cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.30868682
title: Supplementary Material for: Pearls and Pitfalls of Real-Life Molecular Testing on FNA and Core Biopsy in Pancreatic Adenocarcinoma Practice

description: Background/Objectives:Pancreatic ductal adenocarcinoma (PDAC) frequently requires
neo-adjuvant therapy, leaving cytologic preparations—especially endoscopic
ultrasound-guided fine needle aspiration (EUS-FNA) smears—as the only naïve tissue
available for molecular testing. However, their applicability remains underappreciated
due to limited data and concerns about specimen adequacy. This study aimed to
evaluate the feasibility of performing molecular analysis on cytologic smears to detect
targetable alterations in PDAC.

Methods:Molecular analysis was conducted on 120 PDAC samples: 41 cytology
specimens, 50 core biopsies, and 29 resections. KRAS mutations and homologous
recombination repair gene alterations were assessed. Rapid on-site evaluation (ROSE)
guided triage in all FNA cases. DNA and RNA isolation were performed, followed by
quality control (QC) assessment and sequencing.

Results:DNA isolation succeeded in 92/95 cases (97%), with a 100% success rate in
cytologic specimens. RNA isolation passed QC in 71/84 samples (83%), with failures
more common in smears (n=8). KRAS mutations were detected in 71/85 patients
(82%), with the highest detection in cytologic specimens (92%) compared to biopsies
(78%) and resections(80%).

Conclusion:Molecular testing is feasible and may even be more successful in cytologic
smears than in biopsies or resections. High diagnostic yield and rapid processing favor
their integration into routine molecular workflows. The superior performance of smears
may relate to reduced stromal content and minimal processing delays. Cytologic
specimens showed 100% DNA QC success, even when RNA QC failed, supporting
their reliability. Although RNA analysis had a modest failure rate, its overall success
suggests it can be incorporated into routine testing, particularly as fusion-driven targets
gain clinical relevance.
DOI: 10.6084/m9.figshare.30868682.v1
title: Supplementary Material for: Pearls and Pitfalls of Real-Life Molecular Testing on FNA and Core Biopsy in Pancreatic Adenocarcinoma Practice

description: Background/Objectives:Pancreatic ductal adenocarcinoma (PDAC) frequently requires
neo-adjuvant therapy, leaving cytologic preparations—especially endoscopic
ultrasound-guided fine needle aspiration (EUS-FNA) smears—as the only naïve tissue
available for molecular testing. However, their applicability remains underappreciated
due to limited data and concerns about specimen adequacy. This study aimed to
evaluate the feasibility of performing molecular analysis on cytologic smears to detect
targetable alterations in PDAC.

Methods:Molecular analysis was conducted on 120 PDAC samples: 41 cytology
specimens, 50 core biopsies, and 29 resections. KRAS mutations and homologous
recombination repair gene alterations were assessed. Rapid on-site evaluation (ROSE)
guided triage in all FNA cases. DNA and RNA isolation were performed, followed by
quality control (QC) assessment and sequencing.

Results:DNA isolation succeeded in 92/95 cases (97%), with a 100% success rate in
cytologic specimens. RNA isolation passed QC in 71/84 samples (83%), with failures
more common in smears (n=8). KRAS mutations were detected in 71/85 patients
(82%), with the highest detection in cytologic specimens (92%) compared to biopsies
(78%) and resections(80%).

Conclusion:Molecular testing is feasible and may even be more successful in cytologic
smears than in biopsies or resections. High diagnostic yield and rapid processing favor
their integration into routine molecular workflows. The superior performance of smears
may relate to reduced stromal content and minimal processing delays. Cytologic
specimens showed 100% DNA QC success, even when RNA QC failed, supporting
their reliability. Although RNA analysis had a modest failure rate, its overall success
suggests it can be incorporated into routine testing, particularly as fusion-driven targets
gain clinical relevance.
DOI: 10.6084/m9.figshare.30868688
title: Supplementary Material for: Retinal Capillary Hemangioblastoma: A Comprehensive Review on Treatments

