cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.48597/7m33-b42j
title: Measurement of Zinc at Terningvatn

description: Measurement of Zinc at Terningvatn
DOI: 10.48597/7nnd-rdct
title: Measurement of Heavy metals at Illmitz

description: Measurement of Heavy metals at Illmitz
DOI: 10.48597/82gf-z343
title: Measurement of POPs (persistent organic pollutants) at Råö

description: Measurement of POPs (persistent organic pollutants) at Råö
DOI: 10.48597/8dw5-cmgy
title: Measurement of Inorganics in precipitation at Råö

description: Measurement of Inorganics in precipitation at Råö
DOI: 10.48597/92t8-g67m
title: Measurement of Arsenic at Lista

description: Measurement of Arsenic at Lista
DOI: 10.48597/9ej3-zh7m
title: Measurement of Precipitation_amount at Noatun

description: Measurement of Precipitation_amount at Noatun
DOI: 10.48597/9ry8-48gz
title: Measurement of Heavy metals at Lista

description: Measurement of Heavy metals at Lista
DOI: 10.48597/9u2q-pgd3
title: Measurement of POPs (persistent organic pollutants) at Pallas (Matorova)

description: Measurement of POPs (persistent organic pollutants) at Pallas (Matorova)
DOI: 10.48597/a9fv-82rt
title: Measurement of Heavy metals at Illmitz

description: Measurement of Heavy metals at Illmitz
DOI: 10.48597/an49-qcfx
title: Measurement of Beta_HCH at Zeppelin mountain (Ny-Ålesund)

description: Measurement of Beta_HCH at Zeppelin mountain (Ny-Ålesund)
DOI: 10.48597/apg6-3uhz
title: Measurement of Heavy metals at Terningvatn

description: Measurement of Heavy metals at Terningvatn
DOI: 10.48597/apnh-r287
title: Measurement of Heavy metals at Illmitz

description: Measurement of Heavy metals at Illmitz
DOI: 10.48597/bbed-uxqu
title: Measurement of Inorganics in air and particle phase at Ispra

description: Measurement of Inorganics in air and particle phase at Ispra
DOI: 10.48597/bv4y-ddy3
title: Measurement of POPs (persistent organic pollutants) at Aspvreten

description: Measurement of POPs (persistent organic pollutants) at Aspvreten
DOI: 10.48597/cjne-p8nh
title: Measurement of Sulphur_dioxide at Yarner Wood

description: Measurement of Sulphur_dioxide at Yarner Wood
DOI: 10.48597/dbyp-cnaj
title: Measurement of Precipitation_amount at Åmotsdalen

description: Measurement of Precipitation_amount at Åmotsdalen
DOI: 10.48597/dc9q-wvyx
title: Measurement of HCB at Pallas (Matorova)

description: Measurement of HCB at Pallas (Matorova)
DOI: 10.48597/dpam-yvyq
title: Measurement of Arsenic at Lista

description: Measurement of Arsenic at Lista
DOI: 10.48597/ebz3-86zw
title: Measurement of Heavy metals at Tjeldbergodden

description: Measurement of Heavy metals at Tjeldbergodden
DOI: 10.48597/epkj-3m7d
title: Measurement of Heavy metals at Tangen

description: Measurement of Heavy metals at Tangen
DOI: 10.48597/et7w-7d8x
title: Measurement of POPs (persistent organic pollutants) at Råö

description: Measurement of POPs (persistent organic pollutants) at Råö
DOI: 10.48597/f6d6-ng2j
title: Measurement of Sulphur_dioxide at Strath Vaich Dam

description: Measurement of Sulphur_dioxide at Strath Vaich Dam
DOI: 10.48597/fvbd-tqvy
title: Measurement of POPs (persistent organic pollutants) at Pallas (Matorova)

description: Measurement of POPs (persistent organic pollutants) at Pallas (Matorova)
DOI: 10.48597/fxyv-qv7y
title: Measurement of Heavy metals at Frihetsli

