cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.19114355
title: Supplementary Material for: Neonatal Screening for Congenital Adrenal Hyperplasia in Denmark: 10 Years of Experience

description: Introduction: Early detection of salt-wasting congenital adrenal hyperplasia (SW-CAH) is important to reduce CAH related morbidity. However, neonatal screening has shown to have a low positive predictive value (PPV), especially among preterm newborns. Here, the Danish CAH screening is evaluated by comparing incidence and morbidity of SW-CAH ten years before and after introduction of screening. Furthermore, sensitivity, specificity and PPV are determined. Methods: All newborns in Denmark born during 1999-2018 and diagnosed with SW-CAH were identified in the Danish National Patient Registry and/or at the Department of Clinical Genetics, Rigshospitalet. Newborns with a positive neonatal CAH screening were identified at Statens Serum Institut. Correct diagnosis was evaluated by medical record review. Results: A total of 65 newborns with SW-CAH were identified. The incidence of SW-CAH was 5:100,000 both before and after introduction of screening. Performance of sensitivity and specificity of the screening were 97% and 100%, respectively, and the PPV was 55% for the given period. Stratified according to gestational age, the PPV was 33% and 61% for pre -and fullterm newborns, respectively. Though not significant the proportion of newborns presenting with salt-wasting crisis decreased after introduction of screening from 29% vs. 10% (p=0.07). Discussion and Conclusion: Neonatal screening for SW-CAH has not led to an increase in the incidence of newborns diagnosed with SW-CAH. The screening algorithm has effectively identified newborns with SW-CAH. After 2009, there was a tendency towards a lower proportion of newborns with salt-wasting crisis at diagnosis. Finally, the study emphasizes the benefits of using second-tier screening as well as repeated screening of premature newborns.
DOI: 10.6084/m9.figshare.19145579
title: Supplementary Material for: Alterations in the Stool Microbiome in Newborns undergoing Mild Therapeutic Hypothermia after Hypoxic-Ischemic Encephalopathy

description: Background: Hypoxic-ischemic encephalopathy (HIE) is associated with brain injury in newborns, and may lead to disability or death. Mild therapeutic hypothermia (TH) is an effective neuroprotective intervention and an established standard of care in western countries. The gut microbiome, the genomic and physico-chemical contribution of the gut microbiota, serves important functions and is increasingly recognised as a major influencer on development. The impact of HIE and TH on the evolving gut microbiota of the newborn remains to be elucidated. Objective: To carry out an exploratory study on the effects of HIE and TH on the gut microbiome in term neonates. Methods and Results: Stool samples were obtained from 28 newborns with HIE (median age 68 h) undergoing TH on the neonatal unit (HIE TH group), with a follow-on stool sample available for 20 of these babies (median age 151 h). For comparison, a single stool specimen was obtained from 19 healthy newborns on the postnatal ward (median age 34 h). The microbiota composition was determined using established microbial DNA extraction and 16S rRNA gene sequencing methodology. There was no difference in the mode of delivery or the method of feeding the newborns, once established, between the two groups. All the infants in the HIE TH group had received antibiotics compared to only one of the controls. A lower -diversity, quantified by the Shannon diversity index, was noted in the microbiota of the HIE TH group in comparison to the control group. The HIE TH group had a higher mean relative abundance (MRA) of facultative anaerobes and aerobes such as Staphylococcus species and a lower MRA of strict anaerobes, such as members of the Bacteroides genus, compared to the control. Also, there was a significant reduction in the MRA of the genus Bifidobacterium in the HIE TH group. Although the mode of delivery exerts a profound influence on the gut microbiota of the newborn, distance-based redundancy analysis showed that TH may exert an independent influence. This study could not determine the independent contribution of the use of antibiotics or the NICU environment. Conclusion: In this study we demonstrate an alteration in the microbiota composition in newborns undergoing TH for HIE. (359 words)
DOI: 10.6084/m9.figshare.19145579.v1
title: Supplementary Material for: Alterations in the Stool Microbiome in Newborns undergoing Mild Therapeutic Hypothermia after Hypoxic-Ischemic Encephalopathy

