cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.29391881.v1
title: Supplementary Material for: Changes in the skin microbiome of a patient with head and neck cancer with severe radiodermatitis: A case report

description: Introduction: Identifying the skin microbiome associated with severe radiodermatitis could lead to the development of preventive care strategies and early healing interventions, which are currently lacking. In this study, we investigated changes in the skin microbiome of a patient with head and neck cancer who developed severe radiodermatitis from the initiation of radiation therapy to the resolution of dermatitis.
Case Presentation: An 82-year-old male underwent chemoradiotherapy with cisplatin (69.96 Gy/33 fractions) for recurrent laryngeal cancer after a total laryngectomy. At baseline, Cutibacterium accounted for 64.3% of the skin microbiome and Staphylococcus for 23.2%. During the occurrence of moist desquamation associated with severe radiodermatitis, Cutibacterium decreased sharply to 0.2%, whereas Staphylococcus increased to 91.0%. Species-level analysis revealed that Staphylococcus aureus was dominant at 50.6%, whereas Staphylococcus hominis and Staphylococcus epidermidis were identified at 0.4% and 1.7%, respectively.
Conclusion: These findings demonstrated that changes in the skin microbiome occur during the progression of severe radiodermatitis. The reduction in Cutibacterium and overgrowth of Staphylococcus, particularly Staphylococcus aureus, suggest their involvement in the development of severe radiodermatitis in patients with head and neck cancer.
DOI: 10.5281/zenodo.15730774
title: LEX v1.4 Data
DOI: 10.6084/m9.figshare.29391884
title: Supplementary Material for: Diverse Obesity Trajectories in a Family including Identical Twins with a Pathogenic MC4R Variant

description: Introduction: Pathogenic heterozygous melanocortin-4 receptor (MC4R) variants are the most common cause of monogenic obesity, affecting central satiety and appetite regulatory areas of the brain. Case Presentations: We report a pedigree with a pathogenic MC4R variant (c.380C&gt;T, p.Ser127Leu). In the proband with obesity (BMI 35 kg/m2) and severe insulin resistance, use of combination semaglutide and naltrexone-bupropion was successful in reducing insulin requirements and weight. His adult monozygotic twin daughters both had childhood-onset obesity, however weight trajectories differed. Twin 1 had a peak BMI of 29.1 kg/m2, which decreased to 19.7 kg/m2 with intensive exercise and diet control without weight-lowering medication. Twin 2 had a sedentary lifestyle and epilepsy and had a peak BMI of 30.1 kg/m2; she responded well to naltrexone-bupropion and BMI decreased to 26 kg/m2. Conclusion: The manifestation of obesity, even in cases of monogenic obesity, can vary significantly due to the influence of environmental and lifestyle factors.
DOI: 10.6084/m9.figshare.29391884.v1
title: Supplementary Material for: Diverse Obesity Trajectories in a Family including Identical Twins with a Pathogenic MC4R Variant

description: Introduction: Pathogenic heterozygous melanocortin-4 receptor (MC4R) variants are the most common cause of monogenic obesity, affecting central satiety and appetite regulatory areas of the brain. Case Presentations: We report a pedigree with a pathogenic MC4R variant (c.380C&gt;T, p.Ser127Leu). In the proband with obesity (BMI 35 kg/m2) and severe insulin resistance, use of combination semaglutide and naltrexone-bupropion was successful in reducing insulin requirements and weight. His adult monozygotic twin daughters both had childhood-onset obesity, however weight trajectories differed. Twin 1 had a peak BMI of 29.1 kg/m2, which decreased to 19.7 kg/m2 with intensive exercise and diet control without weight-lowering medication. Twin 2 had a sedentary lifestyle and epilepsy and had a peak BMI of 30.1 kg/m2; she responded well to naltrexone-bupropion and BMI decreased to 26 kg/m2. Conclusion: The manifestation of obesity, even in cases of monogenic obesity, can vary significantly due to the influence of environmental and lifestyle factors.
DOI: 10.3886/icpsr02670.v1
title: CBS News Call-Back Poll, November 1998
title: Version 1

