cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.5281/zenodo.4063887
title: Data set from Ranucci M, Aloisio T, Di Dedda U, Menicanti L, de Vincentiis C, Baryshnikova E; Surgical and Clinical Outcome REsearch (SCORE) group. Gender-based differences in platelet function and platelet reactivity to P2Y12 inhibitors. PLoS One. 2019 Nov 27;14(11):e0225771. doi: 10.1371/journal.pone.0225771. PMID: 31774869; PMCID: PMC6881030.

description: Data set from Ranucci M, Aloisio T, Di Dedda U, Menicanti L, de Vincentiis C, Baryshnikova E; Surgical and Clinical Outcome REsearch (SCORE) group. Gender-based differences in platelet function and platelet reactivity to P2Y12 inhibitors. PLoS One. 2019 Nov 27;14(11):e0225771. doi: 10.1371/journal.pone.0225771. PMID: 31774869; PMCID: PMC6881030. This is the article: <strong>Background: </strong> Gender influences platelet biology. Women have a larger platelet count, but gender-based differences in platelet function remain debated. We performed a study addressing gender-based differences in platelet function using point-of-care platelet function tests (PFT). <strong>Methods: </strong> The patient population consisted of 760 cardiac surgery patients where preoperative PFT (multiple-electrode aggregometry [MEA]) were available. Platelet count and function at the ADPtest and TRAPtest were compared in the overall population and separately in patients with or without residual effects of P2Y12 inhibitors. <strong>Results: </strong> Women had a significantly (P = 0.001) higher platelet count but a non-significantly higher platelet reactivity to ADP. In clopidogrel-treated patients, the platelets ADP reactivity was significantly (P = 0.031) higher in women, and platelet count was the main determinant of platelet hyper-reactivity. Within patients under full clopidogrel effects, women with a platelet count ≥ 200,000 cells/μL had a significantly (P = 0.023) higher rate of high-on-treatment platelet reactivity (HTPR, 45.5%) with respect to males with a platelet count &lt; 200,000 cells/μL (11.9%), with a relative risk of 6.2 (95% confidence interval 1.4-29). <strong>Conclusions: </strong> Our findings confirm that women have a larger platelet count than men, and that this is associated to a trend towards a higher platelet reactivity. HTPR is largely represented in women with a high platelet count. This generates the hypothesis that women requiring P2Y12 inhibitors could potentially benefit from larger doses of drug or should be treated with anti-platelet agents with a low rate of HTPR.
DOI: 10.7488/ba76e727-dc2b-489b-9cbf-78d5b1ec2257
title: Crazy Paving

description: Crazy Paving is a philosophical video journey into human understanding, exploring how we derive and construct meaning from objects, belief systems and the culture that surrounds us. This dataset consists of the video. This dataset is held in the Edinburgh DataVault, directly accessible only to authorised University of Edinburgh users. External users may request access to a copy of the data by contacting the Principal Investigator, Contact Person or Data Manager named on this page. University of Edinburgh users who wish to have direct access should consult the information about retrieving data from the DataVault at: http://www.ed.ac.uk/is/research-support/datavault.
description: Crazy Paving is a philosophical video journey into human understanding, exploring how we derive and construct meaning from objects, belief systems and the culture that surrounds us. ## Access ## This dataset is held in the Edinburgh DataVault, directly accessible only to authorised University of Edinburgh users. External users may request access to a copy of the data by contacting the Principal Investigator, Contact Person or Data Manager named on this page or email CAHSS REF: cahss.ref@ed.ac.uk. University of Edinburgh users who wish to have direct access should consult the information about retrieving data from the DataVault at: http://www.ed.ac.uk/is/research-support/datavault.
DOI: 10.7488/8ba05b63-f5de-4854-8855-3fb41a236596
title: "At the heart of everything a row of holes"

