cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.22310047
title: Supplementary Material for: Headache in Pediatric Moyamoya Disease after Revascularization Surgery

description: <b><i>Introduction:</i></b> Patients with moyamoya disease (MMD) often have headaches after successful revascularization surgery. We aimed to characterize headache in surgically treated MMD patients and elucidate its clinical meaning and pathophysiology. <b><i>Methods:</i></b> Headache and related symptoms were surveyed using structured questionnaires in pediatric MMD patients with follow-up for 6 months or longer after indirect revascularization surgery. Clinical information including initial presentation, surgical method, and outcome was collected from medical records. Surgical outcomes were assessed clinically and by perfusion imaging. We defined “headache associated with MMD” as the headache accompanied by a transient ischemic attack or provoked by hyperventilation. Other headaches were further classified based on the diagnostic criteria of the International Headache Society-3. We analyzed the characteristics of “headache associated with MMD” and newly developed headache after surgery. <b><i>Results:</i></b> Among 90 participants, 65 (72.2%) had headaches within the last year before survey, including 28 (43.1%) with “headaches associated with MMD,” 10 (15.3%) with probable migraines, 2 (3.1%) with infrequent episodic tension-type headaches, and 4 (6.2%) with probable tension-type headaches. Headache quality was pulsatile in 27 (41.5%) patients and pressing or tightening in 27 (41.5%) patients. Nausea or vomiting was accompanied in 30 (46.2%) patients. Headache upon awakening was reported in 37 (57.8%) patients. Headache disturbed daily life in 12 (18.5%) patients. Among the 32 (35.6%) patients who suffered headache during both the pre- and postoperative period, the headache quality was similar in 27 (84.4%) patients, and its severity decreased in 24 (75.0%) and did not change in 8 (25.0%) patients. Twelve (13.3%) patients experienced newly developed headaches after surgery. Among them, six (50.0%) were classified as having “headaches associated with MMD.” They were predominantly electric shock-like or stabbing in 5 (45.6%) patients and nondisturbing in all patients. All 90 patients achieved improvement of ischemic symptoms after surgery. <b><i>Conclusion:</i></b> Headaches often persist or newly develop after revascularization surgery in MMD patients. Accompanying nausea or vomiting and occurrence upon awakening are characteristic features. Postoperative headache does not necessarily imply insufficient disease control.
DOI: 10.6084/m9.figshare.22360054
title: Supplementary Material for: Supervised, Self-Administered Tablet-Based Cognitive Assessment in Neurodegenerative Disorders and Stroke

description: <b><i>Introduction:</i></b> As the population ages, the prevalence of cognitive impairment is expanding. Given the recent pandemic, there is a need for remote testing modalities to assess cognitive deficits in individuals with neurological disorders. Self-administered, remote, tablet-based cognitive assessments would be clinically valuable if they can detect and classify cognitive deficits as effectively as traditional in-person neuropsychological testing. <b><i>Methods:</i></b> We tested whether the Miro application, a tablet-based neurocognitive platform, measured the same cognitive domains as traditional pencil-and-paper neuropsychological tests. Seventy-nine patients were recruited and then randomized to either undergo pencil-and-paper or tablet testing first. Twenty-nine age-matched healthy controls completed the tablet-based assessments. We identified Pearson correlations between Miro tablet-based modules and corresponding neuropsychological tests in patients and compared scores of patients with neurological disorders with those of healthy controls using <i>t</i> tests. <b><i>Results:</i></b> Statistically significant Pearson correlations between the neuropsychological tests and their tablet equivalents were found for all domains with moderate (<i>r</i> &gt; 0.3) or strong (<i>r</i> &gt; 0.7) correlations in 16 of 17 tests (<i>p</i> &lt; 0.05). All tablet-based subtests differentiated healthy controls from neurologically impaired patients by <i>t</i> tests except for the spatial span forward and finger tapping modules. Participants reported enjoyment of the tablet-based testing, denied that it provoked anxiety, and noted no preference between modalities. <b><i>Conclusions:</i></b> This tablet-based application was found to be widely acceptable to participants. This study supports the validity of these tablet-based assessments in the differentiation of healthy controls from patients with neurocognitive deficits in a variety of cognitive domains and across multiple neurological disease etiologies.
DOI: 10.6084/m9.figshare.22559995
title: Supplementary Material for: Robotic-Assisted Bronchoscopy Integrated with 3D-Fluoroscopy for Sampling Bilateral Pulmonary Nodules in a Single Procedure

