cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.17632/hr4y2pvy8b
title: Protective Effects of Hepatocyte Stress Defenders, Nrf1 and Nrf2, Against MASLD Progression

description: Background: Progression of metabolic dysfunction associated steatotic liver disease (MASLD) to steatohepatitis (MASH) is driven by stress-inducing lipids that promote liver inflammation and fibrosis, and MASH can lead to cirrhosis and hepatocellular carcinoma. Previously, we showed coordinated defenses regulated by transcription factors, nuclear factor erythroid 2 related fac-tor-1 (Nrf1) and -2 (Nrf2), protect against hepatic lipid stress. Here, we investigated protective effects of hepatocyte Nrf1 and Nrf2 against MASH-linked liver fibrosis and tumorigenesis.

Methods: Male and female mice with flox alleles for genes encoding Nrf1 (Nfe2l1), Nrf2 (Nfe2l2), or both were fed a MASH-inducing diet enriched with high fat, fructose, and cholesterol (HFFC) or control diet for 24-52 weeks. During this period, hepatocyte Nrf1, Nrf2, or combined deficien-cy for ~7-days, ~7-weeks, and ~35-weeks was induced by administering mice hepatocyte target-ing adeno-associated virus (AAV) expressing Cre recombinase. The effect on MASH, markers of liver fibrosis and proliferation, and liver tumorigenesis was compared to control mice receiving AAV expressing green fluorescent protein. Also, to assess the impact of Nrf1 and Nrf2 induction on liver fibrosis, HFFC diet fed C57bl/6J mice received weekly injections of carbon tetrachloride, and from week 16-24, mice were treated with Nrf2 activating drug bardoxolone, hepatocyte overexpression of human NRF1 (hNRF1), or both, and these groups were compared to control.

Results: Compared to control diet, 24-week feeding with HFFC diet increased bodyweight as well as liver weight, steatosis, and inflammation. It also increased hepatocyte proliferation and a marker of liver damage, p62. Hepatocyte Nrf1 and combined deficiency increased liver steatosis in control diet fed but not HFFC diet fed mice, and increased liver inflammation under both diet conditions. Hepatocyte Nrf1 deficiency also increased hepatocyte proliferation, whereas com-bined deficiency did not, and this also occurred for p62 level in control diet fed conditions. In 52-week HFFC diet fed mice, 35 weeks of hepatocyte Nrf1 deficiency, but not combined deficien-cy, resulted in more liver tumors in male mice, but not in female mice. In contrast, hepatocyte Nrf2 deficiency had no effect on any of these parameters. However, in the 15-week CCL4 exposed and 24-week HFFC diet fed mice, Nrf2 induction with bardoxolone reduced liver steatosis, inflam-mation, fibrosis, and proliferation. Induction of hepatic Nrf1 activity with hNRF1 enhanced the effect of bardoxolone on steatosis and may have stimulated liver progenitor cells.

Conclusion: Physiologic Nrf1 delays MASLD progression, Nrf2-induction alleviates MASH, and combined enhancement synergistically protects against steatosis and may facilitate liver re-pair.
DOI: 10.17632/8nry9w4pvf
title: University-Affiliated Hospitals: Clinical Practice, Education, or Research—Which Takes Precedence?

description: Question:
How do physicians in Chinese university-affiliated hospitals perceive the balance among clinical, teaching, and research responsibilities, and how does the current performance evaluation system impact their professional development?

Design, Setting, and Participants:
This cross-sectional survey study was conducted from May to December 2024 across 16 university-affiliated tertiary hospitals in 7 Chinese provinces. A nationally representative sample of 1,423 physicians completed validated questionnaires assessing their perceptions of clinical, teaching, and research tasks, as well as evaluations of the professional system.

Main outcomes:
Primary outcomes included physicians’ role prioritization, pressures associated with clinical workload, marginalization of teaching, and alienation of research due to quantitative evaluation metrics. 

