cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.8092460
title: Automated cortical auditory evoked potentials threshold estimation in neonates

description: Abstract Introduction: The evaluation of cortical auditory evoked potential has been the focus of scientific studies in infants. Some authors have reported that automated response detection is effective in exploring these potentials in infants, but few have reported their efficacy in the search for thresholds. Objective: To analyze the latency, amplitude and thresholds of cortical auditory evoked potential using an automatic response detection device in a neonatal population. Methods: This is a cross-sectional, observational study. Cortical auditory evoked potentials were recorded in response to pure-tone stimuli of the frequencies 500, 1000, 2000 and 4000 Hz presented in an intensity range between 0 and 80 dB HL using a single channel recording. P1 was performed in an exclusively automated fashion, using Hotelling's T2 statistical test. The latency and amplitude were obtained manually by three examiners. The study comprised 39 neonates up to 28 days old of both sexes with presence of otoacoustic emissions and no risk factors for hearing loss. Results: With the protocol used, cortical auditory evoked potential responses were detected in all subjects at high intensity and thresholds. The mean thresholds were 24.8 ± 10.4 dB NA, 25 ± 9.0 dB NA, 28 ± 7.8 dB NA and 29.4 ± 6.6 dB HL for 500, 1000, 2000 and 4000 Hz, respectively. Conclusion: Reliable responses were obtained in the assessment of cortical auditory potentials in the neonates assessed with a device for automatic response detection.
DOI: 10.6084/m9.figshare.8092463.v1
title: Resistance to temephos and deltamethrin in Aedes aegypti from Brazil between 1985 and 2017

description: BACKGROUND Aedes aegypti populations in Brazil have been subjected to insecticide selection pressures with variable levels and sources since 1967. Therefore, the Brazilian Ministry of Health (MoH) coordinated the activities of an Ae. aegypti insecticide resistance monitoring network (MoReNAa) from 1999 to 2012. OBJECTIVES The objective of this study was to consolidate all information available from between 1985 and 2017 regarding the resistance status and mechanisms of Brazilian Ae. aegypti populations against the main insecticide compounds used at the national level, including the larvicide temephos (an organophosphate) and the adulticide deltamethrin (a pyrethroid). METHODS Data were gathered from two sources: a bibliographic review of studies published from 1985 to 2017, and unpublished data produced by our team within the MoReNAa between 1998 and 2012. A total of 146 municipalities were included, many of which were evaluated several times, totalling 457 evaluations for temephos and 274 for deltamethrin. Insecticide resistance data from the five Brazilian regions were examined separately using annual records of both the MoH supply of insecticides to each state and the dengue incidence in each evaluated municipality. FINDINGS Ae. aegypti resistance to temephos and deltamethrin, the main larvicide and adulticide, respectively, employed against mosquitoes in Brazil for a long time, was found to be widespread in the country, although with some regional variations. Comparisons between metabolic and target-site resistance mechanisms showed that one or another of these was the main component of pesticide resistance in each studied population. MAIN CONCLUSIONS (i) A robust dataset on the assessments of the insecticide resistance of Brazilian Ae. aegypti populations performed since 1985 was made available through our study. (ii) Our findings call into question the efficacy of chemical control as the sole methodology of vector control. (iii) It is necessary to ensure that sustainable insecticide resistance monitoring is maintained as a key component of integrated vector management. (iv) Consideration of additional parameters, beyond the supply of insecticides distributed by the MoH or the diverse local dynamics of dengue incidence, is necessary to find consistent correlations with heterogeneous vector resistance profiles.
DOI: 10.6084/m9.figshare.8092451
title: Chemical composition and lipoxygenase activity of soybean (Glycine max L. Merrill.) genotypes, specific for human consumption, with different tegument colours

