cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.24925293
title: A modified recombinant adenovirus vector containing dual rabies virus G expression cassettes confers robust and long-lasting humoral immunity in mice, cats, and dogs

description: During the COVID-19 epidemic, the incidence of rabies has increased in several countries, especially in remote and disadvantaged areas, due to inadequate surveillance and declining immunization coverage. Multiple vaccinations with inactivated rabies virus vaccines for pre- or post-exposure prophylaxis are considered inefficient, expensive and impractical in developing countries. Herein, three modified human recombinant adenoviruses type 5 designated Adv-RVG, Adv-E1-RVG, and Adv-RVDG, carrying rabies virus G (RVG) expression cassettes in various combinations within <i>E1</i> or <i>E3</i> genomic regions, were constructed to serve as rabies vaccine candidates. Adv-RVDG mediated greater RVG expression both <i>in vitro</i> and <i>in vivo</i> and induced a more robust and durable humoral immune response than the rabies vaccine strain SAD-L16, Adv-RVG, and Adv-E1-RVG by more effectively activating the dendritic cells (DCs) – follicular helper T (Tfh) cells – germinal centre (GC) / memory B cells (MBCs) – long-lived plasma cells (LLPCs) axis with 100% survival after a lethal RABV challenge in mice during the 24-week study period. Similarly, dogs and cats immunized with Adv-RVDG showed stronger and longer-lasting antibody responses than those vaccinated with a commercial inactivated rabies vaccine and showed good tolerance to Adv-RVDG. In conclusion, our study demonstrated that simultaneous insertion of protective antigens into the <i>E1</i> and <i>E3</i> genomic regions of adenovirus vector can significantly enhance the immunogenicity of adenoviral-vectored vaccines, providing a theoretical and practical basis for the subsequent development of multivalent and multi-conjugated vaccines using recombinant adenovirus platform. Meanwhile, our data suggest Adv-RVDG is a safe, efficient, and economical vaccine for mass-coverage immunization.
DOI: 10.6084/m9.figshare.24925293.v2
title: A modified recombinant adenovirus vector containing dual rabies virus G expression cassettes confers robust and long-lasting humoral immunity in mice, cats, and dogs

description: During the COVID-19 epidemic, the incidence of rabies has increased in several countries, especially in remote and disadvantaged areas, due to inadequate surveillance and declining immunization coverage. Multiple vaccinations with inactivated rabies virus vaccines for pre- or post-exposure prophylaxis are considered inefficient, expensive and impractical in developing countries. Herein, three modified human recombinant adenoviruses type 5 designated Adv-RVG, Adv-E1-RVG, and Adv-RVDG, carrying rabies virus G (RVG) expression cassettes in various combinations within <i>E1</i> or <i>E3</i> genomic regions, were constructed to serve as rabies vaccine candidates. Adv-RVDG mediated greater RVG expression both <i>in vitro</i> and <i>in vivo</i> and induced a more robust and durable humoral immune response than the rabies vaccine strain SAD-L16, Adv-RVG, and Adv-E1-RVG by more effectively activating the dendritic cells (DCs) – follicular helper T (Tfh) cells – germinal centre (GC) / memory B cells (MBCs) – long-lived plasma cells (LLPCs) axis with 100% survival after a lethal RABV challenge in mice during the 24-week study period. Similarly, dogs and cats immunized with Adv-RVDG showed stronger and longer-lasting antibody responses than those vaccinated with a commercial inactivated rabies vaccine and showed good tolerance to Adv-RVDG. In conclusion, our study demonstrated that simultaneous insertion of protective antigens into the <i>E1</i> and <i>E3</i> genomic regions of adenovirus vector can significantly enhance the immunogenicity of adenoviral-vectored vaccines, providing a theoretical and practical basis for the subsequent development of multivalent and multi-conjugated vaccines using recombinant adenovirus platform. Meanwhile, our data suggest Adv-RVDG is a safe, efficient, and economical vaccine for mass-coverage immunization.
DOI: 10.6084/m9.figshare.26213334
title: A long-term stable cold-chain-friendly HIV mRNA vaccine encoding multi-epitope viral protease cleavage site immunogens inducing immunogen-specific protective T cell immunity

