cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.4047273
title: Supplementary Material for: Neurosurgical Treatments for Patients with Chronic, Treatment-Refractory Depression: A Retrospective, Consecutive, Case Series Comparison of Anterior Capsulotomy, Anterior Cingulotomy and Vagus Nerve Stimulation

description: <br><strong><em>Background:</em></strong> The evidence base to guide therapeutic choices for patients with chronic and treatment-refractory depression (TRD) remains weak. There is limited comparative information available to guide the choice of intervention for patients with the most severe and disabling forms of illness. <b><i>Objectives:</i></b> The aim of this work was to describe the 12-month clinical outcomes of patients with chronic TRD treated with anterior capsulotomy (ACAPS; n = 5), anterior cingulotomy (ACING; n = 5) or vagus nerve stimulation (VNS; n = 5). <b><i>Methods:</i></b> We performed a retrospective, consecutive, case series comparison. <b><i>Results:</i></b> With clinical response defined as a ≥50% reduction from the baseline MADRS score, response rates were 40% for ACAPS, 60% for ACING and 20% for VNS. Adverse effects from all three procedures were relatively mild, consistent with previous reports and, in most cases, transient. Adverse effects from VNS were related to active stimulation, and were modifiable and diminished in severity over time. There were no deaths. <b><i>Conclusions:</i></b> Although based on a small sample, our data represent a unique comparison of ACAPS, ACING and VNS for chronic TRD. The three cohorts were broadly equivalent in terms of baseline clinical characteristics, indices of chronicity, illness severity and estimates of previous failed treatments. ACING and ACAPS, but not VNS, were associated with favourable response rates at 12 months.
DOI: 10.7910/dvn/v1rjpf/w6y7vj
title: blc20160219_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.4047273.v1
title: Supplementary Material for: Neurosurgical Treatments for Patients with Chronic, Treatment-Refractory Depression: A Retrospective, Consecutive, Case Series Comparison of Anterior Capsulotomy, Anterior Cingulotomy and Vagus Nerve Stimulation

description: <br><strong><em>Background:</em></strong> The evidence base to guide therapeutic choices for patients with chronic and treatment-refractory depression (TRD) remains weak. There is limited comparative information available to guide the choice of intervention for patients with the most severe and disabling forms of illness. <b><i>Objectives:</i></b> The aim of this work was to describe the 12-month clinical outcomes of patients with chronic TRD treated with anterior capsulotomy (ACAPS; n = 5), anterior cingulotomy (ACING; n = 5) or vagus nerve stimulation (VNS; n = 5). <b><i>Methods:</i></b> We performed a retrospective, consecutive, case series comparison. <b><i>Results:</i></b> With clinical response defined as a ≥50% reduction from the baseline MADRS score, response rates were 40% for ACAPS, 60% for ACING and 20% for VNS. Adverse effects from all three procedures were relatively mild, consistent with previous reports and, in most cases, transient. Adverse effects from VNS were related to active stimulation, and were modifiable and diminished in severity over time. There were no deaths. <b><i>Conclusions:</i></b> Although based on a small sample, our data represent a unique comparison of ACAPS, ACING and VNS for chronic TRD. The three cohorts were broadly equivalent in terms of baseline clinical characteristics, indices of chronicity, illness severity and estimates of previous failed treatments. ACING and ACAPS, but not VNS, were associated with favourable response rates at 12 months.
DOI: 10.6084/m9.figshare.4047267
title: Supplementary Material for: Determinants and Prognostic Significance of Hematoma Sedimentation Levels in Acute Intracerebral Hemorrhage

