cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.5539855.v1
title: Supplementary Material for: Isolated Cleft Lip and Palate: Maxillary Gap Sign and Palatino-Maxillary Diameter at 11–13 Weeks

description: <b><i>Objective:</i></b> To evaluate the maxillary gap sign and describe markers for the first-trimester diagnosis of isolated cleft lip and palate (CLP) at 11–13 weeks. <b><i>Methods:</i></b> Firstly, this was a prospective assessment of 1,087 fetuses including 5 cases of isolated CLP in 2 centers which were referred for the 11–13 weeks scan. Secondly, intra- and interobserver variability of the maxillary gap sign was evaluated for observers R.L. and A.B. in 2 sessions (affected cases vs. 50 normal fetuses in each session) to reduce the bias of different ultrasound manufacturer visualizations (Philips, GE). Thirdly, the palatino-maxillary diameter (PMD) was examined in stored images, DICOM loops and volumes of the midsagittal and parasagittal view of the fetal head and brain at 11<sup>+0</sup>–13<sup>+6</sup> weeks of gestation from 5 fetuses with isolated CLP and 302 consecutively assessed normal controls. The PMD values in fetuses with isolated CLP and normal controls were compared. <b><i>Results:</i></b> Firstly, 5 out of 6 referred pregnancies with isolated CLP were detected prospectively using the midsagittal view for measurement of nuchal translucency due to an abnormal appearance. One out of 6 patients with isolated CLP declined the 11–13 weeks scan. Secondly, intra- and interobserver variability showed no false positive cases; all cases with isolated CLP were identified by both sonographers; however, in 2 cases the maxillary gap sign was doubtful. Therefore, thirdly, we developed the PMD measurement which increased significantly with crown-rump length (CRL) from respective mean values at CRL of 45 mm to 4.66 mm and to 8.95 mm at CRL of 84 mm. In the CLP group, the PMD was below the 5th percentile of the control group in 4 out of 5 (80%) cases. <b><i>Conclusions:</i></b> The midsagittal view for measurement of nuchal translucency shows a high reproducibility regarding abnormal views for maxillary gap sign. In the midsagittal view of the fetal head, face, and brain at 11–13 weeks, the majority of fetuses with isolated CLP have a measurable abnormality in addition, the PMD.
DOI: 10.6084/m9.figshare.6152294.v1
title: How strong was the bottleneck associated to the peopling of the Americas? New insights from multilocus sequence data

description: Abstract In spite of many genetic studies that contributed for a deep knowledge about the peopling of the Americas, no consensus has emerged about important parameters such as the effective size of the Native Americans founder population. Previous estimates based on genomic datasets may have been biased by the use of admixed individuals from Latino populations, while other recent studies using samples from Native American individuals relied on approximated analytical approaches. In this study we use resequencing data for nine independent regions in a set of Native American and Siberian individuals and a full-likelihood approach based on isolation-with-migration scenarios accounting for recent flow between Asian and Native American populations. Our results suggest that, in agreement with previous studies, the effective size of the Native American population was small, most likely in the order of a few hundred individuals, with point estimates close to 250 individuals, even though credible intervals include a number as large as ~4,000 individuals. Recognizing the size of the genetic bottleneck during the peopling of the Americas is important for determining the extent of genetic markers needed to characterize Native American populations in genome-wide studies and to evaluate the adaptive potential of genetic variants in this population.
DOI: 10.6084/m9.figshare.26333968.v1
title: Supplementary Material for: Therapeutic host anticancer immune response through photoimmunotherapy for head and neck cancer may overcome resistance to immune checkpoint inhibitors

description: Introduction: Near-infrared photoimmunotherapy (NIR-PIT) is a recently developed hybrid cancer therapy that directly kills cancer cells while producing a therapeutic host anticancer immune response. The activation of host immunity using NIR-PIT can enhance the effects of immune checkpoint inhibitors (ICIs) in animal experimental models; however, there have been no reports of this phenomenon in humans. Furthermore, by activating host immunity using NIR-PIT in patients who have become resistant to ICIs, the effects of ICIs can be restored.
Case Presentation: A 56-year-old male experienced local recurrence after chemoradiotherapy for maxillary sinus cancer (cT4bN0M0). The disease had progressed following ICI antiPD-1 antibody therapy. He underwent NIR-PIT for four cycles; however, a local recurrent tumor remained and began a rapid regrowth. The immune checkpoint inhibitor antiPD-1 antibody was then readministered following NIR-PIT. As a result, sensitivity to antiPD-1 therapy was restored, and the tumor shrank. Finally, a complete response was observed without major adverse events associated with subsequent antiPD-1 antibody treatment following NIR-PIT. Conclusion: These results indicated that NIR-PIT may not only activate host anticancer immunity but also enhance the effects of ICIs and overcome antiPD-1 resistance.
DOI: 10.6084/m9.figshare.26124766.v1
title: Supplementary Material for: Development of a Patient-Centered Pathway of Care for Retinoblastoma Patients: A Mixed-Methods Pilot Study

