cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.17595/20230901.001
title: Global map of the dry deposition velocity of atmospheric hydrogen on the land surface

description: This dataset is a global map of the land surface dry deposition rate of atmospheric hydrogen calculated by the Japanese climate model MIROC. In this calculation, In MIROC, CHASER was used as the chemical model component, and MATSIRO was used as the land surface model component. Using the land surface conditions (soil moisture content, soil temperature, ground surface wind speed, etc.) calculated online, the hydrogen consumption intensity by enzymes in the soil and the vertical diffusion coefficient into the soil was calculated.
DOI: 10.17597/isas.darts/hyb2-01000
title: Hayabusa2 MASCOT MARA Radiometer Bundle

description: This PDS4 bundle collects all the operational data products produced by the Hayabusa2 MASCOT MARA Radiometer.
DOI: 10.6084/m9.figshare.21510511.v1
title: Additional file 12 of Methylome and transcriptome data integration reveals potential roles of DNA methylation and candidate biomarkers of cow Streptococcus uberis subclinical mastitis

description: Additional file 12: Table S7. Functional enrichment of genes harboring at least 15 DMCs.
DOI: 10.6084/m9.figshare.21510517
title: Additional file 14 of Methylome and transcriptome data integration reveals potential roles of DNA methylation and candidate biomarkers of cow Streptococcus uberis subclinical mastitis

description: Additional file 14: Table S9. The list of differentially expressed (DE) genes and their functional enrichment.
DOI: 10.6084/m9.figshare.21510520.v1
title: Additional file 15 of Methylome and transcriptome data integration reveals potential roles of DNA methylation and candidate biomarkers of cow Streptococcus uberis subclinical mastitis

description: Additional file 15: Table S10. The genome-wide correlation between DNA methylation and gene expression and list of MetGDE genes.
DOI: 10.25387/g3.6830633
title: Supplemental Material for Murgiano et al., 2018

description: File_S1: List and accession numbers of the 196 genomes of the studyFile_S2 – Primers used in the study. File_S3 – Orientation of the 45 bp interval copy File_S4 – Targeted sequencing results for the region. File_S5 – Detail of the markers situated within the repeated region.File_S6 The four transcripts detected by cloning and sequencing.File_S7 Alignment of the wild type and mutant predicted protein.
DOI: 10.25387/g3.6830633.v1
title: Supplemental Material for Murgiano et al., 2018

description: File_S1: List and accession numbers of the 196 genomes of the studyFile_S2 – Primers used in the study. File_S3 – Orientation of the 45 bp interval copy File_S4 – Targeted sequencing results for the region. File_S5 – Detail of the markers situated within the repeated region.File_S6 The four transcripts detected by cloning and sequencing.File_S7 Alignment of the wild type and mutant predicted protein.
DOI: 10.6084/m9.figshare.21510556
title: Additional file 9 of Methylome and transcriptome data integration reveals potential roles of DNA methylation and candidate biomarkers of cow Streptococcus uberis subclinical mastitis

description: Additional file 9: Table S4. The number of DMCs (CpG, CHG and CHH) in different genetic regions.
DOI: 10.6084/m9.figshare.21510526.v1
title: Additional file 17 of Methylome and transcriptome data integration reveals potential roles of DNA methylation and candidate biomarkers of cow Streptococcus uberis subclinical mastitis

description: Additional file 17: Table S12. The cluster of functional annotations enriched by differential methylated and expressed genes (MetGDE genes).
DOI: 10.6084/m9.figshare.21510547
title: Additional file 6 of Methylome and transcriptome data integration reveals potential roles of DNA methylation and candidate biomarkers of cow Streptococcus uberis subclinical mastitis

description: Additional file 6: Table S1. Genes and their primer sequences used for real-time qPCR validation of RNA-sequencing results.
DOI: 10.6084/m9.figshare.21510547.v1
title: Additional file 6 of Methylome and transcriptome data integration reveals potential roles of DNA methylation and candidate biomarkers of cow Streptococcus uberis subclinical mastitis

