cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.29087171
title: Supplementary Material for: IMMUNE SCENARIO IDENTIFICATION COMBINING MULTIPLEXED, QUANTITATIVE, AND ADVANCED IMAGING ANALYSIS COULD BE RELEVANT IN IMMUNOTHERAPY AGAINST GLIOBLASTOMA AND GRADE 4 ASTROCYTOMA.

description: Introduction
In our research on understanding glioblastoma’s resistance mechanisms to immunotherapy, we extensively investigated through an innovative technology that enables the simultaneous assessment of multiple biomarkers. With this approach, we aim to gain deeper insights into the interplay between immunosuppressive cells (IC) and effector cells (EC).

Methods
It were studied 126 cases of glioblastoma employing tissue microarrays stained with a panel of immune infiltrate validated via multiplex immunofluorescence and quantified by advanced image analysis. All cases were categorized according to an EC/IC ratio and their respective medians. Statistical correlations between cell populations and with survival were calculated.

Results
M2 macrophages were the most abundant IC, followed by a variable number of EC and pro-tumoral activated microglia, and a scant quantity of FoxP3 cells. EC showed a statistically significant direct positive correlation with IC. The patients with tumors exhibiting an EC/IC ratio ≤0.063 displayed a significantly poorer outcome. Furthermore, in the context of incomplete surgical resection, significant differences were evident considering immune scenarios. 



Conclusions
By integrating multiplex technology with advanced imaging analysis, we successfully identified 4 distinct immune scenarios in glioblastoma. We observed a favorable immune scenario characterized by a relatively high EC/IC ratio, which is especially evident in the clinical setting of incomplete tumor resection. This promising immune scenario holds significant potential for selecting suitable candidates for immunotherapy in glioblastoma.
DOI: 10.6084/m9.figshare.29087171.v1
title: Supplementary Material for: IMMUNE SCENARIO IDENTIFICATION COMBINING MULTIPLEXED, QUANTITATIVE, AND ADVANCED IMAGING ANALYSIS COULD BE RELEVANT IN IMMUNOTHERAPY AGAINST GLIOBLASTOMA AND GRADE 4 ASTROCYTOMA.

description: Introduction
In our research on understanding glioblastoma’s resistance mechanisms to immunotherapy, we extensively investigated through an innovative technology that enables the simultaneous assessment of multiple biomarkers. With this approach, we aim to gain deeper insights into the interplay between immunosuppressive cells (IC) and effector cells (EC).

Methods
It were studied 126 cases of glioblastoma employing tissue microarrays stained with a panel of immune infiltrate validated via multiplex immunofluorescence and quantified by advanced image analysis. All cases were categorized according to an EC/IC ratio and their respective medians. Statistical correlations between cell populations and with survival were calculated.

Results
M2 macrophages were the most abundant IC, followed by a variable number of EC and pro-tumoral activated microglia, and a scant quantity of FoxP3 cells. EC showed a statistically significant direct positive correlation with IC. The patients with tumors exhibiting an EC/IC ratio ≤0.063 displayed a significantly poorer outcome. Furthermore, in the context of incomplete surgical resection, significant differences were evident considering immune scenarios. 



Conclusions
By integrating multiplex technology with advanced imaging analysis, we successfully identified 4 distinct immune scenarios in glioblastoma. We observed a favorable immune scenario characterized by a relatively high EC/IC ratio, which is especially evident in the clinical setting of incomplete tumor resection. This promising immune scenario holds significant potential for selecting suitable candidates for immunotherapy in glioblastoma.
DOI: 10.60797/irj.2025.154.17.6
title: Семантические дифференциалы русскоязычных и англоязычных verba educationis

description: Международный научно-исследовательский журнал, Выпуск 4 (154) 2025
DOI: 10.60797/irj.2025.154.17.7
title: Verba educationis с наибольшим числом обратных ассоциаций

description: Международный научно-исследовательский журнал, Выпуск 4 (154) 2025
DOI: 10.60797/irj.2025.154.17.8
title: Verba educationis c наиболее высокой частотностью

description: Международный научно-исследовательский журнал, Выпуск 4 (154) 2025
DOI: 10.60797/irj.2025.154.17.9
title: Verba educationis с развитой деривационной парадигмой

description: Международный научно-исследовательский журнал, Выпуск 4 (154) 2025
DOI: 10.15468/dl.fxbnq4
title: Occurrence Download

description: A dataset containing 160 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Rhododendron camelliiflorum Hook.fil."
 ]
}

