cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.30498425
title: Supplementary Material for: Extensive Brainstem Lesion and Cervical Myelopathy: Overcoming a Grim Prognosis - Case Report

description: Introduction: 
Cognard-type V arteriovenous fistulas are rare forms of dural arteriovenous malformations. This specific subtype is characterised by spinal venous drainage into peri-medullary veins, which presents as progressive or ascending myelopathy in 50% of cases. 
Case Presentation: A 59-year-old man with three weeks of worsening quadriparesis, along with abnormal sensory findings, gait deterioration, and bowel and bladder dysfunction, was admitted to the hospital. MRI revealed extensive T2 hyperintense signal changes in the brainstem and myelopathy in the cervical spinal cord extending down to C7. The differential diagnosis for extensive myelopathy and brainstem lesions seen on MRI included a tumour, autoimmune inflammation, and suspicion of vascular malformation. The administration of corticosteroids resulted in a worsening of the patient’s neurological symptoms. Conventional angiography confirmed the presence of a dural AVF (a small arteriovenous short shunt receiving arterial supply from the middle meningeal and occipital artery) in the territory of the left external carotid artery. A minimally invasive endovascular treatment was successfully performed. 
Conclusion: 
We present this case considering that only 100 patients with Cognard type V fistula have been reported to date. Additionally, we aim to highlight the importance of caution when administering corticosteroids in cases of diagnostic uncertainty.
DOI: 10.6084/m9.figshare.30498425.v1
title: Supplementary Material for: Extensive Brainstem Lesion and Cervical Myelopathy: Overcoming a Grim Prognosis - Case Report

description: Introduction: 
Cognard-type V arteriovenous fistulas are rare forms of dural arteriovenous malformations. This specific subtype is characterised by spinal venous drainage into peri-medullary veins, which presents as progressive or ascending myelopathy in 50% of cases. 
Case Presentation: A 59-year-old man with three weeks of worsening quadriparesis, along with abnormal sensory findings, gait deterioration, and bowel and bladder dysfunction, was admitted to the hospital. MRI revealed extensive T2 hyperintense signal changes in the brainstem and myelopathy in the cervical spinal cord extending down to C7. The differential diagnosis for extensive myelopathy and brainstem lesions seen on MRI included a tumour, autoimmune inflammation, and suspicion of vascular malformation. The administration of corticosteroids resulted in a worsening of the patient’s neurological symptoms. Conventional angiography confirmed the presence of a dural AVF (a small arteriovenous short shunt receiving arterial supply from the middle meningeal and occipital artery) in the territory of the left external carotid artery. A minimally invasive endovascular treatment was successfully performed. 
Conclusion: 
We present this case considering that only 100 patients with Cognard type V fistula have been reported to date. Additionally, we aim to highlight the importance of caution when administering corticosteroids in cases of diagnostic uncertainty.
DOI: 10.15468/dl.z24pss
title: Occurrence Download

description: A dataset containing 1531 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is one of (Acomys dimidiatus, Acomys minous)"
 ]
}

 The dataset includes 1531 records from 31 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0009383-251025141854904/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.6084/m9.figshare.30498428
title: Supplementary Material for: The association of age, sex, and educational attainment on verbal associative memory performance among Hispanic individuals with differing first spoken language

description: Introduction: Hispanics are the fastest growing segment of the elderly population in the United States. An assessment of their English and Spanish language dominance is important to consider for cognitive aging. In this manuscript we utilized an internet-based study (MindCrowd, MC) to recruit Hispanic participants from within the United States who differ on their first language and examined the influence of the known three most significant associated factors – age, sex, and educational attainment – on their verbal memory performance. 

