cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.10291634.v1
title: Darunavir/cobicistat/emtricitabine/tenofovir alafenamide in treatment-naïve patients with HIV-1: subgroup analyses of the phase 3 AMBER study

description: <b>Background</b>: The once-daily, single-tablet regimen darunavir/cobicistat/emtricitabine/tenofovir alafenamide (D/C/F/TAF) 800/150/200/10 mg is approved for the treatment of HIV-1 infection. The 48-week efficacy and safety of D/C/F/TAF versus darunavir/cobicistat + emtricitabine/tenofovir disoproxil fumarate (control) in treatment-naïve adults were demonstrated in the phase 3 AMBER study. <b>Objective</b>: To describe AMBER outcomes across patient subgroups based on demographic and clinical characteristics at baseline. <b>Methods</b>: AMBER patients had viral load (VL) ≥1000 copies/mL, CD4<sup>+</sup> cell count &gt;50 cells/µL, and genotypic susceptibility to darunavir, emtricitabine, and tenofovir. Primary endpoint was the proportion of patients with virologic response (VL &lt;50 copies/mL; FDA snapshot). Safety was assessed by adverse events, estimated glomerular filtration rate (cystatin C; eGFR<sub>cystC</sub>), and bone mineral density. Outcomes were assessed by age (≤/&gt;50 years), gender, race (black/non-black), baseline VL (≤/&gt;100,000 copies/mL), baseline CD4<sup>+</sup> cell count ( <b>Results</b>: For the 725 AMBER patients (D/C/F/TAF: 362; control: 363), virologic response rates at week 48 were similar with D/C/F/TAF (91%) and control (88%), and this was consistent across all subgroups. Adverse event rates were similar in both arms, although numerically higher among patients &gt;50 years and women, relative to their comparator groups, regardless of treatment arm (notably, sample sizes were small for patients &gt;50 years and women). Improvements in eGFR<sub>cystC</sub> and stable bone mineral density were observed with D/C/F/TAF overall, and results were generally consistent across subgroups. <b>Conclusions</b>: For treatment-naïve patients in AMBER, initiating therapy with the D/C/F/TAF single-tablet regimen was an effective and well-tolerated option, regardless of demographic or clinical characteristics. <b>Trial registration:</b>ClinicalTrials.gov identifier: NCT02431247.
DOI: 10.6084/m9.figshare.10291178
title: Supplementary Material for: Glucose Fluctuations Promote Aortic Fibrosis through the ROS/p38 MAPK/Runx2 Signaling Pathway

description: <b><i>Aim:</i></b> Glucose fluctuations may be responsible for, or further the onset of arterial hypertension, but the exact mechanisms remain unclear. The purpose of this study was to investigate the mechanisms behind and related to aortic fibrosis and aortic stiffening induced by glucose fluctuations. <b><i>Methods:</i></b> Sprague-Dawley rats were injected with streptozotocin (STZ) and randomly divided into three treatment groups: controlled STZ-induced diabetes (C-STZ); uncontrolled STZ-induced diabetes (U-STZ); and STZ-induced diabetes with glucose fluctuations (STZ-GF). After 3 weeks, rat blood pressure (BP) was tested, and aortic fibrosis was detected by using the Masson trichrome staining technique. Levels of p38 mitogen-activated protein kinase (p38 MAPK), runt-related transcription factor 2 (Runx2), collagen type 1 (collagen I), and NADPH oxidases were determined by Western blot.<i></i>Rat vascular smooth muscle cells in vitro were used to explore underlying mechanisms. <b><i>Results:</i></b> The systolic BP of diabetic rats in the C-STZ, U-STZ, and STZ-GF groups was 127.67 ± 6.53, 150.03 ± 5.24, and 171.63 ± 3.53 mm Hg, respectively (<i>p</i>&lt; 0.05). The mean BP of diabetic rats in the three groups was 91.20 ± 10.07, 117.29 ± 4.28, and 140.58 ± 2.14 mm Hg, respectively (<i>p</i>&lt; 0.05). The diastolic BP of diabetic rats in the three groups was 73.20 ± 12.63, 101.93 ± 5.79, and 125.37 ± 4.62 mm Hg, respectively (<i>p</i>&lt; 0.05). The ratios of fibrosis areas in the aortas of the three groups were 11.85 ± 1.23, 29.00 ± 0.87, and 48.36 ± 0.55, respectively (<i>p</i>&lt; 0.05). The expressions of p38 MAPK, Runx2, and collagen I were significantly increased in the STZ-GF group. In vitro, applications of inhibitors of reactive oxygen species (ROS) and p38 MAPK successfully reversed glucose fluctuations that would have possibly induced aortic fibrosis. <b><i>Conclusions:</i></b> Blood glucose fluctuations aggravate aortic fibrosis via affecting the ROS/p38 MAPK /Runx2 signaling pathway.
DOI: 10.5517/ccdc.csd.cc21wt81
title: CCDC 1903563: Experimental Crystal Structure Determination

