cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.5281/zenodo.13773117
title: Transitive prediction of small molecule function through alignment of high-content screening resources

description: This dataset supports the development of CLIP<sup>n</sup>, a contrastive-learning framework designed to align heterogeneous high-content screening (HCS) profile datasets.

GitHub link: https://github.com/AltschulerWu-Lab/CLIPn

Directory Structure

Data Files



HCS_datasets.pkl: Contains 13 high-content screening (HCS) datasets from multiple studies across 20 years.

Hypoxia.pkl: Contains 8 profile datasets using different assays and treated under diverse hypoxia durations.

Expression.pkl: Contains 2 transcriptional profile datasets and 6 image profile datasets for multimodal analysis.


Folders

raw_profiles:HCS13/- Contains raw data from 13 high-content screening (HCS) datasets. Each dataset includes meta and feature files. 

L1000/- CDRP_feature_exp.csv: Raw L1000 expression data from the CDRP dataset.- CDRP_meta_exp.csv: Metadata associated with the CDRP expression data.- LINCS_feature_exp.csv: Raw L1000 expression data from the LINCS dataset.- LINCS_meta_exp.csv: Metadata associated with the LINCS expression data.

RxRx3/- RxRx3_feature_final.csv: Profile data from the RxRx3 dataset.- RxRx3_meta_final.csv: Metadata from the RxRx3 dataset.

Uncharacterized_compounds/- NCI_cpnData.csv: Feature data for uncharacterized compounds from the NCI dataset.- NCI_cpnInfo.csv: Information about uncharacterized compounds in the NCI dataset.- Prestwick_UTSW_cpnData.csv: Feature data for uncharacterized compounds from the Prestwick UTSW dataset.- Prestwick_UTSW_cpnInfo.csv: Information about uncharacterized compounds from the Prestwick UTSW dataset.

Usage

import picklewith open('data.pkl', 'rb') as f:    data = pickle.load(f)

X = data['X']y = data['y']

Data Reference

For raw datasets from 13 HCS database, data and analysis pipeline for dataset 1 was obtained from https://www.science.org/doi/suppl/10.1126/science.1100709/suppl_file/perlman.som.zip; for datasets 2-3, data were shared by authors; For datasets 4-5, analysis code was downloaded from https://static-content.springer.com/esm/art%3A10.1038%2Fnbt.3419/MediaObjects/41587_2016_BFnbt3419_MOESM21_ESM.zip and data were shared by authors; For datasets 6-7, processed dataset was downloaded from AWS following instructions from https://github.com/carpenter-singh-lab/2022_Haghighi_NatureMethods, and replicate_level_cp_normalized.csv.gz features were used. For project datasets 8-13, datasets and analysis results were downloaded from https://zenodo.org/records/7352487. For RxRx3, dataset was obtained from https://www.rxrx.ai/rxrx3. L1000 transcript datasets were downloaded using the same link as datasets 6-7 and the processed transcript data files (named “replicate_level_l1k.csv”) were used.
DOI: 10.15468/dl.ew6f3n
title: Occurrence Download

description: A dataset containing 2857522 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is Denmark",
 "OccurrenceStatus is Present",
 "CoordinateUncertaintyInMeters is less than 50000",
 "Year is 2020",
 "DecimalLongitude is greater than or equal to 7.0",
 "DecimalLongitude is less than or equal to 13.0",
 "DecimalLatitude is greater than or equal to 54.5",
 "DecimalLatitude is less than or equal to 58.0"
 ]
}

 The dataset includes 2857522 records from 32 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0022246-241007104925546/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.r435ub
title: Occurrence Download

description: A dataset containing 124 species occurrences available in GBIF matching the query:
{
 "and" : [
 {
 "and" : [
 "HasGeospatialIssue is false",
 "HasCoordinate is true",
 "OccurrenceStatus is Present",
 {
 "not" : {
 "BasisOfRecord" : [
 "is one of (Fossil, Living Specimen)"
 ]
 }
 }
 ]
 },
 "TaxonKey is Protoribates capucinus Berlese, 1908",
 "PhylumKey is Arthropoda",
 "Year is greater than or equal to 1992",
 "Year is less than or equal to 2012",
 "Geometry POLYGON((-26 34, 42 34, 42 70, -26 70, -26 34))"
 ]
}

