cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.28451015
title: Supplementary Material for: Identification of potential diagnostic biomarkers and drug targets for endometriosis from a genetic perspective: a mendelian randomization study

description: Introduction: Endometriosis (EM) is a chronic disease severely impacting reproductive health, with its exact cause still unclear. In-depth understanding of the etiology and pathogenesis of EM from the perspective of genetics and exploring individualized treatment strategies can improve the health and quality of life of patients.
Methods: In this study, whole blood cis- expression quantitative trait loci (eQTL) data were used as exposure data, and data from the FinnGen database EM1-2 and EM3-4 were used as outcomes. Summary-data-based mendelian randomization (SMR) methods were used to select genes with causal relationship to the disease. These genes were validated through bioinformatics analysis and real-time quantitative polymerase chain reaction (RT-qPCR) analysis of clinical samples, and potential diagnostic and drug targets were screened through co-localization and molecular docking.
Results: Through SMR analysis, seven genes were selected as potential diagnostic markers of EM, namely Eukaryotic Elongation Factor, Selenocysteine-TRNA Specific (EEFSEC), INO80 complex subunit E (INO80E), RAP1 GTPase activating protein (RAP1GAP), Lipid Droplet Associated Hydrolase (LDAH), Ring Finger And SPRY Domain Containing 1 (RSPRY1), HLA Complex Group 22 (Non-Protein Coding) (HCG22) and Adenosine Kinase (ADK). Colocalization analysis showed that EEFSEC, HCG22, INO80E and RSPRY1 could be used as potential drug targets.
Conclusions: The study identifies potential diagnostic markers and drug targets for EM from a genetic perspective, providing new directions for drug development and precision medicine for EM treatment.
DOI: 10.6084/m9.figshare.28451027
title: Supplementary Material for: Clinical characteristics of women with surgical signs of superficial peritoneal endometriosis but a negative histology: A nested case-control study

description: Objectives: To investigate the clinical characteristics of women with superficial peritoneal endometriosis (SUP) diagnosed by surgery and not confirmed by histology, compared with histologically proven SUP.
Design: Single-center, nested case-control study.
Participants/Materials: Patients with a surgical report of SUP (n = 390), comprising a subgroup with histological confirmation of endometriosis (n = 245) and a subgroup without it (n = 145). In addition, we enrolled a control group (n = 390) among non-pregnant patients submitted to a laparoscopy or laparotomy for a benign gynecologic condition without any macroscopic sign of endometriosis.
Setting: University hospital.
Methods: Data synthesis, descriptive statistics, chi-square test and one-way analysis of variance followed by Tukey’s test.
Results: All groups had similar age, body mass index, smoking prevalence, serum AMH levels and menstrual cycle patterns. However, the two SUP subgroups had the same prevalence and intensity of endometriosis symptoms. The SUP/histology-negative subgroup was more likely to have a familial history of endometriosis (14% vs. 1%) or a personal history of primary infertility (29% vs. 19%) or primary dysmenorrhea (50% vs. 33%) compared to the control group (all p values &lt;0.01). The intensity scores for dysmenorrhea, deep dyspareunia and non-cyclic chronic pelvic pain were severer in both SUP subgroups than in the control group (p&lt;0.05).
Limitations: The participants underwent surgery, so their symptoms may not represent groups with initial or mild disease that responded to medical treatments. Due to the retrospective design, performance bias cannot be ruled out.
Conclusions: Patients with suspected SUP lesions and a negative histology had clinical characteristics resembling those with proven endometriosis. Further characterization with molecular biomarkers is needed to explain why these women are so symptomatic in the absence of histological hallmarks of the disease.
DOI: 10.6084/m9.figshare.28451027.v1
title: Supplementary Material for: Clinical characteristics of women with surgical signs of superficial peritoneal endometriosis but a negative histology: A nested case-control study

