cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.26071/ogsl-6aab5849-8be4
title: Hydrocarbon Concentrations in Placentia Bay, Newfoundland, in 2022
title: Concentrations d'hydrocarbures dans la baie de Placentia, à Terre-Neuve, en 2022

description: Measurement of background concentrations of oil hydrocarbons in Placentia Bay, Newfoundland. Surface seawater for measurement of n-alkanes and PAHs (polycyclic aromatic hydrocarbons) was collected fall of 2022, in both open water and close to the shore. Establishing background oil concentrations in Placentia Bay will contribute to characterize the status quo of fossil hydrocarbons in seawater, which is a pre-requisite for the assessment of change. Damage assessment in case of a spill and the development of response plans requires the knowledge of pre-spill background values. This project is part of the Coastal Environmental Baseline Program Initiative under the Oceans Protection Plan of Fisheries and Oceans Canada.
description: Mesure des concentrations ambiantes d'hydrocarbures pétroliers dans la baie de Placentia, à Terre-Neuve. L'eau de mer de surface destinée à la mesure des n-alcanes et des HAP (hydrocarbures aromatiques polycycliques) a été collectée à l'automne 2022, à la fois en eau libre et à proximité du rivage. L'établissement des concentrations de référence de pétrole dans la baie de Placentia contribuera à caractériser le statu quo des hydrocarbures fossiles dans l'eau de mer, ce qui est une condition préalable à l'évaluation du changement. L'évaluation des dommages en cas de déversement et l'élaboration de plans d'intervention nécessitent la connaissance des valeurs de base antérieures au déversement. Ce projet fait partie du Programme sur les données environnementales côtières de référence de Pêches et Océan Canada.
DOI: 10.5683/sp2/pniusa
title: Replication Data for: ELA Leeches Proportion of Community by Each Species

description: Proportion of the leech community made up by each species in each lake before and after EE2 treatment (1999-2000)
DOI: 10.6084/m9.figshare.24233629.v7
title: <b>Efficient Object-Relational Database Design Optimization through Learning-Powered Systematic Tradeoff Analysis</b>

description: Optimizing object-relational database mapping (ORM) design is essential for software system performance. However, current ORM design tools widely used in practice offer limited support for evaluating performance implications. State-of-the-art relying on systematic tradeoff analysis provides greater assistance but becomes impractical for large-scale, real-world systems. In this paper, we introduce an innovative solution grounded in machine learning to efficiently and scalably identify optimal ORM database tradeoffs.Our approach involves training a transformer model using a dataset of formally analyzed object-relational database designs to identify Pareto-optimal design tradeoffs, significantly reducing the number of design candidates. The extensive experiments across various software database systems demonstrate the high effectiveness of the approach in identifying optimal design alternatives overlooked by leading ORM tools. Additionally, our results show a remarkable 98.21\% improvement in analysis efficiency compared to the current state-of-the-art, reducing tradeoff analysis time from over 15 days to around 18 minutes on average.<br><br>
DOI: 10.6084/m9.figshare.8981696
title: Additional file 1: of A high density SLAF-seq SNP genetic map and QTL for seed size, oil and protein content in upland cotton

description: Table S1. Variation of cottonseed traits for the RIL population in three environments. (XLSX 12 kb)
DOI: 10.6084/m9.figshare.8981714.v1
title: Additional file 4: of Transcriptome profiling of Gerbera hybrida reveals that stem bending is caused by water stress and regulation of abscisic acid

description: List of DEGs between different stem bending stages. (XLSX 2643 kb)
DOI: 10.21223/xqkkcx
title: Dataset for: Novel trait discovery for LB resistance in wild potato background (Second trial_Kenya)

description: 319 genotypes from twenty-six biparental populations from crosses of wild potato species S. megistacrolobum, S. microdontum, S. tarijense and self-compatible (SC) 2x hybrid derived from crossing 2x landraces with SC sources of S. chacoense were exposed to late blight under natural infection. Statistical Augmented row-column design without replication of 3 hill plots was properly established, five varieties with known late blight response were included as controls. After 30 days after planting (DAP), the percentage of leaf area affected by late blight infection was recorded by plot throughout the season to subsequently compute the area under the disease progress curve (AUDPC).
DOI: 10.21223/xqkkcx/t32gut
title: 04_Data_dictionary_CWR_2023_LateBlight_dv_Kenya.tab

