cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.1285/i9788883051555p31
title: Study of n-photon emission processes in nanodiamond photocathodes

description: In this work we investigate on the characteristics of electron beams generated by three photocathodes (PC), one based on Cu sample and two on different nanodiamond (ND) layers. Specifically, the active layers of the ND-based PCs consisted of untreated and hydrogenated ND particles, 250 nm in size, sprayed on p-doped silicon substrates. We show photoemission measurements, carried out by a KrF nanosecond excimer laser (λ=248 nm; photon energy 5 eV) in a vacuum chamber at 10-6 mbar. We also make a study of the n-photon emission processes for all the PCs. The obtained results showed QE values of the ND-based photocathodes higher than that of the reference Cu one. In particular, the hydrogenated ND-based PC showed the highest QE thanks to the negative electron affinity of its surface.
description: In questo lavoro viene eseguito uno studio sulle proprietà di fotoemissione di tre fotocatodi (F), due basati su strati di nanodiamanti (ND) ed uno su rame. Nello specifico, gli strati attivi dei due PC con ND consistono di nanoparticelle di diamante tal quale ed idrogenate, della dimensione di 250 nm. Questi strati sono stati depositati su silicio drogato di tipo p, con la tecnica spray pulsata. Si presentano misure di fotoemissione, eseguite con un laser ad eccimeri KrF (λ=248 nm, t=25 ns) in una camera da vuoto (10-6 mbar) e si valuta il contributo di emissione multifotonica per tutti i catodi. I risultati ottenuti hanno mostrato valori di efficienza quantica più alta per i fotocatodi basati su ND; in particolare quelli idrogenati sono stati i più efficienti grazie all'affinità elettronica negativa della loro superficie.
DOI: 10.1285/i9788883051555p146
title: Modelli biofisici in silico per la predizione di inibitori enzimatici in modelli batterici

description: The development of new drugs is a hard and expensive goal for industry and scientists. The computational approach can drive this process reducing time and costs. This work show pipeline and software to models the interaction between a target enzyme and a small molecule (inhibitor). Usually, allosteric compounds can interact with the protein, inducing conformational rearrangement that affects the functionality of the enzyme. Here the 3D model of one enzyme, the isocitrate lyase (ICL), was modeled starting from a sequence of ICL of Streptomyces coelilolor and, using online tools, allosteric pockets were identified. Finally, the potential Inhibitors were screened using a docking method. ICL is an important factor of virulence and persistence in Mycobacterium tuberculosis, and one commercially available drug was identified: rapamycin, an mTOR inhibitor used in prevention of transplant rejection.
description: Gli inibitori enzimatici sono una classe di farmaci utilizzati per interferire a livello molecolare con la funzionalità di proteine "target". Spesso questi composti si comportano come modulatori allosterici, ovvero legano l'enzima in posizione diversa dal sito attivo inducendo dei cambiamenti conformazionali che disattivano funzionalmente l'enzima. Oggi, grazie a modelli computazionali, è possibile ottenere modelli in 3D di enzimi a struttura sconosciuta, identificando il sito attivo e le tasche allosteriche coinvolte in questo tipo di regolazione. Inoltre, grazie al docking è possibile stimare quanto un inibitore è affine ad una determinata tasca. Sfruttando quest'approccio abbiamo creato un modello biofisico di alcuni enzimi (isocitrato liasi, ICL) e identificato delle molecole potenzialmente utilizzabili come inibitori. In particolare, questo approccio è interessante poiché l'ICL è un fattore di virulenza e persistenza batterico. Fra gli inibitori identificati spicca il caso della rapamicina, molecola già disponibile in commercio utilizzata come immunosoppressore e come anti-neoplasico e che potenzialmente potrebbe essere utilizzata anche contro la tubercolosi.
DOI: 10.1285/i9788883051555p40
title: Dosimetrical evaluation of rotation errors in the patient set-up in lung SBRT treatments

