cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.19085771.v1
title: Supplementary Material for: Therapeutic Approach for Recurrent Focal Segmental Glomerulosclerosis in Pediatric Renal Transplant Recipients: A Single-Center Experience

description: <b><i>Introduction:</i></b> Recurrence of focal segmental glomerulosclerosis (FSGS) after kidney transplantation (KTx) develops in 40% of patients, leading to graft loss in half of cases. Extracorporeal apheretic treatments, combined with immunosuppressive drugs, seem to be the most promising therapies, but at now limited reports are available, mainly in pediatric patients. <b><i>Objective:</i></b> We aimed to assess the efficacy of immunoadsorption (IA) to treat recurrent FSGS in pediatric patients. <b><i>Methods:</i></b> We report a case series of 4 pediatric patients (aged 4–12 years) followed at our institution for early recurrent FSGS after KTx. FSGS recurrence was treated with early and intensive apheretic treatments IA. <b><i>Results:</i></b> After IA initiation, a partial remission (PR) of proteinuria at 24-month follow-up was achieved only in 1 patient. The others showed a mild reduction of nephrotic proteinuria, without PR, but gained a significant improvement in clinical signs of nephrotic syndrome (reduction of edema, increased serum albumin, and total protein levels). After a median follow-up of 38 (22–48) months, renal function was almost stable over time in all patients, except one who returned to hemodialysis after 22 months. No severe IA-related complications occurred. <b><i>Conclusions:</i></b> According to our clinical experience, IA revealed as a safe and effective therapy to treat patients with recurrent FSGS after KTx and it could maintain stable renal function in 75% of patients.
DOI: 10.6084/m9.figshare.21249648.v1
title: Transcript Annotation

description: Basic annotations and summary statistics for transcripts including mRNAs, lncRNAs and circRNAs identified for human and mouse species via ASJA program and CIRI2 software.
DOI: 10.6084/m9.figshare.28219994.v1
title: Merged dataset

description: Merged dataset from "Local selection shaped the diversity of European maize landraces".All data used in the present study are publicly available (Unterseer <i>et al</i>. 2016; Mayer <i>et al</i>. 2017, 2020). In brief, all individuals used were genotyped at high density with the 600k Affymetrix® Axiom® Maize Array, which is comprised of 616,201 variants, of which 6,759 represent insertions/deletions (Unterseer et al. 2014, 2016). Specifically, 941 DH lines derived from 2 European landraces were taken from Mayer <i>et al</i>. (2020), which were divided as follows: 501 DH lines of Kemater Landmais Gelb (KL; Austria) and 409 of Petkuser Ferdinand Rot (PE; Germany). 952 individuals from 35 European maize landraces from Mayer <i>et al</i>. (2017). Lastly, 3 landraces from Unterseer <i>et al</i>. (2016) and 155 elite lines were added from Unterseer <i>et al</i>. (2016). The final panel had in total 2,954 individuals (Table S1).
DOI: 10.6084/m9.figshare.22340443.v1
title: Supplementary Material for: Air versus Gas Tamponade for Primary Rhegmatogenous Retinal Detachment: A Systematic Review and Meta-analysis

description: Background: Air tamponade’s effectiveness in treatment of rhegmatogenous retinal detachment (RRD) remains unclear. Objective: We aimed to review the surgical outcomes between air and gas tamponade after vitrectomy for RRD. Method: PubMed, Cochrane Library, EMBASE, and Web of Science were reviewed. The study protocol was registered in the International Prospective Register of Systematic Reviews (PROSPERO CRD42022342284). The primary outcome was the primary anatomical success after vitrectomy. The secondary outcome was the prevalence of postoperative ocular hypertension. Certainty of evidence was evaluated using the Grading of Recommendations Assessment, Development, and Evaluation system. Results: Ten studies involving 2677 eyes were included. One study was randomized, and the others were non-randomized. The primary anatomical success after vitrectomy was not significantly different between the air and gas groups (odds ratio [OR], 1.00; 95% confidence interval [CI], 0.68–1.48). The risk of ocular hypertension was significantly lower in the air group (OR, 0.14; 95% CI, 0.09–0.24). The certainty of evidence regarding air tamponade having an comparable anatomical outcome and lower frequency of postoperative ocular hypertension in treatment of RRD were low. Discussion: The current evidence base for tamponade selection in treatment of RRD has several major limitations. Further appropriately designed studies are needed to guide tamponade selection.
DOI: 10.25452/figshare.plus.25115169.v1
title: Dataset supporting Figure S6_E210 in "Pan-cortical 2-photon mesoscopic imaging and neurobehavioral alignment in awake, behaving mice"

