cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.28162901
title: Supplementary Material for: Disseminated Marginal Zone Lymphoma in a Patient with Lyme Neuroborreliosis, a case report

description: Background: Lyme borreliosis has been associated with lymphoma, particularly cutaneous lymphomas. The literature is conflicted regarding the effect of antibiotic therapy in cutaneous marginal zone lymphomas (MZL) in individuals with Lyme borreliosis. 
We present a patient diagnosed with Lyme neuroborreliosis (LNB) and disseminated MZL. 

Case: A 67-year-old man was seen due to 6 weeks of neuropathic pain with nightly worsening, headache, and 5 kg weight loss. Two weeks prior to symptom debut he had a tick bite in the left groin, no subsequent rash. A lumbar puncture revealed mononuclear pleocytosis and elevated CSF-protein. The patient was admitted and started on ceftriaxone. The B. burgdorferi intrathecal test showed intrathecally produced Borrelia antibodies, and treatment was changed to doxycycline with a total treatment duration of 21 days. A PET/CT revealed enlarged lymph nodes with increased FDG uptake. On pathological examination, the CSF showed 62% clonal B-cells – compatible with low-grade B-cell lymphoma. Examination of bone marrow and an inguinal lymph node confirmed disseminated MZL. A control lumbar puncture eight weeks later showed declining pleocytosis and clonal B-cells. At last follow-up 20 months later, he was still asymptomatic and had not required antineoplastic treatment.

Conclusion: To our knowledge, this is the first published case of LNB with non-cutaneous B-cell lymphoma treated and remitting on antibiotics alone.
Antibiotic treatment for Borrelia-positive lymphomas has yet to be investigated with high-evidence study designs, so clinicians are encouraged to publish both positive and negative findings relevant to this. We believe this case brings new perspectives to future diagnosis and treatment of lymphomas in patients with verified Lyme borreliosis.
DOI: 10.6084/m9.figshare.28366304
title: Supplementary Material for: Case report and literature review: A 46, XX infant with atypical genitalia diagnosed with primary ovarian insufficiency (POI) caused by HFM1 gene variants

description: Introduction: Primary Ovarian Insufficiency (POI) due to single gene variant is classified as a 46,XX difference of sexual development. Variants in the Helicase Family Member 1 (HFM1) gene are associated with POI in females and non-obstructive azoospermia in males.
Case report：We described a case of POI with unique genital characteristics, including clitoromegaly, fusion of the labia majora, an opening of the urethral meatus at the perineum, and the absence of the vaginal opening. Hormonal analysis revealed hypergonadotropic hypogonadism. Genetic testing identified two variants in the HFM1 gene: c.1978-2A&gt;C and c.2681-3T&gt;A. A comprehensive analysis of published cases with HFM1 gene variations was conducted to summarize the range of variants and phenotypes associated with HFM1 gene mutations.
Discussion：This study connects HFM1 gene variants to external genital malformations, expanding the spectrum of phenotypes related to HFM1 mutations. Clinicians should consider the possibility of POI in 46 XX female infants with atypical genitalia and perform genetic testing for HFM1 to avoid leaving out the diagnosis.
DOI: 10.6084/m9.figshare.28366973
title: Supplementary Material for: Eight cases of Pediatric Acute Onset Neuropsychiatric Syndrome (PANS) with Inflammatory Bowel Disease (IBD): Immunologic Intersections

