cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.5096428.v1
title: Dataset for: Early life decline in neurogenesis markers and age-related changes of TrkB splice variant expression in the human subependymal zone

description: Neurogenesis in the subependymal zone (SEZ) declines across the human lifespan and reduced local neurotrophic support is speculated to be a contributing factor. While tyrosine receptor kinase B (TrkB) signalling is critical for neuronal differentiation, maturation and survival, little is known about subependymal TrkB expression changes during postnatal human life. In this study, we used quantitative PCR and in situ hybridisation to determine expression of the cell proliferation marker Ki67, the immature neuron marker doublecortin (DCX) and both full-length (TrkB-TK+) and truncated TrkB receptors (TrkB-TK-) in the human SEZ from infancy to middle age (n=26-35, 41 days–43 years). We further measured TrkB-TK+ and TrkB-TK- mRNAs in the SEZ from young adulthood into aging (n=50, 21-103 years), and related their transcript levels to neurogenic and glial cell markers. Ki67, DCX and both TrkB splice variant mRNAs significantly decreased in the SEZ from infancy to middle age. In contrast, TrkB-TK- mRNA increased in the SEZ from young adulthood into aging, whereas TrkB-TK+ mRNA remained stable. TrkB-TK- mRNA positively correlated with expression of neural precursor (glial fibrillary acidic protein delta and achaete-scute homolog 1) and glial cell markers (vimentin and pan glial fibrillary acidic protein). TrkB-TK+ mRNA positively correlated with expression of neuronal cell markers (DCX and tubulin beta 3 class III). Our results indicate that cells residing in the human SEZ maintain their responsiveness to neurotrophins; however, this capability may change across postnatal life. We suggest that TrkB splice variants may differentially influence neuronal and glial differentiation in the human SEZ.
DOI: 10.6084/m9.figshare.5096455.v1
title: MUSEC_Briefings_Archive

description: Archive of the MUSEC Briefings on educational and clinical interventions for children with developmental disorders. Debunking pseudoscience, and pointing the way to evidence-based interventions.<br>
DOI: 10.6084/m9.figshare.5096410
title: Profit & Loss Indicators for MOOC Triple-Bottom Line Reporting according to ISO 26000

description: The diagram suggests a number of indicators which can be used to measure the full costs and benefits of MOOC provision, using the ISO 26000 classification.<br>This is a first draft for feedback and consultation.
DOI: 10.6084/m9.figshare.5096410.v1
title: Profit & Loss Indicators for MOOC Triple-Bottom Line Reporting according to ISO 26000

description: The diagram suggests a number of indicators which can be used to measure the full costs and benefits of MOOC provision, using the ISO 26000 classification.<br>This is a first draft for feedback and consultation.
DOI: 10.6084/m9.figshare.5096392
title: Koala Project Sequence Raw Data

description: Raw 16s sequencing data from koala fecal material
DOI: 10.6084/m9.figshare.5092654
title: EEG Characterization of Subgroups of Children with Learning Disorders

description: Our objective was to determine if there were subgroups within a group of scholars with not otherwise specified learning disorders and if they had specific electroencephalographic patterns. Eighty-five subjects (31 female, 8-11 years) who scored low in at least two subscales -reading, writing and arithmetic- of the Infant Neuropsychological Evaluation were included. Electroencephalograms were recorded in 19 leads during rest with eyes closed; absolute power was obtained every 0.39 Hz. Three subgroups were formed according to children’s performance: Group 1 (G1, higher scores than Group 2 in reading speed and reading and writing accuracy), Group 2 (G2, better performance than G1 in composition) and Group 3 (G3, lower scores than Groups 1 and 2 in the three subscales). G3 had higher absolute power in frequencies in the delta and theta range at left frontotemporal sites than G1 and G2. G2 had higher absolute power within alpha frequencies than G3 and G1 at the left occipital site. G3 had higher absolute power in frequencies in the beta range than G1 in parietotemporal areas and than G2 in left frontopolar and temporal sites. G1 had higher absolute power within beta frequencies than G2 in the left frontopolar site. G3 had lower gamma absolute power values than the other groups in the left hemisphere, and gamma activity was higher in G1 than in G2 in frontopolar and temporal areas. This group of children with learning disorders is very heterogeneous. Three subgroups were found with different cognitive profiles, as well as a different electroencephalographic pattern. It is important to consider these differences when planning interventions for children with learning disorders.
DOI: 10.6084/m9.figshare.5092678
title: Gaining Historical and International Relations Insights from Social Media: Spatio-Temporal Real-World News Analysis using Twitter.

