cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.25549/usctheses-c3-1674
title: DNA deamination and binding properties of wild type and HIGM2 mutants of activation induced cytidine daminase

description: AID is required for SHM and CSR as an initiator protein. Hyper IgM syndrome 2, a primary immunological deficiency disorder caused by AICDA gene (encoding AID) mutations, is characterized by severe decrease in CSR, which is often accompanied with more or less down-regulated SHM. ❧ Here we purified 23 missense AID HIGM2 mutants, which naturally occur in the human population and a few C terminus truncated mutants, one of which is a C-10 amino acid deletion and is known to only cause a defect in CSR but retains WT level or higher activity in SHM. ❧ All the mutants containing one single point mutation showed no detectable deamination activity on ssDNA substrate except for S43P, L98R, and R174S. Comparison of specific activity indicates that they are about 3, 26, 211 fold less active than WT AID respectively. Although these 3 mutants have reduced deamination specific activity, they have similar mutation spectrum to WT AID.  To the contrary ΔC15 and ΔC10 deletion mutants have about 2 fold increase in specific activity, whereas ΔC18 and ΔC17 have reduced specific activity. Sequence alignment indicates that helix 6 is a conserved structural feature of all APOBEC proteins. In agreement with this, a C terminus truncation of 19 or more amino acids disrupted the integrity of helix 6 of AID, resulting in the loss of deamination. ❧ Additionally DNA binding activity of some mutants was tested through rotational anisotropy and their dissociation constants were measured. Compared with WT AID R174S displayed 5 fold less binding affinity and the binding affinity of the ΔC10 is comparable to WT AID. Interestingly when we fit the data points from DNA binding by plotting the change in anisotropy as a function of enzyme concentration, we found that the ssDNA binding of WT AID fit better with cooperativity, which is abrogated in the case of C terminus deletion mutants, for which a rectangular hyperbolic curve is the best fit. ❧ Through the comparison of AID to some artificial mutants of APOBEC3G-CD2 domain of which the structure has been solved, the molecular mechanism of AID mutants and the relationship of structure and functions will be discussed.
DOI: 10.25549/usctheses-c17-804200
title: Studies on diamondoid hydrocarbons and their carbocations
DOI: 10.25549/usctheses-c3-160526
title: Page 8
DOI: 10.25549/usctheses-c3-177085
title: Page 90
DOI: 10.25549/usctheses-c3-158708
title: Be quiet: music outside of time

description: Be Quiet: Music Outside of Time reconsiders sound as a particle that exists in a micro-time scale where movement is negligible.  Examining the whisper performances of James Lee Byars and the sound clouds produced by composer Iannis Xenakis, this study demonstrates how grains of sound can be suspended indefinitely and positioned spatially to form acoustic territories.  As the voice reaches its zero point and sound approaches static form, music outside of time can be used to frame the duration of a performance beyond the capabilities of any performer, to perceptually enter a different time scale, or to create an acoustic territory that generously shapes social encounter. Byars’ The Perfect Whisper is to Nothing and Xenakis’ stochastic music demonstrate that sound is an object, a thing capable of delineating a territory, and that the aesthetic considerations for analyzing sound need no longer be concerned primarily with the way sound breaks time apart, but rather must examine the social formations that sound engenders.
DOI: 10.25549/usctheses-c3-160589
title: Page 71
DOI: 10.25549/usctheses-c3-321263
title: No-where and now-here: utopia and politics from Hegel to Deleuze

