cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.20014989
title: Implicações da prática musical no processamento auditivo central: uma revisão sistemática

description: Resumo Introdução: Estudos recentes evidenciaram que a prática e o treinamento musical mostram-se eficazes e com potencialidades para auxiliar na aquisição e no aprimoramento das habilidades auditivas. Objetivo: Verificar as evidências científicas sobre as implicações da prática musical no processamento auditivo central. Método: Foi feita uma revisão sistemática conduzida conforme as recomendações do Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) e foram usadas as bases de dados Medline (Pubmed), Lilacs, SciELO, Bireme, Scopus, Web of Science. O período de busca dos artigos compreendeu os últimos 5 anos (2015 a 2020), sem restrição de idioma e localização. Foi feita avaliação da qualidade dos artigos, na qual se incluía artigos com nota mínima 6 em escala de qualidade modificada da literatura. Resultados: Inicialmente foram encontradas 1.362 publicações, das quais 1.338 foram excluídas na triagem do título, 15 excluídas pelo resumo, foram nove artigos analisados na íntegra e quatro deles excluídos após análise, pois não responderam à pergunta norteadora proposta para esta pesquisa. Foram admitidos para esta pesquisa cinco artigos que atendiam os critérios de inclusão propostos. Constatou-se que nos adultos a habilidade musical está associada ao melhor desempenho de várias habilidades do processamento auditivo, bem como o treinamento musical em crianças promoveu uma maturidade acelerada do processamento auditivo e a exposição à música facilitou o aprendizado das informações auditivas nos recém-nascidos. Conclusão: Considerando as evidências científicas, constatou-se que a experiência musical pode aprimorar habilidades específicas do processamento auditivo central, independentemente da idade, o que aprimora o desenvolvimento linguístico das crianças.
DOI: 10.6084/m9.figshare.20014989.v1
title: Implicações da prática musical no processamento auditivo central: uma revisão sistemática

description: Resumo Introdução: Estudos recentes evidenciaram que a prática e o treinamento musical mostram-se eficazes e com potencialidades para auxiliar na aquisição e no aprimoramento das habilidades auditivas. Objetivo: Verificar as evidências científicas sobre as implicações da prática musical no processamento auditivo central. Método: Foi feita uma revisão sistemática conduzida conforme as recomendações do Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) e foram usadas as bases de dados Medline (Pubmed), Lilacs, SciELO, Bireme, Scopus, Web of Science. O período de busca dos artigos compreendeu os últimos 5 anos (2015 a 2020), sem restrição de idioma e localização. Foi feita avaliação da qualidade dos artigos, na qual se incluía artigos com nota mínima 6 em escala de qualidade modificada da literatura. Resultados: Inicialmente foram encontradas 1.362 publicações, das quais 1.338 foram excluídas na triagem do título, 15 excluídas pelo resumo, foram nove artigos analisados na íntegra e quatro deles excluídos após análise, pois não responderam à pergunta norteadora proposta para esta pesquisa. Foram admitidos para esta pesquisa cinco artigos que atendiam os critérios de inclusão propostos. Constatou-se que nos adultos a habilidade musical está associada ao melhor desempenho de várias habilidades do processamento auditivo, bem como o treinamento musical em crianças promoveu uma maturidade acelerada do processamento auditivo e a exposição à música facilitou o aprendizado das informações auditivas nos recém-nascidos. Conclusão: Considerando as evidências científicas, constatou-se que a experiência musical pode aprimorar habilidades específicas do processamento auditivo central, independentemente da idade, o que aprimora o desenvolvimento linguístico das crianças.
DOI: 10.6084/m9.figshare.20014991
title: Dipirona na analgesia preventiva pós-operatória de tonsilectomia em crianças: revisão sistemática

