cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.23566587
title: Supplementary Material for: Association between Physical Activity and Sitting Time Related to Excess Body Weight in Brazilian University Students

description: High exposure to sedentary behavior and lower levels of physical activity can lead to excess body weight (EBW). The aim of this study was to estimate the prevalence of EBW and the direct association under the condition of sociodemographic, university, and behavioral moderating characteristics, between physical activity and sitting time related to EBW in Brazilian university students. A cross-sectional study was carried out with 1,110 university students from a federal public institution in Minas Gerais, Brazil. The outcome was the EBW (body mass index: ≥25.0 kg/m<sup>2</sup>) and the independent variables were physical activity (insufficiently active and active) and sitting time (&lt;6 h/day; ≥6 h/day). Association analyses were estimated via odds ratio (OR) using binary logistic regression. The significance level was 5%. The prevalence of EBW was 27.8%. No direct association was observed between physical activity and time sitting related to EBW. However, insufficiently active university students were more likely to have EBW (OR = 1.91; 95% CI: 1.06–3.47) when they did not consume alcoholic beverages, and university students with a sitting time of ≥6 h/day had lower chances of having EBW (OR = 0.62; 95% CI: 0.40–0.95) when they had spent more time at university (3 years or more). It is concluded that the prevalence of EBW in university students was high and there was no direct association between physical activity and sitting time; however, alcohol consumption and university time moderated the association with higher and lower chances of occurrence of EBW in university students, respectively.
DOI: 10.6084/m9.figshare.23545677
title: Supplementary Material for: Multiple Dermatomyofibromas in a Patient with Ehlers-Danlos Syndrome

description: Dermatomyofibromas are a rare, benign, acquired neoplasm with less than 150 reported cases worldwide. The etiologic factors that contribute to the development of these lesions are currently unknown. To our knowledge, there have been only six previously reported cases of patients presenting with multiple dermatomyofibromas, and in each of these cases, there were less than ten lesions present. Herein, we describe a patient who developed more than 100 dermatomyofibromas over a period of years, and we argue that the patient’s concurrent Ehlers-Danlos syndrome could have contributed to this unique presentation by inducing an increased fibroblast-to-myofibroblast transition.
DOI: 10.6084/m9.figshare.23545677.v1
title: Supplementary Material for: Multiple Dermatomyofibromas in a Patient with Ehlers-Danlos Syndrome

description: Dermatomyofibromas are a rare, benign, acquired neoplasm with less than 150 reported cases worldwide. The etiologic factors that contribute to the development of these lesions are currently unknown. To our knowledge, there have been only six previously reported cases of patients presenting with multiple dermatomyofibromas, and in each of these cases, there were less than ten lesions present. Herein, we describe a patient who developed more than 100 dermatomyofibromas over a period of years, and we argue that the patient’s concurrent Ehlers-Danlos syndrome could have contributed to this unique presentation by inducing an increased fibroblast-to-myofibroblast transition.
DOI: 10.5517/ccdc.csd.cc2fnsyv
title: CCDC 2254318: Experimental Crystal Structure Determination

description: Related Article: Mamta Gill, Vinod K. Singh|2023|Tetrahedron Lett.|123|154555|doi:10.1016/j.tetlet.2023.154555
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2fnszw
title: CCDC 2254319: Experimental Crystal Structure Determination

description: Related Article: Mamta Gill, Vinod K. Singh|2023|Tetrahedron Lett.|123|154555|doi:10.1016/j.tetlet.2023.154555
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5281/zenodo.8082840
title: chondracanthus_exasperatus_decontaminated_gx.fasta

description: .
DOI: 10.5281/zenodo.8082839
title: chondracanthus_exasperatus_decontaminated_gx.fasta

description: .
DOI: 10.6084/m9.figshare.23295740
title: Supplementary Material for: Detection of Modified Histones from Oral Mucosa of a Patient with DYT-<i>KMT2B</i> Dystonia

