cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.6007892.v1
title: THE USE OF POLYSACCHARIDES EXTRACTED FROM SEED OF Persea americana var. Hass ON THE SYNTHESIS OF ACRYLIC HYDROGELS

description: This paper reports the use of polysaccharides extracted from seed of Persea americana var. Hass in the synthesis of acrylic hydrogels. The effects of the chemical composition (acrylamide/acrylic acid), the concentration of crosslinking agent (glycerol diacrylate) and the type of initiation (redox, photoinitiation) of the hydrogels were evaluated with and without polysaccharides. Xerogels were characterized by FTIR spectroscopy, differential scanning calorimetry (DSC) and scanning electron microscopy (SEM), while for the swollen hydrogels the swelling kinetic and mechanical properties were evaluated. The kinetic parameters were obtained using the second order equation proposed by Schott, where it is reported that by increasing the concentration of the crosslinking agent, the degree of swelling is reduced because of the greater structural level. The increase of the amount of acrylamide and the amount of polysaccharides causes also a decrease in the swelling degree. The type of initiation also affected the hydrogels swelling kinetic, the photoinitiated hydrogels were the ones that captured less water. Moreover, the increasing of the glass transition temperature and the compression modulus with the crosslinking agent concentration and molar ratio AAm/AAc are observed for hydrogels with and without polysaccharides. The results demonstrate a successful incorporation of polysaccharides into the polymeric network.
DOI: 10.6084/m9.figshare.6007889
title: Two Novel Donepezil-Lipoic Acid Hybrids: Synthesis, Anticholinesterase and Antioxidant Activities and Theoretical Studies

description: Alzheimer disease (AD) is a complex disease related to multiple pathogenic mechanisms. A strategy to develop effective drugs is based on the so-called multi-target directed ligands (MTDL) by using hybrid compounds. So, in the present study, we have designed and synthesized two hybrids, containing the indanone-piperidine moiety of donepezil, a drug approved for the treatment of AD, and the lipoic acid scaffold, an antioxidant compound endowed with neuroprotective effects. One hybrid was synthesized in four steps with 42% global yield, and the other hybrid in six steps with 19% global yield. The latter hybrid displayed moderate inhibitory activity against human acetylcholinesterase (hAChE) and greater activity against human butyrylcholinesterases (hBuChE). The selectivity for hBuChE was further rationalized by theoretical study. Importantly, the second hybrid showed a good antioxidant activity, exhibiting better ability in scavenging 2,2-diphenyl-1-picrylhydrazyl (DPPH) radicals than lipoic acid.
DOI: 10.6084/m9.figshare.6007889.v1
title: Two Novel Donepezil-Lipoic Acid Hybrids: Synthesis, Anticholinesterase and Antioxidant Activities and Theoretical Studies

description: Alzheimer disease (AD) is a complex disease related to multiple pathogenic mechanisms. A strategy to develop effective drugs is based on the so-called multi-target directed ligands (MTDL) by using hybrid compounds. So, in the present study, we have designed and synthesized two hybrids, containing the indanone-piperidine moiety of donepezil, a drug approved for the treatment of AD, and the lipoic acid scaffold, an antioxidant compound endowed with neuroprotective effects. One hybrid was synthesized in four steps with 42% global yield, and the other hybrid in six steps with 19% global yield. The latter hybrid displayed moderate inhibitory activity against human acetylcholinesterase (hAChE) and greater activity against human butyrylcholinesterases (hBuChE). The selectivity for hBuChE was further rationalized by theoretical study. Importantly, the second hybrid showed a good antioxidant activity, exhibiting better ability in scavenging 2,2-diphenyl-1-picrylhydrazyl (DPPH) radicals than lipoic acid.
DOI: 10.6084/m9.figshare.6007886
title: Assessment of Process Parameters by Friction Surfacing on the Double Layer Deposition

description: The friction surfacing process of two deposited layers on two deposition surface conditions, i.e., a smooth interface and a rough interface, was investigated. The control parameter of the deposition process was the rod feed rate with the use of a conventional milling machine. Analyzes of the surface characterization and microstructural characterization along the produced deposits were performed. The interface strength of the substrate/deposit1 (smooth) and deposit1/deposit2 (rough) was evaluated by bending tests and the micro-hardness profile along the transverse section of the substrate/deposit1 and deposit1/deposit2. The bending tests revealed the presence of smalls delaminations with no evidence of fracture at the rough deposit1/deposit2 interface (D1/D2) with less predominance in the deposition condition 3B. This suggests that the combination of the travel speed of 5.5 mm/s and an increase in the consumable rod feed rate of (≥5.5 mm/s) increases the adhesive strength of the two produced interfaces.
DOI: 10.6084/m9.figshare.6007886.v1
title: Assessment of Process Parameters by Friction Surfacing on the Double Layer Deposition

