cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.28099003
title: Additional file 10 of SPP1+ macrophages promote head and neck squamous cell carcinoma progression by secreting TNF-α and IL-1β

description: Supplementary Material 10.
DOI: 10.6084/m9.figshare.28099014
title: Additional file 2 of Comparative genomics of Fervidobacterium: a new phylogenomic landscape of these wide-spread thermophilic anaerobes

description: Supplementary Material 2.
DOI: 10.6084/m9.figshare.28099006
title: Additional file 11 of SPP1+ macrophages promote head and neck squamous cell carcinoma progression by secreting TNF-α and IL-1β

description: Supplementary Material 11.
DOI: 10.34740/kaggle/dsv/10308524
title: Egypt Gold Prices | Daily Updated
DOI: 10.6084/m9.figshare.22593426
title: Iodine doping of CsPbBr<sub>3</sub>: toward highly stable and clean perovskite single crystals for optoelectronic applications

description: Caesium-based mixed halide perovskite single crystals, CsPbBr<sub>3-x</sub>I<sub>x</sub>, are shown to be good candidates for many optoelectronic applications under ambient conditions. The partial substitution of iodine into the bromine sites of CsPbBr<sub>3</sub> single crystal makes attractive effects in optical and structural properties as well as their thermal and phase stability. Herein, the Inverse Temperature Crystallization (ITC) method has been utilised to grow high-quality, large, and single-phase single crystals of CsPbBr<sub>2.4</sub>I<sub>0.6</sub> perovskites. The iodine doping is found to result in improved purity, thermal, phase, and atmospheric stability of the single crystal and helped to tune the band gap. Further, there is a conspicuous decrease in the defect density with iodine doping. Thus the present study establishes iodine doping as a facile route to grow CsPbBr<sub>3</sub> single crystals with overall stability and improved defect density with a broad absorption spectrum, that point toward extended optoelectronic and photovoltaic applications.
DOI: 10.6084/m9.figshare.22593426.v1
title: Iodine doping of CsPbBr<sub>3</sub>: toward highly stable and clean perovskite single crystals for optoelectronic applications

description: Caesium-based mixed halide perovskite single crystals, CsPbBr<sub>3-x</sub>I<sub>x</sub>, are shown to be good candidates for many optoelectronic applications under ambient conditions. The partial substitution of iodine into the bromine sites of CsPbBr<sub>3</sub> single crystal makes attractive effects in optical and structural properties as well as their thermal and phase stability. Herein, the Inverse Temperature Crystallization (ITC) method has been utilised to grow high-quality, large, and single-phase single crystals of CsPbBr<sub>2.4</sub>I<sub>0.6</sub> perovskites. The iodine doping is found to result in improved purity, thermal, phase, and atmospheric stability of the single crystal and helped to tune the band gap. Further, there is a conspicuous decrease in the defect density with iodine doping. Thus the present study establishes iodine doping as a facile route to grow CsPbBr<sub>3</sub> single crystals with overall stability and improved defect density with a broad absorption spectrum, that point toward extended optoelectronic and photovoltaic applications.
DOI: 10.6084/m9.figshare.25734077.v1
title: Copy number variant risk loci for schizophrenia converge on the BDNF pathway

description: Schizophrenia genetics is intricate, with common and rare variants’ contributions not fully understood. Certain copy number variations (CNVs) elevate risk, pivotal for understanding mental disorder models. Despite CNVs’ genome-wide distribution and variable gene and protein effects, we must explore beyond affected genes to interaction partners and molecular pathways. In this study, we developed machine-readable interactive pathways to enable analysis of functional effects of genes within CNV loci and identify ten common pathways across CNVs with high schizophrenia risk using the WikiPathways database, schizophrenia risk gene collections from GWAS studies, and a gene-disease association database. For CNVs that are pathogenic for schizophrenia, we found overlapping pathways, including BDNF signalling, cytoskeleton, and inflammation. Common schizophrenia risk genes identified by different studies are found in all CNV pathways, but not enriched. Our findings suggest that specific pathways - BDNF signalling - are critical contributors to schizophrenia risk conferred by rare CNVs. Our approach highlights the importance of not only investigating deleted or duplicated genes within pathogenic CNV loci, but also study their direct interaction partners, which may explain pleiotropic effects of CNVs on schizophrenia risk and offer a broader field for interventions.
DOI: 10.6084/m9.figshare.25425288.v1
title: Lymphoblast transcriptome analysis in 22q11.2 deletion syndrome individuals with schizophrenia-spectrum disorder

