cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.7270/q2rx9bwz
title: BindingDB Entry 50027193: X-ray crystal structure of human heme oxygenase-1 in complex with 1-(adamantan-1-yl)-2-(1H-imidazol-1-yl)ethanone: a common binding mode for imidazole-based heme oxygenase-1 inhibitors.

description: Small molecule binding data for protein Heme Oxygenase 1 (HO-1), Uniprot P06762
DOI: 10.7270/q2s46rh7
title: BindingDB Entry 50017266: Synthesis and insecticidal activity of fluorinated 2-(2,6-dichloro-4-trifluoromethylphenyl)-2,4,5,6-tetrahydrocyclopentapyrazoles.

description: Small molecule binding data for protein GABA receptor subunit, Uniprot Q75NA5
DOI: 10.7270/q2sx6cwj
title: BindingDB Entry 50019589: Design, synthesis, and activity of 2-imidazol-1-ylpyrimidine derived inducible nitric oxide synthase dimerization inhibitors.

description: Small molecule binding data for protein Nitric oxide synthase, inducible, Uniprot P35228
DOI: 10.7270/q2w37w21
title: BindingDB Entry 50023584: Isoaurostatin, a novel topoisomerase inhibitor produced by Thermomonospora alba.

description: Small molecule binding data for protein Bacteriophage T4 DNA Ligase, CAM-RNase A, DNA topoisomerase, DNA topoisomerase 1, DNA topoisomerase I, DNA topoisomerase I (Topo I), Deoxyribonuclease-1, Deoxyribonuclease-2-alpha, Telomerase reverse transcriptase, Topoisomerase II alpha (HuTopoIIα), Type-2 restriction enzyme BamHI, Type-2 restriction enzyme EcoRI, Type-2 restriction enzyme HindIII, Type-2 restriction enzyme PstI, and Type-2 restriction enzyme ScaI, Uniprot O14746, O52691, O62855, P00639, P00640, P00642, P00970, P11387, P11388, P23940, P43870, P61823, Q04750, and Q7YR26
DOI: 10.7270/q2wq03f0
title: BindingDB Entry 50019610: M4 agonists/5HT7 antagonists with potential as antischizophrenic drugs: serominic compounds.

description: Small molecule binding data for protein 5-Hydroxytryptamine receptor 7 (5-HT7), Dopamine receptor D2L/neurotensin receptor NTS1, and Muscarinic acetylcholine receptor M2 and M4, Uniprot P08173, P14416, and P34969
DOI: 10.7270/q2wq03m7
title: BindingDB Entry 50027189: Synthesis of 1-arylpiperazyl-2-phenylcyclopropanes designed as antidopaminergic agents: cyclopropane-based conformationally restricted analogs of haloperidol.

description: Small molecule binding data for protein Dopamine receptor D2L/neurotensin receptor NTS1, Uniprot P14416
DOI: 10.7270/q2ws8svc
title: BindingDB Entry 50017265: Arylphthalazines. Part 2: 1-(Isoquinolin-5-yl)-4-arylamino phthalazines as potent inhibitors of VEGF receptors I and II.

description: Small molecule binding data for protein Vascular endothelial growth factor receptor 2, Uniprot P35968
DOI: 10.7270/q20g3jtz
title: BindingDB Entry 50019639: Novel class of arylpiperazines containing N-acylated amino acids: their synthesis, 5-HT1A, 5-HT2A receptor affinity, and in vivo pharmacological evaluation.

description: Small molecule binding data for protein Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor and Serotonin (5-HT) receptor, Uniprot P14842, P19327, and P61169
DOI: 10.7270/q20g3k0m
title: BindingDB Entry 50027215: Novel opioid peptide derived antagonists containing (2S)-2-methyl-3-(2,6-dimethyl-4-carbamoylphenyl)propanoic acid [(2S)-Mdcp].

description: Small molecule binding data for protein Delta-type opioid receptor, Nociceptin/mu opioid receptor, Opioid receptors; mu & delta, and mu/kappa opioid receptor, Uniprot P32300, P33533, P33535, P41144, and P97266
DOI: 10.7270/q23778kj
title: BindingDB Entry 50027240: Combining ligand-based pharmacophore modeling, quantitative structure-activity relationship analysis and in silico screening for the discovery of new potent hormone sensitive lipase inhibitors.