description: Background: Hypoxic-ischemic encephalopathy (HIE) is associated with brain injury in newborns, and may lead to disability or death. Mild therapeutic hypothermia (TH) is an effective neuroprotective intervention and an established standard of care in western countries. The gut microbiome, the genomic and physico-chemical contribution of the gut microbiota, serves important functions and is increasingly recognised as a major influencer on development. The impact of HIE and TH on the evolving gut microbiota of the newborn remains to be elucidated. Objective: To carry out an exploratory study on the effects of HIE and TH on the gut microbiome in term neonates. Methods and Results: Stool samples were obtained from 28 newborns with HIE (median age 68 h) undergoing TH on the neonatal unit (HIE TH group), with a follow-on stool sample available for 20 of these babies (median age 151 h). For comparison, a single stool specimen was obtained from 19 healthy newborns on the postnatal ward (median age 34 h). The microbiota composition was determined using established microbial DNA extraction and 16S rRNA gene sequencing methodology. There was no difference in the mode of delivery or the method of feeding the newborns, once established, between the two groups. All the infants in the HIE TH group had received antibiotics compared to only one of the controls. A lower -diversity, quantified by the Shannon diversity index, was noted in the microbiota of the HIE TH group in comparison to the control group. The HIE TH group had a higher mean relative abundance (MRA) of facultative anaerobes and aerobes such as Staphylococcus species and a lower MRA of strict anaerobes, such as members of the Bacteroides genus, compared to the control. Also, there was a significant reduction in the MRA of the genus Bifidobacterium in the HIE TH group. Although the mode of delivery exerts a profound influence on the gut microbiota of the newborn, distance-based redundancy analysis showed that TH may exert an independent influence. This study could not determine the independent contribution of the use of antibiotics or the NICU environment. Conclusion: In this study we demonstrate an alteration in the microbiota composition in newborns undergoing TH for HIE. (359 words)
DOI: 10.34820/fk2/jmnhlq/ebmcyf
title: clean dataset opinion segmentation about vaccine.tab

description: :unav
DOI: 10.34820/fk2/jmnhlq
title: vaccine segmentation

description: dataset about vaccine opinion in Indonesia with several attributes
DOI: 10.6084/m9.figshare.19493912
title: Supplementary Material for: The Italian Version of the Severe Respiratory Insufficiency Questionnaire

description: <b><i>Background:</i></b> The Severe Respiratory Insufficiency Questionnaire (SRI) is a multidimensional instrument for health-related quality of life (HRQL) assessment in patients with chronic respiratory failure (CRF). The SRI has originally been developed in German in 2003, but 15 translated versions have been created during the last 18 years with the exclusion of the Italian translation. <b><i>Aims of the Study:</i></b> The present project was aimed at creating an Italian version of the SRI. <b><i>Methods:</i></b> Professional forward-translation and back-translation procedures have been provided based on the original German version by independent translators, and this was followed by final reconciliation. <b><i>Results:</i></b> The Italian SRI contains 49 items covering 7 different subscales which can summarize to one Summary Score. <b><i>Conclusions:</i></b> The Italian SRI is a multidimensional instrument, which can be used for HRQL assessment in Italian-speaking patients with CRF. Validation of the Italian version of the questionnaire is formally required in the future.
DOI: 10.6084/m9.figshare.19493912.v1
title: Supplementary Material for: The Italian Version of the Severe Respiratory Insufficiency Questionnaire

description: <b><i>Background:</i></b> The Severe Respiratory Insufficiency Questionnaire (SRI) is a multidimensional instrument for health-related quality of life (HRQL) assessment in patients with chronic respiratory failure (CRF). The SRI has originally been developed in German in 2003, but 15 translated versions have been created during the last 18 years with the exclusion of the Italian translation. <b><i>Aims of the Study:</i></b> The present project was aimed at creating an Italian version of the SRI. <b><i>Methods:</i></b> Professional forward-translation and back-translation procedures have been provided based on the original German version by independent translators, and this was followed by final reconciliation. <b><i>Results:</i></b> The Italian SRI contains 49 items covering 7 different subscales which can summarize to one Summary Score. <b><i>Conclusions:</i></b> The Italian SRI is a multidimensional instrument, which can be used for HRQL assessment in Italian-speaking patients with CRF. Validation of the Italian version of the questionnaire is formally required in the future.
DOI: 10.6084/m9.figshare.19493831
title: Supplementary Material for: Lipidomic Profiling of Bronchoalveolar Lavage Fluid Extracellular Vesicles Indicates Their Involvement in Lipopolysaccharide-Induced Acute Lung Injury

