cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.15468/dl.t6vqst
title: Occurrence Download

description: A dataset containing 7529 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is one of (South Africa, Lesotho, Eswatini)",
 "TaxonKey is one of (Ploceus xanthops (Hartlaub, 1862))",
 "BasisOfRecord is one of (Human Observation, Observation)",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "Year is greater than or equal to 1950",
 "OccurrenceStatus is Present",
 "DistanceFromCentroidInMeters is greater than or equal to 2000"
 ]
}

 The dataset includes 7529 records from 8 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0003776-250117142028555/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.ezpke9
title: Occurrence Download

description: A dataset containing 49219 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is one of (South Africa, Lesotho, Eswatini)",
 "TaxonKey is one of (Ardea purpurea Linnaeus, 1766)",
 "BasisOfRecord is one of (Human Observation, Observation)",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "Year is greater than or equal to 1950",
 "OccurrenceStatus is Present",
 "DistanceFromCentroidInMeters is greater than or equal to 2000"
 ]
}

 The dataset includes 49219 records from 11 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0003777-250117142028555/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.26187/deakin.27923379
title: A Simple Emulsion for Measuring Fat Taste Sensitivity

description: Dataset for manuscript titled A Simple Emulsion for Measuring Fat Taste Sensitivity.Categorical variables are defined at the bottom of the respective rows.
DOI: 10.26187/deakin.27923379.v2
title: A Simple Emulsion for Measuring Fat Taste Sensitivity

description: Dataset for manuscript titled A Simple Emulsion for Measuring Fat Taste Sensitivity.Categorical variables are defined at the bottom of the respective rows.
DOI: 10.26187/deakin.27923379.v1
title: A Simple Emulsion for Measuring Fat Taste Sensitivity

description: Dataset for manuscript titled A Simple Emulsion for Measuring Fat Taste Sensitivity (to be submitted to Food Research International)
DOI: 10.15468/dl.sucycj
title: Occurrence Download

description: A dataset containing 37005 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is one of (South Africa, Lesotho, Eswatini)",
 "TaxonKey is one of (Euplectes afer (Gmelin, 1789))",
 "BasisOfRecord is one of (Human Observation, Observation)",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "Year is greater than or equal to 1950",
 "OccurrenceStatus is Present",
 "DistanceFromCentroidInMeters is greater than or equal to 2000"
 ]
}

 The dataset includes 37005 records from 9 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0003779-250117142028555/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.nsh2vp
title: Occurrence Download

description: A dataset containing 12072 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is one of (South Africa, Lesotho, Eswatini)",
 "TaxonKey is one of (Thalassornis leuconotus Eyton, 1838)",
 "BasisOfRecord is one of (Human Observation, Observation)",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "Year is greater than or equal to 1950",
 "OccurrenceStatus is Present",
 "DistanceFromCentroidInMeters is greater than or equal to 2000"
 ]
}

 The dataset includes 12072 records from 10 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0003780-250117142028555/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.6j8mjt
title: Occurrence Download

description: A dataset containing 11086859 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is Mexico",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "Month is one of (January, February, March, April, May, June, July, August, September, October, November, December)",
 "Year 2020-2025"
 ]
}

 The dataset includes 11086859 records from 225 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0003775-250117142028555/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.2dm9q3
title: Occurrence Download

description: A dataset containing 65796 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is one of (South Africa, Lesotho, Eswatini)",
 "TaxonKey is one of (Erythropygia coryphoeus (Vieillot, 1817))",
 "BasisOfRecord is one of (Human Observation, Observation)",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "Year is greater than or equal to 1950",
 "OccurrenceStatus is Present",
 "DistanceFromCentroidInMeters is greater than or equal to 2000"
 ]
}

 The dataset includes 65796 records from 7 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0003781-250117142028555/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.5fxcwq
title: Occurrence Download

description: A dataset listing the 1 species recorded in GBIF matching the query:
{
 "TaxonKey" : [
 "is Agapornis taranta (Stanley, 1814)"
 ]
}

