cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.5241631
title: Erratum: Culture Qualitatively but Not Quantitatively Influences Performance in the Boston Naming Test in a Chinese-Speaking Population

description: <b><i>Background/Aims:</i></b> The Boston Naming Test (BNT) is the most frequently administered confrontational naming test, but the cultural background of the patients may influence their performance in the BNT. The aim of this study was to identify differences in performance in the BNT between a Chinese population in Taiwan, Chinese populations in other areas and a Caucasian population. <b><i>Methods:</i></b> A total of 264 native, Chinese-speaking, cognitively normal elders aged &gt;60 years were enrolled in our study and conducted the 30-item Chinese version of the BNT. Another 10 BNT studies were categorized, analyzed and compared with the present study. <b><i>Results:</i></b> Higher education was associated with higher scores, whereas age and gender had no effect on performance in the BNT. The score of the Chinese-speaking population was equivalent to the English-speaking population. A disparity in difficulties with items was not only apparent between the Taiwanese and Caucasian populations, but also between the Chinese-speaking populations in the different geographic areas. <b><i>Conclusion:</i></b> For the most part, the impact of culture on performance in the BNT may not be quantitative but qualitative. Attention should be paid to a potential effect of culture on difficulties with items when administering the BNT to non-English-speaking populations. Understanding differences in performance in the BNT in distinct cultural settings improves the clinical application of the BNT.
DOI: 10.6084/m9.figshare.5241625
title: Erratum: <b><i>THADA</i></b> Gene Polymorphism and Prostate Cancer Risk: A Meta-Analysis

description: <b><i>Background: </i></b>The single nucleotide polymorphism (SNP) rs1465618 in <i>THADA</i> at 2p21 has been identified as being associated with prostate cancer (PCa) risk in Europeans; however, it is not clear whether the SNP is related to PCa risk in multiple populations. We investigated the association of rs1465618 in <i>THADA</i> with PCa in a Chinese population and carried out a meta-analysis in multiple populations, testing the relevance of this SNP for PCa risk. <b><i>Patients and Methods: </i></b>We genotyped the SNP using high resolution melting (HRM) analysis and assessed its association with PCa risk in a case-control study of 289 PCa patients and 288 controls in a Chinese population. A meta-analysis was carried out with 36,313 PCa patients and 36,485 controls to evaluate the association of rs1465618 with PCa risk in multiple populations. <b><i>Results: </i></b>rs1465618 in <i>THADA</i> was significantly associated with PCa risk (p = 0.026; odds ratio (OR) 1.327, 95% confidence interval (CI) 1.035-1.700). Furthermore, the rs1465618 variant genotype was associated with PCa aggressiveness (p = 0.044; OR = 2.053, 95% CI = 1.015-6.602) in the Chinese population. The meta-analysis showed that rs1465618 was significantly associated with PCa risk in multiple populations (p = 1.0×10<sup>-8</sup>; OR = 1.127, 95% CI = 1.085-1.171). <b><i>Conclusion: </i></b>Our results showed that rs1465618 in <i>THADA</i> may be a shared susceptibility variant for PCa in multiple populations. <i>THADA</i> gene polymorphisms may impact PCa susceptibility and progression.
DOI: 10.6084/m9.figshare.5241652.v1
title: Erratum: Solar Elastosis in Its Papular Form: Uncommon, Mistakable

description: Solar elastosis is a degenerative condition of elastic tissue in the dermis due to prolonged sun exposure. There are a variety of clinical manifestations of solar elastosis. In its most common form, solar elastosis manifests as yellow, thickened, coarsely wrinkled skin. We report two uncommon cases of severe solar elastosis with a papular morphology. Its presentation can closely mimic a host of cutaneous disorders and thus, although it is helpful to be cognizant of this entity, it is still crucial to biopsy these lesions to avoid missing a more sinister condition.
DOI: 10.6084/m9.figshare.5241628.v1
title: Erratum: Clinical and Radiological Features in CADASIL and <b><i>NOTCH3</i></b>-Negative Patients: A Multicenter Study from Turkey

