cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.7677359.v1
title: Umbilical Cord Blood Gas Analysis, Obstetric Performance and Perinatal Outcome

description: Abstract Objective To analyze if umbilical artery pH (pHua) ≤7.00 and umbilical artery blood deficit (BDua) ≥12.00 mmol/L are good predictors of adverse neonatal outcomes. Methods This was an observational, longitudinal and retrospective cohort study, conducted at the department of obstetrics and gynecology of Centro Hospitalar Tondela Viseu between September 2013 and September 2015. Total cohort and subgroup analysis were performed: group A-women with umbilical cord blood gas analysis (UCBGA) performed for non-reassuring fetal cardiotocographic patterns, placental abruption, or shoulder dystocia; and group B-all the others. Assays were made with the software SPSS for Windows, Versions 20.0 and 21.0 (IBM Corp., Armonk, NY, USA). Results A total of 428 UCBGAs met the inclusion criteria. The group analysis revealed an association between group A and pHua ≤7.00, as well as between BDua ≥12.00 mmol/L and 1st minute Apgar score ≤4 (p = 0.011). After the application of the logistic regression models in the total cohort analysis, pHua ≤7.00 had an impact in the occurrence of acute neonatal hypoxia (odds ratio [OR]: 6.71; 95% confidence interval [CI]: 1.21-37.06; p = 0.029); multiparous women had a higher risk of delivering a newborn with first minute Apgar score ≤4 and acute neonatal hypoxia (OR: 5.38; 95% CI: 1.35-21.43; p = 0.017; and OR: 2.66; 95% CI: 1.03-6.89, p = 0.043, respectively); women who had urologic problems during pregnancy had a higher risk of delivering a newborn with 5th minute Apgar score ≤7 (OR: 15.17; 95% CI: 1.29-177.99; p = 0.030); and shoulder dystocia represented a 15 times higher risk of acute neonatal hypoxia (OR: 14.82; 95% CI: 2.20-99.60; p = 0.006). Conclusion The pHua and the BDua are predictors of adverse neonatal outcome, and UCBGA is a useful tool for screening newborns at risk. Universal UCBGA should be considered for all deliveries, as it is an accurate screening test for neonatal hypoxia.
DOI: 10.6084/m9.figshare.7677356
title: Cytotoxic and pro-apoptotic action of MjTX-I, a phospholipase A2 isolated from Bothrops moojeni snake venom, towards leukemic cells

description: Abstract Background: Chronic myeloid leukemia (CML) is a BCR-ABL1+ myeloproliferative neoplasm marked by increased myeloproliferation and presence of leukemic cells resistant to apoptosis. The current first-line therapy for CML is administration of the tyrosine kinase inhibitors imatinib mesylate, dasatinib or nilotinib. Although effective to treat CML, some patients have become resistant to this therapy, leading to disease progression and death. Thus, the discovery of new compounds to improve CML therapy is still challenging. Here we addressed whether MjTX-I, a phospholipase A2 isolated from Bothrops moojeni snake venom, affects the viability of imatinib mesylate-resistant Bcr-Abl+ cell lines. Methods: We examined the cytotoxic and pro-apoptotic effect of MjTX-I in K562-S and K562-R Bcr-Abl+ cells and in the non-tumor HEK-293 cell line and peripheral blood mononuclear cells, using the 3-(4,5-dimethylthiazol-2-yl) −2,5-diphenyltetrazolium bromide and the hypotonic fluorescent solution methods, associated with detection of caspases 3, 8, and 9 activation and poly (ADP-ribose) polymerase (PARP) cleavage. We also analyzed the MjTX-I potential to modulate the expression of apoptosis-related genes in K562-S and K562-R cells. Results: MjTX-I decreased the viability of K562-S and K562-R cells by 60 to 65%, without affecting the viability of the non-tumor cells, i.e. it exerted selective cytotoxicity towards Bcr-Abl+ cell lines. In leukemic cell lines, the toxin induced apoptosis, activated caspases 3, 8, and 9, cleaved PARP, downregulated expression of the anti-apoptotic gene BCL-2, and upregulated expression of the pro-apoptotic gene BAD. Conclusion: The antitumor effect of MjTX-I is associated with its potential to induce apoptosis and cytotoxicity in Bcr-Abl positive cell lines sensitive and resistant to imatinib mesylate, indicating that MjTX-I is a promising candidate drug to upgrade the CML therapy.
DOI: 10.6084/m9.figshare.7677362.v1
title: Cardiovascular Disease Epidemiology in Portuguese-Speaking Countries: data from the Global Burden of Disease, 1990 to 2016

