cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.15468/dl.dqp6qd
title: Occurrence Download

description: A dataset containing 2762 species occurrences available in GBIF matching the query:
{
 "and" : [
 "BasisOfRecord is one of (Observation, Machine Observation, Human Observation, Material sample, Specimen, Living Specimen, Occurrence evidence)",
 "Continent is Asia",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 "TaxonKey is Stemonuraceae"
 ]
}

 The dataset includes 2762 records from 62 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0014620-250426092105405/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.kqwc3h
title: Occurrence Download

description: A dataset containing 92 species occurrences available in GBIF matching the query:
{
 "and" : [
 "BasisOfRecord is one of (Observation, Machine Observation, Human Observation, Material sample, Specimen, Living Specimen, Occurrence evidence)",
 "Continent is Asia",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 "TaxonKey is Sladeniaceae"
 ]
}

 The dataset includes 92 records from 18 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0014622-250426092105405/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.6084/m9.figshare.28927406
title: Frp-混凝土粘结数据

description: Frp-混凝土粘结数据
DOI: 10.15468/dl.dbt3j6
title: Occurrence Download

description: A dataset containing 8 species occurrences available in GBIF matching the query:
{
 "and" : [
 "CoordinateUncertaintyInMeters 0.0-250.0",
 "Geometry POLYGON((46.22816 54.46608,55.42342 54.46608,55.42342 56.61445,46.22816 56.61445,46.22816 54.46608))",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "TaxonKey is Ricciocarpos natans (L.) Corda"
 ]
}

 The dataset includes 8 records from 2 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0014623-250426092105405/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.nrqhj7
title: Occurrence Download

description: A dataset containing 930 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Bombus atratus Franklin, 1913"
 ]
}

 The dataset includes 930 records from 23 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0014624-250426092105405/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.34740/kaggle/dsv/11670823
title: Hacker News Cumulative Data
DOI: 10.15468/dl.hmgbtd
title: Occurrence Download

description: A dataset containing 61 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is Spain",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "TaxonKey is Dalatias licha (Bonnaterre, 1788)"
 ]
}

 The dataset includes 61 records from 6 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0014625-250426092105405/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.5281/zenodo.15076570
title: Development and evaluation of nanobody tracers for noninvasive nuclear imaging of the immune-checkpoint TIGIT

description: Introduction: T cell Ig and ITIM domain receptor (TIGIT) is a next-generation immune checkpoint predominantly expressed on activated T cells and NK cells, exhibiting an unfavorable prognostic association with various malignancies. Despite the emergence of multiple TIGIT-blocking agents entering clinical trials, only a fraction of patients responded positively to anti-TIGIT therapy. Consequently, an urgent demand arises for noninvasive techniques to quantify and monitor TIGIT expression, facilitating patient stratification and enhancing therapeutic outcomes. Small antigen binding moieties such as nanobodies, are promising candidates for such tracer development.

Methods: We generated a panel of anti-human or anti-mouse TIGIT nanobodies from immunized llamas. In addition, we designed a single-chain variable fragment derived from the clinically tested monoclonal antibody Vibostolimab targeting TIGIT, and assessed its performance alongside the nanobodies. In vitro characterization studies were performed, including binding ability and affinity to cell expressed or recombinant TIGIT. After Technetium-99m labeling, the nanobodies and the single-chain variable fragment were evaluated in vivo for their ability to detect TIGIT expression using SPECT/CT imaging, followed by ex vivo biodistribution analysis.

Results: Nine nanobodies were selected for binding to recombinant and cell expressed TIGIT with low sub-nanomolar affinities and are thermostable. A six-fold higher uptake in TIGIT-overexpressing tumor was demonstrated one hour post- injection with Technetium-99m labeled nanobodies compared to an irrelevant control nanobody. Though the single-chain variable fragment exhibited superior binding to TIGIT-expressing peripheral blood mononuclear cells in vitro, its in vivo behavior yielded lower tumor-to-background ratios at one hour post- injection, indicating that nanobodies are better suited for in vivo imaging than the single-chain variable fragment. Despite the good affinity, high specificity and on-target uptake in mice in this setting, imaging of TIGIT expression on tumor- infiltrating lymphocytes within MC38 tumors remained elusive. This is likely due to the low expression levels of TIGIT in this model.