description: Abstract Recently, in Brazil, coloured-tegument soybean cultivars have been developed, such as those with brown and black teguments. Soybeans with black teguments have been widely used for decades due to their health benefits and their use in oriental folk medicine as a result of the presence of phytochemicals. They have been recognized as health-promoting functional food ingredients due to their antioxidant activity, and are also known to have anti-cancer, hypoglycaemic and anti-inflammatory effects and have been used in the treatment of various circulatory disorders. This study aimed to determine the proximate composition, fatty acid levels and lipoxygenase activity of soybean lineages with different tegument colours intended for human consumption. The lineage MGBR10-16601 which has a yellow tegument, presented the highest protein and lowest fat contents, with values of 37.6 g 100 g-1 and 18.3 g 100 g-1, respectively. The lineage MGBR10-16201, which also has a yellow tegument, was identified as free of lipoxygenase isoenzymes. The unsaturated fatty acid levels ranged from 18.48 to 31.37 mg g-1 and from 47.36 to 58.31 mg g-1 for oleic and linoleic acids, respectively. The lineage BRN07-50543, which has a black tegument, presented high total isoflavone levels (546 mg 100 g-1), with an oleic acid level above and linoleic acid level below the standards established by the Codex Alimentarius for soybean oil, with values of 31.37 mg g-1 and 47.36 mg g-1, respectively. The cultivar BRSMG 790A, which has a yellow tegument, presented the lowest isoflavone level (171.4 mg 100 g-1). All the genetic materials examined presented crude protein, fat, dietary fibre and ash levels within the commercial parameters established for soybeans.
DOI: 10.6084/m9.figshare.8092454
title: Association Between Chocolate Consumption and Severity of First Infarction

description: Abstract Background: Cardiovascular diseases, such as acute myocardial infarction, are the main causes of death in the world. The flavonoids present in chocolate can have benefits for people who have risk factors to the development of cardiovascular diseases and have a coadjuvant effect on known therapies. Objective: To analyze the association between chocolate consumption, severity of coronary lesions, risk factors and severity of the first infarction in patients attended at the Cardiology Institute of Santa Catarina and other hospitals in the State of Santa Catarina. Methods: Subanalysis of the Catarina Heart Study cohort, evaluated 350 patients with first myocardial infarction. We evaluated clinical, echocardiographic, hemodynamic laboratorial variables. We used chi square test to evaluate qualitative variables, t student test in the case of parametric variables and U Mann Whitney test in non-parametric variables. We considered significant p &lt; 0,05. Results: Lower prevalence of hypertension (43.2% % vs. 62.3% p = 0.003), diabetes mellitus (13.5% vs. 25.7%, p = 0.027) and smoking (24.3% vs. 37.7%, p = 0.032) among those who consume chocolate. Higher use of alcohol (40.5% vs. 26.4%, p = 0.018) and drugs (9.5% vs. 3.3%, p = 0.023) among those who consumed chocolate. Among the patients who consumed chocolate, there was a negative correlation between amount consumed and Syntax (r = -0.296, p = 0.019). Conclusion: There was association between chocolate consumption and lower prevalence of hypertension, diabetes and smoking. There was no association between amount of chocolate consumed and post-infarction ventricular function and TIMI frame count. Higher prevalence of alcohol and drug use among those who consume chocolate. Negative correlation between Syntax and the amount of chocolate consumed.
DOI: 10.6084/m9.figshare.8092454.v1
title: Association Between Chocolate Consumption and Severity of First Infarction

