cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.6714092.v1
title: Role of the MAPK/cJun NH<sub>2</sub>-Terminal Kinase signaling pathway in starvation-induced autophagy

description: Autophagy is required for cellular homeostasis and can determine cell viability in response to stress. It is established that MTOR is a master regulator of starvation-induced macroautophagy/autophagy, but recent studies have also implicated an essential role for the MAPK8/cJun NH<sub>2</sub>-terminal kinase 1 signal transduction pathway. We found that MAPK8/JNK1 and MAPK9/JNK2 were not required for autophagy caused by starvation or MTOR inhibition in murine fibroblasts and epithelial cells. These data demonstrate that MAPK8/9 has no required role in starvation-induced autophagy. We conclude that the role of MAPK8/9 in autophagy may be context-dependent and more complex than previously considered.
DOI: 10.6084/m9.figshare.6714086
title: ECJ Judges read the morning papers. Explaining the turnaround of European citizenship jurisprudence

description: Recent jurisprudence of the European Court of Justice (ECJ) marks a striking shift towards a more restrictive interpretation of EU citizens’ rights. The Court's turnaround is not only highly relevant for practical debates about ‘Social Europe’ or ‘welfare migration’, but also enlightening from a more general, theoretical viewpoint. Several recent studies on the ECJ have argued that the Court is largely constrained by member state governments’ threats of legislative override and non-compliance. We show that an additional mechanism is necessary to explain the Court's turnaround on citizenship. While the ECJ extended EU citizens’ rights even against strong opposition by member state governments, its recent shift reflects changes in the broader political context, i.e., the politicization of free movement in the European Union (EU). The article theorises Court responsiveness to politicization and demonstrates empirically, how the Court's jurisprudence corresponds with changing public debates about EU citizenship.
DOI: 10.6084/m9.figshare.6714086.v1
title: ECJ Judges read the morning papers. Explaining the turnaround of European citizenship jurisprudence

description: Recent jurisprudence of the European Court of Justice (ECJ) marks a striking shift towards a more restrictive interpretation of EU citizens’ rights. The Court's turnaround is not only highly relevant for practical debates about ‘Social Europe’ or ‘welfare migration’, but also enlightening from a more general, theoretical viewpoint. Several recent studies on the ECJ have argued that the Court is largely constrained by member state governments’ threats of legislative override and non-compliance. We show that an additional mechanism is necessary to explain the Court's turnaround on citizenship. While the ECJ extended EU citizens’ rights even against strong opposition by member state governments, its recent shift reflects changes in the broader political context, i.e., the politicization of free movement in the European Union (EU). The article theorises Court responsiveness to politicization and demonstrates empirically, how the Court's jurisprudence corresponds with changing public debates about EU citizenship.
DOI: 10.6084/m9.figshare.6714083
title: Distance, weight and transportation decision data of drone.xlsx

description: The data used are given as the distances of 315 different regions and the weights of the products to be transported to these zones. The data are simulated taking into account the maximum distance the drone can carry (9 km) and the maximum weight the drone can carry (890 grams). In addition, these values ​​have been set as minimums for distance from the vehicle, short distances of 1.7 km, and less than 300 grams of material for carriage. According to the model, "continue" or 1 value is assigned to the products according to the distance-weight values determined to be transported from the first station, and "stop" or 0 value is assigned to the products determined to be transported from the second station. <br>
DOI: 10.6084/m9.figshare.6714074
title: Public voices in the heavenly chorus? Group type bias and opinion representation

description: While strong voices in the academic literature and real-world politics regard interest groups as biased representatives of the public, we know little about the scope and consequences of such biases for democratic governance. We conduct the first cross-national comparison of group and public preferences analyzing a new dataset of 50 issues in five West European countries. Despite the negative image of interest groups in politics, we find that their positions are in line with public opinion more than half the time. Moreover, while firms and business associations enjoy weaker support for their positions among citizens than public interest groups, they still enjoy the backing of a sizable share of the public. Additionally, we find no general pattern that communities with low interest group diversity are less likely to represent public opinion. Our findings have implications for democratic governance and discussions of how to conceptualize and measure biases in interest representation.
DOI: 10.6084/m9.figshare.6714074.v1
title: Public voices in the heavenly chorus? Group type bias and opinion representation

