cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.26068/mhhrpm/20240905-000
title: Cystinosis-Associated Metabolic Bone Disease Across Ages and CKD Stages 1 to 5D/T

description: Supplemental Material zu folgender Publikation (Abstract) Context: The pathophysiology of cystinosis-associated metabolic bone disease is complex. Objective: We hypothesized a disturbed interaction between osteoblasts and osteoclasts. Methods: This binational cross-sectional multicenter study included 103 patients with cystinosis (61% children) with chronic kidney disease (CKD) stages 1 to 5D/T at hospital clinics. Ten key bone markers were evaluated. Results: Skeletal complications occurred in two-thirds of the patients, with adults having a 5-fold increased risk compared with children. Patients with CKD stages 1 to 3 showed reduced z-scores for serum phosphate and calcium and suppressed fibroblast growth factor 23 (FGF23) and parathyroid hormone levels, in conjunction with elevated bone-specific alkaline phosphatase levels. Serum phosphate was associated with estimated glomerular filtration rate, combined phosphate and active vitamin D treatment, and native vitamin D supplementation, while serum calcium was associated with age and dosage of active vitamin D. Sclerostin was generally elevated in children, and associated with age, FGF23 levels, and treatment with active vitamin D and growth hormone. The osteoclast marker tartrate-resistant acid phosphatase 5b was increased, and associated with age and treatment with active vitamin D. The ratio of soluble ligand of receptor activator of nuclear factor-κB (sRANKL) and osteoprotegerin (OPG), a surrogate for the regulation of osteoclastogenesis by osteoblasts, was decreased and associated with phosphate and 1,25(OH)2D3 levels. These changes were only partly corrected after transplantation. Conclusion: Bone health in cystinosis deteriorates with age, which is associated with increased osteoclast activity despite counter-regulation of osteoblasts via OPG/RANKL, which in conjunction with elevated sclerostin levels and persistent rickets/osteomalacia, may promote progressive bone loss.
DOI: 10.5281/zenodo.17662220
title: Fotografías (IF)

description: Incluye este dataset una selección de las fotografías realizadas por los investigadores del proyecto de investigación Prácticas artísticas participativas para la apropiación del espacio público y el desarrollo de la calidad de vida urbana (FACTIBLES), durante las sesiones de trabajo de campo de los diferentes casos analizados en el proyecto. 

La finalidad del dataset es, por tanto, la recopilación de una selección de las distintas intervenciones artísticas analizadas en el proyecto fruto de las sesiones de trabajo de campo desarrolladas por el equipo de investigación del proyecto. Por tanto, los archivos ofrecen un catálogo de imágenes de los casos de estudio analizados en el proyecto de investigación. Todos los datos se ofrecen en formato imagen, con extensión JEPG. Todos los archivos se han generado ex novo a partir del propio proyecto. El origen de los datos es exclusivamente de elaboración propia de los integrantes del equipo de investigación y de trabajo del proyecto FACTIBLES. Los datos recopilados en este dataset son de utilidad para las personas que quieran conocer en detalle los casos de estudio analizados en su dimensión gráfica.
DOI: 10.5281/zenodo.17662221
title: Fotografías (IF)

description: Incluye este dataset una selección de las fotografías realizadas por los investigadores del proyecto de investigación Prácticas artísticas participativas para la apropiación del espacio público y el desarrollo de la calidad de vida urbana (FACTIBLES), durante las sesiones de trabajo de campo de los diferentes casos analizados en el proyecto. 

