cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.22225475
title: Association between Plasma Big Endothelin-1 Level and The Severity of Coronary Artery Disease in Patients with Non-ST Segment-Elevated Myocardial Infarction

description: Abstract Background Early risk stratification with simple biomarkers is essential in patients with non-ST segment-elevation myocardial infarction (NSTEMI). Objective This study aimed to evaluate the association between plasma big endothelin-1 (ET-1) level and the SYNTAX score (SS) in patients with NSTEMI. Methods A total of 766 patients with NSTEMI undergoing coronary angiography were recruited. Patients were divided into three groups: low SS (≤22), intermediate SS (23-32), and high SS (&gt;32). Spearman correlation, smooth curve fitting, logistic regression, and receiver operating characteristic (ROC) curve analysis were performed to evaluate the association between plasma big ET-1 level and the SS. A p-value &lt;0.05 was considered statistically significant. Results There was a significant correlation between the big ET-1 and the SS (r=0.378, p&lt;0.001). The smoothing curve indicated a positive correlation between the plasma big ET-1 level and the SS. The ROC curve analysis showed that the area under the curve was 0.695 (0.661-0.727) and the optimal cutoff of plasma big ET-1 level was 0.35pmol/l. Logistic regression showed that elevated big ET-1 was an independent predictor of intermediate-high SS in patients with NSTEMI, whether entered as a continuous variable [OR (95% CI): 1.110 (1.053-1.170), p&lt;0.001] or as a categorical variable [OR (95% CI): 2.962 (2.073-4.233), p&lt;0.001]. Conclusion In patients with NSTEMI, the plasma big ET-1 level was significantly correlated with the SS. Elevated plasma big ET-1 level was an independent predictor for intermediate-high SS.
DOI: 10.6084/m9.figshare.7021040.v1
title: Additional file 5: of The c-Myc-regulated lncRNA NEAT1 and paraspeckles modulate imatinib-induced apoptosis in CML cells

description: Table S3. Pathway analysis of genes regulated by SFPQ upon IM treatment. (XLSX 54 kb)
DOI: 10.6084/m9.figshare.21176069
title: Additional file 3 of DNA methylation underpins the epigenomic landscape regulating genome transcription in Arabidopsis

description: Additional file 3: Table S2. List of upregulated Tes with gain of active marks in ddcc, met1, and mddcc mutants.
DOI: 10.6084/m9.figshare.23797415.v1
title: Additional file 6 of Peptide aptamer-based time-resolved fluoroimmunoassay for CHIKV diagnosis

description: Supplementary Material 6
DOI: 10.6084/m9.figshare.23273265
title: Additional file 2 of Effect of miR-149-5p on intramuscular fat deposition in pigs based on metabolomics and transcriptomics

description: Additional file 2.
DOI: 10.6084/m9.figshare.23273268
title: Additional file 3 of Effect of miR-149-5p on intramuscular fat deposition in pigs based on metabolomics and transcriptomics

description: Additional file 3.
DOI: 10.6084/m9.figshare.9118373
title: Estimating Time-Varying Graphical Models

description: In this article, we study time-varying graphical models based on data measured over a temporal grid. Such models are motivated by the needs to describe and understand evolving interacting relationships among a set of random variables in many real applications, for instance, the study of how stock prices interact with each other and how such interactions change over time. We propose a new model, <i>LOcal Group Graphical Lasso Estimation</i> (loggle), under the assumption that the graph topology changes gradually over time. Specifically, loggle uses a novel local group-lasso type penalty to efficiently incorporate information from neighboring time points and to impose structural smoothness of the graphs. We implement an ADMM-based algorithm to fit the loggle model. This algorithm utilizes blockwise fast computation and pseudo-likelihood approximation to improve computational efficiency. An R package loggle has also been developed and is available at https://cran.r-project.org/. We evaluate the performance of loggle by simulation experiments. We also apply loggle to S&P 500 stock price data and demonstrate that loggle is able to reveal the interacting relationships among stock prices and among industrial sectors in a time period that covers the recent global financial crisis. The supplemental materials for this article are available online.
DOI: 10.6084/m9.figshare.11920338.v1
title: GR-mediated FTO transactivation induces lipid accumulation in hepatocytes via demethylation of m<sup>6</sup>A on lipogenic mRNAs

