cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.3535/dsr-wrt-091
title: Pseudogaudryina atlantica (Bailey, 1851)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/kbp-teh-8qx
title: Archaias angulatus (Fichtel & Moll, 1798)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/93k-9g2-4tv
title: Calcarina mayori Cushman, 1924

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/gwp-pt6-2cn
title: Animalia

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/cmn-2z9-241
title: Mollusca

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/961-7ff-var
title: Animalia

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/th5-dhd-6sh
title: †Liebusella arenosa Hofker, 1983

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/6l3-sce-gtt
title: Animalia

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/p27-d7b-jq7
title: Animalia

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/t0q-cjm-9qz
title: Cylindroclavulina bradyi (Cushman, 1911)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/hab-yxd-vff
title: Lenticulina rotulata (Lamarck, 1804)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/y44-t2m-ky0
title: Duvalia

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/08g-21y-1ym
title: †Inoceramus J. Sowerby, 1814

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/cye-fwv-hrg
title: Hyperammina laevigata Wright, 1891

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/20m-4nn-00a
title: Pseudobelus

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/s4w-669-rq4
title: Olcostephanus

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/s6n-jaw-h18
title: Animalia

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/6az-wzm-7h8
title: Animalia

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/j58-rff-gff
title: Animalia

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/88w-1fs-2tj
title: Animalia

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/fyr-783-es6
title: Dendritina d'Orbigny, 1826

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/1cq-1mg-57e
title: Articularia lineata (Brady, 1884)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/hqv-081-bks
title: Heterostegina depressa d'Orbigny, 1826

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/s2q-h8e-t7h
title: Duvalia

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/xpd-wbf-tvs
title: Cetacea Brisson, 1762

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/8kw-7tp-l7e
title: Animalia

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/zpj-t6p-g3b
title: †Galliaecytheridea postrotunda Oertli, 1957

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/kyl-qd3-ye4
title: Osangularia bengalensis (Schwager, 1866)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/7ql-28p-1e0
title: Lituotuba lituiformis (Brady, 1879)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/b1y-2bv-9l7
title: Bigenerina irregularis Phleger & Parker, 1951

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/vvq-nj1-y70
title: Animalia

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/wc0-f00-vtw
title: Animalia

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/kj7-3n1-v2b
title: Animalia

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/sbr-axz-n5t
title: Lenticulina lowmani (Andersen, 1961)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/wbz-yla-bhn
title: Hibolithes

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/4bj-kpy-fkq
title: Uvigerina d'Orbigny, 1826

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/y03-73b-5zy
title: †Terquemia Tate, 1867

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/djj-z3l-8y9
title: Calcarina spengleri (Gmelin, 1791)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/4f7-89k-1yz
title: Lenticulina gibba (d'Orbigny, 1839)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/fl8-f2v-g0f
title: Quinqueloculina reticulata (d'Orbigny, 1826)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/68c-j34-2f2
title: Teschenites

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/a1v-vk7-ykn
title: Gyroidina altiformis Stewart & Stewart, 1930

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.15468/dl.w8ks3d
title: Occurrence Download

description: A dataset containing 108 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Geometry POLYGON((-0.40076 -8.14214,70.40076 -8.14214,70.40076 20.14214,-0.40076 20.14214,-0.40076 -8.14214))",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 "TaxonKey is Carduus keniensis"
 ]
}

 The dataset includes 108 records from 12 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0017649-250811113504898/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.3535/hby-npa-wep
title: Animalia

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.15468/dl.mbq4n9
title: Occurrence Download

description: A dataset containing 53 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Glaucostegus halavi",
 "Country is Egypt",
 "HasCoordinate is true"
 ]
}

 The dataset includes 53 records from 5 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0017647-250811113504898/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.3535/3qx-fla-nw3
title: Crioceratites

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/6zc-0f2-8qj
title: Marsipella elongata Norman, 1878

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/cg6-lfr-sd8
title: Asterorotalia pulchella (d'Orbigny, 1839)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/yd7-4wd-1mx
title: Trilobatus trilobus (Reuss, 1850)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/18z-cra-3tv
title: Amphistegina d'Orbigny, 1826

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/ze5-2tr-vvq
title: Pseudothurmannia

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/alf-6fy-d11
title: Animalia

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/jvf-549-feg
title: Animalia

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/s4t-p1j-jf2
title: Animalia

