cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.15468/dl.uncgg3
title: Occurrence Download

description: A dataset containing 40 species occurrences available in GBIF matching the query:
{
 "and" : [
 "GbifId is one of (1262860326, 3880702157, 1833651391, 1809676337, 1833651725, 3880701651, 1460515312, 3436885921, 1262783035, 3436943087, 447270711, 211235266, 211235267, 2001275119, 1458597709, 1706986878, 1707081479, 1999762366, 2001568010, 2001275074, 1414924260, 1414816130, 3347430059, 1986118128, 1986084367, 1984575190, 1984965714, 1986280542, 1984421490, 1985984927, 1984657178, 1986084111, 1984556899, 1985962598, 4060044397, 3899058157, 4898729482, 4898905253, 4898849695, 2848625819)",
 "TaxonKey is Gyrophaena williamsi"
 ]
}

 The dataset includes 40 records from 15 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0053745-251120083545085/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.17026/dans-zk8-zpx7
title: De Nederlandse Dialectenbank, voorheen Soundbites - Transcripties (niet geanonimiseerd)

description: &lt;p&gt;De Nederlandse Dialectenbank, voorheen Soundbites, bevat meer dan duizend uur geluidsmateriaal, zoals dit in de afgelopen decennia is verzameld door onderzoekers van het Meertens Instituut (KNAW).&lt;/p&gt;&lt;p&gt;Het betreft geluidsbestanden van dialectopnames van binnen en buiten Europa. Het leeuwendeel van de Europese opnames is afkomstig uit het Nederlandse taalgebied: Nederland, Vlaanderen en Noord-Frankrijk. De opnames van buiten Europa, zoals uit de Verenigde Staten, zijn meestal van Nederlandse emigranten. Bij veel opnames is documentatie beschikbaar, zoals transcripties, gegevens over de sprekers en vragenlijsten.&lt;/p&gt;&lt;p&gt;De data van de Nederlandse Dialectenbank is verdeeld over meerdere datasets:&lt;br&gt;- de transcripties, zowel niet-geanonimiseerd (op aanvraag beschikbaar) als geanonimiseerd (direct te downloaden voor ingelogde gebruikers)&lt;br&gt;- de stamboeken Vrije Gesprekken (projectdocumentatie van de interviews in Europa, op aanvraag beschikbaar)&lt;br&gt;- de aantekeningen van taalkundige Jo Daan (projectdocumentatie van de interviews in de Verenigde Staten, op aanvraag beschikbaar)&lt;/p&gt;&lt;p&gt;Op de website van het Meertens Instituut kunt u de hele collectie doorzoeken of gebruik maken van de zoekmogelijkheden van de Sprekende Kaart.&lt;/p&gt;&lt;p&gt;Transcripties De Nederlandse Dialectenbank, niet geanonimiseerd&lt;/p&gt;&lt;p&gt;Naast geluidsfragmenten bezit het Meertens Instituut transcripties behorende bij de geluidsfragmenten. Deze transcripties zijn gemaakt tussen 1955 en 1973 (Meertens Instituut, Archiefnummer 62). De typoscripten zijn gescand en gedigitaliseerd. In totaal gaat het om meer dan 11.000 scans. De transcripties zijn beschikbaar als JPEG (geanonimiseerd) en als TIFF.&lt;/p&gt;&lt;p&gt;Deze dataset betreft de niet-geanonimiseerde data in het formaat TIFF. Zie het veld 'Relations' voor de koppeling naar de dataset met de geanonimiseerde, vrij toegankelijke data.&lt;/p&gt;
description: Date Submitted: 2013-05-23
description: &lt;p&gt;De indeling van de bestanden berust op de Kloeke-nummering zoals ook gebruikt in de Sprekende Kaart op de website van De Nederlandse Dialectenbank.&lt;/p&gt;
DOI: 10.18150/e8kvwo
title: Dane do publikacji: "Beneath the sand: Microbiota composition across instars of two co-occurring antlion species"

