cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.12793736
title: Supplementary Material for: Genetics May Predict Effectiveness of Tolvaptan in Autosomal Dominant Polycystic Kidney Disease

description: <b><i>Background:</i></b> Tolvaptan is the only therapeutic drug for autosomal dominant polycystic kidney disease (ADPKD). The influence of mutations in polycystic kidney disease 1 and 2 genes (<i>PKD1</i> and <i>PKD2</i>) on the treatment effects of tolvaptan is not well documented in the literature. <b><i>Methods:</i></b> We retrospectively evaluated the relationship between genotype and the efficacy of tolvaptan in 18 patients with ADPKD who had been treated at Toranomon Hospital and undergone genetic testing between April 2016 and February 2020. <b><i>Results:</i></b> The annual change in estimated glomerular filtration rate (ΔeGFR/y) from before to after tolvaptan was from a median of −5.5 to −2.5 mL/min/1.73 m<sup>2</sup> in the <i>PKD1</i> truncating group, −3.3 to −2.4 mL/min/1.73 m<sup>2</sup> in the <i>PKD1</i> non-truncating group, −3.1 to −1.6 mL/min/1.73 m<sup>2</sup> in the <i>PKD2</i> group, and −1.9 to −2.6 mL/min/1.73 m<sup>2</sup> in the group with no <i>PKD1/2</i> mutation. The median degrees of improvement of ΔeGFR/y were 2.5 (45%), 0.4 (10%), 0.6 (28%), and −0.7 (−37%) mL/min/1.73 m<sup>2</sup>, respectively. Compared with the group of patients with any <i>PKD1</i>/<i>2</i> mutation, the group with no <i>PKD1</i>/<i>2</i> mutation showed significantly less improvement in ΔeGFR/y with tolvaptan (0.6 vs. −0.7 mL/min/1.73 m<sup>2</sup>, respectively; <i>p</i> = 0.01) and significantly less improvement in the annual rate of increase in total kidney volume (TKV) with tolvaptan (−6.7 vs. −1.1%, respectively; <i>p</i> = 0.02). <b><i>Conclusion:</i></b> Patients with ADPKD and no <i>PKD1</i>/<i>2</i> mutation showed less improvement in ΔeGFR/y and the annual rate of increase in TKV with tolvaptan. Detecting <i>PKD1</i>/<i>2</i> mutations may be useful for predicting the effectiveness of tolvaptan.
DOI: 10.6084/m9.figshare.12793736.v1
title: Supplementary Material for: Genetics May Predict Effectiveness of Tolvaptan in Autosomal Dominant Polycystic Kidney Disease

description: <b><i>Background:</i></b> Tolvaptan is the only therapeutic drug for autosomal dominant polycystic kidney disease (ADPKD). The influence of mutations in polycystic kidney disease 1 and 2 genes (<i>PKD1</i> and <i>PKD2</i>) on the treatment effects of tolvaptan is not well documented in the literature. <b><i>Methods:</i></b> We retrospectively evaluated the relationship between genotype and the efficacy of tolvaptan in 18 patients with ADPKD who had been treated at Toranomon Hospital and undergone genetic testing between April 2016 and February 2020. <b><i>Results:</i></b> The annual change in estimated glomerular filtration rate (ΔeGFR/y) from before to after tolvaptan was from a median of −5.5 to −2.5 mL/min/1.73 m<sup>2</sup> in the <i>PKD1</i> truncating group, −3.3 to −2.4 mL/min/1.73 m<sup>2</sup> in the <i>PKD1</i> non-truncating group, −3.1 to −1.6 mL/min/1.73 m<sup>2</sup> in the <i>PKD2</i> group, and −1.9 to −2.6 mL/min/1.73 m<sup>2</sup> in the group with no <i>PKD1/2</i> mutation. The median degrees of improvement of ΔeGFR/y were 2.5 (45%), 0.4 (10%), 0.6 (28%), and −0.7 (−37%) mL/min/1.73 m<sup>2</sup>, respectively. Compared with the group of patients with any <i>PKD1</i>/<i>2</i> mutation, the group with no <i>PKD1</i>/<i>2</i> mutation showed significantly less improvement in ΔeGFR/y with tolvaptan (0.6 vs. −0.7 mL/min/1.73 m<sup>2</sup>, respectively; <i>p</i> = 0.01) and significantly less improvement in the annual rate of increase in total kidney volume (TKV) with tolvaptan (−6.7 vs. −1.1%, respectively; <i>p</i> = 0.02). <b><i>Conclusion:</i></b> Patients with ADPKD and no <i>PKD1</i>/<i>2</i> mutation showed less improvement in ΔeGFR/y and the annual rate of increase in TKV with tolvaptan. Detecting <i>PKD1</i>/<i>2</i> mutations may be useful for predicting the effectiveness of tolvaptan.
DOI: 10.6084/m9.figshare.12793688
title: IFN-r.XLS