La finalidad del dataset es, por tanto, la recopilación de una selección de las distintas intervenciones artísticas analizadas en el proyecto fruto de las sesiones de trabajo de campo desarrolladas por el equipo de investigación del proyecto. Por tanto, los archivos ofrecen un catálogo de imágenes de los casos de estudio analizados en el proyecto de investigación. Todos los datos se ofrecen en formato imagen, con extensión JEPG. Todos los archivos se han generado ex novo a partir del propio proyecto. El origen de los datos es exclusivamente de elaboración propia de los integrantes del equipo de investigación y de trabajo del proyecto FACTIBLES. Los datos recopilados en este dataset son de utilidad para las personas que quieran conocer en detalle los casos de estudio analizados en su dimensión gráfica.
DOI: 10.34740/kaggle/dsv/13806037
title: PMRAM: Bangladeshi Brain Cancer Colorized MRI Data
DOI: 10.26068/mhhrpm/20241106-000
title: Participant recruiting for focus groups in health research: a meta-research study

description: Background: Focus groups (FGs) are an established method in health research to capture the different perspectives on a particular research question. The extent to which they are effective depends, not least, on the composition of the participants. This study aimed to investigate how published FG studies plan and conduct the recruitment of study participants. We looked at which kind of information are reported about recruitment and what this says about the actual recruitment plans and practices in terms of its quality. Data collection: We conducted a systematic search of FG studies in PubMed and Web of Science (January 2022 and October 2024) published between 2018-2024 and randomly selected half of the 153 eligible publications. We used an MS-Excel based text extraction sheet to collect all relevant recruitment information from each study. This included bibliographic information (first author, year, journal, country), information on the recruitment process (how was the recruiting done, by whom, when, with what aim, etc.) and information on the reporting and quality assurance (experience of the researchers who recruited FG participants, use of guidance, patient-public involvement, use of reporting checklists, informed consent, CoI). The data were extracted from the full texts of each included study and analysed by three authors (Cosima John, Simon Wallraf, Jonas Lander). We then coded the extracted text passages using key words and summarised the findings descriptively.
DOI: 10.26068/mhhrpm/20241108-000
title: New translational mouse models for metabolic dysfunction-associated steatotic liver disease comparable to human MASLD with severe obesity

description: Objective: Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common cause of chronic liver disease, in particular in patient with severe obesity. However, common mouse models for MASLD do neither represent a polygenetic background nor the metabolic changes in this population. Therefore, we investigated two new mouse models for MASLD with the polygenetic background for the metabolic syndrome. Methods: TALLYHO/JngJ mice and NONcNZO10/LtJ mice received a high-fat- high-carbohydrate (HF-HC) diet with a surplus of cholesterol diet. Results: After sixteen weeks of diet, both strains developed pronounced metabolic syndrome with severe obesity and histological manifestation of steatohepatitis. Subsequently, histological onset of MASH was associated with significantly increased intrahepatic CD8+cells, CD4+cells and Tregs, contributing to significant increase of pro-inflammatory and pro-fibrotic gene activation as well as ER stress and oxidative stress. Comparing with human transcriptomic signature, we could proof a good metabolic resemblance in particular for TH mouse model. Moreover, TH mice also developed sings of kidney injury as an extrahepatic comorbidity of MASLD. Conclusion: Overall, we developed two promising new mouse models, which are suitable for preclinical investigations of MASLD as they recapitulate most important hallmarks of MASLD.
DOI: 10.26068/mhhrpm/20241126-000
title: Transcription factor Tfap2a orchestrates a gene regulatory network mediating renal collecting duct cell differentiation and tubular architecture

