cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.14282191
title: Investigation of the role of rosmarinic acid treatment in regulating inflammation, cell damage, and angiogenesis in rat ovarian torsion and detorsion models

description: Abstract Purpose To investigate the protective effect of rosmarinic acid (RA) in ovarian ischemia/reperfusion injury using biochemical, histopathological, and immunohistochemical methods. Methods Wistar female rats (n = 32) were randomly divided into four groups: control, ischemia, ischemia-reperfusion, and ischemia-reperfusion with RA. Rosmarinic acid was given at a dose of 50 mg/kg by oral gavage three hours after reperfusion. Malondialdehyde (MDA) levels and glutathione peroxidase (GSH-Px) activities were determined in the ovary tissue homogenates for each rat. Results In the ischemia-reperfusion with RA group, the epithelial cells are regularly regulated at the periphery, and the degenerative changes in preantral and antral follicle cells are reduced. Follicle cells and cells in the corpus luteum showed a decrease in vascular endothelial growth factor (VEGF) expression, while VEGF demonstrated a positive reaction in vascular endothelial cells and stromal cells. The TNF-α expression due to the decreased degenerative effect and inflammation was positive in the macrophage cells. The expression of caspase-3 as an apoptosis change was negative in antral follicle cells and granular cells around the antral follicle. Conclusion Different doses of RA may be useful in preventing ischemic damage after vascularization, inflammation, and apoptotic development after ischemia/reperfusion.
DOI: 10.6084/m9.figshare.14282192
title: Comparative analysis between patients undergoing Gastric Bypass and Sleeve Gastroplasty in a private hospital in Sao Luis-MA

description: Abstract Purpose: To compare the satisfaction levels about the surgery and anesthesia management, and to analyze the postoperative outcomes of patients undergoing Gastric Bypass and Sleeve Gastroplasty surgeries in a private hospital in Sao Luís-MA. Methods: The sample consisted of patients undergoing Bypass and Sleeve bariatric surgeries from August 2018 to August 2019, who were in the range of 18 and 70 years old and had not used drugs or presented cardiac arrhythmias, dilated cardiomyopathy, and conduction disorder heart. Data were collected from the evaluation forms and recorded in a form with closed questions. Results: Most patients were female (Bypass – 56% and Sleeve – 67.4%) and aged between 30 and 39 years old (Bypass – 32% and Sleeve – 55.8%). Information (Bypass – 92% and Sleeve – 86.1%) was the highest satisfaction index found. Sleepiness in the immediate postoperative period (Bypass – 92% and Sleeve – 93%) was the main side effect. There were no postoperative complications in patients between the two types of surgery. Conclusions: Patients submitted to Bypass and Sleeve were completely satisfied with the perioperative management. There was no statistically significant difference when comparing adverse effects between the techniques.
DOI: 10.6084/m9.figshare.14282195
title: Morphological and molecular analysis of apoptosis in the corpus cavernosum of rats submitted to a chronic alcoholism model

description: Abstract Purpose To evaluate the effect of chronic alcoholism on morphometry and apoptosis mechanism and correlate with miRNA-21 expression in the corpus cavernosum of rats. Methods Twenty-four rats were divided into two experimental groups: Control (C) and Alcoholic group (A). After two weeks of an adaptive phase, rats from group A received only ethanol solution (20%) during 7 weeks. The morphometric and caspase-3 immunohistochemistry analysis were performed in the corpus cavernosum. The miRNA-21 expression was analyzed in blood and cavernous tissue. Results Chronic ethanol consumption decreased cavernosal smooth muscle area of alcoholic rats. The protein expression of caspase 3 in the corpus cavernosum was higher in A compared to the C group. There was no difference in the expression of miRNA-21 in serum and cavernous tissue between the groups. Conclusion Chronic ethanol consumption reduced smooth muscle area and increased caspase 3 in the corpus cavernosum of rats, without altered serum and cavernosal miR-21 gene expression.
DOI: 10.6084/m9.figshare.14282183.v1
title: A Comparison Between the Atmospheric Component of HWRF System and WRF-HWRF Model Using Different Horizontal Resolutions in Hurricane Irma (2017) Simulation. Part I

