cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.23723844
title: Supplementary Material for: The Characteristics and Treatment Outcomes of 71 Duodenal Brunner’s gland Adenomas with Endoscopic Submucosal Dissection

description: Abstract Background: The aim of this study was to investigate outcomes of patients with duodenal Brunner’s gland adenomas (BGAs) that were treated endoscopically. Methods: We identified consecutive 71 patients treated at our center with endoscopic submucosal dissection (ESD) for their duodenal tumors diagnosed pathologically as BGAs over the period between January 1, 2011 and December 31, 2021. We retrospectively analyzed our experience and short- and long-term outcomes of ESD therapy on patients with BGAs. Results: Among 71 BGA patients with an average age of 57 ± 11.7 years (range: 30-82), 48 (67.6%) were male and 23 (32.4%) were female. The accuracy of preoperative diagnosis with endoscopic ultrasonography was 44.0% (22/50). The H. pylori infection was found in 29 patients (29/71, 40.8%). The median size of BGAs was 1.5 cm [interquartile range (IQR) 0.8-2.7cm]. The most common location was the duodenum bulb (50/71, 64.8%). For the ESD procedure, the median operation time was 15.0 minutes (IQR 9.5-25.5 minutes). The en-bloc and the complete resection rates were 97.2% and 92.3%, respectively. ESD-related mild acute obstructive pancreatitis was present in two patients (2/4, 50%) with BGAs located in the ampulla region. During the follow-up period, one patient with a positive peripheral margin experienced tumor recurrence 2 years after the initial ESD. There was no disease-related death for the cohort. Conclusion: ESD was an effective and safe therapeutic option for BGA patients with excellent outcomes. Long-term follow-up is needed.
DOI: 10.6084/m9.figshare.23790537
title: Supplementary Material for: Complementary medicine in acute care hospitals - questionnaire survey with heads of Bavarian hospitals

description: Introduction: The demand for complementary medicine (CM) is well studied for the outpatient sector but representative data on type and extent of inpatient care using CM are missing. Therefore, our aim was to examine the range of CM treatments offered and the type of indications for using CM in acute care hospitals in the German state of Bavaria. Methods: We conducted a cross-sectional questionnaire survey contacting the medical heads of all 388 Bavarian acute care hospitals between November 2020 and April 2021. The questionnaire included a wide range of CM to assessed availability of CM supply, most frequent indications and medical specialities. Furthermore, we assessed basic information about the hospital and the participating medical staff. Results: A total of 101 (26%) hospitals participated in the survey. At least one CM treatment was offered by 92% of the responding hospitals and 75% offered at least 5 therapy modalities (mean 10 treatments, range: 0-25). These were most commonly massage therapies (68%), relaxation techniques (63%), phytotherapy (60%), mindfulness-based treatments (53%), art, diet and exercise therapies (each 48%), aromatherapy (46%), acupuncture and compresses/poultices (both 42%). The most reported medical conditions for CM treatments (in descending order) were chronic pain, mental disorders, degenerative affections, sleep disorders, fatigue syndrome, functional gastrointestinal disorders and acute pain. Conclusion: According to the Bavarian acute care hospitals that participated in our postal survey a considerable part offered CM. Further research should include personal interviews and more detailed assessments of indications and attitudes for the use of CM in acute care hospital settings.
DOI: 10.6084/m9.figshare.24007485
title: Supplementary Material for: Survival and Swallowing Function after Primary Radiotherapy versus Transoral Robotic Surgery for Human Papillomavirus-associated Oropharyngeal Squamous Cell Carcinoma

