cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.12624350
title: Supplementary Material for: Direct Comparison of (Anthropometric) Methods for the Assessment of Body Composition

description: <b><i>Objective:</i></b> Several methods for the assessment of body composition exist, yet they yield different results. The present study aimed to assess the extent of these differences on a sample of young, healthy subjects. We hypothesised that differences in body composition results obtained with different methods will vary to the extent that a subject can be misclassified into different nutritional categories. <b><i>Research Methods and Procedures:</i></b> Underwater weighing (UWW), bioelectrical impedance analysis (BIA), anthropometry (ANT), and dual-energy X-ray absorptiometry (DXA) were used to assess body composition. An extensive list of ANT regression equations (or sets of equations) was analysed in terms of accuracy and precision relative to DXA. <b><i>Results:</i></b> When DXA-determined body fat (BF) values were taken as a reference, UWW overestimated BF in both genders. In contrast, BIA (measured with a given bioimpedance analyser) underestimated BF in females, although BIA-determined BF did not differ from DXA in males. A huge difference in BF estimates (8–29% for females and 6–29% for males, for DXA-determined BF of 25.5% and 13.9% for females in males, respectively) was observed across a number of ANT regression equations; yet, ANT proved not to be inferior to DXA, provided that regression equations with the highest combinations of accuracy and precision were chosen. <b><i>Conclusions:</i></b> The study proved grounds for comparison of body composition results of young, healthy subjects, obtained with different methods and across a wide range of ANT regression equations. It also revealed a list of the most appropriate ANT regression equations for the selected sample and reported their accuracy and precision.
DOI: 10.6084/m9.figshare.12624350.v1
title: Supplementary Material for: Direct Comparison of (Anthropometric) Methods for the Assessment of Body Composition

description: <b><i>Objective:</i></b> Several methods for the assessment of body composition exist, yet they yield different results. The present study aimed to assess the extent of these differences on a sample of young, healthy subjects. We hypothesised that differences in body composition results obtained with different methods will vary to the extent that a subject can be misclassified into different nutritional categories. <b><i>Research Methods and Procedures:</i></b> Underwater weighing (UWW), bioelectrical impedance analysis (BIA), anthropometry (ANT), and dual-energy X-ray absorptiometry (DXA) were used to assess body composition. An extensive list of ANT regression equations (or sets of equations) was analysed in terms of accuracy and precision relative to DXA. <b><i>Results:</i></b> When DXA-determined body fat (BF) values were taken as a reference, UWW overestimated BF in both genders. In contrast, BIA (measured with a given bioimpedance analyser) underestimated BF in females, although BIA-determined BF did not differ from DXA in males. A huge difference in BF estimates (8–29% for females and 6–29% for males, for DXA-determined BF of 25.5% and 13.9% for females in males, respectively) was observed across a number of ANT regression equations; yet, ANT proved not to be inferior to DXA, provided that regression equations with the highest combinations of accuracy and precision were chosen. <b><i>Conclusions:</i></b> The study proved grounds for comparison of body composition results of young, healthy subjects, obtained with different methods and across a wide range of ANT regression equations. It also revealed a list of the most appropriate ANT regression equations for the selected sample and reported their accuracy and precision.
DOI: 10.6084/m9.figshare.12624275
title: Reinnervation of Meissner’s corpuscles and Merkel -cells by transplantation of embryonic dorsal root ganglion cells after peripheral nerve section in rats

