cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.6737282.v1
title: Survival and prognostic indicators of Budd–Chiari syndrome: a systematic review of 79 studies

description: This paper aimed to systematically review the survival of Budd–Chiari syndrome and to identify the most robust prognostic predictors. Overall, 79 studies were included. According to the treatment modalities, the median 1-, 5- and 10-year survival rate was 93, 83 and 73% after interventional radiological treatment; 81, 75 and 72.5% after surgery other than liver transplantation; 82.5, 70.2 and 66.5% after liver transplantation and 68.1, 44.4% and unavailable after medical therapy alone. According to the publication years, the median 1-, 5- and 10-year survival rate was 68.6, 44.4% and unavailable before 1990; 75.1, 69.5 and 57% during the year 1991–1995; 77, 69.6 and 65.6% during the year 1996–2000; 86.5, 74 and 63.5% during the year 2001–2005 and 90, 82.5 and 72% after 2006. Bilirubin, creatinine and ascites were more frequently identified as significant prognostic factors in univariate analyses. But their statistical significance was less frequently achieved in multivariate analyses.
DOI: 10.6084/m9.figshare.6737273.v1
title: Cladribine in combination with entinostat synergistically elicits anti-proliferative/anti-survival effects on multiple myeloma cells

description: Cladribine (2CdA), a synthetic purine analog interfering with DNA synthesis, is a medication used to treat hairy cell leukemia (HCL) and B-cell chronic lymphocytic leukemia. Entinostat, a selective class I histone deacetylase (HDAC) inhibitor, shows antitumor activity in various human cancers, including hematological malignancies. The therapeutic potential of cladribine and entinostat against multiple myeloma (MM) remains unclear. Here we investigate the combinatorial effects of cladribine and entinostat within the range of their clinical achievable concentrations on MM cells. While either agent alone inhibited MM cell proliferation in a dose-dependent manner, their combinations synergistically induced anti-proliferative/anti-survival effects on all MM cell lines (RPMI8226, U266, and MM1.R) tested. Further studies showed that the combinations of cladribine and entinostat as compared to either agent alone more potently induced mitotic catastrophe in the MM cells, and resulted in a marked increase of the cells at G1 phase associated with decrease of Cyclin D1 and E2F-1 expression and upregulation of p21<sup>waf−1</sup>. Apoptotic ELISA and western blot analyses revealed that the combinations of cladribine and entinostat exerted a much more profound activity to induce apoptosis and DNA damage response, evidenced by enhanced phosphorylation of histone H2A.X and the DNA repair enzymes Chk1 and Chk2. Collectively, our data demonstrate that the combinations of cladribine and entinostat exhibit potent activity to induce anti-proliferative/anti-survival effects on MM cells via induction of cell cycle G1 arrest, apoptosis, and DNA damage response. Regimens consisting of cladribine and/or entinostat may offer a new treatment option for patients with MM. <b>Abbreviations:</b> MM, multiple myeloma; HCL, hairy cell leukemia; HDAC, histone deacetylase; Ab, antibody; mAb, monoclonal Ab; FBS, fetal bovine serum; CI, combination index; PAGE, polyacrylamide gel electrophoresis; ELISA, enzyme-linked immunosorbent assay; PARP, poly(ADP-ribose) polymerase; MTS, 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium,inner salt
DOI: 10.6084/m9.figshare.6737153
title: Tectonic switching of Southeast South in the late Paleozoic

description: SIMS zircon U-Pb ages for the Daixi-Wufenglou granites and the Houzhang Complex<b>Four tables are included. Table S1. SIMS zircon U-Pb ages for the Daixi-Wufenglou granites and the Houzhang complex; Table S2. Zircon Hf-O isotopic composition for the Daixi-Wufenglou granites and the Houzhang complex; Table S3. Whole rock major (wt%) and trace elements (ppm) analyses for the Daixi-Wufenglou granites and the Houzhang complex; Table S4. Sr and Nd isotopic compositions for the Daixi-Wufenglou granites and the Houzhang complex</b>
DOI: 10.6084/m9.figshare.6737150
title: Table S3.xlsxTectonic switching of Southeast South in the late Paleozoic