description: The friction surfacing process of two deposited layers on two deposition surface conditions, i.e., a smooth interface and a rough interface, was investigated. The control parameter of the deposition process was the rod feed rate with the use of a conventional milling machine. Analyzes of the surface characterization and microstructural characterization along the produced deposits were performed. The interface strength of the substrate/deposit1 (smooth) and deposit1/deposit2 (rough) was evaluated by bending tests and the micro-hardness profile along the transverse section of the substrate/deposit1 and deposit1/deposit2. The bending tests revealed the presence of smalls delaminations with no evidence of fracture at the rough deposit1/deposit2 interface (D1/D2) with less predominance in the deposition condition 3B. This suggests that the combination of the travel speed of 5.5 mm/s and an increase in the consumable rod feed rate of (≥5.5 mm/s) increases the adhesive strength of the two produced interfaces.
DOI: 10.6084/m9.figshare.6007883
title: COMMUNITY HEALTH AGENTS AND THE COMPLEXITIES OF THE WORKING WITH PATIENTS USING MEDICINES

description: Abstract The community health agents are an important element in the management of medication information in primary healthcare setting, improving healthcare team interaction with the community. The aim of this study was to reveal how the use of medicines is present in the routine of agentes and understand the relationships established between agents, users and healthcare team. This is a quantitative and qualitative study, using participant observation, semi-structured interview and focus group. This study was conducted at three basic health units in a municipality of Minas Gerais, Brazil, between March, 2013 and February, 2015. The results show that agents constantly relate with patients who experience drug therapy problems and have doubts about the indication, effects, adverse drug reactions, among other. They perform some interventions directly with the patient, but usually they prefer to refer cases to the healthcare team. Some agents said recognizing the pharmacist as a reference on medicines, but the demand for this professional was low by the subjects of this study. We emphasize the importance of the agents training on medication use to instrumentalize them to recognize problematic situations, to develop interventions with the support of the healthcare team and to follow up patients using medicines.
DOI: 10.6084/m9.figshare.6007880
title: Microstructure and Flight Behaviors of Droplet and its Solidification in Twin-Wire Arc Sprayed Ni-Al Composite Coatings

description: Droplet flight and solidification behaviors during twin-wire arc sprayed (TWAS) composite coatings were systematically investigated. Both theoretical model and numerical method were established for calculating the droplet deformation, breakup and solidification process in air flow based on the volume of fluid (VOF) dual-phase flow model jointed with the standard k-ε model. The experimental simulation results indicate that TWAS droplet is broken through explosion or two steps breaking process. The calculation of TWAS gas flight dynamics demonstrates that the TWAS particles are accelerated at first and then slowed down. Microstructure of the TWAS prepared Ni-5wt.%Al and Ni-20wt.%Al composite coating was accordingly characterized by XRD, SEM and TEM, so the phase compositions of the Ni-Al composite coatings were obtained. TEM analysis also showed that an amorphous phase was formed according to the characteristic of diffraction ring in Ni matrix solid solution at an original state.
DOI: 10.6084/m9.figshare.6007883.v1
title: COMMUNITY HEALTH AGENTS AND THE COMPLEXITIES OF THE WORKING WITH PATIENTS USING MEDICINES

description: Abstract The community health agents are an important element in the management of medication information in primary healthcare setting, improving healthcare team interaction with the community. The aim of this study was to reveal how the use of medicines is present in the routine of agentes and understand the relationships established between agents, users and healthcare team. This is a quantitative and qualitative study, using participant observation, semi-structured interview and focus group. This study was conducted at three basic health units in a municipality of Minas Gerais, Brazil, between March, 2013 and February, 2015. The results show that agents constantly relate with patients who experience drug therapy problems and have doubts about the indication, effects, adverse drug reactions, among other. They perform some interventions directly with the patient, but usually they prefer to refer cases to the healthcare team. Some agents said recognizing the pharmacist as a reference on medicines, but the demand for this professional was low by the subjects of this study. We emphasize the importance of the agents training on medication use to instrumentalize them to recognize problematic situations, to develop interventions with the support of the healthcare team and to follow up patients using medicines.
DOI: 10.6084/m9.figshare.6007880.v1
title: Microstructure and Flight Behaviors of Droplet and its Solidification in Twin-Wire Arc Sprayed Ni-Al Composite Coatings

