cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.29545301.v1
title: Medical complications after acquired pediatric injury to the Central nervous system: a scoping review

description: This scoping review aims to give an overview of the literature describing medical complications in children from 2 to 17 years, arising in the subacute and chronic phases after pediatric CNS injury, and to identify knowledge gaps on the subject. Our scoping review of publications in databases Embase and Medline follows the guidelines of Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA). We identified 11,497 articles published from 2000 to 2024. Initial screening reduced these to 1,220, which were reviewed in full-text, resulting in inclusion of 373 publications. Acquired brain injury was the most common CNS injury, with neoplastic etiology as the dominating subgroup. The majority of the articles were retrospective studies and case studies. Most publications reported one complication, and comprehensive approaches were scarce. Epilepsy and endocrine disturbances were the most frequently reported complications in brain injury patients, and scoliosis and pressure ulcers predominated in the spinal cord injury group. Despite a broad literature on the current topic, more longitudinal studies are needed, especially studies with a comprehensive approach to the medical complications that can occur after the acute phase in children with CNS injury. Extensive literature on medical complications after acquired pediatric injury to the central nervous system describes a wide range of complications.Rehabilitation clinicians can expect to face a large variety of medical complications that may impact the rehabilitation process.As the literature on comprehensive approaches to medical complications after the acute phase is scarce, clinicians must mainly rely on clinical experience or literature on adults. Extensive literature on medical complications after acquired pediatric injury to the central nervous system describes a wide range of complications. Rehabilitation clinicians can expect to face a large variety of medical complications that may impact the rehabilitation process. As the literature on comprehensive approaches to medical complications after the acute phase is scarce, clinicians must mainly rely on clinical experience or literature on adults.
DOI: 10.6084/m9.figshare.30001143
title: Rural health care providers’ experiences of providing care to children and youth with disabilities: a scoping review

description: Health care providers face many challenges with delivering care in rural areas. However, little is known about their experiences of providing care to marginalized populations, such as children with disabilities. The purpose of this study was to explore the experiences of health care providers serving rural children with disabilities. We conducted a scoping review following the Joanna Briggs Institute methodology and an inductive thematic approach involving eight international databases (Embase, CINAHL, JBI EBP, Healthstar, Ovid Medline, PsycINFO, Scopus, Web of Science). Of the 2631 screened articles, 31 met the inclusion criteria. The studies spanned across seven countries over a 24-year period. Our findings involved the following themes: (1) training and knowledge of childhood-onset disabilities (i.e., lack of training; adequate training); (2) communication (i.e., communication concerns; effective communication and rapport building with local communities); and (3) lack of resources, services and supports (i.e., staff shortages; travel and accessibility issues; challenges of intersectional needs of rural patients). Our findings emphasize the extent of the challenges that rural health care providers encounter in delivering care to children with disabilities. There is a critical need for further supports, resources and targeted interventions to recruit and retain rural health care providers. Clinicians providing services to children with disabilities in rural areas face many challenges.More training in childhood-onset disabilities and access to ongoing professional development is needed for rural clinicians.More efforts are necessary to recruit and retain rural health care providers serving youth with disabilities.Additional services, supports and resources are required to address gaps in care and to help optimize health outcomes for children and youth with disabilities. Clinicians providing services to children with disabilities in rural areas face many challenges. More training in childhood-onset disabilities and access to ongoing professional development is needed for rural clinicians. More efforts are necessary to recruit and retain rural health care providers serving youth with disabilities. Additional services, supports and resources are required to address gaps in care and to help optimize health outcomes for children and youth with disabilities.
DOI: 10.6084/m9.figshare.30001143.v1
title: Rural health care providers’ experiences of providing care to children and youth with disabilities: a scoping review

