cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.31056901
title: <b>Identification and profiling of HLA-A*02:01-restricted Toxoplasma gondii peptides through immunopeptidomics in HLA-A2.1 transgenic mice</b>

description: HLA class I presentation of pathogen-derived peptides is essential for CD8+ T-cell recognition of <i>Toxoplasma gondii</i>. While <i>in vitro</i> MHC ligands have been documented, the <i>in vivo</i> epitope landscape during infection progression remains poorly characterized. Here, we employed an MS-based immunopeptidomics approach to directly profile the <i>T. gondii</i> immunopeptidome presented by HLA-A*02:01 in transgenic mice. Our analysis identified a comprehensive repertoire of 3,744 MHC-I ligands originating from diverse parasite proteins, including a substantial proportion of previously uncharacterized hypothetical proteins. Notably, specific ligands were consistently detected across both acute and chronic stages, suggesting that conserved functional domains may drive MHC-I epitope selection throughout the infection cycle. By integrating <i>in silico</i> predictions with experimental validation, we identified 72 high-affinity candidates, five of which exhibited robust binding capacity <i>in vitro</i> and <i>in vivo</i>. Specifically, we identified glycogen synthase as a novel dominant antigen, yielding a high-affinity ligand (designated PGS) with a favorable HLA-A*02:01 binding architecture. These findings significantly expand the known HLA-A*02:01-restricted antigen landscape of <i>T. gondii</i> and provide critical molecular targets for the rational design of next-generation vaccines against both acute and chronic toxoplasmosis.
DOI: 10.6084/m9.figshare.31056901.v7
title: <b>Identification and profiling of HLA-A*02:01-restricted Toxoplasma gondii peptides through immunopeptidomics in HLA-A2.1 transgenic mice</b>

description: HLA class I presentation of pathogen-derived peptides is essential for CD8+ T-cell recognition of <i>Toxoplasma gondii</i>. While <i>in vitro</i> MHC ligands have been documented, the <i>in vivo</i> epitope landscape during infection progression remains poorly characterized. Here, we employed an MS-based immunopeptidomics approach to directly profile the <i>T. gondii</i> immunopeptidome presented by HLA-A*02:01 in transgenic mice. Our analysis identified a comprehensive repertoire of 3,744 MHC-I ligands originating from diverse parasite proteins, including a substantial proportion of previously uncharacterized hypothetical proteins. Notably, specific ligands were consistently detected across both acute and chronic stages, suggesting that conserved functional domains may drive MHC-I epitope selection throughout the infection cycle. By integrating <i>in silico</i> predictions with experimental validation, we identified 72 high-affinity candidates, five of which exhibited robust binding capacity <i>in vitro</i> and <i>in vivo</i>. Specifically, we identified glycogen synthase as a novel dominant antigen, yielding a high-affinity ligand (designated PGS) with a favorable HLA-A*02:01 binding architecture. These findings significantly expand the known HLA-A*02:01-restricted antigen landscape of <i>T. gondii</i> and provide critical molecular targets for the rational design of next-generation vaccines against both acute and chronic toxoplasmosis.
DOI: 10.6084/m9.figshare.31056901.v6
title: <b>Identification and profiling of HLA-A*02:01-restricted Toxoplasma gondii peptides through immunopeptidomics in HLA-A2.1 transgenic mice</b>

description: HLA class I presentation of pathogen-derived peptides is essential for CD8+ T-cell recognition of <i>Toxoplasma gondii</i>. While <i>in vitro</i> MHC ligands have been documented, the <i>in vivo</i> epitope landscape during infection progression remains poorly characterized. Here, we employed an MS-based immunopeptidomics approach to directly profile the <i>T. gondii</i> immunopeptidome presented by HLA-A*02:01 in transgenic mice. Our analysis identified a comprehensive repertoire of 3,744 MHC-I ligands originating from diverse parasite proteins, including a substantial proportion of previously uncharacterized hypothetical proteins. Notably, specific ligands were consistently detected across both acute and chronic stages, suggesting that conserved functional domains may drive MHC-I epitope selection throughout the infection cycle. By integrating <i>in silico</i> predictions with experimental validation, we identified 72 high-affinity candidates, five of which exhibited robust binding capacity <i>in vitro</i> and <i>in vivo</i>. Specifically, we identified glycogen synthase as a novel dominant antigen, yielding a high-affinity ligand (designated PGS) with a favorable HLA-A*02:01 binding architecture. These findings significantly expand the known HLA-A*02:01-restricted antigen landscape of <i>T. gondii</i> and provide critical molecular targets for the rational design of next-generation vaccines against both acute and chronic toxoplasmosis.
DOI: 10.15468/dl.692hha
title: Occurrence Download

