cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.7898966.v1
title: Combination therapy of orally administered glycyrrhizin and UVB improved active-stage generalized vitiligo

description: Glycyrrhizin has been used clinically for several years due to its beneficial effect on immunoglobulin E (IgE)-induced allergic diseases, alopecia areata and psoriasis. In this study, glycyrrhizin, ultraviolet B light (UVB) or a combination of both were used to treat active-stage generalized vitiligo. One hundred and forty-four patients between the ages of 3 and 48 years were divided into three groups: group A received oral compound glycyrrhizin (OCG); group B received UVB applications twice weekly, and group C received OCG+UVB. Follow-ups were performed at 2, 4, and 6 months after the treatment was initiated. The Vitiligo Area Scoring Index (VASI) and the Vitiligo Disease Activity (VIDA) instrument were used to assess the affected body surface, at each follow-up. Results showed that 77.1, 75.0 and 87.5% in groups A, B and C, respectively, presented repigmentation of lesions. Responsiveness to therapy seemed to be associated with lesion location and patient compliance. Adverse events were limited and transient. This study showed that, although the three treatment protocols had positive results, OCG and UVB combination therapy was the most effective and led to improvement in disease stage from active to stable.
DOI: 10.6084/m9.figshare.7898942
title: Central release of nitric oxide mediates antinociception induced by aerobic exercise

description: Nitric oxide (NO) is a soluble gas that participates in important functions of the central nervous system, such as cognitive function, maintenance of synaptic plasticity for the control of sleep, appetite, body temperature, neurosecretion, and antinociception. Furthermore, during exercise large amounts of NO are released that contribute to maintaining body homeostasis. Besides NO production, physical exercise has been shown to induce antinociception. Thus, the present study aimed to investigate the central involvement of NO in exercise-induced antinociception. In both mechanical and thermal nociceptive tests, central [intrathecal (it) and intracerebroventricular (icv)] pretreatment with inhibitors of the NO/cGMP/KATP pathway (L-NOArg, ODQ, and glybenclamide) prevented the antinociceptive effect induced by aerobic exercise (AE). Furthermore, pretreatment (it, icv) with specific NO synthase inhibitors (L-NIO, aminoguanidine, and L-NPA) also prevented this effect. Supporting the hypothesis of the central involvement of NO in exercise-induced antinociception, nitrite levels in the cerebrospinal fluid increased immediately after AE. Therefore, the present study suggests that, during exercise, the NO released centrally induced antinociception.
DOI: 10.6084/m9.figshare.7898945
title: Prosthesis-Patient Mismatch Negatively Affects Outcomes after Mitral Valve Replacement: Meta-Analysis of 10,239 Patients

description: Abstract Objective: This study sought to evaluate the impact of prosthesis-patient mismatch on the risk of perioperative and long-term mortality after mitral valve replacement. Methods: Databases were researched for studies published until December 2018. Main outcomes of interest were perioperative and 10-year mortality and echocardiographic parameters. Results: The research yielded 2,985 studies for inclusion. Of these, 16 articles were analyzed, and their data extracted. The total number of patients included was 10,239, who underwent mitral valve replacement. The incidence of prosthesis-patient mismatch after mitral valve replacement was 53.7% (5,499 with prosthesis-patient mismatch and 4,740 without prosthesis-patient mismatch). Perioperative (OR 1.519; 95%CI 1.194-1.931, P&lt;0.001) and 10-year (OR 1.515; 95%CI 1.280-1.795, P&lt;0.001) mortality was increased in patients with prosthesis-patient mismatch. Patients with prosthesis-patient mismatch after mitral valve replacement had higher systolic pulmonary artery pressure and transprosthethic gradient and lower indexed effective orifice area and left ventricle ejection fraction. Conclusion: Prosthesis-patient mismatch increases perioperative and long-term mortality. Prosthesis-patient mismatch is also associated with pulmonary hypertension and depressed left ventricle systolic function. The findings of this study support the implementation of surgical strategies to prevent prosthesis-patient mismatch in order to decrease mortality rates.
DOI: 10.6084/m9.figshare.7898948
title: MORPHOLOGICAL, ANATOMICAL AND PHYSIOLOGICAL CHARACTERISTICS OF Acrocarpus fraxinifolius WIGHT & ARN SEEDLINGS ACCORDING TO CONTAINERS AND FERTILIZATION

