cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.7352105.v1
title: Supplementary Material for: Weighted Gene Correlation Network Analysis (WGCNA) Detected Loss of MAGI2 Promotes Chronic Kidney Disease (CKD) by Podocyte Damage

description: <b><i>Background/Aims:</i></b> Podocyte damage is associated with proteinuria, glomerulosclerosis and decline of renal function. This study aimed to screen critical genes associated with podocyte injury in chronic kidney disease (CKD) by weighted gene correlation network analysis (WGCNA), and explore related functions. <b><i>Methods:</i></b> GSE66107, GSE93798, GSE30528, GSE32591 gene expression data including podocyte injury models or glomeruli in CKD patients were downloaded from the GEO database. R was used for data analysis. Differentially expressed genes (DEGs) (FDR&lt; 0.05 or |Fold Change|≥1.5) in GSE993395 were assessed by WGCNA. According to Gene Ontology (GO) and known podocyte standard genes (PSGs), podocyte injury-associated modules were defined, with hub genes selected based on average intramodular connectivity. The Cytoscape software was used for network visualization. Nephroseq was used to assess the clinical significance of hub genes. Small interfering RNA (siRNA) was used to evaluate the roles of hub genes in podocyte injury <b><i>Results:</i></b> Totally 7957 DEGs were screened, with 15 (co.DEGs) altered in all 4 datasets; 4031 DEGs were used for WGCNA, encompassing 12 modules. Green modules (most PSGs and co.DEGs) were significantly enriched in glomerular development, and considered podocyte injury-associated modules. Furthermore, MAGI2 (a hub gene) was also a co.DEG and PSG. Glomerular MAGI2 levels were reduced in various kidney diseases, and positively and negatively associated with glomerular filtration rate and urinary protein levels in CKD patients. Moreover, MAIG2 knockdown reduced NPHS2, CD2AP and SYNPO levels, and induced podocyte rearrangement and apoptosis. <b><i>Conclusion:</i></b> MAGI2 identified by WGCNA regulates cytoskeletal rearrangement in podocytes, with its loss predisposing to proteinuria and CKD.
DOI: 10.7284/124538
title: Barometer data collected during research cruise PE16-26 using a Vaisala PTB101B instrument system onboard the platform RV Pelican

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7352036
title: Appendix Table06

description: This table relates the amphora samples with one of the fabric groups
DOI: 10.7284/124602
title: CTD (Conductivity, Temperature, Depth) data collected during research cruise PE16-26 using a Sea-Bird SBE-911+ instrument system onboard the platform RV Pelican

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7352033
title: Valley network morphology in the greater Meridiani Planum region, Mars

description: The Greater Meridiani Planum region on Mars is a key locale for a diverse range of fluvial landforms. Valley networks in this region have a range of geomorphologic styles that include negative relief, positive relief, or some combination of both along their lengths. Using high-resolution ∼5–6 m/pixel orbital images in ArcGIS Desktop software, we mapped previously under-recognized fine-scale valley networks within the Greater Meridiani Planum region and recorded their geomorphic characteristics as feature attributes. The objectives in using the mapped features are to 1) document the full range of valley network morphologic types in the region, 2) document changes in morphologic types both on a regional scale and along the valley network segments, and 3) to use the mapped features along with other geologic information from previous studies to better understand landscape evolution in the Greater Meridiani Planum region.
DOI: 10.7284/124579
title: GNSS (Global Navigation Satellite System) data collected during research cruise PE16-26 using a Ashtech ADU800 instrument system onboard the platform RV Pelican

