cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.20039244.v1
title: The radiation protection role of heparin-SOD conjugate in irradiated mice

description: ABSTRACT Heparin-SOD conjugate (Hep-SOD) was prepared by modifying Cu,Zn-SOD with heparin. An acute radiation-induced mouse injury model was constructed to study the radiation protection effects of Hep-SOD conjugate. Fifty-six mice were randomly divided into seven groups: (I) normal control group; (II) irradiated control group; (III) positive control group (amifostine group, 300 mg/kg); (IV) SOD group (35000 U/kg); (V) high dosage of Hep-SOD group (70000 U/kg); (VI) medium dosage of Hep-SOD group (35000 U/kg); (VII) low dosage of Hep-SOD group (17500 U/kg). Drugs were intraperitoneally injected into each mouse 1 h before radiation except for the normal control group. All the irradiated groups were irradiated with 6 Gy. Organ indices, haematopoietic function indices, peripheral blood cells, liver function test, oxidative stress state and pathological observation were detected to study the effects of Hep-SOD on irradiated mice. Results showed that bone marrow suppression of irradiated mice could be reduced when treated by Hep-SOD before radiation. Oxidative stress detection and pathological observation of the liver and intestine showed that the damage caused by radiation was relieved when mice were treated with Hep-SOD before radiation. This study shows a new direction to prevent organisms from the damage caused by radiation.
DOI: 10.6084/m9.figshare.7980974
title: Additional file 1: of Analysis of long non-coding RNAs in neonatal piglets at different stages of porcine deltacoronavirus infection

description: The target geneÂ of lncRNAs. (XLSX 238 kb)
DOI: 10.6084/m9.figshare.7980974.v1
title: Additional file 1: of Analysis of long non-coding RNAs in neonatal piglets at different stages of porcine deltacoronavirus infection

description: The target geneÂ of lncRNAs. (XLSX 238 kb)
DOI: 10.6084/m9.figshare.7980983
title: Additional file 2: of Analysis of long non-coding RNAs in neonatal piglets at different stages of porcine deltacoronavirus infection

description: Gene ontology (GO) analysis of target genes. (XLSX 10 kb)
DOI: 10.6084/m9.figshare.20039415
title: Solid dispersion-based pellet for colon delivery of tacrolimus through time- and pH-dependent layer coating: preparation, in vitro and in vivo studies

description: The intent of the present investigation is to develop and evaluate colon-specific coated tacrolimus solid dispersion pellet (SDP) that retards drug release in the stomach and small intestine but progressively releases in the colon. Tacrolimus-SDP was prepared by extrusion-spheronization technology and optimized by the micromeritic properties including flowability, friability, yields and dissolution rate. Subsequently, the pH-dependent layer (Eudragit L30D55) and time-dependent layer (Eudragit NE30D and L30D55) were coated on the SDP to form tacrolimus colon-specific pellets (CSP) using a fluidized bed coater. Under in vitro gradient pH environment, tacrolimus only released from CSP after changing pH to 6.8 and then quickly released in the phosphate buffer solution of pH 7.2. The Cmax of CSP was 195.68 ± 3.14 ng/mL at Tmax 4.5 ± 0.24 h where as in case of SDP, the Cmax was 646.16 ± 8.15 ng/mL at Tmax 0.5 ± 0.03 h, indicating the ability of CSP targeted to colon. The highest area under the curve was achieved 2479.58 ± 183.33 ng·h/mL for SDP, which was 2.27-fold higher than tacrolimus suspension. However, the best biodistribution performance was achieved from CSP. In conclusion, SDP combining of pH- and time-dependent approaches was suitable for targeted delivery of tacrolimus to colon.
DOI: 10.6084/m9.figshare.20039415.v1
title: Solid dispersion-based pellet for colon delivery of tacrolimus through time- and pH-dependent layer coating: preparation, in vitro and in vivo studies

description: The intent of the present investigation is to develop and evaluate colon-specific coated tacrolimus solid dispersion pellet (SDP) that retards drug release in the stomach and small intestine but progressively releases in the colon. Tacrolimus-SDP was prepared by extrusion-spheronization technology and optimized by the micromeritic properties including flowability, friability, yields and dissolution rate. Subsequently, the pH-dependent layer (Eudragit L30D55) and time-dependent layer (Eudragit NE30D and L30D55) were coated on the SDP to form tacrolimus colon-specific pellets (CSP) using a fluidized bed coater. Under in vitro gradient pH environment, tacrolimus only released from CSP after changing pH to 6.8 and then quickly released in the phosphate buffer solution of pH 7.2. The Cmax of CSP was 195.68 ± 3.14 ng/mL at Tmax 4.5 ± 0.24 h where as in case of SDP, the Cmax was 646.16 ± 8.15 ng/mL at Tmax 0.5 ± 0.03 h, indicating the ability of CSP targeted to colon. The highest area under the curve was achieved 2479.58 ± 183.33 ng·h/mL for SDP, which was 2.27-fold higher than tacrolimus suspension. However, the best biodistribution performance was achieved from CSP. In conclusion, SDP combining of pH- and time-dependent approaches was suitable for targeted delivery of tacrolimus to colon.
DOI: 10.6084/m9.figshare.20039649
title: Curcumin solid dispersion based on three model acrylic polymers: formulation and release properties