description: <b>Abstract</b> <b>Objectives:</b><b> </b>Transplantation of embryonic motor neurons has been shown to improve motor neuron survival and reinnervation of neuromuscular junctions in peripheral nerves. However, there have been no reports regarding transplantation of sensory neurons and reinnervation of sensory receptors. Therefore, we hypothesized that transplantation of embryonic sensory neurons may improve sensory neuron in the skin and reinnervate Merkel cells and Meissner’s corpuscles. <b>Materials and Methods: </b>We obtained sensory neurons from dorsal root ganglia of 14-day rat embryos. We generated a rat model of Wallerian -degeneration by performing sciatic nerve transection and waiting for one week after. Six months after cell transplantation, we performed histological and electrophysiological examinations in naïve control, surgical control, and cell transplantation groups. <b>Results: </b>The number of nerve fibers in the papillary dermis and epidermal-dermal interface was significantly greater in the cell transplantation than in the surgical control group. The percent of Merkel cells with nerve terminals, as well as the average number of Meissner corpuscles with nerve terminals, were higher in the cell transplantation than in the surgical control group. Moreover, the amplitude and latency of sensory conduction velocity were evoked in rats of the cell transplantation group. <b>Conclusions: </b>We demonstrated that transplantation of embryonic dorsal root ganglion cells improved sensory nerve fiber number and reinnervation of Merkel cells and Meissner’s corpuscles in peripheral nerves.<br>
DOI: 10.6084/m9.figshare.12624275.v2
title: Reinnervation of Meissner’s corpuscles and Merkel -cells by transplantation of embryonic dorsal root ganglion cells after peripheral nerve section in rats

description: <b>Abstract</b> <b>Objectives:</b><b> </b>Transplantation of embryonic motor neurons has been shown to improve motor neuron survival and reinnervation of neuromuscular junctions in peripheral nerves. However, there have been no reports regarding transplantation of sensory neurons and reinnervation of sensory receptors. Therefore, we hypothesized that transplantation of embryonic sensory neurons may improve sensory neuron in the skin and reinnervate Merkel cells and Meissner’s corpuscles. <b>Materials and Methods: </b>We obtained sensory neurons from dorsal root ganglia of 14-day rat embryos. We generated a rat model of Wallerian -degeneration by performing sciatic nerve transection and waiting for one week after. Six months after cell transplantation, we performed histological and electrophysiological examinations in naïve control, surgical control, and cell transplantation groups. <b>Results: </b>The number of nerve fibers in the papillary dermis and epidermal-dermal interface was significantly greater in the cell transplantation than in the surgical control group. The percent of Merkel cells with nerve terminals, as well as the average number of Meissner corpuscles with nerve terminals, were higher in the cell transplantation than in the surgical control group. Moreover, the amplitude and latency of sensory conduction velocity were evoked in rats of the cell transplantation group. <b>Conclusions: </b>We demonstrated that transplantation of embryonic dorsal root ganglion cells improved sensory nerve fiber number and reinnervation of Merkel cells and Meissner’s corpuscles in peripheral nerves.<br>
DOI: 10.6084/m9.figshare.12624275.v1
title: Reinnervation of Meissner’s corpuscles and Merkel -cells by transplantation of embryonic dorsal root ganglion cells after peripheral nerve section in rats

description: <b>Abstract</b> <b>Objectives:</b><b> </b>Transplantation of embryonic motor neurons has been shown to improve motor neuron survival and reinnervation of neuromuscular junctions in peripheral nerves. However, there have been no reports regarding transplantation of sensory neurons and reinnervation of sensory receptors. Therefore, we hypothesized that transplantation of embryonic sensory neurons may improve sensory neuron in the skin and reinnervate Merkel cells and Meissner’s corpuscles. <b>Materials and Methods: </b>We obtained sensory neurons from dorsal root ganglia of 14-day rat embryos. We generated a rat model of Wallerian -degeneration by performing sciatic nerve transection and waiting for one week after. Six months after cell transplantation, we performed histological and electrophysiological examinations in naïve control, surgical control, and cell transplantation groups. <b>Results: </b>The number of nerve fibers in the papillary dermis and epidermal-dermal interface was significantly greater in the cell transplantation than in the surgical control group. The percent of Merkel cells with nerve terminals, as well as the average number of Meissner corpuscles with nerve terminals, were higher in the cell transplantation than in the surgical control group. Moreover, the amplitude and latency of sensory conduction velocity were evoked in rats of the cell transplantation group. <b>Conclusions: </b>We demonstrated that transplantation of embryonic dorsal root ganglion cells improved sensory nerve fiber number and reinnervation of Merkel cells and Meissner’s corpuscles in peripheral nerves.<br>
DOI: 10.6084/m9.figshare.12624224
title: Supplementary Material for: Multicenter Cohort Study to Assess the Association between Changes on Imaging and Outcome after Regorafenib Treatment (KSCC1603)

