cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.25242973
title: README

description: This file denotes the abstract of the article along with the methods of the data collection process. In the data collection, it covers details of how data was collected, who were the targeted informants, and how the data was analyzed using the Nvivo 14 software (to derive the code)
DOI: 10.6084/m9.figshare.25242973.v1
title: README

description: This file denotes the abstract of the article along with the methods of the data collection process. In the data collection, it covers details of how data was collected, who were the targeted informants, and how the data was analyzed using the Nvivo 14 software (to derive the code)
DOI: 10.6084/m9.figshare.12386450
title: Additional file 8 of Alterations of gut microbiome accelerate multiple myeloma progression by increasing the relative abundances of nitrogen-recycling bacteria

description: Additional file 8: Table S3. The differential KOs identified by DESeq2 [|log2(Fold Change)|&gt;1 & adjusted P&lt;0.05]. The KOs with log2FoldChange more than 1 suggest MM-enriched.
DOI: 10.6084/m9.figshare.12386450.v1
title: Additional file 8 of Alterations of gut microbiome accelerate multiple myeloma progression by increasing the relative abundances of nitrogen-recycling bacteria

description: Additional file 8: Table S3. The differential KOs identified by DESeq2 [|log2(Fold Change)|&gt;1 & adjusted P&lt;0.05]. The KOs with log2FoldChange more than 1 suggest MM-enriched.
DOI: 10.48677/1fd59900-39c6-48b1-8efe-fbfe315c80a2
title: Kartographisches Modell 1:250 000 Vektor Stichtag 01.07.2021

description: Das KM250-V umfasst den Inhalt des Kartographischen Modells 1:200 000 - Raster (KM200-R) in Vektorform, jedoch nur vom Bundesgebiet und generalisiert entsprechend dem Maßstab 1:250 000.
Österreichs Anteil am paneuropäischen Datensatz EuroRegionalMap (ERM) wird davon abgeleitet.
Die vom KM250-V abgeleitete, staatliche Österreichische Karte 1:250 000 (ÖK250) wird in Kooperation mit dem Bundesministerium für Landesverteidigung (BMLV) gedruckt.

Das KM250-V ist in folgende Objektbereiche gegliedert:
• Verkehr
• Gewässer
• Raumgliederung
• Siedlung
• Höhenschichtlinien (inkl. Attribute)
• Bodenbedeckung
• Einzelsignaturen
• Namen

Stichtag = Erstellungsdatum:
Die Daten sind zu diesem Tag der aktuellste Datenbestand des BEV.
Dies ist nicht ident mit dem Aufnahme- bzw. Vermessungsdatum.
DOI: 10.25835/wasieu9f
title: Experiences and Challenges of Recovery Codes for an End-to-End Encrypted Service

description: The replication package for the paper: A Mixed-Methods Study on User Experiences and Challenges of Recovery Codes for
an End-to-End Encrypted Service
DOI: 10.6084/m9.figshare.21299371
title: Additional file 1 of Comprehensive ceRNA network for MACF1 regulates osteoblast proliferation

description: Supplementary Material 1
DOI: 10.6084/m9.figshare.21299371.v1
title: Additional file 1 of Comprehensive ceRNA network for MACF1 regulates osteoblast proliferation

description: Supplementary Material 1
DOI: 10.6084/m9.figshare.21299383
title: Additional file 1 of TIMM8A is associated with dysfunction of immune cell in BRCA and UCEC for predicting anti-PD-L1 therapy efficacy

description: Additional file 1. Raw measurements of survival time of UCEC patients and their TIMM8A expression levels. The raw data showed that the prognosis of the high expression group (FPKM value higher than 2.15) was poorer than the low expression group (FPKM value lower than 2.15).
DOI: 10.6084/m9.figshare.21299383.v1
title: Additional file 1 of TIMM8A is associated with dysfunction of immune cell in BRCA and UCEC for predicting anti-PD-L1 therapy efficacy

