cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.16573001.v1
title: Supplementary Material for: LOXL2 Inhibitor Attenuates Angiotensin II-Induced Atrial Fibrosis and Vulnerability to Atrial Fibrillation through Inhibition of Transforming Growth Factor Beta-1 Smad2/3 Pathway

description: <b><i>Objectives:</i></b> Angiotensin II (Ang II)-induced atrial fibrosis plays a vital role in the development of atrial fibrillation (AF). Lysyl oxidase-like 2 (LOXL2) plays an essential role in matrix remodeling and fibrogenesis, indicating it may involve fibrosis-associated diseases. This study aims to elucidate the role of LOXL2 in AF, and its specific inhibitor can suppress Ang II-induced inflammatory atrial fibrosis and attenuate the enhanced vulnerability to AF. <b><i>Methods:</i></b> Male mice C57BL/6 were subcutaneously infused with either saline or Ang II (2 mg/kg/day) for 4 weeks. DMSO or LOXL2 inhibitor LOXL2-IN-1 hydrochloride (LOXL2-IN-1) at a dose of 100 μg/kg/day were intraperitoneally injected once daily for 4 weeks. Morphological, histological, and biochemical analyses were performed. AF was induced by transesophageal burst pacing in vivo. <b><i>Results:</i></b> Expression of LOXL2 was increased in serum of AF patients and Ang II-treated mice. LOXL2-IN-1 significantly attenuated Ang II-induced AF vulnerability, cardiac hypertrophy, atrial inflammation, and fibrosis. LOXL2-IN-1 suppressed Ang II-induced expression of transforming growth factor beta-1 (TGF-β1) and collagen I and phosphorylation of Smad2/3 in atrial tissue. <b><i>Conclusions:</i></b> LOXL2 is a target of AF, and its inhibitor prevents atrial fibrosis and attenuated enhanced vulnerability to AF potentially through the TGF-β/Smad pathway.
DOI: 10.6084/m9.figshare.16573067
title: Supplementary Material for: Einfluss einer achtsamkeitsbasierten Depressionsbehandlung in einer Tagesklinik auf arbeitsbezogene Bewältigungsmuster bei depressiven Patientinnen und Patienten mit berufsbezogenen Konflikten

description: <b><i>Hintergrund:</i></b> Ziel der Studie war es, den Einfluss einer achtsamkeitsbasierten Depressionsbehandlung in einer Tagesklinik auf arbeitsbezogene Bewältigungsmuster bei Patientinnen und Patienten mit einer akuten depressiven Episode und berufsbezogenen Konflikten zu untersuchen. <b><i>Methode:</i></b> In einer Pilotstudie wurden 81 Patientinnen und Patienten mit einer mittelgradigen oder schweren depressiven Episode und berufsbezogenen Konflikten entweder einer tagesklinischen achtsamkeitsbasierten Depressionsbehandlung (mit psychopharmakologischer Medikation bei Bedarf, <i>N</i> = 47) oder einer Kontrollbedingung mit psychopharmakologischer Beratung (<i>N</i> = 34) zugeordnet. Arbeitsbezogene Bewältigungsstile und -muster wurden mit dem Fragebogen für arbeitsbezogenes Erlebens- und Verhaltensmuster (AVEM) zu drei Messzeitpunkten (Beginn, Ende und 8-Monats-Katamnese) untersucht, um gesundheitsgefährdende Risikomuster zu untersuchen. Zudem wurde die psychopathologische Symptombelastung anhand des Beck-Depressions-Inventars (BDI-II) und des Brief-Symptom-Inventory (BSI) gemessen. <b><i>Ergebnisse:</i></b> Die achtsamkeitsbasierte Depressionsbehandlung reduzierte die psychopathologische Symptombelastung signifikant und bewirkte eine positive Veränderung umschriebener gesundheitsgefährdender arbeitsbezogener Bewältigungsstile und Risikomuster hin zu gesundheitsförderlichen Bewältigungsstilen. <b><i>Diskussion:</i></b> Wenngleich Risikomuster durch die achtsamkeitsbasierte Depressionsbehandlung nur zum Teil abgebaut werden konnten, sind die Ergebnisse vielversprechend in Bezug auf gesundheitsförderliche Veränderungen einzelner arbeitsbezogener Bewältigungsstile wie “Verausgabungsbereitschaft”, “Perfektionsstreben”, “Distanzierungsfähigkeit” und “Innere Ruhe/Ausgeglichenheit”. <b><i>Schlussfolgerung:</i></b> Die psychiatrische Versorgung von Patientinnen und Patienten mit einer Depression sollte arbeitsbedingte Stressfaktoren und Konflikte und deren Bewältigung berücksichtigen. Das Behandlungskonzept schließt eine Lücke in der psychiatrischen Versorgung.
DOI: 10.6084/m9.figshare.16572992
title: Supplementary Material for: Triamcinolone Acetonide in the Treatment of Perennial Allergic Rhinitis: A post hoc Analysis of Quality of Life during a Phase III Study

