cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.16494410
title: Genetics of Parkinson’s disease in Brazil: a systematic review of monogenic forms

description: ABSTRACT Background: Increasing numbers of mutations causing monogenic forms of Parkinson's disease (PD) have been described, mostly among patients in Europe and North America. Since genetic architecture varies between different populations, studying the specific genetic profile of Brazilian patients is essential for improving genetic counseling and for selecting patients for clinical trials. Objective: We conducted a systematic review to identify genetic studies on Brazilian patients and to set a background for future studies on monogenic forms of PD in Brazil. Methods: We searched MEDLINE, EMBASE and Web of Science from inception to December 2019 using terms for "Parkinson's disease", "genetics" and "Brazil". Two independent reviewers extracted the data. For the genes LRRK2 and PRKN, the estimated prevalence was calculated for each study, and a meta-analysis was performed. Results: A total of 32 studies were included, comprising 94 Brazilian patients with PD with a causative mutation, identified from among 2,872 screened patients (3.2%). PRKN mutations were causative of PD in 48 patients out of 576 (8.3%). LRRK2 mutations were identified in 40 out of 1,556 patients (2.5%), and p.G2019S was the most common mutation (2.2%). Conclusions: PRKN is the most common autosomal recessive cause of PD, and LRRK2 is the most common autosomal dominant form. We observed that there was a lack of robust epidemiological studies on PD genetics in Brazil and, especially, that the diversity of Brazil’s population had not been considered.
DOI: 10.6084/m9.figshare.16494410.v1
title: Genetics of Parkinson’s disease in Brazil: a systematic review of monogenic forms

description: ABSTRACT Background: Increasing numbers of mutations causing monogenic forms of Parkinson's disease (PD) have been described, mostly among patients in Europe and North America. Since genetic architecture varies between different populations, studying the specific genetic profile of Brazilian patients is essential for improving genetic counseling and for selecting patients for clinical trials. Objective: We conducted a systematic review to identify genetic studies on Brazilian patients and to set a background for future studies on monogenic forms of PD in Brazil. Methods: We searched MEDLINE, EMBASE and Web of Science from inception to December 2019 using terms for "Parkinson's disease", "genetics" and "Brazil". Two independent reviewers extracted the data. For the genes LRRK2 and PRKN, the estimated prevalence was calculated for each study, and a meta-analysis was performed. Results: A total of 32 studies were included, comprising 94 Brazilian patients with PD with a causative mutation, identified from among 2,872 screened patients (3.2%). PRKN mutations were causative of PD in 48 patients out of 576 (8.3%). LRRK2 mutations were identified in 40 out of 1,556 patients (2.5%), and p.G2019S was the most common mutation (2.2%). Conclusions: PRKN is the most common autosomal recessive cause of PD, and LRRK2 is the most common autosomal dominant form. We observed that there was a lack of robust epidemiological studies on PD genetics in Brazil and, especially, that the diversity of Brazil’s population had not been considered.
DOI: 10.5281/zenodo.4181930
title: Topics in Research on International Relations as Clusters of Citation Links

description: Data, scripts, and results of a memetic topic clustering of citation links in papers published 2011-2015 in the specialty of political science that is dealing with international relations Supplementary Information to the paper about "Topics as clusters of citation links to highly cited sources: The case of research on international relation" by Frank Havemann<em> </em>(published 2021 in the OA-journal<em> Quantitative Science Studies</em> 2 (1): 204–223). https://doi.org/10.1162/qss_a_00108
description: Data are described in the file read.me.R and in the paper "Topics as Clusters of Citation Links to Highly Cited Sources: The Case of Research on International Relations" by Frank Havemann. It is available at https://doi.org/10.1162/qss_a_00108 and as an arXiv-preprint: 2007.15254. This work is part of the Global Pathways project (http://t1p.de/globalpathways) sponsored by DFG (grant RI 798/11-1). The raw data were obtained from the Web of Science database produced by Clarivate Analytics. Due to license restrictions, the data cannot be made openly available. To obtain Web of Science data, please contact Clarivate Analytics (https://clarivate.com/ products/web-of-science).
description: {"references": ["Frank Havemann (2020), Topics as Clusters of Citation Links to Highly Cited Sources: The Case of Research on International Relations. Arxiv:2007.15254"]}
DOI: 10.5281/zenodo.3964601
title: Topics in Research on International Relations as Clusters of Citation Links

