cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.8143094.v1
title: Reconstruction ensemble median and 95% range

description: This file contains the the median and 95% range (2.5th and 97.5th percentiles) of the full 7000-member ensemble accross all methods of the PAGES2k Consortium 2019 global mean temperature reconstructions.<br>We recommend working with the full ensemble provided in the other files in this data compilation for a more robust analysis of GMST.The columns in this table are: Year CE, raw instrumental target data, reconstruction ensemble 50th, 2.5th and 97.5th percentiles, 31-year butterworth filtered instrumental target data, 31-year butterworth filtered reconstruction 50th, 2.5th and 97.5th percentilesAll values are °C wrt 1961-1990 over the May-April annual average.
DOI: 10.6084/m9.figshare.8143094.v2
title: Reconstruction ensemble median and 95% range

description: This file contains the the median and 95% range (2.5th and 97.5th percentiles) of the full 7000-member ensemble accross all methods of the PAGES2k Consortium 2019 global mean temperature reconstructions.<br>We strongly recommend working with the full ensemble provided in the other files in this data compilation for a more robust analysis of GMST.The columns in this table are: Year CE, raw instrumental target data, reconstruction ensemble 50th, 2.5th and 97.5th percentiles, 31-year butterworth filtered instrumental target data, 31-year butterworth filtered reconstruction 50th, 2.5th and 97.5th percentilesAll values are °C wrt 1961-1990 over the May-April annual average.
DOI: 10.6084/m9.figshare.8143073
title: Raw Data for tree aging.zip

description: This is the raw data of tree aging's anatomical structure and ultrastructure.
DOI: 10.6084/m9.figshare.8143073.v1
title: Raw Data for tree aging.zip

description: This is the raw data of tree aging's anatomical structure and ultrastructure.
DOI: 10.6084/m9.figshare.8143070
title: Table S1 from Regulation of gene expression in trypanosomatids: living with polycistronic transcription

description: This table lists RNA-binding proteins and proteins that are implicated in mRNA processing, export and degradation, with references. A detailed legend is on the first sheet.
DOI: 10.6084/m9.figshare.8143070.v1
title: Table S1 from Regulation of gene expression in trypanosomatids: living with polycistronic transcription

description: This table lists RNA-binding proteins and proteins that are implicated in mRNA processing, export and degradation, with references. A detailed legend is on the first sheet.
DOI: 10.6084/m9.figshare.12871370
title: Supplementary Material for: Mining Social Media Data to Study the Consequences of Dementia Diagnosis on Caregivers and Relatives

description: <b><i>Introduction:</i></b> Caregivers for people with dementia face a number of challenges such as changing family relationships, social isolation, or financial difficulties. Internet usage and social media are increasingly being recognised as resources to increase support and general public health. <b><i>Objective:</i></b> Using automated analysis, the aim of this study was to explore (i) the age and sex of people who post to the social media forum Reddit about dementia diagnoses, (ii) the affected person and their diagnosis, (iii) which subreddits authors are posting to, (iv) the types of messages posted, and (v) the content of these posts. <b><i>Methods:</i></b> We analysed Reddit posts concerning dementia diagnoses and used a previously developed text analysis pipeline to determine attributes of the posts and their authors. The posts were further examined through manual annotation of the diagnosis provided and the person affected. Lastly, we investigated the communities posters engage with and assessed the contents of the posts with an automated topic gathering/clustering technique. <b><i>Results:</i></b> Five hundred and thirty-five Reddit posts were identified as relevant and further processed. The majority of posters in our dataset are females and predominantly close relatives, such as parents and grandparents, are mentioned. The communities frequented and topics gathered reflect not only the person’s diagnosis but also potential outcomes, for example hardships experienced by the caregiver or the requirement for legal support. <b><i>Conclusions:</i></b> This work demonstrates the value of social media data as a resource for in-depth examination of caregivers’ experience after a dementia diagnosis. It is important to study groups actively posting online, both in topic-specific and general communities, as they are most likely to benefit from novel internet-based support systems or interventions.
DOI: 10.6084/m9.figshare.12871370.v1
title: Supplementary Material for: Mining Social Media Data to Study the Consequences of Dementia Diagnosis on Caregivers and Relatives

