cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.4560502.v2
title: Lithium response in bipolar disorders and core clock genes expression

description: <b>Objectives:</b> We examine whether the lithium response is associated with changes in the expression of core clock genes. <b>Methods:</b> The effect of a therapeutic concentration of lithium (1 mM) on the expression levels of 17 circadian genes was examined in lymphoblastoid cell lines (LCLs) derived from two well-characterized groups of bipolar disorder patients, defined as lithium non-responders (NR, <i>n</i> = 20) or excellent responders (ER, <i>n</i> = 16). Quantitative real-time PCR (qRT-PCR) was conducted at 2, 4 and 8 days (d2, d4 and d8) with and without lithium exposure. <b>Results:</b> At d2, in ER only, <i>BHLHE41</i>, <i>RORA</i>, <i>PER1</i>, <i>ARNTL</i>, <i>CRY2</i>, <i>BHLHE40</i> and <i>CSNK1D</i> were upregulated, whereas <i>NR1D1</i> was downregulated. At d4, in ER only, <i>CRY1</i> was downregulated. At d8, in NR only, <i>GSK3β</i> was upregulated and <i>DBP</i>, <i>TIMELESS</i> and <i>CRY1</i> were downregulated. Significant Group × Lithium interactions existed for <i>NR1D1</i> at d2 (<i>P</i> = 0.02), and <i>CRY1</i> at d4 (<i>P</i> = 0.02). Longitudinal analyses showed differential temporal evolutions between NR and ER (significant Time × Group interaction) for <i>PER3</i>, <i>NR1D1</i>, <i>DBP</i>, <i>RORA</i>, <i>CSNK1D and TIMELESS</i>; and a significant Time × Lithium interaction for <i>NR1D1</i>. Coexpression data analyses suggested distinct groups of circadian genes concurrently modulated by lithium. <b>Conclusions:</b> In LCLs, lithium influences expression of circadian genes with differences in amplitude and kinetics according to the patient’s lithium response status.
DOI: 10.6084/m9.figshare.4560505.v1
title: Common and specific genes and peripheral biomarkers in children and adults with Attention-Deficit/Hyperactivity Disorder

description: <b>Objectives:</b> Elucidating the biological mechanisms involved in Attention-deficit/hyperactivity disorder (ADHD) has been challenging. Relatively unexplored is the fact that these mechanisms can differ with age. <b>Methods:</b> We present an overview on the major differences between children and adults with ADHD, describing several studies from genomics to metabolomics performed in ADHD children and in adults. A systematic search (up until February, 2016) was conducted. <b>Results:</b> From a PRISMA flow-chart, a total of eligibility 350 studies from genomics and metabolomics were found for cADHD and 91 for aADHD. For children, associations were found for genes belonging to dopaminergic (SLC6A3, DRD4, MAOA) and neurodevelopmental (LPHN3, DIRAS2) systems and OPRM1 (Yates Corrected p = 0.016; OR = 2.27 95%CI:1.15-4.47). Studies of adults have implicated circadian rhythms genes, HTR2A, MAOB and a more generic neurodevelopmental/neurite outgrowth network (BCHE, SNAP25, BAIAP2, NOS1/NO, KCNIP4, SPOCK3; Yates Corrected p = 0.007; OR= 3.30 95%CI:1.33-8.29). In common among cADHD and aADHD, the most significant findings are for oxidative stress proteins (MAD, SOD, PON1, ARES, TOS, TAS, OSI), and, in the second level, DISC1, DBH, DDC, microRNA and adiponectin. <b>Conclusions:</b> Through a convergent functional genomics, this review contributes to clarify which genetic/biological mechanisms differ with age. The effects of some genes do not change throughout lifetime, whereas others are linked to age specific stages. Additional research and further studies are needed to generate firmer conclusions that might someday be useful for predicting the remission and persistence of the disorder. Although the limitations, some of these genes/proteins could be potential useful biomarkers to discriminate cADHD versus aADHD.
DOI: 10.6084/m9.figshare.4560502.v1
title: Lithium response in bipolar disorders and core clock genes expression.