description: Additional file 6: Table S1. Genes and their primer sequences used for real-time qPCR validation of RNA-sequencing results.
DOI: 10.6084/m9.figshare.21510553
title: Additional file 8 of Methylome and transcriptome data integration reveals potential roles of DNA methylation and candidate biomarkers of cow Streptococcus uberis subclinical mastitis

description: Additional file 8: Table S3. The list of differentially methylated cytosines (DMCs) in the context of CpG, CHG and CHH.
DOI: 10.6084/m9.figshare.21510523.v1
title: Additional file 16 of Methylome and transcriptome data integration reveals potential roles of DNA methylation and candidate biomarkers of cow Streptococcus uberis subclinical mastitis

description: Additional file 16: Table S11. The results of functional enrichment differentially methylated and expressed genes (MetGDE genes).
DOI: 10.6084/m9.figshare.21510553.v1
title: Additional file 8 of Methylome and transcriptome data integration reveals potential roles of DNA methylation and candidate biomarkers of cow Streptococcus uberis subclinical mastitis

description: Additional file 8: Table S3. The list of differentially methylated cytosines (DMCs) in the context of CpG, CHG and CHH.
DOI: 10.6084/m9.figshare.21510556.v1
title: Additional file 9 of Methylome and transcriptome data integration reveals potential roles of DNA methylation and candidate biomarkers of cow Streptococcus uberis subclinical mastitis

description: Additional file 9: Table S4. The number of DMCs (CpG, CHG and CHH) in different genetic regions.
DOI: 10.6084/m9.figshare.14694948.v1
title: Association between AKT2 gene polymorphism and polycystic ovary syndrome: a case-control study

description: This study was conducted to understand the association between the AKT2 (AKT serine/threonine kinase 2) gene polymorphism (rs2304186) and PCOS. In total, 1287 participants were included. Six genotype models (Dominant model: TT + TG vs. GG; Recessive model: TT vs. TG + GG; Over-dominant model: TT + GG vs. TG; Co-dominant model: TT vs. TG; Co-dominant TT vs. GG; Allele analysis: T vs. G) were applied in the analysis. According to the races and obesity, subgroup analyses were also performed. No significant association between rs2304186 and PCOS was identified in the whole sample or the Han groups, even after multi-adjustments. Only in the Zhuang groups was it suggested that rs2304186 might promote the risk of PCOS to some extent (Unadjusted: Over-dominant TT + GG vs. TG, OR = 1.522, 95%CI = 1.076–2.152, <i>p</i> = .018; Age-adjusted: Over-dominant TT + GG vs. TG, OR = 1.543, 95%CI = 1.069–2.228, <i>p</i> = .021; Multi-adjusted: OR = 1.497, 95%CI = 1.024–2.188, <i>p</i> = .037). The risk effect was also detected in the non-obesity group (BMI &lt;24.0 kg/m<sup>2</sup>) for the Co-dominant model (TT vs. TG: OR = 1.355, 95%CI = 1.001–1.835, <i>p</i> = .050). In summary, we first discovered that rs2304186 might significantly elevate the PCOS risk, especially in the Chinese Zhuang population and the non-obesity group. Further studies are needed to confirm these results.
DOI: 10.6084/m9.figshare.21510520
title: Additional file 15 of Methylome and transcriptome data integration reveals potential roles of DNA methylation and candidate biomarkers of cow Streptococcus uberis subclinical mastitis

description: Additional file 15: Table S10. The genome-wide correlation between DNA methylation and gene expression and list of MetGDE genes.
DOI: 10.6084/m9.figshare.21510514.v1
title: Additional file 13 of Methylome and transcriptome data integration reveals potential roles of DNA methylation and candidate biomarkers of cow Streptococcus uberis subclinical mastitis

