cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.5281/zenodo.7105094
title: Supplementary 1 The ingroup of Apis cerana and outgroup species used for haplotype and phylogenetic analysis based on COX1, COX2, and IGS

description: The ingroup of <em>Apis cerana</em> and outgroup species used for haplotype and phylogenetic analysis based on <em>COX1, COX2,</em> and IGS
DOI: 10.5281/zenodo.7112258
title: Supplementary 1 The ingroup of Apis cerana and outgroup species used for haplotype and phylogenetic analysis based on COX1, COX2, and IGS

description: The ingroup of <em>Apis cerana</em> and outgroup species used for haplotype and phylogenetic analysis based on <em>COX1, COX2,</em> and IGS
DOI: 10.6084/m9.figshare.22141184.v1
title: Factor Modelling for Clustering High-dimensional Time Series

description: We propose a new unsupervised learning method for clustering a large number of time series based on a latent factor structure. Each cluster is characterized by its own cluster-specific factors in addition to some common factors which impact on all the time series concerned. Our setting also offers the flexibility that some time series may not belong to any clusters. The consistency with explicit convergence rates is established for the estimation of the common factors, the cluster-specific factors, and the latent clusters. Numerical illustration with both simulated data as well as a real data example is also reported. As a spin-off, the proposed new approach also advances significantly the statistical inference for the factor model of Lam and Yao (2012).
DOI: 10.5281/zenodo.10639139
title: Exploring the Interplay between Ankle Muscle Strength, Postural Control, and Pain Intensity in Chronic Ankle Instability: A Comprehensive Analysis.
DOI: 10.5281/zenodo.10639140
title: Exploring the Interplay between Ankle Muscle Strength, Postural Control, and Pain Intensity in Chronic Ankle Instability: A Comprehensive Analysis.
DOI: 10.6084/m9.figshare.12703956.v1
title: Additional file 2 of Exogenous 2-(3,4-Dichlorophenoxy) triethylamine alleviates salinity stress in maize by enhancing photosynthetic capacity, improving water status and maintaining K+/Na+ homeostasis

description: Additional file 2. Research data.
DOI: 10.6084/m9.figshare.12703701
title: Additional file 12 of Long non-coding RNA H19 promotes colorectal cancer metastasis via binding to hnRNPA2B1

description: Additional file 12: Table S4. Identifed the proteins binding to H19 by LC-MS
DOI: 10.6084/m9.figshare.22141184.v3
title: Factor Modeling for Clustering High-Dimensional Time Series

description: We propose a new unsupervised learning method for clustering a large number of time series based on a latent factor structure. Each cluster is characterized by its own cluster-specific factors in addition to some common factors which impact on all the time series concerned. Our setting also offers the flexibility that some time series may not belong to any clusters. The consistency with explicit convergence rates is established for the estimation of the common factors, the cluster-specific factors, and the latent clusters. Numerical illustration with both simulated data as well as a real data example is also reported. As a spin-off, the proposed new approach also advances significantly the statistical inference for the factor model of Lam and Yao. Supplementary materials for this article are available online.
DOI: 10.6084/m9.figshare.22141184.v2
title: Factor Modeling for Clustering High-Dimensional Time Series

description: We propose a new unsupervised learning method for clustering a large number of time series based on a latent factor structure. Each cluster is characterized by its own cluster-specific factors in addition to some common factors which impact on all the time series concerned. Our setting also offers the flexibility that some time series may not belong to any clusters. The consistency with explicit convergence rates is established for the estimation of the common factors, the cluster-specific factors, and the latent clusters. Numerical illustration with both simulated data as well as a real data example is also reported. As a spin-off, the proposed new approach also advances significantly the statistical inference for the factor model of Lam and Yao. Supplementary materials for this article are available online.
DOI: 10.6084/m9.figshare.12179715.v1
title: Autophagy triggers CTSD (cathepsin D) maturation and localization inside cells to promote apoptosis

