cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.7270/q25143br
title: BindingDB Entry 50018011: Design, synthesis and biological evaluations of novel farnesoid X receptor (FXR) agonists.

description: Small molecule binding data for protein Bile acid receptor, Uniprot Q96RI1
DOI: 10.7270/q28s4v1b
title: BindingDB Entry 50018010: Design, synthesis and biological evaluation of pteridine-7(8H)-one derivatives as potent and selective CDK4/6 inhibitors.

description: Small molecule binding data for protein CDK-activating kinase assembly factor MAT1/Cyclin-H/Cyclin-dependent kinase 7, Cyclin-T1/Cyclin-dependent kinase 9, Cyclin-dependent kinase 2/G1/S-specific cyclin-E1, Cyclin-dependent kinase 4/G1/S-specific cyclin-D1, and Cyclin-dependent kinase 6/G1/S-specific cyclin-D1, Uniprot O60563, P11802, P24385, P24864, P24941, P50613, P50750, P51946, P51948, and Q00534
DOI: 10.7270/q2dj5krn
title: BindingDB Entry 50018009: Discovery of a potent M

description: Small molecule binding data for protein Muscarinic acetylcholine receptor M1, Muscarinic acetylcholine receptor M2, Muscarinic acetylcholine receptor M3, Muscarinic acetylcholine receptor M4, and Muscarinic acetylcholine receptor M5, Uniprot P08172, P08173, P08482, P08911, P08912, P11229, and P20309
DOI: 10.7270/q2j96bgc
title: BindingDB Entry 50018007: A simplified analog of debromoaplysiatoxin lacking the B-ring of spiroketal moiety retains protein kinase C-binding and antiproliferative activities.

description: Small molecule binding data for protein Protein kinase C alpha type and Protein kinase C delta type, Uniprot P17252 and Q05655
DOI: 10.7270/q2nz8crm
title: BindingDB Entry 50018006: Discovery of Selenium-Containing STING Agonists as Orally Available Antitumor Agents.

description: Small molecule binding data for protein Stimulator of interferon genes protein, Uniprot Q3TBT3 and Q86WV6
DOI: 10.7270/q2sq94gb
title: BindingDB Entry 50018004: A closer look at N

description: Small molecule binding data for protein 1-acyl-sn-glycerol-3-phosphate acyltransferase beta, 5-hydroxytryptamine receptor 1A, 5-hydroxytryptamine receptor 2A, 5-hydroxytryptamine receptor 6, 5-hydroxytryptamine receptor 7, Cyclic GMP-AMP synthase, Cytochrome b-245 heavy chain, D(2) dopamine receptor, Equilibrative nucleoside transporter 1, Equilibrative nucleoside transporter 2, Free fatty acid receptor 1, Inosine-5'-monophosphate dehydrogenase 2, NADPH oxidase 1, NADPH oxidase 3, NADPH oxidase 4, and NADPH oxidase 5, Uniprot O14842, O15120, P04839, P08908, P12268, P14416, P28223, P34969, P50406, Q14542, Q8N884, Q96PH1, Q99808, Q9HBY0, Q9NPH5, and Q9Y5S8
DOI: 10.7270/q2xg9w74
title: BindingDB Entry 50018003: Recent advances in combretastatin A-4 codrugs for cancer therapy.

description: Small molecule binding data for protein Estrogen receptor and Estrogen receptor beta, Uniprot P03372 and Q92731
DOI: 10.7270/q2280cqz
title: BindingDB Entry 50018000: Discovery of the First Selective IDO2 Inhibitor As Novel Immunotherapeutic Avenues for Rheumatoid Arthritis.

description: Small molecule binding data for protein Indoleamine 2,3-dioxygenase 1, Indoleamine 2,3-dioxygenase 2, and Tryptophan 2,3-dioxygenase, Uniprot P14902, P48775, and Q6ZQW0
DOI: 10.7270/q26114fp
title: BindingDB Entry 50017999: Updated chemical scaffolds of ABCG2 inhibitors and their structure-inhibition relationships for future development.

