cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.14825023.v1
title: An application of nuclear magnetic resonance spectroscopy to study faecal canine metabolome

description: Metabolomics provides a description of the phenotype of an organism and complementary biochemical information to genomics and proteomics. The purpose of this research was to depict the metabolite profile of faecal samples from dogs fed three different diets through NMR spectroscopy analysis. Samples were collected from 14 dogs fed a commercial extruded diet, 18 dogs fed a homemade diet and 16 dogs fed a raw meat-based diet. The average BCS for all dogs was 4–5 and the average Faecal Score was 2–3. Only healthy animals were considered, as assessed from the clinical evaluation of the veterinarians. Faecal samples were prepared using phosphate buffer (pH 7.1) combined with deuterated water and analysed with NMR spectroscopy using a Bruker Avance III HD 400 MHz spectrometer. Principal component analysis of the spectra signals demonstrated clustering of dogs according to diet, with 57.8% of the variance explained by the first three components. Targeted metabolome analysis was also performed on 56 metabolites of interest, selected from a database of 558 metabolites. Our data suggest that metabolome analysis using NMR is a promising approach to describe the phenotypic variation that occurs among dogs fed different diets.The metabolomic approach is becoming always more important in the evaluation of the functional responses of animals to dietary intervention.NMR-metabolomics has emerged as a non-destructive technique that allows a simpler data interpretation compared to other techniques.NMR metabolome analysis resulted to be a promising approach to describe the phenotypic variation that occurs among dogs fed different diets. The metabolomic approach is becoming always more important in the evaluation of the functional responses of animals to dietary intervention. NMR-metabolomics has emerged as a non-destructive technique that allows a simpler data interpretation compared to other techniques. NMR metabolome analysis resulted to be a promising approach to describe the phenotypic variation that occurs among dogs fed different diets.
DOI: 10.6084/m9.figshare.17068363
title: Preliminary results on the efficacy of a dietary supplement combined with physiotherapy in dogs with osteoarthritis on biomarkers of oxidative stress and inflammation

description: The purpose of this study was to evaluate the effects of a supplement containing <i>Cannabis sativa</i> oil and other plant derivatives (<i>Boswellia serrata</i> Roxb. and <i>Zingiber officinale</i> phytosomized extracts) combined with physiotherapy treatments in dogs with osteoarthritis. We evaluated the response of serum inflammatory and oxidative stress biomarkers to the treatment. We found a significant reduction in the levels of serum markers reflecting the strong anti-inflammatory and antioxidant properties of the supplement under study.HIGHLIGHTSDiet supplements are a valid alternative therapy in dogs with osteoarthritis.Evidence of anti-inflammatory and antioxidant properties of a supplement containing <i>Cannabis sativa</i> oil and other plant derivatives (<i>Boswellia serrata</i> Roxb. and <i>Zingiber officinale</i>). Diet supplements are a valid alternative therapy in dogs with osteoarthritis. Evidence of anti-inflammatory and antioxidant properties of a supplement containing <i>Cannabis sativa</i> oil and other plant derivatives (<i>Boswellia serrata</i> Roxb. and <i>Zingiber officinale</i>).
DOI: 10.6084/m9.figshare.17068363.v1
title: Preliminary results on the efficacy of a dietary supplement combined with physiotherapy in dogs with osteoarthritis on biomarkers of oxidative stress and inflammation

description: The purpose of this study was to evaluate the effects of a supplement containing <i>Cannabis sativa</i> oil and other plant derivatives (<i>Boswellia serrata</i> Roxb. and <i>Zingiber officinale</i> phytosomized extracts) combined with physiotherapy treatments in dogs with osteoarthritis. We evaluated the response of serum inflammatory and oxidative stress biomarkers to the treatment. We found a significant reduction in the levels of serum markers reflecting the strong anti-inflammatory and antioxidant properties of the supplement under study.HIGHLIGHTSDiet supplements are a valid alternative therapy in dogs with osteoarthritis.Evidence of anti-inflammatory and antioxidant properties of a supplement containing <i>Cannabis sativa</i> oil and other plant derivatives (<i>Boswellia serrata</i> Roxb. and <i>Zingiber officinale</i>). Diet supplements are a valid alternative therapy in dogs with osteoarthritis. Evidence of anti-inflammatory and antioxidant properties of a supplement containing <i>Cannabis sativa</i> oil and other plant derivatives (<i>Boswellia serrata</i> Roxb. and <i>Zingiber officinale</i>).
DOI: 10.5281/zenodo.6956313
title: Stable Water Isotopes and Nutrients in the Changjiang (Yangtze River) Estuary and adjacent East China Sea shelf in Winter

