cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.21087472
title: New possibilities for chromoblastomycosis and phaeohyphomycosis treatment: identification of two compounds from the MMV Pathogen Box® that present synergism with itraconazole

description: BACKGROUND Black fungi of the Herpotrichiellaceae family are agents of chromoblastomycosis and phaeohyphomycosis. There are few therapeutic options for these infections and it is common to associate antifungal drugs in their treatment. OBJECTIVES To investigate the Medicines for Malaria Venture (MMV) Pathogen Box® for possible compounds presenting synergism with antifungal drugs used to treat black fungal infections. METHODS An initial screening of the Pathogen Box® compounds was performed in combination with itraconazole or terbinafine at sub-inhibitory concentrations against Fonsecaea pedrosoi. Hits were further tested against eight Herpotrichiellaceae using the checkerboard method. FINDINGS No synergism was observed with terbinafine. MMV687273 (SQ109) and MMV688415 showed synergism with itraconazole against F. pedrosoi. Synergism of these compounds was confirmed with some black fungi by the checkerboard method. SQ109 and itraconazole presented synergism for Exophiala dermatitidis, F. pedrosoi, F. monophora and F. nubica, with fungicidal activity for F. pedrosoi and F. monophora. MMV688415 presented synergism with itraconazole only for F. pedrosoi, with fungicidal activity. The synergic compounds had high selectivity index values when combined with itraconazole. MAIN CONCLUSIONS These compounds in combination, particularly SQ109, are promising candidates to treat Fonsecaea spp. and E. dermatitidis infections, which account for most cases of chromoblastomycosis and phaeohyphomycosis.
DOI: 10.6084/m9.figshare.21087472.v1
title: New possibilities for chromoblastomycosis and phaeohyphomycosis treatment: identification of two compounds from the MMV Pathogen Box® that present synergism with itraconazole

description: BACKGROUND Black fungi of the Herpotrichiellaceae family are agents of chromoblastomycosis and phaeohyphomycosis. There are few therapeutic options for these infections and it is common to associate antifungal drugs in their treatment. OBJECTIVES To investigate the Medicines for Malaria Venture (MMV) Pathogen Box® for possible compounds presenting synergism with antifungal drugs used to treat black fungal infections. METHODS An initial screening of the Pathogen Box® compounds was performed in combination with itraconazole or terbinafine at sub-inhibitory concentrations against Fonsecaea pedrosoi. Hits were further tested against eight Herpotrichiellaceae using the checkerboard method. FINDINGS No synergism was observed with terbinafine. MMV687273 (SQ109) and MMV688415 showed synergism with itraconazole against F. pedrosoi. Synergism of these compounds was confirmed with some black fungi by the checkerboard method. SQ109 and itraconazole presented synergism for Exophiala dermatitidis, F. pedrosoi, F. monophora and F. nubica, with fungicidal activity for F. pedrosoi and F. monophora. MMV688415 presented synergism with itraconazole only for F. pedrosoi, with fungicidal activity. The synergic compounds had high selectivity index values when combined with itraconazole. MAIN CONCLUSIONS These compounds in combination, particularly SQ109, are promising candidates to treat Fonsecaea spp. and E. dermatitidis infections, which account for most cases of chromoblastomycosis and phaeohyphomycosis.
DOI: 10.34740/kaggle/ds/2474881
title: Helmet Wearing Persons
DOI: 10.6084/m9.figshare.21087475
title: The role of topographic-derived hydrological variables in explaining plant species distributions in Amazonia

