cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.25487477
title: Evaluating neurosurgical training: a national survey examining the British trainee experience

description: Neurosurgery training in the UK has undergone significant changes over the past few years, including the new competency-based curriculum and a reduction of elective operating due to the pandemic. We conducted a comprehensive survey to assess UK neurosurgical trainees’ experiences and perceptions to develop targeted action plans. An online anonymised survey was developed and distributed amongst the BNTA mailing list. Question types included 10-point Likert scales and free text options. Descriptive statistics, non-parametric testing of Likert scores, and Spearman’s rank correlation were used to analyse responses. Pearson’s chi-squared test was used for subgroup analysis of categorical data. A total of 75 trainees with a National Training Number (NTN) responded. Overall trainees feel they are well trained, well supported, and have caught up with training emerging out of COVID. Funding for training varied between deaneries. There is significant concern amongst trainees regarding the workforce crisis. This, as well as financial concerns are leading to more than a quarter of trainees considering quitting. Half of the trainees are considering going OOP. More than one third of the trainees and more than half of the female trainees are considering working Less Than Full Time (LTFT). Most important supportive mechanisms towards completion of training were social support, along with personal satisfaction from work. An independent mentoring scheme is a preferred additional support mechanism. Overall training experience for neurosurgery trainees in UK and Ireland was positive. There are significant concerns regarding the workforce crisis and costs of training, with a large proportion of neurosurgery trainees considering resigning. OOP and LTFT are popular means of becoming more competitive for consultant posts and to spend time with their families. Deanery experience, senior and peer support does, and will improve trainee experience and protect against attrition.
DOI: 10.6084/m9.figshare.25487477.v1
title: Evaluating neurosurgical training: a national survey examining the British trainee experience

description: Neurosurgery training in the UK has undergone significant changes over the past few years, including the new competency-based curriculum and a reduction of elective operating due to the pandemic. We conducted a comprehensive survey to assess UK neurosurgical trainees’ experiences and perceptions to develop targeted action plans. An online anonymised survey was developed and distributed amongst the BNTA mailing list. Question types included 10-point Likert scales and free text options. Descriptive statistics, non-parametric testing of Likert scores, and Spearman’s rank correlation were used to analyse responses. Pearson’s chi-squared test was used for subgroup analysis of categorical data. A total of 75 trainees with a National Training Number (NTN) responded. Overall trainees feel they are well trained, well supported, and have caught up with training emerging out of COVID. Funding for training varied between deaneries. There is significant concern amongst trainees regarding the workforce crisis. This, as well as financial concerns are leading to more than a quarter of trainees considering quitting. Half of the trainees are considering going OOP. More than one third of the trainees and more than half of the female trainees are considering working Less Than Full Time (LTFT). Most important supportive mechanisms towards completion of training were social support, along with personal satisfaction from work. An independent mentoring scheme is a preferred additional support mechanism. Overall training experience for neurosurgery trainees in UK and Ireland was positive. There are significant concerns regarding the workforce crisis and costs of training, with a large proportion of neurosurgery trainees considering resigning. OOP and LTFT are popular means of becoming more competitive for consultant posts and to spend time with their families. Deanery experience, senior and peer support does, and will improve trainee experience and protect against attrition.
DOI: 10.6084/m9.figshare.25243264
title: Locating the ventral intermediate thalamic nucleus for deep brain stimulation surgery: analysis of a case series comparing CT and MR targeting

