DOI: 10.5061/dryad.4qrfj6qpv
title: Preanesthetic administration of trazodone does not impact anesthetic recovery scores

description: Trazodone is administered to hospitalized equine patients to aid in
 behavioural management. The effects of trazodone on the recovery period
 have not been previously investigated. This retrospective study sought to
 determine if there was an association between trazodone administration and
 recovery quality, time, need for sedation, or reversal agent
 administration. We hypothesized that there would be no difference in
 recovery scores, recovery time, additional sedation, or reversal agent
 administration between horses that received trazodone preoperatively and
 horses that did not. Records were reviewed to identify horses undergoing
 orthopedic MRI between January 2022 and January 2025. 19 horses of these
 horses were administered trazodone prior to anesthesia. Thirty-eight
 horses that matched the case controls but did not receive trazodone were
 also selected. Signalment, anesthetic drug protocol, duration of
 anesthesia, duration of recovery, recovery scores, recovery complications,
 sedation agents, and reversal agents administered during recovery were
 recorded. Fisher's test, independent t-test, and logistic regression
 were used to investigate differences between groups. Significance level
 was set to 5% (p &lt;0.05).
description: # Preanesthetic administration of trazodone does not impact anesthetic
 recovery scores Dataset DOI:
 [10.5061/dryad.4qrfj6qpv](10.5061/dryad.4qrfj6qpv) ## Description of the
 data and file structure Retrospective data collected from medical records
 of horses anesthetized for orthopedic MRI from 2019 to 2025. Data
 collected included signalment, anesthetic protocols, recovery drugs
 administered, recovery times, and recovery complications. ### Files and
 variables #### File: Trazodone_Recovery_Case_Controls.xlsx
 **Description:** Retrospective data collected from anesthesia records of
 horses undergoing anesthesia for a orthopedic MRI. 19 Horses had received
 trazodone prior to anesthesia. 38 horses were selected as a control group.
 Page 1 details data collected from control horses. Page 2 details data
 collected from trazodone cases. Empty cells represent that there was no
 data to correlate with category (ie. no sedative agent administered, no
 complication experienced) ##### Variables * Medical record number * Visit
 number * Date of anesthesia * Sex (Male/Female/ Male Castrated) * Age
 (Year) * Weight (Kg) * Breed * ASA Status (I-V) * Billed for * Procedure *
 Trazodone administration prior to anesthesia (Yes/No) * Trazodone dose (mg
 and mg/kg) * Trazodone administration frequency  * Premedication
 administered (agent name) * Premedication Dose (mg and mg/kg) and route  *
 Additional premedication agent name * Additional premedication dose (mg,
 mg/kg) and route * Opioid administered (agent name) * Opioid dose (mg and
 mg/kg) and route * Induction agent administered (agent name) * Induction
 agent dose (mg and mg/kg) and route * Co-induction agent administered
 (agent name) * Co-induction agent dose (mg and mg/kg) and route *
 Maintenance agent (agent name) * CRI administration (agent name) * Other
 drugs administered during anesthesia * Recovery sedation administered (Y/N
 and agent name) * Recovery sedation dose (mg and mg/kg) and route *
 Additional recovery sedative administered (Y/N and agent name) *
 Additional recovery sedative dose (mg and mg/kg) and route * Tertiary
 recovery sedation administered (Y/N and agent name) * Tertiary recovery
 sedation dose (mg and mg/kg) and route * Reversal agent administered (Y/N
 and agent name) * Reversal agent dose (mg and mg/kg) * Additional reversal
 agent administered (Y/N and agent name) * Additional reversal agent dose
 (mg, mg/kg) and route * Patient position during position (Left or Right
 lateral recumbency) * Patient position during recovery (Left or Right
 lateral recumbency) * Presence of low SpO2 reading (Yes/No) * Presence of
 Hypoxemia (Yes/No) * Presence of tachycardia (Yes/No) * Presence of
 bradycardia (Yes/No) * Presence of hypotension (Yes/No) * Presence of
 hypertension (Yes/No) * Presence of intra-operative complication (Yes/No)
 * Details of Ax Complication (Description of complication experienced
 during anesthetic period) * Recovery score (1-5) * Recovery complication
 (Yes/No) * Details of recovery complication (Description of complication
 experienced during recovery period) * Anesthesia start time (24 hour clock
 time) * Anesthesia end time (24 hour clock time) * Duration of anesthesia
 (minutes) * Duration of recovery (minutes) * Alive at 24 hours post
 procedure (Yes/No) * Cause of death (Description of cause of death)
 Routes: Intravenous - IV, Intramuscular - IM, Subcutaneous - SQ, Oral - PO
 ## Code/software Excel ## Access information Other publicly accessible
 locations of the data: * None Data was derived from the following sources:
 * None