cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.5517/cc6npm4
title: CCDC 198636: Experimental Crystal Structure Determination

description: Related Article: T.Kaehler, F.Olbrich|2002|CSD Communication|||
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.6084/m9.figshare.24973263
title: Supplementary Material for: A Phase 3 Study of Pembrolizumab Versus Placebo for Previously Treated Patients From Asia With Hepatocellular Carcinoma: Health-Related Quality of Life Analysis From KEYNOTE-394

description: Introduction
KEYNOTE-394 showed pembrolizumab significantly improved overall survival, progression-free survival, and objective response rate with manageable safety versus placebo for patients from Asia with previously treated advanced hepatocellular carcinoma. We present results on health-related quality of life (HRQoL).

Methods
HRQoL was evaluated using the EORTC Quality of Life Questionnaire-Core 30 (EORTC QLQ-C30) and EuroQol-5D-3L (EQ-5D-3L) questionnaires. Key HRQoL endpoints were least squares mean (LSM) score changes from baseline to week 12 and time to deterioration (TTD) for EORTC QLQ-C30 global health status (GHS)/QoL. p values were one-sided and nominal without adjustment for multiplicity.

Results
The HRQoL population included patients randomly assigned to pembrolizumab (n = 298) and placebo (n = 152). From baseline to week 12, a greater decline in EORTC QLQ-C30 GHS/QoL score was observed with placebo (LSM, −8.4; 95% CI: −11.7 to −5.1) versus pembrolizumab (−4.0; 95% CI: −6.4 to −1.6; difference vs placebo: 4.4; 95% CI: 0.5–8.4; nominal p = 0.0142). Similarly, a greater decline in EQ-5D-3L visual analog scale score was observed with placebo (−6.9; 95% CI: −9.4 to −4.5) versus pembrolizumab (−2.7; 95% CI: −4.5 to −1.0; difference vs placebo: 4.2; 95% CI: 1.2–7.2; nominal p = 0.0030). TTD in EORTC QLQ-C30 GHS/QoL score was similar between arms (hazard ratio, 0.85; 95% CI: 0.58–1.25; nominal p = 0.1993).

Conclusion
Patients receiving placebo showed greater decline in HRQoL than those receiving pembrolizumab. Combined with efficacy and safety data from KEYNOTE-394 and the global KEYNOTE-240 and KEYNOTE-224 trials, our data support the clinically meaningful benefit and manageable tolerability of pembrolizumab as second-line therapy for patients with advanced hepatocellular carcinoma.
DOI: 10.6084/m9.figshare.25634034
title: Supplementary Material for: Hand dystonia after focused ultrasound thalamotomy in essential tremor

description: Introduction
Magnetic resonance guided focused ultrasound (MRgFUS) thalamotomy is an effective treatment for drug-resistant tremor. The most frequent side effects are ataxia, gait disturbance, paresthesias, dysgeusia, and hemiparesis. Here, we report the first case of thalamic hand dystonia rapidly occurring after MRgFUS thalamotomy of the ventral intermediate nucleus (V.im). 
Case presentation
MRgFUS thalamotomy was performed in a 60-year-old left-handed patient for his disabling medically refractory essential tremor. The intervention resulted in a marked reduction of his action tremor. However, the patient developed an unvoluntary abnormal posture in his left hand a few days after the procedure with difficulty holding a cigarette between his fingers. Brain MRI revealed the expected MRgFUS lesion within the right V.im as well as an extension of the lesion anteriorly to the V.im in the ventro-oralis nucleus. Tractography showed that the lesion disrupted the dentato-rubro-thalamic tract as expected with a lesion suppressing tremor. However, the lesion also was interrupted fibers connecting to the superior frontal and pre-central cortices (primary motor cortex, premotor cortex, and supplementary area). We hypothesized that the interventional MRgFUS thalamotomy was slightly off target, which induced a dysfunction within the cortico-striato-thalamo-cortical network and the cerebello-thalamo-cortical pathway reaching a sufficient threshold of basal ganglia/cerebellum circuitry interference to induce dystonia. 
Conclusion
This rare side effect emphasizes the risk of imbalance within the dystonia network (i.e. basal ganglia-cerebello-thalamo-cortical circuit) secondary to V.im thalamotomy.
DOI: 10.6084/m9.figshare.25943869.v1
title: PRISMA_2020_checklist_AYS

description: PRISMA_2020_checklist_AYS
DOI: 10.6084/m9.figshare.26325805
title: Supplementary Material for: White Matter Hyperintensities Are Associated with Slower Gait Speed in Older Adults Without Dementia