description: Resumo Introdução: A tonsilectomia é a 2ª cirurgia ambulatorial mais comum feita em crianças nos Estados Unidos da América. Sua principal complicação é a dor, cuja intensidade varia de moderada a intensa. A dipirona é um dos analgésicos mais usados no pós-operatório em crianças. Seu uso, entretanto, é controverso na literatura, a ponto de ser proibido em vários países devido aos seus potenciais efeitos adversos graves. Por causa dessa controvérsia, revisar o uso da dipirona como analgésico no pós-operatório de tonsilectomia em crianças é fundamental. Objetivo: Revisar o uso analgésico da dipirona no pós-operatório de tonsilectomia em crianças. Método: Revisão sistemática da literatura, envolveu a avaliação da qualidade dos artigos nas bases de dados Medline/Pubmed, Embase e Virtual Health Library, selecionados com estratégia de busca pré-estabelecida. Foram incluídos apenas estudos com desenho de ensaio clínico randomizado que avaliassem o uso de dipirona no pós-operatório de tonsilectomia em crianças. Resultados e conclusão: Foram encontrados apenas 2 ensaios clínicos randomizados. Ambos compararam dipirona, paracetamol e placebo. Não foi possível fazer a metanálise porque os estudos eram muito heterogêneos (dipirona foi usada como analgésico preventivo em um estudo e somente no pós-operatório em outro). O efeito analgésico da dipirona, medido através de escalas de dor validadas na infância, mostrou-se superior ao placebo e semelhante ao paracetamol. Parece que a dipirona apresenta um perfil adequado para uso em crianças. Entretanto, a escassez de ensaios clínicos randomizados que avaliem seu efeito analgésico nessa faixa etária leva à conclusão de que estudos mais bem delineados ainda são necessários para estabelecer o papel da dipirona no pós-operatório de tonsilectomia em crianças.
DOI: 10.6084/m9.figshare.20014991.v1
title: Dipirona na analgesia preventiva pós-operatória de tonsilectomia em crianças: revisão sistemática

description: Resumo Introdução: A tonsilectomia é a 2ª cirurgia ambulatorial mais comum feita em crianças nos Estados Unidos da América. Sua principal complicação é a dor, cuja intensidade varia de moderada a intensa. A dipirona é um dos analgésicos mais usados no pós-operatório em crianças. Seu uso, entretanto, é controverso na literatura, a ponto de ser proibido em vários países devido aos seus potenciais efeitos adversos graves. Por causa dessa controvérsia, revisar o uso da dipirona como analgésico no pós-operatório de tonsilectomia em crianças é fundamental. Objetivo: Revisar o uso analgésico da dipirona no pós-operatório de tonsilectomia em crianças. Método: Revisão sistemática da literatura, envolveu a avaliação da qualidade dos artigos nas bases de dados Medline/Pubmed, Embase e Virtual Health Library, selecionados com estratégia de busca pré-estabelecida. Foram incluídos apenas estudos com desenho de ensaio clínico randomizado que avaliassem o uso de dipirona no pós-operatório de tonsilectomia em crianças. Resultados e conclusão: Foram encontrados apenas 2 ensaios clínicos randomizados. Ambos compararam dipirona, paracetamol e placebo. Não foi possível fazer a metanálise porque os estudos eram muito heterogêneos (dipirona foi usada como analgésico preventivo em um estudo e somente no pós-operatório em outro). O efeito analgésico da dipirona, medido através de escalas de dor validadas na infância, mostrou-se superior ao placebo e semelhante ao paracetamol. Parece que a dipirona apresenta um perfil adequado para uso em crianças. Entretanto, a escassez de ensaios clínicos randomizados que avaliem seu efeito analgésico nessa faixa etária leva à conclusão de que estudos mais bem delineados ainda são necessários para estabelecer o papel da dipirona no pós-operatório de tonsilectomia em crianças.
DOI: 10.6084/m9.figshare.20015000
title: Impact of auditory feedback alterations in individuals with stuttering

