cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.21835438.v1
title: Influence of anxiety and catastrophizing on pain perception in orthodontic treatment and its association with inflammatory cytokines

description: Abstract Pain is common in orthodontic treatment, is subject to individual variation, and is associated with anxiety and stress, which can potentially become catastrophizing. The aim of the present study was to determine the variability of pain response after the insertion of orthodontic separators and to assess the association of pain levels with dental anxiety, catastrophizing, tooth sensitivity, and genetic expression of cytokines. To this end, 70 patients of both genders were divided into two equal groups according to the elastomeric separator used: G1 (Dentaurum) and G2 (Orthometric). Two separators were inserted in the mesial and distal sides of the lower right first molar. Participants were instructed to rate the level of pain at T0 (before insertion), T1 (just after insertion), and T2 (24 hours after insertion) on a visual analog scale. The gingival crevicular fluid was collected at T0 and T2. The levels of anxiety, catastrophizing, tooth sensitivity, and cytokine expression were also assessed. Statistical analysis was performed with the Fisher-Freeman-Halton, chi-squared, Spearman’s correlation, and dependent and independent t tests (α=5%). Pain intensity was higher at T2 than at T1, in both groups (P&lt;.05). An association was established (P&lt;.05) between pain intensity at T1 and catastrophizing, and at T2 with anxiety and catastrophizing. Within-group differences in cytokine expression were found between T0 and T2. There was no correlation between cytokine expression and pain levels, anxiety, catastrophizing, and sensitivity at T2. Tooth separation produced variable pain levels, which were influenced by anxiety and catastrophizing, however, pain level was not correlated with increased cytokine expression.
DOI: 10.6084/m9.figshare.21835443
title: Antibiotic cement-coated plate is a viable and efficient technique for the definitive management of metaphyseal septic nonunions of the femur and tibia

description: ABSTRACT Objective: the management of septic metaphyseal nonunions is challenging, with inconsistent outcomes. Antibiotic cement-coated implants have been demonstrated good outcome for diaphyseal infected nonunions, however there is no data in metaphyseal infected nonunions. Methods: fifteen adult patients with septic metaphyseal nonunions of the femur or tibia were treated with antibiotic cement-coated plates. The antibiotic cement-coated plate was prepared with either gentamicin or vancomycin. Outcome measures were infection control, bone healing, return to pre-injury level on daily activities, and quality of life at the last follow-up visit. A p value of &lt;5% was considered significant. Results: Methicillin-susceptible S. aureus was isolated in 53.3% cases. Average postoperative follow-up time was 18 months. Local infection control and radiographic bone healing were adequately achieved in 93.3% patients. No patient presented recurrent symptoms of surgical site infection. Fourteen patients reported to be either able, or on the same level as before injury, with 73.3% reporting no problems in all five dimensions of the EQ-5D-3L. Persistent infection was the only variable associated with a reduced long-term quality of life. Conclusion: antibiotic cement-coated plate is a viable and efficient surgical technique for the definitive management of juxta-articular metaphyseal septic nonunions of the femur and tibia.
DOI: 10.6084/m9.figshare.21835443.v1
title: Antibiotic cement-coated plate is a viable and efficient technique for the definitive management of metaphyseal septic nonunions of the femur and tibia

description: ABSTRACT Objective: the management of septic metaphyseal nonunions is challenging, with inconsistent outcomes. Antibiotic cement-coated implants have been demonstrated good outcome for diaphyseal infected nonunions, however there is no data in metaphyseal infected nonunions. Methods: fifteen adult patients with septic metaphyseal nonunions of the femur or tibia were treated with antibiotic cement-coated plates. The antibiotic cement-coated plate was prepared with either gentamicin or vancomycin. Outcome measures were infection control, bone healing, return to pre-injury level on daily activities, and quality of life at the last follow-up visit. A p value of &lt;5% was considered significant. Results: Methicillin-susceptible S. aureus was isolated in 53.3% cases. Average postoperative follow-up time was 18 months. Local infection control and radiographic bone healing were adequately achieved in 93.3% patients. No patient presented recurrent symptoms of surgical site infection. Fourteen patients reported to be either able, or on the same level as before injury, with 73.3% reporting no problems in all five dimensions of the EQ-5D-3L. Persistent infection was the only variable associated with a reduced long-term quality of life. Conclusion: antibiotic cement-coated plate is a viable and efficient surgical technique for the definitive management of juxta-articular metaphyseal septic nonunions of the femur and tibia.
DOI: 10.6084/m9.figshare.21755638
title: Assessment of potentially toxic metals in water, sediment, and the tissues of seven important fish species from neotropical brazilian river

