cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.14326989
title: Interval between the application of metsulfuron-methyl and sowing soybean in different production environments

description: ABSTRACT The persistence of herbicides in the soil is extremely important for controlling weeds during the critical period of weed interference, and for determining which substitute crops might be sown. The aim of this study was to evaluate the effect of metsulfuron-methyl when applied at different times in relation to sowing soybean, seeking to determine a safe interval between its application and sowing the legume under different conditions of soil and climate. Two experiments were conducted, one in the district of Campo Mourão in the state of Paraná (PR) (2014/15 crop) and the other in Curitibanos in the state of Santa Catarina (SC) (2015/16 crop). Both experiments were carried out in a randomised block design with four replications. The treatments were arranged in a 2 x 6 + 1 factorial scheme, where factor A represented two doses of metsulfuron-methyl (1.98 and 3.96 g ha-1), and factor B six different intervals between applying the metsulfuron-methyl and sowing the soybean (0, 15, 30, 45, 60 and 75 days after application - DAA), in addition to a control without the application of herbicide, to serve as a standard for comparison. The following were evaluated: percentage phytotoxicity, plant height, stand, number of pods per plant, 100-grain weight and productivity. A difference was seen in the persistence of metsulfuron-methyl for the experiments in Campo Mourão PR, and Curitibanos SC, and was greater for Campo Mourão. The safe interval between applying the metsulfuron-methyl and sowing the soybean was 17 days for the experiment in Curitibanos and 40 days for Campo Mourão. Precipitation volume, pH and organic matter are the main factors to possibly have influenced this interval.
DOI: 10.6084/m9.figshare.14326987.v1
title: Antimicrobial activity of microcapsules with aqueous extract of chambá (Justicia pectoralis Jacq)

description: ABSTRACT To ensure the antimicrobial activity of the aqueous extract of chambá, it is essential to protect its bioactive compounds. The objective was to preserve its characteristics, aiming to provide the food industry with a natural antimicrobial. Three microcapsule formulations made with maltodextrin and cyclodextrin were developed, both including the aqueous extract of chambá leaves dried through lyophilization. The aqueous extract was initially submitted to in vivo toxicity analysis using zebrafish and the microcapsules were characterized through studies of morphology, hygroscopicity, water solubility, particle size, zeta potential, color determination, microencapsulation efficiency and antimicrobial activity. The aqueous extract of chambá was not considered to be toxic. The microcapsules had irregular shapes, with sizes varying from 0.58 to 1.15 µm. Solubility values ranged from 74.69 to 76.8% and hygroscopicity varied from 2.07 to 4.34%. Additionally, it obtained efficient encapsulation of the phenolic compounds, showing antimicrobial activity against Staphylococcus aureus, Listeria monocytogenes, Salmonella Enteritidis and Escherichia coli, with its use being an alternative as a natural antimicrobial agent.
DOI: 10.6084/m9.figshare.14326989.v1
title: Interval between the application of metsulfuron-methyl and sowing soybean in different production environments

description: ABSTRACT The persistence of herbicides in the soil is extremely important for controlling weeds during the critical period of weed interference, and for determining which substitute crops might be sown. The aim of this study was to evaluate the effect of metsulfuron-methyl when applied at different times in relation to sowing soybean, seeking to determine a safe interval between its application and sowing the legume under different conditions of soil and climate. Two experiments were conducted, one in the district of Campo Mourão in the state of Paraná (PR) (2014/15 crop) and the other in Curitibanos in the state of Santa Catarina (SC) (2015/16 crop). Both experiments were carried out in a randomised block design with four replications. The treatments were arranged in a 2 x 6 + 1 factorial scheme, where factor A represented two doses of metsulfuron-methyl (1.98 and 3.96 g ha-1), and factor B six different intervals between applying the metsulfuron-methyl and sowing the soybean (0, 15, 30, 45, 60 and 75 days after application - DAA), in addition to a control without the application of herbicide, to serve as a standard for comparison. The following were evaluated: percentage phytotoxicity, plant height, stand, number of pods per plant, 100-grain weight and productivity. A difference was seen in the persistence of metsulfuron-methyl for the experiments in Campo Mourão PR, and Curitibanos SC, and was greater for Campo Mourão. The safe interval between applying the metsulfuron-methyl and sowing the soybean was 17 days for the experiment in Curitibanos and 40 days for Campo Mourão. Precipitation volume, pH and organic matter are the main factors to possibly have influenced this interval.
DOI: 10.6084/m9.figshare.14326993.v1
title: Development, sensory profile and physicochemical properties of jabuticaba nectar with lyophilized jussara pulp

