cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.20484548.v1
title: It is time anti-CGRP monoclonal antibodies be considered first-line prophylaxis for migraine

description: ABSTRACT The result of more than thirty years of research, anti-CGRP monoclonal antibodies are currently the state of the art for migraine preventive therapy. Their efficacy and safety, supported by an already large and growing body of evidence, are added by many other advantages: an early onset of action, favorable posology, negligible pharmacological interaction, and a broad-reaching efficacy in many challenging clinical contexts. When compared to standard prophylactics, these novel medications seem at least as efficacious, clearly more tolerable and, consequently, with a superior adherence profile. Furthermore, recently published analyses indicate that they are cost-effective, especially among those with chronic migraine. Yet, current guidelines endorse their use only after multiple other preventives have failed or have been deemed not tolerable. Although this recommendation may have been sensible at first, the now available data strongly point that time has come for anti-CGRP monoclonal antibodies to be acknowledged as first-line treatments for migraine patients with severe disability. For these individuals, delaying treatment until several other alternatives have failed incurs in significant losses, both economically and to many relevant aspects of their lives.
DOI: 10.6084/m9.figshare.20484548
title: It is time anti-CGRP monoclonal antibodies be considered first-line prophylaxis for migraine

description: ABSTRACT The result of more than thirty years of research, anti-CGRP monoclonal antibodies are currently the state of the art for migraine preventive therapy. Their efficacy and safety, supported by an already large and growing body of evidence, are added by many other advantages: an early onset of action, favorable posology, negligible pharmacological interaction, and a broad-reaching efficacy in many challenging clinical contexts. When compared to standard prophylactics, these novel medications seem at least as efficacious, clearly more tolerable and, consequently, with a superior adherence profile. Furthermore, recently published analyses indicate that they are cost-effective, especially among those with chronic migraine. Yet, current guidelines endorse their use only after multiple other preventives have failed or have been deemed not tolerable. Although this recommendation may have been sensible at first, the now available data strongly point that time has come for anti-CGRP monoclonal antibodies to be acknowledged as first-line treatments for migraine patients with severe disability. For these individuals, delaying treatment until several other alternatives have failed incurs in significant losses, both economically and to many relevant aspects of their lives.
DOI: 10.6084/m9.figshare.20484552
title: Native legumes and spineless cactus in supplementation of goats grazing in Caatinga rangeland: intake, performance, carcass characteristics, and meat quality

description: ABSTRACT. The study evaluated the performance, carcass characteristics, tissue composition, and meat quality of goats raised on pasture in the Caatinga rangeland supplemented with Leucena (Leucaena leucocephala) and Sabiá (Mimosa caesapiniifolia) hays associated or not with spineless cactus (Nopalea cochenillifera), and without supplementation. Thirty male castrated goats, no defined breed, with an average body weight of 15.5 kg ± 0.64 were used, distributed in a randomized block design, according to the initial weight of the animals. The experimental period lasted 105 days. The highest intake of DM, OM and CP occurred in the animals supplemented with Leucena hay associated or not with spineless cactus. The intake of NDF was higher (p &lt;0.05) for animals fed only with Leucena and Sabiá hays. The highest intake of TDN was observed for diets, only grazing, and hays associated with spineless cactus. The daily weight gain for goats fed with Leucena hay and spineless cactus was 68.5% higher (p &lt;0.05) than on grazing alone. Consequently, they obtained the highest (p &lt;0.05) weights and yields of carcasses, shoulder, loin, and leg cuts, conformation and finishing scores, leg muscle index, and % fat in the leg of goats. The meat quality did not differ. The supplementation with Leucena hay associated with spineless cactus improves performance, weights, and yields of the carcass, commercial cuts, leg muscle of goats grazing in the Caatinga rangeland.
DOI: 10.6084/m9.figshare.20484552.v1
title: Native legumes and spineless cactus in supplementation of goats grazing in Caatinga rangeland: intake, performance, carcass characteristics, and meat quality