description: <b><i>Introduction:</i></b> Allergic rhinitis (AR) is a disease that affects ≤24% of people in Russia, significantly impairing quality of life (QoL). Intranasal corticosteroids, such as triamcinolone acetonide (TAA), are considered effective drugs for treatment. A post hoc analysis of data (phase III NASANIF trial) examined weekly QoL changes in patients receiving TAA for the treatment of perennial AR (PAR). <b><i>Methods:</i></b> NASANIF (NCT03317015) was a double-blind, parallel group, multicenter, prospective, noninferiority, phase III clinical trial. Patients with PAR were randomized (1:1) to receive TAA or fluticasone propionate (FP) for 4 weeks. Here, a post hoc analysis measures QoL using a shortened Rhinoconjunctivitis Quality of Life Questionnaire (miniRQLQ). Differences in miniRQLQ score were evaluated using a mixed linear model and descriptive statistics. A subgroup analysis was performed in patients with a previous diagnosis of allergic conjunctivitis. <b><i>Results:</i></b> Of 260 patients eligible for randomization, 128 each completed treatment with TAA or FP. Overall and individual domain scores progressively improved and were significantly different versus baseline at week 4 in both treatment groups: LS mean difference TAA: −30.92 (95% CI [−33.01 to −28.83]), <i>p</i> &lt; 0.001, and FP: −31.13 (−33.23 to −29.04), <i>p</i> &lt; 0.001. In both arms of the subgroup, there was a significant reduction in eye symptoms. There was no significant difference between the TAA and FP treatment groups in any analyses. <b><i>Conclusions:</i></b> TAA is effective in improving overall and individual domains of QoL in patients with PAR, over 4 weeks. Patients with a previous diagnosis of allergic conjunctivitis experienced significant improvements in QoL related to the resolution of these symptoms.
DOI: 10.6084/m9.figshare.16572992.v1
title: Supplementary Material for: Triamcinolone Acetonide in the Treatment of Perennial Allergic Rhinitis: A post hoc Analysis of Quality of Life during a Phase III Study

