cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.8059802.v1
title: Improving the motivation of students in a large introductory geoscience course through active learning

description: A collaboration between geoscience professors and pedagogic and technical support experts at Universidad de los Andes led to a teaching innovation, as part of a project entitled GEOC-SENSE. GEOC-SENSE was based on the use of active pedagogy techniques aided by information and communication technologies (ICT) to improve motivation and acquisition of transferable skills using active learning techniques and a flipped classroom structure. Lessons were divided into preclass, in-class, and postclass activities for students to acquire key concepts, to apply those concepts to solve in-class activities, and to reinforce acquired knowledge. The GEOC-SENSE project resolved major challenges previously identified in the geosciences course and, based on student surveys, improved student learning while allowing participants to develop transferable skills. This generated increased motivation in a diverse student population by making classes more dynamic and encouraging independent work. GEOC-SENSE allowed students to acquire knowledge using problem-solving skills, practical activities, and in general increased interaction in the classroom. The activities were perceived by students as directly applicable to a professional setting, making the course more relevant for students’ subsequent careers. The project increased student motivation and skill development; however, it also posed challenges: mainly difficulties when working in groups and accessing the ICT tools by some of the students.
DOI: 10.6084/m9.figshare.8059784
title: Dataset: Patterns of illicit drug use in PLHIV Spain.xls

description: This dataset is part of a study that assessed the prevalence and patterns of drug use among people living with HIV (PLHIV) in Spain. We conducted an observational cross-section study in which 1401 PLHIV participated. Data were collected through 33 sites across Spain using an online computer-assisted self-administered interview. The survey measured use of illicit drugs and other substances, treatment adherence and other health-related variables. This dataset contains 188 of these variables that were used for the analysis. It is on Excel format. The file contains three sheets:<br>Sheet . It contains the dataset. The first row of the table corresponds to variable names.<br>Sheet . It contains a description of each variable. Some of the variables correspond to items from the questionnaire. In those cases, the descriptions corresponds to the translation of the question asked to the participants. <br>Sheet . It contains the labels of the values in the dataset, for each categorical codified variable. Variables not listed in this sheet are numeric, meaning that the numbers on those variables are the real values of the variables, and not a code. <br><br><br>
DOI: 10.6084/m9.figshare.8059907.v1
title: The relation between brain signal complexity and task difficulty on an executive function task: data

description: The data that accompanies "The relation between brain signal complexity and task difficulty on an executive function task"
DOI: 10.6084/m9.figshare.8059907.v3
title: The relation between brain signal complexity and task difficulty on an executive function task: data

description: The data that accompanies "The relation between brain signal complexity and task difficulty on an executive function task"
DOI: 10.6084/m9.figshare.8059907.v2
title: The relation between brain signal complexity and task difficulty on an executive function task: data

description: The data that accompanies "The relation between brain signal complexity and task difficulty on an executive function task"
DOI: 10.5519/qd.4q0j4b3q
title: Query on the Natural History Museum Data Portal (data.nhm.ac.uk) (444 records)
DOI: 10.5517/ccdc.csd.cc24m1b5
title: CCDC 1984506: Experimental Crystal Structure Determination

description: Related Article: Donghong Lin, Min Luo, Chensheng Lin, Liling Cao, Ning Ye|2020|Cryst.Growth Des.|20|4904|doi:10.1021/acs.cgd.0c00837
DOI: 10.5517/ccdc.csd.cc24vpb1
title: CCDC 1991853: Experimental Crystal Structure Determination

description: Related Article: Chen‐Xi Ye, Shuming Chen, Feng Han, Xiulan Xie, Sergei Ivlev, K. N. Houk, Eric Meggers|2020|Angew.Chem.,Int.Ed.|59|13552|doi:10.1002/anie.202004799
DOI: 10.5517/ccdc.csd.cc24z2ks
title: CCDC 1995115: Experimental Crystal Structure Determination

description: Related Article: Masataka Ito, Hironori Suzuki, Shuji Noguchi|2020|Cryst.Growth Des.|20|4892|doi:10.1021/acs.cgd.0c00790
DOI: 10.5517/ccdc.csd.cc24z2lt
title: CCDC 1995116: Experimental Crystal Structure Determination