description: Abstract Fish are often used as bioindicators of the presence of potentially toxic metals in aquatic ecosystems. The objective of these study was to quantify the levels of Cd, Cr, Cu, Hg, Pb and Zn in water and sediment samples from the Sorocaba River and musculature and gill samples of seven species of fish (Hoplosternum littorale, Pterygoplichthys ambrosettii, Hypostomus ancistroides, Geophagus iporangensis, Prochilodus lineatus, Psalidodon cf. fasciatus, and Rhamdia quelen. In addition, the Bioaccumulation factor and Bioconcentration factor were obtained. The water and sediment analysis indicates average concentrations of metals below the maximum limit allowed by Brazilian legislation. Results above the legislation were found for chromium, in 18 samples: eight gills and 10 muscles. The trophic group that presented the highest contamination was the iliophages, followed by insectivores. There were no significant differences between the trophic groups in the absorption of the analyzed metals except for Zn and Hg in fish gills. The bioaccumulation factor in the gills and muscles showed that Hg and Zn had the highest values for the sediment in most species studied. Future research is needed to broaden the assessment as fish are consumed and water collection for supply has recently started downstream of the studied area.
DOI: 10.6084/m9.figshare.21755638.v1
title: Assessment of potentially toxic metals in water, sediment, and the tissues of seven important fish species from neotropical brazilian river

description: Abstract Fish are often used as bioindicators of the presence of potentially toxic metals in aquatic ecosystems. The objective of these study was to quantify the levels of Cd, Cr, Cu, Hg, Pb and Zn in water and sediment samples from the Sorocaba River and musculature and gill samples of seven species of fish (Hoplosternum littorale, Pterygoplichthys ambrosettii, Hypostomus ancistroides, Geophagus iporangensis, Prochilodus lineatus, Psalidodon cf. fasciatus, and Rhamdia quelen. In addition, the Bioaccumulation factor and Bioconcentration factor were obtained. The water and sediment analysis indicates average concentrations of metals below the maximum limit allowed by Brazilian legislation. Results above the legislation were found for chromium, in 18 samples: eight gills and 10 muscles. The trophic group that presented the highest contamination was the iliophages, followed by insectivores. There were no significant differences between the trophic groups in the absorption of the analyzed metals except for Zn and Hg in fish gills. The bioaccumulation factor in the gills and muscles showed that Hg and Zn had the highest values for the sediment in most species studied. Future research is needed to broaden the assessment as fish are consumed and water collection for supply has recently started downstream of the studied area.
DOI: 10.6084/m9.figshare.21835444
title: Relationship between the use and types of helmets with facial injuries - a prospective study

