cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.5394871.v1
title: Computational design of Phe-Tyr dipeptide and preparation, characterization, cytotoxicity studies of Phe-Tyr dipeptide loaded PLGA nanoparticles for the treatment of hypertension

description: Phe-Tyr dipeptide which was investigated in Wakame food with greatest ACE-inhibitory activity is used as a pharmaceutical drug for the treatment of hypertension, cardiovascular diseases, and diabetic nephropathy. To improve the bioavailability of Phe-Tyr, a delivery system based on poly (lactic-co-glycolic acid) (PLGA) nanoparticles loaded with Phe-Tyr (Phe-Tyr-PLGA NPs) for treating hypertension and cardiovascular diseases was prepared in this study. In the experiments, poly(lactic-co-glycolic acid) (PLGA) and Phe-Tyr dipeptide-loaded PLGA nanoparticles were prepared using the double emulsion (w/o/w) method. The characterizations of the nanoparticles were performed with a UV–vis spectrometer, the Zeta-sizer system, and FTIR spectrometer. The optimum size of the Phe-Tyr dipeptide-loaded PLGA nanoparticle was obtained with a 213.8 nm average particle size, and a 0.061 polydispersity index, −19.5 mV zeta potential, 34% of loaded and 90.09% of encapsulation efficiency. From TEM analysis, it was clearly seen that the dipeptide loaded nanoparticles had the spherical and non-aggregated morphology and Phe-Tyr dipeptide loaded-PLGA nanoparticles were obtained successfully. Cell toxicity of nanoparticles at different concentrations was assayed with XTT methods on L929 fibroblast cells. This study determined that the nanoparticles have low toxicity at lower concentration and toxicity augmented with increasing concentration of dipeptide. To analyze the effect of solvents on structure of Phe-Tyr, Molecular dynamics simulation was performed with GROMACS program and molecular orbital calculations were carried out to obtain structural and electronic properties of dipeptide. Moreover, molecular docking calculations were also employed to model and predict protein–drug interactions.
DOI: 10.6084/m9.figshare.5394895.v1
title: GENOMIC DIVERSITY AND POPULATION STRUCTURE OF THE MEXICAN AND SPANISH BOVINE LIDIA BREED

description: This dataset repository contains the files of the Lidia breed individuals used for the genomic analyses made out from SNP data. <br>
DOI: 10.6084/m9.figshare.5394865.v1
title: 001_OTB1_Tow.xlsx

description: Recently the climate-abusing effects of exhaust gases from combustion processes have been increasingly focused. This is underlining the importance of improving the energy efficiency. Nowadays, fishing fleet is in most cases not efficient because of outdated technology. Maintaining an adequate level of energy efficiency requires a continuous monitoring of the energy profile of the vessel. Any causes of energy inefficiency can be identified, being able to act on them promptly and effectively. A proper system of energy use monitoring is therefore essential for maintaining high-energy efficiency. Once energy use has been related to each operating condition, fishers can minimize fuel use. Energy efficiency in fisheries can be investigated through Energy Audit, which allows obtaining an extensive energy profile of the fishing vessels monitored. Vessel Energy Audit assesses the energy consumption of each energy user (e.g. propulsion system, electric- and hydraulic-user). Energy audits have been conducted for fishing vessels, which lead to recommendations for improved efficiencies to solve present and possible future fuel cost increases.
DOI: 10.6084/m9.figshare.5394895.v2
title: GENOMIC DIVERSITY AND POPULATION STRUCTURE OF THE MEXICAN AND SPANISH BOVINE LIDIA BREED

description: This dataset repository contains the files of the Lidia breed individuals used for the genomic analyses made out from SNP data. <br>
DOI: 10.6084/m9.figshare.5394895.v3
title: GENOMIC DIVERSITY AND POPULATION STRUCTURE OF THE MEXICAN AND SPANISH BOVINE LIDIA BREED

description: This dataset repository contains the files of the Lidia breed individuals used for the genomic analyses made out from SNP data. <br>
DOI: 10.18112/openneuro.ds003097.v1.1.0
title: AOMIC-ID1000
DOI: 10.6084/m9.figshare.5394817
title: count table.gz

