cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.9943946.v1
title: Open-Wedge HTO with Absorbable β-TCP/PLGA Spacer Implantation and Proximal Fibular Osteotomy for Medial Compartmental Knee Osteoarthritis: New Technique Presentation

description: The purpose of this study was to present a new absorbable spacer for medial compartmental knee osteoarthritis (OA). The functional and radiographic results of patients treated with the novel surgical technique were also evaluated to investigate its clinical feasibility. Patients with medial compartmental knee OA who underwent open-wedge high tibial osteotomy (HTO) with absorbable β-TCP/PLGA [30% beta-tricalcium phosphate and 70% poly (lactic-co-glycolic acid)] spacer implantation and proximal fibular osteotomy from January 2016 to February 2017 were retrospectively analyzed. The operation time, blood loss, and relevant complications were reviewed. The femorotibial angle (FTA), varus angle (VA), joint line convergence angle (JLCA), American Knee Society Score (KSS), and visual analog scale (VAS) score were recorded preoperatively and at the final follow-up, respectively. At the final follow-up, the mean FTA and JLCA were 179.85° ± 4.34° and 2.44° ± 1.26°, respectively, which were smaller than the preoperative values (182.94° ± 3.86° and 4.12° ± 1.65°, respectively; both <i>p</i> &lt; 0.001). The final VA and VAS score were lower than those measured preoperatively (both <i>p</i> &lt; 0.001). The clinical and functional KSSs at the final follow-up were higher than the preoperative scores (<i>p</i> &lt; 0.001). This novel absorbable spacer could provide adequate stability for the tibial osteotomy gap, at a lower cost than a traditional plate. With the use of this spacer as an osteoinductive and biodegradable device, secondary surgery for fixation removal could be avoided. The novel surgical technique could improve both the radiographic appearance and the function of the knee in patients with knee OA.
DOI: 10.6084/m9.figshare.9943985
title: Rv0807, a putative phospholipase A2 of <i>Mycobacterium tuberculosis</i>; Elucidation through sequence analysis, homology modeling, molecular docking and molecular dynamics studies of potential substrates and inhibitors

description: <i>Mycobacterium tuberculosis</i> (Mtb) has the ability to scrounge off the host macrophages and create a cordial environment for its survival. Identification of mechanisms favoring this purpose leads to novel treatment strategies for tuberculosis. In this study through in silico approaches, we intend to identify the putative role for Rv0807 from Mtb and its essentiality for mycobacterium survival within the macrophages. Through sequence analysis, we hypothesize that Rv0807 could be a Phospholipase A2 of Mtb. Moreover, through in silico mutation studies we have predicted certain residues to be a part of the catalytic process of the Rv0807 homodimer. Rv0807 could be a potential drug target as it binds phosphatidylinositol-3-phosphate (PI3P) and could be involved in processing the host cell PI3Ps, thereby blocking the phagosomal maturation. A pharmacophore hypothesis was generated for the Rv0807 homodimer based on the ligand binding site and a set of Pretomanid related compounds were screened against the Rv0807 homodimer. The top five compounds which had better docking scores and good ADME properties were selected as best inhibitory compounds and analyzed further. Molecular dynamics (MD) studies of Rv0807 homodimer with PI3P and with the top scored compound in docking studies, demonstrated a lot of conformational changes in the protein structure as it gets occluded through the course of simulation. The movement of a loop atop the ligand binding site, suggests of a lid-like region as seen in many other phospholipases. MD simulation of the mutant structures was also performed and its effect on the protein conformational changes was discussed. Communicated by Ramaswamy H. Sarma
DOI: 10.6084/m9.figshare.9943985.v2
title: Rv0807, a putative phospholipase A2 of <i>Mycobacterium tuberculosis</i>; Elucidation through sequence analysis, homology modeling, molecular docking and molecular dynamics studies of potential substrates and inhibitors

