cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.8144519.v1
title: Table S2.docx

description: Arterial blood gas analysis of rats. Data are expressed as<i> mean</i> ± <i>SEM</i>, *<i>P</i>&lt;0.05 <i>VS</i> sham
DOI: 10.6084/m9.figshare.8144519.v2
title: Table S2.docx

description: Arterial blood gas analysis of rats.
DOI: 10.6084/m9.figshare.8144498
title: ADELEKAN SPSS.sav

description: The data set includes SPSS spreadsheet coding of primary data collected to establish the relationships between workforce diversity, job satisfaction and organisational commitment of public health workers in Lagos state, Nigeria
DOI: 10.6084/m9.figshare.8144492
title: Changes in human peripheral blood mononuclear cell (HPBMC) populations and T-cell subsets associated with arsenic and polycyclic aromatic hydrocarbon exposures in a Bangladesh cohort

description: 198 male study participants with urinary arsenic and PAH-adduct measurments. With cell surface marker and Th cell subset data. Also includes water arsenic exposure, age, smoking status and BMI.<br>
DOI: 10.6084/m9.figshare.8144492.v1
title: Changes in human peripheral blood mononuclear cell (HPBMC) populations and T-cell subsets associated with arsenic and polycyclic aromatic hydrocarbon exposures in a Bangladesh cohort

description: 198 male study participants with urinary arsenic and PAH-adduct measurments. With cell surface marker and Th cell subset data. Also includes water arsenic exposure, age, smoking status and BMI.<br>
DOI: 10.6084/m9.figshare.8144489
title: Supplementary data and R scripts for "Land-use change and the ecological consequences of personality in small mammals"

description: These data and scripts accompany the paper: "Brehm, A.M., Mortelliti, A., Maynard, G.A., & Zydlewski, J. (2019). Land-use change and the ecological consequences of personality in small mammals. Ecology Letters - In Press". This script can be used in concert with the supplemental data to replicate all main analyses in the paper. If additional comments or questions arise, please contact Alessio Mortelliti (alessio.mortelliti@maine.edu)
DOI: 10.6084/m9.figshare.8144489.v1
title: Supplementary data and R scripts for "Land-use change and the ecological consequences of personality in small mammals"

description: These data and scripts accompany the paper: "Brehm, A.M., Mortelliti, A., Maynard, G.A., & Zydlewski, J. (2019). Land-use change and the ecological consequences of personality in small mammals. Ecology Letters - In Press". This script can be used in concert with the supplemental data to replicate all main analyses in the paper. If additional comments or questions arise, please contact Alessio Mortelliti (alessio.mortelliti@maine.edu)
DOI: 10.6084/m9.figshare.8144291
title: HPO Predictions 01-02-2018

description: HPO prediction Z-scores<br>
DOI: 10.6084/m9.figshare.8144291.v1
title: HPO Predictions 01-02-2018

description: HPO prediction Z-scores<br>
DOI: 10.6084/m9.figshare.8144282
title: DomainSpacingFile

description: Domain spacing used to construct domain neighborhoods.
DOI: 10.6084/m9.figshare.8144282.v1
title: DomainSpacingFile

description: Domain spacing used to construct domain neighborhoods.
DOI: 10.6084/m9.figshare.8143949
title: data of shear torques and normal stresses.xlsx

description: The data describes the shear forces and normal stresses of the mass fraction of Fe<sub>3</sub>O<sub>4</sub> Nano-particles（respectively 0%, 4%, 7%, 12%, 16%）in MR fluid under the applied magnetic induction intensity.<br>
DOI: 10.6084/m9.figshare.8143949.v1
title: data of shear torques and normal stresses.xlsx

description: The data describes the shear forces and normal stresses of the mass fraction of Fe<sub>3</sub>O<sub>4</sub> Nano-particles（respectively 0%, 4%, 7%, 12%, 16%）in MR fluid under the applied magnetic induction intensity.<br>
DOI: 10.6084/m9.figshare.8143871
title: result1.txt

description: islet
DOI: 10.6084/m9.figshare.8143871.v2
title: result1.txt

description: islet
DOI: 10.6084/m9.figshare.8143871.v1
title: result1.txt

description: islet
DOI: 10.6084/m9.figshare.8143835
title: Salonen et al. Breed differences of heritable behaviour traits in cats - data

description: Data for Salonen, M., Vapalahti, K., Tiira, K., Mäki-Tanila, A., & Lohi, H. (2019). Breed differences of heritable behaviour traits in cats. <i>Accepted in Scientific Reports.</i><br>
DOI: 10.6084/m9.figshare.8143751
title: Combat-TB-NeoDB Elasticsearch Data

