cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.10073279
title: Association between Therapeutic Adherence and the Profile of Patients with Resistant Hypertension

description: Abstract Background: Resistant hypertension (RH) consists of increased blood pressure (BP) despite the use of 3 or more antihypertensives or BP control only when is use of 4 or more antihypertensives. It is fundamental to exclude pseudoresistance, which can be attributed to poor therapeutic adherence. Adherence evaluation, generally by the Morisky-Grenn test, is important because, when appropriate, it is associated with fewer cardiovascular complications and better BP control. Objectives: To evaluate the adherence of patients with RH and to investigate its relation with epidemiological, anthropometric and clinical characteristics, as well as to estimate the prevalence of pseudoresistance and to outline strategies to improve adherence. Methods: Retrospective observational cohort from an interview with patients followed at an outpatient clinic for RH. Therapeutic adherence, demographic, anthropometric data, cardiovascular risk factors, comorbidities, complementary exams and BP level were collected. One-way ANOVA and Student's t-tests were used for normal variables, and the Kruskal-Wallis and Mann-Whitney tests were used for non-normal tests. Categorical variables were compared using the Chi-Square test. We considered a 5% significance level in all tests. Results: 217 individuals were included. Of these, 17% had poor adherence. Epidemiological and clinical characteristics, complications, comorbidities, BP level or drugs used were statistically insignificant between groups. The poor adherence group used significantly more drugs (p = 0.0313) and 28% of pseudoresistance was estimated. Conclusions: Most of the individuals presented good therapeutic adherence by the Morisky test. Only the number of antihypertensive drugs had a statistically significant influence on adherence, while the epidemiological, anthropometric and clinical characteristics were statistically insignificant.
DOI: 10.6084/m9.figshare.10073285
title: Trends and Predictors of Oral Anticoagulation in Patients with Atrial Fibrillation: A Serial Cross-Sectional Study from 2011 to 2016

description: Abstract Background: Despite the efficacy of vitamin K antagonists against stroke in patients with atrial fibrillation (AF), the underuse of this therapy is well documented. Objectives: To evaluate trends and predictors of oral anticoagulants utilization in patients with AF. Methods: Observational, retrospective, serial cross-sectional study between 2011-2016. Comparisons between groups were performed using the Student t, Mann-Whitney and Chi-square tests. Logistic regression was used to identify independent predictors of anticoagulation. A p value &lt; 0.05 was considered significant. Results: A total of 377 patients were analyzed. The mean age was 70 ± 15 years; 52% were male and 75% were anticoagulated (20% with VKA and 55% with DOAC). Over 5 years, the overall frequency of anticoagulation increased by 22.4%. The use of DOACs increased from 29% to 70%, whereas the use of VKA decreased from 36% to 17%. The use of antiplatelet agents alone also fell from 21% to 6%. The predictors of anticoagulation were previous episodes of AF (OR 3.1, p &lt; 0.001), hypertension (OR 3.0, p &lt; 0.001) and HASBLED score (OR 0.5, p &lt; 0.001). The predictors of DOAC use were serum creatinine (OR 0.2, p = 0.002), left atrial size (OR 0.9, p = 0.003) and biological valve prosthesis (OR 0.1, p = 0.007). Of the 208 patients using DOACs, 63 (30%) received inadequate prescriptions: 5 with severe drug interactions and 58 with incorrect dosing. Conclusions: Between 2011 and 2016, DOACs were rapidly incorporated into clinical practice, replacing AVKs and antiplatelets, and contributing to greater use of anticoagulation in patients with AF.
DOI: 10.6084/m9.figshare.10073291.v1
title: Sgarbossa Criteria in Left Bundle Branch Block in a Hypertensive Emergency, a Case Report

