cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.14844090
title: Supplementary Material for: Dermal Mesenchymal Stem Cells from Psoriatic Lesions Stimulate HaCaT Cell Proliferation, Differentiation, and Migration via Activating the PI3K/AKT Signaling Pathway

description: <b><i>Background:</i></b> Psoriasis is a chronic inflammatory skin disease characterized by excessive proliferation and abnormal differentiation of keratinocytes. Dermal mesenchymal stem cells (DMSCs) are not only involved in the regeneration of skin tissue, but also can regulate skin microenvironment by secreting cytokines. However, whether and how psoriatic DMSCs regulate proliferation and differentiation of keratinocytes remains unknown. <b><i>Objective:</i></b> To study the effects of psoriatic DMSCs on the proliferation, differentiation, and migration of keratinocytes and the underlying mechanisms. <b><i>Methods:</i></b> Following co-cultures of HaCaT cells with either psoriatic DMSCs (p-DMSCs) or DMSCs from normal volunteers (n-DMSCs), HaCaT cell proliferation was assessed using CCK-8 and EDU incorporation assay, while scratch assay and transwell assay were used to assess cell migration. qRT-PCR was used to determine expression levels of mRNA for cell proliferation (Ki-67) and differentiation (keratin 5, involucrin, and filaggrin). Western blot was used to measure expression levels of proteins associated with keratinocyte proliferation and differentiation in cultured HaCaT cells treated with or without PI3K inhibitor. ELISA assay was used to measure expression profile of stem cell factor (SCF), epidermal growth factor (EGF), and interleukin-11 (IL-11) within the co-culture supernatants. <b><i>Results:</i></b> The results showed that p-DMSCs displayed a higher potency than n-DMSCs in stimulating proliferation, differentiation, and migration of HaCaT cells. Expression levels of PI3K and AKT proteins were markedly increased in HaCaT cells co-cultured with DMSCs versus HaCaT cell culture alone. Moreover, inhibition of the PI3K/AKT signaling pathway reversed the effect of p-DMSCs on proliferation, differentiation, and migration of HaCaT cells. Compared with n-DMSCs, the p-DMSCs showed increased secretion of IL-11, EGF, and SCF. <b><i>Conclusion:</i></b> p-DMSCs stimulate HaCaT cell proliferation, differentiation and migration via activating the PI3K/AKT signaling pathway, providing a new insight into the pathogenesis of psoriasis.
DOI: 10.6084/m9.figshare.14844090.v1
title: Supplementary Material for: Dermal Mesenchymal Stem Cells from Psoriatic Lesions Stimulate HaCaT Cell Proliferation, Differentiation, and Migration via Activating the PI3K/AKT Signaling Pathway

description: <b><i>Background:</i></b> Psoriasis is a chronic inflammatory skin disease characterized by excessive proliferation and abnormal differentiation of keratinocytes. Dermal mesenchymal stem cells (DMSCs) are not only involved in the regeneration of skin tissue, but also can regulate skin microenvironment by secreting cytokines. However, whether and how psoriatic DMSCs regulate proliferation and differentiation of keratinocytes remains unknown. <b><i>Objective:</i></b> To study the effects of psoriatic DMSCs on the proliferation, differentiation, and migration of keratinocytes and the underlying mechanisms. <b><i>Methods:</i></b> Following co-cultures of HaCaT cells with either psoriatic DMSCs (p-DMSCs) or DMSCs from normal volunteers (n-DMSCs), HaCaT cell proliferation was assessed using CCK-8 and EDU incorporation assay, while scratch assay and transwell assay were used to assess cell migration. qRT-PCR was used to determine expression levels of mRNA for cell proliferation (Ki-67) and differentiation (keratin 5, involucrin, and filaggrin). Western blot was used to measure expression levels of proteins associated with keratinocyte proliferation and differentiation in cultured HaCaT cells treated with or without PI3K inhibitor. ELISA assay was used to measure expression profile of stem cell factor (SCF), epidermal growth factor (EGF), and interleukin-11 (IL-11) within the co-culture supernatants. <b><i>Results:</i></b> The results showed that p-DMSCs displayed a higher potency than n-DMSCs in stimulating proliferation, differentiation, and migration of HaCaT cells. Expression levels of PI3K and AKT proteins were markedly increased in HaCaT cells co-cultured with DMSCs versus HaCaT cell culture alone. Moreover, inhibition of the PI3K/AKT signaling pathway reversed the effect of p-DMSCs on proliferation, differentiation, and migration of HaCaT cells. Compared with n-DMSCs, the p-DMSCs showed increased secretion of IL-11, EGF, and SCF. <b><i>Conclusion:</i></b> p-DMSCs stimulate HaCaT cell proliferation, differentiation and migration via activating the PI3K/AKT signaling pathway, providing a new insight into the pathogenesis of psoriasis.
DOI: 10.6084/m9.figshare.14844045
title: Supplementary Material for: Adherence to Guideline-Oriented Preventive Measures in Patients with Atopic Dermatitis in Germany