description: ABSTRACT. The study evaluated the performance, carcass characteristics, tissue composition, and meat quality of goats raised on pasture in the Caatinga rangeland supplemented with Leucena (Leucaena leucocephala) and Sabiá (Mimosa caesapiniifolia) hays associated or not with spineless cactus (Nopalea cochenillifera), and without supplementation. Thirty male castrated goats, no defined breed, with an average body weight of 15.5 kg ± 0.64 were used, distributed in a randomized block design, according to the initial weight of the animals. The experimental period lasted 105 days. The highest intake of DM, OM and CP occurred in the animals supplemented with Leucena hay associated or not with spineless cactus. The intake of NDF was higher (p &lt;0.05) for animals fed only with Leucena and Sabiá hays. The highest intake of TDN was observed for diets, only grazing, and hays associated with spineless cactus. The daily weight gain for goats fed with Leucena hay and spineless cactus was 68.5% higher (p &lt;0.05) than on grazing alone. Consequently, they obtained the highest (p &lt;0.05) weights and yields of carcasses, shoulder, loin, and leg cuts, conformation and finishing scores, leg muscle index, and % fat in the leg of goats. The meat quality did not differ. The supplementation with Leucena hay associated with spineless cactus improves performance, weights, and yields of the carcass, commercial cuts, leg muscle of goats grazing in the Caatinga rangeland.
DOI: 10.6084/m9.figshare.20455243
title: A study on the correlation between pain frequency and severity and vitamin B12 levels in episodic and chronic migraine

description: ABSTRACT Background It is believed that vitamin B12 deficiency and hyperhomocysteinemia cause endothelial cell damage by increasing the levels of free oxygen radicals, which may, in turn, be related to the onset of migraine episodes. Objective The objective of our study was to ascertain a correlation between vitamin B12 levels and migraine attack frequency and pain severity. Methods 127 patients with migraine and 45 healthy controls who presented to Okmeydanı Training and Research Hospital were included in the study. The migraine attack frequency and the duration and severity of pain in migraineurs were recorded. Pain severity was evaluated using a visual analogue scale (VAS). Vitamin B12 levels below 300 ng/L were considered low. Results The vitamin B12 levels in migraineurs were found to be significantly lower than those in the control group (227.30 ± 104.72 ng/L vs 278.44 ± 149.83 ng/L; p = 0.047). The vitamin B12 levels of patients with chronic migraine (CM) were found to be lower than those in patients with less frequent migraine attacks (197.50 ± 69.16 ng/L vs 278.56 ± 147.91 ng/L; p = 0.019). The ratio of vitamin B12 levels of 300 ng/L and above in patients with CM was lower than that of patients with episodic migraine (p &lt; 0.05). Conclusions Along with attack frequency and pain severity assessment, it is important that migraine follow-ups should include regular measurement of vitamin B12 levels. We found lower vitamin B12 values in the CM group.
DOI: 10.6084/m9.figshare.20455243.v1
title: A study on the correlation between pain frequency and severity and vitamin B12 levels in episodic and chronic migraine

description: ABSTRACT Background It is believed that vitamin B12 deficiency and hyperhomocysteinemia cause endothelial cell damage by increasing the levels of free oxygen radicals, which may, in turn, be related to the onset of migraine episodes. Objective The objective of our study was to ascertain a correlation between vitamin B12 levels and migraine attack frequency and pain severity. Methods 127 patients with migraine and 45 healthy controls who presented to Okmeydanı Training and Research Hospital were included in the study. The migraine attack frequency and the duration and severity of pain in migraineurs were recorded. Pain severity was evaluated using a visual analogue scale (VAS). Vitamin B12 levels below 300 ng/L were considered low. Results The vitamin B12 levels in migraineurs were found to be significantly lower than those in the control group (227.30 ± 104.72 ng/L vs 278.44 ± 149.83 ng/L; p = 0.047). The vitamin B12 levels of patients with chronic migraine (CM) were found to be lower than those in patients with less frequent migraine attacks (197.50 ± 69.16 ng/L vs 278.56 ± 147.91 ng/L; p = 0.019). The ratio of vitamin B12 levels of 300 ng/L and above in patients with CM was lower than that of patients with episodic migraine (p &lt; 0.05). Conclusions Along with attack frequency and pain severity assessment, it is important that migraine follow-ups should include regular measurement of vitamin B12 levels. We found lower vitamin B12 values in the CM group.
DOI: 10.6084/m9.figshare.20484557
title: The twin deficit theory in a dynamic consistent stock-flow model for an open economy

