cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.17632/yf2dgcfmmh.2
title: mHeart - mHealthCare Platform Adapted to the Heart Transplant Population - Technical Specifications and Software Source Code

description: The information is provided to increase the data transparency and the scalability of eHealth research and particularly the mHeart studies scalability. This dataset contains relevant information on: - The mHealthCare Platform Technological Description and Specifications - The mHeart source code of the 3 applications (website, app Android, app Apple) - A video of the clinical use of the mHeart mobile application. - An apk file with a DEMO (Spain Version 2015). Please, notice that this is a dynamic process. Multiples versions will be uploaded since mHeart was developed. Consult the DEMO access directly on Stores. - User Guidelines (Spain Version 2015) - Scientific Authorship Statement - mHeart trademark The mHealthCare Platform is an internet-based system to carry out integral healthcare for disease and therapy management in any population. The first version uploaded in Hospital de la Santa Creu i Sant Pau (HSCSP) was directed at transplant populations and was specifically adapted to the heart transplant population in the ambulatory setting. The mHeart program has been classified by authors as a Behavior Intervention Technology (BIT) to facilitate the following overall clinical goals: (1) health behavior change (i.e. increase patients’ healthy behaviors and prevent the onset of disease); and (2) targeted disease management (i.e. facilitate therapeutic interventions and improve patient’s self-management). The mHeart tool is a mobile phone app connected to a website for use by providers and patients. The tool can be used simultaneously on distinct devices to facilitate caregiver and guardian support. The mobile application can be downloaded for free from the Google and Apple online stores. The website link is salud.trilema.es. The system was developed by Socioemprende SL Technical Team. Scientific advice was provided by the heart transplant interdisciplinary healthcare team and directed by the Pharmacy Department, HSCSP. For further questions about the System, please contact with the scientific coordinator Mar Gomis-Pastor: mar@margomis.com
DOI: 10.5061/dryad.h77450k/1
title: Dryad Item 10.5061/DRYAD.H77450K/1

description: (:tba)
DOI: 10.5061/dryad.h77450k/2
title: Dryad Item 10.5061/DRYAD.H77450K/2

description: (:tba)
DOI: 10.17632/6xsthkk47x.1
title: Mosque Panic Evaluation-Ahmet Hamdi Akseki

description: Pathfinder File
DOI: 10.17632/vywrrtywk4.1
title: Suspicious Ultrasound Characteristics, IMC and Brafv600e mutation associated with central lymph node metastasis

description: From January 2016 to March 2018, we identified a cohort of patients with classic papillary thyroid carcinoma who underwent cervical US and were diagnosed by postoperative pathology. Fine-needle aspiration biopsies were analyzed for the presence of BRAFV600E, and immunohistochemistry was used to detect tumor markers. US imaging was performed in accordance with a standardized protocol. A model to determine the risk of central lymph node metastasis was established using the outcomes of univariate and multivariate analyses.
DOI: 10.5061/dryad.h77450k/3
title: Dryad Item 10.5061/DRYAD.H77450K/3

description: (:tba)
DOI: 10.5061/dryad.h77450k/4
title: Dryad Item 10.5061/DRYAD.H77450K/4

description: (:tba)
DOI: 10.5061/dryad.h77450k/5
title: Dryad Item 10.5061/DRYAD.H77450K/5

description: (:tba)
DOI: 10.5061/dryad.h77450k/6
title: Dryad Item 10.5061/DRYAD.H77450K/6

description: (:tba)
DOI: 10.5061/dryad.h77450k/7
title: Dryad Item 10.5061/DRYAD.H77450K/7

description: (:tba)
DOI: 10.5061/dryad.h77450k/8
title: Dryad Item 10.5061/DRYAD.H77450K/8

description: (:tba)
DOI: 10.5061/dryad.h77450k/9
title: Dryad Item 10.5061/DRYAD.H77450K/9

description: (:tba)
DOI: 10.17632/crmtpmd622.1
title: Nutrient High-Throughput Screen Identifies Bacterial Effectors of Metformin Therapy. Pryor et al
DOI: 10.17632/gw6hfmwjmp.2
title: gingko 20-year height plot data and occurrence locations

description: Gingko 20-year height plot data from 45 sample plots and 351 occurrence locations. These datasets were used to build and validate a climatic response function for "Predicting growth and habitat responses of Ginkgo biloba L. to climate change." to be published in Annals of Forest Science.
DOI: 10.5061/dryad.4q1s881/1
title: Dryad Item 10.5061/DRYAD.4Q1S881/1

