cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.24258645
title: Identification of key immune cell-related genes involved in tumorigenesis and prognosis of cervical squamous cell carcinoma

description: The infiltration of immune cells can significantly affect the prognosis and immune therapy of patients with cervical squamous cell carcinoma (CSCC). This study aimed to explore key immune cell-related genes in the tumorigenesis and prognosis of CSCC. The module significantly related to immunity was screened by weighted gene co-expression network analysis (WGCNA) and ESTIMATE analysis, followed by correlation analysis with clinical traits. Key candidate genes were intersected with the protein–protein interaction (PPI) network genes for immune-related genes. The relationship between immune cell infiltration and key genes was analyzed. Tumor immune dysfunction and exclusion (TIDE) and immunophenoscore (IPS) predicted the response to immunotherapy in CSCC patients. Clinically, quantitative real-time polymerase chain reaction (qRT-PCR) and immunohistochemistry were manipulated for analyzing the changes in mRNA and protein expression of key genes in cancer. Western blot was conducted to assess the correlation between key genes and immune infiltration. The brown module was notably associated with the immune microenvironment of CSCC, from which three immune-related key genes (<i>TYROBP</i>, <i>CCL5</i>, and <i>HLA-DRA</i>) were obtained. High expression of these genes was significantly positively associated with the infiltration abundance of T cells, B cells, and other immune cells. High expression levels of three key genes were confirmed in para-cancer tissue and correlated with the abundance of immune cells. The high-expression group of key genes was more sensitive to immunotherapy. We provide a theoretical basis for searching for potential targets for effective treatment and diagnosis of CSCC and provide new ideas for developing novel immunotherapy strategies.
DOI: 10.6084/m9.figshare.24258645.v1
title: Identification of key immune cell-related genes involved in tumorigenesis and prognosis of cervical squamous cell carcinoma

description: The infiltration of immune cells can significantly affect the prognosis and immune therapy of patients with cervical squamous cell carcinoma (CSCC). This study aimed to explore key immune cell-related genes in the tumorigenesis and prognosis of CSCC. The module significantly related to immunity was screened by weighted gene co-expression network analysis (WGCNA) and ESTIMATE analysis, followed by correlation analysis with clinical traits. Key candidate genes were intersected with the protein–protein interaction (PPI) network genes for immune-related genes. The relationship between immune cell infiltration and key genes was analyzed. Tumor immune dysfunction and exclusion (TIDE) and immunophenoscore (IPS) predicted the response to immunotherapy in CSCC patients. Clinically, quantitative real-time polymerase chain reaction (qRT-PCR) and immunohistochemistry were manipulated for analyzing the changes in mRNA and protein expression of key genes in cancer. Western blot was conducted to assess the correlation between key genes and immune infiltration. The brown module was notably associated with the immune microenvironment of CSCC, from which three immune-related key genes (<i>TYROBP</i>, <i>CCL5</i>, and <i>HLA-DRA</i>) were obtained. High expression of these genes was significantly positively associated with the infiltration abundance of T cells, B cells, and other immune cells. High expression levels of three key genes were confirmed in para-cancer tissue and correlated with the abundance of immune cells. The high-expression group of key genes was more sensitive to immunotherapy. We provide a theoretical basis for searching for potential targets for effective treatment and diagnosis of CSCC and provide new ideas for developing novel immunotherapy strategies.
DOI: 10.6084/m9.figshare.24167207
title: Knowledge mapping of therapeutic cancer vaccine from 2013 to 2022: A bibliometric and visual analysis