description: ifn-r,il-4.ellsa
DOI: 10.6084/m9.figshare.12793676
title: Supplementary Material for: Renal Functional Reserve Is Related to the Nondipping Phenotype and to the Exercise Heart Rate Response in Patients with Essential Hypertension and Preserved Renal Function

description: <b><i>Background:</i></b> Renal functional reserve (RFR), defined as the difference between stress and resting glomerular filtration rate (GFR), may constitute a diagnostic tool to identify patients at higher risk of developing acute kidney injury or chronic kidney disease. Blunted RFR has been demonstrated in early stages of hypertension and has been attributed to impaired vascular reactivity due to an overactive sympathetic nervous system (SNS). <b><i>Objective:</i></b> The purpose of this study was to investigate whether RFR correlates with other phenotypes expressing overactivity of the SNS in patients with essential hypertension and preserved renal function. <b><i>Methods:</i></b> Thirty-six patients with untreated essential hypertension and a GFR &gt;60 mL/min/1.73 m<sup>2</sup> were enrolled. The following parameters were measured: RFR, 24-h ambulatory blood pressure (BP) profile, a treadmill stress test, and an echocardiographic examination. Urine and venous samples were obtained at specific time points for the determination of clinical parameters, and both resting and stress GFR were calculated by using endogenous creatinine clearance for the measurement of RFR after an acute oral protein load (1 g/kg). <b><i>Results:</i></b> Twenty-one patients had a RFR &lt;30 mL/min/1.73 m<sup>2</sup> and 15 had a RFR above this cutoff. A nondipping pattern of 24-h BP was significantly more frequent in patients with low RFR (57.1 vs. 25.0%, <i>p</i> &lt; 0.05 for systolic BP and 52.3 vs. 10.0%, <i>p</i> &lt; 0.02 for diastolic BP). Moreover, patients with lower RFR values showed a blunted heart rate (HR) response to exercise during treadmill test (<i>r</i> = 0.439, <i>p</i> &lt; 0.05). None of the echocardiographic parameters differed between the two groups of patients. <b><i>Conclusions:</i></b> In hypertensive patients with preserved GFR, reduced RFR is related to nondipping BP phenotype as well as to attenuated exercise HR response. Overactivity of the SNS may be a common pathway. Since loss of RFR may represent a risk factor for acute or chronic kidney injury, hypertensive patients with blunted RFR might need a more careful renal follow-up.
DOI: 10.6084/m9.figshare.12793610
title: Supplemental Data 1

description: DSMZ and CCOS collections of the strain SW165
DOI: 10.6084/m9.figshare.12793616
title: Supplementary Material for: Plasma Exchange as an Initial Treatment for Severe Bleeding Induced by Acquired Factor V Deficiency: A Case Report and Mini Literature Review

