cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.24025749
title: Supplementary Material for: Calcium-citrate anticoagulation during continuous renal replacement therapy in patients with metformin intoxication: a case series, mathematical estimation of citrate accumulation and literature review.

description: Background. Metformin intoxication causes lactic acidosis by inhibiting Krebs' cycle and oxidative phosphorylation. Continuous renal replacement therapy (CRRT) is recommended for metformin removal in critically ill patients. According to current guidelines, regional citrate anticoagulation (RCA) is the first-line strategy. However, since metformin also inhibits citrate metabolism, a risk of citrate accumulation could be hypothesized. Objectives. In the present study, we monitored the potential citrate accumulation in metformin-associated lactic acidosis (MALA) patients treated with CRRT and RCA using the physical-chemical approach to acid-base interpretation. Material and Methods. We collected a case series of three patients with MALA. Patients were treated with continuous venovenous hemofiltration (CVVH), and RCA was performed with diluted citrate solution. Citrate accumulation was monitored through two methods: the ratio between total and ionized plasma calcium concentrations (T/I calcium ratio) above 2.5 and the strong ion gap (SIG) to identify an increased concentration of unmeasured anions (UA). Lastly, a mathematical model was developed to estimate the expected citrate accumulation during CVVH and RCA. Results. All three patients showed a resolution of MALA after the treatment with CVVH. The T/I calcium ratio was consistently below 2.5, and SIG decreased, reaching values lower than 6 mEq/L after 48h of CVVH treatment. According to the mathematical model, the estimated SIG without citrate metabolism should have been around 21 mEq/L due to citrate accumulation. Conclusions. In our clinical management, no signs of citrate accumulation were recorded in MALA patients during treatment with CVVH and RCA. Our data support the safe use of diluted citrate to perform RCA during metformin intoxication.
DOI: 10.6084/m9.figshare.24071187
title: Supplementary Material for: Semi-autologous Corneal Transplantation with Simultaneous Bilateral Surgery: A Case Report

description: The present report describes a case of semi-autologous corneal transplantation with bilateral surgery using two operating microscopes simultaneously. An 86-year-old man with history of six prior failed penetrating keratoplasties in his right eye presented with decreased vision. His other eye was deeply amblyopic but had a clear 30-year-old Castroviejo square graft with an endothelial cell count of 803 cells/mm2. A semi-autologous graft was performed from the left eye to the right. Surgery was performed simultaneously on both eyes by two different surgeons using a standard ophthalmic operating microscope as well as a second ENT microscope. Upon trephination of the right failed corneal graft, vitreous opacities were noted and sent for culture. The semi-autologous tissue was directly transferred from the left eye to the right without any storage in preservation media to avoid endothelial cell loss. The semi-autologous graft remained clear in the immediate post-operative period. However, the vitreous cultures grew coagulase negative Staphylococcus. Despite all efforts, the patient eventually developed a retinal detachment and vision in the right eye decreased to light perception. Autologous penetrating keratoplasty is an option for patients with loss of corneal function in a potentially seeing eye and a clear cornea in a contralateral eye with poor visual potential due to non-corneal disease. This case is unique in that part of the autologous penetrating keratoplasty had an old square graft in the center and corneal transplant surgery was done simultaneously in both eyes. It also highlights chronic indolent endophthalmitis as a potential cause of multiple graft failures.
DOI: 10.6084/m9.figshare.24071211
title: Supplementary Material for: A case of binocular metastatic choroidal tumor originating from pulmonary adenocarcinoma successfully treated with molecular target therapy

description: The occurrence of ocular metastasis from lung cancer is uncommon. In our current case, we report on a 64-year-old male patient found to have metastatic lesions in both choroids after being diagnosed with lung adenocarcinoma. As the patient was found to have a mutation in the epidermal growth factor receptor (EGFR), he was treated with the EGFR tyrosine kinase inhibitor (EGFR TKI), afatinib. However, the treatment response suggested the presence of a progressive disease. Thus, due to cancerous meningitis, the patient’s treatment was changed from afatinib to erlotinib, in addition to adding bevacizumab. Although the general condition of the patient did not change, improvement was noted for the choroidal metastasis. Moreover, the drug change also resulted in an improvement of the visual power of both eyes. Therefore, the results for this patient suggest that systemic administration of erlotinib and bevacizumab may be an effective treatment that leads to morphological and functional improvement in choroidal metastasis cases.
DOI: 10.6084/m9.figshare.24203832
title: Supplementary Material for: Berlin’s Edema with Atypical Optical Coherence Tomography Findings: a case report