description: ABSTRACT In Amazonian terra-firme non inundated forests, local floristic composition and species occurrence are explained by water availability as determined by topographic conditions. Topographic complexity can render these conditions quite variable across the landscape and the effects on plant ecological responses are difficult to document. We used a set of topographically defined hydrological metrics to evaluate community composition and single-species responses of four plant groups [pteridophytes (ferns and lycophytes), Melastomataceae, palms (Arecaceae) and Zingiberales] to topographic conditions in the middle Juruá River region, in western Brazilian Amazonia. The area spans two geological formations (Içá and Solimões) with contrasting topography. River terraces are also found along the main rivers in the area. Local topographic conditions were approximated by height above the nearest drainage (HAND), slope, and Strahler´s drainage order, all obtained from a SRTM digital elevation model (DEM). Data were analyzed using linear and generalized linear mixed models and regression trees. HAND was most successful in explaining floristic composition for all plant groups, except for Melastomataceae, and was more important in the hilly Içá formation than in the Solimões. Individual occurrences of 57% species were predicted by at least one of the topographic variables, suggesting a marked habitat specialization along topographic gradients. For these species, response models using SRTM-DEM-derived variables gave similar results than models using field-measured topography only. Our results suggest that topographical variables estimated from remote sensing can be used to predict local variation in the structure of plant communities in tropical forests.
DOI: 10.6084/m9.figshare.21087475.v1
title: The role of topographic-derived hydrological variables in explaining plant species distributions in Amazonia

description: ABSTRACT In Amazonian terra-firme non inundated forests, local floristic composition and species occurrence are explained by water availability as determined by topographic conditions. Topographic complexity can render these conditions quite variable across the landscape and the effects on plant ecological responses are difficult to document. We used a set of topographically defined hydrological metrics to evaluate community composition and single-species responses of four plant groups [pteridophytes (ferns and lycophytes), Melastomataceae, palms (Arecaceae) and Zingiberales] to topographic conditions in the middle Juruá River region, in western Brazilian Amazonia. The area spans two geological formations (Içá and Solimões) with contrasting topography. River terraces are also found along the main rivers in the area. Local topographic conditions were approximated by height above the nearest drainage (HAND), slope, and Strahler´s drainage order, all obtained from a SRTM digital elevation model (DEM). Data were analyzed using linear and generalized linear mixed models and regression trees. HAND was most successful in explaining floristic composition for all plant groups, except for Melastomataceae, and was more important in the hilly Içá formation than in the Solimões. Individual occurrences of 57% species were predicted by at least one of the topographic variables, suggesting a marked habitat specialization along topographic gradients. For these species, response models using SRTM-DEM-derived variables gave similar results than models using field-measured topography only. Our results suggest that topographical variables estimated from remote sensing can be used to predict local variation in the structure of plant communities in tropical forests.
DOI: 10.6084/m9.figshare.21087478
title: Acceptance of Low-Sodium Hospital Diet by Cardiac Patients: A Randomized Controlled Crossover Trial

description: Abstract Background Cardiovascular diseases are the major cause of hospitalization. Dietary salt restriction is indicated as part of clinical treatment, however, it is not always well accepted by the patients, resulting in low food intake and malnutrition. Objective To compare acceptance of a low-sodium diet cooked with salt with a standard low-sodium diet in cardiac inpatients. Methods A randomized controlled crossover trial in patients with low-sodium diet prescriptions (Clinical Trials NCT03481322). Patients were given a control standard low sodium diet (cooked without salt; salt [2g per meal] added by the patient at the time of consumption) on one day and on the next day patients were given the intervention diet – a low sodium diet cooked with salt (2 grams of salt, divided between preparations). Dietary acceptance was evaluated by weighing leftover food and calculating intake. A questionnaire was used to verify reasons that influenced acceptance. For data analysis, parametric data are presented as mean and standard deviation, Student’s t test was used to compare means, with significance defined as p&lt;0.05. Results Sixty-four patients were evaluated, with a mean age of 66 ± 11.3 years; 64% were male. There were no differences in percentage acceptance between the standard low-sodium diet and the low-sodium diet cooked with salt at lunch (p= 0.876) or at dinner (p= 0.255). Around 80% of what was offered at each meal was consumed by the patients, with no significant difference between groups. Conclusions The low-sodium diet cooked with salt was well accepted, but there was no difference when compared with the standard low-sodium diet, which also had adequate acceptance.
DOI: 10.6084/m9.figshare.21087478.v1
title: Acceptance of Low-Sodium Hospital Diet by Cardiac Patients: A Randomized Controlled Crossover Trial

