cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.21353361.v1
title: Genetics in Medicine and Nursing: perceptions of health professionals involved in teaching and learning process

description: Abstract: Introduction: The evolution of genetics has led to medical and nursing entities recommending specific skills to their health professionals. Professors and preceptors in the area must therefore introduce and discuss genetics accordingly to ensure proper training for students. Objective: This study aimed to explore how professors and preceptors of Medicine and Nursing courses at a Brazilian public university perceive the subject matter of genetics in the teaching and learning process of undergraduate studies. Method: This is a descriptive, exploratory, and cross-sectional study that was conducted with a convenience sample, and data was collected through a self-administered electronic questionnaire. In total, 317 professionals were invited and 40 (12.6%) participated. Descriptive data statistics were developed and classified into five categories: 1. description, academic training, and professional information; 2. genetics in the teaching and learning process; 3. continuing education in medical/clinical genetics; 4. genetics in clinical practice; and 5. genetic testing. Result: Twenty-eight (70%) physicians, seven (17.5%) nurses, and five (12.5%) professionals from other health areas participated in the sample, 87.5% of whom have a postgraduate qualification. As regards the teaching and learning process, 31 (77.5%) participants reported that their work was indirectly related to genetics, although 29 (72.5%) had never carried out a continuing education activity in the area. In clinical practice, two (5.0%) participants investigated family history up to three generations back, ten (25%) participants reported advising pregnant women about teratogens during pregnancy and lactation, and 17 (42.5%) reported occasionally referring patients to a genetics specialist. In general, participants were able to identify the main clinical characteristics that lead to suspected genetic diseases, although some situations were underestimated, such as the importance of genetic counseling in cases of consanguinity and advanced maternal or paternal age. Regarding genetic tests, only five (12%) participants reported feeling confident enough to request, interpret, and communicate results. Conclusion: Professors and preceptors in health areas are expected to encourage students to connect theory and practice, incorporating skills and competencies related to genetics into the comprehensive care of individuals. Based on these results, opportunities may be identified to improve the teaching of genetics in this and other higher education institutions.
DOI: 10.6084/m9.figshare.21353367
title: Translation and validation of the drooling impact scale questionnaire into Brazilian Portuguese

description: Abstract Introduction Inadequate drooling can cause serious clinical, functional and social problems. Validated questionnaires to evaluate drooling impact on quality of life are lacking in Brazilian Portuguese. Objectives To translate and validate the drooling impact scale to Brazilian Portuguese. Methods The drooling impact scale was translated to Brazilian Portuguese and back- translated to English to assess potential conceptual differences. Brazilian Portuguese version of drooling impact scale was applied to a 40 patients’ sample of sialorrhea presenting pediatric patients (up to 20 years of age). Chronbach’s alpha, exploratory factorial analysis and confirmatory factorial analysis were then proceeded with data collected. Results The mean drooling impact scale value for the whole population was 51.77 (SD = 16.13). The internal consistency obtained with Cronbach’s alpha indicated a value of 0.72 for the entire sample. The Bartlett’s test of sphericity was significant (p&lt; 0.0001), confirming correlation among variables tested. Kaiser-Meyer-Olkin measure of sampling adequacy revealed a value of 0.72, indicating that the correlation matrix was reasonably suitable for factor analysis. Regarding exploratory factorial analysis, parallel analysis suggested a two-factor solution that was used for confirmatory factorial analysis. The first factor was responsible for 33.78% of the variance with an Eigenvalue of 3.38. The second factor explained 16.1% of the variance with an Eigenvalue of 1.61. At confirmatory factorial analysis, the two-factor model showed consistently better adjustments parameters than the one-factor model. Conclusion The drooling impact scale has been successfully translated to Brazilian Portuguese language, showing adequate internal validity. Validation of this instrument allows physicians and other personnel involved in the care of these patients to perform a better management of patients experiencing drooling. With this tool, we are now able to guide routines and provide guidelines both before and after the different kinds of treatments in order to improve the general well-being of the patient and his family.
DOI: 10.6084/m9.figshare.21353367.v1
title: Translation and validation of the drooling impact scale questionnaire into Brazilian Portuguese