description: Abstract Background: Portuguese-speaking countries (PSC) share the influence of the Portuguese culture but have socioeconomic development patterns that differ from that of Portugal. Objective: To describe trends in cardiovascular disease (CVD) morbidity and mortality in the PSC between 1990 and 2016, stratified by sex, and their association with the respective sociodemographic indexes (SDI). Methods: This study used the Global Burden of Disease (GBD) 2016 data and methodology. Data collection followed international standards for death certification, through information systems on vital statistics and mortality surveillance, surveys, and hospital registries. Techniques were used to standardize causes of death by the direct method, as were corrections for underreporting of deaths and garbage codes. To determine the number of deaths due to each cause, the CODEm (Cause of Death Ensemble Model) algorithm was applied. Disability-adjusted life years (DALYs) and SDI (income per capita, educational attainment and total fertility rate) were estimated for each country. A p-value &lt;0.05 was considered significant. Results: There are large differences, mainly related to socioeconomic conditions, in the relative impact of CVD burden in PSC. Among CVD, ischemic heart disease was the leading cause of death in all PSC in 2016, except for Mozambique and Sao Tome and Principe, where cerebrovascular diseases have supplanted it. The most relevant attributable risk factors for CVD among all PSC are hypertension and dietary factors. Conclusion: Collaboration among PSC may allow successful experiences in combating CVD to be shared between those countries.
DOI: 10.7284/119002
title: GNSS (Global Navigation Satellite System) data collected during research cruise BH14-06 using a Northstar 941X instrument system onboard the platform RV Blue Heron

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7677350
title: Development of Poly (butylene adipate-co-terephthalate) Filled with Montmorillonite-Polypyrrole for Pressure Sensor Applications

description: A novel pressure sensing material composed of poly (butylene adipate-co-terephthalate) (PBAT) and montmorillonite-polypyrrole (Mt-PPy) was prepared using melt mixing and injection molding. The structure and properties of the PBAT/Mt-PPy composites were evaluated and compared with those of the PBAT/PPy blends. The PBAT/Mt-PPy displays a very sharp insulator-conductor transition and its percolation threshold was reached at 6.5 wt% of Mt-PPy, which was lower than that for PBAT/PPy (11.0 wt% of PPy). The transmission electron microscopy analysis shows that Mt-PPy displays a high aspect ratio and was better distributed and dispersed into PBAT compared to PPy. PBAT/Mt-PPy exhibits a decrease in the electrical resistivity with an applied compressive stress due to the formation of new conducting pathways. The electromechanical response was dependent on Mt-PPy and the maximum sensitivity was observed for the composite containing 10 wt% of Mt-PPy. In this system, the electrical resistivity drops from 9 x 106 to 2 x 106 Ω cm when a compressive stress of 0.25 MPa was applied. The electrical resistivity changes with applied compressive stress, the reproducibility and the reversibility makes PBAT/Mt-PPy a suitable material for the development of pressure sensors.
DOI: 10.6084/m9.figshare.7677353
title: Macrophage migration inhibitory factor antagonist (p425) ameliorates kidney histopathological and functional changes in diabetic rats

description: Abstract Introduction: It is hypothesized that increased macrophage migration inhibitory factor (MIF) expression may contribute to diabetic nephropathy (DN) pathogenesis. The aim of the present study was to investigate the renal effects of MIF inhibition in a diabetic experimental model. Methods: Eighteen male Wistar rats (230 ± 20 g) were divided into three groups: 1) control, 2) diabetic (STZ, 50 mg/kg, dissolved in saline, ip), 3) diabetic + MIF antagonist (p425, 1 mg/kg per day, ip, on the 21th day, for 21 consecutive days). The treatment started since we founwd a significant increase in urine albumin excretion (UAE) rate in the diabetic rats in comparison with the control rats. The rats were kept individually in metabolic cages (8 AM-2 PM) and urine samples were collected in the 21 and 42th day. At the end, blood and tissue samples were collected for biochemical (BS, UPE, urine GAG, BUN, Cr, Na, and K) and histological analyses. Results: The results of this study showed that MIF antagonist (p425) significantly decreased urine protein and GAG excretion, urine protein/creatinine ratio, and serum BUN and Cr in the streptozotocin-induced DN in the rats. Pathological changes were significantly alleviated in the MIF antagonist (p425)-administered DN rats. Conclusion: Collectively, these data suggested that MIF antagonist (p425) was able to protect against functional and histopathological injury in the DN.
DOI: 10.6084/m9.figshare.7677356.v1
title: Cytotoxic and pro-apoptotic action of MjTX-I, a phospholipase A2 isolated from Bothrops moojeni snake venom, towards leukemic cells

