cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.24941414.v1
title: Integration analysis of PLAUR as a sunitinib resistance and macrophage related biomarker in ccRCC, an in silicon and experimental study

description: Sunitinib remains the preferred systemic treatment option for specific patients with advanced RCC who are ineligible for immune therapy. However, it’s essential to recognize that Sunitinib fails to elicit a favourable response in all patients. Moreover, most patients eventually develop resistance to Sunitinib. Therefore, identifying new targets associated with Sunitinib resistance is crucial. Utilizing multiple datasets from public cohorts, we conducted an exhaustive analysis and identified a total of 8 microRNAs and 112 mRNAs displaying significant expression differences between Sunitinib responsive and resistant groups. A particular set of six genes, specifically NIPSNAP1, STK40, SDC4, NEU1, TBC1D9, and PLAUR, were identified as highly significant <i>via</i> WGCNA. To delve deeper into the resistance mechanisms, we performed additional investigations using cell, molecular, and flow cytometry tests. These studies confirmed PLAUR's pivotal role in fostering Sunitinib resistance, both <i>in vitro</i> and <i>in vivo</i>. Our findings suggest that PLAUR could be a promising therapeutic target across various cancer types. In conclusion, this investigation not only uncovers vital genes and microRNAs associated with Sunitinib resistance in RCC but also introduces PLAUR as a prospective therapeutic target for diverse cancers. The outcomes contribute to advancing personalized healthcare and developing superior therapeutic strategies.
DOI: 10.6084/m9.figshare.24975216
title: Antipyretic effects of Xiangqin Jiere granules on febrile young rats revealed by combining pharmacodynamics, metabolomics, network pharmacology, molecular biology experiments and molecular docking strategies

description: Xiangqin Jiere granules (XQJRG) is a proprietary Chinese medicine treating children’s colds and fevers, but its mechanism of action is unclear. The aim of this study was to explore the antipyretic mechanisms of XQJRG based on pharmacodynamics, non-targeted metabolomics, network pharmacology, molecular biology experiments, molecular docking, and molecular dynamics (MD) simulation. Firstly, the yeast-induced fever model was constructed in young rats to study antipyretic effect of XQJRG. Metabolomics and network pharmacology studies were performed to identify the key compounds, targets and pathways involved in the antipyretic of XQJRG. Subsequently, MetScape was used to jointly analyze targets from network pharmacology and metabolites from metabolomics. Finally, the key targets were validated by enzyme-linked immunosorbent assay (ELISA), and the affinity and stability of key ingredient and targets were evaluated by molecular docking and MD simulation. The animal experimental results showed that after XQJRG treatment, body temperature of febrile rats was significantly reduced, 13 metabolites were significantly modulated, and pathways of differential metabolite enrichment were mainly related to amino acid and lipid metabolism. Network pharmacology results indicated that quercetin and kaempferol were the key active components of XQJRG, <i>TNF</i>, <i>AKT1</i>, <i>IL6</i>, <i>IL1B</i> and <i>PTGS2</i> were core targets. ELISA confirmed that XQJRG significantly reduced the plasma concentrations of IL-1β, IL-6, and TNF-α, and the hypothalamic concentrations of COX-2 and PGE2. Molecular docking demonstrated that the binding energies of kaempferol to the core targets were all below −5.0 kcal/mol. MD simulation results showed that the binding free energies of TNF-kaempferol, IL6-kaempferol, IL1B-kaempferol and PTGS2-kaempferol were −87.86 kcal/mol, −70.41 kcal/mol, −69.95 kcal/mol and −106.67 kcal/mol, respectively. In conclusion, XQJRG has antipyretic effects on yeast-induced fever in young rats, and its antipyretic mechanisms may be related to the inhibition of peripheral pyrogenic cytokines release by constituents such as kaempferol, the reduction of hypothalamic fever mediator production, and the amelioration of disturbances in amino acid and lipid metabolism.
DOI: 10.6084/m9.figshare.24975216.v1
title: Antipyretic effects of Xiangqin Jiere granules on febrile young rats revealed by combining pharmacodynamics, metabolomics, network pharmacology, molecular biology experiments and molecular docking strategies

