cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.25549/independent-c69-9046
title: Analyses requested by counsel (1 of 3), 1991 May-June

description: Analyses requested by counsel (1 of 3), 1991 May 15 - June 24. PART OF A SERIES: To ascertain misconduct on the part of LAPD officers, the Independent Commission set out to probe databases maintained by the LAPD related to four areas: personnel complaints, use of force, officer-involved shootings (OIS), and the use of dogs (K-9). This task was delegated to the firm Freeman & Mills, which was responsible for obtaining these databases from the LAPD, converting pertinent data into useable formats, creating additional databases of additional information, and analyzing its findings. The series contains items related to Freeman & Mills' work product, including numerous analyses of use-of-force, OIS, and K-9 data; weekly complaint summary printouts; graphs, charts, tables, and other visual representations of this data; and computer directory lists that provide the names and locations of files within the LAPD's databases. At the end of the series is a draft copy of the Independent Commission's final report, which incorporates many of the aforementioned data and figures.
DOI: 10.15468/dl.edxkyr
title: Occurrence Download

description: A dataset containing 8821 species occurrences available in GBIF matching the query:
{
 "and" : [
 "DatasetKey is iNaturalist Research-grade Observations",
 "TaxonKey is Sequoia sempervirens (D.Don) Endl."
 ]
}

 The dataset includes 8821 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0174437-230224095556074/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.25549/independent-c69-9121
title: Analysis (1 of 4), 1988-1991 June

description: Analysis (1 of 4), 1988 August - 1991 June 25. Duplicates (Some may be superceded). PART OF A SERIES: To ascertain misconduct on the part of LAPD officers, the Independent Commission set out to probe databases maintained by the LAPD related to four areas: personnel complaints, use of force, officer-involved shootings (OIS), and the use of dogs (K-9). This task was delegated to the firm Freeman & Mills, which was responsible for obtaining these databases from the LAPD, converting pertinent data into useable formats, creating additional databases of additional information, and analyzing its findings. The series contains items related to Freeman & Mills' work product, including numerous analyses of use-of-force, OIS, and K-9 data; weekly complaint summary printouts; graphs, charts, tables, and other visual representations of this data; and computer directory lists that provide the names and locations of files within the LAPD's databases. At the end of the series is a draft copy of the Independent Commission's final report, which incorporates many of the aforementioned data and figures.
DOI: 10.15468/dl.excgmc
title: Occurrence Download

description: A dataset containing 38153 species occurrences available in GBIF matching the query:
{
 "Country" : [
 "is North Macedonia"
 ]
}

 The dataset includes 38153 records from 247 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0001246-170714134226665/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.ya9yrh
title: Occurrence Download

description: A dataset containing 36515 species occurrences available in GBIF matching the query:
{
 "DatasetKey" : [
 "is Taxon occurrence data for the FungalRoot database"
 ]
}

 The dataset includes 36515 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0174441-230224095556074/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.25549/independent-c69-9108
title: Analysis (1 of 4), 1988-1991 June

description: Analysis (1 of 4), 1988 August - 1991 June 25. Duplicates (Some may be superceded). PART OF A SERIES: To ascertain misconduct on the part of LAPD officers, the Independent Commission set out to probe databases maintained by the LAPD related to four areas: personnel complaints, use of force, officer-involved shootings (OIS), and the use of dogs (K-9). This task was delegated to the firm Freeman & Mills, which was responsible for obtaining these databases from the LAPD, converting pertinent data into useable formats, creating additional databases of additional information, and analyzing its findings. The series contains items related to Freeman & Mills' work product, including numerous analyses of use-of-force, OIS, and K-9 data; weekly complaint summary printouts; graphs, charts, tables, and other visual representations of this data; and computer directory lists that provide the names and locations of files within the LAPD's databases. At the end of the series is a draft copy of the Independent Commission's final report, which incorporates many of the aforementioned data and figures.
DOI: 10.6084/m9.figshare.25769994
title: <b>Genomic Prediction and Genome-wide Association Studies in Korean Sapsaree Dogs</b>

