cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.9873932
title: Supplementary Material for: Influence of Buffers of Different pH and Composition on the Murine Skin Barrier, Epidermal Proliferation, Differentiation, and Inflammation

description: The pH of the skin is tightly regulated by endogenous buffering systems. We examined the influence of buffers of different pH and composition on skin barrier repair, pH, inflammation, and epidermal thickness/proliferation/differentiation. After tape-stripping in hairless mice buffers with pH 4–7 were applied in patch test chambers. After removal of the chambers, skin pH and transepidermal water loss (TEWL) were monitored for 24 h, and biopsies were taken for histology/immunohistology. Hairless mice showed a basal skin pH of about 5.8. Following barrier disruption and application of water, the pH increased by 0.6 units; increase in pH was reduced by the pH 4 glycolate buffer, unchanged by pH 4 citrate and pH 5.5 buffers, and even increased by the pH 7 buffer. pH 5.5, pH 4 citrate, and pH 4 glycolate buffers led to a slight, while the pH 7 buffer led to a significant increase in TEWL after barrier disruption compared to water. The pH 7 buffers led to a significant increase in epidermal thickness/proliferation/differentiation and inflammation after barrier disruption, whereas buffers with pH 4 and 5.5 caused a slight increase. In conclusion, only the pH 4 glycolate buffer significantly reduced the skin barrier disruption-related increase in skin pH. This was accompanied by only slight increase in epidermal thickness and inflammation compared to water. Application of the pH 7 buffer led to a significant increase in the skin pH, TEWL, epidermal thickness, and inflammation. The results are important for the formulation of topical products for effective acidification in pathological skin conditions.
DOI: 10.6084/m9.figshare.9874028.v1
title: Metadata record for: The ENERTALK dataset, 15 Hz electricity consumption data from 22 houses in Korea

description: This dataset contains key characteristics about the data described in the Data Descriptor The ENERTALK dataset, 15 Hz electricity consumption data from 22 houses in Korea. <br> Contents: <br> 1. human readable metadata summary table in CSV format 2. machine readable metadata file in JSON format <br> <br> <br>
DOI: 10.6084/m9.figshare.9873944.v1
title: Data set for Chapter 10. Catalan Teenagers’ Identity, Literacy and Language Practices on YouTube

description: This a data set for "Chapter 10. Catalan Teenagers’ Identity, Literacy and Language Practices on YouTube," to appear in an edited volume on technology-enhanced language learning and psychology.
DOI: 10.6084/m9.figshare.9873944.v2
title: Dataset for Chapter 10. Catalan Teenagers’ Identity, Literacy and Language Practices on YouTube

description: This a dataset for "Chapter 10. Catalan Teenagers’ Identity, Literacy and Language Practices on YouTube," to appear in an edited volume on technology-enhanced language learning and psychology.
DOI: 10.6084/m9.figshare.9873944.v4
title: Dataset for Chapter 10. Catalan Teenagers’ Identity, Literacy and Language Practices on YouTube

description: This a dataset for "Chapter 10. Catalan Teenagers’ Identity, Literacy and Language Practices on YouTube," to appear in an edited volume on technology-enhanced language learning and psychology.
DOI: 10.6084/m9.figshare.9873944.v3
title: Data set for Chapter 10. Catalan Teenagers’ Identity, Literacy and Language Practices on YouTube

description: This a data set for "Chapter 10. Catalan Teenagers’ Identity, Literacy and Language Practices on YouTube," to appear in an edited volume on technology-enhanced language learning and psychology.
DOI: 10.15131/shef.data.9873731
title: Utility calculator for visual acuity

description: Please see readme.txt
DOI: 10.6084/m9.figshare.9873701
title: ncomm_McLaughlin_2019.xlsx

description: The information in this file summarizes the data used to generate the plots in the article entitled <b>"Injectable human recombinant collagen matrices limit adverse remodeling and improve cardiac function after myocardial infarction" by </b>McLaughlin et al. This data is property of University of Ottawa Heart Institute Research Corporation.
DOI: 10.15131/shef.data.9873731.v1
title: Utility calculator for visual acuity

