cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.21856177.v1
title: Adverse events related to oral hormonal contraceptive use in undergraduate pharmacy students: a cross-sectional study

description: Abstract We aimed to measure the prevalence of adverse events related to oral hormonal contraceptive (OHC) use and their associated factors in undergraduate pharmacy students. A cross-sectional study was conducted by using an online questionnaire for female students of the Faculty of Pharmaceutical Sciences of the University of São Paulo from July to August 2020. A descriptive analysis of the data was carried out, which was followed by determining the prevalence ratios to identify possible factors associated with adverse events resulting from OHC. A total of 269 valid responses were obtained, among which 50.2% (n = 135) of the students reported using OHC as a contraceptive method and 21.2% (n = 57) affirmed that they had at least one adverse event related to OHC use, which corresponds to 42.2% of those who had used OHC. The most common adverse event was headache (70.2%), and a period of less than one month was the most cited (49.1%). Only migraine comorbidity was associated with the occurrence of adverse events related to OHC. These findings reinforce the high incidence of adverse events among OHC users and the low rate of discontinuation due to these events. There is a need to provide more information on contraceptive methods to users, including its risks and contraindications.
DOI: 10.6084/m9.figshare.21856180.v1
title: The Use of the Borg Rating of Perceived Exertion Scale in Cardiopulmonary Resuscitation

description: Abstract Background A cardiopulmonary arrest is a critical event whose survival rate is related to the quality of resuscitation maneuvers combined with the use of technology. It is important to understand the perception of fatigue during this procedure, aiming to improve the effectiveness of compressions to increase the chances of survival. Objectives To apply the Borg rating of perceived exertion scale (Borg scale) to analyze the exertion perceived by nurses during cardiopulmonary resuscitation maneuvers using a feedback device. Methods Experimental study with a randomized distribution of nurses in a teaching hospital. Perceived exertion during simulated cardiopulmonary resuscitation with/without a feedback device was assessed using the Borg scale. The statistical significance level of 5% was adopted. Results 69 nurses working in critical and non-critical adult care units were included. Perceived exertion and heart rate were lower in the intervention group (p&lt;0.001), influenced by the feedback device, with no significant difference between critical and non-critical units. Conclusions The Borg scale proved to be adequate for the proposed objectives. The feedback device contributed to lower exertion and heart rate reduction during resuscitation maneuvers. The low cost and ease of application favor its use during training and real-time resuscitation attempts to assess performance using a feedback device to reduce exertion and perception of fatigue. It allows reflection on the intervening factors and resources that can influence the quality of resuscitation attempts and the chances of survival.
DOI: 10.6084/m9.figshare.21856180
title: The Use of the Borg Rating of Perceived Exertion Scale in Cardiopulmonary Resuscitation

description: Abstract Background A cardiopulmonary arrest is a critical event whose survival rate is related to the quality of resuscitation maneuvers combined with the use of technology. It is important to understand the perception of fatigue during this procedure, aiming to improve the effectiveness of compressions to increase the chances of survival. Objectives To apply the Borg rating of perceived exertion scale (Borg scale) to analyze the exertion perceived by nurses during cardiopulmonary resuscitation maneuvers using a feedback device. Methods Experimental study with a randomized distribution of nurses in a teaching hospital. Perceived exertion during simulated cardiopulmonary resuscitation with/without a feedback device was assessed using the Borg scale. The statistical significance level of 5% was adopted. Results 69 nurses working in critical and non-critical adult care units were included. Perceived exertion and heart rate were lower in the intervention group (p&lt;0.001), influenced by the feedback device, with no significant difference between critical and non-critical units. Conclusions The Borg scale proved to be adequate for the proposed objectives. The feedback device contributed to lower exertion and heart rate reduction during resuscitation maneuvers. The low cost and ease of application favor its use during training and real-time resuscitation attempts to assess performance using a feedback device to reduce exertion and perception of fatigue. It allows reflection on the intervening factors and resources that can influence the quality of resuscitation attempts and the chances of survival.
DOI: 10.6084/m9.figshare.21856183
title: A systematic review of preclinical animal studies on fenofibrate’s potential role in type 1 diabetic micro-vascular complications

