cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.17632/hrp3mwjmh8.1
title: Characteristics and outcomes of expansion cohorts in phase 1 oncology trials: a systematic review

description: Phase 1 clinical trials have evolved markedly over the last decade. The urgent need for drug development for cancer patients, together with the greater complexity of novel therapies, have led to the increasing importance of expansion cohorts (ECs) within phase 1 trial design. 
We conducted a systematic review of MEDLINE and EMBASE, focusing on oncology phase 1 trials with ECs involving adult participants published from 2019 to 2023. The objective was to assess the characteristics, purpose and outcomes of ECs. Descriptive analysis was performed, and a mixed-effects meta-regression model was conducted to analyse the response rates.
479 published phase 1 trials with ECs were analysed. The objective of the ECs was clearly stated in 55.7% of studies (76.8% safety, 16.5% dose refinement, 25.8% pharmacokinetics, 22.1% pharmacodynamics, 77.5% efficacy). 117 trials (24.4%) included a statistical justification plan. The mean Overall Response Rate (ORR) for studies recruiting solid tumour patients was 20.2% versus 46.8% for haematological trials. Antibody-drug conjugate trials showed the highest mean ORR (32.1%) and DCR (70.6%) among the classes of drugs. Combination trials, Trials which included a statistical justification for the expansion cohort, Haematology trials and Trials not containing Immunotherapy were significantly related with higher ORR. 59.1% of the reviewed studies progressed to later-stage trials registered in clinicaltrials.gov. 
ECs have evolved to become large dynamic studies which enrol more patients, focus on efficacy as well as safety, and involve novel therapies. This study highlights the importance of statistical justification and clear statement of ECs objectives to ensure meaningful early-phase trial outcomes.
DOI: 10.17632/fm4mf4rv3x
title: Supplementary material for "Impact of increased heterozygosity on Nordic Total Merit traits in dairy cattle: Potential for mating strategy optimization"

description: This dataset contains supplementary figures and tables for the manuscript entitled "Impact of increased heterozygosity on Nordic Total Merit traits in dairy cattle: Potential for mating strategy optimization" submitted to Journal of Dairy Science.
DOI: 10.17632/fm4mf4rv3x.1
title: Supplementary material for "Impact of increased heterozygosity on Nordic Total Merit traits in dairy cattle: Potential for mating strategy optimization"

description: This dataset contains supplementary figures and tables for the manuscript entitled "Impact of increased heterozygosity on Nordic Total Merit traits in dairy cattle: Potential for mating strategy optimization" submitted to Journal of Dairy Science.
DOI: 10.17632/psjyzz5sk9
title: Bases de datos para la gestión de la capacidad instalada y ausentismos en Hospital de Engativá

description: Base de datos sobre gestión de la capacidad instalada y ausentismo laboral para el proyecto de gestión en salud y enfermería.
DOI: 10.17632/psjyzz5sk9.1
title: Bases de datos para la gestión de la capacidad instalada y ausentismos en Hospital de Engativá

description: Base de datos sobre gestión de la capacidad instalada y ausentismo laboral para el proyecto de gestión en salud y enfermería.
DOI: 10.17632/34g9s345sx
title: Base de datos: educación prenatal e innovación

description: Búsqueda de base de datos sobre la educación prenatal y la innovación en el área
DOI: 10.17632/34g9s345sx.1
title: Base de datos: educación prenatal e innovación

description: Búsqueda de base de datos sobre la educación prenatal y la innovación en el área
DOI: 10.17632/7mvydssb2x
title: UAV monitoring of Harbour Porpoises at Kullaberg Nature Reserve, Sweden

description: Each row is a subarea sample on a specific day at a specific time, with corresponding data on environmental covariates, details about the area, how many porpoises were detected during review, and if porpoises were detected in the field via eye-scan.
DOI: 10.17632/7mvydssb2x.1
title: UAV monitoring of Harbour Porpoises at Kullaberg Nature Reserve, Sweden

description: Each row is a subarea sample on a specific day at a specific time, with corresponding data on environmental covariates, details about the area, how many porpoises were detected during review, and if porpoises were detected in the field via eye-scan.
DOI: 10.17632/gk7nmgv95w
title: Differentiation of promyelocytic HL-60 cell line into primed neutrophils for the evaluation of antiapoptotic effects of poorly soluble nanoparticles

