cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.4994429
title: App for extracting texture features from digital raw CC view mammograms

description: This is the app for a paper initially presented in the 8th International Breast Density and Cancer Risk Assessment Workshop and published in Breast Cancer Research (Wang et al., 2017). It extracts useful mammographic texture features that are predictive of cancer risk.<br>For the composite risk score, please refer to the paper; alternatively one can recover the score (in the original scale as used in the paper) using the following formula: risk score = -20.93 + 184.12*SumAverage16 + 82.83*SumAverage32 + 85.74*SumAverage64.<br><br>Requires MATLAB Runtime 9.1 (http://www.mathworks.com/products/compiler/mcr/index.html)! If you are not sure what to do, download the installer (MyAppInstaller_web.exe) and install. The app is also packed in a ZIP file which contains the executable file (mmtext.exe) without installation as well as a MATLAB app package.<br>Please cite the paper if you are using this app:Wang, C., Brentnall, A. R., Cuzick, J., Harkness, E. F., Evans, D. G., & Astley, S. (2017). A novel and fully automated mammographic texture analysis for risk prediction: results from two case-control studies. Breast Cancer Res, 19(1), 114. https://doi.org/10.1186/s13058-017-0906-6.
DOI: 10.6084/m9.figshare.4994537.v3
title: Framester

description: Framester is a frame-oriented knowledge graph serving as a hub for many linguistic and factual resources including FrameNet, WordNet, VerbNet, BabelNet, DBpedia, Yago, DOLCE-Zero. Framester creates a highly connected knowledge graph based on a formalisation of Fillmore's frame semantics, hence enabling full-fledged OWL querying and reasoning.
DOI: 10.6084/m9.figshare.4994468.v1
title: Physiological and self-reported disgust reactions to obesity

description: There is accumulating evidence that disgust plays an important role in prejudice toward individuals with obesity, but that research is primarily based on self-reported emotions. In four studies, we examined whether participants displayed a physiological marker of disgust (i.e. levator labii activity recorded using facial electromyography) in response to images of obese individuals, and whether these responses corresponded with their self-reported disgust to those images. All four studies showed the predicted self-reported disgust response toward images of obese individuals. Study 1 further showed that participants exhibited more levator activity to images of obese individuals than to neutral images. However, Studies 2–4 failed to provide any evidence that the targets’ body size affected levator responses. These findings suggest that disgust may operate at multiple levels, and that the disgust response to images of obese individuals may be more of a cognitive-conceptual one than a physiological one.
DOI: 10.6084/m9.figshare.4994537.v4
title: Framester

description: Framester is a frame-oriented knowledge graph serving as a hub for many linguistic and factual resources including FrameNet, WordNet, VerbNet, BabelNet, DBpedia, Yago, DOLCE-Zero. Framester creates a highly connected knowledge graph based on a formalisation of Fillmore's frame semantics, hence enabling full-fledged OWL querying and reasoning.
DOI: 10.6084/m9.figshare.4994537.v5
title: Framester

description: Framester is a frame-oriented knowledge graph serving as a hub for many linguistic and factual resources including FrameNet, WordNet, VerbNet, BabelNet, DBpedia, Yago, DOLCE-Zero. Framester creates a highly connected knowledge graph based on a formalisation of Fillmore's frame semantics, hence enabling full-fledged OWL querying and reasoning.
DOI: 10.6084/m9.figshare.4994243
title: Friedman test results - Blood and XD

description: Friedman test results - Blood and XD
DOI: 10.6084/m9.figshare.4994246
title: Friedman test results - XD

description: Friedman test results - XD
DOI: 10.6084/m9.figshare.4994243.v1
title: Friedman test results - Blood and XD

description: Friedman test results - Blood and XD
DOI: 10.6084/m9.figshare.4994237
title: Friedman test - Blood and XD

description: Friedman test - Blood and XD
DOI: 10.6084/m9.figshare.4994240
title: Friedman test - XD

description: Friedman test - XD
DOI: 10.6084/m9.figshare.4994246.v1
title: Friedman test results - XD

description: Friedman test results - XD
DOI: 10.6084/m9.figshare.4994231
title: DTU frequency

description: Amount of times each DTU was detected in both single and mixed infections.
DOI: 10.6084/m9.figshare.4994237.v1
title: Friedman test - Blood and XD

description: Friedman test - Blood and XD
DOI: 10.6084/m9.figshare.4994231.v2
title: DTU frequency