description: Abstract Fenofibrate is a peroxisome-proliferator-activator α agonist and it is a widely used drug for hyperlipidemia since its approval in 2004. So, in this review we are focusing on the effect of fenofibric acid’s mechanism to alleviate type 1 diabetic micro vascular complications like diabetic retinopathy, diabetic cardiomyopathy in animal models, since the drug is safe, efficacious and more economical when compared with the currently available treatment strategies for juvenile diabetic complications and also a profound observation is needed due to the rarity of research in these therapeutic areas. Important preclinical animal studies published from January 2001 to June 2020 were recognised from databases like PubMed and Cochrane central register of controlled trials. Reviewers screened the articles based on the selection criteria and risk of bias was determined using Systematic Review Centre for Laboratory animal Experimentation risk of bias tool for animal studies. Our literature search yielded a total of 5 studies and after pooling up the data from the 5 preclinical studies, we found that Fenofibrate have the efficacy to prevent type 1 diabetic complications, chiefly diabetic retinopathy and those mechanisms are dependent on peroxisome-proliferator-activator and fibroblast growth factor-21 pathways. Fenofibrate is a well safe and moreover, cost effective medication in preventing type 1 diabetic micro vascular complications especially diabetic retinopathy and also in maintaining the glucose homeostasis in apart from its anti-dyslipidemic effect.
DOI: 10.6084/m9.figshare.21856183.v1
title: A systematic review of preclinical animal studies on fenofibrate’s potential role in type 1 diabetic micro-vascular complications

description: Abstract Fenofibrate is a peroxisome-proliferator-activator α agonist and it is a widely used drug for hyperlipidemia since its approval in 2004. So, in this review we are focusing on the effect of fenofibric acid’s mechanism to alleviate type 1 diabetic micro vascular complications like diabetic retinopathy, diabetic cardiomyopathy in animal models, since the drug is safe, efficacious and more economical when compared with the currently available treatment strategies for juvenile diabetic complications and also a profound observation is needed due to the rarity of research in these therapeutic areas. Important preclinical animal studies published from January 2001 to June 2020 were recognised from databases like PubMed and Cochrane central register of controlled trials. Reviewers screened the articles based on the selection criteria and risk of bias was determined using Systematic Review Centre for Laboratory animal Experimentation risk of bias tool for animal studies. Our literature search yielded a total of 5 studies and after pooling up the data from the 5 preclinical studies, we found that Fenofibrate have the efficacy to prevent type 1 diabetic complications, chiefly diabetic retinopathy and those mechanisms are dependent on peroxisome-proliferator-activator and fibroblast growth factor-21 pathways. Fenofibrate is a well safe and moreover, cost effective medication in preventing type 1 diabetic micro vascular complications especially diabetic retinopathy and also in maintaining the glucose homeostasis in apart from its anti-dyslipidemic effect.
DOI: 10.6084/m9.figshare.21856186
title: The constitution of the subfield of chemistry teacher training and subversion strategies for its recognition in the scientific field of Chemistry

description: ABSTRACT In order to understand the research on the chemistry teacher training from the sociology of science, the scientific paper aims to explore the theory of fields, formulated by Pierre Bourdieu with a direction in the area of Chemistry Teaching and in the structuring of the subfield of the chemistry teacher training (FPQ) based on the concepts of field, habitus, capital and subversion strategy. The field was discussed as a social space with a focus on the scientific field of chemistry (CCQ), the habitus of the agents, positions, disputes, interests and subversion strategies established by the FPQ subfield to reveal its space in chemistry. It is argued about these different configurations by the perspective at the FPQ subfield dominated in the field of chemistry, when analyzing the scientific production of the chemistry teaching area and the Acácia and Sucupira platforms for data collection. The praxiological methodology of Bourdieu was used in this process and his relational analysis to discuss about the strategies developed by the agents of the FPQ subfield in the CCQ to configure own capital and establish a movement of habitus recognition that is not the own habitus of the chemists. Among such strategies, the holding of scientific events stands out, production in journals in the area of Chemistry Teaching, training of masters and doctors in postgraduate programs in which agents seek to establish a scientific capital and space for the recognition of the subfield as belonging to the field of chemistry.
DOI: 10.6084/m9.figshare.21856186.v1
title: The constitution of the subfield of chemistry teacher training and subversion strategies for its recognition in the scientific field of Chemistry

