cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.12199883
title: Identification of novel adipokines differential regulated in C57BL/Ks and C57BL/6

description: Visceral adiposity is associated with metabolic disorders, but little is known on the underlying pathophysiological mechanism. One possible link might be the release of various signalling and mediator proteins, named adipokines. Our hypothesis was that dependent on genetic background factors are released which might trigger a primary disease susceptibility. This study characterizes the adipokines released from visceral adipose tissue from two metabolic healthy mouse strains, i.e. C57BL/Ks (BKS) and C57BL/6 (C57), of which the former genetic background is more sensitive to develop diabetes following metabolic challenge. Using liquid chromatography (LC)-electrospray ionization (ESI)-MS/MS, a reference map comprising 597 adipokines was generated (http://www.diabesityprot.org). Thirty-five adipokines, including six not previously described ones, were differentially released between the mouse strains. Most notable is the reduced release of the adiponectin-binding protein T-Cadherin (CAD13) in BKS mice. This observation highlights the importance of secretome profiling in unravelling the complex interplay between genetic diversity and lifestyle.
DOI: 10.6084/m9.figshare.12200000.v1
title: The development of an mHealth educational intervention for first-time hearing aid users: combining theoretical and ecologically valid approaches

description: <b>Objective:</b> This paper describes the development of a novel mobile health (mHealth) educational intervention, called m2Hear, designed for first-time hearing aid users based on previously developed educational multimedia videos, or reusable learning objects (RLOs), branded C2Hear. <b>Design:</b> The development of m2Hear used theoretical and ecologically valid approaches. The COM-B model and associated Theoretical Domains Framework were employed to identify specific components (or “active ingredients”) of the original RLOs that facilitate hearing aid use. An mHealth platform was then developed following an iterative, user-centred and participatory design approach. <b>Study sample:</b> Fifteen existing hearing aid users completed synchronous, real-time Think Aloud interviews. A sub-group of these participants (<i>n</i> = 5), along with patient and public involvement panel members (<i>n</i> = 4), subsequently reviewed the usability of the mHealth platform. <b>Results:</b> While factors associated with Capability featured strongly across all RLOs, topics relating to Opportunity and Motivation were also incorporated. The RLOs were broken-down into 42 shorter mobile-enhanced RLOs (or mRLOs). Each mRLO was labelled with a specific user-centred question generated from the Think Aloud interviews. The final mHealth platform was developed following four separate usability iterations. <b>Conclusions:</b> Overall, m2Hear provides greater opportunities for individualised learning and encourages greater interaction to facilitate self-management in first-time hearing aid users.
DOI: 10.6084/m9.figshare.12200000.v3
title: The development of an mHealth educational intervention for first-time hearing aid users: combining theoretical and ecologically valid approaches

description: <b>Objective:</b> This paper describes the development of a novel mobile health (mHealth) educational intervention, called m2Hear, designed for first-time hearing aid users based on previously developed educational multimedia videos, or reusable learning objects (RLOs), branded C2Hear. <b>Design:</b> The development of m2Hear used theoretical and ecologically valid approaches. The COM-B model and associated Theoretical Domains Framework were employed to identify specific components (or “active ingredients”) of the original RLOs that facilitate hearing aid use. An mHealth platform was then developed following an iterative, user-centred and participatory design approach. <b>Study sample:</b> Fifteen existing hearing aid users completed synchronous, real-time Think Aloud interviews. A sub-group of these participants (<i>n</i> = 5), along with patient and public involvement panel members (<i>n</i> = 4), subsequently reviewed the usability of the mHealth platform. <b>Results:</b> While factors associated with Capability featured strongly across all RLOs, topics relating to Opportunity and Motivation were also incorporated. The RLOs were broken-down into 42 shorter mobile-enhanced RLOs (or mRLOs). Each mRLO was labelled with a specific user-centred question generated from the Think Aloud interviews. The final mHealth platform was developed following four separate usability iterations. <b>Conclusions:</b> Overall, m2Hear provides greater opportunities for individualised learning and encourages greater interaction to facilitate self-management in first-time hearing aid users.
DOI: 10.6084/m9.figshare.12199883.v1
title: Identification of novel adipokines differential regulated in C57BL/Ks and C57BL/6