description: Xiangqin Jiere granules (XQJRG) is a proprietary Chinese medicine treating children’s colds and fevers, but its mechanism of action is unclear. The aim of this study was to explore the antipyretic mechanisms of XQJRG based on pharmacodynamics, non-targeted metabolomics, network pharmacology, molecular biology experiments, molecular docking, and molecular dynamics (MD) simulation. Firstly, the yeast-induced fever model was constructed in young rats to study antipyretic effect of XQJRG. Metabolomics and network pharmacology studies were performed to identify the key compounds, targets and pathways involved in the antipyretic of XQJRG. Subsequently, MetScape was used to jointly analyze targets from network pharmacology and metabolites from metabolomics. Finally, the key targets were validated by enzyme-linked immunosorbent assay (ELISA), and the affinity and stability of key ingredient and targets were evaluated by molecular docking and MD simulation. The animal experimental results showed that after XQJRG treatment, body temperature of febrile rats was significantly reduced, 13 metabolites were significantly modulated, and pathways of differential metabolite enrichment were mainly related to amino acid and lipid metabolism. Network pharmacology results indicated that quercetin and kaempferol were the key active components of XQJRG, <i>TNF</i>, <i>AKT1</i>, <i>IL6</i>, <i>IL1B</i> and <i>PTGS2</i> were core targets. ELISA confirmed that XQJRG significantly reduced the plasma concentrations of IL-1β, IL-6, and TNF-α, and the hypothalamic concentrations of COX-2 and PGE2. Molecular docking demonstrated that the binding energies of kaempferol to the core targets were all below −5.0 kcal/mol. MD simulation results showed that the binding free energies of TNF-kaempferol, IL6-kaempferol, IL1B-kaempferol and PTGS2-kaempferol were −87.86 kcal/mol, −70.41 kcal/mol, −69.95 kcal/mol and −106.67 kcal/mol, respectively. In conclusion, XQJRG has antipyretic effects on yeast-induced fever in young rats, and its antipyretic mechanisms may be related to the inhibition of peripheral pyrogenic cytokines release by constituents such as kaempferol, the reduction of hypothalamic fever mediator production, and the amelioration of disturbances in amino acid and lipid metabolism.
DOI: 10.5281/zenodo.15077302
title: Multi crystal in situ data set from VMXi at Diamond Light Source: bovine and human

description: In situ data set of cubic insulin data recorded on beamline VMXi at Diamond Light Source, shared to allow methods development and testing and comparison with similar cryo data sets also published.
DOI: 10.5281/zenodo.15077303
title: Multi crystal in situ data set from VMXi at Diamond Light Source: bovine and human

description: In situ data set of cubic insulin data recorded on beamline VMXi at Diamond Light Source, shared to allow methods development and testing and comparison with similar cryo data sets also published.
DOI: 10.15468/dl.95zg9n
title: Occurrence Download

description: A dataset containing 23 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Acacia muricata (L.) Willd.)",
 "HasCoordinate is true",
 "HasGeospatialIssue is false"
 ]
}

 The dataset includes 23 records from 9 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0025098-250310093411724/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.b3yg8p
title: Occurrence Download

description: A dataset containing 14 species occurrences available in GBIF matching the query:
{
 "and" : [
 "BasisOfRecord is Human Observation",
 "Country is Netherlands",
 "Month is one of (January, November, December)",
 "TaxonKey is Ardea alba Linnaeus, 1758",
 "Year 1980-1998"
 ]
}

 The dataset includes 14 records from 2 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0025099-250310093411724/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.eszwqv
title: Occurrence Download

description: A dataset containing 352 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Acacia neovernicosa Isely, Acacia neovernicosa Isley)",
 "HasCoordinate is true",
 "HasGeospatialIssue is false"
 ]
}

 The dataset includes 352 records from 33 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0025103-250310093411724/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.hvyj98
title: Occurrence Download

description: A dataset containing 14122 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Meles meles (Linnaeus, 1758)",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "Country is Switzerland",
 "Year is greater than or equal to 2000",
 "Year is less than or equal to 2010"
 ]
}

