cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.7246628.v1
title: Supplementary Material for: Predictors and Management of Antiplatelet-Related Bleeding Complications for Acute Coronary Syndrome in Chinese Elderly Patients

description: <b><i>Background/Aims:</i></b> Bleeding complications after percutaneous coronary intervention (PCI) are strongly associated with adverse patient outcomes. However, there are no specific guidelines for the predictors and management of antiplatelet-related bleeding complications in Chinese elderly patients with acute coronary syndrome (ACS). <b><i>Methods:</i></b> A retrospective analysis of 237 consecutive patients (aged ≥ 75 years) with ACS who had undergone successful PCI from January 2010 to December 2016 was performed to identify predictors and management of antiplatelet-related bleeding complications. Multivariate logistic regression analysis was conducted to investigate independent predictors of antiplatelet-related bleeding complications. We defined antiplatelet-related bleeding complications as first hospitalization received long-term oral antiplatelet therapy and required hospitalization, including gastrointestinal and intracranial bleedings. <b><i>Results:</i></b> After multivariable adjustment, independent risk predictors of antiplatelet-related bleeding complications included female gender (odds ratio [OR]: 2.96; 95% confidence interval [CI]: 1.98 to 4.15; <i>P</i> = 0.011), body mass index (OR: 1.54; 95% CI: 1.06 to 1.94; <i>P</i> = 0.034), previous history of bleeding (OR: 4.03; 95% CI: 1.84 to 6.12; <i>P</i> = 0.004), fasting blood glucose (OR: 2.79; 95% CI: 1.23 to 4.46; <i>P</i> = 0.025), and chronic total occlusion lesion (OR: 4.69; 95% CI: 2.19 to 7.93; <i>P</i> = 0.007). Of 46 patients with antiplatelet-related bleeding complications, 54.3% were treated short-term dual antiplatelet therapy (DAPT) cessation (0–7 days) and 45.7% underwent long-term DAPT cessation (&gt; 7 days). Among these, 14 patients presented major adverse cardiac and cerebrovascular events (MACCE), whereas no re-bleeding happened over all available follow-up. The incidence of MACCE was not significantly different between the two groups one year after PCI (36.0% for short-term DAPT cessation versus 23.8% for long-term DAPT cessation, <i>P</i> = 0.522). <b><i>Conclusion:</i></b> For elderly patients with ACS, multiple factors were likely to contribute to antiplatelet-related bleeding complications, especially previous history of bleeding and chronic total occlusion lesion. Better individualized, tailored and risk-adjusted antiplatelet therapy after PCI is urgently needed in this high-risk population.
DOI: 10.6084/m9.figshare.22298230.v1
title: Table 6. Results from multiple regression analysis

description: <em><strong>Table 6. Results from multiple regression analysis</strong></em>
DOI: 10.6084/m9.figshare.22756943.v1
title: Atmospheric modes fiddling the simulated ENSO impact on tropical cyclone genesis over the Northwest Pacific

description: The data used in this study.
DOI: 10.6084/m9.figshare.5808741.v1
title: Historical Population Models

description: This compressed file contains models developed through ArcGIS Model Builder for reconstructing USA historical population maps, including five models (M1-M5), and the determination of census tract cutoff population, s and d parameter values.
DOI: 10.6084/m9.figshare.7501001.v1
title: curated_trait_data.csv

description: Trait data mined from literature and online data repositories. Trait data derived from the sources listed in Table 1 with Latin binomials that matched either those from the SILVA-based taxonomic identifications of OTUs found in infant gut microbiome samples, or from type specimens in the 132 release of the Living Tree Project. When observations existed for the same taxon across more than one data source, means were used.
DOI: 10.11583/dtu.22182694.v1
title: HPLC-DAD chromatrograms of oxidized oceanic DOM used for lignin phenol analysis

description: The dataset is part of a paper in Limnology & Oceanography: Methods with the following title: "Lignin phenol quantification from machine learning-assisted decomposition of liquid chromatography-absorbance spectroscopy data" https://doi.org/10.1002/lom3.10561 The dataset contains HPLC-DAD chromatograms and metadata of the samples. The dataset is designed to run with our novel 2nd derivative/PARAFAC2 algorithm created for the decomposition of HPLC-DAD chromtograms for quantification of lignin phenols. The algorithm (matlab code) can be found using this DOI: https://doi.org/10.11583/DTU.22178825 However, the dataset may also be used for other interest.
DOI: 10.6084/m9.figshare.4254578.v1
title: MYOP: cross-validation dataset

description: This dataset was used to evaluate MYOP using 5 fold cross-validation.
DOI: 10.17632/d4f6jmkpsw
title: IN2SIGHT_MAN_UNIMIB_WP{1,5,7}_Management_Plans_20220223

description: This folder contains documents related to the regulatory plan (folder: Regulatory plan, D.5.1), to the Risk managament plan (folder: Risk Management, D1.1) and to the data management plan (folder: data management plan, D7.1). Update from Version 3 is the addition of the Annex 1 to the DMP that contains the indications for the data storage of digital pathology data.
DOI: 10.6084/m9.figshare.12413444.v1
title: Data for 'Magnetotail-Inner Magnetosphere Transport Associated With Fast Flows Based on Combined Global-Hybrid and CIMI Simulation.'

