cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.8987354.v1
title: Durability of Concrete After Fire Through Accelerated Carbonation Tests

description: Degradation of mechanical properties and durability of reinforced concrete structures occur when they are subjected to fire situations, depending on the characteristics of the material, fire duration and the ways of fire extinguishing. Mechanical properties such as compressive strength, tensile strength and elasticity modulus are some examples of typically altered characteristics in concrete during high temperature exposure. Nevertheless, little is known about the advance of the carbonation front on fire-damaged concrete, which is a characteristic directly related to the durability of the structural system. For this purpose, the carbonation front was evaluated in specimens with characteristic strengths of 20 MPa and 35 MPa, subjected to high temperatures (200 °C, 500 ºC and 700 ºC) and different types of cooling (fast and slow). It was observed that the concrete durability is harmed by exposure to high temperatures and fast cooling. However, advance of the carbonation front was not verified in slow cooling situations.
DOI: 10.6084/m9.figshare.8987339
title: Clinical research challenges in rare genetic diseases in Brazil

description: Abstract Rare diseases are defined as conditions with a prevalence of no more than 6.5 per 10,000 people. Although each rare disease individually affects a small number of people, collectively, the 6,000 to 8,000 rare conditions (80% of them with genetic cause) affect around 8% of the world’s population. Research about the natural history and underlying pathophysiological mechanisms of rare diseases, as well as clinical trials with new drugs, are important and necessary to develop new strategies for the treatment of these conditions. This report describes the experience of a clinical research group working with rare diseases in a reference center for lysosomal diseases in Brazil (Medical Genetics Service, Hospital de Clínicas de Porto Alegre). The activities of this research group enabled its participation in several international multicenter clinical research protocols related to the natural history or therapy development for rare genetic diseases. This participation has allowed the development of personal skills and institutional facilities for clinical research. The clinical research developed in our center has raised the quality of the medical assistance provided to non-clinical research patients in addition to enabling early access to new therapies to many patients with orphan conditions.
DOI: 10.6084/m9.figshare.8987339.v1
title: Clinical research challenges in rare genetic diseases in Brazil

description: Abstract Rare diseases are defined as conditions with a prevalence of no more than 6.5 per 10,000 people. Although each rare disease individually affects a small number of people, collectively, the 6,000 to 8,000 rare conditions (80% of them with genetic cause) affect around 8% of the world’s population. Research about the natural history and underlying pathophysiological mechanisms of rare diseases, as well as clinical trials with new drugs, are important and necessary to develop new strategies for the treatment of these conditions. This report describes the experience of a clinical research group working with rare diseases in a reference center for lysosomal diseases in Brazil (Medical Genetics Service, Hospital de Clínicas de Porto Alegre). The activities of this research group enabled its participation in several international multicenter clinical research protocols related to the natural history or therapy development for rare genetic diseases. This participation has allowed the development of personal skills and institutional facilities for clinical research. The clinical research developed in our center has raised the quality of the medical assistance provided to non-clinical research patients in addition to enabling early access to new therapies to many patients with orphan conditions.
DOI: 10.6084/m9.figshare.8987330
title: Preparation of beta-carotene nanoemulsion and evaluation of stability at a long storage period

description: Abstract Carotenoids have a low solubility in water, and therefore their incorporation in foods is impaired. The nanoemulsions are able to protect these compounds and enhance bioavailability. The objective of this study was to develop nanoemulsions with added beta-carotene, evaluating the influence of process variables and the stability at a long storage period. To assess the effects of these variables a Box-Behnken design was performed. The best condition to form a stable emulsion was 7% (w.w-1) of surfactant and 40 °C. All formulations subjected to a thermal stress test remained stable after the test. The use of a higher concentration of soy lecithin (7%, w.w-1) in the development of emulsions conferred greater stability after a freeze-defrost cycle. Furthermore, with this concentration of surfactant, and using a high-speed homogenizer under conditions of 10,000 rpm, 30 °C, and 20 min of shaking time, it was possible to develop stable nanoemulsion with an average diameter of 429 nm. Moreover, the zeta potential indicated system stability. Thus, it was possible to obtain stable nanoemulsion without the use of subsequent equipment, which makes the process less expensive.
DOI: 10.6084/m9.figshare.8987324
title: STATSSCANDLEPLOT: A NEW WAY OF MONITORING OPERATIONAL PERFORMANCE INDICATORS

