cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.3404638
title: Modulation of spinal inhibitory reflexes depends on the frequency of transcutaneous electrical nerve stimulation in spastic stroke survivors

description: Neurophysiological studies in healthy subjects suggest that increased spinal inhibitory reflexes from the tibialis anterior (TA) muscle to the soleus (SOL) muscle might contribute to decreased spasticity. While 50 Hz is an effective frequency for transcutaneous electrical nerve stimulation (TENS) in healthy subjects, in stroke survivors, the effects of TENS on spinal reflex circuits and its appropriate frequency are not well known. We examined the effects of different frequencies of TENS on spinal inhibitory reflexes from the TA to SOL muscle in stroke survivors. Twenty chronic stroke survivors with ankle plantar flexor spasticity received 50-, 100-, or 200-Hz TENS over the deep peroneal nerve (DPN) of the affected lower limb for 30 min. Before and immediately after TENS, reciprocal Ia inhibition (RI) and presynaptic inhibition of the SOL alpha motor neuron (D1 inhibition) were assessed by adjusting the unconditioned H-reflex amplitude. Furthermore, during TENS, the time courses of spinal excitability and spinal inhibitory reflexes were assessed via the H-reflex, RI, and D1 inhibition. None of the TENS protocols affected mean RI, whereas D1 inhibition improved significantly following 200-Hz TENS. In a time-series comparison during TENS, repeated stimulation did not produce significant changes in the H-reflex, RI, or D1 inhibition regardless of frequency. These results suggest that the frequency-dependent effect of TENS on spinal reflexes only becomes apparent when RI and D1 inhibition are measured by adjusting the amplitude of the unconditioned H-reflex. However, 200-Hz TENS led to plasticity of synaptic transmission from the antagonist to spastic muscles in stroke survivors.
DOI: 10.6084/m9.figshare.3404638.v1
title: Modulation of spinal inhibitory reflexes depends on the frequency of transcutaneous electrical nerve stimulation in spastic stroke survivors

description: Neurophysiological studies in healthy subjects suggest that increased spinal inhibitory reflexes from the tibialis anterior (TA) muscle to the soleus (SOL) muscle might contribute to decreased spasticity. While 50 Hz is an effective frequency for transcutaneous electrical nerve stimulation (TENS) in healthy subjects, in stroke survivors, the effects of TENS on spinal reflex circuits and its appropriate frequency are not well known. We examined the effects of different frequencies of TENS on spinal inhibitory reflexes from the TA to SOL muscle in stroke survivors. Twenty chronic stroke survivors with ankle plantar flexor spasticity received 50-, 100-, or 200-Hz TENS over the deep peroneal nerve (DPN) of the affected lower limb for 30 min. Before and immediately after TENS, reciprocal Ia inhibition (RI) and presynaptic inhibition of the SOL alpha motor neuron (D1 inhibition) were assessed by adjusting the unconditioned H-reflex amplitude. Furthermore, during TENS, the time courses of spinal excitability and spinal inhibitory reflexes were assessed via the H-reflex, RI, and D1 inhibition. None of the TENS protocols affected mean RI, whereas D1 inhibition improved significantly following 200-Hz TENS. In a time-series comparison during TENS, repeated stimulation did not produce significant changes in the H-reflex, RI, or D1 inhibition regardless of frequency. These results suggest that the frequency-dependent effect of TENS on spinal reflexes only becomes apparent when RI and D1 inhibition are measured by adjusting the amplitude of the unconditioned H-reflex. However, 200-Hz TENS led to plasticity of synaptic transmission from the antagonist to spastic muscles in stroke survivors.
DOI: 10.6084/m9.figshare.3404632
title: Chronic subordination stress selectively downregulates the insulin signaling pathway in liver and skeletal muscle but not in adipose tissue of male mice

