cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.5281/zenodo.5042633
title: Increasing production efficiency and coping with climate change, while ensuring sustainability and resilience

description: This experiment aims to test two of the most performing Tomres used as rootstocks in the commercial variety (Elpida F1) cultivated in the region. More specifically, 2 tomato Tomres lines (TOMRES- 149, Bil-6191 and TOMRES 162, M82) x 2 water/nutritional regimens (standard water/nutrient supply vs 20% irrigation reduction/no nutrient supply). Greenhouse will also have non grafted plants (Elpida F1) cultivated under standard water/nutrient supply and 20% irrigation reduction/no nutrient supply
DOI: 10.23729/132faa37-0917-4a7f-a0a9-9199be7a0f74
title: Data set for "Surface layer alteration of multi-oxide silicate glasses at a near-neutral pH in the presence of citric and tartaric acid"
title: Data for "Surface layer alteration of multi-oxide silicate glasses at a near-neutral pH in the presence of citric and tartaric acid"

description: XPS and XRF data for Surface layer alteration of multi-oxide silicate glasses at a near-neutral pH in the presence of citric and tartaric acid
description: Data for "Surface layer alteration of multi-oxide silicate glasses at a near-neutral pH in the presence of citric and tartaric acid"
DOI: 10.6084/m9.figshare.14883645
title: JVASP-5293.zip

description: JARVIS-DFT data test
DOI: 10.6084/m9.figshare.14883645.v1
title: JVASP-5293.zip

description: JARVIS-DFT data test
DOI: 10.6084/m9.figshare.14883651
title: JVASP-4213.zip

description: JARVIS-DFT data test
DOI: 10.6084/m9.figshare.14883651.v1
title: JVASP-4213.zip

description: JARVIS-DFT data test
DOI: 10.6084/m9.figshare.14883654.v1
title: JVASP-5296.zip

description: JARVIS-DFT data test
DOI: 10.6084/m9.figshare.14883654
title: JVASP-5296.zip

description: JARVIS-DFT data test
DOI: 10.5281/zenodo.5044080
title: Molecular Dynamics simulation data of Cyt c at pH 7 at the water|TFT interface

description: Programmed cell death via apoptosis is a natural defence against excessive cell division, crucial for foetal development to maintenance of homeostasis and elimination of precancerous and senescent cells. Here we demonstrate an electrified liquid bio-interface that replicates the molecular machinery of the inner mitochondrial membrane at the onset of apoptosis. By mimicking in vivo cytochrome c (Cyt c) interactions with cell membranes, our platform allows us to modulate the conformational plasticity of the protein by simply varying the electrochemical environment at an aqueous|organic interface. Remarkably, we observe interfacial electron transfer between an organic electron donor decamethylferrocene and O2, electrocatalysed by Cyt c. This interfacial reaction requires partial Cyt c unfolding, mimicking Cyt c in vivo peroxidase activity. As proof-of-concept, we use our electrified liquid bio-interface to identify drug molecules, such as bifonazole, that can potentially downregulate Cyt c and protect against uncontrolled neuronal cell death in neurodegenerative disorders.
DOI: 10.5281/zenodo.5044079
title: Molecular Dynamics simulation data of Cyt c at pH 7 at the water|TFT interface

description: Programmed cell death via apoptosis is a natural defence against excessive cell division, crucial for foetal development to maintenance of homeostasis and elimination of precancerous and senescent cells. Here we demonstrate an electrified liquid bio-interface that replicates the molecular machinery of the inner mitochondrial membrane at the onset of apoptosis. By mimicking in vivo cytochrome c (Cyt c) interactions with cell membranes, our platform allows us to modulate the conformational plasticity of the protein by simply varying the electrochemical environment at an aqueous|organic interface. Remarkably, we observe interfacial electron transfer between an organic electron donor decamethylferrocene and O2, electrocatalysed by Cyt c. This interfacial reaction requires partial Cyt c unfolding, mimicking Cyt c in vivo peroxidase activity. As proof-of-concept, we use our electrified liquid bio-interface to identify drug molecules, such as bifonazole, that can potentially downregulate Cyt c and protect against uncontrolled neuronal cell death in neurodegenerative disorders.
DOI: 10.6084/m9.figshare.14883666
title: Supplementary Material for: A Phase 2 Study of Camrelizumab for Advanced Hepatocellular Carcinoma: Two-Year Outcomes and Continued Treatment beyond First RECIST-Defined Progression