description: Abstract To investigate structure-property relationship of polymer-based curcumin solid dispersion (SD), three acrylic polymers were used to formulate curcumin SD by solvent evaporation method. Curcumin Eudragit EPO SD (cur@EPO), curcumin Eudragit RS PO SD (cur@RSPO) and curcumin Eudragit RL PO SD (cur@RLPO) showed deep red, golden orange and reddish orange color, respectively. Cur@RSPO entrapped 15.42 wt% of curcumin followed by cur@RL PO and cur@EPO. FTIR spectra indicated that in cur@EPO, curcumin may transfer hydrogen to the dimethylaminoethyl methacrylate group and thus change its color to red. In contrast, curcumin may form hydrogen bonding with Eudragit RS PO and Eudragit RL. Curcumin exists in amorphous state in three SDs as proved by differential scanning calorimetry and X-Ray diffraction measurement. In vitro digestion presented that lower pH value in simulated gastric ﬂuid (SGF) stimulates the curcumin release from cur@EPO while permeability inﬂuences the release profile in other two SDs. When in simulated intestinal ﬂuid (SIF), first order release model governs the release behaviors of all three SDs which showed sustained release pattern. Our results are helpful to elucidate how structure of polymer may impact on the major properties of curcumin contained SD and will be promising to broaden its therapeutic applications.
DOI: 10.6084/m9.figshare.20039651.v1
title: Comparative stomach tissue distribution profiles of four major bio-active components of Radix Astragali in normal and gastric ulcer mice

description: Abstract Numerous studies have demonstrated that Radix Astragali can inhibit gastric ulcers in mice. Anhydrous ethanol (0.01 mL/g) administered to mice by intragastric infusion can induce gastric ulcer injury. This study was performed to compare the stomach tissue distribution profiles of four major bioactive constituents of Radix Astragali(calycosin-7-O-β-d-glucoside, calycosin, ononin and formononetin) after oral administration of extract of Radix Astragali (ERA)in normal and gastric ulcer mice. The abundance of Radix Astragali constituents was determined using an ultra-pressure liquid chromatograph with a photodiode array detector (UPLC-PDA), after which histograms were drawn. In comparison with normal mice, the contents of calycosin- 7-O-β-d-glucoside, calycosin, ononin and formononetin in the stomach tissue samples of gastric ulcer mice showed significant differences at the selected time points (P &lt; 0.05).The abundance of each of the four tested constituents in the normal groups was higher than that of the gastric ulcer groups. This study provides an empirical foundation for future studies focused on developing clinical applications of Radix Astragali.
DOI: 10.6084/m9.figshare.20039651
title: Comparative stomach tissue distribution profiles of four major bio-active components of Radix Astragali in normal and gastric ulcer mice

description: Abstract Numerous studies have demonstrated that Radix Astragali can inhibit gastric ulcers in mice. Anhydrous ethanol (0.01 mL/g) administered to mice by intragastric infusion can induce gastric ulcer injury. This study was performed to compare the stomach tissue distribution profiles of four major bioactive constituents of Radix Astragali(calycosin-7-O-β-d-glucoside, calycosin, ononin and formononetin) after oral administration of extract of Radix Astragali (ERA)in normal and gastric ulcer mice. The abundance of Radix Astragali constituents was determined using an ultra-pressure liquid chromatograph with a photodiode array detector (UPLC-PDA), after which histograms were drawn. In comparison with normal mice, the contents of calycosin- 7-O-β-d-glucoside, calycosin, ononin and formononetin in the stomach tissue samples of gastric ulcer mice showed significant differences at the selected time points (P &lt; 0.05).The abundance of each of the four tested constituents in the normal groups was higher than that of the gastric ulcer groups. This study provides an empirical foundation for future studies focused on developing clinical applications of Radix Astragali.
DOI: 10.6084/m9.figshare.18462051
title: Additional file 1 of Development of a europium nanoparticles lateral flow immunoassay for NGAL detection in urine and diagnosis of acute kidney injury