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/s6k-v1q-p6f
title: Animalia

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/mx7-21t-4p6
title: Mammalia Linnaeus, 1758

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.15468/dl.se6n89
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Glaucostegus halavi",
 "Country is Tunisia",
 "HasCoordinate is true"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0017648-250811113504898/datasets/export for details.
DOI: 10.3535/89j-kw2-k99
title: Animalia

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/gfa-4cy-sgs
title: Trifarina angulosa (Williamson, 1858)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/4bd-m5e-7t2
title: Animalia

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/99e-j0z-ts7
title: Cervus Linnaeus, 1758

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/9ky-dzr-q0l
title: Animalia

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/2vf-hd5-hsq
title: Pseudothurmannia

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/43z-2pt-q1k
title: Animalia

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/4zc-3t7-af7
title: Pseudobelus

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/cj0-jew-yjl
title: Trilobatus sacculifer (Brady, 1877)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/91y-6cr-2y9
title: Eucytherura (Eucytherura) Müller, 1894

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/svl-cxa-tdb
title: Hibolithes

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/br7-845-9w5
title: Animalia

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/crp-w9e-300
title: Haplocytheridea Stephenson, 1936

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/2a3-wna-qaa
title: Animalia

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/lgp-y0h-dwn
title: Crinoidea Miller, 1821

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/r3q-hjw-0r3
title: Calcarina quoyi d'Orbigny in Fornasini, 1908

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/k4y-bh7-6e8
title: Amphistegina lessonii d'Orbigny in Deshayes, 1830

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/yy6-9rk-zbf
title: Marginulina bacheii Bailey, 1851

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/1yt-tfd-c3n
title: Animalia

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/nds-9cj-yg6
title: Animalia

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/5ah-af0-mq8
title: Hibolithes

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/8zr-s24-xxa
title: Calcarina spengleri (Gmelin, 1791)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/v34-wbr-qbw
title: Amphistegina lobifera Larsen, 1976

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/wzn-4m0-3q5
title: Gen. indet. sp. indet.

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/44r-l20-86b
title: Animalia

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/y2a-smw-g9a
title: Animalia

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/4dk-d9h-5pz
title: Peneroplis planatus (Fichtel & Moll, 1798)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/93d-04n-jja
title: Tritaxilina caperata (Brady, 1881)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/drk-nz2-b7g
title: Teschenites

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/7qf-ptm-54h
title: Mammalia Linnaeus, 1758

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/jv7-p51-kda
title: Animalia

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/j9s-2hw-bdp
title: Lenticulina gibba (d'Orbigny, 1839)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/2m5-287-j95
title: Laticarinina pauperata (Parker & Jones, 1865)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/bxp-e7v-mvc
title: Hoeglundina elegans (d'Orbigny, 1826)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/8b8-35z-1xl
title: Sphaeroidina bulloides d'Orbigny in Deshayes, 1832

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/crn-a4s-301
title: Pararotalia venusta (Brady, 1884)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.15468/dl.n5rhuj
title: Occurrence Download

description: A dataset containing 182 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Meconopsis speciosa"
 ]
}

 The dataset includes 182 records from 22 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0017650-250811113504898/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.3535/cnd-yat-0qj
title: Animalia

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/q6a-694-j9a
title: Siphogenerina columellaris (Brady, 1881)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/12k-4ll-pev
title: Pseudobelus

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/l03-3dx-nyp
title: Animalia

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/m9p-rsr-9es
title: Animalia

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/tbw-3m6-gj2
title: Animalia

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/7rx-3vl-vn5
title: Animalia

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.15468/dl.6rkzkb
title: Occurrence Download

description: A dataset containing 2341 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Pheugopedius eisenmanni (T.A.Parker & O'Neill, 1985))",
 "BasisOfRecord is one of (Specimen, Human Observation, Observation, Machine Observation)",
 "HasCoordinate is true",
 "HasGeospatialIssue is false"
 ]
}

 The dataset includes 2341 records from 10 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0293051-220831081235567/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.tbtzkt
title: Occurrence Download

description: A dataset listing the 751 species recorded in GBIF matching the query:
{
 "DatasetKey" : [
 "is University of California, Davis, Center for Plant Diversity - Lichens"
 ]
}