description: Zircon Hf-O isotopic composition for the Daixi-Wufenglou granites and the Houzhang Complex<b>Four tables are included. Table S1. SIMS zircon U-Pb ages for the Daixi-Wufenglou granites and the Houzhang complex; Table S2. Zircon Hf-O isotopic composition for the Daixi-Wufenglou granites and the Houzhang complex; Table S3. Whole rock major (wt%) and trace elements (ppm) analyses for the Daixi-Wufenglou granites and the Houzhang complex; Table S4. Sr and Nd isotopic compositions for the Daixi-Wufenglou granites and the Houzhang complex</b>
DOI: 10.6084/m9.figshare.6737153.v1
title: Table S4.xlsx

description: SIMS zircon U-Pb ages for the Daixi-Wufenglou granites and the Houzhang Complex
DOI: 10.6084/m9.figshare.6737153.v2
title: Table S4.xlsxTectonic switching of Southeast South in the late Paleozoic

description: SIMS zircon U-Pb ages for the Daixi-Wufenglou granites and the Houzhang Complex<b>Four tables are included. Table S1. SIMS zircon U-Pb ages for the Daixi-Wufenglou granites and the Houzhang complex; Table S2. Zircon Hf-O isotopic composition for the Daixi-Wufenglou granites and the Houzhang complex; Table S3. Whole rock major (wt%) and trace elements (ppm) analyses for the Daixi-Wufenglou granites and the Houzhang complex; Table S4. Sr and Nd isotopic compositions for the Daixi-Wufenglou granites and the Houzhang complex</b>
DOI: 10.6084/m9.figshare.6737150.v1
title: Table S3.xlsx

description: Zircon Hf-O isotopic composition for the Daixi-Wufenglou granites and the Houzhang Complex
DOI: 10.6084/m9.figshare.6737150.v2
title: Table S3.xlsxTectonic switching of Southeast South in the late Paleozoic

description: Zircon Hf-O isotopic composition for the Daixi-Wufenglou granites and the Houzhang Complex<b>Four tables are included. Table S1. SIMS zircon U-Pb ages for the Daixi-Wufenglou granites and the Houzhang complex; Table S2. Zircon Hf-O isotopic composition for the Daixi-Wufenglou granites and the Houzhang complex; Table S3. Whole rock major (wt%) and trace elements (ppm) analyses for the Daixi-Wufenglou granites and the Houzhang complex; Table S4. Sr and Nd isotopic compositions for the Daixi-Wufenglou granites and the Houzhang complex</b>
DOI: 10.6084/m9.figshare.6737153.v3
title: Table S4.xlsxTectonic switching of Southeast South in the late Paleozoic

description: SIMS zircon U-Pb ages for the Daixi-Wufenglou granites and the Houzhang Complex<b>Four tables are included. Table S1. SIMS zircon U-Pb ages for the Daixi-Wufenglou granites and the Houzhang complex; Table S2. Zircon Hf-O isotopic composition for the Daixi-Wufenglou granites and the Houzhang complex; Table S3. Whole rock major (wt%) and trace elements (ppm) analyses for the Daixi-Wufenglou granites and the Houzhang complex; Table S4. Sr and Nd isotopic compositions for the Daixi-Wufenglou granites and the Houzhang complex</b>
DOI: 10.6084/m9.figshare.6737153.v4
title: Tectonic switching of Southeast South in the late Paleozoic

description: SIMS zircon U-Pb ages for the Daixi-Wufenglou granites and the Houzhang Complex<b>Four tables are included. Table S1. SIMS zircon U-Pb ages for the Daixi-Wufenglou granites and the Houzhang complex; Table S2. Zircon Hf-O isotopic composition for the Daixi-Wufenglou granites and the Houzhang complex; Table S3. Whole rock major (wt%) and trace elements (ppm) analyses for the Daixi-Wufenglou granites and the Houzhang complex; Table S4. Sr and Nd isotopic compositions for the Daixi-Wufenglou granites and the Houzhang complex</b>
DOI: 10.6084/m9.figshare.6737138
title: Discoidin domain receptors: multitaskers for physiological and pathological processes

description: Discoidin domain receptors: multitaskers for physiological and pathological processes
DOI: 10.6084/m9.figshare.6737138.v2
title: Discoidin domain receptors: multitaskers for physiological and pathological processes

description: Discoidin domain receptors: multitaskers for physiological and pathological processes
DOI: 10.6084/m9.figshare.6737138.v1
title: Discoidin Domain receptors: multitaskers for physiological and pathological processes

description: Discoidin Domain receptors: multitaskers for physiological and pathological processes
DOI: 10.6084/m9.figshare.6737129
title: Table S1.xlsxTectonic switching of Southeast South in the late Paleozoic