description: <b><i>Introduction:</i></b> Caregivers for people with dementia face a number of challenges such as changing family relationships, social isolation, or financial difficulties. Internet usage and social media are increasingly being recognised as resources to increase support and general public health. <b><i>Objective:</i></b> Using automated analysis, the aim of this study was to explore (i) the age and sex of people who post to the social media forum Reddit about dementia diagnoses, (ii) the affected person and their diagnosis, (iii) which subreddits authors are posting to, (iv) the types of messages posted, and (v) the content of these posts. <b><i>Methods:</i></b> We analysed Reddit posts concerning dementia diagnoses and used a previously developed text analysis pipeline to determine attributes of the posts and their authors. The posts were further examined through manual annotation of the diagnosis provided and the person affected. Lastly, we investigated the communities posters engage with and assessed the contents of the posts with an automated topic gathering/clustering technique. <b><i>Results:</i></b> Five hundred and thirty-five Reddit posts were identified as relevant and further processed. The majority of posters in our dataset are females and predominantly close relatives, such as parents and grandparents, are mentioned. The communities frequented and topics gathered reflect not only the person’s diagnosis but also potential outcomes, for example hardships experienced by the caregiver or the requirement for legal support. <b><i>Conclusions:</i></b> This work demonstrates the value of social media data as a resource for in-depth examination of caregivers’ experience after a dementia diagnosis. It is important to study groups actively posting online, both in topic-specific and general communities, as they are most likely to benefit from novel internet-based support systems or interventions.
DOI: 10.6084/m9.figshare.8143031
title: Market survey 2019 rawdata

description: Raw data and descriptive statistic data of the market survey performed with the Add-In XLSTAT 2009.1.02 is provided as Excel-file (CSV). The data include file name, sample name, area, calculated N<sub>2</sub>O amounts, test result and statistical values.
DOI: 10.6084/m9.figshare.8143016
title: Validation with Reference samples 2017

description: Raw data of 7 reference samples of 2017 of the validation section are provided as Excel-file (CSV). The data include file name, sample name, certified type of treatment and calculated N2O amounts (single and average values).
DOI: 10.6084/m9.figshare.8142992
title: Fig03 brining experiment rawdata.csv

description: Raw data and descriptive statistic data (univariate diagram) of figure 03 performed with the Add-In XLSTAT 2009.1.02 is provided as CSV. The data include file name, sample name, type of treatment, area, calculated N2O amounts and statistical values.
DOI: 10.6084/m9.figshare.8142932
title: Environmental data for LMO site

description: This datafile contains environmental data for the Linnaeus Microbial Observatory site.
DOI: 10.6084/m9.figshare.8142926
title: Mast cell counts and degranulation at sciatic nerve and DRG

description: Mast cells are counted at the sciatic nerve and DRG and presented as cells per ROI. Mcpt1 particles represent the extent of degranulation and are counted at the sciatic nerve and DRG--and are presented as Mcpt1 particles per ROI.
DOI: 10.6084/m9.figshare.8142881
title: Additional file 2: of Are non-constant rates and non-proportional treatment effects accounted for in the design and analysis of randomised controlled trials? A review of current practice

description: Determination of the characteristics of the sixty-six randomised clinical trials in this review. Dataset containing the final determinations of trial characteristics. (XLS 63 kb)
DOI: 10.6084/m9.figshare.8142881.v1
title: Additional file 2: of Are non-constant rates and non-proportional treatment effects accounted for in the design and analysis of randomised controlled trials? A review of current practice

description: Determination of the characteristics of the sixty-six randomised clinical trials in this review. Dataset containing the final determinations of trial characteristics. (XLS 63 kb)
DOI: 10.6084/m9.figshare.8142875
title: Additional file 2: of Life and expectations post-kidney transplant: a qualitative analysis of patient responses

description: Open-Ended Responses. This file includes the participant responses to the three open-ended questions. (XLSX 45 kb)
DOI: 10.6084/m9.figshare.8142875.v1
title: Additional file 2: of Life and expectations post-kidney transplant: a qualitative analysis of patient responses

description: Open-Ended Responses. This file includes the participant responses to the three open-ended questions. (XLSX 45 kb)
DOI: 10.6084/m9.figshare.8142833
title: Additional file 6: of Paired whole exome and transcriptome analyses for the Immunogenomic changes during concurrent chemoradiotherapy in esophageal squamous cell carcinoma

description: Table S6. Differentially expressed genes between of pre-concurrent chemoradiation therapy (CCRT) and post-CCRT in no pCR and pCR patients (XLSX 3700 kb)
DOI: 10.6084/m9.figshare.8142833.v1
title: Additional file 6: of Paired whole exome and transcriptome analyses for the Immunogenomic changes during concurrent chemoradiotherapy in esophageal squamous cell carcinoma