description: Objectives: To investigate the clinical characteristics of women with superficial peritoneal endometriosis (SUP) diagnosed by surgery and not confirmed by histology, compared with histologically proven SUP.
Design: Single-center, nested case-control study.
Participants/Materials: Patients with a surgical report of SUP (n = 390), comprising a subgroup with histological confirmation of endometriosis (n = 245) and a subgroup without it (n = 145). In addition, we enrolled a control group (n = 390) among non-pregnant patients submitted to a laparoscopy or laparotomy for a benign gynecologic condition without any macroscopic sign of endometriosis.
Setting: University hospital.
Methods: Data synthesis, descriptive statistics, chi-square test and one-way analysis of variance followed by Tukey’s test.
Results: All groups had similar age, body mass index, smoking prevalence, serum AMH levels and menstrual cycle patterns. However, the two SUP subgroups had the same prevalence and intensity of endometriosis symptoms. The SUP/histology-negative subgroup was more likely to have a familial history of endometriosis (14% vs. 1%) or a personal history of primary infertility (29% vs. 19%) or primary dysmenorrhea (50% vs. 33%) compared to the control group (all p values &lt;0.01). The intensity scores for dysmenorrhea, deep dyspareunia and non-cyclic chronic pelvic pain were severer in both SUP subgroups than in the control group (p&lt;0.05).
Limitations: The participants underwent surgery, so their symptoms may not represent groups with initial or mild disease that responded to medical treatments. Due to the retrospective design, performance bias cannot be ruled out.
Conclusions: Patients with suspected SUP lesions and a negative histology had clinical characteristics resembling those with proven endometriosis. Further characterization with molecular biomarkers is needed to explain why these women are so symptomatic in the absence of histological hallmarks of the disease.
DOI: 10.6084/m9.figshare.28451033
title: Supplementary Material for: ​​​Cardiovascular Safety of GnRH Agonist-Based Androgen Deprivation Therapy in a Real-World Setting: Results from a Prospective Cohort Study (LEAN)

description: Introduction: LEAN is a prospective, multicenter, noninterventional, German cohort study in patients with locally advanced and metastatic hormone-sensitive prostate cancer (PC). This analysis explores the efficacy and safety of leuprorelin in patients with PC and an indication for androgen deprivation therapy (ADT) in routine practice. 
Methods: Safety assessment focused on the incidence of major adverse cardiovascular (CV) events (MACEs; a composite of all-cause death, myocardial infarction, or stroke) over the 12-month study period. Patients initiating ADT before enrollment were excluded from the analysis. 
Results: Of the 1,372 patients included, MACEs occurred in 57 (4.2%) patients, and in 18/532 (3.4%) versus 39/840 (4.6%) patients without and with a pre-existing CV comorbidity, respectively (p=0.264). Of the 57 MACEs, 17 were CV events and 20 were considered PC related events; in 20 patients, events were classed as ‘other’ or the context remained unknown. Only one MACE, nonserious arrhythmia, was considered drug related by the urologist. Of the 51 deaths reported in patients with MACEs, 12 were related to a CV event and 20 were related to disease progression. 
Conclusion: In a large European patient cohort, leuprorelin-based ADT demonstrated an acceptable safety profile, with a low incidence of CV events.
DOI: 10.15468/dl.7epyvn
title: Occurrence Download

description: A dataset containing 3052 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is India",
 "TaxonKey is Toona ciliata M.Roem."
 ]
}

 The dataset includes 3052 records from 33 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0003143-250218110819086/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.6084/m9.figshare.28451033.v1
title: Supplementary Material for: ​​​Cardiovascular Safety of GnRH Agonist-Based Androgen Deprivation Therapy in a Real-World Setting: Results from a Prospective Cohort Study (LEAN)

description: Introduction: LEAN is a prospective, multicenter, noninterventional, German cohort study in patients with locally advanced and metastatic hormone-sensitive prostate cancer (PC). This analysis explores the efficacy and safety of leuprorelin in patients with PC and an indication for androgen deprivation therapy (ADT) in routine practice. 
Methods: Safety assessment focused on the incidence of major adverse cardiovascular (CV) events (MACEs; a composite of all-cause death, myocardial infarction, or stroke) over the 12-month study period. Patients initiating ADT before enrollment were excluded from the analysis. 
Results: Of the 1,372 patients included, MACEs occurred in 57 (4.2%) patients, and in 18/532 (3.4%) versus 39/840 (4.6%) patients without and with a pre-existing CV comorbidity, respectively (p=0.264). Of the 57 MACEs, 17 were CV events and 20 were considered PC related events; in 20 patients, events were classed as ‘other’ or the context remained unknown. Only one MACE, nonserious arrhythmia, was considered drug related by the urologist. Of the 51 deaths reported in patients with MACEs, 12 were related to a CV event and 20 were related to disease progression. 
Conclusion: In a large European patient cohort, leuprorelin-based ADT demonstrated an acceptable safety profile, with a low incidence of CV events.
DOI: 10.15468/dl.n3dwcj
title: Occurrence Download

description: A dataset containing 15 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Cephalorhynchus eutropia (Gray, 1846)",
 "HasCoordinate is true",
 "DecimalLatitude is greater than -90",
 "DecimalLongitude is greater than -180",
 "OccurrenceStatus is Present",
 "Year is greater than or equal to 1950",
 "Year is less than or equal to 2014"
 ]
}