description: <b><i>Background:</i></b> The diversity of clinical presentation and neuroimaging findings of CADASIL (cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy) from different regions of the world has not yet been studied in depth. Here we investigated the variability of clinical, radiological and genetic data of 48 patients analyzed for <i>NOTCH3</i> mutation in Turkey. <b><i>Methods:</i></b> Clinical evaluation was made according to a preformed questionnaire. Cranial neuroimaging findings were determined on the basis of T1, T2, FLAIR and proton-density magnetic resonance scans. For genetic analysis, polymerase chain reaction was performed with primers flanking exons 2-6 and 11 of <i>NOTCH3 </i>gene. <b><i>Results:</i></b> Twenty-five patients (52.1%) were diagnosed as CADASIL with <i>NOTCH3</i> mutation, while 23 patients (47.9%) had no mutation (<i>NOTCH3</i>-negative patients). The mean age and age at stroke onset were lower in male CADASIL patients (p &lt; 0.03). A family history of migraine (p = 0.012), stroke (p &lt; 0.001), recurrent strokes (p = 0.020) and dementia (p = 0.012) was more common in CADASIL patients. Temporal pole involvement was more common in CADASIL patients (p = 0.004). <b><i>Conclusion:</i></b> It is of clinical importance to identify the heterogeneity of CADASIL from different countries due to a low correlation of clinical and radiological data with respect to <i>NOTCH3</i> mutation.
DOI: 10.6084/m9.figshare.5241613
title: Erratum: 2013 Statement on Human Papillomavirus DNA Test Utilization

description: This statement from the Cytopathology Education and Technology Consortium summarizes appropriate and inappropriate uses of human papillomavirus testing in cervical cancer screening based on guidelines from the American Society for Colposcopy and Cervical Pathology and the American Cancer Society.
DOI: 10.6084/m9.figshare.5241619
title: Erratum: Pyrosequencing Evaluation of Widely Available Bisulfite Conversion Methods: Considerations for Application

description: <b><i>Introduction:</i></b> Bisulfite treatment of DNA introduces methylation-dependent sequence changes through selective chemical conversion of nonmethylated cytosine to uracil and serves as pretreatment step for the majority of DNA methylation analysis methods. <b><i>Methods:</i></b> We have evaluated the conversion performance of five of the most commonly used bisulfite treatment kits [MethylDetector (Active Motif), Epitect+ (Qiagen), Zymo Methylation, Zymo Gold and Zymo Lightning (all from Zymo Research)] by pyrosequencing four different regions with variable methylation levels, including: a repetitive element <i>(ALUSX)</i>, a gene with low levels of methylation <i>(IL6ST)</i>, an imprinted gene expected to be approximately 50% methylated <i>(IGF2)</i>, and a fully methylated gene <i>(ST3GAL2)</i>. In addition, we have studied the influence of duration (3 vs. 16 h) and type (fixed temperature vs. cycling program) of incubation protocol on the conversion efficiency of each evaluated kit. <b><i>Results:</i></b> All kits produced similar conversion rates of <i>ALUSX,</i><i>IGF2</i> and <i>ST3GAL2</i>, while the conversion of the low methylated <i>IL6ST</i> gene was variable between kits. The Zymo kits were highly consistent in their performance even when different protocols of incubation were applied, generating full conversion at the low methylated gene <i>IL6</i>; this was not true for the MethylDetector and Epitect+ kits. However, long-cycling incubation could produce similar conversion rates for the same locus in combination with Active Motif and Qiagen kits. <b><i>Conclusions:</i></b> The selection of a long-cycling protocol during conversion permits standardization of protocols, improving the reproducibility of methylation estimates across laboratories for gene-specific, genome-wide and bisulfite-based sequencing analyses.
DOI: 10.6084/m9.figshare.5241625.v1
title: Erratum: <b><i>THADA</i></b> Gene Polymorphism and Prostate Cancer Risk: A Meta-Analysis

description: <b><i>Background: </i></b>The single nucleotide polymorphism (SNP) rs1465618 in <i>THADA</i> at 2p21 has been identified as being associated with prostate cancer (PCa) risk in Europeans; however, it is not clear whether the SNP is related to PCa risk in multiple populations. We investigated the association of rs1465618 in <i>THADA</i> with PCa in a Chinese population and carried out a meta-analysis in multiple populations, testing the relevance of this SNP for PCa risk. <b><i>Patients and Methods: </i></b>We genotyped the SNP using high resolution melting (HRM) analysis and assessed its association with PCa risk in a case-control study of 289 PCa patients and 288 controls in a Chinese population. A meta-analysis was carried out with 36,313 PCa patients and 36,485 controls to evaluate the association of rs1465618 with PCa risk in multiple populations. <b><i>Results: </i></b>rs1465618 in <i>THADA</i> was significantly associated with PCa risk (p = 0.026; odds ratio (OR) 1.327, 95% confidence interval (CI) 1.035-1.700). Furthermore, the rs1465618 variant genotype was associated with PCa aggressiveness (p = 0.044; OR = 2.053, 95% CI = 1.015-6.602) in the Chinese population. The meta-analysis showed that rs1465618 was significantly associated with PCa risk in multiple populations (p = 1.0×10<sup>-8</sup>; OR = 1.127, 95% CI = 1.085-1.171). <b><i>Conclusion: </i></b>Our results showed that rs1465618 in <i>THADA</i> may be a shared susceptibility variant for PCa in multiple populations. <i>THADA</i> gene polymorphisms may impact PCa susceptibility and progression.
DOI: 10.6084/m9.figshare.5241631.v1
title: Erratum: Culture Qualitatively but Not Quantitatively Influences Performance in the Boston Naming Test in a Chinese-Speaking Population