description: These are primary data used for creating the figures of Leiz J, et al. 2024 (manuscript under revision). Transcription factor Tfap2a orchestrates a gene regulatory network mediating renal collecting duct cell differentiation and tubular architecture. Background: Mutations of the transcription factor TFAP2A are associated with congenital anomalies of the kidney and urinary tract in humans. Tfap2a knockout in mouse collecting ducts causes tubular epithelial abnormalities, but the detailed molecular functions of Tfap2a in the kidney tubules are unknown. Methods: We investigated gene regulatory networks regulated by Tfap2a in mouse kidney collecting ducts through a combination of gene knockout and transcriptomics approaches. Conditional Tfap2a knockout (KO) mice (Hoxb7-Cre; Tfap2aflox/flox) underwent detailed histomorphological and physiological examinations. Single-nucleus and bulk RNA-sequencing data, and in situ hybridizations of adult Tfap2a KO mouse kidneys were integrated with in silico Tfap2a motif mapping in existing ATAC-seq datasets. Results: Tfap2a expression and its motif activity were high in normal mouse collecting duct principal cells according to integrated transcriptomics, chromatin occupancy analyses, and in situ hybridization. Histomorphological analyses of collecting duct-specific Tfap2a KO mice indicated a progressive postnatal tubular dilation of outer medullary collecting ducts. Integrative analyses combining existing ATAC-seq datasets with newly generated single-nucleus RNA-sequencing data from the kidneys of 3-month-old Tfap2a KO mice and littermate controls identified deregulated expression of genes involved in cell adhesion and WNT signaling pathways, including Alcam (a cell adhesion molecule) and Wnt9b (a non-canonical WNT). These findings were orthogonally validated by in situ hybridization. Conclusions: Tfap2a controls tubular diameter and epithelial differentiation in mouse collecting ducts by controlling a regulatory network that includes Wnt9b and Alcam.
DOI: 10.3929/ethz-b-000668456
title: Magma chamber longevity on Mars and its controls on crustal structure and composition
DOI: 10.3929/ethz-b-000690084
title: The EuRoC micro aerial vehicle datasets
DOI: 10.26068/mhhrpm/20250204-000
title: Emotion Recognition and Gaze Behavior in Late-Diagnosed Adults with Autism Spectrum Disorder: A Comprehensive Eye-Tracking Study

description: This study examined emotion recognition ability and gaze patterns in adults with late-diagnosed autism spectrum disorder (ASD, n = 38) without intellectual or language impairment using an eye-tracking paradigm combined with a test of emotional stimuli (EU-Emotion Stimulus Set) and compared them to a sex-, age-, and intelligence quotient-matched non-autistic control group (NC, n = 33). File format: .sav; abbreviations and units in file.
DOI: 10.26068/mhhrpm/20250210-000
title: Nicotinamide Nucleotide Transhydrogenase deficiency and genetic susceptibility to high glucose-mediated peritoneal injury

description: The genetic predisposition to high glucose-induced injury to the peritoneal membrane (PM) during peritoneal dialysis (PD) and its mechanistic implications are of substantial clinical interest. We compared PD-induced peritoneal injury and fibrosis between two closely related mouse substrains. Compared to C57BL/6J mice, C57BL/6N mice exhibited significantly greater susceptibility to PD fluid-induced peritoneal damage, as indicated by the loss of the mesothelial cell monolayer, peritoneal membrane fibrosis, neoangiogenesis, inflammatory response, infiltration of pro-inflammatory M1 macrophages, and reduced ultrafiltration capacity. Given that C57BL/6J mice display a spontaneous loss-of-function mutation in the mitochondrial enzyme nicotinamide nucleotide transhydrogenase (NNT), which plays a critical role in maintaining mitochondrial redox balance and energy metabolism- both of which are severely challenged during PD- we conducted further NNT silencing experiments. Knockdown of NNT prevented the mitochondrial accumulation of reactive oxygen species (ROS), reduced pro-inflammatory mediator release in mouse peritoneal mesothelial cells, prevented M1 macrophage polarization in peritoneal macrophages, and strongly decreased proliferation under high glucose conditions in NIH-3T3 fibroblasts. We observed a reverse NNT reaction in fibroblasts, contributing to high glucose (HG)-induced mitochondrial reactive oxygen species (ROS) accumulation. Our results indicate decreased genetic susceptibility of C57BL/6J mice to PD-induced PM damage compared to C57BL/6N mice. Additionally, our in vitro experiments identify NNT, which is deficient in C57BL/6J mice, as a potential therapeutic target for PD-associated peritoneal injury.
DOI: 10.5517/ccdc.csd.cc2hks62
title: CCDC 2310994: Experimental Crystal Structure Determination

