cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.24494926.v1
title: Supplementary Material for: Bone Marrow Mesenchymal Stem Cells Release miR-378a-5p-Carried Extracellular Vesicles to Alleviate Rheumatoid Arthritis

description: This study investigates whether bone marrow mesenchymal stem cells (BMSCs)-derived extracellular vesicles (EVs) can affect rheumatoid arthritis (RA) by delivering microRNA (miR)-378a-5p to regulate the IRF1/STAT1 axis. We identified RA-associated miRNAs using GEO microarray dataset GSE121894. We found the most important miRNAs in RA synovial tissues using RT-qPCR. BMSCs-derived EVs were ultracentrifuged and co-cultured with HSMECs in vitro. Dual-luciferase and RIP studies examined miR-378a-5p's specific binding to IRF1. We also measured angiogenesis, migration, and proliferation using CCK-8, Transwell, and tube formation assays. CIA (collagen-induced arthritis) mice models were created by inducing arthritis and scoring it. RA synovial tissues had low miR-378a-5p expression, whereas BMSC-derived EVs had high levels. The transfer of miR-378a-5p by BMSC-derived EVs to HSMECs boosted proliferation, migration, and angiogenesis. miR-378a-5p inhibited IRF1. MiR-378a-5p-containing BMSC-derived EVs decreased STAT1 phosphorylation and HSMEC IRF1 expression. EVs with miR-378a-5p mimic promoted HSMEC proliferation, migration, and angiogenesis, whereas dexmedetomidine inhibited STAT1 phosphorylation. In CIA mice, BMSC-derived EVs containing miR-378a-5p enhanced synovial vascular remodeling and histopathology. Thus, miR-378a-5p from BMSC-derived EVs promotes HSMEC proliferation, migration, and angiogenesis, inactivating the IRF1/STAT1 axis and preventing rheumatoid arthritis.
DOI: 10.6084/m9.figshare.27715401.v1
title: Stock prediction

description: Stock data and forecast analysis results of some Chinese listed companies
DOI: 10.6084/m9.figshare.6838751.v1
title: Additional file 3 of Benchmarking differential expression analysis tools for RNA-Seq: normalization-based vs. log-ratio transformation-based methods

description: Estimated relative abundance for Rollins et al. data (by stsl method). This table contains the relative transcript abundances as estimated using the stsl procedure. (CSV 4579 kb)
DOI: 10.6084/m9.figshare.21299148.v1
title: Open Fundus Photograph Dataset with Pathologic Myopia Recognition and Anatomical Structure Annotation

description: This dataset contains 1200 color fundus images, which are a powerful resource to observe the fundus lesions, and build tools for automated diagnosis and analysis of pathologic myopia. In addition to color fundus images and labels for pathologic myopia category, our pathologic myopia (PALM) dataset also provides manual annotations of the optic disc and two lesion regions (atrophy and detachment), fovea localization, as well as data on the image acquisition procedure and device.
DOI: 10.6084/m9.figshare.5104684.v1
title: Supplementary Material for: Microtubule-Associated Protein 1B Interaction with Tubulin Tyrosine Ligase Contributes to the Control of Microtubule Tyrosination

description: Microtubule-associated protein 1B (MAP1B) is the first microtubule-associated protein to be expressed during nervous system development. MAP1B belongs to a large family of proteins that contribute to the stabilization and/or enhancement of microtubule polymerization. These functions are related to the control of the dynamic properties of microtubules. The C-terminal domain of the neuronal α-tubulin isotype is characterized by the presence of an acidic polypeptide, with the last amino acid being tyrosine. This tyrosine residue may be enzymatically removed from the protein by an unknown carboxypeptidase activity. Subsequently, the tyrosine residue is again incorporated into this tubulinby another enzyme, tubulin tyrosine ligase, to yield tyrosinated tubulin. Because neurons lacking MAP1B have a reduced proportion of tyrosinated microtubules, we analyzed the possible interaction between MAP1B and tubulin tyrosine ligase. Our results show that these proteins indeed interact and that the interaction is not affected by MAP1B phosphorylation. Additionally, neurons lacking MAP1B, when exposed to drugs that reversibly depolymerize microtubules, do not fully recover tyrosinated microtubules upon drug removal. These results suggest that MAP1B regulates tyrosination of α-tubulin in neuronal microtubules. This regulation may be important for general processes involved in nervous system development such as axonal guidance and neuronal migration.
DOI: 10.6084/m9.figshare.14725179.v1
title: Compressed sequence alignments