description: Measurement of Heavy metals at Frihetsli
DOI: 10.48597/g4mw-amgb
title: Measurement of Cobalt at Lista

description: Measurement of Cobalt at Lista
DOI: 10.48597/hmaa-jyzk
title: Measurement of Lead at Vorhegg

description: Measurement of Lead at Vorhegg
DOI: 10.48597/ja26-324t
title: Measurement of Inorganics in air and particle phase at Ispra

description: Measurement of Inorganics in air and particle phase at Ispra
DOI: 10.48597/jagp-4y6q
title: Measurement of Manganese at Lista

description: Measurement of Manganese at Lista
DOI: 10.48597/jneh-2e8k
title: Measurement of Sulphur_dioxide at Eskdalemuir

description: Measurement of Sulphur_dioxide at Eskdalemuir
DOI: 10.48597/jpzr-bnk9
title: Measurement of Sulphate_total at Ispra

description: Measurement of Sulphate_total at Ispra
DOI: 10.26179/2d4g-k720
title: Aurora Australis Voyage 2 2001-02 Underway Data
DOI: 10.48597/jthv-jqu8
title: Measurement of Precipitation_amount at Lista

description: Measurement of Precipitation_amount at Lista
DOI: 10.48597/khst-4fxb
title: Measurement of Sulphur_dioxide at High Muffles

description: Measurement of Sulphur_dioxide at High Muffles
DOI: 10.48597/kkw6-3g6z
title: Measurement of POPs (persistent organic pollutants) at Råö

description: Measurement of POPs (persistent organic pollutants) at Råö
DOI: 10.48597/ky9z-qa86
title: Measurement of Sulphur_dioxide at Lough Navar

description: Measurement of Sulphur_dioxide at Lough Navar
DOI: 10.48597/m7jz-q6n7
title: Measurement of Heavy metals at Frihetsli

description: Measurement of Heavy metals at Frihetsli
DOI: 10.48597/mevw-upa8
title: Measurement of Heavy metals at Lista

description: Measurement of Heavy metals at Lista
DOI: 10.48597/mgzq-6e3a
title: Measurement of PCBs (polychlorinated biphenyls, 7) at Kosetice (NOAK)

description: Measurement of PCBs (polychlorinated biphenyls, 7) at Kosetice (NOAK)
DOI: 10.48597/mna2-8s7a
title: Measurement of Heavy metals at Åmotsdalen

description: Measurement of Heavy metals at Åmotsdalen
DOI: 10.48597/nhtw-zyck
title: Measurement of Elemental_carbon and inorganics in air and particle phase at Ispra

description: Measurement of Elemental_carbon and inorganics in air and particle phase at Ispra
DOI: 10.48597/njft-scte
title: Measurement of Precipitation_amount at Valdalen

description: Measurement of Precipitation_amount at Valdalen
DOI: 10.48597/numg-jq9s
title: Measurement of Heavy metals at Vorhegg

description: Measurement of Heavy metals at Vorhegg
DOI: 10.48597/nwjh-svt9
title: Measurement of HCB at Pallas (Matorova)

description: Measurement of HCB at Pallas (Matorova)
DOI: 10.48597/ph42-g596
title: Measurement of Inorganics in precipitation at Øverbygd

description: Measurement of Inorganics in precipitation at Øverbygd
DOI: 10.48597/q795-s3tb
title: Measurement of PCBs (polychlorinated biphenyls, 7) at Pallas (Matorova)

description: Measurement of PCBs (polychlorinated biphenyls, 7) at Pallas (Matorova)
DOI: 10.48597/qqss-pqbp
title: Measurement of Lead at St. Koloman

description: Measurement of Lead at St. Koloman
DOI: 10.48597/qtpe-y9aq
title: Measurement of Elemental_carbon and inorganics in air and particle phase at Ispra

