cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.19928721
title: Retinal changes in patients with acute lymphocytic leukemia (all): discussion of topic from a case report

description: ABSTRACT The Acute Lymphocytic Leukemia (ALL) is a disease characterized by a high survival rate, but the absolute number of children who die from it represents a large proportion of cases of infant deaths from cancer. The morbidity resulting from its treatment can leave sequelae in people with high life expectancy, making it extremely necessary to understand the pathogenesis of this disease, enabling the development of new treatments and reduction of sequelae caused by the disease. This early diagnosis is important to avoid ocular complications that may lead to low long-term visual acuity and to evaluate treatment relapses and determine the conducts.
DOI: 10.6084/m9.figshare.19928721.v1
title: Retinal changes in patients with acute lymphocytic leukemia (all): discussion of topic from a case report

description: ABSTRACT The Acute Lymphocytic Leukemia (ALL) is a disease characterized by a high survival rate, but the absolute number of children who die from it represents a large proportion of cases of infant deaths from cancer. The morbidity resulting from its treatment can leave sequelae in people with high life expectancy, making it extremely necessary to understand the pathogenesis of this disease, enabling the development of new treatments and reduction of sequelae caused by the disease. This early diagnosis is important to avoid ocular complications that may lead to low long-term visual acuity and to evaluate treatment relapses and determine the conducts.
DOI: 10.6084/m9.figshare.19928734
title: Bilateral retinal detachment – when the kidney meets the eye

description: ABSTRACT Exudative retinal detachment occurs when fluid accumulates between the neurosensory retina and the retinal pigment epithelium. Ocular diseases or multisystem conditions such as nephrotic syndrome may lead to exudative retinal detachment. This report describes a case of nephrotic syndrome secondary to minimal change disease, anasarca and bilateral serous macular detachment in an adult patient. A 75-year-old male patient presented to the emergency department with generalized edema, asthenia, and visual impairment. Medical history included a recent diagnosis of nephrotic syndrome secondary to minimal change disease, which had been controlled with corticosteroid therapy. At presentation, best corrected visual acuity was 20/100. Slit-lamp examination revealed xanthelasmas and mild bilateral eyelid edema and chemosis. Dilated fundus examination confirmed bilateral macular detachment. The patient did not respond to diuretic therapy. Ttherefore, hemodialysis was started. Two months later, visual acuity improved to 20/25 and near normal restoration of retinal anatomy was achieved, with concurrent remission of proteinuria. Exudative retinal detachment is a multifactorial condition. However, in diseases associated with severe hypoalbuminemia, such as nephrotic syndrome, low oncotic pressure in choroidal vessels and high interstitial pressure in the choroid may explain retinal detachment. Patients with chronic kidney disease carry a high risk of ophthalmic disease development. Several mechanisms that affect ocular vessels, the retina and the choroid are thought to be involved. A multidisciplinary approach is crucial to resolve the ophthalmic condition and improve overall health.
DOI: 10.6084/m9.figshare.19928734.v1
title: Bilateral retinal detachment – when the kidney meets the eye

description: ABSTRACT Exudative retinal detachment occurs when fluid accumulates between the neurosensory retina and the retinal pigment epithelium. Ocular diseases or multisystem conditions such as nephrotic syndrome may lead to exudative retinal detachment. This report describes a case of nephrotic syndrome secondary to minimal change disease, anasarca and bilateral serous macular detachment in an adult patient. A 75-year-old male patient presented to the emergency department with generalized edema, asthenia, and visual impairment. Medical history included a recent diagnosis of nephrotic syndrome secondary to minimal change disease, which had been controlled with corticosteroid therapy. At presentation, best corrected visual acuity was 20/100. Slit-lamp examination revealed xanthelasmas and mild bilateral eyelid edema and chemosis. Dilated fundus examination confirmed bilateral macular detachment. The patient did not respond to diuretic therapy. Ttherefore, hemodialysis was started. Two months later, visual acuity improved to 20/25 and near normal restoration of retinal anatomy was achieved, with concurrent remission of proteinuria. Exudative retinal detachment is a multifactorial condition. However, in diseases associated with severe hypoalbuminemia, such as nephrotic syndrome, low oncotic pressure in choroidal vessels and high interstitial pressure in the choroid may explain retinal detachment. Patients with chronic kidney disease carry a high risk of ophthalmic disease development. Several mechanisms that affect ocular vessels, the retina and the choroid are thought to be involved. A multidisciplinary approach is crucial to resolve the ophthalmic condition and improve overall health.
DOI: 10.6084/m9.figshare.19928737.v1
title: Femtosecond laser-assisted anterior lamellar keratoplasty with suboptimal outcomes: a case series

