cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.7591457
title: Thrombomodulin and interleukin 6 as potential biomarkers of endothelial dysfunction and inflammation after renal transplant

description: ABSTRACT Introduction: Endothelial dysfunction may contribute to hypercoagulable and inflammation states presents in renal transplant, chronic kidney disease (CKD) and its causes. These disorders can be evaluated by markers, such as thrombomodulin (TM), von Willebrand factor (vWF) and interleukin 6 (IL-6). Objectives: The aim of this study was to assess TM, vWF and IL-6 in renal transplant recipients (RTR) and associate their plasma levels with primary cause of end-stage renal disease (ESRD) and allograft function. Methods: 160 RTR were grouped according to the primary cause of CKD (G1: glomerulopathy; G2: hypertensive nephrosclerosis; G3: diabetic nephropathy; and G4: other causes/unknown etiology); creatinine plasma levels (C1 &lt; 1.4 and C2 ≥ 1.4 mg/dl); and the estimated glomerular filtration rate (eGFR) (R1&lt; 60 and R2 ≥ 60 ml/min/1.73 m2). TM and vWF were determined by the enzyme-linked immunosorbent assay (ELISA) and IL-6 by flow cytometry. The results were presented as median, minimum and maximum; p-value &lt; 0.05 was considered statistically significant. Results: TM levels were significantly higher in the G1 group compared to the others (G1: 8.38; G2: 5.51; G3: 5.88; G4: 6.33 ng/ml, p &lt; 0.0001), and in the R1 group compared to R2 (R1: 6.65; R2: 6.19 ng/ml, p = 0.02). The concentration of IL-6, measured by the mean fluorescence intensity, was higher in C2 group when compared to C1 (C1: 7.9; C2: 13.35, p = 0.03). There was no difference in vWF levels among groups. TM correlated positively with IL-6 and creatinine, and negatively with eGFR. IL-6 also correlated positively with vWF. Conclusion: TM and IL-6 can be identified as potential markers for evaluating renal graft function. TM was more related to the primary cause of CKD compared to vWF and IL-6.
DOI: 10.6084/m9.figshare.7591463
title: Synthesis of 1,2,3-Triazole Derivatives of 4,4'-Dihydroxybenzophenone and Evaluation of Their Elastase Inhibitory Activity

description: The present investigation describes the synthesis of a series of novel triazole derivatives from 4,4'-dihydroxybenzophenone along with their elastase inhibitory activity. The 1,2,3-triazoles were obtained via the copper(I)-catalyzed azide-alkyne cycloaddition reaction (CuAAC), also known as click reaction, between bis(4-(prop-2-yn-1-yloxy))benzophenone and several benzyl azides. It was found that five derivatives exhibited significant inhibitory effects, presenting half maximal inhibitory concentration (IC50) values in the range of 16.6 to 72.1 µM. The most active compound, namely bis(4-(1-(4-iodobenzyl)-1H-1,2,3-triazol-4-yl)methoxy)benzophenone (IC50 = 16.6 ± 1.9 µM), was found to bind to elastase with the inhibition constant (Ki) of 11.12 µM, thereby illustrating competitive inhibitory behavior. Further, docking investigations provided insights on the possible binding mode of the most active compound with the elastase.
DOI: 10.6084/m9.figshare.7591454
title: Male-Specific Volatiles Released by the Big Avocado Seed Weevil Heilipus lauri Boheman (Coleoptera: Curculionidae)

description: The big avocado seed weevil, Heilipus lauri Boheman (Coleoptera: Curculionidae), is one of the most significant pests of avocado in Colombia and other countries, such as Mexico. The volatile compounds produced by males and females were collected by headspace (HS)-solid phase microextraction (SPME) and dynamic headspace collection (DHS) on a sorbent. Comparative analysis of these volatile compounds was performed using gas chromatography (GC)-flame ionization detector (FID) and GC coupled with mass spectrometry (MS). Four male-specific compounds were identified as grandisol, papayanol, papayanal and grandisal in a ratio of 94.8:3.0:1.8:0.4. Our results may help in integrated pest management by using these semiochemicals for trapping and controlling population of this species.
DOI: 10.6084/m9.figshare.7591457.v1
title: Thrombomodulin and interleukin 6 as potential biomarkers of endothelial dysfunction and inflammation after renal transplant