description: Health care providers face many challenges with delivering care in rural areas. However, little is known about their experiences of providing care to marginalized populations, such as children with disabilities. The purpose of this study was to explore the experiences of health care providers serving rural children with disabilities. We conducted a scoping review following the Joanna Briggs Institute methodology and an inductive thematic approach involving eight international databases (Embase, CINAHL, JBI EBP, Healthstar, Ovid Medline, PsycINFO, Scopus, Web of Science). Of the 2631 screened articles, 31 met the inclusion criteria. The studies spanned across seven countries over a 24-year period. Our findings involved the following themes: (1) training and knowledge of childhood-onset disabilities (i.e., lack of training; adequate training); (2) communication (i.e., communication concerns; effective communication and rapport building with local communities); and (3) lack of resources, services and supports (i.e., staff shortages; travel and accessibility issues; challenges of intersectional needs of rural patients). Our findings emphasize the extent of the challenges that rural health care providers encounter in delivering care to children with disabilities. There is a critical need for further supports, resources and targeted interventions to recruit and retain rural health care providers. Clinicians providing services to children with disabilities in rural areas face many challenges.More training in childhood-onset disabilities and access to ongoing professional development is needed for rural clinicians.More efforts are necessary to recruit and retain rural health care providers serving youth with disabilities.Additional services, supports and resources are required to address gaps in care and to help optimize health outcomes for children and youth with disabilities. Clinicians providing services to children with disabilities in rural areas face many challenges. More training in childhood-onset disabilities and access to ongoing professional development is needed for rural clinicians. More efforts are necessary to recruit and retain rural health care providers serving youth with disabilities. Additional services, supports and resources are required to address gaps in care and to help optimize health outcomes for children and youth with disabilities.
DOI: 10.6084/m9.figshare.30031807
title: Psychosocial aspects, chronic pain, fatigue and quality of life in individuals with Stickler syndrome: a scoping review and a cross-sectional questionnaire study

description: Stickler syndrome is a rare, hereditary connective tissue disorder characterized by visual, auditory, and musculoskeletal complications. Research on quality of life remains limited. This study aimed to: (i) explore existing literature on psychosocial aspects, pain, fatigue, and quality of life in individuals with Stickler syndrome, (ii) describe the impact of health complaints on daily living, contacts with healthcare- and social service systems and quality of life in a cohort of adults with Stickler syndrome. A combination of a systematic scoping review and a cross-sectional questionnaire study was utilized. The questionnaire included questions on demographics and health complaints, and several validated instruments: PROMIS-57, Satisfaction with Life Scale and LiSat-11. Only patients with a verified diagnosis were included. Of 43 articles read, five studies were included. Four addressed pain and one examined quality of life in children. Chronic pain was a prevalent finding, impacting daily functioning and quality of life. In the questionnaire (<i>n</i> = 24), 92% reported chronic pain, along with fatigue, anxiety symptoms, and reduced quality of life. Still, participants reported education, employment, and family life. Individuals with Stickler syndrome experience health challenges affecting various aspects of life. Further studies are needed to develop evidence-based practice for this group. Long-lasting pain, fatigue, and symptoms of anxiety were commonly reported by individuals with Stickler syndrome in this survey, suggesting an impact on daily life and quality of life.Rehabilitation professionals may consider systematic approaches to pain management to support participation in daily activitiesAddressing both physical symptoms such as fatigue and psychological concerns like symptoms of anxiety could help enhance overall well-beingAn interdisciplinary approach may be beneficial to meet the varied needs reported by this population Long-lasting pain, fatigue, and symptoms of anxiety were commonly reported by individuals with Stickler syndrome in this survey, suggesting an impact on daily life and quality of life. Rehabilitation professionals may consider systematic approaches to pain management to support participation in daily activities Addressing both physical symptoms such as fatigue and psychological concerns like symptoms of anxiety could help enhance overall well-being An interdisciplinary approach may be beneficial to meet the varied needs reported by this population
DOI: 10.6084/m9.figshare.30031807.v1
title: Psychosocial aspects, chronic pain, fatigue and quality of life in individuals with Stickler syndrome: a scoping review and a cross-sectional questionnaire study