description: Background: Slow gait speed is associated with poor health outcomes in aging, but the relationship between cerebral small vessel disease (CSVD) pathologies and gait speed in aging is not well understood. We investigated the relationships between cerebral small vessel disease (CSVD) imaging markers and gait speed during simple (normal pace walking (NPW)) and complex (walking-while talking (WWT)) as both measures are associated with shared health outcomes such as falls, frailty, disability, mortality, and dementia. 
Methods: A total of 113 Ashkenazi Jewish adults over 65 (M age=78.6±6.3 years, 45.8% women) and without dementia were examined. Established rating systems were used to quantify white matter hyperintensities (WMH) and lacunes of presumed vascular origin from Fluid Attenuated Inversion Recovery (FLAIR) images. Linear regression models adjusted for age, sex, global health, and total intracranial volume were used to examine associations between CSVD markers and gait speed during NPW and WWT. Student t-tests were used to contrast gait speed in those with “confluent-diffuse” WMH and those with “mild or no” WMH. 
Results: The number of WMH in the basal ganglia (β=-3.274 cm/s p=.047) and temporal lobes (β=-3.113 cm/s p=.048) were associated with slower NPW speed in adjusted models. Participants with higher CSVD burden (confluent-diffuse pattern) in the frontal lobe (94.65 cm/s vs. 105.21 cm/s, p=.018) and globally (98.98 cm/s vs. 107.24 cm/s, p=.028) also had lower NPW speed. WMH were not associated with WWT speeds. Lacunes were not associated with NPW or WWT speed. 
Conclusion: Adjusted models found higher CSVD burden as measured by the presence of WMH in the basal ganglia and temporal lobes were associated with slower normal pace gait speed in older adults, but not with complex walking speeds. Participants with confluent-diffuse WMHs in the frontal lobes were found to have slower average normal gait speed. Further studies are needed to establish the temporality of WMH and gait speed decline as well as mechanistic links between the two.
DOI: 10.6084/m9.figshare.5895955.v1
title: <i>Preussia</i> sp. BSL-10 producing nitric oxide, gibberellins, and indole acetic acid and improving rice plant growth

description: <i>Preussia</i> sp. have been least known to improve plant growth and produce phytohormones. The current study investigated the production of nitric oxide (NO), indole-3-acetic acid (IAA), and gibberellins (GA<sub>4</sub>, GA<sub>7</sub>, GA<sub>15</sub>, and GA<sub>53</sub>) by a novel endophytic-fungal strain <i>Preussia</i> sp<i>.</i> BSL-10 using advanced chromatographic and spectroscopic techniques. Production of these phytohormones were validated by RT–PCR analysis, which indicated the expression of genes encoding <i>tryptophan synthase</i> (<i>TRP</i>), <i>indole-3-acetamide hydrolase (IAAH), tryptophan-2-monooxygenase (IAAM), aldehyde dehydrogenase (ALD), GA<sub>4</sub> desaturase (DES), geranylgeranyl-diphosphate synthase (GGS2), ent-desaturase oxidase (P450-4), GA<sub>14</sub> synthase (P450-1) and nitrite reductase (NIRK/NIRS), cytochrome P450 (P450nor), nitrate reductase (NR), NOS-like (NOL),</i> and <i>nitric oxide reductase (QNOR/CNOR).</i> In plant growth-promoting effects, the inoculation of <i>Preussia</i> sp. BSL-10 significantly increased the growth of dwarf mutant <i>Waito-C</i> and wild-type rice cultivars. In conclusion, utilizing new endophytic with the ability to produce NO, IAA, and gibberellins can be used to promote growth and yield of marginalized crops.
DOI: 10.14469/hpc/12928
title: Endo_TS1, B2PLYPD3/Def2-QZVPP, superfine, SCRF=DCM, G = -823.137952, ΔG = 5.5, GN 0.000007396, ΔΔG = 0.45 kcal/mol.

description: G = -823.137952 =&gt; @195K -823.121956 and 13-d -823.124642 d-14 -823.125245 DG exo-endo 0.35 kcal/mol

