DOI: 10.7270/q2pn95v2
title: BindingDB Entry 50032230: AC220 is a uniquely potent and selective inhibitor of FLT3 for the treatment of acute myeloid leukemia (AML).

description: Small molecule binding data for protein 3-phosphoinositide dependent protein kinase-1, 5'-AMP-activated protein kinase catalytic subunit alpha-1, AKT/p21CIP1, ALK tyrosine kinase receptor, AMPK subunit alpha-2, AXL receptor tyrosine kinase, Activin receptor type-1, Activin receptor type-1B, Activin receptor type-2A, Activin receptor type-2B, Activin receptor-like kinase 3 (ALK-3), Adaptor-associated kinase, Ankyrin repeat and protein kinase domain-containing protein 1, Apoptosis Signal-regulating Kinase 1 (ASK1), Aurora kinase B/Inner centromere protein, BMP-2-inducible protein kinase, BR serine/threonine-protein kinase 1, BR serine/threonine-protein kinase 2, Bone morphogenetic protein receptor type-1B (BMPR1B), Bone morphogenetic protein receptor type-2, C-RAF, CAMK2A, CAMK2B, CDC2-like kinase 3 (CLK3), CDK7/Cyclin H/MNAT1, CDK8/Cyclin C, CDKL2, CaM kinase I alpha, CaM kinase I delta, CaM kinase II, CaM kinase IV, CaM-kinase kinase alpha, CaM-kinase kinase beta, Casein Kinase II, Casein kinase I, Casein kinase I delta/epsilon, Casein kinase I isoform alpha (CK1 Alpha), Casein kinase I isoform delta, Casein kinase I isoform gamma-3, Casein kinase II, Cell division cycle 2-like protein kinase 6, Chaperone activity of bc1 complex-like, mitochondrial, Citron Rho-interacting kinase, Cyclin-Dependent Kinase 5 (CDK5), Cyclin-dependent kinase 11A, Cyclin-dependent kinase 15, Cyclin-dependent kinase 2, Cyclin-dependent kinase 3 (CDK3), Cyclin-dependent kinase 9, Cyclin-dependent kinase-like 3, Cyclin-dependent kinase-like 5, Death-associated protein kinase 1, Death-associated protein kinase 2, Death-associated protein kinase 3, Discoidin domain-containing receptor 2, Dual specificity mitogen-activated protein kinase kinase 1, Dual specificity mitogen-activated protein kinase kinase 2, Dual specificity mitogen-activated protein kinase kinase 3, Dual specificity mitogen-activated protein kinase kinase 4, Dual specificity mitogen-activated protein kinase kinase 6, Dual specificity protein kinase CLK2, Dual specificity protein kinase CLK4, Dual specificity protein kinase TTK, Dual specificity testis-specific protein kinase 1, Dual specificty protein kinase CLK1, Dual-specificity tyrosine-phosphorylation regulated kinase 1A, Dual-specificity tyrosine-phosphorylation regulated kinase 2, Dual-specificity tyrosine-regulated kinases 1B, EPHB1, Ephrin receptor, Ephrin type-A receptor 1 (EPHA1), Ephrin type-A receptor 3 (EPHA3), Ephrin type-B receptor 3 (EPHB3), Ephrin type-B receptor 4 (EphB4), Epidermal growth factor receptor, Epidermal growth factor receptor and ErbB2 (HER1 and HER2), Epithelial discoidin domain-containing receptor 1, Extracellular signal-regulated kinase 5 (ERK5), Fibroblast growth factor receptor 1, Fibroblast growth factor receptor 2, Fibroblast growth factor receptor 3, Fibroblast growth factor receptor 4, Focal adhesion kinase 1/vascular endothelial growth factor receptor 3, G protein-coupled receptor kinase 4, G protein-coupled receptor kinase 7, Glycogen synthase kinase-3, Hepatocyte growth factor receptor, Homeodomain-interacting protein kinase 1, Homeodomain-interacting protein kinase 2 (HIPK2), Homeodomain-interacting protein kinase 3, Homeodomain-interacting protein kinase 4, Hormonally up-regulated neu tumor-associated kinase, Human diphtheria toxin-like ADP-ribosyltransferase (ARTD6 or PARP5b), IKK epsilon/TBK1, Inhibitor of NF-kappa-B kinase (IKK), Insulin receptor, Insulin receptor-related protein, Insulin-like growth factor I receptor, Interferon-induced, double-stranded RNA-activated protein