description: ABSTRACT The production of quality seedlings coupled with the correct choice of fertilizer doses/sources and the container type are essential in the planting of forest species. Thus, the objective of this study was to evaluate the relationship between morphological, physiological and anatomical characteristics and container volume with different fertilizations on Acrocarpus fraxinifolius seeds seedlings. The experiment was conducted in a 2 x 8 factorial scheme (2 volumes of containers and 8 fertilizations), tested in polypropylene tubes of 50 and 110 cm³ and according to different fertilizations: control without fertilization; 4 increasing doses of Osmocote® Plus: 3, 5, 7, 9 kg.per.m³ of substrate, respectively; and 3 split mineral fertilizers with coverings. It was possible to note that the tube with the greatest volume of 110 cm³ presented the best results regarding the morphological characteristics, however, when analyzing the physiological variables it was clear that the 50 cm³ tubes present similar results to those of larger volume when well fertilized. Split fertilization presented better results than slow-release fertilization, and 50 cm³ tubes were more sensitive to fertilization due to the lower volume. Thus, the use of 50 cm³ tubes with fertilization is recommended for producing A. fraxinifolius seedlings, due to presenting physiological quality and economy of inputs in nursery production, transportation and planting.
DOI: 10.6084/m9.figshare.7898951
title: Immunohistochemical expressionof sodium-dependent glucose transporter - 2 (SGLT-2) in clear cell renal carcinoma: possible prognostic implications

description: ABSTRACT Purpose: Glucose is a major energy resource for tumor cell survival and growth, and its influx into cells is mainly carried out by facilitative glucose transporters (GLUTs). Sodium - dependent glucose transporters (SGLTs) have been highlighted as playing important roles in diabetic treatment. However, their potential roles in cancer remain unclear. We examined expression patterns of SGLTs in tumor tissues together with conventional pathological variables to determine prognostic significance in patients with renal cell carcinoma (RCC). Materials and Methods: Nephrectomy specimens were obtained from 68 patients. GLUT - 1, - 2 and SGLT - 1, - 2 expression in tumor and adjacent normal tissues were analyzed by immunohistochemical staining, and intensity was quantified using an image analyzer. Results: The four glucose transporters evaluated were broadly distributed in tumor tissues as well as throughout the normal parenchyma. There was no significant correlation between transporter expression and conventional pathological variables. However, increased SGLT - 2 expression was significantly associated with shorter overall survival (p &lt; 0.01), regardless of metastatic status. Conclusions: We propose possible prognostic significance of SGLT - 2 expression in human RCC. Given that glucose is a major energy resource for tumor cells and that glucose transport is largely mediated by SGLT, SGLT - 2 may serve as a possible therapeutic target in RCC.
DOI: 10.6084/m9.figshare.7898954.v1
title: Physical exercise prevents motor disorders and striatal oxidative imbalance after cerebral ischemia-reperfusion

description: Stroke is the third most common cause of death worldwide, and most stroke survivors present some functional impairment. We assessed the striatal oxidative balance and motor alterations resulting from stroke in a rat model to investigate the neuroprotective role of physical exercise. Forty male Wistar rats were assigned to 4 groups: a) control, b) ischemia, c) physical exercise, and d) physical exercise and ischemia. Physical exercise was conducted using a treadmill for 8 weeks. Ischemia-reperfusion surgery involved transient bilateral occlusion of the common carotid arteries for 30 min. Neuromotor performance (open-field and rotarod performance tests) and pain sensitivity were evaluated beginning at 24 h after the surgery. Rats were euthanized and the corpora striata was removed for assay of reactive oxygen species, lipoperoxidation activity, and antioxidant markers. Ischemia-reperfusion caused changes in motor activity. The ischemia-induced alterations observed in the open-field test were fully reversed, and those observed in the rotarod test were partially reversed, by physical exercise. Pain sensitivity was similar among all groups. Levels of reactive oxygen species and lipoperoxidation increased after ischemia; physical exercise decreased reactive oxygen species levels. None of the treatments altered the levels of antioxidant markers. In summary, ischemia-reperfusion resulted in motor impairment and altered striatal oxidative balance in this animal model, but those changes were moderated by physical exercise.
DOI: 10.6084/m9.figshare.7898951.v1
title: Immunohistochemical expressionof sodium-dependent glucose transporter - 2 (SGLT-2) in clear cell renal carcinoma: possible prognostic implications

