cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.30652394.v1
title: <b>Ciprofloxacin-induced metabolic disruption and stringent response drives persistent small-colony variants in </b><b><i>Staphylococcus aureus</i></b>

description: Antibiotic treatment failure in <i>Staphylococcus aureus</i> infections is frequently associated with antimicrobial resistance or the emergence of small-colony variants (SCVs), a metabolically quiescent phenotype that complicates infection management.Here, we show that ciprofloxacin induces a stable SCV phenotype in <i>S. aureus</i>, characterized by reduced colony size, impaired growth, attenuated virulence, and prolonged persistence. Integrated genomic, transcriptomic, and metabolomic analyses revealed that ciprofloxacin-induced SCVs harbor a<i> tal</i> (transaldolase) mutation, which disrupts glycolytic and pentose phosphate pathway flux, depleting pyruvate and tricarboxylic acid cycle intermediates and collapsing ATP biosynthesis. This metabolic disruption leads to nutrient stress and energy limitation,further compounded by a <i>relA</i> mutation that elevates (p)ppGpp accumulation and activates the stringent response.The combined effects of <i>tal</i>- and <i>relA</i>-mediated reprogramming drive metabolic quiescence and the SCV state. Notably, ciprofloxacin-induced SCVs exhibited collateral sensitivity to aminoglycosides both <i>in vitro</i> and <i>in vivo</i>, suggesting that metabolic trade-offs accompanying the stringent response could be therapeutically exploited.These findings define how ciprofloxacin-induced metabolic disruption and stringent response activation cooperatively drive persistent SCV formation in <i>S. aureus</i>, providing new opportunities to overcome antibiotic persistence.
DOI: 10.5517/ccdc.csd.ccyrst8
title: CCDC 886811: Experimental Crystal Structure Determination

description: Related Article: Qiaoru Liu, Yujie Peng, Juanjuan Liu, Lingwei Xue, Ganqing Zhao|2014|Henan Shifan Daxue Xuebao (Ziran Kexue Ban)|42|74|doi:10.16366/j.cnki.1000-2367.2014.04.028
description: Related Article: Qin-Long Peng, Xiao-Ming Hu, Ling-Wei Xue|2015|Huaxue Shiji|37|574|doi:10.13822/j.cnki.hxsj.2015.06.025
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccwz0rl
title: CCDC 833210: Experimental Crystal Structure Determination

description: Related Article: Deepanjali Pandey, Shahid S. Narvi, Gopal K. Mehrotra, Raymond J. Butcher|2015|Jiegou Huaxue|34|777|doi:10.14102/j.cnki.0254-5861.2011-0259
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc10fdmg
title: CCDC 936405: Experimental Crystal Structure Determination

description: Related Article: Ji-guo Lu, Yan-ping Huo, Xiao-ming Fang, Bao-hua Huang, Kun Zhang|2014|Fenxi Ceshi Xuebao|33|993-9|doi:10.3969/j.issn.1004-4957.2014.09.003
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc110pg6
title: CCDC 953977: Experimental Crystal Structure Determination

description: Related Article: Chao Liu, Xin Zhuo, Hu Zhang, Xinhua Liu|2014|Gaodeng Xuexiao Huaxue Xuebao|35|928|doi:10.7503/cjcu.20131290
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc117bf1
title: CCDC 960362: Experimental Crystal Structure Determination

description: Related Article: Yuan Wang, Lei-Lei Wang, Yong-Qiang Xue, Xue-Ping Wang, Zi-Xiang Cui|2014|Hecheng Huaxue|35|907|doi:10.3969/j.issn.1005-1511.2014.01.008
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc117bk5
title: CCDC 960366: Experimental Crystal Structure Determination

description: Related Article: Yuan Wang, Lei-Lei Wang, Yong-Qiang Xue, Xue-Ping Wang, Zi-Xiang Cui|2014|Hecheng Huaxue|35|907|doi:10.3969/j.issn.1005-1511.2014.01.008
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc11ffhd
title: CCDC 966223: Experimental Crystal Structure Determination

description: Related Article: Wei Wang, Lian-Jie Zhai, Huan Huo, Ya-nan Li, Hui Li, Xiang-Zhi Li, Bo-Zhou Wang|2015|Huaxue Shiji|37|200|doi:10.13822/j.cnki.hxsj.2015.03.002
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc11m3yq
title: CCDC 971693: Experimental Crystal Structure Determination

description: Related Article: Christoph Rosorius, Constantin G. Daniliuc, Roland Frohlich, Gerald Kehr|2013|J.Organomet.Chem.|744|149|doi:10.1016/j.organchem.2013.06.005
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc11m3zr
title: CCDC 971694: Experimental Crystal Structure Determination