description: <i>Mycobacterium tuberculosis</i> (Mtb) has the ability to scrounge off the host macrophages and create a cordial environment for its survival. Identification of mechanisms favoring this purpose leads to novel treatment strategies for tuberculosis. In this study through in silico approaches, we intend to identify the putative role for Rv0807 from Mtb and its essentiality for mycobacterium survival within the macrophages. Through sequence analysis, we hypothesize that Rv0807 could be a Phospholipase A2 of Mtb. Moreover, through in silico mutation studies we have predicted certain residues to be a part of the catalytic process of the Rv0807 homodimer. Rv0807 could be a potential drug target as it binds phosphatidylinositol-3-phosphate (PI3P) and could be involved in processing the host cell PI3Ps, thereby blocking the phagosomal maturation. A pharmacophore hypothesis was generated for the Rv0807 homodimer based on the ligand binding site and a set of Pretomanid related compounds were screened against the Rv0807 homodimer. The top five compounds which had better docking scores and good ADME properties were selected as best inhibitory compounds and analyzed further. Molecular dynamics (MD) studies of Rv0807 homodimer with PI3P and with the top scored compound in docking studies, demonstrated a lot of conformational changes in the protein structure as it gets occluded through the course of simulation. The movement of a loop atop the ligand binding site, suggests of a lid-like region as seen in many other phospholipases. MD simulation of the mutant structures was also performed and its effect on the protein conformational changes was discussed. Communicated by Ramaswamy H. Sarma
DOI: 10.6084/m9.figshare.9943988
title: How to Pick Out the “Unreal” Gleason 3 + 3 Patients: A Nomogram for More Precise Active Surveillance Protocol in Low-Risk Prostate Cancer in a Chinese Population

description: To develop a nomogram for selecting the “unreal” Gleason score (GS) 3 + 3 patients in biopsy GS 3 + 3 prostate cancer (PCa) patients. Patients who were newly diagnosed with PCa by biopsy and underwent radical prostatectomy in the First Affiliated Hospital of Nanjing Medical University from January 2009 to October 2018 were enrolled. Comparisons were made between GS 3 + 3 and higher grade PCa patients. Logistic regression analysis was performed to determine the risk factors for the “unreal” GS 3 + 3 PCa in biopsy GS 3 + 3 patients. Then, a nomogram was developed to predict the probability of “unreal” GS 3 + 3 PCa according to the results of multivariate analysis. Finally, receiver operating characteristic and decision curve analysis (DCA) curves were structured to identify the efficiency of the predictive model. Compared to higher GS grade, biopsy GS 3 + 3 had greater upgrade risk (<i>P</i> &lt; 0.05) while a lower proportion of positive surgical margins, seminal vesicle invasion, extra-prostatic extension, lymph node invasion, and nerve invasion (all <i>P</i> &lt; 0.05). Multivariate analysis showed that age, PSAD, prostate imaging reporting and data system (PI-RADS) score and biopsy positive cores were significant risk factors for “unreal” GS 3 + 3. A nomogram was developed utilizing these factors with high prediction performance (area under curve = 0.924). Furthermore, DCA curve suggested that this predictive model was effective. The nomogram identified the probability of “unreal” GS 3 + 3 PCa in biopsy GS 3 + 3 PCa patients, which was of great value for clinical guidance in low risk PCa therapy.
DOI: 10.6084/m9.figshare.9943988.v1
title: How to Pick Out the “Unreal” Gleason 3 + 3 Patients: A Nomogram for More Precise Active Surveillance Protocol in Low-Risk Prostate Cancer in a Chinese Population

description: To develop a nomogram for selecting the “unreal” Gleason score (GS) 3 + 3 patients in biopsy GS 3 + 3 prostate cancer (PCa) patients. Patients who were newly diagnosed with PCa by biopsy and underwent radical prostatectomy in the First Affiliated Hospital of Nanjing Medical University from January 2009 to October 2018 were enrolled. Comparisons were made between GS 3 + 3 and higher grade PCa patients. Logistic regression analysis was performed to determine the risk factors for the “unreal” GS 3 + 3 PCa in biopsy GS 3 + 3 patients. Then, a nomogram was developed to predict the probability of “unreal” GS 3 + 3 PCa according to the results of multivariate analysis. Finally, receiver operating characteristic and decision curve analysis (DCA) curves were structured to identify the efficiency of the predictive model. Compared to higher GS grade, biopsy GS 3 + 3 had greater upgrade risk (<i>P</i> &lt; 0.05) while a lower proportion of positive surgical margins, seminal vesicle invasion, extra-prostatic extension, lymph node invasion, and nerve invasion (all <i>P</i> &lt; 0.05). Multivariate analysis showed that age, PSAD, prostate imaging reporting and data system (PI-RADS) score and biopsy positive cores were significant risk factors for “unreal” GS 3 + 3. A nomogram was developed utilizing these factors with high prediction performance (area under curve = 0.924). Furthermore, DCA curve suggested that this predictive model was effective. The nomogram identified the probability of “unreal” GS 3 + 3 PCa in biopsy GS 3 + 3 PCa patients, which was of great value for clinical guidance in low risk PCa therapy.
DOI: 10.48597/pyy8-xpkd
title: Measurement of Inorganics in precipitation at Irafoss

