cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.1627950
title: A Dynamic Bayesian Model for Characterizing Cross-Neuronal Interactions During Decision-Making

description: The goal of this article is to develop a novel statistical model for studying cross-neuronal spike train interactions during decision-making. For an individual to successfully complete the task of decision-making, a number of temporally organized events must occur: stimuli must be detected, potential outcomes must be evaluated, behaviors must be executed or inhibited, and outcomes (such as reward or no-reward) must be experienced. Due to the complexity of this process, it is likely the case that decision-making is encoded by the temporally precise interactions between large populations of neurons. Most existing statistical models, however, are inadequate for analyzing such a phenomenon because they provide only an aggregated measure of interactions over time. To address this considerable limitation, we propose a dynamic Bayesian model that captures the time-varying nature of neuronal activity (such as the time-varying strength of the interactions between neurons). The proposed method yielded results that reveal new insight into the dynamic nature of population coding in the prefrontal cortex during decision-making. In our analysis, we note that while some neurons in the prefrontal cortex do not synchronize their firing activity until the presence of a reward, a different set of neurons synchronizes their activity shortly after stimulus onset. These differentially synchronizing subpopulations of neurons suggest a continuum of population representation of the reward-seeking task. Second, our analyses also suggest that the degree of synchronization differs between the rewarded and nonrewarded conditions. Moreover, the proposed model is scalable to handle data on many simultaneously recorded neurons and is applicable to analyzing other types of multivariate time series data with latent structure. Supplementary materials (including computer codes) for our article are available online.
DOI: 10.6084/m9.figshare.1627950.v1
title: A Dynamic Bayesian Model for Characterizing Cross-Neuronal Interactions During Decision Making

description: The goal of this paper is to develop a novel statistical model for studying cross-neuronal spike train interactions during decision making. For an individual to successfully complete the task of decision-making, a number of temporally-organized events must occur: stimuli must be detected, potential outcomes must be evaluated, behaviors must be executed or inhibited, and outcomes (such as reward or no-reward) must be experienced. Due to the complexity of this process, it is likely the case that decision-making is encoded by the temporally-precise interactions between large populations of neurons. Most existing statistical models, however, are inadequate for analyzing such a phenomenon because they provide only an aggregated measure of interactions over time. To address this considerable limitation, we propose a dynamic Bayesian model which captures the time-varying nature of neuronal activity (such as the time-varying strength of the interactions between neurons). The proposed method yielded results that reveal new insight into the dynamic nature of population coding in the prefrontal cortex during decision making. In our analysis, we note that while some neurons in the prefrontal cortex do not synchronize their firing activity until the presence of a reward, a different set of neurons synchronize their activity shortly after stimulus onset. These differentially synchronizing sub-populations of neurons suggests a continuum of population representation of the reward-seeking task. Secondly, our analyses also suggest that the degree of synchronization differs between the rewarded and non-rewarded conditions. Moreover, the proposed model is scalable to handle data on many simultaneously-recorded neurons and is applicable to analyzing other types of multivariate time series data with latent structure. Supplementary materials (including computer codes) for our paper are available online.
DOI: 10.6084/m9.figshare.1627950.v2
title: A Dynamic Bayesian Model for Characterizing Cross-Neuronal Interactions During Decision-Making

