cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.5281/zenodo.16944486
title: A Universal Mechanistic Mathematical Model of Parasite Load and Quorum Hijack as Hidden Drivers of ICD-10 Chronic Disease Burden in High-Income Settings

description: A Universal Mechanistic Mathematical Model of Parasite Load and Quorum Hijack as Hidden Drivers of ICD-10 Chronic Disease Burden in High-Income Settings

Authors: Iron Knot Enterprises LLC (Anonymous)

Description:

This study introduces a universal, falsifiable, mechanistic mathematical framework positing that parasite load serves as a hidden substrate driving a significant subset of chronic disease burdens coded under ICD-10 in high-income countries. Grounded in the One Health paradigm, the model integrates host-parasite dynamics, overdispersed behavioral amplification factors, zoonotic analogues, and parasite-induced immunomodulation to derive human reproduction numbers from livestock parasitology and human epidemiological data. It hypothesizes that modern behavioral patterns—such as sexual contact, communal substance use, and high-density service labor—amplify transmission beyond standard hygiene models, with parasite biomass acting as a universal driver of oncogenic and metabolic risks via a novel “quorum hijack” mechanism. Supported by systematic meta-analyses and case studies documenting disease reversal post-antiparasitic treatment, the model captures equilibria, stability, cancer hazard amplification, and ICD-10 attribution. A field-testable protocol using qPCR, metagenomic screening, and structured reversal validation is proposed, designed for sensitivity analysis and parameter fitting. This work offers testable predictions and actionable public health recommendations, with all data and code available in the description field of the publication platform to ensure reproducibility. The study targets researchers, clinicians, and policymakers to advance understanding and management of neglected parasitic infections.

Keywords: Parasite load, quorum hijack, ICD-10, chronic disease, One Health, mathematical modeling, zoonotic diseases, meta-analysis, public health, anthelmintic therapy

License: Creative Commons Attribution 4.0 International (CC BY 4.0)

Publication Date: September 16, 2025

DOI: 10.5281/zenodo.17136625

Notes: This is Version 3 of the manuscript, ready for peer review. Supplementary materials, including meta-analysis datasets and Python code, will be provided in the description field of the publication platform. Collaborative efforts under One Health frameworks are encouraged to validate the model through multi-site randomized controlled trials.
DOI: 10.5281/zenodo.17136625
title: A Universal Mechanistic Mathematical Model of Parasite Load and Quorum Hijack as Hidden Drivers of ICD-10 Chronic Disease Burden in High-Income Settings

description: A Universal Mechanistic Mathematical Model of Parasite Load and Quorum Hijack as Hidden Drivers of ICD-10 Chronic Disease Burden in High-Income Settings

Authors: Iron Knot Enterprises LLC (Anonymous)

Description:

This study introduces a universal, falsifiable, mechanistic mathematical framework positing that parasite load serves as a hidden substrate driving a significant subset of chronic disease burdens coded under ICD-10 in high-income countries. Grounded in the One Health paradigm, the model integrates host-parasite dynamics, overdispersed behavioral amplification factors, zoonotic analogues, and parasite-induced immunomodulation to derive human reproduction numbers from livestock parasitology and human epidemiological data. It hypothesizes that modern behavioral patterns—such as sexual contact, communal substance use, and high-density service labor—amplify transmission beyond standard hygiene models, with parasite biomass acting as a universal driver of oncogenic and metabolic risks via a novel “quorum hijack” mechanism. Supported by systematic meta-analyses and case studies documenting disease reversal post-antiparasitic treatment, the model captures equilibria, stability, cancer hazard amplification, and ICD-10 attribution. A field-testable protocol using qPCR, metagenomic screening, and structured reversal validation is proposed, designed for sensitivity analysis and parameter fitting. This work offers testable predictions and actionable public health recommendations, with all data and code available in the description field of the publication platform to ensure reproducibility. The study targets researchers, clinicians, and policymakers to advance understanding and management of neglected parasitic infections.

Keywords: Parasite load, quorum hijack, ICD-10, chronic disease, One Health, mathematical modeling, zoonotic diseases, meta-analysis, public health, anthelmintic therapy

License: Creative Commons Attribution 4.0 International (CC BY 4.0)

Publication Date: September 16, 2025

DOI: 10.5281/zenodo.17136625

Notes: This is Version 3 of the manuscript, ready for peer review. Supplementary materials, including meta-analysis datasets and Python code, will be provided in the description field of the publication platform. Collaborative efforts under One Health frameworks are encouraged to validate the model through multi-site randomized controlled trials.
DOI: 10.15468/dl.qbdq5j
title: Occurrence Download

description: A dataset containing 969 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is Colombia",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "TaxonKey is Hesperomeles goudotiana"
 ]
}

 The dataset includes 969 records from 68 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0008339-250914085247600/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.63m69b
title: Occurrence Download

description: A dataset containing 17 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Vasticardium flavum",
 "HasCoordinate is true",
 "BasisOfRecord is one of (Observation, Machine Observation, Human Observation, Occurrence evidence)",
 {
 "not" : {
 "OccurrenceStatus" : [
 "is one of (Absent)"
 ]
 }
 }
 ]
}

