cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.1254811
title: Respiration accumulates Calvin cycle intermediates for the rapid start of photosynthesis in <i>Synechocystis</i> sp. PCC 6803

description: We tested the hypothesis that inducing photosynthesis in cyanobacteria requires respiration. A mutant deficient in glycogen phosphorylase (∆GlgP) was prepared in <i>Synechocystis</i> sp. PCC 6803 to suppress respiration. The accumulated glycogen in ΔGlgP was 250–450% of that accumulated in wild type (WT). The rate of dark respiration in ΔGlgP was 25% of that in WT. In the dark, P700<sup>+</sup> reduction was suppressed in ΔGlgP, and the rate corresponded to that in (2,5-dibromo-3-methyl-6-isopropyl-<i>p</i>-benzoquinone)-treated WT, supporting a lower respiration rate in ∆GlgP. Photosynthetic O<sub>2</sub>-evolution rate reached a steady-state value much slower in ∆GlgP than in WT. This retardation was solved by addition of d-glucose. Furthermore, we found that the contents of Calvin cycle intermediates in ∆GlgP were lower than those in WT under dark conditions. These observations indicated that respiration provided the carbon source for regeneration of ribulose 1,5-bisphosphate in order to drive the rapid start of photosynthesis.
DOI: 10.6084/m9.figshare.1254811.v1
title: Respiration accumulates Calvin cycle intermediates for the rapid start of photosynthesis in <i>Synechocystis</i> sp. PCC 6803

description: We tested the hypothesis that inducing photosynthesis in cyanobacteria requires respiration. A mutant deficient in glycogen phosphorylase (∆GlgP) was prepared in <i>Synechocystis</i> sp. PCC 6803 to suppress respiration. The accumulated glycogen in ΔGlgP was 250–450% of that accumulated in wild type (WT). The rate of dark respiration in ΔGlgP was 25% of that in WT. In the dark, P700<sup>+</sup> reduction was suppressed in ΔGlgP, and the rate corresponded to that in (2,5-dibromo-3-methyl-6-isopropyl-<i>p</i>-benzoquinone)-treated WT, supporting a lower respiration rate in ∆GlgP. Photosynthetic O<sub>2</sub>-evolution rate reached a steady-state value much slower in ∆GlgP than in WT. This retardation was solved by addition of d-glucose. Furthermore, we found that the contents of Calvin cycle intermediates in ∆GlgP were lower than those in WT under dark conditions. These observations indicated that respiration provided the carbon source for regeneration of ribulose 1,5-bisphosphate in order to drive the rapid start of photosynthesis.
DOI: 10.6084/m9.figshare.1254779.v1
title: Gaussian Job Archive for C12H24I8N4

description: Archive of work produced using the resources of the Imperial College High Performance Computing Service.
DOI: 10.6084/m9.figshare.1254661
title: Incineration

description: Mass balance of Incineration
DOI: 10.6084/m9.figshare.1254645
title: CAJA OIT DE ALCOHOL INDUSTRIAL

description: ENTREGA DE TAREA ALCOHOL INDUSTRIAL IESS MANTA
DOI: 10.6084/m9.figshare.1254661.v1
title: Incineration

description: Mass balance of Incineration
DOI: 10.6084/m9.figshare.20016750.v1
title: FRAX Tool in Brazil: an integrative literature review following validation

description: Abstract The present article is an integrative review the objective of which was to assess research carried out with the FRAX tool in Brazil following its validation, and describe the conclusions drawn. Two databases were used to select the articles (the Capes Portal and the Virtual Health Library), and the sample of this review was the only four articles published in Brazil relating to the FRAX tool following its validation in May 2013. After analyzing the articles, the results demonstrated that despite some limitations the FRAX Tool can be used to reduce the prevalence of fractures due to its simplicity of use, with an emphasis on prediction and orientation, allowing early and safe therapeutic decision-making.
DOI: 10.6084/m9.figshare.20016750
title: FRAX Tool in Brazil: an integrative literature review following validation