description: ABSTRACT This paper aims to incorporate explicitly the twin deficits theory in a stock-flow consistent model to analyze the impact of fiscal policy and public debt dynamics in a post-Keynesian model, investigating the effects and limitations. Even rejecting many neoclassical hypotheses, fiscal policy has limitation to stimulate permanently economic growth because if it’s incompatible with balance of payment equilibrium, net external debt would rise and become unsustainable. Finally, this hypothesis is tested empirically and it is verified that the dynamics of the fiscal policy and external position are associated when specified according to Godley and Cripps (1983) and modified by Pérez Caldentey (2007).
DOI: 10.6084/m9.figshare.20484557.v1
title: The twin deficit theory in a dynamic consistent stock-flow model for an open economy

description: ABSTRACT This paper aims to incorporate explicitly the twin deficits theory in a stock-flow consistent model to analyze the impact of fiscal policy and public debt dynamics in a post-Keynesian model, investigating the effects and limitations. Even rejecting many neoclassical hypotheses, fiscal policy has limitation to stimulate permanently economic growth because if it’s incompatible with balance of payment equilibrium, net external debt would rise and become unsustainable. Finally, this hypothesis is tested empirically and it is verified that the dynamics of the fiscal policy and external position are associated when specified according to Godley and Cripps (1983) and modified by Pérez Caldentey (2007).
DOI: 10.6084/m9.figshare.20484560
title: Energy supplementation as strategy of pasture management

description: ABSTRACT. This study evaluated the effect of increased energy via supplementation on the performance, ingestive behavior, nutrient digestibility, and nitrogen metabolism of grazing heifers fed tropical forage in the rainy-dry transition season. Treatments consisted of mineral supplementation ad libitum (control) and multiple supplements formulated to provide different energy levels and the same amount of protein (300 g CP animal d-1) and were denominated as low (LE; 340 g TDN animal d-1), medium (ME; 780 g TDN animal d-1) and high (HE; 1220 g TDN animal d-1) energy. Animals supplemented with ME, and HE had a greater average daily gain in relation to the control treatment, with an increase of 41 and 46%, respectively. Greater values for total apparent digestibility of neutral detergent fiber were observed for the treatment HE. Lesser values of urinary urea N were observed for the control and HE treatments. Our results define the use of energy levels in the supplement as a tool for pasture management. If the purpose of the production system is to enhance forage intake, the option is to supply supplements with less energy levels. In contrast, if the purpose is to increase the stocking rate, supplements with greater energy levels should be used.
DOI: 10.6084/m9.figshare.20484560.v1
title: Energy supplementation as strategy of pasture management

description: ABSTRACT. This study evaluated the effect of increased energy via supplementation on the performance, ingestive behavior, nutrient digestibility, and nitrogen metabolism of grazing heifers fed tropical forage in the rainy-dry transition season. Treatments consisted of mineral supplementation ad libitum (control) and multiple supplements formulated to provide different energy levels and the same amount of protein (300 g CP animal d-1) and were denominated as low (LE; 340 g TDN animal d-1), medium (ME; 780 g TDN animal d-1) and high (HE; 1220 g TDN animal d-1) energy. Animals supplemented with ME, and HE had a greater average daily gain in relation to the control treatment, with an increase of 41 and 46%, respectively. Greater values for total apparent digestibility of neutral detergent fiber were observed for the treatment HE. Lesser values of urinary urea N were observed for the control and HE treatments. Our results define the use of energy levels in the supplement as a tool for pasture management. If the purpose of the production system is to enhance forage intake, the option is to supply supplements with less energy levels. In contrast, if the purpose is to increase the stocking rate, supplements with greater energy levels should be used.
DOI: 10.6084/m9.figshare.20484561
title: Globalization, deglobalization and Brazil

