cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.6176210.v1
title: Dataset for: Toxicity and Chemistry of Wastewater from Hydraulic Fracture and Conventional Shale Gas Wells

description: New technology has enabled recovery of inaccessible natural gas shale deposits, however, the human health risks from the migration of brines into drinking water or surface spills are unknown. To provide information that can inform these risks, chemical characterization and in vitro toxicologic testing was conducted using pre- and post-injection waters from conventional and unconventional oil and gas wells. In acute cytotoxicity and wound healing assays, there was dose-dependent toxicity in human and rat cells with growth promotion at low concentrations. Lethality was measured in time studies up to 10 days post-injection. Produced water samples from both well types were equally toxic to human cells and were corrosive at high concentrations. Measurement of protein and gene expression identified metabolic pathways responding to both well types as NQO1 oxidative stress-responsive enzyme and tight junction protein genes. A KCl sample of matched ionic strength showed a different toxicity profile than produced waters, indicating that salts alone were not the cause of toxicity. Organic chemicals and branched alkanes were present in hydraulic fracture wells and mainly branched alkanes were present in conventional wells. One organic substance was still present after 240 days, The known properties of these chemicals include toxicity to multiple human organs, sensitization, irritation, developmental effects and tumor promotion.
DOI: 10.6084/m9.figshare.6176174.v1
title: Supplementary Material for: Serum Obestatin: A Biomarker of Cardiovascular and All-Cause Mortality in Hemodialysis Patients

description: <b><i>Background:</i></b> Recent experimental studies have suggested that obestatin, a proposed anorexigenic gut hormone and a physiological opponent of acyl-ghrelin, has protective cardiovascular effects. We tested the hypothesis that obestatin is independent of inflammatory mediators and/or acyl-ghrelin in predicting outcomes of the maintenance hemodialysis (MHD) population. <b><i>Methods:</i></b> It was a 6-year cohort study on 261 MHD patients. Obestatin, acyl-ghrelin, adipokines (leptin and adiponectin), markers of inflammation and nutrition, prospective all-cause and cardiovascular mortality were studied. <b><i>Results:</i></b> During the follow-up, 160 patients died in total, with 74 deaths due to cardiovascular causes. For each ng/mL increase in baseline obestatin level in fully adjusted models (including malnutrition-inflammation score, Interleukin-6 [IL-6], adipokines and acyl-ghrelin), the hazard for death from all causes was 0.90 (95% CI 0.81–0.99) and for cardiovascular death 0.85 (95% CI 0.73–0.99). However, these associations were more robust in the subgroup of patients aged above 71 years: 0.85 (95% CI 0.73–0.98) for all-cause death and 0.66 (95% CI 0.52–0.85) for cardiovascular death. An interaction between high IL-6 (above median) and low obestatin (below median) levels for increased risk of all-cause mortality (synergy index [SI] 5.14, <i>p</i> = 0.001) and cardiovascular mortality (SI 4.81, <i>p</i> = 0.02) emerged in the development of multivariable adjusted models. Interactions were also observed between obestatin, Tumor necrosis factor-alpha, adipokines and acyl-ghrelin, which were associated with mortality risk. <b><i>Conclusion:</i></b> Serum obestatin behaves as a biomarker for cardiovascular and all-cause mortality in MHD patients. The prognostic ability of obestatin in this regard is independent of inflammation, nutritional status, acyl-ghrelin’s and adipokines’ activity and is modified by age being very prominent in patients older than 71 years.
DOI: 10.6084/m9.figshare.6176168
title: Dataset for: Dissipation of plant protection products from foliage

description: In the environmental risk assessment for plant protection products in the EU a foliar dissipation half life (default DT50) of 10 days is considered for the risk assessment of birds and mammals feeding on sprayed foliage. This generic DT50 of 10 days is based on a compilation of residue trials conducted over 30 years ago, in which many compounds and formulations were considered that are not used any more. We have therefore reassessed foliar dissipation based on a dataset of 396 residue trials covering 30 compounds. Foliar dissipation half lives were calculated and potential factors determining dissipation were analysed, such as crop group, residue zone or rainfall. The strongest source of variability was found between individual trials. Other factors, including the residue zone or crop groups did not have a significant impact on dissipation. Only heavy rainfall (&gt;6.5 mm/day, i.e. the 95th percentile rainfall) had a statistically significant influence, although rainfall explained only about five percent of the overall variability. Moderate rainfall (≤6.5 mm/day) did not significantly correlate with dissipation and explained only 0.1 percent of the overall variability. Most importantly, the differences in DT50 between crops and residue zones were neither marked nor statistically significant, hence trials from different residue zones and crops could be pooled to obtain more robust half lives. Over all compounds, trials, zones and crops the geometric mean DT50 was 3.2 days (90th percentile: 7.9 days).
DOI: 10.6084/m9.figshare.6176168.v1
title: Dataset for: Dissipation of plant protection products from foliage