description: Neutrophil apoptosis is an important determinant of intensity and duration of neutrophilic inflammation. The interaction of poorly soluble nanoparticles with primed neutrophils can reduce their natural apoptosis rates. This reaction may contribute to pathogenic consequences of increased neutrophilic inflammation. Toxicological studies aiming to identify hazards of such materials with primary neutrophils are however challenging due to the short life span of these cells and a high donor to donor variability. Our purpose was the establishment of a culturable neutrophil-like cell line as a suitable model for studies of antiapoptotic effects of poorly soluble combustion-derived environmental nanoparticles. Therefore, differentiation protocols for the promyelocytic leukemia HL-60 cell line based on commonly used differentiation inducers all-trans retinoic acid (ATRA) and dimethyl sulfoxide (DMSO) were established and compared.

The data demonstrate that only a combined cell treatment with ATRA and DMSO for a period of 5 days leads to the complete HL-60 differentiation with the typical neutrophil morphology and characteristic features of neutrophil maturation like cell cycle arrest, increase in differentiation marker CD11b, loss of proliferation marker CD71, and increased phagocytic capacity. Exposure of cells differentiated with ATRA + DMSO to carbon nanoparticles or proinflammatory cytokine granulocyte-macrophage colony-stimulating factor (GM-CSF) revealed a delay of apoptosis causally linked to intracellular reactive oxygen species (ROS). These data verified our earlier findings with human peripheral primed neutrophils from donors with slightly elevated proinflammatory blood plasma factors. Moreover, completely differentiated HL-60 cells possessed similar levels of L-selectin CD62L as neutrophils with primed immunophenotype, thus representing the biology of primed inflammatory neutrophils. 

Neutrophil-like HL-60 cells differentiated according to our protocol could be an appropriate substitute cell line model for studies on the effects of inhalable nanomaterials on primed inflammatory neutrophils like lung neutrophils. For such toxicological studies our cell model is preferable to peripheral neutrophils as blood neutrophils not always occur in a primed state and primed lung neutrophils from donors are not available for this purpose.
DOI: 10.17632/gk7nmgv95w.1
title: Differentiation of promyelocytic HL-60 cell line into primed neutrophils for the evaluation of antiapoptotic effects of poorly soluble nanoparticles

description: Neutrophil apoptosis is an important determinant of intensity and duration of neutrophilic inflammation. The interaction of poorly soluble nanoparticles with primed neutrophils can reduce their natural apoptosis rates. This reaction may contribute to pathogenic consequences of increased neutrophilic inflammation. Toxicological studies aiming to identify hazards of such materials with primary neutrophils are however challenging due to the short life span of these cells and a high donor to donor variability. Our purpose was the establishment of a culturable neutrophil-like cell line as a suitable model for studies of antiapoptotic effects of poorly soluble combustion-derived environmental nanoparticles. Therefore, differentiation protocols for the promyelocytic leukemia HL-60 cell line based on commonly used differentiation inducers all-trans retinoic acid (ATRA) and dimethyl sulfoxide (DMSO) were established and compared.

The data demonstrate that only a combined cell treatment with ATRA and DMSO for a period of 5 days leads to the complete HL-60 differentiation with the typical neutrophil morphology and characteristic features of neutrophil maturation like cell cycle arrest, increase in differentiation marker CD11b, loss of proliferation marker CD71, and increased phagocytic capacity. Exposure of cells differentiated with ATRA + DMSO to carbon nanoparticles or proinflammatory cytokine granulocyte-macrophage colony-stimulating factor (GM-CSF) revealed a delay of apoptosis causally linked to intracellular reactive oxygen species (ROS). These data verified our earlier findings with human peripheral primed neutrophils from donors with slightly elevated proinflammatory blood plasma factors. Moreover, completely differentiated HL-60 cells possessed similar levels of L-selectin CD62L as neutrophils with primed immunophenotype, thus representing the biology of primed inflammatory neutrophils. 