description: (:tba)
DOI: 10.5061/dryad.4q1s881/2
title: Dryad Item 10.5061/DRYAD.4Q1S881/2

description: (:tba)
DOI: 10.5281/zenodo.3377419
title: Ptolemy's catalogue of localities of the Iberian peninsula

description: Extract of Ptolemy's geographical catalogue, covering the localities of the Iberian peninsula (Geography 2.4-2.6) of the two main textual recensions of the work (Xi and Omega), based on the Greek text edited by (@StueckelbergerGrasshoff2006). The coordinates of the Xi recension follow the readings of the Vaticanus gr. 191, as they are edited in the main text together with the critical apparatus by the editors.
DOI: 10.21227/t3e2-0535
title: Solar Pump

description: Inconvenience regretted, please visit page in september/october.This dataset is a series of experiments, which contain simulation results,comparisons ,animated phase portraits. This dataset is original,not plagiarised data generated using examples available on net or in demo but rather results have been generated for a project which will be onsite implemented for domestic/residential and to studySolar Panels are connected to generate singlephase DC.MPPT algorithm is used to, which is then boosted toPumps used for ,
DOI: 10.7910/dvn/lm24kw
title: deleteTest

description: Test beshcrijving haha
DOI: 10.7910/dvn/lm24kw/gsbezu
title: async std
DOI: 10.14457/cu.the.2012.257
title: Elderly – friendly condominium design for intergenerational families in Bangkok

description: Intergenerational households in Thailand are the result of Thai’s cultural values and beliefs, practiced throughout generations, forming the traditionally preferred living arrangements for Thai elderly. Adult children were to be responsible of their elderly parents’ welfare. However, changing attitudes and conflicts among family members have driven elderly parents away from living with their children. Conflicts within intergenerational households can be reduced through appropriate levels of privacy and intimacy. Nursing home is not an option preferred by elderly parents. The objective of this thesis is to redesign and reconfigure living space suitable for the elderly and their intergenerational families in Bangkok. This will raise awareness on safe living environment for the elderly in intergenerational families. The study focuses on designing an elderly-friendly condominium for intergenerational families to live together without family conflicts. In order to understand elderly in intergenerational families in Bangkok, previous literatures on the topic were reviewed. Recent studies showed that Thai elderly prefer to live separately from their children to avoid conflicts, but still believe that intergenerational living arrangement is beneficial. Related laws and regulations facilitating the elderly and handicaps in Thailand were reviewed as guidelines for an elderly-friendly environment. Case studies on nursing homes and condominium designs were conducted to understand spaces designed for Thai elderly. In addition, six intergenerational households, and a residence designed for a large intergenerational family were analyzed to understand how the living spaces were configured to fit each family’s needs. An elderly - friendly condominium for intergenerational families is derived. A site in Bearing is selected in consideration to land price and availability, as well as the conveniences of transportation, and its surrounding amenities for the elderly and the family. The condominium has a large building footprint to keep the number of floors low, for the safety of the elderly. The condominium gives alternatives for the elderly and adult family to either coreside as neighbors by living on designated floors, or together in intergenerational duplex units. Duplex rooms are reconfigured to enhance privacy and designated area for intimacy, so families can live together in harmony without the family conflicts. Private common areas are provided to enrich the elderly’s lives; and located to enhance natural ventilation. Medical and recreational facilities provided are open to the public to encourage social interactions between the elderly and the community, offering a safe living environment to support an active lifestyle. The thesis offers an elderly orientated vertical living environment within the context of Bangkok, as well as options to support intergenerational living.
DOI: 10.14457/cu.the.2012.258
title: Formulation development and evaluation of glucosamine hydrochloride foaming solution for transdermal delivery

