cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.25442/hku.20506574
title: Supporting data for "Exploring how systemic inflammation affects the neurotoxic accumulation of α-synuclein" Part 2

description: This dataset explores the neurotoxic effect inflammation and oxidative damage has on the accumulated, phoshorylated alpha-synuclein induced by recombinant preformed fibrils. Recombinant preformed fibrils of alpha-synuclein effectively induce phosphorylation and accumulation of alpha-synuclein into Lewy Body-like inclusions, but exactly how these inclusions lead to neuronal death remains elusive. To examine early stress responses, the phoshorylation of tau and the formation of stress granules were examined <em>in vitro</em> by confocal imaging. The dataset reveals a relationship between phosphorylated, aggregated alpha-synuclein and the formation of stress granules.<em> </em>To examine how oxidative damage or inflammation affects the neurotoxity of phoshorylated alpha-synuclein induced by recombinant preformed fibrils of alpha-synuclein <em>in vivo</em>, the hippocampal neuronal density, tau phoshorylation, oxidative damage and inflammation was evaluated using confocal imaging. To further examine the functional role microglia have in this modulation, microglial phagocytosis was evaluated using confocal imaging of cultured primary microglia. The study reveals a relationship between phosphorylated, aggregated alpha-synuclein and the formation of stress granules, where inflammation regulates the neurotoxic outcome <em>in vivo</em>.
DOI: 10.25442/hku.20506574.v1
title: Supporting data for "Exploring how systemic inflammation affects the neurotoxic accumulation of α-synuclein" Part 2

description: This dataset explores the neurotoxic effect inflammation and oxidative damage has on the accumulated, phoshorylated alpha-synuclein induced by recombinant preformed fibrils. Recombinant preformed fibrils of alpha-synuclein effectively induce phosphorylation and accumulation of alpha-synuclein into Lewy Body-like inclusions, but exactly how these inclusions lead to neuronal death remains elusive. To examine early stress responses, the phoshorylation of tau and the formation of stress granules were examined <em>in vitro</em> by confocal imaging. The dataset reveals a relationship between phosphorylated, aggregated alpha-synuclein and the formation of stress granules.<em> </em>To examine how oxidative damage or inflammation affects the neurotoxity of phoshorylated alpha-synuclein induced by recombinant preformed fibrils of alpha-synuclein <em>in vivo</em>, the hippocampal neuronal density, tau phoshorylation, oxidative damage and inflammation was evaluated using confocal imaging. To further examine the functional role microglia have in this modulation, microglial phagocytosis was evaluated using confocal imaging of cultured primary microglia. The study reveals a relationship between phosphorylated, aggregated alpha-synuclein and the formation of stress granules, where inflammation regulates the neurotoxic outcome <em>in vivo</em>.
DOI: 10.6084/m9.figshare.20551371
title: Water deficit tolerance of bean cultivars

description: Abstract The objective of this work was to evaluate the response of the Garapiá, Triunfo, and BRS-FC104 bean (Phaseolus vulgaris) cultivars to the water deficit represented by the fraction of transpirable soil water (FTSW). The experimental design was completely randomized in a 3×2 bifactorial arrangement (cultivars × irrigation and no irrigation). Transpiration, growth, and yield were evaluated in the crop season and off-season. In the crop season, with a low atmospheric air demand (below 15 hPa in 55% of the days), 'Garapiá' presented early stomatal closure with the critical FTSW (FTSWc) of 0.36, but had the same yield as 'Triunfo', whose stomata closed late (FTSWc = 0.23). In the off-season, with a high atmospheric air demand (greater than 15 hPa in 83.3% of the days), 'Garapiá' presented an early stomatal closure (FTSWc = 0.17) and a higher yield (392.2 kg ha-1 more than 'Triunfo'). In the crop season and off-season, 'Garapiá' showed tolerance to water deficit in the reproductive period. Water deficit resulted in lower values of height, shoot dry mass, root dry mass, and leaf area. Both 'Garapiá' and 'Triunfo' showed a high yield in the crop season, but only 'Garapiá' in the off-season. 'Garapiá' presents tolerance to water deficit, with efficient stomatal control and high growth and yield.
DOI: 10.6084/m9.figshare.20551371.v1
title: Water deficit tolerance of bean cultivars