description: Introduction 

Retinoblastoma treatment and follow-up is complex and varies between patients. Pathways of care can enhance quality of care, patient outcomes, safety, satisfaction, and resource optimization. Developing a pathway of care for retinoblastoma was identified as a top research priority by the retinoblastoma community. This study aimed to co-design and pilot a pathway of care called the “Retinoblastoma Journey Map” tailored for caregivers of newly diagnosed children with retinoblastoma. 

Methods 

A working group of patients, health professionals and researchers used human-centred design to ideate, prototype and refine the Retinoblastoma Journey Map. Caregivers of affected children were recruited to use and evaluate the Map. Mixed-methods data was collected on feasibility, acceptability, usability and perceived impact on communication, self-efficacy, anxiety, depression, and the quality of physician-patient interaction. 

Results 

The Retinoblastoma Journey Map consisted of an illustrated roadmap with 25 child-friendly stickers covering clinical treatment, medical education and milestones. Quantitative analysis revealed that the Map was feasible, acceptable, and usable; however, no significant effect on communication, self-efficacy, anxiety, depression or quality of physician-patient interaction was observed. Qualitative analysis identified 6 themes: Primary Use, Challenges, Impact, Limitations, Feasibility, Acceptability and Usability, and Unmet Needs. 

Conclusion 

A pathway of care for retinoblastoma, co-designed by researchers, health professionals and patients, was usable, acceptable, and feasible by caregivers of children with retinoblastoma. While significant effects on communication and physician-patient interaction were not observed, ‘legacy building’ – documentation of the pathway of care by families for later education of their child – emerged as an unanticipated yet important use of the Retinoblastoma Journey Map.
DOI: 10.6084/m9.figshare.28784984.v1
title: Table 4

description: <b>Cluster Membership</b> of countries
DOI: 10.6084/m9.figshare.19923772.v1
title: The Brazilian LGBT+ Health Survey: methodology and descriptive results

description: The understanding of health care demands and possible access barriers may support policymaking and best practices targeting the lesbian, gay, bisexual, transgender, and related identities (LGBT+) population. The aims of the Brazilian LGBT+ Health Survey were to characterize the LGBT+ population during the COVID-19 pandemic and to specify the characteristics of the COVID-19 pandemic in this population. This is a cross-sectional online study, with a convenience sample of 976 individuals identified as LGBT+, aged 18 years or older from Brazil. It allows investigations of sexuality, discrimination, internal homophobia, health-related behaviors, and health care access. The study adopts a conceptual framework (i.e., validated tools and measures) common to other epidemiological studies, allowing comparisons. We describe the study methodology, some descriptive results, and health-selected indicators compared with the Brazilian National Health Survey. Most of the respondents were from Southeast Region (80.2%), mean aged 31.3 (± 11.5 years). Regarding COVID-19, 4.8% tested positive. Both weekly episodes of discrimination (36%) and depression prevalence (24.8%) were high among the LGBT+ population in Brazil, highlighting mental health and homophobia as major concerns in the LGBT+ context during the pandemic. Although a decade has passed since the institution of the Brazilian National Policy for Comprehensive LGBT Health, appropriate training of health professionals to offer adequate services is still needed. Knowledge of the specific health demands of this group might guide person-centered best practices, promote sexual minority high-acceptance settings, and contribute to higher equity during the pandemic.
DOI: 10.6084/m9.figshare.20097350.v1
title: JAL raw data.xls

description: This excel file provide the raw data involving exponential parameters, AUDPC, dissease onset time recorded for the wheat-stem-rust pathosystem. Authors attempted to determine the best descriptors of wheat stem rust progress in different cultivars planted at various dates.
DOI: 10.6084/m9.figshare.28587839.v1
title: Supplementary Material for: Timing of renal transplant in survivor children with relapse of Wilms tumor, a case series study

