cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.13107585.v1
title: Additional file 4 of Analysis of the microRNA expression profiles of chicken dendritic cells in response to H9N2 avian influenza virus infection

description: Additional file 4. MiRNA profile of H9N2-infected and mock-infected DCs. In total, 994 known and 9208 novel miRNAs were identified in all samples.
DOI: 10.6084/m9.figshare.13107600.v1
title: Additional file 9 of Analysis of the microRNA expression profiles of chicken dendritic cells in response to H9N2 avian influenza virus infection

description: Additional file 9. Primers used to detect miRNA and target mRNA expression levels with quantitative RT-PCR.
DOI: 10.6084/m9.figshare.13107582
title: Additional file 3 of Analysis of the microRNA expression profiles of chicken dendritic cells in response to H9N2 avian influenza virus infection

description: Additional file 3. Summary of small RNAs sequencing data. M: mock-infected DCs; V: H9N2 AIV-infected DCs.
DOI: 10.6084/m9.figshare.13107582.v1
title: Additional file 3 of Analysis of the microRNA expression profiles of chicken dendritic cells in response to H9N2 avian influenza virus infection

description: Additional file 3. Summary of small RNAs sequencing data. M: mock-infected DCs; V: H9N2 AIV-infected DCs.
DOI: 10.6084/m9.figshare.14680514
title: A pilot study of thiamin and folic acid in hemodialysis patients with cognitive impairment

description: This study aimed to explore the effectiveness of thiamin and folic acid supplementation on the improvement of the cognitive function in patients with maintenance hemodialysis. In the present study, we randomly assigned patients undergoing hemodialysis who had the Montreal Cognitive Assessment (MoCA) score lower than 26 to treatment group (<i>n</i> = 25, thiamin 90 mg/day combined with folic acid 30 mg/day) or control group (<i>n</i> = 25, nonintervention). All subjects were followed up for 96 weeks. The primary outcome was the improvement of the MoCA score. The secondary outcomes included homocysteine level, survival and safety. Patients in treatment group had an increase of the MoCA score from 21.95 ± 3.81 at baseline to 25.68 ± 1.96 at week 96 (<i>p</i> &lt; 0.001, primary outcome), as compared with the MoCA score from 20.69 ± 3.40 to 19.62 ± 3.58 in control group. Thiamin combined with folic acid treatment also resulted in lower level of serum homocysteine in treatment group compare with control group at week 96 (<i>p</i> &lt; 0.05, secondary outcome). 3 patients and 9 patients died during follow-up period in treatment and control group respectively (<i>p</i> = 0.048). The proportion of adverse events in treatment group was significantly lower than that in control group. Hemodialysis patients with cognitive impairment treated with thiamin and folic acid had a significant improvement in MoCA score.
DOI: 10.6084/m9.figshare.14680514.v1
title: A pilot study of thiamin and folic acid in hemodialysis patients with cognitive impairment

description: This study aimed to explore the effectiveness of thiamin and folic acid supplementation on the improvement of the cognitive function in patients with maintenance hemodialysis. In the present study, we randomly assigned patients undergoing hemodialysis who had the Montreal Cognitive Assessment (MoCA) score lower than 26 to treatment group (<i>n</i> = 25, thiamin 90 mg/day combined with folic acid 30 mg/day) or control group (<i>n</i> = 25, nonintervention). All subjects were followed up for 96 weeks. The primary outcome was the improvement of the MoCA score. The secondary outcomes included homocysteine level, survival and safety. Patients in treatment group had an increase of the MoCA score from 21.95 ± 3.81 at baseline to 25.68 ± 1.96 at week 96 (<i>p</i> &lt; 0.001, primary outcome), as compared with the MoCA score from 20.69 ± 3.40 to 19.62 ± 3.58 in control group. Thiamin combined with folic acid treatment also resulted in lower level of serum homocysteine in treatment group compare with control group at week 96 (<i>p</i> &lt; 0.05, secondary outcome). 3 patients and 9 patients died during follow-up period in treatment and control group respectively (<i>p</i> = 0.048). The proportion of adverse events in treatment group was significantly lower than that in control group. Hemodialysis patients with cognitive impairment treated with thiamin and folic acid had a significant improvement in MoCA score.
DOI: 10.6084/m9.figshare.15110002.v1
title: Additional file 9 of Comprehensive analysis of lncRNAs involved in skeletal muscle development in ZBED6-knockout Bama pigs

