cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.34808/g1mk-qc08
title: Construction, production and evaluation of the diagnostic utility of a recombinant Toxoplasma gondii chimeric antigen SAG1-SAG2-MIC1L

description: The intracellular parasite Toxoplasma gondii has the ability to infect a wide range of warm-blooded animals, including humans. Currently, diagnosis of toxoplasmosis is based mainly on the use of the native antigens in enzyme immunoassay which allow for detection of IgG, IgM and IgA antibody classes. However, in some cases the performed studies give the ambiguous results. Moreover, the commercially available diagnostic tests due to its price are not generally applicable in the serodiagnosis of toxoplasmosis in animals, which requires the analysis of a large number of samples. For this reason, many research groups are currently working on new diagnostic tools, which are mainly recombinant antigens. Compared to the native antigens their production is much easier, cheaper, faster and safer. An additional advantage of the recombinant antigens is easier way to standardize assays.This study presents the construction of an efficient Escherichia coli expression system for the production of recombinant chimeric protein composed of the immunodominant regions of three Toxoplasma gondii antigens SAG1, SAG2 and MIC1. The produced and purified protein is composed of amino acid residues from: 49-311 of the SAG1 antigen, 30-170 of the SAG2 antigen, 25-456 of the MIC1 antigen. In the next part of the work the diagnostic usefulness of obtaining proteins for detection of anti-T. gondii antibodies were evaluated in the IgG ELISA assay and agglutination test using animal sera (e.g. horses, ovine, and pigs) and human serum samples.
DOI: 10.34808/hr59-3135
title: Construction, production and evaluation of the diagnostic utility of a recombinant Toxoplasma gondii chimeric antigen SAG1-SAG2-MIC1S

description: The intracellular parasite Toxoplasma gondii has the ability to infect a wide range of warm-blooded animals, including humans. Currently, diagnosis of toxoplasmosis is based mainly on the use of the native antigens in enzyme immunoassay which allow for detection of IgG, IgM and IgA antibody classes. However, in some cases the performed studies give the ambiguous results. Moreover, the commercially available diagnostic tests due to its price are not generally applicable in the serodiagnosis of toxoplasmosis in animals, which requires the analysis of a large number of samples. For this reason, many research groups are currently working on new diagnostic tools, which are mainly recombinant antigens. Compared to the native antigens their production is much easier, cheaper, faster and safer. An additional advantage of the recombinant antigens is easier way to standardize assays. This study presents the construction of an efficient Escherichia coli expression system for the production of recombinant chimeric protein composed of the immunodominant regions of three Toxoplasma gondii antigens SAG1, SAG2 and MIC1. The produced and purified protein is composed of amino acid residues from: 49-311 of the SAG1 antigen, 30-170 of the SAG2 antigen, 25-182 of the MIC1 antigen (the immunodominant fragment well recognized by antibodies in the early stage of parasite invasion). In the next part of the work the diagnostic usefulness of obtaining proteins for detection of anti-T. gondii antibodies were evaluated in the IgG ELISA assay and agglutination test using animal sera (e.g. horses, ovine, and pigs) and human serum samples.
DOI: 10.34808/x3tx-9716
title: Construction, production and evaluation of the diagnostic utility of a recombinant Toxoplasma gondii chimeric antigen SAG1-SAG2-GRA6

