cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.9751325.v1
title: Additional file 10: of Combining next-generation sequencing and single-molecule sequencing to explore brown plant hopper responses to contrasting genotypes of japonica rice

description: Detection of fusion genes. Table S11. All detected fusion genesâ sequences. Table S12. Positions of 915 fusion genes. (XLSX 1247 kb)
DOI: 10.6084/m9.figshare.9751337
title: Additional file 11: of Combining next-generation sequencing and single-molecule sequencing to explore brown plant hopper responses to contrasting genotypes of japonica rice

description: Boundary sites of transcripts resulting from fusion of sequences of annotated genes at different locations. (XLSX 44 kb)
DOI: 10.6084/m9.figshare.9751337.v1
title: Additional file 11: of Combining next-generation sequencing and single-molecule sequencing to explore brown plant hopper responses to contrasting genotypes of japonica rice

description: Boundary sites of transcripts resulting from fusion of sequences of annotated genes at different locations. (XLSX 44 kb)
DOI: 10.6084/m9.figshare.9751343
title: Additional file 2: of Educational efficacy of high-fidelity simulation in neonatal resuscitation training: a systematic review and meta-analysis

description: Table S1. Details of the intervention of the included studies. (XLSX 14 kb)
DOI: 10.6084/m9.figshare.9751343.v1
title: Additional file 2: of Educational efficacy of high-fidelity simulation in neonatal resuscitation training: a systematic review and meta-analysis

description: Table S1. Details of the intervention of the included studies. (XLSX 14 kb)
DOI: 10.6084/m9.figshare.20237112
title: Migration and tectonic implications of Late Jurassic mafic magmatism in South China

description: Table S3. LA-ICP-MS U-Pb analyses for zircons for mafic rocks in the south-eastern SCB
DOI: 10.6084/m9.figshare.20237112.v1
title: Migration and tectonic implications of Late Jurassic mafic magmatism in South China

description: Table S3. LA-ICP-MS U-Pb analyses for zircons for mafic rocks in the south-eastern SCB
DOI: 10.6084/m9.figshare.17091387
title: Blood-based traumatic brain injury biomarkers – Clinical utilities and regulatory pathways in the United States, Europe and Canada

description: Traumatic brain injury (TBI) is a major global health issue, resulting in debilitating consequences to families, communities, and health-care systems. Prior research has found that biomarkers aid in the pathophysiological characterization and diagnosis of TBI. Significantly, the FDA has recently cleared both a bench-top assay and a rapid point-of-care assays of tandem biomarker (UCH-L1/GFAP)-based blood test to aid in the diagnosis mTBI patients. With the global necessity of TBI biomarkers research, several major consortium multicenter observational studies with biosample collection and biomarker analysis have been created in the USA, Europe, and Canada. As each geographical region regulates its data and findings, the International Initiative for Traumatic Brain Injury Research (InTBIR) was formed to facilitate data integration and dissemination across these consortia. This paper covers heavily investigated TBI biomarkers and emerging non-protein markers. Finally, we analyze the regulatory pathways for converting promising TBI biomarkers into approved <i>in-vitro</i> diagnostic tests in the United States, European Union, and Canada. TBI biomarker research has significantly advanced in the last decade. The recent approval of an iSTAT point of care test to detect mild TBI has paved the way for future biomarker clearance and appropriate clinical use across the globe.
DOI: 10.6084/m9.figshare.20236151.v1
title: Additional file 1 of Integrated analysis reveals the dysfunction of signaling pathways in uveal melanoma

description: Additional file 1: Table_S1. Summary information for the 4 original scRNA-seq datasets and integrated dataset
DOI: 10.6084/m9.figshare.20236154.v1
title: Additional file 2 of Integrated analysis reveals the dysfunction of signaling pathways in uveal melanoma

description: Additional file 2: Table_S2. Clinical information and gene-expression profile of the three primary uveal melanomas
DOI: 10.6084/m9.figshare.20237115
title: Migration and tectonic implications of Late Jurassic mafic magmatism in South China

