cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.30862715.v1
title: Chai-shen powder treated perimenopausal syndrome through the PI3K–Akt/cAMP signaling pathway: integrated clinical analysis, network pharmacology, microRNA and animal experiment

description: This study aimed to explore the pharmacological mechanism of Chai-shen powder (CSP) in the treatment of perimenopausal syndrome (PMS) and to evaluate its clinical efficacy via clinical data mining, network pharmacology, bioinformatics and experimental verification. A single-group before–after control study analyzed CSP efficacy in 100 PMS cases using data mining. PMS datasets were retrieved from the GEO database to screen for differentially expressed microRNAs (miRNAs). Their mRNA targets were predicted using miRDB and miRWalk. These targets were considered therapeutic targets for PMS. CSP targets were screened from databases. The active components and key targets were identified by network pharmacology. The most important targets were confirmed by molecular docking. The prediction results of network pharmacology were verified by experiment. Data mining showed that the effective rate of CSP was 87.33%. Through bioinformatics and network pharmacology, 10 targets and nine chemical components were screened. CSP regulates hormone levels and inhibits ovarian injury of PMS through PI3K–Akt and cAMP signaling pathways and three key targets (SRC, PIK3CA and PRKACA). The clinical effective rate of CSP in this study was 87.33%. CSP may alleviate PMS by regulating hormone levels, mitigating ovarian injury and acting through multi-pathway, multi-target mechanisms. This study investigated how Chai-shen powder (CSP), a traditional Chinese herbal formula, helps relieve menopausal symptoms such as hot flashes with sweating and emotional lability. By analyzing 100 patients’ treatment records, we found 87.33% of patients experienced symptom improvement. Using data analysis and laboratory tests, we discovered that CSP works by balancing hormone levels, protecting ovarian function and targeting multiple biological processes simultaneously. These findings bridge traditional medicine with modern scientific understanding for better menopausal care.
DOI: 10.48597/8pzz-ggrj
title: Inorganics in air and particle phase and PAHs (polycyclic aromatic hydrocarbons, 16) at Rucava

description: Measurement of Inorganics in air and particle phase and PAHs (polycyclic aromatic hydrocarbons, 16) at Rucava
DOI: 10.48597/936u-845d
title: Arsenic at Rucava

description: Measurement of Arsenic at Rucava
DOI: 10.48597/nhf7-xz5w
title: Heavy metals at Rucava

description: Measurement of Heavy metals at Rucava
DOI: 10.48597/xhu6-5kw7
title: Pm25_mass at Rucava

description: Measurement of Pm25_mass at Rucava
DOI: 10.48597/xjt9-thcg
title: Pm10_mass at Rucava

description: Measurement of Pm10_mass at Rucava
DOI: 10.48597/3phb-d3xq
title: Measurement of Nickel at Rucava

description: Measurement of Nickel at Rucava
DOI: 10.48597/7juw-qn8v
title: Measurement of Inden_123cd_pyrene at Rucava

description: Measurement of Inden_123cd_pyrene at Rucava
DOI: 10.48597/8pyb-fcs4
title: Measurement of Dibenzo_ah_anthracene at Rucava

description: Measurement of Dibenzo_ah_anthracene at Rucava
DOI: 10.5281/zenodo.17902492
title: Nyx initial particle data from CosmicIC

description: This record contains a tar file with initial particle data for LyA simulations in Nyx with box size 20 Mpc/h with 512^3 particles. It only contains the dark matter particle locations and velocities. No baryonic matter data. This was generated using the CosmicIC codebase, which has 1 LPT implementation.
DOI: 10.5281/zenodo.17902493
title: Nyx initial particle data from CosmicIC

description: This record contains a tar file with initial particle data for LyA simulations in Nyx with box size 20 Mpc/h with 512^3 particles. It only contains the dark matter particle locations and velocities. No baryonic matter data. This was generated using the CosmicIC codebase, which has 1 LPT implementation.
DOI: 10.48597/kyzc-5j42
title: Measurement of Lead at Rucava

description: Measurement of Lead at Rucava
DOI: 10.48597/q4fh-dteu
title: Measurement of Benz_a_anthracene at Rucava

description: Measurement of Benz_a_anthracene at Rucava
DOI: 10.48597/sjfa-pwmc
title: Measurement of Arsenic at Rucava

description: Measurement of Arsenic at Rucava
DOI: 10.48597/w4uc-pa6e
title: Measurement of Cadmium at Rucava

