cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.17615/yjtq-b747
title: Non-invasive 4D transcranial contrast-enhanced functional ultrasound imaging in mice with Alzheimer’s Disease during vibrotactile stimulation (Part 5)

description: Functional ultrasound (fUS) is an imaging technique that can measure changes in cerebral blood flow (CBF). However, transcranial ultrasound imaging is challenging due to the aberration and reverberation of sound due to the skull. Microbubble contrast-enhancement can overcome sensitivity limitations. Here, we propose a completely non-invasive 4D contrast-enhanced fUS approach to image brain hemodynamics at high spatial (200 um) and temporal resolutions (20 ms), providing a method to better study the localized changes in brain activity. The capabilities of this technique are demonstrated in Alzheimer's Disease (AD), a neurodegenerative disorder that is one of the leading causes of disability and death. Compared to conventional neuroimaging tools that are used for diagnosis and monitoring the proposed technique has higher spatial and temporal resolution. To demonstrate the capabilities of this contrast-enhanced fUS technique to transcranially image volumetric cerebral hemodynamics, it was applied to five wild-type (WT) mice and five mice with AD at rest (baseline) during vibrotactile stimulation of the front or hind paw. WT mice, on average, experienced 10.7-23.9 % higher mean CBF for each stimulation case but 17.0-20.3 % lower mean connectivity than mice with AD. Five specific regions were highlighted in this comparison that are known to be affected by AD. These were the entorhinal cortex, hippocampus, thalamus, parietal cortex, and frontal cortex. AD mice exhibited hyper-connectivity in the hippocampus, one of the first regions affected by AD in this mouse model, and lower CBF in all five regions. Both the CBF and connectivity results from this technique agree with published gold-standard fMRI AD findings that account for the age of the animals. In summary, it is demonstrated that 4D fUS can non-invasively detect and monitor changes in cerebral hemodynamics associated with AD with high temporal resolution, enabling longitudinal functional assessments of these effects in rodent AD models.
DOI: 10.17615/apnw-3049
title: Non-invasive 4D transcranial contrast-enhanced functional ultrasound imaging in mice with Alzheimer’s Disease during vibrotactile stimulation (Part 6)

description: Functional ultrasound (fUS) is an imaging technique that can measure changes in cerebral blood flow (CBF). However, transcranial ultrasound imaging is challenging due to the aberration and reverberation of sound due to the skull. Microbubble contrast-enhancement can overcome sensitivity limitations. Here, we propose a completely non-invasive 4D contrast-enhanced fUS approach to image brain hemodynamics at high spatial (200 um) and temporal resolutions (20 ms), providing a method to better study the localized changes in brain activity. The capabilities of this technique are demonstrated in Alzheimer's Disease (AD), a neurodegenerative disorder that is one of the leading causes of disability and death. Compared to conventional neuroimaging tools that are used for diagnosis and monitoring the proposed technique has higher spatial and temporal resolution. To demonstrate the capabilities of this contrast-enhanced fUS technique to transcranially image volumetric cerebral hemodynamics, it was applied to five wild-type (WT) mice and five mice with AD at rest (baseline) during vibrotactile stimulation of the front or hind paw. WT mice, on average, experienced 10.7-23.9 % higher mean CBF for each stimulation case but 17.0-20.3 % lower mean connectivity than mice with AD. Five specific regions were highlighted in this comparison that are known to be affected by AD. These were the entorhinal cortex, hippocampus, thalamus, parietal cortex, and frontal cortex. AD mice exhibited hyper-connectivity in the hippocampus, one of the first regions affected by AD in this mouse model, and lower CBF in all five regions. Both the CBF and connectivity results from this technique agree with published gold-standard fMRI AD findings that account for the age of the animals. In summary, it is demonstrated that 4D fUS can non-invasively detect and monitor changes in cerebral hemodynamics associated with AD with high temporal resolution, enabling longitudinal functional assessments of these effects in rodent AD models.
DOI: 10.17615/t9x0-xv54
title: Non-invasive 4D transcranial contrast-enhanced functional ultrasound imaging in mice with Alzheimer’s Disease during vibrotactile stimulation (Part 7)

