cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.25125272.v1
title: Supplementary Material for: Predictors and prognosis of early neurological outcomes on patients with Vertebrobasilar artery occlusion undergoing endovascular treatment

description: Background: This research explored the factors influencing early neurological outcomes (ENO) in patients who had vertebrobasilar artery occlusion (VBAO) and received endovascular treatment (EVT), as well as examining the causal influence of ENO on the prognosis of VBAO patients.
Methods: A retrospective review was carried out on patients from 65 Chinese stroke centers, all within 24 hours of the estimated occlusion time. ENO includes early neurological improvement (ENI) and early neurological deterioration (END), defined as a decrease or an increase of at least 4 points in NIHSS score between baseline and 24 hours after EVT. Death within 24 hours after EVT also consider as END. END was further divided into explainable END and unexplainable END (unEND). Independent predictors of ENO and the association between ENO and outcomes in patients with VBAO were determined using center-adjusted analyses. The study developed a multivariate logistic regression model to examine the comparative risk of unEND versus explainable END on the clinical outcomes in VBAO patients.
Results: A total of 2257 patients were included. Glasgow Coma Scale (GCS) (OR 1.16, 95% CI 1.03-1.30) and successful reperfusion (OR 1.15, 95% CI 1.02-1.30) were associated with ENI. Baseline NIHSS (OR 0.60, 95% CI 0.53-0.68), successful reperfusion (OR 0.79, 95% CI 0.71-0.89) and puncture to reperfusion time (OR 1.17, 95% CI 1.03-1.33) were associated with END. When examining three-month prognostic indexes, both END and ENI were found to be linked to the three-month outcomes, but in opposite directions. A subgroup analysis of END suggested that unexplained END typically demonstrated a more favorable prognosis compared to explained END, although the prognosis remained generally unfavorable.
Conclusions: ENO, whether they manifested as early improvement or deterioration, were linked to the prognosis of VBAO patients undergoing EVT. The outcomes after unEND were more favorable than those following explained END.
DOI: 10.6084/m9.figshare.979291.v1
title: Biome- and year-specific global soil respiration

description: Bond-Lamberty and Thomson (2010, link below) used an empirical model, based on a global soil respiration database, to predict the global flux. These data summarizes that model's outputs by year (1961-2008) and biome. Fields include: rs and rh: soil respiration and heterotrophic respiration, Pg C MAT and MAP: mean annual temperature and precipitation, area-weighted, C and mm T_anomaly and P_anomaly: deviations from 1961-1990 mean, C and mm area: biome area, km2 Summed by year, these numbers will produce the global flux shown in Figure 2 in Bond-Lamberty and Thomson (2010).
DOI: 10.6084/m9.figshare.28882601.v1
title: bam2

description: bai sra
DOI: 10.6084/m9.figshare.22002708.v1
title: Efficacy and Safety of Bevacizumab for Treating Glioblastoma: A Systematic Review and Meta-Analysis of Phase II and III Randomized Controlled Trials

description: To fully investigate the efficacy and safety of bevacizumab for glioblastoma. Databases were searched for phase II/III randomized controlled trials treated with bevacizumab. Bevacizumab significantly improved the PFS in glioblastoma patients, but did not prolong OS. PFS was significantly prolonged in both first-line and second-line treatment. Bevacizumab plus temozolomide was correlated with improved PFS for patients with different MGMT methylation status. Bevacizumab could increase the risk of hypertension, proteinuria, thromboembolic, and infection. Hypertension should be well concerned. Bevacizumab-containing regimen can significantly improve PFS, but did not prolong OS.
DOI: 10.6084/m9.figshare.7578428.v1
title: Nicastrin knockdown RT-qPCR - stable knockdown

description: These data are the real-time qPCR of HEK001 and HEK293 cell lines stably knocked down for a nicastrin specific shRNA or a luciferase-specific shRNA.<br>
DOI: 10.6084/m9.figshare.28890869.v1
title: Pentingnya Ilmu Agama Dalam Bidang Kesehatan Khusunya Dalam Profesi Keperawatan

