cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.34894/qwar8p
title: Impact of treatment history on drug resistance of metastatic colorectal cancer organoids

description: Background
Treatment of metastatic colorectal cancer (mCRC) is impeded by the development of drug resistance. To increase treatment efficacy, we need to understand how exposure to earlier chemotherapy changes tumor cell genotype, phenotype, and resistance mechanisms. 
Methods 
We selected 35 patient-derived metastatic lesion organoids (PDOs) from 18 pretreated and 17 chemonaive mCRC patients. We investigated transcriptomic and genomic changes related to acquired drug resistance, by combining drug sensitivity assessments with RNA and whole genome sequencing. 
Results
PDOs from pretreated patients exhibited significantly higher tumor mutational load, more structural variants, and more deep deletions in driver genes at common fragile sites. Chemotherapy-related mutational signatures SBS17A, SBS17B and DBS5 were observed in PDOs from pretreated patients and the magnitude of these signatures correlated with previous exposure to 5-FU and oxaliplatin. PDOs derived from oxaliplatin-resistant patients captured the acquired resistance and did not show specific genomic alterations, but upregulation of resistance-associated genes ZNF300 and TGM2, along with enrichment of genes in the Hedgehog signaling pathway. In contrast, acquired resistance to 5-FU and irinotecan was only captured partially in PDOs. Acquired intrinsic resistance to irinotecan in pretreated PDOs correlated with specific genomic alterations: SBS17A and deep deletions in genes located at common fragile sites. These deletions were associated with a distinct gene expression profile with enrichment of BIRC3 and FBXO44. We identified 103 genes whose expression levels correlated with chemotherapy resistance in PDO drug screens. While oxaliplatin resistance correlated with gene expression in both primary and acquired resistant PDOs, correlations for SN-38 and 5-FU resistance were only observed in acquired resistant PDOs.
Conclusion
PDOs capture how chemotherapy induces accumulation of genomic mutations and phenotypic changes, which are related to exposure level and resistance. Acquired oxaliplatin resistance is maintained in PDOs through static tumor cell-intrinsic properties. In contrast, acquired resistance to irinotecan and 5-FU are only partially captured in PDOs, suggesting a larger role for dynamic, transient cell states or tumor cell extrinsic factors. This study sheds light on the tumor biology of heavily pretreated patients and the value of pretreated models in unraveling resistance mechanisms
DOI: 10.15468/dl.k9h27s
title: Occurrence Download

description: A dataset containing 2425 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Geometry POLYGON((23.34949 40.79707,23.47292 40.79707,23.47292 40.8573,23.34949 40.8573,23.34949 40.79707))",
 "HasCoordinate is true",
 "OccurrenceStatus is Present"
 ]
}

 The dataset includes 2425 records from 10 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0039237-250920141307145/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.me7gbn
title: Occurrence Download

description: A dataset containing 34431 species occurrences available in GBIF matching the query:
{
 "and" : [
 "BasisOfRecord is Human Observation",
 "Geometry POLYGON((25.35391 52.14573,7.08138 50.57169,6.26014 44.13867,24.12206 38.18469,25.62766 39.41655,34.79815 45.50739,25.35391 52.14573))",
 "OccurrenceStatus is Present",
 "TaxonKey is Anser albifrons"
 ]
}

 The dataset includes 34431 records from 68 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0039238-250920141307145/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.8q78jh
title: Occurrence Download

description: A dataset containing 8 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Apogonichthyoides pharaonis",
 "Country is Türkiye",
 "HasCoordinate is true"
 ]
}

 The dataset includes 8 records from 3 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0039239-250920141307145/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.37hs9p
title: Occurrence Download

description: A dataset containing 592 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is China",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 "TaxonKey is Sorghum halepense",
 "Year 1000-2025"
 ]
}

 The dataset includes 592 records from 6 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0039240-250920141307145/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.hxmaaz
title: Occurrence Download

description: A dataset containing 177637 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Araneae, Pseudoscorpiones, Trombidiformes, Archaeognatha, Blattodea, Coleoptera, Dermaptera, Diptera, Embioptera, Ephemeroptera, Grylloblattodea, Hemiptera, Hymenoptera, Lepidoptera, Mantodea, Mecoptera, Plecoptera, Neuroptera, Odonata, Orthoptera, Plecoptera, Psocodea, Siphonaptera, Strepsiptera, Thysanoptera, Trichoptera, Zygentoma, Uropygi, Megaloptera, Raphidioptera, Opiliones, Sarcoptiformes, Scorpiones, Schizomida, Amblypygi, Solifugae, Ricinulei, Palpigradi, Mantophasmatodea, Zoraptera)",
 "HasCoordinate is true",
 "Country is Japan",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 {
 "not" : {
 "BasisOfRecord" : [
 "is Fossil"
 ]
 }
 },
 "Year is greater than or equal to 1970",
 "CoordinateUncertaintyInMeters is less than 3000"
 ]
}