description: Related Article: Masataka Ito, Hironori Suzuki, Shuji Noguchi|2020|Cryst.Growth Des.|20|4892|doi:10.1021/acs.cgd.0c00790
DOI: 10.5517/ccdc.csd.cc24z2mv
title: CCDC 1995117: Experimental Crystal Structure Determination

description: Related Article: Masataka Ito, Hironori Suzuki, Shuji Noguchi|2020|Cryst.Growth Des.|20|4892|doi:10.1021/acs.cgd.0c00790
DOI: 10.5517/ccdc.csd.cc24z2nw
title: CCDC 1995118: Experimental Crystal Structure Determination

description: Related Article: Masataka Ito, Hironori Suzuki, Shuji Noguchi|2020|Cryst.Growth Des.|20|4892|doi:10.1021/acs.cgd.0c00790
DOI: 10.6084/m9.figshare.8059307
title: Supplementary Material for: Passive Monitoring at Home: A Pilot Study in Parkinson Disease

description: We conducted a pilot study using a passive radio-wave-based home monitor in individuals with Parkinson disease (PD) with a focus on gait, home activity, and time in bed. We enrolled 7 ambulatory individuals to have the device installed in the bedroom of their homes over 8 weeks and performed standard PD assessments at baseline. We evaluated the ability of the device to objectively measure gait and time in bed and to generate novel visualizations of home activity. We captured 353 days of monitoring. Mean gait speed (0.39–0.78 m/s), time in bed per day (4.4–12.1 h), and number (1.4–5.9) and duration (15.0–49.8 min) of nightly awakenings varied substantially across and within individuals. Derived gait speed correlated well with the Movement Disorder Society-Unified Parkinson’s Disease Rating Scale total (<i>r</i> = –0.88, <i>p</i> = 0.009) and motor sub-score (<i>r</i> = –0.95, <i>p</i> = 0.001). Six of the seven participants agreed that their activity was typical and indicated a willingness to continue monitoring. This technology provided promising new insights into the home activities of those with PD and may be broadly applicable to other chronic conditions.
DOI: 10.6084/m9.figshare.8059307.v1
title: Supplementary Material for: Passive Monitoring at Home: A Pilot Study in Parkinson Disease

description: We conducted a pilot study using a passive radio-wave-based home monitor in individuals with Parkinson disease (PD) with a focus on gait, home activity, and time in bed. We enrolled 7 ambulatory individuals to have the device installed in the bedroom of their homes over 8 weeks and performed standard PD assessments at baseline. We evaluated the ability of the device to objectively measure gait and time in bed and to generate novel visualizations of home activity. We captured 353 days of monitoring. Mean gait speed (0.39–0.78 m/s), time in bed per day (4.4–12.1 h), and number (1.4–5.9) and duration (15.0–49.8 min) of nightly awakenings varied substantially across and within individuals. Derived gait speed correlated well with the Movement Disorder Society-Unified Parkinson’s Disease Rating Scale total (<i>r</i> = –0.88, <i>p</i> = 0.009) and motor sub-score (<i>r</i> = –0.95, <i>p</i> = 0.001). Six of the seven participants agreed that their activity was typical and indicated a willingness to continue monitoring. This technology provided promising new insights into the home activities of those with PD and may be broadly applicable to other chronic conditions.
DOI: 10.5517/ccdc.csd.cc25svhb
title: CCDC 2019882: Experimental Crystal Structure Determination

description: Related Article: Li Qiao, Peng-Peng Cai, Zhong-Hua Shen, Hong-Ke Wu, Cheng-Xia Tan, Jian-Quan Weng, Xing-Hai Liu|2019|Heterocyclic Communications|25|66|doi:10.1515/hc-2019-0012
DOI: 10.5517/ccdc.csd.cc25sw40
title: CCDC 2019902: Experimental Crystal Structure Determination

description: Related Article: Antoine Blaise Kama, Erwann Jeanneau, Mamadou Sidibe, Cheikh A.K. Diop, Romain Gautier|2019|J.Cryst.Growth|528|125267|doi:10.1016/j.jcrysgro.2019.125267
DOI: 10.5517/ccdc.csd.cc25sw51
title: CCDC 2019903: Experimental Crystal Structure Determination

