cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.7710674.v1
title: A predictive model to distinguish malignant and benign thyroid nodules based on age, gender and ultrasonographic features

description: Abstract Introduction: A discussion in literature about a standardized decision support tool for the management of thyroid nodules remains. Objective: The purpose of this study was to create a statistical prediction model for thyroid nodules management. Methods: Two hundred and four benign and 57 malignant thyroid nodules were selected for a retrospective study. The variables age, gender and ultrasonographic features were examined using univariate and multivariate models. A statistical formula was used to calculate the risk of cancer of each case. Results: In multivariate analysis, irregular shape, absence of halo, lower mean age, homogeneous echotexture, microcalcifications and solid content were associated with cancer. After applying the formula, 20 cases (7.6%) with a calculated risk for malignancy ≤3.0% were found, all of them benign. Setting the calculated risk in ≥80%, 21 (8.0%) cases were selected, and in 85.7% of them cancer was confirmed in histopathology. Internal accuracy of the prediction formula was 92.5%. Conclusions: The prediction formula reached high accuracy and may be an alternative to other decision support tools for thyroid nodule management.
DOI: 10.6084/m9.figshare.16750633.v1
title: Phenotypic space and performance of Juniperus thurifera across woodland-expanding areas

description: Leaf and plant-size traits of 180 juveniles of Juniperus thurifera across a woodalnd expasion gradient. Growth rate, resilience to drought and environmental variables are also included. Related paper: Benavides, R., Acuña-Míguez, B., Valladares, F. <strong>Early differentiation of the phenotypic space and performance of </strong><em><strong>Juniperus thurifera</strong></em><strong> across woodland-expanding areas</strong> Ecosystems (in press)<br>
DOI: 10.17632/ctw3xg6g9s
title: Trem2 prevents adverse pregnancy outcomes induced by Toxoplasma gondii by promoting PPARγ-mediated P-STAT6 signaling

description: Decidual macrophages (DMs), required for the maintenance of a successful pregnancy, are vital target cells for Toxoplasma gondii (T. gondii) during adverse pregnancy induced by T. gondii. Trem2 is a functional immune receptor on the surface of DMs, governing cell survival and phagocytosis. The role of Trem2 and its downstream signaling pathways in T. gondii-induced adverse pregnancy outcomes remains unclear. Here, we demonstrated a significant decrease in Trem2 expression on DMs following T. gondii infection. By using a knockout mouse model, we found that Trem2-deficiency resulted in more severe adverse pregnancy outcomes as compared to the mock controls. Additionally, compelling evidence from animal models and in vitro cell experiments indicated that T. gondii downregulated PPARγ and phosphorylated-STAT6 (P-STAT6). In addition, Trem2-deficiency led to weakened macrophage responses to T. gondii antigens (TgAg) in both peritoneal macrophages and bone marrow-derived macrophages (BMDMs). Consistently, overexpression of Trem2 in macrophages significantly activated the downstream signaling pathway and partially reversed the inhibitory effects of TgAg on P-STAT6 and PPARγ, similar to the effect of PPARγ agonists. Altogether, our study identified Trem2 as a key factor implicated in the pathomechanism of adverse pregnancy outcomes due to T. gondii infection. Our novel findings in regard to Trem2 and its downstream PPARγ and STAT6 signaling pathways might provide new preventive and therapeutic targets for toxoplasmosis.
DOI: 10.17632/tr39xmkfbp
title: Data for: Implementation of exclusion devices to mitigate seal (Arctocephalus australis, Otaria flavescens) incidental mortalities during bottom-trawling in the Falkland Islands (Southwest Atlantic)

description: The files uploaded include working tables related to the bycatch mitigation and outcomes (Table A.1); seal exclusion device (SED) trials with problems encountered and how they were solved (Table A.2); square mesh net barrier trials (Table A.3); underwater footage analysed (Table A.4) and the current license conditions regarding SED requirements (Fig.A.1).
DOI: 10.4121/14626020.v1
title: Process Discovery Contest 2020

description: This is the data set that was used for the Process Discovery Contest of 2020 (PDC 2020). The data set contains 192 training logs, 192 corresponding test logs, 192 corresponding ground truth logs, and 96 models. The logs are all stored using the IEEE XES file format (see either https://www.xes-standard.org/ or https://ieeexplore.ieee.org/document/7740858), while the models are workflow nets (a subclass of Petri nets) stored in the PNML file format (see<br>https://www.iso.org/obp/ui/#iso:std:iso-iec:15909:-2:ed-1:v1:en).<br>
DOI: 10.6084/m9.figshare.28522049.v1
title: Supplementary Material for: Optimal Low Dose Synacthen Stimulation Test Sampling Time for Diagnosis of Adrenal Insufficiency Using Monoclonal Antibody Immunoassay