description: Introduction: To investigate the impact of primary transoral robotic surgery (TORS) versus radiotherapy (RT) on progression-free survival (PFS), overall survival (OS), and 1-year swallowing function for patients with early-stage HPV-associated orophagyneal squamous cell carcinoma (OPSCC). Methods: Patients with stage I-II (AJCC 8th Edition) HPV-associated OPSCC treated with TORS followed by risk-adapated adjuvant therapy or (chemo)radiotherapy between 2014-2019 were identified. PFS, OS, and swallowing outcomes including gastrostomy tube (GT) use/dependence, and Functional Oral Intake Scale (FOIS) change over 1 year were compared. Results: 167 patients were analyzed: 116 treated with TORS with or without adjuvant RT, 51 treated with RT (50 chemoRT). The RT group had more advanced tumor/nodal stage, higher comorbidity, and higher rates of concurrent chemotherapy. There were no differences in 3-year PFS (88% TORS v. 75% RT) or OS (90% v. 81%) between groups, which persisted after adjusting for stage, age and comorbidity. GT use/dependence rates were higher in the RT group. Mean (SD) FOIS scores in the TORS group were 6.9 (0.4) at baseline and 6.4 (1.0) at 1-year, compared with 6.7 (0.6) and 5.6 (1.7) for the RT group. Only clinical nodal stage was found to be significantly associated with FOIS change from baseline to 1-year. Discussion/Conclusion: There were no differences in PFS or OS between patients treated with primary TORS or RT for early-stage HPV-associated OPSCC. Clinical N2 status is associated with FOIS change at 1-year and may be the major factor affecting long-term swallowing function, irrespective of primary treatment modality.
DOI: 10.6084/m9.figshare.24297085
title: Supplementary Material for: Comprehensive analysis of the relationship between cuproptosis-related gene GCSH and prognosis, tumor microenvironment infiltration, and therapy response in endometrial cancer

description: Background: Cuproptosis, a novel form of cell death regulated by protein lipoylation and implicated in mitochondrial metabolism. However, the impact of the cuproptosis-related gene γ-glutamylcysteine synthetase (GCSH) on endometrial cancer (EC) prognosis, tumor immune microenvironment, and therapeutic response remains to be further researched. Methods: The differential expression of GCSH between endometrial cancer and normal tissues was analyzed using multiple public databases. Additionally, cancer and adjacent tissues were prospectively collected from 17 EC patients, and immunohistochemical analysis was performed to further investigate GCSH expression differences. The relationship between GCSH and the prognosis and clinicopathological characteristics of EC patients was evaluated, and a nomogram was constructed to predict patient survival based on GCSH expression. Then, Gene set variation analysis (GSVA) was utilized to explore the potential biological functions of GCSH in EC. The impact of GCSH on the tumor microenvironment (TME) was estimated. Finally, the effect of GCSH on the response to immunotherapy and chemotherapeutic drugs in EC was investigated. Results: The expression of GCSH was significantly upregulated in EC. High GCSH expression was associated with poor prognosis in EC patients. Enrichment analysis showed that high GCSH was associated with immune suppression. Furthermore, high GCSH was found to be associated with a non-inflamed TME, leading to decreased infiltration levels of immune cells. Finally, it was observed that patients with high GCSH were insensitive to both immunotherapy and chemotherapeutic drugs. Conclusion: This study revealed the role of GCSH in TME, response to therapy, and clinical prognosis in EC, which provided novel insights for the therapeutic application in EC.
DOI: 10.6084/m9.figshare.24297796
title: Supplementary Material for: Mild renal function impairment and long-term outcomes in patients with three-vessel coronary artery disease: a cohort study

