cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.31080892.v1
title: Supplementary Material for: The Childhood Shield: How FLOW-MR Unravels the Causal Effects of Time-Varying BMI on Migraine

description: Objectives: To investigate the causal effects of body mass index (BMI) at different life stages (childhood and adulthood) on migraine and its subtypes.
Background: While previous studies suggest BMI is a risk factor for migraine, it is unclear whether BMI influences migraine differently throughout the life course. The causal effect of childhood BMI may have obscured the association between adult BMI and migraine, making it difficult to determine the independent role of adult adiposity.
Methods: We conducted a life-course Mendelian randomization (MR) study. Two-sample and conventional multivariable MR analyses were performed initially. Subsequently, FLOW-MR—a newly-developed three-sample multivariable MR method—was applied to estimate the direct, indirect, and total effects of BMI at childhood or adulthood on migraine. All estimates were scaled per 1-SD increase in BMI (SDs: 1.35 kg/m² at age 1; 1.78 kg/m² at age 8; 4.76 kg/m² in adulthood).
Results: The causal effect of BMI on migraine is strictly dependent on the timing of exposure. First, we found no evidence that adult BMI influences the risk of either migraine subtype. Second, higher BMI at age 8 exerted a direct protective effect against migraine with aura (OR = 0.522). Third, BMI at age 1 exhibited a dual role: its direct risk-increasing effect (OR = 1.983) was offset by an indirect protective effect mediated through 8-year-old BMI (OR = 0.511), resulting in a null total effect on migraine with aura. Migraine without aura was unaffected by BMI at any life stage.
Conclusion: The causal effect of BMI on migraine is dependent on developmental timing, challenging the conventional view of BMI as a uniform risk factor. We emphasize that the observed protective role of childhood BMI is a model-estimated association from genetic data, which does not constitute a recommendation to increase body weight in children.
DOI: 10.6084/m9.figshare.31080895
title: Supplementary Material for: Different diagnoses, common ancestry: 22q11.2 deletion syndrome and Wiskott-Aldrich syndrome in the same family

description: Introduction: Newborn screening program enable pre-symptomatic detection patients with severe forms of T and B cell immunodeficiency. Despite the high prevalence of 22q11.2 deletion syndrome, only 1 in 10 patients develop lymphopenia that can be detected by newborn screening program. This report presents a unique familial case of 22q11.2 deletion syndrome and Wiskott-Aldrich syndrome, highlighting the importance genetic counseling and a detailed analysis of the family history. Case Presentation: The article presents a case of the two rare genetic diseases in patients from the same family: 22q11.2 deletion syndrome in one and Wiskott-Aldrich syndrome in the other. Both diseases belong to the group of combined immunodeficiencies with syndromic features and are potentially life-threatening conditions requiring follow-up by a wide range of specialists: immunologists, geneticists, cardiologists, endocrinologists, and medical psychologists. Conclusion: Our work aimed to describe the clinical manifestations, genetic characteristics, and diagnosis of these disorders. It is worth emphasizing that the timely diagnosis of not only 22q11.2 deletion syndrome but also other primary immunodeficiencies in the Russian Federation became possible due to the introduction of extended neonatal screening into widespread practice. For such patients, comprehensive early interventive treatment and follow-up by a wide range of specialists is important to improve prognosis and quality of life.
DOI: 10.6084/m9.figshare.31080895.v1
title: Supplementary Material for: Different diagnoses, common ancestry: 22q11.2 deletion syndrome and Wiskott-Aldrich syndrome in the same family

