cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.7910/dvn/v1rjpf/iw4eja
title: ykc20160627_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.4001175
title: data and materials of a manuscript

description: <b>In this work, a new physical penetration technology for transdermal administration with traditional Chinese medicine characteristics was established and studied by in-vitro and in-vivo experiments.</b>
DOI: 10.7910/dvn/v1rjpf/kardhd
title: ykc20170827_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.4001148
title: Kenya Data BMC2.sav

description: Demographic and outcome data for Kenya Pilot Study
DOI: 10.7910/dvn/v1rjpf/wvucfy
title: ykc20170519_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.4001148.v1
title: Kenya Data BMC2.sav

description: Demographic and outcome data for Kenya Pilot Study
DOI: 10.7910/dvn/v1rjpf/asrdch
title: ykc20171225_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.4001142
title: Kenya PM+ Pilot Data

description: This data pertains to outcome data of a pilot study of psychosocial intervention using PM+ for survivors of gender-based violence in Kenya
DOI: 10.7910/dvn/v1rjpf/bvrz6z
title: ykc20170717_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.4001040
title: Grassland Data set 2

description: In this data set one species was the focus of our data collection. In the Grassland used for data collection on the NECC Haverhill campus the toadflax was the focus. A trasnsect was randomly selected and walked and the plant data was collected. This included the individual plants height, distance on transect, number of leaves, number of fruits(flowers), and patch. This data was collected and recorded. This was done for 50 individual plants. Two different transects were followed to collect the total data.
DOI: 10.6084/m9.figshare.4001049
title: onetepconv

description: ONETEP Convergence Automation Utility
DOI: 10.6084/m9.figshare.4001049.v1
title: onetepconv

description: ONETEP Convergence Automation Utility
DOI: 10.7910/dvn/v1rjpf/vdenci
title: ykc20160716_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.4001040.v1
title: Grassland Data set 2

description: In this data set one species was the focus of our data collection. In the Grassland used for data collection on the NECC Haverhill campus the toadflax was the focus. A trasnsect was randomly selected and walked and the plant data was collected. This included the individual plants height, distance on transect, number of leaves, number of fruits(flowers), and patch. This data was collected and recorded. This was done for 50 individual plants. Two different transects were followed to collect the total data.
DOI: 10.7910/dvn/v1rjpf/f9dy3j
title: ykc20170604_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/3g12aj
title: ykc20171112_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/mn6gqu
title: ykc20170725_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/tjg9li
title: ykc20160302_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/khg0kh
title: ykc20160728_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/32wmtm
title: ykc20171222_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/aztpq4
title: ykc20170607_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.4000866
title: Autophagy in <i>Dictyostelium</i>: Mechanisms, regulation and disease in a simple biomedical model

description: Autophagy is a fast-moving field with an enormous impact on human health and disease. Understanding the complexity of the mechanism and regulation of this process often benefits from the use of simple experimental models such as the social amoeba <i>Dictyostelium discoideum</i>. Since the publication of the first review describing the potential of <i>D. discoideum</i> in autophagy, significant advances have been made that demonstrate both the experimental advantages and interest in using this model. Since our previous review, research in <i>D. discoideum</i> has shed light on the mechanisms that regulate autophagosome formation and contributed significantly to the study of autophagy-related pathologies. Here, we review these advances, as well as the current techniques to monitor autophagy in <i>D. discoideum</i>. The comprehensive bioinformatics search of autophagic proteins that was a substantial part of the previous review has not been revisited here except for those aspects that challenged previous predictions such as the composition of the Atg1 complex. In recent years our understanding of, and ability to investigate, autophagy in <i>D. discoideum</i> has evolved significantly and will surely enable and accelerate future research using this model.
DOI: 10.6084/m9.figshare.4000866.v1
title: Autophagy in <i>Dictyostelium</i>: Mechanisms, regulation and disease in a simple biomedical model

