cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.15156/bio/sh1752386.08fu
title: SH1752386.08FU

description: UNITE provides a unified way for delimiting, identifying, communicating, and working with DNA-based Species Hypotheses (SH). All fungal ITS sequences in the international nucleotide sequence databases are clustered to approximately the species level by applying a set of dynamic distance values (<0.5 - 3.0%). All species hypotheses are given a unique, stable name in the form of a DOI, and their taxonomic and ecological annotations are verified through distributed, web-based third-party annotation efforts. SHs are connected to a taxon name and its classification as far as possible (phylum, class, order, etc.) by taking into account identifications for all sequences in the SH. An automatically or manually designated sequence is chosen to represent each such SH. These sequences are released (https://unite.ut.ee/repository.php) for use by the scientific community in, for example, local sequence similarity searches and next-generation sequencing analysis pipelines. The system and the data are updated automatically as the number of public fungal ITS sequences grows.
DOI: 10.15156/bio/sh1752387.08fu
title: SH1752387.08FU

description: UNITE provides a unified way for delimiting, identifying, communicating, and working with DNA-based Species Hypotheses (SH). All fungal ITS sequences in the international nucleotide sequence databases are clustered to approximately the species level by applying a set of dynamic distance values (<0.5 - 3.0%). All species hypotheses are given a unique, stable name in the form of a DOI, and their taxonomic and ecological annotations are verified through distributed, web-based third-party annotation efforts. SHs are connected to a taxon name and its classification as far as possible (phylum, class, order, etc.) by taking into account identifications for all sequences in the SH. An automatically or manually designated sequence is chosen to represent each such SH. These sequences are released (https://unite.ut.ee/repository.php) for use by the scientific community in, for example, local sequence similarity searches and next-generation sequencing analysis pipelines. The system and the data are updated automatically as the number of public fungal ITS sequences grows.
DOI: 10.6084/m9.figshare.14921248
title: Additional file 8 of Integration of metabolomics, genomics, and immune phenotypes reveals the causal roles of metabolites in disease

description: Additional file 8. Table S7
DOI: 10.6084/m9.figshare.22785590
title: Prognostic Significance of Nutrition-Associated Markers in Heart Failure with Preserved Ejection Fraction: A Systematic Review and Meta-Analysis

description: Abstract Background The prognostic significance of nutrition indicators in patients with heart failure with preserved ejection fraction (HFpEF) is unclear. Objectives This systematic review and meta-analysis aimed to assess the prognostic value of serum albumin (SA), the geriatric nutritional risk index (GNRI), and the prognostic nutritional index (PNI) in patients with HFpEF. Methods Databases of PubMed, Embase, The Cochrane Library, and Web of Science were systematically searched for all studies published up to January 2022. The prognostic significance of SA, GNRI, and PNI for HFpEF was explored. Pooled hazard ratio (HR) and 95% confidence interval (CI) were estimated using the STATA 15.0 software. The Quality of Prognosis Studies tool was used to assess the quality of studies. Results Nine studies met the inclusion criteria, and 5603 adults with HFpEF were included in the meta-analysis. The analyses showed that a decreased SA or GNRI was significantly related to high all-cause mortality (HR: 1.98; 95% CI: 1.282–3.057; p = 0.002; and HR: 1.812;95% CI: 1.064–3.086; p = 0.029, respectively). Furthermore, a lower SA indicates a bad composite outcome of all-cause mortality and HF rehospitalization (HR: 1.768; 95% CI: 1.483–2.108; p = 0.000), and a lower GNRI was significantly associated with high cardiovascular mortality (HR: 1.922; 95% CI: 1.504–2.457;p = 0.000). However, a lower PNI did not correlate with all-cause mortality (HR: 1.176; 95% CI: 0.858–1.612, p=0.314). Conclusions Our meta-analysis indicates that SA and GNRI may be useful indicators to predict the prognosis of patients with HFpEF.
DOI: 10.6084/m9.figshare.14921215.v1
title: Additional file 21 of Integration of metabolomics, genomics, and immune phenotypes reveals the causal roles of metabolites in disease

description: Additional file 21. Table S20
DOI: 10.6084/m9.figshare.8105498.v1
title: Additional file 11: of Transcriptome and physiological analyses for revealing genes involved in wheat response to endoplasmic reticulum stress