description: <b><i>Introduction:</i></b> Allergic rhinitis (AR) is a disease that affects ≤24% of people in Russia, significantly impairing quality of life (QoL). Intranasal corticosteroids, such as triamcinolone acetonide (TAA), are considered effective drugs for treatment. A post hoc analysis of data (phase III NASANIF trial) examined weekly QoL changes in patients receiving TAA for the treatment of perennial AR (PAR). <b><i>Methods:</i></b> NASANIF (NCT03317015) was a double-blind, parallel group, multicenter, prospective, noninferiority, phase III clinical trial. Patients with PAR were randomized (1:1) to receive TAA or fluticasone propionate (FP) for 4 weeks. Here, a post hoc analysis measures QoL using a shortened Rhinoconjunctivitis Quality of Life Questionnaire (miniRQLQ). Differences in miniRQLQ score were evaluated using a mixed linear model and descriptive statistics. A subgroup analysis was performed in patients with a previous diagnosis of allergic conjunctivitis. <b><i>Results:</i></b> Of 260 patients eligible for randomization, 128 each completed treatment with TAA or FP. Overall and individual domain scores progressively improved and were significantly different versus baseline at week 4 in both treatment groups: LS mean difference TAA: −30.92 (95% CI [−33.01 to −28.83]), <i>p</i> &lt; 0.001, and FP: −31.13 (−33.23 to −29.04), <i>p</i> &lt; 0.001. In both arms of the subgroup, there was a significant reduction in eye symptoms. There was no significant difference between the TAA and FP treatment groups in any analyses. <b><i>Conclusions:</i></b> TAA is effective in improving overall and individual domains of QoL in patients with PAR, over 4 weeks. Patients with a previous diagnosis of allergic conjunctivitis experienced significant improvements in QoL related to the resolution of these symptoms.
DOI: 10.6084/m9.figshare.16572974
title: Supplementary Material for: Therapeutic Potential of Human Nasal Inferior Turbinate-Derived Stem Cells: Microarray Analysis of Multilineage Differentiation

description: <b><i>Introduction:</i></b> Human nasal inferior turbinate-derived stem cells (hNTSCs) are attractive sources of adult stem cells for medical application because they can be easily obtained and cultivated with a highly proliferative capacity. The ability of hNTSCs to differentiate into chondrocytes, osteocytes, and neural cells makes them potential replacement therapeutic candidates in intractable disease. Nevertheless, detailed expression pattern of genes associated with trilineage differentiation (osteogenesis, chondrogenesis, and neurogenesis) in hNTSCs has not been revealed yet. <b><i>Methods:</i></b> In this study, we aimed to evaluate gene expression patterns of various transcription factors and marker genes associated with a particular lineage (osteogenesis, chondrogenesis, and neurogenesis) of differentiation of hNTSCs by DNA microarrays. <b><i>Results:</i></b> In microarrays, 36 transcripts such as E2F transcription factor 1, activating transcription factor 5, and AKR1B10 were upregulated and 36 transcripts such as CA9, PPFIA4, HAS2, and COL4A4 were downregulated in osteogenically differentiated hNTSCs. In chondrogenically differentiated hNTSCs, 3 transcripts (NUDT14, CPA4, and heparin-binding epidermal growth factor-like growth factor) were upregulated and 82 transcripts such as PTGS1, CLEC2D, and TET1 were downregulated. In neurally differentiated hNTSCs, 61 transcripts such as insulin-like growth factor-binding protein-1, nerve growth factor receptor, FGF1, OLFML1, and EPGN were upregulated and 98 transcripts such as ACAN, RUNX2, and C21orf96 were downregulated. In gene ontology (GO) analysis, cell signal-related GO terms were highly expressed. By contrast, catalysis GO terms and GO terms related to oxidoreductase were overrepresented in chondrogenically differentiated hNTSCs and osteogenically differentiated hNTSCs, respectively. <b><i>Conclusion:</i></b> Considering overall results, hNTSCs-specific genetic information may promote further studies on intracellular mechanisms defining key features of these cells.
DOI: 10.6084/m9.figshare.12381689
title: CHP_Uncertainties_Data

description: Examples used in the paper titled "Pricing Non-convexity and Allocating Reserve Costs in Stochastic Electricity Markets". Note that the system parameters and uncertainty parameters of renewables are provided. <br>Paritcuallry, parameters of power demand and generation levels are not provided in this document because they are from a 661-bus utility system and subject to confidential rules. These confidential parameters would be provided based on your request.
DOI: 10.6084/m9.figshare.12381689.v2
title: CHP_Uncertainties_Data

description: Examples used in the paper titled "Pricing Non-convexity and Allocating Reserve Costs in Stochastic Electricity Markets". Note that the system parameters and uncertainty parameters of renewables are provided. <br>Paritcuallry, parameters of power demand and generation levels are not provided in this document because they are from a 661-bus utility system and subject to confidential rules. These confidential parameters would be provided based on your request.
DOI: 10.6084/m9.figshare.12381689.v1
title: CHP_Uncertainties_Data