description: Bronchoscopic biopsy of peripheral pulmonary nodules has evolved in recent years with the emergence of new technologies such as shape-sensing robotic-assisted bronchoscopy. The use of three-dimensional (3D) fluoroscopy for intraoperative visualization of the biopsy tool in relation to the target nodule aims to overcome computed tomography-to-body divergence encountered during the procedure and allows for more accurate sampling to improve adequacy and diagnostic performance. Until now, the robotic-assisted navigation plan and 3D transprocedural imaging function as separate systems. We present a case where intraoperative 3D fluoroscopy images were integrated to the robotic bronchoscopy navigation system, resulting in a single, dynamic, real-time 3D virtual plan showing readjusted paths towards the lesion displayed in the robotic bronchoscopy navigation system, allowing in this case, biopsying two bilateral pulmonary nodules resulting in different diagnosis within the same anesthetic procedure.
DOI: 10.6084/m9.figshare.24278122
title: Supplementary Material for: Effectiveness of antibiotics for uncomplicated diverticulitis: A retrospective investigation using a nationwide database in Japan

description: Introduction: The efficacy of antibiotics for diverticulitis without abscess or peritonitis (uncomplicated diverticulitis) is controversial. We aimed to investigate the effectiveness of antibiotics for uncomplicated diverticulitis. Methods: We collected admissions data for patients with acute uncomplicated diverticulitis using a nationwide database. We divided eligible admissions into two groups according to antibiotics initiation within 2 days after admission (antibiotic group vs. non-antibiotic group). We conducted propensity score matching and compared the rates of surgery (intestinal resection and stoma creation), in-hospital death, and medical costs between the groups. We also performed multivariate analysis to identify the clinical factors that affect surgery using data before propensity score matching. Results: We enrolled 131,936 admissions; among these, we obtained 6061 pairs after propensity score matching. Rates of both intestinal resection and stoma creation in the antibiotic group were lower than those in the non-antibiotic group (0.61% vs. 3.09%, P &lt; 0.0001 and 0.08% vs. 0.26%, P = 0.027, respectively). Median costs in the antibiotic group were higher than those in the non-antibiotic group (315,820 JPY vs. 300,175 JPY, P &lt; 0.0001, respectively). Multivariate analysis showed that non-initiation of antibiotics within 2 days after admission was a clinical factor that increased the risk of intestinal resection (odds ratio [OR] = 5.19, 95% confidence interval [CI]: 4.38‒6.16, P &lt; 0.0001) and stoma creation (OR = 2.68, 95% CI: 1.53‒4.70, P = 0.0006). Conclusion: Our results indicated that antibiotics for uncomplicated diverticulitis expected moderate to severe disease activity may reduce the risk of intestinal resection and stoma creation. Further investigations are warranted.
DOI: 10.17632/r9c59639pg.1
title: TMI-Asia v1.1

description: Data of the Transition Metal Emission Inventory TMI-Asia v1.1 (GrADS format).
This data includes emissions of 10 types of metals (Fe, Cu, Mn, Pb, Va, Zn, Co, Ni, Cd, Cr) of PM2.5 or PM10 particle size from 9 sectors (aviation, domestic, industry,  international navigation, other transport, power plants (non-point sources), power plants (non-point sources in Japan), power plants (large point sources), road transport).
DOI: 10.17632/ygwxphz2p4.1
title: TMI-Asia&Japan v1.1_metal contents

description: Metal content (%) in PM2.5 or PM10 emitted from each sector used in TMI-Japan v1.1.
DOI: 10.17882/92690
title: Gridded geophysical shipboard data on the South Intra-Transform segment of the St. Paul transform system (COLMEIA cruise)