description: ABSTRACT Objective To identify preoperative clinical characteristics of patients undergoing femtosecond laser-assisted anterior lamellar keratoplasty who failed to achieve optimal postoperative visual outcomes. Methods In this single-center, retrospective case series, patients who underwent femtosecond laser-assisted anterior lamellar keratoplasty between 2013 and 2018 were included if they required graft revision, subsequent corneal procedure, or additional postoperative visits for a femtosecond laser-assisted anterior lamellar keratoplasty-related issue. Visual outcomes assessed included best-corrected visual acuities and postoperative corneal astigmatism. Results Eight eyes of eight patients meeting the above criteria were included. Mean patient age was 64.5 years (range, 21 to 89 years). Mean included preoperative best-corrected visual acuities was one logarithm of the minimum angle of resolution (range, 0.3 logarithm of the minimum angle of resolution to counting fingers). Indications for femtosecond laser-assisted anterior lamellar keratoplasty included anterior stromal scarring due to viral keratitis (two cases), bacterial keratitis (one case), chronic epithelial defect (one case), Avellino dystrophy (one case), trauma (one case), and chronic endothelial failure (two cases). Six patients had history of prior intraocular surgeries including phacoemulsification (four cases), pars plana vitrectomy (one case), endothelial keratoplasty (two cases), and trabeculectomy (one case). Mean included best-corrected visual acuities at most recent follow-up was one logarithm of the minimum angle of resolution (range zero logarithm of the minimum angle of resolution to hand movements) representing improvement or stability in six of eight patients. Visually significant corneal astigmatism was present in four of eight patients. Post-femtosecond laser-assisted anterior lamellar keratoplasty procedures included graft repositioning, arcuate keratotomy, phacoemulsification, and regraft. Conclusion While femtosecond laser-assisted anterior lamellar keratoplasty offers a less-invasive treatment option compared to penetrating keratoplasty, intraoperative and postoperative management can be complex. Femtosecond laser-assisted anterior lamellar keratoplasty in patients with history of prior endothelial keratoplasty or ongoing ocular comorbidities should be pursued with caution.
DOI: 10.6084/m9.figshare.19928737
title: Femtosecond laser-assisted anterior lamellar keratoplasty with suboptimal outcomes: a case series

description: ABSTRACT Objective To identify preoperative clinical characteristics of patients undergoing femtosecond laser-assisted anterior lamellar keratoplasty who failed to achieve optimal postoperative visual outcomes. Methods In this single-center, retrospective case series, patients who underwent femtosecond laser-assisted anterior lamellar keratoplasty between 2013 and 2018 were included if they required graft revision, subsequent corneal procedure, or additional postoperative visits for a femtosecond laser-assisted anterior lamellar keratoplasty-related issue. Visual outcomes assessed included best-corrected visual acuities and postoperative corneal astigmatism. Results Eight eyes of eight patients meeting the above criteria were included. Mean patient age was 64.5 years (range, 21 to 89 years). Mean included preoperative best-corrected visual acuities was one logarithm of the minimum angle of resolution (range, 0.3 logarithm of the minimum angle of resolution to counting fingers). Indications for femtosecond laser-assisted anterior lamellar keratoplasty included anterior stromal scarring due to viral keratitis (two cases), bacterial keratitis (one case), chronic epithelial defect (one case), Avellino dystrophy (one case), trauma (one case), and chronic endothelial failure (two cases). Six patients had history of prior intraocular surgeries including phacoemulsification (four cases), pars plana vitrectomy (one case), endothelial keratoplasty (two cases), and trabeculectomy (one case). Mean included best-corrected visual acuities at most recent follow-up was one logarithm of the minimum angle of resolution (range zero logarithm of the minimum angle of resolution to hand movements) representing improvement or stability in six of eight patients. Visually significant corneal astigmatism was present in four of eight patients. Post-femtosecond laser-assisted anterior lamellar keratoplasty procedures included graft repositioning, arcuate keratotomy, phacoemulsification, and regraft. Conclusion While femtosecond laser-assisted anterior lamellar keratoplasty offers a less-invasive treatment option compared to penetrating keratoplasty, intraoperative and postoperative management can be complex. Femtosecond laser-assisted anterior lamellar keratoplasty in patients with history of prior endothelial keratoplasty or ongoing ocular comorbidities should be pursued with caution.
DOI: 10.6084/m9.figshare.19928739.v1
title: Comparison of fascia lata, silicone sling and polypropylene suture in frontalis suspension

