cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.7102925.v1
title: The effects of riboflavin and ultraviolet light on keratocytes cultured in vitro

description: ABSTRACT Purpose: To culture quiescent human keratocytes and evaluate the effects of ultraviolet light and riboflavin on human corneal keratocytes in vitro. Methods: Keratocytes were obtained from remaining corneoscleral ring donor corneas previously used in corneal transplant surgeries and cultured in DMEM/F12 with 2% FBS until confluence. Characterization of cultured cells was performed by immunofluorescence analysis for anti-cytokeratin-3, anti-Thy-1, anti-α-smooth muscle actin, and anti-lumican. Immunofluorescence was performed before and after treatment of cultured cells with either ultraviolet light or riboflavin. Corneal stromal cells were covered with collagen (200 µL or 500 µL) and 0.1% riboflavin, and then exposed to ultraviolet light at 370 nm for 30 minutes. After 24 hours, cytotoxicity was determined using MTT colorimetric assays, whereas cell viability was assessed using Hoechst 33342 and propidium iodide. Results: Cell cultures achieved confluence in approximately 20 days. Expression of the lumican was high, whereas no expression of CK3, Thy-1, and α-SMA was observed. After crosslinking, MTT colorimetric assays demonstrated a low toxicity rate, whereas Hoechst 33342/propidium iodide staining demonstrated a low rate of apoptosis and necrosis, respectively, in all collagen-treatment groups. Conclusion: Keratocytes can be successfully cultured in vitro and characterized by immunofluorescence using lumican. MTT colorimetric assays, and Hoechst 33342, and propidium iodide staining demonstrated a higher rate of cell death in cells cultured without collagen, indicating collagen protects keratocytes from the cytotoxic effects of ultraviolet light.
DOI: 10.6084/m9.figshare.7102928.v1
title: Sequences of Primitive and Non-primitive BCH Codes

description: ABSTRACT In this work, we introduce a method by which it is established that how a sequence of non-primitive BCH codes can be obtained by a given primitive BCH code. For this, we rush to the out of routine assembling technique of BCH codes and use the structure of monoid rings instead of polynomial rings. Accordingly, it is gotten that there is a sequence { C b j n } 1 ≤ j ≤ m, where b j n is the length of C b j n, of non-primitive binary BCH codes against a given binary BCH code C n of length n. Matlab based simulated algorithms for encoding and decoding for these type of codes are introduced. Matlab provides in routines for construction of a primitive BCH code, but impose several constraints, like degree s of primitive irreducible polynomial should be less than 16. This work focuses on non-primitive irreducible polynomials having degree bs, which go far more than 16.
DOI: 10.6084/m9.figshare.7102919
title: Rothmund-Thomson syndrome and ocular surface findings: case reports and review of the literature

description: ABSTRACT Rothmund-Thomson syndrome (RTS) is a rare dermatosis with about 300 cases reported to date. The authors describe two siblings with RTS and inflammatory conjunctival disease featuring fornix shortening and symblepharon as well as palpebral disease with sparse eyelashes. These cases demonstrate RTS ocular surface findings different to those usually described.
DOI: 10.6084/m9.figshare.7102919.v1
title: Rothmund-Thomson syndrome and ocular surface findings: case reports and review of the literature

description: ABSTRACT Rothmund-Thomson syndrome (RTS) is a rare dermatosis with about 300 cases reported to date. The authors describe two siblings with RTS and inflammatory conjunctival disease featuring fornix shortening and symblepharon as well as palpebral disease with sparse eyelashes. These cases demonstrate RTS ocular surface findings different to those usually described.
DOI: 10.6084/m9.figshare.7102922
title: Efficacy of aflibercept on exudative age-related macular degeneration in patients exhibiting complete ranibizumab resistance and tachyphylaxis