description: The intracellular parasite Toxoplasma gondii has the ability to infect a wide range of warm-blooded animals, including humans. Currently, diagnosis of toxoplasmosis is based mainly on the use of the native antigens in enzyme immunoassay which allow for detection of IgG, IgM and IgA antibody classes. However, in some cases the performed studies give the ambiguous results. Moreover, the commercially available diagnostic tests due to its price are not generally applicable in the serodiagnosis of toxoplasmosis in animals, which requires the analysis of a large number of samples. For this reason, many research groups are currently working on new diagnostic tools, which are mainly recombinant antigens. Compared to the native antigens their production is much easier, cheaper, faster and safer. An additional advantage of the recombinant antigens is easier way to standardize assays.This study presents the construction of an efficient Escherichia coli expression system for the production of recombinant chimeric protein composed of the immunodominant regions of three Toxoplasma gondii antigens SAG1, SAG2 and GRA6. The produced and purified protein is composed of amino acid residues from: 49-311 of the SAG1 antigen, 30-170 of the SAG2 antigen, 30-230 of the GRA6 antigen. In the next part of the work the diagnostic usefulness of obtaining proteins for detection of anti-T. gondii antibodies were evaluated in the IgG ELISA assay and agglutination test using animal sera (e.g. horses, ovine, and pigs) and human serum samples.
DOI: 10.14278/rodare.898
title: Numerical and experimental data set obtained from paraffin phantom measurements based on the capacitance wire-mesh sensor.

description: This data set contains experimental and numerical data from a 12x12 wire-mesh sensor. A 12x12 WMS was used to measure paraffin phantoms created to mimic three flow patterns: slug, annular and bubble flow. The sensor was assembled with flanges and filled with tap water. Two models based on finite element model were used to generate the synthetic data. The first one is a basic FEM model, which was designed based on other models reported in the literature (i.e. the output signal is obtained by integrating the current density over the surface of a receiver wire). In the second model (FEM+EC), the electric potential is solved as the basic one, however, external circuits (macromodels) were coupled to the 3D geometry of the sensor to emulate the excitation and amplification systems of a real WMS.A mapping containing the coordinates and electrical properties of the paraffin phantoms was created through image processing and imported into the software COMSOL v.5.6. Thus, both basic FEM and FEM+EC models were used to generate synthetic data that can be direct compared to the experimental data.
DOI: 10.14278/rodare.897
title: Numerical and experimental data set obtained from paraffin phantom measurements based on the capacitance wire-mesh sensor.

description: This data set contains experimental and numerical data from a 12x12 wire-mesh sensor. A 12x12 WMS was used to measure paraffin phantoms created to mimic three flow patterns: slug, annular and bubble flow. The sensor was assembled with flanges and filled with tap water. Two models based on finite element model were used to generate the synthetic data. The first one is a basic FEM model, which was designed based on other models reported in the literature (i.e. the output signal is obtained by integrating the current density over the surface of a receiver wire). In the second model (FEM+EC), the electric potential is solved as the basic one, however, external circuits (macromodels) were coupled to the 3D geometry of the sensor to emulate the excitation and amplification systems of a real WMS.A mapping containing the coordinates and electrical properties of the paraffin phantoms was created through image processing and imported into the software COMSOL v.5.6. Thus, both basic FEM and FEM+EC models were used to generate synthetic data that can be direct compared to the experimental data.
DOI: 10.6084/m9.figshare.14346038
title: Forbush decreases (FDs) list with FD magnitudes &gt; 3 derived from Izmiran FD catalogue

description: Forbush decreases (FDs) list used in study "The possible impact of cosmic rays on extratropical cyclone frequency and strength over North Atlantic", Calogovic et al., 2021
DOI: 10.6084/m9.figshare.14346038.v1
title: Forbush decreases (FDs) list with FD magnitudes &gt; 3 derived from Izmiran FD catalogue

description: Forbush decreases (FDs) list used in study "The possible impact of cosmic rays on extratropical cyclone frequency and strength over North Atlantic", Calogovic et al., 2021
DOI: 10.5281/zenodo.4650406
title: Molecular dynamics shows complex interplay and long-range effects of post-translational modifications in yeast protein interactions