description: <b><i>Background:</i></b> Atopic dermatitis (AD) is a chronic inflammatory skin disease that is often associated with comorbidities and quality of life losses. The implementation of evidence-based preventive measures strengthens patient participation and offers the potential to improve quality of care for AD. <b><i>Objectives:</i></b> To assess adherence to guideline-oriented preventive measures in adult patients with AD in dermatological routine care in Germany. <b><i>Methods:</i></b> The self-responsible application of preventive measures, clinical features, pruritus, disease severity, and duration of disease as well as skin disease-related quality of life were assessed in two independent cross-sectional studies in 2010 and 2017–2019. <b><i>Results:</i></b> Between 2017 and 2019, 706 patients (55.8% female, mean age 41 years) were recruited in a comparable way to the survey in 2010 with 1,678 patients (60.5% female, mean age 38 years). Regular skin care was applied by 99.5% (2010: 94.9%), 90.9% avoided skin irritants (2010: 84.6%), and 80.2% (2010: 61.6%) did not smoke at home. Relaxation techniques were applied by 44.4% (2010: 29.9%). Advice on self-help measures was taken by 36.4% (2010: 27.1%) and 29.2% (2010: 15.4%) attended AD patient education courses. All six preventive measures categorized as obligatory were performed by 13.9% of the patients (2010: 6.7%). Predictors for the number of obligatory preventive measures applied were a high level of education, a longer disease duration, and a lower quality of life. <b><i>Conclusions:</i></b> Although the self-reported use of evidence-based preventive measures in the 2017–2019 study appears to be more frequent than in 2010, important measures are still insufficiently established. Hence, more implementation, including education, is needed to increase the use of guideline-oriented preventive measures.
DOI: 10.25919/6vcv-f787
title: ATACseq of liver, muscle and hypothalamus of three Brahman heifers

description: Liver, hypothalamus, and muscle samples were collected from three unrelated, post-pubertal Brahman heifers of similar age and weight. ATAC-seq libraries were prepared from frozen tissues and sequenced on an Illumina NextSeq 150 cycle (2X 75 bp). Data was used to identify tissue-specific open chromatin regions in indicine cattle and identify master regulators (transcriptions factors) of each tissue.
DOI: 10.5281/zenodo.5031204
title: Prior information for scMLnet

description: Prior L-R-TF-genes information for the tutorial of scMLnet, downloaded from https://github.com/SunXQlab/scMLnet
DOI: 10.5281/zenodo.5031203
title: Prior information for scMLnet

description: Prior L-R-TF-genes information for the tutorial of scMLnet, downloaded from https://github.com/SunXQlab/scMLnet
DOI: 10.3886/e142222v1-90140
title: Emotions, Perceived Stressors and Coping Strategies of Healthcare Workers During the COVID-19 Pandemic

description: Healthcare workers are at a high risk of contracting Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) due to its ability to attack human cells and spread so efficiently. This descriptive study is aimed at exploring emotions and identifying stress and coping strategies of healthcare workers during the pandemic in our hospital
DOI: 10.25919/5d1137055c162
title: Extreme Water Levels for Australian Beaches using Empirical Equations for Shoreline Wave Setup

