cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.5861523.v1
title: Chagas disease and systemic autoimmune diseases among Bolivian patients in Switzerland

description: BACKGROUND Chronic cardiomyopathy occurs in 20-40% of the patients with Chagas disease. Autoimmune mechanisms may contribute to its pathogenesis. We diagnosed several cases of systemic autoimmune diseases among Bolivian migrants in Geneva with a high prevalence of Chagas disease. OBJECTIVES We tested the hypothesis of a clinical association between systemic autoimmune diseases and Chagas disease, particularly with the development of cardiomyopathy. METHODS We retrospectively searched the medical records of all Bolivian patients visiting Geneva University Hospitals between 2012 and 2015 for diagnosis of Chagas disease or systemic autoimmune diseases. FINDINGS Of the 2,189 eligible patients, 28 [1.3%; 95% confidence interval (CI) = 0.9-1.9%] presented with systemic autoimmune disease. The Chagas status was known in 903 (41.3%) patient, of whom 244 (27.0%; 95% CI = 24.2-30.0%) were positive. Eight (28.6%; 95% CI = 15.3-47.1%) of the 28 cases of systemic autoimmune disease had Chagas disease. We found no association between both entities (p = 1.000) or with Chagasic cardiomyopathy (p = 0.729). Moreover, there was no evidence of a temporal relationship between antiparasitic chemotherapy and the development of systemic autoimmune diseases. CONCLUSIONS Our results do not support a clinical association between chronic Chagas disease and systemic autoimmune diseases. However, prospective studies in areas endemic for Chagas disease should better assess the prevalence of systemic autoimmune diseases and thus a possible relationship with this infection.
DOI: 10.6084/m9.figshare.5861502
title: Quality peach produced in fertilizer doses of nitrogen and green pruning

description: ABSTRACT The increasing consumer demand for fruit quality justifies the development of researches that combine orchards management and consumers’ perception of the quality of the product. The aim of this study was to evaluate the effect of nitrogen fertilization combined with green pruning intensity on fruit quality of ‘Chimarrita’ from high density peach trees during three consecutive harvest seasons. For this purpose, urea composed of different nitrogen rates (0, 40, 80, 120, 160, 200 and 240 kg.ha-1.year-1) was applied, under two intensities of green pruning (annual – once per season; or continuous – four times per season) in a factorial scheme (7 × 2). Fruits have been subjected to physical, chemical and sensorial analysis, made by 60 non-trained evaluators in each of the harvest seasons. The results showed that the cumulative effect of applying N in the third harvest season improved SS attributes, SS/TA ratio and fruit skin color to the dose of N of 148 kg.ha-1 .year-1. There is no difference between green pruning intensity and peach fruit quality.
DOI: 10.6084/m9.figshare.5861502.v1
title: Quality peach produced in fertilizer doses of nitrogen and green pruning

description: ABSTRACT The increasing consumer demand for fruit quality justifies the development of researches that combine orchards management and consumers’ perception of the quality of the product. The aim of this study was to evaluate the effect of nitrogen fertilization combined with green pruning intensity on fruit quality of ‘Chimarrita’ from high density peach trees during three consecutive harvest seasons. For this purpose, urea composed of different nitrogen rates (0, 40, 80, 120, 160, 200 and 240 kg.ha-1.year-1) was applied, under two intensities of green pruning (annual – once per season; or continuous – four times per season) in a factorial scheme (7 × 2). Fruits have been subjected to physical, chemical and sensorial analysis, made by 60 non-trained evaluators in each of the harvest seasons. The results showed that the cumulative effect of applying N in the third harvest season improved SS attributes, SS/TA ratio and fruit skin color to the dose of N of 148 kg.ha-1 .year-1. There is no difference between green pruning intensity and peach fruit quality.
DOI: 10.6084/m9.figshare.5861484
title: Heterogeneous photo-Fenton and photocatalytic degradation studies of 2-chloro-4-nitrophenol (2Cl4NP) using foundry sand and TiO2 coated cement/clay beads