description: Emerging data support the pivotal role of extracellular vesicles (EVs) in normal cellular physiology and disease conditions. However, despite their abundance, there is much less information about the lipid mediators carried in EVs, especially in the context of acute lung injury (ALI). Our data demonstrate that C57BL/6 mice subjected to intranasal <i>Escherichia coli</i> lipopolysaccharide (LPS)-induced ALI release, a higher number of EVs into the alveolar space, compared to saline-treated controls. EVs released during ALI originated from alveolar epithelial cells, macrophages, and neutrophils and carry a diverse array of lipid mediators derived from ω-3 and ω-6 polyunsaturated fatty acids (PUFA). The eicosanoids in EVs correlated with cellular levels of arachidonic acid, expression of cytosolic phospholipase A2, cyclooxygenase (COX), lipoxygenase (LOX), and cytochrome epoxygenase p450 proteins in pulmonary macrophages. Furthermore, EVs from LPS-toll-like receptor 4 knockout (TLR4<sup>-/-</sup>) mice contained significantly lower amounts of COX and LOX catalyzed eicosanoids and ω-3 PUFA metabolites. More importantly, EVs from LPS-treated wild-type mice increased TNF-α release by macrophages and reduced alveolar epithelial monolayer barrier integrity compared to EVs from LPS-treated TLR4<sup>−/−</sup> mice. In summary, our study demonstrates for the first time that the EV carried PUFA metabolite profile in part depends on the inflammatory status of the lung macrophages and modulates pulmonary macrophage and alveolar epithelial cell function during LPS-induced ALI.
DOI: 10.5517/ccdc.csd.cc27b4wm
title: CCDC 2065340: Experimental Crystal Structure Determination

description: Related Article: Orçun Balkaner, Derya Işıl Sarıoğulları, Aylin Uslu|2022|J.Mol.Struct.|1261|132834|doi:10.1016/j.molstruc.2022.132834
DOI: 10.5517/ccdc.csd.cc27b4xn
title: CCDC 2065341: Experimental Crystal Structure Determination

description: Related Article: Orçun Balkaner, Derya Işıl Sarıoğulları, Aylin Uslu|2022|J.Mol.Struct.|1261|132834|doi:10.1016/j.molstruc.2022.132834
DOI: 10.5517/ccdc.csd.cc27b4yp
title: CCDC 2065342: Experimental Crystal Structure Determination

description: Related Article: Orçun Balkaner, Derya Işıl Sarıoğulları, Aylin Uslu|2022|J.Mol.Struct.|1261|132834|doi:10.1016/j.molstruc.2022.132834
DOI: 10.5517/ccdc.csd.cc27b4zq
title: CCDC 2065343: Experimental Crystal Structure Determination

description: Related Article: Orçun Balkaner, Derya Işıl Sarıoğulları, Aylin Uslu|2022|J.Mol.Struct.|1261|132834|doi:10.1016/j.molstruc.2022.132834
DOI: 10.5517/ccdc.csd.cc28b6nh
title: CCDC 2095186: Experimental Crystal Structure Determination

description: Related Article: Tatyana N. Moshkina, Emiliya V. Nosova, Alexandra E. Kopotilova, Maria I. Savchuk, Igor L. Nikonov, Dmitry S. Kopchuk, Pavel A. Slepukhin, Grigory A. Kim, Galina N. Lipunova, Valery N. Charushin|2022|J.Photochem.Photobiol.A:Chem.|429|113917|doi:10.1016/j.jphotochem.2022.113917
DOI: 10.5517/ccdc.csd.cc28fhpx
title: CCDC 2098349: Experimental Crystal Structure Determination

description: Related Article: Yan-Hua Wen, Tian-Jiao Chen, Long-Yu Jiang, Li Li, Mengbo Guo, Yu Peng, Jing-Jing Chen, Fei Pei, Jin-Ling Yang, Rui-Shan Wang, Ting Gong, Ping Zhu|2022|iScience|25|104030|doi:10.1016/j.isci.2022.104030
DOI: 10.5517/ccdc.csd.cc299ljr
title: CCDC 2124384: Experimental Crystal Structure Determination

description: Related Article: Lily Southcott, Jennifer N. Whetter, Luke Wharton, Brian O. Patrick, Kristof Zarschler, Manja Kubeil, Holger Stephan, María de Guadalupe Jaraquemada-Peláez, Chris Orvig|2022|J.Inorg.Biochem.|231|111789|doi:10.1016/j.jinorgbio.2022.111789
DOI: 10.5517/ccdc.csd.cc299lks
title: CCDC 2124385: Experimental Crystal Structure Determination

description: Related Article: Lily Southcott, Jennifer N. Whetter, Luke Wharton, Brian O. Patrick, Kristof Zarschler, Manja Kubeil, Holger Stephan, María de Guadalupe Jaraquemada-Peláez, Chris Orvig|2022|J.Inorg.Biochem.|231|111789|doi:10.1016/j.jinorgbio.2022.111789
DOI: 10.5517/ccdc.csd.cc29fxl8
title: CCDC 2128540: Experimental Crystal Structure Determination