description: <b><i>Background:</i></b> Molecular targeted drugs having angiogenesis-inhibiting properties allow the induction of necrosis inside tumors. We retrospectively investigated the relationship between changes on imaging associated with regorafenib (REGO) and treatment outcomes using real-world data. <b><i>Patients and Methods:</i></b> The eligibility criteria included an ECOG PS of 0–1, a starting dose of 120 or 160 mg/day of REGO, and a duration of treatment of at least 35 days. Regarding changes on imaging, cavitation in lung lesions (CLL), morphologic response of liver lesions (MRL), and change of liver metastasis density (CLD) were evaluated. <b><i>Results:</i></b> We finally screened 671 cases, and 226 cases were eligible. In total, 172 and 145 patients had lung and liver metastases, respectively. Among the patients with lung metastasis, CLL was found in 69 patients (40.0%). The median progression-free survival (PFS) of the patients with and those without CLL was 3.2 and 2.4 months, respectively (hazard ratio [HR] = 0.758; 95% confidence interval [CI]: 0.529–1.087), and the median overall survival (OS) of these groups was 10.5 and 8.9 months, respectively (HR = 0.862; 95% CI: 0.579–1.285). MRL and CLD of liver metastasis were analyzed in 145 and 90 patients, respectively. The median OS with and without MRL was 8.9 and 8.2 months, respectively, whereas the median OS with and without CLD was 11.6 and 7.7 months, respectively (HR = 0.523; 95% CI: 0.275–0.992). <b><i>Conclusion:</i></b> CLL may predict PFS but not OS among patients with lung metastasis. CLD was predictive of favorable outcomes for REGO in patients with liver metastasis.
DOI: 10.6084/m9.figshare.12624209
title: Supplementary Material for: Sequence Similarities between Viroids and Human MicroRNAs

description: Viroids are minute unencapsidated non-coding circular RNAs known to be present and to cause diseases only in plants. Infections were associated with the occurrence of specific single-stranded RNAs similar in size to miRNAs and endogenous small interfering RNAs, and viroid pathogenicity is suspected to occur through RNA interference. We looked for sequence similarities between viroids and the seed region of human microRNAs (hsa-miRNAs). Viroid genomes were retrieved from GenBank and mature hsa-mi­RNAs were retrieved from miRBase. Two hundred 300-nucleotide-long sequences were randomly generated as controls. BLAST searches were performed using viroids as queries and hsa-miRNAs as subjects with relaxed parameters, and matches involving hsa-miRNA seed regions were considered. A total of 81,021 matches were found, and 1,501 that showed 100% identity with whole hsa-miRNA seed regions were selected. The most frequent matches involved <i>Chrysanthemum stunt viroid</i> or <i>Hop stunt viroid</i>species with hsa-miR-4286, in 365 and 207 cases, respectively. Three hsa-mi­RNAs (miR-4286, miR-6808-5p, and miR-3622a-3p) were involved in 47% of all matches between viroids and hsa-mi­RNAs. Taken together, these findings warrant further investigation on the potential of viroids and their derived small RNAs to cross kingdoms and interact with nucleic acids in humans.
DOI: 10.6084/m9.figshare.12624209.v1
title: Supplementary Material for: Sequence Similarities between Viroids and Human MicroRNAs