description: Chronic stress or excessive exposure to glucocorticoids (GC) contributes to the pathogenesis of non-alcoholic fatty liver disease (NAFLD). Glucocorticoid receptor (GR) mediates the action of GC, but its downstream signalling is not fully understood. Fat mass and obesity associated (FTO) protein and its demethylation substrate N6-methyladenosine (m<sup>6</sup>A) are both reported to participate in the regulation of lipid metabolism, yet it remains unknown whether they are involved in GC-induced hepatic lipid accumulation as new components of GR signalling. In this study, we use both in vivo and in vitro models of GC-induced hepatic lipid accumulation and demonstrate that the activation of lipogenic genes and accumulation of lipid in liver cells are mediated by GR-dependent FTO transactivation and m<sup>6</sup>A demethylation on mRNA of lipogenic genes. Targeted mutation of m<sup>6</sup>A methylation sites and FTO knockdown further validated the role of m<sup>6</sup>A on 3ʹUTR of sterol regulatory element-binding transcription factor 1 and stearoyl-CoA desaturase mRNAs. Finally, FTO knockdown significantly alleviated dexamethasone-induced fatty liver in mice. These results demonstrate a role of GR-mediated FTO transactivation and m<sup>6</sup>A demethylation in the pathogenesis of NAFLD and provide new insight into GR signalling in the regulation of fat metablism in the liver.
DOI: 10.6084/m9.figshare.12264122.v1
title: Synthesis and fungicidal activity of phenazine-1-carboxylic triazole derivatives

description: A total of 15 novel-substituted 3-(benzylsulfanyl)-1H-1,2,4-triazol-5-ylamine and 10 novel-substituted 3-benzylmercapto-1,2,4-triazol derivatives were synthesized based on the natural product phenazine-1-carboxylic acid (PCA). Their structures were confirmed by <sup>1</sup>H-NMR, <sup>13</sup>C-NMR, HRMS, and X-ray. Most substituted 3-benzylmercapto-1,2,4-triazol derivatives displayed very strong fungicidal activity against one or multiple plant pathogens <i>in vitro</i> and <i>in vivo</i>. Compounds <b>8b</b>, <b>8h</b>, and <b>8i</b> showed a broad spectrum of fungicidal activity. Further field experiments indicated that compounds <b>8b</b>, <b>8c</b>, and <b>8h</b> displayed better efficacy against rice blast (<i>Pyricularia oryzae</i>) than PCA. These data demonstrate that compounds <b>8b</b>, <b>8c,</b> and <b>8h</b> are promising fungicidal candidates, deserving further studies.
DOI: 10.6084/m9.figshare.20652759
title: Additional file 1 of Treatment of ankylosing spondylitis complicated with a thoracolumbar Andersson lesion by posterior closed osteotomy, debridement and fusion through the fracture line

description: Additional file 1: Supplementary Table 1. Basic information and original data of 13 patients.
DOI: 10.6084/m9.figshare.12788439
title: Additional file 4 of Prognostic value of a five-lncRNA signature in esophageal squamous cell carcinoma

description: Additional file 4: Table S3. The 1023 signatures comprising lncRNAs in the GSE53624 dataset (n = 119)
DOI: 10.6084/m9.figshare.12788698
title: Additional file 4 of Genome-wide pQTL analysis of protein expression regulatory networks in the human liver

description: Additional file 4: Data file S2. pQTL variants discovered in the human livers.
DOI: 10.6084/m9.figshare.12788487.v1
title: Additional file 3 of Genomics-assisted prediction of salt and alkali tolerances and functional marker development in apple rootstocks