 The dataset includes 160 records from 22 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0013116-250415084134356/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.s2gpn8
title: Occurrence Download

description: A dataset containing 24 species occurrences available in GBIF matching the query:
{
 "and" : [
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 "TaxonKey is Limonium cylindrifolium (Forssk.) Verdc. ex Cufod."
 ]
}

 The dataset includes 24 records from 7 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0013117-250415084134356/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.fcqebe
title: Occurrence Download

description: A dataset containing 10 species occurrences available in GBIF matching the query:
{
 "and" : [
 "GadmGid is DEU.3_1",
 "OccurrenceStatus is Present",
 "TaxonKey is Cladonia portentosa (Dufour) Coem."
 ]
}

 The dataset includes 10 records from 3 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0013118-250415084134356/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.wz8mxv
title: Occurrence Download

description: A dataset containing 1191601 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Calamagrostis Adans."
 ]
}

 The dataset includes 1191601 records from 2247 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0013103-250415084134356/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.uubhba
title: Occurrence Download

description: A dataset containing 531965 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Bostrychia hagedash)",
 "HasCoordinate is true",
 "OccurrenceStatus is Present",
 "License is one of (CC-BY 4.0, CC0 1.0)"
 ]
}

 The dataset includes 531965 records from 68 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0083942-250717081556266/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.z7h83c
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "HasGeospatialIssue is false",
 "HasCoordinate is true",
 "OccurrenceStatus is Present",
 "BasisOfRecord is one of (Human Observation, Machine Observation, Occurrence evidence, Observation)",
 "TaxonKey is one of (Turdoides sharpei)",
 "Country is one of (Bermuda, Canada, Greenland, Saint Pierre and Miquelon, United States of America)"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0083972-250717081556266/datasets/export for details.
DOI: 10.15468/dl.zg6scm
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "HasGeospatialIssue is false",
 "HasCoordinate is true",
 "OccurrenceStatus is Present",
 "BasisOfRecord is one of (Human Observation, Machine Observation, Occurrence evidence, Observation)",
 "TaxonKey is one of (Turdoides sharpei)",
 "Country is one of (Afghanistan, Armenia, Azerbaijan, Bahrain, Bangladesh, Bhutan, Brunei Darussalam, Cambodia, China, Cyprus, Georgia, Hong Kong, India, Indonesia, Iran (Islamic Republic of), Iraq, Israel, Japan, Jordan, Kazakhstan, Korea (Democratic People’s Republic of), Korea, Republic of, Kuwait, Kyrgyzstan, Lao People’s Democratic Republic, Lebanon, Macao, Malaysia, Maldives, Mongolia, Myanmar, Nepal, Oman, Pakistan, Palestine, State of, Philippines, Qatar, Saudi Arabia, Singapore, Sri Lanka, Syrian Arab Republic, Tajikistan, Thailand, Timor-Leste, Türkiye, Turkmenistan, United Arab Emirates, Uzbekistan, Viet Nam, Yemen)"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0083971-250717081556266/datasets/export for details.
DOI: 10.15468/dl.2gw6f8
title: Occurrence Download

description: A dataset containing 97 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Brachycope anomala)",
 "HasCoordinate is true",
 "OccurrenceStatus is Present",
 "License is one of (CC-BY 4.0, CC0 1.0)"
 ]
}

 The dataset includes 97 records from 3 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0083974-250717081556266/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.j23gn2
title: Occurrence Download

description: A dataset containing 7 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Glycosmis parviflora",
 "Country is Cuba",
 "HasCoordinate is true"
 ]
}

 The dataset includes 7 records from 4 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0083973-250717081556266/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.3535/30s-zxb-nhp
title: Pilosa Flower, 1883

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/pn9-t9g-3ne
title: Porifera Grant, 1836

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/v7s-v2e-rfq
title: Porifera Grant, 1836

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/xkz-y50-d25
title: Porifera Grant, 1836

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/c9b-p29-abw
title: Animalia

