cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.5066/p9psfjyb
title: Estimated Use of Water for Coastal Carolinas Focus Area Study

description: The Cape Fear and Pee Dee River Basins in North Carolina and South Carolina were chosen as a focus area study (FAS) for the U.S. Geological Survey (USGS) National Water Census (NWC) in 2016. The objective of the NWC is to place technical information and tools in the hands of stake holders so that they can make decisions on water availability. The USGS South Atlantic Water Science Center, comprised of North Carolina, South Carolina, and Georgia, conducted a 3-year study of water use and availability to provide information related to the competing societal and ecological water needs in the Southeastern Atlantic Coastal Basins of the Carolinas. The Coastal Carolinas study area includes the Pee Dee and Cape Fear River Basins and the Atlantic Coastal Plain from Brunswick, Georgia, to near Greenville, North Carolina. The study is divided into 5 main components: 1) Societal Water-Use Data Compilation and Refinement, 2) Land-Use, Population, Water-Use and Climate Change Scenarios, 3) Surface-Water Modeling, 4) Ecological Response Modeling, and 5) Groundwater Modeling. One task to meet this objective was to compile water withdrawal and return data by water-use category from local, regional, and state-scale data sources in order to utilize those data in surface-water models, a groundwater model, an ecological flow model, and for predictions of future water needs. This data release contains (1) Groundwater withdrawals for Georgia, South Carolina, and North Carolina aggregated by groundwater MODFLOW model cell area, year, and water-use category; (2) Surface-water withdrawal estimates for years 1983 - 2017 aggregated to the Soil and Water Assessment (SWAT) model catchment level developed for the Pee Dee and Cape Fear River Basins; (3) Wastewater return estimates from years 2000, 2005, 2010, and 2015 aggregated to the Soil and Water Assessment (SWAT) model catchment level developed for the Pee Dee and Cape Fear River Basins; and (4) Surface-water and groundwater off-stream water-use estimates in the Coastal Carolinas study area for selected water-use categories from years 2000, 2005, 2010, and 2015 aggregated to the 8-digit (subbasin) hydrologic unit level within state boundaries in the Coastal Carolinas study area.
DOI: 10.5067/aura/omi/data2027
title: OMI/Aura Surface UV Irradiance 1-orbit L2 Swath 13x24 km
DOI: 10.5281/zenodo.5008187
title: broadinstitute/lincs-cell-painting: Full release of LINCS Cell Painting dataset

description: Summary This release contains finalized profile and metadata information for the CellProfiler-derived features from the LINCS Cell Painting dataset. We assayed two batches of data and applied an image analysis pipeline using CellProfiler to segment cells and extract morphology features. Using the CellProfiler output, we applied an image-based profiling pipeline to process the morphology profiles into an analysis-ready form. In this repository, we provide the full image-based profiling pipeline we used to process the data, as well as most of the intermediate data. Data counts Two batches ("2016_04_01_a549_48hr_batch1" and "2017_12_05_Batch2") 159,717,488 unique cells total 2016_04_01_a549_48hr_batch1 52,223 profiles (batch corrected) 10,752 unique perturbations 1,571 unique compounds 1 time point (48 hour) 7 doses 1 cell line (A549) 110,012,425 unique cells 2017_12_05_Batch2 51,447 profiles (batch corrected) 10,368 unique perturbations 349 unique compounds 3 time points (6 hour, 24 hour, 48 hour) 6 doses 3 cell lines (A549, MCF7, U2OS) 49,705,063 unique cells
DOI: 10.5281/zenodo.6299296
title: Data on flower-pollinator interactions in inflorescences of Tillandsia stricta (Bromeliaceae) in the Atlantic Forest. Rio de janeiro Brazil.