description: A dataset containing 6422 records in GBIF matching the query:
SELECT
 '2' AS fish_cell,
 GBIF_MGRSCode(1000, decimalLatitude, decimalLongitude, 0) AS cell, -- NO randomization
 COUNT(DISTINCT speciesKey) AS species_richness
 FROM occurrence
 WHERE hasCoordinate = TRUE
 AND speciesKey IS NOT NULL
 AND NOT ARRAY_CONTAINS(issue, 'ZERO_COORDINATE')
 AND NOT ARRAY_CONTAINS(issue, 'COORDINATE_OUT_OF_RANGE')
 AND NOT ARRAY_CONTAINS(issue, 'COORDINATE_INVALID')
 AND NOT ARRAY_CONTAINS(issue, 'COUNTRY_COORDINATE_MISMATCH')
 AND decimalLatitude &gt;= -51.21395264452012
 AND decimalLatitude &lt;= -46.479780028101516
 AND decimalLongitude &gt;= -73.49581818030033
 AND decimalLongitude &lt;= -62.94398091796209
 AND "year" &gt;= 2015
 AND "year" &lt;= 2026
 AND (coordinateUncertaintyInMeters &lt;= 100 OR coordinateUncertaintyInMeters IS NULL)
 GROUP BY fish_cell, cell

 The dataset's 6422 records were derived from 54 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0002458-260120142942310/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.qfgzbn
title: Occurrence Download

description: A dataset containing 127969 species occurrences available in GBIF matching the query:
{
 "and" : [
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 "TaxonKey is Monotremata"
 ]
}

 The dataset includes 127969 records from 84 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0002440-260120142942310/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.6084/m9.figshare.28722946
title: Effective thermal management of photovoltaic modules equipped with innovative concentrating techniques

description: Due to growing apprehension about energy density in Photovoltaics (PV), researchers have proposed multiple concentrators and thermal-management techniques. In the present study, based on system operation and power output, two designs are proposed: compound parabolic collector (CPC) based PV (PV-CPC) and Fresnel lens-based PV (PV-FNL). A gravity-assisted evaporative cooling system in PV-CPC resulted in 7.1 ℃ to 11.2 ℃ temperature drop, which led to 13.1% to 26.1% improvement in power output. A higher fill factor (0.72 compared to 0.65 for reference model) also complements the system design, which had minimum tracking. Further, owing to both electrical and thermal outputs, the PV-FNL model is suggested, which had an effective forced cooling. Significant improvement in module power output (46% to 59%) followed by useful heat gain (500 W with water exit temperature as ≈ 95 ℃) upholds the efficacy of the proposed system. However, the low fill factor (0.49) indicates an additional cooling requirement. Though the results are promising, enviroeconomic and life cycle analysis of PV-CPC and PV-FNL is worth gauging for in-field applications. Even, in PV-FNL configuration, the multi-junction cell-based module and CPC integrated thermal receiver can fetch better and more reliable results.
DOI: 10.6084/m9.figshare.28722946.v1
title: Effective thermal management of photovoltaic modules equipped with innovative concentrating techniques

description: Due to growing apprehension about energy density in Photovoltaics (PV), researchers have proposed multiple concentrators and thermal-management techniques. In the present study, based on system operation and power output, two designs are proposed: compound parabolic collector (CPC) based PV (PV-CPC) and Fresnel lens-based PV (PV-FNL). A gravity-assisted evaporative cooling system in PV-CPC resulted in 7.1 ℃ to 11.2 ℃ temperature drop, which led to 13.1% to 26.1% improvement in power output. A higher fill factor (0.72 compared to 0.65 for reference model) also complements the system design, which had minimum tracking. Further, owing to both electrical and thermal outputs, the PV-FNL model is suggested, which had an effective forced cooling. Significant improvement in module power output (46% to 59%) followed by useful heat gain (500 W with water exit temperature as ≈ 95 ℃) upholds the efficacy of the proposed system. However, the low fill factor (0.49) indicates an additional cooling requirement. Though the results are promising, enviroeconomic and life cycle analysis of PV-CPC and PV-FNL is worth gauging for in-field applications. Even, in PV-FNL configuration, the multi-junction cell-based module and CPC integrated thermal receiver can fetch better and more reliable results.
DOI: 10.15468/dl.z48cxn
title: Occurrence Download

description: A dataset containing 382 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is Nepal",
 "OccurrenceStatus is Present",
 "TaxonKey is Felis chaus"
 ]
}