description: ABSTRACT Introduction: Endothelial dysfunction may contribute to hypercoagulable and inflammation states presents in renal transplant, chronic kidney disease (CKD) and its causes. These disorders can be evaluated by markers, such as thrombomodulin (TM), von Willebrand factor (vWF) and interleukin 6 (IL-6). Objectives: The aim of this study was to assess TM, vWF and IL-6 in renal transplant recipients (RTR) and associate their plasma levels with primary cause of end-stage renal disease (ESRD) and allograft function. Methods: 160 RTR were grouped according to the primary cause of CKD (G1: glomerulopathy; G2: hypertensive nephrosclerosis; G3: diabetic nephropathy; and G4: other causes/unknown etiology); creatinine plasma levels (C1 &lt; 1.4 and C2 ≥ 1.4 mg/dl); and the estimated glomerular filtration rate (eGFR) (R1&lt; 60 and R2 ≥ 60 ml/min/1.73 m2). TM and vWF were determined by the enzyme-linked immunosorbent assay (ELISA) and IL-6 by flow cytometry. The results were presented as median, minimum and maximum; p-value &lt; 0.05 was considered statistically significant. Results: TM levels were significantly higher in the G1 group compared to the others (G1: 8.38; G2: 5.51; G3: 5.88; G4: 6.33 ng/ml, p &lt; 0.0001), and in the R1 group compared to R2 (R1: 6.65; R2: 6.19 ng/ml, p = 0.02). The concentration of IL-6, measured by the mean fluorescence intensity, was higher in C2 group when compared to C1 (C1: 7.9; C2: 13.35, p = 0.03). There was no difference in vWF levels among groups. TM correlated positively with IL-6 and creatinine, and negatively with eGFR. IL-6 also correlated positively with vWF. Conclusion: TM and IL-6 can be identified as potential markers for evaluating renal graft function. TM was more related to the primary cause of CKD compared to vWF and IL-6.
DOI: 10.6084/m9.figshare.7591463.v1
title: Synthesis of 1,2,3-Triazole Derivatives of 4,4'-Dihydroxybenzophenone and Evaluation of Their Elastase Inhibitory Activity

description: The present investigation describes the synthesis of a series of novel triazole derivatives from 4,4'-dihydroxybenzophenone along with their elastase inhibitory activity. The 1,2,3-triazoles were obtained via the copper(I)-catalyzed azide-alkyne cycloaddition reaction (CuAAC), also known as click reaction, between bis(4-(prop-2-yn-1-yloxy))benzophenone and several benzyl azides. It was found that five derivatives exhibited significant inhibitory effects, presenting half maximal inhibitory concentration (IC50) values in the range of 16.6 to 72.1 µM. The most active compound, namely bis(4-(1-(4-iodobenzyl)-1H-1,2,3-triazol-4-yl)methoxy)benzophenone (IC50 = 16.6 ± 1.9 µM), was found to bind to elastase with the inhibition constant (Ki) of 11.12 µM, thereby illustrating competitive inhibitory behavior. Further, docking investigations provided insights on the possible binding mode of the most active compound with the elastase.
DOI: 10.7284/115569
title: GNSS (Global Navigation Satellite System) data collected during research cruise FK140418 using a C&C C-Nav 3050 instrument system onboard the platform RV Falkor

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7591445
title: Influence of Copper and Metallic Alloys on the Oxidation Reaction of Commercial Biodiesel in Mixture with Natural Antioxidant

description: The purpose of this research was to evaluate the influence of metallic alloys and copper in the degradation of biodiesel in mixture with blackberry extract. Biodiesel is formed by unsaturated esters highly susceptible to the oxidation reaction. The initial induction period (IP) of the control sample was 9.53 h and, after 208 days, the IP reduced to 5.74 h. However, with the addition of the antioxidant, the final IP was 6.27 h. The assays involving carbon steel, stainless steel, silver steel and copper showed final IP of 3.78, 4.43, 1.59 and 0.09 h, respectively. This behavior indicates that the reaction was catalyzed in the presence of metal. The addition of the blackberries extract favored the increase of the induction period and the decrease of the reaction rate constant values, aside from the carbon steel that presented a final IP of 1.22 h. The highest rate constant was 7.41 h obtained for biodiesel in contact with copper, as well as the highest IP. The acid number ranged from 0.34 to 0.60 mgKOH g-1. It was possible to observe in the oxidation reactions the presence of the linearity deviation proposed by Arrhenius.
DOI: 10.6084/m9.figshare.7591451
title: Fertigation and growth regulator on coffee seedling production in tubes

