cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.20522940
title: Self-reported and objective sleep duration in patients with CKD: are they telling the same story?

description: Abstract Introduction: There is disagreement between data on sleep duration obtained from questionnaires and objective measurements. Whether this is also true for individuals with CKD is unknown. Here we compared self-reported sleep duration with sleep duration obtained by actigraphy. Methods: This prospective study included adult individuals with stage 3 CKD recruited between September/2016 and February/2019. We evaluated subjective sleep duration by asking the following question: “How many hours of actual sleep did you get at night?” Results: Patients (N=34) were relatively young (51 ± 13 years). Self-reported and measured sleep duration were 7.1 ± 1.7 and 6.9 ± 1.6 hours, respectively, with no correlation between them (p=0.165). Although the mean difference between measurements was 0.21 h, the limits of agreement ranged from -3.7 to 4.1 h. Conclusion: Patients with CKD who are not on dialysis have an erroneous sleep perception. Data on sleep duration should be preferentially obtained from objective measurements in patients with CKD.
DOI: 10.6084/m9.figshare.20522940.v1
title: Self-reported and objective sleep duration in patients with CKD: are they telling the same story?

description: Abstract Introduction: There is disagreement between data on sleep duration obtained from questionnaires and objective measurements. Whether this is also true for individuals with CKD is unknown. Here we compared self-reported sleep duration with sleep duration obtained by actigraphy. Methods: This prospective study included adult individuals with stage 3 CKD recruited between September/2016 and February/2019. We evaluated subjective sleep duration by asking the following question: “How many hours of actual sleep did you get at night?” Results: Patients (N=34) were relatively young (51 ± 13 years). Self-reported and measured sleep duration were 7.1 ± 1.7 and 6.9 ± 1.6 hours, respectively, with no correlation between them (p=0.165). Although the mean difference between measurements was 0.21 h, the limits of agreement ranged from -3.7 to 4.1 h. Conclusion: Patients with CKD who are not on dialysis have an erroneous sleep perception. Data on sleep duration should be preferentially obtained from objective measurements in patients with CKD.
DOI: 10.6084/m9.figshare.20847166
title: Sacrococcygeal teratoma: evaluation of its approach, treatment and follow-up in two reference children cancer centers in Brazil / Rio de Janeiro

description: ABSTRACT Introduction: sacrococcygeal teratoma (TSC) is the most common tumor of the neonatal period. Alphafetoprotein is an important tumor marker and is used in the follow-up period as a marker of malignancy. The complete surgical resection of the tumor associated with coccygectomy is the standard treatment and chemotherapy in different stages are necessary. Follow-up consists of serial exam: tumor markers, imaging searching to possible metastasis sites, in addition to a complete physical examination. Methodology: a descriptive, retrospective, study was carried out by analyzing a chart of 25 patients of two different reference children cancer center; with TSC in the State of Rio de Janeiro from 2004 to 2019. The clinical and epidemiological data collected were described and a comparison was made between these two centers studied. Results: the sociodemographic characteristics found were similar to those described in the medical literature. Data related to treatment and follow-up, such as the use of chemotherapy, use of specific imaging tests, digital rectal examination, and outpatient follow-up, differed between the two centers studied. There was a 25% loss of follow-up. Conclusion: the characteristic of being a non-cancer center can interfere with the full application of the current protocol for the treatment of sacrococcygeal teratoma. The knowledge of the data of the studied cases can allow the optimization of the approach of the patients with this pathology and generate discussions about the integral application of the specific therapeutic protocol in the medical centers that are qualified for such treatment.
DOI: 10.6084/m9.figshare.20847166.v1
title: Sacrococcygeal teratoma: evaluation of its approach, treatment and follow-up in two reference children cancer centers in Brazil / Rio de Janeiro

description: ABSTRACT Introduction: sacrococcygeal teratoma (TSC) is the most common tumor of the neonatal period. Alphafetoprotein is an important tumor marker and is used in the follow-up period as a marker of malignancy. The complete surgical resection of the tumor associated with coccygectomy is the standard treatment and chemotherapy in different stages are necessary. Follow-up consists of serial exam: tumor markers, imaging searching to possible metastasis sites, in addition to a complete physical examination. Methodology: a descriptive, retrospective, study was carried out by analyzing a chart of 25 patients of two different reference children cancer center; with TSC in the State of Rio de Janeiro from 2004 to 2019. The clinical and epidemiological data collected were described and a comparison was made between these two centers studied. Results: the sociodemographic characteristics found were similar to those described in the medical literature. Data related to treatment and follow-up, such as the use of chemotherapy, use of specific imaging tests, digital rectal examination, and outpatient follow-up, differed between the two centers studied. There was a 25% loss of follow-up. Conclusion: the characteristic of being a non-cancer center can interfere with the full application of the current protocol for the treatment of sacrococcygeal teratoma. The knowledge of the data of the studied cases can allow the optimization of the approach of the patients with this pathology and generate discussions about the integral application of the specific therapeutic protocol in the medical centers that are qualified for such treatment.
DOI: 10.6084/m9.figshare.20847162
title: Synthesis and characterization of chitosan-PVA hydrogel containing PEGylated recombinant epidermal growth factor on cell culture for wound healing substitute

