cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.17632/xd4b2xmxn3.1
title: Impact of Comorbid Anxiety and Depression on Pregnancy Outcomes in Women with Gestational Hypertension: A Case-Control Study

description: Objective: To investigate the prevalence of anxiety and depression in patients with gestational hypertension and its impact on pregnancy outcomes.
Methods: A case-control study was conducted, involving 446 patients with gestational hypertension and 200 healthy pregnant women as controls. Anxiety and depression levels were assessed using the Self-rated Anxiety Scale (SAS) and the Self-rated Depression Scale (SDS). The incidence rates of anxiety and depression between the two groups. Univariate analysis and multivariate logistic regression were used to explore factors influencing anxiety and depression. Pregnancy and perinatal outcomes were compared using chi-square tests and t-tests. 
Results: The incidence of comorbid anxiety and depression in the gestational hypertension group (20.9%) was significantly higher than in the control group (7.0%, P &lt;0.05). Univariate analysis showed that there were statistical differences in the incidence of anxiety and depression at different educational levels, whether there was a history of adverse pregnancy, whether there was gestational hypertension, and whether there was thyroid disease (P &lt;0.05). Multivariate logistic regression analysis showed that educational level, history of adverse pregnancy, and gestational hypertension were significant factors influencing the occurrence of anxiety and depression. The incidence rates of preterm birth, preeclampsia, postpartum haemorrhage, and low birth weight infants in the anxiety and depression group were significantly higher than those of the nonanxiety and depression group (P &lt;0.05).
Conclusions: Anxiety and depression are more prevalent in patients with gestational hypertension and are associated with adverse pregnancy outcomes. Routine psychological evaluation and intervention are recommended for this population to improve maternal and newborn health.
KEYWORDS: Gestational Hypertension; Anxiety; Depression; Pregnancy Outcomes
DOI: 10.25442/hku.26335093
title: Supporting data for thesis entitled "Soluble CUB Domain-containing Protein 1 promotes dysfunction-associated steatohepatitis through recruitment and activation of intrahepatic macrophages"

description: This dataset contains proteomics data supporting the thesis entitled "Soluble CUB Domain-containing Protein 1 promotes dysfunction-associated steatohepatitis through recruitment and activation of intrahepatic macrophages".Metabolic dysfunction-associated steatotic liver disease (MASLD), formly named non-alcoholic fatty liver disease, affects over 30% of the general population and 76% of obese individuals worldwide, making it the most prevalent chronic liver disease. Its advanced stage, metabolic dysfunction-associated steatohepatitis (MASH), is characterized by hepatic ballooning and lobular inflammation, posing a significant risk of progressing to fibrosis, cirrhosis, and hepatocarcinoma. MASH often coexists with a cluster of cardiometabolic diseases and has become the primary reason for liver transplantation. Consequently, there is an urgent need for effective strategies for non-invasive diagnosis and therapeutic intervention for MASH and its associated comorbidities. To address this pressing issue, we assembled a substantial cohort with liver biopsy and histological diagnosis and amassed a wealth of clinical and preclinical evidence pointing to secreted form of CDCP1 (sCDCP1) as a crucial mediator of MASH. Our findings hold the potential to facilitate the clinical implementation of circulating sCDCP1 as a pathogenic biomarker for the non-invasive diagnosis and precise management of MASH.
DOI: 10.25442/hku.26335093.v1
title: Supporting data for thesis entitled "Soluble CUB Domain-containing Protein 1 promotes dysfunction-associated steatohepatitis through recruitment and activation of intrahepatic macrophages"