description: <b><i>Introduction:</i></b> In a multicenter, open-label, parallel-group, randomized, phase 2 study for pretreated advanced hepatocellular carcinoma (HCC), camrelizumab showed potent antitumor activity and acceptable safety profile. The aim of this report was to provide long-term data and evaluate potential benefit of treatment with camrelizumab beyond progression. <b><i>Methods:</i></b> From November 15, 2016, to November 16, 2017, 217 patients received camrelizumab 3 mg/kg intravenously every 2 or 3 weeks. Treatment beyond first Response Evaluation Criteria in Solid Tumors (RECIST)-defined progression (TBP) with camrelizumab was allowed. <b><i>Results:</i></b> At data cutoff of December 16, 2019 (&gt;2 years after the last patient enrollment; median duration of follow-up, 13.2 months [IQR 5.7–25.8]), 14 (43.8%) of the 32 responses per blinded independent central review were ongoing. The median duration of response was not reached (range 2.5–30.5 + months). The ongoing response rates at 12, 18, and 24 months were 68.3% (95% confidence interval [CI] 47.7–82.2), 59.8% (95% CI 38.8–75.6), and 53.1% (95% CI 31.0–71.0), respectively. The median overall survival (OS) was 14.2 months (95% CI 11.5–16.3). The 18- and 24-month OS rates were 41.3% (95% CI 34.6–47.9) and 33.7% (95% CI 27.3–40.2), respectively. Of the 172 patients who experienced RECIST-defined progression per investigator, 102 received TBP, while 70 did not (non-TBP). The median OS was 16.9 months (95% CI 13.3–22.6) in the TBP group versus 9.4 months (95% CI 5.8–14.8) in the non-TBP group, and the 18- and 24-month OS rates were 47.5% (95% CI 37.3–56.9) versus 33.1% (95% CI 22.3–44.3) and 38.8% (95% CI 29.2–48.4) versus 23.2% (95% CI 13.8–34.1), respectively. No new safety signals of camrelizumab were observed. <b><i>Conclusions:</i></b> With prolonged follow-up, camrelizumab continues to demonstrate the durable response and long survival in pretreated advanced HCC patients with manageable toxicities, especially in those who continued the treatment beyond first RECIST-defined progression.
DOI: 10.6084/m9.figshare.14883666.v1
title: Supplementary Material for: A Phase 2 Study of Camrelizumab for Advanced Hepatocellular Carcinoma: Two-Year Outcomes and Continued Treatment beyond First RECIST-Defined Progression