description: IIntroduction: Children with Wilms tumor can rarely experience late relapse of disease. Sometimes bilateral nephrectomy is necessary, as consequence, patient needs hemodialysis waiting for renal transplantation. The waiting time to transplantation after cancer has always been debated issue. Case presentations: We present two cases of late relapse of Wilms tumor underwent bilateral nephrectomy. Patient 1 was put in the attending list for renal transplant after 5 years to the stop treatment, attending the conventionally time; however she died before transplant because of complications in Sars-Covid-19 infection. Patient 2 underwent to renal transplant sooner compared to the conventional time, improving her quality of life and alive. Conclusion: If bilateral nephrectomy is necessary, in oncological patients, the timing of renal transplant should be discussed in multidisciplinary team. In our cases the different time to renal transplantation was associated to different outcome. Clinicians should have common lines about the time of renal transplantation in pediatric oncology, however a personalized planning could be suggested after discussion among specialists, evaluating case to case. The presented field needs more knowledge and further larger case series are necessary to evaluate outcome related timing of renal transplant; in this view collaboration between oncology centres is strongly required
DOI: 10.6084/m9.figshare.4585264.v1
title: Supplementary Material for: Comparison of Dolphins' Body and Brain Measurements with Four Other Groups of Cetaceans Reveals Great Diversity

description: We compared mature dolphins with 4 other groupings of mature cetaceans. With a large data set, we found great brain diversity among 5 different taxonomic groupings. The dolphins in our data set ranged in body mass from about 40 to 6,750 kg and in brain mass from 0.4 to 9.3 kg. Dolphin body length ranged from 1.3 to 7.6 m. In our combined data set from the 4 other groups of cetaceans, body mass ranged from about 20 to 120,000 kg and brain mass from about 0.2 to 9.2 kg, while body length varied from 1.21 to 26.8 m. Not all cetaceans have large brains relative to their body size. A few dolphins near human body size have human-sized brains. On the other hand, the absolute brain mass of some other cetaceans is only one-sixth as large. We found that brain volume relative to body mass decreases from Delphinidae to a group of Phocoenidae and Monodontidae, to a group of other odontocetes, to Balaenopteroidea, and finally to Balaenidae. We also found the same general trend when we compared brain volume relative to body length, except that the Delphinidae and Phocoenidae-Monodontidae groups do not differ significantly. The Balaenidae have the smallest relative brain mass and the lowest cerebral cortex surface area. Brain parts also vary. Relative to body mass and to body length, dolphins also have the largest cerebellums. Cortex surface area is isometric with brain size when we exclude the Balaenidae. Our data show that the brains of Balaenidae are less convoluted than those of the other cetaceans measured. Large vascular networks inside the cranial vault may help to maintain brain temperature, and these nonbrain tissues increase in volume with body mass and with body length ranging from 8 to 65% of the endocranial volume. Because endocranial vascular networks and other adnexa, such as the tentorium cerebelli, vary so much in different species, brain size measures from endocasts of some extinct cetaceans may be overestimates. Our regression of body length on endocranial adnexa might be used for better estimates of brain volume from endocasts or from endocranial volume of living species or extinct cetaceans.
DOI: 10.6084/m9.figshare.12662645.v1
title: Gene clusters potentially associated with environmental adaptation, bioremediation, biocontrol, and plant-growth promotion in H. alvei A23BA

description: Gene clusters potentially associated with environmental adaptation, bioremediation, biocontrol, and plant-growth promotion in <i>H. alvei</i> A23BA
DOI: 10.6084/m9.figshare.24792744.v1
title: Supplementary Material for: The matter of kidney biopsy in Monoclonal Gammopathy of Renal Significance: a case report of a new pattern of Immunoglobulin-Storing Histiocytosis

description: The acronym MGRS represents a group of disorders, characterized by paraproteinemia which causes renal damage. These disorders never meet the diagnostic criteria for multiple myeloma (MM) or lymphoproliferative disease. Crystal-storing histiocytosis (CSH) is one of the rarest patterns of MGRS, characterized by an accumulation of light chains crystals within histiocyte’s cytoplasm, located in bone marrow or other extramedullary sites such as kidney, cornea, or thyme. A very few cases have been described as Immunoglobulin-storing histiocytosis (IgSH) without evidence of crystals. In the recent literature, only 3 cases of IgSH have been described so far, none renal. In all cases, these very peculiar histopathological patterns are associated with lymphoproliferative or plasma cellular disorders. Here, we report a very unusual IgSH pattern in a kidney biopsy, which led to prompt detection and early therapeutic intervention, in a patient with otherwise misdiagnosed MGRS.
DOI: 10.6084/m9.figshare.26310520.v1
title: DRUG-seq data.txt

