cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.17632/v5rdmj2jb3.3
title: Raw Data

description: we report on that astragaloside IV attenuates hypoxia-induced cardiac hypertrophy via calpain-1-mediated mTOR activation. This is significant because our findings could be applied in the clinic for that astragaloside IV is effective against hypoxia-induced cardiac hypertrophy, apoptosis and autophagy, it is likely to be of great interest to the clinicians. Astragaloside IV (AsIV), one of the main active ingredients of Astragalus membranaceus, has been reported to have cardioprotective effects. However, the effect and mechanism of AsIV on hypoxia-induced myocardial hypertrophy are unclear. The aim of this study was to evaluate the effect of AsIV on hypoxia-induced cardiac injury by focusing on calpain-1 (CAPN1)-mediated mTOR activation. Hypoxia-induced cardiac hypertrophy was carried out in CAPN1 knockout and wild-type C57BL/6 mice in vivo and in H9C2 cells in vitro. The effects of AsIV, CAPN1 inhibition and 3-MA on hypertrophy, apoptosis, autophagy, [Ca2+]i, and the expression levels of CAPN1 and mTOR were assayed in cardiac tissue and H9C2 cells. The results showed that AsIV, as well as CAPN1 knockout, attenuated cardiac hypertrophy, apoptosis, and autophagy induced by hypoxia in mice, effects that were confirmed at the H9C2 cell level. In addition, AsIV treatment, CAPN1 inhibition and 3-MA increased p-mTOR expression and decreased [Ca2+]i, accompanied by decreased CAPN1 expression. Furthermore, H9C2 cells overexpressing CAPN1 with lentivirus infection aggravated hypoxia-induced myocardial hypertrophy, apoptosis, and p-mTOR inhibition. Notably, the effects of CAPN1 overexpression on cardiac injury and p-mTOR inhibition were reversed by AsIV treatment. In summary, our data indicated that AsIV could ameliorate hypoxia-induced cardiac hypertrophy by inhibiting apoptosis and autophagy via CAPN1-mediated mTOR activation.
DOI: 10.48670/moi-00141
title: EUROPEAN SEAS GRIDDED L4 SEA SURFACE HEIGHTS AND DERIVED VARIABLES REPROCESSED (1993-ONGOING)
DOI: 10.5281/zenodo.4415835
title: Simulated water models with Apoferritin for use in cryo-EM image simulations with amorphous ice

description: This dataset contains the atomic coordinates of several water models produced using the NAMD molecular dynamics software. The contents of each file is listed below. <strong><em>water_81_coords.pdb</em></strong> - water only in a cubic box with side length 81A <strong><em>water_243_coords.pdb</em></strong> - water only in a cubic box with side length 243A <strong><em>water_486_coords.pdb</em></strong> - water only in a cubic box with side length 486A <strong>water_567_coords.pdb</strong> - water only in a cubic box with side length 567A <strong><em>water_645_coords.pdb</em></strong> - water only in a cubic box with side length 645A <strong><em>water_735_coords.pdb</em></strong> - water only in a cubic box with side length 735A <strong><em>apo_water_723_coords.pdb</em></strong> - water and apoferritin in a cubic box with side length 723A where apoferritin atoms are constrained
DOI: 10.6084/m9.figshare.24637593
title: Supplementary file C from DNA methylation extends lifespan in the bumblebee <i>Bombus terrestris</i>

description: Annotation of differentially methylated genes that were hypomethylated in control workers 1 week post treatment.
DOI: 10.6084/m9.figshare.24637593.v1
title: Supplementary file C from DNA methylation extends lifespan in the bumblebee <i>Bombus terrestris</i>

description: Annotation of differentially methylated genes that were hypomethylated in control workers 1 week post treatment.
DOI: 10.6084/m9.figshare.24637596
title: Supplementary file A from DNA methylation extends lifespan in the bumblebee <i>Bombus terrestris</i>