 The dataset's 1 records were derived from 47 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0003774-250117142028555/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.cspz4f
title: Occurrence Download

description: A dataset containing 8305 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is one of (South Africa, Lesotho, Eswatini)",
 "TaxonKey is one of (Lissotis melanogaster (Ruppell, 1835))",
 "BasisOfRecord is one of (Human Observation, Observation)",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "Year is greater than or equal to 1950",
 "OccurrenceStatus is Present",
 "DistanceFromCentroidInMeters is greater than or equal to 2000"
 ]
}

 The dataset includes 8305 records from 9 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0003783-250117142028555/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.yh7hj9
title: Occurrence Download

description: A dataset containing 5171 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is one of (South Africa, Lesotho, Eswatini)",
 "TaxonKey is one of (Vanellus lugubris (R.Lesson, 1826))",
 "BasisOfRecord is one of (Human Observation, Observation)",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "Year is greater than or equal to 1950",
 "OccurrenceStatus is Present",
 "DistanceFromCentroidInMeters is greater than or equal to 2000"
 ]
}

 The dataset includes 5171 records from 9 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0003784-250117142028555/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.6084/m9.figshare.28237142
title: Data from: You sound like my Mr. Right: female frogs choose size-assortative mates through acoustic features

description: 1. Amplexus is a distinctive mating strategy in the reproductive life cycle of amphibians, during which females may adopt assortative or random mating strategies in selecting mates. Prior to amplexus, male frogs usually emit acoustic signals to attract females, emphasizing the predominant role of acoustic communication in anuran reproductive process. However, it has remained unclear whether males' acoustic signals significantly affect female’s preference for male size.2. In this study, we investigated the mating strategy of Fejervarya multistriata, a paddy frog, and examined whether females can use acoustic signals to locate assortatively-sized males. We measured the body size of frog amplexus pairs to explore the relationship between female and male body size. We then recorded male advertisement calls and employed stepwise algorithm to optimize a linear model for predicting male size based on acoustic properties, identifying the properties that most effectively predict male size. We also conducted two-choice arena phonotaxis experiments in which females were simultaneously exposed to male calls representing different body sizes.3. Our findings showed that: (1) F. multistriata could use size-assortative mating as a reproductive strategy. (2) The optimal acoustic-morphometric model, incorporating the first frequency band and note interval that both negatively correlated with male size, could accurately predict male body size. (3) Female frogs exhibited preferences for calls representing size-assortative males.4. Therefore, we suggested that F. multistriata females can use acoustic signals to discriminate between males of different sizes, supporting an acoustically-mediated size-assortative mating strategy. In conclusion, this study provides valuable insights into the mechanisms of size-assortative mate choice in amphibians and contributes to understanding the role of acoustic signals in reproductive processes.
DOI: 10.15468/dl.9pv5w4
title: Occurrence Download

description: A dataset containing 55596 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is one of (South Africa, Lesotho, Eswatini)",
 "TaxonKey is one of (Lanius collurio Linnaeus, 1758)",
 "BasisOfRecord is one of (Human Observation, Observation)",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "Year is greater than or equal to 1950",
 "OccurrenceStatus is Present",
 "DistanceFromCentroidInMeters is greater than or equal to 2000"
 ]
}

 The dataset includes 55596 records from 9 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0003785-250117142028555/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.ms4hrv
title: Occurrence Download

description: A dataset containing 50323 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is one of (South Africa, Lesotho, Eswatini)",
 "TaxonKey is one of (Phalacrocorax capensis (Sparrman, 1788))",
 "BasisOfRecord is one of (Human Observation, Observation)",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "Year is greater than or equal to 1950",
 "OccurrenceStatus is Present",
 "DistanceFromCentroidInMeters is greater than or equal to 2000"
 ]
}

