cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.15468/dl.a4zw4u
title: Occurrence Download

description: A dataset containing 252 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is China",
 "TaxonKey is Sesbania cannabina (Retz.) Poir."
 ]
}

 The dataset includes 252 records from 21 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0068597-241126133413365/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.1285/i9788883052156v1p165
title: Colophon
DOI: 10.34816/efa.archives.1180722
title: Philippes-PHILIPPES-1-1922-Fouilles de Philippes 1922 (1922).

description: Référence : PHILIPPES-1-1922<br />
DOI: 10.34816/efa.archives.1180730
title: Philippes-PHILIPPES-1-1924-Fouilles de Philippes 1924 (1924).

description: Référence : PHILIPPES-1-1924<br />
DOI: 10.34816/efa.archives.1180724
title: Philippes-PHILIPPES-1-1922-02-Fouilles et sondages dans le secteur compris entre le rocher porteur des inscriptions rupestres et le temple de Silvain, et recherches menées à Dérékler, au théâtre, au temple de Silvain et dans le secteur occidental de la ville romaine (1922).

description: Référence : PHILIPPES-1-1922-02<br />Domaine : Architecture; Fouille<br />
DOI: 10.34816/efa.archives.1180725
title: Philippes-PHILIPPES-1-1922-03-Grand sanctuaire rupestre de Philippes (1922).

description: Référence : PHILIPPES-1-1922-03<br />Domaine : Architecture; Fouille<br />
DOI: 10.34816/efa.archives.1180733
title: Philippes-PHILIPPES-1-1925-Fouilles de Philippes 1925 (1925).

description: Référence : PHILIPPES-1-1925<br />Domaine : Architecture<br />
DOI: 10.34816/efa.archives.1180736
title: Philippes-PHILIPPES-1-1927-02-Fouille du théâtre (1927).

description: Référence : PHILIPPES-1-1927-02<br />Domaine : Architecture; Fouille<br />
DOI: 10.34816/efa.archives.1180735
title: Philippes-PHILIPPES-1-1927-01-Théâtre de Philippes (1927).

description: Référence : PHILIPPES-1-1927-01<br />Domaine : Architecture; Fouille<br />
DOI: 10.34816/efa.archives.1180734
title: Philippes-PHILIPPES-1-1927-Fouilles de Philippes 1927 (1927).

description: Référence : PHILIPPES-1-1927<br />
DOI: 10.34816/efa.archives.1180731
title: Philippes-PHILIPPES-1-1924-01-Fouilles du théâtre, de la région des portiques, de la basilique de Dérékler (1924).

description: Référence : PHILIPPES-1-1924-01<br />Domaine : Architecture; Fouille<br />
DOI: 10.34816/efa.archives.1180729
title: Philippes-PHILIPPES-1-1923-03-Travaux de G. Hinnisdaels (1923).

description: Référence : PHILIPPES-1-1923-03<br />Domaine : Architecture; Fouille<br />
DOI: 10.34816/efa.archives.1180742
title: Philippes-PHILIPPES-1-1930-02-Fouilles et expropriations (1930).

description: Référence : PHILIPPES-1-1930-02<br />Domaine : Architecture; Fouille<br />
DOI: 10.34816/efa.archives.1180737
title: Philippes-PHILIPPES-1-1928-Fouilles de Philippes 1928 (1928).

description: Référence : PHILIPPES-1-1928<br />
DOI: 10.34816/efa.archives.1180739
title: Philippes-PHILIPPES-1-1928-02-Campagne effectuée du 28 mai au 9 juin 1928 au théâtre (1928).

description: Référence : PHILIPPES-1-1928-02<br />Domaine : Architecture; Fouille<br />
DOI: 10.34816/efa.archives.1180743
title: Philippes-PHILIPPES-1-1931-Fouilles de Philippes 1931 (1931).

description: Référence : PHILIPPES-1-1931<br />
DOI: 10.34816/efa.archives.1180741
title: Philippes-PHILIPPES-1-1930-01-Fouilles de l'agora, du temple corinthien, du forum (1930).

description: Référence : PHILIPPES-1-1930-01<br />Domaine : Architecture; Fouille<br />
DOI: 10.34816/efa.archives.1180740
title: Philippes-PHILIPPES-1-1930-Fouilles de Philippes 1930 (1930).

description: Référence : PHILIPPES-1-1930<br />
DOI: 10.34816/efa.archives.1180727
title: Philippes-PHILIPPES-1-1923-01-Fouilles du théâtre, du secteur des portiques, de la basilique de Dérékler, et relations avec les autorités et la population locale (1923).