Neutrophil-like HL-60 cells differentiated according to our protocol could be an appropriate substitute cell line model for studies on the effects of inhalable nanomaterials on primed inflammatory neutrophils like lung neutrophils. For such toxicological studies our cell model is preferable to peripheral neutrophils as blood neutrophils not always occur in a primed state and primed lung neutrophils from donors are not available for this purpose.
DOI: 10.17632/ysykndmph6
title: Dataset: Microbubble Oscillations Induced by Focused Ultrasound: Key Parameters Influencing Cavitation Dose

description: Abstract from the article: 
In therapeutic ultrasound, intravenously administered microbubbles (MBs) — gas-filled agents encapsulated by lipid or protein shells — play an increasingly significant role. Originally used as ultrasound contrast agents (UCA), MBs can e.g. transiently increase BBB permeability. Under focused ultrasound, they undergo oscillations, exerting mechanical forces that temporarily disrupt tight junctions between endothelial cells, enabling localized delivery of macromolecules (e.g., &gt;400 Da), which has therapeutic potential for CNS disorders such as Alzheimer’s disease and glioblastoma. This study investigated how acoustic parameters and MB (SonoVue, Bracco) properties influence their acoustic response. Four experimental protocols assessed the effects of MB concentration (0.0008%, 0.004%, 0.016%, 0.08%, 0.4% v/v), peak negative pressure (61.5 ± 8 to 2600 ± 340 kPa), sonication time, and pulse duration (95, 190, 952 µs). Reproducibility was also evaluated. Experiments were conducted in a flow system with a focused ultrasound transducer (H101, Sonic Concepts, f 0 = 1.05 MHz) and a passive receiver. Cavitation activity was quantified using three metrics: SCD har (harmonic emissions), SCD ultra (ultraharmonic emissions), and ICD (broadband inertial cavitation). SCD har and ICD showed monotonic trends within 61.5–1300 kPa and 0.0008–0.08% MB concentration. SCD ultra was most evident at 600 and 1300 kPa for 0.016% MBs. Cavitation doses were reproducible, with 10% variability in SCD har and ICD. The number of acoustic pulses had a greater impact on cavitation dose than total effective sonication time. These findings contribute to better understanding of MB behavior in ultrasound field and may support optimization of safe and effective therapeutic protocols.
DOI: 10.17632/ysykndmph6.1
title: Dataset: Microbubble Oscillations Induced by Focused Ultrasound: Key Parameters Influencing Cavitation Dose

description: Abstract from the article: 
In therapeutic ultrasound, intravenously administered microbubbles (MBs) — gas-filled agents encapsulated by lipid or protein shells — play an increasingly significant role. Originally used as ultrasound contrast agents (UCA), MBs can e.g. transiently increase BBB permeability. Under focused ultrasound, they undergo oscillations, exerting mechanical forces that temporarily disrupt tight junctions between endothelial cells, enabling localized delivery of macromolecules (e.g., &gt;400 Da), which has therapeutic potential for CNS disorders such as Alzheimer’s disease and glioblastoma. This study investigated how acoustic parameters and MB (SonoVue, Bracco) properties influence their acoustic response. Four experimental protocols assessed the effects of MB concentration (0.0008%, 0.004%, 0.016%, 0.08%, 0.4% v/v), peak negative pressure (61.5 ± 8 to 2600 ± 340 kPa), sonication time, and pulse duration (95, 190, 952 µs). Reproducibility was also evaluated. Experiments were conducted in a flow system with a focused ultrasound transducer (H101, Sonic Concepts, f 0 = 1.05 MHz) and a passive receiver. Cavitation activity was quantified using three metrics: SCD har (harmonic emissions), SCD ultra (ultraharmonic emissions), and ICD (broadband inertial cavitation). SCD har and ICD showed monotonic trends within 61.5–1300 kPa and 0.0008–0.08% MB concentration. SCD ultra was most evident at 600 and 1300 kPa for 0.016% MBs. Cavitation doses were reproducible, with 10% variability in SCD har and ICD. The number of acoustic pulses had a greater impact on cavitation dose than total effective sonication time. These findings contribute to better understanding of MB behavior in ultrasound field and may support optimization of safe and effective therapeutic protocols.
DOI: 10.17632/bd8kbwrmtw
title: Effect of thermoelectric subcooling on COP and energy consumption of a propane heat pump

