cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.16406189.v1
title: Report of a new <i>meq</i> gene size: The first study on genetic characterization of Marek’s disease viruses circulating in Iranian commercial layer and backyard chicken

description: In recent months, several outbreaks with clinical signs of MDV-1 were reported in Iranian parent and laying hen farms, in addition to backyard chickens. Several <i>meq</i> gene sequences from these outbreaks were amplified and molecularly characterised.The meq protein sequences revealed three different sizes, namely the standard 339 aa, a shorter form of 338 aa lacking a proline residue at position 191, and a very short (vs) size of 265 aa. Based on sequence and size, the 265 aa meq has never been reported from international research groups before. The protein has only one PPPP repeat motif suggesting it belongs to a highly virulent strain.The standard meq sequences showed 100% BLAST identity to the vv+ isolate Polen5. However, the 338 aa form clustered to the clade usually reported from North America.This is the first report on genetic analysis of MDV-1 from Iran, but further study is required to obtain a better picture of the diversity and prevalence of different MDV-1 strains circulating in the country’s farms, backyard poultry and/or other bird species. In recent months, several outbreaks with clinical signs of MDV-1 were reported in Iranian parent and laying hen farms, in addition to backyard chickens. Several <i>meq</i> gene sequences from these outbreaks were amplified and molecularly characterised. The meq protein sequences revealed three different sizes, namely the standard 339 aa, a shorter form of 338 aa lacking a proline residue at position 191, and a very short (vs) size of 265 aa. Based on sequence and size, the 265 aa meq has never been reported from international research groups before. The protein has only one PPPP repeat motif suggesting it belongs to a highly virulent strain. The standard meq sequences showed 100% BLAST identity to the vv+ isolate Polen5. However, the 338 aa form clustered to the clade usually reported from North America. This is the first report on genetic analysis of MDV-1 from Iran, but further study is required to obtain a better picture of the diversity and prevalence of different MDV-1 strains circulating in the country’s farms, backyard poultry and/or other bird species.
DOI: 10.6084/m9.figshare.15147935.v1
title: Transcriptome profiling reveals morphogenesis-related candidate genes and pathways in the chick embryonic small intestine

description: 1. A better understanding of intestinal development is essential for the intestinal health of poultry. Intestinal villification starts on embryo day E15 and is generally completed before hatching (E21). The development of lymphoid organs in the intestine starts during embryogenesis. However, transcriptional information on the processing of intestinal morphogenesis and immune development during chick embryogenesis is limited. 2. In this work, RNA-sequencing was performed using 12 biological replicates to investigate Hy-Line brown chick embryonic small intestinal transcription at E15 and E21. Differentially expressed genes (DEGs) between E15 and E21 were identified. GO and KEGG enrichment analyses, based on the DEGs, were performed to identify key GO terms in the biological process category and key KEGG pathways. PPI networks were constructed based on the DEGs in the key pathways to screen hub genes. The embryonic small intestinal morphology and IgA distribution were observed by histological processing. The serum levels of IgA and lysozyme were measured by ELISA. 3. A total of 76.38 Gb of high-quality RNA-sequencing data were generated and uploaded. A total of 2,676 DEGs, between E15 and E21, were identified. Structural development and villification of the small intestine at E15 tended to proceed <i>via</i> the expression of nervous system development-related genes. A combination of the histological and serological results with the transcriptome data indicated that the identified genes and pathways may be strong candidates for intestinal morphogenesis-regulation. The small intestine appears to have developed a relatively complete morphology and transport, metabolism, digestion and immunity functions by E21. This work provided a transcriptome profile of the chick embryonic small intestine and provided insights into the intestinal development and health of poultry.
DOI: 10.6084/m9.figshare.16818602.v1
title: Acute heat stress alters the expression of genes and proteins associated with the unfolded protein response pathway in the liver of broilers