description: CTSD/CathD/CATD (cathepsin D) is a lysosomal aspartic protease. A distinguishing characteristic of CTSD is its dual functions of promoting cell proliferation via secreting a pro-enzyme outside the cells as a ligand, and promoting apoptosis via the mature form of this enzyme inside cells; however, the regulation of its secretion, expression, and maturation is undetermined. Using the lepidopteran insect <i>Helicoverpa armigera</i>, a serious agricultural pest, as a model, we revealed the dual functions and regulatory mechanisms of CTSD secretion, expression, and maturation. Glycosylation of asparagine 233 (N233) determined pro-CTSD secretion. The steroid hormone 20-hydroxyecdysone (20E) promoted CTSD expression. Macroautophagy/autophagy triggered CTSD maturation and localization inside midgut cells to activate CASP3 (caspase 3) and promote apoptosis. Pro-CTSD was expressed in the pupal epidermis and was secreted into the hemolymph to promote adult fat body endoreplication/endoreduplication, cell proliferation, and association. Our study revealed that the differential expression and autophagy-mediated maturation of CTSD in tissues determine its roles in apoptosis and cell proliferation, thereby determining the cell fates of tissues during lepidopteran metamorphosis. <b>Abbreviations:</b> 20E: 20-hydroxyecdysone; 3-MA: 3-methyladenine; ACTB/β-actin: actin beta; AKT: protein kinase B; ATG1: autophagy-related 1; ATG4: autophagy-related 4; ATG5: autophagy-related 5; ATG7: autophagy-related 7; ATG14: autophagy-related 14; BSA: bovine serum albumin; CASP3: caspase 3; CQ: choroquine; CTSD: cathepsin D; DAPI: 4′,6-diamidino-2-phenylindole; DMSO: dimethyl sulfoxide; DPBS: dulbecco’s phosphate-buffered saline; DsRNA: double-stranded RNA; EcR: ecdysone receptor; EcRE: ecdysone response element; EdU: 5-ethynyl-2´-deoxyuridine; G-m-CTSD: glycosylated-mautre-CTSD; G-pro-CTSD: glycosylated-pro-CTSD; HaEpi: <i>Helicoverpa armigera</i> epidermal cell line; HE staining: hematoxylin and eosin staining; IgG: immunoglobin G; IM: imaginal midgut; JH: juvenile hormone; Kr-h1: krueppel homologous protein 1; LM: larval midgut; M6P: mannose-6-phosphate; PBS: phosphate-buffered saline; PCD: programmed cell death; PNGase: peptide-N-glycosidase F; RFP: red fluorescent protein; RNAi: RNA interference; SDS-PAGE: sodium dodecyl sulfate-polyacrylamide gel electrophoresis; SYX17: syntaxin 17; USP1: ultraspiracle isoform 1.
DOI: 10.6084/m9.figshare.14795335
title: Additional file 2 of Rapid identification of mutations caused by fast neutron bombardment in Medicago truncatula

description: Additional file 2: Table S1. The potential deletions in wn mutant. The details of potential deletions in wn mutant populations were listed, which include the location, sequence, length, genotype in different samples and the mutant type of deletions.
DOI: 10.6084/m9.figshare.14795335.v1
title: Additional file 2 of Rapid identification of mutations caused by fast neutron bombardment in Medicago truncatula

description: Additional file 2: Table S1. The potential deletions in wn mutant. The details of potential deletions in wn mutant populations were listed, which include the location, sequence, length, genotype in different samples and the mutant type of deletions.
DOI: 10.6084/m9.figshare.13154069.v1
title: Metadata record for the manuscript: Glembatumumab vedotin for patients with metastatic, gpNMB over-expressing, triplenegative breast cancer (“METRIC”): A Randomized Multicenter Study

description: <b>Summary</b>

This
metadata record provides details of the data supporting the claims of the
related manuscript: “Glembatumumab vedotin for patients with metastatic, gpNMB
over-expressing, triplenegative breast cancer (“METRIC”): A Randomized
Multicenter Study”.