description: Table S2. Whole-rock major oxides, trace elemental, and Sr-Nd-Pb isotopic analysed results for the representative mafic rocks in SE South China Block (SCB)
DOI: 10.6084/m9.figshare.20237115.v1
title: Migration and tectonic implications of Late Jurassic mafic magmatism in South China

description: Table S2. Whole-rock major oxides, trace elemental, and Sr-Nd-Pb isotopic analysed results for the representative mafic rocks in SE South China Block (SCB)
DOI: 10.6084/m9.figshare.14993014
title: Additional file 6 of Global analysis of protein lysine 2-hydroxyisobutyrylation (Khib) profiles in Chinese herb rhubarb (Dahuang)

description: Table S5, KEGG pathway enrichment analysis of Khib-modified proteins.
DOI: 10.6084/m9.figshare.20236163
title: Additional file 5 of Integrated analysis reveals the dysfunction of signaling pathways in uveal melanoma

description: Additional file 5: Table_S5. Differentially expressed genes in TCGA data_UVM
DOI: 10.6084/m9.figshare.20237118
title: Migration and tectonic implications of Late Jurassic mafic magmatism in South China

description: Table S4. Zircon in-situ Hf isotopic analytical results for the representative mafic rocks in the south-eastern SCB
DOI: 10.6084/m9.figshare.14993661.v1
title: Datafile S5. from Multicellularity and sex helped shape the Tree of Life

description: Summary data for 17 kingdom-level clades based on described species richness.
DOI: 10.6084/m9.figshare.20237118.v1
title: Migration and tectonic implications of Late Jurassic mafic magmatism in South China

description: Table S4. Zircon in-situ Hf isotopic analytical results for the representative mafic rocks in the south-eastern SCB
DOI: 10.6084/m9.figshare.13420718
title: <i>Phlebopus roseus</i>, a new edible bolete from China, is associated with insects and plants

description: <i>Phlebopus roseus</i> is described as new based on collections from southwest China. Phylogenetic analyses of nuclear rDNA internal transcribed spacer region ITS1-5.8S-ITS2 (ITS) and portions of nuclear 28S rDNA (28S), translation elongation factor 1-alpha (<i>tef1</i>), and the largest and second largest subunits of RNA polymerase II (<i>rpb1, rpb2</i>) support <i>P. roseus</i> as a novel species in the genus <i>Phlebopus</i> (Boletinellaceae, Boletales). The new species resembles <i>P. portentosus</i> but differs from it in that mature basidiomata have a bright rose-red-colored stipe and a radiate tubular hymenophore with nested pores. Despite extensive searching, <i>P. roseus</i> has only been found at four sites within a 24-hectare orchard dominated by <i>Eriobotrya japonica</i>, which is agriculturally important given its fruit production (loquats). Therefore, this species appears to be endemic and geographically restricted. The ecology of this bolete is also unique. In line with the trophic behavior of other species in the Boletinellaceae, our observations indicate that <i>P. roseus</i> forms a symbiotic association with the scale insect <i>Coccus hesperidum</i>, identified through sequence analysis of its mitochondrial cytochrome <i>c</i> oxidase subunit I (<i>COI</i>) region, to form fungus-insect galls that develop on roots of <i>E. japonica</i> trees. <i>Phlebopus roseus</i> is an edible mushroom species and is collected from the type location by farmers and sold commercially in limited quantities at local markets alongside <i>P. portentosus</i> and other fungi.
DOI: 10.6084/m9.figshare.14993014.v1
title: Additional file 6 of Global analysis of protein lysine 2-hydroxyisobutyrylation (Khib) profiles in Chinese herb rhubarb (Dahuang)

description: Table S5, KEGG pathway enrichment analysis of Khib-modified proteins.
DOI: 10.5281/zenodo.10670564
title: A Systematic Mapping Study on Software Containers Risks and Vulnerabilities-Venues Published on Container Risks and Vulnerabilities
DOI: 10.5281/zenodo.10670565
title: A Systematic Mapping Study on Software Containers Risks and Vulnerabilities-Venues Published on Container Risks and Vulnerabilities
DOI: 10.5281/zenodo.7866632
title: Medical Device Industry Payments Europe 2017-2019