description: Table S6. Differentially expressed genes between of pre-concurrent chemoradiation therapy (CCRT) and post-CCRT in no pCR and pCR patients (XLSX 3700 kb)
DOI: 10.6084/m9.figshare.8142830
title: Additional file 2: of Glaucoma-causing ADAMTS17 mutations are also reproducibly associated with height in two domestic dog breeds: selection for short stature may have contributed to increased prevalence of glaucoma

description: Raw data from SP measurements. (XLSX 18 kb)
DOI: 10.6084/m9.figshare.8142830.v1
title: Additional file 2: of Glaucoma-causing ADAMTS17 mutations are also reproducibly associated with height in two domestic dog breeds: selection for short stature may have contributed to increased prevalence of glaucoma

description: Raw data from SP measurements. (XLSX 18 kb)
DOI: 10.6084/m9.figshare.8142827
title: Additional file 5: of Paired whole exome and transcriptome analyses for the Immunogenomic changes during concurrent chemoradiotherapy in esophageal squamous cell carcinoma

description: Table S5. The difference between groups for relative fractions of major immune cell types compared by surgical pathology. The significance was measured by t-test between two sample groups. (XLSX 12 kb)
DOI: 10.6084/m9.figshare.8142827.v1
title: Additional file 5: of Paired whole exome and transcriptome analyses for the Immunogenomic changes during concurrent chemoradiotherapy in esophageal squamous cell carcinoma

description: Table S5. The difference between groups for relative fractions of major immune cell types compared by surgical pathology. The significance was measured by t-test between two sample groups. (XLSX 12 kb)
DOI: 10.6084/m9.figshare.8142821
title: Additional file 1: of Glaucoma-causing ADAMTS17 mutations are also reproducibly associated with height in two domestic dog breeds: selection for short stature may have contributed to increased prevalence of glaucoma

description: Raw data from PBGV measurements. (XLSX 47 kb)
DOI: 10.6084/m9.figshare.8142821.v1
title: Additional file 1: of Glaucoma-causing ADAMTS17 mutations are also reproducibly associated with height in two domestic dog breeds: selection for short stature may have contributed to increased prevalence of glaucoma

description: Raw data from PBGV measurements. (XLSX 47 kb)
DOI: 10.6084/m9.figshare.8142818
title: Additional file 4: of Paired whole exome and transcriptome analyses for the Immunogenomic changes during concurrent chemoradiotherapy in esophageal squamous cell carcinoma

description: Table S4. Differentially expressed genes between pre-concurrent chemoradiation therapy (CCRT) and post-CCRT (XLSX 1920 kb)
DOI: 10.6084/m9.figshare.8142818.v1
title: Additional file 4: of Paired whole exome and transcriptome analyses for the Immunogenomic changes during concurrent chemoradiotherapy in esophageal squamous cell carcinoma

description: Table S4. Differentially expressed genes between pre-concurrent chemoradiation therapy (CCRT) and post-CCRT (XLSX 1920 kb)
DOI: 10.6084/m9.figshare.8142815
title: Additional file 3: of Paired whole exome and transcriptome analyses for the Immunogenomic changes during concurrent chemoradiotherapy in esophageal squamous cell carcinoma

description: Table S3. The difference between groups for relative fractions of major immune cell types compared by increase in immune score calculated by ESTIMATE. The significance was measured by a t-test between two sample groups. (XLSX 13 kb)
DOI: 10.6084/m9.figshare.8142815.v1
title: Additional file 3: of Paired whole exome and transcriptome analyses for the Immunogenomic changes during concurrent chemoradiotherapy in esophageal squamous cell carcinoma

description: Table S3. The difference between groups for relative fractions of major immune cell types compared by increase in immune score calculated by ESTIMATE. The significance was measured by a t-test between two sample groups. (XLSX 13 kb)
DOI: 10.6084/m9.figshare.8142806
title: Additional file 2: of Paired whole exome and transcriptome analyses for the Immunogenomic changes during concurrent chemoradiotherapy in esophageal squamous cell carcinoma

description: Table S2. Samples available for the Multiplex IHC (XLSX 11 kb)
DOI: 10.6084/m9.figshare.8142806.v1
title: Additional file 2: of Paired whole exome and transcriptome analyses for the Immunogenomic changes during concurrent chemoradiotherapy in esophageal squamous cell carcinoma

description: Table S2. Samples available for the Multiplex IHC (XLSX 11 kb)
DOI: 10.6084/m9.figshare.8142794
title: Additional file 1: of Paired whole exome and transcriptome analyses for the Immunogenomic changes during concurrent chemoradiotherapy in esophageal squamous cell carcinoma