description: ABSTRACT In order to understand the research on the chemistry teacher training from the sociology of science, the scientific paper aims to explore the theory of fields, formulated by Pierre Bourdieu with a direction in the area of Chemistry Teaching and in the structuring of the subfield of the chemistry teacher training (FPQ) based on the concepts of field, habitus, capital and subversion strategy. The field was discussed as a social space with a focus on the scientific field of chemistry (CCQ), the habitus of the agents, positions, disputes, interests and subversion strategies established by the FPQ subfield to reveal its space in chemistry. It is argued about these different configurations by the perspective at the FPQ subfield dominated in the field of chemistry, when analyzing the scientific production of the chemistry teaching area and the Acácia and Sucupira platforms for data collection. The praxiological methodology of Bourdieu was used in this process and his relational analysis to discuss about the strategies developed by the agents of the FPQ subfield in the CCQ to configure own capital and establish a movement of habitus recognition that is not the own habitus of the chemists. Among such strategies, the holding of scientific events stands out, production in journals in the area of Chemistry Teaching, training of masters and doctors in postgraduate programs in which agents seek to establish a scientific capital and space for the recognition of the subfield as belonging to the field of chemistry.
DOI: 10.6084/m9.figshare.21856191
title: Prolongation of the QTc Interval at Admission is Associated with Increased Mortality in Patients with SARS-COV-2 during Hospitalization

description: Abstract Background Cardiovascular involvement associated with SARS-COV-2 infection is related to unfavorable outcomes during hospitalization. Therefore, the measurement at the admission of the QTc interval on the 12-lead electrocardiogram may be a prognostic marker. Objective To identify the relationship between QTc prolongation at admission during hospitalization and mortality from SARS-COV-2. Method Observational study based on a retrospective cohort of patients with confirmed SARS-COV-2 infection from San Ignacio University Hospital, Bogotá (Colombia), between March 19, 2020, and July 31, 2021. Mortality was compared in patients with prolonged and normal QTc at admission after controlling by clinical variables and comorbidities using bivariate and multivariate logistic regression models. A p-value &lt;0.05 was considered statistically significant. Results 1296 patients were analyzed, and 127 (9.8%) had prolonged QTc. Mortality was higher in patients with prolonged QTc (39.4% vs 25.3%, p=0.001), as was hospital stay (median 11vs.8 days; p=0.002). In the multivariate analysis, mortality was associated with prolonged QTc (OR 1.61, 95% CI: 1.02; 2.54, p=0.038), age (OR 1.03, 95% CI 1.02; 1.05, p&lt;0.001), male sex (OR 2.15, 95% CI 1.60; 2.90, p &lt;0.001), kidney disease (OR 1.32, 95% CI 1.05; 1.66, p =0.018) and Charlson comorbidity index &gt; 3 (OR 1.49, 95% CI 1.03; 2.17, p=0.035). Conclusions Hospital mortality due to SARS-COV-2 is associated with prolonging the QTc interval at the time of admission, even after adjusting for age, sex, comorbidities, and basal severity of infection. Additional research is needed to establish whether these findings are related to cardiac involvement by the virus, hypoxia, and systemic inflammation.
DOI: 10.6084/m9.figshare.21856191.v1
title: Prolongation of the QTc Interval at Admission is Associated with Increased Mortality in Patients with SARS-COV-2 during Hospitalization

description: Abstract Background Cardiovascular involvement associated with SARS-COV-2 infection is related to unfavorable outcomes during hospitalization. Therefore, the measurement at the admission of the QTc interval on the 12-lead electrocardiogram may be a prognostic marker. Objective To identify the relationship between QTc prolongation at admission during hospitalization and mortality from SARS-COV-2. Method Observational study based on a retrospective cohort of patients with confirmed SARS-COV-2 infection from San Ignacio University Hospital, Bogotá (Colombia), between March 19, 2020, and July 31, 2021. Mortality was compared in patients with prolonged and normal QTc at admission after controlling by clinical variables and comorbidities using bivariate and multivariate logistic regression models. A p-value &lt;0.05 was considered statistically significant. Results 1296 patients were analyzed, and 127 (9.8%) had prolonged QTc. Mortality was higher in patients with prolonged QTc (39.4% vs 25.3%, p=0.001), as was hospital stay (median 11vs.8 days; p=0.002). In the multivariate analysis, mortality was associated with prolonged QTc (OR 1.61, 95% CI: 1.02; 2.54, p=0.038), age (OR 1.03, 95% CI 1.02; 1.05, p&lt;0.001), male sex (OR 2.15, 95% CI 1.60; 2.90, p &lt;0.001), kidney disease (OR 1.32, 95% CI 1.05; 1.66, p =0.018) and Charlson comorbidity index &gt; 3 (OR 1.49, 95% CI 1.03; 2.17, p=0.035). Conclusions Hospital mortality due to SARS-COV-2 is associated with prolonging the QTc interval at the time of admission, even after adjusting for age, sex, comorbidities, and basal severity of infection. Additional research is needed to establish whether these findings are related to cardiac involvement by the virus, hypoxia, and systemic inflammation.
DOI: 10.6084/m9.figshare.21856197
title: Nutrient content and accumulation in mini lettuce as a function of fertigation management strategies