description: Study data on the functional ecology of pollinators in the Atlantic Forest. Rio de janeiro Brazil.
DOI: 10.5281/zenodo.6657640
title: Replication package: 40 Years of Designing Code Comprehension Experiments: A Systematic Mapping Study

description: Replication package | 40 Years of Designing Code Comprehension Experiments: A Systematic Mapping Study
DOI: 10.5439/1440997
title: Calibrated Radar Wind Profiler Precipitation Observations and Vertical Velocity Retrievals

description: A radar wind profiler (RWP) data set collected during the 2-year Department of Energy Atmospheric Radiation Measurement (ARM) Observations and Modeling of the Green Ocean Amazon (GoAmazon2014/5) campaign is used to estimate vertical velocity, designate bulk meteorological echo classification (e.g., convective, stratiform), and provide calibrated radar reflectivity factor Z measurements (calibrated against collocated ground disdrometer and raingauge observations from T3). Additional fields include surface precipitation from rain gauge and ARM InterpolatedSonde streams utilized in the echo classification methods. This dataset follows methods established in Giangrande et al. [2013] and Giangrande et al. [2016] for informing on convective vertical velocities, mass flux and area coverage in Amazon convective cells from ARM RWP systems. If RWP datastreams were unavailable on a given date, files still contain raingauge and InterpolatedSonde information.
DOI: 10.6073/pasta/aecc1ee8fef1d76c8dcb5d24e492afe7
title: Black spruce allometric measurements: 2000 - 2001
DOI: 10.6084/m9.figshare.22352914
title: Supplementary Material for: Design and methodological issues of within-person (split-body) randomized controlled trials evaluating a topical treatment: A systematic review

description: Background Topical drugs are often used as first-line treatment for dermatological conditions. A within-person design may then be well adapted: it consists of randomizing lesions/body sites rather than patients, which are then concomitantly treated by the different drugs compared, reducing inter-group variability and therefore requiring fewer patients than the classical parallel-group trial. Objectives The aim of this review was to provide a methodological overview of within-person randomized trials (WP-RCTs) in dermatology. Methods We searched for eligible trials published between 2017 and 2021 in MEDLINE, Embase and Central in dermatology journals and the 6 highest-impact-factor general medical journals. Two authors selected publications and extracted data independently. Results From 1034 articles identified, we included 54 WP-RCTs, mainly for acne vulgaris, psoriasis, actinic keratosis and atopic dermatitis. In most of the trials, patients had only 2 lesions/body sites. In none of the trials did we detect a potential carry-across effect (known to be the major methodological problem in WP-RCTs). Twelve studies reported a care provider applying the treatment, and in 26 studies, the patients themselves applied the treatment. Finally, we also highlight statistical issues for the statistical analysis: overall, 14 (26.9%) studies used a test for independent observations, thus ignoring the between-lesion correlation. Conclusion Our systematic review highlights that despite the publication of the CONSORT checklist extension for WP-RCTs in 2017, this design is rarely used, and when it is, there are methodological and reporting concerns.
DOI: 10.6084/m9.figshare.23762562
title: Supplementary Material for: Milan Ultrasound Criteria predict relapse of ulcerative colitis in remission

description: Introduction Bowel ultrasound is a non-invasive alternative to endoscopy for assessing the disease activity of ulcerative colitis; however, it is unclear whether bowel ultrasound can predict subsequent relapse from remission. Materials and Methods A retrospective cohort study enrolled patients with ulcerative colitis who underwent bowel ultrasound between July 2018 and July 2021 during clinical remission (patient-reported outcome-2 ≤ 1 and no rectal bleeding) for at least 3 months and were followed up for 1 year. Ultrasonographic findings (bowel wall thickness, bowel wall flow, bowel wall stratification, and enlarged lymph nodes), Milan Ultrasound Criteria, Mayo endoscopic subscore, C-reactive protein, and fecal calprotectin levels and their association with subsequent clinical relapse were assessed. Relapse was defined as rectal bleeding score ≥ 1, stool frequency score ≥ 2, or treatment intensification for symptoms. Results 31% of the patients (18/58) relapsed within 1 year. No single ultrasonographic finding predicted relapse, whereas Milan Ultrasound Criteria &gt; 6.2 (p = 0.019), Mayo endoscopic subscore ≥ 1 (p = 0.013), and fecal calprotectin ≥ 250 μg/g (p = 0.040) were associated with a shorter time to relapse in the log-rank test. Milan Ultrasound Criteria &gt; 6.2 (hazard ratio 3.22; 95% confidence interval 1.14-9.08, p = 0.027) and Mayo endoscopic subscore ≥ 1 (hazard ratio 8.70; 95% confidence interval 1.11-68.1, p = 0.039) showed a higher risk of relapse according to a Cox proportional hazards model. Discussion/Conclusion Bowel ultrasound can predict subsequent clinical relapse from remission in patients with ulcerative colitis using the Milan Ultrasound Criteria.
DOI: 10.6084/m9.figshare.23884491
title: Supplementary Material for: The effect of resolution level and targeted design in the diagnostic performance of prenatal chromosomal microarray analysis

