cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.11587/aqkwm6/ucvzgf
title: 10701_da02_de_v1_0.tab

description: Core annual data file, imputed data & additional variables (dg8.mz2014j) - STATA format - 226 Variables, 177254 Observations
DOI: 10.11587/p5yj0o/3mvffb
title: 10095_qu_de_v1_0.pdf

description: Questionnaire
DOI: 10.11587/p5yj0o/6dfjee
title: 10095_da_de_v1_0.zsav

description: Core data file - compressed SPSS format - 1585 Variables, 2293 Observations
DOI: 10.11587/p5yj0o/ceaxbm
title: 10095_om_de_v1_0.zip

description: List of variables
DOI: 10.11587/p5yj0o/qekso1
title: 10095_da_de_v1_0.tab

description: Core data file - STATA format - 1585 Variables, 2293 Observations
DOI: 10.11587/p5yj0o/ekrsso
title: 10095_mr_en_v1_0.pdf

description: Method report - English
DOI: 10.25345/c5251fz5k
title: MassIVE MSV000099058 - U2AF regulates the translation and localization of nuclear-encoded mitochondrial mRNAs
title: The mechanisms underlying molecular targeting to mitochondria remain enigmatic, yet this process is crucial for normal cellular function. The RNA binding proteins U2AF1/2 form a heterodimer (U2AF) that shuttles between the nucleus and cytoplasm, regulating splicing in the nucleus and translation in the cytoplasm. Our study identifies an unexpected role for U2AF in mitochondrial function. We demonstrate that U2AF interacts with nuclear-transcribed mitochondrial mRNAs and proteins, inhibits translation, localizes to the mitochondria, and regulates mRNA localization to mitochondria. Moreover, an oncogenic point-mutation in U2AF1(S34F) disrupts this regulation, leading to altered mitochondrial structure, increased translation, and OXPHOS-dependent metabolic rewiring, recapitulating changes observed in bone marrow progenitors from patients with myelodysplastic syndromes. These findings reveal a non-canonical role for U2AF, where it modulates multiple aspects of mitochondrial function by regulating the translation and mitochondrial targeting of nuclear-encoded mRNAs.
DOI: 10.11587/p5yj0o/teno01
title: 10095_da_de_v2_0.zip

description: Core data file - csv, long time archive version - 2497 Variables, 2685 Observations
DOI: 10.11587/p5yj0o/s437wq
title: 10095_da_de_v2_0.tab

description: Core data file - STATA format - 2497 Variables, 2685 Observations
DOI: 10.25345/c5xg9fq2w
title: MassIVE MSV000099059 - Tissue-specific and stimulus-dependent regulation of intron retention in Drosophila head
title: Protein sample preparation Proteins were extracted from 15 Drosophila heads per sample (WT). Heads were homogenized in 10 mM TrisHCl pH7.5, 150 mM NaCl, 2 mM MgCl2, 1% NP40, 0.5% TritonX100, protease and phosphatase inhibitors, 0.5 ul Benzonase, ddH2O. Lysates were incubated at 4C 30 min, centrifuged 10000 rpm 4C 10 min. Supernatant was collected, 5% run on 4-12% BisTris gel and silver stained. Proteins were purified by methanol/chloroform extraction and dried. One WT condition (naive) with 1 replicate, total 3 samples. Digestion and TMT labeling Protein pellets were dissolved in 100 mM TrisHCl pH8.5, 8 M urea. Reduced with 5 mM TCEP 30 min RT, alkylated with 10 mM chloroacetamide 30 min dark. Digested with LysC and trypsin overnight at 37C. Reaction quenched with 5% formic acid. Peptides were purified by C18 SPE, dried, reconstituted in H2O, quantified by colorimetric assay. TEAB added to 100 mM, mixed with iRT standard peptides. TMT6 reagents dissolved in acetonitrile, added to peptide mix, incubated 1 h, quenched with hydroxylamine. Labeling efficiency 85-95%. Labeled peptides were mixed equally, dried, fractionated into 10 parts by high pH cartridges. One multiplex batch (naive) was analyzed as TMT6. LC-MS analysis Label free runs: digested eluates were loaded onto split-triple-phase fused silica microcapillary, analyzed on linear ion trap QE with Agilent 1100 HPLC. 10 step gradient used. Full MS scan 400-1600 m/z followed by 5 data dependent MSMS. Settings: repeat count 2, duration 30 s, exclusion 500, duration 120 s, min threshold 100. TMT runs: analyzed on Orbitrap Fusion Lumos with Dionex Ultimate 3000. Peptides loaded on PepMap C18 trap, separated on in-house packed 50 um id x 150 mm column with 1.9 um C18 resin. Gradient: 50 min equilibration at 2% B, 10 min to 10% B, 180 min 10-40% B, 15 min to 95% B, 15 min wash, reequilibration. Flow 150 nL/min. Orbitrap Fusion settings: MS1 resolution 120000, ITMS2 window 0.7 m/z, inj time 200 ms, CID 35%, SPS ions up to 10, FTMS3 resolution 50000, inj time 105 ms, HCD 65%. MS data processing Label free MSMS searched with ProLuCID against Drosophila protein db. CAM +57 Da static on Cys, oxidation +16 Da on Met. PSMs filtered with DTASelect/Contrast. TMT data processed in Proteome Discoverer 3.1. Spectra searched against Drosophila db with SEQUESTHT. Settings: precursor tolerance 10 ppm, fragment tolerance 0.3 Da, max 2 missed cleavages. Static mods: Cys +57.021 Da, Lys and Nterm +229.1629 Da. Dynamic mod: Met oxidation +15.995 Da. Results filtered at 1% FDR with Percolator. Reporter ion intensities extracted from MS3. Proteins quantified by summing reporter ions. IAF = protein TMT intensity / protein length. IAFw = avg cube root of (1e12 * IAF) / cube root of occurrence of intron retained or spliced genes. FPKMw = avg cube root of (1e12 * FPKM) / cube root of occurrence of related genes.
DOI: 10.11587/p5yj0o/3bvfnk
title: 10095_da_de_v2_0.zsav

