cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.10073756.v1
title: A New Electrochemical Platform Based on a Polyurethane Composite Electrode Modified with Magnetic Nanoparticles Coated with Molecularly Imprinted Polymer for the Determination of Estradiol Valerate in Different Matrices

description: A polyurethane composite electrode modified with magnetic nanoparticles (mag; Fe3O4) coated with molecularly imprinted polymers (MIPs) was developed for the electrochemical determination of estradiol valerate. Chemical and morphological analyses of the mag-MIP were performed using scanning electron microscopy (SEM) and energy dispersive X-ray spectroscopy (EDS), with the aim of characterizing this new material. The efficiency of adsorption of estradiol valerate by the mag-MIP was tested in binding experiments using an electrochemical method. For this, different electrodes (mag-MIP / graphite-epoxy composite (GEC), mag-non-imprinted polymer (NIP) / GEC, mag / GEC, and GEC) were evaluated by square-wave voltammetry (SWV). After 10 min at open circuit potential, increases in the current signal of 1.9, 2.1, and 3.0 times were obtained, comparing the electrochemical response of the mag-MIP / GEC sensor to the mag-NIP / GEC, mag / GEC, and GEC sensors, respectively. Under optimized conditions, the mag-MIP / GEC showed a linear concentration range for estradiol valerate of 5.0 × 10-7 to 7.5 × 10-4 mol L-1 and a limit of detection of 1.0 × 10-8 mol L-1. The proposed sensor was applied in the analysis of pharmaceutical, human urine, and river water samples. The recovery values determined using high performance liquid chromatography (HPLC)-UV and the electrochemical method were in agreement and were near 100%, demonstrating the reliability of the proposed method.
DOI: 10.6084/m9.figshare.10073744
title: Nutritional composition and energy values determined with broilers of co-products from the processing of corn ethanol

description: ABSTRACT It was determined by the total collection of excreta method, with broilers from 22 to 32 days of age, the coefficients of apparent metabolism of dry matter, crude protein and crude energy and apparent metabolizable energy corrected for zero nitrogen balance (AMEn) of the ethanol co-products of corn: acid oil and dried distillery grains with soluble (DDGS). The DDGS and corn acid oil presented nutritional metabolization coefficients ranging from 43 to 83% and AMEn equal 2393.5 and 7859.2kcal/kg respectively, and may be food alternatives to soybean meal and soybean oil.
DOI: 10.6084/m9.figshare.10073753.v1
title: Primary multifocal anaplastic large cell lymphoma with eyelid involvement: a case report

description: ABSTRACT Ocular adnexal involvement in CD30+ lymphoproliferative disorders is rare. We report the case of a 73-year-old woman with a relapsing primary cutaneous anaplastic large cell lymphoma on her eyelid. A systemic extension study excluded extracutaneous involvement. Systemic chemotherapy resulted in an optimal response, with complete regression of the cutaneous lesions. There has been no recurrence during the 2 years of follow-up.
DOI: 10.6084/m9.figshare.10073729
title: Misdiagnosis and diagnostic delay in non-paraneoplastic sensory neuronopathies

description: ABSTRACT Sensory neuronopathies (SN) are a group of peripheral nerve disorders characterized by multifocal non-length-dependent sensory deficits and sensory ataxia. Its recognition is essential not only for proper management but also to guide the etiological investigation. The uncommon SN clinical picture and its rarity set the conditions for the misdiagnosis and the diagnostic delay, especially in non-paraneoplastic SN. Therefore, our objectives were to characterize the diagnostic odyssey for non-paraneoplastic SN patients, as well as to identify possible associated factors. Methods We consecutively enrolled 48 non-paraneoplastic SN patients followed in a tertiary neuromuscular clinic at the University of Campinas (Brazil). All patients were instructed to retrieve their previous medical records, and we collected the data regarding demographics, disease onset, previous incorrect diagnoses made and the recommended treatments. Results There were 34 women, with a mean age at the diagnosis of 45.9 ± 12.2 years, and 28/48 (58%) of the patients were idiopathic. Negative sensory symptoms were the heralding symptoms in 25/48 (52%); these were asymmetric in 36/48 (75%) and followed a chronic course in 35/48 (73%). On average, it took 5.4 ± 5.3 years for SN to be diagnosed; patients had an average of 3.4 ± 1.5 incorrect diagnoses. A disease onset before the age of 40 was associated to shorter diagnosis delay (3.7 ± 3.4 vs. 7.8 ± 6.7 years, p = 0.01). Conclusions These results suggest that diagnostic delay and misdiagnosis are frequent in non-paraneoplastic SN patients. As in other rare conditions, increased awareness in all the healthcare system levels is paramount to ensure accurate diagnosis and to improve care of these patients.
DOI: 10.6084/m9.figshare.10073744.v1
title: Nutritional composition and energy values determined with broilers of co-products from the processing of corn ethanol

