cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.20015673
title: Comparison of predicted and covered distances in the incremental shuttle walking test in older adults

description: ABSTRACT Our study aimed to evaluate the external validity of three reference equations for estimating the distance to be covered in the incremental shuttle walking test (ISWT) by older adults and to identify which equation best predicts the distance for this age group. In total, 84 older adults registered in the Health Centers of Diamantina, state of Minas Gerais, Brazil, were selected. The volunteers were subjected to the ISWT and the distance covered, in meters, until the interruption of the test was recorded and compared with the prediction equations. The volunteers had a mean age of 73.15±5.89 years and some health problems common to this age group, were mostly women, and physically active. Statistical analysis showed an interaction between the factors, that is, a difference between the distances covered the ISWT and the distances obtained by the equations. The analysis showed a difference between the men and women (p&lt;0.05) and Equation 1 showed a greater correlation strength (p&lt;0.0001; r=0.414) with the distance covered compared to the other equations. Therefore, our study showed a difference in the comparison of the distances covered and those estimated by three ISWT prediction equations, suggesting that the equations used may overestimate the distance covered by older adults, and that, Equation 1 showed a prediction closer to the distance covered by the older adults of the sample.
DOI: 10.6084/m9.figshare.20015673.v1
title: Comparison of predicted and covered distances in the incremental shuttle walking test in older adults

description: ABSTRACT Our study aimed to evaluate the external validity of three reference equations for estimating the distance to be covered in the incremental shuttle walking test (ISWT) by older adults and to identify which equation best predicts the distance for this age group. In total, 84 older adults registered in the Health Centers of Diamantina, state of Minas Gerais, Brazil, were selected. The volunteers were subjected to the ISWT and the distance covered, in meters, until the interruption of the test was recorded and compared with the prediction equations. The volunteers had a mean age of 73.15±5.89 years and some health problems common to this age group, were mostly women, and physically active. Statistical analysis showed an interaction between the factors, that is, a difference between the distances covered the ISWT and the distances obtained by the equations. The analysis showed a difference between the men and women (p&lt;0.05) and Equation 1 showed a greater correlation strength (p&lt;0.0001; r=0.414) with the distance covered compared to the other equations. Therefore, our study showed a difference in the comparison of the distances covered and those estimated by three ISWT prediction equations, suggesting that the equations used may overestimate the distance covered by older adults, and that, Equation 1 showed a prediction closer to the distance covered by the older adults of the sample.
DOI: 10.6084/m9.figshare.20015675
title: Effect of reaching training combined with electrical stimulation in infants with brachial plexus palsy: a single subject design

description: ABSTRACT This study aimed to evaluate the effect of reaching training combined with functional electrical stimulation (FES) on active upper limb movement in infants with perinatal brachial palsy (PBP). Experimental single-case A-B design with follow-up. Two infants participated in the study, one girl of 7 months and one boy of 10 months of age. Data on infant’s upper limb function (Active Movement Scale) were documented weekly. After six baseline assessments (A), 3 times per 2 weeks, intervention consisted of applying FES Neurodyn® to the deltoid muscle combined with objects reach training, encouraging abduction and anterior shoulder flexion above 90º, for six weeks, totaling 15 visits (B). The infants were reevaluated twice after a period of 15 and 30 days without intervention (follow up). The total score obtained on each evaluation day was plotted graphically. Electrostimulation was well accepted, with no side effects. Both infants showed improvement in the active movement of the affected upper limb after the intervention and the gains were maintained at follow-up, an increase of 9 and 7 points for infants 1 and 2, respectively. Six weeks of intervention resulted in individual changes in infant’s upper limb function, mainly increased active range of motion in shoulder flexion and abduction and elbow flexion. The results of this study suggest the use of electrical stimulation as an adjunct to training the use of the affected upper limb of infants with PBP.
DOI: 10.17028/rd.lboro.19794640
title: Supplementary information files for Assessment of Automated Flow Cytometry Data Analysis Tools within Cell and Gene Therapy Manufacturing