description: Additional file 3: Supplementary Table S1. The phenotype data of alkali injury index (AID) of hybrids derived from ‘Baleng Crab’ (Malus robusta) × ‘M9’ (M. pumila) in 2015–2017. Supplementary Table S2. The phenotype data of salt injury index (SID) of hybrids derived from ‘Baleng Crab’ (Malus robusta) × ‘M9’ (M. pumila) in 2015–2017. Supplementary Table S3. The phenotype data of salt-alkali injury index (SAID) of hybrids derived from ‘Baleng Crab’ (Malus robusta) × ‘M9’ (M. pumila) in 2016–2017. Supplementary Table S4. Phenotypes of extremity segregant bulks for injury indices of salt, alkali, and salt-alkali in hybrids derived from ‘Baleng Crab’ (Malus robusta) × ‘M9’ (M. pumila) Supplementary Table S5. Summary of the BSA-seq data in extremity bulks of tolerant and sensitive using hybrids derived from ‘Baleng Crab’ (Malus robusta) × ‘M9’ (M. pumila). Supplementary Table S6. Summary of QTLs for injury indices of salt, alkali, and salt-alkali identified via BSA-seq in hybrid population from ‘Baleng Crab’ (Malus robusta) × ‘M9’ (M. pumila). Supplementary Table S7. Candidate genes for salt, alkali, and salt-alkali tolerance screened by parental re-sequencing, BSA-seq, and RNA-seq in a hybrid population from ‘Baleng Crab’ (Malus robusta) × ‘M9’ (M. pumila). Supplementary Table S8. Summary of candidate genes for salt, alkali, and salt-alkali tolerance screened by parental re-sequencing, BSA-seq, and RNA-seq in a hybrid population from ‘Baleng Crab’ (Malus robusta) × ‘M9’ (M. pumila). Supplementary Table S9. samples of root tissue for RNA-seq taken from salt, alkali, and salt-alkali treated hybrids from ‘Baleng Crab’ (Malus robusta) × ‘M9’ (M. pumila). Supplementary Table S10. Summary of the sequencing reads and reads mapping in RNA-seq.
DOI: 10.6084/m9.figshare.21176030
title: Additional file 1 of Combining single-cell RNA sequencing of peripheral blood mononuclear cells and exosomal transcriptome to reveal the cellular and genetic profiles in COPD

description: Additional file 1: Table S1. The expression matrix of exosomal RNA sequencing.
DOI: 10.6084/m9.figshare.7545947.v1
title: Additional file 1: of Global status of 47 major wheat loci controlling yield, quality, adaptation and stress resistance selected over the last century

description: Table S1. Detailed information on materials and their allelic variations of 47 genes used in this study. Table S2. Basic information including allelic variations and primer sequences for the 52 KASP assays. Table S3. Basic descriptive statistics in Chinese landraces (CL) and modern Chinese cultivars (MCC) for eleven traits using BLUP values. Table S4. Putative selective genes during wheat improvement based on the BLUP values of phenotypic traits. Table S5. Genome-wide association signals of 47 genes controlling adaptation and yield-related traits. (XLS 1118 kb)
DOI: 10.6084/m9.figshare.21701698
title: Depletion of circPDSS1 inhibits ITGA11 production to confer cisplatin sensitivity through miR-515-5p in gastric cancer