description: Objectives: We examine if the lithium response is associated with changes in core clock genes expressions. Methods: The effect of a therapeutic concentration of lithium (1mM) on the expression levels of 17 circadian genes, was examined in lymphoblastoid cell lines (LCLs) derived from two well-characterized groups of BD patients, defined as lithium non-responders (NR, n = 20) or excellent responders (ER, n = 16). Quantitative real-time PCR (qRT-PCR) were conducted at 2, 4 and 8 days (d2, d4, d8) with and without lithium exposure. Results: At d2, in ER only, <i>BHLHE41, RORA, PER1, ARNTL, CRY2, BHLHE40, and CSNK1D</i> were upregulated, whereas <i>NR1D1</i> was downregulated. At d4, in ER only, <i>CRY1</i> was downregulated. At d8, in NR only, <i>GSK3β</i> was upregulated and <i>DBP, TIMELESS</i> and <i>CRY1</i> were downregulated. Significant Group×Lithium interactions existed for <i>NR1D1</i> at d2 (p = 0.02), and <i>CRY1</i> at d4 (p = 0.02). Longitudinal analyses showed differential temporal evolutions between NR and ER (significant Time×Group interaction) for <i>PER3, NR1D1, DBP, RORA, CSNK1D, and TIMELESS</i>; and a significant Time×Lithium interaction for <i>NR1D1</i>. Co-expression data analyses suggested distinct groups of circadian genes concurrently modulated by lithium. Conclusions: In LCLs, lithium influences circadian genes expressions with differences in amplitude and kinetics according to the patient’s lithium response status.
DOI: 10.6084/m9.figshare.4560421
title: UK Biobank_SOP_cardiovascular magnetic resonance

description: Current SOPs for the analysis of cardiovascular magnetic resonance imaging funded by the BHF PG/14/89/31194
DOI: 10.6084/m9.figshare.4560427
title: Leveraging Evolution Dynamics to Generate Benchmark Complex Networks with Community Structures

description: The dataset contains the benchmark graphs which analyzed for the paper. Each compressed file starting with the name "iteration k" is consisting 375 graphs. These graphs are generated by using a growing model based on evolution dynamics. The algorithm is also available in as R package (evolutionaryBenchmark_0.5-1.zip).<br>
DOI: 10.6084/m9.figshare.4560415
title: Tianmuthredo nigrodorsata Wei, 1997, holotype

description: The photos were taken by A. Taeger in 2009 with a Panasonic DMC FS3, without further examiation of the specimen.<br>The holotype is housed in the Central South University of Forestry and Technology, Changsha, China.<br>
DOI: 10.6084/m9.figshare.4560421.v1
title: UK Biobank_SOP_cardiovascular magnetic resonance

description: Current SOPs for the analysis of cardiovascular magnetic resonance imaging funded by the BHF PG/14/89/31194
DOI: 10.6084/m9.figshare.4560409
title: Gut content analysis of extra- and intraguild prey in ground dwelling predators and field densities of prey and predators

description: The experiment took place in 10 organic and conventional spring barley fields in south-central Sweden located in pairs during the early barley tillering ('Early' period) and at barley stem extension/heading stage ('Late' period).<br><br><br>3680 generalist ground-dwelling predators (carabids and spiders) were collected for gut content analysis with primers targeting: <br>- extraguild prey: aphids, thrips, dipterans, springtails and earthworms<br>- intraguild prey: Carabids: <i>Harpalus, Pterostichus, Poecilus, Bembidion</i>; and Spiders: Lycosidae, Linyphiidae, <i>Pachygnatha</i> spp; other: <i>Coccinella septempunctata</i> and lacewings.<br><br>Extraguild prey density and intraguild prey activity density were recorded at Early and Late period.
DOI: 10.6084/m9.figshare.4560415.v1
title: Tianmuthredo nigrodorsata Wei, 1997, holotype

description: The photos were taken by A. Taeger in 2009 with a Panasonic DMC FS3, without further examiation of the specimen.<br>The holotype is housed in the Central South University of Forestry and Technology, Changsha, China.<br>
DOI: 10.6084/m9.figshare.4560409.v1
title: Gut content analysis of extra- and intraguild prey in ground dwelling predators and field densities of prey and predators

description: The experiment took place in 10 organic and conventional spring barley fields in south-central Sweden located in pairs during the early barley tillering ('Early' period) and at barley stem extension/heading stage ('Late' period).<br><br><br>3680 generalist ground-dwelling predators (carabids and spiders) were collected for gut content analysis with primers targeting: <br>- extraguild prey: aphids, thrips, dipterans, springtails and earthworms<br>- intraguild prey: Carabids: <i>Harpalus, Pterostichus, Poecilus, Bembidion</i>; and Spiders: Lycosidae, Linyphiidae, <i>Pachygnatha</i> spp; other: <i>Coccinella septempunctata</i> and lacewings.<br><br>Extraguild prey density and intraguild prey activity density were recorded at Early and Late period.
DOI: 10.6084/m9.figshare.4560376
title: Visits to "Mery Streep" Wikipedia Page updated to half-January