description: Abstract Background: Chronic myeloid leukemia (CML) is a BCR-ABL1+ myeloproliferative neoplasm marked by increased myeloproliferation and presence of leukemic cells resistant to apoptosis. The current first-line therapy for CML is administration of the tyrosine kinase inhibitors imatinib mesylate, dasatinib or nilotinib. Although effective to treat CML, some patients have become resistant to this therapy, leading to disease progression and death. Thus, the discovery of new compounds to improve CML therapy is still challenging. Here we addressed whether MjTX-I, a phospholipase A2 isolated from Bothrops moojeni snake venom, affects the viability of imatinib mesylate-resistant Bcr-Abl+ cell lines. Methods: We examined the cytotoxic and pro-apoptotic effect of MjTX-I in K562-S and K562-R Bcr-Abl+ cells and in the non-tumor HEK-293 cell line and peripheral blood mononuclear cells, using the 3-(4,5-dimethylthiazol-2-yl) −2,5-diphenyltetrazolium bromide and the hypotonic fluorescent solution methods, associated with detection of caspases 3, 8, and 9 activation and poly (ADP-ribose) polymerase (PARP) cleavage. We also analyzed the MjTX-I potential to modulate the expression of apoptosis-related genes in K562-S and K562-R cells. Results: MjTX-I decreased the viability of K562-S and K562-R cells by 60 to 65%, without affecting the viability of the non-tumor cells, i.e. it exerted selective cytotoxicity towards Bcr-Abl+ cell lines. In leukemic cell lines, the toxin induced apoptosis, activated caspases 3, 8, and 9, cleaved PARP, downregulated expression of the anti-apoptotic gene BCL-2, and upregulated expression of the pro-apoptotic gene BAD. Conclusion: The antitumor effect of MjTX-I is associated with its potential to induce apoptosis and cytotoxicity in Bcr-Abl positive cell lines sensitive and resistant to imatinib mesylate, indicating that MjTX-I is a promising candidate drug to upgrade the CML therapy.
DOI: 10.6084/m9.figshare.7677353.v1
title: Macrophage migration inhibitory factor antagonist (p425) ameliorates kidney histopathological and functional changes in diabetic rats

description: Abstract Introduction: It is hypothesized that increased macrophage migration inhibitory factor (MIF) expression may contribute to diabetic nephropathy (DN) pathogenesis. The aim of the present study was to investigate the renal effects of MIF inhibition in a diabetic experimental model. Methods: Eighteen male Wistar rats (230 ± 20 g) were divided into three groups: 1) control, 2) diabetic (STZ, 50 mg/kg, dissolved in saline, ip), 3) diabetic + MIF antagonist (p425, 1 mg/kg per day, ip, on the 21th day, for 21 consecutive days). The treatment started since we founwd a significant increase in urine albumin excretion (UAE) rate in the diabetic rats in comparison with the control rats. The rats were kept individually in metabolic cages (8 AM-2 PM) and urine samples were collected in the 21 and 42th day. At the end, blood and tissue samples were collected for biochemical (BS, UPE, urine GAG, BUN, Cr, Na, and K) and histological analyses. Results: The results of this study showed that MIF antagonist (p425) significantly decreased urine protein and GAG excretion, urine protein/creatinine ratio, and serum BUN and Cr in the streptozotocin-induced DN in the rats. Pathological changes were significantly alleviated in the MIF antagonist (p425)-administered DN rats. Conclusion: Collectively, these data suggested that MIF antagonist (p425) was able to protect against functional and histopathological injury in the DN.
DOI: 10.7284/119003
title: GNSS (Global Navigation Satellite System) data collected during research cruise BH14-07 using a Northstar 941X instrument system onboard the platform RV Blue Heron