description: Data on education payments from medical device companies who are members of MedTech Europe. Data is aggregated by year/company/country. Source: transparentmedtech.eu
DOI: 10.5281/zenodo.10668704
title: Initial and final states of Molecular Dynamics for "The binding and mechanism of a positive allosteric modulator of Kv3 channels"

description: Initial and final structures for molecular dynamics for three systems: wildtype, S4R/A5G/S6N mutation and 3.1x3.4 turret exchange.
description: The work was supported by National Council for Scientific and Technological Development CNPq [grant number 302089/2019-5 and 200114/2020-4 (WT)], Coordenação de Aperfeiçoamento de Pessoal de Nível Superior CAPES [grant number 23038.010052/2013-95 (WT)], and Fundação de Apoio a Pesquisa do Distrito Federal FAPDF [grant number 193.001.202/2016 (WT)].
DOI: 10.5281/zenodo.10668705
title: Initial and final states of Molecular Dynamics for "The binding and mechanism of a positive allosteric modulator of Kv3 channels"

description: Initial and final structures for molecular dynamics for three systems: wildtype, S4R/A5G/S6N mutation and 3.1x3.4 turret exchange.
description: The work was supported by National Council for Scientific and Technological Development CNPq [grant number 302089/2019-5 and 200114/2020-4 (WT)], Coordenação de Aperfeiçoamento de Pessoal de Nível Superior CAPES [grant number 23038.010052/2013-95 (WT)], and Fundação de Apoio a Pesquisa do Distrito Federal FAPDF [grant number 193.001.202/2016 (WT)].
DOI: 10.6084/m9.figshare.14993646.v1
title: Datafile S9. from Multicellularity and sex helped shape the Tree of Life

description: Summary data for 17 kingdom-level clades based on high projected species numbers
DOI: 10.6084/m9.figshare.14993652.v1
title: Datafile S8. from Multicellularity and sex helped shape the Tree of Life

description: Summary data for 17 kingdom-level clades based on low projected species numbers
DOI: 10.6084/m9.figshare.21285416
title: Efficacy and safety of liraglutide for obesity and people who are overweight: a systematic review and meta-analysis of randomized controlled trials

description: As the pandemic of obesity presents an increasing serious health challenge worldwide, additional medical interventions, especially pharmacotherapy, should be addressed for the affected people. Liraglutide 3.0 mg, is one of the possible options for long-term anti-obesity treatment. We systematically searched the databases of PubMed, Embase, Cochrane Central Register of Controlled Trials, and ClinicalTrials.gov. A meta-analysis was then performed using random-effect models. Meta-analyses of seven phase 3 and 4 RCTs (<i>N</i> = 6,028), which were conducted in adults with obesity or overweight for at least 1 year, demonstrated a significant weight reduction with liraglutide 3.0 mg (mean difference of percentage weight change −4.81%; 95% CI: −5.56% to −4.06%; <i>P</i> &lt; 0.00001), relative to placebo. However, more participants taking liraglutide experienced at least one adverse event. More discontinuations due to adverse events were observed among them. In the subgroup analysis among participants with or without diabetes mellitus (DM), pooled result showed that liraglutide was associated with a greater decrease in the percentage of weight change in participants without DM. This study provided support for the use of liraglutide 3.0 mg for weight management in adults with obesity or who are overweight.
DOI: 10.6084/m9.figshare.14993667.v1
title: Datafile S10. from Multicellularity and sex helped shape the Tree of Life

description: Summary data for 31 clades
DOI: 10.6084/m9.figshare.14993655.v1
title: Datafile S6. from Multicellularity and sex helped shape the Tree of Life

description: Tree for 31 clades
DOI: 10.6084/m9.figshare.14993670.v1
title: Datafile S7. from Multicellularity and sex helped shape the Tree of Life

description: Tree for 15 kingdom-level eukaryote clades
DOI: 10.6084/m9.figshare.14993658.v1
title: Datafile S2. from Multicellularity and sex helped shape the Tree of Life

