cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.15151/esrf-es-1404342584
title: Synthesis of FeS2 and NiS2 - part 2

description: A continuation of the proposal number CH6699, wherein the oxygen substitution of the synthesized FeS2 2D materials will be attempted in the INS2. If successful, we expect to grow 2D FeOS which will potentially have very interested magnetic and ferro-electric properties. H2S will be used to prepare the initial Fe sulfide 2D sheets using the methods tested during proposal CH6699 followed by a short oxidation step in the vacuum. X-ray beam will be used to carry out GIXRD characterizations (measurement of the CTRs, HK maps etc.). AES and RHEED will be used for supplementary characterization necessary for atomic structure determination.
DOI: 10.15151/esrf-es-1351929516
title: Operando pair distribution function measurements of silicon anodes

description: Silicon has approximately 10 times the capacity of the state-of-the-art anode material for lithium ion batteries (LIBs). To fully utilise the charge capacity of Si, it is crucial to understand why it loses capacity so quickly when the battery is put through cycles of charge and discharge, and why nanosizing of the Si is effective in extending its cycle life. The best way to gain information about the structural changes during cycling which cause deactivation is by an operando study in a working battery. We aim use total X-ray scattering to obtain the pair distribution functions (PDFs) of working nano-Si anodes. Previous studies of crystalline Si have given some insight in the structural mechanics of cycling, but do not give clean enough data. To mitigate this, we have developed a new operando battery cell. This will then give information about the structural changes of Si combined with electrochemical data.
DOI: 10.15151/esrf-es-1351929595
title: Correlative fluorescence and X-ray fluorescence chemical imaging of single cancer cells treated by gold-based anticancer drug candidates

description: Many gold(III) compounds have been reported to display cytotoxic properties and, as such, could provide safer alternatives to clinically approved platinum-based drugs used in cancer chemotherapy. So as to establish a clear rationale regarding the relationship between chemical structure and reactivity and biological properties, we intend to study the uptake and possible biotransformation of structurally related gold compounds in cancer cell models on the basis of chemical imaging by X-ray fluorescence microscopy to determine the spatial distribution of gold and endogenous elements in single cells at the nanometric scale. Correlative chemical and organelle fluorescence imaging will provide invaluable information on the possible tropism of the compounds to particular cellular compartments as well as their metabolism, giving clues to their mechanism of action.
DOI: 10.15151/esrf-es-1363680927
title: Localization of fibrillar polymorphs in human brain tissue

description: The proposed work will apply x-ray scanning micro-diffraction (µXRD) and x-ray micro fluorescence imaging (µXRF) to histological sections of human brain tissue to map the distribution of fibrillar aggregates of these proteins and the correlated abnormal deposition of specific elements in or around plaques and tangles. We have performed µXRD and µXRF on a section of hippocampus of a subject diagnosed with Alzheimer’s disease. These data have provided significant information on the distribution of fibrillar polymorphs among different plaques and tangles. Due to limited beamtime and initial issues with tissue flatness, we have not yet been able to measure tissue sections from all relevant brain regions for subjects with a full range of disease stages. Thus, to complete our characterization of the pathological pathway of Tau pathology, we propose to measure six brain regions from three patients at different stages of disease by µXRD at ID13 and µXRF at ID21.
DOI: 10.15151/esrf-es-1351189857
title: Time-resolved lattice dynamics of magnetic kagome metal Fe3Sn2

description: We propose the room-temperature, ultrafast XRD experiment on the magnetic kagome metal, Fe3Sn2, to study its structural changes upon optical pumping. This compound is a magnetic Weyl semimetal that combines topologically non-trivial band structures and flat-band ferromagnetism, both arising from the underlying kagome network of the Fe atoms. Our previous optical pump-probe transient reflectivity investigations suggested a unique interplay between phonons and the electronic structure in this compound. Here, we seek to understand the underlying structural changes that govern ultrafast dynamics of Fe3Sn2.
DOI: 10.15151/esrf-es-1351192327
title: Probing the Structural and Electronic Properties of Thin Film Energy Materials Under Highly-Controlled and Extreme Strain Conditions

