cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.20847214
title: Inguinal hernia in southern Brazil - challenges in follow-up and recurrence rates

description: ABSTRACT Introduction: recurrence rates for primary hernia repair range from 0.5 to 15 percent depending upon the hernia site, type of repair, and clinical circumstances. Many risk factors are known and they must be considered before the procedure. In developing countries, follow up and maintenance of databases are critical to understand the real numbers. Methods: a retrospective cohort study analyzed adult patients who have undergone inguinal hernia repair at Hospital de Clínicas de Porto Alegre, a tertiary care government public hospital, between 2013 and 2015. Medical records, telephone, and letter contact have been reviewed in order to complete the minimum period of 5 years of follow-up. The analyzed data focused on the surgeon’s experience and the recurrence rate in 5 years of follow-up. Results: a total of 1094 medical records were selected and a complete five years follow-up were possible in 454 patients - 538 inguinal hernia repairs due to bilateral approach in 84 patients. These 454 patients answered, in a validated questionnaire about symptoms of recurrence. The total recurrence rate was 9.29%. For the patients who had Nyhus IV, recurrence rate was 24.1% against 9.9% after primary hernia repair, with a 2.4 higher risk. There was no difference in recurrence between surgeons and training surgeons. Conclusion: our data reveal an acceptable recurrence rate in a tertiary care hospital with residents, and to our knowledge is the first Brazilian report with long term follow up. An increased re-recurrent hernia was found when compared with primary hernia repair.
DOI: 10.6084/m9.figshare.20847214.v1
title: Inguinal hernia in southern Brazil - challenges in follow-up and recurrence rates

description: ABSTRACT Introduction: recurrence rates for primary hernia repair range from 0.5 to 15 percent depending upon the hernia site, type of repair, and clinical circumstances. Many risk factors are known and they must be considered before the procedure. In developing countries, follow up and maintenance of databases are critical to understand the real numbers. Methods: a retrospective cohort study analyzed adult patients who have undergone inguinal hernia repair at Hospital de Clínicas de Porto Alegre, a tertiary care government public hospital, between 2013 and 2015. Medical records, telephone, and letter contact have been reviewed in order to complete the minimum period of 5 years of follow-up. The analyzed data focused on the surgeon’s experience and the recurrence rate in 5 years of follow-up. Results: a total of 1094 medical records were selected and a complete five years follow-up were possible in 454 patients - 538 inguinal hernia repairs due to bilateral approach in 84 patients. These 454 patients answered, in a validated questionnaire about symptoms of recurrence. The total recurrence rate was 9.29%. For the patients who had Nyhus IV, recurrence rate was 24.1% against 9.9% after primary hernia repair, with a 2.4 higher risk. There was no difference in recurrence between surgeons and training surgeons. Conclusion: our data reveal an acceptable recurrence rate in a tertiary care hospital with residents, and to our knowledge is the first Brazilian report with long term follow up. An increased re-recurrent hernia was found when compared with primary hernia repair.
DOI: 10.6084/m9.figshare.20847235
title: Leaf extract of Coffea arabica L. reduces lipid peroxidation and has anti-platelet effect in a rat dyslipidemia model

description: Abstract This study aimed to evaluate the antioxidant potential of the Coffea arabica Lineu (L.) leaf extract and its effects on platelet aggregation of dyslipidemic rats. The extract was obtained by the percolation of C. arabica L. leaves in hydroethanolic solution 70% (v/v). The mass spectrometry FIA-ESI-MS² suggested the presence of chlorogenic acid, rutin acid, and quinic acid. The DPPH• radicals scavenging capacity was demonstrated (IC50 = 0.06 mg/mL). The extract was administered to rats by gavage (300 mg/kg/day) for 56 days. Dyslipidemia was induced by administering Triton WR-1339 (300 mg/kg body weight) on the 54th day. On day 56, blood was collected by puncturing the abdominal aorta artery and the aortic artery was removed. Lipid profile, markers of renal and hepatic injury, lipid peroxidation, and platelet aggregation tests were carried out. The ingestion of extract reduced the lipid peroxidation (aorta and plasma) and platelet aggregation in dyslipidemic rats. The extract did not affect markers of renal and hepatic function as analyzed in this study, suggesting neither impaired liver nor kidney function in these animals. Therefore, our results demonstrate that the extract of leaves of C. arabica L. show antioxidant potential in vitro and in vivo as well as anti-platelet aggregation in dyslipidemic animals.
DOI: 10.6084/m9.figshare.20847235.v1
title: Leaf extract of Coffea arabica L. reduces lipid peroxidation and has anti-platelet effect in a rat dyslipidemia model

