cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.12214346.v1
title: Global Distribution of Whistler Mode Waves in Jovian Inner Magnetosphere

description: This is the dataset used to produce figures for the paper submitted to Geophysical Research Letters with the title of "Global Distribution of Whistler Mode Waves in Jovian Inner Magnetosphere".
DOI: 10.6084/m9.figshare.12214364.v1
title: Source data for paper entitled "Low-frequency ultrasound-mediated cytokine transfection enhances T cell recruitment at local and distant tumor sites"

description: This is the source data that was used to generate the Figures and Supplementary Figures in the PNAS paper entitled "Low-frequency ultrasound-mediated cytokine transfection enhances T cell recruitment at local and distant tumor sites".
DOI: 10.6084/m9.figshare.12214196
title: Supplementary Material S1: Pilot Study - PsychophysicalData

description: Psychophysical data of supplementary material S1 related to "Large EEG amplitude effects are highly similar across Necker cube, smiley, and abstract stimuli". For more information read the manual: https://doi.org/10.6084/m9.figshare.12214199.v1
DOI: 10.6084/m9.figshare.12214163
title: Peak areas of five YFSJ fractions samples.xlsx

description: Peak areas of five YFSJ fractions samples
DOI: 10.6084/m9.figshare.12214196.v1
title: Supplementary Material S1: Pilot Study - PsychophysicalData

description: Psychophysical data of supplementary material S1 related to "Large EEG amplitude effects are highly similar across Necker cube, smiley, and abstract stimuli". For more information read the manual: https://doi.org/10.6084/m9.figshare.12214199.v1
DOI: 10.6084/m9.figshare.12213773
title: Annex 1

description: Annex 1
DOI: 10.6084/m9.figshare.12213746
title: Learning Controllers for Adaptive Spreading of Carbon Fiber Tows: Preprocessed Data

description: Part of the paper "Learning Controllers for Adaptive Spreading of Carbon Fiber Tows". Preprocessed data, recorded on a spreading system.<br><br><br>
DOI: 10.6084/m9.figshare.12213773.v1
title: Annex 1

description: Annex 1
DOI: 10.6084/m9.figshare.12213737
title: Underlying data

description: Underlying data for model associated with paper titled "cost-effectiveness analysis of an outreach model of care for HCV treatment"<br>
DOI: 10.6084/m9.figshare.12213737.v1
title: Underlying data

description: Underlying data for model associated with paper titled "cost-effectiveness analysis of an outreach model of care for HCV treatment"<br>
DOI: 10.6084/m9.figshare.12213320
title: A global analysis of anthropogenic development of marine turtle nesting beaches

description: Raw dataset for "Biddiscombe et al. (In Review April 2020) A global analysis of anthropogenic development of marine turtle nesting beaches. Remote Sensing 757969".<br>The file is a .csv file that details 16,009 survey points at which hard anthropogenic coastal development was scored into five bins (0, 25, 50, 75 and 100% coverage), and marine turtle nesting abundance and species data appended.
DOI: 10.6084/m9.figshare.12213188
title: Full-length transcriptome sequencing from multiple immune-related tissues of Paralichthys olivaceus

description: The mRNA-miRNA interacting networks construction results of Paralichthys olivaceus were deposited in this dataset.
DOI: 10.6084/m9.figshare.12213188.v1
title: Full-length transcriptome sequencing from multiple immune-related tissues of Paralichthys olivaceus

description: The mRNA-miRNA interacting networks construction results of Paralichthys olivaceus were deposited in this dataset.
DOI: 10.21954/ou.rd.12213146
title: Security Between Us

description: This is a modelling activity for pairs. It relates different views of real-world security incidents to participants' own values and experiences. Teams can use this workshop to identify security practices that work well in their environment, and to point out areas that can be improved.
DOI: 10.21954/ou.rd.12213137
title: Security and Me

description: A self-assessment tool that prompts reflection and discussion about individual attitudes toward security. This inventory helps developers and teams develop their sense of why security is important.
DOI: 10.6084/m9.figshare.12213119
title: Supplementary Material for: Histopathological Revision for Gastroenteropancreatic Neuroendocrine Neoplasms in Expert Centers: Does It Make the Difference?