description: Peran agama dalam keperawatan adalah topik yang jarang untuk dibahas, padahal kita tahu hal ini sangat berpengaruh di dalam pelayanan, hal ini terbukti dengan di dalam keperawatan kita juga mengenal tentang kebutuhan spiritual (walaupun tidak benar-benar dapat disamakan dengan agama),bukan tentang pemenuhan kebutuhan spiritual, tetapi yang berhubungan dengan pendidikan agama bagi keperawatan. Agama tetap penting untuk diajarkan, karena untuk menekankan aspek tertentu bagi masyarakat kita. Peran agama sangat besar, tinggal bagaimana pemanfaatannya yang perlu dibenahi. Bila mata kuliah agama hanya mengajarkan agama secara umum saja yang tidak mengena dengan kehidupan profesional, jadinya hanya formalitas mengajarkan,agama karena tidak mau disebut sebagai institusi yang tidak mengajarkan akhlak pada mahasiswa. Dalam kehidupan profesional tiap cabang ilmu keperawatan sudah mempunyai patokan tentang apa yang harus dilakukan ataupun tidak ,tentang hal yang baik dan buruk. Selain itu juga ada mata kuliah etika keperawatan yang akan membuat seorang perawat mempunyai akhlak yang baik dan terampil menjadi perawat profesional. Pendidikan akhlak di bangku kuliah bermanfaat bagi mahasiswa keperawatan agar bisa menerapkan keterampilannya pada pasien dengan agama-agama yang berbeda.
DOI: 10.6084/m9.figshare.3413605.v1
title: prediction-of-allosteric-sites-and-mediating-interactions-through-bond-to-bond-propensities-data.zip

description: The zip file contains three directories:<br>1. test-set<br>This directory contains the propensity and quantile scores for the 20 proteins in the allosteric test set. The PDB files used are included, as well as the details of the active-site ligand and the allosteric site residues.<br>2. rrin<br>This directory contains the results from our analysis of residue-residue interaction networks. Each protein has four subdirectories 6, 7, 8, 10 corresponding to the results obtained from constructing RRINs with different cut-off radii.<br>2. reference-set<br>This directory contains the results from our analysis of 100 reference proteins, which we have used to obtain reference quantiles to compare our test set against.<br>
DOI: 10.6084/m9.figshare.13139810.v2
title: Table S1 from Lupo et al. Contamination in reference sequence databases: time for divide-and-rule tactics.

description: <b>This Excel file is Table S1: Contamination levels for 111,088 bacterial genomes of NCBI RefSeq.</b> This table includes all CheckM classic output fields of contamination estimation (option lineage_wf). Estimates from Physeter in k-fold mode are further provided for 12,326 genomes for which CheckM values were not usable. The reasons for the rejection of CheckM estimates in these cases are given.<br>
DOI: 10.6084/m9.figshare.20626821.v1
title: Atresia genotypes

description: Genotypes for Holstein-Friesian case-control for intestinal atresia in plink form with phenotypes in seperate file. Genotypes for Jersey family or intestinal atresia in plink form with phenotypes included in plink file.
DOI: 10.6084/m9.figshare.19144385.v1
title: Supplementary Material for: Complementary and Alternative Therapies for Onychomycosis: A Systematic Review of the Clinical Evidence

description: <b><i>Introduction:</i></b> Onychomycosis is notoriously difficult to treat. While oral antifungals are the most efficacious treatment for onychomycosis, they are contraindicated in certain patient populations, and patients may desire lower risk and accessible alternatives to systemic agents. In this study, we examine the clinical evidence supporting the use of complementary and alternative therapies in the treatment of onychomycosis. <b><i>Methods:</i></b> PubMed, Embase, and Cochrane Library were searched for clinical trials, observational studies, and case reports/case series, examining the efficacy of a complementary or alternative therapy for the treatment of onychomycosis. <b><i>Results:</i></b> We identified 17 articles studying a complementary and alternative therapy for onychomycosis, including tea tree oil (<i>n</i> = 5), <i>Ageratina pichinchensis</i> (<i>n</i> = 3), <i>Arthrospira maxima</i> (<i>n</i> = 2), natural coniferous resin lacquer (<i>n</i> = 2), Vicks VapoRub<sup>®</sup> (<i>n</i> = 2), propolis extract (<i>n</i> = 2), and ozonized sunflower oil (<i>n</i> = 1). <b><i>Conclusion:</i></b> Given the rise of antifungal resistance, complementary and alternative therapies should continue to be studied as adjunctive or alternative therapy for onychomycosis. While preliminary evidence exists for several complementary and alternative therapies in the treatment of onychomycosis, large-scale, randomized, placebo-controlled trials are needed prior to endorsing their use to patients.
DOI: 10.6084/m9.figshare.22233862.v1
title: Supplemental Data Tables: Tectonic settings influence the geochemical and microbial diversity of Peru hot springs