description: This dataset contains proteomics data supporting the thesis entitled "Soluble CUB Domain-containing Protein 1 promotes dysfunction-associated steatohepatitis through recruitment and activation of intrahepatic macrophages".Metabolic dysfunction-associated steatotic liver disease (MASLD), formly named non-alcoholic fatty liver disease, affects over 30% of the general population and 76% of obese individuals worldwide, making it the most prevalent chronic liver disease. Its advanced stage, metabolic dysfunction-associated steatohepatitis (MASH), is characterized by hepatic ballooning and lobular inflammation, posing a significant risk of progressing to fibrosis, cirrhosis, and hepatocarcinoma. MASH often coexists with a cluster of cardiometabolic diseases and has become the primary reason for liver transplantation. Consequently, there is an urgent need for effective strategies for non-invasive diagnosis and therapeutic intervention for MASH and its associated comorbidities. To address this pressing issue, we assembled a substantial cohort with liver biopsy and histological diagnosis and amassed a wealth of clinical and preclinical evidence pointing to secreted form of CDCP1 (sCDCP1) as a crucial mediator of MASH. Our findings hold the potential to facilitate the clinical implementation of circulating sCDCP1 as a pathogenic biomarker for the non-invasive diagnosis and precise management of MASH.
DOI: 10.17632/xd4b2xmxn3.2
title: Impact of Comorbid Anxiety and Depression on Pregnancy Outcomes in Women with Gestational Hypertension: A Case-Control Study

description: Objective: To investigate the prevalence of anxiety and depression in patients with gestational hypertension and its impact on pregnancy outcomes.
Methods: A case-control study was conducted, involving 446 patients with gestational hypertension and 200 healthy pregnant women as controls. Anxiety and depression levels were assessed using the Self-rated Anxiety Scale (SAS) and the Self-rated Depression Scale (SDS). The incidence rates of anxiety and depression between the two groups. Univariate analysis and multivariate logistic regression were used to explore factors influencing anxiety and depression. Pregnancy and perinatal outcomes were compared using chi-square tests and t-tests. 
Results: The incidence of comorbid anxiety and depression in the gestational hypertension group (20.9%) was significantly higher than in the control group (7.0%, P &lt;0.05). Univariate analysis showed that there were statistical differences in the incidence of anxiety and depression at different educational levels, whether there was a history of adverse pregnancy, whether there was gestational hypertension, and whether there was thyroid disease (P &lt;0.05). Multivariate logistic regression analysis showed that educational level, history of adverse pregnancy, and gestational hypertension were significant factors influencing the occurrence of anxiety and depression. The incidence rates of preterm birth, preeclampsia, postpartum haemorrhage, and low birth weight infants in the anxiety and depression group were significantly higher than those of the nonanxiety and depression group (P &lt;0.05).
Conclusions: Anxiety and depression are more prevalent in patients with gestational hypertension and are associated with adverse pregnancy outcomes. Routine psychological evaluation and intervention are recommended for this population to improve maternal and newborn health.
KEYWORDS: Gestational Hypertension; Anxiety; Depression; Pregnancy Outcomes
DOI: 10.17632/34zwt9c4dt.1
title: ​Barriers to Entry, Entrepreneurship, and Income Inequality within the USA

description: Replication code and data for ​Barriers to Entry, Entrepreneurship, and Income Inequality within the USA Journal of Entrepreneurship and Public Policy. 11(4): 332-356. 2022.
DOI: 10.25442/hku.26317237
title: Supporting data for "Investigating the neuroprotective effects of resistance exercise on Alzheimer’s disease and acute systemic inflammatory challenge."