description: Abstract Background Cardiovascular diseases are the major cause of hospitalization. Dietary salt restriction is indicated as part of clinical treatment, however, it is not always well accepted by the patients, resulting in low food intake and malnutrition. Objective To compare acceptance of a low-sodium diet cooked with salt with a standard low-sodium diet in cardiac inpatients. Methods A randomized controlled crossover trial in patients with low-sodium diet prescriptions (Clinical Trials NCT03481322). Patients were given a control standard low sodium diet (cooked without salt; salt [2g per meal] added by the patient at the time of consumption) on one day and on the next day patients were given the intervention diet – a low sodium diet cooked with salt (2 grams of salt, divided between preparations). Dietary acceptance was evaluated by weighing leftover food and calculating intake. A questionnaire was used to verify reasons that influenced acceptance. For data analysis, parametric data are presented as mean and standard deviation, Student’s t test was used to compare means, with significance defined as p&lt;0.05. Results Sixty-four patients were evaluated, with a mean age of 66 ± 11.3 years; 64% were male. There were no differences in percentage acceptance between the standard low-sodium diet and the low-sodium diet cooked with salt at lunch (p= 0.876) or at dinner (p= 0.255). Around 80% of what was offered at each meal was consumed by the patients, with no significant difference between groups. Conclusions The low-sodium diet cooked with salt was well accepted, but there was no difference when compared with the standard low-sodium diet, which also had adequate acceptance.
DOI: 10.6084/m9.figshare.21086572
title: Main datasets for Shen et. al., 2022

description: Main datasets for Shen et. al., 2022
DOI: 10.6084/m9.figshare.21087484
title: Pharmaceutical policies for gaining access to high-priced medicines: a comparative analysis between England and Brazil

description: ABSTRACT Although the National Health Service (NHS) and the Unified Health System (SUS) are systems with similar universal principles, they can show different political measure patterns in the pharmaceutical field. This paper aimed to provide a comparative analysis of pharmaceutical policies highlighting strategies to guarantee access and sustainability to High-Price Medicines (HPMs) in Brazil and England. We performed an integrative literature review in electronic databases, supplemented by grey literature searched on governmental platforms (laws, decrees, ordinances, and resolutions). A total of Forty-seven articles and seven policies were selected and categorized for analysis. The results showed that both countries apply distinct policies to ensure access to HPMs, among them, policies to define price and reimbursement and actions to regulate the use inside the system. Also, these countries apply distinct policies to their sustainability as local partnerships for product development in Brazil and confidential managed agreements with multinational industries in the England. In conclusion, despite similarities in principles, these countries have been proposing and applying distinct pharmaceutical policies to maintain access and ensure the sustainability of their health systems.
DOI: 10.6084/m9.figshare.21087484.v1
title: Pharmaceutical policies for gaining access to high-priced medicines: a comparative analysis between England and Brazil

description: ABSTRACT Although the National Health Service (NHS) and the Unified Health System (SUS) are systems with similar universal principles, they can show different political measure patterns in the pharmaceutical field. This paper aimed to provide a comparative analysis of pharmaceutical policies highlighting strategies to guarantee access and sustainability to High-Price Medicines (HPMs) in Brazil and England. We performed an integrative literature review in electronic databases, supplemented by grey literature searched on governmental platforms (laws, decrees, ordinances, and resolutions). A total of Forty-seven articles and seven policies were selected and categorized for analysis. The results showed that both countries apply distinct policies to ensure access to HPMs, among them, policies to define price and reimbursement and actions to regulate the use inside the system. Also, these countries apply distinct policies to their sustainability as local partnerships for product development in Brazil and confidential managed agreements with multinational industries in the England. In conclusion, despite similarities in principles, these countries have been proposing and applying distinct pharmaceutical policies to maintain access and ensure the sustainability of their health systems.
DOI: 10.6084/m9.figshare.21086572.v1
title: fb_burst.sql

description: Database to replicate Figure 5 in Shen et. al., 2022.
DOI: 10.6084/m9.figshare.20969904
title: Helminth’s assemblage of a small frog in the Brazilian semiarid: parasite-host-environment relationships