description: zip
DOI: 10.6084/m9.figshare.7981031
title: MOESM13 of Construction and comprehensive analysis of a ceRNA network to reveal potential prognostic biomarkers for hepatocellular carcinoma

description: Additional file 13. R code.
DOI: 10.6084/m9.figshare.20039628
title: Blood glucose related adverse drug reaction of antitumor monoclonal antibodies: a retrospective analysis using Vigibase

description: Abstract On the increasing prevalence of using mAbs (monoclonal antibodies) in cancer therapy and the severe risk of hyperglycemia, we aimed to analyze the main clinical ADRs of mAbs, with a focus on adverse hyperglycemic events associated with currently clinically used mAbs. mAbs as well as target information were selected from Martinadale book and published articles. Drug approving information was collected from each government website, and ADR statistic data were collected from VigibaseR, comparing with Adverse Event Reporting System of US FDA. Top 10 mAbs were classified within listing in total ADR records, ADRs per year, hyperglycemic ADR records. Vigibase data were updated onto 15 Feb 2019. 20 mAbs were analyzed with 263217 ADR reports, wherein 16751 records on Metabolism and nutrition disorders and 1444 records on Glucose metabolism disorders. The geographic, age, gender distributions and annual ADR report numbers were listed respectively. Of the top 10, Rituximab, Bevacizumab and Nivolumab were on the top 3 in total ADR record and hyperglycemic record. Top 3 record results were similar in Vigibase and FDA database. It is of increasing importance for clinicians to be aware of early detection, patient management, or drug selection strategies when using mAbs, particularly within the high glycemic risk-reported mAbs, to improve the efficacy and tolerability of mAbs regiment and optimize patient outcomes.
DOI: 10.6084/m9.figshare.20039562.v1
title: Polymer blend: a new approach for eliminating curing effect of aqueous dispersion coatings

description: The aim of present work was to investigate blends of Eudragit® NE 30D with Aquacoat® ECD using different ratios to eliminate curing effect associated with individual polymers. Propranolol HCl 10% w/w was layered onto sugar cores using 5% w/w HPMC as a binder. Drug-layered-cores were coated either with pure or blends of Aquacoat® ECD: Eudragit® NE 30D in a fluidized bed coater to obtain 20% w/w coating level. Talc 35% w/w was used as anti-tacking agent. The pellets were characterized for in vitro dissolution studies, morphology, water uptake-weight loss, osmolality and adhesion of coating after curing at 60 °C or 60 °C/75% RH for 24 h. The findings revealed that Aquacoat® ECD coated pellets showed curing effect due to further gradual coalescence of polymeric particles which resulted into better film formation upon curing. In contrast, the curing effect of Eudragit® NE 30D coated pellets was caused by decrease in adhesion of coatings after curing which provided entirely different swelling behavior of uncured (localized swelling) and cured (uniform swelling) pellets. The undesired curing effect of individual polymers was eliminated by using their blends in appropriate ratio.
DOI: 10.6084/m9.figshare.20039628.v1
title: Blood glucose related adverse drug reaction of antitumor monoclonal antibodies: a retrospective analysis using Vigibase

description: Abstract On the increasing prevalence of using mAbs (monoclonal antibodies) in cancer therapy and the severe risk of hyperglycemia, we aimed to analyze the main clinical ADRs of mAbs, with a focus on adverse hyperglycemic events associated with currently clinically used mAbs. mAbs as well as target information were selected from Martinadale book and published articles. Drug approving information was collected from each government website, and ADR statistic data were collected from VigibaseR, comparing with Adverse Event Reporting System of US FDA. Top 10 mAbs were classified within listing in total ADR records, ADRs per year, hyperglycemic ADR records. Vigibase data were updated onto 15 Feb 2019. 20 mAbs were analyzed with 263217 ADR reports, wherein 16751 records on Metabolism and nutrition disorders and 1444 records on Glucose metabolism disorders. The geographic, age, gender distributions and annual ADR report numbers were listed respectively. Of the top 10, Rituximab, Bevacizumab and Nivolumab were on the top 3 in total ADR record and hyperglycemic record. Top 3 record results were similar in Vigibase and FDA database. It is of increasing importance for clinicians to be aware of early detection, patient management, or drug selection strategies when using mAbs, particularly within the high glycemic risk-reported mAbs, to improve the efficacy and tolerability of mAbs regiment and optimize patient outcomes.
DOI: 10.6084/m9.figshare.20039498.v1
title: Evaluation of antiarthritic activity of ginkgolic acid against Freund’s adjuvant induced arthritic rat model

