cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.15468/p2fcjk
title: A new species of the genus Apteroloma Hatch, 1927 (Coleoptera, Agyrtidae) from China

description: This dataset contains the digitized treatments in Plazi based on the original journal article Jiang, Ri-Xin, Zhang, Hong-Rui, Wang, Shuo (2021): A new species of the genus Apteroloma Hatch, 1927 (Coleoptera, Agyrtidae) from China. Zootaxa 4999 (5): 484-488, DOI: https://doi.org/10.11646/zootaxa.4999.5.7
DOI: 10.23708/rghhlq
title: Paysages vivants du versant Ouest de l'île de La Réunion, entre littoral urbanisé et forêt d'altitude

description: Ce jeu de données est constitué de neuf fiches descriptives de paysages et leur cartographie. Il s’appuie sur des campagnes d’observations paysagères de terrain entre 2012 et 2016 sur un cas d’étude du versant Ouest de l'île de La Réunion (partie Sud de la commune de Saint Paul, au sein de l’intercommunalité du TCO - Territoire Côte Ouest). Chaque fiche-paysage comprend les données issues de l’observation de terrain (liste des observés, éléments d’ambiance générale, sélection de photos illustratives) et le paysage interprété (nom, résumé, positionnement géographique et voisinage, fonctionnement et dynamique systémique, physionomie, occupation spatiale). Ces matériaux paysagers font appel au paysage en tant que manifestation tangible des interactions société-milieu et sont issus de l’application de la méthode OSYPCA d’analyse paysagère (Loireau et Fargette, 2021) au cas d’étude. La sensibilité (paysagère et systémique) des auteurs ne s’est pas arrêtée à leur domaine respectif (géographie rurale, géographie des îles et des littoraux, agronomie, biologie) ; l’ensemble de leur expertise s’est croisé en interdisciplinarité et s’est intéressé à l’occupation de l’île, son histoire, son devenir …, le paysage étant le médiateur parfait de cet exercice. L’élaboration de ces matériaux paysagers (observés et interprétés) est un processus dynamique qui laisse la possibilité de versions ultérieures enrichies. Description détaillée du jeu de données et de l’ensemble des documents associés : voir document PVR_00_D1-metadonnees.pdf. Reference : Loireau M et Fargette M., 2021. Science paysagère au service d’observatoires scientifiques Sociétés-Milieux en appui à la gestion territoriale. Journal of Interdisciplinary Methodologies and Issues in Sciences, Scientific observatories Environments/Societies, new challenges (sous presse)
DOI: 10.34810/data72/901
title: 02CO_1.MR.0004.0029.2013.03.10.17.33.16.406250.165477092.IMA
DOI: 10.21227/s1qk-xt91
title: Simulated Megaconstellation Ephemerides

description: Time-varying positions, velocities, and orbital elements of 1584 satellites ina simulated megaconstellation modelled on Phase 1 ofSpaceX’s Starlink.nbsp;
DOI: 10.34810/data72/902
title: 02CO_1.MR.0004.0184.2013.03.10.17.33.16.406250.165479889.IMA
DOI: 10.5281/zenodo.5119633
title: CD8+ T cell signature in acute SARS-CoV-2 infection identifies memory precursors

description: The datasets uploaded in this Zenodo entry were generated in the single cell RNA sequencing part of the project. For the scRNAseq analysis, cells from ten patients and the same time point were pooled together, generating four individual sample sets in total: (1) patients CoV2_T001- CoV2_T010, acute; (2) patients CoV2_T001- CoV2_T010, six months post-infection; (3) patients CoV2_T011- CoV2_T020, acute; (4) patients CoV2_T011- CoV2_T011-20, six months post-infection. We additionally generated two more sample sets: using 5000 unsorted PBMCs from each patient’s sample: (5) patients CoV2_T001- CoV2_T010, six months post-infection unsorted; (6) patients CoV2_T011- CoV2_T020, six months post-infection unsorted. Finally, using PBMCs from four healthy donors, we generated sample set (7) by sorting and pooling 2000 CD8+ T cells from each healthy donor sample. We are here providing the pre-processed sets for each sample set (1-7), i.e. :<br> - "filtered feature bc matrix" files, as output from the ‘cellranger multi’ pipeline (Cell Ranger version 5.0.0), containing cell-RNA count matrices and cell-ADT matrices. ADTs comprise counts for TotalSeq antibodies and dCODE Dextramers.<br> - "filtered_contig_annotations.csv" files, as output from the ‘cellranger multi’ pipeline (Cell Ranger version 5.0.0), containing High-level annotations of each high-confidence, cellular contig for TCR clonal analysis. This file is not present for sets 5 and 6, because we did not perform TCR profiling for these samples.<br> - "clusters.tsv" files, as output from the souporcell SNP analysis (version 2). To cluster cells based on their patient specific genetic variants, we merged sample sets 1, 2 and 5 (comprising sorted cells from both time points of patients CoV2_T001- CoV2_T010 and unsorted cells of the same patients) and sets 3, 4 and 6 (comprising cells from both time points of patients CoV2_T011- CoV2_T020 and unsorted cells of the same patients). Then, we executed the souporcell pipeline with option <em>k=10 </em>(number of clusters to be determined) for each of the two merged sample sets. Together, these files allow to reproduce the analysis as reported in the paper.
DOI: 10.34810/data72/903
title: 02CO_1.MR.0004.0165.2013.03.10.17.33.16.406250.165479547.IMA
DOI: 10.25934/00005674.0
title: Available IPD datapackage for study 'A Randomized, Double-blind Study of the Effect of Tocilizumab on Reduction in Signs and Symptoms in Patients With Moderate to Severe Active Rheumatoid Arthritis and Inadequate Response to DMARD Therapy'