description: Small molecule binding data for protein Hormone-sensitive lipase (HSL), Uniprot P15304
DOI: 10.7270/q23j3crm
title: BindingDB Entry 50023722: A prolyl endopeptidase-inhibiting benzofuran dimer from Polyozellus multiflex.

description: Small molecule binding data for protein Elastase 1, Uniprot Q9UNI1
DOI: 10.7270/q24749jp
title: BindingDB Entry 50019635: 1-(5-Carboxy- and 5-carbamoylindol-1-yl)propan-2-ones as inhibitors of human cytosolic phospholipase A2alpha: bioisosteric replacement of the carboxylic acid and carboxamide moiety.

description: Small molecule binding data for protein cPLA2 C2, Uniprot P47712
DOI: 10.7270/q26973bz
title: BindingDB Entry 50023836: Bioactive abietane and seco-abietane diterpenoids from Salvia prionitis.

description: Small molecule binding data for protein DNA topoisomerase I, Uniprot Q04750
DOI: 10.7270/q2708198
title: BindingDB Entry 50027236: Synthesis and SAR of analogues of the M1 allosteric agonist TBPB. Part I: Exploration of alternative benzyl and privileged structure moieties.

description: Small molecule binding data for protein Dopamine receptor D2L/neurotensin receptor NTS1, Muscarinic acetylcholine receptor, Muscarinic acetylcholine receptor M1, Muscarinic acetylcholine receptor M1/M5 chimeric protein, Muscarinic acetylcholine receptor M2, and Muscarinic acetylcholine receptor M2 and M4, Uniprot P08172, P08173, P08912, P11229, P14416, and P20309
DOI: 10.7270/q280529v
title: BindingDB Entry 50019628: Calcitonin gene-related peptide analogues with aza and indolizidinone amino acid residues reveal conformational requirements for antagonist activity at the human calcitonin gene-related peptide 1 receptor.

description: Small molecule binding data for protein Calcitonin gene-related peptide type 1 receptor, Uniprot Q16602
DOI: 10.7270/q2b27v1v
title: BindingDB Entry 50023779: Haploscleridamine, a novel tryptamine-derived alkaloid from a sponge of the order haplosclerida: an inhibitor of cathepsin K.

description: Small molecule binding data for protein Cathepsin K, Uniprot P43235
DOI: 10.7270/q2br8s19
title: BindingDB Entry 50027231: Design, synthesis and structure-activity relationship of simple bis-amides as potent inhibitors of GlyT1.

description: Small molecule binding data for protein Cytochrome P450 2C9, Cytochrome P450 2D6 (2D6), Cytochrome P450 3A, Glycine transporter 1, and Glycine transporter 2, Uniprot P08684, P10635, P11712, P48067, and Q9Y345
DOI: 10.7270/q2cr5t2b
title: BindingDB Entry 50019621: Synthesis and biological study of 2-amino-4-aryl-5-chloropyrimidine analogues as inhibitors of VEGFR-2 and cyclin dependent kinase 1 (CDK1).

description: Small molecule binding data for protein Cyclin-dependent kinase 1 and Vascular endothelial growth factor receptor 2, Uniprot P06493 and P35968
DOI: 10.7270/q2ft8krv
title: BindingDB Entry 50023778: A new dimeric dihydrochalcone and a new prenylated flavone from the bud covers of Artocarpus altilis: potent inhibitors of cathepsin K.

description: Small molecule binding data for protein Cathepsin K, Uniprot P43235
DOI: 10.7270/q2gh9hs2
title: BindingDB Entry 50027228: Discovery of a highly orally bioavailable c-5-[6-(4-Methanesulfonyloxyphenyl)hexyl]-2-methyl-1,3-dioxane-r-2-carboxylic acid as a potent hypoglycemic and hypolipidemic agent.

description: Small molecule binding data for protein Peroxisome proliferator-activated receptor and Peroxisome proliferator-activated receptor alpha (PPAR alpha), Uniprot P37231 and Q07869
DOI: 10.7270/q2gm86wb
title: BindingDB Entry 50017286: Rational design and enantioselective synthesis of (1R,4S,5R,6S)-3-azabicyclo[3.3.0]octane-4,6-dicarboxylic acid - a novel inhibitor at human glutamate transporter subtypes 1, 2, and 3.