description: Annotation of differentially methylated cytosines that were hypomethylated in control workers 1 week post treatment.
DOI: 10.6084/m9.figshare.24637596.v1
title: Supplementary file A from DNA methylation extends lifespan in the bumblebee <i>Bombus terrestris</i>

description: Annotation of differentially methylated cytosines that were hypomethylated in control workers 1 week post treatment.
DOI: 10.6084/m9.figshare.24637599
title: Supplementary file F from DNA methylation extends lifespan in the bumblebee <i>Bombus terrestris</i>

description: Annotation of differentially methylated cytosines that were hypermethylated in control workers 4 weeks post treatment.
DOI: 10.6084/m9.figshare.24637599.v1
title: Supplementary file F from DNA methylation extends lifespan in the bumblebee <i>Bombus terrestris</i>

description: Annotation of differentially methylated cytosines that were hypermethylated in control workers 4 weeks post treatment.
DOI: 10.6084/m9.figshare.24637602
title: Renard et al_SI.xlsx from DNA methylation extends lifespan in the bumblebee <i>Bombus terrestris</i>

description: Epigenetic alterations are a primary hallmark of ageing. In mammals, age-related epigenetic changes alter gene expression profiles, disrupt cellular homeostasis and physiological functions and, therefore, promote ageing. It remains unclear whether ageing is also driven by epigenetic mechanisms in invertebrates. Here, we used a pharmacological hypomethylating agent (RG108) to evaluate the effects of DNA methylation (DNAme) on lifespan in an insect—the bumble bee <i>Bombus terrestris</i>. RG108 extended mean lifespan by 43% and induced the differential methylation of genes involved in hallmarks of ageing, including DNA damage repair and chromatin organization. Furthermore, the longevity gene <i>sirt1</i> was overexpressed following the treatment. Functional experiments demonstrated that SIRT1 protein activity was positively associated with lifespan. Overall, our study indicates that epigenetic mechanisms are conserved regulators of lifespan in both vertebrates and invertebrates and provides new insights into how DNAme is involved in the ageing process in insects.
DOI: 10.6084/m9.figshare.24637602.v1
title: Renard et al_SI.xlsx from DNA methylation extends lifespan in the bumblebee <i>Bombus terrestris</i>

description: Epigenetic alterations are a primary hallmark of ageing. In mammals, age-related epigenetic changes alter gene expression profiles, disrupt cellular homeostasis and physiological functions and, therefore, promote ageing. It remains unclear whether ageing is also driven by epigenetic mechanisms in invertebrates. Here, we used a pharmacological hypomethylating agent (RG108) to evaluate the effects of DNA methylation (DNAme) on lifespan in an insect—the bumble bee <i>Bombus terrestris</i>. RG108 extended mean lifespan by 43% and induced the differential methylation of genes involved in hallmarks of ageing, including DNA damage repair and chromatin organization. Furthermore, the longevity gene <i>sirt1</i> was overexpressed following the treatment. Functional experiments demonstrated that SIRT1 protein activity was positively associated with lifespan. Overall, our study indicates that epigenetic mechanisms are conserved regulators of lifespan in both vertebrates and invertebrates and provides new insights into how DNAme is involved in the ageing process in insects.
DOI: 10.6084/m9.figshare.24637605
title: Supplementary file E from DNA methylation extends lifespan in the bumblebee <i>Bombus terrestris</i>

description: Annotation of differentially methylated cytosines that were hypomethylated in control workers 4 weeks post treatment.
DOI: 10.6084/m9.figshare.24637605.v1
title: Supplementary file E from DNA methylation extends lifespan in the bumblebee <i>Bombus terrestris</i>

description: Annotation of differentially methylated cytosines that were hypomethylated in control workers 4 weeks post treatment.
DOI: 10.6084/m9.figshare.24637608
title: Renard_et_al_FigS3.xls from DNA methylation extends lifespan in the bumblebee <i>Bombus terrestris</i>