description: Contains data from a single 1-photon widefield imaging experiment and a single Thorlabs mesoscope 2-photon imaging session from the same dorsal mount mouse as in Figure 4 (but a different session than in that Figure), corresponding to panels a-c of Figure S6. Included files contain imaging data, behavioral data, and python files with combined neurobehavioral data. Additional python files corresponding to this session can be found in the FigShare+ folder in this collection corresponding to Figure 2.Note that session names have the following format: "mouse#_bigEndianDate_cage#_info_session#_attempt#".Raw mesoscope imaging data is included in ScanImage rendered format as single big tiffs with the following nomenclature: "filename_2D.tiff".Mouse face and body cam images are included as standalone or concatenated .avi movie files, and behavioral data is included both as Spike2 files (smrx) and in exported form at Matlab data files (.mat).In all cases the first frame of the 2-photon movie, the right face/body movie, and Spike2 data are aligned to the first Labview-issued frameclock trigger (also recorded in Spike2, along with all other frameclock events). 2-photon triggers were sometimes incorrectly recorded in Spike2 (generally we recorded these as both events and waveforms), but were in all cases additionally exported from ScanImage tiff metadeta as timestamps (csv files ending in <i>header.csv). </i>Session start-time timestamps, also exported from ScanImage tiff metadata, appear as .txt files ending in "_starttime.txt".Preprocessed data (python) can be found in npy files with various names, each containing different subsets of variables relevant to the analysis. For each session, the npy file containing the string "standard_frames" contains the most complete, final stage set of preprocessed neurobehavioral data (in combined DataFrame format, exportable to nwb), including CCF/MMM alignments. The file containing the string "nb_dump" contains a large set of auxilliary variables that may be needed for additional preprocessing.Additional image files (tiff, png) and excel worksheets (xlsx, csv) containing high-level data summaries and records of intermediate analysis steps are also included.Please contact the authors for any additional clarifications as needed.See related materials in Collection at: https://doi.org/10.25452/figshare.plus.c.7052513
DOI: 10.6084/m9.figshare.15132468.v1
title: Simulated Outcomes following Carotid Artery Laceration

description: This is a data release for the Simulated Outcomes following Carotid Artery Laceration (SOCAL) dataset version 1. Please see the SOCAL_README.txt file for a complete description of the dataset.<br>If you plan to publish work that used this dataset in any capacity, please cite this data release.<br>These are neurosurgical training exercise videos performed on cadaveric models. These simulations contain no patient data, no protected health information, and are not derived from patient care settings. All video is owned by the Department of Neurosurgery at the University of Southern California. Please see the SOCAL_README.txt for correspondence information.
DOI: 10.6084/m9.figshare.20346711.v1
title: 20150124 DictyPT2 S4 Bi3+ SM+FGON 0.21pA 3scans FOV 200 007.itm

description: 25 keV Bi3+ HCBU mode, measurement file, TOF-SIMS 5.
DOI: 10.6084/m9.figshare.24903018.v1
title: Supplementary Material for: Dapagliflozin ameliorates ovulation disorders via attenuating activated microglia-mediated hypothalamic inflammation in HFD-fed mice

description: Introduction: Sodium-glucose cotransporter 2 inhibitors (SGLT2i) have shown neuroprotective effects in obese mice. However, whether SGLT2i can ameliorate high-fat diet (HFD)-related ovulation disorders remains unknown. The aim of this research was to investigate whether dapagliflozin improves HFD-induced ovulatory dysfunction by attenuating microglia-mediated hypothalamic inflammation. Methods: C57BL/6J female mice fed HFD were treated with dapagliflozin (1mg/kg) for 22 weeks. Plasma insulin, leptin, luteinizing hormone (LH), estradiol (E2), and IL-1β levels were also tested. Microglial morphology, cell numbers and SGLT2 expression were evaluated using immunofluorescence. The expression of IL-1, NLRP3, Kisspeptin, GnRH, SGLT2, insulin, and leptin receptors in the hypothalamus was determined using immunohistochemical staining. We also examined the effects of dapagliflozin on glucose metabolism and the release of inflammatory factor in palmitic acid (PA)-treated HMC3 cells. Results: As expected, dapagliflozin improved HFD-induced metabolic disturbances, peripheral versus central insulin and leptin resistance, and also restored the regular estrous cycle. Furthermore, dapagliflozin blunted microglia activation, NLRP3 inflammasome priming, hypothalamic inflammation, and increased the expression of gonadotropin-releasing hormone (GnRH) and Kisspeptin at proestrus in the hypothalamus. Additionally, dapagliflozin markedly reduced IL-6 and NO release and fat accumulation, decreased lactic acid production and glucose consumption, and inhibited mammalian target of rapamycin (mTOR) and hexokinase 2 (HK2) expression in PA-treated HMC3 cells. These effects suggest that dapagliflozin reduced the mTOR/HK2-mediated aerobic glycolysis. Conclusions: Dapagliflozin improved HFD-related ovulation disorders by regulating glucose metabolism through mTOR/HK2 signaling and attenuating microglia-mediated hypothalamic inflammation. These results validate the novel role for the neuroprotection of SGLT2i in HFD-induced obesity and ovulation disorders.
DOI: 10.6084/m9.figshare.28793900.v1
title: Supplementary Material for: Central Diabetes Insipidus in Father and Son Linked to a Rare Variant: A Case Report

