cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.5061/dryad.2fqz612m4
title: Sequencing data from: High levels of primary biogenic organic aerosols are driven by only a few plant-associated microbial taxa

description: Primary biogenic organic aerosols (PBOA) represent a major fraction of
 coarse organic matter (OM) in air. Despite their implication in many
 atmospheric processes and human health problems, we surprisingly know
 little about PBOA characteristics (i.e., composition, dominant sources,
 and contribution to airborne-particles). In addition, specific primary
 sugar compounds (SCs) are generally used as markers of PBOA associated
 with bacteria and fungi but our knowledge of microbial communities
 associated with atmospheric particulate matter (PM) remains incomplete.
 This work aimed at providing a comprehensive understanding of the
 microbial fingerprints associated with SCs in PM10 (particles smaller than
 10µm) and their main sources in the surrounding environment (soils and
 vegetation). An intensive study was conducted on PM10 collected at rural
 background site located in an agricultural area in France. We combined
 high-throughput sequencing of bacteria and fungi with detailed
 physicochemical characterization of PM10, soils and plant samples, and
 monitored meteorology and agricultural activities throughout the sampling
 period. Results shows that in summer SCs in PM10 are a major contributor
 of OM in air, representing 0.8 to 13.5% of OM mass. SCs concentrations are
 clearly determined by the abundance of only a few specific airborne fungi
 and bacteria taxa. The temporal fluctuations in the abundance of only 4
 predominant fungal genera, namely Cladosporium, Alternaria, Sporobolomyces
 and Dioszegia reflect the temporal dynamics in SC concentrations. Among
 bacteria taxa, the abundance of only Massilia, Pseudomonas,
 Frigoribacterium and Sphingomonas are positively correlated with SC
 species. These microbial are significantly enhanced in leaf over soil
 samples. Interestingly, the overall community structure of bacteria and
 fungi are similar within PM10 and leaf samples and significantly distinct
 between PM10 and soil samples, indicating that surrounding vegetation are
 the major source of SC-associated microbial taxa in PM10 on rural area of
 France.
description: Sample types:  Bacterial and fungal
 community compositions were surveyed using respectively the Bact02 and
 Fung02 primer pairs. This files contain different type of samples : letter
 'A' corresponds to aerosol samples, while 'F' and
 'S' correspond respectively to leaf and soil samples.
description: Database of MOTUs and sequences
 The databases contain the number of reads of the different MOTUs
 in the samples studied, together with information on taxonomic
 assignment.
DOI: 10.5061/dryad.280gb5mn1
title: Data from: Association of years to parent’s sporadic onset and risk factors with neural integrity and Alzheimer’s biomarkers

description: Objective: To evaluate the hypothesis that proximity to parental age at
 onset (AAO) in sporadic Alzheimer’s disease (AD) is associated with
 greater AD and neural injury biomarker alterations during midlife and to
 assess the role of non-modifiable and modifiable factors. Methods: This
 observational study included 290 cognitively unimpaired (CU) participants
 with family history (FH) of clinically-diagnosed sporadic AD (aged 49-73)
 from the ALFA study. [18F]Flutemetamol-PET SUVRs, CSF Aβ42/40 ratio and
 p-tau were used as AD biomarkers. Hippocampal volumes and CSF t-tau were
 used as neural injury biomarkers. Mental and vascular health proxies were
 calculated. In multiple regression models, we assessed the effect of
 proximity to parental AAO and its interaction with age on AD and neural
 injury biomarkers. Then, we evaluated the effects of FH load (number of
 parents affected), sex, APOE-Ɛ4, education, vascular and mental health.
 Results: Proximity to parental AAO was associated with β-amyloid, but not
 with neural injury biomarkers, and interacted with sex and age, showing
 women and older participants increased β-amyloid. FH load and APOE-Ɛ4
 showed independent contributions to β-amyloid load. Education, vascular
 and mental health proxies were not associated with AD biomarkers. However,
 lower mental health proxies were associated with decreased hippocampal
 volumes with age. Conclusions: The identification of the earliest
 biomarker changes and modifiable factors to be targeted in early
 interventions is crucial for AD prevention. Proximity to parental AAO may
 offer a timeline for detection of incipient β-amyloid changes in women. In
 risk-enriched middle-aged cohorts, mental health may be a target for early
 interventions. Classification of evidence: This study provides Class II
 evidence that in CU adults with FH of sporadic AD proximity to parental
 AAO was associated with β-amyloid but not with neural injury biomarkers.
DOI: 10.25338/b8t032
title: Apis mellifera wing images (Africanized honey bees)