description: Measurement of Inorganics in precipitation at Irafoss
DOI: 10.48597/qkkq-b4wa
title: Measurement of Ammonia at Abastumani

description: Measurement of Ammonia at Abastumani
DOI: 10.48597/qy4n-fym8
title: Measurement of Sulphur_dioxide at Abastumani

description: Measurement of Sulphur_dioxide at Abastumani
DOI: 10.48597/rcf9-4n2q
title: Measurement of Conductivity at Eskdalemuir

description: Measurement of Conductivity at Eskdalemuir
DOI: 10.48597/rpus-ghwg
title: Measurement of Ammonium at Abastumani

description: Measurement of Ammonium at Abastumani
DOI: 10.48597/rtus-w5dm
title: Measurement of Chloride at Starina

description: Measurement of Chloride at Starina
DOI: 10.48597/sdfa-f822
title: Measurement of Magnesium at Eskdalemuir

description: Measurement of Magnesium at Eskdalemuir
DOI: 10.48597/sq7r-93n2
title: Measurement of Ammonium at Stará Lesná

description: Measurement of Ammonium at Stará Lesná
DOI: 10.48597/sysu-yr8z
title: Measurement of Potassium at Eskdalemuir

description: Measurement of Potassium at Eskdalemuir
DOI: 10.48597/u7a9-djkq
title: Measurement of Nitrate at Nuuk

description: Measurement of Nitrate at Nuuk
DOI: 10.48597/uasr-jj6p
title: Measurement of Conductivity at Chopok

description: Measurement of Conductivity at Chopok
DOI: 10.48597/upkm-tdtp
title: Measurement of Conductivity at Lough Navar

description: Measurement of Conductivity at Lough Navar
DOI: 10.48597/urky-7wmp
title: Measurement of Potassium at Amberd

description: Measurement of Potassium at Amberd
DOI: 10.48597/vcf6-hfhv
title: Measurement of Chloride at Stará Lesná

description: Measurement of Chloride at Stará Lesná
DOI: 10.48597/vdzy-6kr7
title: Measurement of Aerosol light scattering at Cape Point

description: Measurement of Aerosol light scattering at Cape Point
DOI: 10.48597/vh7v-bz9e
title: Measurement of Iron at Villum Research Station, Station Nord

description: Measurement of Iron at Villum Research Station, Station Nord
DOI: 10.48597/vrxe-n7z5
title: Measurement of Aerosol light scattering at Cape Point

description: Measurement of Aerosol light scattering at Cape Point
DOI: 10.48597/vt2d-vk8x
title: Measurement of Mercury at Zeppelin mountain (Ny-Ålesund)

description: Measurement of Mercury at Zeppelin mountain (Ny-Ålesund)
DOI: 10.48597/w4jz-hjyg
title: Measurement of Sulphate_corrected at Anholt

description: Measurement of Sulphate_corrected at Anholt
DOI: 10.48597/wh9v-jkv4
title: Measurement of Conductivity at Starina

description: Measurement of Conductivity at Starina
DOI: 10.6084/m9.figshare.6797867.v2
title: Involvement of prelimbic 5-HT<sub>7</sub> receptors in the regulation of anxiety-like behaviors in hemiparkinsonian rats

