cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.10438229
title: Differential effects of the methylenetetrahydrofolate reductase polymorphisms (C677T and A1298C) on hematological malignancies among Latinos: a meta-analysis

description: Abstract Our objective was to determine the association between the methylenetetrahydrofolate reductase polymorphisms (C677T and A1298C) and the risk of developing acute lymphoblastic leukemia (ALL), chronic myeloid leukemia (CML), acute myeloid leukemia (AML), and multiple myelomas (MM) in Latinos. PubMed, SCOPUS, EBSCO, LILACS, and other Latin-specific databases were searched for case-control studies that investigated the association between these polymorphisms and hematologic malignancies until November 2017. Genotype distributions were extracted and either fixed-effects or random-effects models were used to calculate the pooled crude odds ratios (ORs) for the heterozygous, homozygous, dominant, recessive, and allelic genetic models. No publication bias was detected by the Begg-Mazumdar’s test and Egger’s test. From 290 publications, we identified 15 studies on the C677T polymorphism and 13 studies on the A1298C polymorphism. We observed a significant decrease in risk for the C677T polymorphism (OR range=0.54-0.75, p&lt;0.01) and a significant increase in risk for the A1298C polymorphism (OR range=1.28-2.52, p&lt;0.05) in developing ALL for all genetic models. No associations were determined for CML, AML, or MM for either polymorphism. This meta-analysis demonstrated that the A1298C polymorphism was associated with an increased risk of developing ALL, whereas the C677T polymorphism was associated with a decreased risk (protective factor) in the Latino population.
DOI: 10.6084/m9.figshare.10438238.v1
title: Artificial Intelligence in Cardiology: Concepts, Tools and Challenges - “The Horse is the One Who Runs, You Must Be the Jockey”

description: Abstract The recent advances at hardware level and the increasing requirement of personalization of care associated with the urgent needs of value creation for the patients has helped Artificial Intelligence (AI) to promote a significant paradigm shift in the most diverse areas of medical knowledge, particularly in Cardiology, for its ability to support decision-making and improve diagnostic and prognostic performance. In this context, the present work does a non-systematic review of the main papers published on AI in Cardiology, focusing on its main applications, potential impacts and challenges.
DOI: 10.6084/m9.figshare.10438223
title: Changes in mineral nutrition during fruit growth and development of ‘Seike’ and ‘Newhall’ navel orange as a guide for fertilization

description: Abstract Changes in the accumulation patterns of mineral nutrients at different development stages of fruit reflect the requirements of citrus trees for different nutrients, and this information provides an essential reference for rational fertilization. In this study, changes in the contents of 11 nutrients in the whole fruit, fruit pulp, and peel were studied during the whole developmental period of the fruit of ‘Seike’ and ‘Newhall’ navel oranges. We found that the two navel orange cultivars showed very similar changes in nutrients. Specifically, the N, P, Mg, S, Mn, and Zn contents were high in the young fruit stage (April), the K and Fe contents were high in the fruit expansion stage (July and August), and the Ca content was high in the fruit maturation stage (October). As the fruit developed, the N, P, Mg, S, Zn, and B contents decreased to the lowest levels at fruit maturity in November. In addition, the contents of N, P, K, Fe, Zn, and Cu were ranked as fruit pulp &gt; whole fruit &gt; peel, while Ca, Mn, and B contents were ranked as fruit peel &gt; whole fruit &gt; fruit pulp. N, P, K, and Mg accumulated in the fruit in June and July, in contrast to the June to September period for the micro-elements. During these accumulation periods, it is recommended that suitable fertilizers be applied in a timely manner.
DOI: 10.6084/m9.figshare.10438226
title: COMPARATIVE RESULTS BETWEEN OPEN AND MINIMALLY INVASIVE FUSION IN LUMBAR DEGENERATIVE DISEASE