description: Measurement of Elemental_carbon and inorganics in air and particle phase at Ispra
DOI: 10.48597/r6aw-hmqw
title: Measurement of Zinc at Lista

description: Measurement of Zinc at Lista
DOI: 10.48597/rbfa-7ght
title: Measurement of Precipitation_amount at Tjeldbergodden

description: Measurement of Precipitation_amount at Tjeldbergodden
DOI: 10.48597/s96f-ucn8
title: Measurement of Heavy metals at Åmotsdalen

description: Measurement of Heavy metals at Åmotsdalen
DOI: 10.48597/sq9x-xx6g
title: Measurement of Heavy metals at Lista

description: Measurement of Heavy metals at Lista
DOI: 10.48597/ss5x-x7bg
title: Measurement of Heavy metals at Terningvatn

description: Measurement of Heavy metals at Terningvatn
DOI: 10.48597/t22b-q6yp
title: Measurement of Precipitation_amount at Solem

description: Measurement of Precipitation_amount at Solem
DOI: 10.48597/t6rr-ka9k
title: Measurement of Precipitation_amount at Vårli

description: Measurement of Precipitation_amount at Vårli
DOI: 10.48597/tnce-5t2j
title: Measurement of POPs (persistent organic pollutants) at Aspvreten

description: Measurement of POPs (persistent organic pollutants) at Aspvreten
DOI: 10.48597/tqxe-r4a3
title: Measurement of Heavy metals at Lista

description: Measurement of Heavy metals at Lista
DOI: 10.48597/tzut-2j6h
title: Measurement of Heavy metals at Illmitz

description: Measurement of Heavy metals at Illmitz
DOI: 10.48597/u9r6-8abv
title: Measurement of Heavy metals at Lista

description: Measurement of Heavy metals at Lista
DOI: 10.48597/uaby-5etr
title: Measurement of Vanadium at Lista

description: Measurement of Vanadium at Lista
DOI: 10.48597/ucjt-jkyr
title: Measurement of POPs (persistent organic pollutants) at Aspvreten

description: Measurement of POPs (persistent organic pollutants) at Aspvreten
DOI: 10.48597/ucv8-w327
title: Measurement of POPs (persistent organic pollutants) at Birkenes

description: Measurement of POPs (persistent organic pollutants) at Birkenes
DOI: 10.48597/udbd-mgy5
title: Measurement of Heavy metals at Illmitz

description: Measurement of Heavy metals at Illmitz
DOI: 10.15151/esrf-es-1552828899
title: Structural Biology at EMBL Grenoble, IBS-CIBB and IAB

description: This proposal clusters crystallography and bioSAXS projects at the EMBL Grenoble, IBS-CIBB and IAB. It combines groups working on different topics with a major focus on cell signaling proteins, drug discovery, long non-coding RNAs, nucleic acid-protein complexes, and host-pathogen interactions. The proposers have long-standing experience in the use, as well as the development of beam lines for macromolecular crystallography and biological small angle X-ray scattering and have participated in successive BAG applications over the years, mostly at the ESRF but also at other synchrotrons (i.e. Soleil, Petra III, and Diamond). As Stephen Cusack (former head of EMBL Grenoble) will be retiring at the end of 2023 we propose to change the BAG responsible to Andrew McCarthy for this application round.
DOI: 10.26179/4smk-vr54
title: Aurora Australis Voyage 3 2001-2002 Underway Data
DOI: 10.26179/7he8-h378
title: Polar Bird Voyage 4 2001-2002 Underway Data
DOI: 10.48597/ufnm-gp7z
title: Measurement of Zinc at Vårli

description: Measurement of Zinc at Vårli
DOI: 10.48597/ve2f-e597
title: Measurement of Heavy metals at Terningvatn

description: Measurement of Heavy metals at Terningvatn
DOI: 10.48597/vhyk-4evy
title: Measurement of PCB_180 at Kosetice (NOAK)