description: Additional file 1. Raw measurements of survival time of UCEC patients and their TIMM8A expression levels. The raw data showed that the prognosis of the high expression group (FPKM value higher than 2.15) was poorer than the low expression group (FPKM value lower than 2.15).
DOI: 10.6084/m9.figshare.21823673
title: Long non-coding RNA DNMBP-AS1 promotes prostate cancer development by regulating LCLAT1

description: Prostate cancer (PCa) is as a serious threat to male’s health around the world. Recent studies have indicated that long non-coding RNAs (lncRNAs) occupy an important position in various human cancers. However, the function and mechanism of lncRNA DNMBP antisense RNA 1 (DNMBP-AS1) in PCa is rarely investigated. RT-qPCR analysis was used to test gene expression. CCK-8, colony formation, EdU staining and transwell assays were conducted to assess the function of DNMBP-AS1 on PCa cell behaviors. RNA pull down, RIP and luciferase reporter assays were implemented to verify the mechanism of DNMBP-AS1. DNMBP-AS1 was obviously up-regulated in PCa cell lines. Functionally, DNMBP-AS1 knockdown weakened cell proliferation, migration and invasion of PCa. Mechanistically, DNMBP-AS1 sponged microRNA-6766-3p (miR-6766-3p) to regulate lysocardiolipin acyltransferase 1 (LCLAT1) expression. Furthermore, DNMBP-AS1 could stabilize LCLAT1 expression by recruiting ELAV like RNA binding protein 1 (ELAVL1). Consequently, rescue assays demonstrated that DNMBP-AS1 regulated PCa cell proliferation, migration and invasion through enhancing LCLAT1 expression. Collectively, we elucidated the function and regulatory mechanism of DNMBP-AS1 and provided the first evidence of DNMBP-AS1 as a driver for PCa.
DOI: 10.6084/m9.figshare.21823673.v1
title: Long non-coding RNA DNMBP-AS1 promotes prostate cancer development by regulating LCLAT1

description: Prostate cancer (PCa) is as a serious threat to male’s health around the world. Recent studies have indicated that long non-coding RNAs (lncRNAs) occupy an important position in various human cancers. However, the function and mechanism of lncRNA DNMBP antisense RNA 1 (DNMBP-AS1) in PCa is rarely investigated. RT-qPCR analysis was used to test gene expression. CCK-8, colony formation, EdU staining and transwell assays were conducted to assess the function of DNMBP-AS1 on PCa cell behaviors. RNA pull down, RIP and luciferase reporter assays were implemented to verify the mechanism of DNMBP-AS1. DNMBP-AS1 was obviously up-regulated in PCa cell lines. Functionally, DNMBP-AS1 knockdown weakened cell proliferation, migration and invasion of PCa. Mechanistically, DNMBP-AS1 sponged microRNA-6766-3p (miR-6766-3p) to regulate lysocardiolipin acyltransferase 1 (LCLAT1) expression. Furthermore, DNMBP-AS1 could stabilize LCLAT1 expression by recruiting ELAV like RNA binding protein 1 (ELAVL1). Consequently, rescue assays demonstrated that DNMBP-AS1 regulated PCa cell proliferation, migration and invasion through enhancing LCLAT1 expression. Collectively, we elucidated the function and regulatory mechanism of DNMBP-AS1 and provided the first evidence of DNMBP-AS1 as a driver for PCa.
DOI: 10.48677/e8e42197-e72a-4455-b070-aebd874f2ec4
title: Kartographisches Modell 1:500 000 Vektor Stichtag 01.07.2021

description: Das Kartographische Modell 1:500 000 - Vektor (KM500-V) beinhaltet die maßstabsbezogenen generalisierten Vektordaten der topographischen Übersichtskarte von Österreich im Maßstab 1:500 000.

