cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.6198380
title: The economic impact of subthreshold and clinical childhood mental disorders

description: <i>Background</i>: Mental disorders are common health problems associated with serious impairment and economic impact. <i>Aims</i>: To estimate the costs of clinical and subthreshold mental disorders in a sample of Brazilian children. <i>Method</i>: The High Risk Cohort Study is a community study conducted in two major Brazilian cities. Subjects were 6-14 years old children being registered at school. From an initial pool of 9937 children, two subgroups were further investigated using a random-selection (<i>n</i> = 958) and high-risk group selection procedure (<i>n</i> = 1554), resulting in a sample of 2512 subjects. Mental disorder assessment was made using the Development and Well-Being Assessment. Costs for each child were estimated from the following components: mental health and social services use, school problems and parental loss of productivity. <i>Results:</i> Child subthreshold and clinical mental disorders showed lifetime mean total cost of $1750.9 and $3141.2, respectively. National lifetime cost estimate was $9.9 billion for subthreshold mental disorders and $11.6 billion for clinical mental disorders (values in US$ purchasing power parity). <i>Conclusions</i>: This study provides evidence that child mental disorders have a great economic impact on society. There is an urgent need to plan an effective system of care with cost-effective programs of treatment and prevention to reduce economic burden.
DOI: 10.6084/m9.figshare.6198380.v1
title: The economic impact of subthreshold and clinical childhood mental disorders

description: <i>Background</i>: Mental disorders are common health problems associated with serious impairment and economic impact. <i>Aims</i>: To estimate the costs of clinical and subthreshold mental disorders in a sample of Brazilian children. <i>Method</i>: The High Risk Cohort Study is a community study conducted in two major Brazilian cities. Subjects were 6-14 years old children being registered at school. From an initial pool of 9937 children, two subgroups were further investigated using a random-selection (<i>n</i> = 958) and high-risk group selection procedure (<i>n</i> = 1554), resulting in a sample of 2512 subjects. Mental disorder assessment was made using the Development and Well-Being Assessment. Costs for each child were estimated from the following components: mental health and social services use, school problems and parental loss of productivity. <i>Results:</i> Child subthreshold and clinical mental disorders showed lifetime mean total cost of $1750.9 and $3141.2, respectively. National lifetime cost estimate was $9.9 billion for subthreshold mental disorders and $11.6 billion for clinical mental disorders (values in US$ purchasing power parity). <i>Conclusions</i>: This study provides evidence that child mental disorders have a great economic impact on society. There is an urgent need to plan an effective system of care with cost-effective programs of treatment and prevention to reduce economic burden.
DOI: 10.6084/m9.figshare.6198368
title: Release-rigs with small hooks vs normal hook mounts with big hooks in fishing for baltic pike - rawdata

description: This excel-sheet contain data for contacts/landed baltic pike - plus notes on unhooking time, bleeding and size of hookwound. Predictor variables are lure type, rig and temperature. Outcome variables are landed/not landed, unhooking time (seconds), index values for bleeding and index values for size of hook wounds.
DOI: 10.6084/m9.figshare.6198368.v1
title: Release-rigs with small hooks vs normal hook mounts with big hooks in fishing for baltic pike - rawdata

description: This excel-sheet contain data for contacts/landed baltic pike - plus notes on unhooking time, bleeding and size of hookwound. Predictor variables are lure type, rig and temperature. Outcome variables are landed/not landed, unhooking time (seconds), index values for bleeding and index values for size of hook wounds.
DOI: 10.6084/m9.figshare.6198140
title: Workplace-based communication skills training in clinical departments: Examining the role of collegial relations through positioning theory

description: <b>Introduction:</b> Studies suggest that the workplace is a key to understanding how clinical communication skills learning takes place and that medical communication skills need to be reinforced over time in order not to deteriorate. This study explored the perceptions of doctors in four hospital departments who participated in a workplace-based communication training project. Its specific focus was the relationship between collegial relations and learning communication skills. <b>Methods:</b> The study applied a qualitative design using an ethnographic methodology, i.e. interviews and observations. Positioning theory was used as the theoretical framework. <b>Results:</b> Training communication skills with colleagues in the actual workplace setting was valued by the participants who experienced more sharing of communication challenges, previously understood as something private one would not share with colleagues. However, collegial relations were also barriers for providing critical feedback, especially from junior doctors to their seniors. <b>Conclusion:</b> The position as “colleague” both reinforced the communication skills training and hindered it. The communication skills educational model had a flat, non-hierarchical structure which disturbed the hierarchical structure of the workplace, and its related positions.
DOI: 10.6084/m9.figshare.6198140.v1
title: Workplace-based communication skills training in clinical departments: Examining the role of collegial relations through positioning theory