description: <b><i>Introduction:</i></b> DYT-<i>KMT2B</i> is a rare childhood-onset, hereditary movement disorder typically characterized by lower-limb dystonia and subsequently spreads into the craniocervical and laryngeal muscles. Recently, <i>KMT2B</i>-encoding lysine (K)-specific histone methyltransferase 2B was identified as the causative gene for DYT-<i>KMT2B</i>, also known as DYT28. In addition to the fact that many physicians do not have sufficient experience or knowledge of hereditary dystonia, the clinical features of DYT-<i>KMT2B</i> overlap with those of other hereditary dystonia, and limited clinical biomarkers make the diagnosis difficult. <b><i>Methods:</i></b> Histone proteins were purified from the oral mucosa of patients with de novo <i>KMT2B</i> mutation causing premature stop codon, and then trimethylated fourth lysine residue of histone H3 (H3K4me3) which was catalyzed by KMT2B was analyzed by immunoblotting with specific antibody. We further analyzed the significance of H3K4me3 in patients with DYT-<i>KMT2B</i> using publicly available datasets. <b><i>Results:</i></b> H3K4me3 histone mark was markedly lower in the patient than in the control group. Additionally, a reanalysis of publicly available datasets concerning DNA methylation also demonstrated that <i>KMT2B</i> remained inactive in DYT-<i>KMT2B</i>. <b><i>Discussion:</i></b> Although only one case was studied due to the rarity of the disease, the reduction of H3K4me3 in the patient’s biological sample supports the dysfunction of KMT2B in DYT-<i>KMT2B.</i> Together with informatics approaches, our results suggest that <i>KMT2B</i> haploinsufficiency contributes to the DYT-<i>KMT2B</i> pathogenic process.
DOI: 10.6084/m9.figshare.23295740.v1
title: Supplementary Material for: Detection of Modified Histones from Oral Mucosa of a Patient with DYT-<i>KMT2B</i> Dystonia

description: <b><i>Introduction:</i></b> DYT-<i>KMT2B</i> is a rare childhood-onset, hereditary movement disorder typically characterized by lower-limb dystonia and subsequently spreads into the craniocervical and laryngeal muscles. Recently, <i>KMT2B</i>-encoding lysine (K)-specific histone methyltransferase 2B was identified as the causative gene for DYT-<i>KMT2B</i>, also known as DYT28. In addition to the fact that many physicians do not have sufficient experience or knowledge of hereditary dystonia, the clinical features of DYT-<i>KMT2B</i> overlap with those of other hereditary dystonia, and limited clinical biomarkers make the diagnosis difficult. <b><i>Methods:</i></b> Histone proteins were purified from the oral mucosa of patients with de novo <i>KMT2B</i> mutation causing premature stop codon, and then trimethylated fourth lysine residue of histone H3 (H3K4me3) which was catalyzed by KMT2B was analyzed by immunoblotting with specific antibody. We further analyzed the significance of H3K4me3 in patients with DYT-<i>KMT2B</i> using publicly available datasets. <b><i>Results:</i></b> H3K4me3 histone mark was markedly lower in the patient than in the control group. Additionally, a reanalysis of publicly available datasets concerning DNA methylation also demonstrated that <i>KMT2B</i> remained inactive in DYT-<i>KMT2B</i>. <b><i>Discussion:</i></b> Although only one case was studied due to the rarity of the disease, the reduction of H3K4me3 in the patient’s biological sample supports the dysfunction of KMT2B in DYT-<i>KMT2B.</i> Together with informatics approaches, our results suggest that <i>KMT2B</i> haploinsufficiency contributes to the DYT-<i>KMT2B</i> pathogenic process.
DOI: 10.6084/m9.figshare.10255475
title: Genetic structure of amphi-Atlantic Laminaria digitata reveals a unique range-edge gene pool and suggests post-glacial colonization of the NW Atlantic

description: Microsatellite data (12 loci) of 14 populations of Laminaria digitata covering the entire species range<br>
DOI: 10.6084/m9.figshare.10255475.v1
title: Genetic structure of amphi-Atlantic Laminaria digitata reveals a unique range-edge gene pool and suggests post-glacial colonization of the NW Atlantic

description: Microsatellite data (12 loci) of 14 populations of Laminaria digitata covering the entire species range<br>
DOI: 10.6084/m9.figshare.22691554.v1
title: Supplementary Material for: Brain Structural Correlates of Obstacle Negotiation in Mild Cognitive Impairment: Results from The Gait and Brain Study