description: Amount of times each DTU was detected in both single and mixed infections.
DOI: 10.6084/m9.figshare.4994231.v1
title: Tablle II

description: Table II. Amount of times each DTU was detected in both single and mixed infections.
DOI: 10.21421/d2/s0i8pl
title: Data evaluation on early long duration pigeonpea for international varietal trial in 2016-2017

description: Testing materials for highland agro ecological zone of ESA which is adaptable to cold weather
DOI: 10.6084/m9.figshare.4993931
title: Pre-trained models for RECOD "Titans" Participation at ISIC Challenge 2017

description: Pre-trained models for RECOD "Titans" Participation at ISIC Challenge 2017
DOI: 10.6084/m9.figshare.4993901
title: Lifestyle Students DATA

description: Lifestyle Data. Universidad Simón Bolívar, Barranquilla-Colombia
DOI: 10.6084/m9.figshare.4993931.v2
title: Pre-trained models for RECOD "Titans" Participation at ISIC Challenge 2017

description: Pre-trained models for RECOD "Titans" Participation at ISIC Challenge 2017
DOI: 10.6084/m9.figshare.4993895
title: Datasets(Politicsuk,Olympics,Karate,Dolphins,Football,Polbooks,Polblogs)

description: Datasets used in paper "An Efficient Semi-supervised Community Detection Framework in Social Networks"
DOI: 10.6084/m9.figshare.4993901.v1
title: Lifestyle Students DATA

description: Lifestyle Data. Universidad Simón Bolívar, Barranquilla-Colombia
DOI: 10.6084/m9.figshare.4993931.v1
title: Deep Learning Model RC.25

description: Weights for Tensorflow/slim component model used in ISIC 2017 Challenge
DOI: 10.6084/m9.figshare.4993874
title: Diversity of the TLR4 Immunity Receptor in Czech Native Cattle Breeds Revealed Using the Pacific Biosciences Sequencing Platform

description: The allelic variants of immunity genes in historical breeds likely reflect local infection pressure and therefore represent a reservoir for breeding. Screening to determine the diversity of the Toll-like receptor gene <i>TLR4</i> was conducted in two conserved cattle breeds: Czech Red and Czech Red Pied. High-throughput sequencing of pooled PCR amplicons using the PacBio platform revealed polymorphisms, which were subsequently confirmed via genotyping techniques. Eight SNPs found in coding and adjacent regions were grouped into 18 haplotypes, representing a significant portion of the known diversity in the global breed panel and presumably exceeding diversity in production populations. Notably, the ancient Czech Red breed appeared to possess greater haplotype diversity than the Czech Red Pied breed, a Simmental variant, although the haplotype frequencies might have been distorted by significant crossbreeding and bottlenecks in the history of Czech Red cattle. The differences in haplotype frequencies validated the phenotypic distinctness of the local breeds. Due to the availability of Czech Red Pied production herds, the effect of intensive breeding on <i>TLR</i> diversity can be evaluated in this model. The advantages of the Pacific Biosciences technology for the resequencing of long PCR fragments with subsequent direct phasing were independently validated.
DOI: 10.6084/m9.figshare.4993874.v1
title: Diversity of the TLR4 Immunity Receptor in Czech Native Cattle Breeds Revealed Using the Pacific Biosciences Sequencing Platform

description: The allelic variants of immunity genes in historical breeds likely reflect local infection pressure and therefore represent a reservoir for breeding. Screening to determine the diversity of the Toll-like receptor gene <i>TLR4</i> was conducted in two conserved cattle breeds: Czech Red and Czech Red Pied. High-throughput sequencing of pooled PCR amplicons using the PacBio platform revealed polymorphisms, which were subsequently confirmed via genotyping techniques. Eight SNPs found in coding and adjacent regions were grouped into 18 haplotypes, representing a significant portion of the known diversity in the global breed panel and presumably exceeding diversity in production populations. Notably, the ancient Czech Red breed appeared to possess greater haplotype diversity than the Czech Red Pied breed, a Simmental variant, although the haplotype frequencies might have been distorted by significant crossbreeding and bottlenecks in the history of Czech Red cattle. The differences in haplotype frequencies validated the phenotypic distinctness of the local breeds. Due to the availability of Czech Red Pied production herds, the effect of intensive breeding on <i>TLR</i> diversity can be evaluated in this model. The advantages of the Pacific Biosciences technology for the resequencing of long PCR fragments with subsequent direct phasing were independently validated.
DOI: 10.6084/m9.figshare.4993868
title: Preclinical evaluation of the imipridone family, analogs of clinical stage anti-cancer small molecule ONC201, reveals potent anti-cancer effects of ONC212