The
related study evaluated whether glembatumumab vedotin (a gpNMB-specific
monoclonal antibody conjugated to the potent cytotoxin monomethyl auristatin E)
would improve progression-free survival compared to capecitabine in
gpNMB-overexpressing triple-negative breast cancer (TNBC).

 

<b>Data
access</b>

The data are are available from the company which funded the study--Celldex Therapeutics, Inc (https://www.celldex.com/)--on reasonable request for a period of 3 years following publication. After this period Celldex does not commit to making the data available as the compound has been discontinued from development.<br>

The
data, along with details of the figures and tables in the manuscript that they
underlie, are as follows:

Figure 2: CDX011-04_ADEF.sas;
CDX011-04_ADEFI.sas; CDX011-04_ADTTE.sas

Figure 3: CDX011-04_ADEF.sas;
CDX011-04_ADEFI.sas

Figure 4: CDX011-04_ADEFI.sas;
CDX011-04_ADTTE.sas

Table 1: CDX011-04_ADSL.sas;
CDX011-04_ADMH.sas

Table 2: CDX011-04_ADEF.sas;
CDX011-04_ADEFI.sas; CDX011-04_ADTTE.sas

Table 3: CDX011-04_RawPK.xls

Table 4: CDX011-04_ADAE.sas

Supplemental
Table 1: CDX011-04_ADCM.sas

Supplemental
Table 2: CDX011-04_ADEF.sas; CDX011-04_ADEFI.sas; CDX011-04_ADTTE.sas

 

For
all data requests please contact Celldex at: info@celldex.com 
<b>Name of Institutional
Review Board or ethics committee that approved the study </b>

The study was conducted
at 120 sites in the United States, Canada, Australia, United Kingdom, France,
Spain, Belgium, Germany, and Italy. The study was conducted at each of the
participating institutions according to the Declaration of Helsinki and Good
Clinical Practice Guidelines, after approval by local institutional/ethics review
boards.

 

<b>Clinical trial registry URL</b>

https://www.clinicaltrials.gov/ct2/show/NCT01997333?term=NCT#01997333&draw=2&rank=1

<br>
DOI: 10.6084/m9.figshare.14795272.v1
title: Additional file 3 of Machine learning-based prediction of survival prognosis in cervical cancer

description: Additional file 3
DOI: 10.6084/m9.figshare.23714074.v1
title: Additional file 1 of Expression of circ-PHC3 enhances ovarian cancer progression via regulation of the miR-497-5p/SOX9 pathway

description: Additional file 1.
DOI: 10.6084/m9.figshare.23714074
title: Additional file 1 of Expression of circ-PHC3 enhances ovarian cancer progression via regulation of the miR-497-5p/SOX9 pathway

description: Additional file 1.
DOI: 10.5281/zenodo.10639197
title: Supplementary 1 The ingroup of Apis cerana and outgroup species used for haplotype and phylogenetic analysis based on the cox1, cox2 genes, and igs

description: The ingroup of Apis cerana and outgroup species used for haplotype and phylogenetic analysis based on the cox1, cox2 genes, and igs
DOI: 10.5281/zenodo.7105093
title: Supplementary 1 The ingroup of Apis cerana and outgroup species used for haplotype and phylogenetic analysis based on the cox1, cox2 genes, and igs

description: The ingroup of Apis cerana and outgroup species used for haplotype and phylogenetic analysis based on the cox1, cox2 genes, and igs
DOI: 10.6084/m9.figshare.14795570
title: Additional file 1 of Transcriptome profiling reveals the spatial-temporal dynamics of gene expression essential for soybean seed development