description: In the environmental risk assessment for plant protection products in the EU a foliar dissipation half life (default DT50) of 10 days is considered for the risk assessment of birds and mammals feeding on sprayed foliage. This generic DT50 of 10 days is based on a compilation of residue trials conducted over 30 years ago, in which many compounds and formulations were considered that are not used any more. We have therefore reassessed foliar dissipation based on a dataset of 396 residue trials covering 30 compounds. Foliar dissipation half lives were calculated and potential factors determining dissipation were analysed, such as crop group, residue zone or rainfall. The strongest source of variability was found between individual trials. Other factors, including the residue zone or crop groups did not have a significant impact on dissipation. Only heavy rainfall (&gt;6.5 mm/day, i.e. the 95th percentile rainfall) had a statistically significant influence, although rainfall explained only about five percent of the overall variability. Moderate rainfall (≤6.5 mm/day) did not significantly correlate with dissipation and explained only 0.1 percent of the overall variability. Most importantly, the differences in DT50 between crops and residue zones were neither marked nor statistically significant, hence trials from different residue zones and crops could be pooled to obtain more robust half lives. Over all compounds, trials, zones and crops the geometric mean DT50 was 3.2 days (90th percentile: 7.9 days).
DOI: 10.6084/m9.figshare.6176165
title: Supplementary Material for: Hidradenitis Suppurativa Associated with Down Syndrome Is Characterized by Early Age at Diagnosis

description: <b><i>Background/Aims:</i></b> The association between hidradenitis suppurativa (HS) and multiple comorbidities has been widely investigated but data about the coexistence of Down syndrome (DS) are scarce. We sought to evaluate the prevalence of DS among a population of HS patients and assess their clinical features. <b><i>Methods:</i></b> We collected demographic and clinical data of patients affected with HS referred to three Italian outpatient dermatology clinics. <b><i>Results:</i></b> A total of 257 HS patients were enrolled, 62% females and 38% males (mean age [±SD]: 23.3 ± 10.7 years); 9 of the 257 patients (3.5%), 7 females and 2 males, had concomitant HS and DS. The patients with DS and HS had a significantly earlier age of onset (mean age: 14.3 ± 3.6 vs. 23.4 ± 12.31 years; <i>p</i> = 0.029), a significantly younger age at diagnosis (mean age: 21.1 ± 11.1 vs. 31.8 ± 13.5 years; <i>p</i> = 0.015), and were significantly younger (mean age: 23.3 ± 10.7 vs. 34.6 ± 13.07 years; <i>p</i> = 0.005). No significant differences about other clinical data were found between the two groups.<b><i> Conclusion:</i></b> The prevalence of DS in HS patients corresponds to a not negligible 3.5% of cases, who experienced an onset of HS at a younger age compared to patients with HS only.
DOI: 10.6084/m9.figshare.6176165.v1
title: Supplementary Material for: Hidradenitis Suppurativa Associated with Down Syndrome Is Characterized by Early Age at Diagnosis

description: <b><i>Background/Aims:</i></b> The association between hidradenitis suppurativa (HS) and multiple comorbidities has been widely investigated but data about the coexistence of Down syndrome (DS) are scarce. We sought to evaluate the prevalence of DS among a population of HS patients and assess their clinical features. <b><i>Methods:</i></b> We collected demographic and clinical data of patients affected with HS referred to three Italian outpatient dermatology clinics. <b><i>Results:</i></b> A total of 257 HS patients were enrolled, 62% females and 38% males (mean age [±SD]: 23.3 ± 10.7 years); 9 of the 257 patients (3.5%), 7 females and 2 males, had concomitant HS and DS. The patients with DS and HS had a significantly earlier age of onset (mean age: 14.3 ± 3.6 vs. 23.4 ± 12.31 years; <i>p</i> = 0.029), a significantly younger age at diagnosis (mean age: 21.1 ± 11.1 vs. 31.8 ± 13.5 years; <i>p</i> = 0.015), and were significantly younger (mean age: 23.3 ± 10.7 vs. 34.6 ± 13.07 years; <i>p</i> = 0.005). No significant differences about other clinical data were found between the two groups.<b><i> Conclusion:</i></b> The prevalence of DS in HS patients corresponds to a not negligible 3.5% of cases, who experienced an onset of HS at a younger age compared to patients with HS only.
DOI: 10.6084/m9.figshare.6176126
title: Dataset for: Regulation of cellular senescence via the FOXO4-p53 axis