description: Viroids are minute unencapsidated non-coding circular RNAs known to be present and to cause diseases only in plants. Infections were associated with the occurrence of specific single-stranded RNAs similar in size to miRNAs and endogenous small interfering RNAs, and viroid pathogenicity is suspected to occur through RNA interference. We looked for sequence similarities between viroids and the seed region of human microRNAs (hsa-miRNAs). Viroid genomes were retrieved from GenBank and mature hsa-mi­RNAs were retrieved from miRBase. Two hundred 300-nucleotide-long sequences were randomly generated as controls. BLAST searches were performed using viroids as queries and hsa-miRNAs as subjects with relaxed parameters, and matches involving hsa-miRNA seed regions were considered. A total of 81,021 matches were found, and 1,501 that showed 100% identity with whole hsa-miRNA seed regions were selected. The most frequent matches involved <i>Chrysanthemum stunt viroid</i> or <i>Hop stunt viroid</i>species with hsa-miR-4286, in 365 and 207 cases, respectively. Three hsa-mi­RNAs (miR-4286, miR-6808-5p, and miR-3622a-3p) were involved in 47% of all matches between viroids and hsa-mi­RNAs. Taken together, these findings warrant further investigation on the potential of viroids and their derived small RNAs to cross kingdoms and interact with nucleic acids in humans.
DOI: 10.6084/m9.figshare.12624212
title: Fig 5 (panels N, O)

description: GFAP and CLDN4 + areas in C57BL/6 mice stereotactically injected with PBS or VEGFA or Plasmatic proteins. <br>
DOI: 10.6084/m9.figshare.12624212.v1
title: Fig 5 (panels N, O)

description: GFAP and CLDN4 + areas in C57BL/6 mice stereotactically injected with PBS or VEGFA or Plasmatic proteins. <br>
DOI: 10.6084/m9.figshare.12624197
title: Fig 5 (panels I, J)

description: GFAP and CLDN4 + areas in Normal Human Astrocyte cultures treated with PBS, HBMEC conditionned media or plasmatic proteins.<br>
DOI: 10.6084/m9.figshare.12624197.v1
title: Fig 5 (panels I, J)

description: GFAP and CLDN4 + areas in Normal Human Astrocyte cultures treated with PBS, HBMEC conditionned media or plasmatic proteins.<br>
DOI: 10.6084/m9.figshare.12624164
title: Fig 5 (panels A, B, C, D)

description: GFAP, ALDH1L1, VIM, CLDN4 mRNA expression level in Normal human astrocyte cultures treated with PBS, HBMEC conditionned media or Plasmatic proteins.<br>
DOI: 10.6084/m9.figshare.12624164.v1
title: Fig 5 (panels A, B, C, D)

description: GFAP, ALDH1L1, VIM, CLDN4 mRNA expression level in Normal human astrocyte cultures treated with PBS, HBMEC conditionned media or Plasmatic proteins.<br>
DOI: 10.6084/m9.figshare.12624146
title: Reddit graph dataset in sparse matrix format

description: The Reddit graph dataset in sparse matrix (.npz) format. Originally published in Will Hamilton, Zhitao Ying, and Jure Leskovec. Inductive Representation Learning on Large Graphs. NeurIPS 2017.
DOI: 10.6084/m9.figshare.12624125
title: Fig 4 (panel G, H)

description: GFAP/B-ACTIN and CLDN4/B-ACTIN protein expression in enriched neurovascular fractions from Dhh<sup>ECKO</sup> versus Ctrl mice.<br>
DOI: 10.6084/m9.figshare.12624134
title: covariates and bugs code

description: Covariates, POI counts, and code for Bayesian spatio-temporal model
DOI: 10.6084/m9.figshare.12624125.v1
title: Fig 4 (panel G, H)

description: GFAP/B-ACTIN and CLDN4/B-ACTIN protein expression in enriched neurovascular fractions from Dhh<sup>ECKO</sup> versus Ctrl mice.<br>
DOI: 10.6084/m9.figshare.12624134.v1
title: covariates and bugs code

description: Covariates, POI counts, and code for Bayesian spatio-temporal model
DOI: 10.6084/m9.figshare.12624110
title: Fig 4 (panel C)