description: Abstract Introduction Electrophysiological evidence has reinforced the hypothesis that stuttering is associated with a deficit in modulation of the cortical auditory system during speech planning, contributing to an inefficient auditory feedback monitoring and, consequently, resulting in disfluencies. Objective To verify the impact of auditory feedback modifications on the spontaneous speech of individuals with stuttering. Methods Sixteen individuals, of both genders, aged 8-17 years and 11 months, with a diagnosis of persistent neurodevelopmental stuttering, were divided into two groups: Moderate Stuttering Group and Severe Stuttering Group. The testing procedures consisted of three stages: collection of identification data, audiological assessment and fluency evaluation of spontaneous speech in four auditory feedback conditions (non-altered, delayed, masked and amplified). The speech sample obtained in the non-altered feedback was considered the control; the others were considered as modified listening conditions. Results Regarding the stuttering-like disfluencies, a statistically significant difference was observed in the intragroup analysis of the Moderate Stuttering Group between non-altered and masked auditory feedback (p = 0.042), as well as between non-altered and amplified (p = 0.042). There was a statistically significant difference in the Severe Stuttering Group for all auditory feedback modifications in relation to the non-altered (delayed p = 0.012, masked p = 0.025 and amplified p = 0.042). There was also a reduction in flows of syllables and words-per-minute in the Moderate Stuttering Group for the delayed auditory feedback, as compared to non-altered (p = 0.017 and p = 0.025, respectively). Conclusion The effect of delayed auditory feedback was favorable for the Severe Stuttering Group, promoting speech fluency. The conditions of masked and amplified auditory feedback resulted in speech benefits in both groups, decreasing the number of stuttering-like disfluencies. The speech rate was not impaired by any listening condition analyzed.
DOI: 10.6084/m9.figshare.20015000.v1
title: Impact of auditory feedback alterations in individuals with stuttering

description: Abstract Introduction Electrophysiological evidence has reinforced the hypothesis that stuttering is associated with a deficit in modulation of the cortical auditory system during speech planning, contributing to an inefficient auditory feedback monitoring and, consequently, resulting in disfluencies. Objective To verify the impact of auditory feedback modifications on the spontaneous speech of individuals with stuttering. Methods Sixteen individuals, of both genders, aged 8-17 years and 11 months, with a diagnosis of persistent neurodevelopmental stuttering, were divided into two groups: Moderate Stuttering Group and Severe Stuttering Group. The testing procedures consisted of three stages: collection of identification data, audiological assessment and fluency evaluation of spontaneous speech in four auditory feedback conditions (non-altered, delayed, masked and amplified). The speech sample obtained in the non-altered feedback was considered the control; the others were considered as modified listening conditions. Results Regarding the stuttering-like disfluencies, a statistically significant difference was observed in the intragroup analysis of the Moderate Stuttering Group between non-altered and masked auditory feedback (p = 0.042), as well as between non-altered and amplified (p = 0.042). There was a statistically significant difference in the Severe Stuttering Group for all auditory feedback modifications in relation to the non-altered (delayed p = 0.012, masked p = 0.025 and amplified p = 0.042). There was also a reduction in flows of syllables and words-per-minute in the Moderate Stuttering Group for the delayed auditory feedback, as compared to non-altered (p = 0.017 and p = 0.025, respectively). Conclusion The effect of delayed auditory feedback was favorable for the Severe Stuttering Group, promoting speech fluency. The conditions of masked and amplified auditory feedback resulted in speech benefits in both groups, decreasing the number of stuttering-like disfluencies. The speech rate was not impaired by any listening condition analyzed.
DOI: 10.6084/m9.figshare.20015001
title: The efficacy of esmolol, remifentanil and nitroglycerin in controlled hypotension for functional endoscopic sinus surgery

description: Abstract Introduction Controlled hypotension is a reversible procedure in which the patient’s baseline mean arterial blood pressure is reduced by 30% and sustained at 60-70 mmHg during the procedure. It decreases blood loss and provides clear surgical field during the procedures. Objectives The purpose of this study was to compare the efficacy of controlled hypotension agents esmolol, remifentanil, and nitroglycerin in functional endoscopic sinus surgery, in terms of hemodynamic changes and impact on the surgical efficiency. Methods The research was carried out as a cohort study. Patients who underwent functional endoscopic sinus surgery were randomized into 3 groups. Controlled hypotension was achieved with remifentanil (Group R), esmolol (Group E) and nitroglycerin (Group N). The efficacy of the drugs was tested by comparing the length of time with the targeted mean arterial pressure, the amount of anesthetics used, surgical field bleeding score and surgeon’s satisfaction. Results Between May to December 2015, 60 patients were included and randomized equally into 3 different study groups. The median of the length of time with the targeted mean arterial pressure was shorter in the Group R when compared with Group E (p = 0.01) and Group N (p = 0.14). The amount of volatile anesthetics used was 25.0 mL (15-51), 43.0 mL (21-105) and 40.0 mL (26-97) in Groups R, E and N, respectively (p &lt; 0.001). While there was more bleeding with nitroglycerin, surgical field bleeding scores were lower in Group R when compared with esmolol (p = 0.001) and nitroglycerin (p &lt; 0.001). The analysis of surgeon’s satisfaction scores concluded that surgeons were more satisfied with the group R (100%), when compared with group E (60%) and group N (30%) (p &lt; 0.001). Conclusion Less volatile agent, short time to achieve controlled hypotension, stable blood pressure, lower surgical field bleeding scores and larger length of time with the targeted mean arterial pressure were found as the advantages of Remifentanil. Less costly, efficiency of achieving the targeted median arterial pressure and less postoperative complications were the advantages of nitroglycerin. In functional endoscopic sinus surgery procedures, appropriate controlled hypotensive agents should be selected according to the patients’ characteristics and advantages/disadvantages of the drugs.
DOI: 10.6084/m9.figshare.20015001.v1
title: The efficacy of esmolol, remifentanil and nitroglycerin in controlled hypotension for functional endoscopic sinus surgery

