cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.24523336.v1
title: Supplementary Material for: Comparing the effect of pre-biopsy rectal cleaning together with biopsy needle disinfection to each technique alone on hospitalization rates because of post-biopsy infections.

description: Introduction: To compare the effects of three techniques: biopsy needle disinfection with 10% formalin solution, povidone-iodine rectal cleaning, and the use of both methods to decrease hospitalization due to infectious complications after transrectal prostate biopsy. Methods: A total of 827 patients were divided into 3 groups. Group 1 patient data were analyzed retrospectively, while groups 2 and 3 patients were followed up prospectively. Group 1 included 361 patients who underwent biopsy needle disinfection with a 10% formalin solution. Group 2 included 235 patients who underwent biopsy needle disinfection and povidone-iodine rectal cleaning. Group 3 included 231 patients who underwent povidone-iodine rectal cleaning only. The outcome scale was the number of patients hospitalized for biopsy-related infection 30 days after the date of transrectal prostate biopsy. Results: The hospitalization rates due to biopsy-related infectious complications were 3.0%, 0%, and 1.7% in Groups 1, 2, and 3, respectively. The only statistically significant difference was found between Groups 1 and 2. Conclusion: Biopsy needle disinfection and rectal cleaning with povidone-iodine seem to have greater potential to reduce infectious complications when applied together. Further prospective studies are required to confirm these findings.
DOI: 10.5281/zenodo.10213308
title: Auxetic piezoelectric effect in heterostructures
DOI: 10.5281/zenodo.10213309
title: Auxetic piezoelectric effect in heterostructures
DOI: 10.6084/m9.figshare.24121266.v1
title: Elite Universities UK 1922-2022 Complete ver 4

description: Measuring the E, I and XE indices for the universities that educated those people who became cabinet ministers in the UK between 1922 and 2022
DOI: 10.6084/m9.figshare.24458404
title: Supplementary Material for: YTHDC1-modified m6A methylation of hsa_circ_0102678 promotes keratinocyte inflammation induced by Cutibacterium acnes biofilm through regulating miR-146a/TRAF6 and IRAK1 axis

description: Introduction: CircRNAs are closely related to many human diseases, however, their role in acne remains unclear. This study aimed to determine the role of hsa-circ_0102678 in regulating inflammation of acne. Methods: Firstly, microarray analysis was performed to study the expression of circRNAs in acne. Subsequently, RNase R digestion assay and FISH assay were utilized to confirm the characteristics of hsa-circ_0102678. Finally, qRT-PCR, Western blotting analysis, Immunoprecipitation, Luciferase reporter assay, circRNA probe pull-down assay, Biotin-labeled miRNA pull-down assay, RNA immunoprecipitation (RIP) assay and m6A dot blot assay were utilized to reveal the functional roles of hsa-circ_0102678 on inflammation induced by C. acnes biofilm in human primary keratinocytes. Results: Our investigations showed that the expression of hsa-circ_0102678 was significantly decreased in acne tissues and hsa-circ_0102678 was a type of circRNAs, which was mainly localized in the cytoplasm of primary human keratinocytes. Moreover, hsa-circ_0102678 remarkably affected the expression of IL-8, IL-6, and TNF-α, which induced by C. acnes biofilm. Importantly, mechanistic studies indicated that the YTHDC1 could bind directly to hsa-circ_0102678 and promote the export of N6-methyladenosine modified hsa-circ_0102678 to the cytoplasm. Besides, hsa-circ_0102678 could bind to miR-146a and sponge miR-146a to promote the expression of IRAK1 and TRAF6. Conclusion: Our findings revealed a previously unknown process by which hsa_circ_0102678 promoted keratinocyte inflammation induced by C. acnes biofilm via regulating miR-146a/TRAF6 and IRAK1 axis.
DOI: 10.6084/m9.figshare.24458404.v1
title: Supplementary Material for: YTHDC1-modified m6A methylation of hsa_circ_0102678 promotes keratinocyte inflammation induced by Cutibacterium acnes biofilm through regulating miR-146a/TRAF6 and IRAK1 axis

