cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.17639/nott.7298
title: Dataset for Designing and simulating realistic spatial frequency domain imaging systems using open-source 3D rendering software

description: Dataset and code for simulations and analysis presented in paper "Designing and simulating realistic spatial frequency domain imaging systems using open-source 3D rendering software"
DOI: 10.17639/nott.7185
title: A verbatim film-research collaboration seeking to raise awareness of prison suicide
title: Overall Project Title – Prison Regulation, for Safer Societies: Participatory, Effective, Efficient?

description: This short (15m) film produced by Lung features a mother whose son ended his own life in prison in 2013, it explores bereavement by prison suicide and the formal investigations that follow. It was produced to help disseminate findings from a broader study of prison regulation (2020-2024). Traditional academic research presentations can reduce the people at their centre to data and statistics. Film provided a means of meaningfully including lived experiences in our dissemination strategy and emotionally engaging attendees. Whilst this one mother’s experiences do not represent the diverse needs of those who have lost loved ones in prison, hers is not an isolated case. In a three-year period, between May 2013 – December 2016, 18 prisoners took their own lives at the prison which the film features (Tomczak, 2018). During this period, the prison combined multiple complex functions and serious staff cuts and shortages had led to boredom and isolation amongst prisoners, which are major contributing factors for self-harm. Furthermore, suicide prevention policies were designed when there were significantly more prison staff and significantly fewer prisoners (Tomczak, 2022). The film itself is a co-created ‘verbatim’ account of a mother’s experience. Professional choreographers and musicians added dramatic interpretations. Tomczak’s research team funded the film and wraparound therapeutic support, and shared research findings and ethics resources. The mother who features in the film made the informed choice to appear in the film herself. As this means the film is deeply personal and identifies people involved, it is screened only in organised research and training events, which the co-creators are always given the opportunity to collaborate on. It has not been made publicly available to mitigate prejudice, misuse and abuse. Please see attached Word document for a request form for a private short-term access link for an agreed purpose and audience. As this film features suicide, we recommend that screeners signpost audiences to supports. E.g., Samaritans offer a free 24/7 confidential listener line 116 123. This and other signposts are included in the film’s postscript. A Q&A with filmmakers can be arranged to accompany the film, contact Matt Woodhead for details info@lungtheatre.co.uk Rights owners (and main point of contact for enquiries about the film) Matt Woodhead, LUNG. info@lungtheatre.co.uk
DOI: 10.17639/nott.7391
title: United Kingdom QR value per 4* output or impact case study returned to REF in the 2023-2024 financial year

description: Data is a collation of Quality-Related (QR) funding allocations to UK institutions as published by UKRI. Additional information is included, such as number of outputs and impact case studies expected from a submission with the respective number of FTE; and calculation for QR value of a 4* output and a 4* impact case study. Original data acquired from: https://www.ukri.org/publications/higher-education-provider-grant-data-tables-2023-to-2024/
DOI: 10.17639/nott.7080
title: Data for Discovery of synergistic material-topography combinations to achieve immunomodulatory osteoinductive biomaterials using a novel in vitro screening method: The ChemoTopoChip

description: Human mesenchymal stem cells (hMSCs) are widely represented in regenerative medicine clinical strategies due to their compatibility with autologous implantation. Effective bone regeneration involves crosstalk between macrophages and hMSCs, with macrophages playing a key role in the recruitment and differentiation of hMSCs. However, engineered biomaterials able to simultaneously direct hMSC fate and modulate macrophage phenotype have not yet been identified. A novel combinatorial chemistry-topography screening platform, the ChemoTopoChip, is used here to identify materials suitable for bone regeneration by screening 1008 combinations in each experiment for human immortalized mesenchymal stem cell (hiMSCs) and human macrophage response. The osteoinduction achieved in hiMSCs cultured on the “hit” materials in basal media is comparable to that seen when cells are cultured in osteogenic media, illustrating that these materials offer a materials-induced alternative to osteo-inductive supplements in bone-regeneration. Some of these same chemistry-microtopography combinations also exhibit immunomodulatory stimuli, polarizing macrophages towards a pro-healing phenotype. Maximum control of cell response is achieved when both chemistry and topography are recruited to instruct the required cell phenotype, combining synergistically. The large combinatorial library allows us for the first time to probe the relative cell-instructive roles of microtopography and material chemistry which we find to provide similar ranges of cell modulation for both cues. Machine learning is used to generate structure-activity relationships that identify key chemical and topographical features enhancing the response of both cell types, providing a basis for a better understanding of cell response to micro topographically patterned polymers.
DOI: 10.17639/nott.6508
title: An in vivo systematic genetic analysis of tumour progression in Drosophila - RNAi line: 29024