 The dataset includes 15 records from 6 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0003144-250218110819086/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.6084/m9.figshare.28451042
title: Supplementary Material for: Non-Metastatic Pure Pancreatic Hepatoid Carcinoma With Genomic and Transcriptomic Analysis: A Case Report

description: Background: Pancreatic hepatoid carcinoma (PHC) is a rare and poorly characterized malignancy, with approximately 50 reported cases in the literature. Pure pancreatic hepatoid carcinoma, which lacks any features of adenocarcinoma or neuroendocrine differentiation, is a subset of this population and is extremely rare. Data on its management and genomic findings are limited, and further characterization may provide helpful information in caring for these patients. Case Presentation: A 42-year-old female who was found to have a large, well-circumscribed mass in the body of the pancreas with elevated serum alpha-fetoprotein. Imaging demonstrated an 8.5 cm pancreatic lesion with no other disease. Endoscopic ultrasound-guided biopsy revealed a bile-producing carcinoma with morphological and immunohistochemical features consistent with hepatocellular carcinoma. She underwent a subtotal pancreatectomy and splenectomy, and pathologic evaluation confirmed a well-differentiated pure pancreatic hepatoid carcinoma confined to the pancreas. Whole genome and transcriptome analysis showed microsatellite stability, an elevated tumour mutation burden, copy number alterations in Chr19p13.3 and no mutations typically seen in pancreatic ductal adenocarcinoma (PDAC). These findings support the diagnosis of a pure hepatoid carcinoma with clinical, histopathological, and genomic characteristics resembling hepatocellular carcinoma. She remains disease-free at nine months without adjuvant therapy. Conclusion: This case demonstrates further characterization of a rare pancreatic lesion and illustrates the importance of integrated histopathological and genomic analyses in characterizing rare malignancies. Additionally, our findings suggest that pure PHC may be a distinct entity, rather than a variant of PDAC.
DOI: 10.6084/m9.figshare.28451042.v1
title: Supplementary Material for: Non-Metastatic Pure Pancreatic Hepatoid Carcinoma With Genomic and Transcriptomic Analysis: A Case Report

description: Background: Pancreatic hepatoid carcinoma (PHC) is a rare and poorly characterized malignancy, with approximately 50 reported cases in the literature. Pure pancreatic hepatoid carcinoma, which lacks any features of adenocarcinoma or neuroendocrine differentiation, is a subset of this population and is extremely rare. Data on its management and genomic findings are limited, and further characterization may provide helpful information in caring for these patients. Case Presentation: A 42-year-old female who was found to have a large, well-circumscribed mass in the body of the pancreas with elevated serum alpha-fetoprotein. Imaging demonstrated an 8.5 cm pancreatic lesion with no other disease. Endoscopic ultrasound-guided biopsy revealed a bile-producing carcinoma with morphological and immunohistochemical features consistent with hepatocellular carcinoma. She underwent a subtotal pancreatectomy and splenectomy, and pathologic evaluation confirmed a well-differentiated pure pancreatic hepatoid carcinoma confined to the pancreas. Whole genome and transcriptome analysis showed microsatellite stability, an elevated tumour mutation burden, copy number alterations in Chr19p13.3 and no mutations typically seen in pancreatic ductal adenocarcinoma (PDAC). These findings support the diagnosis of a pure hepatoid carcinoma with clinical, histopathological, and genomic characteristics resembling hepatocellular carcinoma. She remains disease-free at nine months without adjuvant therapy. Conclusion: This case demonstrates further characterization of a rare pancreatic lesion and illustrates the importance of integrated histopathological and genomic analyses in characterizing rare malignancies. Additionally, our findings suggest that pure PHC may be a distinct entity, rather than a variant of PDAC.
DOI: 10.6084/m9.figshare.28451045
title: Supplementary Material for: The Role of Artificial Intelligence in Gynecologic Oncology Decision Making: A Feasibility Study