description: <b><i>Background:</i></b> The correct histopathological diagnosis of gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) is crucial for treatment selection and prognostication. It is also very challenging due to limited experience in nonexpert centers. Revision of pathology is standard of care for most patients who are referred to NEN expert centers. <b><i>Objectives:</i></b> To describe the clinical impact of histopathological revision for GEP-NEN patients referred to an expert center. <b><i>Methods:</i></b> Retrospective multicenter analysis of all GEP-NENs receiving a histopathological revision in 6 European NEN expert centers (January 2016 to December 2016) to evaluate the impact on patient management. <b><i>Results:</i></b> 175 patients were included and 14.7% referred for a second opinion. Histological samples were 69.1% biopsies, 23.4% surgical specimens, and 7.5% endoscopic resections. Histopathological changes due to revision included first assessment of Ki67 in 8.6% of cases, change in grading in 11.4% (3.4% G1 to G2; 5.7% G2 to G1; 0.6% G2 to G3; 1.7% G3 to G2), definition of tumor invasion in 10.8%, additional immunohistochemical staining in 2.3%, diagnosis of mixed adenoneuroendocrine carcinoma in 3.4%, exclusion of NEN in 3.4%, first diagnosis of NEN in 2.3%, and tumor differentiation for G3 in 1.7%. The revision had a clinical impact in 36.0% of patients, leading to a new therapeutic indication in 26.3%. The indication to then perform a new imaging test occurred in 21.1% and recommendation to follow-up with no further treatment in 6.3%. <b><i>Conclusions:</i></b> Histopathological revision in expert centers for NENs can change the diagnosis, with a significant clinical impact in about one third of patients.
DOI: 10.21954/ou.rd.12213146.v1
title: Security Between Us

description: This is a modelling activity for pairs. It relates different views of real-world security incidents to participants' own values and experiences. Teams can use this workshop to identify security practices that work well in their environment, and to point out areas that can be improved.
DOI: 10.21954/ou.rd.12213113
title: Security in the Community

description: A how-to guide that helps developers bolster their security know-how online, with tips about how-to get involved - by engaging with real problems, and giving and receiving support from other developers. <br>
DOI: 10.6084/m9.figshare.12213056
title: Supplementary Material for: Dynamic-Ventilatory Digital Radiography in Air Flow Limitation: A Change in Lung Area Reflects Air Trapping

description: <b><i>Objective:</i></b> The aim of this study was to determine the utility of dynamic-ventilatory digital radiography (DR) for pulmonary function assessment in patients with airflow limitation. <b><i>Methods:</i></b> One hundred and eighteen patients with airflow limitation (72 patients with lung cancer before surgery, 35 patients with chronic obstructive pulmonary disease [COPD], 6 patients with asthma, and 5 patients with asthma-COPD overlap syndrome) were assessed with dynamic-ventilatory DR. The patients were instructed to inhale and exhale slowly and maximally. Sequential chest X-ray images were captured in 15 frames per second using a dynamic flat-panel imaging system. The relationship between the lung area and the rate of change in the lung area due to respiratory motion with respect to pulmonary function was analyzed. <b><i>Results:</i></b> The rate of change in the lung area from maximum inspiration to maximum expiration (Rs ratio) was associated with the RV/TLC ratio (<i>r</i> = 0.48, <i>p</i> &lt; 0.01) and the percentage of the predicted FEV<sub>1</sub> (<i>r</i> = –0.33, <i>p</i> &lt; 0.01) in patients with airflow limitations. The Rs ratio also decreased in an FEV<sub>1</sub>-dependent manner. <b><i>Conclusion:</i></b> The rate of change in the lung area due to respiratory motion evaluated with dynamic DR reflects air trapping. Dynamic DR is a potential tool for the comprehensive assessment of pulmonary function in patients with COPD.
DOI: 10.6084/m9.figshare.12213110
title: Supplementary Material for: Tranexamic Acid Protects Ovary and Testis Functions and Ameliorates Osteoporosis in Mice