description: Related Article: Antoine Blaise Kama, Erwann Jeanneau, Mamadou Sidibe, Cheikh A.K. Diop, Romain Gautier|2019|J.Cryst.Growth|528|125267|doi:10.1016/j.jcrysgro.2019.125267
DOI: 10.5517/ccdc.csd.cc25sx85
title: CCDC 2019937: Experimental Crystal Structure Determination

description: Related Article: Marwa Abid Derbel, Mark M. Turnbull, Houcine Naïli, Walid Rekik|2020|Polyhedron|175|114220|doi:10.1016/j.poly.2019.114220
DOI: 10.6084/m9.figshare.8059208
title: data base

description: these is a data base for our study research
DOI: 10.6084/m9.figshare.8059208.v1
title: data base

description: these is a data base for our study research
DOI: 10.6084/m9.figshare.8059148
title: Characterization of 5-methylcytosine and 5-hydroxymethylcytosine in human placenta cell types across gestation

description: The placenta is an important organ in pregnancy, however, very little is understood about placental development at a molecular level. This includes the role of epigenetic mechanisms and how they change throughout gestation. DNA methylation studies in this organ are complicated by the different cell types that make up the placenta, each with their own unique transcriptome and epigenome. Placental dysfunction is often associated with pregnancy complications such as preeclampsia (PE). Aberrant DNA methylation in the placenta has been identified in pregnancy complications. We used immunohistochemistry (IHC) and immunofluorescence (IF) to localize 5-methylcytosine (5-mC) and 5-hydroxymethylcytosine (5-hmC) in placenta tissue from first and second trimester as well as uncomplicated term and PE samples. IHC analysis of whole placental tissues showed 5-mC increased across gestation. When cytotrophoblasts (CTB) and syncytiotrophoblasts (STB) were isolated and assessed using IF, both 5-mC and 5-hmC increased in term CTBs compared to first/second-trimester samples. Staining intensity of 5-hmC was higher in first/second trimester STBs compared to CTBs (P = 0.0011). Finally, IHC staining of term tissue from PE and uncomplicated pregnancies revealed higher 5-mC staining intensity in placentas from PE pregnancies (P = 0.028). Our study has shown increased 5-mC and 5-hmC staining intensities across gestation and differed between two trophoblast populations. Differences in DNA methylation profiles between placental cell types may be indicative of different functions and requires further study to elucidate what changes accompany placental pathologies.
DOI: 10.6084/m9.figshare.8059148.v2
title: Characterization of 5-methylcytosine and 5-hydroxymethylcytosine in human placenta cell types across gestation

description: The placenta is an important organ in pregnancy, however, very little is understood about placental development at a molecular level. This includes the role of epigenetic mechanisms and how they change throughout gestation. DNA methylation studies in this organ are complicated by the different cell types that make up the placenta, each with their own unique transcriptome and epigenome. Placental dysfunction is often associated with pregnancy complications such as preeclampsia (PE). Aberrant DNA methylation in the placenta has been identified in pregnancy complications. We used immunohistochemistry (IHC) and immunofluorescence (IF) to localize 5-methylcytosine (5-mC) and 5-hydroxymethylcytosine (5-hmC) in placenta tissue from first and second trimester as well as uncomplicated term and PE samples. IHC analysis of whole placental tissues showed 5-mC increased across gestation. When cytotrophoblasts (CTB) and syncytiotrophoblasts (STB) were isolated and assessed using IF, both 5-mC and 5-hmC increased in term CTBs compared to first/second-trimester samples. Staining intensity of 5-hmC was higher in first/second trimester STBs compared to CTBs (P = 0.0011). Finally, IHC staining of term tissue from PE and uncomplicated pregnancies revealed higher 5-mC staining intensity in placentas from PE pregnancies (P = 0.028). Our study has shown increased 5-mC and 5-hmC staining intensities across gestation and differed between two trophoblast populations. Differences in DNA methylation profiles between placental cell types may be indicative of different functions and requires further study to elucidate what changes accompany placental pathologies.
DOI: 10.6084/m9.figshare.8059148.v1
title: Characterization of 5-methylcytosine and 5-hydroxymethylcytosine in human placenta cell types across gestation