description: Core data file - compressed SPSS format - 2497 Variables, 2685 Observations
DOI: 10.11587/p5yj0o/iqpa0k
title: 10095_om_de_v2_0.zip

description: List of Variables
DOI: 10.15468/dl.biztcs
title: Occurrence Download

description: A dataset containing 379 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Vriesea friburgensis Mez"
 ]
}

 The dataset includes 379 records from 61 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0009132-151016162008034/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.n3vso1
title: Occurrence Download

description: A dataset containing 4 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Geometry POLYGON ((-73.3062744140625 5.096415645847096, -73.3062744140625 5.386335689520536, -72.99316406249999 5.386335689520536, -72.99316406249999 5.096415645847096, -73.3062744140625 5.096415645847096))",
 "TaxonKey is Mammalia"
 ]
}

 The dataset includes 4 records from 3 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0009133-170826194755519/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.5ymvpc
title: Occurrence Download

description: A dataset containing 1113 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is South Africa",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 "TaxonKey is Panthera leo (Linnaeus, 1758)"
 ]
}

 The dataset includes 1113 records from 12 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0302267-200613084148143/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.6vuh69
title: Occurrence Download

description: A dataset containing 2 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Corydalis hongbashanensis Lidén & Y.W.Wang"
 ]
}

 The dataset includes 2 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0010663-240314170635999/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.thn8va
title: Occurrence Download

description: A dataset containing 72 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Euploca pallescens (I.M.Johnst.) J.I.M.Melo & Semir"
 ]
}

 The dataset includes 72 records from 28 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0161741-240321170329656/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.3coa5c
title: Occurrence Download

description: A dataset containing 58 species occurrences available in GBIF matching the query:
{
 "and" : [
 {
 "or" : [
 "TaxonKey is Nematoda",
 "TaxonKey is Platyhelminthes",
 "TaxonKey is Mollusca",
 "TaxonKey is Nemertea",
 "TaxonKey is Annelida",
 "TaxonKey is Arthropoda"
 ]
 },
 "Country is Slovenia",
 "Geometry POLYGON((13.733596 45.972151,13.818054 46.074183,13.952636 46.028912,13.870925 45.927751,13.733596 45.972151))"
 ]
}

 The dataset includes 58 records from 4 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0009132-160118175350007/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.f86b7b
title: Occurrence Download

description: A dataset containing 3 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Conophytum devium G.D.Rowley"
 ]
}

