cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.20651049.v1
title: Supplementary Material for: Patient-Reported Outcomes and Predictive Factors following Focused Ultrasound Thalamotomy for Essential Tremor

description: <b><i>Introduction:</i></b> The objectives of this study were to determine long-term patient-reported outcomes with magnetic resonance-guided focused ultrasound (MRgFUS) thalamotomy for medication-refractory essential tremor (ET) and to identify risk factors for a poor clinical outcome. <b><i>Methods:</i></b> We administered a telephone or mail-in survey to patients who consecutively underwent unilateral MRgFUS thalamotomy for ET at our institution over an 8-year period. Patients were asked to self-report measures of hand tremor improvement, degree of overall postprocedure improvement, activities of daily life, side effects, and willingness to undergo the procedure again. Specific patient characteristics, ultrasound treatment parameters, and postoperative radiological findings from magnetic resonance imaging performed 1 day after the procedure were analyzed, and multivariable linear regression was used to determine if these factors could serve as predictors of clinical outcome. <b><i>Results:</i></b> A total of 85 patients were included in this study with a mean follow-up time of 3.0 years (range 2 months to 1 8.4 years). The mean patient-reported improvement in hand tremor at last follow-up was 66%, and 73% of patients reported meaningful change in their overall condition after the procedure. The percentages of patients reporting normal or only minimal limitations with feeding, drinking, and writing ability at last follow-up were 60%, 71%, and 48%, respectively. In the position of their former selves, 89% of patients would again choose to undergo the procedure. Larger lesions were correlated with a higher risk of adverse events. <b><i>Discussion/Conclusion:</i></b> While subjective hand tremor improvement declines with time, willingness to undergo the procedure again following MRgFUS thalamotomy for ET remains very high even several years after the procedure.
DOI: 10.6084/m9.figshare.20282097
title: Supplementary Material for: Are There Racial Differences in Inpatient Outcomes and Treatment Utilization Following Hospitalization for Myasthenia Gravis Exacerbation?

description: Introduction Racial differences in healthcare utilization and outcomes in the United remain an important issue. Little is known about racial differences in inpatient outcomes following hospitalizations for myasthenia gravis (MG). In this study, we used a claim-based database to assess racial differences in outcomes in hospitalized myasthenics. Methods The 2006 to 2014 National Inpatient Sample (NIS) database was queried using the International Classification of Diseases 9th Edition (ICD-9) diagnosis code (358.01) to identify adult patients (age &gt;17 years) undergoing hospitalization for MG. Race was categorized into – White, Black/African American, Asian or Pacific Islander, Hispanic, Native American, and other. Complications assessed included urinary tract infections, acute renal failure, cardiac complications, systemic infection, deep venous thrombosis, and pulmonary embolism. Multivariate logistic regression analyses were used to assess whether race was associated with a difference in outcomes, after controlling for baseline demographics, hospital characteristics and treatment factors. For regression purposes, White race was used as the reference. Results A total of 56,189 patient admissions, using a weighted sample, underwent hospitalization for MG between 2006 to 2014. Black/ African American patients had significantly higher odds of experiencing systemic infections (OR 1.35 [95% CI 1.16-1.58]; p&lt;0.001), deep venous thrombosis (OR 2.11 [95% CI 1.36-3.27]; p=0.001) and renal failure (OR 1.19 [95% CI 1.05-1.35]; p=0.005). Black/African American patients were more likely to be intubated (OR 1.09 [95% CI 1.01-1.19]; p=0.028) and receive non-invasive mechanical ventilation (OR 1.62 [95% CI 1.46-1.79]; p&lt;0.001), however, were less likely to receive IVIG (OR 0.77 [95% CI 0.73-0.82]; p&lt;0.001) and plasmapheresis (OR 0.77 [95% CI 0.72-0.82]; p&lt;0.001). Black/African American and Hispanic patients had lower mortality (OR 0.74 [95% CI 0.59-0.94; p=0.012]. Conclusions Significant racial differences exist in both treatment utilization and inpatient outcomes for patients hospitalized for MG.
DOI: 10.6084/m9.figshare.20291619.v1
title: Supplementary Material for: Heterogeneity in estimates of incidence and prevalence of narcolepsy: a systematic review and meta-regression analysis