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7677341
title: Quality of life of individuals with chronic kidney disease on dialysis

description: Abstract Introduction: Chronic kidney disease (CKD) negatively affects the physical and biopsychosocial aspects of the lives of individuals with the disease, thereby affecting the quality of life (QOL) of patients and their families. Objectives: This study aimed to measure the QOL of individuals with CKD and compare the QOL scores of patients with CKD to the scores of disease-free individuals to find factors associated with better QOL. Method: The local Ethics Committee approved this cross-sectional study. The study was carried out at a public clinic and a private hemodialysis clinic. Participants were asked to answer the WHOQOL-BREF and a sociodemographic questionnaire. Statistical tests were used according to the variables of interest and significance was attributed to differences with p-values &lt; 0.05. Results: Nearly two thirds (59%) of the case group members were males and 55% did not have a spouse; 53% were seen at a private clinic and 57% had complications. The variables that more significantly affected QOL were smoking (perception of QOL) (Bi = - 0.4061; p = 0.032), undergoing hemodialysis (general health status) (Bi = - 0.3029; p = 0.034), and duration of sessions (Bi = 0.117; p = 0.039) (environmental domain). Conclusion: The QOL of patients with CKD was significantly lower when compared to controls in the physical and psychological domains. Several variables affected the perception of QOL and should be considered in clinical assessment.
DOI: 10.6084/m9.figshare.7677350.v1
title: Development of Poly (butylene adipate-co-terephthalate) Filled with Montmorillonite-Polypyrrole for Pressure Sensor Applications

description: A novel pressure sensing material composed of poly (butylene adipate-co-terephthalate) (PBAT) and montmorillonite-polypyrrole (Mt-PPy) was prepared using melt mixing and injection molding. The structure and properties of the PBAT/Mt-PPy composites were evaluated and compared with those of the PBAT/PPy blends. The PBAT/Mt-PPy displays a very sharp insulator-conductor transition and its percolation threshold was reached at 6.5 wt% of Mt-PPy, which was lower than that for PBAT/PPy (11.0 wt% of PPy). The transmission electron microscopy analysis shows that Mt-PPy displays a high aspect ratio and was better distributed and dispersed into PBAT compared to PPy. PBAT/Mt-PPy exhibits a decrease in the electrical resistivity with an applied compressive stress due to the formation of new conducting pathways. The electromechanical response was dependent on Mt-PPy and the maximum sensitivity was observed for the composite containing 10 wt% of Mt-PPy. In this system, the electrical resistivity drops from 9 x 106 to 2 x 106 Ω cm when a compressive stress of 0.25 MPa was applied. The electrical resistivity changes with applied compressive stress, the reproducibility and the reversibility makes PBAT/Mt-PPy a suitable material for the development of pressure sensors.
DOI: 10.7284/119004
title: GNSS (Global Navigation Satellite System) data collected during research cruise BH14-08 using a Northstar 941X instrument system onboard the platform RV Blue Heron

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7677335
title: Association between Caffeine Consumption in Pregnancy and Low Birth Weight and Preterm Birth in the birth Cohort of Ribeirão Preto

description: Abstract Objective To describe caffeine consumption during pregnancy and its association with low birth weight (LBW) and preterm birth in the birth cohort of Ribeirão Preto, state of São Paulo, Brazil, in 2010. Methods Cohort study, with descriptive and analytical approach. Data included 7,607 women and their newborns in Ribeirão Preto, state of São Paulo, Brazil. The women answered standardized questionnaires about reproductive health, prenatal care, life habits, sociodemographic conditions, and information about coffee intake. The independent variable was high caffeine consumption (≥300 mg/day) from coffee during pregnancy, and the dependent variables were LBW (birth weight &lt; 2,500 g) and preterm birth (&lt; 37 weeks of gestational age). Four adjusted polytomous logistic regression models, relative risk (RR) and 95% confidence interval (CI) were fitted: biological and sociodemographic conditions; obstetric history; current gestational conditions; and all variables included in the previous models. Results A total of 4,908 (64.5%) mothers consumed caffeine, 143 (2.9%) of whom reported high consumption. High caffeine intake was significantly associated with reduced education and with the occupation of the head of the family, nonwhite skin color, not having a partner, higher parity, previous abortion and preterm birth, urinary tract infection, threatened abortion, alcohol consumption and smoking. No association was found between high caffeine consumption and LBW or preterm birth in both Conclusion In this cohort, high caffeine intake was lower than in other studies and no association with LBW or preterm birth was found.
DOI: 10.6084/m9.figshare.7677341.v1
title: Quality of life of individuals with chronic kidney disease on dialysis

