cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.14268433.v1
title: Reliability and geotechnical safety applied to deep foundations in precast concrete piles - case study

description: Abstract The Brazilian standard pertinent to the design and execution of foundations, NBR 6122/2019, establishes that the safety inspection of foundations of a given project must be conducted based on compliance with specified safety factors. Safety factor verification is imperative to meet regulatory requirements; however, it is not enough to guarantee the safety of a foundation. As there is variability in the resistance and solicitation of the piles that make up a foundation, each safety factor value reflects a failure probability. Therefore, it is fictitious that the use of an adequate safety factor value implies the absence of failure risk. Thus, a reliability analysis, applied to a real building with an access ramp whose foundations are composed of precast concrete piles, based on the probabilistic moments, mean, and coefficient of variation, associated with the variability of pile resistance and solicitation, is presented in this article. The values obtained for the safety factors (2.14 and 1.98 for the building and the ramp foundations, respectively) and failure probabilities (1:2,244 and 1:3,131 for the building and the ramp foundations, respectively) implies that the project in question has an acceptable safety level. This article allows us to conclude that a small variation in the reliability index results in a large variation in failure probability; that a greater global safety factor does not necessarily lead to a lower failure probability and it becomes evident that this reliability analysis is a practical way, to manage the uncertainties inherent in foundation design, allowing rational decision making regarding performance.
DOI: 10.6084/m9.figshare.14268444
title: Dehydrobufotenin extracted from the Amazonian toad Rhinella marina (Anura: Bufonidae) as a prototype molecule for the development of antiplasmodial drugs

description: Abstract Background: The resistance against antimalarial drugs represents a global challenge in the fight and control of malaria. The Brazilian biodiversity can be an important tool for research and development of new medicinal products. In this context, toxinology is a multidisciplinary approach on the development of new drugs, including the isolation, purification, and evaluation of the pharmacological activities of natural toxins. The present study aimed to evaluate the cytotoxicity, as well as the antimalarial activity in silico and in vitro of four compounds isolated from Rhinella marina venom as potential oral drug prototypes. Methods: Four compounds were challenged against 35 target proteins from P. falciparum and screened to evaluate their physicochemical properties using docking assay in Brazilian Malaria Molecular Targets (BraMMT) software and in silico assay in OCTOPUS® software. The in vitro antimalarial activity of the compounds against the 3D7 Plasmodium falciparum clones were assessed using the SYBR Green I based assay (IC50). For the cytotoxic tests, the LD50 was determined in human pulmonary fibroblast cell line using the [3(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] (MTT) assay. Results: All compounds presented a ligand-receptor interaction with ten Plasmodium falciparum-related protein targets, as well as antimalarial activity against chloroquine resistant strain (IC50 = 3.44 μM to 19.11 μM). Three of them (dehydrobufotenine, marinobufagin, and bufalin) showed adequate conditions for oral drug prototypes, with satisfactory prediction of absorption, permeability, and absence of toxicity. In the cell viability assay, only dehydrobufotenin was selective for the parasite. Conclusions: Dehydrobufotenin revealed to be a potential oral drug prototype presenting adequate antimalarial activity and absence of cytotoxicity, therefore should be subjected to further studies.
DOI: 10.6084/m9.figshare.14268449
title: Hematite and quartz microflotation using millet starch as depressant

description: Abstract Brazil is among the world's largest iron ore producers. The standard concentration method is reverse cationic flotation using amines, and their derivatives, such as quartz collector and corn (as either grits, flour, or starch) as the hematite depressant. Corn is considered cheap, abundant, and available all around the country. However, its demand has been abruptly increasing over the last few years, mainly due to the emerging of new attractive markets, such as ethanol production. In order to propose a feasible replacement for corn, hematite and quartz samples from the Brazilian Iron Quadrangle were tested in a modified Hallimond tube using millet starch as depressant for the first time (corn and sorghum starch were used as benchmark). Tests were carried out with four different depressant dosages and four different pHs, all in triplicate. It was possible to reach quartz floatability above 98% and hematite depressability above 93% for millet and sorghum starches. This fundamental study shows that replacing corn with millet poses a real opportunity to reduce operational costs.
DOI: 10.6084/m9.figshare.14268444.v1
title: Dehydrobufotenin extracted from the Amazonian toad Rhinella marina (Anura: Bufonidae) as a prototype molecule for the development of antiplasmodial drugs