description: ABSTRACT Objective: Lumbar spine fusion is indicated in patients who are refractory to traditional treatment for degenerative disc disease. The aim of this study was to compare the perioperative and postoperative results of conventional open surgery versus minimally invasive surgery (MIS) in posterior 360° lumbar fusion with pedicle screw instrumentation. Methods: A total of 25 patients underwent MIS and 40 underwent open surgery between 2015 and 2017. Perioperative variables and lumbar and radicular pain values were compared using a visual analogue scale (VAS) and the Oswestry disability index (ODI) until 12 months after surgery. Results: The MIS cohort presented less blood loss (140 vs 345 ml; p=0.001), shorter hospital stay (1.1 vs 2.2 days; p=0.001), longer operative time (113 vs 94 minutes; p=0.001) and greater X-ray exposure (80 vs 6 seconds; p=0.001), compared to the open surgery group. The MIS cohort showed better results in the ODI and lumbar VAS scores. No significant differences were observed in radicular VAS. Conclusion: MIS surgery showed advantages over the open surgery technique; however, the learning curve should be improved in order to reduce operative time. Level of Evidence III; Retrospective descriptive observational study.
DOI: 10.6084/m9.figshare.10438232.v1
title: Upregulation of intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 in renal tissue in severe dengue in humans: Effects on endothelial activation/dysfunction

description: Abstract INTRODUCTION: Dengue is an important mosquito-borne disease in tropical and subtropical regions. Adhesion molecules have not been systematically characterized in the renal tissue of patients with severe dengue (SD). The objective of this study was to detect viral antigens in samples from patients that evolved with SD, correlating with the expression of ICAM-1, VCAM-1, VE-cadherin, and E-selectin to contribute to a better understanding of the pathophysiology of SD. METHODS: Kidney specimens from patients with SD were selected according to clinical and laboratorial data and submitted to histological and immunohistochemistry analysis. A semiquantitative evaluation was performed considering positive immunostaining in 20 glomeruli. RESULTS: Viral antigens were mainly detected in distal tubules. The intense immunostaining of VCAM-1 and ICAM-1 was observed. The expression of E-selectin was discrete, and VE-cadherin expression varied from mild to moderate. VCAM-1 was slightly intense in the glomerular capsule; the expression of ICAM-1 was diffuse. E-selectin was diffuse, and VE-cadherin varied from mild to moderate. The most frequent histological findings were glomerular congestion, mild glomerulitis, acute renal injury, and glomerular atrophy. CONCLUSIONS: The results appear to demonstrate an imbalance between vascular endothelial permeability regulating events in renal lesions in SD. The increase in the expression of ICAM-1 and VCAM-1 is an in-situ indicator of higher permeability with a consequent influx of cells favoring the inflammation of the endothelium. These molecules are important in the pathophysiology of the disease and provide the possibility of developing new markers for the evaluation, clinical follow-up, and therapeutic response of patients with SD.
DOI: 10.6084/m9.figshare.10438229.v1
title: Differential effects of the methylenetetrahydrofolate reductase polymorphisms (C677T and A1298C) on hematological malignancies among Latinos: a meta-analysis

description: Abstract Our objective was to determine the association between the methylenetetrahydrofolate reductase polymorphisms (C677T and A1298C) and the risk of developing acute lymphoblastic leukemia (ALL), chronic myeloid leukemia (CML), acute myeloid leukemia (AML), and multiple myelomas (MM) in Latinos. PubMed, SCOPUS, EBSCO, LILACS, and other Latin-specific databases were searched for case-control studies that investigated the association between these polymorphisms and hematologic malignancies until November 2017. Genotype distributions were extracted and either fixed-effects or random-effects models were used to calculate the pooled crude odds ratios (ORs) for the heterozygous, homozygous, dominant, recessive, and allelic genetic models. No publication bias was detected by the Begg-Mazumdar’s test and Egger’s test. From 290 publications, we identified 15 studies on the C677T polymorphism and 13 studies on the A1298C polymorphism. We observed a significant decrease in risk for the C677T polymorphism (OR range=0.54-0.75, p&lt;0.01) and a significant increase in risk for the A1298C polymorphism (OR range=1.28-2.52, p&lt;0.05) in developing ALL for all genetic models. No associations were determined for CML, AML, or MM for either polymorphism. This meta-analysis demonstrated that the A1298C polymorphism was associated with an increased risk of developing ALL, whereas the C677T polymorphism was associated with a decreased risk (protective factor) in the Latino population.
DOI: 10.6084/m9.figshare.10438214
title: Gene pool sharing and genetic bottleneck effects in subpopulations of Eschweilera ovata (Cambess.) Mart. ex Miers (Lecythidaceae) in the Atlantic Forest of southern Bahia, Brazil