description: The placenta is an important organ in pregnancy, however, very little is understood about placental development at a molecular level. This includes the role of epigenetic mechanisms and how they change throughout gestation. DNA methylation studies in this organ are complicated by the different cell types that make up the placenta, each with their own unique transcriptome and epigenome. Placental dysfunction is often associated with pregnancy complications such as preeclampsia (PE). Aberrant DNA methylation in the placenta has been identified in pregnancy complications. We used immunohistochemistry (IHC) and immunofluorescence (IF) to localize 5-methylcytosine (5-mC) and 5-hydroxymethylcytosine (5-hmC) in placenta tissue from first and second trimester as well as uncomplicated term and PE samples. IHC analysis of whole placental tissues showed 5-mC increased across gestation. When cytotrophoblasts (CTB) and syncytiotrophoblasts (STB) were isolated and assessed using IF, both 5-mC and 5-hmC increased in term CTBs compared to first/second-trimester samples. Staining intensity of 5-hmC was higher in first/second trimester STBs compared to CTBs (P = 0.0011). Finally, IHC staining of term tissue from PE and uncomplicated pregnancies revealed higher 5-mC staining intensity in placentas from PE pregnancies (P = 0.028). Our study has shown increased 5-mC and 5-hmC staining intensities across gestation and differed between two trophoblast populations. Differences in DNA methylation profiles between placental cell types may be indicative of different functions and requires further study to elucidate what changes accompany placental pathologies.
DOI: 10.6084/m9.figshare.8059049
title: Supplementary Material for: Unusual Course of an Aggressive Pituitary Prolactinoma: Case Report and Review of the Literature

description: Pituitary carcinomas are rare tumors with heterogeneous behaviors. Their carcinogenesis is still unknown. Consequently, treatment is multimodal and not standardized. Dopamine (DA) agonists are used as first-line treatments, while radiotherapy and surgery may be used for local control of invasive tumors. We describe the case of a 35-year-old male who presented with an invasive prolactinoma, managed initially with a transsphenoidal resection, postsurgical radiotherapy and DA agonists. The patient posteriorly presented a sole metastatic lesion to the lumbar spine that was later managed with local radiotherapy. Due to pituitary recurrence of the lesion, multiple surgical resections were needed until further treatment was declined. The clinical course in this patient was unusual. He lived for 13 years after initial diagnosis, with a very invasive tumor without systemic chemotherapy. Radiotherapy is used in pituitary tumors in which surgery fails; we hypothesize that it contributed to the malignant transformation and the late resistance to DA agonists in our patient. Several biomarkers in tumoral tissue have been evaluated regarding their association with malignancy and aggressive behaviors, although more studies are still needed. Therapeutic strategies are limited, without evidence on the impact on overall survival and prognosis. Risk factors associated with early malignancy in pituitary prolactinomas include recurrent behavior, increase in prolactin levels with a stable sellar mass, and secondary development of DA agonist resistance. However, there are still no conclusive answers as to whether physicians should rigorously follow up these patients or provide direct therapy with aggressive approaches.
DOI: 10.6084/m9.figshare.8058977
title: My Report Title

description: Introduction<br>dfasdf<br><br>Methods<br>dfas<br><br>
DOI: 10.6084/m9.figshare.8058974
title: MIGRANT CARAVAN EXCEL FILE.pdf

description: Inductively derived code chart for research study about Instagram posts under the #MigrantCaravan or #CaravanaMigrante hashtags
DOI: 10.6084/m9.figshare.8059049.v1
title: Supplementary Material for: Unusual Course of an Aggressive Pituitary Prolactinoma: Case Report and Review of the Literature

description: Pituitary carcinomas are rare tumors with heterogeneous behaviors. Their carcinogenesis is still unknown. Consequently, treatment is multimodal and not standardized. Dopamine (DA) agonists are used as first-line treatments, while radiotherapy and surgery may be used for local control of invasive tumors. We describe the case of a 35-year-old male who presented with an invasive prolactinoma, managed initially with a transsphenoidal resection, postsurgical radiotherapy and DA agonists. The patient posteriorly presented a sole metastatic lesion to the lumbar spine that was later managed with local radiotherapy. Due to pituitary recurrence of the lesion, multiple surgical resections were needed until further treatment was declined. The clinical course in this patient was unusual. He lived for 13 years after initial diagnosis, with a very invasive tumor without systemic chemotherapy. Radiotherapy is used in pituitary tumors in which surgery fails; we hypothesize that it contributed to the malignant transformation and the late resistance to DA agonists in our patient. Several biomarkers in tumoral tissue have been evaluated regarding their association with malignancy and aggressive behaviors, although more studies are still needed. Therapeutic strategies are limited, without evidence on the impact on overall survival and prognosis. Risk factors associated with early malignancy in pituitary prolactinomas include recurrent behavior, increase in prolactin levels with a stable sellar mass, and secondary development of DA agonist resistance. However, there are still no conclusive answers as to whether physicians should rigorously follow up these patients or provide direct therapy with aggressive approaches.
DOI: 10.6084/m9.figshare.8058977.v1
title: My Report Title