description: Stereotactic body radiation therapy (SBRT) is a noninvasive, well-tolerated technique in the management of lung malignancies. SBRT requires a high degree of accuracy in target localization and treatment delivery to achieve tumor control while minimizing normal tissue toxicity. Through volumetric imaging, it is possible to obtain comprehensive assessment of patient positioning uncertainties before every treatment delivery. The purpose of this study was to quantify the magnitude of the rotational setup errors in lung SBRT using CBCT and to investigate the dosimetric impact of uncorrected rotational uncertainty. The dosimetric study was conducted on a thorax phantom. The retrospective analysis of CBCT set-up images shows that rotational errors detected in the patient's set-up are on average small in amplitude, although a certain variability index has been observed which can't be considered negligible in the evaluation of the dosimetric impact on the target coverage. The dosimetric study on phantom shows that the effect of uncorrected rotations on target coverage can't always be considered irrelevant and their clinical significance depends on the entity of rotation and target size. In conclusion, the presence of rotations in the positioning of the patient must be carefully investigated before every treatment delivery, especially for small targets size.
description: La stereotassi corporea (SBRT) è una terapia radioterapica non invasiva utilizzata nella cura dei tumori al polmone. SBRT richiede un alto grado di accuratezza nella localizzazione del tumore per ottenere un maggiore controllo della malattia minimizzando la tossicità ai tessuti sani. Mediante l'uso di immagini volumetriche, è possibile valutare gli errori di posizionamento del paziente prima del trattamento. Lo scopo di questo studio è quello di quantificare gli errori rotazionali di set up usando immagini CBCT di pazienti e valutare l'impatto dosimetrico di tali errori simulandoli su un fantoccio antropomorfo. L'analisi retrospettiva delle immagini di set up mostra che gli errori rotazionali rilevati sono in media piccoli in ampiezza, tuttavia l'indice di variabilità osservato può incidere sull'accuratezza della copertura dosimetrica del target. Lo studio dosimetrico sul fantoccio mostra che gli effetti di errori di rotazione dal punto di vista dosimetrico dipendono dalla entità di rotazione e dalle dimensioni del target. L'errore di rotazione dovrebbe essere valutato e corretto prima di ogni trattamento, soprattutto in presenza di lesioni di piccole dimensioni.
DOI: 10.25345/c5k698
title: MassIVE MSV000085165 - GNPS test test test test test test test
title: GNPS test test test test test test test test test test test test test test test test test
DOI: 10.1285/i9788883051555p157
title: Analysis of the Radish Seed Germination and Growth by Radiofrequency Stresses

description: In this work we report a study on the behavior of radish seed (Raphanus sativum L.) germination and growth under radiofrequency stresses. Groups of uniform seeds were irradiated at five duration time values of 60, 210, 375, 470 and 830 h at medium frequency of 1 Mhz, (MF/1), (MF/2), (MF/3), (MF/4) and (MF/5), respectively; at very high frequency of 100 Mhz, (VHF/1), (VHF/2) f(VHF/3), (VHF/4) and (VHF/5), respectively; at ultra high frequency of 900Mhz, (UHF/1), (UHF/2), (UHF/3), (UHF/4) and (UHF/5), respectively. The exhibited magnetic field for the three frequencies was of about 240 nT and the associate electric field inside the samples was less than 71 V/m, owing to the electric permittivity exposed sample. Another group of uniform radish seeds, irradiated by static magnetic (SM) field of 80 mT for the same time duration, was used as comparison, whereas untreated ones were used as control. The results showed that all physical stresses induced by magnetic fields did not have effect on seed germination as well as on cell elongation growth of the radish hypocotyls. On the contrary, a stimulating effect was observed on root growth.
DOI: 10.1285/i9788883051555p50
title: Effects of physical stresses on radish seed germination and growth