description: Sr and Nd isotopic compositions for the Daixi-Wufenglou granites and the Houzhang Complex<b>Four tables are included. Table S1. SIMS zircon U-Pb ages for the Daixi-Wufenglou granites and the Houzhang complex; Table S2. Zircon Hf-O isotopic composition for the Daixi-Wufenglou granites and the Houzhang complex; Table S3. Whole rock major (wt%) and trace elements (ppm) analyses for the Daixi-Wufenglou granites and the Houzhang complex; Table S4. Sr and Nd isotopic compositions for the Daixi-Wufenglou granites and the Houzhang complex</b>
DOI: 10.6084/m9.figshare.6737129.v1
title: Table S1.xlsx

description: Sr and Nd isotopic compositions for the Daixi-Wufenglou granites and the Houzhang Complex
DOI: 10.6084/m9.figshare.6736997
title: The mitotic spindle is chiral due to torques within microtubule bundles

description: Scientific data from paper: The mitotic spindle is chiral due to torques within microtubule bundles<br>Bundles in 3D images of metaphase spindles of human cells were tracked manually using Multi-point tool in Fiji (ImageJ).<br>Attached tables contain the coordinates (x, y, z) of all bundles and spindle poles. Coordinates of bundles and poles from images of spindles were transformed so that both poles are on the z-axis. First and last row of each table contain coordinates of spindle poles.<br><br><br>
DOI: 10.6084/m9.figshare.6737015.v1
title: Supplementary videos from Population dynamics of synthetic terraformation motifs

description: Ecosystems are complex systems, currently experiencing several threats associated with global warming, intensive exploitation and human-driven habitat degradation. Because of a general presence of multiple stable states, including states involving population extinction, and due to the intrinsic nonlinearities associated with feedback loops, collapse in ecosystems could occur in a catastrophic manner. It has been recently suggested that a potential path to prevent or modify the outcome of these transitions would involve designing synthetic organisms and synthetic ecological interactions that could push these endangered systems out of the critical boundaries. In this paper, we investigate the dynamics of the simplest mathematical models associated with four classes of ecological engineering designs, named <i>Terraformation motifs</i> (TMs). These TMs put in a nutshell different ecological strategies. In this context, some fundamental types of bifurcations pervade the systems; dynamics. Mutualistic interactions can enhance persistence of the systems by means of saddle-node bifurcations. The models without cooperative interactions show that ecosystems achieve restoration through transcritical bifurcations. Thus, our analysis of the models allows us to define the stability conditions and parameter domains where these TMs must work.
DOI: 10.6084/m9.figshare.6736997.v1
title: The mitotic spindle is chiral due to torques within microtubule bundles

description: Scientific data from paper: The mitotic spindle is chiral due to torques within microtubule bundles<br>Bundles in 3D images of metaphase spindles of human cells were tracked manually using Multi-point tool in Fiji (ImageJ).<br>Attached tables contain the coordinates (x, y, z) of all bundles and spindle poles. Coordinates of bundles and poles from images of spindles were transformed so that both poles are on the z-axis. First and last row of each table contain coordinates of spindle poles.<br><br><br>
DOI: 10.6084/m9.figshare.6736934
title: Marchantia inflexa fluctuating sexual dimorphism

description: This item includes data on recovery from dehydration treatment for the dehydration tolerant tropical liverwort <i>Marchantia inflexa</i>. Data characterizing the environmental conditions at field sites are also included.
DOI: 10.6084/m9.figshare.6736934.v2
title: Marchantia inflexa fluctuating sexual dimorphism

description: This item includes data on recovery from dehydration treatment for the dehydration tolerant tropical liverwort <i>Marchantia inflexa</i>. Data characterizing the environmental conditions at field sites are also included.
DOI: 10.6084/m9.figshare.6736931
title: Supplementary Material for: Unique <b><i>Francisella</i></b> Phosphatidylethanolamine Acts as a Potent Anti-Inflammatory Lipid

