cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.3985497.v1
title: Table S1 from Snake fungal disease: an emerging threat to wild snakes

description: Samples used to determine the types of fungi associated with dermatitis in wild snakes. Location data are displayed only to the county (or sometimes state) level due to concerns with disclosing specific locations of rare or sensitive snake populations. Fungal infection was assessed by examining histologic sections of skin lesions. The number of gross lesions consistent with dermatitis were categorized as "none" (no gross skin lesions observed), "single" (one lesion), "multiple" (more than one discrete lesion), or "not assessed" (no information was available on the number of skin lesions present). The type of fungal growth medium upon which samples were cultured is listed as "DTM" (dermatophyte test medium) or "SD" (Sabouraud dextrose medium containing chloramphenicol and gentamycin). The number of unique internal transcribed spacer region DNA sequences identified per snake (or operational taxonomic units [OTUs] at 100% sequence identity) is listed. Samples originating from snakes cited in previous literature are specified
DOI: 10.6084/m9.figshare.3985494.v1
title: Genetic differences from Microevolutionary traits and comparative population genomics of the emerging pathogenic fungus <i>Cryptococcus gattii</i>

description: All genetic differences identified between VGIIc EJB52 and VGIIc EJB18
DOI: 10.7910/dvn/v1rjpf/oytrer
title: snk20150611_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.3985488
title: Supplementary Table 1 Bignell et al from Secondary metabolite arsenal of an opportunistic pathogenic fungus

description: Analysis A. fumigatus 293 genome
DOI: 10.6084/m9.figshare.3985485
title: Summary of variant calling from Microevolutionary traits and comparative population genomics of the emerging pathogenic fungus <i>Cryptococcus gattii</i>

description: Summary of variant calling from whole genome sequencing of 64 isolates of Cryptococcus gattii aligned to the nuclear genomes of VGIIa isolate R265
DOI: 10.7910/dvn/v1rjpf/bxesl3
title: snk20160207_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.3985485.v1
title: Summary of variant calling from Microevolutionary traits and comparative population genomics of the emerging pathogenic fungus <i>Cryptococcus gattii</i>

description: Summary of variant calling from whole genome sequencing of 64 isolates of Cryptococcus gattii aligned to the nuclear genomes of VGIIa isolate R265
DOI: 10.6084/m9.figshare.3985488.v1
title: Supplementary Table 1 Bignell et al from Secondary metabolite arsenal of an opportunistic pathogenic fungus

description: Analysis A. fumigatus 293 genome
DOI: 10.6084/m9.figshare.3985482
title: Modelling reduction in AIDS deaths Dec 2015 from Minimizing fungal disease deaths will allow the UNAIDS target of reducing annual AIDS deaths below 500 000 by 2020 to be realized

description: Deaths from AIDS (1 500 000 in 2013) have been falling more slowly than anticipated with improved access to antiretroviral therapy. Opportunistic infections account for most AIDS-related mortality, with a median age of death in the mid-30s. About 360 000 (24%) of AIDS deaths are attributed to tuberculosis. Fungal infections deaths in AIDS are estimated at more than 700 000 deaths (47%) annually. Rapid diagnostic tools and antifungal agents are available for these diseases and would likely have a major impact in reducing deaths. Scenarios for reduction of avoidable deaths were constructed based on published outcomes of the real-life impact of diagnostics and generic antifungal drugs to 2020. Annual deaths could fall for cryptococcal disease by 70 000, <i>Pneumocystis</i> pneumonia by 162 500, disseminated histoplasmosis by 48 000 and chronic pulmonary aspergillosis by 33 500, with approximately 60% coverage of diagnostics and antifungal agents. If factored in with the 90–90–90 campaign rollout and its effect, AIDS deaths could fall to 426 000 by 2020, with further reductions possible with increased coverage. Action could and should be taken by donors, national and international public health agencies, NGOs and governments to achieve the UNAIDS mortality reduction target, by scaling up capability to detect and treat fungal disease in AIDS.This article is part of the themed issue ‘Tackling emerging fungal threats to animal health, food security and ecosystem resilience’.
DOI: 10.7910/dvn/v1rjpf/ques81
title: snk20151023_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/ocnusr
title: snk20160817_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.3985482.v1
title: Modelling reduction in AIDS deaths Dec 2015 from Minimizing fungal disease deaths will allow the UNAIDS target of reducing annual AIDS deaths below 500 000 by 2020 to be realized