description: In this work we explore the consequences on variable magnetic fields applied to radish seeds (Raphanus sativum L.) on germination and seedling growth. Three, different alternate magnetic fields have been tested having a high intensity, 40 mT, at very low frequency, 0.2 Hz (B0.2), a low intensity, 577 µT, at low frequency, 370 kHz (B370), and a very low intensity, about 250 nT, at ultra high frequency, 900 MHz (RF900). These last generate electromagnetic waves which are nowadays very used for mobile communications. Groups of uniform radish seeds were exposed to alternate magnetic fields at three duration time values: i) 120 h (BO.2/1), 260 h (B0.2/2) and 360 h (B0.2/3) at high intensity and very low frequency, 0.2 Hz; ii) 120 h (B370/1), 260 h (B370/2), 360 h (B370/3) at low intensity and low frequency, 370 kHz; iii) 120 h (RF/1), 260 h (RF/2), 360 h (RF/3) at very low intensity and ultra high frequency, 900 MHz. Furthermore, another group of seeds was treated by laser beams of 248 nm wavelength whose magnetic field is coupled to an electric field. These two fields, by the Planck theory, origin the quantum energy, expresses by photons. Therefore, in the laser-matter interaction photons are absorbed dependent on laser shots. Again, we performed experiments at three duration time values that applied: 30 kshots (KrF/1), 80 kshots (KrF/2) and 135 kshots (KrF/3) at 40 mJcm2/ fluence. The magnetic field and electric field presented by the laser beam are approximatively 250 kVm/ and 850 µT, respectively. All treatments were performed at room temperature. Both untreated seeds and each group of seeds exposed to the physical stresses were transferred in Petri dishes and followed for their germination and seedling growth up to 96 h. The results showed that all physical stresses induced by alternate magnetic fields, radiofrequency and laser radiations did not have effect on seed germination as well as on cell elongation growth of the radish hypocotyls in comparison to control seeds. On the contrary, all physical stresses showed a significate stimulation on root growth.
DOI: 10.1285/i9788883051555p168
title: Indice Autori
DOI: 10.1285/i9788883051555p59
title: Performance of Delta4 Phantom+ using Flattening-Filter and Flattening Filter-Free beams

description: The goal of this study was to evaluate the performances of the new pre-treatment system Delta4 Phantom+ in terms of a stable and sensitive tool for achieving a reliable verification. Delta4+ was evaluated for verification with 6FFFMV beams using static beam arrangement. The accelerator output was monitored with the ionization chamber. The device was tested for dose-rate dependence, linearity and stability using its daily output correction. The response of Delta4+ was evaluated for energy 6FFFMV, measuring the gamma index of four Volumetric Modulated Arc Therapy (VMAT) plan. The response of Delta4+ as a function of accelerator dose rate is in agreement with the ionization chamber with a difference smaller than 0,1%. The output is constant for different MU. VMAT plan analysis show values within 98,3%-100% with a threshold of 3%-3mm, while with a threshold of 2%-2mm the values are within 93,5%-97,5%. Delta4+ is an accurate device. For all the measurements made, uncertainties below 1% were obtained.
description: Lo scopo di questo studio è stato quello di valutare la risposta in termini di stabilità e sensibilità del nuovo sistema pre-trattamento Delta4 Phantom+. La risposta del sistema è stato studiata utilizzando fasci di fotoni da 6MVsenza filtro di flattening (6FFFMV). L'output dell'acceleratore è stato monitorato con una camera a ionizzazione. La dipendenza dal dose rate, la linearità e la stabilità sono state verificate utilizzando il fattore di correzione giornaliera fornito dal sistema. La risposta è stata verificata su 4 piani di trattamento con tecnica VMAT. La risposta del Delta4+ al variare del dose rate è in accordo con quella della camera a ionizzazione con una scarto minore dello 0.1%. La risposta al variare delle UM è costante con una differenza entro lo 0.4%. L'analisi dei piani VMAT mostra valori di indice gamma per soglia 3%-3mm compresi tra 98.3%-100%, mentre per 2%-2mm i valori sono tra 93,5%-97,5%. Il Delta4+ risulta essere un sistema accurato in quanto l'incertezza ottenuta su tutte le misure non supera l'1%.
DOI: 10.1285/i9788883051555p172
title: Libri
DOI: 10.4119/unibi/2942042
title: Zebra finches bi-directionally selected for personality differ in repeatability of corticosterone and testosterone