description: IgG distribution between the lumen, PVS and Parenchyma in Dhh<sup>ECKO</sup> vs Ctrl mice under resting condition.<br>
DOI: 10.6084/m9.figshare.12624149.v1
title: Effects of polarization reversal on the pitch angle scattering of radiation belt electrons and ring current protons by EMIC waves

description: Electromagnetic ion cyclotron (EMIC) waves, a type of natural plasma wave with frequencies below the proton gyro-frequency, play a crucial role in the loss of energetic electrons and protons in the Earth’s magnetosphere. The polarization reversal of EMIC waves at crossover frequencies is a well-known phenomenon that occurs when the waves propagate from an equatorial source region to higher latitudes along a geomagnetic field line. However, the influence of this phenomenon on EMIC wave induced particle diffusion has scarcely been studied. Here we determine the effects of polarization reversal of EMIC waves on computations of bounce-averaged pitch angle diffusion coefficients of radiation belt electrons and ring current protons.
DOI: 10.6084/m9.figshare.12624086
title: Scopus

description: Retrieval of list of citing documents from Scopus using advanced search by REFSRCTITLE ("Hong Kong Law Journal" OR "Hong Kong LJ" OR HKLJ OR "HK Law Journal").
DOI: 10.6084/m9.figshare.12624110.v1
title: Fig 4 (panel C)

description: IgG distribution between the lumen, PVS and Parenchyma in Dhh<sup>ECKO</sup> vs Ctrl mice under resting condition.<br>
DOI: 10.6084/m9.figshare.12624032
title: Fig 3 (panels I, J, K)

description: ICAM1 and GFAP + areas in spinal cord cross sections from Dhh<sup>ECKO</sup> vs Ctrl mice under resting condition. <br>
DOI: 10.6084/m9.figshare.12624035
title: Supplementary Material for: Thyroid Hormones within the Normal Range and Cardiac Function in the General Population: The EPIPorto Study

description: <b><i>Background:</i></b> Hypothyroidism and hyperthyroidism are associated with marked changes in cardiac structure and function. However, the association of thyroid function within the normal range with cardiac structure and function in the general population remains uncertain. <b><i>Methods:</i></b> Eight hundred thirty-five subjects aged ≥45 years from the EPIPorto cohort (evaluation between 2006 and 2008) were cross-sectionally analyzed. We excluded participants with TSH, free T4 (FT4), or free T3 (FT3) outside of the reference range or with self-reported cardiovascular or thyroid disease. Cardiac structure and function were evaluated by echocardiography. We used linear regression models unadjusted and adjusted for sex and age (model 1), and sex, age, BMI, diabetes, hypertension, and smoking (model 2). Nonlinear associations were assessed using restricted cubic splines. <b><i>Results:</i></b> The mean age was 61.5 years (SD 10.5); 61.1% of the patients were women. In the adjusted model 2, heart rate was positively associated with FT3; diastolic blood pressure was positively associated with TSH; LV end-diastolic and end-systolic volumes were inversely associated with TSH, and ejection fraction was nonlinearly associated with FT3, with higher ejection fractions near the limits of the reference range. Left ventricle (LV) posterior wall thickness was nonlinearly associated with FT4 in the adjusted model 1, with a greater thickness near the limits of the reference range. Regarding diastolic function, no significant associations were observed in adjusted models. <b><i>Conclusions:</i></b> Thyroid function within the reference range was associated with heart rate, blood pressure, cardiac structure, and function. Increasing thyroid function (lower TSH, higher FT4, or higher FT3) was associated with a higher heart rate, a lower diastolic blood pressure, and larger LV volumes. LV wall thickness and ejection fraction had a U-shaped association with thyroid hormones.
DOI: 10.6084/m9.figshare.12624149
title: Effects of polarization reversal on the particle pitch angle scattering by EMIC waves