description: Deaths from AIDS (1 500 000 in 2013) have been falling more slowly than anticipated with improved access to antiretroviral therapy. Opportunistic infections account for most AIDS-related mortality, with a median age of death in the mid-30s. About 360 000 (24%) of AIDS deaths are attributed to tuberculosis. Fungal infections deaths in AIDS are estimated at more than 700 000 deaths (47%) annually. Rapid diagnostic tools and antifungal agents are available for these diseases and would likely have a major impact in reducing deaths. Scenarios for reduction of avoidable deaths were constructed based on published outcomes of the real-life impact of diagnostics and generic antifungal drugs to 2020. Annual deaths could fall for cryptococcal disease by 70 000, <i>Pneumocystis</i> pneumonia by 162 500, disseminated histoplasmosis by 48 000 and chronic pulmonary aspergillosis by 33 500, with approximately 60% coverage of diagnostics and antifungal agents. If factored in with the 90–90–90 campaign rollout and its effect, AIDS deaths could fall to 426 000 by 2020, with further reductions possible with increased coverage. Action could and should be taken by donors, national and international public health agencies, NGOs and governments to achieve the UNAIDS mortality reduction target, by scaling up capability to detect and treat fungal disease in AIDS.This article is part of the themed issue ‘Tackling emerging fungal threats to animal health, food security and ecosystem resilience’.
DOI: 10.6084/m9.figshare.3985482.v2
title: Modelling reduction in AIDS deaths Dec 2015 from Minimizing fungal disease deaths will allow the UNAIDS target of reducing annual AIDS deaths below 500 000 by 2020 to be realized

description: Deaths from AIDS (1 500 000 in 2013) have been falling more slowly than anticipated with improved access to antiretroviral therapy. Opportunistic infections account for most AIDS-related mortality, with a median age of death in the mid-30s. About 360 000 (24%) of AIDS deaths are attributed to tuberculosis. Fungal infections deaths in AIDS are estimated at more than 700 000 deaths (47%) annually. Rapid diagnostic tools and antifungal agents are available for these diseases and would likely have a major impact in reducing deaths. Scenarios for reduction of avoidable deaths were constructed based on published outcomes of the real-life impact of diagnostics and generic antifungal drugs to 2020. Annual deaths could fall for cryptococcal disease by 70 000, <i>Pneumocystis</i> pneumonia by 162 500, disseminated histoplasmosis by 48 000 and chronic pulmonary aspergillosis by 33 500, with approximately 60% coverage of diagnostics and antifungal agents. If factored in with the 90–90–90 campaign rollout and its effect, AIDS deaths could fall to 426 000 by 2020, with further reductions possible with increased coverage. Action could and should be taken by donors, national and international public health agencies, NGOs and governments to achieve the UNAIDS mortality reduction target, by scaling up capability to detect and treat fungal disease in AIDS.This article is part of the themed issue ‘Tackling emerging fungal threats to animal health, food security and ecosystem resilience’.
DOI: 10.7910/dvn/v1rjpf/jlgkya
title: snk20150531_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/nrd9bp
title: snk20161208_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/9agmup
title: snk20150215_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.3985443
title: ESM5_electrochemistry from Organosilane-functionalization of nanostructured indium tin oxide films

description: Cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS) data for bare as-deposited and GOPTS-coated ITO films
DOI: 10.7910/dvn/v1rjpf/volpxe
title: snk20160105_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.3985443.v1
title: ESM5_electrochemistry from Organosilane-functionalization of nanostructured indium tin oxide films

description: Cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS) data for bare as-deposited and GOPTS-coated ITO films
DOI: 10.6084/m9.figshare.3985437
title: ESM1_as-dep_nanostructuredITO from Organosilane-functionalization of nanostructured indium tin oxide films

description: XPS data for bare as-deposited nanostructured ITO surfaces
DOI: 10.6084/m9.figshare.3985440
title: ESM3_annealed_nanostructuredITO from Organosilane-functionalization of nanostructured indium tin oxide films