description: Data, scripts, and results of a memetic topic clustering of citation links in papers published 2011-2015 in the specialty of political science that is dealing with international relations Supplementary Information to the paper about "Topics as clusters of citation links to highly cited sources: The case of research on international relation" by Frank Havemann<em> </em>(published 2021 in the OA-journal<em> Quantitative Science Studies</em> 2 (1): 204–223). https://doi.org/10.1162/qss_a_00108
description: Data are described in the file read.me.R and in the paper "Topics as Clusters of Citation Links to Highly Cited Sources: The Case of Research on International Relations" by Frank Havemann. It is available at https://doi.org/10.1162/qss_a_00108 and as an arXiv-preprint: 2007.15254. This work is part of the Global Pathways project (http://t1p.de/globalpathways) sponsored by DFG (grant RI 798/11-1). The raw data were obtained from the Web of Science database produced by Clarivate Analytics. Due to license restrictions, the data cannot be made openly available. To obtain Web of Science data, please contact Clarivate Analytics (https://clarivate.com/ products/web-of-science).
description: {"references": ["Frank Havemann (2020), Topics as Clusters of Citation Links to Highly Cited Sources: The Case of Research on International Relations. Arxiv:2007.15254"]}
DOI: 10.6084/m9.figshare.16494530
title: Use of non-invasive stimulation in movement disorders: a critical review

description: Abstract Background: Noninvasive stimulation has been widely used in the past 30 years to study and treat a large number of neurological diseases, including movement disorders. Objective: In this critical review, we illustrate the rationale for use of these techniques in movement disorders and summarize the best medical evidence based on the main clinical trials performed to date. Methods: A nationally representative group of experts performed a comprehensive review of the literature in order to analyze the key clinical decision-making factors driving transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS) in movement disorders. Classes of evidence and recommendations were described for each disease. Results: Despite unavoidable heterogeneities and low effect size, TMS is likely to be effective for treating motor symptoms and depression in Parkinson’s disease (PD). The efficacy in other movement disorders is unclear. TMS is possibly effective for focal hand dystonia, essential tremor and cerebellar ataxia. Additionally, it is likely to be ineffective in reducing tics in Tourette syndrome. Lastly, tDCS is likely to be effective in improving gait in PD. Conclusions: There is encouraging evidence for the use of noninvasive stimulation on a subset of symptoms in selected movement disorders, although the means to optimize protocols for improving positive outcomes in routine clinical practice remain undetermined. Similarly, the best stimulation paradigms and responder profile need to be investigated in large clinical trials with established therapeutic and assessment paradigms that could also allow genuine long-term benefits to be determined.
DOI: 10.6084/m9.figshare.16494530.v1
title: Use of non-invasive stimulation in movement disorders: a critical review

description: Abstract Background: Noninvasive stimulation has been widely used in the past 30 years to study and treat a large number of neurological diseases, including movement disorders. Objective: In this critical review, we illustrate the rationale for use of these techniques in movement disorders and summarize the best medical evidence based on the main clinical trials performed to date. Methods: A nationally representative group of experts performed a comprehensive review of the literature in order to analyze the key clinical decision-making factors driving transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS) in movement disorders. Classes of evidence and recommendations were described for each disease. Results: Despite unavoidable heterogeneities and low effect size, TMS is likely to be effective for treating motor symptoms and depression in Parkinson’s disease (PD). The efficacy in other movement disorders is unclear. TMS is possibly effective for focal hand dystonia, essential tremor and cerebellar ataxia. Additionally, it is likely to be ineffective in reducing tics in Tourette syndrome. Lastly, tDCS is likely to be effective in improving gait in PD. Conclusions: There is encouraging evidence for the use of noninvasive stimulation on a subset of symptoms in selected movement disorders, although the means to optimize protocols for improving positive outcomes in routine clinical practice remain undetermined. Similarly, the best stimulation paradigms and responder profile need to be investigated in large clinical trials with established therapeutic and assessment paradigms that could also allow genuine long-term benefits to be determined.
DOI: 10.6084/m9.figshare.16494601
title: Comparison of two systems for the video head impulse test (vHIT) for the lateral semicircular canal: description of results from normal and pathological subjects