description: Introduction: Narcolepsy is a chronic neurological disorder. The diagnostic criteria of narcolepsy evolve from clinical symptoms to molecular biomarkers, along with the understanding of its clinical nature and pathogenesis. Estimates of incidence and prevalence of narcolepsy vary between studies, while the contribution of changing diagnostic criteria to the variation remains unclear. We aimed to explore sources of heterogeneity in estimates of incidence and prevalence, with a particular focus on diagnostic criteria. Methods: We searched 5 databases for observational studies on the incidence or prevalence of narcolepsy published before October 14, 2021. Subgroup analyses and meta-regression were used to assess the impact of diagnostic criteria on incidence/prevalence of narcolepsy after adjusting for age group, region, study period, vaccination status, index date, and type of narcolepsy. Results: 35 studies were selected from 2,833 articles. The estimates of incidence and prevalence were wide-ranging with high heterogeneity (incidence I2 = 99.8%; prevalence I2 = 99.7%), from 0.06–6.56 per 100,000 person-years for incidence and 1.05–79.40 per 100,000 population for prevalence, respectively. Totally 10 diagnostic criteria were used, including the 1st revised edition of International Classification of Diseases (ICSD-1), ICSD-2, ICSD-3, the 8th revision of International Classification of Diseases (ICD-8), ICD-9, ICD-10, Brighton collaboration case definition (Brighton), Mayo classification, the Ullanlinna Narcolepsy Scale, and clinical symptoms with the multiple sleep latency test. ICD tended to provide higher estimates of incidence/prevalence than Brighton (incidence odds ratio [OR] 1.38, [95% CI 1.02, 1.86]; prevalence OR 1.50, [95% CI 1.04, 2.39]). No significant difference was found in estimates of two rates between ICSD and Brighton. Incidence was higher for children than adults (OR 1.61, [95% CI 1.25, 2.07]), and for individuals vaccinated with Pandemrix than those unvaccinated (OR 6.49, [95% CI 3.86, 10.91]). Conclusions: Estimates of incidence/prevalence of narcolepsy could not be pooled reliably with substantial heterogeneity. Incidence/prevalence studies using ICSD and Brighton provided lower estimates than studies using ICD and other criteria. Diagnostic criteria should be standardized when comparing or pooling the incidence/prevalence to understand the epidemiology of narcolepsy. Future studies are needed to focus on the at-risk population for the etiology investigation of narcolepsy.
DOI: 10.6084/m9.figshare.20652083
title: Additional file 2 of Redefining germline predisposition in children with molecularly characterized ependymoma: a population-based 20-year cohort

description: Additional file 2: Table S1. Overview of the 390 genes associated with cancer included in the panel analysis. Table S2. Genes reported with potential germline/somatic role in ependymoma. Table S3. Constrained genes manual curation results. Table S4. Cohort overview: clinical, histopathological and molecular data. Table S5. Overview of pathogenic variants in known cancer associated genes and pLoF variants in evolutionarily constrained genes by molecular tumor type. Table S6. Five heterozygous loss-of-function variants in recessive genes considered unrelated to ependymoma.
DOI: 10.6084/m9.figshare.20652083.v1
title: Additional file 2 of Redefining germline predisposition in children with molecularly characterized ependymoma: a population-based 20-year cohort

description: Additional file 2: Table S1. Overview of the 390 genes associated with cancer included in the panel analysis. Table S2. Genes reported with potential germline/somatic role in ependymoma. Table S3. Constrained genes manual curation results. Table S4. Cohort overview: clinical, histopathological and molecular data. Table S5. Overview of pathogenic variants in known cancer associated genes and pLoF variants in evolutionarily constrained genes by molecular tumor type. Table S6. Five heterozygous loss-of-function variants in recessive genes considered unrelated to ependymoma.
DOI: 10.6084/m9.figshare.20155590.v1
title: Additional file 2 of DNA methylation changes in response to neoadjuvant chemotherapy are associated with breast cancer survival

description: Additional file 2. A table showing the four-CpG DNA methylation risk score created by the leave-one out LASSO model and their coefficients.
DOI: 10.6084/m9.figshare.20155590
title: Additional file 2 of DNA methylation changes in response to neoadjuvant chemotherapy are associated with breast cancer survival

description: Additional file 2. A table showing the four-CpG DNA methylation risk score created by the leave-one out LASSO model and their coefficients.
DOI: 10.6084/m9.figshare.20155593
title: Additional file 3 of DNA methylation changes in response to neoadjuvant chemotherapy are associated with breast cancer survival

description: Additional file 3. A list of the significant CpG sites before vs after treatment in survivors, along with the p value and Illumina annotation for each site.
DOI: 10.6084/m9.figshare.20155593.v1
title: Additional file 3 of DNA methylation changes in response to neoadjuvant chemotherapy are associated with breast cancer survival