description: ABSTRACT Introduction: many studies have demonstrated the benefits of helmet to prevent and reduce severity of injuries in motorcyclists. Objective: the aim of the present study was to evaluate a possible relationship between the use of different types of helmets and the occurrence of facial injuries among victims of motorcycle accidents, seen at Hospital da Restauração, Recife/PE, Brazil. Materials and methods: demographic and trauma data were collected from hospitalized motorcycle accident victims with facial injuries from December 2020 to July 2021. Pearsons chi-square test was used to assess association between two categorical variables using a margin of error of 5%. Results: among the participants, the average age was 33.46 years. The age group between 18 and 29 years was the most prevalent. Most participants were male. 60.0% of motorcyclists used helmets at the time of the accident and of this percentage 37.6% used fixed full-face helmet, 16.5% open-face helmet and the other 5.9% articulated full-face helmet. 62.7% of participants had facial fractures. Among the fractures, those of the zygomatic-orbital complex were the most common fracture and were significantly associated with the use of helmets, especially with open-face helmet. Conclusions: the use of helmets was associated with a lower number of facial fractures among patients who were victims of motorcycle accidents. Fracture of the zygomatic-orbital complex was related to the absence of a helmet at the time of the accident, as well as the use of open-face helmets.
DOI: 10.6084/m9.figshare.21835444.v1
title: Relationship between the use and types of helmets with facial injuries - a prospective study

description: ABSTRACT Introduction: many studies have demonstrated the benefits of helmet to prevent and reduce severity of injuries in motorcyclists. Objective: the aim of the present study was to evaluate a possible relationship between the use of different types of helmets and the occurrence of facial injuries among victims of motorcycle accidents, seen at Hospital da Restauração, Recife/PE, Brazil. Materials and methods: demographic and trauma data were collected from hospitalized motorcycle accident victims with facial injuries from December 2020 to July 2021. Pearsons chi-square test was used to assess association between two categorical variables using a margin of error of 5%. Results: among the participants, the average age was 33.46 years. The age group between 18 and 29 years was the most prevalent. Most participants were male. 60.0% of motorcyclists used helmets at the time of the accident and of this percentage 37.6% used fixed full-face helmet, 16.5% open-face helmet and the other 5.9% articulated full-face helmet. 62.7% of participants had facial fractures. Among the fractures, those of the zygomatic-orbital complex were the most common fracture and were significantly associated with the use of helmets, especially with open-face helmet. Conclusions: the use of helmets was associated with a lower number of facial fractures among patients who were victims of motorcycle accidents. Fracture of the zygomatic-orbital complex was related to the absence of a helmet at the time of the accident, as well as the use of open-face helmets.
DOI: 10.6084/m9.figshare.9871211
title: The early training of Antônio Luis Cavalcanti de Albuquerque de Barros Barreto: an itinerary to the international health

description: Abstract The article analyzes the education and training of the physician Antônio Luis Cavalcanti de Albuquerque de Barros Barreto, who studied at both the Rio de Janeiro Faculty of Medicine and Oswaldo Cruz Institute and who promoted the Rockefeller Foundation’s project in Brazil. An examination of a will, oral accounts, Barros Barreto’s medical thesis, and newspaper reports reveals characteristics of the class of 1913 at the Oswaldo Cruz Institute Specialization Program and shows how these students engaged in the foundation’s international health initiatives. The text demonstrates how the idea of partnering with the foundation fueled controversies, impelled negotiations, and led to concessions in states where the foundation had yet to establish its presence, as in Pernambuco.
DOI: 10.6084/m9.figshare.9871211.v1
title: The early training of Antônio Luis Cavalcanti de Albuquerque de Barros Barreto: an itinerary to the international health

description: Abstract The article analyzes the education and training of the physician Antônio Luis Cavalcanti de Albuquerque de Barros Barreto, who studied at both the Rio de Janeiro Faculty of Medicine and Oswaldo Cruz Institute and who promoted the Rockefeller Foundation’s project in Brazil. An examination of a will, oral accounts, Barros Barreto’s medical thesis, and newspaper reports reveals characteristics of the class of 1913 at the Oswaldo Cruz Institute Specialization Program and shows how these students engaged in the foundation’s international health initiatives. The text demonstrates how the idea of partnering with the foundation fueled controversies, impelled negotiations, and led to concessions in states where the foundation had yet to establish its presence, as in Pernambuco.
DOI: 10.6084/m9.figshare.21835447
title: Evaluation of drug utilisation pattern and cost associated with diabetes mellitusType 2 management in Saudi Arabia

