cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.19121957.v1
title: The impact of tobacco smoking on survival of patients with oral squamous cell carcinoma: a population-based retrospective study

description: This article aims to evaluate the impact of smoking status, accumulated tobacco exposure (ATE), and smoking cessation on overall- and disease-free survival (OS and DFS) of patients with oral squamous cell carcinoma (OSCC). Patients with primary OSCC treated with curative intent between 2000 and 2019 in Copenhagen were included (<i>n</i> = 1808). Kaplan–Meier curves and multivariable Cox regression analyses were performed to compare the survival of patients with different smoking history. Interactions between ATE and (A) tumor subsite and (B) excessive alcohol consumption (EAC) on the survival were evaluated using multivariable Cox regression analyses with interaction terms. We included 1717 patients with known smoking status (62.8% males, median age: 64 years (IQR: 57–71 years)), who had a 5-year OS of 53.7% (95%CI: 49.8%–57.9%). Based on fully adjusted multivariable Cox regression analyses, significantly elevated hazard ratios (HRs) for OS and DFS were identified for current, but not former smokers, compared to never-smokers. An approximately linear relationship between continuous ATE and survival estimates was identified. ATE analyzed as a categorical variable showed significantly elevated HRs for OS of patients with all categories (0&lt;<i>x</i> ≤ 30, 30&lt;<i>x</i> ≤ 60, and &gt;60 PYs), however only for DFS of patients with &gt;60 PYs, compared to 0 PYs. Furthermore, an unfavorable long-term prognosis was evident after &gt;3.5 (OS) and &gt;2.5 (DFS) years from diagnosis for patients who continued smoking compared to patients with smoking cessation at diagnosis. The survival estimates of patients with different tumor subsite and alcohol consumption differed with increasing ATE. Tobacco smoking (assessed as smoking status and ATE) was associated with inferior survival (OS and DFS) among patients with OSCC. Unfavorable long-term prognosis was significant for patients who continued smoking compared to patients with smoking cessation at diagnosis. The impact of ATE on survival of patients with OSCC may depend on the tumor subsite and/or alcohol consumption.
DOI: 10.6084/m9.figshare.19221361
title: Geriatric assessment and treatment outcomes in a Dutch cohort of older patients with potentially curable esophageal cancer

description: Patients with potentially curable esophageal cancer can be treated with neo-adjuvant chemoradiotherapy followed by surgery or definitive chemoradiotherapy with curative intent. For frail older patients choosing the appropriate oncological treatment can be difficult, and data on geriatric deficits as determinants of treatment outcomes are not yet available. To describe the prevalence of geriatric deficits and to study their association with treatment discontinuation and mortality in older patients with potentially curable esophageal cancer. A cohort study was conducted in a Dutch tertiary care hospital including patients aged ≥70 years with primary stage I-IVA esophageal cancer. Geriatric screening and assessment data were collected. Outcomes were treatment discontinuation and one year all-cause mortality. In total, 138 patients with curable esophageal cancer were included. Mean age was 76.1 years (standard deviation 4.7), 54% had clinical stage III and 24% stage IVA disease. Most patients received neo-adjuvant chemoradiotherapy and surgery (41%), 32% definitive chemoradiotherapy and 22% palliative radiotherapy. Overall, one year all-cause mortality was 36%. Geriatric screening and assessment was performed in 94 out of 138 patients, of which 60% was malnourished, 20% dependent in Instrumental Activities of Daily Living (IADL) and 52% was frail. Malnutrition was associated with higher mortality risk (Hazard Ratio, 3.2; 95% Confidence Interval, 1.3–7.7)) independent of age, sex and tumor stage. Seventy-six out of 94 patients were treated with chemoradiotherapy, of which 23% discontinued treatment. Patients with IADL dependency and Charlson Comorbidity Index ≥1 discontinued treatment more often. All-cause mortality within one year was high, irrespective of treatment modality. Treatment discontinuation rate was high, especially in patients treated with definitive chemoradiotherapy. Geriatric assessment associates with outcomes in older patients with esophageal cancer and may inform treatment decisions and optimization in future patients, but more research is needed to establish its predictive value. <b>Trial registration:</b> The study is retrospectively registered at the Netherlands Trial Register (NTR), trial number NL8107. Date of registration: 22-10-2019.
DOI: 10.6084/m9.figshare.19121957
title: The impact of tobacco smoking on survival of patients with oral squamous cell carcinoma: a population-based retrospective study