description: Context: The low-dose synacthen stimulation test (LDSST) evaluates hypothalamo-pituitary-adrenal axis function. However, studies on the correlation between morning basal and stimulated cortisol concentrations using specific monoclonal antibody immunoassays during LDSST are limited.
Objective: To determine the best time points and sampling approach for cortisol measurement using mAb immunoassay in children during LDSST.
Design and Setting: Morning basal and stimulated serum cortisol measurements in the LDSST were prospectively analysed in 132 children (61 girls) with clinical suspicion of adrenal insufficiency (AI).
Methods: Serum cortisol concentrations were assessed at 0, 30, 40, and 60th minutes during LDSST using mAb immunoassay. Simultaneously, morning basal cortisol levels in 119 patients were measured with both mAb immunoassay and liquid chromatography-mass spectrometry. Adrenal insufficiency (AI) was defined by a peak plasma cortisol concentration below 18 μg/dL (500 nmol/L).
Results: Adrenal insufficiency (AI) was excluded in 80.3% (n=106) of patients. The 40th minute showed the highest specificity (89.1%) for predicting LDSST outcomes with a single cortisol measurement. For two time-point measurements, the 40th and 60th minutes were significantly more sensitive than other possibilities (p&lt;0.001). A morning basal cortisol level below 6.5 μg/dL was identified as predictive of a failed LDSST result. 
Conclusions: In LDSST, measurement of plasma cortisol at 40th and 60th minutes reduces the risk of false positivity. Single sampling at 40th minute yielded fewer false negatives than sampling at 30th or 60th minute.
DOI: 10.17632/kvdzcvy8xr
title: Data for: A low distortion conformal projection of a tri-axial ellipsoid and its application for mapping of extra-terrestrial objects

description: There are 4 *.m files with computer program for creation of Chebyshev projection of a triaxial ellipsoid and one text file with data (boundary points of Stickney crater). Longitude is substracted from 360 degrees.
DOI: 10.17632/r2k54rr5p2
title: Hydraulic conductivity measurements of aquitard sediments in the Netherlands

description: Hydrogeological dataset for sediment samples, including hydraulic conductivity, grain size distribution, organic carbon content, carbonate content, estimated chloride concentration and geological and sedimentological information. Excerpt from TOPINTEGRAAL dataset from June 1, 2023, complemented with additional parameters related to the samples. This dataset is used for van Leer, M.D., Zaadnoordijk, W.J., Zech, A., Buma, J., Harting, R., Bierkens, M.F.P., & Griffioen, J. (2023) [Submitted for publication]. An overview of the methodology used to produce this dataset can be found in the paper.
DOI: 10.6084/m9.figshare.5123635.v1
title: Supplementary Material for: One-Year Change in Kidney Function Is Associated with an Increased Mortality Risk

description: <b><i>Background:</i></b> Serum creatinine is routinely measured to estimate glomerular filtration rate (GFR). Long-term cohort studies report that death is a likelier outcome than progression to kidney failure. However, it is unclear how short-term changes in estimated GFR (eGFR) over a 1-year period relate to subsequent mortality risk. <b><i>Methods:</i></b> Using a provincial laboratory registry from Alberta, Canada, we identified 598,397 adults who had ≥2 outpatient eGFR measurements at least 6 months apart during a 1-year accrual period. Change in kidney function was categorized by both changes in eGFR category and percent change ≥25% into 5 groups: certain drop, uncertain drop, stable (no change in CKD category), uncertain rise, and certain rise. Cox proportional hazards models, adjusting for baseline covariates, kidney function, and proteinuria were used to estimate the risk of all-cause mortality associated with each group change in kidney function in reference to stable kidney function. <b><i>Results:</i></b> Among the study participants, 447,570 (74.8%) had stable kidney function, 19,591 (3.3%) had a certain drop, and 22,171 (3.7%) had a certain rise in kidney function. Participants with change in kidney function (both drop and rise) were older, more likely to be female, and had a higher prevalence of comorbidities in comparison to those with stable kidney function. There were 51,473 (8.6%) deaths during a median follow-up of 3.5 years. Compared to participants with stable kidney function, those with a certain drop had an almost twofold increased mortality risk (hazard ratio 1.89, 95% CI 1.83–1.95) adjusted for baseline eGFR, proteinuria, and covariates. Participants with a certain rise (3.7%) in kidney function also experienced an increased mortality risk (hazard ratio 1.51, 95% CI 1.46–1.56) compared to those with stable kidney function. Risk of death was similarly increased with adjustment for eGFR at the last visit. <b><i>Conclusion:</i></b> Change in kidney function of ≥25% in any direction over a 1-year period is associated with a substantially increased risk of mortality.
DOI: 10.6084/m9.figshare.11567907.v1
title: Supplementary Material for: Combining Serum Cystatin C and Urinary N-Acetyl-Beta-D-Glucosaminidase Improves the Precision for Acute Kidney Injury Diagnosis after Resection of Intracranial Space-Occupying Lesions

