cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.8480654.v1
title: Effect of a novel designed intensive patient care program on cognitive impairment, anxiety, depression as well as relapse free survival in acute ischemic stroke patients: a randomized controlled study

description: <b>Objective</b>: We aimed to evaluate the influence of a novel designed intensive patient care program (IPCP) on cognitive impairment, anxiety, depression and relapse-free survival (RFS) in acute ischemic stroke (AIS) patients. <b>Methods</b>: Two hundred forty-two AIS patients were consecutively recruited in this randomized controlled study and randomly allocated to IPCP group or control group as 1:1 ratio. Patients received IPCP and conventional treatment in IPCP group, while received usual education, cognitive rehabilitation training and conventional treatment in control group for 12-month intervention. Cognitive impairment, anxiety and depression were assessed by Mini-Mental State Examination (MMSE), Hospital Anxiety and Depression Scale (HADS) anxiety (HADS-A), and HADS depression (HADS-D) at baseline (M0), month (M)3, M6 and M12. After intervention, patients were followed up until 2018/7/30 and RFS was calculated. <b>Results</b>: IPCP increased MMSE score at M12 and change of MMSE score (M12-M0), while decreased cognitive impairment rate at M12. For anxiety, decreased change of HADS-A score (M12-M0) and lower anxiety rate at M12 were observed in IPCP group compared to control group. For depression, decreased HADS-D score at M6 and M12, reduced change of HADS-D score (M12-M0) and lower depression rate at M12 were shown in IPCP group compared to control group. Besides, RFS was numerically longer in IPCP group compared to control group, but without statistical significance. <b>Conclusions</b>: IPCP presents with a positive influence on improving cognitive impairment and decreasing anxiety as well as depression, while a less effect on improving RFS in AIS patients. <b>Abbreviation:</b> IPCP: intensive patient care program; RFS: relapse free survival; AIS: acute ischemic stroke; MRA: magnetic resonance angiography; ITT: intention-to-treat; LOCF: last observation carried forward
DOI: 10.6084/m9.figshare.20014979.v1
title: Associação entre vitamina D sérica e rinossinusite crônica: uma metanálise

description: Resumo Introdução: A rinossinusite crônica é uma inflamação crônica altamente heterogênea do trato respiratório superior causada por uma disfunção imune nos seres humanos. Entretanto, a etiologia subjacente dessa doença ainda não foi bem estabelecida. Diversos estudos revelaram que anormalidades nos níveis séricos de vitamina D podem desempenhar um papel na fisiopatologia da doença. Objetivo: Fazer uma metanálise de estudos para comparar os níveis séricos de vitamina D entre pacientes com rinossinusite crônica e controles saudáveis e avaliar as potenciais associações do nível sérico de vitamina D com a ocorrência da doença. Método: Seguindo as diretrizes Prisma, bancos de dados relevantes, inclusive Pubmed, Web of Science, Embase e Cochrane Library, foram pesquisados desde a sua data de início até 1° de dezembro de 2018. A simetria do gráfico de funil (funnel plot symmetry) e o teste de Egger foram usados para detectar o viés da publicação. Os desfechos foram apresentados como diferença média ponderada e combinamos a diferença média ponderada e intervalos de confiança de 95% para estimar a diferença dos níveis séricos de vitamina D entre pacientes com rinossinusite crônica e os controles. O valor de I2 de Higgins foi usado para testar a heterogeneidade entre os estudos incluídos. Resultados: Dos 176 estudos que identificamos, apenas oito, que envolveram 337 pacientes com rinossinusite crônica e 179 controles saudáveis, preencheram os critérios e foram incluídos na metanálise. Em uma análise combinada de todos os estudos, a diminuição do nível sérico de vitamina D foi demonstrada na rinossinusite crônica (DMP = −7,80, IC95% −13,28 ± −2,31, p = 0,000). Análises de subgrupos com base no local do estudo (EUA vs. Não EUA), tipos de biomarcadores (25[OH]D3 vs. 25[OH]D) e desenho do estudo (retrospectivo vs. prospectivo) não explicaram a heterogeneidade. No entanto, o fenótipo da rinossinusite crônica (rinossinusite crônica com pólipos nasais vs. rinossinusite crônica sem pólipos nasais) pode explicar algum grau de heterogeneidade. Contudo, um nível sérico mais baixo de vitamina D foi observado em pacientes com rinossinusite crônica com pólipos nasais. Conclusão: Nossos achados indicam que o nível sérico de vitamina D pode estar associado à rinossinusite crônica, pois detectamos uma associação significante entre níveis séricos mais baixos de vitamina D em pacientes com rinossinusite crônica, especialmente na rinossinusite crônica com pólipos nasais. No entanto, mais estudos abrangentes são necessários para se chegar a conclusões abalizadas.
DOI: 10.6084/m9.figshare.7956392
title: Additional file 2: of Marker genes as predictors of shared genomic function