description: Count table for the final model for the paper:Bertl, J.; Guo, Q.; Rasmussen, M. J.; Besenbacher, S; Nielsen, M. M.; Hornshøj, H.; Pedersen, J. S. & Hobolth, A. A Site Specific Model And Analysis Of The Neutral Somatic Mutation Rate In Whole-Genome Cancer Data.<br>
DOI: 10.6084/m9.figshare.5394796
title: SensePlace3: a geovisual framework to analyze place–time–attribute information in social media

description: SensePlace3 (SP3) is a geovisual analytics framework and web application that supports overview + detail analysis of social media, focusing on extracting meaningful information from the Twitterverse. SP3 leverages social media related to crisis events. It differs from most existing systems by enabling an analyst to obtain place-relevant information from tweets that have implicit as well as explicit geography. Specifically, SP3 includes not just the ability to utilize the explicit geography of geolocated tweets but also analyze implicit geography by recognizing and geolocating references in both tweet text, which indicates locations tweeted <i>about</i>, and in Twitter profiles, which indicates locations affiliated with users. Key features of SP3 reported here include flexible search and filtering capabilities to support information foraging; an ingest, processing, and indexing pipeline that produces near real-time access for big streaming data; and a novel strategy for implementing a web-based multi-view visual interface with dynamic linking of entities across views. The SP3 system architecture was designed to support crisis management applications, but its design flexibility makes it easily adaptable to other domains. We also report on a user study that provided input to SP3 interface design and suggests next steps for effective spatiotemporal analytics using social media sources.
DOI: 10.6084/m9.figshare.5394817.v1
title: count_table.gz

description: Count table for the final model for the paper:Bertl, J.; Guo, Q.; Rasmussen, M. J.; Besenbacher, S; Nielsen, M. M.; Hornshøj, H.; Pedersen, J. S. & Hobolth, A. A Site Specific Model And Analysis Of The Neutral Somatic Mutation Rate In Whole-Genome Cancer Data.<br>
DOI: 10.6084/m9.figshare.5394787
title: parameters for the final model

description: Parameters for the final model for the paper:Bertl, J.; Guo, Q.; Rasmussen, M. J.; Besenbacher, S; Nielsen, M. M.; Hornshøj, H.; Pedersen, J. S. & Hobolth, A. A Site Specific Model And Analysis Of The Neutral Somatic Mutation Rate In Whole-Genome Cancer Data.
DOI: 10.6084/m9.figshare.5394796.v1
title: SensePlace3: a geovisual framework to analyze place–time–attribute information in social media

description: SensePlace3 (SP3) is a geovisual analytics framework and web application that supports overview + detail analysis of social media, focusing on extracting meaningful information from the Twitterverse. SP3 leverages social media related to crisis events. It differs from most existing systems by enabling an analyst to obtain place-relevant information from tweets that have implicit as well as explicit geography. Specifically, SP3 includes not just the ability to utilize the explicit geography of geolocated tweets but also analyze implicit geography by recognizing and geolocating references in both tweet text, which indicates locations tweeted <i>about</i>, and in Twitter profiles, which indicates locations affiliated with users. Key features of SP3 reported here include flexible search and filtering capabilities to support information foraging; an ingest, processing, and indexing pipeline that produces near real-time access for big streaming data; and a novel strategy for implementing a web-based multi-view visual interface with dynamic linking of entities across views. The SP3 system architecture was designed to support crisis management applications, but its design flexibility makes it easily adaptable to other domains. We also report on a user study that provided input to SP3 interface design and suggests next steps for effective spatiotemporal analytics using social media sources.
DOI: 10.6084/m9.figshare.5394787.v1
title: parameters for the final model

description: Parameters for the final model for the paper:Bertl, J.; Guo, Q.; Rasmussen, M. J.; Besenbacher, S; Nielsen, M. M.; Hornshøj, H.; Pedersen, J. S. & Hobolth, A. A Site Specific Model And Analysis Of The Neutral Somatic Mutation Rate In Whole-Genome Cancer Data.
DOI: 10.6084/m9.figshare.5394739
title: Practising what you preach: how cosmopolitanism promotes willingness to redistribute across the European Union