description: Introduction: Pediatric Acute-Onset Neuropsychiatric Syndrome (PANS) is an immune-mediated disease characterized by abrupt onset neurobehavioral changes. Inflammatory bowel disease (IBD) includes ulcerative colitis (UC) and Crohn’s disease (CD), chronic conditions characterized by gastrointestinal inflammation. We describe eight individuals with both PANS and IBD.
Methods: All individuals with both IBD and PANS were identified from Stanford Immune Behavioral Health Clinic, Cedars-Sinai Medical Center Pediatric Inflammatory Bowel Disease Program, and Dartmouth Neuroimmune Psychiatric Disorders (NIPD) Clinic. Data was collected by chart review.
Results: Eight cases of PANS with IBD were identified. Five were male. Mean age of onset was 9.3 years for PANS and 15.6 years for IBD. PANS preceded development of IBD in 7 of 8 cases by a mean of 8.4 years. Seven patients (88%) had a first-degree relative with an immune-mediated disease, including 5 with psoriasis or psoriatic arthritis. Five patients themselves had arthralgias or arthritis (63%). All of the 5 cases where PANS preceded IBD treatment sufficiently for analysis were free of major behavioral relapses after IBD was managed. 
Conclusion: The triad of PANS, joint complaints, and family history of autoimmunity, including psoriasis, may represent a subset of PANS at heightened risk for IBD and additional immune-mediated disorders. For children with this triad, clinicians should have a low threshold to evaluate for gastrointestinal inflammation with biomarkers like hemoglobin, CRP, fecal calprotectin and diagnostic endoscopy when indicated. PANS symptoms may improve with effective treatment of IBD. The high prevalence of joint complaints in our cohort and psoriasis in first-degree family members suggests this subset of PANS may share immune mechanisms with psoriasis and arthritis. Treatment strategies used in IBD and arthritis should be studied for potential application in PANS.
DOI: 10.6084/m9.figshare.28368320
title: Supplementary Material for: Additive predictive value of left ventricular end-diastolic volume index to the development of persistent atrial fibrillation in non-obstructive hypertrophic cardiomyopathy

description: Objective To evaluate the association between left ventricular diastolic volume index (LVEDVi) and the risk of persistent or long-standing persistent atrial fibrillation (perAF) in non-obstructive hypertrophic cardiomyopathy (NOHCM) patients.
Methods Forty-nigh NOHCM patients with perAF were selected as the case group (NOHCMAF group). A control group comprised 98 NOHCM patients without atrial fibrillation (AF) history.
Results Compared to the control group, patients in the NOHCMAF group were associated with higher CHA2DS2-VASc score (3.0 ± 1.7 vs 2.2 ± 1.1, p=0.003), higher grade of diastolic dysfunction (II/III) (43.3% vs. 19.4%, p&lt;0.001). Meanwhile, they were associated with a larger left atrial diameter (LAD) (46.8 ± 4.7 vs. 39.3 ± 4.5 mm, p&lt;0.001) and a smaller LVEDVi (63.88 ± 15.07 ml/m² vs. 78.86 ± 12.26 ml/m², p&lt;0.001). Multivariate logistic analysis indicated the independent predictive factor of LVEDVi (OR 0.908, CI 0.861 - 0.957, p&lt;0.001). The multivariable models revealed the additive discrimination for perAF by the LVEDVi with a higher C-statistic of 0.945 in combination with age at diagnosis and LAD. The LVEDVi cutoff for predicting perAF was 71 ml/m².
Conclusions LVEDVi was independently associated with the occurrence of perAF in NOHCM patients, demonstrating an incremental value compared to conventional LA parameters. Increased cardiac rhythm monitoring is recommended for patients with LVEDVi ≤ 71 ml/m².
DOI: 10.6084/m9.figshare.28368530
title: Supplementary Material for: Association between periodontitis and carotid atherosclerosis: an updated systematic review and meta-analysis

description: Introduction Current studies on the relationship between periodontitis and carotid atherosclerosis (CAS) remain inconclusive. This updated meta-analysis was conducted to evaluate the relevant observational studies to drive a definite conclusion.
Methods Four major databases were searched for observational studies regarding the relationship between periodontitis and CAS published up to 14 December 2023. Software STATA 14.0 was used to calculate pooled odds ratios (OR) and 95% confidence interval (CI) in random effects model.
Results Twenty-six articles were finally included. Periodontitis was significantly associated with CAS (OR = 1.97, 95% CI = 1.64 – 2.36; p = 0.000)，however, statistical heterogeneity among studies. Sensitivity analysis indicated our results were robust. Although publication bias was observed, odds ratio corrected by the trim-and-fill method was still increased (OR = 1.30, 95% CI = 1.06 – 1.58; p = 0.000).
Conclusion The findings revealed a significant association between periodontitis and CAS. However, long-term randomized controlled trials should be conducted to identify the causality.
DOI: 10.6084/m9.figshare.28374761
title: Supplementary Material for: Valsalva-induced orbital and subcutaneous periorbital emphysema secondary to lamina papyracea dehiscence: case report

