cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.11834514
title: Additional file 1 of Six yearsâ€™ experience with LipidSeq: clinical and research learnings from a hybrid, targeted sequencing panel for dyslipidemias

description: Additional file 1: This additional file contains four supplemental tables, each in its own labelled tab. Table S1. Contains a description of each gene on the LipidSeq panel and what disorder or trait it is related to, as well its chromosmal coordinates. Table S2. Contains information on our phenotypic categorization of samples that have been sequenced using the LipidSeq panel design. Table S3. Contains annotated information on every unique variant we have identified from our entire cohort. Table S4. Contains a subset of annotated variants with CADD PHRED scores greater than or equal to 20.
DOI: 10.6084/m9.figshare.11834619.v1
title: Additional file 5 of Genome-wide association study (GWAS) reveals genetic loci of lead (Pb) tolerance during seedling establishment in rapeseed (Brassica napusÂ L.)

description: Additional file 5: Table S1. The phenotypic variation for RRLs in this natural rapeseed population. SE, Standard Error; CV, Coefficient of variation; RRL1, RRL2, RRL3 represent the relative RRL in replication 1, 2 and 3 respectively. RRL_Means was the average value of three RRLs; ** indicate significant correlation at the 1% level.
DOI: 10.6084/m9.figshare.11834628.v1
title: Additional file 6 of Genome-wide association study (GWAS) reveals genetic loci of lead (Pb) tolerance during seedling establishment in rapeseed (Brassica napus L.)

description: Additional file 6: Table S2. The details Pb-tolerant genotypes screeneded from 472 global-coolected rapeseeds. RL_CK and RL_Pb represent the radicle length (RL) under control and Pb stress (100 mg/L), respectively; RRL represent the relative radicle length.
DOI: 10.6084/m9.figshare.11834637.v1
title: Additional file 7 of Genome-wide association study (GWAS) reveals genetic loci of lead (Pb) tolerance during seedling establishment in rapeseed (Brassica napusÂ L.)

description: Additional file 7: Table S3. The information for top 20 enriched pathways for genes in the associated regions.
DOI: 10.6084/m9.figshare.11834640.v1
title: Additional file 3 of A combined microRNA and transcriptome analyses illuminates the resistance response of rice against brown planthopper

description: Additional file 3: Table S2. DEMs in both varieties before and after BPH feeding.
DOI: 10.6084/m9.figshare.11834514.v1
title: Additional file 1 of Six yearsâ€™ experience with LipidSeq: clinical and research learnings from a hybrid, targeted sequencing panel for dyslipidemias

description: Additional file 1: This additional file contains four supplemental tables, each in its own labelled tab. Table S1. Contains a description of each gene on the LipidSeq panel and what disorder or trait it is related to, as well its chromosmal coordinates. Table S2. Contains information on our phenotypic categorization of samples that have been sequenced using the LipidSeq panel design. Table S3. Contains annotated information on every unique variant we have identified from our entire cohort. Table S4. Contains a subset of annotated variants with CADD PHRED scores greater than or equal to 20.
DOI: 10.6084/m9.figshare.11834643.v1
title: Additional file 8 of Genome-wide association study (GWAS) reveals genetic loci of lead (Pb) tolerance during seedling establishment in rapeseed (Brassica napusÂ L.)

description: Additional file 8: Table S4. List of 472 rapeseed accessions used for association study.
DOI: 10.6084/m9.figshare.11834643
title: Additional file 8 of Genome-wide association study (GWAS) reveals genetic loci of lead (Pb) tolerance during seedling establishment in rapeseed (Brassica napusÂ L.)

description: Additional file 8: Table S4. List of 472 rapeseed accessions used for association study.
DOI: 10.6084/m9.figshare.11834646
title: Additional file 4 of A combined microRNA and transcriptome analyses illuminates the resistance response of rice against brown planthopper

description: Additional file 4: Table S3. DEMs at the early and late feeding stages of the two varieties.
DOI: 10.6084/m9.figshare.20222606
title: Additional file 2 of APEX1 regulates alternative splicing of key tumorigenesis genes in non-small-cell lung cancer

description: Additional file 2: Table S2. HiSeqV2 APEX1 expression box.
DOI: 10.6084/m9.figshare.11834667.v1
title: Additional file 2 of QTL mapping of yield component traits on bin map generated from resequencing a RIL population of foxtail millet (Setaria italica)

