cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.17632/hnrrpyyrvz
title: Restoration of Cellular Homeostasis by Vx-445 Under ER Stress Conditions: Insights from Biochemical and Proteomic Assays _ Expression Proteomics_2

description: Endoplasmic reticulum (ER) stress is a patho-physiological condition that plays a central role in the development of various human diseases. Multiple intracellular and extracellular factors can impair protein folding, leading to protein misfolding diseases (PMDs). Cystic fibrosis (CF) is a notable example, whose pharmacological management relies on combinations of modulators—such as the corrector Vx-445, that targets the defect in the cystic fibrosis transmembrane conductance regulator (CFTR). In vitro binding assays so far are unable to demonstrate a direct interaction between the corrector and CFTR in the cellular environment, leaving its precise mechanism of action unresolved. Thus, this study aims to investigate the role of Vx-445 in neuronal cells, following the induction of ER stress with Thapsigargin, a specific inhibitor of the sarcoplasmic/endoplasmic reticulum Ca2+-ATPase (SERCA), by a multi-disciplinary approach involving biochemical assays, label-free and functional proteomics. Our findings revealed that Vx-445 may participate in the regulation of oxidative stress, as evidenced by its ability to reduce intracellular ROS levels. Additionally, it influences calcium homeostasis, as it was able to restore this system to its basal state and it seems to play a role in modulating apoptosis, as indicated by its capacity to lower cytochrome c release. These results were supported by both expression proteomics and DARTS (Drug Affinity Responsive Target Stability) analyses, aimed at identifying the main cellular pathways restored by Vx-445 and potential protein interaction partners. Overall, the findings could improve our understanding of the cellular targets of CFTR modulators and offer new opportunities for drug repurposing strategies.
This dataset comprises Thapsigargin raw data of the expression proteomics experiments.
DOI: 10.15468/dl.3pspte
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "HasGeospatialIssue is false",
 "HasCoordinate is true",
 "OccurrenceStatus is Present",
 "BasisOfRecord is one of (Human Observation, Machine Observation, Occurrence evidence, Observation)",
 "TaxonKey is one of (Falco rupicoloides)",
 "Country is one of (American Samoa, Australia, Christmas Island, Cocos (Keeling) Islands, Cook Islands, Fiji, French Polynesia, Guam, Heard Island and McDonald Islands, Kiribati, Marshall Islands, Micronesia (Federated States of), Nauru, New Caledonia, New Zealand, Niue, Norfolk Island, Northern Mariana Islands, Palau, Papua New Guinea, Pitcairn, Samoa, Solomon Islands, Tokelau, Tonga, Tuvalu, United States Minor Outlying Islands, Vanuatu, Wallis and Futuna)"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0028963-250717081556266/datasets/export for details.
DOI: 10.17632/hnrrpyyrvz.1
title: Restoration of Cellular Homeostasis by Vx-445 Under ER Stress Conditions: Insights from Biochemical and Proteomic Assays _ Expression Proteomics_2

description: Endoplasmic reticulum (ER) stress is a patho-physiological condition that plays a central role in the development of various human diseases. Multiple intracellular and extracellular factors can impair protein folding, leading to protein misfolding diseases (PMDs). Cystic fibrosis (CF) is a notable example, whose pharmacological management relies on combinations of modulators—such as the corrector Vx-445, that targets the defect in the cystic fibrosis transmembrane conductance regulator (CFTR). In vitro binding assays so far are unable to demonstrate a direct interaction between the corrector and CFTR in the cellular environment, leaving its precise mechanism of action unresolved. Thus, this study aims to investigate the role of Vx-445 in neuronal cells, following the induction of ER stress with Thapsigargin, a specific inhibitor of the sarcoplasmic/endoplasmic reticulum Ca2+-ATPase (SERCA), by a multi-disciplinary approach involving biochemical assays, label-free and functional proteomics. Our findings revealed that Vx-445 may participate in the regulation of oxidative stress, as evidenced by its ability to reduce intracellular ROS levels. Additionally, it influences calcium homeostasis, as it was able to restore this system to its basal state and it seems to play a role in modulating apoptosis, as indicated by its capacity to lower cytochrome c release. These results were supported by both expression proteomics and DARTS (Drug Affinity Responsive Target Stability) analyses, aimed at identifying the main cellular pathways restored by Vx-445 and potential protein interaction partners. Overall, the findings could improve our understanding of the cellular targets of CFTR modulators and offer new opportunities for drug repurposing strategies.
This dataset comprises Thapsigargin raw data of the expression proteomics experiments.
DOI: 10.17632/p5wy5bpkr2
title: Restoration of Cellular Homeostasis by Vx-445 Under ER Stress Conditions: Insights from Biochemical and Proteomic Assays _ Expression Proteomics_3