description: Epigenetic alterations are a primary hallmark of ageing. In mammals, age-related epigenetic changes alter gene expression profiles, disrupt cellular homeostasis and physiological functions and, therefore, promote ageing. It remains unclear whether ageing is also driven by epigenetic mechanisms in invertebrates. Here, we used a pharmacological hypomethylating agent (RG108) to evaluate the effects of DNA methylation (DNAme) on lifespan in an insect—the bumble bee <i>Bombus terrestris</i>. RG108 extended mean lifespan by 43% and induced the differential methylation of genes involved in hallmarks of ageing, including DNA damage repair and chromatin organization. Furthermore, the longevity gene <i>sirt1</i> was overexpressed following the treatment. Functional experiments demonstrated that SIRT1 protein activity was positively associated with lifespan. Overall, our study indicates that epigenetic mechanisms are conserved regulators of lifespan in both vertebrates and invertebrates and provides new insights into how DNAme is involved in the ageing process in insects.
DOI: 10.6084/m9.figshare.24637608.v1
title: Renard_et_al_FigS3.xls from DNA methylation extends lifespan in the bumblebee <i>Bombus terrestris</i>

description: Epigenetic alterations are a primary hallmark of ageing. In mammals, age-related epigenetic changes alter gene expression profiles, disrupt cellular homeostasis and physiological functions and, therefore, promote ageing. It remains unclear whether ageing is also driven by epigenetic mechanisms in invertebrates. Here, we used a pharmacological hypomethylating agent (RG108) to evaluate the effects of DNA methylation (DNAme) on lifespan in an insect—the bumble bee <i>Bombus terrestris</i>. RG108 extended mean lifespan by 43% and induced the differential methylation of genes involved in hallmarks of ageing, including DNA damage repair and chromatin organization. Furthermore, the longevity gene <i>sirt1</i> was overexpressed following the treatment. Functional experiments demonstrated that SIRT1 protein activity was positively associated with lifespan. Overall, our study indicates that epigenetic mechanisms are conserved regulators of lifespan in both vertebrates and invertebrates and provides new insights into how DNAme is involved in the ageing process in insects.
DOI: 10.6084/m9.figshare.24637611
title: Supplementary file D from DNA methylation extends lifespan in the bumblebee <i>Bombus terrestris</i>

description: Annotation of differentially methylated genes that were hypermethylated in control workers 1 week post treatment.
DOI: 10.6084/m9.figshare.24637611.v1
title: Supplementary file D from DNA methylation extends lifespan in the bumblebee <i>Bombus terrestris</i>

description: Annotation of differentially methylated genes that were hypermethylated in control workers 1 week post treatment.
DOI: 10.6084/m9.figshare.24637614
title: Supplementary file B from DNA methylation extends lifespan in the bumblebee <i>Bombus terrestris</i>

description: Annotation of differentially methylated cytosines that were hypermethylated in control workers 1 week post treatment.
DOI: 10.6084/m9.figshare.24637614.v1
title: Supplementary file B from DNA methylation extends lifespan in the bumblebee <i>Bombus terrestris</i>

description: Annotation of differentially methylated cytosines that were hypermethylated in control workers 1 week post treatment.
DOI: 10.6084/m9.figshare.24637620
title: Supplementary file G from DNA methylation extends lifespan in the bumblebee <i>Bombus terrestris</i>

description: Annotation of differentially methylated genes that were hypomethylated in control workers 4 weeks post treatment.
DOI: 10.6084/m9.figshare.24637620.v1
title: Supplementary file G from DNA methylation extends lifespan in the bumblebee <i>Bombus terrestris</i>

description: Annotation of differentially methylated genes that were hypomethylated in control workers 4 weeks post treatment.
DOI: 10.5281/zenodo.8014315
title: Compiled datasets for enzymatic activities in Atlantic salmon tissues

description: Folder with two datasets of enzyme activities (CS and LDH) with associated details of fish, incuding genotypes, body size, and metabolic rates, and R codes for linear mixed models as described in the manuscript Prokkola et al (2023). See README file for more information.
DOI: 10.5281/zenodo.10208776
title: Compiled datasets and R codes for enzymatic activities in Atlantic salmon tissues