description: <b><i>Background/Aims:</i></b> The Boston Naming Test (BNT) is the most frequently administered confrontational naming test, but the cultural background of the patients may influence their performance in the BNT. The aim of this study was to identify differences in performance in the BNT between a Chinese population in Taiwan, Chinese populations in other areas and a Caucasian population. <b><i>Methods:</i></b> A total of 264 native, Chinese-speaking, cognitively normal elders aged &gt;60 years were enrolled in our study and conducted the 30-item Chinese version of the BNT. Another 10 BNT studies were categorized, analyzed and compared with the present study. <b><i>Results:</i></b> Higher education was associated with higher scores, whereas age and gender had no effect on performance in the BNT. The score of the Chinese-speaking population was equivalent to the English-speaking population. A disparity in difficulties with items was not only apparent between the Taiwanese and Caucasian populations, but also between the Chinese-speaking populations in the different geographic areas. <b><i>Conclusion:</i></b> For the most part, the impact of culture on performance in the BNT may not be quantitative but qualitative. Attention should be paid to a potential effect of culture on difficulties with items when administering the BNT to non-English-speaking populations. Understanding differences in performance in the BNT in distinct cultural settings improves the clinical application of the BNT.
DOI: 10.6084/m9.figshare.5241607
title: Erratum: Biventricular Pacing Cardiac Contractility Modulation Improves Cardiac Contractile Function via Upregulating SERCA2 and miR-133 in a Rabbit Model of Congestive Heart Failure

description: <b><i>Objective: </i></b>To compare the effects of biventricular electrical pacing and conventional single-ventricular pacing for cardiac contractility modulation (CCM) on cardiac contractile function and to delineate the underlying molecular mechanisms. <b><i>Methods</i></b><b><i>: </i></b>Forty rabbits were divided into four groups before surgery: healthy control, HF sham, HF left ventricular pacing CCM (LVP-CCM), and HF biventricular pacing CCM (BVP-CCM) groups with n=10 for each group. A rabbit model of chronic heart failure was established by ligating ascending aortic root of rabbits. Then electrical stimulations during the absolute refractory period were delivered to the anterior wall of left ventricle in the LVP-CCM group and on the anterior wall of both left and right ventricles in the BVP-CCM group lasting six hours per day for seven days. Changes in ventricular structure, cardiac function and electrocardiogram were monitored before and after CCM stimulation. <b><i>Results: </i></b>Compared with the sham-operated group, heart weight, heart weight index, LV end-systolic diameter (LVESD), LV end-diastolic diameter (LVEDD) in the LVP-CCM and BVP-CCM groups were significantly decreased (<i>p</i>&lt;0.05), while LV ejection fraction (LVEF) and fractional shortening fraction (FS) were increased (<i>p</i>&lt;0.05). Notably all these changes were consistently found to be greater in BVP-CCM than in LVP-CCM. Moreover, plasma BNP levels were highest in the HF sham-control group, followed by the LVP-CCM group, and lowest in the BVP-CCM group (<i>p</i>&lt;0.05). Furthermore, sarco/endoplasmic reticulum Ca<sup>2+</sup>-ATPase (SERCA2a) protein levels were upregulated by 1.7 and 2.4 fold, along with simultaneous upregulation of a cardiac-enriched microRNA miR-133 levels by 2.6 and 3.3 fold, in LVP-CCM and BVP-CCM, respectively, compared to sham. <b><i>Conclusions: </i></b>Biventricular pacing CCM is superior to conventional monoventricular pacing CCM, producing greater improvement cardiac contractile function. Greater upregulation of SERCA2 and miR-133 may account, at least partially, for the improvement by BVP-CCM.
DOI: 10.6084/m9.figshare.5241610
title: Erratum: Celecoxib Enhances Radiosensitivity via Induction of G<sub>2</sub>-M Phase Arrest and Apoptosis in Nasopharyngeal Carcinoma

