cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.5281/zenodo.7584148
title: Viral Agents and Systemic Levels of Inflammatory Cytokines in Vulnerable and Stable Atherosclerotic Carotid Plaques

description: Mazzaccaro D, Dolci M, Perego F, Delbue S, Giannetta M, Cardani R, Valentina Renna L, Costa E, Corsi-Romanelli MM, Galli C, Pariani E, Nano G, Clemente C, Basilico N. Viral Agents and Systemic Levels of Inflammatory Cytokines in Vulnerable and Stable Atherosclerotic Carotid Plaques. Ann Vasc Surg. 2022 May;82:325-333. doi: 10.1016/j.avsg.2021.10.070. Epub 2021 Dec 11. PMID: 34902464. Abstract <strong>Background: </strong>To investigate the presence of genetic material of viral agents and the serum level of inflammatory cytokines in patients submitted to carotid endarterectomy having vulnerable versus stable atherosclerotic plaques. <strong>Methods: </strong>Data of patients consecutively submitted to carotid endarterectomy for a significant stenosis from July 2019 to December 2019 were prospectively collected. The genetic material of Epstein-Barr (EBV), CitoMegalo (CMV), Herpes Simplex (HSV), Varicella-Zoster (VZV) and Influenza (IV) Viruses was searched in the patient's plaques, both in the "mid" of the plaque and in an adjacent lateral portion of no-plaque area. The serum levels of TNF-α, IL-1β, IL-6, IL10 and CCL5 were determined. The obtained results were then correlated to the histologic vulnerability of the removed carotid plaque. P values &lt; 0.05 were considered statistically significant. <strong>Results: </strong>Data of 50 patients were analyzed. A vulnerable plaque was found in 31 patients (62%). The genome of CMV, HSV, VZV and IV was not found in any of the vascular samples, while the EBV genome was found in the "mid" of 2 vulnerable plaques, but not in their respective control area. Eighty-two percent of patients who did not receive anti-IV vaccination (23/28) had vulnerable carotid plaque, compared with 36% of vaccinated patients (8/22, P = 0.001). Serum levels of TNF-α and IL-6 were higher in patients with a vulnerable plaque compared to patients with a stable plaque (73.6 ± 238.2 vs. 3.9 ± 13.1 pg/ml, P= 0.01, and 45.9 ± 103.6 vs. 10.1 ± 25.3 pg/ml, P= 0.01, respectively), independent of comorbidities, viral exposure or flu vaccination. <strong>Conclusions: </strong>The EBV genome was found in the "core" of 2 vulnerable carotid plaques, but not in their respective adjacent control. Influenza vaccination was associated with a lower incidence of carotid plaque vulnerability. Serum levels of TNF-α and IL-6 were higher in patients with a vulnerable plaque compared to patients with a stable plaque.
DOI: 10.6084/m9.figshare.21680636
title: Supplementary Material for: Proton beam therapy versus radiofrequency ablation for patients with treatment-naïve single hepatocellular carcinoma: a propensity score analysis

description: Introduction: Proton beam therapy (PBT) is known to be an effective locoregional treatment for hepatocellular carcinoma (HCC). However, few comparative studies in treatment-naïve cases have been reported. The aim of this study was to compare the survival outcomes of PBT with those of radiofrequency ablation (RFA) in patients with treatment-naïve solitary HCC. Methods: Ninety-five consecutive patients with treatment-naïve HCC, a single nodule measuring ≤5 cm in diameter, and a Child-Pugh score of ≤8 who were treated with PBT at the University of Tsukuba Hospital between 2001 and 2013 were enrolled in the study. In addition, 836 patients with treatment-naïve HCC treated by RFA at the University of Tokyo Hospital during the same period were analyzed as controls. Recurrence-free survival (RFS) and overall survival (OS) were compared in 83 patient pairs after propensity score matching. Results: The 1-year, 3-year, and 5-year RFS rates were 86.6%, 49.5%, and 35.5%, respectively, in the PBT group and 59.5%, 34.0%, and 20.9% in the RFA group (p = 0.058); the respective OS rates were 97.6%, 77.8%, and 57.1% in the PBT group and 95.1%, 81.7%, and 67.7% in the RFA group (p = 0.16). Regarding adverse effects, no grade 3 or higher adverse events were noted in the PBT; however, two grade 3 adverse events occurred within 30 days of RFA in the RFA group, one hemoperitoneum and one hemothorax.. Discussion/Conclusion: After propensity score matching, PBT showed no significant difference in RFS and OS compared to RFA. PBT can be an alternative for patients with solitary treatment-naïve HCC.
DOI: 10.17632/f65ysxxw5z.1
title: 18F-FDG PET/CT May Predict Tumor Type and Risk Score in Gestational Trophoblastic Disease