description: ABSTRACT Jabuticaba and jussara are both fruits from the Brazilian Atlantic Forest and endangered plant species due to their unsustainable exploitation. In order to protect these plants, it is important to develop products made with these fruits. We have developed a ready-to-drink jabuticaba nectar with the addition of lyophilized jussara pulp (LJP) applying sensory tests, such as acceptance test and Check-All-That-Apply (CATA). Optimal sensory conditions ranged between 150 g L-1 and 200 g L-1 for sucrose concentration and between 450 mL L-1 and 550 mL L-1 for jabuticaba pulp concentration. Just-about-right scale showed that the ideal concentration of LJP used as a natural color additive was 7.2 g L-1 (R2=0.99902). Affective test showed that nectars added with LJP had higher acceptance means than samples without the colorant (P&lt;0.05). LJP addition led to 5.0-fold increase in total phenolic contents. Samples colored with LJP had similar sensory descriptive profiles, as well as nectars without jussara colorant, according to CATA results (P&gt;0.05). Jabuticaba nectar added with LJP presented high acceptance among consumers (P&lt;0.05), indicating commercial potential for this product.
DOI: 10.6084/m9.figshare.14326992
title: Nutrient metabolism and ingestive behavior of goats fed diets containing palm tree fruit

description: ABSTRACT The objective was to evaluate the nutrient metabolism and ingestive behavior of goats fed diets containing fruits of Carnauba and Tucum palm trees, abundant in the Northeast region with fruiting in the dry season and use as alternative food for ruminants. For this end, 21 goats fed three diets, one control and two with carnauba or tucum fruits, in a completely randomized design. We determined nutrient intake through total collection of leftovers, faces and urine, as well as energy and nitrogen balance. Ingestive behavior was assessed by visual observations every 5 min for 24 h. There was a reduction in dry matter intake of 0.183 and 0.223 kg/day for diets containing tucum and carnauba fruits, respectively. The intake of digestible protein (78.04 gDP/day) and metabolizable energy (2.51 McalME/day) of the diet containing tucum fruits met the nutritional requirements of the animals, besides resulting in nitrogen balance above 60% and increase of 0.57 Mcal/kgDM of digestible energy of the diets. Diets containing fruits of carnauba required a longer rumination (453.65 min/day), associated with the higher fiber content in their composition. The inclusion of carnauba and tucum fruits in diets composed of corn, soybean and Tifton 85 hay for growing goats promotes a reduction in dry matter intake due to the low quality of the fiber of these fruits. However, the diets containing tucum fruits met the nutritional requirements of goats regarding digestible protein and metabolizable energy, suggesting the use of this alternative food for this category.
DOI: 10.6084/m9.figshare.14326992.v1
title: Nutrient metabolism and ingestive behavior of goats fed diets containing palm tree fruit

description: ABSTRACT The objective was to evaluate the nutrient metabolism and ingestive behavior of goats fed diets containing fruits of Carnauba and Tucum palm trees, abundant in the Northeast region with fruiting in the dry season and use as alternative food for ruminants. For this end, 21 goats fed three diets, one control and two with carnauba or tucum fruits, in a completely randomized design. We determined nutrient intake through total collection of leftovers, faces and urine, as well as energy and nitrogen balance. Ingestive behavior was assessed by visual observations every 5 min for 24 h. There was a reduction in dry matter intake of 0.183 and 0.223 kg/day for diets containing tucum and carnauba fruits, respectively. The intake of digestible protein (78.04 gDP/day) and metabolizable energy (2.51 McalME/day) of the diet containing tucum fruits met the nutritional requirements of the animals, besides resulting in nitrogen balance above 60% and increase of 0.57 Mcal/kgDM of digestible energy of the diets. Diets containing fruits of carnauba required a longer rumination (453.65 min/day), associated with the higher fiber content in their composition. The inclusion of carnauba and tucum fruits in diets composed of corn, soybean and Tifton 85 hay for growing goats promotes a reduction in dry matter intake due to the low quality of the fiber of these fruits. However, the diets containing tucum fruits met the nutritional requirements of goats regarding digestible protein and metabolizable energy, suggesting the use of this alternative food for this category.
DOI: 10.6084/m9.figshare.14326993
title: Development, sensory profile and physicochemical properties of jabuticaba nectar with lyophilized jussara pulp

