cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.12366329
title: In-silico strategies for probing chloroquine based inhibitors against SARS-CoV-2

description: The global health emergency of novel COVID-19 is due to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Currently there are no approved drugs for the treatment of coronaviral disease (COVID-19), although some of the drugs have been tried. Chloroquine is being widely used in treatment of SARS-CoV-2 infection. Hydroxychloroquine, the derivative of Chloroquine shows better inhibition than Chloroquine and has in vitro activity against SARS-CoV-2 also used to treat COVID-19. To study the interactions of Chloroquine and derivatives of Chloroquine with SARS-CoV-2, series of computational approaches like pharmacophore model, molecular docking, MM_GBSA study and ADME property analysis are explored. The pharmacophore model and molecular docking study are used to explore the structural properties of the compounds and the ligand-receptor (<b>PDB_ID: 6LU7</b>) interactions respectively. MM_GBSA study gives the binding free energy of the protein-ligand complex and ADME property analysis explains the pharmacological property of the compounds. The resultant best molecule (<b>CQD15)</b> further subjected to molecular dynamics (MD) simulation study which explains the protein stability (RMSD), ligand properties as well as protein-ligand contacts. Outcomes of the present study conclude with the molecule <b>CQD15</b> which shows better interactions for the inhibition of SARS-CoV-2 in comparison to Chloroquine and Hydroxychloroquine. Communicated by Ramaswamy H. Sarma
DOI: 10.6084/m9.figshare.12366335
title: Delayed emergence after mitigation, MAGICC6 scenarios and output

description: Scenario files and results used in the paper<br> Delayed emergence of a global temperature response after emission mitigation<br>by<br> Samset, B.H., Fuglestvedt, J. S., Lund, M. T.<br>published in<br> Nature Communications, 2020<br><br>Contents:<br>SCEN: The scenario emission files used as input to MAGICC6OUTPUT: All MAGICC6 output files from each simulation<br>Naming (see the paper for details):<br>ZERO: Anthropogenic emissions of one component set to zero from 2020 and onFIVE: Anthropogenic emissions of one component reduced by 5% per year from 2020RCP26: Anthropogenic emissions of one component swithed from RCP4.5 to RCP2.6 from 2020<br>For questions, please contact<br> Bjørn H. Samset, b.h.samset@cicero.oslo.no<br>
DOI: 10.6084/m9.figshare.12366335.v1
title: Delayed emergence after mitigation, MAGICC6 scenarios and output

description: Scenario files and results used in the paper<br> Delayed emergence of a global temperature response after emission mitigation<br>by<br> Samset, B.H., Fuglestvedt, J. S., Lund, M. T.<br>published in<br> Nature Communications, 2020<br><br>Contents:<br>SCEN: The scenario emission files used as input to MAGICC6OUTPUT: All MAGICC6 output files from each simulation<br>Naming (see the paper for details):<br>ZERO: Anthropogenic emissions of one component set to zero from 2020 and onFIVE: Anthropogenic emissions of one component reduced by 5% per year from 2020RCP26: Anthropogenic emissions of one component swithed from RCP4.5 to RCP2.6 from 2020<br>For questions, please contact<br> Bjørn H. Samset, b.h.samset@cicero.oslo.no<br>
DOI: 10.6084/m9.figshare.12366329.v2
title: In-silico strategies for probing chloroquine based inhibitors against SARS-CoV-2

