cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.4286318
title: Development of an internet version of the Lidcombe Program of early stuttering intervention: A trial of Part 1

description: <i>Purpose</i>: There is evidence that access to treatment for early stuttering is not available for all who need it. An internet version of the Lidcombe Program for early stuttering (Internet-LP) has been developed to deal with this shortfall. The LP is suitable for such development because it is delivered by parents in the child’s everyday environment, with training by a speech-language pathologist. A Phase I trial of Internet-LP Part 1, comprising parent training, is reported here. <i>Method</i>: Eight parents of pre-schoolers who stutter were recruited and six completed the trial. <i>Result</i>: Post-trial assessment indicated that the parents scored well for identifying and measuring stuttering and for knowledge about conducting practice sessions, including how to present verbal contingencies during practice sessions. <i>Conclusion</i>: The results prompted minor adjustments to Part 1 and guided the construction of Part 2, which instructs parents during the remainder of the treatment process.
DOI: 10.6084/m9.figshare.4286321
title: Persistent hemifacial spasm after microvascular decompression: a risk assessment model

description: <b>Objective:</b> Microvascular decompression (MVD) for hemifacial spasm (HFS) provides resolution of disabling symptoms such as eyelid twitching and muscle contractions of the entire hemiface. The primary aim of this study was to evaluate the predictive value of patient demographics and spasm characteristics on long-term outcomes, with or without intraoperative lateral spread response (LSR) as an additional variable in a risk assessment model. <b>Methods:</b> A retrospective study was undertaken to evaluate the associations of pre-operative patient characteristics, as well as intraoperative LSR and need for a staged procedure on the presence of persistent or recurrent HFS at the time of hospital discharge and at follow-up. A risk assessment model was constructed with the inclusion of six clinically or statistically significant variables from the univariate analyses. A receiving operator characteristic curve was generated, and area under the curve was calculated to determine the strength of the predictive model. <b>Results:</b> A risk assessment model was first created consisting of significant pre-operative variables (Model 1) (age &gt;50, female gender, history of botulinum toxin use, platysma muscle involvement). This model demonstrated borderline predictive value for persistent spasm at discharge (AUC .60; <i>p</i>=.045) and fair predictive value at follow-up (AUC .75; <i>p</i>=.001). Intraoperative variables (e.g. LSR persistence) demonstrated little additive value (Model 2) (AUC .67). Patients with a higher risk score (three or greater) demonstrated greater odds of persistent HFS at the time of discharge (OR 1.5 [95%CI 1.16–1.97]; <i>p</i>=.035), as well as greater odds of persistent or recurrent spasm at the time of follow-up (OR 3.0 [95%CI 1.52–5.95]; <i>p</i>=.002) <b>Conclusions:</b> A risk assessment model consisting of pre-operative clinical characteristics is useful in prognosticating HFS persistence at follow-up.
DOI: 10.6084/m9.figshare.4286318.v1
title: Development of an internet version of the Lidcombe Program of early stuttering intervention: A trial of Part 1

description: <i>Purpose</i>: There is evidence that access to treatment for early stuttering is not available for all who need it. An internet version of the Lidcombe Program for early stuttering (Internet-LP) has been developed to deal with this shortfall. The LP is suitable for such development because it is delivered by parents in the child’s everyday environment, with training by a speech-language pathologist. A Phase I trial of Internet-LP Part 1, comprising parent training, is reported here. <i>Method</i>: Eight parents of pre-schoolers who stutter were recruited and six completed the trial. <i>Result</i>: Post-trial assessment indicated that the parents scored well for identifying and measuring stuttering and for knowledge about conducting practice sessions, including how to present verbal contingencies during practice sessions. <i>Conclusion</i>: The results prompted minor adjustments to Part 1 and guided the construction of Part 2, which instructs parents during the remainder of the treatment process.
DOI: 10.6084/m9.figshare.4286321.v1
title: Persistent hemifacial spasm after microvascular decompression: a risk assessment model

