cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.16799996
title: Impact of hepatocyte-specific deletion of staphylococcal nuclease and tudor domain containing 1 (SND1) on liver insulin resistance and acute liver failure of mice

description: Although our previous research shows an ameliorated high-fat diet (HFD)-induced hepatic steatosis and insulin resistance in global <i>SND1</i> transgenic mice, the involvement of SND1 loss-of-function in hepatic metabolism remains elusive. Herein, we aim to explore the potential impact of hepatocyte-specific <i>SND1</i> deletion on insulin-resistant mice. As SND1 is reported to be linked to inflammatory response, the pathobiological feature of acute liver failure (ALF) is also investigated. Hence, we construct the conditional liver knockout (LKO) mice of <i>SND1</i> for the first time. Under the condition of HFD, the absence of hepatic <i>SND1</i> affects the weight of white adipose tissue, but not the gross morphology, body weight, cholesterol level, liver weight, and hepatic steatosis of mice. Furthermore, we fail to observe significant differences in either HFD-induced insulin resistance or lipopolysaccharide/D-galactosamine-induced (LPS/D-GaIN) ALF between LKO and wild type (WT) mice in terms of inflammation and tissue damage. Compared with negative controls, there is no differential <i>SND1</i> expression in various species of sample with insulin resistance or ALF, based on several gene expression omnibus datasets, including GSE23343, GSE160646, GSE120243, GSE48794, GSE13271, GSE151268, GSE62026, GSE120652, and GSE38941. Enrichment result of SND1-binding partners or related genes indicates a sequence of issues related to RNA or lipid metabolism, but not glucose homeostasis or hepatic failure. Overall, hepatic SND1 is insufficient to alter the phenotypes of hepatic insulin resistance and acute liver failure in mice. The SND1 in various organs is likely to cooperate in regulating glucose homeostasis by affecting the expression of lipid metabolism-related RNA transcripts during stress.
DOI: 10.6084/m9.figshare.25151123
title: Raw data of TFLS 2024 0206.zip

description: Data belonging to the research on <b>Long non-coding RNA LINC01224 plays an oncogenic role in endometrial cancer</b> <b>through Bcl2/Bax and Wnt/β-catenin signaling pathways</b>
DOI: 10.6084/m9.figshare.25151123.v1
title: Raw data of TFLS 2024 0206.zip

description: Data belonging to the research on <b>Long non-coding RNA LINC01224 plays an oncogenic role in endometrial cancer</b> <b>through Bcl2/Bax and Wnt/β-catenin signaling pathways</b>
DOI: 10.6084/m9.figshare.16799996.v2
title: Impact of hepatocyte-specific deletion of staphylococcal nuclease and tudor domain containing 1 (SND1) on liver insulin resistance and acute liver failure of mice

description: Although our previous research shows an ameliorated high-fat diet (HFD)-induced hepatic steatosis and insulin resistance in global <i>SND1</i> transgenic mice, the involvement of SND1 loss-of-function in hepatic metabolism remains elusive. Herein, we aim to explore the potential impact of hepatocyte-specific <i>SND1</i> deletion on insulin-resistant mice. As SND1 is reported to be linked to inflammatory response, the pathobiological feature of acute liver failure (ALF) is also investigated. Hence, we construct the conditional liver knockout (LKO) mice of <i>SND1</i> for the first time. Under the condition of HFD, the absence of hepatic <i>SND1</i> affects the weight of white adipose tissue, but not the gross morphology, body weight, cholesterol level, liver weight, and hepatic steatosis of mice. Furthermore, we fail to observe significant differences in either HFD-induced insulin resistance or lipopolysaccharide/D-galactosamine-induced (LPS/D-GaIN) ALF between LKO and wild type (WT) mice in terms of inflammation and tissue damage. Compared with negative controls, there is no differential <i>SND1</i> expression in various species of sample with insulin resistance or ALF, based on several gene expression omnibus datasets, including GSE23343, GSE160646, GSE120243, GSE48794, GSE13271, GSE151268, GSE62026, GSE120652, and GSE38941. Enrichment result of SND1-binding partners or related genes indicates a sequence of issues related to RNA or lipid metabolism, but not glucose homeostasis or hepatic failure. Overall, hepatic SND1 is insufficient to alter the phenotypes of hepatic insulin resistance and acute liver failure in mice. The SND1 in various organs is likely to cooperate in regulating glucose homeostasis by affecting the expression of lipid metabolism-related RNA transcripts during stress.
DOI: 10.6084/m9.figshare.16799996.v1
title: Impact of hepatocyte-specific deletion of staphylococcal nuclease and tudor domain containing 1 (SND1) on liver insulin resistance and acute liver failure of mice