description: Abstract The objective of this work was to evaluate the response of the Garapiá, Triunfo, and BRS-FC104 bean (Phaseolus vulgaris) cultivars to the water deficit represented by the fraction of transpirable soil water (FTSW). The experimental design was completely randomized in a 3×2 bifactorial arrangement (cultivars × irrigation and no irrigation). Transpiration, growth, and yield were evaluated in the crop season and off-season. In the crop season, with a low atmospheric air demand (below 15 hPa in 55% of the days), 'Garapiá' presented early stomatal closure with the critical FTSW (FTSWc) of 0.36, but had the same yield as 'Triunfo', whose stomata closed late (FTSWc = 0.23). In the off-season, with a high atmospheric air demand (greater than 15 hPa in 83.3% of the days), 'Garapiá' presented an early stomatal closure (FTSWc = 0.17) and a higher yield (392.2 kg ha-1 more than 'Triunfo'). In the crop season and off-season, 'Garapiá' showed tolerance to water deficit in the reproductive period. Water deficit resulted in lower values of height, shoot dry mass, root dry mass, and leaf area. Both 'Garapiá' and 'Triunfo' showed a high yield in the crop season, but only 'Garapiá' in the off-season. 'Garapiá' presents tolerance to water deficit, with efficient stomatal control and high growth and yield.
DOI: 10.6084/m9.figshare.20728878
title: Mathematical Reasoning in Algebraic and Geometric Contexts: an analysis with grade 9 medalist students

description: Abstract The purpose of this article is to understand the reasoning processes of grade 9 students employed in solving two tasks: one of an arithmetic/algebraic nature and another of flat geometry. The methodology used is qualitative, inscribed in an interpretive paradigm using document analysis of six written productions by four students: medalist students at the Brazilian Mathematics Olympiad in Public Schools (OBMEP) and at the Regional Mathematics Olympiad (ORM) in the State of Santa Catarina. The analysis of the students’ solutions was carried out according to the following categories: (i) processes and types of reasoning and (ii) representations. The results point to a great potential of the use of Algebra (with mastery of algebraic language) in the realization of the students’ justifications. Such use seems to have allowed students to diversify their semiotic representation records and to coordinate them. Furthermore, and in a different way from what is reported in the literature, the students were able to carry out their justifications without the need to be questioned by the teacher. This question seems to be associated with the fact that these students are medalists in Mathematics Olympiads, events in which the construction of a plausible justification assumes a central role.
DOI: 10.6084/m9.figshare.20728878.v1
title: Mathematical Reasoning in Algebraic and Geometric Contexts: an analysis with grade 9 medalist students

description: Abstract The purpose of this article is to understand the reasoning processes of grade 9 students employed in solving two tasks: one of an arithmetic/algebraic nature and another of flat geometry. The methodology used is qualitative, inscribed in an interpretive paradigm using document analysis of six written productions by four students: medalist students at the Brazilian Mathematics Olympiad in Public Schools (OBMEP) and at the Regional Mathematics Olympiad (ORM) in the State of Santa Catarina. The analysis of the students’ solutions was carried out according to the following categories: (i) processes and types of reasoning and (ii) representations. The results point to a great potential of the use of Algebra (with mastery of algebraic language) in the realization of the students’ justifications. Such use seems to have allowed students to diversify their semiotic representation records and to coordinate them. Furthermore, and in a different way from what is reported in the literature, the students were able to carry out their justifications without the need to be questioned by the teacher. This question seems to be associated with the fact that these students are medalists in Mathematics Olympiads, events in which the construction of a plausible justification assumes a central role.
DOI: 10.5281/zenodo.4485861
title: Investigating Transformers as Context-aware Word Search Engines - Data and Code

