cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.25402/nnm.21131785
title: An Improved Oral Nutraceutical-Based Intervention for Management of Obesity: Pterostilbene Loaded Chitosan Nanoparticles - Supplementary tables.docx

description:       
<strong>Aim:</strong> To formulate and assess the oral   anti-obesity effect of polymeric-based Pterostilbene(PS)-nanoparticles.
<strong>Methods:</strong> Pterostilbene-hydroxypropyl   beta-cyclodextrin inclusion complex-loaded in chitosan-nanoparticles (PS/HPβCD-NPs) were   prepared and characterized <em>in-vitro</em>. Cytotoxicity, pharmacokinetics   and anti-obesity effects were assessed on Caco-2 cell line and high fat   diet-induced obesity. <em>In-vivo</em>   assessment included histological examination, protein and gene expression of   obesity biomarkers in adipose tissues.
<strong>Results:</strong> Safe PS/HPβCD-NPs were successfully prepared with improved   bioavailability compared to free PS. PS/HPβCD-NPs showed improved anti-obesity   effect supported by histological examination, lipid profile, <em>UCP1</em> gene   expression and protein expression of SIRT-1, COX-2, IL-6 and leptin. 
<strong>Conclusion: </strong>Orally administered PS   nanoparticles is a new and promising anti-obesity strategy owing to its   sustainable weight loss and minimal side effects which is of great   socio-economic impact.
<br>
      
Supplementary figure 1:  Transmission   electron microscope of a) Unloaded NP and b) Pt/HPβCD loaded NP at magnification 25,000x. The scale bar   represents 200 nm.
Supplementary   figure 2: a) Cellular uptake of free   C6, C6/HPßCD complex and C6/HPßCD-loaded NP (100 ng/mL C-6) in caco-2 cells using confocal laser microscopy and b)   Quantitative analysis of fluorescence intensity using Image J. Statistical   significance was shown at ***p≤0.001 and ****p≤0.0001 when compared to free   C-6<strong>.</strong>
Supplementary figure 3: a) Serum   lipid profile in rats of different experimental groups where b) VLDL-C , c)   LDL/HDL ratio and d) Total cholesterol were calculated and plotted against   time (4, 8 and 16 weeks). Each point represents the   mean ± SD of 8   samples. Statistical significance is shown where ****p≤0.0001,   ***p≤0.001, **p≤0.01 and *p≤0.05 when samples when compared to untreated HFD   groups.
DOI: 10.25549/examiner-c44-72993
title: Train wreck inquest, 1956

description: 26 images. Train wreck inquest, 3 February 1956. John England (Agent for Santa Fe); S. Ernest Roll; David Gardner (Engineer for Santa Fe); Frank Parrish (train engineer-defendant); inquest jury; Linwood Lester; Master Sergeant Virgil Connor; Malcomb Hobbs (sailor); Private James D. Lance; F.N. Stuppi (Santa Fe railroad); Private Richard V. Jackson; Arthur Murdock; Adolf Alexander; Virgil Cockrell; Win Stanley (Deputy Coroner); George Spickard (conductor); Homer Smith (fireman); William Hines (brakeman). (Sleeve reads: A-11701-025).; Caption slip reads: "Photographer: Monteverde. Date: 1956-02-03. Assignment: Train wreck. Jurors front row, (l to r) Ronald R. Ketcham, Fred A. McCanlies, W. Herbert Allen, C.S. McLean, [...] D. Ezell; back row, l to r. Homer L. Garrett, Earl Vaugh, [...] Sweeney, A.W. Anderson, Paul Sheely. Jury L to R. 31: Shows all witnesses seated; engineer in front center. 32/29/30: Blue ribbon jury. 8: Witness sailor Malcolmb Hobbs in back is Deputy Coroner Win Stanley - Ernie Roll. 7/21/22: Shows general scene of Santa Fe witness David Gardner, Division Eng inner & Ernie Roll pointing at rail map etc. Jury in right of pix. 27/28: Shows Ernie Roll handing photo of tracks to jury. David Gardner Santa Fe Division engineer explains to jury. 26: General view shows Arthur Murdock on stand - jury on right Adolph Alexander questioning from left. 25: L to R John England, special agent - Engineer Frank Parrish & Special Agent Virgil Cockrell of Santa Fe. 38/37: Train engineer Frank Parrish as he listens intently to testimony. 39: L to R. David Gardner explains meaning of "flange" marks on rail section (not from actual scene) Ernie Roll conducts questions. 23: Mr. F.N. Stuppi, Asst. Gen. Mgr. of Santa Fe, points to chart showing speed limits along route in question. 24: Arthur Murdock, road foreman of engineers. 19/20: Long shot shows entire room shown, Ernie Roll questioning Arthur Murdock of Santa Fe. 33/34: Geo Spickard, conductor & Homer Smith - fireman. 6: William Hines, brakeman. 5: Frank Parrish, engineer. 3: Linwood Lester, passenger on train. 4: M/Sgt. Vigril L. Connor, U.S.M.C. passenger. 14: Pvt. James D. Lance passenger from Camp Pendelton Marine base. 13: Pvt. Richard V. Jackson U.S.M.C. 50: F.N. Stuppi Asst Gen Mgr of Santa Fe. 49: F.N. Stuppi & Ernie Roll, D.A. - Roll holds Santa Fe time table & rules for employees
DOI: 10.15468/dl.j4q4s2
title: Occurrence Download

