cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.5281/zenodo.5772485
title: Classification of land cover for Selenga Basin -Buryat Republic, Russia and Mongolia, 1990, 2020.V1.3

description: !Readme
Classification of land cover for Selenga Basin -Buryat Republic, Russia and Mongolia, 1990, 2020.
Image classifications were performed in the Google Earth Engine environment. Pixel-based image composites were produced with Landsat 4,5 for the period I (1988-1991) and ESA Copernicus Sentinel-2 for period II (2019-2020). Original bands were complemented with simple seasonality metrics (e.g., minimum, maximum, standard deviation) calculated across phenology periods (from April to October). Training and validation data were collected during the field trip, interpretation of very-high-resolution imagery and dense optical Landsat and Sentinel-2.
Selenga_basin_1990_cl_v1.3.tif-image classification for Buryat (Russia) and Mongolian part of Selenga basin circa 1990
Selenga_basin_2020_cl_v1.3.tif-image classification for Buryat (Russia) and Mongolian part of Selenga basin circa 2020
Classification catalog
1-Forest
2-Cropland
3-Grassland
4-Impervious, bare
5-Water
For more details, please consult Alexander Prishchepov alpr@ign.ku.dk, prialign@gmail.com
DOI: 10.5281/zenodo.5772486
title: Classification of land cover for Selenga Basin -Buryat Republic, Russia and Mongolia, 1990, 2020.V1.3

description: !Readme
Classification of land cover for Selenga Basin -Buryat Republic, Russia and Mongolia, 1990, 2020.
Image classifications were performed in the Google Earth Engine environment. Pixel-based image composites were produced with Landsat 4,5 for the period I (1988-1991) and ESA Copernicus Sentinel-2 for period II (2019-2020). Original bands were complemented with simple seasonality metrics (e.g., minimum, maximum, standard deviation) calculated across phenology periods (from April to October). Training and validation data were collected during the field trip, interpretation of very-high-resolution imagery and dense optical Landsat and Sentinel-2.
Selenga_basin_1990_cl_v1.3.tif-image classification for Buryat (Russia) and Mongolian part of Selenga basin circa 1990
Selenga_basin_2020_cl_v1.3.tif-image classification for Buryat (Russia) and Mongolian part of Selenga basin circa 2020
Classification catalog
1-Forest
2-Cropland
3-Grassland
4-Impervious, bare
5-Water
For more details, please consult Alexander Prishchepov alpr@ign.ku.dk, prialign@gmail.com
DOI: 10.6084/m9.figshare.7375091
title: Additional file 2: of The genome of the water strider Gerris buenoi reveals expansions of gene repertoires associated with adaptations to life on the water

description: List of annotated autophagy genes in Gerris buenoi. (XLSX 12 kb)
DOI: 10.6084/m9.figshare.7376054
title: Designing multifunctional cancer-targeted nanosystem for magnetic resonance molecular imaging-guided theranostics of lung cancer

description: The integration of diagnosis and therapy is an effective way to improve therapeutic effects for cancer patients, which has acquired widely attentions from researchers. Herein, a multifunctional drug-loaded nanosystem (F/A-PLGA@DOX/SPIO) has been designed and synthesized to reduce the side effects of traditional chemotherapy drugs and realize simultaneous tumor diagnosis and treatment. The surface modification of folic acid (FA) and activatable cell-penetrating peptide (ACPP) endows the nanosystem with excellent cancer targeting capabilities, thus reducing toxicity to normal organs. Besides, the F/A-PLGA@DOX/SPIO nanosystem can serve as an excellent magnetic resonance imaging (MRI) <i>T<sub>2</sub></i>-negative contrast agent. More importantly, according to <i>in vitro</i> experiments, the F/A-PLGA@DOX/SPIO nanosystem can promote the overproduction of reactive oxygen species (ROS) within A549 lung cancer cells, inducing cell apoptosis, greatly enhancing the antineoplastic effect. Furthermore, with the help of MRI technology, the targeting imaging of the F/A-PLGA@DOX/SPIO nanosystem within tumors and the dynamic monitoring of medicine efficacy can be realized. Therefore, this study provided a multifunctional drug-loaded F/A-PLGA@DOX/SPIO targeted nanosystem for magnetic resonance molecular imaging-guided theranostics, which has excellent potential for the application in tumor diagnosis and therapy.
DOI: 10.6084/m9.figshare.7376054.v1
title: Designing multifunctional cancer-targeted nanosystem for magnetic resonance molecular imaging-guided theranostics of lung cancer