description: Endoplasmic reticulum (ER) stress is a patho-physiological condition that plays a central role in the development of various human diseases. Multiple intracellular and extracellular factors can impair protein folding, leading to protein misfolding diseases (PMDs). Cystic fibrosis (CF) is a notable example, whose pharmacological management relies on combinations of modulators—such as the corrector Vx-445, that targets the defect in the cystic fibrosis transmembrane conductance regulator (CFTR). In vitro binding assays so far are unable to demonstrate a direct interaction between the corrector and CFTR in the cellular environment, leaving its precise mechanism of action unresolved. Thus, this study aims to investigate the role of Vx-445 in neuronal cells, following the induction of ER stress with Thapsigargin, a specific inhibitor of the sarcoplasmic/endoplasmic reticulum Ca2+-ATPase (SERCA), by a multi-disciplinary approach involving biochemical assays, label-free and functional proteomics. Our findings revealed that Vx-445 may participate in the regulation of oxidative stress, as evidenced by its ability to reduce intracellular ROS levels. Additionally, it influences calcium homeostasis, as it was able to restore this system to its basal state and it seems to play a role in modulating apoptosis, as indicated by its capacity to lower cytochrome c release. These results were supported by both expression proteomics and DARTS (Drug Affinity Responsive Target Stability) analyses, aimed at identifying the main cellular pathways restored by Vx-445 and potential protein interaction partners. Overall, the findings could improve our understanding of the cellular targets of CFTR modulators and offer new opportunities for drug repurposing strategies.
This dataset comprises Thapsigargin/Vx-445 raw data of the expression proteomics experiments.
DOI: 10.17632/p5wy5bpkr2.1
title: Restoration of Cellular Homeostasis by Vx-445 Under ER Stress Conditions: Insights from Biochemical and Proteomic Assays _ Expression Proteomics_3

description: Endoplasmic reticulum (ER) stress is a patho-physiological condition that plays a central role in the development of various human diseases. Multiple intracellular and extracellular factors can impair protein folding, leading to protein misfolding diseases (PMDs). Cystic fibrosis (CF) is a notable example, whose pharmacological management relies on combinations of modulators—such as the corrector Vx-445, that targets the defect in the cystic fibrosis transmembrane conductance regulator (CFTR). In vitro binding assays so far are unable to demonstrate a direct interaction between the corrector and CFTR in the cellular environment, leaving its precise mechanism of action unresolved. Thus, this study aims to investigate the role of Vx-445 in neuronal cells, following the induction of ER stress with Thapsigargin, a specific inhibitor of the sarcoplasmic/endoplasmic reticulum Ca2+-ATPase (SERCA), by a multi-disciplinary approach involving biochemical assays, label-free and functional proteomics. Our findings revealed that Vx-445 may participate in the regulation of oxidative stress, as evidenced by its ability to reduce intracellular ROS levels. Additionally, it influences calcium homeostasis, as it was able to restore this system to its basal state and it seems to play a role in modulating apoptosis, as indicated by its capacity to lower cytochrome c release. These results were supported by both expression proteomics and DARTS (Drug Affinity Responsive Target Stability) analyses, aimed at identifying the main cellular pathways restored by Vx-445 and potential protein interaction partners. Overall, the findings could improve our understanding of the cellular targets of CFTR modulators and offer new opportunities for drug repurposing strategies.
This dataset comprises Thapsigargin/Vx-445 raw data of the expression proteomics experiments.
DOI: 10.14473/csda/crurbi
title: Květen 1991 - Kontinuální měsíční výzkum IVVM