description: Abstract The aim of the current study was to assess the physicochemical characteristics and wound healing activity of chitosan-polyvinyl alcohol (PVA) crosslinked hydrogel containing recombinant human epidermal growth factor (rh-EGF) or recombinant mouse epidermal growth factor (rm-EGF). The hydrogels were prepared and analyses were made of the morphological properties, viscosity, water absorption capacity, mechanical and bio-adhesive properties. The viscosity of the formulations varied between 14.400 - 48.500 cPs, with the greatest viscosity values determined in K2 formulation. F2 formulation showed the highest water absorption capacity. According to the studies of the mechanical properties, H2 formulation (0.153±0.018 N.mm) showed the greatest adhesiveness and E2 (0.245±0.001 mj/cm2) formulation, the highest bio-adhesion values. Hydrogels were cytocompatible considering in vitro cell viability values of over 76% on human keratinocyte cells (HaCaT, CVCL-0038) and of over 84% on human fibroblast cells (NIH 3T3, CRL-1658) used as a model cell line. According to the BrdU cell proliferation results, B1 (197.82±2.48%) formulation showed the greatest NIH 3T3 and C1 (167.43±5.89%) formulation exhibited the highest HaCaT cell proliferation ability. In addition, the scratch closure assay was performed to assess the wound healing efficiency of formulation and the results obtained in the study showed that F2 formulation including PEGylated rh-EGF had a highly effective role.
DOI: 10.6084/m9.figshare.20847162.v1
title: Synthesis and characterization of chitosan-PVA hydrogel containing PEGylated recombinant epidermal growth factor on cell culture for wound healing substitute

description: Abstract The aim of the current study was to assess the physicochemical characteristics and wound healing activity of chitosan-polyvinyl alcohol (PVA) crosslinked hydrogel containing recombinant human epidermal growth factor (rh-EGF) or recombinant mouse epidermal growth factor (rm-EGF). The hydrogels were prepared and analyses were made of the morphological properties, viscosity, water absorption capacity, mechanical and bio-adhesive properties. The viscosity of the formulations varied between 14.400 - 48.500 cPs, with the greatest viscosity values determined in K2 formulation. F2 formulation showed the highest water absorption capacity. According to the studies of the mechanical properties, H2 formulation (0.153±0.018 N.mm) showed the greatest adhesiveness and E2 (0.245±0.001 mj/cm2) formulation, the highest bio-adhesion values. Hydrogels were cytocompatible considering in vitro cell viability values of over 76% on human keratinocyte cells (HaCaT, CVCL-0038) and of over 84% on human fibroblast cells (NIH 3T3, CRL-1658) used as a model cell line. According to the BrdU cell proliferation results, B1 (197.82±2.48%) formulation showed the greatest NIH 3T3 and C1 (167.43±5.89%) formulation exhibited the highest HaCaT cell proliferation ability. In addition, the scratch closure assay was performed to assess the wound healing efficiency of formulation and the results obtained in the study showed that F2 formulation including PEGylated rh-EGF had a highly effective role.
DOI: 10.6084/m9.figshare.20847177.v1
title: Mapping of Research on Spanish for Specific Purposes in the Context of Brazilian Postgraduate Studies

description: Abstract Research on Spanish for specific purposes area in Brazil gained greater prominence in academic realm from the 2000s onwards. Historically, the greatest amount of studies, since the arising of a national project which demarcated the beginning of languages for specific purposes area, included theoretical, professional, and academic studies in contexts that were primarily related to the teaching of English, French and Portuguese languages. Given the lack and late development of investigations that would promote articulation between teaching of Spanish and specific purposes area, we outline as an objective for this article the mapping of Spanish academic studies produced in Brazilian postgraduate programs and how these works demonstrate the paths, theoretical perspectives, and challenges for this scientific field.
DOI: 10.6084/m9.figshare.20847177
title: Mapping of Research on Spanish for Specific Purposes in the Context of Brazilian Postgraduate Studies