description: Abstract The present article is an integrative review the objective of which was to assess research carried out with the FRAX tool in Brazil following its validation, and describe the conclusions drawn. Two databases were used to select the articles (the Capes Portal and the Virtual Health Library), and the sample of this review was the only four articles published in Brazil relating to the FRAX tool following its validation in May 2013. After analyzing the articles, the results demonstrated that despite some limitations the FRAX Tool can be used to reduce the prevalence of fractures due to its simplicity of use, with an emphasis on prediction and orientation, allowing early and safe therapeutic decision-making.
DOI: 10.6084/m9.figshare.6503912
title: Prevalence and factors associated with alcohol and tobacco use among non-institutionalized elderly persons

description: Abstract Objective: The present study aims to evaluate the prevalence of and factors associated with the use of tobacco and alcohol among elderly people living in the northern part of the city of Juiz de Fora, Minas Gerais, Brazil. Method: A cross-sectional study conducted through a home survey was performed with a sample of 423 elderly citizens. Interviews were conducted through a questionnaire including the Fagerström and Audit-C tests. The data were subjected to descriptive statistical analysis and multinomial regression. Results: The prevalence of elderly smokers was 9.0%, 32.0% were former smokers, 26.7% of the sample consumed alcoholic beverages and 3.2% used alcohol and smoked. In the multinomial logistic regression model, the factors that were significantly associated with smoking were the male gender, an age of 60 to 70 years old; the presence of self-reported health problems; while the consumption of alcohol was associated with the male gender and frailty. Conclusion: There was a low prevalence of elderly people living in the community who consumed alcoholic beverages and/or were smokers. Such individuals, however, almost exclusively suffered from impaired health and potentially a poor quality of life. Regarding the profile of such elderly persons, there were similarities between the socio-demographic and health variables, suggesting the possibility of a more targeted approach to these individuals.
DOI: 10.6084/m9.figshare.6503912.v1
title: Prevalence and factors associated with alcohol and tobacco use among non-institutionalized elderly persons

description: Abstract Objective: The present study aims to evaluate the prevalence of and factors associated with the use of tobacco and alcohol among elderly people living in the northern part of the city of Juiz de Fora, Minas Gerais, Brazil. Method: A cross-sectional study conducted through a home survey was performed with a sample of 423 elderly citizens. Interviews were conducted through a questionnaire including the Fagerström and Audit-C tests. The data were subjected to descriptive statistical analysis and multinomial regression. Results: The prevalence of elderly smokers was 9.0%, 32.0% were former smokers, 26.7% of the sample consumed alcoholic beverages and 3.2% used alcohol and smoked. In the multinomial logistic regression model, the factors that were significantly associated with smoking were the male gender, an age of 60 to 70 years old; the presence of self-reported health problems; while the consumption of alcohol was associated with the male gender and frailty. Conclusion: There was a low prevalence of elderly people living in the community who consumed alcoholic beverages and/or were smokers. Such individuals, however, almost exclusively suffered from impaired health and potentially a poor quality of life. Regarding the profile of such elderly persons, there were similarities between the socio-demographic and health variables, suggesting the possibility of a more targeted approach to these individuals.
DOI: 10.6084/m9.figshare.6503714
title: Impact of hospitalization on the functional capacity of the elderly: A cohort study

description: Abstract Objective: To verify the trajectory of the functional capacity of elderly persons hospitalized due to clinical conditions in a university hospital. Method: A descriptive, prospective cohort study was conducted between 2015 and 2016. Elderly patients admitted to the Hospital das Clínicas of Botucatu Medical School (Unesp), Brazil, were evaluated for the functional assessment of basic activities of daily living (BADL) using the Katz scale, nutritional status (body mass index (BMI)) and presence of the Frailty Syndrome (FS) (Fried criteria). A description of the trajectory of functional capacity was carried out at four times: 15 days before admission (T0), at admission (T1), at hospital discharge (T2) and 30 days after discharge (T3). Results: 99 elderly people with a mean age of 74 (+7.35) years, 59.6% of whom were male, were evaluated. Of these, 81.8% presented functional independence at T0, 45.5% at T1, 57.6% at T2 and 72.8% at T3. According to their functional trajectories, 28.2% of the elderly lost functional capacity between T0 and T3. There was an association between worsening of functional capacity between T0 and T3 and the FS (RR 4.56; 95% CI 1.70-12.26, p=0.003). Conclusion: Elderly patients have worse functional capacity at hospital discharge than before hospitalization. About 28.0% of the elderly had worse functional capacity 30 days after discharge than 15 days before admission. The elderly with Frailty Syndrome have a greater risk for worse functional capacity results 30 days after discharge.
DOI: 10.6084/m9.figshare.6503714.v1
title: Impact of hospitalization on the functional capacity of the elderly: A cohort study

