cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.5943235
title: Supplementary Material for: Dermoscopy Improves the Diagnostic Accuracy of Melanomas Clinically Resembling Seborrheic Keratosis: Cross-Sectional Study of the Ability to Detect Seborrheic Keratosis-Like Melanomas by a Group of Dermatologists with Varying Degrees of Experience

description: <b><i>Background:</i></b> Malignant melanomas mimicking seborrheic keratosis (SK-like MMs) carry the risk of delayed diagnosis and inadequate treatment. The value of dermoscopy to improve the correct detection of these mimickers has not been previously studied. <b><i>Objective:</i></b> To evaluate the diagnostic accuracy of clinically SK-like MMs with and without dermoscopy. <b><i>Methods:</i></b> Clinical and dermoscopic images of histopathologically proven SK-like MMs (<i>n</i> = 134) intermingled with other melanomas and benign tumors were randomly presented to clinicians with different levels of experience, blinded to the diagnosis and goal of the study. Each participant classified each lesion as melanoma or benign tumor. The clinical and clinical-dermoscopic diagnostic accuracies were measured separately. <b><i>Results:</i></b> Overall, 54 participants with a mean clinical experience of 15.8 years (SD 11.8) evaluated 231 tumors. Almost 40% of SK-like melanomas were clinically misclassified as benign tumor. Dermoscopy improved diagnostic accuracy for all participants, independently of experience, from 60.9 to 68.1% (<i>p</i> &lt; 0.001), mostly due to a significant increase in the sensitivity (clinical 61.9% vs. dermoscopic 74.5%) (<i>p</i> &lt; 0.001). Dermoscopy did not significantly affect specificity among the experienced participants (≥6 years of experience) compared to clinical examination (61.1 vs. 59.6%, respectively); in contrast, dermoscopy was associated with a decrease in specificity compared to clinical diagnosis among novice participants (&lt; 6 years) (45.6 vs. 61.1%, respectively; <i>p</i> = 0.02). <b><i>Conclusion:</i></b> Melanomas can be clinically indistinguishable from SKs despite being evaluated by expert dermatologists. Dermoscopy, even in nonexpert hands, significantly improves their recognition.
DOI: 10.6084/m9.figshare.5943214
title: Supplementary Material for: A Prospective Observational Study Evaluating the Correlation of <b><i>c-MET</i></b> Expression and <b><i>EGFR</i></b> Gene Mutation with Response to Erlotinib as Second-Line Treatment for Patients with Advanced/Metastatic Non-Small-Cell Lung Cancer

description: <b><i>Objectives:</i></b> We aimed to evaluate the prevalence and predictive role of <i>c-MET</i> expression and <i>EGFR</i> mutation in the efficacy of erlotinib in non-small-cell lung cancer (NSCLC). <b><i>Methods:</i></b> We prospectively recruited 196 patients with stage IV or recurrent NSCLC treated with erlotinib after failure of first-line chemotherapy. Immunohistochemistry was used to evaluate <i>c-MET</i> overexpression, silver in situ hybridization (SISH) to assess gene copy number, and real-time polymerase chain reaction to detect <i>EGFR</i> mutations, respectively, in tumor tissue. <b><i>Results:</i></b> The major histologic type was adenocarcinoma (66.8%). <i>c-MET</i> was overexpressed in 55.8% (87/156) and dominant in females as well as non-squamous histology. Although <i>c-MET</i> gene amplification and high polysomy were observed in 2.0% (3/152) and 11.2% (17/152), they did not correlate with any characteristics. <i>EGFR</i> mutation was detected in 13.1% (20/153). The objective response rate of erlotinib was higher (61.1 vs. 3.7%, <i>p</i> &lt; 0.001) and the median progression-free survival (PFS) was longer (10.2 vs. 1.9 months, <i>p</i> &lt; 0.001) in EGFR-sensitizing mutations. However, <i>c-MET</i> positivity did not show a significant correlation with response to erlotinib or PFS. <b><i>Conclusion:</i></b> We reconfirmed <i>EGFR</i> mutation as a strong predictive marker of NSCLC. However, <i>c-MET</i> positivity was not associated with response or PFS, although <i>c-MET</i> overexpression correlated with some clinical characteristics.
DOI: 10.6084/m9.figshare.5943214.v1
title: Supplementary Material for: A Prospective Observational Study Evaluating the Correlation of <b><i>c-MET</i></b> Expression and <b><i>EGFR</i></b> Gene Mutation with Response to Erlotinib as Second-Line Treatment for Patients with Advanced/Metastatic Non-Small-Cell Lung Cancer