description: The lack of success in clinical trials for HIV vaccines highlights the need to explore novel strategies for vaccine development. Research on highly exposed seronegative (HESN) HIV-resistant Kenyan female sex workers revealed naturally protective immunity is correlated with a focused immune response mediated by virus-specific CD8 T cells. Further studies indicated that the immune response is unconventionally focused on highly conserved sequences around HIV viral protease cleavage sites (VPCS). Thus, taking an unconventional approach to HIV vaccine development, we designed lipid nanoparticles loaded with mRNA that encodes multi-epitopes of VPCS (MEVPCS-mRNA LNP), a strategic design to boost antigen presentation by dendritic cells, promoting effective cellular immunity. Furthermore, we developed a novel cold-chain compatible mRNA LNP formulation, ensuring long-term stability and compatibility with cold-chain storage/transport, widening accessibility of mRNA LNP vaccine in low-income countries. The <i>in-vivo</i> mouse study demonstrated that the vaccinated group generated VPCS-specific CD8 memory T cells, both systemically and at mucosal sites of viral entry. The MEVPCS-mRNA LNP vaccine-induced CD8 T cell immunity closely resembled that of the HESN group and displayed a polyfunctional profile. Notably, it induced minimal to no activation of CD4 T cells. This proof-of-concept study underscores the potential of the MEVPCS-mRNA LNP vaccine in eliciting CD8 T cell memory specific to the highly conserved multiple VPCS, consequently having a broad coverage in human populations and limiting viral escape mutation. The MEVPCS-mRNA LNP vaccine holds promise as a candidate for an effective prophylactic HIV vaccine.
DOI: 10.60712/si-id274467.1
title: StrainInfo SI-ID 274467.1

description: StrainInfo dataset 274467 about a strain of Zymoseptoria tritici. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data.
DOI: 10.60712/si-id274468.1
title: StrainInfo SI-ID 274468.1

description: StrainInfo dataset 274468 about a strain of Ganoderma lingzhi. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data.
DOI: 10.60712/si-id274469.1
title: StrainInfo SI-ID 274469.1

description: StrainInfo dataset 274469 about a strain of Teunomyces funiuensis. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data.
DOI: 10.60712/si-id274470.1
title: StrainInfo SI-ID 274470.1

description: StrainInfo dataset 274470 about a strain of Starmerella apicola. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data.
DOI: 10.60712/si-id274471.1
title: StrainInfo SI-ID 274471.1

description: StrainInfo dataset 274471 about a strain of Colletotrichum. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data.
DOI: 10.60712/si-id274472.1
title: StrainInfo SI-ID 274472.1

description: StrainInfo dataset 274472 about a strain of Hanseniaspora uvarum. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data.
DOI: 10.60712/si-id274473.1
title: StrainInfo SI-ID 274473.1

description: StrainInfo dataset 274473 about a strain of Pythium catenulatum. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data.
DOI: 10.60712/si-id274474.1
title: StrainInfo SI-ID 274474.1

description: StrainInfo dataset 274474 about a strain of Myxotrichum deflexum. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data.
DOI: 10.60712/si-id274475.1
title: StrainInfo SI-ID 274475.1

description: StrainInfo dataset 274475 about a strain of Grifola frondosa. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data.
DOI: 10.60712/si-id274476.1
title: StrainInfo SI-ID 274476.1

description: StrainInfo dataset 274476 about a strain of Helminthosporium solani. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data.
DOI: 10.60712/si-id274477.1
title: StrainInfo SI-ID 274477.1

description: StrainInfo dataset 274477 about a strain of Sphaeronaemella fimicola. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data.
DOI: 10.60712/si-id274478.1
title: StrainInfo SI-ID 274478.1

description: StrainInfo dataset 274478 about a strain of Ophiostoma boreale. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data.
DOI: 10.15468/dl.vub9n7
title: Occurrence Download

description: A dataset containing 33183 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Hyphantria cunea (Drury, 1773)"
 ]
}

