cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.6235259.v1
title: Organization of rehabilitation care in Portuguese intensive care units

description: ABSTRACT Objective: To describe the different rehabilitation care models in practice in Portuguese adult intensive care units. Methods: A simple observational (cross-sectional) study was conducted through an online survey sent to the head nurses or individuals responsible for the 58 adult intensive care units that are part of the database of the Sociedade Portuguesa de Cuidados Intensivos. Results: We identified three models of organization of rehabilitation care: care provided by the staff of the intensive care unit (22.9%), care provided by specialized external teams (25.0%), and a mixture of the previous models, combining the two situations (52.1%). In the first model, the care was provided mainly by nurses with specialization in rehabilitation and, in the second model, the care was provided by physiotherapists. No significant differences were found between the models regarding the availability of care, in hours/day or days/week (p = 0.268 and 0.994, respectively), or results such as length of hospital stay in intensive care, ventilation time, or mortality rate in the unit (p = 0.418, 0.923, and 0.240, respectively). Conclusion: The organization of rehabilitation care in Portuguese intensive care units is unique and heterogeneous. Despite different care organization models, the availability of hours of care is similar, as are the overall results observed in patients.
DOI: 10.6084/m9.figshare.6235256
title: Pedagogy Licentiate Mathematics Education: an analysis in the light of the methodologic pluralism

description: Abstract The research has as main objective the analysis of the operations made by future teachers, after the degree course for Mathematics teaching. It presents a qualitative approach, using the interpretive study as a methodological strategy. The study was developed in a Pedagogy Course class of a Private Higher Education Institution, in a city in the countryside of the state of Parana, Brazil. The theoretical reference brings contributions from studies made about those contents elaboration, as well as the contributions of Feyerabend's ideas on the methodological pluralism usage. The results pointed out the domination of a rationalist profile, since it was possible to observe minimal changes in the epistemological posture of the surveyed students, after concluding the educational stage.
DOI: 10.6084/m9.figshare.6235256.v1
title: Pedagogy Licentiate Mathematics Education: an analysis in the light of the methodologic pluralism

description: Abstract The research has as main objective the analysis of the operations made by future teachers, after the degree course for Mathematics teaching. It presents a qualitative approach, using the interpretive study as a methodological strategy. The study was developed in a Pedagogy Course class of a Private Higher Education Institution, in a city in the countryside of the state of Parana, Brazil. The theoretical reference brings contributions from studies made about those contents elaboration, as well as the contributions of Feyerabend's ideas on the methodological pluralism usage. The results pointed out the domination of a rationalist profile, since it was possible to observe minimal changes in the epistemological posture of the surveyed students, after concluding the educational stage.
DOI: 10.6084/m9.figshare.6235253
title: Massive hemoptysis successfully treated with extracorporeal membrane oxygenation and endobronchial thrombolysis

description: ABSTRACT Extracorporeal membrane oxygenation has been used to treat refractory hypoxemia in numerous clinical scenarios. The fundamental principles for the management of massive hemoptysis patients include protecting the airway and healthy lung, locating the source of bleeding and controlling the hemorrhage. We report the case of a patient with acute respiratory failure associated with massive hemoptysis secondary to lung laceration during cardiac surgery. The use of extracorporeal membrane oxygenation allowed patient survival. However, due to the great difficulty in managing pulmonary clots after hemoptysis, it was necessary to use an unusual therapy involving endobronchial infusion of a thrombolytic agent as described in rare cases in the literature.
DOI: 10.6084/m9.figshare.6235253.v1
title: Massive hemoptysis successfully treated with extracorporeal membrane oxygenation and endobronchial thrombolysis

description: ABSTRACT Extracorporeal membrane oxygenation has been used to treat refractory hypoxemia in numerous clinical scenarios. The fundamental principles for the management of massive hemoptysis patients include protecting the airway and healthy lung, locating the source of bleeding and controlling the hemorrhage. We report the case of a patient with acute respiratory failure associated with massive hemoptysis secondary to lung laceration during cardiac surgery. The use of extracorporeal membrane oxygenation allowed patient survival. However, due to the great difficulty in managing pulmonary clots after hemoptysis, it was necessary to use an unusual therapy involving endobronchial infusion of a thrombolytic agent as described in rare cases in the literature.
DOI: 10.6084/m9.figshare.6235250
title: Biomarkers of cardio-renal syndrome in uremic myocardiopathy animal model