description: ABSTRACT Determining the amount of nutrients accumulated by crops is an important tool for defining the order in which nutrients are taken up and required. However, the order and amount of accumulated nutrients vary depending on the genetic characteristics of the cultivars, climatic conditions, fertilization, soil and management systems. The aim of this study was to evaluate the influence of irrigation management strategies and doses of nitrogen (N) fertigation on the content and accumulation of macro and micronutrients and the N use efficiency in mini romaine lettuce “Astorga” cultivated in a protected environment, in two consecutive crop cycles. The treatments consisted of three irrigation strategies: continuous irrigation (Cont), intermittent irrigation, with three fractions a day, at 1-hour intervals (Int1); intermittent irrigation, with three fractions a day, at 4-hour intervals (Int2) and two nitrogen doses (100 and 130 kg/ha N), in daily fertigation. Intermittent irrigation management strategies (Int1 and Int2) increased the contents and accumulation of dry matter and N, P, K, Ca, Mg, S, B, Fe, Mn and Zn. The dose of 130 kg/ha N only increased the content and accumulation of P and Mn in the first and second cycles, respectively. In general, lettuce accumulated macronutrients in the following decreasing order: K&gt;N&gt;Ca&gt;P&gt;Mg&gt;S, whereas micronutrients followed the order Fe&gt;Mn&gt;Zn&gt;B&gt;Cu. The treatments Int1, Int2 and 100 kg/ha N optimized the N use efficiency.
DOI: 10.6084/m9.figshare.21856197.v1
title: Nutrient content and accumulation in mini lettuce as a function of fertigation management strategies

description: ABSTRACT Determining the amount of nutrients accumulated by crops is an important tool for defining the order in which nutrients are taken up and required. However, the order and amount of accumulated nutrients vary depending on the genetic characteristics of the cultivars, climatic conditions, fertilization, soil and management systems. The aim of this study was to evaluate the influence of irrigation management strategies and doses of nitrogen (N) fertigation on the content and accumulation of macro and micronutrients and the N use efficiency in mini romaine lettuce “Astorga” cultivated in a protected environment, in two consecutive crop cycles. The treatments consisted of three irrigation strategies: continuous irrigation (Cont), intermittent irrigation, with three fractions a day, at 1-hour intervals (Int1); intermittent irrigation, with three fractions a day, at 4-hour intervals (Int2) and two nitrogen doses (100 and 130 kg/ha N), in daily fertigation. Intermittent irrigation management strategies (Int1 and Int2) increased the contents and accumulation of dry matter and N, P, K, Ca, Mg, S, B, Fe, Mn and Zn. The dose of 130 kg/ha N only increased the content and accumulation of P and Mn in the first and second cycles, respectively. In general, lettuce accumulated macronutrients in the following decreasing order: K&gt;N&gt;Ca&gt;P&gt;Mg&gt;S, whereas micronutrients followed the order Fe&gt;Mn&gt;Zn&gt;B&gt;Cu. The treatments Int1, Int2 and 100 kg/ha N optimized the N use efficiency.
DOI: 10.6084/m9.figshare.21856209
title: Amlexanox Exhibits Cardioprotective Effects in 5/6 Nephrectomized Rats

