cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.1577601
title: Waterpipe effects on pulmonary function and cardiovascular indices: a comparison to cigarette smoking in real life situation

description: <i>Introduction</i>: Smoking is known to have physiological effects on biological systems. The purpose of this study is to evaluate acute and chronic effects on pulmonary functions and cardiovascular indices of waterpipe (WP) smoking in real life circumstances.<i>Methods</i>: Three groups were included in the study: non-smokers (<i>N</i> = 42), WP smokers (<i>N</i> = 42) and cigarette smokers (<i>N</i> = 48). A questionnaire was completed for each participant, in addition to pulmonary function [forced expiratory volume at 1 s (FEV<sub>1</sub>), 6 s (FEV<sub>6</sub>), percentage of FEV<sub>1</sub>/FEV<sub>6</sub>], and cardiovascular [diastolic blood pressure (DBP), systolic blood pressure (SBP) and heart rate (HR)] measures, taken before and after smoking.<i>Results</i>: Mean values of FEV<sub>1</sub>, FEV<sub>6</sub>, FEV<sub>1</sub>/FEV<sub>6</sub>, DBP and SBP in WP and cigarette smokers were very close. However, WP smoking significantly increased HR compared to cigarette smokers (<i>p</i> = 0.007); duration of smoking, age at first WP and quantity of smoking affected pulmonary function and cardiovascular values. In the subgroup of WP smokers, DBP was acutely increased by a larger WP size (<i>p</i> = 0.011), while the FEV<sub>6</sub> was acutely increased by a smaller WP size (<i>p</i> = 0.045).<i>Conclusion</i>: WP smoking affected the cardiovascular system more than cigarette smoking, while it had similar effects on pulmonary function.
DOI: 10.6084/m9.figshare.1577602.v1
title: Use of novel inhalation kinetic studies to refine physiologically-based pharmacokinetic models for ethanol in non-pregnant and pregnant rats

description: Ethanol (EtOH) exposure induces a variety of concentration-dependent neurological and developmental effects in the rat. Physiologically-based pharmacokinetic (PBPK) models have been used to predict the inhalation exposure concentrations necessary to produce blood EtOH concentrations (BEC) in the range associated with these effects. Previous laboratory reports often lacked sufficient detail to adequately simulate reported exposure scenarios associated with BECs in this range, or lacked data on the time-course of EtOH in target tissues (e.g. brain, liver, eye, fetus). To address these data gaps, inhalation studies were performed at 5000, 10 000, and 21 000 ppm (6 h/d) in non-pregnant female Long-Evans (LE) rats and at 21 000 ppm (6.33 h/d) for 12 d of gestation in pregnant LE rats to evaluate our previously published PBPK models at toxicologically-relevant blood and tissue concentrations. Additionally, nose-only and whole-body plethysmography studies were conducted to refine model descriptions of respiration and uptake within the respiratory tract. The resulting time-course and plethysmography data from these <i>in vivo</i> studies were compared to simulations from our previously published models, after which the models were recalibrated to improve descriptions of tissue dosimetry by accounting for dose-dependencies in pharmacokinetic behavior. Simulations using the recalibrated models reproduced these data from non-pregnant, pregnant, and fetal rats to within a factor of 2 or better across datasets, resulting in a suite of model structures suitable for simulation of a broad range of EtOH exposure scenarios.
DOI: 10.6084/m9.figshare.1577599
title: Brain suppression of AP-1 by inhaled diesel exhaust and reversal by cerium oxide nanoparticles

description: One of the uses of cerium oxide nanoparticles (nanoceria, CeO<sub>2</sub>) is as a diesel fuel additive to improve fuel efficiency. Gene/environment interactions are important determinants in the etiology of age-related disorders. Thus, it is possible that individuals on high-fat diet and genetic predisposition to vascular disease may be more vulnerable to the adverse health effects of particle exposure. The aim of this pilot study was to test the hypothesis that inhalation of diesel exhaust (DE) or diesel exhaust-containing cerium oxide nanoparticles (DCeE) induces stress in the brain of a susceptible animal model. Atherosclerotic prone, apolipoprotein E knockout (ApoE<sup>−/−</sup>) mice fed a high-fat diet, were exposed by inhalation to purified air (control), DE or DCeE. The stress-responsive transcription factor, activator protein-1 (AP-1), was significantly decreased in the cortical and subcortical fraction of the brain after DE exposure. The addition of nanoceria to the diesel fuel reversed this effect. The activation of another stress-related transcription factor (NF-κB) was not inhibited. AP-1 is composed of complexes of the Jun and/or Fos family of proteins. Exposure to DCeE caused c-Jun activation and this may be a mechanism by which addition of nanoceria to the fuel reversed the effect of DE exposure on AP-1 activation. This pilot study demonstrates that exposure to DE does impact the brain and addition of nanoceria may be protective. However, more extensive studies are necessary to determine how DE induced reduction of AP-1 activity and compensation by nanoceria impacts normal function of the brain.
DOI: 10.6084/m9.figshare.1577600
title: The acute exposure effects of inhaled nickel nanoparticles on murine endothelial progenitor cells