description: <b><i>Introduction:</i></b> Central diabetes insipidus (CDI) is a rare disorder caused by a deficiency in the secretion of arginine vasopressin (AVP) from the posterior pituitary. It can be either acquired or congenital, often due to genetic factors, and is typically inherited in an autosomal dominant manner. <b><i>Case Presentation:</i></b> This study describes the clinical features and the genetic analysis of a father and his son with familial CDI. Both presented in childhood with typical symptoms, including polyuria, polydipsia, and hypernatremia. Diagnosis was confirmed through water deprivation testing and subsequently supported by sellar magnetic resonance imaging. Genetic analysis identified the rare germline variant c.329G&gt;A (p.Cys110Tyr) in the <i>AVP</i> gene, in heterozygosity, which segregated in the parent-child pair, thereby elucidating the familial basis of the CDI. <b><i>Conclusion:</i></b> This rare germline <i>AVP</i> variant causes a cysteine-to-tyrosine amino acid substitution in the encoded protein and is classified as pathogenic. Familial cases of rare diseases, such as CDI, highlight the importance of clinical evaluation of relatives with similar symptoms and emphasize the need for molecular studies and genetic counseling.
DOI: 10.6084/m9.figshare.5121676.v1
title: Supplementary Material for: Nuclear Receptor Coactivators Are Coexpressed with Steroid Receptors and Regulated by Estradiol in Mouse Brain

description: <i>Background/Aims:</i> The steroid hormones, including estradiol (E) and progesterone, act in the brain to regulate female reproductive behavior and physiology. These hormones mediate many of their biological effects by binding to their respective intracellular receptors. The receptors for estrogens (ER) and progestins (PR) interact with nuclear receptor coactivators to initiate transcription of steroid-responsive genes. Work from our laboratory and others reveals that nuclear receptor coactivators, including steroid receptor coactivator-1 (SRC-1) and SRC-2, function in brain to modulate ER-mediated induction of the PR gene and hormone-dependent behaviors. In order for steroid receptors and coactivators to function together, both must be expressed in the same cells. <i>Methods:</i> Triple-label immunofluorescence was used to determine if E-induced PR cells also express SRC-1 or SRC-2 in reproductively relevant brain regions of the female mouse. <i>Results:</i> The majority of E-induced PR cells in the medial preoptic area (61%), ventromedial nucleus of the hypothalamus (63%) and arcuate nucleus (76%) coexpressed both SRC-1 and SRC-2. A smaller proportion of PR cells expressed either SRC-1 or SRC-2, while a few PR cells expressed neither coactivator. In addition, compared to control animals, 17β-estradiol benzoate (EB) treatment increased SRC-1 levels in the arcuate nucleus, but not the medial preoptic area or the ventromedial nucleus of the hypothalamus. EB did not alter SRC-2 expression in any of the three brain regions analyzed. <i>Conclusions:</i> Taken together, the present findings identify a population of cells in which steroid receptors and nuclear receptor coactivators may interact to modulate steroid sensitivity in brain and regulate hormone-dependent behaviors in female mice. Given that cell culture studies reveal that SRC-1 and SRC-2 can mediate distinct steroid-signaling pathways, the present findings suggest that steroids can produce a variety of complex responses in these specialized brain cells.
DOI: 10.6084/m9.figshare.16557969.v1
title: Supplementary Material for: Developing a Novel Measurement of Sleep in Rheumatoid Arthritis: Study Proposal for Approach and Considerations