description: Data to the publication "Zebra finches bi-directionally selected for personality differ in repeatability of corticosterone and testosterone" to appear in Hormones & Behavior
DOI: 10.1285/i9788883051555p67
title: Multi-probe analysis for the definition of chemical and physical properties of the medieval frescoes of Santa Maria di Cerrate

description: The complementary use of several diagnostic techniques allows a wide-ranging characterisation of a material and its chemical and physical properties, crossing information of its composition through qualitative and semi-quantitative analyses with the investigation of the crystalline components and the vibrational modes of its molecules. Moreover, studies of macro and micro-imaging can give a morphological description of the evaluated material, viewed both on surface and in cross section. A multi-analytical research carried out at the laboratories of the Center of Applied Physics, Dating and Diagnostics (CEDAD) of the University of Salento using Scanning Electron Microscopy (SEM-EDX), X-ray Diffraction (XRD), Raman Spectroscopy and Radiocarbon Dating by Accelerator Mass Spectrometry (AMS) permitted a deep and complete study on some samples of mortars, pigments, vegetal remains and degradation products from the frescos in the church of Santa Maria di Cerrate (Lecce), during the restoration work promoted by the FAI foundation (FondoAmbienteItaliano), giving a relevant contribution. In fact, in the field of conservation of Cultural Heritage, the physical-chemical characterization of the materials allows to gain fundamental information about both their degradation and the manufacturing techniques used by the artists, helping conservators in the actions of cleaning, consolidation and integration.
DOI: 10.1285/i9788883051555p72
title: XRD analysis of patinas on the monument dedicated to Saint Oronzo, Lecce

description: The monument dedicated to Saint Oronzo is placed in the homonymous square in the city centre of Lecce (Southern Italy). This monument consists of an internal wooden structure that is completely covered with copper sheets, lying on a concrete base about 1.5 meters high, which is placed on a Roman column about 29 meters high. The restoration of this manufact started in June 2018 and, first of all, non-destructive analyses are planned as proposed in the time-schedule. In this paper, we show the results of X-ray diffraction (XRD) analysis of the patinas both of the statue and of the column in order to evaluate their composition.
DOI: 10.1285/i9788883051555p78
title: Complex Acetabular Prosthetic Revisions. Comparison of modern materials in treatment strategies

description: The increasing number of total hip arthroplasty (THA) operations has inevitably led to an increase in the number of revisions for aseptic, septic or traumatic mobilization. The surgical treatment of these lesions is a demanding challenge for the surgeon: the primary objective is a stable osterexesis of the fracture that allows an early mobilization of the patient, therefore a careful evaluation of the materials to be implanted is also necessary. The aim of our study is to demonstrate the usefulness and limitations of new revision surgery technologies in cotiprosteal fractures. We enrolled 54 patients who underwent hip acetabular revision. The criteria chosen for the evaluation of outcomes: the visual analogue scale of pain in the traumatized hip (VAS); the subjective score of the Harris HIP Score; quality of life measured with The Short Form (12) Health Survey (SF-12); the average time of cup integration and complications. The evaluation endpoint was set at 24 months. The results, assessed with the aforementioned parameters, were on average good. Complications are the same as those described in the literature. The advantages of the new generation of acetabular components are: excellent integration and ductility of materials during revision of hip arthroplasty.
DOI: 10.21227/krvc-gw02
title: Technological Trends of Natural Language Processing Based Semantic Analysis: A Comparative Study of the US, the EU, and Korea Patents Data

description: The age of Artificial Intelligence (AI) is coming. Since Natural Language Processing (NLP) is a core AI technology for communication between humans and devices, it is vital to understand technological trends. Early research on NLP focused on syntactic processing such as information extraction and subject modeling but later developed into the semantic-oriented analysis. To analyze technological trends concerning NLP, especially semantic analysis, patent data that contains objective and extensive information is analyzed. The analysis procedures follow text mining to collect patent information, pre-processing, and analysis in keyword frequency, keyword network, and time series. The results reveal that there is a difference in the direction of technological development as the core keywords are at different frequencies and centrality among countries. Besides, from the time series analysis for five intervals over 20 years, twelve keywords of the rising / falling trend are observed in the US, seven in the EU, and five in Korea. The greater number of keywords infer that the US underwent further technological progress as compared to other countries. Moreover, the technical linkage of the US-EU is presumed to be sturdier than the US-Korea based on the keyword similarity over time. The analysis results of this study can be used as valuable references for future technical predictions related to NLP.
DOI: 10.21227/wqem-sj55
title: Technological Trends of Natural Language Processing Based Semantic Analysis: A Comparative Study of the US, the EU, and Korea Patents Data