description: This is the review version, please use the published record: https://zenodo.org/record/6425595 Data and code for the paper 'Investigating Transformers as Context-aware Word Search Engines' as submitted for review at ACL21.
DOI: 10.5281/zenodo.4485860
title: Investigating Transformers as Context-aware Word Search Engines - Data and Code

description: This is the review version, please use the published record: https://zenodo.org/record/6425595 Data and code for the paper 'Investigating Transformers as Context-aware Word Search Engines' as submitted for review at ACL21.
DOI: 10.6084/m9.figshare.20728881
title: The Moderating Role of Firm’s Level of Participation in a Cluster in the Relation between Absorptive Capacity and Sustainability Practices

description: ABSTRACT Objective: this study aimed to analyze the moderating role of the firm’s participation level in a cluster in the relation between absorptive capacity and economic, social, and environmental sustainability practices. Methods: data were collected through a survey applied to 417 small and medium-sized firms participating in clusters. Results: results indicate that the absorptive capacity influences positively and directly the adoption of economic, social, and environmental sustainability practices. Such relations are moderated by the firm’s level of participation in a cluster. Conclusions: we conclude that it is vital for the firm to seek external information and use it in line with the information and resources it already has to generate economic, social, and environmental sustainability practices. In addition, firms with a higher level of participation in a cluster are more likely to grow, establish partnerships, carry out innovation, and increase productivity.
DOI: 10.6084/m9.figshare.20728881.v1
title: The Moderating Role of Firm’s Level of Participation in a Cluster in the Relation between Absorptive Capacity and Sustainability Practices

description: ABSTRACT Objective: this study aimed to analyze the moderating role of the firm’s participation level in a cluster in the relation between absorptive capacity and economic, social, and environmental sustainability practices. Methods: data were collected through a survey applied to 417 small and medium-sized firms participating in clusters. Results: results indicate that the absorptive capacity influences positively and directly the adoption of economic, social, and environmental sustainability practices. Such relations are moderated by the firm’s level of participation in a cluster. Conclusions: we conclude that it is vital for the firm to seek external information and use it in line with the information and resources it already has to generate economic, social, and environmental sustainability practices. In addition, firms with a higher level of participation in a cluster are more likely to grow, establish partnerships, carry out innovation, and increase productivity.
DOI: 10.24400/802406/sjre-s70y
title: 4 MMS spacecraft SCM L2 High-Speed Burst Quicklooks (PNG)

description: SCM high-speed burst quicklooks [32-8192Hz] shows from top to bottom : omnidirectional power spectral densities (nT^2/Hz), integrated power (nT^2), orbit view, spacecraft formation. All data are plotted in GSE.
DOI: 10.34740/kaggle/dsv/4138293
title: AutoXGB
DOI: 10.25403/upresearchdata.19928162
title: Analysis of delta-9-tetrahydrocannabinol, cannabidiol and cannabinol

description: These datasets consist of a gas chromatography-mass spectrometry method for the detection and quantitation of cannabinoids was developed and validated in aqueous and oral fluid matrices.The behaviour of Δ9-tetrahydrocannabinol and cannabidiol was further characterised in terms of the pre-analytical parameters and a significant difference was illustrated between the two matrices. The detection and quantification of cannabinoids within biological matrices are still required, despite the legalisation of cannabis use in South Africa. The development of a fit-for-purpose analytical method for the quantification of cannabinoids in biological matrices other than urine is paramount to accommodate the recent legalisation of cannabis use in South Africa. The limit of quantitation of 2.0 ± 0.5 ng/mL (at 95% confidence level) for Δ9- tetrahydrocannabinol in oral fluid was lower than the proposed threshold limit of 5 ng/mL instated in other countries. It was concluded that oral fluid has the potential to serve as an alternative matrix to urine when testing for cannabis use but the sampling uncertainty associated with the collection of authentic oral fluid samples has yet to be determined.It was concluded that the more convenient aqueous matrices cannot be used as a substitute for authentic oral fluid during method validations.
DOI: 10.25403/upresearchdata.19928162.v1
title: Analysis of delta-9-tetrahydrocannabinol, cannabidiol and cannabinol