Discussion: The excellent affinity, high specificity and rapid on-target uptake in mice bearing TIGIT- overexpressing tumors showed the promising diagnostic potential of nanobodies to noninvasively image high TIGIT expression within the tumor. These findings hold promise for clinical translation to aid patient selection and improve therapy response.
DOI: 10.5281/zenodo.15076571
title: Development and evaluation of nanobody tracers for noninvasive nuclear imaging of the immune-checkpoint TIGIT

description: Introduction: T cell Ig and ITIM domain receptor (TIGIT) is a next-generation immune checkpoint predominantly expressed on activated T cells and NK cells, exhibiting an unfavorable prognostic association with various malignancies. Despite the emergence of multiple TIGIT-blocking agents entering clinical trials, only a fraction of patients responded positively to anti-TIGIT therapy. Consequently, an urgent demand arises for noninvasive techniques to quantify and monitor TIGIT expression, facilitating patient stratification and enhancing therapeutic outcomes. Small antigen binding moieties such as nanobodies, are promising candidates for such tracer development.

Methods: We generated a panel of anti-human or anti-mouse TIGIT nanobodies from immunized llamas. In addition, we designed a single-chain variable fragment derived from the clinically tested monoclonal antibody Vibostolimab targeting TIGIT, and assessed its performance alongside the nanobodies. In vitro characterization studies were performed, including binding ability and affinity to cell expressed or recombinant TIGIT. After Technetium-99m labeling, the nanobodies and the single-chain variable fragment were evaluated in vivo for their ability to detect TIGIT expression using SPECT/CT imaging, followed by ex vivo biodistribution analysis.

Results: Nine nanobodies were selected for binding to recombinant and cell expressed TIGIT with low sub-nanomolar affinities and are thermostable. A six-fold higher uptake in TIGIT-overexpressing tumor was demonstrated one hour post- injection with Technetium-99m labeled nanobodies compared to an irrelevant control nanobody. Though the single-chain variable fragment exhibited superior binding to TIGIT-expressing peripheral blood mononuclear cells in vitro, its in vivo behavior yielded lower tumor-to-background ratios at one hour post- injection, indicating that nanobodies are better suited for in vivo imaging than the single-chain variable fragment. Despite the good affinity, high specificity and on-target uptake in mice in this setting, imaging of TIGIT expression on tumor- infiltrating lymphocytes within MC38 tumors remained elusive. This is likely due to the low expression levels of TIGIT in this model.

Discussion: The excellent affinity, high specificity and rapid on-target uptake in mice bearing TIGIT- overexpressing tumors showed the promising diagnostic potential of nanobodies to noninvasively image high TIGIT expression within the tumor. These findings hold promise for clinical translation to aid patient selection and improve therapy response.
DOI: 10.5281/zenodo.15335856
title: NBA Clutch Defense Raw Data

description: This dataset contains 24 spreadsheets covering NBA seasons from 2000–01 to 2023–24. Each spreadsheet includes three tabs: (1) top 50 players by clutch minutes with their clutch-time defensive statistics, (2) all NBA players' regular season defensive statistics, and (3) a comparison sheet with key standardized defensive metrics. All values have been adjusted to per-36-minute rates to ensure comparability across players and contexts. This dataset was used to analyze changes in defensive performance during clutch situations.
DOI: 10.5281/zenodo.15335857
title: NBA Clutch Defense Raw Data

description: This dataset contains 24 spreadsheets covering NBA seasons from 2000–01 to 2023–24. Each spreadsheet includes three tabs: (1) top 50 players by clutch minutes with their clutch-time defensive statistics, (2) all NBA players' regular season defensive statistics, and (3) a comparison sheet with key standardized defensive metrics. All values have been adjusted to per-36-minute rates to ensure comparability across players and contexts. This dataset was used to analyze changes in defensive performance during clutch situations.
DOI: 10.15468/dl.z3nt3w
title: Occurrence Download

description: A dataset containing 171714 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Glycine max (L.) Merr."
 ]
}

 The dataset includes 171714 records from 538 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0014609-250426092105405/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.d5bvq2
title: Occurrence Download

description: A dataset containing 2 species occurrences available in GBIF matching the query:
{
 "and" : [
 "CoordinateUncertaintyInMeters 0.0-250.0",
 "Geometry POLYGON((46.38082 54.50964,55.28113 54.50964,55.28113 56.63688,46.38082 56.63688,46.38082 54.50964))",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "TaxonKey is Salicornia perennans Willd."
 ]
}

 The dataset includes 2 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0014627-250426092105405/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.5281/zenodo.15335865
title: CAPM's Effectiveness in Predicting Returns in the Indian Stock Market
DOI: 10.5281/zenodo.15335866
title: CAPM's Effectiveness in Predicting Returns in the Indian Stock Market
DOI: 10.5281/zenodo.15335846
title: Optimizing antibody PET imaging: a comparative preclinical analysis of nanobody and minibody-like PET tracers

description: Purpose

Positron emission tomography remains the most important medical imaging technique for noninvasive imaging. Advances in radiotracer design, particularly those based on antibody(-formats), have broadened diagnostic applications. While minibodies and nanobodies stand out among antibody-type radiotracers due to their unique characteristics and pharmacokinetics, a direct comparison between these formats remains unexplored. In this study, we generated a so-called minabody, a minibody-like protein consisting of a nanobody fused to a CH3 domain, and compared it with its nanobody counterpart in vitro and in vivo upon labeling with various PET radionuclides.