description: Measurement of PCB_180 at Kosetice (NOAK)
DOI: 10.48597/vvat-xg7d
title: Measurement of Heavy metals at Vårli

description: Measurement of Heavy metals at Vårli
DOI: 10.48597/wuvk-fxnj
title: Measurement of Sulphur_dioxide at Yarner Wood

description: Measurement of Sulphur_dioxide at Yarner Wood
DOI: 10.48597/wx9t-hnua
title: Measurement of Inorganics in air and particle phase at Ispra

description: Measurement of Inorganics in air and particle phase at Ispra
DOI: 10.48597/x7dq-symx
title: Measurement of Precipitation_amount at Hurdal

description: Measurement of Precipitation_amount at Hurdal
DOI: 10.48597/xry9-c7s8
title: Measurement of Heavy metals at Tjeldbergodden

description: Measurement of Heavy metals at Tjeldbergodden
DOI: 10.48597/y288-q9kn
title: Measurement of Heavy metals at Vårli

description: Measurement of Heavy metals at Vårli
DOI: 10.48597/y2xm-uc9m
title: Measurement of Zinc at Tjeldbergodden

description: Measurement of Zinc at Tjeldbergodden
DOI: 10.48597/y5an-h23v
title: Measurement of Precipitation_amount at Osen

description: Measurement of Precipitation_amount at Osen
DOI: 10.48597/y6aa-azgz
title: Measurement of Inorganics in air and particle phase at Ispra

description: Measurement of Inorganics in air and particle phase at Ispra
DOI: 10.48597/y7aw-3qs5
title: Measurement of POPs (persistent organic pollutants) at Aspvreten

description: Measurement of POPs (persistent organic pollutants) at Aspvreten
DOI: 10.48597/zeue-pvnw
title: Measurement of Inorganics in air and particle phase at Hurdal

description: Measurement of Inorganics in air and particle phase at Hurdal
DOI: 10.48597/2bza-gd37
title: Measurement of Pm25_mass at Washington D.C.

description: Measurement of Pm25_mass at Washington D.C.
DOI: 10.48597/2k9f-nwp2
title: Measurement of Pm25_mass at St. Marks

description: Measurement of Pm25_mass at St. Marks
DOI: 10.48597/2yns-frhq
title: Measurement of Pm25_mass at Weminuche Wilderness

description: Measurement of Pm25_mass at Weminuche Wilderness
DOI: 10.48597/3dk5-tyyg
title: Measurement of Pm10_mass at Weminuche Wilderness

description: Measurement of Pm10_mass at Weminuche Wilderness
DOI: 10.48597/443q-xxqn
title: Measurement of Pm10_mass at Washington D.C.

description: Measurement of Pm10_mass at Washington D.C.
DOI: 10.48597/46zy-va3w
title: Measurement of Pm10_mass at Washington D.C.

description: Measurement of Pm10_mass at Washington D.C.
DOI: 10.48597/4cgj-dedx
title: Measurement of Pm25_mass at St. Marks

description: Measurement of Pm25_mass at St. Marks
DOI: 10.48597/4suc-uctn
title: Measurement of Pm10_mass at Weminuche Wilderness

description: Measurement of Pm10_mass at Weminuche Wilderness
DOI: 10.48597/5bjv-bw96
title: Measurement of Pm25_mass at Washington D.C.

description: Measurement of Pm25_mass at Washington D.C.
DOI: 10.48597/5t42-gvn4
title: Measurement of Pm25_mass at Washington D.C.

description: Measurement of Pm25_mass at Washington D.C.
DOI: 10.48597/5x5y-qmx3
title: Measurement of Pm25_mass at Weminuche Wilderness

description: Measurement of Pm25_mass at Weminuche Wilderness
DOI: 10.48597/6net-fgs8
title: Measurement of Pm10_mass at Washington D.C.