description: Zbiór danych zawiera listę próbek zebranych w ramach publikacji "Beneath the sand: Microbiota composition across instars of two co-occurring antlion species", wraz z metadanymi (informacje o lokalizacji, dacie zbioru itd.) oraz wyliczonymi wartościami dotyczącymi alfa- i beta- miar różnorodności (plik: 01-Antlion-samples-data-alpha-beta) oraz pliki z wynikami analiz dotyczących różnic w częstości występowania poszczególnych rodzajów lub wariantów bakterii (DESeq2, pliki 02-03) wraz z plikiem zawierającym opisy kolumn w wynikach DESeq2 (plik Legend-for-DESeq2-files).
DOI: 10.15468/dl.s8hzjx
title: Occurrence Download

description: A dataset containing 2250 species occurrences available in GBIF matching the query:
{
 "and" : [
 "BasisOfRecord is one of (Specimen, Human Observation)",
 "Country is Colombia",
 "TaxonKey is Aedes aegypti"
 ]
}

 The dataset includes 2250 records from 8 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0053747-251120083545085/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.q8dcbx
title: Occurrence Download

description: A dataset listing the 1 species recorded in GBIF matching the query:
{
 "and" : [
 "Country is Gabon",
 "TaxonKey is Aucoumea klaineana"
 ]
}

 The dataset's 1 records were derived from 24 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0053741-251120083545085/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.13130/rd_unimi/cpqdte/2nnk7x
title: Novembre_1929_Pagina_105.jpg

description: Bulletin of 1929/11/27
DOI: 10.13130/rd_unimi/cpqdte/oti2bh
title: Novembre_1929_Pagina_106.jpg

description: Bulletin of 1929/11/27
DOI: 10.13130/rd_unimi/cpqdte/l7alke
title: Novembre_1929_Pagina_107.jpg

description: Bulletin of 1929/11/27
DOI: 10.13130/rd_unimi/cpqdte/f3o14j
title: Novembre_1929_Pagina_108.jpg

description: Bulletin of 1929/11/27
DOI: 10.13130/rd_unimi/cpqdte/ji8iiy
title: Novembre_1929_Pagina_109.jpg

description: Bulletin of 1929/11/28
DOI: 10.5281/zenodo.17940805
title: Antibiotics Confound Breath-Based Respiratory Disease Detection in Calves - Dataset

description: This dataset supports the paper “Antibiotics Confound Breath-Based Respiratory Disease Detection in Calves” (PLOS ONE). It contains breath volatile organic compound (VOC) emission rates and clinical metadata collected from calves during two experimental phases:





Tab 1 – BRD Trial:Emission rates of individual VOCs measured in the breath of healthy and diseased calves using PTR-QiTOF (quadrupole ion guide). Units: µg animal⁻¹ h⁻¹, except formaldehyde (mg animal⁻¹ h⁻¹) and CO₂ (g animal⁻¹ h⁻¹). Metadata includes date/time, animal ID, health status, true disease classification, medications, respiration rate, rectal temperature, clinical scores (nose, eyes, ears, cough, total), and age.




Tab 2 – Antibiotic Trial:Breath emission rates for four VOCs before and after administration of Alamycin LA300, measured at –48 h, –24 h (baseline), and 1 h, 24 h, 48 h, 72 h, and 96 h post-treatment.



File format: Excel (.xlsx) with two tabs. Column headers include metadata and VOC formulas (protonated species).Instrument: Proton Transfer Reaction Time-of-Flight Mass Spectrometer (PTR-QiTOF).
DOI: 10.5281/zenodo.17940806
title: Antibiotics Confound Breath-Based Respiratory Disease Detection in Calves - Dataset

description: This dataset supports the paper “Antibiotics Confound Breath-Based Respiratory Disease Detection in Calves” (PLOS ONE). It contains breath volatile organic compound (VOC) emission rates and clinical metadata collected from calves during two experimental phases:





Tab 1 – BRD Trial:Emission rates of individual VOCs measured in the breath of healthy and diseased calves using PTR-QiTOF (quadrupole ion guide). Units: µg animal⁻¹ h⁻¹, except formaldehyde (mg animal⁻¹ h⁻¹) and CO₂ (g animal⁻¹ h⁻¹). Metadata includes date/time, animal ID, health status, true disease classification, medications, respiration rate, rectal temperature, clinical scores (nose, eyes, ears, cough, total), and age.