 The dataset includes 124 records from 11 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0022303-241007104925546/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.2a6s67
title: Occurrence Download

description: A dataset containing 922 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Handroanthus guayacan (Seem.) S.O.Grose"
 ]
}

 The dataset includes 922 records from 97 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0022304-241007104925546/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.hz9ebz
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 {
 "and" : [
 "HasGeospatialIssue is false",
 "HasCoordinate is true",
 "OccurrenceStatus is Present",
 {
 "not" : {
 "BasisOfRecord" : [
 "is one of (Fossil, Living Specimen)"
 ]
 }
 }
 ]
 },
 "TaxonKey is Pseudotectoribates subsimilis (Mihelcic, 1956)",
 "PhylumKey is Arthropoda",
 "Year is greater than or equal to 1992",
 "Year is less than or equal to 2012",
 "Geometry POLYGON((-26 34, 42 34, 42 70, -26 70, -26 34))"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0022305-241007104925546/datasets/export for details.
DOI: 10.15468/dl.d5pq59
title: Occurrence Download

description: A dataset containing 22 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Telmatobius gigas Vellard, 1969"
 ]
}

 The dataset includes 22 records from 5 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0022306-241007104925546/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.mxgcdq
title: Occurrence Download

description: A dataset containing 42 species occurrences available in GBIF matching the query:
{
 "and" : [
 {
 "and" : [
 "HasGeospatialIssue is false",
 "HasCoordinate is true",
 "OccurrenceStatus is Present",
 {
 "not" : {
 "BasisOfRecord" : [
 "is one of (Fossil, Living Specimen)"
 ]
 }
 }
 ]
 },
 "TaxonKey is Ramusella elliptica (Berlese, 1908)",
 "PhylumKey is Arthropoda",
 "Year is greater than or equal to 1992",
 "Year is less than or equal to 2012",
 "Geometry POLYGON((-26 34, 42 34, 42 70, -26 70, -26 34))"
 ]
}

 The dataset includes 42 records from 7 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0022307-241007104925546/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.mg6pg3
title: Occurrence Download

description: A dataset listing the 466 species recorded in GBIF matching the query:
{
 "and" : [
 "Geometry POLYGON((-122.9354 49.15145,-122.93543 49.14916,-122.93441 49.14734,-122.93441 49.14622,-122.93557 49.14519,-122.93646 49.14407,-122.93606 49.14145,-122.93401 49.13917,-122.92951 49.13407,-122.92911 49.13344,-122.91888 49.13321,-122.91855 49.13596,-122.91984 49.13937,-122.92246 49.14268,-122.9354 49.15145))",
 "OccurrenceStatus is Present"
 ]
}

 The dataset's 466 records were derived from 14 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0022290-241007104925546/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.yrc5x9
title: Occurrence Download

description: A dataset containing 50 species occurrences available in GBIF matching the query:
{
 "and" : [
 {
 "and" : [
 "HasGeospatialIssue is false",
 "HasCoordinate is true",
 "OccurrenceStatus is Present",
 {
 "not" : {
 "BasisOfRecord" : [
 "is one of (Fossil, Living Specimen)"
 ]
 }
 }
 ]
 },
 "TaxonKey is Ramusella insculpta (Paoli, 1908)",
 "PhylumKey is Arthropoda",
 "Year is greater than or equal to 1992",
 "Year is less than or equal to 2012",
 "Geometry POLYGON((-26 34, 42 34, 42 70, -26 70, -26 34))"
 ]
}

 The dataset includes 50 records from 8 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0022308-241007104925546/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.r3shks
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 {
 "and" : [
 "HasGeospatialIssue is false",
 "HasCoordinate is true",
 "OccurrenceStatus is Present",
 {
 "not" : {
 "BasisOfRecord" : [
 "is one of (Fossil, Living Specimen)"
 ]
 }
 }
 ]
 },
 "TaxonKey is Ramusella terricola Subías & Rodríguez, 1986",
 "PhylumKey is Arthropoda",
 "Year is greater than or equal to 1992",
 "Year is less than or equal to 2012",
 "Geometry POLYGON((-26 34, 42 34, 42 70, -26 70, -26 34))"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0022309-241007104925546/datasets/export for details.
DOI: 10.15468/dl.64c8kr
title: Occurrence Download

