cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.21382865.v1
title: Additional file 1 of Gossypetin ameliorates 5xFAD spatial learning and memory through enhanced phagocytosis against Aβ

description: Additional file 1. GOBP terms affected by gossypetin in 5xFAD. List of GOBP terms affected by gossypetin treatment in each 5xFAD microglial subpopulation.
DOI: 10.6084/m9.figshare.21382868
title: Additional file 2 of Gossypetin ameliorates 5xFAD spatial learning and memory through enhanced phagocytosis against Aβ

description: Additional file 2. DEGs between vehicle treated 5xFAD and WT. List of DEGs between WT and 5xFAD homeostatic microglia, stage 1, and stage 2 DAM subpopulations in hippocampus and cortex.
DOI: 10.6084/m9.figshare.21382868.v1
title: Additional file 2 of Gossypetin ameliorates 5xFAD spatial learning and memory through enhanced phagocytosis against Aβ

description: Additional file 2. DEGs between vehicle treated 5xFAD and WT. List of DEGs between WT and 5xFAD homeostatic microglia, stage 1, and stage 2 DAM subpopulations in hippocampus and cortex.
DOI: 10.6084/m9.figshare.21382871
title: Additional file 3 of Gossypetin ameliorates 5xFAD spatial learning and memory through enhanced phagocytosis against Aβ

description: Additional file 3. DEGs between 5xFAD vehicle and gossypetin treated group. Lists of DEGs between vehicle and gossypetin treated 5xFAD homeostatic microglia, stage 1, and stage 2 DAM subpopulation in hippocampus and cortex.
DOI: 10.6084/m9.figshare.21382871.v1
title: Additional file 3 of Gossypetin ameliorates 5xFAD spatial learning and memory through enhanced phagocytosis against Aβ

description: Additional file 3. DEGs between 5xFAD vehicle and gossypetin treated group. Lists of DEGs between vehicle and gossypetin treated 5xFAD homeostatic microglia, stage 1, and stage 2 DAM subpopulation in hippocampus and cortex.
DOI: 10.6084/m9.figshare.21382880
title: Additional file 2 of PredictCBC-2.0: a contralateral breast cancer risk prediction model developed and validated in ~ 200,000 patients

description: Additional file 2: Table S1. Description of the studies included in the analyses.
DOI: 10.6084/m9.figshare.21382880.v1
title: Additional file 2 of PredictCBC-2.0: a contralateral breast cancer risk prediction model developed and validated in ~ 200,000 patients

description: Additional file 2: Table S1. Description of the studies included in the analyses.
DOI: 10.6084/m9.figshare.21382883
title: Additional file 3 of PredictCBC-2.0: a contralateral breast cancer risk prediction model developed and validated in ~ 200,000 patients

description: Additional file 1: Table S3. Patient and primary breast cancer characteristics per study.
DOI: 10.6084/m9.figshare.21382883.v1
title: Additional file 3 of PredictCBC-2.0: a contralateral breast cancer risk prediction model developed and validated in ~ 200,000 patients

description: Additional file 1: Table S3. Patient and primary breast cancer characteristics per study.
DOI: 10.6084/m9.figshare.21382875
title: Acute Effects of Energy Drink on Autonomic and Cardiovascular Parameters Recovery in Individuals with Different Cardiorespiratory Fitness: A Randomized, Crossover, Double-Blind and Placebo-Controlled Trial

description: Abstract Background It has been suggested that the consumption of energy drinks (ED) may affect cardiovascular activity. Objectives to investigate the acute effects of ED intake on heart rate variability (HRV) and cardiovascular recovery after moderate aerobic exercise in males with different cardiorespiratory capacities. Methods This is a randomized, double-blind, crossover, placebo-controlled study. Twenty-eight young adults were split into two groups according to their peak oxygen consumption (VO2peak) values: (1) High VO2 peak (HO) - VO2 peak &gt; 52.15 mL/kg/min, and (2) low VO2 peak (LO) - peak VO2 &lt;52.15 mL/kg/min. Subjects of both groups underwent two exercise protocols in randomized order: moderate aerobic exercise (60% of VO2peak) following the intake of 250 mL of water (placebo protocol) or 250 mL of ED (ED protocol). During the exercise tests, values of cardiorespiratory and HRV parameters were recorded. Results Significant differences were observed for the LF (normalized units) index between rest and Rec1 in HO energy and LO groups during the ED protocol. For the LF/HF ratio, significant differences were seen between rest and Rec1 in HO and LO during ED protocols. Conclusion Acute ED intake delayed heart rate recovery after exercise in subjects with low and high cardiorespiratory fitness.
DOI: 10.6084/m9.figshare.21382875.v1
title: Acute Effects of Energy Drink on Autonomic and Cardiovascular Parameters Recovery in Individuals with Different Cardiorespiratory Fitness: A Randomized, Crossover, Double-Blind and Placebo-Controlled Trial

