cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.31157407.v1
title: Supplementary Material for: The Study of Intelligent Scoring Tools for Acute Posterior Circulation Ischemic Stroke

description: Background and purpose
Posterior Circulation Acute Stroke Prognosis Early Computed Tomography Scores 
(PC-ASPECTS) is crucial for diagnosing, treating, and predicting the prognosis of acute ischemic stroke in patients with posterior circulation involvement. However, physicians take longer to score patients' pc-ASPECTS and inter-rater reliability is low among different physicians. To address this issue, we developed an intelligent scoring model using artificial intelligence technology to enhance the accuracy and consistency of these scores.
Methods
Retrospective clinical and imaging data from multiple stroke centers were used to train and validate a convolutional neural network (CNN)-based model. The model identified early ischemic changes in predefined posterior circulation regions. Performance was evaluated using standard metrics (e.g., AUC, sensitivity, specificity) and compared to manual scoring by clinicians.
Results
A total of 674 patients with complete data were included in the study, 536 patients (mean age, 56 years ± 12 [SD]; 298 [55.6%] female) were included for model development (training: 300; validation: 129; and internal test set: 107). Another 138 patients (mean age, 59 years ± 14; 90 [65.2%] female) were included in an external test set to evaluate model’s performance and generalizability. The PC-ASPECTS intelligent scoring model demonstrated strong discriminative ability across all regions (AUC range: 0.687–0.805). It significantly improved inter-rater consistency (kappa: 0.317 to 0.711) and reduced scoring time compared to clinicians (2–5 seconds vs. 25–90 seconds, p&lt; 0.05).
Conclusions
The PC-ASPECTS intelligent scoring model developed in this study demonstrated commendable performance. Utilizing this prediction model, the consistency of PC-ASPECTS scoring among clinical physicians was improved and efficiency was significantly enhanced.
DOI: 10.5061/dryad.vk002fn
title: Data from: Female-female competition leads to female-biased sex allocation and dimorphism in brood sex composition in a gall-forming aphid

description: 1. Sex allocation in animals is predicted to be skewed from a 1:1 ratio if
 sons and daughters yield different marginal fitness returns per unit
 maternal investment. 2. We tested this prediction using the gall-forming
 aphid Tetraneura sorini, in which lethal fighting is common among females,
 whereas male-male competition is moderate. Mothers (autumnal winged
 females) parthenogenetically produce females and males in their abdomen
 and can control their sizes and numbers. The females and males do not feed
 after birth. After mating, females produce single eggs, from which only
 females (foundresses) hatch and fight intensely with one another during
 the galling process. 3. Larger-sized foundresses have overwhelming
 advantages in fighting. If mothers invest more in individual females, they
 can produce larger foundresses (granddaughters), which yields greater
 fitness returns. This situation is contrary to the original
 Trivers–Willard hypothesis. Thus, we predicted that more fecund mothers in
 this species would invest more in females. 4. The cost of producing one
 female was found to be 3.0-3.2 times the cost of producing one male.
 Population sex ratios were male-biased (54.8%–58.2% male), but population
 sex allocation was highly female biased (68%–72% females). Larger mothers
 biased their progeny sex ratios more towards females and produced larger
 females, thus supporting our prediction. 5. Mothers produced two types of
 brood: all-female broods and mixed-sex broods. Mothers with an all-female
 brood produced larger females than those with a mixed-sex brood, thereby
 offering their granddaughters (foundresses) an advantage in fighting. 6.
 Local mate competition has been postulated to explain female-biased
 population sex allocation in gall-forming aphids. However, we concluded
 that competition among foundresses has led to the evolution of
 female-biased sex allocation at the population level and dimorphism in
 brood sex composition.
description: Brood composition in
 winged females and their body sizeThis data include the
 brood composition of winged mothers collected in the wild and their
 forewing lengths. The indices of "MaternalInvestment" and
 "investment_in_daughters" are described in the
 text.wild2001+2017.csvBrood composition in winged females rearedThis data include the brood composition (sons and daughters) of winged females reared in the laboratory. Winged females were reared clonally, so that clone identification is indicated. The forewing lengths of the females are also shown.rearing clones.csv
DOI: 10.6084/m9.figshare.31157410
title: Supplementary Material for: Successful Treatment of Refractory Erythroderma With Abrocitinib：A Case Report

