cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.12369926
title: Data item S1.zip

description: The archive contains the transcript annotations analyzed in the study. For a detailed description of its contents please refer to the included Readme.<br>
DOI: 10.6084/m9.figshare.12369947.v1
title: data_schu.txt

description: 1111
DOI: 10.6084/m9.figshare.12369947.v2
title: data_schu.txtprimary production in the Chukchi

description: 1111
DOI: 10.6084/m9.figshare.12369947.v3
title: data_schu.txtprimary production in the Chukchi

description: 1111
DOI: 10.6084/m9.figshare.12369947.v4
title: Mechanisms of the persistent high primary production during the growing season in the Chukchi Sea

description: This item includes the datasets utilized in the article for submission to Ecosystems.
DOI: 10.6084/m9.figshare.12369947.v5
title: Mechanisms of the persistent high primary production during the growing season in the Chukchi Sea

description: This item includes the datasets utilized in the article for submission to Ecosystems.
DOI: 10.6084/m9.figshare.12369947.v6
title: Mechanisms of the persistent high primary production during the growing season in the Chukchi Sea

description: This item includes the datasets utilized in the article for submission to Ecosystems.
DOI: 10.6084/m9.figshare.12369638
title: Supplementary data: Evolutionary history of major chemosensory gene families across Panarthropoda

description: Supplementary data from Evolutionary history of major chemosensory gene families across Panarthropoda.<br>We include the onychophoran E. rowelli transcriptome assembly and annotation, as well as the chemosensory-related gene family databases and annotations described in the article.
DOI: 10.6084/m9.figshare.12369521
title: BITCOIN.xlsx

description: Pre- and postprocedural urinary biomarker concentrations (urinary creatinine ratio) for the BITCOIN population. <br>
DOI: 10.6084/m9.figshare.12369509
title: Supplementary Material for: Inhibition of p38mapk Reduces Adipose Tissue Inflammation in Aging Mediated by Arginase-II

description: <b><i>Background:</i></b> Adipose tissue inflammation occurs not only in obesity but also in aging and is mechanistically linked with age-associated diseases. Studies show that ablation of the l-arginine-metabolizing enzyme arginase-II (Arg-II) reduces adipose tissue inflammation and improves glucose tolerance in obesity. However, the role of Arg-II in aging adipose tissue inflammation is not clear. <b><i>Objective:</i></b> This study investigated the role of Arg-II in age-associated adipose tissue inflammation. <b><i>Methods:</i></b> Visceral adipose tissues of young (3–6 months) and old (20–24 months) wild-type (WT) and Arg-II<sup>−/−</sup> mice were investigated. Immunofluorescence confocal microscopy was performed for analysis of macrophage accumulation and cellular localization of arginase and cytokines; expression of arginase and cytokines was analyzed by qRT-PCR or immunoblotting or ELISA; activation of mitogen-activated protein kinases in adipose tissues was analyzed by immunoblotting; and arginase activity was measured by colorimetric determination of urea production. <b><i>Results:</i></b> In the old WT mice, there is more macrophage accumulation in the visceral adipose tissues than in Arg-II knockout animals. An age-associated increase in arginase activity and Arg-II expression in adipose tissues of WT mice is observed. Arg-II knockout enhances Arg-I expression and activity, but inhibits interleukin (IL)-6 expression and secretion and reduces active p38mapk in aging adipose tissue macrophages and stromal cells. Treatment of aging adipose tissues of WT mice with a specific p38mapk inhibitor SB203580 reduces IL-6 secretion. <b><i>Conclusions:</i></b> Arg-II promotes IL-6 production in aging adipose tissues through p38mapk. The results suggest that targeting Arg-II or inhibiting p38mapk could be beneficial in reducing age-associated adipose tissue inflammation.
DOI: 10.6084/m9.figshare.12369509.v1
title: Supplementary Material for: Inhibition of p38mapk Reduces Adipose Tissue Inflammation in Aging Mediated by Arginase-II