description: The numerical data used for 'Magnetotail-Inner Magnetosphere Transport Associated With Fast Flows Based on Combined Global-Hybrid and CIMI Simulation.'
DOI: 10.6084/m9.figshare.17122217.v1
title: Data Goldfish Hypoxia

description: These data are used in Thoral et al paper, published in JEB, dealing with hypoxia acclimation and muscle bioenergetics in goldfish.<br><br>
DOI: 10.6084/m9.figshare.21780674.v7
title: Experimental Data: Potency Development of Seagrass (Syringodium isoetifolium) as Food Bioactive Constituents by Different Extraction Techniques

description: Underlying data for the research results of yield, total phenolic, bioactive compounds, cytotoxicity, and in-silico on Seagrass extract
DOI: 10.6084/m9.figshare.28049885.v1
title: Hyacinthus orientalis raw GC-MS files

description: Metabolite extraction from Hyacinthus orientalis leaf tissue
DOI: 10.6084/m9.figshare.28368746.v2
title: Supplemental material: <b>Evidence for HCO</b><sub><strong>3</strong></sub><sup><strong>-</strong></sup><b> and NH</b><sub><strong>3</strong></sub><b>/NH</b><sub><strong>4</strong></sub><sup><strong>+</strong></sup><b> dependent pH regulatory mechanisms in the alkaline midgut of the sea urchin larva</b>

description: This file contains supplemental material to the manuscript entitled: Evidence for HCO<sub>3</sub><sup>-</sup> and NH<sub>3</sub>/NH<sub>4</sub><sup>+</sup> dependent pH regulatory mechanisms in the alkaline midgut of the sea urchin larvaThis supplemental material contains additional methodology, two tables (Table S1-S2) as well as supplemental figures S1-S6.
DOI: 10.6084/m9.figshare.14483637.v1
title: Supplementary Material for: Cell-Free Circulating Tumor DNA Improves Standard Genotyping of Non-Small-Cell Lung Cancer and Increases Detection of Targetable Alterations in a Selected Hispanic Cohort

description: <b><i>Background:</i></b> Several studies have shown that the non-small-cell lung cancer (NSCLC) genomic background among Hispanics differs from other populations. The finding of low-frequency genomic alterations in cell-free DNA (cfDNA) can increase diagnostic accuracy and could improve treatment in NSCLC. <b><i>Methods:</i></b> Data from 54 Hispanic patients with advanced NSCLC with high clinical suspicion for <i>ALK</i>, <i>EGFR</i>, and <i>ROS1</i> mutations were collected (including young age, female sex, and non-smokers). cfDNA was extracted from plasma and analyzed using a commercial next-generation sequencing test (Guardant360) which detects genomic alterations in 74 genes. <b><i>Results:</i></b> The median age was 56 years (range 31–83). Most patients were female (661.1%) and never smokers (72.3%). Among the patients included, 96% (52/54) had cfDNA detectable alterations with a mean number of 3.37 cfDNA alterations per test (range 1–10). cfDNA was able to detect some genomic alterations previously undetected by tissue biopsy. Among patients with insufficient or unavailable tissue to perform testing, mutations in <i>EGFR</i> and <i>ALK</i> which led to a change in therapy were determined using cfDNA in 28.8 and 3.8% of cases, respectively. Among patients with cfDNA alterations, 46.1% (<i>n</i> = 24) were switched to a targeted therapy with a median progression-free survival of 11.1 months (95% CI 7.6–14.6) and an overall survival of 40.3 months (95% CI 27.1–53.6). Concurrent genetic mutations with <i>TP53</i> and <i>KRAS</i> negatively impacted the prognosis. <b><i>Conclusions:</i></b> In a selected population of NSCLC Hispanic patients, comprehensive cfDNA analysis allowed a treatment change in 46.1% of the cases. Guardant360 allows the identification of genomic alterations to improve treatment selection and increase prognosis.
DOI: 10.17632/zb9gcvtm8f
title: Effect of subtitle on gaze behaviour during shot changes in cinema