description: The global health emergency of novel COVID-19 is due to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Currently there are no approved drugs for the treatment of coronaviral disease (COVID-19), although some of the drugs have been tried. Chloroquine is being widely used in treatment of SARS-CoV-2 infection. Hydroxychloroquine, the derivative of Chloroquine shows better inhibition than Chloroquine and has in vitro activity against SARS-CoV-2 also used to treat COVID-19. To study the interactions of Chloroquine and derivatives of Chloroquine with SARS-CoV-2, series of computational approaches like pharmacophore model, molecular docking, MM_GBSA study and ADME property analysis are explored. The pharmacophore model and molecular docking study are used to explore the structural properties of the compounds and the ligand-receptor (<b>PDB_ID: 6LU7</b>) interactions respectively. MM_GBSA study gives the binding free energy of the protein-ligand complex and ADME property analysis explains the pharmacological property of the compounds. The resultant best molecule (<b>CQD15)</b> further subjected to molecular dynamics (MD) simulation study which explains the protein stability (RMSD), ligand properties as well as protein-ligand contacts. Outcomes of the present study conclude with the molecule <b>CQD15</b> which shows better interactions for the inhibition of SARS-CoV-2 in comparison to Chloroquine and Hydroxychloroquine. Communicated by Ramaswamy H. Sarma
DOI: 10.6084/m9.figshare.12366272
title: Table S5

description: Table S5 All haplotypes of the 9 specific sites and numbers of them for 3624 and 16373 genomes respectively<br> <br>
DOI: 10.6084/m9.figshare.12366275
title: Table S6

description: Table S6 Whole genome mutations and frequencies in each major haplotype subgroup of 3624 and 16373 genomes respectively<br>
DOI: 10.6084/m9.figshare.12366278
title: Impact on rats from acute intratracheal inhalation exposures to WTC dusts

description: <b>Background:</b> Studies have revealed the increased incidence of health disorders in First Responders (FR) who were at Ground Zero over the initial 72 hr after the World Trade Center (WTC) collapses. Previous studies in rats exposed to WTC dusts using exposure scenarios that mimicked FR mouthbreathing showed exposure led to altered expression of genes whose products could be involved in lung ailments. Nevertheless, it was uncertain if repeated exposures (as occurred in earliest days post-disaster) might have given rise to long-term changes in the lungs/other organs, in white blood cell (WBC) profiles, and/or systemic expression of select (mostly immune-related) proteins. <b>Methods:</b> To examine this, rats were exposed on 2 consecutive days (2 hr/d, intratracheal inhalation) to WTC dusts and then examined over a 1-yr period thereafter. At select times post-exposure, organ (lung, heart, liver, kidney, spleen) weights, WBC profiles, and blood levels of a variety of proteins were evaluated. <b>Results:</b> The study showed that over the 1-yr period, there were nominal effects on organ weights (absolute, index) as a result of the dust exposures. There were significant changes (relative to in naïve rats) in WBC profiles, with exposed rats having increased monocyte-macrophage and decreased lymphocyte percentages. The study also found that dust exposure led to significant systemic increases in many proteins, including MCP-1, RANTES, MMP-9, RAGE, and Galectin-3. <b>Conclusions:</b> These results provide further support for our longstanding hypothesis that the WTC dusts could potentially have acted as direct inducers of many of the health effects that have been seen in the exposed FR.
DOI: 10.6084/m9.figshare.12366269
title: Table S4

description: Table S4 The information of death rate, frequencies of the 9 specific sites and major haplotypes in each country for 3624 and 16373 genomes respectively<br> <br>
DOI: 10.6084/m9.figshare.12366266
title: Table S3

description: Table S3 The details information of the SNVs in all Clusters
DOI: 10.6084/m9.figshare.12366269.v1
title: Table S4

description: Table S4 The information of death rate, frequencies of the 9 specific sites and major haplotypes in each country for 3624 and 16373 genomes respectively<br> <br>
DOI: 10.6084/m9.figshare.12366272.v1
title: Table S5

description: Table S5 All haplotypes of the 9 specific sites and numbers of them for 3624 and 16373 genomes respectively<br> <br>
DOI: 10.6084/m9.figshare.12366275.v1
title: Table S6

description: Table S6 Whole genome mutations and frequencies in each major haplotype subgroup of 3624 and 16373 genomes respectively<br>
DOI: 10.6084/m9.figshare.12366278.v1
title: Impact on rats from acute intratracheal inhalation exposures to WTC dusts