description: ABSTRACT Operational KPIs play an extremely important role in the process industry, aiding in decision making. However, they need to be reliably calculated to be representative. The present work presents a schematic methodology for the calculation of these KPIs, including techniques of steady-state detection, denoising, error propagation and sensitivity analysis, presented, as far as it is known, in the form of a new graphical tool proposed by the authors named StatSSCandlePlot. The methodology was applied in a real case study of a gas fired boiler in which the indicator studied was its efficiency evaluated by the Stack Loss Method. From the StatSSCandlePlot it was possible to identify the trends of the indicator, the portion of each window in the steady-state, the values to be considered from the indicator and, in a complementary way, to identify the variable that most influences the variation of the indicator, through the sensitivity analysis.
DOI: 10.6084/m9.figshare.8987321
title: Risk profile for antiangiogenic agent-related osteonecrosis of the jaws

description: ABSTRACT To establish the profile of patients who developed antiangiogenic agent-related osteonecrosis of the jaws, and identify the treatments currently used in dental management. We searched the PubMed®/Medline® and Scopus databases using the words “osteonecrosis AND antiangiogenic therapy”, with the following inclusion criteria: articles published in English, case reports, available online, and for an unlimited period. Of the 209 articles retrieved, 18 were selected, for a total of 19 case reports, since one article included two cases that met the inclusion criteria for this study. Medication-related osteonecrosis of the jaws is characterized by exposure of necrotic bone in the oral cavity that does not heal over a period of 8 weeks in patients with no previous history of radiation therapy. Antiangiogenic drugs are indicated in the treatment of certain tumors, since they stop the formation of new blood vessels, controlling tumor growth and the chance of metastasis. Dental prevention is essential in patients who will be put on antiangiogenic agents, to minimize the risk for osteonecrosis.
DOI: 10.6084/m9.figshare.8987330.v1
title: Preparation of beta-carotene nanoemulsion and evaluation of stability at a long storage period

description: Abstract Carotenoids have a low solubility in water, and therefore their incorporation in foods is impaired. The nanoemulsions are able to protect these compounds and enhance bioavailability. The objective of this study was to develop nanoemulsions with added beta-carotene, evaluating the influence of process variables and the stability at a long storage period. To assess the effects of these variables a Box-Behnken design was performed. The best condition to form a stable emulsion was 7% (w.w-1) of surfactant and 40 °C. All formulations subjected to a thermal stress test remained stable after the test. The use of a higher concentration of soy lecithin (7%, w.w-1) in the development of emulsions conferred greater stability after a freeze-defrost cycle. Furthermore, with this concentration of surfactant, and using a high-speed homogenizer under conditions of 10,000 rpm, 30 °C, and 20 min of shaking time, it was possible to develop stable nanoemulsion with an average diameter of 429 nm. Moreover, the zeta potential indicated system stability. Thus, it was possible to obtain stable nanoemulsion without the use of subsequent equipment, which makes the process less expensive.
DOI: 10.6084/m9.figshare.8987324.v1
title: STATSSCANDLEPLOT: A NEW WAY OF MONITORING OPERATIONAL PERFORMANCE INDICATORS

description: ABSTRACT Operational KPIs play an extremely important role in the process industry, aiding in decision making. However, they need to be reliably calculated to be representative. The present work presents a schematic methodology for the calculation of these KPIs, including techniques of steady-state detection, denoising, error propagation and sensitivity analysis, presented, as far as it is known, in the form of a new graphical tool proposed by the authors named StatSSCandlePlot. The methodology was applied in a real case study of a gas fired boiler in which the indicator studied was its efficiency evaluated by the Stack Loss Method. From the StatSSCandlePlot it was possible to identify the trends of the indicator, the portion of each window in the steady-state, the values to be considered from the indicator and, in a complementary way, to identify the variable that most influences the variation of the indicator, through the sensitivity analysis.
DOI: 10.6084/m9.figshare.8987318
title: Reflective function and identity in adolescents with clinical and nonclinical symptoms