description: Related Article: Christoph Rosorius, Constantin G. Daniliuc, Roland Frohlich, Gerald Kehr|2013|J.Organomet.Chem.|744|149|doi:10.1016/j.organchem.2013.06.005
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc11m40t
title: CCDC 971695: Experimental Crystal Structure Determination

description: Related Article: Christoph Rosorius, Constantin G. Daniliuc, Roland Frohlich, Gerald Kehr|2013|J.Organomet.Chem.|744|149|doi:10.1016/j.organchem.2013.06.005
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc11m41v
title: CCDC 971696: Experimental Crystal Structure Determination

description: Related Article: Christoph Rosorius, Constantin G. Daniliuc, Roland Frohlich, Gerald Kehr|2013|J.Organomet.Chem.|744|149|doi:10.1016/j.organchem.2013.06.005
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc120p0s
title: CCDC 983754: Experimental Crystal Structure Determination

description: Related Article: Huan-Mei Guo, Jie Song, Yu-Feng Li, Pu-Su Zhao|2014|Huaxue Shiji|36|862|doi:10.13822/j.cnki.hxsj.2014.09.025
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc122fbx
title: CCDC 985438: Experimental Crystal Structure Determination

description: Related Article: Lin-Shan Bai, Ying Zhou, Qi-Yan Wang, Zhu-Qin Li, Sheng Ding, Ju-Jun Ding|2014|Huaxue Shiji|36|1125|doi:10.13822/j.cnki.hxsj.2014.12.019
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc1337dv
title: CCDC 1016006: Experimental Crystal Structure Determination

description: Related Article: Wen Lu, Shi-Long Yang, Li Xu, Yuan-Yuan Xu, Xing-Wei Chi|2016|Huaxue Shiji|8|716|doi:10.13822/j.cnki.hxsj.2016.08.003
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/cc13s1mk
title: CCDC 1036008: Experimental Crystal Structure Determination

description: Related Article: Zhi-Hong Li, Wen-Jing Guo, Zheng-Xiang Xie, Yong-Tao Wang, Qiao-Hua Wei|2015|Jiegou Huaxue|34|757|doi:10.14102/j.cnki.0254-5861.2011-0599
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/cc13t4vx
title: CCDC 1037069: Experimental Crystal Structure Determination

description: Related Article: Chuan-chuan He, Yue Li, Jing Zhao, Guan-cheng Xu, Su-rong Sun|2015|Jiegou Huaxue|34|1019|doi:10.14102/j.cnki.0254-5861.2011-0648
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc13qxmc
title: CCDC 1034923: Experimental Crystal Structure Determination

description: Related Article: Olga Kovalchukova, Sergey Aldoshin, Andrey Utenyshev, Konstantin Bogenko, Valeriy Tkachev|2015|Commun.Inorg.Synth.|3|23|doi:10.21060/cis.2015.321
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc13vvf7
title: CCDC 1038699: Experimental Crystal Structure Determination

description: Related Article: Mohammad Shoaib, Syed Wadood Ali Shah, Mehreen Ghias, Niaz Ali, Naveed Umar, Ismail Shah, Shafiullah, Muhammad Nisar, Tour Jan, Muhammad Nawaz Tahir|2020|Pak. J. Pharm. Sci|33|11|doi:10.36721/pjps.2020.33.1.reg.011-020.1
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc13vvg8
title: CCDC 1038700: Experimental Crystal Structure Determination

description: Related Article: Mohammad Shoaib, Syed Wadood Ali Shah, Mehreen Ghias, Niaz Ali, Naveed Umar, Ismail Shah, Shafiullah, Muhammad Nisar, Tour Jan, Muhammad Nawaz Tahir|2020|Pak. J. Pharm. Sci|33|11|doi:10.36721/pjps.2020.33.1.reg.011-020.1
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc13vvh9
title: CCDC 1038701: Experimental Crystal Structure Determination

description: Related Article: Mohammad Shoaib, Syed Wadood Ali Shah, Mehreen Ghias, Niaz Ali, Naveed Umar, Ismail Shah, Shafiullah, Muhammad Nisar, Tour Jan, Muhammad Nawaz Tahir|2020|Pak. J. Pharm. Sci|33|11|doi:10.36721/pjps.2020.33.1.reg.011-020.1
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc14jv5p
title: CCDC 1058872: Experimental Crystal Structure Determination

description: Related Article: Chuan Hua, Xiaojian Yang, Xingli Liu, Peihua Ma, Qingdi Zhou|2015|Huaxue Tongbao|78|1102|doi:10.14159/j.cnki.0441-3776.2015.12.007
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc14jv6q
title: CCDC 1058873: Experimental Crystal Structure Determination