 The dataset includes 382 records from 10 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0002482-260120142942310/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.3886/e244521v1
title: Clifford University, Abia State, 2026/2027 ADMISSION FORM is out call 09031383306 DR MR JAMES (+249031383306) for TRANSCRIPT Collection School Admin Line 09031383306 To apply Also 2026/2027 Nursing form

description: Clifford University, Abia State, 2026/2027 ADMISSION FORM is out call 09031383306 DR MR JAMES (+249031383306) for TRANSCRIPT Collection School Admin Line 09031383306 To apply Also 2026/2027 Nursing form
DOI: 10.5281/zenodo.17543024
title: Modelling of phytoplankton-zooplankton dynamics under environmental change in a temperate dimictic reservoir
DOI: 10.15468/dl.vme9jw
title: Occurrence Download

description: A dataset containing 565 species occurrences available in GBIF matching the query:
{
 "and" : [
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 "TaxonKey is Notoryctemorphia"
 ]
}

 The dataset includes 565 records from 14 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0002481-260120142942310/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.6084/m9.figshare.29042112
title: Long-term global trends and influencing factors of surface urban cool and heat islands

description: Global warming and urbanization have intensified temperature differences (ΔT) between urban and nonurban areas, creating distinct surface urban heat islands (SUHIs) and surface urban cool islands (SUCIs). This study analyzes SUHI and SUCI trends across 1,963 global cities from 2001 to 2018, exploring their spatiotemporal patterns and drivers. Pearson correlation analysis was used to examine the relationships between ΔT and key factors, including the enhanced vegetation index (EVI), proportion of impervious surface (PIS), and climatic variables such as precipitation (PR), surface downwelling shortwave radiation (RSDS), mean daily air temperature (TAS), near-surface wind speed (Sfc Wind), near-surface relative humidity (HURS), and potential evapotranspiration (PET). Key findings include: (1) SUCIs are more common in winter but most significant in summer, with daytime SUCIs transitioning to nighttime SUHIs; (2) SUHI cities show a ΔT increase of 0.153°C per decade (<i>P</i> &lt; 0.01), while SUCI cities show a decrease of −0.102°C per decade (<i>P</i> &lt; 0.01); (3) HURS is the dominant climatic driver, with PR and RSDS more influential in summer, and TAS being crucial in winter. Future research should explore the dynamic interactions between climate and human factors in shaping ΔT for adaptive urban planning.
DOI: 10.6084/m9.figshare.29042112.v1
title: Long-term global trends and influencing factors of surface urban cool and heat islands

description: Global warming and urbanization have intensified temperature differences (ΔT) between urban and nonurban areas, creating distinct surface urban heat islands (SUHIs) and surface urban cool islands (SUCIs). This study analyzes SUHI and SUCI trends across 1,963 global cities from 2001 to 2018, exploring their spatiotemporal patterns and drivers. Pearson correlation analysis was used to examine the relationships between ΔT and key factors, including the enhanced vegetation index (EVI), proportion of impervious surface (PIS), and climatic variables such as precipitation (PR), surface downwelling shortwave radiation (RSDS), mean daily air temperature (TAS), near-surface wind speed (Sfc Wind), near-surface relative humidity (HURS), and potential evapotranspiration (PET). Key findings include: (1) SUCIs are more common in winter but most significant in summer, with daytime SUCIs transitioning to nighttime SUHIs; (2) SUHI cities show a ΔT increase of 0.153°C per decade (<i>P</i> &lt; 0.01), while SUCI cities show a decrease of −0.102°C per decade (<i>P</i> &lt; 0.01); (3) HURS is the dominant climatic driver, with PR and RSDS more influential in summer, and TAS being crucial in winter. Future research should explore the dynamic interactions between climate and human factors in shaping ΔT for adaptive urban planning.
DOI: 10.6084/m9.figshare.31054993
title: Source data of "Identification of a mechanical signaling pathway activating type 1 fimbriae via a ZraSR two-component system in neonatal meningitis-associated <i>Escherichia coli</i>"