description: Acquired factor V deficiency (AFVD) is a rare autoimmune bleeding disorder. Unlike acquired hemophilia, bypass therapies with recombinant activated factor VII and activated prothrombin complex concentrates are ineffective for severe bleeding due to AFVD. Although several treatment strategies have been attempted, a standard of care for severe hemorrhage induced by AFVD is lacking. Herein, we report a case of AFVD with severe bleeding that responded to plasma exchange (PE) combined with immunosuppression. We also reviewed previously reported AFVD cases with severe hemorrhage and suggest that PE may be an effective initial treatment for AFVD-induced severe hemorrhage.
DOI: 10.6084/m9.figshare.12793688.v1
title: IFN-r.XLS

description: ifn-r,il-4.ellsa
DOI: 10.6084/m9.figshare.12793595
title: Chromosome-level genome assembly of Poropuntius huangchuchieni

description: The genome annotation (genomic features, GFF) of <i>Poropuntius huangchuchieni</i>, <i>Poropuntius</i> genus, Barbinae subfamily, Cyprinid family.<br>
DOI: 10.6084/m9.figshare.12793676.v1
title: Supplementary Material for: Renal Functional Reserve Is Related to the Nondipping Phenotype and to the Exercise Heart Rate Response in Patients with Essential Hypertension and Preserved Renal Function

description: <b><i>Background:</i></b> Renal functional reserve (RFR), defined as the difference between stress and resting glomerular filtration rate (GFR), may constitute a diagnostic tool to identify patients at higher risk of developing acute kidney injury or chronic kidney disease. Blunted RFR has been demonstrated in early stages of hypertension and has been attributed to impaired vascular reactivity due to an overactive sympathetic nervous system (SNS). <b><i>Objective:</i></b> The purpose of this study was to investigate whether RFR correlates with other phenotypes expressing overactivity of the SNS in patients with essential hypertension and preserved renal function. <b><i>Methods:</i></b> Thirty-six patients with untreated essential hypertension and a GFR &gt;60 mL/min/1.73 m<sup>2</sup> were enrolled. The following parameters were measured: RFR, 24-h ambulatory blood pressure (BP) profile, a treadmill stress test, and an echocardiographic examination. Urine and venous samples were obtained at specific time points for the determination of clinical parameters, and both resting and stress GFR were calculated by using endogenous creatinine clearance for the measurement of RFR after an acute oral protein load (1 g/kg). <b><i>Results:</i></b> Twenty-one patients had a RFR &lt;30 mL/min/1.73 m<sup>2</sup> and 15 had a RFR above this cutoff. A nondipping pattern of 24-h BP was significantly more frequent in patients with low RFR (57.1 vs. 25.0%, <i>p</i> &lt; 0.05 for systolic BP and 52.3 vs. 10.0%, <i>p</i> &lt; 0.02 for diastolic BP). Moreover, patients with lower RFR values showed a blunted heart rate (HR) response to exercise during treadmill test (<i>r</i> = 0.439, <i>p</i> &lt; 0.05). None of the echocardiographic parameters differed between the two groups of patients. <b><i>Conclusions:</i></b> In hypertensive patients with preserved GFR, reduced RFR is related to nondipping BP phenotype as well as to attenuated exercise HR response. Overactivity of the SNS may be a common pathway. Since loss of RFR may represent a risk factor for acute or chronic kidney injury, hypertensive patients with blunted RFR might need a more careful renal follow-up.
DOI: 10.6084/m9.figshare.12793610.v1
title: Supplementary Data 1

description: DSMZ and CCOS collections of the strain SW165
DOI: 10.6084/m9.figshare.12793616.v1
title: Supplementary Material for: Plasma Exchange as an Initial Treatment for Severe Bleeding Induced by Acquired Factor V Deficiency: A Case Report and Mini Literature Review

description: Acquired factor V deficiency (AFVD) is a rare autoimmune bleeding disorder. Unlike acquired hemophilia, bypass therapies with recombinant activated factor VII and activated prothrombin complex concentrates are ineffective for severe bleeding due to AFVD. Although several treatment strategies have been attempted, a standard of care for severe hemorrhage induced by AFVD is lacking. Herein, we report a case of AFVD with severe bleeding that responded to plasma exchange (PE) combined with immunosuppression. We also reviewed previously reported AFVD cases with severe hemorrhage and suggest that PE may be an effective initial treatment for AFVD-induced severe hemorrhage.
DOI: 10.6084/m9.figshare.12793556
title: epidemiological_data.csv