description: Related Article: Chuan Hua, Xiaojian Yang, Xingli Liu, Peihua Ma, Qingdi Zhou|2015|Huaxue Tongbao|78|1102|doi:10.14159/j.cnki.0441-3776.2015.12.007
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc1j2bjg
title: CCDC 1402425: Experimental Crystal Structure Determination

description: Related Article: Fuan Li, Jianding Li, Weichun Yang|2015|Huaxue Tongbao|78|1118|doi:10.14159/j.cnki.0441-3776.2015.12.011
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc1j354y
title: CCDC 1403219: Experimental Crystal Structure Determination

description: Related Article: Xiao-Ning Wang, Yu-Fang Wang, Jun-Lei Geng, Fei-Fei Li|2016|Jiegou Huaxue|35|953|doi:10.14102/j.cnki.0254-5861.2011-0973
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/cc1j335x
title: CCDC 1403158: Experimental Crystal Structure Determination

description: Related Article: Xiao-Xun Yang, Ji-Dong Leng, Jun-Liang Liu, Jian-Hua Jia and Ming-Liang Tong|2015|Wuji Huaxue Xuebao|31|1831|doi:10.11862/CJIC.2015.260
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/cc1j336y
title: CCDC 1403159: Experimental Crystal Structure Determination

description: Related Article: Xiao-Xun Yang, Ji-Dong Leng, Jun-Liang Liu, Jian-Hua Jia and Ming-Liang Tong|2015|Wuji Huaxue Xuebao|31|1831|doi:10.11862/CJIC.2015.260
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc1j3zby
title: CCDC 1404000: Experimental Crystal Structure Determination

description: Related Article: Lun Zhao, Changjiang Zhao|2016|Gaodeng Xuexiao Huaxue Xuebao|37|1763|doi:10.7503/cjcu20160343
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/cc1j6njx
title: CCDC 1406579: Experimental Crystal Structure Determination

description: Related Article: Xiu-Yan Wang, Wei Wang, Fang-Wei Zhao|2016|Jiegou Huaxue|35|392|doi:10.14102/j.cnki.0254-5861.2011-0849
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/cc1j7p1h
title: CCDC 1407556: Experimental Crystal Structure Determination

description: Related Article: Guo-liang Zhao|2015|CSD Communication|||
description: Related Article: Yu Yuye, Yu Shigang, Zhao Guoliang|2015|Zhongguo Xitu Xuebao|33|697-6|doi:10.11785/S1000-4343.20150609
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc13h6xq
title: CCDC 1027523: Experimental Crystal Structure Determination

description: Related Article: Peter Mueller, Ashfaq Mahmood, Terrence Nicholson|2016|CSD Communication|||
description: Related Article: Terrence Nicholson, Esther Chunb, Ashfaq Mahmood, Peter Mueller, Alan Davisona and Alun G. Jones|2015|Commun.Inorg.Synth.|3|31|doi:10.21060/cis.2015.331
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc1kljm9
title: CCDC 1447781: Experimental Crystal Structure Determination

description: Related Article: Lun Zhao, Changjiang Zhao|2016|Gaodeng Xuexiao Huaxue Xuebao|37|1763|doi:10.7503/cjcu20160343
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc1lmw9d
title: CCDC 1478864: Experimental Crystal Structure Determination

description: Related Article: Jing-Min Shi|2016|CSD Communication|||
description: Related Article: Lu-Yi Zheng, Cheng-Cheng Zhang, Chi-Feng Wang, Yan-Hui Chi, Xue-Xue Chen, Jing-Min Shi, Xiao-Ping Qian, Jun Xu|2017|Jiegou Huaxue|36|1878|doi:10.14102/j.cnki.0254-5861.2011-1605
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc1lmwbf
title: CCDC 1478865: Experimental Crystal Structure Determination

description: Related Article: Jing-Min Shi|2016|CSD Communication|||
description: Related Article: Lu-Yi Zheng, Cheng-Cheng Zhang, Chi-Feng Wang, Yan-Hui Chi, Xue-Xue Chen, Jing-Min Shi, Xiao-Ping Qian, Jun Xu|2017|Jiegou Huaxue|36|1878|doi:10.14102/j.cnki.0254-5861.2011-1605
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc1mqjsn
title: CCDC 1511212: Experimental Crystal Structure Determination

description: Related Article: Yong-Lan Feng, Fu-Xing Zhang, Jiang-Xi Yu, Wu-Jiu Jiang, Dai-Zhi Kuang|2018|Wuji Huaxue Xuebao|34|1857|doi:10.11862/CJIC.2018.216
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.