 The dataset includes 3 records from 3 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0010659-240314170635999/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.jzw2bs
title: Occurrence Download

description: A dataset containing 19981 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Hemiramphus brasiliensis (Linnaeus, 1758)"
 ]
}

 The dataset includes 19981 records from 90 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0005860-190320150433242/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.xm6inl
title: Occurrence Download

description: A dataset containing 3558 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Salpinctes obsoletus (Say, 1822)",
 "Country is Mexico"
 ]
}

 The dataset includes 3558 records from 50 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0009132-160526112335914/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.eteww8
title: Occurrence Download

description: A dataset containing 12 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Corydalis humosa Migo"
 ]
}

 The dataset includes 12 records from 4 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0010701-240314170635999/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.u4nnag
title: Occurrence Download

description: A dataset containing 232 species occurrences available in GBIF matching the query:
{
 "DatasetKey" : [
 "is Insectos en el municipio de San Juanito, Meta - Colombia BIO"
 ]
}

 The dataset includes 232 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0310453-200613084148143/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.3ngynp
title: Occurrence Download

description: A dataset containing 2443 species occurrences available in GBIF matching the query:
{
 "DatasetKey" : [
 "is Cnidaria MZS"
 ]
}

 The dataset includes 2443 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0009132-160822134323880/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.b49rbf
title: Occurrence Download

description: A dataset containing 5 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Cousinia gigantoptera Rech.fil. & Podlech"
 ]
}

 The dataset includes 5 records from 4 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0010697-240314170635999/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.j5w5ka
title: Occurrence Download

description: A dataset containing 45580 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Monticola saxatilis (Linnaeus, 1766)"
 ]
}

 The dataset includes 45580 records from 378 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0161738-240321170329656/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.r49ptm
title: Occurrence Download

description: A dataset containing 36 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Ruprechtia cruegeri Griseb. ex Lindau"
 ]
}

 The dataset includes 36 records from 15 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0034553-210914110416597/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.8bfcb0
title: Occurrence Download

description: A dataset containing 58 species occurrences available in GBIF matching the query:
{
 "and" : [
 {
 "or" : [
 "TaxonKey is Nematoda",
 "TaxonKey is Platyhelminthes",
 "TaxonKey is Mollusca",
 "TaxonKey is Annelida",
 "TaxonKey is Arthropoda"
 ]
 },
 "Country is Slovenia",
 "Geometry POLYGON((13.733596 45.972151,13.818054 46.074183,13.952636 46.028912,13.870925 45.927751,13.733596 45.972151))"
 ]
}

 The dataset includes 58 records from 4 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0009133-160118175350007/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.cam3pu
title: Occurrence Download

description: A dataset containing 42131 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Geometry POLYGON((268.24219 -10.89844,202.14844 50.27344,29.17969 58.00781,-23.55469 60.82031,-136.75781 54.49219,-100.19531 -15.82031,-79.80469 -48.16406,27.77344 -41.83594,138.16406 -57.30469,271.05469 -53.78906,268.24219 -10.89844))",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "TaxonKey is Albizia Durazz."
 ]
}

 The dataset includes 42131 records from 658 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0036970-210914110416597/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.ng8cxq
title: Occurrence Download

description: A dataset containing 67 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Croton wellensii De Wild."
 ]
}

 The dataset includes 67 records from 11 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0010648-240314170635999/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.iy2twx
title: Occurrence Download

description: A dataset containing 265 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Dendrobium nobile Lindl."
 ]
}

 The dataset includes 265 records from 39 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0009133-160623103540712/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.dd8xm8
title: Occurrence Download

description: A dataset containing 151 species occurrences available in GBIF matching the query:
{
 "and" : [
 "BasisOfRecord is Human Observation",
 "Country is Colombia",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 "TaxonKey is Cebus versicolor Pucheran, 1845"
 ]
}

 The dataset includes 151 records from 9 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0036976-210914110416597/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.wzy4h4
title: Occurrence Download

description: A dataset containing 7 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Corydalis homopetala Diels"
 ]
}

 The dataset includes 7 records from 6 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0010657-240314170635999/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.9zsvej
title: Occurrence Download

description: A dataset containing 345 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Sorbus meinichii (Lindeb.) Hedl.",
 {
 "or" : [
 "BasisOfRecord is Human Observation",
 "BasisOfRecord is Observation",
 "BasisOfRecord is Machine Observation"
 ]
 },
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "Year is greater than or equal to 1970",
 "Year is less than or equal to 2017",
 "DecimalLongitude is greater than or equal to -15",
 "DecimalLongitude is less than or equal to 40",
 "DecimalLatitude is greater than or equal to 30",
 "DecimalLatitude is less than or equal to 75"
 ]
}