description: ABSTRACT. Parasite infections may contingency different aspects of the hosts’ lives, and are usually expected to directly or indirectly compromise host reproduction. However, although amphibians have historically been study models in parasite ecology, the effects of parasitism on amphibians’ reproduction remain unknown. Thus, we investigated how the parasite load varies as a function of climatic seasonality (rainy and dry season) and intrinsic host characteristics (size and sex), as well as the relationship between parasite load and reproductive investment in males and females of a small frog (Pseudopaludicola pocoto Magalhães, Loebmann, Kokubum, Haddad & Garda, 2014) in the Brazilian semiarid region. The parasitological parameters of the studied population were not influenced by the season of the year or by the hosts’ body size, but females of P. pocoto had a higher prevalence and intensity of infection than males. The number of oocytes and the volume of the testes were not related to the parasite load, revealing that the parasitism did not negatively impact the gonadal investment in P. pocoto. Our findings suggest that short-lived species, such as the tiny Pseudopaludicola species, have a high reproductive investment independent of their parasitic interactions. In addition, this should be true mainly in those species that live in seasonally dry environments, such as P. pocoto, in which reproduction is even more constrained by the shortened and unpredictable rainy period.
DOI: 10.6084/m9.figshare.20969904.v1
title: Helminth’s assemblage of a small frog in the Brazilian semiarid: parasite-host-environment relationships

description: ABSTRACT. Parasite infections may contingency different aspects of the hosts’ lives, and are usually expected to directly or indirectly compromise host reproduction. However, although amphibians have historically been study models in parasite ecology, the effects of parasitism on amphibians’ reproduction remain unknown. Thus, we investigated how the parasite load varies as a function of climatic seasonality (rainy and dry season) and intrinsic host characteristics (size and sex), as well as the relationship between parasite load and reproductive investment in males and females of a small frog (Pseudopaludicola pocoto Magalhães, Loebmann, Kokubum, Haddad & Garda, 2014) in the Brazilian semiarid region. The parasitological parameters of the studied population were not influenced by the season of the year or by the hosts’ body size, but females of P. pocoto had a higher prevalence and intensity of infection than males. The number of oocytes and the volume of the testes were not related to the parasite load, revealing that the parasitism did not negatively impact the gonadal investment in P. pocoto. Our findings suggest that short-lived species, such as the tiny Pseudopaludicola species, have a high reproductive investment independent of their parasitic interactions. In addition, this should be true mainly in those species that live in seasonally dry environments, such as P. pocoto, in which reproduction is even more constrained by the shortened and unpredictable rainy period.
DOI: 10.6084/m9.figshare.12094689.v1
title: Medical Behavior in Cardiorespiratory Arrest before and After Simulation Based on Advanced Cardiac Life Support (ACLS) Course

description: Abstract Background: The Advanced Cardiac Life Support (ACLS) course is designed to teach cardiovascular emergency, aiming to promote a harmonious and synchronized work of the entire hospital team, making the multidisciplinary job more effective in the execution of cardiopulmonary resuscitation (CPR). Objective: To compare the effectiveness of CPR performed between physicians trained on ACLS and non-trained physicians. Methods: A questionnaire was applied to physicians working at the emergency room of hospitals in Curitiba, state of Paraná, whose resolution required theoretical and practical knowledge about CPR. For analysis, descriptive statistics and Fisher's association analysis were used, and the medians of the groups were evaluated by Mann-Whitney/Kruskal-Wallis with significance of 5%. Results: Thirty-four physicians were volunteers, of whom 20 had taken the ACLS course (Group A) and 14 had not (Group B). The trained physicians obtained the highest median (4.00 vs. 3.00, p = 0.06) of correct answers. Group A scored at least 3 of the 5 questions in the questionnaire, showing better performance than Group B (OR = 6.75, 95% CI, 1.1 &lt; OR &lt; 41.0, p = 0.04). The year of the course did not significantly change the performance in the questionnaire. Conclusion: It is suggested that the ACLS course was effective in qualifying physicians to handle situations of cardiorespiratory arrest properly, which was reproduced by the better performance in the resolution of the questionnaire. It is believed that when the sample of volunteers is increased, the trends found materialize the other hypotheses proposed.
DOI: 10.6084/m9.figshare.12094689
title: Medical Behavior in Cardiorespiratory Arrest before and After Simulation Based on Advanced Cardiac Life Support (ACLS) Course

