cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.5777583.v2
title: Residual symptoms and disease burden among patients with rheumatoid arthritis in remission or low disease activity: a systematic literature review

description: <b>Objectives:</b> To identify, describe and summarize evidence on residual symptoms and disease burdens in rheumatoid arthritis (RA) patients qualified as being in remission or low disease activity (LDA). <b>Methods:</b> A systematic literature review (SLR) was conducted according to Cochrane collaboration guidelines. The population of interest was adult patients with RA in remission or LDA. The reported outcomes of interest were any symptoms or burdens. <b>Results:</b> Fifty-one publications were identified through an eDatabase search. Together with 17 articles found through other sources, 68 were included for full text review. The most commonly reported residual symptoms were pain (number of studies = 25), fatigue (<i>n</i> = 21) and morning stiffness (<i>n</i> = 5). Reported disease burdens included mental health (<i>n</i> = 15), sleep disturbances (<i>n</i> = 7) and work productivity (<i>n</i> = 5), impairment in quality of life (<i>n</i> = 21), and functional disability (<i>n</i> = 34). Substantial residual symptoms and disease burdens were found to be present in patients in remission or LDA. <b>Conclusion:</b> This is the first SLR to investigate residual symptoms and disease burdens in RA patients in remission or LDA. The results indicate that despite achieving conventional clinical targets, the disease continues to affect patients, suggesting the existence of unmet need under the current treatment paradigm.
DOI: 10.6084/m9.figshare.5777583.v1
title: Residual symptoms and disease burden among patients with rheumatoid arthritis in remission or low disease activity: a systematic literature review

description: <b>Objectives:</b> To identify, describe and summarize evidence on residual symptoms and disease burdens in rheumatoid arthritis (RA) patients qualified as being in remission or low disease activity (LDA). <b>Methods:</b> A systematic literature review (SLR) was conducted according to Cochrane collaboration guidelines. The population of interest was adult patients with RA in remission or LDA. The reported outcomes of interest were any symptoms or burdens. <b>Results:</b> Fifty-one publications were identified through an eDatabase search. Together with 17 articles found through other sources, 68 were included for full text review. The most commonly reported residual symptoms were pain (number of studies = 25), fatigue (<i>n</i> = 21) and morning stiffness (<i>n</i> = 5). Reported disease burdens included mental health (<i>n</i> = 15), sleep disturbances (<i>n</i> = 7) and work productivity (<i>n</i> = 5), impairment in quality of life (<i>n</i> = 21), and functional disability (<i>n</i> = 34). Substantial residual symptoms and disease burdens were found to be present in patients in remission or LDA. <b>Conclusion:</b> This is the first SLR to investigate residual symptoms and disease burdens in RA patients in remission or LDA. The results indicate that despite achieving conventional clinical targets, the disease continues to affect patients, suggesting the existence of unmet need under the current treatment paradigm.
DOI: 10.6084/m9.figshare.5777550
title: Data for Chemical defence of toad tadpoles under risk by four predator species

description: Data file for "Chemical defence of toad tadpoles under risk by four predator species" (Ecology and Evolution, doi: 10.1002/ece3.5202). The data contains two worksheets, one dataset for the analysis of bufadienolide toxins of common toad (<i>Bufo bufo</i>) and one dataset for the predation trials. <br>
DOI: 10.6084/m9.figshare.5777550.v1
title: Data for Chemical defence of toad tadpoles under risk by four predator species

description: Data file for "Chemical defence of toad tadpoles under risk by four predator species" (Ecology and Evolution, doi: 10.1002/ece3.5202). The data contains two worksheets, one dataset for the analysis of bufadienolide toxins of common toad (<i>Bufo bufo</i>) and one dataset for the predation trials. <br>
DOI: 10.6084/m9.figshare.5777532
title: Functional traits and environmental characteristics drive the degree of competitive intransitivity in European salt marsh plant communities

description: Raw data set accompanying a publication in the Journal of Ecology on the competitive structure of salt marsh plant communities.
DOI: 10.6084/m9.figshare.5777532.v1
title: Functional traits and environmental characteristics drive the degree of competitive intransitivity in European salt marsh plant communities

description: Raw data set accompanying a publication in the Journal of Ecology on the competitive structure of salt marsh plant communities.
DOI: 10.6084/m9.figshare.5777508
title: Supplementary Data from Phanerozoic <i>p</i>O<sub>2</sub> and the early evolution of terrestrial animals