description: Vivli is an independent, non-profit organization that has developed a global data-sharing and analytics platform to serve all elements of the international research community. Our mission is to promote, coordinate, and facilitate scientific sharing and reuse of clinical research data through the creation and implementation of a sustainable global data-sharing enterprise. The Vivli platform includes an independent data repository, in-depth search engine and a cloud-based, secure analytics platform.
DOI: 10.25934/00005674.1
title: IPD datapackage for study 'A Randomized, Double-blind Study of the Effect of Tocilizumab on Reduction in Signs and Symptoms in Patients With Moderate to Severe Active Rheumatoid Arthritis and Inadequate Response to DMARD Therapy' and research request: 'Predicting the Treatment Response of Biologics for Individual Patients with Rheumatoid Arthritis: An Individual Participant Data Meta-Analysis '

description: Vivli is an independent, non-profit organization that has developed a global data-sharing and analytics platform to serve all elements of the international research community. Our mission is to promote, coordinate, and facilitate scientific sharing and reuse of clinical research data through the creation and implementation of a sustainable global data-sharing enterprise. The Vivli platform includes an independent data repository, in-depth search engine and a cloud-based, secure analytics platform.
DOI: 10.6084/m9.figshare.15029361
title: Halisarca dujardini draft genomic scaffolds containing ferritin genes

description: Genomic DNA was isolated from sponge cells, the DNA library was prepared and sequenced, and the draft genome was assembled and annotated as described in the article. The published file constists of two scaffolds containing HdF1a/b and HdF2 ferritin genes.
DOI: 10.34810/data72/904
title: 02CO_1.MR.0004.0045.2013.03.10.17.33.16.406250.165477380.IMA
DOI: 10.25318/3310029901-eng
title: Required skills, by industry and enterprise size

description: Skills required by North American Industry Classification System (NAICS) code and enterprise size.
DOI: 10.25318/3310029901-fra
title: Compétences requises, selon l'industrie et la taille de l’entreprise

description: Compétences requises selon le code du Système de classification des industries de l'Amérique du Nord (SCIAN) et la taille de l'entreprise.
DOI: 10.34810/data72/905
title: 02CO_1.MR.0004.0071.2013.03.10.17.33.16.406250.165477848.IMA
DOI: 10.6084/m9.figshare.14884248
title: The genomes of nucleocytoplasmic large DNA viruses: viral evolution writ large

description: Supplementary Material for ‘The genomes of nucleocytoplasmic large DNA viruses: viral evolution writ large’, as published in <i>Microbial Genomics</i>.<br>
DOI: 10.6084/m9.figshare.14884248.v1
title: The genomes of nucleocytoplasmic large DNA viruses: viral evolution writ large

description: Supplementary Material for ‘The genomes of nucleocytoplasmic large DNA viruses: viral evolution writ large’, as published in <i>Microbial Genomics</i>.<br>
DOI: 10.6084/m9.figshare.12942223.v1
title: Strict network analysis of evolutionary conserved and brain-expressed genes reveals new putative candidates implicated in Intellectual Disability and in Global Development Delay