description: 22q11.2 deletion is the most prominent risk factor for schizophrenia (SZ). The aim of the present study was to identify unique transcriptome profile for 22q11.2 deletion syndrome (DS)-related SZ-spectrum disorder (SZ-SD). We performed RNA-Seq screening in lymphoblasts collected from 20 individuals with 22q11.2DS (10 men and 10 women, four of each sex with SZ-SD and six with no psychotic disorders (Np)). Sex effect in RNA-Seq descriptive analysis led to separating the analyses between men and women. In women, only one differentially expressed gene (DEG), <i>HLA-DQA2</i>, was associated with SZ-SD. In men, 48 DEGs (adjp &lt; 0.05) were found to be associated with SZ-SD. Ingenuity pathway analysis of top 85 DEGs (<i>p</i> &lt; 4.66E − 04) indicated significant enrichment for immune-inflammatory response (IIR) and neuro-inflammatory signalling pathways. Additionally, NFATC2, IFNG, IFN-alpha, STAT1 and IL-4 were identified as upstream regulators. Co-expression network analysis revealed the contribution of endoplasmic reticulum protein processing and N-Glycan biosynthesis. These findings indicate dysregulation of IIR and post-translational protein modification processes in individuals with 22q11.2DS-related SZ-SD. Candidate pathways and upstream regulators may serve as novel biomarkers and treatment targets for SZ. Future transcriptome studies, including larger samples and proteomic analysis, are needed to substantiate our findings.
DOI: 10.6084/m9.figshare.25734077
title: Copy number variant risk loci for schizophrenia converge on the BDNF pathway

description: Schizophrenia genetics is intricate, with common and rare variants’ contributions not fully understood. Certain copy number variations (CNVs) elevate risk, pivotal for understanding mental disorder models. Despite CNVs’ genome-wide distribution and variable gene and protein effects, we must explore beyond affected genes to interaction partners and molecular pathways. In this study, we developed machine-readable interactive pathways to enable analysis of functional effects of genes within CNV loci and identify ten common pathways across CNVs with high schizophrenia risk using the WikiPathways database, schizophrenia risk gene collections from GWAS studies, and a gene-disease association database. For CNVs that are pathogenic for schizophrenia, we found overlapping pathways, including BDNF signalling, cytoskeleton, and inflammation. Common schizophrenia risk genes identified by different studies are found in all CNV pathways, but not enriched. Our findings suggest that specific pathways - BDNF signalling - are critical contributors to schizophrenia risk conferred by rare CNVs. Our approach highlights the importance of not only investigating deleted or duplicated genes within pathogenic CNV loci, but also study their direct interaction partners, which may explain pleiotropic effects of CNVs on schizophrenia risk and offer a broader field for interventions.
DOI: 10.6084/m9.figshare.25734078.v2
title: Frequencies of <i>CYP2C19</i> and <i>CYP2D6</i> gene variants in a German inpatient sample with mood and anxiety disorders

description: Previous results demonstrated that <i>CYP2D6</i> and <i>CYP2C19</i> gene variants affect serum concentrations of antidepressants. We implemented a PGx service determining gene variants in <i>CYP2D6</i> and <i>CYP2C19</i> in our clinical routine care and report on our first patient cohort. We analysed <i>CYP2D6</i> and <i>CYP2C19</i> allele, genotype, and phenotype frequencies, and actionable pharmacogenetic variants in this German psychiatric inpatient cohort. Two-tailed <i>z</i>-test was used to investigate for differences in <i>CYP2D6</i> and <i>CYP2C19</i> phenotypes and actionable/non-actionable genetic variant frequencies between our cohort and reference cohorts. Out of the 154 patients included, 44.8% of patients were classified as CYP2D6 normal metabolizer, 38.3% as intermediate metabolizers, 8.4% as poor metabolizers, and 2.6% as ultrarapid metabolizers. As for CYP2C19, 40.9% of patients were classified as normal metabolizers, 19.5% as intermediate metabolizers, 2.6% as poor metabolizers, 31.2% as rapid metabolizers, and 5.8% as ultrarapid metabolizers. Approximately, 80% of patients had at least one actionable PGx variant. There is a high prevalence of actionable PGx variants in psychiatric inpatients which may affect treatment response. Physicians should refer to PGx-informed dosing guidelines in carriers of these variants. Pre-emptive PGx testing in general may facilitate <i>precision medicine</i> also for other drugs metabolised by CYP2D6 and/or CYP2C19.
DOI: 10.6084/m9.figshare.25425288
title: Lymphoblast transcriptome analysis in 22q11.2 deletion syndrome individuals with schizophrenia-spectrum disorder