description: The investigation of therapeutic cancer vaccines has been ongoing for the past century. Herein, we used VOSviewer and CiteSpace to perform the first global bibliometric analysis of the literature on therapeutic cancer vaccines from 2013 to 2022 aiming to explore the current status and potential research trends. The findings revealed a consistent upward trend in both publication counts and citations. The United States emerged as the leading contributor with the highest number of published papers. Additionally, the analysis of references and keywords indicated that therapeutic cancer vaccines have long been popular topics, whereas neoantigen vaccines, mRNA vaccines, combination strategies, and vaccine delivery systems are emerging research hotspots. This bibliometric study provides a comprehensive and important overview of the current knowledge and potential developments in therapeutic cancer vaccines from 2013 to 2022, which may serve as a valuable reference for scholars interested in further exploring this promising field.
DOI: 10.6084/m9.figshare.24167207.v1
title: Knowledge mapping of therapeutic cancer vaccine from 2013 to 2022: A bibliometric and visual analysis

description: The investigation of therapeutic cancer vaccines has been ongoing for the past century. Herein, we used VOSviewer and CiteSpace to perform the first global bibliometric analysis of the literature on therapeutic cancer vaccines from 2013 to 2022 aiming to explore the current status and potential research trends. The findings revealed a consistent upward trend in both publication counts and citations. The United States emerged as the leading contributor with the highest number of published papers. Additionally, the analysis of references and keywords indicated that therapeutic cancer vaccines have long been popular topics, whereas neoantigen vaccines, mRNA vaccines, combination strategies, and vaccine delivery systems are emerging research hotspots. This bibliometric study provides a comprehensive and important overview of the current knowledge and potential developments in therapeutic cancer vaccines from 2013 to 2022, which may serve as a valuable reference for scholars interested in further exploring this promising field.
DOI: 10.6084/m9.figshare.24092323.v1
title: The immunogenicity of the ChAdOx1 nCoV-19 vaccination in participants with underlying comorbidity diseases: A prospective cohort study

description: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) increases mortality rates in older adults and those with comorbidities. Individuals with certain comorbidities may have a poor immune response and require early booster vaccines. We aimed to assess the immune response after two doses of ChAdOx1 nCoV-19 vaccine, at 84-day intervals, in participants with the following comorbidities; diabetes mellitus; obesity; cardiovascular disease; chronic kidney disease; rheumatological disease; cirrhosis; hematological disease; hematological malignancy; or solid malignancy. The study was conducted at Chulabhorn Hospital in Thailand, with healthy healthcare workers serving as the control group. Of the 769 participants, 352 were in the healthy cohort and 417 were in the comorbidity cohort, all received at least one dose of vaccine. Anti-RBD total antibody levels were evaluated on Day 0, Day 84, and Day 112. The results at Day 112 (4 weeks after the second dose) showed that individuals with comorbidities had a poor immune response compared to healthy individuals, especially those with hematological malignancy and solid malignancy. The geometric mean concentration (GMC) of anti-RBD antibody in the comorbidity cohort was significantly lower than that in the healthy cohort: 433.66 BAU/ml (95% CI 334.62–562.01) versus 1096.14 BAU/ml (95% CI 1010.26–1189.33), respectively. The geometric mean ratio (GMR) between the two cohorts was 0.40 (95% CI 0.30–0.52, <i>p</i> &lt; .001). This study concluded that individuals with comorbidities, particularly hematological and solid malignancies, had poor immune responses and may require an early booster vaccine to prevent infection and death.
DOI: 10.15468/dl.y5cttq
title: Occurrence Download

description: A dataset containing 433 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Pentacalia desiderabilis",
 "HasCoordinate is true",
 "OccurrenceStatus is Present",
 {
 "not" : {
 "BasisOfRecord" : [
 "is Fossil"
 ]
 }
 }
 ]
}

 The dataset includes 433 records from 87 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0008561-260208012135463/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.60893/figshare.apl.31098727
title: Supporting Material: Tuning and Suppression of YIG Magnetisation Dynamics via Antiferromagnetic Interface Coupling

description: Additional characterisation and FMR data with additional figures S1 to S4
DOI: 10.15468/dl.jtjmts
title: Occurrence Download

description: A dataset containing 10 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Aspidoras velites",
 "DecimalLatitude is not null",
 "DecimalLongitude is not null"
 ]
}