description: Electromagnetic ion cyclotron (EMIC) waves, a type of natural plasma wave with frequencies below the proton gyro-frequency, play a crucial role in the loss of energetic particles in the Earth’s magnetosphere. The polarization reversal of EMIC waves at crossover frequencies is a well-known phenomenon that occurs when the waves propagate from an equatorial source region to higher latitudes along a geomagnetic field line. However, the influence of this phenomenon on EMIC wave induced particle diffusion has scarcely been studied. Here we determine the effects of polarization reversal of EMIC waves on computations of bounce-averaged pitch angle diffusion coefficients of particles.
DOI: 10.6084/m9.figshare.12624032.v1
title: Fig 3 (panels I, J, K)

description: ICAM1 and GFAP + areas in spinal cord cross sections from Dhh<sup>ECKO</sup> vs Ctrl mice under resting condition. <br>
DOI: 10.6084/m9.figshare.12623999
title: Fig 2 (panels H, I, J, K)

description: CDH5/B-ACTIN, ZO1/B-ACTIN, FOXO1/B-ACTIN and p-FOXO1/B-ACTIN protein expression in enriched neurovascular fractions from Dhh<sup>ECKO</sup> vs Ctrl mice under resting condition.<br>
DOI: 10.6084/m9.figshare.12624005
title: Fig 2 (panel L)

description: CLDN5 mRNA expression level in Ctrl and Dhh<sup>ECKO</sup> CNS MECs in culture treated with DMSO or a FOXO1 inhibitor. <br>
DOI: 10.6084/m9.figshare.12624026
title: Fig 3 (panels C, D, E, F)

description: CDH5/IB4, CLDN5/IB4, FGB and ALB + areas in spinal cord cross sections from Dhh<sup>ECKO</sup> vs Ctrl mice.<br>
DOI: 10.6084/m9.figshare.12624026.v1
title: Fig 3 (panels C, D, E, F)

description: CDH5/IB4, CLDN5/IB4, FGB and ALB + areas in spinal cord cross sections from Dhh<sup>ECKO</sup> vs Ctrl mice.<br>
DOI: 10.6084/m9.figshare.12623960
title: Medicago sativa genome and annotation files

description: Cultivated alfalfa "Zhongmu No.1" genome sequence, CDS sequence, protein sequence and gff files.
DOI: 10.6084/m9.figshare.12623999.v1
title: Fig 2 (panels H, I, J, K)

description: CDH5/B-ACTIN, ZO1/B-ACTIN, FOXO1/B-ACTIN and p-FOXO1/B-ACTIN protein expression in enriched neurovascular fractions from Dhh<sup>ECKO</sup> vs Ctrl mice under resting condition.<br>
DOI: 10.6084/m9.figshare.12623936
title: Static data with fundamental geographic information

description: Static data with fundamental geographic information, e.g., the road network structure and the POI distribution
DOI: 10.6084/m9.figshare.12623957
title: Fig 2 (panels A, B, C)

description: Dhh, Cldn5 and Zo1 mRNA expression level in CNS MECs isolated from Dhh<sup>ECKO</sup> vs Ctrl mice under resting condition.<br>
DOI: 10.6084/m9.figshare.12624005.v1
title: Fig 2 (panel L)

description: CLDN5 mRNA expression level in Ctrl and Dhh<sup>ECKO</sup> CNS MECs in culture treated with DMSO or a FOXO1 inhibitor. <br>
DOI: 10.6084/m9.figshare.12623927
title: Raw Plaque-2.0 infection scores of the PCL screen, imaged and analysed at EPFL.

description: Barcode indicates the screening plate sequence number defined by EPFL and Well Position gives the well. Plaque2.0-based infection scores are numberOfNuclei reporting the number of nuclei based on Hoechst stai¬ning, numberOfInfectedNuclei refers to the number of GFP reporter-based number of infected nu¬clei, infectionIndex is the ratio of numberOfInfectedNuclei to numberOfNuclei, the GFP reporter-based number of plaques is given by numberOfPlaques and totalVirusIntensity indicates total GFP reporter signal intensity.