description: NeoDB is a free and open source integrated M.tuberculosis ‘omics’ knowledge-base. NeoDB is based on Neo4j and enables researchers to execute complex federated queries by linking well-known, curated and widely used biological data resources, and supplementary TB variants data from published literature.
DOI: 10.6084/m9.figshare.8143751.v1
title: neodb-es-data.tar.bz2

description: NeoDB is a free and open source integrated M.tuberculosis ‘omics’ knowledge-base. NeoDB is based on Neo4j and enables researchers to execute complex federated queries by linking well-known, curated and widely used biological data resources, and supplementary TB variants data from published literature.
DOI: 10.6084/m9.figshare.8143751.v2
title: Combat-TB-NeoDB Elasticsearch Data

description: NeoDB is a free and open source integrated M.tuberculosis ‘omics’ knowledge-base. NeoDB is based on Neo4j and enables researchers to execute complex federated queries by linking well-known, curated and widely used biological data resources, and supplementary TB variants data from published literature.
DOI: 10.6084/m9.figshare.8143751.v3
title: Combat-TB-NeoDB Elasticsearch Data

description: NeoDB is a free and open source integrated M.tuberculosis ‘omics’ knowledge-base. NeoDB is based on Neo4j and enables researchers to execute complex federated queries by linking well-known, curated and widely used biological data resources, and supplementary TB variants data from published literature.
DOI: 10.6084/m9.figshare.8143676
title: Combat-TB-NeoDB Graph Database

description: NeoDB is a free and open source integrated M.tuberculosis ‘omics’ knowledge-base. NeoDB is based on Neo4j and enables researchers to execute complex federated queries by linking well-known, curated and widely used biological data resources, and supplementary TB variants data from published literature.
DOI: 10.6084/m9.figshare.8143676.v1
title: tbneodb.tar.bz2

description: NeoDB is a free and open source integrated M.tuberculosis ‘omics’ knowledge-base. NeoDB is based on Neo4j and enables researchers to execute complex federated queries by linking well-known, curated and widely used biological data resources, and supplementary TB variants data from published literature.
DOI: 10.6084/m9.figshare.8143676.v2
title: NeoDB Graph Database

description: NeoDB is a free and open source integrated M.tuberculosis ‘omics’ knowledge-base. NeoDB is based on Neo4j and enables researchers to execute complex federated queries by linking well-known, curated and widely used biological data resources, and supplementary TB variants data from published literature.
DOI: 10.6084/m9.figshare.8143676.v3
title: Combat-TB-NeoDB Graph Database

description: NeoDB is a free and open source integrated M.tuberculosis ‘omics’ knowledge-base. NeoDB is based on Neo4j and enables researchers to execute complex federated queries by linking well-known, curated and widely used biological data resources, and supplementary TB variants data from published literature.
DOI: 10.6084/m9.figshare.8143676.v5
title: Combat-TB-NeoDB Graph Database

description: NeoDB is a free and open source integrated M.tuberculosis ‘omics’ knowledge-base. NeoDB is based on Neo4j and enables researchers to execute complex federated queries by linking well-known, curated and widely used biological data resources, and supplementary TB variants data from published literature.
DOI: 10.6084/m9.figshare.8143676.v4
title: Combat-TB-NeoDB Graph Database

description: NeoDB is a free and open source integrated M.tuberculosis ‘omics’ knowledge-base. NeoDB is based on Neo4j and enables researchers to execute complex federated queries by linking well-known, curated and widely used biological data resources, and supplementary TB variants data from published literature.
DOI: 10.6084/m9.figshare.8143631
title: Mid-lumbar vertebra of Mustela nivalis (ZMB Mam 56731)

description: Single Tiff file containing a stack of images corresponding to the scan of the mid-lumbar vertebra of Mustela nivalis (ZMB Mam 56731). The resolution of the stack was downgraded, and it has already been binarized, in order to reduced the size of the file.<br>
DOI: 10.6084/m9.figshare.8143568
title: Alignment ICME Catalogue

description: This catalogue lists observation times of ICME flux ropes observed by pairs of radially aligned spacecraft in the inner heliosphere. The ICMEs were observed 2007-2013 by alignments of the MESSENGER, Venus Express, STEREO-A, STEREO-B and Wind spacecraft. Further details of the catalogue may be found in '<i>Self-Similarity of ICME Flux Ropes: Observations by Radially Aligned Spacecraft in the Inner Heliosphere</i>', Good et al. 2019, JGR: Space Physics.
DOI: 10.6084/m9.figshare.8143568.v1
title: Alignment ICME Catalogue

