cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.21981197.v1
title: Extracellular lipids of Candida albicans biofilm induce lipid droplet formation and decreased response to a topoisomerase I inhibitor in dysplastic and neoplastic oral cells

description: Abstract Objective Some microorganisms, i.e., Candida albicans, have been associated with cancer onset and development, although whether the fungus promotes cancer or whether cancer facilitates the growth of C. albicans is unclear. In this context, microbial-derived molecules can modulate the growth and resistance of cancer cells. This study isolated extracellular lipids (ECL) from a 36-h Candida albicans biofilm incubated with oral dysplastic (DOK) and neoplastic (SCC 25) cells, which were further challenged with the topoisomerase I inhibitor camptothecin (CPT), a lipophilic anti-tumoral molecule. Methodology ECL were extracted from a 36-h Candida albicans biofilm with the methanol/chloroform precipitation method and identified with Nuclear Magnetic Resonance (1H-NMR). The MTT tetrazolium assay measured ECL cytotoxicity in DOK and SCC 25 cells, alamarBlue™ assessed cell metabolism, flow cytometry measured cell cycle, and confocal microscopy determined intracellular features. Results Three major classes of ECL of C. albicans biofilm were found: phosphatidylinositol (PI), phosphatidylcholine (PC), and phosphatidylglycerol (PG). The ECL of C. albicans biofilm had no cytotoxic effect on neither cell after 24 hours, with a tendency to disturb the SCC 25 cell cycle profile (without statistical significance). The ECL-induced intracellular lipid droplet (LD) formation on both cell lines after 72 hours. In this context, ECL enhanced cell metabolism, decreased the response to CPT, and modified intracellular drug distribution. Conclusion The ECL (PI, PC, and PG) of 36-h Candida albicans biofilm directly interacts with dysplastic and neoplastic oral cells, highlighting the relevance of better understanding C. albicans biofilm signaling in the microenvironment of tumor cells.
DOI: 10.6084/m9.figshare.21981229
title: C5aR antagonist inhibits LPS-induced inflammation in human gingival fibroblasts via NF-κB and MAPK signaling pathways

description: Abstract Objective Abnormal complement activation is associated with periodontitis. W54011 is a novel non-peptide C5aR antagonist (C5aRA) that exhibits favorable anti-inflammatory effects in various inflammatory models. However, whether W54011 inhibits periodontitis has not yet been fully elucidated. To address this, we have investigated the probable anti-inflammatory mechanism of W54011 in LPS-treated inflammation in human gingival fibroblasts (HGFs). Methodology HGFs were isolated from healthy gingival tissue samples using the tissue block method and were identified with immunofluorescence staining. The CCK8 assay and reverse transcription-PCR (RT-PCR) were used to select the optimal induction conditions for Lipopolysaccharide (LPS) and C5aRA (according to supplementary data S1, S2 and S3). The levels of inflammatory cytokines, C5aR, and the activation of NF-κB/MAPK signaling pathways were determined by RT-quantitative PCR (RT-qPCR) and Western blotting. Results Immunofluorescence results showed that vimentin and FSP-1 were positive in HGFs and Keratin was negative in HGFs. Immunofluorescence staining demonstrated that C5aRA inhibited LPS-stimulated nuclear translocation of p-p65. RT-qPCR and Western blotting showed that C5aRA reduced the expression of IL-1β, IL-6, TNF-α, C5aR, p-p65, p-IκBα, p-JNK, p-c-JUN, and TLR4 in LPS-induced HGFs. Conclusion These findings suggested that C5aRA attenuated the release of inflammatory cytokines in LPS-induced HGFs by blocking the activation of the NF-κB and MAPK signaling pathways.
DOI: 10.6084/m9.figshare.21981229.v1
title: C5aR antagonist inhibits LPS-induced inflammation in human gingival fibroblasts via NF-κB and MAPK signaling pathways