description: <b><i>Introduction:</i></b> In a multicenter, open-label, parallel-group, randomized, phase 2 study for pretreated advanced hepatocellular carcinoma (HCC), camrelizumab showed potent antitumor activity and acceptable safety profile. The aim of this report was to provide long-term data and evaluate potential benefit of treatment with camrelizumab beyond progression. <b><i>Methods:</i></b> From November 15, 2016, to November 16, 2017, 217 patients received camrelizumab 3 mg/kg intravenously every 2 or 3 weeks. Treatment beyond first Response Evaluation Criteria in Solid Tumors (RECIST)-defined progression (TBP) with camrelizumab was allowed. <b><i>Results:</i></b> At data cutoff of December 16, 2019 (&gt;2 years after the last patient enrollment; median duration of follow-up, 13.2 months [IQR 5.7–25.8]), 14 (43.8%) of the 32 responses per blinded independent central review were ongoing. The median duration of response was not reached (range 2.5–30.5 + months). The ongoing response rates at 12, 18, and 24 months were 68.3% (95% confidence interval [CI] 47.7–82.2), 59.8% (95% CI 38.8–75.6), and 53.1% (95% CI 31.0–71.0), respectively. The median overall survival (OS) was 14.2 months (95% CI 11.5–16.3). The 18- and 24-month OS rates were 41.3% (95% CI 34.6–47.9) and 33.7% (95% CI 27.3–40.2), respectively. Of the 172 patients who experienced RECIST-defined progression per investigator, 102 received TBP, while 70 did not (non-TBP). The median OS was 16.9 months (95% CI 13.3–22.6) in the TBP group versus 9.4 months (95% CI 5.8–14.8) in the non-TBP group, and the 18- and 24-month OS rates were 47.5% (95% CI 37.3–56.9) versus 33.1% (95% CI 22.3–44.3) and 38.8% (95% CI 29.2–48.4) versus 23.2% (95% CI 13.8–34.1), respectively. No new safety signals of camrelizumab were observed. <b><i>Conclusions:</i></b> With prolonged follow-up, camrelizumab continues to demonstrate the durable response and long survival in pretreated advanced HCC patients with manageable toxicities, especially in those who continued the treatment beyond first RECIST-defined progression.
DOI: 10.24396/ordar-77
title: 2016 - Phage analyses in the Orne River - Moselle watershed - France

description: Phage detection and quantification in river waters - flood monitoring of february 2016
DOI: 10.6084/m9.figshare.14883678
title: JVASP-5308.zip

description: JARVIS-DFT data test
DOI: 10.6084/m9.figshare.14883678.v1
title: JVASP-5308.zip

description: JARVIS-DFT data test
DOI: 10.6084/m9.figshare.14883681
title: JVASP-4400.zip

description: JARVIS-DFT data test
DOI: 10.6084/m9.figshare.14883681.v1
title: JVASP-4400.zip

description: JARVIS-DFT data test
DOI: 10.6084/m9.figshare.14883684
title: JVASP-350.zip

description: JARVIS-DFT data test
DOI: 10.6084/m9.figshare.14883684.v1
title: JVASP-350.zip

description: JARVIS-DFT data test
DOI: 10.6084/m9.figshare.14883687.v1
title: JVASP-542.zip

description: JARVIS-DFT data test
DOI: 10.6084/m9.figshare.14883687
title: JVASP-542.zip

description: JARVIS-DFT data test
DOI: 10.6084/m9.figshare.14883690.v1
title: JVASP-4403.zip

description: JARVIS-DFT data test
DOI: 10.5281/zenodo.5040741
title: Knowledge-intensive firms, connectivity and spatial restructuring: dynamics and differences in Germany and Switzerland

description: This dataset is based on the interlocking network model developed by the Globalization and World Cities Study Group (GaWC) at Loughborough University (Taylor 2004). It provides one specific way to address the question how inter‐city relations can be empirically measured despite the chronic lack of data on inter‐city information flows. The model uses a proxy – intra‐firm networks of multi‐branch, multi‐location enterprises – to estimate potential flows of knowledge‐creating information between cities and towns. The method was originally developed to measure the connectivity between global cities based on multi‐branch advanced producer services (APS) firms as they organize business activities across their offices worldwide. In this dataset, the model is adapted to measure relations between functional urban areas (FUAs) within and beyond the German and Swiss space economy, for both APS and High-Tech firms. In contrast to the original methodology, in this dataset the company locations were localized by the exact, georeferenced address, not only on the level of FUAs. The present dataset is created as part of the SNF research project “Knowledge-intensive firms, connectivity<br> and spatial restructuring: dynamics and differences in Germany and Switzerland”.
DOI: 10.6084/m9.figshare.14883690
title: JVASP-4403.zip

description: JARVIS-DFT data test
DOI: 10.17037/data.00002282
title: Data for: "Association between cervical dysplasia and female genital schistosomiasis diagnosed by genital PCR in Zambian women"