description: Data tables that support: Upin, H., Newell, D. L., Coleman, D. R., and Boyd, E. S., in press, Tectonic influences on the microbial diversity of Peru hot springs: Communications Earth & Environment. <br> This repository includes the sampling and analytical methods description that support five tables. Table 1 reports field information for 14 hot springs including their location and field parameters (e.g., T, C, conductivity). Table 2 reports the major ion chemistry. Table 3 reports the trace element chemistry. Table 4 reports the dissolved gas composition of the springs. Table 5 reports the 16S rRNA results - specifcally the taxonomy for OTUs &gt;= 1% relative abundance in the planktonic and sediments component from the 14 hot springs.
DOI: 10.11583/dtu.20014070.v1
title: ITC 2019 post-competition reduced datasets

description: This is the post-competition reduced version of the International Timetabling Competition 2019 (ITC 2019) datasets. The datasets have been reduced after the competition deadline and were thus not used during the competition. The files are in the same format as the original ITC 2019 datasets, making them easy to use.
DOI: 10.6084/m9.figshare.11346890.v1
title: Supplementary Material for: Utility of Genomic Testing after Renal Biopsy

description: <b><i>Background:</i></b> Renal biopsy is the mainstay of renal pathological diagnosis. Despite sophisticated diagnostic techniques, it is not always possible to make a precise pathological diagnosis. Our aim was to identify a genetic cause of disease in patients who had undergone renal biopsy and determine if genetic testing altered diagnosis or treatment. <b><i>Methods:</i></b> Patients with suspected familial kidney disease underwent a variety of next-generation sequencing (NGS) strategies. The subset of these patients who had also undergone native kidney biopsy was identified. Histological specimens were reviewed by a consultant pathologist, and genetic and pathological diagnoses were compared. <b><i>Results:</i></b> Seventy-five patients in 47 families underwent genetic sequencing and renal biopsy. Patients were grouped into 5 diagnostic categories based on pathological diagnosis: tubulointerstitial kidney disease (TIKD; <i>n</i> = 18); glomerulonephritis (GN; <i>n</i> = 15); focal segmental glomerulosclerosis and Alport Syndrome (<i>n</i> = 11); thrombotic microangiopathy (TMA; <i>n</i> = 17); and nonspecific pathological changes (<i>n</i> = 14). Thirty-nine patients (52%) in 21 families (45%) received a genetic diagnosis; 13 cases (72%) with TIKD, 4 (27%) with GN, 6 (55%) with focal segmental glomerulosclerosis/Alport syndrome, and 10 (59%) with TMA and 6 cases (43%) with nonspecific features. Genetic testing resulted in changes in understanding of disease mechanism in 21 individuals (54%) in 12 families (57%). Treatment would have been altered in at least 26% of cases (10/39). <b><i>Conclusions:</i></b> An accurate genetic diagnosis can result in changes in clinical diagnosis, understanding of pathological mechanism, and treatment. NGS should be considered as a complementary diagnostic technique to kidney biopsy in the evaluation of patients with kidney disease.
DOI: 10.6084/m9.figshare.24192501.v1
title: A description of good kinematic and kinetic data in the post-processed files

description: The amount of strides with good kinematic and kinetic data in the post-processed MAT files are described in the .xls file “NrStrides”.
DOI: 10.6084/m9.figshare.27904980.v1
title: Exploring patterns and trends of snake roadkill in the new world: research gaps and mitigation strategies

description: This README file was generated on 2024-01-12 by Daniel Faustino Gomes# General information## Dataset TitleExploring patterns and trends of snake roadkill in the new world: research gaps and mitigation strategies## Date of Data Collection2024## Contributors*Daniel Faustino Gomes:Departamento de Vertebrados, Museu Nacional, Universidade Federal do Rio de Janeiro, Quinta da Boa Vista, São Cristóvão, 20940-040, Rio de Janeiro, Brasil.*Cecília Bueno:Universidade Veiga de Almeida, Campus Tijuca, 20271-901 Rio de Janeiro, RJ, Brasil.*Paulo Passos:Departamento de Vertebrados, Museu Nacional, Universidade Federal do Rio de Janeiro, Quinta da Boa Vista, São Cristóvão, 20940-040, Rio de Janeiro, Brasil.## OverviewThis supplemental dataset, an integral part of our research paper, contains data crucial to understanding the patterns and trends in roadkills of New World snakes discovered in our study. It includes two Excel documents - General data (data, species and landscape use) and Studies used for data collection (Authors, Title and DOI).## Data Formats* **Excel Files:*** **.xlsx/.xls**: Utilized for organizing and presenting data summaries and metadata.# Supplementary File 1.## File FormatExcel File (.xlsx)## Content OverviewThis file presents information such as:first tab - Authors, year of publication, country of publication, size of the highway, type of pavement, lanes roads, traffic volume, maximum speed, mitigation measure for section, sampling time (in months), sampling time, monitoring means, sampling speed, sampling, sampling period in datails; sampling period (morning; afternoon; evening), sampled group, total number (carcass), snakes, N species, Hotspots-hotmoments, near the conservation unit and landscape categories.second tab - list of species present in the 91 studies surveyed, in addition to conservation status (IUCN).third tab - classification of land use according to the authors.# Supplementary File 2.Excel File (.xlsx)## Content OverviewThis file presents survey of studies (N=91), description of: authors + title + DOI## Purpose and Utility* These files contain a broad survey of studies on roadkill snakes in Latin America, with the aim of understanding and filling knowledge gaps.<br><br>
DOI: 10.6084/m9.figshare.7343036.v2
title: Supplemental Material and Files for The Genetic Basis of Mutation Rate Variation in Yeast

