cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.22308876
title: Effects of a monocomponent protease from Bacillus licheniformis on broiler performance, digestibility, and carcass yield

description: ABSTRACT. Two experiments were carried out to evaluate the effects of protease addition to the diet of broilers at a higher level (1× or 2×) than the nutritional value proposed for the enzyme. The first experiment, 1280 day-old chicks (Cobb500®) were randomly allocated (randomized block design, 2×2+1 factorial arrangement), five treatments, eight replicates containing 32 birds/replicate. Treatments consisted: control diet without protease (CD); CD + 1× nutritional value of the enzyme (CDM1); CD + 2× nutritional value of the enzyme (CDM2); CDM1 + protease; and CDM2 + protease. The experimental period was 42 days. The mean weight (AFW), feed intake (FI), weight gain (WG), feed conversion, and carcass yield were evaluated. Significant differences were observed for AFW, WG, FI, abdominal fat yield, and feet percentage in the carcass. In the second experiment, 120 Cobb500® chicks at 14 days of age were allotted in a completely randomized design, 2×2+1 factorial arrangement, five treatments, six replicates with four birds/replicate. The treatments were consistent with the first experiment. Significant improvements in the nitrogen balance were observed for the broilers that received protease. The use of the enzyme tested is recommended with the recommended nutritional matrix, improving the zootechnical indices of broilers.
DOI: 10.6084/m9.figshare.22308876.v1
title: Effects of a monocomponent protease from Bacillus licheniformis on broiler performance, digestibility, and carcass yield

description: ABSTRACT. Two experiments were carried out to evaluate the effects of protease addition to the diet of broilers at a higher level (1× or 2×) than the nutritional value proposed for the enzyme. The first experiment, 1280 day-old chicks (Cobb500®) were randomly allocated (randomized block design, 2×2+1 factorial arrangement), five treatments, eight replicates containing 32 birds/replicate. Treatments consisted: control diet without protease (CD); CD + 1× nutritional value of the enzyme (CDM1); CD + 2× nutritional value of the enzyme (CDM2); CDM1 + protease; and CDM2 + protease. The experimental period was 42 days. The mean weight (AFW), feed intake (FI), weight gain (WG), feed conversion, and carcass yield were evaluated. Significant differences were observed for AFW, WG, FI, abdominal fat yield, and feet percentage in the carcass. In the second experiment, 120 Cobb500® chicks at 14 days of age were allotted in a completely randomized design, 2×2+1 factorial arrangement, five treatments, six replicates with four birds/replicate. The treatments were consistent with the first experiment. Significant improvements in the nitrogen balance were observed for the broilers that received protease. The use of the enzyme tested is recommended with the recommended nutritional matrix, improving the zootechnical indices of broilers.
DOI: 10.6084/m9.figshare.22308877
title: Cerebrospinal fluid: a target of some fungi and an overview

description: Meningitis is a potentially life-threatening infection characterised by the inflammation of the leptomeningeal membranes. The estimated annual prevalence of 8.7 million cases globally and the disease is caused by many different viral, bacterial, and fungal pathogens. Although several genera of fungi are capable of causing infections in the central nervous system (CNS), the most significant number of registered cases have, as causal agents, yeasts of the genus Cryptococcus. The relevance of cryptococcal meningitis has changed in the last decades, mainly due to the increase in the number of people living with human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) and medications that impair the immune responses. In this context, coronavirus disease 19 (COVID-19) has also emerged as a risk factor for invasive fungal infections (IFI), including fungal meningitis (FM), due to severe COVID-19 disease is associated with increased pro-inflammatory cytokines, interleukin (IL)-1, IL-6, and tumour necrosis factor-alpha, reduced CD4-interferon-gamma expression, CD4 and CD8 T cells. The gold standard technique for fungal identification is isolating fungi in the culture of the biological material, including cerebrospinal fluid (CSF). However, this methodology has as its main disadvantage the slow or null growth of some fungal species in culture, which makes it difficult to finalise the diagnosis. In conclusions, this article, in the first place, point that it is necessary to accurately identify the etiological agent in order to assist in the choice of the therapeutic regimen for the patients, including the implementation of actions that promote the reduction of the incidence, lethality, and fungal morbidity, which includes what is healthy in the CNS.
DOI: 10.6084/m9.figshare.22308877.v1
title: Cerebrospinal fluid: a target of some fungi and an overview