description: The integration of diagnosis and therapy is an effective way to improve therapeutic effects for cancer patients, which has acquired widely attentions from researchers. Herein, a multifunctional drug-loaded nanosystem (F/A-PLGA@DOX/SPIO) has been designed and synthesized to reduce the side effects of traditional chemotherapy drugs and realize simultaneous tumor diagnosis and treatment. The surface modification of folic acid (FA) and activatable cell-penetrating peptide (ACPP) endows the nanosystem with excellent cancer targeting capabilities, thus reducing toxicity to normal organs. Besides, the F/A-PLGA@DOX/SPIO nanosystem can serve as an excellent magnetic resonance imaging (MRI) <i>T<sub>2</sub></i>-negative contrast agent. More importantly, according to <i>in vitro</i> experiments, the F/A-PLGA@DOX/SPIO nanosystem can promote the overproduction of reactive oxygen species (ROS) within A549 lung cancer cells, inducing cell apoptosis, greatly enhancing the antineoplastic effect. Furthermore, with the help of MRI technology, the targeting imaging of the F/A-PLGA@DOX/SPIO nanosystem within tumors and the dynamic monitoring of medicine efficacy can be realized. Therefore, this study provided a multifunctional drug-loaded F/A-PLGA@DOX/SPIO targeted nanosystem for magnetic resonance molecular imaging-guided theranostics, which has excellent potential for the application in tumor diagnosis and therapy.
DOI: 10.6084/m9.figshare.13143233
title: An Extended Youden Design in Biological Assays

description: Cell-based biological assays (also called bioassays) are an essential analytical tool used for quality assessment of biologic drug substances and drug products. In particular, they are used to determine the potency compared against a standard preparation under assumptions of similarity. In the design of bioassays, orthogonality between preparations and nuisance factors is desired. Block designs are an efficient way to assay multiple preparations simultaneously and mitigate bias from multiple sources, such as plates, locations within plates, and operators. The construction of a block design of a bioassay is challenging because of the treatment/control setup and the presence of multiple block effects. In many cases, absolute orthogonality is not feasible, and consequently, we need a design that achieves “near-orthogonality.” We propose an extended Youden design with mathematical construction such that near-orthogonality can be achieved in the presence of these multiple confounding effects. We also provide an efficient algorithm implementation with R. Numerical results show that the extended Youden design is the optimal design for the given scenario when absolute orthogonality is not achievable.
DOI: 10.6084/m9.figshare.8424950
title: An atlas of chromatin accessibility and transcriptional changes in BmNPV infected Bombyx mori cells

description: A comprehensive information of ATAC-seq and RNA-seq datasets in BmNPV infected Bombyx mori cells is significant for understanding the host response to DNA virus infection in chromatin accessibility and gene expression. Here, we describe the ATAC-seq data FastQC reports, fragments length, reads enrichment around transcription start sites, and correlation between biological replicates indicated the reliable quality of the ATAC-seq dataset. Meanwhile, the RNA-seq data FastQC reports, reproducibility between replicates, differential expressed gene profiles, and count matrix were also demonstrated the high quality of the RNA-seq dataset.
DOI: 10.24403/jp.1338590
title: Kritische Revision der „Thlaspi“-Arten Europas, Afrikas und Vorderasiens. Spezieller Teil : I. Thlaspi L. / Friedrich Karl Meyer
DOI: 10.24403/jp.1338591
title: Kritische Revision der „Thlaspi“-Arten Europas, Vorderasiens und Afrikas. Spezieller Teil : II. Neurotropis (DC.) / Friedrich Karl Meyer
DOI: 10.6084/m9.figshare.25151639
title: Data and code files for paper "Ageing Gut-Brain Interactions: Proinflammatory gut bacteria are elevated in fecal samples from individuals living with Alzheimer’s dementia"