description: <b><i>Objectives:</i></b> We aimed to evaluate the prevalence and predictive role of <i>c-MET</i> expression and <i>EGFR</i> mutation in the efficacy of erlotinib in non-small-cell lung cancer (NSCLC). <b><i>Methods:</i></b> We prospectively recruited 196 patients with stage IV or recurrent NSCLC treated with erlotinib after failure of first-line chemotherapy. Immunohistochemistry was used to evaluate <i>c-MET</i> overexpression, silver in situ hybridization (SISH) to assess gene copy number, and real-time polymerase chain reaction to detect <i>EGFR</i> mutations, respectively, in tumor tissue. <b><i>Results:</i></b> The major histologic type was adenocarcinoma (66.8%). <i>c-MET</i> was overexpressed in 55.8% (87/156) and dominant in females as well as non-squamous histology. Although <i>c-MET</i> gene amplification and high polysomy were observed in 2.0% (3/152) and 11.2% (17/152), they did not correlate with any characteristics. <i>EGFR</i> mutation was detected in 13.1% (20/153). The objective response rate of erlotinib was higher (61.1 vs. 3.7%, <i>p</i> &lt; 0.001) and the median progression-free survival (PFS) was longer (10.2 vs. 1.9 months, <i>p</i> &lt; 0.001) in EGFR-sensitizing mutations. However, <i>c-MET</i> positivity did not show a significant correlation with response to erlotinib or PFS. <b><i>Conclusion:</i></b> We reconfirmed <i>EGFR</i> mutation as a strong predictive marker of NSCLC. However, <i>c-MET</i> positivity was not associated with response or PFS, although <i>c-MET</i> overexpression correlated with some clinical characteristics.
DOI: 10.6084/m9.figshare.5943199
title: Supplementary Material for: Hyperhidrosis – Sweating Sites Matter: Quality of Life in Primary Hyperhidrosis according to the Sweating Sites Measured by SF-36

description: <b><i>Background:</i></b> Primary hyperhidrosis has negative impacts on quality of life. The aim of this study was to investigate whether the impacts of primary hyperhidrosis on quality of life are different depending on the localisation of the sweating. <b><i>Method:</i></b> We compiled background data, Hyperhidrosis Disease Severity Scale (HDSS), and Short-Form Health Survey (SF-36) post hoc results from 2 previous studies. Cases who described only 1 site as their most problematic area of sweating were included (<i>n</i> = 160/188) while individuals with multifocal primary sites of hyperhidrosis were excluded (<i>n</i> = 28/188). <b><i>Results:</i></b> Individuals included were 11–62 years old with a mean age of 30.2 ± 10.4 years, and axillary hyperhidrosis (65.6%) was the most common type of hyperhidrosis. Comorbidities were more common when hyperhidrosis was reported in other than the axillary, palmar, and plantar regions. Excluding comorbidities showed the lowest SF-36 mental component summary scores for axillary (41.6 ± 11.6), palmar (40.0 ± 9.4), and plantar hyperhidrosis (41.1 ± 13.7). The HDSS showed the highest proportion of severe cases in axillary (60.6%) and palmar (51.5%) hyperhidrosis (<i>p</i> &lt; 0.01) while mild cases were more often observed in plantar (60%), facial (83.3%), and other sites (85.7%) in primary hyperhidrosis (<i>p</i> &lt; 0.01). <b><i>Conclusion:</i></b> Our results indicate that impairments in quality of life can be different depending on the manifestation of primary hyperhidrosis on the body. This can have an influence on how patients with hyperhidrosis could be prioritised in health care. Subgroup samples affected by facial hyperhidrosis and other sites of primary hyperhidrosis were however small, and more research is required to verify our findings.
DOI: 10.6084/m9.figshare.5943199.v1
title: Supplementary Material for: Hyperhidrosis – Sweating Sites Matter: Quality of Life in Primary Hyperhidrosis according to the Sweating Sites Measured by SF-36

