cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.4836101
title: Metabolic effects of aspartame in adulthood: A systematic review and meta-analysis of randomized clinical trials

description: Data about harms or benefits associated with the consumption of aspartame, a nonnutritive sweetener worldwide consumed, are still controversial. This systematic review and meta-analysis of randomized controlled clinical trials aimed to assess the effect of aspartame consumption on metabolic parameters related to diabetes and obesity. The search was performed on Cochrane, LILACS, PubMed, SCOPUS, Web of Science databases, and on a gray literature using Open Grey, Google Scholar, and ProQuest Dissertations & Theses Global. Searches across all databases were conducted from the earliest available date up to April 13, 2016, without date and language restrictions. Pooled mean differences were calculated using a random or fixed-effects model for heterogeneous and homogenous studies, respectively. Twenty-nine articles were included in qualitative synthesis and twelve, presenting numeric results, were used in meta-analysis. Fasting blood glucose (mmol/L), insulin levels (μU/mL), total cholesterol (mmol/L), triglycerides concentrations (mmol/L), high-density lipoprotein cholesterol (mmol/L), body weight (kg), and energy intake (MJ) were considered as the main outcomes in subjects that consumed aspartame, and results were presented as mean difference; % confidence interval, range. Aspartame consumption was not associated with alterations on blood glucose levels compared to control (−0.03 mmol/L; 95% CI, −0.21 to 0.14) or to sucrose (0.31 mmol/L; 95% CI, −0.05 to 0.67) and on insulin levels compared to control (0.13 μU/mL; 95% CI, −0.69 to 0.95) or to sucrose (2.54 μU/mL; 95% CI, −6.29 to 11.37). Total cholesterol was not affected by aspartame consumption compared to control (−0.02 mmol/L; 95% CI, −0.31 to 0.27) or to sucrose (−0.24 mmol/L; 95% CI, −0.89 to 0.42). Triglycerides concentrations were not affected by aspartame consumption compared to control (0.00 mmol/L; 95% CI, −0.04 to 0.05) or to sucrose (0.00 mmol/L; 95% CI, −0.09 to 0.09). High-density lipoprotein cholesterol serum levels were higher on aspartame compared to control (−0.03 mmol/L; 95% CI, −0.06 to −0.01) and lower on aspartame compared to sucrose (0.05 mmol/L; 95% CI, 0.02 to 0.09). Body weight did not change after aspartame consumption compared to control (5.00 kg; 95% CI, −1.56 to 11.56) or to sucrose (3.78 kg; 95% CI, −2.18 to 9.74). Energy intake was not altered by aspartame consumption compared to control (−0.49 MJ; 95% CI, −1.21 to 0.22) or to sucrose (−0.17 MJ; 95% CI, −2.03 to 1.69). Data concerning effects of aspartame on main metabolic variables associated to diabetes and obesity do not support a beneficial related to its consumption.
DOI: 10.6084/m9.figshare.4836110.v2
title: A Novel Approach for Markov Random Field With Intractable Normalizing Constant on Large Lattices

description: The pseudo likelihood method of Besag (1974) has remained a popular method for estimating Markov random field on a very large lattice, despite various documented deficiencies. This is partly because it remains the only computationally tractable method for large lattices. We introduce a novel method to estimate Markov random fields defined on a regular lattice. The method takes advantage of conditional independence structures and recursively decomposes a large lattice into smaller sublattices. An approximation is made at each decomposition. Doing so completely avoids the need to compute the troublesome normalizing constant. The computational complexity is <i>O</i>(<i>N</i>), where <i>N</i> is the number of pixels in the lattice, making it computationally attractive for very large lattices. We show through simulations, that the proposed method performs well, even when compared with methods using exact likelihoods. Supplementary material for this article is available online.
DOI: 10.6084/m9.figshare.4836104.v2
title: A Nonparametric Adaptive Sampling Strategy for Online Monitoring of Big Data Streams

description: With the rapid advancement of sensor technology, a huge amount of data is generated in various applications, which poses new and unique challenges for statistical process control (SPC). In this article, we propose a nonparametric adaptive sampling (NAS) strategy to online monitor nonnormal big data streams in the context of limited resources, where only a subset of observations are available at each acquisition time. In particular, this proposed method integrates a rank-based CUSUM scheme and an innovative idea that corrects the anti-rank statistics with partial observations, which can effectively detect a wide range of possible mean shifts when data streams are exchangeable and follow arbitrary distributions. Two theoretical properties on the sampling layout of the proposed NAS algorithm are investigated when the process is in control and out of control. Both simulations and case studies are conducted under different scenarios to illustrate and evaluate the performance of the proposed method. Supplementary materials for this article are available online.
DOI: 10.6084/m9.figshare.4836191.v3
title: Outcomes of a user testing session involving six users in writing a scholarly article with RAJE