description: ABSTRACT Background: The video head impulse test (vHIT) is a recent technique for functional evaluation of semicircular canals (SSCs). The vHIT examines eye movements at high frequencies of stimulation and provides an objective assessment of the functioning of the high-frequency domain of the vestibular system. Objective: To describe the results from vHIT performed using two systems. Methods: All subjects were evaluated through an audiological and otoneurological battery of tests and were diagnosed as normal or abnormal by an otorhinolaryngologist. The results from two systems: 1. ICS Impulse (Otometrics/Natus, Denmark) and 2. EyeSeeCam (InterAcoustics, Denmark) were recorded. The same operator delivered every impulse to every subject. The head impulses were performed while the operator was standing behind the subject, using both hands on the top of the subject’s head, well away from the goggles strap and forehead skin. Two calibrations were completed in each system, prior to beginning the test. Results: Test parameters were recorded through both systems for healthy subjects with no history or complaint of any vestibular disorder (N = 12; M/F = 5/7; age 35.1 ± 13.5 y) and for pathological subjects with a diagnosis of unilateral or bilateral vestibular disorder (N = 15; M/F = 7/8; age 53.4 ± 16.7 y). Conclusions: The vHIT is an important tool for otoneurological complementary evaluation. Both systems are reliable for vestibular disorders. The EyeSeeCam seems to reject fewer data and provides more information to include in diagnostics. Because of the small sample, there is a need for further in-depth comparison of both systems.
DOI: 10.6084/m9.figshare.16494601.v1
title: Comparison of two systems for the video head impulse test (vHIT) for the lateral semicircular canal: description of results from normal and pathological subjects

description: ABSTRACT Background: The video head impulse test (vHIT) is a recent technique for functional evaluation of semicircular canals (SSCs). The vHIT examines eye movements at high frequencies of stimulation and provides an objective assessment of the functioning of the high-frequency domain of the vestibular system. Objective: To describe the results from vHIT performed using two systems. Methods: All subjects were evaluated through an audiological and otoneurological battery of tests and were diagnosed as normal or abnormal by an otorhinolaryngologist. The results from two systems: 1. ICS Impulse (Otometrics/Natus, Denmark) and 2. EyeSeeCam (InterAcoustics, Denmark) were recorded. The same operator delivered every impulse to every subject. The head impulses were performed while the operator was standing behind the subject, using both hands on the top of the subject’s head, well away from the goggles strap and forehead skin. Two calibrations were completed in each system, prior to beginning the test. Results: Test parameters were recorded through both systems for healthy subjects with no history or complaint of any vestibular disorder (N = 12; M/F = 5/7; age 35.1 ± 13.5 y) and for pathological subjects with a diagnosis of unilateral or bilateral vestibular disorder (N = 15; M/F = 7/8; age 53.4 ± 16.7 y). Conclusions: The vHIT is an important tool for otoneurological complementary evaluation. Both systems are reliable for vestibular disorders. The EyeSeeCam seems to reject fewer data and provides more information to include in diagnostics. Because of the small sample, there is a need for further in-depth comparison of both systems.
DOI: 10.6084/m9.figshare.16494670
title: Spectrum of ocular manifestations and visual outcomes of neurosyphilis among 53 patients

