cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.6530771
title: Supplementary Material for: Multidisciplinary Late Effects Clinics for Childhood Cancer Survivors in Germany - a Two-Center Study

description: Background: Childhood cancer survivors are at risk for therapy-related sequelae and, therefore, require longterm follow-up. At 2 university hospitals in Germany collaborative multidisciplinary late effects clinics were installed to provide specialized care and to evaluate the current health status of these patients in a clinical setting. Patients and Methods: Every patient who visited the late effects clinics at the university hospital in Lübeck and Erlangen over a period of 3 years and met the inclusion criteria was included in the study. Patients’ characteristics as well as cancer diagnosis, treatment related factors and the prevalence of chronic health conditions were assessed. Results: 220 patients attended the late effects clinics during the observation period. The median follow-up period was 16 years (range 5–45 years). In total over 64% of the patients were affected by at least 1 chronic health condition, including endocrine disruptions in 19.1% of the patients. Moreover, secondary neoplasms occurred in 9.1% of the study participants. Conclusion: German childhood cancer survivors are affected by multiple therapy-related sequelae. A comprehensive network of late effects clinics should be established to ensure specialized and risk-adapted care for every childhood cancer survivor in Germany.
DOI: 10.6084/m9.figshare.6530765
title: Supplementary Material for: Overall Survival Benefit from Trastuzumab-Based Treatment in HER2-Positive Metastatic Breast Cancer: A Retrospective Analysis

description: Aim: The purposes of our study were to compare the clinical outcomes of human epidermal growth factor receptor 2 (HER2)-positive metastatic breast cancer (mBC) patients with or without trastuzumab treatment and HER2-negative patients, and to explore factors that might predict the survival benefit associated with trastuzumab treatment in HER2-positive breast cancer. Patients and Methods: A total of 421 patients with mBC were analyzed in this retrospective study. All patients had first-line chemotherapy with or without trastuzumab. They were classified into 3 groups according to their HER2 status and trastuzumab treatment: HER2positive mBC patients with or without trastuzumab treatment and HER2-negative patents. Results: Trastuzumab administration in HER2-positive mBC patients significantly prolonged overall survival (33 vs. 26 months; P = 0.003) and led to a 49.8% reduction in death risk. In the subgroup analysis, HER2-positive patients with hormone receptor (HR)-negative status (29 vs. 17 months; P = 0.000) or visceral metastasis (30 vs. 21 months; P = 0.000) had more survival benefit when treated with trastuzumab. Conclusions: Trastuzumab administration significantly improved the overall survival in HER2-positive mBC patients, who gained a prognosis comparable to that of patients with HER2-negative disease. HR status and metastasis site might be important surrogate makers that predict survival benefit from trastuzumab-based treatment.
DOI: 10.6084/m9.figshare.6530756
title: Supplementary Table S2. The Toarcian Oceanic Anoxic Event in southwestern Gondwana: An example from the Andean Basin, northern Chile

description: Supplementary Table S2: The coefficient of correlation (<i>r</i>) for major and trace elements.
DOI: 10.6084/m9.figshare.6530756.v1
title: Supplementary Table S2. The Toarcian Oceanic Anoxic Event in southwestern Gondwana: An example from the Andean Basin, northern Chile

description: Supplementary Table S2: The coefficient of correlation (<i>r</i>) for major and trace elements.
DOI: 10.6084/m9.figshare.6530753
title: Supplementary Table S1. The Toarcian Oceanic Anoxic Event in southwestern Gondwana: An example from the Andean Basin, northern Chile

description: Supplementary Table S1: Geochemical and mineralogical data for Asientos and El Peñon
DOI: 10.6084/m9.figshare.6530753.v1
title: Supplementary Table S1. The Toarcian Oceanic Anoxic Event in southwestern Gondwana: An example from the Andean Basin, northern Chile

description: Supplementary Table S1: Geochemical and mineralogical data for Asientos and El Peñon
DOI: 10.6084/m9.figshare.6530642
title: Dataset for Crystal Structure Prediction

description: This dataset has initial structures and results of local optimization steps for crystalline systems Si, NaCl, Y2Co17, Al2O3, and GaAs.
DOI: 10.6084/m9.figshare.6530642.v1
title: Dataset for Crystal Structure Prediction

description: This dataset has initial structures and results of local optimization steps for crystalline systems Si, NaCl, Y2Co17, Al2O3, and GaAs.
DOI: 10.6084/m9.figshare.6530606
title: Bootstrap entropy test for general location-scale time series models with heteroscedasticity