description: Chronic stress has been associated with obesity, glucose intolerance, and insulin resistance. We developed a model of chronic psychosocial stress (CPS) in which subordinate mice are vulnerable to obesity and the metabolic-like syndrome while dominant mice exhibit a healthy metabolic phenotype. Here we tested the hypothesis that the metabolic difference between subordinate and dominant mice is associated with changes in functional pathways relevant for insulin sensitivity, glucose and lipid homeostasis. Male mice were exposed to CPS for four weeks and fed either a standard diet or a high-fat diet (HFD). We first measured, by real-time PCR candidate genes, in the liver, skeletal muscle, and the perigonadal white adipose tissue (pWAT). Subsequently, we used a probabilistic analysis approach to analyze different ways in which signals can be transmitted across the pathways in each tissue. Results showed that subordinate mice displayed a drastic downregulation of the insulin pathway in liver and muscle, indicative of insulin resistance, already on standard diet. Conversely, pWAT showed molecular changes suggestive of facilitated fat deposition in an otherwise insulin-sensitive tissue. The molecular changes in subordinate mice fed a standard diet were greater compared to HFD-fed controls. Finally, dominant mice maintained a substantially normal metabolic and molecular phenotype even when fed a HFD. Overall, our data demonstrate that subordination stress is a potent stimulus for the downregulation of the insulin signaling pathway in liver and muscle and a major risk factor for the development of obesity, insulin resistance, and type 2 diabetes mellitus.
DOI: 10.6084/m9.figshare.3404632.v1
title: Chronic subordination stress selectively downregulates the insulin signaling pathway in liver and skeletal muscle but not in adipose tissue of male mice

description: Chronic stress has been associated with obesity, glucose intolerance, and insulin resistance. We developed a model of chronic psychosocial stress (CPS) in which subordinate mice are vulnerable to obesity and the metabolic-like syndrome while dominant mice exhibit a healthy metabolic phenotype. Here we tested the hypothesis that the metabolic difference between subordinate and dominant mice is associated with changes in functional pathways relevant for insulin sensitivity, glucose and lipid homeostasis. Male mice were exposed to CPS for four weeks and fed either a standard diet or a high-fat diet (HFD). We first measured, by real-time PCR candidate genes, in the liver, skeletal muscle, and the perigonadal white adipose tissue (pWAT). Subsequently, we used a probabilistic analysis approach to analyze different ways in which signals can be transmitted across the pathways in each tissue. Results showed that subordinate mice displayed a drastic downregulation of the insulin pathway in liver and muscle, indicative of insulin resistance, already on standard diet. Conversely, pWAT showed molecular changes suggestive of facilitated fat deposition in an otherwise insulin-sensitive tissue. The molecular changes in subordinate mice fed a standard diet were greater compared to HFD-fed controls. Finally, dominant mice maintained a substantially normal metabolic and molecular phenotype even when fed a HFD. Overall, our data demonstrate that subordination stress is a potent stimulus for the downregulation of the insulin signaling pathway in liver and muscle and a major risk factor for the development of obesity, insulin resistance, and type 2 diabetes mellitus.
DOI: 10.6084/m9.figshare.3404632.v3
title: Chronic subordination stress selectively downregulates the insulin signaling pathway in liver and skeletal muscle but not in adipose tissue of male mice

description: Chronic stress has been associated with obesity, glucose intolerance, and insulin resistance. We developed a model of chronic psychosocial stress (CPS) in which subordinate mice are vulnerable to obesity and the metabolic-like syndrome while dominant mice exhibit a healthy metabolic phenotype. Here we tested the hypothesis that the metabolic difference between subordinate and dominant mice is associated with changes in functional pathways relevant for insulin sensitivity, glucose and lipid homeostasis. Male mice were exposed to CPS for four weeks and fed either a standard diet or a high-fat diet (HFD). We first measured, by real-time PCR candidate genes, in the liver, skeletal muscle, and the perigonadal white adipose tissue (pWAT). Subsequently, we used a probabilistic analysis approach to analyze different ways in which signals can be transmitted across the pathways in each tissue. Results showed that subordinate mice displayed a drastic downregulation of the insulin pathway in liver and muscle, indicative of insulin resistance, already on standard diet. Conversely, pWAT showed molecular changes suggestive of facilitated fat deposition in an otherwise insulin-sensitive tissue. The molecular changes in subordinate mice fed a standard diet were greater compared to HFD-fed controls. Finally, dominant mice maintained a substantially normal metabolic and molecular phenotype even when fed a HFD. Overall, our data demonstrate that subordination stress is a potent stimulus for the downregulation of the insulin signaling pathway in liver and muscle and a major risk factor for the development of obesity, insulin resistance, and type 2 diabetes mellitus.
DOI: 10.6084/m9.figshare.3404632.v2
title: Chronic subordination stress selectively downregulates the insulin signaling pathway in liver and skeletal muscle but not in adipose tissue of male mice