description: Objective: To examine the potential of artificial intelligence (AI) in gynecologic oncology decision making.
Design: Feasibility study.
Setting: Fictive.
Participants: Fictitious case vignettes of gynecologic carcinomas.
Methods: Fictitious case vignettes of gynecologic carcinomas were created and evaluated by physicians with varying levels of professional experience, as well as by language models including Chat-GPT 4.0, Google Gemini, and Bing-Copilot. Treatment approval decisions were based on standardized clinical and laboratory criteria. 
Results: Two cases of breast cancer, one case of ovarian cancer, one case of cervical cancer and one case of endometrial cancer were evaluated. All three language models were able to evaluate all clinical cases and make therapy-relevant suggestions, with Chat-GPT providing the most clear and concise recommendations that were in three cases totally consistent with physician assessments.
Conclusions: The study demonstrates that AI models, such as Chat-GPT, can to some extent evaluate clinical cases, recognize clinical and/or laboratory abnormalities and make therapy-related suggestions. Despite high overall agreement, differences were predominantly noted in the more complex cases, rendering human interpretation necessary. The findings underscore the benefits of AI in terms of clarity, time efficiency, and cost-effectiveness. Future research should further explore the application of AI to real patient data and development of hybrid decision models to optimize integration into clinical practice.
Limitations: Feasibility study with five fictitious case vignettes.
DOI: 10.6084/m9.figshare.28451048
title: Supplementary Material for: Development of fall risk classification models for community-dwelling older adults using latent class analysis and machine learning

description: Introduction: To identify fall risk groups among community-dwelling older adults in South Korea and build a classification model by investigating risk-associated factors.
Methods: This cross-sectional study analyzed data of 9,231 older adults from the the 2020 Elderly Survey. We used latent class analysis to identify fall risk groups based on fall indicators. Thereafter, classification models were developed with these identified groups as outcome variables.
Results: Latent class analysis results indicated that a three-class model was more interpretable and fit the data better than other models. Among the models, the XGBoost algorithm displayed superior performance (accuracy = 0.70, precision = 0.69, recall = 0.70, F1-score = 0.68). Key variables associated with fall risk groups included self-rated health, cognitive function, recent healthcare use, and assistance needed in instrumental activities of daily living.
Conclusion: The study adopted a preventive approach by differentiating among low-, moderate-, and high-fall-risk groups, thus providing valuable insights for healthcare professionals. Identifying these risk factors can support the development of customized fall prevention programs for older adults.
DOI: 10.6084/m9.figshare.28451051.v1
title: Supplementary Material for: Benign recurrent intrahepatic cholestasis type 1 with novel gene mutation complicated by distal renal tubular acidosis: a case report

description: Introduction: Benign recurrent intrahepatic cholestasis (BRIC) is a rare autosomal recessive inherited disorder characterized by intermittent jaundice episodes. Case presentation: We report a 25-year-old male patient with numerous hospitalizations for jaundice. The diagnosis of BRIC type 1 was established by liver biopsy, genetic analysis, and the exclusion of alternative etiologies of cholestasis. A novel missense heterozygous variant was identified in the ATP8B1 gene (c.2081T&gt;A). The acute cholestatic attack, along with associated complications such as distal renal tubular acidosis and acute pancreatitis, were successfully managed with plasmapheresis and rifampicin. Conclusion: Novel mutations that differ from those documented in the literature in combination with renal tubular acidosis may enhance our comprehension of this topic.
DOI: 10.15468/dl.m3mwdt
title: Occurrence Download

description: A dataset containing 174 species occurrences available in GBIF matching the query:
{
 "and" : [
 "GadmGid is DEU.3_1",
 "OccurrenceStatus is Present",
 "TaxonKey is Araschnia levana (Linnaeus, 1758)"
 ]
}

