cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.8138471.v1
title: Computational approach identifies protein off-targets for Isoniazid-NAD adduct: hypothesizing a possible drug resistance mechanism in <i>Mycobacterium tuberculosis</i>

description: Isoniazid is an important antitubercular molecule identified as a drug of choice in tuberculosis treatment. As such, INH is an inactive prodrug; it acquires an active conformation by forming an adduct with NAD. The adduct targets inhA protein, a reductase responsible for fatty acid chain elongation in the cell wall of <i>Mycobacterium tuberculosis</i>. Resistance to INH is majorly contributed by mutations in <i>inhA, katG</i> and geneic and non-geneic regions associated with efflux genes. Despite being widespread, the mechanism of resistance remains unknown in ∼15% of INH-resistant strains. Studies report that an intracellular increase in NADH concentration prevents inhA inhibition, leading to INH resistance. In the pursuit of finding possible resistance mechanisms, we set out to find NAD binding proteins to explore similarities in structure and NAD binding property of these proteins with that of inhA. We identified 172 NAD binding proteins, of which 53 were identified to have sequence or structural similarity to inhA. By performing docking analysis on selected proteins, we identified INH-adduct to have good binding affinity despite very minimal structural similarity to inhA. This analysis was further supported by principal component analysis, which identified 65 proteins with NAD binding conformation similar to that of inhA. These findings prompt us to hypothesize that upon exposure to INH, bacteria tries to reduce inhA susceptibility by inducing expression of these NAD binding proteins through increase in NADH concentration. This in turn favours off-target binding and leads to decreased binding and potency of INH, thus contributing indirectly to INH resistance. Communicated by Ramaswamy H. Sarma
DOI: 10.6084/m9.figshare.8138441
title: Supplementary Material for: Rationale of Hemoadsorption during Extracorporeal Membrane Oxygenation Support

description: Extracorporeal membrane oxygenation (ECMO) and extracorporeal life support are increasingly used for treating various forms of shock, lung failure, protected interventions and life support including resuscitation. Most patients on ECMO are affected by a systemic inflammatory response caused by the underlying disease as well as the ECMO support itself, which contributes to vasoplegia, multi-organ failure, deterioration and death. Unfortunately, effective strategies for control of inflammation and related organ failure and shock on ECMO are lacking. Recently, a new polystyrene-based device for hemoadsorption, which aims to reduce excessive levels of inflammatory molecules such as interleukins, cytokines as well as damage- and pathogen-associated molecular patterns, has become available. Here we summarize the rationale, available data and technical aspects of polystyrene-based hemoadsorption during ECMO support, and give recommendations based on existing experience.
DOI: 10.6084/m9.figshare.8138441.v2
title: Supplementary Material for: Rationale of Hemoadsorption during Extracorporeal Membrane Oxygenation Support

description: Extracorporeal membrane oxygenation (ECMO) and extracorporeal life support are increasingly used for treating various forms of shock, lung failure, protected interventions and life support including resuscitation. Most patients on ECMO are affected by a systemic inflammatory response caused by the underlying disease as well as the ECMO support itself, which contributes to vasoplegia, multi-organ failure, deterioration and death. Unfortunately, effective strategies for control of inflammation and related organ failure and shock on ECMO are lacking. Recently, a new polystyrene-based device for hemoadsorption, which aims to reduce excessive levels of inflammatory molecules such as interleukins, cytokines as well as damage- and pathogen-associated molecular patterns, has become available. Here we summarize the rationale, available data and technical aspects of polystyrene-based hemoadsorption during ECMO support, and give recommendations based on existing experience.
DOI: 10.6084/m9.figshare.8138441.v1
title: Supplementary Material for: Rationale of Hemoadsorption during Extracorporeal Membrane Oxygenation Support

description: Extracorporeal membrane oxygenation (ECMO) and extracorporeal life support are increasingly used for treating various forms of shock, lung failure, protected interventions and life support including resuscitation. Most patients on ECMO are affected by a systemic inflammatory response caused by the underlying disease as well as the ECMO support itself, which contributes to vasoplegia, multi-organ failure, deterioration and death. Unfortunately, effective strategies for control of inflammation and related organ failure and shock on ECMO are lacking. Recently, a new polystyrene-based device for hemoadsorption, which aims to reduce excessive levels of inflammatory molecules such as interleukins, cytokines as well as damage- and pathogen-associated molecular patterns, has become available. Here we summarize the rationale, available data and technical aspects of polystyrene-based hemoadsorption during ECMO support, and give recommendations based on existing experience.
DOI: 10.6084/m9.figshare.8138417
title: Supplementary Material for: Youth-Onset Type 2 Diabetes Manifestations in other Specialties: Its Many Disguises