description: There are four files contained in this compressed folder1) sequence alignment used to generate the species-level dated phylogeny (Figure 1, Roycroft_species_level.phy)2) sequence alignment used to generate intraspecies phylogeny (Figure S1, Roycroft_intraspecies.fasta)3) whole exome alignments from 48 species, used to estimate heterozygosity (Roycroft_whole_exome_48.fasta)4) sequence alignment of samples used to generate IBD plot (Figure S2, Roycroft_hermanns_gouldii_IBD.nex)
DOI: 10.6084/m9.figshare.19196537.v1
title: covid spss 20.sav

description: This is covid-19 questionnaire data<br>
DOI: 10.6084/m9.figshare.23936262.v3
title: Biomass Calculations (Excel)

description: This file provides the input data, assumptions and calculations used to compute the statistics on forest area, biomass, FAWS and BAWS for Europe, harmonized for definitions and reference year.The description of the content of this file is provided in the "ReadMe" spreadsheet within the file
DOI: 10.6084/m9.figshare.25997302.v1
title: Trainees' perspectives on residency training programs in anesthesiology, intensive care and emergency medicine

description: Residency programs in anesthesiology and intensive care (AIC), and emergency medicine (EM) continually evolve to ensure well-prepared trainees for these critical fields of healthcare. The objective of this study was to collect comprehensive feed-back from AIC and EM residents, comprising opinions and attitudes on: curriculum and structure of the residency program; scope of training environment, opportunities and complexity; training guidance and mentorship; teaching approach. An anonymous online cross-sectional survey was conducted among AIC and EM trainees during December 2023 – January 2024 and June 2023 – July 2023, respectively.
DOI: 10.6084/m9.figshare.12579197.v2
title: Raw data from "Higher socioeconomic status predicts less adolescent depression".sav

description: Participants were 652 adolescents (age range: 11-20 years old, <i>M</i><sub>age</sub> =14.55 years, <i>SD</i> = 1.82; 338 boys (51.80%)) from two junior and two senior high schools in Wuhan, China. They completed questionnaires measuring family socioeconomic status (measured by the Family Affluence Scale), perceived social support (measured by the Multidimensional Scale of Perceived Social Support) , optimism (assessed by the Chinese version of the Life Orientation Test-Revised), and depression (measured by the Center for Epidemiologic Studies Depression Scale). Our research plan, questionnaires and the appropriate consent letters to students and their parents were submitted to the university’s Ethical Committee for Scientific Research, then examined by specialists and finally approved by the Ethical Committee. After obtaining the approval, we visited the selected school principals, handed out copies of questionnaires and consent letters, and asked for their cooperation. Then classroom teachers sent electronic consent letters to parents about the purpose of the research, the importance of the adolescents’ involvement and the voluntary nature of participation by the online Family-School Communication System and asked for parents’ support and permission. Students took home the printed consent letters that had to be signed by the students’ guardians. Classroom teachers also distributed printed consent forms to students and asked for their participation. Students with parental consent who also assented to participate were allowed to take part in the survey. A packet of self-report questionnaires was administered to students in groups of 40-50 at a time in those selected classes. Trained graduate students of psychology explained the requirements of the questionnaires using standard instructions that also stressed the anonymity of students’ identities in the survey. The average time students spent to complete the survey was approximately 15 minutes.<br>
DOI: 10.6084/m9.figshare.20026948.v1
title: Active and passive solar energy integration in single-family dwelling roofs of real estate developments

description: Abstract This study analyses the possibility of achieving negative energy demands in single-family housing (Plus-Energy House). Through the integration of energy efficiency measures jointly with active solar systems, it is possible to obtain high performance energy models. In order to demonstrate this, we performed energy simulations integrating active solar systems, and also possible self-shading and separations between dwellings. We analysed the deployment of BIPV, BISTw, BIPVTa and BIPVTw technologies individually and in different combinations between them with the purpose of maximizing production capability for self-consumption, comparing them with residential demands in order to identify energy deficits and surpluses in different seasons. The measurements were taken hourly on typical days in summer, winter and intermediary seasons. Finally, an annual balance was obtained, showing energy surpluses of approximately 174 % when deploying only BIPV collectors and 251 % when combining BIPVTw and BIPVTa.
DOI: 10.6084/m9.figshare.28217000.v1
title: The Workplace Exploitation Scale (Wex-5) original data