description: Référence : PHILIPPES-1-1923-01<br />Domaine : Architecture; Fouille<br />
DOI: 10.34816/efa.archives.1180738
title: Philippes-PHILIPPES-1-1928-01-Fouille du théâtre de Philippes (1928).

description: Référence : PHILIPPES-1-1928-01<br />Domaine : Architecture; Fouille<br />
DOI: 10.34816/efa.archives.1180728
title: Philippes-PHILIPPES-1-1923-02-Fouilles du théâtre, de Dérékler et des portiques (1923).

description: Référence : PHILIPPES-1-1923-02<br />Domaine : Architecture; Fouille<br />
DOI: 10.34816/efa.archives.1180726
title: Philippes-PHILIPPES-1-1923-Fouilles de Philippes 1923 (1923).

description: Référence : PHILIPPES-1-1923<br />
DOI: 10.34816/efa.archives.1180711
title: Philippes-PHILIPPES-1-1920-01-Instructions aux fouilleurs, pour les fouilles de Philippes, Dikili-Tash et Thasos (1920).

description: Référence : PHILIPPES-1-1920-01<br />Domaine : Architecture; Fouille<br />
DOI: 10.15468/dl.8usmm9
title: Occurrence Download

description: A dataset containing 277 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Pterycombus brama Fries, 1837",
 "HasGeospatialIssue is false",
 "HasCoordinate is true",
 "OccurrenceStatus is Present",
 "Year is greater than or equal to 1900"
 ]
}

 The dataset includes 277 records from 29 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0068599-241126133413365/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.34816/efa.archives.1180699
title: Philippes-PHILIPPES-1-1890-01-Philippes, Drama et Juredjik : récit de voyage par Falconnet (1890).

description: Référence : PHILIPPES-1-1890-01<br />
DOI: 10.15468/dl.zmjumg
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Ectoedemia weaveri (Stainton, 1855) Scoble, 1983",
 "Year is 2016",
 "Country is Netherlands"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0068600-241126133413365/datasets/export for details.
DOI: 10.34816/efa.archives.1180703
title: Philippes-PHILIPPES-1-1911-1914-02-Croquis du sanctuaire à l'autel, photographies des sanctuaires rupestres : reliefs et inscriptions.

description: Référence : PHILIPPES-1-1911-1914-02<br />Domaine : Décor architectural; Architecture; Épigraphie<br />
DOI: 10.34816/efa.archives.1180702
title: Philippes-PHILIPPES-1-1911-1914-01-Croquis, dont porte de Neapolis, théâtre, reliefs rupestres.

description: Référence : PHILIPPES-1-1911-1914-01<br />Domaine : Décor architectural; Architecture<br />
DOI: 10.34816/efa.archives.1180701
title: Philippes-PHILIPPES-1-1911-1914-Fouilles de Philippes 1911-1914 (1911-1914) : croquis et photographies commentées par Ch. Avezou.

description: Référence : PHILIPPES-1-1911-1914<br />Domaine : Architecture<br />
DOI: 10.34816/efa.archives.1180700
title: Philippes-PHILIPPES-1-1890-02-De Rovala à Philippes : récit de voyage par M. Tabouret (1890).

description: Référence : PHILIPPES-1-1890-02<br />
DOI: 10.34816/efa.archives.1180697
title: Philippes-PHILIPPES-1-12-Fouilles de Philippes 1922 (1922).

description: Référence : PHILIPPES-1-12<br />Domaine : Décor architectural; Architecture<br />
DOI: 10.34816/efa.archives.1180696
title: Philippes-PHILIPPES-1-11-Fouilles de Philippes 1945 (1945).

description: Référence : PHILIPPES-1-11<br />Domaine : Architecture<br />
DOI: 10.34816/efa.archives.1180705
title: Philippes-PHILIPPES-1-1911-1914-04-Croquis et photographies de reliefs rupestres.

description: Référence : PHILIPPES-1-1911-1914-04<br />Domaine : Décor architectural; Architecture<br />
DOI: 10.34816/efa.archives.1180704
title: Philippes-PHILIPPES-1-1911-1914-03-Croquis de reliefs rupestres, photographie de la partie sud de l'acropole.

description: Référence : PHILIPPES-1-1911-1914-03<br />Domaine : Décor architectural; Architecture<br />
DOI: 10.34816/efa.archives.1180708
title: Philippes-PHILIPPES-1-1913-Fouilles de Philippes 1913 (1913).