description: Supplementary information files for article Assessment of Automated Flow Cytometry Data Analysis Tools within Cell and Gene Therapy Manufacturing <br> Flow cytometry is widely used within the manufacturing of cell and gene therapies to measure and characterise cells. Conventional manual data analysis relies heavily on operator judgement, presenting a major source of variation that can adversely impact the quality and predictive potential of therapies given to patients. Computational tools have the capacity to minimise operator variation and bias in flow cytometry data analysis; however, in many cases, confidence in these technologies has yet to be fully established mirrored by aspects of regulatory concern. Here, we employed synthetic flow cytometry datasets containing controlled population characteristics of separation, and normal/skew distributions to investigate the accuracy and reproducibility of six cell population identification tools, each of which implement different unsupervised clustering algorithms: Flock2, flowMeans, FlowSOM, PhenoGraph, SPADE3 and SWIFT (density-based, k-means, self-organising map, k-nearest neighbour, deterministic k-means, and model-based clustering, respectively). We found that outputs from software analysing the same reference synthetic dataset vary considerably and accuracy deteriorates as the cluster separation index falls below zero. Consequently, as clusters begin to merge, the flowMeans and Flock2 software platforms struggle to identify target clusters more than other platforms. Moreover, the presence of skewed cell populations resulted in poor performance from SWIFT, though FlowSOM, PhenoGraph and SPADE3 were relatively unaffected in comparison. These findings illustrate how novel flow cytometry synthetic datasets can be utilised to validate a range of automated cell identification methods, leading to enhanced confidence in the data quality of automated cell characterisations and enumerations.
DOI: 10.17028/rd.lboro.19794640.v1
title: Supplementary information files for Assessment of Automated Flow Cytometry Data Analysis Tools within Cell and Gene Therapy Manufacturing

description: Supplementary information files for article Assessment of Automated Flow Cytometry Data Analysis Tools within Cell and Gene Therapy Manufacturing <br> Flow cytometry is widely used within the manufacturing of cell and gene therapies to measure and characterise cells. Conventional manual data analysis relies heavily on operator judgement, presenting a major source of variation that can adversely impact the quality and predictive potential of therapies given to patients. Computational tools have the capacity to minimise operator variation and bias in flow cytometry data analysis; however, in many cases, confidence in these technologies has yet to be fully established mirrored by aspects of regulatory concern. Here, we employed synthetic flow cytometry datasets containing controlled population characteristics of separation, and normal/skew distributions to investigate the accuracy and reproducibility of six cell population identification tools, each of which implement different unsupervised clustering algorithms: Flock2, flowMeans, FlowSOM, PhenoGraph, SPADE3 and SWIFT (density-based, k-means, self-organising map, k-nearest neighbour, deterministic k-means, and model-based clustering, respectively). We found that outputs from software analysing the same reference synthetic dataset vary considerably and accuracy deteriorates as the cluster separation index falls below zero. Consequently, as clusters begin to merge, the flowMeans and Flock2 software platforms struggle to identify target clusters more than other platforms. Moreover, the presence of skewed cell populations resulted in poor performance from SWIFT, though FlowSOM, PhenoGraph and SPADE3 were relatively unaffected in comparison. These findings illustrate how novel flow cytometry synthetic datasets can be utilised to validate a range of automated cell identification methods, leading to enhanced confidence in the data quality of automated cell characterisations and enumerations.
DOI: 10.6084/m9.figshare.20015679
title: Psychomotor, cognitive, and functional variables in healthy older women and older women with Alzheimer’s disease

description: ABSTRACT The Retrogenesis Theory (RT) describes the declines presented in Alzheimer’s disease (AD) based on the stages of Piaget’s neuropsychomotor development. The objective of this cross-sectional study was to evaluate and describe psychomotor and cognitive aspects, falls and the dependency relations between these variables according to RT in healthy older women and with probable Alzheimer’s Disease (AD). Composed of 45 older women (27 healthy and 18 with mild AD), residing in São Paulo from 2016 to 2017. Anamnesis, Geriatric Depression Scale Yesavage (GDS-30), Montreal Cognitive Assessment (MoCA), Cambridge were used for evaluation Revised Cognitive Exam (CAMCOG-R), Berg Balance Scale (BBS), timed up and go test (TUGT) and Direct Functional Status Assessment (DAFS-BR). The Mann-Whitney U tests, Spearman correlation and multiple regression analysis were used with p &lt;0.05. A loss order similar to that suggested by RT was observed in both groups. The lower the CAMCOG-R index, the greater the number of falls (p=0.03). Praxia items (p&lt;0.00) and executive functions (p&lt;0.00) of CAMCOG-R highly correlated with TUGT and BBS. A dependency relation between functionality/cognition is suggested; balance/cognition and correlation between risk of falling and cognitive performance in both groups. The observed losses are in line with what the RT proposes, but with different intensities between the groups. Longitudinal studies are necessary, with the use of imaging tests to validate RT in the loss patterns in older people with and without AD.
DOI: 10.6084/m9.figshare.20015679.v1
title: Psychomotor, cognitive, and functional variables in healthy older women and older women with Alzheimer’s disease