description: Introduction<br>dfasdf<br><br>Methods<br>dfas<br><br>
DOI: 10.6084/m9.figshare.8058974.v1
title: MIGRANT CARAVAN EXCEL FILE.pdf

description: Inductively derived code chart for research study about Instagram posts under the #MigrantCaravan or #CaravanaMigrante hashtags
DOI: 10.6084/m9.figshare.8058926
title: Supplementary Material for: Brain Connectivity in <b><i>Ateles geoffroyi</i></b>: Resting-State Functional Magnetic Resonance Imaging of Working Memory and Executive Control

description: The objective of this research was to describe the organization and connectivity of the working memory (WM) and executive control (EC) networks in <i>Ateles geoffroyi</i> in resting-state conditions. Recent studies have shown that resting-state activity may underlie rudimentary brain functioning, showing that several brain regions can be tonically active at rest, maximizing the efficiency of information transfer while preserving a low physical connection cost. Whole-brain resting-state images were acquired from three healthy adult <i>Ateles</i> monkeys (2 females, 1 male; mean age 10.5 ± SD 2.5 years). Data were analyzed with independent component analysis, and results were grouped together using the GIFT software. The present study compared the EC and WM networks obtained with human data and with results found in the literature in other primate species. Nine resting-state networks were found, which were similar to resting networks found in healthy human adults in the prefrontal basal portion and frontopolar area. Additionally, components of the WM network were found to be extending into the hypothalamus and the olfactory areas. A key finding was the discovery of connections in the WM and EC networks to the hypothalamus, the motor cortex, and the entorhinal cortex, suggesting that information is integrated from larger brain areas. The correlated areas suggest that many elements of WM and EC may be conserved across primate species. Characterization of these networks in resting-state conditions in nonhuman primate brains is a fundamental prerequisite for understanding of the neural bases underlying the evolution and function of this cognitive system.
DOI: 10.6084/m9.figshare.8058854
title: Dataset 2.2: Human amino-acids raw data

description: Supplementary Dataset from the work "Rules of amino acid composition by which disordered regions adjust to high expression".<br>This table contains amino-acid level information of human proteins.<br><br>
DOI: 10.6084/m9.figshare.8058887
title: Measuring the structural impact of mutations on cytochrome P450 21A2, the major steroid 21-hydroxylase related to congenital adrenal hyperplasia

description: Congenital adrenal hyperplasia is an inherited autosomal recessive disorder related to deficient cortisol synthesis. The deficiency of steroid 21-hydroxylase (cytochrome P450 21A2), an enzyme involved in cortisol synthesis, is responsible for ∼95% of cases of congenital adrenal hyperplasia. This metabolic disease exhibits three clinical forms: salt-wasting, simple virilizing, and non-classical form, which are divided according to the degree of severity. In the present study, structural and mutational analyses were performed in order to identify the structural impact of mutations on cytochrome P450 21A2 and correlate them with patient clinical severity. The following mutations were selected: arginine-356 to tryptophan (R356W), proline-30 to leucine (P30L), isoleucine-172 to asparagine (I172N), valine-281 to leucine (V281L), and the null mutation glutamine-318 (Q318X). Our computational approach mapped the location of residues on P450 and identified their implications on enzyme electrostatic potential mapping to progesterone and heme binding pockets. Using molecular dynamics simulations, we analyzed the structural stability of ligand binding and protein structure, as well as possible conformational changes at the catalytic pocket that leads to impairment of enzymatic activity. Our study sheds light on the impact structural mutations have over steroid 21-hydroxylase structure-function in the cell. Communicated by Ramaswamy H. Sarma