description: Related Article: Nico Giordano, Christine M. Beavers, Konstantin V. Kamenev, William G. Marshall, Stephen A. Moggach, Simon D. Patterson, Simon J. Teat, John E. Warren, Peter A. Wood, Simon Parsons|2019|CrystEngComm|21|4444|doi:10.1039/C9CE00388F
description: Related Article: Nico Giordano, Simon Parsons|2019|Thesis|||
DOI: 10.5517/ccdc.csd.cc21wtb3
title: CCDC 1903565: Experimental Crystal Structure Determination

description: Related Article: Nico Giordano, Christine M. Beavers, Konstantin V. Kamenev, William G. Marshall, Stephen A. Moggach, Simon D. Patterson, Simon J. Teat, John E. Warren, Peter A. Wood, Simon Parsons|2019|CrystEngComm|21|4444|doi:10.1039/C9CE00388F
description: Related Article: Nico Giordano, Simon Parsons|2019|Thesis|||
DOI: 10.6084/m9.figshare.10291178.v1
title: Supplementary Material for: Glucose Fluctuations Promote Aortic Fibrosis through the ROS/p38 MAPK/Runx2 Signaling Pathway

description: <b><i>Aim:</i></b> Glucose fluctuations may be responsible for, or further the onset of arterial hypertension, but the exact mechanisms remain unclear. The purpose of this study was to investigate the mechanisms behind and related to aortic fibrosis and aortic stiffening induced by glucose fluctuations. <b><i>Methods:</i></b> Sprague-Dawley rats were injected with streptozotocin (STZ) and randomly divided into three treatment groups: controlled STZ-induced diabetes (C-STZ); uncontrolled STZ-induced diabetes (U-STZ); and STZ-induced diabetes with glucose fluctuations (STZ-GF). After 3 weeks, rat blood pressure (BP) was tested, and aortic fibrosis was detected by using the Masson trichrome staining technique. Levels of p38 mitogen-activated protein kinase (p38 MAPK), runt-related transcription factor 2 (Runx2), collagen type 1 (collagen I), and NADPH oxidases were determined by Western blot.<i></i>Rat vascular smooth muscle cells in vitro were used to explore underlying mechanisms. <b><i>Results:</i></b> The systolic BP of diabetic rats in the C-STZ, U-STZ, and STZ-GF groups was 127.67 ± 6.53, 150.03 ± 5.24, and 171.63 ± 3.53 mm Hg, respectively (<i>p</i>&lt; 0.05). The mean BP of diabetic rats in the three groups was 91.20 ± 10.07, 117.29 ± 4.28, and 140.58 ± 2.14 mm Hg, respectively (<i>p</i>&lt; 0.05). The diastolic BP of diabetic rats in the three groups was 73.20 ± 12.63, 101.93 ± 5.79, and 125.37 ± 4.62 mm Hg, respectively (<i>p</i>&lt; 0.05). The ratios of fibrosis areas in the aortas of the three groups were 11.85 ± 1.23, 29.00 ± 0.87, and 48.36 ± 0.55, respectively (<i>p</i>&lt; 0.05). The expressions of p38 MAPK, Runx2, and collagen I were significantly increased in the STZ-GF group. In vitro, applications of inhibitors of reactive oxygen species (ROS) and p38 MAPK successfully reversed glucose fluctuations that would have possibly induced aortic fibrosis. <b><i>Conclusions:</i></b> Blood glucose fluctuations aggravate aortic fibrosis via affecting the ROS/p38 MAPK /Runx2 signaling pathway.
DOI: 10.5517/ccdc.csd.cc21wtc4
title: CCDC 1903566: Experimental Crystal Structure Determination