description: Measurement of Cadmium at Rucava
DOI: 10.48597/ybge-m9re
title: Measurement of Benzo_b_fluoranthene at Rucava

description: Measurement of Benzo_b_fluoranthene at Rucava
DOI: 10.48597/z66h-bjd6
title: Measurement of Benzo_a_pyrene at Rucava

description: Measurement of Benzo_a_pyrene at Rucava
DOI: 10.48597/zets-j2zn
title: Measurement of Benzo_k_fluoranthene at Rucava

description: Measurement of Benzo_k_fluoranthene at Rucava
DOI: 10.48597/gb57-z5ch
title: Heavy metals, inorganics in air and particle phase and PAHs (polycyclic aromatic hydrocarbons, 16) at Rucava

description: Measurement of Heavy metals, inorganics in air and particle phase and PAHs (polycyclic aromatic hydrocarbons, 16) at Rucava
DOI: 10.48597/x58g-wgmk
title: Benzo_b_fluoranthene at Rucava

description: Measurement of Benzo_b_fluoranthene at Rucava
DOI: 10.48597/2dba-bvwu
title: Arsenic at Rucava

description: Measurement of Arsenic at Rucava
DOI: 10.48597/55dh-zhdz
title: Lead at Rucava

description: Measurement of Lead at Rucava
DOI: 10.48597/5f7r-p2y9
title: Benzo_b_fluoranthene at Rucava

description: Measurement of Benzo_b_fluoranthene at Rucava
DOI: 10.48597/h4vw-fv8a
title: Benz_a_anthracene at Rucava

description: Measurement of Benz_a_anthracene at Rucava
DOI: 10.48597/hh5h-mfer
title: Dibenzo_ah_anthracene at Rucava

description: Measurement of Dibenzo_ah_anthracene at Rucava
DOI: 10.48597/mwdz-q9zt
title: Inden_123cd_pyrene at Rucava

description: Measurement of Inden_123cd_pyrene at Rucava
DOI: 10.48597/nhft-xpug
title: Benzo_k_fluoranthene at Rucava

description: Measurement of Benzo_k_fluoranthene at Rucava
DOI: 10.48597/qmcw-pnyt
title: Nickel at Rucava

description: Measurement of Nickel at Rucava
DOI: 10.48597/sxcc-92mk
title: Cadmium at Rucava

description: Measurement of Cadmium at Rucava
DOI: 10.48597/2dh3-upds
title: Measurement of Benzo_b_fluoranthene at Rucava

description: Measurement of Benzo_b_fluoranthene at Rucava
DOI: 10.48597/zakp-tqz2
title: Benzo_a_pyrene at Rucava

description: Measurement of Benzo_a_pyrene at Rucava
DOI: 10.48597/5v5r-fet8
title: Measurement of Cadmium at Rucava

description: Measurement of Cadmium at Rucava
DOI: 10.48597/7qfb-fkud
title: Measurement of Arsenic at Rucava

description: Measurement of Arsenic at Rucava
DOI: 10.48597/ay75-ydat
title: Measurement of Benzo_a_pyrene at Rucava

description: Measurement of Benzo_a_pyrene at Rucava
DOI: 10.48597/fqzf-d7yg
title: Measurement of Nickel at Rucava

description: Measurement of Nickel at Rucava
DOI: 10.48597/p9tm-rx5d
title: Measurement of Benzo_k_fluoranthene at Rucava

description: Measurement of Benzo_k_fluoranthene at Rucava
DOI: 10.6084/m9.figshare.30823997.v2
title: Data availability_GPR39_MK

description: G protein-coupled receptor 39 (GPR39) is an orphan receptor that is highly expressed in renal collecting duct principal cells. GPR39 activation <i>in vivo</i> leads to reduced urinary concentration capacity. In this study, we utilized mpkCCD cells, a model of principal cells in the collecting duct, to examine the cell biological effects of GPR39 activation. Pharmacological activation of GPR39 with the synthetic agonist cpd1324 impaired vasopressin-mediated aquaporin-2 (AQP2) apical trafficking and reduced total AQP2 expression following long-term treatment, consistent with its known <i>in vivo</i> role. These effects were absent in GPR39 knockout cells. In addition, GPR39 activation altered apical membrane morphology, disrupted the tight junction network, and reduced cortical F-actin expression, suggesting a shift toward a dedifferentiated phenotype. GPR39 activation also increased glycolytic ATP production while reducing mitochondrial ATP output without affecting proliferation. RNA-seq analysis of acutely treated mpkCCD cells revealed upregulation of inflammatory and dedifferentiation-associated gene programs, including cytokines. These findings indicate that the role of GPR39 in principal cells goes beyond AQP2 regulation and imply that GPR39 functions as a negative regulator of epithelial differentiation, perhaps acting to coordinate metabolic and inflammatory responses to stress.
DOI: 10.48597/r6sj-9mzc
title: Measurement of Lead at Rucava