description: Abstract This study aimed to evaluate the antioxidant potential of the Coffea arabica Lineu (L.) leaf extract and its effects on platelet aggregation of dyslipidemic rats. The extract was obtained by the percolation of C. arabica L. leaves in hydroethanolic solution 70% (v/v). The mass spectrometry FIA-ESI-MS² suggested the presence of chlorogenic acid, rutin acid, and quinic acid. The DPPH• radicals scavenging capacity was demonstrated (IC50 = 0.06 mg/mL). The extract was administered to rats by gavage (300 mg/kg/day) for 56 days. Dyslipidemia was induced by administering Triton WR-1339 (300 mg/kg body weight) on the 54th day. On day 56, blood was collected by puncturing the abdominal aorta artery and the aortic artery was removed. Lipid profile, markers of renal and hepatic injury, lipid peroxidation, and platelet aggregation tests were carried out. The ingestion of extract reduced the lipid peroxidation (aorta and plasma) and platelet aggregation in dyslipidemic rats. The extract did not affect markers of renal and hepatic function as analyzed in this study, suggesting neither impaired liver nor kidney function in these animals. Therefore, our results demonstrate that the extract of leaves of C. arabica L. show antioxidant potential in vitro and in vivo as well as anti-platelet aggregation in dyslipidemic animals.
DOI: 10.6084/m9.figshare.20847247
title: Panorama of the water supply in the Campinas region and a brief comparison with other regions in the Southeast of Brazil

description: Abstract Access to drinking water is one of the most important factors for health. The lack of access to safe drinking water results in a high prevalence of infections, such as bacterial gastroenteritis and outbreaks of diarrhea. This study evaluated the quality of the public water supply in 42 municipalities located in the eastern region of the State of São Paulo, Brazil, from 2016 to 2020. Physical, chemical, and microbiological parameters were investigated. Sample collection, preservation and analyses were carried out in accordance with national and international standards. The results demonstrated non-compliance with Brazilian legislation for apparent color (1.1%), turbidity (0.4%), fluoride content (14.2%), total coliforms (4.4%) and Escherichia coli (E. coli) (0.4%). In a brief comparison with other studies in the southeastern region of Brazil, the highest percentage of unsatisfactory samples is due to the fact that fluorine is below the minimum of &lt;0.6 ppm, demonstrating the need for training in the fluoridation process. The need to invest in the training of health surveillance teams to carry out field analyses (chlorine and pH) was also observed. This study can inform future actions, guiding the adoption of preventive and corrective measures and demonstrating the importance of monitoring water-supply quality.
DOI: 10.6084/m9.figshare.20847247.v1
title: Panorama of the water supply in the Campinas region and a brief comparison with other regions in the Southeast of Brazil