description: Anti-cancer small molecule ONC201 upregulates the integrated stress response (ISR) and acts as a dual inactivator of Akt/ERK, leading to TRAIL gene activation. ONC201 is under investigation in multiple clinical trials to treat patients with cancer. Given the unique imipridone core chemical structure of ONC201, we synthesized a series of analogs to identify additional compounds with distinct therapeutic properties. Several imipridones with a broad range of <i>in vitro</i> potencies were identified in an exploration of chemical derivatives. Based on <i>in vitro</i> potency in human cancer cell lines and lack of toxicity to normal human fibroblasts, imipridones ONC206 and ONC212 were prioritized for further study. Both analogs inhibited colony formation, and induced apoptosis and downstream signaling that involves the integrated stress response and Akt/ERK, similar to ONC201. Compared to ONC201, ONC206 demonstrated improved inhibition of cell migration while ONC212 exhibited rapid kinetics of activity. ONC212 was further tested in &gt;1000 human cancer cell lines <i>in vitro</i> and evaluated for safety and anti-tumor efficacy <i>in vivo</i>. ONC212 exhibited broad-spectrum efficacy at nanomolar concentrations across solid tumors and hematological malignancies. Skin cancer emerged as a tumor type with improved efficacy relative to ONC201. Orally administered ONC212 displayed potent anti-tumor effects <i>in vivo</i>, a broad therapeutic window and a favorable PK profile. ONC212 was efficacious <i>in vivo</i> in BRAF V600E melanoma models that are less sensitive to ONC201. Based on these findings, ONC212 warrants further development as a drug candidate. It is clear that therapeutic utility extends beyond ONC201 to include additional imipridones.
DOI: 10.6084/m9.figshare.4993868.v2
title: Preclinical evaluation of the imipridone family, analogs of clinical stage anti-cancer small molecule ONC201, reveals potent anti-cancer effects of ONC212

description: Anti-cancer small molecule ONC201 upregulates the integrated stress response (ISR) and acts as a dual inactivator of Akt/ERK, leading to TRAIL gene activation. ONC201 is under investigation in multiple clinical trials to treat patients with cancer. Given the unique imipridone core chemical structure of ONC201, we synthesized a series of analogs to identify additional compounds with distinct therapeutic properties. Several imipridones with a broad range of <i>in vitro</i> potencies were identified in an exploration of chemical derivatives. Based on <i>in vitro</i> potency in human cancer cell lines and lack of toxicity to normal human fibroblasts, imipridones ONC206 and ONC212 were prioritized for further study. Both analogs inhibited colony formation, and induced apoptosis and downstream signaling that involves the integrated stress response and Akt/ERK, similar to ONC201. Compared to ONC201, ONC206 demonstrated improved inhibition of cell migration while ONC212 exhibited rapid kinetics of activity. ONC212 was further tested in &gt;1000 human cancer cell lines <i>in vitro</i> and evaluated for safety and anti-tumor efficacy <i>in vivo</i>. ONC212 exhibited broad-spectrum efficacy at nanomolar concentrations across solid tumors and hematological malignancies. Skin cancer emerged as a tumor type with improved efficacy relative to ONC201. Orally administered ONC212 displayed potent anti-tumor effects <i>in vivo</i>, a broad therapeutic window and a favorable PK profile. ONC212 was efficacious <i>in vivo</i> in BRAF V600E melanoma models that are less sensitive to ONC201. Based on these findings, ONC212 warrants further development as a drug candidate. It is clear that therapeutic utility extends beyond ONC201 to include additional imipridones.
DOI: 10.6084/m9.figshare.4993868.v1
title: Preclinical evaluation of the imipridone family, analogues of clinical stage anti-cancer small molecule ONC201, reveals potent anti-cancer effects of ONC212