description: This study considers a goodness-of-fit test for location-scale time series models with heteroscedasticity, including a broad class of generalized autoregressive conditional heteroscedastic-type models. In financial time series analysis, the correct identification of model innovations is crucial for further inferences in diverse applications such as risk management analysis. To implement a goodness-of-fit test, we employ the residual-based entropy test generated from the residual empirical process. Since this test often shows size distortions and is affected by parameter estimation, its bootstrap version is considered. It is shown that the bootstrap entropy test is weakly consistent, and thereby its usage is justified. A simulation study and data analysis are conducted by way of an illustration.
DOI: 10.6084/m9.figshare.6530606.v1
title: Bootstrap entropy test for general location-scale time series models with heteroscedasticity

description: This study considers a goodness-of-fit test for location-scale time series models with heteroscedasticity, including a broad class of generalized autoregressive conditional heteroscedastic-type models. In financial time series analysis, the correct identification of model innovations is crucial for further inferences in diverse applications such as risk management analysis. To implement a goodness-of-fit test, we employ the residual-based entropy test generated from the residual empirical process. Since this test often shows size distortions and is affected by parameter estimation, its bootstrap version is considered. It is shown that the bootstrap entropy test is weakly consistent, and thereby its usage is justified. A simulation study and data analysis are conducted by way of an illustration.
DOI: 10.6084/m9.figshare.6530600
title: The role of Wolbachia as a mediator in shaping the reproductive s uccess of its host

description: R script and data table<br>
DOI: 10.6084/m9.figshare.6530600.v1
title: The role of Wolbachia as a mediator in shaping the reproductive s uccess of its host

description: R script and data table<br>
DOI: 10.6084/m9.figshare.6530588
title: Data: Environmental filtering governs the spatial distribution of alien fishes in a large, human-impacted Mediterranean river

description: Fish species data and environmental data (*.csv-files) of the Ebro River and accompanying R-scripts for calculating boosted regression tree models and joint species distribution models (and corresponding plots) used in the study: <br>Radinger J., Alcaraz-Hernández J. D. & García-Berthou E. (2019) Environmental filtering governs the spatial distribution of alien fishes in a large, human-impacted Mediterranean river. <i>Diversity and Distributions</i>. DOI: 10.1111/ddi.12895
DOI: 10.6084/m9.figshare.6530588.v1
title: Data: Environmental filtering governs the spatial distribution of alien fishes in a large, human-impacted Mediterranean river

description: Fish species data and environmental data (*.csv-files) of the Ebro River and accompanying R-scripts for calculating boosted regression tree models and joint species distribution models (and corresponding plots) used in the study: <br>Radinger J., Alcaraz-Hernández J. D. & García-Berthou E. (2019) Environmental filtering governs the spatial distribution of alien fishes in a large, human-impacted Mediterranean river. <i>Diversity and Distributions</i>. DOI: 10.1111/ddi.12895
DOI: 10.6084/m9.figshare.6530504
title: SSR data for Didymella tanaceti 2012 Tasmanian Population

description: .csv file of SSR allele repeat numbers for a <i>Didymella tanaceti </i>population collected in 2012 from Tasmania, Australia. <br>Data is in Genalex format for upload into R program Poppr<br>Isolate column contains code for each individual isolate in population.<br>Pop column indicates the hierarchies which were used for analysis (1_2_3_4_5_6)1: TAS = overall population2: AUG/NOV = sampling time; AUG = August sampling, NOV = November sampling3: SASS/TABLE = location of field; SASS = Sassafrass Tasmania, TABLE = Table Cape Tasmania4: 51907/63242/70047/70046 = field sampled5: 1/2 = Transect sampled in field6: 1/2 = Mating-type of isolate; 1 = Mat1-1, 2 = Mat1-2<br>SSR details are contained in Table 1. <br>
DOI: 10.6084/m9.figshare.6530504.v1
title: SSR data for Didymella tanaceti 2012 Tasmanian Population