description: <b><i>Background:</i></b> Postoperative acute kidney injury (AKI) is frequent and associated with adverse outcomes. Unfortunately, the early diagnosis of AKI remains a challenge. Combining functional and tubular damage biomarkers may provide better precision for AKI detection. However, the diagnostic accuracy of this combination for AKI after neurosurgery is unclear. Serum cystatin C (sCysC) and urinary albumin/creatinine ratio (uACR) are considered functional biomarkers, while urinary N-acetyl-β-D-glucosaminidase (uNAG) represents tubular damage. We aimed to assess the performances of these clinical available biomarkers and their combinations for AKI prediction after resection of intracranial space-occupying lesions. <b><i>Methods:</i></b> A prospective study was conducted, enrolling adults undergoing resection of intracranial space-occupying lesions and admitted to the neurosurgical intensive care unit. The discriminative abilities of postoperative sCysC, uNAG, uACR, and their combinations in predicting AKI were compared using the area under the receiver operating characteristic curve (AUC-ROC), continuous net reclassification index (cNRI), and incremental discrimination improvement (IDI). <b><i>Results:</i></b> Of 605 enrolled patients, AKI occurred in 67 patients. The cutoff values of sCysC, uNAG, and uACR to predict postoperative AKI were 0.72 mg/L, 19.98 U/g creatinine, and 44.21 mg/g creatinine, respectively. For predicting AKI, the composite of sCysC and uNAG (AUC-ROC = 0.785) outperformed either individual biomarkers or the other two panels (uNAG plus uACR or sCysC plus uACR). Adding this panel to the predictive model improved the AUC-ROC to 0.808. Moreover, this combination significantly improved risk reclassification over the clinical model alone, with cNRI (0.633) and IDI (0.076). Superior performance of this panel was further confirmed with bootstrap internal validation. <b><i>Conclusions:</i></b> Combination of functional and tubular damage biomarkers improves the predictive accuracy for AKI after resection of intracranial space-occupying lesions.
DOI: 10.6084/m9.figshare.778538.v1
title: Gaussian Job Archive for C15H16N2O2S

description: Archive of work produced using the resources of the Imperial College High Performance Computing Service.
DOI: 10.6084/m9.figshare.27160689.v1
title: wisn_data.docx

description: <b>Unveiling efficiency: A research inquiry into technical staff utilization in South Indian clinical laboratory using workload indicators staffing need (WSN) analysis</b><b>. </b>(https://doi.org/10.12688/f1000research.152755.1<b>)</b><br><br>
DOI: 10.6084/m9.figshare.28684595.v2
title: Figure 5 image source for hCRAFi-CCR2

description: <b>Figure 5. </b><b>a</b>. Representative single-plane confocal images of hCRAFi-CCR2-transfected HEK cells incubated in mouse plasma before (no MK-0812) and after treatment with CCR2 antagonist MK-0812 . Mouse plasma for each group was collected after treatment with LPS (2 mg/kg) for 0 (Ctrl), 6, and 24 hours
DOI: 10.6084/m9.figshare.21197440.v1
title: Genotypic and phenotypic datasets from Iranian bread wheat collection

description: Supplementary datasets in the following paper: <strong>GWAS to identify genomic loci associated with early vigour in bread wheat under simulated water deficit complemented with QTL meta-analysis</strong>
DOI: 10.6084/m9.figshare.28760201.v1
title: Prediction uploaded on the afternoon of April 9th regarding the Barcellona vs Borussia Dortmund match taking place later that same evening.