description: Chronic stress has been associated with obesity, glucose intolerance, and insulin resistance. We developed a model of chronic psychosocial stress (CPS) in which subordinate mice are vulnerable to obesity and the metabolic-like syndrome while dominant mice exhibit a healthy metabolic phenotype. Here we tested the hypothesis that the metabolic difference between subordinate and dominant mice is associated with changes in functional pathways relevant for insulin sensitivity, glucose and lipid homeostasis. Male mice were exposed to CPS for four weeks and fed either a standard diet or a high-fat diet (HFD). We first measured, by real-time PCR candidate genes, in the liver, skeletal muscle, and the perigonadal white adipose tissue (pWAT). Subsequently, we used a probabilistic analysis approach to analyze different ways in which signals can be transmitted across the pathways in each tissue. Results showed that subordinate mice displayed a drastic downregulation of the insulin pathway in liver and muscle, indicative of insulin resistance, already on standard diet. Conversely, pWAT showed molecular changes suggestive of facilitated fat deposition in an otherwise insulin-sensitive tissue. The molecular changes in subordinate mice fed a standard diet were greater compared to HFD-fed controls. Finally, dominant mice maintained a substantially normal metabolic and molecular phenotype even when fed a HFD. Overall, our data demonstrate that subordination stress is a potent stimulus for the downregulation of the insulin signaling pathway in liver and muscle and a major risk factor for the development of obesity, insulin resistance, and type 2 diabetes mellitus.
DOI: 10.6084/m9.figshare.3404623
title: Targeting Holliday junctions by origin DNA-binding protein of herpes simplex virus type 1

description: In the present paper, the interactions of the origin binding protein (OBP) of herpes simplex virus type 1 (HSV1) with synthetic four-way Holliday junctions (HJs) were studied using electrophoresis mobility shift assay and the FRET method and compared with the interactions of the protein with duplex and single-stranded DNAs. It has been found that OBP exhibits a strong preference for binding to four-way and three-way DNA junctions and possesses much lower affinities to duplex and single-stranded DNAs. The protein forms three types of complexes with HJs. It forms complexes I and II which are reminiscent of the tetramer and octamer complexes with four-way junction of HJ-specific protein RuvA of <i>Escherichia coli</i>. The binding approaches saturation level when two OBP dimers are bound per junction. In the presence of Mg<sup>2+</sup> ions (≥2 mM) OBP also interacts with HJ in the stacked arm form (complex III). In the presence of 5 mM ATP and 10 mM Mg<sup>2+</sup> ions OBP catalyzes processing of the HJ in which one of the annealed oligonucleotides has a 3′-terminal tail containing 20 unpaired thymine residues. The observed preference of OBP for binding to the four-way DNA junctions provides a basis for suggestion that OBP induces large DNA structural changes upon binding to Box I and Box II sites in OriS. These changes involve the bending and partial melting of the DNA at A+T-rich spacer and also include the formation of HJ containing Box I and Box II inverted repeats and flanking DNA sequences.
DOI: 10.6084/m9.figshare.3404623.v1
title: Targeting Holliday junctions by origin DNA-binding protein of herpes simplex virus type 1

description: In the present paper, the interactions of the origin binding protein (OBP) of herpes simplex virus type 1 (HSV1) with synthetic four-way Holliday junctions (HJs) were studied using electrophoresis mobility shift assay and the FRET method and compared with the interactions of the protein with duplex and single-stranded DNAs. It has been found that OBP exhibits a strong preference for binding to four-way and three-way DNA junctions and possesses much lower affinities to duplex and single-stranded DNAs. The protein forms three types of complexes with HJs. It forms complexes I and II which are reminiscent of the tetramer and octamer complexes with four-way junction of HJ-specific protein RuvA of <i>Escherichia coli</i>. The binding approaches saturation level when two OBP dimers are bound per junction. In the presence of Mg<sup>2+</sup> ions (≥2 mM) OBP also interacts with HJ in the stacked arm form (complex III). In the presence of 5 mM ATP and 10 mM Mg<sup>2+</sup> ions OBP catalyzes processing of the HJ in which one of the annealed oligonucleotides has a 3′-terminal tail containing 20 unpaired thymine residues. The observed preference of OBP for binding to the four-way DNA junctions provides a basis for suggestion that OBP induces large DNA structural changes upon binding to Box I and Box II sites in OriS. These changes involve the bending and partial melting of the DNA at A+T-rich spacer and also include the formation of HJ containing Box I and Box II inverted repeats and flanking DNA sequences.
DOI: 10.6084/m9.figshare.3404596
title: carriers.csv

description: R Bootcamp Dataset
DOI: 10.6084/m9.figshare.3404596.v1
title: carriers.csv