description: <b>Background:</b> Studies have revealed the increased incidence of health disorders in First Responders (FR) who were at Ground Zero over the initial 72 hr after the World Trade Center (WTC) collapses. Previous studies in rats exposed to WTC dusts using exposure scenarios that mimicked FR mouthbreathing showed exposure led to altered expression of genes whose products could be involved in lung ailments. Nevertheless, it was uncertain if repeated exposures (as occurred in earliest days post-disaster) might have given rise to long-term changes in the lungs/other organs, in white blood cell (WBC) profiles, and/or systemic expression of select (mostly immune-related) proteins. <b>Methods:</b> To examine this, rats were exposed on 2 consecutive days (2 hr/d, intratracheal inhalation) to WTC dusts and then examined over a 1-yr period thereafter. At select times post-exposure, organ (lung, heart, liver, kidney, spleen) weights, WBC profiles, and blood levels of a variety of proteins were evaluated. <b>Results:</b> The study showed that over the 1-yr period, there were nominal effects on organ weights (absolute, index) as a result of the dust exposures. There were significant changes (relative to in naïve rats) in WBC profiles, with exposed rats having increased monocyte-macrophage and decreased lymphocyte percentages. The study also found that dust exposure led to significant systemic increases in many proteins, including MCP-1, RANTES, MMP-9, RAGE, and Galectin-3. <b>Conclusions:</b> These results provide further support for our longstanding hypothesis that the WTC dusts could potentially have acted as direct inducers of many of the health effects that have been seen in the exposed FR.
DOI: 10.6084/m9.figshare.12366263
title: Table S2

description: Table S2 The sequence IDs in each Cluster<br> <br>
DOI: 10.6084/m9.figshare.12366257
title: Supplementary Material for: Natural Killer T Cells Are Numerically and Functionally Deficient in Patients with Trauma

description: Natural killer T (NKT) cells rapidly produce Th1 and Th2 cytokines such as interferon-γ (IFN-γ) and interleukin (IL)-4. This study examined the frequency and function of NKT cells in trauma patients. Frequencies, proliferative responses to α-galactosylceramide (α-GalCer), and Th1/Th2 cytokine secretion levels of NKT cells in peripheral blood mononuclear cells from trauma patients and healthy controls (HC) were measured by flow cytometry. Circulating NKT cell levels were significantly reduced in trauma patients. Proliferation and IFN-γ production of circulating NKT cells in response to α-GalCer were markedly decreased in trauma patients. CD69 expression levels produced by NKT cells were significantly upregulated in trauma patients compared to those in HC. In addition, annexin V+ NKT cells were profoundly increased in trauma patients after α-GalCer stimulation. Trauma patients had higher plasma levels of IL-6, IL-8, and TNF-α compared to HC. In particular, the proliferative response of NKT cells to α-GalCer was significantly decreased in the presence of these cytokines. Such decrease was partially recovered after treatment with blocking antibodies against these cytokines. This study demonstrates that circulating NKT cells are numerically deficient and functionally impaired in IFN-γ production in trauma patients. These findings provide an important insight into the trauma-related innate immune response.
DOI: 10.6084/m9.figshare.12366266.v1
title: Table S3

description: Table S3 The details information of the SNVs in all Clusters
DOI: 10.6084/m9.figshare.12366245
title: Dai and Karato Experimental Data.xlsx

description: Experimental Data
DOI: 10.6084/m9.figshare.12366248
title: Table S1

description: Table S1 The information of the first downloaded complete genome sequences<br>
DOI: 10.6084/m9.figshare.12366263.v1
title: Table S2

description: Table S2 The sequence IDs in each Cluster<br> <br>
DOI: 10.6084/m9.figshare.12366248.v1
title: Table S1