description: Purpose: The aim of this study was to investigate the role of 18F-FDG PET/CT in predicting pathological prognostic factors, including tumor type and International Federation of Gynecology and Obstetrics (FIGO) score, in gestational trophoblastic disease (GTD).

Methods: Retrospective monocentric study including 24 consecutive patients who underwent to 18F-FDG PET/CT from May 2005 to March 2021 for GTD staging purpose. The following semiquantitative PET parameters were measured from the primary tumor and used for the analysis: maximum standardized uptake value (SUVmax), SUVmean, metabolic tumor volume (MTV) and total lesion glycolisis (TLG). Statistical analysis included Spearman correlation coefficient to evaluate the correlations between imaging parameters and tumor type (nonmolar trophoblastic vs postmolar trophoblastic tumors) and risk groups (high vs low, defined according to the FIGO score), whereas area under the curve (AUC) of the receiver operating characteristic (ROC) curve was used to assess the predictive value of the PET parameters. Mann-Whitney U test was used to further describe the parameter's potential in differentiating the populations.

Results: SUVmax and SUVmean resulted fair (AUC, 0.783; 95% confidence interval [CI], 0.56-0.95) and good (AUC, 0.811; 95% CI, 0.59-0.97) predictors of tumor type, respectively, showing a low (ρ = 0.489, adjusted P = 0.030) and moderate (ρ = 0.538, adjusted P = 0.027) correlation. According to FIGO score, TLG was instead a fair predictor (AUC, 0.770; 95% CI, 0.50-0.99) for patient risk stratification.

Conclusions: 18F-FDG PET parameters have a role in predicting GTD pathological prognostic factors, with SUVmax and SUVmean being predictive for tumor type and TLG for risk stratification.
DOI: 10.17632/4md5mjzfww.1
title: Role of Machine Learning (ML)-Based Classification Using Conventional 18F-FDG PET Parameters in Predicting Postsurgical Features of Endometrial Cancer Aggressiveness

description: Purpose: to investigate the preoperative role of ML-based classification using conventional 18F-FDG PET parameters and clinical data in predicting features of EC aggressiveness.

Methods: retrospective study, including 123 EC patients who underwent 18F-FDG PET (2009-2021) for preoperative staging. Maximum standardized uptake value (SUVmax), SUVmean, metabolic tumour volume (MTV), and total lesion glycolysis (TLG) were computed on the primary tumour. Age and BMI were collected. Histotype, myometrial invasion (MI), risk group, lymph-nodal involvement (LN), and p53 expression were retrieved from histology. The population was split into a train and a validation set (80-20%). The train set was used to select relevant parameters (Mann-Whitney U test; ROC analysis) and implement ML models, while the validation set was used to test prediction abilities.

Results: on the validation set, the best accuracies obtained with individual parameters and ML were: 61% (TLG) and 87% (ML) for MI; 71% (SUVmax) and 79% (ML) for risk groups; 72% (TLG) and 83% (ML) for LN; 45% (SUVmax; SUVmean) and 73% (ML) for p53 expression.