description: Abstract Left bundle branch block and hypertensive emergency are very common conditions in clinical cardiovascular and emergency practice. Hypertensive emergency encompasses a spectrum of clinical presentations in which uncontrolled blood pressure leads to progressive end-organ dysfunction. Suspected acute myocardial infarction in the setting of a left bundle branch block presents a unique diagnostic and therapeutic challenge to the clinician. The diagnosis is especially difficult due to electrocardiographic changes caused by altered ventricular depolarization. However, reports on the use of the Sgarbossa’s criteria during the management of hypertensive emergency are rare. My current case is a hypertensive emergency patient with acute chest pain and left bundle branch block. Sgarbossa’s criteria were initially very weak and, over time, became highly suggestive of acute ST-segment elevation myocardial infarction. Interestingly, chest pain increased as the Sgarbossa’s diagnostic criteria were met. Here, we present a case of developing ST-segment elevation myocardial infarction with left bundle branch block that is indicating for thrombolytic therapy. Thrombolytic therapy was strongly indicated because of a higher developing of Sgarbossa criteria scoring. Thus, the higher Sgarbossa criteria scoring in the case was the only indication for thrombolytic. Therefore, how did Sgarbossa criteria developing during the course of the case to indicating the need for thrombolytic therapy?
DOI: 10.6084/m9.figshare.10073294.v1
title: Bioprosthesis versus Mechanical Valve Heart Prosthesis: Assessment of Quality of Life

description: Abstract Background: The aim of this study was to evaluate the QoL of patients undergoing heart valve replacement using the SF-36 questionnaire, compare it between patients with mechanical prosthesis and patients with bioprosthesis, and correlate the results with sociodemographic variables. Objective: To assess the QoL of patients undergoing heart valve replacement and compare it between patients with bioprosthetic valves and patients with mechanical prosthetic valves. Methods: We included 36 consecutive patients (16 men) with a mean age of 51 years and six months, who underwent mitral or aortic valve replacement from September 2007 to December 2011. The study was conducted between March and May 2012 and involved the application of the SF-36 survey and a sociodemographic questionnaire. Statistical tests were performed, and data are expressed as absolute frequency and percentile, and median and interquartile range (P25 and P75) (Mann-Whitney test), considering a significance of 95%. Results: The average time of surgery was 32.5 months (8-61 months). Participants were asked about the practice of physical activity, and 41.7% were physically active. For the SF-36 domains, the highest scores were observed for the social domain whereas the lowest scores were found for mental health, with a mean of 89.25 and 54.44, respectively. In the statistical analysis, we found statistically higher values in emotional functional for patients with mechanical valve prosthesis (p = 0.0084). Conclusion: The QoL of the patients undergoing heart valve replacement improves considerably after the surgery, except for the mental health domain, probably due to the low practice of physical activity. The type of prosthesis seems not to influence the QoL or the patients in the late postoperative period.
DOI: 10.6084/m9.figshare.10073285.v1
title: Trends and Predictors of Oral Anticoagulation in Patients with Atrial Fibrillation: A Serial Cross-Sectional Study from 2011 to 2016

description: Abstract Background: Despite the efficacy of vitamin K antagonists against stroke in patients with atrial fibrillation (AF), the underuse of this therapy is well documented. Objectives: To evaluate trends and predictors of oral anticoagulants utilization in patients with AF. Methods: Observational, retrospective, serial cross-sectional study between 2011-2016. Comparisons between groups were performed using the Student t, Mann-Whitney and Chi-square tests. Logistic regression was used to identify independent predictors of anticoagulation. A p value &lt; 0.05 was considered significant. Results: A total of 377 patients were analyzed. The mean age was 70 ± 15 years; 52% were male and 75% were anticoagulated (20% with VKA and 55% with DOAC). Over 5 years, the overall frequency of anticoagulation increased by 22.4%. The use of DOACs increased from 29% to 70%, whereas the use of VKA decreased from 36% to 17%. The use of antiplatelet agents alone also fell from 21% to 6%. The predictors of anticoagulation were previous episodes of AF (OR 3.1, p &lt; 0.001), hypertension (OR 3.0, p &lt; 0.001) and HASBLED score (OR 0.5, p &lt; 0.001). The predictors of DOAC use were serum creatinine (OR 0.2, p = 0.002), left atrial size (OR 0.9, p = 0.003) and biological valve prosthesis (OR 0.1, p = 0.007). Of the 208 patients using DOACs, 63 (30%) received inadequate prescriptions: 5 with severe drug interactions and 58 with incorrect dosing. Conclusions: Between 2011 and 2016, DOACs were rapidly incorporated into clinical practice, replacing AVKs and antiplatelets, and contributing to greater use of anticoagulation in patients with AF.
DOI: 10.6084/m9.figshare.10073279.v1
title: Association between Therapeutic Adherence and the Profile of Patients with Resistant Hypertension