description: While strong voices in the academic literature and real-world politics regard interest groups as biased representatives of the public, we know little about the scope and consequences of such biases for democratic governance. We conduct the first cross-national comparison of group and public preferences analyzing a new dataset of 50 issues in five West European countries. Despite the negative image of interest groups in politics, we find that their positions are in line with public opinion more than half the time. Moreover, while firms and business associations enjoy weaker support for their positions among citizens than public interest groups, they still enjoy the backing of a sizable share of the public. Additionally, we find no general pattern that communities with low interest group diversity are less likely to represent public opinion. Our findings have implications for democratic governance and discussions of how to conceptualize and measure biases in interest representation.
DOI: 10.6084/m9.figshare.6713879
title: ESM S21 from <i>Waptia fieldensis</i> Walcott, a mandibulate arthropod from the middle Cambrian Burgess Shale

description: Waptia fieldensis, matrix of characters used in the present cladistic analysis.
DOI: 10.6084/m9.figshare.6713879.v1
title: ESM S21 from <i>Waptia fieldensis</i> Walcott, a mandibulate arthropod from the middle Cambrian Burgess Shale

description: Waptia fieldensis, matrix of characters used in the present cladistic analysis.
DOI: 10.6084/m9.figshare.6713873
title: Data for figure 3 from Impact of the springtail's cuticle nanotopography on bioadhesion and biofilm formation <i>in vitro</i> and in the oral cavity

description: Springtails (Collembola) have a nano-structured cuticle. To evaluate and to understand anti-biofouling properties of springtail cuticles’ morphology under different conditions, springtails, shed cuticles and cuticle replicates were studied after incubation with protein solutions and bacterial cultures using common <i>in vitro</i> models. In a second step, they were exposed to human oral environment <i>in situ</i> in order to explore potential application in dentistry. <i>In vitro</i>, the cuticular structures were found to resist wetting by albumin solutions for up to 3 h and colonization by <i>Staphylococcus epidermidis</i> was inhibited. When exposed in the oral cavity, initial pellicle formation was of high heterogeneity: parts of the surface were coated by adsorbed proteins, others remained uncoated but exhibited locally attached, ‘bridging’, proteinaceous membranes spanning across cavities of the cuticle surface; this unique phenomenon was observed for the first time. Also the degree of bacterial colonization varied considerably. In conclusion, the springtail cuticle partially modulates bioadhesion in the oral cavity in a unique and specific manner, but it has no universal effect. Especially after longer exposure, the nano-textured surface of springtails is masked by the pellicle, resulting in subsequent bacterial colonization, and, thus, cannot effectively avoid bio-adhesion in the oral cavity comprehensively. Nevertheless, the observed phenomena offer valuable information and new perspectives for the development of antifouling surfaces applicable in the oral cavity.
DOI: 10.6084/m9.figshare.6713873.v1
title: Data for figure 3 from Impact of the springtail's cuticle nanotopography on bioadhesion and biofilm formation <i>in vitro</i> and in the oral cavity

