DOI: 10.7270/q2zc847x
title: BindingDB Entry 50042717: Discovery of a novel class of highly potent, selective, ATP-competitive, and orally bioavailable inhibitors of the mammalian target of rapamycin (mTOR).

description: Small molecule binding data for protein 5'-AMP-activated protein kinase subunit beta-1, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3), AKT/p21CIP1, ALK tyrosine kinase receptor, AXL receptor tyrosine kinase, Apoptosis Signal-regulating Kinase 1 (ASK1), BR serine/threonine-protein kinase 1, C-RAF, CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase), CaM kinase I alpha, CaM kinase IV, Casein kinase I isoform delta, Cyclin-Dependent Kinase 5 (CDK5), DNA-dependent protein kinase, Death-associated protein kinase 2, Death-associated protein kinase 3, Discoidin domain-containing receptor 2, Dual specificity mitogen-activated protein kinase kinase 1, Dual specificity mitogen-activated protein kinase kinase 4, Dual specificity mitogen-activated protein kinase kinase 6, Dual specificity mitogen-activated protein kinase kinase 7 (MAP2K7), Dual specificity protein kinase CLK2, Dual-specificity tyrosine-phosphorylation regulated kinase 2, EPHB1, Ephrin receptor, Epidermal growth factor receptor, Epidermal growth factor receptor and ErbB2 (HER1 and HER2), Fibroblast growth factor receptor 1, Fibroblast growth factor receptor 2, Fibroblast growth factor receptor 3, Fibroblast growth factor receptor 4, Focal adhesion kinase 1/vascular endothelial growth factor receptor 3, G protein-coupled receptor kinase 5, Glycogen synthase kinase-3, HSP90 and hnRNPA2/B1, Hepatocyte growth factor receptor, Homeodomain-interacting protein kinase 2 (HIPK2), IKK epsilon/TBK1, Inhibitor of NF-kappa-B kinase (IKK), Insulin-like growth factor I receptor, Interleukin-1 receptor-associated kinase 1, Kinesin-1 heavy chain/ Tyrosine-protein kinase receptor RET, LIM domain kinase 1, MAP kinase ERK2, MAP kinase signal-integrating kinase 2, MAP kinase-activated protein kinase 2, MAP kinase-activated protein kinase 3, MAP kinase-activated protein kinase 5, MER intracellular domain/EGFR extracellular domain chimera, Misshapen-like kinase 1, Mitogen-activated protein kinase 10, Mitogen-activated protein kinase 2, Mitogen-activated protein kinase kinase kinase 9 (MLK1), Muscle, skeletal receptor tyrosine protein kinase, Nuclear receptor subfamily 2 group C member 2, PAS domain-containing serine/threonine-protein kinase, PI3-kinase subunit alpha, PI3-kinase subunit beta, PI3-kinase subunit delta, PI3-kinase subunit gamma, PKC alpha and beta-2, PTK2B protein tyrosine kinase 2 beta (PTK2B), Phosphatidylinositol 3-kinase catalytic subunit type 3, Platelet-derived growth factor receptor beta, Protein kinase C (PKC), Protein kinase C alpha type, Protein kinase C delta type, Protein kinase C iota (PKCι), Protein kinase C theta type, Protein kinase C, epsilon, Protein kinase C, eta, Protein kinase C, gamma, Protein kinase N2, Proto-oncogene tyrosine-protein kinase ROS, Pyruvate dehydrogenase kinase isoenzyme 1 (PDK1), Rho-associated protein kinase, Ribosomal protein S6 kinase (P70S6K), Ribosomal