description: The goal of this article is to develop a novel statistical model for studying cross-neuronal spike train interactions during decision-making. For an individual to successfully complete the task of decision-making, a number of temporally organized events must occur: stimuli must be detected, potential outcomes must be evaluated, behaviors must be executed or inhibited, and outcomes (such as reward or no-reward) must be experienced. Due to the complexity of this process, it is likely the case that decision-making is encoded by the temporally precise interactions between large populations of neurons. Most existing statistical models, however, are inadequate for analyzing such a phenomenon because they provide only an aggregated measure of interactions over time. To address this considerable limitation, we propose a dynamic Bayesian model that captures the time-varying nature of neuronal activity (such as the time-varying strength of the interactions between neurons). The proposed method yielded results that reveal new insight into the dynamic nature of population coding in the prefrontal cortex during decision-making. In our analysis, we note that while some neurons in the prefrontal cortex do not synchronize their firing activity until the presence of a reward, a different set of neurons synchronizes their activity shortly after stimulus onset. These differentially synchronizing subpopulations of neurons suggest a continuum of population representation of the reward-seeking task. Second, our analyses also suggest that the degree of synchronization differs between the rewarded and nonrewarded conditions. Moreover, the proposed model is scalable to handle data on many simultaneously recorded neurons and is applicable to analyzing other types of multivariate time series data with latent structure. Supplementary materials (including computer codes) for our article are available online.
DOI: 10.6084/m9.figshare.1627955
title: Petrography, geochemistry, and U–Pb detrital zircon dating of early Permian sedimentary rocks from the North Flank of the North China Craton: Implications for the late Palaeozoic tectonic evolution of the eastern Central Asian Orogenic Belt

description: Sedimentary rocks from the Hugete and Sanmianjing Formations are exposed on the North Flank of the North China Craton (NCC), southeast of the Central Asian Orogenic Belt (CAOB), and contain key evidence for understanding the late Palaeozoic tectonic setting of the northern margin of the NCC. The Hugete Formation is conformably overlain by the Sanmianjing Formation, and the detrital modes of sandstones from these two formations indicate that they were mainly derived from a continental block source. The geochemical characteristics of sandstones and pelites from the Hugete Formation suggest deposition in a shallow marine environment and derivation from a source composed of predominantly felsic magmatic rocks. Detrital zircon ages from the sandstones of the Hugete Formation include age modes at approximately 2500 and 1800 Ma, with smaller modes at 380–404 and 288.2 ± 8.2 Ma. Combined with previously reported age-diagnostic fossils, the youngest age of 288.2 ± 8.2 Ma constrains the depositional age of the Hugete and Sanmianjing Formations to the early Permian. Based on regional geology, these age data reveal that the following: (1) the sedimentary rocks of the Hugete and Sanmianjing Formations were sourced mainly from the NCC, located to the south; (2) the early Palaeozoic accretionary arc complex at the northern margin of the NCC experienced intense erosion before the early Permian and thus it did not appear as a concurrent hinterland uplift during the deposition of the Hugete and Sanmianjing Formations; and (3) no significant topography was generated between the study area and the NCC by the early Permian island arc and orogen. Age distribution patterns, as well as geochemical and petrographic data, indicate that the Hugete and Sanmianjing Formations were deposited in a newly opened intra-continental ocean basin formed in an extensional tectonic environment.
DOI: 10.6084/m9.figshare.1627955.v1
title: Petrography, geochemistry, and U–Pb detrital zircon dating of early Permian sedimentary rocks from the North Flank of the North China Craton: Implications for the late Palaeozoic tectonic evolution of the eastern Central Asian Orogenic Belt

description: Sedimentary rocks from the Hugete and Sanmianjing Formations are exposed on the North Flank of the North China Craton (NCC), southeast of the Central Asian Orogenic Belt (CAOB), and contain key evidence for understanding the late Palaeozoic tectonic setting of the northern margin of the NCC. The Hugete Formation is conformably overlain by the Sanmianjing Formation, and the detrital modes of sandstones from these two formations indicate that they were mainly derived from a continental block source. The geochemical characteristics of sandstones and pelites from the Hugete Formation suggest deposition in a shallow marine environment and derivation from a source composed of predominantly felsic magmatic rocks. Detrital zircon ages from the sandstones of the Hugete Formation include age modes at approximately 2500 and 1800 Ma, with smaller modes at 380–404 and 288.2 ± 8.2 Ma. Combined with previously reported age-diagnostic fossils, the youngest age of 288.2 ± 8.2 Ma constrains the depositional age of the Hugete and Sanmianjing Formations to the early Permian. Based on regional geology, these age data reveal that the following: (1) the sedimentary rocks of the Hugete and Sanmianjing Formations were sourced mainly from the NCC, located to the south; (2) the early Palaeozoic accretionary arc complex at the northern margin of the NCC experienced intense erosion before the early Permian and thus it did not appear as a concurrent hinterland uplift during the deposition of the Hugete and Sanmianjing Formations; and (3) no significant topography was generated between the study area and the NCC by the early Permian island arc and orogen. Age distribution patterns, as well as geochemical and petrographic data, indicate that the Hugete and Sanmianjing Formations were deposited in a newly opened intra-continental ocean basin formed in an extensional tectonic environment.
DOI: 10.6084/m9.figshare.1627959
title: The effects of different initiation time of exercise training on left ventricular remodeling and cardiopulmonary rehabilitation in patients with left ventricular dysfunction after myocardial infarction

