cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.5517/ccdc.csd.cc2p55km
title: CCDC 2477630: Experimental Crystal Structure Determination

description: Related Article: Laureen Busson, Oussama Fayafrou, Elise Lognon, Nicolas Casaretto, Carine Duhayon, Sophie Bourcier, Jean-Baptiste Sortais, Corinne Gosmini, Olivier Baslé, Antonio Monari, Yves Canac, Audrey Auffrant|2025|Inorg.Chem.|||doi:10.1021/acs.inorgchem.5c03589
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2pnhhc
title: CCDC 2492353: Experimental Crystal Structure Determination

description: Related Article: Tanmay Barman, Om Prakash Dash, Jatin Patra, Chandra M. R. Volla|2025|Org.Lett.|||doi:10.1021/acs.orglett.5c04093
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2psjqr
title: CCDC 2496235: Experimental Crystal Structure Determination

description: Related Article: Priyambada Prusty, Masilamani Jeganmohan|2025|Org.Lett.|||doi:10.1021/acs.orglett.5c04508
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2pxgnr
title: CCDC 2500015: Experimental Crystal Structure Determination

description: Related Article: Yu-Ting Luo, Zhi-Hao Xue, Zhen-Wen Zhang, Chen Sun, Yu-Ting Guo, Sai-Jin Xiao, Ru-Ping Liang, Li Zhang, Jian-Ding Qiu|2025|Inorg.Chem.|||doi:10.1021/acs.inorgchem.5c04088
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2pxgtx
title: CCDC 2500020: Experimental Crystal Structure Determination

description: Related Article: Yu-Ting Luo, Zhi-Hao Xue, Zhen-Wen Zhang, Chen Sun, Yu-Ting Guo, Sai-Jin Xiao, Ru-Ping Liang, Li Zhang, Jian-Ding Qiu|2025|Inorg.Chem.|||doi:10.1021/acs.inorgchem.5c04088
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2pxgvy
title: CCDC 2500021: Experimental Crystal Structure Determination

description: Related Article: Yu-Ting Luo, Zhi-Hao Xue, Zhen-Wen Zhang, Chen Sun, Yu-Ting Guo, Sai-Jin Xiao, Ru-Ping Liang, Li Zhang, Jian-Ding Qiu|2025|Inorg.Chem.|||doi:10.1021/acs.inorgchem.5c04088
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2pxgwz
title: CCDC 2500022: Experimental Crystal Structure Determination

description: Related Article: Yu-Ting Luo, Zhi-Hao Xue, Zhen-Wen Zhang, Chen Sun, Yu-Ting Guo, Sai-Jin Xiao, Ru-Ping Liang, Li Zhang, Jian-Ding Qiu|2025|Inorg.Chem.|||doi:10.1021/acs.inorgchem.5c04088
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.15468/dl.zgvwhc
title: Occurrence Download

description: A dataset containing 134 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is Mexico",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 "TaxonKey is Epilachna varivestis"
 ]
}

 The dataset includes 134 records from 7 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0011943-260129131611470/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.5281/zenodo.18484952
title: Septoria glycines isolate SG026 internal transcribed spacer (ITS) sequence

description: Sequence ontained from isolate SG026 PCR product with Oxford Nanopre sequencing technology.
DOI: 10.5281/zenodo.18484953
title: Septoria glycines isolate SG026 internal transcribed spacer (ITS) sequence

description: Sequence ontained from isolate SG026 PCR product with Oxford Nanopre sequencing technology.
DOI: 10.5281/zenodo.18485027
title: BUXGALTERIYA XISOBINING ASOSIY TUSHUNCHALARI VA TAMOYILLARI

description: Maqolada buxgalteriya xisobining asosiy tushunchalari va tamoyillari tizimli tarzda yoritilgan. Asosiy e’tibor xisobning nazariy asoslariga, moliyaviy hisobotlarning shakllanish jarayoniga hamda zamonaviy iqtisodiy muhitda buxgalteriya xisobining roliga qaratilgan. Ishda buxgalteriya xisobini tashkil etuvchi elementlar, aktiv va passiv tushunchalari, moliyaviy natijalarni aniqlash tamoyillari hamda xisobni yuritishning asosiy printsiplari batafsil tahlil qilingan. Shuningdek, maqolada buxgalteriya xisobi orqali korxona faoliyatining samaradorligini oshirish imkoniyatlari va ma’lumotlarning iqtisodiy qaror qabul qilishdagi ahamiyati ham ko‘rib chiqilgan. Tadqiqot natijalari buxgalteriya xisobining nazariy va amaliy jihatlarini yanada chuqurroq tushunishga, shuningdek, moliyaviy hisobotlarni tahlil qilish va boshqaruv qarorlarini qabul qilish jarayonlarini takomillashtirishga yordam beradi.
DOI: 10.5281/zenodo.18485028
title: BUXGALTERIYA XISOBINING ASOSIY TUSHUNCHALARI VA TAMOYILLARI