description: ABSTRACT It was determined by the total collection of excreta method, with broilers from 22 to 32 days of age, the coefficients of apparent metabolism of dry matter, crude protein and crude energy and apparent metabolizable energy corrected for zero nitrogen balance (AMEn) of the ethanol co-products of corn: acid oil and dried distillery grains with soluble (DDGS). The DDGS and corn acid oil presented nutritional metabolization coefficients ranging from 43 to 83% and AMEn equal 2393.5 and 7859.2kcal/kg respectively, and may be food alternatives to soybean meal and soybean oil.
DOI: 10.6084/m9.figshare.10073726
title: Morphometry and population of preantral follicles of not pregnant Nelore cows, pregnant and fetus in the initial, medium and final third of pregnancy

description: ABSTRACT The aim of this study was to describe population and morphological characteristics of preantral follicles of not pregnant cows, pregnant cows and fetus. Ten ovaries of non-pregnant Nelore cows, eighteen ovaries of pregnant cows and eighteen ovaries of fetus were used. For pregnant cows, six ovaries from each third (initial, middle and final) were evaluated, acquired from a slaughterhouse. For fetus, the same methodology and proportion of ovaries were used. Ovaries were washed, fixed and embedded in paraffin. They were then sectioned in longitudinal sections and stained by the Hematoxylin-Eosin method. Preantral follicles were classified according to morphology (primordial, primary and secondary) and degree of viability (intact and in initial, moderate and marked atresia). Descriptive and statistical analyzes were performed through KS300 image analysis program and Tukey’s test. A greater proportion of primordial follicles were found in all categories. Secondary follicles were not observed in ovaries of fetus and cows in the initial third of pregnancy. All the ovary dimensions were higher in non-pregnant cows and in the final third of cows' pregnancy, and lower in final third of pregnancy fetus. It was concluded that follicle isolation was effective in describing population and morphological characteristics of preantral follicles of cows and fetus.
DOI: 10.6084/m9.figshare.10073723
title: From Charcot’s descriptions to the current understanding of neuropsychiatric symptoms in multiple sclerosis

description: ABSTRACT Neuropsychiatric disorders in multiple sclerosis have been known since the original clinicopathological description by Charcot in the late nineteenth century. Charcot, in the last decades of his life, became involved in the field of neuropsychiatry. This produced a battle between rival schools in the era that still echoes to this day. Charcot’s intuition, including the line of thought of Babinski, one of his most famous disciples, was that there was a connection between mood disorders and many of the diseases of the nervous system. Medicine’s concern with establishing a relationship between mood disorders and disease stems from the ancient and middle ages with references found in the Hippocratic doctrine. However, it was only in the second half of the nineteenth and early twentieth century, with Charcot’s discoveries, that this discussion was established in a structured way, laying the foundations of neuropsychiatry.
DOI: 10.6084/m9.figshare.10073729.v1
title: Misdiagnosis and diagnostic delay in non-paraneoplastic sensory neuronopathies