description: Outcomes of experimenting RASH Javascript Editor (RAJE)<br><br>These are the outcome results of the first RAJE test. All testers are anonymous.<br><br>Content of the archive:<br>1. <b>background.csv</b> It contains the answers from testers about own background experience<br>2. <b>sus.csv</b> It contains the answers of SUS questions<br>3. <b>grounded_analysis.ods</b> It contains the raw-text answers to capture feedback and produce the grounded analysis, and the result tables (with micro and macro cateogries).<br>4. <b>result_screens/</b> It is a folder containing the screenshots of the result scripts.<br><br>
DOI: 10.6084/m9.figshare.4836104.v1
title: A Nonparametric Adaptive Sampling Strategy for Online Monitoring of Big Data Streams

description: With the rapid advancement of sensor technology, a huge amount of data is generated in various applications, which poses new and unique challenges for Statistical Process Control (SPC). In this paper, we propose a Nonparametric Adaptive Sampling (NAS) strategy to online monitor non-normal big data streams in the context of limited resources, where only a subset of observations are available at each acquisition time. In particular, this proposed method integrates a rank-based CUSUM scheme and an innovative idea that corrects the anti-rank statistics with partial observations, which can effectively detect a wide range of possible mean shifts when data streams are exchangeable and follow arbitrary distributions. Two theoretical properties on the sampling layout of the proposed NAS algorithm are investigated when the process is in control and out of control. Both simulations and case studies are conducted under different scenarios to illustrate and evaluate the performance of the proposed method.
DOI: 10.6084/m9.figshare.4836191.v2
title: Outcomes of a user testing session involving six users in writing a scholarly article with RAJE

description: Outcomes of experimenting RASH Javascript Editor (RAJE)<br><br>These are the outcome results of the first RAJE test. All testers are anonymous.<br><br>Content of the archive:<br>1. <b>background.csv</b> It contains the answers from testers about own background experience<br>2. <b>sus.csv</b> It contains the answers of SUS questions<br>3. <b>grounded_analysis.ods</b> It contains the raw-text answers to capture feedback and produce the grounded analysis, and the result tables (with micro and macro cateogries).<br>4. <b>result_screens/</b> It is a folder containing the screenshots of the result scripts.<br><br>
DOI: 10.6084/m9.figshare.4836110.v1
title: A novel approach for Markov random field with intractable normalizing constant on large lattices

description: The pseudo likelihood method of (Besag, 1974) has remained a popular method for estimating Markov random field on a very large lattice, despite various documented deficiencies. This is partly because it remains the only computationally tractable method for large lattices. We introduce a novel method to estimate Markov random fields defined on a regular lattice. The method takes advantage of conditional independence structures and recursively decomposes a large lattice into smaller sublattices. An approximation is made at each decomposition. Doing so completely avoids the need to compute the troublesome normalizing constant. The computational complexity is <i>O</i>(<i>N</i>), where <i>N</i> is the the number of pixels in the lattice, making it computationally attractive for very large lattices. We show through simulations, that the proposed method performs well, even when compared to the methods using exact likelihoods.
DOI: 10.6084/m9.figshare.4835963
title: New protocol based on massive parallel sequencing for aneuploidy screening of preimplantation human embryos

description: Novel next-generation sequencing procedures have rapidly emerged into the preimplantation genetic screening framework. This work presents the design and validation of a new low-coverage whole-genome sequencing assay for aneuploidy detection in single blastomeres and trophectodermal samples from preimplantation embryos. The validation ensures analytical sensitivity, specificity, robustness, precision, limit of detection, resolution, and reproducibility. Specific parameters to measure the performance are defined, and the results are compared with a standardized array-based method to stablish the concordance. From the single cell genomics point of view, the main novelties are the length of reads of the libraries (150 nucleotides) together with a paired-end strategy and the design of an original algorithm and copy number viewer. A total of 129 samples were included in six experimental runs using a MiSeq Illumina platform. Samples included: single amniocytes, single blastomeres (cleavage-stage embryos), trophectoderm samples (blastocyst), and diluted DNA. Sensitivity and specificity were calculated per chromosome yielding 96% and 99%, respectively. The percentage of concordant samples was 98.2% and all of the aneuploid samples were confirmed. In conclusion, the validation yields highly reliable and reproducible results, representing an accurate and cost-effective strategy for the routine detection of aneuploidy in human embryos.
DOI: 10.6084/m9.figshare.4835963.v1
title: New protocol based on massive parallel sequencing for aneuploidy screening of preimplantation human embryos

