cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.9805052
title: Snail Foraging Data.xlsx from Resource distribution and internal factors interact to govern movement of a freshwater snail

description: Movement enables mobile organisms to respond to local environmental conditions and is driven by a combination of external and internal factors operating at multiple scales. Here, we explored how resource distribution interacted with the internal state of organisms to drive patterns of movement. Specifically, we tracked snail movements on experimental landscapes where resource (algal biofilm) distribution varied from 0 to 100% coverage and quantified how that movement changed over a 24 h period. Resource distribution strongly affected snail movement. Trajectories were tortuous (i.e. Brownian-like) within resource patches but straighter (i.e. Lévy) in resource-free (bare) patches. The average snail speed was slower in resource patches, where snails spent most of their time. Different patterns of movement between resource and bare patches explained movement at larger spatial scales; movement was ballistic-like Lévy in resource-free landscapes, Lévy in landscapes with intermediate resource coverage and approximated Brownian in landscapes covered in resources. Our temporal analysis revealed that movement patterns changed predictably for snails that satiated their hunger and then performed other behaviours. These changes in movement patterns through time were similar across all treatments that contained resources. Thus, external and internal factors interacted to shape the inherently flexible movement of these snails.
DOI: 10.6084/m9.figshare.9804860
title: CF WC + F vs NCF WC + F

description: Compare CF and NCF cultures at time of wound closure (WC) in cells exposed to flagellin (F).
DOI: 10.6084/m9.figshare.9804869
title: Hala and Ahmed file.sav

description: this data of primary school student their age between 6 -14 years old, included the results of stool samples by three parasitological methods. <br>
DOI: 10.6084/m9.figshare.9804857
title: CF NW+F vs NCF NW+F

description: Compare well-differentiated (not wounded, NW) CF vs NCF cultures exposed to flagellin (F).
DOI: 10.6084/m9.figshare.9804860.v1
title: CF WC + F vs NCF WC + F

description: Compare CF and NCF cultures at time of wound closure (WC) in cells exposed to flagellin (F).
DOI: 10.6084/m9.figshare.9804851
title: CF NW+F vs CF NW

description: Effect of flagellin (F) on well-differentiated (non wounded, NW) CF cultures.
DOI: 10.6084/m9.figshare.9804854
title: CF WC+F vs CF WC

description: Effects of flagellin (F) on CF cultures at time of wound closure (WC).
DOI: 10.6084/m9.figshare.9804857.v1
title: CF NW+F vs NCF NW+F

description: Compare well-differentiated (not wounded, NW) CF vs NCF cultures exposed to flagellin (F).
DOI: 10.6084/m9.figshare.9804869.v1
title: Hala and Ahmed file.sav

description: this data of primary school student their age between 6 -14 years old, included the results of stool samples by three parasitological methods. <br>
DOI: 10.6084/m9.figshare.9804896.v1
title: Antimicrobial activity of secretions produced by red palm weevils

description: External secretions play a vital role in external immune defense. However, the functions of these exudates are largely unknown in the red palm weevil, <i>Rhynchophorus ferrugineus</i> (Olivier) (Coleoptera: Curculionidae). In order to determine their role in external immunity, the immunosuppressive efficacy of the secretions <i>in vitro</i> against microbes, including bacteria and fungi, was clarified. In the present study, we found that these secretions had antimicrobial activity <i>in vitro</i>, implying external immunizing potency against pathogens. Surprisingly, all liquid phases of secretions could not significantly inhibit the growth of microbes <i>in vitro</i> compared to solid phases.
DOI: 10.6084/m9.figshare.9804848
title: NCF WC+F vs NCF WC

description: Effect of flagellin (F) on NCF cultures at time of wound closure (WC).
DOI: 10.6084/m9.figshare.9804845
title: NCF NW+F vs NCF NW

description: Effect of flagellin (F) on well-differentiated (non wounded, NW) NCF cultures.
DOI: 10.6084/m9.figshare.9804854.v1
title: CF WC+F vs CF WC

description: Effects of flagellin (F) on CF cultures at time of wound closure (WC).
DOI: 10.6084/m9.figshare.9804845.v1
title: NCF NW+F vs NCF NW

description: Effect of flagellin (F) on well-differentiated (non wounded, NW) NCF cultures.
DOI: 10.6084/m9.figshare.9804848.v1
title: NCF WC+F vs NCF WC

description: Effect of flagellin (F) on NCF cultures at time of wound closure (WC).
DOI: 10.6084/m9.figshare.9804851.v1
title: CF NW+F vs CF NW