description: Aim: To report the successful use of abrocitinib in a patient with erythroderma unresponsive to conventional therapies, addressing the current gap in published evidence for its use in this condition.
Methods: We describe a case of refractory erythroderma in an adult who had failed treatment with glucocorticoids, immunosuppressants, and biologics. The patient was initiated on abrocitinib therapy, initially in combination with glucocorticoids to manage the acute flare.
Results: Treatment with abrocitinib resulted in a marked reduction in erythema and associated symptoms. Notably, the patient experienced hair regrowth and was successfully tapered off glucocorticoids. No recurrence of erythroderma or significant adverse events were observed during a six-month follow-up period.
Conclusion: This case suggests that abrocitinib may represent a valuable treatment option for patients with erythroderma refractory to conventional therapies. Further studies are warranted to evaluate its efficacy and safety in a larger cohort.
DOI: 10.6084/m9.figshare.31157410.v1
title: Supplementary Material for: Successful Treatment of Refractory Erythroderma With Abrocitinib：A Case Report

description: Aim: To report the successful use of abrocitinib in a patient with erythroderma unresponsive to conventional therapies, addressing the current gap in published evidence for its use in this condition.
Methods: We describe a case of refractory erythroderma in an adult who had failed treatment with glucocorticoids, immunosuppressants, and biologics. The patient was initiated on abrocitinib therapy, initially in combination with glucocorticoids to manage the acute flare.
Results: Treatment with abrocitinib resulted in a marked reduction in erythema and associated symptoms. Notably, the patient experienced hair regrowth and was successfully tapered off glucocorticoids. No recurrence of erythroderma or significant adverse events were observed during a six-month follow-up period.
Conclusion: This case suggests that abrocitinib may represent a valuable treatment option for patients with erythroderma refractory to conventional therapies. Further studies are warranted to evaluate its efficacy and safety in a larger cohort.
DOI: 10.5061/dryad.22v00
title: Data from: Courtship song preferences in female zebra finches are shaped by developmental auditory experience

description: The performance of courtship signals provides information about the
 behavioural state and quality of the signaller, and females can use such
 information for social decision-making (e.g. mate choice). However,
 relatively little is known about the degree to which the perception of and
 preference for differences in motor performance are shaped by
 developmental experiences. Furthermore, the neural substrates that
 development could act upon to influence the processing of performance
 features remains largely unknown. In songbirds, females use song to
 identify males and select mates. Moreover, female songbirds are often
 sensitive to variation in male song performance. Consequently, we
 investigated how developmental exposure to adult male song affected
 behavioural and neural responses to song in a small, gregarious songbird,
 the zebra finch. Zebra finch males modulate their song performance when
 courting females, and previous work has shown that females prefer the
 high-performance, female-directed courtship song. However, unlike females
 allowed to hear and interact with an adult male during development,
 females reared without developmental song exposure did not demonstrate
 behavioural preferences for high-performance courtship songs.
 Additionally, auditory responses to courtship and non-courtship song were
 altered in adult females raised without developmental song exposure. These
 data highlight the critical role of developmental auditory experience in
 shaping the perception and processing of song performance.
description: EGR1_dataNumber of EGR1 neurons/mm2 in the NCM, CMM and IC.preference_score_by_maleIDAverage preference scores of all females tested on each male stimulus.preference_scores_all_femalesraw data for call back preference tests for normally-reared and song-naive females tested on stimuli from different malespreference_score_vs_song_measuresPercent difference for measures of song between courtship and non-courtship singing. Measures include the number of introductory notes and motifs, syllable entropy, CV of the fundamental frequency and song tempo (motif duration).
DOI: 10.6084/m9.figshare.31157413
title: Supplementary Material for: Associations Between Cumulative Social Determinants of Health and Stroke Prevalence in U.S. Adults: NHANES 2005–2018