description: This data set forms part of the larger 'Fly Cancer Screen' data set, which consists of over 700 image sets
description: Metastasis is the leading cause of death for cancer patients. Consequently it is imperative that we improve our understanding of the molecular mechanisms that underlie progression of tumour growth towards malignancy. Advances in genome characterisation technologies have been very successful in identifying commonly mutated or misregulated genes in a variety of human cancers. A major challenge however is the translation of these findings to new biological insight due to the difficulty in evaluating whether these candidate genes drive tumour progression. Using the genetic amenability of Drosophila melanogaster we generated tumours with specific genotypes in the living animal and carried out a detailed systematic loss-of-function analysis to identify numerous conserved genes that enhance or suppress epithelial tumour progression. This enabled the discovery of functional cooperative regulators of invasion and the establishment of a network of conserved ‘invasion suppressors’. RNAi line: 29024 (III) Source: VDRC Name: CycD Full name: Cyclin D Also known as: cyclinD, dCycD, Cdi3 Annotation symbol: CG9096 FlyBase ID: FBgn0010315 File naming convention: File names typically contain representations of date (DDMMYY), RNAi Line, Animal Number and, in some cases, window (to accommodate larger samples that require multiple image stacks)
DOI: 10.17639/nott.7234
title: The Lived Experience of Trainees and Supervisors regarding Mentoring in UK Postgraduate Medical Training: A descriptive phenomenological approach

description: The aim of this study is to better understand the phenomenon of mentoring that occurs in UK postgraduate medical training programs by describing it from the lived experiences of trainees and supervisors. The process will include interviewing trainees and supervisors from various programs in the UK, asking them to describe their lived experiences regarding the concept of mentoring as part of the trainee-supervisor relationship, as well throughout their career in general. Depending on what they say, themes will be deduced to summarize their descriptions of mentoring within their supervision (using the Colaizzi method of Data Analysis).
DOI: 10.17639/nott.7224
title: Raw Data for Magnetic order in a metal thiocyanate perovskite-analogue
title: Raw Data for Magnetic order in a metal thiocyanate perovskite analogue

description: Data include: - neutron diffraction data - neutron diffraction refinement - infrared spectrum - bulk magnetic measurements
DOI: 10.17639/nott.7226
title: Effect of popping water content and amylose/amylopectin ratio on the physical properties of expanded starch products with different shear histories - data

description: Data collected for and presented in the research paper titled "Effect of popping water content and amylose/amylopectin ratio on the physical properties of expanded starch products with different shear histories".
DOI: 10.17639/nott.7235
title: A linear, binary classifier to predict bacterial biofilm formation on polyacrylates

description: Datafiles, in Microsoft Excel format, associated with the manuscript "A linear, binary classifier to predict bacterial biofilm formation on polyacrylates" These files contain ToF-SIMS ion peaks and the bacterial attachment data.
DOI: 10.17639/nott.7229
title: The effect of popping, a sustainable form of processing, on antinutritional factors in pulses - Data

description: Raw data associated with the research paper titled "The effect of popping, a sustainable form of processing, on antinutritional factors in pulses".
DOI: 10.17639/nott.7233
title: Spectroscopic data from "Photochemical approaches to azetidines"

