cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.10265486
title: Comparative and quantitative assessment on statin efficacy and safety: insights into inter-statin and inter-individual variability via dose- and exposure-response relationships

description: <b>Introduction</b>: Statins are prescribed widely for cholesterol-lowering therapy, but it is known that their efficacy and safety profiles vary, despite the shared pharmacophore and pharmacological target. The immense body of related clinical and preclinical data offers a unique opportunity to explore the possible factors underlying inter-statin and inter-individual variabilities. <b>Area covered</b>: Clinical and preclinical data from various statins were compiled with regard to the efficacy (cholesterol-lowering effect) and safety (muscle toxicity). Based on the compiled data, dose- and exposure-response relationships were explored to obtain mechanistic and quantitative insights into the variations in the efficacy and safety profiles of statins. <b>Expert opinion</b>: Our analyses indicated that the inter-statin variability in the cholesterol-lowering effect may be mainly attributable to variations in potency of inhibition of the pharmacological target, rather than variations in drug exposure at the site of drug action. However, the drug exposure at the sites of drug action (i.e., the liver for efficacy and the muscle for safety) may contribute to the differences in the efficacy and safety observed in individual patients.
DOI: 10.6084/m9.figshare.10265486.v1
title: Comparative and quantitative assessment on statin efficacy and safety: insights into inter-statin and inter-individual variability via dose- and exposure-response relationships

description: <b>Introduction</b>: Statins are prescribed widely for cholesterol-lowering therapy, but it is known that their efficacy and safety profiles vary, despite the shared pharmacophore and pharmacological target. The immense body of related clinical and preclinical data offers a unique opportunity to explore the possible factors underlying inter-statin and inter-individual variabilities. <b>Area covered</b>: Clinical and preclinical data from various statins were compiled with regard to the efficacy (cholesterol-lowering effect) and safety (muscle toxicity). Based on the compiled data, dose- and exposure-response relationships were explored to obtain mechanistic and quantitative insights into the variations in the efficacy and safety profiles of statins. <b>Expert opinion</b>: Our analyses indicated that the inter-statin variability in the cholesterol-lowering effect may be mainly attributable to variations in potency of inhibition of the pharmacological target, rather than variations in drug exposure at the site of drug action. However, the drug exposure at the sites of drug action (i.e., the liver for efficacy and the muscle for safety) may contribute to the differences in the efficacy and safety observed in individual patients.
DOI: 10.11583/dtu.10265420.v1
title: Data for the paper: "A dual.reporter system for investigating and optimizing translation and folding in E.coli"

description: This is the supplementary data for "A dual-reporter system for investigating and optimizing protein translation and folding in E. coli"<br>
DOI: 10.6084/m9.figshare.10265396
title: Raw data: Optimization of glutaminase-free L-asparaginase production using mangrove endophytic Lysinibacillus fusiformis B27

description: The data consists ofAll 16 experiments resulting in micromoles ammoniaResults for confirmatory experimentimages of all 31 isolatesUncropped, unedited blots from genomeSequence of B27Uncropped, unedited image of Gram stain of B27, as shown in Figure 1B
DOI: 10.6084/m9.figshare.10265354

description: AFLP data for giant Senecio plant collected from East Africa high mountains
DOI: 10.6084/m9.figshare.10265354.v1
title: Afro-alpine flagships revisited: parallel adaptation, intermountain admixture and shallow genetic structuring in the giant senecios (Dendrosenecio)

description: AFLP data for giant Senecio plant collected from East Africa high mountains
DOI: 10.5522/04/10265318
title: ITPK1 mediates the lipid-independent synthesis of inositol phosphates controlled by metabolism.