description: Additional file 13: Table S8. The list of differentially methylated haplotype blocks (dMHBs) and functional enrichment for hyper dMHBs.
DOI: 10.6084/m9.figshare.21510523
title: Additional file 16 of Methylome and transcriptome data integration reveals potential roles of DNA methylation and candidate biomarkers of cow Streptococcus uberis subclinical mastitis

description: Additional file 16: Table S11. The results of functional enrichment differentially methylated and expressed genes (MetGDE genes).
DOI: 10.6084/m9.figshare.23607927
title: Diagnosis for Chinese patients with light chain amyloidosis: a scoping review

description: Amyloid light chain (AL) amyloidosis is the most common systemic amyloidosis. The objective of this scoping review was to map the available literature on the diagnosis of AL amyloidosis in China. The published academic papers related to the diagnosis of AL amyloidosis were screened from 1 January 2000 to 15 September 2021. Chinese patients who have suspected AL amyloidosis were included. The included studies were categorized into accuracy studies and descriptive studies based on if the studies supplied the diagnostic accuracy data or not. The information on the diagnostic methods reported by included studies was synthesized. Forty-three articles were included for the final scoping review, with 31 belonging to descriptive studies and 12 having information on diagnostic accuracy. Although cardiac involvement was second top in Chinese patients with AL amyloidosis, a cardiac biopsy was rare. Next, we found light chain classification and monoclonal (M-) protein identification were essential methods for the diagnosis of AL amyloidosis in China. In addition, some combined tests (e.g. immunohistochemistry and serum free light chain, immunohistochemistry and immunofixation electrophoresis, and serum free light chain and immunofixation electrophoresis) can increase the sensitivity of the diagnosis. Finally, several adjuvant methods (e.g. Imaging, N-terminal-pro hormone BNP, and brain natriuretic peptide test) were important for AL amyloidosis diagnosis. This scoping review details the characteristics and results of the recently published studies on diagnosing AL Amyloidosis in China. Biopsy is the most important method for AL Amyloidosis diagnosis in China. In addition, combined tests and some adjuvant methods played essential roles in the diagnosis. Further research is required to determine an acceptable and feasible diagnostic algorithm after symptom onset. <b>REGISTRATION:</b> INPLASY2022100096KEY MESSAGESThis scoping review details the characteristics and results of the recently published studies on diagnosing Amyloid light chain (AL) Amyloidosis in China.Biopsy is the most important method for AL Amyloidosis diagnosis in China.Combined tests and some adjuvant methods played essential roles in the diagnosis. This scoping review details the characteristics and results of the recently published studies on diagnosing Amyloid light chain (AL) Amyloidosis in China. Biopsy is the most important method for AL Amyloidosis diagnosis in China. Combined tests and some adjuvant methods played essential roles in the diagnosis.
DOI: 10.6084/m9.figshare.23607927.v1
title: Diagnosis for Chinese patients with light chain amyloidosis: a scoping review