description: Raw data from the thesis entitled "Photochemical Approaches to Azetidines" Physical sciences::Chemistry::Organic chemistry Q Science::QD Chemistry::QD241 Organic chemistry
DOI: 10.17639/nott.6499
title: An in vivo systematic genetic analysis of tumour progression in Drosophila - RNAi line: 21757

description: This data set forms part of the larger 'Fly Cancer Screen' data set, which consists of over 700 image sets
description: Metastasis is the leading cause of death for cancer patients. Consequently it is imperative that we improve our understanding of the molecular mechanisms that underlie progression of tumour growth towards malignancy. Advances in genome characterisation technologies have been very successful in identifying commonly mutated or misregulated genes in a variety of human cancers. A major challenge however is the translation of these findings to new biological insight due to the difficulty in evaluating whether these candidate genes drive tumour progression. Using the genetic amenability of Drosophila melanogaster we generated tumours with specific genotypes in the living animal and carried out a detailed systematic loss-of-function analysis to identify numerous conserved genes that enhance or suppress epithelial tumour progression. This enabled the discovery of functional cooperative regulators of invasion and the establishment of a network of conserved ‘invasion suppressors’. RNAi line: 21757 (III) Source: VDRC Name: csw Full name: corkscrew Also known as: E(sev)1A, EG:BACN25G24 .2, l(1)csw, l(1)2Db, l(1)G0170 Annotation symbol: CG3954 FlyBase ID: FBgn0000382 File naming convention: File names typically contain representations of date (DDMMYY), RNAi Line, Animal Number and, in some cases, window (to accommodate larger samples that require multiple image stacks)
DOI: 10.17639/nott.6495
title: An in vivo systematic genetic analysis of tumour progression in Drosophila - RNAi line: 6383R2

description: This data set forms part of the larger 'Fly Cancer Screen' data set, which consists of over 700 image sets
description: Metastasis is the leading cause of death for cancer patients. Consequently it is imperative that we improve our understanding of the molecular mechanisms that underlie progression of tumour growth towards malignancy. Advances in genome characterisation technologies have been very successful in identifying commonly mutated or misregulated genes in a variety of human cancers. A major challenge however is the translation of these findings to new biological insight due to the difficulty in evaluating whether these candidate genes drive tumour progression. Using the genetic amenability of Drosophila melanogaster we generated tumours with specific genotypes in the living animal and carried out a detailed systematic loss-of-function analysis to identify numerous conserved genes that enhance or suppress epithelial tumour progression. This enabled the discovery of functional cooperative regulators of invasion and the establishment of a network of conserved ‘invasion suppressors’. RNAi line: 6383R2 (III) Source: NIG Name: crb (1) Full name: crumbs Also known as: Crumbs, l(3)07207, Crbs, far, l(3)j1B5 Annotation symbol: CG6383 FlyBase ID: FBgn0259685 File naming convention: File names typically contain representations of date (DDMMYY), RNAi Line, Animal Number and, in some cases, window (to accommodate larger samples that require multiple image stacks)
DOI: 10.17639/nott.6497
title: An in vivo systematic genetic analysis of tumour progression in Drosophila - RNAi line: 13383R-3

description: This data set forms part of the larger 'Fly Cancer Screen' data set, which consists of over 700 image sets
description: Metastasis is the leading cause of death for cancer patients. Consequently it is imperative that we improve our understanding of the molecular mechanisms that underlie progression of tumour growth towards malignancy. Advances in genome characterisation technologies have been very successful in identifying commonly mutated or misregulated genes in a variety of human cancers. A major challenge however is the translation of these findings to new biological insight due to the difficulty in evaluating whether these candidate genes drive tumour progression. Using the genetic amenability of Drosophila melanogaster we generated tumours with specific genotypes in the living animal and carried out a detailed systematic loss-of-function analysis to identify numerous conserved genes that enhance or suppress epithelial tumour progression. This enabled the discovery of functional cooperative regulators of invasion and the establishment of a network of conserved ‘invasion suppressors’. RNAi line: 13383R-3 (III) Source: NIG Name: CSN8 (1) Full name: COP9 signalosome subunit 8 Also known as: Annotation symbol: CG42522 FlyBase ID: FBgn0261437 File naming convention: File names typically contain representations of date (DDMMYY), RNAi Line, Animal Number and, in some cases, window (to accommodate larger samples that require multiple image stacks)
DOI: 10.17639/nott.6437
title: An in vivo systematic genetic analysis of tumour progression in Drosophila - RNAi line: 3839