description: Gridded shipboard multibeam bathymetry and gravity datasets acquired during the COLMEIA cruise (2013). Gridded sediment thickness derived from seismic data. Gridded crustal thickness computed from gravity. The gridded datasets cover the South intra-transform segment of the St. Paul transform fault system. Grids created with the GMT software. Grid details as follows: Bathymetry: Grid file format: nf = GMT netCDF format (32-bit float), CF-1.7 x_min: -26.6678081446 x_max: -24.4991923884 x_inc: 0.000898349526186 name: longitude n_columns: 2415 y_min: 0.416125587833 y_max: 0.917145899441 y_inc: 0.000904368793517 name: latitude n_rows: 555 Sediment thickness: Grid file format: nf = GMT netCDF format (32-bit float), CF-1.7 x_min: -26.6697086826 x_max: -24.4984586826 x_inc: 0.00225 name: longitude n_columns: 966 y_min: 0.4154644221 y_max: 0.9194644221 y_inc: 0.00225 name: latitude n_rows: 225 Free air anomaly (merged shipboard and satellite data): Grid file format: nf = GMT netCDF format (32-bit float), CF-1.7 x_min: -26.6666666667 x_max: -24.5 x_inc: 0.0166666666667 (1 min) name: longitude n_columns: 131 y_min: 0.416666666667 y_max: 0.916666666667 y_inc: 0.0166666666667 (1 min) name: latitude n_rows: 31 Gravity anomalies (Mantle Bouguer, Residual Mantle Bouguer): Grid file format: nf = GMT netCDF format (32-bit float), CF-1.7 x_min: -26.6666666667 x_max: -24.5 x_inc: 0.00333333333333 (12 sec) name: longitude n_columns: 651 y_min: 0.416666666667 y_max: 0.916666666667 y_inc: 0.00333333333333 (12 sec) name: latitude n_rows: 151 Crustal thickness derived from the gravity anomalies: Grid file format: nf = GMT netCDF format (32-bit float), CF-1.7 x_min: -26.6666666667 x_max: -24.5 x_inc: 0.00333333333333 (12 sec) name: longitude n_columns: 651 y_min: 0.416666666667 y_max: 0.916666666667 y_inc: 0.00333333333333 (12 sec) name: latitude n_rows: 151
DOI: 10.5281/zenodo.7512561
title: Targeted sensors for glutamatergic neurotransmission

description: Raw and derived data for Figure 9 and supplements
DOI: 10.6084/m9.figshare.21532425
title: Supplementary Material for: Calcified Epidural Hematoma after Conservative Treatment of Acute Epidural Hematoma in the Pediatric Population: A Systematic Review

description: <b><i>Background:</i></b> Acute traumatic epidural hematoma (EDH) is a complication in 2–3% of pediatric head injuries. Surgery is mandatory in symptomatic cases; otherwise, conservative treatment is a valid approach, especially in the pediatric population. Ossified epidural hematomas (OEHs) have been reported in the pediatric population as a rare complication of conservative EDH management, although the exact incidence remains unknown. The progressive increase in conservative management may lead to increases in the OEH incidence over the next few years. Our study aimed to systematically review OEH incidence, management strategies, characteristics (thickness, inner/outer calcifications), complication rates, time to surgery after the EDH diagnosis, and clinical outcomes. <b><i>Summary:</i></b> A systematic review was conducted in accordance with the PRISMA guidelines. Studies reporting diagnoses and clear descriptions of OEH after EDH in pediatric patients were considered eligible. Sixteen studies, including 18 pediatric patients aged 0–18 years, were included. Head trauma was the most common cause of OEH. Seven (38.8%) OEHs were treated less than 1 month after EDH diagnosis. Surgery was performed in 17 cases (94.44%), while 1 asymptomatic case (5.56%) was managed conservatively. <b><i>Key Messages:</i></b> Surgery was the most commonly used treatment for OEH. Data for conservative treatment of OEH are limited. Magnetic resonance imaging or ultrasound within the first 2 months, to check for EDH resolution, may be crucial to rule out complications in pediatric patients.
DOI: 10.6084/m9.figshare.21975530
title: Supplementary Material for: Probable Sarcopenia, Obesity, and Risk of All-Cause Mortality: A Pooled Analysis of 4,612 Participants

description: <b><i>Introduction:</i></b> Conflicting evidence exists concerning whether having sarcopenic obesity has additive mortality risk over having only sarcopenia or obesity. We examined the independent and combined associations of obesity and probable sarcopenia with all-cause mortality. <b><i>Methods:</i></b> The pooled analysis included three large, harmonized datasets (Health 2000 Survey; Health, Aging and Body Composition Study; Longitudinal Aging Study Amsterdam) with mortality follow-up data on individuals aged 70 years and over at baseline (<i>n</i> = 4,612). Obesity indicators included body mass index and waist circumference, and probable sarcopenia was defined based on grip strength. The mixed effects Cox model was used for statistical analyses, adjusting for age, sex, marital status, education, race, physical activity, alcohol consumption, smoking, and baseline diseases. <b><i>Results:</i></b> Risk of death increased for those having probable sarcopenia only (hazard ratio [HR]: 1.61, 95% confidence interval [CI]: 1.39–1.85) or probable sarcopenia with obesity (HR: 1.36, 95% CI: 1.13–1.64) but not for the obese-only group (HR: 0.92, 95% CI: 0.85–1.01), when compared to non-obese non-sarcopenic individuals. The results were similar regardless of adjustments for covariates or different obesity criteria applied. <b><i>Conclusion:</i></b> Probable sarcopenia, whether combined with obesity or not, is associated with increased mortality. Obesity did not increase mortality among older adults. Maintaining muscle strength and identifying older adults at risk of sarcopenia is important for the prevention of premature mortality.
DOI: 10.6084/m9.figshare.22127279
title: Supplementary Material for: Clinicopathological features of Gitelman syndrome with proteinuria and renal dysfunction