description: 2006 In this dissertation I investigate Gilles Deleuze’s anti-Hegelianism, arguing for its significance in understanding Deleuze (and Guattari’s) work as a whole and specifically its political implications. Deleuze and Guattari’s attempt to sidestep idealism and its historical working through of contradictions and differences brings them, I argue, close to the tradition of utopianism, which is characterized by subtraction, isolation, paradoxical reversibility, and the elision of the negative. In contrast, Hegel’s critique of autonomy, one-sidedness, and unreflected oppositions allows for a problematization of these characteristics of utopianism without sacrificing an emphatic notion of freedom and justice. ❧ The Deleuzian concepts of deterritorialization, flight, and difference are contrasted with the Hegelian concepts of Aufhebung, opposition, and mediation. Hegel’s emphasis on relation, struggle, and reconciliation through the concept and the labor of history is replaced by Deleuze with non-relational difference, detachment, and immanence. The proximity of such a thinking with the utopian imaginary is presented via a reading of classic utopian texts as well as theories of utopia put forth by Louis Marin, Fredric Jameson, Ernst Bloch, and others. Hegel’s treatment of the French Revolution in the Phenomenology of Spirit reveals his thinking of the political as a laborious negotiation between the particular and the universal. I analyze Deleuze and Guattari’s writings on capitalism in light of the utopian motif of affirming one side of a particular socio-historical trend accompanied by a repudiation of its other side. Where Hegel analyzes such dualities in terms of their mutual reciprocality, Deleuze and Guattari repeat the utopian gestures of affirmation and escape. The distance thereby created between the prosaic, actual world and an intensified, virtual one can be grasped as a space of invention; this utopian capacity is the strength of Deleuze and Guattari. It is Hegel however who provides the concepts for reflecting on and bridging the gap between the ideal and the real, without which political theory remains unable to think beyond the ideologically shaped desires of a particular historical moment.
DOI: 10.25549/usctheses-c3-160562
title: Page 44
DOI: 10.25549/usctheses-c3-170640
title: Page 130
DOI: 10.25549/usctheses-c3-209679
title: Euclidean extensions of dynamical systems

description: This thesis studies the special Euclidean group extension of discrete dynamical systems. Given a dynamical system (X, f), the extended dynamics is constructed as the pair (X×Γ, T) where Γ is the special Euclidean group and T is a map on this extended space. The special Euclidean  extension is viewed as an Rⁿ extension of a SO(n) extension of the base dynamics. ❧ After a review of dynamical systems theory, dynamical systems are classified based on whether they are periodic or chaotic. Chaos is defined as exponential mixing (equivalent to decay of correlations on observables). The behavior of typical trajectories in the extended dynamics are then analyzed for these classes of dynamical system. If the base dynamics is periodic, then typical trajectories on the extended space are bounded. For chaotic dynamics these trajectories are typically unbounded. ❧ Finally these results are numerically verified for various examples of dynamical systems. The plots of typical trajectories are shown for SE(2) extensions and the growth rates for various extensions are shown and the results discussed. Despite building a more complex map on a larger space (compared to the original dynamics) extensions of dynamical systems allow us to simplify detecting behavior that is difficult to show in the original dynamics.
DOI: 10.25549/usctheses-c3-205679
title: Characteristics of a social venture in higher education

description: Universities and colleges show increasing interest in internationalization due to accelerated interrelationships caused by the processes of globalization. With the business sector at the forefront of engagement in globalization, higher education institutions often mirror patterns found in the business sector rather than engaging in internationalization in ways that are aligned with their own values. As such, international partnerships in higher education also typically emulate the business sector through the creation of collaborations that focus on income generation (Altbach & Knight, 2007; Armstrong, 2007; Slaughter & Leslie, 1997) and prestige (Armstrong, 2007; Chan, 2004). Like partnerships in the business sector where competition produces inequitable relationships and cultural diversity is diminished through homogeneity, international partnerships in higher education often create similar conditions. ❧ This study examined the SINO-US Strategic Alliance (SUSTAIN), a unique international partnership in higher education that consciously strives to engage differently than typical partnerships in higher education. Using the business literature as a starting point, this study examined the nature and goals of this partnership, with particular attention to its organization as a social venture in higher education. The findings of this study examine SUSTAIN’s distinctive characteristics and the values of its participants, thereby identifying attributes associated with social ventures in higher education.
DOI: 10.25549/usctheses-c3-160590
title: Page 72
DOI: 10.25549/usctheses-c3-160581
title: Page 63
DOI: 10.25549/usctheses-c3-193948
title: The effect of tumor-mediated immune suppression on prostate cancer immunotherapy