description: This data set forms part of the larger 'Fly Cancer Screen' data set, which consists of over 700 image sets
description: Metastasis is the leading cause of death for cancer patients. Consequently it is imperative that we improve our understanding of the molecular mechanisms that underlie progression of tumour growth towards malignancy. Advances in genome characterisation technologies have been very successful in identifying commonly mutated or misregulated genes in a variety of human cancers. A major challenge however is the translation of these findings to new biological insight due to the difficulty in evaluating whether these candidate genes drive tumour progression. Using the genetic amenability of Drosophila melanogaster we generated tumours with specific genotypes in the living animal and carried out a detailed systematic loss-of-function analysis to identify numerous conserved genes that enhance or suppress epithelial tumour progression. This enabled the discovery of functional cooperative regulators of invasion and the establishment of a network of conserved ‘invasion suppressors’. RNAi line: 3839 (III) Source: VDRC Name: CG4587 (2) Full name: Also known as: BG:DS07108 .2 Annotation symbol: CG4587 FlyBase ID: FBgn0028863 File naming convention: File names typically contain representations of date (DDMMYY), RNAi Line, Animal Number and, in some cases, window (to accommodate larger samples that require multiple image stacks)
DOI: 10.17639/nott.6468
title: An in vivo systematic genetic analysis of tumour progression in Drosophila - RNAi line: 23075

description: This data set forms part of the larger 'Fly Cancer Screen' data set, which consists of over 700 image sets
description: Metastasis is the leading cause of death for cancer patients. Consequently it is imperative that we improve our understanding of the molecular mechanisms that underlie progression of tumour growth towards malignancy. Advances in genome characterisation technologies have been very successful in identifying commonly mutated or misregulated genes in a variety of human cancers. A major challenge however is the translation of these findings to new biological insight due to the difficulty in evaluating whether these candidate genes drive tumour progression. Using the genetic amenability of Drosophila melanogaster we generated tumours with specific genotypes in the living animal and carried out a detailed systematic loss-of-function analysis to identify numerous conserved genes that enhance or suppress epithelial tumour progression. This enabled the discovery of functional cooperative regulators of invasion and the establishment of a network of conserved ‘invasion suppressors’. RNAi line: 23075 (III) Source: VDRC Name: CG7911 Full name: Nucleophosmin Also known as: Nph Annotation symbol: CG7911 FlyBase ID: FBgn0039735 File naming convention: File names typically contain representations of date (DDMMYY), RNAi Line, Animal Number and, in some cases, window (to accommodate larger samples that require multiple image stacks)
DOI: 10.17639/nott.7093
title: Discovery of a novel polymer for xeno-free, long-term culture of human pluripotent stem cell expansion

description: Discovery of poly(TCDMDA-blend-BA) polymer substrate offers a cost-effective and xeno-free adherent culture system for human pluripotent stem cells (hPSCs) in E8 medium. This is a scalable substrate which can be readily applied to common tissue culture plasticware (TCP), whilst retaining stem cell integrity after long-term serial passage. Fulfillment of all regulatory cell culture requirements makes this a desirable expansion platform for clinical-scale, therapeutic and biomedical applications. Data presented herein includes fluorescence microscopy of high-throughput attachment screening studies.
DOI: 10.17639/nott.7090
title: A protocol for modelling chronic pain using the UK Biobank Brain Imaging Data

description: Protocol for work on modelling chronic pain using the UK Biobank Brain Imaging Data
DOI: 10.17639/nott.7242
title: On-surface polymerisation and self-assembly of DPP-based molecular wires