description: ABSTRACT Sensory neuronopathies (SN) are a group of peripheral nerve disorders characterized by multifocal non-length-dependent sensory deficits and sensory ataxia. Its recognition is essential not only for proper management but also to guide the etiological investigation. The uncommon SN clinical picture and its rarity set the conditions for the misdiagnosis and the diagnostic delay, especially in non-paraneoplastic SN. Therefore, our objectives were to characterize the diagnostic odyssey for non-paraneoplastic SN patients, as well as to identify possible associated factors. Methods We consecutively enrolled 48 non-paraneoplastic SN patients followed in a tertiary neuromuscular clinic at the University of Campinas (Brazil). All patients were instructed to retrieve their previous medical records, and we collected the data regarding demographics, disease onset, previous incorrect diagnoses made and the recommended treatments. Results There were 34 women, with a mean age at the diagnosis of 45.9 ± 12.2 years, and 28/48 (58%) of the patients were idiopathic. Negative sensory symptoms were the heralding symptoms in 25/48 (52%); these were asymmetric in 36/48 (75%) and followed a chronic course in 35/48 (73%). On average, it took 5.4 ± 5.3 years for SN to be diagnosed; patients had an average of 3.4 ± 1.5 incorrect diagnoses. A disease onset before the age of 40 was associated to shorter diagnosis delay (3.7 ± 3.4 vs. 7.8 ± 6.7 years, p = 0.01). Conclusions These results suggest that diagnostic delay and misdiagnosis are frequent in non-paraneoplastic SN patients. As in other rare conditions, increased awareness in all the healthcare system levels is paramount to ensure accurate diagnosis and to improve care of these patients.
DOI: 10.6084/m9.figshare.10073717
title: Conservation status and bio-ecology of Brycon orbignyanus (Characiformes: Bryconidae), an endemic fish species from the Paraná River basin (Brazil) threatened with extinction

description: ABSTRACT Brycon orbignyanus is an endemic species from La Plata basin whose stocks have been presenting significant reductions throughout the Paraná River. Brycon orbignyanus is categorized as an endangered species. This study evaluated aspects of the bio-ecology of this species that may be related to this threat, highlighting its distribution, abundance, and diet as well as the corresponding relationships between its recruitment and flood regimes. Data were obtained from different parts of the upper Paraná River (stretches free and regulated by dams) from 1986 to 2010 with more detailed data collected from the free remnant of this basin. The results indicate that no records for species exist at more than half of the sampling points located in dam-regulated sections of the Paraná River, whereas specimens were collected from 75% sites in the free plain remnant. We observed a remarkable effect of the hydrological regime on recruitment as well as distinct food demands during ontogenetic development, with adults almost exclusively consuming fruits and seeds, revealing that these individuals are supported by riparian vegetation. Thus, it is concluded that changes in the natural flood regime as well as riparian vegetation removal threaten B. orbignyanus populations in the Paraná River basin.
DOI: 10.6084/m9.figshare.10073723.v1
title: From Charcot’s descriptions to the current understanding of neuropsychiatric symptoms in multiple sclerosis

description: ABSTRACT Neuropsychiatric disorders in multiple sclerosis have been known since the original clinicopathological description by Charcot in the late nineteenth century. Charcot, in the last decades of his life, became involved in the field of neuropsychiatry. This produced a battle between rival schools in the era that still echoes to this day. Charcot’s intuition, including the line of thought of Babinski, one of his most famous disciples, was that there was a connection between mood disorders and many of the diseases of the nervous system. Medicine’s concern with establishing a relationship between mood disorders and disease stems from the ancient and middle ages with references found in the Hippocratic doctrine. However, it was only in the second half of the nineteenth and early twentieth century, with Charcot’s discoveries, that this discussion was established in a structured way, laying the foundations of neuropsychiatry.
DOI: 10.6084/m9.figshare.10073726.v1
title: Morphometry and population of preantral follicles of not pregnant Nelore cows, pregnant and fetus in the initial, medium and final third of pregnancy

description: ABSTRACT The aim of this study was to describe population and morphological characteristics of preantral follicles of not pregnant cows, pregnant cows and fetus. Ten ovaries of non-pregnant Nelore cows, eighteen ovaries of pregnant cows and eighteen ovaries of fetus were used. For pregnant cows, six ovaries from each third (initial, middle and final) were evaluated, acquired from a slaughterhouse. For fetus, the same methodology and proportion of ovaries were used. Ovaries were washed, fixed and embedded in paraffin. They were then sectioned in longitudinal sections and stained by the Hematoxylin-Eosin method. Preantral follicles were classified according to morphology (primordial, primary and secondary) and degree of viability (intact and in initial, moderate and marked atresia). Descriptive and statistical analyzes were performed through KS300 image analysis program and Tukey’s test. A greater proportion of primordial follicles were found in all categories. Secondary follicles were not observed in ovaries of fetus and cows in the initial third of pregnancy. All the ovary dimensions were higher in non-pregnant cows and in the final third of cows' pregnancy, and lower in final third of pregnancy fetus. It was concluded that follicle isolation was effective in describing population and morphological characteristics of preantral follicles of cows and fetus.
DOI: 10.6084/m9.figshare.10073711
title: Endovascular closure of patent foramen ovale: a critical appraisal of published trials