description: Additional file 2: Table S2. Bin markers and genotypes of 164 RILs.
DOI: 10.6084/m9.figshare.11834685.v1
title: Additional file 4 of QTL mapping of yield component traits on bin map generated from resequencing a RIL population of foxtail millet (Setaria italica)

description: Additional file 4: Table S4. Recombinant breakpoints and corresponding physical locations.
DOI: 10.6084/m9.figshare.11834697
title: Additional file 6 of QTL mapping of yield component traits on bin map generated from resequencing a RIL population of foxtail millet (Setaria italica)

description: Additional file 6: Table S6. The number of gene within physical interval of qGWP3.3, qSWP7.4 and qSWP9.1.
DOI: 10.6084/m9.figshare.19698942
title: Circular RNA CircSHKBP1 accelerates the proliferation, invasion, angiogenesis, and stem cell-like properties via modulation of microR-766-5p/high mobility group AT-hook 2 axis in laryngeal squamous cell carcinoma

description: Laryngeal squamous cell carcinoma (LSCC) is a common malignancy in head and neck. Circular SHKBP1 (circSHKBP) exerts momentous functions in the occurrence of many cancers including LSCC. Thus, we investigated the oncogenic capacities of circSHKBP1 in LSCC, and revealed the underlying mechanism as a competing endogenous RNA. The expression levels of circSHKBP1, miR-766-5p, and high mobility group AT-hook 2 (HMGA2) were examined by quantitative real-time PCR and their influences on the overall survival were measured by Kaplan–Meier method. The correlations between circSHKBP1 and miR-766-5p or HMGA2 were detected by Spearman’s rank correlation analysis. <i>In vitro</i>, the influences of circSHKBP1/miR-766-5p/HMGA2 axis on the tumorigenesis of LSCC were examined by CCK-8, transwell, sphere formation, and angiogenesis assays, respectively. circSHKBP1 expression was up-regulated in the LSCC specimens and cell lines. And elevated circSHKBP1 expression was closely linked to poor prognosis. Silencing circSHKBP1 expression restrained cell proliferation, invasion, angiogenesis, stem cell-like properties and tumor growth. We observed that miR-766-5p was down-regulated and negatively correlated to circSHKBP1 in LSCC samples. However, HMGA2 was highly expressed and positively associated with circSHKBP1 in these specimens. Importantly, the levels of circSHKBP1, miR-766-5p, and HMGA2 were closely associated with patients’ clinical parameters including lymph nodes metastasis and TNM stages. Mechanistic analysis clarified that circSHKBP1 sponged miR-766-5p to regulate HMGA2, the target of miR-766-5p. Moreover, miR-766-5p inhibition and overexpression of HMGA2 rescued the tumor-suppressing roles of circSHKBP1 downregulation in LSCC. In conclusion, circSHKBP1 accelerated the tumorigenesis of LSCC via modulating HMGA2 by targeting miR-766-5p.
DOI: 10.6084/m9.figshare.11834697.v1
title: Additional file 6 of QTL mapping of yield component traits on bin map generated from resequencing a RIL population of foxtail millet (Setaria italica)

description: Additional file 6: Table S6. The number of gene within physical interval of qGWP3.3, qSWP7.4 and qSWP9.1.
DOI: 10.6084/m9.figshare.11834604.v1
title: Additional file 10 of A combined microRNA and transcriptome analyses illuminates the resistance response of rice against brown planthopper

description: Additional file 10: Table S6. Integrated analysis of BPH resistance related miRNAs and their target genes.
DOI: 10.6084/m9.figshare.11834613.v1
title: Additional file 11 of A combined microRNA and transcriptome analyses illuminates the resistance response of rice against brown planthopper

description: Additional file 11: Table S7. Primer sequences for qRT-PCR and the transformation of rice protoplasts.
DOI: 10.6084/m9.figshare.6067613
title: The effect of normobaric oxygen in patients with acute stroke: a systematic review and meta-analysis