description: <b><i>Background:</i></b> Youth-onset type 2 diabetes (T2D) is increasing in many countries, creating large personal and societal burdens. While many primary health-care professionals (HCPs) are aware of the classic symptoms of T2D, there are several other manifestations that could indicate its presence. <b><i>Summary:</i></b> This narrative review summarizes information on these symptoms and indicators, focusing on those less well known. The classic symptoms and comorbidities include frequent urination, excessive thirst, metabolic syndrome, and obesity. In addition to these, the presence of dermatological (e.g., acanthosis nigricans, granuloma annulare, necrobiosis lipoidica diabeticorum, and scleredema), gynecological (e.g., polycystic ovary syndrome, oligomenorrhea, and vulvovaginitis), hepatological (e.g., nonalcoholic fatty liver disease), and psychiatric diseases (e.g., psychosis, depression, and autism) could indicate that a patient has T2D or is at increased risk of T2D. Other less well-known indicators include abnormal blood tests (e.g., oxidized lipids, inflammation markers, hepatokines, and adipokines), prescriptions for antipsychotic medications or statins, and disrupted sleep patterns. <b><i>Key Message:</i></b> Due to the diversity of T2D manifestations in young people, primary HCPs need to remain alert to its possible presence.
DOI: 10.6084/m9.figshare.8138417.v1
title: Supplementary Material for: Youth-Onset Type 2 Diabetes Manifestations in other Specialties: Its Many Disguises

description: <b><i>Background:</i></b> Youth-onset type 2 diabetes (T2D) is increasing in many countries, creating large personal and societal burdens. While many primary health-care professionals (HCPs) are aware of the classic symptoms of T2D, there are several other manifestations that could indicate its presence. <b><i>Summary:</i></b> This narrative review summarizes information on these symptoms and indicators, focusing on those less well known. The classic symptoms and comorbidities include frequent urination, excessive thirst, metabolic syndrome, and obesity. In addition to these, the presence of dermatological (e.g., acanthosis nigricans, granuloma annulare, necrobiosis lipoidica diabeticorum, and scleredema), gynecological (e.g., polycystic ovary syndrome, oligomenorrhea, and vulvovaginitis), hepatological (e.g., nonalcoholic fatty liver disease), and psychiatric diseases (e.g., psychosis, depression, and autism) could indicate that a patient has T2D or is at increased risk of T2D. Other less well-known indicators include abnormal blood tests (e.g., oxidized lipids, inflammation markers, hepatokines, and adipokines), prescriptions for antipsychotic medications or statins, and disrupted sleep patterns. <b><i>Key Message:</i></b> Due to the diversity of T2D manifestations in young people, primary HCPs need to remain alert to its possible presence.
DOI: 10.6084/m9.figshare.8138411
title: Result of ICA and CICA

description: The datasets for the results of ICA and CICA to solve the path planning problem. Including the result table and the metadata.
DOI: 10.6084/m9.figshare.8138411.v1
title: Result of ICA and CICA

description: The datasets for the results of ICA and CICA to solve the path planning problem. Including the result table and the metadatas.
DOI: 10.6084/m9.figshare.8138408
title: Result of CICA-MO(mutation rate=0.01)

description: The datasets for the results of CICA-MO with muation rate of 0.01 to solve the path planning problem. Including the result table and the metadata.
DOI: 10.6084/m9.figshare.8138294
title: Metagenome raw count gene abundances with taxonomy

description: This datafile contains raw counts for ORFs in the co-assembly for each of the metagenome samples from 2012 at the Linnaeus Microbial Observatory site. Each ORF in this file has taxonomic annotations.
DOI: 10.6084/m9.figshare.8138294.v2
title: Metagenome raw count gene abundances with taxonomy

description: This datafile contains raw counts for ORFs in the co-assembly for each of the metagenome samples from 2012 at the Linnaeus Microbial Observatory site. Each ORF in this file has taxonomic annotations.
DOI: 10.6084/m9.figshare.8138294.v1
title: Metatranscriptome raw count gene abundances with taxonomy