description: Additional file 1.
DOI: 10.6084/m9.figshare.14795570.v1
title: Additional file 1 of Transcriptome profiling reveals the spatial-temporal dynamics of gene expression essential for soybean seed development

description: Additional file 1.
DOI: 10.24403/jp.1330392
title: Görts-van Rijn, A.R.A. (Editor): Flora of the Guianas. - Königstein : Koeltz Scientific Books, 1985 - 1995 / [rezensiert von] H. Manitz
DOI: 10.25549/usctheses-c89-288171
title: etd-BucholtzBr-8318
DOI: 10.25549/usctheses-ouc11673178
title: Chapter One: Overview of the Study
DOI: 10.24403/jp.1330393
title: Gonzalez Ayala, J. C.: Botánica Medicinal Popular. Etnobotánica Medicinal de El Salvador. - San Salvador : Jardin Botanico La Laguna, 1994 / [rezensiert von] H. Manitz
DOI: 10.6084/m9.figshare.14795150.v1
title: Additional file 4 of Genome-wide DNA methylation analysis in Chinese Chenghua and Yorkshire pigs

description: Additional file 4: Table S4. Summary of hypomethylation genes in CHP vs. YP.
DOI: 10.6084/m9.figshare.14795272
title: Additional file 3 of Machine learning-based prediction of survival prognosis in cervical cancer

description: Additional file 3
DOI: 10.25549/usctheses-ouc11673210
title: Microsoft Word - 02.15.20 Emotive Matter.docx
DOI: 10.25549/usctheses-ouc11673223
title: Microsoft Word - Kamaldeep Kaur Final Manuscript USC 2020 UploadApril2020.docx
DOI: 10.25549/usctheses-c89-289251
title: etd-VillegasCh-8315
DOI: 10.25549/usctheses-ouc11673322
title: 2020-04-27 FINAL Capstone Paper_Transgender Anesthesia (Gallegos).pdf
DOI: 10.24403/jp.1330394
title: Hildebrand, F.: Die Verbreitungsmittel der Pflanzen. - Leipzig : Verlag W. Engelmann, 1873. - Reprint . - Bad Münstereifel : IDH-Verlag, 1995 / [rezensiert von] H. Manitz
DOI: 10.24403/jp.1330395
title: Hoppea : Denkschriften der Regensburgischen Botanischen Gesellschaft, Band 50-57. - Regensburg : Verlag der Gesellschaft, 1991-1996 / [rezensiert von] H. Manitz
DOI: 10.25549/usctheses-c89-288546
title: etd-StevensonA-8313a
DOI: 10.6084/m9.figshare.9034100.v1
title: Intra-host emergence of an enterovirus A71 variant with enhanced PSGL1 usage and neurovirulence

description: Enterovirus A71 (EV-A71) is one of the main causative agents of hand-foot-and-mouth disease and is occasionally associated with severe neurological complications. EV-A71 pathophysiology is poorly understood due to the lack of small animal models that robustly support viral replication in relevant organs/tissues. Here, we show that adult severe combined immune-deficient (SCID) mice can serve as an EV-A71 infection model to study neurotropic determinants and viral tropism. Mice inoculated intraperitoneally with an EV-A71 clinical isolate had an initial infection of the lung compartment, followed by neuroinvasion and infection of (motor)neurons, resulting in slowly progressing paralysis of the limbs. We identified a substitution (V135I) in the capsid protein VP2 as a key requirement for neurotropism. This substitution was also present in a mouse-adapted variant, obtained by passaging the clinical isolate in the brain of one-day-old mice, and induced exclusive neuropathology and rapid paralysis, confirming its role in neurotropism. Finally, we showed that this residue enhances the capacity of EV-A71 to use mouse PSGL1 for viral entry. Our data reveal that EV-A71 initially disseminates to the lung and identify viral and host determinants that define the neurotropic character of EV-A71, pointing to a hitherto understudied role of PSGL1 in EV-A71 tropism and neuropathology.
DOI: 10.6084/m9.figshare.14795269
title: Additional file 2 of Machine learning-based prediction of survival prognosis in cervical cancer

