cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.7770383.v2
title: Cell lineage-specific genome-wide DNA methylation analysis of patients with paediatric-onset systemic lupus erythematosus

description: Patients with paediatric-onset systemic lupus erythematosus (SLE) often present with more severe clinical courses than adult-onset patients. Although genome-wide DNA methylation (DNAm) profiling has been performed in adult-onset SLE patients, parallel data on paediatric-onset SLE are not available. Therefore, we undertook a genome-wide DNAm study in paediatric-onset SLE patients across multiple blood cell lineages. The DNAm profiles of four purified immune cell lineages (CD4 + T cells, CD8 + T cells, B cells and neutrophils) and whole blood were compared in 16 Chinese patients with paediatric-onset SLE and 13 healthy controls using the Illumina HumanMethylationEPIC BeadChip. Comparison of DNAm in whole blood and within each independent cell lineage identified a consistent pattern of loss of DNAm at 21 CpG sites overlapping 15 genes, which represented a robust, disease-specific DNAm signature for paediatric-onset SLE in our cohort. In addition, cell lineage-specific changes, involving both loss and gain of DNAm, were observed in both novel genes and genes with well-described roles in SLE pathogenesis. This study also highlights the importance of studying DNAm changes in different immune cell lineages rather than only whole blood, since cell type-specific DNAm changes facilitated the elucidation of the cell type-specific molecular pathophysiology of SLE.
DOI: 10.6084/m9.figshare.7850735.v2
title: DNA methylation changes associated with Parkinson’s disease progression: outcomes from the first longitudinal genome-wide methylation analysis in blood

description: Parkinson’s Disease (PD) is a common neurodegenerative disorder currently diagnosed based on the presentation of characteristic movement symptoms. Unfortunately, patients exhibiting these symptoms have already undergone significant dopaminergic neuronal loss. Earlier diagnosis, aided by molecular biomarkers specific to PD, would improve overall patient care. Epigenetic mechanisms, which are modified by both environment and disease pathophysiology, are emerging as important components of neurodegeneration. Alterations to the PD methylome have been reported in epigenome-wide association studies. However, the extent to which methylation changes correlate with disease progression has not yet been reported; nor the degree to which methylation is affected by PD medication. We performed a longitudinal genome-wide methylation study surveying ~850,000 CpG sites in whole blood from 189 well-characterized PD patients and 191 control individuals obtained at baseline and at a follow-up visit ~2 y later. We identified distinct patterns of methylation in PD cases versus controls. Importantly, we identified genomic sites where methylation changes longitudinally as the disease progresses. Moreover, we identified methylation changes associated with PD pathology through the analysis of PD cases that were not exposed to anti-parkinsonian therapy. In addition, we identified methylation sites modulated by exposure to dopamine replacement drugs. These results indicate that DNA methylation is dynamic in PD and changes over time during disease progression. To the best of our knowledge, this is the first longitudinal epigenome-wide methylation analysis for Parkinson’s disease and reveals changes associated with disease progression and in response to dopaminergic medications in the blood methylome.
DOI: 10.6084/m9.figshare.7850735
title: DNA methylation changes associated with Parkinson’s disease progression: outcomes from the first longitudinal genome-wide methylation analysis in blood