description: :unav
DOI: 10.6084/m9.figshare.12127251
title: Puerarin inhibits hepatocellular carcinoma invasion and metastasis through miR-21-mediated PTEN/AKT signaling to suppress the epithelial-mesenchymal transition

description: Hepatocellular carcinoma (HCC) is one of the most common primary malignant tumors of the liver worldwide. Liver resection and transplantation are currently the only effective treatments; however, recurrence and metastasis rates are still high. Previous studies have shown that the epithelial-mesenchymal transition (EMT) is a key step in HCC invasion and metastasis. Inhibition of EMT has become a new therapeutic strategy for tumors. Recently, puerarin, a well-characterized component of traditional Chinese medicine, has been isolated from Pueraria radix and exerts positive effects on many diseases, particularly cancers. In this study, CCK-8, EdU immunofluorescence, colony formation, wound healing, and migration assays were used to detect the effects of puerarin on HCC cells. We further analyzed the relationship between puerarin and miR-21/PTEN/EMT markers in HCC cell lines. Our results showed that HCC cell proliferation, migration, invasion, tumor formation, and metastasis were reduced by puerarin in vitro and in vivo. Additionally, puerarin inhibited the EMT process of HCC by affecting the expression of Slug and Snail. Moreover, oncogenic miR-21 was inhibited by puerarin, coupled with an increase in the tumor suppressor gene PTEN. Increasing miR-21 expression or decreasing PTEN expression reversed the inhibition effects of puerarin in HCC. These data confirmed that puerarin affects HCC through the miR-21/PTEN/EMT regulatory axis. Overall, puerarin may represent a chemopreventive and/or chemotherapeutic agent for HCC treatment.
DOI: 10.6084/m9.figshare.22612913
title: Additional file 2 of TNEA therapy promotes the autophagic degradation of NLRP3 inflammasome in a transgenic mouse model of Alzheimer’s disease via TFEB/TFE3 activation

description: Additional file 2. Table S1. Source data and statistical analysis.
DOI: 10.6084/m9.figshare.8981720
title: Additional file 5: of Transcriptome profiling of Gerbera hybrida reveals that stem bending is caused by water stress and regulation of abscisic acid

description: Significantly enriched GO terms between different stem bending stages. (XLSX 20 kb)
DOI: 10.6084/m9.figshare.8981702
title: Additional file 3: of Transcriptome profiling of Gerbera hybrida reveals that stem bending is caused by water stress and regulation of abscisic acid

description: Correlation coefficients of two sequencing replicates. (XLS 20 kb)
DOI: 10.6084/m9.figshare.8981732.v1
title: Additional file 4: of A high density SLAF-seq SNP genetic map and QTL for seed size, oil and protein content in upland cotton

description: Table S4. Characteristics of SLAFs and SNPs. (XLSX 9 kb)
DOI: 10.6084/m9.figshare.22612913.v1
title: Additional file 2 of TNEA therapy promotes the autophagic degradation of NLRP3 inflammasome in a transgenic mouse model of Alzheimer’s disease via TFEB/TFE3 activation

description: Additional file 2. Table S1. Source data and statistical analysis.
DOI: 10.6084/m9.figshare.12127251.v1
title: Puerarin inhibits hepatocellular carcinoma invasion and metastasis through miR-21-mediated PTEN/AKT signaling to suppress the epithelial-mesenchymal transition

description: Hepatocellular carcinoma (HCC) is one of the most common primary malignant tumors of the liver worldwide. Liver resection and transplantation are currently the only effective treatments; however, recurrence and metastasis rates are still high. Previous studies have shown that the epithelial-mesenchymal transition (EMT) is a key step in HCC invasion and metastasis. Inhibition of EMT has become a new therapeutic strategy for tumors. Recently, puerarin, a well-characterized component of traditional Chinese medicine, has been isolated from Pueraria radix and exerts positive effects on many diseases, particularly cancers. In this study, CCK-8, EdU immunofluorescence, colony formation, wound healing, and migration assays were used to detect the effects of puerarin on HCC cells. We further analyzed the relationship between puerarin and miR-21/PTEN/EMT markers in HCC cell lines. Our results showed that HCC cell proliferation, migration, invasion, tumor formation, and metastasis were reduced by puerarin in vitro and in vivo. Additionally, puerarin inhibited the EMT process of HCC by affecting the expression of Slug and Snail. Moreover, oncogenic miR-21 was inhibited by puerarin, coupled with an increase in the tumor suppressor gene PTEN. Increasing miR-21 expression or decreasing PTEN expression reversed the inhibition effects of puerarin in HCC. These data confirmed that puerarin affects HCC through the miR-21/PTEN/EMT regulatory axis. Overall, puerarin may represent a chemopreventive and/or chemotherapeutic agent for HCC treatment.
DOI: 10.6084/m9.figshare.8981468
title: Additional file 1: of Preoperative systemic inflammation score (SIS) is superior to neutrophil to lymphocyte ratio (NLR) as a predicting indicator in patients with esophageal squamous cell carcinoma