description: Introduction- Mild Cognitive Impairment (MCI) affects obstacle negotiation capabilities, potentially increasing the risk of falls in older adults. However, it is unclear whether smaller brain volumes typically observed in older individuals with MCI are related to the observed hazardous obstacle negotiation in this population. Methods- A total of 93 participants (71.9±5.36years of age; MCI=53 / Control=40) from the Gait and Brain Study were analyzed. Gray matter (GM) volumes from the frontal, temporal and parietal lobes were entered in the analysis. Gait performance was recorded using a 6-m electronic walkway during two cognitive load conditions while approaching and stepping over an obstacle: 1) single-task; 2) while counting backwards by 1s from 100 (dual-task). Anticipatory adjustments in gait performance to cross an “ad hoc” obstacle were electronically measured during pre-crossing phases: early(3 steps before the late phase) and late(3 steps before obstacle). Association between the percentage of change in average gait speed and step length from early to late (i.e. anticipatory adjustments) and GM volumes were investigated using multivariate models adjusted for potential confounders. Results- Anticipatory adjustments in gait speed (Wilks’ lambda .35; eta2 .64; p=.01) and step length (Wilks’ lambda .33; eta2 .66; p=.01) during dual-task condition were globally associated with GM volumes in MCI. Individuals with MCI with smaller GM volumes in the left inferior frontal gyrus, left hippocampus, right hippocampus and right entorhinal cortex made significantly fewer anticipatory gait adjustments prior to crossing the obstacle. Discussion/Conclusion- Frontotemporal atrophy may affect obstacle negotiation capabilities potentially increasing the risk of falls in MCI.
DOI: 10.15151/esrf-es-1196500423
title: Heterodinuclear lanthanide complexes: Study of local ion electronic structure and magnetoelectric coupling in a molecular quantum gate proto

description: Quantum information processing using molecular systems is of paramount importance within the second quantum revolution, because of efficient addressing of quantum error-corrections. Among these systems hetero lanthanide (Ln) complexes are proposed as quantum gates. Although of great interest these complexes remain very rare and thus very little studied. We have synthesised a new family of pure heterodinuclear Ln complexes. We propose to study the magnetic properties of the individual Ln centres within the heterometallic assembly by X-ray Magnetocircular Dichroism (XMCD). Furthermore, the possible coupling of the local magnetic moments to electric fields, via the magnetoelectric coupling effect, can be exploited to control the Ln gates by external electric fields. We will investigate the occurrence of strong magnetoelectric coupling in these compounds by probing them for a magnetochiral response (X-ray Magnetochiral Dichroism, XMChiD).
DOI: 10.5281/zenodo.7901542
title: Data and supplementary materials in support of "Development and Preliminary Validation of an Open Access, Open Data and Open Outreach Indicator"

description: Data and supplementary materials in support of "Evgenios Vlachos, Regine Ejstrup, Thea Marie Drachen, Bertil Fabricius Dorch (2023) Development and Preliminary Validation of an Open Access, Open Data and Open Outreach Indicator, Frontiers in Research Metrics and Analytics, doi: 10.3389/frma.2023.1218213" It includes the anonymized dataset with the OADO values for all researchers from 10 departments (2 per faculty), the R code to perform the analysis and the graphs, the Scopus search string for the background search on Open Access and metrics, and the documentation for pulling data out from Pure.
DOI: 10.5281/zenodo.7901543
title: Data and supplementary materials in support of "Development and Preliminary Validation of an Open Access, Open Data and Open Outreach Indicator"

description: Data and supplementary materials in support of "Evgenios Vlachos, Regine Ejstrup, Thea Marie Drachen, Bertil Fabricius Dorch (2023) Development and Preliminary Validation of an Open Access, Open Data and Open Outreach Indicator, Frontiers in Research Metrics and Analytics" It includes the anonymized dataset with the OADO values for all researchers from 10 departments (2 per faculty), the R code to perform the analysis and the graphs, the Scopus search string for the background search on Open Access and metrics, and the documentation for pulling data out from Pure.
DOI: 10.5281/zenodo.8082868
title: Data and supplementary materials in support of "Development and Preliminary Validation of an Open Access, Open Data and Open Outreach Indicator"