description: <b><i>Background: </i></b>Previous work has proposed that celecoxib may be able to enhance the effects of radiotherapy. However, the underlying mechanism of this activity has not yet been determined. <b><i>Methods: </i></b>The cell colony formation assay after the combination of celecoxib and radiation treatment was done on C666-1, CNE-1 and CNE-2 nasopharyngeal carcinoma cells, which expressed different COX-2 levels. Moreover, COX-2 knocked down or overexpressed cells were developed, and apoptosis and cell cycle analysis were performed. <b><i>Results: </i></b>Celecoxib enhances radiation cytotoxicity in C666-1 and CNE-1 nasopharyngeal carcinoma cells that expressed high COX-2 but not in CNE-2 cells that expressed low COX-2. The radiosensitization of celecoxib in C666-1 cells disappeared after the COX-2 knocked down, while the CNE-2 cells were radiosensitized by celecoxib after the transfection of COX-2. Moreover, celecoxib enhanced radiation-induced G<sub>2</sub>-M phase arrest was observed in some of the tested cells. Furthermore, we found that the radiosensitivity of celecoxib in nasopharyngeal carcinoma was correlated with the apoptosis induction. Additionally, the combination of celecoxib (25 mg/kg) and radiation (6 Gy) treatment significantly reduced tumor volume in C666-1 and CNE-2 nasopharyngeal carcinoma xenograft models. <b><i>Conclusion: </i></b>These results indicate that the combination of celecoxib and radiation treatment has potential application in radiotherapy, and these effects may be attributable to the G<sub>2</sub>-M cell phase arrest and enhancement of cell apoptosis. © 2014 S. Karger AG, Basel
DOI: 10.6084/m9.figshare.5241613.v1
title: Erratum: 2013 Statement on Human Papillomavirus DNA Test Utilization

description: This statement from the Cytopathology Education and Technology Consortium summarizes appropriate and inappropriate uses of human papillomavirus testing in cervical cancer screening based on guidelines from the American Society for Colposcopy and Cervical Pathology and the American Cancer Society.
DOI: 10.6084/m9.figshare.5241619.v1
title: Erratum: Pyrosequencing Evaluation of Widely Available Bisulfite Conversion Methods: Considerations for Application

description: <b><i>Introduction:</i></b> Bisulfite treatment of DNA introduces methylation-dependent sequence changes through selective chemical conversion of nonmethylated cytosine to uracil and serves as pretreatment step for the majority of DNA methylation analysis methods. <b><i>Methods:</i></b> We have evaluated the conversion performance of five of the most commonly used bisulfite treatment kits [MethylDetector (Active Motif), Epitect+ (Qiagen), Zymo Methylation, Zymo Gold and Zymo Lightning (all from Zymo Research)] by pyrosequencing four different regions with variable methylation levels, including: a repetitive element <i>(ALUSX)</i>, a gene with low levels of methylation <i>(IL6ST)</i>, an imprinted gene expected to be approximately 50% methylated <i>(IGF2)</i>, and a fully methylated gene <i>(ST3GAL2)</i>. In addition, we have studied the influence of duration (3 vs. 16 h) and type (fixed temperature vs. cycling program) of incubation protocol on the conversion efficiency of each evaluated kit. <b><i>Results:</i></b> All kits produced similar conversion rates of <i>ALUSX,</i><i>IGF2</i> and <i>ST3GAL2</i>, while the conversion of the low methylated <i>IL6ST</i> gene was variable between kits. The Zymo kits were highly consistent in their performance even when different protocols of incubation were applied, generating full conversion at the low methylated gene <i>IL6</i>; this was not true for the MethylDetector and Epitect+ kits. However, long-cycling incubation could produce similar conversion rates for the same locus in combination with Active Motif and Qiagen kits. <b><i>Conclusions:</i></b> The selection of a long-cycling protocol during conversion permits standardization of protocols, improving the reproducibility of methylation estimates across laboratories for gene-specific, genome-wide and bisulfite-based sequencing analyses.
DOI: 10.6084/m9.figshare.5241598
title: Erratum: Preoperative Scoring and Limits of Prognostication: Functional Outcome after Surgical Decompression in Metastatic Spinal Cord Compression