description: Abstract Diabetic mellitus is an emerging disease in Saudi Arabia. In this regard, a cross-sectional retrospective study was conducted to evaluate drug utilization pattern and the cost associated with non-insulin-dependent diabetes mellitus disease management in Saudi Arabia. Data retrieved from the electronic pharmacy records during the last one year were employed in this study. World Health Organization (WHO) Defined Daily Dose (DDD) method was employed to compute the daily price of each oral hypoglycaemic agent. The American Diabetes Association (ADA) guidelines and protocols were used to evaluate the level of adherence. A total of 17057 patients were enrolled in the study. Out of the 17057 patients enrolled in the study, 60.06 % (10246) were males and the rest females. In monotherapy, biguanides (metformin) were the most recommended and utilised drugs among 5673 patients (33.25%). The most commonly used drug combination was found to be sitagliptin+metformin (1754 units). The cost per unit dose was highest for liraglutide (A10BJ02) 258.32SR (68.79USD), and lowest for metformin (A10BA02) 0.49SR (0.13 USD). Metformin was the choice drug for the diabetes patients; biguanides (metformin) and DPP-4 (sitagliptins) were the most familiar established dose combination employed. Generic drugs should be used in order to reduce overall cost.
DOI: 10.6084/m9.figshare.21835447.v1
title: Evaluation of drug utilisation pattern and cost associated with diabetes mellitusType 2 management in Saudi Arabia

description: Abstract Diabetic mellitus is an emerging disease in Saudi Arabia. In this regard, a cross-sectional retrospective study was conducted to evaluate drug utilization pattern and the cost associated with non-insulin-dependent diabetes mellitus disease management in Saudi Arabia. Data retrieved from the electronic pharmacy records during the last one year were employed in this study. World Health Organization (WHO) Defined Daily Dose (DDD) method was employed to compute the daily price of each oral hypoglycaemic agent. The American Diabetes Association (ADA) guidelines and protocols were used to evaluate the level of adherence. A total of 17057 patients were enrolled in the study. Out of the 17057 patients enrolled in the study, 60.06 % (10246) were males and the rest females. In monotherapy, biguanides (metformin) were the most recommended and utilised drugs among 5673 patients (33.25%). The most commonly used drug combination was found to be sitagliptin+metformin (1754 units). The cost per unit dose was highest for liraglutide (A10BJ02) 258.32SR (68.79USD), and lowest for metformin (A10BA02) 0.49SR (0.13 USD). Metformin was the choice drug for the diabetes patients; biguanides (metformin) and DPP-4 (sitagliptins) were the most familiar established dose combination employed. Generic drugs should be used in order to reduce overall cost.
DOI: 10.6084/m9.figshare.21505783
title: Medical students’ perception about the self-management skills acquired during remote learning

description: Abstract: Introduction: The Covid-19 pandemic presented several challenges to Higher Education Institutions (HEIs) in all countries. In this context, there is a prominent need to restructure the teaching-learning process in order to guarantee genuine knowledge acquisition, as well as the development of study methods to enable students to deal with the emergency remote teaching (ERT) and its setbacks. Objective: To investigate directed study was implemented and how students viewed the gains in self-management skills during ERT. Method: Quantitative and qualitative cross-sectional study, conducted with 93 medical students from different Brazilian HEIs. A semi-structured questionnaire was used for data collection. The data were processed using the IRAMUTEQ software, similarity analysis and word cloud, in addition to the use of descriptive statistics. Results: In relation to the time dedicated to directed study, 59.1% of the students reported having established it and 57.0% said they had outlined strategies to better manage this time; 68.8% reported having perceived differences when comparing the learning consolidation methods used before and during ERT and, of these, 70.3% considered that these new techniques were efficient. In the qualitative analysis, six monothematic corpora were analysed, relating to opinions on what helped and what hindered emotional and time management, which learning consolidation strategies were used and which self-management skills were developed during ERT. Conclusion: It was demonstrated that the difficulties encountered were overcome through the adoption of strategies to help students develop self-management skills in relation to time, emotions and learning consolidation. It can therefore be inferred that students successfully mastered some of the essential skills to overcome new and recent challenges imposed by changes in the world, such as their personal organization, studies and time, in addition to those related to emotions and management of technological resources.
DOI: 10.6084/m9.figshare.21505783.v1
title: Medical students’ perception about the self-management skills acquired during remote learning