description: <b>Introduction:</b> Studies suggest that the workplace is a key to understanding how clinical communication skills learning takes place and that medical communication skills need to be reinforced over time in order not to deteriorate. This study explored the perceptions of doctors in four hospital departments who participated in a workplace-based communication training project. Its specific focus was the relationship between collegial relations and learning communication skills. <b>Methods:</b> The study applied a qualitative design using an ethnographic methodology, i.e. interviews and observations. Positioning theory was used as the theoretical framework. <b>Results:</b> Training communication skills with colleagues in the actual workplace setting was valued by the participants who experienced more sharing of communication challenges, previously understood as something private one would not share with colleagues. However, collegial relations were also barriers for providing critical feedback, especially from junior doctors to their seniors. <b>Conclusion:</b> The position as “colleague” both reinforced the communication skills training and hindered it. The communication skills educational model had a flat, non-hierarchical structure which disturbed the hierarchical structure of the workplace, and its related positions.
DOI: 10.6084/m9.figshare.6198134
title: Reproducibility, feasibility and validity of the Groningen Defecation and Fecal Continence questionnaires

description: <b>Objectives:</b> Current questionnaires on defecation disorders are often brief and fail to include questions considering causative factors. Furthermore, adult and pediatric questionnaires differ, which makes it impossible to monitor defecation disorders during the transition from childhood to adulthood. With these points in mind, we developed the Groningen Defecation and Fecal Continence (DeFeC) questionnaire and its pediatric equivalent, the P-DeFeC. The aim of this paper is to introduce the questionnaires and to assess their feasibility, reproducibility and validity. <b>Materials and methods:</b> Various Rome IV criteria and scoring tools for constipation and fecal incontinence were incorporated, resulting in nine categories. Feasibility and reproducibility were assessed by performing a test–retest survey in 100 adult participants. Concurrent validity was assessed in 27 patients and 18 healthy volunteers by comparing questionnaire-based diagnoses of constipation and fecal incontinence to final diagnoses based on anorectal function tests. <b>Results:</b> There were no remarks on the understandability of any questions. The Cohen’s kappa coefficient of all main questions ranged from 0.26 to 1.00, with an average of 0.57. All but one category showed moderate agreement or higher. The sensitivity of the questionnaire-based diagnosis of constipation was 75%; specificity was 100%. The sensitivity of the questionnaire-based diagnosis of fecal incontinence was 77%; specificity was 94%. <b>Conclusions:</b> Overall reproducibility of the Groningen DeFeC questionnaire is acceptable and its validity is good. This makes it a feasible screening tool for defecation disorders and, equally important, with these questionnaires defecation disorders can now be monitored during the transition from childhood to adulthood.
DOI: 10.6084/m9.figshare.6198134.v1
title: Reproducibility, feasibility and validity of the Groningen Defecation and Fecal Continence questionnaires

description: <b>Objectives:</b> Current questionnaires on defecation disorders are often brief and fail to include questions considering causative factors. Furthermore, adult and pediatric questionnaires differ, which makes it impossible to monitor defecation disorders during the transition from childhood to adulthood. With these points in mind, we developed the Groningen Defecation and Fecal Continence (DeFeC) questionnaire and its pediatric equivalent, the P-DeFeC. The aim of this paper is to introduce the questionnaires and to assess their feasibility, reproducibility and validity. <b>Materials and methods:</b> Various Rome IV criteria and scoring tools for constipation and fecal incontinence were incorporated, resulting in nine categories. Feasibility and reproducibility were assessed by performing a test–retest survey in 100 adult participants. Concurrent validity was assessed in 27 patients and 18 healthy volunteers by comparing questionnaire-based diagnoses of constipation and fecal incontinence to final diagnoses based on anorectal function tests. <b>Results:</b> There were no remarks on the understandability of any questions. The Cohen’s kappa coefficient of all main questions ranged from 0.26 to 1.00, with an average of 0.57. All but one category showed moderate agreement or higher. The sensitivity of the questionnaire-based diagnosis of constipation was 75%; specificity was 100%. The sensitivity of the questionnaire-based diagnosis of fecal incontinence was 77%; specificity was 94%. <b>Conclusions:</b> Overall reproducibility of the Groningen DeFeC questionnaire is acceptable and its validity is good. This makes it a feasible screening tool for defecation disorders and, equally important, with these questionnaires defecation disorders can now be monitored during the transition from childhood to adulthood.
DOI: 10.6084/m9.figshare.6198131
title: Additional file 3: of Simple paired heavy- and light-chain antibody repertoire sequencing using endoplasmic reticulum microsomes

