cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.21161922.v1
title: Energy and lipid contents, and polyphenols composition of pequi pulp according to the fruit native area

description: ABSTRACT: Pequi (Caryocar spp.) is a fruit native to the Brazilian Savannah (Cerrado), and Caryocar brasilienseCamb. is one of the most prevalent species in this biome. The consumption of the pequi pulp has been associated with health benefits, such as antioxidant, anti-inflammatory, hypolipidemic, hepatoprotective, and anticarcinogenic effects. These benefits have been attributed to its high density in nutrients and bioactive compounds. However, there is evidence about considerable variation in the nutritional profile among pequi pulps of different species, and among pulps of the same species, but from different areas of the Cerrado. In addition, there is no information in literature regarding the polyphenols profile of C. brasiliense pulp, neither about the influence of the native area of the fruit on the composition of these phytochemicals. So, this study analyzed the nutrient composition and identified the phenolic compounds in the pulp of C. brasiliense fruits native to four different areas of the Cerrado. There was a remarkable variation in the contents of energy (176.3-387.2 kcal/100 g) and lipids (13.0-37.5 g/100 g) among samples. In contrast, no difference was observed in the polyphenols composition, since gallic acid, protocatechuic acid, catechin, epicatechin, p-coumaric acid, and ellagic acid were identified in all pequi pulps. C. brasiliense pulp shows potential to be used as a functional ingredient rich in bioactive compounds, but with different contents of energy and lipids according to the fruit’s native area to attempt distinct health allegations of the product.
DOI: 10.6084/m9.figshare.21161923
title: Implications of lysyl oxidase-like protein 3 expression in the periodontium of diabetic rats

description: Abstract Objectives Diabetes has been strongly associated with periodontal diseases. The periodontal ligament (PDL) has an abundant extracellular matrix (ECM). Lysyl oxidases (LOXs) are closely associated with various diseases caused by abnormal ECM functions, however, the role of LOXs in periodontal diseases induced by diabetes remains unclear. Methodology In this study, 8-week-old Zucker diabetic fatty rats were used to establish a type 2 diabetes mellitus (T2DM) model. After 9 and 16 weeks, hematoxylin and eosin (H&E), Masson’s trichrome, and immunohistochemical staining were performed. Results After 9 weeks, loose collagen fibers were found in the interradicular area of the diabetic group, in opposition to the control group. There were no significant differences in LOX expression between the diabetic and control groups (p&gt;0.05). However, after 16 weeks, the diabetic group presented a disordered arrangement of the PDL, showing decreased collagen content and significantly increased lysyl oxidase-like protein 3 (LOXL3) expression when compared with the control group (p&lt;0.05). This suggests that LOXL3 plays a significant role in periodontal histopathological changes in diabetic rats. Conclusion Our study showed elevated LOXL3 expression in the PDL of diabetic rats after 16 weeks, suggesting that LOXL3 may be involved in the occurrence and development of periodontal histopathological changes in diabetic rats. LOXL3 could be further used as an indicator for the early diagnosis of diabetic periodontitis in T2DM patients in clinical settings.
DOI: 10.6084/m9.figshare.21161923.v1
title: Implications of lysyl oxidase-like protein 3 expression in the periodontium of diabetic rats

description: Abstract Objectives Diabetes has been strongly associated with periodontal diseases. The periodontal ligament (PDL) has an abundant extracellular matrix (ECM). Lysyl oxidases (LOXs) are closely associated with various diseases caused by abnormal ECM functions, however, the role of LOXs in periodontal diseases induced by diabetes remains unclear. Methodology In this study, 8-week-old Zucker diabetic fatty rats were used to establish a type 2 diabetes mellitus (T2DM) model. After 9 and 16 weeks, hematoxylin and eosin (H&E), Masson’s trichrome, and immunohistochemical staining were performed. Results After 9 weeks, loose collagen fibers were found in the interradicular area of the diabetic group, in opposition to the control group. There were no significant differences in LOX expression between the diabetic and control groups (p&gt;0.05). However, after 16 weeks, the diabetic group presented a disordered arrangement of the PDL, showing decreased collagen content and significantly increased lysyl oxidase-like protein 3 (LOXL3) expression when compared with the control group (p&lt;0.05). This suggests that LOXL3 plays a significant role in periodontal histopathological changes in diabetic rats. Conclusion Our study showed elevated LOXL3 expression in the PDL of diabetic rats after 16 weeks, suggesting that LOXL3 may be involved in the occurrence and development of periodontal histopathological changes in diabetic rats. LOXL3 could be further used as an indicator for the early diagnosis of diabetic periodontitis in T2DM patients in clinical settings.
DOI: 10.6084/m9.figshare.21161928
title: Negative Events, Coping and Biological Markers: An Application of Transactional Model of Stress,