description: Introduction This study was performed to assess the optimal resolution for prenatal testing by array comparative genomic hybridization (aCGH), aiming to balance between maximum diagnostic yield and minimal detection of variants of unknown significance (VOUS). Methods This was a prospective study using data of 2336 fetuses that underwent invasive prenatal diagnosis and the samples were analyzed by aCGH. In total, six different aCGH platforms were studied; four different resolutions (0.18 Mb, 0.5Mb, 1Mb, 2Mb) and two platform designs (whole genome [WG] and targeted). The results of these designs were compared based on their diagnostic yield and VOUS rate. The performance of the different designs was further analyzed according to indication for invasive testing. Results The diagnostic yield of CNVs increased with increasing level of analysis. The detection rates of clinically significant chromosomal abnormalities were almost the same across our targeted array designs; 7.2% with 0.18 Mb backbone/ 0.05 Mb, vs. 7.1% with 0.5 Mb backbone/ 0.05 Mb (p&gt;0.05). However, a significant difference in the rate of VOUS was observed; 9.4% with 0.18 Mb backbone/ 0.05 Mb vs. 6% with 0.5 Mb backbone/ 0.05 Mb (p&lt;0.001). After analyzing the results across different indications for testing, we found that the application of non-targeted platform designs and lower levels of resolution analysis (such as 1Mb WG, or 0.5MbL/1MbG WG) would offer similar diagnostic yield in most cases with major congenital anomalies, with lower VOUS rates. However, the sample size for many indication groups was too small to extract robust associations. Conclusion It appears that the targeted array platform with 0.5Mb backbone resolution and 0.05Mb on targeted gene-rich regions is optimal for routine CMA use in prenatal diagnosis. It may be beneficial to individualize the minimum resolution in specific referral indications, as the indications for invasive prenatal testing may be quite heterogeneous.
DOI: 10.6084/m9.figshare.24004134
title: Supplementary Material for: The impact of cueelicited multisensory imagery on alcohol craving: A randomized controlled trial

description: Introduction: Elaborated Intrusion theory suggests that imagery is central to craving, however, the possibility that cue-elicited multisensory imagery produces such urges has not been studied enough by the literature. Thus, we investigated the role of cue-elicited multisensory imagery on alcohol craving in individuals who are hazardous and social drinkers compared to mental and neutral imagery conditions. Methods: In an online experiment, hazardous and social drinkers (N=348) between 18-45 years old were randomised to multisensory, mental, and neutral imagery exposure. The level of craving intensity was measured before and after imagery exposure. Also, participants rated vividness and sensory features scales after the exposure. Results: The level of craving was significantly higher in multisensory imagery condition compared to neutral condition (b=1.94, p&lt;.001, SE=0.30, t(344)=6.52, standardized mean difference (SMD)=0.89 and in mental imagery condition compared to neutral condition (b=1.82, SE=0.30, t(344)=6.52, p&lt;.001, SMD=0.83). The difference between the level of craving intensity between the multisensory and mental was not significant (b=0.12, SE=0.22, t(344)=0.53, p=.594, SMD=0.06). Moreover, craving intensity in response to multisensory versus neutral imagery was significantly stronger among hazardous drinkers (b=-2,90, SE=0.83, t(341)=-3.50, p&lt;.001). The level of vividness was not significantly different between any conditions. The difference between levels of sensory features was higher in multisensory imagery condition compared to neutral (b=0.95, SE=0.30, t(345)=3.17, p=.002, SMD=0.49) and mental imagery condition (b=0.67, SE=0.23, t(345)=2.36, p=0.004, SMD=0.35). Conclusion: Results suggest that cue-elicited multisensory imagery may be a useful tool for eliciting alcohol craving responses and provide an additional means for better understanding the multi-layered mechanism of craving.
DOI: 10.6084/m9.figshare.24124992
title: Supplementary Material for: Survival outcomes of Mohs surgery versus wide local excision for less common nonmelanoma skin cancers: A stabilized inverse probability of treatment weighting analysis

