cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.11708169.v1
title: Supplementary Material for: Synergistic Effects of the 308-nm Excimer Light and Topical Calcipotriol for the Treatment of Chronic Hand Eczema: A Randomized Controlled Study

description: <b><i>Background:</i></b> Though topical corticosteroid is a standard treatment for chronic hand eczema (CHE), it can cause many adverse effects. Topical calcipotriol and monochromatic 308-nm excimer light (MEL) are new alternative therapies for several dermatoses, including CHE. <b><i>Objective:</i></b> This study aims to compare the efficacy of the combination of MEL and topical calcipotriol versus topical calcipotriol alone. <b><i>Methods:</i></b> One hand of the participants was randomly assigned to be irradiated with MEL twice weekly and topical calcipotriol applied twice daily while the other hand was assigned to receive only topical calcipotriol twice daily for 8 weeks. Then, only petrolatum ointment was applied during the 4-week follow-up period. Hand Eczema Severity Index (HECSI) and modified Total Lesion Symptom Score were assessed by a blinded investigator, and a visual analogue scale score of itching symptoms was graded by the participants. <b><i>Results:</i></b> In total, 36 hands from 18 subjects completed the protocol. On the combination-treated sides, the mean HECSI score was significantly reduced by 25% (<i>p</i> = 0.015) from the 4th week. Then, it was gradually decreased to 57 and 65% (<i>p</i> &lt; 0.001) at the 8th week and at the follow-up visit, respectively. For the monotherapy-treated sides, the mean HECSI score was reduced to 41% (<i>p</i> = 0.001) and 49% (<i>p</i> &lt; 0.001) at the 8th and 12th week, accordingly. At the end of the treatment period, itching scores were significantly decreased by around 64% (<i>p</i> &lt; 0.001) and 51% (<i>p</i> = 0.002) on the combination-treated and the monotherapy-treated sides. No serious and persistent adverse reactions were found. <b><i>Conclusion:</i></b> The combined MEL and topical calcipotriol may be considered as an alternatively effective treatment for CHE.
DOI: 10.6084/m9.figshare.3563442.v1
title: Appendix A. Sources and pre-processing of environmental data used in the analysis.

description: Sources and pre-processing of environmental data used in the analysis.
DOI: 10.6084/m9.figshare.21866067.v1
title: Supplementary Material for: Challenges and Approach to Identifying Individuals with Salt Sensitivity of Blood Pressure

description: Background: Salt sensitivity of blood pressure (SSBP) is a trait observed in both humans and animals, characterized by an increase in blood pressure (BP) following salt loading or a drop in BP following salt depletion. Summary: This “intermediate” phenotype has been reported in a sizable portion of individuals regardless of their hypertensive status; hypertensives (27-51%), normotensives (18-47%). Further, in epidemiological studies, this phenotype is associated with increased adverse cardiovascular outcomes, risk factors, and reduced survival rates. Here in, we review the challenges in the assessment of SSBP, heterogeneity in the assessment method and protocols, and how these differences could affect the results. Further, we review how to identify individuals with SSBP in the clinic by using clinical and genetic data. No clinical approach has yet provided sufficient sensitivity and specificity to identify those with SSBP. Thus, SSBP is not routinely identified in the clinic. Current genetic data suggest that genotyping may support such an office approach. To date, studies in18 genes have provided sufficient evidence and reproducible data to identify potential mechanisms involved in subsets of subjects with hypertension and SSBP. Key message: Proof-of-concept clinical trials using genetic biomarkers to determine and treat individuals with SSBP are ongoing. Their results will provide critical evidence to support genetic-focused, mechanistically driven algorithms to identify and treat, specifically, individuals with SSBP—personalized medicine.
DOI: 10.5522/04/28507100.v1
title: FTIR PLGA MPs

description: Fourier transform infrared (FTIR) spectroscopy (PerkinElmer Spectrum 100 FT-IR) was also performed to confirm conjugation of antibody to polymeric nanoparticles. The background scan and the sample scan consisted of 8 scan times. A range of antibody concentrations (1μL, 2μL, 4μL) was tested and added before incubation overnight. For this test, the samples were lyophilised, then dispersed on the crystal light path and compressed to obtain respective spectra in the wavelength region of 4000 to 650cm<sup>-1</sup>.<br>The data above are Fourier Transform Infrared (FTIR) spectroscopy data from Poly(lactic-co-glycolic acid) (PLGA) nanoparticles
DOI: 10.6084/m9.figshare.24891573.v2
title: Data from: Improving patient-centred counselling skills among lay healthcare workers in South Africa using the Thusa-Thuso motivational interviewing training and support program