description: ABSTRACT Purpose: Glucose is a major energy resource for tumor cell survival and growth, and its influx into cells is mainly carried out by facilitative glucose transporters (GLUTs). Sodium - dependent glucose transporters (SGLTs) have been highlighted as playing important roles in diabetic treatment. However, their potential roles in cancer remain unclear. We examined expression patterns of SGLTs in tumor tissues together with conventional pathological variables to determine prognostic significance in patients with renal cell carcinoma (RCC). Materials and Methods: Nephrectomy specimens were obtained from 68 patients. GLUT - 1, - 2 and SGLT - 1, - 2 expression in tumor and adjacent normal tissues were analyzed by immunohistochemical staining, and intensity was quantified using an image analyzer. Results: The four glucose transporters evaluated were broadly distributed in tumor tissues as well as throughout the normal parenchyma. There was no significant correlation between transporter expression and conventional pathological variables. However, increased SGLT - 2 expression was significantly associated with shorter overall survival (p &lt; 0.01), regardless of metastatic status. Conclusions: We propose possible prognostic significance of SGLT - 2 expression in human RCC. Given that glucose is a major energy resource for tumor cells and that glucose transport is largely mediated by SGLT, SGLT - 2 may serve as a possible therapeutic target in RCC.
DOI: 10.6084/m9.figshare.7898939
title: Crescent Shape Microstrip Antenna for Dual polarized Multi-band Response

description: Abstract Novel design of multi-band Crescent shape microstrip antenna is proposed. Modifications in equivalent circular patch yields new resonant modes nearer to the TM11 and TM21 modes in circular patch that gives four band frequency response showing dual polarizations. Proposed design gives 1 to 1.5% of bandwidth at each frequency with broadside radiation pattern. The resonance frequency equation by defining the resonant length at each mode in the Crescent shape patch, is proposed. The frequency calculated using the same agrees closely with simulated result. The air suspended design of crescent shape patch is presented which yields co-polar peak gain of above 1.5 dBi.
DOI: 10.6084/m9.figshare.7898942.v1
title: Central release of nitric oxide mediates antinociception induced by aerobic exercise

description: Nitric oxide (NO) is a soluble gas that participates in important functions of the central nervous system, such as cognitive function, maintenance of synaptic plasticity for the control of sleep, appetite, body temperature, neurosecretion, and antinociception. Furthermore, during exercise large amounts of NO are released that contribute to maintaining body homeostasis. Besides NO production, physical exercise has been shown to induce antinociception. Thus, the present study aimed to investigate the central involvement of NO in exercise-induced antinociception. In both mechanical and thermal nociceptive tests, central [intrathecal (it) and intracerebroventricular (icv)] pretreatment with inhibitors of the NO/cGMP/KATP pathway (L-NOArg, ODQ, and glybenclamide) prevented the antinociceptive effect induced by aerobic exercise (AE). Furthermore, pretreatment (it, icv) with specific NO synthase inhibitors (L-NIO, aminoguanidine, and L-NPA) also prevented this effect. Supporting the hypothesis of the central involvement of NO in exercise-induced antinociception, nitrite levels in the cerebrospinal fluid increased immediately after AE. Therefore, the present study suggests that, during exercise, the NO released centrally induced antinociception.
DOI: 10.6084/m9.figshare.7898945.v1
title: Prosthesis-Patient Mismatch Negatively Affects Outcomes after Mitral Valve Replacement: Meta-Analysis of 10,239 Patients

