cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.8195216.v1
title: Satisfaction of family members of critically ill patients admitted to a public hospital intensive care unit and correlated factors

description: ABSTRACT  Objective: To analyze the satisfaction, medical situation understanding and symptoms of anxiety and depression in family members of patients admitted to the intensive care unit.  Methods: The family members of patients who were hospitalized for ≥ 72 hours were invited to participate in the study, which was performed in a public hospital. Questionnaires were answered to assess the understanding of the diagnosis, treatment and prognosis, and the support received in the intensive care unit. The family needs were also evaluated using a modified version of the Critical Care Family Needs Inventory (CCFNI). The Hospital Anxiety and Depression Scale (HADS) was used to assess the symptoms of anxiety and depression.  Results: A total of 35 family members were interviewed within the patients' first week of stay in the intensive care unit. Most patients (57.1%) were male, aged 54 ± 19 years. Sepsis was the main reason for admission to the intensive care unit (40%); the median of the Simplified Acute Physiology Score (SAPS) 3 was 68 (48 - 77), and 51.4% of the patients died in the intensive care unit. The majority of the family members were female (74.3%) and were sons or daughters of patients (54.3%), with a mean age of 43.2 ± 14 years. Overall, 77.1% of the family members were satisfied with the intensive care unit. A total of 37.1% of the family members did not understand the prognosis. Receiving clear and complete information in the intensive care unit and the doctor being accessible were factors that were significantly correlated with the overall family satisfaction. The prevalence of symptoms of anxiety (60%) and depression (54.3%) in the family members was high.  Conclusion: The emotional distress of family members is high during a patient's hospitalization in the intensive care unit, although satisfaction is also high. Clear and complete information provided by the intensivist and the support received in the intensive care unit are significantly correlated with the satisfaction of family members in a public hospital.
DOI: 10.6084/m9.figshare.8195222
title: Clinical and epidemiological characteristics of whooping cough in hospitalized patients of a tertiary care hospital in Peru

description: ABSTRACT  Objective: Describe the clinical and epidemiological characteristics of patients under 2 years of age hospitalized with whooping cough in a tertiary care children's hospital in Peru.  Methods: This was a case series of patients under 2 years of age who were hospitalized with a diagnosis of whooping cough in 2012.  Results: A total of 121 patients were hospitalized. Diagnostic testing (direct immunofluorescence, polymerase chain reaction, culture) was carried out in 53.72% of patients. Overall, 23.15% (n = 28) were confirmed cases, all of whom were patients less than 10 months old, and none of whom had received 3 doses of whooping cough vaccine. A total of 96.43% (n = 27) of cases were under 6 months of age, 42.86% (n = 12) were younger than 3 months, and 10.71% (n = 3) were admitted to the intensive care unit. Of these cases, all were younger than 2 months old, and one patient died. The most common symptoms in the confirmed cases were coughing (96.43%), facial redness (96.43%), paroxysmal coughing (92.86%), and coughing-related cyanosis (78.57%). The most frequent probable epidemiological contact was the mother (17.86%), and the majority of cases occurred in the summer (46.43%).  Conclusion: Whooping cough is a cause of morbidity and mortality, especially in those younger than 6 months of age and in those who are not immunized or only partially immunized. Vaccination rates should be improved and case confirmation encouraged to prevent the underdiagnosis of this disease.
DOI: 10.6084/m9.figshare.8195228
title: Is moderate hypofractionation accepted as a new standard of care in north america for prostate cancer patients treated with external beam radiotherapy? Survey of genitourinary expert radiation oncologists

