cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.9598931.v1
title: The Effects of pH Values on Functional Mechanisms of Nitrite Anions for Q235 Carbon Steels in 0.01 mol L-1 NaNO2-HCl Solutions

description: For Q235 carbon steels in 0.01 mol L-1 NaNO2-HCl solutions with different pH values, the effects of pH values on the functional mechanisms of nitrite anions (NO2-) were studied. In the pH 1 and pH 2 solutions, the Q235 steels showed the electrochemical behavior of activation, and uniform corrosion (UC) was the main corrosion type on the Q235 surface. The presence of NO2- did not affect the electrochemical behavior and the corrosion type but only accelerated the anodic reaction of Fe oxidation. In the pH 3 and pH 4 solutions, the Q235 steels presented the electrochemical behavior of activation-passivation transition, and intergranular corrosion (IGC) occurred on the Q235 surface. The cathodic reaction of NO2- reduction resulted in the transition of electrochemical behavior from activation to passivation and the change of corrosion type from UC to IGC. In the pH 5 and pH 6 solutions, the Q235 steels exhibited the electrochemical behavior of self passivation-pitting, and pitting corrosion (PC) was present on the Q235 surface. The strong oxidability of NO2- played a critical role in the formation of γ-Fe2O3 passive film on the Q235 surface under the combined action of Fe2+ and NO2-.
DOI: 10.6084/m9.figshare.11171801
title: Prediction of Alzheimer’s disease with serum lipid levels in Asian individuals: a meta-analysis

description: <b>Background:</b> The serum lipid profile has become a routine clinical test and used as an important predictor for Alzheimer’s disease (AD), although its predictive value remains undetermined. <b>Objective:</b> To evaluate the role of serum lipid levels in predicting the risk of AD. <b>Methods:</b> Meta-analyses were conducted using Comprehensive Meta-analyses (CMA) software to investigate the association between four conventional serum lipid profile parameters and the risk of AD, focused on samples from Asian. <b>Results:</b> In total, 3423 AD patients and 6127 healthy participants were involved. The results demonstrated that AD patients showed higher LDL-C and TC levels (SMD = 0.27, 95% CI: 0.04–0.51, <i>p</i> = 0.02 for LDL-C; SMD = 0.25, 95% CI: 0.05–0.46, <i>p</i> = 0.02 for TC) compared with those of healthy controls. People with higher LDL-C and/or TC levels had an increased risk of AD (OR = 1.64, 95% CI: 1.07–2.51 for LDL-C and OR = 1.58, 95% CI: 1.10–2.92 for TC). <b>Conclusions:</b> This study provided evidence that serum LDL-C and TC levels were associated with the risk of AD in Asian individuals. The routine lipid profile may be useful for AD diagnosis, monitoring and treatment.
DOI: 10.6084/m9.figshare.11171801.v1
title: Prediction of Alzheimer’s disease with serum lipid levels in Asian individuals: a meta-analysis

description: <b>Background:</b> The serum lipid profile has become a routine clinical test and used as an important predictor for Alzheimer’s disease (AD), although its predictive value remains undetermined. <b>Objective:</b> To evaluate the role of serum lipid levels in predicting the risk of AD. <b>Methods:</b> Meta-analyses were conducted using Comprehensive Meta-analyses (CMA) software to investigate the association between four conventional serum lipid profile parameters and the risk of AD, focused on samples from Asian. <b>Results:</b> In total, 3423 AD patients and 6127 healthy participants were involved. The results demonstrated that AD patients showed higher LDL-C and TC levels (SMD = 0.27, 95% CI: 0.04–0.51, <i>p</i> = 0.02 for LDL-C; SMD = 0.25, 95% CI: 0.05–0.46, <i>p</i> = 0.02 for TC) compared with those of healthy controls. People with higher LDL-C and/or TC levels had an increased risk of AD (OR = 1.64, 95% CI: 1.07–2.51 for LDL-C and OR = 1.58, 95% CI: 1.10–2.92 for TC). <b>Conclusions:</b> This study provided evidence that serum LDL-C and TC levels were associated with the risk of AD in Asian individuals. The routine lipid profile may be useful for AD diagnosis, monitoring and treatment.
DOI: 10.6084/m9.figshare.9598976
title: Protective effects of salidroside on chronic heart failure in rats and the underlying mechanisms