description: We provided the sequencing data obtained from this DRUG-seq experiment, including 364 treatments and 20 controls.We also provided all the metabolites used in this experiment along with their detailed information.The CIBERSORT results were also presented.
DOI: 10.6084/m9.figshare.92045.v2
title: Arduino 3x3 LED cube Project Data

description: Data used in the building process of my LED 3x3 cube. The pin output voltage was taken to see the consistencies of the voltage between pins. This also confirmed the Arduino Uno was working properly. The potential difference between the cathode and ground can be used to make a rough calculation of the current going though the LEDs using Ohm's Law.
DOI: 10.6084/m9.figshare.5422858.v1
title: Ultrasonographic changes in the liver tumors as indicators of adequate tumor coverage with electric field for effective electrochemotherapy

description: Aim of the study was to characterize ultrasonographic (US) findings during and after electrochemotherapy of liver tumours to determine the actual ablation zone in order to verify the coverage of the treated tumour with sufficiently strong electric field for effective electrochemotherapy. US findings from two representative patients that describe the immediate and delayed tumour changes after electrochemotherapy of colorectal liver metastases are presented. The US findings were interrelated with magnetic resonance imaging (MRI). Electrochemotherapy-treated tumours were exposed to electric pulses based on computational treatment planning. The US findings indicate the immediate appearance of hyperechogenic microbubbles along the electrode tracks. Within minutes, the tumours became evenly hyperechogenic, and simultaneously, an oedematous rim was formed presenting as a hypoechogenic formation which persisted for several hours after treatment. The US findings overlapped with the computed electric field distribution in the treated tumours, indicating adequate coverage of the tumours with the sufficiently strong electric field, which may predict an effective treatment outcome. US provides a tool for assessment of appropriate electrode insertion for intraoperative electrochemotherapy of liver tumours and as indicator of the appropriate coverage of a tumour with a sufficiently strong electric field and predictor of the response of tumours. <br>
DOI: 10.6084/m9.figshare.1138736.v1
title: LAS files 2012 Santorini LiDAR dataset EU-12-12-137

description: LAS format LiDAR point cloud data from the NERC Airborne Research and Survey Facility campaign to Santorini, Greece, in May 2012 - EU-12-12-137. 13 flightlines in total. Data are analysed in an open access paper in GeoResJ by Nomikou et al., 2014 - http://dx.doi.org/10.1016/j.grj.2014.02.002
DOI: 10.6084/m9.figshare.24258565.v2
title: SNP PubMed Abstracts Text Corpus

description: Abstracts fetched are stored in a JSON file named `cached_abstracts.json`. In cases where an abstract is not available for a PMID, that PMID is recorded in a separate TSV file named `no_abstract.tsv`.- `read_pmids_from_file`: Extracts and returns unique PMIDs from file snp_mutation_data.tsv (Contains all the PMID where SNP's context is present).
DOI: 10.15482/usda.adc/1522618
title: Bradysia coprophila genome annotations Bcop_v1.0
DOI: 10.6084/m9.figshare.12933938.v1
title: Quantitative Evaluation of apparent diffusion coefficient in a large multi-unit institution using the QIBA diffusion phantom [Data Repository]

description: A sampling of 23 clinical MRI scanners was investigated in this study. DWI acquisitions with ADC reporting are performed in all of these scanners allowing for patients to be scheduled for iterative evaluation and serial imaging across different device manufacturers, models, field strengths, and acquisition parameters. In order to assess harmonization and standardization across the fleet for developing, implementing and continuously assessing a quality control program for quantitative biomarker imaging we provide an initial characterization of the variance in our institutional DWI and ADC performance across our fleet using a newly constructed jointly developed NIST/QIBA DWI phantoms (High Precision Devices Inc., Boulder, CO, USA). We also hope to utilize this information to categorize our scanners by vendor, platform, or field strength by those which are closest in terms of ADC accuracy, so that, if necessary, patients can be selectively triaged to scanners which most closely approximate the machine of their initial imaging.This initial benchmarking of the scanners using the QIBA protocol is the precursor to longitudinal assessment amongst scanners for quality assurance as well as later lending to the investigation of variance introduced by specific clinical protocols and advanced acquisition techniques (e.g., multi-shot, simultaneous multi-slice encoding, etc).
DOI: 10.6084/m9.figshare.7855574.v1
title: Splitting the spotlight? Evidence from attentional capture by successive events