description: ABSTRACT Purpose: The present study compared the efficacy of aflibercept for neovascular age-related macular degeneration (NV-AMD) in patients with complete ranibizumab resistance and tachyphylaxis. Methods: Forty-four eyes of 38 neovascular age-related macular degeneration patients were evaluated. Eyes were divided into a complete resistance group (n=23 eyes) and tachyphylaxis group (n=21 eyes). Results: After three injections, eight (38.1%) patients in the tachyphylaxis group and nine (39.1%) in the complete resistance group presented with macular dryness. After the first injection of aflibercept, the mean visual acuity improved significantly in the tachyphylaxis group (p=0.018) but remained unchanged in the complete resistance group (p=0.37). There was a non-significant trend towards improved mean visual acuity in both groups after the second and third injections relative to the acuity at the final visit for ranibizumab treatment. In the tachyphylaxis group, the presence of subfoveal pigmented epithelium detachment (PED) decreased significantly after intravitreal aflibercept treatment. Conclusions: Although treatment with aflibercept yielded generally positive anatomical results in both groups, no significant increase in visual acuity was achieved.
DOI: 10.6084/m9.figshare.7102922.v1
title: Efficacy of aflibercept on exudative age-related macular degeneration in patients exhibiting complete ranibizumab resistance and tachyphylaxis

description: ABSTRACT Purpose: The present study compared the efficacy of aflibercept for neovascular age-related macular degeneration (NV-AMD) in patients with complete ranibizumab resistance and tachyphylaxis. Methods: Forty-four eyes of 38 neovascular age-related macular degeneration patients were evaluated. Eyes were divided into a complete resistance group (n=23 eyes) and tachyphylaxis group (n=21 eyes). Results: After three injections, eight (38.1%) patients in the tachyphylaxis group and nine (39.1%) in the complete resistance group presented with macular dryness. After the first injection of aflibercept, the mean visual acuity improved significantly in the tachyphylaxis group (p=0.018) but remained unchanged in the complete resistance group (p=0.37). There was a non-significant trend towards improved mean visual acuity in both groups after the second and third injections relative to the acuity at the final visit for ranibizumab treatment. In the tachyphylaxis group, the presence of subfoveal pigmented epithelium detachment (PED) decreased significantly after intravitreal aflibercept treatment. Conclusions: Although treatment with aflibercept yielded generally positive anatomical results in both groups, no significant increase in visual acuity was achieved.
DOI: 10.6084/m9.figshare.7102913
title: Systematic review of childhood and adolescence sedentary behavior: analysis of the Report Card Brazil 2018

description: Abstract The aim of this study was to summarize studies examining the prevalence of sedentary behavior among Brazilian children and adolescents. A systematic review conducted on eight databases (PubMed, Scopus, Web of Science, LILACS, SPORTDiscus, BIREME, Scielo, and Google Scholar). The criteria applied were: original research; samples including Brazilian children and adolescents; to be a school- or population-based survey; observational studies using different measures of sedentary behavior; studies showing the prevalence of at least one component of sedentary behavior. Of the 205 studies included, 104 were analyzed. There was a greater concentration of studies in the southern (n=41) and northeastern (n=18) regions. The components more frequently investigated were watching TV (n=36) and screen time (n=32). Only three studies included children under seven years, and the age range more investigated was 10 to 19 years. Most of the studies used a self-reported questionnaire and showed variability in the cut-off point applied (from 2 to 4 hours/day). The prevalence of adolescents who met recommendations ranged from 9.4% to 68.0% for sedentary behavior (&lt;2 hours/day) and from 16.8% to 67.2% for TV viewing (&lt;2 hours/day). The prevalence ranged from 39.1% to 97.7% for computer use and from 47.7% to 98.0% for videogame use. Most of the studies reported that less than half of the adolescents met the recommendations of sedentary behavior and TV viewing. On the other hand, more than half of them devoted less than two hours a day to computer and videogame use.
DOI: 10.6084/m9.figshare.7102916
title: Effect of corneal biomechanical properties on surgically-induced astigmatism and higher-order aberrations after cataract surgery