description: Although our previous research shows an ameliorated high-fat diet (HFD)-induced hepatic steatosis and insulin resistance in global <i>SND1</i> transgenic mice, the involvement of SND1 loss-of-function in hepatic metabolism remains elusive. Herein, we aim to explore the potential impact of hepatocyte-specific <i>SND1</i> deletion on insulin-resistant mice. As SND1 is reported to be linked to inflammatory response, the pathobiological feature of acute liver failure (ALF) is also investigated. Hence, we construct the conditional liver knockout (LKO) mice of <i>SND1</i> for the first time. Under the condition of HFD, the absence of hepatic <i>SND1</i> affects the weight of white adipose tissue, but not the gross morphology, body weight, cholesterol level, liver weight, and hepatic steatosis of mice. Furthermore, we fail to observe significant differences in either HFD-induced insulin resistance or lipopolysaccharide/D-galactosamine-induced (LPS/D-GaIN) ALF between LKO and wild type (WT) mice in terms of inflammation and tissue damage. Compared with negative controls, there is no differential <i>SND1</i> expression in various species of sample with insulin resistance or ALF, based on several gene expression omnibus datasets, including GSE23343, GSE160646, GSE120243, GSE48794, GSE13271, GSE151268, GSE62026, GSE120652, and GSE38941. Enrichment result of SND1-binding partners or related genes indicates a sequence of issues related to RNA or lipid metabolism, but not glucose homeostasis or hepatic failure. Overall, hepatic SND1 is insufficient to alter the phenotypes of hepatic insulin resistance and acute liver failure in mice. The SND1 in various organs is likely to cooperate in regulating glucose homeostasis by affecting the expression of lipid metabolism-related RNA transcripts during stress.
DOI: 10.6084/m9.figshare.7362824
title: Additional file 3: of Genomic analyses based on pulmonary adenocarcinoma in situ reveal early lung cancer signature

description: Table S2. The functional annotations of the 107 AIS-specific genes. (XLSX 12 kb)
DOI: 10.6084/m9.figshare.7362824.v1
title: Additional file 3: of Genomic analyses based on pulmonary adenocarcinoma in situ reveal early lung cancer signature

description: Table S2. The functional annotations of the 107 AIS-specific genes. (XLSX 12 kb)
DOI: 10.6084/m9.figshare.25151159
title: Participation Consent for Publication

description: This form was utilized for providing written agreement from participant in regards to publication.
DOI: 10.6084/m9.figshare.11557149
title: MOESM2 of Fossils from South China redefine the ancestral euarthropod body plan

description: Additional file 2. mrb file including morphological matrix and parameters used for the phylogenetic analysis.
DOI: 10.6084/m9.figshare.11557149.v1
title: MOESM2 of Fossils from South China redefine the ancestral euarthropod body plan

description: Additional file 2. mrb file including morphological matrix and parameters used for the phylogenetic analysis.
DOI: 10.6084/m9.figshare.11557158
title: MOESM2 of Climate factors driven typhus group rickettsiosis incidence dynamics in Xishuangbanna Dai autonomous prefecture of Yunnan province in China, 2005–2017

description: Additional file 2: Table S1. Correlation analysis of TGR cases and meteorological factors using Spearman’s correlation test
DOI: 10.6084/m9.figshare.11557158.v1
title: MOESM2 of Climate factors driven typhus group rickettsiosis incidence dynamics in Xishuangbanna Dai autonomous prefecture of Yunnan province in China, 2005–2017

description: Additional file 2: Table S1. Correlation analysis of TGR cases and meteorological factors using Spearman’s correlation test
DOI: 10.6084/m9.figshare.7362854
title: Additional file 5: of Genomic analyses based on pulmonary adenocarcinoma in situ reveal early lung cancer signature

description: Table S3. List of the 20 early lung cancer signature genes and their cancer related functions. (XLSX 11 kb)
DOI: 10.6084/m9.figshare.7362854.v1
title: Additional file 5: of Genomic analyses based on pulmonary adenocarcinoma in situ reveal early lung cancer signature

description: Table S3. List of the 20 early lung cancer signature genes and their cancer related functions. (XLSX 11 kb)
DOI: 10.6084/m9.figshare.11557170
title: MOESM3 of Climate factors driven typhus group rickettsiosis incidence dynamics in Xishuangbanna Dai autonomous prefecture of Yunnan province in China, 2005â€“2017