description: <b><i>Introduction:</i></b> In a rapidly aging society, the number of people suffering from osteoporosis keeps increasing. However, effective prevention strategies for osteoporosis are not yet currently available. <b><i>Objective:</i></b> In this study, we examined the ameliorative effects of tranexamic acid on osteoporosis in 24-month-old mice. <b><i>Methods:</i></b> During the study period, mice were orally administered tranexamic acid 3 times per week. <b><i>Results:</i></b> Bone mineral density, which is a parameter of osteoporosis, was improved following tranexamic acid administration. In addition, female mice evidenced a stronger phenotypic improvement than male mice. In female mice treated with tranexamic acid, ovary abnormalities were reduced. Furthermore, the levels of transforming growth factor-β, hyaluronic acid, CD44, reactive oxygen species, and apoptosis, as well as the number of infiltrated neutrophils and macrophages in the ovary were lower than those in the control or solvent-administered mice. In addition, 17β-estradiol levels in blood increased when compared with the control or solvent-treated mice. In addition, administration of tranexamic acid to 24-month-old male mice decreased the level of apoptosis in the testis. However, the levels of 17β-estradiol and testosterone in blood increased compared with the control or solvent-administered mice. <b><i>Conclusions:</i></b> The use of tranexamic acid had an ameliorative effect on osteoporosis, possibly by protecting ovaries and testes.
DOI: 10.6084/m9.figshare.12213119.v1
title: Supplementary Material for: Histopathological Revision for Gastroenteropancreatic Neuroendocrine Neoplasms in Expert Centers: Does It Make the Difference?

description: <b><i>Background:</i></b> The correct histopathological diagnosis of gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) is crucial for treatment selection and prognostication. It is also very challenging due to limited experience in nonexpert centers. Revision of pathology is standard of care for most patients who are referred to NEN expert centers. <b><i>Objectives:</i></b> To describe the clinical impact of histopathological revision for GEP-NEN patients referred to an expert center. <b><i>Methods:</i></b> Retrospective multicenter analysis of all GEP-NENs receiving a histopathological revision in 6 European NEN expert centers (January 2016 to December 2016) to evaluate the impact on patient management. <b><i>Results:</i></b> 175 patients were included and 14.7% referred for a second opinion. Histological samples were 69.1% biopsies, 23.4% surgical specimens, and 7.5% endoscopic resections. Histopathological changes due to revision included first assessment of Ki67 in 8.6% of cases, change in grading in 11.4% (3.4% G1 to G2; 5.7% G2 to G1; 0.6% G2 to G3; 1.7% G3 to G2), definition of tumor invasion in 10.8%, additional immunohistochemical staining in 2.3%, diagnosis of mixed adenoneuroendocrine carcinoma in 3.4%, exclusion of NEN in 3.4%, first diagnosis of NEN in 2.3%, and tumor differentiation for G3 in 1.7%. The revision had a clinical impact in 36.0% of patients, leading to a new therapeutic indication in 26.3%. The indication to then perform a new imaging test occurred in 21.1% and recommendation to follow-up with no further treatment in 6.3%. <b><i>Conclusions:</i></b> Histopathological revision in expert centers for NENs can change the diagnosis, with a significant clinical impact in about one third of patients.
DOI: 10.6084/m9.figshare.12213056.v1
title: Supplementary Material for: Dynamic-Ventilatory Digital Radiography in Air Flow Limitation: A Change in Lung Area Reflects Air Trapping

description: <b><i>Objective:</i></b> The aim of this study was to determine the utility of dynamic-ventilatory digital radiography (DR) for pulmonary function assessment in patients with airflow limitation. <b><i>Methods:</i></b> One hundred and eighteen patients with airflow limitation (72 patients with lung cancer before surgery, 35 patients with chronic obstructive pulmonary disease [COPD], 6 patients with asthma, and 5 patients with asthma-COPD overlap syndrome) were assessed with dynamic-ventilatory DR. The patients were instructed to inhale and exhale slowly and maximally. Sequential chest X-ray images were captured in 15 frames per second using a dynamic flat-panel imaging system. The relationship between the lung area and the rate of change in the lung area due to respiratory motion with respect to pulmonary function was analyzed. <b><i>Results:</i></b> The rate of change in the lung area from maximum inspiration to maximum expiration (Rs ratio) was associated with the RV/TLC ratio (<i>r</i> = 0.48, <i>p</i> &lt; 0.01) and the percentage of the predicted FEV<sub>1</sub> (<i>r</i> = –0.33, <i>p</i> &lt; 0.01) in patients with airflow limitations. The Rs ratio also decreased in an FEV<sub>1</sub>-dependent manner. <b><i>Conclusion:</i></b> The rate of change in the lung area due to respiratory motion evaluated with dynamic DR reflects air trapping. Dynamic DR is a potential tool for the comprehensive assessment of pulmonary function in patients with COPD.
DOI: 10.6084/m9.figshare.12213017
title: S4 Data Extraction Table Turmeric VRolfe 3Apr2020 V2.xlsx

description: Same as previous entry with 3 typographical errors corrected.
DOI: 10.21954/ou.rd.12213113.v1
title: Security in the Community