description: Glucosamine hydrochloride (GS HCl) is an aminomonosaccharide and classified as symptoms-modifying drug in osteoarthritis. This study focused on development of glucosamine foam preparation. The effect of component of foam formulation on the permeation across the pig ear skin in vitro were elucidated using Franz-diffusion cell at 32⁰C for 24 hours and stability of GS HCl foam formulation were determined quanlitatively using validated HPLC method by pre-column derivetization with phenylisothiocyanate (PITC). The percent cumulative amount of permeated drug after 6 hours and the permeability constant (kp) up to 6 hours of various components of formulation was calculated. The potential of enhancing permeability of the surfactant studied can be ranked as the following, Desyl glucoside (cumulative amount of permeated drug 18.05%, kp = 2.20x10-6 cm/s), Caprylyl/Capryl Glucoside (cumulative amount of permeated drug 11.55%, kp = 1.46x10-6 cm/s) and Tween 80 (cumulative amount of permeated drug 10.67%, kp = 1.26x10-6 cm/s). And GS HCl foam containing desyl glucoside was the highest GS HCl permeation which more than solution (cumulative amount of permeated drug 28.05%, kp = 3.10x10-6 cm/s). The formulation with various surfactants prepared from tartrate buffer at pH 3 and sodium metabisulfite as antioxidant and storage at 5⁰C better stability than others. The presence of small quantity of ethanol in preparations could enhance the drug permeability. The results indicate that there is a possibility to develop a GS HCl transdermal dosage forms.
DOI: 10.14457/cu.the.2012.259
title: Nanoencapsulation of mangosteen extract : preparation, release, growth inhibition and anti-adhesion activities of Helicobacter Pylori

description: The nature of Helicobacter pylori to inhabit under the acidic mucus layer of the stomach tissue combined with the increasing rate of acquisition of resistance to antibiotics in clinical isolates of this bacteria have caused failure in the treatment (eradication) of this infectious etiological agent of chronic gastritis and peptic ulcer diseases. Not only are new antibiotics needed, but also an effective method for their localization and controlled release of any such drugs at the site of bacterial residence is also most important. Here, mangosteen extract (GME) and its major active component, α-mangostin, were encapsulated into mucoadhesive nanoparticles fabricated from a 1:1 (w/w) blend of ethyl cellulose (EC) and methyl cellulose (MC). Both prepared nanoparticles showed spherical shape, size around 600 nm, encapsulation efficiency more than 90%, loading capacity 50% approximately and good suspension in water. The GME-loaded EC/MC nanospheres show a sustained release of GME at pH 2.0 and pH 7.4. GME and α-mangostin possessed anti-H. pylori and anti-adhesion activities in vitro. These in vitro activities are also observed and indeed are enhanced when the materials are encapsulated into nanocarriers. Preliminary in vivo tests revealed the ability to combat H. pylori in the stomachs of infected mice following oral administration of the EC/MC encapsulated GME, but not the unencapsulated GME. Moreover, acute toxicity test in mice demonstrated that GME-encapsulated nanoparticles were non-toxic to mice. Thus, nanoencapsulated GME was a potential anti-H. pylori agent.
DOI: 10.14457/cu.the.2012.260
title: Effects of dispersant molecular weight on dispersion and stability of zinc oxide nanoparticle aqueous suspension

description: Aqueous suspensions of zinc oxide (ZnO) nanoparticles are prepared at 0.5 wt% solids content using polyacrylic acid (PAA) as a dispersant. Average primary particle sizes of ZnO powder are 65.31, 174.56 and 224.54 nm and PAA molecular weights are 1.8k, 450k and 3000k g/mol. Particle dispersion and stability of the suspensions are investigated. It is found that PAA(1.8k) exhibits the highest dispersant efficiency for all ZnO sizes. Well-dispersed and highly stable suspensions can be obtained at 0.5 wt% PAA(1.8k). Median agglomerate sizes are 0.18, 0.37 and 1.02 µm for suspensions prepared with ZnO powder of sizes 65.31, 174.56 and 224.54 nm, respectively. The highly stable suspensions are not completely precipitate up to 28 days. However, PAA(450k) and PAA(3000k) are also effective as dispersants when using at higher concentrations. Adsorption amounts of PAAs on ZnO surface are determined and the data exhibits Langmuir isotherm. Evaluated area occupied per molecule of PAAs on various ZnO sizes suggests that low molecular weight PAA adsorbed on particles as loops and tails while high molecular weight PAA mostly adsorbed as tails. Also, PAAs adsorbed as loops and tails on large particles while frequently tails on small particles. These differences in adsorption conformation could directly relate to dispersant efficiency of PAAs. In addition to the effects of PAAs on preparation of ZnO nanoparticle suspensions, its influence on characteristics of ZnO nanoparticles synthesized by precipitation method is also investigated. It is found that primary size of synthesized ZnO nanoparticles can be controlled by PAA concentrations. Increasing of PAA concentration narrow the distribution and shift the size to smaller particles. Average primary particle size of around 20 nm can be obtained with 1 wt% PAAs. Moreover, ZnO particles synthesized using PAAs exhibits higher zeta potential than the one without PAA, and the zeta potential values increase with increasing PAA concentration. It suggests that ZnO particles synthesized using 0.5-1 wt% PAAs should be well-dispersed in aqueous medium and provide a highly stable suspension, which is desired for most applications.
DOI: 10.14457/cu.the.2012.261
title: Roles of adenosine triphosphate (ATP) and gap junction hemichannels in mechanically-stimulated human periodontal ligament cells