description: Forkhead box O (FOXO) and p53 proteins are transcription factors that regulate diverse signalling pathways to control cell cycle, apoptosis and metabolism. In the last decade both FOXO and p53 have been identified as key players in aging, and their misregulation is linked to numerous diseases including cancers. However, many of the underlying molecular mechanisms remain mysterious, including regulation of ageing by FOXOs and p53. Several activities appear to be shared between FOXOs and p53, including their central role in the regulation of cellular senescence. In this review, we will focus on the recent advances on the link between FOXOs and p53, with a particular focus on the FOXO4-p53 axis and the role of FOXO4/p53 in cellular senescence. Moreover, we discuss potential strategies for targeting the FOXO4-p53 interaction to modulate cellular senescence as a drug target in treatment of aging-related diseases and morbidity.
DOI: 10.6084/m9.figshare.6176126.v1
title: Dataset for: Regulation of cellular senescence via the FOXO4-p53 axis

description: Forkhead box O (FOXO) and p53 proteins are transcription factors that regulate diverse signalling pathways to control cell cycle, apoptosis and metabolism. In the last decade both FOXO and p53 have been identified as key players in aging, and their misregulation is linked to numerous diseases including cancers. However, many of the underlying molecular mechanisms remain mysterious, including regulation of ageing by FOXOs and p53. Several activities appear to be shared between FOXOs and p53, including their central role in the regulation of cellular senescence. In this review, we will focus on the recent advances on the link between FOXOs and p53, with a particular focus on the FOXO4-p53 axis and the role of FOXO4/p53 in cellular senescence. Moreover, we discuss potential strategies for targeting the FOXO4-p53 interaction to modulate cellular senescence as a drug target in treatment of aging-related diseases and morbidity.
DOI: 10.6084/m9.figshare.6176123
title: Supplementary Material for: Imaging Care Requirements: Use of Functional Neuroimaging to Predict Dementia Caregiver Burden

description: <b><i>Background:</i></b> Dementia caregivers frequently report high stress, with increased burden associated with worse outcomes for both patients and caregivers. Although many studies relate clinical phenotypes to burden, the relationship between imaging pathology and burden, irrespective of diagnosis, is unknown. This study investigated the relationship between caregiver burden and patient regional cerebral blood flow in dementia. <b><i>Methods:</i></b> Seventy-sev en patients with cognitive impairment undergoing brain perfusion single-photon emission computed tomography imaging in normal clinical care and their caregivers were recruited. Caregiver burden was ranked from “little” to “severe” using the Zarit Burden Interview and perfusion values extracted from the patient images for predefined regions of interest. The associations between burden score and regional function on imaging were tested. <b><i>Results:</i></b> Burden score was significantly higher for caregivers of patients with abnormal perfusion compared to those with normal perfusion in the left and right frontal, right parietal, and right temporal lobes. No difference in burden was found in the left parietal or temporal groups. Correlations showed that a higher caregiver burden was associated with lower patient perfusion scores in the same regions. <b><i>Conclusion:</i></b> Caregiver burden is strongly related to the extent of frontal or right-predominant parietal or temporal lobe dysfunction. Regional abnormality on perfusion imaging can be used to facilitate identification of individuals who are likely to create a high burden on caregivers.
DOI: 10.6084/m9.figshare.6176117
title: Supplementary Material for: Driving Cessation in Patients Attending a Young-Onset Dementia Clinic: A Retrospective Cohort Study

description: <b><i>Background:</i></b> Although driving by persons with dementia is an important public health concern, little is known about driving cessation in younger people with dementia. We aimed to determine the prevalence and factors affecting driving cessation in individuals with and without dementia aged under 65 years attending a memory clinic in a European setting. <b><i>Methods:</i></b> Subjects were consecutive patients assessed at a specialist memory service at a university teaching hospital between 2000 and 2010. The data collected included demographic, clinical, standardized cognitive assessments as well as information on driving. Dementia diagnosis was made using ICD-10 criteria. <b><i>Results:</i></b> Of the 225 people who were or had been drivers, 32/79 (41%) with young-onset dementia (YOD) stopped driving compared to 25/146 (17%) patients who had cognitive impairment due to other causes. Women were more likely to cease driving and voluntarily than men (<i>p</i> &lt; 0.001). Diagnosis of YOD was associated with driving cessation (1.193, 95% CI 0.570–1.815, <i>p</i> ≤ 0.001), and was mediated by impairment in praxis with the highest indirect mediation effect (0.754, 95% CI 0.183–1.401, <i>p</i> = 0.009). <b><i>Conclusions:</i></b> YOD diagnosis, female gender, and impairment in praxis have a higher probability for driving cessation in those under 65 years of age with cognitive impairment.
DOI: 10.6084/m9.figshare.6176123.v1
title: Supplementary Material for: Imaging Care Requirements: Use of Functional Neuroimaging to Predict Dementia Caregiver Burden