description: <b>Background</b> Normobaric oxygen (NBO) has received considerable attention due to controversial data in brain protection in patients with acute stroke. This study aims to analyze current data of NBO on brain protection as used in the clinic. <b>Methods</b> We searched for and reviewed relevant articles and references from Pubmed, Medline, Embase, Cochrane, and Clincialtrials.gov that were published prior to October 2017. Data from prospective studies were processed using RevMan5.0 software, provided by Cochrane collaboration and transformed using relevant formulas. <b>Results</b> A total of 11 prospective RCT studies including 6366 patients with acute stroke (NBO group, 3207; control group, 3159) were enrolled in this analysis. △NIHSS represented the values of NIHSS at 4, 24 h, or 7 days post-stroke minus baseline NIHSS. Compared to controls, there was a minor trend toward NBO benefits in short-term prognostic indices, as indicated by decreased ΔNIHSS at our defined time points. By contrast, NBO decreased Barthel Index scores between 3 and 7 months, and increased death rates at 3, 6 months, and 1 year, whereas, modified Rankin Scale scores between 3 and 6 months were unchanged. <b>Conclusions</b> The existing trends toward benefits revealed in this meta-analysis help us appreciate the promising value of NBO, although current evidence of NBO on improving clinical outcomes of stroke is insufficient. Well-designed multi-center clinical trials are encouraged and urgently needed to further explore the efficacy of NBO on brain protection.
DOI: 10.6084/m9.figshare.11834628
title: Additional file 6 of Genome-wide association study (GWAS) reveals genetic loci of lead (Pb) tolerance during seedling establishment in rapeseed (Brassica napus L.)

description: Additional file 6: Table S2. The details Pb-tolerant genotypes screeneded from 472 global-coolected rapeseeds. RL_CK and RL_Pb represent the radicle length (RL) under control and Pb stress (100 mg/L), respectively; RRL represent the relative radicle length.
DOI: 10.6084/m9.figshare.11834691.v1
title: Additional file 5 of QTL mapping of yield component traits on bin map generated from resequencing a RIL population of foxtail millet (Setaria italica)

description: Additional file 5: Table S5. The chi-squared tests of bin marker of RIL population.
DOI: 10.6084/m9.figshare.11834838
title: Additional file 12 of Comparative transcriptome analysis of inbred lines and contrasting hybrids reveals overdominance mediate early biomass vigor in hybrid cotton

description: Additional file 12. Enriched KEGG terms of overdominant genes in root of high hybrid-parent triad
DOI: 10.6084/m9.figshare.11834820.v1
title: Additional file 10 of Comparative transcriptome analysis of inbred lines and contrasting hybrids reveals overdominance mediate early biomass vigor in hybrid cotton

description: Additional file 10. Information on gene expression patterns in root and leaf of low hybrid relative to its parents
DOI: 10.6084/m9.figshare.11834640
title: Additional file 3 of A combined microRNA and transcriptome analyses illuminates the resistance response of rice against brown planthopper

description: Additional file 3: Table S2. DEMs in both varieties before and after BPH feeding.
DOI: 10.6084/m9.figshare.11834667
title: Additional file 2 of QTL mapping of yield component traits on bin map generated from resequencing a RIL population of foxtail millet (Setaria italica)

description: Additional file 2: Table S2. Bin markers and genotypes of 164 RILs.
DOI: 10.6084/m9.figshare.20222554.v1
title: Additional file 3 of Sequence, structure, and function of the Dps DNA-binding protein from Deinococcus wulumuqiensis R12

description: Additional file 3. MS_identified_information.
DOI: 10.6084/m9.figshare.11834847.v1
title: Additional file 13 of Comparative transcriptome analysis of inbred lines and contrasting hybrids reveals overdominance mediate early biomass vigor in hybrid cotton

description: Additional file 13. Enriched Go terms of overdominant genes in leaf of high hybrid-parent triad
DOI: 10.6084/m9.figshare.11834874
title: Additional file 17 of Comparative transcriptome analysis of inbred lines and contrasting hybrids reveals overdominance mediate early biomass vigor in hybrid cotton

description: Additional file 17. Enriched Go terms of overdominant genes in leaf of medium hybrid-parent triad
DOI: 10.6084/m9.figshare.11834874.v1
title: Additional file 17 of Comparative transcriptome analysis of inbred lines and contrasting hybrids reveals overdominance mediate early biomass vigor in hybrid cotton

description: Additional file 17. Enriched Go terms of overdominant genes in leaf of medium hybrid-parent triad
DOI: 10.6084/m9.figshare.20223402.v1
title: <i>OsMATE6</i> gene putatively involved in host defense response toward susceptibility against <i>Rhizoctonia solani</i> in rice