description: Functional ultrasound (fUS) is an imaging technique that can measure changes in cerebral blood flow (CBF). However, transcranial ultrasound imaging is challenging due to the aberration and reverberation of sound due to the skull. Microbubble contrast-enhancement can overcome sensitivity limitations. Here, we propose a completely non-invasive 4D contrast-enhanced fUS approach to image brain hemodynamics at high spatial (200 um) and temporal resolutions (20 ms), providing a method to better study the localized changes in brain activity. The capabilities of this technique are demonstrated in Alzheimer's Disease (AD), a neurodegenerative disorder that is one of the leading causes of disability and death. Compared to conventional neuroimaging tools that are used for diagnosis and monitoring the proposed technique has higher spatial and temporal resolution. To demonstrate the capabilities of this contrast-enhanced fUS technique to transcranially image volumetric cerebral hemodynamics, it was applied to five wild-type (WT) mice and five mice with AD at rest (baseline) during vibrotactile stimulation of the front or hind paw. WT mice, on average, experienced 10.7-23.9 % higher mean CBF for each stimulation case but 17.0-20.3 % lower mean connectivity than mice with AD. Five specific regions were highlighted in this comparison that are known to be affected by AD. These were the entorhinal cortex, hippocampus, thalamus, parietal cortex, and frontal cortex. AD mice exhibited hyper-connectivity in the hippocampus, one of the first regions affected by AD in this mouse model, and lower CBF in all five regions. Both the CBF and connectivity results from this technique agree with published gold-standard fMRI AD findings that account for the age of the animals. In summary, it is demonstrated that 4D fUS can non-invasively detect and monitor changes in cerebral hemodynamics associated with AD with high temporal resolution, enabling longitudinal functional assessments of these effects in rodent AD models.
DOI: 10.17615/e792-ej81
title: Non-invasive 4D transcranial contrast-enhanced functional ultrasound imaging in mice with Alzheimer’s Disease during vibrotactile stimulation (Part 8)

description: Functional ultrasound (fUS) is an imaging technique that can measure changes in cerebral blood flow (CBF). However, transcranial ultrasound imaging is challenging due to the aberration and reverberation of sound due to the skull. Microbubble contrast-enhancement can overcome sensitivity limitations. Here, we propose a completely non-invasive 4D contrast-enhanced fUS approach to image brain hemodynamics at high spatial (200 um) and temporal resolutions (20 ms), providing a method to better study the localized changes in brain activity. The capabilities of this technique are demonstrated in Alzheimer's Disease (AD), a neurodegenerative disorder that is one of the leading causes of disability and death. Compared to conventional neuroimaging tools that are used for diagnosis and monitoring the proposed technique has higher spatial and temporal resolution. To demonstrate the capabilities of this contrast-enhanced fUS technique to transcranially image volumetric cerebral hemodynamics, it was applied to five wild-type (WT) mice and five mice with AD at rest (baseline) during vibrotactile stimulation of the front or hind paw. WT mice, on average, experienced 10.7-23.9 % higher mean CBF for each stimulation case but 17.0-20.3 % lower mean connectivity than mice with AD. Five specific regions were highlighted in this comparison that are known to be affected by AD. These were the entorhinal cortex, hippocampus, thalamus, parietal cortex, and frontal cortex. AD mice exhibited hyper-connectivity in the hippocampus, one of the first regions affected by AD in this mouse model, and lower CBF in all five regions. Both the CBF and connectivity results from this technique agree with published gold-standard fMRI AD findings that account for the age of the animals. In summary, it is demonstrated that 4D fUS can non-invasively detect and monitor changes in cerebral hemodynamics associated with AD with high temporal resolution, enabling longitudinal functional assessments of these effects in rodent AD models.
DOI: 10.15468/dl.pqjxv6
title: Occurrence Download

description: A dataset containing 358 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Dentex tumifrons (Temminck & Schlegel, 1843)",
 "Geometry POLYGON((170 20, 170 50, 120 50, 120 20, 170 20))",
 "HasCoordinate is true"
 ]
}

 The dataset includes 358 records from 31 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0020170-240626123714530/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.7x6du2
title: Occurrence Download

description: A dataset containing 1187242 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Geometry POLYGON((-20.05918 41.73836,47.49866 41.73836,47.49866 68.74993,-20.05918 68.74993,-20.05918 41.73836))",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 "TaxonKey is Capreolus capreolus (Linnaeus, 1758)"
 ]
}