description: This dataset consists of metadata related to 24,508 news events, collected from Twitter spanning from August 2013 to June 2015. The events encompasses a total of 193,445,734 tweets produced by 26,127,624 different users.The files contain different aspects of the data.<br>- components.tsv consists of the description of the events (components) of our dataset, consisting of 4 columns separated by tabs. The columns correspond to the component ID, the date of an event, the amount of tweets and a set of keywords describing the event, separated by commas (having a minimum of 2).<br>- componentlocation.tsv consists of the description of the locations where the events happened (“protagonist locations”). The columns correspond to an ID, the component ID, the names of the locations, the frequency (how many times that location was mentioned in the component), the country code, and six more non-relevant columns. Note that one component can be in several rows, one per location being mentioned for that component.- country_protagonized-events.csv consists of the amount of events that one specific country is a protagonist of. It contains two columns, separated by comma, being the first the country code and the second the amount of events (components) that country is a protagonist of.<br>- country_tweets.csv consists of the amount of tweets that one specific country has issued along all the events. It contains two columns, separated by comma, being the first the country code and the second the amount of tweets that country has issued.- participation_data.txt contains a matrix indicating the amount of tweets per country, per event. It contains one row per component ID, and one column per country (plus one column for the component ID); the cell value is the amount of tweets that country has issued for that event.<br>- similarities_no_reciproco_percentile.csv corresponds to the similarity between co-protagonist countries. The columns are in the following order: Country 1, the amount of events Country 1 is a protagonist of, Country 2, the amount of events Country 2 is a protagonist of, the Jaccard Similarity between the two countries (where the country is represented by the set of the component IDs that country is a protagonist of), and the percentile of that similarity value (ranging from 0 to 1).- users_events_distinct.txt corresponds to the amount of unique users participating in an event. The columns are separated by tabs. The first columns is the component ID, the second is the amount of different users for that event, and the third is the amount of of different news sources for that event.- countries.txt is the mapping between country code and country name, separated by space.
DOI: 10.6084/m9.figshare.5092654.v1
title: EEG Characterization of Subgroups of Children with Learning Disorders

description: Our objective was to determine if there were subgroups within a group of scholars with not otherwise specified learning disorders and if they had specific electroencephalographic patterns. Eighty-five subjects (31 female, 8-11 years) who scored low in at least two subscales -reading, writing and arithmetic- of the Infant Neuropsychological Evaluation were included. Electroencephalograms were recorded in 19 leads during rest with eyes closed; absolute power was obtained every 0.39 Hz. Three subgroups were formed according to children’s performance: Group 1 (G1, higher scores than Group 2 in reading speed and reading and writing accuracy), Group 2 (G2, better performance than G1 in composition) and Group 3 (G3, lower scores than Groups 1 and 2 in the three subscales). G3 had higher absolute power in frequencies in the delta and theta range at left frontotemporal sites than G1 and G2. G2 had higher absolute power within alpha frequencies than G3 and G1 at the left occipital site. G3 had higher absolute power in frequencies in the beta range than G1 in parietotemporal areas and than G2 in left frontopolar and temporal sites. G1 had higher absolute power within beta frequencies than G2 in the left frontopolar site. G3 had lower gamma absolute power values than the other groups in the left hemisphere, and gamma activity was higher in G1 than in G2 in frontopolar and temporal areas. This group of children with learning disorders is very heterogeneous. Three subgroups were found with different cognitive profiles, as well as a different electroencephalographic pattern. It is important to consider these differences when planning interventions for children with learning disorders.
DOI: 10.6084/m9.figshare.5092534
title: The <i>p53</i> R72P polymorphism does not affect the physiological response to ionizing radiation in a mouse model