description: Table S7. GO enrichment of DEGs under group â T vs. Dâ . (XLSX 104 kb)
DOI: 10.6084/m9.figshare.14921212
title: Additional file 20 of Integration of metabolomics, genomics, and immune phenotypes reveals the causal roles of metabolites in disease

description: Additional file 20. Table S19
DOI: 10.6084/m9.figshare.14921215
title: Additional file 21 of Integration of metabolomics, genomics, and immune phenotypes reveals the causal roles of metabolites in disease

description: Additional file 21. Table S20
DOI: 10.6084/m9.figshare.14921245.v1
title: Additional file 7 of Integration of metabolomics, genomics, and immune phenotypes reveals the causal roles of metabolites in disease

description: Additional file 7. Table S6
DOI: 10.6084/m9.figshare.14921221
title: Additional file 23 of Integration of metabolomics, genomics, and immune phenotypes reveals the causal roles of metabolites in disease

description: Additional file 23. Table S22
DOI: 10.6084/m9.figshare.14921221.v1
title: Additional file 23 of Integration of metabolomics, genomics, and immune phenotypes reveals the causal roles of metabolites in disease

description: Additional file 23. Table S22
DOI: 10.6084/m9.figshare.7581290.v1
title: Additional file 13: of Differential co-expression networks of long non-coding RNAs and mRNAs in Cleistogenes songorica under water stress and during recovery

description: Summary of differentially expressed TFs identified in C. songorica water-stressed transcriptome. (XLSX 205â kb)
DOI: 10.6084/m9.figshare.7581296
title: Additional file 14: of Differential co-expression networks of long non-coding RNAs and mRNAs in Cleistogenes songorica under water stress and during recovery

description: List of putative orthologues or rice genes in shoot and root of C. songorica. (XLSX 113â kb)
DOI: 10.6084/m9.figshare.8105579
title: Additional file 7: of Transcriptome and physiological analyses for revealing genes involved in wheat response to endoplasmic reticulum stress

description: Table S4. GO enrichment of DEGs under group â D vs. Câ . (XLSX 1113 kb)
DOI: 10.6084/m9.figshare.8105579.v1
title: Additional file 7: of Transcriptome and physiological analyses for revealing genes involved in wheat response to endoplasmic reticulum stress

description: Table S4. GO enrichment of DEGs under group â D vs. Câ . (XLSX 1113 kb)
DOI: 10.6084/m9.figshare.14921224.v1
title: Additional file 24 of Integration of metabolomics, genomics, and immune phenotypes reveals the causal roles of metabolites in disease

description: Additional file 24. Table S23
DOI: 10.6084/m9.figshare.7581296.v1
title: Additional file 14: of Differential co-expression networks of long non-coding RNAs and mRNAs in Cleistogenes songorica under water stress and during recovery

description: List of putative orthologues or rice genes in shoot and root of C. songorica. (XLSX 113â kb)
DOI: 10.6084/m9.figshare.7581302
title: Additional file 15: of Differential co-expression networks of long non-coding RNAs and mRNAs in Cleistogenes songorica under water stress and during recovery

description: List of common conserved drought responsive genes shared across 4 Poaceae species and their expression pattern in C. songorica. (XLSX 291â kb)
DOI: 10.6084/m9.figshare.7581302.v1
title: Additional file 15: of Differential co-expression networks of long non-coding RNAs and mRNAs in Cleistogenes songorica under water stress and during recovery

description: List of common conserved drought responsive genes shared across 4 Poaceae species and their expression pattern in C. songorica. (XLSX 291â kb)
DOI: 10.6084/m9.figshare.7581308.v1
title: Additional file 17: of Differential co-expression networks of long non-coding RNAs and mRNAs in Cleistogenes songorica under water stress and during recovery

description: Primer list for gene specific primers. (XLSX 11â kb)
DOI: 10.6084/m9.figshare.14921200.v1
title: Additional file 17 of Integration of metabolomics, genomics, and immune phenotypes reveals the causal roles of metabolites in disease

description: Additional file 17. Table S16
DOI: 10.6084/m9.figshare.7581323.v1
title: Additional file 2: of Differential co-expression networks of long non-coding RNAs and mRNAs in Cleistogenes songorica under water stress and during recovery

description: RNA-seq data for eighteen samples. (XLSX 10â kb)
DOI: 10.6084/m9.figshare.14921233
title: Additional file 3 of Integration of metabolomics, genomics, and immune phenotypes reveals the causal roles of metabolites in disease