description: Virulent <i>Francisella tularensis</i> subsp. <i>tularensis</i> (Ftt) is a dynamic, intracellular, bacterial pathogen. Its ability to evade and rapidly suppress host inflammatory responses is considered a key element for its profound virulence. We previously established that Ftt lipids play a role in inhibiting inflammation, but we did not determine the lipid species mediating this process. Here, we show that a unique, abundant, phosphatidylethanolamine (PE), present in <i>Francisella</i>, contributes to driving the suppression of inflammatory responses in human and mouse cells. Acyl chain lengths of this PE, C24: 0 and C10: 0, were key to the suppressive capabilities of <i>Francisella</i> PE. Addition of synthetic PE 24: 0–10: 0 resulted in the accumulation of PE in host cells for up to 24 h of incubation, and recapitulated the inhibition of inflammatory responses observed with native Ftt PE. Importantly, this novel PE significantly inhibited inflammatory responses driven by a medically and globally important flavivirus, dengue fever virus. Thus, targeting these lipids and/or the pathways that they manipulate represents a new strategy to combat immunosuppression engendered by Ftt, but they also show promise as a novel therapeutic intervention for significant viral infections.
DOI: 10.6084/m9.figshare.6736934.v1
title: Marchantia inflexa fluctuating sexual dimorphism

description: This item includes data on recovery from dehydration treatment for the dehydration tolerant tropical liverwort <i>Marchantia inflexa</i>. Data characterizing the environmental conditions at field sites are also included.
DOI: 10.6084/m9.figshare.6736754.v1
title: DataExtract

description: data extract of 'Software Change Proneness Prediction Through Combination of Bagging and Re-sampling Methods'
DOI: 10.6084/m9.figshare.6736751.v1
title: data

description: The data of 'Software Change Proneness Prediction Through Combination of Bagging and Re-sampling Methods'
DOI: 10.6084/m9.figshare.6736586
title: Supplementary Material for: Adenine-Induced Chronic Renal Failure in Rats: A Model of Chronic Renocardiac Syndrome with Left Ventricular Diastolic Dysfunction but Preserved Ejection Fraction

description: <b><i>Background/Aims:</i></b> Cardiovascular disease is the major cause of death in patients with chronic kidney disease (CKD). Rats with adenine-induced chronic renal failure (ACRF) develop severe renal insufficiency and metabolic abnormalities that closely resemble those in patients with uremia. The aim of the present study was to determine left ventricular (LV) morphology and function in rats with ACRF. <b><i>Methods:</i></b> Male Sprague-Dawley rats received either chow containing adenine or were pair-fed an identical diet without adenine (controls, C). After 9-13 weeks animals were anesthetized with isoflurane and cardiac function was assessed both by echocardiography and by LV catheterization. <b><i>Results:</i></b> Rats with ACRF showed increases in serum creatinine (323±107 vs. 33±5 µM, P&lt; 0.05), mean arterial pressure (115±6 vs. 106±7 mmHg, P&lt; 0.05) and LV weight (3.4±0.3 vs. 2.5±0.2 mg/kg, P&lt; 0.05) vs. controls. Rats with ACRF had reduced early diastolic tissue Doppler velocities in the LV, enlarged left atrial diameter (4.8±0.8 vs. 3.5±0.4 mm, P&lt; 0.05) and elevated LV end-diastolic pressure (15±5 vs. 8±1 mmHg, P&lt; 0.01). Cardiac output was increased in ACRF rats (211±66 vs. 149±24 ml/min, P&lt; 0.05) and systolic function preserved. In the LV of ACRF rats there were statistically significant (P&lt; 0.05) increases in cardiomyocyte diameter, proliferation and apoptosis, while there was no difference between groups in fibrosis. <b><i>Conclusion:</i></b> Rats with ACRF develop LV hypertrophy and diastolic dysfunction while systolic performance was preserved. There was an increased hypertrophy and apoptosis of cardiomyocytes in the LV of ACRF rats. The cardiac abnormalities in ACRF rats resemble those in patients with CKD in which heart failure with preserved ejection fraction is common. Hence, this experimental model is well suited for studying pathophysiological mechanisms in chronic renocardiac syndromes.
DOI: 10.6084/m9.figshare.6736586.v1
title: Supplementary Material for: Adenine-Induced Chronic Renal Failure in Rats: A Model of Chronic Renocardiac Syndrome with Left Ventricular Diastolic Dysfunction but Preserved Ejection Fraction