Tab 2 – Antibiotic Trial:Breath emission rates for four VOCs before and after administration of Alamycin LA300, measured at –48 h, –24 h (baseline), and 1 h, 24 h, 48 h, 72 h, and 96 h post-treatment.



File format: Excel (.xlsx) with two tabs. Column headers include metadata and VOC formulas (protonated species).Instrument: Proton Transfer Reaction Time-of-Flight Mass Spectrometer (PTR-QiTOF).
DOI: 10.13130/rd_unimi/cpqdte/b9jeza
title: Novembre_1929_Pagina_110.jpg

description: Bulletin of 1929/11/28
DOI: 10.13130/rd_unimi/cpqdte/jzjiqb
title: Novembre_1929_Pagina_111.jpg

description: Bulletin of 1929/11/28
DOI: 10.13130/rd_unimi/cpqdte/hewnnq
title: Novembre_1929_Pagina_112.jpg

description: Bulletin of 1929/11/28
DOI: 10.13130/rd_unimi/cpqdte/45pog6
title: Novembre_1929_Pagina_113.jpg

description: Bulletin of 1929/11/29
DOI: 10.6084/m9.figshare.30053503
title: OIC2025_manuf_challenge_targetT0.csv

description: Supplement
DOI: 10.6084/m9.figshare.30053503.v1
title: OIC2025_manuf_challenge_targetT0.csv

description: Supplement
DOI: 10.6084/m9.figshare.30053506
title: OIC2025_manuf_challenge_targetR1.csv

description: Supplement
DOI: 10.6084/m9.figshare.30053509
title: OIC2025_manuf_challenge_targetR2.csv

description: Supplement
DOI: 10.13130/rd_unimi/cpqdte/dglomu
title: Novembre_1929_Pagina_114.jpg

description: Bulletin of 1929/11/29
DOI: 10.6084/m9.figshare.30053506.v1
title: OIC2025_manuf_challenge_targetR1.csv

description: Supplement
DOI: 10.6084/m9.figshare.30053509.v1
title: OIC2025_manuf_challenge_targetR2.csv

description: Supplement
DOI: 10.13130/rd_unimi/cpqdte/2sihun
title: Novembre_1929_Pagina_115.jpg

description: Bulletin of 1929/11/29
DOI: 10.13130/rd_unimi/cpqdte/jmm7xy
title: Novembre_1929_Pagina_116.jpg

description: Bulletin of 1929/11/29
DOI: 10.13130/rd_unimi/cpqdte/n73ug8
title: Novembre_1929_Pagina_117.jpg

description: Bulletin of 1929/11/30
DOI: 10.13130/rd_unimi/cpqdte/xmqbfv
title: Novembre_1929_Pagina_118.jpg

description: Bulletin of 1929/11/30
DOI: 10.13130/rd_unimi/cpqdte/wxis5l
title: Novembre_1929_Pagina_119.jpg

description: Bulletin of 1929/11/30
DOI: 10.13130/rd_unimi/cpqdte/km0yxh
title: Novembre_1929_Pagina_120.jpg

description: Bulletin of 1929/11/30
DOI: 10.13130/rd_unimi/cpqdte/rbzmrn
title: Ottobre_1929_Pagina_001.jpg

description: Bulletin of 1929/10/01
DOI: 10.13130/rd_unimi/cpqdte/xhvskf
title: Ottobre_1929_Pagina_002.jpg

description: Bulletin of 1929/10/01
DOI: 10.13130/rd_unimi/cpqdte/jyflvf
title: Ottobre_1929_Pagina_003.jpg

description: Bulletin of 1929/10/01
DOI: 10.13130/rd_unimi/cpqdte/twxuer
title: Ottobre_1929_Pagina_004.jpg

description: Bulletin of 1929/10/01
DOI: 10.13130/rd_unimi/cpqdte/dgba2p
title: Ottobre_1929_Pagina_006.jpg

description: Bulletin of 1929/10/02
DOI: 10.13130/rd_unimi/cpqdte/joadwc
title: Ottobre_1929_Pagina_005.jpg