description: This article aims to evaluate the impact of smoking status, accumulated tobacco exposure (ATE), and smoking cessation on overall- and disease-free survival (OS and DFS) of patients with oral squamous cell carcinoma (OSCC). Patients with primary OSCC treated with curative intent between 2000 and 2019 in Copenhagen were included (<i>n</i> = 1808). Kaplan–Meier curves and multivariable Cox regression analyses were performed to compare the survival of patients with different smoking history. Interactions between ATE and (A) tumor subsite and (B) excessive alcohol consumption (EAC) on the survival were evaluated using multivariable Cox regression analyses with interaction terms. We included 1717 patients with known smoking status (62.8% males, median age: 64 years (IQR: 57–71 years)), who had a 5-year OS of 53.7% (95%CI: 49.8%–57.9%). Based on fully adjusted multivariable Cox regression analyses, significantly elevated hazard ratios (HRs) for OS and DFS were identified for current, but not former smokers, compared to never-smokers. An approximately linear relationship between continuous ATE and survival estimates was identified. ATE analyzed as a categorical variable showed significantly elevated HRs for OS of patients with all categories (0&lt;<i>x</i> ≤ 30, 30&lt;<i>x</i> ≤ 60, and &gt;60 PYs), however only for DFS of patients with &gt;60 PYs, compared to 0 PYs. Furthermore, an unfavorable long-term prognosis was evident after &gt;3.5 (OS) and &gt;2.5 (DFS) years from diagnosis for patients who continued smoking compared to patients with smoking cessation at diagnosis. The survival estimates of patients with different tumor subsite and alcohol consumption differed with increasing ATE. Tobacco smoking (assessed as smoking status and ATE) was associated with inferior survival (OS and DFS) among patients with OSCC. Unfavorable long-term prognosis was significant for patients who continued smoking compared to patients with smoking cessation at diagnosis. The impact of ATE on survival of patients with OSCC may depend on the tumor subsite and/or alcohol consumption.
DOI: 10.6084/m9.figshare.17213523
title: Quantifying the rate and predictors of occult lymph node involvement in patients with clinically node-negative non-small cell lung cancer

description: It is essential to evaluate the risk of occult lymph node (LN) disease in early-stage non-small cell lung cancer (NSCLC), especially because delivering stereotactic ablative radiotherapy (SABR) assumes no occult spread. This study was designed to assist clinicians in roughly quantifying this risk for cN0 NSCLC. The National Cancer Data Base was queried for cN0 cM0 lung squamous cell or adenocarcinoma who underwent surgery and LN dissection without neoadjuvant therapy. Statistics included multivariable logistic regression to evaluate factors associated with pN + disease. 109,964 patients were included. For tumors with size ≤1.0, 1.1–2.0, 2.1–3.0, 3.1–4.0, 4.1–5.0, 5.1–6.0, 6.1–7.0, and &gt;7.0 cm, the pN + rate was 4.4, 7.7, 12.9, 18.0, 20.2, 22.5, 24.4, and 26.4%, respectively. When examining patients with more complete LN dissections (defined as removal of at least 10 LNs), the respective values were 6.6, 11.5, 17.6, 25.3, 26.8, 29.7, 30.7, and 31.6%. Moderately-poorly differentiated disease and adenocarcinomas were associated with a higher rate of pN + disease (<i>p</i> p p This nationwide study can allow clinicians to roughly estimate the rate of occult LN disease in cN0 NSCLC. These data can also assist in guiding enrollment on randomized trials of SABR ± immunotherapy, individualizing follow-up imaging surveillance, and patient counseling to avoid post-diagnosis delays.
DOI: 10.6084/m9.figshare.17213523.v2
title: Quantifying the rate and predictors of occult lymph node involvement in patients with clinically node-negative non-small cell lung cancer