description: Visceral adiposity is associated with metabolic disorders, but little is known on the underlying pathophysiological mechanism. One possible link might be the release of various signalling and mediator proteins, named adipokines. Our hypothesis was that dependent on genetic background factors are released which might trigger a primary disease susceptibility. This study characterizes the adipokines released from visceral adipose tissue from two metabolic healthy mouse strains, i.e. C57BL/Ks (BKS) and C57BL/6 (C57), of which the former genetic background is more sensitive to develop diabetes following metabolic challenge. Using liquid chromatography (LC)-electrospray ionization (ESI)-MS/MS, a reference map comprising 597 adipokines was generated (http://www.diabesityprot.org). Thirty-five adipokines, including six not previously described ones, were differentially released between the mouse strains. Most notable is the reduced release of the adiponectin-binding protein T-Cadherin (CAD13) in BKS mice. This observation highlights the importance of secretome profiling in unravelling the complex interplay between genetic diversity and lifestyle.
DOI: 10.6084/m9.figshare.12200000.v2
title: The development of an mHealth educational intervention for first-time hearing aid users: combining theoretical and ecologically valid approaches

description: <b>Objective:</b> This paper describes the development of a novel mobile health (mHealth) educational intervention, called m2Hear, designed for first-time hearing aid users based on previously developed educational multimedia videos, or reusable learning objects (RLOs), branded C2Hear. <b>Design:</b> The development of m2Hear used theoretical and ecologically valid approaches. The COM-B model and associated Theoretical Domains Framework were employed to identify specific components (or “active ingredients”) of the original RLOs that facilitate hearing aid use. An mHealth platform was then developed following an iterative, user-centred and participatory design approach. <b>Study sample:</b> Fifteen existing hearing aid users completed synchronous, real-time Think Aloud interviews. A sub-group of these participants (<i>n</i> = 5), along with patient and public involvement panel members (<i>n</i> = 4), subsequently reviewed the usability of the mHealth platform. <b>Results:</b> While factors associated with Capability featured strongly across all RLOs, topics relating to Opportunity and Motivation were also incorporated. The RLOs were broken-down into 42 shorter mobile-enhanced RLOs (or mRLOs). Each mRLO was labelled with a specific user-centred question generated from the Think Aloud interviews. The final mHealth platform was developed following four separate usability iterations. <b>Conclusions:</b> Overall, m2Hear provides greater opportunities for individualised learning and encourages greater interaction to facilitate self-management in first-time hearing aid users.
DOI: 10.6084/m9.figshare.12199835
title: RPPA data

description: RPPA data
DOI: 10.6084/m9.figshare.12199790
title: Oxytocin on alcohol craving and relapse

description: <br> <b>Baselinedata: </b> Dataset: Output: Table 1_baseline_Part 2_output.spv <b>Kaplan Meier Survival: </b> Dataset: Varighet_opphold_LBS.sav Output: 190920_Kaplan-Meier_alko.spv <b>Mixed models: </b> Dataset: Fullstendig_dag28_pasientdagbok_mixed_models.sav Output: 191030_mixed_models_28_KI.spv <b>T-test: </b> Dataset: Fullstendig_Dag ca 30 - kontrolltime.sav evt Data_Dag_30_drop-outs_relapse.sav – ACQ-SF-R/HSCL-10 Output: <b>Nye analyser (i mappa: Neuropsychopharmacology Reports/Tabeller og figurer/drop-out=missing 25.03.20: </b> 1. Alle drop out = relapse. Kaplan Meier survival: 200424_Baseline_subgroups_kaplan_meier<br> 2. Subgrupper dager til relapse. Kaplan Meier survival: Output_25.03.20 PEth &lt;= 2, &gt; 2 og alkoholenheter &lt;= 16, &gt; 16 <b></b><i></i><sub></sub><sup></sup><br>
DOI: 10.6084/m9.figshare.12199790.v1
title: Oxytocin on alcohol craving and relapse