description: Bulletin of 1929/10/02
DOI: 10.13130/rd_unimi/cpqdte/etmlpk
title: Ottobre_1929_Pagina_007.jpg

description: Bulletin of 1929/10/02
DOI: 10.13130/rd_unimi/cpqdte/mga7p7
title: Ottobre_1929_Pagina_008.jpg

description: Bulletin of 1929/10/02
DOI: 10.15468/dl.dth9r3
title: Occurrence Download

description: A dataset containing 2226 species occurrences available in GBIF matching the query:
{
 "and" : [
 "BasisOfRecord is one of (Specimen, Human Observation)",
 "Continent is South America",
 "Country is Colombia",
 "TaxonKey is Aedes aegypti"
 ]
}

 The dataset includes 2226 records from 6 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0053749-251120083545085/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.13130/rd_unimi/cpqdte/e3uosv
title: Ottobre_1929_Pagina_009.jpg

description: Bulletin of 1929/10/03
DOI: 10.13130/rd_unimi/cpqdte/1c7h0y
title: Ottobre_1929_Pagina_010.jpg

description: Bulletin of 1929/10/03
DOI: 10.13130/rd_unimi/cpqdte/9cucoe
title: Ottobre_1929_Pagina_011.jpg

description: Bulletin of 1929/10/03
DOI: 10.13130/rd_unimi/cpqdte/uvsqmr
title: Ottobre_1929_Pagina_012.jpg

description: Bulletin of 1929/10/03
DOI: 10.13130/rd_unimi/cpqdte/hg2xl2
title: Ottobre_1929_Pagina_013.jpg

description: Bulletin of 1929/10/04
DOI: 10.13130/rd_unimi/cpqdte/7vu0g0
title: Ottobre_1929_Pagina_014.jpg

description: Bulletin of 1929/10/04
DOI: 10.13130/rd_unimi/cpqdte/smeyst
title: Ottobre_1929_Pagina_015.jpg

description: Bulletin of 1929/10/04
DOI: 10.13130/rd_unimi/cpqdte/3xw6zj
title: Ottobre_1929_Pagina_016.jpg

description: Bulletin of 1929/10/04
DOI: 10.13130/rd_unimi/cpqdte/1bm1mc
title: Ottobre_1929_Pagina_017.jpg

description: Bulletin of 1929/10/05
DOI: 10.13130/rd_unimi/cpqdte/8yfiin
title: Ottobre_1929_Pagina_018.jpg

description: Bulletin of 1929/10/05
DOI: 10.13130/rd_unimi/cpqdte/qgllo6
title: Ottobre_1929_Pagina_019.jpg

description: Bulletin of 1929/10/05
DOI: 10.13130/rd_unimi/cpqdte/epxynm
title: Ottobre_1929_Pagina_020.jpg

description: Bulletin of 1929/10/05
DOI: 10.5281/zenodo.17940673
title: Extreme Supersaturation in Human Airways (ANSYS Fluent Dataset)

description: This dataset contains Computational Fluid Dynamics (CFD) simulation files for the study:"Unprecedented 400% Relative Humidity in Human Airways: A Paradigm Shift in Understanding Cold-Air Inhalation". 

 

The files include: 



ANSYS Fluent case (.cas.h5) and data (.dat.h5) for –20°C, 70% RH inhalation at t = 0.04 ..0.010 ... 0.020 s, 

CFD-Post state file (.cst) for visualization of temperature, absolute humidity, and RH > 400%, 

README with setup instructions.


 

All simulations were performed using the ANSYS Fluent 2023 R2 Student Version, which is freely available for academic use. The methodology is fully reproducible on a standard desktop computer in under 1 hour.
DOI: 10.13130/rd_unimi/cpqdte/ahuig5
title: Ottobre_1929_Pagina_021.jpg

description: Bulletin of 1929/10/06
DOI: 10.13130/rd_unimi/cpqdte/vrxyf7
title: Ottobre_1929_Pagina_022.jpg

description: Bulletin of 1929/10/06
DOI: 10.13130/rd_unimi/cpqdte/lte0sm
title: Ottobre_1929_Pagina_024.jpg