 The dataset includes 1187242 records from 4031 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0020164-240626123714530/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.qv272g
title: Occurrence Download

description: A dataset containing 2840 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Arabis soyeri Reut. & A.Huet.)",
 "Geometry POLYGON((-9.36035 44.71551,-10.59082 42.81152,-11.82129 36.80928,-7.69043 36.17336,-3.38379 35.88905,3.12012 38.13456,9.18457 38.20366,11.7334 37.16032,12.78809 34.74161,17.09473 33.79741, 23.15918 34.23451,30.10254 32.62087,33.2666 32.99024,35.72754 35.03,33.00293 35.53223,28.69629 35.17381,28.34473 36.31513,25.7959 37.50973,24.91699 39.90974,28.78418 40.6473,30.71777 41.17865,36.87012 45.213,38.18848 46.98025,38.71582 47.7541,39.94629 47.93107,40.20996 49.61071,37.0459 50.34546,35.72754 50.40152,33.79395 52.26816,31.68457 51.94426,31.4209 53.27835,32.56348 53.43572,30.98145 54.77535,30.89355 55.52863,28.43262 56.02295,27.20215 57.65716,27.37793 58.30949,27.90527 59.17593,29.66309 59.88894,27.6416 60.58697,31.50879 62.75473,28.78418 69.83962,30.89355 70.28912,29.22363 71.55274,21.75293 71.30079,14.28223 70.14036,11.38184 67.47492,4.87793 63.66576,-5.53711 71.52491,-10.63477 71.69129,-21.5332 67.74276,-28.56445 65.36684,-24.3457 61.35461,-9.36035 44.71551))",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "Year is greater than or equal to 1980",
 "Year is less than or equal to 2021"
 ]
}

 The dataset includes 2840 records from 41 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0231151-210914110416597/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.j4keh7
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Bodonophyceae",
 "HasCoordinate is true",
 "Country is one of (Norway)",
 "HasGeospatialIssue is false",
 "Year is greater than 2009"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0231157-210914110416597/datasets/export for details.
DOI: 10.15468/dl.wtq4p2
title: Occurrence Download

description: A dataset containing 178 species occurrences available in GBIF matching the query:
{
 "and" : [
 "HasCoordinate is true",
 "TaxonKey is Calotriton arnoldi Carranza & Amat, 2005"
 ]
}

 The dataset includes 178 records from 7 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0380186-210914110416597/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.f8ubtq
title: Occurrence Download

description: A dataset containing 26485 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Galeopsis ladanum L.",
 "HasGeospatialIssue is false",
 "HasCoordinate is true",
 "OccurrenceStatus is Present"
 ]
}

 The dataset includes 26485 records from 351 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0116593-230224095556074/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.rv93xh
title: Occurrence Download

description: A dataset containing 735 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Choanoflagellatea",
 "HasCoordinate is true",
 "Country is one of (Norway)",
 "HasGeospatialIssue is false",
 "Year is greater than 2009"
 ]
}

 The dataset includes 735 records from 4 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0231172-210914110416597/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.jpjwp4
title: Occurrence Download

description: A dataset containing 56 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Plehniidae",
 "Continent is one of (North America, South America)"
 ]
}

 The dataset includes 56 records from 5 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0017959-230810091245214/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.heruht
title: Occurrence Download

description: A dataset containing 5441 species occurrences available in GBIF matching the query:
{
 "and" : [
 {
 "or" : [
 "PublishingCountry is Colombia",
 {
 "and" : [
 "Country is Colombia",
 {
 "not" : {
 "Issue" : [
 "is Country coordinate mismatch"
 ]
 }
 }
 ]
 }
 ]
 },
 {
 "and" : [
 "Locality is one of (finca el placer (acceso privado))",
 "StateProvince is one of (caldas)"
 ]
 }
 ]
}

 The dataset includes 5441 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0299548-210914110416597/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.bcdhkz
title: Occurrence Download

description: A dataset containing 366 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Astragalus pinetorum Boiss."
 ]
}

 The dataset includes 366 records from 41 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0017970-230810091245214/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.rxm82m
title: Occurrence Download

description: A dataset containing 1379 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Sceloporus pyrocephalus Cope, 1864"
 ]
}

 The dataset includes 1379 records from 36 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0284497-210914110416597/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.npmdqy
title: Occurrence Download

description: A dataset containing 31337 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Cerianthus lloydii Gosse, 1859"
 ]
}

 The dataset includes 31337 records from 87 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0116573-230224095556074/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.yjkjsd
title: Occurrence Download

description: A dataset listing the 2 species recorded in GBIF matching the query:
{
 "and" : [
 "Geometry POLYGON((-130.7373 31.28906,-102.7002 31.28906,-102.7002 50.18555,-130.7373 50.18555,-130.7373 31.28906))",
 "TaxonKey is Sarracenia purpurea L."
 ]
}