description: ABSTRACT The last three decades have witnessed important changes in transportation, communication and data processing, with effects over productive processes, trade flows and the international movement of capital. From the viewpoint of developing economies this led to the recommendation of adhering to this process as a tool to foster economic and social development. As for the Brazilian economy, its participation in the process of globalization has been limited so far, except for the movement of capital. Its share in total merchandise trade is low, as is the number of preferential trade agreements. It has not been possible to reduce the “economic distance” towards the high-income economies.
DOI: 10.6084/m9.figshare.20484561.v1
title: Globalization, deglobalization and Brazil

description: ABSTRACT The last three decades have witnessed important changes in transportation, communication and data processing, with effects over productive processes, trade flows and the international movement of capital. From the viewpoint of developing economies this led to the recommendation of adhering to this process as a tool to foster economic and social development. As for the Brazilian economy, its participation in the process of globalization has been limited so far, except for the movement of capital. Its share in total merchandise trade is low, as is the number of preferential trade agreements. It has not been possible to reduce the “economic distance” towards the high-income economies.
DOI: 10.6084/m9.figshare.20484570
title: A principal component analysis required in technical assistance guidance for chilled raw milk producers

description: ABSTRACT. The purpose of the present study was to evaluate the principal component analysis (PCA) to guide technical assistance regarding several dairy farms’ issues, which includes improving microbiological quality and physical-chemical composition of raw refrigerated milk. Data of monthly analysis of fat, protein, lactose, dry defatted stratum, somatic cell count, total bacterial count, milk temperature of 8,101 samples of milk from expansion tanks and production of 78 farms located in the northern region of Minas Gerais, Brazil were processed. Descriptive statistical measures and Pearson correlation coefficient were estimated involving all evaluated traits during the dry and rainy seasons. In addition, multivariate analyses were performed using PCA. The results showed that two farm sites were negatively related to milk quality in both seasons. One farm stood out positively, being able to be used as a herd management model to drive technical assistance actions. Thus, PCA is efficient in simplifying large amounts of data, allowing simpler and faster technical herd management interpretation.
DOI: 10.6084/m9.figshare.20484570.v1
title: A principal component analysis required in technical assistance guidance for chilled raw milk producers

description: ABSTRACT. The purpose of the present study was to evaluate the principal component analysis (PCA) to guide technical assistance regarding several dairy farms’ issues, which includes improving microbiological quality and physical-chemical composition of raw refrigerated milk. Data of monthly analysis of fat, protein, lactose, dry defatted stratum, somatic cell count, total bacterial count, milk temperature of 8,101 samples of milk from expansion tanks and production of 78 farms located in the northern region of Minas Gerais, Brazil were processed. Descriptive statistical measures and Pearson correlation coefficient were estimated involving all evaluated traits during the dry and rainy seasons. In addition, multivariate analyses were performed using PCA. The results showed that two farm sites were negatively related to milk quality in both seasons. One farm stood out positively, being able to be used as a herd management model to drive technical assistance actions. Thus, PCA is efficient in simplifying large amounts of data, allowing simpler and faster technical herd management interpretation.
DOI: 10.6084/m9.figshare.20455260
title: Measuring optic nerve sheath diameter using ultrasonography in patients with idiopathic intracranial hypertension

description: Abstract Background: Idiopathic intracranial hypertension (IIH) is primarily a disorder of obese young women characterized by symptoms associated with raised intracranial pressure in the absence of a space-occupying lesion. Objective: To compare the mean optic nerve sheath diameter (ONSD) measured using ultrasonography (USG) in patients with idiopathic intracranial hypertension (IIH) and normal healthy individuals. Methods: A prospective study. Ninety-seven participants aged 18-80 years were divided into two groups as patients with IIH (n=47) and the control group (n=50). The ONSD was measured using ultrasound with a 10-MHz probe. ONSD was measured 3 mm behind the optic disc. Receiver operating characteristic (ROC) curve analysis was performed to determine patients with IIH using ONSD. Results: Body mass index was higher in the IIH group compared with the control group (p=0.001). The mean ONSD was statistically significantly thicker in the IIH group (6.4 mm) than in the control group (4.90 mm). The cut-off value of ONSD in patients with IIH was measured as 5.70 mm. There was a significant negative correlation between ONSD and age (r:-0.416 and p&lt;0.001). There was a positive correlation between BMI and ONSD (r: 0.437 and p&lt;0.001). Conclusions: Ultrasound can be a reliable, non-invasive and rapid tool to measure ONSD in monitoring patients with IIH. After the first diagnosis of IIH, based on neuroimaging and measuring intracranial pressure using invasive methods, ONSD can be used in treatment and follow-up.
DOI: 10.6084/m9.figshare.20455260.v1
title: Measuring optic nerve sheath diameter using ultrasonography in patients with idiopathic intracranial hypertension