description: Bulletin of 1929/10/06
DOI: 10.13130/rd_unimi/cpqdte/x7vo4z
title: Ottobre_1929_Pagina_023.jpg

description: Bulletin of 1929/10/06
DOI: 10.13130/rd_unimi/cpqdte/jarhxa
title: Ottobre_1929_Pagina_025.jpg

description: Bulletin of 1929/10/07
DOI: 10.13130/rd_unimi/cpqdte/xkcm7t
title: Ottobre_1929_Pagina_026.jpg

description: Bulletin of 1929/10/07
DOI: 10.13130/rd_unimi/cpqdte/i3cdgw
title: Ottobre_1929_Pagina_027.jpg

description: Bulletin of 1929/10/07
DOI: 10.13130/rd_unimi/cpqdte/vef996
title: Ottobre_1929_Pagina_028.jpg

description: Bulletin of 1929/10/07
DOI: 10.34740/kaggle/dsv/14166179
title: BOS Kemdikbud
DOI: 10.13130/rd_unimi/cpqdte/c8ngnp
title: Ottobre_1929_Pagina_029.jpg

description: Bulletin of 1929/10/08
DOI: 10.13130/rd_unimi/cpqdte/muby1d
title: Ottobre_1929_Pagina_030.jpg

description: Bulletin of 1929/10/08
DOI: 10.13130/rd_unimi/cpqdte/trfh7n
title: Ottobre_1929_Pagina_031.jpg

description: Bulletin of 1929/10/08
DOI: 10.15468/dl.vxq6jg
title: Occurrence Download

description: A dataset containing 72444311 species occurrences available in GBIF matching the query:
{
 "and" : [
 "BasisOfRecord is Human Observation",
 "Country is Spain",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present"
 ]
}

 The dataset includes 72444311 records from 536 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0053698-251120083545085/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.13130/rd_unimi/cpqdte/k90fzg
title: Ottobre_1929_Pagina_032.jpg

description: Bulletin of 1929/10/08
DOI: 10.13130/rd_unimi/cpqdte/khmn5i
title: Ottobre_1929_Pagina_033.jpg

description: Bulletin of 1929/10/09
DOI: 10.5066/p9jps7it
title: Argon data for Tuvatu Gold Mine, Fiji

description: Ar/Ar data are for 1 sample that constrains the cooling age of biotite. The geochronology provides time constraints for the age of gold mineralization in the Tuvatu Gold Mine in Fiji. Samples were provided by Thomas Monecke (Colorado School of Mines). Samples were analyzed in January 2024.
DOI: 10.13130/rd_unimi/cpqdte/72trim
title: Ottobre_1929_Pagina_034.jpg

description: Bulletin of 1929/10/09
DOI: 10.13130/rd_unimi/cpqdte/lz7kyn
title: Ottobre_1929_Pagina_035.jpg

description: Bulletin of 1929/10/09
DOI: 10.13130/rd_unimi/cpqdte/zmpaua
title: Ottobre_1929_Pagina_036.jpg

description: Bulletin of 1929/10/09
DOI: 10.13130/rd_unimi/cpqdte/znndga
title: Ottobre_1929_Pagina_037.jpg

description: Bulletin of 1929/10/10
DOI: 10.13130/rd_unimi/cpqdte/7xkuol
title: Ottobre_1929_Pagina_038.jpg

description: Bulletin of 1929/10/10
DOI: 10.13130/rd_unimi/cpqdte/ewxypb
title: Ottobre_1929_Pagina_039.jpg

description: Bulletin of 1929/10/10
DOI: 10.13130/rd_unimi/cpqdte/lklehy
title: Ottobre_1929_Pagina_041.jpg

description: Bulletin of 1929/10/11
DOI: 10.13130/rd_unimi/cpqdte/x39rlq
title: Ottobre_1929_Pagina_040.jpg

description: Bulletin of 1929/10/10
DOI: 10.13130/rd_unimi/cpqdte/7fudd9
title: Ottobre_1929_Pagina_042.jpg

description: Bulletin of 1929/10/11
DOI: 10.13130/rd_unimi/cpqdte/zjz2ag
title: Ottobre_1929_Pagina_043.jpg