 The dataset includes 14122 records from 3 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0025102-250310093411724/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.25345/c5ww77c01
title: MassIVE MSV000097422 - Lipidomics Analysis of Akkermansia muciniphila OMVs.
title: This is lipidomics data from an Akkermansia muciniphila OMV extract, measured using an RP C8 column in ESI negative mode.
DOI: 10.15468/dl.ruf4a8
title: Occurrence Download

description: A dataset containing 181 species occurrences available in GBIF matching the query:
{
 "and" : [
 "BasisOfRecord is one of (Human Observation, Material sample, Specimen)",
 "TaxonKey is Eumops auripendulus (Shaw, 1800)",
 "Year 1970-2025"
 ]
}

 The dataset includes 181 records from 37 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0025105-250310093411724/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.qxrd92
title: Occurrence Download

description: A dataset containing 34840297 species occurrences available in GBIF matching the query:
{
 "Country" : [
 "is Mexico"
 ]
}

 The dataset includes 34840297 records from 3838 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0025071-250310093411724/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.tgj6s4
title: Occurrence Download

description: A dataset containing 3 species occurrences available in GBIF matching the query:
{
 "and" : [
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 "TaxonKey is Atractus franciscopaivai Silva Haad, 2004"
 ]
}

 The dataset includes 3 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0263601-230224095556074/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.h9xpyu
title: Occurrence Download

description: A dataset containing 273 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Anthephora elongata De Wild."
 ]
}

 The dataset includes 273 records from 29 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0007192-240229165702484/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.8dkvpd
title: Occurrence Download

description: A dataset containing 2869 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Geometry POLYGON((-117.82952 23.97889,-104.86889 23.42795,-105.15452 32.99129,-117.90093 33.0084,-117.82952 23.97889))",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 "TaxonKey is Myiopsitta monachus (Boddaert, 1783)"
 ]
}

 The dataset includes 2869 records from 5 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0263609-230224095556074/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.ftthhp
title: Occurrence Download

description: A dataset containing 32 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Microchirita elphinstonia (Craib) A.Weber & D.J.Middleton"
 ]
}

 The dataset includes 32 records from 15 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0039591-230530130749713/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.etq2ch
title: Occurrence Download

description: A dataset containing 1 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Masdevallia medinae Luer & J.Portilla"
 ]
}

 The dataset includes 1 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0020156-230530130749713/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.h8et9k
title: Occurrence Download

description: A dataset containing 1796 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Plantae",
 "HasGeospatialIssue is false",
 "HasCoordinate is true",
 "OccurrenceStatus is Present",
 "Country is Germany",
 "DecimalLongitude is greater than or equal to 8.31397254751584",
 "DecimalLongitude is less than 8.31703210070023",
 "DecimalLatitude is greater than or equal to 47.27011",
 "DecimalLatitude is less than or equal to 55.05864"
 ]
}

 The dataset includes 1796 records from 29 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0007201-240229165702484/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.trdwdf
title: Occurrence Download

description: A dataset containing 17 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Microchirita mollissima (Ridl.) A.Weber & D.J.Middleton"
 ]
}

 The dataset includes 17 records from 7 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0039601-230530130749713/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.4fs4en
title: Occurrence Download

description: A dataset containing 6 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Amorphophallus mildbraedii K.Krause"
 ]
}

 The dataset includes 6 records from 5 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0007203-240229165702484/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.z4bskt
title: Occurrence Download

description: A dataset containing 4150 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Acytolepis puspa (Horsfield, 1828)"
 ]
}

 The dataset includes 4150 records from 48 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0260928-230224095556074/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.wdjxbc
title: Occurrence Download

description: A dataset containing 36 species occurrences available in GBIF matching the query:
{
 "and" : [
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 "TaxonKey is Atractus latifrons (Günther, 1868)"
 ]
}

 The dataset includes 36 records from 11 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0263612-230224095556074/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.znbqux
title: Occurrence Download

description: A dataset containing 105 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Microchirita involucrata (Craib) Yin Z.Wang"
 ]
}