description: Droplet flight and solidification behaviors during twin-wire arc sprayed (TWAS) composite coatings were systematically investigated. Both theoretical model and numerical method were established for calculating the droplet deformation, breakup and solidification process in air flow based on the volume of fluid (VOF) dual-phase flow model jointed with the standard k-ε model. The experimental simulation results indicate that TWAS droplet is broken through explosion or two steps breaking process. The calculation of TWAS gas flight dynamics demonstrates that the TWAS particles are accelerated at first and then slowed down. Microstructure of the TWAS prepared Ni-5wt.%Al and Ni-20wt.%Al composite coating was accordingly characterized by XRD, SEM and TEM, so the phase compositions of the Ni-Al composite coatings were obtained. TEM analysis also showed that an amorphous phase was formed according to the characteristic of diffraction ring in Ni matrix solid solution at an original state.
DOI: 10.6084/m9.figshare.6007874
title: THE TRAINING OF COMMUNITY HEALTH AGENTS AND CONSTRUCTION FROM THE MEETING OF THE SUBJECTS

description: Abstract This article presents a synthesis of observations developed in a research that had as objective to elaborate a pedagogical project to qualify the community health agents in health surveillance of the worker based on the perception of the subjects themselves. It was a qualitative study carried out in 2016, in Vitória da Conquista, Bahia, Brazil, which used the theoretical reference of action research and the focus group technique to approach the subjects. The first stage of the results exposes the view of the nurses regarding the qualification of the agents in health surveillance of the worker, and the second describes the participation and the perception of the community health agents in the construction of the pedagogical proposal of training. The nurses recommended that the training in health surveillance of the worker be built based on the assumptions of permanent education and showed interest in participating in this educational process. There was unanimity of the participating agents regarding the need for training. They suggested contents, methodology and didactic material for the construction of the pedagogical proposal, expressing the desire to participate in an educational process able to overcome the barriers of training, as a true process of permanent education in health.
DOI: 10.6084/m9.figshare.6007874.v1
title: THE TRAINING OF COMMUNITY HEALTH AGENTS AND CONSTRUCTION FROM THE MEETING OF THE SUBJECTS

description: Abstract This article presents a synthesis of observations developed in a research that had as objective to elaborate a pedagogical project to qualify the community health agents in health surveillance of the worker based on the perception of the subjects themselves. It was a qualitative study carried out in 2016, in Vitória da Conquista, Bahia, Brazil, which used the theoretical reference of action research and the focus group technique to approach the subjects. The first stage of the results exposes the view of the nurses regarding the qualification of the agents in health surveillance of the worker, and the second describes the participation and the perception of the community health agents in the construction of the pedagogical proposal of training. The nurses recommended that the training in health surveillance of the worker be built based on the assumptions of permanent education and showed interest in participating in this educational process. There was unanimity of the participating agents regarding the need for training. They suggested contents, methodology and didactic material for the construction of the pedagogical proposal, expressing the desire to participate in an educational process able to overcome the barriers of training, as a true process of permanent education in health.
DOI: 10.6084/m9.figshare.6007871
title: COMMUNITY OF PRACTICE AND MENTAL HEALTH CARE: A SYSTEMATIC REVISION

description: Abstract Mental health care is dependent on qualified human resources to respond dynamically to the service users’ needs. This qualification by reflection on the work processes is essential for effective change to a community and biopsychosocial perspective. The Community of Practice is a theoretical framework that fosters collaborative learning through mutual engagement in common projects and negotiation of meanings. The research had as objective to systematize the use of Community of Practice for improving mental health care, by systematic review at Capes Portal and Virtual Health Library in March 2015. We found nineteen articles and nine of them were selected for analysis. The studies evaluated the Community of Practice as positive to improve the services offered to the population, provide training from experts, and implement new methods of work. They highlight weaknesses (financial resources, initial misalignment between the participants, group conflicts) and potentialities (real engagement of participants, virtual participation, access to specialists, integration of professionals, users and families in a single project; training needs in context). We expected to clarify possibilities for training and investigative strategies for continuing education in mental health.
DOI: 10.6084/m9.figshare.6007871.v1
title: COMMUNITY OF PRACTICE AND MENTAL HEALTH CARE: A SYSTEMATIC REVISION

description: Abstract Mental health care is dependent on qualified human resources to respond dynamically to the service users’ needs. This qualification by reflection on the work processes is essential for effective change to a community and biopsychosocial perspective. The Community of Practice is a theoretical framework that fosters collaborative learning through mutual engagement in common projects and negotiation of meanings. The research had as objective to systematize the use of Community of Practice for improving mental health care, by systematic review at Capes Portal and Virtual Health Library in March 2015. We found nineteen articles and nine of them were selected for analysis. The studies evaluated the Community of Practice as positive to improve the services offered to the population, provide training from experts, and implement new methods of work. They highlight weaknesses (financial resources, initial misalignment between the participants, group conflicts) and potentialities (real engagement of participants, virtual participation, access to specialists, integration of professionals, users and families in a single project; training needs in context). We expected to clarify possibilities for training and investigative strategies for continuing education in mental health.
DOI: 10.6084/m9.figshare.6007868
title: STIGMA, INVISIBILITY AND WORK INTENSIFICATION: STRATEGIES TO COPE WITH SUFFERING BY ASSISTANTS IN ADMINISTRATION

