cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.17632/dnscfxkddd
title: NSP16-deficient SARS-CoV- 2

description: Live attenuated vaccines might elicit mucosal and sterilizing immunity against SARS-CoV-2 that the existing mRNA, adenoviral vector and inactivated vaccines fail to induce. Here, we describe a candidate live attenuated vaccine strain of SARS-CoV-2 in which the NSP16 gene, which encodes 2′-O-methyltransferase, is catalytically disrupted by a point mutation. This virus, designated d16, was severely attenuated in hamsters and transgenic mice, causing only asymptomatic and nonpathogenic infection. A single dose of d16 administered intranasally resulted in sterilizing immunity in both the upper and lower respiratory tracts of hamsters, thus preventing viral spread in a contact-based transmission model. It also robustly stimulated humoral and cell-mediated immune responses, thus conferring full protection against lethal challenge with SARS-CoV-2 in a transgenic mouse model. The neutralizing antibodies elicited by d16 effectively cross-reacted with several SARS-CoV-2 variants. Secretory immunoglobulin A was detected in the blood and nasal wash of vaccinated mice. Our work provides proof-of-principle evidence for harnessing NSP16-deficient SARS- CoV-2 for the development of live attenuated vaccines and paves the way for further preclinical studies of d16 as a prototypic vaccine strain, to which new features might be introduced to improve safety, transmissibility, immunogenicity and efficacy.
DOI: 10.17632/hzptwk77r6
title: LINF_040017250

description: hypothetical protein; Leishmania infantum
DOI: 10.17632/2b2p75vbn7
title: Data used in paper

description: The file includes all the basic data used in our paper, such as, NdFeB trade data, GDP per capita growth rate and life expectancy per capita.
DOI: 10.17632/5zkptzhjz6
title: Original data of Pre-treatment of Interferon-α stimulates DHX58 to prevent hepatic ferroptosis version3

description: Original data of Pre-treatment of Interferon-α stimulates DHX58 to prevent hepatic ferroptosis version3
DOI: 10.17632/95g2kjk6f6
title: LDHU3_10.0190

description: Protein of unknown function - conserved; Leishmania donovani (HU3 strain)
DOI: 10.17632/d9ww5mh46d
title: Amber-free HIV-1 provirus sequences and maps

description: This datasets contain sequences and maps of replication-competent and replication-incompetent amber-free HIV-1 provirus constructs.
DOI: 10.17632/g9cdgwtyrr
title: LINF_360014000

description: Cyclic nucleotide-binding domain-containing protein; Leishmania infantum (strain JPCM5)
DOI: 10.17632/nfmk93cvyh
title: LINF_320044800

description: enolase
Leishmania infantum (strain JPCM5)
DOI: 10.17632/sv38jt4svf
title: Normative Reference norms oh MSTP among school goer

description: Background: The Modified Shuttle Test Paeds (MSTP) offers a practical means of assessing cardiorespiratory fitness in school-age children, addressing the need for a convenient, cost-effective test that can be implemented in pediatric population. MSTP 
Purpose: This study aimed to establish normative reference scores for MSTP in school-going children.
Methods: A sample of 294 participants, accounting for a 10% dropout rate, was recruited. Consent was obtained from school principal and participants were briefed about the procedure. Data on age, height, weight, and heart rate were collected. MSTP involved running 10-meter shuttles to retrieve and deposit pebble bags in trays within a three-minute timeframe. Participants were encouraged to exert maximal effort, with scoring based on the number of bags moved.
Results: In this study, the gender distribution among participants was 51.36% male and 48.64% female. The normative reference value of MSTP was expressed in Geometric mean, mean ±Standard deviation that was 19.14 (19.28 ±3.09).
Conclusion: The normative reference values established in this study of the MSTP provide valuable insights into the cardiorespiratory fitness levels of school-going children. These findings contribute to the field by providing a practical and accessible method for assessing cardiorespiratory fitness in school-going children, thereby supporting efforts to promote health and well-being in this population.
Keywords: Cardiorespiratory Fitness, Cost-Benefit Analysis, Health Promotion, Child, 
Reference Values
DOI: 10.17632/tjmwnb6p3w
title: LDHU3_03.0790

description: Hypothetical protein - conserved; Leishmania donovani (HU3 strain)
DOI: 10.17632/ysst99jj5p
title: Study on the data of Jianpi Yishentongqiao Granules treating allergic rhinitis based on network pharmacology and molecular docking