description: Intellectual Disability (ID) and Global Development Delay (GDD) are frequent reasons for referral to genetic services and although they present overlapping phenotypes concerning cognitive, motor, language, or social skills, they are not exactly synonymous. Aiming to better understand independent or shared mechanisms related to these conditions and to identify new candidate genes, we performed a highly stringent protein-protein interaction network based on genes previously related to ID/GDD in the Human Phenotype Ontology portal. ID/GDD genes were searched for reliable interactions through STRING and clustering analysis was applied to detect biological complexes through the MCL algorithm. Six coding hub genes (<i>TP53</i>, <i>CDC42</i>, <i>RAC1</i>, <i>GNB1</i>, <i>APP,</i> and <i>EP300</i>) were recognised by the Cytoscape NetworkAnalyzer plugin, interacting with 1625 proteins not yet associated with ID or GDD. Genes encoding these proteins were explored by gene ontology, associated diseases, evolutionary conservation, and brain expression. One hundred and seventy-two new putative genes playing a role in enriched processes/pathways previously related to ID and GDD were revealed, some of which were already postulated to be linked to ID/GDD in additional databases. Our findings expanded the aetiological genetic landscape of ID/GDD and showed evidence that both conditions are closely related at the molecular and functional levels.
DOI: 10.6084/m9.figshare.13078678
title: Genetic variants in miRNAs differentially expressed during brain development and their relevance to psychiatric disorders susceptibility

description: MicroRNAs (miRNAs) play an important regulatory role in the expression of genes involved in brain functions during development. Genetic variants in miRNA genes may impact their regulatory function and lead to psychiatric disorders. To evaluate the role of genetic variants in genes of miRNAs differentially expressed during neurodevelopment on autism spectrum disorder (ASD), attention deficit/hyperactivity disorder (ADHD), schizophrenia (SCZ), and major depressive disorder (MDD). The miRNAs were identified in the literature. Summary statistics from the most recent genome-wide association studies to date were used to evaluate the association between the selected polymorphisms and each disorder in a look-up approach. In a global analysis, we compared the standardised risk effect of variants in neurodevelopment-related miRNAs with those in the remaining miRNAs from miRBase. The global analysis showed that variants in neurodevelopment-related miRNAs had higher risk effects compared to the other miRNAs for SCZ (<i>p</i> = 0.010) and ADHD (<i>p</i> = 0.001). <i>MIR33B, MIR29B2</i>, <i>MIR29C, MIR137</i>, and <i>MIR135A1</i> were significantly associated with SCZ, while 55.9% of the miRNAs were at least nominally associated with one or more psychiatric disorders (<i>p</i> Genetic variants in neurodevelopment-related miRNAs play an important role in the genetic susceptibility of psychiatric disorders, mainly SCZ and ADHD.
DOI: 10.6084/m9.figshare.13078678.v1
title: Genetic variants in miRNAs differentially expressed during brain development and their relevance to psychiatric disorders susceptibility

description: MicroRNAs (miRNAs) play an important regulatory role in the expression of genes involved in brain functions during development. Genetic variants in miRNA genes may impact their regulatory function and lead to psychiatric disorders. To evaluate the role of genetic variants in genes of miRNAs differentially expressed during neurodevelopment on autism spectrum disorder (ASD), attention deficit/hyperactivity disorder (ADHD), schizophrenia (SCZ), and major depressive disorder (MDD). The miRNAs were identified in the literature. Summary statistics from the most recent genome-wide association studies to date were used to evaluate the association between the selected polymorphisms and each disorder in a look-up approach. In a global analysis, we compared the standardised risk effect of variants in neurodevelopment-related miRNAs with those in the remaining miRNAs from miRBase. The global analysis showed that variants in neurodevelopment-related miRNAs had higher risk effects compared to the other miRNAs for SCZ (<i>p</i> = 0.010) and ADHD (<i>p</i> = 0.001). <i>MIR33B, MIR29B2</i>, <i>MIR29C, MIR137</i>, and <i>MIR135A1</i> were significantly associated with SCZ, while 55.9% of the miRNAs were at least nominally associated with one or more psychiatric disorders (<i>p</i> Genetic variants in neurodevelopment-related miRNAs play an important role in the genetic susceptibility of psychiatric disorders, mainly SCZ and ADHD.
DOI: 10.6084/m9.figshare.12942221
title: KEOPS complex expression in the frontal cortex in major depression and schizophrenia