description: Abstract Background: Resistant hypertension (RH) consists of increased blood pressure (BP) despite the use of 3 or more antihypertensives or BP control only when is use of 4 or more antihypertensives. It is fundamental to exclude pseudoresistance, which can be attributed to poor therapeutic adherence. Adherence evaluation, generally by the Morisky-Grenn test, is important because, when appropriate, it is associated with fewer cardiovascular complications and better BP control. Objectives: To evaluate the adherence of patients with RH and to investigate its relation with epidemiological, anthropometric and clinical characteristics, as well as to estimate the prevalence of pseudoresistance and to outline strategies to improve adherence. Methods: Retrospective observational cohort from an interview with patients followed at an outpatient clinic for RH. Therapeutic adherence, demographic, anthropometric data, cardiovascular risk factors, comorbidities, complementary exams and BP level were collected. One-way ANOVA and Student's t-tests were used for normal variables, and the Kruskal-Wallis and Mann-Whitney tests were used for non-normal tests. Categorical variables were compared using the Chi-Square test. We considered a 5% significance level in all tests. Results: 217 individuals were included. Of these, 17% had poor adherence. Epidemiological and clinical characteristics, complications, comorbidities, BP level or drugs used were statistically insignificant between groups. The poor adherence group used significantly more drugs (p = 0.0313) and 28% of pseudoresistance was estimated. Conclusions: Most of the individuals presented good therapeutic adherence by the Morisky test. Only the number of antihypertensive drugs had a statistically significant influence on adherence, while the epidemiological, anthropometric and clinical characteristics were statistically insignificant.
DOI: 10.6084/m9.figshare.10073273
title: Parotidectomy-related facial nerve lesions: proposal for a modified Sunnybrook Facial Grading System

description: ABSTRACT Facial nerve injury, affecting mainly the marginal mandibular branch, is the most frequent neurologic complication from parotidectomy. Objective To test a modified Sunnybrook Facial Grading System as a new tool to assess the facial nerve function following parotidectomy, emphasizing the marginal mandibular branch. Methods We reviewed the medical records of 73 post-parotidectomy patients (40 female, 18-84 years old, mean age 53.2 years) with facial nerve sparing, referred to the Department of Physical Therapy. All patients had parotid neoplasms or advanced skin cancer, and were followed by the principal author between 2006 and 2014. Results The muscles innervated by the marginal mandibular branch were the most frequently affected (72.6%), particularly in patients undergoing neck dissection (p = 0.023). The voluntary movement scores obtained with the modified system were significantly lower compared with the original version (p &lt; 0.001). The best and worst scores were observed in patients with benign parotid tumors and skin cancer, respectively. Patients requiring neck dissection (p = 0.031) and resection of other structures (p = 0.021) had the lowest scores, evidenced only with the modified version. Patients with malignant tumors had significantly worse ratings, regardless of the Sunnybrook system version. The post-physiotherapy analysis involved 50 patients. The worst facial rehabilitation outcomes were related to the marginal mandibular branch function. Conclusion The modified Sunnybrook Facial Grading System improved the marginal mandibular branch assessment, preserving the evaluation of other facial nerve branches.
DOI: 10.6084/m9.figshare.10073264
title: Raman Imaging Spectroscopy: History, Fundamentals and Current Scenario of the Technique

