DOI: 10.5061/dryad.cvdncjtbn
title: Data from: Ruthenium(II) complexes of curcumin and β-diketone derivatives: Effect of structural modifications on their cytotoxicity

description: Ruthenium(II) complexes (Ru1 - Ru3) with the general formula
 [Ru(O-O)(PPh3)2(bipy)]PF6, bearing two triphenylphosphine (PPh3),
 bipyridine (bipy), and a series of natural and synthetic β-diketones (O,O)
 ligands where synthesized and characterized using various analytical
 techniques. The interaction between the complexes and calf thymus DNA
 (CT-DNA) was investigated, and demonstrated a weak interaction. The
 cytotoxicity of the complexes was investigated against breast cancer cells
 (MDA-MB-231 and MCF-7), lung cancer cells (A549), cisplatin-resistant
 ovarian cancer cells (A2780cis), as well as non-tumor lung (MRC-5) and
 non-tumor breast (MCF-10A) cell lines. All complexes exhibited cytotoxic
 activity against all the cell lines studied, with IC50 values ranging from
 0.39 to 13 µM. Notably, the three complexes demonstrated selectivity
 against the A2780cis cell line, with IC50 ranging from 0.39 to 0.82 µM.
 Among them, Ru2 exhibited the highest cytotoxicity, with an IC50 value of
 0.39 µM. Consequently, this new class of complexes shows good selectivity
 towards cisplatin-resistant ovarian cancer cells, and it is promising for
 further investigation as anticancer agents.
description: # Data from: Ruthenium(II) complexes of curcumin and β-diketone
 derivatives: Effect of structural modifications on their cytotoxicity
 Dataset DOI:
 [10.5061/dryad.cvdncjtbn](https://doi.org/10.5061/dryad.cvdncjtbn) ##
 Description of the data and file structure Files are stored in
 Crystallography Information File (.CIF) format. ### Files and variables
 CheckCIF/PLATON reports and other supplementary materials can be found on
 Zenodo under the Supplemental information link. #### File: CIF_Ru2.cif
 **Description:** Crystal structure of the
 complex *[Ru(dbm)(PPh~3~)~2~(bipy)]PF~6 ~(**Ru2**).* #### File:
 CIF_Ru1.cif **Description:**  Crystal structure of the
 complex *[Ru(aca)(PPh~3~)~2~(bipy)]PF~6 ~(**Ru1**).* ## Code/software All
 data are provided in Crystallographic Information File (.CIF) format,
 which can be read using free and open-source crystallographic software.
 The .CIF files can be viewed and validated using Mercury (CCDC, version
 2023.x or later; free for academic use). Structure validation can be
 performed free with checkCIF. Structure solution and refinement were
 carried out using SHELXT for structure solution and SHELXL (version 2018/3
 or later) for refinement, as implemented within Olex2. No proprietary
 software is required to open, view, or assess the CIF files. The CIF files
 contain all necessary crystallographic parameters, refinement details, and
 metadata for independent inspection and reuse. No custom code or scripts
 are included with this submission. The workflow consists of direct loading
 of the CIF files into the software listed above for visualization,
 validation, and analysis. ## Access information Other publicly accessible
 locations of the data: * The copies of the data can be obtained free of
 charge via
 [https://www.ccdc.cam.ac.uk/structures/](https://www.ccdc.cam.ac.uk/structures/); CCDC 2335556 for **Ru1** and CCDC 2335557 for **Ru2**. Data was derived from the following sources: * *R Soc Open Sci.* (2024) 11 (7): 240353 - [https://doi.org/10.1098/rsos.240353](https://doi.org/10.1098/rsos.240353)