greater extension of LA scarring is associated with less AF recurrence after CA. Meta-analysis showed that greater extension of LA scarring is associated with less AF recurrence (SMD = 0.52; 95% CI 0.27 - 0.76; p &lt; 0.0001). Conclusion: Greater extension of LA scarring is possibly associated with less AF recurrence after CA. Randomized studies that explore ablation methods based on this association are fundamental.
DOI: 10.6084/m9.figshare.11869218
title: TIN: A STRATEGIC METAL YESTERDAY AND TODAY

description: Tin chemistry sometimes is considered boring, colourless and with irrelevant applications. Archaeological, historical and technological facts show otherwise. These facts demonstrate that tin became vital for man in a distant past and its importance lasts thereafter. In this paper, it is introduced some historical arguments that reveal the significance of tin or cassiterite as strategic materials in ancient tools, beginning from the Bronze Age. This paper shows as well the importance of this metal in current times. It also describes the importance of Brazil in this scenario, given the large reserves of cassiterite and its crucial participation in the world market. In addition, it provides a revision of the main classes of tin compounds {Sn (IV) and Sn (II), among other oxidation states}. Additionally, it summarises some main applications of tin compounds, such as PVC stabilizers, antifouling paint and in the manufacturing of foams and polymers, discussing its strategic role in modern technologies. Finally, it highlights the importance of tin in the preparation of Nb3Sn, a superconducting alloy with niobium, and in the synthesis of new materials, for example, a two-dimensional polymer, structurally similar to graphene.
DOI: 10.6084/m9.figshare.11869215.v1
title: Extent of Left Atrial Ablation Lesions and Atrial Fibrillation Recurrence after Catheter Ablation - A Systematic Review and Meta-Analysis

description: Abstract Background: Atrial fibrillation (AF) is known to induce atrial remodeling, which promotes fibrosis related to arrhythmogenesis. Accordingly, since scars induced by catheter ablation (CA) can reduce unablated fibrotic areas, greater extent of left atrial (LA) scarring may be associated with less AF recurrence after CA. Objectives: This study aims to investigate, through systematic review and meta-analysis, whether the amount of LA scarring, seen on late gadolinium enhancement magnetic resonance imaging, is associated with less AF recurrence after CA. Methods: The recommendations of the MOOSE guideline were followed. Database search was conducted in PubMed and Cochrane Central Register of Controlled Trials (comentário 1) until January 2019 (comentário 2). Two authors performed screening, data extraction, and quality evaluation. All studies were graded as good quality. A funnel plot was generated, showing no publication bias. Statistical significance was defined as p value &lt; 0.05. Results: Eight observational studies were included in the systematic review, four of which were included in the meta-analysis. Six of the eight studies included in the systematic review showed that greater extension of LA scarring is associated with less AF recurrence after CA. Meta-analysis showed that greater extension of LA scarring is associated with less AF recurrence (SMD = 0.52; 95% CI 0.27 - 0.76; p &lt; 0.0001). Conclusion: Greater extension of LA scarring is possibly associated with less AF recurrence after CA. Randomized studies that explore ablation methods based on this association are fundamental.