description: Small molecule binding data for protein Broad substrate specificity ATP-binding cassette transporter ABCG2, Uniprot Q9UNQ0
DOI: 10.7270/q29s1w5q
title: BindingDB Entry 50017996: DEAD-Box Helicase DDX3X as a Host Target against Emerging Viruses: New Insights for Medicinal Chemical Approaches.

description: Small molecule binding data for protein ATP-dependent RNA helicase DDX3X, Uniprot O00571
DOI: 10.7270/q2fj2mw1
title: BindingDB Entry 50017995: Recent advance on carbamate-based cholinesterase inhibitors as potential multifunctional agents against Alzheimer's disease.

description: Small molecule binding data for protein Acetylcholinesterase, Amine oxidase [flavin-containing] A, Amine oxidase [flavin-containing] B, Beta-secretase 1, Carbonic anhydrase 1, Carbonic anhydrase 2, Carboxylic ester hydrolase, Cholinesterase, Fatty-acid amide hydrolase 1, High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A, Muscarinic acetylcholine receptor M1, Muscarinic acetylcholine receptor M2, Muscarinic acetylcholine receptor M3, and Sodium-dependent serotonin transporter, Uniprot O42275, O76083, P00915, P00918, P04058, P06276, P08172, P11229, P20309, P21397, P22303, P23795, P27338, P31645, P37136, P56817, P81908, P97612, and Q9JKC1
DOI: 10.7270/q2k64p50
title: BindingDB Entry 50017994: Recent contribution of medicinally active 2-aminothiophenes: A privileged scaffold for drug discovery.

description: Small molecule binding data for protein Epidermal growth factor receptor, Receptor tyrosine-protein kinase erbB-2, and TGF-beta receptor type-1, Uniprot P00533, P04626, and P36897
DOI: 10.7270/q2pz5dw0
title: BindingDB Entry 50017993: Dual-target inhibitors of indoleamine 2, 3 dioxygenase 1 (Ido1): A promising direction in cancer immunotherapy.

description: Small molecule binding data for protein Histone deacetylase 1, Indoleamine 2,3-dioxygenase 1, and Tryptophan 2,3-dioxygenase, Uniprot P14902, P48775, and Q13547
DOI: 10.7270/q2tq65n5
title: BindingDB Entry 50017991: Pan- and isoform-specific inhibition of Hsp90: Design strategy and recent advances.

description: Small molecule binding data for protein Endoplasmin, Heat shock protein 75 kDa, mitochondrial, Heat shock protein HSP 90-alpha, Heat shock protein HSP 90-beta, and Receptor tyrosine-protein kinase erbB-2, Uniprot P04626, P07900, P08238, P41148, and Q12931
DOI: 10.7270/q2zg6xb2
title: BindingDB Entry 50017987: Contemporary mTOR inhibitor scaffolds to diseases breakdown: A patent review (2015-2021).

description: Small molecule binding data for protein Peptidyl-prolyl cis-trans isomerase FKBP1A, Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, Serine/threonine-protein kinase mTOR, Target of rapamycin complex 2 subunit MAPKAP1, and Target of rapamycin complex subunit LST8, Uniprot O00329, P27986, P42336, P42338, P42345, P48736, P62942, Q9BPZ7, and Q9BVC4
DOI: 10.7270/q2377dtb
title: BindingDB Entry 50017985: Emerging impact of triazoles as anti-tubercular agent.

description: Small molecule binding data for protein DNA gyrase subunit B and Pantothenate synthetase, Uniprot P0C559, P9WG45, and P9WIL5
DOI: 10.7270/q27085j2
title: BindingDB Entry 50017983: Discovery of Novel BRD4 Ligand Scaffolds by Automated Navigation of the Fragment Chemical Space.

description: Small molecule binding data for protein Bromodomain-containing protein 4, Uniprot O60885
DOI: 10.5281/zenodo.10388452
title: споменик незнаном јунаку, Хисар

description: локација: 42.991616, 21.937998 // https://goo.gl/maps/CTVopPbmk4zxxFMP7

*фотограметријски модел израђен за потребе израде Студије заштите ратних меморијала општине Лесковац, ЗЗСК Ниш*