description: Abstract Introduction Reflective function is developed in the context of secure attachment and corresponds to the ability to understand one’s mental states and those of others. Thus, identity develops, which relates to the experience of self as unique, continuous and coherent. Objective To identify reflective function and identity features in adolescents with clinical and nonclinical symptoms of mental health problems. Method Participants were 188 Brazilian high school students aged 14-17 years: 30.3% with clinical symptoms and 69.9% with nonclinical symptoms. Results Adolescents with clinical symptoms showed lower levels of reflective function and greater disintegration of identity. Conclusion Adolescence is a vulnerable time for mental health problems associated with reflective function and identity. Early identification of symptoms is a matter that needs attention to prevent future consequences.
DOI: 10.6084/m9.figshare.8987321.v1
title: Risk profile for antiangiogenic agent-related osteonecrosis of the jaws

description: ABSTRACT To establish the profile of patients who developed antiangiogenic agent-related osteonecrosis of the jaws, and identify the treatments currently used in dental management. We searched the PubMed®/Medline® and Scopus databases using the words “osteonecrosis AND antiangiogenic therapy”, with the following inclusion criteria: articles published in English, case reports, available online, and for an unlimited period. Of the 209 articles retrieved, 18 were selected, for a total of 19 case reports, since one article included two cases that met the inclusion criteria for this study. Medication-related osteonecrosis of the jaws is characterized by exposure of necrotic bone in the oral cavity that does not heal over a period of 8 weeks in patients with no previous history of radiation therapy. Antiangiogenic drugs are indicated in the treatment of certain tumors, since they stop the formation of new blood vessels, controlling tumor growth and the chance of metastasis. Dental prevention is essential in patients who will be put on antiangiogenic agents, to minimize the risk for osteonecrosis.
DOI: 10.6084/m9.figshare.8987312
title: Fascioliasis in buffaloes: A 5-year forecast analysis of the disease based on a 15-year survey in Brazil

description: Abstract In South America, fascioliasis caused by the trematode Fasciola hepatica is an anthropozoonosis disease associated with significant economic losses and poor animal welfare. The objective of this study was to determine the prevalence of F. hepatica in the liver of buffaloes slaughtered from 2003 to 2017 in Brazil, and to perform a forecast analysis of the disease for the next five years using the Autoregressive Integrated Moving Average (ARIMA) model. Data analysis revealed an incidence of 7,187 cases out of 226,561 individuals. The disease presented a considerable interannual variation (p&lt;0.005). Fasciola hepatica was more prevalent in the southern states of Brazil; Paraná, Rio Grande do Sul, and Santa Catarina, presenting 11.9, 7.7, and 3.2% of infected livers, respectively. The high frequency of liver condemnation in Paraná was influenced by weather conditions. The ARIMA models calculated a constant trend of the disease, depicting an average of its future prevalence. The models also described a worse-case and a positive-case scenario, calculating the effects of intervention measurements. In reality, there is an urgent need for regular diagnostic in the animals (fecal and immune diagnose) and in the environment (intermediate host), in order to avoid the high rates of infection.
DOI: 10.6084/m9.figshare.8987315
title: Amblyomma scalpturatum Neumann, 1906 (Acari: Ixodidae): confirmation in Acre State, Brazil, and description of parasitism in a human

description: Abstract Amblyomma scalpturatum is a tick species that is unique to South America. It is commonly associated with the Amazon biome and has been reported in some Brazilian states. This tick species exhibits host specificity: it parasitizes tapirs and suidae. Its role in transmitting pathogens to humans is still unknown. Amblyomma scalpturatum is known to be a human-biting tick; however, there is only one report showing that humans make suitable hosts for this species. The knowledge of tick fauna is lacking in the Acre State. This study collected free-living ticks with the aim of finding new records in Acre State. Collections were carried out in Amazon forest fragments in Rio Branco municipality. An A. scalpturatum specimen was identified and submitted sequencing of the ITS-2 gene. This study presents the first molecular confirmation of A. scalpturatum collected in situ in Acre State, North Region, Brazil. This study also presents the first record of a successfully completed feeding by an A. scalpturatum nymph on a human host in the North region of Brazil. Further investigation is needed to ascertain the complete life cycle of this tick species, its seasonality in the environment, and its relationship to pathogens and competence to transmit them.
DOI: 10.6084/m9.figshare.8987309
title: Optimization and release evaluation for tea polyphenols and chitosan composite films with regulation of glycerol and Tween