description: <b>Objective:</b> Microvascular decompression (MVD) for hemifacial spasm (HFS) provides resolution of disabling symptoms such as eyelid twitching and muscle contractions of the entire hemiface. The primary aim of this study was to evaluate the predictive value of patient demographics and spasm characteristics on long-term outcomes, with or without intraoperative lateral spread response (LSR) as an additional variable in a risk assessment model. <b>Methods:</b> A retrospective study was undertaken to evaluate the associations of pre-operative patient characteristics, as well as intraoperative LSR and need for a staged procedure on the presence of persistent or recurrent HFS at the time of hospital discharge and at follow-up. A risk assessment model was constructed with the inclusion of six clinically or statistically significant variables from the univariate analyses. A receiving operator characteristic curve was generated, and area under the curve was calculated to determine the strength of the predictive model. <b>Results:</b> A risk assessment model was first created consisting of significant pre-operative variables (Model 1) (age &gt;50, female gender, history of botulinum toxin use, platysma muscle involvement). This model demonstrated borderline predictive value for persistent spasm at discharge (AUC .60; <i>p</i>=.045) and fair predictive value at follow-up (AUC .75; <i>p</i>=.001). Intraoperative variables (e.g. LSR persistence) demonstrated little additive value (Model 2) (AUC .67). Patients with a higher risk score (three or greater) demonstrated greater odds of persistent HFS at the time of discharge (OR 1.5 [95%CI 1.16–1.97]; <i>p</i>=.035), as well as greater odds of persistent or recurrent spasm at the time of follow-up (OR 3.0 [95%CI 1.52–5.95]; <i>p</i>=.002) <b>Conclusions:</b> A risk assessment model consisting of pre-operative clinical characteristics is useful in prognosticating HFS persistence at follow-up.
DOI: 10.6084/m9.figshare.4286216
title: Time series data for experimental functional runs (VTC files)

description: These are the time series files for each experimental run of the experiment for 'Understanding the goals of Everyday instrumental actions is primarily linked to Object, not Motor-Kinematic, information: Evidence from fmri' http://dx.doi.org/10.1371/journal.pone.0169700
DOI: 10.6084/m9.figshare.4286255
title: A new amynodontid from the Eocene of South China and phylogeny of Amynodontidae (Perissodactyla: Rhinocerotoidea)

description: <i>Cadurcodon maomingensis</i> sp. nov. is described based on a partial skull and associated vertebrae from the middle–upper Eocene Youganwo Formation in the Maoming Basin, Guangdong Province, China. The taxonomy of <i>Cadurcodon</i> Kretzoi, 1942 ( = <i>Sianodon</i> Xu, 1965, syn. nov.; = <i>Paracadurcodon</i> Xu, 1966, syn. nov.) is revised, and a new diagnosis of the genus is provided. It includes six species: <i>C. ardynensis</i> (Osborn, 1923), <i>C. kazakademius</i> Biryukov, 1961, <i>C. bahoensis</i> (Xu, 1965) comb. nov., <i>C. suhaituensis</i> (Xu, 1966) comb. nov., <i>C. houldjinensis</i> B.-Y. Wang, Qiu, Zhang, Wu, & Ning, 2009 and <i>C. maomingensis</i> sp. nov. A new phylogenetic hypothesis of Amynodontidae is based on the cladistic analysis of the distribution of 48 characters in 16 amynodontid taxa. The family is divided into two sister taxa, Metamynodontini (<i>Paramynodon</i>, <i>Megalamynodon</i> and <i>Metamynodon</i>) and Cadurcodontini (<i>Procadurcodon</i>, <i>Zaisanamynodon</i>, <i>Cadurcodon</i> and <i>Cadurcotherium</i>). The remaining amynodontid genera are considered <i>incertae sedis</i>. The evolution of amynodontids was confined mainly to Central and East Asia, with four dispersal events to North America (<i>Amynodon</i>, <i>Amynodontopsis</i>, Metamynodontini and <i>Procadurcodon</i>), and one to Europe and South Asia (<i>Cadurcotherium</i>). The holotype of <i>C. maomingensis</i> sp. nov. is an adult male with body mass estimated as 1.4 tons. Amynodontids show considerable increase in size during evolution, with the largest species weighing over two tons (<i>C. kazakademius</i>, <i>Zaisanamynodon borisovi</i> and <i>Procadurcodon orientalis</i>). http://zoobank.org/urn:lsid:zoobank.org:pub:FD6EEE3E-AE06-4DA2-AFFD-39362724C1C2
DOI: 10.6084/m9.figshare.4286216.v1
title: vtc