description: Autophagy is a fast-moving field with an enormous impact on human health and disease. Understanding the complexity of the mechanism and regulation of this process often benefits from the use of simple experimental models such as the social amoeba <i>Dictyostelium discoideum</i>. Since the publication of the first review describing the potential of <i>D. discoideum</i> in autophagy, significant advances have been made that demonstrate both the experimental advantages and interest in using this model. Since our previous review, research in <i>D. discoideum</i> has shed light on the mechanisms that regulate autophagosome formation and contributed significantly to the study of autophagy-related pathologies. Here, we review these advances, as well as the current techniques to monitor autophagy in <i>D. discoideum</i>. The comprehensive bioinformatics search of autophagic proteins that was a substantial part of the previous review has not been revisited here except for those aspects that challenged previous predictions such as the composition of the Atg1 complex. In recent years our understanding of, and ability to investigate, autophagy in <i>D. discoideum</i> has evolved significantly and will surely enable and accelerate future research using this model.
DOI: 10.7910/dvn/v1rjpf/rac17y
title: ykc20171224_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.4000848
title: Progress of endocytic CHRN to autophagic degradation is regulated by RAB5-GTPase and T145 phosphorylation of SH3GLB1 at mouse neuromuscular junctions in vivo

description: Endocytosed nicotinic acetylcholine receptors (CHRN) are degraded via macroautophagy/autophagy during atrophic conditions and are accompanied by the autophagic regulator protein SH3GLB1. The present study addressed the functional role of SH3GLB1 on CHRN trafficking and its implementation. We found an augmented ratio of total SH3GLB1 to threonine-145 phosphorylated SH3GLB1 (SH3GLB1:p-SH3GLB1) under conditions of increased CHRN vesicle numbers. Overexpression of T145 phosphomimetic (T145E) and phosphodeficient (T145A) mutants of SH3GLB1, was found to either slow down or augment the processing of endocytic CHRN vesicles, respectively. Co-expression of the early endosomal orchestrator RAB5 largely rescued the slow processing of endocytic CHRN vesicles induced by T145E. SH3GLB1 phosphomutants did not modulate the expression or colocalization of RAB5 with CHRN vesicles, but instead altered the expression of RAB5 activity regulators. In summary, these findings suggest that SH3GLB1 controls CHRN endocytic trafficking in a phosphorylation- and RAB5-dependent manner at steps upstream of autophagosome formation.
DOI: 10.7910/dvn/v1rjpf/uqbjux
title: ykc20160724_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/gnerkw
title: ykc20171003_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/rc7n5t
title: ykc20170724_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.3998448
title: A new Ginglymodi (Actinopterygii, Holostei) from the Late Jurassic–Early Cretaceous of Thailand, with comments on the early diversification of Lepisosteiformes in Southeast Asia

description: A new ginglymodian fish, <i>Khoratichthys gibbus</i>, gen. et sp. nov., is described based on the impression of a single articulated fish preserved on a sandstone slab from the Late Jurassic–Early Cretaceous Phu Kradung Formation, northeastern Thailand. <i>Khoratichthys gibbus</i> is characterized by a distinct humpbacked body with elongate posterior spines on the dorsal ridge scales; the cheek is completely covered by bone; it has few infraorbitals, the elongate anterior-most one shows a tiny contact with the orbit, and six suborbitals arranged in one row; the opercule is rectancular in shape; the preopercule is narrow and regularly curved; and the interopercule large. A cladistic analysis including the type species of 25 ginglymodian genera indicates that <i>Khoratichthys</i> is the basal-most Lepisosteiformes, in an unresolved position with <i>Neosemionotus</i> and <i>Lophionotus</i>. This taxon provides a new evidence of the high diversity of ginglymodian fishes in the Phu Kradung Formation. A high taxic diversity of ginglymodians in Middle Jurassic–Early Cretaceous of southern Asian (excluding India) freshwater environments is observed, indicating that this clade occupied a major position in freshwater fish assemblages. http://zoobank.org/urn:lsid:zoobank.org:pub:AE3056BF-0C4A-421F-B517-3A4BC777A3E1 SUPPLEMENTAL DATA—Supplemental materials are available for this article for free at www.tandfonline.com/UJVP Citation for this article: Deesri, U., P. Jintasakul, and L. Cavin. 2016. A new Ginglymodi (Actinopterygii, Holostei) from the Late Jurassic–Early Cretaceous of Thailand, with comments on the early diversification of Lepisosteiformes in Southeast Asia. Journal of Vertebrate Paleontology. DOI: 10.1080/02724634.2016.1225747.
DOI: 10.6084/m9.figshare.3998361
title: Exact <i>p</i>-Values for Network Interference

