DOI: 10.7270/q2h41vgn
title: BindingDB Entry 50006482: Identification of N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide (PIM447), a Potent and Selective Proviral Insertion Site of Moloney Murine Leukemia (PIM) 1, 2, and 3 Kinase Inhibitor in Clinical Trials for Hematological Malignancies.

description: Small molecule binding data for protein 1,3-beta-glucan synthase component GLS2, 3-phosphoinositide dependent protein kinase-1, ALK tyrosine kinase receptor, Aurora kinase A/Targeting protein for Xklp2, Axin-1/Glycogen synthase kinase-3 beta, CAMK2B, CDK2/Cyclin A1, COUP transcription factor 1, Calmodulin/Proto-oncogene tyrosine-protein kinase Src, Casein kinase I isoform alpha, Cereblon/BCR/ABL, Cyclin-Dependent Kinase 1 (CDK1), Cyclin-Dependent Kinase 4 (CDK4), Dual specificity mitogen-activated protein kinase kinase 1/Mitogen-activated protein kinase 1/RAF proto-oncogene serine/threonine-protein kinase, Ephrin receptor, Ephrin type-B receptor 4, Fibroblast growth factor receptor 1, Fibroblast growth factor receptor 2, Fibroblast growth factor receptor 3, Fibroblast growth factor receptor 4, Focal adhesion kinase 1/vascular endothelial growth factor receptor 3, Hepatocyte growth factor receptor, Insulin receptor, Insulin-like growth factor I receptor, Interleukin-1 receptor-associated kinase 4, JAK1/TYK2, JAK3/JAK1, JNK2/JNK3, MAP kinase-activated protein kinase 2, MAP kinase-activated protein kinase 5, MAP kinase-interacting serine/threonine-protein kinase 1/2, MER intracellular domain/EGFR extracellular domain chimera, Macrophage-stimulating protein receptor, Mast/stem cell growth factor receptor Kit, Mitogen-activated protein kinase 10, Mitogen-activated protein kinase 12, Non-receptor tyrosine-protein kinase TYK2, PIK3CG/PIK3R1, PKC alpha and beta-2, Phosphatidylinositol 3-kinase catalytic subunit type 3, Phosphatidylinositol 3-kinase regulatory subunit beta/Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform/[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform, Phosphatidylinositol 4-kinase, PI4K, Platelet-derived growth factor receptor, Protein kinase C theta type, Protein kinase N1, Protein kinase N2, Proto-oncogene tyrosine-protein kinase receptor Ret, RAC-alpha serine/threonine-protein kinase AKT1, Receptor protein-tyrosine kinase erbB-4, Receptor tyrosine-protein kinase erbB-2, Rho-associated protein kinase, SRC, Serine/threonine-protein kinase PAK 2, Serine/threonine-protein kinase PLK1, Serine/threonine-protein kinase WNK1, Serine/threonine-protein kinase pim-1, Serine/threonine-protein kinase pim-2, Serine/threonine-protein kinase pim-3, Tyrosine-protein kinase BTK, Tyrosine-protein kinase CSK, Tyrosine-protein kinase Fyn, Tyrosine-protein kinase HCK, Tyrosine-protein kinase JAK2, Tyrosine-protein kinase SYK, Tyrosine-protein kinase Yes, Tyrosine-protein kinase ZAP-70, Tyrosine-protein kinase receptor FLT3, Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2), mTOR/FKBP12A/FKBP12B, and p38 MAP kinase alpha/beta, Uniprot A0A024QYW7, A0A024R244, A0A024R720, A0A024R759, A0A024R7E4, A0A024R7M7, A0A024R7T2, A0A024R8E2, A0A024RB77, A0A024RBB6, A0A024RD15, A0A024RD25, A0A0S2Z3Y8, A0A2K8FKV1, A0A2P9DU05, A1MA61, A4D2J9, B0LPE5, B2R6Q4, L7RSM7, O00329, O14965, O15530, O60674, O75116, P00519, P00533, P04626, P06213, P06239, P06241, P06493, P07947, P07948, P07949, P08069, P08581, P08631, P10589, P10721, P11309, P11362, P11802, P12931, P14635, P16234, P17252, P21802, P22455, P22607, P23458, P24385, P24941, P28482, P29597, P31749, P35968, P36888, P40989, P41240, P42336, P42338, P42345, P43403, P43405, P45984, P48729, P48736, P49137, P49841, P52333, P53350, P53778, P53779, P54760, P54764, P78396, Q04759, Q04912, Q05397, Q06187, Q13177, Q13554, Q15303, Q16512, Q16513, Q16539, Q1HBJ4, Q541P7, Q69FE3, Q6FI00, Q6FI27, Q86V86, Q8IW41, Q8NEB9, Q9BUB5, Q9H4A3, Q9HBH9, Q9NWZ3, Q9P1W9, Q9UBF8, Q9UM73, and X5DNK3