cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.23735643
title: Supplementary Material for: Underwater endoscopic mucosal resection for a terminal ileum adenoma

description: Tumors of the terminal ileum are rare, and their diagnosis and treatment standards have not been established. The effectiveness of underwater endoscopic mucosal resection (UEMR) in the duodenum and colon has been reported; however, its effectiveness in the small intestine is rarely reported. We present a case of an ileum adenoma diagnosed using magnifying endoscopy that was completely resected using UEMR. A 56-year-old woman with a lesion in the terminal ileum was referred to our hospital for treatment. Colonoscopy revealed a 10- mm slightly depressed lesion with marginal elevation in the terminal ileum. Magnifying narrow-band imaging (NBI) showed a tubular surface pattern with regular vessels on the slightly elevated marginal area and regular brown vessels on the slightly depressed central area. Magnifying chromoendoscopy using crystal violet staining showed a branch-like or gyrus-like pattern on the marginal area, and a roundish and tubular structure on the central area. The lesion was diagnosed as an adenoma in the terminal ileum, similar to a colonic adenoma; hence, we decided to perform UEMR. The lesion was completely removed using a 10- mm snare. The pathological diagnosis revealed that it was an intestinal-type adenoma with negative margins. At the margins of the lesions, the tumor tended to form a villous structure, while the center appeared tubular with a relatively flat surface. These histopathological findings were consistent with the magnifying endoscopic findings. UEMR for terminal ileum tumors may be effective in their treatment.
DOI: 10.6084/m9.figshare.24031773
title: Supplementary Material for: Case Report of Seronegative Cancer Associated Retinopathy in a Patient with Small Cell Lung Carcinoma

description: Cancer associated retinopathy (CAR) is a rare paraneoplastic syndrome characterized by autoimmune destruction of photoreceptor cells. It is associated with several tumor types, including small cell lung carcinoma (SCLC). Corticosteroids have been the mainstay treatment for CAR, although no therapeutic standard has truly been established. A 66-year-old female with significant smoking history and age-related macular degeneration (ARMD) presented with rapidly declining bilateral visual acuity. Ophthalmologic exam findings appeared consistent with the known diagnosis of ARMD but did not otherwise present a clear alternative etiology. Imaging with a computed tomography (CT) scan revealed a right hilar mass which was confirmed to be limited stage small cell lung cancer (SCLC) based on a subsequent biopsy and further imaging with a positron emission tomography/computed tomography (PET/CT) scan. Antibody testing was negative for anti-recoverin antibodies. The patient experienced a complete response to chemoradiation with cisplatin and etoposide, however her ocular symptoms did not respond to a combined treatment approach with corticosteroids, plasmapheresis, and intravenous immunoglobulin (IVIG). While CAR represents a rare condition in SCLC, cases that are seronegative for anti-recoverin are even less common. Further, the diagnosis of CAR by ophthalmologic exam may be made more challenging in patients with pre-existing ocular disease, such as macular degeneration. Clinicians should have suspicion for paraneoplastic blindness in patients with known risk factors for malignancy, whose ocular symptoms are inconsistent with exam findings.
DOI: 10.6084/m9.figshare.24070986
title: Supplementary Material for: A 37-year-old man with myofibroblast sarcoma combined with pleural maculopathy: Case report

description: Myofibroblastic Sarcoma (MS) is a malignant tumor of soft tissue or bone that can occur in children or adults, with a high rate of recurrence and metastasis. We report a case of low-grade malignant MS of the left shoulder, diagnosed based on pathological examination and immunohistochemical staining. However, the patient had unexplained pleural maculopathy. The patient passed away six months after the diagnosis of myofibroblast sarcoma due to multiple metastases throughout the sarcoma. Combined with the patient's history, ancillary findings, and after MDT discussion, the patient was ultimately considered to have a high probability of myofibroblast sarcoma combined with pleural maculopathy. In conclusion, when a patient is diagnosed with myofibroblast sarcoma in combination with pleural macula, in the absence of other causative factors, a deep tissue biopsy of the pleura should be actively performed to confirm the diagnosis.
DOI: 10.6084/m9.figshare.24080427
title: Supplementary Material for: High-mobility group box 1 overexpression predicts a poor prognosis and promotes EMT in gastric cancer by activating TLR4/NF-κB signaling.