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7352033.v1
title: Valley network morphology in the greater Meridiani Planum region, Mars

description: The Greater Meridiani Planum region on Mars is a key locale for a diverse range of fluvial landforms. Valley networks in this region have a range of geomorphologic styles that include negative relief, positive relief, or some combination of both along their lengths. Using high-resolution ∼5–6 m/pixel orbital images in ArcGIS Desktop software, we mapped previously under-recognized fine-scale valley networks within the Greater Meridiani Planum region and recorded their geomorphic characteristics as feature attributes. The objectives in using the mapped features are to 1) document the full range of valley network morphologic types in the region, 2) document changes in morphologic types both on a regional scale and along the valley network segments, and 3) to use the mapped features along with other geologic information from previous studies to better understand landscape evolution in the Greater Meridiani Planum region.
DOI: 10.7284/124539
title: Hygrometer data collected during research cruise PE16-26 using a Vaisala HMP45 instrument system onboard the platform RV Pelican

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7352033.v2
title: Valley network morphology in the greater Meridiani Planum region, Mars

description: The Greater Meridiani Planum region on Mars is a key locale for a diverse range of fluvial landforms. Valley networks in this region have a range of geomorphologic styles that include negative relief, positive relief, or some combination of both along their lengths. Using high-resolution ∼5–6 m/pixel orbital images in ArcGIS Desktop software, we mapped previously under-recognized fine-scale valley networks within the Greater Meridiani Planum region and recorded their geomorphic characteristics as feature attributes. The objectives in using the mapped features are to 1) document the full range of valley network morphologic types in the region, 2) document changes in morphologic types both on a regional scale and along the valley network segments, and 3) to use the mapped features along with other geologic information from previous studies to better understand landscape evolution in the Greater Meridiani Planum region.
DOI: 10.6084/m9.figshare.7352000
title: Proteomic analysis

description: Compare the proteomic profiling of ES-2 and OVCA433 cells in OCM vs DMEM control.
DOI: 10.7284/124540
title: Transmissometer data collected during research cruise PE16-26 using a WET Labs C-Star instrument system onboard the platform RV Pelican

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7352033.v3
title: Valley network morphology in the greater Meridiani Planum region, Mars

description: The Greater Meridiani Planum region on Mars is a key locale for a diverse range of fluvial landforms. Valley networks in this region have a range of geomorphologic styles that include negative relief, positive relief, or some combination of both along their lengths. Using high-resolution ∼5–6 m/pixel orbital images in ArcGIS Desktop software, we mapped previously under-recognized fine-scale valley networks within the Greater Meridiani Planum region and recorded their geomorphic characteristics as feature attributes. The objectives in using the mapped features are to 1) document the full range of valley network morphologic types in the region, 2) document changes in morphologic types both on a regional scale and along the valley network segments, and 3) to use the mapped features along with other geologic information from previous studies to better understand landscape evolution in the Greater Meridiani Planum region.
DOI: 10.7284/124541
title: TSG (Thermosalinograph) data collected during research cruise PE16-26 using a Sea-Bird SBE-21 instrument system onboard the platform RV Pelican

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7351994
title: Lipidomic analysis

description: Lipidomic analysis
DOI: 10.6084/m9.figshare.7352033.v4
title: Valley network morphology in the greater Meridiani Planum region, Mars

description: The Greater Meridiani Planum region on Mars is a key locale for a diverse range of fluvial landforms. Valley networks in this region have a range of geomorphologic styles that include negative relief, positive relief, or some combination of both along their lengths. Using high-resolution ∼5–6 m/pixel orbital images in ArcGIS Desktop software, we mapped previously under-recognized fine-scale valley networks within the Greater Meridiani Planum region and recorded their geomorphic characteristics as feature attributes. The objectives in using the mapped features are to 1) document the full range of valley network morphologic types in the region, 2) document changes in morphologic types both on a regional scale and along the valley network segments, and 3) to use the mapped features along with other geologic information from previous studies to better understand landscape evolution in the Greater Meridiani Planum region.
DOI: 10.7284/124580
title: GNSS (Global Navigation Satellite System) data collected during research cruise PE17-01 using a Ashtech ADU800 instrument system onboard the platform RV Pelican