description: Additional file 9. Supplementary Table S9. KEGG enrichment of 30 commonly expressed lncRNAs.
DOI: 10.6084/m9.figshare.15109996
title: Additional file 7 of Comprehensive analysis of lncRNAs involved in skeletal muscle development in ZBED6-knockout Bama pigs

description: Additional file 7. Supplementary Table S7. List of lncRNA modules.
DOI: 10.6084/m9.figshare.15109996.v1
title: Additional file 7 of Comprehensive analysis of lncRNAs involved in skeletal muscle development in ZBED6-knockout Bama pigs

description: Additional file 7. Supplementary Table S7. List of lncRNA modules.
DOI: 10.6084/m9.figshare.15110002
title: Additional file 9 of Comprehensive analysis of lncRNAs involved in skeletal muscle development in ZBED6-knockout Bama pigs

description: Additional file 9. Supplementary Table S9. KEGG enrichment of 30 commonly expressed lncRNAs.
DOI: 10.6084/m9.figshare.15109999
title: Additional file 8 of Comprehensive analysis of lncRNAs involved in skeletal muscle development in ZBED6-knockout Bama pigs

description: Additional file 8. Supplementary Table S8. Cis- and trans-target genes predicted to be regulated by 30 commonly expressed lncRNAs in longissimus dorsi tissue-specific expression (tissue-specific), skeletal muscle module (magenta module) and DE-lncRNAs of longissimus dorsi (LD_DE-lncRNAs).
DOI: 10.6084/m9.figshare.15109999.v1
title: Additional file 8 of Comprehensive analysis of lncRNAs involved in skeletal muscle development in ZBED6-knockout Bama pigs

description: Additional file 8. Supplementary Table S8. Cis- and trans-target genes predicted to be regulated by 30 commonly expressed lncRNAs in longissimus dorsi tissue-specific expression (tissue-specific), skeletal muscle module (magenta module) and DE-lncRNAs of longissimus dorsi (LD_DE-lncRNAs).
DOI: 10.6084/m9.figshare.14680564
title: Pan-coronavirus fusion inhibitors possess potent inhibitory activity against HIV-1, HIV-2, and simian immunodeficiency virus

description: EK1 peptide is a membrane fusion inhibitor with broad-spectrum activity against human coronaviruses (CoVs). In the outbreak of COVID-19, we generated a lipopeptide EK1V1 by modifying EK1 with cholesterol, which exhibited significantly improved antiviral activity. In this study, we surprisingly found that EK1V1 also displayed potent cross-inhibitory activities against divergent HIV-1, HIV-2, and simian immunodeficiency virus (SIV) isolates. Consistently, the recently reported EK1 derivative EK1C4 and SARS-CoV-2 derived fusion inhibitor lipopeptides (IPB02 ∼ IPB09) also inhibited HIV-1 Env-mediated cell–cell fusion and infection efficiently. In the inhibition of a panel of HIV-1 mutants resistant to HIV-1 fusion inhibitors, EK1V1 and IPB02-based inhibitors exhibited significantly decreased or increased activities, suggesting the heptad repeat-1 region (HR1) of HIV-1 gp41 being their target. Furthermore, the sequence alignment and molecular docking analyses verified the target site and revealed the mechanism underlying the resistance. Combined, we conclude that this serendipitous discovery provides a proof-of-concept for a common mechanism of viral fusion and critical information for the development of broad-spectrum antivirals.
DOI: 10.6084/m9.figshare.14680564.v1
title: Pan-coronavirus fusion inhibitors possess potent inhibitory activity against HIV-1, HIV-2, and simian immunodeficiency virus

description: EK1 peptide is a membrane fusion inhibitor with broad-spectrum activity against human coronaviruses (CoVs). In the outbreak of COVID-19, we generated a lipopeptide EK1V1 by modifying EK1 with cholesterol, which exhibited significantly improved antiviral activity. In this study, we surprisingly found that EK1V1 also displayed potent cross-inhibitory activities against divergent HIV-1, HIV-2, and simian immunodeficiency virus (SIV) isolates. Consistently, the recently reported EK1 derivative EK1C4 and SARS-CoV-2 derived fusion inhibitor lipopeptides (IPB02 ∼ IPB09) also inhibited HIV-1 Env-mediated cell–cell fusion and infection efficiently. In the inhibition of a panel of HIV-1 mutants resistant to HIV-1 fusion inhibitors, EK1V1 and IPB02-based inhibitors exhibited significantly decreased or increased activities, suggesting the heptad repeat-1 region (HR1) of HIV-1 gp41 being their target. Furthermore, the sequence alignment and molecular docking analyses verified the target site and revealed the mechanism underlying the resistance. Combined, we conclude that this serendipitous discovery provides a proof-of-concept for a common mechanism of viral fusion and critical information for the development of broad-spectrum antivirals.
DOI: 10.6084/m9.figshare.19923459
title: Starch synthesis and gelatinization properties of potato tubers