description: Introduction: CircRNAs are closely related to many human diseases, however, their role in acne remains unclear. This study aimed to determine the role of hsa-circ_0102678 in regulating inflammation of acne. Methods: Firstly, microarray analysis was performed to study the expression of circRNAs in acne. Subsequently, RNase R digestion assay and FISH assay were utilized to confirm the characteristics of hsa-circ_0102678. Finally, qRT-PCR, Western blotting analysis, Immunoprecipitation, Luciferase reporter assay, circRNA probe pull-down assay, Biotin-labeled miRNA pull-down assay, RNA immunoprecipitation (RIP) assay and m6A dot blot assay were utilized to reveal the functional roles of hsa-circ_0102678 on inflammation induced by C. acnes biofilm in human primary keratinocytes. Results: Our investigations showed that the expression of hsa-circ_0102678 was significantly decreased in acne tissues and hsa-circ_0102678 was a type of circRNAs, which was mainly localized in the cytoplasm of primary human keratinocytes. Moreover, hsa-circ_0102678 remarkably affected the expression of IL-8, IL-6, and TNF-α, which induced by C. acnes biofilm. Importantly, mechanistic studies indicated that the YTHDC1 could bind directly to hsa-circ_0102678 and promote the export of N6-methyladenosine modified hsa-circ_0102678 to the cytoplasm. Besides, hsa-circ_0102678 could bind to miR-146a and sponge miR-146a to promote the expression of IRAK1 and TRAF6. Conclusion: Our findings revealed a previously unknown process by which hsa_circ_0102678 promoted keratinocyte inflammation induced by C. acnes biofilm via regulating miR-146a/TRAF6 and IRAK1 axis.
DOI: 10.6084/m9.figshare.24648705
title: MaxEnt model and Meta-analytic raw data

description: MaxEnt model and Meta-analytic raw data
DOI: 10.6084/m9.figshare.24648705.v1
title: MaxEnt model and Meta-analytic raw data

description: MaxEnt model and Meta-analytic raw data
DOI: 10.5281/zenodo.7624092
title: Microfluidic Giant Polymer Vesicles Equipped with Biopores for High-Throughput Screening of Bacteria

description: Understanding the mechanisms of antibiotic resistance is critical for the development of new therapeutics. Traditional methods for testing bacteria are often limited in their efficiency and reusability. Single bacterial cells can be studied at high throughput using double emulsions, although the lack of control over the oil shell permeability and limited access to the droplet interior present serious drawbacks. Here, a straightforward strategy for studying bacteria-encapsulating double emulsion-templated giant unilamellar vesicles (GUVs) is introduced. This microfluidic approach serves to simultaneously load bacteria inside synthetic GUVs and to permeabilize their membrane with the pore-forming peptide melittin. This enables antibiotic delivery or the influx of fresh medium into the GUV lumen for highly parallel cultivation and antimicrobial efficacy testing. Polymer-based GUVs proved to be efficient culture and analysis microvessels, as microfluidics allow easy selection and encapsulation of bacteria and rapid modification of culture conditions for antibiotic development. Further, a method for in situ profiling of biofilms within GUVs for high-throughput screening is demonstrated. Conceivably, synthetic GUVs equipped with biopores can serve as a foundation for the high-throughput screening of bacterial colony interactions during biofilm formation and for investigating the effect of antibiotics on biofilms.
DOI: 10.5281/zenodo.7624093
title: Microfluidic Giant Polymer Vesicles Equipped with Biopores for High-Throughput Screening of Bacteria

description: Understanding the mechanisms of antibiotic resistance is critical for the development of new therapeutics. Traditional methods for testing bacteria are often limited in their efficiency and reusability. Single bacterial cells can be studied at high throughput using double emulsions, although the lack of control over the oil shell permeability and limited access to the droplet interior present serious drawbacks. Here, a straightforward strategy for studying bacteria-encapsulating double emulsion-templated giant unilamellar vesicles (GUVs) is introduced. This microfluidic approach serves to simultaneously load bacteria inside synthetic GUVs and to permeabilize their membrane with the pore-forming peptide melittin. This enables antibiotic delivery or the influx of fresh medium into the GUV lumen for highly parallel cultivation and antimicrobial efficacy testing. Polymer-based GUVs proved to be efficient culture and analysis microvessels, as microfluidics allow easy selection and encapsulation of bacteria and rapid modification of culture conditions for antibiotic development. Further, a method for in situ profiling of biofilms within GUVs for high-throughput screening is demonstrated. Conceivably, synthetic GUVs equipped with biopores can serve as a foundation for the high-throughput screening of bacterial colony interactions during biofilm formation and for investigating the effect of antibiotics on biofilms.
DOI: 10.3217/8rxt9-jy433
title: Anthracene XRD Data