description: The development of novel digital endpoints (NDEs) using digital health technologies (DHTs) may provide opportunities to transform drug development. It requires a multidisciplinary, multi-study approach with strategic planning and a regulatory-guided pathway to achieve regulatory and clinical acceptance. Many NDEs have been explored; however, success has been limited. To advance industry use of NDEs to support drug development, we outline a theoretical, methodological study as a use-case proposal to describe the process and considerations when developing and obtaining regulatory acceptance for an NDE to assess sleep in patients with rheumatoid arthritis (RA). RA patients often suffer joint pain, fatigue, and sleep disturbances (SDs). Although many researchers have investigated the mobility of joint functions using wearable technologies, the research of SD in RA has been limited due to the availability of suitable technologies. We proposed measuring the improvement of sleep as the novel endpoint for an anti-TNF therapy and described the meaningfulness of the measure, considerations of tool selection, and the design of clinical validation. The recommendations from the FDA patient-focused drug development guidance, the Clinical Trials Transformation Initiative (CTTI) pathway for developing novel endpoints from DHTs, and the V3 framework developed by the Digital Medicine Society (DiMe) have been incorporated in the proposal. Regulatory strategy and engagement pathways are also discussed.
DOI: 10.6084/m9.figshare.13567307.v1
title: Black carbon and secondary brown carbon, the dominant light absorption and direct radiative forcing contributors of the atmospheric aerosols over the Tibetan Plateau

description: Black carbon (BC), primary brown carbon (BrCpri), and secondary brown carbon (BrCsec) are important light-absorbing aerosol. BC and BrC from the surrounding area can reach the Tibetan Plateau (TP) and influence climate change and glacial melting. Here, we presented a study of the light absorption, radiative forcing, and potential source areas of BC and BrC over the northeastern, central, and southwestern TP. The higher light absorption was observed in the northeastern and southwestern sites compared to the central TP site. The major carbonaceous light-absorbing was attributed to BC with the percentages of 65%, 56%, and 82% in Ngari, Qinghai Lake, and Beiluhe, respectively. The heighten contribution of BrCsec to total light absorption indicated the importance of BrCsec in the TP, especially in the northeastern and southwestern areas. The BrCsec radiative forcings relative to BC were much higher than those of BrCpri. The potential BC and BrCpri source distributions were obtained.<br>
DOI: 10.6084/m9.figshare.26840068.v1
title: Weed risk assessment in Tenerife.xlsx

description: This database includes alien species from the Asparagaceae, Cactaceae, Crassulaceae, Fabaceae, and Poaceae families found in Tenerife. Each species has been evaluated using the 'Australian Weed Risk Assessment system’ (Pheloung et al., 1999) and the ‘Risk Assessment for Central Europe’ (Weber & Gut, 2004).
DOI: 10.6084/m9.figshare.5488093.v1
title: Supplementary Material for: Increased Platelet-Monocyte Interaction in Stable COPD in the Absence of Platelet Hyper-Reactivity

description: <b><i>Background:</i></b> Chronic obstructive pulmonary disease (COPD) is well known for its cardiovascular co-morbidities. Increased platelet-monocyte interaction is found in COPD and may reflect altered platelet function and a potential role for anti-platelet therapy. <b><i>Objectives:</i></b> The objectives were to investigate platelet-monocyte interaction, platelet activation and reactivity and plasmatic coagulation in stable COPD. <b><i>Methods:</i></b> Platelet-monocyte interaction and platelet activation were determined by flow cytometry in 30 stable COPD patients and 25 controls. Platelet activation was measured by binding of fibrinogen to the activated fibrinogen receptor and platelet P-selectin expression at baseline and after platelet stimulation with platelet agonists. Plasmatic coagulation was measured by D-dimer and thrombin generation. <b><i>Results:</i></b> Platelet-monocyte interaction was increased in stable COPD (median fluorescence intensity of platelet CD61 was 19.8 [IQR 14.0-33.2] vs. 10.0 [IQR 8.7-16.7], <i>p</i> = 0.002). In contrast, platelet activation and reactivity, reflected by fibrinogen binding and P-selectin expression, were the same in both groups. Plasma P-selectin and interleukin-6 were increased in COPD (<i>p</i> = 0.01 and <i>p</i> = 0.02, respectively), whereas soluble fibrinogen, D-dimer and thrombin generation were similar. <b><i>Conclusions:</i></b> Increased platelet-monocyte interaction was found in the absence of platelet hyper-reactivity and activation of plasmatic coagulation in stable COPD. Future clinical evaluation of the effects of different anti-platelet drugs in COPD is warranted, as anti-platelet therapy may interfere with platelet-monocyte interaction.
DOI: 10.6084/m9.figshare.28806041.v1
title: Date.5.2 案例 2.zip

