cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.6194696
title: Effects and biotransformation of the mycotoxin deoxynivalenol in growing pigs fed with naturally contaminated pelleted grains with and without the addition of <i>Coriobacteriaceum</i> DSM 11798

description: Deoxynivalenol (DON) is one of the most prevalent <i>Fusarium</i> mycotoxins in grain and can cause economic losses in pig farming due to reduced feed consumption and lower weight gains. Biodetoxification of mycotoxins using bacterial strains has been a focus of research for many years. However, only a few <i>in vivo</i> studies have been conducted on the effectiveness of microbial detoxification of fusariotoxins. This study was therefore aimed at investigating the effect of a feed additive containing the bacterial strain <i>Coriobacteriaceum</i> DSM 11798 (the active ingredient in <i>Biomin</i>® BBSH 797) on growth performance and blood parameters, as well as uptake and metabolism of DON, in growing pigs. Forty-eight crossbred (Landrace-Yorkshire/Duroc-Duroc) weaning pigs were fed with pelleted feed made from naturally contaminated oats, with DON at four concentration levels: (1) control diet (DON −1), (2) low-contaminated diet (DON = 0.92 mg kg<sup>−1</sup>), (3) medium-contaminated diet (DON = 2.2 mg kg<sup>−1</sup>) and (4) high-contaminated diet (DON = 5.0 mg kg<sup>−1</sup>) and equivalent diets containing DSM 11798 as feed additive. During the first 7 days of exposure, pigs in the highest-dose group showed a 20–28% reduction in feed intake and a 24–34% reduction in weight gain compared with pigs in the control and low-dose groups. These differences were levelled out by study completion. Towards the end of the experiment, dose-dependent reductions in serum albumin, globulin and total serum protein were noted in the groups fed with DON-contaminated feed compared with the controls. The addition of DSM 11798 had no effect on the DON-related clinical effects or on the plasma concentrations of DON. The ineffectiveness of the feed additive in the present study could be a consequence of its use in pelleted feed, which might have hindered its rapid release, accessibility or detoxification efficiency in the pig’s gastrointestinal tract.
DOI: 10.6084/m9.figshare.6194696.v2
title: Effects and biotransformation of the mycotoxin deoxynivalenol in growing pigs fed with naturally contaminated pelleted grains with and without the addition of <i>Coriobacteriaceum</i> DSM 11798

description: Deoxynivalenol (DON) is one of the most prevalent <i>Fusarium</i> mycotoxins in grain and can cause economic losses in pig farming due to reduced feed consumption and lower weight gains. Biodetoxification of mycotoxins using bacterial strains has been a focus of research for many years. However, only a few <i>in vivo</i> studies have been conducted on the effectiveness of microbial detoxification of fusariotoxins. This study was therefore aimed at investigating the effect of a feed additive containing the bacterial strain <i>Coriobacteriaceum</i> DSM 11798 (the active ingredient in <i>Biomin</i>® BBSH 797) on growth performance and blood parameters, as well as uptake and metabolism of DON, in growing pigs. Forty-eight crossbred (Landrace-Yorkshire/Duroc-Duroc) weaning pigs were fed with pelleted feed made from naturally contaminated oats, with DON at four concentration levels: (1) control diet (DON −1), (2) low-contaminated diet (DON = 0.92 mg kg<sup>−1</sup>), (3) medium-contaminated diet (DON = 2.2 mg kg<sup>−1</sup>) and (4) high-contaminated diet (DON = 5.0 mg kg<sup>−1</sup>) and equivalent diets containing DSM 11798 as feed additive. During the first 7 days of exposure, pigs in the highest-dose group showed a 20–28% reduction in feed intake and a 24–34% reduction in weight gain compared with pigs in the control and low-dose groups. These differences were levelled out by study completion. Towards the end of the experiment, dose-dependent reductions in serum albumin, globulin and total serum protein were noted in the groups fed with DON-contaminated feed compared with the controls. The addition of DSM 11798 had no effect on the DON-related clinical effects or on the plasma concentrations of DON. The ineffectiveness of the feed additive in the present study could be a consequence of its use in pelleted feed, which might have hindered its rapid release, accessibility or detoxification efficiency in the pig’s gastrointestinal tract.
DOI: 10.6084/m9.figshare.6194615
title: peripheral lymphocyte subpopulations of SLE