description: Related Article: Ebru Koçak Aslan, Vagolu Siva Krishna, Sanja J. Armaković, Stevan Armaković, Onur Şahin, Tone Tønjum, Miyase Gözde Gündüz|2022|J.Mol.Liq.|354|118873|doi:10.1016/j.molliq.2022.118873
DOI: 10.5517/ccdc.csd.cc29fxth
title: CCDC 2128547: Experimental Crystal Structure Determination

description: Related Article: Cai-Yong Zhu, Cui-Li Wang, Le Chen, Wei Gao, Peng Li, Xiu-Mei Zhang|2022|J.Solid State Chem.|310|123079|doi:10.1016/j.jssc.2022.123079
DOI: 10.5517/ccdc.csd.cc29y9wg
title: CCDC 2143336: Experimental Crystal Structure Determination

description: Related Article: Yahui Li, Jingwen Liu, Yingchun Wu, Yiming Li, Fujiang Guo|2022|Phytochemistry|198|113164|doi:10.1016/j.phytochem.2022.113164
DOI: 10.5517/ccdc.csd.cc29y9zk
title: CCDC 2143339: Experimental Crystal Structure Determination

description: Related Article: Yahui Li, Jingwen Liu, Yingchun Wu, Yiming Li, Fujiang Guo|2022|Phytochemistry|198|113164|doi:10.1016/j.phytochem.2022.113164
DOI: 10.5517/ccdc.csd.cc29yd5v
title: CCDC 2143407: Experimental Crystal Structure Determination

description: Related Article: Yahui Li, Jingwen Liu, Yingchun Wu, Yiming Li, Fujiang Guo|2022|Phytochemistry|198|113164|doi:10.1016/j.phytochem.2022.113164
DOI: 10.5517/ccdc.csd.cc29yd4t
title: CCDC 2143406: Experimental Crystal Structure Determination

description: Related Article: Yahui Li, Jingwen Liu, Yingchun Wu, Yiming Li, Fujiang Guo|2022|Phytochemistry|198|113164|doi:10.1016/j.phytochem.2022.113164
DOI: 10.5517/ccdc.csd.cc29yd6w
title: CCDC 2143408: Experimental Crystal Structure Determination

description: Related Article: Yahui Li, Jingwen Liu, Yingchun Wu, Yiming Li, Fujiang Guo|2022|Phytochemistry|198|113164|doi:10.1016/j.phytochem.2022.113164
DOI: 10.6084/m9.figshare.19448264.v1
title: Gosselin_Stat_Immunoblot

description: This is the dataset associated with a scoping review that aimed at providing a first overview of statistical methods used in biochemical research involving immunoblotting (also referred to as western blotting), a technique frequently used to quantify proteins of interest. A reverse chronological systematic sampling was implemented to explore the PubMed online browser and analyse 2932 experimental conditions (i.e. experimental groups) in quantitative immunoblots from 64 articles published at the end of 2021. The statistical test (actual study size n = 67) and software (actual study size n = 61) used for each article and the sample size for each experimental condition were documented.
DOI: 10.6084/m9.figshare.19448264
title: Gosselin_Stat_Immunoblot

description: This is the dataset associated with a scoping review that aimed at providing a first overview of statistical methods used in biochemical research involving immunoblotting (also referred to as western blotting), a technique frequently used to quantify proteins of interest. A reverse chronological systematic sampling was implemented to explore the PubMed online browser and analyse 2932 experimental conditions (i.e. experimental groups) in quantitative immunoblots from 64 articles published at the end of 2021. The statistical test (actual study size n = 67) and software (actual study size n = 61) used for each article and the sample size for each experimental condition were documented.
DOI: 10.6084/m9.figshare.19493945
title: source data.zip

description: <b>Activating lattice oxygen in NiFe-based (oxy)hydroxide for water electrolysis</b>
DOI: 10.6084/m9.figshare.19221270
title: Supplementary Material for: Impact Of Post-Transplantation Hypomagnesemia On Long-Term Graft And Patient Survival After Transplantation