description: ABSTRACT Introduction: Cardio-renal syndrome subtype 4 (CRS4) is a condition of primary chronic kidney disease that leads to reduction of cardiac function, ventricular hypertrophy, and risk of cardiovascular events. Objective: Our aim was to understand the mechanisms involved on the onset of CRS4. Methods: We used the nephrectomy 5/6 (CKD) animal model and compared to control (SHAM). Serum biomarkers were analyzed at baseline, 4, and 8 weeks. After euthanasia, histology and immunohistochemistry were performed in the myocardium. Results: Troponin I (TnI) was increased at 4 weeks (W) and 8W, but nt-proBNP showed no difference. The greater diameter of cardiomyocytes indicated left ventricular hypertrophy and the highest levels of TNF-α were found at 4W declining in 8W while fibrosis was more intense in 8W. Angiotensin expression showed an increase at 8W. Conclusions: TnI seems to reflect cardiac injury as a consequence of the CKD however nt-proBNP did not change because it reflects stretching. TNF-α characterized an inflammatory peak and fibrosis increased over time in a process connecting heart and kidneys. The angiotensin showed increased activity of the renin-angiotensin axis and corroborates the hypothesis that the inflammatory process and its involvement with CRS4. Therefore, this animal study reinforces the need for renin-angiotensin blockade strategies and the control of CKD to avoid the development of CRS4.
DOI: 10.6084/m9.figshare.6235250.v1
title: Biomarkers of cardio-renal syndrome in uremic myocardiopathy animal model

description: ABSTRACT Introduction: Cardio-renal syndrome subtype 4 (CRS4) is a condition of primary chronic kidney disease that leads to reduction of cardiac function, ventricular hypertrophy, and risk of cardiovascular events. Objective: Our aim was to understand the mechanisms involved on the onset of CRS4. Methods: We used the nephrectomy 5/6 (CKD) animal model and compared to control (SHAM). Serum biomarkers were analyzed at baseline, 4, and 8 weeks. After euthanasia, histology and immunohistochemistry were performed in the myocardium. Results: Troponin I (TnI) was increased at 4 weeks (W) and 8W, but nt-proBNP showed no difference. The greater diameter of cardiomyocytes indicated left ventricular hypertrophy and the highest levels of TNF-α were found at 4W declining in 8W while fibrosis was more intense in 8W. Angiotensin expression showed an increase at 8W. Conclusions: TnI seems to reflect cardiac injury as a consequence of the CKD however nt-proBNP did not change because it reflects stretching. TNF-α characterized an inflammatory peak and fibrosis increased over time in a process connecting heart and kidneys. The angiotensin showed increased activity of the renin-angiotensin axis and corroborates the hypothesis that the inflammatory process and its involvement with CRS4. Therefore, this animal study reinforces the need for renin-angiotensin blockade strategies and the control of CKD to avoid the development of CRS4.
DOI: 10.6084/m9.figshare.6235247
title: Hydralazine-associated adverse events: a report of two cases of hydralazine-induced ANCA vasculitis

description: Abstract Hydralazine is a direct-acting vasodilator, which has been used in treatment for hypertension (HTN) since the 1950s. While it is well known to cause drug-induced lupus (DIL), recent reports are indicating the emergence of the drug-induced anti-neutrophil cytoplasmic antibody (ANCA) associated vasculitis (DIV). Herein, we describe two patients (aged 57 and 87 years) who presented with severe acute kidney injury (AKI), proteinuria, and hematuria. Both were receiving hydralazine for the treatment of hypertension. ANCA serology was positive in both patients along with anti-histone antibodies (commonly seen in drug-induced vasculitis). Renal biopsy revealed classic crescentic (pauci-immune) glomerulonephritis in these patients and hydralazine was discontinued. During the hospital course, the 57-year-old patient required dialysis therapy and was treated with steroids and rituximab for the ANCA disease. Renal function improved and the patient was discharged (off dialysis) with a serum creatinine of 3.6 mg/dL (baseline = 0.9 mg/dL). At a follow-up of 2 years, the patient remained off dialysis with advanced chronic kidney disease (CKD) (stage IIIb). The 87-year-old patient had severe AKI with serum creatinine at 10.41 mg/dL (baseline = 2.27 mg/dL). The patient required hemodialysis and was treated with steroids, rituximab, and plasmapheresis. Unfortunately, the patient developed catheter-induced bacteremia and subsequently died of sepsis. Hydralazine can cause severe AKI resulting in CKD or death. Given this extremely unfavorable adverse-event profile and the widespread availability of alternative anti-hypertensive agents, the use of hydralazine should be carefully considered.
DOI: 10.6084/m9.figshare.6235247.v1
title: Hydralazine-associated adverse events: a report of two cases of hydralazine-induced ANCA vasculitis