description: Objectives: To compare the survival outcomes of Mohs micrographic surgery (MMS) and wide local excision (WLE) for less common nonmelanoma skin cancers (NMSCs). Methods: This study retrospectively analyzed data from the Surveillance, Epidemiology, and End Results dataset between 2003 and 2018. The less common NMSCs include Merkel cell carcinoma, skin appendage neoplasm, fibromatous malignancy, and other rare NMSCs. The stabilized inverse probability of treatment weighting (SIPTW) and the Kaplan–Meier methods were adopted to assess the overall survival (OS) and cancer-specific survival (CSS). Furthermore, the Cox proportional hazards, Fine-and-Gray regression analysis, and subgroup analysis models were applied to examine the effects of MMS vs. WLE based on all-cause and cancer-specific mortality. Results: We identified 6582 individuals with less common NMSCs for survival analysis, among which 1946 patients (29.5%) had undergone MMS and 4636 (70.5%) had received WLE. Diseases diagnosed in the most recent year, older age, the White race, married status, eyelid/face site, small tumor size, and localized disease were factors significantly associated with MMS treatment. Compared with the WLE group, the MMS group had comparable OS before and after the SIPTW analysis. Additionally, after adjusting for other confounding covariates, the surgery type (WLE vs. MMS) did not show significant associations with all-cause mortality (hazard ratio [HR]: 1.03, 95% confidence interval [CI]: 0.94–1.14, P = 0.517) and disease-specific mortality (HR: 1.16, 95% CI: 0.95–1.42, P = 0.134). Moreover, the subgroup analysis validated these findings. Conclusion: MMS and WLE have comparable OS and CSS for less common NMSCs.
DOI: 10.6084/m9.figshare.24125616
title: Supplementary Material for: Association between sleep and Alzheimer’s disease: A bibliometric analysis from 2003 to 2022

description: Introduction: Alzheimer’s disease (AD) often presents with sleep disorders, which are also an important risk factor for AD, affecting cognitive function to a certain extent. This study aimed to reveal the current global status, present hotspots, and discuss emerging trends of sleep and AD using a bibliometric approach. Methods: Research and review articles related to sleep and AD from 2003 to 2022 were extracted from the Web of Science Core Collection. VOSviewer 1.6.18.0, Scimago Graphica, and CiteSpace 6.2.R2 were used to map the productive and highly cited countries, institutions, journals, authors, references, and keywords in the field. Results: Overall, 4,008 publications were included in this bibliometric analysis. The number of publications and citations showed an increasing trend over the past two decades. The USA and China had the largest and second largest, respectively, number of publications and citations and cooperated with other countries more closely. Ancoli-Israel Sonia published the most papers, and Holtzman David M was co-cited most frequently. The most productive journal was Journal of Alzheimer’s Disease, and Neurology was the most frequently cited journal. The risk factors, β-amyloid, tau, neuroinflammation, astrocytes, glymphatic system, orexin, functional connectivity, and management have been the main research directions of researchers over the past few years and may be the future trend of valuable research. Conclusion: We identified hotspots and emerging trends including risk factors, Aβ, tau, neuroinflammation, the glymphatic system, orexin, and management, which may help identify new therapeutic targets and improve clinical efficacy of sleep and AD.
DOI: 10.25582/data.2020-09.2048641/2019479
title: Data for EMSL Project 51126 from September 2020
DOI: 10.6084/m9.figshare.23640984
title: Supplementary Material for: ECTOPIC CUSHING’S SYNDROME SECONDARY TO ACINIC CELL CARCINOMA OF THE PAROTID GLAND: A CASE-REPORT