description: The present study aimed to investigate the protective effects of salidroside on chronic heart failure (CHF) in rats and to explore the underlying mechanisms. One hundred SD rats were randomly divided into sham-operated, model, and low-, medium- and high-dose salidroside groups. The CHF model was established in later 4 groups. The later 3 groups were intragastrically administrated with 6, 12 and 24 mg/kg salidroside, respectively, once a day, for continuous 4 weeks. Finally, the serum levels of brain natriuretic peptide (BNP) and interleukin 6 (IL-6), cardiac function indexes, and expression levels of myocardial cysteinyl aspartate-specific proteinase (Caspase)-3, Caspase-9, matrix metalloproteinase-1 (MMP-1) and tissue inhibitor of metalloproteinase-1 (TIMP-1) protein were determined. Results showed that, after treatment, compared with model group, in high-dose salidroside group the heart function indexes were significantly improved (P &lt; 0.05), the serum levels of BNP and IL-6 were significantly decreased (P &lt; 0.05), the expression levels of myocardial Caspase-3, Caspase-9 and MMP-1 protein were significantly decreased (P &lt; 0.05), and the expression level of TIMP-1 protein was significantly increased (P &lt; 0.05). In conclusion, salidroside has obvious protective effects on CHF in rats. The mechanisms may be related to its regulation of cardiomyocyte apoptosis and ventricular remodelingregulation related protein expressions.
DOI: 10.6084/m9.figshare.9598976.v1
title: Protective effects of salidroside on chronic heart failure in rats and the underlying mechanisms

description: The present study aimed to investigate the protective effects of salidroside on chronic heart failure (CHF) in rats and to explore the underlying mechanisms. One hundred SD rats were randomly divided into sham-operated, model, and low-, medium- and high-dose salidroside groups. The CHF model was established in later 4 groups. The later 3 groups were intragastrically administrated with 6, 12 and 24 mg/kg salidroside, respectively, once a day, for continuous 4 weeks. Finally, the serum levels of brain natriuretic peptide (BNP) and interleukin 6 (IL-6), cardiac function indexes, and expression levels of myocardial cysteinyl aspartate-specific proteinase (Caspase)-3, Caspase-9, matrix metalloproteinase-1 (MMP-1) and tissue inhibitor of metalloproteinase-1 (TIMP-1) protein were determined. Results showed that, after treatment, compared with model group, in high-dose salidroside group the heart function indexes were significantly improved (P &lt; 0.05), the serum levels of BNP and IL-6 were significantly decreased (P &lt; 0.05), the expression levels of myocardial Caspase-3, Caspase-9 and MMP-1 protein were significantly decreased (P &lt; 0.05), and the expression level of TIMP-1 protein was significantly increased (P &lt; 0.05). In conclusion, salidroside has obvious protective effects on CHF in rats. The mechanisms may be related to its regulation of cardiomyocyte apoptosis and ventricular remodelingregulation related protein expressions.
DOI: 10.6084/m9.figshare.9598991
title: Curcumin combining with si-MALAT1 inhibits the invasion and migration of colon cancer SW480 cells