description: We developed a motivational Interviewing (MI) counselling training and support program for lay counsellors in South Africa – branded "Thusa-Thuso - helping you help", commonly referred to as Thusa-Thuso. We conducted a pilot study in South Africa to assess the impact of the Thusa-Thuso program for lay counsellors. We aimed to determine its effect on MI technical skills and explore the feasibility of a training-of-trainers (TOT) scale-up strategy among non-governmental (NGO) partners in the HIV treatment program. Adult (≥ 18 years) lay counsellors from ten primary healthcare clinics in Johannesburg participated in the program, attending the ten-day baseline training and quarterly refresher sessions over 12 months. With lay counsellors' and patients' written informed consent, audio recordings of counselling sessions were collected and reviewed using the MI treatment integrity (MITI) coding system to evaluate technical (cultivating change talk and softening sustain talk) and relational (empathy and partnership) competency scores before and after training. Following 12 months of providing support to pilot training participating lay counsellors, we were requested to expand the training to NGO partner team trainers through a one-time five-day Training of Trainers (TOT) format. This involved 127 trainees from November 2020 to January 2021. We report on the TOT training experiences based on focus group discussions with 42 participants conducted six months after the TOT sessions.
DOI: 10.6084/m9.figshare.25806922.v1
title: Dataset on: Factors Affecting EDRs Use and Impacts in Schools: Does School Principals’ Gender Matter?

description: Dataset on: Factors Affecting EDRs Use and Impacts in Schools: Does School Principals’ Gender Matter?<br>
DOI: 10.6084/m9.figshare.26964226.v1
title: Fine-tuning set organic chemistry synthetic procedures for AI

description: Fine-tuning set organic chemistry synthetic procedures for gpt-4o-mini-2024-07-18. 31 records. Taken from USPTO dataset 2024 and sampled from academic literature 2024. Objective: scrape relevant information for reactants, reagents, solvents and product. Filetype: jsonl.Trained tokens 61.065Epochs 3 Batch size 1 raining loss 0.0258LR multiplier 1.8
DOI: 10.6084/m9.figshare.28826609.v1
title: Figure 1 PDCT data

description: Pole descent cliff task data.
DOI: 10.6084/m9.figshare.14672016.v1
title: cdg2013

description: GWAS summary statistics from the Psychiatric Genomics Consortium (PGC)
DOI: 10.6084/m9.figshare.28765613.v1
title: Optical multi-beam steering and communication using integrated acousto-optics arrays

description: Source data and processing code for plotting figures for paper entitled "Optical multi-beam steering and communication using integrated acousto-optics arrays"
DOI: 10.6084/m9.figshare.28702220.v1
title: ICMLRebuttal.pdf

description: ICML Rebuttal
DOI: 10.6084/m9.figshare.6604763.v1
title: The ergosterol X-ray data

description: The ergosterol X-ray data
DOI: 10.6084/m9.figshare.12627140.v1
title: MODFLOW-OWHM_v2_Across_the_US

description: Modeling the Surface Water and Groundwater Budgets of the US using MODFLOW-OWHM
DOI: 10.6084/m9.figshare.20152538.v1
title: Flow Cytomerty

description: Flow Cytomerty of DHA
DOI: 10.15468/dl.qwuqce
title: Occurrence Download

description: A dataset containing 33167 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is one of (Brazil, Peru)",
 "OccurrenceStatus is Present",
 "TaxonKey is Astyanax Baird & Girard, 1854"
 ]
}

 The dataset includes 33167 records from 91 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0009624-250426092105405/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.6084/m9.figshare.13548017.v1
title: Data_empírico1e2

description: Data from a comparative study with different teaching approaches
DOI: 10.6084/m9.figshare.6249428.v1
title: RAAAP CurrentEmploymentStatusDetails

description: The RAAAP project surveyed Research Managers and Administrators from across the world, asking questions about why people became RMAs, why they stayed as RMAs, what skills they need for their jobs (soft and hard), what level of seniority they are, demographic information, and so on - overall up to 222 data points were collected from each respondent. This subsidiary dataset contains (anonymised) free text responses about the current employment of respondents. Note that to promote anonymity responses are only linked to the main dataset by AnalysisRegionOfEmployment
DOI: 10.6084/m9.figshare.1407004.v1
title: Datasets