 The dataset includes 174 records from 11 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0003145-250218110819086/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.6084/m9.figshare.28451054
title: Supplementary Material for: A case: Thrombocytopenia in an EGFR 19 exon-deficient bilateral diffuse LUAD with ARDS treated with ECMO and Osimertinib

description: Introduction: EGFR-sensitive mutations bilateral-diffuse lung adenocarcinoma (LUAD) complicated with acute respiratory distress syndrome (ARDS)is relatively rare. Whether EGFR-TKI can be simultaneously received when treating with extracorporeal membrane oxygenation (ECMO) and anti-infective therapy in these patients, and what adverse events should be noted? 
Case Presentation: We report a case of EGFR 19 exon-deficient bilateral diffuse LUAD complicated with ARDS. When treated with ECMO and anti-infective therapy, the patient received oral Osimertinib anti-tumor therapy simultaneously. The tumor receded, but eventually irreversible thrombocytopenia developed.
Conclusion: For patients with severe lung cancer, anti-tumor efficacy and adverse events should be closely observed during anti-tumor therapy.
DOI: 10.6084/m9.figshare.28451057
title: Supplementary Material for: A prognostic index for deceased donor kidneys and criteria for identifying suitable candidates for kidney transplantation from expanded criteria donors with prolonged waiting times

description: Introduction: The kidney donor profile index (KDPI) is a valuable prognostic tool in deceased donor kidney transplantation (DDKT), while its optimization for each country using local data is essential. It remains unclear which patients derive survival benefits from expanded criteria donor (ECD) DDKT compared to waitlist or standard criteria donor (SCD) DDKT, particularly in the context of long waiting times. This study aims to develop a prognostic index for donor kidneys and propose criteria to identify suitable candidates for ECD DDKT in Korea.
Methods: Two prediction models were developed using data from two cohorts based on national databases (the Korean Network for Organ Sharing and the National Health Insurance Data Sharing Service): cohort for the prediction of graft prognosis (n=6,272) and cohort for the prediction of suitable candidates for ECD DDKT (n=30,183).
Results: The Korean KDPI (K-KDPI) comprises five donor factors (age, height, diabetes mellitus, serum creatinine levels, and hepatitis C virus), associated with graft failure. The discriminatory ability of the K-KDPI for graft outcomes surpassed that of the US KDPI and dichotomous ECD criteria. ECD kidneys (K-KDPI ≥70%) showed worse allograft survival compared to SCD kidneys (K-KDPI &lt;70%). Candidates aged ≥40 years, with negative panel reactive antibody, and without diabetes mellitus had a significantly lower mortality risk with ECD DDKT than with waitlist-or-SCD DDKT, making them suitable for ECD DDKT.
Conclusion: The K-KDPI and criteria for identifying suitable ECD recipients are expected to improve the quality assessment and efficient utilization of ECD kidneys in Korea with long waiting times.
DOI: 10.6084/m9.figshare.28451057.v1
title: Supplementary Material for: A prognostic index for deceased donor kidneys and criteria for identifying suitable candidates for kidney transplantation from expanded criteria donors with prolonged waiting times

description: Introduction: The kidney donor profile index (KDPI) is a valuable prognostic tool in deceased donor kidney transplantation (DDKT), while its optimization for each country using local data is essential. It remains unclear which patients derive survival benefits from expanded criteria donor (ECD) DDKT compared to waitlist or standard criteria donor (SCD) DDKT, particularly in the context of long waiting times. This study aims to develop a prognostic index for donor kidneys and propose criteria to identify suitable candidates for ECD DDKT in Korea.
Methods: Two prediction models were developed using data from two cohorts based on national databases (the Korean Network for Organ Sharing and the National Health Insurance Data Sharing Service): cohort for the prediction of graft prognosis (n=6,272) and cohort for the prediction of suitable candidates for ECD DDKT (n=30,183).
Results: The Korean KDPI (K-KDPI) comprises five donor factors (age, height, diabetes mellitus, serum creatinine levels, and hepatitis C virus), associated with graft failure. The discriminatory ability of the K-KDPI for graft outcomes surpassed that of the US KDPI and dichotomous ECD criteria. ECD kidneys (K-KDPI ≥70%) showed worse allograft survival compared to SCD kidneys (K-KDPI &lt;70%). Candidates aged ≥40 years, with negative panel reactive antibody, and without diabetes mellitus had a significantly lower mortality risk with ECD DDKT than with waitlist-or-SCD DDKT, making them suitable for ECD DDKT.
Conclusion: The K-KDPI and criteria for identifying suitable ECD recipients are expected to improve the quality assessment and efficient utilization of ECD kidneys in Korea with long waiting times.