cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.5696038.v1
title: Two approaches to calculate TVDI in humid subtropical climate of southern Brazil

description: ABSTRACT: Soybean crops occupy most areas in Rio Grande do Sul State and are highly dependent on rainfall since most of them are non-irrigated. Rainfall during the harvest period is often insufficient to meet the water demand, making water indicators an important tool for the crops. This study compared two approaches in the parameterization process of TVDI (Temperature-Vegetation Dryness Index) in a subtropical climate region of Brazil. The process used Moderate Resolution Imaging Spectroradiometer (MODIS) images of the surface temperature (TS) and Normalized Difference Vegetation Index (NDVI), with spatial resolutions of 1,000 m and periods of 8-16 d, respectively. The evaporative triangles for the TS/NDVI scatter plots were built either for each image (scene-specific parameterization) or for all images at once (crop-type parameterization). The rainfall data were obtained from meteorological stations located in the study site and the analysis period comprised two contrasting harvests regarding soybean yield (most important crop in the region). The scene-specific parameterization allowed to analyze water status in the study site by inspecting the wet and dry edge of each image and identifying the areas of stress in each one. TVDI crop parameterization showed that the model was able to determine the time and frequency of water stress events during the crop-seasons. TVDI crop-parameterization, therefore, is more consistent for crop monitoring and forecasting purposes.
DOI: 10.6084/m9.figshare.5696032
title: In vitro analysis of a local polymeric device as an alternative for systemic antibiotics in Dentistry

description: Abstract The development of a biodegradable material with antimicrobial properties for local applications is required in the prevention and treatment of infectious diseases. The objective of this study was to produce blends of poly-L-lactide acid (PLLA) synthetic polymer associated with several antimicrobials, as an alternative in the prevention and treatment of infections, as well as to evaluate its cytotoxicity, release of antimicrobials and inhibit bacteria growth. Blends of PLLA added with 20% Amoxicillin, Metronidazole, Clindamycin or Azithromicyn were used to produce Films (F) or Meshs (M) by casting and electrospinning methods, respectively. Standardized discs of the films and meshs were stored in buffer solutions (pH 5 or 7.4) and aliquots were analyzed by high performance chromatography (HPLC) during 168 hours. Cytotoxicity on human gingival fibroblasts was tested after 24, 48 and 72h by MTT reaction. The antimicrobial capacity was determined against P. gingivalis and S. pyogenes. The specimens were weighed after 3 and 6 months of storage for degradation analysis. SEM was performed to control interfaces and degradation. Antimicrobials presented a continuous and exponential drug release. Analysis showed that both M and F were able to inhibit S. pyogenes and P. gingivalis growth, indicating the release of active antimicrobial agents. The products were not toxic to the fibroblasts. Amoxicillin-film showed more degradation than PLLA at both pHs (p &lt; 0.05), whereas Azithromycin-meshes were more degraded than PLLA at pH 7.4 (p &lt; 0.05). PLLA association with antimicrobials is biocompatible and may represent a potential tool for the local delivery of antimicrobials.
DOI: 10.6084/m9.figshare.5696032.v1
title: In vitro analysis of a local polymeric device as an alternative for systemic antibiotics in Dentistry

description: Abstract The development of a biodegradable material with antimicrobial properties for local applications is required in the prevention and treatment of infectious diseases. The objective of this study was to produce blends of poly-L-lactide acid (PLLA) synthetic polymer associated with several antimicrobials, as an alternative in the prevention and treatment of infections, as well as to evaluate its cytotoxicity, release of antimicrobials and inhibit bacteria growth. Blends of PLLA added with 20% Amoxicillin, Metronidazole, Clindamycin or Azithromicyn were used to produce Films (F) or Meshs (M) by casting and electrospinning methods, respectively. Standardized discs of the films and meshs were stored in buffer solutions (pH 5 or 7.4) and aliquots were analyzed by high performance chromatography (HPLC) during 168 hours. Cytotoxicity on human gingival fibroblasts was tested after 24, 48 and 72h by MTT reaction. The antimicrobial capacity was determined against P. gingivalis and S. pyogenes. The specimens were weighed after 3 and 6 months of storage for degradation analysis. SEM was performed to control interfaces and degradation. Antimicrobials presented a continuous and exponential drug release. Analysis showed that both M and F were able to inhibit S. pyogenes and P. gingivalis growth, indicating the release of active antimicrobial agents. The products were not toxic to the fibroblasts. Amoxicillin-film showed more degradation than PLLA at both pHs (p &lt; 0.05), whereas Azithromycin-meshes were more degraded than PLLA at pH 7.4 (p &lt; 0.05). PLLA association with antimicrobials is biocompatible and may represent a potential tool for the local delivery of antimicrobials.
DOI: 10.6084/m9.figshare.5696029
title: Hereditary spastic paraplegia from 1880 to 2017: an historical review