description: <br> <b>Baselinedata: </b> Dataset: Output: Table 1_baseline_Part 2_output.spv <b>Kaplan Meier Survival: </b> Dataset: Varighet_opphold_LBS.sav Output: 190920_Kaplan-Meier_alko.spv <b>Mixed models: </b> Dataset: Fullstendig_dag28_pasientdagbok_mixed_models.sav Output: 191030_mixed_models_28_KI.spv <b>T-test: </b> Dataset: Fullstendig_Dag ca 30 - kontrolltime.sav evt Data_Dag_30_drop-outs_relapse.sav – ACQ-SF-R/HSCL-10 Output: <b>Nye analyser (i mappa: Neuropsychopharmacology Reports/Tabeller og figurer/drop-out=missing 25.03.20: </b> 1. Alle drop out = relapse. Kaplan Meier survival: 200424_Baseline_subgroups_kaplan_meier<br> 2. Subgrupper dager til relapse. Kaplan Meier survival: Output_25.03.20 PEth &lt;= 2, &gt; 2 og alkoholenheter &lt;= 16, &gt; 16 <b></b><i></i><sub></sub><sup></sup><br>
DOI: 10.6084/m9.figshare.12199754
title: Wolbachia community acceptance survey

description: De-identified individual level results of baseline (2015) and pre-release (2016) household surveys of community acceptance of <i>Wolbachia </i>mosquito releases as a method for controlling dengue, in the quasi-experimental study intervention area in Yogyakarta, Indonesia. As described in Indriani et al (2020) submitted to Gates Open Research.
DOI: 10.6084/m9.figshare.12199745
title: raw data for D12 and D18/19 immunocytochemistry

description: Raw data for Figure 3<br><br>Images were taken with IX70 inverted epifluorescence microscope (Olympus) connected to AxioVision imaging software 4.4. ImageJ 1.49c was used to generate TIFF files.<br><br>
DOI: 10.6084/m9.figshare.12199760
title: GWAS elite endurance athletes

description: <b>Genome-wide association study reveals a novel association between gene polymorphism, endurance athlete status, aerobic capacity and steroid metabolism</b>
DOI: 10.6084/m9.figshare.12199745.v1
title: raw data for D12 and D18/19 immunocytochemistry

description: Raw data for Figure 3<br><br>Images were taken with IX70 inverted epifluorescence microscope (Olympus) connected to AxioVision imaging software 4.4. ImageJ 1.49c was used to generate TIFF files.<br><br>
DOI: 10.6084/m9.figshare.12199721
title: raw data for Genotyping

description: Gel image used in Figure 1<br>Genomic DNA from human iPSCs amplified for the APOE locus, then digested with HhaI enzyme. Run on 3% agarose gel.<br>Genotype of the cell line used in this study was compared to that of another cell line maintained in the lab that was known to be homozygous for APOE3.<br>Genotyping method based on Henderson et al. (2002).Henderson, J.N., Crook, R., Crook, J., et al. 2002. Apolipoprotein E4 and tau allele frequencies among Choctaw Indians. <i>Neuroscience Letters</i> 324(1), pp. 77–79.
DOI: 10.6084/m9.figshare.12199688
title: Figure 5_6_DengueCaseData

description: Data underlying Figure 5 (Dengue incidence in intervention and control areas, before and after the <i>Wolbachia </i>intervention) and Figure 6 (Laboratory-confirmed dengue cases in intervention and control areas, before and after the <i>Wolbachia </i>intervention), in Indriani et al (2020) <i>Gates Open Research (submitted)</i>. Hospitalised dengue haemorrhagic fever (DHF; since 2006) and dengue fever (DF; since 2017) cases are notified to the Yogyakarta District Health Office. Standard Diagnostics Dengue Duo rapid diagnostic kits for the detection of dengue virus NS1 antigen and IgM/IgG antibody have been used at the discretion of clinic staff as part of routine clinical care in primary care clinics throughout Yogyakarta city since March 2016.
DOI: 10.6084/m9.figshare.12199688.v2
title: Figure 5_6_DengueCaseData

description: Data underlying Figure 5 (Dengue incidence in intervention and control areas, before and after the <i>Wolbachia </i>intervention) and Figure 6 (Laboratory-confirmed dengue cases in intervention and control areas, before and after the <i>Wolbachia </i>intervention), in Indriani et al (2020) <i>Gates Open Research (submitted)</i>. Hospitalised dengue haemorrhagic fever (DHF; since 2006) and dengue fever (DF; since 2017) cases are notified to the Yogyakarta District Health Office. Standard Diagnostics Dengue Duo rapid diagnostic kits for the detection of dengue virus NS1 antigen and IgM/IgG antibody have been used at the discretion of clinic staff as part of routine clinical care in primary care clinics throughout Yogyakarta city since March 2016.
DOI: 10.6084/m9.figshare.12199604
title: Estimates of environmental loading from copper alloy materials