Methods

A previously developed human TIGIT-targeting nanobody was reformatted to a minabody format to allow head-to-head comparison of both formats. The minabody and nanobody formats were compared in vitro for binding, specificity and stability. The minabody and/or nanobody formats were labeled with copper-64, gallium-68 or fluor-18 for non-invasive imaging of human TIGIT-expressing tumors by PET/CT over time.

Results

The minabody format showed higher binding affinities compared to the nanobody format. Despite lower binding affinity, the nanobody format outperformed the minabody format as PET imaging tracer showing higher specificity and allowing imaging of human TIGIT expression from 1 to 48 h post-injection upon labeling with copper-64. In addition, copper-64 showed superior tumor uptake and contrast for nanobody imaging compared to gallium-68 and fluor-18.

Conclusion

This study describes the first head-to-head comparison between the minibody and nanobody format for PET imaging. Our results underscore the importance of considering both targeting vector format and the radionuclide to achieve accurate and high-quality PET imaging.
DOI: 10.5281/zenodo.15335847
title: Optimizing antibody PET imaging: a comparative preclinical analysis of nanobody and minibody-like PET tracers

description: Purpose

Positron emission tomography remains the most important medical imaging technique for noninvasive imaging. Advances in radiotracer design, particularly those based on antibody(-formats), have broadened diagnostic applications. While minibodies and nanobodies stand out among antibody-type radiotracers due to their unique characteristics and pharmacokinetics, a direct comparison between these formats remains unexplored. In this study, we generated a so-called minabody, a minibody-like protein consisting of a nanobody fused to a CH3 domain, and compared it with its nanobody counterpart in vitro and in vivo upon labeling with various PET radionuclides.

Methods

A previously developed human TIGIT-targeting nanobody was reformatted to a minabody format to allow head-to-head comparison of both formats. The minabody and nanobody formats were compared in vitro for binding, specificity and stability. The minabody and/or nanobody formats were labeled with copper-64, gallium-68 or fluor-18 for non-invasive imaging of human TIGIT-expressing tumors by PET/CT over time.

Results

The minabody format showed higher binding affinities compared to the nanobody format. Despite lower binding affinity, the nanobody format outperformed the minabody format as PET imaging tracer showing higher specificity and allowing imaging of human TIGIT expression from 1 to 48 h post-injection upon labeling with copper-64. In addition, copper-64 showed superior tumor uptake and contrast for nanobody imaging compared to gallium-68 and fluor-18.

Conclusion

This study describes the first head-to-head comparison between the minibody and nanobody format for PET imaging. Our results underscore the importance of considering both targeting vector format and the radionuclide to achieve accurate and high-quality PET imaging.
DOI: 10.17605/osf.io/h3pyd
title: Data
DOI: 10.15468/dl.8pmdyx
title: Occurrence Download

description: A dataset containing 112163 species occurrences available in GBIF matching the query:
{
 "and" : [
 "HasGeospatialIssue is false",
 "HasCoordinate is true",
 "OccurrenceStatus is Present",
 {
 "not" : {
 "BasisOfRecord" : [
 "is one of (Fossil, Living Specimen)"
 ]
 }
 },
 "TaxonKey is Chamaecrista Moench"
 ]
}

 The dataset includes 112163 records from 774 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0014621-250426092105405/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.wyf7h2
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{"type":"and","predicates":[{"type":"equals","key":"GADM_LEVEL_2_GID","value":"TUR.41.14_1","matchCase":false},{"type":"equals","key":"CLASS_KEY","value":"212","matchCase":false},{"type":"greaterThanOrEquals","key":"YEAR","value":"2015","matchCase":false},{"type":"not","predicate":{"type":"in","key":"BASIS_OF_RECORD","values":["MATERIAL_CITATION","MATERIAL_SAMPLE","PRESERVED_SPECIMEN"],"matchCase":false}},{"type":"lessThanOrEquals","key":"COORDINATE_UNCERTAINTY_IN_METERS","value":"10000","matchCase":false},{"type":"equals","key":"LICENSE","value":"CC BY 4.0","matchCase":false}]}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0006982-260108223611665/datasets/export for details.
DOI: 10.15468/dl.w8j2yq
title: Occurrence Download

description: A dataset containing 902 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Sceloporus gadoviae"
 ]
}