protein S6 kinase alpha 1, Ribosomal protein S6 kinase alpha 2, Ribosomal protein S6 kinase alpha 3, Ribosomal protein S6 kinase alpha 5, Ribosomal protein S6 kinase alpha 6, SRC, Serine/threonine protein kinase NLK, Serine/threonine-protein kinase 10, Serine/threonine-protein kinase 11, Serine/threonine-protein kinase 33, Serine/threonine-protein kinase 4 (STK4), Serine/threonine-protein kinase AKT, Serine/threonine-protein kinase Aurora, Serine/threonine-protein kinase CHK2, Serine/threonine-protein kinase Chk1, Serine/threonine-protein kinase D1, Serine/threonine-protein kinase D2 (PKD2), Serine/threonine-protein kinase MARK1, Serine/threonine-protein kinase NEK7, Serine/threonine-protein kinase Nek2, Serine/threonine-protein kinase PAK6, Serine/threonine-protein kinase PIM, Serine/threonine-protein kinase PLK1, Serine/threonine-protein kinase PLK3, Serine/threonine-protein kinase RIPK2, Serine/threonine-protein kinase SRPK3, Serine/threonine-protein kinase Sgk1, Serine/threonine-protein kinase Sgk2, Serine/threonine-protein kinase Sgk3, Serine/threonine-protein kinase TAO1, Serine/threonine-protein kinase ULK2, Serine/threonine-protein kinase VRK2, Serine/threonine-protein kinase WNK2, Serine/threonine-protein kinase haspin, Testis-specific serine/threonine-protein kinase 1, Tyrosine kinase non-receptor protein 2, Tyrosine-protein kinase ABL, Tyrosine-protein kinase ABL1, Tyrosine-protein kinase BRK, Tyrosine-protein kinase Blk, Tyrosine-protein kinase CSK, Tyrosine-protein kinase Fes/Fps, Tyrosine-protein kinase ITK/TSK, Tyrosine-protein kinase JAK2, Tyrosine-protein kinase Kit (Kit), Tyrosine-protein kinase Yes, Tyrosine-protein kinase ZAP-70, Tyrosine-protein kinase receptor FLT3, Tyrosine-protein kinase receptor TYRO3, VEGF-receptor 2 and tyrosine-protein kinase SRC, Vascular endothelial growth factor receptor, Vascular endothelial growth factor receptor 2, c-Jun N-terminal kinase, JNK, cGMP-dependent protein kinase, and p21-Activated kinase 3 (PAK3), Uniprot L7RSL3, O00141, O00311, O00329, O14733, O14757, O14920, O14965, O15111, O15146, O43293, O43353, O60674, O75116, O75582, O75914, O94804, O96017, P00519, P00533, P04049, P04626, P05129, P05771, P07332, P07947, P07948, P07949, P08069, P08238, P08581, P08631, P08922, P09619, P10721, P11309, P11362, P12931, P17252, P17948, P21802, P22455, P22607, P23443, P24723, P28482, P29317, P30530, P31749, P31751, P34947, P35968, P36888, P41240, P41743, P42336, P42338, P42684, P43403, P45983, P45985, P48730, P48736, P49116, P49137, P49760, P49840, P49841, P51451, P51617, P51812, P51955, P52564, P53350, P53667, P53779, P54762, P78527, P80192, Q00535, Q02156, Q02750, Q04759, Q05397, Q05513, Q05655, Q06418, Q07912, Q08881, Q12851, Q12866, Q13043, Q13464, Q13882, Q13976, Q14012, Q14289, Q15078, Q15118, Q15139, Q15349, Q15418, Q15831, Q16513, Q16566, Q16644, Q16832, Q16875, Q7L7X3, Q86Y07, Q8IW41, Q8IYT8, Q8N4C8, Q8NEB9, Q8TDC3, Q8TDX7, Q8TF76, Q92630, Q96BR1, Q96RG2, Q99683, Q9BXA7, Q9BYT3, Q9BZL6, Q9H2X6, Q9H4B4, Q9HBH9, Q9HBY8, Q9NQU5, Q9P0L2, Q9UBE8, Q9UHD2, Q9UIK4, Q9UK32, Q9UM73, Q9UPE1, Q9Y243, Q9Y3S1, and Q9Y478