description: Référence : PHILIPPES-1-1913<br />Domaine : Architecture<br />
DOI: 10.34816/efa.archives.1180717
title: Philippes-PHILIPPES-1-1921-01-Fouilles de Dérékler (1921).

description: Référence : PHILIPPES-1-1921-01<br />Domaine : Architecture; Fouille<br />
DOI: 10.34816/efa.archives.1180709
title: Philippes-PHILIPPES-1-1914-Fouilles de Philippes 1914 (1914).

description: Référence : PHILIPPES-1-1914<br />Domaine : Architecture<br />
DOI: 10.34816/efa.archives.1180716
title: Philippes-PHILIPPES-1-1921-Fouilles de Philippes 1921 (1921).

description: Référence : PHILIPPES-1-1921<br />
DOI: 10.34816/efa.archives.1180715
title: Philippes-PHILIPPES-1-1920-05-Remise des objets découverts pendant les fouilles de L. Renaudin (1920).

description: Référence : PHILIPPES-1-1920-05<br />Domaine : Mobilier<br />
DOI: 10.34816/efa.archives.1180718
title: Philippes-PHILIPPES-1-1921-02-Plan (1921).

description: Référence : PHILIPPES-1-1921-02<br />Domaine : Architecture; Fouille<br />
DOI: 10.34816/efa.archives.1180706
title: Philippes-PHILIPPES-1-1911-1914-05-Croquis du sanctuaire à l'autel, du sanctuaire de Silvain, des rochers de l'acropole.

description: Référence : PHILIPPES-1-1911-1914-05<br />Domaine : Architecture<br />
DOI: 10.34816/efa.archives.1180719
title: Philippes-PHILIPPES-1-1921-03-Fouille du théâtre et déroulement des travaux (1921).

description: Référence : PHILIPPES-1-1921-03<br />Domaine : Architecture; Fouille<br />
DOI: 10.34816/efa.archives.1180694
title: Philippes-PHILIPPES-1-9-Fouilles de Philippes 1921 (1921).

description: Référence : PHILIPPES-1-9<br />Domaine : Architecture; Épigraphie<br />
DOI: 10.34816/efa.archives.1180695
title: Philippes-PHILIPPES-1-10-Fouilles de Philippes (s.d., 1979).

description: Référence : PHILIPPES-1-10<br />Domaine : Épigraphie<br />
DOI: 10.34816/efa.archives.1180712
title: Philippes-PHILIPPES-1-1920-02-Sanctuaires rupestres et déroulement des fouilles (temple-terrasse, relevés d'inscriptions) (1920).

description: Référence : PHILIPPES-1-1920-02<br />Domaine : Architecture; Épigraphie; Fouille<br />
DOI: 10.34816/efa.archives.1180710
title: Philippes-PHILIPPES-1-1920-Fouilles de Philippes 1920 (1920).

description: Référence : PHILIPPES-1-1920<br />
DOI: 10.34816/efa.archives.1180713
title: Philippes-PHILIPPES-1-1920-03-Travaux de Philippes, de Thasos et prospection au mont Pangée (1920).

description: Référence : PHILIPPES-1-1920-03<br />Domaine : Architecture; Fouille<br />
DOI: 10.34816/efa.archives.1180714
title: Philippes-PHILIPPES-1-1920-04-Dégradations commises sur le site de Philippes et expropriation des terrains à Thasos (champ Sotiriadis, terrains de l'agora, Wakouf) (1920).

description: Référence : PHILIPPES-1-1920-04<br />Domaine : Architecture; Fouille<br />
DOI: 10.15493/saeon.egagasini.20241107
title: Velocity profile data collected by PGS during  their 3D surveys between 2023 and 2024. 

description: The dataset consists of physical oceanographic properties such as conductivity, temperature, depth, salinity, density, and water speed collected during 3D geophysical surveys conducted by Petroleum Geo-Services (PGS) on behalf of Searcher Seismic along the west coast of Southern Africa, and velocity profiles were also generated throughout the survey. These surveys were carried out aboard the PGS R/V Ramform Atlas, covering extensive areas within several petroleum licence blocks. The data is organized into 14 CSV files and provides comprehensive insights into the region’s oceanographic conditions. The data sharing was facilitated through the South African Marine Research and Exploration Forum (SAMREF) a Operation Phakisa Oceans Economy Lab project.
DOI: 10.34816/efa.archives.1180689
title: Philippes-PHILIPPES-1-4-Fouilles de Philippes (s.d.).