description: To study the presence or absence of subtitles in cinema influences the gaze behavior of viewers.
DOI: 10.6084/m9.figshare.8976473.v1
title: On the discovery of population-specific state transitions from single-cell RNA sequencing data

description: 10x genomics single cell data -- 8 mice, treated either with vehicle or LPS (4 replicates each). Brain cortex tissue. See the enclosed metadata.xlsx files. Enclosed are the output files (barcodes.tsv, genes.tsv, matrix.mtx) needed for preprocessing and analysis in the R scripts from <br>https://github.com/HelenaLC/muscat-comparison/tree/master/LPS
DOI: 10.17632/f5jtt3s8hv
title: GCN2 is a determinant of the response to WEE1 kinase inhibition in small-cell lung cancer

description: Patients with small-cell lung cancer (SCLC) are in dire need of more effective therapeutic options. Frequent disruption of the G1 checkpoint in SCLC cells creates a dependency on the G2/M checkpoint to maintain genomic integrity. Indeed, in pre-clinical models, inhibiting the G2/M checkpoint kinase WEE1 shows promise in inhibiting SCLC growth. However, toxicity and acquired resistance have limited the clinical effectiveness of this strategy. Here, using CRISPR/Cas9 knockout screens in vitro and in vivo, we identified multiple factors influencing the response of SCLC cells to the WEE1 kinase inhibitor AZD1775, including the GCN2 kinase and other members of its signaling pathway. Rapid activation of GCN2 upon AZD1775 treatment triggers a stress response in SCLC cells. Pharmacological or genetic activation of the GCN2 pathway enhances cancer cell killing by AZD1775. Thus, activation of the GCN2 pathway represents a novel approach for augmenting the efficacy of WEE1 inhibitors in SCLC.
DOI: 10.17632/sfbpt6sjb3
title: FTIR spectra of 1 μm thick pure amorphous, α, β and γ polyvinyledene fluoride (PVDF) phases at 160 ◦C

description: This dataset contains FTIR absorbance spectra (normalised to 1 μm sample thickness) for pure amorphous, α, β and γ PVDF phases at 160 ◦C.  These spectra can be used for accurate measurement of amorphous, α, β and γ phases in a PVDF sample spectra with unknown composition.
DOI: 10.6084/m9.figshare.11877777.v3
title: Ecological_data_of_spiders_communities_present_in_native_forest_and_pine_plantations.

description: we present two data set about 259 species of spiders from the semideciduous Atlantic Forest of Argentina. The trait data set compiled information of morphological and ecological traits such as body size, femur length, ocular distance, foraging strategy, prey range, circadian activity and stratum preference.
DOI: 10.6084/m9.figshare.1289214.v3
title: SwissParam CHARMM Parameters files for the cancer drugs Cytarabine, Daunorubicin, Doxorubicin, and Vincristine

description: The SwissParam CHARMM parameters used in the study for the anti-cancer drugs Cytarabine, Daunorubicin, Doxorubicin, and Vincristine are provided here in zip file. Zip files can be opened by double-click the ZIP file in any operating systems.
DOI: 10.6084/m9.figshare.19716124.v1
title: CBAM data

description: CBAM data
DOI: 10.17632/9m6thb35p9
title: Spatiotemporal forecasting of the water change trends in Urmia Lake through 2030

description: The dataset contains the TM and ETM images of the Urmia Lake, located in the northwest of Iran. Additionally, the Space-time cubes, Forecast results, and results of the Emerging hot spot analysis are provided.
DOI: 10.6084/m9.figshare.6067997.v1
title: Histologically-derived atlas, right hemisphere (NIfTI format)

description: Histological segmentation of 108 structures for the right hemisphere from Chakravarty et al., (2006)
DOI: 10.6084/m9.figshare.11993574.v1
title: Supplementary Material for: Impact of Vascular Endothelial Growth Factor Gene Polymorphisms and Their Interactions with Environmental Factors on Susceptibility to Renal Cell Carcinoma