description: <i>Introduction</i>: The discovery of endothelial progenitor cells (EPCs) may help to explain observed cardiovascular effects associated with inhaled nickel nanoparticle exposures, such as increases in vascular inflammation, generation of reactive oxygen species, altered vasomotor tone and potentiated atherosclerosis in murine species.<i>Methods</i>: Following an acute whole body inhalation exposure to 500 µg/m<sup>3</sup> of nickel nanoparticles for 5 h, bone marrow EPCs from C57BL/6 mice were isolated. EPCs were harvested for their RNA or used in a variety of assays including chemotaxis, tube formation and proliferation. Gene expression was assessed for important receptors involved in EPC mobilization and homing using RT-PCR methods. EPCs, circulating endothelial progenitor cells (CEPCs), circulating endothelial cells (CECs) and endothelial microparticles (EMPs) were quantified on a BD FACSCalibur to examine endothelial damage and repair associated with the exposure.<i>Results and conclusions</i>: Acute exposure to inhaled nickel nanoparticles significantly increased both bone marrow EPCs as well as their levels in circulation (CEPCs). CECs were significantly elevated indicating that endothelial damage occurred due to the exposure. There was no significant difference in EMPs between the two groups. Tube formation and chemotaxis, but not proliferation, of bone marrow EPCs was impaired in the nickel nanoparticle exposed group. These results coincided with a decrease in the mRNA of receptors involved in EPC mobilization and homing. These data provide new insight into how an acute nickel nanoparticle exposure to half of the current Occupational Safety & Health Administration (OSHA) permissible exposure limit may adversely affect EPCs and exacerbate cardiovascular disease states.
DOI: 10.6084/m9.figshare.1577601.v1
title: Waterpipe effects on pulmonary function and cardiovascular indices: a comparison to cigarette smoking in real life situation

description: <i>Introduction</i>: Smoking is known to have physiological effects on biological systems. The purpose of this study is to evaluate acute and chronic effects on pulmonary functions and cardiovascular indices of waterpipe (WP) smoking in real life circumstances.<i>Methods</i>: Three groups were included in the study: non-smokers (<i>N</i> = 42), WP smokers (<i>N</i> = 42) and cigarette smokers (<i>N</i> = 48). A questionnaire was completed for each participant, in addition to pulmonary function [forced expiratory volume at 1 s (FEV<sub>1</sub>), 6 s (FEV<sub>6</sub>), percentage of FEV<sub>1</sub>/FEV<sub>6</sub>], and cardiovascular [diastolic blood pressure (DBP), systolic blood pressure (SBP) and heart rate (HR)] measures, taken before and after smoking.<i>Results</i>: Mean values of FEV<sub>1</sub>, FEV<sub>6</sub>, FEV<sub>1</sub>/FEV<sub>6</sub>, DBP and SBP in WP and cigarette smokers were very close. However, WP smoking significantly increased HR compared to cigarette smokers (<i>p</i> = 0.007); duration of smoking, age at first WP and quantity of smoking affected pulmonary function and cardiovascular values. In the subgroup of WP smokers, DBP was acutely increased by a larger WP size (<i>p</i> = 0.011), while the FEV<sub>6</sub> was acutely increased by a smaller WP size (<i>p</i> = 0.045).<i>Conclusion</i>: WP smoking affected the cardiovascular system more than cigarette smoking, while it had similar effects on pulmonary function.
DOI: 10.6084/m9.figshare.1577598
title: Central and peripheral cardiovascular changes immediately after waterpipe smoking