description: <b><i>Background:</i></b> Dementia caregivers frequently report high stress, with increased burden associated with worse outcomes for both patients and caregivers. Although many studies relate clinical phenotypes to burden, the relationship between imaging pathology and burden, irrespective of diagnosis, is unknown. This study investigated the relationship between caregiver burden and patient regional cerebral blood flow in dementia. <b><i>Methods:</i></b> Seventy-sev en patients with cognitive impairment undergoing brain perfusion single-photon emission computed tomography imaging in normal clinical care and their caregivers were recruited. Caregiver burden was ranked from “little” to “severe” using the Zarit Burden Interview and perfusion values extracted from the patient images for predefined regions of interest. The associations between burden score and regional function on imaging were tested. <b><i>Results:</i></b> Burden score was significantly higher for caregivers of patients with abnormal perfusion compared to those with normal perfusion in the left and right frontal, right parietal, and right temporal lobes. No difference in burden was found in the left parietal or temporal groups. Correlations showed that a higher caregiver burden was associated with lower patient perfusion scores in the same regions. <b><i>Conclusion:</i></b> Caregiver burden is strongly related to the extent of frontal or right-predominant parietal or temporal lobe dysfunction. Regional abnormality on perfusion imaging can be used to facilitate identification of individuals who are likely to create a high burden on caregivers.
DOI: 10.6084/m9.figshare.6176096
title: postgresEnriched.csv

description: Results for Postgress
DOI: 10.6084/m9.figshare.6176096.v1
title: postgresEnriched.csv

description: Results for Postgress
DOI: 10.6084/m9.figshare.6176078.v1
title: Small-mammal indicators of biochronology at Cueva Negra del Estrecho del Río Quípar (Caravaca de la Cruz, Murcia, SE Spain)

description: Abundant small-mammal teeth excavated at the Palaeolithic site of Cueva Negra del Estrecho del Río Quípar have morphological and metric characteristics that are shown to correspond to <i>Iberomys huescarensis, Stenocranius gregaloides, Terricola arvalidens, Victoriamys chalinei, Mimomys savini, Pliomys episcopalis, Crictetulus (Allocricetus) bursae, Apodemus cf. sylvaticus, Eliomys quercinus, Sciurus sp.</i>, <i>Oryctolagus giberti, Lepus sp</i>., <i>Prolagus calpensis</i>, <i>Crocidura kornfeldi, Neomys sp., Sorex sp., Erinaceus cf. europaeus</i>). These taxa have been described in the late Early Pleistocene of the Iberian Peninsula. The biochronological analysis derived from the study of arvicolid remains in Cueva Negra is consistent with the reverse magnetic polarity of the entire sedimentary fill, indicating that they accumulated during the Matuyama magnetochron, between 0.99 and 0.78 Ma.
DOI: 10.6084/m9.figshare.6176072
title: Profiling the Short-lives Cationic Species Generated within Catalytic Dehydration of Short Chain Alcohols

description: Short chain alcohols are important products of biomass conversion and can be further converted into platform chemicals through heterogeneous catalysis of dehydration. Herein, we developed a novel strategy by integrating a micro catalytic reactor onto the ion inlet of a high resolution Orbitrap mass spectrometry for high-speed, high-sensitive and high-throughput detection of the short-lives cationic species generated in the heterogeneous catalysis of short chain alcohols dehydration on γ-Al<sub>2</sub>O<sub>3</sub> or acidic zeolites HZSM-5. Finally, hundreds of cationic species could be feasibly observed within the HZSM-5 catalytic short chain alcohols dehydration.<b></b>
DOI: 10.6084/m9.figshare.6176072.v2
title: Profiling the Short-lives Cationic Species Generated within Catalytic Dehydration of Short Chain Alcohols