description: Raman imaging spectroscopy is a relatively new technique that has raised interest in several areas of knowledge due to the possibility of evaluating the spatial distribution of compounds based on their spectra. This paper presents a brief history of the development of this important technique, a theoretical description of the Raman effect and the preprocessing and processing (both univariate and multivariate) tools for Raman data. We also describe the current state of applications for major areas such as agriculture/biomass, environment, biology, medicine, pharmaceutical, geology, foodstuff, artwork, archaeology, material characterization and forensic.
DOI: 10.6084/m9.figshare.10073258
title: New nonlinear solution of nearly incompressible hyperelastic FGM cylindrical shells with arbitrary variable thickness and non-uniform pressure based on perturbation theory

description: Abstract In this paper, nonlinear analysis of thick cylindrical shells with arbitrary variable thickness made of hyperelastic FGM with radially variation of material properties in nearly incompressible state under non-uniform pressure loading is presented. Thickness and pressure of the shell vary in axial direction by linear and/or nonlinear functions. The governing equilibrium equations are derived based on shear deformation theory (SDT). The Mooney-Rivlin type material is considered which is a suitable hyperelastic model for rubbers. Boundary Layer Method of the perturbation theory which is known as Matched Asymptotic Expansion (MAE) is used for solving the governing equations. A new ingenious solution and formulation have been defined during current study to simplify and abbreviate the representation of inner and outer equations components in MAE. In order to validate the results of the current analytical solution, a numerical modeling based on Finite Element Method (FEM) have been investigated. Afterwards, for different rubber case studies, the effect of material constants, inhomogeneity index, geometry and pressure profiles on displacements, stresses and hydrostatic pressure distributions resulting from MAE and FEM solution have been illustrated. This approach enables insight into the nature of the deformation and stress distribution across the wall of rubber vessels and offers the potential for investigating the mechanical functionality of blood vessels such as arteries in physiological pressure range. The results prove the effectiveness of SDT and MAE combination to derive and solve the governing equations of nonlinear problems such as nearly incompressible hyperelastic FG shells.
DOI: 10.6084/m9.figshare.10073264.v1
title: Raman Imaging Spectroscopy: History, Fundamentals and Current Scenario of the Technique

description: Raman imaging spectroscopy is a relatively new technique that has raised interest in several areas of knowledge due to the possibility of evaluating the spatial distribution of compounds based on their spectra. This paper presents a brief history of the development of this important technique, a theoretical description of the Raman effect and the preprocessing and processing (both univariate and multivariate) tools for Raman data. We also describe the current state of applications for major areas such as agriculture/biomass, environment, biology, medicine, pharmaceutical, geology, foodstuff, artwork, archaeology, material characterization and forensic.
DOI: 10.6084/m9.figshare.10073273.v1
title: Parotidectomy-related facial nerve lesions: proposal for a modified Sunnybrook Facial Grading System

description: ABSTRACT Facial nerve injury, affecting mainly the marginal mandibular branch, is the most frequent neurologic complication from parotidectomy. Objective To test a modified Sunnybrook Facial Grading System as a new tool to assess the facial nerve function following parotidectomy, emphasizing the marginal mandibular branch. Methods We reviewed the medical records of 73 post-parotidectomy patients (40 female, 18-84 years old, mean age 53.2 years) with facial nerve sparing, referred to the Department of Physical Therapy. All patients had parotid neoplasms or advanced skin cancer, and were followed by the principal author between 2006 and 2014. Results The muscles innervated by the marginal mandibular branch were the most frequently affected (72.6%), particularly in patients undergoing neck dissection (p = 0.023). The voluntary movement scores obtained with the modified system were significantly lower compared with the original version (p &lt; 0.001). The best and worst scores were observed in patients with benign parotid tumors and skin cancer, respectively. Patients requiring neck dissection (p = 0.031) and resection of other structures (p = 0.021) had the lowest scores, evidenced only with the modified version. Patients with malignant tumors had significantly worse ratings, regardless of the Sunnybrook system version. The post-physiotherapy analysis involved 50 patients. The worst facial rehabilitation outcomes were related to the marginal mandibular branch function. Conclusion The modified Sunnybrook Facial Grading System improved the marginal mandibular branch assessment, preserving the evaluation of other facial nerve branches.
DOI: 10.6084/m9.figshare.10073258.v1
title: New nonlinear solution of nearly incompressible hyperelastic FGM cylindrical shells with arbitrary variable thickness and non-uniform pressure based on perturbation theory