description: These are the raw data used to generate all the figures presented in the manuscript "ITPK1 mediates the lipid-independent synthesis of inositol phosphates controlled by metabolism" (www.pnas.org/cgi/doi/10.1073/pnas.1911431116 ). All the methods used to generate the data are presented in the article which is available open access.
DOI: 10.6084/m9.figshare.10265336
title: Metadata record for: Eyasi Plateau Paleontological Expedition, Laetoli, Tanzania, fossil specimen database 1998-2005

description: This dataset contains key characteristics about the data described in the Data Descriptor Eyasi Plateau Paleontological Expedition, Laetoli, Tanzania, fossil specimen database 1998-2005. <br> Contents: <br> 1. human readable metadata summary table in CSV format 2. machine readable metadata file in JSON format <br> <br> Versioning Note:Version 2 was generated when the metadata format was updated from JSON to JSON-LD. This was an automatic process that changed only the format, not the contents, of the metadata.<br>
DOI: 10.6084/m9.figshare.10265330
title: Karyon: A scalable and easy to integrate ontology summarisation framework

description: Ontologies
DOI: 10.5522/04/10265318.v1
title: ITPK1 mediates the lipid-independent synthesis of inositol phosphates controlled by metabolism.

description: These are the raw data used to generate all the figures presented in the manuscript "ITPK1 mediates the lipid-independent synthesis of inositol phosphates controlled by metabolism" (www.pnas.org/cgi/doi/10.1073/pnas.1911431116 ). All the methods used to generate the data are presented in the article which is available open access.
DOI: 10.6084/m9.figshare.10265330.v1
title: Karyon: A scalable and easy to integrate ontology summarisation framework

description: Ontologies
DOI: 10.6084/m9.figshare.10265309
title: To give or not to take – insular cortex subserves framing-induced boosts in generosity during social discounting

description: Behavioral data of 4 studies about the framing effect on social discounting. Imaging data are available in XNAT Central (https://central.xnat.org/) under the project name ‘Framesocdisc’
DOI: 10.6084/m9.figshare.10265336.v2
title: Metadata record for: Eyasi Plateau Paleontological Expedition, Laetoli, Tanzania, fossil specimen database 1998-2005

description: This dataset contains key characteristics about the data described in the Data Descriptor Eyasi Plateau Paleontological Expedition, Laetoli, Tanzania, fossil specimen database 1998-2005. <br> Contents: <br> 1. human readable metadata summary table in CSV format 2. machine readable metadata file in JSON format <br> <br> Versioning Note:Version 2 was generated when the metadata format was updated from JSON to JSON-LD. This was an automatic process that changed only the format, not the contents, of the metadata.<br>
DOI: 10.6084/m9.figshare.10265336.v1
title: Metadata record for: Eyasi Plateau Paleontological Expedition, Laetoli, Tanzania, fossil specimen database 1998-2005

description: This dataset contains key characteristics about the data described in the Data Descriptor Eyasi Plateau Paleontological Expedition, Laetoli, Tanzania, fossil specimen database 1998-2005. <br> Contents: <br> 1. human readable metadata summary table in CSV format 2. machine readable metadata file in JSON format
DOI: 10.6084/m9.figshare.10265288
title: Supp Table 1: U–Pb igneous. Unravelling the Neoproterozoic Accretionary History of Oman, Using an Array of Isotopic Systems in Zircon.

description: Supp Table 1: U–Pb igneous
DOI: 10.6084/m9.figshare.10265291
title: Southern limit of Africanized honey bees in Argentina inferred by mtDNA and wing geometric morphometric analysis