Das KM500-V ist in folgende Objektbereiche gegliedert:
• Bodenbedeckung (Waldfläche und Felsen)
• Geländedarstellung
• Gewässer
• Grenzen (Verwaltung, natürliche und kulturelle Raumgliederung)
• Siedlung
• Verkehr

Stichtag = Erstellungsdatum:
Die Daten sind zu diesem Tag der aktuellste Datenbestand des BEV.
Dies ist nicht ident mit dem Aufnahme- bzw. Vermessungsdatum.
DOI: 10.6084/m9.figshare.17105151
title: NlML2.pdb from An MD-2-related lipid-recognition protein is required for insect reproduction and integument development

description: The myeloid differentiation factor 2 (MD-2)-related lipid-recognition protein is involved in immune responses through recognizing bacteria lipopolysaccharide in mammals, arthropods and plants. However, the physiological roles of MD-2 in other biological processes are largely unknown. Here, we identified three homologue MD-2 genes (<i>NlML1</i>, <i>NlML2</i> and <i>NlML3</i>) by searching the genome and transcriptome databases of the brown planthopper <i>Nilaparvata lugens</i>, a hemipteran insect species. Temporospatial analysis showed that the <i>NlML1</i> gene was highly expressed in the fat body but lowly expressed in the other tissues, while the <i>NlML2</i> and <i>NlML3</i> genes were highly expressed in the testis or digestive tract. RNA interference-mediated depletion of the <i>NlML1</i> gene significantly downregulated the transcription of numerous integument protein genes. The <i>NlML1</i> knockdown led to moulting failure and mortality at the nymph–adult transition phase, impaired egg laying and hatching and reduced 20-hydroxyecdysone (20E) production in the nymphs. 20E could rescue the deficient moulting phenotypes derived from ds<i>NlML1</i> RNAi. These novel findings indicate that <i>NlML1</i> is required for nymphal moulting and female reproductive success—as it plays an important role in regulating 20E synthesis, lipid and chitin metabolisms in <i>N. lugens</i>—thus contributing to our understanding of developmental and reproductive mechanisms in insects.
DOI: 10.6084/m9.figshare.17105151.v1
title: NlML2.pdb from An MD-2-related lipid-recognition protein is required for insect reproduction and integument development

description: The myeloid differentiation factor 2 (MD-2)-related lipid-recognition protein is involved in immune responses through recognizing bacteria lipopolysaccharide in mammals, arthropods and plants. However, the physiological roles of MD-2 in other biological processes are largely unknown. Here, we identified three homologue MD-2 genes (<i>NlML1</i>, <i>NlML2</i> and <i>NlML3</i>) by searching the genome and transcriptome databases of the brown planthopper <i>Nilaparvata lugens</i>, a hemipteran insect species. Temporospatial analysis showed that the <i>NlML1</i> gene was highly expressed in the fat body but lowly expressed in the other tissues, while the <i>NlML2</i> and <i>NlML3</i> genes were highly expressed in the testis or digestive tract. RNA interference-mediated depletion of the <i>NlML1</i> gene significantly downregulated the transcription of numerous integument protein genes. The <i>NlML1</i> knockdown led to moulting failure and mortality at the nymph–adult transition phase, impaired egg laying and hatching and reduced 20-hydroxyecdysone (20E) production in the nymphs. 20E could rescue the deficient moulting phenotypes derived from ds<i>NlML1</i> RNAi. These novel findings indicate that <i>NlML1</i> is required for nymphal moulting and female reproductive success—as it plays an important role in regulating 20E synthesis, lipid and chitin metabolisms in <i>N. lugens</i>—thus contributing to our understanding of developmental and reproductive mechanisms in insects.
DOI: 10.6084/m9.figshare.17105154
title: Supplementary Table.xls from An MD-2-related lipid-recognition protein is required for insect reproduction and integument development