description: ABSTRACT Jabuticaba and jussara are both fruits from the Brazilian Atlantic Forest and endangered plant species due to their unsustainable exploitation. In order to protect these plants, it is important to develop products made with these fruits. We have developed a ready-to-drink jabuticaba nectar with the addition of lyophilized jussara pulp (LJP) applying sensory tests, such as acceptance test and Check-All-That-Apply (CATA). Optimal sensory conditions ranged between 150 g L-1 and 200 g L-1 for sucrose concentration and between 450 mL L-1 and 550 mL L-1 for jabuticaba pulp concentration. Just-about-right scale showed that the ideal concentration of LJP used as a natural color additive was 7.2 g L-1 (R2=0.99902). Affective test showed that nectars added with LJP had higher acceptance means than samples without the colorant (P&lt;0.05). LJP addition led to 5.0-fold increase in total phenolic contents. Samples colored with LJP had similar sensory descriptive profiles, as well as nectars without jussara colorant, according to CATA results (P&gt;0.05). Jabuticaba nectar added with LJP presented high acceptance among consumers (P&lt;0.05), indicating commercial potential for this product.
DOI: 10.6084/m9.figshare.14326995
title: Physical-chemical properties of meat from confined lambs with different levels of cottonseed in the diet

description: ABSTRACT The aim of this study was to evaluate the effect of different levels of cottonseed (0, 100, 200, 300 and 400 g Kg-1) on the physical and chemical parameters of the meat of finishing lambs. Forty-five uncastrated male lambs were distributed in a completely randomised design with five treatments of nine replications. The pH values were not influenced by the levels of cottonseed. The lipid and ash content showed significant differences, but were not adjusted by the linear or quadratic equations. Losses during thawing increased, as did cohesiveness, and water activity and water retention capacity decreased as the levels of cottonseed in the diet rose. Tocopherols, cooking loss, toughness and chewiness were adjusted using quadratic equations. In the instrumental colour evaluation, L*, b* and h° showed increasing linear behaviour. The inclusion of up to 400 g of cottonseed in the diet affects the physical-chemical composition and the colour of the produced meat.
DOI: 10.6084/m9.figshare.14326995.v1
title: Physical-chemical properties of meat from confined lambs with different levels of cottonseed in the diet

description: ABSTRACT The aim of this study was to evaluate the effect of different levels of cottonseed (0, 100, 200, 300 and 400 g Kg-1) on the physical and chemical parameters of the meat of finishing lambs. Forty-five uncastrated male lambs were distributed in a completely randomised design with five treatments of nine replications. The pH values were not influenced by the levels of cottonseed. The lipid and ash content showed significant differences, but were not adjusted by the linear or quadratic equations. Losses during thawing increased, as did cohesiveness, and water activity and water retention capacity decreased as the levels of cottonseed in the diet rose. Tocopherols, cooking loss, toughness and chewiness were adjusted using quadratic equations. In the instrumental colour evaluation, L*, b* and h° showed increasing linear behaviour. The inclusion of up to 400 g of cottonseed in the diet affects the physical-chemical composition and the colour of the produced meat.
DOI: 10.6084/m9.figshare.14326796.v1
title: Supplementary Fig 2 source data.xlsxCritical roles for the LINC01119-SOCS5 axis as a novel theranostic in triple-negative breast cancersThe LINC01119-SOCS5 axis as a critical theranostic in triple-negative breast cancer