description: Introduction. Gitelman syndrome (GS) is a rare renal tubular salt-wasting disorder. Besides kidney electrolytes loss, proteinuria and renal dysfunction were also observed. However, their incidence, risk factors, pathological features, and prognosis were unclear. Methods. We retrospectively reviewed 116 GS patients and analyzed their clinical, genetic, and pathological characteristics. We also systematically reviewed articles on GS with proteinuria and renal dysfunction. Results. Twenty-three GS patients had proteinuria (69.6%) and renal dysfunction (43.5%) with a mean age of 35.3 ±13.2 years and 65.2% were male. Compared to patients without proteinuria or renal dysfunction, these patients had elevated plasma angiotensin II level (440.2±351.7 vs. 253.2±187.4 pg/ml, P=0.031) and three times higher incidence of diabetes. The renal pathology of nine biopsied patients indicated hypertrophy of the juxtaglomerular apparatus (100%), chronic tubulointerstitial changes (66.7%), intrarenal vascular changes (66.7%), and glomerulopathy (55.6%). More extensive renin staining was observed in patients with GS than in the control group with glomerular minor lesion (P&lt;0.001). During a median of 85 months (range, 11-205 months) follow-up for 19 out of the 23 GS-renal patients, the renal function was generally stable, except one died of cancer and one developed end-stage renal disease because of concomitant membranous nephropathy and IgA nephropathy. Conclusion. Proteinuria and renal dysfunction were more common than expected and might indicate glomerulopathy and vascular lesions besides a tubulointerstitial injury in GS. Renal function may maintain stable with effective therapy in most cases.
DOI: 10.6084/m9.figshare.22274623
title: Supplementary Material for: Subcutaneous adipose tissue is associated with acute kidney injury after abdominal trauma based on the generalized propensity score approach: A retrospective cohort study

description: Introduction: Obesity is associated with an increased risk of acute kidney injury (AKI) after trauma. However, the associations between different adipose tissue depots and AKI remain unknown. Our study aims to quantify the effect of abdominal adiposity on AKI in trauma patients. Methods: We performed a retrospective cohort study of abdominal trauma patients who were admitted into our hospital from January 2010 to March 2020. Abdominal VAT (visceral adipose tissue) and SAT (subcutaneous adipose tissue) were measured at the level of the third lumbar vertebra using computed tomography. Causal modeling based on the generalized propensity score was used to quantify the effects of BMI (body mass index), VAT and SAT on AKI. Results: Among 324 abdominal trauma patients, 67 (20.68%) patients developed AKI. Patients with AKI had higher BMI (22.46 kg/m2 vs. 22.04 kg/m2, P = 0.014), higher SAT areas (89.06 cm2 vs. 83.39 cm2, P = 0.151) and VAT areas (140.02 cm2 vs. 91.48 cm2, P = 0.001) than those without AKI. By using causal modeling, we found that the risk of developing AKI increased by 8.3% (P = 0.001) and 4.8% (P = 0.022) with one unit increase in BMI (per 1 kg/m2), and ten units increase in SAT (per 10 cm2), respectively. However, VAT did not show a significant association with AKI (P = 0.327). Conclusion: SAT, but not VAT, increased the risk of AKI among abdominal trauma patients. Measurement of SAT might help to identify patients at higher risk of AKI.
DOI: 10.6084/m9.figshare.23803959
title: Supplementary Material for: Association of lifelong cognitive reserve with dementia and mild cognitive impairment among older adults with limited formal education: a population-based cohort study

description: Introduction: Early-life educational attainment contributes to cognitive reserve (CR). We investigated the associations of lifelong CR with dementia and mild cognitive impairment (MCI) among older people with limited formal education. Methods: This population-based cohort study included 2127 dementia-free participants (≥60 years; 59.4% women; 81.5% with no or elementary school) who were examined at baseline (August-December 2014) and follow-up (March-September 2018). Lifelong CR score at baseline was generated from six lifespan intellectual factors. Dementia, MCI, and their subtypes were defined according to the international criteria. Data were analyzed using Cox proportional-hazards models. Results: During the total of 8330.6 person-years of follow-up, 101 persons were diagnosed with dementia, including 74 with AD and 26 with VaD. The high (versus low) tertile of lifelong CR score was associated with multivariable-adjusted hazards ratio (95% confidence interval) of 0.28 (0.14–0.55) for dementia and 0.18 (0.07–0.48) for AD. The association between higher CR and reduced AD risk was significant in people aged 60-74 but not in those aged≥75 years (P-for-interaction=0.011). Similarly, among MCI-free people at baseline (n=1635), the high (versus low) tertile of lifelong CR score was associated with multivariable-adjusted hazard ratio of 0.51 (0.38–0.69) for MCI and 0.46 (0.33–0.64) for amnestic MCI. Lifelong CR was not related to VaD or non-amnestic MCI. Discussion: High lifelong CR is associated with reduced risks of dementia and MCI, especially AD and amnestic MCI. It highlights the importance of lifelong CR in in maintaining late-life cognitive health even among people with no or limited education.
DOI: 10.6084/m9.figshare.21866067
title: Supplementary Material for: Challenges and Approach to Identifying Individuals with Salt Sensitivity of Blood Pressure