description: Abstract Introduction Controlled hypotension is a reversible procedure in which the patient’s baseline mean arterial blood pressure is reduced by 30% and sustained at 60-70 mmHg during the procedure. It decreases blood loss and provides clear surgical field during the procedures. Objectives The purpose of this study was to compare the efficacy of controlled hypotension agents esmolol, remifentanil, and nitroglycerin in functional endoscopic sinus surgery, in terms of hemodynamic changes and impact on the surgical efficiency. Methods The research was carried out as a cohort study. Patients who underwent functional endoscopic sinus surgery were randomized into 3 groups. Controlled hypotension was achieved with remifentanil (Group R), esmolol (Group E) and nitroglycerin (Group N). The efficacy of the drugs was tested by comparing the length of time with the targeted mean arterial pressure, the amount of anesthetics used, surgical field bleeding score and surgeon’s satisfaction. Results Between May to December 2015, 60 patients were included and randomized equally into 3 different study groups. The median of the length of time with the targeted mean arterial pressure was shorter in the Group R when compared with Group E (p = 0.01) and Group N (p = 0.14). The amount of volatile anesthetics used was 25.0 mL (15-51), 43.0 mL (21-105) and 40.0 mL (26-97) in Groups R, E and N, respectively (p &lt; 0.001). While there was more bleeding with nitroglycerin, surgical field bleeding scores were lower in Group R when compared with esmolol (p = 0.001) and nitroglycerin (p &lt; 0.001). The analysis of surgeon’s satisfaction scores concluded that surgeons were more satisfied with the group R (100%), when compared with group E (60%) and group N (30%) (p &lt; 0.001). Conclusion Less volatile agent, short time to achieve controlled hypotension, stable blood pressure, lower surgical field bleeding scores and larger length of time with the targeted mean arterial pressure were found as the advantages of Remifentanil. Less costly, efficiency of achieving the targeted median arterial pressure and less postoperative complications were the advantages of nitroglycerin. In functional endoscopic sinus surgery procedures, appropriate controlled hypotensive agents should be selected according to the patients’ characteristics and advantages/disadvantages of the drugs.
DOI: 10.5281/zenodo.6619615
title: Convergence in phosphorus constraints to photosynthesis dataset - modelling results

description: The archive contains the extract of model results shown in the publication 'Convergence in phosphorus constraints to photosynthesis' by David Ellsworth et al. in Nature Communication. README: # Simulation results from ORCHIDEE LSM v1.2 (https://doi.org/10.14768/20200407002.1)<br> # time period: 1992-2021<br> # author: Daniel Goll (dsgoll123@gmail.com) # the following variables are found in these files:<br> # GPP [g/m2/yr] -&gt; gpp.nc<br> # POTENTIAL GPP (assuming maximum P content) [g/m2/yr] -&gt; gpp_pot_max.nc<br> # POTENTIAL GPP (assuming average P content) [g/m2/yr] -&gt; gpp_pot_avg.nc<br> # LEAF N:P RATIO [g/g] -&gt; leafNP.nc
DOI: 10.5281/zenodo.6619614
title: Convergence in phosphorus constraints to photosynthesis dataset - modelling results