The shared data include the original questionnaire and the raw data collected from it.
DOI: 10.17632/fypp49r6dk
title: HYPERDIRE HYPERgeometric functions DIfferential REduction: Mathematica-based packages for the differential reduction of generalized hypergeometric functions: Horn-type hypergeometric functions of two variables

description: This program has been imported from the CPC Program Library held at Queen's University Belfast (1969-2018) Abstract HYPERDIRE is a project devoted to the creation of a set of Mathematica-based programs for the differential reduction of hypergeometric functions. The current version allows for manipulations involving the full set of Horn-type hypergeometric functions of two variables, including 30 functions. Title of program: HYPERDIRE Catalogue Id: AEPP_v2_0 Nature of problem Reduction of Horn-type hypergeometric functions of two variables to a set of basis functions Versions of this program held in the CPC repository in Mendeley Data AEPP_v1_0; HYPERDIRE; 10.1016/j.cpc.2013.05.009 AEPP_v2_0; HYPERDIRE; 10.1016/j.cpc.2014.11.022 AEPP_v3_0; HYPERDIRE; 10.1016/j.cpc.2014.07.014 AEPP_v4_0; HYPERDIRE; 10.1016/j.cpc.2016.04.016
DOI: 10.17632/h8nbswgf95
title: Dataset_Barros_2021

description: Dataset of the manuscript entittled "Conservation of locomotion-induced oculomotor activity through evolution in higher tetrapods" by Filipa França de Barros, Julien Bacqué-Cazenave, Coralie Taillebuis, Gilles Courtand, Marin Manuel, Hélène Bras, Michele Tagliabue, Denis Combes , François Lambert, Mathieu Beraneck
DOI: 10.17632/j3hj7f9t67
title: Accompanying data to "On the intermittency of orographic gravity wave hotspots and its importance for middle atmosphere dynamics"

description: These datasets represent already preprocessed model and other data outputs in order to reproduce figures in the manuscript.
DOI: 10.6084/m9.figshare.12696455.v1
title: Supplementary Material for: Role of a Rare Variant in <b><i>APC</i></b> Gene Promoter 1B Region in Classic Familial Adenomatous Polyposis

description: <b><i>Background:</i></b> Familial adenomatous polyposis (FAP) is most commonly caused by germline variants in the adenomatous polyposis coli (<i>APC</i>) gene. Although definite pathogenic variants could be detected in the majority of individuals with FAP, there are still numerous variant-negative FAP patients. <b><i>Method:</i></b> We utilized a 139-gene next-generation sequencing (NGS) panel and multiplex ligation-dependent probe amplification (MLPA) to detect pathogenic variants in FAP patients and found a variant-negative pedigree. Through whole-exome sequencing (WES), we identified a point variant in the noncoding region in the <i>APC</i> gene. Finally, we used Sanger sequencing to analyze its pedigree cosegregation and a dual-luciferase reporter (DLR) assay to assess its function. <b><i>Results:</i></b> With the exception of 2 variants of undetermined significance (VUS), WES showed no pathogenic or likely pathogenic variants. After performing MLPA, the pedigree was still variant-negative. Interestingly, through WES, a point variant c.-190G&gt;A located in the promoter 1B region of the <i>APC</i> gene was identified in 3 affected individuals. Moreover, a variant carrier was found during screening of the family with Sanger sequencing. Through the DLR assay, we further confirmed that the variant c.-190G&gt;A caused significant suppression of downstream transcription of <i>APC</i>. <b><i>Conclusions:</i></b> The variant (c.-190G&gt;A) in the <i>APC</i> promoter 1B region is able to cause FAP with a classic phenotype, but this kind of variant in the noncoding region could be missed by conventional genetic testing. Thus, utilizing sequencing technologies covering a larger area can help us to further explore the pathogenesis in variant-negative FAP cases.
DOI: 10.6084/m9.figshare.11120891.v1
title: Surrogacy Transcript

description: This is a transcript.
DOI: 10.17632/8fp26vzw9w
title: DRO3

description: Debris propagation states for DRO3 orbit
DOI: 10.17632/smymkjcbxx
title: Field monitoring data on a residential exhaust air heat pump system (air to air heat pump)