description: To study the effect of small interfering RNA targeting metastasis-associated lung adenocarcinoma transcript1 (si-MALAT1) combining with curcumin on the invasion and migration abilities of human colon cancer SW480 cells, and to explore the involved molecular mechanism. The recombinant lentiviral vector expressing si-MALAT1 was constructed, and its titer was determined by gradient dilution method. The colon cancer SW480 cells with stable expression of si-MALAT1 was established, followed by treatment with curcumin at different concentrations. The effect of curcumin or si-MALAT1 alone and the combination of the two on the cell activity was detected by MTT assay. The cell invasion and migration abilities were detected by transwell and scratch-wound assay. The relative expression level of MALAT1 was detected by RT-qPCR. The protein expression was determined by Western blot analysis. The IC50 of curcumin alone was 77.69 mmol/L, which was 51.17 mol/L when combined with curcumin and random sequence. The IC50 of curcumin was 30.02 mmol/L when combined with si-MALAT1. The increased susceptibility multiples was 2.58. The wound healing rates were 30.9% and 67.5% after treatment with si-MALAT1 combined with curcumin for 24 hrs and 48 hrs, respectively. The numbers of invasion cells were 200±12, 162±13, 66±8, 53±4 and 16±3 after treatment with si-MALAT1 combined with curcumin for 48 hrs. The relative expression level of lncRNA-MALAT1 in the curcumin group was 68%, and the relative expression level of lncRNA-MALAT1 in si-MALAT1group was 56%, and that for the combination treatment group was about 21%. The protein expression levels of β- catenin, c-myc and cyclinD1 were significantly down-regulated upon treatment with certain concentration of si-MALAT1 alone or combined with curcumin.si-MALAT1 could significantly inhibit the invasion and migration of SW480 cells by enhancing the sensitivity of SW480 cells to curcumin. The mechanism involved mignt be related to the down-regulation of β-catenin, c-myc and cyclinD1 proteins.
DOI: 10.6084/m9.figshare.9598991.v1
title: Curcumin combining with si-MALAT1 inhibits the invasion and migration of colon cancer SW480 cells

description: To study the effect of small interfering RNA targeting metastasis-associated lung adenocarcinoma transcript1 (si-MALAT1) combining with curcumin on the invasion and migration abilities of human colon cancer SW480 cells, and to explore the involved molecular mechanism. The recombinant lentiviral vector expressing si-MALAT1 was constructed, and its titer was determined by gradient dilution method. The colon cancer SW480 cells with stable expression of si-MALAT1 was established, followed by treatment with curcumin at different concentrations. The effect of curcumin or si-MALAT1 alone and the combination of the two on the cell activity was detected by MTT assay. The cell invasion and migration abilities were detected by transwell and scratch-wound assay. The relative expression level of MALAT1 was detected by RT-qPCR. The protein expression was determined by Western blot analysis. The IC50 of curcumin alone was 77.69 mmol/L, which was 51.17 mol/L when combined with curcumin and random sequence. The IC50 of curcumin was 30.02 mmol/L when combined with si-MALAT1. The increased susceptibility multiples was 2.58. The wound healing rates were 30.9% and 67.5% after treatment with si-MALAT1 combined with curcumin for 24 hrs and 48 hrs, respectively. The numbers of invasion cells were 200±12, 162±13, 66±8, 53±4 and 16±3 after treatment with si-MALAT1 combined with curcumin for 48 hrs. The relative expression level of lncRNA-MALAT1 in the curcumin group was 68%, and the relative expression level of lncRNA-MALAT1 in si-MALAT1group was 56%, and that for the combination treatment group was about 21%. The protein expression levels of β- catenin, c-myc and cyclinD1 were significantly down-regulated upon treatment with certain concentration of si-MALAT1 alone or combined with curcumin.si-MALAT1 could significantly inhibit the invasion and migration of SW480 cells by enhancing the sensitivity of SW480 cells to curcumin. The mechanism involved mignt be related to the down-regulation of β-catenin, c-myc and cyclinD1 proteins.
DOI: 10.6084/m9.figshare.22181926
title: Data to produce the Figures in "Efficient scattering loss of energetic electrons by enhanced higher-band ECH waves observed by Van Allen Probes"