description: Introduction: Newborn screening program enable pre-symptomatic detection patients with severe forms of T and B cell immunodeficiency. Despite the high prevalence of 22q11.2 deletion syndrome, only 1 in 10 patients develop lymphopenia that can be detected by newborn screening program. This report presents a unique familial case of 22q11.2 deletion syndrome and Wiskott-Aldrich syndrome, highlighting the importance genetic counseling and a detailed analysis of the family history. Case Presentation: The article presents a case of the two rare genetic diseases in patients from the same family: 22q11.2 deletion syndrome in one and Wiskott-Aldrich syndrome in the other. Both diseases belong to the group of combined immunodeficiencies with syndromic features and are potentially life-threatening conditions requiring follow-up by a wide range of specialists: immunologists, geneticists, cardiologists, endocrinologists, and medical psychologists. Conclusion: Our work aimed to describe the clinical manifestations, genetic characteristics, and diagnosis of these disorders. It is worth emphasizing that the timely diagnosis of not only 22q11.2 deletion syndrome but also other primary immunodeficiencies in the Russian Federation became possible due to the introduction of extended neonatal screening into widespread practice. For such patients, comprehensive early interventive treatment and follow-up by a wide range of specialists is important to improve prognosis and quality of life.
DOI: 10.6084/m9.figshare.31080898
title: Supplementary Material for: Chronic Diabetic Foot Ulcer treated with Homoeopathy as adjuvant in an Integrative Management Model: An Evidence-based case report

description: Abstract:
Introduction: Diabetic foot ulcers (DFUs), among the most severe complications associated with diabetes, impose a substantial economic and public health burden due to their significant prevalence (15–25%). In India, the escalating incidence of DFUs has markedly increased the frequency of lower-limb amputations. This case seeks to examine the potential wound healing efficacy of homeopathic medicines as part of an integrative approach to DFU management, demonstrated through evidence-based case reports.
Case presentation: Patient presenting with DFUs classified as Wagner grade 2 and with a 12-year history of diabetes were managed using individualized homeopathic treatment. Alongside homeopathic intervention, patients continued their prescribed oral hypoglycemic agents for glycemic control and adhered to routine wound-dressing protocols. DFU was monitored until complete healing using the Leg Ulcer Measurement Tool (LUMT). Neuropathic involvement was evaluated via the 10g monofilament tactile test, while the Modified Naranjo Criteria for Homeopathy Inventory (MONARCH) tool was employed to determine the probability of a causal relationship between the observed clinical improvement and the homeopathic treatment. Within 12 weeks, the DFU demonstrated notable healing, reflected in a significant reduction in LUMT scores. The MONARCH tool assessment yielded a score of +8, strongly suggesting a causal link between the observed therapeutic outcomes and the homeopathic intervention. The homeopathic remedies administered were found to contribute effectively to the patient’s recovery.
Conclusion: Adjuvant Homeopathic treatment appeared to play a supportive role in expediting the healing process of DFUs within a clinically acceptable timeframe.
DOI: 10.6084/m9.figshare.31080898.v1
title: Supplementary Material for: Chronic Diabetic Foot Ulcer treated with Homoeopathy as adjuvant in an Integrative Management Model: An Evidence-based case report

description: Abstract:
Introduction: Diabetic foot ulcers (DFUs), among the most severe complications associated with diabetes, impose a substantial economic and public health burden due to their significant prevalence (15–25%). In India, the escalating incidence of DFUs has markedly increased the frequency of lower-limb amputations. This case seeks to examine the potential wound healing efficacy of homeopathic medicines as part of an integrative approach to DFU management, demonstrated through evidence-based case reports.
Case presentation: Patient presenting with DFUs classified as Wagner grade 2 and with a 12-year history of diabetes were managed using individualized homeopathic treatment. Alongside homeopathic intervention, patients continued their prescribed oral hypoglycemic agents for glycemic control and adhered to routine wound-dressing protocols. DFU was monitored until complete healing using the Leg Ulcer Measurement Tool (LUMT). Neuropathic involvement was evaluated via the 10g monofilament tactile test, while the Modified Naranjo Criteria for Homeopathy Inventory (MONARCH) tool was employed to determine the probability of a causal relationship between the observed clinical improvement and the homeopathic treatment. Within 12 weeks, the DFU demonstrated notable healing, reflected in a significant reduction in LUMT scores. The MONARCH tool assessment yielded a score of +8, strongly suggesting a causal link between the observed therapeutic outcomes and the homeopathic intervention. The homeopathic remedies administered were found to contribute effectively to the patient’s recovery.
Conclusion: Adjuvant Homeopathic treatment appeared to play a supportive role in expediting the healing process of DFUs within a clinically acceptable timeframe.
DOI: 10.6084/m9.figshare.31080901
title: Supplementary Material for: Bilateral Optic Disc Edema Secondary to Severe Vitamin A Deficiency: A Rare Cause of Acute Vision Loss

description: Introduction: We report a rare case of bilateral optic disc edema in a patient found to have severe vitamin A deficiency. While vitamin A deficiency typically presents with optic disc atrophy, this case emphasizes the importance of considering vitamin A deficiency in patients with atypical optic disc edema.