description: Berlin’s edema is an acute traumatic maculopathy following ocular blunt trauma, with the major site of injury is photoreceptor outer segments and retinal pigment epithelium (RPE). Optical coherence tomography (OCT) is a useful tool to diagnose and follow microstructural changes in Berlin’s edema. In this report, we present an atypical case of berlin’s edema that resembled Vogt-Koyanagi-Harada (VKH) disease. OCT demonstrated multiple neurosensory detachments and giant cystic changes of outer retina. Fluorescein angiography showed no dye leakage or vascular alterations. The patient was treated with a short period of topical and systemic corticosteroids and she improved significantly within a few weeks.
DOI: 10.6084/m9.figshare.24212013
title: Supplementary Material for: Novel surgical treatment of an intraretinal juxtapapillary hemangioblastoma using intraocular diathermy forceps: A case report

description: The surgical treatment of intraretinal juxtapapillary retinal hemangioblastomas (JRHs) was previously not indicated because of the high risk of collateral damage to the macula and optic nerve. This case report discusses the effectiveness and safety of a novel surgical technique using intraocular bipolar diathermy forceps to coagulate feeder and draining blood vessels of an intraretinal JRH. The patient suffered from bilateral retinal hemangioblastomas with loss of function in one eye and the development of an intraretinal JRH in the other eye. Despite intensive treatment with intravitreal bevacizumab and subconjunctival triamcinolone acetonide, growth of the intraretinal JRH continued, macular exudation worsened, and visual acuity decreased. Surgical treatment was undertaken in which, first, the feeder and draining vessels of the JRH were identified by comparing the retinal imaging of the JRH with the imaging before the emergence of the JRH four years earlier. Then, retinal incisions were made above the blood vessels and parallel to the nerve fibers during a pars plana vitrectomy. Lastly, these vessels were lifted above the retinal surface and coagulated using intraocular diathermy forceps. Postoperatively, macular edema reduced, and visual acuity increased and remained stable for about six months. Using intraocular diathermy forceps, this case report demonstrates effective and safe intraretinal JRH blood vessel coagulation above the retinal surface. This novel surgical approach was able to delay the deterioration of visual acuity due to tumor growth and exudation in this patient. This suggests that coagulation with intraocular diathermy forceps can be considered an additional surgical treatment option for JRHs, especially those with an intraretinal growth pattern.
DOI: 10.6084/m9.figshare.24235036
title: Supplementary Material for: Management of Large conjunctival cysts in a patient with Stevens-Johnson syndrome; a case report and review of the literature

description: Stevens-Johnson syndrome (SJS) is a life-threatening mucocutaneous disease with various etiologies including drugs, infections, and malignancies. Ocular manifestations of SJS vary from the membrane, symblepharon formation, and epithelial defect in the acute phase to trichiasis, eyelid margin keratinization, and lacrimal duct obstruction in the chronic phase. A 13-year-old boy with a history of drug-induced SJS presented to our clinic complaining of a mass in the nasal side and inferior fornix of the right eye from 1 year ago. The mass-like lesion in the medial side of the right eye was accompanied by ankyloblepharon, symblepharon, and ptosis and limited ocular movement. Orbital imaging showed cystic lesions on the medial side of the right globe and the inferior fornix. Two large cysts were entirely surgically excised. Histopathologic investigation revealed conjunctival tissue with nonkeratinized epithelium and goblet cells. There was no sign of conjunctival cyst recurrence or symblepharon formation on the 6th-month follow-up. The inferior fornix achieved acceptable depth and the ocular movements became normal. As a result, spontaneous conjunctival cysts may occur in SJS and should be managed carefully to improve the ocular surface and movements.
DOI: 10.6084/m9.figshare.24278101
title: One-year dataset of hourly air quality parameters from 100 air purifiers used in China residential buildings