description: After a speech in which Meryl Streep mentioned Trump and backlash, her notoriety clearly went up. We analyze the visits in the Spanish wikipedia and check the time it takes for them go to to baseline levels. <br>
DOI: 10.6084/m9.figshare.4560391
title: Pre-print: Predictors of cold and pressure pain tolerance in healthy South African adults. DOI: 10.1093/pm/pnw291

description: <b>Pre-print copy of: </b>Bagwath Persad LA, Kamerman PR, Wadley AL. Predictors of cold and pressure pain tolerance in healthy South African adults. Pain Medicine [Epub ahead of press], 2017. DOI: 10.1093/pm/pnw291, PMID: 28082523 <br><b>Dataset and analysis scripts:</b> 10.6084/m9.figshare.2289385<br><br><b>Abstract: </b><i>Background: </i>Studies on relationships between sex, ethnicity and pain largely have emanated from the US and Europe. We compared cold (CPT) and pressure pain tolerance (PPT) in male and female South Africans of African and European ancestry and assessed whether psychosocial factors (including pain beliefs) predicted differences in pain tolerance. <i>Methods: </i>We recruited 106 (62 female) students of African ancestry and 106 (55 female) of European ancestry and subjected them to a cold-pressor test and pressure algometry. Socioeconomic status (SES), pain catastrophizing, depression, anxiety and pain beliefs were assessed as predictors of differences in pain tolerance. <i>Results: </i>CPT was lower in students of African compared to European ancestry (for both sexes), and PPT was lower in female than male students (for both ethnicities). Men were less accepting of men expressing pain than were women, with males of African ancestry being least accepting. Multivariate analysis identified that being of African ancestry, and particularly a female of African ancestry predicted lower CPT. Anxiety was of borderline interest. Sex was the only significant predictor of PPT on multivariate analysis (PPT females &lt; males) and catastrophizing was of borderline interest. Female sex and African ancestry were important predictors of acceptance of expression of pain in males. SES was a variable of interest. <i>Conclusions:</i> Despite a different cultural and social background from US and European cohorts, we saw similar patterns of sex and ethnic differences in CPT and PPT in an African cohort. Traditional psychosocial predictors of pain sensitivity were identified as being of interest but were not strongly associated.
DOI: 10.6084/m9.figshare.4560394
title: Introduction of the leak-before-break (LBB) concept for cast iron water pipes on the basis of laboratory experiments

description: Failure of cast iron water mains in Australia is a common occurrence. Water utilities are seeking solutions to optimise the renewal and rehabilitation of ageing cast iron critical water mains (diameter ≥ 300 mm). Failure pressures of three large-diameter cast iron pipe specimens (600 mm in diameter) were tested. A large corrosion patch was machined onto each pipe section to initiate pipe failure. A large corrosion patch and significant reduction (&gt;90%) of pipe wall thickness were needed to fail the tested pipe specimens. All three pipes under test exhibited leaking before bursting, indicating that the concept of leak-before-break (LBB) could be used for pipe failure prevention. In addition, LBB provides valuable information that could be added to the pipe asset database to make better management decisions on repair or replacement along with all other asset information. The study also found that small corrosion patches (&lt;50 mm) with low remaining wall thickness may cause pipe leaks, but are less likely to cause major pipe bursts.
DOI: 10.6084/m9.figshare.4560427.v1
title: The benchmark graphs generated by using evolution dynamics with community structures

description: The attached files are benchmark graphs generated by our algorithms based on evolution dynamics. Refer following article for further details:<br>
DOI: 10.6084/m9.figshare.4560394.v1
title: Introduction of the leak-before-break (LBB) concept for cast iron water pipes on the basis of laboratory experiments

description: Failure of cast iron water mains in Australia is a common occurrence. Water utilities are seeking solutions to optimise the renewal and rehabilitation of ageing cast iron critical water mains (diameter ≥ 300 mm). Failure pressures of three large-diameter cast iron pipe specimens (600 mm in diameter) were tested. A large corrosion patch was machined onto each pipe section to initiate pipe failure. A large corrosion patch and significant reduction (&gt;90%) of pipe wall thickness were needed to fail the tested pipe specimens. All three pipes under test exhibited leaking before bursting, indicating that the concept of leak-before-break (LBB) could be used for pipe failure prevention. In addition, LBB provides valuable information that could be added to the pipe asset database to make better management decisions on repair or replacement along with all other asset information. The study also found that small corrosion patches (&lt;50 mm) with low remaining wall thickness may cause pipe leaks, but are less likely to cause major pipe bursts.
DOI: 10.6084/m9.figshare.4560427.v2
title: The code to generate benchmark graphs with ground truth communities based on evolution dynamics along with the benchmark graphs generated by the algorithm.