description: "At the heart of everything a row of holes" is an experimental 44-minutes audio-visual installation. The installation is audio-visually tracing the history of automation by focusing of its relationship with labour, entertainment and colonialism. The immersive installation consists of multi-screen video projections, intelligent light display, multi-channel audio and computer controlled Piano. This dataset consists of the film of the work. This dataset is held in the Edinburgh DataVault, directly accessible only to authorised University of Edinburgh users. External users may request access to a copy of the data by contacting the Principal Investigator, Contact Person or Data Manager named on this page. University of Edinburgh users who wish to have direct access should consult the information about retrieving data from the DataVault at: http://www.ed.ac.uk/is/research-support/datavault.
description: "At the heart of everything a row of holes" is an experimental 44-minutes audio-visual installation. The installation is audio-visually tracing the history of automation by focusing of its relationship with labour, entertainment and colonialism. The immersive installation consists of multi-screen video projections, intelligent light display, multi-channel audio and computer controlled Piano. ## Access ## This dataset is held in the Edinburgh DataVault, directly accessible only to authorised University of Edinburgh users. External users may request access to a copy of the data by contacting the Principal Investigator, Contact Person or Data Manager named on this page or email CAHSS REF: cahss.ref@ed.ac.uk. University of Edinburgh users who wish to have direct access should consult the information about retrieving data from the DataVault at: http://www.ed.ac.uk/is/research-support/datavault.
DOI: 10.5281/zenodo.4063909
title: Data set from Ranucci M, Bianchi P, Cotza M, Beccaris C, Silvetti S, Isgrò G, Giamberti A, Baryshnikova E. Fibrinogen levels and postoperative chest drain blood loss in low-weight (&lt;10 kg) children undergoing cardiac surgery. Perfusion. 2019 Nov;34(8):629-636. doi: 10.1177/0267659119854246. Epub 2019 Jun 28. PMID: 31250738.

description: Data set from Ranucci M, Bianchi P, Cotza M, Beccaris C, Silvetti S, Isgrò G, Giamberti A, Baryshnikova E. Fibrinogen levels and postoperative chest drain blood loss in low-weight (&lt;10 kg) children undergoing cardiac surgery. Perfusion. 2019 Nov;34(8):629-636. doi: 10.1177/0267659119854246. Epub 2019 Jun 28. PMID: 31250738. This is the abstract: <strong>Introduction: </strong> Low-weight (&lt;10 kg) children undergoing cardiac surgery with cardiopulmonary bypass are prone to dilution and consumption of soluble coagulation factors and fibrinogen. Low levels of fibrinogen may represent a possible cause of severe postoperative chest drain blood loss. The present study investigates the association between post-cardiopulmonary bypass fibrinogen levels and postoperative chest drain blood loss and severe bleeding, aiming to identify possible cut-off values to trigger specific interventions. <strong>Methods: </strong> Prospective cohort study on 77 patients weighing &lt;10 kg undergoing cardiac surgery with cardiopulmonary bypass. Haemostasis and coagulation data were collected before surgery (standard tests and thromboelastometry), after protamine (thromboelastometry) and at the arrival in the intensive care unit (standard tests). The primary outcome variable was severe bleeding (chest drain blood loss &gt;30 ml kg<sup>-1</sup>/24h). <strong>Results: </strong> Factors being independently associated with severe bleeding were the international normalized ratio and the fibrinogen levels at the arrival in the intensive care unit. Once corrected for other confounders, fibrinogen levels had an odds ratio of 0.2 (95% confidence interval = 0.011-0.54) per 1 gL<sup>-1</sup> for severe bleeding. The discrimination power was fair (area under the curve = 0.770). The best cut-off value was identified at a fibrinogen level of 150 mg dL<sup>-1</sup>, with a sensitivity of 52%, a specificity of 85% and a positive predictive value of 60% for severe bleeding. <strong>Conclusion: </strong> Both a prolonged international normalized ratio and low fibrinogen levels were predictive for severe bleeding, underscoring the role of coagulation factors dilution and consumption in this specific patient population.
DOI: 10.5281/zenodo.4063908
title: Data set from Ranucci M, Bianchi P, Cotza M, Beccaris C, Silvetti S, Isgrò G, Giamberti A, Baryshnikova E. Fibrinogen levels and postoperative chest drain blood loss in low-weight (&lt;10 kg) children undergoing cardiac surgery. Perfusion. 2019 Nov;34(8):629-636. doi: 10.1177/0267659119854246. Epub 2019 Jun 28. PMID: 31250738.

