cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.15468/dl.uet6by
title: Occurrence Download

description: A dataset containing 11084 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Leptasthenura setaria (Temminck, 1824))",
 "HasCoordinate is true",
 "HasGeospatialIssue is false"
 ]
}

 The dataset includes 11084 records from 17 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0025915-241107131044228/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.6084/m9.figshare.27879594
title: Research Data

description: Grazing practices significantly influence soil carbon dynamics in alpine meadows, with potential implications for carbon sequestration on the Qinghai-Tibet Plateau (QTP). Although previous studies have investigated the effects of grazing on soil properties, limited studies have explored how grazing prohibition (GP) specifically impacts soil carbon accumulation and related enzyme activity over extended periods in this region. This study addresses this gap by analyzing the effects of 6 years of GP on the vegetation community, soil physicochemical properties, and enzyme activities associated with the carbon cycle in winter alpine meadows on the QTP. This study aimed to assess whether GP enhances soil carbon storage by increasing the levels of organic matter, nutrients, and enzyme activities, thus creating a favorable environment for soil carbon accumulation. Our results revealed that GP significantly raised community biomass, soil total carbon, total nitrogen, and reactive organic carbon, while reducing the phenolic content in vegetation, which supports carbon preservation. Enhanced enzyme activities, particularly of β-glucosidase and cellobiohydrolase further contributed to carbon retention. We believe that our study makes a significant contribution to the literature because it highlights grazing prohibition as an effective strategy to enhance soil carbon sequestration in alpine meadows on the Qinghai-Tibet Plateau.
DOI: 10.6084/m9.figshare.27879594.v1
title: Research Data

description: Grazing practices significantly influence soil carbon dynamics in alpine meadows, with potential implications for carbon sequestration on the Qinghai-Tibet Plateau (QTP). Although previous studies have investigated the effects of grazing on soil properties, limited studies have explored how grazing prohibition (GP) specifically impacts soil carbon accumulation and related enzyme activity over extended periods in this region. This study addresses this gap by analyzing the effects of 6 years of GP on the vegetation community, soil physicochemical properties, and enzyme activities associated with the carbon cycle in winter alpine meadows on the QTP. This study aimed to assess whether GP enhances soil carbon storage by increasing the levels of organic matter, nutrients, and enzyme activities, thus creating a favorable environment for soil carbon accumulation. Our results revealed that GP significantly raised community biomass, soil total carbon, total nitrogen, and reactive organic carbon, while reducing the phenolic content in vegetation, which supports carbon preservation. Enhanced enzyme activities, particularly of β-glucosidase and cellobiohydrolase further contributed to carbon retention. We believe that our study makes a significant contribution to the literature because it highlights grazing prohibition as an effective strategy to enhance soil carbon sequestration in alpine meadows on the Qinghai-Tibet Plateau.
DOI: 10.6084/m9.figshare.27135358
title: Etodolac utility in osteoarthritis: drug delivery challenges, topical nanotherapeutic strategies and potential synergies

