cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.7792022.v2
title: Autophagy-mediated <i>Mir6981</i> degradation exhibits <i>CDKN1B</i> promotion of PHLPP1 protein translation

description: PHLPP1 (PH domain and leucine rich repeat protein phosphatase 1) is a newly identified family of Ser/Thr phosphatases that catalyzes the dephosphorylation of a conserved regulatory motif of the AGC kinases resulting in a tumor suppressive function, while CDKN1B/p27 also acts as a tumor suppressor by regulating cell cycle, senescence, apoptosis, and cell motility. Our most recent studies reveal that CDKN1B is required for PHLPP1 abundance, which contributes to the inhibition of carcinogenic arsenite-induced cell malignant transformation through inhibition of RPS6-mediated <i>Hif1a</i> translation. However, nothing is known about the mechanisms underlying the crosstalk between these 2 key tumor suppressors in intact cells. Here, for the first time to the best of our knowledge, we show that CDKN1B is able to promote PHLPP1 protein translation by attenuating the abundance of <i>Mir6981</i>, which binds directly to the 5ʹuntranslated region (UTR) of <i>Phlpp1</i> mRNA. Further studies indicate that the attenuation of <i>Mir6981</i> expression is due to macroautophagy/autophagy-mediated degradation of <i>Mir6981</i> in an SQSTM1/p62-dependent fashion. Moreover, we have determined that <i>Sqstm1</i> is upregulated by CDKN1B at the level of transcription <i>via</i> enhancing SP1 protein stability in an HSP90-depdendent manner. Collectively, our studies prove that: 1) SQSTM1 is a CDKN1B downstream effector responsible for CDKN1B-mediated autophagy; 2) by promoting the autophagy-mediated degradation of <i>Mir6981</i>, CDKN1B exerts a positive regulatory effect on PHLPP1 translation; 3) <i>Mir6981</i> suppresses PHLPP1 translation by binding directly to its mRNA 5ʹ-UTR, rather than classical binding to the 3ʹ-UTR. These findings provide significant insight into understanding the crosstalk between CDKN1B and PHLPP1. <b>Abbreviations:</b> ATG: autophagy related; ACTB: actin beta; BAF: bafilomycin; BECN1: beclin 1; <i>Cdkn1b</i>/<i>p27</i>: cyclin-dependent kinase inhibitor 1B; CHX: cycloheximide; DMEM: dulbecco’s modified eagle medium; FBS: fetal bovine serum; GAPDH: glyceraldehyde −3-phosphate dehydrogenase; <i>Hif1a</i>: hypoxia inducible factor 1, alpha subunit; <i>Hsp90</i>: heat shock protein 90; JUN: Jun proto-oncogene, AP1 transcription factor subunit; MAP1LC3/LC3: microtubule-associated protein 1 light chain 3; MG132: proteasome inhibitor; <i>Mtor</i>: mechanistic target of rapamycin kinase; <i>Phlpp1</i>: PH domain and leucine rich repeat protein phosphatase 1; <i>Phlpp2</i>: PH domain and leucine rich repeat protein phosphatase 2; <i>Pp2c</i>: protein phosphatase 2 C; RPS6: ribosomal protein S6; <i>Sp1</i>: trans-acting transcription factor 1; <i>Sqstm1/p62</i>: sequestosome 1; TUBA: alpha tubulin; 3ʹ-UTR; 3ʹ-untranslated region; 5ʹ-UTR: 5ʹ-untranslated region.
DOI: 10.6084/m9.figshare.7792022.v1
title: Autophagy-Mediated <i>Mir6981</i> Degradation Exhibits <i>Cdkn1b</i> Promotion of PHLPP1 Protein Translation