description: <strong><em>Background:</em></strong> This study aimed at identifying the determinants and prognostic significance of a sedimentation level (fluid-blood level) in the hematoma among patients with acute intracerebral hemorrhage (ICH) who participated in the main Intensive Blood Pressure Reduction in Acute Cerebral Hemorrhage Trial (INTERACT2). <b><i>Methods:</i></b> Post-hoc analysis of the INTERACT2 dataset, a randomized controlled trial of patients with acute ICH with elevated systolic blood pressure (SBP), randomly assigned to intensive (target SBP &lt;140 mm Hg) or guideline-based (&lt;180 mm Hg) BP management. Patients with a sedimentation level at baseline assessment on CT, and modified Rankin Scale score at 90-day, were included in these analyses. Factors associated with a sedimentation level and its significance in relation to 90-day clinical outcomes were assessed in univariable and multivariable logistic regression models. <b><i>Results:</i></b> Of 2,065 participants, 19 (1%) had sedimentation level on baseline CT, which was independently associated with warfarin use (p = 0.006) and lobar ICH (p = 0.025). Sedimentation level was also associated with death or major disability at 90-day in both crude (84 vs. 53%; p = 0.014) and multivariable analyses adjusted for age, gender, Chinese region, warfarin use, baseline National Institutes of Health Stroke Scale score, onset to CT time, volume and location of ICH, intraventricular extension, and randomized intensive BP lowering (OR 3.94, 95% CI 1.01-15.37; p = 0.049). <b><i>Conclusions:</i></b> The presence of hematoma sedimentation level on baseline CT is associated with warfarin use and lobar location of ICH, and predicts a worse outcome. Although uncommon, sedimentation level is an easily detectable prognostic factor in acute ICH.<br>
DOI: 10.7910/dvn/v1rjpf/l3tsvi
title: blc20160426_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.4047264
title: Supplementary Material for: Utility of Prediction Scores for Hepatocellular Carcinoma in Patients with Chronic Hepatitis B Treated with Nucleos(t)ide Analogues

description: <strong><em>Objective:</em></strong> The utility of risk scores to predict the development of hepatocellular carcinoma (HCC) in chronic hepatitis B (CHB) patients treated with nucleos(t)ide analogue (NA) remains to be elucidated. <b><i>Methods:</i></b> CU-HCC (The Chinese University of Hong Kong-HCC) and GAG-HCC (Guide with Age, Gender, HBV DNA, Core promoter mutations and Cirrhosis) scores of 225 Japanese patients treated with NAs for at least 2 years were calculated before and 2 years after the NA treatment. According to the cutoff values, the patients were categorized into high-score or low-score groups. <b><i>Results:</i></b> Sixteen of 225 patients developed HCC. Patients with a high score before the NA treatment showed a significantly higher HCC incidence than those with a low score using both score models (p &lt; 0.001). Time-dependent receiver operating characteristic analyses based on scores before and 2 years after the NA treatment showed that both models exhibited moderate accuracy in predicting HCC development. The HCC incidence was significantly lower in the patients whose scores decreased below the cutoff values in response to the NA treatment than in those whose scores remained high using both models (p &lt; 0.01). <b><i>Conclusions:</i></b> The predictive performance of the CU-HCC and GAG-HCC scores in the CHB patients treated with NAs is comparable to that in the NA-naive patients. The patients with sustained high scores after the NA treatment showed a higher incidence of HCC development.<br>
DOI: 10.6084/m9.figshare.4047264.v1
title: Supplementary Material for: Utility of Prediction Scores for Hepatocellular Carcinoma in Patients with Chronic Hepatitis B Treated with Nucleos(t)ide Analogues

description: <strong><em>Objective:</em></strong> The utility of risk scores to predict the development of hepatocellular carcinoma (HCC) in chronic hepatitis B (CHB) patients treated with nucleos(t)ide analogue (NA) remains to be elucidated. <b><i>Methods:</i></b> CU-HCC (The Chinese University of Hong Kong-HCC) and GAG-HCC (Guide with Age, Gender, HBV DNA, Core promoter mutations and Cirrhosis) scores of 225 Japanese patients treated with NAs for at least 2 years were calculated before and 2 years after the NA treatment. According to the cutoff values, the patients were categorized into high-score or low-score groups. <b><i>Results:</i></b> Sixteen of 225 patients developed HCC. Patients with a high score before the NA treatment showed a significantly higher HCC incidence than those with a low score using both score models (p &lt; 0.001). Time-dependent receiver operating characteristic analyses based on scores before and 2 years after the NA treatment showed that both models exhibited moderate accuracy in predicting HCC development. The HCC incidence was significantly lower in the patients whose scores decreased below the cutoff values in response to the NA treatment than in those whose scores remained high using both models (p &lt; 0.01). <b><i>Conclusions:</i></b> The predictive performance of the CU-HCC and GAG-HCC scores in the CHB patients treated with NAs is comparable to that in the NA-naive patients. The patients with sustained high scores after the NA treatment showed a higher incidence of HCC development.<br>
DOI: 10.7910/dvn/v1rjpf/yoayty
title: blc20160722_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.4047252
title: Bench-scale microbial remediation of the model acid mine drainage: effects of nutrients and microbes on the source bioremediation