 The dataset includes 177637 records from 59 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0039223-250920141307145/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.qckzjz
title: Occurrence Download

description: A dataset containing 707995 species occurrences available in GBIF matching the query:
{
 "and" : [
 "BasisOfRecord is Human Observation",
 "Continent is one of (Africa, Europe, Asia)",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 "TaxonKey is Hirundo rustica",
 "Year 2024-2024"
 ]
}

 The dataset includes 707995 records from 88 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0039201-250920141307145/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.jdbukk
title: Occurrence Download

description: A dataset containing 103712 species occurrences available in GBIF matching the query:
{
 "and" : [
 "BasisOfRecord is one of (Observation, Human Observation, Specimen)",
 "Continent is Europe",
 "TaxonKey is Dianthus deltoides",
 "Year 1950-2025"
 ]
}

 The dataset includes 103712 records from 554 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0039197-250920141307145/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.hv5gsn
title: Occurrence Download

description: A dataset containing 10 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Cheilodipterus novemstriatus",
 "Country is Israel",
 "HasCoordinate is true"
 ]
}

 The dataset includes 10 records from 5 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0039242-250920141307145/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.j3r42n
title: Occurrence Download

description: A dataset containing 2 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Cheilodipterus novemstriatus",
 "Country is Cyprus",
 "HasCoordinate is true"
 ]
}

 The dataset includes 2 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0039241-250920141307145/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.6wksxq
title: Occurrence Download

description: A dataset containing 687893 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Populus tremula)",
 "HasCoordinate is true"
 ]
}

 The dataset includes 687893 records from 2525 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0039208-250920141307145/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.g389sr
title: Occurrence Download

description: A dataset containing 19 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Turbonilla fasciata (d'Orbigny, 1840)"
 ]
}

 The dataset includes 19 records from 4 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0102526-220831081235567/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.25549/pcra-c14-227240
title: The Word of Truth, 2002, vol. 13, no. 4-5 = Cuvantul Adevarului, 2002, anul XIII, nr 4-5

description: [description english/roman)] The Word of Truth is the periodical, official publication of the Romanian Pentecostal Church beginning from 1990 to present.
DOI: 10.15468/dl.qvexqp
title: Occurrence Download

description: A dataset containing 5 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Trachylepis nganghae Ineich & Chirio, 2004)",
 "BasisOfRecord is one of (Specimen, Human Observation, Observation, Machine Observation)",
 "HasCoordinate is true",
 "HasGeospatialIssue is false"
 ]
}

 The dataset includes 5 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0032500-230224095556074/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.25549/pcra-c14-227230
title: The Word of Truth, 2002, vol. 13, no. 4-5 = Cuvantul Adevarului, 2002, anul XIII, nr 4-5

description: [description english/roman)] The Word of Truth is the periodical, official publication of the Romanian Pentecostal Church beginning from 1990 to present.
DOI: 10.15468/dl.35jesh
title: Occurrence Download

description: A dataset containing 3 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Angraecum litorale Schltr."
 ]
}

 The dataset includes 3 records from 3 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0032568-230224095556074/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.eyhxwm
title: Occurrence Download

description: A dataset containing 260 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Geometry POLYGON((-98.20144 -19.76346,-16.79856 -19.76346,-16.79856 12.76346,-98.20144 12.76346,-98.20144 -19.76346))",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 "TaxonKey is Parkia discolor Spruce ex Benth."
 ]
}

 The dataset includes 260 records from 38 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0102485-220831081235567/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.4345yf
title: Occurrence Download

description: A dataset containing 8 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Angraecum liliodorum Frapp. ex Cordem."
 ]
}

 The dataset includes 8 records from 3 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0032543-230224095556074/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.j9sdk7
title: Occurrence Download

description: A dataset containing 233 species occurrences available in GBIF matching the query:
{
 "and" : [
 "OccurrenceStatus is Present",
 "TaxonKey is Oenothera drummondii subsp. drummondii"
 ]
}

 The dataset includes 233 records from 22 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0110184-220831081235567/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.g8nb6d
title: Occurrence Download

description: A dataset containing 24 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Hemidactylus agrius Vanzolini, 1978, Hemidactylus auritus Poeppig)",
 "BasisOfRecord is one of (Specimen, Human Observation, Observation, Machine Observation)",
 "HasCoordinate is true",
 "HasGeospatialIssue is false"
 ]
}

 The dataset includes 24 records from 3 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0032570-230224095556074/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.u53k5t
title: Occurrence Download

description: A dataset containing 3428 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Sphrageidus similis Füssly, 1775",
 "HasCoordinate is true",
 "HasGeospatialIssue is false"
 ]
}

 The dataset includes 3428 records from 29 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0128846-220831081235567/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.nfsxkz
title: Occurrence Download

description: A dataset containing 12 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Angraecum longicaule H.Perrier"
 ]
}

 The dataset includes 12 records from 5 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0032584-230224095556074/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.gwpb2f
title: Occurrence Download

description: A dataset containing 161 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Turbonilla hemphilli K.J.Bush"
 ]
}

 The dataset includes 161 records from 18 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0102554-220831081235567/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.apqg66
title: Occurrence Download

description: A dataset containing 71 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Sargassum flavifolium Kützing, 1849"
 ]
}