 The dataset includes 17 records from 8 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0008340-250914085247600/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.s6kba7
title: Occurrence Download

description: A dataset containing 179 species occurrences available in GBIF matching the query:
{
 "and" : [
 "BasisOfRecord is Specimen",
 "Country is Mexico",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 "TaxonKey is Solanum grayi"
 ]
}

 The dataset includes 179 records from 30 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0008342-250914085247600/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.c2uv2t
title: Occurrence Download

description: A dataset containing 54615 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Continent is one of (North America, South America)",
 "GbifRegion is North America",
 "OccurrenceStatus is Present",
 "TaxonKey is Castor canadensis"
 ]
}

 The dataset includes 54615 records from 138 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0008301-250914085247600/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.3qe4u5
title: Occurrence Download

description: A dataset containing 11 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Phalaris brachystachys",
 "Country is Germany",
 "HasCoordinate is true"
 ]
}

 The dataset includes 11 records from 4 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0008344-250914085247600/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.6fv3jr
title: Occurrence Download

description: A dataset containing 1 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Phalaris brachystachys",
 "Country is Mexico",
 "HasCoordinate is true"
 ]
}

 The dataset includes 1 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0008345-250914085247600/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.vrumgb
title: Occurrence Download

description: A dataset containing 3 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Phalaris brachystachys",
 "Country is Denmark",
 "HasCoordinate is true"
 ]
}

 The dataset includes 3 records from 2 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0008343-250914085247600/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.kxngdr
title: Occurrence Download

description: A dataset containing 1 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Danionidae",
 "HasCoordinate is true"
 ]
}

 The dataset includes 1 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0008346-250914085247600/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.v7jnem
title: Occurrence Download

description: A dataset containing 7 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Vasticardium orbita",
 "HasCoordinate is true",
 "BasisOfRecord is one of (Observation, Machine Observation, Human Observation, Occurrence evidence)",
 {
 "not" : {
 "OccurrenceStatus" : [
 "is one of (Absent)"
 ]
 }
 }
 ]
}

 The dataset includes 7 records from 2 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0008347-250914085247600/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.7whbvn
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Monopterus desilvai)",
 "BasisOfRecord is one of (Specimen, Literature Occurrence, Human Observation, Observation)",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "Year is greater than or equal to 1991",
 "Year is less than or equal to 2025"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0008348-250914085247600/datasets/export for details.
DOI: 10.15468/dl.hsywg8
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Phalaris brachystachys",
 "Country is Poland",
 "HasCoordinate is true"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0008351-250914085247600/datasets/export for details.
DOI: 10.15468/dl.yayt2a
title: Occurrence Download

description: A dataset containing 171 species occurrences available in GBIF matching the query:
{
 "and" : [
 "BasisOfRecord is Specimen",
 "Country is Mexico",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 "TaxonKey is Solanum refractum"
 ]
}

 The dataset includes 171 records from 36 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0008349-250914085247600/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.ev8xtt
title: Occurrence Download

description: A dataset containing 17 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Phalaris brachystachys",
 "Country is Netherlands",
 "HasCoordinate is true"
 ]
}

 The dataset includes 17 records from 2 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0008350-250914085247600/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.rrss2e
title: Occurrence Download

description: A dataset containing 45 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Phalaris brachystachys",
 "Country is United States of America",
 "HasCoordinate is true"
 ]
}

 The dataset includes 45 records from 14 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0008352-250914085247600/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.3957yf
title: Occurrence Download

description: A dataset containing 277144 species occurrences available in GBIF matching the query:
{
 "and" : [
 "BasisOfRecord is one of (Human Observation, Specimen, Material sample, Material citation, Machine Observation)",
 "GadmGid is USA.6_1",
 "TaxonKey is Hymenoptera"
 ]
}

 The dataset includes 277144 records from 95 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0008275-250914085247600/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.rz7x6s
title: Occurrence Download

description: A dataset containing 189 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Vasticardium pectiniforme",
 "HasCoordinate is true",
 "BasisOfRecord is one of (Observation, Machine Observation, Human Observation, Occurrence evidence)",
 {
 "not" : {
 "OccurrenceStatus" : [
 "is one of (Absent)"
 ]
 }
 }
 ]
}

 The dataset includes 189 records from 7 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0008353-250914085247600/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.5281/zenodo.13735877
title: Type III interferons may suppress viral infections by triggering cell death -- Imaging Dataset

description: This dataset accompanies the article "Type III interferons may suppress viral infections by triggering cell death". Earlier version is available as a preprint, https://doi.org/10.1101/2024.09.09.612051. The updated dataset includes quantifications for Figure 7C and Figure 7D.
DOI: 10.5281/zenodo.17122542
title: Type III interferons may suppress viral infections by triggering cell death -- Imaging Dataset

description: This dataset accompanies the article "Type III interferons may suppress viral infections by triggering cell death". Earlier version is available as a preprint, https://doi.org/10.1101/2024.09.09.612051. The updated dataset includes quantifications for Figure 7C and Figure 7D.
DOI: 10.15468/dl.w85ygc
title: Occurrence Download

description: A dataset containing 1 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Iberochondrostoma almacai)",
 "BasisOfRecord is one of (Specimen, Literature Occurrence, Human Observation, Observation)",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "Year is greater than or equal to 1991",
 "Year is less than or equal to 2025"
 ]
}