description: Recently, the presence of a complete five subunit Kinase, Endopeptidase and Other Proteins of small Size (KEOPS) complex was confirmed in humans. The highly conserved KEOPS protein complex has established roles in tRNA modification, protein translation and telomere homeostasis in yeast, but little is known about KEOPS mRNA expression and function in human brain and disease. Here, we characterise KEOPS expression in post-mortem tissue from subjects diagnosed with major depression (MDD) and schizophrenia and assess whether KEOPS is associated with telomere length dysregulation in neuropsychiatric disorders. We assessed mRNA expression of KEOPS complex subunits TP53RK, TPRKB, GON7, LAGE3, OSGEP, and OSGEP mitochondrial ortholog OSGEPL1 in the dorsolateral prefrontal cortex (DLPFC) of subjects with MDD, schizophrenia and matched non-psychiatrically ill controls (<i>n</i> = 20 per group) using qPCR. We conducted bioinformatic analysis using Kaleidoscope, data mining post-mortem transcriptomic datasets to characterise KEOPS expression in human brain. Finally, we assayed relative telomere length in the DLPFC using a qPCR-based assay and carried out correlation analysis with KEOPS subunit mRNA expression to determine if the KEOPS complex is associated with telomere length dysregulation in neuropsychiatric disorders. There were no significant changes in KEOPS mRNA expression in the DLPFC in MDD or schizophrenia compared to non-psychiatrically ill controls. Relative telomere length was not significantly altered in MDD or schizophrenia, nor was there an association between relative telomere length and KEOPS subunit gene expression in these subjects. This study is the first to describe KEOPS complex expression in post-mortem brain and neuropsychiatric disorders. KEOPS subunit mRNA expression is not significantly altered in the DLPFC in MDD or schizophrenia. Unlike in yeast, the KEOPS complex does not appear to play a role in telomere length regulation in humans or in neuropsychiatric disorders.
DOI: 10.6084/m9.figshare.12942221.v2
title: KEOPS complex expression in the frontal cortex in major depression and schizophrenia

description: Recently, the presence of a complete five subunit Kinase, Endopeptidase and Other Proteins of small Size (KEOPS) complex was confirmed in humans. The highly conserved KEOPS protein complex has established roles in tRNA modification, protein translation and telomere homeostasis in yeast, but little is known about KEOPS mRNA expression and function in human brain and disease. Here, we characterise KEOPS expression in post-mortem tissue from subjects diagnosed with major depression (MDD) and schizophrenia and assess whether KEOPS is associated with telomere length dysregulation in neuropsychiatric disorders. We assessed mRNA expression of KEOPS complex subunits TP53RK, TPRKB, GON7, LAGE3, OSGEP, and OSGEP mitochondrial ortholog OSGEPL1 in the dorsolateral prefrontal cortex (DLPFC) of subjects with MDD, schizophrenia and matched non-psychiatrically ill controls (<i>n</i> = 20 per group) using qPCR. We conducted bioinformatic analysis using Kaleidoscope, data mining post-mortem transcriptomic datasets to characterise KEOPS expression in human brain. Finally, we assayed relative telomere length in the DLPFC using a qPCR-based assay and carried out correlation analysis with KEOPS subunit mRNA expression to determine if the KEOPS complex is associated with telomere length dysregulation in neuropsychiatric disorders. There were no significant changes in KEOPS mRNA expression in the DLPFC in MDD or schizophrenia compared to non-psychiatrically ill controls. Relative telomere length was not significantly altered in MDD or schizophrenia, nor was there an association between relative telomere length and KEOPS subunit gene expression in these subjects. This study is the first to describe KEOPS complex expression in post-mortem brain and neuropsychiatric disorders. KEOPS subunit mRNA expression is not significantly altered in the DLPFC in MDD or schizophrenia. Unlike in yeast, the KEOPS complex does not appear to play a role in telomere length regulation in humans or in neuropsychiatric disorders.
DOI: 10.6084/m9.figshare.12942223
title: Strict network analysis of evolutionary conserved and brain-expressed genes reveals new putative candidates implicated in Intellectual Disability and in Global Development Delay

description: Intellectual Disability (ID) and Global Development Delay (GDD) are frequent reasons for referral to genetic services and although they present overlapping phenotypes concerning cognitive, motor, language, or social skills, they are not exactly synonymous. Aiming to better understand independent or shared mechanisms related to these conditions and to identify new candidate genes, we performed a highly stringent protein-protein interaction network based on genes previously related to ID/GDD in the Human Phenotype Ontology portal. ID/GDD genes were searched for reliable interactions through STRING and clustering analysis was applied to detect biological complexes through the MCL algorithm. Six coding hub genes (<i>TP53</i>, <i>CDC42</i>, <i>RAC1</i>, <i>GNB1</i>, <i>APP,</i> and <i>EP300</i>) were recognised by the Cytoscape NetworkAnalyzer plugin, interacting with 1625 proteins not yet associated with ID or GDD. Genes encoding these proteins were explored by gene ontology, associated diseases, evolutionary conservation, and brain expression. One hundred and seventy-two new putative genes playing a role in enriched processes/pathways previously related to ID and GDD were revealed, some of which were already postulated to be linked to ID/GDD in additional databases. Our findings expanded the aetiological genetic landscape of ID/GDD and showed evidence that both conditions are closely related at the molecular and functional levels.
DOI: 10.6084/m9.figshare.12942221.v1
title: KEOPS complex expression in the frontal cortex in major depression and schizophrenia