description: <br>In this work, a bench-scale microbial remediation system was established by supplemented nutrients, sulfate reducing bacteria and iron reducing bacteria to inhibit key factors (iron oxidizing bacteria and oxidation reduction potential) during the formation of acid mine drainage. The results indicated sodium lactate could inhibit the growth of <i>A. ferrooxidans</i> and their ability of oxidizing ferrous ion, could alleviate but not prevent the pyrite oxidizing process. Organic nutrients prevented pyrite oxidation effectively by the adjustment of microbial community. Sulfate reducing bacteria adapted to the remediate environment and improved physicochemical index of group 1. Sulfate reducing bacteria and nutrients are the key factor for bioremediation.
DOI: 10.7910/dvn/v1rjpf/nzibnf
title: blc20160901_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/p3jgtq
title: blc20160721_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/r3ikcp
title: blc20160604_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/ibkqhq
title: blc20160104_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.4047231
title: End-stage renal disease adherence questionnaire: translation and validation to the portuguese language

description: Non-adherence to medical plans is recognized as an important problem in dialysis patients, since it has been associated with increased morbidity and mortality, resulting in disproportionately high costs of care. The success of renal replacement therapy depends on the adherence of patients to the different aspects of the therapeutic strategy, which includes a complex drug regimen involving a wide variety of drugs and doses, several prescribed dialysis sessions with different durations, dietetic recommendations and restriction of fluid intake. In this work, we aimed to translate and validate a previously described self-reported end-stage renal disease questionnaire (ESRD-AQ) to the Portuguese language (PESRD-AQ). After ESRD-AQ translation, a validation was performed by experts and by using a cohort of 185 Portuguese dialysis patients. PESRD-AQ reliability analysis showed strong test–retest stability across all items, with an intra-class correlation of 0.931. The average of the item-level content validity index by experts for the 46 items was 0.98, ranging from 0.94 to 1. Moreover, we found that PESRD-AQ scores indicative of non-adherence were associated with alterations in some biological and biochemical markers of non-adherence, including interdialytic weight gain. In conclusion, our results showed that PESRD-AQ, which presented an acceptable reliability and validity, is a valid tool to be used for adherence evaluation by Portuguese-speaking dialysis patients.
DOI: 10.7910/dvn/v1rjpf/hiztob
title: blc20160826_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.4047231.v1
title: End-stage renal disease adherence questionnaire: translation and validation to the portuguese language

description: Non-adherence to medical plans is recognized as an important problem in dialysis patients, since it has been associated with increased morbidity and mortality, resulting in disproportionately high costs of care. The success of renal replacement therapy depends on the adherence of patients to the different aspects of the therapeutic strategy, which includes a complex drug regimen involving a wide variety of drugs and doses, several prescribed dialysis sessions with different durations, dietetic recommendations and restriction of fluid intake. In this work, we aimed to translate and validate a previously described self-reported end-stage renal disease questionnaire (ESRD-AQ) to the Portuguese language (PESRD-AQ). After ESRD-AQ translation, a validation was performed by experts and by using a cohort of 185 Portuguese dialysis patients. PESRD-AQ reliability analysis showed strong test–retest stability across all items, with an intra-class correlation of 0.931. The average of the item-level content validity index by experts for the 46 items was 0.98, ranging from 0.94 to 1. Moreover, we found that PESRD-AQ scores indicative of non-adherence were associated with alterations in some biological and biochemical markers of non-adherence, including interdialytic weight gain. In conclusion, our results showed that PESRD-AQ, which presented an acceptable reliability and validity, is a valid tool to be used for adherence evaluation by Portuguese-speaking dialysis patients.
DOI: 10.7910/dvn/v1rjpf/2tbenz
title: blc20161217_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/vei6g0
title: blc20160312_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/sstjbx
title: blc20160302_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.4047006
title: Combination of microbubbles and diagnostic ultrasound at a high mechanical index for the synergistic microwave ablation of tumours