description: Meningitis is a potentially life-threatening infection characterised by the inflammation of the leptomeningeal membranes. The estimated annual prevalence of 8.7 million cases globally and the disease is caused by many different viral, bacterial, and fungal pathogens. Although several genera of fungi are capable of causing infections in the central nervous system (CNS), the most significant number of registered cases have, as causal agents, yeasts of the genus Cryptococcus. The relevance of cryptococcal meningitis has changed in the last decades, mainly due to the increase in the number of people living with human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) and medications that impair the immune responses. In this context, coronavirus disease 19 (COVID-19) has also emerged as a risk factor for invasive fungal infections (IFI), including fungal meningitis (FM), due to severe COVID-19 disease is associated with increased pro-inflammatory cytokines, interleukin (IL)-1, IL-6, and tumour necrosis factor-alpha, reduced CD4-interferon-gamma expression, CD4 and CD8 T cells. The gold standard technique for fungal identification is isolating fungi in the culture of the biological material, including cerebrospinal fluid (CSF). However, this methodology has as its main disadvantage the slow or null growth of some fungal species in culture, which makes it difficult to finalise the diagnosis. In conclusions, this article, in the first place, point that it is necessary to accurately identify the etiological agent in order to assist in the choice of the therapeutic regimen for the patients, including the implementation of actions that promote the reduction of the incidence, lethality, and fungal morbidity, which includes what is healthy in the CNS.
DOI: 10.6084/m9.figshare.22308880
title: Predicting Significant Coronary Obstruction in a Population with Suspected Coronary Disease and Absence of Coronary Calcium: CORE-64 / CORE320 Studies

description: Abstract Background Coronary artery calcium (CAC) scanning can be performed using non-contrast computed tomography to predict cardiovascular events, but has less value for risk stratification in symptomatic patients. Objective To identify and validate predictors of significant coronary obstruction (SCO) in symptomatic patients without coronary artery calcification. Methods A total of 4,258 participants were screened from the CORE64 and CORE320 studies that enrolled patients referred for invasive angiography, and from the Quanta Registry that included patients referred for coronary computed tomography angiography (CTA). Logistic regression models evaluated associations between cardiovascular risk factors, CAC, and SCO. An algorithm to assess the risk of SCO was proposed for patients without CAC. Significance level of 5% was used in the analyses. Results Of the 509 participants of the CORE study, 117 (23%) had zero coronary calcium score; 13 (11%) patients without CAC had SCO. Zero calcium score was related to younger age, female gender, lower body mass index, no diabetes, and no dyslipidemia. Being a current smoker increased ~3.5 fold the probability of SCO and other CV risk factors were not significantly associated. Considering the clinical findings, an algorithm to further stratify zero calcium score patients was proposed and had a limited performance in the validation cohort (AUC 58; 95%CI 43, 72). Conclusion A lower cardiovascular risk profile is associated with zero calcium score in a setting of high-risk patients. Smoking is the strongest predictor of SCO in patients without CAC.
DOI: 10.6084/m9.figshare.22308880.v1
title: Predicting Significant Coronary Obstruction in a Population with Suspected Coronary Disease and Absence of Coronary Calcium: CORE-64 / CORE320 Studies