Conclusions: ML-based classification using conventional 18F-FDG PET parameters and clinical data demonstrated ability to characterize the investigated features of EC aggressiveness, providing a non-invasive way to support preoperative stratification of EC patients.
DOI: 10.15129/ec6c0bec-0cbc-44ea-a9c0-3e345d9ec645
title: Supplementary material for: ''Three-dimensional Solid Particle Self-assembly in Thermovibrational Flow: The case with Unidirectional Temperature gradient and Concurrent Vibrations ''

description: The files appended with the .cfluid, xlsx and .csv can be visualized on Matlab or MS Excel, Many Figures were produced by visualizing the velocity field in Paraview. Simply click on the .foam files to visualise the data set. Note: Paraview must be installed.
DOI: 10.5281/zenodo.7584278
title: A Comparative Study of Multiple Electrode Aggregometry Technologies in Cardiac Surgery: Different Values, Same Clinical Relevance.

description: Mazzaccaro D, Dolci M, Perego F, Delbue S, Giannetta M, Cardani R, Valentina Renna L, Costa E, Corsi-Romanelli MM, Galli C, Pariani E, Nano G, Clemente C, Basilico N. Viral Agents and Systemic Levels of Inflammatory Cytokines in Vulnerable and Stable Atherosclerotic Carotid Plaques. Ann Vasc Surg. 2022 May;82:325-333. doi: 10.1016/j.avsg.2021.10.070. Epub 2021 Dec 11. PMID: 34902464. Abstract <strong>Background: </strong>To investigate the presence of genetic material of viral agents and the serum level of inflammatory cytokines in patients submitted to carotid endarterectomy having vulnerable versus stable atherosclerotic plaques. <strong>Methods: </strong>Data of patients consecutively submitted to carotid endarterectomy for a significant stenosis from July 2019 to December 2019 were prospectively collected. The genetic material of Epstein-Barr (EBV), CitoMegalo (CMV), Herpes Simplex (HSV), Varicella-Zoster (VZV) and Influenza (IV) Viruses was searched in the patient's plaques, both in the "mid" of the plaque and in an adjacent lateral portion of no-plaque area. The serum levels of TNF-α, IL-1β, IL-6, IL10 and CCL5 were determined. The obtained results were then correlated to the histologic vulnerability of the removed carotid plaque. P values &lt; 0.05 were considered statistically significant. <strong>Results: </strong>Data of 50 patients were analyzed. A vulnerable plaque was found in 31 patients (62%). The genome of CMV, HSV, VZV and IV was not found in any of the vascular samples, while the EBV genome was found in the "mid" of 2 vulnerable plaques, but not in their respective control area. Eighty-two percent of patients who did not receive anti-IV vaccination (23/28) had vulnerable carotid plaque, compared with 36% of vaccinated patients (8/22, P = 0.001). Serum levels of TNF-α and IL-6 were higher in patients with a vulnerable plaque compared to patients with a stable plaque (73.6 ± 238.2 vs. 3.9 ± 13.1 pg/ml, P= 0.01, and 45.9 ± 103.6 vs. 10.1 ± 25.3 pg/ml, P= 0.01, respectively), independent of comorbidities, viral exposure or flu vaccination. <strong>Conclusions: </strong>The EBV genome was found in the "core" of 2 vulnerable carotid plaques, but not in their respective adjacent control. Influenza vaccination was associated with a lower incidence of carotid plaque vulnerability. Serum levels of TNF-α and IL-6 were higher in patients with a vulnerable plaque compared to patients with a stable plaque.
DOI: 10.5281/zenodo.7584277
title: A Comparative Study of Multiple Electrode Aggregometry Technologies in Cardiac Surgery: Different Values, Same Clinical Relevance.