description: Concurrent gaps in the Late Devonian/Mississippian fossil records of insects and tetrapods (i.e. Romer's Gap) have been attributed to physiological suppression by low atmospheric <i>p</i>O<sub>2</sub>. Here, updated stable isotope inputs inform a reconstruction of Phanerozoic oxygen levels that contradicts the low oxygen hypothesis (and contradicts the purported role of oxygen in the evolution of gigantic insects during the Late Palaeozoic), but reconciles isotope-based calculations with other proxies, like charcoal. Furthermore, statistical analysis demonstrates that the gap between the first Devonian insect and earliest diverse insect assemblages of the Pennsylvanian (Bashkirian Stage) requires no special explanation if insects were neither diverse nor abundant prior to the evolution of wings. Rather than tracking physiological constraint, the fossil record may accurately record the transformative evolutionary impact of insect flight.
DOI: 10.6084/m9.figshare.5777508.v1
title: Supplementary Data from Phanerozoic <i>p</i>O<sub>2</sub> and the early evolution of terrestrial animals

description: Concurrent gaps in the Late Devonian/Mississippian fossil records of insects and tetrapods (i.e. Romer's Gap) have been attributed to physiological suppression by low atmospheric <i>p</i>O<sub>2</sub>. Here, updated stable isotope inputs inform a reconstruction of Phanerozoic oxygen levels that contradicts the low oxygen hypothesis (and contradicts the purported role of oxygen in the evolution of gigantic insects during the Late Palaeozoic), but reconciles isotope-based calculations with other proxies, like charcoal. Furthermore, statistical analysis demonstrates that the gap between the first Devonian insect and earliest diverse insect assemblages of the Pennsylvanian (Bashkirian Stage) requires no special explanation if insects were neither diverse nor abundant prior to the evolution of wings. Rather than tracking physiological constraint, the fossil record may accurately record the transformative evolutionary impact of insect flight.
DOI: 10.6084/m9.figshare.5777472
title: Cold adaptation of tRNA nucleotidyltransferases: A tradeoff in activity, stability and fidelity

description: Cold adaptation is an evolutionary process that has dramatic impact on enzymatic activity. Increased flexibility of the protein structure represents the main evolutionary strategy for efficient catalysis and reaction rates in the cold, but is achieved at the expense of structural stability. This results in a significant activity-stability tradeoff, as it was observed for several metabolic enzymes. In polymerases, however, not only reaction rates, but also fidelity plays an important role, as these enzymes have to synthesize copies of DNA and RNA as exact as possible. Here, we investigate the effects of cold adaptation on the highly accurate CCA-adding enzyme, an RNA polymerase that uses an internal amino acid motif within the flexible catalytic core as a template to synthesize the CCA triplet at tRNA 3′-ends. As the relative orientation of these residues determines nucleotide selection, we characterized how cold adaptation impacts template reading and fidelity. In a comparative analysis of closely related psychro-, meso-, and thermophilic enzymes, the cold-adapted polymerase shows a remarkable error rate during CCA synthesis <i>in vitro</i> as well as <i>in vivo</i>. Accordingly, CCA-adding activity at low temperatures is not only achieved at the expense of structural stability, but also results in a reduced polymerization fidelity.
DOI: 10.6084/m9.figshare.5777430
title: Moricandia moricandioides' floral display

description: Data set describing the advertising effort of Moricandia moricandioides plants grown in glasshouse under different intra-specific social environments. Two files: DATA_INDIVIDUALS.txt includes data for each focal individual, while DATA_FLOWERS.txt includes data at flower level, so each row is a different flower.<br>
DOI: 10.6084/m9.figshare.5777430.v1
title: Moricandia moricandioides' floral display

description: Data set describing the advertising effort of Moricandia moricandioides plants grown in glasshouse under different intra-specific social environments. Two files: DATA_INDIVIDUALS.txt includes data for each focal individual, while DATA_FLOWERS.txt includes data at flower level, so each row is a different flower.<br>
DOI: 10.6084/m9.figshare.5777412
title: Supplementary Material for: Adjudication of Transient Ischemic Attack and Stroke in the Multi-Ethnic Study of Atherosclerosis