description: Please see readme.txt
DOI: 10.6084/m9.figshare.9873665
title: Supplementary Material for: Factors That Influence Habitual Activity in Mild Cognitive Impairment and Dementia

description: <b><i>Background:</i></b> Reduced engagement with habitual activity (HA) is associated with greater risk and progression of cognitive decline and falls in older adults and people with dementia. Understanding external and intrinsic factors that affect HA may provide novel targets for non-pharmacologic interventions. <b><i>Objective:</i></b> This study primarily aims to identify factors that influence HA in normal ageing and cognitive impairment, such as cognitive and motor problems and disease subtype. <b><i>Methods:</i></b> 108 older adults participated in this study; 36 with cognitive impairment due to Alzheimer’s disease (AD), 30 with dementia with Lewy bodies (DLB), 16 with Parkinson’s disease dementia (PDD), and 26 controls. A tri-axial accelerometer recorded continuous data of volume, variability, and pattern of HA over 7 days. Participants undertook a battery of cognitive and neuropsychological assessments. <b><i>Results:</i></b> One-way analysis of variance controlling for age and gender shows that people with DLB and PDD engage less with HA than controls (<i>p</i> ≤ 0.01), but there were no significant differences between AD and controls (<i>p</i> ≥ 0.01). Multivariate analysis demonstrated motor disease and impairments in activities of daily living (ADLs) independently explained 10–26% of volume, variability, and pattern of HA in people with cognitive impairment. <b><i>Conclusion:</i></b> People with cognitive impairment have reduced HA engagement compared to controls. Motor disease and impairments in ADLs most strongly contribute to these findings and may be important to consider for disease management. Wearable technology can provide a personalised picture of an individual’s daily behaviours and may be a useful tool for person-centred care.
DOI: 10.6084/m9.figshare.9873665.v1
title: Supplementary Material for: Factors That Influence Habitual Activity in Mild Cognitive Impairment and Dementia

description: <b><i>Background:</i></b> Reduced engagement with habitual activity (HA) is associated with greater risk and progression of cognitive decline and falls in older adults and people with dementia. Understanding external and intrinsic factors that affect HA may provide novel targets for non-pharmacologic interventions. <b><i>Objective:</i></b> This study primarily aims to identify factors that influence HA in normal ageing and cognitive impairment, such as cognitive and motor problems and disease subtype. <b><i>Methods:</i></b> 108 older adults participated in this study; 36 with cognitive impairment due to Alzheimer’s disease (AD), 30 with dementia with Lewy bodies (DLB), 16 with Parkinson’s disease dementia (PDD), and 26 controls. A tri-axial accelerometer recorded continuous data of volume, variability, and pattern of HA over 7 days. Participants undertook a battery of cognitive and neuropsychological assessments. <b><i>Results:</i></b> One-way analysis of variance controlling for age and gender shows that people with DLB and PDD engage less with HA than controls (<i>p</i> ≤ 0.01), but there were no significant differences between AD and controls (<i>p</i> ≥ 0.01). Multivariate analysis demonstrated motor disease and impairments in activities of daily living (ADLs) independently explained 10–26% of volume, variability, and pattern of HA in people with cognitive impairment. <b><i>Conclusion:</i></b> People with cognitive impairment have reduced HA engagement compared to controls. Motor disease and impairments in ADLs most strongly contribute to these findings and may be important to consider for disease management. Wearable technology can provide a personalised picture of an individual’s daily behaviours and may be a useful tool for person-centred care.
DOI: 10.6084/m9.figshare.9873701.v1
title: ncomm_McLaughlin_2019.xlsx

description: The information in this file summarizes the data used to generate the plots in the article entitled <b>"Injectable human recombinant collagen matrices limit adverse remodeling and improve cardiac function after myocardial infarction" by </b>McLaughlin et al. This data is property of University of Ottawa Heart Institute Research Corporation.
DOI: 10.6084/m9.figshare.9873701.v2
title: ncomm_McLaughlin_2019.xlsx