description: Related Article: Nico Giordano, Christine M. Beavers, Konstantin V. Kamenev, William G. Marshall, Stephen A. Moggach, Simon D. Patterson, Simon J. Teat, John E. Warren, Peter A. Wood, Simon Parsons|2019|CrystEngComm|21|4444|doi:10.1039/C9CE00388F
description: Related Article: Nico Giordano, Simon Parsons|2019|Thesis|||
DOI: 10.5517/ccdc.csd.cc21wtlc
title: CCDC 1903573: Experimental Crystal Structure Determination

description: Related Article: Nico Giordano, Christine M. Beavers, Konstantin V. Kamenev, William G. Marshall, Stephen A. Moggach, Simon D. Patterson, Simon J. Teat, John E. Warren, Peter A. Wood, Simon Parsons|2019|CrystEngComm|21|4444|doi:10.1039/C9CE00388F
description: Related Article: Nico Giordano, Simon Parsons|2019|Thesis|||
DOI: 10.5517/ccdc.csd.cc21wtmd
title: CCDC 1903574: Experimental Crystal Structure Determination

description: Related Article: Nico Giordano, Christine M. Beavers, Konstantin V. Kamenev, William G. Marshall, Stephen A. Moggach, Simon D. Patterson, Simon J. Teat, John E. Warren, Peter A. Wood, Simon Parsons|2019|CrystEngComm|21|4444|doi:10.1039/C9CE00388F
description: Related Article: Nico Giordano, Simon Parsons|2019|Thesis|||
DOI: 10.5517/ccdc.csd.cc21wtsk
title: CCDC 1903579: Experimental Crystal Structure Determination

description: Related Article: Nico Giordano, Christine M. Beavers, Konstantin V. Kamenev, William G. Marshall, Stephen A. Moggach, Simon D. Patterson, Simon J. Teat, John E. Warren, Peter A. Wood, Simon Parsons|2019|CrystEngComm|21|4444|doi:10.1039/C9CE00388F
description: Related Article: Nico Giordano, Simon Parsons|2019|Thesis|||
DOI: 10.5517/ccdc.csd.cc21wttl
title: CCDC 1903580: Experimental Crystal Structure Determination

description: Related Article: Nico Giordano, Christine M. Beavers, Konstantin V. Kamenev, William G. Marshall, Stephen A. Moggach, Simon D. Patterson, Simon J. Teat, John E. Warren, Peter A. Wood, Simon Parsons|2019|CrystEngComm|21|4444|doi:10.1039/C9CE00388F
description: Related Article: Nico Giordano, Simon Parsons|2019|Thesis|||
DOI: 10.5517/ccdc.csd.cc21wtwn
title: CCDC 1903582: Experimental Crystal Structure Determination

description: Related Article: Nico Giordano, Christine M. Beavers, Konstantin V. Kamenev, William G. Marshall, Stephen A. Moggach, Simon D. Patterson, Simon J. Teat, John E. Warren, Peter A. Wood, Simon Parsons|2019|CrystEngComm|21|4444|doi:10.1039/C9CE00388F
description: Related Article: Nico Giordano, Simon Parsons|2019|Thesis|||
DOI: 10.25505/fiz.icsd.cc23fkhm
title: CSD 1949450: Experimental Crystal Structure Determination

description: Related Article: Markus Nentwig, Lucien Eisenburger, Frank Heinke, Daniel Souchay, Oliver Oeckler|2020|Chem.-Eur.J.|26|10676|doi:10.1002/chem.202000663
DOI: 10.6084/m9.figshare.10290605
title: Supplementary Material for: Assessment of the Corticospinal Tract Profile in Pure Lower Motor Neuron Disease: A Diffusion Tensor Imaging Study