kinase, Interleukin-1 receptor-associated kinase 1, Interleukin-1 receptor-associated kinase 3, JAK2/TYK2, JAK3/JAK1, Kinesin-1 heavy chain/ Tyrosine-protein kinase receptor RET, LIM domain kinase 1, LIM domain kinase 2, Leukocyte tyrosine kinase receptor, MAP kinase ERK2, MAP kinase p38, MAP kinase signal-integrating kinase 2, MAP kinase-activated protein kinase 2, MAP kinase-activated protein kinase 5, MAP kinase-interacting serine/threonine-protein kinase MNK1, MAP/microtubule affinity-regulating kinase 2, MAP/microtubule affinity-regulating kinase 4, MAST1/MAST2, MER intracellular domain/EGFR extracellular domain chimera, Macrophage colony stimulating factor receptor, Macrophage-stimulating protein receptor, Maternal embryonic leucine zipper kinase (MELK), Misshapen-like kinase 1, Mitogen-activated protein kinase 10, Mitogen-activated protein kinase 13 (MAPK13), Mitogen-activated protein kinase 14, Mitogen-activated protein kinase 15, Mitogen-activated protein kinase 2, Mitogen-activated protein kinase 3, Mitogen-activated protein kinase 4, Mitogen-activated protein kinase 6, Mitogen-activated protein kinase 9, Mitogen-activated protein kinase kinase kinase 1, Mitogen-activated protein kinase kinase kinase 10, Mitogen-activated protein kinase kinase kinase 11, Mitogen-activated protein kinase kinase kinase 13, Mitogen-activated protein kinase kinase kinase 15, Mitogen-activated protein kinase kinase kinase 2, Mitogen-activated protein kinase kinase kinase 3, Mitogen-activated protein kinase kinase kinase 4, Mitogen-activated protein kinase kinase kinase 6, Mitogen-activated protein kinase kinase kinase 9 (MLK1), Mitogen-activated protein kinase kinase kinase kinase 1, Mitogen-activated protein kinase kinase kinase kinase 3, Mitogen-activated protein kinase kinase kinase kinase 4, Mitogen-activated protein kinase kinase kinase kinase 5, Mixed lineage kinase 7, Muscle, skeletal receptor tyrosine protein kinase, Myosin IIIA, Myosin light chain kinase family member 4, Myosin-IIIB, Myotonin-protein kinase, NT-3 growth factor receptor, NUAK family SNF1-like kinase 1, NUAK family SNF1-like kinase 2, Neurotrophic tyrosine kinase receptor, Neurotrophic tyrosine kinase receptor type 2, Non-receptor tyrosine-protein kinase TNK1, PAK1, PI3-kinase subunit alpha, PI3-kinase subunit beta, PI3-kinase subunit delta, PI3-kinase subunit gamma, PITSLRE serine/threonine-protein kinase CDC2L1, PTK2B protein tyrosine kinase 2 beta (PTK2B), Phosphatidylinositol 4-kinase beta (PIK4KB), Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing beta polypeptide, Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit gamma, Phosphatidylinositol-4-phosphate 5-kinase type-1 alpha, Phosphatidylinositol-5-phosphate 4-kinase type-2 beta, Phosphorylase kinase, Platelet-derived growth factor receptor, Platelet-derived growth factor receptor beta, Protein delta homolog 1, Protein kinase C alpha type, Protein kinase C delta type, Protein kinase C theta type, Protein kinase C, epsilon, Protein kinase C, eta, Protein kinase N1, Protein kinase N2, Proto-oncogene tyrosine-protein kinase ROS, Putative uncharacterized serine/threonine-protein kinase SgK110, RAF serine/threonine protein kinase, Receptor tyrosine-protein kinase erbB-4 (HER4), Receptor-interacting serine/threonine-protein kinase 1, Receptor-interacting serine/threonine-protein kinase 4, Rho-associated protein kinase, Rhodopsin kinase, Ribosomal protein S6 kinase (P70S6K), Ribosomal protein S6 kinase alpha 1, Ribosomal protein S6 kinase alpha 2, Ribosomal protein S6 kinase alpha 3, Ribosomal protein S6 kinase alpha 4, Ribosomal protein S6 kinase alpha 5, Ribosomal protein S6 kinase alpha 6, SM myosin light chain kinase (smMLCK), SPS1/STE20-related protein kinase