description: Additional file 2
DOI: 10.5281/zenodo.7756570
title: A Pan-European, Quantile Machine learning (QML) based, Total, Fine-Mode and Coarse-Mode Aerosol Optical Depth dataset (QML AOD))

description: Given the limitations of existing Aerosol Optical Depth (AOD) datasets and their inability to provide size fraction information, we developed quantile machine learning (QML) models to produce an 18-year (2003-2020) daily AOD dataset for Europe with a high spatial resolution of 0.1°. This new dataset enables monitoring and analysis of both fine-mode (fAOD) and coarse-mode (cAOD) aerosols, providing a valuable tool to investigate their negative impacts on human health and the environment, including climate, visibility, and biogeochemical cycling. We have uploaded three QML AOD datasets in Geotiff format, covering the region from -27° to 72° latitude and from -25° to 45° longitude. These datasets will be useful for researchers and policymakers to better understand the impacts of aerosols on the environment and human health.
DOI: 10.6084/m9.figshare.7461734
title: D-CCA: A Decomposition-Based Canonical Correlation Analysis for High-Dimensional Datasets

description: A typical approach to the joint analysis of two high-dimensional datasets is to decompose each data matrix into three parts: a low-rank common matrix that captures the shared information across datasets, a low-rank distinctive matrix that characterizes the individual information within a single dataset, and an additive noise matrix. Existing decomposition methods often focus on the orthogonality between the common and distinctive matrices, but inadequately consider the more necessary orthogonal relationship between the two distinctive matrices. The latter guarantees that no more shared information is extractable from the distinctive matrices. We propose decomposition-based canonical correlation analysis (D-CCA), a novel decomposition method that defines the common and distinctive matrices from the ℓ2 space of random variables rather than the conventionally used Euclidean space, with a careful construction of the orthogonal relationship between distinctive matrices. D-CCA represents a natural generalization of the traditional canonical correlation analysis. The proposed estimators of common and distinctive matrices are shown to be consistent and have reasonably better performance than some state-of-the-art methods in both simulated data and the real data analysis of breast cancer data obtained from The Cancer Genome Atlas. Supplementary materials for this article are available online.
DOI: 10.6084/m9.figshare.9034100.v2
title: Intra-host emergence of an enterovirus A71 variant with enhanced PSGL1 usage and neurovirulence

description: Enterovirus A71 (EV-A71) is one of the main causative agents of hand-foot-and-mouth disease and is occasionally associated with severe neurological complications. EV-A71 pathophysiology is poorly understood due to the lack of small animal models that robustly support viral replication in relevant organs/tissues. Here, we show that adult severe combined immune-deficient (SCID) mice can serve as an EV-A71 infection model to study neurotropic determinants and viral tropism. Mice inoculated intraperitoneally with an EV-A71 clinical isolate had an initial infection of the lung compartment, followed by neuroinvasion and infection of (motor)neurons, resulting in slowly progressing paralysis of the limbs. We identified a substitution (V135I) in the capsid protein VP2 as a key requirement for neurotropism. This substitution was also present in a mouse-adapted variant, obtained by passaging the clinical isolate in the brain of one-day-old mice, and induced exclusive neuropathology and rapid paralysis, confirming its role in neurotropism. Finally, we showed that this residue enhances the capacity of EV-A71 to use mouse PSGL1 for viral entry. Our data reveal that EV-A71 initially disseminates to the lung and identify viral and host determinants that define the neurotropic character of EV-A71, pointing to a hitherto understudied role of PSGL1 in EV-A71 tropism and neuropathology.
DOI: 10.6084/m9.figshare.7986224
title: Additional file 1: of Systematic identification and validation of the reference genes from 60 RNA-Seq libraries in the scallop Mizuhopecten yessoensis