description: PHLPP1 (PH domain and leucine rich repeat protein phosphatase 1) is a newly identified family of Ser/Thr phosphatases that catalyzes the dephosphorylation of a conserved regulatory motif of the AGC kinases resulting in a tumor suppressive function, while CDKN1B/p27 also acts as a tumor suppressor by regulating cell cycle, senescence, apoptosis, and cell motility. Our most recent studies reveal that CDKN1B is required for PHLPP1 abundance, which contributes to the inhibition of carcinogenic arsenite-induced cell malignant transformation through inhibition of RPS6-mediated <i>Hif1a</i> translation. However, nothing is known about the mechanisms underlying the crosstalk between these 2 key tumor suppressors in intact cells. Here, for the first time to the best of our knowledge, we show that CDKN1B is able to promote PHLPP1 protein translation by attenuating the abundance of <i>Mir6981</i>, which binds directly to the 5ʹuntranslated region (UTR) of <i>Phlpp1</i> mRNA. Further studies indicate that the attenuation of <i>Mir6981</i> expression is due to macroautophagy/autophagy-mediated degradation of <i>Mir6981</i> in an SQSTM1/p62-dependent fashion. Moreover, we have determined that <i>Sqstm1</i> is upregulated by CDKN1B at the level of transcription <i>via</i> enhancing SP1 protein stability in an HSP90-depdendent manner. Collectively, our studies prove that: 1) SQSTM1 is a CDKN1B downstream effector responsible for CDKN1B-mediated autophagy; 2) by promoting the autophagy-mediated degradation of <i>Mir6981</i>, CDKN1B exerts a positive regulatory effect on PHLPP1 translation; 3) <i>Mir6981</i> suppresses PHLPP1 translation by binding directly to its mRNA 5ʹ-UTR, rather than classical binding to the 3ʹ-UTR. These findings provide significant insight into understanding the crosstalk between CDKN1B and PHLPP1.
DOI: 10.6084/m9.figshare.8840600
title: Additional file 3: of Transcriptomic analysis of differentially expressed genes in the oviduct of Rhacophorus omeimontis provides insights into foam nest construction

description: The Perl scripts for transcriptome analysis in this study. (ZIP 5 kb)
DOI: 10.6084/m9.figshare.8840600.v1
title: Additional file 3: of Transcriptomic analysis of differentially expressed genes in the oviduct of Rhacophorus omeimontis provides insights into foam nest construction

description: The Perl scripts for transcriptome analysis in this study. (ZIP 5 kb)
DOI: 10.25625/q7tcis
title: Replication Data for: "Disentangling the multiorbital contributions of excitons by photoemission exciton tomography"

description: This dataset contains the data and analysis scripts to for the publication "Disentangling the multiorbital contributions of excitons by photoemission exciton tomography", Nat Commun 15, 1804 (2024)
DOI: 10.6084/m9.figshare.8316326.v1
title: The scrub typhus in mainland China: spatiotemporal expansion and risk prediction underpinned by complex factors

description: In mainland China, a geographic northward expansion of scrub typhus has been seen, highlighting the need to understand the factors and identify the risk for disease prevention. Incidence data from 1980 to 2013 were used. A Cox proportional hazard model was used to identify drivers for spatial spread, and a boosted regression tree (BRT) model was constructed to predict potential risk areas. Since the 1980s, an invasive expansion from South Natural Foci towards North Natural Foci was clearly identified, with the epidemiological heterogeneity observed between two regions, mainly in spatial distribution, seasonality, and demographic characteristics. Survival analysis disclosed significant factors contributing to the spatial expansion as following: being intersected by freeway (HR = 1.31, 95% CI: 1.11–1.54), coverage percentage of broadleaf forest (HR = 1.10, 95% CI: 1.06–1.15), and monthly average temperature (HR = 1.27, 95% CI: 1.25–1.30). The BRT models showed that precipitation, sunshine hour, temperature, crop field, and relative humidity contributed substantially to the spatial distribution of scrub typhus. A county-scale risk map was created to predict the regions with high probability of the disease. The current study enabled a comprehensive overview of epidemiological characteristics of scrub typhus in mainland China.
DOI: 10.48597/4pzs-hc5s
title: Measurement of Heavy metals at Knokke