description: Measurement of Lead at Rucava
DOI: 10.48597/suyv-zp6p
title: Measurement of Dibenzo_ah_anthracene at Rucava

description: Measurement of Dibenzo_ah_anthracene at Rucava
DOI: 10.48597/z5qv-vzjr
title: Measurement of Benz_a_anthracene at Rucava

description: Measurement of Benz_a_anthracene at Rucava
DOI: 10.48597/2bga-mv5b
title: Dibenzo_ah_anthracene at Rucava

description: Measurement of Dibenzo_ah_anthracene at Rucava
DOI: 10.48597/2mer-mtw3
title: Benzo_k_fluoranthene at Rucava

description: Measurement of Benzo_k_fluoranthene at Rucava
DOI: 10.48597/9avj-ktu4
title: Benzo_b_fluoranthene at Rucava

description: Measurement of Benzo_b_fluoranthene at Rucava
DOI: 10.48597/awe4-2n8h
title: Benz_a_anthracene at Rucava

description: Measurement of Benz_a_anthracene at Rucava
DOI: 10.48597/p5vj-u4u6
title: Cadmium at Rucava

description: Measurement of Cadmium at Rucava
DOI: 10.48597/tyka-fkba
title: Nickel at Rucava

description: Measurement of Nickel at Rucava
DOI: 10.48597/wc7f-ycy5
title: Lead at Rucava

description: Measurement of Lead at Rucava
DOI: 10.48597/wfr7-xpch
title: Benzo_a_pyrene at Rucava

description: Measurement of Benzo_a_pyrene at Rucava
DOI: 10.48597/uvc4-zb9x
title: Nitrogen_dioxide at Sniezka

description: Measurement of Nitrogen_dioxide at Sniezka
DOI: 10.48597/zadu-bjcq
title: Arsenic at Rucava

description: Measurement of Arsenic at Rucava
DOI: 10.48597/auet-dbcy
title: Dibenzo_ah_anthracene at Rucava

description: Measurement of Dibenzo_ah_anthracene at Rucava
DOI: 10.48597/322m-audu
title: Inden_123cd_pyrene at Rucava

description: Measurement of Inden_123cd_pyrene at Rucava
DOI: 10.48597/ygpv-rdck
title: Nitrogen_dioxide at Sniezka

description: Measurement of Nitrogen_dioxide at Sniezka
DOI: 10.48597/67nm-9ydd
title: PM mass at Rucava

description: Measurement of PM mass at Rucava
DOI: 10.48597/n8gk-a5ph
title: Inorganics in precipitation at Preila

description: Measurement of Inorganics in precipitation at Preila
DOI: 10.48597/puqc-4xm4
title: Inorganics in precipitation at Rucava

description: Measurement of Inorganics in precipitation at Rucava
DOI: 10.48597/d5gp-vede
title: Sulphate_corrected at Preila

description: Measurement of Sulphate_corrected at Preila
DOI: 10.48597/ufjm-8ewk
title: Heavy metals at Rucava

description: Measurement of Heavy metals at Rucava
DOI: 10.48597/h96g-2s95
title: PM mass at Rucava

description: Measurement of PM mass at Rucava
DOI: 10.48597/yrys-wrbj
title: Sulphate_corrected at Rucava

description: Measurement of Sulphate_corrected at Rucava
DOI: 10.48597/2u42-45d8
title: Inorganics in air and particle phase at Vredepeel

description: Measurement of Inorganics in air and particle phase at Vredepeel
DOI: 10.48597/pd8z-6cvs
title: Sulphate_corrected at De Zilk

description: Measurement of Sulphate_corrected at De Zilk
DOI: 10.48597/uk7v-qm8s
title: Sulphate_corrected at Vredepeel

description: Measurement of Sulphate_corrected at Vredepeel
DOI: 10.48597/c6sv-4pjh
title: Heavy metals at Rucava

description: Measurement of Heavy metals at Rucava
DOI: 10.48597/xjnv-2h56
title: Sulphate_corrected at Rucava