description: Abstract Forest loss and fragmentation are the main threats to the maintenance of the Atlantic Forest, an important global biodiversity hotspot. Because of the current critical level of deforestation, ecological corridors are needed to facilitate species dispersion and gene flow among fragments. This study was conducted to investigate the genetic variability and gene pool sharing of Eschweilera ovata in five forest remnants in southern Bahia, Brazil using nuclear simple sequence repeat (nSSR) and plastid simple sequence repeat (cpSSR) microsatellite markers. cpSSR marker analysis revealed the domains of four haplotypes, showing that 80% of the individuals had only four maternal origins, reflecting a founder effect and/or genetic bottleneck. The results of cpSSR and nSSR analyses indicated moderate genetic diversity, particularly in conservation units with full protection, which showed the best parameters of all areas evaluated. Another indication of the susceptibility of these populations to forest loss and fragmentation was the strong genetic bottleneck observed. In contrast, genetic structure analyses (FST and discriminant analysis of principal components) revealed gene pool sharing between the subpopulations, which may reflect the historical gene flow that occurred before forest fragmentation.
DOI: 10.6084/m9.figshare.10438223.v1
title: Changes in mineral nutrition during fruit growth and development of ‘Seike’ and ‘Newhall’ navel orange as a guide for fertilization

description: Abstract Changes in the accumulation patterns of mineral nutrients at different development stages of fruit reflect the requirements of citrus trees for different nutrients, and this information provides an essential reference for rational fertilization. In this study, changes in the contents of 11 nutrients in the whole fruit, fruit pulp, and peel were studied during the whole developmental period of the fruit of ‘Seike’ and ‘Newhall’ navel oranges. We found that the two navel orange cultivars showed very similar changes in nutrients. Specifically, the N, P, Mg, S, Mn, and Zn contents were high in the young fruit stage (April), the K and Fe contents were high in the fruit expansion stage (July and August), and the Ca content was high in the fruit maturation stage (October). As the fruit developed, the N, P, Mg, S, Zn, and B contents decreased to the lowest levels at fruit maturity in November. In addition, the contents of N, P, K, Fe, Zn, and Cu were ranked as fruit pulp &gt; whole fruit &gt; peel, while Ca, Mn, and B contents were ranked as fruit peel &gt; whole fruit &gt; fruit pulp. N, P, K, and Mg accumulated in the fruit in June and July, in contrast to the June to September period for the micro-elements. During these accumulation periods, it is recommended that suitable fertilizers be applied in a timely manner.
DOI: 10.6084/m9.figshare.10438226.v1
title: COMPARATIVE RESULTS BETWEEN OPEN AND MINIMALLY INVASIVE FUSION IN LUMBAR DEGENERATIVE DISEASE

description: ABSTRACT Objective: Lumbar spine fusion is indicated in patients who are refractory to traditional treatment for degenerative disc disease. The aim of this study was to compare the perioperative and postoperative results of conventional open surgery versus minimally invasive surgery (MIS) in posterior 360° lumbar fusion with pedicle screw instrumentation. Methods: A total of 25 patients underwent MIS and 40 underwent open surgery between 2015 and 2017. Perioperative variables and lumbar and radicular pain values were compared using a visual analogue scale (VAS) and the Oswestry disability index (ODI) until 12 months after surgery. Results: The MIS cohort presented less blood loss (140 vs 345 ml; p=0.001), shorter hospital stay (1.1 vs 2.2 days; p=0.001), longer operative time (113 vs 94 minutes; p=0.001) and greater X-ray exposure (80 vs 6 seconds; p=0.001), compared to the open surgery group. The MIS cohort showed better results in the ODI and lumbar VAS scores. No significant differences were observed in radicular VAS. Conclusion: MIS surgery showed advantages over the open surgery technique; however, the learning curve should be improved in order to reduce operative time. Level of Evidence III; Retrospective descriptive observational study.
DOI: 10.6084/m9.figshare.10438211
title: Genetic diversity of bushy cashew (Anacardium humile A. St.-Hil.) based on characteristics of fruits