 The dataset includes 50323 records from 12 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0003787-250117142028555/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.v9vqy7
title: Occurrence Download

description: A dataset containing 7281 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is one of (South Africa, Lesotho, Eswatini)",
 "TaxonKey is one of (Sarothrura rufa (Vieillot, 1819))",
 "BasisOfRecord is one of (Human Observation, Observation)",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "Year is greater than or equal to 1950",
 "OccurrenceStatus is Present",
 "DistanceFromCentroidInMeters is greater than or equal to 2000"
 ]
}

 The dataset includes 7281 records from 8 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0003788-250117142028555/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.jwjxx7
title: Occurrence Download

description: A dataset containing 56 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Geometry POLYGON((-88.06113 19.92651,-86.63281 19.92651,-86.63281 21.52949,-88.06113 21.52949,-88.06113 19.92651))",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 "TaxonKey is Panthera onca (Linnaeus, 1758)",
 "Year 2010-2025"
 ]
}

 The dataset includes 56 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0003789-250117142028555/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.6084/m9.figshare.25027434
title: Factors associated with immune-related thyroid dysfunction induced by PD-1/PD-L1 inhibitors in cancer patients: an observational study

description: This study aimed to identify the potential factors associated with immune thyroid dysfunction caused by programmed death 1 (PD-1)/programmed death ligand 1 (PD-L1) inhibitors in cancer patients. We conducted a retrospective study of thyroid immune-related adverse events (irAEs) in cancer patients treated with PD-1/PD-L1 inhibitors at Tianjin First Central Hospital from January 2020 to March 2023. Thyroid irAEs were characterized as hypothyroidism, hyperthyroidism and thyrotoxicosis followed by hypothyroidism. A total of 175 patients were screened in the study, of whom 48 patients (27%) developed thyroid irAEs (including 24 hypothyroidism, 11 hyperthyroidism and 13 thyrotoxicosis followed by hypothyroidism) following PD-1/PD-L1 inhibitors treatment. Multivariate logistic regression analysis showed that combination therapy with PD-1/PD-L1 inhibitors and tyrosine kinase inhibitors (lenvatinib/regorafenib) and high baseline anti-TPO level were associated with the development of thyroid irAEs caused by PD-1/PD-L1 inhibitors. The nomogram models showed good discriminant ability and could bring net benefits for more patients according to the decision curve analysis. However, the model needs to be further validated in other large cohorts.
DOI: 10.6084/m9.figshare.25027434.v1
title: Factors associated with immune-related thyroid dysfunction induced by PD-1/PD-L1 inhibitors in cancer patients: an observational study

description: This study aimed to identify the potential factors associated with immune thyroid dysfunction caused by programmed death 1 (PD-1)/programmed death ligand 1 (PD-L1) inhibitors in cancer patients. We conducted a retrospective study of thyroid immune-related adverse events (irAEs) in cancer patients treated with PD-1/PD-L1 inhibitors at Tianjin First Central Hospital from January 2020 to March 2023. Thyroid irAEs were characterized as hypothyroidism, hyperthyroidism and thyrotoxicosis followed by hypothyroidism. A total of 175 patients were screened in the study, of whom 48 patients (27%) developed thyroid irAEs (including 24 hypothyroidism, 11 hyperthyroidism and 13 thyrotoxicosis followed by hypothyroidism) following PD-1/PD-L1 inhibitors treatment. Multivariate logistic regression analysis showed that combination therapy with PD-1/PD-L1 inhibitors and tyrosine kinase inhibitors (lenvatinib/regorafenib) and high baseline anti-TPO level were associated with the development of thyroid irAEs caused by PD-1/PD-L1 inhibitors. The nomogram models showed good discriminant ability and could bring net benefits for more patients according to the decision curve analysis. However, the model needs to be further validated in other large cohorts.
DOI: 10.6084/m9.figshare.25670855.v1
title: Evaluation of omadacycline regimens for community-acquired bacterial pneumonia patients infected with <i>Staphylococcus Aureus</i> by pharmacokinetic/pharmacodynamic analysis