description: Background: Limited data are available on the long-term impact of mild renal dysfunction (eGFR 60-89 ml/min/1.73m2) in patients with three-vessel coronary disease (3VD). Methods: A total of 5,272 patients with 3VD undergoing revascularization were included and were categorized into 3 groups: normal renal function (eGFR ≥90 ml/min/1.73m2, n=2352), mild renal dysfunction (eGFR 60-89, n=2501) and moderate renal dysfunction (eGFR 30-59, n=419). Primary endpoint was all-cause death. Secondary endpoints included cardiac death and major adverse cardiac and cerebrovascular events (MACCE), a composite of death, myocardial infarction and stroke. Results During the median 7.6-year follow-up period, 555 (10.5%) deaths occurred. After multivariable adjustment, patients with mild and moderate renal dysfunction had significantly higher risks of all-cause death (adjusted HR: 1.36, 95% CI 1.07-1.70; adjusted HR 2.06, 95% CI 1.53-2.78, respectively) compared with patients with normal renal function. patients after coronary artery bypass grafting (CABG) had a lower rate of all-cause death and MACCE than those undergoing percutaneous coronary intervention (PCI) in the normal and mild renal dysfunction group, but not in the moderate renal dysfunction group. Results were similar after propensity score matching. Conclusions In patients with 3VD, even mild renal impairment was significantly associated with a higher risk of all-cause death. The superiority of CABG over PCI diminished in those with moderate renal dysfunction. Our study alerts clinicians to the early screening of mild renal impairment in patients with 3VD and provides real-world evidence on the optimal revascularization strategy in patients with renal impairment.
DOI: 10.6084/m9.figshare.24619044
title: Supplementary Material for: The Memory Alteration Test is correlated with clinical, cerebrospinal fluid, and brain imaging markers of Alzheimer disease in Lima, Peru

description: Introduction. As disease modifying therapies become available, early detection of Alzheimer’s disease (AD) becomes increasingly important. However, biomarkers in LMICs are rare and costly. Thus, we evaluated an AD-focused BCT, the Memory Alteration Test (M@T), to detect biomarker-proven AD and quantify its correlation with neurodegeneration and CSF AD biomarkers in a cohort of participants from Lima, Peru. Methods. This is a secondary analysis of a cohort of 185 participants: 63 controls, 53 with amnestic MCI (aMCI), and 69 with dementia due to AD. Participants underwent testing with M@T and a gold standard neuropsychological battery. We measured T-tau, p-tau and β-amyloid in CSF, and evaluated neurodegeneration via medial temporal atrophy score in MRI. We used Receiver-Operator Curves to determine the discriminative capacity of the total M@T score and its subdomains. We used the Pearson coefficient to correlate M@T score and CSF biomarkers. Results. The M@T had an AUC of 0.994 to discriminate between controls and cognitively impaired (aMCI or AD) patients, and an AUC of 0.98 to differentiate between aMCI and AD patients. Free-recall and cued recall had the highest AUCs of all subdomains. Total score was strongly correlated with t-tau (-0.77) and p-tau (-0.72), and moderately correlated with β-amyloid (0.66). The AUC for discrimination of neurodegeneration was 0.87. Discussion/Conclusion. The M@T had excellent discrimination of aMCI and dementia due to AD. It was strongly correlated with CSF biomarkers and had good discrimination of neurodegeneration. In LMICs, it may represent a cost-effective screening tool for aMCI and dementia caused by AD.
DOI: 10.6084/m9.figshare.22139861
title: Supplementary Material for: Predicting Complexity in Transurethral Resection of Bladder Tumours: External Validation and Modification of the Bladder Complexity Score

description: <b><i>Introduction:</i></b> First external validation of the Bladder Complexity Score (BCS) for predicting complex transurethral resection of bladder tumours (TURBT). <b><i>Methods:</i></b> For BCS calculation, TURBTs performed at our institution between January 2018 and December 2019 were reviewed for the presence of preoperative characteristics listed in the Bladder Complexity Checklist (BCC). Receiver operating characteristics (ROC) analysis was used for BCS validation. To establish a modified BCS (mBCS) with maximum area under the curve (AUC), multivariable logistic regression (MLR) analysis was performed with all BCC-characteristics for different definitions of complex TURBT. <b><i>Results:</i></b> 723 TURBTs were included in statistical analyses. Cohort’s mean BCS was 11.2 ± 2.4 points (range: 5.5–22 points). In ROC analysis, BCS could not predict complex TURBT (AUC 0.573 [95% CI: 0.517–0.628]). MLR identified tumour size (OR 2.662, <i>p</i> &lt; 0.001), and tumour number &gt; 10 (OR 6.390, <i>p</i> = 0.032) as sole predictors for the modified endpoint of complex TURBT defined as a procedure meeting &gt; 1 criterion: incomplete resection, surgery &gt; 1 h, intraoperative complication, postoperative complications Clavien-Dindo ≥ III. mBCS increased the prediction to an AUC of 0.770 (95% CI: 0.667–0.874). <b><i>Conclusion:</i></b> In this first external validation, BCS remained an insufficient predictor of complex TURBT. mBCS requires reduced parameters, is more predictive and easier to apply in clinical practice.
DOI: 10.5281/zenodo.3689582
title: New Sensitivity Curves for Gravitational-Wave Experiments