description: This data set contains GIXD (grazing incidence x-ray diffraction) data of different anthracene samples measured at the XRD1 beamline Elettra Trieste. The samples are anthracene powder and anthracene thin films with uniplanar and biaxial texture. Furthermore, a specular scan of an anthracene thin film with uniplanar texture is included, measured on a Panalytical Epyrean. 
description: GIXD data was measured with X-rays with wavelength 1.4 A on a Dectris Pilatis 2M detector at a sample-detector-distance of 200 mm. For the transformation of the data to reciprocal space an LaB6 calibrant was measured. The corresponding file is also included in the data set.
DOI: 10.6084/m9.figshare.24525040
title: Supplementary Material for: Associations of atopic dermatitis with attention deficit/hyperactivity disorder and autism spectrum disorder: a systematic review and meta-analysis

description: Background: Atopic dermatitis (AD) shares similarities with attention deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) regarding pathogenesis involving inflammation and genetics. Nevertheless, evidence on the associations of AD with ADHD and/or ASD is inconclusive. This study aimed to systematically examine the existing evidence on the associations between AD, ADHD, and ASD. Methods: The Meta-analysis of Observational Studies in Epidemiology guideline was followed. We searched MEDLINE, Embase, Cochrane Library, and Web of Science databases from their respective inceptions through February 4, 2022. Observational studies providing adjusted estimates and/or prevalences for ADHD and ASD in patients with AD were enrolled. A random-effects model meta-analysis was conducted to calculate pooled odds ratios (ORs) and confidence intervals (CIs). Subgroup analyses according to AD severity, age, geographic location, and study design were performed. Results: Overall, a total of 24 studies with 71,373,639 subjects were enrolled. Our meta-analysis demonstrated significant associations of AD with ADHD (pooled OR, 1.28; 95% CI, 1.18–1.40) and ASD (pooled OR, 1.87; 95% CI, 1.30–2.68). Subgroup analyses revealed that the associations for ADHD were most prominent in studies evaluating severe AD patients as well as in studies focusing on school-age children and adolescents. Among patients with AD, the pooled prevalence of ADHD was 6.6% and the respective prevalence of ASD was 1.6%. Conclusion: The evidence to date suggests significant associations of AD with ADHD and ASD. Psychiatric consultation and an interdisciplinary approach would benefit patients with AD presented with behavioral symptoms suggestive of ADHD or ASD.
DOI: 10.6084/m9.figshare.24525040.v1
title: Supplementary Material for: Associations of atopic dermatitis with attention deficit/hyperactivity disorder and autism spectrum disorder: a systematic review and meta-analysis

description: Background: Atopic dermatitis (AD) shares similarities with attention deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) regarding pathogenesis involving inflammation and genetics. Nevertheless, evidence on the associations of AD with ADHD and/or ASD is inconclusive. This study aimed to systematically examine the existing evidence on the associations between AD, ADHD, and ASD. Methods: The Meta-analysis of Observational Studies in Epidemiology guideline was followed. We searched MEDLINE, Embase, Cochrane Library, and Web of Science databases from their respective inceptions through February 4, 2022. Observational studies providing adjusted estimates and/or prevalences for ADHD and ASD in patients with AD were enrolled. A random-effects model meta-analysis was conducted to calculate pooled odds ratios (ORs) and confidence intervals (CIs). Subgroup analyses according to AD severity, age, geographic location, and study design were performed. Results: Overall, a total of 24 studies with 71,373,639 subjects were enrolled. Our meta-analysis demonstrated significant associations of AD with ADHD (pooled OR, 1.28; 95% CI, 1.18–1.40) and ASD (pooled OR, 1.87; 95% CI, 1.30–2.68). Subgroup analyses revealed that the associations for ADHD were most prominent in studies evaluating severe AD patients as well as in studies focusing on school-age children and adolescents. Among patients with AD, the pooled prevalence of ADHD was 6.6% and the respective prevalence of ASD was 1.6%. Conclusion: The evidence to date suggests significant associations of AD with ADHD and ASD. Psychiatric consultation and an interdisciplinary approach would benefit patients with AD presented with behavioral symptoms suggestive of ADHD or ASD.
DOI: 10.6084/m9.figshare.24493498
title: Supplementary Material for: Predictions of Serum Phosphate Concentration During CRRT Using a Steady State Mass Balance Model