description: Further details about the study are available at the following links:<br>https://osf.io/pcwah<br>https://osf.io/xsb9t
DOI: 10.17632/kvtryf67vg
title: Transcriptional Circuit Fragility Influences HIV Proviral Fate

description: Mathematical modeling of a complete HIV transcriptional circuit
DOI: 10.17632/vb6f9d6dk8
title: Data for: On the Molecular Determinants of the SARS-CoV-2 Attack

description: Molecular Determinants and Mechanism of the SARS-CoV-2 Attack
DOI: 10.25403/upresearchdata.27678954.v1
title: Relationship between decent work and job satisfaction amongst blue-collar workers : exploring the potential mediating and moderating effects of psychological ownership

description: The study bridged the gap by exploring the relationships between decent work, job satisfaction and psychological ownership and by investigating the direct, indirect and moderating effect of psychological ownership on the relationship between decent work and job satisfaction. Understanding these dynamics is crucial for developing targeted interventions and policies that improve working conditions and job satisfaction among blue-collar workers in the context of South Africa’s unique socioeconomic and cultural environment. The study employed a quantitative cross-sectional survey design using a convenience sample of 628 participants from a South African truck trailer manufacturing company, achieving a response rate of 78.5%. Data were analysed employing SPSS and Mplus to test the hypotheses.
Significant positive relationships were found between decent work, job satisfaction and psychological ownership. Psychological ownership was found to have an indirect influence on the link between decent work and job satisfaction. However, no support was found that psychological ownership plays a moderating role in the relationship.
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DOI: 10.17632/3xsb9nyfhp
title: NigeriaCOVID-19

description: The Coronavirus disease COVID-19 at this point of writing is a pandemic that has rampaged planet earth. It is regarded as a global threat and in some quarters an existential threat. Every possible effort should be made in the application of mathematical models, artificial intelligence, big data, and other resources to stem the spread of this disease. In this dataset, the daily total number of COVID-19 cases in Nigeria from February 27, 2020, to April 5, 2020, were automatically mined every 24 hours from the official websites of NCDC and Wikipedia. The initial data is in raw Excel file format nigeria_covid19.csv. Data with regularly updated case numbers and prediction results from an ensemble of forecasting algorithms can be found in nigeria_covid19_updated.csv. These data are useful as they present facts that drive analytics on COVID-19 cases in Nigeria. It also represents an early reference that can be used in the future. Academic institutions, public health agencies, scientific communities, researchers, students, and self-explorers can use this data to explore, analyze, and develop reliable insights on COVID-19 cases in Nigeria and beyond. The data with regular updates presented can be applied to drive analytics, policy development, and decision making in other countries where data is scarce.
DOI: 10.6084/m9.figshare.7718447.v1
title: Supplementary Material for: Decision-Making Skills Moderate the Relationship between Psychological and Physical Pain with Suicidal Behavior in Depressed Patients

description: Medicine
DOI: 10.17632/6bspjkt7bg
title: Machine learning models and dataset for the prediction of Cr6+ removal of aqueous solutions using the pine cone residue

description: The experimental results of the adsorption of Cr6+ from aqueous solutions using the pine cone residue and the machine learning models used to investigate the experimental parameters are available on this page. Three adsorption conditions are optimized: contact time, pH, and initial solution concentration. The file “Pinha.csv” presents the results of the experiments considering various adsorption conditions. In addition, three machine learning models are employed to predict the behaviour of the experimental results: a multiple linear regression model, a decision tree model, and a random forest model. The machine learning models are in the “Machine learning models.ipynb” file. The maximum Cr6+ removal obtained with the pine cone residue is near 91%, and the machine learning models presented a high correlation coefficient of over 0.9, highlighting the potential of this type of methodology to enhance experimental studies.
DOI: 10.6084/m9.figshare.14191601.v1
title: Supplementary Material for: Rehabilitation under Social Isolation: Outcomes of Older Individuals with Hip Fractures, Admitted to a Postacute Geriatric Rehabilitation Center, during the COVID-19 Pandemic