description: ABSTRACT The Retrogenesis Theory (RT) describes the declines presented in Alzheimer’s disease (AD) based on the stages of Piaget’s neuropsychomotor development. The objective of this cross-sectional study was to evaluate and describe psychomotor and cognitive aspects, falls and the dependency relations between these variables according to RT in healthy older women and with probable Alzheimer’s Disease (AD). Composed of 45 older women (27 healthy and 18 with mild AD), residing in São Paulo from 2016 to 2017. Anamnesis, Geriatric Depression Scale Yesavage (GDS-30), Montreal Cognitive Assessment (MoCA), Cambridge were used for evaluation Revised Cognitive Exam (CAMCOG-R), Berg Balance Scale (BBS), timed up and go test (TUGT) and Direct Functional Status Assessment (DAFS-BR). The Mann-Whitney U tests, Spearman correlation and multiple regression analysis were used with p &lt;0.05. A loss order similar to that suggested by RT was observed in both groups. The lower the CAMCOG-R index, the greater the number of falls (p=0.03). Praxia items (p&lt;0.00) and executive functions (p&lt;0.00) of CAMCOG-R highly correlated with TUGT and BBS. A dependency relation between functionality/cognition is suggested; balance/cognition and correlation between risk of falling and cognitive performance in both groups. The observed losses are in line with what the RT proposes, but with different intensities between the groups. Longitudinal studies are necessary, with the use of imaging tests to validate RT in the loss patterns in older people with and without AD.
DOI: 10.5281/zenodo.6406393
title: Molecule dataset used in workflow memoization experiments

description: The dataset contains 80 molecules in Simplified Molecular Input Line Entry System (SMILES) format.
DOI: 10.5281/zenodo.6406392
title: Molecule dataset used in workflow memoization experiments

description: The dataset contains 80 molecules in Simplified Molecular Input Line Entry System (SMILES) format.
DOI: 10.6084/m9.figshare.20015682
title: Profile of scientific academic background and production of researcher physical therapists in Brazil

description: ABSTRACT To evaluate the academic background and scientific productions’ profile of researcher physiotherapists in Brazil. The study was cross-sectional in design and performed by analyzing the professional resumes that have been updated within the last 5 years in the Lattes Platform of the Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq). The main variables analyzed were sex, geographical distribution, kind of undergraduate institution, working location, complementary training, scientific production, and participation in events. The analysis was carried out on 17,864 curricula which were within the selection criteria, out of a total of 47,741. There was a predominance of female therapists (75.5%) and therapists from the southeast region (35%). Most have completed their undergraduate degree in private institutions (75%) and graduate programs (61.4%), and work at universities (30%). Males perform better (p&lt;0.001) in scientific productions, participation in events, and complementary training activities. Graduates from public institutions have more scientific productions, events, and complementary training activities (p&lt;0.001). However, professionals that have completed their undergraduate degree in private institutions do graduate programs the most (p=0.05). Most researcher physical therapists in Brazil are females, have completed their undergraduate degrees in the Southeast region and in private institutions, have completed graduate programs and work in universities. Despite the female predominance, male professionals and those therapists who have completed their undergraduate degree from public institutions have a greater amount of scientific productions, participation in events and complementary degrees.
DOI: 10.6084/m9.figshare.20015682.v1
title: Profile of scientific academic background and production of researcher physical therapists in Brazil

description: ABSTRACT To evaluate the academic background and scientific productions’ profile of researcher physiotherapists in Brazil. The study was cross-sectional in design and performed by analyzing the professional resumes that have been updated within the last 5 years in the Lattes Platform of the Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq). The main variables analyzed were sex, geographical distribution, kind of undergraduate institution, working location, complementary training, scientific production, and participation in events. The analysis was carried out on 17,864 curricula which were within the selection criteria, out of a total of 47,741. There was a predominance of female therapists (75.5%) and therapists from the southeast region (35%). Most have completed their undergraduate degree in private institutions (75%) and graduate programs (61.4%), and work at universities (30%). Males perform better (p&lt;0.001) in scientific productions, participation in events, and complementary training activities. Graduates from public institutions have more scientific productions, events, and complementary training activities (p&lt;0.001). However, professionals that have completed their undergraduate degree in private institutions do graduate programs the most (p=0.05). Most researcher physical therapists in Brazil are females, have completed their undergraduate degrees in the Southeast region and in private institutions, have completed graduate programs and work in universities. Despite the female predominance, male professionals and those therapists who have completed their undergraduate degree from public institutions have a greater amount of scientific productions, participation in events and complementary degrees.
DOI: 10.6084/m9.figshare.20015684
title: Motor Competence Assessment - cultural adaptation for Brazil (MCA-BR)