description: Abstract Research on Spanish for specific purposes area in Brazil gained greater prominence in academic realm from the 2000s onwards. Historically, the greatest amount of studies, since the arising of a national project which demarcated the beginning of languages for specific purposes area, included theoretical, professional, and academic studies in contexts that were primarily related to the teaching of English, French and Portuguese languages. Given the lack and late development of investigations that would promote articulation between teaching of Spanish and specific purposes area, we outline as an objective for this article the mapping of Spanish academic studies produced in Brazilian postgraduate programs and how these works demonstrate the paths, theoretical perspectives, and challenges for this scientific field.
DOI: 10.6084/m9.figshare.20847184
title: Quality Management Systems: correlation study between leadership and maturity

description: abstract: Leadership is a key element of quality management, and, as such, it has been identified as an influential factor in the maturity of quality management systems (QMSs). Some of the previous studies on the relationship between leadership styles and QMS performance have argued that no universal best leadership style exists, stressing that leadership practices should be appropriate to the context. Thus, this research aims to further explore this relationship by considering the QMS context, namely the practitioners' leadership profile and the QMS maturity. Accordingly, the primary objectives of this study are 1) to understand if a leadership style is predominant depending on the QMS maturity and 2) to understand the relationship between the leadership practices of different styles and the dimensions of the QMS maturity. An exploratory quantitative study was developed in companies located in Portugal through a survey based on the maturity model developed by Nascimento et al. (2016) and the Multifactor Leadership Questionnaire®-5X Short Leader Form MLQ of Avolio and Bass (1995). The diagnosis disclosed that only 32% of the sample had a QMS with higher maturity levels (4 and 5, a scale of 1 to 5). The results highlighted that no single leadership style dominates a specific maturity level. Furthermore, a significant positive correlation was demonstrated between several practices of transformational and transactional leadership styles and the dimensions of QMS maturity. As a practical contribution, a guideline was provided with some examples of leadership practices and their impacts on the specific dimensions of QMS maturity. Some steps were also proposed to enable organisations to develop a tailored programme to foster leadership practices suitable to the internal context and promote QMS maturity.
DOI: 10.6084/m9.figshare.20847184.v1
title: Quality Management Systems: correlation study between leadership and maturity

description: abstract: Leadership is a key element of quality management, and, as such, it has been identified as an influential factor in the maturity of quality management systems (QMSs). Some of the previous studies on the relationship between leadership styles and QMS performance have argued that no universal best leadership style exists, stressing that leadership practices should be appropriate to the context. Thus, this research aims to further explore this relationship by considering the QMS context, namely the practitioners' leadership profile and the QMS maturity. Accordingly, the primary objectives of this study are 1) to understand if a leadership style is predominant depending on the QMS maturity and 2) to understand the relationship between the leadership practices of different styles and the dimensions of the QMS maturity. An exploratory quantitative study was developed in companies located in Portugal through a survey based on the maturity model developed by Nascimento et al. (2016) and the Multifactor Leadership Questionnaire®-5X Short Leader Form MLQ of Avolio and Bass (1995). The diagnosis disclosed that only 32% of the sample had a QMS with higher maturity levels (4 and 5, a scale of 1 to 5). The results highlighted that no single leadership style dominates a specific maturity level. Furthermore, a significant positive correlation was demonstrated between several practices of transformational and transactional leadership styles and the dimensions of QMS maturity. As a practical contribution, a guideline was provided with some examples of leadership practices and their impacts on the specific dimensions of QMS maturity. Some steps were also proposed to enable organisations to develop a tailored programme to foster leadership practices suitable to the internal context and promote QMS maturity.
DOI: 10.6084/m9.figshare.20847189
title: Cartography as a Research Method for Work and Subjectivity Studies

description: ABSTRACT Objective: the study aims to present cartography as a suitable method to research work and subjectivity in administration. Proposal: in this article, cartography is supported by Deleuze and Guattari’s concept of ‘rhizome,’ aligned to post-structuralism and grounded on administration studies. Finally, this study proposes the flâneur-cartographer as a cross-cutting practice in research. The use of cartography is illustrated by describing the cartographic path of a study on subjectivation processes that make up the immaterial labor of migrants and refugees in Brazil. Conclusions: tracking, touching, landing, attentive recognition, and, above all, the journey as a flâneur-cartographer guide the approach to the territory. Participant-observation of events-activities and interview-meeting with the various participants are simultaneous strategies to follow the processes of the territory, evidencing the research-participation or investigation-interaction, the cartographer’s political role, and the ethos of trust necessary in cartography. The analysis of the jointly produced data occurs throughout the research. Keeping vigilance to scientific norms, cartography configures itself as an affective and political method to assess the relationship between work and subjectivity in existential territories of difficult access. Therefore, the method offers a social contribution, welcoming multiplicity, alterity, and mobility.
DOI: 10.6084/m9.figshare.20847189.v1
title: Cartography as a Research Method for Work and Subjectivity Studies