description: This datafile contains raw counts for ORFs in the co-assembly for each of the metagenome samples from 2012 at the Linnaeus Microbial Observatory site. Each ORF in this file has taxonomic annotations.
DOI: 10.6084/m9.figshare.8138291
title: Metagenome raw count gene abundances

description: This datafile contains raw counts for ORFs in the co-assembly for each of the metagenome samples from 2012 at the Linnaeus Microbial Observatory site.
DOI: 10.6084/m9.figshare.8138291.v1
title: Metagenome raw count gene abundances

description: This datafile contains raw counts for ORFs in the co-assembly for each of the metagenome samples from 2012 at the Linnaeus Microbial Observatory site.
DOI: 10.6084/m9.figshare.8138285
title: Metatranscriptome raw count gene abundances with taxonomy

description: This datafile contains raw counts for ORFs in the co-assembly for each of the metatranscriptomic samples from 2012-2014 at the Linnaeus Microbial Observatory site. Each ORF in this file has taxonomic annotations.
DOI: 10.6084/m9.figshare.8138282
title: Metatranscriptome raw count gene abundances

description: This datafile contains raw counts for ORFs in the co-assembly for each of the metatranscriptomic samples from 2012-2014 at the Linnaeus Microbial Observatory site.
DOI: 10.6084/m9.figshare.8138282.v1
title: Metatranscriptome raw count gene abundances

description: This datafile contains raw counts for ORFs in the co-assembly for each of the metatranscriptomic samples from 2012-2014 at the Linnaeus Microbial Observatory site.
DOI: 10.6084/m9.figshare.8138276
title: Metatranscriptome TPM normalized gene abundances with taxonomy

description: This datafile contains TPM normalized values for ORFs in the co-assembly for each of the metatranscriptomic samples from 2012-2014 at the Linnaeus Microbial Observatory site. Each ORF in this file has taxonomic annotations.
DOI: 10.6084/m9.figshare.8138276.v1
title: Metatranscriptome TPM normalized gene abundances with taxonomy

description: This datafile contains TPM normalized values for ORFs in the co-assembly for each of the metatranscriptomic samples from 2012-2014 at the Linnaeus Microbial Observatory site. Each ORF in this file has taxonomic annotations.
DOI: 10.6084/m9.figshare.8138273
title: Metatranscriptome TPM normalized gene abundances

description: This datafile contains TPM normalized values for ORFs in the co-assembly for each of the metatranscriptomic samples from 2012-2014 at the Linnaeus Microbial Observatory site.
DOI: 10.6084/m9.figshare.8138270
title: Metagenome TPM normalized gene abundances with taxonomy

description: This datafile contains TPM normalized values for ORFs in the co-assembly for each of the metagenomic samples from 2012 at the Linnaeus Microbial Observatory site. Each ORF in this file has taxonomic annotations.
DOI: 10.6084/m9.figshare.8138264
title: Metagenome TPM normalized gene abundances

description: This datafile contains TPM normalized values for ORFs in the co-assembly for each of the metagenomic samples from 2012 at the Linnaeus Microbial Observatory site.
DOI: 10.6084/m9.figshare.8138264.v1
title: Metagenome TPM normalized gene abundances

description: This datafile contains TPM normalized values for ORFs in the co-assembly for each of the metagenomic samples from 2012 at the Linnaeus Microbial Observatory site.
DOI: 10.5281/zenodo.3969033
title: Audiovisual integration of single consonants and consonant clusters (Audiovisual dataset)

description: Audiovisual speech stimuli generated for the manuscript “Audiovisual integration of single consonants and consonant clusters.” The file “AV_stimuli.zip” contains congruent and incongruent (McGurk) audiovisual speech stimuli, which were generated with all possible audiovisual pairings of the disyllables /aba/, /aga/, /ada/, /abga/ and /abda/. The utterances were produced by a female native speaker of Swedish. The video recordings were made at a resolution of 1920 x 1080 and 30 frames per second. The sound was recorded at a bit depth of 24 bits and a sampling rate of 48 kHz.
DOI: 10.21227/rv2m-wh93
title: HUMAN4D: A Human-Centric Multimodal Dataset for Motions Immersive Media