Methods: We utilized participants who joined MC after the launch of the updated site in June of 2022. Participants were included if they self-reported their age between 18-90, their biological sex as either male or female, and their maximum educational attainment, and completed the entire 10-minute MC cognitive testing experience which includes an assessment of verbal associative memory (PAL, paired-associates learning). Additionally, we included only those individuals who participated in English; however, the Hispanic cohort was split into two groups depending on their self-reported first spoken language (FSL) as either English or Spanish. Propensity matching was also used to create a cohort whose FSL was Spanish and who matched the demographics of the FSL English Hispanic cohort. Regression statistics were used to calculate significance and estimate effect sizes. 

Results: Age, biological sex, and educational attainment are all significantly associated with PAL performance in both Hispanic cohorts regardless of the participant’s FSL. Compared to non-Hispanic MC participants, age had a more negative influence on PAL performance in Hispanics while the association of educational attainment was similar across both Hispanic groups and Non-Hispanics. Interestingly, FSL Spanish Hispanics demonstrated a less negative association of biological sex on PAL performance. In contrast to FSL English Hispanics and Non-Hispanics, where females outperformed males on PAL performance, no difference between males and females was observed among FSL Spanish Hispanics. This finding was replicated in a MC sub-cohort of propensity matched FSL Spanish Hispanics. 

Conclusions: The three known factors associated with verbal memory performance (age, sex, and educational attainment) are also significantly associated in Hispanic individuals, including those who spoke English or Spanish as their FSL. However, the strength of several factors differed substantially across groups, including age and sex. The study highlights the importance of considering factors predicting cognitive aging outcomes in large, well-characterized, but separate demographic groups.
DOI: 10.6084/m9.figshare.30498428.v1
title: Supplementary Material for: The association of age, sex, and educational attainment on verbal associative memory performance among Hispanic individuals with differing first spoken language

description: Introduction: Hispanics are the fastest growing segment of the elderly population in the United States. An assessment of their English and Spanish language dominance is important to consider for cognitive aging. In this manuscript we utilized an internet-based study (MindCrowd, MC) to recruit Hispanic participants from within the United States who differ on their first language and examined the influence of the known three most significant associated factors – age, sex, and educational attainment – on their verbal memory performance. 

Methods: We utilized participants who joined MC after the launch of the updated site in June of 2022. Participants were included if they self-reported their age between 18-90, their biological sex as either male or female, and their maximum educational attainment, and completed the entire 10-minute MC cognitive testing experience which includes an assessment of verbal associative memory (PAL, paired-associates learning). Additionally, we included only those individuals who participated in English; however, the Hispanic cohort was split into two groups depending on their self-reported first spoken language (FSL) as either English or Spanish. Propensity matching was also used to create a cohort whose FSL was Spanish and who matched the demographics of the FSL English Hispanic cohort. Regression statistics were used to calculate significance and estimate effect sizes. 

Results: Age, biological sex, and educational attainment are all significantly associated with PAL performance in both Hispanic cohorts regardless of the participant’s FSL. Compared to non-Hispanic MC participants, age had a more negative influence on PAL performance in Hispanics while the association of educational attainment was similar across both Hispanic groups and Non-Hispanics. Interestingly, FSL Spanish Hispanics demonstrated a less negative association of biological sex on PAL performance. In contrast to FSL English Hispanics and Non-Hispanics, where females outperformed males on PAL performance, no difference between males and females was observed among FSL Spanish Hispanics. This finding was replicated in a MC sub-cohort of propensity matched FSL Spanish Hispanics. 