description: ABSTRACT  Introduction: Several recent randomized clinical trials have evaluated hypofractionated regimens against conventionally fractionated EBRT and shown similar effectiveness with conflicting toxicity results. The current view regarding hypofractionation compared to conventional EBRT among North American genitourinary experts for management of prostate cancer has not been investigated.  Materials and Methods: A survey was distributed to 88 practicing North American GU physicians serving on decision - making committees of cooperative group research organizations. Questions pertained to opinions regarding the default EBRT dose and fractionation for a hypothetical example of a favorable intermediate - risk prostate cancer (Gleason 3 + 4). Treatment recommendations were correlated with practice patterns using Fisher's exact test.  Results: Forty - two respondents (48%) completed the survey. We excluded from analysis two respondents who selected radical hypofractionation with 5 – 12 fractions as a preferred treatment modality. Among the 40 analyzed respondents, 23 (57.5%) recommend conventional fractionation and 17 (42.5%) recommended moderate hypofractionation. No demographic factors were found to be associated with preference for a fractionation regimen. Support for brachytherapy as a first choice treatment modality for low - risk prostate cancer was borderline significantly associated with support for moderate hypofractionated EBRT treatment modality (p = 0.089).  Conclusions: There is an almost equal split among North American GU expert radiation oncologists regarding the appropriateness to consider moderately hypofractionated EBRT as a new standard of care in management of patients with prostate cancer. Physicians who embrace brachytherapy may be more inclined to support moderate hypofractionated regimen for EBRT. It is unclear whether reports with longer follow-ups will impact this balance, or whether national care and reimbursement policies will drive the clinical decisions. In the day and age of patient - centered care delivery, patients should receive an objective recommendation based on available clinical evidence. The stark division among GU experts may influence the design of future clinical trials utilizing EBRT for patients with prostate cancer.
DOI: 10.6084/m9.figshare.8195231
title: Quality of Life in Women with Defecatory Dysfunctions: Systematic Review of Questionnaires Validated in the Portuguese Language

description: Abstract  Objective  To identify the quality of life (QoL) assessment instruments related to the health of women with fecal incontinence (FI) or anal incontinence (AI).  Data Sources  Systematic review conducted in the Virtual Health Library (VHL), PubMed and Cochrane Library databases. The descriptors used were: Questionnaire, Questionnaires, Quality of life, validation, validation Studies, anal incontinence, fecal incontinence and constipation. The search was performed between December 26, 2017 and the beginning of January 2018. The limits used were female gender.  Selection of Studies  Initially, 5,143 articles were obtained in the search. The articles of validation for Portuguese of questionnaires for the evaluation of the impact of FI/AI on the QoL of women were considered eligible.  Data Collection  The article search was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyzes (PRISMA) guidelines.  Data Synthesis  Of the 5,143 articles, only 2 fulfilled the inclusion and exclusion criteria: Fecal Incontinence Quality of Life (FIQL) and the Wexner scale (WS). The FIQL evaluates the QoL related to FI, not covering flatus incontinence. The WS assesses flatus incontinence and the severity of the AI. The WS obtained an interclass correlation coefficient (ICC) of 0.932 and a Cronbach α coefficient &gt; 0.90. The FIQL obtained intraexaminer and interexaminer reproducibility ranging from 0.929 to 0.957 and from 0.944 to 0.969, respectively.  Conclusions  The WS and the FIQL have satisfactory reliability and validity for use during gynecological consultations.
DOI: 10.6084/m9.figshare.8195237.v1
title: Alcoholic extract of propolis in Nile tilapia post-larvae and fingerlings’ diets: effects on production performance, body composition and intestinal histology

description: Abstract: The aim of this study was to evaluate the production performance of Nile tilapia post-larvae and fingerlings fed with increasing levels of alcoholic extract of propolis into diets. In Experiment 1, 1800 post-larvae were distributed in 30 tanks, in a completely randomized design with five treatments composed by the inclusion of 0, 1, 2, 3 and 4 g of dry propolis/kg of feed, and six replicates. In experiment 2, 1600 fingerlings were distributed in the same system and designed as experiment 1. No significant effect was observed between treatments, for final weight, total and standard length, survival, and intestinal villus height. However, the propolis extract inclusion of 1 g/kg in Nile tilapia post-larvae and fingerlings’ feed resulted in a better body condition factor and higher body protein deposition (p&lt;0.05). The condition factor is an estimate for the future growth of the animals, possibly the fish treated with propolis extract will present better growth, survival and greater reproductive potential rates. The results of the present study demonstrate that alcoholic extract of propolis improves the nutritional condition of Nile tilapia post-larvae and fingerlings, potentially leading to increased productivity in subsequent stages, as well as leading to improvement in fingerlings muscle deposition.
DOI: 10.6084/m9.figshare.8195240.v1
title: The compound, diallyl disulfide, enriched in garlic, prevents the progression of doxorubicin-induced nephropathy