description: 1. The aim of this study was to explore the effects of acute heat stress on serum hormone levels and the expression of genes and proteins related to the unfolded protein response (UPR) pathway and apoptotic process in the liver of broilers. 2. A total of 144 Arbor Acres broilers (35-d-old) were randomly allocated to 4 different environmental-controlled chambers for acute heat exposure. The temperature of the 4 environmental chambers was adjusted to 26°C (control), 29°C, 32°C, and 35°C within 1 h, respectively. The blood and liver samples were collected after 6 h of constant heat exposure at set temperatures. 3. The results showed that 6 h of acute heat stress increased serum hormone levels and up-regulated the expression of heat shock protein. The endoplasmic reticulum (ER) stress markers, GRP78 and GRP94, in the liver of broilers were significantly upregulated at the <i>mRNA</i> and protein levels. The <i>PERK, IRE1</i>, and <i>XBP1</i> genes, which are involved in the unfolded protein response signalling, were significantly up-regulated at the <i>mRNA</i> levels. However, other pro-apoptotic genes showed no significant changes in the liver of broiler chickens in all groups except for upregulation of the anti-apoptotic gene <i>BCL-xl</i>. 4. The results suggested that broilers have tolerance to acute heat stress to a certain extent. The UPR activation can alleviate ER stress and further prevent apoptosis in the liver of broilers under short-term exposure to high ambient temperatures.
DOI: 10.6084/m9.figshare.15147935
title: Transcriptome profiling reveals morphogenesis-related candidate genes and pathways in the chick embryonic small intestine

description: 1. A better understanding of intestinal development is essential for the intestinal health of poultry. Intestinal villification starts on embryo day E15 and is generally completed before hatching (E21). The development of lymphoid organs in the intestine starts during embryogenesis. However, transcriptional information on the processing of intestinal morphogenesis and immune development during chick embryogenesis is limited. 2. In this work, RNA-sequencing was performed using 12 biological replicates to investigate Hy-Line brown chick embryonic small intestinal transcription at E15 and E21. Differentially expressed genes (DEGs) between E15 and E21 were identified. GO and KEGG enrichment analyses, based on the DEGs, were performed to identify key GO terms in the biological process category and key KEGG pathways. PPI networks were constructed based on the DEGs in the key pathways to screen hub genes. The embryonic small intestinal morphology and IgA distribution were observed by histological processing. The serum levels of IgA and lysozyme were measured by ELISA. 3. A total of 76.38 Gb of high-quality RNA-sequencing data were generated and uploaded. A total of 2,676 DEGs, between E15 and E21, were identified. Structural development and villification of the small intestine at E15 tended to proceed <i>via</i> the expression of nervous system development-related genes. A combination of the histological and serological results with the transcriptome data indicated that the identified genes and pathways may be strong candidates for intestinal morphogenesis-regulation. 4. The small intestine appears to have developed a relatively complete morphology and transport, metabolism, digestion and immunity functions by E21. This work provided a transcriptome profile of the chick embryonic small intestine and provided insights into the intestinal development and health of poultry.
DOI: 10.25398/rd.northumbria.19361453
title: Narrative Elaboration and misinformation regarding COVID-19

description: Data set from 80 participants. Statements contained misinformation and true statements regarding COVID-19. Statements were also accompanied by narrative elaboration that expanded on the text. Participants had to rate each statement for believability and willingness to share the statement online. Greater scores indicated greater believability and a greater willingness to share the statement. Data were analysed using paired samples t-tests and correlations. Participants were also grouped by age with younger adults aged 18-34 and older adults aged 35 and over. Age effects were analysed using independent samples t-tests.
DOI: 10.25398/rd.northumbria.19361453.v1
title: Narrative Elaboration and misinformation regarding COVID-19

description: Data set from 80 participants. Statements contained misinformation and true statements regarding COVID-19. Statements were also accompanied by narrative elaboration that expanded on the text. Participants had to rate each statement for believability and willingness to share the statement online. Greater scores indicated greater believability and a greater willingness to share the statement. Data were analysed using paired samples t-tests and correlations. Participants were also grouped by age with younger adults aged 18-34 and older adults aged 35 and over. Age effects were analysed using independent samples t-tests.
DOI: 10.6084/m9.figshare.19368923
title: Factor loads

description: Factor loads
DOI: 10.5281/zenodo.6362743
title: SciExpeM - 10.5281/zenodo.6362743

description: Tang, Chenglong; Wei, Liangjie; Man, Xingjia; Zhang, Jiaxiang; Huang, Zuohua; Law, Chung K. - Combustion And Flame, 2013, (160), 520-529
DOI: 10.5281/zenodo.6362742
title: SciExpeM - 10.5281/zenodo.6362743

