cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.5281/zenodo.7541452
title: Dataset related to the article "Reprogramming of dermal fibroblasts from a Duchenne muscular dystrophy patient carrying a deletion of exons 45–50 into an induced pluripotent stem cell line (CCMi005-A)"

description: This record contains raw data related to the article " "Reprogramming of dermal fibroblasts from a Duchenne muscular dystrophy patient carrying a deletion of exons 45–50 into an induced pluripotent stem cell line (CCMi005-A)" Abstract Duchenne muscular dystrophy (DMD) is an X-linked syndrome that affects skeletal and cardiac muscle and is caused by mutation of the dystrophin gene. Induced pluripotent stem cells (iPSCs) were generated from dermal fibroblasts by electroporation with episomal vectors containing the reprogramming factors (OCT4, SOX2, LIN28, KLF4, and L-MYC). The donor carried an out-of-frame deletion of exons 45–50 of the dystrophin gene. The established iPSC line exhibited normal morphology, expressed pluripotency markers, had normal karyotype and possessed trilineage differentiation potential.
description: Founding: Fondazione IEO-CCM; Italian Ministry of Health-Ricerca Corrente MPP5A: Advanced cell models of cardiomyopathies; Fondazione Umberto Veronesi; Telethon-Unione Italiana Lotta alla Distrofia Muscolare Clinical Projects 2019 GUP19012
DOI: 10.6084/m9.figshare.21856590.v1
title: Supplementary Material for: Association of Torquetenovirus viremia with physical frailty and cognitive impairment in three independent European cohorts

description: Introduction: Immunosenescence and inflammaging have been implicated in the pathophysiology of frailty. Torquetenovirus (TTV), a single-stranded DNA anellovirus, the major component of the human blood virome, shows an increased replication rate with advancing age. An elevated TTV viremia has been associated with an impaired immune function and an increased risk of mortality in the older population. The objective of this study was to analyze the relation between TTV viremia, physical frailty and cognitive impairment Methods: TTV viremia was measured in 1131 nonfrail, 45 physically frail, and 113 cognitively impaired older adults recruited in the MARK-AGE study (overall mean age 64.7±5.9 years), then the results were checked in two other independent cohorts from Spain and Portugal, including 126 frail, 252 prefrail and 141 nonfrail individuals (overall mean age: 77.5±8.3 years). Results: TTV viremia ≥4log was associated with physical frailty (OR: 4.69; 95% CI: 2.06-10.67, p&lt;0.0001) and cognitive impairment (OR: 3.49, 95% CI : 2.14-5.69, p&lt;0.0001) in the MARK-AGE population. The association between TTV DNA load and frailty status was confirmed in the Spanish cohort, while a slight association with cognitive impairment was observed (OR: 1.33; 95% CI: 1.000-1.773), only in the unadjusted model. No association between TTV load and frailty or cognitive impairment was found in the Portuguese sample, although a negative association between TTV viremia and MMSE score was observed in Spanish and Portuguese females. Conclusions: These findings demonstrate an association between TTV viremia and physical frailty, while the association with cognitive impairment was observed only in the younger population from the MARK-AGE study. Further research is necessary to clarify TTV's clinical relevance in the onset and progression of frailty and cognitive decline in older individuals.
DOI: 10.6084/m9.figshare.21701645.v1
title: Data for Caves & Kelley: Proportional processing of a visual mate choice signal in the green swordtail, Xiphophorus hellerii

description: Data from experimental trials on female green swordtails Xiphophorus hellerii.
DOI: 10.6084/m9.figshare.21941213.v1
title: protocols_hms_to_unraveledTFs.tsv

description: Guide which TF can be found in which HM or protocol (ChIP-seq, ATAC-seq, DNAse-seq)
DOI: 10.2908/env_wastrd
title: Trade in recyclable raw materials by waste
title: Commerce des matières premières recyclables par déchets
title: Handel mit recycelbaren Rohstoffen nach Abfall
DOI: 10.2908/nrg_ind_331a
title: Market share of the largest generator in the electricity market - annual data
title: Part de marché du plus grand producteur d'électricité - données annuelles
title: Marktanteil des größten Erzeugers im Strommarkt - jährliche Daten
DOI: 10.6084/m9.figshare.21946505
title: merged_nodups.txt.gz

description: example .hic format file from HIC-seq data
DOI: 10.5281/zenodo.7564761
title: Alterations of the Sialylation Machinery in Brugada Syndrome