Conclusions: The three known factors associated with verbal memory performance (age, sex, and educational attainment) are also significantly associated in Hispanic individuals, including those who spoke English or Spanish as their FSL. However, the strength of several factors differed substantially across groups, including age and sex. The study highlights the importance of considering factors predicting cognitive aging outcomes in large, well-characterized, but separate demographic groups.
DOI: 10.6084/m9.figshare.30498431
title: Supplementary Material for: Genetic Syndromes Including Intellectual Disability and Different Cancer Types

description: Background: The aim of this study is to determine genetic syndromes including both cancers and intellectual disabilities, specific cancer types accompanying intellectual disabilities.
Summary: We obtained the data from the clinical synopsis of the syndromes available in the OMIM database (https://www.omim.org/). In the first step, we detected 794 syndromes using different terms of intellectual disabilities and cancers. In the second step, we investigated the clinical synopsis of each syndrome in detail. Of these, we included 99 syndromes in which both intellectual disability and any type of cancer were presented. In the third step, we collected following data of these 99 syndromes: OMIM number, gene and location, syndrome/protein, tumor/neoplasia, inheritance, growth, head/neck, respiratory, cardiovascular, abdomen, genitourinary, skeletal, skin/nails/hair, neurologic, endocrine features, immunology, prenatal manifestations, laboratory abnormalities and other system findings.

Key Messages: The most common cancer types among these 99 syndromes are listed in percentage. Since individuals with intellectual disabilities have difficulty expressing themselves and understanding the symptoms of the disease, the diagnosis of diseases in these people is late and their treatment becomes difficult. We suggest that genetic tests to be performed in intellectual disability are important for early diagnosis, follow-up and treatment of accompanying cancers. We especially emphasize the importance of leukemia, brain tumors and tumors of embryonal origin in individuals with intellectual disability.
DOI: 10.6075/j06m363g
title: CIL:254, Mus musculus, skeletal muscle cell. In Cell Image Library

description: Preparation: glutaraldehyde fixed tissue; osmium tetroxide fixed tissue
Relation to intact cell: microtome-sectioned tissue
Item type: recorded image
Imaging mode: transmission electron microscopy (TEM)
Parameter imaged: electron density
Source of contrast: uranyl salt; lead salt
Visualization methods: detection of electrons
Processing history: unprocessed raw data
description: Thin section electron microscopy of diaphragm (skeletal) muscle from a wild type mouse.

Sample was viewed with a Hitachi 7600 electron microscope (accelerating voltage 80 KV) and imaged with an AMT digital camera. Image taken at 30,000X magnification.

This image is part of a set of wild type diaphragm muscle images that served as controls for the study of the delta-sarcoglycan knockout mouse. Both the set of wild-type and delta-sarcoglycan knockout mouse images are part of The CELL: an image library.

Reference: Nat Med. 2008 Apr;14(4):442-7. 
Genetic and pharmacologic inhibition of mitochondrial-dependent necrosis attenuates muscular dystrophy.
Millay DP, Sargent MA, Osinska H, Baines CP, Barton ER, Vuagniaux G, Sweeney HL, Robbins J, Molkentin JD (tissue preparation described in Fewell JG, et al. A treadmill exercise regimen for identifying cardiovascular phenotypes in transgenic mice. Am J Physiol. 1997;273:H1595–H1605)
DOI: 10.6084/m9.figshare.30498431.v1
title: Supplementary Material for: Genetic Syndromes Including Intellectual Disability and Different Cancer Types

description: Background: The aim of this study is to determine genetic syndromes including both cancers and intellectual disabilities, specific cancer types accompanying intellectual disabilities.
Summary: We obtained the data from the clinical synopsis of the syndromes available in the OMIM database (https://www.omim.org/). In the first step, we detected 794 syndromes using different terms of intellectual disabilities and cancers. In the second step, we investigated the clinical synopsis of each syndrome in detail. Of these, we included 99 syndromes in which both intellectual disability and any type of cancer were presented. In the third step, we collected following data of these 99 syndromes: OMIM number, gene and location, syndrome/protein, tumor/neoplasia, inheritance, growth, head/neck, respiratory, cardiovascular, abdomen, genitourinary, skeletal, skin/nails/hair, neurologic, endocrine features, immunology, prenatal manifestations, laboratory abnormalities and other system findings.