description: Abstract Access to drinking water is one of the most important factors for health. The lack of access to safe drinking water results in a high prevalence of infections, such as bacterial gastroenteritis and outbreaks of diarrhea. This study evaluated the quality of the public water supply in 42 municipalities located in the eastern region of the State of São Paulo, Brazil, from 2016 to 2020. Physical, chemical, and microbiological parameters were investigated. Sample collection, preservation and analyses were carried out in accordance with national and international standards. The results demonstrated non-compliance with Brazilian legislation for apparent color (1.1%), turbidity (0.4%), fluoride content (14.2%), total coliforms (4.4%) and Escherichia coli (E. coli) (0.4%). In a brief comparison with other studies in the southeastern region of Brazil, the highest percentage of unsatisfactory samples is due to the fact that fluorine is below the minimum of &lt;0.6 ppm, demonstrating the need for training in the fluoridation process. The need to invest in the training of health surveillance teams to carry out field analyses (chlorine and pH) was also observed. This study can inform future actions, guiding the adoption of preventive and corrective measures and demonstrating the importance of monitoring water-supply quality.
DOI: 10.6084/m9.figshare.20847249
title: Pharmaceutical co-crystals of posaconazole for improvement of physicochemical properties

description: Abstract Posaconazole exerts an extended spectrum of antifungal activity against various strains of clinically relevant moulds and yeasts. In recent years, antifungal triazole posaconazole has become increasingly important for the prophylaxis and treatment of systemic mycoses. After oral administration of posaconazole, absolute bioavailability has been estimated to range from 8% to 47%. Pharmaceutical co-crystallization is a promising approach for improving dissolution rate or manipulating other physical properties of API. The objective of this study is to improve the dissolution rate of posaconazole by co-crystallization. A 1:1 stoichiometric co-crystals of adipic acid were prepared by solvent assisted grinding method. The prepared co-crystals were subjected to solid-state characterization by FTIR, PXRD and DSC studies. The physicochemical properties of posaconazole and co-crystals were assessed in terms of melting point, flowability and dissolution rate. The results indicated improvement in flow property and dissolution rate. In vitro dissolution profile of co-crystals showed a significant increased dissolution of posaconazole from initial period in 0.1 N hydrochloric acid solution. The dissolution efficiency for posaconazole-adipic acid co-crystal was 61.65 % against posaconazole, 46.58 %. Thus, co-crystallization can be a promising approach to prepare posaconazole-adipic acid co-crystals with improved physicochemical properties.
DOI: 10.6084/m9.figshare.20847249.v1
title: Pharmaceutical co-crystals of posaconazole for improvement of physicochemical properties

description: Abstract Posaconazole exerts an extended spectrum of antifungal activity against various strains of clinically relevant moulds and yeasts. In recent years, antifungal triazole posaconazole has become increasingly important for the prophylaxis and treatment of systemic mycoses. After oral administration of posaconazole, absolute bioavailability has been estimated to range from 8% to 47%. Pharmaceutical co-crystallization is a promising approach for improving dissolution rate or manipulating other physical properties of API. The objective of this study is to improve the dissolution rate of posaconazole by co-crystallization. A 1:1 stoichiometric co-crystals of adipic acid were prepared by solvent assisted grinding method. The prepared co-crystals were subjected to solid-state characterization by FTIR, PXRD and DSC studies. The physicochemical properties of posaconazole and co-crystals were assessed in terms of melting point, flowability and dissolution rate. The results indicated improvement in flow property and dissolution rate. In vitro dissolution profile of co-crystals showed a significant increased dissolution of posaconazole from initial period in 0.1 N hydrochloric acid solution. The dissolution efficiency for posaconazole-adipic acid co-crystal was 61.65 % against posaconazole, 46.58 %. Thus, co-crystallization can be a promising approach to prepare posaconazole-adipic acid co-crystals with improved physicochemical properties.
DOI: 10.6084/m9.figshare.20847276
title: Determination of perindopril erbumine by oxidative coupling reaction using 2, 6-dichloroquinone-4-chlorimide