description: This data includes daily confirmed cases during the first 190 days of COVID-19 by province in South Korea
DOI: 10.6084/m9.figshare.12793565
title: subway_ridership_hours.csv

description: This data compares hourly number of people getting on and off at subway stations using transportation cards in 2019 with those in 2020 for each corresponding day of week
DOI: 10.6084/m9.figshare.12793556.v1
title: epidemiological_data.csv

description: This data includes daily confirmed cases during the first 190 days of COVID-19 by province in South Korea
DOI: 10.6084/m9.figshare.12793559
title: traffic_volume_hours.csv

description: This data compares hourly traffic volume at 105 inbound and outbound count locations in 2019 with those in 2020 for corresponding day of week
DOI: 10.6084/m9.figshare.12793565.v1
title: subway_ridership_hours.csv

description: This data compares hourly number of people getting on and off at subway stations using transportation cards in 2019 with those in 2020 for each corresponding day of week
DOI: 10.6084/m9.figshare.12793526
title: SkotteChild

description: Accelerometry examples for the identification activity type using acceleration measured at the thigh and low back.
DOI: 10.6084/m9.figshare.12793532
title: Temporal alignment

description: Acceleration data used for developing an algorithm for the temporal alignment of acceleration measured with two independent activity monitors.
DOI: 10.6084/m9.figshare.12793544
title: Supplemental Table 1

description: Functional categories (COGs) from genome of strain SW165
DOI: 10.6084/m9.figshare.12793559.v1
title: traffic_volume_hours.csv

description: This data compares hourly traffic volume at 105 inbound and outbound count locations in 2019 with those in 2020 for corresponding day of week
DOI: 10.6084/m9.figshare.12793526.v1
title: SkotteChild

description: Accelerometry examples for the identification activity type using acceleration measured at the thigh and low back.
DOI: 10.6084/m9.figshare.12793532.v1
title: Temporal alignment

description: Acceleration data used for developing an algorithm for the temporal alignment of acceleration measured with two independent activity monitors.
DOI: 10.6084/m9.figshare.12793544.v1
title: Extended data

description: Functional categories (COGs) from genome of strain SW165
DOI: 10.6084/m9.figshare.12793475
title: Tasks items

description: Completed tasks
DOI: 10.6084/m9.figshare.12793508
title: Supplementary Material for: Environmental Interventions to Reduce the Consumption of Sugar-Sweetened Beverages: Abridged Cochrane Systematic Review

description: <b><i>Background:</i></b> Regular consumption of sugar-sweetened beverages (SSB) can increase the risk for obesity, type 2 diabetes, cardiovascular disease, and dental caries. Interventions that alter the physical or social environment in which individuals make beverage choices have been proposed to reduce the consumption of SSB. <b><i>Methods:</i></b> We included randomised controlled, non-randomised controlled, and interrupted time series studies on environmental interventions, with or without behavioural co-interventions, implemented in real-world settings, lasting at least 12 weeks, and including at least 40 individuals. Studies on the taxation of SSB were not included, as these are subject of a separate Cochrane review. We used standard Cochrane methods for data extraction, risk of bias assessment, and evidence grading and synthesis. Searches were updated to January 24, 2018. <b><i>Results:</i></b> We identified 14,488 unique records and assessed 1,030 full texts for eligibility. We included 58 studies comprising a total of 1,180,096 participants and a median length of follow-up of 10 months. We found moderate-certainty evidence for consistent associations with decreases in SSB consumption or sales for the following interventions: traffic light labelling, price increases on SSB, in-store promotion of healthier beverages in supermarkets, government food benefit programs with incentives for purchasing fruits and vegetables and restrictions on SSB purchases, multi-component community campaigns focused on SSB, and interventions improving the availability of low-calorie beverages in the home environment. For the remaining interventions we found low- to very-low-certainty evidence for associations showing varying degrees of consistency. <b><i>Conclusions:</i></b> With observed benefits outweighing observed harms, we suggest that environmental interventions to reduce the consumption of SSB be considered as part of a wider set of measures to improve population-level nutrition. Implementation should be accompanied by evaluations using appropriate methods. Future studies should examine population-level effects of interventions suitable for large-scale implementation, and interventions and settings not yet studied thoroughly.
DOI: 10.6084/m9.figshare.12793472
title: Supplementary Material for: Psychological Resilience as an Emergent Characteristic for Well-Being: A Pragmatic View