description: A dataset containing 4452 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is one of (Echinochloa pyramidalis (Lam.) Hitchc. & Chase)"
 ]
}

 The dataset includes 4452 records from 152 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0017266-240506114902167/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.25549/examiner-c44-52265
title: Mickey Cohen (assaulted Federal Narcotics Officer Howard Chappell), 1958

description: 5 images. Mickey Cohen (assaulted Federal Narcotics Officer Howard Chappell), 27 March 1958. Deputy Sheriff Jack Hutto; Mickey Cohen; Deputy Sheriff Lon Frank; Deputy Jack Sears; Attorney Edward Gritz; Deputy Marshall Charles Ross.; Caption slip reads: "Photographer: Mitchell. Date: 03-27. Reporter: Benson. Assignment: Cohen. 45: Jack Hutto; Mickey Cohen; Louis Frank. 46: Mickey Cohen".; Caption slip reads: "Photographer: Mitchell. Date: 1958-03-27. Reporter: Coney. Assignment: Mickey Cohen. 47 L to R: Deputy Marshall Jack Sears; Mickey Cohen; Attorney Edward I. Gritz; Deputy Marshall Charles Ross. 48-3-4: L to R. Attorney Edward I. Gritz; Mickey Cohen. 13: Deputy Marshall Charles Ross; Mickey Cohen; Deputy Marshall Jack Sears. 14: Mickey Cohen".; Caption slip reads: "Photographer: Hecht. Date: 1958-03-27. Reporter: Benson. Assignment: Mickey Cohen. 11-12-78: L to R -- Deputy Sheriff Jack Hutto, Mickey Cohen and Deputy Sheriff Lou Frank. Mickey Cohen".
DOI: 10.25402/nnm.21186325
title: Supplementary table - Alpha-fetoprotein mediated targeting of polymeric nanoparticles to treat solid tumors nnm-2022-0097

description: Background: Serious side effects caused by paclitaxel formulation, containing toxic solubilizer
Cremophor R ? EL, and its nonspecific accumulation greatly limit clinical paclitaxel application. Aim: To
design paclitaxel-loaded copolymer of lactic and glycolic acids nanoparticles decorated with alphafetoprotein
third domain (rAFP3d-NP) to increase paclitaxel safety profile. Methods: rAFP3d-NP was
obtained via carbodiimide technique. Results: The particles were characterized with high paclitaxel
loading content of 5% and size of 280 nm. rAFP3d-NP revealed biphasic profile with 67% release
of paclitaxel during 220 h. Increased area under the curveinf and mean residence time values after
rAFP3d-NP administration confirmed prolonged blood circulation compared with paclitaxel. rAFP3d-NP
demonstrated significant tumor growth inhibition at 4T1 and SKOV-3 models. Conclusion: rAFP3d-NP is
a promising delivery system for paclitaxel and can be applied similarly for delivery of other hydrophobic
drugs.
DOI: 10.25549/examiner-c44-73270
title: Forest Fire (Rim-of-the-World), 1953