description: The development of triple-negative breast cancer (TNBC) is critically regulated by certain tumor-microenvironment-associated cells called mesenchymal stem/stromal cells (MSCs), which we and others have shown promoted TNBC progression by activating pro-malignant signaling in neighboring cancer cells. Characterization of these cascades will better our understanding of TNBC biology, and stands to bring about therapeutics that can eliminate the morbidity and mortality associated with advanced disease. Here, we focused on the emerging class of non-coding RNAs called long non-coding RNAs or lncRNAs, and utilized a MSC-supported TNBC progression model to identify specific family members of functional relevance to TNBC pathogenesis. Indeed, although some have been described to play functional roles in TNBC, activities for lncRNAs as mediators of tumor-microenvironment-driven TNBC development remain to be fully explored. We report that MSCs stimulated robust expression of LINC01119 in TNBC cells, which in turn induced suppressor of cytokine signaling 5 (SOCS5), leading to accelerated cancer cell growth and tumorigenesis. We show that LINC01119 and SOCS5 exhibited tight correlation across multiple breast cancer gene sets and that they were highly enriched in TNBC patient cohorts. Importantly, we present evidence that the LINC01119-SOCS5 axis served as a powerful prognostic indicator of adverse outcome in TNBC patients, and we demonstrate that its repression severely impaired cancer cell growth. Altogether, our findings identify LINC01119 as a major driver of TNBC development, and delineate critical non-coding RNA theranostics of potential translational utility in the management of advanced TNBC, a class of tumors in most need of effective and targeted therapy.
DOI: 10.6084/m9.figshare.14326796
title: Supplementary Fig 2 source data.xlsxCritical roles for the LINC01119-SOCS5 axis as a novel theranostic in triple-negative breast cancersThe LINC01119-SOCS5 axis as a critical theranostic in triple-negative breast cancer

description: The development of triple-negative breast cancer (TNBC) is critically regulated by certain tumor-microenvironment-associated cells called mesenchymal stem/stromal cells (MSCs), which we and others have shown promoted TNBC progression by activating pro-malignant signaling in neighboring cancer cells. Characterization of these cascades will better our understanding of TNBC biology, and stands to bring about therapeutics that can eliminate the morbidity and mortality associated with advanced disease. Here, we focused on the emerging class of non-coding RNAs called long non-coding RNAs or lncRNAs, and utilized a MSC-supported TNBC progression model to identify specific family members of functional relevance to TNBC pathogenesis. Indeed, although some have been described to play functional roles in TNBC, activities for lncRNAs as mediators of tumor-microenvironment-driven TNBC development remain to be fully explored. We report that MSCs stimulated robust expression of LINC01119 in TNBC cells, which in turn induced suppressor of cytokine signaling 5 (SOCS5), leading to accelerated cancer cell growth and tumorigenesis. We show that LINC01119 and SOCS5 exhibited tight correlation across multiple breast cancer gene sets and that they were highly enriched in TNBC patient cohorts. Importantly, we present evidence that the LINC01119-SOCS5 axis served as a powerful prognostic indicator of adverse outcome in TNBC patients, and we demonstrate that its repression severely impaired cancer cell growth. Altogether, our findings identify LINC01119 as a major driver of TNBC development, and delineate critical non-coding RNA theranostics of potential translational utility in the management of advanced TNBC, a class of tumors in most need of effective and targeted therapy.
DOI: 10.6084/m9.figshare.14326760.v1
title: Fig 3 source data.xlsxCritical roles for the LINC01119-SOCS5 axis as a novel theranostic in triple-negative breast cancersThe LINC01119-SOCS5 axis as a critical theranostic in triple-negative breast cancer

description: The development of triple-negative breast cancer (TNBC) is critically regulated by certain tumor-microenvironment-associated cells called mesenchymal stem/stromal cells (MSCs), which we and others have shown promoted TNBC progression by activating pro-malignant signaling in neighboring cancer cells. Characterization of these cascades will better our understanding of TNBC biology, and stands to bring about therapeutics that can eliminate the morbidity and mortality associated with advanced disease. Here, we focused on the emerging class of non-coding RNAs called long non-coding RNAs or lncRNAs, and utilized a MSC-supported TNBC progression model to identify specific family members of functional relevance to TNBC pathogenesis. Indeed, although some have been described to play functional roles in TNBC, activities for lncRNAs as mediators of tumor-microenvironment-driven TNBC development remain to be fully explored. We report that MSCs stimulated robust expression of LINC01119 in TNBC cells, which in turn induced suppressor of cytokine signaling 5 (SOCS5), leading to accelerated cancer cell growth and tumorigenesis. We show that LINC01119 and SOCS5 exhibited tight correlation across multiple breast cancer gene sets and that they were highly enriched in TNBC patient cohorts. Importantly, we present evidence that the LINC01119-SOCS5 axis served as a powerful prognostic indicator of adverse outcome in TNBC patients, and we demonstrate that its repression severely impaired cancer cell growth. Altogether, our findings identify LINC01119 as a major driver of TNBC development, and delineate critical non-coding RNA theranostics of potential translational utility in the management of advanced TNBC, a class of tumors in most need of effective and targeted therapy.
DOI: 10.6084/m9.figshare.14326787.v1
title: Supplementary Fig 8 source data.xlsxCritical roles for the LINC01119-SOCS5 axis as a novel theranostic in triple-negative breast cancersThe LINC01119-SOCS5 axis as a critical theranostic in triple-negative breast cancer