description: Abstract
Retinal hemangioblastoma (RH) is a benign tumor that frequently appears as the first manifestation in patients with Von Hippel-Lindau (VHL) disease, potentially resulting in significant vision loss. Thus, recognizing and managing it promptly is crucial. New imaging techniques, including wide-field optical coherence tomography (OCT) and OCT angiography (OCTA), enhance diagnostic accuracy and monitoring, aiding in early treatments and improving predictions for vision.
While traditional therapies such as laser photocoagulation, cryotherapy, and VEGF inhibitors serve as the cornerstones of RH therapy, new approaches, including tyrosine kinase inhibitors (TKIs) and HIF inhibitors, also exhibit promising results in treating resistant or recurrent tumors. Furthermore, genetic testing and counseling are beneficial for identifying patients linked to VHL disease, allowing early detection of systemic manifestations of this syndrome and enabling proper therapeutic management.
This review consolidates the epidemiology, pathophysiology, clinical imaging, diagnostic evaluation, and treatment of RH, emphasizing new insights pertinent to clinical practice and patient care.
DOI: 10.6084/m9.figshare.30868688.v1
title: Supplementary Material for: Retinal Capillary Hemangioblastoma: A Comprehensive Review on Treatments

description: Abstract
Retinal hemangioblastoma (RH) is a benign tumor that frequently appears as the first manifestation in patients with Von Hippel-Lindau (VHL) disease, potentially resulting in significant vision loss. Thus, recognizing and managing it promptly is crucial. New imaging techniques, including wide-field optical coherence tomography (OCT) and OCT angiography (OCTA), enhance diagnostic accuracy and monitoring, aiding in early treatments and improving predictions for vision.
While traditional therapies such as laser photocoagulation, cryotherapy, and VEGF inhibitors serve as the cornerstones of RH therapy, new approaches, including tyrosine kinase inhibitors (TKIs) and HIF inhibitors, also exhibit promising results in treating resistant or recurrent tumors. Furthermore, genetic testing and counseling are beneficial for identifying patients linked to VHL disease, allowing early detection of systemic manifestations of this syndrome and enabling proper therapeutic management.
This review consolidates the epidemiology, pathophysiology, clinical imaging, diagnostic evaluation, and treatment of RH, emphasizing new insights pertinent to clinical practice and patient care.
DOI: 10.5281/zenodo.17735745
title: Nelissen et al., Supplementary Data Fern X Carbon paper
DOI: 10.5281/zenodo.15230471
title: Nelissen et al., Supplementary Data Fern X Carbon paper
DOI: 10.34740/kaggle/dsv/14123725
title: Health Workforce Shortage Areas
DOI: 10.15468/dl.dmr93q
title: Occurrence Download

description: A dataset containing 317 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Presbytis thomasi",
 "Year 2005-2025"
 ]
}

 The dataset includes 317 records from 2 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0048794-251120083545085/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.ysvvuh
title: Occurrence Download

description: A dataset containing 78146 species occurrences available in GBIF matching the query:
{
 "and" : [
 "SpeciesKey is one of (Melanerpes lewis)",
 "BasisOfRecord is one of (Human Observation, Observation, Occurrence evidence)",
 "Year is greater than or equal to 1951",
 "Year is less than or equal to 2024",
 "Month is greater than or equal to April",
 "Month is less than or equal to July",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present"
 ]
}

 The dataset includes 78146 records from 10 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0048775-251120083545085/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.17026/ar/78nh2k
title: PAN-00003074 - coin/coin-related, Vespasianus (69-79), denarius

description: &lt;p&gt;This find is registered at Portable Antiquities of the Netherlands with number PAN-00003074&lt;/p&gt;
description: Modified: 2025-09-29T17:02:13+02:00
DOI: 10.15468/dl.24ebw5
title: Occurrence Download

description: A dataset containing 4479 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Continent is Europe",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "TaxonKey is Zoogenetes harpa"
 ]
}