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/8hc-gzx-vbh
title: Chondrichthyes

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/dgs-wtf-7m1
title: Odontaspis

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/lr1-3l7-98k
title: Pseudophillipsia

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/pav-1js-4l6
title: Heteroscleromorpha Cárdenas, Pérez & Boury-Esnault, 2012

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/dqk-9jn-nej
title: Lychniscosida Schrammen, 1903

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/t4j-yre-mv4
title: Heteroscleromorpha Cárdenas, Pérez & Boury-Esnault, 2012

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.15468/dl.8ag8g8
title: Occurrence Download

description: A dataset containing 524 species occurrences available in GBIF matching the query:
{
 "and" : [
 "HasGeospatialIssue is false",
 "HasCoordinate is true",
 "OccurrenceStatus is Present",
 "TaxonKey is Torquigener flavimaculosus",
 {
 "or" : [
 "CoordinateUncertaintyInMeters is less than 5000",
 "CoordinateUncertaintyInMeters is null"
 ]
 }
 ]
}

 The dataset includes 524 records from 20 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0022976-250811113504898/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.3535/bav-xxb-gqm
title: †Caenanoplia Carter, 1968

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/zvf-wzv-1jp
title: Proetus

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/mhc-6ec-tsp
title: Delphinidae Gray, 1821

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/70x-01h-zx1
title: Glyphis

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/czz-pnx-n3n
title: Bos taurus Linnaeus, 1758

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/fwz-bb9-km2
title: Mammalia Linnaeus, 1758

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/ybd-6aw-8xc
title: Delphinapterus leucas (Pallas, 1776)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/5v9-b9c-2p2
title: Animalia

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/nf7-s6c-ng6
title: Rangifer tarandus (Linnaeus, 1758)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/w1a-16t-ysb
title: Mammalia Linnaeus, 1758

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/hgg-13g-dgg
title: Mammalia Linnaeus, 1758

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/tj6-v0y-w5z
title: Bison C. H. Smith, 1827

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/l4y-3nf-ty3
title: †Ptychophylloceras ptychoicum (Quenstedt, 1845)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/x4c-3db-zjp
title: †Trochurus speciosus Beyrich, 1845

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/qkw-r6j-25y
title: †Polytremacis bellardi (Haime, 1852)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/jvb-ews-l7b
title: Bison C. H. Smith, 1827

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/w39-j4z-xml
title: Heteroscleromorpha Cárdenas, Pérez & Boury-Esnault, 2012

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.5517/cc6r1xw
title: CCDC 200908: Experimental Crystal Structure Determination

description: Related Article: K.Kirchner, R.Schmid, K.Mereiter|2003|CSD Communication|||
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.3535/2al-dg0-tl1
title: Mammalia Linnaeus, 1758

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/3y7-9y4-3cq
title: Equus (Equus) caballus Linnaeus, 1758

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/2n7-k3k-a7s
title: Rangifer tarandus (Linnaeus, 1758)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/paa-je5-fvd
title: Odontaspis

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/b7x-6lp-2vg
title: Bos taurus primigenius Bojanus, 1827

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/zg7-r3n-8t0
title: Mammalia Linnaeus, 1758

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/r48-578-6td
title: Bos taurus Linnaeus, 1758

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/26b-avs-6jd
title: Isurus

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/2yh-2hb-5q4
title: Mammalia Linnaeus, 1758

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/0qn-41q-d1f
title: Thurmanniceras

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/pd9-52y-bfl
title: Heteroscleromorpha Cárdenas, Pérez & Boury-Esnault, 2012

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.15468/dl.6bh9aq
title: Occurrence Download

description: A dataset containing 2 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Lokiarchaeia"
 ]
}