description: <b><i>Background/Aims:</i></b> The novel coronavirus SARS-CoV-2 is the cause of an ongoing pandemic. The highest mortality rate is observed among the older adult population. During the first wave of the pandemic (March–June 2020), following a national health decree demanding that no visitors or family members be allowed in health institutions, our geriatric rehabilitation center closed gates to all visitors from the outside. We aimed to assess the rehabilitation outcomes of older patients with hip fractures in the first pandemic wave, who underwent rehabilitation under complete social isolation from primary care givers and family members. <b><i>Methods:</i></b> This was a retrospective cohort study. It took place at a university-affiliated, major postacute geriatric rehabilitation center. Rehabilitation outcomes measured were discharge functional independence measure (FIM) score and motor FIM score, FIM score change, motor FIM score change, favorable motor FIM effectiveness, length of stay, discharge destination, and home aid at discharge. <b><i>Results:</i></b> The study group included 36 patients who were admitted during the first wave of the COVID-19 pandemic (March 1, 2020, to June 30, 2020). The control group comprises 106 individuals with hip fractures who were admitted in the respective time periods during the previous 2 years, that is, March 1, 2018, to June 30, 2018, and March 1, 2019, to June 30, 2019. The facility’s occupancy rates were much lower during the first wave of the pandemic in comparison with previous years (78 and 99%, respectively). Patients showed similar demographics and comorbidities, but the social isolation group was more severely deconditioned upon admission. All rehabilitation outcomes were similar between groups. <b><i>Conclusion:</i></b> According to the findings of this retrospective study, social isolation from family and caregivers did not have a detrimental effect on the rehabilitation outcomes of these patients. More evidence must be gathered and presented on the matter.
DOI: 10.6084/m9.figshare.16592681.v1
title: Supplementary Material for: Severe Hypertriglyceridemia Induced by Docetaxel: A Novel Case Report

description: Docetaxel (DOC) is one of the most effective agents for breast cancer treatment. Here, we report docetaxel-induced severe hypertriglyceridemia in a patient previously diagnosed with hyperlipidemia and corresponding therapeutic intervention. A postmenopausal woman, with previously controlled hyperlipidemia using rosuvastatin 5 mg daily, was diagnosed with stage IIB breast cancer with human epidermal growth factor receptor-2 overexpression; she received DOC (75 mg/m<sup>2</sup>), pertuzumab, and trastuzumab treatment as neoadjuvant chemotherapy. The serum triglyceride level was mildly higher than normal, and cholesterol level was normal at baseline. The serum triglyceride level was almost stable after chemotherapy initiation but suddenly increased to grade 3 (770 mg/dL) after the third cycle of the treatment without any symptoms. Sustained-release bezafibrate 400 mg was administered, resulting in a significant decrease to the baseline level; bezafibrate was discontinued on day 28 of the fourth chemotherapy as neoadjuvant chemotherapy was completed. The level was stable around the baseline level during adjuvant chemotherapy with pertuzumab and trastuzumab. Therefore, DOC-induced severe hypertriglyceridemia was strongly indicated in this case. The mechanism underlying the symptoms remains unclear; we speculate that it could be a resultant of a decrease in lipid metabolism as the patient had grade 2 diarrhea. Moreover, her backgrounds, such as mild hypertriglyceridemia, postmenopausal, diabetes, and obesity, in addition to DOC administration might have affected the outcome. Fibrate administration and cessation of treatment were as effective as in previous reports. DOC-induced hypertriglyceridemia presents with the possibility of severe complications. Elucidation of the exact mechanisms and epidemiological features is required for better management.
DOI: 10.6084/m9.figshare.19519375.v1
title: Primary production and dark C fixation.xlsx

description: Dataset provides values for primary production and dark carbon fixation along with the various environmental parameters for the Arabian Sea (the north-western Indian Ocean) sampled during the Indian winter monsoon season.
DOI: 10.6084/m9.figshare.7901426.v1
title: gVCF_HG01812

description: 1000 Genomes gVCF mapped to hs37d5 for HG01812. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.17632/5cwgxpk3pd
title: Near-Infrared Spatiotemporal Color Vision in Humans Enabled by Upconversion Contact Lenses

description: Raw data for the paper "Near-Infrared Spatiotemporal Color Vision in Humans Enabled by Upconversion Contact Lenses"
DOI: 10.17632/9cfkx8wp42
title: Data for: A Genetic Algorithm for the Picture Maze Generation Problem

description: The random raster images and the five recognizable input images used in the experiments are presented.
DOI: 10.17632/yxwc3tbskb
title: Plan Integral Departamental de Drogas

description: El PIIDD es el instrumento de politíca pública, por medio del cual los entes territoriales planifican, formulan, implementan y evalúan, acciones institucionales para la atención de la problemática de drogas desde 3 enfoques : prevención del consumo, atención del consumo problemático de SPA, disrupción del delito.