description: ABSTRACT The authors have constructed a brief timeline of major clinical research related to hereditary spastic paraplegia (HSP). This timeline summarizes the evolution of HSP research, from the first clinical descriptions by Adolf von Strümpell in 1880 to the present day, with the transformation of these diseases into a rapidly-growing and heterogeneous group of neurogenetic diseases.
DOI: 10.6084/m9.figshare.5696029.v1
title: Hereditary spastic paraplegia from 1880 to 2017: an historical review

description: ABSTRACT The authors have constructed a brief timeline of major clinical research related to hereditary spastic paraplegia (HSP). This timeline summarizes the evolution of HSP research, from the first clinical descriptions by Adolf von Strümpell in 1880 to the present day, with the transformation of these diseases into a rapidly-growing and heterogeneous group of neurogenetic diseases.
DOI: 10.6084/m9.figshare.5696026
title: The challenges faced by the More Doctors Program in providing and ensuring comprehensive health care in rural areas in the Amazon region, Brazil

description: The objective of this research was to assess how the More Doctors Program has been implemented in rural areas and the contributions made by providing physicians to ensure comprehensive health care. A study was conducted in a predominantly rural city in the state of Pará, involving 42 interviews with health professionals and managers, council members and users. The interviews then underwent content analysis. The results suggest that there have been improvements in primary health care – such as a higher number of consultations and expanded access to the primary care services offered – that can be attributed to the presence of the physicians and the use of more equitable strategies. However, there are still challenges to be confronted in order to ensure comprehensive health care in rural areas, such as maintenance of the program and overcoming recurrent problems, such as: lack of drugs and tests; limitations in follow-up on patients referred to other services; and weaknesses in the health care network.
DOI: 10.6084/m9.figshare.5696023
title: The role of the Capuchin Congregation in the formation of regional middle classes and elites

description: Abstract This article discusses the impact of the Capuchin Missionary Sisters educational work on Brazilian middle classes and elites, inscribing this congregation in a larger history, which articulates religious, political and educational matters in the missionary and socio-educational context of the state of Maranhão, in the northeastern region of Brazil, where these women were widely settled. Courageous and skilled, they arrived in a rudimentary mission field and, perhaps for this reason, they had to devote themselves to the formal education of middle classes and regional elites in order to fill regional educational gaps and, at the same time, to constitute the financial and patrimonial capital that would allow them to support the congregation.
DOI: 10.6084/m9.figshare.5696026.v1
title: The challenges faced by the More Doctors Program in providing and ensuring comprehensive health care in rural areas in the Amazon region, Brazil

description: The objective of this research was to assess how the More Doctors Program has been implemented in rural areas and the contributions made by providing physicians to ensure comprehensive health care. A study was conducted in a predominantly rural city in the state of Pará, involving 42 interviews with health professionals and managers, council members and users. The interviews then underwent content analysis. The results suggest that there have been improvements in primary health care – such as a higher number of consultations and expanded access to the primary care services offered – that can be attributed to the presence of the physicians and the use of more equitable strategies. However, there are still challenges to be confronted in order to ensure comprehensive health care in rural areas, such as maintenance of the program and overcoming recurrent problems, such as: lack of drugs and tests; limitations in follow-up on patients referred to other services; and weaknesses in the health care network.
DOI: 10.6084/m9.figshare.5696023.v1
title: The role of the Capuchin Congregation in the formation of regional middle classes and elites