description: Measurement of Heavy metals at Knokke
DOI: 10.48597/4u4r-khbz
title: Measurement of Heavy metals at Bredene

description: Measurement of Heavy metals at Bredene
DOI: 10.48597/5upt-g47b
title: Measurement of Inorganics in precipitation at Brugge

description: Measurement of Inorganics in precipitation at Brugge
DOI: 10.48597/5vd2-zmwk
title: Measurement of Heavy metals at Ulborg

description: Measurement of Heavy metals at Ulborg
DOI: 10.48597/6zdp-8txs
title: Measurement of Heavy metals at Ulborg

description: Measurement of Heavy metals at Ulborg
DOI: 10.34740/kaggle/dsv/7717375
title: Renewable Energy Worldwide Dec2023-Feb2024
DOI: 10.34808/kr0g-yq59
title: Poland’s energy dependence - economic context

description: Poland does not have vast resources of non-renewable energy and no nuclear power plant, therefore the issue of the energy dependence of the state, which affects the level of energy security of the country, is an extremely important factor. It depends on both the volume of imports of energy raw materials and the policy of diversification of sources of supply regarding this type of raw materials. Energy infrastructure, which allows for the transmission, distribution and storage of raw materials and energy, is of great importance in terms of security.  The following dataset presents Poland's dependence on raw materials from foreign partners - in the field of imports of electricity, natural gas, crude oil, non-renewable energy resources, i.e., hard coal and lignite, and the country’s dynamics in the amount of imports. The second part of the dataset shows the dynamics of exports of energy resources in Poland.
DOI: 10.6084/m9.figshare.7792061
title: Genetic analysis of a recently established <i>Undaria pinnatifida</i> (Laminariales: Alariaceae) population in the northern Wadden Sea reveals close proximity between drifting thalli and the attached population

description: <i>Undaria pinnatifida</i>, a kelp species native to East Asia, has become cosmopolitan and drawn increasing attention due to its worldwide spread in recent decades. Floating fragments of this alga were found washed ashore on Sylt in 2016, the first record of this species in Germany. Thalli attached to local oyster reefs were detected in 2017. The genetic relationship between the floating and attached thalli on Sylt, as well as their relevance to the populations from northern Europe and native regions, was hitherto unknown. Here, 10 microsatellite markers were used to assess relationships between the recently established population on Sylt and five other northern European populations in France (Brittany, West English Channel), the Netherlands and England (Plymouth, West English Channel) plus three natural populations in China. Almost no genetic differentiation was detected between the floating and attached populations on Sylt, but they were genetically distinct from all the other studied northern European populations. The very low genetic diversity revealed in the new founder populations of Sylt suggests that they came from genetically similar parents. The marked reduction in both the number of alleles and heterozygosity in the northern European populations, as compared with the Chinese ones, is typical of founder effects in recently populated regions. Prominent genetic divergence was found between most of the northern European populations except those within Brittany and Sylt. Further studies will focus on identifying the putative source populations that might be found on shellfish farms, in local marinas or the benthic habitats around Sylt Island.
DOI: 10.6084/m9.figshare.7792061.v1
title: Genetic analysis of a recently established <i>Undaria pinnatifida</i> (Laminariales: Alariaceae) population in the northern Wadden Sea reveals close proximity between drifting thalli and the attached population