description: These datasets consist of a gas chromatography-mass spectrometry method for the detection and quantitation of cannabinoids was developed and validated in aqueous and oral fluid matrices.The behaviour of Δ9-tetrahydrocannabinol and cannabidiol was further characterised in terms of the pre-analytical parameters and a significant difference was illustrated between the two matrices. The detection and quantification of cannabinoids within biological matrices are still required, despite the legalisation of cannabis use in South Africa. The development of a fit-for-purpose analytical method for the quantification of cannabinoids in biological matrices other than urine is paramount to accommodate the recent legalisation of cannabis use in South Africa. The limit of quantitation of 2.0 ± 0.5 ng/mL (at 95% confidence level) for Δ9- tetrahydrocannabinol in oral fluid was lower than the proposed threshold limit of 5 ng/mL instated in other countries. It was concluded that oral fluid has the potential to serve as an alternative matrix to urine when testing for cannabis use but the sampling uncertainty associated with the collection of authentic oral fluid samples has yet to be determined.It was concluded that the more convenient aqueous matrices cannot be used as a substitute for authentic oral fluid during method validations.
DOI: 10.6084/m9.figshare.20728893.v1
title: Mathematical knowledge of prospective teachers: learning in a lesson study

description: Abstract We aim to observe the learning of two prospective elementary teachers in the domain of mathematical knowledge, in the topic of Sequences and Regularities , during their participation in a lesson study and see their perceptions about their learning. We followed a qualitative approach and interpretive paradigm, within design-based research. We collected data using participant observation, researchers’ journal, document collection and semi-structured. We mobilized the Mathematics Teacher’s Specialised Knowledge model to analyze data, more specifically, in the field of mathematical knowledge. The results show that future teachers developed their mathematical knowledge, in the subdomain of knowledge about the topic, by practicing concepts, procedures and representation registers; knowledge about the structure of mathematics, when establishing connections based on simplification and increasing complexity and knowledge of mathematical practices, when applying their reasoning, justification and generalization strategies in solving tasks.
DOI: 10.6084/m9.figshare.20728893
title: Mathematical knowledge of prospective teachers: learning in a lesson study

description: Abstract We aim to observe the learning of two prospective elementary teachers in the domain of mathematical knowledge, in the topic of Sequences and Regularities , during their participation in a lesson study and see their perceptions about their learning. We followed a qualitative approach and interpretive paradigm, within design-based research. We collected data using participant observation, researchers’ journal, document collection and semi-structured. We mobilized the Mathematics Teacher’s Specialised Knowledge model to analyze data, more specifically, in the field of mathematical knowledge. The results show that future teachers developed their mathematical knowledge, in the subdomain of knowledge about the topic, by practicing concepts, procedures and representation registers; knowledge about the structure of mathematics, when establishing connections based on simplification and increasing complexity and knowledge of mathematical practices, when applying their reasoning, justification and generalization strategies in solving tasks.
DOI: 10.6084/m9.figshare.20728897
title: Phenolic compounds, antioxidant and antibacterial activity of extract from leaves and bark of Stryphnodendron adstringens (Mart.) Coville