description: vtc files
DOI: 10.6084/m9.figshare.4286255.v1
title: A new amynodontid from the Eocene of South China and phylogeny of Amynodontidae (Perissodactyla: Rhinocerotoidea)

description: <i>Cadurcodon maomingensis</i> sp. nov. is described based on a partial skull and associated vertebrae from the middle–upper Eocene Youganwo Formation in the Maoming Basin, Guangdong Province, China. The taxonomy of <i>Cadurcodon</i> Kretzoi, 1942 ( = <i>Sianodon</i> Xu, 1965, syn. nov.; = <i>Paracadurcodon</i> Xu, 1966, syn. nov.) is revised, and a new diagnosis of the genus is provided. It includes six species: <i>C. ardynensis</i> (Osborn, 1923), <i>C. kazakademius</i> Biryukov, 1961, <i>C. bahoensis</i> (Xu, 1965) comb. nov., <i>C. suhaituensis</i> (Xu, 1966) comb. nov., <i>C. houldjinensis</i> B.-Y. Wang, Qiu, Zhang, Wu, & Ning, 2009 and <i>C. maomingensis</i> sp. nov. A new phylogenetic hypothesis of Amynodontidae is based on the cladistic analysis of the distribution of 48 characters in 16 amynodontid taxa. The family is divided into two sister taxa, Metamynodontini (<i>Paramynodon</i>, <i>Megalamynodon</i> and <i>Metamynodon</i>) and Cadurcodontini (<i>Procadurcodon</i>, <i>Zaisanamynodon</i>, <i>Cadurcodon</i> and <i>Cadurcotherium</i>). The remaining amynodontid genera are considered <i>incertae sedis</i>. The evolution of amynodontids was confined mainly to Central and East Asia, with four dispersal events to North America (<i>Amynodon</i>, <i>Amynodontopsis</i>, Metamynodontini and <i>Procadurcodon</i>), and one to Europe and South Asia (<i>Cadurcotherium</i>). The holotype of <i>C. maomingensis</i> sp. nov. is an adult male with body mass estimated as 1.4 tons. Amynodontids show considerable increase in size during evolution, with the largest species weighing over two tons (<i>C. kazakademius</i>, <i>Zaisanamynodon borisovi</i> and <i>Procadurcodon orientalis</i>). http://zoobank.org/urn:lsid:zoobank.org:pub:FD6EEE3E-AE06-4DA2-AFFD-39362724C1C2
DOI: 10.6084/m9.figshare.4285979
title: Research Impact website

description: The School of Business and Economics (SBE) is committed to research which has a positive impact on the world outside academia. Our academics conduct excellent research in a wide range of topics in business, management, finance and economics
DOI: 10.6084/m9.figshare.4286003
title: SIMTEGR8

description: The purposes of the SIMTEGR8 project are to evaluate how emergency admissions to hospitals can be reduced andhelp improve the patient journey through new integrated interventions. The objectives of this study are to: 1. Evaluate the current interventions to identify the critical points (touchpoints, handoffs and failure demand) for the patient journey.2. Provide Innovation and testing of some new models of thinking and metrics that could be implemented to align transformation of health and social care related to patient journey experience.3. Influence policy nationally by building an evidence base and online application to inform the design of future service delivery. The 1-year project will form an important piece of work that will contribute to the ongoing evaluation of the impact of the Better Care Fund programme. A robust evaluation of the impact of new integrated care interventions on admissions to hospital will provide important evidence to inform the future health and care commissioning plans.
DOI: 10.6084/m9.figshare.4286003.v1
title: SIMTEGR8

description: The purposes of the SIMTEGR8 project are to evaluate how emergency admissions to hospitals can be reduced andhelp improve the patient journey through new integrated interventions. The objectives of this study are to: 1. Evaluate the current interventions to identify the critical points (touchpoints, handoffs and failure demand) for the patient journey.2. Provide Innovation and testing of some new models of thinking and metrics that could be implemented to align transformation of health and social care related to patient journey experience.3. Influence policy nationally by building an evidence base and online application to inform the design of future service delivery. The 1-year project will form an important piece of work that will contribute to the ongoing evaluation of the impact of the Better Care Fund programme. A robust evaluation of the impact of new integrated care interventions on admissions to hospital will provide important evidence to inform the future health and care commissioning plans.
DOI: 10.6084/m9.figshare.4285841
title: Interpretation and Performance Practice in Realizing Stockhausen’s <i>Studie II</i>