description: The data include baseline character of SLE patients with different infection stauts as well as peripheral lymphocyte subpopulations of the patients and health controls.
DOI: 10.6084/m9.figshare.6194615.v1
title: peripheral lymphocyte subpopulations of SLE

description: The data include baseline character of SLE patients with different infection stauts as well as peripheral lymphocyte subpopulations of the patients and health controls.
DOI: 10.6084/m9.figshare.6194492
title: Antar_data_Paper_copia_csv.csv

description: O município de Aquiraz localizado na Grande Fortaleza, ainda possui extensas áreas naturais de vegetação em diferentes estágios de conservação. Essas áreas podem ser enquadradas como formações do Complexo Vegetacional da Zona Litorânea, as quais incluem elementos de Restinga, Cerrado e Caatinga. Apesar dessa significativa quantidade de áreas naturais, a razão do número de coletas botânicas por área ainda é baixa no município, ainda mais se comparado a Fortaleza, município vizinho. Assim, o objetivo deste trabalho é contribuir com o conhecimento acerca da vegetação do Complexo Vegetacional da Zona Litorânea do município de Aquiraz.
DOI: 10.6084/m9.figshare.6194492.v1
title: Antar_data_Paper_copia_csv.csv

description: O município de Aquiraz localizado na Grande Fortaleza, ainda possui extensas áreas naturais de vegetação em diferentes estágios de conservação. Essas áreas podem ser enquadradas como formações do Complexo Vegetacional da Zona Litorânea, as quais incluem elementos de Restinga, Cerrado e Caatinga. Apesar dessa significativa quantidade de áreas naturais, a razão do número de coletas botânicas por área ainda é baixa no município, ainda mais se comparado a Fortaleza, município vizinho. Assim, o objetivo deste trabalho é contribuir com o conhecimento acerca da vegetação do Complexo Vegetacional da Zona Litorânea do município de Aquiraz.
DOI: 10.17633/rd.brunel.6194483
title: On Gc, Jc and the characterisation of the mode-I fracture resistance in delamination or adhesive debonding dataset

description: This fileset contains data from the article: L. Škec, G. Alfano and G. Jelenić "On Gc, Jc and the characterisation of the mode-I fracture resistance in delamination or adhesive debonding", International Journal of Solids and Structures. In press, 2018.<br>
DOI: 10.6084/m9.figshare.6194429
title: Modeling brain dynamics in brain tumor patients using TVB: Supplementary data

description: Supplementary material for paper "Modeling brain dynamics in brain tumor patients using The Virtual Brain" by Hannelore Aerts, Michael Schirner, Ben Jeurissen, Dirk Van Roost, Eric Achten, Petra Ritter and Daniele Marinazzo.<br><br>Figures show limited impact of TR on construction of FC matrices and parameter space exploration. In particular, figures show the similarity between simulated FC matrices using different TR values ("FCsim_avgFisherZ_TR.png"), and mean FC strength for both simulated FC matrices per subject ("FCsim_TR"). Further, parameter space exploration was performed using both different TR values, showing similar parameter profiles across TR, per subject ("PSE_TR_CON06T1.png" for control subject, and "PSE_TR_PAT16T1.png" for glioma patient).<br>
DOI: 10.6084/m9.figshare.6194327
title: Advanced lattice Boltzmann scheme for high-Reynolds-number magneto-hydrodynamic flows