description: XPS data for bare anealed nanostructured ITO surfaces
DOI: 10.7910/dvn/v1rjpf/sufbbo
title: snk20150628_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.3985437.v1
title: ESM1_as-dep_nanostructuredITO from Organosilane-functionalization of nanostructured indium tin oxide films

description: XPS data for bare as-deposited nanostructured ITO surfaces
DOI: 10.6084/m9.figshare.3985440.v1
title: ESM3_annealed_nanostructuredITO from Organosilane-functionalization of nanostructured indium tin oxide films

description: XPS data for bare anealed nanostructured ITO surfaces
DOI: 10.6084/m9.figshare.3985434
title: ESM4_annealed_nanostructuredITO-GOPTS from Organosilane-functionalization of nanostructured indium tin oxide films

description: XPS data for GOPTS-coated annealed nanostructured ITO surfaces
DOI: 10.7910/dvn/v1rjpf/o6jrsb
title: snk20161217_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.3985434.v1
title: ESM4_annealed_nanostructuredITO-GOPTS from Organosilane-functionalization of nanostructured indium tin oxide films

description: XPS data for GOPTS-coated annealed nanostructured ITO surfaces
DOI: 10.7910/dvn/v1rjpf/hhk6jc
title: snk20150624_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/fqpbzn
title: snk20160420_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.3985422
title: ESM2_as-dep_nanostructuredITO-GOPTS from Organosilane-functionalization of nanostructured indium tin oxide films

description: XPS data for GOPTS-coated as-deposited nanostructured ITO surfaces
DOI: 10.7910/dvn/v1rjpf/l2imfq
title: snk20160408_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.3985410
title: Survival is predicted by territorial status but not wing pigmentation in males of a polythorid damselfly, <i>Euthore fasciata</i> (Odonata: Zygoptera: Polythoridae)

description: Robust male condition must be favored and should be signaled to conspecifics via enhanced aggression and more highly expressed ornamental traits. One way that such robust condition, and thereby the expression of aggression and ornamental traits, can be assessed is via survival. In odonate adults, condition (in the form of lipid reserves, muscle mass and immune ability) has been correlated with the expression of: (a) territorial behavior (as opposed to nonterritorial, satellite behavior), and (b) larger wing pigmentation patterns. In the present work, we investigated these two patterns using adult males of <i>Euthore fasciata</i> in a field study. Males bear black and white pigmented wing patterns and express territorial and nonterritorial behaviors to secure matings. We predicted that, due to their better condition, territorial males should have higher survival and larger pigmented patterns than nonterritorial males, and that larger pigmented patterns would correlate positively with survival. We marked–recaptured males, measured their pigmented patterns and recorded their behavior. Our results indicated that territorial males (<i>n</i> = 12) had a higher survival, but not larger pigmented areas, than nonterritorial males (<i>n</i> = 39), and that there was no significant relationship between wing pigmentation and survival. This result confirms that territorial males are in better condition than nonterritorial males. However, wing pigmentation does not seem to signal such condition to conspecifics although the reduced number of animals may have affected our analysis. Tentatively, the assumed relationship pigmentation/condition cannot be generalized in odonates.
DOI: 10.7910/dvn/v1rjpf/ueovlr
title: snk20151220_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.3985383
title: Supplementary Material for: Intravenous Immunoglobulins Lower Inflammatory Gene Expression in Skin Biopsies of Chronic Inflammatory Demyelinating Polyradiculoneuropathy Patients

description: No Abstracts
DOI: 10.6084/m9.figshare.3985410.v1
title: Survival is predicted by territorial status but not wing pigmentation in males of a polythorid damselfly, <i>Euthore fasciata</i> (Odonata: Zygoptera: Polythoridae)