description: Alzheimer’s disease (AD) is the most common form of global dementia, characterized by an irreversible decline in cognitive function. The pathogenesis of several neurodegenerative disorders has been linked to dysbiosis of the gut microbiota through the gut-brain axis. We set out to establish by case-control study methodology whether there were any differences in the composition and/or function of the gut microbiota between older adults resident in care homes with or without an AD diagnosis.Based on the results of 16S rRNA gene profiling we established that AD sufferers had increased levels of <i>Escherichia/Shigella</i> and <i>Clostridium_sensu_stricto_1</i>, and decreased levels of <i>Bacteroides, Faecalibacterium, Blautia</i> and <i>Roseburia</i> species. The increased levels of potentially pro-inflammatory bacteria were consistent with slightly higher concentrations of calprotectin, a biomarker of gut inflammation. Levels of most microbial metabolites measured were similar across groups, although participants with AD had significantly increased proportions of the branched chain fatty acid, iso-butyrate and a decreased proportion of the specific short-chain fatty acid butyrate. Taken together these results show that participants with Alzheimer’s disease have several key differences within their gut microbiota profile, in contrast to care-home residents with no Alzheimer’s disease. The dysbiotic microbiome included both compositional and functional changes linked to poorer health and gut inflammation.
DOI: 10.24403/jp.1338623
title: Miscellanea hepaticologica 291-300 / Riclef Grolle
DOI: 10.25345/c59c6sb87
title: MassIVE MSV000094024 - A Salmonella subset subverts SLC11A1-imposed iron restriction by targeting red blood cell-degrading macrophages
title: This dataset comprises the raw data, metadata, the databases searched against in the analysis of this dataset, and the output file generated from the used search engine (SpectroNaut).
DOI: 10.24403/jp.1338633
title: Diplasiolejeunea pluridentata (Lejeuneaceae, Marchantiopsida), eine neue Art aus Costa Rica / Alfons Schäfer-Verwimp
DOI: 10.24403/jp.1338637
title: Asplenium fontanum (L.) Bernh. am Kyffhäuser - ein Neufund für Ostdeutschland / F. Böhme und L. Hegedüs
DOI: 10.24403/jp.1339225
title: Neues über das isolierte Vorkommen von Rhinanthus rumelicus Velen. (Drüsiger Klappertopf) bei Jena / Brigitte Böhme
DOI: 10.6084/m9.figshare.25151937.v1
title: Jaceosidin induces apoptosis and inhibits migration in AGS gastric cancer cells by regulating ROS-mediated signaling pathways

description: Jaceosidin (JAC) is a natural flavonoid with anti-oxidant and other pharmacological activities; however, its anti-cancer mechanism remains unclear. We investigated the mechanism of action of JAC in gastric cancer cells. Cytotoxicity and apoptosis assays showed that JAC effectively killed multiple gastric cancer cells and induced apoptosis in human gastric adenocarcinoma AGS cells via the mitochondrial pathway. Network pharmacological analysis suggested that its activity was linked to reactive oxygen species (ROS), AKT, and MAPK signaling pathways. Furthermore, JAC accumulated ROS to up-regulate p-JNK, p-p38, and IκB-α protein expressions and down-regulate the p-ERK, p-STAT3, and NF-κB protein expressions. Cell cycle assay results showed that JAC accumulated ROS to up-regulate p21 and p27 protein expressions and down-regulate p-AKT, CDK2, CDK4, CDK6, Cyclin D1, and Cyclin E protein expressions to induce G0/G1 phase arrest. Cell migration assay results showed JAC accumulated ROS to down-regulate Wnt-3a, p-GSK-3β, N-cadherin, and β-catenin protein expressions and up-regulate E-cadherin protein expression to inhibit migration. Furthermore, N-acetyl cysteine pre-treatment prevented the change of these protein expressions. In summary, JAC induced apoptosis and G0/G1 phase arrest and inhibited migration through ROS-mediated signaling pathways in AGS cells.
DOI: 10.6084/m9.figshare.25151937
title: Jaceosidin induces apoptosis and inhibits migration in AGS gastric cancer cells by regulating ROS-mediated signaling pathways

