DOI: 10.5281/zenodo.14989001
title: : Selective Metabolic Reprogramming in Tumor Cells: A Theoretical Approach to Inhibit Metastasis

description: This research was developed with the aim of contributing to the advancement ofknowledge about metastasis and to the development of innovative therapies that canbenefit humanity.The author expresses the wish that the results of this research be used for the commongood, and not for purposes of commercial exploitation or for the obtaining of patentsthat restrict access to treatments and technologies.The author encourages collaboration and the open sharing of information to acceleratescientific progress and to ensure that discoveries are accessible to all who need them.The author believes that scientific knowledge should be a heritage of humanity and thatthe search for a cure for cancer is a cause that transcends individual or commercialinterests.This work outlines a range of possible research directions and hypothetical explorationsconcerning metastasis. It is intended to stimulate further study and discussion within thescientific community. The contents herein represent potential research possibilities andare not presented as established scientific conclusions

Title: Selective Metabolic Reprogramming in Tumor Cells: A TheoreticalApproach to Inhibit MetastasisKeywords: Tumor Metabolism, Aerobic Glycolysis, Metabolic Inhibitors, Metastasis,Cancer TherapyAbstractThis paper proposes a theoretical strategy to contain metastasis through selectivemetabolic reprogramming of tumor cells. Instead of directly targeting epigeneticmechanisms, this approach suggests using specific inhibitors to block aerobic glycolysis(Warburg effect) and redirect metabolism to pathways that induce apoptosis. Thisstrategy, based on well-known metabolic inhibitors and redirection techniques, presentsa lower risk of toxicity and simplifies clinical application. The proposal aims to serve asa basis for future experimental studies.1. IntroductionThe metabolism of tumor cells significantly differs from normal cells, characterized byan excessive reliance on aerobic glycolysis — a phenomenon known as the Warburgeffect. This metabolic adaptation promotes survival and metastatic dissemination.Selective inhibition of this metabolic pathway, combined with redirection to pathwaysthat promote apoptosis, represents a promising and less complex approach to limitmetastatic progression. 

Este trabalho foi desenvolvido com o objetivo de contribuir para o avanço do conhecimento científico, garantindo que suas descobertas sejam acessíveis para a humanidade, sem exploração comercial indevida.

This research was developed with the aim of contributing to the advancement of knowledge and to the development of innovative therapies that can benefit humanity.



The author expresses the wish that the results of this research be used for the common good, and not for purposes of commercial exploitation or for the obtaining of patents that restrict access to treatments and technologies.

The author encourages collaboration and the open sharing of information to accelerate scientific progress and to ensure that discoveries are accessible to all who need them.

The author believes that scientific knowledge should be a heritage of humanity and that the search for cures and advancements is a cause that transcends individual or commercial interests.




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