cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.8108141.v1
title: Supplementary Material for: Intensive versus Usual Control of Hypertension in the Prevention of Cardiovascular and Renal Outcomes: A Cumulative Meta-Analysis of Randomized Controlled Trials

description: <b><i>Background/Aims:</i></b> Previous studies have reported inconsistent results regarding the treatment effects of intensive blood pressure (IBP) control in the prevention of cardiovascular and renal outcomes. We conducted this cumulative meta-analysis to evaluate the treatment effects of IBP control on cardiovascular and renal outcomes. <b><i>Methods:</i></b> We systematically searched PubMed, EMBASE, and the Cochrane Library databases from the date of their inception to October 2017, to identify randomized controlled trials (RCTs). The relative risks (RRs) with corresponding 95% confidence intervals (CIs) were used to evaluate the treatment effects of IBP control by using a random-effects model. <b><i>Results:</i></b> The final analysis included 20 RCTs involving 56,687 individuals. The summary RRs indicated that IBP control treatment significantly reduced the risk of major cardiovascular events (RR: 0.85; 95% CI: 0.77–0.94; <i>p</i> = 0.001), including myocardial infarction (RR: 0.87; 95% CI: 0.76–1.00; <i>p</i> = 0.044), stroke (RR: 0.77; 95% CI: 0.66–0.89; <i>p</i> &lt; 0.001), and albuminuria (RR: 0.90; 95% CI: 0.84–0.97; <i>p</i> = 0.007). However, IBP control had no significant effect on heart failure (RR: 0.80; 95% CI: 0.62–1.03; <i>p</i> = 0.077), all-cause mortality (RR: 0.91; 95% CI: 0.81–1.02; <i>p</i> = 0.112), cardiac death (RR: 0.91; 95% CI: 0.75–1.12; <i>p</i> = 0.390), non-cardiac death (RR: 0.98; 95% CI: 0.86–1.12; <i>p</i> = 0.773), end-stage renal disease (RR: 0.90; 95% CI: 0.77–1.06; <i>p</i> = 0.203), and retinopathy (RR: 0.81; 95% CI: 0.66–1.00; <i>p</i> = 0.052). <b><i>Conclusion:</i></b> The findings of this study suggest that IBP control plays a beneficial role in the prevention of some major cardiovascular events, including myocardial infarction, stroke, and albuminuria.
DOI: 10.6084/m9.figshare.8108165.v1
title: Data set 2_Results table.xlsx

description: Bordetella pertussis proteins identified in analyzed aPv and wPv vaccines.
DOI: 10.6084/m9.figshare.8108096
title: Supplementary Material for: A Ferret Model of Encephalopathy of Prematurity

description: There is an ongoing need for relevant animal models in which to test therapeutic interventions for infants with neurological sequelae of prematurity. The ferret is an attractive model species as it has a gyrified brain with a white-to-gray matter ratio similar to that in the human brain. A model of encephalopathy of prematurity was developed in postnatal day 10 (P10) ferret kits, considered to be developmentally equivalent to infants of 24–26 weeks’ gestation. Cross-fostered P10 ferret kits received 5 mg/kg of lipopolysaccharide (LPS) before undergoing consecutive hypoxia-hyperoxia-hypoxia (60 min at 9%, 120 min at 60%, and 30 min at 9%). Control animals received saline vehicle followed by normoxia. The development of basic reflexes (negative geotaxis, cliff aversion, and righting) as well as gait coordination on an automated catwalk were assessed between P28 and P70, followed by ex vivo magnetic resonance imaging (MRI) and immunohistochemical analysis. Compared to controls, injured animals had slower overall reflex development between P28 and P40, as well as smaller hind-paw areas consistent with “toe walking” at P42. Injured animals also displayed significantly greater lateral movement during CatWalk assessment as a result of reduced gait coordination. Ex vivo MRI showed widespread white-matter hyperintensity on T2-weighted imaging as well as altered connectivity patterns. This coincided with white-matter dysmaturation characterized by increased intensity of myelin basic protein staining, white-matter thinning, and loss of oligodendrocyte transcription factor 2 (OLIG2)-positive cells. These results suggest both pathological and motor deficits consistent with premature white-matter injury. This newborn ferret model can therefore provide an additional platform to assess potential therapies before translation to human clinical trials.
DOI: 10.6084/m9.figshare.8108090
title: trial