description: Ghiroldi A, Ciconte G, Creo P, Tarantino A, Melgari D, D'Imperio S, Piccoli M, Cirillo F, Micaglio E, Monasky MM, Frosio A, Locati ET, Vicedomini G, Rivolta I, Pappone C, Anastasia L. Alterations of the Sialylation Machinery in Brugada Syndrome. Int J Mol Sci. 2022 Oct 29;23(21):13154. doi: 10.3390/ijms232113154. PMID: 36361941; PMCID: PMC9655504. Brugada Syndrome (BrS) is an inherited arrhythmogenic disorder with an increased risk of sudden cardiac death. Recent evidence suggests that BrS should be considered as an oligogenic or polygenic condition. Mutations in genes associated with BrS are found in about one-third of patients and they mainly disrupt the cardiac sodium channel NaV1.5, which is considered the main cause of the disease. However, voltage-gated channel's activity could be impacted by post-translational modifications such as sialylation, but their role in BrS remains unknown. Thus, we analyzed high risk BrS patients (<em>n</em> = 42) and healthy controls (<em>n</em> = 42) to assess an involvement of sialylation in BrS. Significant alterations in gene expression and protein sialylation were detected in Peripheral Blood Mononuclear Cells (PBMCs) from BrS patients. These changes were significantly associated with the phenotypic expression of the disease, as the size of the arrhythmogenic substrate and the duration of epicardial electrical abnormalities. Moreover, protein desialylation caused a reduction in the sodium current in an in vitro NaV1.5-overexpressing model. Dysregulation of the sialylation machinery provides definitive evidence that BrS affects extracardiac tissues, suggesting an underlying cause of the disease. Moreover, detection of these changes at the systemic level and their correlation with the clinical phenotype hint at the existence of a biomarker signature for BrS.
DOI: 10.5281/zenodo.7564760
title: Alterations of the Sialylation Machinery in Brugada Syndrome

description: Ghiroldi A, Ciconte G, Creo P, Tarantino A, Melgari D, D'Imperio S, Piccoli M, Cirillo F, Micaglio E, Monasky MM, Frosio A, Locati ET, Vicedomini G, Rivolta I, Pappone C, Anastasia L. Alterations of the Sialylation Machinery in Brugada Syndrome. Int J Mol Sci. 2022 Oct 29;23(21):13154. doi: 10.3390/ijms232113154. PMID: 36361941; PMCID: PMC9655504. Brugada Syndrome (BrS) is an inherited arrhythmogenic disorder with an increased risk of sudden cardiac death. Recent evidence suggests that BrS should be considered as an oligogenic or polygenic condition. Mutations in genes associated with BrS are found in about one-third of patients and they mainly disrupt the cardiac sodium channel NaV1.5, which is considered the main cause of the disease. However, voltage-gated channel's activity could be impacted by post-translational modifications such as sialylation, but their role in BrS remains unknown. Thus, we analyzed high risk BrS patients (<em>n</em> = 42) and healthy controls (<em>n</em> = 42) to assess an involvement of sialylation in BrS. Significant alterations in gene expression and protein sialylation were detected in Peripheral Blood Mononuclear Cells (PBMCs) from BrS patients. These changes were significantly associated with the phenotypic expression of the disease, as the size of the arrhythmogenic substrate and the duration of epicardial electrical abnormalities. Moreover, protein desialylation caused a reduction in the sodium current in an in vitro NaV1.5-overexpressing model. Dysregulation of the sialylation machinery provides definitive evidence that BrS affects extracardiac tissues, suggesting an underlying cause of the disease. Moreover, detection of these changes at the systemic level and their correlation with the clinical phenotype hint at the existence of a biomarker signature for BrS.
DOI: 10.2908/isoc_ci_eu_en2
title: Summary of EU aggregates
title: Résumé des agrégats UE
title: Zusammenfassung der EU Aggregate
DOI: 10.2908/isoc_ec_wsobs_n2
title: Obstacles pour la vente via un site web, par activité de la NACE Rév. 2
title: Hinderungsgründe für Verkäufe über eine Website, nach Aktivitäten der NACE Rev.2
title: Obstacles for web sales by NACE Rev.2 activity
DOI: 10.57745/b3fhbq
title: FX17_sanded_se.zip
DOI: 10.57745/ot94r3
title: FX10_sanded_se.zip
DOI: 10.57745/hhk0ox
title: FX10_raw_se.zip
DOI: 10.57745/onhg5m
title: FX17_raw_le.zip