description: African honey bee subspecies <i>Apis mellifera scutellata</i> began to spread in the American continent from southern Brazil in 1956. The process of Africanization involved both maternal and paternal bidirectional gene flow between European and Africanized honey bees. In Argentina, Africanized honey bees dominate in the northern semitropical regions and a hybrid area is defined between (<i>ca</i>. 32°–34°latitude). Although previous analysis has been carried out in Buenos Aires province, no analysis has been made south of this latitude. We used mitochondrial DNA (mtDNA) assays and wing geometric morphometrics to determine the prevalence of Africanized honey bees in managed populations. African mitotype origin and subspecies identity, were determined at three regions from Argentina. In our study, we analyzed 480 samples by wing morphometry and 157 by cytochrome-b assays, collected during 2013–2016. Our results show that North of 35°N latitude, honey bees with African mitotype were quite common (88.64%) finding high similarity with <i>A. m. scutellata</i>. South of that latitude, in temperate regions, we found African mitotype in only 18 of 133 colonies analyzed and a mixture of both European (<i>A. m. ligustica</i>, <i>A. m. cárnica</i>, <i>A. m. mellifera</i>) and African subspecies, most likely derived from North African honey bee (<i>A. m. intermissa</i>). Our results confirmed the existence of Africanized honey bee populations with a gradual cline from north to <b>s</b>outh, as a result from recent <i>A. m. scutellata</i>-derived bee expansion. Beyond the transition area between the 30°–35°S parallels bees carrying the European mitotype were fairly common.
DOI: 10.6084/m9.figshare.10265285
title: Supp Table 2: Oxygen. Unravelling the Neoproterozoic Accretionary History of Oman, Using an Array of Isotopic Systems in Zircon.

description: Supp Table 2: Oxygen
DOI: 10.6084/m9.figshare.10265288.v1
title: Supp Table 1: U–Pb igneous. Unravelling the Neoproterozoic Accretionary History of Oman, Using an Array of Isotopic Systems in Zircon.

description: Supp Table 1: U–Pb igneous
DOI: 10.6084/m9.figshare.10265285.v1
title: Supp Table 2: Oxygen. Unravelling the Neoproterozoic Accretionary History of Oman, Using an Array of Isotopic Systems in Zircon.

description: Supp Table 2: Oxygen
DOI: 10.6084/m9.figshare.10265291.v1
title: Southern limit of Africanized honey bees in Argentina inferred by mtDNA and wing geometric morphometric analysis

description: African honey bee subspecies <i>Apis mellifera scutellata</i> began to spread in the American continent from southern Brazil in 1956. The process of Africanization involved both maternal and paternal bidirectional gene flow between European and Africanized honey bees. In Argentina, Africanized honey bees dominate in the northern semitropical regions and a hybrid area is defined between (<i>ca</i>. 32°–34°latitude). Although previous analysis has been carried out in Buenos Aires province, no analysis has been made south of this latitude. We used mitochondrial DNA (mtDNA) assays and wing geometric morphometrics to determine the prevalence of Africanized honey bees in managed populations. African mitotype origin and subspecies identity, were determined at three regions from Argentina. In our study, we analyzed 480 samples by wing morphometry and 157 by cytochrome-b assays, collected during 2013–2016. Our results show that North of 35°N latitude, honey bees with African mitotype were quite common (88.64%) finding high similarity with <i>A. m. scutellata</i>. South of that latitude, in temperate regions, we found African mitotype in only 18 of 133 colonies analyzed and a mixture of both European (<i>A. m. ligustica</i>, <i>A. m. cárnica</i>, <i>A. m. mellifera</i>) and African subspecies, most likely derived from North African honey bee (<i>A. m. intermissa</i>). Our results confirmed the existence of Africanized honey bee populations with a gradual cline from north to <b>s</b>outh, as a result from recent <i>A. m. scutellata</i>-derived bee expansion. Beyond the transition area between the 30°–35°S parallels bees carrying the European mitotype were fairly common.
DOI: 10.6084/m9.figshare.10265273
title: Supp Table 3: Hf. Unravelling the Neoproterozoic Accretionary History of Oman, Using an Array of Isotopic Systems in Zircon.

description: Supp Table 3: Hf
DOI: 10.6084/m9.figshare.10265276
title: Supp Table 4: Detrital. Unravelling the Neoproterozoic Accretionary History of Oman, Using an Array of Isotopic Systems in Zircon.

description: Supp Table 4: Detrital
DOI: 10.6084/m9.figshare.10265273.v1
title: Supp Table 3: Hf. Unravelling the Neoproterozoic Accretionary History of Oman, Using an Array of Isotopic Systems in Zircon.

