cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.10296209
title: Influence of interleukins on prognosis of patients with oral squamous cells carcinoma

description: ABSTRACT Squamous cell carcinoma is a malignant neoplasm that affects the structures and tissues of the oral cavity. Interleukins (IL) synthesized from a tumor modulate a cascade reaction that may influence the prognosis of the disease. We aim to investigate in the literature whether interleukins are mediators that negatively or positively influence the prognosis of patients with oral squamous cell carcinoma. A systematic review study was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyzes (PRISMA) instructions. PubMed (including MedLine), Scopus, Web of Science, SciELO and Latin American and Caribbean Health Sciences (LILACS) databases were used as the primary sources for the study; OpenGrey and OpenThesis were used to search for "gray literature". The search conducted in seven general databases resulted in a set of 858 studies, while the search conducted in two databases for gray literature resulted in 82 studies, totaling 940 studies. From these, 15 studies were selected for this systematic review (eight studies presented low bias risk; four studies presented moderate bias risk; and three studies presented high risk of bias). Although they may act on the anti-tumor immune response pathways, the IL evaluated in the present systematic review (IL-4, IL-6, IL-8, IL-10, IL-12 and IL-13) tend to present a response associated with the intensification of carcinogenesis and poor prognosis in patients with oral squamous cell carcinoma.
DOI: 10.6084/m9.figshare.10296215
title: Extreme root resorption in orthodontic practice: teeth do not have to be replaced with implants

description: ABSTRACT The replacement of natural teeth that have extreme external apical root resorption, induced by orthodontic treatment, with osseointegrated implants is not justifiable biologically or clinically. These teeth should be preserved and keep their normal functions, as there is no greater mobility, pain or color change. They may undergo usual procedures, such as bleaching, restorations with veneers and other esthetic procedures that may be necessary along life. The pulp of these teeth is normal. If mobility of a tooth with extreme resorption is identified, the cause of mobility should be investigated, as it is not associated with resorption, not even at advanced stages. Tooth mobility may be associated with recent removal of orthodontic appliance, occlusal trauma, chronic inflammatory periodontal disease, or even severe cervical bone loss. In such cases, the cause of mobility should be eliminated and possible sequelae should be corrected, because these, and not root resorption, may actually require retention.
DOI: 10.6084/m9.figshare.10296218
title: Styles and logics of territorial action. The recent experience of the municipalities of Paraguay

description: Abstract Territorial action is a complex process of development in which public, private, and collective actions intervene. As the Latin American experience shows, municipalities are increasingly important actors in building local development. They act in different ways, and this work highlights these differences in style and form of intervention. The study identifies four types or styles of action that synthesize two main elements. First, the forms of organization for obtaining resources. Second, the types of actions prioritized to build development processes and reduce problems of structural poverty.
DOI: 10.6084/m9.figshare.10296209.v1
title: Influence of interleukins on prognosis of patients with oral squamous cells carcinoma

description: ABSTRACT Squamous cell carcinoma is a malignant neoplasm that affects the structures and tissues of the oral cavity. Interleukins (IL) synthesized from a tumor modulate a cascade reaction that may influence the prognosis of the disease. We aim to investigate in the literature whether interleukins are mediators that negatively or positively influence the prognosis of patients with oral squamous cell carcinoma. A systematic review study was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyzes (PRISMA) instructions. PubMed (including MedLine), Scopus, Web of Science, SciELO and Latin American and Caribbean Health Sciences (LILACS) databases were used as the primary sources for the study; OpenGrey and OpenThesis were used to search for "gray literature". The search conducted in seven general databases resulted in a set of 858 studies, while the search conducted in two databases for gray literature resulted in 82 studies, totaling 940 studies. From these, 15 studies were selected for this systematic review (eight studies presented low bias risk; four studies presented moderate bias risk; and three studies presented high risk of bias). Although they may act on the anti-tumor immune response pathways, the IL evaluated in the present systematic review (IL-4, IL-6, IL-8, IL-10, IL-12 and IL-13) tend to present a response associated with the intensification of carcinogenesis and poor prognosis in patients with oral squamous cell carcinoma.
DOI: 10.6084/m9.figshare.10296218.v1
title: Styles and logics of territorial action. The recent experience of the municipalities of Paraguay