description: ABSTRACT Objective: the study aims to present cartography as a suitable method to research work and subjectivity in administration. Proposal: in this article, cartography is supported by Deleuze and Guattari’s concept of ‘rhizome,’ aligned to post-structuralism and grounded on administration studies. Finally, this study proposes the flâneur-cartographer as a cross-cutting practice in research. The use of cartography is illustrated by describing the cartographic path of a study on subjectivation processes that make up the immaterial labor of migrants and refugees in Brazil. Conclusions: tracking, touching, landing, attentive recognition, and, above all, the journey as a flâneur-cartographer guide the approach to the territory. Participant-observation of events-activities and interview-meeting with the various participants are simultaneous strategies to follow the processes of the territory, evidencing the research-participation or investigation-interaction, the cartographer’s political role, and the ethos of trust necessary in cartography. The analysis of the jointly produced data occurs throughout the research. Keeping vigilance to scientific norms, cartography configures itself as an affective and political method to assess the relationship between work and subjectivity in existential territories of difficult access. Therefore, the method offers a social contribution, welcoming multiplicity, alterity, and mobility.
DOI: 10.6084/m9.figshare.20847196
title: A Tutorial on the Generalized Method of Moments (GMM) in Finance

description: ABSTRACT Context: empirical problems in which the researcher is faced with a model that is partially specified. In these cases, the GMM method is the natural alternative for estimating the parameters of interest. Objective: the goal of this paper is to offer a tutorial that allows the researcher to understand both the theory and empirical aspects of the GMM method. Methods: we discuss the GMM concepts, forms of estimation, and limitations associated with the method. As a way of illustrating the method, we use two applications in the area of empirical finance. The first application is the estimation of the parameters of a consumption-based asset pricing models; the second is the estimation of the parameters of the evolution of the interest rate in continuous time. The data and codes in R are provided as online appendices. Conclusion: the GMM method can be used in problems where other methods such as maximum likelihood are not feasible, or even when the researcher wants to estimate a model partially specified.
DOI: 10.6084/m9.figshare.20847213
title: In silico investigation on the probable macromolecular drug targets involved in the anti-schizophrenia activity of Nardostachys jatamansi

description: Abstract Existing medications i.e. the antipsychotic drugs are known to be effective in treating only the positive symptoms of schizophrenia, while being ineffective on negative and cognitive symptoms of the disease. In addition, these medications cause extrapyramidal symptoms, forcing many patients towards natural medicine in the hope of minimizing the unwanted adverse effects. Nardostachys jatamansi is a medicinal plant that has been traditionally prescribed for various types of brain disorders. The active constituents of the plant have beneficial effects on the negative and cognitive symptoms of schizophrenia. This study was designed to identify the active constituents of Nardostachys jatamansi with the highest binding affinities for the key macromolecular drug targets involved in the pathophysiology of schizophrenia and thereby elucidate the possible mechanism of action. These targets are dopamine receptors, Gamma-aminobutyric acid receptors, N-methyl-D-aspartate receptors and Phosphodiesterase 10A. The results of molecular docking showed that, β-sitosterol, chlorogenic acid, oleanic acid and ursolic acid, displayed high binding affinity toward all the macromolecular drug targets. Ligands with steroid backbone and pentacyclic triterpene structure have been found to possess high binding affinity toward the dopamine receptor and phosphodiesterase 10A. While ligands with carbonyl group form stronger binding interactions with the N-methyl-D-aspartate receptor.
DOI: 10.6084/m9.figshare.20847213.v1
title: In silico investigation on the probable macromolecular drug targets involved in the anti-schizophrenia activity of Nardostachys jatamansi

description: Abstract Existing medications i.e. the antipsychotic drugs are known to be effective in treating only the positive symptoms of schizophrenia, while being ineffective on negative and cognitive symptoms of the disease. In addition, these medications cause extrapyramidal symptoms, forcing many patients towards natural medicine in the hope of minimizing the unwanted adverse effects. Nardostachys jatamansi is a medicinal plant that has been traditionally prescribed for various types of brain disorders. The active constituents of the plant have beneficial effects on the negative and cognitive symptoms of schizophrenia. This study was designed to identify the active constituents of Nardostachys jatamansi with the highest binding affinities for the key macromolecular drug targets involved in the pathophysiology of schizophrenia and thereby elucidate the possible mechanism of action. These targets are dopamine receptors, Gamma-aminobutyric acid receptors, N-methyl-D-aspartate receptors and Phosphodiesterase 10A. The results of molecular docking showed that, β-sitosterol, chlorogenic acid, oleanic acid and ursolic acid, displayed high binding affinity toward all the macromolecular drug targets. Ligands with steroid backbone and pentacyclic triterpene structure have been found to possess high binding affinity toward the dopamine receptor and phosphodiesterase 10A. While ligands with carbonyl group form stronger binding interactions with the N-methyl-D-aspartate receptor.