description: Abstract
Background: Social determinants of health (SDoH) are increasingly recognized as key contributors to stroke prevalence, yet few studies have examined their cumulative impact. This study aimed to evaluate the associations between multiple SDoH and stroke prevalence, and identify the primary drivers of cumulative social disadvantage.
Methods: We analyzed data from 26703 participants in the 2005–2018 NHANES cycles. Stroke history was self–reported. Eight SDoH indicators—including income, education, employment, food security, housing stability, marital status, healthcare access, and insurance coverage—were assessed. Associations with stroke were examined using survey-weighted logistic regression. A weighted quantile sum (WQS) index was constructed from six of these indicators (excluding marital status and healthcare access) to evaluate the cumulative effect of SDoH and to determine the relative contribution of each factor.
Results: Of the study population, 992 (2.6%) reported a history of stroke. Low income, unemployment, food insecurity, and rental housing were significantly associated with stroke prevalence. WQS analysis demonstrated a strong cumulative association between adverse SDoH and stroke (OR = 4.20, 95% CI: 3.24–5.44, P &lt; 0.001), with food insecurity (weight = 0.33), family poverty income ratio (0.33), and housing status (0.20) contributing the most. Subgroup and sensitivity analyses confirmed the robustness of these associations across age, sex, and racial/ethnic groups.
Conclusion: Cumulative social disadvantage, particularly food insecurity, low family poverty income ratio, and disadvantaged housing status, is strongly associated with stroke prevalence. Interventions addressing these key social determinants may help reduce stroke burden and underscore the importance of considering multiple SDoH in preventive strategies.
DOI: 10.6084/m9.figshare.31157413.v1
title: Supplementary Material for: Associations Between Cumulative Social Determinants of Health and Stroke Prevalence in U.S. Adults: NHANES 2005–2018

description: Abstract
Background: Social determinants of health (SDoH) are increasingly recognized as key contributors to stroke prevalence, yet few studies have examined their cumulative impact. This study aimed to evaluate the associations between multiple SDoH and stroke prevalence, and identify the primary drivers of cumulative social disadvantage.
Methods: We analyzed data from 26703 participants in the 2005–2018 NHANES cycles. Stroke history was self–reported. Eight SDoH indicators—including income, education, employment, food security, housing stability, marital status, healthcare access, and insurance coverage—were assessed. Associations with stroke were examined using survey-weighted logistic regression. A weighted quantile sum (WQS) index was constructed from six of these indicators (excluding marital status and healthcare access) to evaluate the cumulative effect of SDoH and to determine the relative contribution of each factor.
Results: Of the study population, 992 (2.6%) reported a history of stroke. Low income, unemployment, food insecurity, and rental housing were significantly associated with stroke prevalence. WQS analysis demonstrated a strong cumulative association between adverse SDoH and stroke (OR = 4.20, 95% CI: 3.24–5.44, P &lt; 0.001), with food insecurity (weight = 0.33), family poverty income ratio (0.33), and housing status (0.20) contributing the most. Subgroup and sensitivity analyses confirmed the robustness of these associations across age, sex, and racial/ethnic groups.
Conclusion: Cumulative social disadvantage, particularly food insecurity, low family poverty income ratio, and disadvantaged housing status, is strongly associated with stroke prevalence. Interventions addressing these key social determinants may help reduce stroke burden and underscore the importance of considering multiple SDoH in preventive strategies.
DOI: 10.5061/dryad.k648s
title: Data from: Splicing factor SF3B1K700E mutant dysregulates erythroid differentiation via aberrant alternative splicing of transcription factor TAL1