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7352033.v5
title: Valley network morphology in the greater Meridiani Planum region, Mars

description: The Greater Meridiani Planum region on Mars is a key locale for a diverse range of fluvial landforms. Valley networks in this region have a range of geomorphologic styles that include negative relief, positive relief, or some combination of both along their lengths. Using high-resolution ∼5–6 m/pixel orbital images in ArcGIS Desktop software, we mapped previously under-recognized fine-scale valley networks within the Greater Meridiani Planum region and recorded their geomorphic characteristics as feature attributes. The objectives in using the mapped features are to 1) document the full range of valley network morphologic types in the region, 2) document changes in morphologic types both on a regional scale and along the valley network segments, and 3) to use the mapped features along with other geologic information from previous studies to better understand landscape evolution in the Greater Meridiani Planum region.
DOI: 10.6084/m9.figshare.7352033.v6
title: Valley network morphology in the greater Meridiani Planum region, Mars

description: The Greater Meridiani Planum region on Mars is a key locale for a diverse range of fluvial landforms. Valley networks in this region have a range of geomorphologic styles that include negative relief, positive relief, or some combination of both along their lengths. Using high-resolution ∼5–6 m/pixel orbital images in ArcGIS Desktop software, we mapped previously under-recognized fine-scale valley networks within the Greater Meridiani Planum region and recorded their geomorphic characteristics as feature attributes. The objectives in using the mapped features are to 1) document the full range of valley network morphologic types in the region, 2) document changes in morphologic types both on a regional scale and along the valley network segments, and 3) to use the mapped features along with other geologic information from previous studies to better understand landscape evolution in the Greater Meridiani Planum region.
DOI: 10.7284/126353
title: ADCP (Acoustic Doppler Current Profiler) data collected during research cruise PE17-02 using a Hawaii UHDAS instrument system onboard the platform RV Pelican

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7351991
title: Source data

description: Raw data for all graphs with line or bar charts analyzed by GRAPHPAD PRISM software.
DOI: 10.6084/m9.figshare.7351991.v1
title: Source data

description: Raw data for all graphs with line or bar charts analyzed by GRAPHPAD PRISM software.
DOI: 10.7284/124546
title: Barometer data collected during research cruise PE17-02 using a Vaisala PTB101B instrument system onboard the platform RV Pelican

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/124604
title: CTD (Conductivity, Temperature, Depth) data collected during research cruise PE17-02 using a Sea-Bird SBE-911+ instrument system onboard the platform RV Pelican

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7351943
title: Novel nicotinamide skin-adhesive hot melt extrudates for treatment of acne

description: <b>Objectives</b>: Hot melt extrusion is a continuous process with wide industrial applicability. Till current date, there have been no reports on the formulation of extrudates for topical treatment of dermatological diseases. <b>Methods</b>: The aim of the present work was to prepare and characterize medicated hot melt extrudates based on Soluplus polymer and nicotinamide, and to explore their applicability in acne treatment. The extrudates were characterized using DSC, FTIR, XRD, and DVS. The extrudates were also tested for their skin adhesion potential, ability to deposit nicotinamide in different skin layers, and their clinical efficacy in acne patients. <b>Results</b>: The 10% nicotinamide extrudates exhibited amorphous nature which was reserved during storage, with no chemical interaction between nicotinamide and Soluplus. Upon contrasting the skin adhesion and drug deposition of extrudates and nicotinamide gel, it was evident that the extrudates displayed significantly higher adhesion and drug deposition reaching 4.8 folds, 5.3 folds, and 4.3 folds more in the stratum corneum, epidermis and dermis, respectively. Furthermore, the extrudates significantly reduced the total number of acne lesions in patients by 61.3% compared to 42.14% with the nicotinamide gel. <b>Conclusion</b>: Soluplus extrudates are promising topical drug delivery means for the treatment of dermatological diseases.
DOI: 10.6084/m9.figshare.7351943.v1
title: Novel nicotinamide skin-adhesive hot melt extrudates for treatment of acne