description: ABSTRACT Purpose: To investigate the relationship between biomechanical properties of the cornea and postoperative refractive changes in patients with low-level astigmatism after cataract surgery. Methods: This prospective study recruited patients undergoing cataract surgery involving 2.8-mm superior incisions. Biomechanical properties of the cornea were evaluated preoperatively using the Ocular Response Analyzer, and corneal profiles were evaluated using a Scheimpflug system (Pentacam HR). Topographic astigmatism, total corneal aberrations (TCA) and higher-order corneal aberrations (HOCA) analyses were performed preoperatively and during 1- and 3-month postoperative exams. The incidences of surgically-induced astigmatism (SIA) and HOCAs were calculated using vector analyses. Associations of the preoperative biomechanical properties of the cornea with SIA and HOCAs were evaluated. Results: This study included 28 eyes of 28 patients. The preoperative corneal hysteresis (CH) was 8.68 ± 1.86 mmHg, and the corneal resistance factor (CRF) was 8.66 ± 1.61 mmHg. At the 1-month postoperative evaluation, significant changes were observed in HOCAs (p=0.023), TCAs (p=0.05), astigmatism (p=0.02), and trefoil (p=0.033); in contrast, differences in coma (p=0.386) and spherical aberration (SA) were not significant (p=0.947). At the 3-month visit, significant changes were only observed in TCAs (p=0.02) and HOCAs (p=0.012). No relationships between the preoperative corneal hysteresis and corneal resistance factor and postoperative SIA and HOCA were identified, other than a positive correlation between the 3-month postoperative incidence of corneal hysteresis and spherical aberration. Conclusions: Despite the observed lack of relationships of preoperative biomechanical properties of the cornea with SIA and postoperative aberrations (except for SA), further studies involving larger patient groups are needed to explore the unexpected refractive deviations after cataract surgery.
DOI: 10.6084/m9.figshare.7102916.v1
title: Effect of corneal biomechanical properties on surgically-induced astigmatism and higher-order aberrations after cataract surgery

description: ABSTRACT Purpose: To investigate the relationship between biomechanical properties of the cornea and postoperative refractive changes in patients with low-level astigmatism after cataract surgery. Methods: This prospective study recruited patients undergoing cataract surgery involving 2.8-mm superior incisions. Biomechanical properties of the cornea were evaluated preoperatively using the Ocular Response Analyzer, and corneal profiles were evaluated using a Scheimpflug system (Pentacam HR). Topographic astigmatism, total corneal aberrations (TCA) and higher-order corneal aberrations (HOCA) analyses were performed preoperatively and during 1- and 3-month postoperative exams. The incidences of surgically-induced astigmatism (SIA) and HOCAs were calculated using vector analyses. Associations of the preoperative biomechanical properties of the cornea with SIA and HOCAs were evaluated. Results: This study included 28 eyes of 28 patients. The preoperative corneal hysteresis (CH) was 8.68 ± 1.86 mmHg, and the corneal resistance factor (CRF) was 8.66 ± 1.61 mmHg. At the 1-month postoperative evaluation, significant changes were observed in HOCAs (p=0.023), TCAs (p=0.05), astigmatism (p=0.02), and trefoil (p=0.033); in contrast, differences in coma (p=0.386) and spherical aberration (SA) were not significant (p=0.947). At the 3-month visit, significant changes were only observed in TCAs (p=0.02) and HOCAs (p=0.012). No relationships between the preoperative corneal hysteresis and corneal resistance factor and postoperative SIA and HOCA were identified, other than a positive correlation between the 3-month postoperative incidence of corneal hysteresis and spherical aberration. Conclusions: Despite the observed lack of relationships of preoperative biomechanical properties of the cornea with SIA and postoperative aberrations (except for SA), further studies involving larger patient groups are needed to explore the unexpected refractive deviations after cataract surgery.
DOI: 10.6084/m9.figshare.7102913.v1
title: Systematic review of childhood and adolescence sedentary behavior: analysis of the Report Card Brazil 2018