 The dataset includes 345 records from 10 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0009133-171124123535762/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.vbue2e
title: Occurrence Download

description: A dataset containing 1703 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is Chile",
 "TaxonKey is Rhinella Fitzinger, 1826"
 ]
}

 The dataset includes 1703 records from 28 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0166943-220831081235567/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.uljk6n
title: Occurrence Download

description: A dataset containing 8 species occurrences available in GBIF matching the query:
{
 "and" : [
 "HasCoordinate is true",
 "TaxonKey is Arthroleptis tuberosus Andersson, 1905",
 "HasGeospatialIssue is false"
 ]
}

 The dataset includes 8 records from 5 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0009133-171219132708484/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.yph26u
title: Occurrence Download

description: A dataset containing 293 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Crassula spathulata Thunb."
 ]
}

 The dataset includes 293 records from 46 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0010704-240314170635999/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.7v6uwr
title: Occurrence Download

description: A dataset containing 2009 species occurrences available in GBIF matching the query:
{
 "and" : [
 "OccurrenceStatus is Present",
 {
 "or" : [
 "TaxonKey is Amazona pretrei (Temminck, 1830)",
 "TaxonKey is Amazona vinacea (Kuhl, 1820)"
 ]
 }
 ]
}

 The dataset includes 2009 records from 48 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0302244-200613084148143/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.5j9av4
title: Occurrence Download

description: A dataset containing 92 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Conophytum ficiforme (Haw.) N.E.Br."
 ]
}

 The dataset includes 92 records from 8 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0010684-240314170635999/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.9ngyh2
title: Occurrence Download

description: A dataset containing 1844 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Otaria flavescens (Shaw, 1800)"
 ]
}

 The dataset includes 1844 records from 39 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0009134-150615163101818/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.agxm4q
title: Occurrence Download

description: A dataset containing 964981 species occurrences available in GBIF matching the query:
{
 "and" : [
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "TaxonKey is Quercus robur L."
 ]
}

 The dataset includes 964981 records from 1081 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0075883-210914110416597/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.an34wq
title: Occurrence Download

description: A dataset containing 3552 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is one of (Germany, Netherlands)",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "TaxonKey is Canis lupus",
 "Year 2015-2025"
 ]
}

 The dataset includes 3552 records from 13 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0014323-251120083545085/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.dg2gey
title: Occurrence Download

description: A dataset containing 15216 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Aphis gossypii"
 ]
}

 The dataset includes 15216 records from 73 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0014322-251120083545085/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.5883/ds-cca1
title: Vizon, C., Lagourgue, L., Payri, C. E., and Nugues, M. M.

description: DNA barcode data hosted in the Data Portal of the Barcode of Life Data Systems. Records consist of specimen metadata, specimen images, and sequence data.
DOI: 10.6084/m9.figshare.30739835.v1
title: Supplemental Data 1 for Busse et al., A thirty year trend of increasing clinical orientation at the National Institutes of Health

description: Mann-Kendall statistics showing trends in R01 and non-R01 award sizes at NIH and separately for a subset of NIH institutes
DOI: 10.25318/1310092301-eng
title: Premature and potentially avoidable mortality, Canada, provinces and territories

description: Number of premature and potentially avoidable deaths and premature and potentially avoidable age-standardized mortality rate, by sex, on an annual basis. Premature deaths are those of individuals who are younger than age 75. Avoidable mortality is defined as "untimely deaths that should not occur in the presence of timely and effective health care, including prevention".
DOI: 10.6084/m9.figshare.30739835
title: Supplemental Data 1 for Busse et al., A thirty year trend of increasing clinical orientation at the National Institutes of Health

description: Mann-Kendall statistics showing trends in R01 and non-R01 award sizes at NIH and separately for a subset of NIH institutes
DOI: 10.5883/ds-llavr
title: L. Lagourgue, F. Rousseau, M. Zubia, C.E. Payri

description: DNA barcode data hosted in the Data Portal of the Barcode of Life Data Systems. Records consist of specimen metadata, specimen images, and sequence data.