description: Tang, Chenglong; Wei, Liangjie; Man, Xingjia; Zhang, Jiaxiang; Huang, Zuohua; Law, Chung K. - Combustion And Flame, 2013, (160), 520-529
DOI: 10.6084/m9.figshare.19368959
title: Goldfeld-Quandt test values

description: Goldfeld-Quandt test values
DOI: 10.48420/19181288
title: Bamber Thesis: Understanding Basaltic Plinian Eruptions

description: Supplementary data for the thesis Understanding Basaltic Plinian Eruptions.
DOI: 10.48420/19181288.v1
title: Bamber Thesis: Understanding Basaltic Plinian Eruptions

description: Supplementary data for the thesis Understanding Basaltic Plinian Eruptions.
DOI: 10.17037/data.00002824
title: Clinical codelist - CPRD Aurum - chronic kidney disease

description: SNOMED codes for a clinical diagnosis of, or clinical review specific to, CKD stages 3-5, history of dialysis or renal transplant.
DOI: 10.6084/m9.figshare.19368845
title: HDAC class I inhibitor domatinostat sensitizes pancreatic cancer to chemotherapy by targeting cancer stem cell compartment via FOXM1 modulation

description: Raw data related to the paper: Roca MS, Moccia T, Iannelli F, Testa C, Vitagliano C, Minopoli M, Camerlingo R, De Riso G, De Cecio R, Bruzzese F, Conte M, Altucci L, Di Gennaro E, Avallone A, Leone A, Budillon A. HDAC class I inhibitor domatinostat sensitizes pancreatic cancer to chemotherapy by targeting cancer stem cell compartment via FOXM1 modulation. J Exp Clin Cancer Res. 2022 Mar 3;41(1):83.
DOI: 10.6084/m9.figshare.19368845.v1
title: HDAC class I inhibitor domatinostat sensitizes pancreatic cancer to chemotherapy by targeting cancer stem cell compartment via FOXM1 modulation

description: Raw data related to the paper: Roca MS, Moccia T, Iannelli F, Testa C, Vitagliano C, Minopoli M, Camerlingo R, De Riso G, De Cecio R, Bruzzese F, Conte M, Altucci L, Di Gennaro E, Avallone A, Leone A, Budillon A. HDAC class I inhibitor domatinostat sensitizes pancreatic cancer to chemotherapy by targeting cancer stem cell compartment via FOXM1 modulation. J Exp Clin Cancer Res. 2022 Mar 3;41(1):83.
DOI: 10.5281/zenodo.6362775
title: SciExpeM - 10.5281/zenodo.6362775

description: Tang, Chenglong; Wei, Liangjie; Man, Xingjia; Zhang, Jiaxiang; Huang, Zuohua; Law, Chung K. - Combustion And Flame, 2013, (160), 520-529
DOI: 10.5281/zenodo.6362774
title: SciExpeM - 10.5281/zenodo.6362775

description: Tang, Chenglong; Wei, Liangjie; Man, Xingjia; Zhang, Jiaxiang; Huang, Zuohua; Law, Chung K. - Combustion And Flame, 2013, (160), 520-529
DOI: 10.17037/data.00002825
title: Clinical codelist - CPRD Aurum - systemic lupus erythematosus

description: SNOMED codes for a clinical diagnosis of systemic lupus erythematosus.
DOI: 10.5281/zenodo.6362653
title: Effects of air pollution exposure on inflammatory and endurance performance in recreationally trained cyclists adapted to traffic-related air pollution

description: Supplementary Table 2. Baseline values for blood parameters.
description: This study was financed in part by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - Brasil (CAPES) - Finance Code 001. Coordination of Superior Level Staff Improvement - Academic Excellence Program (CAPES-PROEX). André C. Silveira was supported by a Sao Paulo Research Foundation scholarship (FAPESP – Grant: 2018/21600-0). Luisa Giles was supported by Research Incentive Grant (no grant number). Romulo Bertuzzi was supported by a grant from the National Council for Scientific and Technological Development (CNPq 301330/2019-0).
DOI: 10.6084/m9.figshare.17338394.v1
title: Database as of November 27, 2021

description: This file contains the database in SQLite format as of November 27, 2021. A live version of the database, which continues to be updated, is available at https://covid19datahub.io
DOI: 10.6084/m9.figshare.19178720
title: Data Sources as of November 27, 2021