description: Deep brain stimulation (DBS) surgery targeting the ventral intermediate thalamic nucleus (Vim) has proven efficacy in the treatment of tremor. The primary aim is to investigate whether there is a statistically significant difference in patient outcomes when CT-guided targeting of the Vim is compared with MRI-guided targeting. This is a retrospective study concerning patients undergoing Vim-targeted DBS at the Department of Neurosurgery, Royal Victoria Infirmary in Newcastle (9<sup>th</sup> August 2012 to 4<sup>th</sup> January 2019). Fahn–Tolosa–Marin Tremor Scale (FTM TS) and EQ-5D scores were collected from patient notes. Statistical analysis was performed using IBM<sup>®</sup> SPSS<sup>®</sup> Statistics Version 24. Independent samples <i>t</i>-tests were used to compare means. Independent samples <i>t</i>-test did not reveal a statistically significant difference between CT (<i>n</i> = 10; FTM TS mean = 65.40, SD = 11.40; EQ-5D mean = 39.50, SD = 17.87) and MR (<i>n</i> = 7; FTM TS mean = 60.57, SD = 7.50; EQ-5D mean = 32.14, SD = 9.94) groups in pre-surgery FTM TS (t(15) = 0.977, <i>p</i> = 0.344) and EQ-5D (t(15) = 0.982, <i>p</i> = 0.342) scores. No statistically significant difference between the CT (FTM TS mean = 24.12, SD = 20.47; EQ-5D mean = 75.56, SD = 15.63) and MR (FTM TS mean = 22.86, SD = 6.72; EQ-5D mean = 70.43, SD = 15.48) groups was revealed at 1 year assessment of FTM TS (t(14) = 0.155, <i>p</i> = 0.879) and EQ-5D (t(14) = 0.654, <i>p</i> = 0.524). The median difference between pre- and post-surgery FTM TS and EQ-5D scores in the CT group at 1 year was 43.00 and 35.00, respectively. The MR patient group median difference in pre- and post-surgery at 1 year was 35.00 and 35.00 respectively. No statistically significant difference between CT and MR image-guided targeting patient groups was detected.
DOI: 10.6084/m9.figshare.25243264.v1
title: Locating the ventral intermediate thalamic nucleus for deep brain stimulation surgery: analysis of a case series comparing CT and MR targeting

description: Deep brain stimulation (DBS) surgery targeting the ventral intermediate thalamic nucleus (Vim) has proven efficacy in the treatment of tremor. The primary aim is to investigate whether there is a statistically significant difference in patient outcomes when CT-guided targeting of the Vim is compared with MRI-guided targeting. This is a retrospective study concerning patients undergoing Vim-targeted DBS at the Department of Neurosurgery, Royal Victoria Infirmary in Newcastle (9<sup>th</sup> August 2012 to 4<sup>th</sup> January 2019). Fahn–Tolosa–Marin Tremor Scale (FTM TS) and EQ-5D scores were collected from patient notes. Statistical analysis was performed using IBM<sup>®</sup> SPSS<sup>®</sup> Statistics Version 24. Independent samples <i>t</i>-tests were used to compare means. Independent samples <i>t</i>-test did not reveal a statistically significant difference between CT (<i>n</i> = 10; FTM TS mean = 65.40, SD = 11.40; EQ-5D mean = 39.50, SD = 17.87) and MR (<i>n</i> = 7; FTM TS mean = 60.57, SD = 7.50; EQ-5D mean = 32.14, SD = 9.94) groups in pre-surgery FTM TS (t(15) = 0.977, <i>p</i> = 0.344) and EQ-5D (t(15) = 0.982, <i>p</i> = 0.342) scores. No statistically significant difference between the CT (FTM TS mean = 24.12, SD = 20.47; EQ-5D mean = 75.56, SD = 15.63) and MR (FTM TS mean = 22.86, SD = 6.72; EQ-5D mean = 70.43, SD = 15.48) groups was revealed at 1 year assessment of FTM TS (t(14) = 0.155, <i>p</i> = 0.879) and EQ-5D (t(14) = 0.654, <i>p</i> = 0.524). The median difference between pre- and post-surgery FTM TS and EQ-5D scores in the CT group at 1 year was 43.00 and 35.00, respectively. The MR patient group median difference in pre- and post-surgery at 1 year was 35.00 and 35.00 respectively. No statistically significant difference between CT and MR image-guided targeting patient groups was detected.
DOI: 10.6084/m9.figshare.25562104
title: Impact of antithrombotic agents on outcomes in patients requiring surgery for chronic subdural haematoma: a systematic review and meta-analysis