description: Abstract Objective Abnormal complement activation is associated with periodontitis. W54011 is a novel non-peptide C5aR antagonist (C5aRA) that exhibits favorable anti-inflammatory effects in various inflammatory models. However, whether W54011 inhibits periodontitis has not yet been fully elucidated. To address this, we have investigated the probable anti-inflammatory mechanism of W54011 in LPS-treated inflammation in human gingival fibroblasts (HGFs). Methodology HGFs were isolated from healthy gingival tissue samples using the tissue block method and were identified with immunofluorescence staining. The CCK8 assay and reverse transcription-PCR (RT-PCR) were used to select the optimal induction conditions for Lipopolysaccharide (LPS) and C5aRA (according to supplementary data S1, S2 and S3). The levels of inflammatory cytokines, C5aR, and the activation of NF-κB/MAPK signaling pathways were determined by RT-quantitative PCR (RT-qPCR) and Western blotting. Results Immunofluorescence results showed that vimentin and FSP-1 were positive in HGFs and Keratin was negative in HGFs. Immunofluorescence staining demonstrated that C5aRA inhibited LPS-stimulated nuclear translocation of p-p65. RT-qPCR and Western blotting showed that C5aRA reduced the expression of IL-1β, IL-6, TNF-α, C5aR, p-p65, p-IκBα, p-JNK, p-c-JUN, and TLR4 in LPS-induced HGFs. Conclusion These findings suggested that C5aRA attenuated the release of inflammatory cytokines in LPS-induced HGFs by blocking the activation of the NF-κB and MAPK signaling pathways.
DOI: 10.5517/ccdc.csd.cc28zc8x
title: CCDC 2114549: Experimental Crystal Structure Determination

description: Related Article: Hoeun Seong, Yongsung Jo, Vladimir Efremov, Yujin Kim, Sojung Park, Sang Myeong Han, Kiyoung Chang, Jiwoo Park, Woojun Choi, Wooyul Kim, Chang Hyuck Choi, Jong Suk Yoo, Dongil Lee|2023|J.Am.Chem.Soc.|145|2152|doi:10.1021/jacs.2c09170
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2b5qdn
title: CCDC 2150451: Experimental Crystal Structure Determination

description: Related Article: Maxime Ribéraud, Karine Porte, Arnaud Chevalier, Léa Madegard, Aurélie Rachet, Agnès Delaunay-Moisan, Florian Vinchon, Pierre Thuéry, Giovanni Chiappetta, Pier Alexandre Champagne, Grégory Pieters, Davide Audisio, Frédéric Taran|2023|J.Am.Chem.Soc.|145|2219|doi:10.1021/jacs.2c09865
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2b5qfp
title: CCDC 2150452: Experimental Crystal Structure Determination

description: Related Article: Maxime Ribéraud, Karine Porte, Arnaud Chevalier, Léa Madegard, Aurélie Rachet, Agnès Delaunay-Moisan, Florian Vinchon, Pierre Thuéry, Giovanni Chiappetta, Pier Alexandre Champagne, Grégory Pieters, Davide Audisio, Frédéric Taran|2023|J.Am.Chem.Soc.|145|2219|doi:10.1021/jacs.2c09865
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2b5qgq
title: CCDC 2150453: Experimental Crystal Structure Determination

description: Related Article: Maxime Ribéraud, Karine Porte, Arnaud Chevalier, Léa Madegard, Aurélie Rachet, Agnès Delaunay-Moisan, Florian Vinchon, Pierre Thuéry, Giovanni Chiappetta, Pier Alexandre Champagne, Grégory Pieters, Davide Audisio, Frédéric Taran|2023|J.Am.Chem.Soc.|145|2219|doi:10.1021/jacs.2c09865
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2b5qhr
title: CCDC 2150454: Experimental Crystal Structure Determination

description: Related Article: Maxime Ribéraud, Karine Porte, Arnaud Chevalier, Léa Madegard, Aurélie Rachet, Agnès Delaunay-Moisan, Florian Vinchon, Pierre Thuéry, Giovanni Chiappetta, Pier Alexandre Champagne, Grégory Pieters, Davide Audisio, Frédéric Taran|2023|J.Am.Chem.Soc.|145|2219|doi:10.1021/jacs.2c09865
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2b5qjs
title: CCDC 2150455: Experimental Crystal Structure Determination

description: Related Article: Maxime Ribéraud, Karine Porte, Arnaud Chevalier, Léa Madegard, Aurélie Rachet, Agnès Delaunay-Moisan, Florian Vinchon, Pierre Thuéry, Giovanni Chiappetta, Pier Alexandre Champagne, Grégory Pieters, Davide Audisio, Frédéric Taran|2023|J.Am.Chem.Soc.|145|2219|doi:10.1021/jacs.2c09865
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2b5qkt
title: CCDC 2150456: Experimental Crystal Structure Determination