description: .csv file of SSR allele repeat numbers for a <i>Didymella tanaceti </i>population collected in 2012 from Tasmania, Australia. <br>Data is in Genalex format for upload into R program Poppr<br>Isolate column contains code for each individual isolate in population.<br>Pop column indicates the hierarchies which were used for analysis (1_2_3_4_5_6)1: TAS = overall population2: AUG/NOV = sampling time; AUG = August sampling, NOV = November sampling3: SASS/TABLE = location of field; SASS = Sassafrass Tasmania, TABLE = Table Cape Tasmania4: 51907/63242/70047/70046 = field sampled5: 1/2 = Transect sampled in field6: 1/2 = Mating-type of isolate; 1 = Mat1-1, 2 = Mat1-2<br>SSR details are contained in Table 1. <br>
DOI: 10.6084/m9.figshare.6530303
title: Additional file 7: of Calculating the statistical significance of rare variants causal for Mendelian and complex disorders

description: Calculating P-values for findings from previous whole-exome or targeted sequencing studies. The parameter f denotes the proportion of individuals in the 1000 Genomes Project dataset who have a rare variant at least as severe as the identified variants. A MAF threshold labeled exclusion refers to studies that did not filter by a given threshold and excluded variants based on their presence in public databases such as dbSNP; in such cases, results were calculated using a MAF threshold of 0.1%. Abbreviations: MAF, minor allele frequency; AD, autosomal dominant; AR, autosomal recessive; XL, X-linked; nonsyn, nonsynonymous variant; LOF, loss-of-function variant; Het, heterozygous; Hom, homozygous; CHet/Hom, compound heterozygous or homozygous. (XLS 44 kb)
DOI: 10.6084/m9.figshare.6530300
title: Additional file 6: of Calculating the statistical significance of rare variants causal for Mendelian and complex disorders

description: List of candidate autism genes. Genes listed were used to produce Fig.Â 5. (XLS 102 kb)
DOI: 10.6084/m9.figshare.6530303.v1
title: Additional file 7: of Calculating the statistical significance of rare variants causal for Mendelian and complex disorders

description: Calculating P-values for findings from previous whole-exome or targeted sequencing studies. The parameter f denotes the proportion of individuals in the 1000 Genomes Project dataset who have a rare variant at least as severe as the identified variants. A MAF threshold labeled exclusion refers to studies that did not filter by a given threshold and excluded variants based on their presence in public databases such as dbSNP; in such cases, results were calculated using a MAF threshold of 0.1%. Abbreviations: MAF, minor allele frequency; AD, autosomal dominant; AR, autosomal recessive; XL, X-linked; nonsyn, nonsynonymous variant; LOF, loss-of-function variant; Het, heterozygous; Hom, homozygous; CHet/Hom, compound heterozygous or homozygous. (XLS 44 kb)
DOI: 10.6084/m9.figshare.6530300.v1
title: Additional file 6: of Calculating the statistical significance of rare variants causal for Mendelian and complex disorders

description: List of candidate autism genes. Genes listed were used to produce Fig.Â 5. (XLS 102 kb)
DOI: 10.6084/m9.figshare.6530273
title: Additional file 3: of Calculating the statistical significance of rare variants causal for Mendelian and complex disorders

description: Variant depletion scores for all protein domain in every gene. For each instance of a protein domain in a gene, we calculated variant depletion scores to identify regions within a gene that may be under differing degrees of evolutionary constraint. (XLS 28555 kb)
DOI: 10.6084/m9.figshare.6530273.v1
title: Additional file 3: of Calculating the statistical significance of rare variants causal for Mendelian and complex disorders

description: Variant depletion scores for all protein domain in every gene. For each instance of a protein domain in a gene, we calculated variant depletion scores to identify regions within a gene that may be under differing degrees of evolutionary constraint. (XLS 28555 kb)
DOI: 10.6084/m9.figshare.6530264
title: Additional file 2: of Calculating the statistical significance of rare variants causal for Mendelian and complex disorders

description: Mean number of individuals mutated for different types of protein domains. We calculated the mean number of individuals (out of 2504 individuals) who carried mutations in a given type of protein domains, averaging per gene. (XLS 2951 kb)
DOI: 10.6084/m9.figshare.6530264.v1
title: Additional file 2: of Calculating the statistical significance of rare variants causal for Mendelian and complex disorders

description: Mean number of individuals mutated for different types of protein domains. We calculated the mean number of individuals (out of 2504 individuals) who carried mutations in a given type of protein domains, averaging per gene. (XLS 2951 kb)
DOI: 10.6084/m9.figshare.6530225
title: Additional file 1: of PD-L1 assessment in pediatric rhabdomyosarcoma: a pilot study