description: Effect of flagellin (F) on well-differentiated (non wounded, NW) CF cultures.
DOI: 10.6084/m9.figshare.9804896.v2
title: Antimicrobial activity of secretions produced by red palm weevils

description: External secretions play a vital role in external immune defense. However, the functions of these exudates are largely unknown in the red palm weevil, <i>Rhynchophorus ferrugineus</i> (Olivier) (Coleoptera: Curculionidae). In order to determine their role in external immunity, the immunosuppressive efficacy of the secretions <i>in vitro</i> against microbes, including bacteria and fungi, was clarified. In the present study, we found that these secretions had antimicrobial activity <i>in vitro</i>, implying external immunizing potency against pathogens. Surprisingly, all liquid phases of secretions could not significantly inhibit the growth of microbes <i>in vitro</i> compared to solid phases.
DOI: 10.6084/m9.figshare.9804833
title: CF pWC vs NCF pWC

description: Compare CF and NCF cultures 2-days post wound closure (pWC).
DOI: 10.6084/m9.figshare.9804842
title: CF WC+F vs CF NW+F

description: Compare CF cultures between time of wound closure (WC) and non wounded (NW) conditions exposed to flagellin (F).
DOI: 10.6084/m9.figshare.9804830
title: CF WC vs NCF WC

description: Compare CF and NCF cultures at time of wound closure (WC).
DOI: 10.6084/m9.figshare.9804839
title: NCF WC+F vs NCF NW+F

description: Compare NCF cultures between time of wound closure (WC) and non wounded (NW) conditions exposed to flagellin (F).
DOI: 10.6084/m9.figshare.9804842.v1
title: CF WC+F vs CF NW+F

description: Compare CF cultures between time of wound closure (WC) and non wounded (NW) conditions exposed to flagellin (F).
DOI: 10.6084/m9.figshare.9804896.v3
title: Antimicrobial activity of external secretions produced by red palm weevils

description: External secretions play a vital role in external immune defense. However, the functions of these exudates are largely unknown in the red palm weevil, <i>Rhynchophorus ferrugineus</i> (Olivier) (Coleoptera: Curculionidae). In order to determine their role in external immunity, the immunosuppressive efficacy of the secretions <i>in vitro</i> against microbes, including bacteria and fungi, was clarified. In the present study, we found that these secretions had antimicrobial activity <i>in vitro</i>, implying external immunizing potency against pathogens. Surprisingly, all liquid phases of secretions could not significantly inhibit the growth of microbes <i>in vitro</i> compared to solid phases.
DOI: 10.6084/m9.figshare.9804896.v4
title: External immune inhibitory efficiency of external secretions and their metabolic profiling in red palm weevil, Rhynchophorus ferrugineus (Coleoptera: Curculionidae)

description: External secretions play a vital role in external immune defense. However, the functions and components of these exudates are largely unknown in the red palm weevil, <i>Rhynchophorus ferrugineus</i> (Olivier) (Coleoptera: Curculionidae). In order to determine their role in external immunity, the immunosuppressive efficacy of the secretions <i>in vitro</i> against microbes, including bacteria and fungi, was clarified. In the present study, we found that these secretions had antimicrobial activity <i>in vitro</i>, implying external immunizing potency against pathogens. Surprisingly, all liquid phases of secretions could not significantly inhibit the growth of microbes <i>in vitro</i> compared to solid phases. To explain this phenomenon, the composition and emission differentia of secretions from the exocrine glands associated with different developmental stages, secretory regions and phases were identified and analyzed based on metabonomics technique. A total of more than two hundred compounds, including quinines, phenols, aldehydes, acids, alcohols, saccharides, ketones, esters, amines, salts, ureas and heterocycles, were identified in the secretions of larvae and adults. The liquid phase shared a number of metabolites with the solid phase, but the emission types and amounts were significantly different in the two phases, resulting in differences in external immunological activity. Tyrosine and p-benzoquinone were the dominant metabolites in all of the secretions, accounting for approximately 11.29% of emissions, with the portion in the solid phase being generally higher than the liquid phase. Moreover, only p-benzoquinone was entirely significantly up-regulated in the solid phase compared to the liquid phase. Therefore, metabolome analysis suggested that p-benzoquinone, which may potentially be developed to be a valuable marker for determining external immunity, was considered to be the main substance responsible for external immune functions. This hypothesis was further demonstrated by the antimicrobial activity of p-benzoquinone.
DOI: 10.6084/m9.figshare.9804830.v1
title: CF WC vs NCF WC

description: Compare CF and NCF cultures at time of wound closure (WC).
DOI: 10.6084/m9.figshare.9804833.v1
title: CF pWC vs NCF pWC