description: <i>Purpose</i>: The purpose of this study was to determine whether different initiation of exercise training (ET) produces different effect sizes for left ventricular (LV) remodeling and cardiopulmonary rehabilitation in patients with LV dysfunction after myocardial infarction (MI). <i>Method</i>: Trials evaluating ET outcomes identified by searches in OVID MEDLINE, EMBASE, PubMed and WEB OF SCIENCE were used. Meta-analysis was conducted with the use of the software STATA 11.0. The results were expressed as the standardized mean difference (SMD), with corresponding 95% CI and <i>p</i> value. <i>Results</i>: The largest changes in LV remodeling and cardiopulmonary capacity rehabilitation were obtained when programs began the acute phase after MI. With the healing of MI, the beneficial effects of ET on LV ejection fraction (LVEF), LV end-systolic diameter (LVDs) and peak VO<sub>2</sub> were gradually weakened even worse. The incidence of major adverse cardiac events was not significantly increased in acute phase post-MI. Sensitivity analyses show that ET still had significant effect in reducing LVDs and increasing peak VO<sub>2</sub>, while ET no longer had statistical effect in increasing LVEF but showed favorable trends when the same research institution's works were excluded. <i>Conclusions</i>: ET has favorable effects on LV remodeling and cardiopulmonary rehabilitation in LV dysfunction post-MI patients. The greatest benefits are obtained when ET starts at the acute phase following MI.Implications for RehabilitationEarly exercise training is safe and feasible in acute and healing phase after myocardial infarction.Early exercise training could attenuate LV remodeling and improve cardiopulmonary capacity in patients with myocardial infarction after hospital discharge (around one week post-MI).Exercise training has favorable effects on LV remodeling and cardiopulmonary capacity rehabilitation. Exercise training should be treated to have the same roles with drugs in secondary prevention of myocardial infarction.
DOI: 10.6084/m9.figshare.1627959.v1
title: The effects of different initiation time of exercise training on left ventricular remodeling and cardiopulmonary rehabilitation in patients with left ventricular dysfunction after myocardial infarction

description: <i>Purpose</i>: The purpose of this study was to determine whether different initiation of exercise training (ET) produces different effect sizes for left ventricular (LV) remodeling and cardiopulmonary rehabilitation in patients with LV dysfunction after myocardial infarction (MI). <i>Method</i>: Trials evaluating ET outcomes identified by searches in OVID MEDLINE, EMBASE, PubMed and WEB OF SCIENCE were used. Meta-analysis was conducted with the use of the software STATA 11.0. The results were expressed as the standardized mean difference (SMD), with corresponding 95% CI and <i>p</i> value. <i>Results</i>: The largest changes in LV remodeling and cardiopulmonary capacity rehabilitation were obtained when programs began the acute phase after MI. With the healing of MI, the beneficial effects of ET on LV ejection fraction (LVEF), LV end-systolic diameter (LVDs) and peak VO<sub>2</sub> were gradually weakened even worse. The incidence of major adverse cardiac events was not significantly increased in acute phase post-MI. Sensitivity analyses show that ET still had significant effect in reducing LVDs and increasing peak VO<sub>2</sub>, while ET no longer had statistical effect in increasing LVEF but showed favorable trends when the same research institution's works were excluded. <i>Conclusions</i>: ET has favorable effects on LV remodeling and cardiopulmonary rehabilitation in LV dysfunction post-MI patients. The greatest benefits are obtained when ET starts at the acute phase following MI.Implications for RehabilitationEarly exercise training is safe and feasible in acute and healing phase after myocardial infarction.Early exercise training could attenuate LV remodeling and improve cardiopulmonary capacity in patients with myocardial infarction after hospital discharge (around one week post-MI).Exercise training has favorable effects on LV remodeling and cardiopulmonary capacity rehabilitation. Exercise training should be treated to have the same roles with drugs in secondary prevention of myocardial infarction.
DOI: 10.6084/m9.figshare.1629331
title: A comparative study of expected improvement-assisted global optimization with different surrogates