description: ABSTRACT: Biosynthesis is the only source of potato starch which is an important raw material for food processing, modified starch and biomass energy. However, it is not clear about the evolution of starch synthesis with tuber development in potato. The present study evaluated the differences of starch synthesis and gelatinization properties of potato tubers with different starch content. Relative to cultivars of medium and low starch content, cultivars of high starch content showed significantly higher SBEII gene expression, AGPase and SSS enzyme activity, and total starch content after middle stage of starch accumulation, and had smaller average starch granule size during whole process of tuber development, and had higher pasting temperature before late stages of tuber growth, and had lower pasting temperature after middle stage of starch accumulation. Path analysis showed that, after middle stage of starch accumulation, effects on starch gelatinization of cultivars with high, medium and low starch content represented starch synthesis enzyme activity &gt; starch accumulation &gt; starch granule distribution &gt; starch synthesis enzyme gene expression, starch synthesis enzyme gene expression &gt; starch synthesis enzyme activity &gt; starch accumulation &gt; starch granule distribution, starch synthesis enzyme gene expression &gt; starch granule distribution &gt; starch synthesis enzyme activity &gt; starch accumulation, respectively. In the study, phases existed in the starch biosynthesis of potato tuber, and the starch quality and its formation process were different among varieties with different starch content. The findings might contribute to starch application and potato industries.
DOI: 10.6084/m9.figshare.19923459.v1
title: Starch synthesis and gelatinization properties of potato tubers

description: ABSTRACT: Biosynthesis is the only source of potato starch which is an important raw material for food processing, modified starch and biomass energy. However, it is not clear about the evolution of starch synthesis with tuber development in potato. The present study evaluated the differences of starch synthesis and gelatinization properties of potato tubers with different starch content. Relative to cultivars of medium and low starch content, cultivars of high starch content showed significantly higher SBEII gene expression, AGPase and SSS enzyme activity, and total starch content after middle stage of starch accumulation, and had smaller average starch granule size during whole process of tuber development, and had higher pasting temperature before late stages of tuber growth, and had lower pasting temperature after middle stage of starch accumulation. Path analysis showed that, after middle stage of starch accumulation, effects on starch gelatinization of cultivars with high, medium and low starch content represented starch synthesis enzyme activity &gt; starch accumulation &gt; starch granule distribution &gt; starch synthesis enzyme gene expression, starch synthesis enzyme gene expression &gt; starch synthesis enzyme activity &gt; starch accumulation &gt; starch granule distribution, starch synthesis enzyme gene expression &gt; starch granule distribution &gt; starch synthesis enzyme activity &gt; starch accumulation, respectively. In the study, phases existed in the starch biosynthesis of potato tuber, and the starch quality and its formation process were different among varieties with different starch content. The findings might contribute to starch application and potato industries.
DOI: 10.6084/m9.figshare.13107700
title: Additional file 2 of Enhancing the insecticidal activity of new Bacillus thuringiensis X023 by copper ions

description: Additional file 2: Fig. S3. ICPs identified by the proteomics.
DOI: 10.6084/m9.figshare.13107703
title: Additional file 3 of Enhancing the insecticidal activity of new Bacillus thuringiensis X023 by copper ions

description: Additional file 3: Fig. S3. Differential proteome which CK compared to CU.
DOI: 10.6084/m9.figshare.13107706
title: Additional file 4 of Enhancing the insecticidal activity of new Bacillus thuringiensis X023 by copper ions

description: Additional file 4: Fig. S3. the primers for qRT-PCR.
DOI: 10.6084/m9.figshare.13107706.v1
title: Additional file 4 of Enhancing the insecticidal activity of new Bacillus thuringiensis X023 by copper ions

description: Additional file 4: Fig. S3. the primers for qRT-PCR.
DOI: 10.6084/m9.figshare.13107700.v1
title: Additional file 2 of Enhancing the insecticidal activity of new Bacillus thuringiensis X023 by copper ions