description: ABSTRACT Objective To compare efficacy, durability and postoperative complications of frontal suspension with the use of autologous fascia lata, silicone sling or polypropylene suture. Methods A descriptive, analytical, observational and retrospective study of patients with severe ptosis who underwent frontalis suspension, during a 2-year period. Data analyzed included comparative margin to reflex distance, palpebral fissure, and complications. Results Fascia lata was the material that provided the best results of margin to reflex distance and palpebral fissure in the postoperative analysis after one year. In addition, it had the lowest rate of complications (10%) and no cases of infection. Silicone sling ranked second in best results (5% of infection and 5% of recurrence), followed by polypropylene suture (15% of undercorrection and 5% of recurrence). Conclusion Fascia lata was shown to be superior to other materials regarding durability of the effect and improvement of ptosis, as well as lower rate of complications.
DOI: 10.6084/m9.figshare.19928739
title: Comparison of fascia lata, silicone sling and polypropylene suture in frontalis suspension

description: ABSTRACT Objective To compare efficacy, durability and postoperative complications of frontal suspension with the use of autologous fascia lata, silicone sling or polypropylene suture. Methods A descriptive, analytical, observational and retrospective study of patients with severe ptosis who underwent frontalis suspension, during a 2-year period. Data analyzed included comparative margin to reflex distance, palpebral fissure, and complications. Results Fascia lata was the material that provided the best results of margin to reflex distance and palpebral fissure in the postoperative analysis after one year. In addition, it had the lowest rate of complications (10%) and no cases of infection. Silicone sling ranked second in best results (5% of infection and 5% of recurrence), followed by polypropylene suture (15% of undercorrection and 5% of recurrence). Conclusion Fascia lata was shown to be superior to other materials regarding durability of the effect and improvement of ptosis, as well as lower rate of complications.
DOI: 10.6084/m9.figshare.19928740
title: Ultra-wide field imaging for ophthalmological evaluation of pregnant women with positive serology for toxoplasmosis

description: ABSTRACT Objective To screen pregnant women with positive serological results for toxoplasmosis using non-invasive, ultra-wide field retinal imaging. Methods Prospective, descriptive longitudinal study including pregnant women with positive serological results for toxoplasmosis seen at three maternal care reference units located in Belém (PA), in the Brazilian Amazon. Patient data were collected via interview. Comprehensive eye examination, including best corrected visual acuity, biomicroscopy, tonometry and ultra-wide field imaging, was performed every three months. Results The sample comprised 36 pregnant women. Of these, 52% had a serological profile consistent with acute toxoplasmosis, whereas 48% had a serological profile consistent with immunity. Three pregnant women had signs of chorioretinitis on ultra-wide field imaging in the first trimester. An active lesion adjacent to a scarred lesion was detected in one patient. Only women with serological results consistent with acute toxoplasmosis were treated. Treatment with systemic corticosteroids was limited to the patient with active ocular lesion. Follow-up assessment revealed resolution of the ocular lesion and normalization of visual acuity (20/20). All newborns were examined. No signs of congenital toxoplasmosis were found. Conclusion Ophthalmological screening of pregnant women with positive serological results for toxoplasmosis should be standardized to prevent vision loss in newborns and mothers. Ultra-wide field retinal imaging can be used as an initial screening strategy to support referral for specialized care, particularly in areas with limited access ophthalmology services.
DOI: 10.6084/m9.figshare.19928740.v1
title: Ultra-wide field imaging for ophthalmological evaluation of pregnant women with positive serology for toxoplasmosis