description: Data and supplementary materials in support of "Evgenios Vlachos, Regine Ejstrup, Thea Marie Drachen, Bertil Fabricius Dorch (2023) Development and Preliminary Validation of an Open Access, Open Data and Open Outreach Indicator, Frontiers in Research Metrics and Analytics, doi: 10.3389/frma.2023.1218213" It includes the anonymized dataset with the OADO values for all researchers from 10 departments (2 per faculty), the R code to perform the analysis and the graphs, the Scopus search string for the background search on Open Access and metrics, and the documentation for pulling data out from Pure.
DOI: 10.57745/7uzl6y
title: doc00218920230110134931.pdf

description: 152Eu source information and photography.
DOI: 10.57745/0dvgh1
title: 113-152Eu_103mm_0001.fast

description: Binary data
DOI: 10.57745/ehg7ry
title: spectrum.png

description: Graphic representation of the `spectrum.h1.txt` data.
DOI: 10.57745/loguid
title: spectrum.h1.txt

description: Processed data into an energy histogram.
DOI: 10.57745/lq5me6
title: photos.pdf

description: Data deposit metadata.
DOI: 10.57745/pkitkl
title: c39490_labr_super_spec_1.pdf

description: Detector documentation.
DOI: 10.57745/pqmzbl
title: csp0071_2007-2007p_preamp_spec_sheet.pdf

description: Photomultiplier tube and preamplifier documentation.
DOI: 10.57745/b5gut4
title: metadata.yaml

description: Deposit metadata in yaml format
DOI: 10.57745/kagvzt
title: README.md

description: :unav
DOI: 10.57745/lcn0qy
title: schematic.pdf

description: Schematic of the source and detector position when recording the data.
DOI: 10.57745/neav2j
title: 113-152Eu_103mm.setup

description: Metadata associated with the data recorded in the .fast file
DOI: 10.6084/m9.figshare.22811300
title: Supplementary Material for: Arthritis in children with psychiatric deteriorations: a case series

description: Pediatric Acute-onset Neuropsychiatric Syndrome (PANS), Pediatric Autoimmune Neuropsychiatric Disorder Associated with Streptococcal infections (PANDAS), Sydenham chorea and other post-infectious psychiatric deteriorations are thought to be caused by inflammatory/autoimmune mechanisms, likely involving the basal ganglia based on imaging studies. Patients have a relapsing-remitting course and some develop severe refractory psychiatric disease. We found that 55/193 (28%) of consecutive patients meeting PANS criteria developed chronic arthritis and 25/121 (21%) of those with related psychiatric deteriorations developed chronic arthritis. Here we describe 7 of these patients in detail and one sibling. Many of our patients often have “dry” arthritis (no effusions found on physical exam), but subtle effusions detected by imaging and features of spondyloarthritis, enthesitis, and synovitis. Joint capsule thickening, not previously reported in children, is a common finding in the presented cases and in psoriatic arthritis in adults. Due to the severity of psychiatric symptoms in some cases, which often overshadow joint symptoms, and concomitant sensory dysregulation (making the physical exam unreliable in the absence of effusions), we rely on imaging to improve sensitivity and specificity of the arthritis classification. We also report the immunomodulatory treatments of these 7 patients (initially non-steroidal anti-inflammatory drugs and disease-modifying anti-rheumatic drugs with escalation to biologic medications) and note any coincidental changes to their arthritis and psychiatric symptoms while on immunomodulation. Conclusion: Patients with overlapping psychiatric syndromes and arthritis may have a unifying cause and pose unique challenges; a multi-disciplinary team can utilize imaging to tailor and coordinate treatment for this patient population.
DOI: 10.6084/m9.figshare.22811300.v1
title: Supplementary Material for: Arthritis in children with psychiatric deteriorations: a case series