description: Ectopic secretion of adrenocorticotropic hormone (ACTH) by non-pituitary tumours is a rare cause of Cushing’s syndrome (CS). We present a case report of a patient with a rare high-grade transformation of an acinic cell carcinoma (ACC) of the parotid gland, who developed CS as a result of ectopic secretion of ACTH by the tumour. The hypercortisolism was successfully treated with metyrapone, and the ACC was treated with local radiotherapy and a combined six cycles of gemcitabine and cisplatin, with partial response of the tumour. A multidisciplinary approach and combined medical treatment with radiotherapy were essential for disease control and CS management. ACC should be considered in the differential diagnosis of ectopic CS.
DOI: 10.25582/data.2020-09.2049866/2019480
title: Data for EMSL Project 51126 from September 2020
DOI: 10.25582/data.2020-09.2050184/2019481
title: Data for EMSL Project 51126 from September 2020
DOI: 10.6084/m9.figshare.23741352
title: Supplementary Material for: Detection of Hybrid Fusion Transcripts, Aberrant Transcript Expression and Specific Single Nucleotide Variants in Acute Leukemia and Myeloid Disorders with Recurrent Gene Rearrangements.

description: Introduction: A variety of gene rearrangements and molecular alterations are key drivers in the pathobiology of acute leukemia and myeloid disorders; current classification systems increasingly incorporate these findings in diagnostic algorithms. Therefore, clinical laboratories require versatile tools, which can detect an increasing number and variety of molecular and cytogenetic alterations of clinical significance. Methods: We validated an RNA-based NGS assay that enables the detection of: i) numerous hybrid fusion transcripts (including rare/novel gene partners), ii) aberrantly expressed EVI1(MECOM) and IKZF1 (Del Exons 4-7) transcripts, and iii) hotspot variants in KIT, ABL1, NPM1 (relevant in the context of gene rearrangement status). Results: For hybrid fusion transcripts, the assay showed 98-100% concordance for known positive and negative samples, with an analytical sensitivity (ie, limit of detection) of approximately 0.8% cells. Cases with underlying EVI1 (MECOM) translocations demonstrated increased EVI1(MECOM) expression. Aberrant IKZF1 (Del Exons 4-7) transcripts detectable with the assay were also present on orthogonal RT-PCR. Specific hotspot mutations in KIT, ABL1 and NPM1 detected with the assay showed 100% concordance with orthogonal testing. Lastly, several illustrative cases are included to highlight the assay’s clinically relevant contributions to patient work-up. Discussion/Conclusion: Through its ability to simultaneously detect various gene rearrangements, aberrantly expressed transcripts and hotspot mutations, this RNA-based NGS assay is a valuable tool for clinical laboratories to supplement other molecular and cytogenetic methods used in the diagnostic workup, and in clinical research, for patients with acute leukemia and myeloid disorders.
DOI: 10.25582/data.2020-09.2049553/2019482
title: Data for EMSL Project 51126 from September 2020
DOI: 10.25582/data.2020-09.2049290/2019483
title: Data for EMSL Project 51126 from September 2020
DOI: 10.25582/data.2020-09.2049355/2019484
title: Data for EMSL Project 51126 from September 2020
DOI: 10.25582/data.2020-09.2049457/2019485
title: Data for EMSL Project 51126 from September 2020