Key Messages: The most common cancer types among these 99 syndromes are listed in percentage. Since individuals with intellectual disabilities have difficulty expressing themselves and understanding the symptoms of the disease, the diagnosis of diseases in these people is late and their treatment becomes difficult. We suggest that genetic tests to be performed in intellectual disability are important for early diagnosis, follow-up and treatment of accompanying cancers. We especially emphasize the importance of leukemia, brain tumors and tumors of embryonal origin in individuals with intellectual disability.
DOI: 10.6075/j06d5rr9
title: CIL:25383, Maize mosaic virus, Peregrinus maidis, peripheral neuron. In Cell Image Library

description: Aggregates of Maize mosaic virus (MMV, Rhabdoviridae) in nerves of the insect vector Peregrinus maidis (planthopper, Hemiptera, Delphacidae). Antibodies to MMV identify aggregates (green/yellow fluorescence). Nuclei are stained red. 

Dissected insect organs were fixed in paraformaldehyde, labeled with primary antibodies to MMV, and with secondary antibodies: Alexa Fluor-488 (green), and later stained with the nuclear stain propidium iodide (red). Whole mounts were examined with confocal laser- scanning microscope (Leica TCS SP).

Associated references: 
Ammar, E.-D. and S. A. Hogenhout, S.A. (2008). A neurotropic route for Maize mosaic virus (Rhabdoviridae) in its planthopper vector Peregrinus maidis. Virus Research 131: 77-85.
Ammar, E.-D. and Nault, L.R. (1985). Assembly and accumulation sites of Maize mosaic virus in its planthopper vector. Intervirology 24: 33-41.
description: Preparation: formaldehyde fixed tissue; permeabilized tissue
Relation to intact cell: whole mounted tissue
Item type: recorded image
Imaging mode: confocal microscopy
Parameter imaged: fluorescence emission
Source of contrast: differences in adsorption or binding of stain; distribution of epitope
Visualization methods: primary antibody plus labeled secondary antibody; Alexa Fluor 488; propidium iodide
Processing history: recorded image
Data qualification: Processed
DOI: 10.6084/m9.figshare.30498434
title: Supplementary Material for: Assessing the Impact of Health Research in Saudi Arabia: A Cross-Sectional Survey of Researchers’ Perceptions of Importance and Implementation Barriers

description: Background
Engaging researchers early in the process of research assessment increases transparency and builds a sense of ownership, which ensures successful implementation and sustainability and fosters a healthier research culture. In anticipation of the potential implementation of research impact assessment in Saudi Arabia, the aim of this study is to explore the views of health care researchers regarding i) the perceived importance of different categories and indicators used to track health research impacts, ii) the purposes of research impact assessment and iii) the barriers associated with implementing research impact assessment.
Methods
 A web-based cross-sectional survey was conducted between June 8 and September 20, 2023. Academic and nonacademic researchers (n=110) working in Saudi Arabia completed the questionnaire. The categories and indicators used to capture the diverse ways in which research impacts arise were drawn from the Payback Framework and the Canadian Academy of Health Sciences framework. We used descriptive statistics to report demographic characteristics and perceptions and t tests or ANOVA to examine the impact of respondent characteristics on their ratings of the importance of impact indicators. The data were analyzed using IBM SPSS 30.
Results
Among the 110 respondents, 91 (82.7%) supported the move toward research impact assessment. Among the indicators used to track research impact, publications in peer-reviewed journals and contributions to better health outcomes were assigned the highest level of importance. The most commonly selected purpose for impact assessment was to allocate funds to projects that are more likely to benefit society and the economy (n=85, 77%). The most commonly reported barrier to assessment implementation was the extensive resources needed to collect data (68%), followed by researchers’ perception that existing research is not driven by the health needs of the Saudi community (66.4%).
Conclusions
Our findings suggest that, in general, Saudi researchers support a move toward impact assessment, but they have clear preferences for the indicators measured to capture impact and for the purpose of impact assessment. Strategies to counter the expected barriers to impact assessment, such as those suggested in our paper, need to be explored and addressed by decision-makers planning for impact assessment in the Saudi context.
DOI: 10.6084/m9.figshare.30498434.v1
title: Supplementary Material for: Assessing the Impact of Health Research in Saudi Arabia: A Cross-Sectional Survey of Researchers’ Perceptions of Importance and Implementation Barriers