description: Additional file 3. Table S3
DOI: 10.6084/m9.figshare.14921242
title: Additional file 6 of Integration of metabolomics, genomics, and immune phenotypes reveals the causal roles of metabolites in disease

description: Additional file 6. Table S5
DOI: 10.6084/m9.figshare.7581290
title: Additional file 13: of Differential co-expression networks of long non-coding RNAs and mRNAs in Cleistogenes songorica under water stress and during recovery

description: Summary of differentially expressed TFs identified in C. songorica water-stressed transcriptome. (XLSX 205â kb)
DOI: 10.6084/m9.figshare.7581278
title: Additional file 11: of Differential co-expression networks of long non-coding RNAs and mRNAs in Cleistogenes songorica under water stress and during recovery

description: List of over-represented significantly enriched GO terms in common between different combinations of organ/condition comparisons corresponding to the Venn chart in Fig. 4b, c. (XLSX 29â kb)
DOI: 10.6084/m9.figshare.14921206.v1
title: Additional file 19 of Integration of metabolomics, genomics, and immune phenotypes reveals the causal roles of metabolites in disease

description: Additional file 19. Table S18
DOI: 10.6084/m9.figshare.14921224
title: Additional file 24 of Integration of metabolomics, genomics, and immune phenotypes reveals the causal roles of metabolites in disease

description: Additional file 24. Table S23
DOI: 10.6084/m9.figshare.7581278.v1
title: Additional file 11: of Differential co-expression networks of long non-coding RNAs and mRNAs in Cleistogenes songorica under water stress and during recovery

description: List of over-represented significantly enriched GO terms in common between different combinations of organ/condition comparisons corresponding to the Venn chart in Fig. 4b, c. (XLSX 29â kb)
DOI: 10.6084/m9.figshare.14921245
title: Additional file 7 of Integration of metabolomics, genomics, and immune phenotypes reveals the causal roles of metabolites in disease

description: Additional file 7. Table S6
DOI: 10.6084/m9.figshare.7581305.v1
title: Additional file 16: of Differential co-expression networks of long non-coding RNAs and mRNAs in Cleistogenes songorica under water stress and during recovery

description: Putative targets and target mimics of lncRNAs for miRNA in C. songorica. (XLSX 29â kb)
DOI: 10.6084/m9.figshare.7581320.v1
title: Additional file 2: of Correlate tumor mutation burden with immune signatures in human cancers

description: Table S9. Comparison of the results obtained by using different cutoffs to define the higher-TMB and the lower-TMB tumor samples. (XLSX 21 kb)
DOI: 10.6084/m9.figshare.7581344
title: Additional file 6: of Differential co-expression networks of long non-coding RNAs and mRNAs in Cleistogenes songorica under water stress and during recovery

description: Significantly DEGs (FDR ≤ 0.01) in at least one stress treatment and their regulated in shoot and root. (XLSX 2110 kb)
DOI: 10.6084/m9.figshare.8105633.v1
title: Additional file 5: of Cadmium-induced genome-wide DNA methylation changes in growth and oxidative metabolism in Drosophila melanogaster

description: Table S2. Descriptions of enriched GO terms and KEGG pathways. (XLSX 12 kb)
DOI: 10.6084/m9.figshare.19115673
title: The development of a self-management intervention for stroke survivors – My Life After Stroke (MLAS)

description: Long-term needs of stroke survivors (especially psychosocial needs and stroke prevention) are not adequately addressed. Self-management programmes exist but the optimal content and delivery approach is unclear. We aim to describe the process undertook to develop a structured self-management programme to address these unmet needs. Based on the Medical Research Council framework for complex interventions, the development involved three phases: “Exploring the idea”: Evidence synthesis and patient and public involvement (PPI) with stroke survivors, carers and healthcare professionals. “The iterative phase”: Development and iterative refinement of the format, content, underpinning theories and philosophy of the self-management programme My Life After Stroke (MLAS), with PPI. MLAS consists of two individual appointments and four group sessions over nine weeks, delivered interactively by two trained facilitators. It aims to build independence, confidence and hope and focusses on stroke prevention, maximising physical potential, social support and managing emotional responses. MLAS is grounded in the narrative approach and social learning theory. “Ready for research”: The refinement of a facilitator curriculum and participant resources to support programme delivery. Through a systematic process, we developed an evidence- and theory-based self-management programme for stroke survivors MLAS warrants evaluation in a feasibility study.Implications for rehabilitationMy Life After Stroke(MLAS) has been developed using a systematic process, to address the unmet needs of stroke survivors.This systematic process, involved utilising evidence, theories, patient and public involvement, expertise and guidelines from other long-term conditions. This may further help the development of similar self-management programme within the field of stroke.MLAS warrants further evaluation within a feasibility study. My Life After Stroke(MLAS) has been developed using a systematic process, to address the unmet needs of stroke survivors. This systematic process, involved utilising evidence, theories, patient and public involvement, expertise and guidelines from other long-term conditions. This may further help the development of similar self-management programme within the field of stroke. MLAS warrants further evaluation within a feasibility study.
DOI: 10.6084/m9.figshare.8105624
title: Additional file 4: of Cadmium-induced genome-wide DNA methylation changes in growth and oxidative metabolism in Drosophila melanogaster