description: Compare CF and NCF cultures 2-days post wound closure (pWC).
DOI: 10.6084/m9.figshare.9804839.v1
title: NCF WC+F vs NCF NW+F

description: Compare NCF cultures between time of wound closure (WC) and non wounded (NW) conditions exposed to flagellin (F).
DOI: 10.6084/m9.figshare.9804827
title: CF pW vs NCF pW

description: Compare CF and NCF cultures 24h after wounding (pW).
DOI: 10.6084/m9.figshare.9804812
title: NCF pWC vs NCF WC

description: Compare NCF cultures 2-days post wound closure (pWC) and at time of WC.
DOI: 10.6084/m9.figshare.9804815
title: CF pWC vs CF WC

description: Compare CF cultures 2-days post wound closure (pWC) and at time of WC.
DOI: 10.6084/m9.figshare.9804821
title: CF NW vs NCF NW

description: Compare well-differentiated (non wounded, NW) CF and NCF cultures.
DOI: 10.6084/m9.figshare.9804806
title: NCF WC vs NCF pW

description: Compare NCF cultures at time of wound closre (WC) and non wounded (NW) conditions.
DOI: 10.6084/m9.figshare.9804812.v1
title: NCF pWC vs NCF WC

description: Compare NCF cultures 2-days post wound closure (pWC) and at time of WC.
DOI: 10.6084/m9.figshare.9804827.v1
title: CF pW vs NCF pW

description: Compare CF and NCF cultures 24h after wounding (pW).
DOI: 10.6084/m9.figshare.9804806.v1
title: NCF WC vs NCF pW

description: Compare NCF cultures at time of wound closre (WC) and non wounded (NW) conditions.
DOI: 10.6084/m9.figshare.9804815.v1
title: CF pWC vs CF WC

description: Compare CF cultures 2-days post wound closure (pWC) and at time of WC.
DOI: 10.6084/m9.figshare.9804821.v1
title: CF NW vs NCF NW

description: Compare well-differentiated (non wounded, NW) CF and NCF cultures.
DOI: 10.6084/m9.figshare.9804794
title: CF pW vs CF NW

description: Compare CF cultures 24h after wounding (pW) and non wounded (NW) conditions.
DOI: 10.6084/m9.figshare.9804797
title: CF WC vs CF NW

description: Compare CF cultures at time of wound closure (WC) and non wounded (NW) conditions.
DOI: 10.6084/m9.figshare.9804800
title: CF pWC vs CF NW

description: Compere CF cultures 2-days after wound closure (pWC) and non wounded (NW) conditions.
DOI: 10.6084/m9.figshare.9804788
title: NCF WC vs NCF NW

description: Compare NCF cultures at time of wound closure (WC) and non wounded (NW) conditions.
DOI: 10.6084/m9.figshare.9804791
title: NCF pWC vs NCF NW

description: Compare NCF cultures 2-days after wound closure (pWC) and non wounded (NW) conditions.
DOI: 10.6084/m9.figshare.9804794.v1
title: CF pW vs CF NW

description: Compare CF cultures 24h after wounding (pW) and non wounded (NW) conditions.
DOI: 10.6084/m9.figshare.9804797.v1
title: CF WC vs CF NW

description: Compare CF cultures at time of wound closure (WC) and non wounded (NW) conditions.
DOI: 10.6084/m9.figshare.9804788.v1
title: NCF WC vs NCF NW

description: Compare NCF cultures at time of wound closure (WC) and non wounded (NW) conditions.
DOI: 10.6084/m9.figshare.9804791.v1
title: NCF pWC vs NCF NW

description: Compare NCF cultures 2-days after wound closure (pWC) and non wounded (NW) conditions.
DOI: 10.6084/m9.figshare.9804800.v1
title: CF pWC vs CF NW

description: Compere CF cultures 2-days after wound closure (pWC) and non wounded (NW) conditions.
DOI: 10.6084/m9.figshare.9804785
title: NCF pW vs NCF NW

description: Compare NCF cultures 24h post wounding (pW) and non wounded (NW) conditions.
DOI: 10.6084/m9.figshare.9804764
title: Supp Table 4

description: The sequences of 3 siRNA used for Sec23ip knock down.
DOI: 10.6084/m9.figshare.9804764.v1
title: Supp Table 4

description: The sequences of 3 siRNA used for Sec23ip knock down.
DOI: 10.6084/m9.figshare.9804785.v1
title: NCF pW vs NCF NW

description: Compare NCF cultures 24h post wounding (pW) and non wounded (NW) conditions.
DOI: 10.6084/m9.figshare.9804746
title: Supp Table 2