description: Abstract Introduction Inadequate drooling can cause serious clinical, functional and social problems. Validated questionnaires to evaluate drooling impact on quality of life are lacking in Brazilian Portuguese. Objectives To translate and validate the drooling impact scale to Brazilian Portuguese. Methods The drooling impact scale was translated to Brazilian Portuguese and back- translated to English to assess potential conceptual differences. Brazilian Portuguese version of drooling impact scale was applied to a 40 patients’ sample of sialorrhea presenting pediatric patients (up to 20 years of age). Chronbach’s alpha, exploratory factorial analysis and confirmatory factorial analysis were then proceeded with data collected. Results The mean drooling impact scale value for the whole population was 51.77 (SD = 16.13). The internal consistency obtained with Cronbach’s alpha indicated a value of 0.72 for the entire sample. The Bartlett’s test of sphericity was significant (p&lt; 0.0001), confirming correlation among variables tested. Kaiser-Meyer-Olkin measure of sampling adequacy revealed a value of 0.72, indicating that the correlation matrix was reasonably suitable for factor analysis. Regarding exploratory factorial analysis, parallel analysis suggested a two-factor solution that was used for confirmatory factorial analysis. The first factor was responsible for 33.78% of the variance with an Eigenvalue of 3.38. The second factor explained 16.1% of the variance with an Eigenvalue of 1.61. At confirmatory factorial analysis, the two-factor model showed consistently better adjustments parameters than the one-factor model. Conclusion The drooling impact scale has been successfully translated to Brazilian Portuguese language, showing adequate internal validity. Validation of this instrument allows physicians and other personnel involved in the care of these patients to perform a better management of patients experiencing drooling. With this tool, we are now able to guide routines and provide guidelines both before and after the different kinds of treatments in order to improve the general well-being of the patient and his family.
DOI: 10.6084/m9.figshare.21353369
title: Comparative study of reliability of inflammatory markers over 18-FDG−PET CT scan in monitoring skull base osteomyelitis

description: Abstract Introduction The end point of treatment in skull base osteomyelitis is a matter of debate. A treatment based on symptoms alone is fraught with recurrence. There is a need to restrict imaging though more informative. The inflammatory markers like C-reactive protein and erythrocyte sedimentation rate used commonly need a detailed evaluation to optimize its utility. Objectives To compare the diagnostic accuracy of inflammatory markers with a hybrid PET scan in monitoring skull base osteomyelitis. The secondary objective was to obtain a cut-off value of these markers to decide upon antibiotic termination. Methods A prospective cohort study was conducted in a tertiary care center with fifty-one patients with skull base osteomyelitis meeting eligibility criteria. Patients diagnosed with skull base osteomyelitis were serially monitored with weekly markers and PET scan after the initiation of treatment. A hybrid scan was taken at 6-8 weeks of treatment and repeated if required. The follow-up period varied from 6 weeks to 15 months. The outcome measures studied were the values of markers and the metabolic activity of PET scan when the patient became asymptomatic and when disease-free. Results C-reactive protein and erythrocyte sedimentation rate had a statistically significant correlation to disease activity in PET tomography scan as a prognostic marker. Both showed good clinical correlation. A cut off value of ≤ 3.6 mg/L for C-reactive protein and ≤ 35 mm/hour for erythrocyte sedimentation rate were taken as normalized values. Conclusion A consistent normalized value of C-reactive protein and erythrocyte sedimentation rate for 8-12 weeks in an asymptomatic patient may be an indicator of disease control, though not cure. So, relying solely on markers alone for antibiotic termination may cause relapse. It may be used cautiously in a peripheral setting without access to more specific hybrid scans. In a tertiary care, follow-up scans may be done based on the titres, thereby limiting the radiation exposure.
DOI: 10.6084/m9.figshare.21353369.v1
title: Comparative study of reliability of inflammatory markers over 18-FDG−PET CT scan in monitoring skull base osteomyelitis