description: Abstract The main medicinal property of garlic is mostly attributed to its organosulfur compounds, of which the oil-soluble diallyl disulfide (DADS) is the principal component of distilled garlic oil. Nuclear factor erythroid 2-related factor 2 (Nrf2) is an important cellular regulator in response to oxidative stress. This study assessed the possible protective effect of DADS on doxorubicin (Dox)-induced nephrotoxicity and its potential regulation of the Nrf2 pathway. Treatment with DADS (200 μM) induced heme oxygenase (HO)-1 and NADPH quinone oxidoreductase 1 (NQO-1) expression in a human proximal tubular cell line. The induction of HO-1 expression was suppressed in Nrf2-silenced cells. In an animal study, pretreatment with DADS relieved Dox-induced albuminuria, increased catalase activity, and reduced the urinary 8-hydroxy-2'-deoxyguanosine level. In addition, DADS ameliorated the severity of glomerulosclerosis and suppressed expressions of fibrotic and inflammatory gene expressions. Our data indicate that DADS, a major component of garlic, showed protective effects of preventing the progression of Dox-induced nephropathy through enhancing Nrf2-mediated antioxidant activity. DADS, a normal constituent of the human diet, merits investigation as a potential antioxidant daily food supplement against free radical-mediated chronic diseases.
DOI: 10.6084/m9.figshare.8195246.v1
title: Clinical Features and Management of Women with Borderline Ovarian Tumors in a Single Center in Brazil

description: Abstract  Objective  The aim of the present study was to describe and analyze data of 57 women with borderline ovarian tumors (BOTs) regarding histological characteristics, clinical features and treatment management at the Department of Obstetrics and Gynecology of the Universidade Estadual de Campinas (Unicamp, in the Portuguese acronym).  Methods  The present retrospective study analyzed data obtained from clinical and histopathological reports of women with BOTs treated in a single cancer center between 2010 and 2018.  Results  A total of 57 women were included, with a mean age of 48.42 years old (15.43- 80.77), of which 30 (52.63%) were postmenopausal, and 18 (31.58%) were &lt; 40 years old. All of the women underwent surgery. A total of 37 women (64.91%) were submitted to complete surgical staging for BOT, and none (0/57) were submitted to pelvic or paraortic lymphadenectomy. Chemotherapy was administered for two patients who recurred. The final histological diagnoses were: serous in 20 (35.09%) cases, mucinous in 26 (45.61%), seromucinous in 10 (17.54%), and endometrioid in 1 (1.75%) case. Intraoperative analyses of frozen sections were obtained in 42 (73.68%) women, of which 28 (66.67%) matched with the final diagnosis. The mean follow-up was of 42.79 months (range: 2.03-104.87 months). Regard ingthe current status of the women, 45(78.95%) are alive without disease, 2(3.51%) arealive with disease, 9 (15.79%) had their last follow-up visit &gt; 1 year beforethe performanceof the present study but arealive, and 1 patient(1.75%) died of another cause.  Conclusion  Women in the present study were treated according to the current guidelines and only two patients recurred.
DOI: 10.6084/m9.figshare.8195258
title: Combinatorial analysis of agronomic characters in soybean