description: This catalogue lists observation times of ICME flux ropes observed by pairs of radially aligned spacecraft in the inner heliosphere. The ICMEs were observed 2007-2013 by alignments of the MESSENGER, Venus Express, STEREO-A, STEREO-B and Wind spacecraft. Further details of the catalogue may be found in '<i>Self-Similarity of ICME Flux Ropes: Observations by Radially Aligned Spacecraft in the Inner Heliosphere</i>', Good et al. 2019, JGR: Space Physics.
DOI: 10.6084/m9.figshare.8143463
title: data of shear torque and normal stress.xlsx

description: The data describe the shear forces and normal stresses of the mass fraction of Fe<sub>3</sub>O<sub>4</sub> Nano-particles(respectively 0%, 4%, 7%, 12%, 16%）in MR fluid under the applied magnetic induction intensity.<b></b><i></i><sub></sub><sup></sup><br><b><br></b><br>
DOI: 10.6084/m9.figshare.8143463.v1
title: data of shear torque and normal stress.xlsx

description: The data describe the shear forces and normal stresses of the mass fraction of Fe<sub>3</sub>O<sub>4</sub> Nano-particles(respectively 0%, 4%, 7%, 12%, 16%）in MR fluid under the applied magnetic induction intensity.<b></b><i></i><sub></sub><sup></sup><br><b><br></b><br>
DOI: 10.14469/hpc/7318
title: Willgerodt-Kindler TS7 Full + NH3 G = -1338.173280 DG =16.6

description: Gaussian Calculation
DOI: 10.14469/hpc/7321
title: Willgerodt-Kindler Int6 Full + NH3 G = -1338.185776 DG = 8.8

description: Gaussian Calculation
DOI: 10.6084/m9.figshare.8143433
title: Applications of multiple reaction monitoring targeted proteomics assays in human plasma

description: <b>Introduction</b>: Multiple (or selected) reaction monitoring-mass spectrometry (MRM/SRM) is a targeted proteomic method that can be used for relative and absolute quantification. Multiple reports exist supporting the potential of the approach in proteomic biomarker validation. <b>Areas covered</b>: To get an overview of the applications of MRM in protein quantification in plasma, a search in MedLine/PubMed was performed using the keywords: ‘MRM/SRM plasma proteomic/proteomics/proteome’. The retrieved studies were further filtered to focus on disease biomarkers and the main results are summarized. <b>Expert opinion</b>: MRM is increasingly employed for the quantification of both well-established but also newly discovered putative biomarkers and occasionally their post-translationally modified forms in plasma. Fractionation is regularly required for the detection of low abundance proteins. Standardized procedures to facilitate assay establishment and marker quantification have been proposed and, in few cases, implemented. Nevertheless, in most cases, absolute quantification is not performed. To advance, multiple technical issues including the regular use of standard labeled peptides and appropriate quality controls to monitor assay performance should be considered. Additionally, clinical aspects involving careful study design to address biomarker clinical use should also be considered.
DOI: 10.6084/m9.figshare.8143433.v1
title: Applications of multiple reaction monitoring targeted proteomics assays in human plasma

description: <b>Introduction</b>: Multiple (or selected) reaction monitoring-mass spectrometry (MRM/SRM) is a targeted proteomic method that can be used for relative and absolute quantification. Multiple reports exist supporting the potential of the approach in proteomic biomarker validation. <b>Areas covered</b>: To get an overview of the applications of MRM in protein quantification in plasma, a search in MedLine/PubMed was performed using the keywords: ‘MRM/SRM plasma proteomic/proteomics/proteome’. The retrieved studies were further filtered to focus on disease biomarkers and the main results are summarized. <b>Expert opinion</b>: MRM is increasingly employed for the quantification of both well-established but also newly discovered putative biomarkers and occasionally their post-translationally modified forms in plasma. Fractionation is regularly required for the detection of low abundance proteins. Standardized procedures to facilitate assay establishment and marker quantification have been proposed and, in few cases, implemented. Nevertheless, in most cases, absolute quantification is not performed. To advance, multiple technical issues including the regular use of standard labeled peptides and appropriate quality controls to monitor assay performance should be considered. Additionally, clinical aspects involving careful study design to address biomarker clinical use should also be considered.
DOI: 10.6084/m9.figshare.8143409
title: GADO HPO Predictions 01-02-2018

description: Data used to run GADO command line: https://github.com/molgenis/systemsgenetics/wiki/GADO-Command-line
DOI: 10.6084/m9.figshare.8143409.v1
title: GADO HPO Predictions 01-02-2018