description: Robust male condition must be favored and should be signaled to conspecifics via enhanced aggression and more highly expressed ornamental traits. One way that such robust condition, and thereby the expression of aggression and ornamental traits, can be assessed is via survival. In odonate adults, condition (in the form of lipid reserves, muscle mass and immune ability) has been correlated with the expression of: (a) territorial behavior (as opposed to nonterritorial, satellite behavior), and (b) larger wing pigmentation patterns. In the present work, we investigated these two patterns using adult males of <i>Euthore fasciata</i> in a field study. Males bear black and white pigmented wing patterns and express territorial and nonterritorial behaviors to secure matings. We predicted that, due to their better condition, territorial males should have higher survival and larger pigmented patterns than nonterritorial males, and that larger pigmented patterns would correlate positively with survival. We marked–recaptured males, measured their pigmented patterns and recorded their behavior. Our results indicated that territorial males (<i>n</i> = 12) had a higher survival, but not larger pigmented areas, than nonterritorial males (<i>n</i> = 39), and that there was no significant relationship between wing pigmentation and survival. This result confirms that territorial males are in better condition than nonterritorial males. However, wing pigmentation does not seem to signal such condition to conspecifics although the reduced number of animals may have affected our analysis. Tentatively, the assumed relationship pigmentation/condition cannot be generalized in odonates.
DOI: 10.7910/dvn/v1rjpf/biknrn
title: snk20150127_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.3985353
title: Data for report on offset agreements

description: This dataset contains details of article processing charges paid by UK universities in 2015. It was used as the basis of the report 'Report on offset agreements: evaluating current Jisc Collections deals. Year 1 – evaluating 2015 deals' published on 24 October 2016.<br><br>All data within has been previously published.<br>
DOI: 10.7910/dvn/v1rjpf/wrltey
title: snk20151029_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/nfhisk
title: snk20150505_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/dewhey
title: snk20160924_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/wx19vs
title: snk20160330_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/exiwmd
title: snk20160417_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.3985230
title: Supplementary Material for: Frequency and Determinants of Adherence to Oral Anticoagulants in Stroke Patients with Atrial Fibrillation in Clinical Practice

description: <b><i>Background:</i></b> Vitamin K antagonists (VKAs) and non-VKA oral anticoagulants (NOACs) are beneficial in patients with stroke and atrial fibrillation (AF). However, little is known about frequency and determinants of adherence to NOACs/VKAs in clinical practice. <b><i>Methods:</i></b> This is a single-center explorative study from the Novel Oral Anticoagulants in Stroke Patients (NOACISP)-LONGTERM registry. We included consecutive AF-stroke patients treated with NOACs/VKAs and followed up for 3-24 months. Adherence was assessed at follow-up using structured interviews and quantified as the proportion of prescribed doses taken (PDT). Outcome measures were (i) full adherence, (ii) ≥95% adherence and (iii) ≥80% adherence (i.e., PDT 100/≥95/≥80%). To explore determinants of full adherence, we compared characteristics of fully and non-fully adherent patients. <b><i>Results:</i></b> A total of 218 of 251 (86.9%) patients (48% female, mean age 77.9 ± 9.1 years, 78% NOACs; 22% VKAs) were eligible for analysis with a median follow-up of 12 months: fully adherent were 78.4% patients (NOACs 77.1%, VKAs 83.3%, p = 0.35), ≥95% adherent were 95.4% and ≥80% adherent were 97.2%. Fully adherent patients took more pills daily (median (interquartile range) 7 (5-10) vs. 6 (4-8), p = 0.039), had more often previous antithrombotic treatment (70.8 vs. 53.2%, p = 0.023), caregiver-assisted medication administration (54.2 vs. 19.1%, p &lt; 0.001) and functional dependency (32.8 vs. 15%, p = 0.011) than non-fully adherent patients. <b><i>Conclusions:</i></b> Full adherence was frequent. Patients naïve to antithrombotics, taking few pills, which they self-administer, were at the highest risk of non-adherence and may benefit most from adherence-enhancing interventions.
DOI: 10.7910/dvn/v1rjpf/apymtj
title: snk20151108_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.3985179
title: Supplementary Material for: The Body Acoustic: Ultrasonic Neuromodulation for Translational Medicine