description: <b><i>Background/Aims:</i></b> Cardiovascular disease is the major cause of death in patients with chronic kidney disease (CKD). Rats with adenine-induced chronic renal failure (ACRF) develop severe renal insufficiency and metabolic abnormalities that closely resemble those in patients with uremia. The aim of the present study was to determine left ventricular (LV) morphology and function in rats with ACRF. <b><i>Methods:</i></b> Male Sprague-Dawley rats received either chow containing adenine or were pair-fed an identical diet without adenine (controls, C). After 9-13 weeks animals were anesthetized with isoflurane and cardiac function was assessed both by echocardiography and by LV catheterization. <b><i>Results:</i></b> Rats with ACRF showed increases in serum creatinine (323±107 vs. 33±5 µM, P&lt; 0.05), mean arterial pressure (115±6 vs. 106±7 mmHg, P&lt; 0.05) and LV weight (3.4±0.3 vs. 2.5±0.2 mg/kg, P&lt; 0.05) vs. controls. Rats with ACRF had reduced early diastolic tissue Doppler velocities in the LV, enlarged left atrial diameter (4.8±0.8 vs. 3.5±0.4 mm, P&lt; 0.05) and elevated LV end-diastolic pressure (15±5 vs. 8±1 mmHg, P&lt; 0.01). Cardiac output was increased in ACRF rats (211±66 vs. 149±24 ml/min, P&lt; 0.05) and systolic function preserved. In the LV of ACRF rats there were statistically significant (P&lt; 0.05) increases in cardiomyocyte diameter, proliferation and apoptosis, while there was no difference between groups in fibrosis. <b><i>Conclusion:</i></b> Rats with ACRF develop LV hypertrophy and diastolic dysfunction while systolic performance was preserved. There was an increased hypertrophy and apoptosis of cardiomyocytes in the LV of ACRF rats. The cardiac abnormalities in ACRF rats resemble those in patients with CKD in which heart failure with preserved ejection fraction is common. Hence, this experimental model is well suited for studying pathophysiological mechanisms in chronic renocardiac syndromes.
DOI: 10.6084/m9.figshare.6736481
title: Mutations in cytochrome b confer maternally inherited cross-resistance between acequinocyl and bifenazate

description: The bifenazate resistant Tetranychus urticae koch strains: BL2 and Wasatch were crossed to generate resistant and susceptible F1 crossings. The crossings and parental strains were tested for acequinocyl resistance. This was done by determining the LC<sub>50</sub> values. <br><br>The average mortality per concentration per strain and crossing was put in a graph and compared to determine if the resistance was maternally inherited.<br><br>Cytochrome b of BL2 mites was sequenced to find 2 mutations causing bifenazate resistance and cross-resistance to acequinocyl: G126S and A133T.
DOI: 10.6084/m9.figshare.6736481.v1
title: Mutations in cytochrome b confer maternally inherited cross-resistance between acequinocyl and bifenazate

description: The bifenazate resistant Tetranychus urticae koch strains: BL2 and Wasatch were crossed to generate resistant and susceptible F1 crossings. The crossings and parental strains were tested for acequinocyl resistance. This was done by determining the LC<sub>50</sub> values. <br><br>The average mortality per concentration per strain and crossing was put in a graph and compared to determine if the resistance was maternally inherited.<br><br>Cytochrome b of BL2 mites was sequenced to find 2 mutations causing bifenazate resistance and cross-resistance to acequinocyl: G126S and A133T.
DOI: 10.6084/m9.figshare.6736331
title: The subset of patients with acute heart failure able to secrete relaxin-2 at pregnancy concentrations could have a longer survival: a pilot study

description: <b>Objective:</b> To investigate how many patients with acute heart failure (AHF) hypersecrete relaxin-2 concentrations similar to those of pregnant women and determine their long-term outcome. <b>Methods:</b> In consecutive AHF patients relaxin-2 was quantified by ELISA sandwich method. Patients were divided into pregnancy-like group (PLG, relaxin-2 ≥ 500 pg/mL) and control group (CG, relaxin-2 10 days), combined endpoint (death, rehospitalisation, ED revisit) 30 days after discharge, and 30-day, one-year and three-year death rates. <b>Results</b>: We included 814 patients [81 (SD = 9) years; 53.0% women] followed during 1.9 (SD 2.8) years; 517 (63.5%) died. Twenty patients (2.5%) formed the PLG (median relaxin-2 = 1459 pg/mL; IQR = 1722) and 794 the CG (median = 26; IQR = 44). There was no interaction with variables included on adjustment (age, sex, ischaemic cardiomyopathy, NT-proBNP, glycaemia, and sodium). PLG patients did not have better short-term secondary endpoints, but did show a significantly lower three-year mortality [OR<sub>adjusted</sub> = 0.17 (0.05–0.5), <i>p</i> = 0.003]. <b>Conclusions:</b> The small proportion of AHF patients achieving relaxin-2 concentrations similar to those observed in pregnancy may survive longer.