cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.1291628
title: Swansea University APC Data 2014

description: This dataset provides a record of publications that have been funded from the RCUK Gold Open Access block grant received by Swansea University for the calendar year 2014. Sheet 1 - Data for the period January – July 2014 previously released on Figshare as part of the 2013-14 data Sheet 2 - Period August – December 2014 (new data) Sheet 3 - Contact information Released with the permission of Swansea University, Information Services & Systems (ISS).
DOI: 10.6084/m9.figshare.1291630.v1
title: Nitrogen doped graphene nanosheet supported platinum nanoparticles as high performance electrochemical homocysteine biosensors

description: Functional carbon nanomaterials are significantly important for the development of high performance<br>sensitive and selective electrochemical biosensors. In this study, graphene supported platinum<br>nanoparticles (GN–PtNPs) and nitrogen doped graphene supported platinum nanoparticles (N-GN–<br>PtNPs) were synthesized by a simple chemical reduction method and explored as high performance<br>nanocatalyst supports, as well as doped nanocatalyst supports, toward electrochemical oxidation of<br>homocysteine (HCY) for the first the time. Our studies demonstrate that N-doped graphene supported<br>PtNPs show higher electrocatalytic activity for HCY with an experimental detection limit of 200 pM.<br>Moreover, N-doped graphene supported Pt was demonstrated to have excellent selectivity in the<br>electrochemical oxidation of HCY i.e., the detection of HCY is successful in the presence of a 20-fold<br>excess of ascorbic acid (AA). The practical application of N-doped graphene supported PtNP materials is<br>effectively shown for the determination of HCY in both human blood serum and urine samples, by<br>differential pulse voltammetry under optimized conditions. Our findings conclude that N-doped<br>graphene supported PtNPs can be developed as a high performance and versatile nano-electrocatalyst<br>for electrochemical biosensor applications.
DOI: 10.6084/m9.figshare.1291646.v1
title: CGN tomato passport data

description: The passport data from CGN for their genebank (germline/seed) collections of Tomato
DOI: 10.6084/m9.figshare.1291648.v1
title: Gaussian Job Archive for C13H16LiN3O4

description: Archive of work produced using the resources of the Imperial College High Performance Computing Service.
DOI: 10.6084/m9.figshare.1291627
title: Tungsten Carbide Nanotubes Supported Platinum Nanoparticles as a Potential Sensing Platform for Oxalic Acid

description: Supported tungsten carbide is an efficient and<br>vital nanomaterial for the development of high-performance,<br>sensitive, and selective electrochemical sensors. In this work,<br>tungsten carbide with tube-like nanostructures (WC NTs)<br>supported platinum nanoparticles (PtNPs) are synthesized and<br>explored as an efficient catalyst toward electrochemical<br>oxidation of oxalic acid for the first the time. The WC NTs<br>supported PtNPs modified glassy carbon (GC) electrode is<br>highly sensitive toward the electrochemical oxidation of oxalic<br>acid. A large decrease in the oxidation overpotential (220 mV)<br>and significant enhancement in the peak current compared to<br>unmodified and Pt/C modified GC electrodes have been<br>observed without using any redox mediator. Moreover, WC NTs supported PtNPs modified electrode possessed wide linear<br>concentration ranges from 0 to 125 nM and a higher sensitivity toward the oxidation of oxalic acid (80 nA/nM) achieved by the<br>amperometry method. The present modified electrode showed an experimentally determined lowest detection limit (LOD) of 12<br>nM (S/N = 3). Further, WC NTs supported PtNPs electrode can be demonstrated to have an excellent selectivity toward the<br>detection of oxalic acid in the presence of a 200-fold excess of major important interferents. The practical application of WC NTs<br>supported PtNPs has also been demonstrated in the detection of oxalic acid in tomato fruit sample, by differential pulse<br>voltammetry under optimized conditions.
DOI: 10.6084/m9.figshare.1291626
title: Spinel-type lithium cobalt oxide as a bifunctional electrocatalyst for the oxygen evolution and oxygen reduction reactions