description: Tissue culture and mouse model studies show that the presence of the arginine (R) or proline (P) coding single nucleotide polymorphism (SNP) of the tumor suppressor gene <i>p53</i> at codon 72 (<i>p53</i> R72P) differentially affects the responses to genotoxic insult. Compared to the P variant, the R variant shows increased apoptosis in most cell cultures and mouse model tissues in response to genotoxins, and epidemiological studies suggest that the R variant may enhance cancer survival and reduce the risks of adverse reactions to genotoxic cancer treatment. As ionizing radiation (IR) treatment is often used in cancer therapy, we sought to test the physiological effects of IR in mouse models of the <i>p53</i> R72P polymorphism. By performing blood counts, immunohistochemical (IHC) staining and survival studies in mouse populations rigorously controlled for strain background, sex and age, we discovered that <i>p53</i> R72P polymorphism <i>did not</i> differentially affect the physiological response to IR. Our findings suggest that genotyping for this polymorphism to personalize IR therapy may have little clinical utility.
DOI: 10.6084/m9.figshare.5092531
title: Advanced phases and reduced amplitudes are suggested to characterize the daily rest-activity cycles in depressed adolescent boys

description: Self-reported eveningness has been previously associated with depressed mood among adults and adolescents. Here, we study how circadian indicators based on actigraphic data differ between depressed and healthy adolescent boys. Our sample consisted of 17 medication-free adolescent boys, aged 14.5 to 17.5 years, of which eight had depressive disorder and were currently depressed and nine were healthy comparison participants. Psychiatric assessment was conducted by diagnostic interviews and complemented with observer-rating and self-rating scales. Actigraphic data were collected with wrist actigraphs for a minimum period of 25 consecutive days (range of 25 to 44 days). The behavioral trait of morningness–eveningness was measured with the 19-item Horne-Östberg Morningness–Eveningness Questionnaire. Based on the self-report, the depressed boys were more prone to eveningness than healthy controls, but based on the actigraphic data, they had earlier phases especially on school days and lower activity levels especially on weekends. On weekends, the depressed boys showed a greater shift toward later-timed phases than healthy controls. Our results confirm a mismatch of the subjective morningness–eveningness preference (late-preference) and the objective rest-activity rhythm (early-prone) during school days in depressed adolescent boys.
DOI: 10.6084/m9.figshare.5092534.v1
title: The <i>p53</i> R72P polymorphism does not affect the physiological response to ionizing radiation in a mouse model

description: Tissue culture and mouse model studies show that the presence of the arginine (R) or proline (P) coding single nucleotide polymorphism (SNP) of the tumor suppressor gene <i>p53</i> at codon 72 (<i>p53</i> R72P) differentially affects the responses to genotoxic insult. Compared to the P variant, the R variant shows increased apoptosis in most cell cultures and mouse model tissues in response to genotoxins, and epidemiological studies suggest that the R variant may enhance cancer survival and reduce the risks of adverse reactions to genotoxic cancer treatment. As ionizing radiation (IR) treatment is often used in cancer therapy, we sought to test the physiological effects of IR in mouse models of the <i>p53</i> R72P polymorphism. By performing blood counts, immunohistochemical (IHC) staining and survival studies in mouse populations rigorously controlled for strain background, sex and age, we discovered that <i>p53</i> R72P polymorphism <i>did not</i> differentially affect the physiological response to IR. Our findings suggest that genotyping for this polymorphism to personalize IR therapy may have little clinical utility.
DOI: 10.6084/m9.figshare.5092531.v1
title: Advanced phases and reduced amplitudes are suggested to characterize the daily rest-activity cycles in depressed adolescent boys

description: Self-reported eveningness has been previously associated with depressed mood among adults and adolescents. Here, we study how circadian indicators based on actigraphic data differ between depressed and healthy adolescent boys. Our sample consisted of 17 medication-free adolescent boys, aged 14.5 to 17.5 years, of which eight had depressive disorder and were currently depressed and nine were healthy comparison participants. Psychiatric assessment was conducted by diagnostic interviews and complemented with observer-rating and self-rating scales. Actigraphic data were collected with wrist actigraphs for a minimum period of 25 consecutive days (range of 25 to 44 days). The behavioral trait of morningness–eveningness was measured with the 19-item Horne-Östberg Morningness–Eveningness Questionnaire. Based on the self-report, the depressed boys were more prone to eveningness than healthy controls, but based on the actigraphic data, they had earlier phases especially on school days and lower activity levels especially on weekends. On weekends, the depressed boys showed a greater shift toward later-timed phases than healthy controls. Our results confirm a mismatch of the subjective morningness–eveningness preference (late-preference) and the objective rest-activity rhythm (early-prone) during school days in depressed adolescent boys.
DOI: 10.6084/m9.figshare.5092483
title: scikit-learn financial historical quotes