description: 成本控制拓扑优化MATLAB 代码和结果数据
DOI: 10.6084/m9.figshare.12386135.v1
title: MERRA data

description: Title: MERRA-2 inst3_3d_aer_Nv: 3d,3-Hourly,Instantaneous,Model-Level,Assimilation,Aerosol Mixing Ratio V5.12.4Version: 5.12.4Creator: Global Modeling and Assimilation Office (GMAO)Publisher: Goddard Earth Sciences Data and Information Services Center (GES DISC)Release Date: 2015-06-30T00:00:00.000ZLinkage:https://disc.gsfc.nasa.gov/datacollection/M2I3NVAER_5.12.4.html
DOI: 10.6084/m9.figshare.3557613.v1
title: Appendix C. Disturbance-induced differences in ecosystem functions.

description: Disturbance-induced differences in ecosystem functions.
DOI: 10.6084/m9.figshare.12816095.v1
title: Local_Cadre V2_5.dta

description: Data used in the paper "Exploring Political Personalities: the Microfoundation of Local Innovation in China." Includes all of the original data as well as variable transformations that are used in the paper. We have also supplied the Stata log files that we used to create a paper for replicability purposes. A complete list of survey questions and the survey instrument for this study can be found with the accompanying methodological appendix for the paper, also stored hear as part of this project. <br>
DOI: 10.6084/m9.figshare.24792693.v3
title: RF for IDC and ILC-F1000

description: Among women, breast cancer(BC) is one of the main causes of cancer-related mortality. For clinical management to help patients survive longer and spend less on treatment, early and precise cancer identification and differentiation of lesions of the breast are crucial. To investigate the accuracy of radiomic features (RF) extracted from Dynamic Contrast Enhanced (DCE) MRI for differentiation of Invasive ductal carcinoma (IDC) and Invasive lobular carcinoma (ILC).
DOI: 10.6084/m9.figshare.26332171.v1
title: <b>Effect of high-intensity anaerobic exercise on electrocortical activity in athletes and non-athletes</b>

description: <b>OBJECTIVE: The present study aims to verify the changes in information processing in athletes through electroencephalography, analyzing cortical areas responsible for cognitive functions related to attentional processing of visual stimuli and investigating motor activity's influence on cognitive aspects. METHODS: The sample consisted of 29 subjects, divided into an experimental group (n = 13 modern pentathlon athletes) and a control group (n = 16 non-athletes). We collected the electrocortical activity before and after the Wingate Anaerobic Test. During the electrophysiological measures, the volunteers performed a saccadic eye movement paradigm. They also performed cognitive tasks, resting heart rate, and anthropometric measurements. RESULTS: There was an interaction for the group vs. moment factors in the frontal and parietal areas, only for the right hemisphere (F3, F4, P3, and P4). We found the main effect for group factors in the frontal and parietal electrodes of the right hemisphere (F4 and P4) and a main effect of the moment factor on the frontal (F3 and F4) and parietal (P3 and P4) electrodes. There was an interaction between the group vs. moment factors for the reaction time. The groups were different in Peak Power (Watts/kg), Average Power (Watts/kg), Fatigue Index (%), and Maximum Power (ms). Finally, in Heart Rate (HR) measurements, there were differences between groups for resting heart rate and heart rate before the start of the second electroencephalography measurement. CONCLUSION: We identified Chronic effects of exercise training on the cortical activity of modern pentathlon athletes, read-through differences in absolute alpha power, and acute effects of a high-intensity exercise session for athletes and non-athletes for electrocortical and behavioral responses.</b>
DOI: 10.6084/m9.figshare.94357.v1
title: Bayesian model of the listener

description: This Bayesian network model of a listener is supplementary material to the following publication: Buschmeier, H. & Kopp, S. (2012). Using a Bayesian model of the listener to unveil the dialogue information state. In <em>SemDial 2012: Proceedings of the 16th Workshop on the Semantics and Pragmatics of Dialogue,</em> pp. 12–20, Paris, France. [download pdf]
DOI: 10.6084/m9.figshare.4240232.v1
title: Data for SBB1145R1, Bailey et al. 20XX.

description: Data, organized by figure/table number, used for analyses and for figures in manuscript 11452 submitted, accepted to Soil Biology and Biochemistry (SBB). Please note that data here is often in its original form and that statistical analyses were often performed on transformed data (transformed to meet assumptions of normality). Transformations are noted in methods and/or figure and table captions.
DOI: 10.6084/m9.figshare.19209846.v1
title: White Muscle Transcriptome & Annotation

description: White muscle transcriptome and annotation for lake sturgeon.