description: Abstract Background: The Advanced Cardiac Life Support (ACLS) course is designed to teach cardiovascular emergency, aiming to promote a harmonious and synchronized work of the entire hospital team, making the multidisciplinary job more effective in the execution of cardiopulmonary resuscitation (CPR). Objective: To compare the effectiveness of CPR performed between physicians trained on ACLS and non-trained physicians. Methods: A questionnaire was applied to physicians working at the emergency room of hospitals in Curitiba, state of Paraná, whose resolution required theoretical and practical knowledge about CPR. For analysis, descriptive statistics and Fisher's association analysis were used, and the medians of the groups were evaluated by Mann-Whitney/Kruskal-Wallis with significance of 5%. Results: Thirty-four physicians were volunteers, of whom 20 had taken the ACLS course (Group A) and 14 had not (Group B). The trained physicians obtained the highest median (4.00 vs. 3.00, p = 0.06) of correct answers. Group A scored at least 3 of the 5 questions in the questionnaire, showing better performance than Group B (OR = 6.75, 95% CI, 1.1 &lt; OR &lt; 41.0, p = 0.04). The year of the course did not significantly change the performance in the questionnaire. Conclusion: It is suggested that the ACLS course was effective in qualifying physicians to handle situations of cardiorespiratory arrest properly, which was reproduced by the better performance in the resolution of the questionnaire. It is believed that when the sample of volunteers is increased, the trends found materialize the other hypotheses proposed.
DOI: 10.6084/m9.figshare.21087485
title: New insights into Canis familiaris papillomaviruses genetics and biology: Is the genetic characterization of CPV types and their variants an important clinical issue?

description: Abstract Canis familiaris papillomavirus (CPV) is a member of the Papillomaviridae family and is found in dogs. After infection, the host can remain asymtomatic or develop benign ephitelial neoplasms such as papillomas and pigmented viral plaques, which can progress to cancer, in the form of squamous cell carcinoma (SCC). In humans, 227 types of human papillomavirus (HPV) have been described, with a well-established risk classification for cancer development. In addition, it is also known that variants of some high-risk HPV types may present different risks in respect of SCC development. In dogs, however, only a few types of CPV have been identified, despite the growing interest in this area, and knowledge on the genetic characterization of CPV variants is still scarce. Recent studies of CPV have shown that, as with HPV, benign neoplasia can develop into cancer, but it is believed that there are many more types and variants still to be described. Therefore, the aim of this study was to describe the genetics and biology of CPV, with the focus on what is known about lesions, geographic localization, virus types and variants.
DOI: 10.6084/m9.figshare.21087485.v1
title: New insights into Canis familiaris papillomaviruses genetics and biology: Is the genetic characterization of CPV types and their variants an important clinical issue?

description: Abstract Canis familiaris papillomavirus (CPV) is a member of the Papillomaviridae family and is found in dogs. After infection, the host can remain asymtomatic or develop benign ephitelial neoplasms such as papillomas and pigmented viral plaques, which can progress to cancer, in the form of squamous cell carcinoma (SCC). In humans, 227 types of human papillomavirus (HPV) have been described, with a well-established risk classification for cancer development. In addition, it is also known that variants of some high-risk HPV types may present different risks in respect of SCC development. In dogs, however, only a few types of CPV have been identified, despite the growing interest in this area, and knowledge on the genetic characterization of CPV variants is still scarce. Recent studies of CPV have shown that, as with HPV, benign neoplasia can develop into cancer, but it is believed that there are many more types and variants still to be described. Therefore, the aim of this study was to describe the genetics and biology of CPV, with the focus on what is known about lesions, geographic localization, virus types and variants.
DOI: 10.6084/m9.figshare.21070189
title: Semi-monthly Evaporation data during different periods Weishan Site.xlsx

description: This dataset is the semi-monthly evaporation data of four periods (from the second half of October to May, June, from July to September, and the first half of October) from 2006 to 2010 at Weishan Site.