Endo -823.132891 13-d @250 Exo G = -823.133522 14-d @250 endo-exo = 0.396

Ratio exo/endo = 2.47 @ 195K

Ration exo/endo = 2.22 @ 250K
DOI: 10.14469/hpc/13261
title: Endo_TS1_G16_PCM_dichloromethane_def2qzvpp_v_01, + dispersion correction, G = -823.651168

description: Gaussian 16 (C01) calculation
DOI: 10.14469/hpc/13276
title: Swern oxidation, TS1-endo, B3LYP+GD3+BJ/Def2-QZVPP, SCRF= IEFPCM,chloroform, =&gt; 1HCCl3 explicit solvents, G = -2243.107354

description: Gaussian 16 (C01) calculation
DOI: 10.14469/hpc/13320
title: Endo_TS1_G16_PCM_def2tzvpp_v_02_bis(dimethylamine) + Dispersion G = -1091.561437, ΔG = 6.28

description: Gaussian 16 (C01) calculation
DOI: 10.14469/hpc/13326
title: Endo_TS1_G16_PCM_DCM_def2qzvpp_v_02_bis(trifluoromethyl) + dispersion G = -1498.069257, ΔG = 19.77

description: Gaussian 16 (C01) calculation
DOI: 10.5281/zenodo.12772670
title: Evaluation of the Impact of the Educational Revolution in Peru and the Gender Wage Gap, 2017-2021

description: Background: Women's educational attainment and their generation of value through education has increased the prospects for achieving economic equality between men and women. However, women continue to earn lower wages than men, reflecting growing inequality in several countries. Therefore, the objective of the study is to estimate the impact of education on the gender wage gap in Peru over the period 2017-2021.

Methods: Quantitative, explanatory study aimed at identifying the impact of education on the gender wage gap in Peru during the period 2017-2021. The research design is non-experimental and uses a time series that analyses the influence of the latent variable of education on the gender wage gap. This is a continuous variable to estimate the Tobit model.

Results: The results show that the gender gap in Peru exhibited a decreasing trend between men and women during the period 2017-2020, with an average reduction of 10% until 2020 due to the health crisis. The highest average salary was achieved by men in 2019, reaching S/2289.97 soles, while women reached an average salary of S/1368.85 soles. In the post-pandemic scenario for 2021, the gender gap increased by 3%, with men earning an average salary of S/1999.63 soles and women earning an average salary of S/1281.16 soles. The analysis from 2017-2021 shows that years of education had a positive impact on the gender wage gap in Peru based on the Tobit model estimation.

Conclusions: During the analysis period of 2017-2021, years of education had a positive impact on the gender wage gap in Peru, with the greatest impact occurring during the health crisis. The probability of women's incomes improving with an increase in years of education was 2.35%, while for men, the highest impact was in 2018, with a probability of income improvement of 2.16% in terms of marginal effect.
DOI: 10.5281/zenodo.3843441
title: Code and data for rosid_NCOMMS-19-37964

description: Sun et al. (2020) Recent accelerated diversification in rosids occurred outside the tropics.
DOI: 10.5281/zenodo.5016186
title: Glover et al 2021 Vape Expo Data

description: Data underlying analysis presented in paper 'Vaping liquid flavour preferences, oral nicotine pouch and cannabis use among participants in the 2019 Oceania Vape Expo' submitted to F1000 Research.
description: This study was funded with a grant from the Foundation for a Smoke-Free World, a US nonprofit 501(c)(3) private foundation with a mission to end smoking in this generation. The Foundation accepts charitable gifts from PMI Global Services Inc. (PMI); under the Foundation's Bylaws and Pledge Agreement with PMI, the Foundation is independent from PMI and the tobacco industry. The contents, selection, and presentation of facts, as well as any opinions expressed herein are the sole responsibility of the authors and under no circumstances shall be regarded as reflecting the positions of the Foundation for a Smoke-Free World, Inc. The Foundation had no involvement in the conception, design, analysis or writing of the study results, nor did they have any input into the decision to publish. The contents, selection, and presentation of facts, as well as any opinions expressed herein, are the sole responsibility of the authors.
DOI: 10.5281/zenodo.6619260
title: CryoGridLite: Model output of pan-Arctic simulations at 1° resolution from 1700 to 2020