description: Omadacycline is an FDA-approved agent for community-acquired bacterial pneumonia (CABP). The purpose of this study is to evaluate the effectiveness of omadacycline for treating CABP patients infected with <i>Staphylococcus aureus</i>, including Methicillin-Resistant <i>Staphylococcus aureus</i> (MRSA) and Methicillin-Susceptible <i>Staphylococcus aureus</i> (MSSA), using pharmacokinetic/pharmacodynamic (PK/PD) analysis. Monte Carlo simulations (MCSs) were performed by utilizing omadacycline pharmacokinetic (PK) parameters, minimum inhibitory concentration (MIC) data, and <i>in vivo</i> PK/PD targets to calculate the probability of target attainment (PTA) and cumulative fraction of response (CFR) values for different dose regimens against MRSA and MSSA in CABP patients. A dosage regimen with a PTA or CFR expectation value greater than 90% was considered optimal. For all recommended dose regimens, PTA values for MRSA MIC ≤1 and MSSA MIC ≤4 on days 1, 4, and 7 were greater than 90%. Based on the MIC distribution of <i>Staphylococcus aureus</i>, all dose regimens had CFR values greater than 90% for both MRSA and MSSA. CFR values for different bacterial strains were still greater than 90% within the range of PK/PD target values less than 40, although they gradually decreased with increasing PK/PD target values. PK/PD modeling demonstrated that all recommended dose regimens of omadacycline are highly effective against CABP patients infected with MRSA and MSSA. The study provides theoretical support for the efficacy of omadacycline in different dose regimens.
DOI: 10.6084/m9.figshare.25755894
title: Blocking lncRNA HCG18 re-sensitizes Taxol resistant lung cancer cells to Taxol through modulating the miR-34a-5p/HDAC1 axis

description: Lung cancer is one of the most frequently diagnosed cancers worldwide, associated with a poor survival rate. Taxol (Paclitaxel) is commonly used as a chemotherapeutic treatment for advanced lung cancers. While Taxol has improved clinical outcomes for lung cancer patients, a significant number of them develop resistance to Taxol, resulting in treatment failure. The role of the long noncoding RNA HCG18 in lung cancer and Taxol resistance has not yet been fully understood. To investigate this, we examined the expression of HCG18 and miR-34a-5p in lung tumors and normal lung tissues using qRT-PCR. We also assessed Taxol resistance through cell viability and apoptosis assays. Through the starBase online service, we analyzed the interactions between lncRNA and mRNA as well as miRNA and mRNA. We further validated the association between lncRNA and miRNA through luciferase and RNA pull-down assays. Our findings demonstrated that HCG18 was significantly upregulated in lung cancer tissues compared to normal lung tissues. Silencing HCG18 increased the sensitivity of lung cancer cells to Taxol. Additionally, our study established a Taxol-resistant cell line and observed a substantial upregulation of HCG18 in Taxol-resistant lung cancer cells. Bioinformatic analysis predicted that HCG18 could bind to miR-34a-5p, forming a competing endogenous RNA network, which was confirmed through luciferase assay. We found that miR-34a-5p was downregulated in lung cancer tissues and negatively correlated with Taxol resistance, as it directly bound to the 3’UTR region of HDAC1. Further results showed that inhibition of HCG18 significantly increased miR-34a-5p expression and sensitized lung cancer cells to Taxol. This sensitization could be reversed by inhibiting miR-34a-5p. Finally, we demonstrated in a xenograft mouse model that inhibition of HCG18 sensitized Taxol-resistant lung cancer cells to Taxol treatment by modulating the miR-34a-5p-HDAC1 axis. In conclusion, our in vitro and in vivo results uncover a novel molecular mechanism by which HCG18 promotes Taxol resistance through modulation of the miR-34a-5p/HDAC1 axis. These findings contribute to the diagnosis and treatment of chemo-resistant lung cancer.
DOI: 10.6084/m9.figshare.25670855
title: Evaluation of omadacycline regimens for community-acquired bacterial pneumonia patients infected with <i>Staphylococcus Aureus</i> by pharmacokinetic/pharmacodynamic analysis