description: Abstract Hydralazine is a direct-acting vasodilator, which has been used in treatment for hypertension (HTN) since the 1950s. While it is well known to cause drug-induced lupus (DIL), recent reports are indicating the emergence of the drug-induced anti-neutrophil cytoplasmic antibody (ANCA) associated vasculitis (DIV). Herein, we describe two patients (aged 57 and 87 years) who presented with severe acute kidney injury (AKI), proteinuria, and hematuria. Both were receiving hydralazine for the treatment of hypertension. ANCA serology was positive in both patients along with anti-histone antibodies (commonly seen in drug-induced vasculitis). Renal biopsy revealed classic crescentic (pauci-immune) glomerulonephritis in these patients and hydralazine was discontinued. During the hospital course, the 57-year-old patient required dialysis therapy and was treated with steroids and rituximab for the ANCA disease. Renal function improved and the patient was discharged (off dialysis) with a serum creatinine of 3.6 mg/dL (baseline = 0.9 mg/dL). At a follow-up of 2 years, the patient remained off dialysis with advanced chronic kidney disease (CKD) (stage IIIb). The 87-year-old patient had severe AKI with serum creatinine at 10.41 mg/dL (baseline = 2.27 mg/dL). The patient required hemodialysis and was treated with steroids, rituximab, and plasmapheresis. Unfortunately, the patient developed catheter-induced bacteremia and subsequently died of sepsis. Hydralazine can cause severe AKI resulting in CKD or death. Given this extremely unfavorable adverse-event profile and the widespread availability of alternative anti-hypertensive agents, the use of hydralazine should be carefully considered.
DOI: 10.6084/m9.figshare.6235244
title: Evaluation of prevalence, biochemical profile, and drugs associated with chronic kidney disease-mineral and bone disorder in 11 dialysis centers

description: ABSTRACT Introduction: The diagnosis and treatment of mineral and bone disorder of chronic kidney disease (CKD-MBD) is a challenge for nephrologists and health managers. The aim of this study was to evaluate the prevalence, biochemical profile, and drugs associated with CKD-MBD. Methods: Cross-sectional study between July and November 2013, with 1134 patients on dialysis. Sociodemographic, clinical, and laboratory data were compared between groups based on levels of intact parathyroid hormone (iPTH) (&lt; 150, 150-300, 301-600, 601-1000, and &gt; 1001 pg/mL). Results: The mean age was 57.3 ± 14.4 years. The prevalence of iPTH &lt; 150 pg/mL was 23.4% and iPTH &gt; 601 pg/mL was 27.1%. The comparison between the groups showed that the level of iPTH decreased with increasing age. Diabetic patients had a higher prevalence of iPTH &lt; 150 pg/mL (27.6%). Hyperphosphatemia (&gt; 5.5 mg/dL) was observed in 35.8%. Calcium carbonate was used by 50.5%, sevelamer by 14.7%, 40% of patients had used some form of vitamin D and 3.5% used cinacalcet. Linear regression analysis showed a significant negative association between iPTH, age, and diabetes mellitus and a significant positive association between iPTH and dialysis time. Conclusion: The prevalence of patients outside the target for iPTH was 50.5%. There was a high prevalence of hyperphosphatemia (35.8%), and the minority of patients were using active vitamin D, vitamin D analogs, selective vitamin D receptor activators, and cinacalcet. These data indicate the need for better compliance with clinical guidelines and public policies on the supply of drugs associated with CKD-MBD.
DOI: 10.6084/m9.figshare.6235244.v1
title: Evaluation of prevalence, biochemical profile, and drugs associated with chronic kidney disease-mineral and bone disorder in 11 dialysis centers

