cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.5281/zenodo.12535905
title: Exploring the Molecular Pathways of the Activation Process on PPARγ Recurrent Bladder Cancer Mutants

description: The intricate involvement of Peroxisome Proliferator-Activated Receptor Gamma (PPARγ) in vital processes such as glucose homeostasis and adipogenesis is well established. However, its multifaceted role in cancer, particularly in luminal bladder cancer, remains a subject of intense debate. In this context, PPARγ’s overexpression and activation have been implicated in tumorigenesis. Notably, specific gain-of-function mutations (M280I, I290M, and T475M) within PPARγ’s ligand-binding domain have been pinpointed in bladder cancer, correlating with receptor activation. Nonetheless, the underlying molecular pathways prompted by these mutations remain obscure. Here, we employed a dual-basin structure-based model (db SBM) to unveil the intricate conformational dynamics that underlie the transition between PPARγ’s inactive and active states. Additionally, we explored the effects of the M280I, I290M, and T475M mutations on this pivotal process. Our findings concur with existing literature, revealing heightened ligand-independent transcriptional activity in the I290M and T475M mutants compared to other variants. Importantly, both mutants displayed enhanced stabilization of the active state relative to the wild-type receptor, and the I290M mutation promoted a remarkably specific transition route, rendering it a prime candidate for further investigation. Electrostatic analysis pinpointed the pivotal role of residues K303 and E488 in the activation cascade of I290M. This insight was substantiated by biophysical assays, as disruption of the K303-E488 interaction curtailed the thermal stabilization characteristic of the I290M mutation. These findings designate K303 and E488 as potential targets for inhibitors aimed at modulating PPARγ activation, with promising implications for refining bladder cancer prognosis. In sum, our study highlights the remarkable predictive capabilities achieved through the integration of simulation and cheminformatics methods, validated by biochemical experiments, to gain deeper insights into molecular mechanisms of activation and identify target residues for protein modulation.
DOI: 10.5281/zenodo.12535906
title: Exploring the Molecular Pathways of the Activation Process on PPARγ Recurrent Bladder Cancer Mutants

description: The intricate involvement of Peroxisome Proliferator-Activated Receptor Gamma (PPARγ) in vital processes such as glucose homeostasis and adipogenesis is well established. However, its multifaceted role in cancer, particularly in luminal bladder cancer, remains a subject of intense debate. In this context, PPARγ’s overexpression and activation have been implicated in tumorigenesis. Notably, specific gain-of-function mutations (M280I, I290M, and T475M) within PPARγ’s ligand-binding domain have been pinpointed in bladder cancer, correlating with receptor activation. Nonetheless, the underlying molecular pathways prompted by these mutations remain obscure. Here, we employed a dual-basin structure-based model (db SBM) to unveil the intricate conformational dynamics that underlie the transition between PPARγ’s inactive and active states. Additionally, we explored the effects of the M280I, I290M, and T475M mutations on this pivotal process. Our findings concur with existing literature, revealing heightened ligand-independent transcriptional activity in the I290M and T475M mutants compared to other variants. Importantly, both mutants displayed enhanced stabilization of the active state relative to the wild-type receptor, and the I290M mutation promoted a remarkably specific transition route, rendering it a prime candidate for further investigation. Electrostatic analysis pinpointed the pivotal role of residues K303 and E488 in the activation cascade of I290M. This insight was substantiated by biophysical assays, as disruption of the K303-E488 interaction curtailed the thermal stabilization characteristic of the I290M mutation. These findings designate K303 and E488 as potential targets for inhibitors aimed at modulating PPARγ activation, with promising implications for refining bladder cancer prognosis. In sum, our study highlights the remarkable predictive capabilities achieved through the integration of simulation and cheminformatics methods, validated by biochemical experiments, to gain deeper insights into molecular mechanisms of activation and identify target residues for protein modulation.
DOI: 10.15468/dl.ftjpgs
title: Occurrence Download

description: A dataset containing 87 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Senecio squalidus subsp. squalidus)",
 "HasCoordinate is true"
 ]
}

 The dataset includes 87 records from 2 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0093625-240506114902167/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.mp72js
title: Occurrence Download

description: A dataset containing 4588 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Pseudanthias squamipinnis (Peters, 1855)"
 ]
}

 The dataset includes 4588 records from 98 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0093626-240506114902167/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.s5d7bh
title: Occurrence Download

description: A dataset containing 23 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Senecio eremophilus var. eremophilus)",
 "HasCoordinate is true"
 ]
}

 The dataset includes 23 records from 8 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0093627-240506114902167/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.ryh6tc
title: Occurrence Download

description: A dataset containing 15 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is BOLD:ACE2972"
 ]
}