description: 5 images. Forest Fire (Rim-of-the-World), 28 August 1953. General views.; Caption slip reads: "Photographer: Forbes. Date: 1953-08-28. Reporter: Ostler. Assignment: Rim Forest Fire. 2-201-202: Fire as it sweeps up Strawberry Peak. 129-130: Firefighters with hose fight back fire flames over edge of Rim of the World Highway. 209-210: Paul & Mary Gormley, Forest Service fire spotters of the Strawberry Peak Lookout station. 1: Men scaling mountain with ropes and ladder to get to fire area. 183-184: Strawberry Peak Lookout over Rim of the World hi way. 1: Scaling side of mt. at Strawberry Peak above Rim of World".
DOI: 10.25549/examiner-c44-18645
title: Yachts "Snowbird", 1949

description: 10 images. Yachts "Snowbird", 31 July 1949.; Supplementary material reads: "Start of 'Snowbird' class race, Balboa. 'Snowbird' class races -- Balboa". Note: Captions are from the negatives.
DOI: 10.15468/dl.gq9yx5
title: Occurrence Download

description: A dataset containing 340 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Luxiaria amasa (Butler, 1878)"
 ]
}

 The dataset includes 340 records from 27 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0017267-240506114902167/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.25402/nnm.21291120
title: Celastrol-based nanomedicine hydrogels eliminate posterior capsule opacification - Supplementary table

description: Aim: To formulate an injectable thermosensitive micelle–hydrogel hybrid system loaded with celastrol
(celastrol-loaded micelle hydrogel: CMG) to prevent posterior capsule opacification (PCO). Materials
& methods: Celastrol-loaded micelles were embedded in a thermosensitive hydrogel matrix to enable
controlled on-demand celastrol delivery into the residual capsule. The efficacy and mechanisms of the
system for eliminating PCO were evaluated in rabbits. Results: Celastrol-loaded micelles inhibited the
migration and proliferation of lens epithelial cells induced by TGF-β1. Celastrol prevents epithelial–
mesenchymal transition in lens epithelial cells induced by TGF-β1 through the TGF-β1/Smad2/3/TEAD1
signaling pathway. In vivo efficiency evaluations showed that CMG demonstrated an excellent inhibitory
effect on PCO in rabbits and had no obvious tissue toxicity. Conclusion: Injectable CMG may represent
a promising ophthalmic platform for preventing PCO. This versatile injectable micelle–hydrogel hybrid
represents a clinically relevant platform to achieve localized therapy and controlled release of drugs in
other disease therapies.
DOI: 10.25402/nnm.21291120.v1
title: Celastrol-based nanomedicine hydrogels eliminate posterior capsule opacification - Supplementary table

description: Aim: To formulate an injectable thermosensitive micelle–hydrogel hybrid system loaded with celastrol
(celastrol-loaded micelle hydrogel: CMG) to prevent posterior capsule opacification (PCO). Materials
& methods: Celastrol-loaded micelles were embedded in a thermosensitive hydrogel matrix to enable
controlled on-demand celastrol delivery into the residual capsule. The efficacy and mechanisms of the
system for eliminating PCO were evaluated in rabbits. Results: Celastrol-loaded micelles inhibited the
migration and proliferation of lens epithelial cells induced by TGF-β1. Celastrol prevents epithelial–
mesenchymal transition in lens epithelial cells induced by TGF-β1 through the TGF-β1/Smad2/3/TEAD1
signaling pathway. In vivo efficiency evaluations showed that CMG demonstrated an excellent inhibitory
effect on PCO in rabbits and had no obvious tissue toxicity. Conclusion: Injectable CMG may represent
a promising ophthalmic platform for preventing PCO. This versatile injectable micelle–hydrogel hybrid
represents a clinically relevant platform to achieve localized therapy and controlled release of drugs in
other disease therapies.
DOI: 10.25549/examiner-c44-11316
title: Broken water main at Yucca and Ivar, 1951

description: 26 images. Broken water main at Yucca and Ivar, 26 July 1951. Officer S.W. Stevenson; Jim Madden (Chief Engineer at Hollywood Knickerbocker Hotel); Irving Lerner.
DOI: 10.25402/nnm.21333276
title: Insights into the mapping of green synthesis conditions for ZnO nanoparticles and their toxicokinetics - Supplementary appendix