description: <b><i>Background:</i></b> To describe adjudication of transient ischemic attack (TIA) and stroke in an observational study. <b><i>Methods:</i></b> We detail the process used to adjudicate TIA and stroke in the Multi-Ethnic Study of Atherosclerosis (MESA), a large longitudinal cohort study. Two of three vascular neurologists adjudicated each event using specific protocols. We examined the initial agreement, effect of imaging on diagnosis of TIA versus ischemic stroke, and effect of strict and less strict criteria on the number of ischemic stroke subtypes classified as undetermined. <b><i>Results:</i></b> Of 573 adjudicated events over 13.5 years of follow-up, 95 (16.5%) had TIA and 269 (47.0%) had stroke: 211 (78.4%) ischemic, 43 (16.0%) hemorrhagic, and 15 (5.6%) other. Disagreements occurred on 16% of initial adjudication of events. Using results from imaging, the number with TIA decreased by 8.6% and with ischemic stroke increased by 4.1%. Using less strict criteria to classify ischemic stroke subtypes reduced the number classified as undetermined, from 137 to 59, and numbers classified as cardioembolic and small vessel doubled. <b><i>Conclusions:</i></b> We hope that this work will motivate and facilitate investigators to use MESA data to investigate issues concerning TIA and stroke and will inform investigators seeking to adjudicate TIA and stroke in other studies.
DOI: 10.6084/m9.figshare.5777412.v1
title: Supplementary Material for: Adjudication of Transient Ischemic Attack and Stroke in the Multi-Ethnic Study of Atherosclerosis

description: <b><i>Background:</i></b> To describe adjudication of transient ischemic attack (TIA) and stroke in an observational study. <b><i>Methods:</i></b> We detail the process used to adjudicate TIA and stroke in the Multi-Ethnic Study of Atherosclerosis (MESA), a large longitudinal cohort study. Two of three vascular neurologists adjudicated each event using specific protocols. We examined the initial agreement, effect of imaging on diagnosis of TIA versus ischemic stroke, and effect of strict and less strict criteria on the number of ischemic stroke subtypes classified as undetermined. <b><i>Results:</i></b> Of 573 adjudicated events over 13.5 years of follow-up, 95 (16.5%) had TIA and 269 (47.0%) had stroke: 211 (78.4%) ischemic, 43 (16.0%) hemorrhagic, and 15 (5.6%) other. Disagreements occurred on 16% of initial adjudication of events. Using results from imaging, the number with TIA decreased by 8.6% and with ischemic stroke increased by 4.1%. Using less strict criteria to classify ischemic stroke subtypes reduced the number classified as undetermined, from 137 to 59, and numbers classified as cardioembolic and small vessel doubled. <b><i>Conclusions:</i></b> We hope that this work will motivate and facilitate investigators to use MESA data to investigate issues concerning TIA and stroke and will inform investigators seeking to adjudicate TIA and stroke in other studies.
DOI: 10.6084/m9.figshare.5777400
title: The stability of Malathion in Representative Fruits and Vegetables

description: pesticides residue storage stability
DOI: 10.6084/m9.figshare.5777400.v1
title: The stability of Malathion in Representative Fruits and Vegetables

description: pesticides residue storage stability
DOI: 10.6084/m9.figshare.5777397
title: 人民日报语料.txt

description: This is peoples' daily corpus of 1998 year published by Peking University.
DOI: 10.6084/m9.figshare.5777391
title: The stability of organophosphorus pesticides in peanut and soybean extracting solutions

description: TABLE 123 are about stability of organophosphorus pesticides in peanut and soybean extracting solutions.FIG 1 is GC chromatagraph.
DOI: 10.6084/m9.figshare.5777391.v1
title: The stability of organophosphorus pesticides in peanut and soybean extracting solutions

description: TABLE 123 are about stability of organophosphorus pesticides in peanut and soybean extracting solutions.FIG 1 is GC chromatagraph.
DOI: 10.6084/m9.figshare.5777376
title: Taxonomic diversity masks leaf vein–climate relationships: lessons from herbarium collections across a latitudinal rainfall gradient in West Africa

description: Cross-biome data suggest that leaf venation density increases with decreasing moisture availability. If leaf venation traits were related to climatic conditions in such a predictable manner, these traits could serve, for example, as proxies for the reconstruction of past climates from fossil leaf remnants. However, our knowledge on vein–climate relationships is still scarce and relationships are poorly understood, particularly concerning broad-scale patterns in tropical regions. In this study, based on phylogenetic generalized least squares regression, we analysed leaf venation traits together with climatic niche data from 238 herbarium specimens to infer trait–trait and trait–climate relationships along a strong north–south rainfall gradient crossing West African savannas. Variation in leaf venation traits was strong along the climate gradient, yet vein–climate relationships were weak overall. This is in contrast to our expectation from the strong adaptive forces operating in drought-adapted vegetation covered by the gradient. On the other hand, several common patterns including intervein and vein–leaf size relationships were confirmed. A key finding was that while trait–climate relationships were mostly weak, some of these relationships became stronger when breaking down the entire taxon assemblage into smaller family-level units. This suggests that vein traits underlie partially opposing constraints in different clades, a pattern that is likely to become stronger with increasing higher-rank taxonomic diversity of species assemblages.
DOI: 10.6084/m9.figshare.5777376.v1
title: Taxonomic diversity masks leaf vein–climate relationships: lessons from herbarium collections across a latitudinal rainfall gradient in West Africa