description: Is the lattice Boltzmann method suitable to investigate numerically high-Reynolds-number magneto-hydrodynamic (MHD) flows? It is shown that a standard approach based on the Bhatnagar–Gross–Krook (BGK) collision operator rapidly yields unstable simulations as the Reynolds number increases. In order to circumvent this limitation, it is here suggested to address the collision procedure in the space of central moments for the fluid dynamics. Therefore, an hybrid lattice Boltzmann scheme is introduced, which couples a central-moment scheme for the velocity with a BGK scheme for the space-and-time evolution of the magnetic field. This method outperforms the standard approach in terms of stability, allowing us to simulate high-Reynolds-number MHD flows with non-unitary Prandtl number while maintaining accuracy and physical consistency.
DOI: 10.6084/m9.figshare.6194327.v1
title: Advanced lattice Boltzmann scheme for high-Reynolds-number magneto-hydrodynamic flows

description: Is the lattice Boltzmann method suitable to investigate numerically high-Reynolds-number magneto-hydrodynamic (MHD) flows? It is shown that a standard approach based on the Bhatnagar–Gross–Krook (BGK) collision operator rapidly yields unstable simulations as the Reynolds number increases. In order to circumvent this limitation, it is here suggested to address the collision procedure in the space of central moments for the fluid dynamics. Therefore, an hybrid lattice Boltzmann scheme is introduced, which couples a central-moment scheme for the velocity with a BGK scheme for the space-and-time evolution of the magnetic field. This method outperforms the standard approach in terms of stability, allowing us to simulate high-Reynolds-number MHD flows with non-unitary Prandtl number while maintaining accuracy and physical consistency.
DOI: 10.6084/m9.figshare.6194315
title: Response of soil C- and O-horizon and terrestrial moss samples to various lithological units and mineralization in southern Norway

description: All data are also downloadable as an Excel file.
DOI: 10.6084/m9.figshare.6194315.v1
title: Response of soil C- and O-horizon and terrestrial moss samples to various lithological units and mineralization in southern Norway

description: All data are also downloadable as an Excel file.
DOI: 10.6084/m9.figshare.6194312
title: Response of soil C- and O-horizon and terrestrial moss samples to various lithological units and mineralization in southern Norway

description: A Google Earth file showing the analytical results of moss, O- and C horizon at all sample sites in addition to topographical details is available.
DOI: 10.6084/m9.figshare.6194312.v1
title: Response of soil C- and O-horizon and terrestrial moss samples to various lithological units and mineralization in southern Norway

description: A Google Earth file showing the analytical results of moss, O- and C horizon at all sample sites in addition to topographical details is available.
DOI: 10.6084/m9.figshare.6194306
title: Response of soil C- and O-horizon and terrestrial moss samples to various lithological units and mineralization in southern Norway

description: A Google Earth file showing the analytical results of moss, O- and C horizon at all sample sites in addition to topographical details is available.
DOI: 10.6084/m9.figshare.6194306.v1
title: Response of soil C- and O-horizon and terrestrial moss samples to various lithological units and mineralization in southern Norway

description: A Google Earth file showing the analytical results of moss, O- and C horizon at all sample sites in addition to topographical details is available.
DOI: 10.6084/m9.figshare.6194288
title: Onchocerciasis Transmission Interruption in Bioko Island, Equatorial Guinea

description: We performed a cross-sectional study to demonstrate that updated WHO criteria for stopping mass drug administration (MDA) against onchocerciasis have been met in Bioko Island (Equatorial Guinea). This study was carried out from September, 2016 to January, 2017. A total of 7,052 aged 5- to 9-year-old school children, were included. Onchocerciasis/lymphatic Filariasis rapid diagnostic tests (RDTs) and ELISA/PCR were performed. <br>
DOI: 10.6084/m9.figshare.6194261
title: Supplementary Material for: Genome-Wide Association Study and Transcriptome Analysis Provide New Insights into the White/Red Earlobe Color Formation in Chicken