description: <b><i>Aim:</i></b> The aim of this study was to evaluate the corticospinal tract (CST) diffusion profile in pure lower motor neuron disease (pLMND) patients who at baseline did not show any clinical or electrophysiological involvement of upper motor neurons (UMN), and in amyotrophic lateral sclerosis (ALS) patients. <b><i>Materials and Methods:</i></b> Fifteen ALS patients with delayed central motor conduction time (CMCT) and 14 pLMND patients with normal CMCT were enrolled together with 15 healthy controls. Fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD) maps were obtained. The tract profile of CST was reconstructed with the automated fiber quantification tool and its diffusion properties were quantified voxel-by-voxel and then compared pairwise between groups. Moreover, a random forest (RF) classifier was trained to evaluate the ability of CST diffusion metrics in distinguishing pairwise the groups from the controls. <b><i>Results:</i></b> ALS patients presented wide microstructural abnormalities in the entire CST as assessed by FA decrease and RD increase while pLMND patients showed focal FA decrease and a larger AD increase in the cerebral peduncle and posterior limb of the internal capsule in comparison with controls. RF revealed that diffusion tensor imaging (DTI) metrics accurately distinguished ALS patients and pLMND patients from controls (96.67 and 95.71% accuracy, respectively). <b><i>Conclusions:</i></b> Our study demonstrates that the CST was impaired in both ALS and pLMND patients, thus suggesting that DTI metrics are a reliable tool in detecting subtle changes of UMN in pLMND patients, also in the absence of clinical and CMCT abnormalities.
DOI: 10.6084/m9.figshare.10290578
title: Recent life stress predicts blunted acute stress response and the role of executive control

description: The present study examined the associations between recent life stress and responses to acute psychological stress, and how these associations varied with executive control. Heart rate (HR), heart rate variability (HRV), salivary cortisol, and affective states were measured before, during and after the Trier Social Stress Test (TSST), an effective laboratory stressor, in 54 healthy participants, and executive control function was tested with a Go/No-Go task in a neutral context on a different day. The hierarchical multiple regression analysis showed that high frequency of life stress during the last twelve months predicted blunted cardiovascular acute stress response, i.e., smaller HR and HRV reactivity. Moreover, the low executive control group showed a significant association between higher recent life stress and blunted acute stress response, which was not apparent in the high executive control group. The results suggested that greater executive control may benefit us with adaptive acute stress response under recent life stress.HighlightsThe Trier Social Stress Test induces cardiovascular and cortisol responses.Higher life event frequency (LEF) predicts smaller cardiovascular stress response.Executive control plays a role in the link of LEF to stress response. The Trier Social Stress Test induces cardiovascular and cortisol responses. Higher life event frequency (LEF) predicts smaller cardiovascular stress response. Executive control plays a role in the link of LEF to stress response.
DOI: 10.6084/m9.figshare.10290020
title: Craniomandibular osteology of <i>Macrocollum itaquii</i> (Dinosauria: Sauropodomorpha) from the Late Triassic of southern Brazil

description: Several new sauropodomorphs have been described in recent years, including the unaysaurid sauropodomorph <i>Macrocollum itaquii</i> (Late Triassic, Brazil). This study presents a detailed description of the craniomandibular anatomy of <i>M. itaquii</i> based on the holotype, a paratype and a newly referred specimen. A phylogenetic analysis using an updated dataset is performed to test a previous hypothesis regarding the affinities of this taxon and its potential influence in the phylogeny of Triassic and Early Jurassic sauropodomorphs. The taxon is supported as a member of Unaysauridae. This clade is recovered as the basal-most group within Massopoda rather than the sister group to Plateosauria. However, the position of <i>M. itaquii</i> (and unaysaurids) is likely to be highly labile due to specific, transitional aspects of its anatomy. The most recently discovered <i>M. itaquii</i> specimen, in conjunction with other newly discovered specimens, serve to elucidate the transition from slender basal sauropodomorphs to more robust derived members within this group.
DOI: 10.6084/m9.figshare.10290020.v1
title: Craniomandibular osteology of <i>Macrocollum itaquii</i> (Dinosauria: Sauropodomorpha) from the Late Triassic of southern Brazil

