cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.11314505
title: New-Onset Atrial Fibrillation in St-Segment Elevation Myocardial Infarction: Predictors and Impact on Therapy And Mortality

description: Abstract Backgrund: New-onset atrial fibrillation complicating acute myocardial infarction represents an important challenge, with prognostic significance. Objective: To study the incidence, impact on therapy and mortality, and to identify predictors of development of new-onset atrial fibrillation during hospital stay for ST-segment elevation myocardial infarction. Methods: We studied all patients with ST-elevation myocardial infarction included consecutively, between 2010 and 2017, in a Portuguese national registry and compared two groups: 1 - no atrial fibrillation and 2 - new-onset atrial fibrillation. We adjusted a logistic regression model data analysis to assess the impact of new-onset atrial fibrillation on in-hospital mortality and to identify independent predictors of its development. A p value &lt; 0.05 was considered significant. Results: We studied 6325 patients, and new-onset atrial fibrillation was found in 365 (5.8%). Reperfusion was successfully accomplished in both groups with no difference regarding type of reperfusion. In group 2, therapy with beta-blockers and angiotensin-conversion enzyme (ACE) inhibitors/angiotensin receptor blockers (ARBs) was less frequent, 20.6% received anticoagulation at discharge and 16.1% were on triple therapy. New-onset atrial fibrillation was associated with more in-hospital complications and mortality. However, it was not found as an independent predictor of in-hospital mortality. We identified age, prior stroke, inferior myocardial infarction and complete atrioventricular block as independent predictors of new-onset atrial fibrillation. Conclusion: New-onset atrial fibrillation remains a frequent complication of myocardial infarction and is associated with higher rate of complications and in-hospital mortality. Age, prior stroke, inferior myocardial infarction and complete atrioventricular block were independent predictors of new onset atrial fibrillation. Only 36.7% of the patients received anticoagulation at discharge.
DOI: 10.6084/m9.figshare.11314502
title: Thirty-day β-hydroxy-βmethylbutyrate supplementation with a controlled diet does not alter the morphological and morphometric characteristics of the rat diaphragm muscle

description: ABSTRACT Objective To evaluate the β-hydroxy-βmethylbutyrate supplementation influence on the morphological and morphometric characteristics of the diaphragm muscle of rats and verify whether there are sex differences. Methods Experimental study with 48 Wistar rats (24 of each sex) divided into 3 groups: Control Group: in which a daily diet with saline solution was offered; Experimental Group: the same amount of food from the Control group consumed in the previous day and 0.3g/kg of β-hydroxy-βmethylbutyrate; Ad libitum Experimental Group: ad libitum feeding with the same dose of the supplement. The analysis consisted of histomorphometry and classification in diaphragm muscle fiber area bands. The procedures occurred 30 days after the start of the experiment. Data were analyzed using the one-way ANOVA and Tukey tests (p&lt;0.05). Results There was no increase in the cross-sectional area of the diaphragm muscle fibers with the supplementation protocol employed and a similar histological pattern in both sexes. No significant changes were observed in muscle fiber size ranges in the supplemented groups, suggesting that there was no hypertrophy of muscle fibers. Conclusion This study suggests that β-hydroxy-βmethylbutyrate supplementation does not cause changes in the morphological and morphometric characteristics of the diaphragm muscle, regardless of sex.
DOI: 10.6084/m9.figshare.11314514.v1
title: Limited Evidence Suggests Benefits of Single Visit Revascularization Endodontic Procedures - A Systematic Review