description: :unav
DOI: 10.57745/qjybvn
title: FX17_raw_se.zip

description: :unav
DOI: 10.57745/dvhdmh
title: FX17_sanded_le.zip

description: :unav
DOI: 10.57745/f88ocp
title: FX10_sanded_le.zip

description: :unav
DOI: 10.57745/i8eofu
title: FX10_raw_le_1.zip

description: :unav
DOI: 10.57745/26lzce
title: FX10_raw_le_2.zip

description: :unav
DOI: 10.57745/ufj0q9
title: wood_density_calibrated.zip

description: :unav
DOI: 10.57745/im4z1f
title: dicom.zip

description: :unav
DOI: 10.57745/0zbrtx
title: Corcieux_Lumix.zip

description: :unav
DOI: 10.57745/cii7ci
title: Munich_Canon.zip

description: :unav
DOI: 10.57745/5dzwgv
title: Corcieux_Huawei.zip

description: :unav
DOI: 10.57745/e0pwc8
title: Freiburg_Huawei.zip

description: :unav
DOI: 10.57745/tjmepw
title: tif.zip

description: :unav
DOI: 10.57745/dej57k
title: segmented.zip

description: :unav
DOI: 10.57745/28oe4x
title: tables.zip

description: :unav
DOI: 10.57745/wt3cxb
title: tlidar.zip

description: :unav
DOI: 10.57745/yukhda
title: ReadMe.txt

description: :unav
DOI: 10.57745/yhszaf
title: directories.txt

description: :unav
DOI: 10.57745/f4qw2w
title: file_list.txt

description: :unav
DOI: 10.17864/1947.000445
title: Atmospheric electricity data from the Bavarian Alps 1972-1983

description: Atmospheric electricity and other environmental measurements were made close to Garmisch-Partenkirchen, by Reinhold Reiter, at Mount Wank (1780 m, 47° 30' N, 11° 09' E). This archive contains recovered hourly measurements made at Wank from 1st August 1972 to 31st December 1983.
DOI: 10.6084/m9.figshare.21946595.v1
title: Supplementary Material for: Non-Invasive Zinc Protoporphyrin Screening Offers Opportunities for Secondary Prevention of Iron Deficiency in Blood Donors

description: <b><i>Background:</i></b> Frequent blood donors are at high risk of developing iron deficiency. Currently, there is no potent screening during blood donation to detect iron deficient erythropoiesis (IDE) before anemia develops and deferral from donation is inevitable. <b><i>Study Design and Methods:</i></b> In addition to capillary and venous hemoglobin, the iron status of 99 frequent blood donors was assessed by various venous blood parameters and zinc protoporphyrin IX (ZnPP). ZnPP was determined by high-performance liquid chromatography (HPLC) and a new prototype fiber-optic device was employed for non-invasive measurements of ZnPP through the blood collection tubing (NI-tubing) and on lip tissue (NI-lip). We aimed to evaluate the feasibility and diagnostic value of the NI-tubing measurement for early detection of severe iron deficiency in blood donors. <b><i>Results:</i></b> NI-tubing and HPLC reference measurements of ZnPP showed narrow limits of agreement of 12.2 μmol ZnPP/mol heme and very high correlation (Spearman’s Rho = 0.938). Using a cutoff of 65 μmol ZnPP/mol heme, NI-tubing measurements (<i>n</i> = 93) identified 100% of donors with iron deficiency anemia (IDA) and an additional 38% of donors with IDE. Accordingly, NI-tubing measurements would allow detection and selective protection of particularly vulnerable donors. <b><i>Conclusion:</i></b> NI-tubing measurements are an accurate and simple method to implement ZnPP determination into the routine blood donation process. ZnPP was able to identify the majority of subjects with IDE and IDA and might therefore be a valuable tool to provide qualified information to donors about dietary measures and adjustments of the donation interval and thereby help to prevent IDA and hemoglobin deferral in the future.
DOI: 10.5281/zenodo.7564621
title: Dataset related to article "Loco-Regional Treatment of the Primary Tumor in De Novo Metastatic Breast Cancer Patients Undergoing Front-Line Chemotherapy "