description: Introducing lattice strain in functional materials is an unconventional strategy to boost their energy efficiency and performance beyond classic limits. Our ‘lab-on-chip’ approach consists of a single wafer device in which thousands of identical films are present under different strain conditions, in contrast to state-of-the-art approaches where only single strain levels are achieved. Here, the aim is to apply spatially resolved XAS to chart the structural and electronic property evolution across a broad and quasi-continuous range of strain conditions applied by the lab-on-chip device. By applying this approach for metal and metal halide perovskite thin films, unparalleled laws will be established between (i) the applied strain and (ii) the structure and electronic material properties, ultimately enabling one-to-one links to their performance.
DOI: 10.15151/esrf-es-1352322226
title: Temperature dependent structural phase transitions of the triangular lattice compound AgCrSe2, a frustrated metallic magnet

description: The triangular lattice compound AgCrSe2 shows exciting and unusual magnetic and transport properties that are up to now only partially understood, in particular it's recently observed anomalous Hall effect. The system is a non-collinear antiferromagnet with TN~32K. But despite sizeable spin-orbit coupling due to the magnetic exchange via Se, the observed anomalous Hall conductivity should be symmetry forbidden in the published R3m crystal structure (no inversion symmetry). However, the physical properties, in particular the transport, are strongly dependent on the exact composition of the compound. We suggest an investigation of the crystal structure of samples with well characterised composition (stoichiometric vs. Ag-poor) down to temperatures below TN and above T~450K (transition to R-3m with restored inversion symmetry). A composition dependent additional symmetry breaking in analogy to the Ag(Cu)CrS2 sister compounds could explain the observed spectacular physical properties.
DOI: 10.25388/nwu.24635151.v1
title: Heated Two-Tank System Data - Original System

description: The experimental data was obtained while characterising the original heated two-tank system. The data can be visualised using the "NWU Heated Two-Tank System Data Visualisation - Original System" Jupyter Notebook
DOI: 10.15151/esrf-es-1393748530
title: Performing in-operando HERFD-XANES studies of the LiNi0.90Mn0.05Co0.05O2 cathode material to investigate the role of oxygen-vacancies on cap

description: The LiNi0.90Mn0.05Co0.05O2 (NMC900505) cathode material can be synthesised under different concentrations of O2, where lower O2 concentrations are likely to introduce higher oxygen-vacancy concentrations in the resulting phases. Here we will investigate samples synthesised under 3 different O2 concentrations and probe the effect that these oxygen-vacancies have on the electronic structure of the Ni, Mn and Co 3d transition metal ions during the 1st charging and discharging cycle. We will use HERFD-XANES measurements taken during operation of the cathode material in order to compare the changes seen for each of the 3 samples.
DOI: 10.25388/nwu.24635151
title: Heated Two-Tank System Data - Original System

description: The experimental data was obtained while characterising the original heated two-tank system. The data can be visualised using the "NWU Heated Two-Tank System Data Visualisation - Original System" Jupyter Notebook
DOI: 10.6084/m9.figshare.24636153
title: YangEtAl_2023_Dataset_Regional flood catalog

description: Regional flood catalog generated using framework proposed in Yang et al., 2023. The catalog is stored in "FloodCatalog.rar" in csv format. Descriptions of each column are summarized in "ReadMe.xlsx".
DOI: 10.5281/zenodo.10208520
title: Clinicopathological differences in MYC and BCL2 protein expression between primary extranodal and nodal diffuse large B-cell lymphoma
DOI: 10.5281/zenodo.10208519
title: Clinicopathological differences in MYC and BCL2 protein expression between primary extranodal and nodal diffuse large B-cell lymphoma
DOI: 10.5281/zenodo.10060589
title: Gridded runoff and evapotranspiration dataset for seven major river basins of the Tibetan Plateau during 1998-2017

description: This data set describes the spatiotemporal distribution of runoff and evapotranspiration for the headwater of seven river basins (the Yellow, Yangtze, Mekong, Salween, Brahmaputra, Ganges, and Indus) in the Tibetan Plateau. This was achieved using an observation-constrained distributed cryosphere-hydrology model, known as the WEB-DHM. The time range is 1998-2017 at a monthly scale, the spatial resolution is 5km×5km, and the unit is mm/month. 
For the convenience of users, this data is stored in TIF format, with each combination of different watersheds forming a separate file. Each file contains two variable: either runoff or evapotranspiration. These files can be opened with ArcGIS, Python, R, and other tools.
DOI: 10.5281/zenodo.10208501
title: Microphysical complexity of black carbon particles restricts their warming potential

description: The data for the figures in the journal article "Microphysical complexity of black carbon particles restricts their warming potential".
DOI: 10.5281/zenodo.10208500
title: Microphysical complexity of black carbon particles restricts their warming potential

