DOI: 10.5255/ukda-sn-9254-1
title: National Child Development Study: Proteomics: Special Licence, 2002-2004
title: National Child Development Study, 1958 - Multi-omics Data and Risk Scores
title: NCDS

description: The &lt;span style="font-style: italic;"&gt;National Child Development Study&lt;/span&gt; (NCDS) is a continuing longitudinal study that seeks to follow the lives of all those living in Great Britain who were born in one particular week in 1958. The aim of the study is to improve understanding of the factors affecting human development over the whole lifespan. &lt;br&gt;&lt;br&gt;The NCDS has its origins in the &lt;span style="font-style: italic;"&gt;Perinatal Mortality Survey&lt;/span&gt; (PMS) (the original PMS study is held at the UK Data Archive under SN 2137). This study was sponsored by the National Birthday Trust Fund and designed to examine the social and obstetric factors associated with stillbirth and death in early infancy among the 17,000 children born in England, Scotland and Wales in that one week. Selected data from the PMS form NCDS sweep 0, held alongside NCDS sweeps 1-3, under SN 5565. &lt;br&gt;&lt;span style="font-style: italic;"&gt;&lt;br&gt;Survey and Biomeasures Data (GN 33004):&lt;/span&gt;&lt;br&gt;To date there have been nine attempts to trace all members of the birth cohort in order to monitor their physical, educational and social development. The first three sweeps were carried out by the National Children's Bureau, in 1965, when respondents were aged 7, in 1969, aged 11, and in 1974, aged 16 (these sweeps form NCDS1-3, held together with NCDS0 under SN 5565). The fourth sweep, also carried out by the National Children's Bureau, was conducted in 1981, when respondents were aged 23 (held under SN 5566). In 1985 the NCDS moved to the Social Statistics Research Unit (SSRU) - now known as the Centre for Longitudinal Studies (CLS). The fifth sweep was carried out in 1991, when respondents were aged 33 (held under SN 5567). For the sixth sweep, conducted in 1999-2000, when respondents were aged 42 (NCDS6, held under SN 5578), fieldwork was combined with the 1999-2000 wave of the &lt;span style="font-style: italic;"&gt;1970 Birth Cohort Study&lt;/span&gt; (BCS70), which was also conducted by CLS (and held under GN 33229). The seventh sweep was conducted in 2004-2005 when the respondents were aged 46 (held under SN 5579), the eighth sweep was conducted in 2008-2009 when respondents were aged 50 (held under SN 6137) and the ninth sweep was conducted in 2013 when respondents were aged 55 (held under SN 7669). &lt;br&gt;&lt;br&gt;Four separate datasets covering responses to NCDS over all sweeps are available. &lt;span style="font-style: italic;"&gt;National Child Development Deaths Dataset: Special Licence Access&lt;/span&gt; (SN 7717) covers deaths; &lt;span style="font-style: italic;"&gt;National Child Development Study Response and Outcomes Dataset&lt;/span&gt; (SN 5560) covers all other responses and outcomes; &lt;span style="font-style: italic;"&gt;National Child Development Study: Partnership Histories&lt;/span&gt; (SN 6940) includes data on live-in relationships; and &lt;span style="font-style: italic;"&gt;National Child Development Study: Activity Histories&lt;/span&gt; (SN 6942) covers work and non-work activities. Users are advised to order these studies alongside the other waves of NCDS.&lt;br&gt;&lt;br&gt;From 2002-2004, a Biomedical Survey was completed and is available under End User Licence (EUL) (SN 8731) and Special Licence (SL) (SN 5594). Proteomics analyses of blood samples are available under SL SN 9254.&lt;br&gt;&lt;br&gt;&lt;span style="font-style: italic;"&gt;Linked Geographical Data (GN 33497): &lt;br&gt;&lt;/span&gt;A number of geographical variables are available, under more restrictive access conditions, which can be linked to the NCDS EUL and SL access studies. &lt;br&gt;&lt;br&gt;&lt;span style="font-style: italic;"&gt;Linked Administrative Data (GN 33396):&lt;br&gt;&lt;/span&gt;A number of linked administrative datasets are available, under more restrictive access conditions, which can be linked to the NCDS EUL and SL access studies. These include a &lt;span style="font-style: italic;"&gt;Deaths&lt;/span&gt; dataset (SN 7717) available under SL and the &lt;span style="font-style: italic;"&gt;Linked Health Administrative Datasets&lt;/span&gt; (SN 8697) available under Secure Access.&lt;br&gt;&lt;br&gt;&lt;span style="font-style: italic;"&gt;Additional Sub-Studies (GN 33562):&lt;br&gt;&lt;/span&gt;In addition to the main NCDS sweeps, further studies have also been conducted on a range of subjects such as parent migration, unemployment, behavioural studies and respondent essays. The full list of NCDS studies available from the UK Data Service can be found on the &lt;a href="https://beta.ukdataservice.ac.uk/datacatalogue/series/series?id=2000032#!/access-data" target="_blank" style="background-color: rgb(255, 255, 255);"&gt;NCDS&lt;/a&gt; series access data webpage.  &lt;br&gt;&lt;br&gt;&lt;span style="font-style: italic;"&gt;How to access genetic and/or bio-medical sample data from a range of longitudinal surveys:&lt;br&gt;&lt;/span&gt;For information on how to access biomedical data from NCDS that are not held at the UKDS, see the &lt;a href="https://cls.ucl.ac.uk/data-access-training/genetic-data-and-biological-samples/" target="_blank" style="background-color: rgb(255, 255, 255);"&gt;CLS Genetic data and biological samples&lt;/a&gt; webpage.&lt;br&gt;&lt;br&gt;Further information about the full NCDS series can be found on the &lt;a href="https://cls.ucl.ac.uk/cls-studies/1958-national-child-development-study/" target="_blank" style="background-color: rgb(255, 255, 255);"&gt;Centre for Longitudinal Studies&lt;/a&gt; website.  &lt;p&gt;&lt;span style="font-style: italic;"&gt;National Child Development Study: Proteomics: Special Licence, 2002-2004&lt;/span&gt;&lt;br&gt;Proteomics analyses were run on the blood samples collected from NCDS participants in 2002-2004. This will substantially enhance NCDS and catalyse a step change in our understanding of the relationship between exposures from birth to midlife and their consequences for multiple physical and mental health disorders. It will provide high-dimensional biological information on these individuals during early midlife (aged 42 to 44), prior to the onset of most chronic disease, and at an age that is underrepresented in most cohorts, including UK Biobank (UKB).&lt;br&gt;&lt;br&gt;Embedding this technology within NCDS with linkage to existing genetics and biomarker data, repeat measures of social and biomedical exposures, and pre-clinical and clinical disease outcomes will drive a major uptake in NCDS data use, including by large-scale international academic consortia aiming to understand the determinants of healthy ageing.&lt;/p&gt;&lt;div&gt;&lt;br&gt;&lt;/div&gt;