description: Abstract Based on the importance of the stress phenomenon, this research sought to evaluate the relationship between stress, coping strategies, negative life events and biological markers, based on the Transactional Stress Model. A general hypothesis of mediation was formulated: coping strategies would mediate the relationship between negative life events and biological markers. The sample consisted of 96 users of a biomedical school laboratory, in which 77.78% were female. Participants answered the Brief COPE questionnaire, as well as a questionnaire on negative life events. Laboratory tests were collected shortly after the application of the questionnaires. Mediations were found between Venting, Red Blood Cells and Hemoglobin. The research aimed to contribute to the knowledge in the field of stress and coping, as well as to serve as a possible empirical study of the Transactional Stress model.
DOI: 10.6084/m9.figshare.21161928.v1
title: Negative Events, Coping and Biological Markers: An Application of Transactional Model of Stress,

description: Abstract Based on the importance of the stress phenomenon, this research sought to evaluate the relationship between stress, coping strategies, negative life events and biological markers, based on the Transactional Stress Model. A general hypothesis of mediation was formulated: coping strategies would mediate the relationship between negative life events and biological markers. The sample consisted of 96 users of a biomedical school laboratory, in which 77.78% were female. Participants answered the Brief COPE questionnaire, as well as a questionnaire on negative life events. Laboratory tests were collected shortly after the application of the questionnaires. Mediations were found between Venting, Red Blood Cells and Hemoglobin. The research aimed to contribute to the knowledge in the field of stress and coping, as well as to serve as a possible empirical study of the Transactional Stress model.
DOI: 10.6084/m9.figshare.21161931
title: Surgical capacity assessment in the state of Amazonas using the surgical assessment tool. Cross-sectional study

description: ABSTRACT Objective: Brazil is a country with universal health coverage, yet access to surgery among remote rural populations remains understudied. This study assesses surgical care capacity among hospitals providing care for the rural populations in the Amazonas state of Brazil through in-depth facility assessments. Methods: a stratified randomized cross-sectional evaluation of hospitals that self-report providing surgical care in Amazonas was conducted from July 2016 to March 2017. The Surgical Assessment Tool (SAT) developed by the World Health Organization and the Program in Global Surgery and Social Change at Harvard Medical School was administered at remote hospitals, including a retrospective review of medical records and operative logbooks. Results: 18 hospitals were surveyed. Three hospitals (16.6%) had no operating rooms and 12 (66%) had 1-2 operating rooms. 14 hospitals (77.8%) reported monitoring by pulse oximetry was always present and six hospitals (33%) never have a professional anesthesiologist available. Inhaled general anesthesia was available in 12 hospitals (66.7%), but 77.8% did not have any mechanical ventilation device. An average of 257 procedures per 100,000 were performed. 10 hospitals (55.6%) do not have a specific post-anesthesia care unit. For the regions covered by the 18 hospitals, with a population of 497,492 inhabitants, the average surgeon, anesthetist, obstetric workforce density was 6.4. Conclusion: populations living in rural areas in Brazil face significant disparities in access to surgical care, despite the presence of universal health coverage. Development of a state plan for the implementation of surgery is necessary to ensure access to surgical care for rural populations.
DOI: 10.6084/m9.figshare.21161931.v1
title: Surgical capacity assessment in the state of Amazonas using the surgical assessment tool. Cross-sectional study