description: Measurement of Pm10_mass at Washington D.C.
DOI: 10.48597/6snt-xrzb
title: Measurement of Pm25_mass at Weminuche Wilderness

description: Measurement of Pm25_mass at Weminuche Wilderness
DOI: 10.48597/6zdg-xbh2
title: Measurement of Pm10_mass at Washington D.C.

description: Measurement of Pm10_mass at Washington D.C.
DOI: 10.48597/7pzy-p5hb
title: Measurement of Pm25_mass at Washington D.C.

description: Measurement of Pm25_mass at Washington D.C.
DOI: 10.48597/7qet-2ded
title: Measurement of Pm10_mass at Washington D.C.

description: Measurement of Pm10_mass at Washington D.C.
DOI: 10.48597/7wde-4xsu
title: Measurement of Pm10_mass at Washington D.C.

description: Measurement of Pm10_mass at Washington D.C.
DOI: 10.48597/7x3y-qetc
title: Measurement of Pm25_mass at Washington D.C.

description: Measurement of Pm25_mass at Washington D.C.
DOI: 10.48597/7z3t-sfbr
title: Measurement of Pm25_mass at Washington D.C.

description: Measurement of Pm25_mass at Washington D.C.
DOI: 10.48597/8p7f-6jpw
title: Measurement of Pm25_mass at St. Marks

description: Measurement of Pm25_mass at St. Marks
DOI: 10.48597/8t2s-wgwv
title: Measurement of Pm10_mass at St. Marks

description: Measurement of Pm10_mass at St. Marks
DOI: 10.48597/97a5-ccdx
title: Measurement of Pm10_mass at Washington D.C.

description: Measurement of Pm10_mass at Washington D.C.
DOI: 10.48597/9gez-j63u
title: Measurement of Pm10_mass at Washington D.C.

description: Measurement of Pm10_mass at Washington D.C.
DOI: 10.48597/9hhu-ta9d
title: Measurement of Pm25_mass at Weminuche Wilderness

description: Measurement of Pm25_mass at Weminuche Wilderness
DOI: 10.48597/9hn8-hfzm
title: Measurement of Pm25_mass at Washington D.C.

description: Measurement of Pm25_mass at Washington D.C.
DOI: 10.48597/9q94-wwuz
title: Measurement of Pm25_mass at St. Marks

description: Measurement of Pm25_mass at St. Marks
DOI: 10.48597/9sbj-php3
title: Measurement of Pm25_mass at St. Marks

description: Measurement of Pm25_mass at St. Marks
DOI: 10.48597/ackf-jmgs
title: Measurement of Pm25_mass at Weminuche Wilderness

description: Measurement of Pm25_mass at Weminuche Wilderness
DOI: 10.48597/aew5-vksu
title: Measurement of Pm25_mass at Washington D.C.

description: Measurement of Pm25_mass at Washington D.C.
DOI: 10.48597/bkrt-3udt
title: Measurement of Pm25_mass at Washington D.C.

description: Measurement of Pm25_mass at Washington D.C.
DOI: 10.48597/c2kc-48r8
title: Measurement of Pm10_mass at Washington D.C.

description: Measurement of Pm10_mass at Washington D.C.
DOI: 10.48597/d7ab-ed5j
title: Measurement of Pm25_mass at Washington D.C.

description: Measurement of Pm25_mass at Washington D.C.
DOI: 10.48597/da4q-2k3x
title: Measurement of Pm10_mass at Weminuche Wilderness

description: Measurement of Pm10_mass at Weminuche Wilderness
DOI: 10.48597/e46e-urxr
title: Measurement of Pm10_mass at Weminuche Wilderness

description: Measurement of Pm10_mass at Weminuche Wilderness
DOI: 10.48597/esh3-9bw7
title: Measurement of Pm10_mass at Washington D.C.

description: Measurement of Pm10_mass at Washington D.C.
DOI: 10.48597/eu6s-xjzm
title: Measurement of Pm10_mass at Washington D.C.