description: Abstract Objective: To verify the trajectory of the functional capacity of elderly persons hospitalized due to clinical conditions in a university hospital. Method: A descriptive, prospective cohort study was conducted between 2015 and 2016. Elderly patients admitted to the Hospital das Clínicas of Botucatu Medical School (Unesp), Brazil, were evaluated for the functional assessment of basic activities of daily living (BADL) using the Katz scale, nutritional status (body mass index (BMI)) and presence of the Frailty Syndrome (FS) (Fried criteria). A description of the trajectory of functional capacity was carried out at four times: 15 days before admission (T0), at admission (T1), at hospital discharge (T2) and 30 days after discharge (T3). Results: 99 elderly people with a mean age of 74 (+7.35) years, 59.6% of whom were male, were evaluated. Of these, 81.8% presented functional independence at T0, 45.5% at T1, 57.6% at T2 and 72.8% at T3. According to their functional trajectories, 28.2% of the elderly lost functional capacity between T0 and T3. There was an association between worsening of functional capacity between T0 and T3 and the FS (RR 4.56; 95% CI 1.70-12.26, p=0.003). Conclusion: Elderly patients have worse functional capacity at hospital discharge than before hospitalization. About 28.0% of the elderly had worse functional capacity 30 days after discharge than 15 days before admission. The elderly with Frailty Syndrome have a greater risk for worse functional capacity results 30 days after discharge.
DOI: 10.6084/m9.figshare.6504497
title: Trends in overall mortality and from diseases of the circulatory system in elderly individuals in Rio Branco, Acre, 1980-2012

description: Abstract Objective: To analyze trends in general mortality and circulatory system disease mortality among elderly persons living in the city of Rio Branco, Acre, Brazil, from 1980 to 2012. Method: A study of the cause of death of elderly people was carried out from the data available in the Brazilian Mortality Information System. Crude and age-based overall and circulatory system mortality rates were calculated. The trend analyses of these rates were performed using the JoinPoint Regression program. Results: Despite the reductions in mortality rates, diseases of the circulatory system remained the main cause of death of the elderly in Rio Branco. The decrease in overall mortality rates was higher among elderly women and those aged 70 years or older. There was a tendency for death rates due to diseases of the circulatory system to decline among elderly men and grow among elderly women. Conclusion: The mortality rate among the elderly in Rio Branco revealed a declining trend. Deaths from diseases of the circulatory system were the leading cause of death, suggesting that research should be carried out to assess the need for investment to ensure that increased longevity is accompanied by good quality of life.
DOI: 10.6084/m9.figshare.6504497.v1
title: Trends in overall mortality and from diseases of the circulatory system in elderly individuals in Rio Branco, Acre, 1980-2012

description: Abstract Objective: To analyze trends in general mortality and circulatory system disease mortality among elderly persons living in the city of Rio Branco, Acre, Brazil, from 1980 to 2012. Method: A study of the cause of death of elderly people was carried out from the data available in the Brazilian Mortality Information System. Crude and age-based overall and circulatory system mortality rates were calculated. The trend analyses of these rates were performed using the JoinPoint Regression program. Results: Despite the reductions in mortality rates, diseases of the circulatory system remained the main cause of death of the elderly in Rio Branco. The decrease in overall mortality rates was higher among elderly women and those aged 70 years or older. There was a tendency for death rates due to diseases of the circulatory system to decline among elderly men and grow among elderly women. Conclusion: The mortality rate among the elderly in Rio Branco revealed a declining trend. Deaths from diseases of the circulatory system were the leading cause of death, suggesting that research should be carried out to assess the need for investment to ensure that increased longevity is accompanied by good quality of life.
DOI: 10.6084/m9.figshare.6504338
title: Profile of elderly persons with metabolic syndrome and factors associated with possible drug interactions