description: Table S1. Clinical information of study population (XLS 2133 kb)
DOI: 10.6084/m9.figshare.8142794.v1
title: Additional file 1: of Paired whole exome and transcriptome analyses for the Immunogenomic changes during concurrent chemoradiotherapy in esophageal squamous cell carcinoma

description: Table S1. Clinical information of study population (XLS 2133 kb)
DOI: 10.6084/m9.figshare.8142758
title: MOESM1 of A reduction in ecological niche for Trypanosoma cruzi-infected triatomine bugs

description: Additional file 1: Table S1. Geographical data for Triatoma pallidipennnis. Table S2. Geographical data for Triatoma longipennis. Table S3. Geographical data for T. mazzottii. Table S4. Geographical data for Triatoma phyllosoma. Table S5. Geographical data for Triatoma picturata. Table S6. Geographical data for Triatoma dimidiata. Table S7. Geographical data for Triatoma barberi. Table S8. References of geographical data for all species.
DOI: 10.6084/m9.figshare.8142758.v1
title: MOESM1 of A reduction in ecological niche for Trypanosoma cruzi-infected triatomine bugs

description: Additional file 1: Table S1. Geographical data for Triatoma pallidipennnis. Table S2. Geographical data for Triatoma longipennis. Table S3. Geographical data for T. mazzottii. Table S4. Geographical data for Triatoma phyllosoma. Table S5. Geographical data for Triatoma picturata. Table S6. Geographical data for Triatoma dimidiata. Table S7. Geographical data for Triatoma barberi. Table S8. References of geographical data for all species.
DOI: 10.6084/m9.figshare.8142752
title: MOESM6 of Reduction of a nymphal instar in a dampwood termite: heterochronic shift in the caste differentiation pathways

description: Additional file 6. Table S4. Primer sequences for real time quantitative RT-PCR.
DOI: 10.6084/m9.figshare.8142752.v1
title: MOESM6 of Reduction of a nymphal instar in a dampwood termite: heterochronic shift in the caste differentiation pathways

description: Additional file 6. Table S4. Primer sequences for real time quantitative RT-PCR.
DOI: 10.6084/m9.figshare.8142746
title: MOESM5 of Reduction of a nymphal instar in a dampwood termite: heterochronic shift in the caste differentiation pathways

description: Additional file 5. Table S3. Candidate genes focused in this study.
DOI: 10.6084/m9.figshare.8142746.v1
title: MOESM5 of Reduction of a nymphal instar in a dampwood termite: heterochronic shift in the caste differentiation pathways

description: Additional file 5. Table S3. Candidate genes focused in this study.
DOI: 10.6084/m9.figshare.8142740
title: MOESM4 of Reduction of a nymphal instar in a dampwood termite: heterochronic shift in the caste differentiation pathways

description: Additional file 4. Table S2. Statistical results of the three models hypothesizing the growth stages in Zootermopsis nevadensis to match those in Hodotermopsis sjostedti. The asterisks indicate the statistical significances of the respective parameters tested by the Wald test (n = 45; P &lt; 0.05). The hypothetical growth stages in the best model independent from species differences are shown as bold. PE, workers; NE, early nymphal stage; NL, late nymphal stage; A, alate.
DOI: 10.6084/m9.figshare.8142740.v1
title: MOESM4 of Reduction of a nymphal instar in a dampwood termite: heterochronic shift in the caste differentiation pathways

description: Additional file 4. Table S2. Statistical results of the three models hypothesizing the growth stages in Zootermopsis nevadensis to match those in Hodotermopsis sjostedti. The asterisks indicate the statistical significances of the respective parameters tested by the Wald test (n = 45; P &lt; 0.05). The hypothetical growth stages in the best model independent from species differences are shown as bold. PE, workers; NE, early nymphal stage; NL, late nymphal stage; A, alate.
DOI: 10.6084/m9.figshare.8142728
title: MOESM3 of Reduction of a nymphal instar in a dampwood termite: heterochronic shift in the caste differentiation pathways

description: Additional file 2. Table S1. Cumulative proportions and principal component loadings in the principal component analysis targeting the gene expression levels in Zootermopsis nevadensis and Hodotermopsis sjostedti. Four principal components were selected in accordance with the Kaiserâ s rule. Bold letters indicate the value higher than 0.4.
DOI: 10.6084/m9.figshare.8142728.v1
title: MOESM3 of Reduction of a nymphal instar in a dampwood termite: heterochronic shift in the caste differentiation pathways