description: Data set from Ranucci M, Bianchi P, Cotza M, Beccaris C, Silvetti S, Isgrò G, Giamberti A, Baryshnikova E. Fibrinogen levels and postoperative chest drain blood loss in low-weight (&lt;10 kg) children undergoing cardiac surgery. Perfusion. 2019 Nov;34(8):629-636. doi: 10.1177/0267659119854246. Epub 2019 Jun 28. PMID: 31250738. This is the abstract: <strong>Introduction: </strong> Low-weight (&lt;10 kg) children undergoing cardiac surgery with cardiopulmonary bypass are prone to dilution and consumption of soluble coagulation factors and fibrinogen. Low levels of fibrinogen may represent a possible cause of severe postoperative chest drain blood loss. The present study investigates the association between post-cardiopulmonary bypass fibrinogen levels and postoperative chest drain blood loss and severe bleeding, aiming to identify possible cut-off values to trigger specific interventions. <strong>Methods: </strong> Prospective cohort study on 77 patients weighing &lt;10 kg undergoing cardiac surgery with cardiopulmonary bypass. Haemostasis and coagulation data were collected before surgery (standard tests and thromboelastometry), after protamine (thromboelastometry) and at the arrival in the intensive care unit (standard tests). The primary outcome variable was severe bleeding (chest drain blood loss &gt;30 ml kg<sup>-1</sup>/24h). <strong>Results: </strong> Factors being independently associated with severe bleeding were the international normalized ratio and the fibrinogen levels at the arrival in the intensive care unit. Once corrected for other confounders, fibrinogen levels had an odds ratio of 0.2 (95% confidence interval = 0.011-0.54) per 1 gL<sup>-1</sup> for severe bleeding. The discrimination power was fair (area under the curve = 0.770). The best cut-off value was identified at a fibrinogen level of 150 mg dL<sup>-1</sup>, with a sensitivity of 52%, a specificity of 85% and a positive predictive value of 60% for severe bleeding. <strong>Conclusion: </strong> Both a prolonged international normalized ratio and low fibrinogen levels were predictive for severe bleeding, underscoring the role of coagulation factors dilution and consumption in this specific patient population.
DOI: 10.18462/iir.iccc.2020.292896
title: Studies on the pressure distribution inside palletised packages during precooling.
DOI: 10.5281/zenodo.4063907
title: Mexiletine Shortens the QT Interval in Patients With Potassium Channel–Mediated Type 2 Long QT Syndrome

description: <strong>BACKGROUND</strong>: Long QT syndrome is a potentially lethal yet highly treatable cardiac channelopathy. Although β-blocker therapy is standard for most patients, concomitant therapy with sodium channel blockers, like mexiletine, is often utilized for patients with sodium channel–mediated type 3 long QT syndrome (LQT3). The potential role of sodium channel blockers in patients with potassium channel–mediated long QT syndrome (ie, LQT1 and LQT2) has not been investigated in detail. <strong>METHODS</strong>: We performed a retrospective chart review on 12 patients (5 females; median age at diagnosis 14.1 years (interquartile range [IQR], 7.7–23; range, 0–59, median heart rate–corrected QT interval [QTc] at diagnosis 557 ms (IQR, 529–605) with genetically established LQT2 (10) or a combination of LQT1/LQT2 (1) or LQT2/LQT3 (1), who received mexiletine. Data were collected on symptomatic status, treatments, and breakthrough cardiac events after diagnosis and initiation of treatment. Additionally, 12-lead ECGs were collected at diagnosis, before initiation of mexiletine and following mexiletine to evaluate the drug’s effect on QTc. <strong>RESULTS</strong>: Before diagnosis, 6 patients were symptomatic and, before initiation of mexiletine, 4 patients experienced ≥1 breakthrough cardiac event on β-blocker. Median age at first mexiletine dose was 24.3 years (IQR, 14–32.4). After mexiletine, the median QTc decreased by 65±45 ms from 547 ms (IQR, 488–558) premexiletine to 470 ms (IQR, 409–529) postmexiletine (P=0.0005) for all patients. In 8 patients (67%), the QTc decreased by ≥ 40 ms with a mean decrease in QTc of 91 ms (P &lt; 0.008).<br> For the 11 patients maintained on mexiletine therapy, there have been no breakthrough cardiac events during follow-up. <strong>CONCLUSIONS</strong>: Although commonly prescribed in patients with LQT3, mexiletine also shortens the QTc significantly in two-thirds of a small subset of patients with potassium channel–mediated LQT2. In patients with LQT2, pharmacological targeting of the physiological late sodium current may provide added therapeutic efficacy to β-blocker therapy.
DOI: 10.5281/zenodo.4063906
title: Mexiletine Shortens the QT Interval in Patients With Potassium Channel–Mediated Type 2 Long QT Syndrome