description: Measurement of Pm10_mass at Washington D.C.
DOI: 10.48597/ezzv-b2ac
title: Measurement of Pm10_mass at Washington D.C.

description: Measurement of Pm10_mass at Washington D.C.
DOI: 10.48597/f3kv-gvh3
title: Measurement of Pm10_mass at Washington D.C.

description: Measurement of Pm10_mass at Washington D.C.
DOI: 10.48597/f49f-85ue
title: Measurement of Pm10_mass at Washington D.C.

description: Measurement of Pm10_mass at Washington D.C.
DOI: 10.48597/fjvr-qxu6
title: Measurement of Pm25_mass at Washington D.C.

description: Measurement of Pm25_mass at Washington D.C.
DOI: 10.48597/ft9x-rjmj
title: Measurement of Pm25_mass at Washington D.C.

description: Measurement of Pm25_mass at Washington D.C.
DOI: 10.48597/g2n3-e6tr
title: Measurement of Pm10_mass at Weminuche Wilderness

description: Measurement of Pm10_mass at Weminuche Wilderness
DOI: 10.48597/g4gw-4546
title: Measurement of Pm10_mass at Weminuche Wilderness

description: Measurement of Pm10_mass at Weminuche Wilderness
DOI: 10.48597/hcz2-4ddx
title: Measurement of Pm10_mass at Weminuche Wilderness

description: Measurement of Pm10_mass at Weminuche Wilderness
DOI: 10.48597/hpvz-twm6
title: Measurement of Pm10_mass at St. Marks

description: Measurement of Pm10_mass at St. Marks
DOI: 10.48597/htb7-7xhy
title: Measurement of Pm25_mass at St. Marks

description: Measurement of Pm25_mass at St. Marks
DOI: 10.48597/j75y-r725
title: Measurement of Pm25_mass at Washington D.C.

description: Measurement of Pm25_mass at Washington D.C.
DOI: 10.48597/jkxt-8hcd
title: Measurement of Pm25_mass at St. Marks

description: Measurement of Pm25_mass at St. Marks
DOI: 10.48597/jmaw-ku25
title: Measurement of Pm25_mass at St. Marks

description: Measurement of Pm25_mass at St. Marks
DOI: 10.48597/jq7t-xjs9
title: Measurement of Pm10_mass at Washington D.C.

description: Measurement of Pm10_mass at Washington D.C.
DOI: 10.48597/jvp2-bvas
title: Measurement of Pm25_mass at Washington D.C.

description: Measurement of Pm25_mass at Washington D.C.
DOI: 10.48597/k2y4-6vpz
title: Measurement of Pm25_mass at St. Marks

description: Measurement of Pm25_mass at St. Marks
DOI: 10.48597/kdpr-r57k
title: Measurement of Pm25_mass at Weminuche Wilderness

description: Measurement of Pm25_mass at Weminuche Wilderness
DOI: 10.48597/km4h-d7wj
title: Measurement of Pm10_mass at Washington D.C.

description: Measurement of Pm10_mass at Washington D.C.
DOI: 10.48597/kqxj-rpxm
title: Measurement of Pm10_mass at Weminuche Wilderness

description: Measurement of Pm10_mass at Weminuche Wilderness
DOI: 10.48597/mu5d-zzhj
title: Measurement of Pm25_mass at Weminuche Wilderness

description: Measurement of Pm25_mass at Weminuche Wilderness
DOI: 10.48597/mvt9-dzxr
title: Measurement of Pm10_mass at Washington D.C.

description: Measurement of Pm10_mass at Washington D.C.
DOI: 10.48597/np9z-vqm6
title: Measurement of Pm10_mass at Washington D.C.