description: <b>Korean Sapsaree </b><b>Illumina 170K CanineHD BeadChip</b><b> Data</b><b><i>Dataset Overview:</i></b> This dataset contains genomic data from a group of Korean Sapsaree dogs. It specifically includes genetic information from 234 individual dogs, each genotyped using the Illumina 170K CanineHD BeadChip.<br><b><i>Files Included:</i></b><b>Sapsaree.fasta:</b> This file contains the genotypic data of the Korean Sapsaree dogs in FASTA format, a widely used text-based format for representing nucleotide sequences. Each entry corresponds to a single dog, with headers that provide identifying information followed by the sequence data.<br><b><i>Purpose of the Dataset:</i></b>The main purpose of releasing this dataset is to enhance the scientific understanding of Sapsaree dogs. By making these data available, we aim to support further research into canine genetics and breeding strategies that can lead to improvements in canine health and traits. Access to the data for reproducing results requires an application to, and permission from, the authors.
DOI: 10.6084/m9.figshare.25769994.v1
title: Sapsaree.fasta

description: <b>Korean Sapsaree </b><b>Illumina 170K CanineHD BeadChip</b><b> Data</b><b><i>Dataset Overview:</i></b> This dataset contains genomic data from a group of Korean Sapsaree dogs. It specifically includes genetic information from 234 individual dogs, each genotyped using the Illumina 170K CanineHD BeadChip.<br><b><i>Files Included:</i></b><b>Sapsaree.fasta:</b> This file contains the genotypic data of the Korean Sapsaree dogs in FASTA format, a widely used text-based format for representing nucleotide sequences. Each entry corresponds to a single dog, with headers that provide identifying information followed by the sequence data.<br><b><i>Purpose of the Dataset:</i></b>The main purpose of releasing this dataset is to enhance the scientific understanding of Sapsaree dogs. By making these data available, we aim to support further research into canine genetics and breeding strategies that can lead to improvements in canine health and traits. Access to the data for reproducing results requires an application to, and permission from, the authors.
DOI: 10.15468/dl.svoekp
title: Occurrence Download

description: A dataset containing 79795 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is Brazil",
 {
 "or" : [
 "Month is September",
 "Month is November",
 "Month is December"
 ]
 },
 "Year 2015-2017",
 "Geometry POLYGON((-58.5 -34,-58.5 -10,-34 -10,-34 -34,-58.5 -34))",
 "HasCoordinate is true",
 "TaxonKey is Aves",
 "HasGeospatialIssue is false"
 ]
}

 The dataset includes 79795 records from 4 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0001246-170822121629195/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.25549/independent-c69-9279
title: Statistical tables for the Commission on the LAPD, 1991 July

description: Statistical tables for the Commission on the LAPD, 1991 July. PART OF A SERIES: To ascertain misconduct on the part of LAPD officers, the Independent Commission set out to probe databases maintained by the LAPD related to four areas: personnel complaints, use of force, officer-involved shootings (OIS), and the use of dogs (K-9). This task was delegated to the firm Freeman & Mills, which was responsible for obtaining these databases from the LAPD, converting pertinent data into useable formats, creating additional databases of additional information, and analyzing its findings. The series contains items related to Freeman & Mills' work product, including numerous analyses of use-of-force, OIS, and K-9 data; weekly complaint summary printouts; graphs, charts, tables, and other visual representations of this data; and computer directory lists that provide the names and locations of files within the LAPD's databases. At the end of the series is a draft copy of the Independent Commission's final report, which incorporates many of the aforementioned data and figures.
DOI: 10.15468/dl.t2b68n
title: Occurrence Download

description: A dataset containing 277 species occurrences available in GBIF matching the query:
{
 "DatasetKey" : [
 "is Norfish: Shetland Cod Fishery 1520-1796"
 ]
}