description: Abstract Background Coronary artery calcium (CAC) scanning can be performed using non-contrast computed tomography to predict cardiovascular events, but has less value for risk stratification in symptomatic patients. Objective To identify and validate predictors of significant coronary obstruction (SCO) in symptomatic patients without coronary artery calcification. Methods A total of 4,258 participants were screened from the CORE64 and CORE320 studies that enrolled patients referred for invasive angiography, and from the Quanta Registry that included patients referred for coronary computed tomography angiography (CTA). Logistic regression models evaluated associations between cardiovascular risk factors, CAC, and SCO. An algorithm to assess the risk of SCO was proposed for patients without CAC. Significance level of 5% was used in the analyses. Results Of the 509 participants of the CORE study, 117 (23%) had zero coronary calcium score; 13 (11%) patients without CAC had SCO. Zero calcium score was related to younger age, female gender, lower body mass index, no diabetes, and no dyslipidemia. Being a current smoker increased ~3.5 fold the probability of SCO and other CV risk factors were not significantly associated. Considering the clinical findings, an algorithm to further stratify zero calcium score patients was proposed and had a limited performance in the validation cohort (AUC 58; 95%CI 43, 72). Conclusion A lower cardiovascular risk profile is associated with zero calcium score in a setting of high-risk patients. Smoking is the strongest predictor of SCO in patients without CAC.
DOI: 10.6084/m9.figshare.22308882
title: GEOTHERMAL ENERGY: AN ALTERNATIVE TO THE WATER–ENERGY DILEMMA IN NORTHEASTERN BRAZIL

description: ABSTRACT This paper proposes geothermal energy as an alternative solution to the water–energy dilemma in the northeastern region of Brazil (NEB). The main application of this study was to provide a theoretical basis to support a different approach to policies minimizing water scarcity and ensuring sustainability. The analysis developed in this study compares the levelized cost of electricity (LCOE) for many different energy sources. The novelty of this study is the use of geothermal energy in the context of the Brazilian Northeast, focusing on water desalination processes, which are expensive in terms of energy. Therefore, this study is highly important because it offers the potential of addressing the energy/economic barrier related to water desalination in environments with economically viable geothermal energy. This is the case in Northeast Brazil with potential for reuse of abandoned oil wells. In the form of enhanced geothermal systems (EGS), geothermal energy is a competitive energy source compared to other sources in the Brazilian Energy Matrix, especially when considering factors in addition to the economic benefits. In the form of EGS, geothermal energy is a suitable option for addressing water scarcity in the northeast region in a sustainable and low-emission manner. This is a strategic opportunity for NEB in the context of energy production and freshwater production through desalination.
DOI: 10.6084/m9.figshare.22308882.v1
title: GEOTHERMAL ENERGY: AN ALTERNATIVE TO THE WATER–ENERGY DILEMMA IN NORTHEASTERN BRAZIL

description: ABSTRACT This paper proposes geothermal energy as an alternative solution to the water–energy dilemma in the northeastern region of Brazil (NEB). The main application of this study was to provide a theoretical basis to support a different approach to policies minimizing water scarcity and ensuring sustainability. The analysis developed in this study compares the levelized cost of electricity (LCOE) for many different energy sources. The novelty of this study is the use of geothermal energy in the context of the Brazilian Northeast, focusing on water desalination processes, which are expensive in terms of energy. Therefore, this study is highly important because it offers the potential of addressing the energy/economic barrier related to water desalination in environments with economically viable geothermal energy. This is the case in Northeast Brazil with potential for reuse of abandoned oil wells. In the form of enhanced geothermal systems (EGS), geothermal energy is a competitive energy source compared to other sources in the Brazilian Energy Matrix, especially when considering factors in addition to the economic benefits. In the form of EGS, geothermal energy is a suitable option for addressing water scarcity in the northeast region in a sustainable and low-emission manner. This is a strategic opportunity for NEB in the context of energy production and freshwater production through desalination.
DOI: 10.6084/m9.figshare.22308883
title: Cancer patients with COVID-19: does prior nutritional risk associated with cancer indicate a poor prognosis for COVID-19?