description: Abstract This article discusses the impact of the Capuchin Missionary Sisters educational work on Brazilian middle classes and elites, inscribing this congregation in a larger history, which articulates religious, political and educational matters in the missionary and socio-educational context of the state of Maranhão, in the northeastern region of Brazil, where these women were widely settled. Courageous and skilled, they arrived in a rudimentary mission field and, perhaps for this reason, they had to devote themselves to the formal education of middle classes and regional elites in order to fill regional educational gaps and, at the same time, to constitute the financial and patrimonial capital that would allow them to support the congregation.
DOI: 10.6084/m9.figshare.5696014
title: Transtemporal amygdalohippocampectomy: a novel minimally-invasive technique with optimal clinical results and low cost

description: ABSTRACT Mesial temporal sclerosis creates a focal epileptic syndrome that usually requires surgical resection of mesial temporal structures. Objective: To describe a novel operative technique for treatment of temporal lobe epilepsy and its clinical results. Methods: Prospective case-series at a single institution, performed by a single surgeon, from 2006 to 2012. A total of 120 patients were submitted to minimally-invasive keyhole transtemporal amygdalohippocampectomy. Results: Of the patients, 55% were male, and 85% had a right-sided disease. The first 70 surgeries had a mean surgical time of 2.51 hours, and the last 50 surgeries had a mean surgical time of 1.62 hours. There was 3.3% morbidity, and 5% mild temporal muscle atrophy. There was no visual field impairment. On the Engel Outcome Scale at the two-year follow-up, 71% of the patients were Class I, 21% were Class II, and 6% were Class III. Conclusion: This novel technique is feasible and reproducible, with optimal clinical results.
DOI: 10.6084/m9.figshare.5696014.v1
title: Transtemporal amygdalohippocampectomy: a novel minimally-invasive technique with optimal clinical results and low cost

description: ABSTRACT Mesial temporal sclerosis creates a focal epileptic syndrome that usually requires surgical resection of mesial temporal structures. Objective: To describe a novel operative technique for treatment of temporal lobe epilepsy and its clinical results. Methods: Prospective case-series at a single institution, performed by a single surgeon, from 2006 to 2012. A total of 120 patients were submitted to minimally-invasive keyhole transtemporal amygdalohippocampectomy. Results: Of the patients, 55% were male, and 85% had a right-sided disease. The first 70 surgeries had a mean surgical time of 2.51 hours, and the last 50 surgeries had a mean surgical time of 1.62 hours. There was 3.3% morbidity, and 5% mild temporal muscle atrophy. There was no visual field impairment. On the Engel Outcome Scale at the two-year follow-up, 71% of the patients were Class I, 21% were Class II, and 6% were Class III. Conclusion: This novel technique is feasible and reproducible, with optimal clinical results.
DOI: 10.6084/m9.figshare.5696011
title: The relative frequency of common neuromuscular diagnoses in a reference center

description: ABSTRACT The diagnostic procedure in neuromuscular patients is complex. Knowledge of the relative frequency of neuromuscular diseases within the investigated population is important to allow the neurologist to perform the most appropriate diagnostic tests. Objective: To report the relative frequency of common neuromuscular diagnoses in a reference center. Methods: A 17-year chart review of patients with suspicion of myopathy. Results: Among 3,412 examinations, 1,603 (46.98%) yielded confirmatory results: 782 (48.78%) underwent molecular studies, and 821 (51.21%) had muscle biopsies. The most frequent diagnoses were: dystrophinopathy 460 (28.70%), mitochondriopathy 330 (20.59%), spinal muscular atrophy 158 (9.86%), limb girdle muscular dystrophy 157 (9.79%), Steinert myotonic dystrophy 138 (8.61%), facioscapulohumeral muscular dystrophy 99 (6.17%), and other diagnoses 261 (16.28%). Conclusion: Using the presently-available diagnostic techniques in this service, a specific limb girdle muscular dystrophy subtype diagnosis was reached in 61% of the patients. A neuromuscular-appropriate diagnosis is important for genetic counseling, rehabilitation orientation, and early treatment of respiratory and cardiac complications.
DOI: 10.6084/m9.figshare.5696011.v1
title: The relative frequency of common neuromuscular diagnoses in a reference center