description: The information in this file summarizes the data used to generate the plots in the article entitled <b>"Injectable human recombinant collagen matrices limit adverse remodeling and improve cardiac function after myocardial infarction" by </b>McLaughlin et al. This data is property of University of Ottawa Heart Institute Research Corporation.
DOI: 10.6084/m9.figshare.9873596
title: The investigation of the G-quadruplex aptamer selectivity to Pb<sup>2+</sup> ion: a joint molecular dynamics simulation and density functional theory study

description: The aptamers with the ability to form a G-quadruplex structure can be stable in the presence of some ions. Hence, study of the interactions between such aptamers and ions can be beneficial to determine the highest selective aptamer toward an ion. In this article, molecular dynamics (MD) simulations and quantum mechanics (QM) calculations have been applied to investigate the selectivity of the T30695 aptamer toward Pb<sup>2+</sup> in comparison with some ions. The Free Energy Landscape (FEL) analysis indicates that Pb<sup>2+</sup> has remained inside the aptamer during the MD simulation, while the other ions have left it. The Molecular Mechanics Poisson-Boltzmann Surface Area (MM-PBSA) binding energies prove that the conformational stability of the aptamer is the highest in the presence of Pb<sup>2+</sup>. According to the compaction parameters, the greatest compressed ion-aptamer complex, and hence, the highest ion-aptamer interaction have been induced in the presence of Pb<sup>2+</sup>. The contact maps clarify the closer contacts between the nucleotides of the aptamer in the presence of Pb<sup>2+</sup>. The density functional theory (DFT) results show that Pb<sup>2+</sup> forms the most stable complex with the aptamer, which is consistent with the MD results. The QM calculations reveal that the N-H bonds and the O…H distances are the longest and the shortest, respectively, in the presence of Pb<sup>2+</sup>. The obtained results verify that the strongest hydrogen bonds (HBs), and hence, the most compressed aptamer structure are induced by Pb<sup>2+</sup>. Besides, atoms in molecules (AIM) and natural bond orbital (NBO) analyses confirm the results. Communicated by Ramaswamy H. Sarma
DOI: 10.6084/m9.figshare.9873596.v1
title: The investigation of the G-quadruplex aptamer selectivity to Pb<sup>2+</sup> ion: a joint molecular dynamics simulation and density functional theory study

description: The aptamers with the ability to form a G-quadruplex structure can be stable in the presence of some ions. Hence, study of the interactions between such aptamers and ions can be beneficial to determine the highest selective aptamer toward an ion. In this article, molecular dynamics (MD) simulations and quantum mechanics (QM) calculations have been applied to investigate the selectivity of the T30695 aptamer toward Pb<sup>2+</sup> in comparison with some ions. The Free Energy Landscape (FEL) analysis indicates that Pb<sup>2+</sup> has remained inside the aptamer during the MD simulation, while the other ions have left it. The Molecular Mechanics Poisson-Boltzmann Surface Area (MM-PBSA) binding energies prove that the conformational stability of the aptamer is the highest in the presence of Pb<sup>2+</sup>. According to the compaction parameters, the greatest compressed ion-aptamer complex, and hence, the highest ion-aptamer interaction have been induced in the presence of Pb<sup>2+</sup>. The contact maps clarify the closer contacts between the nucleotides of the aptamer in the presence of Pb<sup>2+</sup>. The density functional theory (DFT) results show that Pb<sup>2+</sup> forms the most stable complex with the aptamer, which is consistent with the MD results. The QM calculations reveal that the N-H bonds and the O…H distances are the longest and the shortest, respectively, in the presence of Pb<sup>2+</sup>. The obtained results verify that the strongest hydrogen bonds (HBs), and hence, the most compressed aptamer structure are induced by Pb<sup>2+</sup>. Besides, atoms in molecules (AIM) and natural bond orbital (NBO) analyses confirm the results. Communicated by Ramaswamy H. Sarma
DOI: 10.6084/m9.figshare.9873446
title: <i>In vitro</i> DNA binding activity and molecular docking reveals pierisin-5 as an anti-proliferative agent against gastric cancer