description: This data set contains i. input topologies and coordinates for 179 non-modified and post-translationally modified (174 in normal and 87 in stress conditions) yeast protein complexes, ii. scripts and parameters for performing molecular dynamics simulations and binding energy calculation with per-residue decomposition, iii. trajectory snapshots of solvent stripped protein complexes, which can be visualized using the corresponding topology files, iv. RMSD calculations (backbone and entire protein) from the production phase of the MD, and v. pdb of the representative structure of the largest cluster from 100 snapshots of the last 10 ns in each simulation. Additionally, PTMs_map.zip contains a Python script (together with an example) for automated addition of PTMs to protein structures using PyTMs in PyMOL.
DOI: 10.5281/zenodo.4099098
title: Molecular dynamics shows complex interplay and long-range effects of post-translational modifications in yeast protein interactions

description: This data set contains i. input topologies and coordinates for 179 non-modified and post-translationally modified (174 in normal and 87 in stress conditions) yeast protein complexes, ii. scripts and parameters for performing molecular dynamics simulations and binding energy calculation with per-residue decomposition, iii. trajectory snapshots of solvent stripped protein complexes, which can be visualized using the corresponding topology files, iv. RMSD calculations (backbone and entire protein) from the production phase of the MD, and v. pdb of the representative structure of the largest cluster from 100 snapshots of the last 10 ns in each simulation. Additionally, PTMs_map.zip contains a Python script (together with an example) for automated addition of PTMs to protein structures using PyTMs in PyMOL.
DOI: 10.25646/8257
title: Tagesdaten-CSV aus dem DIVI-Intensivregister

description: Die Tagesdaten-CSV entspricht einem Auszug der Daten des DIVI-Intensivregisters. Die Datei enthält eine Aggregation der aktuellsten Meldungen pro Landkreis. Es werden die aktuell gemeldeten Anzahlen der COVID-19 Intensivfälle sowie die gemeldeten intensivmedizinischen Behandlungskapazitäten angezeigt. Die Tagesdaten-CSV liefert dabei ausschließlich einen Blick auf die Daten gemäß dem Stand des betrachteten Tages. Die Daten sind im situationsbedingten Kontext aufbereitet, damit sind verschiedene Tagesdaten-CSVs u.U. nicht direkt miteinander vergleichbar. Die aktuellsten Meldungen werden im gewählten Betrachtungszeitfenster über alle Meldebereiche und Standorte aufsummiert. Weitere Informationen sind zu finden unter https://www.intensivregister.de/#/faq
DOI: 10.5281/zenodo.4650407
title: Agile Success Model

description: Replication package for the paper: "The Agile Success Model: A Mixed Methods Study of a Large-Scale Agile Transformation"
DOI: 10.34840/pptd-vd90
title: Come for the looks, stay for the personality? A mixed methods investigation of reacquisition and owner recommendation of Bulldogs, French Bulldogs and Pugs
DOI: 10.5522/04/13726900
title: Data for the paper - Prognostic tools or clinical predictions: Which are better in palliative care?

description: This is an anonymised dataset from the PiPS2 study. It contains the data required to calculate the Palliative Prognostic (PaP) score; the Feliu Prognostic nomogram (FPN); the Palliative Performance Scale; and the Palliative Prognostic Index (PPI). It also includes clinicians' predictions of survival in varous formats and actual survival. The datset accompanies a publication in the journal PLOS ONE
DOI: 10.5522/04/13726900.v1
title: Data for the paper - Prognostic tools or clinical predictions: Which are better in palliative care?

description: This is an anonymised dataset from the PiPS2 study. It contains the data required to calculate the Palliative Prognostic (PaP) score; the Feliu Prognostic nomogram (FPN); the Palliative Performance Scale; and the Palliative Prognostic Index (PPI). It also includes clinicians' predictions of survival in varous formats and actual survival. The datset accompanies a publication in the journal PLOS ONE
DOI: 10.6084/m9.figshare.14346059
title: Supplementary Material for: The Prevalence of Allergic Rhinitis, its Triggers, and Associated Factors in Commonwealth of Independent States Countries (Ukraine, Kazakhstan, and Azerbaijan): Results of the CORE Study

