cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.4585030
title: Supplementary Material for "The Effects on Adaptive Behaviour of Negatively Valenced Signals in Reinforcement Learning"

description: zip files with raw data from the 10 random initializations of the 4 best hyperparameter sets per condition and per activation function. Organized by function and per condition.<br><br>pdf file containing the pair-wise comparison of the three tested conditions against the baseline.<br><br>Link to the supplementary material of the original paper, includes matlab command and data set for learning:<br>https://figshare.com/s/becd4366e4ed38731353<br><b>References:<br></b>Navarro-Guerrero, N., Lowe, R., & Wermter, S. (2017). The Effects on Adaptive Behaviour of Negatively Valenced Signals in Reinforcement Learning. In Joint IEEE International Conference on Development and Learning and Epigenetic Robotics (ICDL-EPIROB) (pp. 148–155). Lisbon, Portugal: IEEE. https://doi.org/10.1109/DEVLRN.2017.8329800<br><br>Navarro-Guerrero, N., Lowe, R., & Wermter, S. (2017). Improving Robot Motor Learning with Negatively Valenced Reinforcement Signals. Frontiers in Neurorobotics, 11(10). https://doi.org/10.3389/fnbot.2017.00010<br><b>Contact:</b>For information please see the paper. For specific questions regarding the paper please contact Nicolás Navarro-Guerrero.
DOI: 10.6084/m9.figshare.4585042.v1
title: databases and R code (10112016).rar

description: <b>Objective:</b> To illustrate the ability of hierarchical Bayesian spatio-temporal models in capturing different geo-temporal structures in order to explain hospital risk variations using three different conditions: Percutaneous Coronary Intervention (PCI), Colectomy in Colorectal Cancer (CCC) and Chronic Obstructive Pulmonary Disease (COPD). <b>Research Design:</b> This is an observational population-based spatio-temporal study, from 2002 to 2013, with a two-level geographical structure, Autonomous Communities (AC) and Health Care Areas (HA). Setting: The Spanish National Health System, a quasi-federal structure with 17 regional governments (AC) with full responsibility in planning and financing, and 203 HA providing hospital and primary care to a defined population. <b>Methods:</b> A poisson-log normal mixed model in the Bayesian framework was fitted using the INLA efficient estimation procedure. Measures: The spatio-temporal hospitalization relative risks, the evolution of their variation, and the relative contribution (fraction of variation) of each of the model components (AC, HA, year and interaction AC-year).
DOI: 10.6084/m9.figshare.4585030.v1
title: Supplementary Material for "The Effects on Adaptive Behaviour of Negatively Valenced Signals in Reinforcement Learning"

description: zip files with raw data from the 10 random initializations of the 4 best hyperparameter sets per condition and per activation function. Organized by function and per condition.<br><br>pdf file containing the pair-wise comparison of the three tested conditions against the baseline.<br><br>Link to the supplementary material of the original paper, includes matlab command and data set for learning:<br>https://figshare.com/s/becd4366e4ed38731353<br><b>References:<br></b>Navarro-Guerrero, N., Lowe, R., & Wermter, S. (2017). The Effects on Adaptive Behaviour of Negatively Valenced Signals in Reinforcement Learning. In Joint IEEE International Conference on Development and Learning and Epigenetic Robotics (ICDL-EPIROB) (pp. 148–155). Lisbon, Portugal: IEEE. https://doi.org/10.1109/DEVLRN.2017.8329800<br><br>Navarro-Guerrero, N., Lowe, R., & Wermter, S. (2017). Improving Robot Motor Learning with Negatively Valenced Reinforcement Signals. Frontiers in Neurorobotics, 11(10). https://doi.org/10.3389/fnbot.2017.00010<br><b>Contact:</b>For information please see the paper. For specific questions regarding the paper please contact Nicolás Navarro-Guerrero.
DOI: 10.6084/m9.figshare.4585033
title: Zoneamento da umidade de equilíbrio mensal de painéis de madeira no Brasil