description: Abstract Background It has been suggested that the consumption of energy drinks (ED) may affect cardiovascular activity. Objectives to investigate the acute effects of ED intake on heart rate variability (HRV) and cardiovascular recovery after moderate aerobic exercise in males with different cardiorespiratory capacities. Methods This is a randomized, double-blind, crossover, placebo-controlled study. Twenty-eight young adults were split into two groups according to their peak oxygen consumption (VO2peak) values: (1) High VO2 peak (HO) - VO2 peak &gt; 52.15 mL/kg/min, and (2) low VO2 peak (LO) - peak VO2 &lt;52.15 mL/kg/min. Subjects of both groups underwent two exercise protocols in randomized order: moderate aerobic exercise (60% of VO2peak) following the intake of 250 mL of water (placebo protocol) or 250 mL of ED (ED protocol). During the exercise tests, values of cardiorespiratory and HRV parameters were recorded. Results Significant differences were observed for the LF (normalized units) index between rest and Rec1 in HO energy and LO groups during the ED protocol. For the LF/HF ratio, significant differences were seen between rest and Rec1 in HO and LO during ED protocols. Conclusion Acute ED intake delayed heart rate recovery after exercise in subjects with low and high cardiorespiratory fitness.
DOI: 10.6084/m9.figshare.14277399
title: Drug-Resistant Mycobacterium tuberculosis Isolates from New and Previously Treated TB Patients in China, 2017-2019

description: Abstract INTRODUCTION: Mycobacterium tuberculosis (MTB) is a causative agent of tuberculosis (TB) that causes death worldwide. METHODS: MTB was subjected to phenotypic drug-susceptibility tests (DST), and drug-resistant genes were sequenced. RESULTS: Previously treated patients were more likely to have positive smear results and exhibit drug resistance. New patients were more likely to be mono SM-resistant and less likely to be INH- and RIF-resistant. The most common mutations were katG (S315T), rpoB (S450L), rpsL (K43R), and embB (M306V). CONCLUSIONS: The proportion of mono-SM-resistant TB among new patients was higher.
DOI: 10.6084/m9.figshare.14277399.v1
title: Drug-Resistant Mycobacterium tuberculosis Isolates from New and Previously Treated TB Patients in China, 2017-2019

description: Abstract INTRODUCTION: Mycobacterium tuberculosis (MTB) is a causative agent of tuberculosis (TB) that causes death worldwide. METHODS: MTB was subjected to phenotypic drug-susceptibility tests (DST), and drug-resistant genes were sequenced. RESULTS: Previously treated patients were more likely to have positive smear results and exhibit drug resistance. New patients were more likely to be mono SM-resistant and less likely to be INH- and RIF-resistant. The most common mutations were katG (S315T), rpoB (S450L), rpsL (K43R), and embB (M306V). CONCLUSIONS: The proportion of mono-SM-resistant TB among new patients was higher.
DOI: 10.6084/m9.figshare.21382966
title: Additional file 1 of Tick microbial associations at the crossroad of horizontal and vertical transmission pathways

description: Additional file 1: Table S1. Details on studied forest sites. Table S2. The qPCR protocol for detection of tick symbionts and pathogens. Table S3. Bacterial loads of samples for the 16S rRNA sequencing; sample scheme. Table S4. Details on a positive control, primers, protocol, and in silico analysis used in the 16S rRNA quantification analyses. Table S5. OTU table. Table S6. Prevalence of veritcally and horizontally transmitted symbionts and pathogens per location. Table S7. Expected and observed co-infections in questing nymphs and results of the exact binomial test. Table S8. Tick microorganism species-to-species associations (co-infections) in ticks.
DOI: 10.6084/m9.figshare.21382966.v1
title: Additional file 1 of Tick microbial associations at the crossroad of horizontal and vertical transmission pathways