description: Introduction: Hypophosphatemia is common during continuous renal replacement therapy (CRRT), but serum phosphate levels can potentially be maintained during treatment by either intravenous phosphate supplementation or addition of phosphate to renal replacement therapy (RRT) solutions. Methods: We developed a steady state phosphate mass balance model to assess the effects of CRRT dose on serum phosphate concentration when using both phosphate-free and phosphate-containing RRT solutions, with emphasis on low CRRT doses. Results: The model predicted that measurements of serum phosphate concentration prior to (initial) and during CRRT (final) together with clinical data on CRRT dose, treatment duration and phosphate supplementation can determine model patient parameters, that is, both the initial generation rate and clearance of phosphate prior to CRRT. Model parameters were then calculated from average patient data reported in several previous publications with a standard or high CRRT dose. Using representative model parameters for typical patients, predictions were then made of the effect of low CRRT dose on the change in serum phosphate levels after implementation of CRRT. The model predicted that CRRT at a low dose using phosphate-free RRT solutions will limit, but not eliminate, the incidence of hypophosphatemia. Further, the model predicted that CRRT at a low dose will have virtually no influence on the incidence of hyperphosphatemia when using phosphate-containing RRT solutions. Conclusions: This report identifies the clinical measurements for using the proposed model for individualizing the CRRT dose and RRT phosphate concentration to maintain serum phosphate concentrations in a desired range.
DOI: 10.6084/m9.figshare.24493498.v1
title: Supplementary Material for: Predictions of Serum Phosphate Concentration During CRRT Using a Steady State Mass Balance Model

description: Introduction: Hypophosphatemia is common during continuous renal replacement therapy (CRRT), but serum phosphate levels can potentially be maintained during treatment by either intravenous phosphate supplementation or addition of phosphate to renal replacement therapy (RRT) solutions. Methods: We developed a steady state phosphate mass balance model to assess the effects of CRRT dose on serum phosphate concentration when using both phosphate-free and phosphate-containing RRT solutions, with emphasis on low CRRT doses. Results: The model predicted that measurements of serum phosphate concentration prior to (initial) and during CRRT (final) together with clinical data on CRRT dose, treatment duration and phosphate supplementation can determine model patient parameters, that is, both the initial generation rate and clearance of phosphate prior to CRRT. Model parameters were then calculated from average patient data reported in several previous publications with a standard or high CRRT dose. Using representative model parameters for typical patients, predictions were then made of the effect of low CRRT dose on the change in serum phosphate levels after implementation of CRRT. The model predicted that CRRT at a low dose using phosphate-free RRT solutions will limit, but not eliminate, the incidence of hypophosphatemia. Further, the model predicted that CRRT at a low dose will have virtually no influence on the incidence of hyperphosphatemia when using phosphate-containing RRT solutions. Conclusions: This report identifies the clinical measurements for using the proposed model for individualizing the CRRT dose and RRT phosphate concentration to maintain serum phosphate concentrations in a desired range.
DOI: 10.17909/1r25-qb27
title: iue SPECTRA hd 143699
DOI: 10.20387/bonares-evm2-pzae
title: Test data FAIRagro Guest

description: Dataset for data publication demonstration during the visit of FAIRagro guest on November 28th, 2023

Research domain: Other

Research question: How are datasets published in the BonaRes Repository?
DOI: 10.6084/m9.figshare.24476599
title: Supplementary Material for: Convergent anuran middle ear loss lacks a universal, adaptive explanation

description: Shared selection pressures often explain convergent trait loss, yet anurans (frogs and toads) have lost their middle ears at least 38 times with no obvious shared selection pressures unifying ‘earless’ taxa. Anuran tympanic middle ear loss is especially perplexing because acoustic communication is dominant within Anura and tympanic middle ears enhance airborne hearing in most tetrapods. Here we examine whether particular geographic ranges, microhabitats, activity patterns, or aspects of acoustic communication are associated with anuran tympanic middle ear loss. Although we find modest differences between the geographic ranges of eared and earless species and increased diurnality in earless species, we find no universal adaptive explanation for the many instances of anuran tympanic middle ear loss. The puzzling lack of shared selection pressures motivates discussion of alternative hypotheses, including genetic or developmental constraints, and the possibility that tympanic middle ear loss is maladaptive.
DOI: 10.6084/m9.figshare.24476599.v1
title: Supplementary Material for: Convergent anuran middle ear loss lacks a universal, adaptive explanation