description: Household air purifiers have been widely used as an effective approach to improving indoor air quality. Air purifiers can automatically record indoor air quality parameters, providing valuable data resources for in-depth data-driven analysis. This work presents a one-year hourly indoor air quality dataset collected by household air purifiers in 100 residential homes in 18 provinces across 4 different climate zones in China. The data were collected from July 1, 2021, to July 1, 2022. The concentrations of formaldehyde, PM<sub>2.5</sub>, TVOC, temperature, relative humidity, on/off status and the airflow rate of air purifiers during operations were recorded hourly.
DOI: 10.5281/zenodo.7646220
title: Transposons are a major contributor to gene expression variability under selection in rice populations

description: Dataset and code related to the publication: Castanera R., Morales-Díaz N., Gupta S., Purugganan M., Casacuberta JM (2022). Transposons are a major contributor to gene expression variability under selection in rice populations. Research Square. https://doi.org/10.21203/rs.3.rs-2197876/v1. <br> 1) TIP_data folder: INDICA_teinsertions_5_2_2_matrix_sorted_ID_MAF003.txt: TIP matrix used for TIP-eQTL mapping (binary form, where 0 = absence, 1= presence)<br> INDICA_teinsertions_5_2_2_matrix_sorted_ID_MAF003.info: TIP information (chrom,start,superfamily,family,maf)<br> JAPONICA_teinsertions_5_2_2_matrix_sorted_ID_MAF003.txt: TIP matrix used for TIP-eQTL mapping (binary form, where 0 = absence, 1= presence)<br> JAPONICA_teinsertions_5_2_2_matrix_sorted_ID_MAF003.info:TIP information (chrom,start,superfamily,family,maf) <br> 2) SNP_data folder: SNP_matrix_final_IRGC_Indica_MAF003.lfmm: SNP binary matrix used for TIP-eQTL mapping <br> SNP_matrix_final_IRGC_Indica_MAF003.info: SNP information<br> SNP_matrix_final_IRGC_japonica_MAF003.lfmm: SNP binary matrix used for TIP-eQTL mapping <br> SNP_matrix_final_IRGC_japonica_MAF003.info:SNP information 3) Expression data: Normalized expression data and accessory files used for TIP-eQTL analysis (as described in TIP-eQTL_matrix.R) Code: PopoolationTE2.sh: Bash script to reproduce PopoolationTE2 analysis (TIP detection) TIP-eQTL_matrix.R: R code to reproduce eQTL analyses
DOI: 10.5281/zenodo.8273030
title: Dataset from 'Influence of anthropogenic emissions on the composition of highly oxygenated organic molecules in Helsinki: a street canyon and urban background station comparison'

description: This dataset supplements the following manuscript: Okuljar, M., Garmash, O., Olin, M., Kalliokoski, J., Timonen, H., Niemi, J. V., Paasonen, P., Kontkanen, J., Zhang, Y., Hellén, H., Kuuluvainen, H., Aurela, M., Manninen, H. E., Sipilä, M., Rönkkö, T., Petäjä, T., Kulmala, M., Dal Maso, M., and Ehn, M.: Influence of anthropogenic emissions on the composition of highly oxygenated organic molecules in Helsinki: a street canyon and urban background station comparison, EGUsphere [preprint], https://doi.org/10.5194/egusphere-2023-524, 2023.
DOI: 10.5281/zenodo.8361378
title: Dataset for the Cost of Living Index as a Primary Driver of Homelessness

description: SPSS data file SPSS output file Excel data and sources file Excel data only file for use with python processing (program on Github and archived on Zenodo)
DOI: 10.5445/ir/1000156935
title: IMK-IAA MIPAS V5 data set of ClONO2, HNO3, HOCl, N2O5, NO, NO2, and O3 vertical profiles and corresponding averaging kernel matrices for October and November 2003
DOI: 10.6084/m9.figshare.19170041.v2
title: Final_Pandemic_Study.xlsx

description: Pandemic Pedagogy: Perception of Nursing Students
DOI: 10.6084/m9.figshare.20934613
title: Machine Learning Model to Predict Endophytic Colonisation of Rice Cultivar Plant Tissues by Beauveria Bassiana Isolates and their Potential as Bio-control Agents Against Rice Stem Borer using Existing Knowledge.