description: The building sector has an important impact on the environment, being responsible for 30 % of the total greenhouse gas emissions. Knowing that the energy consumption devoted to HVAC systems accounts for 50 % of the total energy consumption of buildings, it is paramount to develop environmentally friendly technologies able to provide green space heating to the building sector. To that purpose, this manuscript presents a computational study on propane vapor compression heat pumps which include thermoelectric subcooling to boost their operation. The combination of these technologies has been proven in the past to be very beneficial for refrigeration systems and this study concludes for the first time that propane heat pumps can highly benefit from thermoelectric subcooling. The widely conducted research includes the following parameters: ambient temperatures from −20 to 15 °C, voltage supplies to the thermoelectric modules from 0.5 to 10 VDC, number of thermoelectric subcooling blocks from 1 to 8 and two water inlet temperatures, 40 and 55 °C to study their influence on heating capacity, compressor and thermoelectric power consumptions, subcooling degree, propane mass flow, compressor capacity, COP, energy consumption and SCOP of the combined heat pump. The obtained results are very conclusive, COP enhancements up to 12.29 % are achieved when a thermoelectric subcooler with 16 modules is included in a propane heat pump already provided with an internal heat exchanger for an ambient temperature of −20 °C and a water inlet temperature of 55 °C. Additionally, improvements in Seasonal COP up to 9.98 % are achieved if the above-mentioned technologies integration between a vapor compression heat pump and a thermoelectric subcooler substitutes a conventional propane heat pump with an internal heat exchanger for space heating a single-story two-family house.
DOI: 10.17632/bd8kbwrmtw.1
title: Effect of thermoelectric subcooling on COP and energy consumption of a propane heat pump

description: The building sector has an important impact on the environment, being responsible for 30 % of the total greenhouse gas emissions. Knowing that the energy consumption devoted to HVAC systems accounts for 50 % of the total energy consumption of buildings, it is paramount to develop environmentally friendly technologies able to provide green space heating to the building sector. To that purpose, this manuscript presents a computational study on propane vapor compression heat pumps which include thermoelectric subcooling to boost their operation. The combination of these technologies has been proven in the past to be very beneficial for refrigeration systems and this study concludes for the first time that propane heat pumps can highly benefit from thermoelectric subcooling. The widely conducted research includes the following parameters: ambient temperatures from −20 to 15 °C, voltage supplies to the thermoelectric modules from 0.5 to 10 VDC, number of thermoelectric subcooling blocks from 1 to 8 and two water inlet temperatures, 40 and 55 °C to study their influence on heating capacity, compressor and thermoelectric power consumptions, subcooling degree, propane mass flow, compressor capacity, COP, energy consumption and SCOP of the combined heat pump. The obtained results are very conclusive, COP enhancements up to 12.29 % are achieved when a thermoelectric subcooler with 16 modules is included in a propane heat pump already provided with an internal heat exchanger for an ambient temperature of −20 °C and a water inlet temperature of 55 °C. Additionally, improvements in Seasonal COP up to 9.98 % are achieved if the above-mentioned technologies integration between a vapor compression heat pump and a thermoelectric subcooler substitutes a conventional propane heat pump with an internal heat exchanger for space heating a single-story two-family house.
DOI: 10.5281/zenodo.15630825
title: Minecraft Education Components Lists

description: This Excel file systematically compiles and organizes the game components identified in Minecraft Education, structured according to the conceptual framework proposed by Järvinen (2008) on his work Games without Frontiers. This record facilitates the detailed analysis and categorization of the interactive objects within the Minecraft Education virtual environment, distributed in three major categories: items, blocks and entities.
DOI: 10.5281/zenodo.15630826
title: Minecraft Education Components Lists

description: This Excel file systematically compiles and organizes the game components identified in Minecraft Education, structured according to the conceptual framework proposed by Järvinen (2008) on his work Games without Frontiers. This record facilitates the detailed analysis and categorization of the interactive objects within the Minecraft Education virtual environment, distributed in three major categories: items, blocks and entities.
DOI: 10.17632/nbssd3vmgc
title: data

description: Title: Judicial Improvement, Non-state-owned Enterprise and Enterprise Risk-taking —Evidence from the Establishment of Circuit Courts
DOI: 10.17632/nbssd3vmgc.1
title: data