description: Metal release rates were measured from four different copper alloy-based materials used by the aquaculture industry: copper sheet machined into a diamond mesh, copper alloy mesh (CAM), silicon bronze welded wire mesh, and copper sheeting, and compared with conventional nylon aquaculture net treated with a cuprous oxide antifouling (AF) coating. Release rates were measured <i>in situ</i> in San Diego Bay using a Navy-developed Dome enclosure system at nine different time points over one year. As expected, copper was the predominant metal released, followed by zinc and nickel, which were fractional components of the materials tested. Release rates followed a temporal trend similar to those observed with copper AF coatings applied to vessel hulls: an initial spike in copper release was followed by a decline to an asymptotic low. Leachate toxicity was consistent with prior studies and was directly related to the metal concentrations, indicating the alloys tested had no additional toxicity above pure metals.
DOI: 10.6084/m9.figshare.12199604.v1
title: Estimates of environmental loading from copper alloy materials

description: Metal release rates were measured from four different copper alloy-based materials used by the aquaculture industry: copper sheet machined into a diamond mesh, copper alloy mesh (CAM), silicon bronze welded wire mesh, and copper sheeting, and compared with conventional nylon aquaculture net treated with a cuprous oxide antifouling (AF) coating. Release rates were measured <i>in situ</i> in San Diego Bay using a Navy-developed Dome enclosure system at nine different time points over one year. As expected, copper was the predominant metal released, followed by zinc and nickel, which were fractional components of the materials tested. Release rates followed a temporal trend similar to those observed with copper AF coatings applied to vessel hulls: an initial spike in copper release was followed by a decline to an asymptotic low. Leachate toxicity was consistent with prior studies and was directly related to the metal concentrations, indicating the alloys tested had no additional toxicity above pure metals.
DOI: 10.6084/m9.figshare.12199436
title: COPD microbiome meta-analysis data (April 2020)

description: This is a re-analysis of public COPD microbiome (sputum only) and host transcriptome datasets.
DOI: 10.6084/m9.figshare.12199451
title: Example input files for MEANGS test

description: Pair-end NGS data from human Re-seq, which were modified for input of a newly developed mitochondiral genome assember. https://github.com/YanCCscu/MEANGS
DOI: 10.6084/m9.figshare.12199451.v1
title: example input for MEANGS test

description: Pair-end NGS data from human Re-seq, which were modified for input of a newly developed mitochondiral genome assember.
DOI: 10.6084/m9.figshare.12199451.v3
title: Example input files for MEANGS test

description: Pair-end NGS data from human Re-seq, which were modified for input of a newly developed mitochondiral genome assember. https://github.com/YanCCscu/MEANGS
DOI: 10.6084/m9.figshare.12199451.v2
title: Example input for MEANGS test

description: Pair-end NGS data from human Re-seq, which were modified for input of a newly developed mitochondiral genome assember. https://github.com/YanCCscu/MEANGS
DOI: 10.6084/m9.figshare.12199088
title: Metadata record for: Database of literature derived cellular measurements from the murine basal ganglia

description: This dataset contains key characteristics about the data described in the Data Descriptor Database of literature derived cellular measurements from the murine basal ganglia. <br> Contents: <br> 1. human readable metadata summary table in CSV format 2. machine readable metadata file in JSON format <br> <br> <br>
DOI: 10.6084/m9.figshare.12199088.v1
title: Metadata record for: Database of literature derived cellular measurements from the murine basal ganglia

description: This dataset contains key characteristics about the data described in the Data Descriptor Database of literature derived cellular measurements from the murine basal ganglia. <br> Contents: <br> 1. human readable metadata summary table in CSV format 2. machine readable metadata file in JSON format <br> <br> <br>
DOI: 10.6084/m9.figshare.12199053
title: liver function after major hepatectomy