description: The political fault lines surrounding the European sovereign debt crisis have underlined the political relevance and the fragile foundation of public support for international redistribution in the European Union. Against the backdrop of an emerging political integration-demarcation divide, this contribution examines how cosmopolitanism structures people’s willingness to redistribute internationally within the European Union. To this aim, we conducted laboratory experiments on <i>redistributive behaviour</i> towards other European citizens in the United Kingdom and Germany and analysed cross-national survey data on <i>support for international redistribution</i> covering the EU-28. Our findings suggest that cosmopolitanism increases generosity towards other Europeans and support for international redistribution even when controlling for self-interest, support for national redistribution, concern for others and political ideology.
DOI: 10.6084/m9.figshare.5394739.v1
title: Practising what you preach: how cosmopolitanism promotes willingness to redistribute across the European Union

description: The political fault lines surrounding the European sovereign debt crisis have underlined the political relevance and the fragile foundation of public support for international redistribution in the European Union. Against the backdrop of an emerging political integration-demarcation divide, this contribution examines how cosmopolitanism structures people’s willingness to redistribute internationally within the European Union. To this aim, we conducted laboratory experiments on <i>redistributive behaviour</i> towards other European citizens in the United Kingdom and Germany and analysed cross-national survey data on <i>support for international redistribution</i> covering the EU-28. Our findings suggest that cosmopolitanism increases generosity towards other Europeans and support for international redistribution even when controlling for self-interest, support for national redistribution, concern for others and political ideology.
DOI: 10.6084/m9.figshare.5394685
title: Barramundi growth data from Fish face a trade-off between ‘eating big’ for growth efficiency and ‘eating small’ to retain aerobic capacity

description: Feeding provides the necessary energy to fuel all fitness-related processes including activity, growth and reproduction. Nevertheless, prey consumption and digestive processes can have physical and physiological trade-offs with other critical functions, many of which are not clearly understood. Using an ambush predator, barramundi (<i>Lates calcarifer</i>), fed meals ranging 0.6–3.4% of body mass, we examined interrelations between meal size, growth efficiency and surplus aerobic metabolic capacity (aerobic scope, AS). Large meals required a greater absolute investment of energy to process (a larger so-called specific dynamic action, SDA), but the percentage of digestible meal energy required in the SDA response (SDA coefficient) decreased with increasing meal size. Combined with the findings that growth rate and growth efficiency also increased with food intake, our results demonstrate that it is energetically advantageous for fish to select large prey. However, following a large meal, SDA processes occupied up to 77% of the available AS, indicating that other oxygen-demanding activities like swimming may be compromised while large meals are processed. This trade-off between meal size and AS suggests that fishes like barramundi would benefit from regulating prey size based on imminent requirements and threats.
DOI: 10.6084/m9.figshare.5394691
title: Coefficients of the stream function from Irreversible particle motion in surfactant-laden interfaces due to pressure-dependent surface viscosity

description: Coefficients of the stream function solution for the general case of a cylinder within a cylinder enclosing a 2D Newtonian fluid
DOI: 10.6084/m9.figshare.5394685.v1
title: Barramundi growth data from Fish face a trade-off between ‘eating big’ for growth efficiency and ‘eating small’ to retain aerobic capacity

description: Feeding provides the necessary energy to fuel all fitness-related processes including activity, growth and reproduction. Nevertheless, prey consumption and digestive processes can have physical and physiological trade-offs with other critical functions, many of which are not clearly understood. Using an ambush predator, barramundi (<i>Lates calcarifer</i>), fed meals ranging 0.6–3.4% of body mass, we examined interrelations between meal size, growth efficiency and surplus aerobic metabolic capacity (aerobic scope, AS). Large meals required a greater absolute investment of energy to process (a larger so-called specific dynamic action, SDA), but the percentage of digestible meal energy required in the SDA response (SDA coefficient) decreased with increasing meal size. Combined with the findings that growth rate and growth efficiency also increased with food intake, our results demonstrate that it is energetically advantageous for fish to select large prey. However, following a large meal, SDA processes occupied up to 77% of the available AS, indicating that other oxygen-demanding activities like swimming may be compromised while large meals are processed. This trade-off between meal size and AS suggests that fishes like barramundi would benefit from regulating prey size based on imminent requirements and threats.
DOI: 10.6084/m9.figshare.5394691.v1
title: Coefficients of the stream function from Irreversible particle motion in surfactant-laden interfaces due to pressure-dependent surface viscosity