description: Mazzaccaro D, Dolci M, Perego F, Delbue S, Giannetta M, Cardani R, Valentina Renna L, Costa E, Corsi-Romanelli MM, Galli C, Pariani E, Nano G, Clemente C, Basilico N. Viral Agents and Systemic Levels of Inflammatory Cytokines in Vulnerable and Stable Atherosclerotic Carotid Plaques. Ann Vasc Surg. 2022 May;82:325-333. doi: 10.1016/j.avsg.2021.10.070. Epub 2021 Dec 11. PMID: 34902464. Abstract <strong>Background: </strong>To investigate the presence of genetic material of viral agents and the serum level of inflammatory cytokines in patients submitted to carotid endarterectomy having vulnerable versus stable atherosclerotic plaques. <strong>Methods: </strong>Data of patients consecutively submitted to carotid endarterectomy for a significant stenosis from July 2019 to December 2019 were prospectively collected. The genetic material of Epstein-Barr (EBV), CitoMegalo (CMV), Herpes Simplex (HSV), Varicella-Zoster (VZV) and Influenza (IV) Viruses was searched in the patient's plaques, both in the "mid" of the plaque and in an adjacent lateral portion of no-plaque area. The serum levels of TNF-α, IL-1β, IL-6, IL10 and CCL5 were determined. The obtained results were then correlated to the histologic vulnerability of the removed carotid plaque. P values &lt; 0.05 were considered statistically significant. <strong>Results: </strong>Data of 50 patients were analyzed. A vulnerable plaque was found in 31 patients (62%). The genome of CMV, HSV, VZV and IV was not found in any of the vascular samples, while the EBV genome was found in the "mid" of 2 vulnerable plaques, but not in their respective control area. Eighty-two percent of patients who did not receive anti-IV vaccination (23/28) had vulnerable carotid plaque, compared with 36% of vaccinated patients (8/22, P = 0.001). Serum levels of TNF-α and IL-6 were higher in patients with a vulnerable plaque compared to patients with a stable plaque (73.6 ± 238.2 vs. 3.9 ± 13.1 pg/ml, P= 0.01, and 45.9 ± 103.6 vs. 10.1 ± 25.3 pg/ml, P= 0.01, respectively), independent of comorbidities, viral exposure or flu vaccination. <strong>Conclusions: </strong>The EBV genome was found in the "core" of 2 vulnerable carotid plaques, but not in their respective adjacent control. Influenza vaccination was associated with a lower incidence of carotid plaque vulnerability. Serum levels of TNF-α and IL-6 were higher in patients with a vulnerable plaque compared to patients with a stable plaque.
DOI: 10.17031/63d79d96a1bcc
title: North Sea Decapoda Larvae_CPR

description: Excel file containing CPR data for area 50N to 58N, -1.5W to 4.5E, 2000 to 2020, sample level data (each sample being 1 row, equating to approx. 10 nautical miles of tow, 3m3 of filtered seawater), for total decapoda larvae. Values in column G indicate abundance (according to standard CPR methodology, see Richardson et al. 2006, Prog in Oceanog 68. 27-74), zero values are absence of taxon. The excel file consists of samples in rows, with the following information in columns - A: sample id B:midpoint of sample latitude in decimal degrees C:midpoint of sample longitude in decimal degrees D:midpoint of sample local date and time E:sample year F: sample month G:decapoda larvae
DOI: 10.5281/zenodo.7584360
title: Categorizing the Role of Respiration in Cardiovascular and Cerebrovascular Variability Interactions.

description: Porta A, Gelpi F, Bari V, Cairo B, De Maria B, Tonon D, Rossato G, Ranucci M, Faes L. Categorizing the Role of Respiration in Cardiovascular and Cerebrovascular Variability Interactions. IEEE Trans Biomed Eng. 2022 Jun;69(6):2065-2076. doi: 10.1109/TBME.2021.3135313. Epub 2022 May 19. PMID: 34905489. <strong>Abstract</strong> <strong>Objective: </strong>Respiration disturbs cardiovascular and cerebrovascular controls but its role is not fully elucidated. <strong>Methods: </strong>Respiration can be classified as a confounder if its observation reduces the strength of the causal relationship from source to target. Respiration is a suppressor if the opposite situation holds. We prove that a confounding/suppression (C/S) test can be accomplished by evaluating the sign of net redundancy/synergy balance in the predictability framework based on multivariate autoregressive modelling. In addition, we suggest that, under the hypothesis of Gaussian processes, the C/S test can be given in the transfer entropy decomposition framework as well. Experimental protocols: We applied the C/S test to variability series of respiratory movements, heart period, systolic arterial pressure, mean arterial pressure, and mean cerebral blood flow recorded in 17 pathological individuals (age: 64±8 yrs; 17 males) before and after induction of propofol-based general anesthesia prior to coronary artery bypass grafting, and in 13 healthy subjects (age: 27±8 yrs; 5 males) at rest in supine position and during head-up tilt with a table inclination of 60°. <strong>Results: </strong>Respiration behaved systematically as a confounder for cardiovascular and cerebrovascular controls. In addition, its role was affected by propofol-based general anesthesia but not by a postural stimulus of limited intensity. <strong>Conclusion: </strong>The C/S test can be fruitfully exploited to categorize the role of respiration over causal variability interactions. <strong>Significance: </strong>The application of the C/S test could favor the comprehension of the role of respiration in cardiovascular and cerebrovascular regulations.
DOI: 10.5281/zenodo.7584359
title: Categorizing the Role of Respiration in Cardiovascular and Cerebrovascular Variability Interactions.

