cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.5281/zenodo.10171688
title: Dataset of paper "Wavelength synergistic effects in continuous flow-through water disinfection systems"

description: Dataset of paper "Wavelength synergistic effects in continuous flow-through water disinfection systems"
DOI: 10.4121/39356576-6144-465a-869c-e3e9c35e2dc6
title: Data underlying the publication "Heralded initialization of charge state and optical transition frequency of diamond tin-vacancy centers"

description: Data underlying the research article "Heralded initialization of charge state and optical transition frequency of diamond tin-vacancy centers". In this physics experiment, we demonstrate the heralded initialization of the charge state and optical frequency transition of tin-vacancy centers in diamond using (off-)resonant lasers, photon detection and real-time logic . The measurements are performed in a quantum optics setup.The dataset contains the measured data and the python code to analyse and reproduce the figures shown in the main text and appendix. The measurements are conducted with the Python 3 framework Quantum Measurement Interface (QMI) and data is collected with Python-based data acquisition framework Quantify. The measured and simulated data is stored in individual hdf5 files. Analysed data is stored in hdf5 files named processed dataset.<br>Read the README.txt<br>.ipynb: These are the notebooks that generates the main figures from the paper. It defines functions that are used for the analysis, loads the data, processes and visualizes it.<br>the *.npy files are the raw data files.<br>Further information on the acquisition and the processing of the data can be found in the supplementary of the paper.<br>
DOI: 10.4121/39356576-6144-465a-869c-e3e9c35e2dc6.v1
title: Data underlying the publication "Heralded initialization of charge state and optical transition frequency of diamond tin-vacancy centers"

description: Data underlying the research article "Heralded initialization of charge state and optical transition frequency of diamond tin-vacancy centers". In this physics experiment, we demonstrate the heralded initialization of the charge state and optical frequency transition of tin-vacancy centers in diamond using (off-)resonant lasers, photon detection and real-time logic . The measurements are performed in a quantum optics setup.The dataset contains the measured data and the python code to analyse and reproduce the figures shown in the main text and appendix. The measurements are conducted with the Python 3 framework Quantum Measurement Interface (QMI) and data is collected with Python-based data acquisition framework Quantify. The measured and simulated data is stored in individual hdf5 files. Analysed data is stored in hdf5 files named processed dataset.<br>Read the README.txt<br>.ipynb: These are the notebooks that generates the main figures from the paper. It defines functions that are used for the analysis, loads the data, processes and visualizes it.<br>the *.npy files are the raw data files.<br>Further information on the acquisition and the processing of the data can be found in the supplementary of the paper.<br>
DOI: 10.5281/zenodo.10171718
title: Spatial Informatics Group (SIG)_asdf

description: asdf
DOI: 10.5281/zenodo.10171717
title: Spatial Informatics Group (SIG)_asdf

description: asdf
DOI: 10.21338/ess7e02_3
title: ESS7 - integrated file, edition 2.3
DOI: 10.6073/pasta/f1b334187d0e377f42ccf647523dddcc
title: Hubbard Brook Experimental Forest: Mirror Lake Ice Cover 1968 - present

description: Mirror Lake is located within the Hubbard Brook Valley, NH and has been the subject of numerous continuous limnological investigations since the early 1960s. The long-term Mirror Lake record is part of the Hubbard Brook Watershed Ecosystem Record (HBWatER), which is a long-term record of weekly sampling of nine-gaged watersheds at HB and includes the stream draining Mirror Lake. This data set reports ice cover, ice in and ice out data beginning in 1968 and continuing through the present. The collection and management of the long-term record was initiated in 1963 by Gene E. Likens, F. Herbert Bormann, Robert S. Pierce, and Noye M. Johnson. HBWatER is currently sustained by Tammy Wooster (Cary IES) and Jeff Merriam (USFS) and the dataset is curated and maintained by a team of researchers: Emma Rosi (Cary IES), Emily Bernhardt (Duke), Lindsey Rustad (USFS), John Campbell (USFS), Bill McDowell (UNH), Charley Driscoll (Syracuse U.), Mark Green (Case Western), and Scott Bailey (USFS). Current Financial Support for HBWatER is provided by NSF LTREB # 1907683 and the USDA Forest Service Northern Research Station. These data were gathered as part of the Hubbard Brook Ecosystem Study (HBES). The HBES is a collaborative effort at the Hubbard Brook Experimental Forest, which is operated and maintained by the USDA Forest Service, Northern Research Station.
DOI: 10.6084/m9.figshare.24298222
title: Supplementary Material for: Identifying genetic factors of polycystic ovary syndrome in women with epilepsy: a whole-genome sequencing study