description: Banco de dados do artigo "Zoneamento da umidade de equilíbrio mensal de painéis de madeira no Brasil"<br>
DOI: 10.6084/m9.figshare.4584955
title: FMO2 HOP files

description: Input and output files for FMO2 HOP calculations for various basis sets.
DOI: 10.6084/m9.figshare.4585066.v1
title: MicroRNA expression profiles identify disease-specific alterations in systemic lupus erythematosus and Sjögren's syndrome

description: Supplementary materials for the work entitled "MicroRNA expression profiles identify disease-specific alterations in systemic lupus erythematosus and Sjögren's syndrome". All data available in Excel format.
DOI: 10.6084/m9.figshare.4585033.v2
title: Zoneamento da umidade de equilíbrio mensal de painéis de madeira no Brasil

description: Banco de dados do artigo "Zoneamento da umidade de equilíbrio mensal de painéis de madeira no Brasil"<br>
DOI: 10.6084/m9.figshare.4584955.v1
title: FMO2 HOP files

description: Input and output files for FMO2 HOP calculations for various basis sets.
DOI: 10.6084/m9.figshare.4585033.v1
title: Zoneamento espaço-temporal da umidade de equilíbrio de painéis de madeira no Brasil

description: Banco de dados do artigo "Zoneamento espaço-temporal da umidade de equilíbrio de painéis de madeira no Brasil"<br>
DOI: 10.6084/m9.figshare.4585066.v3
title: MicroRNA expression profiles identify disease-specific alterations in systemic lupus erythematosus and Sjögren's syndrome

description: Supplementary materials for the work entitled "MicroRNA expression profiles identify disease-specific alterations in systemic lupus erythematosus and Sjögren's syndrome". All data available in Excel format.
DOI: 10.6084/m9.figshare.4584949
title: FMO2 AFO files

description: Input files for FMO2 AFO calculations for various basis sets.
DOI: 10.6084/m9.figshare.4585066.v2
title: MicroRNA expression profiles identify disease-specific alterations in systemic lupus erythematosus and Sjögren's syndrome

description: Supplementary materials for the work entitled "MicroRNA expression profiles identify disease-specific alterations in systemic lupus erythematosus and Sjögren's syndrome". All data available in Excel format.
DOI: 10.6084/m9.figshare.4584949.v1
title: FMO2 AFO files

description: Input files for FMO2 AFO calculations for various basis sets.
DOI: 10.6084/m9.figshare.4584874
title: <i>In situ</i> LA-ICP-MS <sup>40</sup>Ar/<sup>39</sup>Ar isotopic age determination results. Using palaeomagnetic and isotopic data to investigate late to post-Caledonian tectonothermal processes within the Western Terrane of Svalbard

description: Supplementary data 4 - <i>in situ</i> LA-ICP-MS <sup>40</sup>Ar/<sup>39</sup>Ar isotopic age determination results
DOI: 10.6084/m9.figshare.4584829
title: Clinical response to golimumab in rheumatoid arthritis patients who were receiving etanercept or adalimumab: results of a multicenter active treatment study