description: Data on multicellularity and sexual reproduction within 15 kingdom-level clades
DOI: 10.6084/m9.figshare.20236844
title: Raw data from Transformation to ischemia tolerance of frog brain function corresponds with dynamic changes in mRNA co-expression across metabolic pathways

description: File contains the dataset generated in the study that led to the production of the figures presented.
DOI: 10.6084/m9.figshare.14993002.v1
title: Additional file 2 of Global analysis of protein lysine 2-hydroxyisobutyrylation (Khib) profiles in Chinese herb rhubarb (Dahuang)

description: Table S1, All identified Khib-modified peptides and proteins in rhubarb.
DOI: 10.6084/m9.figshare.14993005
title: Additional file 3 of Global analysis of protein lysine 2-hydroxyisobutyrylation (Khib) profiles in Chinese herb rhubarb (Dahuang)

description: Table S2, GO functional classification of Khib-modified proteins.
DOI: 10.6084/m9.figshare.14993011
title: Additional file 5 of Global analysis of protein lysine 2-hydroxyisobutyrylation (Khib) profiles in Chinese herb rhubarb (Dahuang)

description: Table S4, GO enrichment analysis of Khib-modified proteins.
DOI: 10.6084/m9.figshare.14993011.v1
title: Additional file 5 of Global analysis of protein lysine 2-hydroxyisobutyrylation (Khib) profiles in Chinese herb rhubarb (Dahuang)

description: Table S4, GO enrichment analysis of Khib-modified proteins.
DOI: 10.6084/m9.figshare.14993017.v1
title: Additional file 7 of Global analysis of protein lysine 2-hydroxyisobutyrylation (Khib) profiles in Chinese herb rhubarb (Dahuang)

description: Table S6, Protein domain enrichment analysis of Khib-modified proteins
DOI: 10.6084/m9.figshare.14993664.v1
title: Datafile S1. from Multicellularity and sex helped shape the Tree of Life

description: Tree for 17 kingdom-level clades
DOI: 10.6084/m9.figshare.9751382
title: Additional file 17: of Combining next-generation sequencing and single-molecule sequencing to explore brown plant hopper responses to contrasting genotypes of japonica rice

description: All 1893 DEGs between N-BPH and NB6-BPH. Table S13. DEGs up-regulated in NB6-BPH relative to N-BPH. Table S14. DEGs down-regulated in NB6-BPH relative to N-BPH. (XLSX 265 kb)
DOI: 10.6084/m9.figshare.9751382.v1
title: Additional file 17: of Combining next-generation sequencing and single-molecule sequencing to explore brown plant hopper responses to contrasting genotypes of japonica rice

description: All 1893 DEGs between N-BPH and NB6-BPH. Table S13. DEGs up-regulated in NB6-BPH relative to N-BPH. Table S14. DEGs down-regulated in NB6-BPH relative to N-BPH. (XLSX 265 kb)
DOI: 10.6084/m9.figshare.9751388
title: Additional file 18: of Combining next-generation sequencing and single-molecule sequencing to explore brown plant hopper responses to contrasting genotypes of japonica rice

description: GO enrichment of DEGs between N-BPH and NB6-BPH. Table S15. GO enrichment of DEGs up-regulated in NB6-BPH relative to N-BPH. Table S16. GO enrichment of DEGs down-regulated in NB6-BPH relative to N-BPH. (XLSX 27 kb)
DOI: 10.6084/m9.figshare.9751388.v1
title: Additional file 18: of Combining next-generation sequencing and single-molecule sequencing to explore brown plant hopper responses to contrasting genotypes of japonica rice

description: GO enrichment of DEGs between N-BPH and NB6-BPH. Table S15. GO enrichment of DEGs up-regulated in NB6-BPH relative to N-BPH. Table S16. GO enrichment of DEGs down-regulated in NB6-BPH relative to N-BPH. (XLSX 27 kb)
DOI: 10.6084/m9.figshare.14993673.v1
title: Datafile S3. from Multicellularity and sex helped shape the Tree of Life