description: A chronic subdural haematoma (CSDH) is a collection of aged blood between the dura and the brain, typically treated with surgical evacuation. Many patients with CSDH have comorbidities requiring the use of antithrombotic medications. The optimal management of these medications in the context of CSDH remains unknown, as the risk of recurrence must be carefully weighed against the risk of vaso-occlusive events. To better understand these risks and inform the development of clinical practice guidelines, we conducted a systematic review and meta-analysis. A systematic review was conducted in accordance with the PRISMA guidelines, searching Medline and Embase databases. The study was registered with PROSPERO (CRD42023397061). A total of 44 studies were included, encompassing 1 prospective cohort study and 43 retrospective cohort studies. Pooled odds ratios (ORs) were calculated for CSDH recurrence and vaso-occlusive events in patients taking anticoagulant or antiplatelet medications compared to patients not receiving antithrombotic therapy. GRADE was used to assess the quality of evidence. In patients on anticoagulant therapy at CSDH diagnosis, the pooled OR for CSDH recurrence was 1.41 (95% CI 1.11 to 1.79; <i>I</i>2 = 28%). For patients on antiplatelet therapy, the pooled OR was 1.31 (95% CI 1.08 to 1.58; <i>I</i>2 = 32%). Patients taking antithrombotic medications had a significantly higher risk of vaso-occlusive events, with a pooled OR of 3.74 (95% CI 2.12 to 6.60; <i>I<sup>2</sup></i> = 0%). There was insufficient evidence to assess the impact of time to recommence antithrombotic medication on CSDH outcomes. We found that baseline antithrombotic use is associated with the risk of CSDH recurrence and vaso-occlusive events following surgical evacuation. The evidence base is of low quality, and decisions regarding antithrombotic therapy should be individualised for each patient. Further high-quality, prospective studies or registry-based designs are needed to better inform clinical decision-making and establish evidence-based guidelines.
DOI: 10.6084/m9.figshare.25562104.v1
title: Impact of antithrombotic agents on outcomes in patients requiring surgery for chronic subdural haematoma: a systematic review and meta-analysis

description: A chronic subdural haematoma (CSDH) is a collection of aged blood between the dura and the brain, typically treated with surgical evacuation. Many patients with CSDH have comorbidities requiring the use of antithrombotic medications. The optimal management of these medications in the context of CSDH remains unknown, as the risk of recurrence must be carefully weighed against the risk of vaso-occlusive events. To better understand these risks and inform the development of clinical practice guidelines, we conducted a systematic review and meta-analysis. A systematic review was conducted in accordance with the PRISMA guidelines, searching Medline and Embase databases. The study was registered with PROSPERO (CRD42023397061). A total of 44 studies were included, encompassing 1 prospective cohort study and 43 retrospective cohort studies. Pooled odds ratios (ORs) were calculated for CSDH recurrence and vaso-occlusive events in patients taking anticoagulant or antiplatelet medications compared to patients not receiving antithrombotic therapy. GRADE was used to assess the quality of evidence. In patients on anticoagulant therapy at CSDH diagnosis, the pooled OR for CSDH recurrence was 1.41 (95% CI 1.11 to 1.79; <i>I</i>2 = 28%). For patients on antiplatelet therapy, the pooled OR was 1.31 (95% CI 1.08 to 1.58; <i>I</i>2 = 32%). Patients taking antithrombotic medications had a significantly higher risk of vaso-occlusive events, with a pooled OR of 3.74 (95% CI 2.12 to 6.60; <i>I<sup>2</sup></i> = 0%). There was insufficient evidence to assess the impact of time to recommence antithrombotic medication on CSDH outcomes. We found that baseline antithrombotic use is associated with the risk of CSDH recurrence and vaso-occlusive events following surgical evacuation. The evidence base is of low quality, and decisions regarding antithrombotic therapy should be individualised for each patient. Further high-quality, prospective studies or registry-based designs are needed to better inform clinical decision-making and establish evidence-based guidelines.
DOI: 10.15468/byrhmv
title: Guaymas Basin and Sonora Margin sediment Targeted loci

description: Our proposed microbial analyses of Guaymas Basin and Sonora Margin subsurface sediments are guided by the working hypothesis that microbial communities will change in composition and metabolic potential, as hydrothermal activity decreases across the ridge flanks, chemical and thermal gradients are attenuated, and substrate availability changes. We propose that the distinctly different lithological and hydrothermal histories of these sediments, and their depositional contexts and changing quality and quantity of buried organic matter will affect the microbial community composition and activity.PI: Andreas Teske
DOI: 10.15468/dl.tpahju
title: Occurrence Download

description: A dataset containing 3 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Descurainia pinnata",
 "Country is Japan",
 "HasCoordinate is true"
 ]
}

