DOI: 10.7910/dvn/2eh7xs
title: A5322: Long-Term Follow-up of Older HIV-infected Adults in the ACTG: Addressing Issues of Aging, HIV Infection and Inflammation (HAILO)
title: SAS transport files and associated documentation
title: A5322 Final Analysis Datasets

description: DESIGN: The A5322 protocol is a long-term observational study, with a planned series of analyses of data to be collected from an established longitudinal study of participants living with HIV. At the time of enrollment in A5322, these participants were enrolled and followed in the Adult AIDS Clinical Trials Group Longitudinal Linked Randomized Trials (ALLRT) study (A5001) (or had recently completed follow-up in ALLRT [A5001]), which had enrolled participants who received their first immune-based or antiretroviral therapies (ART) or treatment strategies through randomized ACTG clinical trials. These participants will be followed for the purposes of evaluating clinical, virologic, and immunologic outcomes and their potential associations with long-term treatment with potent ART and aging. &lt;br&gt;&lt;br&gt;
DURATION: Participants will be followed for 336 weeks (~7 years). &lt;br&gt;&lt;br&gt;
SAMPLE SIZE: Closed to accrual on July 31, 2014; 1035 evaluable participants were entered into the study. &lt;br&gt;&lt;br&gt;
POPULATION: Participants actively followed in the ALLRT (A5001) at the time of enrollment into A5322 or completed follow-up in ALLRT (A5001) and enrolled into A5322 no later than July 31, 2014, who were ART-naïve at the time of enrollment into their ALLRT (A5001) parent protocol, and who were 40 years of age or older at their time of enrollment into A5322. Eligible participants must agree to be followed long-term for clinical, virologic, and immunologic outcomes. &lt;br&gt;&lt;br&gt;
Planned enrollment included approximately 22% female participants (corresponding to the proportion of A5322-eligible female participants) aged 40 years and older who were being followed in ALLRT (A5001). &lt;br&gt;&lt;br&gt;
REGIMEN: Treatment for HIV infection must be arranged independently of the A5322 protocol. No treatment is provided through the A5322 protocol
description: USING THE SAS FILES: The SAS transport file (.trn) contains the datasets for this study. 
To use the unpacking program provided (unpack.sas), place the program and the SAS transport (.trn) file in the same directory, then run unpack.sas using SAS. The files will unpack into that directory.
Please note that the unpacking program must be used because of the way SAS handles transferring datasets from one computer system to another. A file named format.values.lst is provided to provide information about SAS formats.

NOTES ABOUT THE DE-IDENTIFIED FILES: The data are de-identified so that no original identifiers are included in the data files. 
In order to de-identify data for public use, all dates have been converted to the number of days from a reference date.
The SAS labels specify the start day for the calculation of the number of days in the variable. 
All site and institution information has been removed. 
Also, any other variable that has been deemed inappropriate to include in these public use datasets has been removed. 
This might limit how the files can be used. The de-identification process has been done in response to current regulatory requirements. 

RAW DATA FILES: The zip file contains comma separated value (.csv) files for this study.

ADDITIONAL INFORMATION: Additional information concerning the data can be found in the file documentation files and metadata.csv.