description: Stickler syndrome is a rare, hereditary connective tissue disorder characterized by visual, auditory, and musculoskeletal complications. Research on quality of life remains limited. This study aimed to: (i) explore existing literature on psychosocial aspects, pain, fatigue, and quality of life in individuals with Stickler syndrome, (ii) describe the impact of health complaints on daily living, contacts with healthcare- and social service systems and quality of life in a cohort of adults with Stickler syndrome. A combination of a systematic scoping review and a cross-sectional questionnaire study was utilized. The questionnaire included questions on demographics and health complaints, and several validated instruments: PROMIS-57, Satisfaction with Life Scale and LiSat-11. Only patients with a verified diagnosis were included. Of 43 articles read, five studies were included. Four addressed pain and one examined quality of life in children. Chronic pain was a prevalent finding, impacting daily functioning and quality of life. In the questionnaire (<i>n</i> = 24), 92% reported chronic pain, along with fatigue, anxiety symptoms, and reduced quality of life. Still, participants reported education, employment, and family life. Individuals with Stickler syndrome experience health challenges affecting various aspects of life. Further studies are needed to develop evidence-based practice for this group. Long-lasting pain, fatigue, and symptoms of anxiety were commonly reported by individuals with Stickler syndrome in this survey, suggesting an impact on daily life and quality of life.Rehabilitation professionals may consider systematic approaches to pain management to support participation in daily activitiesAddressing both physical symptoms such as fatigue and psychological concerns like symptoms of anxiety could help enhance overall well-beingAn interdisciplinary approach may be beneficial to meet the varied needs reported by this population Long-lasting pain, fatigue, and symptoms of anxiety were commonly reported by individuals with Stickler syndrome in this survey, suggesting an impact on daily life and quality of life. Rehabilitation professionals may consider systematic approaches to pain management to support participation in daily activities Addressing both physical symptoms such as fatigue and psychological concerns like symptoms of anxiety could help enhance overall well-being An interdisciplinary approach may be beneficial to meet the varied needs reported by this population
DOI: 10.15468/qm6s96
title: Synopsis of the myrmecophilous genus Ecitonides Wasmann (Coleoptera, Staphylinidae, Paederinae), with description of two new species from Brazil

description: This dataset contains the digitized treatments in Plazi based on the original journal article Montanhini, Amanda, Żyła, Dagmara, Biffi, Gabriel (2026): Synopsis of the myrmecophilous genus Ecitonides Wasmann (Coleoptera, Staphylinidae, Paederinae), with description of two new species from Brazil. ZooKeys 1267: 283-314, DOI: 10.3897/zookeys.1267.175767AbstractThe Neotropical genus of myrmecophilous beetles, Ecitonides Wasmann, 1894 (Staphylinidae: Paederinae: Lathrobiini), currently includes nine valid species distributed in French Guiana, Suriname, Brazil, Peru, Paraguay, and Argentina. Members of this genus are notable for the tuberculate ornamentation on the head, thorax, and abdomen. Although little is known about the biology of these beetles, there are records of association with different species of army ants (Labidus Jurine, 1807 and Nomamyrmex Borgmeier, 1936). In this study, a detailed comparative morphological study of all available species for study was conducted, descriptions of two new species, Ecitonides colossus sp. nov. and Ecitonides splendidus sp. nov., are provided, and lectotypes for Ecitonides brevicornis Wasmann, 1900 and Ecitonides spectabilis Borgmeier, 1932 are designated. Diagnoses, illustrations, and photographs are given; an identification key is provided for all 11 species as well as new geographic distribution data. The aim of this study is to provide morphological data that will serve as a tool for a future investigation of the phylogenetic position of the genus and facilitate species recognition through diagnostic morphological characters and an identification key.
DOI: 10.6084/m9.figshare.31120663
title: S3A Figure

description: S3A Fig. Mitochondrial DNA is the likely cGAS ligand during lytic KSHV infection. BC-3 cells were treated with or without 20 μM dideoxycytidine (“ddC”) for 48 hours to deplete mitochondrial DNA (“mtDNA”), then treated with 20 ng/ml TPA for 48 hours to induce the lytic cycle (“lytic (+TPA)”), or vehicle (DMSO, “latent”). At the time of lytic induction, where indicated, the cells were also treated with 10 μM of the pan-caspase inhibitor IDN-6556 (“casp-i”). DNA was extracted and mtDNA levels were measured by qPCR, normalized to CCR5 nuclear DNA, and plotted relative to the untreated lytic+casp-i sample.ns = p&gt;0.05, ** = p&lt;0.01, **** = p&lt;0.0001. Two-Way ANOVA followed by Tukey’s post hoc multiple comparisons test for all experiments. n= 3 for all experiments.
DOI: 10.6084/m9.figshare.31120663.v1
title: S3A Figure

description: S3A Fig. Mitochondrial DNA is the likely cGAS ligand during lytic KSHV infection. BC-3 cells were treated with or without 20 μM dideoxycytidine (“ddC”) for 48 hours to deplete mitochondrial DNA (“mtDNA”), then treated with 20 ng/ml TPA for 48 hours to induce the lytic cycle (“lytic (+TPA)”), or vehicle (DMSO, “latent”). At the time of lytic induction, where indicated, the cells were also treated with 10 μM of the pan-caspase inhibitor IDN-6556 (“casp-i”). DNA was extracted and mtDNA levels were measured by qPCR, normalized to CCR5 nuclear DNA, and plotted relative to the untreated lytic+casp-i sample.ns = p&gt;0.05, ** = p&lt;0.01, **** = p&lt;0.0001. Two-Way ANOVA followed by Tukey’s post hoc multiple comparisons test for all experiments. n= 3 for all experiments.
DOI: 10.6084/m9.figshare.31120669
title: S3B Figure