description: Maqolada buxgalteriya xisobining asosiy tushunchalari va tamoyillari tizimli tarzda yoritilgan. Asosiy e’tibor xisobning nazariy asoslariga, moliyaviy hisobotlarning shakllanish jarayoniga hamda zamonaviy iqtisodiy muhitda buxgalteriya xisobining roliga qaratilgan. Ishda buxgalteriya xisobini tashkil etuvchi elementlar, aktiv va passiv tushunchalari, moliyaviy natijalarni aniqlash tamoyillari hamda xisobni yuritishning asosiy printsiplari batafsil tahlil qilingan. Shuningdek, maqolada buxgalteriya xisobi orqali korxona faoliyatining samaradorligini oshirish imkoniyatlari va ma’lumotlarning iqtisodiy qaror qabul qilishdagi ahamiyati ham ko‘rib chiqilgan. Tadqiqot natijalari buxgalteriya xisobining nazariy va amaliy jihatlarini yanada chuqurroq tushunishga, shuningdek, moliyaviy hisobotlarni tahlil qilish va boshqaruv qarorlarini qabul qilish jarayonlarini takomillashtirishga yordam beradi.
DOI: 10.15468/dl.vmxyqh
title: Occurrence Download

description: A dataset containing 197 species occurrences available in GBIF matching the query:
{
 "and" : [
 "BasisOfRecord is Human Observation",
 "Country is Mexico",
 "Geometry POLYGON((-112.58449 17.34315,-96.41551 17.34315,-96.41551 28.65685,-112.58449 28.65685,-112.58449 17.34315))",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 "TaxonKey is Mammillaria jaliscana"
 ]
}

 The dataset includes 197 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0011944-260129131611470/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.kfcdey
title: Occurrence Download

description: A dataset containing 173 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Brachypelma klaasi"
 ]
}

 The dataset includes 173 records from 5 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0011945-260129131611470/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.gebrde
title: Occurrence Download

description: A dataset containing 243 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Vanilla odorata"
 ]
}

 The dataset includes 243 records from 52 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0011946-260129131611470/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.b7efmr
title: Occurrence Download

description: A dataset containing 510 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Continent is South America",
 "Country is Colombia",
 "Geometry POLYGON((-73.3487 6.90235,-73.40301 6.84608,-73.41245 6.78981,-73.43134 6.73354,-73.4644 6.67021,-73.5258 6.62096,-73.58011 6.53886,-73.58719 6.47786,-73.52107 6.49194,-73.55886 6.41451,-73.53288 6.35114,-73.47857 6.35114,-73.50927 6.30186,-73.40301 6.37931,-73.38412 6.42389,-73.39829 6.47082,-73.35578 6.46378,-73.37703 6.52009,-73.40301 6.56232,-73.38176 6.60454,-73.33453 6.61627,-73.33925 6.67256,-73.3605 6.74057,-73.34397 6.80623,-73.3487 6.90235))",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 "TaxonKey is Amphibia"
 ]
}

 The dataset includes 510 records from 8 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0011947-260129131611470/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.35f99f
title: Occurrence Download