 The dataset includes 902 records from 44 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0006981-260108223611665/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.pzj3qg
title: Occurrence Download

description: A dataset containing 153 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Pseudalsophis elegans (Tschudi, 1845)"
 ]
}

 The dataset includes 153 records from 26 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0010037-250515123054153/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.17632/98rhrf6s72.1
title: Dataset for master thesis

description: Panel contains financial statement data of Russian public non-financial companies and also their annual dividend announcements. Precise description of dataset is presented on special sheet of the file.
DOI: 10.17632/fvmy5mb7hk.1
title: Tidal wetland historical change by habitat class, Oregon coast, USA from 1800s to 2019

description: How have tidal wetlands on the Oregon coast, USA changed over the past 150 years? We mapped and quantified a striking and previously unrecognized coastwide alteration: the near-eradication of once-prevalent tidal forested wetlands (TFWs). We argue that this finding calls for a paradigm shift in management of Oregon’s outer coast estuaries. By combining elevation-based estuary maps and historical (1800s) vegetation data, we found that TFWs made up a majority (54%) of the coast's historical tidal wetland area, while emergent tidal wetlands ("tidal marsh") occupied a smaller area (42%). However, diking and vegetation conversion resulted in the loss of 95% of historical TFW, compared to 59% of historical tidal marsh. Tidal marsh loss was offset by a gain of 1770 ha of tidal marsh through progradation, but no similar gain occurred for TFW. The extreme loss of TFW has most likely reduced the provision of key TFW ecosystem services, such as carbon sequestration and complex, productive salmonid habitat. Restoring TFW is a high priority and can help re-establish these habitats and ecosystem services, benefiting coastal economies and ecosystems. Further research is needed to identify restoration sites with environmental conditions suitable for the establishment and long-term persistence of TFW. Identification and prioritization of potential restoration sites should account for climate change and emphasize the availability of landward migration areas and other landscape setting factors that could affect long-term persistence of TFW.
DOI: 10.17632/fvmy5mb7hk.2
title: Tidal wetland historical change by habitat class, Oregon coast, USA from 1800s to 2019

description: How have tidal wetlands on the Oregon coast, USA changed over the past 150-200 years? We mapped and quantified a striking and previously unrecognized coastwide alteration: the near-eradication of once-prevalent tidal forested wetlands (TFWs). We argue that this finding calls for a paradigm shift in management of Oregon’s outer coast estuaries. By combining elevation-based estuary maps and historical (1800s) vegetation data, we found that TFWs made up a majority (54%) of the coast's historical tidal wetland area, while emergent tidal wetlands ("tidal marsh") occupied a smaller area (42%). However, diking and vegetation conversion resulted in the loss of 95% of historical TFW, compared to 59% of historical tidal marsh. Tidal marsh loss was offset by a gain of 1770 ha of tidal marsh through progradation, but no similar gain occurred for TFW. The extreme loss of TFW has most likely reduced the provision of key TFW ecosystem services, such as carbon sequestration and complex, productive salmonid habitat. Restoring TFW is a high priority and can help re-establish these habitats and ecosystem services, benefiting coastal economies and ecosystems. Further research is needed to identify restoration sites with environmental conditions suitable for the establishment and long-term persistence of TFW. Identification and prioritization of potential restoration sites should account for climate change and emphasize the availability of landward migration areas and other landscape setting factors that could affect long-term persistence of TFW.
DOI: 10.15468/dl.w28qdn
title: Occurrence Download

description: A dataset listing the 576 species recorded in GBIF matching the query:
{
 "and" : [
 "EstablishmentMeans is one of (native, nativeReintroduced)",
 "GadmGid is USA.5.1_1",
 "OccurrenceStatus is Present"
 ]
}

 The dataset's 576 records were derived from 32 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0009452-250415084134356/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.17632/jprxshtr4t.1
title: Machine vision-based multiple width measurements for agricultural produce - Original and multiple width measurements images

description: The attached MS PowerPoint presentation contains the original image data that was used in the analysis of the manuscript “Machine vision-based multiple width measurements for agricultural produce.” The image data contains (1) original images of agricultural produce (food product, vegetables, and fruits), (2) labeled binary images showing the measured multiple widths, and (3) a sample of plotted multiple widths showing the profile. The top and bottom end caps are set to cover the main body of the object, ignoring the pedicle. The individual image title includes the common name of the produce and the DPI (image resolution).
DOI: 10.17632/jy8bdmf7yz.1
title: Data for: Survivability and pathways of amino acids in oceanic hydrothermal systems

description: Raw data for figures in the manuscript by Aspin et al. "Survivability and pathways of amino acids in oceanic hydrothermal systems"