description: ABSTRACT The treatment of cryptogenic stroke patients with a patent foramen ovale (PFO) is controversial. A critical review of these studies is presented. Methods A description of all trials comparing medical and endovascular treatment with closing devices is given. Additional pertinent studies are discussed to help construct a rational basis for treatment decisions. Results Initial negative trials evaluating PFO closure were followed by positive studies published in 2017 and 2018. All trials evaluated young patients (up to 60 years). Methodological problems are present in all trials including their open label construction. Most positive trials developed strategies to increase the percentage of patients with interatrial septal aneurysms or hypermobility and large right-to-left shunts. Even in these positive trials, large numbers of patients need to be treated to avoid one stroke. Atrial fibrillation occurred in 2-6% and other adverse effects related to the procedure and to the devices occurred in a substantial number of patients. Incomplete occlusion of the PFO is also frequent. Anticoagulant treatment has not been adequately studied as a therapeutic option. Conclusion Young patients with cryptogenic strokes seem to benefit from endovascular closure of a PFO in the presence of a large right-to-left shunt or an associated atrial septum aneurysm. For most other patients, a highly-individualized decision must be made, taking into account the low risk of recurrence in patients with a cryptogenic stroke attributable to a PFO, the high numbers needed to treat and the risks related to the procedure.
DOI: 10.6084/m9.figshare.10073714
title: Brazilian assessment on biodiversity and ecosystem services: summary for policy makers

description: Abstract: Biodiversity and ecosystems are important elements for addressing national and global socioeconomic and environmental crises, since they provide new development opportunities, for example, as source of job and income creation, and reduction in poverty and socioeconomic inequity. Brazilian biological diversity is also expressed in its immense cultural diversity, with a great variety of knowledge holders. These peoples possess vast knowledge on agrobiodiversity, fishing, fire management, natural medicine, among others of commercial, cultural and spiritual value. The main conclusions of this Summary for Police Makers is that land use changes and climate changes have been - and will continue to be throughout this century - the main drivers that result in the loss of biodiversity and ecosystem services in the country. Political interventions at different levels (from local to national, from public to private) and the enforcement of existing laws (regulatory mechanisms and incentives) are required to cope with the mitigation of the negative impacts of biodiversity and ecosystem services loss. Brazil has already a wide variety of policy instruments and socioenvironmental governance options, as well as global commitments (ODS, Aich Targets, Paris Agreement) related to the objective of a sustainable future. However, inefficient management control or lack of incentive to comply with the rules pose risks to consolidating the path to this future. The country has strong and capable institutions, but infrastructural problems, slow processes, inefficient measurements and judicial, social and ecological conflicts obstruct a proficient performance. There is a lack of communication between science and society which needs to be improved by establishing an effective flow that makes communication inclusive and representative, reaching public and private decision makers. Permanent efforts to integrate Science and policy knowledges are desirable to build confidence between policy makers and researchers.
DOI: 10.6084/m9.figshare.10073717.v1
title: Conservation status and bio-ecology of Brycon orbignyanus (Characiformes: Bryconidae), an endemic fish species from the Paraná River basin (Brazil) threatened with extinction