description: <strong>Dataset 1. </strong> <br> <strong>Evaluation of endophytic behaviour of </strong><em><strong>B. bassiana </strong></em><strong>strains in rice plants following seed inoculation.</strong> <br> <br> <strong>Dataset 2. </strong> <br> <strong>Evaluation of endophytic behaviour of </strong><em><strong>B. bassiana </strong></em><strong>strains in rice plants following foliar spray inoculation.</strong> <br> <br> <br>
DOI: 10.6084/m9.figshare.21324612
title: Supplementary Material for: Dietary Folate, Vitamin B6 and Vitamin B12 and Risk of Cardiovascular Diseases among Individuals with Type 2 Diabetes: a Case-Control Study

description: Background: Emerging evidence suggests that dietary one-carbon metabolism-related B-vitamins are associated with the reduced risk of cardiovascular disease (CVD) in general populations. However, only a few studies have assessed their associations in patients with type 2 diabetes (T2D). Objective: This study aims to assess the associations between the intake of three one-carbon metabolism-related B-vitamins (folate, vitamin B6 and vitamin B12) and CVD risk in Chinese patients with T2D. Methods: A hospital-based case–control study of 419 patients with T2D and newly diagnosed CVD and 419 age- (±5 years) and sex-matched T2D-only controls was carried out in China. A validated 79-item semiquantitative food-frequency questionnaire administered in face-to-face interviews was used to measure dietary B-vitamin intake. Conditional logistic regression was used to assess associations, which were tested by estimating odds ratios (ORs) with 95% confidence intervals (CIs). Results: Compared with the lowest quartile, the multivariable-adjusted ORs and 95% CIs for highest quartile were 0.32 (95% CI 0.20, 0.52; P-trend &lt; 0.001) for folate, 0.47 (95% CI 0.30, 0.76; P-trend = 0.002) for vitamin B6 and 1.02 (95% CI 0.67, 1.55; P-trend = 0.841) for vitamin B12. Consistent inverse associations were found for folate intake from eggs, vegetables, fruits, soy and other foods but not for folate intake from grains. Conclusions: Findings suggest that the high consumption of folate and vitamin B6, but not that of vitamin B12, might be associated with the low risk of CVD in patients with T2D. This study suggests that dietary folate and vitamin B6 protect against CVD in patients with T2D.
DOI: 10.6084/m9.figshare.21674363
title: Supplementary Material for: A multidisciplinary evaluation for advanced supportive care of breast cancer patients

description: Background: The prevalence of cancer is increasing, and this is the consequence of the rising incidence of tumours but also of the more effective treatments received. This implies that there are more and more persons that receive medical anticancer therapies and that are interested in maintaining their quality of life. Many oncological treatments, including chemotherapy, immunotherapy, surgery and radiotherapy, and combined therapy are associated with cutaneous toxicity. This is particularly relevant when new therapies are used since these may cause new and unexpected side effects that may be short-lived but, in some cases, may become chronic or permanent. Patients often seek advice with their oncologists on what can be done and what cannot be done. Notably, many of the cutaneous side effects can be prevented or reduced by adequate interventions. Summary: The aim of this review is to highlight how oncological patients may benefit from a closer collaboration between specialists in different branches. We will focus on women with breast cancer since we think that they may derive a special benefit from this collaboration, but we will analyse other cancers in future papers. Key Messages: The working group was created with two specific aims: to help the oncologist in the prevention and management of cutaneous toxicity and to support patients in this phase of their lives, including nutritional assessment and dietary support.
DOI: 10.6084/m9.figshare.21820260
title: Supplementary Material for: A Rare Pathogenic Variant in the <b><i>SERPINF1</i></b> Gene in Association with Early-Onset Severe Presentation of Autosomal Recessive Type of Osteogenesis Imperfecta VI: A Case Report