description: Amyloid light chain (AL) amyloidosis is the most common systemic amyloidosis. The objective of this scoping review was to map the available literature on the diagnosis of AL amyloidosis in China. The published academic papers related to the diagnosis of AL amyloidosis were screened from 1 January 2000 to 15 September 2021. Chinese patients who have suspected AL amyloidosis were included. The included studies were categorized into accuracy studies and descriptive studies based on if the studies supplied the diagnostic accuracy data or not. The information on the diagnostic methods reported by included studies was synthesized. Forty-three articles were included for the final scoping review, with 31 belonging to descriptive studies and 12 having information on diagnostic accuracy. Although cardiac involvement was second top in Chinese patients with AL amyloidosis, a cardiac biopsy was rare. Next, we found light chain classification and monoclonal (M-) protein identification were essential methods for the diagnosis of AL amyloidosis in China. In addition, some combined tests (e.g. immunohistochemistry and serum free light chain, immunohistochemistry and immunofixation electrophoresis, and serum free light chain and immunofixation electrophoresis) can increase the sensitivity of the diagnosis. Finally, several adjuvant methods (e.g. Imaging, N-terminal-pro hormone BNP, and brain natriuretic peptide test) were important for AL amyloidosis diagnosis. This scoping review details the characteristics and results of the recently published studies on diagnosing AL Amyloidosis in China. Biopsy is the most important method for AL Amyloidosis diagnosis in China. In addition, combined tests and some adjuvant methods played essential roles in the diagnosis. Further research is required to determine an acceptable and feasible diagnostic algorithm after symptom onset. <b>REGISTRATION:</b> INPLASY2022100096KEY MESSAGESThis scoping review details the characteristics and results of the recently published studies on diagnosing Amyloid light chain (AL) Amyloidosis in China.Biopsy is the most important method for AL Amyloidosis diagnosis in China.Combined tests and some adjuvant methods played essential roles in the diagnosis. This scoping review details the characteristics and results of the recently published studies on diagnosing Amyloid light chain (AL) Amyloidosis in China. Biopsy is the most important method for AL Amyloidosis diagnosis in China. Combined tests and some adjuvant methods played essential roles in the diagnosis.
DOI: 10.6084/m9.figshare.22559410
title: 3 factor Procrustes 1 from Majestic tigers: personality structure in the great Amur cat

description: Procrustes rotation testing 3-factor solution with raters in sample 1
DOI: 10.6084/m9.figshare.22559410.v1
title: 3 factor Procrustes 1 from Majestic tigers: personality structure in the great Amur cat

description: Procrustes rotation testing 3-factor solution with raters in sample 1
DOI: 10.6084/m9.figshare.22559419
title: Factor & trait correlation 1 from Majestic tigers: personality structure in the great Amur cat

description: Correlation between factors and traits in sample 2
DOI: 10.6084/m9.figshare.22559413
title: Dataset 1 from Majestic tigers: personality structure in the great Amur cat

description: Sample 1 dataset
DOI: 10.6084/m9.figshare.22559419.v1
title: Factor & trait correlation 1 from Majestic tigers: personality structure in the great Amur cat

description: Correlation between factors and traits in sample 2
DOI: 10.6084/m9.figshare.22559413.v1
title: Dataset 1 from Majestic tigers: personality structure in the great Amur cat

description: Sample 1 dataset
DOI: 10.6084/m9.figshare.22559422
title: EFA raters in 1 from Majestic tigers: personality structure in the great Amur cat

description: EFA with raters left in sample 1
DOI: 10.6084/m9.figshare.22559416
title: Dataset 2 from Majestic tigers: personality structure in the great Amur cat

description: Sample 2 dataset
DOI: 10.6084/m9.figshare.22559422.v1
title: EFA raters in 1 from Majestic tigers: personality structure in the great Amur cat

description: EFA with raters left in sample 1
DOI: 10.6084/m9.figshare.22559416.v1
title: Dataset 2 from Majestic tigers: personality structure in the great Amur cat

description: Sample 2 dataset
DOI: 10.6084/m9.figshare.22559425
title: Raters removed EFA from Majestic tigers: personality structure in the great Amur cat

description: EFA with Raters removed sample 1
DOI: 10.6084/m9.figshare.22559425.v1
title: Raters removed EFA from Majestic tigers: personality structure in the great Amur cat

description: EFA with Raters removed sample 1
DOI: 10.6084/m9.figshare.22559428
title: PCA 1 no raters from Majestic tigers: personality structure in the great Amur cat

description: PCA sample 1 with raters removed
DOI: 10.6084/m9.figshare.22559428.v1
title: PCA 1 no raters from Majestic tigers: personality structure in the great Amur cat

description: PCA sample 1 with raters removed
DOI: 10.6084/m9.figshare.7355105
title: Mass Spectrometry MSMS and HDX Raw File Data