description: Alzheimer’s Disease (AD) is considered a multifactorial neurodegenerative disease as more than 90% of all AD cases are sporadic and without a clear pattern of genetic inheritance. Currently, there are no effective therapeutics to cure AD, and available drugs only aim to slow disease progression and provide symptomatic relief for patients. Physical exercise has long been recognized for its benefits to overall health, and numerous studies have shown that physical exercise improves cognition in older adults and cognitively impaired patients. However, resistance-type regimes remain poorly investigated. Ladder-based resistance exercise paradigm was established in two transgenic AD mouse models, 3×Tg-AD and 5×FAD, and was demonstrated to improve cognitive functions and reduce neuropathological markers such as mRNA expression of pro-inflammatory cytokines, tau hyperphosphorylation, and glial cell activation. Notably, an increase in muscle strength and expression of peroxisome proliferator-activated receptor-gamma coactivator (PGC1-α) was only observed in 3×Tg-AD mice. The duration of resistance exercise was determined to be a crucial factor, as ten weeks did not yield the same neurological benefits as five weeks in 3×Tg-AD mice. Acute systemic activation of the immune system can negatively modulate the central nervous system, and the lack of exercise capacity is one of the factors associated with poor cognitive performance after acute surgical trauma and infection in patients. Furthermore, pre-existing cognitive impairment may impart susceptibility to accelerated cognitive decline following an acute systemic inflammatory episode. Given that resistance exercise can modulate the expression of inflammatory mediators in the brain and the periphery, its role as a potential prophylactic intervention against sterile and non-sterile systemic inflammatory challenges was examined using the experimental models of laparotomy under sevoflurane anesthesia and peripheral administration of lipopolysaccharide (LPS) in non-transgenic and 3×Tg-AD mice. In non-transgenic mice, the preconditioning with five weeks of resistance exercise reduced systemic and neuroinflammation and improved cognitive outcomes in the puzzle test compared to untrained mice after surgery or infection. The preconditioning of 3×Tg-AD mice with resistance exercise mitigated the heightened neuroinflammation and exacerbated cognitive decline caused by surgery or infection. These findings suggest resistance exercise as a therapeutic strategy for pre-existing cognitive impairment and a potent prophylactic against anti-inflammatory systemic inflammatory challenges.
DOI: 10.25442/hku.26317237.v1
title: Supporting data for "Investigating the neuroprotective effects of resistance exercise on Alzheimer’s disease and acute systemic inflammatory challenge."

description: Alzheimer’s Disease (AD) is considered a multifactorial neurodegenerative disease as more than 90% of all AD cases are sporadic and without a clear pattern of genetic inheritance. Currently, there are no effective therapeutics to cure AD, and available drugs only aim to slow disease progression and provide symptomatic relief for patients. Physical exercise has long been recognized for its benefits to overall health, and numerous studies have shown that physical exercise improves cognition in older adults and cognitively impaired patients. However, resistance-type regimes remain poorly investigated. Ladder-based resistance exercise paradigm was established in two transgenic AD mouse models, 3×Tg-AD and 5×FAD, and was demonstrated to improve cognitive functions and reduce neuropathological markers such as mRNA expression of pro-inflammatory cytokines, tau hyperphosphorylation, and glial cell activation. Notably, an increase in muscle strength and expression of peroxisome proliferator-activated receptor-gamma coactivator (PGC1-α) was only observed in 3×Tg-AD mice. The duration of resistance exercise was determined to be a crucial factor, as ten weeks did not yield the same neurological benefits as five weeks in 3×Tg-AD mice. Acute systemic activation of the immune system can negatively modulate the central nervous system, and the lack of exercise capacity is one of the factors associated with poor cognitive performance after acute surgical trauma and infection in patients. Furthermore, pre-existing cognitive impairment may impart susceptibility to accelerated cognitive decline following an acute systemic inflammatory episode. Given that resistance exercise can modulate the expression of inflammatory mediators in the brain and the periphery, its role as a potential prophylactic intervention against sterile and non-sterile systemic inflammatory challenges was examined using the experimental models of laparotomy under sevoflurane anesthesia and peripheral administration of lipopolysaccharide (LPS) in non-transgenic and 3×Tg-AD mice. In non-transgenic mice, the preconditioning with five weeks of resistance exercise reduced systemic and neuroinflammation and improved cognitive outcomes in the puzzle test compared to untrained mice after surgery or infection. The preconditioning of 3×Tg-AD mice with resistance exercise mitigated the heightened neuroinflammation and exacerbated cognitive decline caused by surgery or infection. These findings suggest resistance exercise as a therapeutic strategy for pre-existing cognitive impairment and a potent prophylactic against anti-inflammatory systemic inflammatory challenges.
DOI: 10.17632/72njy5z6b8.1
title: Water Quality Pollution Indices for Heavy Metal Contamination Monitoring