 The dataset includes 3 records from 3 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0009148-250920141307145/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/wtmap7
title: Benthic microbial communities in the sediments of the Southern Ocean

description: To investigation benthic microbial communities in the sediments of the Southern Ocean underlying Phaeocysis bloom.
DOI: 10.15468/dl.pb9kpg
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Descurainia pinnata",
 "Country is Sweden",
 "HasCoordinate is true"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0009150-250920141307145/datasets/export for details.
DOI: 10.15468/dl.6zxjsv
title: Occurrence Download

description: A dataset containing 2459797 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is Philippines",
 "HasCoordinate is true",
 "HasGeospatialIssue is false"
 ]
}

 The dataset includes 2459797 records from 939 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0009042-250920141307145/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/5gyug4
title: algal_mat_microbiome_east_antarctica

description: Amplicon sequencing dataset (Illumina MiSeq) targeting Bacteria (16S ssu rRNA) and Eukaryotes (18S ssu rRNA) in microbial mat samples (n=13) from in and around lakes in East Antarctica (Langhovde and Skarvness regions).
DOI: 10.15468/p32y2y
title: Arbuscular mycorrhizal fungi from 150 German grassland and 150 German forest plots from 2011, 2014 and 2017 (Illumina MiSeq)

description: The German Biodiversity Exploratories aim to regularly monitor arbuscular mycorrhizal in German soils. The project considers 150 grassland and 150 forest plots in total, which are distributed along a north-south transect across Germany. The three sites, each consisting of 50 grassland and 50 forest plots, are Schorfheide-Chorin in Northern Germany, Hainich-Duen in Central Germany and Swabian Alb in the South of the country. Grasslands and forests are characterized by different land-use intensities and management regimes, respectively.The arbuscular mycorrhiza fungi were assessed using Illumina MiSeq sequencing of the small subunit (SSU) gene after a joint soil sampling carried out in May 2011, 2014 and 2017, each time on all 300 plots.
DOI: 10.15468/dl.tnp9hr
title: Occurrence Download

description: A dataset containing 6405 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Phellodendron amurense",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present"
 ]
}

 The dataset includes 6405 records from 185 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0009151-250920141307145/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/lxu0n6
title: Robertson Glacier Targeted Locus (Loci)

description: cbbL transcript amplicons from Robertson Glacier, Alberta, Canada subglacial sediment sampled in 2010
DOI: 10.15468/ar7wwx
title: COI data from: Invasive species detection along coastal harbours in northern region of Vastra Gotaland 2024

description: Environmental DNA sequence data of invasive species along the harbors in the northern regions of Vastra Gotaland. Sequence data was obtained from both water samples, and plankton samples of two sampling events, one in the summer and one in the autumn of 2024. The amplicons were amplified by COI Leray-XT primers: Wangensteen et al. 2018 and annotated against an inhouse database of invasive and non-indigenous species of Norway, Sweden and EEA created with EchoPipe: Stensrud et al. in press. The data was created for Länsstyrelsen Vastra Gotaland and financed through HaV.This dataset was published via the SBDI ASV portal.
DOI: 10.15468/bksacn
title: Southern Ocean

description: Southern Ocean bacterioplankton community
DOI: 10.15468/3k4dy1
title: Marine phytoplankton Metagenome

description: Marine phytoplankton in the northern ECS and coastal waters near Jeju from April 24~30th, 2011
DOI: 10.15468/uiflyg
title: estuary metagenome Raw sequence reads

description: Anaerobic Dechlorination of Tetrachlorobisphenol A
DOI: 10.15468/omoqy6
title: ZRD sediment metagenome Metagenome

description: To investigate the influence of wetland types on the composition and structure of microbial communities.
DOI: 10.15468/ox86z5
title: Atlantic salmon microbiota

description: Atlantic salmon skin mucus and surrounding water have been sampled at production facilities both in freshwater and after transfer to seawater. Extracted DNA is sequenced using barcoded 16S primers using PacBio SCC.
DOI: 10.15468/dl.vp5w5z
title: Occurrence Download

description: A dataset containing 35 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Diplotaxis virgata",
 "Country is Belgium",
 "HasCoordinate is true"
 ]
}