description: Référence : PHILIPPES-1-4<br />Domaine : Architecture<br />
DOI: 10.15493/saeon.egagasini.20241109
title: Marine fauna sightings during a 3D Survey along the west coast of Southern Africa: Insights from visual monitoring aboard the R.V. Ramform Atlas

description:  This dataset consists of marine fauna sightings collected through visual monitoring during a 3D survey conducted by Petroleum Geo-Services (PGS) on behalf of Searcher Seismic along the west coast of Southern Africa, onboard the R.V. Ramform Atlas. The visual monitoring, which spanned 108 days of dedicated observation, recorded a total of 35 marine fauna sightings. This dataset provides crucial insights into the presence and distribution of marine mammals in the region, significantly contributing to conservation efforts and enhancing our understanding of marine ecosystems. The data sharing was facilitated through the South African Marine Research and Exploration Forum (SAMREF) an Operation Phakisa Oceans Economy Lab project.
DOI: 10.15493/saeon.egagasini.20241110
title: Searcher Seismic Survey: Atlas Source Data

description: Atlas Source Data generated from the 3D seismic survey conducted by Petroleum Geo-Services (PGS) for Searcher Seismic,  along the west coast of Southern Africa, onboard the R.V. Ramform Atlas. The data sharing was facilitated through the South African Marine Research and Exploration Forum (SAMREF) an Operation Phakisa Oceans Economy Lab project. This dataset requires a specific software in order acccess and open the files. For further details, contact us.
DOI: 10.15493/saeon.egagasini.20241108
title: Acoustic Detections of Marine Mammals During a 3D Survey along the west coast of Southern Africa: Insights from Passive Acoustic Monitoring (PAM).

description: This dataset consists of marine mammal acoustic recordings collected through passive monitoring systems, designed to detect and identify marine mammals by analyzing their vocalizations during a 3D survey conducted by Petroleum Geo-Services (PGS) on behalf of Seacher Seismic along the west coast of Southern Africa. The analysis of these recordings provides valuable insights into the presence, behavior, and distribution of marine mammal species across different oceanic regions, with 13 acoustic detections recorded. This dataset plays a key role in advancing conservation efforts and improving our understanding of marine ecosystems. The data sharing was facilitated through the South African Marine Research and Exploration Forum (SAMREF) an Operation Phakisa Oceans Economy Lab project.
DOI: 10.15493/saeon.egagasini.20241112
title: Searcher Seismic Survey: Appendices for survey

description:  A supplementary section that provides additional information and data that is relevant to the 3D seismic survey conducted by Petroleum Geo-Services (PGS) on behalf of Searcher Seismic. This dataset includes pdfs, and excel spreadsheets. The data sharing was facilitated through the South African Marine Research and Exploration Forum (SAMREF), an Operation Phakisa Oceans Economy Lab project.
DOI: 10.34816/efa.archives.1180684
title: Philippes-PHILIPPES-1-1-Fouilles de Philippes (s.d.).

description: Référence : PHILIPPES-1-1<br />
DOI: 10.34816/efa.archives.1180686
title: Philippes-PHILIPPES-1-1-02-Notes sur l'acropole, le théâtre et le temple de Silvain (s.d.).

description: Référence : PHILIPPES-1-1-02<br />Domaine : Architecture<br />
DOI: 10.34816/efa.archives.1180687
title: Philippes-PHILIPPES-1-2-Fouilles de Philippes (s.d.).

description: Référence : PHILIPPES-1-2<br />Domaine : Architecture<br />
DOI: 10.34816/efa.archives.1180688
title: Philippes-PHILIPPES-1-3-Fouilles de Philippes (s.d.).

description: Référence : PHILIPPES-1-3<br />Domaine : Épigraphie<br />
DOI: 10.34816/efa.archives.1180690
title: Philippes-PHILIPPES-1-5-Fouilles de Philippes (s.d.).

description: Référence : PHILIPPES-1-5<br />Domaine : Épigraphie<br />
DOI: 10.34816/efa.archives.1180691
title: Philippes-PHILIPPES-1-6-Fouilles de Philippes (s.d.).

description: Référence : PHILIPPES-1-6<br />Domaine : Épigraphie<br />
DOI: 10.34816/efa.archives.1180693
title: Philippes-PHILIPPES-1-8-Fouilles de Philippes (s.d.).