 The dataset includes 33183 records from 129 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0004668-250227182400228/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.60712/si-id274479.1
title: StrainInfo SI-ID 274479.1

description: StrainInfo dataset 274479 about a strain of Fusarium avenaceum. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data.
DOI: 10.60712/si-id274480.1
title: StrainInfo SI-ID 274480.1

description: StrainInfo dataset 274480 about a strain of Pichia membranifaciens. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data.
DOI: 10.60712/si-id274481.1
title: StrainInfo SI-ID 274481.1

description: StrainInfo dataset 274481 about a strain of Leucogyrophana pinastri. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data.
DOI: 10.60712/si-id274482.1
title: StrainInfo SI-ID 274482.1

description: StrainInfo dataset 274482 about a strain of Hypoxylon hypomiltum. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data.
DOI: 10.60712/si-id274483.1
title: StrainInfo SI-ID 274483.1

description: StrainInfo dataset 274483 about a strain of Colletotrichum theobromicola. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data.
DOI: 10.60712/si-id274484.1
title: StrainInfo SI-ID 274484.1

description: StrainInfo dataset 274484 about a strain of Fomitiporia punctata. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data.
DOI: 10.60712/si-id274485.1
title: StrainInfo SI-ID 274485.1

description: StrainInfo dataset 274485 about a strain of Candida tropicalis. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data.
DOI: 10.60712/si-id274486.1
title: StrainInfo SI-ID 274486.1

description: StrainInfo dataset 274486 about a strain of Fomitiporia tsugina. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data.
DOI: 10.60712/si-id274487.1
title: StrainInfo SI-ID 274487.1

description: StrainInfo dataset 274487 about a strain of Pichia fermentans. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data.
DOI: 10.60712/si-id274488.1
title: StrainInfo SI-ID 274488.1

description: StrainInfo dataset 274488 about a strain of Aspergillus carbonarius. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data.
DOI: 10.60712/si-id274489.1
title: StrainInfo SI-ID 274489.1

description: StrainInfo dataset 274489 about a strain of a not identified species. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data.
DOI: 10.60712/si-id274490.1
title: StrainInfo SI-ID 274490.1

description: StrainInfo dataset 274490 about a strain of a not identified species. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data.
DOI: 10.60712/si-id274491.1
title: StrainInfo SI-ID 274491.1

description: StrainInfo dataset 274491 about a strain of Sungouiella intermedia. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data.
DOI: 10.60712/si-id274492.1
title: StrainInfo SI-ID 274492.1

description: StrainInfo dataset 274492 about a strain of Fomitiporia conyana. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data.
DOI: 10.60712/si-id274493.1
title: StrainInfo SI-ID 274493.1

description: StrainInfo dataset 274493 about a strain of Vishniacozyma victoriae. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data.
DOI: 10.60712/si-id274494.1
title: StrainInfo SI-ID 274494.1

description: StrainInfo dataset 274494 about a strain of Phellinus texanus. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data.
DOI: 10.60712/si-id274495.1
title: StrainInfo SI-ID 274495.1

description: StrainInfo dataset 274495 about a strain of Talaromyces heiheensis. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data.
DOI: 10.60712/si-id274496.1
title: StrainInfo SI-ID 274496.1

description: StrainInfo dataset 274496 about a strain of Haploporus eichelbaumii. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data.
DOI: 10.60712/si-id274497.1
title: StrainInfo SI-ID 274497.1

description: StrainInfo dataset 274497 about a strain of Fomitiporia gabonensis. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data.
DOI: 10.60712/si-id274498.1
title: StrainInfo SI-ID 274498.1

description: StrainInfo dataset 274498 about a strain of Xylaria. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data.
DOI: 10.60712/si-id274499.1
title: StrainInfo SI-ID 274499.1

description: StrainInfo dataset 274499 about a strain of Wickerhamiella domercqiae. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data.
DOI: 10.60712/si-id274500.1
title: StrainInfo SI-ID 274500.1

description: StrainInfo dataset 274500 about a strain of Zymoseptoria tritici. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data.
DOI: 10.60712/si-id274501.1
title: StrainInfo SI-ID 274501.1

description: StrainInfo dataset 274501 about a strain of Wickerhamiella azyma. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data.
DOI: 10.60712/si-id274502.1
title: StrainInfo SI-ID 274502.1