description: <b>Objective:</b> Evaluate the efficacy and safety of subcutaneous (SC) golimumab + methotrexate (MTX) in patients with active rheumatoid arthritis (RA) despite etanercept + MTX or adalimumab + MTX therapy and evaluate whether intravenous (IV) golimumab could rescue patients who were nonresponders to SC golimumab. <b>Methods:</b> In this multicenter, assessor-blinded, active-switch study of patients with RA (<i>n</i> = 433) with inadequate response to etanercept or adalimumab + MTX, patients continued MTX and received open-label SC golimumab 50 mg every 4 weeks through week 12. DAS28-ESR good responders at week 16 continued open-label SC golimumab through week 52 (Group 1); nonresponders were randomized to double-blind golimumab SC 50 mg (Group 2-SC) or IV 2 mg/kg (Group 2-IV). Week 14 ACR20 was the primary endpoint; assessments continued through week 52 and for patients in the voluntary long-term extension through week 76. A major secondary endpoint was the proportions of patients with ACR20 response at week 52 relative to week 16 in Group 2-SC and Group 2-IV. <b>Results:</b> At week 14, 34.9% (<i>p</i> n = 75) achieved an ACR20 (62.7%). In Groups 2-SC (<i>n</i> = 91) and 2-IV (<i>n</i> = 184), 13.2% and 9.2% had an ACR20 at week 52 relative to week 16, with no significant difference between the randomized groups; 42.9% and 47.8% achieved DAS28-ESR response relative to week 0. Through week 16, 4.6% of patients had a serious adverse event. No differences in the rates or types of adverse events were observed between SC and IV golimumab from weeks 16 to 52. The trial limitations included a higher than expected discontinuation rate as a result of a programming error. <b>Conclusion:</b> SC golimumab + MTX significantly suppressed disease activity in RA patients with inadequate response to etanercept and/or adalimumab + MTX. Patients randomized to Groups 2-SC and 2-IV had lower response rates than Group 1, with no difference between SC or IV mode of administration. The safety profile with IV golimumab was comparable to that established with SC golimumab. <b>Trial registration:</b> NCT01004432, EudraCT 2009-010582-23.
DOI: 10.6084/m9.figshare.4584829.v1
title: Clinical response to golimumab in rheumatoid arthritis patients who were receiving etanercept or adalimumab: results of a multicenter active treatment study

description: <b>Objective:</b> Evaluate the efficacy and safety of subcutaneous (SC) golimumab + methotrexate (MTX) in patients with active rheumatoid arthritis (RA) despite etanercept + MTX or adalimumab + MTX therapy and evaluate whether intravenous (IV) golimumab could rescue patients who were nonresponders to SC golimumab. <b>Methods:</b> In this multicenter, assessor-blinded, active-switch study of patients with RA (<i>n</i> = 433) with inadequate response to etanercept or adalimumab + MTX, patients continued MTX and received open-label SC golimumab 50 mg every 4 weeks through week 12. DAS28-ESR good responders at week 16 continued open-label SC golimumab through week 52 (Group 1); nonresponders were randomized to double-blind golimumab SC 50 mg (Group 2-SC) or IV 2 mg/kg (Group 2-IV). Week 14 ACR20 was the primary endpoint; assessments continued through week 52 and for patients in the voluntary long-term extension through week 76. A major secondary endpoint was the proportions of patients with ACR20 response at week 52 relative to week 16 in Group 2-SC and Group 2-IV. <b>Results:</b> At week 14, 34.9% (<i>p</i> n = 75) achieved an ACR20 (62.7%). In Groups 2-SC (<i>n</i> = 91) and 2-IV (<i>n</i> = 184), 13.2% and 9.2% had an ACR20 at week 52 relative to week 16, with no significant difference between the randomized groups; 42.9% and 47.8% achieved DAS28-ESR response relative to week 0. Through week 16, 4.6% of patients had a serious adverse event. No differences in the rates or types of adverse events were observed between SC and IV golimumab from weeks 16 to 52. The trial limitations included a higher than expected discontinuation rate as a result of a programming error. <b>Conclusion:</b> SC golimumab + MTX significantly suppressed disease activity in RA patients with inadequate response to etanercept and/or adalimumab + MTX. Patients randomized to Groups 2-SC and 2-IV had lower response rates than Group 1, with no difference between SC or IV mode of administration. The safety profile with IV golimumab was comparable to that established with SC golimumab. <b>Trial registration:</b> NCT01004432, EudraCT 2009-010582-23.
DOI: 10.6084/m9.figshare.4584772
title: Partial modified ECG-ViEW II dataset