description: Objective The molecular mechanism of high-mobility group box 1(HMGB1) promoting the epithelial-mesenchymal transition (EMT) of gastric cancer(GC) has not been known well. This study aimed to explore the clinical effects of HMGB1 expression levels on the clinicopathological characteristics of patients with GC and to uncover the potential molecular mechanism by which promoting tumor progression. Methods The expression levels of HMGB1 in 125 pairs of patients with GC were detected by IHC and western blotting. Univariate and multivariate analyses were performed to evaluate the relationship between HMGB1 expression and clinical characteristics of patients with GC. Stable overexpression(Over-HMGB1) and knockdown(sh-HMGB1) GC cell lines(AGS and MKN-45) were used to determine the effects of HMGB1 on the activation of TLR4/NF-κB signaling. Differences were considered statistically significant at p&lt;0.05 in two sides. Results HMGB1 is highly expressed in GC tissues and cell lines. High HMGB1 expression (HR=1.89, 95%CI:1.44-2.39, p=0.001) was an independent risk factor for OS in patients with GC. Downregulation of HMGB1 resulted in downregulation of TLR4 and NF-κB subunit (p-p65 and p-IκBα) expression, whereas the upregulated expression of HMGB1 led to increased expression of TLR4 and NF-κB subunits. Overexpression of HMGB1 promotes the upregulation of EMT-TF expression, which enhances the proliferation and migration abilities of GC cell lines. Conclusion HMGB1 is highly expressed in GC tissues and is associated with a poorer prognosis in patients with GC. HMGB1 activates the TLR4/NF-κB signaling pathway to promote EMT progression in GC cell lines. HMGB1 may be a critical molecule in prognosis prediction and a therapeutic target for patients with GC.
DOI: 10.6084/m9.figshare.24118287
title: Supplementary Material for: Interoceptive and affective alterations in Body Integrity Dysphoria: An online self-reporting study

description: Introduction: Body Integrity Dysphoria (BID) is a rare condition in which individuals experience a long-lasting desire to achieve a specific physical disability. In this study, we tested the hypothesis of interoceptive and affective abnormalities in BID, in line with the evidence of structural and functional alteration of the interoceptive-affective neural system in these individuals. Method: Our study involved 68 participants with BID (mean age 35.6, SD 16.4). Among these participants, 47 expressed a desire for amputation, 14 desired paralysis, 3 sought sensory deprivation, and 3 desired a combination of these forms. For comparisons, we recruited a control group of 79 participants (mean age 35.2, SD 15.8). We administered assessment measures to investigate alexithymia level (TAS-20), disgust sensitivity (DS-R), interoceptive awareness (MAIA-2), and (affective and cognitive) empathy (QCAE). We also administered the Short Oxford-Liverpool Inventory of Feelings and Experiences (O-LIFE) to identify psychiatric comorbidities. Subgroups with Low O-LIFE scores (BID=31; Controls=43) and subgroups with High O-LIFE scores (BID=37; Controls=36) were derived through a median-split procedure. Results: Within the BID Low O-LIFE group, we found reduced interoceptive sensibility, reduced disgust sensitivity, and increased difficulty in identifying feelings, which refers to a dimension of the alexithymia trait. Within the BID High O-LIFE group, we observed a reduced disgust sensitivity and interoceptive sensibility, accompanied by a diminished score in cognitive empathy. Conclusion: Our study suggests that BID can be associated with altered interoceptive and affective processing.
DOI: 10.6084/m9.figshare.24125976
title: Supplementary Material for: The Relationship between Allergic Disease and Sexual Dysfunction: A Scoping Review

description: Introduction: Sexual dysfunction (SD) and allergic disease are common health concerns worldwide and bear potential relationship. This scoping review is conducted to analyze the currently available data regarding the associations between these two health issues. Methods: A comprehensive literature search was performed in the databases of Pubmed, MEDLINE, Embase, Cochrane Central Register of Controlled Trials (CENTRAL), and Web of Science to retrieve studies that were published before January 2023. A narrative synthesis was conducted to analyze the effects of allergic diseases on SD based on the evaluation of the Female Sexual Function Index (FSFI) and International Index of Erectile Function (IIEF). Results: Twelve observational studies were included after the selection process. The results generally suggested lower FSFI or IIEF scores in patients with asthma, allergic rhinitis, allergic rhinoconjunctivitis, and urticaria compared to the healthy control groups. The underlying factors of this relationship could be inflammation, psychological factors, hormonal changes, sleep disorders, sexual behavior-related allergic reactions, social economic status, and the use of medications. Conclusion: SD and allergic disease are interrelated based on extant literature. This scoping review provides insights into the clinical implications of both entities, while more researches are warranted to further elucidate this complex relationship.
DOI: 10.6084/m9.figshare.24131589
title: Supplementary Material for: Venetoclax–azacitidine bridging PTCy-haplo-PBSCT for refractory acute myeloid leukemia with IDH2 mutations