description: Abstract Introduction The end point of treatment in skull base osteomyelitis is a matter of debate. A treatment based on symptoms alone is fraught with recurrence. There is a need to restrict imaging though more informative. The inflammatory markers like C-reactive protein and erythrocyte sedimentation rate used commonly need a detailed evaluation to optimize its utility. Objectives To compare the diagnostic accuracy of inflammatory markers with a hybrid PET scan in monitoring skull base osteomyelitis. The secondary objective was to obtain a cut-off value of these markers to decide upon antibiotic termination. Methods A prospective cohort study was conducted in a tertiary care center with fifty-one patients with skull base osteomyelitis meeting eligibility criteria. Patients diagnosed with skull base osteomyelitis were serially monitored with weekly markers and PET scan after the initiation of treatment. A hybrid scan was taken at 6-8 weeks of treatment and repeated if required. The follow-up period varied from 6 weeks to 15 months. The outcome measures studied were the values of markers and the metabolic activity of PET scan when the patient became asymptomatic and when disease-free. Results C-reactive protein and erythrocyte sedimentation rate had a statistically significant correlation to disease activity in PET tomography scan as a prognostic marker. Both showed good clinical correlation. A cut off value of ≤ 3.6 mg/L for C-reactive protein and ≤ 35 mm/hour for erythrocyte sedimentation rate were taken as normalized values. Conclusion A consistent normalized value of C-reactive protein and erythrocyte sedimentation rate for 8-12 weeks in an asymptomatic patient may be an indicator of disease control, though not cure. So, relying solely on markers alone for antibiotic termination may cause relapse. It may be used cautiously in a peripheral setting without access to more specific hybrid scans. In a tertiary care, follow-up scans may be done based on the titres, thereby limiting the radiation exposure.
DOI: 10.57745/goomdl
title: data_bucknell1995.csv

description: Strongyle species collected in horses necropsied in the state of Victoria (Australia) as described in Bucknell et al. 1995.
DOI: 10.57745/wnwivf
title: ColonD.tab

description: Strongyle species collected in the dorsal colon of horses necropsied in Normandy (France) as described in Collobert-Laugier et al. 2002.
DOI: 10.57745/df2dlq
title: data_kuzmina2016.csv

description: Strongyle species counts and metadata collected from horses in Ukraine, as described in Kuzmina et al. 2016.
DOI: 10.57745/qusmj1
title: caecum.tab

description: Strongyle species collected in the caecum of horses necropsied in Normandy (France) as described in Collobert-Laugier et al. 2002.
DOI: 10.57745/20yz2a
title: Age_samplingCL.tab

description: Metadata associated with horse necropsied in Normandy (France) as described in Collobert-Laugier et al. 2002.
DOI: 10.57745/wkncpz
title: Poland2018.csv

description: Strongyle species counts and metadata collected from horses in Poland, as described in Sallé et al. 2018.
DOI: 10.57745/gltm5r
title: ColonV.tab

description: Strongyle species collected in the ventral colon of horses necropsied in Normandy (France) as described in Collobert-Laugier et al. 2002.
DOI: 10.6084/m9.figshare.21353370
title: Protective effect of kaempferol against cisplatin-induced acute ovarian damage in a mouse model

description: ABSTRACT The flavonoid kaempferol has attracted research attention as a potential adjuvant during chemotherapy. This study aimed to evaluate the protective effects of kaempferol against ovarian damage in cisplatin-treated mice. Two groups of mice received saline solution (intraperitoneal injection [i.p.]; control) or a single dose of cisplatin (5 mg/kg body weight, i.p.). Moreover, two other mice groups were pretreated with kaempferol (1 or 10 mg/kg body weight, i.p.) 30 min before of the cisplatin administration. Thereafter, their ovaries were harvested and subjected to histological (follicular morphology and activation) and fluorescence (reactive oxygen species [ROS] production, glutathione [GSH] concentration, and mitochondrial activity) analyses. Compared with cisplatin treatment alone, pretreatment with 1 mg/kg kaempferol maintained normal follicular morphology, reduced ROS production and mitochondrial damage, and enhanced GSH concentration. However, pretreatment with 10 mg/kg kaempferol did not prevent cisplatin-induced damage. The rate of primordial follicle activation was greater in mice pretreated with 1 mg/kg kaempferol than in the other treatment groups. In conclusion, pretreatment with 1 mg/kg kaempferol prevents cisplatin-induced ovarian damage and stimulates primordial follicle activation in mice.
DOI: 10.6084/m9.figshare.21353370.v1
title: Protective effect of kaempferol against cisplatin-induced acute ovarian damage in a mouse model