description: Introduction: Women with epilepsy (WWE) are more likely to develop reproductive endocrine disorders, especially polycystic ovary syndrome (PCOS). This study aimed to explore the genetic factors of PCOS in WWE in hope of improving individual precision diagnosis and treatment. Methods: WWE registered at West China Hospital between January 2021 and October 2021 were enrolled in this study. Demographic and epilepsy-related characteristics were recorded and blood samples were collected for hormones, glucose metabolism testing and whole-genome sequencing. Results: After sample sequencing, quality control and variants selection, association analyses were performed. Pathway analysis was performed to identify involved biological pathways. The overall and PCOS ‘burden score’ of each individual were calculated to count the deleterious variants. A total of 95 WWE was included in this study and 19 patients were diagnosed with PCOS. WWE with PCOS showed a significantly different hormone profiles and a tendency of impaired glucose metabolism. The mostly associated genes were ZFYVE28, COL19A1, SIK3, ANKK1, PPIG, and REPIN1. The top 3 canonical pathways are adipogenesis pathway, Epoxysqualene Biosynthesis Signaling, and Glutamate Degradation Signaling. The most significant common variant was rs11914038 located in gene CELSR1 and rs651748 located in gene ZBTB16. In HGC prioritizations, ITGA9, PNPLA2, and DAB2 are the top 3 genes having the shortest distance to known PCOS genes. Conclusion: Genetic factors involved in the abnormal regulation of glucose and insulin metabolism are likely to be associated with the comorbidity of PCOS in WWE. Interventions targeting these processes should be given more priority in clinical practice.
DOI: 10.6084/m9.figshare.24298222.v1
title: Supplementary Material for: Identifying genetic factors of polycystic ovary syndrome in women with epilepsy: a whole-genome sequencing study

description: Introduction: Women with epilepsy (WWE) are more likely to develop reproductive endocrine disorders, especially polycystic ovary syndrome (PCOS). This study aimed to explore the genetic factors of PCOS in WWE in hope of improving individual precision diagnosis and treatment. Methods: WWE registered at West China Hospital between January 2021 and October 2021 were enrolled in this study. Demographic and epilepsy-related characteristics were recorded and blood samples were collected for hormones, glucose metabolism testing and whole-genome sequencing. Results: After sample sequencing, quality control and variants selection, association analyses were performed. Pathway analysis was performed to identify involved biological pathways. The overall and PCOS ‘burden score’ of each individual were calculated to count the deleterious variants. A total of 95 WWE was included in this study and 19 patients were diagnosed with PCOS. WWE with PCOS showed a significantly different hormone profiles and a tendency of impaired glucose metabolism. The mostly associated genes were ZFYVE28, COL19A1, SIK3, ANKK1, PPIG, and REPIN1. The top 3 canonical pathways are adipogenesis pathway, Epoxysqualene Biosynthesis Signaling, and Glutamate Degradation Signaling. The most significant common variant was rs11914038 located in gene CELSR1 and rs651748 located in gene ZBTB16. In HGC prioritizations, ITGA9, PNPLA2, and DAB2 are the top 3 genes having the shortest distance to known PCOS genes. Conclusion: Genetic factors involved in the abnormal regulation of glucose and insulin metabolism are likely to be associated with the comorbidity of PCOS in WWE. Interventions targeting these processes should be given more priority in clinical practice.
DOI: 10.6084/m9.figshare.24572908
title: Supplementary Material for: Applying Artificial Intelligence to Identify Common Targets for Treatment of Asthma, Eczema, and Food Allergy