description: Introduction: Pneumo-orbit and periorbital subcutaneous emphysema secondary to defects in the sinus wall have been well described in the context of traumatic or surgical sequelae. However, these rarely occur atraumatically in the setting of an idiopathic or congenital sinus wall dehiscence, with a risk for orbital compartment syndrome and irreversible vision loss. We describe a case of idiopathic lamina papyracea dehiscence with resultant pneumo-orbit and elevated intraocular pressure.
Case Presentation: A 28-year-old man experienced a sudden onset of unilateral orbital and subcutaneous periorbital emphysema following Valsalva maneuver. He had unilateral subcutaneous emphysema, crepitus, violaceous discolouration of the lids, and chemosis of the palpebral conjunctiva. Visual acuity was intact and intraocular pressure was mildly elevated. Imaging showed an idiopathic lamina papyracea dehiscence. The patient was advised of sinus precautions with uneventful spontaneous resolution and no visual sequelae. 
Conclusion: Lamina papyracea dehiscence predisposes to spontaneous Valsalva-induced orbital or periorbital emphysema with a risk of elevated intraocular pressure, optic neuropathy, and vision loss; prompt recognition and early management can prevent vision-threatening sequelae.
DOI: 10.6084/m9.figshare.28374881
title: Supplementary Material for: Streptococcus mutans GcrR regulates oral biofilm from a cariogenic state to a non-cariogenic state by affecting exopolysaccharides production and biofilm homeostasis

description: Introduction: Dental caries is a non-communicable disease caused by dysbiosis of dental biofilm. S. mutans is considered the major pathogen. The orphan response regulator GcrR negatively regulates exopolysaccharides (EPSs) synthesis in S. mutans. We aimed to investigate the effect of GcrR on the cariogenicity of oral biofilms. A multispecies biofilm model was constructed, including S. mutans, S. sanguinis, and S. gordonii. Methods: The morphology of multispecies biofilms was detected through scanning electron microscopy (SEM), and the structure was observed using confocal laser scanning microscopy (CLSM). The microbial composition was measured by fluorescence in situ hybridization (FISH) and qPCR. The expression of genes was detected by quantitative RT-PCR (qRT-PCR). A specific pathogen-free (SPF) rat model was used to assess the cariogenicity of the multispecies biofilms. Results: The architecture of the biofilm was significantly impaired when gcrR-overexpressed S. mutans incubated with S. sanguinis, and S. gordonii (SmugcrR++S.s+S.g). The biofilm exhibited a decrease in the production of water-insoluble glucans (WIGs) and water-soluble glucans (WSGs), consistent with a decreased expression of EPS synthesis-related genes. The SmugcrR++S.s+S.g biofilm exhibited an increase in non-cariogenic species with lower lactic acid production. Furthermore, SmugcrR++S.s+S.g biofilm exhibited reduced cariogenicity. Conclusion: The biofilm cariogeneicity could be shifted to a less cariogenic state by increased expression of the GcrR regulator.
DOI: 10.6084/m9.figshare.28374998
title: Supplementary Material for: Hedgehog signaling during gut formation in the freshwater leech, Helobdella austinensis