description: This is the original dataset associated with the workplace exploitation scale (Wex-5) that has been published under the Creative Commons licence and can be found here along with the scoring: 10.6084/m9.figshare.28216910<br>For more information, contact the author, Dr. S. Rama Gokula Krishnan. Email: ramagokulakrishnan@gmail.com
DOI: 10.6084/m9.figshare.21707015.v3
title: Rawdata

description: fasta file of the assembled genomes and their relative abundnace.
DOI: 10.6084/m9.figshare.24173811.v1
title: data-ECS23-0332

description: The data describe the effect of grazing on the stability of community biomass
DOI: 10.6084/m9.figshare.24962391.v1
title: Datasets for: Valvular Prostaglandins are Elevated in Severe Human Aortic Valve Stenosis

description: Oxylipin analysis of aortic valves and plasma of aortic stenosis patients using HPLC-MS/MS.
DOI: 10.6084/m9.figshare.5124703.v1
title: Supplementary Material for: Polarity Index of Psychological Interventions in Maintenance Treatment of Bipolar Disorder

description: <b><i>Background:</i></b> Although several adjunctive psychological interventions are effective in the maintenance of bipolar disorders (BD), no attempt has been made to classify them according to their ability to prevent manic versus depressive episodes. Our study aims to rank the adjunctive psychotherapies for the prophylaxis of BD by means of their polarity index (PI). <b><i>Methods:</i></b> Randomized controlled trials comparing the efficacy of a psychological intervention with a comparator in BD maintenance treatment in patients aged over 18 were systematically reviewed. Exclusion criteria were a small sample size, a study sample not exclusively composed of bipolar patients and the absence of a control group. PI is a novel metric indicating the relative antimanic versus antidepressive preventive efficacy of treatments. PI was retrieved by calculating the ratio of the number needed to treat (NNT) for prevention of depression and the NNT for prevention of mania. PI &gt;1.0 indicates a relatively higher antimanic prophylactic efficacy and PI &lt;1.0 a greater antidepressive efficacy. <b><i>Results:</i></b> A total of 9 studies were included. PI was 0.33, 0.63 and 0.89 for cognitive-behavioral therapy, 0.42 for family-focused therapy, 0.73 and 0.78 for psychoeducation, 1 for enhanced relapse prevention, 1.78 for caregiver group psychoeducation and 3.36 for brief technique-driven interventions. With regard to the PI for 1 cognitive-behavioral study, enhanced relapse prevention and brief technique-driven interventions may not be reliable since those trials were negative. <b><i>Conclusions:</i></b> The PI provides a measure of how much depression-preventive or (hypo) mania-preventive an intervention is and may guide the choice of adjunctive psychotherapy in the context of individualized long-term treatment of BD.
DOI: 10.6084/m9.figshare.7775927.v1
title: Supplementary Material for: The Precuneus – A Witness for Excessive Aβ Gathering in Alzheimer’s Disease Pathology

description: Evidence of cortical beta-amyloid (Aβ) load, assessed by Aβ positron emission tomography (Aβ-PET), is an established in vivo biomarker of Alzheimer’s disease (AD)-related pathophysiology. Qualitative assessment of Aβ-PET provides binary information; meanwhile semiquantitative approaches require a parcellation of PET image either manually or by placement of atlas-based volumes of interest. We supposed that a whole-brain approach with voxel-by-voxel standardized uptake value ratio (SUVr) parametric images may better elucidate the spatial trajectories of Aβ burden along the continuum<i></i> of AD. <b><i>Methods:</i></b> We recruited 32 subjects with a diagnosis of probable AD dementia (ADD, <i>n</i> = 20) and mild cognitive impairment due to AD (MCI-AD, <i>n</i> = 12) according to the NIA-AA 2011 criteria. We also enrolled a control group of 6 cognitively healthy individuals (HCs) with preserved cognitive functions and negative Aβ-PET scan. The PET images were spatially normalized using the AV45 PET template in the MNI brain space. Subsequently, parametric SUVr images were calculated using the whole cerebellum as a reference region. A voxel-wise analysis of covariance was used to compare (between groups) the Αβ distribution pattern considering age as a nuisance covariate. <b><i>Results:</i></b> Both ADD and MCI-AD subjects showed a widespread increase in radiotracer uptake when compared with HC participants (<i>p</i> &lt; 0.001, uncorrected). After applying a multiple comparison correction (<i>p</i> &lt; 0.05, corrected), a relative large cluster of increased [<sup>18</sup>F]-flor­betapir uptake was observed in the precuneus in the ADD and MCI-AD groups compared to HCs. Voxel-wise regression analysis showed a significant positive linear association between the voxel-wise SUVr values and the disease duration. <b><i>Conclusions:</i></b> The voxel-wise semiquantitative analysis shows that the precuneus is a region with higher vulnerability to Aβ depositions when compared to other cortical regions in both MCI-AD and ADD subjects. We think that the precuneus is a promising PET-based outcome measure for clinical trials of drugs targeting brain Aβ. We found a positive association between the overall Aβ-PET SUVr and the disease duration suggesting that the region-specific slow saturation of Aβ deposition continuously takes place as the disease progresses.
DOI: 10.6084/m9.figshare.24618951.v1
title: Supplementary Material for: Clinical features, diagnosis, and treatment of congenital and neonatal tuberculosis: A retrospective study