description: It is essential to evaluate the risk of occult lymph node (LN) disease in early-stage non-small cell lung cancer (NSCLC), especially because delivering stereotactic ablative radiotherapy (SABR) assumes no occult spread. This study was designed to assist clinicians in roughly quantifying this risk for cN0 NSCLC. The National Cancer Data Base was queried for cN0 cM0 lung squamous cell or adenocarcinoma who underwent surgery and LN dissection without neoadjuvant therapy. Statistics included multivariable logistic regression to evaluate factors associated with pN + disease. 109,964 patients were included. For tumors with size ≤1.0, 1.1–2.0, 2.1–3.0, 3.1–4.0, 4.1–5.0, 5.1–6.0, 6.1–7.0, and &gt;7.0 cm, the pN + rate was 4.4, 7.7, 12.9, 18.0, 20.2, 22.5, 24.4, and 26.4%, respectively. When examining patients with more complete LN dissections (defined as removal of at least 10 LNs), the respective values were 6.6, 11.5, 17.6, 25.3, 26.8, 29.7, 30.7, and 31.6%. Moderately-poorly differentiated disease and adenocarcinomas were associated with a higher rate of pN + disease (<i>p</i> p p This nationwide study can allow clinicians to roughly estimate the rate of occult LN disease in cN0 NSCLC. These data can also assist in guiding enrollment on randomized trials of SABR ± immunotherapy, individualizing follow-up imaging surveillance, and patient counseling to avoid post-diagnosis delays.
DOI: 10.6084/m9.figshare.17213523.v1
title: Quantifying the rate and predictors of occult lymph node involvement in patients with clinically node-negative non-small cell lung cancer

description: It is essential to evaluate the risk of occult lymph node (LN) disease in early-stage non-small cell lung cancer (NSCLC), especially because delivering stereotactic ablative radiotherapy (SABR) assumes no occult spread. This study was designed to assist clinicians in roughly quantifying this risk for cN0 NSCLC. The National Cancer Data Base was queried for cN0 cM0 lung squamous cell or adenocarcinoma who underwent surgery and LN dissection without neoadjuvant therapy. Statistics included multivariable logistic regression to evaluate factors associated with pN + disease. 109,964 patients were included. For tumors with size ≤1.0, 1.1–2.0, 2.1–3.0, 3.1–4.0, 4.1–5.0, 5.1–6.0, 6.1–7.0, and &gt;7.0 cm, the pN + rate was 4.4, 7.7, 12.9, 18.0, 20.2, 22.5, 24.4, and 26.4%, respectively. When examining patients with more complete LN dissections (defined as removal of at least 10 LNs), the respective values were 6.6, 11.5, 17.6, 25.3, 26.8, 29.7, 30.7, and 31.6%. Moderately-poorly differentiated disease and adenocarcinomas were associated with a higher rate of pN + disease (<i>p</i> p p This nationwide study can allow clinicians to roughly estimate the rate of occult LN disease in cN0 NSCLC. These data can also assist in guiding enrollment on randomized trials of SABR ± immunotherapy, individualizing follow-up imaging surveillance, and patient counseling to avoid post-diagnosis delays.
DOI: 10.14469/hpc/8821
title: Fluoroethane-diethylether-wb97xd/def2svpp

description: Gaussian 16 (C01) calculation
DOI: 10.14469/hpc/8822
title: Fluoroethane-diethylether-wb97xd/aug-cc-pvdz

description: Gaussian 16 (C01) calculation
DOI: 10.14469/hpc/8823
title: Fluoroethane-diethylether-wb97xd/aug-pcSseq1

description: Gaussian 16 (C01) calculation
DOI: 10.14469/hpc/8825
title: Fluoroethane-oDCB-B3LYP+GD3BJ/def2svpp

description: Gaussian 16 (C01) calculation
DOI: 10.14469/hpc/9199
title: C6H5CF3-DMF-wb97xd/aug-pcSseq1

description: Gaussian 16 (C01) calculation
DOI: 10.14469/hpc/9201
title: C6H5CF3-Acetonitrile-wb97xd/aug-pcSseq1

description: Gaussian 16 (C01) calculation
DOI: 10.14469/hpc/9363
title: Fluoroform-Benzene-wb97xd/aug-pcSseq1

description: Gaussian 16 (C01) calculation
DOI: 10.14469/hpc/9396
title: p-C6H4F2-CCl4-B3LYP+GD3BJ/def2svpp

description: Gaussian 16 (C01) calculation
DOI: 10.14469/hpc/9397
title: p-C6H4F2-CCl4-B3LYP/def2svpp

description: Gaussian 16 (C01) calculation
DOI: 10.14469/hpc/9398
title: p-C6H4F2-CCl4-B3LYP+GD3BJ/aug-cc-pvdz

description: Gaussian 16 (C01) calculation
DOI: 10.14469/hpc/9399
title: p-C6H4F2-Acetonitrile-B3LYP/def2svpp

description: Gaussian 16 (C01) calculation
DOI: 10.14469/hpc/9400
title: difluoro(phenyl)borane-hexan-B3LYP+GD3BJ/def2svpp