description: Additional file 2. Table S1. Cumulative proportions and principal component loadings in the principal component analysis targeting the gene expression levels in Zootermopsis nevadensis and Hodotermopsis sjostedti. Four principal components were selected in accordance with the Kaiserâ s rule. Bold letters indicate the value higher than 0.4.
DOI: 10.6084/m9.figshare.11567388.v1
title: Modulation of adiponectin receptors AdipoR1 and AdipoR2 by phage display-derived peptides in <i>in vitro</i> and <i>in vivo</i> models

description: Type 2 diabetes (T2D) is often linked to metabolic syndrome, which assembles various risk factors related to obesity. Plasma levels of adiponectin are decreased in T2D and obese subjects. Aiming to develop a peptide able to bind adiponectin receptors and modulate their signalling pathways, a 12-amino acid sequence homologous in AdipoR1/R2 has been targeted by phage display with a linear 12-mer peptide library. The selected peptide P17 recognises AdipoR1/R2 expressed by skeletal muscle, liver and pancreatic islets. In HepaRG and C2C12 cells, P17 induced the activation of AMPK (AMPKα-pT172) and the expression of succinate dehydrogenase and glucokinase; no cytotoxic effects were observed on HepaRG cells. In db/db mice, P17 promoted body weight and glycaemia stabilisation, decreased plasma triglycerides to the range of healthy mice and increased adiponectin (in high fat-fed mice) and insulin (in chow-fed mice) levels. It restored to the range of healthy mice the tissue levels and subcellular distribution of AdipoR1/R2, AMPKα-pT172 and PPARα-pS12. In liver, P17 reduced steatosis and apoptosis. The docking of P17 to AdipoR is reminiscent of the binding mechanism of adiponectin. To conclude, we have developed an AdipoR1/AdipoR2-targeted peptide that modulates adiponectin signalling pathways and has therapeutic relevance for T2D and obesity associated pathologies.
DOI: 10.6084/m9.figshare.11567388
title: Modulation of adiponectin receptors AdipoR1 and AdipoR2 by phage display-derived peptides in <i>in vitro</i> and <i>in vivo</i> models

description: Type 2 diabetes (T2D) is often linked to metabolic syndrome, which assembles various risk factors related to obesity. Plasma levels of adiponectin are decreased in T2D and obese subjects. Aiming to develop a peptide able to bind adiponectin receptors and modulate their signalling pathways, a 12-amino acid sequence homologous in AdipoR1/R2 has been targeted by phage display with a linear 12-mer peptide library. The selected peptide P17 recognises AdipoR1/R2 expressed by skeletal muscle, liver and pancreatic islets. In HepaRG and C2C12 cells, P17 induced the activation of AMPK (AMPKα-pT172) and the expression of succinate dehydrogenase and glucokinase; no cytotoxic effects were observed on HepaRG cells. In db/db mice, P17 promoted body weight and glycaemia stabilisation, decreased plasma triglycerides to the range of healthy mice and increased adiponectin (in high fat-fed mice) and insulin (in chow-fed mice) levels. It restored to the range of healthy mice the tissue levels and subcellular distribution of AdipoR1/R2, AMPKα-pT172 and PPARα-pS12. In liver, P17 reduced steatosis and apoptosis. The docking of P17 to AdipoR is reminiscent of the binding mechanism of adiponectin. To conclude, we have developed an AdipoR1/AdipoR2-targeted peptide that modulates adiponectin signalling pathways and has therapeutic relevance for T2D and obesity associated pathologies.
DOI: 10.6084/m9.figshare.8142653
title: Additional file 2: of Isolation of novel gut bifidobacteria using a combination of metagenomic and cultivation approaches

description: Table S1. Metagenomic sequence data. Table S2. Predicted glycobiome of novel species. Table S3. ITS sequences of the 15 bifidobacterial isolates. Table S4. General genetic features. Table S5. Average Nucleotide Identity between bifidobacterial taxa. (XLSX 78 kb)
DOI: 10.6084/m9.figshare.8142653.v1
title: Additional file 2: of Isolation of novel gut bifidobacteria using a combination of metagenomic and cultivation approaches

description: Table S1. Metagenomic sequence data. Table S2. Predicted glycobiome of novel species. Table S3. ITS sequences of the 15 bifidobacterial isolates. Table S4. General genetic features. Table S5. Average Nucleotide Identity between bifidobacterial taxa. (XLSX 78 kb)
DOI: 10.6084/m9.figshare.8142620
title: Additional file 4: of Addressing confounding artifacts in reconstruction of gene co-expression networks

description: Tutorial vignette to apply PC correction prior to network reconstruction in an example dataset. (HTML 726 kb)