description: Table S2. Summary of 16S rRNA copy statistics for each bacterial genome. Included is the number of 16S rRNA copies, the minimum and maximum length among copies, the average length of copies, and the minimum and maximum percent identity among copies. (XLSX 93 kb)
DOI: 10.6084/m9.figshare.20015007.v1
title: Prevalence of middle ear disease in Chilean natives and the impact of development over 14 years

description: Abstract Introduction The prevalence of middle ear disease and its risk factors have been the subject of multiple studies. High prevalence of middle ear disease has been described among North American natives, especially chronic otitis media. Such studies have not been carried out in South America. Objective To describe the prevalence of middle ear pathology and risk factors in native schoolchildren from southern Chile who belong to the Mapuche ethnic group, as well as the impact of socio-economic and demographic changes after 14 years of development. Material and methods Two otologic evaluations with an interval of 14 years were performed in schoolchildren with a percentage of indigenous population above 85%. Socioeconomic and demographic data were collected from national official statistical data. Results A total of 1067 schoolchildren were examined. Many described risk factors for ear pathology were found. An overall prevalence of 0.19% for tympanic membrane perforation, 5.6% for pars tensa retraction pockets, 1.5% for pars flaccida retraction pockets and 11.1% of otitis media with effusion was found. There were several socioeconomic improvements after 14 years. The difference between the prevalence of symptoms and the presence of otitis media with effusion was statistically significant (p &lt; 0.001). Conclusions Despite the presence of several risk factors for middle ear disease, this study population showed a low prevalence of middle ear disease. The ethnic-racial factor seems to be a protective factor.
DOI: 10.6084/m9.figshare.7956392.v1
title: Additional file 2: of Marker genes as predictors of shared genomic function

description: Table S2. Summary of 16S rRNA copy statistics for each bacterial genome. Included is the number of 16S rRNA copies, the minimum and maximum length among copies, the average length of copies, and the minimum and maximum percent identity among copies. (XLSX 93 kb)
DOI: 10.6084/m9.figshare.20014905
title: The efficacy and safety of ciclesonide for the treatment of perennial allergic rhinitis: a systematic review and meta-analysis

description: Abstract Introduction: Allergic rhinitis is a chronic inflammatory disease which affects 1 out of 6 individuals. Perennial allergic rhinitis accounts for 40% of AR cases. Ciclesonide is one of the relatively new intranasal steroid for allergic rhinitis. Objective: The purpose of this study was to evaluate the efficacy and safety of ciclesonide in the treatment of perennial allergic rhinitis. Methods: We searched Pubmed, Scientific Citation Index, Embase, Clinical Trial Registries for randomized controlled trials and Cochrane Central Register of Controlled Trials to find out the randomized controlled Trial comparing ciclesonide with placebo for PAR. Results: Eight studies were included. In comparison with placebo groups, ciclesonide groups significantly decreased Reflective Total Nasal Symptom Score (MD = −0.56; 95% CI −0.72 to 0.39, p &lt; 0.00001) with heterogeneity (p = 0.19, I2 = 24%), Instantaneous Total Nasal Symptom Score (MD = −0.57; 95% CI −0.75 to −0.39, p &lt; 0.00001) with heterogeneity (p = 0.34, I2 = 11%). A significant effect for Reflective Nasal Symptom Score Subtotal (MD = −0.15; 95% CI −0.18 to −0.13, p &lt; 0.00001) with heterogeneity (p = 0.12, I2 = 24%) was also demonstrated. Rhinoconjunctivitis quality of life questionnaire score (RQLQs) (MD = −0.27; 95% CI −0.39 to −0.15, p &lt; 0.00001) with heterogeneity (p = 0.58, I 2 = 0%) in the treatment of ciclesonide was also significantly reduced. In addition, the difference in Treatment-Emergent Adverse Events between the two groups was not significant. Conclusion: Ciclesonide can improve perennial allergic rhinitis without increasing adverse events. Ciclesonide may be another valuable choice for perennial allergic rhinitis in the future.
DOI: 10.6084/m9.figshare.20014905.v1
title: The efficacy and safety of ciclesonide for the treatment of perennial allergic rhinitis: a systematic review and meta-analysis