description: Development of efficient, affordable electrocatalysts for the oxygen evolution reaction and<br>the oxygen reduction reaction is critical for rechargeable metal-air batteries. Here we present<br>lithium cobalt oxide, synthesized at 400 C (designated as LT-LiCoO2) that adopts a lithiated<br>spinel structure, as an inexpensive, efficient electrocatalyst for the oxygen evolution reaction.<br>The catalytic activity of LT-LiCoO2 is higher than that of both spinel cobalt oxide and layered<br>lithium cobalt oxide synthesized at 800 C (designated as HT-LiCoO2) for the oxygen evolution<br>reaction. Although LT-LiCoO2 exhibits poor activity for the oxygen reduction reaction,<br>the chemically delithiated LT-Li1 xCoO2 samples exhibit a combination of high oxygen<br>reduction reaction and oxygen evolution reaction activities, making the spinel-type LTLi0,5CoO2<br>a potential bifunctional electrocatalyst for rechargeable metal-air batteries. The<br>high activities of these delithiated compositions are attributed to the Co4O4 cubane subunits<br>and a pinning of the Co3 þ /4 þ :3d energy with the top of the O2 :2p band.<br>DO
DOI: 10.6084/m9.figshare.1291628.v1
title: Swansea University APC Data 2014

description: This dataset provides a record of publications that have been funded from the RCUK Gold Open Access block grant received by Swansea University for the calendar year 2014. Sheet 1 - Data for the period January – July 2014 previously released on Figshare as part of the 2013-14 data Sheet 2 - Period August – December 2014 (new data) Sheet 3 - Contact information Released with the permission of Swansea University, Information Services & Systems (ISS).
DOI: 10.6084/m9.figshare.1291623
title: Facile and rapid synthesis of Pd nanodendrites for electrocatalysis and surface-enhanced Raman scattering applications

description: Numerous properties from metal nanostructures can be tuned by controlling both their size and shape. In<br>particular, the latter is extremely important because the type of crystalline surface affects the surface<br>electronic density. This paper describes a simple approach to the synthesis of highly-structured,<br>anisotropic palladium nanostructured dendrites. They were obtained using an eco-friendly biomolecule<br>5-hydroxytryptophan, which acts as both a reducing and stabilizing agent. The growth mechanism is<br>proposed for the evolution of dendrites morphology. It was found that the concentration of 5-<br>hydroxytryptophan played a vital role on the morphology of the nanostructured Pd dendrites. This<br>nanomaterial shows enhanced electrocatalytic performance towards the oxidation of formic acid, and it<br>exhibits surface-enhanced Raman scattering properties towards the prostate specific antigen. These<br>properties may be explored in fuel cells and biosensors, respectively
DOI: 10.6084/m9.figshare.1291624
title: Gaussian Job Archive for C13H15BeN3O3

description: Archive of work produced using the resources of the Imperial College High Performance Computing Service.
DOI: 10.6084/m9.figshare.1291625
title: Three-dimensional cubic ordered mesoporous carbon (CMK-8) as highly efficient stable Pd electro-catalyst support for formic acid oxidation

description: In this work, Pd nanoparticles were supported on two types of three-dimensional cubic highly ordered<br>mesoporous carbon (CMK-8) by the sodium borohydride reduction method and the activity of the Pd/<br>CMK-8 electro-catalysts towards formic acid oxidation was evaluated and compared with that of<br>commercial Pd/C (E-TEK) catalyst. The catalysts were characterized by transmission electron microscopy<br>(TEM), X-ray diffraction (XRD), cyclic voltammetry, and chronoamperometry. Cyclic voltammetry<br>revealed Pd/CMK-8 with larger pores as being the most electroactive with a mass specific activity<br>(mA mgPd<br> 1) of 486.4 that exceeded not only that of the Pd/C (E-TEK) (386.5 mAmgPd<br> 1) but also that of<br>recently reported Pd/CNT (200 mAmgPd<br> 1), Pd/Graphene (210mAmgPd<br> 1) and Pd/Vulcan XC 72 (193mAmgPd<br> 1).<br>As demonstrated with chronoamperometry, the larger pore Pd/CMK-8 also proved to be the most stable<br>catalyst. This exceptional performance can be ascribed to the very high surface area and Ia3d symmetry<br>that yields a relatively isotropic graphitized structure with a high conductivity. In addition, the open<br>framework of the 3-D bicontinous channels and highly ordered mesopores allows for an advanced mass<br>transfer characteristics. The results show that CMK-8 support would significantly improve the power<br>output and stability of Pd-based electro-catalysts for formic acid oxidation.
DOI: 10.6084/m9.figshare.1291627.v1
title: Tungsten Carbide Nanotubes Supported Platinum Nanoparticles as a Potential Sensing Platform for Oxalic Acid