description: <b>Objective:</b> At present, little is known about the role of serotonin<sub>7</sub> (5-HT<sub>7</sub>) receptor in anxiety, particularly in Parkinson’s disease-related anxiety. Here, we tested whether 5-HT<sub>7</sub> receptors in the prelimbic (PrL) cortex are involved in the regulation of anxiety-like behaviors in sham-operated rats and rats with unilateral 6-hydroxydopamine lesions of the medial forebrain bundle (MFB). <b>Methods:</b> The open field and elevated plus maze (EPM) tests were performed to study the influence of MFB lesion and intra-PrL injection of 5-HT<sub>7</sub> agonist AS19 (0.5, 1 or 2 μg/rat) and antagonist SB269970 (1.5, 3 or 6 μg/rat) on anxiety-like behaviors. Additionally, changes in monoamine levels in limbic and limbic-related brain regions were observed after intra-PrL injection of AS19 (2 μg/rat) and SB269970 (6 μg/rat). <b>Results:</b> The MFB lesion induced anxiety-like behaviors compared to sham-operated rats. Intra-PrL injection of AS19 showed anxiolytic effects by the open field and EPM tests in two groups of rats, and administration of SB269970 showed anxiogenic responses. However, the doses producing these effects in the lesioned rats were higher than those in sham-operated rats. Neurochemical results showed that intra-PrL injection of AS19 increased dopamine, 5-HT and noradrenaline (NA) levels in the medial prefrontal cortex, ventral hippocampus and amygdala in two groups of rats, whereas SB269970 decreased 5-HT and NA levels in these brain regions. <b>Discussion:</b> 5-HT<sub>7</sub> receptors in the PrL are involved in the regulation of anxiety-like behaviors, which is attributable to changes in dopamine, 5-HT and NA levels in the limbic and limbic-related brain regions after activation and blockade of 5-HT<sub>7</sub> receptors. <b>Abbreviations:</b> 6-OHDA: 6-hydroxydopamine; DMSO: dimethyl sulfoxide; DA: dopamine; EPM: elevated plus maze; MFB: medial forebrain bundlem; PFC: medial prefrontal cortex; NA: noradrenaline; PD: Pakinson's disease; PrL: prelimbic; 5-HT: serotonin; vHip: ventral hippocampus
DOI: 10.48597/wmyn-hgjs
title: Measurement of Sodium at Eskdalemuir

description: Measurement of Sodium at Eskdalemuir
DOI: 10.6084/m9.figshare.17284032
title: Additional file 1 of CircIL4R activates the PI3K/AKT signaling pathway via the miR-761/TRIM29/PHLPP1 axis and promotes proliferation and metastasis in colorectal cancer

description: Additional file 1: Table S1. Clinical characteristics of 120 CRC samples used for qRT-PCR validation. Table S2. The sequences of siRNAs and shRNAs used in this study. Table S3. The sequences of primers used for qRT-PCR. Table S4. Relationship between circIL4R expression and clinicopathological features in fresh-frozen specimens. Table S5. Univariate Cox regression analysis of circIL4R expression and clinicopathologic variables predicting the survival of CRC patients. Table S6. Multivariate Cox regression analysis of circIL4R expression and clinicopathologic variables predicting the survival of CRC patients. Table S7. Prediction of miR-761 target genes based on four databases. Table S8. Relationship between circIL4R expression and clinicopathological features in TMAs specimens.
DOI: 10.6084/m9.figshare.17284032.v1
title: Additional file 1 of CircIL4R activates the PI3K/AKT signaling pathway via the miR-761/TRIM29/PHLPP1 axis and promotes proliferation and metastasis in colorectal cancer

description: Additional file 1: Table S1. Clinical characteristics of 120 CRC samples used for qRT-PCR validation. Table S2. The sequences of siRNAs and shRNAs used in this study. Table S3. The sequences of primers used for qRT-PCR. Table S4. Relationship between circIL4R expression and clinicopathological features in fresh-frozen specimens. Table S5. Univariate Cox regression analysis of circIL4R expression and clinicopathologic variables predicting the survival of CRC patients. Table S6. Multivariate Cox regression analysis of circIL4R expression and clinicopathologic variables predicting the survival of CRC patients. Table S7. Prediction of miR-761 target genes based on four databases. Table S8. Relationship between circIL4R expression and clinicopathological features in TMAs specimens.
DOI: 10.48597/x7av-kx9p
title: Measurement of Magnesium at Lough Navar

description: Measurement of Magnesium at Lough Navar
DOI: 10.48597/x9gr-xq36
title: Measurement of Chloride at Chopok

description: Measurement of Chloride at Chopok
DOI: 10.48597/xcrs-tcq9
title: Measurement of Chloride at Chopok