description: Introduction: The hedgehog signaling pathway plays a crucial role in inducing segment polarity through cell-cell interactions in various metazoans, including arthropods and annelids. However, its involvement in organogenesis and segmentation among lophotrochozoans remains inconsistent. This study aimed to explore the role of the hedgehog gene during gut development in the freshwater leech, Helobdella austinensis. Methods: Developmental RT-PCR and in situ hybridization were performed to examine the expressions of hedgehog genes. In addition, embryos were treated with Cyclopamine (a hedgehog signaling antagonist) and Purmorphamine (a Smo agonist) to examine the potential interactions between Helobdella orthologs to hedgehog and two NKL genes: Hau-NK2 and Hau-NK4. Results: We examined the expressions of four core pathway members - Hedgehog (Hh), Patched (Ptc), Smoothened (Smo), and the downstream transcription factor Gli - spatiotemporally during the embryonic stages of H. austinensis. All four genes were expressed in the developing gut and proboscis during organogenesis but not during the segmentation stage. Additionally, the treatment of embryos with Cyclopamine and Purmorphamine revealed that NK genes are regulated by hedgehog signaling. Furthermore, NK2 and NK4 were expressed in the developing gut rather than in a segmental stripe pattern. Conclusions: This study confirms that the hedgehog signaling pathway is associated with gut development in the freshwater leech, Helobdella austinensis. The expression patterns of hedgehog pathway genes and their interaction with NK genes suggest a role for hedgehog signaling in regulating gut development rather than segmentation in the freshwater leeches.
DOI: 10.6084/m9.figshare.28379654
title: Supplementary Material for: Comprehensive immune landscape in allergic conjunctivitis: insights from Mendelian randomization analysis

description: Introduction: Current understanding of the immune landscape underlying allergic conjunctivitis (AC) remains rather limited. We investigated the potential association between circulating immunophenotypes and AC using Mendelian randomization (MR) methodology. 
Methods: Based on genome-wide association studies (GWAS) summary-level statistics, a 2-sample MR was employed to analyze the bidirectional causal relationships between 731 circulating immunophenotypes and AC risk. 
Results: A total of 33 genetically predicted immunophenotypes were significantly associated with AC risk. A protective effect of 18 immunophenotypes against AC was found, such as CD3 on CD39+CD8br (Inverse variance weighted [IVW] odds ratio [OR] = 0.936, 95% confidence interval [CI]: 0.925-0.985, p = 0.003) and CD25 on CD28+CD4+ (IVW OR = 0.921, 95% CI: 0.863-0.983, p = 0.013). Conversely, 15 immunophenotypes were found to be significantly associated with AC risk, such as CD25 on IgD–CD38dim (IVW OR = 1.042, 95% CI: 1.012-1.073, p = 0.006). Reverse MR based on these 33 genetically predicted immunophenotypes suggested that AC also had a significant influence on four circulating immune cells, including CD33–HLA DR– AC (IVW OR = 1.187, 95% CI: 1.034-1.362, p = 0.015), CD3 on CD39+CD8br (IVW OR = 0.876, 95% CI: 0.779-0.985, p = 0.027), HLA DR on CD14+ monocyte (IVW OR = 0.831, 95% CI: 0.725-0.953, p = 0.008), and CD39 on CD39+ secreting Treg (IVW OR = 1.123, 95% CI: 1.002-1.259, p = 0.046). 
Conclusion: Our study highlights the intricate association between immune cells and AC, providing a valuable basis for future mechanistic and therapeutic studies from an immunological perspective.
DOI: 10.17632/2s5m3crbkd.2
title: Screening datasets for laser welded steel-copper lap joints

description: V1: The data show a definitve screening design to evaluate the the influence of six factors (laser beam power (W), welding speed (m/min), angular position in welding direction (°), focal positon (mm), gas flow rate (l/min), material thickness of the steel sheet (mm)) in three levels and 18 parameter combinations on the weld depth and the geometrical dimensions of the weld metal in laser welded steel-copper joints in the lap configuration with steel on the top side. Every parameter combination was repeated 5 times and every sheet was cuttet 4 times to overall generate 360 cross sections. Every line in the dataset stands for a cross section which was evaluated regarding the dimensions of the weld metal. Additionally, there was a dichotomous data column added for cracking in the weld metal (yes/no). The dataset is not suitable for modelling a precise predicting model of weld depth in the copper sheet, but shows a correlation between cracking (yes/no) and the weld depth in the copper sheet. This can be discribed very well in a binominal logistic regression. Moreover the average crack lenght and count of cracks was added in Versions V1.1 V2: The data show the same screening experiments but with adjusted laser power levels to garantee sufficient weld depth for all parameter combinations (which was lacking in V1). The target is the average weld depth in the bottom copper sheet for every parameter combination. The data can be used to calculate the parameter effect strenght of the different factors on the weld depth and to build a simple linear model of the coherences between the parameters and the resulting weld depth. V2.1 ist basically the same dataset but with the resulting copper dilution instead of the weld depth.
DOI: 10.25318/4210005301-eng
title: Parental child care expenses for main child care arrangement, children aged 0 to 5 years