description: S3B Fig. Mitochondrial DNA is the likely cGAS ligand during lytic KSHV infection. BC-3 cells were treated with or without 20 μM dideoxycytidine (“ddC”) for 48 hours to deplete mitochondrial DNA (“mtDNA”), then treated with 20 ng/ml TPA for 48 hours to induce the lytic cycle (“lytic (+TPA)”), or vehicle (DMSO, “latent”). At the time of lytic induction, where indicated, the cells were also treated with 10 μM of the pan-caspase inhibitor IDN-6556 (“casp-i”). RNA was extracted and IFN-β mRNA levels were measured by RT-qPCR, normalized to 18S rRNA, and plotted relative to the lytic+casp-i sample. ns = p&gt;0.05, ** = p&lt;0.01, **** = p&lt;0.0001. Two-Way ANOVA followed by Tukey’s post hoc multiple comparisons test for all experiments. n= 3 for all experiments.
DOI: 10.6084/m9.figshare.31120669.v1
title: S3B Figure

description: S3B Fig. Mitochondrial DNA is the likely cGAS ligand during lytic KSHV infection. BC-3 cells were treated with or without 20 μM dideoxycytidine (“ddC”) for 48 hours to deplete mitochondrial DNA (“mtDNA”), then treated with 20 ng/ml TPA for 48 hours to induce the lytic cycle (“lytic (+TPA)”), or vehicle (DMSO, “latent”). At the time of lytic induction, where indicated, the cells were also treated with 10 μM of the pan-caspase inhibitor IDN-6556 (“casp-i”). RNA was extracted and IFN-β mRNA levels were measured by RT-qPCR, normalized to 18S rRNA, and plotted relative to the lytic+casp-i sample. ns = p&gt;0.05, ** = p&lt;0.01, **** = p&lt;0.0001. Two-Way ANOVA followed by Tukey’s post hoc multiple comparisons test for all experiments. n= 3 for all experiments.
DOI: 10.6084/m9.figshare.31120585
title: S2D Figure

description: S2D Fig. Lentivirally established CMV promoter-driven tdTomato expression does not induce IFN-β in BC-3 cells and does not correlate with IFN-β expression. BC3-CMVp-tdTomato cells were treated with 20 ng/mL TPA for 48 hours to induce the lytic cycle (“lytic (+TPA)”). Where indicated, the cells were also treated with 10 μM of the pan-caspase inhibitor IDN-6556 (“casp-i”). RNA was isolated from cells collected without sorting (“bulk”) or after sorting based on tdTomato expression (tdTomato+ and -). tdTomato mRNA levels were measured by RT-qPCR and normalized to 18S rRNA. mRNA levels are plotted relative to the lytic+casp-i bulk sample. ns = p&gt;0.05, ** = p&lt;0.01, *** = p&lt;0.001, **** = p&lt;0.0001. Two-Way ANOVA followed by Tukey’s post hoc multiple comparisons test. n= 3 for all experiments.
DOI: 10.6084/m9.figshare.31120585.v1
title: S2D Figure

description: S2D Fig. Lentivirally established CMV promoter-driven tdTomato expression does not induce IFN-β in BC-3 cells and does not correlate with IFN-β expression. BC3-CMVp-tdTomato cells were treated with 20 ng/mL TPA for 48 hours to induce the lytic cycle (“lytic (+TPA)”). Where indicated, the cells were also treated with 10 μM of the pan-caspase inhibitor IDN-6556 (“casp-i”). RNA was isolated from cells collected without sorting (“bulk”) or after sorting based on tdTomato expression (tdTomato+ and -). tdTomato mRNA levels were measured by RT-qPCR and normalized to 18S rRNA. mRNA levels are plotted relative to the lytic+casp-i bulk sample. ns = p&gt;0.05, ** = p&lt;0.01, *** = p&lt;0.001, **** = p&lt;0.0001. Two-Way ANOVA followed by Tukey’s post hoc multiple comparisons test. n= 3 for all experiments.
DOI: 10.6084/m9.figshare.31120618
title: S2E Figure

