cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.3120583
title: A record of post-collisional transition: evidence from geochronology and geochemistry of Palaeozoic volcanic rocks in the eastern Junggar, Central Asia

description: Abundant clues about the post-collisional transition in the southwestern margin of the Central Asian Orogenic Belt (CAOB) have been recorded by the late Palaeozoic volcanic rocks in the eastern Junggar region. These volcanic rocks provide a better window for understanding the magmatic and tectonic transition processes. This paper reports detailed petrology, whole-rock and Sr–Nd–Pb isotope geochemistry, and <i>in situ</i> zircon U–Pb dating analyses of these volcanic rocks from this region. Systematic geochemical and geochronological studies show that three stages of magmatism were recorded in this area, including ca. 407 Ma and ca. 340 Ma medium-to-high-K calc-alkaline series and ca. 320 Ma alkaline and tholeiite series. The ca. 407 Ma volcanic rocks have calc-alkaline compositions, strong enrichment in large-ion lithophile elements (LILEs) and depletion in high-field strength elements (HFSEs), negative Nb anomalies, and light REE (rare earth element)-enriched patterns. The ca. 340 Ma volcanic rocks, which have similar calc-alkaline compositions and arc geochemical affinities but higher K content, have slightly lower Th/Yb and Ba/Nb values than typical island arc or continental margin volcanic suites. The compositions of the ca. 320 Ma volcanic rocks display a bimodal distribution; the ca. 320 Ma basaltic rocks are chemically similar to oceanic island basalt (OIB) but with slight depletion in Nb and Ta, wheres the acidic rocks show the features of A-type granite. The chemical compositions of these volcanic rocks indicate that the ca. 407 Ma magmatism was subduction related, while the ca. 340 Ma and ca. 320 Ma volcanic rocks were the product of post-collisional magmatism. This transition from ca. 407 Ma to ca. 320 Ma records slab subduction, slab break-off, and slab rollback and provides a plausible explanation for the complex spatial and temporal geochemical evolution of magmatism in eastern Junggar since the Devonian.
DOI: 10.6084/m9.figshare.3120583.v1
title: A record of post-collisional transition: evidence from geochronology and geochemistry of Palaeozoic volcanic rocks in the eastern Junggar, Central Asia

description: Abundant clues about the post-collisional transition in the southwestern margin of the Central Asian Orogenic Belt (CAOB) have been recorded by the late Palaeozoic volcanic rocks in the eastern Junggar region. These volcanic rocks provide a better window for understanding the magmatic and tectonic transition processes. This paper reports detailed petrology, whole-rock and Sr–Nd–Pb isotope geochemistry, and <i>in situ</i> zircon U–Pb dating analyses of these volcanic rocks from this region. Systematic geochemical and geochronological studies show that three stages of magmatism were recorded in this area, including ca. 407 Ma and ca. 340 Ma medium-to-high-K calc-alkaline series and ca. 320 Ma alkaline and tholeiite series. The ca. 407 Ma volcanic rocks have calc-alkaline compositions, strong enrichment in large-ion lithophile elements (LILEs) and depletion in high-field strength elements (HFSEs), negative Nb anomalies, and light REE (rare earth element)-enriched patterns. The ca. 340 Ma volcanic rocks, which have similar calc-alkaline compositions and arc geochemical affinities but higher K content, have slightly lower Th/Yb and Ba/Nb values than typical island arc or continental margin volcanic suites. The compositions of the ca. 320 Ma volcanic rocks display a bimodal distribution; the ca. 320 Ma basaltic rocks are chemically similar to oceanic island basalt (OIB) but with slight depletion in Nb and Ta, wheres the acidic rocks show the features of A-type granite. The chemical compositions of these volcanic rocks indicate that the ca. 407 Ma magmatism was subduction related, while the ca. 340 Ma and ca. 320 Ma volcanic rocks were the product of post-collisional magmatism. This transition from ca. 407 Ma to ca. 320 Ma records slab subduction, slab break-off, and slab rollback and provides a plausible explanation for the complex spatial and temporal geochemical evolution of magmatism in eastern Junggar since the Devonian.
DOI: 10.6084/m9.figshare.3121840
title: Data from: Testing of Evaluation Bias for Progression Free Survival Endpoint in Oncology Clinical Trials