description: Honey bee wing lengths and vein patterns differ between major genetic
 lineages. In this dataset we publish forewing images for 276 individual
 honey bees with mixtures of African and European genetic
 ancestry of varying proportions. In the
 associated population genomics study, we
 compared evolutionary outcomes of the Africanized honey bee
 invasion in North and South America (California and
 Argentina). Samples from Argentina were provided by the National
 Institute of Agricultural Technology (INTA), Argentina.
description: Fore wings for 276 individual honey bees, imaged from
 slides. Freely-foraging honey bees were collected in 2018 from transects
 across the present African-to-European ancestry transition (hybrid) zones
 in California and Argentina. These wing images can be paired with
 individual whole-genome sequences, estimated ancestry proportions, GPS
 locations and wing length measurements from imageJ (see associated
 publication).  
description: Wings from 2 samples sequenced in the associated population
 genetics study were not imaged due to excessive damage. Images included
 here may additionally show some wing tatter or damage (e.g. n = 7 images
 had to be excluded from original study of wing lengths).
DOI: 10.5061/dryad.kwh70rz17
title: Whole exome sequencing reveals a long-term decline in effective population size of red spruce (Picea rubens)

description: Understanding the factors influencing the current distribution of genetic
 diversity across a species range is one of the main questions of
 evolutionary biology, especially given the increasing threat to
 biodiversity posed by climate change. Historical demographic processes
 such as population expansion or bottlenecks and decline are known to exert
 a predominant influence on past and current levels of genetic diversity,
 and revealing this demo-genetic history can have immediate conservation
 implications. We used a whole-exome capture sequencing approach to analyze
 polymorphism across the gene space of red spruce (Picea
 rubens Sarg.), an endemic and emblematic tree species of eastern
 North America high elevation forests that are facing the combined threat
 of global warming and increasing human activities. We sampled a total of
 340 individuals, including populations from the current core of the range
 in northeastern USA and southeastern Canada and from the southern portions
 of its range along the Appalachian Mountains, where populations occur as
 highly fragmented mountaintop “sky islands”. Exome capture baits were
 designed from the closely relative white spruce (P. glauca Voss)
 transcriptome, and sequencing successfully captured most regions on or
 near our target genes, resulting in the generation of a new and expansive
 genomic resource for studying standing genetic variation in red spruce
 applicable to its conservation. Our results, based on over 2 million
 exome-derived variants, indicate that red spruce is structured into three
 distinct ancestry groups that occupy different geographic regions of its
 highly fragmented range.  Moreover, these groups show
 small Ne, with a temporal history of sustained population decline
 that has been ongoing for thousands (or even hundreds of thousands) of
 years. These results demonstrate the broad potential of genomic studies
 for revealing details of the demographic history that can inform
 management and conservation efforts of non-model species with active
 restoration programs, such as red spruce.
description: The "Info_samples.txt" file gives information about the
 population, region and site coordinates for all the sampled
 individuals. The
 "Red_Spruce_intersect_poly_snpeff.vcf.gz" file is a vcf file
 including the genotype likelihoods and annotations of all the polymorphic
 sites used in the study.
DOI: 10.15468/dl.bh4ah6
title: Occurrence Download

description: A dataset containing 1967319 species occurrences available in GBIF matching the query:
{
 "and" : [
 "BasisOfRecord is one of (Observation, Human Observation, Specimen)",
 "Geometry POLYGON((-74.18 43.34,-54.59 43.34,-54.59 48.25,-74.18 48.25,-74.18 43.34))",
 "HasCoordinate is true",
 "License is one of (CC-BY-NC 4.0, CC-BY 4.0, CC0 1.0)",
 "OccurrenceStatus is Present",
 "TaxonKey is Plantae"
 ]
}