description: <i>Escherichia coli </i>K1 (<i>E. coli</i> K1) meningitis develops after the bacteria cross the blood-brain barrier (BBB), however, the molecular mechanisms underlying this process remain incompletely understood. Adhesion to human brain microvascular endothelial cells (HBMECs), which constitute the BBB is considered important in <i>E. coli</i> K1 bacterial penetration into the central nervous system. Here, we report a complete signal regulatory pathway in which the ZraSR two-component system (TCS) senses mechanical stimuli induced by initial host cell attachment and directly activates the expression of type 1 fimbriae, specifically the FimH adhesin. This activation enhances <i>E. coli</i> K1 invasion into HBMECs. Disruption of this signaling pathway severely attenuates the progression of meningitis and reduces the production of proinflammatory factors triggered by <i>E. coli</i> K1 infection <i>in vivo</i>. These findings suggest that components of this pathway may serve as potential targets for novel therapeutic strategies against <i>E. coli</i> K1 infection.
DOI: 10.6084/m9.figshare.24886562
title: Exogenous abscisic acid treatment regulates protein secretion in sorghum cell suspension cultures

description: Drought stress adversely affects plant growth, often leading to total crop failure. Upon sensing soil water deficits, plants switch on biosynthesis of abscisic acid (ABA), a stress hormone for drought adaptation. Here, we used exogenous ABA application to dark-grown sorghum cell suspension cultures as an experimental system to understand how a drought-tolerant crop responds to ABA. We evaluated intracellular and secreted proteins using isobaric tags for relative and absolute quantification. While the abundance of only ~ 7% (46 proteins) intracellular proteins changed in response to ABA, ~32% (82 proteins) of secreted proteins identified in this study were ABA responsive. This shows that the extracellular matrix is disproportionately targeted and suggests it plays a vital role in sorghum adaptation to drought. Extracellular proteins responsive to ABA were predominantly defense/detoxification and cell wall-modifying enzymes. We confirmed that sorghum plants exposed to drought stress activate genes encoding the same proteins identified in the <i>in vitro</i> cell culture system with ABA. Our results suggest that ABA activates defense and cell wall remodeling systems during stress response. This could underpin the success of sorghum adaptation to drought stress.
DOI: 10.6084/m9.figshare.24886562.v1
title: Exogenous abscisic acid treatment regulates protein secretion in sorghum cell suspension cultures

description: Drought stress adversely affects plant growth, often leading to total crop failure. Upon sensing soil water deficits, plants switch on biosynthesis of abscisic acid (ABA), a stress hormone for drought adaptation. Here, we used exogenous ABA application to dark-grown sorghum cell suspension cultures as an experimental system to understand how a drought-tolerant crop responds to ABA. We evaluated intracellular and secreted proteins using isobaric tags for relative and absolute quantification. While the abundance of only ~ 7% (46 proteins) intracellular proteins changed in response to ABA, ~32% (82 proteins) of secreted proteins identified in this study were ABA responsive. This shows that the extracellular matrix is disproportionately targeted and suggests it plays a vital role in sorghum adaptation to drought. Extracellular proteins responsive to ABA were predominantly defense/detoxification and cell wall-modifying enzymes. We confirmed that sorghum plants exposed to drought stress activate genes encoding the same proteins identified in the <i>in vitro</i> cell culture system with ABA. Our results suggest that ABA activates defense and cell wall remodeling systems during stress response. This could underpin the success of sorghum adaptation to drought stress.
DOI: 10.6084/m9.figshare.31054993.v1
title: Source data of "Identification of a mechanical signaling pathway activating type 1 fimbriae via a ZraSR two-component system in neonatal meningitis-associated <i>Escherichia coli</i>"

description: <i>Escherichia coli </i>K1 (<i>E. coli</i> K1) meningitis develops after the bacteria cross the blood-brain barrier (BBB), however, the molecular mechanisms underlying this process remain incompletely understood. Adhesion to human brain microvascular endothelial cells (HBMECs), which constitute the BBB is considered important in <i>E. coli</i> K1 bacterial penetration into the central nervous system. Here, we report a complete signal regulatory pathway in which the ZraSR two-component system (TCS) senses mechanical stimuli induced by initial host cell attachment and directly activates the expression of type 1 fimbriae, specifically the FimH adhesin. This activation enhances <i>E. coli</i> K1 invasion into HBMECs. Disruption of this signaling pathway severely attenuates the progression of meningitis and reduces the production of proinflammatory factors triggered by <i>E. coli</i> K1 infection <i>in vivo</i>. These findings suggest that components of this pathway may serve as potential targets for novel therapeutic strategies against <i>E. coli</i> K1 infection.
DOI: 10.6084/m9.figshare.31054993.v2
title: Source data of "Identification of a mechanical signaling pathway activating type 1 fimbriae via a ZraSR two-component system in neonatal meningitis-associated <i>Escherichia coli</i>"