тим>>>>><<<<<<
архитекта:    Ивана  Цветковић
историчар:   Ђорђе Стошић
фотограметрија:  Никшић Александар  // https://sketchfab.com/nixic.alexandar

Source: Objaverse 1.0 / Sketchfab
DOI: 10.5281/zenodo.10388453
title: споменик незнаном јунаку, Хисар

description: локација: 42.991616, 21.937998 // https://goo.gl/maps/CTVopPbmk4zxxFMP7

*фотограметријски модел израђен за потребе израде Студије заштите ратних меморијала општине Лесковац, ЗЗСК Ниш*

тим>>>>><<<<<<
архитекта:    Ивана  Цветковић
историчар:   Ђорђе Стошић
фотограметрија:  Никшић Александар  // https://sketchfab.com/nixic.alexandar

Source: Objaverse 1.0 / Sketchfab
DOI: 10.5281/zenodo.10388454
title: Muuksi linnamägi (Estonia)

description: Muuksi linnamägi (with ortophoto) 3D model. Coordinates: 59.51207, 25.52267

Source: Objaverse 1.0 / Sketchfab
DOI: 10.5281/zenodo.10388455
title: Muuksi linnamägi (Estonia)

description: Muuksi linnamägi (with ortophoto) 3D model. Coordinates: 59.51207, 25.52267

Source: Objaverse 1.0 / Sketchfab
DOI: 10.5281/zenodo.10388456
title: Quill VR Inktober 2019 # 23 - Ancient

description: The Sweat Lodge Ceremony

Animated video here!: https://www.youtube.com/watch?v=CLsRiFnFBCE&feature=youtu.be

A lot of people are very skeptical about this (even I was...) so I thought I would share the ancient practice that still is used today throughout various indigenous groups across the world. Myself, a person not of this descent attended a few ceremonies and I felt truly welcomed and it was a really fascinating experience.

The lodge is represented as the "mother's womb" and the most purest place to be healed (once you are born you are exposed to the world's pain and suffering) . In the lodge, you are closed off from the world and in complete darkness as if you are looking at the beginning of life. If felt kind of like an immersive meditation experience.

There is a long explanation online but I highly recommend go trying for yourself. :)

Thank you !
#3Dinktober2019
#3DInktober2019-Ancient

Source: Objaverse 1.0 / Sketchfab
DOI: 10.5281/zenodo.10388457
title: Quill VR Inktober 2019 # 23 - Ancient

description: The Sweat Lodge Ceremony

Animated video here!: https://www.youtube.com/watch?v=CLsRiFnFBCE&feature=youtu.be

A lot of people are very skeptical about this (even I was...) so I thought I would share the ancient practice that still is used today throughout various indigenous groups across the world. Myself, a person not of this descent attended a few ceremonies and I felt truly welcomed and it was a really fascinating experience.

The lodge is represented as the "mother's womb" and the most purest place to be healed (once you are born you are exposed to the world's pain and suffering) . In the lodge, you are closed off from the world and in complete darkness as if you are looking at the beginning of life. If felt kind of like an immersive meditation experience.

There is a long explanation online but I highly recommend go trying for yourself. :)

Thank you !
#3Dinktober2019
#3DInktober2019-Ancient

Source: Objaverse 1.0 / Sketchfab
DOI: 10.5281/zenodo.10388460
title: Untitled

description: Source: Objaverse 1.0 / Sketchfab
DOI: 10.5281/zenodo.10388461
title: Untitled

description: Source: Objaverse 1.0 / Sketchfab
DOI: 10.5281/zenodo.10388462
title: Mosaic Floor Sagalassos

description: Mosaic Floor, 2019 Excavations

The data were collected by Global Digital Heritage in August 2019, as part of the University of Leuven Sagalassos Archaeological Research Project and supported by the Global Heritage Fund.

Source: Objaverse 1.0 / Sketchfab
DOI: 10.5281/zenodo.10388463
title: Mosaic Floor Sagalassos

description: Mosaic Floor, 2019 Excavations

The data were collected by Global Digital Heritage in August 2019, as part of the University of Leuven Sagalassos Archaeological Research Project and supported by the Global Heritage Fund.