description: <i>Undaria pinnatifida</i>, a kelp species native to East Asia, has become cosmopolitan and drawn increasing attention due to its worldwide spread in recent decades. Floating fragments of this alga were found washed ashore on Sylt in 2016, the first record of this species in Germany. Thalli attached to local oyster reefs were detected in 2017. The genetic relationship between the floating and attached thalli on Sylt, as well as their relevance to the populations from northern Europe and native regions, was hitherto unknown. Here, 10 microsatellite markers were used to assess relationships between the recently established population on Sylt and five other northern European populations in France (Brittany, West English Channel), the Netherlands and England (Plymouth, West English Channel) plus three natural populations in China. Almost no genetic differentiation was detected between the floating and attached populations on Sylt, but they were genetically distinct from all the other studied northern European populations. The very low genetic diversity revealed in the new founder populations of Sylt suggests that they came from genetically similar parents. The marked reduction in both the number of alleles and heterozygosity in the northern European populations, as compared with the Chinese ones, is typical of founder effects in recently populated regions. Prominent genetic divergence was found between most of the northern European populations except those within Brittany and Sylt. Further studies will focus on identifying the putative source populations that might be found on shellfish farms, in local marinas or the benthic habitats around Sylt Island.
DOI: 10.15468/gbpj5k
title: Macrozoobenthos, National Monitoring Study 2019, EMBLAS Plus Project, EMBLAS Plus Project

description: Macrozoobenthos data: species composition, abundance (ind/m²), biomass (g/m²) collected during the National Monitoring Study (NMS_UA 2019) in the Ukrainian waters (North-Western part of the Black Sea) onboard the Vessel “Auguste Piccard”, (Ukraine) in August-October 2019
DOI: 10.15468/3hgdg9
title: 2021_NATURALIA_1

description: 2021_NATURALIA_ESCOTA-SNCF:NATURALIA
DOI: 10.15468/6rrdsd
title: VNF- DTS- Dragage d'entretien des abords de l’écluse secondaire à Niffer - Poissons - Inventaire non protocolé

description: Liste des poissons observés dans le cadre des prospections de terrain réalisées au niveau de l'aire d'étude du projet de parc photovoltaïque à Niffer (68)
DOI: 10.15468/xujk4k
title: Suivi post-implantation du parc éolien de Lacombe en 2018 / 2019

description: Suivi de la mortalité des oiseaux et des chauves-souris Suivi en continu de l'activité des chiroptères à hauteur de nacelle
DOI: 10.15468/557xj6
title: [SUIVI] Parc éolien Bois de Montrigaud 2019 à 2022-BDM Suivi d'activité 2019 E3

description: Suivi d'activité 2019 en nacelle de l'éolienne E3 pour le parc de Bois de Montrigaud
DOI: 10.15468/ck46ne
title: 2020_SOPTOM_1

description: 2020_SOPTOM_CMR:SOPTOM / données fournies par SOPTOM en 2020
DOI: 10.15468/bg7xha
title: Parc éolien d'Orvilliers Saint Julien - Suivi mortalité chiroptères 2019 parc éolien Orvilliers

description: Suivi de la mortalité des Chiroptères en 2019 sur le parc éolien d'Orvilliers Saint Julien
DOI: 10.6084/m9.figshare.20374995
title: What Are the Users’ Needs? Design of a User-Centered Explainable Artificial Intelligence Diagnostic System

description: The application of artificial intelligence (AI) systems has surged in the high-risk area of medicine, and these systems must explain their decisions to different users. However, existing explainable AI (XAI) design practices in the medical domain are mostly focused on domain experts, such as physicians, and there is a lack of XAI design practices for consumer users. Therefore, we developed a library of XAI user needs in the medical domain, which can be used as an auxiliary tool for the development of user-centered XAI design solutions in this domain. Moreover, through empirical research, based on our XAI user Needs Library, we designed an XAI-based electrocardiogram diagnostic system prototype for consumer users and conducted a user evaluation. The results provide the empirical experience of the design space of XAI and promote consumer user-centered XAI practices.
DOI: 10.15468/n9wbj9
title: Centrale éolienne de Dainville