description: Measurement of Chloride at Chopok
DOI: 10.48597/y4qn-y85a
title: Measurement of Sulphate_total at Abastumani

description: Measurement of Sulphate_total at Abastumani
DOI: 10.48597/yeat-bsv3
title: Measurement of Precipitation_amount at Lough Navar

description: Measurement of Precipitation_amount at Lough Navar
DOI: 10.48597/zcgn-zkxs
title: Measurement of Sulphate_total at Stará Lesná

description: Measurement of Sulphate_total at Stará Lesná
DOI: 10.48597/zp5b-6z52
title: Measurement of Precipitation_amount at Irafoss

description: Measurement of Precipitation_amount at Irafoss
DOI: 10.48597/2q2q-cfvh
title: Particle_number_size_distribution at Kosetice (NOAK)

description: Measurement of Particle_number_size_distribution at Kosetice (NOAK)
DOI: 10.48597/zsft-s6wy
title: Measurement of Potassium at Amberd

description: Measurement of Potassium at Amberd
DOI: 10.48597/2xh3-ucqs
title: Particle_number_size_distribution at Kosetice (NOAK)

description: Measurement of Particle_number_size_distribution at Kosetice (NOAK)
DOI: 10.48597/3dnx-qvdz
title: Particle_number_size_distribution at Kosetice (NOAK)

description: Measurement of Particle_number_size_distribution at Kosetice (NOAK)
DOI: 10.48597/3syz-j3sg
title: Particle_number_size_distribution at Kosetice (NOAK)

description: Measurement of Particle_number_size_distribution at Kosetice (NOAK)
DOI: 10.48597/49pe-qmgf
title: Particle_number_size_distribution at Kosetice (NOAK)

description: Measurement of Particle_number_size_distribution at Kosetice (NOAK)
DOI: 10.48597/4mqc-mhwd
title: Particle_number_size_distribution at Kosetice (NOAK)

description: Measurement of Particle_number_size_distribution at Kosetice (NOAK)
DOI: 10.48597/4tvr-97hk
title: Particle_number_size_distribution at Kosetice (NOAK)

description: Measurement of Particle_number_size_distribution at Kosetice (NOAK)
DOI: 10.48597/4x3g-k6cf
title: Particle_number_size_distribution at Kosetice (NOAK)

description: Measurement of Particle_number_size_distribution at Kosetice (NOAK)
DOI: 10.48597/5cxf-kp8x
title: Particle_number_size_distribution at Kosetice (NOAK)

description: Measurement of Particle_number_size_distribution at Kosetice (NOAK)
DOI: 10.48597/5ece-ebzz
title: Particle_number_size_distribution at Kosetice (NOAK)

description: Measurement of Particle_number_size_distribution at Kosetice (NOAK)
DOI: 10.48597/5exg-buu3
title: Particle_number_size_distribution at Kosetice (NOAK)

description: Measurement of Particle_number_size_distribution at Kosetice (NOAK)
DOI: 10.48597/5k5a-cm5t
title: Particle_number_size_distribution at Kosetice (NOAK)

description: Measurement of Particle_number_size_distribution at Kosetice (NOAK)
DOI: 10.48597/5tw3-s6at
title: Particle_number_size_distribution at Kosetice (NOAK)

description: Measurement of Particle_number_size_distribution at Kosetice (NOAK)
DOI: 10.48597/64v7-znvb
title: Particle_number_size_distribution at Kosetice (NOAK)

description: Measurement of Particle_number_size_distribution at Kosetice (NOAK)
DOI: 10.48597/6vjw-2f89
title: Particle_number_size_distribution at Kosetice (NOAK)

description: Measurement of Particle_number_size_distribution at Kosetice (NOAK)
DOI: 10.48597/6wfv-ysxs
title: Particle_number_size_distribution at Kosetice (NOAK)

description: Measurement of Particle_number_size_distribution at Kosetice (NOAK)
DOI: 10.48597/6y8z-ut49
title: Particle_number_size_distribution at Kosetice (NOAK)

description: Measurement of Particle_number_size_distribution at Kosetice (NOAK)
DOI: 10.48597/73gc-hrr2
title: Particle_number_size_distribution at Kosetice (NOAK)