description: ABSTRACT Background: In the era of the re-emergence of syphilis, ocular syphilis has gained attention because its prevalence has increased and it can cause blindness and disability. Objectives: To investigate the clinical presentation and prognosis of ocular syphilis. Methods: Prospective study on 53 patients (90 eyes) with ocular syphilis diagnosed at the Santa Casa of Belo Horizonte, Brazil. The diagnosis was based on clinical manifestations of the disease and on serological markers (positive serum treponemal and non-treponemal tests or two positive treponemal tests). Results: Thirty-five eyes (66%) were from men and the mean age was 45.3 ± 12.0 years. HIV coinfection was confirmed in 10 patients (18.9%). Forty-four (84.9%) had VDRL titers ≥ 1:32. Bilateral ocular involvement occurred in 68%. Optic neuritis was diagnosed in 51.7% of the eyes and uveitis in 48.2%. Regarding visual acuity, the median baseline logarithm of the minimum angle of resolution (logMAR) was 1 (20/200 Snellen), while after antibiotic therapy, the median was 0.2 (20/30 Snellen). Poor visual acuity after treatment, defined as the best-corrected visual acuity (BCVA; logMAR 1; 20/200 Snellen) or worse, was associated with severe BCVA at presentation (below logMAR 1.3; 20/400 Snellen) (p = 0.001) and age over 50 years (p = 0.001). Conclusions: This study confirms the wide spectrum of clinical manifestations of ocular syphilis. The most frequent form was optic neuritis, an important differential diagnosis from other causes of inflammatory neuritis. Early diagnosis is essential, given that this is a treatable condition with excellent visual recovery in most cases.
DOI: 10.6084/m9.figshare.16494670.v1
title: Spectrum of ocular manifestations and visual outcomes of neurosyphilis among 53 patients

description: ABSTRACT Background: In the era of the re-emergence of syphilis, ocular syphilis has gained attention because its prevalence has increased and it can cause blindness and disability. Objectives: To investigate the clinical presentation and prognosis of ocular syphilis. Methods: Prospective study on 53 patients (90 eyes) with ocular syphilis diagnosed at the Santa Casa of Belo Horizonte, Brazil. The diagnosis was based on clinical manifestations of the disease and on serological markers (positive serum treponemal and non-treponemal tests or two positive treponemal tests). Results: Thirty-five eyes (66%) were from men and the mean age was 45.3 ± 12.0 years. HIV coinfection was confirmed in 10 patients (18.9%). Forty-four (84.9%) had VDRL titers ≥ 1:32. Bilateral ocular involvement occurred in 68%. Optic neuritis was diagnosed in 51.7% of the eyes and uveitis in 48.2%. Regarding visual acuity, the median baseline logarithm of the minimum angle of resolution (logMAR) was 1 (20/200 Snellen), while after antibiotic therapy, the median was 0.2 (20/30 Snellen). Poor visual acuity after treatment, defined as the best-corrected visual acuity (BCVA; logMAR 1; 20/200 Snellen) or worse, was associated with severe BCVA at presentation (below logMAR 1.3; 20/400 Snellen) (p = 0.001) and age over 50 years (p = 0.001). Conclusions: This study confirms the wide spectrum of clinical manifestations of ocular syphilis. The most frequent form was optic neuritis, an important differential diagnosis from other causes of inflammatory neuritis. Early diagnosis is essential, given that this is a treatable condition with excellent visual recovery in most cases.
DOI: 10.6084/m9.figshare.16494698.v1
title: Juliano Moreira: the black Brazilian who greatly influenced the modern school of Neurology in Brazil