description: Gaussian 16 (C01) calculation
DOI: 10.14469/hpc/9401
title: difluoro(phenyl)borane-hexan-B3LYP/def2svpp

description: Gaussian 16 (C01) calculation
DOI: 10.14469/hpc/9594
title: p-C6H4F2-Acetone-B3LYP/aug-cc-pvdz

description: Gaussian 16 (C01) calculation
DOI: 10.14469/hpc/9595
title: p-C6H4F2-Acetone-B3LYP+GD3BJ/aug-cc-pvdz

description: Gaussian 16 (C01) calculation
DOI: 10.14469/hpc/9596
title: p-C6H4F2-Acetone-B3LYP+GD3BJ/def2svpp

description: Gaussian 16 (C01) calculation
DOI: 10.14469/hpc/9597
title: p-C6H4F2-Acetonitrile-wb97xd/def2svpp

description: Gaussian 16 (C01) calculation
DOI: 10.14469/hpc/9598
title: difluoro(phenyl)borane-hexan-B3LYP+GD3BJ/aug-cc-pvdz

description: Gaussian 16 (C01) calculation
DOI: 10.14469/hpc/9599
title: difluoro(phenyl)borane-hexan-B3LYP/aug-cc-pvdz

description: Gaussian 16 (C01) calculation
DOI: 10.14469/hpc/10282
title: 1,1,1-trifluoroethane-DCM-MP2/aug-cc-pvdz/NMR

description: Gaussian 16 (C01) calculation
DOI: 10.5281/zenodo.5746735
title: Optical and X-ray data on V496 UMa

description: The optical light curves and X-ray spectra and light curves presented in Kennedy et al. 2022 are given here. The code to reproduce the MCMCs and plots from the paper is given in a github repo.
DOI: 10.5281/zenodo.5746734
title: Optical and X-ray data on V496 UMa

description: The optical light curves and X-ray spectra and light curves presented in Kennedy et al. 2022 are given here. The code to reproduce the MCMCs and plots from the paper is given in a github repo.
DOI: 10.5281/zenodo.6393703
title: Supplementary data for the article "A data-driven simulation of the trophallactic network and intranidal food flow dissemination in ants."

description: Supplementary figures, tables and raw data for the article " "A data-driven simulation of the trophallactic network and intranidal food flow dissemination in ants." <strong>Food sharing can occur in both social and non-social species but is crucial in eusocial species in which only some group members collect food. This food collection but also intranidal food distribution through trophallactic (i.e. mouth-to-mouth) exchanges are fundamental issues in eusocial insects. However, the behavioural rules underlying the regulation and the dynamics of food intake and the resulting networks of exchanges are poorly understood. In this study, we provide new insights </strong><strong>into</strong><strong> the behavioural rules underlying the structure of trophallactic networks and food dissemination dynamics within the colony. We build a simple data-driven model that implements interindividual variability and division of labour to investigate the processes of food accumulation/dissemination inside the nest, both at the individual and collective </strong><strong>levels</strong><strong>. We also test the alternative hypotheses (no variability and no division of labour). Division of labour with inter-individual variability predicts contrary to other models the food dynamics and exchange networks. We establish the links between the interindividual heterogeneity of the trophallactic behaviours, the food flow dynamics and network of trophallactic events</strong>.<strong> Despite the relative simplicity of the model rules, efficient trophallactic networks may emerge as the ones observed in ants leading to better understanding of evolution of such societies.</strong>
DOI: 10.6084/m9.figshare.19322297.v1
title: OLES study.sav

description: The study of online learning environment among clinical year medical students
DOI: 10.6084/m9.figshare.15134046
title: smsk_selection_clupea: results for positive selection in clupeiformes

description: Results of the smsk_selection pipeline for 12 species of clupeiformes<br>
DOI: 10.6084/m9.figshare.15134046.v1
title: smsk_selection_clupea: results for positive selection in clupeiformes

description: Results of the smsk_selection pipeline for 12 species of clupeiformes<br>
DOI: 10.25835/rkp0pfa7
title: Who applies for study abroad scholarships? An exploratory analysis. Supplementary material

description: Supplementary information only.
DOI: 10.3886/e119925v1-113600
title: Data and Code for: Women's Suffrage and Children's Education