description: A dataset containing 41 species occurrences available in GBIF matching the query:
{
 "and" : [
 {
 "and" : [
 "HasGeospatialIssue is false",
 "HasCoordinate is true",
 "OccurrenceStatus is Present",
 {
 "not" : {
 "BasisOfRecord" : [
 "is one of (Fossil, Living Specimen)"
 ]
 }
 }
 ]
 },
 "TaxonKey is Ramusella clavipectinata (Michael, 1885)",
 "PhylumKey is Arthropoda",
 "Year is greater than or equal to 1992",
 "Year is less than or equal to 2012",
 "Geometry POLYGON((-26 34, 42 34, 42 70, -26 70, -26 34))"
 ]
}

 The dataset includes 41 records from 10 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0022310-241007104925546/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.686279
title: Occurrence Download

description: A dataset containing 6 species occurrences available in GBIF matching the query:
{
 "and" : [
 {
 "and" : [
 "HasGeospatialIssue is false",
 "HasCoordinate is true",
 "OccurrenceStatus is Present",
 {
 "not" : {
 "BasisOfRecord" : [
 "is one of (Fossil, Living Specimen)"
 ]
 }
 }
 ]
 },
 "TaxonKey is Ramusella puertomonttensis Hammer, 1962",
 "PhylumKey is Arthropoda",
 "Year is greater than or equal to 1992",
 "Year is less than or equal to 2012",
 "Geometry POLYGON((-26 34, 42 34, 42 70, -26 70, -26 34))"
 ]
}

 The dataset includes 6 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0022311-241007104925546/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.3vanq4
title: Occurrence Download

description: A dataset containing 24930 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Geometry POLYGON((-82.54949 27.94552,-82.53236 27.94552,-82.53236 27.95405,-82.54949 27.95405,-82.54949 27.94552))",
 "OccurrenceStatus is Present"
 ]
}

 The dataset includes 24930 records from 8 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0022312-241007104925546/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.69hjft
title: Occurrence Download

description: A dataset containing 12 species occurrences available in GBIF matching the query:
{
 "and" : [
 {
 "and" : [
 "HasGeospatialIssue is false",
 "HasCoordinate is true",
 "OccurrenceStatus is Present",
 {
 "not" : {
 "BasisOfRecord" : [
 "is one of (Fossil, Living Specimen)"
 ]
 }
 }
 ]
 },
 "TaxonKey is Ramusella fasciata (Paoli, 1908)",
 "PhylumKey is Arthropoda",
 "Year is greater than or equal to 1992",
 "Year is less than or equal to 2012",
 "Geometry POLYGON((-26 34, 42 34, 42 70, -26 70, -26 34))"
 ]
}

 The dataset includes 12 records from 5 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0022313-241007104925546/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.6ustv8
title: Occurrence Download

description: A dataset containing 116 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Telmatobius hintoni Parker, 1940"
 ]
}

 The dataset includes 116 records from 11 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0022314-241007104925546/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.n39uqf
title: Occurrence Download

description: A dataset containing 5 species occurrences available in GBIF matching the query:
{
 "and" : [
 {
 "and" : [
 "HasGeospatialIssue is false",
 "HasCoordinate is true",
 "OccurrenceStatus is Present",
 {
 "not" : {
 "BasisOfRecord" : [
 "is one of (Fossil, Living Specimen)"
 ]
 }
 }
 ]
 },
 "TaxonKey is Ramusella mihelcici (Pérez-Íñigo, 1965)",
 "PhylumKey is Arthropoda",
 "Year is greater than or equal to 1992",
 "Year is less than or equal to 2012",
 "Geometry POLYGON((-26 34, 42 34, 42 70, -26 70, -26 34))"
 ]
}

 The dataset includes 5 records from 3 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0022315-241007104925546/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.wja2ex
title: Occurrence Download

description: A dataset containing 77 species occurrences available in GBIF matching the query:
{
 "and" : [
 {
 "and" : [
 "HasGeospatialIssue is false",
 "HasCoordinate is true",
 "OccurrenceStatus is Present",
 {
 "not" : {
 "BasisOfRecord" : [
 "is one of (Fossil, Living Specimen)"
 ]
 }
 }
 ]
 },
 "TaxonKey is Rhysotritia ardua (Koch, 1841)",
 "PhylumKey is Arthropoda",
 "Year is greater than or equal to 1992",
 "Year is less than or equal to 2012",
 "Geometry POLYGON((-26 34, 42 34, 42 70, -26 70, -26 34))"
 ]
}