description: Abstract Knowledge of the genetic variability among genotypes of bushy cashew is important to establish strategies for pre-breeding and use in breeding program. The objective of this study was to evaluate the genetic diversity of bushy cashew by means of the evaluation of physical, chemical and physicochemical characteristics of cashew apples and cashew nuts. The work was carried out with cashew nuts and cashew apples collected in the harvest of 2016 of genotypes in the “ex situ” biological collection of Anacardium humile A. St.-Hil. in the area of genetic resources of the Universidade Federal de Goiás - Regional Jataí. The results were submitted to descriptive analysis and multivariate analysis, estimating the mean Euclidean distance obtained from the fruiting attributes analyzed. The measure of similarity and custering of the provenances was done by the optimization algorithm of Tocher and dendrograma UPGMA. There was a coincidence of clusters, which confirms the distribution of genetic diversity of the genotypes in the germplasm bank of Anacardium humileA. St.-Hil. evaluated. The results obtained can be used for the selection of individuals of the species in future works of breeding and conservation of the specie.
DOI: 10.6084/m9.figshare.10438214.v1
title: Gene pool sharing and genetic bottleneck effects in subpopulations of Eschweilera ovata (Cambess.) Mart. ex Miers (Lecythidaceae) in the Atlantic Forest of southern Bahia, Brazil

description: Abstract Forest loss and fragmentation are the main threats to the maintenance of the Atlantic Forest, an important global biodiversity hotspot. Because of the current critical level of deforestation, ecological corridors are needed to facilitate species dispersion and gene flow among fragments. This study was conducted to investigate the genetic variability and gene pool sharing of Eschweilera ovata in five forest remnants in southern Bahia, Brazil using nuclear simple sequence repeat (nSSR) and plastid simple sequence repeat (cpSSR) microsatellite markers. cpSSR marker analysis revealed the domains of four haplotypes, showing that 80% of the individuals had only four maternal origins, reflecting a founder effect and/or genetic bottleneck. The results of cpSSR and nSSR analyses indicated moderate genetic diversity, particularly in conservation units with full protection, which showed the best parameters of all areas evaluated. Another indication of the susceptibility of these populations to forest loss and fragmentation was the strong genetic bottleneck observed. In contrast, genetic structure analyses (FST and discriminant analysis of principal components) revealed gene pool sharing between the subpopulations, which may reflect the historical gene flow that occurred before forest fragmentation.
DOI: 10.6084/m9.figshare.10438202
title: Natural convection drying kinetics of ‘Prata’ and ‘D’água’ banana cultivars (Musa ssp) by nonlinear regression models

description: Abstract Banana is among fruits most planted in tropical countries and belongs to the fruit group most consumed in the world; however, banana needs proper conservation techniques. The aim of this study was to describe the drying kinetics of ‘Prata’ and ‘D’água’ banana cultivars at temperatures of 40 and 70°C, comparing the Henderson, STPE, Lewis, Page and Fick regression models, estimating the Absolute Drying Rate (ADR). Parameters were estimated with R and SAS Studio softwares, using for comparison and selection models of the R²aj, RSD and corrected Akaike Information Criteria. The Page and Fick models did not adjust, and the others presented good adjustment to data. The Henderson model was the most suitable to describe data of ‘Prata’ banana at both temperatures and ‘D’água’ banana at 70°C and Lewis at 40°C for this cultivar. The drying rate of ‘Prata’ banana at temperatures of 40 and 70°C were 0.00079 g of water/ min and 0.00400 g of water/min respectively and for ‘D’água’ banana, drying rates were 0.00111 g of water/min. and 0.00495 g of water/min., respectively. Using ADR, it was observed that in one third of the drying period, there was 70% of moisture loss at 70°C.
DOI: 10.6084/m9.figshare.10438205
title: Descriptive Anatomy of Hepatic and Portal Veins with Special Reference to Biliary Duct System in Broiler Chickens (Gallus gallus domesticus): A Recent Illustration