description: <b>Objectives</b>: Hot melt extrusion is a continuous process with wide industrial applicability. Till current date, there have been no reports on the formulation of extrudates for topical treatment of dermatological diseases. <b>Methods</b>: The aim of the present work was to prepare and characterize medicated hot melt extrudates based on Soluplus polymer and nicotinamide, and to explore their applicability in acne treatment. The extrudates were characterized using DSC, FTIR, XRD, and DVS. The extrudates were also tested for their skin adhesion potential, ability to deposit nicotinamide in different skin layers, and their clinical efficacy in acne patients. <b>Results</b>: The 10% nicotinamide extrudates exhibited amorphous nature which was reserved during storage, with no chemical interaction between nicotinamide and Soluplus. Upon contrasting the skin adhesion and drug deposition of extrudates and nicotinamide gel, it was evident that the extrudates displayed significantly higher adhesion and drug deposition reaching 4.8 folds, 5.3 folds, and 4.3 folds more in the stratum corneum, epidermis and dermis, respectively. Furthermore, the extrudates significantly reduced the total number of acne lesions in patients by 61.3% compared to 42.14% with the nicotinamide gel. <b>Conclusion</b>: Soluplus extrudates are promising topical drug delivery means for the treatment of dermatological diseases.
DOI: 10.7284/124581
title: GNSS (Global Navigation Satellite System) data collected during research cruise PE17-02 using a Ashtech ADU800 instrument system onboard the platform RV Pelican

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/124547
title: Hygrometer data collected during research cruise PE17-02 using a Vaisala HMP45 instrument system onboard the platform RV Pelican

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/124548
title: Transmissometer data collected during research cruise PE17-02 using a WET Labs C-Star instrument system onboard the platform RV Pelican

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/124549
title: TSG (Thermosalinograph) data collected during research cruise PE17-02 using a Sea-Bird SBE-21 instrument system onboard the platform RV Pelican

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/126354
title: ADCP (Acoustic Doppler Current Profiler) data collected during research cruise PE17-03 using a Hawaii UHDAS instrument system onboard the platform RV Pelican

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/124550
title: Barometer data collected during research cruise PE17-03 using a Vaisala PTB101B instrument system onboard the platform RV Pelican

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7351334
title: MOESM2 of Hate is in the air! But where? Introducing an algorithm to detect hate speech in digital microenvironments

description: Additional file 2. Anonymized data set used for the present study. The anonymized variables are in red.
DOI: 10.7284/124605
title: CTD (Conductivity, Temperature, Depth) data collected during research cruise PE17-03 using a Sea-Bird SBE-911+ instrument system onboard the platform RV Pelican

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7351334.v1
title: MOESM2 of Hate is in the air! But where? Introducing an algorithm to detect hate speech in digital microenvironments

description: Additional file 2. Anonymized data set used for the present study. The anonymized variables are in red.
DOI: 10.7284/124582
title: GNSS (Global Navigation Satellite System) data collected during research cruise PE17-03 using a Ashtech ADU800 instrument system onboard the platform RV Pelican

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/124551
title: Hygrometer data collected during research cruise PE17-03 using a Vaisala HMP45 instrument system onboard the platform RV Pelican

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/124552
title: Transmissometer data collected during research cruise PE17-03 using a WET Labs C-Star instrument system onboard the platform RV Pelican

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7351310
title: Additional file 3: of A preliminary integrated genetic map distinguishes every chromosome pair and locates essential genes related to abiotic adaptation of Crassostrea angulata/gigas

description: Table S3. Summary of Gene Ontology term enrichment statistics. (XLSX 2457 kb)
DOI: 10.6084/m9.figshare.7351310.v1
title: Additional file 3: of A preliminary integrated genetic map distinguishes every chromosome pair and locates essential genes related to abiotic adaptation of Crassostrea angulata/gigas

description: Table S3. Summary of Gene Ontology term enrichment statistics. (XLSX 2457 kb)
DOI: 10.7284/124553
title: TSG (Thermosalinograph) data collected during research cruise PE17-03 using a Sea-Bird SBE-21 instrument system onboard the platform RV Pelican