description: Abstract A study of several configurations of numerical forecast models was conducted to evaluate their skill to forecast tropical cyclones track and intensity. For this, four configurations of the horizontal domain were selected with 27-9 and 18-6 km of resolution for HWRF (Hurricane Weather Research and Forecasting Model) and four configurations for the WRF (Weather Research and Forecasting Model), using the dynamic core NMM (Non-hydrostatic Mesoscale Model) with the vortex tracker option. Simulations corresponding to Hurricane Irma were done from 1st to 12th September 2017, initialized with GFS (Global Forecast System) forecast outputs. No notable differences were observed between the eight configurations, although the forecast of the intensity of Hurricane Irma was deficient, with an error in the forecast of the maximum wind speed above 50 km/h. The comparison of the outputs of each configuration with buoys and surface meteorological stations data showed that the behavior of the wind speed and atmospheric pressure variables has a similar tendency to the registered values in the stations, with errors lower than 3.8 m/s for wind speed and 3 hPa for atmospheric pressure. HWRF 18-6-m (referred to the model and the horizontal domain resolution) was the configuration that showed the best ability for tropical cyclones forecast, although it require large time to compute.
DOI: 10.6084/m9.figshare.14282192.v1
title: Comparative analysis between patients undergoing Gastric Bypass and Sleeve Gastroplasty in a private hospital in Sao Luis-MA

description: Abstract Purpose: To compare the satisfaction levels about the surgery and anesthesia management, and to analyze the postoperative outcomes of patients undergoing Gastric Bypass and Sleeve Gastroplasty surgeries in a private hospital in Sao Luís-MA. Methods: The sample consisted of patients undergoing Bypass and Sleeve bariatric surgeries from August 2018 to August 2019, who were in the range of 18 and 70 years old and had not used drugs or presented cardiac arrhythmias, dilated cardiomyopathy, and conduction disorder heart. Data were collected from the evaluation forms and recorded in a form with closed questions. Results: Most patients were female (Bypass – 56% and Sleeve – 67.4%) and aged between 30 and 39 years old (Bypass – 32% and Sleeve – 55.8%). Information (Bypass – 92% and Sleeve – 86.1%) was the highest satisfaction index found. Sleepiness in the immediate postoperative period (Bypass – 92% and Sleeve – 93%) was the main side effect. There were no postoperative complications in patients between the two types of surgery. Conclusions: Patients submitted to Bypass and Sleeve were completely satisfied with the perioperative management. There was no statistically significant difference when comparing adverse effects between the techniques.
DOI: 10.6084/m9.figshare.14282195.v1
title: Morphological and molecular analysis of apoptosis in the corpus cavernosum of rats submitted to a chronic alcoholism model

description: Abstract Purpose To evaluate the effect of chronic alcoholism on morphometry and apoptosis mechanism and correlate with miRNA-21 expression in the corpus cavernosum of rats. Methods Twenty-four rats were divided into two experimental groups: Control (C) and Alcoholic group (A). After two weeks of an adaptive phase, rats from group A received only ethanol solution (20%) during 7 weeks. The morphometric and caspase-3 immunohistochemistry analysis were performed in the corpus cavernosum. The miRNA-21 expression was analyzed in blood and cavernous tissue. Results Chronic ethanol consumption decreased cavernosal smooth muscle area of alcoholic rats. The protein expression of caspase 3 in the corpus cavernosum was higher in A compared to the C group. There was no difference in the expression of miRNA-21 in serum and cavernous tissue between the groups. Conclusion Chronic ethanol consumption reduced smooth muscle area and increased caspase 3 in the corpus cavernosum of rats, without altered serum and cavernosal miR-21 gene expression.
DOI: 10.6084/m9.figshare.14268776
title: Effect of low intensity photobiomodulation associated with norbixin-based poly (hydroxybutyrate) membrane on post-tenotomy tendon repair. In vivo study