description: Osteoarthritis (OSA) is a prevalent joint disorder characterized by losing articular cartilage, primarily affecting the hip, knee and spine joints. The impact of OSA offers a major challenge to health systems globally. Therapeutic approaches encompass surgical interventions, non-pharmacological therapies (exercise, rehabilitation, behavioral interventions) and pharmacological treatments. Inflammatory processes within OSA joints are regulated by pro-inflammatory and anti-inflammatory cytokines. Etodolac, a COX-2-selective inhibitor, is the gold standard for OSA management and uniquely does not inhibit gastric prostaglandins. This comprehensive review offers insights into OSA's pathophysiology, genetic factors and biological determinants influencing disease progression. Emphasis is placed on the pivotal role of etodolac in OSA management, supported by both preclinical and clinical evidences in topical drug delivery. Notably, <i>in</i>-<i>silico</i> docking studies suggested potential synergies between etodolac and baicalein, considering ADAMTS-4, COX-2, MMP-3 and MMP-13 as essential therapeutic targets. Integration of artificial neural network (ANN) techniques with nanotechnology approaches emerges as a promising strategy for optimizing and personalizing topical etodolac delivery. Furthermore, the synergistic potential of etodolac and baicalein warrants in-depth exploration. Hence, by embracing cutting-edge technologies like ANN and nanomedicine, the optimization of topical etodolac delivery could guide a new era of OSA treatment. Osteoarthritis extremely affects the quality of life of people in addition to economic burden on the society. Osteoarthritis influences physical functioning, mental health and social life. Osteoarthritis is a prevalent joint disorder characterized by losing articular cartilage, primarily affecting the hip, knee and spine joints. Magnetic resonance imaging is one of the most promising clinical techniques for diagnosis of osteoarthritis. Biomechanical modeling integrated with artificial intelligence algorithms is advantageous in predicting onset and progression of knee osteoarthritis. Etodolac is the gold standard for osteoarthritis management and does not inhibit gastric prostaglandins. Etodolac has the prospective advantage of not destroying articular cartilage <i>in vivo</i>. Etodolac topical delivery offers reduced side effects and controlled release at the site of action. Addition of lidocaine to etodolac ionic liquid augmented permeation efficiency. Nanoemulsion of etodolac enhanced topical drug delivery to suppress edema. Niosomal etodolac topical gel offered superior anti-inflammatory activity. <i>In-silico</i> docking suggested potential synergies between etodolac and baicalein in osteoarthritis. Integration of artificial neural network techniques with nanotechnology driven drug delivery systems may serve to boost topical etodolac delivery.
DOI: 10.6084/m9.figshare.27620584.v1
title: Artemisinin emulgel ameliorates cartilage degradation in knee osteoarthritis: <i>in vitro</i> and <i>in vivo</i> studies

description: <b>Aim:</b> Laboratory scale-up of artemisinin-loaded emulgel (ART-emulgel) was carried out and characterized for therapeutic performance in osteoarthritis (OA). <b>Materials & methods:</b> The solubility of ART in various oils, surfactants and co-surfactants were screened for construction of pseudo ternary phase diagram (TPD), followed by scale-up of artemisinin loaded nanoemulsion (ART-NE). ART-NE was amalgamated with Carbopol Ultrez 10-NF to prepare ART-emulgel that was later characterized <i>in vitro</i> and <i>in vivo</i> to analyze therapeutic efficacy in monosodium-iodoacetate (MIA) induced knee OA. <b>Results:</b> The droplet diameter of ART-NE was estimated to be 104.3 ± 2.593 nm with a polydispersity index of 0.245 ± 0.019 in addition to ζ-potential of 0.434 ± 0.028 mV. Steady-state flux and permeability coefficient for ART-emulgel were estimated to be 0.651 ± 0.031 µg.cm<sup>2</sup>/h and 0.245 ± 0.011 cm/h, respectively. ART-emulgel demonstrated 43.18% reduction in COX-2 level; 52.28% drop in IL-1β, and 88.78% alleviation of Tumor Necrosis Factor-α (TNF-α) level when compared with monosodium-iodoacetate induced OA rats. ART-emulgel and injectable ART (intra-articular; I.A) portrayed minor synovial erosion compared with blank and diclofenac emulgel. Histopathological evidences indicated restoration of cartilage integrity followed by reduction of OARSI scores in ART-emulgel when compared with disease control animals. <b>Conclusion:</b> ART-emulgel is a potential dosage form for translating into a clinically viable product for the management of OA. Artemisinin (ART) has shown critical role in the management of osteoarthritis ART-emulgel owing to submicron size demonstrated high dermal permeation by following the transappendageal pathway ART-emulgel reduces COX-2 expression in addition to TNF-α and IL-1β in experimental osteoarthritic rats. Histopathological analysis revealed restoration of cartilage integrity in ART-emulgel treated group
DOI: 10.6084/m9.figshare.27267906
title: Atorvastatin loaded glycerosomal patch as an effective transdermal drug delivery: optimization and evaluation