description: ABSTRACT Objective: Brazil is a country with universal health coverage, yet access to surgery among remote rural populations remains understudied. This study assesses surgical care capacity among hospitals providing care for the rural populations in the Amazonas state of Brazil through in-depth facility assessments. Methods: a stratified randomized cross-sectional evaluation of hospitals that self-report providing surgical care in Amazonas was conducted from July 2016 to March 2017. The Surgical Assessment Tool (SAT) developed by the World Health Organization and the Program in Global Surgery and Social Change at Harvard Medical School was administered at remote hospitals, including a retrospective review of medical records and operative logbooks. Results: 18 hospitals were surveyed. Three hospitals (16.6%) had no operating rooms and 12 (66%) had 1-2 operating rooms. 14 hospitals (77.8%) reported monitoring by pulse oximetry was always present and six hospitals (33%) never have a professional anesthesiologist available. Inhaled general anesthesia was available in 12 hospitals (66.7%), but 77.8% did not have any mechanical ventilation device. An average of 257 procedures per 100,000 were performed. 10 hospitals (55.6%) do not have a specific post-anesthesia care unit. For the regions covered by the 18 hospitals, with a population of 497,492 inhabitants, the average surgeon, anesthetist, obstetric workforce density was 6.4. Conclusion: populations living in rural areas in Brazil face significant disparities in access to surgical care, despite the presence of universal health coverage. Development of a state plan for the implementation of surgery is necessary to ensure access to surgical care for rural populations.
DOI: 10.6084/m9.figshare.21161932
title: Collector mixtures and their synergistic effect on quartz floatability

description: Abstract Sinergy is the interaction of two or more agents to produce a combined effect greater than the sum of their separate effects. Etherdiamine yields superior results for quartz floatability in a Hallimond tube and higher selectivity in the reverse bench scale cationic flotation of an iron ore, when compared to ethermonoamine. Blending these collectors yields better results than each one used individually characterizing a synergistic effect. This work evaluated the effects of the collectors ethermonoamine, etherdiamine and the mixture of these at the ratio 1:1 on the flotation of the quartz through the microflotation and bench flotation tests with a typical Brazilian iron ore. The results demonstrated the occurrence of synergistic effects in tests performed at concentrations of 1 and 3 mg/L and pH 10.5, in the absence of a depressant. In the presence of a depressant, the synergy was not observed under the same tested conditions, due to the collector-depressant interaction. On other hand, the bench flotation tests indicated the occurrence of synergy regarding silica content in the concentrate while an additive effect was observed for the iron recovery and Selectivity Index index demonstrating that a feasibility of using collector mixtures in this process, was not clearly achieved on the tested ratio 1:1.
DOI: 10.6084/m9.figshare.21161932.v1
title: Collector mixtures and their synergistic effect on quartz floatability

description: Abstract Sinergy is the interaction of two or more agents to produce a combined effect greater than the sum of their separate effects. Etherdiamine yields superior results for quartz floatability in a Hallimond tube and higher selectivity in the reverse bench scale cationic flotation of an iron ore, when compared to ethermonoamine. Blending these collectors yields better results than each one used individually characterizing a synergistic effect. This work evaluated the effects of the collectors ethermonoamine, etherdiamine and the mixture of these at the ratio 1:1 on the flotation of the quartz through the microflotation and bench flotation tests with a typical Brazilian iron ore. The results demonstrated the occurrence of synergistic effects in tests performed at concentrations of 1 and 3 mg/L and pH 10.5, in the absence of a depressant. In the presence of a depressant, the synergy was not observed under the same tested conditions, due to the collector-depressant interaction. On other hand, the bench flotation tests indicated the occurrence of synergy regarding silica content in the concentrate while an additive effect was observed for the iron recovery and Selectivity Index index demonstrating that a feasibility of using collector mixtures in this process, was not clearly achieved on the tested ratio 1:1.
DOI: 10.6084/m9.figshare.21161934.v1
title: Neurobehavioral signals in preterm infants in body weight check: a quasi-experimental study

description: ABSTRACT Objective: to describe and compare the frequency of neurobehavioral signs in preterm infants in traditional and humanized body weight check. Methods: a quantitative, quasi-experimental, cross-over study, carried out in a Neonatal Unit at a university hospital with a sample of 30 preterm newborns, randomly assigned and allocated in control group (traditional) and intervention group (humanized), with collection of general data, vital signs before and after procedures and footage. Results: there was a higher frequency of approach signs in humanized weight check compared to traditional check. Moreover, withdrawal signs were more frequent in traditional weight check compared to humanized check. Conclusion: in this regard, humanized body weight check provided greater benefits to preterm infants, making it necessary to foster discussions about humanization of care, so that this practice can be performed routinely in health units.
DOI: 10.6084/m9.figshare.21161934
title: Neurobehavioral signals in preterm infants in body weight check: a quasi-experimental study

