DOI: 10.25550/1-x5k8
title: Gene summary for IRF6

description: ### Genome Browser Links [mm9](http://genome.ucsc.edu/cgi-bin/hgTracks?org=mouse&db=mm9&position=chr1%3A194979306-194998229&refGene=pack&hgFind_matches=NM_016851%2C) | [mm10](http://genome.ucsc.edu/cgi-bin/hgTracks?org=mouse&db=mm10&position=chr1%3A193153112-193172035&refGene=pack&hgFind_matches=NM_016851%2C) | [hg18](http://genome.ucsc.edu/cgi-bin/hgTracks?org=human&db=hg18&position=chr1%3A208025591-208046143&refGene=pack&hgFind_matches=NM_006147%2C) | [hg19](http://genome.ucsc.edu/cgi-bin/hgTracks?org=human&db=hg19&position=chr1%3A209958968-209979520&refGene=pack&hgFind_matches=NM_006147%2C) ### Reference Images | E12.5 | E13.5 | E14.5 | E15.5 | |-------|-------|-------|-------| | ![Image](/hatrac/facebase/genesummaries/Irf6_posterior_E12.5.jpg) | ![Image](/hatrac/facebase/genesummaries/Irf6_posterior_E13.5.jpg) | ![Image](/hatrac/facebase/genesummaries/Irf6_posterior_E14.5.jpg) | ![Image](/hatrac/facebase/genesummaries/Irf6_posterior_E15.5.jpg) | ### Gene expression in the secondary palate _Irf6_ is expressed in the palatal epithelium along the AP axis, including the oral and nasal epithelia and in the MEE. | | E12.5 | E13.5 | E14.5 | E15.5 | |--------|-------|-------|-------|-------| | **Coronal** | ![ImageWithSize](/hatrac/facebase/genesummaries/Irf6_coronal_E12.5.jpg){width=100} | ![ImageWithSize](/hatrac/facebase/genesummaries/Irf6_coronal_E13.5.jpg){width=100} | ![ImageWithSize](/hatrac/facebase/genesummaries/Irf6_coronal_E14.5.jpg){width=100} | ![ImageWithSize](/hatrac/facebase/genesummaries/Irf6_coronal_E15.5.jpg){width=100} | | **Intraoral** | ![ImageWithSize](/hatrac/facebase/genesummaries/Irf6_oral_E12.5.jpg){width=100} | ![ImageWithSize](/hatrac/facebase/genesummaries/Irf6_oral_E13.5.jpg){width=100} | ![ImageWithSize](/hatrac/facebase/genesummaries/Irf6_oral_E14.5.jpg){width=100} | ![ImageWithSize](/hatrac/facebase/genesummaries/Irf6_oral_E15.5.jpg){width=100} | N: Nasal Pr: Proximal Di: Distal O: Oral ![Image](/hatrac/facebase/genesummaries/legend_blue_line.png) All epithelium #### Sources: - Immunofluorescence. Unpublished data from [Chai Lab, University of Southern California.](http://face.usc.edu/) ### Gene expression in the mandibular and maxillary arches _Irf6_ is expressed in the oral epithelium throughout development. | E10.5 | E12.5 | E14.5 | |-------|-------|-------| | ![ImageWithSize](/hatrac/facebase/genesummaries/irf6-10.5.jpg){width=280 height=214} | ![ImageWithSize](/hatrac/facebase/genesummaries/irf6-12.5.jpg){width=280 height=214} | ![ImageWithSize](/hatrac/facebase/genesummaries/irf6-14.5.jpg){width=280 height=214} | | ![Image](/hatrac/facebase/genesummaries/48a3ea.gif) Oral epithelium | ![Image](/hatrac/facebase/genesummaries/48a3ea.gif) Oral epithelium | ![Image](/hatrac/facebase/genesummaries/48a3ea.gif) Oral epithelium | #### Sources: - Knight AS, Schutte BC, Jiang R, Dixon MJ.Developmental expression analysis of the mouse and chick orthologues of IRF6: the gene mutated in Van der Woude syndrome. Dev Dyn. 2006 May;235(5):1441-7. - Unpublished data from [Chai's Lab, University of Southern California.](http://face.usc.edu/). ### Related Datasets - [All related FaceBase data for Irf6](/data/recordset/#1/isa:dataset/*::facets::N4IghgdgJiBcDaoDOB7ArgJwMYFM6JAEsIAjdafIpMEAGhCjABcwkcmB9Acxwhw8Ys2nQlA4AzANY4AniAC6AX1qh0TMmgoIqNeoNbtuvfjz4TpcpXpIAPDDnEL6WABYpCuJJQASAcQByAMKwAGwAjABMYbAKikpAA) ### External Links - [Irf6 interferon regulatory factor 6 [ Mus musculus ]](http://www.ncbi.nlm.nih.gov/gene/54139) - [IRF6 interferon regulatory factor 6 [ Homo sapiens ]](http://www.ncbi.nlm.nih.gov/gene/3664) - [interferon regulatory factor 6 genecard](http://www.genecards.org/cgi-bin/carddisp.pl?gene=IRF6&search=IRF6) - [IRF6 Wikipedia](http://en.wikipedia.org/wiki/IRF6)