description: Short chain alcohols are important products of biomass conversion and can be further converted into platform chemicals through heterogeneous catalysis of dehydration. Herein, we developed a novel strategy by integrating a micro catalytic reactor onto the ion inlet of a high resolution Orbitrap mass spectrometry for high-speed, high-sensitive and high-throughput detection of the short-lives cationic species generated in the heterogeneous catalysis of short chain alcohols dehydration on γ-Al<sub>2</sub>O<sub>3</sub> or acidic zeolites HZSM-5. Finally, hundreds of cationic species could be feasibly observed within the HZSM-5 catalytic short chain alcohols dehydration.<b></b>
DOI: 10.6084/m9.figshare.6176072.v1
title: Profiling the Short-lives Cationic Species Generated within Catalytic Dehydration of Short Chain Alcohols

description: Short chain alcohols are important products of biomass conversion and can be further converted into platform chemicals through heterogeneous catalysis of dehydration. Herein, we developed a novel strategy by integrating a micro catalytic reactor onto the ion inlet of a high resolution Orbitrap mass spectrometry for high-speed, high-sensitive and high-throughput detection of the short-lives cationic species generated in the heterogeneous catalysis of short chain alcohols dehydration on γ-Al<sub>2</sub>O<sub>3</sub> or acidic zeolites HZSM-5. Finally, hundreds of cationic species could be feasibly observed within the HZSM-5 catalytic short chain alcohols dehydration.<b></b>
DOI: 10.6084/m9.figshare.6176063
title: Schoville 2018 - Trampling Artifact Coordinate Data

description: These are the starting coordinates and ending coordinates for the 300 artifacts trampled by animals in Northern California between August and December 2012.
DOI: 10.6084/m9.figshare.6176063.v1
title: Schoville 2018 - Trampling Artifact Coordinate Data

description: These are the starting coordinates and ending coordinates for the 300 artifacts trampled by animals in Northern California between August and December 2012.
DOI: 10.6084/m9.figshare.6175796
title: Supplementary material for the manuscript "Flexibility in the timing of avian egg-laying in relation to climate"

description: · Appendix S1 – Names of institutions and persons associated with the collection or maintenance of breeding observations. · Appendix S2 – Table of 146,009 occurrence records which includes the biome, observed 30-day T<sub>min</sub>, T<sub>max</sub>, and precipitation, and 2-year average T<sub>min</sub>, T<sub>max</sub>, and precipitation. · Appendix S3 – Species level climatic averages and results from paired <i>t</i>-tests.
DOI: 10.6084/m9.figshare.6175634
title: Additional file 7: of Comparative genomics of the wheat fungal pathogen Pyrenophora tritici-repentis reveals chromosomal variations and genome plasticity

description: RIPCAL2 summary for M4 RIP analysis. (XLSX 216Â kb)
DOI: 10.6084/m9.figshare.6175634.v1
title: Additional file 7: of Comparative genomics of the wheat fungal pathogen Pyrenophora tritici-repentis reveals chromosomal variations and genome plasticity

description: RIPCAL2 summary for M4 RIP analysis. (XLSX 216Â kb)
DOI: 10.6084/m9.figshare.6175628
title: Additional file 5: of Comparative genomics of the wheat fungal pathogen Pyrenophora tritici-repentis reveals chromosomal variations and genome plasticity

description: List of M4 de novo repeats and domains. (XLSX 29Â kb)
DOI: 10.6084/m9.figshare.6175628.v1
title: Additional file 5: of Comparative genomics of the wheat fungal pathogen Pyrenophora tritici-repentis reveals chromosomal variations and genome plasticity

description: List of M4 de novo repeats and domains. (XLSX 29Â kb)
DOI: 10.6084/m9.figshare.6175625
title: Additional file 4: of Comparative genomics of the wheat fungal pathogen Pyrenophora tritici-repentis reveals chromosomal variations and genome plasticity

description: M4 and BFP RepBase known repeat element summary. (XLSX 36Â kb)
DOI: 10.6084/m9.figshare.6175625.v1
title: Additional file 4: of Comparative genomics of the wheat fungal pathogen Pyrenophora tritici-repentis reveals chromosomal variations and genome plasticity

description: M4 and BFP RepBase known repeat element summary. (XLSX 36Â kb)
DOI: 10.6084/m9.figshare.6175616
title: Additional file 25: of Comparative genomics of the wheat fungal pathogen Pyrenophora tritici-repentis reveals chromosomal variations and genome plasticity

description: Supporting sequence data for DW7 and SD20. Sequence data for DW7 (SRR4026621-2) and SD20 (SRR06572) assembled for analysis in this study. (TXT 9982Â kb)