description: Allergic rhinitis (AR), also known as allergic rhinitis, is an infectious inflammatory reaction involving allergic reactions and inflammatory factors and immune cells in the body, mainly manifested by nasal congestion, runny nose, and itchy nose. AR is the most common allergic disease in the world, and its incidence has been on the rise in recent years. The number of patients worldwide accounts for about 10%-30% of the total population, which seriously affects the work and life of patients.
Jianpi Yishentongqiao Keli(JPYSTQKL) is the chief physician of the tutor Zhang Changxi engaged in clinical medicine for many years, accumulated a lot of experience in the treatment of AR, the Yupingfeng powder, Cangerzi powder, Erxian decoction added and reduced to cut.JPYSTQKL is composed of Aconitum carmichaelii Debeaux (Fuzi, FZ),Leonurus japonicusHoutt.(Chongweizi,CWZ),ministerial herbs Astragalus mongholicus Bunge (Huangqi, HQ), Epimedium sagittatum (Siebold & Zucc.) Maxim. (Yinyanghuo, YYH), Atractylodes macrocephala Koidz.(Baizhu,BZ),Gynochthodes officinalis (F.C.How) Razafim. & B.Bremer(Bajitian,BJT);the adjuvant herbs Saposhnikovia divaricata (Turcz. ex Ledeb.) Schischk.(Fangfeng,FF),Magnolia denudata Desr.(Xinyi,XY),Tabernaemontana divaricata (L.) R.Br. ex Roem. & Schult(Chantui,
CT),Perilla frutescens (L.) Britton(Zisu,ZS)and the messenger herbs Glycyrrhiza glabra L. (Zhigancao, GC), etc.With the use of cold and heat, warm tonifying and qi, so that the lung, spleen and kidney three viscera harmonization, a total of spleen and qi, tonifying kidney and Yang, wind clearing work. We investigated the possible effects of JPYSTQKL on AR through network pharmacology and in vivo experiments. In this paper, 30 key targets of JPYSTQKL, including JUN, IL6, TNF, AKT1, TP53, IL-1β, IL-4, CXCL8, and CCL2, were recorded through the MAPK signaling pathway, IL-17 signaling pathway, and TNF signaling pathway has therapeutic effect on AR rats.
DOI: 10.17632/5632yvtxpg
title: Hew & Lindell Psychologists' Cheek Bias Dataset

description: Hew and Lindell dataset for study examining posing biases in psychologists' professional portraits.
DOI: 10.17632/7rsp4bhnf3
title: Evolution of fracture and creep properties of kerogen with thermal maturity

description: Supplementary Information for "Evolution of fracture and creep properties of kerogen with thermal maturity"
DOI: 10.17632/f63t28m5cb
title: Walther_CellReports_2024_PAPAnalysis

description: Code for PAPA data analysis associated with Walther et al., Cell Reports, 2024 (https://www.cell.com/cell-reports/fulltext/S2211-1247(24)01265-8)

Walther, N., S. Anantakrishnan, T.G.W. Graham, G.M. Dailey, R. Tjian, and X. Darzacq. Automated live-cell single-molecule tracking in enteroid monolayers reveals transcription factor dynamics probing lineage-determining function. 2024. Cell Rep. 43(11): 114914. https://doi.org/10.1016/j.celrep.2024.114914.

Contact: nikewalther.science@gmail.com
DOI: 10.17632/gw8t6m3brj
title: Rucom

description: My research hypothesis is that intangible assets can have a significant impact on market capitalization of the companies. My data contains information about various indicators of the companies in 2016-2021 yy. Data is gathered from financial reports of the companies.
DOI: 10.17632/yvhgrxv2y9
title: REDD+: The Opportunity for Sustainable Management in Zagros Forests 

description: This file contains tables and figures related to REDD+ project research in the Zagros forests of   Iran  that aimed to evaluate the changes of forest cover of Lordegan cities located in Chaharmahal and Bakhtiari province, Iran using forest cover maps produced from Landsat satellites 5, 7 and 8 belonging to 1998, 2008 and 2018. Then, the potential for forest cover transfer to non-forest regions was modeled to identify the regions subject to deforestation using logistic regression model and Markov chain was used to predict changes. In addition, receiver operating characteristics (ROC) were used for validation..
DOI: 10.17632/znjsyz3kzy
title: Unidade Hermenêutica_Diretrizes Nacionais para o Parto Normal [Hermeneutic Unit of the National Guidelines for Normal Childbirth]