description: Additional file 3. A list of the significant CpG sites before vs after treatment in survivors, along with the p value and Illumina annotation for each site.
DOI: 10.6084/m9.figshare.20652152
title: Additional file 1 of Assessing whether genetic scores explain extra variation in birthweight, when added to clinical and anthropometric measures

description: Additional file 1. SNPs used to create genetic scores. This file contains a list of all the SNPs used to create the genetic scores.
DOI: 10.6084/m9.figshare.20652152.v1
title: Additional file 1 of Assessing whether genetic scores explain extra variation in birthweight, when added to clinical and anthropometric measures

description: Additional file 1. SNPs used to create genetic scores. This file contains a list of all the SNPs used to create the genetic scores.
DOI: 10.6084/m9.figshare.20652163
title: Additional file 1 of FPocketWeb: protein pocket hunting in a web browser

description: Additional file 1. The FPocketWeb source code, version 1.0.1. See http://durrantlab.com/fpocketweb-download for the latest version.
DOI: 10.6084/m9.figshare.20652163.v1
title: Additional file 1 of FPocketWeb: protein pocket hunting in a web browser

description: Additional file 1. The FPocketWeb source code, version 1.0.1. See http://durrantlab.com/fpocketweb-download for the latest version.
DOI: 10.6084/m9.figshare.20652169
title: Additional file 2 of Evolution of transcriptional regulation of histidine metabolism in Gram-positive bacteria

description: Additional file 2. Distribution of histidine biosynthesis genes, transporters and regulons in Firmicutes genomes.
DOI: 10.6084/m9.figshare.20652169.v1
title: Additional file 2 of Evolution of transcriptional regulation of histidine metabolism in Gram-positive bacteria

description: Additional file 2. Distribution of histidine biosynthesis genes, transporters and regulons in Firmicutes genomes.
DOI: 10.6084/m9.figshare.20652172
title: Additional file 3 of Evolution of transcriptional regulation of histidine metabolism in Gram-positive bacteria

description: Additional file 3. (A) Predicted HisR-binding sites and reconstructed regulons in other lineages; (B) Distribution of histidine biosynthesis genes and transporters in other lineages.
DOI: 10.6084/m9.figshare.20652172.v1
title: Additional file 3 of Evolution of transcriptional regulation of histidine metabolism in Gram-positive bacteria

description: Additional file 3. (A) Predicted HisR-binding sites and reconstructed regulons in other lineages; (B) Distribution of histidine biosynthesis genes and transporters in other lineages.
DOI: 10.6084/m9.figshare.20652175.v1
title: Additional file 4 of Evolution of transcriptional regulation of histidine metabolism in Gram-positive bacteria

description: Additional file 4. (A) Predicted HisR-binding sites (A) and Histidine-specific T-boxes (B) and the reconstructed regulons in Firmicutes genomes.
DOI: 10.6084/m9.figshare.20652175
title: Additional file 4 of Evolution of transcriptional regulation of histidine metabolism in Gram-positive bacteria

description: Additional file 4. (A) Predicted HisR-binding sites (A) and Histidine-specific T-boxes (B) and the reconstructed regulons in Firmicutes genomes.
DOI: 10.6084/m9.figshare.20652187
title: Additional file 8 of Evolution of transcriptional regulation of histidine metabolism in Gram-positive bacteria

description: Additional file 8. Outputs of cmsearch (Infernal) with alignments of candidate histidine-specific T-boxes in Firmicutes.
DOI: 10.6084/m9.figshare.20652187.v1
title: Additional file 8 of Evolution of transcriptional regulation of histidine metabolism in Gram-positive bacteria

description: Additional file 8. Outputs of cmsearch (Infernal) with alignments of candidate histidine-specific T-boxes in Firmicutes.
DOI: 10.6084/m9.figshare.20652256
title: Additional file 1 of A novel theatre-based behaviour change approach for influencing community uptake of schistosomiasis control measures

description: Additional file 1: Text S1. Qualitative interviews and focus group discussions topic guide and questions. Text S2. Acting for Health methodology. Table S1. Intervention workshop cohort and drama and film audience survey responses. Table S2. Emergent themes and narrative quotations from formative qualitative findings. Table S3. Quantitative questionnaire survey results for baseline and post intervention for Tanzania. Table S4. Quantitative questionnaire survey results for baseline and post intervention for Ethiopia.
DOI: 10.6084/m9.figshare.20652259
title: Additional file 2 of A novel theatre-based behaviour change approach for influencing community uptake of schistosomiasis control measures