description: Référence : PHILIPPES-1-8<br />Domaine : Architecture<br />
DOI: 10.34816/efa.archives.1180692
title: Philippes-PHILIPPES-1-7-Fouilles de Philippes (s.d.).

description: Référence : PHILIPPES-1-7<br />Domaine : Épigraphie<br />
DOI: 10.34816/efa.archives.948201
title: Delphes-N841-214-Fronton est remonté au musée, vue d’ensemble

description: Référence : N841-214<br />Publication(s) : FD IV, 8.1, p. 33, fig. 25 et p. 482, fig. 4<br />Domaine : Sculpture<br />
DOI: 10.34816/efa.archives.414
title: Délos-47580-Inscription, compte de l'administration des Hiéropes, face A, partie supérieure

description: Référence : 47580<br />Bibliographie : IG XI 2, 161 A<br />Publication(s) : Et. epig. 4 - Nouveau choix d’inscriptions de Délos /: pl. III<br />Domaine : Épigraphie<br />
DOI: 10.34816/efa.archives.413
title: Délos-47579-Inscription, compte de l'administration des Hiéropes, face A, partie inférieure

description: Référence : 47579<br />Bibliographie : IG XI 2, 161 A<br />Publication(s) : Et. epig. 4 - Nouveau choix d’inscriptions de Délos /: pl. IV<br />Domaine : Épigraphie<br />
DOI: 10.34816/efa.archives.55237
title: Thasos-R2334-003-Sujet : objet, Matériau : bronze os

description: Référence : R2334-003<br />Publication(s) : ÉtThas XII, pl. 82, fig. 1, fig. 121BIS, 122, 123, 124, 125, 126, 127, 128, 129 ; Guide de Thasos p. 300, fig. 265<br />Domaine : Divers<br />
DOI: 10.34816/efa.archives.6835
title: Délos-N8-157-Maison III S, statue en marbre d'Artemis Élaphébole, détail

description: Référence : N8-157<br />Publication(s) : Inédit<br />Période(s) : Hellénistique; Antiquité<br />Domaine : Sculpture<br />
DOI: 10.34816/efa.archives.6836
title: Délos-N8-158-Maison III S, statue en marbre d'Artemis Élaphébole, détail

description: Référence : N8-158<br />Publication(s) : BCH SUPPL. 51, p. 802, fig. 4<br />Période(s) : Hellénistique; Antiquité<br />Domaine : Sculpture<br />
DOI: 10.34816/efa.archives.6837
title: Délos-N8-159-Maison III S, statue en marbre d'Artemis Élaphébole, détail

description: Référence : N8-159<br />Publication(s) : Inédit<br />Période(s) : Hellénistique; Antiquité<br />Domaine : Sculpture<br />
DOI: 10.34816/efa.archives.6838
title: Délos-N8-160-Maison III S, statue en marbre d'Artemis Élaphébole, détail

description: Référence : N8-160<br />Publication(s) : Inédit<br />Période(s) : Hellénistique; Antiquité<br />Domaine : Sculpture<br />
DOI: 10.34816/efa.archives.6839
title: Délos-N8-161-Maison III S, statue en marbre d'Artemis Élaphébole, détail

description: Référence : N8-161<br />Publication(s) : Inédit<br />Période(s) : Hellénistique; Antiquité<br />Domaine : Sculpture<br />
DOI: 10.15468/dl.w6jw3q
title: Occurrence Download

description: A dataset containing 7473 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Champsocephalus gunnari Lönnberg, 1905"
 ]
}

 The dataset includes 7473 records from 52 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0068602-241126133413365/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.34816/efa.archives.6840
title: Délos-N8-162-Maison III S, statue en marbre d'Artemis Élaphébole, détail

description: Référence : N8-162<br />Publication(s) : Inédit<br />Période(s) : Hellénistique; Antiquité<br />Domaine : Sculpture<br />
DOI: 10.34816/efa.archives.6831
title: Délos-N8-153-Maison III S, statue en marbre d'Artemis Élaphébole, détail

description: Référence : N8-153<br />Publication(s) : Inédit<br />Période(s) : Hellénistique; Antiquité<br />Domaine : Sculpture<br />
DOI: 10.34816/efa.archives.6829
title: Délos-N8-151-Maison III S, statue en marbre d'Artemis Élaphébole, détail

description: Référence : N8-151<br />Publication(s) : Inédit<br />Période(s) : Hellénistique; Antiquité<br />Domaine : Sculpture<br />
DOI: 10.15468/dl.dh2hs9
title: Occurrence Download

description: A dataset containing 6 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Raja ackleyi Garman, 1881",
 "HasGeospatialIssue is false",
 "HasCoordinate is true",
 "OccurrenceStatus is Present",
 "Year is greater than or equal to 1900"
 ]
}