description: Related Article: Maxime Ribéraud, Karine Porte, Arnaud Chevalier, Léa Madegard, Aurélie Rachet, Agnès Delaunay-Moisan, Florian Vinchon, Pierre Thuéry, Giovanni Chiappetta, Pier Alexandre Champagne, Grégory Pieters, Davide Audisio, Frédéric Taran|2023|J.Am.Chem.Soc.|145|2219|doi:10.1021/jacs.2c09865
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2b5qlv
title: CCDC 2150457: Experimental Crystal Structure Determination

description: Related Article: Maxime Ribéraud, Karine Porte, Arnaud Chevalier, Léa Madegard, Aurélie Rachet, Agnès Delaunay-Moisan, Florian Vinchon, Pierre Thuéry, Giovanni Chiappetta, Pier Alexandre Champagne, Grégory Pieters, Davide Audisio, Frédéric Taran|2023|J.Am.Chem.Soc.|145|2219|doi:10.1021/jacs.2c09865
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2bbdsw
title: CCDC 2154958: Experimental Crystal Structure Determination

description: Related Article: Huilin Huang, Xu Jing, Jiangtao Deng, Changgong Meng, Chunying Duan|2023|J.Am.Chem.Soc.|145|2170|doi:10.1021/jacs.2c09348
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2bbdtx
title: CCDC 2154959: Experimental Crystal Structure Determination

description: Related Article: Huilin Huang, Xu Jing, Jiangtao Deng, Changgong Meng, Chunying Duan|2023|J.Am.Chem.Soc.|145|2170|doi:10.1021/jacs.2c09348
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2bbdvy
title: CCDC 2154960: Experimental Crystal Structure Determination

description: Related Article: Huilin Huang, Xu Jing, Jiangtao Deng, Changgong Meng, Chunying Duan|2023|J.Am.Chem.Soc.|145|2170|doi:10.1021/jacs.2c09348
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2bvrml
title: CCDC 2170670: Experimental Crystal Structure Determination

description: Related Article: J.-Z. Liao, Y. Jiang, F.-F. He, L.-L. Jiang, X.-M. Zhu, H. Ke|2023|Materials Today Chemistry|27|101324|doi:10.1016/j.mtchem.2022.101324
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc27nbqz
title: CCDC 2075131: Experimental Crystal Structure Determination

description: Related Article: R. Huo, C. Wang, F. Xu, Y.-H. Xing, Y.-F. Wang, F.-Y. Bai|2023|Materials Today Chemistry|27|101292|doi:10.1016/j.mtchem.2022.101292
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2c46wm
title: CCDC 2178800: Experimental Crystal Structure Determination

description: Related Article: Daniel Pecorari, Emanuele Giuliani, Andrea Mazzanti, Stefano Stagni, Valentina Fiorini, Giulia Vigarani, Francesco Zinna, Gennaro Pescitelli, Michele Mancinelli|2023|J.Org.Chem.|88|871|doi:10.1021/acs.joc.2c02209
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2c448y
title: CCDC 2178719: Experimental Crystal Structure Determination

description: Related Article: Hoeun Seong, Yongsung Jo, Vladimir Efremov, Yujin Kim, Sojung Park, Sang Myeong Han, Kiyoung Chang, Jiwoo Park, Woojun Choi, Wooyul Kim, Chang Hyuck Choi, Jong Suk Yoo, Dongil Lee|2023|J.Am.Chem.Soc.|145|2152|doi:10.1021/jacs.2c09170
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.6084/m9.figshare.22010279
title: Drastic changes before the 2011 Tohoku earthquake, revealed by exploratory data analysis

description: Predicting earthquakes is of the utmost importance, especially to those countries of high risk, and although much effort has been made, it has yet to be realised. Nevertheless, there is a paucity of statistical approaches in seismic studies to the extent that an old theory is believed without verification. Seismic records of time and magnitude in Japan were analysed by exploratory data analysis (EDA). EDA is a parametric statistical approach based on the characteristics of data and is suitable for data-driven investigations. The distribution style of each dataset was determined, and the important parameters were found. This enabled us to identify and evaluate the anomalies in the data. Before the huge 2011 Tohoku earthquake, swarm earthquakes occurred before the main earthquake at improbable frequencies. The frequency and magnitude of all earthquakes increased. Both changes made larger earthquakes more likely to occur: even an M9 earthquake was expected every two years. From these simple measurements, the EDA succeeded in extracting useful information. Detecting and evaluating anomalies using this approach for every set of data would lead to a more accurate prediction of earthquakes.
DOI: 10.6084/m9.figshare.22010282
title: Raw data used in WB, IF, and qPCR quantifications and statistical analysis.xlsx