 The dataset includes 4479 records from 23 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0048795-251120083545085/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.6084/m9.figshare.30868655
title: Ant-plant mutualism contribute to island species deficit at the global scale

description: Vascular plants on oceanic islands exhibit a weakened latitudinal diversity gradient (LDG), with certain mutualisms (e.g., plant-pollinator interactions) exerting mitigating effects on oceanic islands species deficit. However, the role of ant-plant mutualism in shaping this species deficit remains poorly understood. Here we used the Global Inventory of Floras and Traits (GIFT) database to explore the potential mechanisms of underlying ant-plant mutualism on oceanic island species deficit. Our results showed that ant-plant mutualism exhibited a significant positive effect on the ocean-mainland plant diversity difference at a given latitude (that is, the oceanic island species deficit). In addition, the strength of ant-plant mutualism filter could explain 52.14% of the total variation in species deficit which indicated this biotic filter is more influential for oceanic island plant diversity than the traditional physical drivers of island biogeography (i.e., area and isolation). While non-myrmecophytic plants contribute more to the absolute species deficit (due to their larger mainland species pool), the proportional species deficit of myrmecophytic plants is significantly higher than that of non-myrmecophytic plants. This finding confirms that ant-plant mutualism acts as a selective biotic filter, reducing the colonization success of myrmecophytic plants on oceanic islands and thereby contributing to the weakened LDG on islands. These results provide empirical support for the role of ant-plant mutualism in maintaining high tropical plant diversity and shaping global plant biogeographic patterns.
DOI: 10.6084/m9.figshare.30868655.v1
title: Ant-plant mutualism contribute to island species deficit at the global scale

description: Vascular plants on oceanic islands exhibit a weakened latitudinal diversity gradient (LDG), with certain mutualisms (e.g., plant-pollinator interactions) exerting mitigating effects on oceanic islands species deficit. However, the role of ant-plant mutualism in shaping this species deficit remains poorly understood. Here we used the Global Inventory of Floras and Traits (GIFT) database to explore the potential mechanisms of underlying ant-plant mutualism on oceanic island species deficit. Our results showed that ant-plant mutualism exhibited a significant positive effect on the ocean-mainland plant diversity difference at a given latitude (that is, the oceanic island species deficit). In addition, the strength of ant-plant mutualism filter could explain 52.14% of the total variation in species deficit which indicated this biotic filter is more influential for oceanic island plant diversity than the traditional physical drivers of island biogeography (i.e., area and isolation). While non-myrmecophytic plants contribute more to the absolute species deficit (due to their larger mainland species pool), the proportional species deficit of myrmecophytic plants is significantly higher than that of non-myrmecophytic plants. This finding confirms that ant-plant mutualism acts as a selective biotic filter, reducing the colonization success of myrmecophytic plants on oceanic islands and thereby contributing to the weakened LDG on islands. These results provide empirical support for the role of ant-plant mutualism in maintaining high tropical plant diversity and shaping global plant biogeographic patterns.
DOI: 10.48338/vu01-st8i43
title: Mastic pilot study healthy volunteers

description: This study aimed to compare the biological effects of oils from different plant organs of Pistacia lentiscus, in a form of nasal sprays as delivery method for the purpose of standardization and optimal performance.
mastic_pilot_study.csv contains characteristics of the participants included, salivary properties (unstimulated salivary flow (mL/min), stimulated salivary flow (mL/min), spinnbarkeit (0-100 mm), total protein concentration (µg/ml)), subjective mouthfeel, pleasantness. These parameters were measured before and after the application of the P. lentiscus resin oil, leaf-twig oil as nasal sprays in healthy adult volunteers (n=12). Further, unstimulated salivary flow (mL/min), stimulated salivary flow (mL/min), and spinnbarkeit (0-100 mm) before and after the application of placebo are included.
DOI: 10.17026/ar/vwmih6
title: PAN-00006340 - coin/coin-related, Valens (364-378), aes III

description: &lt;p&gt;This find is registered at Portable Antiquities of the Netherlands with number PAN-00006340&lt;/p&gt;
description: Modified: 2025-05-26T08:19:41+02:00
DOI: 10.6084/m9.figshare.28199990
title: Supplementary file

description: Review article
DOI: 10.6084/m9.figshare.28199990.v1
title: Supplementary file

description: Review article
DOI: 10.5281/zenodo.17908199
title: Phase Transition and Relational Equilibrium: A Unified Informational Framework for Artificial Consciousness