description: A tabular dataset that contains information used to investigate an association between cervical dysplasia and female genital schistosomiasis diagnosed by genital PCR in Zambian women, aged 18-31. Women were recruited from the Bilharzia and HIV (BILHIV) study in Zambia, which was a community-based study comparing genital self-sampling to provider obtained cervicovaginal-lavage for the diagnosis of FGS in women aged 18-31. FGS was defined as positive Schistosoma DNA from any genital PCR. Urogenital schistosomiasis diagnostics included urine circulating anodic antigen, urine microscopy and portable colposcopy. Participants were offered cervical cancer screening using VIA at a local hospital. Associations of PCR confirmed FGS and other diagnostics with VIA positivity were assessed using multivariable logistic regression.
DOI: 10.6084/m9.figshare.14883696
title: JVASP-302.zip

description: JARVIS-DFT data test
DOI: 10.6084/m9.figshare.14883696.v1
title: JVASP-302.zip

description: JARVIS-DFT data test
DOI: 10.5281/zenodo.5040850
title: Analysis of M82 tomato inoculated with Gigaspora margarita containing or not endobacteria under combined drought

description: In this experiment we tested if the tripartite interaction between tomato, AMF and endobacteria they host is able to improve plant resilience to water/nutrient stress. To this aim we used the Gigaspora margarita-CaGg (<em>Candidatus Glomeribacter gigasporarum</em>) biological system. Tomato M82 plants were inoculated with <em>G. margarita </em>spores containing its endobacterium (B+), cured spores without endobacterium (B-) or not inoculated (control) and grown under combined stress or not. Mycorrhizal colonization and plant traits were measured considering two time points, 60 days and 90 days after the experiment start. At the last sampling plant WUE/NUE and expression profiles of AM marker genes were measured. Results showed that <em>Gigaspora </em>is not a good symbiont for tomato since mycorrhizal frequency was rather low. Plant growth was not influenced by presence/absence of endobacteria while moderate water stress had the strongest impact. Interestingly we found that, irrespective of combined stress, B+ inoculated plants were more responsive to the AM symbiosis since they showed a higher activation of the 3 AM marker genes compared to the B- or not inoculated plants. These results indicate that the presence/absence of endobacteria could finely modulate plant metabolism at molecular level although a clear growth response was not detected.
description: DOI of Scientific publication: https://doi.org/10.3390/plants9070886
DOI: 10.5281/zenodo.5040849
title: Analysis of M82 tomato inoculated with Gigaspora margarita containing or not endobacteria under combined drought

description: In this experiment we tested if the tripartite interaction between tomato, AMF and endobacteria they host is able to improve plant resilience to water/nutrient stress. To this aim we used the Gigaspora margarita-CaGg (<em>Candidatus Glomeribacter gigasporarum</em>) biological system. Tomato M82 plants were inoculated with <em>G. margarita </em>spores containing its endobacterium (B+), cured spores without endobacterium (B-) or not inoculated (control) and grown under combined stress or not. Mycorrhizal colonization and plant traits were measured considering two time points, 60 days and 90 days after the experiment start. At the last sampling plant WUE/NUE and expression profiles of AM marker genes were measured. Results showed that <em>Gigaspora </em>is not a good symbiont for tomato since mycorrhizal frequency was rather low. Plant growth was not influenced by presence/absence of endobacteria while moderate water stress had the strongest impact. Interestingly we found that, irrespective of combined stress, B+ inoculated plants were more responsive to the AM symbiosis since they showed a higher activation of the 3 AM marker genes compared to the B- or not inoculated plants. These results indicate that the presence/absence of endobacteria could finely modulate plant metabolism at molecular level although a clear growth response was not detected.
description: DOI of Scientific publication: https://doi.org/10.3390/plants9070886
DOI: 10.6084/m9.figshare.14587608
title: Supplementary_Table_4_miRNA_DE_GLM_correlation_nutrient.xlsx