description: Estimated frequencies of multicellularity and sexual reproduction within phyla.
DOI: 10.6084/m9.figshare.24431459
title: Desmethoxycurcumin aids IFNα’s anti-HBV activity by antagonising CRYAB reduction and stabilising IFNAR1 protein

description: The eradication of chronic hepatitis B (CHB) caused by hepatitis B virus (HBV) infection is a crucial goal in clinical practice. Enhancing the anti-HBV activity of interferon type I (IFNI) is a key strategy for achieving a functional cure for CHB. In this study, we investigated the effect of combined treatment with IFNα and Desmethoxycurcumin (DMC) on HBV replication in HepG2 cells and explored the underlying mechanism. Our results indicated IFNα alone was ineffective in completely inhibiting HBV replication, which was attributed to the virus-induced down-regulation of IFNI receptor 1 (IFNAR1) protein. However, the addition of a low dose of DMC significantly synergized with IFNα, leading to notable enhancement of IFNα anti-HBV activity. This effect was achieved by stabilising the IFNAR1 protein. Further investigation revealed that low dose DMC effectively blocked the ubiquitination-mediated degradation of IFNAR1, which was accomplished by rescuing the protein levels of alphaB-crystallin (CRYAB) and orchestrating the interaction between CRYAB and the E3 ubiquitin ligase, β-Trcp. Importantly, over-expression of CRYAB was found to favour the antiviral activity of IFNα against HBV replication. In conclusion, our study demonstrates that low-dose DMC enhanced the anti-HBV activity of IFNα by counteracting the reduction of CRYAB and stabilising the IFNAR1 protein.
DOI: 10.6084/m9.figshare.24431459.v1
title: Desmethoxycurcumin aids IFNα’s anti-HBV activity by antagonising CRYAB reduction and stabilising IFNAR1 protein

description: The eradication of chronic hepatitis B (CHB) caused by hepatitis B virus (HBV) infection is a crucial goal in clinical practice. Enhancing the anti-HBV activity of interferon type I (IFNI) is a key strategy for achieving a functional cure for CHB. In this study, we investigated the effect of combined treatment with IFNα and Desmethoxycurcumin (DMC) on HBV replication in HepG2 cells and explored the underlying mechanism. Our results indicated IFNα alone was ineffective in completely inhibiting HBV replication, which was attributed to the virus-induced down-regulation of IFNI receptor 1 (IFNAR1) protein. However, the addition of a low dose of DMC significantly synergized with IFNα, leading to notable enhancement of IFNα anti-HBV activity. This effect was achieved by stabilising the IFNAR1 protein. Further investigation revealed that low dose DMC effectively blocked the ubiquitination-mediated degradation of IFNAR1, which was accomplished by rescuing the protein levels of alphaB-crystallin (CRYAB) and orchestrating the interaction between CRYAB and the E3 ubiquitin ligase, β-Trcp. Importantly, over-expression of CRYAB was found to favour the antiviral activity of IFNα against HBV replication. In conclusion, our study demonstrates that low-dose DMC enhanced the anti-HBV activity of IFNα by counteracting the reduction of CRYAB and stabilising the IFNAR1 protein.
DOI: 10.6084/m9.figshare.9751403
title: Additional file 19: of Combining next-generation sequencing and single-molecule sequencing to explore brown plant hopper responses to contrasting genotypes of japonica rice

description: KEGG enrichment of DEGs between N-BPH and NB6-BPH. Table S17. KEGG enrichment of DEGs up-regulated in NB6-BPH relative to N-BPH. Table S18. KEGG enrichment of DEGs down-regulated in NB6-BPH relative to N-BPH. (XLSX 16 kb)
DOI: 10.6084/m9.figshare.9751403.v1
title: Additional file 19: of Combining next-generation sequencing and single-molecule sequencing to explore brown plant hopper responses to contrasting genotypes of japonica rice