description: <b><i>Aims:</i></b> This study aimed to investigate the association of single nucleotide polymorphisms (SNPs) within vascular endothelial growth factor (<i>VEGF</i>) gene and additional gene-environment interaction with renal cell carcinoma (RCC) risk. <b><i>Methods:</i></b> PCR-restriction fragment length polymorphism was performed to detect SNPs. Hardy-Weinberg equilibrium and allele frequencies in cases and controls were calculated using SNPStats (http://bioinfo.iconcologia.net/SNPstats). Generalized multifactor dimensionality reduction (GMDR) was used to screen the best interaction combination among 4 SNPs, smoking, and alcohol drinking. Logistic regression was performed to investigate the association between 4 SNPs within <i>VEGF</i> gene, additional gene-smoking interaction, and RCC risk. <b><i>Results:</i></b> RCC risk was significantly higher in carriers with the T allele of rs833061 within <i>VEGF</i> gene than those with CC genotype (CT+TT vs. CC) {adjusted odds ratio (OR) (95% confidence interval [CI]) = 1.71 (1.17–2.32), <i>p</i> = 0.002} and higher in carriers with the A allele of rs699947 within <i>VEGF</i> gene than those with GG genotype (GA+AA vs. GG) (adjusted OR [95% CI] = 1.64 [1.27–2.10], <i>p</i> &lt; 0.001). GMDR analysis indicated a significant 2-locus model (<i>p</i> = 0.0010) involving rs833061 and smoking. The cross-validation consistency of the 2-locus model was 10/10, and the testing accuracy was 60.72%. Current smokers with rs833061-CT+TT genotype had the highest RCC risk, compared to never smokers with rs833061-CC genotype within <i>VEGF</i> gene (OR [95% CI] = 3.02 [1.84–4.23], <i>p</i> &lt; 0.001). <b><i>Conclusions:</i></b> We found that the T allele of rs833061 and the A allele of rs699947 within <i>VEGF</i> gene, and the interaction between rs833061 and smoking were all associated with increased RCC risk.
DOI: 10.6084/m9.figshare.25187756.v1
title: Code and selected data for article "Choosing blocks for spatial cross-validation: Lessons from a marine remote sensing case study"

description: Code and selected data for testing how much block size, shape, number of folds, and other factors affect error estimates from spatial block cross-validation. Supplement to the article: Stock, A. (2925). Choosing blocks for spatial cross-validation: Lessons from a marine remote sensing case study. Frontiers in Remote Sensing, DOI: 10.3389/frsen.2025.1531097.
DOI: 10.6084/m9.figshare.20695510.v1
title: octopus_bimaculoides_decontaminated_FSCR.fasta.gz

description: .........
DOI: 10.6084/m9.figshare.26831812.v1
title: All_participants.csv

description: Data set that is used to perform the statistical analysis
DOI: 10.17632/43br98f865
title: Data on Estimation of Health Hazards Associated with Pesticide Residues in Drinking Water

description: raw dataset for "Data on Estimation of Health Hazards Associated with Pesticide Residues in Drinking Water"
DOI: 10.25415/ujhb.24533395.v1
title: Young professionals' retirement planning knowledge, attitude and behaviour

description: The study investigated young professionals' retirement planning knowledge, attitude, and behaviour, which may inform a tertiary retirement planning educational programme. In addition, an investigation was conducted to determine whether South African tertiary institutions are equipping young professionals with retirement planning knowledge. A non-probabilistic, convenience sampling, quantitative survey research methodology was used to collect the data. Participants included young professionals with tertiary qualifications from different disciplines.The data-set includes the raw data as well as the organised data.
DOI: 10.6084/m9.figshare.7000751.v1
title: Supplementary Material for: Targeting Peroxisome Proliferator Activated Receptor α (PPAR α) for the Prevention of Mitochondrial Impairment and Hypertrophy in Cardiomyocytes