description: Small molecule binding data for protein Excitatory Amino Acid EAAT2, Excitatory amino acid transporter 1, Excitatory amino acid transporter 3, Metabotropic glutamate receptor 1, and Metabotropic glutamate receptor 2 (mGluR2), Uniprot P43003, P43004, P43005, Q13255, and Q14416
DOI: 10.7270/q2hh6jr6
title: BindingDB Entry 50019616: Pyrrolidino-tetrahydroisoquinolines as potent dual H3 antagonist and serotonin transporter inhibitors.

description: Small molecule binding data for protein Histamine receptor (H3) and Sodium-dependent serotonin transporter, Uniprot P31652 and Q9Y5N1
DOI: 10.7270/q2kk9bh1
title: BindingDB Entry 50023777: Two new furanoditerpenes from Saururus chinenesis and their effects on the activation of peroxisome proliferator-activated receptor gamma.

description: Small molecule binding data for protein Peroxisome proliferator-activated receptor, Uniprot P37231
DOI: 10.7270/q2m61k31
title: BindingDB Entry 50027223: Small, non-peptide C5a receptor antagonists: part 2.

description: Small molecule binding data for protein C5a anaphylatoxin chemotactic receptor (C5aR), Uniprot P21730
DOI: 10.7270/q2mc8zmp
title: BindingDB Entry 50017284: Inhibition of cytosolic phospholipase A2alpha: hit to lead optimization.

description: Small molecule binding data for protein cPLA2 C2, Uniprot P47712
DOI: 10.7270/q2n58m15
title: BindingDB Entry 50019612: Synthesis and in vitro evaluation of tetrahydroisoquinolinyl benzamides as ligands for sigma receptors.

description: Small molecule binding data for protein Sigma-1 receptor, Uniprot Q60492
DOI: 10.7270/q2qc0379
title: BindingDB Entry 50023759: New antiinfective and human 5-HT2 receptor binding natural and semisynthetic compounds from the Jamaican sponge Smenospongia aurea.

description: Small molecule binding data for protein 5-Hydroxytryptamine receptor 2A (5-HT2A), 5-Hydroxytryptamine receptor 2C (5-HT2C), and Plasmepsin 2, Uniprot P28223, P28335, and P46925
DOI: 10.7270/q2qz29ns
title: BindingDB Entry 50019651: From five- to six-membered rings: 3,4-diarylquinolinone as lead for novel p38MAP kinase inhibitors.

description: Small molecule binding data for protein Mitogen-activated protein kinase 10 and Mitogen-activated protein kinase 14, Uniprot P53779 and Q16539
DOI: 10.7270/q2qz29sk
title: BindingDB Entry 50027217: Total synthesis and biological evaluation of the marine bromopyrrole alkaloid dispyrin: elucidation of discrete molecular targets with therapeutic potential.

description: Small molecule binding data for protein Alpha-1D adrenergic receptor, Alpha-2A adrenergic receptor, HRH3, and Histamine H3 receptor, Uniprot P08913, P25100, Q9JI35, and Q9QYN8
DOI: 10.7270/q2r49qbd
title: BindingDB Entry 50017283: Synthesis and in vivo validation of [O-methyl-11C]2-{4-[4-(7-methoxynaphthalen-1-yl)piperazin- 1-yl]butyl}-4-methyl-2H-[1,2,4]triazine-3,5-dione: a novel 5-HT1A receptor agonist positron emission tomography ligand.