description: <b>Objectives.</b> Recently, the presence of a complete five subunit Kinase, Endopeptidase and Other Proteins of small Size (KEOPS) complex was confirmed in humans. The highly conserved KEOPS protein complex has established roles in tRNA modification, protein translation and telomere homeostasis in yeast, but little is known about KEOPS mRNA expression and function in human brain and disease. Here, we characterize KEOPS expression in postmortem tissue from subjects diagnosed with major depression (MDD) and schizophrenia and assess whether KEOPS is associated with telomere length dysregulation in neuropsychiatric disorders. <b>Methods.</b> We assessed mRNA expression of KEOPS complex subunits TP53RK, TPRKB, GON7, LAGE3, OSGEP, and OSGEP mitochondrial ortholog OSGEPL1 in the dorsolateral prefrontal cortex (DLPFC) of subjects with MDD, schizophrenia and matched non-psychiatrically ill controls (n = 20 per group) using qPCR. We conducted bioinformatic analysis using Kaleidoscope, data mining postmortem transcriptomic datasets to characterize KEOPS expression in human brain. Finally, we assayed relative telomere length in the DLPFC using a qPCR-based assay and carried out correlation analysis with KEOPS subunit mRNA expression to determine if the KEOPS complex is associated with telomere length dysregulation in neuropsychiatric disorders. <b>Results.</b> There were no significant changes in KEOPS mRNA expression in the DLPFC in MDD or schizophrenia compared to non-psychiatrically ill controls. Relative telomere length was not significantly altered in MDD or schizophrenia, nor was there an association between relative telomere length and KEOPS subunit gene expression in these subjects. <b>Conclusions.</b> This study is the first to describe KEOPS complex expression in postmortem brain and neuropsychiatric disorders. KEOPS subunit mRNA expression is not significantly altered in the DLPFC in MDD or schizophrenia. Unlike in yeast, the KEOPS complex does not appear to play a role in telomere length regulation in humans or in neuropsychiatric disorders.
DOI: 10.25934/00005678.1
title: Available IPD datapackage for study 'A Randomized, Double-blind Study of Safety and Reduction in Signs and Symptoms During Treatment With Tocilizumab Monotherapy Versus Methotrexate Monotherapy in Patients With Moderate to Severe Active Rheumatoid Arthritis'

description: Vivli is an independent, non-profit organization that has developed a global data-sharing and analytics platform to serve all elements of the international research community. Our mission is to promote, coordinate, and facilitate scientific sharing and reuse of clinical research data through the creation and implementation of a sustainable global data-sharing enterprise. The Vivli platform includes an independent data repository, in-depth search engine and a cloud-based, secure analytics platform.
DOI: 10.34810/data72/906
title: 02CO_1.MR.0004.0126.2013.03.10.17.33.16.406250.165478838.IMA
DOI: 10.25934/00005678.2
title: IPD datapackage for study 'A Randomized, Double-blind Study of Safety and Reduction in Signs and Symptoms During Treatment With Tocilizumab Monotherapy Versus Methotrexate Monotherapy in Patients With Moderate to Severe Active Rheumatoid Arthritis' included in Research Request: 'Predicting the Treatment Response of Adalimumab for Individual Patients with Rheumatoid Arthritis: An Individual Participant Data Meta-Analysis '

description: Vivli is an independent, non-profit organization that has developed a global data-sharing and analytics platform to serve all elements of the international research community. Our mission is to promote, coordinate, and facilitate scientific sharing and reuse of clinical research data through the creation and implementation of a sustainable global data-sharing enterprise. The Vivli platform includes an independent data repository, in-depth search engine and a cloud-based, secure analytics platform.
DOI: 10.34810/data72/907
title: 02CO_1.MR.0004.0023.2013.03.10.17.33.16.406250.165476984.IMA
DOI: 10.25318/3310030001-eng
title: Skill shortages, by industry and enterprise size

description: Duration of skill shortages by North American Industry Classification System (NAICS) code and enterprise size.
DOI: 10.25318/3310030001-fra
title: Pénuries de compétences, selon l'industrie et la taille de l’entreprise

description: Durée des pénurie de compétences selon le code du Système de classification des industries de l'Amérique du Nord (SCIAN) et la taille de l'entreprise.