description: Abstract The aim of this study was to summarize studies examining the prevalence of sedentary behavior among Brazilian children and adolescents. A systematic review conducted on eight databases (PubMed, Scopus, Web of Science, LILACS, SPORTDiscus, BIREME, Scielo, and Google Scholar). The criteria applied were: original research; samples including Brazilian children and adolescents; to be a school- or population-based survey; observational studies using different measures of sedentary behavior; studies showing the prevalence of at least one component of sedentary behavior. Of the 205 studies included, 104 were analyzed. There was a greater concentration of studies in the southern (n=41) and northeastern (n=18) regions. The components more frequently investigated were watching TV (n=36) and screen time (n=32). Only three studies included children under seven years, and the age range more investigated was 10 to 19 years. Most of the studies used a self-reported questionnaire and showed variability in the cut-off point applied (from 2 to 4 hours/day). The prevalence of adolescents who met recommendations ranged from 9.4% to 68.0% for sedentary behavior (&lt;2 hours/day) and from 16.8% to 67.2% for TV viewing (&lt;2 hours/day). The prevalence ranged from 39.1% to 97.7% for computer use and from 47.7% to 98.0% for videogame use. Most of the studies reported that less than half of the adolescents met the recommendations of sedentary behavior and TV viewing. On the other hand, more than half of them devoted less than two hours a day to computer and videogame use.
DOI: 10.5281/zenodo.3974444
title: Augmented emission maps: 1968 cc 55 Kw Euro 6 diesel engine: update 1

description: In order to enable the sharing of data the emission data for vehicles is standardized. The data exchange format contains all data that is applicable for a specific engine taxonomy code. This specific data set refers to the 1968 cc 55 kW Euro 6 diesel engine that has been applied in the Volkswagen Caddy. The standardized emission map has a “.map.txt” extension and is also human readable. The files starts with metadata which contains information about: the engine taxonomy code, total driven kilometers over which the data was gathered, total time in hours over which the data was gathered, the number of vehicles which were tested to create the emission map, the DOI (Digital Object Identifier) reference, Which emission maps are available in the file. The DOI 10.5281/zenodo refers to a meta-data document that provides the full description of the standardized emission map.
DOI: 10.6084/m9.figshare.7102892
title: ADVANTAGES AND WEAKNESSES OF PERCUTANEOUS ENDOSCOPIC LUMBAR DISCECTOMY: ALGORITHM SELECTION

description: ABSTRACT Objective: Degenerative diseases of the spine are the most common disorder seen in the practice of the neurosurgeon. According to many surgeons, microdiscectomy is the “gold standard” of surgical treatment. Analyzing the current literature, it is seen that the use of endoscopic techniques in spinal surgery is increasing. However, due to the lack of detailed information on the advantages and disadvantages of these methods, there is a need for continuing research in this area. Work to clarify the features of these methods, their specificity and algorithmization will increase the effectiveness of surgical treatment. Methods: This study included patients with herniated lumbar intervertebral discs, the presence of pain in the leg, and failed of conservative therapy. In the period 2014 to 2017, 172 endoscopic lumbar discectomies were performed, using microendoscopic discectomy and percutaneous endoscopic lumbar discectomy. The effectiveness of each technique was evaluated through comparative analysis. Results: In both groups, the methods used obtained high efficacy rates. Comparative analysis showed the advantages of the percutaneous technique in terms of shortening the return to normal activity time, hospitalization time, and disability, and reducing back pain in the early postoperative period. On the other hand, the microendoscopic discectomy enabled greater radicality to be achieved in cases with herniated disc ossification and complex anatomy of the vertebral segment. Conclusions: Analysis of the data obtained led to the formulation of an algorithm for selecting the optimum endoscopic method for achieving positive results of surgical treatment. Level of Evidence II; Therapeutic studies, investigating the results of treatment.
DOI: 10.6084/m9.figshare.7102886
title: Partnership for productive development of biosimilar products: perspectives of access to biological products in the Brazilian market

description: ABSTRACT The manufacturing process for biological products is complex, expensive and critical to the final product, with an impact on their efficacy and safety. They have been increasingly used to treat several diseases, and account for approximately 50% of the yearly budget for the Brazilian public health system. As the patents of biological products expire, several biosimilars are developed. However, there are concerns regarding their efficacy and safety; therefore, the regulatory agencies establish rules to approve and monitor these products. In Brazil, partnership programs between national government-owned companies and private technology holders have been implemented, aiming at knowledge sharing, capacity-building and technological transfer. Such partnerships locally promote manufacturing of these strategic drugs at reduced costs to the public health system. These agreements offer mutual advantages to both the government and patent holders: for the former, a biotechnological development flow is established and enables potential cost reduction and self-sufficient production; whereas for the latter, exclusive sales of the product are ensured during technological transfer, for a fixed period.
DOI: 10.6084/m9.figshare.7102886.v1
title: Partnership for productive development of biosimilar products: perspectives of access to biological products in the Brazilian market