description: The dataset presented here includes the temperature, salinity, stable water isotopes, and nutrients of seawater from the Changjiang Estuary and adjacent East China Sea shelf in March 2013.
description: Nutrients data are provided by the Ocean Data Center, National Natural Science Foundation of China (NSFCODC: http://www.nsfcodc.cn/).
DOI: 10.5281/zenodo.5091156
title: Stable Water Isotopes and Nutrients in the Changjiang (Yangtze River) Estuary and adjacent East China Sea shelf in Winter

description: The dataset presented here includes the temperature, salinity, stable water isotopes, and nutrients of seawater from the Changjiang Estuary and adjacent East China Sea shelf in March 2013.
description: Nutrients data are provided by the Ocean Data Center, National Natural Science Foundation of China (NSFCODC: http://www.nsfcodc.cn/).
DOI: 10.6084/m9.figshare.16613527.v3
title: Geomorphology of the southwest Sinus Sabaeus region: evidence for an ancient hydrological cycle on Mars

description: We have produced a 1:650,000 scale geomorphological map of the southwest Sinus Sabaeus, a region of Mars approximately centered at 25.0<sup>°</sup>S and 6.5<sup>°</sup>E and located in the topographic transition between Arabia Terra and Noachis Terra, in the Martian highlands. This heavily cratered region, subjected to extensive surface erosion, shows a complex valley network system known as Marikh Vallis. In this work, we study the history and role of water in and around Marikh Vallis, focusing on the modification and evolution of this area during the earliest Martian times, the Noachian period. The map described in this paper was produced through the analysis of a combination of available imagery data, topography, and thermal inertia, which together allow defining different geomorphological units in this area. This new map provides a basis for identifying the ancient presence of water in the region, both in the liquid state and in the ice phase.
DOI: 10.3886/e110663v1-124600
title: National Neighborhood Data Archive (NaNDA): Land Cover by Census Tract, United States, 2001-2016

description: This dataset contains measures of land cover (e.g., low-, medium-, or high-density development, forest, wetland, open water) derived from the National Land Cover Database (NLCD) and aggregated by US census tract. Land cover is measured both in total square meters and as a proportion of all land within the tract.
description: All census tracts in the continental United States. No data is available for Alaska, Hawaii, or the United States territories. Smallest Geographic Unit: census tract
DOI: 10.6084/m9.figshare.14936064
title: Survival after acute episodes of immune-mediated thrombotic thrombocytopenic purpura (iTTP) – cognitive functioning and health-related quality of life impact: a descriptive cross-sectional survey of adults living with iTTP in the United Kingdom

description: Immune-mediated thrombotic thrombocytopenic purpura (iTTP) is an ultra-rare life-threatening thrombotic microangiopathy affecting adults with unpredictable disease onset and acute presentation. This study aimed to describe the health-related quality of life (HRQoL), cognitive functioning and work productivity of survivors following acute episode(s) of iTTP in the United Kingdom (UK). An online survey was developed in collaboration with the TTPNetwork. Descriptive statistics were calculated for the health questionnaire Short Form Survey-36 Version 2 (SF-36v2), the Hospital Anxiety and Depression Score (HADS), the PROMIS Cognitive Function Abilities Subset – Short Form 6a (PROMIS CFAS – SF6a), and the Work Productivity and Activity Index: Specific Health Problem (WPAI-SHP), along with several iTTP-specific bespoke questions. Fifty participants were recruited between July-November 2019. The mean (standard deviation [SD]) standardized SF-36v2 physical and mental component scores were 42.16 (9.59) and 33.61 (12.34), lower than population norms. The mean (SD) standardized PROMIS CFAS – SF6a score was 39.69 (7.86), lower than population norms. HADS mean (SD) scores of 12.18 (3.14) and 11.78 (2.36) indicated moderate levels of anxiety and depression, respectively. Of those employed (58%), approximately 42.73% of participants reported work productivity loss due to their iTTP. Participants also reported experiencing flashbacks, fatigue interference in family, social and intimate life, and fears of relapse. Regardless of recency of the last acute episode, participant scores signified impairments in all domains. Remission from an acute episode of disease does not signify the conclusion of care, but rather the requirement for long-term healthcare particularly focused on psychological support.
DOI: 10.6084/m9.figshare.14936064.v1
title: Survival after acute episodes of immune-mediated thrombotic thrombocytopenic purpura (iTTP) – cognitive functioning and health-related quality of life impact: a descriptive cross-sectional survey of adults living with iTTP in the United Kingdom