description: Chemoresistance limits cisplatin (DDP)-mediated treatment for gastric cancer (GC). Circular RNA (circRNA) acts an important role in chemoresistance. However, the underlying mechanism of circPDSS1 regulating DDP sensitivity in GC remains unclear. The expression patterns of circPDSS1, miR-515-5p and integrin subunit alpha 11 (ITGA11) were analyzed by qRT-PCR. Protein expression was checked by Western blotting analysis. Cell viability was investigated by 3-(4,5-dimethylthazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Cell proliferation was evaluated by colony formation assay and 5-ethynyl-2′-deoxyuridine (EdU) assay. The analysis of cell apoptosis, migration and invasion was performed by flow cytometry analysis and transwell assays. Dual-luciferase reporter assay and RNA immunoprecipitation assay were conducted to identify the associations among circPDSS1, miR-515-5p and ITGA11. <i>In vivo</i> assay was implemented using a xenograft mouse model assay. CircPDSS1 and ITGA11 expression were significantly upregulated, whereas miR-515-5p was downregulated in DDP-resistant GC tissues and cells in comparison with controls. CircPDSS1 depletion reduced DDP resistance, cell proliferation, migration and invasion but induced cell apoptosis in DDP-resistant GC cells. CircPDSS1 directly bound to miR-515-5p. CircPDSS1-mediated actions were dependent on the regulation of miR-515-5p. Besides, miR-515-5p was associated with ITGA11, and circPDSS1 regulated ITGA11 expression by binding to miR-515-5p. Overexpression of miR-515-5p improved DDP sensitivity owing to the downregulation of ITGA11. Further, circPDSS1 mediated DDP sensitivity by regulating miR-515-5p and ITGA11 <i>in vivo</i>. CircPDSS1 conferred DDP resistance through the miR-515-5p/ITGA11 axis in GC cells.
DOI: 10.6084/m9.figshare.7546115.v1
title: Additional file 2: of Dual RNA-seq analysis provides new insights into interactions between Norway spruce and necrotrophic pathogen Heterobasidion annosum s.l.

description: Table S2. List of Norway spruce genes showing higher transcript abundance in symptomatic trees. (XLSX 39 kb)
DOI: 10.6084/m9.figshare.20652814
title: Additional file 10 of Integrated methylome and transcriptome analysis unravel the cold tolerance mechanism in winter rapeseed(Brassica napus L.)

description: Additional file 10. Table S10.1 Result of DMEGs involved in phosphate metabolism under treatment1. Table S10.2 Result of DMEGs involved in phosphate metabolism under treatment2. Table S10.3 Result of DMEGs involved in lipid signal under treatment1. Table S10.4 Result of DMEGs involved in lipid signal under treatment2. Table S10.5 Result of DMEGs involved in carbon fixation under treatment1. Table S10.6 Result of DMEGs involved in carbon fixation under treatment2. Table S10.7 Result of DMEGs involved in sugar metabolism under treatment1. Table S10.8 Result of DMEGs involved in sugar metabolism under treatment2. Table S10.9 Result of DMEGs encoded peroxidase and peroxisome enzymes under treatment1. Table S10.10 Result of DMEGs encoded peroxidase and peroxisome enzymes under treatment2. Table S10.11 Result of DMEGs involved in flavonoid biosynthesis under treatment1. Table S10.12 Result of DMEGs involved in flavonoid biosynthesis under treatment2. Table S10.13 Result of DMEGs involved in plant hormone signal transduction under treatment1. Table S10.14 Result of DMEGs involved in plant hormone signal transduction under treatment2.
DOI: 10.6084/m9.figshare.23274249.v1
title: The complete chloroplast genome of <i>Primula vialii</i> (Primulaceae), an ornamental plant

description: <i>Primula vialii</i> Delavay ex Franch. (1905) is an alpine species with an ornamental value. In this study, we sequenced, assembled, and annotated the chloroplast genome of <i>P. vialii.</i> The results showed that it was a double-stranded, closed circular DNA with 154,897 bp in length, comprising a small single-copy (SSC) region of 17,766 bp, a large single-copy (LSC) region of 85,379 bp and a pair of inverted repeat (IR) regions of 25,876 bp. A total of 113 unique genes were annotated, including 79 protein-coding genes, 30 tRNA genes, and 4 rRNA genes. The phylogenetic analysis revealed that <i>P. vialii</i> is closely related to <i>Primula flaccida.</i> The cp genomic data will be useful for systematics and evolutionary studies of <i>Primula</i>.
DOI: 10.6084/m9.figshare.20652823
title: Additional file 1 of Integrated methylome and transcriptome analysis unravel the cold tolerance mechanism in winter rapeseed(Brassica napus L.)