description: A how-to guide that helps developers bolster their security know-how online, with tips about how-to get involved - by engaging with real problems, and giving and receiving support from other developers. <br>
DOI: 10.6084/m9.figshare.12213017.v1
title: S4 Data Extraction Table Turmeric VRolfe 3Apr2020 V2.xlsx

description: Same as previous entry with 3 typographical errors corrected.
DOI: 10.6084/m9.figshare.12212855
title: Cytotoxicity profiles of multi-walled carbon nanotubes with different physico-chemical properties

description: Multi-walled carbon nanotubes (MWCNTs) have industrial applications in the nanotechnology field. The physico-chemical properties of MWCNTs vary greatly depending on MWCNT manufacture and application. It has been pointed out that their needle shape and high durability are important factors that determine the biopersistence of fibers and can lead to inhalation toxicity or cytotoxicity. In this study, we prepared six suspensions of MWCNTs differing in diameter and length, and performed <i>in vitro</i> cell-based assays for 24 h using NR8383 rat alveolar macrophages. Rigid, needle-shaped MWCNTs with a large diameter (&gt;50 µm) penetrated the cytoplasm and decreased cell survival without generating intracellular reactive oxygen species (ROS), significantly up-regulated many genes involved in inflammatory responses, response to oxidative stress and apoptosis, and extracellular matrix degradation. Bent MWCNTs with a small diameter (&lt;20 µm) were phagocytosed in vacuole-like cellular compartments and decreased cell survival along with intracellular ROS generation. Straight, thin MWCNTs with a small diameter (&lt;20 µm) caused a slight intracellular ROS generation but no decrease in cell viability. Some straight, long, and thin MWCNTs were found in the mitochondria and near the nuclei; however, no mutagenesis was observed. The <i>in vitro</i> cell-based assays showed high cytotoxicity of MWCNTs with a large diameter (&gt;50 µm), moderate and low cytotoxicity of MWCNTs with a small diameter (&lt;20 µm). These results suggested that the diameter of MWCNTs considerably contributes to their cytotoxicity.
DOI: 10.6084/m9.figshare.12212642
title: Actein LCMS.xls

description: To determine whether actein could penetrate through BBB, an Agilent 1290 UHPLC with 6530 QTOF LC/MS/MS system (CA, USA) was used, with an Agilent ZORBAX Eclipse Plus C18 RRHD (1.8 μm, 2.1 × 150 mm) column.
DOI: 10.6084/m9.figshare.12212654
title: Supplementary Material for: Cavernous Malformation Hemorrhagic Presentation at Diagnosis Associated with Low 25-Hydroxy-Vitamin D Level

description: <b><i>Background:</i></b> Cavernous malformations (CM) are angiographically occult vascular malformations that may be incidental or present with intracerebral or spinal hemorrhage, seizures, or nonhemorrhagic focal neurologic deficit (FND). Recently in vitro data have suggested vitamin D may play a role in stabilizing CCM2 endothelial cells. Little is known about the effect of vitamin D in human CM disease. <b><i>Methods:</i></b> Beginning in 2015, consecutive patients at our institution with radiologically confirmed CM were recruited to participate in a prospective clinical registry as well as 25-hydroxy-vitamin D study. A structured interview, survey, and examination were performed at baseline. Medical records and magnetic resonance imaging studies were reviewed and data collected included comorbid conditions, medication use, and location of CM. Standard definition of clinical hemorrhage, FND, and seizures was used. Univariate and multivariate logistic regression models were used, and OR, 95% CIs, and likelihood-ratio <i>p</i> values were calculated to determine the influence of the 25-hydroxy-vitamin D level on clinical presentation with hemorrhage. <b><i>Results:</i></b> Of 213 patients enrolled in the clinical registry between January 2015 and October 2018, 70 participated in the vitamin D study (median age: 38.3 years; 51.4% female). Of the 70 participants, 30 (42.9%) presented with hemorrhage. 25-Hydroxy-vitamin D levels were performed within 1 year of symptoms in 64.1% of patients. Patients presenting with hemorrhage had a lower 25-hydroxy-vitamin D level compared to those presenting with seizure without hemorrhage, FND, or as an incidental finding (median 25.5 ng/mL; range 11–59 hemorrhage vs. median 31.0; range 14–60, no hemorrhage; <i>p</i> = 0.04). After adjusting for age, month of blood draw, and body mass index, 25-hydroxy-vitamin D remained a significant predictor of hemorrhagic presentation. Brainstem location also predicted hemorrhage at presentation. <b><i>Conclusion:</i></b> Low 25-hydroxy-vitamin D level was more common in patients with CM presenting with hemorrhage. This study supports the potential role of modifiable factor in the initial clinical presentation of CM. Further study is needed to determine the role of vitamin D on prospective hemorrhage risk and whether supplementation may be beneficial.
DOI: 10.6084/m9.figshare.12212855.v2
title: Cytotoxicity profiles of multi-walled carbon nanotubes with different physico-chemical properties