description: <b><i>Background:</i></b> Adipose tissue inflammation occurs not only in obesity but also in aging and is mechanistically linked with age-associated diseases. Studies show that ablation of the l-arginine-metabolizing enzyme arginase-II (Arg-II) reduces adipose tissue inflammation and improves glucose tolerance in obesity. However, the role of Arg-II in aging adipose tissue inflammation is not clear. <b><i>Objective:</i></b> This study investigated the role of Arg-II in age-associated adipose tissue inflammation. <b><i>Methods:</i></b> Visceral adipose tissues of young (3–6 months) and old (20–24 months) wild-type (WT) and Arg-II<sup>−/−</sup> mice were investigated. Immunofluorescence confocal microscopy was performed for analysis of macrophage accumulation and cellular localization of arginase and cytokines; expression of arginase and cytokines was analyzed by qRT-PCR or immunoblotting or ELISA; activation of mitogen-activated protein kinases in adipose tissues was analyzed by immunoblotting; and arginase activity was measured by colorimetric determination of urea production. <b><i>Results:</i></b> In the old WT mice, there is more macrophage accumulation in the visceral adipose tissues than in Arg-II knockout animals. An age-associated increase in arginase activity and Arg-II expression in adipose tissues of WT mice is observed. Arg-II knockout enhances Arg-I expression and activity, but inhibits interleukin (IL)-6 expression and secretion and reduces active p38mapk in aging adipose tissue macrophages and stromal cells. Treatment of aging adipose tissues of WT mice with a specific p38mapk inhibitor SB203580 reduces IL-6 secretion. <b><i>Conclusions:</i></b> Arg-II promotes IL-6 production in aging adipose tissues through p38mapk. The results suggest that targeting Arg-II or inhibiting p38mapk could be beneficial in reducing age-associated adipose tissue inflammation.
DOI: 10.6084/m9.figshare.12369452
title: Variant effect predictor scores used to generate ROC curves

description: Variant effect predictions and DMS data for ClinVar and gnomAD variants in BRCA1, P53, CALM1, PTEN, HRAS and TPK1
DOI: 10.6084/m9.figshare.12369521.v1
title: BITCOIN.xlsx

description: Pre- and postprocedural urinary biomarker concentrations (urinary creatinine ratio) for the BITCOIN population. <br>
DOI: 10.6084/m9.figshare.12369359
title: Raw variant effect predictions and DMS data for benchmarking variant effect predictors.

description: Variant effect predictions made by DEOGEN2, Envision, FATHMM, Fathmm-MKL, FathmmXF, MPC, MutationTaster, MutPred, NetDiseaseSNP, PhD_SNP, PolyPhen2 (HumDiv and HumVar), PonPS, PonP2, PrimateAI, S3D-PROF, SNAP2, SNPs&GO, SNP&GOs3D, SuSPect, VEST4, DeepSequence, fitCons, GenoCanyon, PANTHER, phastCons, PROVEAN, MutationAssessor, BLOSUM62, GERP++, Grantham, LRT, phyloP, SIFT, SIFT4G, SiPhy, CADD, CONDEL, DANN, Eigen, M-CAP, MetaLR, MetaSVM, MVP, PAPI and REVEL. Predictions are made for UBE2I, SUMO1, TPK1, CALM1, BRCA1, P53, HRAS, MAPK1, PTEN, TPMT, ADRB2, HSP82, UBI4, PAB1, GAL4, infA, GmR, bla, ccdB, haeIIIM, Cas9, env, HA-H1N1, HA-H3N2 and PA.
DOI: 10.6084/m9.figshare.12369320
title: Supplementary Material for: Triggers and Clinical Presentations of Functional Neurological Disorders: Lessons from World War 1

description: <b><i>Introduction:</i></b> The psychological contribution to functional neurological and somatic symptom disorders is a major topic in current medical debate. <b><i>Objective:</i></b> For an understanding of the processes leading to functional somatic symptoms, it is paramount to explore their relationship with stress and life events and to elucidate the contribution of cultural factors. <b><i>Methods:</i></b> A total of 937 case records of civilian and military patients with functional somatic disorders treated in London during World War 1 were analysed. Group differences in symptom profiles and contemporaneous diagnoses were tested with χ<sup>2</sup> tests. <b><i>Results:</i></b> Paralyses and speech disturbances were significantly more common in soldiers (43.3 and 17.2% of cases) than in civilian male (28.1 and 6.5%) and female patients (32.4 and 7.5%), whereas female patients had the highest rates of pain (48.6%) and somatic symptoms (67%). Triggers were identified in around two-thirds of cases and included accidents, physical illness, and work stress, in addition to the combat experience of the soldier patients. The nature of the trigger influenced symptom expression, with acute (combat and noncombat) events being particularly prone to trigger loss of motor function. Symptom profiles showed a great deal of multi-morbidity and overlap, although some symptom clusters were more (motor and speech disturbance) or less common (pain and loss of energy) in soldiers than civilians. Triggering life events in civilians were similar to those reported by patients with somatic symptom disorders today, with an important role of physical factors. Patterns of multi-morbidity and symptom clusters also resembled those of modern cohorts. <b><i>Conclusions:</i></b> Analysis of historical records, illness trajectories, and treatments can enhance the understanding of the presentation, mechanisms, and course of functional neurological and related disorders and their consistency over time.
DOI: 10.6084/m9.figshare.12369320.v1
title: Supplementary Material for: Triggers and Clinical Presentations of Functional Neurological Disorders: Lessons from World War 1