description: Introduction: Limited studies have explored the clinical features, treatment and prognosis of neonatal tuberculosis (TB). Here, we attempted to delineate the clinical characteristics of neonatal TB, which may help clinicians further understand this disease. Methods: A retrospective analysis of neonates diagnosed with congenital and/or neonatal TB disease from January 2010 to December 2020 was performed. Information on the demographic and epidemiological features, clinical symptoms, laboratory and imaging examinations, therapeutic regimens, and outcomes was collected. Kaplan–Meier analysis was used to present the time to disease onset, time to diagnosis, etc.. Results: Forty-eight cases of neonatal TB were classified into congenital (n=33) and postnatal (n=15) . The median time to disease onset in postnatal group was significantly longer than that in congenital group. Positive results for gastric fluid acid-fast bacilli, TB culture, Xpert MTB/RIF, IGRA and TST were detected in 26/48 (54.2%), 14/34 (41.2%), 11/18 (61.1%), 19/29 (65.5%), and 8/24 (33.3%) patients, respectively. For lymphadenopathy, CT scans showed a higher detection rate than did X-ray (80.0% vs 0). Of the 48 infants, 44/48 (91.7%) received anti-TB therapy, and 33/44 (75%) were clinically improved or cured after 22.1 months (IQR 12.4–27.7) of follow-up. Drug-induced liver injury occurred in 14/44 (31.8%) patients. Discussion/Conclusion: IGRA and Xpert MTB/RIF showed good positive rate in neonatal TB infection/disease. In cases where TB is presumed but etiological evidence is lacking, low dose CT could be considered. Prompt treatment under careful surveillance is important for preventing mortality and avoiding severe adverse effects.
DOI: 10.6084/m9.figshare.6392078.v1
title: PHEME dataset for Rumour Detection and Veracity Classification

description: This dataset contains a collection of Twitter rumours and non-rumours posted during breaking news. <br> The data is structured as follows. Each event has a directory, with two subfolders, rumours and non-rumours. These two folders have folders named with a tweet ID. The tweet itself can be found on the 'source-tweet' directory of the tweet in question, and the directory 'reactions' has the set of tweets responding to that source tweet. Also each folder contains ‘annotation.json’ which contains information about veracity of the rumour and ‘structure.json’, which contains information about structure of the conversation. <br> This dataset is an extension of the PHEME dataset of rumours and non-rumours (https://figshare.com/articles/PHEME_dataset_of_rumours_and_non-rumours/4010619), it contains rumours related to 9 events and each of the rumours is annotated with its veracity value, either True, False or Unverified. <br> This dataset was used in the paper 'All-in-one: Multi-task Learning for Rumour Verification'. For more details, please refer to the paper. <br> Code using this dataset can be found on github (https://github.com/kochkinaelena/Multitask4Veracity). <br> License: The annotations are provided under a CC-BY license, while Twitter retains the ownership and rights of the content of the tweets.
DOI: 10.6084/m9.figshare.24441205.v1
title: Data set of anthropometric measurement , FMD, and exercise testing obtained from collegiate student athletes

description: The data include anthropometric measurement , FMD, and exercise testing obtained from collegiate student athletes.
DOI: 10.6084/m9.figshare.28152128.v1
title: Ventilation standards

description: This repository contains data files on ventilation rates and exposure risk assessment, as discussed in the comparison of IAQ standards (EN 16798-1:2019 and ASHRAE 62.1) and infection control documents (ASHRAE Standard 241, REHVA, WHO, and the Lancet COVID-19 Commission). The data includes analyses of ventilation design methods, exposure risk estimations, and infection risk metrics for classrooms, restaurants, and offices at various occupancy levels.
DOI: 10.6084/m9.figshare.13020695.v1
title: The effect of interannual precipitation variability on aboveground net primary production