description: This record contains raw data related to article “Loco-Regional Treatment of the Primary Tumor in De Novo Metastatic Breast Cancer Patients Undergoing Front-Line Chemotherapy" <strong>Background: </strong> Loco-regional therapy (LRT) in de novo metastatic breast cancer (MBC) has been investigated in several clinical trials, with heterogeneous and conflicting results. <strong>Methods: </strong> We conducted a retrospective study of de novo MBC patients treated with front-line chemotherapy (FLC) followed by LRT of the primary tumor. Our aims were to evaluate the characteristics, treatment, and oncological outcomes in terms of progression-free survival (PFS), distant progression-free survival (DPFS), and overall survival (OS) of de novo MBC. We also investigated possible subgroups of patients with better outcomes according to menopausal status, biological sub-type, location, number of metastases, and radiologic complete response after FLC. <strong>Results: </strong> We included 61 patients in the study. After a median follow-up of 55 months, disease progression occurred in 60.7% of patients and 49.2% died. There were no significant differences in PFS, DPFS, and OS between different subgroups of de novo MBC patients. A trend toward better PFS and DPFS was observed in triple-positive tumors, without a statistically significant difference in OS. <strong>Conclusions: </strong> No specific subgroup of de novo MBC patients showed a statistically significant survival advantage after FLC followed by LRT of the primary tumor.
DOI: 10.5281/zenodo.7564620
title: Dataset related to article "Loco-Regional Treatment of the Primary Tumor in De Novo Metastatic Breast Cancer Patients Undergoing Front-Line Chemotherapy "

description: This record contains raw data related to article “Loco-Regional Treatment of the Primary Tumor in De Novo Metastatic Breast Cancer Patients Undergoing Front-Line Chemotherapy" <strong>Background: </strong> Loco-regional therapy (LRT) in de novo metastatic breast cancer (MBC) has been investigated in several clinical trials, with heterogeneous and conflicting results. <strong>Methods: </strong> We conducted a retrospective study of de novo MBC patients treated with front-line chemotherapy (FLC) followed by LRT of the primary tumor. Our aims were to evaluate the characteristics, treatment, and oncological outcomes in terms of progression-free survival (PFS), distant progression-free survival (DPFS), and overall survival (OS) of de novo MBC. We also investigated possible subgroups of patients with better outcomes according to menopausal status, biological sub-type, location, number of metastases, and radiologic complete response after FLC. <strong>Results: </strong> We included 61 patients in the study. After a median follow-up of 55 months, disease progression occurred in 60.7% of patients and 49.2% died. There were no significant differences in PFS, DPFS, and OS between different subgroups of de novo MBC patients. A trend toward better PFS and DPFS was observed in triple-positive tumors, without a statistically significant difference in OS. <strong>Conclusions: </strong> No specific subgroup of de novo MBC patients showed a statistically significant survival advantage after FLC followed by LRT of the primary tumor.
DOI: 10.5281/zenodo.7563512
title: CheckM2 Training Database

description: Synthetic genomes comprising the basis of CheckM2 training dataset, compressed into sparse matrices. With each update of CheckM2's models, updated training databases will be added.
DOI: 10.5281/zenodo.7563511
title: CheckM2 Training Database

description: Synthetic genomes comprising the basis of CheckM2 training dataset, compressed into sparse matrices. With each update of CheckM2's models, updated training databases will be added.
DOI: 10.5258/soton/wp00756
title: Kenya 100m Building class, version 1.0

description: Gridded maps of residential/non-residential building classifications and associated building patterns for Kenya (KEN), version 1.0
DOI: 10.6084/m9.figshare.21944927.v4
title: blimp_example_data

description: Image data and metadata used for example notebooks in the blimp package. From the parent directory, compress a _data folder using gzip: tar -czvf _data.gztar _data
DOI: 10.6084/m9.figshare.21946568
title: Literature search: Microfluidic characterization of enzymes

description: The dataset contains the records of scientific research articles which were found during the literature search focused on microfluidic characterization of enzymes. The description of the dataset is as follows: <br> For each study, we have collected information about the detection technique applied, enzyme characteristics, and studied enzymes, including their enzyme commission (EC) numbers, type of microfluidic device and the number of enzyme variants characterized. Furthermore, we have determined the development level of microfluidic technologies based on the searches both in the articles themselves and in the citing literature. Based on this search, we have classified the articles into three categories: (i) proof-of-concept (POC) studies, which only developed and demonstrated the microfluidic system, (ii) systematic applications, i.e., studies that employed the developed technology in at least one other study for similar characterization, and (iii) studies employing commercially available microfluidic technologies. Finally, we have acquired the number of citations and the average number of citations per year from the Web of Science database (results as of 18th January, 2023), while we don’t include citations and publications from 2023.
DOI: 10.5281/zenodo.7549841
title: Long-term secondary cardiovascular prevention programme in patients subjected to coronary artery bypass surgery