description: Table S1 The information of the first downloaded complete genome sequences<br>
DOI: 10.6084/m9.figshare.12366149
title: Supplementary Material for: Novel Coronavirus-Induced Right Ventricular Failure and Point of Care Echocardiography: A Case Report

description: Various cardiovascular complications have been reported in patients with coronavirus disease 2019. Common complications include acute myocardial injury, myocarditis, arrhythmia, pericarditis, heart failure, and shock. We present a case of cor pulmonale diagnosed with serial point of care ultrasound. Given the current shortage of personal protective equipment (PPE) and high infectivity of this virus, we acknowledge the utility of this tool in obtaining important clinical information while minimizing exposure and PPE consumption.
DOI: 10.6084/m9.figshare.12366077
title: Lake Michigan particle simulations

description: Particle simulations and drifter observations in the summers of 2014 and 2015
DOI: 10.6084/m9.figshare.12366077.v1
title: Lake Michigan particle simulations

description: Particle simulations and drifter observations in the summers of 2014 and 2015
DOI: 10.6084/m9.figshare.12366149.v1
title: Supplementary Material for: Novel Coronavirus-Induced Right Ventricular Failure and Point of Care Echocardiography: A Case Report

description: Various cardiovascular complications have been reported in patients with coronavirus disease 2019. Common complications include acute myocardial injury, myocarditis, arrhythmia, pericarditis, heart failure, and shock. We present a case of cor pulmonale diagnosed with serial point of care ultrasound. Given the current shortage of personal protective equipment (PPE) and high infectivity of this virus, we acknowledge the utility of this tool in obtaining important clinical information while minimizing exposure and PPE consumption.
DOI: 10.6084/m9.figshare.12366074
title: Monitoring seasonal variations in seismic velocity and groundwater levels in Harvey, Western Australia using borehole ambient seismic noise interferometry

description: This dataset is cross-correlation functions for EE, NN, ZZ and other cross-components. The file is saved by Python module Joblib.<br>
DOI: 10.6084/m9.figshare.12366029
title: 关于上海市社区泛在健康服务平台使用意愿及影响因素的调查问卷

description: 关于上海市社区泛在健康服务平台使用意愿及影响因素的调查问卷
DOI: 10.6084/m9.figshare.12366035
title: 关于高科技健康服务系统用户使用行为的调查问卷

description: 关于高科技健康服务系统用户使用行为的调查问卷
DOI: 10.6084/m9.figshare.12366038
title: Life traits for selected mammals

description: Body size, brain size, diet for a selected group of mammals
DOI: 10.6084/m9.figshare.12366074.v2
title: Monitoring seasonal variations in seismic velocity and groundwater levels in Harvey, Western Australia using borehole ambient seismic noise interferometry

description: This dataset is cross-correlation functions for EE, NN, ZZ and other cross-components. The file is saved by Python module Joblib.<br>
DOI: 10.6084/m9.figshare.12366038.v1
title: Life traits for selected mammals

description: Body size, brain size, diet for a selected group of mammals
DOI: 10.6084/m9.figshare.12366023
title: Summary adult suture patency

description: Summary of anatomical data related to suture patency in a sample of mammals.
DOI: 10.6084/m9.figshare.12366026
title: Specimens and suture patency

description: Specimens analyzed and their suture patency
DOI: 10.6084/m9.figshare.12366023.v1
title: Summary adult suture patency

description: Summary of anatomical data related to suture patency in a sample of mammals.
DOI: 10.6084/m9.figshare.12366074.v1
title: Monitoring seasonal variations in seismic velocity and groundwater levels in Harvey, Western Australia using borehole ambient seismic noise interferometry

description: This dataset is cross-correlation functions for EE, NN, ZZ and other cross-components. The file is saved by Python module Joblib.<br>Another zip file (Bunbury.zip) is temperature and rainfall data for Bunbury.
DOI: 10.6084/m9.figshare.12366026.v1
title: Specimens and suture patency