description: Mechanical stress is an important factor in maintaining periodontium homeostasis. We previously reported that mechanical stress could activate ATP release in human periodontal ligament (HPDL) cells. In this study, we found that ATP mediated mechanical stress-induced mRNA expression and release of the pro-inflammatory cytokine IL-1β. The released ATP later activates P2 receptor. By using inhibitors and siRNA experiments, we found that P2X7 receptor was the main P2 subtype responsible for ATP-induced upregulation of IL-1β in HPDL cells. In macrophages, Pannexin-1 (Panx1) hemichannel has been proposed to combine with P2X7 receptor, forming a mechanosensitive complex involving in the regulation of IL-1β. In this work, we found that, in the absence of Panx1, upregulation of IL-1β upon both mechanical and ATP stimulation was drastically diminished. Additionally, immunocytochemistry and co-immunoprecipitation revealed the co-localization of P2X7 receptor and Panx1 hemichannel in HPDL cells, which found to be increased after stress application. Results also showed that Panx1 hemichannel might serve as one of the ATP release pathway in HPDL cells. The IL-1β releasing mechanism was also investigated. Pretreatment with vesicular trafficking inhibitors significantly reduced IL-1β release from HPDL cells, while mRNA induction remained unaffected. Membrane co-localization of SNAP-25, a core protein of vesicular-membrane fusion SNARE complex, with P2X7 receptor/Panx1 was observed. Collectively, these data indicated vesicular release of IL-1β. In conclusion, mechanical stress could directly regulate IL-1β expression and vesicular release in HPDL cells through ATP-gated P2X7 receptor/Panx1-dependent pathway. Function of Panx1/P2X7 receptor might be required in the IL-1β induction mechanism, and their possible novel function as docking sites for IL-1β vesicular release was also indicated.
DOI: 10.14457/cu.the.2012.262
title: Genetic Polymorphisms on pharmacokinetics and pharmacodynamics of mycophenolate mofetil in Thai kidney transplant patients

description: The objectives of this study were to investigate the influence of genetic polymorphisms on pharmacokinetics and pharmacodynamics of mycophenolate mofetil in 118 Thai kidney transplant patients. Mean age was 45 years old and most patients received concomitant cyclosporine or tacrolimus therapy. Mean daily dose of mycophenolate mofetil was 1211.86±339.10 mg (range 500-2000 mg). Allele frequencies of UGT1A9*1b, UGT1A9 -688T&gt;G, UGT2B7 802C&gt;T, MRP-2 -24C&gt;T, IMPDH1 125G&gt;A, IMPDH1 -106G&gt;A and IMPDH2 3757T&gt;C were 0.49, 0.12, 0.27, 0.23, 0.41, 0.58 and 0.01, respectively. Seventy eight patients (66.10%) had predicted AUC0-12 hr of mycophenolic acid (MPA) within target range (mean 46.59±8.08 mg x h/L). When considering the association of gene polymorphisms and pharmacokinetic parameters, patients with MRP-2 -24C&gt;T variant had a significantly lower predicted MPA AUC0-12 hr than patients with wild-type gene (5.044 and 5.921 mg x h/L/mg/kg, respectively, p-value = 0.008). In addition, the oral clearance of MPA in patients with MRP-2 -24C&gt;T variant was significantly higher than the oral clearance of MPA in patients with wild-type gene (0.150 and 0.120 L/h/kg, respectively, p-value = 0.025). There were no significantly differences of pharmacokinetic parameters among patients with different polymorphisms of UGT1A9*1b, UGT1A9 -688T&gt;G and UGT2B7 802C&gt;T SNPs. For pharmacodynamic parameters, IMPDH activity was determined. Patients with IMPDH1 125G&gt;A variant had a significantly higher IMPDH activity at predose and 2 hour after morning MMF dose than patients with wild-type gene. No differences of IMPDH activity was found among patients with different polymorphisms of IMPDH1 -106G&gt;A and IMPDH2 3757T&gt;C SNPs. In summary, the effects of MRP-2 SNP on pharmacokinetics and IMPDH1 SNP on pharmacodynamics of mycophenolate mofetil were documented. These genotypes may be the factor for dose guiding and outcome monitoring in Thai kidney transplant patients.
DOI: 10.14457/cu.the.2012.263
title: Characteristics and molecular typing of methicillin-resistant coagulase-positive staphylococci in dogs, dog's owners and veterinarians