description: <b><i>Background/Aims:</i></b> Earlobe color is a typical external trait in chicken. There are some previous studies showing that the chicken white/red earlobe color is a polygenic and sex-linked trait in some breeds, but its molecular genetic and histological mechanisms still remain unclear. <b><i>Methods:</i></b> We herein utilized histological section, genome-wide association study (GWAS) and RNA-seq, further to investigate the potential histological and molecular genetic mechanisms of white/red earlobe formation in Qiangyuan Partridge chicken (QYP). <b><i>Results:</i></b> through histological section analysis, we found the dermal papillary layer of red earlobes had many more blood vessels than that of white earlobes. And we identified a total of 44 SNPs from Chromosome 1, 2, 3, 4, 9, 10, 11, 13, 19, 20, 23 and Z, that was significantly associated with the chicken white/red earlobe color from GWAS, along with 73 significantly associated genes obtained (e.g., <i>PIK3CB, B4GALT1</i> and <i>TP63</i>), supporting the fact that the white/red earlobe color was also polygenic and sex-linked in QYP. Importantly, <i>PIK3CB</i> and <i>B4GALT1</i> are both involved in the biological process of angiogenesis, which may directly give rise to the chicken white earlobe formation through regulating blood vessel density in chicken earlobe. Additionally, through contrast of RNA-seq profiles between white earlobe skins and red earlobe skins, we further identified <i>TP63</i> and <i>CDH1</i> differentially expressed. Combined with the existing knowledge of TP63 in epithelial development and tumor angiogenesis, we propose that down-regulated <i>TP63</i> in white earlobes may play roles in thickening the skin and decreasing the vessel numbers in dermal papillary layer, thereby contributing to the white earlobe formation via paling the redness of the skin in QYP, but the specific mechanism remains to be further clarified. <b><i>Conclusion:</i></b> our findings advance the existing understanding of the white earlobe formation, as well as provide new clues to understand the molecular mechanism of chicken white/red earlobe color formation.
DOI: 10.6084/m9.figshare.6194252
title: Supplementary Material for: High Glucose-Induced Reactive Oxygen Species Stimulates Human Mesenchymal Stem Cell Migration Through Snail and EZH2-Dependent E-Cadherin Repression

description: <b><i>Background/Aims:</i></b> Glucose plays an important role in stem cell fate determination and behaviors. However, it is still not known how glucose contributes to the precise molecular mechanisms responsible for stem cell migration. Thus, we investigate the effect of glucose on the regulation of the human umbilical cord blood-derived mesenchymal stem cell (hUCB-MSC) migration, and analyze the mechanism accompanied by this effect. <b><i>Methods:</i></b> Western blot analysis, wound healing migration assays, immunoprecipitation, and chromatin immunoprecipitation assay were performed to investigate the effect of high glucose on hUCB-MSC migration. Additionally, hUCB-MSC transplantation was performed in the mouse excisional wound splinting model. <b><i>Results:</i></b> High concentration glucose (25 mM) elicits hUCB-MSC migration compared to normal glucose and high glucose-pretreated hUCB-MSC transplantation into the wound sites in mice also accelerates skin wound repair. We therefore elucidated the detailed mechanisms how high glucose induces hUCB-MSC migration. We showed that high glucose regulates E-cadherin repression through increased Snail and EZH2 expressions. And, we found high glucose-induced reactive oxygen species (ROS) promotes two signaling; JNK which regulates γ–secretase leading to the cleavage of Notch proteins and PI3K/Akt signaling which enhances GSK-3β phosphorylation. High glucose-mediated JNK/Notch pathway regulates the expression of EZH2, and PI3K/Akt/GSK-3β pathway stimulates Snail stabilization, respectively. High glucose enhances the formation of EZH2/Snail/HDAC1 complex in the nucleus, which in turn causes E-cadherin repression. <b><i>Conclusion:</i></b> This study reveals that high glucose-induced ROS stimulates the migration of hUCB-MSC through E-cadherin repression via Snail and EZH2 signaling pathways.
DOI: 10.6084/m9.figshare.6194180
title: Supplementary Material for: Lipid-Lowering Pretreatment and Outcome Following Intravenous Thrombolysis for Acute Ischaemic Stroke: A Post Hoc Analysis of the Enhanced Control of Hypertension and Thrombolysis Stroke Study Trial