description: Folder with two datasets of enzyme activities (CS and LDH) with associated details of fish, incuding genotypes, body size, and metabolic rates, and R codes for linear mixed models as described in the manuscript Prokkola et al (submitted 2023). See README file for more information.
DOI: 10.5281/zenodo.8014314
title: Compiled datasets and R codes for enzymatic activities in Atlantic salmon tissues

description: Folder with two datasets of enzyme activities (CS and LDH) with associated details of fish, incuding genotypes, body size, and metabolic rates, and R codes for linear mixed models as described in the manuscript Prokkola et al (submitted 2023). See README file for more information.
DOI: 10.5281/zenodo.10209080
title: Prognosis and immunotherapeutic implications of molecular classification of cervical cancer based on immunophenoscore-related genes

description: Supplementary Table 1: Identification of DEGs in Cervical Cancer in TCGA Dataset. 
Supplementary Table 2: Acquisition of IPS-Related Genes Associated with Survival.
DOI: 10.5281/zenodo.10209081
title: Prognosis and immunotherapeutic implications of molecular classification of cervical cancer based on immunophenoscore-related genes

description: Supplementary Table 1: Identification of DEGs in Cervical Cancer in TCGA Dataset. 
Supplementary Table 2: Acquisition of IPS-Related Genes Associated with Survival.
DOI: 10.34740/kaggle/dsv/7063722
title: Egypt Gold Prices | Daily Updated
DOI: 10.5281/zenodo.10209176
title: Blendit data
DOI: 10.25403/upresearchdata.24558946.v1
title: Linear data representation of behavior counts, faecal glucocorticoid metabolites and selected organ weights of Sprague Dawley rats housed in semi-natural cage system and standard cages

description: For this study, a complex caging system (semi-natural cages) was designed furnished with different types of enrichment items together with increased cage space to determine if this could promote species-specific behaviour as a means of reducing stress and improving laboratory animal welfare. The study utilised previously described methods for welfare monitoring in animals namely: change in home cage behaviour, monitoring of faecal glucocorticoid metabolites and monitoring changes in body weights and selected organ weights.
DOI: 10.25403/upresearchdata.24558946
title: Linear data representation of behavior counts, faecal glucocorticoid metabolites and selected organ weights of Sprague Dawley rats housed in semi-natural cage system and standard cages

description: For this study, a complex caging system (semi-natural cages) was designed furnished with different types of enrichment items together with increased cage space to determine if this could promote species-specific behaviour as a means of reducing stress and improving laboratory animal welfare. The study utilised previously described methods for welfare monitoring in animals namely: change in home cage behaviour, monitoring of faecal glucocorticoid metabolites and monitoring changes in body weights and selected organ weights.
DOI: 10.6084/m9.figshare.24637670
title: Data set from Heat tolerance in <i>Drosophila melanogaster</i> is influenced by oxygen conditions and mutations in cell size control pathways

description: Raw data used in the analysis
DOI: 10.6084/m9.figshare.24637670.v1
title: Data set from Heat tolerance in <i>Drosophila melanogaster</i> is influenced by oxygen conditions and mutations in cell size control pathways

description: Raw data used in the analysis
DOI: 10.6084/m9.figshare.24637673
title: R code from Heat tolerance in <i>Drosophila melanogaster</i> is influenced by oxygen conditions and mutations in cell size control pathways

description: R code for statistical analysis
DOI: 10.6084/m9.figshare.24637673.v1
title: R code from Heat tolerance in <i>Drosophila melanogaster</i> is influenced by oxygen conditions and mutations in cell size control pathways

description: R code for statistical analysis
DOI: 10.6084/m9.figshare.24569851
title: De identified data set.csv