description: Small molecule binding data for protein 5-Hydroxytryptamine receptor 2A (5-HT2A), 5-Hydroxytryptamine receptor 2C (5-HT2C), 5-Hydroxytryptamine receptor 6 (5-HT6), 5-Hydroxytryptamine receptor 7 (5-HT7), 5-hydroxytryptamine receptor 1A, Adenosine A2 receptor, Adenosine receptor A2a, Adenosine receptor A3, Adrenergic receptor alpha-1, Alpha-2A adrenergic receptor, Alpha-2B adrenergic receptor, Alpha-2C adrenergic receptor, Beta-1 adrenergic receptor, Beta-2 adrenergic receptor and beta-3 adrenergic receptor, Beta-3 adrenergic receptor, Cannabinoid receptor 1, Cannabinoid receptor 2, Delta-type opioid receptor, Dopamine D1 and D2 receptor, Dopamine D5 receptor, Dopamine receptor, Dopamine receptor D2L/neurotensin receptor NTS1, Dopamine receptors; D2 & D4, Histamine H1 receptor, Histamine H2 Receptor, Histamine receptor (H3), Histamine receptor (H4), Kappa-type opioid receptor, Low affinity neurotrophin receptor p75NTR, Mu-type opioid receptor, Muscarinic acetylcholine receptor, P-glycoprotein 1, Serotonin (5-HT) receptor, Serotonin and norepinephrine transporters (SERT/NET), Sigma, Sodium-dependent dopamine transporter, Sodium-dependent noradrenaline transporter, Synaptic vesicular amine transporter, Vasopressin V1 receptor, Vasopressin V2 receptor (V2), Vesicular amine transporter 1, and Voltage-gated potassium channel, Uniprot P07550, P08138, P08172, P08173, P08183, P08588, P08908, P08912, P08913, P0DMS8, P11229, P13945, P14416, P18089, P18825, P20309, P21554, P21728, P21917, P21918, P23975, P25021, P25100, P28223, P28335, P29274, P29275, P30518, P31645, P34969, P34972, P35348, P35367, P35368, P35372, P35462, P37288, P41143, P41145, P47898, P47901, P50406, P54219, Q01959, Q05940, Q12809, Q4W594, Q99720, Q9H3N8, and Q9Y5N1
DOI: 10.7270/q2v40tz7
title: BindingDB Entry 50023743: Cyclotheonamide E4 and E5, new potent tryptase inhibitors from an Ircinia species of sponge.

description: Small molecule binding data for protein Prothrombin, Uniprot P00734
DOI: 10.7270/q2vq32b2
title: BindingDB Entry 50019645: Identification, synthesis, and biological evaluation of novel pyrazoles as low molecular weight luteinizing hormone receptor agonists.

description: Small molecule binding data for protein Luteinizing hormone/Choriogonadotropin receptor, Uniprot P22888
DOI: 10.7270/q2vq32h9
title: BindingDB Entry 50027216: A beta-fluoroamine inhibitor of purine nucleoside phosphorylase.

description: Small molecule binding data for protein Purine Nucleoside Phosphorylase (PNP) and Purine nucleoside phosphorylase, Uniprot P00491
DOI: 10.7270/q2vx0g2c
title: BindingDB Entry 50017282: Discovery of nonpeptidic small-molecule AP-1 inhibitors: lead hopping based on a three-dimensional pharmacophore model.

description: Small molecule binding data for protein Proto-oncogene c-JUN/protein c-fos, Uniprot P01100, P05412, and Q6FG41
DOI: 10.7270/q2zg6s38
title: BindingDB Entry 50027245: Analogues of 2-phenyl-ethenesulfonic acid phenyl ester have dual functions of inhibiting expression of inducible nitric oxide synthase and activating peroxisome proliferator-activated receptor gamma.

description: Small molecule binding data for protein Peroxisome proliferator-activated receptor, Uniprot P37231
DOI: 10.7270/q2zw1kn6
title: BindingDB Entry 50023736: New sugar-mimic alkaloids from the pods of Angylocalyx pynaertii.

description: Small molecule binding data for protein α-galactosidase, β-galactosidase, Acidic alpha-glucosidase, Alpha-L-fucosidase 1, Alpha-glucosidase MAL62, Beta-mannosidase, and alpha-Glucosidase (α-Glucosidase), Uniprot P07265, P23739, Q2KIM0, Q42656, Q4FZV0, Q58D55, and Q6P7A9
DOI: 10.7270/q22807fq
title: BindingDB Entry 50027256: Modified peptides as potent inhibitors of the postsynaptic density-95/N-methyl-D-aspartate receptor interaction.

description: Small molecule binding data for protein Disks large homolog 4, Uniprot P78352
DOI: 10.7270/q22n521z
title: BindingDB Entry 50023839: Agonodepsides a and B: two new depsides from a filamentous fungus F7524.

description: Small molecule binding data for protein Enoyl-ACP Reductase (InhA), Uniprot P9WGR1
DOI: 10.7270/q23778cv
title: BindingDB Entry 50019682: Thienopyrimidinone bis-aminopyrrolidine ureas as potent melanin-concentrating hormone receptor-1 (MCH-R1) antagonists.

description: Small molecule binding data for protein Cytochrome P450 2D6 (2D6) and Melanin-concentrating hormone receptor, Uniprot P10635 and Q99705
DOI: 10.7270/q25d8rmh
title: BindingDB Entry 50023927: Triterpenoid constituents isolated from the bark of Abies sachalinensis.