description: Data used to run GADO command line: https://github.com/molgenis/systemsgenetics/wiki/GADO-Command-line
DOI: 10.6084/m9.figshare.8143394
title: PTML model of drug-nanoparticle delivery system (OK)

description: PTML model of ChEMBL data of vitamins fused with coated nanoparticle data of biological activity.
DOI: 10.6084/m9.figshare.8143394.v2
title: PTML model of drug-nanoparticle delivery system (OK)

description: PTML model of ChEMBL data of vitamins fused with coated nanoparticle data of biological activity.
DOI: 10.6084/m9.figshare.8143394.v1
title: PTML model of vit-nanoparticle delivery system (OK)

description: PTML model of ChEMBL data of vitamins fused with coated nanoparticle data of biological activity.
DOI: 10.6084/m9.figshare.8143376
title: Comparative omics analyses of hepatotoxicity induced by oral azole drugs in mice liver and primary hepatocytes

description: Ketoconazole (KTZ) and itraconazole (ITZ) are antifungal agents that have a broad spectrum of activity against fungal pathogens. However, the therapeutic indications of many antifungal drugs, including those of the azole group, are restricted due to possible hepatotoxicity. We performed toxicogenomic analyses using <i>in vivo</i> and <i>in vitro</i> models to investigate the molecular mechanisms underlying the hepatotoxicity of two azole antifungal drugs. C57BL/6 male mice were treated daily with KTZ or ITZ, sacrificed at days 1 or 7, and the serum biochemistry and histopathology results showed that the KTZ-treated mice exhibited hepatotoxicity. Primary hepatocytes from C57BL/6 mice also exposed to KTZ or ITZ, and the cytotoxic effects of KTZ and ITZ were evaluated; KTZ exerted a greater cytotoxic effect than ITZ. The gene expression profiles in the livers of the 7-day-treated group and primary hepatocytes of the 24-h-treated group for both KTZ and ITZ were comparatively analyzed. Differentially expressed genes were selected based on the fold-changes and statistical significance, and the biological functions were analyzed using ingenuity pathways analysis. The results revealed that genes related to cholesterol synthesis were overexpressed in the liver in the KTZ-treated group, whereas expression of those related to acute phase injury was significantly altered in the ITZ-treated group. Causal gene analyses suggested that sterol regulatory element-binding transcription factors are key regulators that activate the transcription of target genes associated with the hepatotoxicity induced by oral KTZ. These findings enhance our understanding of the molecular mechanisms underlying the hepatotoxicity of azole drugs.
DOI: 10.6084/m9.figshare.8143376.v2
title: Comparative omics analyses of hepatotoxicity induced by oral azole drugs in mice liver and primary hepatocytes

description: Ketoconazole (KTZ) and itraconazole (ITZ) are antifungal agents that have a broad spectrum of activity against fungal pathogens. However, the therapeutic indications of many antifungal drugs, including those of the azole group, are restricted due to possible hepatotoxicity. We performed toxicogenomic analyses using <i>in vivo</i> and <i>in vitro</i> models to investigate the molecular mechanisms underlying the hepatotoxicity of two azole antifungal drugs. C57BL/6 male mice were treated daily with KTZ or ITZ, sacrificed at days 1 or 7, and the serum biochemistry and histopathology results showed that the KTZ-treated mice exhibited hepatotoxicity. Primary hepatocytes from C57BL/6 mice also exposed to KTZ or ITZ, and the cytotoxic effects of KTZ and ITZ were evaluated; KTZ exerted a greater cytotoxic effect than ITZ. The gene expression profiles in the livers of the 7-day-treated group and primary hepatocytes of the 24-h-treated group for both KTZ and ITZ were comparatively analyzed. Differentially expressed genes were selected based on the fold-changes and statistical significance, and the biological functions were analyzed using ingenuity pathways analysis. The results revealed that genes related to cholesterol synthesis were overexpressed in the liver in the KTZ-treated group, whereas expression of those related to acute phase injury was significantly altered in the ITZ-treated group. Causal gene analyses suggested that sterol regulatory element-binding transcription factors are key regulators that activate the transcription of target genes associated with the hepatotoxicity induced by oral KTZ. These findings enhance our understanding of the molecular mechanisms underlying the hepatotoxicity of azole drugs.
DOI: 10.6084/m9.figshare.8143307
title: Spreadsheet 2

description: Weather observations at Stellenbosch University's library.
DOI: 10.6084/m9.figshare.8143307.v1
title: Spreadsheet 2

description: Weather observations at Stellenbosch University's library.
DOI: 10.6084/m9.figshare.8143298
title: Supplementary Material for: Prevalence of Undiagnosed Hypothyroidism in Europe: A Systematic Review and Meta-Analysis