description: Table S1. Clinico-pathological features. A summary of all the clinic-pathological features of the analyzed cohort. Table S2. Characterization of the immune infiltrate contexture. This table display the results of the IHC performed, only on RMS with abundant FFPE material, to characterized the immune contexture of RMS. (ODP 30 kb)
DOI: 10.6084/m9.figshare.6530225.v1
title: Additional file 1: of PD-L1 assessment in pediatric rhabdomyosarcoma: a pilot study

description: Table S1. Clinico-pathological features. A summary of all the clinic-pathological features of the analyzed cohort. Table S2. Characterization of the immune infiltrate contexture. This table display the results of the IHC performed, only on RMS with abundant FFPE material, to characterized the immune contexture of RMS. (ODP 30 kb)
DOI: 10.6084/m9.figshare.6530054
title: Additional file 1: of Socio-demographic and economics factors associated with suicide mortality in Iran, 2001â 2010: application of a decomposition model

description: Table S1. Summary statistics for all the variables include in the analysis. (XLSX 44 kb)
DOI: 10.6084/m9.figshare.6530054.v1
title: Additional file 1: of Socio-demographic and economics factors associated with suicide mortality in Iran, 2001â 2010: application of a decomposition model

description: Table S1. Summary statistics for all the variables include in the analysis. (XLSX 44 kb)
DOI: 10.6084/m9.figshare.6529994
title: Additional file 1 of Soft document clustering using a novel graph covering approach

description: List of PMIDs used for analyses. This is a simple text file containing the PMIDs, separated by newline characters. (CVS 13 kb)
DOI: 10.6084/m9.figshare.6529994.v1
title: Additional file 1 of Soft document clustering using a novel graph covering approach

description: List of PMIDs used for analyses. This is a simple text file containing the PMIDs, separated by newline characters. (CVS 13 kb)
DOI: 10.6084/m9.figshare.6529850
title: Additional file 7: of Modelling the metabolism of protein secretion through the Tat route in Streptomyces lividans

description: Comparison tables and MTF results of simulating Tat secretion using a cost of 80,000 protons per protein. (XLS 3191 kb)
DOI: 10.6084/m9.figshare.6529850.v1
title: Additional file 7: of Modelling the metabolism of protein secretion through the Tat route in Streptomyces lividans

description: Comparison tables and MTF results of simulating Tat secretion using a cost of 80,000 protons per protein. (XLS 3191 kb)
DOI: 10.6084/m9.figshare.6529829
title: Additional file 6: of Modelling the metabolism of protein secretion through the Tat route in Streptomyces lividans

description: Comparison tables for iJV1220. Tables comparing the results obtained using the iJV1220 model for the protein secreting strains with those of the plasmid bearing and wild-type strains. (XLS 11751 kb)
DOI: 10.6084/m9.figshare.6529829.v1
title: Additional file 6: of Modelling the metabolism of protein secretion through the Tat route in Streptomyces lividans

description: Comparison tables for iJV1220. Tables comparing the results obtained using the iJV1220 model for the protein secreting strains with those of the plasmid bearing and wild-type strains. (XLS 11751 kb)
DOI: 10.6084/m9.figshare.6529814
title: Additional file 5: of Modelling the metabolism of protein secretion through the Tat route in Streptomyces lividans

description: MTF and FVA results for iJV1220. Excel file containing the list of metabolites and reactions in model iJV1220, together with the results of MTF and FVA calculations using reference, relaxed and minimal constraints. Relaxed constraints consist in setting the larger exchange limit to 1000 and the minor exchange limit to the reference value, or to the reference value minus one or two standard deviations. Minimal constraints consist in using no limits for exchange reactions except for biomass production and protein secretion). (XLS 2141 kb)
DOI: 10.6084/m9.figshare.6529814.v1
title: Additional file 5: of Modelling the metabolism of protein secretion through the Tat route in Streptomyces lividans

description: MTF and FVA results for iJV1220. Excel file containing the list of metabolites and reactions in model iJV1220, together with the results of MTF and FVA calculations using reference, relaxed and minimal constraints. Relaxed constraints consist in setting the larger exchange limit to 1000 and the minor exchange limit to the reference value, or to the reference value minus one or two standard deviations. Minimal constraints consist in using no limits for exchange reactions except for biomass production and protein secretion). (XLS 2141 kb)
DOI: 10.6084/m9.figshare.6529799
title: Additional file 4: of Modelling the metabolism of protein secretion through the Tat route in Streptomyces lividans

description: Comparison tables for iJV710. Tables comparing results obtained using model iJV710 for the protein secreting strains to those of the wild-type and the plasmid carrying strains. (XLS 4108 kb)
DOI: 10.6084/m9.figshare.6529799.v1
title: Additional file 4: of Modelling the metabolism of protein secretion through the Tat route in Streptomyces lividans