description: Pierisin-5 is a DNA dependent ADP ribosyltransferase (ADRT) protein from the larvae of Indian cabbage white butterfly, <i>Pieris canidia.</i> Interestingly, Pierisin-5 ADP-ribosylates the DNA as a substrate, but not the protein and subsequently persuades apoptotic cell death in human cancer cells. This has led to the investigation on the DNA binding activity of Pierisin-5 using <i>in vitro</i> and <i>in silico</i> approaches in the present study. However, both the structure and the mechanism of ADP-ribosylation of pierisin-5 are unknown. <i>In silico</i> modeled structure of the N-terminal ADRT catalytic domain interacted with the minor groove of B-DNA for ribosylation with the help of β-NAD<sup>+</sup> which lead to a structural modification in DNA (DNA adduct). The possible interaction between calf thymus DNA (CT-DNA) and purified pierisin-5 protein was studied through spectral–spatial studies and the blue shift and hyperchromism in the UV–Visible spectra was observed. The DNA adduct property of pierisin-5 protein was validated by <i>in vitro</i> cytotoxic assay on human gastric (AGS) cancer cell lines. Our study is the first report of the mechanism of DNA binding property of pierisin-5 protein which leads to the induction of cytotoxicity and apoptotic cell death against cancer cell lines. Communicated by Ramaswamy H. Sarma
DOI: 10.6084/m9.figshare.9873446.v1
title: <i>In vitro</i> DNA binding activity and molecular docking reveals pierisin-5 as an anti-proliferative agent against gastric cancer

description: Pierisin-5 is a DNA dependent ADP ribosyltransferase (ADRT) protein from the larvae of Indian cabbage white butterfly, <i>Pieris canidia.</i> Interestingly, Pierisin-5 ADP-ribosylates the DNA as a substrate, but not the protein and subsequently persuades apoptotic cell death in human cancer cells. This has led to the investigation on the DNA binding activity of Pierisin-5 using <i>in vitro</i> and <i>in silico</i> approaches in the present study. However, both the structure and the mechanism of ADP-ribosylation of pierisin-5 are unknown. <i>In silico</i> modeled structure of the N-terminal ADRT catalytic domain interacted with the minor groove of B-DNA for ribosylation with the help of β-NAD<sup>+</sup> which lead to a structural modification in DNA (DNA adduct). The possible interaction between calf thymus DNA (CT-DNA) and purified pierisin-5 protein was studied through spectral–spatial studies and the blue shift and hyperchromism in the UV–Visible spectra was observed. The DNA adduct property of pierisin-5 protein was validated by <i>in vitro</i> cytotoxic assay on human gastric (AGS) cancer cell lines. Our study is the first report of the mechanism of DNA binding property of pierisin-5 protein which leads to the induction of cytotoxicity and apoptotic cell death against cancer cell lines. Communicated by Ramaswamy H. Sarma
DOI: 10.6084/m9.figshare.9873422
title: Pre-existing medical disorders as risk factors for preeclampsia: an exploratory case-control study

description: <b>Objective</b>: We sought to explore pre-existing medical disorders as risk factors for preeclampsia as thoroughly as possible. <b>Methods</b>: A case-control design. A group of 1,652 patients were identified as the preeclampsia group, and another randomly selected 4,500 patients were identified as the non-preeclampsia group. <b>Results</b>: Mature ovarian teratoma (adjusted odds ratio [OR] 7.69, 95% CI 1.58–37.53), uterine fibroids (adjusted OR 2.24, 95% CI 1.28–3.92) and pregestational hypothyroidism (adjusted OR 5.17, 95% CI 2.43–11.00), were significantly correlated with preeclampsia. <b>Conclusions</b>: Mature ovarian teratoma, uterine fibroids and pregestational hypothyroidism may also contribute to the incidence of preeclampsia.
DOI: 10.6084/m9.figshare.9873422.v1
title: Pre-existing medical disorders as risk factors for preeclampsia: an exploratory case-control study

description: <b>Objective</b>: We sought to explore pre-existing medical disorders as risk factors for preeclampsia as thoroughly as possible. <b>Methods</b>: A case-control design. A group of 1,652 patients were identified as the preeclampsia group, and another randomly selected 4,500 patients were identified as the non-preeclampsia group. <b>Results</b>: Mature ovarian teratoma (adjusted odds ratio [OR] 7.69, 95% CI 1.58–37.53), uterine fibroids (adjusted OR 2.24, 95% CI 1.28–3.92) and pregestational hypothyroidism (adjusted OR 5.17, 95% CI 2.43–11.00), were significantly correlated with preeclampsia. <b>Conclusions</b>: Mature ovarian teratoma, uterine fibroids and pregestational hypothyroidism may also contribute to the incidence of preeclampsia.
DOI: 10.6084/m9.figshare.9873284
title: test_figshare.txt