description: We introduce HUMAN4D, a large and multimodal 4D dataset that contains a variety of human activities simultaneously captured by a professional marker-based MoCap, a volumetric capture and an audio recording system.nbsp;By capturing 2 female and 2 male professional actors performing various full-body movements and expressions, HUMAN4D provides a diverse set of motions and poses encountered as part of single- and multi-person daily, physical and social activities (jumping, dancing, etc.), along with multi-RGBD (mRGBD), volumetric and audio data.nbsp;Despite the existence of multi-view color datasets captured with the use of hardware (HW) synchronization, to the best of our knowledge, HUMAN4D is the first and only public resource that provides volumetric depth maps with high synchronization precision due to the use of intra- and inter-sensor HW-SYNC.nbsp;Moreover, a spatio-temporally aligned scanned and rigged 3D character complements HUMAN4D to enable joint research on time-varying and high-quality dynamic meshes.nbsp;We provide evaluation baselines by benchmarking HUMAN4D with state-of-the-art human pose estimation and 3D compression methods.nbsp;For the former, we apply 2D and 3D pose estimation algorithms both on single- and multi-view data cues.nbsp;For the latter, we benchmark open-source 3D codecs on volumetric data respecting online volumetric video encoding and steady bit-rates.nbsp;Furthermore, qualitative and quantitative visual comparison between mesh-based volumetric data reconstructed in different qualities showcases the available options with respect to 4D representations.nbsp;HUMAN4D is introduced to the computer vision and graphics research communities to enable joint research on spatio-temporally aligned pose, volumetric, mRGBD and audio data cues.The dataset and its code are available online.
DOI: 10.5281/zenodo.3969032
title: Audiovisual integration of single consonants and consonant clusters (Audiovisual dataset)

description: Audiovisual speech stimuli generated for the manuscript “Audiovisual integration of single consonants and consonant clusters.” The file “AV_stimuli.zip” contains congruent and incongruent (McGurk) audiovisual speech stimuli, which were generated with all possible audiovisual pairings of the disyllables /aba/, /aga/, /ada/, /abga/ and /abda/. The utterances were produced by a female native speaker of Swedish. The video recordings were made at a resolution of 1920 x 1080 and 30 frames per second. The sound was recorded at a bit depth of 24 bits and a sampling rate of 48 kHz.
DOI: 10.6084/m9.figshare.8138219
title: The SNP matrix of ten populations of Sebastiscus marmoratus

description: Based on 130 Sebastiscus marmoratus individuals sampled from 10 locations in northwestern Pacific, A total of 563,880 putative SNPs (130hc.clean.vcf) were produced among our samples and 17,653 SNPs (130new.filter.vcf) were retained following filtering steps. This dataset contains the two SNP matrix.
DOI: 10.6084/m9.figshare.8138219.v1
title: The SNP matrix of ten populations of Sebastiscus marmoratus

description: Based on 130 Sebastiscus marmoratus individuals sampled from 10 locations in northwestern Pacific, A total of 563,880 putative SNPs (130hc.clean.vcf) were produced among our samples and 17,653 SNPs (130new.filter.vcf) were retained following filtering steps. This dataset contains the two SNP matrix.
DOI: 10.24376/rd.sgul.8138174
title: Data supporting "Effect of pedometer-based walking interventions on long-term health outcomes: prospective 4-year follow-up of two randomised controlled trials using routine primary care data."