description: <i>Background</i>: Tobacco cigarette smoking is a global health problem that kills millions each year. Recently, tobacco smoking using a waterpipe (WP) has become popular worldwide. However, unlike cigarettes, the cardiovascular (CV) risks associated with WP smoking are uncertain. In this study, the immediate effects of WP smoking on central and peripheral CV indices were evaluated in 53 young healthy smokers.<i>Materials and methods</i>: Strain-gauge plethysmography was used to measure forearm blood flow (Bf), vascular resistance (Vr), and venous capacitance (Vc) and outflow (Vf) at rest (R) and after occlusion (Oc), whereas heart rate (HR) and blood pressure (BP) were measured using standard automated auscultatory methods immediately before and after a 30-min WP smoking session.<i>Results</i>: Smoking resulted in HR, diastolic BP, mean arterial BP, rate pressure product and OcVr increases (<i>p</i> p p <i>Conclusion</i>: These results demonstrated changes in the CV central and peripheral components immediately after WP smoking. The correlations between the changes in these components suggest that the periphery is controlled, at least partially, by the same mechanism(s) affecting the central CV components during WP smoking.
DOI: 10.6084/m9.figshare.1577614.v2
title: MDV files for alaising study

description: Please download from ARM archive
DOI: 10.6084/m9.figshare.1577600.v1
title: The acute exposure effects of inhaled nickel nanoparticles on murine endothelial progenitor cells

description: <i>Introduction</i>: The discovery of endothelial progenitor cells (EPCs) may help to explain observed cardiovascular effects associated with inhaled nickel nanoparticle exposures, such as increases in vascular inflammation, generation of reactive oxygen species, altered vasomotor tone and potentiated atherosclerosis in murine species.<i>Methods</i>: Following an acute whole body inhalation exposure to 500 µg/m<sup>3</sup> of nickel nanoparticles for 5 h, bone marrow EPCs from C57BL/6 mice were isolated. EPCs were harvested for their RNA or used in a variety of assays including chemotaxis, tube formation and proliferation. Gene expression was assessed for important receptors involved in EPC mobilization and homing using RT-PCR methods. EPCs, circulating endothelial progenitor cells (CEPCs), circulating endothelial cells (CECs) and endothelial microparticles (EMPs) were quantified on a BD FACSCalibur to examine endothelial damage and repair associated with the exposure.<i>Results and conclusions</i>: Acute exposure to inhaled nickel nanoparticles significantly increased both bone marrow EPCs as well as their levels in circulation (CEPCs). CECs were significantly elevated indicating that endothelial damage occurred due to the exposure. There was no significant difference in EMPs between the two groups. Tube formation and chemotaxis, but not proliferation, of bone marrow EPCs was impaired in the nickel nanoparticle exposed group. These results coincided with a decrease in the mRNA of receptors involved in EPC mobilization and homing. These data provide new insight into how an acute nickel nanoparticle exposure to half of the current Occupational Safety & Health Administration (OSHA) permissible exposure limit may adversely affect EPCs and exacerbate cardiovascular disease states.
DOI: 10.6084/m9.figshare.1577599.v1
title: Brain suppression of AP-1 by inhaled diesel exhaust and reversal by cerium oxide nanoparticles

description: One of the uses of cerium oxide nanoparticles (nanoceria, CeO<sub>2</sub>) is as a diesel fuel additive to improve fuel efficiency. Gene/environment interactions are important determinants in the etiology of age-related disorders. Thus, it is possible that individuals on high-fat diet and genetic predisposition to vascular disease may be more vulnerable to the adverse health effects of particle exposure. The aim of this pilot study was to test the hypothesis that inhalation of diesel exhaust (DE) or diesel exhaust-containing cerium oxide nanoparticles (DCeE) induces stress in the brain of a susceptible animal model. Atherosclerotic prone, apolipoprotein E knockout (ApoE<sup>−/−</sup>) mice fed a high-fat diet, were exposed by inhalation to purified air (control), DE or DCeE. The stress-responsive transcription factor, activator protein-1 (AP-1), was significantly decreased in the cortical and subcortical fraction of the brain after DE exposure. The addition of nanoceria to the diesel fuel reversed this effect. The activation of another stress-related transcription factor (NF-κB) was not inhibited. AP-1 is composed of complexes of the Jun and/or Fos family of proteins. Exposure to DCeE caused c-Jun activation and this may be a mechanism by which addition of nanoceria to the fuel reversed the effect of DE exposure on AP-1 activation. This pilot study demonstrates that exposure to DE does impact the brain and addition of nanoceria may be protective. However, more extensive studies are necessary to determine how DE induced reduction of AP-1 activity and compensation by nanoceria impacts normal function of the brain.
DOI: 10.6084/m9.figshare.1577614.v4
title: MDV files for alaising study

description: Please download from ARM archive
DOI: 10.6084/m9.figshare.1577589
title: In Vito Micropropagation of Orthosiphon aristatus Blume Miq.