description: Additional file 1. Table S1.1 The qPCR rimers used in this study. Table S1.2 The effective coverage rates of all chromosomes of all samples. Table S1.3 Number of differentially methylated regions identified in CG, CHG, and CHH contexts between two cultivars of rapeseed. Table S1.4 Distribution of methylation levels in different chromosomes.
DOI: 10.6084/m9.figshare.20652777.v1
title: Additional file 5 of Integrated transcriptomic and transgenic analyses reveal potential mechanisms of poplar resistance to Alternaria alternata infection

description: Additional file 5: Supplementary Table S2. DEGs between samples.
DOI: 10.6084/m9.figshare.20652829.v1
title: Additional file 3 of Integrated methylome and transcriptome analysis unravel the cold tolerance mechanism in winter rapeseed(Brassica napus L.)

description: Additional file 3. Table S3.1 The DMGs between two cultivars under CG context in control. Table S3.2 The DMGs between two cultivars under CHG context in control. Table S3.3 The DMGs between two cultivars under CHH context in control. Table S3.4 The DMGs between two cultivars under CG context in treatment1. Table S3.5 The DMGs between two cultivars under CHG context in treatment1. Table S3.6 The DMGs between two cultivars under CHH context in treatment1. Table S3.7 The DMGs between two cultivars under CG context in treatment2. Table S3.8 The DMGs between two cultivars under CHG context in treatment2. Table S3.9 The DMGs between two cultivars under CHH context in treatment2.
DOI: 10.6084/m9.figshare.23797376
title: Additional file 1 of Immunogenicity and safety of quadrivalent influenza vaccine among young and older adults in Tianjin, China: implication of immunosenescence as a risk factor

description: Additional file 1.
DOI: 10.6084/m9.figshare.23797379
title: Additional file 2 of Immunogenicity and safety of quadrivalent influenza vaccine among young and older adults in Tianjin, China: implication of immunosenescence as a risk factor

description: Additional file 2.
DOI: 10.6084/m9.figshare.20652835
title: Additional file 5 of Integrated methylome and transcriptome analysis unravel the cold tolerance mechanism in winter rapeseed(Brassica napus L.)

description: Additional file 5. Table S5.1 The DEGs between two cultivars in control. Table S5.2 The DEGs between two cultivars in treatment1. Table S5.3 The DEGs between two cultivars in treatment2.
DOI: 10.6084/m9.figshare.12788490
title: Additional file 4 of Genomics-assisted prediction of salt and alkali tolerances and functional marker development in apple rootstocks

description: Additional file 4: Supplementary Table S11. Sample correlation analysis of three biological replicates in RNA-seq. Supplementary Table S12. Differentially expressed genes (DEGs) detected by DESeq2 methods (FDR &lt; 0.05, log2FC &gt; 1 or log2FC &lt; − 1,verticals represent normal genes. Up and down arrows represent up and down) in RNA-seq of salt. Supplementary Table S13. Differentially expressed genes (DEGs) detected by DESeq2 methods (FDR &lt; 0.05, log2FC &gt; 1 or log2FC &lt; − 1, verticals represent normal genes. Up and down arrows represent up and down) in RNA-seq of alkali. Supplementary Table S14. Differentially expressed genes (DEGs) detected by DESeq2 methods (FDR &lt; 0.05, log2FC &gt; 1 or log2FC &lt; − 1,verticals represent normal genes. Up and down arrows represent up and down) in RNA-seq of salt-alkali. Supplementary Table S15. Co-expression network identified by AppleMDO analysis tools in hybrids tolerant or sensitive to salt, alkali, and salt-alkali treatments in hybrids from Malus robusta Rehd. ‘Baleng Crab’ × M. pumila Mill. ‘M9’. Supplementary Table S16. Data for allelic variations of markers using for KASP assay in hybrids from ‘Baleng Crab’ (Malus robusta) × ‘M9’ (M. pumila). Supplementary Table S17. Estimates of marker genotype effects on salt, alkali, and salt-alkali injury indices in hybrids from ‘Baleng Crab’ (Malus robusta) × ‘M9’ (M. pumila). Supplementary Table S18. The marker genotypes, genomics predicted values (GPV), and observed phenotype values (OPV) of alkali injury index in 299 F1 hybrids from ‘Baleng Crab’ (Malus robusta) × ‘M9’ (M. pumila) . Supplementary Table S19. The marker genotypes, genomics predicted values (GPV), and observed phenotype values (OPV) of salt injury index in 285 F1 hybrids from ‘Baleng Crab’ (Malus robusta) × ‘M9’ (M. pumila). Supplementary Table S20. The marker genotypes, genomics predicted values (GPV), and observed phenotype values (OPV) of saline-alkali injury index in 194 F1 hybrids from ‘Baleng Crab’ (Malus robusta) × ‘M9’ (M. pumila)
DOI: 10.6084/m9.figshare.14361632.v1
title: Additional file 1 of Feedback activation of NF-KB signaling leads to adaptive resistance to EZH2 inhibitors in prostate cancer cells