description: Abstract Purpose: To evaluate the in vivo response of photobiomodulation therapy associated with norbixin-based poly(hydroxybutyrate) membrane (PHB) in tenotomized calcaneal tendon. Methods: Thirty rats were randomly allocated to six groups (n=5 each): LED groups (L1, L2 and L3) and membrane + LED groups (ML1, ML2 and ML3). The right calcaneal tendons of all animals were sectioned transversely and were irradiated with LED daily, one hour after surgery every 24 hours, until the day of euthanasia. At the end of the experiments the tendons were removed for histological analysis. Results: The histological analysis showed a significant reduction in inflammatory cells in the ML1, ML2 and ML3 groups (p=0.0056, p=0.0018 and p&lt;0.0001, respectively) compared to those in the LED group. There was greater proliferation of fibroblasts in the ML1 (p&lt;0.0001) and L3 (p&lt;0.0001) groups. A higher concentration of type I collagen was also observed in the ML1 group (p=0.0043) replacing type III collagen. Conclusion: Photobiomodulation in association with norbixin-based PHB membrane led to control of the inflammatory process. However, it did not favor fibroblast proliferation and did not optimize type I collagen formation in the expected stage of the repair process.
DOI: 10.6084/m9.figshare.14268776.v1
title: Effect of low intensity photobiomodulation associated with norbixin-based poly (hydroxybutyrate) membrane on post-tenotomy tendon repair. In vivo study

description: Abstract Purpose: To evaluate the in vivo response of photobiomodulation therapy associated with norbixin-based poly(hydroxybutyrate) membrane (PHB) in tenotomized calcaneal tendon. Methods: Thirty rats were randomly allocated to six groups (n=5 each): LED groups (L1, L2 and L3) and membrane + LED groups (ML1, ML2 and ML3). The right calcaneal tendons of all animals were sectioned transversely and were irradiated with LED daily, one hour after surgery every 24 hours, until the day of euthanasia. At the end of the experiments the tendons were removed for histological analysis. Results: The histological analysis showed a significant reduction in inflammatory cells in the ML1, ML2 and ML3 groups (p=0.0056, p=0.0018 and p&lt;0.0001, respectively) compared to those in the LED group. There was greater proliferation of fibroblasts in the ML1 (p&lt;0.0001) and L3 (p&lt;0.0001) groups. A higher concentration of type I collagen was also observed in the ML1 group (p=0.0043) replacing type III collagen. Conclusion: Photobiomodulation in association with norbixin-based PHB membrane led to control of the inflammatory process. However, it did not favor fibroblast proliferation and did not optimize type I collagen formation in the expected stage of the repair process.
DOI: 10.6084/m9.figshare.14282197
title: A Review of the Effect of the Chemical Composition of the Atmosphere on the Dry Gas Constant over Multiple Time Scales

description: Abstract The calculation of the dry-air constant depends on the concentrations of the main atmospheric constituents. The variation in N2, O2 and CO2 concentration over the last 23 million years has a small, but calculable, effect on the value of the constant. For modern times, a comparison is made between some estimates in the literature, and a heuristic adjustment of the concentrations of the main components is proposed, in order to account for the CO2 increase during the last decades; a confidence interval for the value of the constant is also estimated. Over longer time scales two periods are analyzed: the Christian era (Period I), and the last 23 Ma (Period II). It is found that the increase in CO2 that started with the Industrial Revolution has an impact on the constant over Period I, but that changes in the constant during Period II are caused by increasing O2 levels.
DOI: 10.6084/m9.figshare.14282197.v1
title: A Review of the Effect of the Chemical Composition of the Atmosphere on the Dry Gas Constant over Multiple Time Scales

description: Abstract The calculation of the dry-air constant depends on the concentrations of the main atmospheric constituents. The variation in N2, O2 and CO2 concentration over the last 23 million years has a small, but calculable, effect on the value of the constant. For modern times, a comparison is made between some estimates in the literature, and a heuristic adjustment of the concentrations of the main components is proposed, in order to account for the CO2 increase during the last decades; a confidence interval for the value of the constant is also estimated. Over longer time scales two periods are analyzed: the Christian era (Period I), and the last 23 Ma (Period II). It is found that the increase in CO2 that started with the Industrial Revolution has an impact on the constant over Period I, but that changes in the constant during Period II are caused by increasing O2 levels.
DOI: 10.6084/m9.figshare.14282200
title: Decision making process in simultaneous laparoscopic resection of colorectal cancer and liver metastases. Review of literature