description: Venetoclax and azacitidine combination therapy (VEN+AZA) is a promising novel therapy for elderly or unfit patients with acute myeloid leukemia (AML). Recently, VEN+AZA with subsequent allo-hematopoietic stem cell transplantation (allo-HSCT) has been reported, and human leukocyte antigen (HLA)-haploidentical peripheral blood stem cell transplantation using post-transplant cyclophosphamide (PTCy-haplo-PBSCT) from related donors appears to be a suitable option. Here, we report two elderly patients with refractory AML harboring an IDH2 mutation, which was successfully treated with VEN+AZA bridged to PTCy-haplo-PBSCT. This report suggests the efficacy and safety of VEN+AZA as a bridging treatment for PTCy-haplo-PBSCT in refractory AML.
DOI: 10.6084/m9.figshare.24155169
title: Supplementary Material for: Trends in accuracy and appropriateness of alopecia areata information obtained from a popular online large language model, ChatGPT

description: Patients with alopecia areata (AA) may access a wide range of sources for information about AA, including the recently developed ChatGPT. Assessing the quality of health information provided by these sources is crucial, as patients are utilizing them in increasing numbers. This study aimed to evaluate appropriateness and accuracy of responses to common patient questions about AA generated by ChatGPT. Responses generated by ChatGPT 3.5 and ChatGPT 4.0 to 25 questions addressing common patient concerns were assessed by multiple attending dermatologists in an academic center for appropriateness and accuracy. Appropriateness of responses by both models for use in two hypothetical contexts: 1) for patient-facing general information websites, and 2) for electronic health record (EHR) message drafts were measured. This study found the accuracy across all responses was 4.41 out of 5. Accuracy scores of responses ChatGPT 3.5 responses had a mean of 4.29, whereas those generated by ChatGPT 4.0 had mean accuracy score of 4.53. Assessments ranged from 100% of responses rated as appropriate for the general question category to 79% questions about management for an EHR message draft. Raters largely preferred responses generated by ChatGPT 4.0 vs. ChatGPT 3.5. Reviewer agreement was found to be moderate across all questions, with a 53.7% agreement and Fleiss’ κ co-efficient of 0.522 (p-value &lt; 0.001). The large language model ChatGPT outputted mostly appropriate information for common patient concerns. While not all responses were accurate, the trend toward improvement with newer iterations suggests potential future utility for patients and dermatologists.
DOI: 10.14284/441
title: LifeWatch observatory data: nutrient, pigment, suspended matter and secchi measurements in the Belgian Part of the North Sea

description: In the framework of the Lifewatch marine observatory a number of fixed stations on the Belgian Part of the North Sea (BPNS) are visited on a monthly or seasonal basis using the RV Simon Stevin. A grid of nine stations covers the coastal zone and are sampled monthly. Eight additional stations, located further at sea, are sampled on a seasonal basis. This dataset contains measurements of nutrients, pigments, suspended matter and secchi measurements in the Belgian Part of the North Sea (BPNS) since 2001.
DOI: 10.14284/536
title: ICOS and LifeWatch observatory data: buoy data

description: A set of buoys are maintained by the Flanders Marine Institute (VLIZ): two in the sluice dock (Ostend) and one at the C-power windfarm, on the Thornton Bank. All buoys are continuously measuring an array of environmental parameters.
description: In conjunction with the research vessel RV Simon Stevin, the Thornthon measuring buoy is part of the oceanographic component of ICOS Belgium (The Integrated Carbon Observation System). The Thornton buoy carries sensors for both LifeWatch and ICOS. Management is organized as part of ICOS. ICOS is a European monitoring network consisting of a large number of observation systems for measuring greenhouse gasses. The observation systems are spread across Europe and consist of three major components: 1. An atmospheric component with high measurement towers 2. An ecosystem component with measurement towers that observe fluxes 3. An oceanographic component with observation systems on ships and buoys
DOI: 10.15121/1452735
title: Utah FORGE: Logs and Data from Deep Well 58-32 (MU-ESW1)