description: Abstract Revascularization endodontic procedures commonly require multiple treatment sessions. However, single visit procedures may be advantageous from the clinical and patient management standpoints. The purpose of this review was to evaluate the outcomes of single-visit revascularization endodontic procedures for the management of immature permanent teeth with non-vital pulp. Two electronic databases (Scopus and PubMed) were searched, from their inception to July 2018, for studies that assessed clinical and/or radiographic and/or histologic outcomes of single-visit revascularization endodontic procedures performed in immature permanent teeth with non-vital pulp. Case reports, animal studies and clinical trials were included. The quality of case reports was appraised by Joanna Briggs Institute Critical Appraisal Checklist for Case Reports. The quality of randomized clinical trials was assessed by the revised Cochrane risk of bias tool for randomized trials. The risk of bias for animal studies was assessed using SYRCLE’s risk of bias tool. Tabulation followed by narrative synthesis was used to draw conclusions. Seven studies satisfied the selection criteria. Five were classified as case reports, one as a randomized clinical trial and one as animal study. The latter presented with a high risk of bias, whilst the remaining showed a low risk. The evidence supporting the potential use of single-visit revascularization endodontic procedures is scarce. Successful single-visit revascularization endodontic procedures commonly include the use of high concentrations of sodium hypochlorite and EDTA combined with the use of agitation systems. Further clinical trials with long term follow up are needed to confirm the results of the current review.
DOI: 10.6084/m9.figshare.11314496
title: Nutritional status of elderly assisted in primary care and their relationship with social determinants of health

description: ABSTRACT Objective To review the influence of social determinants of health in the nutritional status of the elderly assisted in a primary care Unit in a Recife, Pernambuco, Brazil, community. Methods This was a cross-sectional study with an analytical approach. The universe was composed of 129 elderly attending a family health unit in Recife, Pernambuco, Brazil. The data were collected according to a protocol. The effect of the association of independent variables with the body mass index was estimated using hierarchical logistic regression models, simple and multiple multinomial. The significance level was set at 5%. Results There was a higher percentage of elderly people with excess weight (52.34%) in the assessment of body mass index. On analysis of the Mini nutritional assessment, the risk of malnutrition was 38.76%. On analysis of the calf circumference 13.39% of the elderly were malnourished. In the final model, the criteria for maintaining the elderly patients were the following: excess weight, marital status, hypertension, osteoarthritis and sewer destination. Elderly widowers had a higher chance (OR=5.17) of having excess weight and not to have sewage network serving their home and be hypertense (OR=2.71 e 2.83). The fact that the elderly have osteoarthritis also indicated a greater chance (OR=3.76) that they present excess weight. Conclusion Among the social determinants of health, the nutritional status of the elderly was associated with marital status, high blood pressure, osteoarthritis and basic sanitation. The social setting of the elderly is associated with their nutritional status.
DOI: 10.6084/m9.figshare.11314502.v1
title: Thirty-day β-hydroxy-βmethylbutyrate supplementation with a controlled diet does not alter the morphological and morphometric characteristics of the rat diaphragm muscle

description: ABSTRACT Objective To evaluate the β-hydroxy-βmethylbutyrate supplementation influence on the morphological and morphometric characteristics of the diaphragm muscle of rats and verify whether there are sex differences. Methods Experimental study with 48 Wistar rats (24 of each sex) divided into 3 groups: Control Group: in which a daily diet with saline solution was offered; Experimental Group: the same amount of food from the Control group consumed in the previous day and 0.3g/kg of β-hydroxy-βmethylbutyrate; Ad libitum Experimental Group: ad libitum feeding with the same dose of the supplement. The analysis consisted of histomorphometry and classification in diaphragm muscle fiber area bands. The procedures occurred 30 days after the start of the experiment. Data were analyzed using the one-way ANOVA and Tukey tests (p&lt;0.05). Results There was no increase in the cross-sectional area of the diaphragm muscle fibers with the supplementation protocol employed and a similar histological pattern in both sexes. No significant changes were observed in muscle fiber size ranges in the supplemented groups, suggesting that there was no hypertrophy of muscle fibers. Conclusion This study suggests that β-hydroxy-βmethylbutyrate supplementation does not cause changes in the morphological and morphometric characteristics of the diaphragm muscle, regardless of sex.
DOI: 10.6084/m9.figshare.11314490
title: Relationship between overweight at 6 years of age and socioeconomic conditions at birth, breastfeeding, initial feeding practices and birth weight