description: In support of the publication "Irisin Mediates Effects on Bone and Fat via V Integrin Receptors", the mass spectrometry raw files for the hydrogen deuterium exchange (HDX) experiments have been made available. In addition the MSMS related files have been provided in the form of the proteome discoverer result and study file, the peptide spectra match data export, and the raw MSMS file in the MSMS.zip file. Also included is a screenshot of the Proteome Discoverer results, HDX sequence coverage heat maps, deuterium uptake curves and single amide resolution heat maps from consolidation of the overlapping HDX peptides. A high level figure outlining the consolidation approach is available as well.
DOI: 10.6084/m9.figshare.7879415
title: Deficiency of mitophagy receptor FUNDC1 impairs mitochondrial quality and aggravates dietary-induced obesity and metabolic syndrome

description: There is overwhelming evidence for an association between impaired mitochondrial function and metabolic syndrome. Mitophagy, a process that selectively removes damaged mitochondria <i>via</i> a specialized form of autophagy, is essential for mitochondrial quality control (mitochondrial QC) and metabolic homeostasis. We thus addressed the potential role of defective mitophagy in the pathogenesis of metabolic disorders. Mice lacking <i>Fundc1</i>, a newly characterized mitophagy receptor, develop more severe obesity and insulin resistance when fed a high-fat diet (HFD). Ablation of <i>Fundc1</i> results in defective mitophagy and impaired mitochondrial QC <i>in vitro</i> and in white adipose tissue (WAT). In addition, there is more pronounced WAT remodeling with more adipose tissue-associated macrophages infiltration, more M1 macrophage polarization and thus an elevated inflammatory response. Mechanistically, hyperactivation of MAPK/JNK leads to insulin insensitivity, which can be inhibited by knocking out <i>Mapk8</i>/<i>Jnk1</i> in <i>fundc1</i> KO mice. Our results demonstrate that dysregulated mitochondrial QC due to defective mitophagy receptor FUNDC1 links with metabolic disorders <i>via</i> MAPK signaling and inflammatory responses. <b>Abbreviations</b>: ATMs: adipose tissue macrophages; BAT: brown adipose tissue; BMDMs: bone marrow-derived macrophages; GOT1/AST: glutamic-oxaloacetic transaminase 1, soluble; GPT/ALT: glutamic pyruvic transaminase, soluble; H&E staining: hematoxylin and eosin staining; HFD: high-fat diet; LIR: LC3-interacting region; mitochondrial QC: mitochondrial quality control; mito-ROS: mitochondrial ROS; mtDNA: mitochondrial DNA; RT-PCR: real-time-PCR; T2D: type 2 diabetes; WAT: white adipose tissue
DOI: 10.6084/m9.figshare.7879415.v2
title: Deficiency of mitophagy receptor FUNDC1 impairs mitochondrial quality and aggravates dietary-induced obesity and metabolic syndrome