description: Omadacycline is an FDA-approved agent for community-acquired bacterial pneumonia (CABP). The purpose of this study is to evaluate the effectiveness of omadacycline for treating CABP patients infected with <i>Staphylococcus aureus</i>, including Methicillin-Resistant <i>Staphylococcus aureus</i> (MRSA) and Methicillin-Susceptible <i>Staphylococcus aureus</i> (MSSA), using pharmacokinetic/pharmacodynamic (PK/PD) analysis. Monte Carlo simulations (MCSs) were performed by utilizing omadacycline pharmacokinetic (PK) parameters, minimum inhibitory concentration (MIC) data, and <i>in vivo</i> PK/PD targets to calculate the probability of target attainment (PTA) and cumulative fraction of response (CFR) values for different dose regimens against MRSA and MSSA in CABP patients. A dosage regimen with a PTA or CFR expectation value greater than 90% was considered optimal. For all recommended dose regimens, PTA values for MRSA MIC ≤1 and MSSA MIC ≤4 on days 1, 4, and 7 were greater than 90%. Based on the MIC distribution of <i>Staphylococcus aureus</i>, all dose regimens had CFR values greater than 90% for both MRSA and MSSA. CFR values for different bacterial strains were still greater than 90% within the range of PK/PD target values less than 40, although they gradually decreased with increasing PK/PD target values. PK/PD modeling demonstrated that all recommended dose regimens of omadacycline are highly effective against CABP patients infected with MRSA and MSSA. The study provides theoretical support for the efficacy of omadacycline in different dose regimens.
DOI: 10.6084/m9.figshare.25755894.v1
title: Blocking lncRNA HCG18 re-sensitizes Taxol resistant lung cancer cells to Taxol through modulating the miR-34a-5p/HDAC1 axis

description: Lung cancer is one of the most frequently diagnosed cancers worldwide, associated with a poor survival rate. Taxol (Paclitaxel) is commonly used as a chemotherapeutic treatment for advanced lung cancers. While Taxol has improved clinical outcomes for lung cancer patients, a significant number of them develop resistance to Taxol, resulting in treatment failure. The role of the long noncoding RNA HCG18 in lung cancer and Taxol resistance has not yet been fully understood. To investigate this, we examined the expression of HCG18 and miR-34a-5p in lung tumors and normal lung tissues using qRT-PCR. We also assessed Taxol resistance through cell viability and apoptosis assays. Through the starBase online service, we analyzed the interactions between lncRNA and mRNA as well as miRNA and mRNA. We further validated the association between lncRNA and miRNA through luciferase and RNA pull-down assays. Our findings demonstrated that HCG18 was significantly upregulated in lung cancer tissues compared to normal lung tissues. Silencing HCG18 increased the sensitivity of lung cancer cells to Taxol. Additionally, our study established a Taxol-resistant cell line and observed a substantial upregulation of HCG18 in Taxol-resistant lung cancer cells. Bioinformatic analysis predicted that HCG18 could bind to miR-34a-5p, forming a competing endogenous RNA network, which was confirmed through luciferase assay. We found that miR-34a-5p was downregulated in lung cancer tissues and negatively correlated with Taxol resistance, as it directly bound to the 3’UTR region of HDAC1. Further results showed that inhibition of HCG18 significantly increased miR-34a-5p expression and sensitized lung cancer cells to Taxol. This sensitization could be reversed by inhibiting miR-34a-5p. Finally, we demonstrated in a xenograft mouse model that inhibition of HCG18 sensitized Taxol-resistant lung cancer cells to Taxol treatment by modulating the miR-34a-5p-HDAC1 axis. In conclusion, our in vitro and in vivo results uncover a novel molecular mechanism by which HCG18 promotes Taxol resistance through modulation of the miR-34a-5p/HDAC1 axis. These findings contribute to the diagnosis and treatment of chemo-resistant lung cancer.