description: Abstract Background: Cardiovascular diseases, such as acute myocardial infarction, are the main causes of death in the world. The flavonoids present in chocolate can have benefits for people who have risk factors to the development of cardiovascular diseases and have a coadjuvant effect on known therapies. Objective: To analyze the association between chocolate consumption, severity of coronary lesions, risk factors and severity of the first infarction in patients attended at the Cardiology Institute of Santa Catarina and other hospitals in the State of Santa Catarina. Methods: Subanalysis of the Catarina Heart Study cohort, evaluated 350 patients with first myocardial infarction. We evaluated clinical, echocardiographic, hemodynamic laboratorial variables. We used chi square test to evaluate qualitative variables, t student test in the case of parametric variables and U Mann Whitney test in non-parametric variables. We considered significant p &lt; 0,05. Results: Lower prevalence of hypertension (43.2% % vs. 62.3% p = 0.003), diabetes mellitus (13.5% vs. 25.7%, p = 0.027) and smoking (24.3% vs. 37.7%, p = 0.032) among those who consume chocolate. Higher use of alcohol (40.5% vs. 26.4%, p = 0.018) and drugs (9.5% vs. 3.3%, p = 0.023) among those who consumed chocolate. Among the patients who consumed chocolate, there was a negative correlation between amount consumed and Syntax (r = -0.296, p = 0.019). Conclusion: There was association between chocolate consumption and lower prevalence of hypertension, diabetes and smoking. There was no association between amount of chocolate consumed and post-infarction ventricular function and TIMI frame count. Higher prevalence of alcohol and drug use among those who consume chocolate. Negative correlation between Syntax and the amount of chocolate consumed.
DOI: 10.6084/m9.figshare.8092460.v1
title: Automated cortical auditory evoked potentials threshold estimation in neonates

description: Abstract Introduction: The evaluation of cortical auditory evoked potential has been the focus of scientific studies in infants. Some authors have reported that automated response detection is effective in exploring these potentials in infants, but few have reported their efficacy in the search for thresholds. Objective: To analyze the latency, amplitude and thresholds of cortical auditory evoked potential using an automatic response detection device in a neonatal population. Methods: This is a cross-sectional, observational study. Cortical auditory evoked potentials were recorded in response to pure-tone stimuli of the frequencies 500, 1000, 2000 and 4000 Hz presented in an intensity range between 0 and 80 dB HL using a single channel recording. P1 was performed in an exclusively automated fashion, using Hotelling's T2 statistical test. The latency and amplitude were obtained manually by three examiners. The study comprised 39 neonates up to 28 days old of both sexes with presence of otoacoustic emissions and no risk factors for hearing loss. Results: With the protocol used, cortical auditory evoked potential responses were detected in all subjects at high intensity and thresholds. The mean thresholds were 24.8 ± 10.4 dB NA, 25 ± 9.0 dB NA, 28 ± 7.8 dB NA and 29.4 ± 6.6 dB HL for 500, 1000, 2000 and 4000 Hz, respectively. Conclusion: Reliable responses were obtained in the assessment of cortical auditory potentials in the neonates assessed with a device for automatic response detection.
DOI: 10.6084/m9.figshare.8092445
title: Graduate students’ perceptions of changes in climate and their related impacts: a case study in the Federal District

description: Abstract Anthropogenic activities have been altering the environment and contributing to climate change (CC). Thus, the understanding of how new perceptions could result in pro-environmental actions and the role of environmental education in this equation are both necessary. A total of 1526 questionnaires were administered to graduate students, aiming to understand students’ perceptions of climate change in different economic sectors and social strata, as well as other personal beliefs. The need for a more intense approach regarding environmental knowledge, with the insertion of this theme at all educational level in unison with law 9795/99 was observed. Moreover, the limited knowledge about the links among information, perception and actions to cope with climate change indicates the need for more research that can explore how better environmental and climatic education can help in the development of perceptions and actions in favour of adaptation and mitigation public policies.
DOI: 10.6084/m9.figshare.8092448
title: CLINICAL CARE AND OVERMEDICALIZATION IN PRIMARY HEALTH CARE