 The dataset includes 10 records from 5 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0008562-260208012135463/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.5jwc78
title: Occurrence Download

description: A dataset listing the 23662 species recorded in GBIF matching the query:
{
 "DatasetKey" : [
 "is AMNH Bird Collection"
 ]
}

 The dataset's 23662 records were derived from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0008548-260208012135463/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.5281/zenodo.18609776
title: Wildfire Risk for Species under Climate Change

description: Source/plot data and code related to the research article "Wildfire Risk for Species under Climate Change".
DOI: 10.15468/dl.by9tss
title: Occurrence Download

description: A dataset containing 2 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Tritoniopsis flava",
 "HasCoordinate is true",
 "BasisOfRecord is one of (Specimen)"
 ]
}

 The dataset includes 2 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0008563-260208012135463/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.urpnxw
title: Occurrence Download

description: A dataset containing 230 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Mallotus macrostachyus",
 "HasCoordinate is true",
 "OccurrenceStatus is Present",
 {
 "not" : {
 "BasisOfRecord" : [
 "is Fossil"
 ]
 }
 }
 ]
}

 The dataset includes 230 records from 16 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0008564-260208012135463/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.5281/zenodo.18610032
title: Substrate scope and catalytic mechanism of α, β-epoxyketone synthase EpnF illuminated by in situ esterase-mediated deprotection - MD simulations

description: This record contains MD trajectories used in manuscript Substrate scope and catalytic mechanism of α, β-epoxyketone synthase EpnF illuminated by in situ esterase-mediated deprotection" by Callum J. Bullock, Marlene L. Rothe, Joshua W. Cartwright, Munro Passmore, Alex J. Mullins, Fabrizio Alberti, Józef R. Lewandowski, Lona M. Alkhalaf and Gregory L. Challis. 

Simulation 1 contains repeats of 100 ns classical MD of EpnF dimer with fully oxidised FAD in both active site pockets and N-acyl-dipeptidyl β-ketoacid substrate in one of the pockets. Simulation 2 contains repeats of 100 ns classical MD of EpnF dimer with enone intermediate in both pockets and with FADH- in one pocket and FADHO2- in the other pocket. 

The trajectories are in AMBER NetCDF format and are stripped of water and ions. For the details on the simulations see the accompanying paper
DOI: 10.15468/dl.w245j8
title: Occurrence Download

description: A dataset containing 620 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Xiphocolaptes falcirostris"
 ]
}

 The dataset includes 620 records from 19 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0008565-260208012135463/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.5281/zenodo.18610031
title: Substrate scope and catalytic mechanism of α, β-epoxyketone synthase EpnF illuminated by in situ esterase-mediated deprotection - MD simulations

description: This record contains MD trajectories used in manuscript Substrate scope and catalytic mechanism of α, β-epoxyketone synthase EpnF illuminated by in situ esterase-mediated deprotection" by Callum J. Bullock, Marlene L. Rothe, Joshua W. Cartwright, Munro Passmore, Alex J. Mullins, Fabrizio Alberti, Józef R. Lewandowski, Lona M. Alkhalaf and Gregory L. Challis. 

Simulation 1 contains repeats of 100 ns classical MD of EpnF dimer with fully oxidised FAD in both active site pockets and N-acyl-dipeptidyl β-ketoacid substrate in one of the pockets. Simulation 2 contains repeats of 100 ns classical MD of EpnF dimer with enone intermediate in both pockets and with FADH- in one pocket and FADHO2- in the other pocket. 