description: Measurement of Sulphate_corrected at Rucava
DOI: 10.48597/bk6g-qhwf
title: Nitrogen oxides at Cabauw Wielsekade

description: Measurement of Nitrogen oxides at Cabauw Wielsekade
DOI: 10.48597/vcba-6t3d
title: Nitrogen oxides at De Zilk

description: Measurement of Nitrogen oxides at De Zilk
DOI: 10.48597/fp2a-xpzy
title: Pm10_mass at De Zilk

description: Measurement of Pm10_mass at De Zilk
DOI: 10.48597/jgu6-89jg
title: Pm10_mass at Vredepeel

description: Measurement of Pm10_mass at Vredepeel
DOI: 10.48597/nmbc-jhn8
title: Pm10_mass at Eibergen

description: Measurement of Pm10_mass at Eibergen
DOI: 10.48597/qn9y-d9td
title: Nitrogen oxides at Eibergen

description: Measurement of Nitrogen oxides at Eibergen
DOI: 10.48597/rz2f-kk9b
title: Pm10_mass at Kollumerwaard

description: Measurement of Pm10_mass at Kollumerwaard
DOI: 10.48597/xmay-7drp
title: Pm10_mass at Cabauw Wielsekade

description: Measurement of Pm10_mass at Cabauw Wielsekade
DOI: 10.48597/4q4c-adr7
title: PM mass at Rucava

description: Measurement of PM mass at Rucava
DOI: 10.48597/xx5b-gdnr
title: Nitrogen oxides at Vredepeel

description: Measurement of Nitrogen oxides at Vredepeel
DOI: 10.48597/af37-7ew9
title: Inorganics in precipitation at Preila

description: Measurement of Inorganics in precipitation at Preila
DOI: 10.48597/3q33-3fq7
title: Sulphate_corrected at De Zilk

description: Measurement of Sulphate_corrected at De Zilk
DOI: 10.48597/zdaj-pmgq
title: Inorganics in precipitation at De Zilk

description: Measurement of Inorganics in precipitation at De Zilk
DOI: 10.48597/9y6d-uzec
title: Measurement of Inden_123cd_pyrene at Rucava

description: Measurement of Inden_123cd_pyrene at Rucava
DOI: 10.48597/b4ee-v3pn
title: Measurement of PM mass at Rucava

description: Measurement of PM mass at Rucava
DOI: 10.48597/p7rm-4u68
title: PAHs (polycyclic aromatic hydrocarbons, 16) at Rucava

description: Measurement of PAHs (polycyclic aromatic hydrocarbons, 16) at Rucava
DOI: 10.48597/mgry-cd94
title: Inorganics in precipitation at De Zilk

description: Measurement of Inorganics in precipitation at De Zilk
DOI: 10.48597/snv7-5faj
title: Measurement of Heavy metals, inorganics in air and particle phase and PAHs (polycyclic aromatic hydrocarbons, 16) at Rucava

description: Measurement of Heavy metals, inorganics in air and particle phase and PAHs (polycyclic aromatic hydrocarbons, 16) at Rucava
DOI: 10.48597/ay5n-3a2u
title: Measurement of Dibenzo_ah_anthracene at Rucava

description: Measurement of Dibenzo_ah_anthracene at Rucava
DOI: 10.48597/ub93-7naa
title: Measurement of Benzo_b_fluoranthene at Rucava

description: Measurement of Benzo_b_fluoranthene at Rucava
DOI: 10.48597/6cz3-xqgk
title: Inorganics in air and particle phase at De Zilk

description: Measurement of Inorganics in air and particle phase at De Zilk
DOI: 10.48597/8pmg-jzn5
title: Heavy metals at De Zilk

description: Measurement of Heavy metals at De Zilk
DOI: 10.48597/b7gc-ua5w
title: Heavy metals and inorganics in air and particle phase at Bilthoven

description: Measurement of Heavy metals and inorganics in air and particle phase at Bilthoven
DOI: 10.48597/mn82-nksn
title: Ammonia at De Zilk

description: Measurement of Ammonia at De Zilk
DOI: 10.48597/hg3n-ehp8
title: Inorganics in air and particle phase at Vredepeel

description: Measurement of Inorganics in air and particle phase at Vredepeel
DOI: 10.48597/pwvg-qu8s
title: Heavy metals and inorganics in air and particle phase at Cabauw Wielsekade