description: A dataset containing 21241 records in GBIF matching the query:
SELECT
 kingdom,
 kingdomkey,
 phylum,
 phylumkey,
 class,
 classkey,
 "order",
 orderkey,
 family,
 familykey,
 genus,
 genuskey,
 species,
 specieskey,
 "year",
 countrycode countrycode,
 IF(ISNULL(kingdomkey), NULL, SUM(COUNT(*)) OVER (
 PARTITION BY kingdomkey, countrycode, "year")) kingdomcount,
 IF(ISNULL(phylumkey), NULL, SUM(COUNT(*)) OVER (
 PARTITION BY phylumkey, countrycode, "year")) phylumcount,
 IF(ISNULL(classkey), NULL, SUM(COUNT(*)) OVER (
 PARTITION BY classkey, countrycode, "year")) classcount,
 IF(ISNULL(orderkey), NULL, SUM(COUNT(*)) OVER (
 PARTITION BY orderkey, countrycode, "year")) ordercount,
 IF(ISNULL(familykey), NULL, SUM(COUNT(*)) OVER (
 PARTITION BY familykey, countrycode, "year")) familycount,
 IF(ISNULL(genuskey), NULL, SUM(COUNT(*)) OVER (
 PARTITION BY genuskey, countrycode, "year")) genuscount,
 COUNT(*) occurrences,
 MIN(GBIF_TEMPORALUNCERTAINTY(eventdate, eventtime)) mintemporaluncertainty,
 MIN(COALESCE(coordinateuncertaintyinmeters, 1000)) mincoordinateuncertaintyinmeters
FROM
 occurrence
WHERE
 occurrence.decimallatitude &gt;= 54.25575
 AND occurrence.decimallatitude &lt;= 54.43089
 AND (occurrence.decimallongitude &gt;= 18.45802 AND occurrence.decimallongitude &lt;= 18.96778)
 AND GBIF_WITHIN('POLYGON ((18.96778 54.36158, 18.5868 54.43089, 18.45802 54.3929, 18.49665 54.30646, 18.79091 54.25575, 18.92651 54.28659, 18.96778 54.36158))', occurrence.decimallatitude, occurrence.decimallongitude) = TRUE
 AND occurrence.hascoordinate = TRUE
 AND occurrence.hasgeospatialissues = FALSE
 AND occurrence.occurrencestatus = 'PRESENT'
 AND NOT GBIF_STRINGARRAYCONTAINS(occurrence.issue, 'TAXON_MATCH_FUZZY', TRUE)
 AND (occurrence.distancefromcentroidinmeters &gt;= 2000.0 OR occurrence.distancefromcentroidinmeters IS NULL)
 AND NOT occurrence.basisofrecord IN ('FOSSIL_SPECIMEN', 'LIVING_SPECIMEN')
 AND (occurrence.classificationdetails['d7dddbf4-2cf0-4f39-9b2a-bb099caae36c']['specieskey'] &lt;&gt; '' AND occurrence."year" IS NOT NULL AND occurrence.hascoordinate = TRUE)
GROUP BY
 occurrence.kingdom,
 occurrence.kingdomkey,
 occurrence.phylum,
 occurrence.phylumkey,
 occurrence.class,
 occurrence.classkey,
 occurrence."order",
 occurrence.orderkey,
 occurrence.family,
 occurrence.familykey,
 occurrence.genus,
 occurrence.genuskey,
 occurrence.species,
 occurrence.specieskey,
 occurrence."year",
 occurrence.countrycode

 The dataset's 21241 records were derived from 149 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0011895-260129131611470/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.zunfuz
title: Occurrence Download

description: A dataset containing 8237 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is Mexico",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "TaxonKey is Nasua narica"
 ]
}

 The dataset includes 8237 records from 95 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0011949-260129131611470/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.5281/zenodo.18484295
title: data
DOI: 10.5281/zenodo.18484296
title: data
DOI: 10.15468/dl.5t4nz5
title: Occurrence Download

description: A dataset containing 23553 species occurrences available in GBIF matching the query:
{
 "and" : [
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 "TaxonKey is Oncorhynchus",
 "Year 1500-1950"
 ]
}

 The dataset includes 23553 records from 71 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0011948-260129131611470/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.5281/zenodo.18478809
title: Replication data for: Data trading platforms and urban economic vitality: evidence from China
DOI: 10.15468/dl.km349a
title: Occurrence Download

description: A dataset containing 43 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is Mexico",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "TaxonKey is Acontista cordillerae"
 ]
}

 The dataset includes 43 records from 2 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0011950-260129131611470/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.5281/zenodo.18485050
title: BUXGALTERIYA XISOBINING BOZOR IQTISODIYOTIDAGI O'RNI

description: Mazkur maqolada buxgalteriya hisobining bozor iqtisodiyoti sharoitidagi o‘rni va ahamiyati kompleks yondashuv asosida tahlil qilinadi. Bozor munosabatlarining chuqurlashuvi, raqobat muhitining kuchayishi hamda xo‘jalik yurituvchi subyektlar faoliyatida shaffoflikka bo‘lgan talabning ortishi buxgalteriya hisobining iqtisodiy boshqaruvdagi rolini tubdan oshirmoqda. Tadqiqot davomida buxgalteriya hisobining moliyaviy axborot manbai sifatidagi vazifalari, qaror qabul qilish jarayonidagi ahamiyati hamda investorlar, kreditorlar va davlat organlari uchun ishonchli ma’lumotlar taqdim etishdagi funksiyalari yoritib berilgan. Shuningdek, bozor iqtisodiyoti sharoitida buxgalteriya hisobining xalqaro standartlarga moslashuvi, raqamlashtirish jarayonlari va ularning iqtisodiy samaradorlikka ta’siri tahlil qilinadi. Maqolada buxgalteriya hisobining faqatgina hisob-kitob vositasi emas, balki iqtisodiy barqarorlikni ta’minlovchi muhim boshqaruv instrumenti ekanligi ilmiy asosda ochib beriladi.
DOI: 10.5281/zenodo.18485049
title: BUXGALTERIYA XISOBINING BOZOR IQTISODIYOTIDAGI O'RNI