description: The study describes and standardises a protocol for the maa propagtion of <em>Orthosiphon aristatus</em> - A rare highly valuable ethnomedicinal herb.
DOI: 10.6084/m9.figshare.1577614.v3
title: MDV files for alaising study

description: Please download from ARM archive
DOI: 10.6084/m9.figshare.1577579
title: Item response theory analysis of the Amyotrophic Lateral Sclerosis Functional Rating Scale-Revised in the Pooled Resource Open-Access ALS Clinical Trials Database

description: Our objective was to examine dimensionality and item-level performance of the Amyotrophic Lateral Sclerosis Functional Rating Scale-Revised (ALSFRS-R) across time using classical and modern test theory approaches. Confirmatory factor analysis (CFA) and Item Response Theory (IRT) analyses were conducted using data from patients with amyotrophic lateral sclerosis (ALS) Pooled Resources Open-Access ALS Clinical Trials (PRO-ACT) database with complete ALSFRS-R data (<i>n</i> = 888) at three time-points (Time 0, Time 1 (6-months), Time 2 (1-year)). Results demonstrated that in this population of 888 patients, mean age was 54.6 years, 64.4% were male, and 93.7% were Caucasian. The CFA supported a 4* individual-domain structure (bulbar, gross motor, fine motor, and respiratory domains). IRT analysis within each domain revealed misfitting items and overlapping item response category thresholds at all time-points, particularly in the gross motor and respiratory domain items. Results indicate that many of the items of the ALSFRS-R may sub-optimally distinguish among varying levels of disability assessed by each domain, particularly in patients with less severe disability. Measure performance improved across time as patient disability severity increased. In conclusion, modifications to select ALSFRS-R items may improve the instrument's specificity to disability level and sensitivity to treatment effects.
DOI: 10.6084/m9.figshare.1577578
title: On the signs of the order parameters

description: Snapshot of blog post from nmrlipids.blogspot.fi done for citing purposes. See link below for properly archieved webpage.
DOI: 10.6084/m9.figshare.1577579.v1
title: Item response theory analysis of the Amyotrophic Lateral Sclerosis Functional Rating Scale-Revised in the Pooled Resource Open-Access ALS Clinical Trials Database

description: Our objective was to examine dimensionality and item-level performance of the Amyotrophic Lateral Sclerosis Functional Rating Scale-Revised (ALSFRS-R) across time using classical and modern test theory approaches. Confirmatory factor analysis (CFA) and Item Response Theory (IRT) analyses were conducted using data from patients with amyotrophic lateral sclerosis (ALS) Pooled Resources Open-Access ALS Clinical Trials (PRO-ACT) database with complete ALSFRS-R data (<i>n</i> = 888) at three time-points (Time 0, Time 1 (6-months), Time 2 (1-year)). Results demonstrated that in this population of 888 patients, mean age was 54.6 years, 64.4% were male, and 93.7% were Caucasian. The CFA supported a 4* individual-domain structure (bulbar, gross motor, fine motor, and respiratory domains). IRT analysis within each domain revealed misfitting items and overlapping item response category thresholds at all time-points, particularly in the gross motor and respiratory domain items. Results indicate that many of the items of the ALSFRS-R may sub-optimally distinguish among varying levels of disability assessed by each domain, particularly in patients with less severe disability. Measure performance improved across time as patient disability severity increased. In conclusion, modifications to select ALSFRS-R items may improve the instrument's specificity to disability level and sensitivity to treatment effects.
DOI: 10.6084/m9.figshare.1577586
title: Long term email communication data within an organization

description: Undirected email correspondence between users of a large organization with over 1,000 individuals for four consecutive years (2007-2010). For this period, we have information of the sender, the receiver and the total amount of emails sent within the organization using the corporate email address. To preserve users' privacy, individuals are completely anonymized and we do not have access to email content (see Ethics statement). The data is in the following format: user1ID user2ID #emails Where #emails is the total amount of emails exchanged (sent and received) in one natural year. The files are separated by years. Ethics statement: This data is exempt from IRB review because: i) The research involves the study of existing data--email logs from 2007 to 2010, which the IT service of the organization archived routinely, as mandated by law; ii) The information is recorded by the investigators in such a manner that subjects cannot be identified, directly or through identifiers linked to the subjects. Indeed, subjects were assigned a "hash" by the IT service prior to the start of our research, so that none of the investigators can link the "hash" back to the subject. We have no demographic information of any kind, so de-anonymization is also impossible.
DOI: 10.6084/m9.figshare.1577577
title: On credits