description: Repositório público de dados sobre a Unidade Hermenêutica das Diretrizes Nacionais para o Parto Normal [Public data repository on the Hermeneutic Unit of the National Guidelines for Normal Childbirth]
DOI: 10.17632/6w863j7hnf
title: Data SBM Zip

description: There are two files of the dataset about school based management research from 183-2023
DOI: 10.17632/8ncyt7vv68
title: LDHU3_13.0020

description: Hypothetical protein - conserved; Leishmania donovani (HU3 strain)
DOI: 10.17632/jk3rwxv3hh
title: Data for: Artificially high stability of the sodium hydromolybdate ion pair in aqueous solution

description: Raw data for the figure in the manuscript by Pokrovski, Wilke and Kokh to be published in Geochimica et Cosmochimica Acta as "Artificially high stability of the sodium hydromolybdate ion pair in aqueous solution".
DOI: 10.17632/mxw6w7bn8c
title: Immature stages of Aedes albopictus in Yucatan, Mexico

description: The study evaluated the seasonality and bioclimatic conditions necessary for Ae. albopictus' survival in a low-deciduous forest. The majority of the containers that were infested with immature organisms were categorized as large, with a capacity of 10 liters. These containers had organic matter that was classified as low to medium, and the water inside them had a light to semi-dark color. They were placed below the Alvaradoa amorphoides and Bromelia karatas trees. At the same time, the population of Ae. albopictus decreased because predators such as amphibian larvae and Toxorhynchites moctezuma were present in the containers. The results suggest that the Asian mosquito is established in the forest area where the study was carried out. Aedes albopictus is considered a bridge species that can disperse from natural areas to human settlements. Therefore, it is important to target wild populations, which can infest homes.
DOI: 10.17632/n45s2tbjfn
title: The Bioinformatics Landscape in Greek Environmental omics, ELIXIR-GR Pilot Action: Marine.

description: Α nation-wide survey to gather data on the bioinformatics landscape (practices, needs, opinions) relevant to omic research on non-model organisms. 
The final dataset (Anonymised_raw) comprised 102 individual answers to closed-ended, either dichotomous or multiple-response, and open-ended. To further protect their anonymity, we present the answers for questions 4 (strongest area of expertise) and 5 (main research questions) as a separate, randomized dataset (Anonymised_espertised_questions)
DOI: 10.17632/sp28pcmsm4
title: LDHU3_10.1060

description: Hypothetical protein - conserved; Leishmania donovani (HU3 strain)
DOI: 10.17632/trtkc2dbx6
title: LDHU3_19.0370

description: Intraflagellar transport protein 52 | IFT52; Leishmania donovani (HU3 strain)
DOI: 10.17632/342hb7n3c5
title: Estrogen DNA adduct concentrations from South African Population

description: The DNA adduct metabolites include 4-hydroxyestrone(estradiol)-1-N7-guanine, 4-hydroxyestrone(estradiol)-1-N3-adenine and 2-hydroxyestrone(estradiol)-6-N3-adenine. 
The developed method was validated before urine analysis of Black and White South African females. Concentrations calculated are expressed as ng/mg creatinine.
DOI: 10.17632/g6s7kmnk2x
title: LDHU3_16.1760

description: Transport protein particle (TRAPP) component; Leishmania donovani (HU3 strain)
DOI: 10.17632/r7zpf67hwr
title: mitochondrial genomes

description: Total genomic DNA was extracted using the Ezup Column Animal Genomic DNA Extraction Kit (B518251; Sangon Biotech, Shanghai, China) according to its instruction. A second-generation sequencing library was constructed for each sample with a starting DNA material of 300-1000 ng according to Meyer and Kircher and Li et al. Briefly, the DNA samples were sheared to about 250 bp using a Covaris M220 ultrasonicator (Covaris, Inc., MA, USA). The fragmented DNA samples were checked using electrophoresis with a 1.5% agarose gel. The library construction process include end repair, ligation and fillin Meyer and Kircher (2010) and Li et al. (Li et al. 2013). After amplification, the library products of all samples were mixed in equimolar, and DNA fragments larger than 1 kb were removed by gel extration. The recovered samples were sequenced on an Illumina HiSeq platform with 2x150 paired-end configuation at Genewiz (Suzhou, China).
DOI: 10.17632/rtpst7dzsw
title: Supplemental Table 1. Acne Vulgaris Clinical Trials Meeting Inclusion Criteria