description: This data is associated with the paper O’Grady, J.G., McInnes, K.L., Hemer, M. A., Hoeke, R. K., Stephenson, A., and Colberg, F. (in press), "Extreme Water Levels for Australian Beaches using Empirical Equations for Shoreline Wave Setup", Journal of Geophysical Research: Oceans. Understanding how high ocean water levels can reach up the coast is important for designing coastal protection from coastal inundation and erosion. This is particularly important as climate change affects wind and weather conditions and sea-level rise with the subsequent modification to the occurrence of the largest storm-driven water levels. While the height of storm-driven water levels are well understood for protected harbours and estuaries, new research is providing estimates of how high water levels can reach for coastlines exposed to dangerous wave/surf conditions. This study uses mathematical model simulations spanning ~30 years of historical water levels and ocean waves. Statistical analysis is performed to determine how high the largest storm events will likely reach on natural sandy beaches directly exposed to large wave/surf conditions. The data comprises Gumbel distribution parameters from regression fitting to the hindcast model data. The file ST_rGUM_25m_sta.1981-2013.nc is for the storm-tide SWL heights from the ROMS storm surge hindcast. The file SU_GT81_rGUM_25m_sta.1981-2013.nc is for wave setup calculated with the Guza, R. T., & Thornton 1981 method. The file SU_GT81_ST_rGUM_25m_sta.1981-2013.nc is for the time-series combined storm-tide and wave setup. Notes: 1) The data datum is relative to the model bathymetry mean sea level (Geoscience Australia’s 2009 250m dataset). Haigh corrected their dataset of storm tide to AHD by comparing modelled 1-year ARI to the tide gauge measurements. “The predicted levels have been artificially adjusted so that the 1-year return period levels exactly match those of the measured estimates at each site. This was done because the predicted water levels are relative to MSL, whereas the measured levels are relative to AHD. Around mainland Australia, AHD was defined using MSL records between 1966 and 1968 at 30 sites and hence differs from present day MSL. Around Tasmania, AHD was defined using two records from 1972.” 2) To convert to AHD, the netcdf file ‘ST_rGUM_25m_sta.1981-2013.nc’ has a variable ‘toAHD’, you will need to add this onto the location parameter ‘mu’. Alternatively add it to the predicted return levels. 3) Wave setup is really only valid for open coastlines exposed to waves, so be careful applying it in estuaries.
DOI: 10.5281/zenodo.5006282
title: Gender differences in scientific careers: A large-scale bibliometric analysis

description: Data set belonging to the paper 'Gender differences in scientific careers: A large-scale bibliometric analysis' (https://arxiv.org/abs/2106.12624).
DOI: 10.25934/00003447.0
title: Available IPD datapackage for study 'A Randomized, Double-blind, Placebo-controlled, Parallel Group Trial Assessing the Proportion of Patients Experiencing an Exacerbation and Proportion of Patients Hospitalized for an Exacerbation Over 6 Months During Treatment With Tiotropium 18 Mcg Capsule Once Daily in Patients With COPD in a Veterans Affairs Setting'

description: Vivli is an independent, non-profit organization that has developed a global data-sharing and analytics platform to serve all elements of the international research community. Our mission is to promote, coordinate, and facilitate scientific sharing and reuse of clinical research data through the creation and implementation of a sustainable global data-sharing enterprise. The Vivli platform includes an independent data repository, in-depth search engine and a cloud-based, secure analytics platform.
DOI: 10.25934/00003447.1
title: IPD datapackage for study 'A Randomized, Double-blind, Placebo-controlled, Parallel Group Trial Assessing the Proportion of Patients Experiencing an Exacerbation and Proportion of Patients Hospitalized for an Exacerbation Over 6 Months During Treatment With Tiotropium 18 Mcg Capsule Once Daily in Patients With COPD in a Veterans Affairs Setting' and research request: 'Heterogeneity in relative treatment efficacy by age, sex, socioeconomic status and comorbidity (McAllister)'

description: Vivli is an independent, non-profit organization that has developed a global data-sharing and analytics platform to serve all elements of the international research community. Our mission is to promote, coordinate, and facilitate scientific sharing and reuse of clinical research data through the creation and implementation of a sustainable global data-sharing enterprise. The Vivli platform includes an independent data repository, in-depth search engine and a cloud-based, secure analytics platform.
DOI: 10.25934/00003441.0
title: Available IPD datapackage for study 'A Randomised, Double-blind, Parallel Group, 12 Week Study, Comparing the Effect of Once Daily Tiotropium Lactose Capsule With Placebo in Patients With Chronic Obstructive Pulmonary Disease (COPD), naïve to Anticholinergic Agents in Addition to Receiving Their Usual COPD Care'