description: <strong>Aims: </strong>Patients with coronary heart disease (CHD) are at very high risk of recurrent events. A strategy to reduce excess risk might be to deliver structured secondary prevention programmes, but their efficacy has been mostly evaluated in the short term and in experimental settings. This is a retrospective case–control study aimed at assessing, in the real world, the efficacy of a secondary prevention programme in reducing long-term coronary event recurrences after coronary artery bypass surgery (CABG). <strong>Methods and results:</strong> Programme participants (henceforth ‘cases’) were men and women aged &lt;75 years subjected to CABG between 2002 and 2014, living within 100 km of the hospital. Key programme actions included optimization of treatments according to the most updated European preventive guidelines, surveillance of therapy adherence, and customized lifestyle counselling. Controls were analogous patients not involved in the programme because living farther than 100 km away, matched 1:1 with cases for gender, age at CABG, and year of CABG. Both groups (n = 1248) underwent usual periodic cardiology follow-up at our centre. Data on symptomatic or silent CHD recurrences were obtained from the hospital electronic health records. Cox analysis (adjusted for baseline differences between groups) shows that programme participation was associated with a significantly lower incidence throughout 5 years post-CABG of symptomatic [hazard ratio (95% confidence interval): 0.59 (0.38–0.94)] and silent [0.53 (0.31–0.89)] coronary recurrences. <strong>Conclusion:</strong> In a real-world setting, taking part in a structured longstanding secondary prevention programme, in addition to usual cardiology care, meaningfully lowers the risk of coronary recurrences.
description: This work was funded by the Italian Ministry of Health, Ricerca Corrente, grant ID 2755803, to Centro Cardiologico Monzino, IRCCS.
DOI: 10.5281/zenodo.7549840
title: Long-term secondary cardiovascular prevention programme in patients subjected to coronary artery bypass surgery

description: <strong>Aims: </strong>Patients with coronary heart disease (CHD) are at very high risk of recurrent events. A strategy to reduce excess risk might be to deliver structured secondary prevention programmes, but their efficacy has been mostly evaluated in the short term and in experimental settings. This is a retrospective case–control study aimed at assessing, in the real world, the efficacy of a secondary prevention programme in reducing long-term coronary event recurrences after coronary artery bypass surgery (CABG). <strong>Methods and results:</strong> Programme participants (henceforth ‘cases’) were men and women aged &lt;75 years subjected to CABG between 2002 and 2014, living within 100 km of the hospital. Key programme actions included optimization of treatments according to the most updated European preventive guidelines, surveillance of therapy adherence, and customized lifestyle counselling. Controls were analogous patients not involved in the programme because living farther than 100 km away, matched 1:1 with cases for gender, age at CABG, and year of CABG. Both groups (n = 1248) underwent usual periodic cardiology follow-up at our centre. Data on symptomatic or silent CHD recurrences were obtained from the hospital electronic health records. Cox analysis (adjusted for baseline differences between groups) shows that programme participation was associated with a significantly lower incidence throughout 5 years post-CABG of symptomatic [hazard ratio (95% confidence interval): 0.59 (0.38–0.94)] and silent [0.53 (0.31–0.89)] coronary recurrences. <strong>Conclusion:</strong> In a real-world setting, taking part in a structured longstanding secondary prevention programme, in addition to usual cardiology care, meaningfully lowers the risk of coronary recurrences.
description: This work was funded by the Italian Ministry of Health, Ricerca Corrente, grant ID 2755803, to Centro Cardiologico Monzino, IRCCS.
DOI: 10.5258/soton/wp00757
title: Mozambique 100m Building class, version 1.0

description: Gridded maps of residential/non-residential building classifications and associated building patterns for Mozambique (MOZ), version 1.0
DOI: 10.5525/gla.researchdata.1307
title: INCISE mutational data – Longitudinal polyp study (Nov 2021)

description: The INCISE project identified 93 future polyp samples from archived FFPE tissue for DNA extraction. The extracted DNA was then passed to the Glasgow Precision Oncology Laboratory (GPOL) for genomic sequencing using GPOL’s bespoke Cancer Plus panel. The output from the sequencing is FASTQ files (~223GB) which will be deposited for at least 10 years in Enlighten.