description: The myeloid differentiation factor 2 (MD-2)-related lipid-recognition protein is involved in immune responses through recognizing bacteria lipopolysaccharide in mammals, arthropods and plants. However, the physiological roles of MD-2 in other biological processes are largely unknown. Here, we identified three homologue MD-2 genes (<i>NlML1</i>, <i>NlML2</i> and <i>NlML3</i>) by searching the genome and transcriptome databases of the brown planthopper <i>Nilaparvata lugens</i>, a hemipteran insect species. Temporospatial analysis showed that the <i>NlML1</i> gene was highly expressed in the fat body but lowly expressed in the other tissues, while the <i>NlML2</i> and <i>NlML3</i> genes were highly expressed in the testis or digestive tract. RNA interference-mediated depletion of the <i>NlML1</i> gene significantly downregulated the transcription of numerous integument protein genes. The <i>NlML1</i> knockdown led to moulting failure and mortality at the nymph–adult transition phase, impaired egg laying and hatching and reduced 20-hydroxyecdysone (20E) production in the nymphs. 20E could rescue the deficient moulting phenotypes derived from ds<i>NlML1</i> RNAi. These novel findings indicate that <i>NlML1</i> is required for nymphal moulting and female reproductive success—as it plays an important role in regulating 20E synthesis, lipid and chitin metabolisms in <i>N. lugens</i>—thus contributing to our understanding of developmental and reproductive mechanisms in insects.
DOI: 10.6084/m9.figshare.17105154.v1
title: Supplementary Table.xls from An MD-2-related lipid-recognition protein is required for insect reproduction and integument development

description: The myeloid differentiation factor 2 (MD-2)-related lipid-recognition protein is involved in immune responses through recognizing bacteria lipopolysaccharide in mammals, arthropods and plants. However, the physiological roles of MD-2 in other biological processes are largely unknown. Here, we identified three homologue MD-2 genes (<i>NlML1</i>, <i>NlML2</i> and <i>NlML3</i>) by searching the genome and transcriptome databases of the brown planthopper <i>Nilaparvata lugens</i>, a hemipteran insect species. Temporospatial analysis showed that the <i>NlML1</i> gene was highly expressed in the fat body but lowly expressed in the other tissues, while the <i>NlML2</i> and <i>NlML3</i> genes were highly expressed in the testis or digestive tract. RNA interference-mediated depletion of the <i>NlML1</i> gene significantly downregulated the transcription of numerous integument protein genes. The <i>NlML1</i> knockdown led to moulting failure and mortality at the nymph–adult transition phase, impaired egg laying and hatching and reduced 20-hydroxyecdysone (20E) production in the nymphs. 20E could rescue the deficient moulting phenotypes derived from ds<i>NlML1</i> RNAi. These novel findings indicate that <i>NlML1</i> is required for nymphal moulting and female reproductive success—as it plays an important role in regulating 20E synthesis, lipid and chitin metabolisms in <i>N. lugens</i>—thus contributing to our understanding of developmental and reproductive mechanisms in insects.
DOI: 10.6084/m9.figshare.17105157
title: NlML1.pdb from An MD-2-related lipid-recognition protein is required for insect reproduction and integument development

description: The myeloid differentiation factor 2 (MD-2)-related lipid-recognition protein is involved in immune responses through recognizing bacteria lipopolysaccharide in mammals, arthropods and plants. However, the physiological roles of MD-2 in other biological processes are largely unknown. Here, we identified three homologue MD-2 genes (<i>NlML1</i>, <i>NlML2</i> and <i>NlML3</i>) by searching the genome and transcriptome databases of the brown planthopper <i>Nilaparvata lugens</i>, a hemipteran insect species. Temporospatial analysis showed that the <i>NlML1</i> gene was highly expressed in the fat body but lowly expressed in the other tissues, while the <i>NlML2</i> and <i>NlML3</i> genes were highly expressed in the testis or digestive tract. RNA interference-mediated depletion of the <i>NlML1</i> gene significantly downregulated the transcription of numerous integument protein genes. The <i>NlML1</i> knockdown led to moulting failure and mortality at the nymph–adult transition phase, impaired egg laying and hatching and reduced 20-hydroxyecdysone (20E) production in the nymphs. 20E could rescue the deficient moulting phenotypes derived from ds<i>NlML1</i> RNAi. These novel findings indicate that <i>NlML1</i> is required for nymphal moulting and female reproductive success—as it plays an important role in regulating 20E synthesis, lipid and chitin metabolisms in <i>N. lugens</i>—thus contributing to our understanding of developmental and reproductive mechanisms in insects.
DOI: 10.6084/m9.figshare.17105157.v1
title: NlML1.pdb from An MD-2-related lipid-recognition protein is required for insect reproduction and integument development