description: Additional file 1. The gene expression profile of LNCaP cells treated with siRNA against EZH2.
DOI: 10.6084/m9.figshare.20652814.v1
title: Additional file 10 of Integrated methylome and transcriptome analysis unravel the cold tolerance mechanism in winter rapeseed(Brassica napus L.)

description: Additional file 10. Table S10.1 Result of DMEGs involved in phosphate metabolism under treatment1. Table S10.2 Result of DMEGs involved in phosphate metabolism under treatment2. Table S10.3 Result of DMEGs involved in lipid signal under treatment1. Table S10.4 Result of DMEGs involved in lipid signal under treatment2. Table S10.5 Result of DMEGs involved in carbon fixation under treatment1. Table S10.6 Result of DMEGs involved in carbon fixation under treatment2. Table S10.7 Result of DMEGs involved in sugar metabolism under treatment1. Table S10.8 Result of DMEGs involved in sugar metabolism under treatment2. Table S10.9 Result of DMEGs encoded peroxidase and peroxisome enzymes under treatment1. Table S10.10 Result of DMEGs encoded peroxidase and peroxisome enzymes under treatment2. Table S10.11 Result of DMEGs involved in flavonoid biosynthesis under treatment1. Table S10.12 Result of DMEGs involved in flavonoid biosynthesis under treatment2. Table S10.13 Result of DMEGs involved in plant hormone signal transduction under treatment1. Table S10.14 Result of DMEGs involved in plant hormone signal transduction under treatment2.
DOI: 10.6084/m9.figshare.20652847.v1
title: Additional file 9 of Integrated methylome and transcriptome analysis unravel the cold tolerance mechanism in winter rapeseed(Brassica napus L.)

description: Additional file 9. Table S9.1 Data of RT-qPCR. Table S9.2 Data of RT-qPCR and RNA-seq.
DOI: 10.6084/m9.figshare.14361632
title: Additional file 1 of Feedback activation of NF-KB signaling leads to adaptive resistance to EZH2 inhibitors in prostate cancer cells

description: Additional file 1. The gene expression profile of LNCaP cells treated with siRNA against EZH2.
DOI: 10.6084/m9.figshare.20652832.v1
title: Additional file 4 of Integrated methylome and transcriptome analysis unravel the cold tolerance mechanism in winter rapeseed(Brassica napus L.)

description: Additional file 4.  Table S4.1 The data of RNA-seq in two cultivars of rapeseed. Table S4.2 Number of differentially expression genes between two cultivars of rapeseed. Table S4.3 Correlation analysis between the three replicates of RNA-seq all libraries.
DOI: 10.5066/p9vztgfn
title: Data release of isotope geochemistry, mineral chemistry, and geochronology for a Proterozoic paragneiss sampled from drill core from North Dakota

description: This U.S. Geological Survey (USGS) data release provides whole rock isotope geochemistry, zircon hafnium isotope geochemistry, feldspar mineral chemistry, and zircon, monazite, and xenotime geochronology for a paragneiss sampled from a drill core from North Dakota. The sample was collected from the 9-11R E-M Larson well in order to constrain the depositional age, provenance, metamorphic history, and geochemical character of basement terranes.