description: Efficient global optimization (EGO) uses the surrogate uncertainty estimator called expected improvement (EI) to guide the selection of the next sampling candidates. Theoretically, any modelling methods can be integrated with the EI criterion. To improve the convergence ratio, a multi-surrogate efficient global optimization (MSEGO) was suggested. In practice, the EI-based optimization methods with different surrogates show widely divergent characteristics. Therefore, it is important to choose the most suitable algorithm for a certain problem. For this purpose, four single-surrogate efficient global optimizations (SSEGOs) and an MSEGO involving four surrogates are investigated. According to numerical tests, both the SSEGOs and the MSEGO are feasible for weak nonlinear problems. However, they are not robust for strong nonlinear problems, especially for multimodal and high-dimensional problems. Moreover, to investigate the feasibility of EGO in practice, a material identification benchmark is designed to demonstrate the performance of EGO methods. According to the tests in this study, the kriging EGO is generally the most robust method.
DOI: 10.6084/m9.figshare.1629331.v1
title: A comparative study of expected improvement-assisted global optimization with different surrogates

description: Efficient global optimization (EGO) uses the surrogate uncertainty estimator called expected improvement (EI) to guide the selection of the next sampling candidates. Theoretically, any modelling methods can be integrated with the EI criterion. To improve the convergence ratio, a multi-surrogate efficient global optimization (MSEGO) was suggested. In practice, the EI-based optimization methods with different surrogates show widely divergent characteristics. Therefore, it is important to choose the most suitable algorithm for a certain problem. For this purpose, four single-surrogate efficient global optimizations (SSEGOs) and an MSEGO involving four surrogates are investigated. According to numerical tests, both the SSEGOs and the MSEGO are feasible for weak nonlinear problems. However, they are not robust for strong nonlinear problems, especially for multimodal and high-dimensional problems. Moreover, to investigate the feasibility of EGO in practice, a material identification benchmark is designed to demonstrate the performance of EGO methods. According to the tests in this study, the kriging EGO is generally the most robust method.
DOI: 10.6084/m9.figshare.1629359
title: A new Early Cretaceous enantiornithine (Aves, Ornithothoraces) from northwestern China with elaborate tail ornamentation