description: Immune-mediated thrombotic thrombocytopenic purpura (iTTP) is an ultra-rare life-threatening thrombotic microangiopathy affecting adults with unpredictable disease onset and acute presentation. This study aimed to describe the health-related quality of life (HRQoL), cognitive functioning and work productivity of survivors following acute episode(s) of iTTP in the United Kingdom (UK). An online survey was developed in collaboration with the TTPNetwork. Descriptive statistics were calculated for the health questionnaire Short Form Survey-36 Version 2 (SF-36v2), the Hospital Anxiety and Depression Score (HADS), the PROMIS Cognitive Function Abilities Subset – Short Form 6a (PROMIS CFAS – SF6a), and the Work Productivity and Activity Index: Specific Health Problem (WPAI-SHP), along with several iTTP-specific bespoke questions. Fifty participants were recruited between July-November 2019. The mean (standard deviation [SD]) standardized SF-36v2 physical and mental component scores were 42.16 (9.59) and 33.61 (12.34), lower than population norms. The mean (SD) standardized PROMIS CFAS – SF6a score was 39.69 (7.86), lower than population norms. HADS mean (SD) scores of 12.18 (3.14) and 11.78 (2.36) indicated moderate levels of anxiety and depression, respectively. Of those employed (58%), approximately 42.73% of participants reported work productivity loss due to their iTTP. Participants also reported experiencing flashbacks, fatigue interference in family, social and intimate life, and fears of relapse. Regardless of recency of the last acute episode, participant scores signified impairments in all domains. Remission from an acute episode of disease does not signify the conclusion of care, but rather the requirement for long-term healthcare particularly focused on psychological support.
DOI: 10.6084/m9.figshare.13625237
title: Hodgkin lymphoma involving extranodal sites in head and neck: report of twenty-nine cases and review of three-hundred and fifty-seven cases

description: Hodgkin lymphoma (HL) involving the Waldeyer's ring (WR) and other extranodal head and neck sites are rare. We report our experience and PubMed literature review. Retrospective single institution cohort study using lymphoma data base and PubMed literature search using twenty-six various search terms. Twenty-nine patients were treated in our institution (1975–2018). Male:Female 22:7, median age at diagnosis 33 years (15–64), stages I–II:III–IV 25:4. Sites were nasopharynx (10), tonsil (9), parotid (5), mandible (2) and others (3). 20/29 patients received radiation therapy, 22/29 received chemotherapy. Ten years overall-survival and progression-free survival are 92% and 66% respectively. PubMed search showed 8766 citations and identified 357 patients including our patients. Male:Female 199:131, median age 45 years (5-89). Stages I–II in 286 (80%). Involvement was nasopharynx 109 (30.5%), tonsil 67 (18.8%), parotid 58 (16.2%), thyroid 45 (12.6%), adenoid 10 (2.8%), mandible 10 (2.8%) and others in 58 (16.2%). Pathology: mixed cellularity 99 (27.7%), nodular sclerosis 88 (24.6%), nodular lymphocyte-predominant 56 (15.7%), lymphocyte rich 25 (7%), classical-HL-not otherwise specified 16 (4.5%) and lymphocyte depleted 7 (2%) patients. Treatment details are available for 233 patients; 165 (46%) received radiation therapy, 137 (38%) chemotherapy. Complete remission in 208 (58%), progressive disease 14 (4%), no information 135 (38%). Overall, treatment failure in 54 (15%). Thirty (8.4%) have died; 21 disease related. KM overall-survival at 5 and 10 years was 88.5% and 77.6% respectively. This largest report showed that HL involving extranodal head and neck sites is not very uncommon and has excellent prognosis.
DOI: 10.6084/m9.figshare.13625237.v1
title: Hodgkin lymphoma involving extranodal sites in head and neck: report of twenty-nine cases and review of three-hundred and fifty-seven cases