description: Abstract Objective: This study sought to evaluate the impact of prosthesis-patient mismatch on the risk of perioperative and long-term mortality after mitral valve replacement. Methods: Databases were researched for studies published until December 2018. Main outcomes of interest were perioperative and 10-year mortality and echocardiographic parameters. Results: The research yielded 2,985 studies for inclusion. Of these, 16 articles were analyzed, and their data extracted. The total number of patients included was 10,239, who underwent mitral valve replacement. The incidence of prosthesis-patient mismatch after mitral valve replacement was 53.7% (5,499 with prosthesis-patient mismatch and 4,740 without prosthesis-patient mismatch). Perioperative (OR 1.519; 95%CI 1.194-1.931, P&lt;0.001) and 10-year (OR 1.515; 95%CI 1.280-1.795, P&lt;0.001) mortality was increased in patients with prosthesis-patient mismatch. Patients with prosthesis-patient mismatch after mitral valve replacement had higher systolic pulmonary artery pressure and transprosthethic gradient and lower indexed effective orifice area and left ventricle ejection fraction. Conclusion: Prosthesis-patient mismatch increases perioperative and long-term mortality. Prosthesis-patient mismatch is also associated with pulmonary hypertension and depressed left ventricle systolic function. The findings of this study support the implementation of surgical strategies to prevent prosthesis-patient mismatch in order to decrease mortality rates.
DOI: 10.6084/m9.figshare.7898948.v1
title: MORPHOLOGICAL, ANATOMICAL AND PHYSIOLOGICAL CHARACTERISTICS OF Acrocarpus fraxinifolius WIGHT & ARN SEEDLINGS ACCORDING TO CONTAINERS AND FERTILIZATION

description: ABSTRACT The production of quality seedlings coupled with the correct choice of fertilizer doses/sources and the container type are essential in the planting of forest species. Thus, the objective of this study was to evaluate the relationship between morphological, physiological and anatomical characteristics and container volume with different fertilizations on Acrocarpus fraxinifolius seeds seedlings. The experiment was conducted in a 2 x 8 factorial scheme (2 volumes of containers and 8 fertilizations), tested in polypropylene tubes of 50 and 110 cm³ and according to different fertilizations: control without fertilization; 4 increasing doses of Osmocote® Plus: 3, 5, 7, 9 kg.per.m³ of substrate, respectively; and 3 split mineral fertilizers with coverings. It was possible to note that the tube with the greatest volume of 110 cm³ presented the best results regarding the morphological characteristics, however, when analyzing the physiological variables it was clear that the 50 cm³ tubes present similar results to those of larger volume when well fertilized. Split fertilization presented better results than slow-release fertilization, and 50 cm³ tubes were more sensitive to fertilization due to the lower volume. Thus, the use of 50 cm³ tubes with fertilization is recommended for producing A. fraxinifolius seedlings, due to presenting physiological quality and economy of inputs in nursery production, transportation and planting.
DOI: 10.6084/m9.figshare.7898924
title: Role of chemokines in promoting instability of coronary atherosclerotic plaques and the underlying molecular mechanism

description: Our aim was to investigate the role of chemokines in promoting instability of coronary atherosclerotic plaques and the underlying molecular mechanism. Coronary angiography and intravascular ultrasound (IVUS) were performed in 60 stable angina pectoris (SAP) patients and 60 unstable angina pectoris (UAP) patients. The chemotactic activity of monocytes in the 2 groups of patients was examined in Transwell chambers. High-sensitivity C-reactive protein (hs-CRP), monocyte chemoattractant protein-1 (MCP-1), regulated on activation in normal T-cell expressed and secreted (RANTES), and fractalkine in serum were examined with ELISA kits, and expression of MCP-1, RANTES, and fractalkine mRNA was examined with real-time PCR. In the SAP group, 92 plaques were detected with IVUS. In the UAP group, 96 plaques were detected with IVUS. The plaques in the UAP group were mainly lipid 51.04% (49/96) and the plaques in the SAP group were mainly fibrous 52.17% (48/92). Compared with the SAP group, the plaque burden and vascular remodeling index in the UAP group were significantly greater than in the SAP group (P&lt;0.01). Chemotactic activity and the number of mobile monocytes in the UAP group were significantly greater than in the SAP group (P&lt;0.01). Concentrations of hs-CRP, MCP-1, RANTES, and fractalkine in the serum of the UAP group were significantly higher than in the serum of the SAP group (P&lt;0.05 or P&lt;0.01), and expression of MCP-1, RANTES, and fractalkine mRNA was significantly higher than in the SAP group (P&lt;0.05). MCP-1, RANTES, and fractalkine probably promote instability of coronary atherosclerotic plaque.
DOI: 10.6084/m9.figshare.7898927
title: Puerarin protects against damage to spatial learning and memory ability in mice with chronic alcohol poisoning