description: A team of expert clinicians and patient partners interested in self-management approaches designed a 48-question cross-sectional electronic survey; specifically targeted at individuals diagnosed with ILD. T. The survey was open for participation between September 2021 and December 2022, and responses were collected anonymously. Data were analysed descriptively for quantitative aspects and through thematic analysis for qualitative input<b>Results:</b><b> </b>104 patients accessed the survey and 89/104 (86%) reported a diagnosis of lung fibrosis, including 46/89 (52%) idiopathic pulmonary fibrosis (IPF) with 57/89 (64%) of participants diagnosed &gt;3 years and 59/89 (66%) female. 52/65(80%) were in the UK; 33/65 (51%) reported severe breathlessness medical research council MRC grade 3-4 and 32/65 (49%) disclosed co-morbid arthritis or joint problems. Of these, 18/83 (22%) used a hand- held spirometer, with only 6/17 (35%) advised on how to interpret the readings. Pulse oximetry devices were the most frequently used device by 35/71 (49%) and 20/64 (31%) measured their saturations more than once daily. 29/63 (46%) of respondents reported home-monitoring brought reassurance; of these, for 25/63 (40%) a feeling of control. 10/57 (18%) felt it had a negative effect, citing fluctuating readings as causing stress and ‘paranoia’. Nurse specialists were the most frequent source of help 24/63 (38%).
DOI: 10.57754/fdat.1d72q-rda67
title: Data for Multiple sluicing through an experimental lens: Amelioration effects, crosslinguistic variation, and processing

description: This dissertation investigates the acceptability status and amelioration factors affecting multiple sluicing in English, German, and Spanish in three experiment series. The two methods that have been used are acceptability judgment studies (AJS) on a 7-point scale, and a self-paced reading study (SPR).
Experiment Series 1 investigates the factors PREPOSITIONHOOD (swh2 is either prepositional or nominal) and WEIGHT (swh2 is either bare, explicit, (or heavy))
- Experiment 1: AJS in English. 2x3 design with PREPOSITIONHOOD and WEIGHT as factors
- Experiment 1': AJS in English. 2x2 design with PREPOSITIONHOOD and WEIGHT as factors
- Experiment 2: AJS in German. 2x2 design with PREPOSITIONHOOD and WEIGHT as factors
- Experiment 3: AJS in German. 2x2 design with PREPOSITIONHOOD and WEIGHT as factors
Experiment Series 2 investigates the factors CLAUSMATENESS (swh1 and swh2 originate within the same clause (i.e., clausemate) or across clause boundaries (i.e., non-clausemate) and ISLANDHOOD (the embedded clause is either an island or a non-island).
- Experiment 1: AJS in English. 2x2 design with CLAUSEMATENESS and ISLANDHOOD as factors
- Experiment 2: AJS in German. 2x2 design with CLAUSEMATENESS and ISLANDHOOD as factors
- Experiment 3: AJS in Spanish. 2x2 design with CLAUSEMATENESS and ISLANDHOOD as factors
- Experiment 4: SPR in German. 1x3 design with CLAUSEMATENESS (only clausemate) and ISLANDHOOD (non-island, adjunct island, and subject island)
Experiment Series 3 investigates the factors SOURCE (the elliptic clause is a short paraphrase of the antecedent or a full copy of the antecedent), SHIFTINESS (the subject in the embedded clause is either and shift or non-shifty), and EMBEDDING TYPE (the embedded clause in the antecedent is a relative clause (RC) or a complement of noun clause (NCC))

Experiment 1: AJS in German. 2x2 design with SOURCE and SHIFTINESS as factors
Experiment 2: AJS in German. 2x2 design with SOURCE and EMBEDDING TYPE as factors
Experiment 3: AJS in Spanish. 2x2 design with SOURCE and EMBEDDING TYPE as factors
 
description: SFB 833 - A7: Fokus und Extraktion in komplexen Konstruktionen und Inselkonfigurationen
description: SFB 833 - A7: Focus and Extraction in Complex Constructions and Islands
 