description: Additional file 1: Table S1. Details on studied forest sites. Table S2. The qPCR protocol for detection of tick symbionts and pathogens. Table S3. Bacterial loads of samples for the 16S rRNA sequencing; sample scheme. Table S4. Details on a positive control, primers, protocol, and in silico analysis used in the 16S rRNA quantification analyses. Table S5. OTU table. Table S6. Prevalence of veritcally and horizontally transmitted symbionts and pathogens per location. Table S7. Expected and observed co-infections in questing nymphs and results of the exact binomial test. Table S8. Tick microorganism species-to-species associations (co-infections) in ticks.
DOI: 10.6084/m9.figshare.21201102
title: Determination of SOD in black ginger extract and its effect on the liver of rats with type 2 diabetes

description: Abstract The peeling process of fresh ginger during factory production causes not only waste but also pollution to the environment. Now, by fermenting whole pieces of fresh ginger into black ginger, people are able to further enhance the nutritional value of ginger while lowering the burden on the environment. In this experiment, fresh ginger was fermented into black ginger, and superoxide dismutase (SOD) crudely extracted from both fresh ginger and black ginger were gavaged separately in type 2 diabetic rats to compare the SOD activity and effect in rat liver during the treatment of type 2 diabetes. It was found that the SOD activity of extracts from fermented black ginger was much higher than that of extracts from fresh ginger. In addition, the activity of SOD in the liver of rats gavaged with black ginger extract is higher than that in the liver of rats gavaged with fresh ginger extract, which shows that black ginger extract has certain protective effects on the liver.
DOI: 10.6084/m9.figshare.21201102.v1
title: Determination of SOD in black ginger extract and its effect on the liver of rats with type 2 diabetes

description: Abstract The peeling process of fresh ginger during factory production causes not only waste but also pollution to the environment. Now, by fermenting whole pieces of fresh ginger into black ginger, people are able to further enhance the nutritional value of ginger while lowering the burden on the environment. In this experiment, fresh ginger was fermented into black ginger, and superoxide dismutase (SOD) crudely extracted from both fresh ginger and black ginger were gavaged separately in type 2 diabetic rats to compare the SOD activity and effect in rat liver during the treatment of type 2 diabetes. It was found that the SOD activity of extracts from fermented black ginger was much higher than that of extracts from fresh ginger. In addition, the activity of SOD in the liver of rats gavaged with black ginger extract is higher than that in the liver of rats gavaged with fresh ginger extract, which shows that black ginger extract has certain protective effects on the liver.
DOI: 10.6084/m9.figshare.21382990
title: Additional file 2 of Specific metabolites drive the deterministic assembly of diseased rhizosphere microbiome through weakening microbial degradation of autotoxin

description: Additional file 2: Supplementary Table 1. Sampling information for diseased and healthy rhizosphere soils. Supplementary Table 2. Basic sequencing data for other reports integrated into our study. Supplementary Table 3. Soil chemical properties of the two soils used for the conditioned soil experiment. Supplementary Table 4. Selected different threshold (thresholda/b: represent selected the metabolites with the relative abundance greater/less than threshold for model 1/model2 construction) for model construction. Supplementary Table 5. Grouping of metabolites according to their chemical properties. Supplementary Table 6. Pairwise Adonis for multiple pairwise comparisons of rhizosphere metabolites. Supplementary Table 7. Total of 46 metabolites were significant difference and also in the best biomarkers identified by the random forest classifier between the two groups.
DOI: 10.6084/m9.figshare.21382990.v1
title: Additional file 2 of Specific metabolites drive the deterministic assembly of diseased rhizosphere microbiome through weakening microbial degradation of autotoxin

description: Additional file 2: Supplementary Table 1. Sampling information for diseased and healthy rhizosphere soils. Supplementary Table 2. Basic sequencing data for other reports integrated into our study. Supplementary Table 3. Soil chemical properties of the two soils used for the conditioned soil experiment. Supplementary Table 4. Selected different threshold (thresholda/b: represent selected the metabolites with the relative abundance greater/less than threshold for model 1/model2 construction) for model construction. Supplementary Table 5. Grouping of metabolites according to their chemical properties. Supplementary Table 6. Pairwise Adonis for multiple pairwise comparisons of rhizosphere metabolites. Supplementary Table 7. Total of 46 metabolites were significant difference and also in the best biomarkers identified by the random forest classifier between the two groups.
DOI: 10.25919/6y4j-nj62
title: Parkes observations for project P1170 semester 2022OCTS_03