description: Additional file 2: Figure S1. Some selected images from intervention workshops. Figure S2. Flyer with life cycle, transmission and control in Tanzania
DOI: 10.6084/m9.figshare.20652259.v1
title: Additional file 2 of A novel theatre-based behaviour change approach for influencing community uptake of schistosomiasis control measures

description: Additional file 2: Figure S1. Some selected images from intervention workshops. Figure S2. Flyer with life cycle, transmission and control in Tanzania
DOI: 10.6084/m9.figshare.20652281
title: Additional file 3 of Capturing the antibiotic resistome of preterm infants reveals new benefits of probiotic supplementation

description: Additional file 3. Results of enrichment for ARGs – Details on library preparation, enrichment, sequencing and analysis results for each sample.
DOI: 10.6084/m9.figshare.20652281.v1
title: Additional file 3 of Capturing the antibiotic resistome of preterm infants reveals new benefits of probiotic supplementation

description: Additional file 3. Results of enrichment for ARGs – Details on library preparation, enrichment, sequencing and analysis results for each sample.
DOI: 10.6084/m9.figshare.20652284
title: Additional file 4 of Capturing the antibiotic resistome of preterm infants reveals new benefits of probiotic supplementation

description: Additional file 4. Predicted bacterial host of ARGs – For a subset of ARGs, the bacterial host was predicted through various analysis approaches.
DOI: 10.6084/m9.figshare.20652284.v1
title: Additional file 4 of Capturing the antibiotic resistome of preterm infants reveals new benefits of probiotic supplementation

description: Additional file 4. Predicted bacterial host of ARGs – For a subset of ARGs, the bacterial host was predicted through various analysis approaches.
DOI: 10.6084/m9.figshare.20652287
title: Additional file 5 of Capturing the antibiotic resistome of preterm infants reveals new benefits of probiotic supplementation

description: Additional file 5. Negative control results – Results of negative controls included throughout the workflow and sequencing results for one sample.
DOI: 10.6084/m9.figshare.20652287.v1
title: Additional file 5 of Capturing the antibiotic resistome of preterm infants reveals new benefits of probiotic supplementation

description: Additional file 5. Negative control results – Results of negative controls included throughout the workflow and sequencing results for one sample.
DOI: 10.25934/pr00007801
title: Elucidation of the predictive factors for active and placebo drug response on social functioning and quality of life (QOL) in psychiatric illnesses including developmental disorders

description: Attention deficit hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by inattention, excessive activity and impulsivity.  ADHD is estimated to affect about 6–7% of child and adolescent and several but certain percentages of adult.  ADHD significantly affects the quality of life (QOL) of patients and their families.  This is an individual participant data (IPD) level meta-analysis for estimating factors leading to improve the quality of life (QOL) in the Japanese patient with ADHD, in order to reduce the burden on them and their families.  This research collects placebo-controlled clinical studies evaluated QOL, makes integrated data set and identifies factors leading to improve the QOL in the patient with ADHD by statistical analyses.
DOI: 10.21227/sa2g-8r42
title: Chinese character gesture data

description: A Chinese character gesture dataset for 8 Chinese characters ( “国”，“图”，“木”，“工”，“口”，“中”，“国”，“人” ) .Datasets were collected in three different environments.
DOI: 10.5281/zenodo.6807403
title: MIMIC PERform Datasets

description: The MIMIC PERform datasets are a series of datasets extracted from the MIMIC III Waveform Database. Each dataset contains recordings of physiological signals from critically-ill patients during routine clinical care. Specifically, the datasets contain the following signals: electrocardiogram (ECG) photoplethysmogram (PPG) impedance pneumography (imp), also known as respiratory (resp) Further details of the datasets are provided in the documentation accompanying the ppg-beats project, which is available at: https://ppg-beats.readthedocs.io/en/latest/ . In particular, documentation is provided on the following datasets: <strong>MIMIC PERform AF Dataset: </strong>Recordings from 35 critically-ill adults during routine clinical care, categorised as either AF (atrial fibrillation, 19 subjects) or non-AF (16 subjects). Matlab format (all data, adults, neonates) WFDB format (all data, adults, neonates) CSV format (all data, adults, neonates) <strong>MIMIC PERform Training Dataset: </strong>Recordings from 200 patients during routine clinical care, who are categorised as either adults (100 subjects) or neonates (100 subjects). Matlab format (all data, adults, neonates) WFDB format (all data, adults, neonates) CSV format (all data, adults, neonates) <strong>MIMIC PERform Testing Dataset: </strong>Recordings from 200 patients during routine clinical care, who are categorised as either adults (100 subjects) or neonates (100 subjects). Matlab format (AF subjects, non-AF subjects) WFDB format (AF subjects, non-AF subjects) CSV format (AF subjects, non-AF subjects) Each dataset is accompanied by a licence which acknowledges the source(s) of the data - please see the individual licenses for these acknowledgements.
description: This work was supported by British Heart Foundation (BHF) grants [FS/20/20/34626] and [PG/15/104/31913], and an EPSRC Impact Acceleration Award.
DOI: 10.5281/zenodo.7024516
title: Sphingosine 1-Phosphate Mediates Adiponectin Receptor Signaling Essential For Lipid Homeostasis and Embryogenesis