description: <b><i>Background:</i></b> Primary hyperhidrosis has negative impacts on quality of life. The aim of this study was to investigate whether the impacts of primary hyperhidrosis on quality of life are different depending on the localisation of the sweating. <b><i>Method:</i></b> We compiled background data, Hyperhidrosis Disease Severity Scale (HDSS), and Short-Form Health Survey (SF-36) post hoc results from 2 previous studies. Cases who described only 1 site as their most problematic area of sweating were included (<i>n</i> = 160/188) while individuals with multifocal primary sites of hyperhidrosis were excluded (<i>n</i> = 28/188). <b><i>Results:</i></b> Individuals included were 11–62 years old with a mean age of 30.2 ± 10.4 years, and axillary hyperhidrosis (65.6%) was the most common type of hyperhidrosis. Comorbidities were more common when hyperhidrosis was reported in other than the axillary, palmar, and plantar regions. Excluding comorbidities showed the lowest SF-36 mental component summary scores for axillary (41.6 ± 11.6), palmar (40.0 ± 9.4), and plantar hyperhidrosis (41.1 ± 13.7). The HDSS showed the highest proportion of severe cases in axillary (60.6%) and palmar (51.5%) hyperhidrosis (<i>p</i> &lt; 0.01) while mild cases were more often observed in plantar (60%), facial (83.3%), and other sites (85.7%) in primary hyperhidrosis (<i>p</i> &lt; 0.01). <b><i>Conclusion:</i></b> Our results indicate that impairments in quality of life can be different depending on the manifestation of primary hyperhidrosis on the body. This can have an influence on how patients with hyperhidrosis could be prioritised in health care. Subgroup samples affected by facial hyperhidrosis and other sites of primary hyperhidrosis were however small, and more research is required to verify our findings.
DOI: 10.6084/m9.figshare.5943190
title: Potential of the <i>Moringa oleifera</i> saline extract for the treatment of dairy wastewater: application of the response surface methodology

description: In this work, the coagulation/flocculation/sedimentation treatment of dairy wastewater samples was investigated through serial factorial designs utilizing the saline extract obtained from <i>Moringa oleifera</i> (Moringa) as a coagulant. The sedimentation time (ST), pH, Moringa coagulant (MC) dose and concentration of CaCl<sub>2</sub> have been evaluated through the response surface methodology in order to obtain the ideal turbidity removal (TR) conditions. The empirical quadratic model, in conjunction with the desirability function, demonstrated that it is possible to obtain TRs of 98.35% using a coagulant dose, concentration of CaCl<sub>2</sub> and pH of 280 mg L<sup>−1</sup>, 0.8 mol L<sup>−1</sup> and 9, respectively. The saline extract from Moringa presented its best efficiency at an alkaline pH, which influenced the reduction of the ST to a value of 25 min. It was verified that the increase in the solubility of the proteins in the Moringa stimulated the reduction of the coagulant content in the reaction medium, and it is related to the use of calcium chloride as an extracting agent of these proteins. The MC proved to be an excellent alternative for the dairy wastewater treatment, compared to the traditional coagulants.
DOI: 10.6084/m9.figshare.5943190.v1
title: Potential of the <i>Moringa oleifera</i> saline extract for the treatment of dairy wastewater: application of the response surface methodology

description: In this work, the coagulation/flocculation/sedimentation treatment of dairy wastewater samples was investigated through serial factorial designs utilizing the saline extract obtained from <i>Moringa oleifera</i> (Moringa) as a coagulant. The sedimentation time (ST), pH, Moringa coagulant (MC) dose and concentration of CaCl<sub>2</sub> have been evaluated through the response surface methodology in order to obtain the ideal turbidity removal (TR) conditions. The empirical quadratic model, in conjunction with the desirability function, demonstrated that it is possible to obtain TRs of 98.35% using a coagulant dose, concentration of CaCl<sub>2</sub> and pH of 280 mg L<sup>−1</sup>, 0.8 mol L<sup>−1</sup> and 9, respectively. The saline extract from Moringa presented its best efficiency at an alkaline pH, which influenced the reduction of the ST to a value of 25 min. It was verified that the increase in the solubility of the proteins in the Moringa stimulated the reduction of the coagulant content in the reaction medium, and it is related to the use of calcium chloride as an extracting agent of these proteins. The MC proved to be an excellent alternative for the dairy wastewater treatment, compared to the traditional coagulants.
DOI: 10.6084/m9.figshare.5943181
title: Charity Open Access Fund (COAF) expenditure report 2013-14

description: Charity Open Access Fund (COAF) expenditure report 2013-14 for the London School of Hygiene & Tropical Medicine
DOI: 10.6084/m9.figshare.5943181.v1
title: Charity Open Access Fund (COAF) expenditure report 2013-14

description: Charity Open Access Fund (COAF) expenditure report 2013-14 for the London School of Hygiene & Tropical Medicine
DOI: 10.6084/m9.figshare.5943178
title: Charity Open Access Fund (COAF) expenditure report 2014-15

description: Charity Open Access Fund (COAF) expenditure report 2014-15 for the London School of Hygiene & Tropical Medicine
DOI: 10.6084/m9.figshare.5943178.v1
title: Charity Open Access Fund (COAF) expenditure report 2014-15