description: Progression free survival is an increasingly popular end point in oncology clinical trials. A complete blinded independent central review (BICR) is often required by regulators in an attempt to reduce the bias in PFS assessment. In this paper, we propose a new methodology that uses a sample-based BICR as an audit tool to decide whether a complete BICR is needed. More specifically, we propose a new index, the differential risk, to measure the reading discordance pattern, and develop a corresponding hypothesis testing procedure to decide whether the bias in local evaluation is acceptable. Simulation results demonstrate that our new index is sensitive to the change of discordance pattern; type I error is well controlled in the hypothesis testing procedure, and the calculated sample size provides the desired power.
DOI: 10.6084/m9.figshare.3121840.v1
title: Data from: Testing of Evaluation Bias for Progression Free Survival Endpoint in Oncology Clinical Trials

description: Progression free survival is an increasingly popular end point in oncology clinical trials. A complete blinded independent central review (BICR) is often required by regulators in an attempt to reduce the bias in PFS assessment. In this paper, we propose a new methodology that uses a sample-based BICR as an audit tool to decide whether a complete BICR is needed. More specifically, we propose a new index, the differential risk, to measure the reading discordance pattern, and develop a corresponding hypothesis testing procedure to decide whether the bias in local evaluation is acceptable. Simulation results demonstrate that our new index is sensitive to the change of discordance pattern; type I error is well controlled in the hypothesis testing procedure, and the calculated sample size provides the desired power.
DOI: 10.6084/m9.figshare.4154241
title: Content-based Discovery for Web Map Service using Support Vector Machine and User Relevance Feedback (Supporting Dataset)

description: This dataset provides the supporting files for the paper entitled "Content-based Discovery for Web Map Service using Support Vector Machine and User Relevance Feedback", which has been accepted by PLOS ONE. The DOI of the paper is 10.1371/journal.pone.0166098. <br>The dataset includes11689 layers from 653 OGC WMSs. It contains a archive of 11689 thumbnail images, two WMS layer metadata description files (in SQL script and CSV format respectively), an extracted image feature files and a data introduction document. Specially, the thumbnails are obtained by invoking WMS GetMap Operation for the available layers. The two layer metadata description files depict attribute fields of the layers, including keywords, abstract, boundingbox and etc. The image features were extracted from the WMS layer thumbnail images and contains total 11689 records. If you are interested in this research, please contact with hukai@whu.edu.cn or  zhipeng.gui@whu.edu.cn.
DOI: 10.6084/m9.figshare.4154241.v1
title: 11689Layers_ImageFeatureVector_115Elements.csv

description: These features are extracted from the WMS layer thumbnail images and contains total 11689 records.
DOI: 10.6084/m9.figshare.4154241.v4
title: Content-based Discovery for Web Map Service using Support Vector Machine and User Relevance Feedback (Supporting Dataset)

description: This dataset provides the supporting files for the paper entitled "Content-based Discovery for Web Map Service using Support Vector Machine and User Relevance Feedback", which has been accepted by PLOS ONE. The DOI of the paper is 10.1371/journal.pone.0166098. <br>The dataset includes11689 layers from 653 OGC WMSs. It contains a archive of 11689 thumbnail images, two WMS layer metadata description files (in SQL script and CSV format respectively), an extracted image feature files and a data introduction document. Specially, the thumbnails are obtained by invoking WMS GetMap Operation for the available layers. The two layer metadata description files depict attribute fields of the layers, including keywords, abstract, boundingbox and etc. The image features were extracted from the WMS layer thumbnail images and contains total 11689 records. If you are interested in this research, please contact with hukai@whu.edu.cn or  zhipeng.gui@whu.edu.cn.
DOI: 10.6084/m9.figshare.4154241.v3
title: Content-based Discovery for Web Map Service using Support Vector Machine and User Relevance Feedback_Support_data