description: The development of triple-negative breast cancer (TNBC) is critically regulated by certain tumor-microenvironment-associated cells called mesenchymal stem/stromal cells (MSCs), which we and others have shown promoted TNBC progression by activating pro-malignant signaling in neighboring cancer cells. Characterization of these cascades will better our understanding of TNBC biology, and stands to bring about therapeutics that can eliminate the morbidity and mortality associated with advanced disease. Here, we focused on the emerging class of non-coding RNAs called long non-coding RNAs or lncRNAs, and utilized a MSC-supported TNBC progression model to identify specific family members of functional relevance to TNBC pathogenesis. Indeed, although some have been described to play functional roles in TNBC, activities for lncRNAs as mediators of tumor-microenvironment-driven TNBC development remain to be fully explored. We report that MSCs stimulated robust expression of LINC01119 in TNBC cells, which in turn induced suppressor of cytokine signaling 5 (SOCS5), leading to accelerated cancer cell growth and tumorigenesis. We show that LINC01119 and SOCS5 exhibited tight correlation across multiple breast cancer gene sets and that they were highly enriched in TNBC patient cohorts. Importantly, we present evidence that the LINC01119-SOCS5 axis served as a powerful prognostic indicator of adverse outcome in TNBC patients, and we demonstrate that its repression severely impaired cancer cell growth. Altogether, our findings identify LINC01119 as a major driver of TNBC development, and delineate critical non-coding RNA theranostics of potential translational utility in the management of advanced TNBC, a class of tumors in most need of effective and targeted therapy.
DOI: 10.6084/m9.figshare.14326787
title: Supplementary Fig 8 source data.xlsxCritical roles for the LINC01119-SOCS5 axis as a novel theranostic in triple-negative breast cancersThe LINC01119-SOCS5 axis as a critical theranostic in triple-negative breast cancer

description: The development of triple-negative breast cancer (TNBC) is critically regulated by certain tumor-microenvironment-associated cells called mesenchymal stem/stromal cells (MSCs), which we and others have shown promoted TNBC progression by activating pro-malignant signaling in neighboring cancer cells. Characterization of these cascades will better our understanding of TNBC biology, and stands to bring about therapeutics that can eliminate the morbidity and mortality associated with advanced disease. Here, we focused on the emerging class of non-coding RNAs called long non-coding RNAs or lncRNAs, and utilized a MSC-supported TNBC progression model to identify specific family members of functional relevance to TNBC pathogenesis. Indeed, although some have been described to play functional roles in TNBC, activities for lncRNAs as mediators of tumor-microenvironment-driven TNBC development remain to be fully explored. We report that MSCs stimulated robust expression of LINC01119 in TNBC cells, which in turn induced suppressor of cytokine signaling 5 (SOCS5), leading to accelerated cancer cell growth and tumorigenesis. We show that LINC01119 and SOCS5 exhibited tight correlation across multiple breast cancer gene sets and that they were highly enriched in TNBC patient cohorts. Importantly, we present evidence that the LINC01119-SOCS5 axis served as a powerful prognostic indicator of adverse outcome in TNBC patients, and we demonstrate that its repression severely impaired cancer cell growth. Altogether, our findings identify LINC01119 as a major driver of TNBC development, and delineate critical non-coding RNA theranostics of potential translational utility in the management of advanced TNBC, a class of tumors in most need of effective and targeted therapy.