description: This file contains the data sources in PDF format as of November 27, 2021. A live version of the database, which continues to be updated, is available at https://covid19datahub.io
DOI: 10.6084/m9.figshare.19178720.v1
title: Data Sources as of November 27, 2021

description: This file contains the data sources in PDF format as of November 27, 2021. A live version of the database, which continues to be updated, is available at https://covid19datahub.io
DOI: 10.6084/m9.figshare.17338394
title: Database as of November 27, 2021

description: This file contains the database in SQLite format as of November 27, 2021. A live version of the database, which continues to be updated, is available at https://covid19datahub.io
DOI: 10.6084/m9.figshare.19368305.v2
title: Supplementary Tables (S1-S5).docx

description: <b>Supplementary Tables: Table S1-S4</b>
DOI: 10.6084/m9.figshare.19368305
title: Supplementary Tables (S1-S5).docx

description: <b>Supplementary Tables: Table S1-S4</b>
DOI: 10.6084/m9.figshare.19368305.v1
title: Supplememntary Tables (S1-S5).docx

description: <b>Supplementary Tables: Table S1-S4</b>
DOI: 10.5281/zenodo.6362428
title: Validating x-ray line-profile defect analysis using atomistic models of deformed material

description: Data and analysis (scripts and Jupyter notebooks) associated with publications: Validating x-ray line-profile defect analysis using atomistic models of deformed material (submitted to Physical Review Materials) Validation of x-ray line-profile analysis of extended defects in deformed crystals (submitted to Physical Review Letters) Preprints of these papers are included here
DOI: 10.5281/zenodo.6362427
title: Validating x-ray line-profile defect analysis using atomistic models of deformed material

description: Data and analysis (scripts and Jupyter notebooks) associated with publications: Validating x-ray line-profile defect analysis using atomistic models of deformed material (submitted to Physical Review Materials) Validation of x-ray line-profile analysis of extended defects in deformed crystals (submitted to Physical Review Letters) Preprints of these papers are included here
DOI: 10.6073/pasta/702debb6cbc1e7875427edb99b5b06cd
title: PIE LTER water-column nutrient and particulate transects along the Rowley River Estuary, Massachusetts, 2017-2019

description: Water chemistry including nutrient concentrations for various forms of N, P, C, as well as suspended sediments and light extinction coefficients, are determined from bi-annual or tri-annual nutrient transects from the mouth of the Rowely River estuary to near its head about 6 km upstream. Three sets of grab samples and sonde measurements are taken at lower, mid, and upper stations of the estuary, at stations locations that may vary depending on the tide. These samples are generally collected in Spring, Summer, and Fall to capture conditions through the growing season.
DOI: 10.5281/zenodo.6362807
title: SciExpeM - 10.5281/zenodo.6362807

description: Tang, Chenglong; Wei, Liangjie; Man, Xingjia; Zhang, Jiaxiang; Huang, Zuohua; Law, Chung K. - Combustion And Flame, 2013, (160), 520-529
DOI: 10.5281/zenodo.6362806
title: SciExpeM - 10.5281/zenodo.6362807

description: Tang, Chenglong; Wei, Liangjie; Man, Xingjia; Zhang, Jiaxiang; Huang, Zuohua; Law, Chung K. - Combustion And Flame, 2013, (160), 520-529
DOI: 10.34820/fk2/vnpstz/sdzadi
title: Data Subdomain UKM Telkom University tahun 2021.tab

description: Data subdomain unit kegiatan mahasiswa di Telkom University tahun 2021 Data subdomain unit kegiatan mahasiswa di Telkom University, UKM perlu diberikan wadah promosi yaitu berupa website, agar seluruh kegitan UKM bersangkutan tercata, bisa jadi ajang branding meningkatkan anggota UKM, laporan akreditasi, dan branding kampus secara umum.
DOI: 10.34820/fk2/vnpstz
title: Subdomain Website Telkom University

description: Data subdomain website di Telkom University, Semua unit kegitan bahkan hingga UKM mahasiswa perlu diberikan wadah promosi yaitu berupa website, agar seluruh kegitan bersangkutan tercatat, bisa jadi ajang branding meningkatkan anggota civitas academica, laporan akreditasi, dan branding kampus secara umum.
DOI: 10.5517/ccdc.csd.cc2bbtm4
title: CCDC 2155356: Experimental Crystal Structure Determination