description: A selected list of 14-3-3γ interactome containing proteins that showed consistent interactions at all time points across n= 3.
DOI: 10.6084/m9.figshare.9804752
title: Supp Table 3

description: Relative gene expression for Sec23ip in steroidogenic tissues in human and mice. This data was obtained from biogps database using the probeset 209175-at for human and probeset 1433627-at for mice.
DOI: 10.6084/m9.figshare.9804746.v1
title: Supp Table 2

description: A selected list of 14-3-3γ interactome containing proteins that showed consistent interactions at all time points across n= 3.
DOI: 10.6084/m9.figshare.9804752.v1
title: Supp Table 3

description: Relative gene expression for Sec23ip in steroidogenic tissues in human and mice. This data was obtained from biogps database using the probeset 209175-at for human and probeset 1433627-at for mice.
DOI: 10.6084/m9.figshare.9804662
title: Increasing knowledge of Antarctic biodiversity: new endemic taxa of tardigrades (Eutardigrada; Ramazzottiidae) and their evolutionary relationships

description: The underestimation of biodiversity and scarce knowledge of the biogeographic distributions of terrestrial meiofaunal component limit our understanding of the origin of Antarctic fauna. One of its main components is tardigrades; nonetheless studies on tardigrade diversity are still few in the continental Antarctic area. In order to increase our knowledge of the underreported terrestrial meiofaunal communities within continental Antarctica, as well as to provide new information for biogeographic and evolutionary analysis of these communities, the tardigrade diversity of 11 samples collected along the coast of Victoria Land was considered. The application of an integrative approach in which morphological (Light – LM, scanning electron – SEM, and confocal laser scanning microscopy – CSLM) and molecular analysis (18S, 28S, <i>cox1</i> genes) were combined allowed us to characterize the tardigrade fauna inhabiting mosses, lichens, and cyanobacterial mats of Victoria Land. These analyses allowed the detection of two tardigrade species new to science (<i>Cryoconicus antiarktos</i> sp. nov., <i>Ramazzottius sabatiniae</i> sp. nov.), and the emendation of known species ((<i>Hebesuncus ryani</i> Dastych and Harris, 1994, <i>Ramazzottius nivalis</i> Dastych, 2006, <i>Cryoconicus ljudmilae</i> comb. nov. (Biserov, 1997/98), and <i>Cryoconicus cataphractus</i> (Maucci, 1974)), together with the genus <i>Cryoconicus</i>. The Ramazzottius type of claws was redefined identifying three subtypes. Also, we investigated the phylogenetic position of some problematic/unresolved lineages all belonging to the family Ramazzottiidae. These data increased the knowledge of the biodiversity in Victoria Land, the number of endemic tardigrades in Antarctica, and provided evidence on the origin of Antarctic endemism. Lastly, new methods for integrative taxonomic studies on tardigrades were presented and discussed.
DOI: 10.6084/m9.figshare.9804662.v1
title: Increasing knowledge of Antarctic biodiversity: new endemic taxa of tardigrades (Eutardigrada; Ramazzottiidae) and their evolutionary relationships

description: The underestimation of biodiversity and scarce knowledge of the biogeographic distributions of terrestrial meiofaunal component limit our understanding of the origin of Antarctic fauna. One of its main components is tardigrades; nonetheless studies on tardigrade diversity are still few in the continental Antarctic area. In order to increase our knowledge of the underreported terrestrial meiofaunal communities within continental Antarctica, as well as to provide new information for biogeographic and evolutionary analysis of these communities, the tardigrade diversity of 11 samples collected along the coast of Victoria Land was considered. The application of an integrative approach in which morphological (Light – LM, scanning electron – SEM, and confocal laser scanning microscopy – CSLM) and molecular analysis (18S, 28S, <i>cox1</i> genes) were combined allowed us to characterize the tardigrade fauna inhabiting mosses, lichens, and cyanobacterial mats of Victoria Land. These analyses allowed the detection of two tardigrade species new to science (<i>Cryoconicus antiarktos</i> sp. nov., <i>Ramazzottius sabatiniae</i> sp. nov.), and the emendation of known species ((<i>Hebesuncus ryani</i> Dastych and Harris, 1994, <i>Ramazzottius nivalis</i> Dastych, 2006, <i>Cryoconicus ljudmilae</i> comb. nov. (Biserov, 1997/98), and <i>Cryoconicus cataphractus</i> (Maucci, 1974)), together with the genus <i>Cryoconicus</i>. The Ramazzottius type of claws was redefined identifying three subtypes. Also, we investigated the phylogenetic position of some problematic/unresolved lineages all belonging to the family Ramazzottiidae. These data increased the knowledge of the biodiversity in Victoria Land, the number of endemic tardigrades in Antarctica, and provided evidence on the origin of Antarctic endemism. Lastly, new methods for integrative taxonomic studies on tardigrades were presented and discussed.
DOI: 10.6084/m9.figshare.9804599
title: Supplementary Material for: Dapsone in a Large Tertiary Center: Outdated Therapeutic Option or Timeless Agent?