description: Abstract Cardiorenal syndrome is a life-threatening condition. The aim of the current study was to determine the cardioprotective effects of amlexanox in 5/6 nephrectomized rats. Rats were randomly assigned to three groups: sham, 5/6 nephrectomized rats, and amlexanox-treated 5/6 nephrectomized group. Amlexanox (25 mg/kg/day, i.p.) administration was started just after surgery and continued for 10 weeks. After treatment, kidney function (serum creatinine and urea) and blood pressure (systolic and diastolic) were measured. Heart weight (normalized to tibial length) and fibrosis area percentage were measured. Serum brain natriuretic peptide (BNP, heart failure marker) and cardiac levels of β1-adrenergic receptor (β1AR), β-arrestin-2, phosphatidylinositol-4,5-bisphosphate (PIP2), diacylglycerol (DAG), pS473 Akt (a survival marker), and caspase-3 activity (an apoptosis marker) were also measured. The 5/6 nephrectomy caused renal impairment, cardiac fibrosis, apoptosis, and heart failure indicated by down- regulation of cardiac β1AR down-stream signals compared with those in the sham group. Interestingly, amlexanox significantly reduced all cardiopathological changes induced after 10 weeks of 5/6 nephrectomy. Amlexanox showed potent cardiac antifibrotic and antiapoptotic effects in 5/6 nephrectomized rats, which were associated with reduced heart failure. To our knowledge, this is the first study that addresses the potent in vivo cardioprotective effects of amlexanox.
DOI: 10.6084/m9.figshare.21856209.v1
title: Amlexanox Exhibits Cardioprotective Effects in 5/6 Nephrectomized Rats

description: Abstract Cardiorenal syndrome is a life-threatening condition. The aim of the current study was to determine the cardioprotective effects of amlexanox in 5/6 nephrectomized rats. Rats were randomly assigned to three groups: sham, 5/6 nephrectomized rats, and amlexanox-treated 5/6 nephrectomized group. Amlexanox (25 mg/kg/day, i.p.) administration was started just after surgery and continued for 10 weeks. After treatment, kidney function (serum creatinine and urea) and blood pressure (systolic and diastolic) were measured. Heart weight (normalized to tibial length) and fibrosis area percentage were measured. Serum brain natriuretic peptide (BNP, heart failure marker) and cardiac levels of β1-adrenergic receptor (β1AR), β-arrestin-2, phosphatidylinositol-4,5-bisphosphate (PIP2), diacylglycerol (DAG), pS473 Akt (a survival marker), and caspase-3 activity (an apoptosis marker) were also measured. The 5/6 nephrectomy caused renal impairment, cardiac fibrosis, apoptosis, and heart failure indicated by down- regulation of cardiac β1AR down-stream signals compared with those in the sham group. Interestingly, amlexanox significantly reduced all cardiopathological changes induced after 10 weeks of 5/6 nephrectomy. Amlexanox showed potent cardiac antifibrotic and antiapoptotic effects in 5/6 nephrectomized rats, which were associated with reduced heart failure. To our knowledge, this is the first study that addresses the potent in vivo cardioprotective effects of amlexanox.
DOI: 10.6084/m9.figshare.21856213
title: The effects of agomelatine in cisplatin-induced toxicity on the kidney and liver tissues: In vivo study

description: Abstract Nephrotoxicity and hepatotoxicity are frequently seen adverse effects during cisplatin chemotherapy. In this study, we investigated the effects of agomelatine on cisplatin-induced toxicity in the kidney and liver. Animals were administered with a single dose of cisplatin (7 mg/kg, i.p.) and treated with agomelatine (20 and 40 mg/kg, p.o) for seven days. Renal and hepatic functions were evaluated by measuring concentrations of creatinine, BUN, AST and ALT in the serum. Oxidative stress and protein peroxidation were assessed by measuring SOD, CAT, GSH and AOPP levels in both tissues. Serum PON-1 levels were also evaluated. Histopathological analysis was performed to determined structural changes in the kidney and liver. Agomelatine (20 mg/kg) treatment approximately halved cisplatin-related increase in serum creatinine, BUN, AST and ALT levels. Agomelatine (20 mg/kg) significantly prevented the cisplatin-induced excessive decrease in SOD, CAT, GSH in both tissues and serum PON-1 levels. Agomelatine (20 and 40 mg/kg) protected the structural integrity of the kidney against cisplatin-insult. Although agomelatine (40 mg/kg) protected the kidney and showed parallel results with 20 mg/kg biochemically, it failed to show the same liver tissue effects in both analyses. Although agomelatine protected against cisplatin-induced toxicity in the kidney and liver, care should be taken with higher doses for possible hepatotoxicity.