description: All the experiments in Experiment Series 3 were funded by Dr. James Griffiths, Junior Professor in English Linguistics, Englisches Seminar, University of Tübingen.
Prof. Dr. Holden Härtl, Chair of English Linguistics, English Linguistics, University of Kassel, funded Experiment 4 in Experiment Series 2.
DOI: 10.6084/m9.figshare.24637551
title: Thesium chinense raw data

description: <b>Cytotoxic activity of </b><b>phenolic compounds</b><b> in Bairui Granules obtained from the Chinese medicinal plant </b><b><i>Thesium chinense</i></b>
DOI: 10.6084/m9.figshare.24637551.v1
title: Thesium chinense raw data

description: <b>Cytotoxic activity of </b><b>phenolic compounds</b><b> in Bairui Granules obtained from the Chinese medicinal plant </b><b><i>Thesium chinense</i></b>
DOI: 10.6084/m9.figshare.24637685
title: code from Beluga whale and bottlenose dolphin ACE2 proteins allow cell entry mediated by spike protein from three variants of SARS-CoV-2

description: Annotated code for graphing and statistical analysis.
DOI: 10.6084/m9.figshare.24637685.v1
title: code from Beluga whale and bottlenose dolphin ACE2 proteins allow cell entry mediated by spike protein from three variants of SARS-CoV-2

description: Annotated code for graphing and statistical analysis.
DOI: 10.6084/m9.figshare.24637691
title: luciferase assay data from Beluga whale and bottlenose dolphin ACE2 proteins allow cell entry mediated by spike protein from three variants of SARS-CoV-2

description: Compilation of luciferase assay readouts (indicative of viral cell entry) for all ace2 types, variants, dilution levels, and experiments.
DOI: 10.6084/m9.figshare.24637691.v1
title: luciferase assay data from Beluga whale and bottlenose dolphin ACE2 proteins allow cell entry mediated by spike protein from three variants of SARS-CoV-2

description: Compilation of luciferase assay readouts (indicative of viral cell entry) for all ace2 types, variants, dilution levels, and experiments.
DOI: 10.25345/c5mc8rs7q
title: MassIVE MSV000093502 - 32 Standards mixture_treated with aqc
title: Data dependent analysis of a mixture of standard molecules treated with aqc
DOI: 10.25592/uhhfdm.13109
title: XRF analysis on metal castings from Lübeck, Germany

description: XRF analysis was performed in August 2022 on 7 metal artefacts at different places in Lübeck, Germany: Epitaph of Bartholomäus Heisegger (St. Anne's Museum) Plaque of Ludeke Lammeshoved (St. Anne's Museum) Font (St. Aegidien Kirche) Font (Cathedral) Gravestone Serkem (Cathedral) Gravestone Huttenrock (St. Mary's Church) Sacrament House (St. Mary's Church) The results were presented at the conference "LÜBECK ALS ZENTRUM DES SPÄTMITTELALTERLICHEN METALLGUSSES" The documentation of the measured spots is summarized in <strong>01_Measuring spots.pdf</strong>. All data uploaded here was recorded with the mobile XRF spectrometer ELIO (XGLab S.R.L., Italy, software version 1.5.7.7). Raw spectra are saved within project (.xga) files (see folder <strong>02_xga.zip</strong>) and exported as spectrum (.spx) and text (.txt) files (see folder <strong>03_spx.zip</strong> and folder <strong>04_txt.zip</strong>). The.spx files were evaluated with Esprit Reveal software (Bruker Nano GmbH, Germany, version 2.2.1.4280) and results were exported as .xlsx files (see folder <strong>05_xlsx.zip</strong>). All raw and evaluated spectra, as well as the results were copied in a summary file (see file <strong>06_Summary of XRF results.pdf</strong>).
description: The research for this project was funded by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) under Germany´s Excellence Strategy – EXC 2176 'Understanding Written Artefacts: Material, Interaction and Transmission in Manuscript Cultures', project no. 390893796. The research was conducted within the scope of the Centre for the Study of Manuscript Cultures (CSMC) at Universität Hamburg.