description: Sheath blight caused by <i>Rhizoctonia solani</i> AG1-IA is the second most serious disease of rice worldwide. Elucidating the role of multi-drug and toxic compound extrusion (<i>MATE</i>) gene family in host-pathogens interactions may uncover a new possible way to comprehend the mechanism of sheath blight resistance in rice<i>.</i> We foremost explored the role of <i>OsMATE</i> genes against <i>R. solani</i> resistance through comparative transcriptomics in PR114 (susceptible) and ShB-8 (moderately resistant) at 24 and 48 hpi (hours post-inoculation) of <i>R. solani</i> infection, respectively. Six <i>OsMATE</i> genes were differentially expressed and further validated through qRT-PCR. <i>OsMATE6</i> gene was identified as a potential candidate for sheath blight susceptibility as it was significantly up-regulated in PR114. <i>OsMATE6</i> is conserved within the wild relatives and might be translocated from <i>Oryza nivara</i> during the domestication of rice. Further studies are focused to verify its role by overexpression and protein interactions to understand the molecular mechanism of sheath blight resistance.
DOI: 10.6084/m9.figshare.11834898
title: Additional file 21 of Comparative transcriptome analysis of inbred lines and contrasting hybrids reveals overdominance mediate early biomass vigor in hybrid cotton

description: Additional file 21. Enriched Go terms of overdominant genes in leaf of low hybrid-parent triad
DOI: 10.6084/m9.figshare.20222573.v1
title: Additional file 3 of Circular RNA EIF4G3 suppresses gastric cancer progression through inhibition of β-catenin by promoting δ-catenin ubiquitin degradation and upregulating SIK1

description: Additional file 3:
DOI: 10.6084/m9.figshare.20222603
title: Additional file 1 of APEX1 regulates alternative splicing of key tumorigenesis genes in non-small-cell lung cancer

description: Additional file 1: Table S1. The primers for detecting alternative splicing events (ASEs).
DOI: 10.6084/m9.figshare.11834646.v1
title: Additional file 4 of A combined microRNA and transcriptome analyses illuminates the resistance response of rice against brown planthopper

description: Additional file 4: Table S3. DEMs at the early and late feeding stages of the two varieties.
DOI: 10.6084/m9.figshare.11834685
title: Additional file 4 of QTL mapping of yield component traits on bin map generated from resequencing a RIL population of foxtail millet (Setaria italica)

description: Additional file 4: Table S4. Recombinant breakpoints and corresponding physical locations.
DOI: 10.6084/m9.figshare.11834862
title: Additional file 15 of Comparative transcriptome analysis of inbred lines and contrasting hybrids reveals overdominance mediate early biomass vigor in hybrid cotton

description: Additional file 15. Enriched Go terms of overdominant genes in root of medium hybrid-parent triads
DOI: 10.6084/m9.figshare.11834919
title: Additional file 24 of Comparative transcriptome analysis of inbred lines and contrasting hybrids reveals overdominance mediate early biomass vigor in hybrid cotton

description: Additional file 24. List of Primers for quantitative RT-PCR
DOI: 10.6084/m9.figshare.11834946
title: Additional file 8 of Genome-wide identification of MAPKKK genes and their responses to phytoplasma infection in Chinese jujube (Ziziphus jujuba Mill.)

description: Additional file 8: Table S3. Number of introns and exons of ZjMAPKKK genes
DOI: 10.6084/m9.figshare.7116275
title: Additional file 4: of Genome-wide analysis of long non-coding RNAs in Catalpa bungei and their potential function in floral transition using high-throughput sequencing

description: Table S4. Summary of the read counts. (XLSX 14 kb)
DOI: 10.6084/m9.figshare.11834868.v1
title: Additional file 16 of Comparative transcriptome analysis of inbred lines and contrasting hybrids reveals overdominance mediate early biomass vigor in hybrid cotton

description: Additional file 16. Enriched KEGG terms of overdominant genes in root of medium hybrid-parent triad
DOI: 10.6084/m9.figshare.11834886.v1
title: Additional file 19 of Comparative transcriptome analysis of inbred lines and contrasting hybrids reveals overdominance mediate early biomass vigor in hybrid cotton

description: Additional file 19. Enriched Go terms of overdominant genes in root of low hybrid-parent triad
DOI: 10.6084/m9.figshare.11834892
title: Additional file 1 of Comparative transcriptome analysis of inbred lines and contrasting hybrids reveals overdominance mediate early biomass vigor in hybrid cotton

description: Additional file 1. Brief detail of sequencing, mapping and gene expressions of the individual library
DOI: 10.6084/m9.figshare.19699054
title: Eleutheroside E alleviates cerebral ischemia-reperfusion injury in a 5-hydroxytryptamine receptor 2C (Htr2c)-dependent manner in rats