description: ABSTRACT We adapted the Motor Competence Assessment (MCA) to Brazilian Portuguese. Two professionals proficient in Brazilian Portuguese independently translated the MCA into the Portuguese language (T1 and T2). Then, the translated version of consensus (TU) was generated. Two translators performed two back-translations in European Portuguese (BT1 and BT2) of the TU version. A new consensus process between translators and researchers resulted in a European Portuguese version (BTfinal), which was compared to the original version in search of possible semantic differences. A committee of experts, composed of a physical therapist and two physical educators to verify the content, reviewed the version of the instrument in Brazilian Portuguese (TU), called “Avaliação da Competência Motora,” which generated the second version of agreement (Tfinal). We sent the Tfinal to one of the authors of the original evaluation to verify the relevance of the Brazilian Portuguese version. After this step, 20 physical therapists and 20 physical educators verified the applicability of the evaluation model. The MCA was then culturally adapted for Brazil. It is a relevant instrument as it evaluates motor competence without age limit, and can assist in monitoring the motor development of individuals.
DOI: 10.6084/m9.figshare.20015684.v1
title: Motor Competence Assessment - cultural adaptation for Brazil (MCA-BR)

description: ABSTRACT We adapted the Motor Competence Assessment (MCA) to Brazilian Portuguese. Two professionals proficient in Brazilian Portuguese independently translated the MCA into the Portuguese language (T1 and T2). Then, the translated version of consensus (TU) was generated. Two translators performed two back-translations in European Portuguese (BT1 and BT2) of the TU version. A new consensus process between translators and researchers resulted in a European Portuguese version (BTfinal), which was compared to the original version in search of possible semantic differences. A committee of experts, composed of a physical therapist and two physical educators to verify the content, reviewed the version of the instrument in Brazilian Portuguese (TU), called “Avaliação da Competência Motora,” which generated the second version of agreement (Tfinal). We sent the Tfinal to one of the authors of the original evaluation to verify the relevance of the Brazilian Portuguese version. After this step, 20 physical therapists and 20 physical educators verified the applicability of the evaluation model. The MCA was then culturally adapted for Brazil. It is a relevant instrument as it evaluates motor competence without age limit, and can assist in monitoring the motor development of individuals.
DOI: 10.6084/m9.figshare.20015691
title: Predictors of mobility impairment after hospitalization in a reference hospital among individuals with infectious diseases

description: ABSTRACT Infectious diseases may lead to motor and functional complications, impairing the quality of life of affected individuals. Moreover, hospitalization itself is considered an important cause of functional decline in patients. In these cases, physiotherapy aims to preserve and restore the integrity of organs and functions, promoting the maintenance of range of motion, the gain of muscle strength, the training of postural changes and gait, as well as the practice of aerobic exercises and the improvement of thoracic expandability in hospitalized individuals. This study aimed to describe the epidemiological profile of patients at a reference hospital for infectious diseases and identify predictors of mobility impairment after hospitalization This is a retrospective study based on the analysis of medical records of patients hospitalized in 2016 who required physiotherapy. Data consisted of socioeconomic and clinical variables, and the predictors of mobility impairment after hospitalization were determined by descriptive statistics and binary logistic regression. Among the 638 electronic medical records of patients hospitalized from January to December 2016 who required physiotherapy, 66.6% were men with median age of 42 years and 50.8% were HIV-positive. We verified five risk factors for mobility impairment after hospitalization: age, number of previous hospitalizations, use of mechanical ventilation, HIV-infected patients, and presence of opportunistic infections. Our findings point to the importance of physiotherapy for improving functional mobility in hospitalized patients.
DOI: 10.6084/m9.figshare.20015691.v1
title: Predictors of mobility impairment after hospitalization in a reference hospital among individuals with infectious diseases

description: ABSTRACT Infectious diseases may lead to motor and functional complications, impairing the quality of life of affected individuals. Moreover, hospitalization itself is considered an important cause of functional decline in patients. In these cases, physiotherapy aims to preserve and restore the integrity of organs and functions, promoting the maintenance of range of motion, the gain of muscle strength, the training of postural changes and gait, as well as the practice of aerobic exercises and the improvement of thoracic expandability in hospitalized individuals. This study aimed to describe the epidemiological profile of patients at a reference hospital for infectious diseases and identify predictors of mobility impairment after hospitalization This is a retrospective study based on the analysis of medical records of patients hospitalized in 2016 who required physiotherapy. Data consisted of socioeconomic and clinical variables, and the predictors of mobility impairment after hospitalization were determined by descriptive statistics and binary logistic regression. Among the 638 electronic medical records of patients hospitalized from January to December 2016 who required physiotherapy, 66.6% were men with median age of 42 years and 50.8% were HIV-positive. We verified five risk factors for mobility impairment after hospitalization: age, number of previous hospitalizations, use of mechanical ventilation, HIV-infected patients, and presence of opportunistic infections. Our findings point to the importance of physiotherapy for improving functional mobility in hospitalized patients.