description: Abstract TThis study aimed to analyze the experiences of pleasure-suffering of eight assistants in administration of a university that requested removal motivated by some dissatisfaction. The study, carried out between September of 2013 and August of 2015, was referenced in the Psychodynamics of Work. We chose semi-structured interviews and content analysis. Different aspects related to work emerged from three central categories: pleasure; suffering; defensive strategies and fight for recognition. Concerning suffering, the interviewees pointed out the stigma and invisibility of the middle activities, constant concern with conflicting aspects of work, somatization and work intensification. The experiences of pleasure were related to salary conditions, work qualification, symbolic retribution and possibilities of recognition. Faced with suffering, defensive strategies were highlighted in the fight for recognition: prioritizing qualification; verbalization of problems; and search for instruments of conflict protection, among others. In the expectation of minimizing dissatisfaction the interviewees used the removal that proved to be successful in part of the cases, helping them in the re-signification of work and preservation of health. This instrument, however, does not act in the origin of the experiences of pleasure-suffering. Suffering, besides being intrinsic to work, is situated in an organizational context that creates obstacles to the individual possibility of re-signifying it through removal.
DOI: 10.6084/m9.figshare.6007868.v1
title: STIGMA, INVISIBILITY AND WORK INTENSIFICATION: STRATEGIES TO COPE WITH SUFFERING BY ASSISTANTS IN ADMINISTRATION

description: Abstract TThis study aimed to analyze the experiences of pleasure-suffering of eight assistants in administration of a university that requested removal motivated by some dissatisfaction. The study, carried out between September of 2013 and August of 2015, was referenced in the Psychodynamics of Work. We chose semi-structured interviews and content analysis. Different aspects related to work emerged from three central categories: pleasure; suffering; defensive strategies and fight for recognition. Concerning suffering, the interviewees pointed out the stigma and invisibility of the middle activities, constant concern with conflicting aspects of work, somatization and work intensification. The experiences of pleasure were related to salary conditions, work qualification, symbolic retribution and possibilities of recognition. Faced with suffering, defensive strategies were highlighted in the fight for recognition: prioritizing qualification; verbalization of problems; and search for instruments of conflict protection, among others. In the expectation of minimizing dissatisfaction the interviewees used the removal that proved to be successful in part of the cases, helping them in the re-signification of work and preservation of health. This instrument, however, does not act in the origin of the experiences of pleasure-suffering. Suffering, besides being intrinsic to work, is situated in an organizational context that creates obstacles to the individual possibility of re-signifying it through removal.
DOI: 10.6084/m9.figshare.6007865
title: Heart Rate and its Variability Assessed by Spectral Analysis in Elderly Subjects with Orthostatic Hypotension: A Case-Control Study

description: Abstract Background: The prevalence of orthostatic hypotension (OH) increases with age and is associated with changes in autonomic regulation of blood pressure (BP) and heart rate (HR). Objective: to assess HR and HR variability (HRV) in elderly subjects with OH and determine OH predictors. Methods: a total of 105 patients aged ≥ 60 years, 39 with OH (case group) and 66 without OH (control group) (age-matched) were studied. Patients underwent clinical assessment, electrocardiogram, biochemistry tests and Holter monitoring for spectral analysis of HRV (Fourier transform) in the supine and orthostatism positions to identify low frequency (LF) and high frequency (HF) components, as well as the LF/HF ratio. Results: median age was 73.0 years, 64 patients were women. In all participants, there was a reduction in HF (133.0 versus 76.0 ms2, p = 0.001) and increase in LF/HF (1.6 vs 2.1; p &lt; 0.001) and no change in LF (233.0 versus 218.0 ms2, p = 0.080). Between-group comparisons revealed significant differences in the median values of HR in the supine position (62.0 vs. 69.0 bpm, p = 0.001) and LF in the supine position (157.0 in case group vs. 275.0 ms2 in the control group, p = 0.014). Spearman’s correlation coefficient of 0.27 was found between the groups. Multivariate analysis revealed that HR in the supine position was an independent variable for OH (p = 0.001- 95%CI = -0.022 and -0.006). Using the operating characteristic curve, the best cutoff point was 61 bpm, with a sensitivity of 77.3% and specificity of 51.3%, positive predictive value of 61.3%, and negative predictive value 69.3%. Odds ratio was 3.23 for OH in patients with a HR lower than 61 bpm. Conclusions: lower LF and HR in the supine position were found in patients with OH, regardless of age and gender. The independent predictor for OH was HR in the supine position, with an odds ratio of 3.23 for values lower than 61 bpm.