 The dataset includes 277 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0174431-230224095556074/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.sev4at
title: Occurrence Download

description: A dataset containing 268045 species occurrences available in GBIF matching the query:
{
 "and" : [
 "HasGeospatialIssue is false",
 "HasCoordinate is true",
 "OccurrenceStatus is Present",
 {
 "not" : {
 "BasisOfRecord" : [
 "is one of (Fossil)"
 ]
 }
 },
 "TaxonKey is Calopteryx splendens Harris, 1780"
 ]
}

 The dataset includes 268045 records from 1149 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0174451-230224095556074/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.kkf2uq
title: Occurrence Download

description: A dataset containing 37149508 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is Belgium",
 "HasGeospatialIssue is false",
 "HasCoordinate is true",
 "OccurrenceStatus is Present",
 "Year is greater than or equal to 1900"
 ]
}

 The dataset includes 37149508 records from 704 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0019322-241126133413365/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.ktn8ws
title: Occurrence Download

description: A dataset containing 1 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Lotella maximowiczi Herzenstein, 1896",
 "Geometry POLYGON((170 20, 170 50, 120 50, 120 20, 170 20))",
 "HasCoordinate is true"
 ]
}

 The dataset includes 1 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0019331-241126133413365/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.t9urz5
title: Occurrence Download

description: A dataset containing 62 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is Pakistan",
 "GadmGid is PAK.5_1",
 "TaxonKey is Amaranthus hybridus L."
 ]
}

 The dataset includes 62 records from 3 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0019332-241126133413365/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.ykbrjx
title: Occurrence Download

description: A dataset containing 26 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Liquidambar styraciflua L.",
 "HasGeospatialIssue is false",
 "HasCoordinate is true",
 "OccurrenceStatus is Present",
 "BasisOfRecord is Living Specimen"
 ]
}

 The dataset includes 26 records from 6 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0019334-241126133413365/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.sebr38
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Chrysophrys tumifrons Temminck & Schlegel, 1843",
 "Geometry POLYGON((170 20, 170 50, 120 50, 120 20, 170 20))",
 "HasCoordinate is true"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0019335-241126133413365/datasets/export for details.
DOI: 10.6084/m9.figshare.27628908
title: Design, synthesis and mechanistic exploration of anti-plasmodial Indolo[2,3-<i>b</i>]quinoxaline-7-chloroquinoline hybrids

description: <b>Aim:</b> The aim of this study is to synthesize indolo[2,3-<i>b</i>]quinoxaline-4-aminoquinoline-based hybrids and evaluate their effectiveness against chloroquine-susceptible (3D7) and resistant (W2) <i>Plasmodium falciparum</i> strains, with expected inhibition of <i>P. falciparum</i> chloroquine resistance transporter (<i>Pf</i>CRT) and heme. <b>Methods:</b> The hybrids were synthesized and <i>in vitro</i> evaluated against both susceptible and resistant strains. Molecular docking and studies were conducted to assess the binding affinities for the <i>Pf</i>CRT protein. Additionally, heme-inhibition studies using hemin chloride provided valuable insights into the interaction between the ligand and heme. The binding constant (logK) was calculated, providing quantitative details about the strength of this interaction. <b>Conclusion:</b> The synthesized hybrids showed reasonable potency against both <i>P. falciparum</i> strains. The most potent hybrid <b>10d</b>, with fluorine-substitution exhibited good activity. Molecular docking studies indicated strong binding affinities for the <i>Pf</i>CRT protein. Heme inhibition studies further supported the potential of <b>10d</b> as an effective anti-plasmodial agent. A series of indolo[2,3-<i>b</i>]quinoxaline-7-chloroquinoline based hybrids were designed and synthesized and evaluated for their anti-plasmodial activity. The hybrids were tested against both chloroquine-sensitive (3D7) and chloroquine-resistant (W2) strains of <i>Plasmodium falciparum</i>. The results demonstrated that the compounds exhibited reasonable potency, suggesting that these hybrids could serve as potential candidates for overcoming chloroquine resistance in malaria treatment. Among the series, compound <b>10d</b>, featuring a fluorine substitution, displayed notably superior activity against the chloroquine-resistant W2 strain. Molecular docking studies were conducted to investigate the binding interactions between the synthesized compounds and the <i>Pf</i>CRT protein, a key target in chloroquine resistance. The results indicated that <b>10d</b>, in particular, exhibited strong binding affinities for the <i>Pf</i>CRT protein. Further validation of the anti-plasmodial potential of compound <b>10d</b> was obtained through heme inhibition studies. These studies confirmed that compound <b>10d</b> effectively inhibits heme detoxification within the parasite, thereby enhancing its activity. This dual mode of action underscores the compound's promise as an effective treatment option. Molecular modeling shows that both <b>10d</b> and <b>10f</b> bind strongly to <i>Pf</i>CRT, with <b>10d</b> exhibiting better interaction retention and <b>10f</b> showing promising binding despite lower stability, highlighting their potential as effective <i>Pf</i>CRT inhibitors.
DOI: 10.6084/m9.figshare.27628908.v1
title: Design, synthesis and mechanistic exploration of anti-plasmodial Indolo[2,3-<i>b</i>]quinoxaline-7-chloroquinoline hybrids