description: ABSTRACT The diagnostic procedure in neuromuscular patients is complex. Knowledge of the relative frequency of neuromuscular diseases within the investigated population is important to allow the neurologist to perform the most appropriate diagnostic tests. Objective: To report the relative frequency of common neuromuscular diagnoses in a reference center. Methods: A 17-year chart review of patients with suspicion of myopathy. Results: Among 3,412 examinations, 1,603 (46.98%) yielded confirmatory results: 782 (48.78%) underwent molecular studies, and 821 (51.21%) had muscle biopsies. The most frequent diagnoses were: dystrophinopathy 460 (28.70%), mitochondriopathy 330 (20.59%), spinal muscular atrophy 158 (9.86%), limb girdle muscular dystrophy 157 (9.79%), Steinert myotonic dystrophy 138 (8.61%), facioscapulohumeral muscular dystrophy 99 (6.17%), and other diagnoses 261 (16.28%). Conclusion: Using the presently-available diagnostic techniques in this service, a specific limb girdle muscular dystrophy subtype diagnosis was reached in 61% of the patients. A neuromuscular-appropriate diagnosis is important for genetic counseling, rehabilitation orientation, and early treatment of respiratory and cardiac complications.
DOI: 10.6084/m9.figshare.5696005
title: Comparative genomics of pathogenic Leptospira interrogans serovar Canicola isolated from swine and human in Brazil

description: Leptospira interrogans serovar Canicola is one of the most important pathogenic serovars for the maintenance of urban leptospirosis. Even though it is considered highly adapted to dogs, serovar Canicola infection has already been described in other animals and even a few human cases. Here, we present the genomic characterisation of two Brazilian L. interrogans serovar Canicola strains isolated from slaughtered sows (L0-3 and L0-4) and their comparison with human strain Fiocruz LV133. It was observed that the porcine serovar Canicola strains present the genetic machinery to cause human infection and, therefore, represent a higher risk to public health. Both human and porcine serovar Canicola isolates also presented sequences with high identity to the Chinese serovar Canicola published plasmids pGui1 and pGui2. The plasmids identification in the Brazilian and Chinese serovar Canicola strains suggest that extra-chromosomal elements are one more feature of this serovar that was previously unnoticed.
DOI: 10.6084/m9.figshare.5696005.v1
title: Comparative genomics of pathogenic Leptospira interrogans serovar Canicola isolated from swine and human in Brazil

description: Leptospira interrogans serovar Canicola is one of the most important pathogenic serovars for the maintenance of urban leptospirosis. Even though it is considered highly adapted to dogs, serovar Canicola infection has already been described in other animals and even a few human cases. Here, we present the genomic characterisation of two Brazilian L. interrogans serovar Canicola strains isolated from slaughtered sows (L0-3 and L0-4) and their comparison with human strain Fiocruz LV133. It was observed that the porcine serovar Canicola strains present the genetic machinery to cause human infection and, therefore, represent a higher risk to public health. Both human and porcine serovar Canicola isolates also presented sequences with high identity to the Chinese serovar Canicola published plasmids pGui1 and pGui2. The plasmids identification in the Brazilian and Chinese serovar Canicola strains suggest that extra-chromosomal elements are one more feature of this serovar that was previously unnoticed.
DOI: 10.6084/m9.figshare.5695999
title: Response of bell pepper crop subjected to irrigation depths calculated by different methodologies