description: File SIS DATA information. The file included the data of the pretreatment NLR, LMR, Albumin and survival time of 357 ESCC patients. The gender, tumor location, tumor length, age, tumor cell differentiation, vascular invasion, T stage, N stage, clinical stage, NLR, LMR and albumin were divided into different subgroups according to the details list in the TablesÂ 1 and 2. Survival time was defined as the interval between the date of surgery to the death or last follow-up. The survival group was divided into 2 subgroups (0 for survival and 1 for death). (XLSX 59 kb)
DOI: 10.6084/m9.figshare.5835741.v1
title: Octreotide-modified liposomes containing daunorubicin and dihydroartemisinin for treatment of invasive breast cancer

description: Tumor invasion is considered a major promoter in the initiation of tumor metastasis, which is supposed to cause most cancer-related deaths. In the present study, octreotide (OCT)-modified daunorubicin plus dihydroartemisinin liposomes were developed and characterized. Evaluations were undertaken on breast cancer MDA-MB-435S cells and MDA-MB-435S xenografts nude mice. The liposomes were ∼100 nm in size with a narrow polydispersity index. <i>In vitro</i> results showed that the OCT-modified daunorubicin plus dihydroartemisinin liposomes could enhance cytotoxicity and cellular uptake by OCT-SSTRs (somatostatin receptors)-mediated active targeting, block on tumor cell wound healing and migration by incorporating dihydroartemisinin. The action mechanism might be related to regulations on E-cadherin, α5β1-integrin, TGF-β1, VEGF and MMP2/9 in breast cancer cells. <i>In vivo</i>, the liposomes displayed a prolonged circulating time, more accumulation in tumor location, and a robust overall antitumor efficacy with no obvious toxicity at the test dose in MDA-MB-435S xenograft mice. In conclusion, the OCT-modified daunorubicin plus dihydroartemisinin liposomes could prevent breast cancer invasion, hence providing a possible strategy for treatment of metastatic breast cancer.
DOI: 10.6084/m9.figshare.8981702.v1
title: Additional file 3: of Transcriptome profiling of Gerbera hybrida reveals that stem bending is caused by water stress and regulation of abscisic acid

description: Correlation coefficients of two sequencing replicates. (XLS 20 kb)
DOI: 10.6084/m9.figshare.12127293.v1
title: Anti-inflammation and anti-apoptosis effects of growth arrest-specific protein 6 in acute liver injury induced by LPS/D-GalN in mice

description: Abstract Purpose To investigate the effect of growth arrest-specific protein 6 (Gas6) on acute liver injury in mice and related mechanisms. Methods Thirty C57BL/6 (6-8 weeks old) mice were randomly divided into control, LPS/D-GalN, and LPS/D-GalN+Gas6 groups (10 mice in each group). The LPS/D-GalN group was intraperitoneally administered with LPS (0.25 mg/Kg) and D-GalN (400 mg/Kg) for 5h. The LPS/D-GalN+Gas6 group was intraperitoneally administered with rmGas6 one hour before intraperitoneal application of LPS/D-GalN. All subjects were sacrificed at 5 h for blood and tissue analysis. The expression of protein and mRNA was assessed by western blotting and RT-PCR, respectively. Results Compared with the control group, AST, ALT, IL-1β, TNF-α, IL-6 IL-10, MPO activity were increased in the LPS/D-GalN group. However, they were significantly inhibited by Gas6. Gas6 markedly suppressed the expression of apoptosis-related protein induced by LPS/D-GalN. Moreover, Gas6 attenuated the activation of the NF-κB signaling pathway in acute liver injury induced by LPS/D-GalN. Conclusions Gas6 alleviates acute liver injury in mice through regulating NF-κB signaling pathways. Gas6 can be a potential therapeutic agent in treating LPS/D-GalN-induced acute liver injury in the future.
DOI: 10.6084/m9.figshare.8981696.v1
title: Additional file 1: of A high density SLAF-seq SNP genetic map and QTL for seed size, oil and protein content in upland cotton