description: Contains supplementary data files 1–4. (XLSX 71 kb)
DOI: 10.6084/m9.figshare.6198131.v1
title: Additional file 3: of Simple paired heavy- and light-chain antibody repertoire sequencing using endoplasmic reticulum microsomes

description: Contains supplementary data files 1–4. (XLSX 71 kb)
DOI: 10.6084/m9.figshare.6198128
title: Additional file 2: of Simple paired heavy- and light-chain antibody repertoire sequencing using endoplasmic reticulum microsomes

description: Contains supplementary data files 1–6. (XLSX 1059 kb)
DOI: 10.6084/m9.figshare.6198128.v1
title: Additional file 2: of Simple paired heavy- and light-chain antibody repertoire sequencing using endoplasmic reticulum microsomes

description: Contains supplementary data files 1–6. (XLSX 1059 kb)
DOI: 10.6084/m9.figshare.6198101
title: Additional file 9: of Transcriptional profiling of human bronchial epithelial cell BEAS-2B exposed to diesel and biomass ultrafine particles

description: Table S5. Functional enrichment of gene sets from GSEA Hallmarks collection in cells exposed to diesel UFP. (XLS 48Â kb)
DOI: 10.6084/m9.figshare.6198101.v1
title: Additional file 9: of Transcriptional profiling of human bronchial epithelial cell BEAS-2B exposed to diesel and biomass ultrafine particles

description: Table S5. Functional enrichment of gene sets from GSEA Hallmarks collection in cells exposed to diesel UFP. (XLS 48Â kb)
DOI: 10.6084/m9.figshare.6198089
title: Additional file 7: of Transcriptional profiling of human bronchial epithelial cell BEAS-2B exposed to diesel and biomass ultrafine particles

description: Table S4. Fold change of genes differentially expressed by the exposure to both diesel and biomass UFP. (XLS 67Â kb)
DOI: 10.6084/m9.figshare.6198089.v1
title: Additional file 7: of Transcriptional profiling of human bronchial epithelial cell BEAS-2B exposed to diesel and biomass ultrafine particles

description: Table S4. Fold change of genes differentially expressed by the exposure to both diesel and biomass UFP. (XLS 67Â kb)
DOI: 10.6084/m9.figshare.6198083
title: Additional file 6: of Transcriptional profiling of human bronchial epithelial cell BEAS-2B exposed to diesel and biomass ultrafine particles

description: Table S3. FC and p-value of the genes differentially expressed after exposure to UFP from biomass combustion (as compared to controls) at the different time points. (XLS 3855Â kb)
DOI: 10.6084/m9.figshare.6198083.v1
title: Additional file 6: of Transcriptional profiling of human bronchial epithelial cell BEAS-2B exposed to diesel and biomass ultrafine particles

description: Table S3. FC and p-value of the genes differentially expressed after exposure to UFP from biomass combustion (as compared to controls) at the different time points. (XLS 3855Â kb)
DOI: 10.6084/m9.figshare.6198077
title: Additional file 5: of Transcriptional profiling of human bronchial epithelial cell BEAS-2B exposed to diesel and biomass ultrafine particles

description: Table S2. FC and p-value of the genes differentially expressed after exposure to UFP from diesel combustion (as compared to controls) at the different time points. (XLS 3855Â kb)
DOI: 10.6084/m9.figshare.6198077.v1
title: Additional file 5: of Transcriptional profiling of human bronchial epithelial cell BEAS-2B exposed to diesel and biomass ultrafine particles

description: Table S2. FC and p-value of the genes differentially expressed after exposure to UFP from diesel combustion (as compared to controls) at the different time points. (XLS 3855Â kb)
DOI: 10.6084/m9.figshare.6198053
title: Additional file 3: of Transcriptional profiling of human bronchial epithelial cell BEAS-2B exposed to diesel and biomass ultrafine particles