description: Snapshot of blog post from nmrlipids.blogspot.fi done for citing purposes. See link below for properly archieved webpage.
DOI: 10.6084/m9.figshare.1577578.v2
title: On the signs of the order parameters

description: Snapshot of blog post from nmrlipids.blogspot.fi done for citing purposes. See link below for properly archieved webpage.
DOI: 10.6084/m9.figshare.1577578.v1
title: On the signs of the order parameters

description: Snapshot of blog post from nmrlipids.blogspot.fi done for citing purposes. See http://web.archive.org/web/20150414085027/http://nmrlipids.blogspot.<br>fi/2014/04/on-signs-of-order-parameters.html for properly archieved webpage.
DOI: 10.6084/m9.figshare.1577586.v1
title: Social network email data for long-term dynamics

description: Undirected email correspondence between users of a large organization with over 1,000 individuals for four consecutive years (2007-2010). For this period, we have information of the sender, the receiver and the total amount of emails sent within the organization using the corporate email address. To preserve users' privacy, individuals are completely anonymized and we do not have access to email content (see Ethics statement). The data is in the following format: user1ID user2ID #emails Where #emails is the total amount of emails exchanged (sent and received) in one natural year. The files are separated by years. Ethics statement: This data is exempt from IRB review because: i) The research involves the study of existing data--email logs from 2007 to 2010, which the IT service of the organization archived routinely, as mandated by law; ii) The information is recorded by the investigators in such a manner that subjects cannot be identified, directly or through identifiers linked to the subjects. Indeed, subjects were assigned a "hash" by the IT service prior to the start of our research, so that none of the investigators can link the "hash" back to the subject. We have no demographic information of any kind, so de-anonymization is also impossible.
DOI: 10.6084/m9.figshare.1577577.v2
title: On credits

description: Snapshot of blog post from nmrlipids.blogspot.fi done for citing purposes. See link below for properly archieved webpage.
DOI: 10.6084/m9.figshare.1577576.v2
title: Accuracy of order parameter measurements

description: Snapshot of blog post from nmrlipids.blogspot.fi done for citing purposes. See link below for archived webpage.
DOI: 10.6084/m9.figshare.1577577.v1
title: On credits

description: Snapshot of blog post from nmrlipids.blogspot.fi done for citing purposes. See http://web.archive.org/web/<br>20150414092532/http://nmrlipids.blogspot.fi/2013/07/on-credits.html for properly archieved webpage.
DOI: 10.6084/m9.figshare.1577570
title: Mujer Segura Sustainment

description: The file contains excerpts from interviews conducted with directors and counselors of MexFam affiliated clinics in Mexico participating in an RCT of a psychoeducation intervention designed to prevent HIV and STI in female sex workers
DOI: 10.6084/m9.figshare.1577576.v1
title: Accuracy of order parameter measurements

description: Snapshot of blog post from nmrlipids.blogspot.fi done for citing purposes. See link below for archived webpage.
DOI: 10.6084/m9.figshare.1577569
title: Mark My Bird poster

description: A poster describing the Mark My Bird citizen science/crowd sourcing project.
DOI: 10.6084/m9.figshare.1577565
title: Film and PM Data

description: Narrative transportation is described as a state of detachment that arises when one becomes immersed in the narrative of a story. Participants viewed either an intact version of an engaging 20 min film, “Bang You’re Dead!,” (1961) by Alfred Hitchcock (contiguous condition), or a version of the same film with scenes presented out of order (noncontiguous condition). In this latter condition, the individual scenes were intact but were presented out of chronological order. Participants were told a cover story that we were interested in the amount of gun violence depicted in films. Both groups were given the goal to remember to lift their hand every time they heard the word “gun” spoken during the film. Results revealed that participants were significantly less likely to remember to execute their goal in the contiguous condition, presumably because this narrative transported viewers’ attention and thereby “hijacked” processing resources away from internal goals.
DOI: 10.6084/m9.figshare.1577569.v1
title: Mark My Bird poster

description: A poster describing the Mark My Bird citizen science/crowd sourcing project.