description: Table S1. Genes associated with identified DMRs and DMGs. (XLSX 12 kb)
DOI: 10.6084/m9.figshare.8105636
title: Additional file 6: of Cadmium-induced genome-wide DNA methylation changes in growth and oxidative metabolism in Drosophila melanogaster

description: Table S3. Gene names and annotations appearing in the lists of DMGs as well as DEGs. (XLSX 15 kb)
DOI: 10.6084/m9.figshare.14921248.v1
title: Additional file 8 of Integration of metabolomics, genomics, and immune phenotypes reveals the causal roles of metabolites in disease

description: Additional file 8. Table S7
DOI: 10.6084/m9.figshare.7974158
title: Diacerein, its beneficial impact on chondrocytes and notable new clinical applications

description: Diacerein (DCN) was obtained by diacetylation of an anthraquinone derivative rhein and was approved by FDA in 2008, in the treatment of osteoarthritis due to its inhibitory effect on proinflammatory cytokines, including IL-6 and IL-1β. It was synthesized in 1980s and marketed as a tablet in some European Union and Asian countries from 1994. Along with its great potential in the treatment of osteoarthritis, its other applications are also being explored day by day, such as in the treatment of psoriasis, epidermolysis bullosa, breast cancer, type 2 diabetes and periodontitis. The main aim of this review is to explore mechanism of action, various applications and side effects associated with DCN. This has been reviewed that apart from the risk of diarrhea on long-term administration of DCN, various clinical studies has also shown its modest benefits in treatment of various pathological conditions. Hence, DCN is emerging as a new and potentially safe derivative with maximum therapeutic efficacies and minimum side effects which can results in improving the living status of patients suffering from various inflammatory diseases.
DOI: 10.6084/m9.figshare.7420142.v1
title: Studies on new substituted pyridazinones: synthesis and biological evaluation

description: We report herein the synthesis and pharmacological evaluation of a new series of 6-aryl-2-(imidazol-1-yl/1,2,4-triazol-1-yl)-2-methyl-4,5-dihydro-(2H)-pyridazin-3-one (3a-j) as potential anticonvulsant and antitubercular agents. The title compounds were prepared by reacting 6-aryl-4,5-dihydro-(2H)-pyridazin-3-one (2a-e) with formaldehyde and secondary cyclic amine imidazole or 1,2,4-triazole as per Mannich reaction. Anticonvulsant activity of pyridazinone derivatives was tested at 50 mg.kg-1 dose level against maximal electroshock (MES), isoniazid (INH, 250 mg.kg-1) and pentylenetetrazole (PTZ at 80 mg.kg-1) induced seizure methods. Phenytoin sodium (25 mg.kg-1) and sodium valproate (100 mg.kg-1) were used as reference drugs for comparison purpose. In-vitro antitubercular activity was tested by Microplate Alamar Blue assay (MABA) method and the results were compared with clinically used antitubercular agents such as INH, Pyrazinamide (PZA) and Streptomycin (STM). None of the screened compounds were found to be neurotoxic at a dose level of 100 mg.kg-1. All the screened compounds (3a-j) significantly reduced the MES, INH and PTZ induced convulsions and thus showed good anticonvulsant activity. The minimum inhibitory concentration (MIC) of the title compounds against M. tuberculosis ranged from 1.6 µg/mL to 6.25 µg/mL in comparison to INH, PZA (3.125 µg/mL) and STM (6.25 µg/mL) which indicated good antitubercular activity.
DOI: 10.6084/m9.figshare.7974980.v1
title: Wound healing activity in rabbits and antimicrobial activity of Hibiscus hirtus ethanolic extract