description: <b><i>Background:</i></b> Debate exists as to whether statin pretreatment confers an increased risk of 90-day mortality and symptomatic intracranial haemorrhage (sICH) in acute ischaemic stroke (AIS) patients treated with intravenous thrombolysis. We assessed the effects of undifferentiated lipid-lowering pretreatment on outcomes and interaction with low-dose versus standard-dose alteplase in a post hoc subgroup ­analysis of the Enhanced Control of Hypertension and Thrombolysis Stroke Study. <b><i>Methods:</i></b> In all, 3,284 thrombolysis-eligible AIS patients (mean age 66.6 years; 38% women), with information on lipid-lowering pretreatment, were randomly assigned to low-dose (0.6 mg/kg) or standard-dose (0.9 mg/kg) intravenous alteplase within 4.5 h of symptom onset. Of the total number of patients, 615 (19%) received statin or other lipid-lowering pretreatment. The primary clinical outcome was combined endpoint of death or disability (modified Rankin Scale scores 2–6) at 90 days. <b><i>Results:</i></b> Compared with patients with no lipid-lowering pretreatment, those with lipid-lowering pretreatment were significantly older, more likely to be non-Asian and more likely to have a medical history including vascular co-morbidity. After propensity analysis assessment and adjustment for important baseline variables at the time of randomisation, as well as imbalances in management during the first 7 days of hospital admission, there were no significant differences in mortality (OR 0.85; 95% CI 0.58–1.25, <i>p</i> = 0.42), or in overall ­90-day death and disability (OR 0.85, 95% CI 0.67–1.09, <i>p</i> = 0.19), despite a significant decrease in sICH among those with ­lipid-lowering pretreatment according to the European Co-operative Acute Stroke Study 2 definition (OR 0.49, 95% CI 0.28–0.83, <i>p</i> = 0.009). No differences in key efficacy or safety outcomes were seen in patients with and without lipid-lowering pretreatment between low- and standard-dose alteplase arms. <b><i>Conclusions:</i></b> Lipid-lowering pretreatment is not associated with adverse outcome in AIS patients treated with intravenous alteplase, whether assessed by 90-day death and disability or death alone.
DOI: 10.6084/m9.figshare.6194180.v1
title: Supplementary Material for: Lipid-Lowering Pretreatment and Outcome Following Intravenous Thrombolysis for Acute Ischaemic Stroke: A Post Hoc Analysis of the Enhanced Control of Hypertension and Thrombolysis Stroke Study Trial