description: Novel next-generation sequencing procedures have rapidly emerged into the preimplantation genetic screening framework. This work presents the design and validation of a new low-coverage whole-genome sequencing assay for aneuploidy detection in single blastomeres and trophectodermal samples from preimplantation embryos. The validation ensures analytical sensitivity, specificity, robustness, precision, limit of detection, resolution, and reproducibility. Specific parameters to measure the performance are defined, and the results are compared with a standardized array-based method to stablish the concordance. From the single cell genomics point of view, the main novelties are the length of reads of the libraries (150 nucleotides) together with a paired-end strategy and the design of an original algorithm and copy number viewer. A total of 129 samples were included in six experimental runs using a MiSeq Illumina platform. Samples included: single amniocytes, single blastomeres (cleavage-stage embryos), trophectoderm samples (blastocyst), and diluted DNA. Sensitivity and specificity were calculated per chromosome yielding 96% and 99%, respectively. The percentage of concordant samples was 98.2% and all of the aneuploid samples were confirmed. In conclusion, the validation yields highly reliable and reproducible results, representing an accurate and cost-effective strategy for the routine detection of aneuploidy in human embryos.
DOI: 10.6084/m9.figshare.4836101.v2
title: Metabolic effects of aspartame in adulthood: A systematic review and meta-analysis of randomized clinical trials

description: Data about harms or benefits associated with the consumption of aspartame, a nonnutritive sweetener worldwide consumed, are still controversial. This systematic review and meta-analysis of randomized controlled clinical trials aimed to assess the effect of aspartame consumption on metabolic parameters related to diabetes and obesity. The search was performed on Cochrane, LILACS, PubMed, SCOPUS, Web of Science databases, and on a gray literature using Open Grey, Google Scholar, and ProQuest Dissertations & Theses Global. Searches across all databases were conducted from the earliest available date up to April 13, 2016, without date and language restrictions. Pooled mean differences were calculated using a random or fixed-effects model for heterogeneous and homogenous studies, respectively. Twenty-nine articles were included in qualitative synthesis and twelve, presenting numeric results, were used in meta-analysis. Fasting blood glucose (mmol/L), insulin levels (μU/mL), total cholesterol (mmol/L), triglycerides concentrations (mmol/L), high-density lipoprotein cholesterol (mmol/L), body weight (kg), and energy intake (MJ) were considered as the main outcomes in subjects that consumed aspartame, and results were presented as mean difference; % confidence interval, range. Aspartame consumption was not associated with alterations on blood glucose levels compared to control (−0.03 mmol/L; 95% CI, −0.21 to 0.14) or to sucrose (0.31 mmol/L; 95% CI, −0.05 to 0.67) and on insulin levels compared to control (0.13 μU/mL; 95% CI, −0.69 to 0.95) or to sucrose (2.54 μU/mL; 95% CI, −6.29 to 11.37). Total cholesterol was not affected by aspartame consumption compared to control (−0.02 mmol/L; 95% CI, −0.31 to 0.27) or to sucrose (−0.24 mmol/L; 95% CI, −0.89 to 0.42). Triglycerides concentrations were not affected by aspartame consumption compared to control (0.00 mmol/L; 95% CI, −0.04 to 0.05) or to sucrose (0.00 mmol/L; 95% CI, −0.09 to 0.09). High-density lipoprotein cholesterol serum levels were higher on aspartame compared to control (−0.03 mmol/L; 95% CI, −0.06 to −0.01) and lower on aspartame compared to sucrose (0.05 mmol/L; 95% CI, 0.02 to 0.09). Body weight did not change after aspartame consumption compared to control (5.00 kg; 95% CI, −1.56 to 11.56) or to sucrose (3.78 kg; 95% CI, −2.18 to 9.74). Energy intake was not altered by aspartame consumption compared to control (−0.49 MJ; 95% CI, −1.21 to 0.22) or to sucrose (−0.17 MJ; 95% CI, −2.03 to 1.69). Data concerning effects of aspartame on main metabolic variables associated to diabetes and obesity do not support a beneficial related to its consumption.
DOI: 10.6084/m9.figshare.4835942
title: index.html