Source: Objaverse 1.0 / Sketchfab
DOI: 10.5281/zenodo.10388464
title: Japanese Standing Lantern

description: A low poly Japanese lantern.

Source: Objaverse 1.0 / Sketchfab
DOI: 10.5281/zenodo.10388465
title: Japanese Standing Lantern

description: A low poly Japanese lantern.

Source: Objaverse 1.0 / Sketchfab
DOI: 10.5281/zenodo.10388466
title: Petroglyph N12 Khatm Al Melaha, Kalba, Sharjah

description: Natural Version with paint, Petroglyph N12 Khatm Al Melaha, Kalba, Sharjah. One Syrian Wild Ass. Likely Neolithic or earlier. [Fossati 2019 Messages from the Past: Rock Art of the Al-Hajar Mountains (Oman)].

Khatm Al Melaha is an archaeological site on the coast of the Oman Sea near Kalba in Sharjah, UAE. It is one of the largest rock art sites in the UAE.

Over 175 stones with petroglyphs were documented and close to 400 motifs were identified. Every rock with a glyph was given an ID number and a GPS coordinate. In total 25455 terrestrial photographs, 5244 drone photographs, 44 drone videos, and 182 GPS points (+/- 1cm) were done in a single day.

Petroglyphs were identified using Radiance Scaling in Meshlab, materials lighting in Substance Painter, and by changing conditions in Sketchfab. Some carvings were completely invisible when viewing. Drawings were done only when a line could be identified using one of these techniques.

Reality Capture and Substance Painter

Source: Objaverse 1.0 / Sketchfab
DOI: 10.5281/zenodo.10388467
title: Petroglyph N12 Khatm Al Melaha, Kalba, Sharjah

description: Natural Version with paint, Petroglyph N12 Khatm Al Melaha, Kalba, Sharjah. One Syrian Wild Ass. Likely Neolithic or earlier. [Fossati 2019 Messages from the Past: Rock Art of the Al-Hajar Mountains (Oman)].

Khatm Al Melaha is an archaeological site on the coast of the Oman Sea near Kalba in Sharjah, UAE. It is one of the largest rock art sites in the UAE.

Over 175 stones with petroglyphs were documented and close to 400 motifs were identified. Every rock with a glyph was given an ID number and a GPS coordinate. In total 25455 terrestrial photographs, 5244 drone photographs, 44 drone videos, and 182 GPS points (+/- 1cm) were done in a single day.

Petroglyphs were identified using Radiance Scaling in Meshlab, materials lighting in Substance Painter, and by changing conditions in Sketchfab. Some carvings were completely invisible when viewing. Drawings were done only when a line could be identified using one of these techniques.

Reality Capture and Substance Painter

Source: Objaverse 1.0 / Sketchfab
DOI: 10.5281/zenodo.10388468
title: Ammonite fosilizado

description: Source: Objaverse 1.0 / Sketchfab
DOI: 10.5281/zenodo.10388469
title: Ammonite fosilizado

description: Source: Objaverse 1.0 / Sketchfab
DOI: 10.5281/zenodo.10388470
title: Fragment of pottery of shepherds L1R2.1328

description: Russia, Republic of Bashkortostan, Khaibullinsky district. Excavations in 2001. Settlement of the Bronze Age Laimberdy-1. Plot №2. Square EE10, Level 2. Bronze Age. Chronology: end of the 17th - 16th centuries BC. Alakul culture.
Russland, Republik Baschkortostan, Bezirk Khaibullinsky. Ausgrabungen im Jahr 2001. Be-siedlung der Bronzezeit Laimberdy-1. Ausgrabungsstätte Nr. 2. Quadrat EE10. Level 2. Bronzezeit. Chronologie: Ende des 17. - 16. Jahrhunderts v. Alakul Kultur.
Россия, Республика Башкортостан, Хайбуллинский район. Раскопки 2001 года. Насе-ленный пункт бронзового века Лаимберды-1. Раскоп №2. Квадрат ЕЕ10. Штык №2. Брон-зовый век. Хронология: конец XVII – XVI века до н.э. Алакульская культура.