description: Supplemental material for the paper of the same name, arXiv:2002.04615 [hep-ph], consisting of all (1) strain noise power spectra, (2) power-law-integrated sensitivities, and (3) peak-integrated sensitivities presented in this paper.
DOI: 10.5281/zenodo.7867328
title: Data supporting "Modeling and evaluating the effects of irrigation on land-atmosphere interaction in southwestern Europe with the regional climate model REMO2020-iMOVE using a newly developed parameterization"

description: This data supports the analysis of the manuscript Asmus et al. 2023 "Modeling and evaluating the effects of irrigation on land-atmosphere interaction in southwestern Europe with the regional climate model REMO2020-iMOVE using a newly developed parameterization".
Simulation data
The simulation data is created with REMO2020-iMOVE using the new irrigation parameterization. The results are saved as NetCDF files with monthly mean values and/or time series (hourly) of single variables for the analysis period. A list of the simulations can be found below.
Observation data 
The observation data is published with the kind permission of ISPRA which hosts the SCIA database (www.scia.isprambiente.it). If you use this data, please make sure to include the following data source:SCIA by ISPRA - Area Climatologia operativa - Via V. Brancati 48 00144 Roma. We downloaded monthly mean values for the variables T2Max, T2Min and T2Mean from http://193.206.192.214/servertsutm/serietemporali100.php (last accessed on 14/10/2022) to verify the model results with and without irrigation parameterization. 
By untarring the tarballs, the data structure is created that is necessary to execute the analysis scripts.
For more information or additional data please contact the author.
 
tarball                       | exp_number | description 
067015.tar.gz            |  067015         | not irrigated
067016.tar.gz            | 067016          | irrigated with "adaptive water application scheme"
067017.tar.gz            | 067017          | irrigated with "adaptive water application scheme"
067019.tar.gz            | 067019          | irrigated with "flexible time water application scheme"
067020.tar.gz            | 067020          | irrigated with "prescribed water application scheme"
observation_scia.tar  | -                    | observation data from SCIA 
 
Data structure for simulation data
\<exp_number>   \monthly   \hourly      \var_series         \<variable>Note:\067015 includes static variables   \irrifrac (irrigated fraction)   \bla (land-sea-mask)
DOI: 10.5281/zenodo.7897840
title: Finding Stellar Streams in the Milky Way with CWoLa