description: Bulletin of 1929/10/11
DOI: 10.13130/rd_unimi/cpqdte/mry9gu
title: Ottobre_1929_Pagina_044.jpg

description: Bulletin of 1929/10/11
DOI: 10.13130/rd_unimi/cpqdte/xw6ekh
title: Ottobre_1929_Pagina_045.jpg

description: Bulletin of 1929/10/12
DOI: 10.13130/rd_unimi/cpqdte/gzzjfv
title: Ottobre_1929_Pagina_046.jpg

description: Bulletin of 1929/10/12
DOI: 10.13130/rd_unimi/cpqdte/vrezls
title: Ottobre_1929_Pagina_047.jpg

description: Bulletin of 1929/10/12
DOI: 10.13130/rd_unimi/cpqdte/3kstbq
title: Ottobre_1929_Pagina_049.jpg

description: Bulletin of 1929/10/13
DOI: 10.13130/rd_unimi/cpqdte/lht7s1
title: Ottobre_1929_Pagina_048.jpg

description: Bulletin of 1929/10/12
DOI: 10.13130/rd_unimi/cpqdte/nouvil
title: Ottobre_1929_Pagina_050.jpg

description: Bulletin of 1929/10/13
DOI: 10.13130/rd_unimi/cpqdte/vfeliy
title: Ottobre_1929_Pagina_051.jpg

description: Bulletin of 1929/10/13
DOI: 10.13130/rd_unimi/cpqdte/lhxrqu
title: Ottobre_1929_Pagina_053.jpg

description: Bulletin of 1929/10/14
DOI: 10.13130/rd_unimi/cpqdte/ryxkkg
title: Ottobre_1929_Pagina_052.jpg

description: Bulletin of 1929/10/13
DOI: 10.13130/rd_unimi/cpqdte/74p6e2
title: Ottobre_1929_Pagina_054.jpg

description: Bulletin of 1929/10/14
DOI: 10.13130/rd_unimi/cpqdte/8tjes5
title: Ottobre_1929_Pagina_055.jpg

description: Bulletin of 1929/10/14
DOI: 10.13130/rd_unimi/cpqdte/ez3nvj
title: Ottobre_1929_Pagina_056.jpg

description: Bulletin of 1929/10/14
DOI: 10.13130/rd_unimi/cpqdte/bvfuil
title: Ottobre_1929_Pagina_057.jpg

description: Bulletin of 1929/10/15
DOI: 10.13130/rd_unimi/cpqdte/zz6in0
title: Ottobre_1929_Pagina_058.jpg

description: Bulletin of 1929/10/15
DOI: 10.13130/rd_unimi/cpqdte/yns6nh
title: Ottobre_1929_Pagina_059.jpg

description: Bulletin of 1929/10/15
DOI: 10.13130/rd_unimi/cpqdte/cbpbqn
title: Ottobre_1929_Pagina_060.jpg

description: Bulletin of 1929/10/15
DOI: 10.6084/m9.figshare.30885448
title: Hederagenin may promote functional recovery following spinal cord injury by modulating microglial polarization through the PPAR-γ signaling pathway