description: Abstract Introduction: Allergic rhinitis is a chronic inflammatory disease which affects 1 out of 6 individuals. Perennial allergic rhinitis accounts for 40% of AR cases. Ciclesonide is one of the relatively new intranasal steroid for allergic rhinitis. Objective: The purpose of this study was to evaluate the efficacy and safety of ciclesonide in the treatment of perennial allergic rhinitis. Methods: We searched Pubmed, Scientific Citation Index, Embase, Clinical Trial Registries for randomized controlled trials and Cochrane Central Register of Controlled Trials to find out the randomized controlled Trial comparing ciclesonide with placebo for PAR. Results: Eight studies were included. In comparison with placebo groups, ciclesonide groups significantly decreased Reflective Total Nasal Symptom Score (MD = −0.56; 95% CI −0.72 to 0.39, p &lt; 0.00001) with heterogeneity (p = 0.19, I2 = 24%), Instantaneous Total Nasal Symptom Score (MD = −0.57; 95% CI −0.75 to −0.39, p &lt; 0.00001) with heterogeneity (p = 0.34, I2 = 11%). A significant effect for Reflective Nasal Symptom Score Subtotal (MD = −0.15; 95% CI −0.18 to −0.13, p &lt; 0.00001) with heterogeneity (p = 0.12, I2 = 24%) was also demonstrated. Rhinoconjunctivitis quality of life questionnaire score (RQLQs) (MD = −0.27; 95% CI −0.39 to −0.15, p &lt; 0.00001) with heterogeneity (p = 0.58, I 2 = 0%) in the treatment of ciclesonide was also significantly reduced. In addition, the difference in Treatment-Emergent Adverse Events between the two groups was not significant. Conclusion: Ciclesonide can improve perennial allergic rhinitis without increasing adverse events. Ciclesonide may be another valuable choice for perennial allergic rhinitis in the future.
DOI: 10.6084/m9.figshare.20015076
title: Repair of large traumatic tympanic membrane perforation using ofloxacin otic solution and gelatin sponge

description: Abstract Introduction Traumatic large tympanic membrane perforations usually fail to heal and require longer healing times. Few studies have compared the healing and hearing outcomes between gelatin sponge patching and ofloxacin otic solution. Objectives To compare the healing outcomes of large traumatic tympanic membrane perforations treated with gelatin sponge, ofloxacin otic solution, and spontaneous healing. Methods Traumatic tympanic membrane perforations &gt;50% of the entire eardrum were randomly divided into three groups: ofloxacin otic solution, gelatin sponge patch and spontaneous healing groups. The healing outcome and hearing gain were compared between the three groups at 6 months. Results A total of 136 patients with large traumatic tympanic membrane perforations were included in analyses. The closure rates were 97.6% (40/41), 87.2% (41/47), and 79.2% (38/48) in the ofloxacin otic solution, gelatin sponge patch, and spontaneous healing groups, respectively (p = 0.041). The mean times to closure were 13.12 ± 4.61, 16.47 ± 6.24, and 49.51 ± 18.22 days in these groups, respectively (p &lt; 0.001). Conclusions Gelatin sponge patch and ofloxacin otic solution may serve as effective and inexpensive treatment strategies for traumatic large tympanic membrane perforations. However, ofloxacin otic solution must be self-applied daily to keep the perforation edge moist, while gelatin sponge patching requires periodic removal and re-patching.
DOI: 10.6084/m9.figshare.7956398
title: Additional file 3: of Marker genes as predictors of shared genomic function

description: Table S3. A list showing the ratio of shared genes for each bacterial genome comparison. Data is included for each of the three datasets; Full-length 16S rRNA, V4 16S rRNA, and MLSA. (XLSX 1048 kb)
DOI: 10.6084/m9.figshare.7956353.v1
title: Additional file 1: of HIV-1 Tat enhances purinergic P2Y4 receptor signaling to mediate inflammatory cytokine production and neuronal damage via PI3K/Akt and ERK MAPK pathways

description: Figure S1. Distribution of GFP in CNS of mice infected by lentivirus. The lentivirus suspension of LV-sh-P2Y4R was injected into mice through the tail vein for 14 days, and then mice were sacrificed and frozen sections (15 μm) from brain tissues. GFP expression was detected under fluorescence microscope (n = 3, original amplification, × 40). Table S1. The list of primer sequences for qPCR assay. (ZIP 263 kb)
DOI: 10.6084/m9.figshare.20015007
title: Prevalence of middle ear disease in Chilean natives and the impact of development over 14 years