description: <b>Aim:</b> The study explores glycerosomes as effective vesicular systems for transdermal delivery of atorvastatin (ATO) to overcome drawbacks related to its oral administration. <b>Methodology:</b> The objectives of this study were to formulate, by thin-film hydration method, optimize using definitive screening design and evaluate ATO-loaded glycerosomes (ATOG) which were then incorporated into patch followed by the evaluation of glycerosomes containing different concentration of glycerol. <b>Results & discussion:</b> Vesicle size, Polydispersity index (PDI), zeta potential, entrapment efficiency and loading capacity of spherical ATOG (0–30%w/w) showed 137.3–192d.nm, 0.292–0.403, -3.81 to-6.76mV, 80.03–92.77% and 5.80–6.40%, respectively. <i>In-vitro</i> release study showed sustained release, increased skin permeability and better cell viability than pure drug. ATOG patches showed greater skin permeability than pure drug and ATO-liposomal patches. <b>Conclusion:</b> The study concludes that ATOGs are promising for effective transdermal delivery. Glycerol is used in glycerosomes which gives elasticity to the vesicle and is a safe component. It increases fluidity and deformability of lipids, enhancing the penetration of vesicles in transdermal delivery. The drug atorvastatin is a selective inhibitor of HMG-CoA. Its oral bioavailability is only 14 % due to gastrointestinal pre-systemic clearance and hepatic first pass metabolism. The transdermal route is explored in the current article to overcome the oral route limitations. Atorvastatin loaded glycerosomes were prepared by thin film hydration method and evaluated for physicochemical characteristics, <i>in vitro</i>, <i>ex vivo</i> and cell line study. ATO-glycerosomes were incorporated into transdermal patch and evaluated for physicochemical characteristics. The results of <i>in vitro</i> and <i>ex vivo</i> studies concluded that the prepared drug delivery systems enhanced the permeation of drug through skin. The ATO loaded glycerosomes and ATOG transdermal patches were more stable than ATO loaded liposomes and liposomal incorporated transdermal patches at 2–8°C and 25 ± 2°C/65 ± 5% RH.
DOI: 10.6084/m9.figshare.27677978
title: Sodium alginate/carboxymethylcellulose gel formulations containing <i>Capparis sepieria</i> plant extract for wound healing

description: <b>Aim:</b> Using appropriate wound dressings is crucial when treating burn wounds to promote accelerated healing. <b>Materials & methods:</b> Sodium alginate (SA)-based gels containing Carboxymethyl cellulose (CMC) and Pluronic F127 were prepared. The formulations. SA/CMC/Carbopol and SA/CMC/PluronicF127 were loaded with aqueous root extract of <i>Capparis sepiaria</i>. The formulations were characterized using appropriate techniques. <b>Results:</b> The gels' viscosity was in the range of 676.33 ± 121.76 to 20.00 ± 9.78 cP and <i>in vitro</i> whole blood kinetics showed their capability to induce a faster clotting rate. They also supported high cell viability of 80% with cellular migration and proliferation. Their antibacterial activity was significant against most bacteria strains used in the study. <b>Conclusion:</b> The gels' distinct features reveal their potential application as wound dressings for burn wounds. Burn wounds are difficult to treat when invaded by microbes. <i>Capparis sepiaria</i> plant extract was loaded into gels. The gel formulations were non-toxic, with good antibacterial effects. These features are useful for the treatment of burn wounds. SA/CMC/Carbopol and SA/CMC/PluronicF127 gels loaded with <i>Capparis sepiaria</i> are potential topical dressings for burn wounds. SA/CMC/Carbopol and SA/CMC/PluronicF127 gels were prepared from sodium alginate, Pluronic F127, Carbopol and Carboxymethylcellulose and loaded with <i>Capparis sepiaria</i> plant extract as promising wound dressings. The gel formulations displayed a non-Newtonian flow, revealing high spreadability and potential uniform distribution when administered topically on the skin surface. These features are appropriate for improving therapeutic efficacy and patient compliance. All the gel formulations displayed good antibacterial efficacy against the gram-negative and gram-positive bacteria. However, SA/CMC/Carbopol gels displayed a significantly more antibacterial effect than the SA/CMC/Pluronic F127 gels and the reason is not fully known and requires further studies. All the prepared gels displayed lower absorbance than Whole blood and plant extract, indicating their capability to control bleeding. However, gels TG6, TG7 and TG8 displayed the lowest absorbance, indicating their capability to induce a rapid rate of clotting, revealing a potential hemostatic effect. The gels exhibited excellent cell viability, indicating non-toxic, good biocompatibility and capability to support cell proliferation. These properties are ideal in an effective wound dressing. The formulation, TG7 selected for <i>in vitro</i> scratch assay study revealed higher closure reduction than the control and untreated cells with a significant capability of controlling bleeding.
DOI: 10.6084/m9.figshare.27135358.v1
title: Etodolac utility in osteoarthritis: drug delivery challenges, topical nanotherapeutic strategies and potential synergies