description: The archive contains the extract of model results shown in the publication 'Convergence in phosphorus constraints to photosynthesis' by David Ellsworth et al. in Nature Communication. README: # Simulation results from ORCHIDEE LSM v1.2 (https://doi.org/10.14768/20200407002.1)<br> # time period: 1992-2021<br> # author: Daniel Goll (dsgoll123@gmail.com) # the following variables are found in these files:<br> # GPP [g/m2/yr] -&gt; gpp.nc<br> # POTENTIAL GPP (assuming maximum P content) [g/m2/yr] -&gt; gpp_pot_max.nc<br> # POTENTIAL GPP (assuming average P content) [g/m2/yr] -&gt; gpp_pot_avg.nc<br> # LEAF N:P RATIO [g/g] -&gt; leafNP.nc
DOI: 10.6084/m9.figshare.19898036
title: Interferon-α action in cytokine profile in eosinophilic nasal polyp cultures

description: Abstract Introduction Chronic rhinosinusitis is currently classified into two types: chronic rhinosinusitis without nasal polyps and chronic rhinosinusitis with nasal polyps. In the West, approximately 80% of chronic rhinosinusitis with nasal polyps cases are characterized by a predominantly eosinophilic cell infiltrate and a Th2 cytokine pattern. Objective To evaluate the effect of Interferon-α on cytokine levels of the eosinophilic nasal polyp cell culture supernatant. Methods Cell cultures were performed based on nasal polypoid tissue samples collected from 13 patients with eosinophilic chronic rhinosinusitis with nasal polyps. Polyps were considered eosinophilic according to the histopathological examination. Cell cultures were stimulated with 3000 IU of interferon-α. Before and after the stimulus, concentrations of Interferon-γ, tumor necrosis factor αand IL 2, 4, 6 and 10, using cytometric bead array, were assessed. Results Cell samples from eosinophilic nasal polyps from 13 patients were included in the study. Twenty-four hours after interferon-α stimulation, eosinophilic nasal polyp culture supernatants showed significantly decreased IL-4 concentrations and increase in interferon-γ, IL-10 and IL-6 concentrations compared to controls. There were no significant differences in tumor necrosis factor -α and IL-2 concentrations. Conclusion We demonstrated that interferon-α in vitro alters the pattern of cytokines in cell cultures of eosinophilic nasal polyps. Analysis of these alterations suggests that interferon-α promotes a rebalancing of inflammatory profiles in cell cultures, favoring the expression of Th1 and regulatory cytokines over Th2 cytokines.
DOI: 10.6084/m9.figshare.19898036.v1
title: Interferon-α action in cytokine profile in eosinophilic nasal polyp cultures

description: Abstract Introduction Chronic rhinosinusitis is currently classified into two types: chronic rhinosinusitis without nasal polyps and chronic rhinosinusitis with nasal polyps. In the West, approximately 80% of chronic rhinosinusitis with nasal polyps cases are characterized by a predominantly eosinophilic cell infiltrate and a Th2 cytokine pattern. Objective To evaluate the effect of Interferon-α on cytokine levels of the eosinophilic nasal polyp cell culture supernatant. Methods Cell cultures were performed based on nasal polypoid tissue samples collected from 13 patients with eosinophilic chronic rhinosinusitis with nasal polyps. Polyps were considered eosinophilic according to the histopathological examination. Cell cultures were stimulated with 3000 IU of interferon-α. Before and after the stimulus, concentrations of Interferon-γ, tumor necrosis factor αand IL 2, 4, 6 and 10, using cytometric bead array, were assessed. Results Cell samples from eosinophilic nasal polyps from 13 patients were included in the study. Twenty-four hours after interferon-α stimulation, eosinophilic nasal polyp culture supernatants showed significantly decreased IL-4 concentrations and increase in interferon-γ, IL-10 and IL-6 concentrations compared to controls. There were no significant differences in tumor necrosis factor -α and IL-2 concentrations. Conclusion We demonstrated that interferon-α in vitro alters the pattern of cytokines in cell cultures of eosinophilic nasal polyps. Analysis of these alterations suggests that interferon-α promotes a rebalancing of inflammatory profiles in cell cultures, favoring the expression of Th1 and regulatory cytokines over Th2 cytokines.