 The dataset's 2 records were derived from 10 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0284541-210914110416597/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.tkpmnt
title: Occurrence Download

description: A dataset containing 826 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Euphrasia bottnica Kihlm.",
 "HasGeospatialIssue is false",
 "HasCoordinate is true",
 "OccurrenceStatus is Present"
 ]
}

 The dataset includes 826 records from 20 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0116583-230224095556074/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.6u5pa2
title: Occurrence Download

description: A dataset containing 15 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Ischnocnema spanios (Heyer, 1985)"
 ]
}

 The dataset includes 15 records from 3 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0299575-210914110416597/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.nge22a
title: Occurrence Download

description: A dataset containing 2717 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Eucobresia diaphana (Draparnaud, 1805)"
 ]
}

 The dataset includes 2717 records from 52 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0116611-230224095556074/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.tzjnhg
title: Occurrence Download

description: A dataset containing 22 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Pristimantis aureolineatus (Guayasamin, Ron, Cisneros-Heredia, Lamar & McCracken, 2006)"
 ]
}

 The dataset includes 22 records from 5 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0299559-210914110416597/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.w9dpe4
title: Occurrence Download

description: A dataset containing 33 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Maxillaria tonduzii (Schltr.) Ames & Correll"
 ]
}

 The dataset includes 33 records from 15 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0116666-230224095556074/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.ex9g9t
title: Occurrence Download

description: A dataset containing 19572 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Pseudoturritis turrita (L.) Al-Shehbaz)",
 "Geometry POLYGON((-9.36035 44.71551,-10.59082 42.81152,-11.82129 36.80928,-7.69043 36.17336,-3.38379 35.88905,3.12012 38.13456,9.18457 38.20366,11.7334 37.16032,12.78809 34.74161,17.09473 33.79741, 23.15918 34.23451,30.10254 32.62087,33.2666 32.99024,35.72754 35.03,33.00293 35.53223,28.69629 35.17381,28.34473 36.31513,25.7959 37.50973,24.91699 39.90974,28.78418 40.6473,30.71777 41.17865,36.87012 45.213,38.18848 46.98025,38.71582 47.7541,39.94629 47.93107,40.20996 49.61071,37.0459 50.34546,35.72754 50.40152,33.79395 52.26816,31.68457 51.94426,31.4209 53.27835,32.56348 53.43572,30.98145 54.77535,30.89355 55.52863,28.43262 56.02295,27.20215 57.65716,27.37793 58.30949,27.90527 59.17593,29.66309 59.88894,27.6416 60.58697,31.50879 62.75473,28.78418 69.83962,30.89355 70.28912,29.22363 71.55274,21.75293 71.30079,14.28223 70.14036,11.38184 67.47492,4.87793 63.66576,-5.53711 71.52491,-10.63477 71.69129,-21.5332 67.74276,-28.56445 65.36684,-24.3457 61.35461,-9.36035 44.71551))",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "Year is greater than or equal to 1980",
 "Year is less than or equal to 2021"
 ]
}

 The dataset includes 19572 records from 137 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0231154-210914110416597/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.25qc83
title: Occurrence Download

description: A dataset containing 39 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Astragalus decurrens Boiss."
 ]
}

 The dataset includes 39 records from 13 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0017971-230810091245214/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.yxx64x
title: Occurrence Download

description: A dataset containing 262 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Rena dissecta (Cope, 1896)"
 ]
}

 The dataset includes 262 records from 31 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0284498-210914110416597/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.vq9syu
title: Occurrence Download

description: A dataset containing 55081 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Saxifraga oppositifolia L.",
 "HasGeospatialIssue is false",
 "HasCoordinate is true",
 "OccurrenceStatus is Present"
 ]
}

 The dataset includes 55081 records from 327 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0116622-230224095556074/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.g4449a
title: Occurrence Download

description: A dataset containing 1632 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Chrysophyceae",
 "HasCoordinate is true",
 "Country is one of (Norway)",
 "HasGeospatialIssue is false",
 "Year is greater than 2009"
 ]
}

 The dataset includes 1632 records from 8 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0231166-210914110416597/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.4e9kfb
title: Occurrence Download

description: A dataset containing 38419 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Micranthes stellaris (L.) Galasso, Banfi & Soldano",
 "HasGeospatialIssue is false",
 "HasCoordinate is true",
 "OccurrenceStatus is Present"
 ]
}

 The dataset includes 38419 records from 344 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0116616-230224095556074/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.