description: Supported tungsten carbide is an efficient and<br>vital nanomaterial for the development of high-performance,<br>sensitive, and selective electrochemical sensors. In this work,<br>tungsten carbide with tube-like nanostructures (WC NTs)<br>supported platinum nanoparticles (PtNPs) are synthesized and<br>explored as an efficient catalyst toward electrochemical<br>oxidation of oxalic acid for the first the time. The WC NTs<br>supported PtNPs modified glassy carbon (GC) electrode is<br>highly sensitive toward the electrochemical oxidation of oxalic<br>acid. A large decrease in the oxidation overpotential (220 mV)<br>and significant enhancement in the peak current compared to<br>unmodified and Pt/C modified GC electrodes have been<br>observed without using any redox mediator. Moreover, WC NTs supported PtNPs modified electrode possessed wide linear<br>concentration ranges from 0 to 125 nM and a higher sensitivity toward the oxidation of oxalic acid (80 nA/nM) achieved by the<br>amperometry method. The present modified electrode showed an experimentally determined lowest detection limit (LOD) of 12<br>nM (S/N = 3). Further, WC NTs supported PtNPs electrode can be demonstrated to have an excellent selectivity toward the<br>detection of oxalic acid in the presence of a 200-fold excess of major important interferents. The practical application of WC NTs<br>supported PtNPs has also been demonstrated in the detection of oxalic acid in tomato fruit sample, by differential pulse<br>voltammetry under optimized conditions.
DOI: 10.6084/m9.figshare.1291625.v1
title: Three-dimensional cubic ordered mesoporous carbon (CMK-8) as highly efficient stable Pd electro-catalyst support for formic acid oxidation

description: In this work, Pd nanoparticles were supported on two types of three-dimensional cubic highly ordered<br>mesoporous carbon (CMK-8) by the sodium borohydride reduction method and the activity of the Pd/<br>CMK-8 electro-catalysts towards formic acid oxidation was evaluated and compared with that of<br>commercial Pd/C (E-TEK) catalyst. The catalysts were characterized by transmission electron microscopy<br>(TEM), X-ray diffraction (XRD), cyclic voltammetry, and chronoamperometry. Cyclic voltammetry<br>revealed Pd/CMK-8 with larger pores as being the most electroactive with a mass specific activity<br>(mA mgPd<br> 1) of 486.4 that exceeded not only that of the Pd/C (E-TEK) (386.5 mAmgPd<br> 1) but also that of<br>recently reported Pd/CNT (200 mAmgPd<br> 1), Pd/Graphene (210mAmgPd<br> 1) and Pd/Vulcan XC 72 (193mAmgPd<br> 1).<br>As demonstrated with chronoamperometry, the larger pore Pd/CMK-8 also proved to be the most stable<br>catalyst. This exceptional performance can be ascribed to the very high surface area and Ia3d symmetry<br>that yields a relatively isotropic graphitized structure with a high conductivity. In addition, the open<br>framework of the 3-D bicontinous channels and highly ordered mesopores allows for an advanced mass<br>transfer characteristics. The results show that CMK-8 support would significantly improve the power<br>output and stability of Pd-based electro-catalysts for formic acid oxidation.
DOI: 10.6084/m9.figshare.1291622
title: Gaussian Job Archive for C13H14N3NaO3

description: Archive of work produced using the resources of the Imperial College High Performance Computing Service.
DOI: 10.6084/m9.figshare.1291624.v1
title: Gaussian Job Archive for C13H15BeN3O3

description: Archive of work produced using the resources of the Imperial College High Performance Computing Service.
DOI: 10.6084/m9.figshare.1291622.v1
title: Gaussian Job Archive for C13H14N3NaO3

description: Archive of work produced using the resources of the Imperial College High Performance Computing Service.
DOI: 10.6084/m9.figshare.1291523
title: Habitat suitability curves for benthic macroinvertebrates from a small New Zealand river

description: We developed habitat suitability curves (HSC) using generalised additive models (GAMs) for nine benthic macroinvertebrate taxa from a small New Zealand river for hydraulic-habitat modelling assessments of instream flow requirements. We included interaction terms between the primary variables (water depth, velocity, substrate) when significant, to address a longstanding criticism of univariate HSC. To date, only large-river univariate HSC have been available and these have been used in hydraulic-habitat applications on small rivers, despite doubt over the transferability of HSC between rivers of different size and type. We tested the outcome on the predicted abundance–flow relationship of applying the small-river habitat suitability GAMs versus large-river GAMs for two taxa on the same small river. We found the effects of flow allocation were overestimated by the large-river GAMs relative to the small-river GAMs. Further research to develop general HSC for categories of river size and type is needed to better inform hydraulic-habitat modelling applications.
DOI: 10.6084/m9.figshare.1291523.v2
title: Habitat suitability curves for benthic macroinvertebrates from a small New Zealand river