description: Partial modified ECG-ViEW II dataset
DOI: 10.6084/m9.figshare.4584772.v1
title: person.csv

description: ECG-ViEW II sample dataset person table
DOI: 10.6084/m9.figshare.4584772.v2
title: ECG-ViEW II sample dataset

description: ECG-ViEW II sample dataset
DOI: 10.6084/m9.figshare.4584772.v3
title: ECG-ViEW II sample dataset

description: ECG-ViEW II sample dataset
DOI: 10.6084/m9.figshare.4584772.v4
title: partial modified ECG-ViEW II dataset

description: partial modified ECG-ViEW II dataset
DOI: 10.6084/m9.figshare.4584304
title: Data and integrated population models for Ecological Applications manuscript "Assessing the importance of demographic parameters using Bayesian integrated population modeling.

description: Data and JAGS code to run base and sensitivity integrated population models using program R. Please see attached Metadata files for specific details.
DOI: 10.6084/m9.figshare.4584274
title: Helicobacter pylori infection and low dietary iron alter behavior, induce iron deficiency anemia, and modulate hippocampal gene expression in female C57BL/6 mice

description: See abstract
DOI: 10.6084/m9.figshare.4584274.v1
title: Helicobacter pylori infection and low dietary iron alter behavior, induce iron deficiency anemia, and modulate hippocampal gene expression in female C57BL/6 mice

description: See abstract
DOI: 10.6084/m9.figshare.4584268
title: FEM1 proteins are ancient regulators of SLBP degradation

description: FEM1A, FEM1B, and FEM1C are evolutionarily-conserved VHL-box proteins, the substrate recognition subunits of CUL2-RING E3 ubiquitin ligase complexes. Here, we report that FEM1 proteins are ancient regulators of Stem-Loop Binding Protein (SLBP), a conserved protein that interacts with the stem loop structure located in the 3′ end of canonical histone mRNAs and functions in mRNA cleavage, translation and degradation. SLBP levels are highest during S-phase coinciding with histone synthesis. The ubiquitin ligase complex SCF<sup>cyclin F</sup> targets SLBP for degradation in G2 phase; however, the regulation of SLBP during other stages of the cell cycle is poorly understood. We provide evidence that FEM1A, FEM1B, and FEM1C interact with and mediate the degradation of SLBP. Cyclin F, FEM1A, FEM1B and FEM1C all interact with a region in SLBP's N-terminus using distinct degrons. An SLBP mutant that is unable to interact with all 4 ligases is expressed at higher levels than wild type SLBP and does not oscillate during the cell cycle. We demonstrate that orthologues of SLBP and FEM1 proteins interact in <i>C. elegans</i> and <i>D. melanogaster</i>, suggesting that the pathway is evolutionarily conserved. Furthermore, we show that FEM1 depletion in <i>C. elegans</i> results in the upregulation of SLBP ortholog CDL-1 in oocytes. Notably, cyclin F is absent in flies and worms, suggesting that FEM1 proteins play an important role in SLBP targeting in lower eukaryotes.
DOI: 10.6084/m9.figshare.4584262
title: Myogenic potential of human alveolar mucosa derived cells

description: Difficulties related to the obtainment of stem/progenitor cells from skeletal muscle tissue make the search for new sources of myogenic cells highly relevant. Alveolar mucosa might be considered as a perspective candidate due to availability and high proliferative capacity of its cells. Human alveolar mucosa cells (AMC) were obtained from gingival biopsy samples collected from 10 healthy donors and cultured up to 10 passages. AMC matched the generally accepted multipotent mesenchymal stromal cells criteria and possess population doubling time, caryotype and immunophenotype stability during long-term cultivation. The single myogenic induction of primary cell cultures resulted in differentiation of AMC into multinucleated myotubes. The myogenic differentiation was associated with expression of skeletal muscle markers: skeletal myosin, skeletal actin, myogenin and MyoD1. Efficiency of myogenic differentiation in AMC cultures was similar to that in skeletal muscle cells. Furthermore, some of differentiated myotubes exhibited contractions <i>in vitro</i>. Our data confirms the sufficiently high myogenic potential and proliferative capacity of AMC and their ability to maintain <i>in vitro</i> proliferation-competent myogenic precursor cells regardless of the passage number.
DOI: 10.6084/m9.figshare.4584265
title: A comparison of radiation-induced mitochondrial damage between neural progenitor stem cells and differentiated cells