description: ABSTRACT Cement and clay beads coated with TiO2were used for the photo-degradation and mineralization of 2-chloro-4-nitrophenol (2Cl4NP) along with a heterogeneous solar photo-Fenton process using foundry sand (FS) as the iron source. The degradation process was optimized using slurry photocatalysis where 96% degradation of 2Cl4NP was achieved in 120 min at optimized conditions of C0=50 mgL-1, pH=4, 0.75 gL-1 TiO2 and H2O2= 0.1 mL/200 mL. Degradation of 2Cl4NP was analyzed through HPLC along with UV-Visible spectrophotometer at 266 nm. The degradation of 68% and 52% of 2Cl4NP was attained in fixed-bed photocatalysis using cement and clay beads, respectively. The durability studies of cement and clay beads were carried out in terms of number of recycles. 97.19% degradation was obtained in a solar photo-Fenton process after 105 min at pH=3. Complete mineralization of 2Cl4NP was confirmed through reduction in COD along with the disappearance of the parent compound peak in HPLC chromatograms.
DOI: 10.6084/m9.figshare.5861484.v1
title: Heterogeneous photo-Fenton and photocatalytic degradation studies of 2-chloro-4-nitrophenol (2Cl4NP) using foundry sand and TiO2 coated cement/clay beads

description: ABSTRACT Cement and clay beads coated with TiO2were used for the photo-degradation and mineralization of 2-chloro-4-nitrophenol (2Cl4NP) along with a heterogeneous solar photo-Fenton process using foundry sand (FS) as the iron source. The degradation process was optimized using slurry photocatalysis where 96% degradation of 2Cl4NP was achieved in 120 min at optimized conditions of C0=50 mgL-1, pH=4, 0.75 gL-1 TiO2 and H2O2= 0.1 mL/200 mL. Degradation of 2Cl4NP was analyzed through HPLC along with UV-Visible spectrophotometer at 266 nm. The degradation of 68% and 52% of 2Cl4NP was attained in fixed-bed photocatalysis using cement and clay beads, respectively. The durability studies of cement and clay beads were carried out in terms of number of recycles. 97.19% degradation was obtained in a solar photo-Fenton process after 105 min at pH=3. Complete mineralization of 2Cl4NP was confirmed through reduction in COD along with the disappearance of the parent compound peak in HPLC chromatograms.
DOI: 10.6084/m9.figshare.5861442
title: An imperial laboratory: the investigation and treatment of treponematoses in occupied Haiti, 1915-1934

description: This article examines anti-treponematoses work as part of US occupation public health policy in Haiti, a unique event in the history of international health. Yaws was highly prevalent in Haiti, but occupation doctors initially ignored it because of its close association with syphilis and stigmas attached to sexually transmitted disease. This changed when C.S. Butler asserted that yaws was “innocent” and that the two diseases should therefore be considered as one. Treatment increased as an anti-treponematoses campaign was now believed to hold great benefits for the occupation’s paternalist and strategic aims, even though it ultimately failed. This work reflected Haiti’s status as a public health “laboratory” which affected Haitian medicine for years to come and significantly influenced future campaigns aimed at disease eradication.
DOI: 10.6084/m9.figshare.5861442.v1
title: An imperial laboratory: the investigation and treatment of treponematoses in occupied Haiti, 1915-1934

description: This article examines anti-treponematoses work as part of US occupation public health policy in Haiti, a unique event in the history of international health. Yaws was highly prevalent in Haiti, but occupation doctors initially ignored it because of its close association with syphilis and stigmas attached to sexually transmitted disease. This changed when C.S. Butler asserted that yaws was “innocent” and that the two diseases should therefore be considered as one. Treatment increased as an anti-treponematoses campaign was now believed to hold great benefits for the occupation’s paternalist and strategic aims, even though it ultimately failed. This work reflected Haiti’s status as a public health “laboratory” which affected Haitian medicine for years to come and significantly influenced future campaigns aimed at disease eradication.
DOI: 10.6084/m9.figshare.5861436
title: Primary care assessment from a male population perspective