description: Table S1. Total number of reads and number and percentage of reads mapped by TopHat in each analyzed sample. (XLS 39Â kb)
DOI: 10.6084/m9.figshare.6198053.v1
title: Additional file 3: of Transcriptional profiling of human bronchial epithelial cell BEAS-2B exposed to diesel and biomass ultrafine particles

description: Table S1. Total number of reads and number and percentage of reads mapped by TopHat in each analyzed sample. (XLS 39Â kb)
DOI: 10.6084/m9.figshare.6198038
title: Additional file 3: of Conservation of the separase regulatory domain

description: Table: Proteins corresponding to the separase N-terminal domain in Insecta. Truncated sequence is highlighted in grey; sequences missing the CxCxxC motif are highlighted in yellow. (XLSX 15 kb)
DOI: 10.6084/m9.figshare.6198038.v1
title: Additional file 3: of Conservation of the separase regulatory domain

description: Table: Proteins corresponding to the separase N-terminal domain in Insecta. Truncated sequence is highlighted in grey; sequences missing the CxCxxC motif are highlighted in yellow. (XLSX 15 kb)
DOI: 10.6084/m9.figshare.6198023
title: Additional file 2: of Conservation of the separase regulatory domain

description: Table: Separases in representatives of major metazoan phyla. Products of two genes corresponding to N-terminal and C-terminal separase domains are highlighted in yellow and green, respectively. Truncated sequences are highlighted in grey. (XLSX 14 kb)
DOI: 10.6084/m9.figshare.6198023.v1
title: Additional file 2: of Conservation of the separase regulatory domain

description: Table: Separases in representatives of major metazoan phyla. Products of two genes corresponding to N-terminal and C-terminal separase domains are highlighted in yellow and green, respectively. Truncated sequences are highlighted in grey. (XLSX 14 kb)
DOI: 10.6084/m9.figshare.6197999
title: Additional file 1: of Diapause in a tropical oil-collecting bee: molecular basis unveiled by RNA-Seq

description: Tables presenting the differentially expressed transcripts and gene annotation results. (XLSX 413 kb)
DOI: 10.6084/m9.figshare.6197999.v1
title: Additional file 1: of Diapause in a tropical oil-collecting bee: molecular basis unveiled by RNA-Seq

description: Tables presenting the differentially expressed transcripts and gene annotation results. (XLSX 413 kb)
DOI: 10.6084/m9.figshare.6197984
title: Additional file 14: of Transcriptional profiling of human bronchial epithelial cell BEAS-2B exposed to diesel and biomass ultrafine particles

description: Table S9. Biological interactions of genes from network analysis (Fig. 4 and AdditionalÂ fileÂ 15: Figure S6) according to the Reactome FI database; for each interaction, the type of regulation and the score are indicated. Scores range from 0 to 0.99 for predicted while are equal to 1 for manually annotated interactions. (XLS 123Â kb)
DOI: 10.6084/m9.figshare.6197984.v1
title: Additional file 14: of Transcriptional profiling of human bronchial epithelial cell BEAS-2B exposed to diesel and biomass ultrafine particles

description: Table S9. Biological interactions of genes from network analysis (Fig. 4 and AdditionalÂ fileÂ 15: Figure S6) according to the Reactome FI database; for each interaction, the type of regulation and the score are indicated. Scores range from 0 to 0.99 for predicted while are equal to 1 for manually annotated interactions. (XLS 123Â kb)
DOI: 10.6084/m9.figshare.6197975
title: Additional file 13: of Transcriptional profiling of human bronchial epithelial cell BEAS-2B exposed to diesel and biomass ultrafine particles

description: Table S8. Detail of the filtering criteria for each of the DEGs from network analysis (Fig. 4); for each gene, the number of significant time points, presence in the core enrichment of the selected GSEA hallmarks or the number of Pubmed publications with cardiovascular diseases, lung cancer, or lung diseases terms are indicated. (XLS 78Â kb)
DOI: 10.6084/m9.figshare.6197975.v1
title: Additional file 13: of Transcriptional profiling of human bronchial epithelial cell BEAS-2B exposed to diesel and biomass ultrafine particles

description: Table S8. Detail of the filtering criteria for each of the DEGs from network analysis (Fig. 4); for each gene, the number of significant time points, presence in the core enrichment of the selected GSEA hallmarks or the number of Pubmed publications with cardiovascular diseases, lung cancer, or lung diseases terms are indicated. (XLS 78Â kb)
DOI: 10.6084/m9.figshare.6197963
title: Additional file 8: of Analysis of Theileria orientalis draft genome sequences reveals potential species-level divergence of the Ikeda, Chitose and Buffeli genotypes