description: Mitochondria play a key role in maintaining cellular homeostasis during stress responses, and mitochondrial dysfunction contributes to carcinogenesis, aging, and neurologic disease. We here investigated ionizing radiation (IR)-induced mitochondrial damage in human neural progenitor stem cells (NSCs), their differentiated counterparts and human normal fibroblasts. Long-term fractionated radiation (FR) with low doses of X-rays for 31 d enhanced mitochondrial activity as evident by elevated mitochondrial membrane potential (ΔΨm) and mitochondrial complex IV (cytochrome c oxidase) activity to fill the energy demands for the chronic DNA damage response in differentiated cells. Subsequent reduction of the antioxidant glutathione via continuous activation of mitochondrial oxidative phosphorylation caused oxidative stress and genomic instability in differentiated cells exposed to long-term FR. In contrast, long-term FR had no effect on the mitochondrial activity in NSCs. This cell type showed efficient DNA repair, no mitochondrial damage, and resistance to long-term FR. After high doses of acute single radiation (SR) (&gt; 5 Gy), cell cycle arrest at the G2 phase was observed in NSCs and human fibroblasts. Under this condition, increase in mitochondria mass, mitochondrial DNA, and intracellular reactive oxygen species (ROS) levels were observed in the absence of enhanced mitochondrial activity. Consequently, cellular senescence was induced by high doses of SR in differentiated cells. In conclusion, we demonstrated that mitochondrial radiation responses differ according to the extent of DNA damage, duration of radiation exposure, and cell differentiation.
DOI: 10.6084/m9.figshare.4584262.v1
title: Myogenic potential of human alveolar mucosa derived cells

description: Difficulties related to the obtainment of stem/progenitor cells from skeletal muscle tissue make the search for new sources of myogenic cells highly relevant. Alveolar mucosa might be considered as a perspective candidate due to availability and high proliferative capacity of its cells. Human alveolar mucosa cells (AMC) were obtained from gingival biopsy samples collected from 10 healthy donors and cultured up to 10 passages. AMC matched the generally accepted multipotent mesenchymal stromal cells criteria and possess population doubling time, caryotype and immunophenotype stability during long-term cultivation. The single myogenic induction of primary cell cultures resulted in differentiation of AMC into multinucleated myotubes. The myogenic differentiation was associated with expression of skeletal muscle markers: skeletal myosin, skeletal actin, myogenin and MyoD1. Efficiency of myogenic differentiation in AMC cultures was similar to that in skeletal muscle cells. Furthermore, some of differentiated myotubes exhibited contractions <i>in vitro</i>. Our data confirms the sufficiently high myogenic potential and proliferative capacity of AMC and their ability to maintain <i>in vitro</i> proliferation-competent myogenic precursor cells regardless of the passage number.
DOI: 10.6084/m9.figshare.4584268.v1
title: FEM1 proteins are ancient regulators of SLBP degradation