description: Related Article: Abdelhak Lachguar, Iker Del Rosal, Laurent Maron, Erwann Jeanneau, Laurent Veyre, Chloé Thieuleux, Clément Camp|2024|J.Am.Chem.Soc.|146|18306|doi:10.1021/jacs.4c02172
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2hks73
title: CCDC 2310995: Experimental Crystal Structure Determination

description: Related Article: Abdelhak Lachguar, Iker Del Rosal, Laurent Maron, Erwann Jeanneau, Laurent Veyre, Chloé Thieuleux, Clément Camp|2024|J.Am.Chem.Soc.|146|18306|doi:10.1021/jacs.4c02172
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2hksb6
title: CCDC 2310998: Experimental Crystal Structure Determination

description: Related Article: Abdelhak Lachguar, Iker Del Rosal, Laurent Maron, Erwann Jeanneau, Laurent Veyre, Chloé Thieuleux, Clément Camp|2024|J.Am.Chem.Soc.|146|18306|doi:10.1021/jacs.4c02172
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2hks95
title: CCDC 2310997: Experimental Crystal Structure Determination

description: Related Article: Abdelhak Lachguar, Iker Del Rosal, Laurent Maron, Erwann Jeanneau, Laurent Veyre, Chloé Thieuleux, Clément Camp|2024|J.Am.Chem.Soc.|146|18306|doi:10.1021/jacs.4c02172
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2hksc7
title: CCDC 2310999: Experimental Crystal Structure Determination

description: Related Article: Abdelhak Lachguar, Iker Del Rosal, Laurent Maron, Erwann Jeanneau, Laurent Veyre, Chloé Thieuleux, Clément Camp|2024|J.Am.Chem.Soc.|146|18306|doi:10.1021/jacs.4c02172
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.26068/mhhrpm/20250331-000
title: Comparison of accumulation and distribution of PEGylated and CD-47-functionalized magnetic nanoporous silica nanoparticles in an in vivo mouse model of implant infection

description: Die zur Verfügung gestellten Rohdaten sind im Rahmen einer tierexperimentellen Studie erhoben (Genehmigungsnummer beim LAVES Nds.: 33.19-42502-04-20/3394) Es handelt sich um histologische Scorewerte, die nach dem im SI des Manuskripts verwendeten Score erhoben wurden und im Excel-Format zur Verfügung gestellt werden. Weiterhin werden mikroskopisch erhobene Messdaten zur Oberflächenanalyse der Implantate im Hinblick auf Partikelanreicherung (Messung der Fluoreszenzsignale in prozentualem Anteil der Gesamtimplantatfläche) ebenfalls im Excel-Format zur Verfügung gestellt. Die Daten wurden im Q3 2023 an der Medizinischen Hochschule Hannover (NIFE) erhoben.
DOI: 10.5517/ccdc.csd.cc2hks84
title: CCDC 2310996: Experimental Crystal Structure Determination

description: Related Article: Abdelhak Lachguar, Iker Del Rosal, Laurent Maron, Erwann Jeanneau, Laurent Veyre, Chloé Thieuleux, Clément Camp|2024|J.Am.Chem.Soc.|146|18306|doi:10.1021/jacs.4c02172
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.26068/mhhrpm/20250331-001
title: Focused attention in late-diagnosed adults with autism spectrum disorder - a matter of reaction time?

description: This study examined focused attentional profiles in adults with late-diagnosed autism spectrum disorder without intellectual disability and compared them to a matched non-autistic control group (NC) using the Test Battery for Attention Performance (TAP). The study included 37 individuals with ASD and 34 NC. File format: .sav; abbreviations and units in file.
DOI: 10.15468/dl.ptrab9
title: Occurrence Download

description: A dataset containing 524 species occurrences available in GBIF matching the query:
{
 "and" : [
 "BasisOfRecord is Human Observation",
 "Country is Canada",
 "Geometry POLYGON((-74.03471 45.37555,-74.0692 45.35485,-73.98183 45.29967,-73.86687 45.28358,-73.61856 45.29277,-73.45762 45.31807,-73.31507 45.39854,-73.30587 45.58247,-73.34726 45.73192,-73.5059 45.75491,-73.7979 45.75261,-74.03471 45.59627,-74.08299 45.46751,-74.03471 45.37555))",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 "TaxonKey is Vulpes vulpes"
 ]
}