description: A total of 218 patients diagnosed with HCC who underwent major hepatectomy were finally enrolled for this study. The patients received different vasoactive agents after hepatectomy. They were divided into three intervention groups: terlipressin (n = 64), somatostatin (n = 48), and combination (terlipressin+somatostatin, n = 34), and a control group (n = 72), In this EXCEL prolie, including sex, age, diabetes, HBsAg, preoperative parameters (albumin, PT, TB, ascites, cirrhosis), number of tumors, total diameter of tumors, segments of resection, and intraoperative bleeding. liver function (alanine transaminase [ALT], PT, and TB levels on POD 1, 3, and 5, and their peak levels) and ascites were analyzed.
DOI: 10.6084/m9.figshare.12199050

description: see README.md
DOI: 10.6084/m9.figshare.12199053.v1
title: liver function after major hepatectomy

description: A total of 218 patients diagnosed with HCC who underwent major hepatectomy were finally enrolled for this study. The patients received different vasoactive agents after hepatectomy. They were divided into three intervention groups: terlipressin (n = 64), somatostatin (n = 48), and combination (terlipressin+somatostatin, n = 34), and a control group (n = 72), In this EXCEL prolie, including sex, age, diabetes, HBsAg, preoperative parameters (albumin, PT, TB, ascites, cirrhosis), number of tumors, total diameter of tumors, segments of resection, and intraoperative bleeding. liver function (alanine transaminase [ALT], PT, and TB levels on POD 1, 3, and 5, and their peak levels) and ascites were analyzed.
DOI: 10.6084/m9.figshare.12199038
title: COVID-19 related Weibo Data from "Did the world overlook the media’s early warning of COVID-19?"

description: Between December 1, 2019 and February 27, 2020, Weiboscope collected 11,362,502 posts, among which 1,230,353 contain at least an outbreak-related keyword (please refer to the paper) and 2,104 (1.7 per 1,000) have been censored.<br>Data fields:Column 1: "created_at": date of publicationColumn 2: "censorship_type": directly censored (return of "permission_denied") or retweet of censored post ("retweet of a “permission denied” post")Column 3: "id_hashed": hashed post ID Column 4: "retweeted_status_hashed": hashed retweet statusColumn 5: "text_cleaned": text body with all @XXX mentions removed<br>Please cite the referenceKing-wa Fu & Yuner Zhu (2020) Did the world overlook the media’s early warning of COVID-19?, Journal of Risk Research, DOI: 10.1080/13669877.2020.1756380<br><br>
DOI: 10.6084/m9.figshare.12199050.v1
title: Evaluation_processing.zip

description: see README.md
DOI: 10.6084/m9.figshare.12199041
title: Source Code from Parameter subset reduction for patient-specific modelling of arrhythmogenic cardiomyopathy-related mutation carriers in the CircAdapt model

description: Arrhythmogenic cardiomyopathy (AC) is an inherited cardiac disease, clinically characterized by life-threatening ventricular arrhythmias and progressive cardiac dysfunction. Patient-specific computational models could help understand the disease progression and may help in clinical decision-making. We propose an inverse modelling approach using the CircAdapt model to estimate patient-specific regional abnormalities in tissue properties in AC subjects. However, the number of parameters (<i>n</i> = 110) and their complex interactions make personalized parameter estimation challenging. The goal of this study is to develop a framework for parameter reduction and estimation combining Morris screening, quasi-Monte Carlo (qMC) simulations and particle swarm optimization (PSO). This framework identifies the best subset of tissue properties based on clinical measurements allowing patient-specific identification of right ventricular tissue abnormalities. We applied this framework on 15 AC genotype-positive subjects with varying degrees of myocardial disease. Cohort studies have shown that atypical regional right ventricular (RV) deformation patterns reveal an early-stage AC disease. The CircAdapt model of cardiovascular mechanics and hemodynamics already demonstrated its ability to capture typical deformation patterns of AC subjects. We, therefore, use clinically measured cardiac deformation patterns to estimate model parameters describing myocardial disease substrates underlying these AC-related RV deformation abnormalities. Morris screening reduced the subset to 48 parameters. qMC and PSO further reduced the subset to a final selection of 16 parameters, including regional tissue contractility, passive stiffness, activation delay and wall reference area.This article is part of the theme issue ‘Uncertainty Quantification in Cardiac and Cardiovascular Modelling and Simulation’.