description: Currently, there is no clear agreement on the definition and conceptualization for psychological resilience (PR) in old age. Adopting a pragmatic view, this article elucidates the definition and conceptualization of PR by (1) extracting existing PR concepts that are relevant to aging, and (2) elucidating the contributing and delimiting factors for developing and sustaining PR as guided by the biopsychosocial framework. In addition, a comprehensive review of the tools used to measure PR was conducted to examine how scholars have conceptualized PR. Consequently, the renewed understanding defines PR as an emergent construct which is malleable, enduring, and can be developed and sustained by a dynamic interplay of biological, psychological, spiritual, and social factors. Correlates in terms of physical and mental well-being in the context of aging are identified.
DOI: 10.6084/m9.figshare.12793508.v1
title: Supplementary Material for: Environmental Interventions to Reduce the Consumption of Sugar-Sweetened Beverages: Abridged Cochrane Systematic Review

description: <b><i>Background:</i></b> Regular consumption of sugar-sweetened beverages (SSB) can increase the risk for obesity, type 2 diabetes, cardiovascular disease, and dental caries. Interventions that alter the physical or social environment in which individuals make beverage choices have been proposed to reduce the consumption of SSB. <b><i>Methods:</i></b> We included randomised controlled, non-randomised controlled, and interrupted time series studies on environmental interventions, with or without behavioural co-interventions, implemented in real-world settings, lasting at least 12 weeks, and including at least 40 individuals. Studies on the taxation of SSB were not included, as these are subject of a separate Cochrane review. We used standard Cochrane methods for data extraction, risk of bias assessment, and evidence grading and synthesis. Searches were updated to January 24, 2018. <b><i>Results:</i></b> We identified 14,488 unique records and assessed 1,030 full texts for eligibility. We included 58 studies comprising a total of 1,180,096 participants and a median length of follow-up of 10 months. We found moderate-certainty evidence for consistent associations with decreases in SSB consumption or sales for the following interventions: traffic light labelling, price increases on SSB, in-store promotion of healthier beverages in supermarkets, government food benefit programs with incentives for purchasing fruits and vegetables and restrictions on SSB purchases, multi-component community campaigns focused on SSB, and interventions improving the availability of low-calorie beverages in the home environment. For the remaining interventions we found low- to very-low-certainty evidence for associations showing varying degrees of consistency. <b><i>Conclusions:</i></b> With observed benefits outweighing observed harms, we suggest that environmental interventions to reduce the consumption of SSB be considered as part of a wider set of measures to improve population-level nutrition. Implementation should be accompanied by evaluations using appropriate methods. Future studies should examine population-level effects of interventions suitable for large-scale implementation, and interventions and settings not yet studied thoroughly.
DOI: 10.6084/m9.figshare.12793469
title: task.poi.rar

description: My prepared tasks.
DOI: 10.6084/m9.figshare.12793448
title: Supplementary Material for: HyperCKemia in Guillain-Barré Syndrome