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7351301
title: Additional file 2: of A preliminary integrated genetic map distinguishes every chromosome pair and locates essential genes related to abiotic adaptation of Crassostrea angulata/gigas

description: Table S2. Data of BAC-contigs annotations. (XLSX 19 kb)
DOI: 10.6084/m9.figshare.7351301.v1
title: Additional file 2: of A preliminary integrated genetic map distinguishes every chromosome pair and locates essential genes related to abiotic adaptation of Crassostrea angulata/gigas

description: Table S2. Data of BAC-contigs annotations. (XLSX 19 kb)
DOI: 10.7284/126355
title: ADCP (Acoustic Doppler Current Profiler) data collected during research cruise PE17-04 using a Hawaii UHDAS instrument system onboard the platform RV Pelican

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/124554
title: Barometer data collected during research cruise PE17-04 using a Vaisala PTB101B instrument system onboard the platform RV Pelican

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/124606
title: CTD (Conductivity, Temperature, Depth) data collected during research cruise PE17-04 using a Sea-Bird SBE-911+ instrument system onboard the platform RV Pelican

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/124583
title: GNSS (Global Navigation Satellite System) data collected during research cruise PE17-04 using a Ashtech ADU800 instrument system onboard the platform RV Pelican

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7351274
title: Additional file 5: of Computational analysis reveals histotype-dependent molecular profile and actionable mutation effects across cancers

description: Cell lines analysis results. Two tables containing results on cell line data analysis. (XLSX 14 kb)
DOI: 10.7284/124555
title: Hygrometer data collected during research cruise PE17-04 using a Vaisala HMP45 instrument system onboard the platform RV Pelican

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7351274.v1
title: Additional file 5: of Computational analysis reveals histotype-dependent molecular profile and actionable mutation effects across cancers

description: Cell lines analysis results. Two tables containing results on cell line data analysis. (XLSX 14 kb)
DOI: 10.7284/124556
title: Transmissometer data collected during research cruise PE17-04 using a WET Labs C-Star instrument system onboard the platform RV Pelican

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7351265
title: Additional file 4: of Computational analysis reveals histotype-dependent molecular profile and actionable mutation effects across cancers

description: Actionable genes. A table with details on all actionable genes analyzed. (XLSX 14 kb)
DOI: 10.7284/124557
title: TSG (Thermosalinograph) data collected during research cruise PE17-04 using a Sea-Bird SBE-21 instrument system onboard the platform RV Pelican

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7351265.v1
title: Additional file 4: of Computational analysis reveals histotype-dependent molecular profile and actionable mutation effects across cancers

description: Actionable genes. A table with details on all actionable genes analyzed. (XLSX 14 kb)
DOI: 10.6084/m9.figshare.7351256
title: Additional file 3: of Computational analysis reveals histotype-dependent molecular profile and actionable mutation effects across cancers

description: Complete listing of results. Detailed listing of the results of discriminability and cross cancer effect analysis. (CSV 210 kb)
DOI: 10.7284/124584
title: GNSS (Global Navigation Satellite System) data collected during research cruise PE17-05A using a Ashtech ADU800 instrument system onboard the platform RV Pelican

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7351256.v1
title: Additional file 3: of Computational analysis reveals histotype-dependent molecular profile and actionable mutation effects across cancers

description: Complete listing of results. Detailed listing of the results of discriminability and cross cancer effect analysis. (CSV 210 kb)
DOI: 10.7284/124585
title: GNSS (Global Navigation Satellite System) data collected during research cruise PE17-05B using a Ashtech ADU800 instrument system onboard the platform RV Pelican

description: Original (unprocessed) data collected during a Field_expedition