description: Proteins with no blastp matches compared to reference genome. Examination of proteins that produced no blastp match to the Shintoku predicted proteome, by blastp searches of the nr database. (XLSX 13 kb)
DOI: 10.6084/m9.figshare.6197963.v1
title: Additional file 8: of Analysis of Theileria orientalis draft genome sequences reveals potential species-level divergence of the Ikeda, Chitose and Buffeli genotypes

description: Proteins with no blastp matches compared to reference genome. Examination of proteins that produced no blastp match to the Shintoku predicted proteome, by blastp searches of the nr database. (XLSX 13 kb)
DOI: 10.6084/m9.figshare.6197942
title: Additional file 11: of Transcriptional profiling of human bronchial epithelial cell BEAS-2B exposed to diesel and biomass ultrafine particles

description: Table S7. Genes identified by maSigPro as differentially modulated in time during the exposure to biomass or diesel UFP, respectively. (XLS 66Â kb)
DOI: 10.6084/m9.figshare.6197942.v1
title: Additional file 11: of Transcriptional profiling of human bronchial epithelial cell BEAS-2B exposed to diesel and biomass ultrafine particles

description: Table S7. Genes identified by maSigPro as differentially modulated in time during the exposure to biomass or diesel UFP, respectively. (XLS 66Â kb)
DOI: 10.6084/m9.figshare.6197924
title: Additional file 10: of Transcriptional profiling of human bronchial epithelial cell BEAS-2B exposed to diesel and biomass ultrafine particles

description: Table S6. Functional enrichment of gene sets from GSEA Hallmarks collection in cells exposed to biomass UFP. (XLS 49Â kb)
DOI: 10.6084/m9.figshare.6197924.v1
title: Additional file 10: of Transcriptional profiling of human bronchial epithelial cell BEAS-2B exposed to diesel and biomass ultrafine particles

description: Table S6. Functional enrichment of gene sets from GSEA Hallmarks collection in cells exposed to biomass UFP. (XLS 49Â kb)
DOI: 10.6084/m9.figshare.6197918
title: Additional file 2: of Telomerase regulation by the long non-coding RNA H19 in human acute promyelocytic leukemia cells

description: Table S2. Data analysis of the microarray experiments. Lists of genes with significant differential expression levels (fold changes of ±2 fold; p
DOI: 10.6084/m9.figshare.6197918.v1
title: Additional file 2: of Telomerase regulation by the long non-coding RNA H19 in human acute promyelocytic leukemia cells

description: Table S2. Data analysis of the microarray experiments. Lists of genes with significant differential expression levels (fold changes of ±2 fold; p
DOI: 10.6084/m9.figshare.6197906
title: Additional file 4: of Individual odour signatures that mice learn are shaped by involatile major urinary proteins (MUPs)

description: GC-MS analysis used for Fig. 7. Peak areas for the four male-specific volatiles measured from a pool of C57BL/6 urine when different recombinant MUPs or buffer only was added, together with duration of storage prior to analysis. (XLS 32Â kb)
DOI: 10.6084/m9.figshare.6197906.v1
title: Additional file 4: of Individual odour signatures that mice learn are shaped by involatile major urinary proteins (MUPs)

description: GC-MS analysis used for Fig. 7. Peak areas for the four male-specific volatiles measured from a pool of C57BL/6 urine when different recombinant MUPs or buffer only was added, together with duration of storage prior to analysis. (XLS 32Â kb)
DOI: 10.6084/m9.figshare.6197900
title: Additional file 5: of Development of a computational promoter with highly efficient expression in tumors

description: The genes function of protein-protein interaction with NF-κB, CREB, HIF-1α. (XLSX 14 kb)
DOI: 10.6084/m9.figshare.6197900.v1
title: Additional file 5: of Development of a computational promoter with highly efficient expression in tumors

description: The genes function of protein-protein interaction with NF-κB, CREB, HIF-1α. (XLSX 14 kb)
DOI: 10.6084/m9.figshare.6197888
title: Additional file 3: of Individual odour signatures that mice learn are shaped by involatile major urinary proteins (MUPs)

description: GC-MS analysis used for Fig. 6. Peak areas and principal component scores for the four male-specific volatiles measured from BALB/c urine, C57BL/6 urine and BALB/c urine + r-darcin. (XLS 31Â kb)