description: <b><i>Background:</i></b> In the Commonwealth of Independent States (CIS) countries the epidemiology of allergic rhinitis (AR) is poorly characterized. The rationale and design of the CORE (Chronic Obstructive REspiratory diseases) study have been described elsewhere. <b><i>Methods:</i></b> A total of 2,842 adults (≥18 years) were recruited (964 in Kiev, Ukraine, 945 in Almaty, Kazakhstan, and 933 in Baku, Azerbaijan) between 2013 and 2015 and interviewed during household visits. Two-step cluster randomization was used for the sampling strategy. “Doctor-diagnosed AR” was considered when the respondent had previously been diagnosed with AR by a doctor, “self-reported AR symptoms” (was defined as watery runny nose during the last 12 months alone or in combination with any of the following: sneezing, nasal obstruction, nasal itching, or conjunctivitis). <b><i>Results:</i></b> The prevalence of doctor-diagnosed AR was 33.4, 92.1, and 82.7 per 1,000 persons, and the prevalence of self-reported AR symptoms was 44.7, 97.4, and 85.7 per 1,000 persons, in Ukraine, Kazakhstan, and Azerbaijan, respectively. In Ukraine, the peak of AR symptoms was in May, in Kazakhstan – in May–September, and in Azerbaijan in March–May. Sneezing and nasal congestion were the most frequent symptoms. Pollen as AR trigger was reported by 71.9% respondents in Ukraine, 70.1% in Kazakhstan, and 68.8% in Azerbaijan. Only 35–56% respondents with doctor diagnosed AR have had specific investigations (skin test, analysis for immunoglobulin etc.). The percent of subjects with chronic (nonrespiratory) health condition was higher in the respondents with self-reported AR symptoms compared to rest of the respondent: 100 versus 42% in Ukraine, 100 versus 21% in Kazakhstan, and 100 versus 50% in Azerbaijan, respectively. <b><i>Conclusion:</i></b> In CIS countries, the prevalence of self-reported AR symptoms was slightly higher than the prevalence of doctor-diagnosed AR. Compared to countries from other continents, the prevalence of doctor-diagnosed AR was similar; however, the prevalence of AR symptoms seems to be relatively lower.
DOI: 10.6084/m9.figshare.14346029
title: Supplementary Material for: Distinct Solute Removal Patterns by Similar Surface High-Flux Membranes in Haemodiafiltration: The Adsorption Point of View

description: <b><i>Introduction:</i></b> Haemodialysis (HD) allow depuration of uraemic toxins by diffusion, convection, and adsorption. Online haemodiafiltration (HDF) treatments add high convection to enhance removal. There are no prior studies on the relationship between convection and adsorption in HD membranes. The possible benefits conferred by intrinsic adsorption on protein-bound uraemic toxins (PBUTs) removal are unknown. <b><i>Methods:</i></b> Twenty-two patients underwent their second 3-days per week HD sessions with randomly selected haemodialysers (polysulfone, polymethylmethacrylate, cellulose triacetate, and polyamide copolymer) in high-flux HD and HDF. Blood samples were taken at the beginning and at the end of the treatment to assess the reduction ratio (RR) in a wide range of molecular weight uraemic toxins. A mid-range removal score (GRS) was also calculated. An elution protocol was implemented to quantify the amount of adsorbed mass (<i>M</i><sub>ads</sub>) for each molecule in every dialyser. <b><i>Results:</i></b> All synthetic membranes achieved higher RR for all toxins when used in HDF, specially the polysulfone haemodialyser, resulting in a GRS = 0.66 ± 0.06 (<i>p</i> &lt; 0.001 vs. cellulose triacetate and polyamide membranes). Adsorption was slightly enhanced by convection for all membranes. The polymethylmethacrylate membrane showed expected substantial adsorption of β<sub>2</sub>-microglobulin (<i>M</i><sub>ads</sub><sup>HDF</sup> = 3.5 ± 2.1 mg vs. <i>M</i><sub>ads</sub><sup>HD</sup> = 2.1 ± 0.9 mg, <i>p</i> = 0.511), whereas total protein adsorption was pronounced in the cellulose triacetate membrane (<i>M</i><sub>ads</sub><sup>HDF</sup> = 427.2 ± 207.9 mg vs. <i>M</i><sub>ads</sub><sup>HD</sup> = 274.7 ± 138.3 mg, <i>p</i> = 0.586) without enhanced PBUT removal. <b><i>Discussion/Conclusion:</i></b> Convection improves removal and slightly increases adsorption. Adsorbed proteins do not lead to enhanced PBUTs depuration and limit membrane efficiency due to fouling. Selection of the correct membrane for convective therapies is mandatory to optimize removal efficiency.
DOI: 10.48370/ofd/wsbgzm
title: Cladochytrium menyanthis (de Bary) de Bary, 944