description: This is a trial and I just want to see I can modify it
DOI: 10.6084/m9.figshare.8108096.v1
title: Supplementary Material for: A Ferret Model of Encephalopathy of Prematurity

description: There is an ongoing need for relevant animal models in which to test therapeutic interventions for infants with neurological sequelae of prematurity. The ferret is an attractive model species as it has a gyrified brain with a white-to-gray matter ratio similar to that in the human brain. A model of encephalopathy of prematurity was developed in postnatal day 10 (P10) ferret kits, considered to be developmentally equivalent to infants of 24–26 weeks’ gestation. Cross-fostered P10 ferret kits received 5 mg/kg of lipopolysaccharide (LPS) before undergoing consecutive hypoxia-hyperoxia-hypoxia (60 min at 9%, 120 min at 60%, and 30 min at 9%). Control animals received saline vehicle followed by normoxia. The development of basic reflexes (negative geotaxis, cliff aversion, and righting) as well as gait coordination on an automated catwalk were assessed between P28 and P70, followed by ex vivo magnetic resonance imaging (MRI) and immunohistochemical analysis. Compared to controls, injured animals had slower overall reflex development between P28 and P40, as well as smaller hind-paw areas consistent with “toe walking” at P42. Injured animals also displayed significantly greater lateral movement during CatWalk assessment as a result of reduced gait coordination. Ex vivo MRI showed widespread white-matter hyperintensity on T2-weighted imaging as well as altered connectivity patterns. This coincided with white-matter dysmaturation characterized by increased intensity of myelin basic protein staining, white-matter thinning, and loss of oligodendrocyte transcription factor 2 (OLIG2)-positive cells. These results suggest both pathological and motor deficits consistent with premature white-matter injury. This newborn ferret model can therefore provide an additional platform to assess potential therapies before translation to human clinical trials.
DOI: 10.6084/m9.figshare.8108042
title: Supplementary Material for: Cardiometabolic-Renal Disease in South Asians: Consensus Recommendations from the Cardio Renal Society of America

description: <b><i>Background:</i></b> Rates of cardiometabolic-renal disease are extremely high among South Asians (India, Pakistan, Bangladesh, Sri Lanka, Bhutan, the Maldives, and Nepal) residing in their home countries and worldwide. The Cardio Renal Society of America, National Kidney Foundation of Arizona, and Twinepidemic Inc. convened a task force to examine evidence and reach consensus regarding cardiometabolic-renal disease prevention in South Asians. The task force distilled the findings from 5 years of face-to-face and virtual meetings addressing questions derived from expert reviews of published data using the Delphi technique to create these consensus statements. <b><i>Summary:</i></b> Several high-quality observational studies document the high and increasing incidence and prevalence of cardiometabolic-renal disease among South Asians, starting well before adulthood, owing to genetic, cultural, and environmental factors. Despite the need for additional prospective studies, especially randomized trials, of educational, screening, and other prevention efforts, sufficient information is already available to expand and intensify ongoing efforts in professional and lay education to help control this epidemic. The task force proposes to provide this expansion over the next 10 years through scientific and lay publications and other educational programs to promote more effective action among the public, health care professionals, payers, and regulators in screening for and treating cardiometabolic-renal risk factors and preventing disease in South Asians, starting at an early age. <b><i>Key Messages:</i></b> These consensus statements describe risk factors and prognoses characteristic of South Asians regarding cardiometabolic-renal diseases, to aid physician decision-making, health care system delivery, and research initiatives to improve the quality of care for South Asians worldwide.
DOI: 10.6084/m9.figshare.8108042.v1
title: Supplementary Material for: Cardiometabolic-Renal Disease in South Asians: Consensus Recommendations from the Cardio Renal Society of America