description: Hodgkin lymphoma (HL) involving the Waldeyer's ring (WR) and other extranodal head and neck sites are rare. We report our experience and PubMed literature review. Retrospective single institution cohort study using lymphoma data base and PubMed literature search using twenty-six various search terms. Twenty-nine patients were treated in our institution (1975–2018). Male:Female 22:7, median age at diagnosis 33 years (15–64), stages I–II:III–IV 25:4. Sites were nasopharynx (10), tonsil (9), parotid (5), mandible (2) and others (3). 20/29 patients received radiation therapy, 22/29 received chemotherapy. Ten years overall-survival and progression-free survival are 92% and 66% respectively. PubMed search showed 8766 citations and identified 357 patients including our patients. Male:Female 199:131, median age 45 years (5-89). Stages I–II in 286 (80%). Involvement was nasopharynx 109 (30.5%), tonsil 67 (18.8%), parotid 58 (16.2%), thyroid 45 (12.6%), adenoid 10 (2.8%), mandible 10 (2.8%) and others in 58 (16.2%). Pathology: mixed cellularity 99 (27.7%), nodular sclerosis 88 (24.6%), nodular lymphocyte-predominant 56 (15.7%), lymphocyte rich 25 (7%), classical-HL-not otherwise specified 16 (4.5%) and lymphocyte depleted 7 (2%) patients. Treatment details are available for 233 patients; 165 (46%) received radiation therapy, 137 (38%) chemotherapy. Complete remission in 208 (58%), progressive disease 14 (4%), no information 135 (38%). Overall, treatment failure in 54 (15%). Thirty (8.4%) have died; 21 disease related. KM overall-survival at 5 and 10 years was 88.5% and 77.6% respectively. This largest report showed that HL involving extranodal head and neck sites is not very uncommon and has excellent prognosis.
DOI: 10.6084/m9.figshare.17036787.v1
title: Comprehensive DNA repair gene expression analysis and its prognostic significance in acute myeloid leukemia

description: Deficiency in DNA damage response (DDR) pathway and accumulation of DNA damage increases mutation rates resulting in genomic instability and eventually increases the risk of cancer. The aim of our study was to investigate expressions of DNA repair genes as new prognostic biomarkers in acute myeloid leukemia (AML). We utilized The Cancer Genome Atlas AML project (TCGA-LAML cohort, 15 acute promyelocytic leukemia (APL) and 155 non-APL AML) for the expression data of DNA repair genes. For validation, clinical samples (Ewha study group, 9 APL and 72 non-APL AML patients) were analyzed for the expression of 22 DNA repair genes using a custom RT<sup>2</sup> Profiler PCR Array. APL patients presented significantly lower expression of DNA repair genes than non-APL AML patients in both study groups. Among non-APL AML patients, high expression levels of <i>PARP1</i>, <i>XRCC1</i>, and <i>RAD51</i> were associated with poor overall survival (OS) probability in both study groups. Furthermore, Cox regression analysis showed that increased expression levels of <i>PARP1</i>, <i>XRCC1</i>, <i>RAD51, BRCA1</i> and <i>MRE11A</i> could be independent risk factors for OS in the Ewha study group. Among non-APL patients of the Ewha study group, the OS probability of DDR-overexpressed group with at least one gene or more showing Z score greater than 1.5 was poorer than that of DDR non-overexpressed group. In the current study, the DNA repair gene expression profile of APL patients was different from that of non-APL AML patients. Overexpression of DNA repair genes could be a poor prognostic biomarker in non-APL AML.
DOI: 10.6084/m9.figshare.17036787
title: Comprehensive DNA repair gene expression analysis and its prognostic significance in acute myeloid leukemia

description: Deficiency in DNA damage response (DDR) pathway and accumulation of DNA damage increases mutation rates resulting in genomic instability and eventually increases the risk of cancer. The aim of our study was to investigate expressions of DNA repair genes as new prognostic biomarkers in acute myeloid leukemia (AML). We utilized The Cancer Genome Atlas AML project (TCGA-LAML cohort, 15 acute promyelocytic leukemia (APL) and 155 non-APL AML) for the expression data of DNA repair genes. For validation, clinical samples (Ewha study group, 9 APL and 72 non-APL AML patients) were analyzed for the expression of 22 DNA repair genes using a custom RT<sup>2</sup> Profiler PCR Array. APL patients presented significantly lower expression of DNA repair genes than non-APL AML patients in both study groups. Among non-APL AML patients, high expression levels of <i>PARP1</i>, <i>XRCC1</i>, and <i>RAD51</i> were associated with poor overall survival (OS) probability in both study groups. Furthermore, Cox regression analysis showed that increased expression levels of <i>PARP1</i>, <i>XRCC1</i>, <i>RAD51, BRCA1</i> and <i>MRE11A</i> could be independent risk factors for OS in the Ewha study group. Among non-APL patients of the Ewha study group, the OS probability of DDR-overexpressed group with at least one gene or more showing Z score greater than 1.5 was poorer than that of DDR non-overexpressed group. In the current study, the DNA repair gene expression profile of APL patients was different from that of non-APL AML patients. Overexpression of DNA repair genes could be a poor prognostic biomarker in non-APL AML.
DOI: 10.6084/m9.figshare.13489365
title: Pretreatment grade 4 thrombocytopenia is an independent prognostic factor in adult acute lymphoblastic leukemia: an extended analysis of a single-center retrospective study