description: For the greater part of the last century, ultrasound (US) has seen widespread use in applications ranging from materials science to medicine. The history of US in medicine has also seen promising success in clinical diagnostics and regenerative medicine. Recent studies have shown that US is able to manipulate the nervous system, leading toward potential treatment for various neuropathological conditions, a phenomenon known as ultrasonic neuromodulation (NM). Ultrasonic NM is a promising alternative to pharmaceuticals and surgery, due to high spatiotemporal resolution combined with the potentially noninvasive means of application. Current advances have made progress in establishing effective dosage limits, waveform parameters, and stimulus regimes in order to achieve desired effects in a variety of tissue and cell types. However, to date there has been limited systematic analysis of the complex variables involved in creating a therapeutic US stimulation regime specifically tailored to the nervous system. Without a fundamental understanding of the effects of US on neural tissue, including the surrounding bone, musculature, and vasculature, the safety and efficacy of US as an NM tool is yet to be determined. Advances in imaging technology and focusing hardware highlight new avenues for potential clinical applications for therapeutic ultrasonic stimulation. US may be an alternative to electrical and magnetic means of NM for targets in the central nervous system as well as in the peripheral and autonomic nervous systems. This review provides a historical perspective on the past, present, and future of US as a translational therapeutic.
DOI: 10.6084/m9.figshare.3985200
title: Supplementary Material for: Prolonged Treatment of Peanut-Allergic Mice with Bortezomib Significantly Reduces Serum Anti-Peanut IgE but Does Not Affect Allergic Symptoms

description: <b><i>Background:</i></b> Anti-peanut immunoglobulin E (anti-Pn IgE) can persist throughout life, suggesting that this condition could be maintained by long-lived antibody-secreting cells (ASCs). To determine the role of long-lived ASCs, peanut-allergic mice underwent prolonged treatment with the proteasome inhibitor, bortezomib (Bz). <b><i>Methods:</i></b> Intravenous Bz was given twice weekly for 21 weeks to peanut-allergic mice. During treatment, serum anti-Pn IgE was measured, and the mice were rechallenged at the end of treatment. Cell populations were measured, and Pn-specific IgG, total IgG, and total IgE ASCs were enumerated in the bone marrow (BM) and spleen (SPL). <b><i>Results:</i></b> Prolonged treatment with Bz significantly reduced serum anti-Pn IgE and IgG1 but did not affect symptoms following challenge with Pn, even in mice with undetectable serum anti-Pn IgE. Numbers of CD138+ cells were significantly reduced in the BM but were unaffected in the SPL. Unexpectedly, Bz did not affect numbers of Pn-specific IgG, total IgG, or total IgE ASCs in either the BM or SPL. <b><i>Conclusions:</i></b> Cells that maintain long-lived serum anti-Pn IgE are sensitive to Bz. However, prolonged depletion of serum Pn-specific IgE does not result in a decrease of symptoms following challenge with Pn.
DOI: 10.6084/m9.figshare.3985200.v1
title: Supplementary Material for: Prolonged Treatment of Peanut-Allergic Mice with Bortezomib Significantly Reduces Serum Anti-Peanut IgE but Does Not Affect Allergic Symptoms

description: <b><i>Background:</i></b> Anti-peanut immunoglobulin E (anti-Pn IgE) can persist throughout life, suggesting that this condition could be maintained by long-lived antibody-secreting cells (ASCs). To determine the role of long-lived ASCs, peanut-allergic mice underwent prolonged treatment with the proteasome inhibitor, bortezomib (Bz). <b><i>Methods:</i></b> Intravenous Bz was given twice weekly for 21 weeks to peanut-allergic mice. During treatment, serum anti-Pn IgE was measured, and the mice were rechallenged at the end of treatment. Cell populations were measured, and Pn-specific IgG, total IgG, and total IgE ASCs were enumerated in the bone marrow (BM) and spleen (SPL). <b><i>Results:</i></b> Prolonged treatment with Bz significantly reduced serum anti-Pn IgE and IgG1 but did not affect symptoms following challenge with Pn, even in mice with undetectable serum anti-Pn IgE. Numbers of CD138+ cells were significantly reduced in the BM but were unaffected in the SPL. Unexpectedly, Bz did not affect numbers of Pn-specific IgG, total IgG, or total IgE ASCs in either the BM or SPL. <b><i>Conclusions:</i></b> Cells that maintain long-lived serum anti-Pn IgE are sensitive to Bz. However, prolonged depletion of serum Pn-specific IgE does not result in a decrease of symptoms following challenge with Pn.
DOI: 10.7910/dvn/v1rjpf/uyvea9
title: snk20160424_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/zt2lxo
title: snk20150319_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/p6lhwf
title: snk20150621_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/hipl1h
title: snk20160619_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/ypfjnt
title: snk20160904_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/57a3de
title: snk20160407_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/skt4yv
title: snk20160902_03.txt.gz

description: :unav