description: FEM1A, FEM1B, and FEM1C are evolutionarily-conserved VHL-box proteins, the substrate recognition subunits of CUL2-RING E3 ubiquitin ligase complexes. Here, we report that FEM1 proteins are ancient regulators of Stem-Loop Binding Protein (SLBP), a conserved protein that interacts with the stem loop structure located in the 3′ end of canonical histone mRNAs and functions in mRNA cleavage, translation and degradation. SLBP levels are highest during S-phase coinciding with histone synthesis. The ubiquitin ligase complex SCF<sup>cyclin F</sup> targets SLBP for degradation in G2 phase; however, the regulation of SLBP during other stages of the cell cycle is poorly understood. We provide evidence that FEM1A, FEM1B, and FEM1C interact with and mediate the degradation of SLBP. Cyclin F, FEM1A, FEM1B and FEM1C all interact with a region in SLBP's N-terminus using distinct degrons. An SLBP mutant that is unable to interact with all 4 ligases is expressed at higher levels than wild type SLBP and does not oscillate during the cell cycle. We demonstrate that orthologues of SLBP and FEM1 proteins interact in <i>C. elegans</i> and <i>D. melanogaster</i>, suggesting that the pathway is evolutionarily conserved. Furthermore, we show that FEM1 depletion in <i>C. elegans</i> results in the upregulation of SLBP ortholog CDL-1 in oocytes. Notably, cyclin F is absent in flies and worms, suggesting that FEM1 proteins play an important role in SLBP targeting in lower eukaryotes.
DOI: 10.6084/m9.figshare.4584271
title: Midbody localization of vinexin recruits rhotekin to facilitate cytokinetic abscission

description: Vinexin is a SH3 domain-containing adaptor protein that has diverse roles in cell adhesion, signal transduction, gene regulation and stress granule assembly. In this study, we found that vinexin localizes at the midbody during cell division and facilitates cytokinesis. Knockdown of vinexin in HeLa cells delayed the mitotic cell cycle progression and increased the time of cell abscission and the failure to resolve the cytoplasmic bridge. Midbody-localized vinexin is essential for recruiting rhotekin to this structure for cytokinesis because overexpression of a vinexin mutant without a rhotekin-binding motif or knockdown of rhotekin also impaired cytokinetic abscission and increased the number of cells arrested at the midbody stage. Aberrant expression of vinexin and rhotekin in various cancers has been implicated to promote metastasis because of their functions in cell adhesion and signaling. Our findings reveal a novel role of vinexin and rhotekin in cytokinetic abscission and provide another perspective of how both molecules may affect oncogenic transformation via this fundamental cell cycle process.
DOI: 10.6084/m9.figshare.4584265.v1
title: A comparison of radiation-induced mitochondrial damage between neural progenitor stem cells and differentiated cells

description: Mitochondria play a key role in maintaining cellular homeostasis during stress responses, and mitochondrial dysfunction contributes to carcinogenesis, aging, and neurologic disease. We here investigated ionizing radiation (IR)-induced mitochondrial damage in human neural progenitor stem cells (NSCs), their differentiated counterparts and human normal fibroblasts. Long-term fractionated radiation (FR) with low doses of X-rays for 31 d enhanced mitochondrial activity as evident by elevated mitochondrial membrane potential (ΔΨm) and mitochondrial complex IV (cytochrome c oxidase) activity to fill the energy demands for the chronic DNA damage response in differentiated cells. Subsequent reduction of the antioxidant glutathione via continuous activation of mitochondrial oxidative phosphorylation caused oxidative stress and genomic instability in differentiated cells exposed to long-term FR. In contrast, long-term FR had no effect on the mitochondrial activity in NSCs. This cell type showed efficient DNA repair, no mitochondrial damage, and resistance to long-term FR. After high doses of acute single radiation (SR) (&gt; 5 Gy), cell cycle arrest at the G2 phase was observed in NSCs and human fibroblasts. Under this condition, increase in mitochondria mass, mitochondrial DNA, and intracellular reactive oxygen species (ROS) levels were observed in the absence of enhanced mitochondrial activity. Consequently, cellular senescence was induced by high doses of SR in differentiated cells. In conclusion, we demonstrated that mitochondrial radiation responses differ according to the extent of DNA damage, duration of radiation exposure, and cell differentiation.