description: Abstract This essay analyzes the overmedicalization (unnecessary and unwanted medicalization) generated in the medical care to the ill in primary health care, and discusses how it happens and how to avoid it. The analysis combines three sets of conceptions/knowledge: conceptions of illness (dynamic/ontological); conceptions of causation (ascending/multidirectional); key conceptual and structuring ideas about medical knowledge (anatomopathological, physiopatological, semiological, epidemiological). Overmedicalization is due to the cognitive movements of the professionals in the development of diagnoses and therapies. It originates from the ontological conception of illness with ascending causation (causal flow that goes from the simplest material elements to more complex levels and dimensions), in combination with the overestimation of the anatomopathological key idea, which generates excessive diagnostic and pharmacotherapeutic interventions. In order to avoid overmedicalization, we propose the virtuous association of the dynamic conception of illness, with multidirectional causation and balanced used of the key conceptual ideas of the illnesses. This facilitates: a qualified listening; the contextualization of the cases; a more rigorous use of complementary exams; the recognition of the limits of the biomedical diagnoses; the overcoming of the metonymical reasoning (which disregards anything that is not scientifically-established knowledge); an expansion of the interpretation that goes beyond the 'illnesses' and treatments that go beyond drugs/surgeries, exploring the knowledge of the users and professionals and the return of the problems to autonomous supported management.
DOI: 10.6084/m9.figshare.8092457.v1
title: The Evolution of Pneumatic Foramina in Pterosaur Vertebrae

description: Abstract: Pterosaurs possess skeletal pneumatization, which can be assessed externally through the observation of pneumatic foramina. These foramina vary in position, shape, and number among taxa. Here we propose new characters referring to the position and number of pneumatic foramina present in cervical and dorsal vertebrae of pterosaurs. A cladistic analysis was performed after first-hand study of material in collections and using data from the literature in order to test these new characters for homology, and they were subsequently mapped in a strict consensus tree. The analysis resulted in nine equally parsimonious trees with 215 steps each. The strict consensus tree obtained does not present significant differences in relation to trees obtained in previous studies. The mapping performed identified that most pneumatic foramina evolved independently in several lineages, and only two of the eight added characters appeared once in the evolution of pterosaurs. In general, pneumatic foramina were more common in the Dsungaripteroidea, however, the flattened preservation of non-pterodactyloids and in the Archaeopterodactyloidea often precludes their visualization, and therefore the presence of vertebral pneumatization may be broaden with the discovery of new, better preserved specimens.
DOI: 10.6084/m9.figshare.8092439
title: Allometric models to estimate tree height in northern Amazonian ecotone forests

description: ABSTRACT Allometric models defining the relationship between stem diameter and total tree height in the Amazon basin are important because they refine the estimates of tree carbon stocks and flow in the region. This study tests different allometric models to estimate the total tree height from the stem diameter in an ecotone zone between ombrophilous and seasonal forests in the Brazilian state of Roraima, in northern Amazonia. Stem diameter and total height were measured directly in 65 recently fallen trees (live or dead). Linear and nonlinear regressions were tested to represent the D:H relation in this specific ecotone zone. Criteria for model selection were the standard error of the estimate (Syx) and the adjusted coefficient of determination (R²adj), complemented by the Akaike Information Criterion (AIC). Analysis of residuals of the most parsimonious nonlinear models showed a tendency to overestimate the total tree height for trees in the 20-40 cm diameter range. Application of our best fitted model (Michaelis-Menten) indicated that previously published general equations for the tropics that use diameter as the independent variable can either overestimate tree height in the study area by 10-29% (Weibull models) or underestimate it by 8% (climate-based models). We concluded that our site-specific model can be used in the ecotone forests studied in Roraima because it realistically reflects the local biometric relationships between stem diameter and total tree height. Studies need to be expanded in peripheral areas of northern Amazonia in order to reduce uncertainties in biomass and carbon estimates that use the tree height as a variable in general models.
DOI: 10.6084/m9.figshare.8092442
title: Genetic Population Structure and Allele Surfing During Range Expansion in Dynamic Habitats