Case Presentation: A 39-year-old female with a history of disordered eating habits and extensive psychiatric history presented to the emergency department with acute onset cloudiness and blurring of her vision bilaterally. Physical exam was notable for bilateral optic disc edema in the absence of increased intracranial pressure, as demonstrated by an unremarkable MRI and lumbar puncture opening pressure of 18 cmH2O. Extensive testing on serum and cerebrospinal fluid was notable only for a serum vitamin A level of less than 5 mcg/dL (normal: 38-98 mcg/dL). The patient underwent inpatient hospitalization and was given 100,000 units of intramuscular vitamin A for 3 days with 50,000 units per day for the following two weeks. A follow-up visit one month later revealed resolution of her optic disc edema in the right eye and only mild optic disc edema in the left eye.

Conclusion: We describe a case of bilateral optic disc edema in a patient with severe vitamin A deficiency, underscoring the potential for nutritional abnormalities to present in this fashion. We also emphasize a multidisciplinary approach to unveil the underlying causes of atypical presentations of optic disc edema and create an appropriate treatment plan for patients with nutritional deficiencies.
DOI: 10.6084/m9.figshare.31080901.v1
title: Supplementary Material for: Bilateral Optic Disc Edema Secondary to Severe Vitamin A Deficiency: A Rare Cause of Acute Vision Loss

description: Introduction: We report a rare case of bilateral optic disc edema in a patient found to have severe vitamin A deficiency. While vitamin A deficiency typically presents with optic disc atrophy, this case emphasizes the importance of considering vitamin A deficiency in patients with atypical optic disc edema.

Case Presentation: A 39-year-old female with a history of disordered eating habits and extensive psychiatric history presented to the emergency department with acute onset cloudiness and blurring of her vision bilaterally. Physical exam was notable for bilateral optic disc edema in the absence of increased intracranial pressure, as demonstrated by an unremarkable MRI and lumbar puncture opening pressure of 18 cmH2O. Extensive testing on serum and cerebrospinal fluid was notable only for a serum vitamin A level of less than 5 mcg/dL (normal: 38-98 mcg/dL). The patient underwent inpatient hospitalization and was given 100,000 units of intramuscular vitamin A for 3 days with 50,000 units per day for the following two weeks. A follow-up visit one month later revealed resolution of her optic disc edema in the right eye and only mild optic disc edema in the left eye.

Conclusion: We describe a case of bilateral optic disc edema in a patient with severe vitamin A deficiency, underscoring the potential for nutritional abnormalities to present in this fashion. We also emphasize a multidisciplinary approach to unveil the underlying causes of atypical presentations of optic disc edema and create an appropriate treatment plan for patients with nutritional deficiencies.
DOI: 10.5281/zenodo.18277686
title: Galactia martioides Burkart. In: Marchesi E., Mailhos A. & Bonifacino J.M. (Eds.). Flora Uruguaya: Flora Vascular del Uruguay. ISSN 3121-2050, V. 1.0.

description: Citable snapshot. Includes PDF and CSV of collections. Date: January 13th, 2026 at 16:47
DOI: 10.5281/zenodo.18277697
title: Galactia neesii DC. In: Marchesi E., Mailhos A. & Bonifacino J.M. (Eds.). Flora Uruguaya: Flora Vascular del Uruguay. ISSN 3121-2050, V. 1.0.

description: Citable snapshot. Includes PDF and CSV of collections. Date: January 13th, 2026 at 16:47
DOI: 10.5281/zenodo.18277687
title: Galactia martioides Burkart. In: Marchesi E., Mailhos A. & Bonifacino J.M. (Eds.). Flora Uruguaya: Flora Vascular del Uruguay. ISSN 3121-2050, V. 1.0.