description: Vivli is an independent, non-profit organization that has developed a global data-sharing and analytics platform to serve all elements of the international research community. Our mission is to promote, coordinate, and facilitate scientific sharing and reuse of clinical research data through the creation and implementation of a sustainable global data-sharing enterprise. The Vivli platform includes an independent data repository, in-depth search engine and a cloud-based, secure analytics platform.
DOI: 10.25934/00003441.1
title: IPD datapackage for study 'A Randomised, Double-blind, Parallel Group, 12 Week Study, Comparing the Effect of Once Daily Tiotropium Lactose Capsule With Placebo in Patients With Chronic Obstructive Pulmonary Disease (COPD), naïve to Anticholinergic Agents in Addition to Receiving Their Usual COPD Care' and research request: 'Heterogeneity in relative treatment efficacy by age, sex, socioeconomic status and comorbidity (McAllister)'

description: Vivli is an independent, non-profit organization that has developed a global data-sharing and analytics platform to serve all elements of the international research community. Our mission is to promote, coordinate, and facilitate scientific sharing and reuse of clinical research data through the creation and implementation of a sustainable global data-sharing enterprise. The Vivli platform includes an independent data repository, in-depth search engine and a cloud-based, secure analytics platform.
DOI: 10.25934/00003421.0
title: Available IPD datapackage for study 'Spiriva Assessment of FEV1 - (SAFE-Portugal). The Effect of Inhaled Tiotropium Bromide (18 Mcg Once Daily) on the Change in FEV1 During Treatment in Patients With COPD. A Three-month Parallel Group, Double-blind, Randomised, Placebo-controlled Study.'

description: Vivli is an independent, non-profit organization that has developed a global data-sharing and analytics platform to serve all elements of the international research community. Our mission is to promote, coordinate, and facilitate scientific sharing and reuse of clinical research data through the creation and implementation of a sustainable global data-sharing enterprise. The Vivli platform includes an independent data repository, in-depth search engine and a cloud-based, secure analytics platform.
DOI: 10.25934/00003421.1
title: IPD datapackage for study 'Spiriva Assessment of FEV1 - (SAFE-Portugal). The Effect of Inhaled Tiotropium Bromide (18 Mcg Once Daily) on the Change in FEV1 During Treatment in Patients With COPD. A Three-month Parallel Group, Double-blind, Randomised, Placebo-controlled Study.' and research request: 'Heterogeneity in relative treatment efficacy by age, sex, socioeconomic status and comorbidity (McAllister)'

description: Vivli is an independent, non-profit organization that has developed a global data-sharing and analytics platform to serve all elements of the international research community. Our mission is to promote, coordinate, and facilitate scientific sharing and reuse of clinical research data through the creation and implementation of a sustainable global data-sharing enterprise. The Vivli platform includes an independent data repository, in-depth search engine and a cloud-based, secure analytics platform.
DOI: 10.5281/zenodo.5029174
title: S80 | PFASGLUEGE | Overview of PFAS Uses

description: This is the collection associated with list S80 PFASGLUEGE Overview of PFAS Uses on the NORMAN Suspect List Exchange. https://www.norman-network.com/nds/SLE/ An overview of the uses of per- and polyfluoroalkyl substances (PFAS) from Glüge <em>et al</em> (2020) DOI: 10.1039/D0EM00291G. This data collection contains: Original ESI files (ESI-2.xlsm, ESI-3.xlsm) CC-BY-NC ESI-3 on a single sheet with structure mappings (as XLSX and CSV) PFASGLUEGE substances (unique structural information, as XLSX and CSV) InChIKey and DTXSID mapping files Further work on ESI-2 in progress...
description: Please cite the original work Glüge et al 2020 DOI:10.1039/D0EM00291G when using these data. Files ESI-2 and ESI-3 are for non-commercial use only.
DOI: 10.25934/00003422.0
title: Available IPD datapackage for study 'A Six-Week, Randomized, Double-Blind, Quadruple-Dummy Parallel Group Multiple Dose Study Comparing the Efficacy and Safety of Tiotropium Inhalation Capsules Plus Formoterol Inhalation Capsules to Salmeterol Inhalation Aerosol Plus Fluticasone Inhalation Aerosol in Patients With Chronic Obstructive Pulmonary Disease (COPD)'

description: Vivli is an independent, non-profit organization that has developed a global data-sharing and analytics platform to serve all elements of the international research community. Our mission is to promote, coordinate, and facilitate scientific sharing and reuse of clinical research data through the creation and implementation of a sustainable global data-sharing enterprise. The Vivli platform includes an independent data repository, in-depth search engine and a cloud-based, secure analytics platform.
DOI: 10.25934/00003422.1
title: IPD datapackage for study 'A Six-Week, Randomized, Double-Blind, Quadruple-Dummy Parallel Group Multiple Dose Study Comparing the Efficacy and Safety of Tiotropium Inhalation Capsules Plus Formoterol Inhalation Capsules to Salmeterol Inhalation Aerosol Plus Fluticasone Inhalation Aerosol in Patients With Chronic Obstructive Pulmonary Disease (COPD)' and research request: 'Heterogeneity in relative treatment efficacy by age, sex, socioeconomic status and comorbidity (McAllister)'

