DOI: 10.7270/q2zc85hx
title: BindingDB Entry 50002826: ROCK inhibitors 3: Design, synthesis and structure-activity relationships of 7-azaindole-based Rho kinase (ROCK) inhibitors.

description: Small molecule binding data for protein Aurora kinase A/Targeting protein for Xklp2, Aurora kinase B, Axin-1/Glycogen synthase kinase-3 beta, BR serine/threonine-protein kinase 1, BR serine/threonine-protein kinase 2, CAMK2A, CAMK2B, CaM kinase I delta, CaM kinase IV, Casein kinase I isoform alpha, Ceramide kinase, Choline kinase alpha, Citron Rho-interacting kinase, Cyclin-Dependent Kinase 1 (CDK1), Cyclin-Dependent Kinase 2 (CDK2), Cyclin-Dependent Kinase 5 (CDK5), Cytochrome P450 3A, DNA-dependent protein kinase, Death-associated protein kinase 1, Dual specificity mitogen-activated protein kinase kinase 1/Mitogen-activated protein kinase 1/RAF proto-oncogene serine/threonine-protein kinase, Dual specificity mitogen-activated protein kinase kinase 6, Dual specificity mitogen-activated protein kinase kinase 7 (MAP2K7), Dual specificity protein kinase CLK3, Dual-specificity tyrosine-phosphorylation regulated kinase 1A, Dual-specificity tyrosine-phosphorylation regulated kinase 2, Ephrin receptor, Ephrin type-B receptor 2, Ephrin type-B receptor 4, Epidermal growth factor receptor, Fibroblast growth factor receptor 1, Fibroblast growth factor receptor 2, Fibroblast growth factor receptor 3, Fibroblast growth factor receptor 4, Focal adhesion kinase 1, Focal adhesion kinase 1/vascular endothelial growth factor receptor 3, Hepatocyte growth factor receptor, Inhibitor of NF-kappa-B kinase alpha/beta, Inhibitor of nuclear factor kappa-B kinase subunit beta, Insulin receptor, Insulin-like growth factor I receptor, Interleukin-1 receptor-associated kinase 1, Interleukin-1 receptor-associated kinase 4, MAP kinase ERK1, MAP kinase-activated protein kinase 2, MAP kinase-activated protein kinase 5, MAP/microtubule affinity-regulating kinase 3, Macrophage colony-stimulating factor 1 receptor, Macrophage-stimulating protein receptor, Mast/stem cell growth factor receptor Kit, Mitogen-activated protein kinase 1, Mitogen-activated protein kinase 10, Mitogen-activated protein kinase 11, Mitogen-activated protein kinase 12, Mitogen-activated protein kinase 14, Mitogen-activated protein kinase 8/9, Mitogen-activated protein kinase kinase kinase 14, Mitogen-activated protein kinase kinase kinase 7, Mitogen-activated protein kinase kinase kinase 8, Mitogen-activated protein kinase kinase kinase kinase 4, PAK 1/CDC42, PAS domain-containing serine/threonine-protein kinase, PIK3CG/PIK3R1, PKC alpha and beta-2, PTK2B protein tyrosine kinase 2 beta (PTK2B), Phosphorylase kinase, Platelet-derived growth factor receptor, Protein kinase C iota type/zeta type, Protein kinase C theta type, Protein kinase C, PKC; classical/novel, Protein kinase N2, Proto-oncogene tyrosine-protein kinase ROS, Proto-oncogene tyrosine-protein kinase Src, Proto-oncogene tyrosine-protein kinase receptor Ret, RAC-alpha serine/threonine-protein kinase AKT1, RAF proto-oncogene serine/threonine-protein kinase, Rho-associated protein kinase 1, Rho-associated protein kinase 2, Ribosomal protein S6 kinase, Ribosomal protein S6 kinase alpha 1, Ribosomal protein S6 kinase alpha 2, Ribosomal