description: Research on ZnO nanoparticles (NPs) has broad medical applications. However, the green synthesis of ZnO
NPs involves a wide range of properties requiring optimization. ZnO NPs show toxicity at lower doses. This
toxicity is a function of NP properties and pharmacokinetics. Moreover, NP toxicity and pharmacokinetics
are affected by the species type and age of the animals tested. Physiologically based pharmacokinetic
(PBPK) modeling offers a mechanistic platform to scrutinize the colligative effect of the interplay between
these factors, which reduces the need for in vivo studies. This review provides a guide to choosing green
synthesis conditions that result in minimal toxicity using a mechanistic tool, namely PBPK modeling.
DOI: 10.25549/examiner-c44-52849
title: Baseball Dodgers at Vero Beach, 1958.

description: 11 images. Baseball Dodgers at Vero Beach, 21 February 1958. Fresco Thompson; Walt Alston; Don Newcombe; Joe Becker; Chuck Dressen; Johnny Podres; Carl Erskine; Clem Labine; Ed Roebuck; Roger Craig; Lommy Holmes. "Sports". (Sleeve reads: SP 12371).; Supplementary material reads: "International news photos. 235 East 45th Street, N.Y. City. Photographer: H. Scharfman. Date: 1958-02-21. Assignment: Dodgers Vero Beach, Fla. 2: Vice Pres. Fresco Thompson and Mgr Walt Alston. HS43/44: Don Newcombe pitching. HS6/5: Left to right: Coach Joe Becker, Mgr. Alston and Coach Dressen. 29: Left to right: Pitchers Podres, Newcombe, Erskine and Labine. HS35: Left to right: Pitchers Roebuck, Erskine, and Graig. 60: Ex Brave Mgr. Lommy Holmes now a Dodger scout, Mgr. Alston and ex Mgr. Dressen now a coach".
DOI: 10.25402/nnm.21409356
title: Triple-combination therapy for cutaneous leishmaniasis using detergent-free, hyaluronate-coated elastic nanovesicles - Supplementary data set

description: Aim: To develop and evaluate detergent-free, triple-drug-loaded, hyaluronate-coated elastic nanovesicles
(H-ENVs) for the topical treatment of cutaneous leishmaniasis. Materials & methods: H-ENVs were
developed and evaluated for vesicle size, entrapment efficiency, skin permeation and antileishmanial
potential. Results: A 15.7 and 28.6% decrease in the cytotoxicity of paromomycin and amphotericin B,
respectively, was observed in detergent-free ENVs compared with conventional ENVs. H-ENVs improved
the efficacy of paromomycin against promastigote and amastigote models of leishmaniasis by 4- and
7.5-fold, respectively. In vivo investigation of H-ENVs demonstrated efficient topical management of
cutaneous leishmaniasis. Conclusion: The results indicate the potential of H-ENVs as a safe topical
treatment choice for cutaneous leishmaniasis.
DOI: 10.25549/examiner-c44-36408
title: Cat show ...Hollywood, 1952

description: 10 images. Cat show ...Hollywood, 12 January 1952. Cat "Son of Don Roberto"; Gladys Smith (owner); "Billy Mitty O'Toole" (best white cat in show); "Cresthaven Sun Girl"; Paul Benfer -- 14 months; "Cresthaven Benedict".
DOI: 10.25402/nnm.21409356.v2
title: Triple-combination therapy for cutaneous leishmaniasis using detergent-free, hyaluronate-coated elastic nanovesicles - Supplementary data set

description: Aim: To develop and evaluate detergent-free, triple-drug-loaded, hyaluronate-coated elastic nanovesicles
(H-ENVs) for the topical treatment of cutaneous leishmaniasis. Materials & methods: H-ENVs were
developed and evaluated for vesicle size, entrapment efficiency, skin permeation and antileishmanial
potential. Results: A 15.7 and 28.6% decrease in the cytotoxicity of paromomycin and amphotericin B,
respectively, was observed in detergent-free ENVs compared with conventional ENVs. H-ENVs improved
the efficacy of paromomycin against promastigote and amastigote models of leishmaniasis by 4- and
7.5-fold, respectively. In vivo investigation of H-ENVs demonstrated efficient topical management of
cutaneous leishmaniasis. Conclusion: The results indicate the potential of H-ENVs as a safe topical
treatment choice for cutaneous leishmaniasis.
DOI: 10.25549/examiner-c44-35646
title: Trade-Technical Junior College honors 21 year olds, 1952