description: We searched ClinicalTrials.gov for completed Acne Vulgaris studies with posted results. Studies were eligible if they were completed between January 1, 2000 and July 1, 2024 and had at least one location within the United States.
DOI: 10.17632/xcm34ztnzz
title: QCNN

description: Quaternion Convolutional Neural Network
DOI: 10.17632/6prkd8w9sm
title: LBPMOLL test problems 

description: Linear bilevel problems with multiple objective functions at the lower level: data of test instances.
These instances have 2 objective functions at the lower-level, 5 or 10 upper-level variables, 10 to 50 lower-level variables, 10-50 constraints.
DOI: 10.17632/7ww37njnsj
title: A naturally DNase-free CRISPR-Cas12c enzyme silences gene expression

description: Original imaging data belonging to the manuscript 'A naturally DNase-free CRISPR-Cas12c enzyme silences gene expression' by Huang et al.
DOI: 10.17632/bbbgynbyn3
title: LINF_040005600

description: hypothetical protein - conserved; Leishmania infantum
DOI: 10.17632/jfwv3z4ps8
title: An extended conformation of SARS-CoV-2 main protease reveals novel allosteric targets

description: The coronavirus main protease (Mpro) is required for viral replication, and has enzymatical activity only as a homodimer. In addition, it is highly conserved among the various coronaviruses. Thus, targeting its dimerization is an effective strategy for developing broad-spectrum allosteric inhibitors to suppress mutation escape. In this study, we first obtained the extended conformation of the native monomer of SARS-CoV-2 Mpro by trapping with nanobodies, and found that the catalytic domain and the helix domain dissociate, revealing novel allosteric targets. We also found another state, a compact conformation, similar to the dimeric form. The Mpro is in equilibrium among the monomeric extended conformation as the precursor of all other states, with the compact conformation as the intermediate state and the dimeric conformation as the active state. We designed an innovative NanoBiT-based high-throughput allosteric inhibitor assay based on the rearranged conformation. In addition, we also identified for the first time a set of allosteric inhibitory nanobodies against Mpro, one of which is also a competitive inhibitor for Mpro. Our results provide insight into the maturation of the coronavirus Mpro and a novel way to develop broad-spectrum anti-coronaviral drugs through targeting the maturation process to inhibit the auto-cleavage of the main protease.
DOI: 10.17632/w9pjcfm397
title: LDHU3_18.1680

description: Zinc finger protein; Leishmania donovani (HU3 strain)
DOI: 10.17632/62pzmpk68b
title: Multi-parameter screen optimizes immunoprecipitation

description: Supplementary video for IP-based Interactome Screen Procedure
DOI: 10.17632/7bjpy3m4bp
title: Gross Social Welfare Expenditures 

description: 1984-2021
DOI: 10.17632/9f5k8vkmsy
title: Some consolidated data of forest resources

description: It shows some statistics of forest resources in Hubei Province of China for 2014-2018. These data are mainly used for forest resources accounting.
DOI: 10.17632/hsf9sdd7mc
title: Late Mesozoic stratigraphic framework of the Great Xing’an Range, NE China, and overprinting by the Mongol–Okhotsk and Paleo-Pacific tectonic regimes

description: The analytical results of SIMS zircon U–Pb dating, LA–ICP–MS zircon U–Pb dating, major and trace elements, and Hf isotope for the samples of late Mesozoic volcanic rocks from the Great Xing’an Range. Table S1 to S4
DOI: 10.17632/hv9h7k499b
title: Interview guide to explore considerations for clinical mastitis treatment decisions, views on antimicrobial stewardship and barriers to adoption of milk culturing practices.