description: In the 1950s, using electronic devices to make music seemed a new paradigm for composers eager to remove the effects of interpretation on their relationship with their audience. The promise was that compositional ideas could be directly made into sound with the help of a technician whose task it was to carry out instructions. By making a new realization of Stockhausen’s <i>Studie II</i>, composed in 1954, I interrogate many of the original techniques and practices, and show that there are many sites which require interpretation and raise issues of performance practice. The implication of these discoveries is that there may be advantages to an analysis of early electronic music of the 1950s and 1960s from the perspective of the practice of instrumental music, and that where there are references to ‘technicians’, great care should be taken to understand and appreciate the range of musical skills often required by such individuals. This approach to realization also raises serious questions about the ontology of electronic music.
DOI: 10.6084/m9.figshare.4285979.v1
title: Research Impact website

description: The School of Business and Economics (SBE) is committed to research which has a positive impact on the world outside academia. Our academics conduct excellent research in a wide range of topics in business, management, finance and economics
DOI: 10.6084/m9.figshare.4285841.v1
title: Interpretation and Performance Practice in Realizing Stockhausen’s <i>Studie II</i>

description: In the 1950s, using electronic devices to make music seemed a new paradigm for composers eager to remove the effects of interpretation on their relationship with their audience. The promise was that compositional ideas could be directly made into sound with the help of a technician whose task it was to carry out instructions. By making a new realization of Stockhausen’s <i>Studie II</i>, composed in 1954, I interrogate many of the original techniques and practices, and show that there are many sites which require interpretation and raise issues of performance practice. The implication of these discoveries is that there may be advantages to an analysis of early electronic music of the 1950s and 1960s from the perspective of the practice of instrumental music, and that where there are references to ‘technicians’, great care should be taken to understand and appreciate the range of musical skills often required by such individuals. This approach to realization also raises serious questions about the ontology of electronic music.
DOI: 10.6084/m9.figshare.4285832
title: Kimuyu eta al. Data.csv

description: Eight years dung survey data in exclosure plots excluding different combinations of domestic and wild ungulates. Also included, rainfall data and tree density data
DOI: 10.6084/m9.figshare.4285778
title: Swimming activity of larval zebrafish after exposure to irritant chemicals and analgesics

description: Swimming activity of larval zebrafish after exposure to irritant chemicals and analgesia
DOI: 10.6084/m9.figshare.4285832.v1
title: Kimuyu eta al. Data.csv

description: Eight years dung survey data in exclosure plots excluding different combinations of domestic and wild ungulates. Also included, rainfall data and tree density data
DOI: 10.6084/m9.figshare.4285778.v1
title: raw data.xlsx

description: Swimming activity of larval zebrafish after exposure to irritant chemicals and analgesia
DOI: 10.6084/m9.figshare.4285778.v3
title: Swimming activity of larval zebrafish after exposure to irritant chemicals and analgesics

description: Swimming activity of larval zebrafish after exposure to irritant chemicals and analgesia
DOI: 10.6084/m9.figshare.4285778.v2
title: Swimming activity of larval zebrafish upon exposure to chemicals and analgesics

description: Swimming activity of larval zebrafish after exposure to irritant chemicals and analgesia
DOI: 10.6084/m9.figshare.4285658
title: README.txt

description: Description of the data files in this depository.
DOI: 10.6084/m9.figshare.4285520
title: DATA_EarlyAttentionalAdjustmentsAfterConflict

description: Data for all analyses described in paper in excell spreadsheet.
DOI: 10.6084/m9.figshare.4285340
title: Plant Genome Size Comparison

description: Visualisations of the sizes of various genomes compared to bread wheat. There exists several figures using the diameter as being proportional to the genome size and one where the area is proportional to the genome size.<br>
DOI: 10.6084/m9.figshare.4285337
title: Automatic Terms and Nouns from Semantic Web

description: Dataset of terms from the Semantic Web Domain. The terms have been extracted automatically from a corpus of the Semantic Web Journal and the Journal of Semantic Web
DOI: 10.6084/m9.figshare.4285307
title: Primate-specific oestrogen-responsive long non-coding RNAs regulate proliferation and viability of human breast cancer cells, Lipovich et al. Supplementary Table 5 (ALSO: Supp. Docs 6 - 11 follow; please see main text document for the numbers and names of all 11 ESMs)