The trajectories are in AMBER NetCDF format and are stripped of water and ions. For the details on the simulations see the accompanying paper
DOI: 10.15468/dl.kfunm9
title: Occurrence Download

description: A dataset containing 266 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Pleroma echinatum",
 "HasCoordinate is true",
 "OccurrenceStatus is Present",
 {
 "not" : {
 "BasisOfRecord" : [
 "is Fossil"
 ]
 }
 }
 ]
}

 The dataset includes 266 records from 44 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0008566-260208012135463/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.4121/b044bbb9-edf3-476a-b729-e3252bd7ad6d
title: Data underlying the publication: Sortase A-mediated farnesylation of Cdc42 in vitro

description: This dataset contains data collected for the publication <strong>Sortase A-mediated farnesylation of Cdc42 <em>in vitro.</em></strong>This dataset contains the following data:Figure 2a: SDS-PAGE, anti-His blot, anti-Cdc42 blotThe purpose of these SDS-PAGE and blots was to show indirect evidence of presence of the produced desired product Flag-Cdc42-farnesylFigure 3b: Silverstained SDS-PAGE and fluorescence image of SDS-PAGEThe purpose of these SDS-PAGEs was to visualize protein presence per fraction of the liposome co-floatation assay, an assay to show the membrane binding of Flag-Cdc42-farnesyl.Figure 3c: Band intensity data underlying the barplot, calculated barheights and standard error of the means, analysis script used for plottingThe purpose of these barplot was to visualized the quantification of protein presence per fraction of the liposome co-floatation assay, an assay to show the membrane binding of Flag-Cdc42-farnesyl.Figure 4b: Luminescence data underlying the barplot, calculated barheights and standard error of the means, analysis script used for plottingThe purpose of this assay was to show the GTPase activity of Flag-Cdc42-farnesyl and its enhancement of GTPase activity by GEF Cdc24.
DOI: 10.4121/b044bbb9-edf3-476a-b729-e3252bd7ad6d.v1
title: Data underlying the publication: Sortase A-mediated farnesylation of Cdc42 in vitro

description: This dataset contains data collected for the publication <strong>Sortase A-mediated farnesylation of Cdc42 <em>in vitro.</em></strong>This dataset contains the following data:Figure 2a: SDS-PAGE, anti-His blot, anti-Cdc42 blotThe purpose of these SDS-PAGE and blots was to show indirect evidence of presence of the produced desired product Flag-Cdc42-farnesylFigure 3b: Silverstained SDS-PAGE and fluorescence image of SDS-PAGEThe purpose of these SDS-PAGEs was to visualize protein presence per fraction of the liposome co-floatation assay, an assay to show the membrane binding of Flag-Cdc42-farnesyl.Figure 3c: Band intensity data underlying the barplot, calculated barheights and standard error of the means, analysis script used for plottingThe purpose of these barplot was to visualized the quantification of protein presence per fraction of the liposome co-floatation assay, an assay to show the membrane binding of Flag-Cdc42-farnesyl.Figure 4b: Luminescence data underlying the barplot, calculated barheights and standard error of the means, analysis script used for plottingThe purpose of this assay was to show the GTPase activity of Flag-Cdc42-farnesyl and its enhancement of GTPase activity by GEF Cdc24.
DOI: 10.25652/diw_data_s0035.1
title: Untersuchung der sozialen Lage von Selbstständigen in Deutschland
DOI: 10.15468/dl.pvb3vy
title: Occurrence Download

description: A dataset containing 5 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Corydoras acrensis",
 "DecimalLatitude is not null",
 "DecimalLongitude is not null"
 ]
}

 The dataset includes 5 records from 3 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0008567-260208012135463/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.25824/redu/fhtejn
title: Materialidades em transformação: Os tecidos e os bailes entre os Murui-Muina da Amazônia