description: Coefficients of the stream function solution for the general case of a cylinder within a cylinder enclosing a 2D Newtonian fluid
DOI: 10.6084/m9.figshare.5394676
title: Coefficients of the stream function from Irreversible particle motion in surfactant-laden interfaces due to pressure-dependent surface viscosity

description: Coefficients of the stream function solution for the general case of a cylinder within a cylinder enclosing a 2D Newtonian fluid
DOI: 10.6084/m9.figshare.5394676.v1
title: Coefficients of the stream function from Irreversible particle motion in surfactant-laden interfaces due to pressure-dependent surface viscosity

description: Coefficients of the stream function solution for the general case of a cylinder within a cylinder enclosing a 2D Newtonian fluid
DOI: 10.6084/m9.figshare.5394655
title: Appendix B from Monarch butterfly population decline in North America: identifying the threatening processes

description: R Code used in analyses. (File name MonarchThreatsCode.r)
DOI: 10.6084/m9.figshare.5394655.v1
title: Appendix B from Monarch butterfly population decline in North America: identifying the threatening processes

description: R Code used in analyses. (File name MonarchThreatsCode.r)
DOI: 10.6084/m9.figshare.5394649
title: Barramundi MO2 and SDA data from Fish face a trade-off between ‘eating big’ for growth efficiency and ‘eating small’ to retain aerobic capacity

description: Feeding provides the necessary energy to fuel all fitness-related processes including activity, growth and reproduction. Nevertheless, prey consumption and digestive processes can have physical and physiological trade-offs with other critical functions, many of which are not clearly understood. Using an ambush predator, barramundi (<i>Lates calcarifer</i>), fed meals ranging 0.6–3.4% of body mass, we examined interrelations between meal size, growth efficiency and surplus aerobic metabolic capacity (aerobic scope, AS). Large meals required a greater absolute investment of energy to process (a larger so-called specific dynamic action, SDA), but the percentage of digestible meal energy required in the SDA response (SDA coefficient) decreased with increasing meal size. Combined with the findings that growth rate and growth efficiency also increased with food intake, our results demonstrate that it is energetically advantageous for fish to select large prey. However, following a large meal, SDA processes occupied up to 77% of the available AS, indicating that other oxygen-demanding activities like swimming may be compromised while large meals are processed. This trade-off between meal size and AS suggests that fishes like barramundi would benefit from regulating prey size based on imminent requirements and threats.
DOI: 10.6084/m9.figshare.5394652
title: Electronic_supplementary_tables from Into the dark: patterns of middle ear adaptations in subterranean eulipotyphlan mammals

description: Evolution of the middle ear ossicles was a key innovation for mammals, enhancing the transmission of airborne sound. Radiation into various habitats from a terrestrial environment resulted in diversification of the auditory mechanisms among mammals. However, due to the paucity of phylogenetically controlled investigations, how middle ear traits have diversified with functional specialization remains unclear. In order to identify the respective patterns for various lifestyles and to gain insights into fossil forms, we employed a high-resolution tomography technique and compared the middle ear morphology of eulipotyphlan species (moles, shrews and hedgehogs), a group that has radiated into various environments, such as terrestrial, aquatic and subterranean habitats. Three-dimensional geometric morphometric analysis was conducted within a phylogenetically controlled framework. Quantitative shapes were found to strongly reflect the degree of subterranean lifestyle and weakly involve phylogeny. Our analyses demonstrate that subterranean adaptation should include a relatively shorter anterior process of the malleus, an enlarged incus, an enlarged stapes footplate and a reduction of the orbicular apophysis. These traits arguably allow improving low-frequency sound transmission at low frequencies and inhibiting the low-frequency noise which disturbs the subterranean animals to hear airborne sounds.
DOI: 10.6084/m9.figshare.5394649.v1
title: Barramundi MO2 and SDA data from Fish face a trade-off between ‘eating big’ for growth efficiency and ‘eating small’ to retain aerobic capacity