description: Background: Salt sensitivity of blood pressure (SSBP) is a trait observed in both humans and animals, characterized by an increase in blood pressure (BP) following salt loading or a drop in BP following salt depletion. Summary: This “intermediate” phenotype has been reported in a sizable portion of individuals regardless of their hypertensive status; hypertensives (27-51%), normotensives (18-47%). Further, in epidemiological studies, this phenotype is associated with increased adverse cardiovascular outcomes, risk factors, and reduced survival rates. Here in, we review the challenges in the assessment of SSBP, heterogeneity in the assessment method and protocols, and how these differences could affect the results. Further, we review how to identify individuals with SSBP in the clinic by using clinical and genetic data. No clinical approach has yet provided sufficient sensitivity and specificity to identify those with SSBP. Thus, SSBP is not routinely identified in the clinic. Current genetic data suggest that genotyping may support such an office approach. To date, studies in18 genes have provided sufficient evidence and reproducible data to identify potential mechanisms involved in subsets of subjects with hypertension and SSBP. Key message: Proof-of-concept clinical trials using genetic biomarkers to determine and treat individuals with SSBP are ongoing. Their results will provide critical evidence to support genetic-focused, mechanistically driven algorithms to identify and treat, specifically, individuals with SSBP—personalized medicine.
DOI: 10.6084/m9.figshare.23295227
title: Supplementary Material for: Comparison between two different handgrip systems and protocols on force reduction in handgrip assessment

description: INTRODUCTION Fatigue resistance (FR) can be assessed as the time during which grip strength (GS) drops to 50% of its maximum during a sustained maximal voluntary contraction. For the first time we compared force-time characteristics during FR test between two different handgrip systems, and investigated age- and clinical-related differences in order to verify if a briefer test protocol (i.e. until 75%) could be sufficiently informative. METHODS A cohort of young healthy (Y, &lt;30y, 24±3y, 54% women), middle-aged (MA, 30-65y, 47±11y, 54% women) and older (OLD, &gt;65y, 77±7y, 50% women) community-dwelling persons, and hospitalized patients (HOSP, 84±5y, 50% women) performed the FR test. For this purpose, an adapted Vigorimeter (original rubber bulb of the Martin Vigorimeter connected to a Unik 5000 pressure gauge) here defined as “pneumatic handgrip system” (Pneu) and Dynamometer G200 system (original Jamar Dynamometer handle with an in-build strength gauge) here defined as “hydraulic handgrip system” (Hydr) were used. Force-time curves were analysed from 100%-75% and from 75%-50% of the initial maximal GS during the FR test. The area under the curve (GW) was calculated by integrating the actual GS at each time interval (i.e. 1/5000s) and corrected for body weight (GW/body weight). RESULTS For both systems we found fair associations between FR100-50 and FR100-75 (Pneu mean difference=50.1s (95%CI:47.9-52.4), r2=0.48; Hydr mean difference=28.4s (95%CI:27.0-29.7), r2=0.52, all p&lt;0.001), and also moderate associations between GW(100-50)/body weight and GW(100-75)/body weight (Pneu mean difference=32.1kPa*s/kg (95%CI:30.6-33.6), r2=0.72; Hydr mean difference = 8.1kg*s/kg (95%CI:7.7-8.6), r2 = 0.68, all p&lt;0.001). Between MA and OLD we found a significant age-related difference in the GW results in the first 25% strength decay for Pneu (respectively 10.2±0.6kPa*s/kg against 7.1±1.2kPa*s/kg). DISCUSSION/CONCLUSION The brief test protocol is valid. Differences within the first 25% strength decay in GW between OLD and HOSP were identified when using Pneu, but not when using Hydr. Therefore, a brief FR test protocol using a continuous registration of the strength decay seems to be sufficiently informative in a clinical setting to appraise muscle fatigability, however, only when using a Pneu system.