description: Osteoarthritis (OSA) is a prevalent joint disorder characterized by losing articular cartilage, primarily affecting the hip, knee and spine joints. The impact of OSA offers a major challenge to health systems globally. Therapeutic approaches encompass surgical interventions, non-pharmacological therapies (exercise, rehabilitation, behavioral interventions) and pharmacological treatments. Inflammatory processes within OSA joints are regulated by pro-inflammatory and anti-inflammatory cytokines. Etodolac, a COX-2-selective inhibitor, is the gold standard for OSA management and uniquely does not inhibit gastric prostaglandins. This comprehensive review offers insights into OSA's pathophysiology, genetic factors and biological determinants influencing disease progression. Emphasis is placed on the pivotal role of etodolac in OSA management, supported by both preclinical and clinical evidences in topical drug delivery. Notably, <i>in</i>-<i>silico</i> docking studies suggested potential synergies between etodolac and baicalein, considering ADAMTS-4, COX-2, MMP-3 and MMP-13 as essential therapeutic targets. Integration of artificial neural network (ANN) techniques with nanotechnology approaches emerges as a promising strategy for optimizing and personalizing topical etodolac delivery. Furthermore, the synergistic potential of etodolac and baicalein warrants in-depth exploration. Hence, by embracing cutting-edge technologies like ANN and nanomedicine, the optimization of topical etodolac delivery could guide a new era of OSA treatment. Osteoarthritis extremely affects the quality of life of people in addition to economic burden on the society. Osteoarthritis influences physical functioning, mental health and social life. Osteoarthritis is a prevalent joint disorder characterized by losing articular cartilage, primarily affecting the hip, knee and spine joints. Magnetic resonance imaging is one of the most promising clinical techniques for diagnosis of osteoarthritis. Biomechanical modeling integrated with artificial intelligence algorithms is advantageous in predicting onset and progression of knee osteoarthritis. Etodolac is the gold standard for osteoarthritis management and does not inhibit gastric prostaglandins. Etodolac has the prospective advantage of not destroying articular cartilage <i>in vivo</i>. Etodolac topical delivery offers reduced side effects and controlled release at the site of action. Addition of lidocaine to etodolac ionic liquid augmented permeation efficiency. Nanoemulsion of etodolac enhanced topical drug delivery to suppress edema. Niosomal etodolac topical gel offered superior anti-inflammatory activity. <i>In-silico</i> docking suggested potential synergies between etodolac and baicalein in osteoarthritis. Integration of artificial neural network techniques with nanotechnology driven drug delivery systems may serve to boost topical etodolac delivery.
DOI: 10.6084/m9.figshare.27267906.v1
title: Atorvastatin loaded glycerosomal patch as an effective transdermal drug delivery: optimization and evaluation