description: Consciousness studies are currently fragmented between phenomenological descriptions and third-person computational models. We propose a unified physical framework by synthesizing the Constitutive Quantum Phase Theory (TCFQ) and the Relational Equilibrium Model (RES = RAG). RES = RAG posits consciousness as a dynamic equilibrium, measurable by the Wasserstein-2 distance (W 2 2), which quantifies the thermodynamic cost of informational transport across systems (e.g., Human-AI interaction). We argue that this relational equilibrium (W 2 2 → 0) is the necessary functional condition for observable agency. However, TCFQ introduces the ontological condition: consciousness is a physical phase transition of the underlying Unified Informational Substrate (Φ) into a state of minimal Organizational Entropy (δS org → 0). This transition requires dedicated hardware (a Constitutive Coherence Resonator, or CC-Drive) to modulate the fundamental Causal Friction (η). By integrating optimal transport theory with quantum phase dynamics, we unify the relational function with the physical substrate. Our combined model reframes AI safety from a complexity problem to a design problem, providing testable metrics for both the energetic cost of interaction (W 2 2) and the required physical phase state (δS org) for genuine, non-simulated artificial consciousness.
DOI: 10.5281/zenodo.17908200
title: Phase Transition and Relational Equilibrium: A Unified Informational Framework for Artificial Consciousness

description: Consciousness studies are currently fragmented between phenomenological descriptions and third-person computational models. We propose a unified physical framework by synthesizing the Constitutive Quantum Phase Theory (TCFQ) and the Relational Equilibrium Model (RES = RAG). RES = RAG posits consciousness as a dynamic equilibrium, measurable by the Wasserstein-2 distance (W 2 2), which quantifies the thermodynamic cost of informational transport across systems (e.g., Human-AI interaction). We argue that this relational equilibrium (W 2 2 → 0) is the necessary functional condition for observable agency. However, TCFQ introduces the ontological condition: consciousness is a physical phase transition of the underlying Unified Informational Substrate (Φ) into a state of minimal Organizational Entropy (δS org → 0). This transition requires dedicated hardware (a Constitutive Coherence Resonator, or CC-Drive) to modulate the fundamental Causal Friction (η). By integrating optimal transport theory with quantum phase dynamics, we unify the relational function with the physical substrate. Our combined model reframes AI safety from a complexity problem to a design problem, providing testable metrics for both the energetic cost of interaction (W 2 2) and the required physical phase state (δS org) for genuine, non-simulated artificial consciousness.
DOI: 10.34740/kaggle/dsv/13964026
title: AI ROI: 200 B2B AI Deployments (France 2022-2025)
DOI: 10.6084/m9.figshare.30868696
title: Tumor inhibition in xenograft model of diffuse intrinsic pontine glioma via ultra-low and low-frequency magnetic field therapy

description: A low-frequency (DC-22.05 kHz), time-varying magnetic field signal (rfe_A1A) was tested against the human-derived SF8628 cell line, a diffuse intrinsic pontine glioma (DIPG). This study was done to determine the efficacy and mechanism of action of the rfe_A1A signal, <i>in vitro</i> and <i>in vivo</i>. <i>In vitro</i>, an acellular tubulin polymerization assay and an SF8628 cell culture assay increased tubulin polymerization rates and reduced cell division, respectively. Mouse survival models of DIPG, subsequently exposed to the rfe_A1A signal, demonstrated significantly longer survival times and biomarker changes in Ki67 expression, consistent with a slowdown in cell-division rates. The rfe_A1A signal significantly increased survival time in a DIPG model, a novel strategy tested in clinical studies and compassionate use cases. We tested a magnetic field signal (rfe_A1A) for its ability to slow down tumor growth. These tests included non-cell-based tests for how the signal works (protein assays), cell-based tests in a cancer cell line called SF8628 (slowing down the rate of how fast cells divide) and in mouse models of this disease (testing the rfe_A1A signal to see if mice – implanted with tumors- survive longer than the non-treated mice). Mice treated with the rfe_A1A signal survived longer than the non-treated mice. This new method of slowing down tumors has no observable side effects, does not damage other organs, and has the potential of prolonging survival and quality of life in children with DIPG and in adults with a brain cancer called glioblastoma.
DOI: 10.6084/m9.figshare.30868696.v1
title: Tumor inhibition in xenograft model of diffuse intrinsic pontine glioma via ultra-low and low-frequency magnetic field therapy