description: <b>Objectives:</b> To determine whether combining microbubbles (MBs) with diagnostic ultrasound (US) at a high mechanical index (MI) could enhance the microwave (MW) ablation of tumours. <b>Materials and methods:</b> Five therapeutic MW adjuvant protocols were studied: MW, MW + US, MW + US + MB, MW + US + NS (saline) and MW + MB. In 30 normal rabbit livers, the synergistic effects were evaluated via temperature, necrosis volume and histology. In 90 VX2 rabbit hepatic tumours, residual cells in the peripheral ablated tumours were examined via immunohistochemical assay and tumour growth. Additional 40 VX2 hepatic tumours were evaluated for ablation safety via blood assay and weight and for survival to 105 days. Results were compared using analysis of variance. <b>Results:</b> Compared with the other protocols, the ablation volumes in normal rabbit livers were significantly larger using the MW + US + MB protocol (<i>p</i> p p p p <b>Conclusions:</b> MBs in combination with diagnostic US at a high MI showed potential synergy in the MW ablation of tumours in rabbits.
DOI: 10.7910/dvn/v1rjpf/rzaocr
title: blc20161115_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.4047006.v2
title: Combination of microbubbles and diagnostic ultrasound at a high mechanical index for the synergistic microwave ablation of tumours

description: <b>Objectives:</b> To determine whether combining microbubbles (MBs) with diagnostic ultrasound (US) at a high mechanical index (MI) could enhance the microwave (MW) ablation of tumours. <b>Materials and methods:</b> Five therapeutic MW adjuvant protocols were studied: MW, MW + US, MW + US + MB, MW + US + NS (saline) and MW + MB. In 30 normal rabbit livers, the synergistic effects were evaluated via temperature, necrosis volume and histology. In 90 VX2 rabbit hepatic tumours, residual cells in the peripheral ablated tumours were examined via immunohistochemical assay and tumour growth. Additional 40 VX2 hepatic tumours were evaluated for ablation safety via blood assay and weight and for survival to 105 days. Results were compared using analysis of variance. <b>Results:</b> Compared with the other protocols, the ablation volumes in normal rabbit livers were significantly larger using the MW + US + MB protocol (<i>p</i> p p p p <b>Conclusions:</b> MBs in combination with diagnostic US at a high MI showed potential synergy in the MW ablation of tumours in rabbits.
DOI: 10.7910/dvn/v1rjpf/4vxarv
title: blc20161201_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/iixsm2
title: blc20161118_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/qr814y
title: blc20160728_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/jdcttv
title: blc20160223_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/swmaan
title: blc20161021_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/vgeg9l
title: blc20160410_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/zwskbw
title: blc20160623_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/iileuz
title: blc20160726_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/7msafv
title: blc20160327_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/wihiso
title: blc20160820_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/3gqsxp
title: blc20161102_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.4046907
title: Sharpe et al. 2016.xlsx

description: Original data for the publication "Lead (Pb) Isotope Baselines for Studies of Ancient Human Migration and Trade in the Maya Region" (PLOS ONE, 2016). Data include results of 60 rock samples analyzed for lead isotope ratios and a representative subset of samples for lead, uranium, and thorium concentrations across the Maya region, including the Northern Lowlands of the Mexican Yucatan Peninsula, the Southern Lowlands of Guatemala and Belize, the Volcanic Highlands, the Belizean Maya Mountains, and the Metamorphic Province/Motagua Valley. Tab labels correspond to the table numbers in the text. Tables 1-4 are identical to those in the text, except that the lead and strontium isotope values include all digits after the decimal. Research methodology and techniques are detailed in the publication text. <br>Table 1: Lead and strontium results from the Mesoamerican samples used in this study. 87Sr/86Sr isotope ratios, with the exception of the samples from Ceibal, were previously reported in Gilli A, Hodell DA, Kamenov GD, Brenner M. Geological and archaeological implications of strontium isotope analysis of exposed bedrock in the Chicxulub crater basin, northwestern Yucatán, Mexico. Geol. 2009; 37: 723-726 and Hodell DA., Quinn RL, Brenner M, Kamenov G. Spatial variation of strontium isotopes (87Sr/86Sr) in the Maya region: A tool for tracking ancient human migration. J Archaeol Sci. 2004; 31: 585–601. Limestone ages obtained using the strontium data with the method described by McArthur JM, Howarth RJ, Bailey TR. LOWESS Version 3. Best-fit line to the marine Sr-isotope curve for 0 to 509 Ma and accompanying look-up table for deriving numerical age. Geol. 2001; 109: 155-169. The abbreviation est. denotes estimates GPS coordinates.<br>Table 2: Lead values from modern botanical and weak-acid soil leachate samples recovered from Yucatan, Mexico. <br>Table 3: Comparison of lead ratios obtained from limestone leachates with residues. The leachate represents the limestone fraction dissolved in 1N HCl. The residue was digested with concentrated HNO3 and HF. The abbreviation est. denotes estimated GPS coordinates.<br>Table 4: Lead, thorium, and uranium concentrations (ppm) in selected samples from the study area. The abbreviation est. denotes estimated GPS coordinates.<br>
DOI: 10.7910/dvn/v1rjpf/xa4hxx
title: blc20160324_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.4046907.v1
title: Sharpe et al. 2016.xlsx