description: More than 60% of myeloid dysplasia syndrome (MDS) contains mutations in
 genes encoding for splicing factors such as SF3B1, U2AF, SRSF2 and ZRSR2.
 Mutations in SF3B1 are associated with 80% cases of refractory anemia with
 ring sideroblast (RARS), a subtype of MDS. SF3B1K700E is the most
 frequently mutated site among mutations on SF3B1. Yet the molecular
 mechanisms on how mutations of splicing factors lead to defective
 erythropoiesis are not clear. SF3B1K700E mutant binds to an RNA binding
 protein, RBM15, stronger than the wild type SF3B1 protein in
 co-immunoprecipitation assays. In addition, K700E mutant alters the RNA
 splicing of transcription factors TAL1 and GATA1. Via alternative RNA
 splicing, a novel short TAL1 transcript variant (TAL1s) is generated.
 Enhanced interaction between SF3B1 and RBM15 promotes the production of
 full-length TAL1 (TAL1fl) mRNA, while reduction of RBM15 protein level via
 PRMT1-mediated degradation pathway changes TAL1s/TAL1fl ratio in favor of
 TAL1s. TAL1s contains the helix-loop-helix DNA binding domain but not the
 N terminal region upstream of the DNA binding domain. The TAL1s protein
 loses its interaction with ETO2, which represses early erythropoiesis. In
 this vein, overexpression of TAL1s stimulates the transcription of
 β-hemoglobin in human leukemia K562 cells and promotes erythroid
 differentiation of human cord blood CD34+ cells cultured in
 erythropoietin-containing medium. Therefore, mutations of SF3B1 may block
 erythropoiesis via dysregulation of alternative RNA splicing of
 transcription factor TAL1, and targeting PRMT1 may alleviate the anemic
 symptoms in MDS patients.
description: raw data for charts in
 figuresThis file contains real
 time PCR data for all the figures and western blot band quantification in
 figure 2.support
 information.xlsx
DOI: 10.5061/dryad.dj6gq
title: Data from: In situ warming strengthens trophic cascades in a coastal food web

description: Global warming may affect most organisms and their interactions. Theory
 and simple mesocosm experiments suggest that consumer top–down control
 over primary producer biomass should strengthen with warming, since
 consumer respiration increases faster with warming than plant
 photosynthesis. However, these predictions have so far not been tested on
 natural communities that have experienced warming over many generations.
 Natural systems display a higher diversity, heterogeneity and complexity
 than mesocosms, which could alter predicted effects of warming. Here we
 used an artificially heated part of the northern Baltic Sea (the Forsmark
 Biotest basin) to test how warming influences trophic interactions in a
 shallow coastal food web with four trophic levels: omnivorous fish,
 invertivorous fish, herbivorous invertebrates, and filamentous macroalgae.
 Monitoring of fish assemblages over six years showed that small
 invertivorous fish (gobiids, sticklebacks and minnows) were much less
 abundant in the heated basin than in unheated references areas. Stomach
 content analyses of the dominating omnivorous fish – Eurasian perch Perca
 fluviatilis – revealed a strikingly different diet within and outside the
 Biotest basin; gammarid crustaceans were the dominating prey at heated
 sites, whereas invertivorous fish (e.g. gobiids) dominated at unheated
 sites. A 45-day cage experiment showed that fish exclusion did not affect
 the biomass of algal herbivores (gastropods and gammarids), but reduced
 algal biomass in heated sites (but not unheated). This suggests that
 warming induced a trophic cascade from fish to algae, and that this effect
 was mediated by predator-induced changes in herbivore behavior, rather
 than number. Overall, our study suggests that warming has effectively
 shrunk the food chain from four to three trophic levels (algae, gammarids
 and perch), which have benefitted the primary producers by reducing
 grazing pressure. Consequently, warming appears to have restructured this
 coastal food web through a combination of direct (physiological) and
 indirect (species interactions) effects.
description: Data from the cage
 experiment and the fish surveyFish abundances data
 over six years, inside and outside the biotest basin. Stomach content data
 of perch. Biomass data of gastropods, gammarids and algae from the cage
 experiment. Macrofauna community data. Algal community data. Fish
 contamination data from the cage experiment. Wave exposure data from the
 cage experiment. Light measurements from the cage
 experiment.Data cage
 experiment.xlsx
DOI: 10.5061/dryad.855kh
title: Data from: Evolution of male coloration during a post-pleistocene radiation of Bahamas mosquitofish (Gambusia hubbsi)