description: We developed habitat suitability curves (HSC) using generalised additive models (GAMs) for nine benthic macroinvertebrate taxa from a small New Zealand river for hydraulic-habitat modelling assessments of instream flow requirements. We included interaction terms between the primary variables (water depth, velocity, substrate) when significant, to address a longstanding criticism of univariate HSC. To date, only large-river univariate HSC have been available and these have been used in hydraulic-habitat applications on small rivers, despite doubt over the transferability of HSC between rivers of different size and type. We tested the outcome on the predicted abundance–flow relationship of applying the small-river habitat suitability GAMs versus large-river GAMs for two taxa on the same small river. We found the effects of flow allocation were overestimated by the large-river GAMs relative to the small-river GAMs. Further research to develop general HSC for categories of river size and type is needed to better inform hydraulic-habitat modelling applications.
DOI: 10.6084/m9.figshare.1291523.v1
title: Habitat suitability curves for benthic macroinvertebrates from a small New Zealand river

description: We developed habitat suitability curves (HSC) using generalised additive models (GAMs) for nine benthic macroinvertebrate taxa from a small New Zealand river for hydraulic-habitat modelling assessments of instream flow requirements. We included interaction terms between the primary variables (water depth, velocity, substrate) when significant, to address a longstanding criticism of univariate HSC. To date, only large-river univariate HSC have been available and these have been used in hydraulic-habitat applications on small rivers, despite doubt over the transferability of HSC between rivers of different size and type. We tested the outcome on the predicted abundance–flow relationship of applying the small-river habitat suitability GAMs versus large-river GAMs for two taxa on the same small river. We found the effects of flow allocation were overestimated by the large-river GAMs relative to the small-river GAMs. Further research to develop general HSC for categories of river size and type is needed to better inform hydraulic-habitat modelling applications.
DOI: 10.6084/m9.figshare.1291209
title: Lyons et al. 2014 Ecological Applications #:#, #-#

description: Data used in analysis in Lyons et al. 2014. Predator identity influences the effect of habitat management on nest predation. <em>Ecological Applications</em> (Accepted)
DOI: 10.6084/m9.figshare.1291209.v1
title: Lyons et al. 2014 Ecological Applications #:#, #-#

description: Data used in analysis in Lyons et al. 2014. Predator identity influences the effect of habitat management on nest predation. <em>Ecological Applications</em> (Accepted)
DOI: 10.6084/m9.figshare.1291200
title: CDC28 phosphorylates Cac1p and regulates the association of chromatin assembly factor i with chromatin

description: Chromatin Assembly Factor I (CAF-I) plays a key role in the replication-coupled assembly of nucleosomes. It is expected that its function is linked to the regulation of the cell cycle, but little detail is available. Current models suggest that CAF-I is recruited to replication forks and to chromatin via an interaction between its Cac1p subunit and the replication sliding clamp, PCNA, and that this interaction is stimulated by the kinase <i>CDC7</i>. Here we show that another kinase, <i>CDC28</i>, phosphorylates Cac1p on serines 94 and 515 in early S phase and regulates its association with chromatin, but not its association with PCNA. Mutations in the Cac1p-phosphorylation sites of <i>CDC28</i> but not of <i>CDC7</i> substantially reduce the <i>in vivo</i> phosphorylation of Cac1p. However, mutations in the putative <i>CDC7</i> target sites on Cac1p reduce its stability. The association of CAF-I with chromatin is impaired in a <i>cdc28–1</i> mutant and to a lesser extent in a <i>cdc7–1</i> mutant. In addition, mutations in the Cac1p-phosphorylation sites by both <i>CDC28</i> and <i>CDC7</i> reduce gene silencing at the telomeres. We propose that this phosphorylation represents a regulatory step in the recruitment of CAF-I to chromatin in early S phase that is distinct from the association of CAF-I with PCNA. Hence, we implicate <i>CDC28</i> in the regulation of chromatin reassembly during DNA replication. These findings provide novel mechanistic insights on the links between cell-cycle regulation, DNA replication and chromatin reassembly.
DOI: 10.6084/m9.figshare.1291199
title: Metabolic reprogramming orchestrates cancer stem cell properties in nasopharyngeal carcinoma