description: ABSTRACT The flavonoid kaempferol has attracted research attention as a potential adjuvant during chemotherapy. This study aimed to evaluate the protective effects of kaempferol against ovarian damage in cisplatin-treated mice. Two groups of mice received saline solution (intraperitoneal injection [i.p.]; control) or a single dose of cisplatin (5 mg/kg body weight, i.p.). Moreover, two other mice groups were pretreated with kaempferol (1 or 10 mg/kg body weight, i.p.) 30 min before of the cisplatin administration. Thereafter, their ovaries were harvested and subjected to histological (follicular morphology and activation) and fluorescence (reactive oxygen species [ROS] production, glutathione [GSH] concentration, and mitochondrial activity) analyses. Compared with cisplatin treatment alone, pretreatment with 1 mg/kg kaempferol maintained normal follicular morphology, reduced ROS production and mitochondrial damage, and enhanced GSH concentration. However, pretreatment with 10 mg/kg kaempferol did not prevent cisplatin-induced damage. The rate of primordial follicle activation was greater in mice pretreated with 1 mg/kg kaempferol than in the other treatment groups. In conclusion, pretreatment with 1 mg/kg kaempferol prevents cisplatin-induced ovarian damage and stimulates primordial follicle activation in mice.
DOI: 10.6084/m9.figshare.21353375
title: Bacterial pneumonia in horses associated with Escherichia coli infection: report of five cases

description: ABSTRACT Respiratory diseases have a major impact on sport horses and are often cited as the second most common reason for loss of training days and significant veterinary costs. Adult horses most commonly develop pneumonia when bacteria aspirated from the environment, nose, or oropharynx reach the lower airways and overwhelm the pulmonary defense mechanisms. This article report five cases of bacterial pneumonia in horses associated with infection by Eschericia coli. Five Quarter horses, three males and two females, with ages varying from 5 to 12 years, were examined for diagnosis of respiratory disease characterized by apathy, cough and lack of appetite. Auscultation of the thorax revealed increased harsh breath sounds dorsally, crackles, wheezes, and dullness of respiratory sounds ventrally. Manipulation of the trachea and larynx induced cough. Culture results were positive for Escherichia coli. The therapeutic protocol consisted of anti-inflammatory, antibiotic therapy, and supportive care. Flunixin meglumine was administered intravenously at 24-hour intervals over eight days. Ceftiofur sodium was prescribed intramuscularly, q.d., for 15 days. Horses were clinically monitored daily until complete remission of clinical signs. None of the animals relapsed, and all returned to routine athletic activities.
DOI: 10.6084/m9.figshare.21353375.v1
title: Bacterial pneumonia in horses associated with Escherichia coli infection: report of five cases

description: ABSTRACT Respiratory diseases have a major impact on sport horses and are often cited as the second most common reason for loss of training days and significant veterinary costs. Adult horses most commonly develop pneumonia when bacteria aspirated from the environment, nose, or oropharynx reach the lower airways and overwhelm the pulmonary defense mechanisms. This article report five cases of bacterial pneumonia in horses associated with infection by Eschericia coli. Five Quarter horses, three males and two females, with ages varying from 5 to 12 years, were examined for diagnosis of respiratory disease characterized by apathy, cough and lack of appetite. Auscultation of the thorax revealed increased harsh breath sounds dorsally, crackles, wheezes, and dullness of respiratory sounds ventrally. Manipulation of the trachea and larynx induced cough. Culture results were positive for Escherichia coli. The therapeutic protocol consisted of anti-inflammatory, antibiotic therapy, and supportive care. Flunixin meglumine was administered intravenously at 24-hour intervals over eight days. Ceftiofur sodium was prescribed intramuscularly, q.d., for 15 days. Horses were clinically monitored daily until complete remission of clinical signs. None of the animals relapsed, and all returned to routine athletic activities.
DOI: 10.6084/m9.figshare.21353379
title: Biomass production and salt extraction by species alone or associated in the revegetation strategy