description: StrainInfo dataset 274502 about a strain of Sungouiella middelhoveniana. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data.
DOI: 10.60712/si-id274503.1
title: StrainInfo SI-ID 274503.1

description: StrainInfo dataset 274503 about a strain of Triadelphia uniseptata. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data.
DOI: 10.60712/si-id274504.1
title: StrainInfo SI-ID 274504.1

description: StrainInfo dataset 274504 about a strain of Fomitiporia calkinsii. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data.
DOI: 10.60712/si-id274505.1
title: StrainInfo SI-ID 274505.1

description: StrainInfo dataset 274505 about a strain of Cristataspora coffeata. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data.
DOI: 10.60712/si-id274506.1
title: StrainInfo SI-ID 274506.1

description: StrainInfo dataset 274506 about a strain of Saccharomyces pastorianus. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data.
DOI: 10.60712/si-id274507.1
title: StrainInfo SI-ID 274507.1

description: StrainInfo dataset 274507 about a strain of Yarrowia lipolytica. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data.
DOI: 10.60712/si-id274508.1
title: StrainInfo SI-ID 274508.1

description: StrainInfo dataset 274508 about a strain of Fuscoporia wahlbergii. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data.
DOI: 10.60712/si-id274509.1
title: StrainInfo SI-ID 274509.1

description: StrainInfo dataset 274509 about a strain of Haploporus grandisporus. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data.
DOI: 10.60712/si-id274510.1
title: StrainInfo SI-ID 274510.1

description: StrainInfo dataset 274510 about a strain of Neosartorya coreana. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data.
DOI: 10.60712/si-id274511.1
title: StrainInfo SI-ID 274511.1

description: StrainInfo dataset 274511 about a strain of Xylaria arbuscula. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data.
DOI: 10.60712/si-id274512.1
title: StrainInfo SI-ID 274512.1

description: StrainInfo dataset 274512 about a strain of Saccharomyces bayanus. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data.
DOI: 10.60712/si-id274513.1
title: StrainInfo SI-ID 274513.1

description: StrainInfo dataset 274513 about a strain of Phytophthora tropicalis. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data.
DOI: 10.60712/si-id274514.1
title: StrainInfo SI-ID 274514.1

description: StrainInfo dataset 274514 about a strain of Fibroporia vaillantii. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data.
DOI: 10.60712/si-id274515.1
title: StrainInfo SI-ID 274515.1

description: StrainInfo dataset 274515 about a strain of Scedosporium boydii. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data.
DOI: 10.60712/si-id274516.1
title: StrainInfo SI-ID 274516.1

description: StrainInfo dataset 274516 about a strain of Starmerella neotropicalis. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data.
DOI: 10.60712/si-id274517.1
title: StrainInfo SI-ID 274517.1

description: StrainInfo dataset 274517 about a strain of Aspergillus foetidus. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data.
DOI: 10.60712/si-id274518.1
title: StrainInfo SI-ID 274518.1

description: StrainInfo dataset 274518 about a strain of Solicoccozyma terricola. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data.
DOI: 10.7910/dvn/whpher
title: Replication Data for: Preventing School Dropout at Scale: Experimental Evidence from Guatemala

description: This is the replication package for "Preventing School Dropout at Scale: Experimental Evidence from Guatemala," accepted in 2025 by the Journal of Labor Economics.
DOI: 10.5281/zenodo.15238662
title: IODP Expedition 402 P-wave velocity caliper (section)

description: P-wave velocity data were measured on undisturbed section halves (JRSO-defined x-axis) and/or discrete cube and cylinder samples (x, y, or z-axis) using pairs of piezoelectric transducers mounted on a caliper system. Report includes P-wave velocity in x, y, and/or z-direction, caliper separation, traveltime between transucers, and first arrival picks.
DOI: 10.5281/zenodo.15238663
title: IODP Expedition 402 P-wave velocity caliper (section)

description: P-wave velocity data were measured on undisturbed section halves (JRSO-defined x-axis) and/or discrete cube and cylinder samples (x, y, or z-axis) using pairs of piezoelectric transducers mounted on a caliper system. Report includes P-wave velocity in x, y, and/or z-direction, caliper separation, traveltime between transucers, and first arrival picks.