description: Anti-cancer small molecule ONC201 upregulates the integrated stress response (ISR) and acts as a dual inactivator of Akt/ERK, leading to TRAIL gene activation. ONC201 is under investigation in multiple clinical trials to treat patients with cancer. Given the unique imipridone core chemical structure of ONC201, we synthesized a series of analogues to identify additional compounds with distinct therapeutic properties. Several imipridones with a broad range of <i>in vitro</i> potencies were identified in an exploration of chemical derivatives. Based on <i>in vitro</i> potency in human cancer cell lines and lack of toxicity to normal human fibroblasts, imipridones ONC206 and ONC212 were prioritized for further study. Both analogues inhibited colony formation, and induced apoptosis and downstream signaling that involves the integrated stress response and Akt/ERK, similar to ONC201. Compared to ONC201, ONC206 demonstrated improved inhibition of cell migration while ONC212 exhibited rapid kinetics of activity. ONC212 was further tested in &gt;1000 human cancer cell lines <i>in vitro</i> and evaluated for safety and anti-tumor efficacy <i>in vivo</i>. ONC212 exhibited broad-spectrum efficacy at nanomolar concentrations across solid tumors and hematological malignancies. Skin cancer emerged as a tumor type with improved efficacy relative to ONC201. Orally administered ONC212 displayed potent anti-tumor effects <i>in vivo</i>, a broad therapeutic window and a favorable PK profile. ONC212 was efficacious <i>in vivo</i> in BRAF V600E melanoma models that are less sensitive to ONC201. Based on these findings, ONC212 warrants further development as a drug candidate. It is clear that therapeutic utility extends beyond ONC201 to include additional imipridones.
DOI: 10.6084/m9.figshare.4993814
title: Honey bee mortality during corn planting in Southern Quebec.

description: Dataset for manuscript under review.<br>
DOI: 10.6084/m9.figshare.4993802
title: Supplementary File 1- Specimen table

description: A table of all of the specimens used and corresponding locality data from our manuscript "Translucent cuticle and setiferous patches in Megaspilidae (Hymenoptera: Ceraphronoidea)", submitted to the Journal of Hymenoptera Research.
DOI: 10.6084/m9.figshare.4993802.v1
title: Supplementary File 1- Specimen table

description: A table of all of the specimens used and corresponding locality data from our manuscript "Translucent cuticle and setiferous patches in Megaspilidae (Hymenoptera: Ceraphronoidea)", submitted to the Journal of Hymenoptera Research.
DOI: 10.6084/m9.figshare.4993814.v2
title: Honey bee mortality during corn planting in Southern Quebec.

description: Dataset for manuscript under review.<br>
DOI: 10.6084/m9.figshare.4993814.v1
title: Fileset for "Planting of neonicotinoid-coated corn raises honey bee mortality and setbacks colony development" (2017) Samson-Robert, O., Labrie, G., Chagnon, M. & Fournier, V. PeerJ.

description: Worldwide occurrences of honey bee colony losses have raised concerns about bee health and the sustainability of pollination-dependent crops. While multiple causal factors have been identified, seed coating with insecticides of the neonicotinoid family has been the focus of much discussion and research. Nonetheless, few studies have investigated the impacts of these insecticides under field conditions or in commercial beekeeping operations. Given that corn-seed coating constitutes the largest single use of neonicotinoid, our study compared honey bee mortality from commercial apiaries located in two different agricultural settings, i.e. corn-dominated areas and corn-free environments, during the corn planting season. Data was collected in 2012 and 2013 from 26 bee yards. Dead honey bees from five hives in each apiary were counted and collected, and samples were analyzed using a multi-residue LC-MS/MS method. Long-term effects on colony development were simulated based on a honey bee population dynamic model. Mortality survey showed that colonies located in a corn-dominated area had daily mortality counts 3.51 times those of colonies from corn crop-free sites. Chemical analyses revealed that honey bees were exposed to various agricultural pesticides during the corn planting season, but were primarily subjected to neonicotinoid compounds (54% of analysed samples contained clothianidin, and 31% contained both clothianidin and thiamethoxam). Performance development simulations performed on hive populations’ show that increased mortality during the corn planting season setbacks colony development and bears contributions to collapse risk but most of all, reduces the effectiveness and value of colonies for pollination services. Our results also have implications for the numerous large-scale and worldwide-cultivated crops that currently rely on pre-emptive use of neonicotinoid seed treatments.
DOI: 10.6084/m9.figshare.4993667
title: Sample size effects on the assessment of eukaryotic diversity and community structure in aquatic sediments using high-throughput sequencing

description: Data is 18S rRNA amplicons generated on an Illumina HiSeq (250-PE rapid run). <br>This is a methodological experiment where marine sediments have been subsampled using increasingly larger volumes of sediment from cores samples.<br>Data is from the following manuscript: <br>Nascimento, FJA, Lallias D, Bik, HM, Creer, S (submitted) Sample size effects on the assessment of eukaryotic diversity and community structure in aquatic sediments using high-throughput sequencing.
DOI: 10.6084/m9.figshare.4991741
title: Image cytometry