description: A simple example extended from the IEEE 9-bus test system is provided.
DOI: 10.6084/m9.figshare.16573079
title: datasheet_Aob Plant

description: Differential plastic responses to temperature and nitrogen deposition in the subalpine plant species, <i>Primula farinosa</i> subsp<i>. modesta</i>
DOI: 10.6084/m9.figshare.16573079.v1
title: datasheet_Aob Plant

description: Differential plastic responses to temperature and nitrogen deposition in the subalpine plant species, <i>Primula farinosa</i> subsp<i>. modesta</i>
DOI: 10.6084/m9.figshare.16573037
title: Reconstructing large interaction networks from empirical time series data

description: The R code for implementing MDR S-map and generating synthetic datasets are included. Detailed algorithm of MDR S-map and all necessary functions were provided in the R file recorded in 'Demo_MDR_function.R'. MDR S-map was mainly tested by multi-species Ricker models. To reproduce the main results (Fig. 2), all necessary codes and documents were provided in the file, 'MainResults_RickerModels'. In addition to the i) multi-species Ricker model, we also tested MDR S-map on ii) discrete Lotka-Volterra competition model, iii) Ricker-Beverton-Holt model, and iv) host-parasitoid Nicholson-Bailey model. In addition, time-varying interaction coefficients with seasonal variations were incorporated into all these models, which were also included in the file, 'Additional models'. Detailed analytical guideline was provided in 'Readme.txt' file.<br>
DOI: 10.6084/m9.figshare.16573118
title: Feed Efficiency Genomics in Tilapia

description: Three type of files are available : phenotypic files, genomic file and pedigree file in view to perform genomic predictions.
DOI: 10.5281/zenodo.5148530
title: Cognitive Biases in Building Energy Decisions

description: Raw data and R-code of analysis on online survey for building energy decision making.
description: Data and analysis scripts for the publication Rakitta, M.; Wernery, J. Cognitive Biases in Building Energy Decisions. Sustainability 2021, 13, 9960. https://doi.org/10.3390/su13179960
description: {"references": ["M. Rakitta, J. Wernery, Cognitive Biases in Building Energy Decisions, Sustainability. 13 (2021) 9960. https://doi.org/10.3390/su13179960."]}
DOI: 10.5281/zenodo.5148529
title: Cognitive Biases in Building Energy Decisions

description: Raw data and R-code of analysis on online survey for building energy decision making.
description: Data and analysis scripts for the publication Rakitta, M.; Wernery, J. Cognitive Biases in Building Energy Decisions. Sustainability 2021, 13, 9960. https://doi.org/10.3390/su13179960
description: {"references": ["M. Rakitta, J. Wernery, Cognitive Biases in Building Energy Decisions, Sustainability. 13 (2021) 9960. https://doi.org/10.3390/su13179960."]}
DOI: 10.6084/m9.figshare.16571765
title: Raw Data of Small RNA Sequence

description: Raw Data of Small RNA High Throughput Sequence.
DOI: 10.6084/m9.figshare.16571765.v1
title: Raw Data of Small RNA Sequence

description: Raw Data of Small RNA High Throughput Sequence.
DOI: 10.6084/m9.figshare.14980728.v1
title: Effects of invasive alien species on riparian vegetation over a 20-year time-lapse: a case study from the Tiber river in Central Italy