description: Stroke is the central disorder underlined by ischemia-reperfusion (I/R) injury. Eleutheroside E (EE) is administered as the shield in some ischemia tissues with anti-inflammatory action. However, whether EE defends I/R-induced damage in the brain remains unknown. Here, we demonstrated that EE significantly alleviated the cerebral I/R injury and reduced the apoptosis of hippocampal neuron cells in rats. During the anti-apoptosis process, EE significantly upregulated the expression of 5-hydroxytryptamine receptor 2C (Htr2c) gene. Silencing Htr2c expression dramatically weakened the protective effect of EE on I/R-induced apoptosis of rat hippocampal neuron. EE-regulated Htr2c also remarkably inhibited the expression of caspase-3, −6 and −7, thereby suggesting a plausible anti-apoptosis mechanism associated with Htr2c/caspase axis. These findings elicit the potentially clinical strategy that targets Htr2c to improve outcome of ischemia brain.
DOI: 10.6084/m9.figshare.19699054.v1
title: Eleutheroside E alleviates cerebral ischemia-reperfusion injury in a 5-hydroxytryptamine receptor 2C (Htr2c)-dependent manner in rats

description: Stroke is the central disorder underlined by ischemia-reperfusion (I/R) injury. Eleutheroside E (EE) is administered as the shield in some ischemia tissues with anti-inflammatory action. However, whether EE defends I/R-induced damage in the brain remains unknown. Here, we demonstrated that EE significantly alleviated the cerebral I/R injury and reduced the apoptosis of hippocampal neuron cells in rats. During the anti-apoptosis process, EE significantly upregulated the expression of 5-hydroxytryptamine receptor 2C (Htr2c) gene. Silencing Htr2c expression dramatically weakened the protective effect of EE on I/R-induced apoptosis of rat hippocampal neuron. EE-regulated Htr2c also remarkably inhibited the expression of caspase-3, −6 and −7, thereby suggesting a plausible anti-apoptosis mechanism associated with Htr2c/caspase axis. These findings elicit the potentially clinical strategy that targets Htr2c to improve outcome of ischemia brain.
DOI: 10.6084/m9.figshare.11834907.v1
title: Additional file 22 of Comparative transcriptome analysis of inbred lines and contrasting hybrids reveals overdominance mediate early biomass vigor in hybrid cotton

description: Additional file 22. Enriched KEGG terms of overdominant genes in leaf of low hybrid-parent triad
DOI: 10.6084/m9.figshare.11834913.v1
title: Additional file 23 of Comparative transcriptome analysis of inbred lines and contrasting hybrids reveals overdominance mediate early biomass vigor in hybrid cotton

description: Additional file 23. Information of overdominant genes those were unique and common among comparisons of high, medium and low hybrids in root and leaf
DOI: 10.6084/m9.figshare.7116233.v1
title: Additional file 1: of Genome-wide analysis of long non-coding RNAs in Catalpa bungei and their potential function in floral transition using high-throughput sequencing

description: Table S1. List of the floral transition genes in C. bungei. (XLSX 1035 kb)
DOI: 10.6084/m9.figshare.11834826.v1
title: Additional file 11 of Comparative transcriptome analysis of inbred lines and contrasting hybrids reveals overdominance mediate early biomass vigor in hybrid cotton

description: Additional file 11. Enriched GO terms of overdominant genes in root of high hybrid-parent triad
DOI: 10.6084/m9.figshare.11834934.v1
title: Additional file 6 of Genome-wide identification of MAPKKK genes and their responses to phytoplasma infection in Chinese jujube (Ziziphus jujuba Mill.)

description: Additional file 6: Table S2. Primer sequences of ZjMAPKKKs for qRT-PCR.
DOI: 10.6084/m9.figshare.11834961
title: Additional file 3 of Comparative transcriptome analysis of inbred lines and contrasting hybrids reveals overdominance mediate early biomass vigor in hybrid cotton

description: Additional file 3. Information on DEGs in leaf of high hybrid-parent triad
DOI: 10.6084/m9.figshare.11835216
title: Additional file 2 of Construction of a circRNA-miRNA-mRNA network based on competitive endogenous RNA reveals the function of circRNAs in osteosarcoma

description: Additional file 2: Table S1. Five hundred and three miRNAs predicted to target these 14 circRNAs.
DOI: 10.6084/m9.figshare.11834838.v1
title: Additional file 12 of Comparative transcriptome analysis of inbred lines and contrasting hybrids reveals overdominance mediate early biomass vigor in hybrid cotton

description: Additional file 12. Enriched KEGG terms of overdominant genes in root of high hybrid-parent triad