description: <b><i>Background:</i></b> Rates of cardiometabolic-renal disease are extremely high among South Asians (India, Pakistan, Bangladesh, Sri Lanka, Bhutan, the Maldives, and Nepal) residing in their home countries and worldwide. The Cardio Renal Society of America, National Kidney Foundation of Arizona, and Twinepidemic Inc. convened a task force to examine evidence and reach consensus regarding cardiometabolic-renal disease prevention in South Asians. The task force distilled the findings from 5 years of face-to-face and virtual meetings addressing questions derived from expert reviews of published data using the Delphi technique to create these consensus statements. <b><i>Summary:</i></b> Several high-quality observational studies document the high and increasing incidence and prevalence of cardiometabolic-renal disease among South Asians, starting well before adulthood, owing to genetic, cultural, and environmental factors. Despite the need for additional prospective studies, especially randomized trials, of educational, screening, and other prevention efforts, sufficient information is already available to expand and intensify ongoing efforts in professional and lay education to help control this epidemic. The task force proposes to provide this expansion over the next 10 years through scientific and lay publications and other educational programs to promote more effective action among the public, health care professionals, payers, and regulators in screening for and treating cardiometabolic-renal risk factors and preventing disease in South Asians, starting at an early age. <b><i>Key Messages:</i></b> These consensus statements describe risk factors and prognoses characteristic of South Asians regarding cardiometabolic-renal diseases, to aid physician decision-making, health care system delivery, and research initiatives to improve the quality of care for South Asians worldwide.
DOI: 10.6084/m9.figshare.8107991
title: Supplementary Material for: Plasma Biomarkers in Predicting Renal Recovery from Acute Kidney Injury in Critically Ill Patients

description: <b><i>Background:</i></b> Numerous studies have suggested a possible role for acute kidney injury (AKI) biomarkers in predicting renal recovery both before and after renal replacement therapy (RRT). However, definitions for recovery and whether to include patients dying but free of RRT may influence results. <b><i>Objectives:</i></b> To validate plasma neutrophil gelatinase-associated lipocalin (pNGAL) as a useful biomarker for predicting or improving the ability of clinical predictors alone to predict recovery following AKI, including in our model plasma B-type natriuretic peptide (pBNP) to account for cardiovascular events. <b><i>Methods:</i></b> We analyzed 69 patients enrolled in the Acute Renal Failure Trial Network study. pNGAL and pBNP were measured on days 2, 7, and 14. We analyzed their predictive ability for subsequent recovery, defined as alive and independent from dialysis in 60 days. In sensitivity analyses, we explored changes in results with alternative definitions of recovery. <b><i>Results:</i></b> Twenty-nine patients (42%) recovered from AKI. Neither pNGAL nor pBNP, alone or in combination, was accurate predictors of renal recovery-the best area under the receiver-operating characteristics curve (AUC) was for pNGAL using the largest relative change (AUC 0.59, 95% CI 0.45–0.74). The best clinical model achieved superior performance to biomarkers (AUC 0.69, 95% CI 0.56–0.81). The AUC was greatest (0.75, 95% CI 0.60–0.91) when pNGAL + pBNP on day 14 were added to the clinical model but this increase did not achieve statistical significance. However, integrated discrimination improvement analysis showed that the addition of pNGAL and pBNP on day 14 to the clinical model significantly improved the prediction of renal recovery (<i>p</i> = 0.008). <b><i>Conclusions:</i></b> pNGAL and pBNP can improve the accuracy of clinical parameters in predicting AKI recovery and a full model using biomarkers together with age achieved adequate discrimination.
DOI: 10.6084/m9.figshare.8107991.v1
title: Supplementary Material for: Plasma Biomarkers in Predicting Renal Recovery from Acute Kidney Injury in Critically Ill Patients

description: <b><i>Background:</i></b> Numerous studies have suggested a possible role for acute kidney injury (AKI) biomarkers in predicting renal recovery both before and after renal replacement therapy (RRT). However, definitions for recovery and whether to include patients dying but free of RRT may influence results. <b><i>Objectives:</i></b> To validate plasma neutrophil gelatinase-associated lipocalin (pNGAL) as a useful biomarker for predicting or improving the ability of clinical predictors alone to predict recovery following AKI, including in our model plasma B-type natriuretic peptide (pBNP) to account for cardiovascular events. <b><i>Methods:</i></b> We analyzed 69 patients enrolled in the Acute Renal Failure Trial Network study. pNGAL and pBNP were measured on days 2, 7, and 14. We analyzed their predictive ability for subsequent recovery, defined as alive and independent from dialysis in 60 days. In sensitivity analyses, we explored changes in results with alternative definitions of recovery. <b><i>Results:</i></b> Twenty-nine patients (42%) recovered from AKI. Neither pNGAL nor pBNP, alone or in combination, was accurate predictors of renal recovery-the best area under the receiver-operating characteristics curve (AUC) was for pNGAL using the largest relative change (AUC 0.59, 95% CI 0.45–0.74). The best clinical model achieved superior performance to biomarkers (AUC 0.69, 95% CI 0.56–0.81). The AUC was greatest (0.75, 95% CI 0.60–0.91) when pNGAL + pBNP on day 14 were added to the clinical model but this increase did not achieve statistical significance. However, integrated discrimination improvement analysis showed that the addition of pNGAL and pBNP on day 14 to the clinical model significantly improved the prediction of renal recovery (<i>p</i> = 0.008). <b><i>Conclusions:</i></b> pNGAL and pBNP can improve the accuracy of clinical parameters in predicting AKI recovery and a full model using biomarkers together with age achieved adequate discrimination.
DOI: 10.6084/m9.figshare.8108090.v1
title: trial