description: Projeto de pesquisa que estudará as artes do tecido e os bailes de maloca dos Murui- Muina, na fronteira amazônica Brasil – Colômbia, como práticas criativas que envolvem materialidades em transformação. O desafio metodológico está orientado por uma pergunta central: que relação existe entre elaborar um cesto e realizar um baile? Para abordar esta pergunta o projeto identifica quatro caminhos etnográficos de investigação: 1- A prática das artes do tecido e as práticas de realização de baile de maloca, mostram que as materialidades envolvidas (fibras, alimentos, corpos) são susceptíveis de transformação. 2- Tecer cestos, tipitis e peneiras, e fazer baile, mobilizam experiências transformadoras de corpos, corpos que experimentam mudanças nos processos de elaboração e execução das práticas. 3 – As artes do tecido e a realização de baile são manifestações de unidade: fibras e corpos entrelaçados que reforçam vínculos e encontros, forças que organizadas compõem unidade. 4 - As formas de espirais e círculos do tecido e das coreografias do baile aludem, comparativamente, à forma que adquire a temporalidade na perspectiva da memória indígena, a forma espiral na qual surgem e desaparecem pessoas armadas e eventos violentos, mas também as respostas locais perante estas experiências no fluxo da história. Estes quatro caminhos de reflexão permitirão orientar o percurso da pesquisa, a busca das respostas e a participação nos debates relacionados com a criação, a transformação, a memória e as lutas comuns. O estudo será desenvolvido a partir da prática etnográfica com o uso da fotografia e vídeo, pautado pela bibliografia antropológica pertinente e tendo a comparação como perspectiva de análise.
DOI: 10.6084/m9.figshare.31315351
title: VR dataset

description: vegetation restoration data
DOI: 10.6084/m9.figshare.31315351.v1
title: VR dataset

description: vegetation restoration data
DOI: 10.6084/m9.figshare.31083799
title: Raw fluorescence image of malignant synapses

description: This item contains raw fluorescence microscopy images and associated quantitative tables generated for the study of C1QL1-mediated interactions between tumor cells and neurons. The dataset includes immunofluorescence images illustrating synapse-like structures formed at tumor–neuron interfaces, together with corresponding statistical measurements related to synaptic features, including signal intensity, density, and spatial distribution.All images are provided in their original, unprocessed formats, and the accompanying tables contain the numerical data used for downstream statistical analysis and figure generation. These data support the investigation of tumor–neuron malignant synaptic interactions and are intended to facilitate data transparency, reproducibility, and reuse by the cancer neuroscience community.
DOI: 10.6084/m9.figshare.31083799.v2
title: Raw fluorescence image of malignant synapses

description: This item contains raw fluorescence microscopy images and associated quantitative tables generated for the study of C1QL1-mediated interactions between tumor cells and neurons. The dataset includes immunofluorescence images illustrating synapse-like structures formed at tumor–neuron interfaces, together with corresponding statistical measurements related to synaptic features, including signal intensity, density, and spatial distribution.All images are provided in their original, unprocessed formats, and the accompanying tables contain the numerical data used for downstream statistical analysis and figure generation. These data support the investigation of tumor–neuron malignant synaptic interactions and are intended to facilitate data transparency, reproducibility, and reuse by the cancer neuroscience community.
DOI: 10.15468/dl.3dhrq8
title: Occurrence Download

description: A dataset containing 94 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is Malaysia",
 "TaxonKey is Begonia gueritziana"
 ]
}

 The dataset includes 94 records from 11 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0008568-260208012135463/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.6084/m9.figshare.31083799.v1
title: Source data for fluorescence imaging of tumor–neuron malignant synapses involving C1QL1

description: This item contains raw fluorescence microscopy images and associated quantitative tables generated for the study of C1QL1-mediated interactions between tumor cells and neurons. The dataset includes immunofluorescence images illustrating synapse-like structures formed at tumor–neuron interfaces, together with corresponding statistical measurements related to synaptic features, including signal intensity, density, and spatial distribution.All images are provided in their original, unprocessed formats, and the accompanying tables contain the numerical data used for downstream statistical analysis and figure generation. These data support the investigation of tumor–neuron malignant synaptic interactions and are intended to facilitate data transparency, reproducibility, and reuse by the cancer neuroscience community.
DOI: 10.5517/ccdc.csd.cc2p4kq4
title: CCDC 2477046: Experimental Crystal Structure Determination

description: Related Article: Xi longlong|2025|CSD Communication|||
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.