 The dataset includes 524 records from 3 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0000699-251120083545085/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.26068/mhhrpm/20250530-000
title: Ilf2 is a regulator of stress resilience and plasticity in kidney epithelial cells

description: The submitted research data consist of two main components: (1) processed RNA sequencing datasets (including bulk RNA-Seq, and single-cell RNA-Seq) derived from mouse kidney, and (2) microscopy images from accompanying cellular experiments such as immunofluorescence staining.RNA sequencing was performed using a [Illumina NovaSeq 6000] platform. The data were processed using standard bioinformatics tools such as [STAR, DESeq2, Seurat], and include normalized expression values (TPM and normalized counts). Microscopy images were acquired using a confocal microscope. Data collection and analysis were conducted between October 2023 and March 2025 at the Institute of Nephrology, Hannover Medical School (MHH). A complete list of references is included in the associated manuscript and can be checked after publishing.
DOI: 10.26068/mhhrpm/20250613-000
title: Data CTE project.xlsx

description: Data concerning the following project/manuscript: Rodrigo Moraga-Amaro, Oscar Moreno, Jordi Llop, Marion Bankstahl, Jens P. Bankstahl Biomarkers for prediction of chronic traumatic encephalopathy-like pathology following repeated mild traumatic brain injury in rats are sex- and age-dependent Introduction. Repeated mild traumatic brain injuries (rmTBI) pose a high risk for developing chronic traumatic encephalopathy (CTE). Since this neurodegenerative disease is diagnosed only post-mortem, new biomarkers for early detection are needed. Although age at injury and biological sex are important factors in many brain pathologies, little is known about their relevance for rmTBI-induced CTE-like consequences. Hence, this study explored how biological sex and age at time of impact affect progression and changes in biomarker candidates after experimental rmTBI. Methods. Rats of both sexes, aged 7-weeks (adolescent) or 14-weeks (adult), were subjected to three mTBI at 5-day intervals. Neurological, behavioural and cognitive impairments, as well as changes in potential plasma and brain biomarkers, were assessed up to 12-weeks post-injury. The generalized estimating equation model was used to compare sexes and age groups. Results. RmTBI induced ongoing neurological impairment. While no depressive-like behaviour was observed, long-term, age-specific changes in anxiety were observed after rmTBI. A short-term increase in plasma p-tau was found after rmTBI only in male and adolescent rats. Plasma neuron-specific enolase (NSE) levels were elevated in adolescent animals at both 2-weeks and 12-weeks post-rmTBI. An increase in brain neurofibrillary tangles (NFT) was detected 12-weeks after rmTBI. Correlation analyses suggested NSE as a prospective biomarker for anhedonia-like behaviour, and brain NFT as an indicator of neurological impairment. Discussion. We found that behavioural outcomes and biomarker changes following rmTBI in rats were both age- and sex-dependent. This information will help to develop translatable diagnostics to guide CTE treatment in clinical settings. Data were acquired at MHH by Rodrigo Moraga-Amaro et al.
DOI: 10.15468/dl.34g6yz
title: Occurrence Download

description: A dataset containing 5782 species occurrences available in GBIF matching the query:
{
 "and" : [
 "OccurrenceStatus is Present",
 "TaxonKey is Parnara guttatus"
 ]
}

 The dataset includes 5782 records from 93 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0000700-251120083545085/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.nspnrw
title: Occurrence Download

description: A dataset containing 34 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Month is one of (October, November)",
 "TaxonKey is Pseudorhiza haeckeli",
 "Year 2025-2025"
 ]
}

 The dataset includes 34 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0000702-251120083545085/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.2zmykp
title: Occurrence Download

description: A dataset containing 6861 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Aptenopedes"
 ]
}

 The dataset includes 6861 records from 20 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0000701-251120083545085/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.