description: Figure 1 (Fig1_Measurement_Setup) shows a hydraulic illustration of the investigated exhaust air heat pump (EHA-HP) and the position of the installed sensors. Air temperature and humidity on all four sides of the unit (outdoor air, extract air coming from the building, supply air to the building and exhaust air leaving the house) and electrical power consumption of the unit (compressor and ventilators) were measured and logged. The measurement period was 55 winter days with an interval of 1 second. In addition, the dynamic pressure difference (as an indication of the air volume rate) on the exhaust side was logged during the measurement period. Finally, the air volume rates of the unit at different ventilation levels was measured using Constant injection tracer gas method. Figure 2 (Fig2_summary_Vol_rates) summarizes the measured air volume rates and ventilators’ powers usage in different levels. The measurements were conducted in a KfW 55 efficient house with a living area of 235 m² near Stuttgart, Germany. The EHA-HP was installed in an air based hybrid heating system as the central heating source of the building. Figure 3 (Fig3_Applied_Sensors) gives an overview of the applied measurement methods and used sensors. Logging and conversion of signals were conducted using a modular I/O system; the fieldbus controller Ethernet 750-881 from WAGO Kontakttechnik.
DOI: 10.17632/r33995vfz6
title: Computer Modelling the Origins of Sexual Reproduction: Testing the Red Queen and Court Jester

description: Appendix
DOI: 10.4121/uuid:ce7e45cc-4711-4382-a2e9-1bbf59ede0ed
title: The concept of tradable peak credits, animated movies for a focus group study

description: Animated movies that were used to instruct participants about the concept of 'tradable peak credits' in a focus group study
DOI: 10.6084/m9.figshare.1528159.v1
title: Supplemental data - Phenolic Metabolites - Ounnas et al 2015 Plos One

description: Phenolic metabolites as detected in the urine of rats fed either a whole rye or a refined rye diet - as presented in Ounnas et al, Plos One, 2015
DOI: 10.17632/cc97k3pftw
title: Clinical outcomes of high-risk cutaneous squamous cell carcinomas treated with Mohs micrographic surgery alone: an analysis of local recurrence, regional nodal metastases, progression-free survival, and disease.

description: Clinical outcomes of high-risk cutaneous squamous cell carcinomas treated with Mohs micrographic surgery alone: an analysis of local recurrence, regional nodal metastases, progression-free survival, and disease.

Supplemental Table 1
Patient demographics and high-risk tumor characteristics

Supplemental Table 2
Multivariate Cox regression analysis demonstrating hazard ratios for high-risk tumor characteristics and associations with poor clinical outcomes. Statistically significant findings are highlighted in yellow.  

Supplemental Table 3
High-risk features associated with poor outcomes are presented as multivariate Cox proportional hazards models. Tumor features correlating with poor outcomes included size > 2cm, poor differentiation, and perineural invasion. Importantly, multivariate analysis demonstrated that poor differentiation was statistically significant for an increased risk of all poor outcomes – LR, NM, DM, and DSD. 

Supplemental Table 4
10-year cumulative incidence comparisons of local recurrence, nodal metastases and disease-specific death for high risk cSCC, stratified by AJCC and BWH stages, with our cohort compared to standardized historic published controls
DOI: 10.6084/m9.figshare.23498673.v1
title: Reporting guidelines

description: The data subset contains the following : CONSORT 2010 Checklist CONSORT Flow diagram
DOI: 10.17632/w2m5z28cck
title: Data for Determination of Trace Elemental Composition of CaCO3: Application to Mass Limited Abiogenic and Biogenic Carbonates.

description: ICP data for the paper Determination of Trace Elemental Composition of CaCO3: Application to Mass Limited Abiogenic and Biogenic Carbonates.
DOI: 10.6084/m9.figshare.19641303.v1
title: Antibiotic usage data of a commercial pig farm from 2016 to 2018 located in South Africa

description: The dataset was used for cost calculation for antibiotic usage and served as a numerator to quantify antibiotic usage according to the OIE in mg/kg. It is also used to quantify usage according to volume of use (kg).
DOI: 10.6084/m9.figshare.28436330.v2
title: Dataset: <b>Precise and accurate Ga isotope analysis of solution standards and geological reference materials by MC-ICP-MS</b>