 The dataset includes 15 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0093628-240506114902167/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.18112/openneuro.ds004796.v1.0.7
title: A Polish Electroencephalography, Alzheimer’s Risk-genes, Lifestyle and Neuroimaging (PEARL-Neuro) Database
DOI: 10.57967/hf/2624
title: perfume
DOI: 10.15468/dl.ntjx7t
title: Occurrence Download

description: A dataset containing 6 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is BOLD:AAB3927"
 ]
}

 The dataset includes 6 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0093629-240506114902167/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.6084/m9.figshare.31353145
title: Supplementary Material for: Basilar Artery Dissection Diagnosed Using Fluid-attenuated Inversion Recovery and Managed with Stepwise Antithrombotic Therapy: A Case Report

description: Introduction: Basilar artery dissection (BAD) is a rare cause of brainstem infarction, presenting with nonspecific symptoms and subtle radiographic findings, resulting in diagnostic delays. In this case, we aim to highlight the value of fluid-attenuated inversion recovery (FLAIR) imaging in the early detection of BAD and evaluate the safety of a stepwise conservative treatment strategy. 
Case Presentation: We report a case of a middle-aged man with an acute brainstem infarction caused by isolated BAD. Initial magnetic resonance imaging revealed diffusion restriction in the pons and linear hyperintensity along the basilar artery on FLAIR imaging. Computed tomography angiogram revealed irregularity of the basilar artery lumen without aneurysmal dilation, which was then confirmed via digital subtraction angiography. The patient was managed conservatively with initial heparinization followed by cilostazol. Results of serial imaging showed no morphological progression, and the patient gradually improved, with only mild residual deficits. 
Conclusion: This case highlights the diagnostic value of FLAIR imaging in the early detection of BAD and supports the safety and potential efficacy of a conservative antiplatelet-based strategy in the absence of hemorrhagic risk.
DOI: 10.6084/m9.figshare.31353145.v1
title: Supplementary Material for: Basilar Artery Dissection Diagnosed Using Fluid-attenuated Inversion Recovery and Managed with Stepwise Antithrombotic Therapy: A Case Report

description: Introduction: Basilar artery dissection (BAD) is a rare cause of brainstem infarction, presenting with nonspecific symptoms and subtle radiographic findings, resulting in diagnostic delays. In this case, we aim to highlight the value of fluid-attenuated inversion recovery (FLAIR) imaging in the early detection of BAD and evaluate the safety of a stepwise conservative treatment strategy. 
Case Presentation: We report a case of a middle-aged man with an acute brainstem infarction caused by isolated BAD. Initial magnetic resonance imaging revealed diffusion restriction in the pons and linear hyperintensity along the basilar artery on FLAIR imaging. Computed tomography angiogram revealed irregularity of the basilar artery lumen without aneurysmal dilation, which was then confirmed via digital subtraction angiography. The patient was managed conservatively with initial heparinization followed by cilostazol. Results of serial imaging showed no morphological progression, and the patient gradually improved, with only mild residual deficits. 
Conclusion: This case highlights the diagnostic value of FLAIR imaging in the early detection of BAD and supports the safety and potential efficacy of a conservative antiplatelet-based strategy in the absence of hemorrhagic risk.
DOI: 10.17182/hepdata.110660.v1/t46
title: "Fig022-e" of "Constraints on anomalous Higgs boson couplings to vector bosons and fermions in its production and decay using the four-lepton final state"

description: Example description
description: No data abstract available.
DOI: 10.17182/hepdata.110660.v1/t47
title: "Fig022-d" of "Constraints on anomalous Higgs boson couplings to vector bosons and fermions in its production and decay using the four-lepton final state"

description: Example description
description: No data abstract available.
DOI: 10.17182/hepdata.110660.v1/t48
title: "Fig022-a" of "Constraints on anomalous Higgs boson couplings to vector bosons and fermions in its production and decay using the four-lepton final state"

description: Example description
description: No data abstract available.
DOI: 10.17182/hepdata.110660.v1/t49
title: "Fig022-f" of "Constraints on anomalous Higgs boson couplings to vector bosons and fermions in its production and decay using the four-lepton final state"

description: Example description
description: No data abstract available.
DOI: 10.17182/hepdata.110660.v1/t50
title: "Fig022-c" of "Constraints on anomalous Higgs boson couplings to vector bosons and fermions in its production and decay using the four-lepton final state"

description: Example description
description: No data abstract available.
DOI: 10.17182/hepdata.110660.v1/t51
title: "Fig022-b" of "Constraints on anomalous Higgs boson couplings to vector bosons and fermions in its production and decay using the four-lepton final state"

description: Example description
description: No data abstract available.
DOI: 10.17182/hepdata.110660.v1/t52
title: "Fig021-a" of "Constraints on anomalous Higgs boson couplings to vector bosons and fermions in its production and decay using the four-lepton final state"