 The dataset includes 1967319 records from 437 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0002260-260126135527185/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.mqrynd
title: Occurrence Download

description: A dataset containing 2205 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Bombus suckleyi Greene, 1860"
 ]
}

 The dataset includes 2205 records from 41 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0007279-250525065834625/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.13130/rd_unimi/pddrps/mvp7wg
title: Maggio_1937_Pagina_296.jpg

description: Bulletin of 1937/05/30
DOI: 10.13130/rd_unimi/pddrps/ibtubh
title: Maggio_1937_Pagina_297.jpg

description: Bulletin of 1937/05/30
DOI: 10.13130/rd_unimi/pddrps/vtwryy
title: Maggio_1937_Pagina_298.jpg

description: Bulletin of 1937/05/30
DOI: 10.13130/rd_unimi/pddrps/yzpdby
title: Maggio_1937_Pagina_299.jpg

description: Bulletin of 1937/05/30
DOI: 10.13130/rd_unimi/pddrps/mssmsb
title: Maggio_1937_Pagina_300.jpg

description: Bulletin of 1937/05/30
DOI: 10.13130/rd_unimi/pddrps/wsb0g4
title: Maggio_1937_Pagina_301.jpg

description: Bulletin of 1937/05/31
DOI: 10.13130/rd_unimi/pddrps/oflgdd
title: Maggio_1937_Pagina_302.jpg

description: Bulletin of 1937/05/31
DOI: 10.13130/rd_unimi/pddrps/guoefq
title: Maggio_1937_Pagina_303.jpg

description: Bulletin of 1937/05/31
DOI: 10.13130/rd_unimi/pddrps/ib171v
title: Maggio_1937_Pagina_304.jpg

description: Bulletin of 1937/05/31
DOI: 10.13130/rd_unimi/pddrps/hdsj5h
title: Maggio_1937_Pagina_305.jpg

description: Bulletin of 1937/05/31
DOI: 10.13130/rd_unimi/pddrps/n1k1jn
title: Maggio_1937_Pagina_306.jpg

description: Bulletin of 1937/05/31
DOI: 10.13130/rd_unimi/pddrps/tliw8h
title: Maggio_1937_Pagina_307.jpg

description: Bulletin of 1937/05/31
DOI: 10.13130/rd_unimi/pddrps/as4ji9
title: Maggio_1937_Pagina_308.jpg

description: Bulletin of 1937/05/31
DOI: 10.13130/rd_unimi/pddrps/aeptvu
title: Maggio_1937_Pagina_310.jpg

description: Bulletin of 1937/05/31
DOI: 10.13130/rd_unimi/pddrps/rnnv83
title: Maggio_1937_Pagina_309.jpg

description: Bulletin of 1937/05/31
DOI: 10.13130/rd_unimi/pddrps/vtldop
title: Marzo_1937_Pagina_001.jpg

description: Bulletin of 1937/03/01
DOI: 10.13130/rd_unimi/pddrps/whj66m
title: Marzo_1937_Pagina_002.jpg

description: Bulletin of 1937/03/01
DOI: 10.13130/rd_unimi/pddrps/x0ipvw
title: Marzo_1937_Pagina_003.jpg

description: Bulletin of 1937/03/01
DOI: 10.13130/rd_unimi/pddrps/rkl8ig
title: Marzo_1937_Pagina_004.jpg

description: Bulletin of 1937/03/01
DOI: 10.13130/rd_unimi/pddrps/wyxuxq
title: Marzo_1937_Pagina_005.jpg

description: Bulletin of 1937/03/01
DOI: 10.15468/dl.w89wm8
title: Occurrence Download

description: A dataset containing 14754 species occurrences available in GBIF matching the query:
{
 "and" : [
 "GadmGid is one of (ARG, CHL, PRY, URY, FLK, BRA.21_1, BRA.16_1, BRA.24_1)",
 "TaxonKey is Brassicaceae"
 ]
}