description: ABSTRACT The use of quality seedlings is important in establishing a productive coffee crop. However, the most widely used method to produce coffee seedlings is time consuming (6-12 months) and lacks new production technologies. This study aimed to assess the use of fertigation and a growth regulator in the production of coffee seedlings, in order to develop a system faster than the conventional method. For that, Topázio coffee cultivar seeds were pre-germinated and planted in tubes filled with substrate (composted pine bark), in a protected nursery. A randomized block design was used, in a 4 x 2 (fertigation levels x the use or not of growth regulator) factorial scheme, with four replications. Daily fertigation positively influenced all the growth variables evaluated. The foliar spraying of the growth regulator had little effect on seedling growth. When compared to the conventional system described in the literature, the coffee seedling production system described here reduced, by around 60 days, the production time and enables a large-scale production.
DOI: 10.6084/m9.figshare.7591451.v1
title: Fertigation and growth regulator on coffee seedling production in tubes

description: ABSTRACT The use of quality seedlings is important in establishing a productive coffee crop. However, the most widely used method to produce coffee seedlings is time consuming (6-12 months) and lacks new production technologies. This study aimed to assess the use of fertigation and a growth regulator in the production of coffee seedlings, in order to develop a system faster than the conventional method. For that, Topázio coffee cultivar seeds were pre-germinated and planted in tubes filled with substrate (composted pine bark), in a protected nursery. A randomized block design was used, in a 4 x 2 (fertigation levels x the use or not of growth regulator) factorial scheme, with four replications. Daily fertigation positively influenced all the growth variables evaluated. The foliar spraying of the growth regulator had little effect on seedling growth. When compared to the conventional system described in the literature, the coffee seedling production system described here reduced, by around 60 days, the production time and enables a large-scale production.
DOI: 10.6084/m9.figshare.7591454.v1
title: Male-Specific Volatiles Released by the Big Avocado Seed Weevil Heilipus lauri Boheman (Coleoptera: Curculionidae)

description: The big avocado seed weevil, Heilipus lauri Boheman (Coleoptera: Curculionidae), is one of the most significant pests of avocado in Colombia and other countries, such as Mexico. The volatile compounds produced by males and females were collected by headspace (HS)-solid phase microextraction (SPME) and dynamic headspace collection (DHS) on a sorbent. Comparative analysis of these volatile compounds was performed using gas chromatography (GC)-flame ionization detector (FID) and GC coupled with mass spectrometry (MS). Four male-specific compounds were identified as grandisol, papayanol, papayanal and grandisal in a ratio of 94.8:3.0:1.8:0.4. Our results may help in integrated pest management by using these semiochemicals for trapping and controlling population of this species.
DOI: 10.6084/m9.figshare.7591439
title: Investigation of VEGF gene polymorphism rs35569394 in endometriosis

description: ABSTRACT Introduction: Endometriosis is a chronic gynecological condition characterized by the presence of endometrial tissue in locations outside the uterus. Its symptoms include dysmenorrhea, dyspareunia, chronic pelvic pain, infertility, dysuria, and dyschezia. Several studies have related the vascular endothelial growth factor (VEGF) gene polymorphisms as a factor for the development of endometriosis. Objectives: The aim of this study was to compare the frequency of the VEGF gene polymorphism rs35569394 in women with endometriosis and a control group, as well as to investigate the association of this polymorphism with the risk of endometriosis. Methods: This case-control study included 45 endometriosis patients (cases) and 78 controls. The molecular analysis was performed by polymerase chain reaction (PCR). The chi-square test was used to compare the genotype and allele frequencies, and the Hardy-Weinberg equilibrium was also tested using the chi-square test, considering the significance of p &lt; 0.05. Results: The frequency of the II, ID and DD genotype was 24.4% versus 26.9%; 35.6% versus 37.2%; and 40% versus 35.9%, in patients and the control group, respectively. The allele frequencies were I: 0.42 (cases) and 0.45 (control); D: 0.58 (cases) and 0.55 (control). The allele and genotype frequency of VEGF -2549I/D polymorphism was not different between women with endometriosis and the control. Conclusion: In the present study, the frequency of the VEGF gene polymorphism rs35569394 is similar between cases and control. This genetic variant is not associated with endometriosis in the investigated population.
DOI: 10.6084/m9.figshare.7591442
title: Continuous Scanning Technique with Barkhausen Magnetic Noise for Carbon Steel Sheets

description: This work studies the application of a Non-Destructive Inspection Technique (NDIT), based on the Magnetic Barkhausen Noise (MBN), for the detection of non-homogeneous regions in carbon steel plates. It presents the advances in the development of a variant of a new non-destructive magnetic test technique, called Continuous Scanning Magnetic Barkhausen Noise (CSMBN). The non-homogeneous or damaged regions were produced by plastic deformations in rolled and annealed sheets of SAE 1060 and 1070 steels. MBN is generated by abrupt changes in the magnetization of materials when subjected to alteration. The sensitivity of the MBN signals in the detection of plastic deformations was analyzed varying parameters such as excitation magnetic field frequency and the speed of movement of the probe. The behavior of the root mean square of magnetic Barkhausen Noise signal (RMSMBN) parameter was correlated with the position of the nonhomogeneous regions detected in the samples. An evaluation of the technique applied to the measurement was made, comparing the results obtained with the Static Magnetic Barkhausen Noise (SMBN) technique, which is a method already established in the literature. The results showed that in all cases studied it was possible to detect the position of the damage, due to variation of the magnetic field. These changes are affected by the presence and distribution of elastic stresses (compression and traction), plastic deformation and microstructure modification. The results of CSMBN were similar to the SBMN with the advantage of being a continuous and more productive procedure. This new technique increases the spectrum of NDIT solutions for problems not contemplated by existing techniques.
DOI: 10.6084/m9.figshare.7591445.v1
title: Influence of Copper and Metallic Alloys on the Oxidation Reaction of Commercial Biodiesel in Mixture with Natural Antioxidant

description: The purpose of this research was to evaluate the influence of metallic alloys and copper in the degradation of biodiesel in mixture with blackberry extract. Biodiesel is formed by unsaturated esters highly susceptible to the oxidation reaction. The initial induction period (IP) of the control sample was 9.53 h and, after 208 days, the IP reduced to 5.74 h. However, with the addition of the antioxidant, the final IP was 6.27 h. The assays involving carbon steel, stainless steel, silver steel and copper showed final IP of 3.78, 4.43, 1.59 and 0.09 h, respectively. This behavior indicates that the reaction was catalyzed in the presence of metal. The addition of the blackberries extract favored the increase of the induction period and the decrease of the reaction rate constant values, aside from the carbon steel that presented a final IP of 1.22 h. The highest rate constant was 7.41 h obtained for biodiesel in contact with copper, as well as the highest IP. The acid number ranged from 0.34 to 0.60 mgKOH g-1. It was possible to observe in the oxidation reactions the presence of the linearity deviation proposed by Arrhenius.
DOI: 10.7284/115586
title: Gravimeter data collected during research cruise FK140418 using a Bell BGM-3 instrument system onboard the platform RV Falkor

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7591439.v1
title: Investigation of VEGF gene polymorphism rs35569394 in endometriosis

description: ABSTRACT Introduction: Endometriosis is a chronic gynecological condition characterized by the presence of endometrial tissue in locations outside the uterus. Its symptoms include dysmenorrhea, dyspareunia, chronic pelvic pain, infertility, dysuria, and dyschezia. Several studies have related the vascular endothelial growth factor (VEGF) gene polymorphisms as a factor for the development of endometriosis. Objectives: The aim of this study was to compare the frequency of the VEGF gene polymorphism rs35569394 in women with endometriosis and a control group, as well as to investigate the association of this polymorphism with the risk of endometriosis. Methods: This case-control study included 45 endometriosis patients (cases) and 78 controls. The molecular analysis was performed by polymerase chain reaction (PCR). The chi-square test was used to compare the genotype and allele frequencies, and the Hardy-Weinberg equilibrium was also tested using the chi-square test, considering the significance of p &lt; 0.05. Results: The frequency of the II, ID and DD genotype was 24.4% versus 26.9%; 35.6% versus 37.2%; and 40% versus 35.9%, in patients and the control group, respectively. The allele frequencies were I: 0.42 (cases) and 0.45 (control); D: 0.58 (cases) and 0.55 (control). The allele and genotype frequency of VEGF -2549I/D polymorphism was not different between women with endometriosis and the control. Conclusion: In the present study, the frequency of the VEGF gene polymorphism rs35569394 is similar between cases and control. This genetic variant is not associated with endometriosis in the investigated population.
DOI: 10.6084/m9.figshare.7591442.v1
title: Continuous Scanning Technique with Barkhausen Magnetic Noise for Carbon Steel Sheets

description: This work studies the application of a Non-Destructive Inspection Technique (NDIT), based on the Magnetic Barkhausen Noise (MBN), for the detection of non-homogeneous regions in carbon steel plates. It presents the advances in the development of a variant of a new non-destructive magnetic test technique, called Continuous Scanning Magnetic Barkhausen Noise (CSMBN). The non-homogeneous or damaged regions were produced by plastic deformations in rolled and annealed sheets of SAE 1060 and 1070 steels. MBN is generated by abrupt changes in the magnetization of materials when subjected to alteration. The sensitivity of the MBN signals in the detection of plastic deformations was analyzed varying parameters such as excitation magnetic field frequency and the speed of movement of the probe. The behavior of the root mean square of magnetic Barkhausen Noise signal (RMSMBN) parameter was correlated with the position of the nonhomogeneous regions detected in the samples. An evaluation of the technique applied to the measurement was made, comparing the results obtained with the Static Magnetic Barkhausen Noise (SMBN) technique, which is a method already established in the literature. The results showed that in all cases studied it was possible to detect the position of the damage, due to variation of the magnetic field. These changes are affected by the presence and distribution of elastic stresses (compression and traction), plastic deformation and microstructure modification. The results of CSMBN were similar to the SBMN with the advantage of being a continuous and more productive procedure. This new technique increases the spectrum of NDIT solutions for problems not contemplated by existing techniques.
DOI: 10.6084/m9.figshare.7591433
title: Argentina, where are you from? Performative and pedagogical strategies to tackle racism

description: Abstract: We present the development of a communicative and pedagogical device to address ethnic-racial discrimination in school environments. We work at High School No. 518 Carlos Fuentealba, in one of the neighborhoods with the largest Qom population in the city of Rosario (Argentina). The device, designed to guide academic and artistic research, uses performance as a methodological tool to investigate the African-Argentinean legacy and activate latent perceptions related to racism, a hidden and silenced issue in our country.
DOI: 10.7284/118980
title: Gyrocompass data collected during research cruise FK140418 using a Raytheon STD 22 instrument system onboard the platform RV Falkor

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7591430
title: Synthesis, Antimicrobial Activity and Structure-Activity Relationship of Some 5-Arylidene-thiazolidine-2,4-dione Derivatives

description: Derivatives of the thiazolidine-2,4-dione core represent a heterocyclic class with several correlated properties. In this context, the synthesis of structural analogues of these bioactive substances becomes attractive in the field of medicinal chemistry. These analogues act as antimicrobial agents against Gram-positives pathogens. The present work aimed to synthesize 10 different derivatives of 5-arylidene-thiazolidine-2,4-dione, employing urea as the catalyst in a solvent-free reaction medium, with yields that ranged from 45 to 99%. The compounds obtained were submitted to an antimicrobial assay against S. aureus ATCC 29213. Two compounds presented minimum inhibitory concentration of 62.5 and 32.5 µg mL-1 and minimum bactericidal concentration &lt; 500 µg mL-1, demonstrating their antibacterial potential. Principal component analysis was carried out to discriminate the compounds in active and inactive classes. Four geometric and electronic molecular descriptors were required to completely discriminate the compounds. The selected descriptors can guide us in designing new 5-arylidene-thiazolidine-2,4-dione derivatives with enhanced activity.
DOI: 10.6084/m9.figshare.7591433.v1
title: Argentina, where are you from? Performative and pedagogical strategies to tackle racism

description: Abstract: We present the development of a communicative and pedagogical device to address ethnic-racial discrimination in school environments. We work at High School No. 518 Carlos Fuentealba, in one of the neighborhoods with the largest Qom population in the city of Rosario (Argentina). The device, designed to guide academic and artistic research, uses performance as a methodological tool to investigate the African-Argentinean legacy and activate latent perceptions related to racism, a hidden and silenced issue in our country.