description: Example description
description: No data abstract available.
DOI: 10.17182/hepdata.110660.v1/t53
title: "Fig021-b" of "Constraints on anomalous Higgs boson couplings to vector bosons and fermions in its production and decay using the four-lepton final state"

description: Example description
description: No data abstract available.
DOI: 10.17182/hepdata.110660.v1/t54
title: "Fig021-c" of "Constraints on anomalous Higgs boson couplings to vector bosons and fermions in its production and decay using the four-lepton final state"

description: Example description
description: No data abstract available.
DOI: 10.17182/hepdata.110660.v1/t55
title: "Fig021-d" of "Constraints on anomalous Higgs boson couplings to vector bosons and fermions in its production and decay using the four-lepton final state"

description: Example description
description: No data abstract available.
DOI: 10.17182/hepdata.110660.v1/t57
title: "Fig020-b" of "Constraints on anomalous Higgs boson couplings to vector bosons and fermions in its production and decay using the four-lepton final state"

description: Example description
description: No data abstract available.
DOI: 10.25549/vercoutere-ouc110610105
title: Let us make man in our likeness plus word salad

description: Five orange and yellow nude human bodies with all depicting internal organs or structures: one showing circulatory system to brain and legs with spine and pelvis bones; one depicting the chest and head area with spine and ribs; one depicting backside of a human with circulatory system to head, arms and legs, and musles in buttocks and back; one side view showing spine and ribs; one showing alimentary system, lungs, and kidneys. Word salad printed in blue on an unpainted background, including the words "Let us make man in our likeness and over the fish" and other words from Genesis. See description of 347 for OT notes.
DOI: 10.17182/hepdata.110660.v1/t56
title: "Fig020-a" of "Constraints on anomalous Higgs boson couplings to vector bosons and fermions in its production and decay using the four-lepton final state"

description: Example description
description: No data abstract available.
DOI: 10.17182/hepdata.110660.v1/t58
title: "Fig020-c" of "Constraints on anomalous Higgs boson couplings to vector bosons and fermions in its production and decay using the four-lepton final state"

description: Example description
description: No data abstract available.
DOI: 10.17182/hepdata.110660.v1/t59
title: "Fig018-a" of "Constraints on anomalous Higgs boson couplings to vector bosons and fermions in its production and decay using the four-lepton final state"

description: Example description
description: No data abstract available.
DOI: 10.17182/hepdata.110660.v1/t60
title: "Fig018-b" of "Constraints on anomalous Higgs boson couplings to vector bosons and fermions in its production and decay using the four-lepton final state"

description: Example description
description: No data abstract available.
DOI: 10.17182/hepdata.110660.v1/t61
title: "Fig018-c" of "Constraints on anomalous Higgs boson couplings to vector bosons and fermions in its production and decay using the four-lepton final state"

description: Example description
description: No data abstract available.
DOI: 10.17182/hepdata.110660.v1/t62
title: "Fig018-d" of "Constraints on anomalous Higgs boson couplings to vector bosons and fermions in its production and decay using the four-lepton final state"

description: Example description
description: No data abstract available.
DOI: 10.17182/hepdata.110660.v1/t63
title: "Fig019-d" of "Constraints on anomalous Higgs boson couplings to vector bosons and fermions in its production and decay using the four-lepton final state"

description: Example description
description: No data abstract available.
DOI: 10.17182/hepdata.110660.v1/t64
title: "Fig019-e" of "Constraints on anomalous Higgs boson couplings to vector bosons and fermions in its production and decay using the four-lepton final state"

description: Example description
description: No data abstract available.
DOI: 10.17182/hepdata.110660.v1/t65
title: "Fig019-a" of "Constraints on anomalous Higgs boson couplings to vector bosons and fermions in its production and decay using the four-lepton final state"

description: Example description
description: No data abstract available.
DOI: 10.17182/hepdata.110660.v1/t66
title: "Fig019-b" of "Constraints on anomalous Higgs boson couplings to vector bosons and fermions in its production and decay using the four-lepton final state"

description: Example description
description: No data abstract available.
DOI: 10.17182/hepdata.110660.v1/t67
title: "Fig019-c" of "Constraints on anomalous Higgs boson couplings to vector bosons and fermions in its production and decay using the four-lepton final state"

description: Example description
description: No data abstract available.
DOI: 10.17182/hepdata.110660.v1/t68
title: "Fig019-f" of "Constraints on anomalous Higgs boson couplings to vector bosons and fermions in its production and decay using the four-lepton final state"

description: Example description
description: No data abstract available.
DOI: 10.17182/hepdata.110665.v1/t1
title: "Table 1" of "Measurements of Z bosons plus jets using variables sensitive to double parton scattering in pp collisions at 13 TeV"