description: Parkinson’s Disease (PD) is a common neurodegenerative disorder currently diagnosed based on the presentation of characteristic movement symptoms. Unfortunately, patients exhibiting these symptoms have already undergone significant dopaminergic neuronal loss. Earlier diagnosis, aided by molecular biomarkers specific to PD, would improve overall patient care. Epigenetic mechanisms, which are modified by both environment and disease pathophysiology, are emerging as important components of neurodegeneration. Alterations to the PD methylome have been reported in epigenome-wide association studies. However, the extent to which methylation changes correlate with disease progression has not yet been reported; nor the degree to which methylation is affected by PD medication. We performed a longitudinal genome-wide methylation study surveying ~850,000 CpG sites in whole blood from 189 well-characterized PD patients and 191 control individuals obtained at baseline and at a follow-up visit ~2 y later. We identified distinct patterns of methylation in PD cases versus controls. Importantly, we identified genomic sites where methylation changes longitudinally as the disease progresses. Moreover, we identified methylation changes associated with PD pathology through the analysis of PD cases that were not exposed to anti-parkinsonian therapy. In addition, we identified methylation sites modulated by exposure to dopamine replacement drugs. These results indicate that DNA methylation is dynamic in PD and changes over time during disease progression. To the best of our knowledge, this is the first longitudinal epigenome-wide methylation analysis for Parkinson’s disease and reveals changes associated with disease progression and in response to dopaminergic medications in the blood methylome.
DOI: 10.6084/m9.figshare.7850735.v1
title: DNA methylation changes associated with Parkinson’s disease progression: outcomes from the first longitudinal genome-wide methylation analysis in blood

description: Parkinson’s Disease (PD) is a common neurodegenerative disorder currently diagnosed based on the presentation of characteristic movement symptoms. Unfortunately, patients exhibiting these symptoms have already undergone significant dopaminergic neuronal loss. Earlier diagnosis, aided by molecular biomarkers specific to PD, would improve overall patient care. Epigenetic mechanisms, which are modified by both environment and disease pathophysiology, are emerging as important components of neurodegeneration. Alterations to the PD methylome have been reported in epigenome-wide association studies. However, the extent to which methylation changes correlate with disease progression has not yet been reported; nor the degree to which methylation is affected by PD medication. We performed a longitudinal genome-wide methylation study surveying ~850,000 CpG sites in whole blood from 189 well-characterized PD patients and 191 control individuals obtained at baseline and at a follow-up visit ~2 y later. We identified distinct patterns of methylation in PD cases versus controls. Importantly, we identified genomic sites where methylation changes longitudinally as the disease progresses. Moreover, we identified methylation changes associated with PD pathology through the analysis of PD cases that were not exposed to anti-parkinsonian therapy. In addition, we identified methylation sites modulated by exposure to dopamine replacement drugs. These results indicate that DNA methylation is dynamic in PD and changes over time during disease progression. To the best of our knowledge, this is the first longitudinal epigenome-wide methylation analysis for Parkinson’s disease and reveals changes associated with disease progression and in response to dopaminergic medications in the blood methylome.
DOI: 10.6084/m9.figshare.21346818.v2
title: Extended Data 1

description: Overview of patient avatar characteristics in the testing scenarios implemented in the study
DOI: 10.6084/m9.figshare.21905181.v1
title: Extended Data 3

description: All implemented questionnaire items to assess students' perception of simulation design and satisfaction and self-donfidence in learning with simulations
DOI: 10.6084/m9.figshare.21346827.v2
title: Extended Data 2

description: All implemented mulitple-choice questions
DOI: 10.6084/m9.figshare.21346869.v2
title: Extended Data 5

description: Descriptives of performed complementary ANCOVAs
DOI: 10.6084/m9.figshare.21857826
title: Test.xlsx

description: This is a test
DOI: 10.6084/m9.figshare.21857826.v2
title: Test.xlsx

description: This is a test
DOI: 10.6084/m9.figshare.21857826.v1
title: Test.xlsx

description: This is a test
DOI: 10.6084/m9.figshare.21346878.v2
title: Extended Data 11

description: Fidelity comparison of cohorts to criteria which make the preparation for future learning instructional design superior to others
DOI: 10.15472/m1c5nc
title: Listado de las especies de Dytiscidae (Coleoptera: Adephaga) de Colombia