 The dataset includes 14754 records from 168 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0010147-251120083545085/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.13130/rd_unimi/pddrps/y2qzlk
title: Marzo_1937_Pagina_006.jpg

description: Bulletin of 1937/03/01
DOI: 10.13130/rd_unimi/pddrps/y8bvma
title: Marzo_1937_Pagina_007.jpg

description: Bulletin of 1937/03/01
DOI: 10.13130/rd_unimi/pddrps/hbh5tv
title: Marzo_1937_Pagina_008.jpg

description: Bulletin of 1937/03/01
DOI: 10.13130/rd_unimi/pddrps/ma461l
title: Marzo_1937_Pagina_009.jpg

description: Bulletin of 1937/03/01
DOI: 10.13130/rd_unimi/pddrps/zdarcw
title: Marzo_1937_Pagina_010.jpg

description: Bulletin of 1937/03/01
DOI: 10.13130/rd_unimi/pddrps/3cg4ta
title: Marzo_1937_Pagina_011.jpg

description: Bulletin of 1937/03/02
DOI: 10.5281/zenodo.17725476
title: Structures and files for MD simulations of ternary complexes FKBP12-FRAP-rapamycin and FKBP12-CEP250-WDB002

description: The directory contains the structures and files used to start molecular dynamics simulations of apo and holo forms of the ternary complexes FKBP12-FRAP-rapamycin and FKBP12-CEP250-WDB002 as well as the binary complexes: FKBP12-rapamycin, FRAP-rapamycin, FKBP12-WDB002 and CEP250-WDB002. The files required to calculate the MM/GBSA binding free energies and frequency of occurrence of water-mediated hydrogen bonds between protein chains are also included.

 Details about the modeling and simulations can be found in the paper: 

Molecular glues stabilize water-mediated hydrogen bonds in ternary complexes-Apoorva Mathur, Mariona Alegre Canela, Max von Graevenitz, Chiara Gerstner, Ariane Nunes-Alves*
DOI: 10.13130/rd_unimi/pddrps/8xiqqy
title: Marzo_1937_Pagina_012.jpg

description: Bulletin of 1937/03/02
DOI: 10.13130/rd_unimi/pddrps/crdfne
title: Marzo_1937_Pagina_013.jpg

description: Bulletin of 1937/03/02
DOI: 10.13130/rd_unimi/pddrps/ndt7og
title: Marzo_1937_Pagina_014.jpg

description: Bulletin of 1937/03/02
DOI: 10.13130/rd_unimi/pddrps/hrdae6
title: Marzo_1937_Pagina_015.jpg

description: Bulletin of 1937/03/02
DOI: 10.13130/rd_unimi/pddrps/vyik1f
title: Marzo_1937_Pagina_016.jpg

description: Bulletin of 1937/03/02
DOI: 10.13130/rd_unimi/pddrps/zmm2d1
title: Marzo_1937_Pagina_017.jpg

description: Bulletin of 1937/03/02
DOI: 10.13130/rd_unimi/pddrps/raexkl
title: Marzo_1937_Pagina_018.jpg

description: Bulletin of 1937/03/02
DOI: 10.13130/rd_unimi/pddrps/xlfpwt
title: Marzo_1937_Pagina_019.jpg

description: Bulletin of 1937/03/02
DOI: 10.13130/rd_unimi/pddrps/u3zozw
title: Marzo_1937_Pagina_020.jpg

description: Bulletin of 1937/03/02
DOI: 10.13130/rd_unimi/pddrps/76rrv7
title: Marzo_1937_Pagina_022.jpg

description: Bulletin of 1937/03/03
DOI: 10.13130/rd_unimi/pddrps/fqefks
title: Marzo_1937_Pagina_021.jpg

description: Bulletin of 1937/03/03
DOI: 10.13130/rd_unimi/pddrps/on3pfg
title: Marzo_1937_Pagina_023.jpg

description: Bulletin of 1937/03/03
DOI: 10.13130/rd_unimi/pddrps/aim3lk
title: Marzo_1937_Pagina_025.jpg