description: Abstract Objectives: To describe the sociodemographic, clinical and pharmacotherapy characteristics of elderly persons with metabolic syndrome and to identify factors associated with drug interactions among these individuals. Method: A quantitative, analytical and transversal study was carried out among 263 elderly people with metabolic syndrome in the urban area of Uberaba, Minas Gerais, Brazil. Possible drug interactions were identified and classified according to the Micromedex® DrugReax System. The chi-squared test and the multiple logistic regression model were used for analysis (p&lt;0.05). Results: The majority of the individuals were female (70.7%); aged 60 to 74 years (72.3%); lived with a spouse/partner (63.9%); had some schooling (74.1%); an individual monthly income of ≤ one minimum wage (77.1%); lived with others (88.2%); had five or more morbidities (89.7%) and exhibited polypharmacy (73.0%); used potentially inappropriate medications (54.4%) and had possible drug interactions (75.3%). Associated with the possible presence of drug interactions were: age range (p=0.005), polypharmacy (p&lt;0.001) and use of potentially inappropriate medications (p=0.006). Conclusion: Possible drug interactions were associated with increased age, polypharmacy and the use of potentially inappropriate medications. This study contributes to knowledge of these possible interactions among elderly people with metabolic syndrome, and as such can be considered an important tool for planning actions to ensure the safety of these individuals who, due to the complexity of their treatment, use multiple medications.
DOI: 10.6084/m9.figshare.6504338.v1
title: Profile of elderly persons with metabolic syndrome and factors associated with possible drug interactions

description: Abstract Objectives: To describe the sociodemographic, clinical and pharmacotherapy characteristics of elderly persons with metabolic syndrome and to identify factors associated with drug interactions among these individuals. Method: A quantitative, analytical and transversal study was carried out among 263 elderly people with metabolic syndrome in the urban area of Uberaba, Minas Gerais, Brazil. Possible drug interactions were identified and classified according to the Micromedex® DrugReax System. The chi-squared test and the multiple logistic regression model were used for analysis (p&lt;0.05). Results: The majority of the individuals were female (70.7%); aged 60 to 74 years (72.3%); lived with a spouse/partner (63.9%); had some schooling (74.1%); an individual monthly income of ≤ one minimum wage (77.1%); lived with others (88.2%); had five or more morbidities (89.7%) and exhibited polypharmacy (73.0%); used potentially inappropriate medications (54.4%) and had possible drug interactions (75.3%). Associated with the possible presence of drug interactions were: age range (p=0.005), polypharmacy (p&lt;0.001) and use of potentially inappropriate medications (p=0.006). Conclusion: Possible drug interactions were associated with increased age, polypharmacy and the use of potentially inappropriate medications. This study contributes to knowledge of these possible interactions among elderly people with metabolic syndrome, and as such can be considered an important tool for planning actions to ensure the safety of these individuals who, due to the complexity of their treatment, use multiple medications.
DOI: 10.6084/m9.figshare.6504188
title: Burden, profile and care: caregivers of socially vulnerable elderly persons

description: Abstract Objectives: To compare burden and sociodemographic profile and to analyze the care needs of caregivers of elderly persons enrolled in Social Care Referral Centers in a municipal region in the interior of the state of São Paulo, Brazil. Method: A cross-sectional, quantitative-qualitative study was carried out. A sociodemographic questionnaire, the Zarit Burden Scale and three open questions regarding care needs were applied. The quantitative data were analyzed by descriptive statistics and the correlation test. The hermeneutic-dialectic referential was applied and the qualitative data were analyzed by the content analysis technique. Results: A total of 86 caregivers participated in the study. The majority were female (71.7%), had a mean age of 56.5 (sd=14.9) years, suffered burden and lived in vulnerable neighborhoods. With regard to care, the provision of support for activities of daily living, difficulties in caring and the help of other relatives were identified. Burden negatively correlated with age range and schooling (r=-0.11; r=-0.87). Conclusion: Guidance and the acquisition of caring skills remain unprovided by the resources and services that exist in vulnerable contexts, and resolutive support strategies are lacking in public facilities.
DOI: 10.6084/m9.figshare.6504188.v1
title: Burden, profile and care: caregivers of socially vulnerable elderly persons