description: ABSTRACT Objective To review the relationship between overweight at 6 years of age and socioeconomic conditions at birth, breastfeeding, early feeding practices and birth weight. Methods A cross-sectional study was carried out involving 473 six-year-old schoolchildren from public and private schools living in a municipality in Southern Brazil. Sociodemographic and breastfeeding data and other initial feeding practices were obtained through interviews with the mothers at home. Birth weight and gestational age were obtained from the child’s health card. Anthropometric data of the schoolchildren were collected during school visits. Bivariate and multivariate analyzes were performed using the Poisson Regression between the independent variables and overweight. Results The prevalence of overweight was 33.2%; 83.2% of the children were breastfed and out of these, 48.4% were breastfed only in the first six months. Non-breastfed children exhibited a 20% higher overweight prevalence (PR=1.20; 95%CI 1.13; 1.28). Children with exclusive breastfeeding for six months exhibited a lower overweight prevalence (PR=0.94; 95%CI 0.89; 0.99). Conclusion In this study, breastfeeding showed to be a protective factor for overweight.
DOI: 10.6084/m9.figshare.11314493
title: Oral insulin improves metabolic parameters in high fat diet fed rats

description: ABSTRACT Introduction/Aim: The gut has shown to have a pivotal role on the pathophysiology of metabolic disease. Food stimulation of distal intestinal segments promotes enterohormones secretion influencing insulin metabolism. In diabetic rats, oral insulin has potential to change intestinal epithelium behavior. This macromolecule promotes positive effects on laboratorial metabolic parameters and decreases diabetic intestinal hypertrophy. This study aims to test if oral insulin can influence metabolic parameters and intestinal weight in obese non-diabetic rats. Methods: Twelve weeks old Wistar rats were divided in 3 groups: control (CTRL) standard chow group; high fat diet low carbohydrates group (HFD) and HFD plus daily oral 20U insulin gavage (HFD+INS). Weight and food consumption were weekly obtained. After eight weeks, fasting blood samples were collected for laboratorial analysis. After euthanasia gut samples were isolated. Results: Rat oral insulin treatment decreased body weight gain (p&lt;0,001), fasting glucose and triglycerides serum levels (p&lt;0,05) an increased intestinal weight of distal ileum (P&lt;0,05). Animal submitted to high fat diet presented higher levels of HOMA-IR although significant difference to CT was not achieved. HOMA-beta were significantly higher (p&lt;0.05) in HFD+INS. Visceral fat was 10% lower in HFD+INS but the difference was not significant. Conclusions: In non-diabetic obese rats, oral insulin improves metabolic malfunction associated to rescue of beta-cell activity.
DOI: 10.6084/m9.figshare.11314496.v1
title: Nutritional status of elderly assisted in primary care and their relationship with social determinants of health

description: ABSTRACT Objective To review the influence of social determinants of health in the nutritional status of the elderly assisted in a primary care Unit in a Recife, Pernambuco, Brazil, community. Methods This was a cross-sectional study with an analytical approach. The universe was composed of 129 elderly attending a family health unit in Recife, Pernambuco, Brazil. The data were collected according to a protocol. The effect of the association of independent variables with the body mass index was estimated using hierarchical logistic regression models, simple and multiple multinomial. The significance level was set at 5%. Results There was a higher percentage of elderly people with excess weight (52.34%) in the assessment of body mass index. On analysis of the Mini nutritional assessment, the risk of malnutrition was 38.76%. On analysis of the calf circumference 13.39% of the elderly were malnourished. In the final model, the criteria for maintaining the elderly patients were the following: excess weight, marital status, hypertension, osteoarthritis and sewer destination. Elderly widowers had a higher chance (OR=5.17) of having excess weight and not to have sewage network serving their home and be hypertense (OR=2.71 e 2.83). The fact that the elderly have osteoarthritis also indicated a greater chance (OR=3.76) that they present excess weight. Conclusion Among the social determinants of health, the nutritional status of the elderly was associated with marital status, high blood pressure, osteoarthritis and basic sanitation. The social setting of the elderly is associated with their nutritional status.
DOI: 10.6084/m9.figshare.11314481
title: Composition of a maternal high fat diet rich in satured fats and omega 3 in gestation and lactation for studies with rodents