description: Abstract Background: The resistance against antimalarial drugs represents a global challenge in the fight and control of malaria. The Brazilian biodiversity can be an important tool for research and development of new medicinal products. In this context, toxinology is a multidisciplinary approach on the development of new drugs, including the isolation, purification, and evaluation of the pharmacological activities of natural toxins. The present study aimed to evaluate the cytotoxicity, as well as the antimalarial activity in silico and in vitro of four compounds isolated from Rhinella marina venom as potential oral drug prototypes. Methods: Four compounds were challenged against 35 target proteins from P. falciparum and screened to evaluate their physicochemical properties using docking assay in Brazilian Malaria Molecular Targets (BraMMT) software and in silico assay in OCTOPUS® software. The in vitro antimalarial activity of the compounds against the 3D7 Plasmodium falciparum clones were assessed using the SYBR Green I based assay (IC50). For the cytotoxic tests, the LD50 was determined in human pulmonary fibroblast cell line using the [3(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] (MTT) assay. Results: All compounds presented a ligand-receptor interaction with ten Plasmodium falciparum-related protein targets, as well as antimalarial activity against chloroquine resistant strain (IC50 = 3.44 μM to 19.11 μM). Three of them (dehydrobufotenine, marinobufagin, and bufalin) showed adequate conditions for oral drug prototypes, with satisfactory prediction of absorption, permeability, and absence of toxicity. In the cell viability assay, only dehydrobufotenin was selective for the parasite. Conclusions: Dehydrobufotenin revealed to be a potential oral drug prototype presenting adequate antimalarial activity and absence of cytotoxicity, therefore should be subjected to further studies.
DOI: 10.6084/m9.figshare.14268449.v1
title: Hematite and quartz microflotation using millet starch as depressant

description: Abstract Brazil is among the world's largest iron ore producers. The standard concentration method is reverse cationic flotation using amines, and their derivatives, such as quartz collector and corn (as either grits, flour, or starch) as the hematite depressant. Corn is considered cheap, abundant, and available all around the country. However, its demand has been abruptly increasing over the last few years, mainly due to the emerging of new attractive markets, such as ethanol production. In order to propose a feasible replacement for corn, hematite and quartz samples from the Brazilian Iron Quadrangle were tested in a modified Hallimond tube using millet starch as depressant for the first time (corn and sorghum starch were used as benchmark). Tests were carried out with four different depressant dosages and four different pHs, all in triplicate. It was possible to reach quartz floatability above 98% and hematite depressability above 93% for millet and sorghum starches. This fundamental study shows that replacing corn with millet poses a real opportunity to reduce operational costs.
DOI: 10.6084/m9.figshare.14268464
title: In-between motivations and effects. Residential mobility in contemporary Argentina

description: Abstract This research study explores the tensions that “residential movements” coming from big cities generate on small and medium-sized cities in contemporary Argentina. In the light of two ethnographic cases, the study presents a bi-dimensional model to retrieve the motivations of metropolitan flows and to take into account the effects that mobility produces on specific territories, sociability patterns, temporal perceptions and identity processes. Moreover, through this study we challenge some of the concepts most deeply rooted in the history of the social sciences.
DOI: 10.6084/m9.figshare.14268464.v1
title: In-between motivations and effects. Residential mobility in contemporary Argentina

description: Abstract This research study explores the tensions that “residential movements” coming from big cities generate on small and medium-sized cities in contemporary Argentina. In the light of two ethnographic cases, the study presents a bi-dimensional model to retrieve the motivations of metropolitan flows and to take into account the effects that mobility produces on specific territories, sociability patterns, temporal perceptions and identity processes. Moreover, through this study we challenge some of the concepts most deeply rooted in the history of the social sciences.
DOI: 10.6084/m9.figshare.14268479
title: Renovation, urban extractivism and environmental conflict in the northern riverside area of Buenos Aires