description: ABSTRACT Objective To verify whether the presence of related nutritional risk indicators prior to COVID-19 diagnosis is associated with poor survival in patients with cancer. Methods We retrospectively analyzed the data of hospitalized cancer patients who tested positive for COVID-19 between March 2020 and February 2021. Nutritional risk was defined as the presence of one of the following characteristics: body mass index &lt;20kg/m 2 , scored Patient-generated Subjective Global Assessment ≥9 points or classification B, albumin level &lt;3.5g/dL, and C-reactive protein level ≥10mg/L, evaluated between 7 and 60 days prior to the date of patient inclusion. The endpoint measure was all-cause mortality within 30 days of COVID-19 diagnosis. Results A total of 253 patients were included, most of whom were elderly (62.4%) and female (63.6%). Overall, 45.4% of the patients were at nutritional risk. Survival was significantly lower in patients at nutritional risk (8 days; interquartile range [IQR]: 3-29) than in patients not at nutritional risk (16 days; IQR: 6-30) (p&lt;0.001). The presence of prior nutritional risk was associated with increased 30-day mortality (HR: 1.42; 95%CI: 1.03-1.94), regardless of age, gender, tumor site or stage, and other risk factors, and the model had good discrimination accuracy (concordance statistic: 0.744). Conclusion The presence of prior nutritional risk indicators is related to poor prognosis in patients with cancer and COVID-19, emphasizing the importance of nutritional care, notably during this pandemic.
DOI: 10.6084/m9.figshare.22308883.v1
title: Cancer patients with COVID-19: does prior nutritional risk associated with cancer indicate a poor prognosis for COVID-19?

description: ABSTRACT Objective To verify whether the presence of related nutritional risk indicators prior to COVID-19 diagnosis is associated with poor survival in patients with cancer. Methods We retrospectively analyzed the data of hospitalized cancer patients who tested positive for COVID-19 between March 2020 and February 2021. Nutritional risk was defined as the presence of one of the following characteristics: body mass index &lt;20kg/m 2 , scored Patient-generated Subjective Global Assessment ≥9 points or classification B, albumin level &lt;3.5g/dL, and C-reactive protein level ≥10mg/L, evaluated between 7 and 60 days prior to the date of patient inclusion. The endpoint measure was all-cause mortality within 30 days of COVID-19 diagnosis. Results A total of 253 patients were included, most of whom were elderly (62.4%) and female (63.6%). Overall, 45.4% of the patients were at nutritional risk. Survival was significantly lower in patients at nutritional risk (8 days; interquartile range [IQR]: 3-29) than in patients not at nutritional risk (16 days; IQR: 6-30) (p&lt;0.001). The presence of prior nutritional risk was associated with increased 30-day mortality (HR: 1.42; 95%CI: 1.03-1.94), regardless of age, gender, tumor site or stage, and other risk factors, and the model had good discrimination accuracy (concordance statistic: 0.744). Conclusion The presence of prior nutritional risk indicators is related to poor prognosis in patients with cancer and COVID-19, emphasizing the importance of nutritional care, notably during this pandemic.
DOI: 10.6084/m9.figshare.22308885
title: Construction and validation of an instrument to assess the care for prisoners living with HIV/AIDS

description: ABSTRACT This study aimed to build and validate indicators for the health care of those deprived of freedom living with HIV/AIDS, being a methodological development study carried out in two stages. In the first stage, there was the construction of indicators through a literature review in national and international databases. In the second stage, the content and appearance validation were performed using the Delphi technique method; ten judges specialized in the care of the person living with HIV/AIDS and practical performance in the prison environment participated in this stage, most of them being nurses working in prison units. After that, the internal consistency analysis was performed, and the instrument was applied to 10 health managers of prison units, and the Cronbach’s alpha coefficient was calculated. The instrument resulted in five dimensions: Physical Structure; Human Resources; Work Process Organization; Health Records; and Adherence to Treatment. The instrument obtained 80% of agreement from the judges regarding content and appearance. The overall Cronbach’s alpha was 0.90. The instrument was validated in appearance, content, and consistency for the evaluation of care to those deprived of freedom living with HIV/AIDS.
DOI: 10.6084/m9.figshare.22308885.v1
title: Construction and validation of an instrument to assess the care for prisoners living with HIV/AIDS

description: ABSTRACT This study aimed to build and validate indicators for the health care of those deprived of freedom living with HIV/AIDS, being a methodological development study carried out in two stages. In the first stage, there was the construction of indicators through a literature review in national and international databases. In the second stage, the content and appearance validation were performed using the Delphi technique method; ten judges specialized in the care of the person living with HIV/AIDS and practical performance in the prison environment participated in this stage, most of them being nurses working in prison units. After that, the internal consistency analysis was performed, and the instrument was applied to 10 health managers of prison units, and the Cronbach’s alpha coefficient was calculated. The instrument resulted in five dimensions: Physical Structure; Human Resources; Work Process Organization; Health Records; and Adherence to Treatment. The instrument obtained 80% of agreement from the judges regarding content and appearance. The overall Cronbach’s alpha was 0.90. The instrument was validated in appearance, content, and consistency for the evaluation of care to those deprived of freedom living with HIV/AIDS.
DOI: 10.5281/zenodo.5543734
title: Summary statistics of cell-type specific cis-eQTLs in eight brain cell-types