description: Citable snapshot. Includes PDF and CSV of collections. Date: January 13th, 2026 at 16:47
DOI: 10.5281/zenodo.18277696
title: Galactia neesii DC. In: Marchesi E., Mailhos A. & Bonifacino J.M. (Eds.). Flora Uruguaya: Flora Vascular del Uruguay. ISSN 3121-2050, V. 1.0.

description: Citable snapshot. Includes PDF and CSV of collections. Date: January 13th, 2026 at 16:47
DOI: 10.5281/zenodo.18277702
title: Galactia neesii var. australis Malme. In: Marchesi E., Mailhos A. & Bonifacino J.M. (Eds.). Flora Uruguaya: Flora Vascular del Uruguay. ISSN 3121-2050, V. 1.0.

description: Citable snapshot. Includes PDF and CSV of collections. Date: January 13th, 2026 at 16:47
DOI: 10.5281/zenodo.18277701
title: Galactia neesii var. australis Malme. In: Marchesi E., Mailhos A. & Bonifacino J.M. (Eds.). Flora Uruguaya: Flora Vascular del Uruguay. ISSN 3121-2050, V. 1.0.

description: Citable snapshot. Includes PDF and CSV of collections. Date: January 13th, 2026 at 16:47
DOI: 10.15468/dl.7tm4az
title: Occurrence Download

description: A dataset containing 304476 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Turdus torquatus",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "Geometry POLYGON((-180 -90, 180 -90, 180 90, -180 90, -180 -90))"
 ]
}

 The dataset includes 304476 records from 778 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0016119-260108223611665/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.vqeytz
title: Occurrence Download

description: A dataset containing 20663 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Calathus fuscipes (Goeze, 1777)",
 "HasCoordinate is true"
 ]
}

 The dataset includes 20663 records from 352 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0008687-250515123054153/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.2x84m9
title: Occurrence Download

description: A dataset containing 229 species occurrences available in GBIF matching the query:
{
 "and" : [
 "StateProvince is Texas",
 "TaxonKey is Setophaga chrysoparia (P.L.Sclater & Salvin, 1860)",
 "Year 2024-2024"
 ]
}

 The dataset includes 229 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0003022-250426092105405/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.nhyxtk
title: Occurrence Download

description: A dataset containing 150983 species occurrences available in GBIF matching the query:
{
 "and" : [
 "OccurrenceStatus is Present",
 "Year is greater than or equal to 1980",
 "TaxonKey is one of (Psittacula eupatria (Linnaeus, 1766), Psittacus eupatria Linnaeus, 1766, Palaeornis eupatria (Linnaeus, 1766))",
 {
 "or" : [
 "CoordinateUncertaintyInMeters is less than 10000",
 "CoordinateUncertaintyInMeters is null"
 ]
 },
 "BasisOfRecord is one of (Human Observation, Observation, Specimen)",
 "HasCoordinate is true",
 {
 "not" : {
 "Country" : [
 "is one of (American Samoa, Guam, Northern Mariana Islands, Puerto Rico, United States Minor Outlying Islands, United States of America, Virgin Islands (U.S.))"
 ]
 }
 }
 ]
}

 The dataset includes 150983 records from 43 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0003011-250426092105405/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.kbx429
title: Occurrence Download

description: A dataset containing 2490 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Plecturocebus Byrne, Rylands, Carneiro, Lynch Alfaro et al., 2016"
 ]
}

 The dataset includes 2490 records from 77 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0003023-250426092105405/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.25446/oxford.28883651
title: <b>3D models of the early human umbilical vasculature</b>.tif