description: This study propose the conventional biochemical scheme for species identification of canine coagulase-positive staphylococci (CoPS), S. pseudintermedius, S. schleiferi subsp. coagulans and S. aureus, consisting of acetoin production, assimilation of maltose, galactose, trehalose and lactose in broth base and fermentation of mannitol. The scheme could generate reliable results with genotypic identification and protein pattern analysis. Regarding interspecies transmission, S. pseudintermedius and S. schleiferi subsp. coagulans could be isolated from dog-associated people including veterinarians and dog’s owners but not from people without dog association. With respect to methicillin-resistant trait, MRCoPS could be only recovered from dogs and dog-associated people. The methicillin-resistant S. pseudintermedius (MRSP) was mostly isolated that followed by methicillin-resistant S. schleiferi subsp. coagulans (MRSSc) and methicillin-resistant S. aureus (MRSA), respectively. Using antimicrobial susceptibility test and genetic resistance detection by microarray, over 80% of MRCoPS isolates exhibited multidrug resistance to approved antimicrobials for veterinary use including tetracycline, aminoglycosides, erythromycin, clindamycin, chloramphenicol, trimethoprim, ciprofloxacin and sulfamethoxazole. By multilocus sequence typing (MLST), pulsed-field gel electrophoresis (PFGE) and staphylococcal cassette chromosome (SCCmec) typing, the molecular characteristics revealed that Thai dogs and dog-associated people shared common and various clones of MRCoPS, especially MRSP. These supported the evidence of inter-species transmission of canine MRCoPS between dogs and humans. The standard diagnostic schemes were proposed in this study leading to discovery of multidrug resistance MRCoPS distributing among dogs, veterinarians and dog owners. Thus, to deal with the challenge condition of antimicrobial-resistant bacteria and to diminish the spread to human beings, veterinarians should seriously take action.
DOI: 10.14457/cu.the.2012.264
title: Development of fluorescence pyrrolidinyl peptide nucleic acid as probes for determination of DNA sequences

description: In this research, fluorescence peptide nucleic acid (PNA) probes that can change the fluorescence in response to the presence of correct DNA target were designed and evaluated. The PNA employed in this work is the pyrrolidinyl peptide nucleic acid with an alternating proline/2-aminocyclopentanecarboxylic acid backbone (acpcPNA) which shows superior binding to DNA in terms of stability and specificity compared to DNA and commercial PNA. In the first part, 5-(pyren-1-yl)uracil (UPy) PNA monomer was synthesized and incorporated into the acpcPNA. The UPy base in acpcPNA retained the ability to specifically recognize the base A in its complementary DNA strand. Furthermore, the fluorescence of the UPy base is significantly enhanced when the acpcPNA is hybridized to its complementary DNA target, irrespective of the nature of the flanking bases. The fluorescence enhancement is specific to the pairing between UPy and dA. In the second part, pyrene was covalently attached to N-terminal positions of acpcPNA or to internal positions of APC-modified acpcPNA through a flexible butyryl linker via acylation of the N-termini of acpcPNA or the pyrrolidine nitrogen atom of 3-aminopyrrolidine-4-carboxylic acid (APC)-modified acpcPNA. Hybridization of the terminally pyrene-modified PNA to its complementary DNA gave variable fluorescence change, depending on the original fluorescence of the single stranded PNA and the identity of the DNA base in vicinity of the pyrene label. Hybridization of the internally pyrene-labeled acpcPNA to its complementary DNA target resulted in a consistent large increase in fluorescence signal relative to the single stranded DNA. In the third part, the combination of terminally fluorophore-modified acpcPNAs (Flu- or TMR-acpcPNA) with a short quencher DNA were evaluated as strand-displacement probes for DNA sequence determination. In the presence of complementary DNA, the fluorescence was increased, but never returned to the original level due to incomplete strand displacement and also quenching by the DNA target. In all cases, the high specificity of the acpcPNA system allows unambiguous discrimination between the complementary and single mismatched DNA target.