description: We study the calculation of exact <i>p</i>-values for a large class of nonsharp null hypotheses about treatment effects in a setting with data from experiments involving members of a single connected network. The class includes null hypotheses that limit the effect of one unit’s treatment status on another according to the distance between units, for example, the hypothesis might specify that the treatment status of immediate neighbors has no effect, or that units more than two edges away have no effect. We also consider hypotheses concerning the validity of sparsification of a network (e.g., based on the strength of ties) and hypotheses restricting heterogeneity in peer effects (so that, e.g., only the number or fraction treated among neighboring units matters). Our general approach is to define an artificial experiment, such that the null hypothesis that was not sharp for the original experiment is sharp for the artificial experiment, and such that the randomization analysis for the artificial experiment is validated by the design of the original experiment.
DOI: 10.6084/m9.figshare.3998448.v1
title: A new Ginglymodi (Actinopterygii, Holostei) from the Late Jurassic–Early Cretaceous of Thailand, with comments on the early diversification of Lepisosteiformes in Southeast Asia

description: A new ginglymodian fish, <i>Khoratichthys gibbus</i>, gen. et sp. nov., is described based on the impression of a single articulated fish preserved on a sandstone slab from the Late Jurassic–Early Cretaceous Phu Kradung Formation, northeastern Thailand. <i>Khoratichthys gibbus</i> is characterized by a distinct humpbacked body with elongate posterior spines on the dorsal ridge scales; the cheek is completely covered by bone; it has few infraorbitals, the elongate anterior-most one shows a tiny contact with the orbit, and six suborbitals arranged in one row; the opercule is rectancular in shape; the preopercule is narrow and regularly curved; and the interopercule large. A cladistic analysis including the type species of 25 ginglymodian genera indicates that <i>Khoratichthys</i> is the basal-most Lepisosteiformes, in an unresolved position with <i>Neosemionotus</i> and <i>Lophionotus</i>. This taxon provides a new evidence of the high diversity of ginglymodian fishes in the Phu Kradung Formation. A high taxic diversity of ginglymodians in Middle Jurassic–Early Cretaceous of southern Asian (excluding India) freshwater environments is observed, indicating that this clade occupied a major position in freshwater fish assemblages. http://zoobank.org/urn:lsid:zoobank.org:pub:AE3056BF-0C4A-421F-B517-3A4BC777A3E1 SUPPLEMENTAL DATA—Supplemental materials are available for this article for free at www.tandfonline.com/UJVP Citation for this article: Deesri, U., P. Jintasakul, and L. Cavin. 2016. A new Ginglymodi (Actinopterygii, Holostei) from the Late Jurassic–Early Cretaceous of Thailand, with comments on the early diversification of Lepisosteiformes in Southeast Asia. Journal of Vertebrate Paleontology. DOI: 10.1080/02724634.2016.1225747.
DOI: 10.7910/dvn/v1rjpf/caghv8
title: ykc20170318_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/gbrjuo
title: ykc20160222_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.3998361.v1
title: Exact P-values for Network Interference<sup>*, †</sup>

description: We study the calculation of exact p-values for a large class of non-sharp null hypotheses about treatment effects in a setting with data from experiments involving members of a single connected network. The class includes null hypotheses that limit the effect of one unit's treatment status on another according to the distance between units; for example, the hypothesis might specify that the treatment status of immediate neighbors has no effect, or that units more than two edges away have no effect. We also consider hypotheses concerning the validity of sparsification of a network (for example based on the strength of ties) and hypotheses restricting heterogeneity in peer effects (so that, for example, only the number or fraction treated among neighboring units matters). Our general approach is to define an artificial experiment, such that the null hypothesis that was not sharp for the original experiment is sharp for the artificial experiment, and such that the randomization analysis for the artificial experiment is validated by the design of the original experiment.
DOI: 10.7910/dvn/v1rjpf/wqt1kr
title: ykc20160319_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.3998361.v3
title: Exact <i>p</i>-Values for Network Interference

description: We study the calculation of exact <i>p</i>-values for a large class of nonsharp null hypotheses about treatment effects in a setting with data from experiments involving members of a single connected network. The class includes null hypotheses that limit the effect of one unit’s treatment status on another according to the distance between units, for example, the hypothesis might specify that the treatment status of immediate neighbors has no effect, or that units more than two edges away have no effect. We also consider hypotheses concerning the validity of sparsification of a network (e.g., based on the strength of ties) and hypotheses restricting heterogeneity in peer effects (so that, e.g., only the number or fraction treated among neighboring units matters). Our general approach is to define an artificial experiment, such that the null hypothesis that was not sharp for the original experiment is sharp for the artificial experiment, and such that the randomization analysis for the artificial experiment is validated by the design of the original experiment.
DOI: 10.7910/dvn/v1rjpf/i7ptly
title: ykc20171220_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.3998361.v2
title: Exact <i>p</i>-Values for Network Interference