description: Specimens analyzed and their suture patency
DOI: 10.6084/m9.figshare.12366014
title: 上海市典型社区的健康服务特征数据

description: 上海市典型社区的健康服务特征数据
DOI: 10.6084/m9.figshare.12365483
title: Calibrated phylogeny of mammals

description: Phylogeny of mammalian species from http://www.timetree.org/
DOI: 10.6084/m9.figshare.12365483.v1
title: Calibrated phylogeny of mammals

description: Phylogeny of mammalian species from http://www.timetree.org/
DOI: 10.6084/m9.figshare.12365396
title: PLANILHA COLETA PROATIVA FINAL.xlsx

description: Dados relacionados a pesquisa epidemiológica em escolares de Paranavaí
DOI: 10.6084/m9.figshare.12365270
title: Additional file 4 of Hybrid simulation of pediatric gynecologic examination: a mix-methods study of learners’ attitudes and factors affecting learning

description: Additional file 4. The dataset supporting the conclusions of this article.
DOI: 10.6084/m9.figshare.12365270.v1
title: Additional file 4 of Hybrid simulation of pediatric gynecologic examination: a mix-methods study of learners’ attitudes and factors affecting learning

description: Additional file 4. The dataset supporting the conclusions of this article.
DOI: 10.6084/m9.figshare.12365252
title: Additional file 1 of Rural chronic disease research patterns in the United Kingdom, United States, Canada, Australia and New Zealand: a systematic integrative review

description: Additional file 1. Characteristics of included studies.
DOI: 10.6084/m9.figshare.12365252.v1
title: Additional file 1 of Rural chronic disease research patterns in the United Kingdom, United States, Canada, Australia and New Zealand: a systematic integrative review

description: Additional file 1. Characteristics of included studies.
DOI: 10.6084/m9.figshare.12365228
title: Additional file 7 of Melatonin may increase disease resistance and flavonoid biosynthesis through effects on DNA methylation and gene expression in grape berries

description: Additional file 7 Table S7 Primers used in this study.
DOI: 10.6084/m9.figshare.12365225
title: Additional file 6 of Melatonin may increase disease resistance and flavonoid biosynthesis through effects on DNA methylation and gene expression in grape berries

description: Additional file 6 Table S6 Alternative splicing frequency statistics for the control and melatonin-treated berries.
DOI: 10.6084/m9.figshare.12365228.v1
title: Additional file 7 of Melatonin may increase disease resistance and flavonoid biosynthesis through effects on DNA methylation and gene expression in grape berries

description: Additional file 7 Table S7 Primers used in this study.
DOI: 10.6084/m9.figshare.12365225.v1
title: Additional file 6 of Melatonin may increase disease resistance and flavonoid biosynthesis through effects on DNA methylation and gene expression in grape berries

description: Additional file 6 Table S6 Alternative splicing frequency statistics for the control and melatonin-treated berries.
DOI: 10.6084/m9.figshare.12365216
title: Additional file 4 of Melatonin may increase disease resistance and flavonoid biosynthesis through effects on DNA methylation and gene expression in grape berries

description: Additional file 4 Table S4 Cross-analysis of DMR-related genes and DEGs.
DOI: 10.6084/m9.figshare.12365219
title: Additional file 5 of Melatonin may increase disease resistance and flavonoid biosynthesis through effects on DNA methylation and gene expression in grape berries

description: Additional file 5 Table S5 Cross-analysis of DMP-related genes and DEGs.
DOI: 10.6084/m9.figshare.12365207
title: Additional file 2 of Melatonin may increase disease resistance and flavonoid biosynthesis through effects on DNA methylation and gene expression in grape berries

description: Additional file 2 Table S2 Differentially methylated regions (DMR, fold change ≥4 or ≤ 0.25, P
DOI: 10.6084/m9.figshare.12365213
title: Additional file 3 of Melatonin may increase disease resistance and flavonoid biosynthesis through effects on DNA methylation and gene expression in grape berries