description: The myeloid differentiation factor 2 (MD-2)-related lipid-recognition protein is involved in immune responses through recognizing bacteria lipopolysaccharide in mammals, arthropods and plants. However, the physiological roles of MD-2 in other biological processes are largely unknown. Here, we identified three homologue MD-2 genes (<i>NlML1</i>, <i>NlML2</i> and <i>NlML3</i>) by searching the genome and transcriptome databases of the brown planthopper <i>Nilaparvata lugens</i>, a hemipteran insect species. Temporospatial analysis showed that the <i>NlML1</i> gene was highly expressed in the fat body but lowly expressed in the other tissues, while the <i>NlML2</i> and <i>NlML3</i> genes were highly expressed in the testis or digestive tract. RNA interference-mediated depletion of the <i>NlML1</i> gene significantly downregulated the transcription of numerous integument protein genes. The <i>NlML1</i> knockdown led to moulting failure and mortality at the nymph–adult transition phase, impaired egg laying and hatching and reduced 20-hydroxyecdysone (20E) production in the nymphs. 20E could rescue the deficient moulting phenotypes derived from ds<i>NlML1</i> RNAi. These novel findings indicate that <i>NlML1</i> is required for nymphal moulting and female reproductive success—as it plays an important role in regulating 20E synthesis, lipid and chitin metabolisms in <i>N. lugens</i>—thus contributing to our understanding of developmental and reproductive mechanisms in insects.
DOI: 10.6084/m9.figshare.17105163
title: NlML3.pdb from An MD-2-related lipid-recognition protein is required for insect reproduction and integument development

description: The myeloid differentiation factor 2 (MD-2)-related lipid-recognition protein is involved in immune responses through recognizing bacteria lipopolysaccharide in mammals, arthropods and plants. However, the physiological roles of MD-2 in other biological processes are largely unknown. Here, we identified three homologue MD-2 genes (<i>NlML1</i>, <i>NlML2</i> and <i>NlML3</i>) by searching the genome and transcriptome databases of the brown planthopper <i>Nilaparvata lugens</i>, a hemipteran insect species. Temporospatial analysis showed that the <i>NlML1</i> gene was highly expressed in the fat body but lowly expressed in the other tissues, while the <i>NlML2</i> and <i>NlML3</i> genes were highly expressed in the testis or digestive tract. RNA interference-mediated depletion of the <i>NlML1</i> gene significantly downregulated the transcription of numerous integument protein genes. The <i>NlML1</i> knockdown led to moulting failure and mortality at the nymph–adult transition phase, impaired egg laying and hatching and reduced 20-hydroxyecdysone (20E) production in the nymphs. 20E could rescue the deficient moulting phenotypes derived from ds<i>NlML1</i> RNAi. These novel findings indicate that <i>NlML1</i> is required for nymphal moulting and female reproductive success—as it plays an important role in regulating 20E synthesis, lipid and chitin metabolisms in <i>N. lugens</i>—thus contributing to our understanding of developmental and reproductive mechanisms in insects.
DOI: 10.6084/m9.figshare.17105163.v1
title: NlML3.pdb from An MD-2-related lipid-recognition protein is required for insect reproduction and integument development