description: Abstract Juliano Moreira was a black Brazilian physician, well recognized for his role in the foundation of scientific psychiatry in Brazil; however, little is known about his influences on modern Neurology. Our aim is to highlight Moreira’s importance in the field of Neurology and his role in the development of scientific and medical societies in Brazil. We describe his contributions from his doctoral thesis in 1891 to his 27-year tenure as the director of the National Hospice for the Insane. We also review Moreira’s role in the foundation of societies including the Brazilian Academy of Sciences and the first Brazilian journal dedicated to Neuropsychiatry, concluding that Moreira was one of the most important influential figures for the development of Neurology in Brazil. In addition to his influences on various medical fields, Moreira distinguished himself as an impactful citizen who fought against racist and xenophobic medical theories of his time.
DOI: 10.6084/m9.figshare.16494698
title: Juliano Moreira: the black Brazilian who greatly influenced the modern school of Neurology in Brazil

description: Abstract Juliano Moreira was a black Brazilian physician, well recognized for his role in the foundation of scientific psychiatry in Brazil; however, little is known about his influences on modern Neurology. Our aim is to highlight Moreira’s importance in the field of Neurology and his role in the development of scientific and medical societies in Brazil. We describe his contributions from his doctoral thesis in 1891 to his 27-year tenure as the director of the National Hospice for the Insane. We also review Moreira’s role in the foundation of societies including the Brazilian Academy of Sciences and the first Brazilian journal dedicated to Neuropsychiatry, concluding that Moreira was one of the most important influential figures for the development of Neurology in Brazil. In addition to his influences on various medical fields, Moreira distinguished himself as an impactful citizen who fought against racist and xenophobic medical theories of his time.
DOI: 10.6084/m9.figshare.16494773
title: Telemedicine use among neurologists before and during COVID-19 pandemic

description: ABSTRACT Background: After the public health emergency due to COVID-19 was declared in Brazil, the federal government temporarily regulated and authorized the use of telemedicine services for patient consultation, monitoring, and diagnosis. For more than a decade, neurologists have recognized the benefits of telemedicine in the acute management of stroke patients. However, as the use of telemedicine was restricted until the COVID-19 pandemic, the view of Brazilian neurologists about telemedicine is unknown. Methods: All neurologists registered at the Brazilian Academy of Neurology were invited by e-mail to participate in a survey about personal perceptions on telemedicine use. Results: One hundred sixty-two neurologists from all regions of Brazil answered the online questionnaire. The survey showed that 18.5% of participants worked with telemedicine before the pandemic, while 63.6% reported working with telemedicine during the pandemic. The main telemedicine modalities used during the pandemic were teleorientation and teleconsultation. Discussion: According to our data, the COVID-19 pandemic deeply influenced the behavior of Brazilian neurologists, who developed a more favorable view about telemedicine and actively searched for information about telemedicine. As there is a need for more training in this area in Brazil, universities and medical societies must strive to improve telemedicine education. Expanding the use of high-quality teleneurology can contribute to a better care for patients with neurological diseases in Brazil.
DOI: 10.6084/m9.figshare.16494773.v1
title: Telemedicine use among neurologists before and during COVID-19 pandemic

description: ABSTRACT Background: After the public health emergency due to COVID-19 was declared in Brazil, the federal government temporarily regulated and authorized the use of telemedicine services for patient consultation, monitoring, and diagnosis. For more than a decade, neurologists have recognized the benefits of telemedicine in the acute management of stroke patients. However, as the use of telemedicine was restricted until the COVID-19 pandemic, the view of Brazilian neurologists about telemedicine is unknown. Methods: All neurologists registered at the Brazilian Academy of Neurology were invited by e-mail to participate in a survey about personal perceptions on telemedicine use. Results: One hundred sixty-two neurologists from all regions of Brazil answered the online questionnaire. The survey showed that 18.5% of participants worked with telemedicine before the pandemic, while 63.6% reported working with telemedicine during the pandemic. The main telemedicine modalities used during the pandemic were teleorientation and teleconsultation. Discussion: According to our data, the COVID-19 pandemic deeply influenced the behavior of Brazilian neurologists, who developed a more favorable view about telemedicine and actively searched for information about telemedicine. As there is a need for more training in this area in Brazil, universities and medical societies must strive to improve telemedicine education. Expanding the use of high-quality teleneurology can contribute to a better care for patients with neurological diseases in Brazil.