 The dataset includes 71 records from 10 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0110177-220831081235567/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.tvpfmf
title: Occurrence Download

description: A dataset containing 2 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Anolis pseudokemptoni Köhler, Ponce, Sunyer & Batista, 2007)",
 "BasisOfRecord is one of (Specimen, Human Observation, Observation, Machine Observation)",
 "HasCoordinate is true",
 "HasGeospatialIssue is false"
 ]
}

 The dataset includes 2 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0032556-230224095556074/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.c9usy4
title: Occurrence Download

description: A dataset containing 9 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Trachylepis pendeana (Ineich & Chirio, 2000))",
 "BasisOfRecord is one of (Specimen, Human Observation, Observation, Machine Observation)",
 "HasCoordinate is true",
 "HasGeospatialIssue is false"
 ]
}

 The dataset includes 9 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0032512-230224095556074/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.ekugpt
title: Occurrence Download

description: A dataset containing 1360 species occurrences available in GBIF matching the query:
{
 "and" : [
 "OccurrenceStatus is Present",
 "TaxonKey is Oenothera indecora Cambess."
 ]
}

 The dataset includes 1360 records from 122 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0110195-220831081235567/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.9vncqd
title: Occurrence Download

description: A dataset containing 797 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Anolis polylepis Peters, 1874)",
 "BasisOfRecord is one of (Specimen, Human Observation, Observation, Machine Observation)",
 "HasCoordinate is true",
 "HasGeospatialIssue is false"
 ]
}

 The dataset includes 797 records from 12 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0032545-230224095556074/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.7y8xwp
title: Occurrence Download

description: A dataset containing 202 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Sargassum swartzii C.Agardh, 1820"
 ]
}

 The dataset includes 202 records from 23 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0110208-220831081235567/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.f7mj2w
title: Occurrence Download

description: A dataset containing 65 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Atractus trivittatus Amaral, 1933, Atractus univittatus (Jan, 1862))",
 "BasisOfRecord is one of (Specimen, Human Observation, Observation, Machine Observation)",
 "HasCoordinate is true",
 "HasGeospatialIssue is false"
 ]
}

 The dataset includes 65 records from 8 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0032530-230224095556074/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.nvkjwh
title: Occurrence Download

description: A dataset containing 286516 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Myctophidae"
 ]
}

 The dataset includes 286516 records from 269 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0116851-220831081235567/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.y4tqzs
title: Occurrence Download

description: A dataset containing 866 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Podarcis melisellensis (Braun, 1877))",
 "BasisOfRecord is one of (Specimen, Human Observation, Observation, Machine Observation)",
 "HasCoordinate is true",
 "HasGeospatialIssue is false"
 ]
}

 The dataset includes 866 records from 13 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0032554-230224095556074/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.tjqaxt
title: Occurrence Download

description: A dataset containing 2311 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Cerithium eburneum Bruguière, 1792"
 ]
}

 The dataset includes 2311 records from 81 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0081565-220831081235567/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.3bd7vh
title: Occurrence Download

description: A dataset containing 154 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Glyptemys muhlenbergii (Schoepff, 1801))",
 "BasisOfRecord is one of (Specimen, Human Observation, Observation, Machine Observation)",
 "HasCoordinate is true",
 "HasGeospatialIssue is false"
 ]
}

 The dataset includes 154 records from 15 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0032517-230224095556074/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.s7aa23
title: Occurrence Download

description: A dataset containing 34399 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Geometry POLYGON ((-74.0257759999999934 40.6401405000000011, -74.0257759999999934 40.6424213100000031, -74.0257759999999934 40.6460706100000024, -74.0257759999999934 40.6481993599999996, -74.0257759999999934 40.6504801700000016, -74.0257759999999934 40.6539774100000031, -74.0257759999999934 40.6553459000000004, -74.0222684600000065 40.6553459000000004, -74.0189129700000024 40.6553459000000004, -74.0167776600000025 40.6553459000000004, -74.0143373100000019 40.6553459000000004, -74.0112868599999985 40.6553459000000004, -74.0089995000000016 40.6553459000000004, -74.0089995000000016 40.6523048199999977, -74.0089995000000016 40.6486555199999984, -74.0089995000000016 40.6462226599999994, -74.0089995000000016 40.6424213100000031, -74.0089995000000016 40.6401405000000011, -74.0117444299999931 40.6401405000000011, -74.0150999199999973 40.6401405000000011, -74.0178453200000064 40.6401405000000011, -74.0218108899999976 40.6401405000000011, -74.0257759999999934 40.6401405000000011))",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "Year is greater than or equal to 1932",
 "BasisOfRecord is one of (Human Observation, Living Specimen, Observation, Specimen, Machine Observation)"
 ]
}

 The dataset includes 34399 records from 6 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0088891-220831081235567/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.cb2d7u
title: Occurrence Download

description: A dataset containing 198 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is China",
 "TaxonKey is Phyllostachys edulis (Carrière) J.Houz."
 ]
}

 The dataset includes 198 records from 11 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0145886-230530130749713/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.ms6nre
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "ScientificName is Pueraria montana var. lobata",
 "HasCoordinate is true"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0088899-220831081235567/datasets/export for details.