description: Supp Table 3: Hf
DOI: 10.6084/m9.figshare.10265276.v1
title: Supp Table 4: Detrital. Unravelling the Neoproterozoic Accretionary History of Oman, Using an Array of Isotopic Systems in Zircon.

description: Supp Table 4: Detrital
DOI: 10.6084/m9.figshare.10265234
title: Metadata record for: A database of high-resolution MS/MS spectra for lichen metabolites

description: This dataset contains key characteristics about the data described in the Data Descriptor A database of high-resolution MS/MS spectra for lichen metabolites. <br> Contents: <br> 1. human readable metadata summary table in CSV format 2. machine readable metadata file in JSON format <br> <br> Versioning Note:Version 2 was generated when the metadata format was updated from JSON to JSON-LD. This was an automatic process that changed only the format, not the contents, of the metadata.<br>
DOI: 10.6084/m9.figshare.10265234.v1
title: Metadata record for: A database of high-resolution MS/MS spectra for lichen metabolites

description: This dataset contains key characteristics about the data described in the Data Descriptor A database of high-resolution MS/MS spectra for lichen metabolites. <br> Contents: <br> 1. human readable metadata summary table in CSV format 2. machine readable metadata file in JSON format
DOI: 10.6084/m9.figshare.10265102
title: pSHDY*in_PpetE_BCD2_MrBBS_Strep

description: Shuttle plasmid used for Cu<sup>2+</sup>-induced overexpression of (-)-alpha-bisabolol synthase from <i>Matricaria chamomilla</i> <i>Mr</i>BBS in the cyanobacterium <i>Synechocystis </i>sp. PCC 6803.Basic plasmid backbone derived from pSHDY (w/o <i>mobA</i>Y25F point mutation):doi: https://doi.org/10.1101/757948
DOI: 10.6084/m9.figshare.10265072
title: pSHDY*in_PpetE_BCD2_mVenus.dna

description: Autonomous shuttle plasmid used for Cu<sup>2+</sup>-induced overexpression of a codon optimized mVenus reporter fluorophore in the cyanobacterium <i>Synechocystis </i>sp. PCC 6803.<br>Basic plasmid backbone derived from pSHDY (w/o <i>mobA</i>Y25F point mutation):doi: https://doi.org/10.1101/757948
DOI: 10.6084/m9.figshare.10265102.v1
title: pSHDY*in_PpetE_BCD2_MrBBS_Strep

description: Shuttle plasmid used for Cu<sup>2+</sup>-induced overexpression of (-)-alpha-bisabolol synthase from <i>Matricaria chamomilla</i> <i>Mr</i>BBS in the cyanobacterium <i>Synechocystis </i>sp. PCC 6803.Basic plasmid backbone derived from pSHDY (w/o <i>mobA</i>Y25F point mutation):doi: https://doi.org/10.1101/757948
DOI: 10.6084/m9.figshare.10265063
title: pSHDY*in_PpetE_BCD2_AgBIS_Flag.dna

description: Autonomous shuttle plasmid used for Cu<sup>2+</sup>-induced overexpression of bisabolene synthase from <i>Abies grandis</i> <i>Ag</i>BIS in the cyanobacterium <i>Synechocystis </i>sp. PCC 6803.Basic plasmid backbone derived from pSHDY (w/o <i>mobA</i>Y25F point mutation):doi: https://doi.org/10.1101/757948
DOI: 10.6084/m9.figshare.10265069
title: pSHDY*in_PpetE_BCD2_PcPs_Strep.dna

description: Shuttle plasmid used for Cu<sup>2+</sup>-induced overexpression of patchoulol synthase from <i>Pogostemon cablin (</i>P<i>c</i>P<i>s</i>) in the cyanobacterium <i>Synechocystis </i>sp. PCC 6803.Basic plasmid backbone derived from pSHDY (w/o <i>mobA</i>Y25F point mutation):doi: https://doi.org/10.1101/757948
DOI: 10.6084/m9.figshare.10264985
title: MS_8_sequence.zip