description: Bulletin of 1937/03/03
DOI: 10.13130/rd_unimi/pddrps/ozsidp
title: Marzo_1937_Pagina_024.jpg

description: Bulletin of 1937/03/03
DOI: 10.13130/rd_unimi/pddrps/42vrs0
title: Marzo_1937_Pagina_026.jpg

description: Bulletin of 1937/03/03
DOI: 10.13130/rd_unimi/pddrps/qhyjif
title: Marzo_1937_Pagina_027.jpg

description: Bulletin of 1937/03/03
DOI: 10.13130/rd_unimi/pddrps/0fzioh
title: Marzo_1937_Pagina_029.jpg

description: Bulletin of 1937/03/03
DOI: 10.13130/rd_unimi/pddrps/4ylr6l
title: Marzo_1937_Pagina_028.jpg

description: Bulletin of 1937/03/03
DOI: 10.13130/rd_unimi/pddrps/ecwgdj
title: Marzo_1937_Pagina_030.jpg

description: Bulletin of 1937/03/03
DOI: 10.13130/rd_unimi/pddrps/twolka
title: Marzo_1937_Pagina_031.jpg

description: Bulletin of 1937/03/04
DOI: 10.35097/kam044sfpb43ektf
title: Robust Bilinear Rotations II - Data

description: Spectra in JCAMP-DX and Bruker format together with Bruker pulse programs used for acquisition of example NMR spectra.
DOI: 10.13130/rd_unimi/pddrps/khh73f
title: Marzo_1937_Pagina_032.jpg

description: Bulletin of 1937/03/04
DOI: 10.13130/rd_unimi/pddrps/2nqnbm
title: Marzo_1937_Pagina_033.jpg

description: Bulletin of 1937/03/04
DOI: 10.13130/rd_unimi/pddrps/xerhgx
title: Marzo_1937_Pagina_034.jpg

description: Bulletin of 1937/03/04
DOI: 10.13130/rd_unimi/pddrps/9mksmy
title: Marzo_1937_Pagina_035.jpg

description: Bulletin of 1937/03/04
DOI: 10.13130/rd_unimi/pddrps/xenzx2
title: Marzo_1937_Pagina_036.jpg

description: Bulletin of 1937/03/04
DOI: 10.13130/rd_unimi/pddrps/xgqr81
title: Marzo_1937_Pagina_037.jpg

description: Bulletin of 1937/03/04
DOI: 10.13130/rd_unimi/pddrps/hygxav
title: Marzo_1937_Pagina_038.jpg

description: Bulletin of 1937/03/04
DOI: 10.13130/rd_unimi/pddrps/nisi3w
title: Marzo_1937_Pagina_040.jpg

description: Bulletin of 1937/03/04
DOI: 10.13130/rd_unimi/pddrps/r6yll3
title: Marzo_1937_Pagina_039.jpg

description: Bulletin of 1937/03/04
DOI: 10.13130/rd_unimi/pddrps/xsuduc
title: Marzo_1937_Pagina_041.jpg

description: Bulletin of 1937/03/05
DOI: 10.13130/rd_unimi/pddrps/hjlt3q
title: Marzo_1937_Pagina_042.jpg

description: Bulletin of 1937/03/05
DOI: 10.13130/rd_unimi/pddrps/ijsb2f
title: Marzo_1937_Pagina_043.jpg

description: Bulletin of 1937/03/05
DOI: 10.13130/rd_unimi/pddrps/umkblt
title: Marzo_1937_Pagina_044.jpg

description: Bulletin of 1937/03/05
DOI: 10.15468/dl.mz4zzk
title: Occurrence Download

description: A dataset containing 925 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Lithocarpus konishii"
 ]
}

 The dataset includes 925 records from 31 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0010149-251120083545085/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.13130/rd_unimi/pddrps/0kkjbs
title: Marzo_1937_Pagina_045.jpg

description: Bulletin of 1937/03/05
DOI: 10.15468/dl.whzqs9
title: Occurrence Download

description: A dataset containing 1253230809 species occurrences available in GBIF matching the query:
{
 "Continent" : [
 "is Europe"
 ]
}