description: There is overwhelming evidence for an association between impaired mitochondrial function and metabolic syndrome. Mitophagy, a process that selectively removes damaged mitochondria <i>via</i> a specialized form of autophagy, is essential for mitochondrial quality control (mitochondrial QC) and metabolic homeostasis. We thus addressed the potential role of defective mitophagy in the pathogenesis of metabolic disorders. Mice lacking <i>Fundc1</i>, a newly characterized mitophagy receptor, develop more severe obesity and insulin resistance when fed a high-fat diet (HFD). Ablation of <i>Fundc1</i> results in defective mitophagy and impaired mitochondrial QC <i>in vitro</i> and in white adipose tissue (WAT). In addition, there is more pronounced WAT remodeling with more adipose tissue-associated macrophages infiltration, more M1 macrophage polarization and thus an elevated inflammatory response. Mechanistically, hyperactivation of MAPK/JNK leads to insulin insensitivity, which can be inhibited by knocking out <i>Mapk8</i>/<i>Jnk1</i> in <i>fundc1</i> KO mice. Our results demonstrate that dysregulated mitochondrial QC due to defective mitophagy receptor FUNDC1 links with metabolic disorders <i>via</i> MAPK signaling and inflammatory responses. <b>Abbreviations</b>: ATMs: adipose tissue macrophages; BAT: brown adipose tissue; BMDMs: bone marrow-derived macrophages; GOT1/AST: glutamic-oxaloacetic transaminase 1, soluble; GPT/ALT: glutamic pyruvic transaminase, soluble; H&E staining: hematoxylin and eosin staining; HFD: high-fat diet; LIR: LC3-interacting region; mitochondrial QC: mitochondrial quality control; mito-ROS: mitochondrial ROS; mtDNA: mitochondrial DNA; RT-PCR: real-time-PCR; T2D: type 2 diabetes; WAT: white adipose tissue
DOI: 10.6084/m9.figshare.7879415.v1
title: Deficiency of Mitophagy Receptor FUNDC1 Impairs Mitochondrial Quality and Aggravates Dietary-Induced Obesity and Metabolic Syndrome

description: There is overwhelming evidence for an association between impaired mitochondrial function and metabolic syndrome. Mitophagy, a process that selectively removes damaged mitochondria <i>via</i> a specialized form of autophagy, is essential for mitochondrial quality control (mitochondrial QC) and metabolic homeostasis. We thus addressed the potential role of defective mitophagy in the pathogenesis of metabolic disorders. Mice lacking <i>Fundc1</i>, a newly characterized mitophagy receptor, develop more severe obesity and insulin resistance when fed a high-fat diet (HFD). Ablation of <i>Fundc1</i> results in defective mitophagy and impaired mitochondrial QC <i>in vitro</i> and in white adipose tissue (WAT). In addition, there is more pronounced WAT remodeling with more adipose tissue-associated macrophages infiltration, more M1 macrophage polarization and thus an elevated inflammatory response. Mechanistically, hyperactivation of MAPK/JNK leads to insulin insensitivity, which can be inhibited by knocking out <i>Mapk8</i>/<i>Jnk1</i> in <i>fundc1</i> KO mice. Our results demonstrate that dysregulated mitochondrial QC due to defective mitophagy receptor FUNDC1 links with metabolic disorders <i>via</i> MAPK signaling and inflammatory responses.
DOI: 10.6084/m9.figshare.22559526
title: Choline and trimethylamine N-oxide supplementation in normal chow diet and western diet promotes the development of atherosclerosis in Apoe –/– mice through different mechanisms

description: Trimethylamine N-oxide (TMAO), a gut microbiota-dependent metabolite, has been shown to aggravate cardiovascular disease. However, the mechanisms of TMAO in the setting of cardiovascular disease progress remain unclear. Here, we aim to investigate the effects of TMAO on atherosclerosis (AS) development and the underlying mechanisms. Apoe –/– mice received choline or TMAO supplementation in a normal diet and a western diet for 12 weeks. Choline or TMAO supplementation in both normal diet and western diet significantly promoted plaque progression in Apoe–/– mice. Besides, serum lipids levels and inflammation response in the aortic root were enhanced by choline or TMAO supplementation. In particular, choline or TMAO supplementation in the western diet changed intestinal microbiota composition and bile acid metabolism. Therefore, choline or TMAO supplementation may promote AS by modulating gut microbiota in mice fed with a western diet and by other mechanisms in mice given a normal diet, even choline or TMAO supplementation in a normal diet can promote AS.
DOI: 10.6084/m9.figshare.20462211
title: Additional file 3 of Small-area estimation for public health surveillance using electronic health record data: reducing the impact of underrepresentation

description: Additional file 3. Predictions from each model (M0, M1, M2) for each test condition (asthma, diabetes, hypertension, obesity, smoking) for each practice (Atrius, CHA, MLCHC, aggregate) in each of the 351 municipalities.