description: <b><i>Objective:</i></b> To determine whether preoperative parameters correlate with the postoperative functional outcome in para- and tetraplegic patients with lung, kidney, breast and prostate cancer and metastatic spinal cord compression (MSCC). <b><i>Methods:</i></b> Information on 43 patients undergoing decompressive surgery and rehabilitation for MSCC was reviewed, including primary tumor, age, pre- and postoperative ambulation status, mobility subcategory of the Spinal Cord Injury Measure (mSCIM) and the Tokuhashi score. Differences between groups were analyzed by the nonparametric χ<sup>2</sup> test, and correlation coefficients (Spearman's rho) were computed. <b><i>Results:</i></b> Preoperative ambulation (p &lt; 0.001), the American Spinal Injury Association Impairment Scale (p &lt; 0.001) and the type of operation (p = 0.02) influenced the postoperative functional outcome. Any positive change in the mSCIM was influenced by preoperative ambulation (p &lt; 0.001). Patients with breast carcinoma showed significantly more positive changes in the mSCIM compared with other tumors (p = 0.002). No correlation was found between the treatment categories of the Tokuhashi score and the preoperative ambulatory status (p = 0.13) or the change in ambulation status (p = 0.29). <b><i>Conclusion:</i></b> The postoperative functional outcome of MSCC patients shows a linear association between the categories of the Tokuhashi score and the change in ambulation status. We recommend surgical decompression even in a palliative situation (Tokuhashi score 0-8) with the aim of optimizing the short-term rehabilitation outcome. © 2014 S. Karger AG, Basel
DOI: 10.6084/m9.figshare.5241604
title: Erratum: Estradiol Modulates the Expression Pattern of Myosin Heavy Chain Subtypes via an ERα-Mediated Pathway in Muscle-Derived Tissues and Satellite Cells

description: <b><i>Background: </i></b>Muscle-derived satellite cells (MDSCs) express MHC molecules intimately related to muscle function, which is supposed to be affected by local estrogen (E<sub>2</sub>) levels. However, cellular targets and molecular mechanisms involved are poorly understood. <b><i>Methods: </i></b>Genioglossus (GG) muscle tissues and MDSCs were derived from SHAM, ovariectomized or ovariectomized and 17 β-estradiol injected rats (n=10 ⁄ group). ERα, ERβ, MHC expression and underlying regulatory mechanisms were investigated by RT-PCR, western blot and immunohistochemistry, inter alia upon selective antagonist exposure and Si-RNA transfection. MDSC viability and cell cycle were examined by MTT and flow cytometry. <b><i>Results: </i></b>E<sub>2</sub> upregulated MHC-I and downregulated MHC-IIb expression in MDSCs. E<sub>2</sub> mediated effects on these molecules were inhibited by ERα-selective antagonist MPP and si-ERα, whereas they persisted upon exposure to ERβ-selective antagonist PHTPP. ERα was significantly higher expressed in muscle tissues compared to ERβ. ER positive stainings were fewer in the ovariectomized than in the SHAM group. Injection of E<sub>2</sub> only increased the positive staining of ERα, but not of ERβ. <b><i>Conclusion: </i></b>Results suggest that E<sub>2</sub> regulates MHC expression mainly through an ERα-mediated pathway with opposing effects on MHC-I and MHC-IIb. Thus, different hormonal processes that impact muscular pathophysiology presumably govern the functional properties of these molecules.
DOI: 10.6084/m9.figshare.5241595
title: Erratum: Serial Changes of Serum Endostatin and Angiopoietin-1 Levels in Preterm Infants with Severe Bronchopulmonary Dysplasia and Subsequent Pulmonary Artery Hypertension

description: <b><i>Background:</i></b> In bronchopulmonary dysplasia (BPD), disrupted angiogenesis may result from an imbalance between pro- and anti-angiogenic factors triggered by inflammation, leading to the late development of pulmonary artery hypertension (PAH). <b><i>Objectives:</i></b> To investigate whether the levels of serum endostatin (as an anti-angiogenic factor) and angiopoietin-1 (AP-1; as a pro-angiogenic factor) in early life are associated with the development of PAH in preterm infants with severe BPD. <b><i>Methods:</i></b> In this prospective cohort study, the levels of serum endostatin and AP-1 were measured from 56 infants (gestational age &lt;30 weeks or birth weight &lt;1,250 g) including severe BPD with PAH (‘PAH'; 15 infants) or without PAH (‘non-PAH'; 22 infants) and no/mild BPD (19 infants) groups on days 1, 7, 14, and 28 of life. <b><i>Results:</i></b> The PAH group consistently underwent more aggressive respiratory management than the non-PAH group, over 1 month after birth. The endostatin level and the ratio of endostatin to AP-1 on day 7 of life were significantly higher in the PAH group than in the non-PAH group or no/mild BPD groups (median 146.6 vs. 102.4/108.0 ng/ml; 62.1 vs. 18.6/14.9). The ratio of endostatin to AP-1 on day 1 was also significantly higher in the PAH group than in the no/mild BPD group (median 31.8 vs. 11.3). <b><i>Conclusions:</i></b> An increased serum endostatin to AP-1 ratio may reflect impaired angiogenesis that may preclude the development of PAH.