description: <b><i>Introduction:</i></b> The psychological contribution to functional neurological and somatic symptom disorders is a major topic in current medical debate. <b><i>Objective:</i></b> For an understanding of the processes leading to functional somatic symptoms, it is paramount to explore their relationship with stress and life events and to elucidate the contribution of cultural factors. <b><i>Methods:</i></b> A total of 937 case records of civilian and military patients with functional somatic disorders treated in London during World War 1 were analysed. Group differences in symptom profiles and contemporaneous diagnoses were tested with χ<sup>2</sup> tests. <b><i>Results:</i></b> Paralyses and speech disturbances were significantly more common in soldiers (43.3 and 17.2% of cases) than in civilian male (28.1 and 6.5%) and female patients (32.4 and 7.5%), whereas female patients had the highest rates of pain (48.6%) and somatic symptoms (67%). Triggers were identified in around two-thirds of cases and included accidents, physical illness, and work stress, in addition to the combat experience of the soldier patients. The nature of the trigger influenced symptom expression, with acute (combat and noncombat) events being particularly prone to trigger loss of motor function. Symptom profiles showed a great deal of multi-morbidity and overlap, although some symptom clusters were more (motor and speech disturbance) or less common (pain and loss of energy) in soldiers than civilians. Triggering life events in civilians were similar to those reported by patients with somatic symptom disorders today, with an important role of physical factors. Patterns of multi-morbidity and symptom clusters also resembled those of modern cohorts. <b><i>Conclusions:</i></b> Analysis of historical records, illness trajectories, and treatments can enhance the understanding of the presentation, mechanisms, and course of functional neurological and related disorders and their consistency over time.
DOI: 10.6084/m9.figshare.12369308
title: RQs

description: Research Questions
DOI: 10.6084/m9.figshare.12369314
title: Metadata record for: The International Bathymetric Chart of the Arctic Ocean Version 4.0

description: This dataset contains key characteristics about the data described in the Data Descriptor The International Bathymetric Chart of the Arctic Ocean Version 4.0. <br> Contents: <br> 1. human readable metadata summary table in CSV format 2. machine readable metadata file in JSON format <br> <br> <br>
DOI: 10.6084/m9.figshare.12369314.v1
title: Metadata record for: The International Bathymetric Chart of the Arctic Ocean Version 4.0

description: This dataset contains key characteristics about the data described in the Data Descriptor The International Bathymetric Chart of the Arctic Ocean Version 4.0. <br> Contents: <br> 1. human readable metadata summary table in CSV format 2. machine readable metadata file in JSON format <br> <br> <br>
DOI: 10.6084/m9.figshare.12369290
title: RQs

description: Research Questions
DOI: 10.6084/m9.figshare.12369281
title: Candidate Tag Set

description: Candidate Tag Set
DOI: 10.6084/m9.figshare.12369293
title: Metadata record for: The Fire and Tree Mortality Database, for empirical modeling of individual tree mortality after fire

description: This dataset contains key characteristics about the data described in the Data Descriptor The Fire and Tree Mortality Database, for empirical modeling of individual tree mortality after fire. <br> Contents: <br> 1. human readable metadata summary table in CSV format 2. machine readable metadata file in JSON format <br> <br> <br>
DOI: 10.6084/m9.figshare.12369278
title: Supplementary Material for: Pecha Kucha with Part-Task Training Improves Airway Management in Fresh Frozen Cadavers: A Case-Control Observational Study

