cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.7398833.v1
title: Defining requirements for an Augmented Reality system to overcome the challenges of creating and using design representations in co-design sessions

description: Within co-design sessions involving designers and non-designers, the type and characteristics of the design representations employed is known to impact the performance of such sessions in terms of idea generation, idea evaluation and communication. This study captures the challenges practitioners face in creating and using design representations for co-design sessions and goes on to investigate the potential of Spatial Augmented Reality (SAR) to overcome those challenges. The advantages of SAR in this application are that, multiple concepts can be represented using one physical model, concepts can be modified live during the session, and additional equipment (such as head mounted displays or handheld devices) is not required, thus eliminating any possible interference with the natural interactions between participants. Interviews with design practitioners and trials with a prototype SAR system are used to identify the key challenges faced by practitioners in their current use of design representations, and to capture the technology requirements for a SAR system for use in co-design sessions. These findings can inform the work of technology developers and researchers working on systems to support co-design sessions.
DOI: 10.7284/119952
title: Rain Gauge data collected during research cruise OC1405A using a RM Young 50202 instrument system onboard the platform RV Oceanus

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7398788
title: Hybrid Hierarchical Linear Model-System Dynamics (HLMSD) Models for Predicting and Monitoring the Bridge Deterioration

description: This data is the result of recording the bridge and its component's condition based on BMS guidelines. It is used to model the Hybrid Hierarchical Linear Model-System Dynamics (HLMSD) for Predicting and Monitoring the Bridge Deterioration. This model is needed not only to predict the condition of the bridge and its components themselves but also to predict its failure in order to avoid collapse suddenly. Furthermore, based on the results of this research, this model can also be used as a reference to determine the period of maintenance and repair of bridges based on the specified requirements. This study can still develop in advanced so that the model can always update its data by itself which becomes more valid. It can also be equipped with additional equipment to be able to assess conditions and predictions automatically in order to monitor bridge reliability well.
DOI: 10.7284/119943
title: Singlebeam Echosounder data collected during research cruise OC1405A using a Knudsen 3260 instrument system onboard the platform RV Oceanus

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/119945
title: Singlebeam Echosounder data collected during research cruise OC1405A using a Knudsen 3260 instrument system onboard the platform RV Oceanus

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/119953
title: Speedlog data collected during research cruise OC1405A using a Furuno DS-50 instrument system onboard the platform RV Oceanus

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/119941
title: Water Temperature data collected during research cruise OC1405A using a Sea-Bird SBE-48 instrument system onboard the platform RV Oceanus

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/119954
title: Water Temperature data collected during research cruise OC1405A using a Sea-Bird SBE-38 instrument system onboard the platform RV Oceanus

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/119955
title: Transmissometer data collected during research cruise OC1405A using a WET Labs C-Star instrument system onboard the platform RV Oceanus

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/119956
title: TSG (Thermosalinograph) data collected during research cruise OC1405A using a Sea-Bird SBE-45 instrument system onboard the platform RV Oceanus

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/119961
title: Anemometer data collected during research cruise OC1405B using a Gill WindObserver II instrument system onboard the platform RV Oceanus

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7398659
title: Shoot apical meristem

description: Loop animation schematizing cell divisions in the apical dome of a shoot meristem.#plantillustrations
DOI: 10.7284/119963
title: Fluorometer data collected during research cruise OC1405B using a WET Labs WETStar instrument system onboard the platform RV Oceanus

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7398659.v2
title: Shoot apical meristem

description: Loop animation schematizing cell divisions in the apical dome of a shoot meristem.#plantillustrations
DOI: 10.7284/117342
title: GNSS (Global Navigation Satellite System) data collected during research cruise OC1405B using a Ashtech ADU5 instrument system onboard the platform RV Oceanus