description: Fungarium Mikromycetes
DOI: 10.6084/m9.figshare.14346104
title: Supplementary Material for: Melanoma of the Nail Apparatus: An Analysis of Patients’ Survival and Associated Factors

description: <b><i>Background:</i></b> There are no proper management guidelines for nail apparatus melanoma (NAM). <b><i>Objective:</i></b> This study aimed to describe the clinical features, the presence of locoregional and distant metastases and disease-free and overall survival of NAM treated at our institution. <b><i>Methods:</i></b> A retrospective cohort review of patients with single, primary localized histopathologically confirmed NAM was performed. Collected data consisted of patients’ characteristics and tumor features. In addition, local recurrence, locoregional metastases, distant metastases, disease-free survival (DFS) and overall survival (OS) were used as the main outcomes in our analysis. <b><i>Results:</i></b> Thirty patients with NAM were included. The overall survival (OS) in our patients at 5 and 10 years was 85.6 and 73.4%, respectively. DFS was significantly higher in patients with primary tumor location in the hand and without tumor-infiltrating lymphocytes (<i>p</i> value = 0.01 and 0.04, respectively). The patients with in situ melanoma or Breslow thickness &lt;1 mm had a significantly higher chance of DFS and OS (90.0 and 94.1% at 5 years, respectively) than those with thicker NAM (58.3 and 55.6% at 5 years, respectively). A total of 53.3% of 30 patients underwent primary excision and covering with a full-thickness skin graft, while 13.3% of our 30 patients underwent digit amputation. The patients who underwent excision and covering with a full-thickness skin graft showed a complete overall survival (100% at 5 years). <b><i>Conclusion:</i></b> Primary tumor location in the hand and lower tumor thickness might be correlated with better patients’ survival. The study results suggest that total amputation might not be necessary in all NAM cases.
DOI: 10.5255/ukda-sn-854785
title: Political Agreements in Internal Conflicts, 1989-2016

description: The dataset of Political Agreements in Internal Conflicts (PAIC) captures the institutional provisions in political agreements concluded between 1989 and 2016. It provides information on 91 variables, along five dimensions: power sharing, transitional justice, cultural institutions, territorial self-governance and international assistance.
DOI: 10.7910/dvn/tuok8y
title: Replication Data for: The Arbitrage Lobby: Theory and Evidence on Dual Exchange Rates

description: Foundational theories of trade politics emphasize a conflict between consumer welfare and protectionist lobbies. But these theories ignore other powerful lobbies that also shape trade policy. We propose a theory of trade distortion arising from conflict between consumer welfare and importer lobbies. We estimate the key parameter of the model—the government’s weight on welfare—using original data from Venezuela, where Hugo Chávez used an exchange-rate subsidy to underwrite hundreds of billions of dollars of imports. Whereas estimates from traditional models would make Chávez look like a welfare maximizer, our results indicate that he implemented distortionary commercial policy to the benefit of special interests. Our analysis underscores the importance of tailoring workhorse models to account for differences in interest group configuration. The politics of trade policy is not reducible to the politics of protectionism.
DOI: 10.21227/f49x-tt23
title: Day-Ahead Forecasting using LSTM with rolling windows