description: Cross-biome data suggest that leaf venation density increases with decreasing moisture availability. If leaf venation traits were related to climatic conditions in such a predictable manner, these traits could serve, for example, as proxies for the reconstruction of past climates from fossil leaf remnants. However, our knowledge on vein–climate relationships is still scarce and relationships are poorly understood, particularly concerning broad-scale patterns in tropical regions. In this study, based on phylogenetic generalized least squares regression, we analysed leaf venation traits together with climatic niche data from 238 herbarium specimens to infer trait–trait and trait–climate relationships along a strong north–south rainfall gradient crossing West African savannas. Variation in leaf venation traits was strong along the climate gradient, yet vein–climate relationships were weak overall. This is in contrast to our expectation from the strong adaptive forces operating in drought-adapted vegetation covered by the gradient. On the other hand, several common patterns including intervein and vein–leaf size relationships were confirmed. A key finding was that while trait–climate relationships were mostly weak, some of these relationships became stronger when breaking down the entire taxon assemblage into smaller family-level units. This suggests that vein traits underlie partially opposing constraints in different clades, a pattern that is likely to become stronger with increasing higher-rank taxonomic diversity of species assemblages.
DOI: 10.6084/m9.figshare.5777301
title: Additional file 4: Table S3. of A prototypical non-malignant epithelial model to study genome dynamics and concurrently monitor micro-RNAs and proteins in situ during oncogene-induced senescence

description: Genes triggering oncogene-induced senescence. (XLSX 12Â kb)
DOI: 10.6084/m9.figshare.5777301.v1
title: Additional file 4: Table S3. of A prototypical non-malignant epithelial model to study genome dynamics and concurrently monitor micro-RNAs and proteins in situ during oncogene-induced senescence

description: Genes triggering oncogene-induced senescence. (XLSX 12Â kb)
DOI: 10.6084/m9.figshare.5777292
title: Additional file 3: Table S2. of A prototypical non-malignant epithelial model to study genome dynamics and concurrently monitor micro-RNAs and proteins in situ during oncogene-induced senescence

description: Studies on miR expression in senescent cells. (XLSX 20Â kb)
DOI: 10.6084/m9.figshare.5777292.v1
title: Additional file 3: Table S2. of A prototypical non-malignant epithelial model to study genome dynamics and concurrently monitor micro-RNAs and proteins in situ during oncogene-induced senescence

description: Studies on miR expression in senescent cells. (XLSX 20Â kb)
DOI: 10.6084/m9.figshare.5777277
title: Additional file 2: Table S1. of A prototypical non-malignant epithelial model to study genome dynamics and concurrently monitor micro-RNAs and proteins in situ during oncogene-induced senescence

description: Subcellular localization of miRs. (XLSX 12Â kb)
DOI: 10.6084/m9.figshare.5777277.v1
title: Additional file 2: Table S1. of A prototypical non-malignant epithelial model to study genome dynamics and concurrently monitor micro-RNAs and proteins in situ during oncogene-induced senescence

description: Subcellular localization of miRs. (XLSX 12Â kb)
DOI: 10.6084/m9.figshare.5777256
title: Additional file 6: of Healthy apple program to support child care centers to alter nutrition and physical activity practices and improve child weight: a cluster randomized trial

description: HAP Pilot de-identified analysis file. This de-identified dataset includes the variables used for the reported analyses. The variables included were: Age- and sex-specific BMI percentile; BMI z-score; Intention-to-treat group assignment (springitts); Age in years; Sex (male = 1; female = 0), Dichotomous indicator of weight status at the Autumn screening (1 = BMI &gt; = 85th percentile, 0: BMI
DOI: 10.6084/m9.figshare.5777256.v1
title: Additional file 6: of Healthy apple program to support child care centers to alter nutrition and physical activity practices and improve child weight: a cluster randomized trial