description: Original data for the publication "Lead (Pb) Isotope Baselines for Studies of Ancient Human Migration and Trade in the Maya Region" (PLOS ONE, 2016). Data include results of 60 rock samples analyzed for lead isotope ratios and a representative subset of samples for lead, uranium, and thorium concentrations across the Maya region, including the Northern Lowlands of the Mexican Yucatan Peninsula, the Southern Lowlands of Guatemala and Belize, the Volcanic Highlands, the Belizean Maya Mountains, and the Metamorphic Province/Motagua Valley. Tab labels correspond to the table numbers in the text. Tables 1-4 are identical to those in the text, except that the lead and strontium isotope values include all digits after the decimal. Research methodology and techniques are detailed in the publication text. <br>Table 1: Lead and strontium results from the Mesoamerican samples used in this study. 87Sr/86Sr isotope ratios, with the exception of the samples from Ceibal, were previously reported in Gilli A, Hodell DA, Kamenov GD, Brenner M. Geological and archaeological implications of strontium isotope analysis of exposed bedrock in the Chicxulub crater basin, northwestern Yucatán, Mexico. Geol. 2009; 37: 723-726 and Hodell DA., Quinn RL, Brenner M, Kamenov G. Spatial variation of strontium isotopes (87Sr/86Sr) in the Maya region: A tool for tracking ancient human migration. J Archaeol Sci. 2004; 31: 585–601. Limestone ages obtained using the strontium data with the method described by McArthur JM, Howarth RJ, Bailey TR. LOWESS Version 3. Best-fit line to the marine Sr-isotope curve for 0 to 509 Ma and accompanying look-up table for deriving numerical age. Geol. 2001; 109: 155-169. The abbreviation est. denotes estimates GPS coordinates.<br>Table 2: Lead values from modern botanical and weak-acid soil leachate samples recovered from Yucatan, Mexico. <br>Table 3: Comparison of lead ratios obtained from limestone leachates with residues. The leachate represents the limestone fraction dissolved in 1N HCl. The residue was digested with concentrated HNO3 and HF. The abbreviation est. denotes estimated GPS coordinates.<br>Table 4: Lead, thorium, and uranium concentrations (ppm) in selected samples from the study area. The abbreviation est. denotes estimated GPS coordinates.<br>
DOI: 10.6084/m9.figshare.4046904
title: Is there a Future for Nuclear Power? Wind and Emission Reduction Targets in Fossil-Fuel Alberta

description: <br>This paper explores the viability of relying on wind power to replace upwards of 60% of electricity generation in Alberta that would be lost if coal-fired generation is phased out. Using hourly wind data from 17 locations across Alberta, we are able to simulate the potential wind power output available to the Alberta grid when modern, 3.5 MW-capacity wind turbines are spread across the province. Using wind regimes for the years 2006 through 2015, we find that available wind power is less than 60% of installed capacity 98% of the time, and below 30% of capacity 74% of the time. In addition, there is significant correlation between wind speeds at different locations, so it will always be necessary to rely on fossil fuel generation. Then, based on the results from a grid allocation model, we find that CO<sub>2</sub> emissions can be reduced by about 30%, but only through a combination of investment in wind energy and reliance on purchases of hydropower from British Columbia. Only if nuclear energy is permitted into the generation mix would Alberta be able to meet its CO<sub>2</sub>-emissions reduction target in the electricity sector. With nuclear power, emissions can be reduced by upwards of 85%.
DOI: 10.7910/dvn/v1rjpf/q8ldxi
title: blc20160407_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/k9sukg
title: blc20161202_03.txt.gz

description: :unav