description: <strong>BACKGROUND</strong>: Long QT syndrome is a potentially lethal yet highly treatable cardiac channelopathy. Although β-blocker therapy is standard for most patients, concomitant therapy with sodium channel blockers, like mexiletine, is often utilized for patients with sodium channel–mediated type 3 long QT syndrome (LQT3). The potential role of sodium channel blockers in patients with potassium channel–mediated long QT syndrome (ie, LQT1 and LQT2) has not been investigated in detail. <strong>METHODS</strong>: We performed a retrospective chart review on 12 patients (5 females; median age at diagnosis 14.1 years (interquartile range [IQR], 7.7–23; range, 0–59, median heart rate–corrected QT interval [QTc] at diagnosis 557 ms (IQR, 529–605) with genetically established LQT2 (10) or a combination of LQT1/LQT2 (1) or LQT2/LQT3 (1), who received mexiletine. Data were collected on symptomatic status, treatments, and breakthrough cardiac events after diagnosis and initiation of treatment. Additionally, 12-lead ECGs were collected at diagnosis, before initiation of mexiletine and following mexiletine to evaluate the drug’s effect on QTc. <strong>RESULTS</strong>: Before diagnosis, 6 patients were symptomatic and, before initiation of mexiletine, 4 patients experienced ≥1 breakthrough cardiac event on β-blocker. Median age at first mexiletine dose was 24.3 years (IQR, 14–32.4). After mexiletine, the median QTc decreased by 65±45 ms from 547 ms (IQR, 488–558) premexiletine to 470 ms (IQR, 409–529) postmexiletine (P=0.0005) for all patients. In 8 patients (67%), the QTc decreased by ≥ 40 ms with a mean decrease in QTc of 91 ms (P &lt; 0.008).<br> For the 11 patients maintained on mexiletine therapy, there have been no breakthrough cardiac events during follow-up. <strong>CONCLUSIONS</strong>: Although commonly prescribed in patients with LQT3, mexiletine also shortens the QTc significantly in two-thirds of a small subset of patients with potassium channel–mediated LQT2. In patients with LQT2, pharmacological targeting of the physiological late sodium current may provide added therapeutic efficacy to β-blocker therapy.
DOI: 10.18462/iir.iccc.2020.292808
title: CO2 transcritical plant with optimized dedicated mechanical subcooling.
DOI: 10.5281/zenodo.4063926
title: DATASET FOR SOMATOSENSORY CORTICAL REPRESENTATION OF THE BODY SIZE

description: DATASET FOR THE PAPER: SOMATOSENSORY CORTICAL REPRESENTATION OF THE BODY SIZE
DOI: 10.5281/zenodo.4063925
title: DATASET FOR SOMATOSENSORY CORTICAL REPRESENTATION OF THE BODY SIZE

description: DATASET FOR THE PAPER: SOMATOSENSORY CORTICAL REPRESENTATION OF THE BODY SIZE
DOI: 10.18462/iir.iccc.2020.292607
title: The thermochemical sorption in the temperature-controlled containers.
DOI: 10.25375/uct.13042169
title: The large communal nests of sociable weavers provide year-round insulated refuge for weavers and pygmy falcons

description: The primary role of nests as structural support for eggs, nestlings, and incubating parents is well established, but our understanding of their secondary roles and their adaptive features is still limited. Nests can serve a particularly important role in protecting or buffering birds from weather. In hot, arid environments, maximum daily temperatures can exceed a species’ upper critical temperature threshold and during the nonbreeding season temperatures may also drop below freezing. Nest structures that help buffer against extreme temperatures may play a crucial role in managing the costs of thermoregulation, especially those nests that are used and maintained year-round. We use extensive year-round data to investigate the thermal benefits of massive colonial structures built by sociable weavers in the arid savannahs of the Kalahari, South Africa. These colonies consist of multiple nesting chambers and are used as roosts when birds are not breeding. We explored whether these structures provide thermal buffering throughout the year and how individual chamber placement within the colony and features of the chambers influenced their thermal buffering capacity. We also investigated whether nest chambers occupied and modified by an obligate nest parasite, the African pygmy falcon provided additional thermal buffering. Our results show that sociable weaver colonies provide thermal benefits throughout the year, buffering both hot and cold ambient extremes. Chambers with longer entrance tunnels provided better insulation than chambers with shorter entrance tunnels, and chambers located toward the center of a colony provided greater insulation than chambers at the edge. Chambers occupied by falcons did not display additional thermal benefits, which may be due to falcons choosing chambers with shorter entrance tunnels. Because falcons are larger than weavers, they may find it harder to enter chambers with longer entrance tunnels, and/or because weavers cease maintenance of those chambers. In conclusion, the communal nests of sociable weaver provide thermal benefits to weavers and heterospecifics alike, creating a more optimal environment for breeding, roosting and reducing thermal stress. In a landscape that is becoming increasingly harsh under climate change, the importance of these structures to the local animal communities may also increase.<br>(Paper provisionally accepted to <i>Frontiers in Ecology and Evolution</i>. DOI to follow.)
DOI: 10.25375/uct.13042169.v1
title: The large communal nests of sociable weavers provide year-round insulated refuge for weavers and pygmy falcons