description: ABSTRACT Objective: to evaluate the quality of primary health care from the perspective of the male population. Method: a cross-sectional descriptive-evaluative study conducted at the family health units of Teresina, Piauí, Brazil, with the male population being interviewed through the Primary Care Assessment Tool (PCAT). Results: 301 participants with mean age of 51.34 years, married, incomplete elementary school and monthly income between one and two minimum wages. The evaluation was positive for the following care domains: utilization, information system and longitudinality. The features access, comprehensiveness of care, service available and service provided, family centeredness and community orientation obtained a negative evaluation. Conclusion: the features of primary care are unsatisfactory, indicating the need to expand access to services offered and to qualify care for male users.
DOI: 10.6084/m9.figshare.5861430
title: Effect of Erosion/Abrasion Challenge on the Dentin Tubule Occlusion Using Different Desensitizing Agents

description: The aim of the study was to evaluate dentinal tubule occlusion, measuring the dentin permeability (Lp) and using different desensitizing agents before and after abrasive/erosive challenge. Dentin discs from 42 healthy human third molars were obtained. Minimum Lp was measured after a smear layer simulation using #600 SiC paper and maximum Lp after an immersion in 0.5 M EDTA. The specimens were treated with different desensitizers: two varnishes (Clinpro XT Varnish-CV, Fluor Protector-FP), a paste (Desensibilize Nano P-NP) and a gel (Oxa Gel-OG). The Lp of each specimen was measured immediately after the desensitizers’ application. The discs were subjected to erosion/abrasion cycles for 7 days, with 0.5% citric acid solution (6x/day) and tooth brushing (3x/day). Lp was measured after the first, fourth and seventh day of the challenge. The data were analyzed by 3-way ANOVA with repeated measurements and by a Games-Howell test (α=5%). FP and CV did not show significant differences in Lp immediately after application until the 7th day (p&lt;0.05). OG showed a significant increase in Lp after the 4th and 7th days. NP resulted in a significantly higher permeability compared to the other materials immediately after the application and after the 1st day of challenge. All the desensitizers reduced the dentin permeability immediately after application. However, only the varnishes were able to maintain the occlusive effect after the erosion/abrasion challenge.
DOI: 10.6084/m9.figshare.5861436.v1
title: Primary care assessment from a male population perspective

description: ABSTRACT Objective: to evaluate the quality of primary health care from the perspective of the male population. Method: a cross-sectional descriptive-evaluative study conducted at the family health units of Teresina, Piauí, Brazil, with the male population being interviewed through the Primary Care Assessment Tool (PCAT). Results: 301 participants with mean age of 51.34 years, married, incomplete elementary school and monthly income between one and two minimum wages. The evaluation was positive for the following care domains: utilization, information system and longitudinality. The features access, comprehensiveness of care, service available and service provided, family centeredness and community orientation obtained a negative evaluation. Conclusion: the features of primary care are unsatisfactory, indicating the need to expand access to services offered and to qualify care for male users.
DOI: 10.6084/m9.figshare.5861430.v1
title: Effect of Erosion/Abrasion Challenge on the Dentin Tubule Occlusion Using Different Desensitizing Agents

description: The aim of the study was to evaluate dentinal tubule occlusion, measuring the dentin permeability (Lp) and using different desensitizing agents before and after abrasive/erosive challenge. Dentin discs from 42 healthy human third molars were obtained. Minimum Lp was measured after a smear layer simulation using #600 SiC paper and maximum Lp after an immersion in 0.5 M EDTA. The specimens were treated with different desensitizers: two varnishes (Clinpro XT Varnish-CV, Fluor Protector-FP), a paste (Desensibilize Nano P-NP) and a gel (Oxa Gel-OG). The Lp of each specimen was measured immediately after the desensitizers’ application. The discs were subjected to erosion/abrasion cycles for 7 days, with 0.5% citric acid solution (6x/day) and tooth brushing (3x/day). Lp was measured after the first, fourth and seventh day of the challenge. The data were analyzed by 3-way ANOVA with repeated measurements and by a Games-Howell test (α=5%). FP and CV did not show significant differences in Lp immediately after application until the 7th day (p&lt;0.05). OG showed a significant increase in Lp after the 4th and 7th days. NP resulted in a significantly higher permeability compared to the other materials immediately after the application and after the 1st day of challenge. All the desensitizers reduced the dentin permeability immediately after application. However, only the varnishes were able to maintain the occlusive effect after the erosion/abrasion challenge.
DOI: 10.6084/m9.figshare.5861427
title: Construction and validation of clinical contents for development of learning objects