description: 22q11.2 deletion is the most prominent risk factor for schizophrenia (SZ). The aim of the present study was to identify unique transcriptome profile for 22q11.2 deletion syndrome (DS)-related SZ-spectrum disorder (SZ-SD). We performed RNA-Seq screening in lymphoblasts collected from 20 individuals with 22q11.2DS (10 men and 10 women, four of each sex with SZ-SD and six with no psychotic disorders (Np)). Sex effect in RNA-Seq descriptive analysis led to separating the analyses between men and women. In women, only one differentially expressed gene (DEG), <i>HLA-DQA2</i>, was associated with SZ-SD. In men, 48 DEGs (adjp &lt; 0.05) were found to be associated with SZ-SD. Ingenuity pathway analysis of top 85 DEGs (<i>p</i> &lt; 4.66E − 04) indicated significant enrichment for immune-inflammatory response (IIR) and neuro-inflammatory signalling pathways. Additionally, NFATC2, IFNG, IFN-alpha, STAT1 and IL-4 were identified as upstream regulators. Co-expression network analysis revealed the contribution of endoplasmic reticulum protein processing and N-Glycan biosynthesis. These findings indicate dysregulation of IIR and post-translational protein modification processes in individuals with 22q11.2DS-related SZ-SD. Candidate pathways and upstream regulators may serve as novel biomarkers and treatment targets for SZ. Future transcriptome studies, including larger samples and proteomic analysis, are needed to substantiate our findings.
DOI: 10.6084/m9.figshare.25734078
title: Frequencies of <i>CYP2C19</i> and <i>CYP2D6</i> gene variants in a German inpatient sample with mood and anxiety disorders

description: Previous results demonstrated that <i>CYP2D6</i> and <i>CYP2C19</i> gene variants affect serum concentrations of antidepressants. We implemented a PGx service determining gene variants in <i>CYP2D6</i> and <i>CYP2C19</i> in our clinical routine care and report on our first patient cohort. We analysed <i>CYP2D6</i> and <i>CYP2C19</i> allele, genotype, and phenotype frequencies, and actionable pharmacogenetic variants in this German psychiatric inpatient cohort. Two-tailed <i>z</i>-test was used to investigate for differences in <i>CYP2D6</i> and <i>CYP2C19</i> phenotypes and actionable/non-actionable genetic variant frequencies between our cohort and reference cohorts. Out of the 154 patients included, 44.8% of patients were classified as CYP2D6 normal metabolizer, 38.3% as intermediate metabolizers, 8.4% as poor metabolizers, and 2.6% as ultrarapid metabolizers. As for CYP2C19, 40.9% of patients were classified as normal metabolizers, 19.5% as intermediate metabolizers, 2.6% as poor metabolizers, 31.2% as rapid metabolizers, and 5.8% as ultrarapid metabolizers. Approximately, 80% of patients had at least one actionable PGx variant. There is a high prevalence of actionable PGx variants in psychiatric inpatients which may affect treatment response. Physicians should refer to PGx-informed dosing guidelines in carriers of these variants. Pre-emptive PGx testing in general may facilitate <i>precision medicine</i> also for other drugs metabolised by CYP2D6 and/or CYP2C19.
DOI: 10.5281/zenodo.14560522
title: Global White Inorganic Pigments Market 2024 To 2033

description: White Inorganic Pigments Market Size, Trends and Insights By Type (Titanium Dioxide, Zinc Oxide, Aluminium Silicate, Calcium Carbonate, Calcium Silicate, Silica, Others), By Application (Paints and Coatings, Plastics, Printing Inks, Cosmetics, Others), and By Region - Global Industry Overview, Statistical Data, Competitive Analysis, Share, Outlook, and Forecast 2024–2033.

Reports Description

Global White Inorganic Pigments Market was valued at USD 30.3 Million in 2024 and is expected to reach USD 54.6 Million by 2033, at a CAGR of 6.7% during the forecast period 2024 – 2033.

White inorganic pigments are substances used to impart whiteness, opacity, and brightness to various materials such as paints, coatings, plastics, ceramics, and paper. These pigments are valued for their high refractive index, which allows them to scatter and reflect light effectively, resulting in a bright white appearance.

For more information, DOWNLOAD FREE SAMPLE Now at https://www.custommarketinsights.com/request-for-free-sample/?reportid=52462
DOI: 10.5281/zenodo.14560510
title: Global Trimethylhydroquinone Market 2024 To 2033

description: Trimethylhydroquinone Market Size, Trends and Insights By Type (Pharmaceutical Grade, Industrial Grade, Bio-Based), By Application (Synthesis of Vitamin E, Pharmaceuticals, Dyes & Pigments, Food & Cosmetics, Others), and By Region - Global Industry Overview, Statistical Data, Competitive Analysis, Share, Outlook, and Forecast 2024–2033.