description: ABSTRACT Objective To screen pregnant women with positive serological results for toxoplasmosis using non-invasive, ultra-wide field retinal imaging. Methods Prospective, descriptive longitudinal study including pregnant women with positive serological results for toxoplasmosis seen at three maternal care reference units located in Belém (PA), in the Brazilian Amazon. Patient data were collected via interview. Comprehensive eye examination, including best corrected visual acuity, biomicroscopy, tonometry and ultra-wide field imaging, was performed every three months. Results The sample comprised 36 pregnant women. Of these, 52% had a serological profile consistent with acute toxoplasmosis, whereas 48% had a serological profile consistent with immunity. Three pregnant women had signs of chorioretinitis on ultra-wide field imaging in the first trimester. An active lesion adjacent to a scarred lesion was detected in one patient. Only women with serological results consistent with acute toxoplasmosis were treated. Treatment with systemic corticosteroids was limited to the patient with active ocular lesion. Follow-up assessment revealed resolution of the ocular lesion and normalization of visual acuity (20/20). All newborns were examined. No signs of congenital toxoplasmosis were found. Conclusion Ophthalmological screening of pregnant women with positive serological results for toxoplasmosis should be standardized to prevent vision loss in newborns and mothers. Ultra-wide field retinal imaging can be used as an initial screening strategy to support referral for specialized care, particularly in areas with limited access ophthalmology services.
DOI: 10.6084/m9.figshare.19928742.v1
title: Heterochromia: a review of conditions that may affect iris pigmentation

description: ABSTRACT The iris is responsible for eye color and controls the amount of light that enters the eye through the pupil. Variation in each individual’s genes, besides the quantity and quality of melanin in the iris, determine eye color. Heterochromia is characterized by different colors of irises in the same individual, and it is benign in most cases. There are basically three types of heterochromia: central, partial and complete. Heterochromia can be caused by genetic and congenital alterations, which may or may not be related to specific conditions, such as Sturge-Weber syndrome, Waardenburg syndrome, Parry-Romberg syndrome and congenital Horner syndrome. It may be associated to acquired causes like diseases or injuries, such as eye trauma and intraocular foreign bodies, use of some topical medications, ocular siderosis, iritis or uveitis, such as Fuchs´ uveitis, among others. When assessing a patient with heterochromia, one must understand the context and clinical course of this signal, since it may be a benign pigmentation disorder or there may be an underlying disease, which requires specific therapy. This literature review article was set out to address the main etiologies related to heterochromia, in addition to describing the anatomy and physiology of the iris color and the pathophysiology of possible alterations.
DOI: 10.6084/m9.figshare.19928742
title: Heterochromia: a review of conditions that may affect iris pigmentation

description: ABSTRACT The iris is responsible for eye color and controls the amount of light that enters the eye through the pupil. Variation in each individual’s genes, besides the quantity and quality of melanin in the iris, determine eye color. Heterochromia is characterized by different colors of irises in the same individual, and it is benign in most cases. There are basically three types of heterochromia: central, partial and complete. Heterochromia can be caused by genetic and congenital alterations, which may or may not be related to specific conditions, such as Sturge-Weber syndrome, Waardenburg syndrome, Parry-Romberg syndrome and congenital Horner syndrome. It may be associated to acquired causes like diseases or injuries, such as eye trauma and intraocular foreign bodies, use of some topical medications, ocular siderosis, iritis or uveitis, such as Fuchs´ uveitis, among others. When assessing a patient with heterochromia, one must understand the context and clinical course of this signal, since it may be a benign pigmentation disorder or there may be an underlying disease, which requires specific therapy. This literature review article was set out to address the main etiologies related to heterochromia, in addition to describing the anatomy and physiology of the iris color and the pathophysiology of possible alterations.
DOI: 10.6084/m9.figshare.19928743
title: Evaluation of efficacy of gonioscopy-assisted transluminal trabeculotomy in advanced-stage and non-advanced stage glaucoma