description: dummy
DOI: 10.6084/m9.figshare.9873287
title: Eriz data

description: The folder contains the landslide inventory data (landslide.xlsx), the rainfall time series of the triggering storm (rainfall.xlsx), the DEM (dem.txt), and the map of forest (forest.txt) in the Eriz catchment, Switzerland. The recorded landslide attributes include: coordinates and elevation (measured at the top of each landslide), average slope, maximum width, maximum length, area, and volume. The triggering rainfall storm lasted for 150 minutes from 3.00 pm to 5.30 pm on 4 July 2012. Rainfall intensity at each minute is recorded in the rainfall.txt file. The DEM and forest map are projected to the spatial reference of CH1903_LV03. A value of 1 in the forest.txt file represents meadow/bare soil and a value of 2 represents forest.
DOI: 10.6084/m9.figshare.9873278
title: Look_Out_v2_Experiment _Data.zip

description: Eye and IMU data
DOI: 10.6084/m9.figshare.9873284.v1
title: test_figshare.txt

description: dummy
DOI: 10.6084/m9.figshare.9873212
title: Supplementary Material for: The Eighth Edition of the American Joint Committee on Cancer Distant Metastases Stage Classification for Metastatic Pancreatic Neuroendocrine Tumors Might Be Feasible for Metastatic Pancreatic Ductal Adenocarcinomas

description: <b><i>Background:</i></b> Significant modifications have been made to the 8th edition of the American Joint Committee on Cancer (AJCC) distant metastases (M) stage classification for metastatic pancreatic neuroendocrine tumors (PanNETs). We aimed to validate this revised classification among metastatic PanNET patients using the Surveillance, Epidemiology, and End Results database. We further sought to evaluate the feasibility of applying this classification to metastatic pancreatic neuroendocrine carcinoma (PanNEC) and pancreatic ductal adenocarcinoma (PDAC) patients. <b><i>Methods:</i></b> Stage IV pancreatic neuroendocrine neoplasm (PanNEN, including G1/G2 PanNET and G3 PanNEC classified according to the World Health Organization [WHO] 2010 grading scheme) and PDAC patients with metastatic disease diagnosed between 2010 and 2015 were identified and restaged according to the revised M stage classification for PanNET. Overall survival (OS) was compared using Kaplan-Meier analysis and log-rank test. Uni- and multivariate Cox regression models were utilized to identify prognostic factors. <b><i>Results:</i></b> A total of 1,371 stage IV PanNEN and 634 PDAC patients were included. Among PanNEN patients, liver (75.0%) was the most common metastatic site, followed by distant lymph nodes (8.5%), lung (8.4%), bone (7.3%), and brain (1.0%). The 5-year OS for PanNET patients with M1a, M1b, and M1c stage was 44.15, 53.32, and 19.70%, respectively. However, survival comparison showed no significant difference between M1a and M1b stages among PanNET patients. Similar findings were noted after applying this classification to PanNEC patients. Multivariate analysis showed that the age at diagnosis and the number of distant metastatic sites were independent prognostic factors for metastatic PanNEN patients. Interestingly, excellent survival discrimination by M stage among stage IV PDAC patients was noted (M1a vs. M1b vs. M1c, 5-year OS: 5.42, 2.46, and 0%, respectively). <b><i>Conclusion:</i></b> Our study is the first large sample-based validation of the AJCC 8th M stage classification for PanNET. The revised classification did not effectively stratify metastatic PanNEN patients. However, further study is warranted to validate this classification for PanNET patients according to the WHO 2017 classification. Interestingly, the revised M stage classification might be feasible for PDAC patients with metastatic disease.
DOI: 10.6084/m9.figshare.9873278.v1
title: Look_Out_v2_Experiment _Data.zip

description: Eye and IMU data