description: <b><i>Background:</i></b> The ancient drug dapsone has antimicrobial and anti-inflammatory features. In dermatology, dapsone is primarily used for neutrophil-dominant skin diseases. However, real-life data assessing the long-term efficacy of dapsone across multiple dermatological diseases is missing. ­<b><i>Objectives:</i></b> To determine the efficacy and safety of dapsone in patients with inflammatory skin diseases treated at the Department of Dermatology of the University Hospital Zurich. <b><i>Methods:</i></b> The hospital database was searched for patients treated with dapsone in the last 20 years (from January 1, 1998, to December 31, 2017). Overall, 175 patients were included in our study. <b><i>Results:</i></b> Thirty-four patients received dapsone for eosinophilic dermatoses, 82 for neutrophilic dermatoses and 59 for other dermatoses. After 3 months, 8% of all patients reached complete remission, 40.6% showed improvement, 30.3% had stable disease, and only 9.1% had disease progression. Final treatment evaluation revealed complete response in 13.2%, disease improvement in 47.4%, stable disease in 25.7% and disease progression in only 12.0%. Patients who showed remission or improvement after 3 months were significantly older than patients with stable or progressive disease. In addition, remission after 3 months was associated with a significantly lower dose of dapsone compared to improvement only. Hemolysis was the most common adverse event (21.7%). <b><i>Conclusions:</i></b> Our data show that dapsone is a valid treatment option in various dermatological diseases, leading to a favorable response in the vast majority of patients. In addition, it is well tolerated, safe and inexpensive. Randomized, controlled trials are needed to further elucidate the role of this high-potential drug.
DOI: 10.6084/m9.figshare.9804611
title: Supplementary Material for: Efficacy of Calcipotriol-Betamethasone Ointment in Patients with Mild to Moderate Plaque Psoriasis: Subgroup Analyses

description: <b><i>Background:</i></b> Several factors have been shown to affect psoriasis pathogenesis, clinical presentation and treatment response. <b><i>Objectives:</i></b> The aim of this study was to investigate the potential relationship between patients’ baseline characteristics and the efficacy of calcipotriol-betamethasone ointment in patients with mild to moderate plaque psoriasis and to evaluate whether the efficacy is consistent across subgroups. <b><i>Method:</i></b> Using data from the therapeutic equivalence study on patients with plaque psoriasis, post hoc analyses were performed to evaluate the impact of baseline demographic and disease characteristics, habits and comorbidities on the response to treatment with calcipotriol-betamethasone ointment. <b><i>Results:</i></b> Body mass index (BMI) and obesity were each independently associated (univariate analysis, <i>p</i> &lt; 0.05) with reduction in modified Psoriasis Area and Severity Index (mPASI) and PASI75 (≥75% improvement in mPASI from baseline). Increased body weight is more common in patients with late-onset psoriasis. There was a significant trend for lower response rates with increasing BMI (<i>p</i> = 0.007) and obesity (<i>p</i> = 0.003). The odds of achieving PASI75 is 2.3 times lower for obese compared to normal-weight subjects.<i></i>If patients with obesity or hypertension were treated with calcipotriol-betamethasone, they were still more likely to achieve PASI75 after 4-week treatment compared to vehicle (<i>p</i> &lt; 0.001). <b><i>Conclusion:</i></b> Increased BMI and obesity present risk factors for reduced treatment effectiveness. Importantly, the efficacy of calcipotriol-betamethasone ointment was consistent in all subgroups.
DOI: 10.6084/m9.figshare.9804572
title: Supp Table 1.xls

description: A list of proteins from the 14-3-3γ interactome in cAMP-treated MA-10 cells at times 0, 30, 60 and 120. The proteins are listed based on progressive increase in interactions with 14-3-3γ.
DOI: 10.6084/m9.figshare.9804566
title: MEC-R and MEC-S

description: A mecillinam resistant and susceptible E. coli isolate from the same patient
DOI: 10.6084/m9.figshare.9804572.v1
title: Supp Table 1.xls

description: A list of proteins from the 14-3-3γ interactome in cAMP-treated MA-10 cells at times 0, 30, 60 and 120. The proteins are listed based on progressive increase in interactions with 14-3-3γ.