DOI: 10.5281/zenodo.13822504
title: Normalized Protein Expression Data for Alzheimer's, Parkinson's, and Stroke Studies

description: 该数据集来自英国生物样本库 (UKB) 和英国生物样本库制药蛋白质组学项目 (UKB-PPP),包含来自 54,219 名参与者的全面蛋白质组学和人口统计信息。该数据集包括 2,941 种蛋白质分析物的测量值,代表 2,923 种独特蛋白质。选择了一组 217 种神经学相关蛋白和 10 种人口统计学和生活方式协变量进行分析。该研究侧重于帕金森病、中风和阿尔茨海默病,使用 ICD-10 代码确定病例。该数据集是研究蛋白质组学生物标志物与神经系统疾病之间关系的宝贵资源,可用于复制和进一步研究。
description: File: ukbAD.csv

Description: 

Variables

•      Pro_0_191:ASGR1

•      Pro_0_290:BST1

•      Pro_0_711:CST5

•      Pro_0_1024:FCRL5

•      Pro_0_1431:INHBC

•      Pro_0_1840:NEFL

•      Pro_0_2189:PTK7

•      Pro_0_2201:PTPRN2

•      Pro_0_2353:SCARF2

•      Pro_0_2426:SFRP1

•      follow_AD: A binary variable indicating the incidence of Alzheimer's disease (AD) during the follow-up period.

1: Indicates a newly diagnosed AD case within the cohort.

0: Control group, individuals without an AD diagnosis.

•      PDday: The number of days from the start of follow-up to the diagnosis of Parkinson's disease or the end of the follow-up period for non-cases.

File: ukbpd.csv

Description: 

Variables

•      Pro_0_96:ALDH1A1

•      Pro_0_579:CLEC10A

•      Pro_0_896:EFNA1

•      Pro_0_1179:GLT8D2

•      Pro_0_1840:NEFL

•      Pro_0_2131:PRDX1

•      Pro_0_2229:RAB6B

•      Pro_0_2353:SCARF2

•      Pro_0_2459:SIRT5

•      Pro_0_2578:STC2

•      follow_PD: A binary variable indicating the incidence of Parkinson's disease (PD) during the follow-up period.

1: Indicates a newly diagnosed PD case within the cohort.

0: Control group, individuals without a PD diagnosis.

•      PDday: The number of days from the start of follow-up to the diagnosis of Parkinson's disease or the end of the follow-up period for non-cases.

File: ukbstroke.csv

Description: 

Variables

•      Pro_0_242:BCAN

•      Pro_0_721:CTRB1

•      Pro_0_1321:IDI2

•      Pro_0_1558:LAYN

•      Pro_0_1739:MMP9

•      Pro_0_1828:NDRG1

•      Pro_0_2407:SERPINB6

•      Pro_0_2409:SERPINB9

•      Pro_0_2459:SIRT5

•      Pro_0_2577:STC1

•      follow_stroke: A binary variable indicating the incidence of stroke during the follow-up period.

1: Indicates a newly diagnosed stroke case within the cohort.

0: Control group, individuals without a stroke diagnosis.

•      strokeday: The number of days from the start of follow-up to the diagnosis of stroke or the end of the follow-up period for non-cases.

 

 

 • Sex: A binary variable indicating the sex of the participant.

0: Female

1: Male

•    Townsend Deprivation : A numerical variable representing the Townsend Deprivation Index, a measure of socioeconomic status where higher values indicate greater levels of deprivation.

•      Annual Household Income: A categorical variable indicating the income level of the household.

1: Low income (less than £18,000/year)

2: Medium income (£18,000 to less than £52,000/year)

3: High income (equal to or greater than £52,000/year)

•      Education: A categorical variable representing the level of education attained.

1: General Education

2: Intermediate Education

3: Advanced Education

•      Smoking Status: A categorical variable indicating the participant’s smoking history.

0: Never smoked

1: Previous smoker

2: Current smoker

•      Alcohol Status: A categorical variable indicating the participant’s alcohol consumption history.

0: Never consumed alcohol

1: Previous alcohol consumer

2: Current alcohol consumer

•      Self-reported Ethnic Background: A binary variable indicating the participant’s self-identified ethnic background.

1: White

0: Non-White

•      Body Mass Index (BMI): A numerical variable representing the participant's BMI, calculated as weight in kilograms divided by height in meters squared (kg/m²).