description: Springtails (Collembola) have a nano-structured cuticle. To evaluate and to understand anti-biofouling properties of springtail cuticles’ morphology under different conditions, springtails, shed cuticles and cuticle replicates were studied after incubation with protein solutions and bacterial cultures using common <i>in vitro</i> models. In a second step, they were exposed to human oral environment <i>in situ</i> in order to explore potential application in dentistry. <i>In vitro</i>, the cuticular structures were found to resist wetting by albumin solutions for up to 3 h and colonization by <i>Staphylococcus epidermidis</i> was inhibited. When exposed in the oral cavity, initial pellicle formation was of high heterogeneity: parts of the surface were coated by adsorbed proteins, others remained uncoated but exhibited locally attached, ‘bridging’, proteinaceous membranes spanning across cavities of the cuticle surface; this unique phenomenon was observed for the first time. Also the degree of bacterial colonization varied considerably. In conclusion, the springtail cuticle partially modulates bioadhesion in the oral cavity in a unique and specific manner, but it has no universal effect. Especially after longer exposure, the nano-textured surface of springtails is masked by the pellicle, resulting in subsequent bacterial colonization, and, thus, cannot effectively avoid bio-adhesion in the oral cavity comprehensively. Nevertheless, the observed phenomena offer valuable information and new perspectives for the development of antifouling surfaces applicable in the oral cavity.
DOI: 10.6084/m9.figshare.6713867
title: Low carbon scenarios and policies for the power sector in Botswana

description: The Government of Botswana has pledged a nationally determined contribution (NDC) as a commitment to the Paris Agreement. For the power sector, the NDC states that the government expects renewable energy (RE) to meet 25% of peak electricity demand by 2030. However, due to high initial cost of RE technologies, the government plans to maintain a coal-based power system in the future. Therefore, the purpose of this paper is to examine Botswana’s national plan from an economic perspective, using scenario and cost analysis, to explore the possibility of the power sector’s low carbon transition in the light of Botswana’s NDC. Five scenarios are designed to reflect a range of investment cost changes of RE technologies. While most scenarios only achieve 19% (P3, P4 and P5) and 54% (P6) of the NDC’s power sector target, the P7 scenario far exceeds the goal by achieving 188% of the NDC target. Furthermore, as the difference of levelized cost of electricity among the scenarios is minimal, the P7 scenario is the most attractive pathway for the government. Even for other scenarios, the government should still deploy the suggested capacity of solar photovoltaic (PV) as it is both economically and socially beneficial in the long term. However, in these cases, the government’s political will to meet the NDC’s power sector target and to promote the solar PV industry will be critical in designing future power sector policies. <b>Key policy insights</b>Model results show coal as the cheapest resource for electricity generation in Botswana up to 2030, but the cost competitiveness of solar photovoltaic (PV) against coal will continue to increase over time.It is economically and socially beneficial to adjust the current national plan and substitute some share of coal with solar PV in the future energy mix.Government support is critical in achieving the power sector’s NDC target, as cost reduction of solar PV alone does not guarantee success.Encouraging independent power producers (IPP) with financial support mechanisms would be a suitable business model for developing the renewable energy industry. Model results show coal as the cheapest resource for electricity generation in Botswana up to 2030, but the cost competitiveness of solar photovoltaic (PV) against coal will continue to increase over time. It is economically and socially beneficial to adjust the current national plan and substitute some share of coal with solar PV in the future energy mix. Government support is critical in achieving the power sector’s NDC target, as cost reduction of solar PV alone does not guarantee success. Encouraging independent power producers (IPP) with financial support mechanisms would be a suitable business model for developing the renewable energy industry.
DOI: 10.6084/m9.figshare.6713867.v1
title: Low carbon scenarios and policies for the power sector in Botswana