description: ABSTRACT Anthropogenic actions have caused soil degradation and revegetation is a way to recover degraded soils. However, salt-affected soils require the use of suitable species to extract salts from the soil. This study investigated the growth of shrub and tree species in a soil degraded by salts, alone or associated with a phytoextraction salt species, evaluating plant biomass yield and extraction of elements by plants. A field experiment was assembled with eight treatments: 1) Atriplex nummularia Lindl., 2) Mimosa caesalpiniifolia Benth, 3) Leucaena leucocephala (Lam.) Wit, 4) Azadirachta indica A. Juss, 5) A. nummularia + M. caesalpiniifolia, 6) A. nummularia + L. leucocephala and 7) A. nummularia + A. indica; in randomized blocks with four replications. After 30 months of cultivation, plants were collected to measure biomass and concentrations of Na, K, Ca, Mg, Cl, P, and N. A. indica plants had the highest total biomass (10.75 kg plant-1), about 15 times more than M. caesalpiniifolia, both in associated cultivation with A. nummularia. A. nummularia plants extracted more Na and Cl in the dry matter, maximum of 124.70 and 166.79 g plant-1, respectively. The highest production of plant biomass (23.55 t ha-1) and total extraction of elements (1438.51 kg ha-1) were obtained by associated cultivation of A. nummularia and A. indica. Associated cultivation did not decrease the phytoextractor potential of Na and Cl by A. nummularia plants and it can be used to regenerate degraded areas.
DOI: 10.6084/m9.figshare.21353379.v1
title: Biomass production and salt extraction by species alone or associated in the revegetation strategy

description: ABSTRACT Anthropogenic actions have caused soil degradation and revegetation is a way to recover degraded soils. However, salt-affected soils require the use of suitable species to extract salts from the soil. This study investigated the growth of shrub and tree species in a soil degraded by salts, alone or associated with a phytoextraction salt species, evaluating plant biomass yield and extraction of elements by plants. A field experiment was assembled with eight treatments: 1) Atriplex nummularia Lindl., 2) Mimosa caesalpiniifolia Benth, 3) Leucaena leucocephala (Lam.) Wit, 4) Azadirachta indica A. Juss, 5) A. nummularia + M. caesalpiniifolia, 6) A. nummularia + L. leucocephala and 7) A. nummularia + A. indica; in randomized blocks with four replications. After 30 months of cultivation, plants were collected to measure biomass and concentrations of Na, K, Ca, Mg, Cl, P, and N. A. indica plants had the highest total biomass (10.75 kg plant-1), about 15 times more than M. caesalpiniifolia, both in associated cultivation with A. nummularia. A. nummularia plants extracted more Na and Cl in the dry matter, maximum of 124.70 and 166.79 g plant-1, respectively. The highest production of plant biomass (23.55 t ha-1) and total extraction of elements (1438.51 kg ha-1) were obtained by associated cultivation of A. nummularia and A. indica. Associated cultivation did not decrease the phytoextractor potential of Na and Cl by A. nummularia plants and it can be used to regenerate degraded areas.
DOI: 10.6084/m9.figshare.21353385
title: Sources of medicines for hypertension and diabetes in Brazil: results from the National Health Survey

description: This study aims to analyze the sources people over 18 years of age use to obtain medication for the treatment of hypertension and diabetes, according to sociodemographic characteristics from 2013 to 2019. Data from the Brazilian National Health Survey were analyzed. Most individuals with diagnosis and prescription to pharmacological treatment reported obtaining medicines exclusively from one type of source. The percentage of people who acquired hypertension medicine exclusively from public pharmacies decreased, from 24.5% in 2013 to 16.2% in 2019; while there was an increase in those obtaining from the Popular Pharmacy program, from 23.5% to 31.4%; as well as for out-of-pocket payment, which rose from 30.9% to 35.5% The percentage of people who acquired diabetes medication exclusively from public pharmacies increased from 7.4% to 18.6% and with out-of-pocket payment increased from 21.6% to 26.8%, while the percentage of those who acquired from the Popular Pharmacy program decreased from 47.2% to 36.4%. The percentage of those who acquired medication from various sources decreased for both hypertension and diabetes. For men, white, and those with higher education, the source of medication acquisition, for both conditions, was mostly by out-of-pocket payment. The high number of medicine acquisition from public sources represents an advance in Brazil’s response to the treatment of these conditions, but reducing regional differences still represents a challenge to be overcome by the healthcare system.