description: Abstract: Introduction: The Covid-19 pandemic presented several challenges to Higher Education Institutions (HEIs) in all countries. In this context, there is a prominent need to restructure the teaching-learning process in order to guarantee genuine knowledge acquisition, as well as the development of study methods to enable students to deal with the emergency remote teaching (ERT) and its setbacks. Objective: To investigate directed study was implemented and how students viewed the gains in self-management skills during ERT. Method: Quantitative and qualitative cross-sectional study, conducted with 93 medical students from different Brazilian HEIs. A semi-structured questionnaire was used for data collection. The data were processed using the IRAMUTEQ software, similarity analysis and word cloud, in addition to the use of descriptive statistics. Results: In relation to the time dedicated to directed study, 59.1% of the students reported having established it and 57.0% said they had outlined strategies to better manage this time; 68.8% reported having perceived differences when comparing the learning consolidation methods used before and during ERT and, of these, 70.3% considered that these new techniques were efficient. In the qualitative analysis, six monothematic corpora were analysed, relating to opinions on what helped and what hindered emotional and time management, which learning consolidation strategies were used and which self-management skills were developed during ERT. Conclusion: It was demonstrated that the difficulties encountered were overcome through the adoption of strategies to help students develop self-management skills in relation to time, emotions and learning consolidation. It can therefore be inferred that students successfully mastered some of the essential skills to overcome new and recent challenges imposed by changes in the world, such as their personal organization, studies and time, in addition to those related to emotions and management of technological resources.
DOI: 10.6084/m9.figshare.21744195
title: Circulation and Appropriation of Mineralogy Knowledge between America and Europe: Capitain Martín de Ocampo’s Arbitrations, 1605-1625

description: Abstract The objective of this article is to analyze the way mining knowledge circulated between America and Europe. The excise taxes elaborated by Captain Martín de Ocampo (Badajoz, ca. 1550 – Santafé de Bogotá, 1651) will be taken as an example to exploit and improve the performance of mercury, silver and gold mines located in Spain, in Peru. and in the New Kingdom of Granada. Ocampo was a mediator between local miners and Crown officials who knew how to take advantage of his experience as a conqueror and miner in different regions of the Catholic Monarchy to transfer empirical knowledge and serve as a connector for the mineralogical knowledge that circulated between the New and the Old Worlds. His professional life shows that knowledge did not always move in the Europe-America direction, but rather, on the contrary, from very early on the New World became a space where new mining techniques were developed, and others were improved, being used on both sides of the Atlantic Ocean.
DOI: 10.6084/m9.figshare.21744195.v1
title: Circulation and Appropriation of Mineralogy Knowledge between America and Europe: Capitain Martín de Ocampo’s Arbitrations, 1605-1625

description: Abstract The objective of this article is to analyze the way mining knowledge circulated between America and Europe. The excise taxes elaborated by Captain Martín de Ocampo (Badajoz, ca. 1550 – Santafé de Bogotá, 1651) will be taken as an example to exploit and improve the performance of mercury, silver and gold mines located in Spain, in Peru. and in the New Kingdom of Granada. Ocampo was a mediator between local miners and Crown officials who knew how to take advantage of his experience as a conqueror and miner in different regions of the Catholic Monarchy to transfer empirical knowledge and serve as a connector for the mineralogical knowledge that circulated between the New and the Old Worlds. His professional life shows that knowledge did not always move in the Europe-America direction, but rather, on the contrary, from very early on the New World became a space where new mining techniques were developed, and others were improved, being used on both sides of the Atlantic Ocean.