description: Comparison tables for iJV710. Tables comparing results obtained using model iJV710 for the protein secreting strains to those of the wild-type and the plasmid carrying strains. (XLS 4108 kb)
DOI: 10.6084/m9.figshare.6529793
title: Additional file 1: of Evaluation of the quality of care of oncologic patients with pain in palliative and pain units based on the Achievable Benchmarks of Care (ABC): project 25Q

description: 25 questionary-research data. (XLS 97 kb)
DOI: 10.6084/m9.figshare.6529793.v1
title: Additional file 1: of Evaluation of the quality of care of oncologic patients with pain in palliative and pain units based on the Achievable Benchmarks of Care (ABC): project 25Q

description: 25 questionary-research data. (XLS 97 kb)
DOI: 10.6084/m9.figshare.6529787
title: Additional file 3: of Modelling the metabolism of protein secretion through the Tat route in Streptomyces lividans

description: MTF and FVA results for iJV710. Excel file containing: the list of metabolites and reactions considered in the model, the results obtained with the model subject to lower and upper bound constraints using reference values and optimizing for (constrained) biomass production, the results obtained releasing the upper bounds on protein production and optimizing for protein secretion (to maximize the effect of protein production and secretion). (XLS 500 kb)
DOI: 10.6084/m9.figshare.6529787.v1
title: Additional file 3: of Modelling the metabolism of protein secretion through the Tat route in Streptomyces lividans

description: MTF and FVA results for iJV710. Excel file containing: the list of metabolites and reactions considered in the model, the results obtained with the model subject to lower and upper bound constraints using reference values and optimizing for (constrained) biomass production, the results obtained releasing the upper bounds on protein production and optimizing for protein secretion (to maximize the effect of protein production and secretion). (XLS 500 kb)
DOI: 10.6084/m9.figshare.6529784
title: Additional file 2: of Physical activity and sedentary behaviour research in Thailand: a systematic scoping review

description: Data extraction table. The detailed table of all data extracted from each study included in this review. (XLSX 245 kb)
DOI: 10.6084/m9.figshare.6529784.v1
title: Additional file 2: of Physical activity and sedentary behaviour research in Thailand: a systematic scoping review

description: Data extraction table. The detailed table of all data extracted from each study included in this review. (XLSX 245 kb)
DOI: 10.6084/m9.figshare.6529772
title: Additional file 1: of Depression, sexual dysfunction and sexual quality of life in women with infertility

description: SPSS. Data used for analysis in this study. (SAV 28 kb)
DOI: 10.6084/m9.figshare.6529772.v1
title: Additional file 1: of Depression, sexual dysfunction and sexual quality of life in women with infertility

description: SPSS. Data used for analysis in this study. (SAV 28 kb)
DOI: 10.6084/m9.figshare.6529769
title: Additional file 2: of Modelling the metabolism of protein secretion through the Tat route in Streptomyces lividans

description: GSMN models. Zip file containing the new models, iJV710 and iJV1220 in SBML format. As shipped, the models represent the wild-type strain but contain support for the plasmid-carrying and various protein overproducer strains. In order to model these other strains, the limits of the corresponding reactions should be set to appropriate values. (ZIP 389 kb)
DOI: 10.6084/m9.figshare.6529769.v1
title: Additional file 2: of Modelling the metabolism of protein secretion through the Tat route in Streptomyces lividans

description: GSMN models. Zip file containing the new models, iJV710 and iJV1220 in SBML format. As shipped, the models represent the wild-type strain but contain support for the plasmid-carrying and various protein overproducer strains. In order to model these other strains, the limits of the corresponding reactions should be set to appropriate values. (ZIP 389 kb)
DOI: 10.6084/m9.figshare.6529754
title: Additional file 1: of Modelling the metabolism of protein secretion through the Tat route in Streptomyces lividans

description: Experimental growth and secretion data. Excel file containing experimentally determined biomass and protein secretion data for the agarase and α-amylase producing strains. (XLS 11 kb)
DOI: 10.6084/m9.figshare.6529754.v1
title: Additional file 1: of Modelling the metabolism of protein secretion through the Tat route in Streptomyces lividans

description: Experimental growth and secretion data. Excel file containing experimentally determined biomass and protein secretion data for the agarase and α-amylase producing strains. (XLS 11 kb)