description: Le parc éolien de Dainville, situé sur la commune de Dainville-Bertheléville dans le département de la Meuse (55) en région Grand-Est. Le parc éolien de Dainville a une puissance de 24 MW, est constitué de 12 éoliennes Vestas V110/95m.
DOI: 10.15468/tu3pwy
title: 2020_Parc National de Port Cros_8

description: 2020_PNPC_LPO:Parc National de Port Cros
DOI: 10.34808/6fjr-0c16
title: Entrepreneurs' intention to use tax relief

description: The dataset presents the results of research conducted by the author among Polish entrepreneurs in 2017–2020. The diagnostic survey method was used to collect primary data among enterprises from the SME sector. The measurement instrument was a survey questionnaire developed by the author. This study is a key piece of research. The aim was to examine enterprises that meet the EU definition in the field of micro, small and medium-sized entities, based in the territory of the Republic of Poland, income tax payers (CIT or PIT), from various industries and sectors.The main study included two stages - a study using a questionnaire and a study using an interview sheet. The actual survey was anonymous and consisted of  questions that were grouped into thematic domains consistent with the formulated research problems:• intentions to use tax breaks;• advantage of EU reliefs over reliefs and exemptions in Poland;• the desired direction of changes in the field of innovation relief in Poland;• the desired direction of changes in the field of development relief;• attractiveness of income tax preferences from the point of view of running a business;• knowledge about reliefs and exemptions in the applicable legal regime;• barriers in the system of reliefs and exemptions;• preferred facilities for using reliefs and exemptions;• preferences regarding reliefs and exemptions in the context of reliefs applicable in the European Union.The answers to the questions were formulated in the form of a cafeteria, i.e. a list of possible answers to closed questions.
DOI: 10.15468/bjm4fw
title: 2020_Réserve Naturelle de Camargue_1

description: 2020_RNN-Camargue_entomo:Réserve Naturelle de Camargue
DOI: 10.15468/djury3
title: Parc éolien de Pays d'Othe-Pays d'Othe Mortalité Avifaune 2019

description: Suivi environnemental - Mai à octobre 2019 - Données brutes mortalité avifaune
DOI: 10.15468/yntypr
title: Parc éolien de Saint-Ambroix Est - Chiroptère SM3

description: Chiroptère SM3 / Le projet du parc éolien de Saint-Ambroix Est est composé de 3 aérogénérateurs. Une étude d’impact sur l’environnement a été réalisée afin d’évaluer les enjeux environnementaux liés au projet et a permis de rechercher, en amont, les mesures à mettre en place pour la protection de l'environnement et l’insertion du projet.
DOI: 10.15468/gfvhgs
title: 2021_Entomia_1

description: 2021_Entomia:Entomia / données fournies par Entomia en 2021
DOI: 10.15468/8nnv53
title: SMNG_Myriapoda_Waldklimafonds 2018/19

description: This dataset is part of Edaphobase. Edaphobase is a data warehouse that collects information from literature, museum collections and research data about the distribution and ecology of soil organisms (earthworms, potworms, nematodes, springtails, proturans, diplurans, moss/beetle mites, gamasina mites, centipedes, millipedes, woodlice, soil fungi and soil prokaryotes). You can discover the whole Edaphobase data here: https://portal.edaphobase.org/ To get more information about Edaphobase please go to: https://edaphobase.org/ Discover the datahttps://portal.edaphobase.org/?qxenv:action:gbif&qxenv:sources:278832
DOI: 10.15468/brngtf
title: Parc éolien El Singla (66) - Suivi de la mortalité sous les éoliennes (chiroptères) en 2018-2019

description: Le parc éolien a fait l'objet d'un suivi de mortalité sous les 9 éoliennes du parc en 2018-2019 par le bureau d'études ABIES.
DOI: 10.15468/wt3y2y
title: Renouvellement de l'autorisation d'exploiter de la carrière de Villiers-sur-Seine-Inventaire avifaune