description: The attached files are benchmark graphs generated by our algorithms based on evolution dynamics. Refer following article for further details:<br>
DOI: 10.6084/m9.figshare.4560427.v4
title: Leveraging Evolution Dynamics to Generate Benchmark Complex Networks with Community Structures

description: The dataset contains the benchmark graphs which analyzed for the paper. Each compressed file starting with the name "iteration k" is consisting 375 graphs. These graphs are generated by using a growing model based on evolution dynamics. The algorithm is also available in as R package (evolutionaryBenchmark_0.5-1.zip).<br>
DOI: 10.6084/m9.figshare.4560391.v4
title: Pre-print: Predictors of cold and pressure pain tolerance in healthy South African adults. DOI: 10.1093/pm/pnw291

description: <b>Pre-print copy of: </b>Bagwath Persad LA, Kamerman PR, Wadley AL. Predictors of cold and pressure pain tolerance in healthy South African adults. Pain Medicine [Epub ahead of press], 2017. DOI: 10.1093/pm/pnw291, PMID: 28082523 <br><b>Dataset and analysis scripts:</b> 10.6084/m9.figshare.2289385<br><br><b>Abstract: </b><i>Background: </i>Studies on relationships between sex, ethnicity and pain largely have emanated from the US and Europe. We compared cold (CPT) and pressure pain tolerance (PPT) in male and female South Africans of African and European ancestry and assessed whether psychosocial factors (including pain beliefs) predicted differences in pain tolerance. <i>Methods: </i>We recruited 106 (62 female) students of African ancestry and 106 (55 female) of European ancestry and subjected them to a cold-pressor test and pressure algometry. Socioeconomic status (SES), pain catastrophizing, depression, anxiety and pain beliefs were assessed as predictors of differences in pain tolerance. <i>Results: </i>CPT was lower in students of African compared to European ancestry (for both sexes), and PPT was lower in female than male students (for both ethnicities). Men were less accepting of men expressing pain than were women, with males of African ancestry being least accepting. Multivariate analysis identified that being of African ancestry, and particularly a female of African ancestry predicted lower CPT. Anxiety was of borderline interest. Sex was the only significant predictor of PPT on multivariate analysis (PPT females &lt; males) and catastrophizing was of borderline interest. Female sex and African ancestry were important predictors of acceptance of expression of pain in males. SES was a variable of interest. <i>Conclusions:</i> Despite a different cultural and social background from US and European cohorts, we saw similar patterns of sex and ethnic differences in CPT and PPT in an African cohort. Traditional psychosocial predictors of pain sensitivity were identified as being of interest but were not strongly associated.
DOI: 10.6084/m9.figshare.4560427.v3
title: The dataset contains the benchmark graphs which analyzed for the paper. Each compressed file starting with the name "iteration k" is consisting 375 graphs. These graphs are generated by using a growing model based on evolution dynamics. The algorithm is also available in as R package (evolutionaryBenchmark_0.5-1.zip).

description: The attached files are benchmark graphs generated by our algorithms based on evolution dynamics. Refer following article for further details:<br>
DOI: 10.6084/m9.figshare.4560391.v3
title: Post-print: Predictors of cold and pressure pain tolerance in healthy South African adults. DOI: 10.1093/pm/pnw291

description: <b>Post-print copy of: </b>Bagwath Persad LA, Kamerman PR, Wadley AL. Predictors of cold and pressure pain tolerance in healthy South African adults. Pain Medicine [Epub ahead of press], 2017. DOI: 10.1093/pm/pnw291, PMID: 28082523 <br><b>Dataset and analysis scripts:</b> 10.6084/m9.figshare.2289385<br><br><b>Abstract: </b><i>Background: </i>Studies on relationships between sex, ethnicity and pain largely have emanated from the US and Europe. We compared cold (CPT) and pressure pain tolerance (PPT) in male and female South Africans of African and European ancestry and assessed whether psychosocial factors (including pain beliefs) predicted differences in pain tolerance. <i>Methods: </i>We recruited 106 (62 female) students of African ancestry and 106 (55 female) of European ancestry and subjected them to a cold-pressor test and pressure algometry. Socioeconomic status (SES), pain catastrophizing, depression, anxiety and pain beliefs were assessed as predictors of differences in pain tolerance. <i>Results: </i>CPT was lower in students of African compared to European ancestry (for both sexes), and PPT was lower in female than male students (for both ethnicities). Men were less accepting of men expressing pain than were women, with males of African ancestry being least accepting. Multivariate analysis identified that being of African ancestry, and particularly a female of African ancestry predicted lower CPT. Anxiety was of borderline interest. Sex was the only significant predictor of PPT on multivariate analysis (PPT females &lt; males) and catastrophizing was of borderline interest. Female sex and African ancestry were important predictors of acceptance of expression of pain in males. SES was a variable of interest. <i>Conclusions:</i> Despite a different cultural and social background from US and European cohorts, we saw similar patterns of sex and ethnic differences in CPT and PPT in an African cohort. Traditional psychosocial predictors of pain sensitivity were identified as being of interest but were not strongly associated.
DOI: 10.5281/zenodo.4012490
title: Oxia Planum: THEMIS and CRISM Spectral and Visual Datasets