description: Immunotherapy has long been proposed as a novel method of specifically, safely and inexpensively treating cancer. Despite decades of research and hundreds of clinical trials, only one therapeutic cancer vaccine has been approved for human use. The vast majority of these clinical trials have been carried out in terminally ill patients with advanced cancer. These patients are severely immune compromised. The studies herein demonstrate that multiple immunosuppressive mechanisms develop within prostate tumors as they progress. These mechanisms include the accumulation of regulatory T cells in the prostate tumor, and increased expression of TGFβ and indoleamine 2,3 dioxygenase in the prostate tumor. Vaccination of mice with spontaneously arising prostate cancer against tumor-associated antigens is vastly superior to immunization at later stages of disease, when tumor microenvironments are more suppressive. A novel murine model of prostate cancer in which major mediators of immune suppression – FOXP3-expressing regulatory T cells – can be specifically depleted was developed. This model was termed the TRAMP DEREG mouse. Depletion of regulatory T cells improved the response to therapeutic cancer vaccinination in TRAMP DEREG mice. This was the case even though Treg depletion was carried out at a phase of carcinogenesis prior to the development of serious immune suppression, suggesting that even better results can be obtained if Tregs are inhibited when they are most prevalent in immunosuppressive prostate tumors. Prostate cancer stem cells are responsible for driving tumor growth and regeneration. Additionally, they do not express the tumor-associated antigens that are targeted in prostate cancer immunotherapy, thus rendering them resistant to immune-medidated eradication. An effort was made to eliminate this population by inhibition of Notch signaling, but it was found that Notch signaling is not involved in the maintenance of the prostate cancer stem cell phenotype. In addition, Notch inhibition severely limited the efficacy of concomitant therapeutic cancer vaccination. However, the novel finding that Notch signaling is critical to the differentiation of prostate cancer cells, and thus to tumor growth and regeneration, is extremely important. Taken together, these studies show that immune-mediated tumor eradication is extremely difficult to achieve in advanced cancer. Therefore it is proposed that clinical trials of cancer immunotherapies be carried out in the preventative setting as soon as possible.
DOI: 10.25549/usctheses-c3-2056
title: Paying it forward: black men mentoring in a predominately latina/o community

description: Much of the literature on mentoring in disadvantaged communities focuses on the black middle class’s ability to mentor and role model for the black poor (Anderson 1999; DuBois [1899] 1967; Wilson 1987). William Julius Wilson (1987) noted that as middleclass blacks began to achieve, they moved from their previous African-American neighborhoods to the suburbs, leaving an impoverished underclass. Elijah Anderson (1999) describes “old heads” as mostly men who lived in low-income, African-American communities and had been able to obtain some economic markers of success who mentor young people. Anderson goes on to discuss how continued economic disenfranchisement has led to fewer “old heads” in the community. This dissertation examines the roles of African-American male coaches at a predominantly Latino recreation center in Los Angeles who take on the same role as Elijah Anderson’s “old heads.” The difference with these “old heads” is that, for them, community and the youth they mentor are not necessarily located where they live, but are at the recreation center where they congregate. Unlike much of the aforementioned work, these mentors or “Community Heads,” were raised as part of the working class or black poor and have limited educations. This study uses participant observation and interviews to examine a unique community site where new forms of cross-cultural mentorship occur and to challenge traditional top down approaches to studies of mentorship.
DOI: 10.25549/usctheses-c3-177074
title: Page 79
DOI: 10.25549/usctheses-c3-177102
title: Page 107
DOI: 10.25549/usctheses-c3-160569
title: Page 51
DOI: 10.25549/usctheses-c3-394080
title: Macroscopic and microscopic views of the contact angle
DOI: 10.25549/usctheses-c3-170641
title: Page 131
DOI: 10.25549/usctheses-c16-104081
title: Images of women and concepts of popular culture in Classical Athens: 450--400 B.C.
DOI: 10.25549/usctheses-c3-177093
title: Page 98
DOI: 10.25549/usctheses-c3-194704
title: Algorithmic aspects of energy efficient transmission in multihop cooperative wireless networks