description: spinal cord injury (SCI) is a debilitating condition that can lead to severe motor deficits. This study aimed to evaluate the therapeutic effects of hederagenin, a Chinese herbal medicinal ingredient, on motor recovery and the inflammatory response in rat models of SCI. We used the Allen weight-drop technique to create a Sprague–Dawley rat model of spinal cord injury. We then administered hederagenin (10 mg/kg) via intraperitoneal injection for 28 consecutive days. Third-class first-class hospital. The Basso-Beattie-Bresnahan (BBB) scores were evaluated. Histological analyses were performed via hematoxylin and eosin staining. The levels of pro-inflammatory cytokines (IL-1β, IL-6, and TNF-α) in SCI rat spinal cord tissues were evaluated by immumohistochemical staining. Microglial activation markers (Iba-1) and M2 phenotypic markers (CD206) were assessed by Immunofluorescence staining. PPAR-γ in rats were assessed by western blotting (WB). The Basso-Beattie-Bresnahan (BBB) scoring system assessed locomotor function, and revealed significant improvements in BBB score in hederagenin-treated rats starting from the fifth day post-surgery. We also found elevated levels of pro-inflammatory cytokines (IL-1β, IL-6, and TNF-α) in the spinal cord tissues of SCI rats, which significantly decreased after hederagenin Treatment. We also analyzed Microglial activation markers were analyzed, including Iba-1. Our results showed increased expression of CD206 in response to hederagenin, indicating that it promotes M2 polarization and reduces microglial activation. Additionally, hederagenin increased the expression of peroxisome proliferator-activated receptor-γ (PPAR-γ) in rats with SCI. However, the PPAR-γ inhibitor GW966 reversed the above roles of hederagenin. Our results indicate that hederagenin not only aids in the recovery of motor function in SCI rats but also diminishes inflammation while fostering neuroprotection via the modulation of microglial activity. This effect may be linked to the activation of the PPAR-γ signaling pathway. These results provide compelling evidence for the potential of hederagenin as a therapeutic agent for SCI and warrant further investigation into its clinical applications in neuroregeneration and inflammation modulation.
DOI: 10.6084/m9.figshare.30885448.v1
title: Hederagenin may promote functional recovery following spinal cord injury by modulating microglial polarization through the PPAR-γ signaling pathway

description: spinal cord injury (SCI) is a debilitating condition that can lead to severe motor deficits. This study aimed to evaluate the therapeutic effects of hederagenin, a Chinese herbal medicinal ingredient, on motor recovery and the inflammatory response in rat models of SCI. We used the Allen weight-drop technique to create a Sprague–Dawley rat model of spinal cord injury. We then administered hederagenin (10 mg/kg) via intraperitoneal injection for 28 consecutive days. Third-class first-class hospital. The Basso-Beattie-Bresnahan (BBB) scores were evaluated. Histological analyses were performed via hematoxylin and eosin staining. The levels of pro-inflammatory cytokines (IL-1β, IL-6, and TNF-α) in SCI rat spinal cord tissues were evaluated by immumohistochemical staining. Microglial activation markers (Iba-1) and M2 phenotypic markers (CD206) were assessed by Immunofluorescence staining. PPAR-γ in rats were assessed by western blotting (WB). The Basso-Beattie-Bresnahan (BBB) scoring system assessed locomotor function, and revealed significant improvements in BBB score in hederagenin-treated rats starting from the fifth day post-surgery. We also found elevated levels of pro-inflammatory cytokines (IL-1β, IL-6, and TNF-α) in the spinal cord tissues of SCI rats, which significantly decreased after hederagenin Treatment. We also analyzed Microglial activation markers were analyzed, including Iba-1. Our results showed increased expression of CD206 in response to hederagenin, indicating that it promotes M2 polarization and reduces microglial activation. Additionally, hederagenin increased the expression of peroxisome proliferator-activated receptor-γ (PPAR-γ) in rats with SCI. However, the PPAR-γ inhibitor GW966 reversed the above roles of hederagenin. Our results indicate that hederagenin not only aids in the recovery of motor function in SCI rats but also diminishes inflammation while fostering neuroprotection via the modulation of microglial activity. This effect may be linked to the activation of the PPAR-γ signaling pathway. These results provide compelling evidence for the potential of hederagenin as a therapeutic agent for SCI and warrant further investigation into its clinical applications in neuroregeneration and inflammation modulation.
DOI: 10.13130/rd_unimi/cpqdte/cyp2ik
title: Ottobre_1929_Pagina_061.jpg

description: Bulletin of 1929/10/16
DOI: 10.13130/rd_unimi/cpqdte/ljuksr
title: Ottobre_1929_Pagina_062.jpg

description: Bulletin of 1929/10/16
DOI: 10.13130/rd_unimi/cpqdte/wzixrc
title: Ottobre_1929_Pagina_063.jpg

description: Bulletin of 1929/10/16
DOI: 10.13130/rd_unimi/cpqdte/bssa8n
title: Ottobre_1929_Pagina_064.jpg

description: Bulletin of 1929/10/16
DOI: 10.13130/rd_unimi/cpqdte/dzd98r
title: Ottobre_1929_Pagina_065.jpg

description: Bulletin of 1929/10/17