description: Feeding provides the necessary energy to fuel all fitness-related processes including activity, growth and reproduction. Nevertheless, prey consumption and digestive processes can have physical and physiological trade-offs with other critical functions, many of which are not clearly understood. Using an ambush predator, barramundi (<i>Lates calcarifer</i>), fed meals ranging 0.6–3.4% of body mass, we examined interrelations between meal size, growth efficiency and surplus aerobic metabolic capacity (aerobic scope, AS). Large meals required a greater absolute investment of energy to process (a larger so-called specific dynamic action, SDA), but the percentage of digestible meal energy required in the SDA response (SDA coefficient) decreased with increasing meal size. Combined with the findings that growth rate and growth efficiency also increased with food intake, our results demonstrate that it is energetically advantageous for fish to select large prey. However, following a large meal, SDA processes occupied up to 77% of the available AS, indicating that other oxygen-demanding activities like swimming may be compromised while large meals are processed. This trade-off between meal size and AS suggests that fishes like barramundi would benefit from regulating prey size based on imminent requirements and threats.
DOI: 10.6084/m9.figshare.5394652.v1
title: Electronic_supplementary_tables from Into the dark: patterns of middle ear adaptations in subterranean eulipotyphlan mammals

description: Evolution of the middle ear ossicles was a key innovation for mammals, enhancing the transmission of airborne sound. Radiation into various habitats from a terrestrial environment resulted in diversification of the auditory mechanisms among mammals. However, due to the paucity of phylogenetically controlled investigations, how middle ear traits have diversified with functional specialization remains unclear. In order to identify the respective patterns for various lifestyles and to gain insights into fossil forms, we employed a high-resolution tomography technique and compared the middle ear morphology of eulipotyphlan species (moles, shrews and hedgehogs), a group that has radiated into various environments, such as terrestrial, aquatic and subterranean habitats. Three-dimensional geometric morphometric analysis was conducted within a phylogenetically controlled framework. Quantitative shapes were found to strongly reflect the degree of subterranean lifestyle and weakly involve phylogeny. Our analyses demonstrate that subterranean adaptation should include a relatively shorter anterior process of the malleus, an enlarged incus, an enlarged stapes footplate and a reduction of the orbicular apophysis. These traits arguably allow improving low-frequency sound transmission at low frequencies and inhibiting the low-frequency noise which disturbs the subterranean animals to hear airborne sounds.
DOI: 10.6084/m9.figshare.5394631
title: Electronic_supplementary_data_cytb_sequence from Into the dark: patterns of middle ear adaptations in subterranean eulipotyphlan mammals

description: Evolution of the middle ear ossicles was a key innovation for mammals, enhancing the transmission of airborne sound. Radiation into various habitats from a terrestrial environment resulted in diversification of the auditory mechanisms among mammals. However, due to the paucity of phylogenetically controlled investigations, how middle ear traits have diversified with functional specialization remains unclear. In order to identify the respective patterns for various lifestyles and to gain insights into fossil forms, we employed a high-resolution tomography technique and compared the middle ear morphology of eulipotyphlan species (moles, shrews and hedgehogs), a group that has radiated into various environments, such as terrestrial, aquatic and subterranean habitats. Three-dimensional geometric morphometric analysis was conducted within a phylogenetically controlled framework. Quantitative shapes were found to strongly reflect the degree of subterranean lifestyle and weakly involve phylogeny. Our analyses demonstrate that subterranean adaptation should include a relatively shorter anterior process of the malleus, an enlarged incus, an enlarged stapes footplate and a reduction of the orbicular apophysis. These traits arguably allow improving low-frequency sound transmission at low frequencies and inhibiting the low-frequency noise which disturbs the subterranean animals to hear airborne sounds.
DOI: 10.6084/m9.figshare.5394625
title: Supporting data for "Interaction between path integration and visual orientation during the homing run of fiddler crabs"

description: This file contains the raw data (x-y coordinates of true burrows, fake entrances and crabs).