DOI: 10.5061/dryad.j9kd51ck2
title: Data from: wired together, change together: spike timing modifies transmission in converging assemblies

description: The precise timing of neuronal spikes may lead to changes in synaptic
 connectivity and is thought to be crucial for learning and memory.
 However, the effect of spike timing on neuronal connectivity in the intact
 brain remains unknown. Using closed-loop optogenetic stimulation in CA1 of
 freely moving mice, we generated unique spike patterns between presynaptic
 pyramidal cells (PYRs) and postsynaptic parvalbumin (PV)–immunoreactive
 cells. The stimulation led to spike transmission changes that occurred
 together across all presynaptic PYRs connected to the same postsynaptic PV
 cell. The precise timing of all presynaptic and postsynaptic cell spikes
 affected transmission changes. These findings reveal an unexpected
 plasticity mechanism, in which the spike timing of an entire cell assembly
 has a more substantial impact on effective connectivity than that of
 individual cell pairs.
description: # Wired together, change together: Spike timing modifies transmission in
 converging assemblies This
 dataset encompasses extracellular recordings obtained from freely moving
 mice, integral to the research presented in our manuscript titled
 "Wired together, change together: Spike timing modifies transmission
 in converging assemblies." The data primarily consist of neuronal
 spike timing, LFP, optogenetic stimulation, and other useful information
 for working with the dataset. ## Description of the data and file
 structure The dataset is organized by session, with each folder containing
 data from a single session. Folders ending with a number (e.g., mP79_20)
 encompass data from the closed-loop experiment sessions. In contrast,
 folders ending with 'Control' contain data from control
 sessions, where no stimulation was administered during the defined
 'Before' and 'After' periods. Within each folder, data
 are further categorized into subfolders named according to the specific
 session. Each session folder houses a comprehensive set of files that
 includes: 1. **'.res' Files:** These files record spike timings
 in samples per shank. For instance, the file 'mP31_22.res.1'
 contains spike timing data from the first shank recorded in session
 'mP31_22'. 2. **'.clu' Files:** Corresponding to the
 '.res' files, these files label the spike units. The first
 element in a '.clu' file denotes the total number of recorded
 units. 3. **'.eeg' Files:** These files contain the
 extracellular data sampled at 1250 Hz, incorporating both neuronal and
 auxiliary channels such as those used for light stimulation. 4.
 **'.xml' Files:** Each '.xml' file provides
 meta-information necessary for interpreting the '.eeg' file.
 This includes details on number of channels, sampling rates, and other
 technical specifications. 5. **'.prm.xml' Files:** These contain
 metadata specific to each recorded channel. In addition to these files,
 the data includes '.xls' files, which details the times (in
 minutes) for each epoch used in the analysis, and the pairs of units which
 used in the analisys. This structured organization and detailed file
 description aim to facilitate ease of access and comprehension for
 potential data users, regardless of their familiarity with the specific
 methodologies or terminologies used in this field.