description: The Government of Botswana has pledged a nationally determined contribution (NDC) as a commitment to the Paris Agreement. For the power sector, the NDC states that the government expects renewable energy (RE) to meet 25% of peak electricity demand by 2030. However, due to high initial cost of RE technologies, the government plans to maintain a coal-based power system in the future. Therefore, the purpose of this paper is to examine Botswana’s national plan from an economic perspective, using scenario and cost analysis, to explore the possibility of the power sector’s low carbon transition in the light of Botswana’s NDC. Five scenarios are designed to reflect a range of investment cost changes of RE technologies. While most scenarios only achieve 19% (P3, P4 and P5) and 54% (P6) of the NDC’s power sector target, the P7 scenario far exceeds the goal by achieving 188% of the NDC target. Furthermore, as the difference of levelized cost of electricity among the scenarios is minimal, the P7 scenario is the most attractive pathway for the government. Even for other scenarios, the government should still deploy the suggested capacity of solar photovoltaic (PV) as it is both economically and socially beneficial in the long term. However, in these cases, the government’s political will to meet the NDC’s power sector target and to promote the solar PV industry will be critical in designing future power sector policies. <b>Key policy insights</b>Model results show coal as the cheapest resource for electricity generation in Botswana up to 2030, but the cost competitiveness of solar photovoltaic (PV) against coal will continue to increase over time.It is economically and socially beneficial to adjust the current national plan and substitute some share of coal with solar PV in the future energy mix.Government support is critical in achieving the power sector’s NDC target, as cost reduction of solar PV alone does not guarantee success.Encouraging independent power producers (IPP) with financial support mechanisms would be a suitable business model for developing the renewable energy industry. Model results show coal as the cheapest resource for electricity generation in Botswana up to 2030, but the cost competitiveness of solar photovoltaic (PV) against coal will continue to increase over time. It is economically and socially beneficial to adjust the current national plan and substitute some share of coal with solar PV in the future energy mix. Government support is critical in achieving the power sector’s NDC target, as cost reduction of solar PV alone does not guarantee success. Encouraging independent power producers (IPP) with financial support mechanisms would be a suitable business model for developing the renewable energy industry.
DOI: 10.25375/uct.6713852.v2
title: Postgraduate students as OER capacitators

description: A comprehensive theoretical, legal and practical basis for OER has been developed over the past fifteen years, supported by the expansion of open source curation platforms and the work of advocacy groups and international bodies. OER’s potential has been sufficiently documented; the question remains how best to support, integrate and normalise OER activity within the academic community in a sustainable fashion. This paper draws on the experiences of the Vice Chancellor’s Open Educational Resources Adaptation project in the University of Cape Town, which explored whether postgraduate students, with their blend of developing subject knowledge, greater time resources, and experience of teaching artefacts from both a learner’s and educator’s perspective, may be a valuable resource for lecturers or institutions eager to engage in OER but lacking the requisite support structures. It was found that postgraduates were best employed as capacitating agents, focusing on the non-pedagogical elements of OER adaptation.<br>This article was first published in Open Praxis, vol.9 issue 2, pp. 223-234 under a CC BY 4.0 licence.<br>
DOI: 10.6084/m9.figshare.6713837
title: tokenizer and word embeddings

description: Word tokenizer and precomputed word embeddings<br>
DOI: 10.6084/m9.figshare.6713834
title: BER_versus_Rho_FSPJ.m

description: Simulate the BER of DCSK system versus EbN0, Pj/Ps, and the duty cycle of pulse jamming, respectively.
DOI: 10.6084/m9.figshare.6713834.v1
title: BER_versus_Rho_FSPJ.m

description: Simulate the BER of DCSK system versus EbN0, Pj/Ps, and the duty cycle of pulse jamming, respectively.
DOI: 10.6084/m9.figshare.6713714
title: DeepGMAP-data-light.tar.gz

description: A light version of data for DeepGMAP. It contains mouse genome files, a subset of DNase-seq data for training, and trained variables.
DOI: 10.6084/m9.figshare.6713714.v1
title: DeepGMAP-data-light.tar.gz

description: A light version of data for DeepGMAP. It contains mouse genome files, a subset of DNase-seq data for training, and trained variables.
DOI: 10.6084/m9.figshare.6713702
title: Base-pairing probability in the microRNA stem region affects the binding and editing specificity of human A-to-I editing enzymes ADAR1-p110 and ADAR2