description: PACE-Lift and PACE-UP are two primary care randomised trials of effective 12-week pedometer-based walking interventions. Results from the 1-year follow-ups and 3-year (PACE-UP) and 4-year (PACE-Lift) have already been published. These data relate to further analyses of both datasets, looking at health outcomes from participants’ routine primary care records.<br><br>PACE-Lift recruited 60-75 year olds from three general practices in Berkshire and Oxfordshire from October 2011 to October 2012. Ethical approval was granted by Oxfordshire Research Ethics Committee for up to 12-month follow-up (11/H0606/2). Further ethical approval for 4-year follow-up and primary care download was later granted (14/SC0352). There was a control arm and one intervention arm who received the 12-week PACE-Lift walking intervention.<br><br>PACE-UP recruited 45-75 year olds from seven general practices in South West London from October 2012 to November 2013. Ethical approval was granted by London Hampstead Research Ethics Committee, including substantial amendments for the 3-year follow-up and subsequent primary care data download. There was a control arm and two intervention groups who both received the 12-week PACE-UP walking intervention, one group by post and the other with additional practice nurse support. These two intervention groups are combined in the current dataset.<br><br>Permission was sought from participants in both studies to access data from their primary care records for up to four years after randomisation.<br><br>We identified a priori particular long-term health outcomes in primary care records: non-fatal cardiovascular events, total cardiovascular events (cardiovascular deaths plus non-fatal cardiovascular events), new onset type 2 diabetes, new depression episodes, injurious falls and fractures. We also collected information on the number of primary care consultations and baseline prevalence of prior cardiovascular disease, diabetes and depression.<br><br>The dataset available includes variables listed below. There are restrictions on the availability of the data for this study due to the signed consent agreements around data security, which only allow access to external researchers for research monitoring purposes for both trials. Requestors wishing to access the trial data for the purposes of replicating or checking our analysis should contact the SGUL RDM service at researchdata@sgul.ac.uk.<br><br><b>Variables available</b><br><br>Demographics: sex, age, intervention group<br><br>Primary care outcomes: Length of follow-up (up to four years). Baseline cardiovascular disease, diabetes and depression. New cardiovascular events, new diagnoses of diabetes, new episodes of depression, falls, fractures and number of consultations during follow-up.<br>
DOI: 10.24376/rd.sgul.8138174.v1
title: Data supporting "Effect of pedometer-based walking interventions on long-term health outcomes: prospective 4-year follow-up of two randomised controlled trials using routine primary care data."

description: PACE-Lift and PACE-UP are two primary care randomised trials of effective 12-week pedometer-based walking interventions. Results from the 1-year follow-ups and 3-year (PACE-UP) and 4-year (PACE-Lift) have already been published. These data relate to further analyses of both datasets, looking at health outcomes from participants’ routine primary care records.<br><br>PACE-Lift recruited 60-75 year olds from three general practices in Berkshire and Oxfordshire from October 2011 to October 2012. Ethical approval was granted by Oxfordshire Research Ethics Committee for up to 12-month follow-up (11/H0606/2). Further ethical approval for 4-year follow-up and primary care download was later granted (14/SC0352). There was a control arm and one intervention arm who received the 12-week PACE-Lift walking intervention.<br><br>PACE-UP recruited 45-75 year olds from seven general practices in South West London from October 2012 to November 2013. Ethical approval was granted by London Hampstead Research Ethics Committee, including substantial amendments for the 3-year follow-up and subsequent primary care data download. There was a control arm and two intervention groups who both received the 12-week PACE-UP walking intervention, one group by post and the other with additional practice nurse support. These two intervention groups are combined in the current dataset.<br><br>Permission was sought from participants in both studies to access data from their primary care records for up to four years after randomisation.<br><br>We identified a priori particular long-term health outcomes in primary care records: non-fatal cardiovascular events, total cardiovascular events (cardiovascular deaths plus non-fatal cardiovascular events), new onset type 2 diabetes, new depression episodes, injurious falls and fractures. We also collected information on the number of primary care consultations and baseline prevalence of prior cardiovascular disease, diabetes and depression.<br><br>The dataset available includes variables listed below. There are restrictions on the availability of the data for this study due to the signed consent agreements around data security, which only allow access to external researchers for research monitoring purposes for both trials. Requestors wishing to access the trial data for the purposes of replicating or checking our analysis should contact the SGUL RDM service at researchdata@sgul.ac.uk.<br><br><b>Variables available</b><br><br>Demographics: sex, age, intervention group<br><br>Primary care outcomes: Length of follow-up (up to four years). Baseline cardiovascular disease, diabetes and depression. New cardiovascular events, new diagnoses of diabetes, new episodes of depression, falls, fractures and number of consultations during follow-up.<br>
DOI: 10.6084/m9.figshare.8138153
title: Anti-HAV decline.xlsx

description: Anti-HAV decline from 1978-79 to 2015-16 in Vojvodina<br>
DOI: 10.6084/m9.figshare.8138153.v1
title: Anti-HAV decline.xlsx

description: Anti-HAV decline from 1978-79 to 2015-16 in Vojvodina<br>
DOI: 10.6084/m9.figshare.8138150
title: Age of anti-HAV pos vs. neg.xlsx

description: Age of anti-HAV(+) vs. anti-HAV(-) in Vojvodina, Serbia
DOI: 10.6084/m9.figshare.8138150.v1
title: Age of anti-HAV pos vs. neg.xlsx

description: Age of anti-HAV(+) vs. anti-HAV(-) in Vojvodina, Serbia