description: The degradation of water quality due to heavy metal (HM) contamination is significant and has significant impacts on both human health and aquatic ecosystems. Anthropogenic activities have contributed significantly to the increase in HM concentrations in aquatic environments and require continuous monitoring and assessment. This study focuses on the assessment of HM pollution indices (HPI, HEI and DC) in the Styr River, before and after a nuclear power plant water discharge. The water samples were collected from two locations and analyzed for HM concentrations using ICP-OES. The data were then statistically processed. The results indicate comparable HM concentrations at both sites, reflecting a homogeneous distribution of contamination. The calculated indices classify the pollution level as low, which suggests a relatively stable environmental condition. Pearson correlation analysis shows strong associations between HM concentrations and pollution indices, highlighting the utility of these indices in identifying pollution trends and the relationships between specific HM and pollution indices. Overall, this study underscores the importance of monitoring and assessing HM pollution using comprehensive indices for effective water quality management.
DOI: 10.17632/f3vs77s7sm.1
title: Efficiency in Response to a Changing Climate by Agribusiness SMEs in Kiambu and Kajiado Counties, Kenya

description: Primary data was gathered from 383 owners or managers of agribusiness SMEs in the study sites of Kiambu and Kajiado utilizing a multi-stage stratified sampling approach. The two Counties, Kiambu and Kajiado, were divided into 15 sub-counties and 19 towns, which were purposively selected for the study. Individual SMEs were then randomly chosen based on their willingness to participate and the inclusion of the 3 key business types: trading, manufacturing, and food service. The primary objective of the study was to investigate the weather-related risks that significantly impact these businesses, as well as the expenses related to weather impacts and adaptation responses incurred by these enterprises. Trained enumerators collected the data in December 2021 in Kajiado, and in January and February 2022 in Kiambu. Data consists of the attributes of the entrepreneur, the enterprise, and the SME environment, as well as the costs of the weather risks and of the responses taken.
DOI: 10.25442/hku.26310628
title: Supporting data for " Preventing dental erosion using silver diamine fluoride"

description: Dental erosion is the dissolution of the mineralised tooth surface caused by non-bacterial acids.Erosive tooth wear (ETW) is a result of demineralisation caused by erosive acid and abrasion.Silver diamine fluoride (SDF) is one of the polyvalent metal fluorides. SDF has not been widely investigated on dentalerosion prevention.To now, the effect of SDF on dental erosion is available only a few evidence-based research, which mainly conducted on bovine tooth samples. The promising anti-erosive properties of SDF from previous studies were more acid resistance and more silver compounds precipitated on SDF-treated surfaces. It is necessary to study the effectiveness of SDF against dental erosion on human enamel and dentine samples.
DOI: 10.25442/hku.26310628.v1
title: Supporting data for " Preventing dental erosion using silver diamine fluoride"

description: Dental erosion is the dissolution of the mineralised tooth surface caused by non-bacterial acids.Erosive tooth wear (ETW) is a result of demineralisation caused by erosive acid and abrasion.Silver diamine fluoride (SDF) is one of the polyvalent metal fluorides. SDF has not been widely investigated on dentalerosion prevention.To now, the effect of SDF on dental erosion is available only a few evidence-based research, which mainly conducted on bovine tooth samples. The promising anti-erosive properties of SDF from previous studies were more acid resistance and more silver compounds precipitated on SDF-treated surfaces. It is necessary to study the effectiveness of SDF against dental erosion on human enamel and dentine samples.
DOI: 10.25442/hku.26244680
title: Supporting data for "Alkyl-Nitrene and -Carbene C(sp<sup><strong>3</strong></sup>)–H Insertion Reactions Catalyzed by Iron and Ruthenium Complexes with Macrocyclic N<sub><strong>4</strong></sub> Ligands"