description: ABSTRACT Introduction: The diagnosis and treatment of mineral and bone disorder of chronic kidney disease (CKD-MBD) is a challenge for nephrologists and health managers. The aim of this study was to evaluate the prevalence, biochemical profile, and drugs associated with CKD-MBD. Methods: Cross-sectional study between July and November 2013, with 1134 patients on dialysis. Sociodemographic, clinical, and laboratory data were compared between groups based on levels of intact parathyroid hormone (iPTH) (&lt; 150, 150-300, 301-600, 601-1000, and &gt; 1001 pg/mL). Results: The mean age was 57.3 ± 14.4 years. The prevalence of iPTH &lt; 150 pg/mL was 23.4% and iPTH &gt; 601 pg/mL was 27.1%. The comparison between the groups showed that the level of iPTH decreased with increasing age. Diabetic patients had a higher prevalence of iPTH &lt; 150 pg/mL (27.6%). Hyperphosphatemia (&gt; 5.5 mg/dL) was observed in 35.8%. Calcium carbonate was used by 50.5%, sevelamer by 14.7%, 40% of patients had used some form of vitamin D and 3.5% used cinacalcet. Linear regression analysis showed a significant negative association between iPTH, age, and diabetes mellitus and a significant positive association between iPTH and dialysis time. Conclusion: The prevalence of patients outside the target for iPTH was 50.5%. There was a high prevalence of hyperphosphatemia (35.8%), and the minority of patients were using active vitamin D, vitamin D analogs, selective vitamin D receptor activators, and cinacalcet. These data indicate the need for better compliance with clinical guidelines and public policies on the supply of drugs associated with CKD-MBD.
DOI: 10.6084/m9.figshare.6235241
title: Chromium contents linked to iron oxide at areas with tannery sludge disposal

description: ABSTRACT The tannery sludge disposal in the soil has been a serious environmental problem due to the high chromium concentrations. The aim of this study was to evaluate the iron oxides dynamic and chromium concentrations linked to these minerals in areas of tannery sludge disposal. So, concentration of iron and chromium extracted with ammonium oxalate from oxides with low crystallinity and with dithionite-citrate-bicarbonate from the crystalline oxides in the clay fraction was evaluated. The concentration of chromium extracted from the iron oxides with low crystallinity varied between 3.5 and 4.1 mg kg-1 in the treatments without application of tannery, and between 19.9 and 56.8 mg kg-1 in the treatments with tannery application. The concentration of chromium extracted from the crystalline oxides varied between 21.3 and 23.3 mg kg-1 in the treatments without application of tannery sludge, and between 46.4 and 103.0 mg kg-1 in the treatments with tannery. The application of tannery promoted an increase in the relation between the iron extracted from the iron oxides and the iron extracted with dithionite (Feo/Fed) and the oxides from the disposal area, which is an evidence of the oxide crystallinity decrease. A reduction was found in the relation between the iron extracted with dithionite and the chromium extracted with dithionite (Fed/Crd), what shows the substitution of the iron by chromium in the oxides, emphasizing an isomorphic substitution. This isomorphic substitution can be an alternative to maintain the chromium in the soil with strong retention.
DOI: 10.6084/m9.figshare.6235241.v1
title: Chromium contents linked to iron oxide at areas with tannery sludge disposal

description: ABSTRACT The tannery sludge disposal in the soil has been a serious environmental problem due to the high chromium concentrations. The aim of this study was to evaluate the iron oxides dynamic and chromium concentrations linked to these minerals in areas of tannery sludge disposal. So, concentration of iron and chromium extracted with ammonium oxalate from oxides with low crystallinity and with dithionite-citrate-bicarbonate from the crystalline oxides in the clay fraction was evaluated. The concentration of chromium extracted from the iron oxides with low crystallinity varied between 3.5 and 4.1 mg kg-1 in the treatments without application of tannery, and between 19.9 and 56.8 mg kg-1 in the treatments with tannery application. The concentration of chromium extracted from the crystalline oxides varied between 21.3 and 23.3 mg kg-1 in the treatments without application of tannery sludge, and between 46.4 and 103.0 mg kg-1 in the treatments with tannery. The application of tannery promoted an increase in the relation between the iron extracted from the iron oxides and the iron extracted with dithionite (Feo/Fed) and the oxides from the disposal area, which is an evidence of the oxide crystallinity decrease. A reduction was found in the relation between the iron extracted with dithionite and the chromium extracted with dithionite (Fed/Crd), what shows the substitution of the iron by chromium in the oxides, emphasizing an isomorphic substitution. This isomorphic substitution can be an alternative to maintain the chromium in the soil with strong retention.
DOI: 10.6084/m9.figshare.6235238
title: SOCIAL COUPLING AND DECOUPLING: PASTORS AS ENTREPRENEURS