description: <b><i>Background:</i></b> Debate exists as to whether statin pretreatment confers an increased risk of 90-day mortality and symptomatic intracranial haemorrhage (sICH) in acute ischaemic stroke (AIS) patients treated with intravenous thrombolysis. We assessed the effects of undifferentiated lipid-lowering pretreatment on outcomes and interaction with low-dose versus standard-dose alteplase in a post hoc subgroup ­analysis of the Enhanced Control of Hypertension and Thrombolysis Stroke Study. <b><i>Methods:</i></b> In all, 3,284 thrombolysis-eligible AIS patients (mean age 66.6 years; 38% women), with information on lipid-lowering pretreatment, were randomly assigned to low-dose (0.6 mg/kg) or standard-dose (0.9 mg/kg) intravenous alteplase within 4.5 h of symptom onset. Of the total number of patients, 615 (19%) received statin or other lipid-lowering pretreatment. The primary clinical outcome was combined endpoint of death or disability (modified Rankin Scale scores 2–6) at 90 days. <b><i>Results:</i></b> Compared with patients with no lipid-lowering pretreatment, those with lipid-lowering pretreatment were significantly older, more likely to be non-Asian and more likely to have a medical history including vascular co-morbidity. After propensity analysis assessment and adjustment for important baseline variables at the time of randomisation, as well as imbalances in management during the first 7 days of hospital admission, there were no significant differences in mortality (OR 0.85; 95% CI 0.58–1.25, <i>p</i> = 0.42), or in overall ­90-day death and disability (OR 0.85, 95% CI 0.67–1.09, <i>p</i> = 0.19), despite a significant decrease in sICH among those with ­lipid-lowering pretreatment according to the European Co-operative Acute Stroke Study 2 definition (OR 0.49, 95% CI 0.28–0.83, <i>p</i> = 0.009). No differences in key efficacy or safety outcomes were seen in patients with and without lipid-lowering pretreatment between low- and standard-dose alteplase arms. <b><i>Conclusions:</i></b> Lipid-lowering pretreatment is not associated with adverse outcome in AIS patients treated with intravenous alteplase, whether assessed by 90-day death and disability or death alone.
DOI: 10.6084/m9.figshare.6194171
title: Dataset: Too Trivial To Test?

description: Data set accompanying the paper <i>Too Trivial To Test? An Inverse View on Defect Prediction To Identify Methods With Low Fault Risk</i><br>
DOI: 10.6084/m9.figshare.6194165.v1
title: Collaborative Vehicle Routing Problem with Rough Location using Extended Ant Colony Optimization Algorithm

description: In this paper, we propose a collaborative vehicle routing problem with rough location (CVRPRL), which considers both the security of sharing detailed customer information and the efficiency of resource investment and configuration. <br>
DOI: 10.6084/m9.figshare.6194165.v2
title: Collaborative Vehicle Routing Problem with Rough Location using Extended Ant Colony Optimization Algorithm

description: This is data of the manusrcipt "Collaborative Vehicle Routing Problem with Rough Location using Extended Ant Colony Optimization Algorithm". All data are the file in txt format, which are consistent with the real-world case via computer simulation. For example, DATA_N_60_D_4_V_12 represents the data contain 4 depots, 60 customers and 12 vehicle. The DATA_N_77_D_3_V_9.txt and DATA_N_97_D_3_V_9.txt is used in Section 5.2 for figure 4 and figure 5, respectively. Other data is used in Section 5.3. <br>
DOI: 10.6084/m9.figshare.6194165.v3
title: Collaborative Vehicle Routing Problem with Rough Location using Extended Ant Colony Optimization Algorithm

description: This is the experimental data of the manuscript entitled "Collaborative Vehicle Routing Problem with Rough Location using Extended Ant Colony Optimization Algorithm". All data are generated through computer simulation and saved in the file with txt format. The data are consistent with the real-world case. For example, DATA_N_60_D_4_V_12 represents the case that contains 4 depots, 60 customers and 12 vehicles. The “DATA_N_77_D_3_V_9.txt” and “DATA_N_97_D_3_V_9.txt” are used in Section 5.2 as illustrative examples corresponding to figure 4 and figure 5, respectively. Other data are used in Section 5.3.
DOI: 10.6084/m9.figshare.6194165.v4
title: Collaborative Vehicle Routing Problem with Rough Location using Extended Ant Colony Optimization Algorithm

description: This is the experimental data of the manuscript entitled "Collaborative Vehicle Routing Problem with Rough Location using Extended Ant Colony Optimization Algorithm". All data are generated through computer simulation and saved in the file with txt format. The data are consistent with the real-world case. For example, DATA_N_60_D_4_V_12 represents the case that contains 4 depots, 60 customers and 12 vehicles. The “DATA_N_77_D_3_V_9.txt” and “DATA_N_97_D_3_V_9.txt” are used in Section 5.2 as illustrative examples corresponding to figure 4 and figure 5, respectively. Other data are used in Section 5.3.