description: Contains all the datasets available in the TISSUES database with all the data, including the non-confident gene-tissue associations. The non-confident associations are not available at the TISSUES database but were used in the fold enrichment analyses. The files format is: Taxon_id ENSP tissues_code BTO source evidences confidence_score(stars) linkout
DOI: 10.6084/m9.figshare.24261385.v6
title: Lili-Mip trajectories and results.zip

description: The unique viviparous Pacific Beetle cockroaches provide nutrition to their embryo by secreting milk proteins Lili-Mip, which is a lipid-binding glycoprotein that crystallizes in-vivo. The resolved in-vivo crystal structure of variably glycosylated Lili-Mip shows a classical Lipocalin fold with an eight-stranded antiparallel beta-barrel enclosing a<br>fatty acid. The availability of physiologically unaltered glycoprotein structure makes Lili-Mip a very attractive model system to investigate the role of glycans on protein structure, dynamics, and function. Towards that end, we have employed all-atom molecular dynamics simulations on various glycosylated stages of a bound and free Lili-Mip protein and characterized the impact of glycans and the bound lipid on the dynamics of this glycoconjugate.<br>Our work provides important molecular-level mechanistic insights into the role of glycans in the nutrient storage function of the Lili-Mip protein. Our analyses show that the glycans stabilize spatially proximal residues and regulate the low amplitude opening motions of the residues at the entrance of the binding pocket. Glycans also preserve the native orientation and conformational flexibility of ligand. However, we find that extreme glycosylation with highly complex glycans or deglycosylation affects the conformation and dynamics noticeably. A simple but effective distance- and correlation-based network analyses of the protein also reveal the key residues regulating the architecture and ligand binding characteristics of the barrel in response to glycosylation.
DOI: 10.6084/m9.figshare.24757683.v1
title: ACON

description: Full name: ACON SARS-CoV-2 IgG/IgM Antibody Test (abbr: ACON_Ab)organization: raw images, cropped membranes, config: label & cropping dimension<br>
DOI: 10.6084/m9.figshare.28341992.v2
title: Process Mining in CeLOE

description: Student activities in Learning Management System
DOI: 10.6084/m9.figshare.13382969.v1
title: Data from "Ecological diversity within rear-edge: a case study from Mediterranean Quercus pyrenaica Willd. forests"

description: Data used for the manuscript: <br> "Ecological diversity within rear-edge: a case study from Mediterranean Quercus pyrenaica Willd. forests"<br><br>Datasets: - table1_oak_populations.csv contains information about the oak woodland populations in Sierra Nevada- table2_dicc_variables.csv contains a description of the variables used in the analysis. - table_suplementary_1.csv contains the list of the species presents in each population. - species_code.csv contains the codes used for each species<br>The datafiles environmental_matrix.csv, forest_attribute_matrix.csv, forest_environmental_matrix.csv and species_composition_matrix.csv are the data used for the anlayusis. See Figure 2 in the manuscript (also included in this dataset). <br><br>
DOI: 10.6084/m9.figshare.14207984.v1
title: CM1 Namelist

description: CM1 namelist<br>
DOI: 10.6084/m9.figshare.16778557.v2
title: Childhood malnutrition and Hypomineralized molar defects , a cross sectional study.

description: Data of cross sectional study entitled <b>Childhood malnutrition and Hypomineralized molar defects , a cross sectional study.<br></b><b> </b>
DOI: 10.6084/m9.figshare.24916161.v1
title: Supplementary Material for: Genetics of retinitis pigmentosa and other hereditary retinal disorders in Western Switzerland