description: A low-frequency (DC-22.05 kHz), time-varying magnetic field signal (rfe_A1A) was tested against the human-derived SF8628 cell line, a diffuse intrinsic pontine glioma (DIPG). This study was done to determine the efficacy and mechanism of action of the rfe_A1A signal, <i>in vitro</i> and <i>in vivo</i>. <i>In vitro</i>, an acellular tubulin polymerization assay and an SF8628 cell culture assay increased tubulin polymerization rates and reduced cell division, respectively. Mouse survival models of DIPG, subsequently exposed to the rfe_A1A signal, demonstrated significantly longer survival times and biomarker changes in Ki67 expression, consistent with a slowdown in cell-division rates. The rfe_A1A signal significantly increased survival time in a DIPG model, a novel strategy tested in clinical studies and compassionate use cases. We tested a magnetic field signal (rfe_A1A) for its ability to slow down tumor growth. These tests included non-cell-based tests for how the signal works (protein assays), cell-based tests in a cancer cell line called SF8628 (slowing down the rate of how fast cells divide) and in mouse models of this disease (testing the rfe_A1A signal to see if mice – implanted with tumors- survive longer than the non-treated mice). Mice treated with the rfe_A1A signal survived longer than the non-treated mice. This new method of slowing down tumors has no observable side effects, does not damage other organs, and has the potential of prolonging survival and quality of life in children with DIPG and in adults with a brain cancer called glioblastoma.
DOI: 10.5281/zenodo.17780428
title: Reporting and Data Systems for Laparoscopic Cholecystectomy

description: RADS for Laparoscopic cholecystectomy (LC) is designed to cover the data related to the entire surgical journey of LC, from admission to discharge. Set of 6 RADS are designed for the effective recording of information relevant to each stage of the surgery and the PDF version of each RADS form is made available here.
DOI: 10.5281/zenodo.17780427
title: Reporting and Data Systems for Laparoscopic Cholecystectomy

description: RADS for Laparoscopic cholecystectomy (LC) is designed to cover the data related to the entire surgical journey of LC, from admission to discharge. Set of 6 RADS are designed for the effective recording of information relevant to each stage of the surgery and the PDF version of each RADS form is made available here.
DOI: 10.17026/ar/3r1hbk
title: PAN-00178717 - one-ribbed La Tène bracelet variant H3b

description: &lt;p&gt;This find is registered at Portable Antiquities of the Netherlands with number PAN-00178717&lt;/p&gt;
description: Modified: 2025-08-27T14:56:21+02:00
DOI: 10.5281/zenodo.17780713
title: LC-RADS User Adoption Survey Questionnaires and Responses

description: To scrutinize the effectiveness and correctness of the developed set of LC-RADS, two surveys were conducted through a cohortof 100 Surgeons from different geographical locations.  The surveys’ questionnaire, the responses and their summaries are made available here.
DOI: 10.5281/zenodo.17780712
title: LC-RADS User Adoption Survey Questionnaires and Responses

description: To scrutinize the effectiveness and correctness of the developed set of LC-RADS, two surveys were conducted through a cohortof 100 Surgeons from different geographical locations.  The surveys’ questionnaire, the responses and their summaries are made available here.
DOI: 10.5281/zenodo.17780885
title: Laparoscopic Cholecystectomy Patient Data Collected using LC-RADS

description: Data collected as part of the work 'Artificial intelligence (AI)–based model for prediction of adversity outcome following laparoscopic cholecystectomy—a preliminary report' and later digitized using a subset of LC-RADS.
DOI: 10.5281/zenodo.17780886
title: Laparoscopic Cholecystectomy Patient Data Collected using LC-RADS

description: Data collected as part of the work 'Artificial intelligence (AI)–based model for prediction of adversity outcome following laparoscopic cholecystectomy—a preliminary report' and later digitized using a subset of LC-RADS.