description: ABSTRACT Water must be supplied to a crop in the proper amount and in a timely manner. Vegetables require a good water availability in soil during their entire cycle. Thus, it is very important the implementation of an irrigation management and accurate estimation of water requirement. The objective of this work was to evaluate the effect of five irrigation depths estimated by the dual-Kc and single-Kc methodologies on the characteristics of growth, production and water use efficiency in the pepper crop. A randomized block design was adopted in a split plot arrangement. The effect of five irrigation depths (50, 75, 100, 125 and 150% of crop evapotranspiration - ETc) was evaluated in the plots, and the methodologies were evaluated in the subplots. It was evaluated the root dry matter, total fruit production, leaf temperature, number of aborted flowers and water use efficiency. The interaction between both effects was not significant for any of the variables. The effect of methodology was observed only on the number of aborted flowers. The effect of the irrigation depths was significant on all variables. The irrigation depths that lead to the best agronomic characteristics were superior to 100% of ETc. The ratio between the irrigation depths estimated by single-Kc and dual-Kc methodologies was 1.14. Single-Kc methodology and irrigation depth of 143% ETc were more suitable for the horticulturist. The most efficient irrigation depth in the use of water was 105% ETc.
DOI: 10.6084/m9.figshare.5695999.v1
title: Response of bell pepper crop subjected to irrigation depths calculated by different methodologies

description: ABSTRACT Water must be supplied to a crop in the proper amount and in a timely manner. Vegetables require a good water availability in soil during their entire cycle. Thus, it is very important the implementation of an irrigation management and accurate estimation of water requirement. The objective of this work was to evaluate the effect of five irrigation depths estimated by the dual-Kc and single-Kc methodologies on the characteristics of growth, production and water use efficiency in the pepper crop. A randomized block design was adopted in a split plot arrangement. The effect of five irrigation depths (50, 75, 100, 125 and 150% of crop evapotranspiration - ETc) was evaluated in the plots, and the methodologies were evaluated in the subplots. It was evaluated the root dry matter, total fruit production, leaf temperature, number of aborted flowers and water use efficiency. The interaction between both effects was not significant for any of the variables. The effect of methodology was observed only on the number of aborted flowers. The effect of the irrigation depths was significant on all variables. The irrigation depths that lead to the best agronomic characteristics were superior to 100% of ETc. The ratio between the irrigation depths estimated by single-Kc and dual-Kc methodologies was 1.14. Single-Kc methodology and irrigation depth of 143% ETc were more suitable for the horticulturist. The most efficient irrigation depth in the use of water was 105% ETc.
DOI: 10.6084/m9.figshare.5695996
title: The Multicampi School of Medical Sciences of the Federal University of Rio Grande do Norte, Brazil, in the context of the More Doctors Program: challenges and potentialities

description: This paper reports on the institutional and curricular experience of launching the Medical Course of the Multicampi School of Medical Sciences of the Federal University of Rio Grande do Norte (UFRN). This report is a way of documenting, monitoring and reflecting on the development of actions of expansion of seats and creation of new medical courses in federal universities, within the framework of the More Doctors Program. To that end, the teaching, research and extension actions already developed are critically described, as well as it is presented an overview of the course and the teaching-service-community integration, highlighting the achievements and challenges in the development of teaching, research and extension. Finally, we describe the difficulties inherent in the implantation of new courses outside urban centers in Brazil.
DOI: 10.6084/m9.figshare.5695993
title: Copper and zinc fractionation in biosolid cultivated with Pennisetum purpureum in different periods

description: ABSTRACT In order to reduce the effect of heavy metals on the biosolid, it is necessary to promote its phytoremediation. It is important to know the total content and chemical forms of these elements in the residue for analyzing its behavior and potential toxicity. Thus, the aim of this study was to evaluate the fractionation and behavior of Cu and Zn in biosolid cultivated with Pennisetum purpureum in different periods. The experiment was carried out using a randomized complete block design. The treatments, with five replicates, corresponded to Pennisetum purpureum cultivation in biosolid for 30, 60, 90, 120 and 150 days after planting. The total contents of Cu and Zn in the biosolid remained below the critical limits established by the CONAMA Resolution 357, and there was a reduction in these values with Pennisetum purpureum cultivation. Furthermore, the increment in the grass cultivation period caused intense reduction of Zn contents bound to organic matter, but there was an increase in soluble Zn and residual Zn. Additionally, there was an intense reduction in the content of Cu bound to sulfides. Therefore, for biosolid phytoremediation purposes, the grass should be cultivated for 150 days.