description: This is a trial
DOI: 10.6084/m9.figshare.8108090.v3
title: trial

description: This is a trial and I just want to see I can modify it
DOI: 10.6084/m9.figshare.8108090.v2
title: trial edition

description: This is a trial and I just want to see I can modify it
DOI: 10.6084/m9.figshare.8107934
title: Supplementary Table 3 from Widespread selection for extremely high and low levels of secondary structure in coding sequences across all domains of life

description: (Absence of) Correlation between DBF-scores and gene expression
DOI: 10.6084/m9.figshare.8107937
title: Supplementary Table 1 from Widespread selection for extremely high and low levels of secondary structure in coding sequences across all domains of life

description: Distribution of DBF-scores per species
DOI: 10.6084/m9.figshare.8107931
title: Supplementary Table 2 from Widespread selection for extremely high and low levels of secondary structure in coding sequences across all domains of life

description: Correlation of DBF-scores of homologous coding sequences across different species
DOI: 10.6084/m9.figshare.8107928
title: Supplementary Table 5 from Widespread selection for extremely high and low levels of secondary structure in coding sequences across all domains of life

description: Enrichment of codons and amino acids in ORFs with high/low DBF-scores
DOI: 10.6084/m9.figshare.8107937.v1
title: Supplementary Table 1 from Widespread selection for extremely high and low levels of secondary structure in coding sequences across all domains of life

description: Distribution of DBF-scores per species
DOI: 10.6084/m9.figshare.8107922
title: Supplementary Table 4 from Widespread selection for extremely high and low levels of secondary structure in coding sequences across all domains of life

description: Estimates on the number of genes per species being subject to structural selection
DOI: 10.6084/m9.figshare.8107931.v1
title: Supplementary Table 2 from Widespread selection for extremely high and low levels of secondary structure in coding sequences across all domains of life

description: Correlation of DBF-scores of homologous coding sequences across different species
DOI: 10.6084/m9.figshare.8107934.v1
title: Supplementary Table 3 from Widespread selection for extremely high and low levels of secondary structure in coding sequences across all domains of life

description: (Absence of) Correlation between DBF-scores and gene expression
DOI: 10.6084/m9.figshare.8107919
title: Supplementary Material for: Long Noncoding RNA LINC00265 Promotes Glycolysis and Lactate Production of Colorectal Cancer through Regulating of miR-216b-5p/TRIM44 Axis

description: <b><i>Aim:</i></b> To examine the expression status of long-noncoding RNA LINC00265 and mechanistically elucidate its involvements in colorectal cancer (CRC). <b><i>Methods:</i></b> Relative abundances of LINC00265, miR-216b-5p, and tripartite-motif (TRIM)44 transcript were determined with real-time polymerase chain reaction. Cell viability was measured with cell counting kit-8 kit. Glucose uptake, pyruvate, and lactate production were quantified with commercially available kits. The potential regulatory effects of miR-216b-5p on both LINC00265 and TRIM44 were interrogated by luciferase reporter assay. The direct association between miR-216b-5p with both LINC00265 and TRIM44 was analyzed with pull-down assay. The TRIM44 protein was quantitated by western blotting. <b><i>Results:</i></b> LINC00265 was upregulated in CRC both in vivo and in vitro, which intimately associated with poorer prognosis. LINC00265-deficiency resulted into decreases in cell viability, glucose uptake, pyruvate production, and lactate production. Mechanistically, LINC00265 directly bound to miR-216b-5p and negatively regulated miR-216b-5p. Consequently, the suppression on TRIM44 expression was released. Supplementation with ectopic miR-216b-5p significantly compromised the oncogenic activities of LINC00265 in CRC cells. <b><i>Conclusion:</i></b> Our study highlighted the contribution of LINC00265/miR-216b-5p/TRIM44 signaling axis in CRC.
DOI: 10.6084/m9.figshare.8107922.v1
title: Supplementary Table 4 from Widespread selection for extremely high and low levels of secondary structure in coding sequences across all domains of life