description: Latex from Tapping panel affected tree was collected and SmallRNA were extracted. The data represent the sequencing results.
DOI: 10.6084/m9.figshare.10264979
title: MS_1_sequence_plus.zip

description: SmallRNA from leaf, stem and root were extracted and sequenced.
DOI: 10.6084/m9.figshare.10264982
title: MS_s_8_sequence.zip

description: Latex from healthy trees was collected and smallRNA were extracted. The data represent the sequencing results.
DOI: 10.6084/m9.figshare.10264985.v1
title: MS_8_sequence.zip

description: Latex from Tapping panel affected tree was collected and SmallRNA were extracted. The data represent the sequencing results.
DOI: 10.6084/m9.figshare.10264976
title: DataAnalysis.zip

description: p.p1 {margin: 0.0px 0.0px 0.0px 0.0px; font: 10.0px Helvetica} This is the data analysis protocol and raw data that were presented in the manuscript entitled “Evolution of a novel and adaptive floral scent in wild tobacco” by Guo et.al in Molecular Biology and Evolution.
DOI: 10.6084/m9.figshare.10264979.v1
title: MS_1_sequence_plus.zip

description: SmallRNA from leaf, stem and root were extracted and sequenced.
DOI: 10.6084/m9.figshare.10264982.v1
title: MS_s_8_sequence.zip

description: Latex from healthy trees was collected and smallRNA were extracted. The data represent the sequencing results.
DOI: 10.6084/m9.figshare.10264976.v1
title: DataAnalysis.zip

description: p.p1 {margin: 0.0px 0.0px 0.0px 0.0px; font: 10.0px Helvetica} This is the data analysis protocol and raw data that were presented in the manuscript entitled “Evolution of a novel and adaptive floral scent in wild tobacco” by Guo et.al in Molecular Biology and Evolution.
DOI: 10.6084/m9.figshare.10264931
title: Inactivity in cattle_Individual duration datasheet

description: Individual duration datasheet
DOI: 10.6084/m9.figshare.10264943
title: Inactivity in cattle_Individual sample datasheet.xlsx

description: Individual sample datasheet
DOI: 10.6084/m9.figshare.10264925
title: Inactivity in cattle_Group sample datasheet.xlsx

description: Group sample datasheet
DOI: 10.6084/m9.figshare.10264943.v1
title: Supplementary file 3_Individual sample datasheet.xlsx

description: Individual sample datasheet
DOI: 10.6084/m9.figshare.10264913
title: Imputed WGS data of 626 birds

description: Genotype imputation was performed with two-step approach from 55 to 600 K, and then imputed to WGS. Before Genotype imputation, pre-phasing was executed in Beagle 4.1 with default parameter (Browning and Browning, 2016). Firstly, using 450 birds with 600 K chip data as a reference panel, these 194 birds were imputed from 55 K to 600 K chip data using Beagle 4.0 with pedigree. And then merge 600 K chip data of these 194 birds and 450 birds using VCFtools. Secondly, all of 644 birds with 600 K chip data were imputed to WGS data using a combined reference panel Beagle 4.1 with default parameter. The combined reference panels included 24 key individuals from the yellow-feather dwarf broiler population and 311 birds with WGS data from diverse chicken breeds. More detail information could be found in our previous study (Ye et al., 2019). After performed genotype imputation, quality control of the imputed WGS data was conducted using PLINK (Purcell et al., 2007) with the criteria of SNP call rate &gt; 95%, individual call rate &gt; 97%, MAF &gt; 0.5%, and Hardy-Weinberg equilibrium P-value &gt; 1.0e-6. In addition, individuals would be excluded who existed Mendelian errors. Finally, the remaining 626 individuals and 11,173,020 SNPs were used for further analysis.<br>
DOI: 10.6084/m9.figshare.10264925.v1
title: Supplementary file 1_Group sample datasheet.xlsx