description: Abstract Territorial action is a complex process of development in which public, private, and collective actions intervene. As the Latin American experience shows, municipalities are increasingly important actors in building local development. They act in different ways, and this work highlights these differences in style and form of intervention. The study identifies four types or styles of action that synthesize two main elements. First, the forms of organization for obtaining resources. Second, the types of actions prioritized to build development processes and reduce problems of structural poverty.
DOI: 10.6084/m9.figshare.10296221.v1
title: AVOIDING INFINITE REGRESS: POSTERIOR ANALYTICS I 22

description: Abstract This article offers a reconstruction of an argument against infinite regress formulated by Aristotle in Posterior Analytics I 22. I argue against the traditional interpretation of the chapter, according to which singular terms and summa genera, in virtue of having restrict logical roles, provide limits for predicative chains, preventing them from proceeding ad infinitum. As I intend to show, this traditional reading is at odds with some important aspects of Aristotle’s theory of demonstration. More importantly, it fails to explain how his proof is connected to a defence of the existence of ultimate explanations, a connection that must be the case if I 19-22 is advancing a foundationalist way-out to a sceptical challenge raised in I 3.
DOI: 10.6084/m9.figshare.10296215.v1
title: Extreme root resorption in orthodontic practice: teeth do not have to be replaced with implants

description: ABSTRACT The replacement of natural teeth that have extreme external apical root resorption, induced by orthodontic treatment, with osseointegrated implants is not justifiable biologically or clinically. These teeth should be preserved and keep their normal functions, as there is no greater mobility, pain or color change. They may undergo usual procedures, such as bleaching, restorations with veneers and other esthetic procedures that may be necessary along life. The pulp of these teeth is normal. If mobility of a tooth with extreme resorption is identified, the cause of mobility should be investigated, as it is not associated with resorption, not even at advanced stages. Tooth mobility may be associated with recent removal of orthodontic appliance, occlusal trauma, chronic inflammatory periodontal disease, or even severe cervical bone loss. In such cases, the cause of mobility should be eliminated and possible sequelae should be corrected, because these, and not root resorption, may actually require retention.
DOI: 10.6084/m9.figshare.10296194
title: Histological evolution of fibrosis in patients with biliary atresia

description: ABSTRACT Objective: To evaluate the evolution of histological findings of patients with biliary atresia (BA), emphasizing the progression of fibrosis by comparing the diagnostic liver biopsy to the surgical liver biopsy, performed during Kasai portoenterostomy. Methods: Retrospective study with 51 patients with BA submitted to portoenterostomy, and both diagnostic (DLB) and surgical liver biopsies (SLB). The samples were blindly reviewed by two pathologists. Results: Median age at DLB and at SLB was 69 and 77 days, respectively. The median time between biopsies was eight days. Cirrhosis was more frequent in SLB than in DLB, both according to the Metavir score (p = 0.006) and the Ishak score (p = 0.016). The Metavir score increased one or more points in 29/51 (56.9%), with evidence of progression to liver cirrhosis in 11/29 (37.9%) of those who had progression of fibrosis. Median age at surgery of those who had a progression of fibrosis was 77 days, while in those 11 who progressed to cirrhosis, this median was 92 days. Cirrhosis was seen in 12/51 (23.5%) SLB patients. The clinical variable age at surgery had a statistically significant difference regarding the presence or absence of cirrhosis in SLB (p = 0.024). Cirrhosis was not related to survival with native liver or biliary drainage. Conclusion: Most infants with BA have liver fibrosis at diagnosis and it progresses rapidly. The presence of cirrhosis is correlated with the age at surgery, which suggests the importance of this clinical variable in the evolution of fibrosis.
DOI: 10.6084/m9.figshare.10296200
title: Dermatoscopy in polypoid basal-cell carcinoma: a rare histopathological variation