description: Measurement of Heavy metals and inorganics in air and particle phase at Cabauw Wielsekade
DOI: 10.48597/494p-sg2v
title: Pm25_mass at De Zilk

description: Measurement of Pm25_mass at De Zilk
DOI: 10.48597/9yv5-kqwn
title: Pm25_mass at Vredepeel

description: Measurement of Pm25_mass at Vredepeel
DOI: 10.48597/cchb-pnx3
title: Nitrogen oxides at Kollumerwaard

description: Measurement of Nitrogen oxides at Kollumerwaard
DOI: 10.48597/k84t-hwqb
title: Pm25_mass at Cabauw Wielsekade

description: Measurement of Pm25_mass at Cabauw Wielsekade
DOI: 10.48597/rgcf-bx5s
title: Pm25_mass at Kollumerwaard

description: Measurement of Pm25_mass at Kollumerwaard
DOI: 10.48597/8ryf-paus
title: Inorganics in precipitation at De Zilk

description: Measurement of Inorganics in precipitation at De Zilk
DOI: 10.48597/98un-xw87
title: Heavy metals at Vredepeel

description: Measurement of Heavy metals at Vredepeel
DOI: 10.48597/cwqt-vqf9
title: Heavy metals at Rucava

description: Measurement of Heavy metals at Rucava
DOI: 10.48597/kdtr-d77j
title: Inorganics in air and particle phase at Rucava

description: Measurement of Inorganics in air and particle phase at Rucava
DOI: 10.48597/n457-gzyq
title: PAHs (polycyclic aromatic hydrocarbons, 16) at De Zilk

description: Measurement of PAHs (polycyclic aromatic hydrocarbons, 16) at De Zilk
DOI: 10.48597/xghp-ru6y
title: PAHs (polycyclic aromatic hydrocarbons, 16) at Rucava

description: Measurement of PAHs (polycyclic aromatic hydrocarbons, 16) at Rucava
DOI: 10.48597/zamj-2r66
title: Mercury at De Zilk

description: Measurement of Mercury at De Zilk
DOI: 10.48597/2hhw-4xya
title: Measurement of Inorganics in precipitation at Rucava

description: Measurement of Inorganics in precipitation at Rucava
DOI: 10.48597/mv6j-f6p9
title: Measurement of PM mass at Rucava

description: Measurement of PM mass at Rucava
DOI: 10.48597/yn8s-2scs
title: Measurement of Sulphate_corrected at Rucava

description: Measurement of Sulphate_corrected at Rucava
DOI: 10.48597/qjy5-897h
title: Measurement of Heavy metals at Rucava

description: Measurement of Heavy metals at Rucava
DOI: 10.48597/r85m-khw2
title: Measurement of Pm10_mass at Rucava

description: Measurement of Pm10_mass at Rucava
DOI: 10.6084/m9.figshare.28646395
title: Optimizing energy and carbon emissions in Egyptian residential buildings using simulation‐based EDGE standards

description: Sustainable design focuses on enhancing environmental quality and improving indoor conditions while minimizing negative impacts. This study optimizes energy consumption and carbon emissions by examining the influence of building orientation and thermal insulation in Egyptian residential buildings. The objective is to identify the optimal thermal insulation thickness for building envelopes based on Excellence in Design for Greater Efficiencies (EDGE) standards. Simulations were performed in 11 cities (Aswan, Cairo, Alexandria, Hurgada, Sharm El Sheikh, Luxor, Port Said, El Dakhla, El Quesir, Ismailia, and Suez) spanning six climate zones with various facade orientations and climatic conditions. The results demonstrate that applying extruded polystyrene (XPS) insulation reduces cooling energy consumption by 11% to 67%, influenced by climate conditions, local habits, and building orientation. Additionally, carbon emissions decrease by 3.9% to 11.26%, while annual cost savings per building range from 1,319 to 3,710 EGP, emphasizing the economic and practical benefits of sustainable practices. These findings provide essential guidelines for reducing energy demand and improving thermal efficiency in Egyptian residential buildings. The study’s insights contribute to urban planning strategies, national energy policies, global sustainability goals, and raising awareness of energy-efficient solutions, supporting energy-efficient design and fostering sustainable urban development across diverse regions and climatic environments effectively.
DOI: 10.6084/m9.figshare.28646395.v1
title: Optimizing energy and carbon emissions in Egyptian residential buildings using simulation‐based EDGE standards