description: The data for the figures in the journal article "Microphysical complexity of black carbon particles restricts their warming potential".
DOI: 10.48366/r654014
title: Comparative analysis of Sentinel 2, Landsat 8 and Drone data for Agricultural applications

description: This comparison delves into the effectiveness of Sentinel 2, Landsat 8, and Drone data in agricultural applications, offering science students and professionals valuable insights into optimal remote sensing tools. The study facilitates informed decision-making for precision agriculture, resource management, and crop monitoring, enhancing efficiency and sustainability in agricultural practices.
DOI: 10.5281/zenodo.8251653
title: Online repository for: "Semi-continuous dielectrophoretic separation at high throughput using printed circuit boards"

description: Please consult the readme file for information on the content of this online repository.
DOI: 10.5281/zenodo.8251654
title: Online repository for: "Semi-continuous dielectrophoretic separation at high throughput using printed circuit boards"

description: Please consult the readme file for information on the content of this online repository.
DOI: 10.48366/r654021
title: Advanced Image Classification methods for Crop classification for Sentinel and Landsat datasets

description: This research explores advanced image classification techniques for crop classification using Sentinel and Landsat datasets. The study's findings equip science students and professionals with sophisticated methods to enhance crop monitoring precision. Improved accuracy in crop classification supports informed decision-making in agriculture, benefiting both research and practical applications.
DOI: 10.6084/m9.figshare.19620634
title: Elucidation of molecular diversity and functional characterization of phenanthrene degrading consortium NS-PAH-2015-PNP-5

description: Phenanthrene (PHE) is a hazardous low molecular weight PAH and widespread ecological contaminant. In the present study, the Illumina Miseq platform explored the bacterial diversity of the efficient PHE degrading consortium NS-PAH-2015-PNP-5, developed from the petrochemical contaminated soil near the Indian Oil Corporation Limited refinery, Panipat (India). Total 273 OTUs represented the species diversity identified in NS-PAH-2015-PNP-5. Nineteen major bacterial species covered approximately 99.22% of the total α-diversity of NS-PAH-2015-PNP-5. In NS-PAH-2015-PNP-5, the Shannon alpha diversity (<i>H'</i>) and Pielou's Evenness Index (<i>J'</i>) were calculated at 2.43 and 0.43, respectively. Moreover, an overwhelming population of phylum Proteobacteria (99.28%) and <i>Pseudomonas spp.</i> (32.25%) were observed in NS-PAH-2015-PNP-5. Two culturable isolates, PAH 51 and PAH 52, were isolated from the NS-PAH-2015-PNP-5, and the result of 16S rRNA analysis showed homology with <i>Bacillus wiedmannii</i> (96.7%) and <i>Achromobacter pulmonis</i> (99.24%), respectively. The results of the carbohydrate utilization test showed that NS-PAH-2015-PNP-5 was able to metabolize dextrose, L-arabinose, ONPG, esculin, citrate, and malonate. Detection of phthalic acid metabolite by the GCMS analysis inferred that NS-PAH-2015-PNP-5 bio-degraded the PHE through the protocatechuic acid pathway. During the seven-day biodegradation experiment at the optimized physicochemical conditions, NS-PAH-2015-PNP-5 degraded 62%, 70%, 90% PHE after the third, fifth, and seventh day, respectively. A foremost population of phylum Proteobacteria was identified in NS-PAH-2015-PNP-5.The culturable isolates of NS-PAH-2015-PNP-5 (PAH 51 and PAH 52) didn't utilize PHE as the carbon source.Biodegradation of PHE by the NS-PAH-2015-PNP-5 was accomplished through the protocatechuic acid pathway.<i>Pseudomonas spp.</i> were the most abundant species of the total α-diversity of NS-PAH-2015-PNP-5. A foremost population of phylum Proteobacteria was identified in NS-PAH-2015-PNP-5. The culturable isolates of NS-PAH-2015-PNP-5 (PAH 51 and PAH 52) didn't utilize PHE as the carbon source. Biodegradation of PHE by the NS-PAH-2015-PNP-5 was accomplished through the protocatechuic acid pathway. <i>Pseudomonas spp.</i> were the most abundant species of the total α-diversity of NS-PAH-2015-PNP-5.
DOI: 10.6084/m9.figshare.19620634.v1
title: Elucidation of molecular diversity and functional characterization of phenanthrene degrading consortium NS-PAH-2015-PNP-5