description: ABSTRACT Polypoid basal-cell carcinoma (BCC) is a rare tumor, considered a clinical and histopathological variant of the nodular BCC, presenting broad exophytic or pedunculated base that connects to the surface of the skin and histopathologically displays the neoplastic aggregations restricted to the polypoid zone. We report a clinical case of BCC, with a bibliographical review, highlighting the clinical similarity of such malignant tumor with other benign and malignant tumors of the skin, besides the importance of dermoscopy for the diagnostic aid.
DOI: 10.6084/m9.figshare.10296194.v1
title: Histological evolution of fibrosis in patients with biliary atresia

description: ABSTRACT Objective: To evaluate the evolution of histological findings of patients with biliary atresia (BA), emphasizing the progression of fibrosis by comparing the diagnostic liver biopsy to the surgical liver biopsy, performed during Kasai portoenterostomy. Methods: Retrospective study with 51 patients with BA submitted to portoenterostomy, and both diagnostic (DLB) and surgical liver biopsies (SLB). The samples were blindly reviewed by two pathologists. Results: Median age at DLB and at SLB was 69 and 77 days, respectively. The median time between biopsies was eight days. Cirrhosis was more frequent in SLB than in DLB, both according to the Metavir score (p = 0.006) and the Ishak score (p = 0.016). The Metavir score increased one or more points in 29/51 (56.9%), with evidence of progression to liver cirrhosis in 11/29 (37.9%) of those who had progression of fibrosis. Median age at surgery of those who had a progression of fibrosis was 77 days, while in those 11 who progressed to cirrhosis, this median was 92 days. Cirrhosis was seen in 12/51 (23.5%) SLB patients. The clinical variable age at surgery had a statistically significant difference regarding the presence or absence of cirrhosis in SLB (p = 0.024). Cirrhosis was not related to survival with native liver or biliary drainage. Conclusion: Most infants with BA have liver fibrosis at diagnosis and it progresses rapidly. The presence of cirrhosis is correlated with the age at surgery, which suggests the importance of this clinical variable in the evolution of fibrosis.
DOI: 10.6084/m9.figshare.10296200.v1
title: Dermatoscopy in polypoid basal-cell carcinoma: a rare histopathological variation

description: ABSTRACT Polypoid basal-cell carcinoma (BCC) is a rare tumor, considered a clinical and histopathological variant of the nodular BCC, presenting broad exophytic or pedunculated base that connects to the surface of the skin and histopathologically displays the neoplastic aggregations restricted to the polypoid zone. We report a clinical case of BCC, with a bibliographical review, highlighting the clinical similarity of such malignant tumor with other benign and malignant tumors of the skin, besides the importance of dermoscopy for the diagnostic aid.
DOI: 10.6084/m9.figshare.10296161
title: Comparison of the outcomes of laparoscopic pyeloplasty with and without concomitant pyelolithotomy

description: ABSTRACT Objective We aimed to evaluate the results of laparoscopic pyeloplasty with concomitant pyelolithotomy and compare results with a cohort of patients undergoing laparoscopic pyeloplasty without pyelolithotomy. Materials and Methods We retrospectively reviewed records of 43 patients undergoing transperitoneal laparoscopic Anderson-Hynes dismembered pyeloplasty between December 2012 and July 2018 at our department. Eighteen patients (42%) underwent laparoscopic pyeloplasty with concomitant pyelolithotomy. The results of patients with renal stones were compared with 25 matched patients undergoing laparoscopic pyeloplasty without concomitant renal stones. Demographic data, operative and stone parameters were compared between the groups. Results The groups were similar regarding to demographic characteristics. All operations were completed laparoscopically with no conversions to open surgery. In 3 cases without renal stones and 15 cases with renal stones, transposition of the ureter due to crossing vessels was performed. The mean stone size was 13±5.24 mm, and the median number of stones was 1 (1-18). The success of laparoscopic pyeloplasty with and without pyelolithotomy was 93.3% and 92.9%, respectively, as confirmed by negative diuretic renogram at postoperative 3rd months. Overall stone-free rate after laparoscopic pyelolithotomy was 93.3%. Mean operative time was 222.6765.71 minutes vs. 219.11±75.63 minutes for the pyeloplasty with concomitant pyelolithotomy vs. pyeloplasty, respectively (p=0.88). Conclusions Laparoscopic pyeloplasty with concomitant pyelolithotomy is a safe and effective intervention with associated good cosmetic results and high stone-free rates without significant increase in operative time or complications.
DOI: 10.6084/m9.figshare.10296164
title: Interrelation Among Morphology, Mechanical Properties and Oxidation Behavior of NbxAlyNz Thin Films