description: Kontinuální měsíční výzkum provedl výzkumný tým Institutu pro výzkum veřejného mínění v rámci pravidelného měsíčního výzkumného projektu. Jsou při něm zjišťovány postoje a názory občanů.
description: Kontinuální měsíční výzkum IVVM
DOI: 10.25345/c50p0x398
title: MassIVE MSV000098594 - 211104_Labeled_MTX_monocultures_24_48H
title: Monocultures were incubated in vitro with labeled methotrexate and profiled for metabolism
DOI: 10.17632/8ng8tb49yn.1
title: Embedding Tensor for Two-Dimensional Carbon Allotropes

description: Data set for paper "Graph Embedding Tensor: Unifying Topological Description, Symmetry Detection, and Structure Generation for Two-dimensional Carbon Allotropes". Data provided here are examples of embedding tensors for all structures obtained with up to 14 atoms per unit cell in 2D carbon crystals with threefold atomic coordination.
DOI: 10.15468/dl.prj6m2
title: Occurrence Download

description: A dataset containing 41 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Cotula coronopifolia",
 "Country is Italy",
 "HasCoordinate is true"
 ]
}

 The dataset includes 41 records from 5 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0028968-250717081556266/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.14473/csda/sfi6fw
title: Březen 1991 IV. - Kontinuální měsíční výzkum IVVM

description: Kontinuální měsíční výzkum provedl výzkumný tým Institutu pro výzkum veřejného mínění v rámci pravidelného měsíčního výzkumného projektu. Jsou při něm zjišťovány postoje a názory občanů.
description: Kontinuální měsíční výzkum IVVM
DOI: 10.17632/pwkvwht63j
title: Paired-field evaluation of a saturated buffer reveals significant water-quality benefit through upstream weir management

description: This is the dataset for the paper entitled "Paired-field evaluation of a saturated buffer reveals significant water-quality benefit through upstream weir management"
DOI: 10.17632/pwkvwht63j.2
title: Paired-field evaluation of a saturated buffer reveals significant water-quality benefit through upstream weir management

description: This is the dataset for the paper entitled "Paired-field evaluation of a saturated buffer reveals significant water-quality benefit through upstream weir management"
DOI: 10.15468/dl.bytqbb
title: Occurrence Download

description: A dataset containing 8306 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Cotula coronopifolia",
 "Country is Netherlands",
 "HasCoordinate is true"
 ]
}

 The dataset includes 8306 records from 13 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0028969-250717081556266/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.17632/7ztmxgdx68.2
title: Data for Sensitivity Analysis of the Human Development Index: Implications for Methodological Refinements and Policy Strategies

description: Dataset used in the paper Sensitivity Analysis of the Human Development Index: Implications for Methodological Refinements and Policy Strategies. This dataset is a pivoted to wide version from the dataset HDR25_Composite_indices_complete_time_series that can be found in https://hdr.undp.org/sites/default/files/2025_HDR/HDR25_Composite_indices_complete_time_series.csv
Script to reproduce the analysis and visualizations is also included
DOI: 10.14473/csda/l7xa8a
title: Březen 1991 III. - Kontinuální měsíční výzkum IVVM

description: Kontinuální měsíční výzkum provedl výzkumný tým Institutu pro výzkum veřejného mínění v rámci pravidelného měsíčního výzkumného projektu. Jsou při něm zjišťovány postoje a názory občanů.
description: Kontinuální měsíční výzkum IVVM
DOI: 10.15468/dl.j69wg8
title: Occurrence Download