description: Small molecule binding data for protein Topoisomerase II alpha (HuTopoIIα), Uniprot P11388
DOI: 10.7270/q261105f
title: BindingDB Entry 50027254: Identification of a nonbasic, nitrile-containing cathepsin K inhibitor (MK-1256) that is efficacious in a monkey model of osteoporosis.

description: Small molecule binding data for protein Cathepsin K, Uniprot P43236
DOI: 10.7270/q270813k
title: BindingDB Entry 50019681: Understanding the structural requirements of 4-anilidopiperidine analogues for biological activities at mu and delta opioid receptors.

description: Small molecule binding data for protein Delta-type opioid receptor, Nociceptin/mu opioid receptor, and mu/kappa opioid receptor, Uniprot P33535, P41143, and P97266
DOI: 10.7270/q2959h9s
title: BindingDB Entry 50023911: Antioxidant and free-radical scavenging activity of constituents of the leaves of Tachigalia paniculata.

description: Small molecule binding data for protein Xanthine oxidase, Uniprot P47989
DOI: 10.7270/q29s1qw2
title: BindingDB Entry 50027252: Toward optimization of the linker substructure common to transthyretin amyloidogenesis inhibitors using biochemical and structural studies.

description: Small molecule binding data for protein Cyclooxygenase-1 (COX-1), Uniprot P23219
DOI: 10.7270/q2br8rvn
title: BindingDB Entry 50019675: Synthesis and biological evaluation of [18F]bicalutamide, 4-[76Br]bromobicalutamide, and 4-[76Br]bromo-thiobicalutamide as non-steroidal androgens for prostate cancer imaging.

description: Small molecule binding data for protein Androgen receptor, Uniprot P15207
DOI: 10.7270/q2dv1jng
title: BindingDB Entry 50023910: Screening of ubiquitous plant constituents for COX-2 inhibition with a scintillation proximity based assay.

description: Small molecule binding data for protein Cyclooxygenase and Cyclooxygenase-1 (COX-1), Uniprot P23219 and P35354
DOI: 10.7270/q2fj2gms
title: BindingDB Entry 50027251: Structure-activity relationships of 1,4-dihydropyridines that act as enhancers of the vanilloid receptor 1 (TRPV1).

description: Small molecule binding data for protein Adenosine receptor A3, Transient receptor potential cation channel subfamily V member 1, and Vanilloid receptor, Uniprot O35433, P0DMS8, and Q8NER1
DOI: 10.7270/q2gh9hn8
title: BindingDB Entry 50019674: Novel sigma receptor ligands: synthesis and biological profile.

description: Small molecule binding data for protein 5-Hydroxytryptamine receptor 2C (5-HT2C), DOPAMINE, Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor, Dopamine Transporter (DAT), Dopamine receptor, HTR4, HTR6, Histamine H1 receptor, Serotonin (5-HT) receptor, Sigma-1 receptor, and Sodium-dependent serotonin transporter, Uniprot O70528, P14842, P18901, P19020, P23977, P28335, P31388, P31390, P31652, P35563, P61169, and Q60492
DOI: 10.7270/q2jm29c6
title: BindingDB Entry 50023905: Lignans isolated from valerian: identification and characterization of a new olivil derivative with partial agonistic activity at A(1) adenosine receptors.

description: Small molecule binding data for protein Adenosine Receptors A2a (A2a) and Adenosine receptor A1, Uniprot P25099, P30542, and P30543
DOI: 10.7270/q2k9376q
title: BindingDB Entry 50019702: Novel N-substituted indol-3-ylglyoxylamides probing the LDi and L1/L2 lipophilic regions of the benzodiazepine receptor site in search for subtype-selective ligands.

description: Small molecule binding data for protein GABA receptor alpha-1/beta-2/gamma-2 subunit, GABA receptor alpha-2/beta-2/gamma-2 subunit, and GABA receptor alpha-5/beta-3/gamma-2 subunit, Uniprot P18508, P19969, P23576, P62813, P63079, and P63138
DOI: 10.7270/q2k937bh
title: BindingDB Entry 50027250: Mycophenolic acid analogs with a modified metabolic profile.