description: ABSTRACT Objective: to describe and compare the frequency of neurobehavioral signs in preterm infants in traditional and humanized body weight check. Methods: a quantitative, quasi-experimental, cross-over study, carried out in a Neonatal Unit at a university hospital with a sample of 30 preterm newborns, randomly assigned and allocated in control group (traditional) and intervention group (humanized), with collection of general data, vital signs before and after procedures and footage. Results: there was a higher frequency of approach signs in humanized weight check compared to traditional check. Moreover, withdrawal signs were more frequent in traditional weight check compared to humanized check. Conclusion: in this regard, humanized body weight check provided greater benefits to preterm infants, making it necessary to foster discussions about humanization of care, so that this practice can be performed routinely in health units.
DOI: 10.6084/m9.figshare.21161944
title: When to think about a Lachesis muta envenomation in the Western Brazilian Amazon: Lessons from a case report

description: ABSTRACT In the Brazilian Amazon, envenomations by lancehead pit vipers prevail across the region, while bushmaster (Lachesis muta) envenomations are rarely confirmed. Here, we described a moderate snakebite, diagnosed as a lancehead pit viper envenomation upon admission and treated with four vials of Bothrops antivenom. Blood remained unclottable for 4 days of hospitalization. On day 4, after admission, the patient presented pictures of the perpetrating snake to the hospital staff, which was identified as a Lachesis muta specimen. After administering 10 vials of Lachesis antivenom, blood became clottable 12 hours after treatment. The patient was discharged without complaints.
DOI: 10.6084/m9.figshare.21161944.v1
title: When to think about a Lachesis muta envenomation in the Western Brazilian Amazon: Lessons from a case report

description: ABSTRACT In the Brazilian Amazon, envenomations by lancehead pit vipers prevail across the region, while bushmaster (Lachesis muta) envenomations are rarely confirmed. Here, we described a moderate snakebite, diagnosed as a lancehead pit viper envenomation upon admission and treated with four vials of Bothrops antivenom. Blood remained unclottable for 4 days of hospitalization. On day 4, after admission, the patient presented pictures of the perpetrating snake to the hospital staff, which was identified as a Lachesis muta specimen. After administering 10 vials of Lachesis antivenom, blood became clottable 12 hours after treatment. The patient was discharged without complaints.
DOI: 10.6084/m9.figshare.21161946
title: Effect of taxifolin on methotrexate-induced oxidative and inflammatory oral mucositis in rats: biochemical and histopathological evaluation

description: Abstract The role of oxidative stress, as well as inflammation in the pathogenesis of methotrexate (MTX)-induced oral mucositis, is a known fact. The anti-inflammatory, antitumor, antimicrobial, and antioxidant properties of taxifolin—the effect we tested against MTX-induced oral mucosal damage—are well known. Objective Evaluating biochemically and histopathologically the effects of taxifolin on methotrexate-induced oral mucosal damage in rats. Methodology In the taxifolin+MTX (TMTX) group, 50 mg/kg taxifolin was orally administered to rats by gavage. In the MTX and healthy (HG) groups, normal saline was applied to rats as solvent by the same method. One hour after administration of taxifolin and solvent, 5 mg/kg MTX was orally administered to rats in the MTX and TMTX groups. Taxifolin and methotrexate were administered once a day for 30 days. Macroscopic, biochemical, and histopathological evaluations were performed on the inner cheek and tongue tissues of rats. These parts were removed after rats were killed with a high-dose anesthesia. Results Taxifolin with MTX prevented the increase in oxidant and pro-inflammatory parameters, such as malondialdehyde (MDA), tumor necrosis factor alpha (TNF-α), interleukin 1 beta (IL-1β), interleukin 6 (IL-6), on the inner cheek and tongue tissues of rats. Moreover, taxifolin antagonized the decrease in total glutathione (tGSH). Taxifolin decreased MTX-induced histopathological damage. Conclusion These findings suggest that taxifolin may be useful to treat MTX-associated oral mucositis.
DOI: 10.6084/m9.figshare.21161946.v1
title: Effect of taxifolin on methotrexate-induced oxidative and inflammatory oral mucositis in rats: biochemical and histopathological evaluation