description: Jaceosidin (JAC) is a natural flavonoid with anti-oxidant and other pharmacological activities; however, its anti-cancer mechanism remains unclear. We investigated the mechanism of action of JAC in gastric cancer cells. Cytotoxicity and apoptosis assays showed that JAC effectively killed multiple gastric cancer cells and induced apoptosis in human gastric adenocarcinoma AGS cells via the mitochondrial pathway. Network pharmacological analysis suggested that its activity was linked to reactive oxygen species (ROS), AKT, and MAPK signaling pathways. Furthermore, JAC accumulated ROS to up-regulate p-JNK, p-p38, and IκB-α protein expressions and down-regulate the p-ERK, p-STAT3, and NF-κB protein expressions. Cell cycle assay results showed that JAC accumulated ROS to up-regulate p21 and p27 protein expressions and down-regulate p-AKT, CDK2, CDK4, CDK6, Cyclin D1, and Cyclin E protein expressions to induce G0/G1 phase arrest. Cell migration assay results showed JAC accumulated ROS to down-regulate Wnt-3a, p-GSK-3β, N-cadherin, and β-catenin protein expressions and up-regulate E-cadherin protein expression to inhibit migration. Furthermore, N-acetyl cysteine pre-treatment prevented the change of these protein expressions. In summary, JAC induced apoptosis and G0/G1 phase arrest and inhibited migration through ROS-mediated signaling pathways in AGS cells.
DOI: 10.24403/jp.1339229
title: New insights into the actual taxonomical status of the Thuringian Pinguicula gypsophila Wallroth (Lentibulariaceae)? / S. Jost Casper
DOI: 10.24403/jp.1339238
title: Bibliographie der Verbreitungskarten cubanischer Gefäßpflanzen / Hermann Manitz
DOI: 10.6084/m9.figshare.14715104.v2
title: Additional file 11 of Highly recurrent CBS epimutations in gastric cancer CpG island methylator phenotypes and inflammation

description: Additional file 11: Table S10. List of differentially methylated (β-value difference ≥ 0.2) conserved CpG probes in GES1 CBS-deficient clones.
DOI: 10.6084/m9.figshare.14715116
title: Additional file 15 of Highly recurrent CBS epimutations in gastric cancer CpG island methylator phenotypes and inflammation

description: Additional file 15: Table S14. List of CpG islands overlapping hypermethylated CpG sites in CBS-deficient cells and GIM-GC common CIMP signature (P &lt; 1 × 10-4, bootstrapping using 10000 samples).
DOI: 10.48370/ofd/sedl2p
title: Sorex araneus - 16163, Zoological collection of the Mammal Research Institute, PAS

description: Sorex araneus (Common shrew) from Zoological collection of the Mammal Research Institute, PAS. Collected 1955-11-27, in: Białowieża National Park, Poland. Material type:
DOI: 10.48370/ofd/ww3kwz
title: Sorex araneus - 76062, Zoological collection of the Mammal Research Institute, PAS

description: Sorex araneus (Common shrew) from Zoological collection of the Mammal Research Institute, PAS. Collected 1968-07-17, in: Białowieża National Park, Poland. Material type:
DOI: 10.48370/ofd/l1sydw
title: Sorex araneus - 73843, Zoological collection of the Mammal Research Institute, PAS

description: Sorex araneus (Common shrew) from Zoological collection of the Mammal Research Institute, PAS. Collected 1968-05-02, in: Białowieża National Park, Poland. Material type:
DOI: 10.48370/ofd/5hsbcr
title: Sorex araneus - 105049, Zoological collection of the Mammal Research Institute, PAS

description: Sorex araneus (Common shrew) from Zoological collection of the Mammal Research Institute, PAS. Collected 1972-06-11, in: Białowieża National Park, Poland. Material type:
DOI: 10.48370/ofd/gmtt6c
title: Sorex araneus - 110719, Zoological collection of the Mammal Research Institute, PAS

description: Sorex araneus (Common shrew) from Zoological collection of the Mammal Research Institute, PAS. Collected 1973-08-28, in: Białowieża National Park, Poland. Material type:
DOI: 10.48370/ofd/gichf8
title: Sorex araneus - 106850, Zoological collection of the Mammal Research Institute, PAS