description: Additional file 2: Fig. S3. ICPs identified by the proteomics.
DOI: 10.6084/m9.figshare.13107703.v1
title: Additional file 3 of Enhancing the insecticidal activity of new Bacillus thuringiensis X023 by copper ions

description: Additional file 3: Fig. S3. Differential proteome which CK compared to CU.
DOI: 10.6084/m9.figshare.13107636
title: Additional file 2 of Epigenome-wide association study of Alzheimer’s disease replicates 22 differentially methylated positions and 30 differentially methylated regions

description: Additional file 2. Supplemental Tables S1–S7.
DOI: 10.6084/m9.figshare.13107636.v1
title: Additional file 2 of Epigenome-wide association study of Alzheimer’s disease replicates 22 differentially methylated positions and 30 differentially methylated regions

description: Additional file 2. Supplemental Tables S1–S7.
DOI: 10.6084/m9.figshare.23593617
title: Livestock grazing strengthens the effect of vole activity on soil microbial community

description: A 9-year manipulative experiment to investigate the effects of Brandt's vole (<em>Lasiopodomys brandtii</em>) on soil microbial communities under varying levels of livestock grazing intensity in temperate steppe ecosystems.
DOI: 10.6084/m9.figshare.13107708.v1
title: Additional file 1 of Network analysis of autistic disease comorbidities in Chinese children based on ICD-10 codes

description: Additional file 1. Table 1. Disease generalization in ICD-10 codes. Table 2. Comparison among OMOP ID, Concept Code and the generlization ICD-10 codes. Table 3. The rules verified by literatures. Table 4. The rules discoveried by FP-growth algorithm.
DOI: 10.6084/m9.figshare.24117920
title: High-Resolution Lead–Lag Relations Between Barents Sea Temperatures, the AMOC and the AMO During 1971–2018

description: The direction of heat transport from the atmosphere to the Barents Sea, and between the Barents Sea and the North Atlantic is important for understanding the interplay between Greenland ice melting and anthropogenic forcing. Here, we show how heat has been transported between water bodies by using a high-resolution lead-lag technique that identifies leading relations between cyclic temperature series. The results demonstrate that near-surface ocean temperature (0–30 m) in the Barents Sea led the temperature changes in its intermediate waters (100–200 m) during the period 1971 to 2018 inferring that heat transport is from the atmosphere to the intermediate waters. The Barents Sea’s temperatures lagged the Atlantic meridional overturning circulation (AMOC) and the Atlantic multidecadal oscillation (AMO) from 1971 to 2000. The AMOC was leading the Barents Sea near-bottom temperatures in the West (the Bear Island Through) during 1980–2018 but was both leading and lagging in the Barents Sea Northeast.
DOI: 10.6084/m9.figshare.13107708
title: Additional file 1 of Network analysis of autistic disease comorbidities in Chinese children based on ICD-10 codes

description: Additional file 1. Table 1. Disease generalization in ICD-10 codes. Table 2. Comparison among OMOP ID, Concept Code and the generlization ICD-10 codes. Table 3. The rules verified by literatures. Table 4. The rules discoveried by FP-growth algorithm.
DOI: 10.15156/bio/sh1988547.08fu
title: SH1988547.08FU

description: UNITE provides a unified way for delimiting, identifying, communicating, and working with DNA-based Species Hypotheses (SH). All fungal ITS sequences in the international nucleotide sequence databases are clustered to approximately the species level by applying a set of dynamic distance values (<0.5 - 3.0%). All species hypotheses are given a unique, stable name in the form of a DOI, and their taxonomic and ecological annotations are verified through distributed, web-based third-party annotation efforts. SHs are connected to a taxon name and its classification as far as possible (phylum, class, order, etc.) by taking into account identifications for all sequences in the SH. An automatically or manually designated sequence is chosen to represent each such SH. These sequences are released (https://unite.ut.ee/repository.php) for use by the scientific community in, for example, local sequence similarity searches and next-generation sequencing analysis pipelines. The system and the data are updated automatically as the number of public fungal ITS sequences grows.
DOI: 10.15156/bio/sh1988548.08fu
title: SH1988548.08FU