description: Additional file 3 Table S3 Differentially expressed genes (DEGs) between the control and melatonin-treated berries (|log2FC| &gt; 1, P
DOI: 10.6084/m9.figshare.12365216.v1
title: Additional file 4 of Melatonin may increase disease resistance and flavonoid biosynthesis through effects on DNA methylation and gene expression in grape berries

description: Additional file 4 Table S4 Cross-analysis of DMR-related genes and DEGs.
DOI: 10.6084/m9.figshare.12365219.v1
title: Additional file 5 of Melatonin may increase disease resistance and flavonoid biosynthesis through effects on DNA methylation and gene expression in grape berries

description: Additional file 5 Table S5 Cross-analysis of DMP-related genes and DEGs.
DOI: 10.6084/m9.figshare.12365204
title: Additional file 1 of Melatonin may increase disease resistance and flavonoid biosynthesis through effects on DNA methylation and gene expression in grape berries

description: Additional file 1 Table S1 Details of the bisulfite sequencing, mapping and identification of methylated cytosines (mCs).
DOI: 10.6084/m9.figshare.12365207.v1
title: Additional file 2 of Melatonin may increase disease resistance and flavonoid biosynthesis through effects on DNA methylation and gene expression in grape berries

description: Additional file 2 Table S2 Differentially methylated regions (DMR, fold change ≥4 or ≤ 0.25, P
DOI: 10.6084/m9.figshare.12365213.v1
title: Additional file 3 of Melatonin may increase disease resistance and flavonoid biosynthesis through effects on DNA methylation and gene expression in grape berries

description: Additional file 3 Table S3 Differentially expressed genes (DEGs) between the control and melatonin-treated berries (|log2FC| &gt; 1, P
DOI: 10.6084/m9.figshare.12365195
title: Additional file 1 of Interleukin-6 deficiency exacerbates Huntington’s disease model phenotypes

description: Additional file 1: Supplementary materials.
DOI: 10.6084/m9.figshare.12365204.v1
title: Additional file 1 of Melatonin may increase disease resistance and flavonoid biosynthesis through effects on DNA methylation and gene expression in grape berries

description: Additional file 1 Table S1 Details of the bisulfite sequencing, mapping and identification of methylated cytosines (mCs).
DOI: 10.6084/m9.figshare.12365189
title: Additional file 3 of Interventions to improve adherence to antenatal and postnatal care regimens among pregnant women in sub-Saharan Africa: a systematic review

description: Additional file 3 Cochrane risk of bias determination.
DOI: 10.6084/m9.figshare.12365189.v1
title: Additional file 3 of Interventions to improve adherence to antenatal and postnatal care regimens among pregnant women in sub-Saharan Africa: a systematic review

description: Additional file 3 Cochrane risk of bias determination.
DOI: 10.6084/m9.figshare.12365195.v1
title: Additional file 1 of Interleukin-6 deficiency exacerbates Huntington’s disease model phenotypes

description: Additional file 1: Supplementary materials.
DOI: 10.6084/m9.figshare.12365129
title: Additional file 2 of A novel investigation of the effect of iterations in sliding semi-landmarks for 3D human facial images

description: Additional file 2. PCs scores for each iteration state.
DOI: 10.6084/m9.figshare.12365120
title: Additional file 1 of A novel investigation of the effect of iterations in sliding semi-landmarks for 3D human facial images

description: Additional file 1.Three-dimensional raw data for each iteration state.
DOI: 10.6084/m9.figshare.12365129.v1
title: Additional file 2 of A novel investigation of the effect of iterations in sliding semi-landmarks for 3D human facial images

description: Additional file 2. PCs scores for each iteration state.
DOI: 10.6084/m9.figshare.12365120.v1
title: Additional file 1 of A novel investigation of the effect of iterations in sliding semi-landmarks for 3D human facial images

description: Additional file 1.Three-dimensional raw data for each iteration state.