description: Raw multiwavelength cell scoring data of the post-pneumonectomy lung in controls, POD1, POD3, POD7 and POD14.
DOI: 10.6084/m9.figshare.4993541
title: Modeling the Ebola Zoonotic Dynamics: Interplay between Enviroclimatic Factors and Bat Ecology

description: The file data.zip contains the (compressed) data obtained in numerical simulations for generating Fig. 3 of the manuscript. The file contains 600 frames. The structure of each as describe in the file data.pdf
DOI: 10.6084/m9.figshare.4993541.v1
title: Modeling the Ebola Zoonotic Dynamics: Interplay between Enviroclimatic Factors and Bat Ecology

description: The file data.zip contains the (compressed) data obtained in numerical simulations for generating Fig. 3 of the manuscript. The file contains 600 frames. The structure of each as describe in the file data.pdf
DOI: 10.6084/m9.figshare.4991741.v1
title: Image cytometry

description: Raw multiwavelength cell scoring data of the post-pneumonectomy lung in controls, POD1, POD3, POD7 and POD14.
DOI: 10.6084/m9.figshare.4991087
title: Is rheumatoid arthritis associated with reduced immunogenicity of the influenza vaccination? A systematic review and meta-analysis

description: <b>Objective:</b> To determine whether immunogenicity and safety of the influenza vaccination in rheumatoid arthritis (RA) patients are significantly different from those in a healthy population. <b>Methods:</b> PubMed, MEDLINE, Embase, Cochrane Library and Web of Science were searched on 31 August 2016. Studies were included when they met the inclusion criteria. Two reviewers independently extracted data on study characteristics, methodological quality and outcomes. The primary outcome was seroprotection (SP) rate after immunization. <b>Results:</b> Thirteen studies were included. The SP rates did not significantly differ between the RA patients and healthy controls for the H3N2 (RR = 0.96, 95% CI, 0.82 to 1.13, <i>p</i> = .64) and B strain (RR = 0.95, 95% CI 0.84 to 1. 08, <i>p</i> = .44). Nevertheless, RA was associated with a significant decrease in SP rate for the H1N1 strain (RR = 0.72, 95% CI 0.60 to 0.86, <i>p</i> p = .04). <b>Conclusions:</b> Immunogenicity was significantly different between RA patients and healthy controls for the H1N1 strain, but not for the H3N2 or B strains. Adverse event rates were higher in RA patients. Adjuvant and special kinds of immunosuppressive biologics may play an important role in immunogenicity of inactivated influenza vaccines for RA patients.
DOI: 10.6084/m9.figshare.4991099
title: IMGpedia Dataset

description: IMGpedia is a large-scale linked dataset that incorporates visual information of the images from the Wikimedia Commons dataset: it brings together descriptors of the visual content of 15 million images, 450 million visual-similarity relations between those images, links to image metadata from DBpedia Commons, and links to the DBpedia resources associated with the images.
DOI: 10.6084/m9.figshare.4991087.v2
title: Is rheumatoid arthritis associated with reduced immunogenicity of the influenza vaccination? A systematic review and meta-analysis

description: <b>Objective:</b> To determine whether immunogenicity and safety of the influenza vaccination in rheumatoid arthritis (RA) patients are significantly different from those in a healthy population. <b>Methods:</b> PubMed, MEDLINE, Embase, Cochrane Library and Web of Science were searched on 31 August 2016. Studies were included when they met the inclusion criteria. Two reviewers independently extracted data on study characteristics, methodological quality and outcomes. The primary outcome was seroprotection (SP) rate after immunization. <b>Results:</b> Thirteen studies were included. The SP rates did not significantly differ between the RA patients and healthy controls for the H3N2 (RR = 0.96, 95% CI, 0.82 to 1.13, <i>p</i> = .64) and B strain (RR = 0.95, 95% CI 0.84 to 1. 08, <i>p</i> = .44). Nevertheless, RA was associated with a significant decrease in SP rate for the H1N1 strain (RR = 0.72, 95% CI 0.60 to 0.86, <i>p</i> p = .04). <b>Conclusions:</b> Immunogenicity was significantly different between RA patients and healthy controls for the H1N1 strain, but not for the H3N2 or B strains. Adverse event rates were higher in RA patients. Adjuvant and special kinds of immunosuppressive biologics may play an important role in immunogenicity of inactivated influenza vaccines for RA patients.