description: Title: Judicial Improvement, Non-state-owned Enterprise and Enterprise Risk-taking —Evidence from the Establishment of Circuit Courts
DOI: 10.17632/7vh2g9fdxh
title: Exceptional methylmercury bioaccumulation in rice (Oryza sativa L.) from high geological background regions: Dominant role of root uptake from soil ( Original data)
DOI: 10.17632/7vh2g9fdxh.1
title: Exceptional methylmercury bioaccumulation in rice (Oryza sativa L.) from high geological background regions: Dominant role of root uptake from soil ( Original data)
DOI: 10.17632/j8kc88py35
title: Grain size of sediments in five rivers on the Eurasian continent

description: All five sampling sites exhibit river erosion. Sampling site 1 is located upstream of the Vylyui River, an important tributary of the Lena River, and is situated in the Siberian permafrost zone. The terrain is predominantly flat plains and lowlands, surrounded by coniferous forests and marshes. The annual temperature difference can exceed 80°C, making it one of the regions with the largest annual temperature differences globally. Sampling site 2 is located near the Lena River basin, which has numerous tributaries. The surface is covered by permafrost, with terrain primarily consisting of plains and lowlands, and局部 areas featuring hills and coniferous forests. This region experiences extremely cold and prolonged winters, short and warm summers, and a significant annual temperature difference. Sampling site 3 is the largest tributary of the Songhua River, with diverse terrain within the basin and a typical temperate monsoon climate, characterized by cold, dry winters and warm, humid summers. The basin contains numerous wetlands and lakes, which play an important role in regulating the climate and maintaining ecological balance. Sampling site 4 is located in a basin with a warm temperate monsoon climate, with an annual average temperature of approximately 14.9°C, dominated by southwest winds, featuring a mild climate and humid air. The Kangwang River basin has a relatively flat terrain and is part of the Huanghuai Plain. Sampling site 5 is located near the Yellow River estuary, which is the core area of the Yellow River Delta. The elevation is mostly below 10 meters, with the surface dominated by wetlands, tidal flats, and saline-alkali land. The region has a warm temperate semi-humid continental monsoon climate, with strong winds in spring, high humidity in summer, and dry air in winter.
DOI: 10.17632/j8kc88py35.1
title: Grain size of sediments in five rivers on the Eurasian continent

description: All five sampling sites exhibit river erosion. Sampling site 1 is located upstream of the Vylyui River, an important tributary of the Lena River, and is situated in the Siberian permafrost zone. The terrain is predominantly flat plains and lowlands, surrounded by coniferous forests and marshes. The annual temperature difference can exceed 80°C, making it one of the regions with the largest annual temperature differences globally. Sampling site 2 is located near the Lena River basin, which has numerous tributaries. The surface is covered by permafrost, with terrain primarily consisting of plains and lowlands, and局部 areas featuring hills and coniferous forests. This region experiences extremely cold and prolonged winters, short and warm summers, and a significant annual temperature difference. Sampling site 3 is the largest tributary of the Songhua River, with diverse terrain within the basin and a typical temperate monsoon climate, characterized by cold, dry winters and warm, humid summers. The basin contains numerous wetlands and lakes, which play an important role in regulating the climate and maintaining ecological balance. Sampling site 4 is located in a basin with a warm temperate monsoon climate, with an annual average temperature of approximately 14.9°C, dominated by southwest winds, featuring a mild climate and humid air. The Kangwang River basin has a relatively flat terrain and is part of the Huanghuai Plain. Sampling site 5 is located near the Yellow River estuary, which is the core area of the Yellow River Delta. The elevation is mostly below 10 meters, with the surface dominated by wetlands, tidal flats, and saline-alkali land. The region has a warm temperate semi-humid continental monsoon climate, with strong winds in spring, high humidity in summer, and dry air in winter.
DOI: 10.17632/bwgwyzgcb7
title: Electroreception in treehoppers: how extreme morphologies can increase electrical sensitivity - data

description: This data set contains behavioural scores for treehoppers responding to electrostatic fields, electrostatic charge measurements of 11 species of treehopper, 2 species of wasp, and 2 species of stingless bee, and laser Doppler vibrometry responses of treehopper setae to electric fields. Information on the methodology and interpretations of this data can be found in the associated publication England et al. (2025) - "Electroreception in treehoppers: how extreme morphologies can increase electrical sensitivity".