description: Osteogenesis imperfecta (OI) refers to a group of genetic disorders with the typical clinical presentation of increased bone fragility. More than 90% of OI cases have an underlying genetic mutation in the collagen genes <i>COL1A1</i> or <i>COL1A2</i>. However, there are now 22 different recognized OI subtypes based on the underlying gene implicated. OI type VI is caused by pathogenic variants in the serine proteinase inhibitor clade F (<i>SERPINF1</i>) gene. In this case study, the patient was a 4-year-old female, born in a consanguineous family, with a history of delayed gross motor milestones and recurrent fractures after trivial trauma since the age of 8 months. The results of skeletal surveys and bone scans indicated that the patient suffered from OI. To confirm the diagnosis, we performed a next-generation sequencing (NGS) analysis of genes implicated in OI using the TruSight One NGS Panel. Bioinformatics analysis showed the presence of a rare pathogenic variant in exon 7 of the <i>SERPINF1</i> gene in a homozygous state (NM_002615.5:c.907C&gt;T; NP_002606.3:p.Arg303Ter; ClinVar submission ID: SUB10491966). The variant results in the termination of the polypeptide chain at position 303. Targeted capillary sequencing confirmed the presence of this variant in a homozygous state in the patient and in heterozygous state for both parents. Additionally, the patient’s younger sibling, aged 10 months, harbored the variant in a homozygous state. The sibling started bisphosphonate therapy and did not suffer any fractures in over 2 years after initiating the therapy. The etiological genetic diagnosis helped provide genetic counseling to the family. This highlights the utility of NGS for the confirmation of a clinical analysis in cases where alterations in multiple genes can result in similar clinical presentation.
DOI: 10.6084/m9.figshare.21820647
title: Supplementary Material for: Favorable Outcome with Intravenous Immunoglobulin Therapy in Late-Onset Anti-mGluR1 Encephalitis: A Case Report and Literature Review

description: Anti-metabotropic glutamate receptor 1 (mGluR1) encephalitis is a rare autoimmune disorder manifesting with cerebellar syndrome. Patients with mGluR1 encephalitis have been treated with immunomodulatory therapies; however, little is known about the efficacy of this therapy. A 58-year-old Japanese woman presented with dizziness when walking and standing up. Symptoms persisted and the patient gradually deteriorated. The neurological examination revealed a broad-based gait, horizontal and slightly gaze-evoked nystagmus, noticeable head titubation, and truncal ataxia without limb ataxia. Magnetic resonance imaging was normal. The <sup>123</sup>I-isopropyl-iodoamphetamine single-photon emission-computed tomography scans showed normal cerebellar perfusion. Based on a positive antibody test for anti-mGluR1, the patient was diagnosed with anti-mGluR1 encephalitis. She was treated with intravenous methylprednisolone and intravenous immunoglobulin (IVIg). Symptoms gradually improved over 1 month and almost disappeared after additional IVIg therapy. Anti-mGluR1 encephalitis is a rare disease, and effective treatment is unclear. In this case, a favorable outcome was obtained with immunomodulatory therapy, even though the neurological disability of the disease course is worse. We emphasize the importance of early diagnosis and therapeutic intervention, suspecting the disease on the basis of its characteristic symptoms.
DOI: 10.6084/m9.figshare.21864582
title: Supplementary Material for: Endoscopic Ligation with O-Ring Closure for Mucosal Defects after Rectal Endoscopic Submucosal Dissection: A Feasibility Study (with Video)

description: <b><i>Introduction:</i></b> Mucosal defect closure after colorectal endoscopic submucosal dissection (ESD) may prevent post-ESD adverse events. Delayed bleeding is a particular concern in the rectum due to the presence of numerous blood vessels. However, rectal defect closure often fails due to the thick rectal wall. This study aimed to examine the feasibility of our newly developed endoscopic ligation with O-ring closure (E-LOC) for defects after rectal ESD. <b><i>Methods:</i></b> This was a prospective observational study conducted at a single institution. After excluding 2 patients with tumors mostly extending into the anal canal, the study cohort comprised 30 consecutive patients who underwent ESD of rectal neoplasms between July 2020 and July 2021. E-LOC using an endoscopic variceal ligation device was performed for closing mucosal defects after rectal ESD. The primary outcome was the complete closure rate. The secondary outcomes were the delayed bleeding rate, E-LOC procedure time, sustained closure rates on postoperative day (POD) 3, and E-LOC-associated complications. <b><i>Results:</i></b> Complete closure of the defect (median defect size 29.0 mm) was successfully achieved in 24 cases (80%). Delayed bleeding occurred in one case with incomplete closure (3.3%). The median E-LOC procedure time was 25.5 min (interquartile range, 20.0–30.0 min). The sustained closure rates were 83.3% (20/24) on POD 3 in the 24 cases with complete closure. No E-LOC-associated complications occurred. <b><i>Discussion/Conclusions:</i></b> E-LOC was feasible for defect closure after rectal ESD, and probably led to a decreased incidence of delayed bleeding.