 The dataset includes 77 records from 14 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0022316-241007104925546/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.w2yafh
title: Occurrence Download

description: A dataset containing 399 species occurrences available in GBIF matching the query:
{
 "and" : [
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 "TaxonKey is Cassia alata L."
 ]
}

 The dataset includes 399 records from 64 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0022318-241007104925546/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.y2wxyj
title: Occurrence Download

description: A dataset containing 278 species occurrences available in GBIF matching the query:
{
 "and" : [
 {
 "and" : [
 "HasGeospatialIssue is false",
 "HasCoordinate is true",
 "OccurrenceStatus is Present",
 {
 "not" : {
 "BasisOfRecord" : [
 "is one of (Fossil, Living Specimen)"
 ]
 }
 }
 ]
 },
 "TaxonKey is Scheloribates latipes (Koch, 1844)",
 "PhylumKey is Arthropoda",
 "Year is greater than or equal to 1992",
 "Year is less than or equal to 2012",
 "Geometry POLYGON((-26 34, 42 34, 42 70, -26 70, -26 34))"
 ]
}

 The dataset includes 278 records from 16 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0022317-241007104925546/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.26093/cds/vizier.36610118
title: 628 new open clusters found with OCfinder

description: VizieR online Data Catalogue associated with article published in journal Astronomy and Astrophysics with title ' Hunting for open clusters in Gaia EDR3: 628 new open clusters found with OCfinder.' (bibcode: 2022A&A...661A.118C)
DOI: 10.26093/cds/vizier.36650100
title: AMICO galaxy clusters in KiDS-DR3

description: VizieR online Data Catalogue associated with article published in journal Astronomy and Astrophysics with title ' AMICO galaxy clusters in KiDS-DR3: Constraints on cosmological parameters and on the normalisation of the mass-richness relation from clustering.' (bibcode: 2022A&A...665A.100L)
DOI: 10.26093/cds/vizier.36650057
title: Substructure in the stellar halo near the Sun. I.

description: VizieR online Data Catalogue associated with article published in journal Astronomy and Astrophysics with title ' Substructure in the stellar halo near the Sun. I. Data-driven clustering in integrals-of-motion space.' (bibcode: 2022A&A...665A..57L)
DOI: 10.26093/cds/vizier.36660029
title: M83 PNe in MUSE+HST dataset

description: VizieR online Data Catalogue associated with article published in journal Astronomy and Astrophysics with title ' Stellar feedback in M 83 as observed with MUSE. II. Analysis of the H II region population: Ionisation budget and pre-SN feedback.' (bibcode: 2022A&A...666A..29D)
DOI: 10.15468/dl.2y852v
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 {
 "and" : [
 "HasGeospatialIssue is false",
 "HasCoordinate is true",
 "OccurrenceStatus is Present",
 {
 "not" : {
 "BasisOfRecord" : [
 "is one of (Fossil, Living Specimen)"
 ]
 }
 }
 ]
 },
 "TaxonKey is Scheloribates minifimbriatus Mínguez, Subías & Ruiz, 1986",
 "PhylumKey is Arthropoda",
 "Year is greater than or equal to 1992",
 "Year is less than or equal to 2012",
 "Geometry POLYGON((-26 34, 42 34, 42 70, -26 70, -26 34))"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0022319-241007104925546/datasets/export for details.
DOI: 10.5281/zenodo.13952212
title: Gemma-Finetune-Review
DOI: 10.5281/zenodo.13952213
title: Gemma-Finetune-Review
DOI: 10.5281/zenodo.13953033
title: Gemma-Finetune-Review
DOI: 10.15468/dl.u5kvhz
title: Occurrence Download

description: A dataset containing 161 species occurrences available in GBIF matching the query:
{
 "and" : [
 {
 "and" : [
 "HasGeospatialIssue is false",
 "HasCoordinate is true",
 "OccurrenceStatus is Present",
 {
 "not" : {
 "BasisOfRecord" : [
 "is one of (Fossil, Living Specimen)"
 ]
 }
 }
 ]
 },
 "TaxonKey is Scutovertex sculptus Michael, 1879",
 "PhylumKey is Arthropoda",
 "Year is greater than or equal to 1992",
 "Year is less than or equal to 2012",
 "Geometry POLYGON((-26 34, 42 34, 42 70, -26 70, -26 34))"
 ]
}