description: Annotation and primate-specific gene structure features of estrogen-responsive lncRNAs.
DOI: 10.6084/m9.figshare.4285307.v1
title: Primate-specific oestrogen-responsive long non-coding RNAs regulate proliferation and viability of human breast cancer cells, Lipovich et al. Supplementary Table 5 (ALSO: Supp. Docs 6 - 11 follow; please see main text document for the numbers and names of all 11 ESMs)

description: Annotation and primate-specific gene structure features of estrogen-responsive lncRNAs.
DOI: 10.6084/m9.figshare.4285289
title: Supplementary Table 6 from Primate-specific oestrogen-responsive long non-coding RNAs regulate proliferation and viability of human breast cancer cells

description: Long non-coding RNAs (lncRNAs) are transcripts of a recently discovered class of genes which do not code for proteins. LncRNA genes are approximately as numerous as protein-coding genes in the human genome. However, comparatively little remains known about lncRNA functions. We globally interrogated changes in the lncRNA transcriptome of oestrogen receptor positive human breast cancer cells following treatment with oestrogen, and identified 127 oestrogen-responsive lncRNAs. Consistent with the emerging evidence that most human lncRNA genes lack homologues outside of primates, our evolutionary analysis revealed primate-specific lncRNAs downstream of oestrogen signalling. We demonstrate, using multiple functional assays to probe gain- and loss-of-function phenotypes in two oestrogen receptor positive human breast cancer cell lines, that two primate-specific oestrogen-responsive lncRNAs identified in this study (the oestrogen-repressed lncRNA BC041455, which reduces cell viability, and the oestrogen-induced lncRNA CR593775, which increases cell viability) exert previously unrecognized functions in cell proliferation and growth factor signalling pathways. The results suggest that oestrogen-responsive lncRNAs are capable of altering the proliferation and viability of human breast cancer cells. No effects on cellular phenotypes were associated with control transfections. As heretofore unappreciated components of key signalling pathways in cancers, including the MAP kinase pathway, lncRNAs hence represent a novel mechanism of action for oestrogen effects on cellular proliferation and viability phenotypes. This finding warrants further investigation in basic and translational studies of breast and potentially other types of cancers, has broad relevance to lncRNAs in other nuclear hormone receptor pathways, and should facilitate exploiting and targeting these cell viability modulating lncRNAs in post-genomic therapeutics.
DOI: 10.6084/m9.figshare.4285289.v1
title: Supplementary Table 6 from Primate-specific oestrogen-responsive long non-coding RNAs regulate proliferation and viability of human breast cancer cells

description: Long non-coding RNAs (lncRNAs) are transcripts of a recently discovered class of genes which do not code for proteins. LncRNA genes are approximately as numerous as protein-coding genes in the human genome. However, comparatively little remains known about lncRNA functions. We globally interrogated changes in the lncRNA transcriptome of oestrogen receptor positive human breast cancer cells following treatment with oestrogen, and identified 127 oestrogen-responsive lncRNAs. Consistent with the emerging evidence that most human lncRNA genes lack homologues outside of primates, our evolutionary analysis revealed primate-specific lncRNAs downstream of oestrogen signalling. We demonstrate, using multiple functional assays to probe gain- and loss-of-function phenotypes in two oestrogen receptor positive human breast cancer cell lines, that two primate-specific oestrogen-responsive lncRNAs identified in this study (the oestrogen-repressed lncRNA BC041455, which reduces cell viability, and the oestrogen-induced lncRNA CR593775, which increases cell viability) exert previously unrecognized functions in cell proliferation and growth factor signalling pathways. The results suggest that oestrogen-responsive lncRNAs are capable of altering the proliferation and viability of human breast cancer cells. No effects on cellular phenotypes were associated with control transfections. As heretofore unappreciated components of key signalling pathways in cancers, including the MAP kinase pathway, lncRNAs hence represent a novel mechanism of action for oestrogen effects on cellular proliferation and viability phenotypes. This finding warrants further investigation in basic and translational studies of breast and potentially other types of cancers, has broad relevance to lncRNAs in other nuclear hormone receptor pathways, and should facilitate exploiting and targeting these cell viability modulating lncRNAs in post-genomic therapeutics.