description: Este recurso presenta el listado de las especies de la familia Dytiscidae (Coleoptera: Adephaga) con ocurrencia conocida para el territorio colombiano. Se listan ocho subfamilias, 17 tribus, 32 géneros, cuatro subgéneros, 64 especies y dos subespecies. 24 especies son consideradas endémicas. El listado ha sido compilado a partir de información disponible en los principales catálogos que tratan del grupo y en literatura reciente. Se incluyen las referencias de todas las descripciones originales y de los trabajos de revisión taxonómica.
DOI: 10.5519/qd.uiwqsm39
title: Query on the Natural History Museum Data Portal (data.nhm.ac.uk) (1 records)
DOI: 10.5519/qd.ecfzmzof
title: Query on the Natural History Museum Data Portal (data.nhm.ac.uk) (1 records)
DOI: 10.6084/m9.figshare.21346818.v3
title: Supplementary Materials 1

description: Overview of patient avatar characteristics in the testing scenarios implemented in the study
DOI: 10.6084/m9.figshare.21346827.v3
title: Supplementary Materials 2

description: All implemented mulitple-choice questions
DOI: 10.6084/m9.figshare.21905181.v2
title: Supplementary Materials 3

description: All implemented questionnaire items to assess students' perception of simulation design and satisfaction and self-donfidence in learning with simulations
DOI: 10.6084/m9.figshare.21346854.v3
title: Supplementary Materials 4

description: Descriptives of all measures
DOI: 10.6084/m9.figshare.21346869.v3
title: Supplementary Materials 5

description: Descriptives of performed complementary ANCOVAs
DOI: 10.6084/m9.figshare.21916191
title: GWAS for urine Ade

description: Gwas of urine Ade
DOI: 10.6084/m9.figshare.21916191.v1
title: GWAS for urine Ade

description: Gwas of urine Ade
DOI: 10.6084/m9.figshare.21346878.v3
title: Supplementary Materials 11

description: Fidelity comparison of cohorts to criteria which make the preparation for future learning instructional design superior to others
DOI: 10.6084/m9.figshare.21913221
title: Scripts and description of bioinformatic analyses from Tagirdzhanova et al. 2023

description: Supplementary files associated with Tagirdzhanova et al. 2023. A global survey of lichen symbionts from metagenomes. <br> Contains scripts used in the analysis. Each script and its function, along with the rationale of the analysis is described in README.txt <br> This is also available as a GitHub repo https://github.com/Spribille-lab/A-global-survey-of-lichen-symbionts-from-metagenomes
DOI: 10.6084/m9.figshare.21913221.v1
title: Scripts and description of bioinformatic analyses from Tagirdzhanova et al. 2023

description: Supplementary files associated with Tagirdzhanova et al. 2023. A global survey of lichen symbionts from metagenomes. <br> Contains scripts used in the analysis. Each script and its function, along with the rationale of the analysis is described in README.txt <br> This is also available as a GitHub repo https://github.com/Spribille-lab/A-global-survey-of-lichen-symbionts-from-metagenomes
DOI: 10.6084/m9.figshare.21916143.v1
title: impala_dung_middens_geolocation

description: Primary data used to develop 'Decorum in nature: impala (Aepyceros melampus melampus) dung middens follow spatial point patterns in Mukuvisi Woodlands, Zimbabwe'. Coordinates are in UTM Zone 36 S.
DOI: 10.6084/m9.figshare.21916143
title: impala_dung_middens_geolocation

description: Primary data used to develop 'Decorum in nature: impala (Aepyceros melampus melampus) dung middens follow spatial point patterns in Mukuvisi Woodlands, Zimbabwe'. Coordinates are in UTM Zone 36 S.
DOI: 10.5517/ccdc.csd.cc2c1jwv
title: CCDC 2176227: Experimental Crystal Structure Determination

description: Related Article: Hongdao Li, Chaoyi Jin, Jing Han, Lu Xi, Zhenjun Song|2022|Cryst.Growth Des.|23|612|doi:10.1021/acs.cgd.2c01208
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2c1jxw
title: CCDC 2176228: Experimental Crystal Structure Determination