description: The myeloid differentiation factor 2 (MD-2)-related lipid-recognition protein is involved in immune responses through recognizing bacteria lipopolysaccharide in mammals, arthropods and plants. However, the physiological roles of MD-2 in other biological processes are largely unknown. Here, we identified three homologue MD-2 genes (<i>NlML1</i>, <i>NlML2</i> and <i>NlML3</i>) by searching the genome and transcriptome databases of the brown planthopper <i>Nilaparvata lugens</i>, a hemipteran insect species. Temporospatial analysis showed that the <i>NlML1</i> gene was highly expressed in the fat body but lowly expressed in the other tissues, while the <i>NlML2</i> and <i>NlML3</i> genes were highly expressed in the testis or digestive tract. RNA interference-mediated depletion of the <i>NlML1</i> gene significantly downregulated the transcription of numerous integument protein genes. The <i>NlML1</i> knockdown led to moulting failure and mortality at the nymph–adult transition phase, impaired egg laying and hatching and reduced 20-hydroxyecdysone (20E) production in the nymphs. 20E could rescue the deficient moulting phenotypes derived from ds<i>NlML1</i> RNAi. These novel findings indicate that <i>NlML1</i> is required for nymphal moulting and female reproductive success—as it plays an important role in regulating 20E synthesis, lipid and chitin metabolisms in <i>N. lugens</i>—thus contributing to our understanding of developmental and reproductive mechanisms in insects.
DOI: 10.6084/m9.figshare.19726657
title: VGPs data in Tajikistan

description: This dataset provides VGPs data for the K2 section in Tajikistan.
DOI: 10.6084/m9.figshare.19726764
title: Additional file 1 of On prioritising global health’s triple crisis of sepsis, COVID-19 and antimicrobial resistance: a mixed-methods study from Malawi

description: Additional file 1.
DOI: 10.6084/m9.figshare.19726764.v1
title: Additional file 1 of On prioritising global health’s triple crisis of sepsis, COVID-19 and antimicrobial resistance: a mixed-methods study from Malawi

description: Additional file 1.
DOI: 10.6084/m9.figshare.10289597.v1
title: Structural basis of host ligand specificity change of GII porcine noroviruses from their closely related GII human noroviruses

description: Diverse noroviruses infect humans and animals via the recognition of host-specific glycan ligands. Genogroup II (GII) noroviruses consist of human noroviruses (huNoVs) that generally bind histo-blood group antigens (HBGAs) as host factors and three porcine norovirus (porNoV) genotypes (GII.11/18/19) that form a genetic lineage lacking HBGA-binding ability. Thus, these GII porNoVs provide an excellent model to study norovirus evolution with host ligand specificity changes. Here we solved the crystal structures of a native GII.11 porNoV P protein and a closely-related GII.3 huNoV P protein complexed with an HBGA, focusing on the HBGA-binding sites (HBSs) compared with the previously known ones to understand the structural basis of the host ligand specificity change. We found that the GII.3 huNoV binds HBGAs via a conventional GII HBS that uses an arginine instead of the conserved aromatic residue for the required Van der Waals interaction, while the GII.11 porNoV HBS loses its HBGA-binding function because of two mutations (Q355/V451). A mutant that reversed the two mutated residues back to the conventional A355/Y451 restored the HBGA-binding function of the GII.11 porNoV P protein, which validated our observations. Similar mutations are also found in GII.19 porNoVs and a GII.19 P protein mutant with double reverse mutations restored the HBS function. This is the first reconstruction of a functional HBS based on one with new host specificity back to its parental one. These data shed light on the molecular basis of structural adaptation of the GII porNoVs to the pig hosts through mutations at their HBSs.
DOI: 10.6084/m9.figshare.9765359
title: Name-Location

description: Geographically-explicit network of urban living and working in Shenzhen City, South China<br>
DOI: 10.6084/m9.figshare.9765368
title: Living-Working

description: Geographically-explicit network of urban living and working in Shenzhen City, South China
p.p1 {margin: 0.0px 0.0px 0.0px 0.0px; font: 12.0px 'Helvetica Neue'}
DOI: 10.6084/m9.figshare.9765377
title: STSGTool

description: STSGTool is a prototype system which has been implemented based on ArcObjects to streamline the analysis procedures of our new method. ArcObjects are a set of platform-independent software components designed by ESRI. The core algorithm and the graphical user interface of the prototype system were implemented with C#.NET. The land cover neighborhood graphs, land cover change trajectories, and node-wise connectivity changes can be visualized in both 2D or 3D environments.To Run the STSGTool, make sure you have installed the ArcGIS Desktop 10.1 , ArcEngine 10.1, and Microsoft Visual Studio 2010 on your computer.