description: <b><i>Background:</i></b> Patients with undiagnosed hypothyroidism are not treated for the disease and are at high risk of developing serious complications, with major impact on public health. There is a need to systematically review the available evidence on this topic. <b><i>Objective:</i></b> To identify the prevalence of undiagnosed hypothyroidism in Europe. <b><i>Methods:</i></b> A systematic review of the literature (Medline, EMBASE, and Cochrane Central) was performed to identify epidemiological studies on the prevalence of undiagnosed hypothyroidism among European populations published between January 2008 and April 2018. The Newcastle-Ottawa Scale was used to assess the methodological quality of the included studies. Random-effects meta-analyses were performed to pool estimates of proportions (with 95% confidence intervals [CIs]) of undiagnosed (1) subclinical, (2) overt, and (3) total hypothyroidism. <b><i>Results:</i></b> The search returned 15,565 citations (4,526 duplicates). Twenty papers were included in the study. Fourteen and 6 studies were of good and moderate methodological quality, respectively. The results of the meta-analyses were as follows for the prevalence of undiagnosed hypothyroidism: subclinical, 4.11% (95% CI 3.05–5.31%, <i>I</i><sup>2</sup> = 99.32%); overt, 0.65% (95% CI 0.38–0.99%, <i>I</i><sup>2</sup> = 96.67%); and total, 4.70% (95% CI 2.98–6.79%, <i>I</i><sup>2</sup> = 99.53%). According to the sensitivity analysis, the prevalence of hypothyroidism tends to be higher in female patients, in those aged ≥65 years, among studies with lower sample sizes, in those with thyroid-stimulating hormone levels &lt;4.5 mIU/L, and in Eastern and Southern Europe. <b><i>Conclusions:</i></b> The current evidence suggests that a considerable proportion of the European population has hypothyroidism, particularly subclinical hypothyroidism, which is undiagnosed. This issue deserves further investigation because of possible deleterious consequences for public health.
DOI: 10.6084/m9.figshare.8143262
title: DataCarmonaJEcol2019.txt

description: Data on a plant competition experiment with eight annual species typical from Mediterranean grassland under two levels of fertilization. Each row corresponds to a pot; in each pot there is either a single individual of the focal species, or an individual of the focal species surrounded by six individuals of a competitor species. Traits of the focal individuals are measured in each pot.<br>
DOI: 10.6084/m9.figshare.8143172
title: Supplementary Material for: Distribution and Determinants of <b><i>Dermatophagoides</i></b> Mites Sensitization ofAllergic Rhinitis and Allergic Asthma in China

description: <b><i>Background:</i></b> The implementation of allergen immunotherapy (AIT) requires extensive knowledge of allergen distribution in the region to identify high-risk regions for AIT utilization. However, the geographical distribution patterns of the major <i>Dermatophagoides</i> allergens in China remain unclear despite the increasing prevalence of these allergens. <b><i>Methods:</i></b> We performed comprehensive database searches of articles demonstrating the distribution patterns of <i>Dermatophagoides</i>-sensitized allergic rhinitis (AR) and allergic asthma (AA) in China, published between 1990 and 2017. <b><i>Results:</i></b> We retrieved 163 articles encompassing 114,302 allergen-positive cases to generate the distribution maps. The rate of sensitization to <i>Dermatophagoides</i> <i>pteronyssinus</i>(<i>D. pteronyssinus</i>)<i></i>and <i>Dermatophagoides</i> <i>farinae</i> (<i>D. farinae</i>) was similar in patients with AR (75.1 vs. 75.2%, <i>p</i> &gt; 0.05) but not in those with AA (78.5 vs. 77.7%, <i>p</i> = 0.041). Patients with AR and AA shared similar regional distribution patterns of both <i>D. pteronyssinus</i> and <i>D. farinae</i> sensitization, which were highest in the southern and central parts of China and lowest in the northern regions, especially in the Northwest. The overall rate of sensitization to <i>D. pteronyssinus</i> and <i>D. farinae</i> was significantly higher in patients with AA (<i>p</i> &lt; 0.001). Additionally, the annual mean temperature and humidity were the 2 major determinants of <i>D. pteronyssinus</i> and <i>D. farinae</i> sensitization in AR and of <i>D. pteronyssinus</i> sensitization in AA, whereas the annual mean temperature was the sole determinant for <i>D. farinae</i> sensitization in AA. <b><i>Conclusion:</i></b> These findings may inform clinicians of the strategies for the prevention of <i>Dermatophagoides</i> sensitization and may be of benefit to the future clinical management of allergic diseases<i></i>associated with sensitization to <i>Dermatophagoides</i> mites.