description: Abstract In this paper, nonlinear analysis of thick cylindrical shells with arbitrary variable thickness made of hyperelastic FGM with radially variation of material properties in nearly incompressible state under non-uniform pressure loading is presented. Thickness and pressure of the shell vary in axial direction by linear and/or nonlinear functions. The governing equilibrium equations are derived based on shear deformation theory (SDT). The Mooney-Rivlin type material is considered which is a suitable hyperelastic model for rubbers. Boundary Layer Method of the perturbation theory which is known as Matched Asymptotic Expansion (MAE) is used for solving the governing equations. A new ingenious solution and formulation have been defined during current study to simplify and abbreviate the representation of inner and outer equations components in MAE. In order to validate the results of the current analytical solution, a numerical modeling based on Finite Element Method (FEM) have been investigated. Afterwards, for different rubber case studies, the effect of material constants, inhomogeneity index, geometry and pressure profiles on displacements, stresses and hydrostatic pressure distributions resulting from MAE and FEM solution have been illustrated. This approach enables insight into the nature of the deformation and stress distribution across the wall of rubber vessels and offers the potential for investigating the mechanical functionality of blood vessels such as arteries in physiological pressure range. The results prove the effectiveness of SDT and MAE combination to derive and solve the governing equations of nonlinear problems such as nearly incompressible hyperelastic FG shells.
DOI: 10.6084/m9.figshare.10073243
title: Feasibility of a New Method for Identification and Discrimination of Gunshot Residues by Total Reflection X-Ray Fluorescence and Principal Component Analysis

description: This study aims at identifying and discriminating gunshot residue (GSR) from conventional ammunition of six different calibers by total reflection X-ray fluorescence (TXRF) and pattern recognition by principal component analysis (PCA). GSR samples were collected from hands of volunteer shooters with swabs moistened with deionized water and were extracted with 5% v v-1 nitric acid. Aliquots were deposited on quartz disks for further determination by TXRF of the elements Al, S, Ca, K, Mn, Fe, Ni, Cu, Zn, Br, Sr, Sb, Ba and Pb, whose concentrations were imported into the MATLAB® software for PCA execution. The method proved to be adequate for identification of one- and three-shot residue inorganic components from .40, 9 mm, .380, .38 and .308 calibers, and of three-shot residues from .32 caliber, as well as for sample discrimination as a function of the conventional ammunition calibers studied.
DOI: 10.6084/m9.figshare.10073252
title: Aquatic Oligochaete Communities in Amazonian Streams, Saracá-Taquera National Forest, Pará, Brazil

description: Abstract: The aim of this study was to analyze aquatic oligochaete distribution in relation to water column physicochemical variables, structural environmental variation, and predominant substrates in the preserved Amazonian streams of the Saracá-Taquera National Forest (FLONA Saracá-Taquera), northwest Pará, Brazil. Oligochaetes are widely used as bioindicators for monitoring aquatic environments as they are very sensitive to pollution and environmental changes. Physicochemical and structural variables were measured from 100 stream segments in order to understand the distribution of oligochaetes in Amazonian streams. Biotic samples were collected using Surber samplers in three of the most predominant substrate types in each segment. PERMANOVA testing showed that there was a significant difference in the oligochaete community among some substrates, potentially caused by a difference in the abundance of the most common taxa. Canonical Correspondence Analysis showed that physical variables drive the distribution of oligochaetes in preserved Amazonian streams, as they determine the formation of different substrates along the stream, from the source to the mouth; favoring the presence of oligochaetes with more specific ecological needs in low-order streams, and the presence of oligochaetes capable of colonizing various types of substrates and deeper zones in high-order streams. These results suggest that water depth and channel width are the main drivers of aquatic oligochaete distribution along Amazonian streams, determining the formation of unstable and low-quality substrates and, consequently, the low colonization by oligochaetes in high-order streams; and more diverse and stable substrate formation in low-order streams, favoring the colonization by diverse taxa of aquatic oligochaetes in low-order Amazonian streams.