description: 3 images. Trade-Technical Junior College honors 21 year olds, 08 January 1952. John Kelly; Lola Smith; Alice Grennan; Leslie G. Stier (Director); Don Breitinger (President of Student Trades Council).
DOI: 10.25402/nnm.21494091
title: Targeted activation of HNF4α/HGF1/FOXA2 reverses hepatic fibrosis via exosome-mediated delivery of CRISPR/dCas9-SAM system - supplementary files

description: Aim: Hepatic fibrosis is one of the most common conditions worldwide, and yet no effective antifibrotic
therapy is available. This study aimed to reverse hepatic fibrosis via exosome-mediated delivery of the
CRISPR/dCas9-SAM system. Materials & methods: The authors constructed a modified-exosome delivery
system targeting hepatic stellate cells (HSCs), and constructed the CRISPR/dCas9-SAM system inducing
HSCs convert into hepatocyte-like cells in vitro and in vivo. Results: RBP4-modified exosomes could
efficiently load and deliver the CRISPR/dCas9 system to HSCs. The in vitro CRISPR/dCas9 system induced
the conversion from HSCs to hepatocyte-like cells via targeted activation of HNF4α/HGF1/FOXA2 genes.
Importantly, in vivo targeted delivery of this system significantly attenuated CCl4-induced hepatic fibrosis.
Conclusion: Targeted activation of HNF4α/HGF1/FOXA2 reverses hepatic fibrosis via exosome-mediated
delivery of the CRISPR/dCas9-SAM system, which provides a feasible antifibrotic strategy.
DOI: 10.25549/examiner-c44-52066
title: Joseph Scott funeral, 1958

description: 15 images. Joseph Scott funeral, 29 March 1958. Mr. and Mrs. Norwood Jaqua; Judge and Mrs. A.A. Scott; James Francis Cardinal McIntyre; Governor and Mrs. Goodwin Knight; Justice Marshall McComb; John Hearne; Stephen Gavin; Messenger George Scott; Mrs. Chick Ebbets; Cuthbert Scott; Mrs. Helen Zeimann; Bishop Timothy Manning.; Caption slip reads: "Photographer: Snow. Date: 1958-03-29. Reporter: Adler. Assignment: Scott funeral. 14-44 Family L to R: Mrs. Chick Ebbets; Cuthbert Scott; Mrs. Helen Ziemann; Howard Ziemann; Mrs. Norwood Jaqua; Mrs. A.A. Scott; Judge A.A. Scott. 24-23: Messenger George Scott celebrates mass. 31: Procession with Cardinal McIntyre leave church. On left Father James Hourihan, right is Messenger George Scott. 110: Cardinal McIntyre preforms absolution. Judge & Mrs. A.A. Scott at left. 43: Family arrival, no names. 32: Casket being taken from church. 13 L to R: Mrs. Norwood Jaqua; Norwood Jaqua; Mrs. A.A. Scott; Judge A.A. Scott as cardinal McIntyre enters church. 39 L to R: Henry L. Clark; Governor & Mrs. Goodwin Knight; Justice Marshall McComb; Attorney James Farraher; Irish Ambassador John Hearne; Stephen Gavin, executive assistant to Mayor Paulson".; Caption slip reads: "Photographer: Lapp. Date: 1958-03-29. Assignment: Scott funeral. 50-27-28: Procession into church. Develop 8 minutes. 5-6-7-8-55-56: General view. 49: Family gets out of car. 43: Bishop Timothy Manning blessing casket in Calvary Mausoleum -- Messenger George Scott right behind him. 17-18: Casket being taken into mausoleum. 13-14: Final blessing of casket under crypt opening by Messenger George Scott -- with Judge A.A. Scott behind. 12: Judge A.A. Scott comforting Messenger George Scott after latter breaks in tears following final blessing of casket under crypt opening".
DOI: 10.25402/nnm.21494091.v1
title: Targeted activation of HNF4α/HGF1/FOXA2 reverses hepatic fibrosis via exosome-mediated delivery of CRISPR/dCas9-SAM system - supplementary files