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7398641
title: Endocuticle sclerotisation increases mechanical stability of cuticle

description: These are the raw data of the paper "Endocuticle sclerotisation increases mechanical stability of cuticle" by Lu-Yi Wang, Mohsen Jafarpour, Chung-Ping Lin, Esther Appel, Stanislav N. Gorb and Hamed Rajabi<br>
DOI: 10.6084/m9.figshare.7398641.v1
title: Endocuticle sclerotisation increases mechanical stability of cuticle

description: These are the raw data of the paper "Endocuticle sclerotisation increases mechanical stability of cuticle" by Lu-Yi Wang, Mohsen Jafarpour, Chung-Ping Lin, Esther Appel, Stanislav N. Gorb and Hamed Rajabi<br>
DOI: 10.7284/119964
title: Gyrocompass data collected during research cruise OC1405B using a Sperry MK-37 instrument system onboard the platform RV Oceanus

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/119966
title: Hygrometer data collected during research cruise OC1405B using a Vaisala HMT300 instrument system onboard the platform RV Oceanus

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/119965
title: PTU (Pressure, Temperature, Humidity) data collected during research cruise OC1405B using a Vaisala PTU300 instrument system onboard the platform RV Oceanus

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7398593
title: Herbal Tea Safety and Efficacy Review

description: Spreadsheet of the workings of a scoping review process with inclusion and exclusion criteria for selecting articles. The topic explored clinical trials and population studies on the efficacy and safety of herbal tea beverage consumption. The data steps through the scoping review process and compiles data into a chart.
DOI: 10.6084/m9.figshare.7398551
title: Supplementary Material for: Serum Bilirubin and Albumin in Anti-<b><i>N</i></b>-Methyl-D-Aspartate Receptor Encephalitis

description: <b><i>Background and Objective:</i></b> Low serum levels of bilirubin and albumin are associated with multiple autoimmune diseases, but their<b><i></i></b> role in anti-<i>N</i>-methyl-D-aspartate receptor (anti-NMDAR) encephalitis is unknown. <b><i>Methods:</i></b> Serum bilirubin and albumin levels were evaluated in 60 patients with anti-NMDAR encephalitis, 50 cryptococcal encephalitis, and 145 healthy controls (CTLs). Of the 60 anti-NMDAR encephalitis patients, 30 had a follow-up evaluation at 3 months after admission. <b><i>Results:</i></b> Serum bilirubin and albumin levels were both significantly lower in anti-NMDAR encephalitis than in CTLs, and serum bilirubin levels were significantly lower in anti-NMDAR encephalitis than in cryptococcal encephalitis. Serum bilirubin levels were significantly lower in patients with psychiatric symptoms, with severe impairment, and with limited responses to treatment than those without psychiatric symptoms, with mild impairment, and with favorable responses to treatment, respectively. A follow-up evaluation of 30 patients revealed that the modified Rankin Scale scores were significantly decreased after treatment. Serum bilirubin significantly associated with serum albumin, and plasma hemoglobin. <b><i>Conclusions:</i></b> Our results revealed for the first time an association between the serum levels of bilirubin in the anti-NMDAR encephalitis. Further studies investigating the role of bilirubin and albumin in anti-NMDAR encephalitis are required.
DOI: 10.7284/119967
title: Radiometer data collected during research cruise OC1405B using a RMR Co. PRP instrument system onboard the platform RV Oceanus

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7398551.v1
title: Supplementary Material for: Serum Bilirubin and Albumin in Anti-<b><i>N</i></b>-Methyl-D-Aspartate Receptor Encephalitis

description: <b><i>Background and Objective:</i></b> Low serum levels of bilirubin and albumin are associated with multiple autoimmune diseases, but their<b><i></i></b> role in anti-<i>N</i>-methyl-D-aspartate receptor (anti-NMDAR) encephalitis is unknown. <b><i>Methods:</i></b> Serum bilirubin and albumin levels were evaluated in 60 patients with anti-NMDAR encephalitis, 50 cryptococcal encephalitis, and 145 healthy controls (CTLs). Of the 60 anti-NMDAR encephalitis patients, 30 had a follow-up evaluation at 3 months after admission. <b><i>Results:</i></b> Serum bilirubin and albumin levels were both significantly lower in anti-NMDAR encephalitis than in CTLs, and serum bilirubin levels were significantly lower in anti-NMDAR encephalitis than in cryptococcal encephalitis. Serum bilirubin levels were significantly lower in patients with psychiatric symptoms, with severe impairment, and with limited responses to treatment than those without psychiatric symptoms, with mild impairment, and with favorable responses to treatment, respectively. A follow-up evaluation of 30 patients revealed that the modified Rankin Scale scores were significantly decreased after treatment. Serum bilirubin significantly associated with serum albumin, and plasma hemoglobin. <b><i>Conclusions:</i></b> Our results revealed for the first time an association between the serum levels of bilirubin in the anti-NMDAR encephalitis. Further studies investigating the role of bilirubin and albumin in anti-NMDAR encephalitis are required.
DOI: 10.6084/m9.figshare.7398536
title: Supplementary Material for: Spatial Relationship and Functional Relevance of Three Lipid Domain Populations at the Erythrocyte Surface