description: This study aimed to analyze the antiarthritic activity of ginkgolic acid against the Complete Freund’s Adjuvant (CFA)-induced arthritis in rats. Arthritis was induced through an intradermal injection of CFA (0.1 mL) at the right hind footpad of adult Wistar Albino rats. Ginkgolic acid was administered orally at doses of 25 mg/kg and 50 mg/kg, respectively, once daily via gavage for 25 days upon inducing arthritis. Indomethacin was administered orally at a dose of 3 mg/kg twice in a week which served as positive control group. The animals were sacrificed and subjected to biochemical and histopathological analysis upon completion of treatment. Ginkgolic acid was able to reverse the arthritic effect (p &lt; 0.01) induced by CFA in a dose dependent manner. Swelling of paw, thymus and spleen index, serum biomarker levels, and pro-inflammatory cytokines were significantly reduced (p &lt; 0.01) by the acid whereas the antioxidant enzyme activities were remarkably restored. The histopathological findings were in agreement with the biochemical results. The results indicate that the antioxidant and anti-inflammatory properties of ginkgolic acid can be credited to the antiarthritic effects, and it can be promoted as a potential agent for therapeutic use against osteoarthritis.
DOI: 10.6084/m9.figshare.20039649.v1
title: Curcumin solid dispersion based on three model acrylic polymers: formulation and release properties

description: Abstract To investigate structure-property relationship of polymer-based curcumin solid dispersion (SD), three acrylic polymers were used to formulate curcumin SD by solvent evaporation method. Curcumin Eudragit EPO SD (cur@EPO), curcumin Eudragit RS PO SD (cur@RSPO) and curcumin Eudragit RL PO SD (cur@RLPO) showed deep red, golden orange and reddish orange color, respectively. Cur@RSPO entrapped 15.42 wt% of curcumin followed by cur@RL PO and cur@EPO. FTIR spectra indicated that in cur@EPO, curcumin may transfer hydrogen to the dimethylaminoethyl methacrylate group and thus change its color to red. In contrast, curcumin may form hydrogen bonding with Eudragit RS PO and Eudragit RL. Curcumin exists in amorphous state in three SDs as proved by differential scanning calorimetry and X-Ray diffraction measurement. In vitro digestion presented that lower pH value in simulated gastric ﬂuid (SGF) stimulates the curcumin release from cur@EPO while permeability inﬂuences the release profile in other two SDs. When in simulated intestinal ﬂuid (SIF), first order release model governs the release behaviors of all three SDs which showed sustained release pattern. Our results are helpful to elucidate how structure of polymer may impact on the major properties of curcumin contained SD and will be promising to broaden its therapeutic applications.
DOI: 10.6084/m9.figshare.7980983.v1
title: Additional file 2: of Analysis of long non-coding RNAs in neonatal piglets at different stages of porcine deltacoronavirus infection

description: Gene ontology (GO) analysis of target genes. (XLSX 10 kb)
DOI: 10.6084/m9.figshare.14715176.v2
title: Additional file 9 of Highly recurrent CBS epimutations in gastric cancer CpG island methylator phenotypes and inflammation

description: Additional file 9: Table S8. CBS germline and somatic genetic mutations in the gastric TCGA cohort.
DOI: 10.6084/m9.figshare.19516299
title: Proprioceptive feedback design for gait synchronization in collective undulatory robots

description: The collective movement of animals has long been a source of inspiration for multi-agent swarm robotics. One of the fundamental goals for swarm robotics study is to understand how effective and robust collective behaviors can emerge from simple interaction principles. When animal or robot collectives are in high-density configurations the ability for visual or auditory sensing is diminished and the opportunities for interacting through mechanical contact are enhanced. In this paper, we study how robots that move through lateral body undulation in close proximity are capable of synchronizing their oscillatory gaits through contact interactions between adjacent robots. Critically, gait phase synchronization occurs without the requirement for robot–robot communication, and instead can be engineered as an emergent property of the robot control system. We present a proprioceptive feedback control system that generates collective gait phase synchronization of undulatory robots in experiment and simulation. We first validate this control system using a simple one-dimensional toy model to demonstrate how proprioceptive feedback governs phase synchronization. Simulations and experiments with undulatory three-link robots further demonstrate how phase synchronization can be controlled. Lastly, we demonstrate that robot pairs moving in a confined tunnel can synchronize their movements which leads to faster group locomotion through confined spaces.
DOI: 10.6084/m9.figshare.14266956
title: Additional file 2 of Prevention of acquired sensorineural hearing loss in mice by in vivo Htra2 gene editing

description: Additional file 2. The results of HTS.
DOI: 10.6084/m9.figshare.14266971.v1
title: Additional file 7 of Prevention of acquired sensorineural hearing loss in mice by in vivo Htra2 gene editing