description: Supplemental Material and Files for The Genetic Basis of Mutation Rate Variation in Yeast.<br>
DOI: 10.6084/m9.figshare.26342269.v3
title: Color and brightness at work; Shedding some light on mind wandering

description: The dataset contains EEG (demographic, raw data and processed data) from 20 participants in five conditions (Eyes open, white light 300 lux (rest 1), white light 800 lux (rest 2), blue light 300 lux (rest 3), blue light 800 lux (rest 4))
DOI: 10.6084/m9.figshare.10069055.v1
title: Supplementary Material for: Imaging of Carotid Plaque Neovascularization by Contrast-Enhanced Ultrasound and Dynamic Contrast-Enhanced Magnetic Resonance Imaging

description: <b><i>Background:</i></b> Carotid plaque neovascularization (<i>vasa vasorum</i> [VV]) may be useful for detecting high-risk atherosclerotic plaques. Contrast-enhanced ultrasound (CEUS) and dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) are 2 commonly used techniques for imaging VV of the carotid plaque, yet the relationship between their measurements remains unknown. <b><i>Objectives:</i></b> We aimed to blindly evaluate the correlation between CEUS and DCE-MRI in measuring carotid plaque VV. <b><i>Methods:</i></b> We recruited subjects with asymptomatic carotid stenosis (≥50%). VV was graded by CEUS, based on richness of contrast signal, according to 3 different methods named CEUS_A, CEUS_B and CEUS_C on different point scales (the higher the values, the higher the estimated VV). A 3.0 T MRI scanner was used for VV quantification by DCE-MRI using gadolinium contrast kinetic modelling for computing the fractional plasma volume (<i>vp</i>) and transfer constant (<i>K</i><sup><i>trans</i></sup>). <b><i>Results:</i></b> The analysis included 30 patients. A significant correlation between CEUS and DCE-MRI findings was observed when CEUS_C was used for neovessel grading and DCE-MRI was used to determine adventitial (<i>r</i> = 0.460, <i>p</i> = 0.010) and plaque (<i>r</i> = 0.374, <i>p</i> = 0.042) <i>Ktrans</i> values. CEUS_B (<i>r</i> = 0.416, <i>p</i> = 0.022) and CEUS_C (<i>r</i> = 0.443, <i>p</i> = 0.014) grading showed a significant correlation with regard to the maximal <i>K</i><sup><i>trans</i></sup>. <b><i>Conclusions:</i></b> We found a positive but weak correlation and a moderate diagnostic agreement between neovessels as visually graded by CEUS and adventitial neovessels assessed by DCE-MRI <i>K</i><sup><i>trans</i></sup> in carotid atherosclerosis. These findings may help in understanding how VV density, flow, and permeability influence in vivo measurements by CEUS and DCE-MRI as well as in selecting the most appropriate variables and imaging method in future research and potentially in clinical settings. Further confirmative studies are necessary to confirm our results.
DOI: 10.6084/m9.figshare.5128591.v1
title: Supplementary Material for: Different Phenotypes of Non-Steroidal Anti-Inflammatory Drug Hypersensitivity during Childhood