description: <b><i>Background/Aims:</i></b> Red blood cells (RBC) have been shown to exhibit stable submicrometric lipid domains enriched in cholesterol (chol), sphingomyelin (SM), phosphatidylcholine (PC) or ganglioside GM1, which represent the four main lipid classes of their outer plasma membrane leaflet. However, whether those lipid domains co-exist at the RBC surface or are spatially related and whether and how they are subjected to reorganization upon RBC deformation are not known. <b><i>Methods:</i></b> Using fluorescence and/or confocal microscopy and well-validated probes, we compared these four lipid-enriched domains for their abundance, curvature association, lipid order, temperature dependence, spatial dissociation and sensitivity to RBC mechanical stimulation. <b><i>Results:</i></b> Our data suggest that three populations of lipid domains with decreasing abundance coexist at the RBC surface: (i) chol-enriched ones, associated with RBC high curvature areas; (ii) GM1/PC/chol-enriched ones, present in low curvature areas; and (iii) SM/PC/chol-enriched ones, also found in low curvature areas. Whereas chol-enriched domains gather in increased curvature areas upon RBC deformation, low curvature-associated lipid domains increase in abundance either upon calcium influx during RBC deformation (GM1/PC/chol-enriched domains) or upon secondary calcium efflux during RBC shape restoration (SM/PC/chol-enriched domains). Hence, abrogation of these two domain populations is accompanied by a strong impairment of the intracellular calcium balance. <b><i>Conclusion:</i></b> Lipid domains could contribute to calcium influx and efflux by controlling the membrane distribution and/or the activity of the mechano-activated ion channel Piezo1 and the calcium pump PMCA. Whether this results from lipid domain biophysical properties, the strength of their anchorage to the underlying cytoskeleton and/or their correspondence with inner plasma membrane leaflet lipids remains to be demonstrated.
DOI: 10.6084/m9.figshare.7398539
title: Supplementary Material for: Peiminine Inhibits Glioblastoma in Vitro and in Vivo Through Cell Cycle Arrest and Autophagic Flux Blocking