description: We study the calculation of exact <i>p</i>-values for a large class of nonsharp null hypotheses about treatment effects in a setting with data from experiments involving members of a single connected network. The class includes null hypotheses that limit the effect of one unit’s treatment status on another according to the distance between units, for example, the hypothesis might specify that the treatment status of immediate neighbors has no effect, or that units more than two edges away have no effect. We also consider hypotheses concerning the validity of sparsification of a network (e.g., based on the strength of ties) and hypotheses restricting heterogeneity in peer effects (so that, e.g., only the number or fraction treated among neighboring units matters). Our general approach is to define an artificial experiment, such that the null hypothesis that was not sharp for the original experiment is sharp for the artificial experiment, and such that the randomization analysis for the artificial experiment is validated by the design of the original experiment.
DOI: 10.7910/dvn/v1rjpf/je5kwp
title: ykc20170123_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/nryauk
title: ykc20160912_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/qsgdrd
title: ykc20160521_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/lllduw
title: ykc20170227_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/nnf6cn
title: ykc20170512_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/s1fmy8
title: snk20160222_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.3997425
title: 6-Iodo-2-isopropyl-4<i>H</i>-3,1-benzoxazin-4-one as building block in heterocyclic synthesis

description: As a part of ongoing studies in the synthesis of a variety of heterocycles of biological importance, we report here an efficient and convenient method for the synthesis of novel compounds from 6-iodo-2-isopropyl-4<i>H</i>-3,1-benzoxazin-4-one <b>1</b> as building block. The reaction of benzoxazinone <b>1</b> with various reagents such as diethylmalonate, sodium azide, and phosphorus pentasulfide yielded the compounds <b>2–5</b>. The behavior of benzothiazin-4-thione <b>5</b> toward formamide and hydrazine hydrate was investigated, forming the compounds <b>6</b> and <b>7</b>. The reaction of quinazolinone derivative <b>8</b> with β-D-glucose pentaacetate, ethyl 2-methyl-5-((1S,2R,3R)-1,2,3,4-tetrahydroxybutyl)furan-3-carboxylate, epichlorohydrin and benzenesulphonyl chloride afforded quinazolinone derivatives <b>9, 10, 12,</b> and <b>13</b> respectively. The reaction of quinazolinone derivative <b>10</b> with acetic anhydride resulted in formation of the acylated compound <b>11</b>. The behavior of quinazolinylacetohydrazide derivative <b>14</b> toward carbon electrophiles<sup>[</sup><sup>16</sup><sup>]</sup> has been investigated by its reaction with ethyl benzoylacetate, potassium thiocyanate, and phenyl isothiocyanate, affording the quinazolinone derivatives <b>15, 16,</b> and <b>18</b>, respectively. Treatment of compound <b>16</b> with sodium hydroxide followed by hydrochloric acid yielded the mercapto-triazole derivative <b>17</b>. The structures of the newly synthesized compounds were confirmed by elemental analysis, infrared (IR), <sup>1</sup>H NMR, <sup>13</sup>C NMR, and mass spectra. The antimicrobial activities of some of the synthesized compounds were preliminarily evaluated.
DOI: 10.7910/dvn/v1rjpf/xiy5cv
title: snk20161227_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.3997425.v2
title: 6-Iodo-2-isopropyl-4<i>H</i>-3,1-benzoxazin-4-one as building block in heterocyclic synthesis