description: The support files contains the 11689 thumbnail images, the WMSlayer SQL script and CSV format file, the extracted image features and the data introductions. Specially, the thumbnails are obtained by making thumbnails of the WMS layers whose details can be found in the WMSlayer SQL or CSV files. These features are extracted from the WMS layer thumbnail images and contains total 11689 records. The paper will be accepted in the Journal of PLOS ONE. The doi of the paper is 10.1371/journal.pone.0166098. The paper's title is Content-based Discovery for Web Map Service using Support Vector Machine and User Relevance Feedback. If you are interested in the paper content and want to have further discussion with us, please contact hukai@whu.edu.cn or  zhipeng.gui@whu.edu.cn.
DOI: 10.6084/m9.figshare.4168227
title: Supplemental Table 1 Length distribution of unigenes from C. oleifera.xls

description: Length distribution of
unigenes, CDS through blast and ESTscan respectively from <i>C. oleifera</i>
DOI: 10.6084/m9.figshare.4168227.v1
title: Supplemental Table 1 Length distribution of unigenes from C. oleifera.xls

description: Length distribution of
unigenes, CDS through blast and ESTscan respectively from <i>C. oleifera</i>
DOI: 10.6084/m9.figshare.4168233
title: Supplemental Table 2 KEGG annotation of unigenes.xlsx

description: KEGG annotation of the
unigenes
DOI: 10.6084/m9.figshare.4168239
title: Supplemental Table 3.xls

description: The statistical table of the unigenes of five major clusters (A-E) with significant
enrichment trend. A. The down-regulated
unigenes under drought stress in cluster A, unigenes descriptions, changes in
expression, KEGG metabolic pathways and GO terms annotation.B. The
down-regulated unigenes under drought stress in cluster B, unigenes
descriptions, changes in expression, KEGG metabolic pathways and GO terms
annotation. C. The down-regulated unigenes under drought stress in cluster C,
unigenes descriptions, changes in expression, KEGG metabolic pathways and GO
terms annotation. D. The up-regulated unigenes under drought stress in cluster
D, unigenes descriptions, changes in expression, KEGG metabolic pathways and GO
terms annotation. E. The up-regulated unigenes under drought stress in cluster
E, unigenes descriptions, changes in expression, KEGG metabolic pathways and GO
terms annotation.
DOI: 10.6084/m9.figshare.4168239.v1
title: Supplemental Table 3.xls

description: The statistical table of the unigenes of five major clusters (A-E) with significant
enrichment trend. A. The down-regulated
unigenes under drought stress in cluster A, unigenes descriptions, changes in
expression, KEGG metabolic pathways and GO terms annotation.B. The
down-regulated unigenes under drought stress in cluster B, unigenes
descriptions, changes in expression, KEGG metabolic pathways and GO terms
annotation. C. The down-regulated unigenes under drought stress in cluster C,
unigenes descriptions, changes in expression, KEGG metabolic pathways and GO
terms annotation. D. The up-regulated unigenes under drought stress in cluster
D, unigenes descriptions, changes in expression, KEGG metabolic pathways and GO
terms annotation. E. The up-regulated unigenes under drought stress in cluster
E, unigenes descriptions, changes in expression, KEGG metabolic pathways and GO
terms annotation.
DOI: 10.6084/m9.figshare.4168242
title: Supplemental Table 4.xlsx

description: The detailed lists with all
unigenes of important KEGG metabolic pathways of <i>C. oleifera</i> under drought stress. A. The
unigenes related to the circadian rhythm-plant pathway. B. The unigenes
related to the flavone and flavonol biosynthesis pathway. C. The unigenes
related to the ribosome pathway
DOI: 10.6084/m9.figshare.4168242.v1
title: Supplemental Table 4.xlsx