description: Porta A, Gelpi F, Bari V, Cairo B, De Maria B, Tonon D, Rossato G, Ranucci M, Faes L. Categorizing the Role of Respiration in Cardiovascular and Cerebrovascular Variability Interactions. IEEE Trans Biomed Eng. 2022 Jun;69(6):2065-2076. doi: 10.1109/TBME.2021.3135313. Epub 2022 May 19. PMID: 34905489. <strong>Abstract</strong> <strong>Objective: </strong>Respiration disturbs cardiovascular and cerebrovascular controls but its role is not fully elucidated. <strong>Methods: </strong>Respiration can be classified as a confounder if its observation reduces the strength of the causal relationship from source to target. Respiration is a suppressor if the opposite situation holds. We prove that a confounding/suppression (C/S) test can be accomplished by evaluating the sign of net redundancy/synergy balance in the predictability framework based on multivariate autoregressive modelling. In addition, we suggest that, under the hypothesis of Gaussian processes, the C/S test can be given in the transfer entropy decomposition framework as well. Experimental protocols: We applied the C/S test to variability series of respiratory movements, heart period, systolic arterial pressure, mean arterial pressure, and mean cerebral blood flow recorded in 17 pathological individuals (age: 64±8 yrs; 17 males) before and after induction of propofol-based general anesthesia prior to coronary artery bypass grafting, and in 13 healthy subjects (age: 27±8 yrs; 5 males) at rest in supine position and during head-up tilt with a table inclination of 60°. <strong>Results: </strong>Respiration behaved systematically as a confounder for cardiovascular and cerebrovascular controls. In addition, its role was affected by propofol-based general anesthesia but not by a postural stimulus of limited intensity. <strong>Conclusion: </strong>The C/S test can be fruitfully exploited to categorize the role of respiration over causal variability interactions. <strong>Significance: </strong>The application of the C/S test could favor the comprehension of the role of respiration in cardiovascular and cerebrovascular regulations.
DOI: 10.5281/zenodo.7584062
title: Sea salt aerosol AOD at 550nm derived from MODIS

description: This dataset uses MODIS MOD08_M3 and MYD08_M3 data to derive monthly sea salt aerosol optical depth, using the Angstrom exponent as a filtering criterion. This dataset was created for the publication "The representation of sea salt aerosols and their role in polar climate within CMIP6", JGR: Atmospheres, 2023. The methodology for building this dataset is described in the publication, and the scripts used to do so can be found on GitHub at https://github.com/rlapere/CMIP6_SSA_Paper. The time period covered is 2005-2014, with a monthly time step. Warning: this dataset is only valid for polar regions, where sea salt dominate coarse mode aerosols. outside of 60-90N and 60-90S this product should not be used.
description: {"references": ["https://essopenarchive.org/doi/full/10.1002/essoar.10512918.1"]}
DOI: 10.48326/idoc.medoc.spice.3.0
title: Data issued from SPICE instrument on Solar Orbiter: 3rd data release
DOI: 10.15151/esrf-es-1022932361
title: Comparison of Pu-242 colloids and a mixture of Pu-242 and Pu-238 colloids in their structure and influence of radiolysis on stability