description: Sorex araneus (Common shrew) from Zoological collection of the Mammal Research Institute, PAS. Collected 1972-07-27, in: Białowieża National Park, Poland. Material type:
DOI: 10.48370/ofd/buzwjz
title: Sorex araneus - 6629, Zoological collection of the Mammal Research Institute, PAS

description: Sorex araneus (Common shrew) from Zoological collection of the Mammal Research Institute, PAS. Collected 1954-09-13, in: Białowieża National Park, Poland. Material type:
DOI: 10.48370/ofd/rp32ok
title: Sorex araneus - 25609, Zoological collection of the Mammal Research Institute, PAS

description: Sorex araneus (Common shrew) from Zoological collection of the Mammal Research Institute, PAS. Collected 1961-08-16, in: Białowieża National Park, Poland. Material type:
DOI: 10.48370/ofd/xbktlb
title: Sorex araneus - 147210, Zoological collection of the Mammal Research Institute, PAS

description: Sorex araneus (Common shrew) from Zoological collection of the Mammal Research Institute, PAS. Collected 1983-07-20, in: Białowieża National Park, Poland. Material type:
DOI: 10.48370/ofd/g7eigv
title: Sorex araneus - 124122, Zoological collection of the Mammal Research Institute, PAS

description: Sorex araneus (Common shrew) from Zoological collection of the Mammal Research Institute, PAS. Collected 1977-01-26, in: Białowieża National Park, Poland. Material type:
DOI: 10.48370/ofd/wv5lbq
title: Sorex araneus - 4832, Zoological collection of the Mammal Research Institute, PAS

description: Sorex araneus (Common shrew) from Zoological collection of the Mammal Research Institute, PAS. Collected 1954-06-29, in: Białowieża National Park, Poland. Material type:
DOI: 10.48370/ofd/bs5x7v
title: Sorex araneus - 10298, Zoological collection of the Mammal Research Institute, PAS

description: Sorex araneus (Common shrew) from Zoological collection of the Mammal Research Institute, PAS. Collected 1955-07-08, in: Białowieża National Park, Poland. Material type:
DOI: 10.48370/ofd/rmd2gx
title: Sorex araneus - 7319, Zoological collection of the Mammal Research Institute, PAS

description: Sorex araneus (Common shrew) from Zoological collection of the Mammal Research Institute, PAS. Collected 1954-12-19, in: Białowieża National Park, Poland. Material type:
DOI: 10.48370/ofd/buhyfe
title: Sorex araneus - 28788, Zoological collection of the Mammal Research Institute, PAS

description: Sorex araneus (Common shrew) from Zoological collection of the Mammal Research Institute, PAS. Collected 1962-08-19, in: Białowieża National Park, Poland. Material type:
DOI: 10.48370/ofd/t0hyj3
title: Sorex araneus - 110466, Zoological collection of the Mammal Research Institute, PAS

description: Sorex araneus (Common shrew) from Zoological collection of the Mammal Research Institute, PAS. Collected 1973-07-25, in: Białowieża National Park, Poland. Material type:
DOI: 10.48370/ofd/tkrl7n
title: Sorex araneus - 44662, Zoological collection of the Mammal Research Institute, PAS

description: Sorex araneus (Common shrew) from Zoological collection of the Mammal Research Institute, PAS. Collected 1965-07-28, in: Białowieża National Park, Poland. Material type:
DOI: 10.48370/ofd/khtcso
title: Sorex araneus - 107179, Zoological collection of the Mammal Research Institute, PAS

description: Sorex araneus (Common shrew) from Zoological collection of the Mammal Research Institute, PAS. Collected 1972-08-05, in: Białowieża National Park, Poland. Material type:
DOI: 10.48370/ofd/soqccs
title: Sorex araneus - 53793, Zoological collection of the Mammal Research Institute, PAS

description: Sorex araneus (Common shrew) from Zoological collection of the Mammal Research Institute, PAS. Collected 1966-08-01, in: Białowieża National Park, Poland. Material type:
DOI: 10.48370/ofd/yokosc
title: Sorex araneus - 32924, Zoological collection of the Mammal Research Institute, PAS