description: Abstract This article analyzes a case of urban renewal in the city of Buenos Aires that has been led by the public sector and the real estate sector within an urban entrepreneurial regime since 2004. It also studies the social mobilization that arose in opposition to it, as environmental issues became central to the conflict. For those involved in forging a new model of urban development, nature entails an opportunity to generate surplus value. Meanwhile, other collective actors dispute the installation of these urban developments, pointing out their environmental impact and decrying the imposition of a commercial logic in their territory. Based on an ethnographic approach, this article aims to contribute to a larger debate on urban extractivism and people’s right to access green and public spaces, which are becoming more and more scarce.
DOI: 10.6084/m9.figshare.14268479.v1
title: Renovation, urban extractivism and environmental conflict in the northern riverside area of Buenos Aires

description: Abstract This article analyzes a case of urban renewal in the city of Buenos Aires that has been led by the public sector and the real estate sector within an urban entrepreneurial regime since 2004. It also studies the social mobilization that arose in opposition to it, as environmental issues became central to the conflict. For those involved in forging a new model of urban development, nature entails an opportunity to generate surplus value. Meanwhile, other collective actors dispute the installation of these urban developments, pointing out their environmental impact and decrying the imposition of a commercial logic in their territory. Based on an ethnographic approach, this article aims to contribute to a larger debate on urban extractivism and people’s right to access green and public spaces, which are becoming more and more scarce.
DOI: 10.6084/m9.figshare.14268491
title: Study of Microstructure and Corrosion Behavior of Multilayered Ni Coatings by Ultrasound-assisted Electrodeposition

description: Abstract Multilayered Ni coatings were successfully deposited on martensitic stainless-steel substrates by electrodeposition method with intermittent ultrasound. It is a novel kind of multilayered microstructure of stacked-up sandwiches, whose compositions of each monolayer are the same to those of its adjacent layers. The grains of ordinary Ni layers are columnar, vertically to the substrate surface, but the grains of ultrasonic Ni layers grow parallel along the substrate surface. By multilayered structure, the pinholes running through the coating were obviously inhibited, because the multilayered Ni coating can cover the whole surface of the substrate without the direct pinhole passages down to the substrate. Therefore, its corrosion mechanism is the uniform corrosion. For the ordinary Ni coating, the direct corrosion on the substrate can occur through the pinholes, which are the convenient passages for corrosive media to reach the substrate easily. This behavior can lead to the Fe/Ni galvanic corrosion, coating adhesion reduction, and quick formation of coating cracks in the ordinary Ni coating.
DOI: 10.6084/m9.figshare.14268491.v1
title: Study of Microstructure and Corrosion Behavior of Multilayered Ni Coatings by Ultrasound-assisted Electrodeposition

description: Abstract Multilayered Ni coatings were successfully deposited on martensitic stainless-steel substrates by electrodeposition method with intermittent ultrasound. It is a novel kind of multilayered microstructure of stacked-up sandwiches, whose compositions of each monolayer are the same to those of its adjacent layers. The grains of ordinary Ni layers are columnar, vertically to the substrate surface, but the grains of ultrasonic Ni layers grow parallel along the substrate surface. By multilayered structure, the pinholes running through the coating were obviously inhibited, because the multilayered Ni coating can cover the whole surface of the substrate without the direct pinhole passages down to the substrate. Therefore, its corrosion mechanism is the uniform corrosion. For the ordinary Ni coating, the direct corrosion on the substrate can occur through the pinholes, which are the convenient passages for corrosive media to reach the substrate easily. This behavior can lead to the Fe/Ni galvanic corrosion, coating adhesion reduction, and quick formation of coating cracks in the ordinary Ni coating.
DOI: 10.6084/m9.figshare.14268513
title: Interaction of Pb, Ni and Cd with Aquatic Humic Substances of Amazonian Blackwater Rivers