description: <b><i>Background/Aims:</i></b> Morphological and biochemical maladaptation of cardiomyocytes are associated with mitochondrial dysfunction and dysregulation in hypertrophic conditions. Peroxisome proliferator activated receptor α (PPARα), a drug target for dyslipidemia, is known to be downregulated in cardiomyocytes in response to hypertrophic stimuli. The current study was undertaken to investigate the role of PPARα signaling in mitochondrial remodeling and thereby dysregulation of cardiomyocytes due to hypertrophy <i>in vitro</i>. <b><i>Methods:</i></b> Rat cardiomyocytes H9c2 (2-1) and neonatal rat ventricular myocytes (NRVMs) were cultured and treated with α<sub>1</sub>-adrenergic agonist phenylephrine (PE, 100 µM, 24 hours) in the presence or absence of 10 µM fenofibrate or bezafibrate. Cellular hypertrophy was observed by atomic force microscopy and immunofluorescence with F-actin antibody. mRNA levels of hypertrophic marker genes and other genes were examined by quantitative real time PCR. Structural as well as functional remodeling of the mitochondria were evaluated by immunofluorescence (F-actin and COX-I), live cell imaging microscopy (JC-I, mitotracker), mitochondrial complex V activity, MPTP activity and ATP assay. Oxidative stress was measured by using sensitive fluorescent indicator probes. Cellular and mitochondrial calcium were measured by using fluorescent indicator probes Rhod-2 AM and X-rhod-1 AM, respectively. Targetscan prediction analysis was performed to find out miRNAs as putative regulators of VDAC. Luciferase assay was conducted to confirm binding of miR28 with VDAC. <b><i>Results:</i></b> Co-treatment of H9c2(2-1) cells with PE and fenofibrate restricted increase in cell size and expression of marker genes such as atrial-natriuretic peptide (ANP), brain-natriuretic peptide (BNP) and β-myosin heavy chain (β-MHC) compared to those with PE alone. Fenofibrate prevented PE-induced down regulation of PPARα-target genes like CPT-I and MCAD. Mitochondrial trans-membrane potential (Δψ<sub>m</sub>) and motility were reduced by PE which were significantly checked by fenofibrate. Increased ROS production and calcium level in PE-treated cells were ameliorated by fenofibrate. Mitochondrial activity and ATP generation were reduced by PE which was rescued by fenofibrate. Fenofibrate also prevented PE-induced down regulation of mitochondrial genes like VDAC-I and COX-IV. Expression of several miRNAs was altered in hypertrophic cardiomyocytes which were restored when co-treated with fenofibrate. miR28 was found to target 3’ untranslated region of VDAC-I. <b><i>Conclusion:</i></b> Overall, the results demonstrate that PPARα signaling is critically involved in mitochondrial dysfunction in hypertrophic cardiomyocytes in which miR28 plays a pivotal role.
DOI: 10.6084/m9.figshare.13026560.v1
title: visual_textual_features_file

description: Download visual and textual features files to generate training and testing datasets.
DOI: 10.6084/m9.figshare.14528679.v2
title: Genome of the sea anemone Exaiptasia pallida and transcriptome profiles during tentacle regeneration

description: Annotation files of Genome of the sea anemone Exaiptasia pallida. <br> Reference: SHUM, C., et al. Genome of the sea anemone Exaiptasia pallida and transcriptome profiles during tentacle regeneration. <em>Frontiers in cell and developmental biology</em>, 2022, 10.
DOI: 10.6084/m9.figshare.15106020.v1
title: dataset inputs, outputs and force field validation data

description: The excel file contains: 1) the outputs of the AA simulations for DGEBA+PACM and DGEBA+D400 networks at varying DC, with two independent replicas for each system;2) the sets of input parameters of the non-bonded force field used to train the Gaussian Processes for the DGEBA+PACM and DGEBA+D400 systems;3) the outputs of the training CG simulations with a non-bonded force field based on the set of inputs mentioned at (2), with two independent replicas for each system;4) the numerical values of the force field parameters for the final simplified calibration (see Table 2 and Figure 4) at varying DC; 5) the outputs of the validation CG simulations with the final force field (see black stars in Figure5).
DOI: 10.6084/m9.figshare.25860424.v3
title: Sequence alignments related to Zabin et al. (2024) and also including alignments of the four loci without adjustments to some of the sequences.

description: Alignment .nex files of the ITS and multigene (ITS, LSU, TEF1 and RPB1) datasets used as a basis for phylogenetic reconstructions in Zabin et al. (2024) - Taxonomic reinvestigation of Favolus in the Neotropics utilizing morphological and multigene phylogenetic analyses
DOI: 10.6084/m9.figshare.4906874.v1
title: RNA-seq raw data of MS-N_1_1

description: File 1 of
RNA-seq raw data of N48-2 biological replicate 1 spikelets at mononuclear
stage. Paired-end sequencing strategy was applied on the Illumina HiSeq 4000
sequencing platform.
DOI: 10.17632/w55pxcvjg7
title: Awe of Intangible Cultural Heritage: The Perspective of ICH Tourists

description: This dataset was supplied for the study of Awe of Intangible Cultural Heritage: The Perspective of ICH Tourists, which
DOI: 10.6084/m9.figshare.21604752.v2
title: Qualitative DATA NVivo

description: Qualitative data from futsal coaches interviews
DOI: 10.6084/m9.figshare.14376137.v1
title: Mylopharyngodon_piceus_genome_cds

description: Black carp (Mylopharyngodon piceus, family Cyprinidae) is among the Four Domesticated Fishes in China, which has been cultured more than one thousand years and is characterized with its fast growth and delicious taste. The Black Carp, native to eastern Asia, is a large (&gt;1.5 m long), commercially important fish. To date, previous studies on the black carp have mainly focused on the fields of artificial culture, nutrition and feed, and disease prevention and control . Although some findings on the black carp transcriptome analysis are contained , there is a lack of basic genomics research data.