 The dataset includes 35 records from 3 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0009152-250920141307145/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.m97qm6
title: Occurrence Download

description: A dataset containing 2744 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is Spain",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "License is one of (CC0 1.0, CC-BY 4.0)",
 "TaxonKey is Meles meles"
 ]
}

 The dataset includes 2744 records from 19 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0009153-250920141307145/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/juxeoj
title: marine sediment metagenome Raw sequence reads

description: South China Sea sediment core microbial diversity
DOI: 10.5281/zenodo.17185403
title: Raw data of La Garrotxa Volcanic Field (NE Iberia) Pleistocene lava-flows
DOI: 10.5281/zenodo.17185402
title: Raw data of La Garrotxa Volcanic Field (NE Iberia) Pleistocene lava-flows
DOI: 10.15468/sjodls
title: Microbial eukaryotes present in a Norwegian coastal ecosystem and in the gut content of Calanus copepods from Raunefjorden

description: Use metabarcoding to characterize the diversity of Calanus prey relative to the total microbial eukaryote diversity in the co-occurring seawater habitat
DOI: 10.5281/zenodo.15631269
title: Bioluminescence based Proximity labeling Enzyme

description: Mapping protein–protein interactions (PPIs) in living systems is critical for understanding dynamic biological processes. While proximity-labeling enzymes like TurboID and APEX2 are widely used, their dependence on reactive chemicals, or large fusion domains limits in vivo applications, especially in deep tissues.

Here, we introduce LucID (Light-free Unifying Catalytic Integrated Domain) – a compact, self-contained proximity-labeling system that functions independently of light or external ROS. LucID was engineered by embedding a minimal catalytic motif derived from TurboID into a NanoLuc scaffold, preserving bioluminescence while enabling spatially confined biotinylation. Upon luciferin addition, LucID leverages BRET (bioluminescence resonance energy transfer) to uncage the catalytic site and activate biotin transfer.

With a molecular weight of approximately 23.7 kDa (40% smaller than TurboID), LucID is optimized for delivery via mRNA-LNP platforms. Its modularity and light-independent activation make it a unique tool for real-time interactome mapping in live cells and deep tissues. LucID introduces a new paradigm in proximity labeling: compact, luminescent, and chemically programmable. By integrating catalytic motifs into a light-producing scaffold, LucID enables temporally precise, spatially confined interactome mapping in challenging biological contexts. This innovation holds promise for single-cell proteomics, in vivo interaction studies, and next-generation bioimaging tools.
DOI: 10.5281/zenodo.15631268
title: Bioluminescence based Proximity labeling Enzyme

description: Mapping protein–protein interactions (PPIs) in living systems is critical for understanding dynamic biological processes. While proximity-labeling enzymes like TurboID and APEX2 are widely used, their dependence on reactive chemicals, or large fusion domains limits in vivo applications, especially in deep tissues.

Here, we introduce LucID (Light-free Unifying Catalytic Integrated Domain) – a compact, self-contained proximity-labeling system that functions independently of light or external ROS. LucID was engineered by embedding a minimal catalytic motif derived from TurboID into a NanoLuc scaffold, preserving bioluminescence while enabling spatially confined biotinylation. Upon luciferin addition, LucID leverages BRET (bioluminescence resonance energy transfer) to uncage the catalytic site and activate biotin transfer.

With a molecular weight of approximately 23.7 kDa (40% smaller than TurboID), LucID is optimized for delivery via mRNA-LNP platforms. Its modularity and light-independent activation make it a unique tool for real-time interactome mapping in live cells and deep tissues. LucID introduces a new paradigm in proximity labeling: compact, luminescent, and chemically programmable. By integrating catalytic motifs into a light-producing scaffold, LucID enables temporally precise, spatially confined interactome mapping in challenging biological contexts. This innovation holds promise for single-cell proteomics, in vivo interaction studies, and next-generation bioimaging tools.
DOI: 10.15468/hdwrgq
title: coastal sediment Raw sequence reads

description: Diversity of Rhodopirellula and related planctomycetes. This study investigates the diversity of Rhodopirellula and related planctomycetes in an intertidal sediment of Sylt island, Germany, employing carB gene, coding for the large subunit of carbamoylphosphate synthetase, as a marker gene.