description: Several new sauropodomorphs have been described in recent years, including the unaysaurid sauropodomorph <i>Macrocollum itaquii</i> (Late Triassic, Brazil). This study presents a detailed description of the craniomandibular anatomy of <i>M. itaquii</i> based on the holotype, a paratype and a newly referred specimen. A phylogenetic analysis using an updated dataset is performed to test a previous hypothesis regarding the affinities of this taxon and its potential influence in the phylogeny of Triassic and Early Jurassic sauropodomorphs. The taxon is supported as a member of Unaysauridae. This clade is recovered as the basal-most group within Massopoda rather than the sister group to Plateosauria. However, the position of <i>M. itaquii</i> (and unaysaurids) is likely to be highly labile due to specific, transitional aspects of its anatomy. The most recently discovered <i>M. itaquii</i> specimen, in conjunction with other newly discovered specimens, serve to elucidate the transition from slender basal sauropodomorphs to more robust derived members within this group.
DOI: 10.6084/m9.figshare.10289753
title: Radiocarbon Palaeolithic Europe Database v26

description: The database, version 26 (first version was available in2002), contains now <b>13093</b> site forms, (most of them with their geographical coordinates), comprising <b>15500 </b>radiometric data: Conv. <sup>14</sup>C and AMS <sup>14</sup>C (<b>12500 </b>items), TL (<b>1023</b> items), OSL (<b>627</b> items), ESR, Th/U and AAR (<b>2015</b> items) from the European (Russian Siberia included) Lower, Middle and Upper Palaeolithic. All <sup>14</sup>C dates are conventional dates BP. 263 new sites are incorporated and 447 sites have a corrected or an updated content. For citation, please use: Vermeersch, P.M., 2019. <i>Radiocarbon Palaeolithic Europe Database, Version 25</i>. Available at: http://ees.kuleuven.be/geography/projects/14c-palaeolithic/index.html.<b> </b><b></b>
DOI: 10.6084/m9.figshare.10289750
title: Metadata record for: High-resolution behavioral time series of Japanese quail within their social environment

description: This dataset contains key characteristics about the data described in the Data Descriptor High-resolution behavioral time series of Japanese quail within their social environment. <br> Contents: <br> 1. human readable metadata summary table in CSV format 2. machine readable metadata file in JSON format <br> <br> Version 2 was generated when the metadata format was updated from JSON to JSON-LD. This was an automatic process that changed only the format, not the contents, of the metadata.<br>
DOI: 10.6084/m9.figshare.10289753.v1
title: Radiocarbon Palaeolithic Europe Database v26

description: The database, version 26 (first version was available in2002), contains now <b>13093</b> site forms, (most of them with their geographical coordinates), comprising <b>15500 </b>radiometric data: Conv. <sup>14</sup>C and AMS <sup>14</sup>C (<b>12500 </b>items), TL (<b>1023</b> items), OSL (<b>627</b> items), ESR, Th/U and AAR (<b>2015</b> items) from the European (Russian Siberia included) Lower, Middle and Upper Palaeolithic. All <sup>14</sup>C dates are conventional dates BP. 263 new sites are incorporated and 447 sites have a corrected or an updated content. For citation, please use: Vermeersch, P.M., 2019. <i>Radiocarbon Palaeolithic Europe Database, Version 25</i>. Available at: http://ees.kuleuven.be/geography/projects/14c-palaeolithic/index.html.<b> </b><b></b>
DOI: 10.6084/m9.figshare.10289702
title: Molecular species delimitation of reef-building coral genera, <i>Porites</i> and <i>Turbinaria</i> (Anthozoa: Scleractinia), from the intertidal fringing reefs of Gulf of Kutch, India reveals unrecognized diversity