description: Mazkur maqolada buxgalteriya hisobining bozor iqtisodiyoti sharoitidagi o‘rni va ahamiyati kompleks yondashuv asosida tahlil qilinadi. Bozor munosabatlarining chuqurlashuvi, raqobat muhitining kuchayishi hamda xo‘jalik yurituvchi subyektlar faoliyatida shaffoflikka bo‘lgan talabning ortishi buxgalteriya hisobining iqtisodiy boshqaruvdagi rolini tubdan oshirmoqda. Tadqiqot davomida buxgalteriya hisobining moliyaviy axborot manbai sifatidagi vazifalari, qaror qabul qilish jarayonidagi ahamiyati hamda investorlar, kreditorlar va davlat organlari uchun ishonchli ma’lumotlar taqdim etishdagi funksiyalari yoritib berilgan. Shuningdek, bozor iqtisodiyoti sharoitida buxgalteriya hisobining xalqaro standartlarga moslashuvi, raqamlashtirish jarayonlari va ularning iqtisodiy samaradorlikka ta’siri tahlil qilinadi. Maqolada buxgalteriya hisobining faqatgina hisob-kitob vositasi emas, balki iqtisodiy barqarorlikni ta’minlovchi muhim boshqaruv instrumenti ekanligi ilmiy asosda ochib beriladi.
DOI: 10.15468/dl.aeavut
title: Occurrence Download

description: A dataset containing 748 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Phalanta alcippe"
 ]
}

 The dataset includes 748 records from 36 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0011951-260129131611470/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.fnrtmu
title: Occurrence Download

description: A dataset containing 14175 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Cotinis mutabilis"
 ]
}

 The dataset includes 14175 records from 76 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0011957-260129131611470/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.mhqcrd
title: Occurrence Download

description: A dataset containing 315 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Amphichaetodon howensis"
 ]
}

 The dataset includes 315 records from 29 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0011956-260129131611470/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.xsrqrk
title: Occurrence Download

description: A dataset containing 10 species occurrences available in GBIF matching the query:
{
 "and" : [
 "BasisOfRecord is one of (Occurrence evidence, Human Observation, Specimen)",
 "Country is United States of America",
 "GadmGid is USA.10_1",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 "TaxonKey is Atractosteus spatula"
 ]
}

 The dataset includes 10 records from 6 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0011960-260129131611470/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.fsvwxm
title: Occurrence Download

description: A dataset containing 21397 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Loxodonta africana",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 {
 "or" : [
 {
 "not" : {
 "EstablishmentMeans" : [
 "is one of (MANAGED, INTRODUCED)"
 ]
 }
 },
 "EstablishmentMeans is null"
 ]
 }
 ]
}

 The dataset includes 21397 records from 72 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0011958-260129131611470/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.5281/zenodo.18485076
title: Septoria glycines isolate SG026 elongation factor (EF) sequence

description: Sequence obtained from isolate SG026 PCR product with Oxford Nanopre sequencing technology.
DOI: 10.5281/zenodo.18485075
title: Septoria glycines isolate SG026 elongation factor (EF) sequence

description: Sequence obtained from isolate SG026 PCR product with Oxford Nanopre sequencing technology.
DOI: 10.5281/zenodo.10286698
title: Preprocessed dataset from: Opioid-Specific Brain Connectivity Dynamics Distinguish Analgesia from Secondary Effects

description: The µ-opioid receptor (MOP) is a critical pharmaceutical target that mediates both the therapeutic benefits and adverse effects of opioid drugs. However, the large-scale neural circuit dynamics underlying key opioid effects, such as analgesia and respiratory depression, remain poorly understood, hindering the development of safer analgesics. Here, we present a multimodal experimental framework that integrates functional ultrasound imaging (fUSI) through the intact skull with behavioral and molecular analyses to investigate opioid-induced large-scale functional responses and their physiological relevance in awake, behaving mice. Administration of major opioids—morphine, fentanyl, methadone, and buprenorphine—elicited robust, dose- and time-dependent reorganization of functional brain connectivity (FC) patterns, with magnitude scaling according to MOP agonist efficacy. This opioid-specific functional fingerprint is marked by decreased FC between the somatosensory cortex and hippocampal/thalamic regions and increased bilateral subcortical FC within the somatosensory cortex. Notably, this fingerprint was attenuated following tolerance induction and abolished by pharmacological or genetic MOP inactivation. Through power Doppler spectral analysis and lagged correlation measurements, we show that morphine perturbs temporal FC dynamics and the propagation of brain-wide oscillatory activity, disrupting critical-state dynamics. Importantly, we identify a dissociation between fast, transient processes—such as cerebral blood volume (CBV) changes, locomotion, and respiratory depression—and slower processes driving FC reorganization, analgesia, and sustained MOP activation. This study provides mechanistic insights into opioid-induced network reorganization, establishes FC alterations as a reliable biomarker of opioid efficacy, and offers a framework for advancing the development of analgesic compounds with improved therapeutic windows and reduced side effects.