description: Abstract
Introduction: Mutational screening of inherited retinal disorders is prerequisite for gene targeted therapy. Our aim is to report and analyze the proportions of mutations in inherited retinal disease (IRD) causing genes from a single center in Switzerland in order to describe the distribution of IRDs in Western Switzerland.
Methods: We conducted a retrospective study of patient records. Criteria for inclusion were residence in Western Switzerland for patients and relatives presenting a clinical diagnosis of IRDs and an established molecular diagnosis managed by the genetics service of the Jules-Gonin Eye Hospital (JGEH) of Lausanne between January 2002 and December 2022. We initially investigated the IRD phenotypes in all patients (full cohort) with a clinical diagnosis, then calculated the distribution of IRD gene mutations in the entire cohort (genetically determined cohort). We analyzed a sub-group that comprised pediatric patients (≤ 18 years of age). In addition, we calculated the distribution of gene mutations within the most represented IRDs. Comprehensive gene screening was performed using a combined approach of different generation of DNA microarray analysis, direct sequencing and Sanger sequencing.
Results: The full cohort comprised 899 individuals from 690 families with a clinical diagnosis of IRDs. We identified 400 individuals from 285 families with an elucidated molecular diagnosis (variants in 84 genes) in the genetically determined cohort. The pediatric cohort included 89 individuals from 65 families with an elucidated molecular diagnosis. The molecular diagnosis rate for the genetically determined cohort was 58.2 % (family ratio) and the 5 most frequently implicated genes per family were ABCA4 (11.6 %), USH2A (7.4 %), EYS (6.7 %), PRPH2 (6.3 %) and BEST1 (4.6 %). The pediatric cohort had a family molecular diagnosis rate of 64.4 % and the 5 most common mutated genes per family were RS1 (9.2 %), ABCA4 (7.7 %), CNGB3 (7.7 %), CACNA1F (6.2 %), CEP290 (4.6 %). 
Conclusions: This study describes the genetic mutation landscape of IRDs in Western Switzerland in order to quantify their disease burden and contribute to a better orientation of the development of future gene targeted therapies.
DOI: 10.6084/m9.figshare.21878426.v1
title: pancreas.h5ad

description: Pancreas data for demo of scPoli
DOI: 10.6084/m9.figshare.19710655.v1
title: Supplementary Material for: The Role of Uremic Retention Solutes in the MIA Syndrome in Hemodialysis Subjects

description: <b><i>Introduction:</i></b> In chronic kidney disease (CKD), the high morbidity and mortality risk for cardiovascular disease (CVD) are not easily explained only on the basis of traditional factors. Among nontraditional ones involved in CKD, malnutrition, inflammation, and atherosclerosis/calcification have been described as the “MIA syndrome.” <b><i>Methods:</i></b> In this pilot study, we evaluated the association between the variation in serum levels of 27 uremic retention solutes plus 6 indexes related to the MIA syndrome processes in a population of dialysis patients. <b><i>Results:</i></b> As expected, we found a direct correlation between serum albumin and both phosphate and total cholesterol (<i>r</i> = 0.54 and 0.37, respectively; <i>p</i> &lt; 0.05). Moreover, total cholesterol and phosphate directly correlate (<i>r</i> = 0.40, <i>p</i> &lt; 0.05). The relationship between malnutrition and inflammation is highlighted by the correlation of serum cholesterol levels with serum alpha-1 acid glycoprotein and IL-6 levels (<i>r</i> = −0.56, <i>r</i> = −0.39, respectively; <i>p</i> &lt; 0.05). Moreover, the relation between inflammation and atherosclerosis/calcification is supported by the correlation of IL-6 with VEGF levels and vascular smooth muscle cell high-Pi in vitro calcification (<i>r</i> = 0.81, <i>r</i> = 0.66, respectively; <i>p</i> &lt; 0.01). <b><i>Conclusion:</i></b> We found significant correlations between several uremic retention solutes and malnutrition, inflammation, and atherosclerosis/calcification. Our findings support the hypothesis of a central role of the <i>uremic milieu</i> in the MIA syndrome and ultimately in the pathogenesis of CKD-specific CVD risk factors.
DOI: 10.6084/m9.figshare.1243747.v1
title: SPSS Data File of the Study

description: This is the raw data file with which the analysis of the paper entitled ' Gratefully received, gratefully repaid: the role of perceived fairness in cooperative interactions' was carried out. Please refer to the dataset explanatory document (http://figshare.com/articles/Explanatory_Document_for_the_SPSS_Data_File_of_the_Study/1243735) for details.
DOI: 10.6084/m9.figshare.5127160.v1
title: Supplementary Material for: Administration of Umbilical Cord Blood Cells Transiently Decreased Hypoxic-Ischemic Brain Injury in Neonatal Rats