description: Differential cross sections as function of Delta Phi between Z boson and the leading jet for Z+ ≥ 1 jet events.
description: Double parton scattering is investigated using events with a Z boson and jets. The measurements are performed with proton-proton collision data recorded by the CMS experiment at the LHC at center-of-mass energy of 13 TeV corresponding to an integrated luminosity of 35.9 inverse femtobarns collected in year 2016. Differential cross section measurements of Z + ≥ 1 jet and Z+ ≥ 2 jet events are performed with transverse momenta of the jets above 20 GeV and pseudorapidity |eta| &lt; 2.4. Several distributions with sensitivity to double parton scattering effects are measured, as functions of the angle and the transverse momentum imbalance between the Z boson and the jets. The measured distributions are compared with predictions from several event generators with different hadronization models and different parameter settings for multiparton interactions. It is observed that the measured distributions show a dependence on the hadronization and multiparton interaction simulation parameters and will hence be important input for future improvements of the simulations.
DOI: 10.17182/hepdata.110661.v1/t1
title: "Table 1" of "First measurement of coherent $\rho^{0}$ photoproduction in ultra-peripheral Xe-Xe collisions at $\mathbf{\sqrt{s_{\rm {\scriptscriptstyle \mathbf{NN}}}} = 5.44}$ TeV"

description: Differential cross section as a function of rapidity for coherent RHO0 photoproduction in ultra-peripheral Xe-Xe collisions at ALICE.
description: No data abstract available.
DOI: 10.17182/hepdata.110665.v1/t2
title: "Table 2" of "Measurements of Z bosons plus jets using variables sensitive to double parton scattering in pp collisions at 13 TeV"

description: Differential cross sections as function of transverse momentum imbalance between Z boson and the leading jet for Z+ ≥ 1 jet events.
description: Double parton scattering is investigated using events with a Z boson and jets. The measurements are performed with proton-proton collision data recorded by the CMS experiment at the LHC at center-of-mass energy of 13 TeV corresponding to an integrated luminosity of 35.9 inverse femtobarns collected in year 2016. Differential cross section measurements of Z + ≥ 1 jet and Z+ ≥ 2 jet events are performed with transverse momenta of the jets above 20 GeV and pseudorapidity |eta| &lt; 2.4. Several distributions with sensitivity to double parton scattering effects are measured, as functions of the angle and the transverse momentum imbalance between the Z boson and the jets. The measured distributions are compared with predictions from several event generators with different hadronization models and different parameter settings for multiparton interactions. It is observed that the measured distributions show a dependence on the hadronization and multiparton interaction simulation parameters and will hence be important input for future improvements of the simulations.
DOI: 10.17182/hepdata.110665.v1/t3
title: "Table 3" of "Measurements of Z bosons plus jets using variables sensitive to double parton scattering in pp collisions at 13 TeV"

description: Differential cross sections as function of Delta Phi between Z boson and dijet for Z+ ≥ 2 jets events.
description: Double parton scattering is investigated using events with a Z boson and jets. The measurements are performed with proton-proton collision data recorded by the CMS experiment at the LHC at center-of-mass energy of 13 TeV corresponding to an integrated luminosity of 35.9 inverse femtobarns collected in year 2016. Differential cross section measurements of Z + ≥ 1 jet and Z+ ≥ 2 jet events are performed with transverse momenta of the jets above 20 GeV and pseudorapidity |eta| &lt; 2.4. Several distributions with sensitivity to double parton scattering effects are measured, as functions of the angle and the transverse momentum imbalance between the Z boson and the jets. The measured distributions are compared with predictions from several event generators with different hadronization models and different parameter settings for multiparton interactions. It is observed that the measured distributions show a dependence on the hadronization and multiparton interaction simulation parameters and will hence be important input for future improvements of the simulations.
DOI: 10.17182/hepdata.110665.v1/t5
title: "Table 5" of "Measurements of Z bosons plus jets using variables sensitive to double parton scattering in pp collisions at 13 TeV"

description: Differential cross sections as function of transverse momentum imbalance between leading and subleading jet for Z+ ≥ 2 jets events.
description: Double parton scattering is investigated using events with a Z boson and jets. The measurements are performed with proton-proton collision data recorded by the CMS experiment at the LHC at center-of-mass energy of 13 TeV corresponding to an integrated luminosity of 35.9 inverse femtobarns collected in year 2016. Differential cross section measurements of Z + ≥ 1 jet and Z+ ≥ 2 jet events are performed with transverse momenta of the jets above 20 GeV and pseudorapidity |eta| &lt; 2.4. Several distributions with sensitivity to double parton scattering effects are measured, as functions of the angle and the transverse momentum imbalance between the Z boson and the jets. The measured distributions are compared with predictions from several event generators with different hadronization models and different parameter settings for multiparton interactions. It is observed that the measured distributions show a dependence on the hadronization and multiparton interaction simulation parameters and will hence be important input for future improvements of the simulations.