description: Phenanthrene (PHE) is a hazardous low molecular weight PAH and widespread ecological contaminant. In the present study, the Illumina Miseq platform explored the bacterial diversity of the efficient PHE degrading consortium NS-PAH-2015-PNP-5, developed from the petrochemical contaminated soil near the Indian Oil Corporation Limited refinery, Panipat (India). Total 273 OTUs represented the species diversity identified in NS-PAH-2015-PNP-5. Nineteen major bacterial species covered approximately 99.22% of the total α-diversity of NS-PAH-2015-PNP-5. In NS-PAH-2015-PNP-5, the Shannon alpha diversity (<i>H'</i>) and Pielou's Evenness Index (<i>J'</i>) were calculated at 2.43 and 0.43, respectively. Moreover, an overwhelming population of phylum Proteobacteria (99.28%) and <i>Pseudomonas spp.</i> (32.25%) were observed in NS-PAH-2015-PNP-5. Two culturable isolates, PAH 51 and PAH 52, were isolated from the NS-PAH-2015-PNP-5, and the result of 16S rRNA analysis showed homology with <i>Bacillus wiedmannii</i> (96.7%) and <i>Achromobacter pulmonis</i> (99.24%), respectively. The results of the carbohydrate utilization test showed that NS-PAH-2015-PNP-5 was able to metabolize dextrose, L-arabinose, ONPG, esculin, citrate, and malonate. Detection of phthalic acid metabolite by the GCMS analysis inferred that NS-PAH-2015-PNP-5 bio-degraded the PHE through the protocatechuic acid pathway. During the seven-day biodegradation experiment at the optimized physicochemical conditions, NS-PAH-2015-PNP-5 degraded 62%, 70%, 90% PHE after the third, fifth, and seventh day, respectively. A foremost population of phylum Proteobacteria was identified in NS-PAH-2015-PNP-5.The culturable isolates of NS-PAH-2015-PNP-5 (PAH 51 and PAH 52) didn't utilize PHE as the carbon source.Biodegradation of PHE by the NS-PAH-2015-PNP-5 was accomplished through the protocatechuic acid pathway.<i>Pseudomonas spp.</i> were the most abundant species of the total α-diversity of NS-PAH-2015-PNP-5. A foremost population of phylum Proteobacteria was identified in NS-PAH-2015-PNP-5. The culturable isolates of NS-PAH-2015-PNP-5 (PAH 51 and PAH 52) didn't utilize PHE as the carbon source. Biodegradation of PHE by the NS-PAH-2015-PNP-5 was accomplished through the protocatechuic acid pathway. <i>Pseudomonas spp.</i> were the most abundant species of the total α-diversity of NS-PAH-2015-PNP-5.
DOI: 10.6084/m9.figshare.24637302
title: Supplementary Files

description: Supplementary Files for the manuscript from Communications Biology entitled "<b>Exploring a general multi-pronged activation strategy for natural product discovery in Actinomycetes</b>"Abstract:A multi-pronged activation approach was employed to enhance or trigger natural product production across 54 native actinobacterial strains, doubling total metabolite production and enabling discovery of a new tetramic acid analog with gram-negative bioactivity. Insights from this large-scale study could lead to a more streamlined approach to unlock the full potential of nature's chemical resources.
DOI: 10.6084/m9.figshare.24637302.v1
title: Supplementary Files

description: Supplementary Files for the manuscript from Communications Biology entitled "<b>Exploring a general multi-pronged activation strategy for natural product discovery in Actinomycetes</b>"Abstract:A multi-pronged activation approach was employed to enhance or trigger natural product production across 54 native actinobacterial strains, doubling total metabolite production and enabling discovery of a new tetramic acid analog with gram-negative bioactivity. Insights from this large-scale study could lead to a more streamlined approach to unlock the full potential of nature's chemical resources.
DOI: 10.5281/zenodo.10208573
title: Reference model and embedding for human kidney endothelial cell mapping

description: Reference model and embedding for human kidney endothelial cell mapping
The reference model serves as a basis for the mapping of new data to the HLCA using scArches (Lotfollahi et al., https://doi.org/10.1038/s41587-021-01001-7).
DOI: 10.5281/zenodo.10208574
title: Reference model and embedding for human kidney endothelial cell mapping