description: Table S1. Variation of cottonseed traits for the RIL population in three environments. (XLSX 12 kb)
DOI: 10.6084/m9.figshare.8981711
title: Additional file 2: of A high density SLAF-seq SNP genetic map and QTL for seed size, oil and protein content in upland cotton

description: Table S2. Correlation analysis among fiber quality traits across three environments. (XLSX 10 kb)
DOI: 10.6084/m9.figshare.8981720.v1
title: Additional file 5: of Transcriptome profiling of Gerbera hybrida reveals that stem bending is caused by water stress and regulation of abscisic acid

description: Significantly enriched GO terms between different stem bending stages. (XLSX 20 kb)
DOI: 10.6084/m9.figshare.8981726
title: Additional file 6: of Transcriptome profiling of Gerbera hybrida reveals that stem bending is caused by water stress and regulation of abscisic acid

description: Up-regulated TFs during stem-bending process. |log2FC| ≥ 1 at least at one stage and FDR &lt; 0.05. (XLSX 32 kb)
DOI: 10.6084/m9.figshare.8981732
title: Additional file 4: of A high density SLAF-seq SNP genetic map and QTL for seed size, oil and protein content in upland cotton

description: Table S4. Characteristics of SLAFs and SNPs. (XLSX 9 kb)
DOI: 10.5281/zenodo.10630970
title: Structure and thermodynamics of defects in Na-feldspar from a neural network potential - Accompanying Data

description: This dataset accompanies the manuscript: "Structure and thermodynamics of defects in Na-feldspar from a neural network potential". It contains the neural network potential committee with corrections NNPw/corr, the training and testing data, lammps-data files of 2x2x2 systems containing the defects and a template input file for molecular dynamics.
DOI: 10.6084/m9.figshare.22612946
title: Additional file 2 of Integrated metabolomic and transcriptomic analyses of regulatory mechanisms associated with uniconazole-induced dwarfism in banana

description: Additional file 2.
DOI: 10.6084/m9.figshare.8981723
title: Additional file 3: of A high density SLAF-seq SNP genetic map and QTL for seed size, oil and protein content in upland cotton

description: Table S3. Analysis of variance (ANOVA) for cottonseed traits across three environments for the Yumian 1â Ă â M11 RIL population. (XLSX 10 kb)
DOI: 10.6084/m9.figshare.8981714
title: Additional file 4: of Transcriptome profiling of Gerbera hybrida reveals that stem bending is caused by water stress and regulation of abscisic acid

description: List of DEGs between different stem bending stages. (XLSX 2643 kb)
DOI: 10.6084/m9.figshare.8981723.v1
title: Additional file 3: of A high density SLAF-seq SNP genetic map and QTL for seed size, oil and protein content in upland cotton

description: Table S3. Analysis of variance (ANOVA) for cottonseed traits across three environments for the Yumian 1â Ă â M11 RIL population. (XLSX 10 kb)
DOI: 10.6084/m9.figshare.8981726.v1
title: Additional file 6: of Transcriptome profiling of Gerbera hybrida reveals that stem bending is caused by water stress and regulation of abscisic acid

description: Up-regulated TFs during stem-bending process. |log2FC| ≥ 1 at least at one stage and FDR &lt; 0.05. (XLSX 32 kb)
DOI: 10.6084/m9.figshare.22607378.v1
title: Additional file 7 of FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia

description: Additional file 7. Table S2. Mass spectrometry data
DOI: 10.6084/m9.figshare.21564309
title: Additional file 8 of FMO3 deficiency of duck leads to decreased lipid deposition and increased antibacterial activity

description: Additional file 8: Table S1. FMO3 mRNA expression in the CL and TH groups.
DOI: 10.6084/m9.figshare.22607360.v1
title: Additional file 1 of FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia

description: Additional file 1. Table S1. Reagents, primers and plasmids used and patients’ information
DOI: 10.6084/m9.figshare.6884657.v1
title: High-resolution gridded soil moisture and soil temperature datasets for the Indian monsoon region