description: The detailed lists with all
unigenes of important KEGG metabolic pathways of <i>C. oleifera</i> under drought stress. A. The
unigenes related to the circadian rhythm-plant pathway. B. The unigenes
related to the flavone and flavonol biosynthesis pathway. C. The unigenes
related to the ribosome pathway
DOI: 10.6084/m9.figshare.4176558
title: CANCERTOPE_MUTATION_DATASET.txt

description: The dataset of Cancertope containing the sequence variants containing mutations in the original sequences.
DOI: 10.6084/m9.figshare.4176558.v1
title: CANCERTOPE_MUTATION_DATASET.txt

description: The dataset of Cancertope containing the sequence variants containing mutations in the original sequences.
DOI: 10.5281/zenodo.10866013
title: curcuma_caesia_zanfona_1.fasta.gz

description: .
DOI: 10.5281/zenodo.10866014
title: curcuma_caesia_zanfona_1.fasta.gz

description: .
DOI: 10.6084/m9.figshare.4203141
title: Global epidemiology of diabetic foot ulceration: a systematic review and meta-analysis<sup>†</sup>

description: Diabetic foot is a severe public health issue, yet rare studies investigated its global epidemiology. Here we performed a systematic review and meta-analysis through searching PubMed, EMBASE, ISI Web of science, and Cochrane database. We found that that global diabetic foot ulcer prevalence was 6.3% (95%CI: 5.4–7.3%), which was higher in males (4.5%, 95%CI: 3.7–5.2%) than in females (3.5%, 95%CI: 2.8–4.2%), and higher in type 2 diabetic patients (6.4%, 95%CI: 4.6–8.1%) than in type 1 diabetics (5.5%, 95%CI: 3.2–7.7%). North America had the highest prevalence (13.0%, 95%CI: 10.0–15.9%), Oceania had the lowest (3.0%, 95% CI: 0.9–5.0%), and the prevalence in Asia, Europe, and Africa were 5.5% (95%CI: 4.6–6.4%), 5.1% (95%CI: 4.1–6.0%), and 7.2% (95%CI: 5.1–9.3%), respectively. Australia has the lowest (1.5%, 95%CI: 0.7–2.4%) and Belgium has the highest prevalence (16.6%, 95%CI: 10.7–22.4%), followed by Canada (14.8%, 95%CI: 9.4–20.1%) and USA (13.0%, 95%CI: 8.3–17.7%). The patients with diabetic foot ulcer were older, had a lower body mass index, longer diabetic duration, and had more hypertension, diabetic retinopathy, and smoking history than patients without diabetic foot ulceration. Our results provide suggestions for policy makers in deciding preventing strategy of diabetic foot ulceration in the future.Key messagesGlobal prevalence of diabetic foot is 6.3% (95%CI: 5.4–7.3%), and the prevalence in North America, Asia, Europe, Africa and Oceania was 13.0% (95%CI: 10.0–15.9%), 5.5% (95%CI: 4.6–6.4%), 5.1% (95%CI: 4.1–6.0%), 7.2% (95%CI: 5.1–9.3%), and 3.0% (95% CI: 0.9–5.0%).Diabetic foot was more prevalent in males than in females, and more prevalent in type 2 diabetic foot patients than in type 1 diabetic foot patients.The patients with diabetic foot were older, had a lower body mass index, longer diabetic duration, and had more hypertension, diabetic retinopathy, and smoking history than patients without diabetic foot. Global prevalence of diabetic foot is 6.3% (95%CI: 5.4–7.3%), and the prevalence in North America, Asia, Europe, Africa and Oceania was 13.0% (95%CI: 10.0–15.9%), 5.5% (95%CI: 4.6–6.4%), 5.1% (95%CI: 4.1–6.0%), 7.2% (95%CI: 5.1–9.3%), and 3.0% (95% CI: 0.9–5.0%). Diabetic foot was more prevalent in males than in females, and more prevalent in type 2 diabetic foot patients than in type 1 diabetic foot patients. The patients with diabetic foot were older, had a lower body mass index, longer diabetic duration, and had more hypertension, diabetic retinopathy, and smoking history than patients without diabetic foot.
DOI: 10.6084/m9.figshare.4203141.v1
title: Global epidemiology of diabetic foot ulceration: a systematic review and meta-analysis<sup>†</sup>