description: SMS - RE for robotics
DOI: 10.6084/m9.figshare.4836101.v1
title: Metabolic effects of aspartame in adulthood: a systematic review and meta-analysis of randomized clinical trials

description: <b>Background</b>: Data about harms or benefits associated with the consumption of aspartame, a non-nutritive sweetener worldwide consumed, is still controversial. This systematic review and meta-analysis of randomized controlled clinical trials aimed to assess the effect of aspartame consumption on metabolic parameters related to diabetes and obesity. <b>Methods</b>: The search was performed on Cochrane, LILACS, PubMed, SCOPUS, Web of Science databases and on a grey literature using Open Grey, Google Scholar and ProQuest Dissertations & Theses Global. Searches across all databases were conducted from the earliest available date up to April 13, 2016, without date and language restrictions. Pooled mean differences were calculated using a random or fixed-effects model for heterogeneous and homogenous studies, respectively. <b>Results</b>: Twenty nine articles were included in qualitative synthesis and twelve, presenting numeric results, were used in meta-analysis. Fasting blood glucose (mmol/L), insulin levels (μU/mL), total cholesterol (mmol/L), triglycerides concentrations (mmol/L), high-density lipoprotein cholesterol (mmol/L), body weight (Kg) and energy intake (MJ) were considered as the main outcomes in subjects that consumed aspartame and results were presented as (mean difference; % Confidence Interval, range). Aspartame consumption was not associated with alterations on blood glucose levels compared to control (−0.03 mmol/L; 95% CI, −0.21 to 0.14) or to sucrose (0.31 mmol/L; 95% CI, −0.05 to 0.67) and on insulin levels compared to control (0.13 μU/mL; 95% CI, −0.69 to 0.95) or to sucrose (2.54 μU/mL; 95% CI, −6.29 to 11.37). Total cholesterol was not affected by aspartame consumption compared to control (−0.02 mmol/L; 95% CI, −0.31 to 0.27) or to sucrose (−0.24 mmol/L; 95% CI, −0.89 to 0.42). Triglycerides concentrations were not affected by aspartame consumption compared to control (0.00 mmol/L; 95% CI, −0.04 to 0.05) or to sucrose (0.00 mmol/L; 95% CI, −0.09 to 0.09). High-density lipoprotein cholesterol serum levels were higher on aspartame compared to control (−0.03 mmol/L; 95% CI, −0.06 to −0.01) and lower on aspartame compared to sucrose (0.05 mmol/L; 95% CI, 0.02 to 0.09). Body weight did not change after aspartame consumption compared to control (5.00 Kg; 95% CI, −1.56 to 11.56) or to sucrose (3.78 Kg; 95% CI, −2.18 to 9.74). Energy intake was not altered by aspartame consumption compared to control (−0.49 MJ; 95% CI, −1.21 to 0.22) or to sucrose (−0.17 MJ; 95% CI, −2.03 to 1.69). <b>Conclusions</b>: Data concerning effects of aspartame on main metabolic variables associated to diabetes and obesity do not support a beneficial related to its consumption.
DOI: 10.6084/m9.figshare.4834664
title: Differential Susceptibility Manuscript_RawData_FigShare.docx.xlsx

description: Raw data for publication entitled:Trade-offs in disease and bleaching susceptibility among two color morphs of the Hawaiian reef coral, <i>Montipora capitata</i><br><i><br></i>Authors:Shore-Maggio, A; Callahan, S; Aeby, G
DOI: 10.6084/m9.figshare.4834646
title: Flutter valv.xlsx

description: Flutter on cardiac valves was studied. An analytical methodology was created to evaluate the critical speed of fluid for the onset of flutter. Also an experimental test was made to evaluate the critical speed on a test bench using a high speed camera on various flows. Dimensioness analysis was done to compare the results.<br>
DOI: 10.6084/m9.figshare.4834664.v1
title: Differential Susceptibility Manuscript_RawData_FigShare.docx.xlsx

description: Raw data for publication entitled:Trade-offs in disease and bleaching susceptibility among two color morphs of the Hawaiian reef coral, <i>Montipora capitata</i><br><i><br></i>Authors:Shore-Maggio, A; Callahan, S; Aeby, G
DOI: 10.6084/m9.figshare.4834643
title: Using dual-sex calls improves the playback census method for a nocturnal burrow-nesting seabird, the Manx Shearwater <i>Puffinus puffinus</i>