description: <b>3D models of the early human umbilical vasculature. </b>(A)<b> </b>A Carnegie stage (CS)9 embryo with an attached connecting stalk (precursor to umbilical cord and feto-placental vasculature, yellow) with arterial vessels (red), which is earlier than previously thought (O'Rahilly and Müller, 1987). The human allantois is shown in cyan. The human allantois is a separate structure to the mouse allantois. The ‘allantois’ or ‘allantoic diverticulum’ in humans is a separate structure from the umbilical cord vessels and ‘feto–placental’ vessels that derive from the connecting stalk. The human allantois forms a singular extension from the hindgut, which exists temporarily between the two umbilical arteries. It regresses from the umbilical cord to connect the hindgut to the cloaca and eventually becomes the ‘urachus’ or ‘umbilical ligament’ (O'Rahilly and Müller 1987, Kruepunga et al. 2018). The connecting stalk is equivalent to the mouse allantois. (B) A CS11 embryo without a connecting stalk/early umbilical cord but containing arterial vessels near the umbilical-embryonic junction (yellow line). (C) A CS15 embryo, with arterial (red) and venous (green) vasculature and allantois (cyan) in the umbilical cord. Human embryo image stacks (CS9/CS11) taken from DREM Carnegie collection (The Virtual Human Embryo, 2019). High Resolution Episcopic Microscopy (HREM) CS15 stack came from Wellcome Trust DMDD project. 3D models were created using Amira software (Life & Biomedical Sciences version 2019.4, Thermo Fisher Scientific).
DOI: 10.25446/oxford.28883651.v1
title: <b>3D models of the early human umbilical vasculature</b>.tif

description: <b>3D models of the early human umbilical vasculature. </b>(A)<b> </b>A Carnegie stage (CS)9 embryo with an attached connecting stalk (precursor to umbilical cord and feto-placental vasculature, yellow) with arterial vessels (red), which is earlier than previously thought (O'Rahilly and Müller, 1987). The human allantois is shown in cyan. The human allantois is a separate structure to the mouse allantois. The ‘allantois’ or ‘allantoic diverticulum’ in humans is a separate structure from the umbilical cord vessels and ‘feto–placental’ vessels that derive from the connecting stalk. The human allantois forms a singular extension from the hindgut, which exists temporarily between the two umbilical arteries. It regresses from the umbilical cord to connect the hindgut to the cloaca and eventually becomes the ‘urachus’ or ‘umbilical ligament’ (O'Rahilly and Müller 1987, Kruepunga et al. 2018). The connecting stalk is equivalent to the mouse allantois. (B) A CS11 embryo without a connecting stalk/early umbilical cord but containing arterial vessels near the umbilical-embryonic junction (yellow line). (C) A CS15 embryo, with arterial (red) and venous (green) vasculature and allantois (cyan) in the umbilical cord. Human embryo image stacks (CS9/CS11) taken from DREM Carnegie collection (The Virtual Human Embryo, 2019). High Resolution Episcopic Microscopy (HREM) CS15 stack came from Wellcome Trust DMDD project. 3D models were created using Amira software (Life & Biomedical Sciences version 2019.4, Thermo Fisher Scientific).
DOI: 10.15468/dl.ueah76
title: Occurrence Download

description: A dataset containing 1365444 species occurrences available in GBIF matching the query:
{
 "and" : [
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 "TaxonKey is Achillea millefolium L."
 ]
}

 The dataset includes 1365444 records from 4345 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0008808-250525065834625/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.4w8bxd
title: Occurrence Download

description: A dataset containing 223110219 records in GBIF matching the query:
SELECT catalognumber, scientificname, publishingorgkey, institutioncode, datasetkey, gbifid, decimallatitude, decimallongitude, 
 recordedby, identifiedby, eventdate, kingdomkey, phylumkey, classkey, orderkey, familykey, genuskey, subgenuskey, specieskey,
 mediatype, v_associatedmedia
 FROM occurrence WHERE
 phylumkey = 54 
 AND taxonomicstatus = 'ACCEPTED' //newly added 12Feb2025
 AND hascoordinate = 1
 AND hasgeospatialissues = 0
 AND specieskey IS NOT NULL
 AND occurrencestatus = 'PRESENT'
 -- AND (
 -- basisofrecord = 'HUMAN_OBSERVATION'
 -- OR basisofrecord = 'MACHINE_OBSERVATION'
 -- OR basisofrecord = 'OCCURRENCE'
 -- OR basisofrecord = 'LIVING_SPECIMEN'
 -- OR basisofrecord = 'MATERIAL_SAMPLE'
 -- )
 AND NOT ARRAY_CONTAINS(issue, 'ZERO_COORDINATE')
 AND NOT ARRAY_CONTAINS(issue, 'COORDINATE_OUT_OF_RANGE') AND datasetkey NOT IN ('040c5662-da76-4782-a48e-cdea1892d14c') 

 The dataset's 223110219 records were derived from 21382 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0011309-250415084134356/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.