description: Related Article: M. Chodkiewicz, S. Pawlędzio, M. Woińska, K. Woźniak|2022|IUCrJ|9|298|doi:10.1107/S2052252522000690
DOI: 10.5517/ccdc.csd.cc2bbtn5
title: CCDC 2155357: Experimental Crystal Structure Determination

description: Related Article: M. Chodkiewicz, S. Pawlędzio, M. Woińska, K. Woźniak|2022|IUCrJ|9|298|doi:10.1107/S2052252522000690
DOI: 10.5517/ccdc.csd.cc2bbtp6
title: CCDC 2155358: Experimental Crystal Structure Determination

description: Related Article: M. Chodkiewicz, S. Pawlędzio, M. Woińska, K. Woźniak|2022|IUCrJ|9|298|doi:10.1107/S2052252522000690
DOI: 10.5517/ccdc.csd.cc2bbtq7
title: CCDC 2155359: Experimental Crystal Structure Determination

description: Related Article: M. Chodkiewicz, S. Pawlędzio, M. Woińska, K. Woźniak|2022|IUCrJ|9|298|doi:10.1107/S2052252522000690
DOI: 10.5517/ccdc.csd.cc2bbtr8
title: CCDC 2155360: Experimental Crystal Structure Determination

description: Related Article: M. Chodkiewicz, S. Pawlędzio, M. Woińska, K. Woźniak|2022|IUCrJ|9|298|doi:10.1107/S2052252522000690
DOI: 10.5517/ccdc.csd.cc2bbts9
title: CCDC 2155361: Experimental Crystal Structure Determination

description: Related Article: M. Chodkiewicz, S. Pawlędzio, M. Woińska, K. Woźniak|2022|IUCrJ|9|298|doi:10.1107/S2052252522000690
DOI: 10.5517/ccdc.csd.cc2bbttb
title: CCDC 2155362: Experimental Crystal Structure Determination

description: Related Article: M. Chodkiewicz, S. Pawlędzio, M. Woińska, K. Woźniak|2022|IUCrJ|9|298|doi:10.1107/S2052252522000690
DOI: 10.5517/ccdc.csd.cc2bbtvc
title: CCDC 2155363: Experimental Crystal Structure Determination

description: Related Article: M. Chodkiewicz, S. Pawlędzio, M. Woińska, K. Woźniak|2022|IUCrJ|9|298|doi:10.1107/S2052252522000690
DOI: 10.5517/ccdc.csd.cc2bbtwd
title: CCDC 2155364: Experimental Crystal Structure Determination

description: Related Article: M. Chodkiewicz, S. Pawlędzio, M. Woińska, K. Woźniak|2022|IUCrJ|9|298|doi:10.1107/S2052252522000690
DOI: 10.5517/ccdc.csd.cc2bbtxf
title: CCDC 2155365: Experimental Crystal Structure Determination

description: Related Article: M. Chodkiewicz, S. Pawlędzio, M. Woińska, K. Woźniak|2022|IUCrJ|9|298|doi:10.1107/S2052252522000690
DOI: 10.5517/ccdc.csd.cc2bbtyg
title: CCDC 2155366: Experimental Crystal Structure Determination

description: Related Article: M. Chodkiewicz, S. Pawlędzio, M. Woińska, K. Woźniak|2022|IUCrJ|9|298|doi:10.1107/S2052252522000690
DOI: 10.5517/ccdc.csd.cc2bbtzh
title: CCDC 2155367: Experimental Crystal Structure Determination

description: Related Article: M. Chodkiewicz, S. Pawlędzio, M. Woińska, K. Woźniak|2022|IUCrJ|9|298|doi:10.1107/S2052252522000690
DOI: 10.5517/ccdc.csd.cc2bbv0k
title: CCDC 2155368: Experimental Crystal Structure Determination

description: Related Article: M. Chodkiewicz, S. Pawlędzio, M. Woińska, K. Woźniak|2022|IUCrJ|9|298|doi:10.1107/S2052252522000690
DOI: 10.5517/ccdc.csd.cc2bbv1l
title: CCDC 2155369: Experimental Crystal Structure Determination