description: ABSTRACT Objective To prepare a high fat diet rich in satured fatty acids and supplemented with omega 3 for experimental studies in rodents. Methods Purified industrial ingredients and flaxseed oil as a source of omega 3 at a concentration of 3.5% (v/w) were used in the elaboration of the diets. Centesimal and nutritional compositions, fatty acids profile and dietary intake were evaluated. Serum levels of total protein, albumin, cholesterol and glucose in pregnant rats were verified. The offspring were assessed with regard to body mass and waist circumference. Statistical analysis was performed using the Kolmogorov-Smirnov, Anova One-Way test and Bonferroni post-test. Results High fat and high fat with omega 3 diets presented, respectively, 37% and 36% saturated fat, and the lipid amount was 80% higher than the American Institute of Nutrition 93G control diet. The omega 3 content was 50% higher in the high fat with omega 3 diet. There was no difference in consumption of diet types in weight (grams). The dams that received the High fat diet developed hypercholesterolemia and their High fat offspring exhibited higher body mass on the 1st day of life and increased abdominal circumference on the 30th day of life compared to the control and the high fat with omega 3 offspring. Conclusion The formulated diets with a higher amount of saturated fatty acids meet the nutritional requirements of the gestation and lactation period. The high fat diet with omega 3 was able to attenuate the changes observed in dams and their offspring.
DOI: 10.6084/m9.figshare.11314490.v1
title: Relationship between overweight at 6 years of age and socioeconomic conditions at birth, breastfeeding, initial feeding practices and birth weight

description: ABSTRACT Objective To review the relationship between overweight at 6 years of age and socioeconomic conditions at birth, breastfeeding, early feeding practices and birth weight. Methods A cross-sectional study was carried out involving 473 six-year-old schoolchildren from public and private schools living in a municipality in Southern Brazil. Sociodemographic and breastfeeding data and other initial feeding practices were obtained through interviews with the mothers at home. Birth weight and gestational age were obtained from the child’s health card. Anthropometric data of the schoolchildren were collected during school visits. Bivariate and multivariate analyzes were performed using the Poisson Regression between the independent variables and overweight. Results The prevalence of overweight was 33.2%; 83.2% of the children were breastfed and out of these, 48.4% were breastfed only in the first six months. Non-breastfed children exhibited a 20% higher overweight prevalence (PR=1.20; 95%CI 1.13; 1.28). Children with exclusive breastfeeding for six months exhibited a lower overweight prevalence (PR=0.94; 95%CI 0.89; 0.99). Conclusion In this study, breastfeeding showed to be a protective factor for overweight.
DOI: 10.6084/m9.figshare.11314493.v1
title: Oral insulin improves metabolic parameters in high fat diet fed rats

description: ABSTRACT Introduction/Aim: The gut has shown to have a pivotal role on the pathophysiology of metabolic disease. Food stimulation of distal intestinal segments promotes enterohormones secretion influencing insulin metabolism. In diabetic rats, oral insulin has potential to change intestinal epithelium behavior. This macromolecule promotes positive effects on laboratorial metabolic parameters and decreases diabetic intestinal hypertrophy. This study aims to test if oral insulin can influence metabolic parameters and intestinal weight in obese non-diabetic rats. Methods: Twelve weeks old Wistar rats were divided in 3 groups: control (CTRL) standard chow group; high fat diet low carbohydrates group (HFD) and HFD plus daily oral 20U insulin gavage (HFD+INS). Weight and food consumption were weekly obtained. After eight weeks, fasting blood samples were collected for laboratorial analysis. After euthanasia gut samples were isolated. Results: Rat oral insulin treatment decreased body weight gain (p&lt;0,001), fasting glucose and triglycerides serum levels (p&lt;0,05) an increased intestinal weight of distal ileum (P&lt;0,05). Animal submitted to high fat diet presented higher levels of HOMA-IR although significant difference to CT was not achieved. HOMA-beta were significantly higher (p&lt;0.05) in HFD+INS. Visceral fat was 10% lower in HFD+INS but the difference was not significant. Conclusions: In non-diabetic obese rats, oral insulin improves metabolic malfunction associated to rescue of beta-cell activity.
DOI: 10.6084/m9.figshare.11314478
title: Determination of factors affecting dairy cattle: a case study of Ardahan province using data mining algorithms