description: Generally, Plants have immense potential in the wounds management and treatment.In Chinese herbology, Hibiscus plant is a potent herb and have a good medicinal values but not scientifically approached. The present study aims to investigate the wound healing and antimicrobial activity of ethanolic extract of Hibiscus hirtus Linn.(HH). Wound healing activity was carried out by excision, incision and burn wound models. Antimicrobial activity was determined by cup plate method. Healing rate was assessed from the rate of wound contraction, epithelialization rate, tensile strength, hexosamine and hydroxyproline content. From the obtained results, it was indicated that the wound contraction and increased tensile strength of Hibiscus hirtus extract exhibits potent wound healing capacity. Hexosamine and hydroxyproline expression were also correlative with the pattern of healing observed. Histological observation indicates that the wounds treated with Hibiscus hirtus extract and povidone iodine have reduced scar formation and enhances fibroblast proliferation, angiogenesis, keratinization and epithelialization. The Hibiscus hirtus extract has excellent antimicrobial activity against the various organisms. Wound healing activity of our ethanolic extract of Hibiscus hirtus has shown the good effect which has proved by different physical, histological, biochemical parameters. Significant antimicrobial activity shown may be due to major active constituents present in plant.
DOI: 10.6084/m9.figshare.14307123.v1
title: Relationship between photosynthetic pigments and corn production under nitrogen sources

description: ABSTRACT Nitrogen (N) is a dynamic element in the soil, so new nitrogen fertilization alternatives are required as a way of maximizing its efficiency. Besides, vegetation sensors are a way to assess and manage the nutritional demands of plants. This study aimed to evaluate the effect of nitrogen sources on photosynthetic pigments and their correlation with corn grain yield and dry biomass. The experiment was carried out in a randomized block design with nitrogen sources (mineral, organic and biological). Contents of chlorophyll a, b and total, as well as carotenoids, were evaluated. The chlorophyll indices evaluated by both methods were positively correlated with each other and with the grain yield per plant. Nitrogen fertilization 100 % mineral was superior, when compared to the other treatments, with increments of up to 44 %. There was a positive relationship between the methods of determining and estimating the chlorophyll contents. The grain yield per plant showed the highest values when using the 100 % mineral fertilizer source, with increments above 10 %, in relation to the other sources, spending US$ 89.77 on fertilizer and earning over US$ 538.60 on grain yield. There was a positive correlation between the photosynthetic pigments obtained by both methods and grain yield per plant. Both methods are recommended for the evaluation of chlorophyll concentrations.
DOI: 10.6084/m9.figshare.7420142
title: Studies on new substituted pyridazinones: synthesis and biological evaluation

description: We report herein the synthesis and pharmacological evaluation of a new series of 6-aryl-2-(imidazol-1-yl/1,2,4-triazol-1-yl)-2-methyl-4,5-dihydro-(2H)-pyridazin-3-one (3a-j) as potential anticonvulsant and antitubercular agents. The title compounds were prepared by reacting 6-aryl-4,5-dihydro-(2H)-pyridazin-3-one (2a-e) with formaldehyde and secondary cyclic amine imidazole or 1,2,4-triazole as per Mannich reaction. Anticonvulsant activity of pyridazinone derivatives was tested at 50 mg.kg-1 dose level against maximal electroshock (MES), isoniazid (INH, 250 mg.kg-1) and pentylenetetrazole (PTZ at 80 mg.kg-1) induced seizure methods. Phenytoin sodium (25 mg.kg-1) and sodium valproate (100 mg.kg-1) were used as reference drugs for comparison purpose. In-vitro antitubercular activity was tested by Microplate Alamar Blue assay (MABA) method and the results were compared with clinically used antitubercular agents such as INH, Pyrazinamide (PZA) and Streptomycin (STM). None of the screened compounds were found to be neurotoxic at a dose level of 100 mg.kg-1. All the screened compounds (3a-j) significantly reduced the MES, INH and PTZ induced convulsions and thus showed good anticonvulsant activity. The minimum inhibitory concentration (MIC) of the title compounds against M. tuberculosis ranged from 1.6 µg/mL to 6.25 µg/mL in comparison to INH, PZA (3.125 µg/mL) and STM (6.25 µg/mL) which indicated good antitubercular activity.