description: Interview guide to explore considerations for clinical mastitis treatment decisions, views on antimicrobial stewardship and barriers to adoption of milk culturing practices.
DOI: 10.17632/jm28kgt7tm
title: A Semantic Blocks Model for contextually enhanced human activity prediction 

description: The experimentation code and generated results data for the Semantic Blocks Model research.
DOI: 10.17632/mh6ttt6p66
title: K-12 online education survey CCNU 2020 Spring

description: Survey data from over 118,000 primary and secondary school students in China regarding their perceptions of their online learning experiences of China’s ‘home study initiative’ during the COVID-19 pandemic
DOI: 10.17632/ngsg4wm666
title: Perylene data

description: Data for "Occurrence and origin of perylene in Paleogene sediments from the Tasmanian Gateway, Australia"
DOI: 10.17632/p5b6467hjy
title: LDHU3_18.2040

description: Noc2p family; Leishmania donovani (HU3 strain)
DOI: 10.17632/sptvjxzdc9
title: Estadística sobre Actividades en I+D en el Sector Empresas

description: Medición de los recursos humanos y financieros destinados a actividades en I+D en el sector empresasVariables de estudio: Empresas que realizan I+D, personal empleado en I+D, gastos en I+D por disciplina científica y por rama de actividadLa url de acceso se dirige al menú de la operación desde donde se pueden visualizar como html y descargar las diferentes tablas que componen la publicación. La descarga se puede realizar en formato pc-axis, excel y CSV
DOI: 10.17632/y5222c7cys
title: LDHU3_09.0700

description: Flagellum attachment zone protein 3 | FAZ3
Leishmania donovani (HU3 strain)
DOI: 10.17632/ywvd4rhhvp
title: Сближение уровня экономического развития развитых стран Евросоюза со странами Центральной Восточной Европы: достижения и барьеры

description: Расчеты и данные, использованные в выпускной квалификационной работе.
DOI: 10.17632/3779nzm8tz
title: Data for: Heterogeneous Data Approach on Financial development of Selected African Leading Economies

description: The file contain the raw data as well as the cleaned and processed data used in the analysis
DOI: 10.17632/6732npdk5y
title: HSAP9 and CUL2 in prostate tissue and adenocarcinoma

description: In the present study, we evaluated whether HSPA9 and CUL2 immunoexpression is greater in carcinoma than in non-neoplastic prostate tissue and whether Gleason patterns 3 and 4 increased the risk of Gleason score 6 and 7 (3+4) adenocarcinoma, biochemical persistence (BP), biochemical recurrence (BR), biochemical failure after adjuvant therapy (FB-ADJ), biochemical failure after prostatectomy (FB-PRS), biochemical failure after salvage radiotherapy (FB-RT), biochemical failure after salvage hormone and radiotherapy (FB-HTRT), biochemical failure after salvage therapy (BF-SAL) and systemic disease (SD).
DOI: 10.17632/cpdchpng8b
title: Phylogeny, species delimitation, and biogeographical history of Bredia

description: ### Genomic_dataset.vcf.gz
Description: VCF file of the genomic dataset, generated by mapping whole-genome resequencing data of 158 samples to the reference genome of Bredia hirsuta, further filtered based on hard filtering by GATK and linkage disequilibrium (LD) by Plink.

### Plastome_alignment.fasta 
Description: Alignment of 158 plastomes of Bredia using MAFFT. Only one copy of the inverted repeat (IR) region was used in the final alignment. 

### SCO_CDS_dataset.fasta.tar.xz
Description: FASTA file of coding sequence (CDS) of 1,798 single-copy ortholog (SCO) dataset, generated by using the consensus option to replace corresponding positions of the reference genome with single nucleotide polymorphism (SNP) information of each sample by BCFtools.

### SCO_SNP_dataset.vcf.gz
Description: VCF file of single nucleotide polymorphism (SNP) of 1,798 single-copy ortholog (SCO) dataset, extracted from the genomic SNP dataset without linkage disequilibrium (LD) pruning by BCFtools.
DOI: 10.17632/mvb2scfyh5
title: Montmorillonite and Hectorite - Lauric Acid

description: Lauric Acid adsorbed by montmorillonite and hectorite. Implications on Mars.
DOI: 10.17632/r8gh2phrds
title: LDHU3_16.0140

description: Protein of unknown function - conserved; Leishmania donovani (HU3 strain)
DOI: 10.17632/sdzxx4r58x
title: LINF_260005550

description: zinc finger protein; Leishmania infantum (strain JPCM5)
DOI: 10.17632/3y2hfcj8ss
title: metabolomic analysis in WT and 3miR-OE#3 rice plants.

description: The observed opposite alteration in key genes in the lignin and flavonoid synthesis pathways prompted us to analyze the differences in metabolic products between WT and 3miR-OE plants. To this end, we carried out a non-targeted metabolomic and targeted metabolomic analysis to identify metabolites derived from phenylpropanoid pathways. 
01-04 named as 3miR-OE 41-44 named as miR408-OE N1-N4 named as Nip the CK