description: Data, logs, and graphics associated with the drilling and testing of Utah FORGE deep test well 58-32 (MU-ESW1) near Roosevelt Hot Springs.
DOI: 10.5517/cc13j4g7
title: CCDC 1028408: Experimental Crystal Structure Determination

description: Related Article: Florian E. Golling, Volker Enkelmann, Klaus Müllen|2014|CSD Communication|||
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.6084/m9.figshare.23931279
title: Supplementary Material for: Higher Sensitivity to Thyroid Hormones may be Linked to Maintaining the Healthy Metabolic Condition in Population with Obesity: New Insight from NHANES

description: Introduction: Obesity contributes to the pathogenesis of diverse metabolic diseases, and yet the mechanism underlying metabolically healthy obesity (MHO) remains elusive. Thyroid hormones and sensitivity to them have a major impact on human metabolism. Our study investigated whether MHO is associated with thyroid hormone sensitivity. Methods: Thyroid hormone indices, including the thyroid stimulating hormone (TSH) index (TSHI), the thyrotroph thyroxine sensitivity index (TTSI), the thyroid feedback quantile-based index (TFQI), and the parametric thyroid feedback quantile-based Index (PTFQI), were calculated based on a non-institutionalized U.S. sample in the National Health and Nutrition Examination Survey (NHANES, 2007–2012). Participants were divided into four groups (metabolically healthy non-obesity [MHNO], metabolically unhealthy non-obesity [MUNO], MHO, and metabolically unhealthy obesity [MUO]) according to their body mass index and metabolic profiles. Linear regression, logistic regression, and restricted cubic splines were used to study the association between thyroid hormone indices and metabolic phenotypes. Results: A total of 4,857 participants (49.6% men; mean age, 42.6 years) were included. Of these, 1,539 had obesity and 235 were identified as having MHO. Compared with the MHNO group, participants with MHO had a lower level of TSH, TSHI, TTSI, TFQI, and PTFQI (all P &lt; 0.05), but the differences among MHNO, MUNO, and MUO were not significant (all P &gt; 0.05). Among the participants with obesity, TSH, TSHI, TTSI, TFQI, and PTFQI were positively associated with metabolic abnormality (all P &lt; 0.05). Discussion/Conclusion: The MHO population exhibited higher thyroid hormone sensitivity among various obesity phenotypes, even when compared to those with MHNO. A positive association was observed between metabolic abnormality and thyroid hormone sensitivity, while the trend of TSH was observed to be consistent with sensitivity to thyroid hormone indices in discriminating metabolic abnormality. Hence, TSH has potential as a convenient index for detecting sensitivity to thyroid hormone and further metabolic conditions.
DOI: 10.6084/m9.figshare.24105723
title: Supplementary Material for: Association between the dietary inflammatory index and all-cause mortality in adults with obesity

description: Introduction: The dietary inflammatory index (DII) is associated with numerous chronic non-communicable diseases. Previous studies have shown that the pro-inflammatory DII categories are associated with abdominal and simple obesity. However, the association between DII and mortality in patients with abdominal obesity and simple overweight or obesity remains unclear. Methods: We used data from the United States National Health and Nutrition Examination Survey (NHANES) from 2007 to 2018. A DII &gt;0 (positive DII) was defined as a pro-inflammatory diet. A restricted cubic spline curve was used to describe the trend between DII and all-cause mortality. We then examined the association between DII and all-cause mortality in different body types using a Cox regression analysis and investigated the differences between sexes. Finally, the mediating effects of systemic inflammation were explored. Results: A pro-inflammatory diet increased all-cause mortality in adults with abdominal obesity (aHR: 1.31, 95% CI: 1.11–1.54; P&lt;0.001) and with simple overweight or obesity (aHR: 1.30, 95% CI: 1.11–1.53; P&lt;0.001). In addition, the most pro-inflammatory DII increased the risk of mortality by 43 % (HR: Q4 vs Q1 = 1.43, 95% CI = 1.14–1.79; P=0.002; P for trend=0.003) and 39 % (HR: Q4 vs Q1 = 1.39, 95% CI = 1.13–1.74; P=0.003; P for trend=0.009) in participants with abdominal obesity and with simple overweight or obesity, respectively. However, this association was not present in normal-sized participants. Compared with men, women resisted the effects of a pro-inflammatory diet. Mediation analysis showed that white blood cell and neutrophil were mediators of the association between DII and all-cause mortality (P&lt;0.001). Conclusion: A pro-inflammatory diet is associated with all-cause mortality in adults with abdominal obesity and simple overweight or obesity, and this effect differs between men and women. Systemic inflammation may mediate the association between DII and all-cause mortality.
DOI: 10.6084/m9.figshare.24155586
title: Supplementary Material for: Isolated Pancreatic Metastasis From a Lung Adenocarcinoma Primary: A Case Report and Literature Review