description: ABSTRACT Chickens have a great participation in meat and egg production. The anatomical scientific data of poultry is important to support the recent researches either for illustrations in academic studies or clinically in diagnosis and treatment of some poultry nutritional diseases. The current investigation was performed on twenty broiler chickens of both sexes. The chickens were anaesthetized, slaughtered then the venous system was flushed with a normal saline to anatomically investigate the distribution of hepatic portal veins both intra and extrahepatic, as well as the hepatic venous and biliary duct systems. The fowl had two hepatic portal veins draining the gastrointestinal tract with its associated organs as spleen and pancreas. The left hepatic portal vein was small, restricted to a limited portion of left hepatic lobe and had been constituted by five main venous tributaries draining the proventriculus, gizzard and pylorus, while the right hepatic portal vein was the largest, receiving the proventriculosplenic, gastropancreaticoduodenal and common mesenteric veins then piercing the right hepatic lobe to be distributed in both hepatic segments through right and left divisions. The fowl has two hepatic portal veins differed in size and distribution. A characteristic imaginary trapezoid shape was formed by some tributaries draining the caudoventral part of the gizzard. There are three ileocecal veins; cranial, caudal and the ileocecal tributary of the cranial mesenteric vein. The wall of gall bladder and the common hepatoenteric duct was characterized by the presence of well-defined longitudinal folds or striations.
DOI: 10.6084/m9.figshare.10438208
title: The rs10455872-G allele of the LPA gene is associated with high lipoprotein(a) levels and increased aortic valve calcium in a Mexican adult population

description: Abstract Polymorphisms in the LPA gene have been associated with aortic valve calcification (AVC). There are wide differences in the allelic frequencies, Lp(a) levels, and the association with AVC among ethnic groups. The aim of this study was to determine the association of the LPA gene polymorphisms with Lp(a) levels and risk of developing AVC, in Mexican-Mestizos population. Six LPA polymorphisms (rs10455872, rs7765803, rs6907156, rs1321195, rs12212807 and rs6919346) were genotyped by TaqMan assays in 1,265 individuals without premature coronary artery disease. The presence of AVC was determined by computed tomography. The association of the LPA polymorphisms with AVC, Lp(a), and other cardiovascular risk factors (CVRF) was evaluated using logistic regression analysis. Compared to AA genotype, subjects with AG+GG genotypes had high prevalence of Lp(a) ≥ 30 mg/dL (7.1% vs. 23.7%, p&lt;0.001) and AVC (19.0% vs. 29.4%, p=0.007). In a model adjusted for several CVRF, the LPA rs10455872-G allele was associated with high Lp(a) levels and AVC. Carriers of G allele had a high risk of Lp(a) ≥ 30 mg/dL (OR= 3.86, CI 95%: 2.2 - 6.7, p=0.001) and AVC (OR= 2.54, CI 95%: 1.56 - 4.14, p=0.001), independently of other CVRF. In this population, carriers of rs10455872-G allele had 3.86 and 2.54 higher risk of Lp(a) ≥ 30 mg/dL or presence of AVC, respectively.
DOI: 10.6084/m9.figshare.10438211.v1
title: Genetic diversity of bushy cashew (Anacardium humile A. St.-Hil.) based on characteristics of fruits

description: Abstract Knowledge of the genetic variability among genotypes of bushy cashew is important to establish strategies for pre-breeding and use in breeding program. The objective of this study was to evaluate the genetic diversity of bushy cashew by means of the evaluation of physical, chemical and physicochemical characteristics of cashew apples and cashew nuts. The work was carried out with cashew nuts and cashew apples collected in the harvest of 2016 of genotypes in the “ex situ” biological collection of Anacardium humile A. St.-Hil. in the area of genetic resources of the Universidade Federal de Goiás - Regional Jataí. The results were submitted to descriptive analysis and multivariate analysis, estimating the mean Euclidean distance obtained from the fruiting attributes analyzed. The measure of similarity and custering of the provenances was done by the optimization algorithm of Tocher and dendrograma UPGMA. There was a coincidence of clusters, which confirms the distribution of genetic diversity of the genotypes in the germplasm bank of Anacardium humileA. St.-Hil. evaluated. The results obtained can be used for the selection of individuals of the species in future works of breeding and conservation of the specie.