description: Diabetic foot is a severe public health issue, yet rare studies investigated its global epidemiology. Here we performed a systematic review and meta-analysis through searching PubMed, EMBASE, ISI Web of science, and Cochrane database. We found that that global diabetic foot ulcer prevalence was 6.3% (95%CI: 5.4–7.3%), which was higher in males (4.5%, 95%CI: 3.7–5.2%) than in females (3.5%, 95%CI: 2.8–4.2%), and higher in type 2 diabetic patients (6.4%, 95%CI: 4.6–8.1%) than in type 1 diabetics (5.5%, 95%CI: 3.2–7.7%). North America had the highest prevalence (13.0%, 95%CI: 10.0–15.9%), Oceania had the lowest (3.0%, 95% CI: 0.9–5.0%), and the prevalence in Asia, Europe, and Africa were 5.5% (95%CI: 4.6–6.4%), 5.1% (95%CI: 4.1–6.0%), and 7.2% (95%CI: 5.1–9.3%), respectively. Australia has the lowest (1.5%, 95%CI: 0.7–2.4%) and Belgium has the highest prevalence (16.6%, 95%CI: 10.7–22.4%), followed by Canada (14.8%, 95%CI: 9.4–20.1%) and USA (13.0%, 95%CI: 8.3–17.7%). The patients with diabetic foot ulcer were older, had a lower body mass index, longer diabetic duration, and had more hypertension, diabetic retinopathy, and smoking history than patients without diabetic foot ulceration. Our results provide suggestions for policy makers in deciding preventing strategy of diabetic foot ulceration in the future.Key messagesGlobal prevalence of diabetic foot is 6.3% (95%CI: 5.4–7.3%), and the prevalence in North America, Asia, Europe, Africa and Oceania was 13.0% (95%CI: 10.0–15.9%), 5.5% (95%CI: 4.6–6.4%), 5.1% (95%CI: 4.1–6.0%), 7.2% (95%CI: 5.1–9.3%), and 3.0% (95% CI: 0.9–5.0%).Diabetic foot was more prevalent in males than in females, and more prevalent in type 2 diabetic foot patients than in type 1 diabetic foot patients.The patients with diabetic foot were older, had a lower body mass index, longer diabetic duration, and had more hypertension, diabetic retinopathy, and smoking history than patients without diabetic foot. Global prevalence of diabetic foot is 6.3% (95%CI: 5.4–7.3%), and the prevalence in North America, Asia, Europe, Africa and Oceania was 13.0% (95%CI: 10.0–15.9%), 5.5% (95%CI: 4.6–6.4%), 5.1% (95%CI: 4.1–6.0%), 7.2% (95%CI: 5.1–9.3%), and 3.0% (95% CI: 0.9–5.0%). Diabetic foot was more prevalent in males than in females, and more prevalent in type 2 diabetic foot patients than in type 1 diabetic foot patients. The patients with diabetic foot were older, had a lower body mass index, longer diabetic duration, and had more hypertension, diabetic retinopathy, and smoking history than patients without diabetic foot.
DOI: 10.6084/m9.figshare.4203147
title: Endothelin-receptor antagonist can reduce blood pressure in patients with hypertension: a meta-analysis