description: ABSTRACT Evaluation of the genetic potential of parent plants is fundamental for obtaining superior populations with desirable agronomic characters. The aim of this work was to obtain estimates of the general and specific combining abilities of five soybean parents to identify the most promising parents and hybrid combinations for the development of superior genotypes for grain yield. In this study, two groups of soybean cultivars were selected: group I resistance (UFUS 7910 and BR/MG 46 Conquista) and group II (TMG 4182, TMG 4185 and BRSGO Chapadões). The parents were crossedin a 2 x 3 partial diallel scheme, and the experiment was analyzed according to Griffing’s (1956) parent and F1 model and adapted by Geraldi and Miranda Filho (1988). Six hybrid combinations and respective parents were arranged in randomized complete blocks with four repetitions. The following characters were evaluated: number of days for flowering and maturity, height of the plant in flowering and at maturity, number of nodes in flowering and at maturity, number of total pods and grain yield per plant. The BR/MG 46 Conquista, UFUS 7910 and BRSGO Chapadões parents contributed to obtaining productive segregant populations due to additivity for the total number of pods and grain yield per plant. The hybrid combinations BRSGO Chapadões x BR/MG 46 Conquista, BRSGO Chapadões x UFUS 7910 and TMG4182 x BR/MG 46 Conquista are promising for obtaining populations with high productive potential.
DOI: 10.6084/m9.figshare.8195267.v1
title: Ingestion of a drink containing carbohydrate increases the number of bench press repetitions

description: ABSTRACT  Objective The aim of this study was to analyze the effects of carbohydrate ingestion prior to exercise on the number of bench press repetitions.  Methods Eight male physically active (21.3±2.7 years, 176±5cm, 73.12±6.12kg), with a minimum experience of at least one year exercising regularly, visited the laboratory at three moments. During the first visit, candidates went through their anthropometric evaluation and the application of their maximum number of bench press repetitions. The experimental tests were performed during their second and third visits in a crossover and blind study. The participants performed the maximum number of repetitions with an intensity of 70% of their maximum repetition strength. One hour before the experimental trials, participants randomly ingested a solution containing either carbohydrate or a placebo.  Results The ingestion of carbohydrate increases muscle resistance in relation to placebo (p=0.014; effect size=0.71). This is evidenced by the increase in the number of repetitions (12.9±2.4 and 11.3±1.9, respectively). The individual’s perception of effort is higher in the carbohydrate group than in the placebo group after exhaustion (4±0.93 and 3.1±0.64, respectively, p=0.006, effect size=0.89).  Conclusion It is concluded that a previous intake of carbohydrate is useful in improving performance in resistance exercises, providing an increase in the individual’s perception of effort.
DOI: 10.6084/m9.figshare.8195123.v1
title: Medical Student’s Knowledge of Ophthalmology

description: ABSTRACT This research was based on a descriptive study, aimed at evaluating medical students’ knowledge about Ophthalmology. A questionnaire composed of 20 questions was applied through the Survey Monkey app, which were answered by 1st- to 6th- year medical students. Based on the data collected, it was found that there is an increase in the level of knowledge about Ophthalmology according to the- year of study (5th and 6th year students have greater ownership of the subject) and also students who opted for Ophthalmology as a future specialization. Furthermore, another important finding was that although the students are aware of important ophthalmologic pathologies, they are not fully familiar with the management of emergencies and ophthalmologic procedures as general practitioners in the Emergency Room.
DOI: 10.6084/m9.figshare.8195126
title: On mechanical vibration analysis of a multi degree of freedom system based on arduino and MEMS accelerometers

description: This paper is aimed at undergraduate students of physics, engineering and mathematics, where a methodology for mechanical vibration analysis of a multi degree of freedom (DOF) excited by an harmonic force in the time and frequency domain is presented. The Arduino microcontroller is used as an acquisition system and low-cost MEMS accelerometers for the instrumentation of the system. System of multi DOF are studied in a great number of problems in mechanical sciences, however its experimental study is not always present in the courses due to the high costs and complexity. These problems are overpassed with the study proposed in this work. Besides, the application presented has an interface with several disciplines in undergraduation and graduation level. The method proposed can be easy implemented and the results obtained had good precision and are in agreement with the literature.
DOI: 10.6084/m9.figshare.8195144
title: Can quadrivalent human papillomavirus prophylactic vaccine be an effective alternative for the therapeutic management of genital warts? an exploratory study