description: The data used in the scikit-learn stock market example
DOI: 10.6084/m9.figshare.5092483.v1
title: scikit-learn financial historical quotes

description: The data used in the scikit-learn stock market example
DOI: 10.6084/m9.figshare.5092411
title: Cultural echoes in Dutch immigrants’ and non-immigrants’ understandings and values of nature

description: Contemporary societies are rapidly changing demographically and culturally. This raises new challenges regarding support for and engagement in nature conservation. Our paper discusses differences and similarities between young adult non-immigrants and immigrants in how they understand and value nature, based on group interviews and a survey conducted among young adults of Turkish, Chinese and non-immigrant Dutch backgrounds. We show that how people perceive nature differs between ethnic groups, even though the immigrants included spent (most of) their youth in the Netherlands. Non-immigrants used most strict boundaries to qualify green areas as nature, while especially Chinese immigrants expressed a more inclusive idea of nature. Turkish immigrants articulated most often ecocentric and religious reasons to conserve nature, while Chinese immigrants stood out as mentioning most often anthropocentric reasons. Traditional cultural representations of nature partly seemed to echo in people's perceptions of nature. Support for nature conservation was high among the respondents; however, this hardly translated into engagement in nature conservation.
DOI: 10.6084/m9.figshare.5092414
title: cp_whole.nex

description: whole cp gonome matrix for the phylogenetic tree reconstruction
DOI: 10.6084/m9.figshare.5092420
title: CDS.fas.nex

description: CDs matrix for the phylogenetic tree reconstruction
DOI: 10.6084/m9.figshare.5092414.v1
title: cp_whole.nex

description: whole cp gonome matrix for the phylogenetic tree reconstruction
DOI: 10.6084/m9.figshare.5092420.v1
title: CDS.fas.nex

description: CDs matrix for the phylogenetic tree reconstruction
DOI: 10.6084/m9.figshare.5092411.v1
title: Cultural echoes in Dutch immigrants’ and non-immigrants’ understandings and values of nature

description: Contemporary societies are rapidly changing demographically and culturally. This raises new challenges regarding support for and engagement in nature conservation. Our paper discusses differences and similarities between young adult non-immigrants and immigrants in how they understand and value nature, based on group interviews and a survey conducted among young adults of Turkish, Chinese and non-immigrant Dutch backgrounds. We show that how people perceive nature differs between ethnic groups, even though the immigrants included spent (most of) their youth in the Netherlands. Non-immigrants used most strict boundaries to qualify green areas as nature, while especially Chinese immigrants expressed a more inclusive idea of nature. Turkish immigrants articulated most often ecocentric and religious reasons to conserve nature, while Chinese immigrants stood out as mentioning most often anthropocentric reasons. Traditional cultural representations of nature partly seemed to echo in people's perceptions of nature. Support for nature conservation was high among the respondents; however, this hardly translated into engagement in nature conservation.
DOI: 10.6084/m9.figshare.5092351
title: Synthesis and antimicrobial evaluation of some novel dithiolane, thiophene, coumarin, and 2-pyridone derivatives

description: Novel 2-cyano-<i>N</i>-[1-(naphtha-2-yl)ethylidene] acetohydrazide <b>1</b> was utilized as key intermediate for the synthesis of some new dithiolane, thiophene, coumarin, 2-pyridone, and other related products containing a hydrazide moiety. Newly synthesized compounds were characterized by elemental analyses and spectral data (IR, <sup>1</sup>H NMR and mass spectra). The antimicrobial activity of the synthesized compounds was evaluated.
DOI: 10.6084/m9.figshare.5092351.v1
title: Synthesis and Antimicrobial Evaluation of Some Novel Dithiolane, Thiophene, Coumarin and 2-pyridone Derivatives