description: This study aimed to investigate whether the administration of mononuclear cells derived from human umbilical cord blood cells (UCBCs) could ameliorate hypoxic-ischemic brain injury in a neonatal rat model. The left carotid arteries of 7-day-old rats were ligated, and the rats were then exposed to 8% oxygen for 60 min. Mononuclear cells derived from UCBCs using the Ficoll-Hypaque technique were injected intraperitoneally 6 h after the insult (1.0 × 10<sup>7</sup> cells). Twenty-four hours after the insult, the number of cells positive for the oxidative stress markers 4-hydroxy-2-nonenal and nitrotyrosine, in the dentate gyrus of the hippocampus in the UCBC-treated group, decreased by 36 and 42%, respectively, compared with those in the control group. In addition, the number of cells positive for the apoptosis markers active caspase-3 and apoptosis-inducing factor decreased by 53 and 58%, respectively. The number of activated microglia (ED1-positive cells) was 51% lower in the UCBC group compared with the control group. In a gait analysis performed 2 weeks after the insult, there were no significant differences among the sham-operated, control and UCBC groups. An active avoidance test using a shuttle box the following week also revealed no significant differences among the groups. Neither the volumes of the hippocampi, corpus callosum and cortices nor the numbers of neurons in the hippocampus were different between the UCBC and control groups. In summary, a single intraperitoneal injection of UCBC-derived mononuclear cells 6 h after an ischemic insult was associated with a transient reduction in numbers of apoptosis and oxidative stress marker-positive cells, but it did not induce long-term morphological or functional protection. Repeated administration or a combination treatment may be required to achieve sustained protection.
DOI: 10.6084/m9.figshare.1334271.v1
title: Finnish Effort Estimation Dataset

description: The column identifiers are as follows: Project_tech_ID = Project code<br>YK = Customer code<br>Project_name = Project identifier<br>Business_names = Business sector of the customer<br>Protype_names = Development type<br>Hardware_names = Hardware/platform type<br>Duration = Duration of the project in months<br>Size_ep99_proj = Total size of the project software in Experience 2.0 FP's<br>Worksup = Total effort of the supplier<br>SituCoeff = Situation coefficient multiplier<br>T01 = Involvement of the customer representatives<br>T02 = Performance and availability of the development environment<br>T03 = Availability of IT staff<br>T04 = Number of stakeholders<br>T05 = Pressure on schedule<br>T06 = Impact of standards<br>T07 = Impact of methods<br>T08 = Impact of tools<br>T09 = Level of change management<br>T10 = Maturity of software development process<br>T11 = Logical complexity of software<br>T12 = Size of database based on number of entities<br>T13 = Number of interfaces to other software<br>T14 = Quality requirements of software<br>T15 = Efficiency requirements of software<br>T16 = Training and installation/platform requirements<br>T17 = Analysis skills of staff<br>T18 = Application knowledge of staff<br>T19 = Tool skills of staff<br>T20 = Experience of project management<br>T21 = Team skills of the project team<br>InpTot = Total number of input functions<br>InpFP = Size of inputs in Experience 2.0 fp's<br>InqTot = Total number of inquiry functions<br>InqFP = Size of inquiries in Experience 2.0 fp's<br>OutTot = Total number of output functions<br>OutFP = Size of outputs in Experience 2.0 fp's<br>IntTot = Total number of interface functions<br>IntFP = Size of interfaces in Experience 2.0 fp's<br>EntTot = Total number of entities<br>EntFP = Size of entities in Experience 2.0 fp's<br>AlgTot = Total number of algorithmic functions<br>AlgFP = Size of algorithms in Experience 2.0 fp's<br>AllTot = Total number of all types of functions<br>AllFP_ep20 = Application size in Experience 2.0 fp's
DOI: 10.6084/m9.figshare.7941584.v1
title: Lymphoma in leukemic phase in feline coinfected with feline immunodeficiency virus and feline leukemia virus: case report

description: ABSTRACT The present study aimed to report a case of lymphoma in leukemic phase in feline coinfected with feline immunodeficiency virus (FIV) and feline leukemia virus (FeLV). Blood counts, reticulocyte counts, bone marrow avaluation, biochemistry, immunochromatography assay for FIV and FeLV, indirect immunofluorescence (IFA) for FeLV, thoracic radiography and renal citology were performed. This last examination revealed extranodal lymphoma. The association of the clinical signs with the infiltration of a high number of lymphoblastic cells in the bone marrow with cytomorphological criteria of malignancy, atypical mitoses, lymphoglandular corpuscles and hematopoietic material were determinant for the diagnostic conclusion. Lymphoma is a relatively common neoplasm in felines, however the leukemic phase is rare and may represent a clinical diagnostic challenge, making it essential to include bone marrow cytology in the clinical practice of this species.