description: Related Article: M. Chodkiewicz, S. Pawlędzio, M. Woińska, K. Woźniak|2022|IUCrJ|9|298|doi:10.1107/S2052252522000690
DOI: 10.5517/ccdc.csd.cc2bbv2m
title: CCDC 2155370: Experimental Crystal Structure Determination

description: Related Article: M. Chodkiewicz, S. Pawlędzio, M. Woińska, K. Woźniak|2022|IUCrJ|9|298|doi:10.1107/S2052252522000690
DOI: 10.5517/ccdc.csd.cc2bbv3n
title: CCDC 2155371: Experimental Crystal Structure Determination

description: Related Article: M. Chodkiewicz, S. Pawlędzio, M. Woińska, K. Woźniak|2022|IUCrJ|9|298|doi:10.1107/S2052252522000690
DOI: 10.5517/ccdc.csd.cc2bbv4p
title: CCDC 2155372: Experimental Crystal Structure Determination

description: Related Article: M. Chodkiewicz, S. Pawlędzio, M. Woińska, K. Woźniak|2022|IUCrJ|9|298|doi:10.1107/S2052252522000690
DOI: 10.5517/ccdc.csd.cc2bbv5q
title: CCDC 2155373: Experimental Crystal Structure Determination

description: Related Article: M. Chodkiewicz, S. Pawlędzio, M. Woińska, K. Woźniak|2022|IUCrJ|9|298|doi:10.1107/S2052252522000690
DOI: 10.5517/ccdc.csd.cc2bbv6r
title: CCDC 2155374: Experimental Crystal Structure Determination

description: Related Article: M. Chodkiewicz, S. Pawlędzio, M. Woińska, K. Woźniak|2022|IUCrJ|9|298|doi:10.1107/S2052252522000690
DOI: 10.5517/ccdc.csd.cc2bbv7s
title: CCDC 2155375: Experimental Crystal Structure Determination

description: Related Article: M. Chodkiewicz, S. Pawlędzio, M. Woińska, K. Woźniak|2022|IUCrJ|9|298|doi:10.1107/S2052252522000690
DOI: 10.5517/ccdc.csd.cc2bbv8t
title: CCDC 2155376: Experimental Crystal Structure Determination

description: Related Article: M. Chodkiewicz, S. Pawlędzio, M. Woińska, K. Woźniak|2022|IUCrJ|9|298|doi:10.1107/S2052252522000690
DOI: 10.5517/ccdc.csd.cc2bbv9v
title: CCDC 2155377: Experimental Crystal Structure Determination

description: Related Article: M. Chodkiewicz, S. Pawlędzio, M. Woińska, K. Woźniak|2022|IUCrJ|9|298|doi:10.1107/S2052252522000690
DOI: 10.5517/ccdc.csd.cc2bbvbw
title: CCDC 2155378: Experimental Crystal Structure Determination

description: Related Article: M. Chodkiewicz, S. Pawlędzio, M. Woińska, K. Woźniak|2022|IUCrJ|9|298|doi:10.1107/S2052252522000690
DOI: 10.5517/ccdc.csd.cc2bbrp4
title: CCDC 2155296: Experimental Crystal Structure Determination

description: Related Article: M. Chodkiewicz, S. Pawlędzio, M. Woińska, K. Woźniak|2022|IUCrJ|9|298|doi:10.1107/S2052252522000690
DOI: 10.5517/ccdc.csd.cc2bbrq5
title: CCDC 2155297: Experimental Crystal Structure Determination

description: Related Article: M. Chodkiewicz, S. Pawlędzio, M. Woińska, K. Woźniak|2022|IUCrJ|9|298|doi:10.1107/S2052252522000690
DOI: 10.5517/ccdc.csd.cc2bbrr6
title: CCDC 2155298: Experimental Crystal Structure Determination

description: Related Article: M. Chodkiewicz, S. Pawlędzio, M. Woińska, K. Woźniak|2022|IUCrJ|9|298|doi:10.1107/S2052252522000690
DOI: 10.5517/ccdc.csd.cc2bby3r
title: CCDC 2155464: Experimental Crystal Structure Determination

description: Related Article: W. Clegg, Z. Yuan|2022|CSD Communication|||