description: Abstract Introduction The prevalence of middle ear disease and its risk factors have been the subject of multiple studies. High prevalence of middle ear disease has been described among North American natives, especially chronic otitis media. Such studies have not been carried out in South America. Objective To describe the prevalence of middle ear pathology and risk factors in native schoolchildren from southern Chile who belong to the Mapuche ethnic group, as well as the impact of socio-economic and demographic changes after 14 years of development. Material and methods Two otologic evaluations with an interval of 14 years were performed in schoolchildren with a percentage of indigenous population above 85%. Socioeconomic and demographic data were collected from national official statistical data. Results A total of 1067 schoolchildren were examined. Many described risk factors for ear pathology were found. An overall prevalence of 0.19% for tympanic membrane perforation, 5.6% for pars tensa retraction pockets, 1.5% for pars flaccida retraction pockets and 11.1% of otitis media with effusion was found. There were several socioeconomic improvements after 14 years. The difference between the prevalence of symptoms and the presence of otitis media with effusion was statistically significant (p &lt; 0.001). Conclusions Despite the presence of several risk factors for middle ear disease, this study population showed a low prevalence of middle ear disease. The ethnic-racial factor seems to be a protective factor.
DOI: 10.6084/m9.figshare.7956353
title: Additional file 1: of HIV-1 Tat enhances purinergic P2Y4 receptor signaling to mediate inflammatory cytokine production and neuronal damage via PI3K/Akt and ERK MAPK pathways

description: Figure S1. Distribution of GFP in CNS of mice infected by lentivirus. The lentivirus suspension of LV-sh-P2Y4R was injected into mice through the tail vein for 14 days, and then mice were sacrificed and frozen sections (15 μm) from brain tissues. GFP expression was detected under fluorescence microscope (n = 3, original amplification, × 40). Table S1. The list of primer sequences for qPCR assay. (ZIP 263 kb)
DOI: 10.6084/m9.figshare.7956506.v1
title: Additional file 1: of Elucidating the transcriptional program of feline injection-site sarcoma using a cross-species mRNA-sequencing approach

description: Table S1. Sample information for the FISS transcriptome profiling. Each row corresponds to an RNA sample. Columns are as follows: sample name, the coded sample name used within this manuscript; biosample type, indicates whether the sample came from primary tissue or cultured cells; normal or cancer, distinguishes whether the sample is normal or cancerous; tissue type, gives the tissue subtype, such as sarcoma, skin, or muscle; Cat, the coded cat patient ID for this study; batch, the mRNA-seq batch number (see Methods); “#reads”, the total number of reads derived from the sample; “#uniquely mapped reads”, the number of reads that mapped to a unique location in the cat genome; %alignment, the percentage of the total number of reads that aligned to a unique location in the cat genome; #genes with non-zero count, the number of genes for which the count of aligned reads is greater than zero. (XLSX 11 kb)
DOI: 10.6084/m9.figshare.20015102.v1
title: Management of refractory cervical anastomotic fistula after esophagectomy using the pectoralis major myocutaneous flap

description: Abstract Introduction A refractory cervical anastomotic fistula which postoperatively remains unhealed for more than 2 months under conservative care severely impacts the quality of life of the patient and potentially leads to anastomotic stricture after the fistula heals. It is widely accepted that, to avoid this complication, refractory cervical anastomotic fistulas should undergo more aggressive treatments. However, when and which surgical intervention should be considered is unclear. Objective This study was designed to evaluate the role of the pectoralis major myocutaneous flap in the management of refractory cervical anastomotic fistulas based on our experience of 6 cases and a literature review. Methods Six patients diagnosed with refractory cervical anastomotic fistula after esophagectomy treated using pectoralis major myocutaneous flap transfer were included in the study. The clinical data, surgical details, and treatment outcome were retrospectively analyzed. Results All patients survived the operations. One patient who had a circumferential anastomotic defect resulting from surgical exploration developed a mild fistula in the neo-anastomotic site in the 5th postoperative day, which healed after 7 days of conservative care. This patient developed an anastomotic stricture which was partially alleviated by an endoscopic anastomotic dilatation. All the other 5 patients had uneventful recoveries after operations and restored oral intake on the 10th-15th days after operation, and they tolerated normal diets without subsequent sequelae on follow-up. One patient developed both local and lung recurrence and died in 15 months after operation, while the other 5 patients survived with good tumor control during the follow-up of 25-53 months. Conclusion The satisfactory treatment outcome in our study demonstrates that pectoralis major myocutaneous flap reconstruction is a reliable management modality for refractory cervical anastomotic fistulas after esophagectomy, particularly for those patients who experienced persistent fistulas after conservative wound care and repeated wound closures.
DOI: 10.6084/m9.figshare.7956506
title: Additional file 1: of Elucidating the transcriptional program of feline injection-site sarcoma using a cross-species mRNA-sequencing approach