description: Invasive alien species (IAS) have a severe impact on indigenous vegetation globally, including in riparian ecosystems, which are already subject to severe natural and anthropogenic modifications. This paper presents a case study of the long-term impact of IAS that was carried out on the banks of the Tiber River near Lake Alviano in Central Italy. We compared the vegetation composition from 1998 and 2020, to record IAS invasion after a time-lapse of 22 years. We performed 48 phytosociological relevés in 2020, using the same method that had been used in 1998 (with 46 relevés). The importance of IAS in determining the changes in floristic composition and vegetation dynamics was quantified using chorology, life forms and Ellenberg’s ecological indicator values. Results of our multivariate analysis revealed that <i>Paspalum distichum</i> L. and <i>Amorpha fruticosa</i> L. are the most impactful species, due to their ecological traits that make them highly competitive in disturbed environments. Ellenberg’s indicator values show that the habitat has shifted towards increased eutrophication and warming. The multivariate analysis confirmed a change in species composition and therefore in vegetation, leading to a more monotonous habitat with completely different vegetation types than before. Finally, the consequences for Natura 2000 habitats were assessed. <b>Key policy insights</b>IAS drastically changed and reduced the cover of native vegetation species between 1998 and 2020, changing the environment from an herbaceous marshy vegetation type to a more homogeneous shrubland.The analysed habitat increased in eutrophication driven by 22 years of overgrazing and by the establishment of a nitrogen-fixing IAS (<i>Amorpha fruticosa</i> L.).The most impactful IAS were <i>Paspalum distichum</i> L. and <i>Amorpha fruticosa</i> L.Some IAS (e.g. <i>Paspalum distichum</i> L.) are currently considered characteristic species of some N2000 habitats (e.g. 3280 and 3290), presenting a paradox of the negative effects of invasions and evidencing a gap in the inclusion of important native communities in the EU Habitats Directive worthy and in need of protection. IAS drastically changed and reduced the cover of native vegetation species between 1998 and 2020, changing the environment from an herbaceous marshy vegetation type to a more homogeneous shrubland. The analysed habitat increased in eutrophication driven by 22 years of overgrazing and by the establishment of a nitrogen-fixing IAS (<i>Amorpha fruticosa</i> L.). The most impactful IAS were <i>Paspalum distichum</i> L. and <i>Amorpha fruticosa</i> L. Some IAS (e.g. <i>Paspalum distichum</i> L.) are currently considered characteristic species of some N2000 habitats (e.g. 3280 and 3290), presenting a paradox of the negative effects of invasions and evidencing a gap in the inclusion of important native communities in the EU Habitats Directive worthy and in need of protection.
DOI: 10.6084/m9.figshare.14980728
title: Effects of invasive alien species on riparian vegetation over a 20-year time-lapse: a case study from the Tiber river in Central Italy

description: Invasive alien species (IAS) have a severe impact on indigenous vegetation globally, including in riparian ecosystems, which are already subject to severe natural and anthropogenic modifications. This paper presents a case study of the long-term impact of IAS that was carried out on the banks of the Tiber River near Lake Alviano in Central Italy. We compared the vegetation composition from 1998 and 2020, to record IAS invasion after a time-lapse of 22 years. We performed 48 phytosociological relevés in 2020, using the same method that had been used in 1998 (with 46 relevés). The importance of IAS in determining the changes in floristic composition and vegetation dynamics was quantified using chorology, life forms and Ellenberg’s ecological indicator values. Results of our multivariate analysis revealed that <i>Paspalum distichum</i> L. and <i>Amorpha fruticosa</i> L. are the most impactful species, due to their ecological traits that make them highly competitive in disturbed environments. Ellenberg’s indicator values show that the habitat has shifted towards increased eutrophication and warming. The multivariate analysis confirmed a change in species composition and therefore in vegetation, leading to a more monotonous habitat with completely different vegetation types than before. Finally, the consequences for Natura 2000 habitats were assessed. <b>Key policy insights</b>IAS drastically changed and reduced the cover of native vegetation species between 1998 and 2020, changing the environment from an herbaceous marshy vegetation type to a more homogeneous shrubland.The analysed habitat increased in eutrophication driven by 22 years of overgrazing and by the establishment of a nitrogen-fixing IAS (<i>Amorpha fruticosa</i> L.).The most impactful IAS were <i>Paspalum distichum</i> L. and <i>Amorpha fruticosa</i> L.Some IAS (e.g. <i>Paspalum distichum</i> L.) are currently considered characteristic species of some N2000 habitats (e.g. 3280 and 3290), presenting a paradox of the negative effects of invasions and evidencing a gap in the inclusion of important native communities in the EU Habitats Directive worthy and in need of protection. IAS drastically changed and reduced the cover of native vegetation species between 1998 and 2020, changing the environment from an herbaceous marshy vegetation type to a more homogeneous shrubland. The analysed habitat increased in eutrophication driven by 22 years of overgrazing and by the establishment of a nitrogen-fixing IAS (<i>Amorpha fruticosa</i> L.). The most impactful IAS were <i>Paspalum distichum</i> L. and <i>Amorpha fruticosa</i> L. Some IAS (e.g. <i>Paspalum distichum</i> L.) are currently considered characteristic species of some N2000 habitats (e.g. 3280 and 3290), presenting a paradox of the negative effects of invasions and evidencing a gap in the inclusion of important native communities in the EU Habitats Directive worthy and in need of protection.
DOI: 10.15468/p756ge
title: A new species of Cyrtodactylus Gray, 1827 (Squamata: Gekkonidae) from Western Yunnan, China