 The dataset includes 105 records from 14 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0039594-230530130749713/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.2edv86
title: Occurrence Download

description: A dataset containing 410 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is China",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "TaxonKey is Myriophyllum spicatum L."
 ]
}

 The dataset includes 410 records from 20 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0007206-240229165702484/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.t8845v
title: Occurrence Download

description: A dataset containing 1 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Masdevallia melina Königer & J.Meza"
 ]
}

 The dataset includes 1 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0020163-230530130749713/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.dzfqhd
title: Occurrence Download

description: A dataset containing 227 species occurrences available in GBIF matching the query:
{
 "and" : [
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 "TaxonKey is Atractus fuliginosus (Hallowell, 1845)"
 ]
}

 The dataset includes 227 records from 15 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0263602-230224095556074/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.r8jb7h
title: Occurrence Download

description: A dataset containing 130 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Brettus cingulatus Thorell, 1895"
 ]
}

 The dataset includes 130 records from 6 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0039622-230530130749713/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.pyedf3
title: Occurrence Download

description: A dataset containing 43 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Sonchus pinnatus Aiton",
 "HasCoordinate is true",
 "Continent is Europe",
 "HasGeospatialIssue is false",
 "Year is greater than or equal to 2000",
 "CoordinateUncertaintyInMeters is less than 10000"
 ]
}

 The dataset includes 43 records from 2 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0007214-240229165702484/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.bwxn7d
title: Occurrence Download

description: A dataset containing 301820 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Pinus pinaster Aiton",
 "HasGeospatialIssue is false",
 "HasCoordinate is true",
 "OccurrenceStatus is Present",
 {
 "not" : {
 "BasisOfRecord" : [
 "is one of (Fossil, Living Specimen)"
 ]
 }
 },
 "Year 1990-2020"
 ]
}

 The dataset includes 301820 records from 362 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0260909-230224095556074/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.bpfnjy
title: Occurrence Download

description: A dataset containing 12 species occurrences available in GBIF matching the query:
{
 "and" : [
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 "TaxonKey is Atractus multicinctus (Jan, 1865)"
 ]
}

 The dataset includes 12 records from 4 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0263626-230224095556074/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.f4297j
title: Occurrence Download

description: A dataset containing 363807 species occurrences available in GBIF matching the query:
{
 "and" : [
 "VerbatimScientificName is Piaya cayana",
 "BasisOfRecord is one of (Machine Observation, Human Observation)",
 "Year 2011-2021",
 "HasCoordinate is true",
 "OccurrenceStatus is Present",
 {
 "not" : {
 "BasisOfRecord" : [
 "is one of (Fossil, Living Specimen, Specimen, Material citation, Material sample)"
 ]
 }
 }
 ]
}

 The dataset includes 363807 records from 208 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0080132-230530130749713/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.mt3wjd
title: Occurrence Download

description: A dataset containing 77 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Aneilema neocaledonicum Schltr."
 ]
}

 The dataset includes 77 records from 14 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0007213-240229165702484/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.4hfshd
title: Occurrence Download

description: A dataset containing 624 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Quercus canariensis Willd.",
 "HasGeospatialIssue is false",
 "HasCoordinate is true",
 "OccurrenceStatus is Present",
 {
 "not" : {
 "BasisOfRecord" : [
 "is one of (Fossil, Living Specimen)"
 ]
 }
 },
 "Year 1990-2020"
 ]
}

 The dataset includes 624 records from 40 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0260929-230224095556074/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.2naxwe
title: Occurrence Download

description: A dataset containing 46 species occurrences available in GBIF matching the query:
{
 "and" : [
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 "TaxonKey is Atractus manizalesensis Prado, 1940"
 ]
}

 The dataset includes 46 records from 6 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0263621-230224095556074/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.hbxtdc
title: Occurrence Download

description: A dataset containing 42 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Microchirita rupestris (Ridl.) A.Weber & D.J.Middleton"
 ]
}

 The dataset includes 42 records from 9 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0039604-230530130749713/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.