 The dataset's 751 records were derived from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0288922-220831081235567/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.qxrrnv
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Casuariiformes",
 "HasCoordinate is true",
 "Country is Japan",
 "HasGeospatialIssue is false"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0007953-230224095556074/datasets/export for details.
DOI: 10.15468/dl.9nprc3
title: Occurrence Download

description: A dataset containing 222 species occurrences available in GBIF matching the query:
{
 "and" : [
 "BasisOfRecord is one of (Observation, Machine Observation, Human Observation, Material sample, Material citation, Specimen, Occurrence evidence)",
 "Country is Greece",
 "OccurrenceStatus is Present",
 "TaxonKey is Cinclus cinclus (Linnaeus, 1758)",
 "Year 1990-2022"
 ]
}

 The dataset includes 222 records from 7 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0281081-220831081235567/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.4y3cwa
title: Occurrence Download

description: A dataset containing 23108 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Cantorchilus semibadius (Salvin, 1870))",
 "BasisOfRecord is one of (Specimen, Human Observation, Observation, Machine Observation)",
 "HasCoordinate is true",
 "HasGeospatialIssue is false"
 ]
}

 The dataset includes 23108 records from 12 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0293059-220831081235567/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.a9b374
title: Occurrence Download

description: A dataset containing 249 species occurrences available in GBIF matching the query:
{
 "DatasetKey" : [
 "is Réseau Loup - Lynx ONCFS - Réseau Loup-Lynx : Répartition communale Régulière du Loup en 2014"
 ]
}

 The dataset includes 249 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0003921-230530130749713/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.25san8
title: Occurrence Download

description: A dataset containing 4164 species occurrences available in GBIF matching the query:
{
 "and" : [
 "BasisOfRecord is one of (Observation, Machine Observation, Human Observation, Material sample, Material citation, Specimen, Occurrence evidence)",
 "Country is Greece",
 "OccurrenceStatus is Present",
 "TaxonKey is Ciconia ciconia (Linnaeus, 1758)",
 "Year 1990-2022"
 ]
}

 The dataset includes 4164 records from 7 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0281063-220831081235567/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.t6cp4m
title: Occurrence Download

description: A dataset containing 58749 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Lama glama guanicoe (Müller, 1776))",
 "HasCoordinate is true"
 ]
}

 The dataset includes 58749 records from 27 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0067427-240506114902167/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.5p7qzz
title: Occurrence Download

description: A dataset containing 3864 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Lonicera acuminata Wall.",
 "Year is greater than or equal to 1981",
 "HasCoordinate is true"
 ]
}

 The dataset includes 3864 records from 58 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0293055-220831081235567/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.q5m8k2
title: Occurrence Download

description: A dataset containing 273 species occurrences available in GBIF matching the query:
{
 "and" : [
 "BasisOfRecord is one of (Observation, Machine Observation, Human Observation, Material sample, Material citation, Specimen, Occurrence evidence)",
 "Country is Greece",
 "OccurrenceStatus is Present",
 "TaxonKey is Cygnus cygnus (Linnaeus, 1758)",
 "Year 1990-2022"
 ]
}

 The dataset includes 273 records from 5 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0288947-220831081235567/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.6084/m9.figshare.25984136
title: A patent review of SHP2 allosteric inhibitors (2018-present)

description: SHP2 (Src homology region 2-containing protein tyrosine phosphatase 2) is a target of interest for cancer therapy due to its key role in the regulation of the RAS/MAPK signal transduction pathway downstream of Receptor Tyrosine Kinases (RTKs). Moreover, SHP2 can inhibit T cells via the PD-1/PD-L1 pathway. SHP2 plays a critical role in numerous physiological and pathological cellular processes such as cell proliferation, survival, and migration. This review examines SHP2 allosteric inhibitors reported in patents published in Espacenet and Scifinder databases from 2018 to present. An overview of claimed structures is conducted, focusing attention on structural modifications compared to SHP099, the first described allosteric inhibitor of SHP2. Multiple potent allosteric SHP2 inhibitors have been discovered, disclosed, and tested in a variety of preclinical cancer models with strong evidence of efficacy. Fifteen compounds are currently in clinical development, but none of them have been approved for marketing. Until now, long-term benefit of SHP2 inhibitors as monotherapy agents have not been demonstrated due to acquired mechanisms of resistance and/or lack of efficacy. However, combination therapies with a variety of agents, such as MEK, BRAF, EGFR, RAS-G12C and PDL-1 inhibitors, have high potential and are currently an extensive area of investigation.