description: <b>Aim:</b> The study explores glycerosomes as effective vesicular systems for transdermal delivery of atorvastatin (ATO) to overcome drawbacks related to its oral administration. <b>Methodology:</b> The objectives of this study were to formulate, by thin-film hydration method, optimize using definitive screening design and evaluate ATO-loaded glycerosomes (ATOG) which were then incorporated into patch followed by the evaluation of glycerosomes containing different concentration of glycerol. <b>Results & discussion:</b> Vesicle size, Polydispersity index (PDI), zeta potential, entrapment efficiency and loading capacity of spherical ATOG (0–30%w/w) showed 137.3–192d.nm, 0.292–0.403, -3.81 to-6.76mV, 80.03–92.77% and 5.80–6.40%, respectively. <i>In-vitro</i> release study showed sustained release, increased skin permeability and better cell viability than pure drug. ATOG patches showed greater skin permeability than pure drug and ATO-liposomal patches. <b>Conclusion:</b> The study concludes that ATOGs are promising for effective transdermal delivery. Glycerol is used in glycerosomes which gives elasticity to the vesicle and is a safe component. It increases fluidity and deformability of lipids, enhancing the penetration of vesicles in transdermal delivery. The drug atorvastatin is a selective inhibitor of HMG-CoA. Its oral bioavailability is only 14 % due to gastrointestinal pre-systemic clearance and hepatic first pass metabolism. The transdermal route is explored in the current article to overcome the oral route limitations. Atorvastatin loaded glycerosomes were prepared by thin film hydration method and evaluated for physicochemical characteristics, <i>in vitro</i>, <i>ex vivo</i> and cell line study. ATO-glycerosomes were incorporated into transdermal patch and evaluated for physicochemical characteristics. The results of <i>in vitro</i> and <i>ex vivo</i> studies concluded that the prepared drug delivery systems enhanced the permeation of drug through skin. The ATO loaded glycerosomes and ATOG transdermal patches were more stable than ATO loaded liposomes and liposomal incorporated transdermal patches at 2–8°C and 25 ± 2°C/65 ± 5% RH.
DOI: 10.6084/m9.figshare.27620584
title: Artemisinin emulgel ameliorates cartilage degradation in knee osteoarthritis: <i>in vitro</i> and <i>in vivo</i> studies

description: <b>Aim:</b> Laboratory scale-up of artemisinin-loaded emulgel (ART-emulgel) was carried out and characterized for therapeutic performance in osteoarthritis (OA). <b>Materials & methods:</b> The solubility of ART in various oils, surfactants and co-surfactants were screened for construction of pseudo ternary phase diagram (TPD), followed by scale-up of artemisinin loaded nanoemulsion (ART-NE). ART-NE was amalgamated with Carbopol Ultrez 10-NF to prepare ART-emulgel that was later characterized <i>in vitro</i> and <i>in vivo</i> to analyze therapeutic efficacy in monosodium-iodoacetate (MIA) induced knee OA. <b>Results:</b> The droplet diameter of ART-NE was estimated to be 104.3 ± 2.593 nm with a polydispersity index of 0.245 ± 0.019 in addition to ζ-potential of 0.434 ± 0.028 mV. Steady-state flux and permeability coefficient for ART-emulgel were estimated to be 0.651 ± 0.031 µg.cm<sup>2</sup>/h and 0.245 ± 0.011 cm/h, respectively. ART-emulgel demonstrated 43.18% reduction in COX-2 level; 52.28% drop in IL-1β, and 88.78% alleviation of Tumor Necrosis Factor-α (TNF-α) level when compared with monosodium-iodoacetate induced OA rats. ART-emulgel and injectable ART (intra-articular; I.A) portrayed minor synovial erosion compared with blank and diclofenac emulgel. Histopathological evidences indicated restoration of cartilage integrity followed by reduction of OARSI scores in ART-emulgel when compared with disease control animals. <b>Conclusion:</b> ART-emulgel is a potential dosage form for translating into a clinically viable product for the management of OA. Artemisinin (ART) has shown critical role in the management of osteoarthritis ART-emulgel owing to submicron size demonstrated high dermal permeation by following the transappendageal pathway ART-emulgel reduces COX-2 expression in addition to TNF-α and IL-1β in experimental osteoarthritic rats. Histopathological analysis revealed restoration of cartilage integrity in ART-emulgel treated group