description: <b><i>Objective:</i></b> The objective of this study was to ascertain whether the addition of part-task training as a step in Pecha Kucha for fiberoptic tracheal intubation increases the success rate and reduces the complication rate. <b><i>Subjects and Methods:</i></b> The residents of the Department of Anesthesiology were initially included in an orientation program. We used the Pecha Kucha method for the presentation of teaching fiberoptic intubation skills. Afterwards the participants were trained in Laerdal® airway management and each participant performed tracheal intubation using the Aintree catheter. The participants were divided into two groups. Group 1 (<i>n</i> = 9) received part-task training and group 2 (<i>n</i> = 9) received whole-task training. The tracheal intubation performances of participants were evaluated on fresh frozen cadavers. The number of interventions, incidence of complications, success rate, and optimization maneuver requirements were recorded. <b><i>Results:</i></b> Eighteen residents aged between 27 and 33 years were included. All were junior residents with less than 2 years of experience. There was no significant difference in terms of duration of tracheal intubation, complication rates, and optimization maneuvers between the study groups. Six participants could not place the tracheal tube in the last section. The success rates for the part-task group during Aintree and tracheal tube placement were 100 and 66.7%, respectively, whereas the rates were 55.6 and 44.4%, respectively, in whole-task group (<i>p</i> &lt; 0.05). <b><i>Conclusion:</i></b> In addition to the Pecha Kucha method in fiberoptic intubation training, simulation-based part-task training appears to increase the success rate and to reduce the complication rate on fresh frozen cadavers.
DOI: 10.6084/m9.figshare.12369272
title: Keywords

description: Keywords
DOI: 10.6084/m9.figshare.12369281.v1
title: Candidate Tag Set

description: Candidate Tag Set
DOI: 10.6084/m9.figshare.12369272.v1
title: Keywords

description: Keywords
DOI: 10.6084/m9.figshare.12369308.v1
title: RQs

description: Research Questions
DOI: 10.6084/m9.figshare.12369242
title: Supplementary Material for: Neuropsychiatric Traits Associated with Refractory Impulse Control Disorder in Parkinson’s Disease

description: <b><i>Introduction:</i></b> Impulse control disorder (ICD) in Parkinson’s disease (PD) is a critical nonmotor symptom with personality or neuropsychiatric traits contributing to ICD. <b><i>Objective:</i></b> This study aimed to identify predictive traits for persistent or paradoxical aggravation of ICD after dopamine agonist substitution therapy for ICD in PD. <b><i>Methods:</i></b> We conducted a case-control study using a database of a multicenter intervention trial for ICD in PD. The poor-outcome group was defined by showing paradoxical increases in ICD behaviors after the substitution of dopamine agonists with levodopa. We analyzed the pre-intervention personality traits associated with the poor outcome and also evaluated the risk traits for refractory ICD using a receiver-operating characteristic (ROC) curve analysis. <b><i>Results:</i></b> The poor-outcome group showed higher levels of anger expression (<i>p =</i>0.007) and obsessive-compulsive traits (<i>p =</i>0.009) compared with the good-outcome group at the pre-intervention state. In the ROC curve analysis, the Obsessive-Compulsive Inventory showed the highest area under the curve with 80.0% sensitivity and 74.3% specificity in discriminating against the poor-outcome group. <b><i>Conclusions:</i></b> Our results suggest that assessment of obsessive compulsiveness may be useful for predicting the refractoriness of ICD behaviors in planning an interventional treatment for ICD in PD.
DOI: 10.6084/m9.figshare.12369290.v1
title: RQs

description: Research Questions
DOI: 10.6084/m9.figshare.12369308.v3
title: RQs

description: Research Questions
DOI: 10.6084/m9.figshare.12369227
title: Spatial and Temporal Distribution of Desmostylia (Mammalia)

description: The raw data used in the publication.
DOI: 10.6084/m9.figshare.12369290.v3
title: RQs

description: Research Questions
DOI: 10.6084/m9.figshare.12369227.v1
title: Spatial and Temporal Distribution of Desmostylia (Mammalia)

description: The raw data used in the publication.
DOI: 10.6084/m9.figshare.12369308.v2
title: RQs

description: Research Questions
DOI: 10.5517/ccdc.csd.cc20k4pf
title: CCDC 1863524: Experimental Crystal Structure Determination

description: Related Article: Susan E. Henkelis, Simon M. Vornholt, David B. Cordes, Alexandra M. Z. Slawin, Paul S. Wheatley, Russell E. Morris|2019|CrystEngComm|21|1857|doi:10.1039/C9CE00098D
description: Related Article: Susan Elizabeth Henkelis|2019|Thesis|||
DOI: 10.6084/m9.figshare.12369197
title: Supplementary Material for: Cine-Computed Tomography for the Evaluation of Prosthetic Heart Valve Function