description: Supplementary Table 4. A) Stool miRNAs belonging to specific correlation clusters of nutrients or bacterial species as reported in Supplementary Figure 2B-C. B) List of miRNA-nutrient associations supported by a significant Spearman correlation (adj. p &lt; 0.05). Information of a GLM model computed for each pair is reported. Models adjusted by sex, age, and BMI.
DOI: 10.6084/m9.figshare.14587608.v1
title: Supplementary_Table_4_miRNA_DE_GLM_correlation_nutrient.xlsx

description: Supplementary Table 4. A) Stool miRNAs belonging to specific correlation clusters of nutrients or bacterial species as reported in Supplementary Figure 2B-C. B) List of miRNA-nutrient associations supported by a significant Spearman correlation (adj. p &lt; 0.05). Information of a GLM model computed for each pair are reported. Models adjusted by sex, age, and BMI.
DOI: 10.6084/m9.figshare.12587123.v1
title: Interviews

description: Interviews
DOI: 10.6084/m9.figshare.14883702
title: JVASP-4201.zip

description: JARVIS-DFT data test
DOI: 10.6084/m9.figshare.14883702.v1
title: JVASP-4201.zip

description: JARVIS-DFT data test
DOI: 10.5281/zenodo.5043202
title: A NOVEL AND INTEGRATED APPROACH TO INCREASE MULTIPLE AND COMBINED STRESS TOLERANCE IN PLANTS USING TOMATO AS A MODEL

description: This will be a screening experiment aiming a first evaluation of the five PGPR that have been isolated in AUA, Laboratory go General & Agricultural Microbiology in a previous research project. To minimize interference of the treatments with soil fertility and soil heterogeneity, this first experiment will be conducted in a soilless cultivation system
description: DOI of scientific publication: https://doi.org/10.3389/fpls.2021.670236
DOI: 10.5281/zenodo.5043201
title: A NOVEL AND INTEGRATED APPROACH TO INCREASE MULTIPLE AND COMBINED STRESS TOLERANCE IN PLANTS USING TOMATO AS A MODEL

description: This will be a screening experiment aiming a first evaluation of the five PGPR that have been isolated in AUA, Laboratory go General & Agricultural Microbiology in a previous research project. To minimize interference of the treatments with soil fertility and soil heterogeneity, this first experiment will be conducted in a soilless cultivation system
description: DOI of scientific publication: https://doi.org/10.3389/fpls.2021.670236
DOI: 10.5281/zenodo.5043735
title: Increasing production efficiency and coping with climate change, while ensuring sustainability and resilience

description: Isolation and screening of rhizobia to identify élite isolates that can maximize biological N2 fixation (BNF) in legumes used as intercrops or green manure under combined stress
description: DOI of scientific publication: https://doi.org/10.1016/j.syapm.2020.126149
DOI: 10.5281/zenodo.5043734
title: Increasing production efficiency and coping with climate change, while ensuring sustainability and resilience

description: Isolation and screening of rhizobia to identify élite isolates that can maximize biological N2 fixation (BNF) in legumes used as intercrops or green manure under combined stress
description: DOI of scientific publication: https://doi.org/10.1016/j.syapm.2020.126149
DOI: 10.6084/m9.figshare.14883579
title: DFT optimized geometries

description: XYZ coordinates of Metoclopramide (neutral and cation) and its intermediates and photoproducts.
DOI: 10.6084/m9.figshare.14883579.v1
title: DFT optimized geometries

description: XYZ coordinates of Metoclopramide (neutral and cation) and its intermediates and photoproducts.
DOI: 10.5281/zenodo.5042576
title: Increasing production efficiency and coping with climate change, while ensuring sustainability and resilience