description: <b>Table 1 </b>Elution scheme for separation of Ga from matrices in geological samples.<b>Table 2 </b>Operating parameters of the MC-ICP-MS (Neptune plus) during Ga isotope measurements.<b>Table 3 </b>Test of influences of matrix elements, acid molarity and concentration mismatch on Ga isotope analysis.<b>Table 4 </b>Gallium isotope compositions of geological reference materials reported in this study and literature.
DOI: 10.17632/9pxkynhr4w
title: Quantitative Data - Grammarly Questionnaire with Analysis

description: This questionnaire aims to examine EFL students’ attitudes toward teachers’ Grammarly deployment into writing classrooms. It also tests the following three null hypotheses:
H0: Students’ attitudes toward Grammarly deployment do not differ by gender.
H0: Students’ attitudes toward Grammarly deployment do not differ by students’ English proficiency level.
H0: Students’ attitudes toward Grammarly deployment do not differ by students’ institution types.
The statistical analysis reveals that all three hypotheses came to be true.
DOI: 10.17632/jcfjfh8ybk
title: Raw Data on Genetic Variants and Muscular Fitness in a Follow-Up Study of Middle-Aged and Older Adults

description: This dataset from a longitudinal study provides comprehensive anthropometric and physical fitness data from participants at baseline and 2.7 years later. It includes measurements of height (to the nearest 0.5 cm) and weight (to the nearest 0.1 kg) for calculating BMI. Physical fitness was assessed using isometric handgrip strength, lower body strength (30-second chair-stand test), functional mobility (timed up-and-go test), and aerobic endurance (6-minute walk test), all demonstrating acceptable reliability (ICC &gt; 0.7) within the Kosovo population. Additionally, genotypes were obtained from saliva samples, focusing on single nucleotide polymorphisms (SNPs) in the VDR (rs7975232, rs2228570, rs731236) and GC (rs4588, rs2282679) genes. Vitamin D status was determined exclusively at the follow-up measurements and analyzed for total 25-(OH)D levels using an enzyme-linked immunosorbent assay. This dataset enables the exploration of the impact of genetic variants on muscle fitness and vitamin D status in middle-aged and older adults in Kosovo.
DOI: 10.15468/dl.28ewqa
title: Occurrence Download

description: A dataset containing 10361 species occurrences available in GBIF matching the query:
{
 "and" : [
 "HasGeospatialIssue is false",
 "HasCoordinate is true",
 "OccurrenceStatus is Present",
 {
 "not" : {
 "BasisOfRecord" : [
 "is one of (Observation, Human Observation, Machine Observation, Living Specimen)"
 ]
 }
 },
 "TaxonKey is Lasioglossum pauxillum (Schenck, 1853)"
 ]
}

 The dataset includes 10361 records from 43 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0009311-250426092105405/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.17632/sw3jg5b3hx
title: Prevalence and risk factors for oral HPV in the healthy population

description: HPV prevalence in oral rinse and HPV-specific antibodies in peripheral blood were investigated in two groups of participants (mean age 23.2 and 55.7 years). Additionally, the risk factors for oral HPV infection and prevalence of HPV-specific antibodies were evaluated.
DOI: 10.17632/jpdpvtv3nc
title: Materials for: Language shapes children’s attitudes: Consequences of internal, behavioral, and societal information in punitive and non-punitive contexts

description: Materials for: Explanations shape children’s attitudes: Consequences of internal, behavioral, and societal explanations in punitive and non-punitive contexts
DOI: 10.17632/6rdxb8ydjp
title: Enquête climat scolaire au collège et au lycée

description: Questionnaire pour une enquête sur le climat scolaire au collège et au lycée.
DOI: 10.6084/m9.figshare.14014307.v1
title: Not just honeybees: predatory habits of <i>Vespa velutina</i> (Hymenoptera: Vespidae) in France