YSK4, SRC, STE20/SPS1-related proline-alanine-rich protein kinase, Salt-inducible kinase 2 (SIK2), Serine/threonine protein kinase NLK, Serine/threonine-protein kinase 10, Serine/threonine-protein kinase 11, Serine/threonine-protein kinase 17A, Serine/threonine-protein kinase 17B (STK17B), Serine/threonine-protein kinase 2, Serine/threonine-protein kinase 24, Serine/threonine-protein kinase 25, Serine/threonine-protein kinase 32B, Serine/threonine-protein kinase 32C, Serine/threonine-protein kinase 33, Serine/threonine-protein kinase 35, Serine/threonine-protein kinase 36, Serine/threonine-protein kinase 38, Serine/threonine-protein kinase 38-like, Serine/threonine-protein kinase 4 (STK4), Serine/threonine-protein kinase AKT, Serine/threonine-protein kinase Aurora, Serine/threonine-protein kinase Aurora-C, Serine/threonine-protein kinase Chk1, Serine/threonine-protein kinase Chk2, Serine/threonine-protein kinase D1, Serine/threonine-protein kinase D2 (PKD2), Serine/threonine-protein kinase D3, Serine/threonine-protein kinase DCLK1, Serine/threonine-protein kinase DCLK2, Serine/threonine-protein kinase DCLK3, Serine/threonine-protein kinase GAK, Serine/threonine-protein kinase ICK, Serine/threonine-protein kinase LATS1, Serine/threonine-protein kinase LATS2, Serine/threonine-protein kinase MAK, Serine/threonine-protein kinase MARK1, Serine/threonine-protein kinase MRCK alpha, Serine/threonine-protein kinase MRCK beta, Serine/threonine-protein kinase MRCK gamma, Serine/threonine-protein kinase MST2, Serine/threonine-protein kinase MST4, Serine/threonine-protein kinase NEK6, Serine/threonine-protein kinase NEK7, Serine/threonine-protein kinase NEK9, Serine/threonine-protein kinase NIM1, Serine/threonine-protein kinase Nek1, Serine/threonine-protein kinase Nek2, Serine/threonine-protein kinase Nek5, Serine/threonine-protein kinase OSR1, Serine/threonine-protein kinase PAK 4, Serine/threonine-protein kinase PAK6, Serine/threonine-protein kinase PAK7, Serine/threonine-protein kinase PCTAIRE-1, Serine/threonine-protein kinase PCTAIRE-2, Serine/threonine-protein kinase PCTAIRE-3, Serine/threonine-protein kinase PFTAIRE-1, Serine/threonine-protein kinase PIM, Serine/threonine-protein kinase PLK1, Serine/threonine-protein kinase PLK2, Serine/threonine-protein kinase PLK3, Serine/threonine-protein kinase PLK4, Serine/threonine-protein kinase PRKX, Serine/threonine-protein kinase RIO1, Serine/threonine-protein kinase RIO2, Serine/threonine-protein kinase RIO3, Serine/threonine-protein kinase RIPK2, Serine/threonine-protein kinase SIK1, Serine/threonine-protein kinase SIK3, Serine/threonine-protein kinase SRPK1, Serine/threonine-protein kinase SRPK2, Serine/threonine-protein kinase SRPK3, Serine/threonine-protein kinase TAO1, Serine/threonine-protein kinase TAO3, Serine/threonine-protein kinase ULK1, Serine/threonine-protein kinase ULK2, Serine/threonine-protein kinase ULK3, Serine/threonine-protein kinase WEE1, Serine/threonine-protein kinase c-TAK1, Serine/threonine-protein kinase receptor R3, Serine/threonine-protein kinase tousled-like 1, Serine/threonine-protein kinase tousled-like 2, Serine/threonine-protein kinase/endoribonuclease IRE1 Alpha, TAK1/TAB1, TGF-beta receptor type I, TGF-beta receptor type II, TNNI3K, TRAF2 and NCK-interacting protein kinase (TNIK), Testis-specific serine/threonine-protein kinase 1, Tyrosine- and threonine-specific cdc2-inhibitory kinase, Tyrosine-protein kinase ABL, Tyrosine-protein kinase ABL1, Tyrosine-protein kinase BMX, Tyrosine-protein kinase BRK, Tyrosine-protein kinase BTK, Tyrosine-protein kinase Blk, Tyrosine-protein kinase CSK, Tyrosine-protein kinase CTK, Tyrosine-protein kinase FER, Tyrosine-protein kinase Fes/Fps, Tyrosine-protein kinase ITK/TSK, Tyrosine-protein