description: BACKGROUND: Post-transplant hypomagnesemia is commonly observed among patients prescribed CNIs. METHODS: We conducted a retrospective single center analysis (2000-2013, N=726) to examine the association of hypomagnesemia with long-term patient and allograft outcomes in kidney transplant recipients. A median serum magnesium level of all measured magnesium levels from 1 month to 1 year post-transplant was calculated. RESULTS: For every increase in Mg of 0.1 mg/dL, the risk for either graft loss or death, overall survival and death with a functioning graft increased by 11%, 14% and 12% respectively (p &lt; 0.01). In a multivariate model, patients with median Mg level ≥ 1.7 mg/dL had a reduced overall survival rate (HR 1.57, 95% CI 1.04-2.38, p = 0.033) compared to those with median Mg level &lt; 1.7 mg/dL. This association was observed in subgroups of patients above 60 years old, in those who had a slow graft function (SGF) and in females. CONCLUSIONS: Post-transplant hypomagnesemia is associated with better patient and allograft survival up to 10 years post-transplant. This relationship remained significant after accounting for baseline allograft function, presence of slow graft function (SGF) and CNI trough levels.
DOI: 10.6084/m9.figshare.19221270.v1
title: Supplementary Material for: Impact Of Post-Transplantation Hypomagnesemia On Long-Term Graft And Patient Survival After Transplantation

description: BACKGROUND: Post-transplant hypomagnesemia is commonly observed among patients prescribed CNIs. METHODS: We conducted a retrospective single center analysis (2000-2013, N=726) to examine the association of hypomagnesemia with long-term patient and allograft outcomes in kidney transplant recipients. A median serum magnesium level of all measured magnesium levels from 1 month to 1 year post-transplant was calculated. RESULTS: For every increase in Mg of 0.1 mg/dL, the risk for either graft loss or death, overall survival and death with a functioning graft increased by 11%, 14% and 12% respectively (p &lt; 0.01). In a multivariate model, patients with median Mg level ≥ 1.7 mg/dL had a reduced overall survival rate (HR 1.57, 95% CI 1.04-2.38, p = 0.033) compared to those with median Mg level &lt; 1.7 mg/dL. This association was observed in subgroups of patients above 60 years old, in those who had a slow graft function (SGF) and in females. CONCLUSIONS: Post-transplant hypomagnesemia is associated with better patient and allograft survival up to 10 years post-transplant. This relationship remained significant after accounting for baseline allograft function, presence of slow graft function (SGF) and CNI trough levels.
DOI: 10.5281/zenodo.6405396
title: The HistLight global lightning stroke density reconstruction (1836–2015)

description: <strong>The HistLight global lightning stroke density reconstruction (1836–2015)</strong> This repository contains a global estimate of past lightning stroke density based on the WGLC and the 20th Century Reanalysis. The reconstruction was made by regressing monthly mean observed lightning density from the WGLC against monthly mean Convective Available Potential Energy (CAPE) from the 20th Century Reanalysis during the six-year period of overlap (2010-2015). The linear regression was made on a log(WGLC) : log(CAPE) basis. In areas where the explanatory power of the regression model was not statistically significant (P&gt;0.05), no CAPE-based reconstruction was made, and the missing values were filled with the 2010-2015 climatological monthly mean lightning from the WGLC. Further details of the preparation of this dataset will be described in a forthcoming manuscript. <strong>Technical features</strong> The data are stored in a NetCDF (version 4) file and have the following attributes: Spatial extent: Entire Earth Spatial reference system (SRS): Unprojected (geographic, WGS84) Spatial resolution: half-degree Temporal extent: 1836-2015 (time coordinate refers to the first day of the month) Temporal resolution: monthly <strong>Variables included in this release</strong> Lightning density (lght) (strokes km<sup>-2</sup> day<sup>-1</sup>)
DOI: 10.5281/zenodo.6405395
title: The HistLight global lightning stroke density reconstruction (1836–2015)

description: <strong>The HistLight global lightning stroke density reconstruction (1836–2015)</strong> This repository contains a global estimate of past lightning stroke density based on the WGLC and the 20th Century Reanalysis. The reconstruction was made by regressing monthly mean observed lightning density from the WGLC against monthly mean Convective Available Potential Energy (CAPE) from the 20th Century Reanalysis during the six-year period of overlap (2010-2015). The linear regression was made on a log(WGLC) : log(CAPE) basis. In areas where the explanatory power of the regression model was not statistically significant (P&gt;0.05), no CAPE-based reconstruction was made, and the missing values were filled with the 2010-2015 climatological monthly mean lightning from the WGLC. Further details of the preparation of this dataset will be described in a forthcoming manuscript. <strong>Technical features</strong> The data are stored in a NetCDF (version 4) file and have the following attributes: Spatial extent: Entire Earth Spatial reference system (SRS): Unprojected (geographic, WGS84) Spatial resolution: half-degree Temporal extent: 1836-2015 (time coordinate refers to the first day of the month) Temporal resolution: monthly <strong>Variables included in this release</strong> Lightning density (lght) (strokes km<sup>-2</sup> day<sup>-1</sup>)
DOI: 10.34740/kaggle/dsv/3392014
title: Jewellery Dataset