DOI: 10.25582/data.2020-09.2050177/2019486
title: Data for EMSL Project 51126 from September 2020
DOI: 10.25582/data.2020-09.2049451/2019487
title: Data for EMSL Project 51126 from September 2020
DOI: 10.25582/data.2020-09.2049892/2019488
title: Data for EMSL Project 51126 from September 2020
DOI: 10.25582/data.2020-09.2049569/2019489
title: Data for EMSL Project 51126 from September 2020
DOI: 10.25582/data.2020-09.2049420/2019490
title: Data for EMSL Project 51126 from September 2020
DOI: 10.25582/data.2020-09.2050459/2019491
title: Data for EMSL Project 51126 from September 2020
DOI: 10.25582/data.2020-09.2049808/2019492
title: Data for EMSL Project 51126 from September 2020
DOI: 10.25582/data.2020-09.2048646/2019493
title: Data for EMSL Project 51126 from September 2020
DOI: 10.25582/data.2020-09.2048657/2019494
title: Data for EMSL Project 51126 from September 2020
DOI: 10.25582/data.2020-09.2049590/2019495
title: Data for EMSL Project 51126 from September 2020
DOI: 10.25582/data.2020-09.2049686/2019496
title: Data for EMSL Project 51126 from September 2020
DOI: 10.25582/data.2020-09.2049599/2019497
title: Data for EMSL Project 51126 from September 2020
DOI: 10.25582/data.2020-09.2049738/2019498
title: Data for EMSL Project 51126 from September 2020
DOI: 10.25582/data.2020-09.2049765/2019499
title: Data for EMSL Project 51126 from September 2020
DOI: 10.25582/data.2020-09.2049347/2019500
title: Data for EMSL Project 51126 from September 2020
DOI: 10.25582/data.2020-09.2049438/2019501
title: Data for EMSL Project 51126 from September 2020
DOI: 10.25582/data.2020-09.2049449/2019502
title: Data for EMSL Project 51126 from September 2020
DOI: 10.25582/data.2020-09.2049642/2019503
title: Data for EMSL Project 51126 from September 2020
DOI: 10.25582/data.2020-09.2049898/2019504
title: Data for EMSL Project 51126 from September 2020
DOI: 10.25582/data.2020-07.2024217/2019505
title: Data for EMSL Project 51126 from July 2020
DOI: 10.25582/data.2020-09.2048571/2019506
title: Data for EMSL Project 51126 from September 2020
DOI: 10.25582/data.2020-09.2049245/2019507
title: Data for EMSL Project 51126 from September 2020
DOI: 10.25582/data.2020-09.2048428/2019508
title: Data for EMSL Project 51126 from September 2020
DOI: 10.25582/data.2020-09.2049788/2019509
title: Data for EMSL Project 51126 from September 2020
DOI: 10.25582/data.2020-09.2048477/2019510
title: Data for EMSL Project 51126 from September 2020
DOI: 10.25582/data.2020-09.2049382/2019511
title: Data for EMSL Project 51126 from September 2020
DOI: 10.25582/data.2020-09.2049222/2019512
title: Data for EMSL Project 51126 from September 2020
DOI: 10.25582/data.2020-09.2049648/2019513
title: Data for EMSL Project 51126 from September 2020
DOI: 10.25582/data.2020-09.2049716/2019514
title: Data for EMSL Project 51126 from September 2020
DOI: 10.25582/data.2020-09.2049587/2019515
title: Data for EMSL Project 51126 from September 2020
DOI: 10.25582/data.2020-09.2050461/2019516
title: Data for EMSL Project 51126 from September 2020
DOI: 10.25582/data.2020-09.2049614/2019517
title: Data for EMSL Project 51126 from September 2020
DOI: 10.25582/data.2020-07.2024196/2019518
title: Data for EMSL Project 51126 from July 2020
DOI: 10.25582/data.2020-09.2048544/2019519
title: Data for EMSL Project 51126 from September 2020
DOI: 10.25582/data.2020-09.2049552/2019520
title: Data for EMSL Project 51126 from September 2020