description: Adenosine deaminases acting on RNA (ADARs) catalyze the deamination of adenosine (A) to inosine (I). A-to-I RNA editing targets double-stranded RNA (dsRNA), and increases the complexity of gene regulation by modulating base pairing-dependent processes such as splicing, translation, and microRNA (miRNA)-mediated gene silencing. This study investigates the genome-wide binding preferences of the nuclear constitutive isoforms ADAR1-p110 and ADAR2 on human miRNA species by RNA immunoprecipitation of ADAR-bound small RNAs (RIP-seq). Our results suggest that secondary structure predicted by base-pairing probability in the mainly double-stranded region of a pre-miRNA or mature miRNA duplex may determine ADAR isoform preference for binding distinct subpopulations of miRNAs. Furthermore, we identify 31 unique editing sites with statistical significance, 19 sites of which are novel editing sites. Editing sites are enriched in the seed region responsible for target recognition by miRNAs, and isoform-specific nucleotide motifs in the immediate vicinity and opposite of editing sites are consistent with previous studies, and further reveal that ADAR2 may edit A/C bulges more frequently than ADAR1-p110 in the context of miRNA.
DOI: 10.6084/m9.figshare.6713702.v1
title: Base-pairing probability in the microRNA stem region affects the binding and editing specificity of human A-to-I editing enzymes ADAR1-p110 and ADAR2

description: Adenosine deaminases acting on RNA (ADARs) catalyze the deamination of adenosine (A) to inosine (I). A-to-I RNA editing targets double-stranded RNA (dsRNA), and increases the complexity of gene regulation by modulating base pairing-dependent processes such as splicing, translation, and microRNA (miRNA)-mediated gene silencing. This study investigates the genome-wide binding preferences of the nuclear constitutive isoforms ADAR1-p110 and ADAR2 on human miRNA species by RNA immunoprecipitation of ADAR-bound small RNAs (RIP-seq). Our results suggest that secondary structure predicted by base-pairing probability in the mainly double-stranded region of a pre-miRNA or mature miRNA duplex may determine ADAR isoform preference for binding distinct subpopulations of miRNAs. Furthermore, we identify 31 unique editing sites with statistical significance, 19 sites of which are novel editing sites. Editing sites are enriched in the seed region responsible for target recognition by miRNAs, and isoform-specific nucleotide motifs in the immediate vicinity and opposite of editing sites are consistent with previous studies, and further reveal that ADAR2 may edit A/C bulges more frequently than ADAR1-p110 in the context of miRNA.
DOI: 10.6084/m9.figshare.6713597
title: Tuboperitoneal fistula, ectopic pregnancy, and remnants of fallopian tube: a confocal microtomography analysis and 3D reconstruction of human fallopian tube pathologies

description: <b>Objective:</b> The aim of this study was to provide a three-dimensional (3D) microscopic reconstruction of morphological modifications of the fallopian tube (FT) following surgical sterilization (including tuboperitoneal fistula) and ectopic pregnancy (EP) using confocal microtomography (micro-CT). <b>Methods:</b> Six specimens of FT from elective and emergency surgeries were selected: three remnants of the FT (RFT) from surgical sterilization, including one presenting tuboperitoneal fistula, and three FTs with EP. The specimens were fixed in formalin and stained with Lugol solution. Micro-CT studies were conducted on the specimens using protocols adapted from biological studies. <b>Results:</b> Three RFTs from surgical sterilization and three FTs affected by EPs were successfully scanned using micro-CT. There was good contrast impregnation, allowing tissue segmentation and analysis of different sections of the FTs. Three FT specimens from EP exhibited considerable distortion of the tubal anatomy, mainly from the blood clot in the tubal abortion. Three RFT specimens exhibited some features observed in traditional microscopy, such as tubal distension and loss of normal anatomical characteristics of a normal FT, and indicated the presence of a tuboperitoneal fistula in one of the three specimens. <b>Conclusion:</b> Micro-CT can identify morphological characteristics of FT pathologies previously described in a microscopic scale, with tissue contrast and the possibility of 3D reconstruction. Micro-CT is also useful in guiding traditional sectioning of specimens for histopathological studies.