description: Please refer to the manuscript attached to this project
DOI: 10.60893/figshare.jcp.27636879.v1
title: Supplemental Materials

description: 1. Electronic Derivative Couplings
2. Vibrational Analysis
3. Cartesian Coordinates of The Molecules
4. Linewidth in The SCM Scenario
DOI: 10.15468/dl.85gk8e
title: Occurrence Download

description: A dataset containing 6280 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Sporobolus alterniflorus (Loisel.) P.M.Peterson & Saarela"
 ]
}

 The dataset includes 6280 records from 327 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0009669-250426092105405/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.6084/m9.figshare.5215789.v1
title: Data sets for the article with doi: 10.3389/fpls.2017.01296 Establishing the Bases for Introducing the Unexplored Portuguese Common Bean Germplasm into the Breeding World

description: SSR screening of a Portuguese common bean collection and Andean and Mesoamerican race representatives and wild relatives (from CIAT seed bank).<br>Supplementary data of manuscript with doi: 10.3389/fpls.2017.01296<br><br>
DOI: 10.6084/m9.figshare.25721592.v1
title: <b>Supplemental Material</b>

description: Supplemental material to the manuscript: <i>Identification of natriuretic peptide receptor A (NPR-A)-related gene expression signatures in podocytes</i><i> </i><i>in vivo</i><i> </i><i>reveals baseline control of protective pathways</i>
DOI: 10.6084/m9.figshare.14419793.v1
title: Supplementary Material for: Efficacy of Individualized Homeopathic Medicines in the Treatment of Atopic Dermatitis in Adults: A Double-Blind, Randomized, Placebo-Controlled, Preliminary Trial

description: <b><i>Introduction:</i></b> Individualized homeopathy (IH) in atopic dermatitis (AD) remained under-researched. <b><i>Objective:</i></b> We aimed at evaluating efficacy of IH in AD. <b><i>Methods:</i></b> A double-blind, randomized, placebo-controlled, short-term, preliminary trial was conducted in an Indian homeopathy hospital. Patients were randomized to either IH (<i>n</i> = 30) or identical-looking placebo (<i>n</i> = 30) using computerized randomization and allocation. Outcomes were patient-oriented scoring of AD (PO-SCORAD; primary end point), Dermatological Life Quality Index (DLQI) score, and AD burden score for adults (ADBSA; secondary end points), measured monthly for 3 months. An intention-to-treat sample was analyzed after adjusting baseline differences. <b><i>Results:</i></b> On PO-SCORAD, improvement was higher in IH against placebo, but nonsignificant statistically (<i>p</i><sub>month 1</sub> = 0.433, <i>p</i><sub>month 2</sub> = 0.442, <i>p</i><sub>month 3</sub> = 0.229). Secondary outcomes were also nonsignificant – both DLQI and ADBSA (<i>p</i> &gt; 0.05). Four adverse events (diarrhea, injury, common cold) were recorded. <b><i>Conclusions:</i></b> There was a small, but nonsignificant direction of effect towards homeopathy, which renders the trial inconclusive. A properly powered robust trial is indicated.
DOI: 10.6084/m9.figshare.7416638.v1
title: Reptile_shapefiles

description: Geographical ranges (shapefiles) for 85 reptile species.
DOI: 10.15468/dl.uthzdu
title: Occurrence Download

description: A dataset containing 8660 species occurrences available in GBIF matching the query:
{
 "and" : [
 "HasGeospatialIssue is false",
 "HasCoordinate is true",
 "OccurrenceStatus is Present",
 {
 "not" : {
 "BasisOfRecord" : [
 "is one of (Observation, Human Observation, Machine Observation, Living Specimen)"
 ]
 }
 },
 "TaxonKey is Euplexia lucipara (Linnaeus, 1758)"
 ]
}

 The dataset includes 8660 records from 86 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0009670-250426092105405/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.