description: UNITE provides a unified way for delimiting, identifying, communicating, and working with DNA-based Species Hypotheses (SH). All fungal ITS sequences in the international nucleotide sequence databases are clustered to approximately the species level by applying a set of dynamic distance values (<0.5 - 3.0%). All species hypotheses are given a unique, stable name in the form of a DOI, and their taxonomic and ecological annotations are verified through distributed, web-based third-party annotation efforts. SHs are connected to a taxon name and its classification as far as possible (phylum, class, order, etc.) by taking into account identifications for all sequences in the SH. An automatically or manually designated sequence is chosen to represent each such SH. These sequences are released (https://unite.ut.ee/repository.php) for use by the scientific community in, for example, local sequence similarity searches and next-generation sequencing analysis pipelines. The system and the data are updated automatically as the number of public fungal ITS sequences grows.
DOI: 10.15156/bio/sh2679044.08fu
title: SH2679044.08FU

description: UNITE provides a unified way for delimiting, identifying, communicating, and working with DNA-based Species Hypotheses (SH). All fungal ITS sequences in the international nucleotide sequence databases are clustered to approximately the species level by applying a set of dynamic distance values (<0.5 - 3.0%). All species hypotheses are given a unique, stable name in the form of a DOI, and their taxonomic and ecological annotations are verified through distributed, web-based third-party annotation efforts. SHs are connected to a taxon name and its classification as far as possible (phylum, class, order, etc.) by taking into account identifications for all sequences in the SH. An automatically or manually designated sequence is chosen to represent each such SH. These sequences are released (https://unite.ut.ee/repository.php) for use by the scientific community in, for example, local sequence similarity searches and next-generation sequencing analysis pipelines. The system and the data are updated automatically as the number of public fungal ITS sequences grows.
DOI: 10.15156/bio/sh2679045.08fu
title: SH2679045.08FU

description: UNITE provides a unified way for delimiting, identifying, communicating, and working with DNA-based Species Hypotheses (SH). All fungal ITS sequences in the international nucleotide sequence databases are clustered to approximately the species level by applying a set of dynamic distance values (<0.5 - 3.0%). All species hypotheses are given a unique, stable name in the form of a DOI, and their taxonomic and ecological annotations are verified through distributed, web-based third-party annotation efforts. SHs are connected to a taxon name and its classification as far as possible (phylum, class, order, etc.) by taking into account identifications for all sequences in the SH. An automatically or manually designated sequence is chosen to represent each such SH. These sequences are released (https://unite.ut.ee/repository.php) for use by the scientific community in, for example, local sequence similarity searches and next-generation sequencing analysis pipelines. The system and the data are updated automatically as the number of public fungal ITS sequences grows.
DOI: 10.15156/bio/sh2679046.08fu
title: SH2679046.08FU

description: UNITE provides a unified way for delimiting, identifying, communicating, and working with DNA-based Species Hypotheses (SH). All fungal ITS sequences in the international nucleotide sequence databases are clustered to approximately the species level by applying a set of dynamic distance values (<0.5 - 3.0%). All species hypotheses are given a unique, stable name in the form of a DOI, and their taxonomic and ecological annotations are verified through distributed, web-based third-party annotation efforts. SHs are connected to a taxon name and its classification as far as possible (phylum, class, order, etc.) by taking into account identifications for all sequences in the SH. An automatically or manually designated sequence is chosen to represent each such SH. These sequences are released (https://unite.ut.ee/repository.php) for use by the scientific community in, for example, local sequence similarity searches and next-generation sequencing analysis pipelines. The system and the data are updated automatically as the number of public fungal ITS sequences grows.
DOI: 10.15156/bio/sh1988549.08fu
title: SH1988549.08FU

description: UNITE provides a unified way for delimiting, identifying, communicating, and working with DNA-based Species Hypotheses (SH). All fungal ITS sequences in the international nucleotide sequence databases are clustered to approximately the species level by applying a set of dynamic distance values (<0.5 - 3.0%). All species hypotheses are given a unique, stable name in the form of a DOI, and their taxonomic and ecological annotations are verified through distributed, web-based third-party annotation efforts. SHs are connected to a taxon name and its classification as far as possible (phylum, class, order, etc.) by taking into account identifications for all sequences in the SH. An automatically or manually designated sequence is chosen to represent each such SH. These sequences are released (https://unite.ut.ee/repository.php) for use by the scientific community in, for example, local sequence similarity searches and next-generation sequencing analysis pipelines. The system and the data are updated automatically as the number of public fungal ITS sequences grows.