description: We request 15.5 hours of observations with the Parkes UWL receiver to search for giant pulses (GPs) in all seven pulsars in the Southern sky which are known to exhibit this phenomenon. The UWL receiver is particularly well-suited to such a study, since some GPs from known emitters have been found to be very narrow-band and so the observed emission rate is likely to be highly frequency-dependent. Additionally, the wide bandwidth allows one to detect spectral structures such as the 'banding' effect recently observed in GPs from some pulsars, similar to that observed in the spectra of fast radio bursts. These observations should provide a wealth of information about the underlying GP emission mechanism, and a stringent test of current theories.
DOI: 10.6084/m9.figshare.21383041
title: Additional file 2 of Moringa as a household water purification method – community perception and pilot study in Guinea-Bissau

description: Additional file 2:
DOI: 10.6084/m9.figshare.21383041.v1
title: Additional file 2 of Moringa as a household water purification method – community perception and pilot study in Guinea-Bissau

description: Additional file 2:
DOI: 10.6084/m9.figshare.21383121
title: Relationship of advanced glycation end-products in hypertension in diabetic patients: a systematic review

description: Abstract Diabetes mellitus and arterial hypertension are among the five risk factors that increase mortality in the world. Both are chronic, non-communicable diseases (NCDs), that have a pathophysiological association. Advanced glycation end products (AGEs), produced by the lack of glycemic control in diabetic patients, interact with their AGE receptors (AGER) resulting in increased arterial stiffness, inflammation and endothelial changes - which increases the risk of developing hypertension and other complications. We ran a systematic review in Pubmed, SciELO, Cochrane Library and Web of Science databases using keywords and Boolean operators to optimize the search, with the objective of assessing the mechanism of non-enzymatic glycation of proteins present in patients with diabetes and its correlation with the onset of hypertension, exposing all the endothelial and cellular damage caused by AGEs. We found 719 papers, of which 99 were read in full, and 26 met the eligibility criteria and were included in the present review. AGEs should be considered one of the main cardiometabolic risk factors. Reducing the AGE-AGER interaction will result in cardiovascular protection and increased life expectancy.
DOI: 10.6084/m9.figshare.21383121.v1
title: Relationship of advanced glycation end-products in hypertension in diabetic patients: a systematic review

description: Abstract Diabetes mellitus and arterial hypertension are among the five risk factors that increase mortality in the world. Both are chronic, non-communicable diseases (NCDs), that have a pathophysiological association. Advanced glycation end products (AGEs), produced by the lack of glycemic control in diabetic patients, interact with their AGE receptors (AGER) resulting in increased arterial stiffness, inflammation and endothelial changes - which increases the risk of developing hypertension and other complications. We ran a systematic review in Pubmed, SciELO, Cochrane Library and Web of Science databases using keywords and Boolean operators to optimize the search, with the objective of assessing the mechanism of non-enzymatic glycation of proteins present in patients with diabetes and its correlation with the onset of hypertension, exposing all the endothelial and cellular damage caused by AGEs. We found 719 papers, of which 99 were read in full, and 26 met the eligibility criteria and were included in the present review. AGEs should be considered one of the main cardiometabolic risk factors. Reducing the AGE-AGER interaction will result in cardiovascular protection and increased life expectancy.
DOI: 10.6084/m9.figshare.21383122
title: Structure, Biomass and Diversity of a Late-Successional Subtropical Atlantic Forest in Brazil

description: Abstract The highly biodiverse Atlantic Forest has been heavily exploited and its remnant areas, which are mostly composed of secondary forests, cover less than 20% of its original extension. This study analyzed the structure, aboveground biomass (AGB) and species diversity of a secondary evergreen rainforest in the state of Santa Catarina, southern Brazil. Individuals with diameter at breast height ≥ 5 cm on 22 sample plots were measured, totalizing 3.49 hectares of sampled area. A mean AGB of 201.6 Mg ha-1 (standard deviation = 35.5) was found; Hyeronima alchorneoides and Miconia cinnamomifolia represented 29.1% and 7.6% of the community AGB ha-1, respectively. A total of 153 species distributed in 107 genera and 55 families was observed; it was estimated that 121 species (95% confidence interval: [117, 125]) occurred in one hectare. These results highlight the importance of secondary forests for biodiversity restoration/conservation and carbon sequestration.
DOI: 10.6084/m9.figshare.21383122.v1
title: Structure, Biomass and Diversity of a Late-Successional Subtropical Atlantic Forest in Brazil