description: Isolated pancreatic metastasis is a rare occurrence and is commonly misdiagnosed as primary pancreatic malignancy. We present a case of a 65-year-old female patient with a history of stage IIIA lung adenocarcinoma, who developed significant epigastric pain 27 months after diagnosis and treatment of a primary lung adenocarcinoma. This patient was found to have a pancreatic head lesion initially suspected to be a primary pancreatic neoplasm but eventually discovered to be a metastatic lesion from the previously treated primary lung adenocarcinoma.
DOI: 10.6084/m9.figshare.22241593
title: Supplementary Material for: Carcinoid Heart Disease Induced Right Sided Heart Failure as a Culprit for Significant Ascites

description: The diagnosis of carcinoid heart disease as a cause of ascites can be hard to establish. We report a patient with well-differentiated neuroendocrine neoplasm of the liver who presented with high serum ascites albumin gradient and high protein ascites due to carcinoid heart disease (CHD). As ascites caused by CHD is rare, the etiology can easily be overlooked especially in the setting of alcohol use disorder and portal hypertension. Through our case report, we emphasize the importance of physical examination and peritoneal fluid analysis in the diagnosis of CHD. As the management of CHD requires a multidisciplinary approach, early diagnosis is crucial so that relevant specialists can have the opportunity for early intervene in order to produce the best patient outcome.
DOI: 10.5525/gla.researchdata.1514
title: A method for crystallographic mapping of an alpha-beta titanium alloy with nanometre resolution using scanning precession electron diffraction and open-source software libraries

description: A large 4DSTEM dataset (scanning precession electron diffraction), one image of the larger area from within which the dataset was recorded, and processing notebooks to perform the analysis undertaken in the paper.
DOI: 10.5519/qd.toulbopn
title: Query on the Natural History Museum Data Portal (data.nhm.ac.uk) (1 records)
DOI: 10.5281/zenodo.10020866
title: BBC Maida Vale Impulse Response Dataset

description: This repository presents a dataset of spatial impulse responses measured from the BBC Maida Vale Studios.
The measurements were undertaken in Summer/Autumn 2021 by researchers from the University of York, led by Prof Gavin Kearney and Prof Helena Daffern and team members of BBC R&D. 
The measured studio live rooms presented here are studios MV4 and MV5.
The dataset for each room includes:
- Higher Order Ambisonic (3rd Order) spatial impulse responses for 3DOF/6DOF rendering.
- Reference KEMAR binaural measurements
- ISO-3382 measurements.
- Readme files for each room. 
 
Important notes: 
- If you use this dataset, please cite the following paper in your work:
Kearney, G., Daffern, H., Cairns, P., Hunt, A., Lee, B., Cooper, J., Tsagkarakis, P., Rudzki, T. and Johnston, D., 2022, September. Measuring the Acoustical Properties of the BBC Maida Vale Recording Studios for Virtual Reality. In Acoustics (Vol. 4, No. 3, pp. 783-799). MDPI.
- Source orientations have been measured in the four cardinal directions (N, E, S, W) and impulse responses can be combined to simulate sources with first order directivity patterns. See paper above for further details. 
- For 3DOF/6DOF measurements, Ambix config files are also included for quick audition of the IRs using an appropriate convolver (e.g. MCFX convolver http://www.matthiaskronlachner.com/?p=1910). 
- The ISO measurements should not be used for auralisation.
- Measurements taken from the same source-receiver position should ideally not be used directly. If you wish to simulate the same source/receiver position for natural reverberation foldback, then the direct sound portion should be removed as the frequency reponse of this component will be imbalanced, and should be replaced with direct monitoring of a close miked source via your soundcard. 
If you have any questions about the dataset, please contact gavin.kearney@york.ac.uk