Reports Description

Global Trimethylhydroquinone Market was valued at USD 728.3 Million in 2024 and is expected to reach USD 998.6 Million by 2033, at a CAGR of 4.7% during the forecast period 2024 – 2033.

Trimethylhydroquinone is an organic compound with the molecular formula C9H12O2. It is a derivative of hydroquinone where three methyl groups are added to the benzene ring. This compound is notable for its use in the synthesis of various antioxidants, particularly those used in the food and cosmetic industries.

For more information, DOWNLOAD FREE SAMPLE Now at https://www.custommarketinsights.com/request-for-free-sample/?reportid=52448
DOI: 10.5281/zenodo.14560521
title: Global White Inorganic Pigments Market 2024 To 2033

description: White Inorganic Pigments Market Size, Trends and Insights By Type (Titanium Dioxide, Zinc Oxide, Aluminium Silicate, Calcium Carbonate, Calcium Silicate, Silica, Others), By Application (Paints and Coatings, Plastics, Printing Inks, Cosmetics, Others), and By Region - Global Industry Overview, Statistical Data, Competitive Analysis, Share, Outlook, and Forecast 2024–2033.

Reports Description

Global White Inorganic Pigments Market was valued at USD 30.3 Million in 2024 and is expected to reach USD 54.6 Million by 2033, at a CAGR of 6.7% during the forecast period 2024 – 2033.

White inorganic pigments are substances used to impart whiteness, opacity, and brightness to various materials such as paints, coatings, plastics, ceramics, and paper. These pigments are valued for their high refractive index, which allows them to scatter and reflect light effectively, resulting in a bright white appearance.

For more information, DOWNLOAD FREE SAMPLE Now at https://www.custommarketinsights.com/request-for-free-sample/?reportid=52462
DOI: 10.5281/zenodo.14560527
title: Global Reactive Hot Melt Adhesive Market 2024 To 2033

description: Reactive Hot Melt Adhesive Market Size, Trends and Insights By Resin Type (Polyurethane, Polyolefin, Others), By Substrate (Plastic, Wood, Others), By Application (Automotive & Transportation, Doors & Windows, Lamination, Textile, Assembly, Others), and By Region - Global Industry Overview, Statistical Data, Competitive Analysis, Share, Outlook, and Forecast 2024–2033.

Reports Description

Global Reactive Hot Melt Adhesive Market was valued at USD 1.5 Billion in 2024 and is expected to reach USD 4.3 Billion by 2033, at a CAGR of 7.2% during the forecast period 2024 – 2033.

Reactive hot melt adhesive (RHMA) is a type of adhesive that combines the advantages of hot melt adhesives with the strength and durability of reactive chemistries.

For more information, DOWNLOAD FREE SAMPLE Now at https://www.custommarketinsights.com/request-for-free-sample/?reportid=52427
DOI: 10.5281/zenodo.14560528
title: Global Reactive Hot Melt Adhesive Market 2024 To 2033

description: Reactive Hot Melt Adhesive Market Size, Trends and Insights By Resin Type (Polyurethane, Polyolefin, Others), By Substrate (Plastic, Wood, Others), By Application (Automotive & Transportation, Doors & Windows, Lamination, Textile, Assembly, Others), and By Region - Global Industry Overview, Statistical Data, Competitive Analysis, Share, Outlook, and Forecast 2024–2033.

Reports Description

Global Reactive Hot Melt Adhesive Market was valued at USD 1.5 Billion in 2024 and is expected to reach USD 4.3 Billion by 2033, at a CAGR of 7.2% during the forecast period 2024 – 2033.

Reactive hot melt adhesive (RHMA) is a type of adhesive that combines the advantages of hot melt adhesives with the strength and durability of reactive chemistries.

For more information, DOWNLOAD FREE SAMPLE Now at https://www.custommarketinsights.com/request-for-free-sample/?reportid=52427
DOI: 10.5281/zenodo.14560503
title: Global Solvent Recovery and Recycling Market 2024 To 2033

description: Solvent Recovery and Recycling Market Size, Trends and Insights By Product Type (On-Site, Off-Site), By Process Technology (Adsorption, Distillation, Liquid-Liquid Extraction, Membrane Separation), By Application (Paints & Coatings, Printing, Chemicals, Electronics, Pharmaceuticals), and By Region - Global Industry Overview, Statistical Data, Competitive Analysis, Share, Outlook, and Forecast 2024–2033.

Reports Description

Global Solvent Recovery and Recycling Market was valued at USD 1.2 Billion in 2024 and is expected to reach USD 2.3 Billion by 2033, at a CAGR of 6.7% during the forecast period 2024 – 2033.