description: The 3rd group of experiments (GE3) was designed to assess the effect of legume crops cultivated during autumn (from August to January) as cash crops or as green manure on the next tomato crop cultivated during spring (from February to July). Thus, GE3 included two experimental crops, one with legumes starting in August 2018 and terminated in January 2019 (GE3E1) and one with tomato, which started in February 2019 and terminated in July 2019 (GE3E2). In the experiment with legumes tested as preceding crops to tomato (GE3E1), four different treatments were established. In particular, treatment 1 (T1) was a cowpea crop cultivated as a cash crop aiming to produce cowpea pods during autumn 2018. Similarly, treatment 2 (T2) was a common bean crop cultivated as a cash crop aiming to produce commercially marketable common bean pods during autumn 2018. Treatment 3 (T3) was a faba bean crop aiming to be incorporated to the soil at anthesis as green manure. Finally, Treatment 4 (T4) was a faba bean crop aiming to be incorporated to the soil at anthesis as green manure
description: DOI of scientific publication: https://doi.org/10.3390/plants10030468
DOI: 10.5281/zenodo.5042575
title: Increasing production efficiency and coping with climate change, while ensuring sustainability and resilience

description: The 3rd group of experiments (GE3) was designed to assess the effect of legume crops cultivated during autumn (from August to January) as cash crops or as green manure on the next tomato crop cultivated during spring (from February to July). Thus, GE3 included two experimental crops, one with legumes starting in August 2018 and terminated in January 2019 (GE3E1) and one with tomato, which started in February 2019 and terminated in July 2019 (GE3E2). In the experiment with legumes tested as preceding crops to tomato (GE3E1), four different treatments were established. In particular, treatment 1 (T1) was a cowpea crop cultivated as a cash crop aiming to produce cowpea pods during autumn 2018. Similarly, treatment 2 (T2) was a common bean crop cultivated as a cash crop aiming to produce commercially marketable common bean pods during autumn 2018. Treatment 3 (T3) was a faba bean crop aiming to be incorporated to the soil at anthesis as green manure. Finally, Treatment 4 (T4) was a faba bean crop aiming to be incorporated to the soil at anthesis as green manure
description: DOI of scientific publication: https://doi.org/10.3390/plants10030468
DOI: 10.5281/zenodo.5045209
title: Increasing production efficiency and coping with climate change, while ensuring sustainability and resilience

description: Isolation and screening of rhizobia to identify élite isolates that can maximize biological N2 fixation (BNF) in legumes used as intercrops or green manure under combined stress
DOI: 10.5281/zenodo.5042443
title: Increasing production efficiency and coping with climate change, while ensuring sustainability and resilience

description: Isolation and screening of rhizobia to identify élite isolates that can maximize biological N2 fixation (BNF) in legumes used as intercrops or green manure under combined stress
DOI: 10.15161/oar.it/73886
title: CovidStat project data

description: This record contains the daily updated data of the CovidStat project. CovidStat is a project carried out by the CovidStat Working Group at INFN, whose creation was promoted within the Italian National Institute of Nuclear Physics with the aim of making a statistical analysis of the data provided daily by the Civil Protection on the spread of the pandemic in Italy. CovidStat data can interactively be browsed at https://covid19.infn.it.
description: The software to process this Root TTree is in the related identifier. Be sure to use the right corresponding version, based on the data in which Root TTree was generated.
DOI: 10.6084/m9.figshare.14883024
title: Source Data of "Tunable self-assembled Casimir microcavities and polaritons"

description: The source data for Figs 1- 4, including experimental and calculated optical spectra, SEM and optical images, and Mathematica codes for analysis, are provided as a Source Data file.
DOI: 10.6084/m9.figshare.14883024.v1
title: Source Data of "Tunable self-assembled Casimir microcavities and polaritons"

description: The source data for Figs 1- 4, including experimental and calculated optical spectra, and SEM and optical images, are provided as a Source Data file.
DOI: 10.24396/ordar-78
title: 2014 - Phage analyses in the waters of Orne River - Moselle watershed - France

description: Phage detection and quantification in the waters of the Orne river during the campaign of november 2014