description: Understanding the impact of a predatory invasive alien species requires data on its diet. <i>Vespa velutina</i> Lepeletier, 1836, is a notorious bee-hawking hornet accidentally introduced in France before 2004 which spread across the European continent. Despite numerous studies and the impact on beekeeping activities, there are very few data on the diet of this species in its invaded range in Europe. To fill this knowledge gap, we studied 16 nests in the south-west of France between 2008 and 2010. Using a combination of morphological and barcoding approaches, we identified 2151 prey pellets showing that <i>V. velutina</i> acts as a generalist predator, preying on honeybees (38.1%), flies (29.9%) and social wasps (19.7%), as well as a wide spectrum of animal organisms (no less than 159 species identified). The prey spectrum is influenced by the nest surroundings, urban colonies preying more on honeybees and forest colonies preying more on social wasps. The predation intensity reaches its peak in early October. By comparing the dry weight of prey pellets to that of <i>V. velutina</i> larvae and considering the colony dynamics, we estimated that a single hornet nest can consume on average 11.32 kg of insect biomass in one season. Overall, our results suggest that <i>V. velutina</i> is a generalist opportunistic predator targeting mostly locally abundant prey. While the species may have an impact on honeybees, its generalist, opportunistic behaviour on abundant insects suggests a minor impact on wild species. Instead, attempts to manage this species using non-selective traps have a much greater impact on wild and domesticated entomofauna than the hornet itself.
DOI: 10.17632/8cp96syc42
title: Supplemental table 1

description: Diagnosis and procedure codes used to identify cases of basal cell carcinoma, procedure codes used to categorize repairs, and procedure codes used to identify emergency department visits
DOI: 10.21233/wacv-1338
title: Gamov Peninsula, Posyet Bay ostracode surface sample dataset

description: Raw data for the Gamov Peninsula, Posyet Bay ostracode surface sample dataset submitted to the Neotoma Paleoecology Database. Data is available through the landing page in JSON format. The landing page referenced by the DOI also contains links to publications and a map-based viewer for the dataset. The Neotoma Paleoecology Database maintains a homepage at https://www.neotomadb.org.
DOI: 10.17028/rd.lboro.7982006.v1
title: Dataset _ The influence of social context on the perception of assistive technology: Using a semantic differential scale to compare young adults’ views from the UK and Pakistan

description: This dataset contains raw data and their corresponding results files associated with a recent study. Each MS Excel spreadsheet entails the data for one aspect of study which is specified by name of the file.The information about participants i.e. personal and demographic, responses for first SD scale, second SD scale and personal evaluation are presented in each spreadsheet. The supplemental material (participant information sheet, informed consent form, online questionnaire, risk assessment form) are also enclosed with this dataset. Lastly, for the analysis of raw data, statistical test such as; independent sample t-test was performed. The original SPSS data files are also included.
DOI: 10.6084/m9.figshare.13238720.v4
title: Recovery of temporary pond alpha and beta diversity after wildfire disturbance: the role of dispersal and recolonization processes.

description: Wildfires are considered a world-wide disturbance which is currently being fostered by human-induced global changes. Their frequency and intensity are expected to increase in the near future in regions such as the Mediterranean basin. While terrestrial systems responses to wildfire have been thoroughly studied, aquatic systems such as temporary ponds have received less attention. Furthermore, previous works have focused on wildfire impacts in aquatics systems from a more functional and trait-based approach, but such disturbances can also impact these systems diversity at the local and regional level. In this work, we assess wildfire impacts in alpha and beta diversity of Mediterranean temporary ponds, analysing samples of pond macrofauna from before and after a wildfire that partially burned a set of temporary ponds. The wildfire did not change alpha-diversity patterns but differences in beta-diversity were observed when considering species abundance. Species with greater contribution to beta-diversity were more represented in Unburned ponds after the wildfire. These changes in species presence during the beginning of the hydroperiod increased Burned ponds regional differences (i.e., replacement increase). However, these alterations disappeared towards the middle and the end of the hydroperiod. Overall, we reported a fast recovery after the wildfire, tightly linked to a rapid recolonization that increased pond similarities. Landscape structure and ponds seasonal succession would have increased these systems resilience, but these key features against wildfire might become compromised due to global change scenarios (i.e., rise in wildfire regimes and habitat loss), representing a potential future threat to these highly diverse habitats. <br>
DOI: 10.6084/m9.figshare.14528727.v1
title: MVT9KD

description: MVT9KD provides auto-generated visual tags for over 9000 movie trailers. The movie IDs are in agreement with the movie IDs provided by "MovieLens (ML) dataset" (ML-20M or ML Latest Version). All the movie titles, ratings and associated movie genres and tags can be collected from the MovieLens website. We used the AWS Rekognition service to associate, celebrity, face and label tags to key frames from movie trailers and provide here the aggregated results.