description: This poll is part of a continuing series of monthly surveys
 that solicit public opinion on the presidency and on a range of other
 political and social issues. This survey, fielded November 19, 1998,
 is a call-back of the November 16-17, 1998, cohort (CBS NEWS MONTHLY
 POLL #2, NOVEMBER 1998 [ICPSR 2669]). Respondents were asked to give
 their opinions of President Bill Clinton, Vice President Al Gore,
 First Lady Hillary Clinton, Independent Counsel Kenneth Starr, and
 House of Representatives Judiciary Committee Chairman Henry
 Hyde. Respondents were also asked if they had viewed any of the
 televised House Judiciary Committee impeachment inquiry, which began
 earlier in the day. Those queried were asked for their views on Starr
 and his testimony, and whether they learned anything new from watching
 the inquiry. Respondents were asked whether they believed that
 Democrats and Republicans were capable of working together in a
 nonpartisan manner during the hearings, whether the inquiry was more
 about crime or about politics, and what the motives were behind the
 questioning. Views were also sought on which of the possible outcomes
 of the impeachment inquiry would be best for the country. Background
 information on respondents includes age, sex, race, education,
 religion, political party, political orientation, voter participation
 history, marital status, age of children in household, family income,
and computer access.
description: Datasets: 
DS1: CBS News Call-Back Poll, November 1998
description: This collection has not been processed by ICPSR
 staff. ICPSR is distributing the data and documentation for this
 collection in essentially the same form in which they were
 received. When appropriate, hardcopy documentation has been converted
 to machine-readable form and variables have been recoded to ensure
respondents' anonymity.
DOI: 10.3886/icpsr02670
title: CBS News Call-Back Poll, November 1998
title: Archival Version

description: This poll is part of a continuing series of monthly surveys
 that solicit public opinion on the presidency and on a range of other
 political and social issues. This survey, fielded November 19, 1998,
 is a call-back of the November 16-17, 1998, cohort (CBS NEWS MONTHLY
 POLL #2, NOVEMBER 1998 [ICPSR 2669]). Respondents were asked to give
 their opinions of President Bill Clinton, Vice President Al Gore,
 First Lady Hillary Clinton, Independent Counsel Kenneth Starr, and
 House of Representatives Judiciary Committee Chairman Henry
 Hyde. Respondents were also asked if they had viewed any of the
 televised House Judiciary Committee impeachment inquiry, which began
 earlier in the day. Those queried were asked for their views on Starr
 and his testimony, and whether they learned anything new from watching
 the inquiry. Respondents were asked whether they believed that
 Democrats and Republicans were capable of working together in a
 nonpartisan manner during the hearings, whether the inquiry was more
 about crime or about politics, and what the motives were behind the
 questioning. Views were also sought on which of the possible outcomes
 of the impeachment inquiry would be best for the country. Background
 information on respondents includes age, sex, race, education,
 religion, political party, political orientation, voter participation
 history, marital status, age of children in household, family income,
and computer access.
description: Datasets: 
DS1: CBS News Call-Back Poll, November 1998
description: This collection has not been processed by ICPSR
 staff. ICPSR is distributing the data and documentation for this
 collection in essentially the same form in which they were
 received. When appropriate, hardcopy documentation has been converted
 to machine-readable form and variables have been recoded to ensure
respondents' anonymity.
DOI: 10.6084/m9.figshare.29391887
title: Supplementary Material for: Rural-Urban Disparities in Acute Stroke Treatments and Outcomes: A Propensity Score-Matched Analysis of a Nationwide Sample.

description: Purpose
To investigate the rural-urban differences in acute stroke care in a large cohort of patients hospitalized for acute ischemic stroke (AIS), using a nationwide inpatient sample.

Methods
In this retrospective cohort study, the National Inpatient Sample database was investigated for patients admitted with AIS from 2016 to 2022. Socio-demographics and comorbidities were reviewed. Interventions (rtPA and thrombectomy) were investigated. Outcome measures were prolonged length of stay (PLOS) and mortality. PLOS was defined as length of stay exceeding the 75th percentile of the entire cohort. The cohort was divided in rural and urban location Propensity-score matching (PSM) was applied to balance demographics and comorbidities between the two groups, and outcomes were analyzed between the two matched groups. Multivariable logistic models were used to determine the association between each intervention and rural location. Risk ratio was calculated for PLOS and mortality. Subgroup analyses were performed by age, race, and income. P value as set at 0.05 for all analyses.