description: Novel 2-cyano-<i>N</i>-[1-(naphtha-2-yl)ethylidene] acetohydrazide <b>1</b> was utilized as key intermediate for the synthesis of some new dithiolane, thiophene, coumarin, 2-pyridone, and other related products containing a hydrazide moiety. Newly synthesized compounds were characterized by elemental analyses and spectral data (IR, <sup>1</sup>H NMR, <sup>13</sup>C NMR and mass spectra). The antimicrobial activity of the synthesized compounds was evaluated.
DOI: 10.6084/m9.figshare.5092312.v2
title: Thermoresponsive nanocomposite gel for local drug delivery to suppress the growth of glioma by inducing autophagy

description: Although the treatments of malignant glioma include surgery, radiotherapy and chemotherapy by oral drug administration, the prognosis of patients with glioma remains very poor. We developed a polyethylene glycol-dipalmitoylphosphatidyle- thanoiamine (mPEG-DPPE) calcium phosphate nanoparticles (NPs) injectable thermoresponsive hydrogel (nanocomposite gel) that could provide a sustained and local delivery of paclitaxel (PTX) and temozolomide (TMZ). In addition, the proportion of PTX and TMZ for the optimal synergistic antiglioma effect on C6 cells was determined to be 1:100 (w/w) by the Chou and Talalay method. Our results clearly indicated that the autophagy induced by PTX:TMZ NPs plays an important role in regulating tumor cell death, while autophagy inhibition dramatically reverses the antitumor effect of PTX:TMZ NPs, suggesting that antiproliferative autophagy occurs in response to PTX:TMZ NPs treatment. The antitumor efficacy of the PTX:TMZ NP-loaded gel was evaluated in situ using C6 tumor-bearing rats, and the PTX:TMZ NP-loaded gel exhibited superior antitumor performance. The antitumor effects of the nanocomposite gel in vivo were shown to correlate with autophagic cell death in this study. The in vivo results further confirmed the advantages of such a strategy. The present study may provide evidence supporting the development of nanomedicine for potential clinical application.
DOI: 10.6084/m9.figshare.5092237
title: Vascular plant species records for La Amistad National Park, Costa Rica & Panama

description: An excel spreadsheet of vascular plant species documented in La Amistad National Park including cited including APG3 family, specimen data, global distribution, elevation range and lifezone.
DOI: 10.6084/m9.figshare.5092237.v1
title: Vascular plant species records for La Amistad National Park, Costa Rica & Panama

description: An excel spreadsheet of vascular plant species documented in La Amistad National Park including cited including APG3 family, specimen data, global distribution, elevation range and lifezone.
DOI: 10.6084/m9.figshare.5092312.v1
title: Thermoresponsive Nanocomposite Gel for Local Drug Delivery to Suppress the Growth of Glioma by Inducing Autophagy

description: Although the treatments of malignant glioma include surgery, radiotherapy and chemotherapy by oral drug administration, the prognosis of patients with glioma remains very poor. We developed a polyethylene glycol-dipalmitoylphosphatidyle- thanoiamine (mPEG-DPPE) calcium phosphate nanoparticles (NPs) injectable thermoresponsive hydrogel (nanocomposite gel) that could provide a sustained and local delivery of paclitaxel (PTX) and temozolomide (TMZ). In addition, the proportion of PTX and TMZ for the optimal synergistic antiglioma effect on C6 cells was determined to be 1:100 (w/w) by the Chou and Talalay method. Our results clearly indicated that the autophagy induced by PTX:TMZ NPs plays an important role in regulating tumor cell death, while autophagy inhibition dramatically reverses the antitumor effect of PTX:TMZ NPs, suggesting that antiproliferative autophagy occurs in response to PTX:TMZ NPs treatment. The antitumor efficacy of the PTX:TMZ NP-loaded gel was evaluated in situ using C6 tumor-bearing rats, and the PTX:TMZ NP-loaded gel exhibited superior antitumor performance. The antitumor effects of the nanocomposite gel in vivo were shown to correlate with autophagic cell death in this study. The in vivo results further confirmed the advantages of such a strategy. The present study may provide evidence supporting the development of nanomedicine for potential clinical application.