description: The soil moisture and soil temperature data at 4 km spatial resolution is developed over Indian Monsoon Region using Land Data Assimilation System that incorporates high quality surface meteorological parameters, land use and vegetation characteristics from observations and analysis product.
DOI: 10.6084/m9.figshare.19396089
title: Additional file 1 of The identification of alternative oxidase in intermediate host snails of Schistosoma and its potential role in protecting Oncomelania hupensis against niclosamide-induced stress

description: Additional file 1: Table S1. The gene-specific primers used in the 5'- and 3-end RACE-PCR and specific primers used to amplify OhAOX, BgAOX, BaAOX, and BsAOX.
DOI: 10.6084/m9.figshare.22613114
title: Additional file 3 of Using strain-resolved analysis to identify contamination in metagenomics data

description: Additional file 3: Table S1. The original and the re-extracted DNA concentrations of four cross-contaminated samples from case study I. *: The re-extracted stool sample (#63D6) is not the same as the original one (#63D9) as the original stool sample is unavailable. This alternative stool sample was collected 3 days earlier than the original sample. The original and the re-extracted DNA concentrations of four cross-contaminated samples from case study I.
DOI: 10.6084/m9.figshare.22613114.v1
title: Additional file 3 of Using strain-resolved analysis to identify contamination in metagenomics data

description: Additional file 3: Table S1. The original and the re-extracted DNA concentrations of four cross-contaminated samples from case study I. *: The re-extracted stool sample (#63D6) is not the same as the original one (#63D9) as the original stool sample is unavailable. This alternative stool sample was collected 3 days earlier than the original sample. The original and the re-extracted DNA concentrations of four cross-contaminated samples from case study I.
DOI: 10.24414/srvz-2k77
title: Les tremblements de terre en Europe au Moyen Âge et à la Renaissance. Étude critique des sources et catalogue des tremblements de terre en Europe de 284 à 1550.

description: This book is a new critical catalogue of earthquakes in Europe from 284 to 1550, as known from the original written sources. The first part of the book is a critical study of the written sources that provide us with information on earthquakes. 2,489 sources have been listed. In total, the number of original texts is 4,641, of which 1,273 (27%) come from lost sources. The second part is the actual catalogue of 1,507 earthquakes, classified in chronological order. In appendix to this catalogue, a table of 4,534 macroseismic datapoints (MDPs) is presented, i.e. all the localities where each of the 1,507 seismic events have been felt. The third and last part of the book is a catalogue of 1,585 false earthquakes.
DOI: 10.60520/ieda/113126
title: Six mafic and one intermediate whole rock lava samples from south-central Vietnam: 40Ar/39Ar geochronology.

description: 40Ar/39Ar isotope data measured from the groundmass of six mafic and one intermediate whole rock lava sample from south-central Vietnam to determine their eruption ages.
DOI: 10.6084/m9.figshare.22613152
title: Additional file 5 of MNX1-AS1, a c-Myc induced lncRNA, promotes the Warburg effect by regulating PKM2 nuclear translocation

description: Additional file 5.
DOI: 10.6084/m9.figshare.22613140
title: Additional file 1 of MNX1-AS1, a c-Myc induced lncRNA, promotes the Warburg effect by regulating PKM2 nuclear translocation

description: Additional file 1.
DOI: 10.6084/m9.figshare.22613146.v1
title: Additional file 3 of MNX1-AS1, a c-Myc induced lncRNA, promotes the Warburg effect by regulating PKM2 nuclear translocation

description: Additional file 3.
DOI: 10.6084/m9.figshare.22613152.v1
title: Additional file 5 of MNX1-AS1, a c-Myc induced lncRNA, promotes the Warburg effect by regulating PKM2 nuclear translocation

description: Additional file 5.
DOI: 10.6084/m9.figshare.22613140.v1
title: Additional file 1 of MNX1-AS1, a c-Myc induced lncRNA, promotes the Warburg effect by regulating PKM2 nuclear translocation

description: Additional file 1.
DOI: 10.6084/m9.figshare.22613146
title: Additional file 3 of MNX1-AS1, a c-Myc induced lncRNA, promotes the Warburg effect by regulating PKM2 nuclear translocation

description: Additional file 3.
DOI: 10.6084/m9.figshare.22613143.v1
title: Additional file 2 of MNX1-AS1, a c-Myc induced lncRNA, promotes the Warburg effect by regulating PKM2 nuclear translocation

description: Additional file 2.