description: While a growing literature shows that women, relative to men, prefer greater investment in children, it is unclear whether empowering women produces better economic outcomes. Exploiting plausibly exogenous variation in U.S. suffrage laws, we show that exposure to suffrage during childhood led to large increases in educational attainment for children from disadvantaged backgrounds, especially blacks and Southern whites. We also find that suffrage led to higher earnings alongside education gains, although not for Southern blacks. Using newly-digitized data, we show that education increases are primarily explained by suffrage-induced growth in education spending, although early-life health improvements may have also contributed.
DOI: 10.25835/8mfbqd5n
title: Training Dataset of Stochastic Milkrun-Supplied Flow Lines
DOI: 10.6084/m9.figshare.19447556
title: Supplementary Material for: Outcomes of patients undergoing PCI of ostial coronary lesions- A single center study

description: Introduction Ostial coronary lesions are a subset of proximal coronary lesions which are relatively more difficult to treat and were associated with worse clinical outcomes in the early percutaneous coronary intervention (PCI) era. Data regarding the outcomes of ostial lesions' PCI in the contemporary era is lacking. Methods We conducted a single center, all-comer, prospective registry study, enrolling patients undergoing PCI with the use of contemporary drug eluting stents (DES) between July 2016 and February 2018. Included in the present analysis were only patients treated for proximal lesions. Clinical outcomes were compared between patients undergoing PCI of ostial versus proximal non-ostial lesions. The primary endpoint was target vessel revascularization (TVR). Secondary endpoints included Target lesion revascularization (TLR) and major cardiovascular adverse events (MACE) at 12 months. Results A total of 334 (84.7% male, 67.3±10.7 years) patients were included, of which 91 patients were treated for ostial lesions and 243 were treated for proximal non-ostial lesions. Baseline and procedural characteristics were similar between the two groups. At 12 months TVR and TLR were numerically higher among patients undergoing PCI of ostial versus non-ostial lesions without reaching statistical significance (5.5% vs. 3.3%; p=0.35 and 4.4% vs. 2.5%; p=0.47 respectively). The rate of MACE was similar between the two groups. Conclusion In patients undergoing PCI with the use of contemporary DES, clinical outcomes were similar among patients treated for ostial compared to proximal non-ostial lesions. Larger studies are required to further evaluate the performance of contemporary DES in this subset of lesions.
DOI: 10.6084/m9.figshare.19447556.v1
title: Supplementary Material for: Outcomes of patients undergoing PCI of ostial coronary lesions- A single center study

description: Introduction Ostial coronary lesions are a subset of proximal coronary lesions which are relatively more difficult to treat and were associated with worse clinical outcomes in the early percutaneous coronary intervention (PCI) era. Data regarding the outcomes of ostial lesions' PCI in the contemporary era is lacking. Methods We conducted a single center, all-comer, prospective registry study, enrolling patients undergoing PCI with the use of contemporary drug eluting stents (DES) between July 2016 and February 2018. Included in the present analysis were only patients treated for proximal lesions. Clinical outcomes were compared between patients undergoing PCI of ostial versus proximal non-ostial lesions. The primary endpoint was target vessel revascularization (TVR). Secondary endpoints included Target lesion revascularization (TLR) and major cardiovascular adverse events (MACE) at 12 months. Results A total of 334 (84.7% male, 67.3±10.7 years) patients were included, of which 91 patients were treated for ostial lesions and 243 were treated for proximal non-ostial lesions. Baseline and procedural characteristics were similar between the two groups. At 12 months TVR and TLR were numerically higher among patients undergoing PCI of ostial versus non-ostial lesions without reaching statistical significance (5.5% vs. 3.3%; p=0.35 and 4.4% vs. 2.5%; p=0.47 respectively). The rate of MACE was similar between the two groups. Conclusion In patients undergoing PCI with the use of contemporary DES, clinical outcomes were similar among patients treated for ostial compared to proximal non-ostial lesions. Larger studies are required to further evaluate the performance of contemporary DES in this subset of lesions.
DOI: 10.5281/zenodo.6372578
title: Supplementary materials to "Brakenhoff et al., Application of time series analysis to estimate drawdown from multiple well fields."

description: This repository contains the supplementary material that allow to reproduce all the results from the study submitted to Frontiers journal.
DOI: 10.5281/zenodo.6372577
title: Supplementary materials to "Brakenhoff et al., Application of time series analysis to estimate drawdown from multiple well fields."

description: This repository contains the supplementary material that allow to reproduce all the results from the study submitted to Frontiers journal.