description: Related Article: Hongdao Li, Chaoyi Jin, Jing Han, Lu Xi, Zhenjun Song|2022|Cryst.Growth Des.|23|612|doi:10.1021/acs.cgd.2c01208
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2c1jyx
title: CCDC 2176229: Experimental Crystal Structure Determination

description: Related Article: Hongdao Li, Chaoyi Jin, Jing Han, Lu Xi, Zhenjun Song|2022|Cryst.Growth Des.|23|612|doi:10.1021/acs.cgd.2c01208
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2c1jzy
title: CCDC 2176230: Experimental Crystal Structure Determination

description: Related Article: Hongdao Li, Chaoyi Jin, Jing Han, Lu Xi, Zhenjun Song|2022|Cryst.Growth Des.|23|612|doi:10.1021/acs.cgd.2c01208
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.6084/m9.figshare.21916248
title: Untitled Item

description: Abbrevation of 272 NUTS2 regions
DOI: 10.6084/m9.figshare.21916248.v1
title: Untitled Item

description: Abbrevation of 272 NUTS2 regions
DOI: 10.6084/m9.figshare.21610323
title: Bauchi State Health Facility Assessment Tool

description: The tenet of Universal Health Coverage (UHC) in the post-2015 development agenda re-emphasizes distributional equity and efficiency in healthcare service delivery by providing technical and financial support to healthcare facilities at all levels. Effective delivery of healthcare services requires adequate infrastructure, diagnostic medical equipment, drugs, and well-trained medical personnel. Thus it becomes imperative to conduct a health facility assessment in Bauchi State to generate data on health service availability and service readiness of health facilities across the state. The study involved an assessment of the perception of relevant stakeholders on the role of Community Pharmacists and Patent Proprietary Medical Vendors (PPMVs) on the Bauchi State Health Contributory Management Agency (BASHCMA) scheme. The assessment results provided a situational analysis of the current status of health facilities in terms of infrastructure, HRH, and available health services that can be used for decision-making.
DOI: 10.6084/m9.figshare.21610323.v1
title: Bauchi State Health Facility Assessment Tool

description: The tenet of Universal Health Coverage (UHC) in the post-2015 development agenda re-emphasizes distributional equity and efficiency in healthcare service delivery by providing technical and financial support to healthcare facilities at all levels. Effective delivery of healthcare services requires adequate infrastructure, diagnostic medical equipment, drugs, and well-trained medical personnel. Thus it becomes imperative to conduct a health facility assessment in Bauchi State to generate data on health service availability and service readiness of health facilities across the state. The study involved an assessment of the perception of relevant stakeholders on the role of Community Pharmacists and Patent Proprietary Medical Vendors (PPMVs) on the Bauchi State Health Contributory Management Agency (BASHCMA) scheme. The assessment results provided a situational analysis of the current status of health facilities in terms of infrastructure, HRH, and available health services that can be used for decision-making.
DOI: 10.5523/bris.27ui6v0q9a69y2ekvtrdueserp
title: Qin et al Communications Bio

description: Supplementary data for Qin et al. 2023 Communications Biology dinosaur claw function
DOI: 10.5281/zenodo.7545048
title: Data: Thermodiffusion of aqueous solutions of various potassium salts

description: Data, which are presented in the following publication: Mohanakumar, Shilpa; Luettmer-Strathmann, Jutta; Wiegand, Simone (2021): Thermodiffusion of aqueous solutions of various potassium salts. In: J Chem Phys 154 (8), S. 84506. DOI: 10.1063/5.0038039.
DOI: 10.5281/zenodo.7545047
title: Data: Thermodiffusion of aqueous solutions of various potassium salts

description: Data, which are presented in the following publication: Mohanakumar, Shilpa; Luettmer-Strathmann, Jutta; Wiegand, Simone (2021): Thermodiffusion of aqueous solutions of various potassium salts. In: J Chem Phys 154 (8), S. 84506. DOI: 10.1063/5.0038039.
DOI: 10.5281/zenodo.7545078
title: Data: Towards understanding specific ion effects in aqueous media using thermodiffusion