description: NbxAlyNz thin films were deposited by magnetron sputtering reactive technique with (y/x+y) ratio varying from 0 to 0.4, in order to maintain aluminum atoms inside NbN matrix in solid solution. GAXRD analyses revealed that the crystalline phase obtained for NbxAlyNz thin films was B1-NbN with a lattice constant shrinkage as Al concentration at these coatings was increased. Due to similarity in electro negativity values between Nb and Al, XPS analyses could not verify pronounced changes among as deposited NbxAlyNz coatings. The average hardness values evidenced that solid solution strengthening mechanism did not increase hardness significantly. The oxidation resistance increased with Al content and no oxide phases were registered by GAXRD analyses for coating with more aluminum added. However, SEM images revealed bubbles after oxidation at high temperatures for all samples.
DOI: 10.6084/m9.figshare.10296158
title: IMPROVEMENT OF REACTION TIME AFTER A WORKPLACE PHYSICAL ACTIVITY INTERVENTION

description: ABSTRACT Introduction Work activities have been occupying an increasing amount of time in the daily lives of the population, making individuals less physically active. A job market strategy is to invest in physical exercise programs in the actual workplace to improve the physical and cognitive aspects of these employees. Objective To verify the effects of a workplace physical exercise program on the simple and choice reaction times of public university employees. Methods Twenty-six physically inactive male and female subjects with a mean age of 29.62 ± 6.47 years underwent a program consisting of thirty-six sessions with physical exercises in the workplace, held three times a week over twelve weeks. Simple reaction time (SRT) and choice reaction time (CRT) were assessed before and after the intervention, using the Vienna Test System®, and the results were presented in: I) reaction time, II) movement time; and (III) response time. Descriptive and inferential statistical analyses were conducted using the statistical program SPSS® (version 21.0 for Windows), with a significance level of 5%. Results When observing the SRT and CRT variables before and after the experiment, we noticed an improvement in reaction time, movement time and response time in the experimental group but not in the control group. Conclusion The workplace physical exercise program was able to reduce the SRT and CRT of the experimental group. Level of evidence I; randomized clinical trial.
DOI: 10.6084/m9.figshare.10296161.v1
title: Comparison of the outcomes of laparoscopic pyeloplasty with and without concomitant pyelolithotomy

description: ABSTRACT Objective We aimed to evaluate the results of laparoscopic pyeloplasty with concomitant pyelolithotomy and compare results with a cohort of patients undergoing laparoscopic pyeloplasty without pyelolithotomy. Materials and Methods We retrospectively reviewed records of 43 patients undergoing transperitoneal laparoscopic Anderson-Hynes dismembered pyeloplasty between December 2012 and July 2018 at our department. Eighteen patients (42%) underwent laparoscopic pyeloplasty with concomitant pyelolithotomy. The results of patients with renal stones were compared with 25 matched patients undergoing laparoscopic pyeloplasty without concomitant renal stones. Demographic data, operative and stone parameters were compared between the groups. Results The groups were similar regarding to demographic characteristics. All operations were completed laparoscopically with no conversions to open surgery. In 3 cases without renal stones and 15 cases with renal stones, transposition of the ureter due to crossing vessels was performed. The mean stone size was 13±5.24 mm, and the median number of stones was 1 (1-18). The success of laparoscopic pyeloplasty with and without pyelolithotomy was 93.3% and 92.9%, respectively, as confirmed by negative diuretic renogram at postoperative 3rd months. Overall stone-free rate after laparoscopic pyelolithotomy was 93.3%. Mean operative time was 222.6765.71 minutes vs. 219.11±75.63 minutes for the pyeloplasty with concomitant pyelolithotomy vs. pyeloplasty, respectively (p=0.88). Conclusions Laparoscopic pyeloplasty with concomitant pyelolithotomy is a safe and effective intervention with associated good cosmetic results and high stone-free rates without significant increase in operative time or complications.
DOI: 10.6084/m9.figshare.10296164.v1
title: Interrelation Among Morphology, Mechanical Properties and Oxidation Behavior of NbxAlyNz Thin Films