description: ABSTRACT Objective To evaluate efficacy of gonioscopy-assisted transluminal trabeculotomy and relate to severity of glaucoma. Methods A retrospective analysis of medical records of patients submitted to gonioscopy-assisted transluminal trabeculotomy, at a private hospital, from 2019 to 2021. Results A total of 20 were submitted to gonioscopy-assisted transluminal trabeculotomy (2 eyes) or facectomy and gonioscopy-assisted transluminal trabeculotomy (18 eyes). Patients with advanced-stage disease achieved a decrease by 5 mmHg (26.5%) in IOP, with a reduction of 2.3 drugs, and eyes with mild or moderate glaucoma showed a drop by 8 mmHg (40%) in mean IOP and of 2.1 drugs. Half of the operated eyes had hyphema in the first days as the main surgical complication. Conclusion Gonioscopy-assisted transluminal trabeculotomy is an effective procedure to reduce IOP and the number of drugs being used, with greater IOP decrease in eyes with mild/moderate glaucoma.
DOI: 10.6084/m9.figshare.19928743.v1
title: Evaluation of efficacy of gonioscopy-assisted transluminal trabeculotomy in advanced-stage and non-advanced stage glaucoma

description: ABSTRACT Objective To evaluate efficacy of gonioscopy-assisted transluminal trabeculotomy and relate to severity of glaucoma. Methods A retrospective analysis of medical records of patients submitted to gonioscopy-assisted transluminal trabeculotomy, at a private hospital, from 2019 to 2021. Results A total of 20 were submitted to gonioscopy-assisted transluminal trabeculotomy (2 eyes) or facectomy and gonioscopy-assisted transluminal trabeculotomy (18 eyes). Patients with advanced-stage disease achieved a decrease by 5 mmHg (26.5%) in IOP, with a reduction of 2.3 drugs, and eyes with mild or moderate glaucoma showed a drop by 8 mmHg (40%) in mean IOP and of 2.1 drugs. Half of the operated eyes had hyphema in the first days as the main surgical complication. Conclusion Gonioscopy-assisted transluminal trabeculotomy is an effective procedure to reduce IOP and the number of drugs being used, with greater IOP decrease in eyes with mild/moderate glaucoma.
DOI: 10.6084/m9.figshare.19928745
title: Subconjunctival adalimumab for treatment of dry eye disease in Sjögren’s syndrome

description: ABSTRACT Objective To describe the use of subconjuctival administration of the anti-tumor necrosis factor agent adalimumab for treatment of dry eye in patients with Sjögren’s syndrome, and to investigate conjunctival healing. Methods Prospective, nonrandomized, noncomparative interventional case series including consecutive patients with Sjögren’s syndrome and dry eye disease treated with subconjunctival adalimumab, who were refractory to conventional treatment. Patients with infectious ocular surface involvement or structural changes in the tear pathway or eyelids were excluded. Data recorded included age, sex, lissamine green staining pattern, Schirmer test results, intraocular pressure, conjunctival mobility, tear break up time and findings of biomicroscopic evaluation, following fluorescein dye instillation. The Ocular Surface Disease Index questionnaire validated for the Portuguese language was used for subjective assessment of patients. Results Eleven eyes of eight patients were studied. Mean patient age was 53±13.4 years. Patients were treated with subconjunctival injection of 0.03 mL of adalimumab and followed for 90 days thereafter. There were no statistically significant objective improvement (objective tests results; p&gt;0.05) and no statistically significant changes in intraocular pressure (p=0.11). Questionnaire responses revealed a significant improvement in ocular symptoms (p=0.002). Conclusion Based on the Ocular Surface Disease Index questionnaire, subconjunctival administration of adalimumab improved dry eye symptoms. However, objective assessments failed to reveal statistically significant improvements.