description: Abstract Perindopril erbumine (Perindopril tert-butylamine salt) is a potent angiotensin-converting enzyme (ACE) inhibitor. It is used to treat the patients with hypertension and heart failure problems. A sensitive, inexpensive and precise analytical technique has been developed for the estimation of perindopril in bulk and formulations. The procedure involves the development of colour by forming an oxidative coupling reaction between drug (PPE) and reagent such as 2, 6-dichloroquinone-4-chlorimide (DCQC). The formed colored species were measured at (max=520 nm. The developed method showed linearity within the concentration limits of 25-75 μg mL-1. The linear correlation coefficient (r) and molar absorptivity were found to be 0.9999 and 3.285 x 103 mol-1cm-1. % Recovery ± SD values were in the range of 99.69 - 100.51 (+ 0.42 - ( 0.41) (n=3) which indicates the accuracy of the developed method. The interference of other excipients that are commonly present in formulations is found to be negligible. Precision and accuracy of the proposed method were confirmed by student t-test and F-tests at 95% confidence limits with (n-1) degrees of freedom. The validity parameters of proposed method were calculated by ICH guidelines.
DOI: 10.6084/m9.figshare.20847276.v1
title: Determination of perindopril erbumine by oxidative coupling reaction using 2, 6-dichloroquinone-4-chlorimide

description: Abstract Perindopril erbumine (Perindopril tert-butylamine salt) is a potent angiotensin-converting enzyme (ACE) inhibitor. It is used to treat the patients with hypertension and heart failure problems. A sensitive, inexpensive and precise analytical technique has been developed for the estimation of perindopril in bulk and formulations. The procedure involves the development of colour by forming an oxidative coupling reaction between drug (PPE) and reagent such as 2, 6-dichloroquinone-4-chlorimide (DCQC). The formed colored species were measured at (max=520 nm. The developed method showed linearity within the concentration limits of 25-75 μg mL-1. The linear correlation coefficient (r) and molar absorptivity were found to be 0.9999 and 3.285 x 103 mol-1cm-1. % Recovery ± SD values were in the range of 99.69 - 100.51 (+ 0.42 - ( 0.41) (n=3) which indicates the accuracy of the developed method. The interference of other excipients that are commonly present in formulations is found to be negligible. Precision and accuracy of the proposed method were confirmed by student t-test and F-tests at 95% confidence limits with (n-1) degrees of freedom. The validity parameters of proposed method were calculated by ICH guidelines.
DOI: 10.6084/m9.figshare.20847303
title: Working for Gender Equality in the Neoliberal Academia: Between Theory and Practice

description: ABSTRACT In this executive letter, Barbara Poggio reports her experience as vice-rector of equality and diversity at the University of Trento (Italy), emphasizing the issue of gender asymmetries and the current challenges in the academic environment. The text results from a lecture at the Faculty of Business at the University of Lakehead (Canada) in June 2021. The letter’s purpose is to draw attention to the implication that the predominantly male academic environment has important implications for working conditions and quality of life. In addition, it highlights the impact of the current academic transformation and the affirmation of the neoliberal agenda, emphasizing performativity, excellence, and competition, and the implication in terms of increasing precariousness.
DOI: 10.6084/m9.figshare.20847303.v1
title: Working for Gender Equality in the Neoliberal Academia: Between Theory and Practice

description: ABSTRACT In this executive letter, Barbara Poggio reports her experience as vice-rector of equality and diversity at the University of Trento (Italy), emphasizing the issue of gender asymmetries and the current challenges in the academic environment. The text results from a lecture at the Faculty of Business at the University of Lakehead (Canada) in June 2021. The letter’s purpose is to draw attention to the implication that the predominantly male academic environment has important implications for working conditions and quality of life. In addition, it highlights the impact of the current academic transformation and the affirmation of the neoliberal agenda, emphasizing performativity, excellence, and competition, and the implication in terms of increasing precariousness.
DOI: 10.6084/m9.figshare.20729588
title: Forest Seedlings Supply for Restoration of the Atlantic Forest in Rio de Janeiro, Brazil