description: In this study, the extraction and characterization of aquatic humic substances (AHS) from two blackwater rivers in the Amazon basin was carried out in order to assess the seasonal effects in the AHS structure. In addition, an investigation of the complexing capacities (CC) of the structures containing the metal ions CdII, NiII and PbII was also done. The characterization (of the AHS) was done using UV-Vis, molecular fluorescence, and infrared spectroscopy. AHS from the Negro River showed more aromatic characteristics in its structures and molecular weight, than the AHS from the Carú River. The AHS studied presented a seasonal pattern characterized by higher humification levels during the rainy season. For all the metals, the AHS complexing capacity was higher for the Negro River. The highest complexing capacities were observed for the NiII assays, which were 0.56 and 0.12 µmol NiII mg-1 dissolved organic carbon (DOC), for AHS RN and AHS RC-II, respectively. We concluded that the transport, bioavailability, and toxicity, of these metal species should be higher for Carú River.
DOI: 10.6084/m9.figshare.14268507
title: Characterization, Source Apportionment and Health Risk Assessment of PM2.5 for a Rural Classroom in the Amazon: A Case Study

description: Classrooms are microenvironments in which children and teenagers may be exposed to fine particulate matter (PM2.5). Iranduba is a rural city in the Amazon region close to many brick kilns and road with high traffic levels. In this study, indoor and outdoor PM2.5 levels were measured in a classroom in Iranduba, and the PM2.5 exposure effects on student’s health were calculated. High indoor PM2.5 concentrations and high indoor-to-outdoor ratio values indicated particle accumulation within the classroom. The high percentage of black carbon (10%) in the dry season revealed the influence of burning processes on PM2.5 composition. Se, S, and Pb had an enrichment factor &gt; 5, indicating that there is an important source for these elements in the city. The positive matrix factorization (PMF) model indicated soil resuspension, burning processes and vehicular emissions as the main PM2.5 sources. The excess risk shows that our classroom occupants are expected to be 30% more likely to develop lung-cancer than a group exposed to a background level of PM2.5. Therefore, it is important to have an effective ventilation system in order to reduce the accumulation of pollutants within the classroom and also to control/decrease the emission of pollutants in the city.
DOI: 10.6084/m9.figshare.14268512.v1
title: Door-to-balloon Time in Cardiovascular Emergency Care in a Hospital of Northern Brazil

description: Abstract Background The use of an adequate door-to-balloon time (≤ 90 minutes) is crucial in improving the quality of care provided to patients with ST-segment elevation myocardial infarction (STEMI). Objective To determine the door-to-balloon time in the management of STEMI patients in a cardiovascular emergency department in a hospital of northern Brazil. Methods This was a cross-sectional study based on review of medical records. A total of 109 patients with STEMI admitted to the emergency department of a referral cardiology hospital in Pará State, Brazil, between May 2017 and December 2017. Correlations of the door-to-balloon time with length of hospital stay and mortality rate were assessed, as well as whether the time components of the door-to-balloon time affected the delay in performing primary percutaneous coronary intervention. Quantitative variables were analyzed by Spearman correlation and the G test was used for categorical variables. A p&lt;0.05 was set as statistically significant. Results Median door-to-balloon time was 104 minutes. No significant correlation was found between door-to-balloon time and length of hospital stay or deaths, but significant correlations were found between door-to-balloon time and door-to-ECG time (p&lt;0.001) and ECG-to-activation (of an interventional cardiologist) time (p&lt;0.001). Conclusion The door-to-balloon time was longer the recommended and was not correlated with the length of hospital stay or in-hospital mortality. Door-to-ECG time and ECG-to-activation time contributed to the delay in performing the primary percutaneous coronary intervention. Int J Cardiovasc Sci. 2020; [online].ahead print, PP.0-0
DOI: 10.6084/m9.figshare.14268507.v1
title: Characterization, Source Apportionment and Health Risk Assessment of PM2.5 for a Rural Classroom in the Amazon: A Case Study