description: Group sample datasheet
DOI: 10.6084/m9.figshare.10264931.v1
title: Individual duration datasheet

description: Individual duration datasheet
DOI: 10.6084/m9.figshare.10264904
title: Interview schedule

description: This data is the interview schedule for the study of surrogacy in Nigeria.
DOI: 10.6084/m9.figshare.10264931.v2
title: Individual duration datasheet

description: Individual duration datasheet
DOI: 10.6084/m9.figshare.10264943.v2
title: Individual sample datasheet.xlsx

description: Individual sample datasheet
DOI: 10.6084/m9.figshare.10264925.v2
title: Inactivity in cattle_Group sample datasheet.xlsx

description: Group sample datasheet
DOI: 10.6084/m9.figshare.10264931.v3
title: Inactivity in cattle_Individual duration datasheet

description: Individual duration datasheet
DOI: 10.6084/m9.figshare.10264943.v4
title: Inactivity in cattle_Individual sample datasheet.xlsx

description: Individual sample datasheet
DOI: 10.6084/m9.figshare.10264943.v3
title: Inactivity in cattle_Individual sample datasheet.xlsx

description: Individual sample datasheet
DOI: 10.6084/m9.figshare.10264832
title: Transcriptome profiling of abiotic responses to heat, cold, salt, and osmotic stress of Capsicum annuum L.

description: Additional files generated upon qualification and validation of pepper transcriptome under abiotic stresses Statistical summary of RNA-seq for each sample.xlsx --- Detailed pepper RNA-seq information used in this study DEG result for each stress.zip --- DEG information from four abiotic stresses Normalized TMM.zip --- Expression profiling of TMM normalized data from four abiotic stresses GO enrichment analysis result.zip --- Results of GO enrichment analysis from four abiotic stresses Programs and code information.docx --- Programs and codes used in the RNA-seq data processing‬<br>
DOI: 10.6084/m9.figshare.10264925.v5
title: Inactivity in cattle_Group sample datasheet.xlsx

description: Group sample datasheet
DOI: 10.6084/m9.figshare.10264925.v4
title: Inactivity in cattle_Group sample datasheet.xlsx

description: Group sample datasheet
DOI: 10.6084/m9.figshare.10264832.v1
title: Additional files generated upon qualification and validation of pepper transcriptome under abiotic stresses

description: Additional files generated upon qualification and validation of pepper transcriptome under abiotic stresses<br><br>1) Data_S1.Statistical summary of RNA-seq for each sample.xlsx <br>2) Data_S2.DEG result for each stress.zip --- DEG information from four abiotic stresses<br>3) Data_S3.Normalized TMM.zip --- Expression profiling of TMM normalized data from four abiotic stresses <br>4) Data_S4.GO enrichment analysis result.zip --- Results of GO enrichment analysis from four abiotic stresses<br>5) DATA_S5.Programs and code information.docx<br>‬<br>
DOI: 10.6084/m9.figshare.10264832.v2
title: Transcriptome profiling of abiotic responses to heat, cold, salt, and osmotic stress of Capsicum annuum L.

description: Additional files generated upon qualification and validation of pepper transcriptome under abiotic stresses<br><br>1) Data_S1.Statistical summary of RNA-seq for each sample.xlsx <br>2) Data_S2.DEG result for each stress.zip --- DEG information from four abiotic stresses<br>3) Data_S3.Normalized TMM.zip --- Expression profiling of TMM normalized data from four abiotic stresses <br>4) Data_S4.GO enrichment analysis result.zip --- Results of GO enrichment analysis from four abiotic stresses<br>5) DATA_S5.Programs and code information.docx<br>‬<br>
DOI: 10.6084/m9.figshare.10264805
title: Raw Data: Production and characteristics of fish protein hydrolysate from parrotfish (Chlorurus sordidus) head

description: The data for Production and characteristics of fish protein hydrolysate from parrotfish (Chlorurus sordidus) head