description: <b>Aim:</b> The aim of this study is to synthesize indolo[2,3-<i>b</i>]quinoxaline-4-aminoquinoline-based hybrids and evaluate their effectiveness against chloroquine-susceptible (3D7) and resistant (W2) <i>Plasmodium falciparum</i> strains, with expected inhibition of <i>P. falciparum</i> chloroquine resistance transporter (<i>Pf</i>CRT) and heme. <b>Methods:</b> The hybrids were synthesized and <i>in vitro</i> evaluated against both susceptible and resistant strains. Molecular docking and studies were conducted to assess the binding affinities for the <i>Pf</i>CRT protein. Additionally, heme-inhibition studies using hemin chloride provided valuable insights into the interaction between the ligand and heme. The binding constant (logK) was calculated, providing quantitative details about the strength of this interaction. <b>Conclusion:</b> The synthesized hybrids showed reasonable potency against both <i>P. falciparum</i> strains. The most potent hybrid <b>10d</b>, with fluorine-substitution exhibited good activity. Molecular docking studies indicated strong binding affinities for the <i>Pf</i>CRT protein. Heme inhibition studies further supported the potential of <b>10d</b> as an effective anti-plasmodial agent. A series of indolo[2,3-<i>b</i>]quinoxaline-7-chloroquinoline based hybrids were designed and synthesized and evaluated for their anti-plasmodial activity. The hybrids were tested against both chloroquine-sensitive (3D7) and chloroquine-resistant (W2) strains of <i>Plasmodium falciparum</i>. The results demonstrated that the compounds exhibited reasonable potency, suggesting that these hybrids could serve as potential candidates for overcoming chloroquine resistance in malaria treatment. Among the series, compound <b>10d</b>, featuring a fluorine substitution, displayed notably superior activity against the chloroquine-resistant W2 strain. Molecular docking studies were conducted to investigate the binding interactions between the synthesized compounds and the <i>Pf</i>CRT protein, a key target in chloroquine resistance. The results indicated that <b>10d</b>, in particular, exhibited strong binding affinities for the <i>Pf</i>CRT protein. Further validation of the anti-plasmodial potential of compound <b>10d</b> was obtained through heme inhibition studies. These studies confirmed that compound <b>10d</b> effectively inhibits heme detoxification within the parasite, thereby enhancing its activity. This dual mode of action underscores the compound's promise as an effective treatment option. Molecular modeling shows that both <b>10d</b> and <b>10f</b> bind strongly to <i>Pf</i>CRT, with <b>10d</b> exhibiting better interaction retention and <b>10f</b> showing promising binding despite lower stability, highlighting their potential as effective <i>Pf</i>CRT inhibitors.
DOI: 10.6084/m9.figshare.27678991
title: <i>In vivo</i> evaluation of novel synthetic pyrazolones as CDK9 inhibitors with enhanced pharmacokinetic properties