description: Background
Engaging researchers early in the process of research assessment increases transparency and builds a sense of ownership, which ensures successful implementation and sustainability and fosters a healthier research culture. In anticipation of the potential implementation of research impact assessment in Saudi Arabia, the aim of this study is to explore the views of health care researchers regarding i) the perceived importance of different categories and indicators used to track health research impacts, ii) the purposes of research impact assessment and iii) the barriers associated with implementing research impact assessment.
Methods
 A web-based cross-sectional survey was conducted between June 8 and September 20, 2023. Academic and nonacademic researchers (n=110) working in Saudi Arabia completed the questionnaire. The categories and indicators used to capture the diverse ways in which research impacts arise were drawn from the Payback Framework and the Canadian Academy of Health Sciences framework. We used descriptive statistics to report demographic characteristics and perceptions and t tests or ANOVA to examine the impact of respondent characteristics on their ratings of the importance of impact indicators. The data were analyzed using IBM SPSS 30.
Results
Among the 110 respondents, 91 (82.7%) supported the move toward research impact assessment. Among the indicators used to track research impact, publications in peer-reviewed journals and contributions to better health outcomes were assigned the highest level of importance. The most commonly selected purpose for impact assessment was to allocate funds to projects that are more likely to benefit society and the economy (n=85, 77%). The most commonly reported barrier to assessment implementation was the extensive resources needed to collect data (68%), followed by researchers’ perception that existing research is not driven by the health needs of the Saudi community (66.4%).
Conclusions
Our findings suggest that, in general, Saudi researchers support a move toward impact assessment, but they have clear preferences for the indicators measured to capture impact and for the purpose of impact assessment. Strategies to counter the expected barriers to impact assessment, such as those suggested in our paper, need to be explored and addressed by decision-makers planning for impact assessment in the Saudi context.
DOI: 10.6075/j06d5rvn
title: CIL:25379, Maize mosaic virus, Peregrinus maidis. In Cell Image Library

description: Preparation: formaldehyde fixed tissue; permeabilized tissue
Relation to intact cell: whole mounted tissue
Item type: recorded image
Imaging mode: confocal microscopy
Parameter imaged: fluorescence emission
Source of contrast: differences in adsorption or binding of stain; distribution of epitope
Visualization methods: primary antibody plus labeled secondary antibody; Alexa Fluor 488; propidium iodide
Processing history: recorded image
Data qualification: Processed;spatialmeasurements
description: Aggregates of maize mosaic virus (MMV, Rhabdoviridae) in cells of the anterior diverticulum of the insect vector Peregrinus maidis (planthopper, Hemiptera, Delphacidae). Antibodies to MMV identify aggregates (green/yellow fluorescence) that accumulate mainly around the nuclei (red) in cells of the anterior diverticulum. Accompanying image in this image group is unlabeled. 

Methods: Dissected insect organs were fixed in paraformaldehyde, labeled with primary antibodies to MMV, and with secondary antibodies: Alexa Fluor-488 (green), and later stained with the nuclear stain propidium iodide (red). Whole mounts were examined with confocal laser- scanning microscope (Leica TCS SP).

Associated references: 
Ammar, E.-D. and S. A. Hogenhout, S.A. (2008). A neurotropic route for Maize mosaic virus (Rhabdoviridae) in its planthopper vector Peregrinus maidis. Virus Research 131: 77-85.
Ammar, E.-D. and Nault, L.R. (1985). Assembly and accumulation sites of Maize mosaic virus in its planthopper vector. Intervirology 24: 33-41.