description: We provide a detailed description of a well-preserved enantiornithine specimen (GSGM-05-CM-004) from the Lower Cretaceous (Aptian) Xiagou Formation of northwestern Gansu Province, China, for which we erect the new taxon <i>Feitianius paradisi</i>, gen. et sp. nov. This specimen has a distinctive pelvic morphology and can be further distinguished from all other Mesozoic birds by a unique caudal plumage formed by multiple rectricial morphotypes. This newly documented tail morphology reveals a previously unrecognized level of complexity in the plumage of basal birds. This complex tail-feather morphology has a parallel in extant sexually dimorphic birds in which the males have the most altered tails; thus, we identify this specimen as male. Ornamental tail morphologies, such as the novel tail plumage described here, dominate Enantiornithes. This reinforces hypotheses that sexual selection was a major driving force in the evolution of basal bird plumage. http://zoobank.org/urn:lsid:zoobank.org:pub:8BEF4422-58C5-487B-B76A-51C5855CF87B SUPPLEMENTAL DATA—Supplemental materials are available for this article for free at www.tandfonline.com/UJVP Citation for this article: O’Connor, J. K., D.-Q. Li, M. C. Lamanna, M. Wang, J. D. Harris, J. Atterholt, and H.-L. You. 2015. A new Early Cretaceous enantiornithine (Aves, Ornithothoraces) from northwestern China with elaborate tail ornamentation. Journal of Vertebrate Paleontology. DOI: 10.1080/02724634.2015.1054035.
DOI: 10.6084/m9.figshare.1629359.v1
title: A new Early Cretaceous enantiornithine (Aves, Ornithothoraces) from northwestern China with elaborate tail ornamentation

description: We provide a detailed description of a well-preserved enantiornithine specimen (GSGM-05-CM-004) from the Lower Cretaceous (Aptian) Xiagou Formation of northwestern Gansu Province, China, for which we erect the new taxon <i>Feitianius paradisi</i>, gen. et sp. nov. This specimen has a distinctive pelvic morphology and can be further distinguished from all other Mesozoic birds by a unique caudal plumage formed by multiple rectricial morphotypes. This newly documented tail morphology reveals a previously unrecognized level of complexity in the plumage of basal birds. This complex tail-feather morphology has a parallel in extant sexually dimorphic birds in which the males have the most altered tails; thus, we identify this specimen as male. Ornamental tail morphologies, such as the novel tail plumage described here, dominate Enantiornithes. This reinforces hypotheses that sexual selection was a major driving force in the evolution of basal bird plumage. http://zoobank.org/urn:lsid:zoobank.org:pub:8BEF4422-58C5-487B-B76A-51C5855CF87B SUPPLEMENTAL DATA—Supplemental materials are available for this article for free at www.tandfonline.com/UJVP Citation for this article: O’Connor, J. K., D.-Q. Li, M. C. Lamanna, M. Wang, J. D. Harris, J. Atterholt, and H.-L. You. 2015. A new Early Cretaceous enantiornithine (Aves, Ornithothoraces) from northwestern China with elaborate tail ornamentation. Journal of Vertebrate Paleontology. DOI: 10.1080/02724634.2015.1054035.
DOI: 10.6084/m9.figshare.1629360
title: Identification and characterization of microRNAs in Eucheuma denticulatum by high-throughput sequencing and bioinformatics analysis

description: <i>Eucheuma denticulatum</i>, an economically and industrially important red alga, is a valuable marine resource. Although microRNAs (miRNAs) play an essential role in gene post-transcriptional regulation, no research has been conducted to identify and characterize miRNAs in <i>E. denticulatum</i>. In this study, we identified 134 miRNAs (133 conserved miRNAs and one novel miRNA) from 2,997,135 small-RNA reads by high-throughput sequencing combined with bioinformatics analysis. BLAST searching against miRBase uncovered 126 potential miRNA families. A conservation and diversity analysis of predicted miRNA families in different plant species was performed by comparative alignment and homology searching. A total of 4 and 13 randomly selected miRNAs were respectively validated by northern blotting and stem-loop reverse transcription PCR, thereby demonstrating the reliability of the miRNA sequencing data. Altogether, 871 potential target genes were predicted using psRobot and TargetFinder. Target genes classification and enrichment were conducted based on Gene Ontology analysis. The functions of target gene products and associated metabolic pathways were predicted by Kyoto Encyclopedia of Genes and Genomes pathway analysis. A Cytoscape network was constructed to explore the interrelationships of miRNAs, miRNA-target genes and target genes. A large number of miRNAs with diverse target genes will play important roles for further understanding some essential biological processes in <i>E. denticulatum</i>. The uncovered information can serve as an important reference for the protection and utilization of this unique red alga in the future.