 The dataset includes 1 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0008355-250914085247600/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.5gnssb
title: Occurrence Download

description: A dataset containing 167 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Phalaris canariensis",
 "Country is Austria",
 "HasCoordinate is true"
 ]
}

 The dataset includes 167 records from 13 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0008356-250914085247600/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.mgptmd
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Phalaris canariensis",
 "Country is Belarus",
 "HasCoordinate is true"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0008357-250914085247600/datasets/export for details.
DOI: 10.15468/dl.vze6km
title: Occurrence Download

description: A dataset containing 17 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Vasticardium subrugosum",
 "HasCoordinate is true",
 "BasisOfRecord is one of (Observation, Machine Observation, Human Observation, Occurrence evidence)",
 {
 "not" : {
 "OccurrenceStatus" : [
 "is one of (Absent)"
 ]
 }
 }
 ]
}

 The dataset includes 17 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0008358-250914085247600/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.hp2ere
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Phalaris canariensis",
 "Country is Bosnia and Herzegovina",
 "HasCoordinate is true"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0008359-250914085247600/datasets/export for details.
DOI: 10.15468/dl.fyhgfz
title: Occurrence Download

description: A dataset containing 965 species occurrences available in GBIF matching the query:
{
 "and" : [
 "OccurrenceStatus is Present",
 "TaxonKey is Liocheles australasiae"
 ]
}

 The dataset includes 965 records from 31 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0008360-250914085247600/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.5517/ccdc.csd.cc2ksjvr
title: CCDC 2377075: Experimental Crystal Structure Determination

description: Related Article: Andrew W. Heard, Luca Pesce, Peter T. Gierth, Simone Adorinni, Tanya K. Ronson, Barbara Rossi, John D. Thoburn, Tomas Deingruber, Martin Welch, David R. Spring, Silvia Marchesan, Giovanni M. Pavan, Jonathan R. Nitschke|2025|J.Am.Chem.Soc.|147|30842|doi:10.1021/jacs.5c07271
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2ktyjw
title: CCDC 2378429: Experimental Crystal Structure Determination

description: Related Article: Andrew W. Heard, Luca Pesce, Peter T. Gierth, Simone Adorinni, Tanya K. Ronson, Barbara Rossi, John D. Thoburn, Tomas Deingruber, Martin Welch, David R. Spring, Silvia Marchesan, Giovanni M. Pavan, Jonathan R. Nitschke|2025|J.Am.Chem.Soc.|147|30842|doi:10.1021/jacs.5c07271
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2nv7g7
title: CCDC 2468079: Experimental Crystal Structure Determination

description: Related Article: Bin Song, Pengxiang Gao, Feng Zhao, Ruizong Wang, Bingcheng Hu, Chong Zhang|2025|Org.Lett.|27|9489|doi:10.1021/acs.orglett.5c02976
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.15468/dl.z4s26n
title: Occurrence Download

description: A dataset containing 17 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Vepricardium asiaticum",
 "HasCoordinate is true",
 "BasisOfRecord is one of (Observation, Machine Observation, Human Observation, Occurrence evidence)",
 {
 "not" : {
 "OccurrenceStatus" : [
 "is one of (Absent)"
 ]
 }
 }
 ]
}

 The dataset includes 17 records from 2 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0008362-250914085247600/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.47urca
title: Occurrence Download

description: A dataset containing 49 species occurrences available in GBIF matching the query:
{
 "and" : [
 "BasisOfRecord is Specimen",
 "Country is Mexico",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 "TaxonKey is Stachys keerlii"
 ]
}

 The dataset includes 49 records from 17 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0008363-250914085247600/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.jtt788
title: Occurrence Download

description: A dataset containing 70 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Phalaris canariensis",
 "Country is Canada",
 "HasCoordinate is true"
 ]
}

 The dataset includes 70 records from 17 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0008365-250914085247600/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.p56xg5
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Phalaris canariensis",
 "Country is Bulgaria",
 "HasCoordinate is true"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0008364-250914085247600/datasets/export for details.
DOI: 10.15468/dl.zpju7q
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Phalaris canariensis",
 "Country is Cuba",
 "HasCoordinate is true"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0008366-250914085247600/datasets/export for details.
DOI: 10.15468/dl.t4ktdv
title: Occurrence Download

description: A dataset containing 513 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is Colombia",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "TaxonKey is Meriania nobilis"
 ]
}

 The dataset includes 513 records from 36 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0008368-250914085247600/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.