description: This dataset contains the digitized treatments in Plazi based on the original journal article Liu, Shuo, Rao, Dingqi (2021): A new species of Cyrtodactylus Gray, 1827 (Squamata: Gekkonidae) from Western Yunnan, China. Journal of Natural History 55 (11 - 12): 713-731, DOI: 10.1080/00222933.2021.1921871, URL: http://dx.doi.org/10.1080/00222933.2021.1921871
DOI: 10.5281/zenodo.5463799
title: Artifacts for Fuzzing SMT Solvers with Diversified Sub-formulas

description: <strong>Fuzzing SMT solvers with Diversified Sub-formulas</strong> Table of Contents Background Install Usage Bugs <strong>Background</strong> <strong>Octopus </strong>is the tool for detecting soundness bugs in SMT solvers. <br> We have submitted 10 valid bug reports for Z3 so far. 7 bugs are confirmed/fixed by developers among these reports. <strong>Install</strong> Octopus itself has few dependencies. It uses Python3 and Python-virtualenv. You can install Python-virtualenv using <code>pip install virtualenv</code> Then install Octopus. <code>virtualenv --python=/usr/bin/python3.6 virenv</code> <code>source virenv/bin/activate</code> <code>cd octopus</code> <code>python3 setup.py install</code> <strong>Usage</strong> You can download SMT instances in SMT COMP 2021 as benchmarks. 2021-05-26 - StarExec Then install and build the SMT solver you want to test. For example: <code>git clone https://github.com/Z3Prover/z3.git</code> <code>python scripts/mk_make.py </code> <code>cd build; make</code> Then Octopus can be used to validate it, for example: <code>octopus --benchmark=/home/SMT2021 --solver=z3 --solverbin=../z3/build/z3 --theory=LIA</code> To run Octopus in multiple cores: <code>octopus --benchmark=/home/SMT2021 --solver=z3 --solverbin=../z3/build/z3 --theory=LIA --cores=20</code> <strong>Bugs</strong> Octopus has detected many new refutational soundness bugs in Z3. Here is a list of issues we reported. https://github.com/Z3Prover/z3/issues/5373 [confirmed]<br> https://github.com/Z3Prover/z3/issues/5443 [reported]<br> https://github.com/Z3Prover/z3/issues/5447 [fixed]<br> https://github.com/Z3Prover/z3/issues/5456 [fixed]<br> https://github.com/Z3Prover/z3/issues/5457 [fixed] <br> https://github.com/Z3Prover/z3/issues/5460 [fixed]<br> https://github.com/Z3Prover/z3/issues/5468 [fixed] <br> https://github.com/Z3Prover/z3/issues/5488 [fixed]<br> https://github.com/Z3Prover/z3/issues/5502 [duplicate]<br> https://github.com/Z3Prover/z3/issues/5508 [reported]<br> https://github.com/Z3Prover/z3/issues/5423 [invalid]