description: Data, which are presented in the following publication: Mohanakumar, Shilpa; Wiegand, Simone (2022): Towards understanding specific ion effects in aqueous media using thermodiffusion. In: The Eur. Phys. J. E 45 (2), S. 10. DOI: 10.1140/epje/s10189-022-00164-8.
DOI: 10.5281/zenodo.7545077
title: Data: Towards understanding specific ion effects in aqueous media using thermodiffusion

description: Data, which are presented in the following publication: Mohanakumar, Shilpa; Wiegand, Simone (2022): Towards understanding specific ion effects in aqueous media using thermodiffusion. In: The Eur. Phys. J. E 45 (2), S. 10. DOI: 10.1140/epje/s10189-022-00164-8.
DOI: 10.5281/zenodo.7545116
title: Data: Overlapping hydration shells in salt solutions causing non-monotonic Soret coefficients with varying concentration

description: Data, which are presented in the following publication: Mohanakumar, Shilpa; Kriegs, Hartmut; Briels, W. J.; Wiegand, Simone (2022): Overlapping hydration shells in salt solutions causing non-monotonic Soret coefficients with varying concentration. In: Physical chemistry chemical physics : PCCP 24, S. 27380–27387. DOI: 10.1039/D2CP04089A.
DOI: 10.5281/zenodo.7545115
title: Data: Overlapping hydration shells in salt solutions causing non-monotonic Soret coefficients with varying concentration

description: Data, which are presented in the following publication: Mohanakumar, Shilpa; Kriegs, Hartmut; Briels, W. J.; Wiegand, Simone (2022): Overlapping hydration shells in salt solutions causing non-monotonic Soret coefficients with varying concentration. In: Physical chemistry chemical physics : PCCP 24, S. 27380–27387. DOI: 10.1039/D2CP04089A.
DOI: 10.5281/zenodo.7545093
title: Data: Thermophoretic microfluidic cells for evaluating Soret coefficient of colloidal particles

description: Data, which are presented in the following publication: Lee, Namkyu; Mohanakumar, Shilpa; Wiegand, Simone (2022): Thermophoretic microfluidic cells for evaluating Soret coefficient of colloidal particles. In: Int J Heat Mass Tran 194, S. 123002. DOI: 10.1016/j.ijheatmasstransfer.2022.123002.
DOI: 10.5281/zenodo.7545092
title: Data: Thermophoretic microfluidic cells for evaluating Soret coefficient of colloidal particles

description: Data, which are presented in the following publication: Lee, Namkyu; Mohanakumar, Shilpa; Wiegand, Simone (2022): Thermophoretic microfluidic cells for evaluating Soret coefficient of colloidal particles. In: Int J Heat Mass Tran 194, S. 123002. DOI: 10.1016/j.ijheatmasstransfer.2022.123002.
DOI: 10.5281/zenodo.7545129
title: Data: Complementary Experimental Methods to Obtain Thermodynamic Parameters of Protein Ligand Systems

description: Data, which are presented in the following publication: Mohanakumar, Shilpa; Lee, Namkyu; Wiegand, Simone (2022): Complementary Experimental Methods to Obtain Thermodynamic Parameters of Protein Ligand Systems. In: International Journal of Molecular Sciences 23 (22), S. 14198. DOI: 10.3390/ijms232214198.
DOI: 10.5281/zenodo.7545128
title: Data: Complementary Experimental Methods to Obtain Thermodynamic Parameters of Protein Ligand Systems

description: Data, which are presented in the following publication: Mohanakumar, Shilpa; Lee, Namkyu; Wiegand, Simone (2022): Complementary Experimental Methods to Obtain Thermodynamic Parameters of Protein Ligand Systems. In: International Journal of Molecular Sciences 23 (22), S. 14198. DOI: 10.3390/ijms232214198.