description: Abstract In order to optimize the performance of chitosan-tea polyphenols composite films, effects of glycerol and Tween on the antioxidative activities and physical performance of chitosan composite films were evaluated. The results indicated that both flexibility and water vapour permeability of chitosan/tea polyphenols films were improved with the addition of glycerol, meanwhile the solubility and swelling degree decreased. Moreover, the release time of antioxidants from films was delayed with the addition of glycerol. The presence of Tween 20 had no significant effect on the tensile strength of films, but changed the DPPH radical scavenging activity depending on the blend ratio of glycerol and Tween. DSC, FTIR and X-ray analysis showed strong interaction among chitosan, tea polyphenols, glycerol and Tween. The optimum ratio was 0.5% tea polyphenols, 1.2% glycerol and 0.1% Tween. This study provided a reference that an optimized chitosan/tea polyphenols composite film could be obtained by the regulation of glycerol and Tween.
DOI: 10.6084/m9.figshare.8987312.v1
title: Fascioliasis in buffaloes: A 5-year forecast analysis of the disease based on a 15-year survey in Brazil

description: Abstract In South America, fascioliasis caused by the trematode Fasciola hepatica is an anthropozoonosis disease associated with significant economic losses and poor animal welfare. The objective of this study was to determine the prevalence of F. hepatica in the liver of buffaloes slaughtered from 2003 to 2017 in Brazil, and to perform a forecast analysis of the disease for the next five years using the Autoregressive Integrated Moving Average (ARIMA) model. Data analysis revealed an incidence of 7,187 cases out of 226,561 individuals. The disease presented a considerable interannual variation (p&lt;0.005). Fasciola hepatica was more prevalent in the southern states of Brazil; Paraná, Rio Grande do Sul, and Santa Catarina, presenting 11.9, 7.7, and 3.2% of infected livers, respectively. The high frequency of liver condemnation in Paraná was influenced by weather conditions. The ARIMA models calculated a constant trend of the disease, depicting an average of its future prevalence. The models also described a worse-case and a positive-case scenario, calculating the effects of intervention measurements. In reality, there is an urgent need for regular diagnostic in the animals (fecal and immune diagnose) and in the environment (intermediate host), in order to avoid the high rates of infection.
DOI: 10.6084/m9.figshare.8987315.v1
title: Amblyomma scalpturatum Neumann, 1906 (Acari: Ixodidae): confirmation in Acre State, Brazil, and description of parasitism in a human

description: Abstract Amblyomma scalpturatum is a tick species that is unique to South America. It is commonly associated with the Amazon biome and has been reported in some Brazilian states. This tick species exhibits host specificity: it parasitizes tapirs and suidae. Its role in transmitting pathogens to humans is still unknown. Amblyomma scalpturatum is known to be a human-biting tick; however, there is only one report showing that humans make suitable hosts for this species. The knowledge of tick fauna is lacking in the Acre State. This study collected free-living ticks with the aim of finding new records in Acre State. Collections were carried out in Amazon forest fragments in Rio Branco municipality. An A. scalpturatum specimen was identified and submitted sequencing of the ITS-2 gene. This study presents the first molecular confirmation of A. scalpturatum collected in situ in Acre State, North Region, Brazil. This study also presents the first record of a successfully completed feeding by an A. scalpturatum nymph on a human host in the North region of Brazil. Further investigation is needed to ascertain the complete life cycle of this tick species, its seasonality in the environment, and its relationship to pathogens and competence to transmit them.
DOI: 10.6084/m9.figshare.8987318.v1
title: Reflective function and identity in adolescents with clinical and nonclinical symptoms