description: Sustainable design focuses on enhancing environmental quality and improving indoor conditions while minimizing negative impacts. This study optimizes energy consumption and carbon emissions by examining the influence of building orientation and thermal insulation in Egyptian residential buildings. The objective is to identify the optimal thermal insulation thickness for building envelopes based on Excellence in Design for Greater Efficiencies (EDGE) standards. Simulations were performed in 11 cities (Aswan, Cairo, Alexandria, Hurgada, Sharm El Sheikh, Luxor, Port Said, El Dakhla, El Quesir, Ismailia, and Suez) spanning six climate zones with various facade orientations and climatic conditions. The results demonstrate that applying extruded polystyrene (XPS) insulation reduces cooling energy consumption by 11% to 67%, influenced by climate conditions, local habits, and building orientation. Additionally, carbon emissions decrease by 3.9% to 11.26%, while annual cost savings per building range from 1,319 to 3,710 EGP, emphasizing the economic and practical benefits of sustainable practices. These findings provide essential guidelines for reducing energy demand and improving thermal efficiency in Egyptian residential buildings. The study’s insights contribute to urban planning strategies, national energy policies, global sustainability goals, and raising awareness of energy-efficient solutions, supporting energy-efficient design and fostering sustainable urban development across diverse regions and climatic environments effectively.
DOI: 10.48597/w93w-tsx5
title: Measurement of Sulphate_corrected at Vredepeel

description: Measurement of Sulphate_corrected at Vredepeel
DOI: 10.48597/22wh-uhez
title: Measurement of Sulphate_corrected at Rucava

description: Measurement of Sulphate_corrected at Rucava
DOI: 10.48597/wawt-u4gb
title: Measurement of Sulphate_corrected at De Zilk

description: Measurement of Sulphate_corrected at De Zilk
DOI: 10.48597/s8a7-pk2d
title: Measurement of PM mass at Rucava

description: Measurement of PM mass at Rucava
DOI: 10.48597/rfw8-b4c9
title: Measurement of Nitrogen_dioxide at Sniezka

description: Measurement of Nitrogen_dioxide at Sniezka
DOI: 10.48597/u7xx-txq4
title: Measurement of Nitrogen_dioxide at Sniezka

description: Measurement of Nitrogen_dioxide at Sniezka
DOI: 10.48597/kgnz-au58
title: Measurement of Nitrogen_dioxide at Sniezka

description: Measurement of Nitrogen_dioxide at Sniezka
DOI: 10.48597/mmwz-m3f8
title: Measurement of Nitrogen_dioxide at Sniezka

description: Measurement of Nitrogen_dioxide at Sniezka
DOI: 10.48597/yb4w-texc
title: Measurement of PM mass at Rucava

description: Measurement of PM mass at Rucava
DOI: 10.48597/9872-7bff
title: Measurement of PAHs (polycyclic aromatic hydrocarbons, 16) at Rucava

description: Measurement of PAHs (polycyclic aromatic hydrocarbons, 16) at Rucava
DOI: 10.6084/m9.figshare.30862721
title: Geospatial analysis of emergency shelter accessibility under flood-induced road disruptions: a case study of central Guangzhou, China

description: Geospatial modeling offers critical insights for assessing emergency shelter accessibility in the context of disaster-induced disruptions in flood-prone cities. This study develops a GIS-based framework that integrates hydrodynamic flood simulation and accessibility analysis to evaluate flood-induced road disruptions in central Guangzhou, China. Using the Cellular Automata Dual-DraInagE Simulation (CADDIES)-2D model, flooding scenarios with 10-, 20-, and 50-year return periods were simulated, and impassable roads were incorporated into a network-based analysis. Community-level accessibility to shelters was measured with the Gaussian Two-Step Floating Catchment Area (G2SFCA) method, which accounts for shelter capacity, distance decay, and disrupted travel paths. Results show a progressive decline in accessibility as flood severity increases: 46.77%, 47.44%, and 52.56% of communities experienced reduced access under the three scenarios. The number of high-risk communities, those exposed to both severe flooding and high vulnerability (measured by accessibility and socioeconomic conditions), rose from 6 (10-year) to 34 (20-year) and 98 (50-year). These communities are mainly concentrated in peripheral districts with sparse shelter coverage. These findings underscore the need for spatially optimized shelter allocation, resilient evacuation routes, and consideration of social vulnerability in emergency planning. The proposed framework offers transferable insights for urban resilience strategies, supporting equitable disaster preparedness in other flood-prone megacities.