description: Additional file 3. The relative risks of different factors at different lag weeks
DOI: 10.6084/m9.figshare.11557170.v1
title: MOESM3 of Climate factors driven typhus group rickettsiosis incidence dynamics in Xishuangbanna Dai autonomous prefecture of Yunnan province in China, 2005â€“2017

description: Additional file 3. The relative risks of different factors at different lag weeks
DOI: 10.6084/m9.figshare.14178630
title: Differences in east-west thermo-rheological structure and lithospheric deformation in the Qaidam Basin, Northern Tibetan Plateau, China

description: To investigate the differences in east-west lithospheric deformation in the Qaidam Basin, we present thermo-rheological models of two profiles across the western Qaidam Basin (WQB) and eastern Qaidam Basin (EQB). The differences in east-west geodynamic deformation styles are also described, involving GPS motions, focal mechanisms (P axes), seismic anisotropy (SKS-wave splitting), and low-velocity zones (LVZs). The WQB is characterized by a warm destabilized cratonic basin with a weak lower crust, and the rheological structure changes from a rather weak crème brûlée-1 regime into a strong jelly sandwich-1 regime, from the Altyn-Qaidam boundary to the northeastern corner of the WQB. Combined with the limited distribution of the LVZs and the strong crust-mantle decoupling revealed by the unmatched pattern between P axes (N20ºE) and SKS-wave splitting (N110°E), the crust-mantle mixing related to the under-thrusting of the Tarim Basin along the Altyn Tagh Fault is suggested as the primary tectonic dynamic inducement of the destabilized WQB craton, which weakens the lithospheric strength greatly and contributes to the shallow brittle deformation. However, the EQB performs as a typical cold and rigid cratonic basin characterized by a jelly sandwich-2 rheological regime, which is sufficiently strong to maintain crust-mantle coupling. The LVZs beneath the EQB revealed by recent wide-angle seismic profiles have only a small effect on the lithospheric strength drop. The EQB could be regarded as a solid basin, anchored in the NE Tibetan Plateau, which shows a strong resistance to NE extrusion of the weak plateau material, leading to clockwise rotation.
DOI: 10.6084/m9.figshare.14178630.v1
title: Differences in east-west thermo-rheological structure and lithospheric deformation in the Qaidam Basin, Northern Tibetan Plateau, China

description: To investigate the differences in east-west lithospheric deformation in the Qaidam Basin, we present thermo-rheological models of two profiles across the western Qaidam Basin (WQB) and eastern Qaidam Basin (EQB). The differences in east-west geodynamic deformation styles are also described, involving GPS motions, focal mechanisms (P axes), seismic anisotropy (SKS-wave splitting), and low-velocity zones (LVZs). The WQB is characterized by a warm destabilized cratonic basin with a weak lower crust, and the rheological structure changes from a rather weak crème brûlée-1 regime into a strong jelly sandwich-1 regime, from the Altyn-Qaidam boundary to the northeastern corner of the WQB. Combined with the limited distribution of the LVZs and the strong crust-mantle decoupling revealed by the unmatched pattern between P axes (N20ºE) and SKS-wave splitting (N110°E), the crust-mantle mixing related to the under-thrusting of the Tarim Basin along the Altyn Tagh Fault is suggested as the primary tectonic dynamic inducement of the destabilized WQB craton, which weakens the lithospheric strength greatly and contributes to the shallow brittle deformation. However, the EQB performs as a typical cold and rigid cratonic basin characterized by a jelly sandwich-2 rheological regime, which is sufficiently strong to maintain crust-mantle coupling. The LVZs beneath the EQB revealed by recent wide-angle seismic profiles have only a small effect on the lithospheric strength drop. The EQB could be regarded as a solid basin, anchored in the NE Tibetan Plateau, which shows a strong resistance to NE extrusion of the weak plateau material, leading to clockwise rotation.
DOI: 10.6084/m9.figshare.11557227
title: MOESM1 of Genome-wide comparative analysis of the BAHD superfamily in seven Rosaceae species and expression analysis in pear (Pyrus bretschneideri)

description: Additional file 1: Table S1. Gene lists and basic feature of all identified BAHD genes. Table S2. Motif sequences identified by MEME tools in pear BAHDs. Table S3. Information of gene duplication events identified in all identified BAHD genes. Table S4. Collinearity relationship among BAHD genes in the same species. Table S5. Ka, Ks and Ka/Ks value of duplicated gene pairs among BAHD. Table S6. The TPM value of BAHD genes in pear. Table S7. Content of total ester at different developmental stages of Chinese white pear. Table S8. The list of molecules identified as esters. Table S9. Primers for qRT-PCR of candidate genes in Chinese white pear BAHD gene family.
DOI: 10.6084/m9.figshare.11557227.v1
title: MOESM1 of Genome-wide comparative analysis of the BAHD superfamily in seven Rosaceae species and expression analysis in pear (Pyrus bretschneideri)