description: Sexual signal evolution can be complex because multiple factors influence
 the production, transmission, and reception of sexual signals, as well as
 receivers’ responses to them. To grasp the relative importance of these
 factors in generating signal diversity, we must simultaneously investigate
 multiple selective agents and signaling traits within a natural system. We
 use the model system of the radiation of Bahamas mosquitofish (Gambusia
 hubbsi) inhabiting blue holes to test the effects of resource
 availability, male body size and other life-history traits, key aspects of
 the transmission environment, sex ratio, and predation risk on variation
 in multiple male color traits. Consistent with previous work examining
 other traits in this system, several color traits have repeatedly diverged
 between predation regimes, exhibiting greater elaboration in the absence
 of predators. However, other factors proved influential as well, with
 variation in resource levels, body size, relative testes size, and
 background water color being especially important for several color
 traits. For one prominent signaling trait, orange dorsal fins, we further
 confirmed a genetic basis underlying population differences using a
 laboratory common-garden experiment. We illustrate a promising approach
 for gaining a detailed understanding of the many contributing factors in
 the evolution of multivariate sexual signals.
description: BlueHoleCombinedData_Dryadlab males_Dryad
DOI: 10.5061/dryad.n7t76
title: Data from: A shortage of males causes female reproductive failure in yellow ground squirrels

description: Sexual conflict theory suggests that female breeding success is strongly
 influenced by individual life history and environmental conditions and is
 much less affected by mate availability. Female mating failure due to a
 shortage of males remains poorly studied and understood. We present data
 on the effects of male availability on female breeding success in a wild
 colony of yellow ground squirrels (Spermophilus fulvus). A female’s
 probability of breeding increased with the local density of males and was
 higher with higher male-biased operational sex ratio (OSR) but was
 independent of local female density, female age, and body condition, which
 are factors commonly assumed to influence female reproduction. The
 positive effect of male availability (as measured by OSR) on female
 breeding success was consistent across the years, and we conclude that
 male limitation contributes to female mating failure. This pattern, which
 is not commonly recorded in species with conventional sex roles, can be
 explained by a combination of sociodemographic and life history traits
 (sex differences in age of maturation, female-skewed adult sex ratio and
 seasonally varying OSR, solitary living at low population density, and low
 mobility of females combined with mate-searching tactics of males) that
 are not confined to S. fulvus. Our findings indicate that the role of
 female mating failure (due to a shortage of males) in shaping mammalian
 life history may be underestimated.
description: Female reproduction in
 ground squirrel Vasilieva Tchabovskydata for female reproduction in
 S fulvus SA.xlsx
DOI: 10.5061/dryad.85641
title: Data from: Negative plant-phyllosphere feedbacks in native Asteraceae hosts – a novel extension of the plant-soil feedback framework

description: Over the past 25 years, the plant-soil feedback (PSF) framework has
 catalyzed our understanding of how belowground microbiota impact plant
 fitness and species coexistence. Here, we apply a novel extension of this
 framework to microbiota associated with aboveground tissues, termed
 ‘plant-phyllosphere feedback (PPFs)’. In parallel greenhouse experiments,
 rhizosphere and phyllosphere microbiota of con- and heterospecific hosts
 from four species were independently manipulated. In a third experiment,
 we tested the combined effects of soil and phyllosphere feedback under
 field conditions. We found that three of four species experienced weak
 negative PSF whereas, in contrast, all four species experienced strong
 negative PPFs. Field-based feedback estimates were highly negative for all
 four species, though variable in magnitude. Our results suggest that
 phyllosphere microbiota, like rhizosphere microbiota, can potentially
 mediate plant species coexistence via negative feedbacks. Extension of the
 PSF framework to the phyllosphere is needed to more fully elucidate
 plant-microbiota interactions.
description: WhitakerEtAl2017ELE_dataData used to perform all analyses and create all figures in the published article Whitaker et al. 2017 Ecology Letters.2015_AsterFB_CSVs.zip2015_AsterFB_sascode_SASsSAS code used to perform all statistical analyses in the published article Whitaker et al. 2017 Ecology Letters.2015_AsterFB_code&filesR Code used to create all data figures in the published article Whitaker et al. 2017 Ecology Letters.