description: Imagery and data used for analysis for geological and thermal characterization of Oxia Planum seen in "Geologic and Thermal Characterization of Oxia Planum using Mars Odyssey THEMIS Data" (C.E. Gary-Bicas and A.D. Rogers). Amongst the datasets there are THEMIS (Thermal Emission Imaging System) image stamps "oxia_THEMIS_images.zip" which contains atmospherically corrected and geo-referenced emissivity cubes, CRISM (Compact Reconnaissance Imaging Spectrometer for Mars) image stamp frt00009a16_07_if166l_trr3 (includes atmospheric correction, de-striping, and projection steps). Regions of Interest (ROIs) correspond to analyzed locations to geologic units classified in manuscript (files ending with .roi). ROI files starting with the letter "I" are associated to THEMIS stamps."units.roi" is associated to CRISM stamp within these ROIs there is a denominator spectra for correction. ROI files can be opened with HARRIS ENVI. The ".txt" files are mean spectra output files from the ROIs with spectral data for both CRISM (9a16_.txt, these are ratioed spectra using denominator) and THEMIS (####.txt where the numbers are the last 4 digits of the Stamp ID). There are 2 mineral library files corresponding to spectral libraries for each instrument. "CRISMmin.txt" corresponds to CRISM library data and "comparison_lib_themisres.hdf" to THEMIS data. There are four THEMIS thermal inertia datasets extracted from a THEMIS thermal inertia stamp and divided by the different geologic units classified in paper (####_TI.csv). Lastly, we have two sets of shapefiles that can be imported into Geographic Information Systems like ESRI ArcMap or JMARS. These shapefiles correspond to geologically designated units in the aforementioned manuscript. The zip file titled "Unit Shape Files.zip" has the geologic units individual shape files and associated files as well as crater shape files. The one titled "Unit TI Shape Files.zip" has the shape files for all the classified units in a localized region where we conducted our thermal inertia analysis.
DOI: 10.6084/m9.figshare.12904580.v2
title: Morphology Analysis of CEC using SQQQ media

description: This data set offers information of a size and shape (morphology) analysis preformed on White New Zeland rabbit corneal endothelium cells (CEC) through 3 passages using a SQQQ culture media sequence. tThis information was obtained by three indpendent users with NIH Image J (free license software) Shape Descriptors. We also provide the images from where the data was obtained and the Annova results can be carried out for the three indpenden users that carried out the analysis. Also we provide an ANNOVA for different sequences analyzed and figures of those sequences as a guide. <br><br>S= stimulatory media = proliferative media = PQ=quiescent media = resting media = R
DOI: 10.6084/m9.figshare.12904580
title: Morphology Analysis of CEC using SQQQ media

description: This data set offers information of a size and shape (morphology) analysis preformed on White New Zeland rabbit corneal endothelium cells (CEC) through 3 passages using a SQQQ culture media sequence. tThis information was obtained by three indpendent users with NIH Image J (free license software) Shape Descriptors. We also provide the images from where the data was obtained and the Annova results can be carried out for the three indpenden users that carried out the analysis. Also we provide an ANNOVA for different sequences analyzed and figures of those sequences as a guide. <br><br>S= stimulatory media = proliferative media = PQ=quiescent media = resting media = R
DOI: 10.6084/m9.figshare.12904580.v1
title: Morphology Analysis of CEC using SQQQ media

description: This data set offers information of a size and shape (morphology) analysis preformed on White New Zeland rabbit corneal endothelium cells (CEC) through 3 passages using a SQQQ culture media sequence. tThis information was obtained by three indpendent users with NIH Image J (free license software) Shape Descriptors. We also provide the images from where the data was obtained and the Annova results for the three indpenden users that carried out the analysis. <br><br>S= stimulatory media, Q=Quiescent media.