description: A dataset containing 1715 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Geometry POLYGON((-3.55345 43.12445,-3.5332 43.11939,-3.5238 43.11732,-3.51586 43.11516,-3.48618 43.10648,-3.45063 43.08983,-3.45742 43.1142,-3.53151 43.14217,-3.55501 43.14792,-3.57623 43.15584,-3.58408 43.15722,-3.59142 43.15315,-3.59148 43.14888,-3.59252 43.14241,-3.59906 43.13101,-3.6061 43.13156,-3.61573 43.13109,-3.63429 43.12874,-3.64556 43.12803,-3.75658 43.11125,-3.76685 43.12879,-3.78702 43.14708,-3.80546 43.17485,-3.81982 43.17096,-3.80224 43.146,-3.79889 43.13616,-3.78704 43.12198,-3.77776 43.10598,-3.77005 43.09779,-3.75367 43.09538,-3.60032 43.10976,-3.59133 43.11937,-3.58946 43.12351,-3.58476 43.13111,-3.58241 43.13617,-3.58078 43.13889,-3.56968 43.12869,-3.55345 43.12445))",
 "IucnRedListCategory is one of (EN, VU, NT, LC)",
 "OccurrenceStatus is Present"
 ]
}

 The dataset includes 1715 records from 39 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0028970-250717081556266/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.bf2aws
title: Occurrence Download

description: A dataset containing 1249 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Cotula coronopifolia",
 "Country is Portugal",
 "HasCoordinate is true"
 ]
}

 The dataset includes 1249 records from 25 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0028971-250717081556266/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.17632/cpm6ryzn7c
title: Silenced at Home: Epistemic Injustice and the Symbolic Power of the Patriarchal Family in Child Sexual Abuse

description: The research hypothesis of this article posits that within the patriarchal family structure, there exists a mechanism of symbolic power that produces epistemic injustice, systematically silencing and disregarding the voices of child victims of sexual abuse. The data used stem from a critical analysis of academic literature indexed in the Scopus database, focusing on studies addressing child sexual abuse in the context of patriarchal families. Data collection involved searching for relevant studies and carefully analyzing the texts using ideas from Pierre Bourdieu about symbolic power, Miranda Fricker about epistemic injustice, and Boaventura de Sousa Santos about epistemicide. Key findings reveal that moral norms emphasizing obedience, sacrifice, and family honor are symbolically employed to justify and conceal sexual abuse, resulting in epistemic silencing that hampers victim recognition and recovery. The analysis of this data highlights the need for a change in child protection systems to recognize victims as valid sources of information and to confront the patriarchal systems that continue cycles of violence and silence. This research provides a foundation for further studies on the relationship between symbolic power and epistemic injustice in child sexual abuse within patriarchal families and supports policy and social change efforts aimed at enhancing child protection.
DOI: 10.14473/csda/ogj0et
title: Březen 1991 II. - Kontinuální měsíční výzkum IVVM

description: Kontinuální měsíční výzkum provedl výzkumný tým Institutu pro výzkum veřejného mínění v rámci pravidelného měsíčního výzkumného projektu. Jsou při něm zjišťovány postoje a názory občanů.
description: Kontinuální měsíční výzkum IVVM
DOI: 10.17632/cpm6ryzn7c.2
title: Silenced at Home: Epistemic Injustice and the Symbolic Power of the Patriarchal Family in Child Sexual Abuse

description: The research hypothesis of this article posits that within the patriarchal family structure, there exists a mechanism of symbolic power that produces epistemic injustice, systematically silencing and disregarding the voices of child victims of sexual abuse. The data used stem from a critical analysis of academic literature indexed in the Scopus database, focusing on studies addressing child sexual abuse in the context of patriarchal families. Data collection involved searching for relevant studies and carefully analyzing the texts using ideas from Pierre Bourdieu about symbolic power, Miranda Fricker about epistemic injustice, and Boaventura de Sousa Santos about epistemicide. Key findings reveal that moral norms emphasizing obedience, sacrifice, and family honor are symbolically employed to justify and conceal sexual abuse, resulting in epistemic silencing that hampers victim recognition and recovery. The analysis of this data highlights the need for a change in child protection systems to recognize victims as valid sources of information and to confront the patriarchal systems that continue cycles of violence and silence. This research provides a foundation for further studies on the relationship between symbolic power and epistemic injustice in child sexual abuse within patriarchal families and supports policy and social change efforts aimed at enhancing child protection.
DOI: 10.6084/m9.figshare.19596355
title: NYT-KG