description: Classrooms are microenvironments in which children and teenagers may be exposed to fine particulate matter (PM2.5). Iranduba is a rural city in the Amazon region close to many brick kilns and road with high traffic levels. In this study, indoor and outdoor PM2.5 levels were measured in a classroom in Iranduba, and the PM2.5 exposure effects on student’s health were calculated. High indoor PM2.5 concentrations and high indoor-to-outdoor ratio values indicated particle accumulation within the classroom. The high percentage of black carbon (10%) in the dry season revealed the influence of burning processes on PM2.5 composition. Se, S, and Pb had an enrichment factor &gt; 5, indicating that there is an important source for these elements in the city. The positive matrix factorization (PMF) model indicated soil resuspension, burning processes and vehicular emissions as the main PM2.5 sources. The excess risk shows that our classroom occupants are expected to be 30% more likely to develop lung-cancer than a group exposed to a background level of PM2.5. Therefore, it is important to have an effective ventilation system in order to reduce the accumulation of pollutants within the classroom and also to control/decrease the emission of pollutants in the city.
DOI: 10.6084/m9.figshare.14268516
title: Developmental surveillance in primary health care: absence of child development milestones and associated factors

description: Abstract Objectives: to identify the absence of one or more general child development milestones and by domains, and associated factors. Methods: cross-sectional study with 334 children under three years of age conducted out at Primary Health Care Facilities, São Paulo, Brazil. The dependent variable was the general child development and the fine motor, gross motor, social and psychic domains evaluated using the Developmental Surveillance Instrument of the Brazilian Ministry of Health. Data were obtained by interviewing the mothers and observing children. The chi-square test and logistic regression analyses were used. Results: absence of one or more milestones of general child development was found in 52.1% of children, especially, in the fine motor domain. We found an association between general child development with age (OR = 4.4; CI95%= 2.0-9.9) and the place of stay of the child who does not attend daycare (OR = 3.7; CI95%= 1.3-10.5). Conclusions: the absence of one or more milestones of general child development is high and associated with aspects of the child and the environment. This emphasizes the importance of promoting developmental surveillance in Primary Health Care Facilities among health professionals using the official instrument recommended by the Brazilian Ministry of Health.
DOI: 10.6084/m9.figshare.14268512
title: Door-to-balloon Time in Cardiovascular Emergency Care in a Hospital of Northern Brazil

description: Abstract Background The use of an adequate door-to-balloon time (≤ 90 minutes) is crucial in improving the quality of care provided to patients with ST-segment elevation myocardial infarction (STEMI). Objective To determine the door-to-balloon time in the management of STEMI patients in a cardiovascular emergency department in a hospital of northern Brazil. Methods This was a cross-sectional study based on review of medical records. A total of 109 patients with STEMI admitted to the emergency department of a referral cardiology hospital in Pará State, Brazil, between May 2017 and December 2017. Correlations of the door-to-balloon time with length of hospital stay and mortality rate were assessed, as well as whether the time components of the door-to-balloon time affected the delay in performing primary percutaneous coronary intervention. Quantitative variables were analyzed by Spearman correlation and the G test was used for categorical variables. A p&lt;0.05 was set as statistically significant. Results Median door-to-balloon time was 104 minutes. No significant correlation was found between door-to-balloon time and length of hospital stay or deaths, but significant correlations were found between door-to-balloon time and door-to-ECG time (p&lt;0.001) and ECG-to-activation (of an interventional cardiologist) time (p&lt;0.001). Conclusion The door-to-balloon time was longer the recommended and was not correlated with the length of hospital stay or in-hospital mortality. Door-to-ECG time and ECG-to-activation time contributed to the delay in performing the primary percutaneous coronary intervention. Int J Cardiovasc Sci. 2020; [online].ahead print, PP.0-0
DOI: 10.26188/14268503
title: Scopus CCT publications

description: List of publications from Amit Lampit's CCT research program. Exported from Scopus 23/3/2021