 The dataset includes 6 records from 5 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0068603-241126133413365/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.34816/efa.archives.6832
title: Délos-N8-154-Maison III S, statue en marbre d'Artemis Élaphébole, détail

description: Référence : N8-154<br />Publication(s) : BCH SUPPL. 51, p. 813, fig. 1<br />Période(s) : Hellénistique; Antiquité<br />Domaine : Sculpture<br />
DOI: 10.34816/efa.archives.6833
title: Délos-N8-155-Maison III S, statue en marbre d'Artemis Élaphébole, détail

description: Référence : N8-155<br />Publication(s) : Inédit<br />Période(s) : Hellénistique; Antiquité<br />Domaine : Sculpture<br />
DOI: 10.34816/efa.archives.6834
title: Délos-N8-156-Maison III S, statue en marbre d'Artemis Élaphébole, détail

description: Référence : N8-156<br />Publication(s) : Inédit<br />Période(s) : Hellénistique; Antiquité<br />Domaine : Sculpture<br />
DOI: 10.5281/zenodo.7761156
title: FESOM sea ice production for the southern Weddell Sea, 2002-2017

description: Sea ice production data for the southern Weddell Sea from the FESOM simulation. Data is used in the paper:



Stulic, L., Timmermann, R., Paul, S., Zentek, R., Heinemann, G., and Kanzow, T.: Southern Weddell Sea surface freshwater flux modulated by icescape and atmospheric forcing, Ocean Sci., 19, 1791–1808, https://doi.org/10.5194/os-19-1791-2023, 2023.
DOI: 10.34816/efa.archives.1154466
title: Délos-DELOS-2-C-DEL-035-Fouilles de Délos, par Ch. Picard (1910).

description: Référence : DELOS-2-C-DEL-035<br />Domaine : Décor architectural; Petite plastique; Architecture; Topographie; Épigraphie; Mobilier; Fouille; Vase<br />
DOI: 10.6084/m9.figshare.28203209.v1
title: Supplementary Material for: Swallowed topical tacrolimus induces clinical and histological remission in a subset of patients with severe lymphocytic esophagitis

description: Introduction: Lymphocytic esophagitis (LyE) represents a chronic inflammatory disease of the esophagus with low response rates to topical steroids. Thus, novel treatment options such as swallowed topical tacrolimus, particularly for refractory cases, are urgently needed. 
Methods: We retrospectively analyzed patients with LyE enrolled in the Swiss EoE database that received treatment with a swallowed tacrolimus syrup (1mg bid). We compared clinical (VAS 0-10), endoscopic (visual analogue score VAS, Endoscopic Reference Score EREFS) and histological (peak lymphocyte count) disease activity before vs after treatment. 
Results: Out of 17 LyE patients, we identified a total of 7 patients undergoing tacrolimus treatment (4 males, median age 71.3y, IQR, 61.3-76.5, median diagnostic delay of 51.0 months, IQR 24.5-62.0). Six patients had been previously treated with PPI, five with topical and/or systemic steroids. All patients were treated with topical tacrolimus corresponding to 1mg bid (for a median of 13 weeks, IQR 11-15). All Patients had clinically, and histologically active disease at baseline. Topical tacrolimus treatment resulted in histological remission (&lt;30 lymphocytes/hpf) in 3/7 patients (42.9%), while 4/7 patients achieved symptomatic remission (VAS for dysphagia ≤2, 57.1%). Overall, clinical (VAS 5 vs 2, p=0.0625) and endoscopic activity (VAS 5 vs 2, p=0.0625, and EREFS 3 vs 2, p=0.125) decreased. Measurement of tacrolimus trough levels in 4/7 patients (range 2.1-3.9ug/L) revealed some degree of systemic absorption. Mild adverse events to the tacrolimus treatment were seen in two patients (esophageal candidiasis, hyposensitivity around lips). No impact on kidney function was observed during the treatment period.
Conclusion: Topical tacrolimus appears to be a potential treatment option for severe LyE, particularly after failure of PPI and/or topical steroids. Further studies are needed, in particular regarding the optimal galenic formulation to avoid systemic absorption.