description: Electron cyclotron harmonic (ECH) waves, which are responsible for the diffuse aurora, are usually observed with the strongest intensity in the first band. Here, we present observations of enhanced higher-band ECH with wave amplitudes ~1 mV/m by Van Allen Probes. Fully thermal simulation results indicate that these waves can be locally excited by the observed electron distributions, and higher plasma densities and lower magnetic strength are beneficial for exciting the higher-band ECH. The pitch angle diffusion coefficient of the higher-band ECH can approach 10^-3 s^-1 for energetic electrons (~300 eV -- 10 keV), greater than the momentum diffusion coefficient by ~100 times. It is suggested that the enhanced higher-band ECH can also efficiently scatter these electrons into the loss cone and contribute to the diffuse aurora.
DOI: 10.6084/m9.figshare.24803370
title: Supplementary information for "Role of DNMT1 and C/EBPα in the regulation CYP11A1 expression during syncytialization of human placental trophoblasts"

description: Supplementary information (figures and tables) for<b> </b>"Role of DNMT1 and C/EBPα in the regulation CYP11A1 expression during syncytialization of human placental trophoblasts" by Ya-Nan Zhu, Fan Pan, Xiao-Wen Gan, Yun Liu, Wang-Sheng Wang*, Kang Sun*
DOI: 10.6084/m9.figshare.9599027
title: Electrochemical Impedance Biosensor for the Determination of Lipopolysaccharide Using Peptide as the Recognition Molecule

description: A simple and sensitive electrochemical impedance spectroscopy (EIS) biosensor was designed for the determination of lipopolysaccharide (LPS). The gold nanoparticles (GNPs) were electrochemically deposited on the glassy carbon electrode as a base electrode and the biosensor was fabricated by self-assembling a special peptide (GIGKLHSAGKF) used as molecular recognition onto the GNPs surface according to the Au–S bond. Polyethylene glycol and 6-mercapto-1-hexanol were used to block the remaining sites of the modified electrode surface. When binding of LPS, the biosensor had a good response to different concentrations of LPS and the charge transfer resistance of the biosensor was directly related to the logarithm of LPS concentrations in the range of 0.01 pg mL-1-1.0 ng mL-1 with a limit of detection of 2.0 fg mL-1. The characteristics of the electrochemically deposited GNPs and the optimization concentration and the self-assembly time of peptide, as well as the performance of the EIS biosensors for LPS were investigated. The biosensor was used for real serum sample determination with satisfactory results.
DOI: 10.6084/m9.figshare.9599027.v1
title: Electrochemical Impedance Biosensor for the Determination of Lipopolysaccharide Using Peptide as the Recognition Molecule

description: A simple and sensitive electrochemical impedance spectroscopy (EIS) biosensor was designed for the determination of lipopolysaccharide (LPS). The gold nanoparticles (GNPs) were electrochemically deposited on the glassy carbon electrode as a base electrode and the biosensor was fabricated by self-assembling a special peptide (GIGKLHSAGKF) used as molecular recognition onto the GNPs surface according to the Au–S bond. Polyethylene glycol and 6-mercapto-1-hexanol were used to block the remaining sites of the modified electrode surface. When binding of LPS, the biosensor had a good response to different concentrations of LPS and the charge transfer resistance of the biosensor was directly related to the logarithm of LPS concentrations in the range of 0.01 pg mL-1-1.0 ng mL-1 with a limit of detection of 2.0 fg mL-1. The characteristics of the electrochemically deposited GNPs and the optimization concentration and the self-assembly time of peptide, as well as the performance of the EIS biosensors for LPS were investigated. The biosensor was used for real serum sample determination with satisfactory results.
DOI: 10.6084/m9.figshare.19556331.v1
title: Additional file 2 of Bioinformatics analysis reveals immune prognostic markers for overall survival of colorectal cancer patients: a novel machine learning survival predictive system

description: Additional file 2. Gene enrichment analysis dataset.
DOI: 10.6084/m9.figshare.19560517
title: New Model-Free Daily Inversion of NOx Emissions using TROPOMI (MCMFE-NOx) and its Uncertainty: Deducing a See-Saw of Halved Well Regulated Sources and Doubled New Sources