description: <b><i>Background/Aims:</i></b> Glioblastoma multiforme (GBM) is the most devastating and widespread primary central nervous system tumour in adults, with poor survival rate and high mortality rates. Existing treatments do not provide substantial benefits to patients; therefore, novel treatment strategies are required. Peiminine, a natural bioactive compound extracted from the traditional Chinese medicine Fritillaria thunbergii, has many pharmacological effects, especially anticancer activities. However, its anticancer effects on GBM and the underlying mechanism have not been demonstrated. This study was conducted to investigate the potential antitumour effects of peiminine in human GBM cells and to explore the related molecular signalling mechanisms<i> in vitro</i> and <i>in vivo</i> <b><i>Methods:</i></b> Cell viability and proliferation were detected with MTT and colony formation assays. Morphological changes associated with autophagy were assessed by transmission electron microscopy (TEM). The cell cycle rate was measured by flow cytometry. To detect changes in related genes and signalling pathways <i>in vitro</i> and <i>in vivo</i>, RNA-seq, Western blotting and immunohistochemical analyses were employed.<b><i> Results:</i></b> Peiminine significantly inhibited the proliferation and colony formation of GBM cells and resulted in changes in many tumour-related genes and transcriptional products. The potential anti-GBM role of peiminine might involve cell cycle arrest and autophagic flux blocking via changes in expression of the cyclin D1/CDK network, p62 and LC3. Changes in Changes in flow cytometry results and TEM findings were also observed. Molecular alterations included downregulation of the expression of not only phospho-Akt and phospho-GSK3β but also phospho-AMPK and phospho-ULK1. Furthermore, overexpression of AKT and inhibition of AKT reversed and augmented peiminine-induced cell cycle arrest in GBM cells, respectively. The cellular activation of AMPK reversed the changes in the levels of protein markers of autophagic flux. These results demonstrated that peiminine mediates cell cycle arrest by suppressing AktGSk3β signalling and blocks autophagic flux by depressing AMPK-ULK1 signalling in GBM cells. Finally, peiminine inhibited the growth of U251 gliomas <i>in vivo</i>.<b><i></i></b> <b><i>Conclusion:</i></b> Peiminine inhibits glioblastoma <i>in vitro</i> and <i>in vivo</i> via arresting the cell cycle and blocking autophagic flux, suggesting new avenues for GBM therapy.
DOI: 10.6084/m9.figshare.7398542
title: Supplementary Material for: miR-155-5p is Negatively Associated with Acute Pancreatitis and Inversely Regulates Pancreatic Acinar Cell Progression by Targeting Rela and Traf3

description: <b><i>Background/Aims:</i></b> Acute pancreatitis contributes to high mortality in pancreatitis patients, and miRNAs play a vital role in the development of acute pancreatitis (AP), however, its precise biological role remains largely elusive. <b><i>Methods:</i></b> To clarify the potential mechanisms of miRNAs in AP, we built mouse models of mild acute pancreatitis (MAP) and moderate/ severe acute pancreatitis (SAP). MiRNA microarray analysis and Real-time quantitative PCR (qRT-PCR) were used to analyze the expression of miRNA in MAP/SAP. TargetScan software, dual-luciferase gene reporter assays and Western blotting were used to assess the target genes of miR-155-5p in AP. <b><i>Results:</i></b> miR-155-5p was significantly decreased in MAP/SAP mice compared to controls. In pancreatic acinar AR42J cells transfected with miR-155-5p mimic, the expression of <i>Rela</i> and <i>Traf3</i> notably decreased in both the caerulein- and TLC-S-induced groups compared with the negative control (NC); however, the expression of <i>Rela</i> and <i>Traf3</i> notably increased after transfection with miR-155-5p inhibitor. Combined analysis using the TargetScan software and dual-luciferase gene reporter assays indicated that <i>Rela</i> and <i>Traf3</i> were both targeted by miR-155-5p. Meanwhile, the expression of <i>Ptgs2</i> also decreased after transfection of the AR42J cells with miR-155-5p mimic. The opposite results were found when miR-155-5p inhibitor was transfected into the AR42J cells. In addition, we treated caerulein- and TLC-S-induced AR42J cells with the <i>Rela</i> inhibitor helenalin and found that the expression of <i>Rela, Traf3</i> and <i>Ptgs2</i> decreased compared with the NC, while the expression of miR-155-5p did not show any significant difference. Furthermore, we found that miR-155-5p was significantly down-regulated in pancreatitis patients. <b><i>Conclusion:</i></b> miR-155-5p inversely regulated AP development through the Rela/Traf3/Ptgs2 signaling pathway.
DOI: 10.7284/119968
title: Radiometer data collected during research cruise OC1405B using a Biospherical QSR-2200 instrument system onboard the platform RV Oceanus