description: The primary role of nests as structural support for eggs, nestlings, and incubating parents is well established, but our understanding of their secondary roles and their adaptive features is still limited. Nests can serve a particularly important role in protecting or buffering birds from weather. In hot, arid environments, maximum daily temperatures can exceed a species’ upper critical temperature threshold and during the nonbreeding season temperatures may also drop below freezing. Nest structures that help buffer against extreme temperatures may play a crucial role in managing the costs of thermoregulation, especially those nests that are used and maintained year-round. We use extensive year-round data to investigate the thermal benefits of massive colonial structures built by sociable weavers in the arid savannahs of the Kalahari, South Africa. These colonies consist of multiple nesting chambers and are used as roosts when birds are not breeding. We explored whether these structures provide thermal buffering throughout the year and how individual chamber placement within the colony and features of the chambers influenced their thermal buffering capacity. We also investigated whether nest chambers occupied and modified by an obligate nest parasite, the African pygmy falcon provided additional thermal buffering. Our results show that sociable weaver colonies provide thermal benefits throughout the year, buffering both hot and cold ambient extremes. Chambers with longer entrance tunnels provided better insulation than chambers with shorter entrance tunnels, and chambers located toward the center of a colony provided greater insulation than chambers at the edge. Chambers occupied by falcons did not display additional thermal benefits, which may be due to falcons choosing chambers with shorter entrance tunnels. Because falcons are larger than weavers, they may find it harder to enter chambers with longer entrance tunnels, and/or because weavers cease maintenance of those chambers. In conclusion, the communal nests of sociable weaver provide thermal benefits to weavers and heterospecifics alike, creating a more optimal environment for breeding, roosting and reducing thermal stress. In a landscape that is becoming increasingly harsh under climate change, the importance of these structures to the local animal communities may also increase.<br>(Paper provisionally accepted to <i>Frontiers in Ecology and Evolution</i>. DOI to follow.)
DOI: 10.5281/zenodo.4063932
title: From patient-specific induced pluripotent stem cells to clinical translation in long QT syndrome Type 2

description: <strong>Aims</strong>: Having shown that Lumacaftor rescued the hERG trafficking defect in the induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) of two LQT2 patients, we tested whether the commercial association Lumacaftor+Ivacaftor (LUM+IVA) could shorten the QTc in the same two patients. <strong>Methods and Results</strong>: After hospital admission and one day of baseline recordings, half dose LUM+IVA was administered on day 1, followed by full dose (LUM 800 mg + IVA 500 mg) for 7 days. A continuous 12-lead Holter ECG allowed a large number of blind QTc measurements. LUM+IVA shortened QTc significantly in both patients: in V6 from 551±22 to 523±35 ms in Patient1, and from 472±21 to 449±20 ms in Patient2; in DII from 562±25 to 549±35 ms in Patient1, and from 485±32 to 452±18 ms in Patient2. In both patients the percentage of QTc values in the lower tertile increased strikingly: in V6 from 33% to 68% and from 33% to 76%; in DII from 33% to 50% and from 33% to 87%. In the wash-out period a rebound in QTc was observed. Patient1 more than Patient2 developed diarrhoea during the study. <strong>Conclusion</strong>: This represents the first attempt to validate in patients the <em>in vitro</em> results of a drug repurposing strategy for cardiovascular disorders. LUM+IVA shortened significantly the QTc in the two LQT2 patients with a trafficking defect, largely confirming the findings in their iPSC-CMs but with smaller quantitative changes. The findings are encouraging but immediate translation into clinical practice, without validation in more patients, would be premature.