description: R Bootcamp Dataset
DOI: 10.6084/m9.figshare.3403489
title: data from the dental CBCT imaging system ZCB100

description: <br> These datasets were obtained using the dental CBCT imaging system ZCB100 (Shenzhen ZhongKe TianYue Technology Co., Ltd.).
DOI: 10.6084/m9.figshare.3399220
title: Yuri Kriel - PLoS article 1 data.xlsx

description: NIRS (1sec), HR(1sec), mechanical power (1 sec) and VO2 (5sec) data from 12 participants completing three protocols involving 1) HIIT with passive recovery periods separating exercise bouts (PASS) 2) HIIT with active recovery periods separating exercise bouts (ACT) 3) ACT with HIIT bouts replaced with passive periods. <br>
DOI: 10.6084/m9.figshare.3399220.v1
title: Yuri Kriel - PLoS article 1 data.xlsx

description: NIRS (1sec), HR(1sec), mechanical power (1 sec) and VO2 (5sec) data from 12 participants completing three protocols involving 1) HIIT with passive recovery periods separating exercise bouts (PASS) 2) HIIT with active recovery periods separating exercise bouts (ACT) 3) ACT with HIIT bouts replaced with passive periods. <br>
DOI: 10.6084/m9.figshare.3399169
title: FocaLens dataset

description: This dataset is a simplified version of the FocaLens database.Since the online space is limited, we have to resize all the images to 480x320, which is the size of input image in our proposed model.<br>The full-size database will be published sooner.
DOI: 10.6084/m9.figshare.3399169.v1
title: FocaLens

description: This dataset is a simplified version of the FocaLens dataset.Since the online space is limited, we have to resize the images to 480x320, which is the size of input image in our proposed model.<br>The full size dataset will be published sooner.
DOI: 10.6084/m9.figshare.3399151
title: PD_plosONE_Paper_rawdata20150727.csv

description: The file include both genotype information of SNPs and the clinical information collected from subjects, including the Unified Parkinson's Disease Rating Scale and hte Hoehn-Yahr Stage information.
DOI: 10.6084/m9.figshare.3399151.v1
title: PD_plosONE_Paper_rawdata20150727.csv

description: The file include both genotype information of SNPs and the clinical information collected from subjects, including the Unified Parkinson's Disease Rating Scale and hte Hoehn-Yahr Stage information.
DOI: 10.6084/m9.figshare.3399088
title: Tutorial de solución de ecuaciones diferenciales ordinarias con forzamiento temporal estocástico

description: Tutorial para resolver una ecuación diferencial ordinaria, lineal y de primer orden, a la que se le aplican dos forzamientos temporales estocásticos. El primer forzamiento es un proceso centrado alrededor del origen con incrementos independientes distribuidos de manera uniforme. El segundo es un proceso con incrementos Gaussianos centrado en el origen (soluciones tipo Ornstein-Uhlenbeck).
DOI: 10.6084/m9.figshare.3399088.v1
title: Tutorial de solución de ecuaciones diferenciales ordinarias con forzamiento temporal estocástico

description: Tutorial para resolver una ecuación diferencial ordinaria, lineal y de primer orden, a la que se le aplican dos forzamientos temporales estocásticos. El primer forzamiento es un proceso centrado alrededor del origen con incrementos independientes distribuidos de manera uniforme. El segundo es un proceso con incrementos Gaussianos centrado en el origen (soluciones tipo Ornstein-Uhlenbeck).
DOI: 10.6084/m9.figshare.3399082
title: Tutorial de solución de ecuaciones diferenciales ordinarias con forzamiento temporal determinista

description: Tutorial para resolver una ecuación diferencial ordinaria a la que se le aplica un forzamiento temporal determinista (se verá el forzamiento con función alfa y con función seno).
DOI: 10.6084/m9.figshare.3399082.v1
title: Tutorial de solución de ecuaciones diferenciales ordinarias con forzamiento temporal determinista

description: Tutorial para resolver una ecuación diferencial ordinaria a la que se le aplica un forzamiento temporal determinista (se verá el forzamiento con función alfa y con función seno).
DOI: 10.6084/m9.figshare.3399079
title: Tutorial de solución de ecuaciones diferenciales ordinarias sujetas a una variación sistemática de parámetros

description: Se muestra cómo resolver una ecuación diferencial de primer grado variando parámetros sistemáticamente (condiciones iniciales y constante de tiempo).
DOI: 10.6084/m9.figshare.3399079.v1
title: Tutorial de solución de ecuaciones diferenciales ordinarias sujetas a una variación sistemática de parámetros