description: Vivli is an independent, non-profit organization that has developed a global data-sharing and analytics platform to serve all elements of the international research community. Our mission is to promote, coordinate, and facilitate scientific sharing and reuse of clinical research data through the creation and implementation of a sustainable global data-sharing enterprise. The Vivli platform includes an independent data repository, in-depth search engine and a cloud-based, secure analytics platform.
DOI: 10.5517/ccdc.csd.cc26gqdt
title: CCDC 2039936: Experimental Crystal Structure Determination

description: Related Article: Anuj Kumar, Hemanta K. Kisan, Han Vinh Huynh|2021|Organometallics|40|1699|doi:10.1021/acs.organomet.1c00181
DOI: 10.5517/ccdc.csd.cc26gqfv
title: CCDC 2039937: Experimental Crystal Structure Determination

description: Related Article: Anuj Kumar, Hemanta K. Kisan, Han Vinh Huynh|2021|Organometallics|40|1699|doi:10.1021/acs.organomet.1c00181
DOI: 10.5517/ccdc.csd.cc26gqgw
title: CCDC 2039938: Experimental Crystal Structure Determination

description: Related Article: Anuj Kumar, Hemanta K. Kisan, Han Vinh Huynh|2021|Organometallics|40|1699|doi:10.1021/acs.organomet.1c00181
DOI: 10.5517/ccdc.csd.cc26gqhx
title: CCDC 2039939: Experimental Crystal Structure Determination

description: Related Article: Anuj Kumar, Hemanta K. Kisan, Han Vinh Huynh|2021|Organometallics|40|1699|doi:10.1021/acs.organomet.1c00181
DOI: 10.5281/zenodo.5031272
title: Conformance Assessment of Architectural Design Decisions on API Endpoint Designs Derived from Domain Models: Dataset and Code

description: This is the dataset and related code artifact for the article "Conformance Assessment of Architectural Design Decisions on API Endpoint Designs Derived from Domain Models". <strong>Abstract of the article:</strong> Domain-driven design (DDD) is commonly used, especially in enterprise systems, to design microservices. A crucial aspects of microservice design is API design, which includes the design of API endpoints. In particular, we studied link mapping, API operation design, and resource segregation as API endpoint design issues that are linked to domain model design. Based on Architectural Design Decisions (ADD) studied in a prior empirical study on the interrelation of DDD and APIs, we suggest a new approach for the automated assessment of conformance to ADD options. This approach aims to support the continuous analysis of API endpoint designs. The approach suggests automated detectors to detect ADD options selected in a given API endpoint design, as well as an assessment scoring scheme based on our empirical results. For evaluation of our results, we first manually created a ground truth for 12 cases in a multi-case study, and then compared the results of our automated detectors to the ground truth for each of those cases.
description: This work was also supported by: FFG (Austrian Research Promotion Agency) project DECO, no. 864707.
DOI: 10.5281/zenodo.5025536
title: Conformance Assessment of Architectural Design Decisions on API Endpoint Designs Derived from Domain Models: Dataset and Code

description: This is the dataset and related code artifact for the article "Conformance Assessment of Architectural Design Decisions on API Endpoint Designs Derived from Domain Models". <strong>Abstract of the article:</strong> Domain-driven design (DDD) is commonly used, especially in enterprise systems, to design microservices. A crucial aspects of microservice design is API design, which includes the design of API endpoints. In particular, we studied link mapping, API operation design, and resource segregation as API endpoint design issues that are linked to domain model design. Based on Architectural Design Decisions (ADD) studied in a prior empirical study on the interrelation of DDD and APIs, we suggest a new approach for the automated assessment of conformance to ADD options. This approach aims to support the continuous analysis of API endpoint designs. The approach suggests automated detectors to detect ADD options selected in a given API endpoint design, as well as an assessment scoring scheme based on our empirical results. For evaluation of our results, we first manually created a ground truth for 12 cases in a multi-case study, and then compared the results of our automated detectors to the ground truth for each of those cases.
description: This work was also supported by: FFG (Austrian Research Promotion Agency) project DECO, no. 864707.