description: We evaluated the effect of puerarin on spatial learning and memory ability of mice with chronic alcohol poisoning. A total of 30 male C57BL/6 mice were randomly divided into model, puerarin, and control groups (n=10 each). The model group received 60% (v/v) ethanol by intragastric administration followed by intraperitoneal injection of normal saline 30 min later. The puerarin group received intragastric 60% ethanol followed by intraperitoneal puerarin 30 min later, and the control group received intragastric saline followed by intraperitoneal saline. Six weeks after treatment, the Morris water maze and Tru Scan behavioral tests and immunofluorescence staining of cerebral cortex and hippocampal neurons (by Neu-N) and microglia (by Ib1) were conducted. Glutamic acid (Glu) and gamma amino butyric acid (GABA) in the cortex and hippocampus were assayed by high-performance liquid chromatography (HPLC), and tumor necrosis factor (TNF)-α and interleukin (IL)-1β were determined by ELISA. Compared with mice in the control group, escape latency and distance were prolonged, and spontaneous movement distance was shortened (P&lt;0.05) by puerarin. The number of microglia was increased in both the cortex and hippocampal dentate gyrus (P&lt;0.01), and neurons were reduced only in the hippocampal dentate gyrus (P&lt;0.01) in puerarin-treated mice. In the model group, Glu and GABA levels decreased (P&lt;0.05), and Glu/GABA, TNF-α, and IL-1β increased (P&lt;0.01) with puerarin treatment, returning to near normal levels. In conclusion, puerarin protected against the effects of chronic alcohol poisoning on spatial learning and memory ability primarily because of anti-inflammatory activity and regulation of the balance of Glu and GABA.
DOI: 10.6084/m9.figshare.7898933
title: High levels of LDL-C combined with low levels of HDL-C further increase platelet activation in hypercholesterolemic patients

description: High levels of low-density lipoprotein cholesterol (LDL-C) enhance platelet activation, whereas high levels of high-density lipoprotein cholesterol (HDL-C) exert a cardioprotective effect. However, the effects on platelet activation of high levels of LDL-C combined with low levels of HDL-C (HLC) have not yet been reported. We aimed to evaluate the platelet activation marker of HLC patients and investigate the antiplatelet effect of atorvastatin on this population. Forty-eight patients with high levels of LDL-C were enrolled. Among these, 23 had HLC and the other 25 had high levels of LDL-C combined with normal levels of HDL-C (HNC). A total of 35 normocholesterolemic (NOMC) volunteers were included as controls. Whole blood flow cytometry and platelet aggregation measurements were performed on all participants to detect the following platelet activation markers: CD62p (P-selectin), PAC-1 (GPIIb/IIIa), and maximal platelet aggregation (MPAG). A daily dose of 20 mg atorvastatin was administered to patients with high levels of LDL-C, and the above assessments were obtained at baseline and after 1 and 2 months of treatment. The expression of platelets CD62p and PAC-1 was increased in HNC patients compared to NOMC volunteers (P&lt;0.01 and P&lt;0.05). Furthermore, the surface expression of platelets CD62p and PAC-1 was greater among HLC patients than among HNC patients (P&lt;0.01 and P&lt;0.05). Although the expression of CD62p and PAC-1 decreased significantly after atorvastatin treatment, it remained higher in the HLC group than in the HNC group (P&lt;0.05 and P=0.116). The reduction of HDL-C further increased platelet activation in patients with high levels of LDL-C. Platelet activation remained higher among HLC patients regardless of atorvastatin treatment.