description: Abstract The role of oxidative stress, as well as inflammation in the pathogenesis of methotrexate (MTX)-induced oral mucositis, is a known fact. The anti-inflammatory, antitumor, antimicrobial, and antioxidant properties of taxifolin—the effect we tested against MTX-induced oral mucosal damage—are well known. Objective Evaluating biochemically and histopathologically the effects of taxifolin on methotrexate-induced oral mucosal damage in rats. Methodology In the taxifolin+MTX (TMTX) group, 50 mg/kg taxifolin was orally administered to rats by gavage. In the MTX and healthy (HG) groups, normal saline was applied to rats as solvent by the same method. One hour after administration of taxifolin and solvent, 5 mg/kg MTX was orally administered to rats in the MTX and TMTX groups. Taxifolin and methotrexate were administered once a day for 30 days. Macroscopic, biochemical, and histopathological evaluations were performed on the inner cheek and tongue tissues of rats. These parts were removed after rats were killed with a high-dose anesthesia. Results Taxifolin with MTX prevented the increase in oxidant and pro-inflammatory parameters, such as malondialdehyde (MDA), tumor necrosis factor alpha (TNF-α), interleukin 1 beta (IL-1β), interleukin 6 (IL-6), on the inner cheek and tongue tissues of rats. Moreover, taxifolin antagonized the decrease in total glutathione (tGSH). Taxifolin decreased MTX-induced histopathological damage. Conclusion These findings suggest that taxifolin may be useful to treat MTX-associated oral mucositis.
DOI: 10.6084/m9.figshare.21161952
title: Effect of prehydration of Portland cement on the superplasticizer consumption and the impact on the rheological properties and chemical reaction

description: Abstract The use of pre-hydrated cement in formulation of mortar and concrete is common because there is not always effective control on the cement production, grinding, transportation and subsequent storage. This paper presents a case study on the optimization of admixture for use with prehydrated cement by assessing changes in the rheological properties of Portland cement artificially pre-hydrated. The cement was artificially pre-hydrated by exposure to relative humidity (RHs) of 90%, in an environment of NH4Cl saturated solution. Additionally, the cement pastes were evaluated with and without superplasticizer. Stepped flow test using a parallel-plate geometry was the method choose to evaluate the rheological behavior, apparent viscosity, yield stress and hysteresis area of each paste at the early age. Oscillatory rheometry was conducted to evaluate the storage modulus (G’), comparing the consolidation with the hydration kinetics obtained by calorimetric evaluation of the same suspensions. Initial rheometer results indicate that the pre-hydrated sample presents lower level of shear stress than the reference sample, because of the higher reactivity of the non-pre-hydrated sample.
DOI: 10.6084/m9.figshare.21161952.v1
title: Effect of prehydration of Portland cement on the superplasticizer consumption and the impact on the rheological properties and chemical reaction

description: Abstract The use of pre-hydrated cement in formulation of mortar and concrete is common because there is not always effective control on the cement production, grinding, transportation and subsequent storage. This paper presents a case study on the optimization of admixture for use with prehydrated cement by assessing changes in the rheological properties of Portland cement artificially pre-hydrated. The cement was artificially pre-hydrated by exposure to relative humidity (RHs) of 90%, in an environment of NH4Cl saturated solution. Additionally, the cement pastes were evaluated with and without superplasticizer. Stepped flow test using a parallel-plate geometry was the method choose to evaluate the rheological behavior, apparent viscosity, yield stress and hysteresis area of each paste at the early age. Oscillatory rheometry was conducted to evaluate the storage modulus (G’), comparing the consolidation with the hydration kinetics obtained by calorimetric evaluation of the same suspensions. Initial rheometer results indicate that the pre-hydrated sample presents lower level of shear stress than the reference sample, because of the higher reactivity of the non-pre-hydrated sample.