description: Charity Open Access Fund (COAF) expenditure report 2014-15 for the London School of Hygiene & Tropical Medicine
DOI: 10.6084/m9.figshare.5943169
title: Charity Open Access Fund (COAF) expenditure report 2016-17

description: Charity Open Access Fund (COAF) expenditure report 2016-17 for the London School of Hygiene & Tropical Medicine.
DOI: 10.6084/m9.figshare.5943169.v1
title: Charity Open Access Fund (COAF) expenditure report 2016-17

description: Charity Open Access Fund (COAF) expenditure report 2016-17 for the London School of Hygiene & Tropical Medicine.
DOI: 10.6084/m9.figshare.5943136
title: Data Sangüesa-Barreda et al. 2018_JEcol.xlsx

description: All data used in this publication are included in this file. Sheets are: 1) Mistletoe ocurrence data, 2) <i>Pinus sylvestris</i> ocurrence data, 3) <i>Pinus halepensis</i> ocurrence data, 4) Mistletoe cold tolerance, 5) d13C for mistletoe and tree hosts in 2012 and 2013, 6) mistletoe germination and establishment. The description for each variable is included in the data file.<br><br>For further details, we refer to our publication: Sangüesa-Barreda et al. (2018). Delineating limits: confronting predicted climatic suitability to field performance in mistletoe populations, accepted for publication in Journal of Ecology.
DOI: 10.6084/m9.figshare.5943136.v1
title: Data Sangüesa-Barreda et al. 2018_JEcol.xlsx

description: All data used in this publication are included in this file. Sheets are: 1) Mistletoe ocurrence data, 2) <i>Pinus sylvestris</i> ocurrence data, 3) <i>Pinus halepensis</i> ocurrence data, 4) Mistletoe cold tolerance, 5) d13C for mistletoe and tree hosts in 2012 and 2013, 6) mistletoe germination and establishment. The description for each variable is included in the data file.<br><br>For further details, we refer to our publication: Sangüesa-Barreda et al. (2018). Delineating limits: confronting predicted climatic suitability to field performance in mistletoe populations, accepted for publication in Journal of Ecology.
DOI: 10.6084/m9.figshare.5943115
title: Subject 7_c3d

description: c3d files of Subject 7
DOI: 10.6084/m9.figshare.5943115.v1
title: Subject 7_c3d

description: c3d files of Subject 7
DOI: 10.6084/m9.figshare.5943112
title: Subject 6_c3d

description: c3d files of Subject 6
DOI: 10.6084/m9.figshare.5943112.v1
title: Subject 6_c3d

description: c3d files of Subject 6
DOI: 10.6084/m9.figshare.5943109
title: Subject 5_c3d

description: c3d files of Subject 5
DOI: 10.6084/m9.figshare.5943109.v1
title: Subject 5_c3d

description: c3d files of Subject 5
DOI: 10.6084/m9.figshare.5943106
title: Subject 3_c3d

description: c3d files of Subject 3
DOI: 10.6084/m9.figshare.5943106.v1
title: Subject 3_c3d

description: c3d files of Subject 3
DOI: 10.6084/m9.figshare.5943103
title: Subject 1_c3d

description: c3d files of Subject 1
DOI: 10.6084/m9.figshare.5943100
title: Subject 4_c3d

description: c3d files of Subject 4
DOI: 10.6084/m9.figshare.5943100.v1
title: Subject 4_c3d

description: c3d files of Subject 4
DOI: 10.6084/m9.figshare.5943097
title: Subject 2_c3d

description: c3d files of Subject 2
DOI: 10.6084/m9.figshare.5943097.v1
title: Subject 2_c3d

description: c3d files of Subject 2
DOI: 10.6084/m9.figshare.5942947
title: STRESS AND AUTONOMIC RESPONSE TO SLEEP DEPRIVATION IN MEDICAL RESIDENTS

description: El objetivo de este estudio fue evaluar el estrés producido por las guardias de 24 h en médicos residentes usando un enfoque multidimensional. Participaron dos grupos de médicos residentes que fueron seleccionados según el turno de trabajo: un grupo con privación de sueño (<i>n </i>= 42) que participó en una guardia activa de 24 h y otro grupo de contraste (<i>n </i>= 18) que participó en una jornada laboral normal sin privación de sueño. Todos completaron pre-post test durante un ciclo de 24 h realizadas las dos veces a las 8 h a.m. Las medidas incluyeron HRV, cortisol, rendimiento cognitivo y estado de ánimo transitorio. Los resultados mostraron que el efecto de la interacción grupo x fase fue significativa para todas las variables analizadas, indicando que los médicos en turno de guardia mostraban un deterioro significativo en todos los indicadores fisiológicos, de rendimiento y estado de ánimo en comparación con los participantes del grupo sin guardia. Estos resultados sugieren que es necesario revisar los sistemas de guardias médicas para reducir la carga de estrés que incide directamente en las condiciones de trabajo.
DOI: 10.6084/m9.figshare.5942947.v2
title: STRESS AND AUTONOMIC RESPONSE TO SLEEP DEPRIVATION IN MEDICAL RESIDENTS