description: ABSTRACT Objective: to describe the process of construction and validation of clinical contents for health learning objects, aimed at patients in the treatment of head and neck cancer. Method: descriptive, methodological study. The development of the script and the storyboard were based on scientific evidence and submitted to the appreciation of specialists for validation of content. The agreement index was checked quantitatively and the suggestions were qualitatively evaluated. Results: The items described in the roadmap were approved by 99% of expert experts. The suggestions for adjustments were inserted in their entirety in the final version. The free-marginal kappa statistical test, for multiple evaluators, presented value equal to 0.68%, granting a substantial agreement. Conclusion: The steps taken in the construction and validation of the content for the production of educational material for patients with head and neck cancer were adequate, relevant and suitable for use in other subjects.
DOI: 10.6084/m9.figshare.5861427.v1
title: Construction and validation of clinical contents for development of learning objects

description: ABSTRACT Objective: to describe the process of construction and validation of clinical contents for health learning objects, aimed at patients in the treatment of head and neck cancer. Method: descriptive, methodological study. The development of the script and the storyboard were based on scientific evidence and submitted to the appreciation of specialists for validation of content. The agreement index was checked quantitatively and the suggestions were qualitatively evaluated. Results: The items described in the roadmap were approved by 99% of expert experts. The suggestions for adjustments were inserted in their entirety in the final version. The free-marginal kappa statistical test, for multiple evaluators, presented value equal to 0.68%, granting a substantial agreement. Conclusion: The steps taken in the construction and validation of the content for the production of educational material for patients with head and neck cancer were adequate, relevant and suitable for use in other subjects.
DOI: 10.6084/m9.figshare.5861418
title: Journal Club: a group of research experience

description: ABSTRACT Introduction: the Journal Club (JC) is a teaching and learning strategy developed by individuals who meet to discuss scientific articles in periodicals. Objective: to describe the experience of the JC strategy at the Group for Studies and Research in Health Services Administration and Nursing Management (Gepag). Method: case studies or scientific research demonstration mode of practical experience for the understanding and justification of facts. Results: Gepag JC emerged in 2008 and, in 2014, was computerized with the Google Drive®, in order to increase its scope and optimize the Group›s meetings. From April to May 2014, the instrument was tested and adjusted, resulting in advancements. Final considerations: the advantages involved optimizing the time of meetings, facilitation of access to publications of interest to the Group and creating the database to support future research.
DOI: 10.6084/m9.figshare.5861418.v1
title: Journal Club: a group of research experience

description: ABSTRACT Introduction: the Journal Club (JC) is a teaching and learning strategy developed by individuals who meet to discuss scientific articles in periodicals. Objective: to describe the experience of the JC strategy at the Group for Studies and Research in Health Services Administration and Nursing Management (Gepag). Method: case studies or scientific research demonstration mode of practical experience for the understanding and justification of facts. Results: Gepag JC emerged in 2008 and, in 2014, was computerized with the Google Drive®, in order to increase its scope and optimize the Group›s meetings. From April to May 2014, the instrument was tested and adjusted, resulting in advancements. Final considerations: the advantages involved optimizing the time of meetings, facilitation of access to publications of interest to the Group and creating the database to support future research.
DOI: 10.6084/m9.figshare.5861406
title: The development and validation of an ergonomics index for assessing tractor operator work place