Solvent recovery and recycling refer to the processes of recovering, purifying, and reusing solvents that have been used in industrial processes. Solvents are chemicals used to dissolve, dilute, or suspend other substances, commonly employed in industries such as pharmaceuticals, chemicals, paints, coatings, and electronics manufacturing.

For more information, DOWNLOAD FREE SAMPLE Now at https://www.custommarketinsights.com/request-for-free-sample/?reportid=52439
DOI: 10.5281/zenodo.14560509
title: Global Trimethylhydroquinone Market 2024 To 2033

description: Trimethylhydroquinone Market Size, Trends and Insights By Type (Pharmaceutical Grade, Industrial Grade, Bio-Based), By Application (Synthesis of Vitamin E, Pharmaceuticals, Dyes & Pigments, Food & Cosmetics, Others), and By Region - Global Industry Overview, Statistical Data, Competitive Analysis, Share, Outlook, and Forecast 2024–2033.

Reports Description

Global Trimethylhydroquinone Market was valued at USD 728.3 Million in 2024 and is expected to reach USD 998.6 Million by 2033, at a CAGR of 4.7% during the forecast period 2024 – 2033.

Trimethylhydroquinone is an organic compound with the molecular formula C9H12O2. It is a derivative of hydroquinone where three methyl groups are added to the benzene ring. This compound is notable for its use in the synthesis of various antioxidants, particularly those used in the food and cosmetic industries.

For more information, DOWNLOAD FREE SAMPLE Now at https://www.custommarketinsights.com/request-for-free-sample/?reportid=52448
DOI: 10.5281/zenodo.14560532
title: Global Polylysine Market 2024 To 2033

description: Polylysine Market Size, Trends and Insights By Form (Powder, Liquid), By Application (Food and Beverage, Pharmaceuticals, Nutraceuticals, Cosmetics and Personal Care, Pet Food, Animal Feed), By Source (Natural, Synthetic), By Function (Antimicrobial Agent, Preservative, Drug Delivery Agent, Antioxidant) and By Region - Global Industry Overview, Statistical Data, Competitive Analysis, Share, Outlook, and Forecast 2024–2033.

Reports Description

Global Polylysine Market was valued at USD 728.3 Million in 2024 and is expected to reach USD 942.6 Million by 2033, at a CAGR of 5.7% during the forecast period 2024 – 2033.

Polylysine refers to a polymer composed of multiple lysine amino acids linked together. Lysine is a naturally occurring amino acid, which is one of the building blocks of proteins. When lysine residues are linked together in a chain, the resulting molecule is called polylysine.

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DOI: 10.5281/zenodo.14560533
title: Global Polylysine Market 2024 To 2033

description: Polylysine Market Size, Trends and Insights By Form (Powder, Liquid), By Application (Food and Beverage, Pharmaceuticals, Nutraceuticals, Cosmetics and Personal Care, Pet Food, Animal Feed), By Source (Natural, Synthetic), By Function (Antimicrobial Agent, Preservative, Drug Delivery Agent, Antioxidant) and By Region - Global Industry Overview, Statistical Data, Competitive Analysis, Share, Outlook, and Forecast 2024–2033.

Reports Description

Global Polylysine Market was valued at USD 728.3 Million in 2024 and is expected to reach USD 942.6 Million by 2033, at a CAGR of 5.7% during the forecast period 2024 – 2033.

Polylysine refers to a polymer composed of multiple lysine amino acids linked together. Lysine is a naturally occurring amino acid, which is one of the building blocks of proteins. When lysine residues are linked together in a chain, the resulting molecule is called polylysine.

For more information, DOWNLOAD FREE SAMPLE Now at https://www.custommarketinsights.com/request-for-free-sample/?reportid=52409
DOI: 10.5281/zenodo.14560534
title: Natural history specimens collected and/or identified and deposited.

description: Natural history specimen data collected and/or identified by William Larrey McCart, http://www.wikidata.org/entity/Q131557220. Claims or attributions were made on Bionomia, https://bionomia.net using specimen data from the Global Biodiversity Information Facility, https://gbif.org.
description: http://www.wikidata.org/entity/Q131557220
DOI: 10.5281/zenodo.14560535
title: Natural history specimens collected and/or identified and deposited.

description: Natural history specimen data collected and/or identified by William Larrey McCart, http://www.wikidata.org/entity/Q131557220. Claims or attributions were made on Bionomia, https://bionomia.net using specimen data from the Global Biodiversity Information Facility, https://gbif.org.
description: http://www.wikidata.org/entity/Q131557220