DOI: 10.5061/dryad.m484p
title: Data from: Association between serum γ-glutamyltranspeptidase and atherosclerosis: a population-based cross-sectional study

description: Objective: The purpose of this study was to determine the relationship
 between serum γ-glutamyltranspeptidase (GGT) and brachial-ankle pulse wave
 velocity (baPWV) as an indicator for atherosclerosis in Japanese men and
 women after adjusting for fatty liver. Design: A cross-sectional study.
 Setting: A health check-up centre in Japan. Participants: 912 Japanese men
 and women aged 24–84 years recruited from people who received a medical
 health check-up programme with a standardised questionnaire and an
 automatic waveform analyser to measure baPWV. Main outcome measures: We
 measured serum GGT concentrations and baPWV. Fatty liver was diagnosed by
 standardised criteria using abdominal ultrasonography. The postmenopausal
 state was defined as beginning 1 year after the cessation of menses.
 Results: In women, log2 GGT was positively associated with baPWV (β=0.11,
 95% CI 0.02 to 0.19, p&lt;0.05), independent of age, body mass index,
 systolic blood pressure, fasting plasma glucose, triglycerides, estimated
 glomerular filtration rate, fatty liver, menopausal state and parameters
 of lifestyles. However, in men, the positive association of log2 GGT with
 baPWV was not significant (β=−0.04, 95% CI −0.10 to 0.03, p=0.28) in
 multivariable linear regression analyses. Conclusions: The serum GGT level
 was associated with baPWV, independently of covariates including fatty
 liver or menopausal state just in women, but not in men.
description: The positive association
 of serum gamma-glutamyltranspeptidase with atherosclerosis in females, not
 in males: a population based large scale cross-sectional
 studyObjective: The purpose
 of this study was to determine the relationship between serum
 gamma-glutamyltranspeptidase (GGT) and brachial-ankle pulse wave velocity
 (baPWV) as an indicator for atherosclerosis in Japanese males and females
 after adjusting fatty liver. Design: A cross-sectional study. Setting: A
 health checkup center in Japan. Participants: 846 Japanese males and
 females aged 24-84 years recruited from people who received a medical
 health checkup program with a standardized questionnaire and an automatic
 waveform analyzer to measure baPWV. Main outcome measures: We measured
 serum GGT concentrations and baPWV. Fatty liver was diagnosed by a
 standardized criteria using with abdominal ultrasonography. The
 postmenopausal state was defined as beginning 1 year after the cessation
 of menses. Results: In females, log2 GGT was positively associated with
 baPWV (β=0.11, 95% confidence interval (CI) 0.02-0.19, p&lt;0.05)
 independent on age, BMI, systolic blood pressure, fasting plasma glucose,
 triglycerides, estimated glomerular ratio, fatty liver, menopausal state
 and parameters of life styles. However, in males, the positive association
 of log2 GGT with baPWV was not significant (β=-0.04, 95% CI -0.10-0.03,
 p=0.28) in multivariable linear regression analyses. Conclusions: The
 serum GGT level was associated with baPWV independently on co -variate
 including fatty liver or menopausal state just in females, but not in
 males. When the elevation of GGT was observed in females at clinical
 practice, we should check them using with some screening tests for
 atherosclerosis including baPWV.data bmjopen
 dryad.xls