description: HAP Pilot de-identified analysis file. This de-identified dataset includes the variables used for the reported analyses. The variables included were: Age- and sex-specific BMI percentile; BMI z-score; Intention-to-treat group assignment (springitts); Age in years; Sex (male = 1; female = 0), Dichotomous indicator of weight status at the Autumn screening (1 = BMI &gt; = 85th percentile, 0: BMI
DOI: 10.6084/m9.figshare.12894944
title: R0189_20171011a_videos

description: Rat 0189, skilled reaching data collected in Leventhal laboratory by Alexandra Bova
DOI: 10.6084/m9.figshare.12894944.v1
title: R0189_20171011a_videos

description: Rat 0189, skilled reaching data collected in Leventhal laboratory by Alexandra Bova
DOI: 10.6084/m9.figshare.12895127
title: Gene database of Thermococcus kodakarensis KOD1

description: <i>Thermococcus kodakarensis</i> is a thermophilic archaeon whose repertoire of thermostable enzymes have found use in industrial biotechnology applications. Capable of surviving at high temperatures of 80 to 95 <sup>o</sup>C, the archaeon’s growth is also stimulated by elemental sulphur. More importantly, the archaeon is an obligate heterotroph capable of fermenting a variety of organic compounds such as peptides, amino acids, and sugars in the absence of sulphur. This work sought to provide fundamental information about the genetic repertoire of <i>T. kodakarensis </i>KOD1 by parsing its annotated genome sequence downloaded from Genbank. Comprising gene name, gene function, and gene sequence, the database should find use in a variety of fundamental and applied biology workflows such as profiling useful enzymes from the archaeon, as well as cloning candidate genes into other expression hosts.
DOI: 10.6084/m9.figshare.5777199
title: Additional file 16: Table S7. of A prototypical non-malignant epithelial model to study genome dynamics and concurrently monitor micro-RNAs and proteins in situ during oncogene-induced senescence

description: MiR enrichment analysis showing pathways, Gene Ontology terms and Target genes significantly linked to differentially-expressed miRs between respective groups.Fields marked out in bold represent pathways present in at least two pairwise comparisons. (XLSX 20Â kb)
DOI: 10.6084/m9.figshare.5777199.v1
title: Additional file 16: Table S7. of A prototypical non-malignant epithelial model to study genome dynamics and concurrently monitor micro-RNAs and proteins in situ during oncogene-induced senescence

description: MiR enrichment analysis showing pathways, Gene Ontology terms and Target genes significantly linked to differentially-expressed miRs between respective groups.Fields marked out in bold represent pathways present in at least two pairwise comparisons. (XLSX 20Â kb)
DOI: 10.6084/m9.figshare.5777175
title: Additional file 15: Table S6. of A prototypical non-malignant epithelial model to study genome dynamics and concurrently monitor micro-RNAs and proteins in situ during oncogene-induced senescence

description: Potential miR signature of senescence according to miRseq analysis of HBEC CDC6 Tet-ON system and existing literature. (XLSX 9Â kb)
DOI: 10.6084/m9.figshare.5777175.v1
title: Additional file 15: Table S6. of A prototypical non-malignant epithelial model to study genome dynamics and concurrently monitor micro-RNAs and proteins in situ during oncogene-induced senescence

description: Potential miR signature of senescence according to miRseq analysis of HBEC CDC6 Tet-ON system and existing literature. (XLSX 9Â kb)
DOI: 10.6084/m9.figshare.5777133
title: Additional file 13: Table S5. of A prototypical non-malignant epithelial model to study genome dynamics and concurrently monitor micro-RNAs and proteins in situ during oncogene-induced senescence

description: A MiR expression differences between induced (3d ON) and non-induced (OFF) HBEC CDC6 Tet-ON cells. FWER - Bonferroni-adjusted p value. b MiR expression differences between induced (6d ON) and non-induced (OFF) HBEC CDC6 Tet-ON cells. FWER - Bonferroni-adjusted p value. c MiR expression differences between "escaped" (ESC) and non-induced (OFF) HBEC CDC6 Tet-ON cells. FWER - Bonferroni-adjusted p value. d MiR expression differences between 3-day induced (3d ON) and 6-day induced (6d ON) HBEC CDC6 Tet-ON cells. FWER - Bonferroni-adjusted p value. e MiR expression differences between "escaped" (ESC) and induced (3d ON) HBEC CDC6 Tet-ON cells. FWER - Bonferroni-adjusted p value. f MiR expression differences between "escaped" (ESC) and induced (6d ON) HBEC CDC6 Tet-ON cells. FWER - Bonferroni-adjusted p value. (XLSX 134 kb)