description: Reference model and embedding for human kidney endothelial cell mapping
The reference model serves as a basis for the mapping of new data to the HLCA using scArches (Lotfollahi et al., https://doi.org/10.1038/s41587-021-01001-7).
DOI: 10.6084/m9.figshare.24637401
title: Supplementary Material for: A Multicenter Phase 2 Trial Evaluating the Efficacy and Safety of Preoperative Lenvatinib Therapy for Patients with Advanced Hepatocellular Carcinoma (LENS-HCC Trial)

description: Introduction: The phase III REFLECT trial demonstrated that lenvatinib was superior to sorafenib in terms of progression-free survival (PFS), time to progression, and objective response rate (ORR) for patients with unresectable hepatocellular carcinoma (HCC). This study assessed the efficacy and safety of preoperative lenvatinib therapy for patients with oncologically or technically unresectable HCC. Methods: In this multicenter single-arm phase II trial, patients with advanced HCC and factors suggestive of a poor prognosis (macroscopic vascular invasion, extrahepatic metastasis, or multinodular tumors) were enrolled. Patients with these factors, even with technically resectable HCC, were defined as oncologically unresectable because of the expected poor prognosis after surgery. After 8 weeks of lenvatinib therapy, the patients were assessed for resectability, and tumor resection was performed if the tumor was considered technically resectable. The primary endpoint was the surgical resection rate. The secondary endpoints were the macroscopic curative resection rate, overall survival (OS), ORR, PFS, and the change in the indocyanine green retention rate at 15 minutes as measured before and after lenvatinib therapy. The trial was registered with the Japan Registry of Clinical Trials (s031190057). Results: Between July 2019 and January 2021, 49 patients (42 oncologically unresectable patients and 7 technically unresectable patients) from 11 centers were enrolled. The ORR was 37.5% based on mRECIST and 12.5% based on RECIST version 1.1. Thirty-three patients underwent surgery (surgical resection rate: 67.3%) without perioperative mortality. The surgical resection rate was 76.2% for oncologically unresectable patients and 14.3% for technically unresectable patients. The 1-year OS rate and median PFS were 75.9% and 7.2 months, respectively, with a median follow-up period of 9.3 months. Conclusions: The relatively high surgical resection rate seen in this study suggests the safety and feasibility of lenvatinib therapy followed by surgical resection for patients with oncologically or technically unresectable HCC.
DOI: 10.6084/m9.figshare.24637407
title: Supplementary Material for: A Multicenter Phase 2 Trial Evaluating the Efficacy and Safety of Preoperative Lenvatinib Therapy for Patients with Advanced Hepatocellular Carcinoma (LENS-HCC Trial)

description: Introduction: The phase III REFLECT trial demonstrated that lenvatinib was superior to sorafenib in terms of progression-free survival (PFS), time to progression, and objective response rate (ORR) for patients with unresectable hepatocellular carcinoma (HCC). This study assessed the efficacy and safety of preoperative lenvatinib therapy for patients with oncologically or technically unresectable HCC. Methods: In this multicenter single-arm phase II trial, patients with advanced HCC and factors suggestive of a poor prognosis (macroscopic vascular invasion, extrahepatic metastasis, or multinodular tumors) were enrolled. Patients with these factors, even with technically resectable HCC, were defined as oncologically unresectable because of the expected poor prognosis after surgery. After 8 weeks of lenvatinib therapy, the patients were assessed for resectability, and tumor resection was performed if the tumor was considered technically resectable. The primary endpoint was the surgical resection rate. The secondary endpoints were the macroscopic curative resection rate, overall survival (OS), ORR, PFS, and the change in the indocyanine green retention rate at 15 minutes as measured before and after lenvatinib therapy. The trial was registered with the Japan Registry of Clinical Trials (s031190057). Results: Between July 2019 and January 2021, 49 patients (42 oncologically unresectable patients and 7 technically unresectable patients) from 11 centers were enrolled. The ORR was 37.5% based on mRECIST and 12.5% based on RECIST version 1.1. Thirty-three patients underwent surgery (surgical resection rate: 67.3%) without perioperative mortality. The surgical resection rate was 76.2% for oncologically unresectable patients and 14.3% for technically unresectable patients. The 1-year OS rate and median PFS were 75.9% and 7.2 months, respectively, with a median follow-up period of 9.3 months. Conclusions: The relatively high surgical resection rate seen in this study suggests the safety and feasibility of lenvatinib therapy followed by surgical resection for patients with oncologically or technically unresectable HCC.