description: Measurement of Pm10_mass at Washington D.C.
DOI: 10.48597/npzt-8ksf
title: Measurement of Pm25_mass at Steamboat Springs, Colorado (Storm Peak Laboratory)

description: Measurement of Pm25_mass at Steamboat Springs, Colorado (Storm Peak Laboratory)
DOI: 10.48597/nrzj-zzbf
title: Measurement of Pm10_mass at Weminuche Wilderness

description: Measurement of Pm10_mass at Weminuche Wilderness
DOI: 10.48597/nueh-4qnm
title: Measurement of Pm10_mass at Weminuche Wilderness

description: Measurement of Pm10_mass at Weminuche Wilderness
DOI: 10.48597/pdzf-psb5
title: Measurement of Pm10_mass at Weminuche Wilderness

description: Measurement of Pm10_mass at Weminuche Wilderness
DOI: 10.48597/px9q-fdkp
title: Measurement of Pm25_mass at Washington D.C.

description: Measurement of Pm25_mass at Washington D.C.
DOI: 10.48597/qrz3-eqw7
title: Measurement of Pm25_mass at St. Marks

description: Measurement of Pm25_mass at St. Marks
DOI: 10.48597/qvnd-ujsz
title: Measurement of Pm25_mass at Washington D.C.

description: Measurement of Pm25_mass at Washington D.C.
DOI: 10.48597/r95e-u8vw
title: Measurement of Pm25_mass at Weminuche Wilderness

description: Measurement of Pm25_mass at Weminuche Wilderness
DOI: 10.48597/r9mq-m8x4
title: Measurement of Pm25_mass at Washington D.C.

description: Measurement of Pm25_mass at Washington D.C.
DOI: 10.48597/rawg-6kub
title: Measurement of Pm10_mass at Washington D.C.

description: Measurement of Pm10_mass at Washington D.C.
DOI: 10.48597/rc85-3eft
title: Measurement of Pm25_mass at St. Marks

description: Measurement of Pm25_mass at St. Marks
DOI: 10.48597/rq5w-3sg7
title: Measurement of Pm25_mass at Washington D.C.

description: Measurement of Pm25_mass at Washington D.C.
DOI: 10.48597/rzsx-jdna
title: Measurement of Pm10_mass at Washington D.C.

description: Measurement of Pm10_mass at Washington D.C.
DOI: 10.48597/s8md-acrx
title: Measurement of Pm10_mass at Washington D.C.

description: Measurement of Pm10_mass at Washington D.C.
DOI: 10.6084/m9.figshare.24925745
title: Identification of molecular subtypes and prognostic model to reveal immune infiltration and predict prognosis based on immunogenic cell death-related genes in lung adenocarcinoma

description: Immunogenic cell death (ICD) has been increasingly indicated to be related to caners. However, ICD’s role in Lung adenocarcinoma (LUAD) is still not well investigated. Clinical data along with associated mRNA expression profiles from LUAD cases were collected in TCGA and GEO databases. 13 ICD-related genes were identified. Relations of ICD-related genes expression with prognosis of patients, tumor immune microenvironment (TIME) was analyzed. Then, candidate genes were identified and the prognostic signature were constructed. Afterwards, one nomogram incorporating those chosen clinical data together with risk scores were built. Finally, the effect of HSP90AA1, one gene of the prognostic signature, on LUAD cell were analyzed. Two clusters were identified, which were designated as the ICD-high or -low subtype according to ICD-related genes levels. ICD-high subgroup showed good prognosis, high immune cell infiltration degrees, and enhanced immune response signaling activity compared with ICD-low subtype. Moreover, we established and verified the risk signature based on ICD-related genes. High risk group predicted poor prognosis of LUAD independently and presented negative association with immune score and immune status. Furthermore, nomogram contributed to the accurate prediction of LUAD prognostic outcome. Finally, HSP90AA1 levels were remarkably elevated within tumor cells in comparison with healthy pulmonary epithelial cells. HSP90α, HSP90AA1 protein product, promoted growth, migration, and invasion of LUAD cells. Molecular subtypes and prognostic model were identified by incorporating ICD-related genes, and it was related to TIME and might be adopted for the accurate prediction of LUAD prognosis.