description: Abstract Half of the territory in Rio de Janeiro (RJ) state is composed of degraded areas. This work evaluated the profile, distribution, and production capacity of plant nurseries in RJ which produce forest seedlings, as well as their species’ richness. The potential to meet the increased demand arising from environmental commitments in different hydrographic regions was also analyzed. We identified 81 active forest seedling nurseries and 73 of them participated in our interview, by adopting a regional survey. Nearly one-third of the nurseries closed down in this region in the last decade. A high richness of species in the nurseries (977 species, 99 native species/nursery) was found, representing 22% of the regional flora. Most of this species’ richness is exclusively produced by small nurseries. The current production of the nurseries is capable of supplying less than 1% of the potential demand for seedlings for restoring priority watershed areas in the state.
DOI: 10.6084/m9.figshare.20729588.v1
title: Forest Seedlings Supply for Restoration of the Atlantic Forest in Rio de Janeiro, Brazil

description: Abstract Half of the territory in Rio de Janeiro (RJ) state is composed of degraded areas. This work evaluated the profile, distribution, and production capacity of plant nurseries in RJ which produce forest seedlings, as well as their species’ richness. The potential to meet the increased demand arising from environmental commitments in different hydrographic regions was also analyzed. We identified 81 active forest seedling nurseries and 73 of them participated in our interview, by adopting a regional survey. Nearly one-third of the nurseries closed down in this region in the last decade. A high richness of species in the nurseries (977 species, 99 native species/nursery) was found, representing 22% of the regional flora. Most of this species’ richness is exclusively produced by small nurseries. The current production of the nurseries is capable of supplying less than 1% of the potential demand for seedlings for restoring priority watershed areas in the state.
DOI: 10.6084/m9.figshare.20847330
title: Access barriers to Primary Health Care in remote rural municipalities of Western Pará state, Brazil

description: Abstract This article analyzes the access to Primary Health Care in remote rural municipalities in Western Pará state, Brazil, discussing barriers and challenges before the specificities of Amazonian territories. This was a qualitative study in five municipalities with distinct spatial logics, based on rivers or roads. There were 58 interviews with managers, health professionals, and users, as well as visits to basic health units, in 2019. The analysis matrix contemplated: geographical accessibility, organizational accessibility, primary health care unit as first contact, and Primary Health Care in the health care network. It was identified that the geographical access barriers involve great distances, times, costs, poor road conditions, and transportation, with differentiated seasonal variation, according to fluvial or terrestrial flows. Organizational accessibility is hindered by the insufficient offer of consultations, exams, medications, restrictions on the days of operation, and itinerant actions, accentuated by the high professional turnover. The basic health units are the first contact service, but the demand is conditioned to the perceived resoluteness and satisfaction, where the performance of the community health agent stands out. The support for specialized care is precarious, with difficulties in supply, regulation, transportation, and communication. The Amazon socio-environmental scenario requires unique strategies for the supply and organization of services, reflected in specific funding.
DOI: 10.6084/m9.figshare.20847330.v1
title: Access barriers to Primary Health Care in remote rural municipalities of Western Pará state, Brazil

description: Abstract This article analyzes the access to Primary Health Care in remote rural municipalities in Western Pará state, Brazil, discussing barriers and challenges before the specificities of Amazonian territories. This was a qualitative study in five municipalities with distinct spatial logics, based on rivers or roads. There were 58 interviews with managers, health professionals, and users, as well as visits to basic health units, in 2019. The analysis matrix contemplated: geographical accessibility, organizational accessibility, primary health care unit as first contact, and Primary Health Care in the health care network. It was identified that the geographical access barriers involve great distances, times, costs, poor road conditions, and transportation, with differentiated seasonal variation, according to fluvial or terrestrial flows. Organizational accessibility is hindered by the insufficient offer of consultations, exams, medications, restrictions on the days of operation, and itinerant actions, accentuated by the high professional turnover. The basic health units are the first contact service, but the demand is conditioned to the perceived resoluteness and satisfaction, where the performance of the community health agent stands out. The support for specialized care is precarious, with difficulties in supply, regulation, transportation, and communication. The Amazon socio-environmental scenario requires unique strategies for the supply and organization of services, reflected in specific funding.