 The dataset includes 2 records from 2 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0011154-250426092105405/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.21233/tyqn-ze65
title: Middle Pecos Valley Site P24 vertebrate fauna dataset

description: Raw data for the Middle Pecos Valley Site P24 vertebrate fauna dataset submitted to the Neotoma Paleoecology Database. Data is available through the landing page in JSON format. The landing page referenced by the DOI also contains links to publications and a map-based viewer for the dataset. The Neotoma Paleoecology Database maintains a homepage at https://www.neotomadb.org.
DOI: 10.21233/z50m-k853
title: CRDY30 pollen surface sample dataset

description: Raw data for the CRDY30 pollen surface sample dataset submitted to the Neotoma Paleoecology Database. Data is available through the landing page in JSON format. The landing page referenced by the DOI also contains links to publications and a map-based viewer for the dataset. The Neotoma Paleoecology Database maintains a homepage at https://www.neotomadb.org.
DOI: 10.6084/m9.figshare.28979105
title: 1.2. Questionnaire Response (Underlying Data) - Doomscrolling and Information Overload on Generation Z: Examining the Link Between Excessive Digital Media Consumption and Stress Level

description: Questionnaire response as open data instrument research for research title "Doomscrolling and Information Overload on Generation Z: Examining the Link Between Excessive Digital Media Consumption and Stress Level".
DOI: 10.21233/2kcd-nz81
title: Lörmoos Bern pollen dataset

description: Raw data for the Lörmoos Bern pollen dataset submitted to the Neotoma Paleoecology Database. Data is available through the landing page in JSON format. The landing page referenced by the DOI also contains links to publications and a map-based viewer for the dataset. The Neotoma Paleoecology Database maintains a homepage at https://www.neotomadb.org.
DOI: 10.21233/3p3y-sh40
title: Sliding Slab Rock Shelter [3SB29] vertebrate fauna dataset

description: Raw data for the Sliding Slab Rock Shelter [3SB29] vertebrate fauna dataset submitted to the Neotoma Paleoecology Database. Data is available through the landing page in JSON format. The landing page referenced by the DOI also contains links to publications and a map-based viewer for the dataset. The Neotoma Paleoecology Database maintains a homepage at https://www.neotomadb.org.
DOI: 10.21233/t1b3-dp97
title: Plot1.9_150X150 pollen surface sample dataset

description: Raw data for the Plot1.9_150X150 pollen surface sample dataset submitted to the Neotoma Paleoecology Database. Data is available through the landing page in JSON format. The landing page referenced by the DOI also contains links to publications and a map-based viewer for the dataset. The Neotoma Paleoecology Database maintains a homepage at https://www.neotomadb.org.
DOI: 10.21233/yde9-6124
title: Sams River testate amoebae surface sample dataset

description: Raw data for the Sams River testate amoebae surface sample dataset submitted to the Neotoma Paleoecology Database. Data is available through the landing page in JSON format. The landing page referenced by the DOI also contains links to publications and a map-based viewer for the dataset. The Neotoma Paleoecology Database maintains a homepage at https://www.neotomadb.org.
DOI: 10.21233/1zp3-g555
title: Cranberry Lake diatom bottom sample dataset

description: Raw data for the Cranberry Lake diatom bottom sample dataset submitted to the Neotoma Paleoecology Database. Data is available through the landing page in JSON format. The landing page referenced by the DOI also contains links to publications and a map-based viewer for the dataset. The Neotoma Paleoecology Database maintains a homepage at https://www.neotomadb.org.
DOI: 10.21233/zh9z-cg62
title: Jameson Land insect dataset

description: Raw data for the Jameson Land insect dataset submitted to the Neotoma Paleoecology Database. Data is available through the landing page in JSON format. The landing page referenced by the DOI also contains links to publications and a map-based viewer for the dataset. The Neotoma Paleoecology Database maintains a homepage at https://www.neotomadb.org.
DOI: 10.21233/75kt-vq23
title: La Botica plant macrofossil dataset

description: Raw data for the La Botica plant macrofossil dataset submitted to the Neotoma Paleoecology Database. Data is available through the landing page in JSON format. The landing page referenced by the DOI also contains links to publications and a map-based viewer for the dataset. The Neotoma Paleoecology Database maintains a homepage at https://www.neotomadb.org.
DOI: 10.5517/ccdc.csd.cc2m1njw
title: CCDC 2414668: Experimental Crystal Structure Determination

description: Related Article: Shumi Jia|2025|CSD Communication|||
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2m1nly
title: CCDC 2414670: Experimental Crystal Structure Determination

description: Related Article: Shumi Jia|2025|CSD Communication|||
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2m2vh2
title: CCDC 2415814: Experimental Crystal Structure Determination

description: Related Article: Dongjing Hong|2025|CSD Communication|||
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.