 The dataset includes 161 records from 9 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0022320-241007104925546/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.7n6pbe
title: Occurrence Download

description: A dataset containing 9 species occurrences available in GBIF matching the query:
{
 "and" : [
 {
 "and" : [
 "HasGeospatialIssue is false",
 "HasCoordinate is true",
 "OccurrenceStatus is Present",
 {
 "not" : {
 "BasisOfRecord" : [
 "is one of (Fossil, Living Specimen)"
 ]
 }
 }
 ]
 },
 "TaxonKey is Sphaerochthonius splendidus (Berlese, 1904)",
 "PhylumKey is Arthropoda",
 "Year is greater than or equal to 1992",
 "Year is less than or equal to 2012",
 "Geometry POLYGON((-26 34, 42 34, 42 70, -26 70, -26 34))"
 ]
}

 The dataset includes 9 records from 2 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0022321-241007104925546/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.3jnee9
title: Occurrence Download

description: A dataset containing 27 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Telmatobius laticeps Laurent, 1977"
 ]
}

 The dataset includes 27 records from 10 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0022322-241007104925546/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.ptajaf
title: Occurrence Download

description: A dataset containing 2685 species occurrences available in GBIF matching the query:
{
 "and" : [
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 "TaxonKey is Jarava Ruiz & Pav."
 ]
}

 The dataset includes 2685 records from 135 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0022323-241007104925546/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.29ygu2
title: Occurrence Download

description: A dataset containing 12 species occurrences available in GBIF matching the query:
{
 "and" : [
 {
 "and" : [
 "HasGeospatialIssue is false",
 "HasCoordinate is true",
 "OccurrenceStatus is Present",
 {
 "not" : {
 "BasisOfRecord" : [
 "is one of (Fossil, Living Specimen)"
 ]
 }
 }
 ]
 },
 "TaxonKey is Sphaerozetes orbicularis (Koch, 1835)",
 "PhylumKey is Arthropoda",
 "Year is greater than or equal to 1992",
 "Year is less than or equal to 2012",
 "Geometry POLYGON((-26 34, 42 34, 42 70, -26 70, -26 34))"
 ]
}

 The dataset includes 12 records from 3 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0022324-241007104925546/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.25345/c5057d46j
title: MassIVE MSV000096131 - Jade1 and the HBO1 complex are spatial-selective cofactors of Oct4
title: Oct4 is a master regulator of pluripotency. Potential Oct4 interactors have been cataloged extensively but the manner and significance of these interactions are incompletely defined. Like other POU domain proteins, Oct4 is capable of binding to DNA in multiple configurations, however the relationship between these configurations and cofactor recruitment (and hence transcription output) are unknown. Here, we show that Oct4 interacts with common and unique proteins when bound to DNA in different configurations. One of these proteins is Jade1, a component of the HBO histone acetyltransferase complex. Jade1 preferentially associates with Oct4 when bound to More palindromic Octamer-Related Element (MORE) DNA sequences that bind Oct4 dimers and are associated with strong gene expression. We show that the Oct4 N-terminus is critical for this interaction. ChIP-seq using HBO1, the enzymatic component of the complex, identifies a preference for binding adjacent to Oct4 at MORE sites. Using purified recombinant proteins and nucleosome complexes, we show that the HBO1 complex acetylates histone H3K9 within nucleosomes more efficiently when Oct4 is co-bound to a MORE site. Histone acetylation is further increased when Oct4 is mutated to favor dimeric MORE binding. Cryo-electron microscopy reveals that Oct4 bound to a MORE near the nucleosome entry/exit site partially unwinds DNA from nucleosome core particles, and identifies additional mass associated with the HBO1 complex. These results identify a novel mechanism of transcriptional regulation by Oct4.