description: These datasets are designed to accompany the paper <em>Weakly-Supervised Anomaly Detection in the Milky Way </em>by M. Pettee, S. Thanvantri, B. Nachman, D. Shih, M. R. Buckley, and J. H. Collins (https://arxiv.org/abs/2305.03761). They illustrate how the Classification Without Labels (CWoLa) technique can be applied in the search for localized anomalies -- in this case, cold stellar streams -- in the <em>Gaia </em>DR2 dataset. We consider both simulated stellar streams and the known stream GD-1. The codebase is located at https://github.com/hep-lbdl/GaiaCWoLa. These datasets are all formatted as Pandas DataFrames, and can be loaded using `df = pd.read_hdf(file)`. Datasets ending in `*_cwola.h5*` indicate that CWoLa has been applied to the stars in that dataset. For this analysis, we consider circular "patches" of the sky of radius 15° from the Gaia DR2 dataset. Columns include: μ_δ: Proper motion (declination) μ_α: Proper motion (right ascension) δ: Declination α: Right ascension α_wrapped: Right ascension, wrapped such that all angles are &gt; 0 b-r: Color g: Magnitude ϕ: Rotated & centered right ascension λ: Rotated & centered declination μ_ϕcosλ: Rotated & centered proper motion (right ascension) μ_λ: Rotated & centered proper motion (declination) stream: Boolean label (True if part of ground truth labeling for GD-1) patch_id: Index of the 21 patches of the GD-1 scan nn_score: CWoLa classifier score (0 = more background-like; 1 = more signal=like) 5d_distance: For the potential GD-1 member candidates, the 5D Euclidean distance to the nearest labeled star Files include: gd1_1_patch.h5 Example patch of GD-1 gd1_21_patches_cwola.h5 Results from applying CWoLa to the 21 patches spanning GD-1 promising_stars.h5 A list of stars identified by CWoLa that do not belong to the labeled GD-1 stream catalogue, but are close in 5D Euclidean space to labeled stars. Ordered in descending order by CWoLa classifier score. scan_bump_cwola.h5 An example of how to apply CWoLa in a scan where the stream location is unknown scan_no_bump_cwola.h5 An example of how to apply CWoLa in a scan where the stream location is unknown simulated_100_patches.h5 Results from applying CWoLa to 100 simulated streams simulated_patch.h5 A full simulated stream simulated_patch_cwola.h5 Results from applying CWoLa to the example simulated stream To recreate the full scan across GD-1, one would need to use the original 21 patches of Gaia DR2 located at 10.5281/zenodo.7897935 that were constructed for arXiv:2104.12789 [astro-ph.GA). GD-1 labels were derived from 10.5281/zenodo.1295543.
DOI: 10.6084/m9.figshare.24421252
title: Supplementary Material for: Pilotstudie zur Validierung eines prozessorientierten Fragebogens zur Erfassung körperdysmorpher Kognitionen (FKDK)

description: <b><i>Hintergrund:</i></b> Dysfunktionale Kognitionen über das eigene Aussehen sind ein Kernsymptom der körperdysmorphen Störung und Fokus in kognitiv-behavioralen Behandlungsmanualen. Jedoch ist die Rolle körperdysmorpher Kognitionen als Mediator für den Behandlungserfolg noch nicht umfassend erforscht und es existiert im deutschsprachigen Raum kein Messinstrument zur Erfassung. Ziel der Pilotstudie war die Entwicklung und vorläufige Validierung eines Fragebogens zur Erfassung körperdysmorpher Kognitionen (FKDK) sowie die Untersuchung von Veränderungen über den Therapieverlauf. <b><i>Material und Methoden:</i></b> Der FKDK misst die Auftretenshäufigkeit und Überzeugtheit spezifischer Kognitionen. An einer klinischen Stichprobe (<i>N</i> = 30) wurden Konstruktvalidität, Reliabilität und Veränderungssensitivität untersucht. Zudem wurde der Verlauf im Rahmen einer <b>prozessbasierten</b> kognitiven Therapie untersucht und evaluiert, ob der KDS-Schweregrad vor Behandlungsbeginn sowie die therapeutische Beziehung die Reduktion körperdysmorpher Kognitionen beeinflussen. <b><i>Ergebnisse:</i></b> Wir fanden eine gute interne Konsistenz sowie eine gute Veränderungssensitivität. Konvergente Korrelationen deuten ausreichende Zusammenhänge mit anderen Maßen für KDS-Schweregrad an, wobei höhere Korrelationen mit Depressionsmaßen Unklarheiten bei der Konstruktvalidität aufwerfen. Personen mit höherem KDS-Schweregrad sowie einer besseren therapeutischen Beziehung zeigten eine stärkere Reduktion der Kognitionen. <b><i>Diskussion und Schlussfolgerung:</i></b> Die faktorielle Struktur des FKDK ist ungeklärt und muss an einer größeren Stichprobe untersucht werden. Insgesamt konnte diese Studie erste Hinweise liefern, dass der FKDK aufgrund der ökonomischen Durchführung und Veränderungssensitivität zur kontinuierlichen Beobachtung im Therapieverlauf nützlich sein könnte. Zukünftige Studien sollten die Rolle körperdysmorpher Kognitionen als Mediator für den Therapieerfolg kognitiver Therapie bei KDS untersuchen.
DOI: 10.18739/a21v5bf8t
title: River ice and open water extent from satellite imagery, Copper River Basin, Alaska (1973-2022)