description: ABSTRACT There is currently growing interest in the investigation of bioactive compounds from natural sources. In this context, this study investigated the phenolic content, antioxidant capacity, and antimicrobial activity of the hydroalcoholic extract (EHA) of the stem barks and leaves of Stryphnodendron adstringens. Plant parts were extracted with ethanol:water (1:1) and filtered in a vacuum to obtain the crude extract. Phenolic content was determined by the Folin-Ciocalteu method. Antioxidant activity was measured using the DPPH test. The antimicrobial activity of extracts was evaluated against Gram-positive cocci: Staphylococcus aureus (ATCC 25923) and Staphylococcus epidermidis (strain isolated from a patient); and Gram-negative bacilli: Escherichia coli (ATCC 25922) and Pseudomonas aeruginosa (ATCC 27853). The zone of inhibition and the minimum inhibitory concentration (MIC) of the plant extracts were evaluated by the agar diffusion disc method and broth microdilution, respectively. Total phenolic content of the EHAs was higher in stem barks (970.4 mg GAE/g) than in leaves (693.8 mg GAE/g). In the DPPH assay, all extracts showed high antioxidant activity, above 75% at the concentration of 100 μg/mL. About antimicrobial activity, all the EHAs showed effects against Gram-positive bacteria S. aureus andS. epidermidis, whose MIC ranged from 7.81 μg/mL to 62.5 μg/mL. This finding is important since these pathogens are generally resistant to a variety of widely known antibiotics. Therefore, these results are promising and indicate the use of S. adstringens (Mart.) Coville as a natural antioxidant in foods, medicines and also point to its use in antimicrobial therapy.
DOI: 10.6084/m9.figshare.20728897.v1
title: Phenolic compounds, antioxidant and antibacterial activity of extract from leaves and bark of Stryphnodendron adstringens (Mart.) Coville

description: ABSTRACT There is currently growing interest in the investigation of bioactive compounds from natural sources. In this context, this study investigated the phenolic content, antioxidant capacity, and antimicrobial activity of the hydroalcoholic extract (EHA) of the stem barks and leaves of Stryphnodendron adstringens. Plant parts were extracted with ethanol:water (1:1) and filtered in a vacuum to obtain the crude extract. Phenolic content was determined by the Folin-Ciocalteu method. Antioxidant activity was measured using the DPPH test. The antimicrobial activity of extracts was evaluated against Gram-positive cocci: Staphylococcus aureus (ATCC 25923) and Staphylococcus epidermidis (strain isolated from a patient); and Gram-negative bacilli: Escherichia coli (ATCC 25922) and Pseudomonas aeruginosa (ATCC 27853). The zone of inhibition and the minimum inhibitory concentration (MIC) of the plant extracts were evaluated by the agar diffusion disc method and broth microdilution, respectively. Total phenolic content of the EHAs was higher in stem barks (970.4 mg GAE/g) than in leaves (693.8 mg GAE/g). In the DPPH assay, all extracts showed high antioxidant activity, above 75% at the concentration of 100 μg/mL. About antimicrobial activity, all the EHAs showed effects against Gram-positive bacteria S. aureus andS. epidermidis, whose MIC ranged from 7.81 μg/mL to 62.5 μg/mL. This finding is important since these pathogens are generally resistant to a variety of widely known antibiotics. Therefore, these results are promising and indicate the use of S. adstringens (Mart.) Coville as a natural antioxidant in foods, medicines and also point to its use in antimicrobial therapy.
DOI: 10.6084/m9.figshare.20728912
title: Clinical and epidemiological characteristics and individual experiences of illness in men with COVID-19: mixed method study

description: ABSTRACT BACKGROUND: Since the beginning of the coronavirus disease 2019 (COVID-19) pandemic, studies have shown that this disease has affected the male population on a significant scale in various parts of the world, making men one of the main risk groups. OBJECTIVE: To analyze the clinical and epidemiological characteristics and experiences of illness in men with COVID-19. DESIGN AND SETTING: A mixed sequential-explanatory study with cross-sectional and exploratory-descriptive approaches. METHOD: Data was collected from a small municipality located in the central-north region of the state of Bahia, Brazil. Primary quantitative data was extracted from compulsory notification forms from 598 men. Qualitative data from individual interviews of 30 men was analyzed by the Discourse of the Collective Subject method. RESULTS: The findings identified the characterization of reports of suspected and confirmed cases of COVID-19 in men, the organization of the healthcare system, and strategies for the control and combat of COVID-19 directed towards the men of the investigated municipality. They revealed the clinical characteristics based on the collective discourse of men with COVID-19. CONCLUSION: In men, the individual experience of disease explicitly explains the clinical markers of COVID-19 expressed by the self-reported syndromic approach. Additionally, this understanding also explains the behaviors observed in their search for health care, as well as the adoption of prevention and control measures and therapies recommended by health professionals.