description: <strong>CryoGridLite</strong> is a lightweight version of the more complex and process-rich <strong>CryoGrid Community model</strong> (Westermann et al. 2022). This archive contains the following output datasets which were produced by the model. <code>./SETUP.zip</code> The parameters varied in the ensemble simulations.<br> <code>./RESULTS.zip</code> The output variables. An overview of the output variables is provided below and in the README.md file of the archived code. The model code can be found here: 10.5281/zenodo.6619537 Input data required for pan-Arctic simulations can be found here: 10.5281/zenodo.6619212 Variable Coordinates Description <strong>H_lat_sum</strong> <em>(tile, time, longitude, latitude)</em> Total latent heat content in the entire ground column (550m) [J/m²] <strong>H_sen_sum</strong> <em>(tile, time, longitude, latitude)</em> Total sensible heat content in the entire ground column (550m) [J/m²] <strong>H_tot_sum</strong> <em>(tile, time, longitude, latitude)</em> Total heat content in the entire ground column (550m) [J/m²] <strong>H_lat_50m</strong> <em>(tile, time, longitude, latitude)</em> Total latent heat content in the uppermost 50m of the ground column [J/m²] <strong>H_sen_50m</strong> <em>(tile, time, longitude, latitude)</em> Total sensible heat content in the uppermost 50m of the ground column [J/m²] <strong>H_tot_50m</strong> <em>(tile, time, longitude, latitude)</em> Total heat content in the uppermost 50m of the ground column [J/m²] <strong>ThawedGround_10m</strong> <em>(tile, time, longitude, latitude)</em> Maximum vertically integrated depth of thawed ground (T&gt;0°C) in the uppermost 10m of the ground column [m] <strong>T_av_all</strong> <em>(tile, time, longitude, latitude, depth)</em> Mean annual ground temperature [°C] <strong>T_min_all</strong> <em>(tile, time, longitude, latitude, depth)</em> Minimum annual ground temperature [°C] <strong>T_max_all</strong> <em>(tile, time, longitude, latitude, depth)</em> Maximum annual ground temperature [°C] <strong>LandArea</strong> <em>(latitude, longitude)</em> Total area covered by land within the model grid cell [km²]
DOI: 10.5281/zenodo.8076483
title: Raman spectral data for mature mouse placenta scans

description: Pre-processed and normalized Raman spectral data for three mouse placental tissue scans, and constructed image data at three different wavenumbers.
DOI: 10.5281/zenodo.8089297
title: Simulated_bending_spectras_and_NN_network

description: This folder is used as a supplementary material for article "Fiber shape sensing using Long Period Fiber Grating and Machine Learning Numerical analysis". It comprises first matlab generated data in the form of fiber random bending profiles and their associated LPG spectral transmission, as calculated with coupled-mode-theory. Then, the data has been used to train a keras NN model, that is also given in the folder.
DOI: 10.5523/bris.ypfrg4sz8jwi2ehjqjubbq526
title: 3D OCT Images of Murine Uveitis

description: Images were obtained from the eyes of anaesthetised mice using the Micron IV retinal imaging microscope. Spectral domain optical coherence tomography (OCT) images were obtained as 512 serial B-scans of a volume of tissue centred on the optic nerve head. Prior to imaging the Micron IV was fully calibrated according to the manufacturer’s protocol. Images (512x1024 pixels) with a bit depth of 16 were acquired using PackBits lossless compression. Experimental autoimmune uveitis (EAU) was induced in all animals by the transfer of disease causing CD4+ T lymphocytes specific for the retinal binding protein-3 (also known as IRBP) peptide 639-643 (EAHYARPEIAQRARA), (cf. Boldison et al. (2015)). Cells were transferred on day 0 (D0) after baseline imaging. Selected animals were imaged at subsequent time points (days 2, 6/7, 14) after cell transfer. In this model, disease characterised by an influx of cells into the eye and alteration in the retinal morphology, is clinically silent at day 2 and reaches a peak between day 6 and 14. The scans from each volume are recorded in a single folder whose name indicates the experiment, day of acquisition and individual animal. For example ‘TX12_D0_A1L’ is a scan of the left eye of mouse A1 obtained on day 0 of experiment Tx12. All experiments involving animals were conducted under licence from the United Kingdom Home Office and were approved by the University of Bristol Ethical Review Group. The studies also complied with the Association for Research in Vision and Ophthalmology (ARVO) Statement for the Use of Animals in Ophthalmic and Visual Research.
DOI: 10.6084/m9.figshare.21707930
title: DataXprt.xls

description: Contain Xpert Data 9 x 75 Matrix, 3x75 is X then 6x75 is V for the two observers
DOI: 10.6084/m9.figshare.21707933
title: DataNaive.xls

description: Contain Naive Data 69 x 12 Matrix, 3x12 is X then 66x12 is V for the 22 observers
DOI: 10.6084/m9.figshare.22180186
title: Wigner_functions.zip

description: Wigner functions, which are reconstructed from the experiments and the simulations.
DOI: 10.6084/m9.figshare.22819754
title: Dataset 1.zip