description: Abstract Objectives: To compare burden and sociodemographic profile and to analyze the care needs of caregivers of elderly persons enrolled in Social Care Referral Centers in a municipal region in the interior of the state of São Paulo, Brazil. Method: A cross-sectional, quantitative-qualitative study was carried out. A sociodemographic questionnaire, the Zarit Burden Scale and three open questions regarding care needs were applied. The quantitative data were analyzed by descriptive statistics and the correlation test. The hermeneutic-dialectic referential was applied and the qualitative data were analyzed by the content analysis technique. Results: A total of 86 caregivers participated in the study. The majority were female (71.7%), had a mean age of 56.5 (sd=14.9) years, suffered burden and lived in vulnerable neighborhoods. With regard to care, the provision of support for activities of daily living, difficulties in caring and the help of other relatives were identified. Burden negatively correlated with age range and schooling (r=-0.11; r=-0.87). Conclusion: Guidance and the acquisition of caring skills remain unprovided by the resources and services that exist in vulnerable contexts, and resolutive support strategies are lacking in public facilities.
DOI: 10.6084/m9.figshare.6503213
title: Quality of life and time since diagnosis of Diabetes Mellitus among the elderly

description: Abstract Objectives: To evaluate the quality of life of the elderly with Diabetes Mellitus and to relate the time since diagnosis of diabetes with the quality of life of elderly persons receiving care at a basic health unit. Method: A cross-sectional quantitative study carried out in a Basic Health Unit with 196 elderly persons. For data collection, three instruments were used: one structured (sociodemographic and clinical variables) and the Whoqol-bref and Whoqol-old, with scores ranging from 0 to 100. Descriptive statistical analysis, Student’s T-test and Pearson’s correlation were performed. Results: Of the 196 diabetic patients, the majority were male (54.6%) with a mean age of 67.5 (±6.5) years. The mean time since diagnosis of Diabetes Mellitus was 9.1 years. The domains of the Whoqol-bref with the highest scores, indicating better quality of life, were Social Relations and Psychological, while a worse quality of life was observed in Environment. The facets of the Whoqol-old with the best scores were: Intimacy and Past, Present and Future Activities, and the worst was Death and Dying. The domains associated with one another were Physical and Psychological, Physical and Social Relations, and Psychological and Environmental. The associated aspects were Past, Present and Future Activities and Social Participation. Elderly persons with more than ten years of Diabetes Mellitus had worse quality of life scores in Physical (p=0.001), Social relations (p=0.002), and in the Autonomy (p=0.0012), Social Participation (p=0.041) and Death and Dying (p=0.001) facets. Conclusion: The time of diagnosis of Diabetes Mellitus was negatively associated with the quality of life of the elderly, with worse scores in most domains and facets of the Whoqol.
DOI: 10.6084/m9.figshare.6503213.v1
title: Quality of life and time since diagnosis of Diabetes Mellitus among the elderly

description: Abstract Objectives: To evaluate the quality of life of the elderly with Diabetes Mellitus and to relate the time since diagnosis of diabetes with the quality of life of elderly persons receiving care at a basic health unit. Method: A cross-sectional quantitative study carried out in a Basic Health Unit with 196 elderly persons. For data collection, three instruments were used: one structured (sociodemographic and clinical variables) and the Whoqol-bref and Whoqol-old, with scores ranging from 0 to 100. Descriptive statistical analysis, Student’s T-test and Pearson’s correlation were performed. Results: Of the 196 diabetic patients, the majority were male (54.6%) with a mean age of 67.5 (±6.5) years. The mean time since diagnosis of Diabetes Mellitus was 9.1 years. The domains of the Whoqol-bref with the highest scores, indicating better quality of life, were Social Relations and Psychological, while a worse quality of life was observed in Environment. The facets of the Whoqol-old with the best scores were: Intimacy and Past, Present and Future Activities, and the worst was Death and Dying. The domains associated with one another were Physical and Psychological, Physical and Social Relations, and Psychological and Environmental. The associated aspects were Past, Present and Future Activities and Social Participation. Elderly persons with more than ten years of Diabetes Mellitus had worse quality of life scores in Physical (p=0.001), Social relations (p=0.002), and in the Autonomy (p=0.0012), Social Participation (p=0.041) and Death and Dying (p=0.001) facets. Conclusion: The time of diagnosis of Diabetes Mellitus was negatively associated with the quality of life of the elderly, with worse scores in most domains and facets of the Whoqol.