description: Raw data used in WB, IF, and qPCR quantifications and statistical analysis
DOI: 10.6084/m9.figshare.22010282.v1
title: Raw data used in WB, IF, and qPCR quantifications and statistical analysis.xlsx

description: Raw data used in WB, IF, and qPCR quantifications and statistical analysis
DOI: 10.6084/m9.figshare.22010306
title: Complete Raw Data

description: Complete raw data
DOI: 10.5517/ccdc.csd.cc2cwhd5
title: CCDC 2201167: Experimental Crystal Structure Determination

description: Related Article: Tomasz Charytanowicz, Barbara Sieklucka, Szymon Chorazy|2023|Inorg.Chem.|62|1611|doi:10.1021/acs.inorgchem.2c03885
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2cwhf6
title: CCDC 2201168: Experimental Crystal Structure Determination

description: Related Article: Tomasz Charytanowicz, Barbara Sieklucka, Szymon Chorazy|2023|Inorg.Chem.|62|1611|doi:10.1021/acs.inorgchem.2c03885
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2d0y7m
title: CCDC 2205440: Experimental Crystal Structure Determination

description: Related Article: Bing-Xian Li, Yan Shu, Sheng-Qi Zhang, Rui-Dang Yang, Lin-Lin Yao, Jia-Qi Liu, Shuai-Xing Liu, Jia-Peng Wang, Le Cai|2023|Fitoterapia|165|105429|doi:10.1016/j.fitote.2023.105429
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2d3770
title: CCDC 2207641: Experimental Crystal Structure Determination

description: Related Article: Zeng-Xi Yang, Xue-Wei Liang, Dunmin Lin, Qiaoji Zheng, Yu Huo|2023|Inorg.Chem.|62|1466|doi:10.1021/acs.inorgchem.2c03561
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2d3781
title: CCDC 2207642: Experimental Crystal Structure Determination

description: Related Article: Zeng-Xi Yang, Xue-Wei Liang, Dunmin Lin, Qiaoji Zheng, Yu Huo|2023|Inorg.Chem.|62|1466|doi:10.1021/acs.inorgchem.2c03561
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2d3792
title: CCDC 2207643: Experimental Crystal Structure Determination

description: Related Article: Zeng-Xi Yang, Xue-Wei Liang, Dunmin Lin, Qiaoji Zheng, Yu Huo|2023|Inorg.Chem.|62|1466|doi:10.1021/acs.inorgchem.2c03561
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2d37b3
title: CCDC 2207644: Experimental Crystal Structure Determination

description: Related Article: Zeng-Xi Yang, Xue-Wei Liang, Dunmin Lin, Qiaoji Zheng, Yu Huo|2023|Inorg.Chem.|62|1466|doi:10.1021/acs.inorgchem.2c03561
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2ddz3x
title: CCDC 2216999: Experimental Crystal Structure Determination

description: Related Article: Yun-Hai Sun, Cheng-Jing Li, Ji-Ming Xi, Zhong-Lin Wei, Wei-Wei Liao|2022|Org.Chem.Front.|10|705|doi:10.1039/D2QO01821G
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2ddxh7
title: CCDC 2216949: Experimental Crystal Structure Determination

description: Related Article: Shahnawaz Khan, Monish Arbaz Ansari, Maya Shankar Singh|2023|Org.Lett.|25|642|doi:10.1021/acs.orglett.2c04223
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.34740/kaggle/dsv/4945068
title: Elon Musk Tweets
DOI: 10.34740/kaggle/dsv/4945084
title: AutoXGB
DOI: 10.6084/m9.figshare.22010315
title: Closely-spaced OSL dating reveals early Holocene dust activity variation in the southern Tibetan Plateau as response to solar irradiance

description: It contains grain size and magnetic susceptibility