description: Additional file 1: Table S1. Gene lists and basic feature of all identified BAHD genes. Table S2. Motif sequences identified by MEME tools in pear BAHDs. Table S3. Information of gene duplication events identified in all identified BAHD genes. Table S4. Collinearity relationship among BAHD genes in the same species. Table S5. Ka, Ks and Ka/Ks value of duplicated gene pairs among BAHD. Table S6. The TPM value of BAHD genes in pear. Table S7. Content of total ester at different developmental stages of Chinese white pear. Table S8. The list of molecules identified as esters. Table S9. Primers for qRT-PCR of candidate genes in Chinese white pear BAHD gene family.
DOI: 10.6084/m9.figshare.11557272
title: MOESM1 of Metabolomic analyses reveal substances that contribute to the increased freezing tolerance of alfalfa (Medicago sativa L.) after continuous water deficit

description: Additional file 1. Detailed information for all the differential metabolites detected in the seven comparisons.
DOI: 10.6084/m9.figshare.11557272.v1
title: MOESM1 of Metabolomic analyses reveal substances that contribute to the increased freezing tolerance of alfalfa (Medicago sativa L.) after continuous water deficit

description: Additional file 1. Detailed information for all the differential metabolites detected in the seven comparisons.
DOI: 10.6084/m9.figshare.11557278
title: MOESM2 of Metabolomic analyses reveal substances that contribute to the increased freezing tolerance of alfalfa (Medicago sativa L.) after continuous water deficit

description: Additional file 2. Fold changes in differential metabolites upregulated in seven comparison groups.
DOI: 10.6084/m9.figshare.11557278.v1
title: MOESM2 of Metabolomic analyses reveal substances that contribute to the increased freezing tolerance of alfalfa (Medicago sativa L.) after continuous water deficit

description: Additional file 2. Fold changes in differential metabolites upregulated in seven comparison groups.
DOI: 10.6084/m9.figshare.25151399.v1
title: Supplementary Material for: Isolated non-secretory extramedullary relapse of multiple myeloma responded completely to localized radiotherapy

description: INTRODUCTION: Non-secretory multiple myeloma (NSMM) is a rare form of multiple myeloma (MM) that is often difficult to detect and has not yet been well characterised. This is due to the lack of production or the presence of monoclonal proteins levels below levels detectable by testing such as serum/urine electrophoresis (SPEP/UPEP) and immunofixation. 
CASE PRESENTATION: Two patients of ours were being treated for MM with typical courses of systemic therapy. By the 3rd line therapy, both developed an extramedullary mass, one in the pelvis and the other in the neck. In both cases blood work showed no measurable monoclonal protein (MP), normal free light chain levels and unremarkable skeletal surveys. Secondary malignancies were suspected due to the clinical presentation in each case, and biopsies confirmed the presence of non-secretory plasmacytomas. Both patients were only treated with localized radiotherapy with a total dose of 2000 cGy in 5 fractions over 1 week. Ultimately, this resolved the original masses with no residual tumours. No changes had to be made to their systemic therapies, and both patients remain stable in remission.
CONCLUSION: Non-secretory multiple myeloma relapse is not unusual and should be suspected in patients with relapsed refractory disease. Relapse should be confirmed by a tissue biopsy, and secondary malignancies should be ruled out. Radiotherapy is an excellent option to treat localized relapse and preserve the current line of systemic anti-myeloma therapy.
DOI: 10.6084/m9.figshare.11557287
title: MOESM3 of Metabolomic analyses reveal substances that contribute to the increased freezing tolerance of alfalfa (Medicago sativa L.) after continuous water deficit

description: Additional file 3. Proportions of differential metabolites in each class/subclass level out of all the differential metabolites in each comparison.
DOI: 10.6084/m9.figshare.11557287.v1
title: MOESM3 of Metabolomic analyses reveal substances that contribute to the increased freezing tolerance of alfalfa (Medicago sativa L.) after continuous water deficit

description: Additional file 3. Proportions of differential metabolites in each class/subclass level out of all the differential metabolites in each comparison.
DOI: 10.6084/m9.figshare.25151399
title: Supplementary Material for: Isolated non-secretory extramedullary relapse of multiple myeloma responded completely to localized radiotherapy