description: This dataset contains all of the data underlying the figures in the accompanying paper "New Model-Free Daily Inversion of NOx Emissions using TROPOMI (MCMFE-NOx) and its Uncertainty: Deducing a See-Saw of Halved Well Regulated Sources and Doubled New Sources".
These are listed respectively under: 
Coefficients.zip
Figure3.zip
Figure4.zip
Figure5.zip
Figure6.zip
Figure7.zip
Figure8.zip
Figure9.zip
Figure10.zip
All data is provided as .nc files, and all plots are provided as .png files. All emissions are provided as a part of Figure6.zip in .nc format, to be consistent with the paper.
DOI: 10.6084/m9.figshare.21657677
title: Supplimentary data for Triplophysa wudangensis and Triplophysa qingzhenensis

description: Two hypogean species of <em>Triplophysa</em> from the River Yangtze drainage, <em>T. wudangensis and T. qingzhenensis </em>were described in Journal of vertebrate biology. This is the supplimentary data for the two species.
DOI: 10.6084/m9.figshare.8026190
title: CMC data accession number

description: The accession number of CMC data used in the study
DOI: 10.6084/m9.figshare.8026229
title: Detection of circular RNA expression and related quantitative trait loci in the human dorsolateral prefrontal cortex

description: The Additional files of "Detection of circular RNA expression and related quantitative trait loci in the human dorsolateral prefrontal cortex"
DOI: 10.6084/m9.figshare.9599120
title: Ginsenoside Rd inhibits IL-1β-induced inflammation and degradation of intervertebral disc chondrocytes by increasing IL1RAP ubiquitination

description: Many compounds of ginsenosides show anti-inflammatory properties. However, their anti-inflammatory effects in intervertebral chondrocytes in the presence of inflammatory factors have never been shown. Increased levels of pro-inflammatory cytokines are generally associated with the degradation and death of chondrocytes; therefore, finding an effective and nontoxic substance that attenuates the inflammation is worthwhile. In this study, chondrocytes were isolated from the nucleus pulposus tissues, and the cells were treated with ginsenoside compounds and IL-1β, alone and in combination. Cell viability and death rate were assessed by CCK-8 and flow cytometry methods, respectively. PCR, western blot, and immunoprecipitation assays were performed to determine the mRNA and protein expression, and the interactions between proteins, respectively. Monomeric component of ginsenoside Rd had no toxicity at the tested range of concentrations. Furthermore, Rd suppressed the inflammatory response of chondrocytes to interleukin (IL)-1β by suppressing the increase in IL-1β, tumor necrosis factor (TNF)-α, IL-6, COX-2, and inducible nitric oxide synthase (iNOS) expression, and retarding IL-1β-induced degradation of chondrocytes by improving cell proliferation characteristics and expression of aggrecan and COL2A1. These protective effects of Rd were associated with ubiquitination of IL-1 receptor accessory protein (IL1RAP), blocking the stimulation of IL-1β to NF-κB. Bioinformatics analysis showed that NEDD4, CBL, CBLB, CBLC, and ITCH most likely target IL1RAP. Rd increased intracellular ITCH level and the amount of ITCH attaching to IL1RAP. Thus, IL1RAP ubiquitination promoted by Rd is likely to occur by up-regulation of ITCH. In summary, Rd inhibited IL-1β-induced inflammation and degradation of intervertebral disc chondrocytes by increasing IL1RAP ubiquitination.
DOI: 10.6084/m9.figshare.9599120.v1
title: Ginsenoside Rd inhibits IL-1β-induced inflammation and degradation of intervertebral disc chondrocytes by increasing IL1RAP ubiquitination