description: ABSTRACT: This study aimed to develop and validate an ergonomics index for the operator workplace assessment of agricultural tractors sold in the Brazilian market. To develop the ergonomics index, the operator work places were assessed for compliance with current, national and international, safety and ergonomics standards. The following standards were analyzed to develop ergonomics index: ISO 15077 (1996), which regulates the position of operator controls; ABNT NBR ISO 4254-1(2015) and ABNT NBR ISO 4252 (2011), which regulate the access to operator workplaces; and NR 12 (2010), which determines the mandatory items of operator workplaces.Thirty-four operator work places of 152 models of new agricultural tractors sold in the Brazilian market were analyzed in this study. Ergonomics index was developed and validated using these standards, and the findings enabled the ranking of agricultural tractors. Therefore, the proposed ergonomics index proved feasible and may be applied to other agricultural machines.
DOI: 10.6084/m9.figshare.5861406.v1
title: The development and validation of an ergonomics index for assessing tractor operator work place

description: ABSTRACT: This study aimed to develop and validate an ergonomics index for the operator workplace assessment of agricultural tractors sold in the Brazilian market. To develop the ergonomics index, the operator work places were assessed for compliance with current, national and international, safety and ergonomics standards. The following standards were analyzed to develop ergonomics index: ISO 15077 (1996), which regulates the position of operator controls; ABNT NBR ISO 4254-1(2015) and ABNT NBR ISO 4252 (2011), which regulate the access to operator workplaces; and NR 12 (2010), which determines the mandatory items of operator workplaces.Thirty-four operator work places of 152 models of new agricultural tractors sold in the Brazilian market were analyzed in this study. Ergonomics index was developed and validated using these standards, and the findings enabled the ranking of agricultural tractors. Therefore, the proposed ergonomics index proved feasible and may be applied to other agricultural machines.
DOI: 10.6084/m9.figshare.5861403
title: Use of unlicensed and off-label drugs in neonates in a Brazilian university hospital

description: ABSTRACT This study was designed to investigate the use of off-label and unlicensed drugs in a Neonatal Care Unit (NCU) and to compare the frequency of use of off-label drugs according to the drug regulatory agencies in Brazil (Agência Nacional de Vigilância Sanitária-ANVISA) and the United States Food and Drug Administration (FDA). A prospective observational study was carried out in the NCU. Prescriptions were classified as off-label and unlicensed using both ANVISA and FDA criteria. A total of 157 newborns and 1187 prescriptions were analyzed. The most prescribed drug was fentanyl (9.3%), followed by multivitamin (8.4%) and gentamicin (7.9%). According to ANVISA criteria, there were 665 (56.0%) off-label prescriptions and 86 (7.2%) unlicensed prescriptions and 95.5% of newborns received at least one drug off-label. By contrast, according to FDA criteria, there were 592 (49.9%) off-label prescriptions and 84 (7.1%) unlicensed prescriptions, and 72.0% of newborns received at least one drug off-label. The off-label use of drugs registered by ANVISA differed significantly from that of drugs registered by the FDA. There was a high frequency of off-label and unlicensed drug use in the investigated NCU, and there was an inverse relationship between off-label and unlicensed usage and the gestational age of the newborns.
DOI: 10.6084/m9.figshare.5861403.v1
title: Use of unlicensed and off-label drugs in neonates in a Brazilian university hospital

description: ABSTRACT This study was designed to investigate the use of off-label and unlicensed drugs in a Neonatal Care Unit (NCU) and to compare the frequency of use of off-label drugs according to the drug regulatory agencies in Brazil (Agência Nacional de Vigilância Sanitária-ANVISA) and the United States Food and Drug Administration (FDA). A prospective observational study was carried out in the NCU. Prescriptions were classified as off-label and unlicensed using both ANVISA and FDA criteria. A total of 157 newborns and 1187 prescriptions were analyzed. The most prescribed drug was fentanyl (9.3%), followed by multivitamin (8.4%) and gentamicin (7.9%). According to ANVISA criteria, there were 665 (56.0%) off-label prescriptions and 86 (7.2%) unlicensed prescriptions and 95.5% of newborns received at least one drug off-label. By contrast, according to FDA criteria, there were 592 (49.9%) off-label prescriptions and 84 (7.1%) unlicensed prescriptions, and 72.0% of newborns received at least one drug off-label. The off-label use of drugs registered by ANVISA differed significantly from that of drugs registered by the FDA. There was a high frequency of off-label and unlicensed drug use in the investigated NCU, and there was an inverse relationship between off-label and unlicensed usage and the gestational age of the newborns.