description: Estimates on the number of genes per species being subject to structural selection
DOI: 10.6084/m9.figshare.8107910
title: Resting-state and vocabulary tasks distinctively inform on age-related differences in the functional brain connectome

description: Most of the current knowledge about age-related differences in brain neurofunctional organisation stems from neuroimaging studies using either a “resting state” paradigm, or cognitive tasks for which performance decreases with age. However, it remains to be known if comparable age-related differences are found when participants engage in cognitive activities for which performance is maintained with age, such as vocabulary knowledge tasks. A functional connectivity analysis was performed on 286 adults ranging from 18 to 80 years old, based on resting state or vocabulary tasks. Increases in connectivity of regions of the language network were observed during task completion. Conversely, only age-related decreases were observed during resting-state. While vocabulary accuracy increased with age, no interaction was found between functional connectivity, age and task accuracy or proxies of cognitive reserve, suggesting that older individuals typically benefits from semantic knowledge accumulated throughout one's life trajectory, without the need for compensatory mechanisms.
DOI: 10.6084/m9.figshare.8107916
title: Data

description: Data needed for analysis.<br>This data has already been prepared. The "original" data has not been shared
DOI: 10.6084/m9.figshare.8107928.v1
title: Supplementary Table 5 from Widespread selection for extremely high and low levels of secondary structure in coding sequences across all domains of life

description: Enrichment of codons and amino acids in ORFs with high/low DBF-scores
DOI: 10.6084/m9.figshare.8107895
title: data

description: Input data for the SysMalVac project.
DOI: 10.6084/m9.figshare.8107904
title: Evaluation of the published kinase inhibitor set to identify multiple inhibitors of bacterial ATP-dependent mur ligases

description: The Mur ligases form a series of consecutive enzymes that participate in the intracellular steps of bacterial peptidoglycan biosynthesis. They therefore represent interesting targets for antibacterial drug discovery. MurC, D, E and F are all ATP-dependent ligases. Accordingly, with the aim being to find multiple inhibitors of these enzymes, we screened a collection of ATP-competitive kinase inhibitors, on <i>Escherichia coli</i> MurC, D and F, and identified five promising scaffolds that inhibited at least two of these ligases. Compounds <b>1</b>, <b>2</b>, <b>4</b> and <b>5</b> are multiple inhibitors of the whole MurC to MurF cascade that act in the micromolar range (IC<sub>50</sub>, 32–368 µM). NMR-assisted binding studies and steady-state kinetics studies performed on aza-stilbene derivative <b>1</b> showed, surprisingly, that it acts as a competitive inhibitor of MurD activity towards D-glutamic acid, and additionally, that its binding to the D-glutamic acid binding site is independent of the enzyme closure promoted by ATP.
DOI: 10.6084/m9.figshare.8107916.v1
title: Data

description: Data needed for analysis.<br>This data has already been prepared. The "original" data has not been shared
DOI: 10.6084/m9.figshare.8107889
title: OGW_CFRP_Temperature_dam_D04

description: OGW_CFRP_Temperature_dam_D04
DOI: 10.6084/m9.figshare.8107910.v1
title: Resting-state and vocabulary tasks distinctively inform on age-related differences in the functional brain connectome

description: Most of the current knowledge about age-related differences in brain neurofunctional organisation stems from neuroimaging studies using either a “resting state” paradigm, or cognitive tasks for which performance decreases with age. However, it remains to be known if comparable age-related differences are found when participants engage in cognitive activities for which performance is maintained with age, such as vocabulary knowledge tasks. A functional connectivity analysis was performed on 286 adults ranging from 18 to 80 years old, based on resting state or vocabulary tasks. Increases in connectivity of regions of the language network were observed during task completion. Conversely, only age-related decreases were observed during resting-state. While vocabulary accuracy increased with age, no interaction was found between functional connectivity, age and task accuracy or proxies of cognitive reserve, suggesting that older individuals typically benefits from semantic knowledge accumulated throughout one's life trajectory, without the need for compensatory mechanisms.
DOI: 10.6084/m9.figshare.8107889.v1
title: OGW_CFRP_Temperature_dam_D04

description: OGW_CFRP_Temperature_dam_D04
DOI: 10.6084/m9.figshare.8107883
title: OGW_CFRP_Temperature_dam_D16

description: OGW_CFRP_Temperature_dam_D16