description: El objetivo de este estudio fue evaluar el estrés producido por las guardias de 24 h en médicos residentes usando un enfoque multidimensional. Participaron dos grupos de médicos residentes que fueron seleccionados según el turno de trabajo: un grupo con privación de sueño (<i>n </i>= 42) que participó en una guardia activa de 24 h y otro grupo de contraste (<i>n </i>= 18) que participó en una jornada laboral normal sin privación de sueño. Todos completaron pre-post test durante un ciclo de 24 h realizadas las dos veces a las 8 h a.m. Las medidas incluyeron HRV, cortisol, rendimiento cognitivo y estado de ánimo transitorio. Los resultados mostraron que el efecto de la interacción grupo x fase fue significativa para todas las variables analizadas, indicando que los médicos en turno de guardia mostraban un deterioro significativo en todos los indicadores fisiológicos, de rendimiento y estado de ánimo en comparación con los participantes del grupo sin guardia. Estos resultados sugieren que es necesario revisar los sistemas de guardias médicas para reducir la carga de estrés que incide directamente en las condiciones de trabajo.
DOI: 10.6084/m9.figshare.5942947.v1
title: STRESS AND AUTONOMIC RESPONSE TO SLEEP DEPRIVATION IN MEDICAL RESIDENTS

description: El objetivo de este estudio fue evaluar el estrés producido por las guardias de 24 h en médicos residentes usando un enfoque multidimensional. Participaron dos grupos de médicos residentes que fueron seleccionados según el turno de trabajo: un grupo con privación de sueño (<i>n </i>= 42) que participó en una guardia activa de 24 h y otro grupo de contraste (<i>n </i>= 18) que participó en una jornada laboral normal sin privación de sueño. Todos completaron pre-post test durante un ciclo de 24 h realizadas las dos veces a las 8 h a.m. Las medidas incluyeron HRV, cortisol, rendimiento cognitivo y estado de ánimo transitorio. Los resultados mostraron que el efecto de la interacción grupo x fase fue significativa para todas las variables analizadas, indicando que los médicos en turno de guardia mostraban un deterioro significativo en todos los indicadores fisiológicos, de rendimiento y estado de ánimo en comparación con los participantes del grupo sin guardia. Estos resultados sugieren que es necesario revisar los sistemas de guardias médicas para reducir la carga de estrés que incide directamente en las condiciones de trabajo.
DOI: 10.6084/m9.figshare.5942941
title: Screening of broad spectrum natural pesticides against conserved target arginine kinase in cotton pests by molecular modeling

description: Cotton is an economically important crop and its production is challenged by the diversity of pests and related insecticide resistance. Identification of the conserved target across the cotton pest will help to design broad spectrum insecticide. In this study, we have identified conserved sequences by Expressed Sequence Tag profiling from three cotton pests namely <i>Aphis gossypii</i>, <i>Helicoverpa armigera,</i> and <i>Spodoptera exigua.</i> One target protein arginine kinase having a key role in insect physiology and energy metabolism was studied further using homology modeling, virtual screening, molecular docking, and molecular dynamics simulation to identify potential biopesticide compounds from the Zinc natural database. We have identified four compounds having excellent inhibitor potential against the identified broad spectrum target which are highly specific to invertebrates.
DOI: 10.6084/m9.figshare.5942941.v2
title: Screening of broad spectrum natural pesticides against conserved target arginine kinase in cotton pests by molecular modeling

description: Cotton is an economically important crop and its production is challenged by the diversity of pests and related insecticide resistance. Identification of the conserved target across the cotton pest will help to design broad spectrum insecticide. In this study, we have identified conserved sequences by Expressed Sequence Tag profiling from three cotton pests namely <i>Aphis gossypii</i>, <i>Helicoverpa armigera,</i> and <i>Spodoptera exigua.</i> One target protein arginine kinase having a key role in insect physiology and energy metabolism was studied further using homology modeling, virtual screening, molecular docking, and molecular dynamics simulation to identify potential biopesticide compounds from the Zinc natural database. We have identified four compounds having excellent inhibitor potential against the identified broad spectrum target which are highly specific to invertebrates.