description: This dataset contains the data for my PhD thesis entitled "Alkyl-Nitrene and -Carbene C(sp<sup><strong>3</strong></sup>)–H Insertion Reactions Catalyzed by Iron and Ruthenium Complexes with Macrocyclic N<sub><strong>4</strong></sub> Ligands". The data set includes raw data for characterizations (e.g., NMR spectra, HPLC data, UV/Vis absorption spectra and X-ray crystal structures, etc.) and computations (i.e., outputs of DFT calculations).
DOI: 10.25442/hku.26244680.v1
title: Supporting data for "Alkyl-Nitrene and -Carbene C(sp<sup><strong>3</strong></sup>)–H Insertion Reactions Catalyzed by Iron and Ruthenium Complexes with Macrocyclic N<sub><strong>4</strong></sub> Ligands"

description: This dataset contains the data for my PhD thesis entitled "Alkyl-Nitrene and -Carbene C(sp<sup><strong>3</strong></sup>)–H Insertion Reactions Catalyzed by Iron and Ruthenium Complexes with Macrocyclic N<sub><strong>4</strong></sub> Ligands". The data set includes raw data for characterizations (e.g., NMR spectra, HPLC data, UV/Vis absorption spectra and X-ray crystal structures, etc.) and computations (i.e., outputs of DFT calculations).
DOI: 10.15468/dl.64cvfm
title: Occurrence Download

description: A dataset containing 10 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is BOLD:ACH7135"
 ]
}

 The dataset includes 10 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0043124-240626123714530/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.25442/hku.26242229
title: <i>Supporting data for “Reinventing Colonial Legacy in A Worlding City: </i><i>Rethinking Gentrification in Central Shanghai, China</i><i>”</i>

description: The notion of gentrification links global forces (e.g. neoliberalism, globalisation) with local responses (e.g. redevelopment, conservation) at the neighbourhood level. With a focus on central Shanghai, this thesis first unpacks how (both symbolic and material) colonial legacy serves as key resources to attract transnational gentrifiers/(re)investments and displace less affluent classes in the contemporary gentrification process. Second, this study examines the constantly changing interplay between the state, market and society to unravel the driving forces, processes, and social consequences in various waves and forms of gentrification. Third, particular focus is given to the role of the (traditional and digital) media in contemporary (re)gentrification, examining the influence exerted by the market, state and society on media narratives and representations.The dataset consists of web-scraped Weibo data in three case studies. Weibo, launched by Sina Corporations, was selected as the representative social media platform for several reasons. First, Weibo boasts the largest user base among Chinese social media platforms, with over 0.5 billion active users. This vase user base provides a huge amount of information that can be utilised to analyse public perceptions of gentrifying/gentrified neighbourhoods. Second, the features of Weibo are more like a fusion of Twitter and Instagram, making it easier to align findings on Weibo with existing research on Twitter and Instagram. Third, Weibo, the first Chinese-style microblog platform launched in August 2009, provides long-term data spanning over a decade, facilitating the track of changing media portrayals of gentrification over time.To obtain sufficient data, the Chinese terms ‘JianYeLi’, ‘WuKang Road, ‘AnFu Road’ were respectively chosen as the initial keywords for data collection using a web-crawler tool. Specifically, each scraped post contained a social media ID, a timestamp, textual content, image URLs, and received likes/shares/comments. The initial dataset consisted of nearly 50,000 posts between 2011 and 2021. Since the main focus is on how social media users reflect the gentrification of selected neighbourhoods, forwarded and irrelevant posts were first cleaned, and only the used subsampled datasets were uploaded. As the posts were public-facing, individual user permission was not sought.