description: Table S1. Detailed information on the RNA-Seq datasets (XLSM 9 kb)
DOI: 10.6084/m9.figshare.7986257.v1
title: Additional file 1: of Comparative genomic analysis of Bacillus paralicheniformis MDJK30 with its closely related species reveals an evolutionary relationship between B. paralicheniformis and B. licheniformis

description: Table S1. The features of prophage, genomic islands, secondary metabolite clusters and CRISPR in MDJK30 genome. (XLSX 14 kb)
DOI: 10.6084/m9.figshare.7986287.v1
title: Additional file 5: of Comparative genomic analysis of Bacillus paralicheniformis MDJK30 with its closely related species reveals an evolutionary relationship between B. paralicheniformis and B. licheniformis

description: Table S3. List of 528 single-copy core genes shared by 56 Bacillus strains. (XLSX 37 kb)
DOI: 10.6084/m9.figshare.21617273.v1
title: Buried Jurassic rift system in the middle segment of the northern Qaidam Basin: Implications for Mesozoic landforms of the northern Tibetan Plateau

description: The Jurassic is one of the most important periods generating hydrocarbon source rocks and coals in Northwest China, and the Qaidam Basin is an important petroliferous and coal-forming basin. However, a series of explorations in the Qaidam Basin targeting Jurassic source rocks have failed over the past several years. These failures were mainly caused by missing the targeted Jurassic strata, suggesting that the current understanding of the Jurassic distribution in the Qaidam Basin is still limited. Therefore, this study conducts detailed analyses of the drilling wells and seismic data in the middle segment of the northern Qaidam Basin. The seismic profiles and borehole data indicate a rifting tectonic setting with discontinuous deposition and rapid facies transition during the Jurassic. A well-preserved buried rift valley proved in the Hongnan region reveals that the Jurassic deposits are mainly restricted in the narrow rift system. Therefore, further exploration targeting the Jurassic source rocks should focus on delineating the distribution of the Jurassic rift system in the Qaidam Basin, combined with the recovery of the complex Cenozoic tectonic overprinting.
DOI: 10.6084/m9.figshare.7986281
title: Additional file 4: of Comparative genomic analysis of Bacillus paralicheniformis MDJK30 with its closely related species reveals an evolutionary relationship between B. paralicheniformis and B. licheniformis

description: Table S2. Genetic characteristics of strains in the current research. (XLSX 15 kb)
DOI: 10.25549/usctheses-ouc11674110
title: Microsoft Word - OncoIngyadet_Diana_ExecutiveDissertation.docx
DOI: 10.25549/usctheses-c89-216207
title: 4-fact-sheet-latinos
DOI: 10.25549/usctheses-ouc11674883
title: Microsoft Word - GROWING WITH RESTRAINT.docx
DOI: 10.25549/usctheses-ouc11674916
title: Microsoft Word - Todd Mayhew - ASSISTING EMPLOYEES TO REDEPLOY INTO JOBS OF THE FUTURE 2-17-20.docx
DOI: 10.25549/usctheses-c89-288545
title: etd-StevensonA-8313
DOI: 10.6084/m9.figshare.7986335.v1
title: Additional file 1: of Genome-wide identification and expression profiling of trihelix gene family under abiotic stresses in wheat

description: Table S1. Characteristic features of trihelix genes in wheat and its relatives. Table S2. Coding sequences of trihelix genes in wheat and its relatives. Table S3. Amino acid sequences of trihelix proteins in wheat and its relatives. Table S4. Syntenic relationships of trihelix genes between wheat and its relatives. Table S5. Expression data of wheat trihelix genes for tissue-specific expression profile analyses. Table S6. Differential expression of wheat trihelix genes under cold and drought stresses. Table S7. Primers for qRT-PCR.
DOI: 10.25549/usctheses-c89-216204
title: Immigrants & mental health: A crisis looms