Source: Objaverse 1.0 / Sketchfab
DOI: 10.5281/zenodo.10388471
title: Fragment of pottery of shepherds L1R2.1328

description: Russia, Republic of Bashkortostan, Khaibullinsky district. Excavations in 2001. Settlement of the Bronze Age Laimberdy-1. Plot №2. Square EE10, Level 2. Bronze Age. Chronology: end of the 17th - 16th centuries BC. Alakul culture.
Russland, Republik Baschkortostan, Bezirk Khaibullinsky. Ausgrabungen im Jahr 2001. Be-siedlung der Bronzezeit Laimberdy-1. Ausgrabungsstätte Nr. 2. Quadrat EE10. Level 2. Bronzezeit. Chronologie: Ende des 17. - 16. Jahrhunderts v. Alakul Kultur.
Россия, Республика Башкортостан, Хайбуллинский район. Раскопки 2001 года. Насе-ленный пункт бронзового века Лаимберды-1. Раскоп №2. Квадрат ЕЕ10. Штык №2. Брон-зовый век. Хронология: конец XVII – XVI века до н.э. Алакульская культура.

Source: Objaverse 1.0 / Sketchfab
DOI: 10.5281/zenodo.10388472
title: Day 89: Saratoga Fountain ll

description: Source: Objaverse 1.0 / Sketchfab
DOI: 10.5281/zenodo.10388473
title: Day 89: Saratoga Fountain ll

description: Source: Objaverse 1.0 / Sketchfab
DOI: 10.5281/zenodo.10388474
title: Zalipie | House of Painters | Slavic Interior

description: Zalipie, a village in southern Poland, is most famous for its folk art. Local artists have been covering houses in traditional floral motifs, a custom with roots back in the 18th century, when housekeepers would lighten sooty interiors of their huts by covering them with limewash. Through the 19th century the practice evolved into a habit of decorating cottages - both on the inside and on the outside - with colorful painted ornaments. The tradition has been kept up in the 20th century by dedicated artists like Felicja Curyłowa (1904-1974) and - thanks to her and her followers - to this day we can admire unique local art, and house painting contests are still held to support this live tradition. The 3D model shows an extraordinary example of a painted interior and was created based on an exhibition room in Dom Malarek (Painters' House) in Zalipie, a cultural center that promotes traditional Zalipie folk art.

Reality Capture: 833 photos in 6 hours overall processing time
Music: Morning Mood by Grieg

Source: Objaverse 1.0 / Sketchfab
DOI: 10.5281/zenodo.10388475
title: Zalipie | House of Painters | Slavic Interior

description: Zalipie, a village in southern Poland, is most famous for its folk art. Local artists have been covering houses in traditional floral motifs, a custom with roots back in the 18th century, when housekeepers would lighten sooty interiors of their huts by covering them with limewash. Through the 19th century the practice evolved into a habit of decorating cottages - both on the inside and on the outside - with colorful painted ornaments. The tradition has been kept up in the 20th century by dedicated artists like Felicja Curyłowa (1904-1974) and - thanks to her and her followers - to this day we can admire unique local art, and house painting contests are still held to support this live tradition. The 3D model shows an extraordinary example of a painted interior and was created based on an exhibition room in Dom Malarek (Painters' House) in Zalipie, a cultural center that promotes traditional Zalipie folk art.

Reality Capture: 833 photos in 6 hours overall processing time
Music: Morning Mood by Grieg

Source: Objaverse 1.0 / Sketchfab
DOI: 10.5281/zenodo.10388476
title: Rail Trail North Bridge

description: Source: Objaverse 1.0 / Sketchfab
DOI: 10.5281/zenodo.10388477
title: Rail Trail North Bridge

description: Source: Objaverse 1.0 / Sketchfab
DOI: 10.5281/zenodo.10388479
title: Tertrapod Footprints - Valentia Island

description: Ireland is littered with wonderful archaeological sites, but not many people are aware that off the south costs on the Island of Valenta lies a set of animal footprints which were made somewhere between 350 and 370 million years ago. 

The Tetrapod (four limbed[foot]) footprints were made by one of the first amphibians and represents the transition of life from water to land – a momentous turning point in evolution and provides the oldest reliably dated evidence of four legged vertebrates (amphibians) moving over land. 