description: Aim: Hepatic fibrosis is one of the most common conditions worldwide, and yet no effective antifibrotic
therapy is available. This study aimed to reverse hepatic fibrosis via exosome-mediated delivery of the
CRISPR/dCas9-SAM system. Materials & methods: The authors constructed a modified-exosome delivery
system targeting hepatic stellate cells (HSCs), and constructed the CRISPR/dCas9-SAM system inducing
HSCs convert into hepatocyte-like cells in vitro and in vivo. Results: RBP4-modified exosomes could
efficiently load and deliver the CRISPR/dCas9 system to HSCs. The in vitro CRISPR/dCas9 system induced
the conversion from HSCs to hepatocyte-like cells via targeted activation of HNF4α/HGF1/FOXA2 genes.
Importantly, in vivo targeted delivery of this system significantly attenuated CCl4-induced hepatic fibrosis.
Conclusion: Targeted activation of HNF4α/HGF1/FOXA2 reverses hepatic fibrosis via exosome-mediated
delivery of the CRISPR/dCas9-SAM system, which provides a feasible antifibrotic strategy.
DOI: 10.25549/examiner-c44-18516
title: University of Southern California swimmers -- divers, 1949

description: 16 images. University of Southern California swimmers -- divers, 15 March 1949. Tom Hairabedian, Wally Wolf; Bob King (back stroke).
DOI: 10.25402/nnm.21608433
title: Bedaquiline fumarate microemulsion: formulation optimization, rheological characterization and in vitro studies - Supplementary data

description: Aim: Bedaquiline fumarate (BQF), an antitubercular drug, shows limited bioavailability due to solubilitylimited
intestinal absorption. In this research, the authors formulated a BQF-loaded microemulsion
to improve BQF’s oral bioavailability. Methods: Microemulsion was prepared by a spontaneous
emulsification method and evaluated for thermodynamic stability, size, dispersibility, transmittance,
rheology, microrheology, drug release, cytotoxicity and cellular uptake. Results: Microemulsion showed
an average globule size of 26.50 ± 6.29 nm with spherical geometry and revealed gel-sol-gel behavior
in microrheological studies. Cytotoxicity and cell uptake studies in Caco-2 cells showed that BQF
microemulsion was cytocompatible at the highest concentration of 500 μg/ml with significantly higher
cellular uptake than control. Conclusion: The present study indicates that BQF microemulsion could be
explored further for effective treatment of multidrug-resistant tuberculosis.
DOI: 10.25549/examiner-c44-17552
title: Marines gypped, 1951

description: 2 images. Marines gypped, 2 September 1951. S.L. McClary; Vernon Kilpatrick; Corporal Gale Eyer; Corporal Robert Monaghan; Corporal Ralph Clark; Sergeant John McMillan; Sergeant Robert Rainey; Private First Class Robert Milloy.
DOI: 10.25549/examiner-c44-109488
title: Democrats, 1954

description: 9 images. Democrats, 26 August 1954. William G. Bonnelli; Augustus Hawkins; Charles Wilson; Richard Richards; Elizabeth Snyder; Richard Graves; Don Bradley. ; Caption slip reads: "Photographer: Wyman. Date: 08-26. Reporter: Harmon. Assignment: Demos. [sic]. 27-28: William G. Bonnelli. 71-72: Augustus Hawkins, assemblyman. 61: Chas. Wilson, 66th Assembly District. 62: Richard Richards, State Senator candidate. 64: Richard Graves, left, Demo. cand. for governor, & Don Bradley, campaign manager. 69: Richard Graves, Demo. candidate for gov."
DOI: 10.25402/nnm.21695297
title: Multimodal molecular imaging in the second near-infrared window - Supplementary material

description: Near-infrared-II (NIR-II) fluorescence imaging has rapidly developed for the noninvasive investigation of
physiological and pathological activities in living organisms with high spatiotemporal resolution. However,
the penetration depth of fluorescence restricts its ability to provide deep anatomical information.
Scientists integrate NIR-II fluorescence imaging with other imaging modes (such as photoacoustic and
magnetic resonance imaging) to create multimodal imaging that can acquire detailed anatomical and
quantitative information with deeper penetration by using multifunctional probes. This review offers
a comprehensive picture of NIR-II-based dual/multimodal imaging probes and highlights advances in
bioimaging and therapy. In addition, seminal studies and trends in multimodal imaging probes activated
by NIR-II laser are summarized and several key points regarding future clinical translation are elucidated.