description: We consider the problem of energy-efficient transmission in cooperative multihop wireless networks. Although the performance gains of cooperative approaches are well known, because of the combinatorial nature of these schemes, designing efficient polynomial-time algorithms to decide which nodes should take part in cooperation, and when and with what power they should transmit, has remained a challenge. We propose to tackle this problem in this dissertation. ❧ We provide a generalized algorithmic formulation of the problem that encompasses the two main cooperative approaches, namely: energy accumulation and mutual Information accumulation. We investigate the similarities and differences of these two approaches under our generalized formulation, focusing in particular on the scenario where a delay constraint is present.  We prove that the broadcast and multicast problems are, in general, o(log(n)) inapproximable. We break this NP hard problem into three parts: ordering, scheduling and power control and propose a generalized novel algorithm that, given an ordering, can optimally solve the joint power allocation and scheduling problems simultaneously in polynomial time. We further show empirically that this algorithm used in conjunction with an ordering derived heuristically using the Dijkstra's shortest path algorithm yields near-optimal performance in typical settings. In the unicast case, we prove that although the problem remains hard with mutual information accumulation, it can be solved optimally and in polynomial time when energy accumulation is used. We use our algorithm to study, numerically, the trade-off between delay and power-efficiency in cooperative broadcast and compare the performance of energy accumulation vs mutual information accumulation as well as the performance of our cooperative algorithm with a smart non-cooperative algorithm in a broadcast setting.  We also provide an O(Tlog²(n)) approximation algorithm for the broadcast case where energy accumulation is used. ❧ We further formulate the problem of minimum energy cooperative transmission in a delay constrained multiflow multihop wireless network, as a combinatorial optimization problem, for a general setting of k-flows and formally prove that the problem is not only NP-hard but it is o(n^{1/7-\epsilon}) inapproxmiable. To our knowledge, the results in this dissertation provides the first such inapproxmiablity proof in the context of multiflow cooperative wireless networks. We show that for a special case of k=1, the solution is a simple path and develop an optimal polynomial time algorithm for joint routing, scheduling and power control. We then use this algorithm to establish analytical upper and lower bounds for the optimal performance for the general case of k flows. Furthermore, we propose a polynomial time heuristic for calculating the solution for the general case and evaluate the performance of this heuristic under different channel conditions and against the analytical upper and lower bounds.
DOI: 10.25549/usctheses-c3-141473
title: Page 206
DOI: 10.25549/usctheses-c17-805765
title: Percolation porous media with long-range correlated heterogeneity
DOI: 10.25549/usctheses-c3-141459
title: Page 192
DOI: 10.25549/usctheses-c3-217182
title: Return engagement: contemporary art's traumas of modernity and history in diasporic Sai Gon and Phnom Penh

description: The dissertation examines modernity, popular culture and trauma in contemporary art in Asian America and Southeast Asia, with a focus on Việt Nam and Cambodia—two countries linked historically and regionally with each other and the United States. In addressing the dearth of art criticism on artists from the region, I argue that traumas such as military engagement and modernization return as thematic objects of desire and desired art objects on international art markets, however contested. I highlight artists tied to Phnom Penh and Sài Gòn, and challenge “diasporic” and “local” categorizations. Asian American artists living in Southeast Asia may be marketed—and identify—as “local.” Seasoned “local” Southeast Asian artists may have “diasporic” outlooks and practice flexible citizenship through their social networks, overseas residencies and exhibitions. In a competitive international art market, I assert that these artists strategically position themselves as both insiders and outsiders. For example, Sài Gòn returnees Tiffany Chung (Vietnamese American) and Sandrine Llouquet (Vietnamese French) embody and contest the gendered divides within “local/ non-local” communities. Meanwhile, Phnom Penh-based, U.S.-educated sculptor Sopheap Pich and Sài Gòn-based conceptual artist Phan Quang deal with urban-rural developments through different visual codes. For these artists, “translations” of local issues are (self-) exploitative gestures. ❧ Besides considering how artists deal with issues of marketing and location, I also question how artists of Southeast Asian descent are often expected to address the twin traumas of history and modernity. The breadth of visual culture in Asian America and Southeast Asia is explored through a range of visual art as well as documentary and experimental films. Return is a key theme across these media. For instance, the documentary films S-21: The Khmer Rouge Killing Machine and Refugee both feature protagonists returning to traumatic sites to confront figures from their pasts. The former film is directed by French Khmer Rithy Pahn whereas the latter is a collaborative project by Bay-area Japanese American filmmaker Spencer Nakasako and Cambodian American Mike Siv. Artistic framing, critical reception and varying audiences and contexts are analyzed in my project. Returning to historical archives, Cambodian collagist Leang Seckon and Vietnamese American experimental filmmaker Hồng-An Trương both use fragmentary approaches. They critique the spatial and temporal contradictions of modernizing projects. All of these cultural producers ambivalently grapple with violent pasts and the painful present.
DOI: 10.25549/usctheses-c17-804792
title: Performance analysis of asynchronous circuits and systems
DOI: 10.25549/usctheses-c17-807804
title: Economic analysis of financing an interstate highway system
DOI: 10.25549/usctheses-c17-804379
title: The stereochemical nature of the formation of pi-allylpalladium complexes from olefins
DOI: 10.25549/usctheses-c16-671806
title: Mozart's Viennese copyists
DOI: 10.25549/usctheses-c17-808654
title: Structure and evolution of mammalian interspersed repeats
DOI: 10.25549/usctheses-c17-805509
title: A three-dimensional structural analysis of the proximal third of the human femur
DOI: 10.25549/usctheses-c18-817119
title: A Comparison Of Educationally Related Opinions And Perceptions Of Community Organization Members With A Random Sample Of Voters
DOI: 10.25549/usctheses-c18-902030
title: Page 2784
DOI: 10.25549/usctheses-c17-807002
title: The estimation of roadway behavior using occupancy detectors
DOI: 10.25549/usctheses-c18-904813
title: A History Of Roman Catholic Church Policies..., p. 2777
DOI: 10.25549/usctheses-c17-806658
title: Villancicos and other secular polyphonic music of Juan Vasquez:  a courtly tradition in Spain's Siglo del Oro
DOI: 10.25549/usctheses-c18-904735
title: A History Of Roman Catholic Church Policies..., p. 2699
DOI: 10.25549/usctheses-c18-625392
title: Innovations In School Business Administration
DOI: 10.25549/usctheses-c18-901988
title: Page 2742
DOI: 10.25549/usctheses-c17-805023
title: Optimization of displacement efficiency of oil recovery in porous media using optimal control theory
DOI: 10.25549/usctheses-c18-901962
title: Page 2716
DOI: 10.25549/usctheses-c18-904738
title: A History Of Roman Catholic Church Policies..., p. 2702
DOI: 10.15151/esrf-es-116934142
title: UNRAVELLING RARE EARTH ELEMENTS (REE) MOBILITY IN PHOSPHOGYPSUM: ENVIRONMENTAL AND ECONOMIC IMPLICATIONS
DOI: 10.25549/usctheses-c18-904820
title: A History Of Roman Catholic Church Policies..., p. 2784
DOI: 10.25549/usctheses-c17-90
title: Integration of Biblically centered principles during reading, science, and social studies at fundamental Christian schools