description: Multi-walled carbon nanotubes (MWCNTs) have industrial applications in the nanotechnology field. The physico-chemical properties of MWCNTs vary greatly depending on MWCNT manufacture and application. It has been pointed out that their needle shape and high durability are important factors that determine the biopersistence of fibers and can lead to inhalation toxicity or cytotoxicity. In this study, we prepared six suspensions of MWCNTs differing in diameter and length, and performed <i>in vitro</i> cell-based assays for 24 h using NR8383 rat alveolar macrophages. Rigid, needle-shaped MWCNTs with a large diameter (&gt;50 µm) penetrated the cytoplasm and decreased cell survival without generating intracellular reactive oxygen species (ROS), significantly up-regulated many genes involved in inflammatory responses, response to oxidative stress and apoptosis, and extracellular matrix degradation. Bent MWCNTs with a small diameter (&lt;20 µm) were phagocytosed in vacuole-like cellular compartments and decreased cell survival along with intracellular ROS generation. Straight, thin MWCNTs with a small diameter (&lt;20 µm) caused a slight intracellular ROS generation but no decrease in cell viability. Some straight, long, and thin MWCNTs were found in the mitochondria and near the nuclei; however, no mutagenesis was observed. The <i>in vitro</i> cell-based assays showed high cytotoxicity of MWCNTs with a large diameter (&gt;50 µm), moderate and low cytotoxicity of MWCNTs with a small diameter (&lt;20 µm). These results suggested that the diameter of MWCNTs considerably contributes to their cytotoxicity.
DOI: 10.6084/m9.figshare.12212654.v1
title: Supplementary Material for: Cavernous Malformation Hemorrhagic Presentation at Diagnosis Associated with Low 25-Hydroxy-Vitamin D Level

description: <b><i>Background:</i></b> Cavernous malformations (CM) are angiographically occult vascular malformations that may be incidental or present with intracerebral or spinal hemorrhage, seizures, or nonhemorrhagic focal neurologic deficit (FND). Recently in vitro data have suggested vitamin D may play a role in stabilizing CCM2 endothelial cells. Little is known about the effect of vitamin D in human CM disease. <b><i>Methods:</i></b> Beginning in 2015, consecutive patients at our institution with radiologically confirmed CM were recruited to participate in a prospective clinical registry as well as 25-hydroxy-vitamin D study. A structured interview, survey, and examination were performed at baseline. Medical records and magnetic resonance imaging studies were reviewed and data collected included comorbid conditions, medication use, and location of CM. Standard definition of clinical hemorrhage, FND, and seizures was used. Univariate and multivariate logistic regression models were used, and OR, 95% CIs, and likelihood-ratio <i>p</i> values were calculated to determine the influence of the 25-hydroxy-vitamin D level on clinical presentation with hemorrhage. <b><i>Results:</i></b> Of 213 patients enrolled in the clinical registry between January 2015 and October 2018, 70 participated in the vitamin D study (median age: 38.3 years; 51.4% female). Of the 70 participants, 30 (42.9%) presented with hemorrhage. 25-Hydroxy-vitamin D levels were performed within 1 year of symptoms in 64.1% of patients. Patients presenting with hemorrhage had a lower 25-hydroxy-vitamin D level compared to those presenting with seizure without hemorrhage, FND, or as an incidental finding (median 25.5 ng/mL; range 11–59 hemorrhage vs. median 31.0; range 14–60, no hemorrhage; <i>p</i> = 0.04). After adjusting for age, month of blood draw, and body mass index, 25-hydroxy-vitamin D remained a significant predictor of hemorrhagic presentation. Brainstem location also predicted hemorrhage at presentation. <b><i>Conclusion:</i></b> Low 25-hydroxy-vitamin D level was more common in patients with CM presenting with hemorrhage. This study supports the potential role of modifiable factor in the initial clinical presentation of CM. Further study is needed to determine the role of vitamin D on prospective hemorrhage risk and whether supplementation may be beneficial.