description: Se muestra cómo resolver una ecuación diferencial de primer grado variando parámetros sistemáticamente (condiciones iniciales y constante de tiempo).
DOI: 10.6084/m9.figshare.3399058
title: Tutorial de solución de ecuaciones diferenciales ordinarias con parámetros constantes en Python

description: Se muestra cómo resolver numéricamente una ecuación diferencial de primer grado y su comparación con la solución analítica.
DOI: 10.6084/m9.figshare.3399058.v3
title: Tutorial de solución de ecuaciones diferenciales ordinarias con parámetros constantes en Python

description: Se muestra cómo resolver numéricamente una ecuación diferencial de primer grado y su comparación con la solución analítica.
DOI: 10.6084/m9.figshare.3398899
title: Mutation rate variation or error supplementary code and data

description: Mutation rate variation or error supplementary code and data
DOI: 10.6084/m9.figshare.3398881
title: Master Dataset, ENSO Paper

description: This is the master dataset for the paper by Fisman, Tuite and Brown on ENSO effects on risk of inpatient infectious diseases in the United States. The dataset has been uploaded in Stata, R, Excel, CSV delimited, and Epi Info formats.<br>Outcomes are weighted estimates of zoonotic disease, fungal disease, pneumonia and influenza, vectorborne disease (subcategories tickborne and rickettsial disease, and arthropod borne viral disease) and enteric disease. Weighted admission counts are present for use as as model offsets.<br>Exposure measures are various ENSO indices, with the Multivariate El Nino Index (MEI) used in the base case. Other variables are US census region (indicator and categorical), year and month, and variables derived from year and month (e.g., year-squared, sine and cosine functions of year (fast Fourier transforms)).<br><br>
DOI: 10.6084/m9.figshare.3398881.v1
title: Master Dataset, ENSO Paper

description: This is the master dataset for the paper by Fisman, Tuite and Brown on ENSO effects on risk of inpatient infectious diseases in the United States. The dataset has been uploaded in Stata, R, Excel, CSV delimited, and Epi Info formats.<br>Outcomes are weighted estimates of zoonotic disease, fungal disease, pneumonia and influenza, vectorborne disease (subcategories tickborne and rickettsial disease, and arthropod borne viral disease) and enteric disease. Weighted admission counts are present for use as as model offsets.<br>Exposure measures are various ENSO indices, with the Multivariate El Nino Index (MEI) used in the base case. Other variables are US census region (indicator and categorical), year and month, and variables derived from year and month (e.g., year-squared, sine and cosine functions of year (fast Fourier transforms)).<br><br>
DOI: 10.6084/m9.figshare.3398797
title: BenchmarkDP - Format technology lifecycle analysis - figures used in the paper

description: This fileset contains all the figures from the paper <br>Format technology lifecycle analysis done in the BenchmarkDP project<br>
DOI: 10.6084/m9.figshare.3398797.v1
title: BenchmarkDP - Format technology lifecycle analysis - figures used in the paper

description: This fileset contains all the figures from the paper <br>Format technology lifecycle analysis done in the BenchmarkDP project<br>
DOI: 10.6084/m9.figshare.3398797.v2
title: BenchmarkDP - Format technology lifecycle analysis - figures used in the paper

description: This fileset contains all the figures from the paper <br>Format technology lifecycle analysis done in the BenchmarkDP project<br>
DOI: 10.6084/m9.figshare.3398797.v3
title: BenchmarkDP - Format technology lifecycle analysis - figures used in the paper

description: This fileset contains all the figures from the paper <br>Format technology lifecycle analysis done in the BenchmarkDP project<br>
DOI: 10.6084/m9.figshare.3398797.v4
title: BenchmarkDP - Format technology lifecycle analysis - figures used in the paper

description: This fileset contains all the figures from the paper <br>Format technology lifecycle analysis done in the BenchmarkDP project<br>
DOI: 10.6084/m9.figshare.3398797.v6
title: BenchmarkDP - Format technology lifecycle analysis - figures used in the paper

description: This fileset contains all the figures from the paper <br>Format technology lifecycle analysis done in the BenchmarkDP project<br>
DOI: 10.6084/m9.figshare.3398797.v5
title: BenchmarkDP - Format technology lifecycle analysis - figures used in the paper

description: This fileset contains all the figures from the paper <br>Format technology lifecycle analysis done in the BenchmarkDP project<br>