description: The datasets included here were used to assess trends and geospatial patterns of river ice extent in the Copper River Basin of southcentral Alaska. Our goals were to document how river ice travel and wintertime access to traditional lands have been impacted by climate change, to support safe ice travel by identifying reaches with persistent open water vs early ice cover, and to understand the physical drivers of the local variation in freeze-up. Trends in ice extent for a section of the Copper River were analyzed using Landsat imagery from water years (WY, Oct. 1-Sep 30) 1973-2021. The direct observations of ice extent classes from each image date are provided (IceExtent_DirectObs.csv). These observations were gap-filled and summarized on a weekly basis, along with local air temperature metrics (IceExtent_AirTemps_Weekly_GapFilled.csv). Geospatial patterns of ice and open water extent for recent winters were assessed in two ways. First, we quantified reach-level late-winter open water extent of the Copper and Chitina rivers by digitizing Sentinel-2 multispectral images from WY 2018, 2020, and 2021, and combined these with river hydrologic and geomorphic characteristics (e.g. unit stream power, number of channels, river width, etc.). These data are provided in spatial (RiverReachData_Spatial.zip) and tabular (RiverReachData_Tabular.csv) formats. Second, we analyzed the progression of freeze-up by visualizing Sentinel-1 SAR imagery and compositing pixel-based classifications of water for Nov-Feb of WY 2018-2020 to show the seasonal and multiyear water occurrence (% season) (waterOccurrenceYYYY.tif, waterOccurrenceMultiYear.tif). The script for this SAR analysis in Google Earth Engine is provided (RiverIceAndOpenWater_SAR.js).
DOI: 10.25773/3g1y-t092
title: Dataset: Sea-level rise impacts on tidal marshes and estuarine biogeochemical processes
DOI: 10.5281/zenodo.6767362
title: Seismic Data from Temporary Seismic Observation in the Northeast Noto Peninsula, Central Japan

description: This seismic data is a part of a comprehensive study of ongoing seismic activity in the northeastern part of the Noto Peninsula, Central Japan, sponsored by the Ministry of Education, Culture, Sports, Science, and Technology (MEXT) Japan.
DOI: 10.6084/m9.figshare.22259590
title: Raw capture and radio-tracking data

description: Raw capture and radio-tracking data used in analyses, with specific locational data removed. Hourly weather data used (from Environment Canada) are also provided.
DOI: 10.6084/m9.figshare.23834667
title: Supplementary Material for: Granulocytic Sarcoma mimicking Cholesteatoma: beware the temporal bone in hematological patients

description: Granulocytic sarcoma is a myeloid neoplasm that can occur in isolation or in association with acute leukaemia. The temporal bone represents a sanctuary site for myeloid progenitors: granulocytic sarcoma may develop in this location before or concomitant with the onset of acute leukaemia. This atypical presentation with clinical and radiological data that closely mimic those of cholesteatoma often delay an accurate diagnosis. We here present the clinical case of a 28-year-old male with granulocytic sarcoma of the external auditory canal that preceded the relapse of promyelocytic leukaemia.