description: ABSTRACT Neo-Pentecostal ministers, whose churches follow productive enterprise patterns, seem to be endowed with the ability to build new social relations-linked to the religious context-while concurrently moving away from previous links, especially those with family and friends. This coupling (the creation of and linkage to new bonds) and decoupling capacity (distancing oneself from past relationships) was first observed by Granovetter (2009) while investigating immigrant entrepreneurs. This article goes beyond the scope of his studies, where the displacement factor was ethnic-geographical, to analyze a new phenomenon of an ethical-religious nature. In order to do so, it introduces the cases of 16 pastors in the metropolitan region of Belo Horizonte, Brazil. Evidence is found of the importance of the coupling/decoupling phenomenon in the creation of new religious communities, which are widespread throughout the country. At the same time, this study makes new contributions to the field and opens up different lines of research.
DOI: 10.6084/m9.figshare.6235238.v1
title: SOCIAL COUPLING AND DECOUPLING: PASTORS AS ENTREPRENEURS

description: ABSTRACT Neo-Pentecostal ministers, whose churches follow productive enterprise patterns, seem to be endowed with the ability to build new social relations-linked to the religious context-while concurrently moving away from previous links, especially those with family and friends. This coupling (the creation of and linkage to new bonds) and decoupling capacity (distancing oneself from past relationships) was first observed by Granovetter (2009) while investigating immigrant entrepreneurs. This article goes beyond the scope of his studies, where the displacement factor was ethnic-geographical, to analyze a new phenomenon of an ethical-religious nature. In order to do so, it introduces the cases of 16 pastors in the metropolitan region of Belo Horizonte, Brazil. Evidence is found of the importance of the coupling/decoupling phenomenon in the creation of new religious communities, which are widespread throughout the country. At the same time, this study makes new contributions to the field and opens up different lines of research.
DOI: 10.6084/m9.figshare.6235235
title: Complement activation in atypical hemolytic uremic syndrome and scleroderma renal crisis: a critical analysis of pathophysiology

description: ABSTRACT Scleroderma is an autoimmune disease that affects multiple systems. While pathophysiologic mechanisms governing the development of scleroderma are relatively poorly understood, advances in our understanding of the complement system are clarifying the role of complement pathways in the development of atypical hemolytic uremic syndrome and scleroderma renal crisis. The abundant similarities in their presentation as well as the clinical course are raising the possibility of a common underlying pathogenesis. Recent reports are emphasizing that complement pathways appear to be the unifying link. This article reviews the role of complement system in the development of atypical hemolytic uremic syndrome and scleroderma renal crisis, and calls for heightened awareness to the development of thrombotic angiopathy in patients with scleroderma.
DOI: 10.6084/m9.figshare.6235235.v1
title: Complement activation in atypical hemolytic uremic syndrome and scleroderma renal crisis: a critical analysis of pathophysiology

description: ABSTRACT Scleroderma is an autoimmune disease that affects multiple systems. While pathophysiologic mechanisms governing the development of scleroderma are relatively poorly understood, advances in our understanding of the complement system are clarifying the role of complement pathways in the development of atypical hemolytic uremic syndrome and scleroderma renal crisis. The abundant similarities in their presentation as well as the clinical course are raising the possibility of a common underlying pathogenesis. Recent reports are emphasizing that complement pathways appear to be the unifying link. This article reviews the role of complement system in the development of atypical hemolytic uremic syndrome and scleroderma renal crisis, and calls for heightened awareness to the development of thrombotic angiopathy in patients with scleroderma.