description: Median and mean parental child care expenses for main child care arrangement for children aged 0 to 5 years, by age group, main child care arrangement, hours of child care per week, and timeframe of payment for child care.
DOI: 10.5067/sevv4mr8p1zn
title: MEaSUREs Antarctic Boundaries for IPY 2007-2009 from Satellite Radar, Version 1
DOI: 10.5281/zenodo.14193759
title: Multimodal mismatch responses in mouse auditory cortex

description: All raw data and Matlab code necessary to produce the figures of https://elifesciences.org/reviewed-preprints/95398
DOI: 10.5281/zenodo.3735781
title: Implementation of the wildlife monitoring standard on excel

description: Enetwild consortium developed a data standard on wildlife monitoring data to aggregate raw data such as occurrences, drive hunt hunting bags, distance sampling data, or aggregated or estimated data such as density estimates, summarized hunting bags, probability of presence. This standard is based on the Darwin Core standard, using the Event core, the Occurrence extension, the extended measurement or fact extension. We proposed to extend the measurement or fact extension to allow them to be nested among themselves for recording confidence intervals and precision information. We offer the possibility to nest occurrences within each other as well. We propose controlled vocabularies in relation to statistical information, in both data and metadata. In addition to a single metadata sheet, this Excel file proposes two ways to enter a dataset. The first option is to record events, occurrences, and measurements in different sheets, which is similar to the option proposed by GBIF in its Integrated Publishing Toolkit. The second option is to record events, occurrences and measurements in a single sheet (data_AllInOne) with the help of conditional formatting, working on the most recent version of Excel. This is in line with the EFSA data model harmonisation under the SIGMA project.
description: EU; xls; alpha@efsa.europa.eu
DOI: 10.6084/m9.figshare.28368218
title: Supplementary Material for: Failures of Sealed Molars: Three-Year Results from a Multi-Center, Prospective Study in Public Dental Service in Norway

description: The efficacy of fissure sealants (FS) in controlling occlusal caries is well documented. However, several factors can potentially modify the caries-preventive effect of FS and their failure rate in real life might be higher than in controlled experimental settings. 

The aim of this study was to prospectively examine failures and risk factors in sealed first permanent molars (FPMs) with sound occlusal surfaces or initial caries lesions of children in a practice-based setting in public dental service (PDS) in Norway. Methods. Children aged 6 to 10 years considered at high caries risk (D3MFT/d3mft &gt; 0) were recruited by dentists and dental hygienists during routine examination at local dental clinics in PDS. After the application, resin-based FS were maintained according to clinicians’ conventional procedures. Occlusal surface/FS status and the following treatment were registered at 6- , 12-, 24- and 36-months. The outcome was categorized into success, minor failure, and failure of sealed FPM based on a combination of diagnosis of occlusal surface/FS status and the following treatment at each follow-up. Univariable and multivariable Cox survival analyses were used to investigate potential risk factors for failure. 

Results. Out of 409 participants, 4% (16) were lost to follow-up. Of 393 FPMs, 72% (284) were evaluated as success, 9% (34) as minor failure, and 19% (75) failed during the 36-months of this study period: 13% (51) received FS reapplication and 6% developed dentine caries or were restored. One third of FS were additionally treated with fluoride varnish (FV) at least once during the follow-up. Occlusal surface with caries grade 1-2 (vs intact) increased (adHR 1.9, 95% CI 1.1-3.1), while FV application over FS decreased hazards (adHR 0.4, 95% CI 0.3-0.7) for failure. The clinic’s county was associated with failure. 

Conclusion. After 3-year follow-up, nearly one out of five sealed FPMs failed, i.e., had to be resealed, developed dentine caries, or were restored. Initial caries lesion on occlusal surface increased while FV application over FS reduced risk for failure. Moreover, regional differences in sealed FPM failures were observed.