description: Relation extraction dataset with its knowledge graph.
DOI: 10.6084/m9.figshare.19596355.v2
title: NYT-KG

description: Relation extraction dataset with its knowledge graph.
DOI: 10.6084/m9.figshare.19596355.v1
title: NYT10m

description: Relation extraction dataset with its knowledge graph.
DOI: 10.15468/dl.57p5jf
title: Occurrence Download

description: A dataset containing 6238 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Chondrilla juncea",
 "Country is United States of America",
 "HasCoordinate is true"
 ]
}

 The dataset includes 6238 records from 65 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0028975-250717081556266/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.v7jduw
title: Occurrence Download

description: A dataset containing 1557 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Glycyrrhiza uralensis"
 ]
}

 The dataset includes 1557 records from 73 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0028974-250717081556266/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.h69gmj
title: Occurrence Download

description: A dataset containing 115 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Barbodes banksi"
 ]
}

 The dataset includes 115 records from 6 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0028972-250717081556266/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.17632/4hw52rnjrj
title: Metabolomics data relating to DiFraia et al "Altered translation elongation contributes to key hallmarks of aging in killifish brain"

description: This dataset contains targeted metabolomics data of aging fish brain samples. Data acquired on an Agilent 1290 Infinity II UPLC coupled to an Agilent 6470 triple quadrupole mass spectrometer. The analytical method was based on that developed by Mülleder et al. (2016) "Functional Metabolomics Describes the Yeast Biosynthetic Regulome". Cell. 167(2):553-565.e12. doi:10.1016/j.cell.2016.09.007.
DOI: 10.17632/4hw52rnjrj.1
title: Metabolomics data relating to DiFraia et al "Altered translation elongation contributes to key hallmarks of aging in killifish brain"

description: This dataset contains targeted metabolomics data of aging fish brain samples. Data acquired on an Agilent 1290 Infinity II UPLC coupled to an Agilent 6470 triple quadrupole mass spectrometer. The analytical method was based on that developed by Mülleder et al. (2016) "Functional Metabolomics Describes the Yeast Biosynthetic Regulome". Cell. 167(2):553-565.e12. doi:10.1016/j.cell.2016.09.007.
DOI: 10.17632/mkkn5shxbw
title: Survey data on mobile learning ability of vocational college students

description: Survey data on mobile learning ability of vocational college students
DOI: 10.17632/mkkn5shxbw.1
title: Survey data on mobile learning ability of vocational college students

description: Survey data on mobile learning ability of vocational college students
DOI: 10.15468/dl.2622sv
title: Occurrence Download

description: A dataset containing 10 species occurrences available in GBIF matching the query:
{
 "DatasetKey" : [
 "is Registros de mamíferos en cámaras trampa Botín 2024 - Grupo HAME"
 ]
}

 The dataset includes 10 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0028976-250717081556266/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.25444/nhlbi.29425343
title: Data Supporting Long-term mitapivat treatment in SCD

description: Excel files/spreadsheets with demographics, clinical laboratory results, exploratory data (P50/T50/2,3-DPG/ATP), Patient quality of life questionnaire data.
DOI: 10.25444/nhlbi.29425343.v1
title: Data Supporting Long-term mitapivat treatment in SCD

description: Excel files/spreadsheets with demographics, clinical laboratory results, exploratory data (P50/T50/2,3-DPG/ATP), Patient quality of life questionnaire data.
DOI: 10.15468/dl.qrs745
title: Occurrence Download

description: A dataset containing 2323 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Dactylorhiza romana"
 ]
}

 The dataset includes 2323 records from 109 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0028978-250717081556266/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.