kinase JAK1, Tyrosine-protein kinase JAK2, Tyrosine-protein kinase Kit (Kit), Tyrosine-protein kinase STK16 (STK16), Tyrosine-protein kinase SYK, Tyrosine-protein kinase TEC, Tyrosine-protein kinase TXK (TXK), Tyrosine-protein kinase Yes, Tyrosine-protein kinase ZAP-70, Tyrosine-protein kinase receptor FLT3, Tyrosine-protein kinase receptor TYRO3, Tyrosine-protein kinase receptor Tie-1, U4/U6 small nuclear ribonucleoprotein Prp4, Uncharacterized aarF domain-containing protein kinase 4, VEGF-receptor 2 and tyrosine-protein kinase SRC, Vascular endothelial growth factor receptor, Vascular endothelial growth factor receptor 2, Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2), Wee1-like protein kinase 2, c-Jun N-terminal kinase, JNK, cAMP-dependent protein kinase (PKA), cGMP-dependent protein kinase, cGMP-dependent protein kinase 2, myosin light chain kinase 2, p21-Activated kinase 2 (PAK2), p21-Activated kinase 3 (PAK3), and p38 delta/gamma, Uniprot A0A024RDK3, L7RSL3, O00238, O00329, O00444, O00506, O00750, O14578, O14730, O14757, O14920, O14965, O14976, O15075, O15111, O15146, O15197, O15264, O15530, O43172, O43283, O43293, O43318, O43353, O60285, O60674, O75116, O75385, O75460, O75582, O75676, O75716, O75747, O75914, O76039, O94768, O94804, O94806, O94921, O95382, O95747, O95819, O95835, O96013, O96017, P00519, P00533, P04049, P04626, P04629, P06213, P06239, P06241, P07332, P07333, P07947, P07948, P07949, P08069, P08581, P08631, P08922, P09619, P09769, P0C1S8, P0C264, P10721, P11309, P11362, P12931, P14616, P15056, P15735, P16234, P16591, P17252, P17948, P19525, P19784, P20794, P21127, P21709, P21802, P21860, P22455, P22607, P22694, P23443, P23458, P24723, P24941, P27037, P27361, P27448, P28482, P29317, P29320, P29322, P29323, P29376, P29597, P30291, P30530, P31152, P31749, P31751, P32298, P33981, P35590, P35916, P35968, P36507, P36888, P36894, P36896, P36897, P37023, P37173, P41240, P42336, P42338, P42679, P42680, P42681, P42684, P42685, P43403, P43405, P45983, P45984, P45985, P46734, P48729, P48730, P48736, P49137, P49336, P49674, P49759, P49760, P49761, P49840, P49841, P50613, P50750, P51451, P51617, P51812, P51813, P51817, P51955, P52333, P52564, P53350, P53355, P53667, P53671, P53778, P53779, P54646, P54753, P54756, P54760, P54762, P54764, P57058, P57059, P57078, P68400, P78356, P78362, P78368, P80192, P80370, Q00526, Q00535, Q00536, Q00537, Q02156, Q02750, Q02763, Q02779, Q04759, Q04771, Q04912, Q05397, Q05655, Q06187, Q06418, Q08345, Q08881, Q09013, Q12851, Q12866, Q13043, Q13131, Q13153, Q13164, Q13177, Q13188, Q13233, Q13237, Q13464, Q13470, Q13546, Q13554, Q13555, Q13557, Q13627, Q13705, Q13873, Q13882, Q13976, Q14012, Q14164, Q14289, Q14680, Q15139, Q15208, Q15303, Q15349, Q15418, Q15569, Q15746, Q15759, Q15831, Q15835, Q16288, Q16512, Q16513, Q16539, Q16566, Q16584, Q16620, Q16659, Q16816, Q16832, Q2M2I8, Q541P7, Q56UN5, Q59H18, Q5VT25, Q6DT37, Q6FI23, Q6P3R8, Q6PHR2, Q6ZN16, Q7KZI7, Q7L7X3, Q86UE8, Q86UX6, Q86V86, Q86YV6, Q86Z02, Q8IU85, Q8IVH8, Q8IVW4, Q8IW41, Q8IWQ3, Q8IY84, Q8IYT8, Q8N4C8, Q8N568, Q8N5S9, Q8NE63, Q8NEV4, Q8NFD2, Q8NI60, Q8TD08, Q8TD19, Q8TDC3, Q8TDR2, Q8TDX7, Q8WTQ7, Q8WXR4, Q92630, Q92772, Q92918, Q96D53, Q96GD4, Q96L34, Q96PY6, Q96Q40, Q96RR4, Q96SB4, Q99640, Q99683, Q99755, Q99759, Q9BRS2, Q9BUB5, Q9BVS4, Q9BWU1, Q9BXA7, Q9BYT3, Q9BZL6, Q9C098, Q9H093, Q9H0K1, Q9H1R3, Q9H2G2, Q9H2K2, Q9H2K8, Q9H2X6, Q9H3Y6, Q9H422, Q9H4B4, Q9HAZ1, Q9HBH9, Q9HC98, Q9HCP0, Q9NQU5, Q9NRM7, Q9NRP7, Q9NSY1, Q9NY57, Q9NYL2, Q9NYY3, Q9P0L2, Q9P1W9, Q9P286, Q9P289, Q9UBE8, Q9UBF8, Q9UEE5, Q9UEW8, Q9UF33, Q9UHD2, Q9UIK4, Q9UK32, Q9UKE5, Q9UKI8, Q9UM73, Q9UPE1, Q9UPZ9, Q9UQ88, Q9UQB9, Q9UQM7, Q9Y243, Q9Y2H1, Q9Y2H9, Q9Y2U5, Q9Y463, Q9Y5S2, Q9Y616, Q9Y6E0, Q9Y6M4, and Q9Y6R4