description: Abstract Purpose: The benefits of laparoscopic approaches to treat colorectal cancer (CRC) and colorectal liver metastases (CRLM) separately are well established. However, there is no consensus about the optimal timing to approach the primary tumor and CRLM, whether simultaneously or staged. The objective of this review with practical reports is to discuss technical aspects required for patient selection to perform simultaneous laparoscopic approaches for CRC and CRLM. Methods: Literature review of oncological factors associated with patient selection for surgical treatment of CRLM and the use of laparoscopy in those cases, and report of technical aspects for simultaneous CRC and CRLM approaches. Results: Simultaneous laparoscopic resection has been successful in many series of selected patients, although it seems to be safer to perform minor and major liver resection with non-extended colorectal resections, and to avoid two high-risk procedures at the same time. Conclusions: Simultaneous CRC and CRLM resections seem to be safe when patients are carefully selected, also considering the risk of recurrence concerning oncologic outcomes. The pre-planning of simultaneous resection is mandatory to plan trocar positioning, procedure sequencing, and patient position.
DOI: 10.6084/m9.figshare.14282200.v1
title: Decision making process in simultaneous laparoscopic resection of colorectal cancer and liver metastases. Review of literature

description: Abstract Purpose: The benefits of laparoscopic approaches to treat colorectal cancer (CRC) and colorectal liver metastases (CRLM) separately are well established. However, there is no consensus about the optimal timing to approach the primary tumor and CRLM, whether simultaneously or staged. The objective of this review with practical reports is to discuss technical aspects required for patient selection to perform simultaneous laparoscopic approaches for CRC and CRLM. Methods: Literature review of oncological factors associated with patient selection for surgical treatment of CRLM and the use of laparoscopy in those cases, and report of technical aspects for simultaneous CRC and CRLM approaches. Results: Simultaneous laparoscopic resection has been successful in many series of selected patients, although it seems to be safer to perform minor and major liver resection with non-extended colorectal resections, and to avoid two high-risk procedures at the same time. Conclusions: Simultaneous CRC and CRLM resections seem to be safe when patients are carefully selected, also considering the risk of recurrence concerning oncologic outcomes. The pre-planning of simultaneous resection is mandatory to plan trocar positioning, procedure sequencing, and patient position.
DOI: 10.6084/m9.figshare.14282203
title: Encouragement to submit manuscripts-suggestions from a Japanese Associate Editor of Acta Cirurgica Brasileira

description: Abstract Medicine can be broadly divided into two fields: clinical medicine that aims to save existing patients and basic medical research that aims to save the lives of future patients. In terms of disseminating basic medical research, medical journals play a vital role for physicians and scientists, as they enable them to share experiences. The author, who has been serving as an Associate Editor of the Brazilian journal Acta Cirurgica Brasileira over a long period of time, wishes to encourage physicians and researchers to submit their papers to medical journals. As we currently face the difficult battle against COVID-19 pandemic, physicians worldwide must team up and fight the virus for the safety of our future generations.
DOI: 10.6084/m9.figshare.14268557
title: Hourly and Daily Reference Evapotranspiration with ASCE-PM Model for Paraná State, Brazil

description: Abstract The objective of this study was to verify the magnitude and trend of hourly reference evapotranspiration (EToh), as well as associate and analyze daily ETo (ETod) series and the sum of hourly ETo (ETo24h) in 24 h, estimated with the Penman-Monteith ASCE model for Paraná State (Cfa and Cfb climate type). Relative humidity (RH), temperature (T), solar radiation (Rs) and wind speed (u2) data were obtained from 25 meteorological stations from the National Meteorological Institute (INMET), between December 1, 2016 to November 8, 2018. The analyzes were performed by linear regression and associations considering the root mean square error, correlation coefficient and index of agreement. The EToh trend has a Gaussian distribution, with the highest values between 12:00 p.m. and 2:00 p.m., with the maximum average being 0.44 mm h−1 (Cfa climate type) and 0.35 mm h−1 (Cfb climate type). The average difference between the ETo24h and ETod values was small (5.1% for Cfa and 7.4% for Cfb), resulting in close linear associations. The results obtained indicate that EToh has good potential to be used in planning and management in the field of soil and water engineering, in Paraná State.
DOI: 10.6084/m9.figshare.14268557.v1
title: Hourly and Daily Reference Evapotranspiration with ASCE-PM Model for Paraná State, Brazil