description: Pediatric Acute-onset Neuropsychiatric Syndrome (PANS), Pediatric Autoimmune Neuropsychiatric Disorder Associated with Streptococcal infections (PANDAS), Sydenham chorea and other post-infectious psychiatric deteriorations are thought to be caused by inflammatory/autoimmune mechanisms, likely involving the basal ganglia based on imaging studies. Patients have a relapsing-remitting course and some develop severe refractory psychiatric disease. We found that 55/193 (28%) of consecutive patients meeting PANS criteria developed chronic arthritis and 25/121 (21%) of those with related psychiatric deteriorations developed chronic arthritis. Here we describe 7 of these patients in detail and one sibling. Many of our patients often have “dry” arthritis (no effusions found on physical exam), but subtle effusions detected by imaging and features of spondyloarthritis, enthesitis, and synovitis. Joint capsule thickening, not previously reported in children, is a common finding in the presented cases and in psoriatic arthritis in adults. Due to the severity of psychiatric symptoms in some cases, which often overshadow joint symptoms, and concomitant sensory dysregulation (making the physical exam unreliable in the absence of effusions), we rely on imaging to improve sensitivity and specificity of the arthritis classification. We also report the immunomodulatory treatments of these 7 patients (initially non-steroidal anti-inflammatory drugs and disease-modifying anti-rheumatic drugs with escalation to biologic medications) and note any coincidental changes to their arthritis and psychiatric symptoms while on immunomodulation. Conclusion: Patients with overlapping psychiatric syndromes and arthritis may have a unifying cause and pose unique challenges; a multi-disciplinary team can utilize imaging to tailor and coordinate treatment for this patient population.
DOI: 10.6084/m9.figshare.23274623.v1
title: Supplementary Material for: Hypertrophic pachymeningitis with persistent intrathecal inflammation secondary to neurosarcoidosis treated with intraventricular chemotherapy: a case report

description: Background: Hypertrophic pachymeningitis (HP) is a rare immune-mediated disease characterized by thickening of the dura mater with consecutive cranial neuropathy. While HP is usually treated with systemic immunotherapies, response to therapy is variable and may be limited by insufficient drug concentrations in the brain. We report on a patient with HP and marked lymphocytic pleocytosis refractory to various systemic immunotherapies, who was treated with intraventricular chemotherapy. Methods: A 57-year-old patient with HP manifesting with vision and hearing loss had sustained clinical progression despite various systemic immunotherapies. Intraventricular chemotherapy with methotrexate, cytarabine and dexamethasone was initiated. We present clinical, imaging and cerebrospinal fluid (CSF) findings, including cytokine levels before and after intraventricular treatment. Results: Rapid decrease of cell count, lactate and pro-fibrotic cytokine levels in the CSF following intraventricular chemotherapy was paralleled by a mild reduction of dura thickness in MRI. The already severely impaired visual acuity and hearing loss did not progress further. Treatment was complicated by exacerbation of previously subtle psychiatric symptoms. Follow-up was terminated after 6 months as the patient suffered from a fatal ischemic stroke. Autopsy revealed neurosarcoidosis as the underlying cause of HP. Conclusion: This case report suggests that intrathecal chemotherapy can reduce the inflammatory milieu in the CNS and should be considered for treatment-refractory HP before irreversible damage of cranial nerves has occurred.
DOI: 10.6084/m9.figshare.23274623
title: Supplementary Material for: Hypertrophic pachymeningitis with persistent intrathecal inflammation secondary to neurosarcoidosis treated with intraventricular chemotherapy: a case report

description: Background: Hypertrophic pachymeningitis (HP) is a rare immune-mediated disease characterized by thickening of the dura mater with consecutive cranial neuropathy. While HP is usually treated with systemic immunotherapies, response to therapy is variable and may be limited by insufficient drug concentrations in the brain. We report on a patient with HP and marked lymphocytic pleocytosis refractory to various systemic immunotherapies, who was treated with intraventricular chemotherapy. Methods: A 57-year-old patient with HP manifesting with vision and hearing loss had sustained clinical progression despite various systemic immunotherapies. Intraventricular chemotherapy with methotrexate, cytarabine and dexamethasone was initiated. We present clinical, imaging and cerebrospinal fluid (CSF) findings, including cytokine levels before and after intraventricular treatment. Results: Rapid decrease of cell count, lactate and pro-fibrotic cytokine levels in the CSF following intraventricular chemotherapy was paralleled by a mild reduction of dura thickness in MRI. The already severely impaired visual acuity and hearing loss did not progress further. Treatment was complicated by exacerbation of previously subtle psychiatric symptoms. Follow-up was terminated after 6 months as the patient suffered from a fatal ischemic stroke. Autopsy revealed neurosarcoidosis as the underlying cause of HP. Conclusion: This case report suggests that intrathecal chemotherapy can reduce the inflammatory milieu in the CNS and should be considered for treatment-refractory HP before irreversible damage of cranial nerves has occurred.