description: Lipidomics and Proteomics data sets referred in preprint: 10.1101/2021.08.12.456080
DOI: 10.5281/zenodo.7024515
title: Sphingosine 1-Phosphate Mediates Adiponectin Receptor Signaling Essential For Lipid Homeostasis and Embryogenesis

description: Lipidomics and Proteomics data sets referred in preprint: 10.1101/2021.08.12.456080
DOI: 10.25574/13788
title: Chandra X-ray Observatory ObsId 13788

description: Investigating the Nature of the Unusual 59 ms Pulsar 'Calvera'
DOI: 10.34740/kaggle/dsv/4123397
title: AutoXGB
DOI: 10.6084/m9.figshare.20449131
title: Data of Trace gas fluxes from tidal salt marsh soils (CO2, CH4, N2O, CS2 and DMS)

description: Data of Trace gas fluxes from tidal salt marsh soils (CO2, CH4, N2O, CS2 and DMS)
DOI: 10.6084/m9.figshare.20115782
title: Additional file 1 of Target capture sequencing reveals a monoclonal outbreak of respiratory syncytial virus B infections among adult hematologic patients

description: Additional file 1. GenBank accession numbers of RSV-A genomes applied in probe design
DOI: 10.6084/m9.figshare.20115785
title: Additional file 2 of Target capture sequencing reveals a monoclonal outbreak of respiratory syncytial virus B infections among adult hematologic patients

description: Additional file 2. GenBank accession numbers of RSV-B genomes applied in probe design
DOI: 10.6084/m9.figshare.20115785.v1
title: Additional file 2 of Target capture sequencing reveals a monoclonal outbreak of respiratory syncytial virus B infections among adult hematologic patients

description: Additional file 2. GenBank accession numbers of RSV-B genomes applied in probe design
DOI: 10.6084/m9.figshare.20115782.v1
title: Additional file 1 of Target capture sequencing reveals a monoclonal outbreak of respiratory syncytial virus B infections among adult hematologic patients

description: Additional file 1. GenBank accession numbers of RSV-A genomes applied in probe design
DOI: 10.6084/m9.figshare.20115791
title: Additional file 4 of Target capture sequencing reveals a monoclonal outbreak of respiratory syncytial virus B infections among adult hematologic patients

description: Additional file 4. Fasta files of all RSV capture probes
DOI: 10.6084/m9.figshare.20115791.v1
title: Additional file 4 of Target capture sequencing reveals a monoclonal outbreak of respiratory syncytial virus B infections among adult hematologic patients

description: Additional file 4. Fasta files of all RSV capture probes
DOI: 10.6084/m9.figshare.20115794.v1
title: Additional file 5 of Target capture sequencing reveals a monoclonal outbreak of respiratory syncytial virus B infections among adult hematologic patients

description: Additional file 5. Summary of short read sequencing results
DOI: 10.6084/m9.figshare.20115800
title: Additional file 7 of Target capture sequencing reveals a monoclonal outbreak of respiratory syncytial virus B infections among adult hematologic patients

description: Additional file 7. Overview of SNPs of all RSV sequences obtained
DOI: 10.6084/m9.figshare.20115794
title: Additional file 5 of Target capture sequencing reveals a monoclonal outbreak of respiratory syncytial virus B infections among adult hematologic patients

description: Additional file 5. Summary of short read sequencing results
DOI: 10.6084/m9.figshare.20115800.v1
title: Additional file 7 of Target capture sequencing reveals a monoclonal outbreak of respiratory syncytial virus B infections among adult hematologic patients

description: Additional file 7. Overview of SNPs of all RSV sequences obtained