description: ABSTRACT This study was conducted to compare predictive performances of different data-mining algorithms for determining factors influencing the average daily milk yield at dairy cattle enterprises of Ardahan province, located in the Eastern Anatolia region of Turkey. The algorithms employed in the present study were Classification and Regression Tree (CART), Chi-Square Automatic Interaction Detector (CHAID), Exhaustive Chi-Square Automatic Interaction Detector (Exhaustive CHAID), Multivariate Adaptive Regression Splines (MARS), and Multilayer Perceptron (MLP). The MARS algorithm outperformed the other algorithms in the study. Visual results of CART revealed that the culture-breed cows with a lactation length greater than 237.500 days had the highest milk yield (10.64 kg/day). Culture-breed cows calving earlier than the 4th month gave the highest yield of approximately 10 kg/day in the regression tree of CHAID. The Exhaustive CHAID results were almost the same as the structure of the CHAID. The use of MARS may provide an opportunity to detect factors affecting milk production (breed, feed supply, type of milking, mastitis control, cow year group, and lactation length) and their interactions. Moreover, the MARS algorithm may be useful in making an accurate decision about increasing milk yield per cow.
DOI: 10.6084/m9.figshare.11314472
title: Terpene Esters from Natural Products: Synthesis and Evaluation of Cytotoxic Activity

description: ABSTRACT Natural steroids and triterpenes such as b-sitosterol, stigmasterol, lupeol, ursolic and betulinic acids were transformed into its hexanoic and oleic esters, to evaluate the influence of chemical modification towards the cytotoxic activities against tumor cells. The derivatives were evaluated against five tumor cell lines [OVCAR-8 (ovarian carcinoma); SF-295 (glioblastoma); HCT-116 (colon adenocarcinoma); HL-60 (leukemia); and PC-3 (prostate carcinoma)] and the results showed only betulinic acid hexyl ester exhibits cytotoxic potential activity.
DOI: 10.6084/m9.figshare.11314481.v1
title: Composition of a maternal high fat diet rich in satured fats and omega 3 in gestation and lactation for studies with rodents

description: ABSTRACT Objective To prepare a high fat diet rich in satured fatty acids and supplemented with omega 3 for experimental studies in rodents. Methods Purified industrial ingredients and flaxseed oil as a source of omega 3 at a concentration of 3.5% (v/w) were used in the elaboration of the diets. Centesimal and nutritional compositions, fatty acids profile and dietary intake were evaluated. Serum levels of total protein, albumin, cholesterol and glucose in pregnant rats were verified. The offspring were assessed with regard to body mass and waist circumference. Statistical analysis was performed using the Kolmogorov-Smirnov, Anova One-Way test and Bonferroni post-test. Results High fat and high fat with omega 3 diets presented, respectively, 37% and 36% saturated fat, and the lipid amount was 80% higher than the American Institute of Nutrition 93G control diet. The omega 3 content was 50% higher in the high fat with omega 3 diet. There was no difference in consumption of diet types in weight (grams). The dams that received the High fat diet developed hypercholesterolemia and their High fat offspring exhibited higher body mass on the 1st day of life and increased abdominal circumference on the 30th day of life compared to the control and the high fat with omega 3 offspring. Conclusion The formulated diets with a higher amount of saturated fatty acids meet the nutritional requirements of the gestation and lactation period. The high fat diet with omega 3 was able to attenuate the changes observed in dams and their offspring.
DOI: 10.6084/m9.figshare.11314472.v1
title: Terpene Esters from Natural Products: Synthesis and Evaluation of Cytotoxic Activity

description: ABSTRACT Natural steroids and triterpenes such as b-sitosterol, stigmasterol, lupeol, ursolic and betulinic acids were transformed into its hexanoic and oleic esters, to evaluate the influence of chemical modification towards the cytotoxic activities against tumor cells. The derivatives were evaluated against five tumor cell lines [OVCAR-8 (ovarian carcinoma); SF-295 (glioblastoma); HCT-116 (colon adenocarcinoma); HL-60 (leukemia); and PC-3 (prostate carcinoma)] and the results showed only betulinic acid hexyl ester exhibits cytotoxic potential activity.