The Valentia Island Tetrapod footprints are the most extensive of the four Devonian trackways in the world. (The others are in Tarbet Ness, Scotland; Genoa River, NSW Australia; Glen Isla, Victoria Australia). Access to the track way is by a pathway down to the rocks.

Source: Objaverse 1.0 / Sketchfab
DOI: 10.5281/zenodo.10388480
title: Passage tomb - Hallebrøndshøj

description: The Hallebrøndshøj (also Grisby Hallebrøndshøj) is a passage grave in a mound and lies west of Grisby near Svaneke on the Danish island of Bornholm. The constructors of the complex, dating between 3500 and 2800 BC, were members of the Neolithic Funnel Beaker Culture.


Hallebrøndshøj has a diameter of about 15 m. The slightly trapezoidal corridor, consists of eleven supporting stones and used to have three deck stones, one of which was preserved in situ and the other fell into the chamber. The North-South oriented chamber is about 4.2 m long, 1.8 m wide and 1.7 m high. Above the short passage in the east with five preserved supporting stones there is a single oversized cap stone, which bears some small cup-marks. 

[wikipedia](https://de.wikipedia.org/wiki/Hallebr%C3%B8ndsh%C3%B8j)

Source: Objaverse 1.0 / Sketchfab
DOI: 10.5281/zenodo.10388481
title: Passage tomb - Hallebrøndshøj

description: The Hallebrøndshøj (also Grisby Hallebrøndshøj) is a passage grave in a mound and lies west of Grisby near Svaneke on the Danish island of Bornholm. The constructors of the complex, dating between 3500 and 2800 BC, were members of the Neolithic Funnel Beaker Culture.


Hallebrøndshøj has a diameter of about 15 m. The slightly trapezoidal corridor, consists of eleven supporting stones and used to have three deck stones, one of which was preserved in situ and the other fell into the chamber. The North-South oriented chamber is about 4.2 m long, 1.8 m wide and 1.7 m high. Above the short passage in the east with five preserved supporting stones there is a single oversized cap stone, which bears some small cup-marks. 

[wikipedia](https://de.wikipedia.org/wiki/Hallebr%C3%B8ndsh%C3%B8j)

Source: Objaverse 1.0 / Sketchfab
DOI: 10.18739/a2ht2gd3g
title: Collaborative Research: An exploration of the direct and indirect effects of climatic warming on arctic lake ecosystems, Fog Lakes, Alaska, 2014-2021

description: We attempted to experimentally warm an arctic whole lake to mimic the effects of on-going climate warming on food web and whole lake ecosystem process and function. The goals were to increase water temperature by up to 4°C (celsius), deepen epilimnion (warmer surface water layer) by up 2 meters (m), and delay ice-on by up to 2 weeks. Logistically this proved very challenging, and took a year or so to figure out the mechanics. By 2018, we had successfully warmed lake Fog 1, with 44 days of heating, a 3°C warmer, deeper epilimnion that mixed 15 days later. We were able to use our lake temperature and warming data to improve upon our ability to simulate lake mixing processes, and were able to predict the lake thermal response to the lake warming manipulation. Those results provide a more complete understanding of lake thermal processes in arctic freshwater lake systems and how they will respond to predicted future warming. For fish growth, one of our primary response variables, we detected an interaction in that growth decreased with increasing temperatures, but only when food availability was low. In addition, our bioenergetic simulations supported our experimental results and suggested that the benefits related to thermoregulation will be highest when food availability is low. In terms of other measured lake factors (e.g., zooplankton, macroinvertebrates) which may have been affected by lake warming, we observed that inter-annual differences among lakes in food web composition and temperature regime tended to overwhelm any potential lake warming responses. In addition, the long, cold winters appear to reset the lakes after warming, with no carryover effects. However, by 2020, the project was largely shut down by the Covid pandemic, and in 2021-2022, by the Covid-based regulations put in place at the field camp. In sum, based on our limited time series of experimental lake warming, these Arctic lakes appear to be somewhat robust to the direct effects of small levels of climatic warming; however, the indirect effects of climate warming and variability (e.g., thermokarst failure [tundra melt and slough]) may be more profound and are under exploration.