description: As a part of ongoing studies in the synthesis of a variety of heterocycles of biological importance, we report here an efficient and convenient method for the synthesis of novel compounds from 6-iodo-2-isopropyl-4<i>H</i>-3,1-benzoxazin-4-one <b>1</b> as building block. The reaction of benzoxazinone <b>1</b> with various reagents such as diethylmalonate, sodium azide, and phosphorus pentasulfide yielded the compounds <b>2–5</b>. The behavior of benzothiazin-4-thione <b>5</b> toward formamide and hydrazine hydrate was investigated, forming the compounds <b>6</b> and <b>7</b>. The reaction of quinazolinone derivative <b>8</b> with β-D-glucose pentaacetate, ethyl 2-methyl-5-((1S,2R,3R)-1,2,3,4-tetrahydroxybutyl)furan-3-carboxylate, epichlorohydrin and benzenesulphonyl chloride afforded quinazolinone derivatives <b>9, 10, 12,</b> and <b>13</b> respectively. The reaction of quinazolinone derivative <b>10</b> with acetic anhydride resulted in formation of the acylated compound <b>11</b>. The behavior of quinazolinylacetohydrazide derivative <b>14</b> toward carbon electrophiles<sup>[</sup><sup>16</sup><sup>]</sup> has been investigated by its reaction with ethyl benzoylacetate, potassium thiocyanate, and phenyl isothiocyanate, affording the quinazolinone derivatives <b>15, 16,</b> and <b>18</b>, respectively. Treatment of compound <b>16</b> with sodium hydroxide followed by hydrochloric acid yielded the mercapto-triazole derivative <b>17</b>. The structures of the newly synthesized compounds were confirmed by elemental analysis, infrared (IR), <sup>1</sup>H NMR, <sup>13</sup>C NMR, and mass spectra. The antimicrobial activities of some of the synthesized compounds were preliminarily evaluated.
DOI: 10.7910/dvn/v1rjpf/cki4od
title: snk20150312_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.3997425.v1
title: 6-Iodo-2-Isopropyl-4<i>H</i>-3,1-Benzoxazin-4-one as Building Block in Heterocyclic Synthesis

description: As a part of ongoing studies in the synthesis of a variety of heterocycles of biological importance, we report here an efficient and convenient method for the synthesis of novel compounds from 6-iodo-2-isopropyl-4<i>H</i>-3,1-benzoxazin-4-one <b>1</b> as building block. The reaction of benzoxazinone <b>1</b> with various reagents such as diethylmalonate, sodium azide and phosphorus pentasulfide yielded the compounds <b>2-5</b>. The behavior of benzothiazin-4-thione <b>5</b> towards formamide and hydrazine hydrate was investigated forming the compounds <b>6, 7</b>. The reaction of quinazolinone derivative <b>8</b> with β-D-glucose pentaacetate, ethyl 2-methyl-5-((1S,2 R,3 R)-1,2,3,4-tetrahydroxybutyl)furan-3-carboxylate, epichlorohydrin and benzenesulphonyl chloride afforded quinazolinone derivatives <b>9, 10, 12</b> and <b>13</b> respectively. The reaction of quinazolinone derivative <b>10</b> with acetic anhydride resulted in formation of the acylated compound <b>11</b>. The behavior of quinazolinylacetohydrazide derivative <b>14</b> towards carbon electrophiles<sup>[</sup><sup>16</sup><sup>]</sup> has been investigated by its reaction with ethyl benzoylacetate, potassium thiocyanate and phenyl isothiocyanate affording the quinazolinone derivatives <b>15, 16</b> and <b>18</b>, respectively. Treatment of compound <b>16</b> with sodium hydroxide followed by hydrochloric acid yielded the mercapto-triazole derivative <b>17</b>. The structures of the newly synthesized compounds were confirmed by elemental analysis, IR, <sup>1</sup>H NMR, <sup>13</sup>C NMR and mass spectra. The antimicrobial activities of some of the synthesized compounds were preliminarily evaluated.
DOI: 10.7910/dvn/v1rjpf/6vryei
title: snk20160917_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/0btgh9
title: snk20150306_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.3997251
title: Expression of kindlin-3 in melanoma cells impedes cell migration and metastasis

description: Kindlins are a small family of 4.1-ezrin-radixin-moesin (FERM)-containing cytoplasmic proteins. Kindlin-3 is expressed in platelets, hematopoietic cells, and endothelial cells. Kindlin-3 promotes integrin activation, clustering and outside-in signaling. Aberrant expression of kindlin-3 was reported in melanoma and breast cancer. Intriguingly, kindlin-3 has been reported to either positively or negatively regulate cancer cell metastasis. In this study, we sought to clarify the expression of kindlin-3 in melanoma cells and its role in melanoma metastasis. Two widely used metastatic mouse and human melanoma cell lines B16-F10 and M10, respectively, were examined and found to lack kindlin-3 mRNA and protein expression. When kindlin-3 was ectopically expressed in these cells, cell migration was markedly reduced. These are attributed to aberrant Rac1 and RhoA activation and overt membrane ruffling. Our data demonstrate for the first time that despite its well established role as a positive regulator of integrin-mediated cell adhesion, aberrant expression of kindlin-3 could lead to imbalanced RhoGTPases signaling that impedes rather than promotes cell migration.