description: ABSTRACT  Objective: To evaluate the treatment effect of genital warts, we investigated the quadrivalent HPV vaccine injection compared with surgical excision.  Materials and Methods: This prospective study included 26 patients (M:F = 24:2) who received HPV vaccine or surgical excision. After explanation of surgical excision or HPV vaccine, 16 patients underwent surgical excision and the others received HPV vaccine injections. Based on gross findings of genital warts, treatment outcomes were classified as complete response (no wart), partial response, and failed treatment.  Results: Among enrolled patients, 42% (11 / 26) patients had recurrent genital warts. In vaccination group, complete response rates of genital wart were 60% following 3 times HPV vaccine. Partial response patients wanted to excise the genital lesions before the 3 times injection, because they worried about sexual transmission of disease to their sexual partners. One patient underwent surgical excision after 3 times injection. Excision sites included suprapubic lesions, but other sites including mid-urethra and glans showed complete response after injection. At a mean follow-up period of 8.42 ± 3.27 months, 10 patients (100%) who received HPV vaccine did not show recurrence.  Conclusion: The response rates after HPV vaccine injection were 90% (complete and partial). Our results suggested that HPV vaccines could be effective in management of genital warts.
DOI: 10.6084/m9.figshare.8195147
title: Perspectives and Applications of Natural Products as Civilian Defense Devices

description: Civilian defense devices are physical and chemical artefacts used to incapacitate an aggressor without causing death or injury. As city violence increases, safety feelings became worst and a growing commercial demand for these materials supply faces technologically challenges not only to riot control but also to self-protection. Controversies on the use of these devices have been discussed, especially on their toxicity when synthetic chemical agents are used. Natural metabolites are a less explored alternative to meet this demand. They have the capacity to generate a temporary disabling effect due to their pungency. Those metabolites, which include capsaicinoids, gingerols and piperine, can be used as deterrent agents in civilian defense devices due to their low toxicity to humans. Although they are a viable alternative, there are few studies focused on their quality control, efficiency and toxicity. This review aimed to present relevant aspects about the development and use of natural products as deterrent agents in self-defense devices against aggressors and animals, and as non-lethal weapons for riot control in order to help the scientific development of this type of bioproduct.
DOI: 10.6084/m9.figshare.8195150
title: Initial experience of video endoscopic inguinal Lymphadenectomy in a center located at northeast brazilian region

description: ABSTRACT  Introduction: Video endoscopic inguinal lymphadenectomy – VEIL – has emerged as an alternative to reduce post-surgical complications (PSC) in patients with penile cancer submitted to inguinal lymphadenectomy (IL). In some series, these PSC are observed in more than 50% of patients. The objectives of the present study are to describe the initial experience of VEIL in a Hospital in Teresina, PI, Brazil, and to analyze PSC incidence.  Material and Methods: Retrospective descriptive study of patients submitted to VEIL from March 2014 to November 2015. Data were collected regarding surgical time, bleeding, complications, lymph node number, conversion, global complications, drainage time, cellulitis, lymphocele, cutaneous necrosis, miocutaneous necrosis and hospitalization time.  Results: 20 lower limbs of 11 patients were operated. Mean age was 51.4 (24-72) years. Mean surgical time was 85 (60-120) minutes. No patient showed intrasurgical complications, bleeding &gt; 50 mL or conversion. Three surgeries evolved with lower limb edema, 2 with lymphoceles and one patient had cutaneous necrosis and another bulging of surgical wound. Mean time of hospitalization was 4 (2-11) days. A mean of 5.8 (1-12) lymph nodes were dissected in each surgery.  Conclusion: VEIL is a safe and easy technique with lower incidence of PSC that can be reproduced in small centers.
DOI: 10.6084/m9.figshare.8195159.v1
title: Primary renal angiosarcoma with extensive hemorrhage: CT and MRI findings

description: ABSTRACT Primary angiosarcomas of the kidney are very rare, but highly aggressive tumors showing poor prognosis. Patients frequently complain of flank pain, hematuria, or a palpable mass. We present a case of primary renal angiosarcoma occurring in a 61-year-old man. CT images depicted a huge exophytic mass (16 cm in diameter) in the right kidney, exhibiting extensive hemorrhage. The mass showed centripetal peripheral nodular enhancement on dynamic contrast-enhanced images. Furthermore, MR imaging revealed a tangled mesh of tumor vessels in the periphery of the mass. We suggest its inclusion in the differential diagnosis of cases of hemorrhagic renal tumors with prominent vasculature.