Results
Of 897,206 AIS patients, 64,640 (7.2%) were cared for in rural location. Rural group was older (74 [64-83] vs. 71 [60-81], p&lt;0.01) years. Rural group had higher rate of females (51.8% vs. 49%), white racial group (79.8% vs. 64.5%), lower median household income (54.3% vs. 29.1%), and lower private insurance (14.3% vs. 19.2%), p&lt;0.01 for all. After PSM 1:1, rural group independently retained lower odds of rtPA (OR: 0.532, 95%CI: 0.505 - 0.561), lower odds of thrombectomy (OR: 0.074, 95%CI: 0.061 – 0.089), lower risk of PLOS (RR: 0.887, 95%CI: 0.882 – 0.892) and higher risk of mortality (RR: 1.149, 95%CI: 1.122 – 1.177), p&lt;0.01 for all. Older patients in rural setting had lowest odds of interventions, whereas younger, Black, and Hispanic rural patients had highest risk of mortality after AIS. 

Conclusions
Socio-demographic differences are present between rural and urban acute stroke care. Profound inequalities exist in the use of reperfusion therapy and outcomes. Great effort is needed by the stroke community to fill this gap and provide equality in acute stroke care.
DOI: 10.6084/m9.figshare.29391887.v1
title: Supplementary Material for: Rural-Urban Disparities in Acute Stroke Treatments and Outcomes: A Propensity Score-Matched Analysis of a Nationwide Sample.

description: Purpose
To investigate the rural-urban differences in acute stroke care in a large cohort of patients hospitalized for acute ischemic stroke (AIS), using a nationwide inpatient sample.

Methods
In this retrospective cohort study, the National Inpatient Sample database was investigated for patients admitted with AIS from 2016 to 2022. Socio-demographics and comorbidities were reviewed. Interventions (rtPA and thrombectomy) were investigated. Outcome measures were prolonged length of stay (PLOS) and mortality. PLOS was defined as length of stay exceeding the 75th percentile of the entire cohort. The cohort was divided in rural and urban location Propensity-score matching (PSM) was applied to balance demographics and comorbidities between the two groups, and outcomes were analyzed between the two matched groups. Multivariable logistic models were used to determine the association between each intervention and rural location. Risk ratio was calculated for PLOS and mortality. Subgroup analyses were performed by age, race, and income. P value as set at 0.05 for all analyses.

Results
Of 897,206 AIS patients, 64,640 (7.2%) were cared for in rural location. Rural group was older (74 [64-83] vs. 71 [60-81], p&lt;0.01) years. Rural group had higher rate of females (51.8% vs. 49%), white racial group (79.8% vs. 64.5%), lower median household income (54.3% vs. 29.1%), and lower private insurance (14.3% vs. 19.2%), p&lt;0.01 for all. After PSM 1:1, rural group independently retained lower odds of rtPA (OR: 0.532, 95%CI: 0.505 - 0.561), lower odds of thrombectomy (OR: 0.074, 95%CI: 0.061 – 0.089), lower risk of PLOS (RR: 0.887, 95%CI: 0.882 – 0.892) and higher risk of mortality (RR: 1.149, 95%CI: 1.122 – 1.177), p&lt;0.01 for all. Older patients in rural setting had lowest odds of interventions, whereas younger, Black, and Hispanic rural patients had highest risk of mortality after AIS. 

Conclusions
Socio-demographic differences are present between rural and urban acute stroke care. Profound inequalities exist in the use of reperfusion therapy and outcomes. Great effort is needed by the stroke community to fill this gap and provide equality in acute stroke care.
DOI: 10.6084/m9.figshare.29391890
title: Supplementary Material for: The individual and interactive effects of alpha-pinene and delta-9-tetrahydrocannabinol (Δ9-THC) in healthy adults