description: Abstract Background: Idiopathic intracranial hypertension (IIH) is primarily a disorder of obese young women characterized by symptoms associated with raised intracranial pressure in the absence of a space-occupying lesion. Objective: To compare the mean optic nerve sheath diameter (ONSD) measured using ultrasonography (USG) in patients with idiopathic intracranial hypertension (IIH) and normal healthy individuals. Methods: A prospective study. Ninety-seven participants aged 18-80 years were divided into two groups as patients with IIH (n=47) and the control group (n=50). The ONSD was measured using ultrasound with a 10-MHz probe. ONSD was measured 3 mm behind the optic disc. Receiver operating characteristic (ROC) curve analysis was performed to determine patients with IIH using ONSD. Results: Body mass index was higher in the IIH group compared with the control group (p=0.001). The mean ONSD was statistically significantly thicker in the IIH group (6.4 mm) than in the control group (4.90 mm). The cut-off value of ONSD in patients with IIH was measured as 5.70 mm. There was a significant negative correlation between ONSD and age (r:-0.416 and p&lt;0.001). There was a positive correlation between BMI and ONSD (r: 0.437 and p&lt;0.001). Conclusions: Ultrasound can be a reliable, non-invasive and rapid tool to measure ONSD in monitoring patients with IIH. After the first diagnosis of IIH, based on neuroimaging and measuring intracranial pressure using invasive methods, ONSD can be used in treatment and follow-up.
DOI: 10.6084/m9.figshare.20484576
title: Managing Contagion: COVID-19, public health, and reflexive behavior

description: ABSTRACT This paper characterizes a pandemic as a kind of contagion, and describes a contagion as a two-level, two-direction, reflexive feedback loop system. In such a system, expert opinions for managing a pandemic can act as self-fulfilling prophecies due to how they influence collective belief formation. However, when multiple experts produce multiple expert opinions that act as self-fulfilling prophecies, this can fragment a society’s response to a pandemic, worsening rather than ameliorating it. This paper models this possible outcome by distinguishing two competing expert opinions, appealing respectively to people in club good and common pool types of employment/health insurance situations, and argues that to combat fragmentation of opinion about how to address a pandemic, public health policy needs to attend to the nature of public reasoning. It argues this entails asking how just and legitimate deliberative institutions can function in an ‘inclusive and noncoercive’ way that allows society to reconcile competing visions regarding how to combat system-wide crises such as pandemics.
DOI: 10.6084/m9.figshare.20484576.v1
title: Managing Contagion: COVID-19, public health, and reflexive behavior

description: ABSTRACT This paper characterizes a pandemic as a kind of contagion, and describes a contagion as a two-level, two-direction, reflexive feedback loop system. In such a system, expert opinions for managing a pandemic can act as self-fulfilling prophecies due to how they influence collective belief formation. However, when multiple experts produce multiple expert opinions that act as self-fulfilling prophecies, this can fragment a society’s response to a pandemic, worsening rather than ameliorating it. This paper models this possible outcome by distinguishing two competing expert opinions, appealing respectively to people in club good and common pool types of employment/health insurance situations, and argues that to combat fragmentation of opinion about how to address a pandemic, public health policy needs to attend to the nature of public reasoning. It argues this entails asking how just and legitimate deliberative institutions can function in an ‘inclusive and noncoercive’ way that allows society to reconcile competing visions regarding how to combat system-wide crises such as pandemics.