description: The project involves day-ahead forecasting which takes a model fit into historical data and predicts future demand of electricity. Time series forecasting methods are used as the dataset contains an explicit order dependence between observations, i.e. a time dimension which makes the problem difficult to handle but makes the prediction more accurate. Various machine learning and deep learning algorithms were used to accomplish this work. Results obtained by autoregressive integrated moving average(ARIMA), autoregressive moving average with explanatory variable(ARIMAX), seasonal autoregressive moving average(SARIMA), seasonal autoregressive moving average(SARIMAX) and long short term memory(LSTM) recurrent neural networks with rolling windows were compared and the one with least error, i.e. LSTM with rolling windows was used for time series prediction.
DOI: 10.5517/ccdc.csd.cc26j182
title: CCDC 2041203: Experimental Crystal Structure Determination

description: Related Article: Shun Kimura, Motoyuki Uejima, Wataru Ota, Tohru Sato, Shinpei Kusakag, Ryotaro Matsudag, Hiroshi Nishiharah, Tetsuro Kusamotoij|2021|J.Am.Chem.Soc.|143|4329|doi:10.1021/jacs.0c13310
DOI: 10.5517/ccdc.csd.cc26ldpx
title: CCDC 2043479: Experimental Crystal Structure Determination

description: Related Article: Liang-Liang Gao, Bei-Bei Wang, Xi Chen, Yuan Wang, Wei-Na Wu, Xiao-Lei Zhao, Ling-Ling Yan, Yun-Chang Fan, Zhi-Hong Xu|2021|Spectrochim.Acta,Part A|255|119693|doi:10.1016/j.saa.2021.119693
DOI: 10.5517/ccdc.csd.cc26ldrz
title: CCDC 2043481: Experimental Crystal Structure Determination

description: Related Article: Liang-Liang Gao, Bei-Bei Wang, Xi Chen, Yuan Wang, Wei-Na Wu, Xiao-Lei Zhao, Ling-Ling Yan, Yun-Chang Fan, Zhi-Hong Xu|2021|Spectrochim.Acta,Part A|255|119693|doi:10.1016/j.saa.2021.119693
DOI: 10.5517/ccdc.csd.cc26pr1q
title: CCDC 2046683: Experimental Crystal Structure Determination

description: Related Article: A.V. Chernyshev, E.V. Solov’eva, N.A. Voloshin, O.P. Demidov, E.B. Gaeva, A.S. Nepomnyashiy, A.V. Metelitsa|2021|J.Photochem.Photobiol.A:Chem.|413|113259|doi:10.1016/j.jphotochem.2021.113259
DOI: 10.5517/ccdc.csd.cc26ryqn
title: CCDC 2048812: Experimental Crystal Structure Determination

description: Related Article: Shun Kimura, Motoyuki Uejima, Wataru Ota, Tohru Sato, Shinpei Kusakag, Ryotaro Matsudag, Hiroshi Nishiharah, Tetsuro Kusamotoij|2021|J.Am.Chem.Soc.|143|4329|doi:10.1021/jacs.0c13310
DOI: 10.5517/ccdc.csd.cc21mh17
title: CCDC 1895558: Experimental Crystal Structure Determination

description: Related Article: Muhammad Naeem Ahmed, Sadia Shabbir, Bakhtawar Batool, Tariq Mahmood, Umer Rashid, Khawaja Ansar Yasin, Muhammad Nawaz Tahir, M. L. Arias Cassará, Diego M. Gil|2021|J.Mol.Struct.|1236|130283|doi:10.1016/j.molstruc.2021.130283
DOI: 10.48370/ofd/ucl8at
title: Cladosporium exobasidii Japp, 4425

description: Fungarium Mikromycetes
DOI: 10.21227/cvwp-qv96
title: Forecast for February 02

description: Forecast for February 02
DOI: 10.48370/ofd/xi5t4x
title: Cladosporium iridis (Fautrey Roumeguere) de Vries, 1528

description: Fungarium Mikromycetes