 The dataset includes 1253230809 records from 38278 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0009838-251120083545085/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.hy95w5
title: Occurrence Download

description: A dataset containing 26 species occurrences available in GBIF matching the query:
{
 "and" : [
 "GadmGid is DEU.9_1",
 "OccurrenceStatus is Present",
 "TaxonKey is Muscardinus avellanarius (Linnaeus, 1758)",
 "Year 1994-2025"
 ]
}

 The dataset includes 26 records from 3 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0009809-250515123054153/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.25326/g1c2-m811
title: cis-3-hexen-1-ol+hono + OH - Aerosol study - particle formation - 2008-07-29

description: Publication of the dataset
DOI: 10.25326/sw6w-0n28
title: alpha-pinene+NOx + O3 - Aerosol study - physical properties - 2012-02-09

description: Publication of the dataset
DOI: 10.25326/c9qr-kp31
title: beta-caryophllene+no+no2 + OH - Aerosol study - physical properties - 2012-03-29

description: Publication of the dataset
DOI: 10.25326/yt71-a133
title: beta-caryophyllene+NO+NO2 + O3 - Aerosol study - physical properties - 2012-06-05

description: Publication of the dataset
DOI: 10.25326/76nx-7k07
title: alpha-pinene+no+no2 + OH - Aerosol study - physical properties - 2012-04-23

description: Publication of the dataset
DOI: 10.25326/gphw-pp16
title: beta-caryophyllene+NO+NO2 + O3 - Aerosol study - physical properties - 2012-06-07

description: Publication of the dataset
DOI: 10.25326/y2nf-a217
title: limonene+o3+no+no2 + OH - Aerosol study - physical properties - 2012-11-23

description: Publication of the dataset
DOI: 10.25326/1h0s-7c84
title: alpha-pinene+NOx + O3 - Aerosol study - physical properties - 2012-05-31

description: Publication of the dataset
DOI: 10.25326/g56t-4s25
title: limonene+beta-caryophyllene+NO+NO2 + O3 - Aerosol study - physical properties - 2012-12-05

description: Publication of the dataset
DOI: 10.25326/d1bc-8b44
title: cis-3-hexenal + O3 -  - 2009-03-25

description: Publication of the dataset
DOI: 10.25326/6x5b-5n79
title: trans-2-butene+carbon monoxide + O3 -  - 2002-06-08

description: Publication of the dataset
DOI: 10.25326/n8wk-6e30
title: beta-caryophllene+no+no2 + OH - Aerosol study - physical properties - 2008-04-23

description: Publication of the dataset
DOI: 10.25326/byb5-bn35
title: nn-diisopropylaniline+isoprene+octane+ozone + OH - Gas-phase oxidation - kinetic study - 2011-02-03

description: Publication of the dataset
DOI: 10.15468/dl.gsgf7b
title: Occurrence Download

description: A dataset containing 644 species occurrences available in GBIF matching the query:
{
 "and" : [
 "BasisOfRecord is Human Observation",
 "Country is Spain",
 "TaxonKey is Orchis ustulata L."
 ]
}

 The dataset includes 644 records from 8 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0013828-250515123054153/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.25934/pr00005674.3
title: Available IPD datapackage for study 'A Randomized, Double-blind Study of the Effect of Tocilizumab on Reduction in Signs and Symptoms in Patients With Moderate to Severe Active Rheumatoid Arthritis and Inadequate Response to DMARD Therapy'

description: This 2 arm study will compare the safety and efficacy, with regard to reduction of signs and symptoms, of tocilizumab versus placebo in combination with traditional Disease-Modifying Anti-Rheumatic Drug (DMARD) therapy in patients with moderate to severe active rheumatoid arthritis (RA) who have had an inadequate response to current DMARD therapy. Patients will be randomized to receive tocilizumab 8mg/kg iv or placebo iv every 4 weeks, in conjunction with stable DMARD therapy. The anticipated time on study treatment is 3-12 months, and the target sample size is 500+ individuals.