description: <b><i>Background:</i></b> After aortic valve replacement (AVR), suspected prosthetic valve dysfunction (mechanical or biological) may arise based on echocardiographic transvalvular velocities and gradients, leading to reoperative surgical intervention being considered. Our experience has found that 4-dimensional (space and time) image reconstruction of ECG-gated computed tomography, termed cine-CT, may be helpful in such cases. We review and illustrate our experience. <b><i>Methods:</i></b> Twenty-seven AVR patients operated previously by a single surgeon (who performs &gt;100 AVRs/year) were referred for repeat evaluation of suspected aortic stenosis (AS) based on elevated transvalvular velocities and gradients. The patients were fully evaluated by cine-CT. <b><i>Results:</i></b> In all but 2 cases, the cine-CT strikingly and visually confirmed normal leaflet function and excursion, with no valve thrombosis, restriction by pannus, or obstruction by clot. In only 2 cases did cine-CT reveal decreased mechanical valve leaflet excursion. Repeat surgery was required in only 1 case while all other patients continued clinically without cardiac events. <b><i>Conclusions:</i></b> Echocardiography is an extraordinarily useful tool for the evaluation of prosthetic valve function. Increased pressure recovery beyond the valve and other factors may occasionally lead to exaggerated gradients. Cine-CT is emerging as an extremely valuable tool for further evaluation of suspected prosthetic valve AS. Our experience has been extremely helpful, as is shown in the dramatically reassuring images.
DOI: 10.6084/m9.figshare.12369203
title: A Survey on the Interplay between Software Engineering and Systems Engineering during SoS Architecting - replication package

description: Replication package of the paper <i>A Survey on the Interplay between Software Engineering and Systems Engineering during SoS Architecting. </i>Paper accepted on the <i>Empirical Software Engineering and Measurement</i> Conference (ESEM), 2020.<br><i><br></i>
DOI: 10.6084/m9.figshare.12369236.v1
title: FT-ICR-MS-combined.csv

description: FT-ICR MS data set for the experiment of Synechococcus-derived DOM addition in coastal ocean.
DOI: 10.6084/m9.figshare.12369290.v2
title: RQs

description: Research Questions
DOI: 10.5517/ccdc.csd.cc20k4mc
title: CCDC 1863522: Experimental Crystal Structure Determination

description: Related Article: Susan E. Henkelis, Simon M. Vornholt, David B. Cordes, Alexandra M. Z. Slawin, Paul S. Wheatley, Russell E. Morris|2019|CrystEngComm|21|1857|doi:10.1039/C9CE00098D
description: Related Article: Susan Elizabeth Henkelis|2019|Thesis|||
DOI: 10.6084/m9.figshare.12369182
title: Supplementary Material for: Follow-Up Ileocolonoscopy Is Underused in Crohn’s Disease Patients after Ileocecal Resection despite Higher Total and Inpatient Health-Care Costs Compared to Controls

description: <b><i>Background:</i></b> Postoperative recurrence is frequently observed after ileocecal resection in Crohn’s disease (CD) patients. Since 2010, endoscopy within 1 year is considered the gold standard for its diagnosis. However, if and how frequent such endoscopies are performed in clinical practice remains unknown. <b><i>Methods:</i></b> We analyzed 1-year follow-up data on CD patients who underwent ileocecal resection between 2012 and 2014 and compared them with hospitalized, non-resected CD controls. Data were extracted from the Helsana database. Helsana is one of the largest Swiss health insurance companies providing coverage for 1.2 million individuals. <b><i>Results:</i></b> A total of 645 CD patients were identified with ≥1 hospitalization between 2012 and 2014 and a follow-up of 1 year. Of these, 79 (12.2%) underwent ileocecal resection. Although endoscopy rates increased over time and were higher in patients with resection versus controls (<i>p</i> = 0.029), in only 54.4% a 1-year follow-up ileocolonoscopy was performed. Postoperative prophylaxis with anti-tumor necrosis factor or azathioprine was prescribed in 63.3%. Female sex and age &gt;60 years were independent predictors for not receiving prophylaxis (odds ratio [OR] 0.36, <i>p</i> = 0.048, and OR 0.2, <i>p</i> = 0.022). Patients with resection had significantly lower numbers of rehospitalizations (1.2 vs. 1.8, <i>p</i> = 0.021), with resection being an independent negative predictor for number of rehospitalizations in a Poisson regression model (incident risk ratio 0.64, <i>p</i> = 0.029). However, disease-related surgery was more often the cause for rehospitalization after resection versus controls (47.6 vs. 22.1%, <i>p</i> = 0.015). Total and inpatient health-care costs were higher in these patients. <b><i>Conclusion:</i></b> Endoscopies are underused after ileocecal resection. This contrasts current guidelines. Physicians should be aware of this underuse and perform follow-up examinations more often.