description: Introduction. Cannabis contains hundreds of chemical constituents beyond delta-9-tetrahydrocannabinol (Δ9-THC), which is thought to be the primary driver of most of its acute pharmacodynamic effects. The entourage effect theory asserts that the pharmacological and therapeutic effects of cannabis are not solely attributable to Δ9-THC, but are influenced by other constituents, such as minor cannabinoids and terpenes, through distinct pharmacological action. However, empirical studies that have systematically evaluated this theory in humans remain limited. This study tested the hypothesis that the terpene α-pinene can attenuate the acute memory-impairing effects of inhaled Δ9-THC in humans.
Methods. Participants (N = 19; last cannabis use 39 days, on average, prior to first test session [SD = 84; range = 2–365]) completed six double-blind outpatient drug administration sessions during which they inhaled, using a Mighty Medic hand-held vaporizer, α-pinene alone (15 mg), Δ9-THC alone (30 mg), Δ9-THC and α-pinene together (30 mg Δ9-THC + 0.5 mg α-pinene; 30 mg Δ9-THC + 5 mg α-pinene; 30 mg Δ9-THC + 15 mg α-pinene), or placebo (ambient air) in a randomized order. Outcomes, which were collected up to 6 hours post drug exposure, included subjective drug effects, cognitive/psychomotor performance, and vital signs.
Results. Administration of 15 mg α-pinene alone produced no significant pharmacodynamic effects compared to placebo. Administration of 30 mg Δ9-THC alone elicited subjective, cognitive, and physiological effects consistent with acute Δ9-THC-dominant cannabis exposure, including impairment of cognitive performance and working memory ability compared to placebo. The co-administration of α-pinene with Δ9-THC did not mitigate Δ9-THC-induced memory impairment or significantly alter other acute subjective, cognitive, or physiological effects.
Conclusions. Inhaled α-pinene, at doses at and above those naturally found in cannabis flowers, did not mitigate Δ9-THC-induced cognitive impairments as hypothesized or influence other common acute effects of Δ9-THC in this sample of healthy adults. This result is inconsistent with some cannabis industry claims and speculation by some cannabis researchers. By systematically varying both Δ9-THC and terpene exposure and assessing their interaction across multiple pharmacodynamic domains, this work provides a model for future investigations into Δ9-THC-terpene interactions. As cannabis use continues to expand for both medicinal and non-medicinal purposes, more research is needed to better understand the acute effects of lesser studied chemical constituents of the plant and how they interact with predominant phytocannabinoids like Δ9-THC. This can inform cannabinoid drug development and product policy considerations.
DOI: 10.6084/m9.figshare.29391890.v1
title: Supplementary Material for: The individual and interactive effects of alpha-pinene and delta-9-tetrahydrocannabinol (Δ9-THC) in healthy adults

description: Introduction. Cannabis contains hundreds of chemical constituents beyond delta-9-tetrahydrocannabinol (Δ9-THC), which is thought to be the primary driver of most of its acute pharmacodynamic effects. The entourage effect theory asserts that the pharmacological and therapeutic effects of cannabis are not solely attributable to Δ9-THC, but are influenced by other constituents, such as minor cannabinoids and terpenes, through distinct pharmacological action. However, empirical studies that have systematically evaluated this theory in humans remain limited. This study tested the hypothesis that the terpene α-pinene can attenuate the acute memory-impairing effects of inhaled Δ9-THC in humans.
Methods. Participants (N = 19; last cannabis use 39 days, on average, prior to first test session [SD = 84; range = 2–365]) completed six double-blind outpatient drug administration sessions during which they inhaled, using a Mighty Medic hand-held vaporizer, α-pinene alone (15 mg), Δ9-THC alone (30 mg), Δ9-THC and α-pinene together (30 mg Δ9-THC + 0.5 mg α-pinene; 30 mg Δ9-THC + 5 mg α-pinene; 30 mg Δ9-THC + 15 mg α-pinene), or placebo (ambient air) in a randomized order. Outcomes, which were collected up to 6 hours post drug exposure, included subjective drug effects, cognitive/psychomotor performance, and vital signs.
Results. Administration of 15 mg α-pinene alone produced no significant pharmacodynamic effects compared to placebo. Administration of 30 mg Δ9-THC alone elicited subjective, cognitive, and physiological effects consistent with acute Δ9-THC-dominant cannabis exposure, including impairment of cognitive performance and working memory ability compared to placebo. The co-administration of α-pinene with Δ9-THC did not mitigate Δ9-THC-induced memory impairment or significantly alter other acute subjective, cognitive, or physiological effects.
Conclusions. Inhaled α-pinene, at doses at and above those naturally found in cannabis flowers, did not mitigate Δ9-THC-induced cognitive impairments as hypothesized or influence other common acute effects of Δ9-THC in this sample of healthy adults. This result is inconsistent with some cannabis industry claims and speculation by some cannabis researchers. By systematically varying both Δ9-THC and terpene exposure and assessing their interaction across multiple pharmacodynamic domains, this work provides a model for future investigations into Δ9-THC-terpene interactions. As cannabis use continues to expand for both medicinal and non-medicinal purposes, more research is needed to better understand the acute effects of lesser studied chemical constituents of the plant and how they interact with predominant phytocannabinoids like Δ9-THC. This can inform cannabinoid drug development and product policy considerations.
DOI: 10.6084/m9.figshare.29391893
title: Supplementary Material for: Adrenal Incidentaloma Masquerading as Malignancy: A Rare Case of Ganglioneuroma with Nodal Metastasis