description: Abstract: Expanding populations may loss genetic diversity because sequential founder events throughout a wave of demographic expansion may cause “allele surfing”, as the alleles of founder individuals may propagate rapidly through space. The spatial components of allele surfing have been studied by geneticists, but have never been investigate on dynamic and shifting habitats. Here we used an individual-based-model (IBM) to study how interactions between different habitat restoration scenarios and biological characteristics (dispersal capacity) affect the spatial patterns of the genetic structure of a population during demographic expansion. We found that both habitat dynamics and dispersal capacity, as well as their interaction, were the drivers of emergent pattern of genetic diversity and allele surfing. Specifically, allele surfing is more common when a species with low dispersal capacity colonizes a large geographic area with slow restoration (low carrying capacity). Despite this, we showed that allele surfing can be reduced, or even avoided, by dispersal management through suitable habitat restoration. Thus, investigating how colonization generates a spatial variation in genetic diversity, and which parameters control the emergent genetic pattern, are essential steps to planning assisted gene flow, which is fundamental for an effective planning of habitat restoration.
DOI: 10.6084/m9.figshare.8092445.v1
title: Graduate students’ perceptions of changes in climate and their related impacts: a case study in the Federal District

description: Abstract Anthropogenic activities have been altering the environment and contributing to climate change (CC). Thus, the understanding of how new perceptions could result in pro-environmental actions and the role of environmental education in this equation are both necessary. A total of 1526 questionnaires were administered to graduate students, aiming to understand students’ perceptions of climate change in different economic sectors and social strata, as well as other personal beliefs. The need for a more intense approach regarding environmental knowledge, with the insertion of this theme at all educational level in unison with law 9795/99 was observed. Moreover, the limited knowledge about the links among information, perception and actions to cope with climate change indicates the need for more research that can explore how better environmental and climatic education can help in the development of perceptions and actions in favour of adaptation and mitigation public policies.
DOI: 10.6084/m9.figshare.8092439.v1
title: Allometric models to estimate tree height in northern Amazonian ecotone forests

description: ABSTRACT Allometric models defining the relationship between stem diameter and total tree height in the Amazon basin are important because they refine the estimates of tree carbon stocks and flow in the region. This study tests different allometric models to estimate the total tree height from the stem diameter in an ecotone zone between ombrophilous and seasonal forests in the Brazilian state of Roraima, in northern Amazonia. Stem diameter and total height were measured directly in 65 recently fallen trees (live or dead). Linear and nonlinear regressions were tested to represent the D:H relation in this specific ecotone zone. Criteria for model selection were the standard error of the estimate (Syx) and the adjusted coefficient of determination (R²adj), complemented by the Akaike Information Criterion (AIC). Analysis of residuals of the most parsimonious nonlinear models showed a tendency to overestimate the total tree height for trees in the 20-40 cm diameter range. Application of our best fitted model (Michaelis-Menten) indicated that previously published general equations for the tropics that use diameter as the independent variable can either overestimate tree height in the study area by 10-29% (Weibull models) or underestimate it by 8% (climate-based models). We concluded that our site-specific model can be used in the ecotone forests studied in Roraima because it realistically reflects the local biometric relationships between stem diameter and total tree height. Studies need to be expanded in peripheral areas of northern Amazonia in order to reduce uncertainties in biomass and carbon estimates that use the tree height as a variable in general models.
DOI: 10.6084/m9.figshare.8092442.v1
title: Genetic Population Structure and Allele Surfing During Range Expansion in Dynamic Habitats

description: Abstract: Expanding populations may loss genetic diversity because sequential founder events throughout a wave of demographic expansion may cause “allele surfing”, as the alleles of founder individuals may propagate rapidly through space. The spatial components of allele surfing have been studied by geneticists, but have never been investigate on dynamic and shifting habitats. Here we used an individual-based-model (IBM) to study how interactions between different habitat restoration scenarios and biological characteristics (dispersal capacity) affect the spatial patterns of the genetic structure of a population during demographic expansion. We found that both habitat dynamics and dispersal capacity, as well as their interaction, were the drivers of emergent pattern of genetic diversity and allele surfing. Specifically, allele surfing is more common when a species with low dispersal capacity colonizes a large geographic area with slow restoration (low carrying capacity). Despite this, we showed that allele surfing can be reduced, or even avoided, by dispersal management through suitable habitat restoration. Thus, investigating how colonization generates a spatial variation in genetic diversity, and which parameters control the emergent genetic pattern, are essential steps to planning assisted gene flow, which is fundamental for an effective planning of habitat restoration.