description: <b>Capsule:</b> Playback with dual-sex calls increases the response rate of Manx Shearwaters <i>Puffinus puffinus</i> by 40–60% and reduces its daily variability, which would improve the precision of population estimates. <b>Aims:</b> To test whether playing male and female calls would elicit more responses to playback than male-only calls, reduce daily variability and the length of response rate calibration trials, and give more precise estimates. We also measured response times to playback and assessed the reliability of visual signs of occupancy at burrow entrances. <b>Methods:</b> Responses to four playback call-types (male-only and three variants of dual-sex calls) were compared in repeated trials at two colonies (Ramsey and Rum, UK) during May–June 2014. <b>Results:</b> Dual-sex calls gave higher response rates with lower variance than male-only calls, because females frequently replied to female calls but rarely to male calls. In simulated 3–5-day calibration trials, response rates and correction factors were up to 50% more precise with dual-sex calls. Visual signs of burrow occupancy were unreliable. <b>Conclusion:</b> Playback for Manx Shearwaters should use a 25 seconds recording of male and female calls intermixed, with 10 seconds listening time for delayed responses. Census-specific calibration trials are essential for accurate estimates of daily response rates.
DOI: 10.6084/m9.figshare.4834646.v1
title: Flutter valv.xlsx

description: Flutter on cardiac valves was studied. An analytical methodology was created to evaluate the critical speed of fluid for the onset of flutter. Also an experimental test was made to evaluate the critical speed on a test bench using a high speed camera on various flows. Dimensioness analysis was done to compare the results.<br>
DOI: 10.6084/m9.figshare.4834640
title: nSTAT data.zip

description: This is a zip file containing the example data for nSTAT matlab toolbox (http://doi.org/10.1016/j.jneumeth.2012.08.009) . The data directory should be un-zipped into the main nSTAT directory. Updated 7-2-2017
DOI: 10.6084/m9.figshare.4834643.v2
title: Using dual-sex calls improves the playback census method for a nocturnal burrow-nesting seabird, the Manx Shearwater <i>Puffinus puffinus</i>

description: <b>Capsule:</b> Playback with dual-sex calls increases the response rate of Manx Shearwaters <i>Puffinus puffinus</i> by 40–60% and reduces its daily variability, which would improve the precision of population estimates. <b>Aims:</b> To test whether playing male and female calls would elicit more responses to playback than male-only calls, reduce daily variability and the length of response rate calibration trials, and give more precise estimates. We also measured response times to playback and assessed the reliability of visual signs of occupancy at burrow entrances. <b>Methods:</b> Responses to four playback call-types (male-only and three variants of dual-sex calls) were compared in repeated trials at two colonies (Ramsey and Rum, UK) during May–June 2014. <b>Results:</b> Dual-sex calls gave higher response rates with lower variance than male-only calls, because females frequently replied to female calls but rarely to male calls. In simulated 3–5-day calibration trials, response rates and correction factors were up to 50% more precise with dual-sex calls. Visual signs of burrow occupancy were unreliable. <b>Conclusion:</b> Playback for Manx Shearwaters should use a 25 seconds recording of male and female calls intermixed, with 10 seconds listening time for delayed responses. Census-specific calibration trials are essential for accurate estimates of daily response rates.
DOI: 10.6084/m9.figshare.4834529
title: Supplementary Table 6

description: Summary Statistics for Differential Digital Genomic Footprint Calling. This includes the total number of differential DGF, and the number of DE DGF in DE genes. Fileset also includes Rscript and linux command line instructions how to generate the data.
DOI: 10.6084/m9.figshare.4834535
title: The daily dynamic potential accessibility by car in London on Wednesdays

description: The map presented in this paper shows the effect of congestion on daily accessibility in the London metropolitan area on Wednesdays. Because of its dynamic nature, it is challenging to both calculate the effects of this phenomenon and to represent it clearly on simple maps. Although we can use many traditional techniques for this purpose, they are usually static, and they may lose some essential information on the effects studied. In this paper, we used two cartographic techniques rarely used in accessibility studies – cartograms and 3D maps, which we believe can achieve a more striking representation in static and animations of both the traffic-induced spatial distortion and the accessibility levels obtained. The results are presented in two animated maps and some snapshots of them – static maps. Both types of maps reinforce each other: Together, they can properly show the direct space–time link between congestion and accessibility, and can, therefore, give a more detailed overview of the consequences of this phenomenon.