description: Many compounds of ginsenosides show anti-inflammatory properties. However, their anti-inflammatory effects in intervertebral chondrocytes in the presence of inflammatory factors have never been shown. Increased levels of pro-inflammatory cytokines are generally associated with the degradation and death of chondrocytes; therefore, finding an effective and nontoxic substance that attenuates the inflammation is worthwhile. In this study, chondrocytes were isolated from the nucleus pulposus tissues, and the cells were treated with ginsenoside compounds and IL-1β, alone and in combination. Cell viability and death rate were assessed by CCK-8 and flow cytometry methods, respectively. PCR, western blot, and immunoprecipitation assays were performed to determine the mRNA and protein expression, and the interactions between proteins, respectively. Monomeric component of ginsenoside Rd had no toxicity at the tested range of concentrations. Furthermore, Rd suppressed the inflammatory response of chondrocytes to interleukin (IL)-1β by suppressing the increase in IL-1β, tumor necrosis factor (TNF)-α, IL-6, COX-2, and inducible nitric oxide synthase (iNOS) expression, and retarding IL-1β-induced degradation of chondrocytes by improving cell proliferation characteristics and expression of aggrecan and COL2A1. These protective effects of Rd were associated with ubiquitination of IL-1 receptor accessory protein (IL1RAP), blocking the stimulation of IL-1β to NF-κB. Bioinformatics analysis showed that NEDD4, CBL, CBLB, CBLC, and ITCH most likely target IL1RAP. Rd increased intracellular ITCH level and the amount of ITCH attaching to IL1RAP. Thus, IL1RAP ubiquitination promoted by Rd is likely to occur by up-regulation of ITCH. In summary, Rd inhibited IL-1β-induced inflammation and degradation of intervertebral disc chondrocytes by increasing IL1RAP ubiquitination.
DOI: 10.6084/m9.figshare.9599279
title: Palladium Nanoparticles Supported on β-cyclodextrin Functionalised Poly(amido amine)s and their Application in Suzuki-Miyaura Cross-Coupling Reactions

description: Herein, the synthesis, characterization and catalytic application of an organic-inorganic, palladium (Pd)-containing hybrid material, poly(amidoamine)-cyclodextrin (Pd@PAAs-CD), is reported as an efficient catalyst for Suzuki-Miyaura coupling reactions. The structure of Pd@PAAs-CD was confirmed by Fourier transform infrared spectroscopy (FTIR), transmission electron microscopy (TEM), scanning electron microscopy (SEM), inductively-coupled plasma atomic emission spectroscopy (ICP-AES), and 1H nuclear magnetic resonance (NMR) spectroscopy. Furthermore, an efficient protocol has been developed using Pd@PAAs-CD as the catalyst in a Suzuki-Miyaura cross-coupling reaction in an aqueous medium in high yields. By using cyclodextrin (CD) as the mediator grafted onto PAAs, the Pd nanoparticles (NPs) were dispersed and enhanced the catalytic reaction by promoting host-guest interactions with the CD. In addition, the reusability of the Pd@PAAs-CD hybrid material is demonstrated for use in multiple sequential cross-coupling reactions.
DOI: 10.6084/m9.figshare.9599279.v1
title: Palladium Nanoparticles Supported on β-cyclodextrin Functionalised Poly(amido amine)s and their Application in Suzuki-Miyaura Cross-Coupling Reactions

description: Herein, the synthesis, characterization and catalytic application of an organic-inorganic, palladium (Pd)-containing hybrid material, poly(amidoamine)-cyclodextrin (Pd@PAAs-CD), is reported as an efficient catalyst for Suzuki-Miyaura coupling reactions. The structure of Pd@PAAs-CD was confirmed by Fourier transform infrared spectroscopy (FTIR), transmission electron microscopy (TEM), scanning electron microscopy (SEM), inductively-coupled plasma atomic emission spectroscopy (ICP-AES), and 1H nuclear magnetic resonance (NMR) spectroscopy. Furthermore, an efficient protocol has been developed using Pd@PAAs-CD as the catalyst in a Suzuki-Miyaura cross-coupling reaction in an aqueous medium in high yields. By using cyclodextrin (CD) as the mediator grafted onto PAAs, the Pd nanoparticles (NPs) were dispersed and enhanced the catalytic reaction by promoting host-guest interactions with the CD. In addition, the reusability of the Pd@PAAs-CD hybrid material is demonstrated for use in multiple sequential cross-coupling reactions.