description: Abstract The objective of this study was to verify the magnitude and trend of hourly reference evapotranspiration (EToh), as well as associate and analyze daily ETo (ETod) series and the sum of hourly ETo (ETo24h) in 24 h, estimated with the Penman-Monteith ASCE model for Paraná State (Cfa and Cfb climate type). Relative humidity (RH), temperature (T), solar radiation (Rs) and wind speed (u2) data were obtained from 25 meteorological stations from the National Meteorological Institute (INMET), between December 1, 2016 to November 8, 2018. The analyzes were performed by linear regression and associations considering the root mean square error, correlation coefficient and index of agreement. The EToh trend has a Gaussian distribution, with the highest values between 12:00 p.m. and 2:00 p.m., with the maximum average being 0.44 mm h−1 (Cfa climate type) and 0.35 mm h−1 (Cfb climate type). The average difference between the ETo24h and ETod values was small (5.1% for Cfa and 7.4% for Cfb), resulting in close linear associations. The results obtained indicate that EToh has good potential to be used in planning and management in the field of soil and water engineering, in Paraná State.
DOI: 10.6084/m9.figshare.14282201.v1
title: Hepathic, biochemical, hematological, and histological effects of the ultracavitation in rabbits livers

description: Abstract Purpose To collect data capable of pointing out the effects of the ultracavitation treatment on the liver of rabbits after adipose tissue application, by means of histological analyses of the liver and hematological and biochemical exams. Methods This is an experimental study with 12 albino rabbits as sample, which were divided into 3 groups and submitted to a hypercaloric diet for one month. Subsequently, subjects underwent UCV treatment: 3 minutes, 30 W, continuous mode at 100%, every 2 ERAS = 441.02 J/cm2, intensity of 10w/cm2. They were then euthanized and underwent biopsy after 24 hours. Results After 48 hours from the ultracavitation treatment, the animals’ livers presented greater amount of fat infiltration if compared to the amount presented 96 hours after the treatment. However, laboratory tests showed no alterations. Values were maintained within normal parameters of cholesterol, triglycerides, liver enzymes, hemoglobin and hematocrit levels. Conclusions This study has identified that infiltrates may appear on livers after the treatment, despite high hematological and biochemical tests results. The fat infiltrates reduction 96 h after treatment suggests lower risks to animal health, if the period between applications is respected.
DOI: 10.6084/m9.figshare.14282203.v1
title: Encouragement to submit manuscripts-suggestions from a Japanese Associate Editor of Acta Cirurgica Brasileira

description: Abstract Medicine can be broadly divided into two fields: clinical medicine that aims to save existing patients and basic medical research that aims to save the lives of future patients. In terms of disseminating basic medical research, medical journals play a vital role for physicians and scientists, as they enable them to share experiences. The author, who has been serving as an Associate Editor of the Brazilian journal Acta Cirurgica Brasileira over a long period of time, wishes to encourage physicians and researchers to submit their papers to medical journals. As we currently face the difficult battle against COVID-19 pandemic, physicians worldwide must team up and fight the virus for the safety of our future generations.
DOI: 10.6084/m9.figshare.14282201
title: Hepathic, biochemical, hematological, and histological effects of the ultracavitation in rabbits livers

description: Abstract Purpose To collect data capable of pointing out the effects of the ultracavitation treatment on the liver of rabbits after adipose tissue application, by means of histological analyses of the liver and hematological and biochemical exams. Methods This is an experimental study with 12 albino rabbits as sample, which were divided into 3 groups and submitted to a hypercaloric diet for one month. Subsequently, subjects underwent UCV treatment: 3 minutes, 30 W, continuous mode at 100%, every 2 ERAS = 441.02 J/cm2, intensity of 10w/cm2. They were then euthanized and underwent biopsy after 24 hours. Results After 48 hours from the ultracavitation treatment, the animals’ livers presented greater amount of fat infiltration if compared to the amount presented 96 hours after the treatment. However, laboratory tests showed no alterations. Values were maintained within normal parameters of cholesterol, triglycerides, liver enzymes, hemoglobin and hematocrit levels. Conclusions This study has identified that infiltrates may appear on livers after the treatment, despite high hematological and biochemical tests results. The fat infiltrates reduction 96 h after treatment suggests lower risks to animal health, if the period between applications is respected.