description: Abstract The highly biodiverse Atlantic Forest has been heavily exploited and its remnant areas, which are mostly composed of secondary forests, cover less than 20% of its original extension. This study analyzed the structure, aboveground biomass (AGB) and species diversity of a secondary evergreen rainforest in the state of Santa Catarina, southern Brazil. Individuals with diameter at breast height ≥ 5 cm on 22 sample plots were measured, totalizing 3.49 hectares of sampled area. A mean AGB of 201.6 Mg ha-1 (standard deviation = 35.5) was found; Hyeronima alchorneoides and Miconia cinnamomifolia represented 29.1% and 7.6% of the community AGB ha-1, respectively. A total of 153 species distributed in 107 genera and 55 families was observed; it was estimated that 121 species (95% confidence interval: [117, 125]) occurred in one hectare. These results highlight the importance of secondary forests for biodiversity restoration/conservation and carbon sequestration.
DOI: 10.6084/m9.figshare.21383124
title: A new species of Blechnum L. (Blechnaceae, Polypodiopsida) from central-western Brazil, with an updated key to the species in the country

description: ABSTRACT We describe a new species of Blechnum from Mato Grosso, Brazil: Blechnum rivulorum sp. nov. This new species was discovered as a result of visits to the herbaria BM, K, P, PR, and S, as part of the Reflora Project, by the first author. We also indicate its position in a new Blechnum phylogeny. Additionally, we confirm the occurrence of Blechnum meridense Klotzsch in Brazil and provide an updated key to all species of Blechnum in the country.
DOI: 10.6084/m9.figshare.21383124.v1
title: A new species of Blechnum L. (Blechnaceae, Polypodiopsida) from central-western Brazil, with an updated key to the species in the country

description: ABSTRACT We describe a new species of Blechnum from Mato Grosso, Brazil: Blechnum rivulorum sp. nov. This new species was discovered as a result of visits to the herbaria BM, K, P, PR, and S, as part of the Reflora Project, by the first author. We also indicate its position in a new Blechnum phylogeny. Additionally, we confirm the occurrence of Blechnum meridense Klotzsch in Brazil and provide an updated key to all species of Blechnum in the country.
DOI: 10.6084/m9.figshare.21353282
title: Evolution of the structure and results of Primary Health Care in Brazil between 2008 and 2019

description: Abstract This paper describes the structure and results of Primary Health Care (PHC) in Brazil between 2008 and 2019. The medians of the following variables were calculated: PHC spending per inhabitant covered, PHC coverage, and rates of mortality and hospitalizations due to primary care sensitive conditions (PCSC), in 5,565 Brazilian municipalities stratified according to population size and quintile of the Brazilian Deprivation Index (IBP), and the median trend in the period was analyzed. There was a 12% increase in median PHC spending. PHC coverage expanded, with 3,168 municipalities presenting 100% coverage in 2019, compared to 2,632 in 2008. The median rates of PCSC mortality and hospitalizations increased 0.2% and decreased 44.9%, respectively. PHC spending was lower in municipalities with greater socioeconomic deprivation. The bigger the population and the better the socioeconomic conditions were in the municipalities, the lower the PHC coverage. The greater the socioeconomic deprivation was in the municipalities, the higher the median PCSC mortality rates. This study showed that the evolution of PHC was heterogeneous and is associated both with the population size and with the socioeconomic conditions of the municipalities.
DOI: 10.6084/m9.figshare.21353282.v1
title: Evolution of the structure and results of Primary Health Care in Brazil between 2008 and 2019

description: Abstract This paper describes the structure and results of Primary Health Care (PHC) in Brazil between 2008 and 2019. The medians of the following variables were calculated: PHC spending per inhabitant covered, PHC coverage, and rates of mortality and hospitalizations due to primary care sensitive conditions (PCSC), in 5,565 Brazilian municipalities stratified according to population size and quintile of the Brazilian Deprivation Index (IBP), and the median trend in the period was analyzed. There was a 12% increase in median PHC spending. PHC coverage expanded, with 3,168 municipalities presenting 100% coverage in 2019, compared to 2,632 in 2008. The median rates of PCSC mortality and hospitalizations increased 0.2% and decreased 44.9%, respectively. PHC spending was lower in municipalities with greater socioeconomic deprivation. The bigger the population and the better the socioeconomic conditions were in the municipalities, the lower the PHC coverage. The greater the socioeconomic deprivation was in the municipalities, the higher the median PCSC mortality rates. This study showed that the evolution of PHC was heterogeneous and is associated both with the population size and with the socioeconomic conditions of the municipalities.