description: Table S1. Sample information for the FISS transcriptome profiling. Each row corresponds to an RNA sample. Columns are as follows: sample name, the coded sample name used within this manuscript; biosample type, indicates whether the sample came from primary tissue or cultured cells; normal or cancer, distinguishes whether the sample is normal or cancerous; tissue type, gives the tissue subtype, such as sarcoma, skin, or muscle; Cat, the coded cat patient ID for this study; batch, the mRNA-seq batch number (see Methods); “#reads”, the total number of reads derived from the sample; “#uniquely mapped reads”, the number of reads that mapped to a unique location in the cat genome; %alignment, the percentage of the total number of reads that aligned to a unique location in the cat genome; #genes with non-zero count, the number of genes for which the count of aligned reads is greater than zero. (XLSX 11 kb)
DOI: 10.6084/m9.figshare.7956416
title: Additional file 5: of Marker genes as predictors of shared genomic function

description: Table S5. The table provides details of all significantly shared and unshared GO terms for bacterial genomes whose V4 16S rRNA sequences clustered at greater than 99% identity. (XLSX 158 kb)
DOI: 10.6084/m9.figshare.7956407
title: Additional file 4: of Marker genes as predictors of shared genomic function

description: Table S4. Summary of BLAST results comparing the unshared gene content of bacterial genomes whose V4 16s rRNA clustered at 99% identity. (XLSX 23 kb)
DOI: 10.6084/m9.figshare.7956521.v1
title: Additional file 3: of Elucidating the transcriptional program of feline injection-site sarcoma using a cross-species mRNA-sequencing approach

description: Table S2. Differentially expressed genes in FISS. mRNA-seq gene expression data for 21,890 cat genes in all feline tissue and cell culture samples in this study. Columns as follows: Geneid, Ensembl identifier for the gene; Chrom, identifier of the cat chromosome (MT, mitochondrial chromosome; chromosome identifiers starting with “JH” are unplaced scaffolds) to which the gene has been mapped; Gene Start, leftmost chromosomal coordinate of the gene in the genome assembly; Gene End, rightmost chromosomal coordinate of the gene; Strand, the direction of transcription of the gene (1 denotes positive strand, − 1 denotes negative strand); Symbol, official gene symbol; Description, gene description field; Columns 8–21, absolute RNA-seq tag counts within the indicated gene (row), in the indicated sample (column); log2_fold_change_tissue, log2(sarcoma/skin) value (or “NA” if not statistically significantly different from zero); p_adj_tissue, adjusted p-value for expression level comparison between the sarcoma and skin sample groups; log2_fold_change_cultured_cells, log2(sarcoma cell / fibroblast) value (or NA if not detected as nonzero with statistical significance); p_adj_cultured_cells, adjusted p-value for expression-level comparison between the sarcoma cell line and fibroblast sample groups. (XLSX 4618 kb)
DOI: 10.25549/usctheses-ouc11257936
title: MergedFile
DOI: 10.25549/usctheses-ouc11257940
title: 00001.tif
DOI: 10.25549/usctheses-ouc11257949
title: Microsoft Word - BurciagaDisseration 1-26-2017.docx
DOI: 10.6084/m9.figshare.12144081.v1
title: Additional file 1 of Genome-wide analysis of the citrus B3 superfamily and their association with somatic embryogenesis

description: Additional file 1 B3 genes identified in the genomes of sweet orange (Citrus sinensis) and pummelo (C. grandis).
DOI: 10.25549/usctheses-c18-654573
title: The Shtetl In The Novels Of Isaac Bashevis Singer
DOI: 10.6084/m9.figshare.12144081
title: Additional file 1 of Genome-wide analysis of the citrus B3 superfamily and their association with somatic embryogenesis

description: Additional file 1 B3 genes identified in the genomes of sweet orange (Citrus sinensis) and pummelo (C. grandis).
DOI: 10.6084/m9.figshare.12144087.v1
title: Additional file 2 of Genome-wide analysis of the citrus B3 superfamily and their association with somatic embryogenesis

description: Additional file 2 Ka/Ks calculation of the duplicated B3 gene pairs in sweet orange (Citrus sinensis) and pummelo (C. grandis).