description: The aim of the present study was to investigate the frequency and clinical features of Guillain-Barré syndrome (GBS) with hyperCKemia. We retrospectively identified 139 patients with GBS at 2 teaching hospitals in South Korea. We excluded patients with Miller-Fisher syndrome (<i>n</i> = 19), acute bulbar palsy (<i>n</i> = 3), and those whose serum creatine kinase (CK) levels were not measured (<i>n</i> = 45). Twelve of 72 patients (16.7%) had transient hyperCKemia, defined as serum CK ≥300 IU/L. The frequency of male sex and non-demyelinating electrodiagnostic features were higher in patients with hyperCKemia than those without. Transient hyperCKemia, occasionally seen in patients with GBS may be associated with the non-demyelinating subtype.
DOI: 10.6084/m9.figshare.12793475.v1
title: Tasks items

description: Completed tasks
DOI: 10.6084/m9.figshare.12793448.v1
title: Supplementary Material for: HyperCKemia in Guillain-Barré Syndrome

description: The aim of the present study was to investigate the frequency and clinical features of Guillain-Barré syndrome (GBS) with hyperCKemia. We retrospectively identified 139 patients with GBS at 2 teaching hospitals in South Korea. We excluded patients with Miller-Fisher syndrome (<i>n</i> = 19), acute bulbar palsy (<i>n</i> = 3), and those whose serum creatine kinase (CK) levels were not measured (<i>n</i> = 45). Twelve of 72 patients (16.7%) had transient hyperCKemia, defined as serum CK ≥300 IU/L. The frequency of male sex and non-demyelinating electrodiagnostic features were higher in patients with hyperCKemia than those without. Transient hyperCKemia, occasionally seen in patients with GBS may be associated with the non-demyelinating subtype.
DOI: 10.6084/m9.figshare.12793469.v2
title: task.poi.rar

description: My prepared tasks.
DOI: 10.6084/m9.figshare.12793475.v3
title: Tasks items

description: Completed tasks
DOI: 10.6084/m9.figshare.12793367
title: Pancreatic cancer cells (MIA) cocultured with multiple myeloma ctDNA

description: Whole genome sequencing data generated on pancreatic cells cocultured with circulating tumor DNA from a multiple myeloma patient.<br>The sequence underwent de novo assembly using SPADES 3.12.0This file is the contigs.fasta output from the SPADES assembly on the WGS data.
DOI: 10.6084/m9.figshare.12793475.v2
title: Tasks items

description: Completed tasks
DOI: 10.6084/m9.figshare.12793367.v1
title: Pancreatic cancer cells (MIA) cocultured with multiple myeloma ctDNA

description: Whole genome sequencing data generated on pancreatic cells cocultured with circulating tumor DNA from a multiple myeloma patient.<br>The sequence underwent de novo assembly using SPADES 3.12.0This file is the contigs.fasta output from the SPADES assembly on the WGS data.
DOI: 10.6084/m9.figshare.12793469.v1
title: task.poi.rar

description: My prepared tasks.
DOI: 10.6084/m9.figshare.12793193
title: Pancreatic cancer ctDNA

description: Whole genome sequencing data generated on circulating tumor DNA from a patient with Pancreatic cancer.The sequence underwent de novo assembly using SPADES 3.12.0This file is the contigs.fasta output from the SPADES assembly on the WGS data.
DOI: 10.6084/m9.figshare.12793250
title: Multiple Myeloma cells (MM1S) cocultured with pancreatic cancer ctDNA

description: Whole genome sequencing data generated on multiple myeloma cells cocultured with circulating tumor DNA from a pancreatic cancer patient.<br>The sequence underwent de novo assembly using SPADES 3.12.0This file is the contigs.fasta output from the SPADES assembly on the WGS data.
DOI: 10.6084/m9.figshare.12792896
title: Pancreatic cancer cell line (MIA)

description: Whole genome sequencing data generated on pancreatic cancer cell line.The sequence underwent de novo assembly using SPADES 3.12.0This file is the contigs.fasta output from the SPADES assembly on the WGS data.
DOI: 10.6084/m9.figshare.12792935
title: Multiple Myeloma ctDNA

description: Whole genome sequencing data generated on circulating tumor DNA from a multiple myeloma patient.The sequence underwent de novo assembly using SPADES 3.12.0This file is the contigs.fasta output from the SPADES assembly on the WGS data.