description: Small molecule binding data for protein Inosine Monophosphate Dehydrogenase Type 1 (IMPDH1) and Inosine Monophosphate Dehydrogenase Type 2 (IMPDH2), Uniprot P12268 and P20839
DOI: 10.7270/q2m908b3
title: BindingDB Entry 50019672: Novel selective inhibitors of the zinc plasmodial aminopeptidase PfA-M1 as potential antimalarial agents.

description: Small molecule binding data for protein Aminopeptidase N and Zinc aminopeptidase, Uniprot O96935 and P15145
DOI: 10.7270/q2pc324c
title: BindingDB Entry 50023900: Constituents of the stigmas of Crocus sativus and their tyrosinase inhibitory activity.

description: Small molecule binding data for protein Tyrosinase, Uniprot O42713
DOI: 10.7270/q2pz58pn
title: BindingDB Entry 50027247: Design and synthesis of 6-phenylnicotinamide derivatives as antagonists of TRPV1.

description: Small molecule binding data for protein Cytochrome P450 3A, Transient receptor potential cation channel subfamily V member 1, Vanilloid receptor, and Vanilloid receptor 1, Uniprot O35433, P08684, Q6R5A3, and Q8NER1
DOI: 10.7270/q2sq907j
title: BindingDB Entry 50027260: Using proton nuclear magnetic resonance to study the mode of ribonuclease A inhibition by competitive and noncompetitive inhibitors.

description: Small molecule binding data for protein RNAse A, Uniprot P07998
DOI: 10.7270/q2t43sv9
title: BindingDB Entry 50023853: New flavonol oligoglycosides and polyacylated sucroses with inhibitory effects on aldose reductase and platelet aggregation from the flowers of Prunus mume.

description: Small molecule binding data for protein Aldose reductase, Uniprot P07943
DOI: 10.15156/bio/sh0933909.10fu
title: SH0933909.10FU

description: UNITE provides a unified way for delimiting, identifying, communicating, and working with DNA-based Species Hypotheses (SH). All fungal ITS sequences in the international nucleotide sequence databases are clustered to approximately the species level by applying a set of dynamic distance values (<0.5 - 3.0%). All species hypotheses are given a unique, stable name in the form of a DOI, and their taxonomic and ecological annotations are verified through distributed, web-based third-party annotation efforts. SHs are connected to a taxon name and its classification as far as possible (phylum, class, order, etc.) by taking into account identifications for all sequences in the SH. An automatically or manually designated sequence is chosen to represent each such SH. These sequences are released (https://unite.ut.ee/repository.php) for use by the scientific community in, for example, local sequence similarity searches and next-generation sequencing analysis pipelines. The system and the data are updated automatically as the number of public fungal ITS sequences grows.
DOI: 10.15156/bio/sh0933910.10fu
title: SH0933910.10FU

description: UNITE provides a unified way for delimiting, identifying, communicating, and working with DNA-based Species Hypotheses (SH). All fungal ITS sequences in the international nucleotide sequence databases are clustered to approximately the species level by applying a set of dynamic distance values (<0.5 - 3.0%). All species hypotheses are given a unique, stable name in the form of a DOI, and their taxonomic and ecological annotations are verified through distributed, web-based third-party annotation efforts. SHs are connected to a taxon name and its classification as far as possible (phylum, class, order, etc.) by taking into account identifications for all sequences in the SH. An automatically or manually designated sequence is chosen to represent each such SH. These sequences are released (https://unite.ut.ee/repository.php) for use by the scientific community in, for example, local sequence similarity searches and next-generation sequencing analysis pipelines. The system and the data are updated automatically as the number of public fungal ITS sequences grows.
DOI: 10.15156/bio/sh0933911.10fu
title: SH0933911.10FU

description: UNITE provides a unified way for delimiting, identifying, communicating, and working with DNA-based Species Hypotheses (SH). All fungal ITS sequences in the international nucleotide sequence databases are clustered to approximately the species level by applying a set of dynamic distance values (<0.5 - 3.0%). All species hypotheses are given a unique, stable name in the form of a DOI, and their taxonomic and ecological annotations are verified through distributed, web-based third-party annotation efforts. SHs are connected to a taxon name and its classification as far as possible (phylum, class, order, etc.) by taking into account identifications for all sequences in the SH. An automatically or manually designated sequence is chosen to represent each such SH. These sequences are released (https://unite.ut.ee/repository.php) for use by the scientific community in, for example, local sequence similarity searches and next-generation sequencing analysis pipelines. The system and the data are updated automatically as the number of public fungal ITS sequences grows.