description: S2E Fig. Lentivirally established CMV promoter-driven tdTomato expression does not induce IFN-β in BC-3 cells and does not correlate with IFN-β expression. BC3-CMVp-tdTomato cells were treated with 20 ng/mL TPA for 48 hours to induce the lytic cycle (“lytic (+TPA)”). Where indicated, the cells were also treated with 10 μM of the pan-caspase inhibitor IDN-6556 (“casp-i”). RNA was isolated from cells collected without sorting (“bulk”) or after sorting based on tdTomato expression (tdTomato+ and -). IFN-β mRNA levels were measured by RT-qPCR and normalized to 18S rRNA. mRNA levels are plotted relative to the lytic+casp-i bulk sample. ns = p&gt;0.05, ** = p&lt;0.01, *** = p&lt;0.001, **** = p&lt;0.0001. Two-Way ANOVA followed by Tukey’s post hoc multiple comparisons test. n= 3 for all experiments.
DOI: 10.6084/m9.figshare.31120618.v1
title: S2E Figure

description: S2E Fig. Lentivirally established CMV promoter-driven tdTomato expression does not induce IFN-β in BC-3 cells and does not correlate with IFN-β expression. BC3-CMVp-tdTomato cells were treated with 20 ng/mL TPA for 48 hours to induce the lytic cycle (“lytic (+TPA)”). Where indicated, the cells were also treated with 10 μM of the pan-caspase inhibitor IDN-6556 (“casp-i”). RNA was isolated from cells collected without sorting (“bulk”) or after sorting based on tdTomato expression (tdTomato+ and -). IFN-β mRNA levels were measured by RT-qPCR and normalized to 18S rRNA. mRNA levels are plotted relative to the lytic+casp-i bulk sample. ns = p&gt;0.05, ** = p&lt;0.01, *** = p&lt;0.001, **** = p&lt;0.0001. Two-Way ANOVA followed by Tukey’s post hoc multiple comparisons test. n= 3 for all experiments.
DOI: 10.6084/m9.figshare.31120441
title: S1K Figure

description: S1 Fig. Viral gene expression heterogeneity does not completely explain IFN-β expression. BC3-IFN-βp-tdTomato reporter cells were treated with 20 ng/ml TPA for 48 hours to induce the lytic cycle (“lytic (+TPA)”), 10 μM of the pan-caspase inhibitor IDN-6556 (“casp-i”), and/or a cocktail mix of antibodies against type I IFNs and their receptor (“anti-IFN Abs”) at 1:2000 dilution. Cells from the lytic+casp-i samples were collected both without sorting (“bulk”) and after sorting based on tdTomato expression (tdTomato + and -). RNA was extracted and KSHV ORF52 mRNA levels were measured by RT-qPCR and normalized to 18S rRNA. The fold enrichment of mRNA levels compared to unsorted (“bulk”) samples are plotted in log2 scale. Results in this figure were obtained from the same samples used in Fig 1 and are thus directly comparable to IFN-β enrichment shown in those Figure. ns = p&gt;0.05, ** = p&lt;0.01. One-Way ANOVA followed by Tukey’s post hoc multiple comparisons test. n≥ 4 for all experiments.
DOI: 10.6084/m9.figshare.31120441.v1
title: S1K Figure

description: S1 Fig. Viral gene expression heterogeneity does not completely explain IFN-β expression. BC3-IFN-βp-tdTomato reporter cells were treated with 20 ng/ml TPA for 48 hours to induce the lytic cycle (“lytic (+TPA)”), 10 μM of the pan-caspase inhibitor IDN-6556 (“casp-i”), and/or a cocktail mix of antibodies against type I IFNs and their receptor (“anti-IFN Abs”) at 1:2000 dilution. Cells from the lytic+casp-i samples were collected both without sorting (“bulk”) and after sorting based on tdTomato expression (tdTomato + and -). RNA was extracted and KSHV ORF52 mRNA levels were measured by RT-qPCR and normalized to 18S rRNA. The fold enrichment of mRNA levels compared to unsorted (“bulk”) samples are plotted in log2 scale. Results in this figure were obtained from the same samples used in Fig 1 and are thus directly comparable to IFN-β enrichment shown in those Figure. ns = p&gt;0.05, ** = p&lt;0.01. One-Way ANOVA followed by Tukey’s post hoc multiple comparisons test. n≥ 4 for all experiments.