description: Abstract Introduction Reflective function is developed in the context of secure attachment and corresponds to the ability to understand one’s mental states and those of others. Thus, identity develops, which relates to the experience of self as unique, continuous and coherent. Objective To identify reflective function and identity features in adolescents with clinical and nonclinical symptoms of mental health problems. Method Participants were 188 Brazilian high school students aged 14-17 years: 30.3% with clinical symptoms and 69.9% with nonclinical symptoms. Results Adolescents with clinical symptoms showed lower levels of reflective function and greater disintegration of identity. Conclusion Adolescence is a vulnerable time for mental health problems associated with reflective function and identity. Early identification of symptoms is a matter that needs attention to prevent future consequences.
DOI: 10.6084/m9.figshare.8987306
title: Intraspecific food resource partitioning in Brazilian silverside Atherinella brasiliensis (Atheriniformes: Atherinopsidae) in a tropical estuary, Brazil

description: ABSTRACT We investigated the intraspecific partitioning of food resources of the Brazilian silverside Atherinella brasiliensis in a tropical estuary. A total of 1,099 stomachs were analyzed, and the diet consisted mainly of Gastropoda, Ceratopogonidae larvae, Decapoda larvae, Calanoida, Cyclopoida, Hymenoptera and Brachyura. Ordination of the mean volumetric percentage contribution of preys indicated differences in the dietary compositions between sites and size classes. By SIMPER analysis, we detected high dissimilarity between size classes, suggesting ontogenetic niche shifts: the diet of the early juveniles was based in zooplankton, whereas adults consumed mainly benthic macroinvertebrates. These shifts were related to changes in feeding structures and foraging abilities that show a strong relationship with body size, and showed functional trade-offs in swimming capacity, and feeding strategies used to capture prey. Differences in the diet between size classes and habitat selection by Brazilian silverside are likely strategies to avoid intraspecific competition, clearly related to the abundance and accessibility of resources along the estuarine habitats.
DOI: 10.6084/m9.figshare.8987303
title: PRODUCTION AND CHARACTERIZATION OF PRECIPITATED SILICA FROM PALM OIL MILL FLY ASH USING CO2 IMPREGNATION AND MECHANICAL FRAGMENTATION

description: ABSTRACT In this research, sol-gel precipitation using CO2 impregnation and mechanical fragmentation method was applied to produce precipitated silica from Palm Oil Mill Fly Ash (POMFA). Carbon dioxide (CO2) was used in order to reduce the cost of the process and to enable sodium hydroxide recovery. The precipitation process was done in a stirred temperature-controlled baffled glass precipitator. The response surface method with the central composite design was applied to optimize the stirring speed and the CO2 flow rate. The pH and the temperature of the precipitation process were varied for tailoring the specific surface area of the precipitated silica. The mechanical fragmentation and wet crushing process were applied to control the agglomerate particle size of the precipitated silica obtained. The results show that precipitated silica with a specific surface area in the range of 50 - 140 m2/g can be obtained.
DOI: 10.6084/m9.figshare.8987309.v1
title: Optimization and release evaluation for tea polyphenols and chitosan composite films with regulation of glycerol and Tween

description: Abstract In order to optimize the performance of chitosan-tea polyphenols composite films, effects of glycerol and Tween on the antioxidative activities and physical performance of chitosan composite films were evaluated. The results indicated that both flexibility and water vapour permeability of chitosan/tea polyphenols films were improved with the addition of glycerol, meanwhile the solubility and swelling degree decreased. Moreover, the release time of antioxidants from films was delayed with the addition of glycerol. The presence of Tween 20 had no significant effect on the tensile strength of films, but changed the DPPH radical scavenging activity depending on the blend ratio of glycerol and Tween. DSC, FTIR and X-ray analysis showed strong interaction among chitosan, tea polyphenols, glycerol and Tween. The optimum ratio was 0.5% tea polyphenols, 1.2% glycerol and 0.1% Tween. This study provided a reference that an optimized chitosan/tea polyphenols composite film could be obtained by the regulation of glycerol and Tween.