protein S6 kinase alpha 4, Ribosomal protein S6 kinase alpha-1/alpha-3, SRC, Serine/threonine-protein kinase 4 (STK4), Serine/threonine-protein kinase AKT, Serine/threonine-protein kinase AKT2, Serine/threonine-protein kinase ATR, Serine/threonine-protein kinase Aurora-C, Serine/threonine-protein kinase Chk1/2, Serine/threonine-protein kinase D2, Serine/threonine-protein kinase DCLK1, Serine/threonine-protein kinase DCLK2, Serine/threonine-protein kinase MARK1, Serine/threonine-protein kinase MST2, Serine/threonine-protein kinase NEK2, Serine/threonine-protein kinase Nek1, Serine/threonine-protein kinase PAK 2, Serine/threonine-protein kinase PLK1, Serine/threonine-protein kinase Sgk1, Serine/threonine-protein kinase Sgk2, Serine/threonine-protein kinase Sgk3, Serine/threonine-protein kinase TBK1, Serine/threonine-protein kinase pim-1, Serine/threonine-protein kinase pim-2, Sphingosine kinase 1, TEC family kinase, Testis-specific serine/threonine-protein kinase 2, Tyrosine-protein kinase ABL1, Tyrosine-protein kinase BTK, Tyrosine-protein kinase Blk, Tyrosine-protein kinase CSK, Tyrosine-protein kinase FER, Tyrosine-protein kinase FES, Tyrosine-protein kinase Fyn, Tyrosine-protein kinase HCK, Tyrosine-protein kinase ITK/TSK, Tyrosine-protein kinase JAK2, Tyrosine-protein kinase JAK3, Tyrosine-protein kinase Lyn, Tyrosine-protein kinase Mer, Tyrosine-protein kinase SYK, Tyrosine-protein kinase Yes, Tyrosine-protein kinase ZAP-70, Tyrosine-protein kinase receptor FLT3, Tyrosine-protein kinase receptor TYRO3, Vascular endothelial growth factor receptor 1, Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2), Voltage-gated potassium channel subunit Kv7.1/Misshapen-like kinase 1, p21-Activated kinase 3 (PAK3), and p38 delta/gamma, Uniprot A0A024QYW7, A0A024R244, A0A024R4U8, A0A024R5P0, A0A024R720, A0A024R759, A0A024R7M7, A0A024R7T2, A0A024R807, A0A024R8E2, A0A024RB77, A0A024RC92, A0A024RD04, A0A024RD15, A0A024RD25, A0A090N7W4, A0A0S2Z3Y8, A0A2P9DU05, A0A384MDW3, A0A384MR07, A0ZT99, A1MA61, A4D2J9, A4QPA9, A8K3Y2, B0LPE5, B2R6Q4, L7RRS6, L7RSL3, L7RTI5, L7RXH5, O00141, O14578, O14733, O14757, O14920, O14965, O15075, O15111, O15264, O43318, O60674, O75116, O75582, O75676, O75914, O94806, O95819, O96017, P00519, P00533, P04049, P05129, P05771, P06213, P06239, P06241, P06493, P07332, P07333, P07947, P07948, P07949, P08069, P08581, P08631, P08684, P08922, P10721, P11309, P11362, P12931, P14635, P15735, P16234, P16591, P17948, P20248, P21802, P22455, P22607, P23443, P24941, P27361, P27448, P28482, P29323, P31749, P31751, P35790, P35916, P35968, P36888, P41240, P41279, P41743, P43403, P43405, P45983, P48729, P48736, P49137, P49761, P49841, P51451, P51617, P51812, P51813, P51955, P52333, P52564, P53350, P53355, P53778, P53779, P54760, P54764, P78527, Q00535, Q02156, Q02750, Q02763, Q04759, Q04912, Q05397, Q06187, Q06418, Q08881, Q12866, Q13043, Q13153, Q13177, Q13188, Q13464, Q13535, Q13554, Q13627, Q14289, Q15078, Q15139, Q15349, Q15418, Q15759, Q16513, Q16539, Q16566, Q1HBJ4, Q53ZR5, Q541P7, Q69FE3, Q6FI27, Q6GRK0, Q7LDD5, Q8IU85, Q8IW41, Q8IWQ3, Q8N4C8, Q8N568, Q8TCT0, Q8TDC3, Q92630, Q96BR1, Q96GD4, Q96PF2, Q96PY6, Q96RG2, Q99558, Q9BZL6, Q9HBY8, Q9NWZ3, Q9NYA1, Q9P0L2, Q9P1W9, Q9UBS0, Q9UHD2, Q9UK32, Q9UQB9, Q9UQM7, Q9Y243, and W0S0X4