description: Additional file 7. The list of primer sequence.
DOI: 10.6084/m9.figshare.6933494.v1
title: MOESM1 of Cecal microbiome profile altered by Salmonella enterica, serovar Enteritidis inoculation in chicken

description: Additional file 1. Data assessment and number of OTUs for each sample.
DOI: 10.6084/m9.figshare.10086470
title: MOESM3 of Inflammatory responses to a pathogenic West Nile virus strain

description: Additional file 3. nCounter panel data. (A) Time course of infection experiments in SK-N-SH cells given as a ratio relative to uninfected cells (day 0). Pathway scores used for heat-map generated from nCounter panels of infected (B) SK-N-SH and (C) neuronal cells.
DOI: 10.6084/m9.figshare.10086470.v1
title: MOESM3 of Inflammatory responses to a pathogenic West Nile virus strain

description: Additional file 3. nCounter panel data. (A) Time course of infection experiments in SK-N-SH cells given as a ratio relative to uninfected cells (day 0). Pathway scores used for heat-map generated from nCounter panels of infected (B) SK-N-SH and (C) neuronal cells.
DOI: 10.6084/m9.figshare.10086488
title: MOESM5 of Inflammatory responses to a pathogenic West Nile virus strain

description: Additional file 5. Differential analysis data.
DOI: 10.6084/m9.figshare.10086488.v1
title: MOESM5 of Inflammatory responses to a pathogenic West Nile virus strain

description: Additional file 5. Differential analysis data.
DOI: 10.24403/jp.1336403
title: Die Naturschutzgebiete Sachsen-Anhalts, Hrsg. vom Landesamt für Umweltschutz Sachsen-Anhalt. - Jena ; Stuttgart ; Lübeck ; Ulm : Gustav Fischer Verlag, 1997. / [rezensiert von] H. Manitz
DOI: 10.6084/m9.figshare.10086713
title: MOESM1 of Inheritance of pre-emergent metribuzin tolerance and putative gene discovery through high-throughput SNP array in wheat (Triticum aestivum L.)

description: Additional file 1: Table S1. The SNPâ s and their alleles in tolerant and susceptible bulk.
DOI: 10.6084/m9.figshare.10086713.v1
title: MOESM1 of Inheritance of pre-emergent metribuzin tolerance and putative gene discovery through high-throughput SNP array in wheat (Triticum aestivum L.)

description: Additional file 1: Table S1. The SNPâ s and their alleles in tolerant and susceptible bulk.
DOI: 10.24403/jp.1336405
title: Ochyra, R.: The moss flora of King George Island, Antarctica. - Cracow : Polish Academy of Sciences, W. SZAFER Institute of Botany, 1998 / [rezensiert von] H.-J. Zündorf
DOI: 10.24403/jp.1336407
title: Orchideen in Thüringen, Hrsg. vom Arbeitskreis Heimische Orchideen Thüringen e.V., Uhlstädt 1997. / [rezensiert von] F. K. Meyer
DOI: 10.6084/m9.figshare.10086947
title: MOESM1 of Network vulnerability-based and knowledge-guided identification of microRNA biomarkers indicating platinum resistance in high-grade serous ovarian cancer

description: Additional file 1. Differentially expressed miRNAs between platinum-resistant and platinum-sensitive HGSC patients.
DOI: 10.6084/m9.figshare.10086956
title: MOESM2 of Network vulnerability-based and knowledge-guided identification of microRNA biomarkers indicating platinum resistance in high-grade serous ovarian cancer

description: Additional file 2. Differentially expressed mRNAs between platinum-resistant and platinum-sensitive HGSC patients.
DOI: 10.6084/m9.figshare.10086956.v1
title: MOESM2 of Network vulnerability-based and knowledge-guided identification of microRNA biomarkers indicating platinum resistance in high-grade serous ovarian cancer

description: Additional file 2. Differentially expressed mRNAs between platinum-resistant and platinum-sensitive HGSC patients.
DOI: 10.6084/m9.figshare.10086962
title: MOESM3 of Network vulnerability-based and knowledge-guided identification of microRNA biomarkers indicating platinum resistance in high-grade serous ovarian cancer

description: Additional file 3. The PRMNH composed by differentially expressed miRNAs and mRNAs.
DOI: 10.6084/m9.figshare.10086962.v1
title: MOESM3 of Network vulnerability-based and knowledge-guided identification of microRNA biomarkers indicating platinum resistance in high-grade serous ovarian cancer

description: Additional file 3. The PRMNH composed by differentially expressed miRNAs and mRNAs.