description: <i>Escherichia coli </i>K1 (<i>E. coli</i> K1) meningitis develops after the bacteria cross the blood-brain barrier (BBB), however, the molecular mechanisms underlying this process remain incompletely understood. Adhesion to human brain microvascular endothelial cells (HBMECs), which constitute the BBB is considered important in <i>E. coli</i> K1 bacterial penetration into the central nervous system. Here, we report a complete signal regulatory pathway in which the ZraSR two-component system (TCS) senses mechanical stimuli induced by initial host cell attachment and directly activates the expression of type 1 fimbriae, specifically the FimH adhesin. This activation enhances <i>E. coli</i> K1 invasion into HBMECs. Disruption of this signaling pathway severely attenuates the progression of meningitis and reduces the production of proinflammatory factors triggered by <i>E. coli</i> K1 infection <i>in vivo</i>. These findings suggest that components of this pathway may serve as potential targets for novel therapeutic strategies against <i>E. coli</i> K1 infection.
DOI: 10.3886/e244532v1
title: College of Nursing Sciences, Adazi-Nnukwu, Anambra State, 2026/2027 ADMISSION FORM is out call 09031383306 DR MR JAMES (+249031383306) for TRANSCRIPT Collection School Admin Line 09031383306 To apply Also 2026/2027 Nursing form

description: College of Nursing Sciences, Adazi-Nnukwu, Anambra State, 2026/2027 ADMISSION FORM is out call 09031383306 DR MR JAMES (+249031383306) for TRANSCRIPT Collection School Admin Line 09031383306 To apply Also 2026/2027 Nursing form
DOI: 10.3886/e244531v1
title: College of Nursing Sciences, Eket, Akwa Ibom State, 2026/2027 ADMISSION FORM is out call 09031383306 DR MR JAMES (+249031383306) for TRANSCRIPT Collection School Admin Line 09031383306 To apply Also 2026/2027 Nursing form

description: College of Nursing Sciences, Eket, Akwa Ibom State, 2026/2027 ADMISSION FORM is out call 09031383306 DR MR JAMES (+249031383306) for TRANSCRIPT Collection School Admin Line 09031383306 To apply Also 2026/2027 Nursing form
DOI: 10.3886/e244530v1
title: College of Nursing Sciences, Ikot-Ekpene, Akwa Ibom State, 2026/2027 ADMISSION FORM is out call 09031383306 DR MR JAMES (+249031383306) for TRANSCRIPT Collection School Admin Line 09031383306 To apply Also 2026/2027 Nursing form

description: College of Nursing Sciences, Ikot-Ekpene, Akwa Ibom State, 2026/2027 ADMISSION FORM is out call 09031383306 DR MR JAMES (+249031383306) for TRANSCRIPT Collection School Admin Line 09031383306 To apply Also 2026/2027 Nursing form
DOI: 10.3886/e244529v1
title: College of Nursing Sciences, Iquita-Oron, Akwa Ibom State, 2026/2027 ADMISSION FORM is out call 09031383306 DR MR JAMES (+249031383306) for TRANSCRIPT Collection School Admin Line 09031383306 To apply Also 2026/2027 Nursing form

description: College of Nursing Sciences, Iquita-Oron, Akwa Ibom State, 2026/2027 ADMISSION FORM is out call 09031383306 DR MR JAMES (+249031383306) for TRANSCRIPT Collection School Admin Line 09031383306 To apply Also 2026/2027 Nursing form
DOI: 10.3886/e244527v1
title: College of Nursing Sciences, Anua-Uyo, Akwa Ibom State, 2026/2027 ADMISSION FORM is out call 09031383306 DR MR JAMES (+249031383306) for TRANSCRIPT Collection School Admin Line 09031383306 To apply Also 2026/2027 Nursing form

description: College of Nursing Sciences, Anua-Uyo, Akwa Ibom State, 2026/2027 ADMISSION FORM is out call 09031383306 DR MR JAMES (+249031383306) for TRANSCRIPT Collection School Admin Line 09031383306 To apply Also 2026/2027 Nursing form