description: <b>Aim:</b> The structural optimization of our recently reported CDK9 inhibitor to furnish novel aminopyrazolones and methylpyrazolones with improved pharmacokinetics. <b>Materials & methods:</b> The synthesis of the targeted compounds was accomplished via conventional, grinding and microwave-assisted processes. The cytotoxicity of them was assayed against three carcinomas. <b>Results:</b> Analogs <b>2</b>, <b>4</b> and <b>6</b> showed significant cytotoxicity and selectivity toward all tested cells. They also displayed potent CDK9 inhibition. Compound <b>6</b> arrested MCF-7 cycle at G2/M phase by stimulating the apoptotic pathway. The <i>in vivo</i> biodistribution of radiolabeled compound <b>6</b> displayed a potent targeting capability of <sup>131</sup>I in solid tumors. <b>Conclusion:</b> Entity <b>6</b> is a potent CDK9 inhibitor where <sup>131</sup>I-compound <b>6</b> can be used as a significant radiopharmaceutical imaging tool for tumors. Structural optimization of diaminopyrazole to furnish novel aminopyrazolones and methylpyrazolones with improved pharmacokinetic properties. Three compounds <b>2</b>, <b>4</b> and <b>6</b> showed significant cytotoxic activity and selectivity toward all tested cancerous cells. Compounds <b>2</b>, <b>4</b> and <b>6</b> also displayed potent CDK9 inhibition with an IC<sub>50</sub> range equal to 0.496–7.149 μM. The most effective CDK9 inhibitor <b>6</b> arrested the cell cycle of MCF-7 at the G2/M phase by stimulating the apoptotic pathway. <i>In vivo</i> biodistribution study of <sup>131</sup>I-<b>6</b> displayed a potent targeting ability of <sup>131</sup>I in solid tumor suggesting that <sup>131</sup>I-<b>6</b> might be used as a promising radiopharmaceutical imaging agent for cancer.
DOI: 10.6084/m9.figshare.27678991.v1
title: <i>In vivo</i> evaluation of novel synthetic pyrazolones as CDK9 inhibitors with enhanced pharmacokinetic properties

description: <b>Aim:</b> The structural optimization of our recently reported CDK9 inhibitor to furnish novel aminopyrazolones and methylpyrazolones with improved pharmacokinetics. <b>Materials & methods:</b> The synthesis of the targeted compounds was accomplished via conventional, grinding and microwave-assisted processes. The cytotoxicity of them was assayed against three carcinomas. <b>Results:</b> Analogs <b>2</b>, <b>4</b> and <b>6</b> showed significant cytotoxicity and selectivity toward all tested cells. They also displayed potent CDK9 inhibition. Compound <b>6</b> arrested MCF-7 cycle at G2/M phase by stimulating the apoptotic pathway. The <i>in vivo</i> biodistribution of radiolabeled compound <b>6</b> displayed a potent targeting capability of <sup>131</sup>I in solid tumors. <b>Conclusion:</b> Entity <b>6</b> is a potent CDK9 inhibitor where <sup>131</sup>I-compound <b>6</b> can be used as a significant radiopharmaceutical imaging tool for tumors. Structural optimization of diaminopyrazole to furnish novel aminopyrazolones and methylpyrazolones with improved pharmacokinetic properties. Three compounds <b>2</b>, <b>4</b> and <b>6</b> showed significant cytotoxic activity and selectivity toward all tested cancerous cells. Compounds <b>2</b>, <b>4</b> and <b>6</b> also displayed potent CDK9 inhibition with an IC<sub>50</sub> range equal to 0.496–7.149 μM. The most effective CDK9 inhibitor <b>6</b> arrested the cell cycle of MCF-7 at the G2/M phase by stimulating the apoptotic pathway. <i>In vivo</i> biodistribution study of <sup>131</sup>I-<b>6</b> displayed a potent targeting ability of <sup>131</sup>I in solid tumor suggesting that <sup>131</sup>I-<b>6</b> might be used as a promising radiopharmaceutical imaging agent for cancer.
DOI: 10.6084/m9.figshare.27966864
title: A toy example for SCAR

description: SeuratData for SRT
DOI: 10.6084/m9.figshare.27966864.v1
title: A toy example for SCAR

description: SeuratData for SRT