description: Sorex araneus (Common shrew) from Zoological collection of the Mammal Research Institute, PAS. Collected 1963-08-24, in: Białowieża National Park, Poland. Material type:
DOI: 10.48370/ofd/aed6mf
title: Sorex araneus - 20232, Zoological collection of the Mammal Research Institute, PAS

description: Sorex araneus (Common shrew) from Zoological collection of the Mammal Research Institute, PAS. Collected 1958-08-13, in: Białowieża National Park, Poland. Material type:
DOI: 10.48370/ofd/pslrks
title: Sorex araneus - 71779, Zoological collection of the Mammal Research Institute, PAS

description: Sorex araneus (Common shrew) from Zoological collection of the Mammal Research Institute, PAS. Collected 1968-01-24, in: Białowieża National Park, Poland. Material type:
DOI: 10.48370/ofd/xc44ni
title: Sorex araneus - 44711, Zoological collection of the Mammal Research Institute, PAS

description: Sorex araneus (Common shrew) from Zoological collection of the Mammal Research Institute, PAS. Collected 1965-08-03, in: Białowieża National Park, Poland. Material type:
DOI: 10.48370/ofd/gfgdzr
title: Sorex araneus - 162753, Zoological collection of the Mammal Research Institute, PAS

description: Sorex araneus (Common shrew) from Zoological collection of the Mammal Research Institute, PAS. Collected 1993-07-12, in: Białowieża National Park, Poland. Material type:
DOI: 10.48370/ofd/khmfcq
title: Sorex araneus - 110118, Zoological collection of the Mammal Research Institute, PAS

description: Sorex araneus (Common shrew) from Zoological collection of the Mammal Research Institute, PAS. Collected 1973-07-05, in: Białowieża National Park, Poland. Material type:
DOI: 10.48370/ofd/2t185x
title: Sorex araneus - 17290, Zoological collection of the Mammal Research Institute, PAS

description: Sorex araneus (Common shrew) from Zoological collection of the Mammal Research Institute, PAS. Collected 1956-09-01, in: Białowieża National Park, Poland. Material type:
DOI: 10.48370/ofd/ddafu5
title: Sorex araneus - 32938, Zoological collection of the Mammal Research Institute, PAS

description: Sorex araneus (Common shrew) from Zoological collection of the Mammal Research Institute, PAS. Collected 1963-08-25, in: Białowieża National Park, Poland. Material type:
DOI: 10.48370/ofd/m5lwkq
title: Sorex araneus - 21036, Zoological collection of the Mammal Research Institute, PAS

description: Sorex araneus (Common shrew) from Zoological collection of the Mammal Research Institute, PAS. Collected 1959-04-20, in: Białowieża National Park, Poland. Material type:
DOI: 10.48370/ofd/iytcpj
title: Sorex araneus - 2356, Zoological collection of the Mammal Research Institute, PAS

description: Sorex araneus (Common shrew) from Zoological collection of the Mammal Research Institute, PAS. Collected 1953-07-17, in: Białowieża National Park, Poland. Material type:
DOI: 10.48370/ofd/dbo3mf
title: Sorex araneus - 13729, Zoological collection of the Mammal Research Institute, PAS

description: Sorex araneus (Common shrew) from Zoological collection of the Mammal Research Institute, PAS. Collected 1955-09-08, in: Białowieża National Park, Poland. Material type:
DOI: 10.48370/ofd/os1kpz
title: Sorex araneus - 97946, Zoological collection of the Mammal Research Institute, PAS

description: Sorex araneus (Common shrew) from Zoological collection of the Mammal Research Institute, PAS. Collected 1971-06-28, in: Białowieża National Park, Poland. Material type:
DOI: 10.48370/ofd/nck0qm
title: Sorex araneus - 18334, Zoological collection of the Mammal Research Institute, PAS

description: Sorex araneus (Common shrew) from Zoological collection of the Mammal Research Institute, PAS. Collected 1957-06-27, in: Białowieża National Park, Poland. Material type: