cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.60712/si-id42645.1
title: StrainInfo SI-ID 42645.1

description: StrainInfo dataset 42645 about a strain of Corynebacterium accolens. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id42646.1
title: StrainInfo SI-ID 42646.1

description: StrainInfo dataset 42646 about a strain of Micrococcus luteus. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.6084/m9.figshare.26056969
title: <b>Cathepsin S (CTSS) in IgA Nephropathy: An Exploratory Study on Its Role as a Potential Diagnostic Biomarker and Therapeutic Target</b>

description: We conducted a comprehensive bidirectional and multivariable Mendelian randomization (MR) study using publicly available genetic data to explore the causal association between cathepsins and IgA nephropathy (IgAN), systematically. Additionally, immunohistochemical (IHC) staining and enzyme-linked immunosorbent assay (ELISA) were employed to evaluate cathepsin expression levels in renal tissues and serum of IgAN patients. We investigated the underlying mechanisms via gene set variation analysis (GSVA), gene set enrichment analysis (GSEA), and immune cell infiltration analysis. Molecular docking and virtual screening were also performed to identify potential drug candidates through drug repositioning.Univariate MR analyses demonstrated a significant link between increased cathepsin S (CTSS) levels and a heightened risk of IgAN. This was evidenced by an odds ratio (OR) of 1.041 (95% CI=1.009–1.073, <i>P</i>=0.012) as estimated using the inverse variance weighting (IVW) method. In multivariable MR analysis, even after adjusting for other cathepsins, elevated CTSS levels continued to show a strong correlation with an increased risk of IgAN (IVW <i>P</i>=0.020, OR=1.037, 95% CI=1.006–1.069). However, reverse MR analyses did not establish a causal relationship between IgAN and various cathepsins. IHC and ELISA findings revealed significant overexpression of CTSS in both renal tissues and serum of IgAN patients compared to controls, and this high expression was unique to IgAN compared with several other primary kidney diseases such as membranous nephropathy, minimal change disease and focal segmental glomerulosclerosis. Investigations into immune cell infiltration, GSEA, and GSVA highlighted the role of CTSS expression in the immune dysregulation observed in IgAN. Molecular docking and virtual screening pinpointed Camostat mesylate, c-Kit-IN-1, and Mocetinostat as the top drug candidates for targeting CTSS.
DOI: 10.15468/dl.wqmlaw
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is Ecuador",
 "Issue is Geodetic datum assumed WGS84",
 {
 "or" : [
 "Month is January",
 "Month is February",
 "Month is March",
 "Month is April",
 "Month is May",
 "Month is June",
 "Month is July",
 "Month is August",
 "Month is September",
 "Month is October",
 "Month is November",
 "Month is December"
 ]
 },
 "Year 1960-1979",
 "Geometry POLYGON((-81.36475 -5.7909,-74.99268 -5.7909,-74.99268 2.19673,-81.36475 2.19673,-81.36475 -5.7909))",
 "HasCoordinate is true",
 "HasGeospatialIssue is false"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0045980-180508205500799/datasets/export for details.
DOI: 10.60712/si-id42707.1
title: StrainInfo SI-ID 42707.1

description: StrainInfo dataset 42707 about a strain of Pseudomonas. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.6084/m9.figshare.26056969.v1
title: Raw_Data.zip

description: We conducted a comprehensive bidirectional and multivariable Mendelian randomization (MR) study using publicly available genetic data to explore the causal association between cathepsins and IgA nephropathy (IgAN), systematically. Additionally, immunohistochemical (IHC) staining and enzyme-linked immunosorbent assay (ELISA) were employed to evaluate cathepsin expression levels in renal tissues and serum of IgAN patients. We investigated the underlying mechanisms via gene set variation analysis (GSVA), gene set enrichment analysis (GSEA), and immune cell infiltration analysis. Molecular docking and virtual screening were also performed to identify potential drug candidates through drug repositioning.Univariate MR analyses demonstrated a significant link between increased cathepsin S (CTSS) levels and a heightened risk of IgAN. This was evidenced by an odds ratio (OR) of 1.041 (95% CI=1.009–1.073, <i>P</i>=0.012) as estimated using the inverse variance weighting (IVW) method. In multivariable MR analysis, even after adjusting for other cathepsins, elevated CTSS levels continued to show a strong correlation with an increased risk of IgAN (IVW <i>P</i>=0.020, OR=1.037, 95% CI=1.006–1.069). However, reverse MR analyses did not establish a causal relationship between IgAN and various cathepsins. IHC and ELISA findings revealed significant overexpression of CTSS in both renal tissues and serum of IgAN patients compared to controls, and this high expression was unique to IgAN compared with several other primary kidney diseases such as membranous nephropathy, minimal change disease and focal segmental glomerulosclerosis. Investigations into immune cell infiltration, GSEA, and GSVA highlighted the role of CTSS expression in the immune dysregulation observed in IgAN. Molecular docking and virtual screening pinpointed Camostat mesylate, c-Kit-IN-1, and Mocetinostat as the top drug candidates for targeting CTSS.
DOI: 10.60712/si-id42708.1
title: StrainInfo SI-ID 42708.1

description: StrainInfo dataset 42708 about a strain of Synergistes jonesii. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id42709.1
title: StrainInfo SI-ID 42709.1

description: StrainInfo dataset 42709 about a strain of Staphylococcus aureus subsp. aureus. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id42710.1
title: StrainInfo SI-ID 42710.1

description: StrainInfo dataset 42710 about a strain of Borrelia anserina. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.15468/dl.aqxiqa
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "DatasetKey" : [
 "is A global database for the distributions of crop wild relatives"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0046210-180508205500799/datasets/export for details.
DOI: 10.60712/si-id42647.1
title: StrainInfo SI-ID 42647.1

description: StrainInfo dataset 42647 about a strain of Haemophilus felis. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id42765.1
title: StrainInfo SI-ID 42765.1

description: StrainInfo dataset 42765 about a strain of Mycobacterium brisbanense. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id42648.1
title: StrainInfo SI-ID 42648.1

description: StrainInfo dataset 42648 about a strain of Haemophilus felis. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id42649.1
title: StrainInfo SI-ID 42649.1

description: StrainInfo dataset 42649 about a strain of Haemophilus felis. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.15468/dl.xzubtn
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{ }

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0046546-180508205500799/datasets/export for details.
DOI: 10.60712/si-id42650.1
title: StrainInfo SI-ID 42650.1

description: StrainInfo dataset 42650 about a strain of Streptomyces griseus subsp. griseus. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id42711.1
title: StrainInfo SI-ID 42711.1

description: StrainInfo dataset 42711 about a strain of Pseudomonas fluorescens. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id42713.1
title: StrainInfo SI-ID 42713.1

description: StrainInfo dataset 42713 about a strain of Saccharopolyspora taberi. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id42714.1
title: StrainInfo SI-ID 42714.1

description: StrainInfo dataset 42714 about a strain of Kibdelosporangium philippinense. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id42716.1
title: StrainInfo SI-ID 42716.1

description: StrainInfo dataset 42716 about a strain of Rubrivivax gelatinosus. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id42766.1
title: StrainInfo SI-ID 42766.1

description: StrainInfo dataset 42766 about a strain of Mycobacterium porcinum. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id42767.1
title: StrainInfo SI-ID 42767.1

description: StrainInfo dataset 42767 about a strain of Campylobacter coli. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id42768.1
title: StrainInfo SI-ID 42768.1

description: StrainInfo dataset 42768 about a strain of Arcobacter butzleri. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id42769.1
title: StrainInfo SI-ID 42769.1

description: StrainInfo dataset 42769 about a strain of Halanaerobacter lacunarum. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id42651.1
title: StrainInfo SI-ID 42651.1

description: StrainInfo dataset 42651 about a strain of Streptomyces anulatus. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id42652.1
title: StrainInfo SI-ID 42652.1

description: StrainInfo dataset 42652 about a strain of Solidesulfovibrio alcoholivorans. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id42653.1
title: StrainInfo SI-ID 42653.1

description: StrainInfo dataset 42653 about a strain of Bacillus. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id42717.1
title: StrainInfo SI-ID 42717.1

description: StrainInfo dataset 42717 about a strain of Aeromonas hydrophila. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id42718.1
title: StrainInfo SI-ID 42718.1

description: StrainInfo dataset 42718 about a strain of Pluralibacter pyrinus. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id42719.1
title: StrainInfo SI-ID 42719.1

description: StrainInfo dataset 42719 about a strain of Laceyella putida. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.15468/dl.anfygh
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Tracheophyta"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0047498-180508205500799/datasets/export for details.
DOI: 10.60712/si-id42770.1
title: StrainInfo SI-ID 42770.1

description: StrainInfo dataset 42770 about a strain of Leptospira kirschneri. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id42771.1
title: StrainInfo SI-ID 42771.1

description: StrainInfo dataset 42771 about a strain of Erwinia amylovora. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id42772.1
title: StrainInfo SI-ID 42772.1

description: StrainInfo dataset 42772 about a strain of Morganella morganii subsp. sibonii. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id42654.1
title: StrainInfo SI-ID 42654.1

description: StrainInfo dataset 42654 about a strain of Staphylococcus epidermidis. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id42655.1
title: StrainInfo SI-ID 42655.1

description: StrainInfo dataset 42655 about a strain of Erwinia persicina. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id42656.1
title: StrainInfo SI-ID 42656.1

description: StrainInfo dataset 42656 about a strain of Allorhizobium vitis. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id42657.1
title: StrainInfo SI-ID 42657.1

description: StrainInfo dataset 42657 about a strain of Propionibacterium. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.15468/dl.hheljg
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{ }

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0048059-180508205500799/datasets/export for details.
DOI: 10.60712/si-id42720.1
title: StrainInfo SI-ID 42720.1

description: StrainInfo dataset 42720 about a strain of Thermoflavimicrobium dichotomicum. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id42721.1
title: StrainInfo SI-ID 42721.1

description: StrainInfo dataset 42721 about a strain of Saccharopolyspora hordei. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id42723.1
title: StrainInfo SI-ID 42723.1

description: StrainInfo dataset 42723 about a strain of Streptomyces tubercidicus. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id42773.1
title: StrainInfo SI-ID 42773.1

description: StrainInfo dataset 42773 about a strain of Fibrobacter intestinalis. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id42774.1
title: StrainInfo SI-ID 42774.1

description: StrainInfo dataset 42774 about a strain of Staphylococcus aureus subsp. aureus. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id42775.1
title: StrainInfo SI-ID 42775.1

description: StrainInfo dataset 42775 about a strain of Xylella fastidiosa. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id42776.1
title: StrainInfo SI-ID 42776.1

description: StrainInfo dataset 42776 about a strain of Listeria ivanovii subsp. londoniensis. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id42658.1
title: StrainInfo SI-ID 42658.1

description: StrainInfo dataset 42658 about a strain of Thiothrix unzii. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id42724.1
title: StrainInfo SI-ID 42724.1

description: StrainInfo dataset 42724 about a strain of Mycobacterium madagascariense. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id42725.1
title: StrainInfo SI-ID 42725.1

description: StrainInfo dataset 42725 about a strain of Bacillus. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id42726.1
title: StrainInfo SI-ID 42726.1

description: StrainInfo dataset 42726 about a strain of Guyparkeria halophila. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id42727.1
title: StrainInfo SI-ID 42727.1

description: StrainInfo dataset 42727 about a strain of Nocardia asteroides. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id42728.1
title: StrainInfo SI-ID 42728.1

description: StrainInfo dataset 42728 about a strain of Nocardia wallacei. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id42777.1
title: StrainInfo SI-ID 42777.1

description: StrainInfo dataset 42777 about a strain of Corynebacterium. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id42778.1
title: StrainInfo SI-ID 42778.1

description: StrainInfo dataset 42778 about a strain of Roseomonas gilardii subsp. gilardii. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id42779.1
title: StrainInfo SI-ID 42779.1

description: StrainInfo dataset 42779 about a strain of Roseomonas cervicalis. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id42780.1
title: StrainInfo SI-ID 42780.1

description: StrainInfo dataset 42780 about a strain of Roseomonas. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.