description: Due to the complex aqueous chemistry, plutonium is possible to form a wide variety of species. Plutonium colloids and their behaviour is of major concern for the safety assessment of nuclear waste repositories. In previous publications, different structures and an unexpected behaviour of the colloids during ageing were observed. The aged colloids showed structural changes in the form of disorder and changes in size. These observations were attributed to alpha radiation and recoil. Experiments will be conducted to investigate this hypothesis. Pu-242 colloids are prepared in three background media (HCl, HNO3 and HClO4) with different Pu concentrations to establish structural differences. In order to determine the influence of radiolysis on the structural changes of the colloids, the alpha activity is increased by adding Pu-238.
DOI: 10.15151/esrf-es-1022933606
title: Investigating giant directional asymmetry in superconductivity and magnetoresistance of Iridate/Cuprate heterostructures using X-ray absorpt

description: With X-ray Absorption Spectroscopy (XAS) at the Ir-L edge, we want to investigate heterostructures made from the cuprate high Tc superconductor YBa2Cu3O7 (YBCO) and Sr2IrO4 (SIO) that is a weak Mott-insulator with AF order and strong spin-orbit coupling. In particular, we will study how the charge transfer and orbital reconstruction at the YBCO/SIO interface influences the electronic/magnetic ground states. This information will provide important clues about the mechanism of the anomalous spin/charge coupling at the YBCO/SIO interface that results in a giant directional asymmetry of the superconducting and magneto-resistive response. In combination with XAS experiments at the Cu-L3 edge, we will be able to understand the magnetic and superconducting proximity effects at these interfaces.
DOI: 10.6084/m9.figshare.21975716
title: Transcriptomics_fullset_FPKM_r58395c252_randomfloor.csv

description: A total of 252 whole transcriptome sequencing (RNAseq) libraries from eight labs with either poly-A selection or rRNA-removal protocol were constructed.
DOI: 10.6084/m9.figshare.21975716.v1
title: Transcriptomics_fullset_FPKM_r58395c252_randomfloor.csv

description: A total of 252 whole transcriptome sequencing (RNAseq) libraries from eight labs with either poly-A selection or rRNA-removal protocol were constructed.
DOI: 10.5281/zenodo.7038124
title: Resistant and Misinformed: Understanding the Role of Elite Perceptions and Resistance Strategies against COVID-19 Reporting in Legacy Media in Adopting COVID-19 Misperceptions

description: The following dataset underlies the study " Resistant and Misinformed: Understanding the Role of Elite Perceptions and Resistance Strategies against COVID-19 Reporting in Legacy Media in Adopting COVID-19 Misperceptions". The data is published to allow for replicating and reviewing the analysis of our study.
DOI: 10.5281/zenodo.7038123
title: Resistant and Misinformed: Understanding the Role of Elite Perceptions and Resistance Strategies against COVID-19 Reporting in Legacy Media in Adopting COVID-19 Misperceptions

description: The following dataset underlies the study " Resistant and Misinformed: Understanding the Role of Elite Perceptions and Resistance Strategies against COVID-19 Reporting in Legacy Media in Adopting COVID-19 Misperceptions". The data is published to allow for replicating and reviewing the analysis of our study.
DOI: 10.6084/m9.figshare.21975728
title: Transcriptomics_Balanced_log2FPKM_r26907c45.csv

description: We selected 45 samples from 15 batches as study samples, including three samples in each batch from three sample groups (D5, F7, and M8). In each batch, three samples from one replicate of each sample group (D5-1, F7-1, and M8-1) were used in the balanced scenario.
DOI: 10.6084/m9.figshare.21975728.v1
title: Transcriptomics_Balanced_log2FPKM_r26907c45.csv

description: We selected 45 samples from 15 batches as study samples, including three samples in each batch from three sample groups (D5, F7, and M8). In each batch, three samples from one replicate of each sample group (D5-1, F7-1, and M8-1) were used in the balanced scenario.