description: KEGG enrichment of DEGs between N-BPH and NB6-BPH. Table S17. KEGG enrichment of DEGs up-regulated in NB6-BPH relative to N-BPH. Table S18. KEGG enrichment of DEGs down-regulated in NB6-BPH relative to N-BPH. (XLSX 16 kb)
DOI: 10.6084/m9.figshare.9751418
title: Additional file 2: of Combining next-generation sequencing and single-molecule sequencing to explore brown plant hopper responses to contrasting genotypes of japonica rice

description: Table S1. Optimization of sequencesâ structure. (XLSX 1879 kb)
DOI: 10.6084/m9.figshare.9751418.v1
title: Additional file 2: of Combining next-generation sequencing and single-molecule sequencing to explore brown plant hopper responses to contrasting genotypes of japonica rice

description: Table S1. Optimization of sequencesâ structure. (XLSX 1879 kb)
DOI: 10.6084/m9.figshare.9751427
title: Additional file 4: of Combining next-generation sequencing and single-molecule sequencing to explore brown plant hopper responses to contrasting genotypes of japonica rice

description: Table S3. Intron boundary sequences at 5â ˛ and 3â ˛ ends in the BPH genome. (XLSX 15 kb)
DOI: 10.6084/m9.figshare.9751427.v1
title: Additional file 4: of Combining next-generation sequencing and single-molecule sequencing to explore brown plant hopper responses to contrasting genotypes of japonica rice

description: Table S3. Intron boundary sequences at 5â ˛ and 3â ˛ ends in the BPH genome. (XLSX 15 kb)
DOI: 10.6084/m9.figshare.9751430
title: Additional file 5: of Combining next-generation sequencing and single-molecule sequencing to explore brown plant hopper responses to contrasting genotypes of japonica rice

description: Table S4. Alternative splicing events detected in female adults of BPH biotype 1. (XLSX 1015 kb)
DOI: 10.6084/m9.figshare.9751430.v1
title: Additional file 5: of Combining next-generation sequencing and single-molecule sequencing to explore brown plant hopper responses to contrasting genotypes of japonica rice

description: Table S4. Alternative splicing events detected in female adults of BPH biotype 1. (XLSX 1015 kb)
DOI: 10.5281/zenodo.10653711
title: Medical Device Industry Payments Europe 2017-2019

description: Data on education payments from medical device companies who are members of MedTech Europe. Data is aggregated by year/company/country. Source: transparentmedtech.eu
DOI: 10.5281/zenodo.7866631
title: Medical Device Industry Payments Europe 2017-2019

description: Data on education payments from medical device companies who are members of MedTech Europe. Data is aggregated by year/company/country. Source: transparentmedtech.eu
DOI: 10.6084/m9.figshare.9751439
title: Additional file 7: of Combining next-generation sequencing and single-molecule sequencing to explore brown plant hopper responses to contrasting genotypes of japonica rice

description: Long non-coding RNA identification. Tables S6â S8: All 2435 predicted long non-coding RNA sequences, 168 known long non-coding RNA sequences, and 2267 novel long non-coding RNA sequences. (XLSX 3777 kb)
DOI: 10.6084/m9.figshare.9751439.v1
title: Additional file 7: of Combining next-generation sequencing and single-molecule sequencing to explore brown plant hopper responses to contrasting genotypes of japonica rice

description: Long non-coding RNA identification. Tables S6â S8: All 2435 predicted long non-coding RNA sequences, 168 known long non-coding RNA sequences, and 2267 novel long non-coding RNA sequences. (XLSX 3777 kb)
DOI: 10.6084/m9.figshare.7654289
title: Additional file 3: of Physiological and iTRAQ-based proteomic analyses reveal the function of exogenous γ-aminobutyric acid (GABA) in improving tea plant (Camellia sinensis L.) tolerance at cold temperature

description: Table S3: Functional classifications of identified proteins significantly expressed in leaves of tea plants exposed to the treatments T4/T3 for 7 days (4 °C and 4 °C + GABA for T3 and T4, respectively). Each value represents the average of three biological replicates. The average is significant at a p &lt; 0.01 level. A t-test value &lt; 0.05 is considered to be significant between treatment T4 and T3. (XLSX 47 kb)