description: Opto-microfluidic coupling between optical waveguides and tilted microchannels in lithium niobate
DOI: 10.6084/m9.figshare.24482440
title: Bedggood_Dataset1.csv

description: A series of measurements made on 121 unique capillary segments imaged in the living human retina of 3 human subjects. Each measurement applies to the "average red blood cell" observed within that vessel over a measuring period of approx. 1-3 sec. Estimates include cell volume and surface area, lumen diameter, orientation, inter-cellular separation, and velocity measurements.
DOI: 10.6084/m9.figshare.24570337
title: Proteostasis perturbation of N-Myc leveraging HSP70 mediated protein turnover improves treatment of neuroendocrine prostate cancer

description: Whole exome sequencing (WES) and data from patient, PDX, and cell line.
DOI: 10.6084/m9.figshare.24870666
title: Supporting information: Energy dissipation during shear along experimental rough faults

description: Supporting information: Energy dissipation during shear along experimental rough faults
DOI: 10.6084/m9.figshare.24961860
title: Supplementary Material for: Transarterial Chemoembolization Combined with Lenvatinib for Hepatocellular Carcinoma: A Systematic Review and Meta-analysis of Randomized Controlled Trials

description: Introduction: The treatment of hepatocellular carcinoma (HCC) with transarterial chemoembolization (TACE) and lenvatinib individually has shown favorable outcomes, but there is currently no meta-analysis based on randomized controlled trials (RCTs) to investigate the efficacy and safety of this combined treatment for HCC. The aim of this study is to identify the efficacy and safety of TACE plus lenvatinib for the treatment of HCC. 
Methods: A systematic search of MEDLINE (via PubMed), the Cochrane Library, EMBASE, and the Web of Science was conducted on July 31, 2023. RCTs evaluating the efficacy and safety of TACE in combination with lenvatinib for the treatment of HCC were included. The risk of bias in the included studies was assessed using the Risk of Bias 2 tool. Outcome measures such as objective response rate (ORR), CR (complete remission), progression-free survival (PFS), overall survival (OS), and safety parameters were extracted from the included studies. Binary outcomes were analyzed using odds ratio (OR), risk ratio (RR), or hazard ratio (HR), while continuous variables were analyzed using mean difference (MD) or standardized MD (SMD) in Rstudio. The quality of the evidence was graded using the GRADE approach. Heterogeneity was considered significant when the I-squared was 50% or less. 
Results: Five RCTs involving 638 patients were included. The meta-analysis revealed that patients in the TACE plus lenvatinib group had a significantly higher mean ORR compared to the control group (OR: 3.65, 95% CI: 2.50–5.32, fixed effects model; OR: 3.58, 95% CI: 2.45–5.24, random effects model, I2 = 0, moderate quality). Specifically, 40.9% of patients in the TACE plus lenvatinib group achieved a PR, which was significantly higher than the control group (OR: 3.51, 95% CI: 2.41–5.13, fixed effects model; OR: 3.46, 95% CI: 2.36–5.07, random effects model, I2 = 0, moderate quality). The HR for OS was 0.47 (95% CI: 0.35–0.62, fixed effects model and random effects model, I2 = 0, moderate quality). The meta-analysis revealed that the TACE plus lenvatinib group had a significantly higher total adverse effects rate than the control group (OR: 1.86, 95% CI: 1.01–3.43, fixed effects model; OR: 1.85, 95% CI: 1.00–3.43, random effects model, I2 = 0, moderate quality).
Conclusion: Our study suggests that the combination of TACE and lenvatinib in the treatment of HCC has shown promising results, with extended OS and improved ORR.
DOI: 10.6084/m9.figshare.25493827.v2
title: Paper Data & Data Processing Files for TheissCuffeyZhao2024

description: Subglacial quarrying, thought to be dependent on basal sliding speed, effective pressure, and other factors contributing to normal load concentrations from ice on bedrock, is a significant contributor to subglacial erosion and promotes basal bedrock roughness, which limits how quickly glaciers can slide into the net mass loss zone. The data we provide here are a result of numerous load tests generating mixed-mode stress intensity factor concentrations on crack tips in bedrock steps typical of subglacial or deglaciated landscapes. In the corresponding paper, we explain the significance of each geometric variable and the implications for the favorability of existing cracks to grow. We combine our stress intensity factors into a growth rate index normalized to the ice load so others may consider a variety of hypothesized conditions. In the supplement we expand on the current state of potential subglacial normal and shear loads, provide additional results for the variables covered in the paper, and show the outcomes of various sensitivity tests.