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7398533
title: Natural ligand-nonmimetic inhibitors of the lipid-transfer protein CERT

description: The file set uploaded are Raw data in the research project of "Natural ligand-nonmimetic inhibitors of the lipid-transfer protein CERT", which was published in Communications Chemistry (2019) 2: 20 (doi: 10.1038/s42004-019-0118-3)
DOI: 10.6084/m9.figshare.7398536.v1
title: Supplementary Material for: Spatial Relationship and Functional Relevance of Three Lipid Domain Populations at the Erythrocyte Surface

description: <b><i>Background/Aims:</i></b> Red blood cells (RBC) have been shown to exhibit stable submicrometric lipid domains enriched in cholesterol (chol), sphingomyelin (SM), phosphatidylcholine (PC) or ganglioside GM1, which represent the four main lipid classes of their outer plasma membrane leaflet. However, whether those lipid domains co-exist at the RBC surface or are spatially related and whether and how they are subjected to reorganization upon RBC deformation are not known. <b><i>Methods:</i></b> Using fluorescence and/or confocal microscopy and well-validated probes, we compared these four lipid-enriched domains for their abundance, curvature association, lipid order, temperature dependence, spatial dissociation and sensitivity to RBC mechanical stimulation. <b><i>Results:</i></b> Our data suggest that three populations of lipid domains with decreasing abundance coexist at the RBC surface: (i) chol-enriched ones, associated with RBC high curvature areas; (ii) GM1/PC/chol-enriched ones, present in low curvature areas; and (iii) SM/PC/chol-enriched ones, also found in low curvature areas. Whereas chol-enriched domains gather in increased curvature areas upon RBC deformation, low curvature-associated lipid domains increase in abundance either upon calcium influx during RBC deformation (GM1/PC/chol-enriched domains) or upon secondary calcium efflux during RBC shape restoration (SM/PC/chol-enriched domains). Hence, abrogation of these two domain populations is accompanied by a strong impairment of the intracellular calcium balance. <b><i>Conclusion:</i></b> Lipid domains could contribute to calcium influx and efflux by controlling the membrane distribution and/or the activity of the mechano-activated ion channel Piezo1 and the calcium pump PMCA. Whether this results from lipid domain biophysical properties, the strength of their anchorage to the underlying cytoskeleton and/or their correspondence with inner plasma membrane leaflet lipids remains to be demonstrated.
DOI: 10.6084/m9.figshare.7398542.v1
title: Supplementary Material for: miR-155-5p is Negatively Associated with Acute Pancreatitis and Inversely Regulates Pancreatic Acinar Cell Progression by Targeting Rela and Traf3

description: <b><i>Background/Aims:</i></b> Acute pancreatitis contributes to high mortality in pancreatitis patients, and miRNAs play a vital role in the development of acute pancreatitis (AP), however, its precise biological role remains largely elusive. <b><i>Methods:</i></b> To clarify the potential mechanisms of miRNAs in AP, we built mouse models of mild acute pancreatitis (MAP) and moderate/ severe acute pancreatitis (SAP). MiRNA microarray analysis and Real-time quantitative PCR (qRT-PCR) were used to analyze the expression of miRNA in MAP/SAP. TargetScan software, dual-luciferase gene reporter assays and Western blotting were used to assess the target genes of miR-155-5p in AP. <b><i>Results:</i></b> miR-155-5p was significantly decreased in MAP/SAP mice compared to controls. In pancreatic acinar AR42J cells transfected with miR-155-5p mimic, the expression of <i>Rela</i> and <i>Traf3</i> notably decreased in both the caerulein- and TLC-S-induced groups compared with the negative control (NC); however, the expression of <i>Rela</i> and <i>Traf3</i> notably increased after transfection with miR-155-5p inhibitor. Combined analysis using the TargetScan software and dual-luciferase gene reporter assays indicated that <i>Rela</i> and <i>Traf3</i> were both targeted by miR-155-5p. Meanwhile, the expression of <i>Ptgs2</i> also decreased after transfection of the AR42J cells with miR-155-5p mimic. The opposite results were found when miR-155-5p inhibitor was transfected into the AR42J cells. In addition, we treated caerulein- and TLC-S-induced AR42J cells with the <i>Rela</i> inhibitor helenalin and found that the expression of <i>Rela, Traf3</i> and <i>Ptgs2</i> decreased compared with the NC, while the expression of miR-155-5p did not show any significant difference. Furthermore, we found that miR-155-5p was significantly down-regulated in pancreatitis patients. <b><i>Conclusion:</i></b> miR-155-5p inversely regulated AP development through the Rela/Traf3/Ptgs2 signaling pathway.