description: NbxAlyNz thin films were deposited by magnetron sputtering reactive technique with (y/x+y) ratio varying from 0 to 0.4, in order to maintain aluminum atoms inside NbN matrix in solid solution. GAXRD analyses revealed that the crystalline phase obtained for NbxAlyNz thin films was B1-NbN with a lattice constant shrinkage as Al concentration at these coatings was increased. Due to similarity in electro negativity values between Nb and Al, XPS analyses could not verify pronounced changes among as deposited NbxAlyNz coatings. The average hardness values evidenced that solid solution strengthening mechanism did not increase hardness significantly. The oxidation resistance increased with Al content and no oxide phases were registered by GAXRD analyses for coating with more aluminum added. However, SEM images revealed bubbles after oxidation at high temperatures for all samples.
DOI: 10.6084/m9.figshare.10296158.v1
title: IMPROVEMENT OF REACTION TIME AFTER A WORKPLACE PHYSICAL ACTIVITY INTERVENTION

description: ABSTRACT Introduction Work activities have been occupying an increasing amount of time in the daily lives of the population, making individuals less physically active. A job market strategy is to invest in physical exercise programs in the actual workplace to improve the physical and cognitive aspects of these employees. Objective To verify the effects of a workplace physical exercise program on the simple and choice reaction times of public university employees. Methods Twenty-six physically inactive male and female subjects with a mean age of 29.62 ± 6.47 years underwent a program consisting of thirty-six sessions with physical exercises in the workplace, held three times a week over twelve weeks. Simple reaction time (SRT) and choice reaction time (CRT) were assessed before and after the intervention, using the Vienna Test System®, and the results were presented in: I) reaction time, II) movement time; and (III) response time. Descriptive and inferential statistical analyses were conducted using the statistical program SPSS® (version 21.0 for Windows), with a significance level of 5%. Results When observing the SRT and CRT variables before and after the experiment, we noticed an improvement in reaction time, movement time and response time in the experimental group but not in the control group. Conclusion The workplace physical exercise program was able to reduce the SRT and CRT of the experimental group. Level of evidence I; randomized clinical trial.
DOI: 10.6084/m9.figshare.10296137
title: Empowering Adolescent Mothers in the Choice of Contraceptive Methods at the Postpartum Period: Avoiding a Subsequent Pregnancy

description: Abstract Objective Almost 80% of adolescent pregnancies are unplanned, and between 28 and 63% of adolescent mothers had a repeated pregnancy within 18 months. Among girls with repeated pregnancies, two-thirds reported that the pregnancy was unplanned. We aim to assess contraceptive use by adolescent mothers with increasing choice for long-acting reversible contraception (LARC) methods in postpartum consultation after a semistructured group intervention involving adolescent mothers. Methods Retrospective observational study conducted at the Universidade Estadual de Campinas, Campinas, state of São Paulo, Brazil, involving new antenatal and postpartum education groups for adolescents. At postpartum consultations, the adolescents chose their contraceptive. The datawas compared with previous series followed in a period before the implementation of the education group - a historical control group. Results We included 129 adolescent after childbirth from January 1st, 2015 through July 31st, 2017. Out of this total, 63% had ever used contraceptive methods before pregnancy, and the most frequent method was combined oral contraceptives (33%) followed by condoms (21%). At the first postpartum consultation, the most common contraceptive chosen was intrauterine contraception (IUC) (37.2%) and depot-medroxyprogesterone acetate (DMPA) (34.1%).When comparing the rates before and after the education interventions, there was a 3-fold increase in the use of IUCs. Conclusion Antenatal and postpartum education have shown a significant increase in the choice for LARC methods among adolescent mothers, with very high acceptability after a period using the method. The educational groups performed during the antenatal care and beyond the gestational period are easy to be applied worldwide with low dependence on funding.