description: INTRODUCTION: Non-secretory multiple myeloma (NSMM) is a rare form of multiple myeloma (MM) that is often difficult to detect and has not yet been well characterised. This is due to the lack of production or the presence of monoclonal proteins levels below levels detectable by testing such as serum/urine electrophoresis (SPEP/UPEP) and immunofixation. 
CASE PRESENTATION: Two patients of ours were being treated for MM with typical courses of systemic therapy. By the 3rd line therapy, both developed an extramedullary mass, one in the pelvis and the other in the neck. In both cases blood work showed no measurable monoclonal protein (MP), normal free light chain levels and unremarkable skeletal surveys. Secondary malignancies were suspected due to the clinical presentation in each case, and biopsies confirmed the presence of non-secretory plasmacytomas. Both patients were only treated with localized radiotherapy with a total dose of 2000 cGy in 5 fractions over 1 week. Ultimately, this resolved the original masses with no residual tumours. No changes had to be made to their systemic therapies, and both patients remain stable in remission.
CONCLUSION: Non-secretory multiple myeloma relapse is not unusual and should be suspected in patients with relapsed refractory disease. Relapse should be confirmed by a tissue biopsy, and secondary malignancies should be ruled out. Radiotherapy is an excellent option to treat localized relapse and preserve the current line of systemic anti-myeloma therapy.
DOI: 10.6084/m9.figshare.16800172
title: Additional file 2 of Meta-analysis of the role of zinc in coordinating absorption of mineral elements in wheat seedlings

description: Additional file 2: Table S1. Fitting function of Pearson correlation analysis between elements. Table S2. Variance analysis of absorption values of various elements for different group cultivar.
DOI: 10.6084/m9.figshare.16800172.v1
title: Additional file 2 of Meta-analysis of the role of zinc in coordinating absorption of mineral elements in wheat seedlings

description: Additional file 2: Table S1. Fitting function of Pearson correlation analysis between elements. Table S2. Variance analysis of absorption values of various elements for different group cultivar.
DOI: 10.6084/m9.figshare.11557293
title: MOESM4 of Metabolomic analyses reveal substances that contribute to the increased freezing tolerance of alfalfa (Medicago sativa L.) after continuous water deficit

description: Additional file 4. All the pathways identified in the KEGG enrichment analysis.
DOI: 10.6084/m9.figshare.11557293.v1
title: MOESM4 of Metabolomic analyses reveal substances that contribute to the increased freezing tolerance of alfalfa (Medicago sativa L.) after continuous water deficit

description: Additional file 4. All the pathways identified in the KEGG enrichment analysis.
DOI: 10.6084/m9.figshare.16800178
title: Additional file 1 of Breed-specific reference sequence optimized mapping accuracy of NGS analyses for pigs

description: Additional file 1: Table S1. Sample information on whole-genome sequencing data.
DOI: 10.6084/m9.figshare.16800178.v1
title: Additional file 1 of Breed-specific reference sequence optimized mapping accuracy of NGS analyses for pigs

description: Additional file 1: Table S1. Sample information on whole-genome sequencing data.
DOI: 10.6084/m9.figshare.16800181
title: Additional file 2 of Breed-specific reference sequence optimized mapping accuracy of NGS analyses for pigs

description: Additional file 2: Table S2. Statistics of mapping ratio, coverage and CPU time cost for mitogenome mapping of NGS data.
DOI: 10.6084/m9.figshare.16800181.v1
title: Additional file 2 of Breed-specific reference sequence optimized mapping accuracy of NGS analyses for pigs

description: Additional file 2: Table S2. Statistics of mapping ratio, coverage and CPU time cost for mitogenome mapping of NGS data.
DOI: 10.6084/m9.figshare.16800184
title: Additional file 3 of Breed-specific reference sequence optimized mapping accuracy of NGS analyses for pigs

description: Additional file 3: Table S3. SNP information resulting from Sanger sequences aligning to the breed-specific references.
DOI: 10.6084/m9.figshare.16800184.v1
title: Additional file 3 of Breed-specific reference sequence optimized mapping accuracy of NGS analyses for pigs

description: Additional file 3: Table S3. SNP information resulting from Sanger sequences aligning to the breed-specific references.
DOI: 10.6084/m9.figshare.11557299
title: MOESM5 of Metabolomic analyses reveal substances that contribute to the increased freezing tolerance of alfalfa (Medicago sativa L.) after continuous water deficit

description: Additional file 5. The raw data for dry weight, moisture content of roots, LT50, malondialdehyde, starch, total soluble sugar, total soluble protein, total amino acid and proline in the two treatments at the ends of the four phases.