description: The age of Artificial Intelligence (AI) is coming. Since Natural Language Processing (NLP) is a core AI technology for communication between humans and devices, it is vital to understand technological trends. Early research on NLP focused on syntactic processing such as information extraction and subject modeling but later developed into the semantic-oriented analysis. To analyze technological trends concerning NLP, especially semantic analysis, patent data that contains objective and extensive information is analyzed. The analysis procedures follow text mining to collect patent information, pre-processing, and analysis in keyword frequency, keyword network, and time series. The results reveal that there is a difference in the direction of technological development as the core keywords are at different frequencies and centrality among countries. Besides, from the time series analysis for five intervals over 20 years, twelve keywords of the rising / falling trend are observed in the US, seven in the EU, and five in Korea. The greater number of keywords infer that the US underwent further technological progress as compared to other countries. Moreover, the technical linkage of the US-EU is presumed to be sturdier than the US-Korea based on the keyword similarity over time. The analysis results of this study can be used as valuable references for future technical predictions related to NLP.
DOI: 10.1285/i9788883051555p84
title: Voluntary reporting of errors in radiotherapy. Errors collection in radiotherapy

description: A reporting worksheet was developed in 2001 to collect the errors discovered in the department. The worksheet comprised the following variables: body site, machine and energy, phase of RT procedure, description of incident, how discovered, date of incident, date of discovery, staff member involved in incident and staff member who discovered it (only qualification). The personnel was required reporting events explaining the importance of safeguarding patients and assuring that no disciplinary trial would be opened. Up to 2016 were collected 101 worksheets. 34 in breast treatments, 21 Head and Neck (H and N), 9 Chest, 19 Pelvis, 13 bone metastases (MTX), 5 brain. In 2001-2009 were collected 37 events, 24 Near Miss (NM), 13 Incident (I), 2 of them harmful. In 2009-2012 42 NM, no I, 2014-2016 22 events, 21 NM and 1 incident. In 2001-2009 majority of the errors was made in prescription phase (12/37), in 2009-2012 in dose-calculation phase and transfer phase (19/42). In 2014-2016 the events were balanced in all the phases. Although voluntary reporting of errors does not discover all the errors, it permits to improve the procedures and to increase a positive culture towards errors. Their distribution among sites of treatment, professionals and steps of the treatment pathways is significant different in the three periods considered. Collection and analysis of errors may improve patient's safety in radiation oncology.
DOI: 10.1285/i9788883051555p89
title: NOPAL: Natural Origin Protective for Artistic buildings in Lecce stone. Preliminary results.

description: The work presents the preliminary results of the experimentation of innovative coatings for the protection of artefacts in Lecce stone. Starting from the cladodium of the species Opuntia Ficus-Indica (NOPAL), plant extracts were obtained and their performance have been studied through aging tests and the use of optical and spectroscopic methods, in order to develop a new ecofriendly product, that meets the requirements of non-toxicity, biodegradability, and low cost, and able to efficiently preserve the built heritage made of Lecce stone.
description: Il lavoro presenta i risultati preliminari ottenuti dalla sperimentazione in laboratorio di innovativi protettivi green per la protezione dei materiali artistici in pietra leccese. A partire dalla specie Opuntia Ficus-Indica (NOPAL) sono stati ottenuti degli estratti vegetali e le loro performance sono state studiate attraverso test di invecchiamento e l'uso di metodologie ottiche e spettroscopiche, con il fine ultimo di formulare un nuovo prodotto ecofriendly che risponda ai requisiti di non tossicità, biodegradabilità, biocompatibilità, economicità.
DOI: 10.1285/i9788883051555p0
title: Frontespizio