description: Knowledge of extant biodiversity with accurate species boundaries is one of the crucial prerequisites for guiding conservation priorities in the face of global climate change. DNA taxonomy promises to provide a rapid and reliable tool for species delimitation of morphologically challenging taxa, such as reef-building corals. Despite harbouring diverse coral assemblages, molecular studies of hard corals occurring in the seas around India are lacking. The Gulf of Kutch (GoK), located in the north-western part of India, is one such region. Information on coral species inhabiting this unique ecosystem is limited to morphology, which is often highly variable and phenotypically plastic, obscuring species boundaries. Here, we present the first exploration of molecular divergence of hard corals of the GoK in order to identify evolutionarily distinct lineages. Nuclear ribosomal ITS and mitochondrial <i>COI</i> markers were sequenced for samples of dominant genera, <i>Porites</i> and <i>Turbinaria</i> for phylogenetic comparisons with available data from other ecosystems of the world. Five molecular species delimitation methods were applied to the datasets and their performance was evaluated. Our analyses clearly suggest the occurrence of unique genotypes of both these genera in the GoK, unequivocally discerned by all the five methods as well as microskeletal features. This first integrative assessment provides implications for the phylogeny of these genera and identifies previously unrecognized scleractinian species hidden in the GoK ecoregion.
DOI: 10.6084/m9.figshare.10289702.v1
title: Molecular species delimitation of reef-building coral genera, <i>Porites</i> and <i>Turbinaria</i> (Anthozoa: Scleractinia), from the intertidal fringing reefs of Gulf of Kutch, India reveals unrecognized diversity

description: Knowledge of extant biodiversity with accurate species boundaries is one of the crucial prerequisites for guiding conservation priorities in the face of global climate change. DNA taxonomy promises to provide a rapid and reliable tool for species delimitation of morphologically challenging taxa, such as reef-building corals. Despite harbouring diverse coral assemblages, molecular studies of hard corals occurring in the seas around India are lacking. The Gulf of Kutch (GoK), located in the north-western part of India, is one such region. Information on coral species inhabiting this unique ecosystem is limited to morphology, which is often highly variable and phenotypically plastic, obscuring species boundaries. Here, we present the first exploration of molecular divergence of hard corals of the GoK in order to identify evolutionarily distinct lineages. Nuclear ribosomal ITS and mitochondrial <i>COI</i> markers were sequenced for samples of dominant genera, <i>Porites</i> and <i>Turbinaria</i> for phylogenetic comparisons with available data from other ecosystems of the world. Five molecular species delimitation methods were applied to the datasets and their performance was evaluated. Our analyses clearly suggest the occurrence of unique genotypes of both these genera in the GoK, unequivocally discerned by all the five methods as well as microskeletal features. This first integrative assessment provides implications for the phylogeny of these genera and identifies previously unrecognized scleractinian species hidden in the GoK ecoregion.
DOI: 10.6084/m9.figshare.10289750.v2
title: Metadata record for: High-resolution behavioral time series of Japanese quail within their social environment

description: This dataset contains key characteristics about the data described in the Data Descriptor High-resolution behavioral time series of Japanese quail within their social environment. <br> Contents: <br> 1. human readable metadata summary table in CSV format 2. machine readable metadata file in JSON format <br> <br> Version 2 was generated when the metadata format was updated from JSON to JSON-LD. This was an automatic process that changed only the format, not the contents, of the metadata.<br>
DOI: 10.6084/m9.figshare.10289750.v1
title: Metadata record for: High-resolution behavioral time series of Japanese quail within their social environment

description: This dataset contains key characteristics about the data described in the Data Descriptor High-resolution behavioral time series of Japanese quail within their social environment. <br> Contents: <br> 1. human readable metadata summary table in CSV format 2. machine readable metadata file in JSON format
DOI: 10.6084/m9.figshare.10289468
title: Raw data of the experiment from Spider mite mothers adjust reproduction and sons' alternative reproductive tactics to immigrating alien conspecifics

description: Raw data of the experiment
DOI: 10.6084/m9.figshare.10289468.v1
title: Raw data of the experiment from Spider mite mothers adjust reproduction and sons' alternative reproductive tactics to immigrating alien conspecifics

description: Raw data of the experiment
DOI: 10.6084/m9.figshare.10289405
title: T2 spectrum value of rock samples at different periods from Experimental study on repair of fractured rock mass by microbial induction technology

description: T2 spectral value obtained by NMR test