description: Shared selection pressures often explain convergent trait loss, yet anurans (frogs and toads) have lost their middle ears at least 38 times with no obvious shared selection pressures unifying ‘earless’ taxa. Anuran tympanic middle ear loss is especially perplexing because acoustic communication is dominant within Anura and tympanic middle ears enhance airborne hearing in most tetrapods. Here we examine whether particular geographic ranges, microhabitats, activity patterns, or aspects of acoustic communication are associated with anuran tympanic middle ear loss. Although we find modest differences between the geographic ranges of eared and earless species and increased diurnality in earless species, we find no universal adaptive explanation for the many instances of anuran tympanic middle ear loss. The puzzling lack of shared selection pressures motivates discussion of alternative hypotheses, including genetic or developmental constraints, and the possibility that tympanic middle ear loss is maladaptive.
DOI: 10.6084/m9.figshare.24648747
title: Data.xlsx

description: Experimental datasheet for manuscript named"<i>Gut-derived Memory γδ T17 Cells Exacerbate Sepsis-induced Acute Lung Injury</i>".
DOI: 10.6084/m9.figshare.24648747.v1
title: Data.xlsx

description: Experimental datasheet for manuscript named"<i>Gut-derived Memory γδ T17 Cells Exacerbate Sepsis-induced Acute Lung Injury</i>".
DOI: 10.6084/m9.figshare.24646212
title: A high-resolution lake-catchment dataset for the Tibet endorheic basin

description: we introduce a lake-oriented catchment delineation method based on the latest Forest and Buildings removed Copernicus DEM(FABDEM). This method encompasses four steps: lowering of water pixel elevation, calculation of flow direction, delineation of lake catchment, and delineation of whole catchment. Furthermore, this approach facilitates the differentiation of lake types and the identification of hydrological connectivity pathways between lakes. Compared to other studies, our method takes into account the complex terrain of endorheic zones and offers more precise results in data processing and catchment area delineation. Utilizing 2018 data for lakes larger than 1 km² on the Qiangtang Plateau (QP), we delineated 1003 lake catchments. Following the analysis of hydrological connectivity, 518 whole catchments were identified, of which 345 had no upstream lake.
DOI: 10.6084/m9.figshare.24646212.v1
title: A high-resolution lake-catchment dataset for the Tibet endorheic basin

description: we introduce a lake-oriented catchment delineation method based on the latest Forest and Buildings removed Copernicus DEM(FABDEM). This method encompasses four steps: lowering of water pixel elevation, calculation of flow direction, delineation of lake catchment, and delineation of whole catchment. Furthermore, this approach facilitates the differentiation of lake types and the identification of hydrological connectivity pathways between lakes. Compared to other studies, our method takes into account the complex terrain of endorheic zones and offers more precise results in data processing and catchment area delineation. Utilizing 2018 data for lakes larger than 1 km² on the Qiangtang Plateau (QP), we delineated 1003 lake catchments. Following the analysis of hydrological connectivity, 518 whole catchments were identified, of which 345 had no upstream lake.
DOI: 10.48677/37d564f9-5d63-4760-aae6-29d3f98ee1b4
title: Adressregister tagesaktuell

description: Das österreichische Adressregister ist der amtliche offizielle Adressdatenbestand Österreichs, welcher laufend von den zuständigen Gemeinden und Städten auf Basis länderspezifischer gesetzlicher Grundlagen geführt und vom BEV - Bundesamt für Eich und Vermessungswesen in verschiedenen Ausprägungen abgegeben wird. Jede Adresse hat zusätzlich zu vielen weiteren Informationen eine exakte koordinative Zuordnung (Geocodierung).
DOI: 10.6084/m9.figshare.24639192
title: Data of Type 2 DM Patients in Primary Health Care

description: The following data are demographic and examination data for Type 2 DM patients. Laboratory results include BGL, HbA1B, total cholesterol, HDL, and LDL triglycerides. Then the results of the Nitric oxide (NO) and VEGF examinations
DOI: 10.6084/m9.figshare.24639192.v1
title: Data of Type 2 DM Patients in Primary Health Care

description: The following data are demographic and examination data for Type 2 DM patients. Laboratory results include BGL, HbA1B, total cholesterol, HDL, and LDL triglycerides. Then the results of the Nitric oxide (NO) and VEGF examinations