description: Inventaire non standardisé
DOI: 10.15468/qbt7pu
title: Parc éolien Mont de la Grévière 2021 - Mont de la Grévière - suivi post implantation de parc éoliens - 2021

description: Suivi postimplantation de parc éolien
DOI: 10.48597/7ma3-v9qg
title: Measurement of Precipitation_amount_off at De Zilk

description: Measurement of Precipitation_amount_off at De Zilk
DOI: 10.48597/7pye-jws4
title: Measurement of Aerosol light scattering at Boulder Table Mountain

description: Measurement of Aerosol light scattering at Boulder Table Mountain
DOI: 10.48597/8m2d-sfkk
title: Measurement of Heavy metals at Westerland

description: Measurement of Heavy metals at Westerland
DOI: 10.48597/8pjx-kvs7
title: Measurement of Precipitation_amount at Zingst

description: Measurement of Precipitation_amount at Zingst
DOI: 10.15468/c59cp5
title: LABRUGUIERE ENERGIE_SUIVIS ENVIRONNEMENTAUX_2019 - LABRUGUIERE ENERGIE - suivi mortalité 2019

description: Données du suivi mortalité mené en 2019 sur le parc éolien de Labruguière Energie
DOI: 10.15468/u35zhu
title: [SUIVI] Suivi réglementaire du Parc éolien de Rosière - Mortalité

description: [SUIVI] Suivi réglementaire du Parc éolien de Rosière - Mortalité 2019
DOI: 10.15468/pkm42r
title: Projet éolien de la Haute-Voie (51) - Parc éolien de La Haute-Voie - inventaires chiroptères au sol

description: Inventaire des chiroptères au sol réalisé lors de l'étude d'impact en 2018-2019
DOI: 10.15468/vjufc5
title: 2020_Alain SADORGE_1

description: 2020_SADORGE:Alain SADORGE
DOI: 10.6084/m9.figshare.7792103
title: Comparative transcriptome profiling of <i>Kappaphycus alvarezii</i> (Rhodophyta, Gigartinales) in response to two extreme temperature treatments: an RNA-seq-based resource for photosynthesis research

description: <i>Kappaphycus alvarezii</i> provides an important raw material for the extraction of κ-carrageenan. Comparative transcriptome analysis of <i>K. alvarezii</i> after 24 h extreme temperature treatments (17°C and 34°C) was performed to uncover the molecular mechanisms controlling temperature-related photosynthesis regulation. Optimum temperature (28°C) was employed as the control. After <i>de novo</i> assembly of these three transcriptome samples and searching the assembled transcripts by BLAST against the NCBI nr databases, 11,537 top-hit transcripts were assigned as unigenes. Through comparisons, 302 significantly differentially expressed genes were identified. Twenty-three of the differentially expressed unigenes encoded photosystem antenna protein subunits and a further 25 were associated more broadly with photosynthesis functions. Compared to the light-harvesting complex (LHC) protein, the expression of phycobiliproteins (PBPs) was stable after extreme low and high temperature (ELT/EHT) treatments. Both ELT and EHT were found to inhibit the expression of subunits of photosystem II (PsbA, PsbC, Psb27, PsbW, PsbS), photosystem I (PsaF, PsaG, PsaK) and photosynthetic electron transport (PetE). These results were confirmed through targeted analysis of the mRNA and protein abundance of individual proteins, and were congruent with the results of chlorophyll <i>a</i> fluorescence (OJIP) measurements performed with temperature-stressed lines. In conclusion, similarities and differences in the behaviours of photosynthesis-related genes were summarized to provide opportunities for understanding the responses of <i>K. alvarezii</i> after extreme temperature treatments.
DOI: 10.15468/vt4cg8
title: Parc éolien de Courdemanges-chiro

description: chiro / Le projet de parc éolien de Courdemanges comprendra 4 aérogénérateurs d’une puissance nominale maximale de 5,5 MW et d'une hauteur maximale de 180 mètres en bout de pale.