description: ABSTRACT Brycon orbignyanus is an endemic species from La Plata basin whose stocks have been presenting significant reductions throughout the Paraná River. Brycon orbignyanus is categorized as an endangered species. This study evaluated aspects of the bio-ecology of this species that may be related to this threat, highlighting its distribution, abundance, and diet as well as the corresponding relationships between its recruitment and flood regimes. Data were obtained from different parts of the upper Paraná River (stretches free and regulated by dams) from 1986 to 2010 with more detailed data collected from the free remnant of this basin. The results indicate that no records for species exist at more than half of the sampling points located in dam-regulated sections of the Paraná River, whereas specimens were collected from 75% sites in the free plain remnant. We observed a remarkable effect of the hydrological regime on recruitment as well as distinct food demands during ontogenetic development, with adults almost exclusively consuming fruits and seeds, revealing that these individuals are supported by riparian vegetation. Thus, it is concluded that changes in the natural flood regime as well as riparian vegetation removal threaten B. orbignyanus populations in the Paraná River basin.
DOI: 10.6084/m9.figshare.10073708
title: Factors Associated to the Knowledge of Cardiac Arrest by Health Professionals

description: Abstract Background: Knowledge of cardiac arrest by health professionals is associated with sociodemographic, occupational and training characteristics. Objectives: To evaluate the factors associated with the knowledge of health professionals on Cardiac Arrest. Methods: A cross-sectional study conducted in a large public hospital in the countryside of Bahia - Brazil. The sample consisted of 18 doctors, 32 nurses and 50 nursing technicians. To evaluate the knowledge of the professionals, a questionnaire was constructed according to the current guidelines for resuscitation of the American Heart Association of 2015, and after that, it was submitted to three judges with expertise in PCR to verify content validity. Data were analyzed through descriptive statistics with univariate, bivariate and multivariate analyses using the logistic regression model. A value of p &lt; 0.05 was adopted as level of significance. Results: The prevalence of insufficient knowledge of cardiac arrest among health professionals was 78%. After logistic regression, belonging to the professional category of nursing technician (p = 0.003) and nurse (p = 0.001) and working in the form of on-call duty for 24h (p = 0.005) was associated to insufficient knowledge. Conclusions: Insufficient knowledge of cardiac arrest among health professionals is high, which is a problem that requires urgent interventions in order to guarantee the quality of care. These actions should be based on realistic scenarios involving theoretical and practical activities. The periodicity of training should be short, given the deterioration of knowledge. The creation and validation of the data collection instrument allows for its applicability in other studies.
DOI: 10.6084/m9.figshare.10073699
title: A new synonym for Micropholis gardneriana (Sapotaceae) with complete description, anatomy and distribution notes

description: Abstract: In the present work, we synonymize Micropholis compta under M. gardneriana due to the overlap of morphoanatomical characters and the absence of distinctive attributes, verified during taxonomic and anatomical study of the genus Micropholis for Brazil. This study provides an updated description of M. gardneriana, including macro- and micro-morphological data, a distribution map, and comments on conservation status, ecological and taxonomy.
DOI: 10.6084/m9.figshare.10073702
title: Comparative study between reticulating agents for possible application in the treatment of keratoconus

description: ABSTRACT With the present study, we aimed to compare the standard technique of CXL with the treatment using genipine as a crosslinker, with and without corneal de-epithelialization. The chemical, mechanical and morphological properties of pig corneas submitted to crosslinking treatments with riboflavin and genipine were compared, as well as to compare the cytotoxicity of the crosslinking solutions for possible application in keratoconus. The corneas were divided into four groups: riboflavin and UVA according to standard treatment,genipina with epithelium off, genipina with epithelium on and control without crosslinker. In this way, the corneas were submitted to the characterizations and analyzed by the following techniques: OM, SEM, traction test, dilatometry and swelling. The cytotoxicity analysis was performed comparing the standard treatment with genipine. The results demonstrate a greater tensile strength, as well as more swelling when genipine was applied to the epithelium off corneal surface. The downward slopes in the dilatometry curve are linear in the UV-CXL and control, and with genipine, the contraction tends to become more pronounced at higher temperatures. By MEV was able to demonstrate a dmarcation line in the corneal stroma treated with UV-CXL or genipine and OM exhibits different patterns of transmitted light in the different groups, demonstrating greater UV-CXL opacity. The corneal collagen crosslinking induced by 0.1% genipine produces an increase in corneal resistance without causing considerable corneal opacity and may be useful in the treatment of keratoconus. The potential for cytotoxicity to fibroblasts was similar between crosslinking methods.