description: This dataset contains eQTL summary statistics for all SNPs-gene pairs in 8 major brain cell types (within 1MB window surrounding the TSS of each expressed gene). For each cell type, there is one file per chromosome. Column description: 1. Gene_id 2. SNP_id 3. Distance to TSS 4. Nominal p-value 5. Beta In addition, a file contains the SNP positions (snp_pos.txt) and tested allele. Update February 2023: The summary statistics from our 'tissue-like' analysis were added (pb[1-22].gz). These file contain eQTL summary statistics after aggregating all reads from all nuclei for each individual (instead of per cell type).
DOI: 10.5519/qd.8lp4ed2f
title: Query on the Natural History Museum Data Portal (data.nhm.ac.uk) (20 records)
DOI: 10.25502/x3fg-7q23/d
title: Data for survey on annual crops farming

description: Assessing indigenous knowledge on the judiciousness of agriculture management practices and measuring the impact of local farming practices on soil carbon and other soil nutrients and attributes to enhance sustainable agriculture, yield and climate change mitigation.
DOI: 10.6084/m9.figshare.22308892
title: Supplementary materials

description: original data
DOI: 10.6084/m9.figshare.22308892.v1
title: Supplementary materials

description: original data
DOI: 10.6084/m9.figshare.22190090.v1
title: Key performance indicators for small and medium-sized urban water systems in a semi-arid region: a case study of Okanagan Valley, Canada

description: Drinking water, wastewater, and stormwater are three components of an Urban Water System. Maintenance of these components requires evaluation of the existing performance of the water system. The evaluation becomes more significant in small and medium-sized water systems because these systems wrestle with various constraints, such as insufficient funds, inadequate infrastructure and water governance. In this study, Key Performance Indicators (KPIs) are identified for each UWS component considering six performance criteria. A questionnaire was distributed to water utilities across the Okanagan Valley. KPIs were identified by combining Delphi technique and Preference Ranking Organization Method for Enrichment Evaluation methods. Ninety-six KPIs were identified with 39, 30, and 27 KPIs for drinking water, wastewater, and stormwater. Based on the available literature, <i>agriculture water use, low impact development implementation (LID), average annual life cycle investment, and swimming advisories</i> are a few notable KPIs that are unique to the Valley.
DOI: 10.6084/m9.figshare.22190090
title: Key performance indicators for small and medium-sized urban water systems in a semi-arid region: a case study of Okanagan Valley, Canada

description: Drinking water, wastewater, and stormwater are three components of an Urban Water System. Maintenance of these components requires evaluation of the existing performance of the water system. The evaluation becomes more significant in small and medium-sized water systems because these systems wrestle with various constraints, such as insufficient funds, inadequate infrastructure and water governance. In this study, Key Performance Indicators (KPIs) are identified for each UWS component considering six performance criteria. A questionnaire was distributed to water utilities across the Okanagan Valley. KPIs were identified by combining Delphi technique and Preference Ranking Organization Method for Enrichment Evaluation methods. Ninety-six KPIs were identified with 39, 30, and 27 KPIs for drinking water, wastewater, and stormwater. Based on the available literature, <i>agriculture water use, low impact development implementation (LID), average annual life cycle investment, and swimming advisories</i> are a few notable KPIs that are unique to the Valley.
DOI: 10.5281/zenodo.7755275
title: Data of optimal IBO for battery-powered OFDM transmitter

description: Data generated by numeric calculations.
DOI: 10.5281/zenodo.7755274
title: Data of optimal IBO for battery-powered OFDM transmitter

description: Data generated by numeric calculations.
DOI: 10.7303/syn51072170.2
title: Systems Biology Dissection of PTSD and MDD across brain regions, cell-types and blood