description: <b><i>Background:</i></b> Although non-steroidal anti-inflammatory drug hypersensitivity (NSAID-H) has been widely studied in adults, there is still a lack of data regarding the features and phenotypes of NSAID-H in children. Our aim was to define risk factors and different phenotypes according to clinical patterns. <b><i>Methods:</i></b> Patients with a history of reaction to any NSAIDs referred between January 2012 and October 2014 were included. After completing a European Network for Drug Allergy (ENDA) questionnaire, initial skin and/or oral provocation tests (OPTs) were performed for the offending drug. Additional OPTs were done with aspirin in case of NSAID-H to determine cross-reactivity. NSAID-hypersensitive patients were defined as being either a selective responder (SR) or cross-intolerant (CI) and further categorized according to either the ENDA/GA<sup>2</sup>LEN classification or an alternative scheme by Caimmi et al. [Int Arch Allergy Immunol 2012;159:306-312]. <b><i>Results:</i></b> Among 121 patients [58.7% male, average age 7.8 years (4.7-10.8)] with 161 NSAID-related reactions, 110 patients with 148 reactions were assessed. NSAID-H was diagnosed in 30 (27%) patients with 37 (25%) reactions. Multivariate regression analysis revealed that an immediate-type reaction and respiratory symptoms during the reaction increased the risk of a reproducible NSAID-related reaction (OR 3.508, 95% CI 1.42-8.7, p = 0.007; OR 3.951, 95% CI 1.33-11.77, p = 0.014, respectively). Additional OPTs revealed 13 SRs and 14 CIs. A family history of allergic disease was more frequent in CIs compared to SRs (57.1 vs. 15.4%, p = 0.031). Reactions belonging to CIs were more frequently characterized by angioedema compared to those of SRs (81.3 vs. 46.2%, p = 0.019). SRs and CIs were further classified as single NSAID-induced urticaria/angioedema and/or anaphylaxis (n = 13), NSAID-induced urticaria/angioedema (n = 7), NSAID-exacerbated cutaneous disease (n = 2) and NSAID-exacerbated respiratory disease (n = 1). Four CIs could not be categorized according to either classification system. One SR could not be categorized according to ENDA/GA<sup>2</sup>LEN. <b><i>Conclusion:</i></b> During childhood, NSAID-H exhibits different phenotypes and the majority of them can be categorized with current classification systems; however, classifications based on adult data may not exactly fit NSAID-H in paediatric patients.
DOI: 10.6084/m9.figshare.7064513.v1
title: ITP of chitosan

description: ITP file of chitosan using SwissParam and charges from gbasis MINI for free energy calculations in water.
DOI: 10.6084/m9.figshare.13118549.v4
title: Genomic and phenotypic analysis of COVID-19-associated pulmonary aspergillosis isolates of Aspergillus fumigatus

description: Data associated with "Genomic and phenotypic analysis of coronavirus-associated pulmonary aspergillosis isolates of Aspergillus fumigatus" by Steenwyk et al.
DOI: 10.6084/m9.figshare.26014612.v1
title: Supplementary Material for: The Study of SRSF1 Regulates Abnormal Alternative Splicing of BCL2L11 and the Role in Refractory Acute Ayeloid Leukemia

description: Introduction: Abnormalities in splicing factors, such as mutations or deregulated expression, can lead to aberrant splicing of target genes, potentially contributing to the pathogenesis of acute myeloid leukemia (AML). Despite this, the precise mechanism underlying the abnormal alternative splicing induced by SRSF1, a splicing factor associated with poor AML prognosis, remains elusive.
Methods: Using strict splicing criteria, we globally screened for alternative splicing(AS) events in NPMc-positive and NPMc-negative AML samples from TCGA. An AS network associated with AML prognosis was then established. Functional assays, including CCK-8, flow cytometry, and Western blot, were conducted on K562 and THP-1 cells overexpressing SRSF1. Cell viability following 72-hour Omipalisib treatment was also assessed. To explore the mechanism of SRSF1-induced AS, we created a BCL2L11 miniGene with a site-specific mutation at its branch point. The AS patterns of both wild-type and mutant miniGenes were analyzed following SRSF1 overexpression in HEK-293T, along with the subcellular localization of different spliceosomes.
Results: SRSF1 was significantly associated with AML prognosis. Notably, its expression was markedly upregulated in refractory AML patients compared to those with a favorable chemotherapy response. Overexpression of SRSF1 promoted THP-1 cell proliferation, suppressed apoptosis, and reduced sensitivity to Omipalisib. Mechanistically, SRSF1 recognized an aberrant branch point within the BCL2L11 intron, promoting the inclusion of a cryptic exon 3, which in turn led to apoptosis arrest.
Conclusions: Overexpression of SRSF1 and the resulting abnormal splicing of BCL2L11 are associated with drug resistance and poor prognosis in AML.