description: The incorporation of organic semiconducting materials within solid-state electronic devices provides a potential route to highly efficient photovoltaics, transistors, and light emitting diodes. Key to the realisation of such devices is efficient intramolecular charge transport within molecular species, as well as intermolecular/interdomain transport, which necessitates highly ordered supramolecular domains. The on-surface synthesis of polymeric organic materials (incorporating donor and/or acceptor moieties) is one pathway towards the production of highly ordered molecular domains. Here we study the formation of a polymer based upon a diketopyrrolopyrrole (DPP) monomer unit, possessing aryl-halide groups to facilitate on-surface covalent coupling and functionalised with alkyl chains which drive the self-assembly of both the monomer material prior to reaction and the domains of polymeric material following on-surface synthesis. The self-assembled structure of close-packed domains of the monomer units, and the ordered polymers, are investigated and characterised using scanning tunnelling microscopy and X-ray photoelectron spectroscopy.
DOI: 10.17639/nott.7267
title: The effects of goal–landmark distance on overshadowing: a replication in humans (Homo sapiens) of Goodyear and Kamil (2004)

description: Goodyear & Kamil (2004) assessed the ability of Clark’s nutcrackers to find buried food based on a cross-shaped array of landmarks at different distances from the goal. Their findings suggested that close landmarks overshadowed learning about distal landmarks, and this was attenuated when assessing the effect of distal landmarks on learning about close landmarks. In other words, the extent of overshadowing was moderated by landmark distance. In this study, we aimed to replicate their findings in human spatial navigation by using a virtual environment. Three groups of participants were trained in an open environment featuring orientation cues and they had to find a hidden goal with reference to 4 landmarks that were arranged in the shape of a cross and placed at different distances from the goal. Two of the four landmark distances were common across all three groups to allow a comparison of the extent of overshadowing under comparable conditions. Following training, all participants were tested with each of the 4 landmarks individually. Of particular interest was how well participants performed when tested with the common landmarks. Consistent with the results in birds, we observed better performance in the groups with more distal landmarks, suggesting that overshadowing was greater in the groups with closer landmarks and thus dependent on the spatial contiguity between the landmarks and the goal. Landmarks near the goal overshadowed landmarks far from the goal, but the opposite was not true. A second experiment, in which landmarks and orientation cues were misaligned in order to prevent the use of a straightforward solution to the task, replicated the results. The results are discussed in terms of a modification of Pearce’s configural model.
DOI: 10.17639/nott.7309
title: Embodied musicking dataset (clean & complete)

description: Complete and clean dataset from Embodied Musicking project. The original files and project are found at https://github.com/Creative-AI-Research-Group/embodiedMusickingDataset This project aimed to design, develop and demonstrate a unique dataset capturing human creativity from inside the embodied relationships of music performance. The understanding of such a critical and fruitful mesh of environment, embodiment, new goal creation, and human-machine cooperation, will allow this project to cast a new light on the role of embodiment in HDI in music. It gathered physiological and psychological data about the way in which human beings can create and enjoy music performance through their data streams. This dataset aimed to be be the first of its kind to deal with embodied creativity, and will have potential impact upon the fields of realtime performance, game engine integration, companion-bots, healthcare interventions through art, and other interpersonal interaction between people, their data and their machines. Our novel approach of forefronting musicking (over the score) in the process of musical creation will offer new pathways of exploration for those already examining computer models of musical creativity.
DOI: 10.17639/nott.7313
title: TrustScapes worksheets: a visualisation tool to capture stakeholders' concerns and recommendations about data protection, algorithmic bias, and online safety

description: The TrustScapes focus groups were held to explore stakeholders’ concerns and recommendations about AI chatbots in mental health care in the United Kingdom. For the TrustScapes methodological paper, the TrustScape worksheets created during the focus groups were provided to illustrate how the worksheets can be used.
DOI: 10.17639/nott.7265
title: Organoruthenium complexes containing phosphinodicarboxamide ligands

description: Spectroscopic and crystallographic data