description: Data synthesis and modeling results on the effect of interannual precipitation variability on aboveground net primary production in global drylands with mean annual precipitation less than 500 mm yr-1.<br>
DOI: 10.6084/m9.figshare.28558952.v1
title: Older Male Football Players Exhibit Significant Hamstring Strength Loss After a Match

description: Data
DOI: 10.6084/m9.figshare.5120608.v1
title: Supplementary Material for: Tube Is an IRAK-4 Homolog in a Toll Pathway Adapted for Development and Immunity

description: Acting through the Pelle and IRAK family of protein kinases, Toll receptors mediate innate immune responses in animals ranging from insects to humans. In flies, the Toll pathway also functions in patterning of the syncytial embryo and requires Tube, a <i>Drosophila</i>-specific adaptor protein lacking a catalytic domain. Here we provide evidence that the Tube, Pelle, and IRAK proteins originated from a common ancestral gene. Following gene duplication, IRAK-4, Tube-like kinases, and Tube diverged from IRAK-1, Pelle, and related kinases. Remarkably, the function of Tube and Pelle in <i>Drosophila</i> embryos can be reconstituted in a chimera modeled on the predicted progenitor gene. In addition, a divergent property of downstream transcription factors was correlated with developmental function. Together, these studies reveal previously unrecognized parallels in Toll signaling in fly and human innate immunity and shed light on the evolution of pathway organization and function.
DOI: 10.6084/m9.figshare.11589588.v1
title: TableS1-S5.xlsx

description: supplementary data for "Formation of the Yangyuan carbonatites, North China, by melting of limestone in the lower<br>continental crust <br>"
DOI: 10.6084/m9.figshare.16940683.v1
title: Dx5 dataset

description: Benchmark dataset and code associated with the article<br><br><i>A Dataset for Benchmarking Electron Density Representations and Data-Driven Density Functional Theory</i><br>The dataset contains molecular configurations of <b>Water</b>, <b>Water tetramer</b>, <b>ethane</b>, <b>butane</b>, <b>ethanol </b>taken from MD trajectories.<br><br>High-quality electronic structure data is provided in the form of <b>spin density matrices</b> (obtained from Hartree-Fock, LDA, PBE, PBE0 and PBE50 using the Psi4 code). Exact exchange energies for the total molecular densities are contained and provide the target for machine learning models. <br><br>For baseline machine learning models and density representations, the predictive accuracy is provided in the article. The dataset is suited to further improve machine-learned, non-local DFT approximations of exchange energy functionals.<br>
DOI: 10.6084/m9.figshare.26002402.v1
title: Supplementary Material for: Iron status, thyroid dysfunction and iron deficiency anemia: a two-sample Mendelian randomization study

description: Objective: Given the clinical association between thyroid dysfunction and iron deficiency anemia (IDA), as well as their shared association with iron status, this study aims to investigate the causal relationship between iron status and thyroid dysfunction, while also examining the risk of IDA in relation to thyroid dysfunction.
Methods: A two-sample Mendelian randomization (MR) study was conducted to identify the causal relationship of iron status on thyroid dysfunction, as well as thyroid dysfunction on IDA. Large-scale European population-based GWAS databases were utilized (Genetics of Iron Status consortium, ThyroidOmics consortium, FinnGen consortium, and UK biobank). Inverse variance weighted (IVW) was used as the main analysis. In addition, we used weighted median and MR-Egger to enhance the robustness. Sensitivity analysis was conducted to evaluate the robustness of MR results. 
Results: The IVW estimates did not reveal any significant causal relationship between serum iron status markers and thyroid dysfunction. However, a significant causal relationship was observed between hypothyroidism and IDA (OR = 1.101, 95% CI = 1.048-1.157, p &lt; 0.001). Repeated analyses also demonstrated a similar trend (OR = 1.023, 95% CI = 1.011-1.035, p &lt; 0.001). Sensitivity analysis supported that the MR estimates were robust.
Conclusion: In our MR study, an upregulation of the hypothyroidism-associated gene was found to be significantly associated with an elevated risk of IDA in the European population. These findings may offer novel therapeutic insights for clinicians managing patients with hypothyroidism, IDA, or their comorbidities.