description: This study focused on the need for fundamental Christian schools to integrate course curriculum with Biblical principles. In order to fully understand the nature of the study it is necessary to understand what is meant by the term "integration." In this regard, it can be noted that the word integration comes from the Latin word "integraie" meaning to make whole (Hopkins, 1937).
DOI: 10.25549/usctheses-c18-901984
title: Page 2738
DOI: 10.25549/usctheses-c18-484266
title: Attitudes Toward Drug Abuse And The Role Of The Secondary School
DOI: 10.25549/usctheses-c18-904757
title: A History Of Roman Catholic Church Policies..., p. 2721
DOI: 10.25549/usctheses-c18-902001
title: Page 2755
DOI: 10.25549/usctheses-c18-676703
title: Cross-Cultural Awareness And Attitudes Of Sixth-Grade American Children Attending United States Dependents Schools, European Area
DOI: 10.25549/usctheses-c18-901981
title: Page 2735
DOI: 10.25549/usctheses-c18-902012
title: Page 2766
DOI: 10.25549/usctheses-c18-901947
title: Page 2701
DOI: 10.25549/usctheses-c18-901985
title: Page 2739
DOI: 10.25549/usctheses-c18-901961
title: Page 2715
DOI: 10.25549/usctheses-c18-902031
title: Page 2785
DOI: 10.25549/usctheses-c18-901980
title: Page 2734
DOI: 10.25549/usctheses-c18-901995
title: Page 2749
DOI: 10.25549/usctheses-c18-901972
title: Page 2726
DOI: 10.25549/usctheses-c18-901992
title: Page 2746
DOI: 10.25549/usctheses-c18-901943
title: Page 2697
DOI: 10.25549/usctheses-c18-901957
title: Page 2711
DOI: 10.25549/usctheses-c18-901953
title: Page 2707
DOI: 10.25549/usctheses-c18-904785
title: A History Of Roman Catholic Church Policies..., p. 2749
DOI: 10.25549/usctheses-c18-901971
title: Page 2725
DOI: 10.25549/usctheses-c17-804581
title: Stochastic control of uncertain pharmacodynamic processes
DOI: 10.25549/usctheses-c18-904737
title: A History Of Roman Catholic Church Policies..., p. 2701
DOI: 10.25549/usctheses-c18-904805
title: A History Of Roman Catholic Church Policies..., p. 2769