description: The aim of this meta-analysis was to assess the effectiveness and safety of endothelin-receptor antagonist (ERA) in the patients with hypertension. Searches of the PubMed, EMBASE, and CENTRAL databases were conducted to include all the randomized control trials (RCTs). Eighteen trials including 4898 patients were used in the meta-analysis, of which nine were classified as low risk of bias and the other nine as unclear risk of bias. There was no statistically significant difference in all-cause mortality between ERA and placebo groups [6 trials, fixed effects model, RR 1.53 (0.89–2.62); random effects model, RR 1.45 (0.84–2.52)]. ERA significantly reduced 24-h ambulatory blood pressure and sitting blood pressure in patients with hypertension [5 trials, 24-h SBP: WMD −7.65 (−8.95 to −6.36), 24-h DBP: WMD −5.92 (−7.50 to −4.33); 18 trials, SBP: WMD −6.12 (−7.87 to −4.36), DBP: WMD −3.81 (−4.82 to −2.80)]. However, ERA had more adverse events [within 24 h: 3 trials, RR 1.16 (0.82–1.65); after 24 h, 13 trials, RR 1.21 (1.08–1.36)] and severe adverse events than placebo controls [SAE: 9 trials, RR 1.34 (1.13–1.60)]. In addition, there is a potential need for further RCTs that focus on the use of ERA in patients with hypertension.
DOI: 10.6084/m9.figshare.4203147.v1
title: Endothelin-receptor antagonist can reduce blood pressure in patients with hypertension: a meta-analysis

description: The aim of this meta-analysis was to assess the effectiveness and safety of endothelin-receptor antagonist (ERA) in the patients with hypertension. Searches of the PubMed, EMBASE, and CENTRAL databases were conducted to include all the randomized control trials (RCTs). Eighteen trials including 4898 patients were used in the meta-analysis, of which nine were classified as low risk of bias and the other nine as unclear risk of bias. There was no statistically significant difference in all-cause mortality between ERA and placebo groups [6 trials, fixed effects model, RR 1.53 (0.89–2.62); random effects model, RR 1.45 (0.84–2.52)]. ERA significantly reduced 24-h ambulatory blood pressure and sitting blood pressure in patients with hypertension [5 trials, 24-h SBP: WMD −7.65 (−8.95 to −6.36), 24-h DBP: WMD −5.92 (−7.50 to −4.33); 18 trials, SBP: WMD −6.12 (−7.87 to −4.36), DBP: WMD −3.81 (−4.82 to −2.80)]. However, ERA had more adverse events [within 24 h: 3 trials, RR 1.16 (0.82–1.65); after 24 h, 13 trials, RR 1.21 (1.08–1.36)] and severe adverse events than placebo controls [SAE: 9 trials, RR 1.34 (1.13–1.60)]. In addition, there is a potential need for further RCTs that focus on the use of ERA in patients with hypertension.
DOI: 10.6084/m9.figshare.4204719
title: Structure-based QSAR, molecule design and bioassays of protease-activated receptor 1 inhibitors

description: Quantitative structure–activity relationship (QSAR) studies were performed on a series of protease-activated receptor 1 (PAR1) inhibitors to identify the key structural features responsible for their biological activity. Induced-fit docking (IFD) was used to explore the active mechanisms of all PAR1 inhibitors at the active pocket of PAR1, and the best plausible conformation was determined by IFD for further QSAR studies. Based on the best plausible conformation, structure-based descriptors and ligand descriptors incorporating the ligand–receptor interaction were calculated. The random forest method was used to select important descriptors and build the 2D-QSAR model. The results of the 2D-QSAR model gave a squared correlation coefficient (<i>R</i><sup>2</sup>) of 0.937, a prediction squared correlation coefficient (<i>R</i><sup>2</sup><sub>pred</sub>) of 0.845 and a mean square error (MSE) of 0.056. Furthermore, a 3D-QSAR model was developed via topomer comparative molecular field analysis (Topomer CoMFA), resulting in an <i>R</i><sup>2</sup> of 0.938, a cross-validated <i>Q</i><sup>2</sup> of 0.503 and a <i>R</i><sup>2</sup><sub>pred</sub> of 0.758. Based on the developed QSAR model, Topomer search was used for virtual screening of the R2 fragment in lead-like inhibitors from the National Cancer Institute (NCI) database, which contains 260,000 molecules. Eighty-two compounds were designed with different R2 fragments, and four of these compounds were selected for further biological testing. All four compounds showed inhibitory potency against PAR1.