description: Abstract Introduction: Chronic kidney disease (CKD) negatively affects the physical and biopsychosocial aspects of the lives of individuals with the disease, thereby affecting the quality of life (QOL) of patients and their families. Objectives: This study aimed to measure the QOL of individuals with CKD and compare the QOL scores of patients with CKD to the scores of disease-free individuals to find factors associated with better QOL. Method: The local Ethics Committee approved this cross-sectional study. The study was carried out at a public clinic and a private hemodialysis clinic. Participants were asked to answer the WHOQOL-BREF and a sociodemographic questionnaire. Statistical tests were used according to the variables of interest and significance was attributed to differences with p-values &lt; 0.05. Results: Nearly two thirds (59%) of the case group members were males and 55% did not have a spouse; 53% were seen at a private clinic and 57% had complications. The variables that more significantly affected QOL were smoking (perception of QOL) (Bi = - 0.4061; p = 0.032), undergoing hemodialysis (general health status) (Bi = - 0.3029; p = 0.034), and duration of sessions (Bi = 0.117; p = 0.039) (environmental domain). Conclusion: The QOL of patients with CKD was significantly lower when compared to controls in the physical and psychological domains. Several variables affected the perception of QOL and should be considered in clinical assessment.
DOI: 10.6084/m9.figshare.7677332
title: Aeration frequency on accelerated composting of animal carcasses

description: ABSTRACT Rotary drum reactors (RDRs) for accelerated carcass composting are being installed in animal production units as an alternative for the disposal of pig and poultry carcasses in Brazil. The aim of the present study was to investigate the influence of aeration frequency on gas emissions (CO2-C, CH4-C, NH3-N and N2O-N) during composting of pig and poultry carcasses in RDRs. RDRs with a volume of 3.6 m3 (50% useful volume) were used. Aeration time was 24 minutes. Four intervals between aeration periods were tested (treatments) as follows: 1 hour (T1), 2 hours (T2), 3 hours (T3) and 4 hours (T4). Gas emissions were continuously monitored using a photoacoustic gas monitor (INNOVA 1412). Temperature was monitored using iButtons mixed with the biomass. Mathematical models of CO2-C and NH3-N emissions relative to the observed biomass temperature were proposed. Biomass temperature was affected by the treatments. The highest aeration frequency had the shortest thermophilic phase (&gt;50 °C). No significant differences in total gas emissions were observed between treatments (p&gt;0.05). CO2-C and NH3-N emissions were better fitted by non-linear models (R2=0.75 and R2=0.78, respectively). A minimum 2-hour interval should be adopted between aeration periods of 24 minutes to guarantee a longer thermophilic phase and elimination of possible pathogenic contaminants.
DOI: 10.6084/m9.figshare.7677329
title: CHEMICAL REACTION OPTIMIZATION METAHEURISTIC FOR LOCATING SERVICE STATIONS THROUGH THE CAPACITATED P-MEDIAN PROBLEM

description: ABSTRACT Chemical Reaction Optimization (CRO) is a metaheuristic for solving optimization problems, which mimics the interactions between molecules in a chemical reaction with the purpose of achieving a stable, low-energy state. In the present work, we utilize the CRO metaheuristic to solve, in an efficient manner, the capacitated p-median problem, in order to locate service stations. Results from solving small to medium-sized problems available in the literature, with up to 724 notes and 200 medians, are compared to their optimal or best-known values. Results show that CRO results are comparable, in terms of accuracy and execution time, to many existing successfulmetaheuristics, as well as exact and hybrid methods, having exceeding those in some cases.
DOI: 10.6084/m9.figshare.7677332.v1
title: Aeration frequency on accelerated composting of animal carcasses

description: ABSTRACT Rotary drum reactors (RDRs) for accelerated carcass composting are being installed in animal production units as an alternative for the disposal of pig and poultry carcasses in Brazil. The aim of the present study was to investigate the influence of aeration frequency on gas emissions (CO2-C, CH4-C, NH3-N and N2O-N) during composting of pig and poultry carcasses in RDRs. RDRs with a volume of 3.6 m3 (50% useful volume) were used. Aeration time was 24 minutes. Four intervals between aeration periods were tested (treatments) as follows: 1 hour (T1), 2 hours (T2), 3 hours (T3) and 4 hours (T4). Gas emissions were continuously monitored using a photoacoustic gas monitor (INNOVA 1412). Temperature was monitored using iButtons mixed with the biomass. Mathematical models of CO2-C and NH3-N emissions relative to the observed biomass temperature were proposed. Biomass temperature was affected by the treatments. The highest aeration frequency had the shortest thermophilic phase (&gt;50 °C). No significant differences in total gas emissions were observed between treatments (p&gt;0.05). CO2-C and NH3-N emissions were better fitted by non-linear models (R2=0.75 and R2=0.78, respectively). A minimum 2-hour interval should be adopted between aeration periods of 24 minutes to guarantee a longer thermophilic phase and elimination of possible pathogenic contaminants.