description: Measurement of Particle_number_size_distribution at Kosetice (NOAK)
DOI: 10.48597/74z9-4279
title: Particle_number_size_distribution at Kosetice (NOAK)

description: Measurement of Particle_number_size_distribution at Kosetice (NOAK)
DOI: 10.48597/7cmb-bfx3
title: Particle_number_size_distribution at Kosetice (NOAK)

description: Measurement of Particle_number_size_distribution at Kosetice (NOAK)
DOI: 10.48597/965a-d5mr
title: Particle_number_size_distribution at Kosetice (NOAK)

description: Measurement of Particle_number_size_distribution at Kosetice (NOAK)
DOI: 10.48597/9phb-smyy
title: Particle_number_size_distribution at Kosetice (NOAK)

description: Measurement of Particle_number_size_distribution at Kosetice (NOAK)
DOI: 10.48597/9psa-x2h4
title: Particle_number_size_distribution at Kosetice (NOAK)

description: Measurement of Particle_number_size_distribution at Kosetice (NOAK)
DOI: 10.48597/9ttd-ejpz
title: Particle_number_size_distribution at Kosetice (NOAK)

description: Measurement of Particle_number_size_distribution at Kosetice (NOAK)
DOI: 10.48597/a8a6-255w
title: Particle_number_size_distribution at Kosetice (NOAK)

description: Measurement of Particle_number_size_distribution at Kosetice (NOAK)
DOI: 10.48597/as9r-uqbz
title: Particle_number_size_distribution at Kosetice (NOAK)

description: Measurement of Particle_number_size_distribution at Kosetice (NOAK)
DOI: 10.48597/bg5q-x5rq
title: Particle_number_size_distribution at Kosetice (NOAK)

description: Measurement of Particle_number_size_distribution at Kosetice (NOAK)
DOI: 10.48597/brap-kvma
title: Particle_number_size_distribution at Kosetice (NOAK)

description: Measurement of Particle_number_size_distribution at Kosetice (NOAK)
DOI: 10.48597/cauz-ke3k
title: Particle_number_size_distribution at Kosetice (NOAK)

description: Measurement of Particle_number_size_distribution at Kosetice (NOAK)
DOI: 10.48597/cbdq-7vaj
title: Particle_number_size_distribution at Kosetice (NOAK)

description: Measurement of Particle_number_size_distribution at Kosetice (NOAK)
DOI: 10.48597/cpee-5m8v
title: Particle_number_size_distribution at Kosetice (NOAK)

description: Measurement of Particle_number_size_distribution at Kosetice (NOAK)
DOI: 10.48597/d3yp-aeyq
title: Particle_number_size_distribution at Kosetice (NOAK)

description: Measurement of Particle_number_size_distribution at Kosetice (NOAK)
DOI: 10.48597/d3zk-4qaf
title: Particle_number_size_distribution at Kosetice (NOAK)

description: Measurement of Particle_number_size_distribution at Kosetice (NOAK)
DOI: 10.48597/dcke-ahtj
title: Particle_number_size_distribution at Kosetice (NOAK)

description: Measurement of Particle_number_size_distribution at Kosetice (NOAK)
DOI: 10.48597/dgwm-x2t2
title: Particle_number_size_distribution at Kosetice (NOAK)

description: Measurement of Particle_number_size_distribution at Kosetice (NOAK)
DOI: 10.48597/dyx9-vxu5
title: Particle_number_size_distribution at Kosetice (NOAK)

description: Measurement of Particle_number_size_distribution at Kosetice (NOAK)
DOI: 10.48597/emkq-wq6s
title: Particle_number_size_distribution at Kosetice (NOAK)

description: Measurement of Particle_number_size_distribution at Kosetice (NOAK)
DOI: 10.48597/eqym-b2s6
title: Particle_number_size_distribution at Kosetice (NOAK)

description: Measurement of Particle_number_size_distribution at Kosetice (NOAK)
DOI: 10.48597/f6sv-jctc
title: Particle_number_size_distribution at Kosetice (NOAK)

description: Measurement of Particle_number_size_distribution at Kosetice (NOAK)
DOI: 10.48597/f8ct-ufsg
title: Particle_number_size_distribution at Kosetice (NOAK)

description: Measurement of Particle_number_size_distribution at Kosetice (NOAK)