description: <b>Objectives:</b> Low pretreatment platelet count is negatively associated with overall survival (OS) of certain subtypes of acute lymphoblastic leukemia (ALL). However, the prognostic impact of the grade of thrombocytopenia on OS and disease-free survival (DFS) has never been explored. <b>Methods:</b> We conducted an extended analysis of a retrospective study. Newly diagnosed adults with ALL was enrolled in this study. The grade of thrombocytopenia was evaluated in accordance with the Common Terminology Criteria for Adverse Events (CTCAE) version 3.0. Prognostic impacts were assessed by the hazard ratios (HRs) and 95% confidence intervals (CIs) obtained from univariate and multivariate Cox proportional hazards regression analyses. <b>Results:</b> A total of 90 participants were included in this study. There were 18 cases with grade 4 thrombocytopenia among the 71 participants presented with thrombocytopenia of any grade. Both univariate and multivariate Cox regression analyses suggested the independent negative prognostic impact of grade 4 thrombocytopenia on both OS (HR = 4.73, 95% CI = 1.95-11.52) and DFS (HR = 9.82, 95% CI = 3.14-30.76) of adult ALL, using the cohort of patients with no thrombocytopenia as a reference. In addition, treatment regimen, cytogenetic profile, time to treatment, and platelet count were independent prognostic factors of the OS. We also found that treatment regimen, cytogenetic profile, and peripheral blood blast percentage were independent prognostic factors of the DFS. <b>Conclusion:</b> Grade 4 thrombocytopenia was a negative prognostic factor for both overall survival and disease-free survival of adults with acute lymphoblastic leukemia.
DOI: 10.6084/m9.figshare.13489365.v1
title: Pretreatment grade 4 thrombocytopenia is an independent prognostic factor in adult acute lymphoblastic leukemia: an extended analysis of a single-center retrospective study

description: <b>Objectives:</b> Low pretreatment platelet count is negatively associated with overall survival (OS) of certain subtypes of acute lymphoblastic leukemia (ALL). However, the prognostic impact of the grade of thrombocytopenia on OS and disease-free survival (DFS) has never been explored. <b>Methods:</b> We conducted an extended analysis of a retrospective study. Newly diagnosed adults with ALL was enrolled in this study. The grade of thrombocytopenia was evaluated in accordance with the Common Terminology Criteria for Adverse Events (CTCAE) version 3.0. Prognostic impacts were assessed by the hazard ratios (HRs) and 95% confidence intervals (CIs) obtained from univariate and multivariate Cox proportional hazards regression analyses. <b>Results:</b> A total of 90 participants were included in this study. There were 18 cases with grade 4 thrombocytopenia among the 71 participants presented with thrombocytopenia of any grade. Both univariate and multivariate Cox regression analyses suggested the independent negative prognostic impact of grade 4 thrombocytopenia on both OS (HR = 4.73, 95% CI = 1.95-11.52) and DFS (HR = 9.82, 95% CI = 3.14-30.76) of adult ALL, using the cohort of patients with no thrombocytopenia as a reference. In addition, treatment regimen, cytogenetic profile, time to treatment, and platelet count were independent prognostic factors of the OS. We also found that treatment regimen, cytogenetic profile, and peripheral blood blast percentage were independent prognostic factors of the DFS. <b>Conclusion:</b> Grade 4 thrombocytopenia was a negative prognostic factor for both overall survival and disease-free survival of adults with acute lymphoblastic leukemia.
DOI: 10.3886/e128862v1-124601
title: National Neighborhood Data Archive (NaNDA): Land Cover by ZIP Code Tabulation Area, United States, 2001-2016

description: This dataset contains measures of land cover (e.g., low-, medium-, or high-density development, forest, wetland, open water) derived from the National Land Cover Database (NLCD) and aggregated by United States ZIP code tabulation area (ZCTA). Land cover is measured both in total square meters and as a proportion of all land within the ZCTA.
description: All ZIP code tabulation areas in the continental United States. No data is available for Alaska, Hawaii, or the United States territories.. Smallest Geographic Unit: ZIP code tabulation area
description: A ZIP code to ZCTA crosswalk must be used to combine this dataset with ZIP code geocoded data must use a ZIP code to ZCTA crosswalk. Such a crosswalk is available on the UDS Mapper website at https://udsmapper.org/zip-code-to-zcta-crosswalk/. Sample code for merging the UDS Mapper crosswalk with NaNDA datasets is available on the NaNDA repository at https://www.openicpsr.org/openicpsr/project/120088/.
DOI: 10.5519/qd.v6xrhk7t
title: Query on the Natural History Museum Data Portal (data.nhm.ac.uk) (989 records)