description: Cancer stem cells (CSCs) represent a subpopulation of tumor cells endowed with self-renewal capacity and are considered as an underlying cause of tumor recurrence and metastasis. The metabolic signatures of CSCs and the mechanisms involved in the regulation of their stem cell-like properties still remain elusive. We utilized nasopharyngeal carcinoma (NPC) CSCs as a model to dissect their metabolic signatures and found that CSCs underwent metabolic shift and mitochondrial resetting distinguished from their differentiated counterparts. In metabolic shift, CSCs showed a greater reliance on glycolysis for energy supply compared with the parental cells. In mitochondrial resetting, the quantity and function of mitochondria of CSCs were modulated by the biogenesis of the organelles, and the round-shaped mitochondria were distributed in a peri-nuclear manner similar to those seen in the stem cells. In addition, we blocked the glycolytic pathway, increased the ROS levels, and depolarized mitochondrial membranes of CSCs, respectively, and examined the effects of these metabolic factors on CSC properties. Intriguingly, the properties of CSCs were curbed when we redirected the quintessential metabolic reprogramming, which indicates that the plasticity of energy metabolism regulated the balance between acquisition and loss of the stemness status. Taken together, we suggest that metabolic reprogramming is critical for CSCs to sustain self-renewal, deter from differentiation and enhance the antioxidant defense mechanism. Characterization of metabolic reprogramming governing CSC properties is paramount to the design of novel therapeutic strategies through metabolic intervention of CSCs.
DOI: 10.6084/m9.figshare.1291200.v1
title: CDC28 phosphorylates Cac1p and regulates the association of chromatin assembly factor i with chromatin

description: Chromatin Assembly Factor I (CAF-I) plays a key role in the replication-coupled assembly of nucleosomes. It is expected that its function is linked to the regulation of the cell cycle, but little detail is available. Current models suggest that CAF-I is recruited to replication forks and to chromatin via an interaction between its Cac1p subunit and the replication sliding clamp, PCNA, and that this interaction is stimulated by the kinase <i>CDC7</i>. Here we show that another kinase, <i>CDC28</i>, phosphorylates Cac1p on serines 94 and 515 in early S phase and regulates its association with chromatin, but not its association with PCNA. Mutations in the Cac1p-phosphorylation sites of <i>CDC28</i> but not of <i>CDC7</i> substantially reduce the <i>in vivo</i> phosphorylation of Cac1p. However, mutations in the putative <i>CDC7</i> target sites on Cac1p reduce its stability. The association of CAF-I with chromatin is impaired in a <i>cdc28–1</i> mutant and to a lesser extent in a <i>cdc7–1</i> mutant. In addition, mutations in the Cac1p-phosphorylation sites by both <i>CDC28</i> and <i>CDC7</i> reduce gene silencing at the telomeres. We propose that this phosphorylation represents a regulatory step in the recruitment of CAF-I to chromatin in early S phase that is distinct from the association of CAF-I with PCNA. Hence, we implicate <i>CDC28</i> in the regulation of chromatin reassembly during DNA replication. These findings provide novel mechanistic insights on the links between cell-cycle regulation, DNA replication and chromatin reassembly.
DOI: 10.6084/m9.figshare.1291199.v1
title: Metabolic reprogramming orchestrates cancer stem cell properties in nasopharyngeal carcinoma

description: Cancer stem cells (CSCs) represent a subpopulation of tumor cells endowed with self-renewal capacity and are considered as an underlying cause of tumor recurrence and metastasis. The metabolic signatures of CSCs and the mechanisms involved in the regulation of their stem cell-like properties still remain elusive. We utilized nasopharyngeal carcinoma (NPC) CSCs as a model to dissect their metabolic signatures and found that CSCs underwent metabolic shift and mitochondrial resetting distinguished from their differentiated counterparts. In metabolic shift, CSCs showed a greater reliance on glycolysis for energy supply compared with the parental cells. In mitochondrial resetting, the quantity and function of mitochondria of CSCs were modulated by the biogenesis of the organelles, and the round-shaped mitochondria were distributed in a peri-nuclear manner similar to those seen in the stem cells. In addition, we blocked the glycolytic pathway, increased the ROS levels, and depolarized mitochondrial membranes of CSCs, respectively, and examined the effects of these metabolic factors on CSC properties. Intriguingly, the properties of CSCs were curbed when we redirected the quintessential metabolic reprogramming, which indicates that the plasticity of energy metabolism regulated the balance between acquisition and loss of the stemness status. Taken together, we suggest that metabolic reprogramming is critical for CSCs to sustain self-renewal, deter from differentiation and enhance the antioxidant defense mechanism. Characterization of metabolic reprogramming governing CSC properties is paramount to the design of novel therapeutic strategies through metabolic intervention of CSCs.