description: ABSTRACT The manufacturing process for biological products is complex, expensive and critical to the final product, with an impact on their efficacy and safety. They have been increasingly used to treat several diseases, and account for approximately 50% of the yearly budget for the Brazilian public health system. As the patents of biological products expire, several biosimilars are developed. However, there are concerns regarding their efficacy and safety; therefore, the regulatory agencies establish rules to approve and monitor these products. In Brazil, partnership programs between national government-owned companies and private technology holders have been implemented, aiming at knowledge sharing, capacity-building and technological transfer. Such partnerships locally promote manufacturing of these strategic drugs at reduced costs to the public health system. These agreements offer mutual advantages to both the government and patent holders: for the former, a biotechnological development flow is established and enables potential cost reduction and self-sufficient production; whereas for the latter, exclusive sales of the product are ensured during technological transfer, for a fixed period.
DOI: 10.6084/m9.figshare.7102892.v1
title: ADVANTAGES AND WEAKNESSES OF PERCUTANEOUS ENDOSCOPIC LUMBAR DISCECTOMY: ALGORITHM SELECTION

description: ABSTRACT Objective: Degenerative diseases of the spine are the most common disorder seen in the practice of the neurosurgeon. According to many surgeons, microdiscectomy is the “gold standard” of surgical treatment. Analyzing the current literature, it is seen that the use of endoscopic techniques in spinal surgery is increasing. However, due to the lack of detailed information on the advantages and disadvantages of these methods, there is a need for continuing research in this area. Work to clarify the features of these methods, their specificity and algorithmization will increase the effectiveness of surgical treatment. Methods: This study included patients with herniated lumbar intervertebral discs, the presence of pain in the leg, and failed of conservative therapy. In the period 2014 to 2017, 172 endoscopic lumbar discectomies were performed, using microendoscopic discectomy and percutaneous endoscopic lumbar discectomy. The effectiveness of each technique was evaluated through comparative analysis. Results: In both groups, the methods used obtained high efficacy rates. Comparative analysis showed the advantages of the percutaneous technique in terms of shortening the return to normal activity time, hospitalization time, and disability, and reducing back pain in the early postoperative period. On the other hand, the microendoscopic discectomy enabled greater radicality to be achieved in cases with herniated disc ossification and complex anatomy of the vertebral segment. Conclusions: Analysis of the data obtained led to the formulation of an algorithm for selecting the optimum endoscopic method for achieving positive results of surgical treatment. Level of Evidence II; Therapeutic studies, investigating the results of treatment.
DOI: 10.6084/m9.figshare.7102880
title: ELBOW WRAP IMPROVES BENCH PRESS PERFORMANCE IN TRAINED SUBJECTS

description: ABSTRACT Introduction: The elastic wrap is widely used by different types of athletes and recreational practitioners of strength training in order to improve weightlifting performance. Objective: The objective was to investigate the acute effects of elbow wrap on strength performance, absolute volume, and rating of perceived exertion/discomfort during the bench press (BP) exercise. Methods: The experimental protocol was divided into three laboratory sessions. At the first session, a bench press familiarization phase was performed with (EW) and without (WEW) elastic elbow wrap. During the second session, the 1RM test was carried out in the bench press exercise under both EW and WEW conditions. At the third session, the repetition maximum (RM) test at 70% of 1RM (EW and WEW) was performed until concentric failure. After each session, subjects were consulted about their rate of perceived exertion (RPE), and discomfort (PSD). A paired student t-test was used to compare the values of 1RM and RMs with and without elastic wraps. Descriptive analysis was used for RPE and PSD. Results: For the 1RM test, there was a significant increase for the EW condition when compared to WEW (p&lt;0.05). In the RMs test and absolute volume calculation, there was a significant increase for the EW condition (p&lt;0.05). RPE did not differ in any of the conditions tested (p&gt;0.05). PSD presented a high degree of discomfort with elastic wraps in all conditions. Conclusion: Elastic elbow wraps increase the load lifted in the 1RM test, and the maximum number of repetitions during the BP exercise, and consequently, the absolute volume. The elastic elbow wrap does not alter the subjective perception of effort, but it increases discomfort during exercise.