description: Introduction: Adrenal ganglioneuromas are rare benign tumours, accounting for 0.3% to 2% of adrenal incidentalomas. They arise from Schwann and ganglion cells and often mimic adrenal cortical carcinoma clinically and radiologically. Despite their benign nature, metastatic deposits in lymph nodes have been reported, suggesting tumour maturation. Diagnosis is typically confirmed through postoperative histopathology.
Case Presentation: A male patient in his early 60s with a history of hypertension presented with an adrenal incidentaloma. Imaging revealed a well-defined, hypodense right adrenal mass (35 HU) with calcifications and an enlarged aortocaval lymph node, raising suspicion for carcinoma. Biochemical analysis showed a non-functional adrenal tumour. Intraoperatively, the mass appeared benign, but the lymph node deposit suggested malignancy. Histopathological examination confirmed right adrenal ganglioneuroma with metastatic deposits in the aortocaval lymph nodes. The patient recovered well postoperatively, with normal serum cortisol levels and no signs of recurrence at 6-month follow-up.
Conclusion: Adrenal ganglioneuromas can present as adrenal incidentalomas with lymph node involvement, mimicking malignancy. Surgery remains the gold standard for treatment, and postoperative histopathology is crucial for diagnosis. No adjuvant therapy or stringent follow-up is required after surgical removal in such cases.
DOI: 10.6084/m9.figshare.29391893.v1
title: Supplementary Material for: Adrenal Incidentaloma Masquerading as Malignancy: A Rare Case of Ganglioneuroma with Nodal Metastasis

description: Introduction: Adrenal ganglioneuromas are rare benign tumours, accounting for 0.3% to 2% of adrenal incidentalomas. They arise from Schwann and ganglion cells and often mimic adrenal cortical carcinoma clinically and radiologically. Despite their benign nature, metastatic deposits in lymph nodes have been reported, suggesting tumour maturation. Diagnosis is typically confirmed through postoperative histopathology.
Case Presentation: A male patient in his early 60s with a history of hypertension presented with an adrenal incidentaloma. Imaging revealed a well-defined, hypodense right adrenal mass (35 HU) with calcifications and an enlarged aortocaval lymph node, raising suspicion for carcinoma. Biochemical analysis showed a non-functional adrenal tumour. Intraoperatively, the mass appeared benign, but the lymph node deposit suggested malignancy. Histopathological examination confirmed right adrenal ganglioneuroma with metastatic deposits in the aortocaval lymph nodes. The patient recovered well postoperatively, with normal serum cortisol levels and no signs of recurrence at 6-month follow-up.
Conclusion: Adrenal ganglioneuromas can present as adrenal incidentalomas with lymph node involvement, mimicking malignancy. Surgery remains the gold standard for treatment, and postoperative histopathology is crucial for diagnosis. No adjuvant therapy or stringent follow-up is required after surgical removal in such cases.
DOI: 10.6084/m9.figshare.29391866.v1
title: Dataset for study on social media fit and use

description: social media use at work
DOI: 10.6084/m9.figshare.29391866
title: Dataset for study on social media fit and use

description: social media use at work