description: Allergic disorders are common diseases marked by the abnormal immune response towards foreign antigens that are not pathogens. Often patients with food allergy also suffer from asthma and eczema. Given the similarities of these diseases and a shortage of effective treatments, developing novel therapeutics against common targets of multiple allergies would offer an efficient and cost-effective treatment for patients. Herein, we employed the artificial intelligence-driven target discovery platform, PandaOmics, to identify common targets for treating asthma, eczema, and food allergy. Thirty-two case-control comparisons were generated from 15, 11, and 6 transcriptomics datasets related to asthma (558 cases, 315 controls), eczema (441 cases, 371 controls), and food allergy (208 cases, 106 controls) respectively, and allocated into three meta-analyses for target identification. Top-100 high-confidence targets and Top-100 novel targets were prioritized by PandaOmics for each allergic disease. Six common high-confidence targets (i.e., IL4R, IL5, JAK1, JAK2, JAK3, and NR3C1) across all three allergic diseases have approved drugs for treating asthma and eczema. Based on the targets’ dysregulated expression profiles and their mechanism of action in allergic diseases, three potential therapeutic targets were proposed. IL5 was selected as a high-confidence target due to its strong involvement in allergies. PTAFR was identified for drug repurposing, while RNF19B was selected as a novel target for therapeutic innovation. Analysis of the dysregulated pathways commonly identified across asthma, eczema, and food allergy revealed the well-characterized disease signature and novel biological processes that may underlie the pathophysiology of allergies. Altogether, our study dissects the shared pathophysiology of allergic disorders and reveals the power of artificial intelligence in the exploration of novel therapeutic targets.
DOI: 10.6084/m9.figshare.24572908.v1
title: Supplementary Material for: Applying Artificial Intelligence to Identify Common Targets for Treatment of Asthma, Eczema, and Food Allergy

description: Allergic disorders are common diseases marked by the abnormal immune response towards foreign antigens that are not pathogens. Often patients with food allergy also suffer from asthma and eczema. Given the similarities of these diseases and a shortage of effective treatments, developing novel therapeutics against common targets of multiple allergies would offer an efficient and cost-effective treatment for patients. Herein, we employed the artificial intelligence-driven target discovery platform, PandaOmics, to identify common targets for treating asthma, eczema, and food allergy. Thirty-two case-control comparisons were generated from 15, 11, and 6 transcriptomics datasets related to asthma (558 cases, 315 controls), eczema (441 cases, 371 controls), and food allergy (208 cases, 106 controls) respectively, and allocated into three meta-analyses for target identification. Top-100 high-confidence targets and Top-100 novel targets were prioritized by PandaOmics for each allergic disease. Six common high-confidence targets (i.e., IL4R, IL5, JAK1, JAK2, JAK3, and NR3C1) across all three allergic diseases have approved drugs for treating asthma and eczema. Based on the targets’ dysregulated expression profiles and their mechanism of action in allergic diseases, three potential therapeutic targets were proposed. IL5 was selected as a high-confidence target due to its strong involvement in allergies. PTAFR was identified for drug repurposing, while RNF19B was selected as a novel target for therapeutic innovation. Analysis of the dysregulated pathways commonly identified across asthma, eczema, and food allergy revealed the well-characterized disease signature and novel biological processes that may underlie the pathophysiology of allergies. Altogether, our study dissects the shared pathophysiology of allergic disorders and reveals the power of artificial intelligence in the exploration of novel therapeutic targets.
DOI: 10.6084/m9.figshare.24599001
title: 集成算法在蒸散发估算中的性能及其机制

description: 数据处理、集成算法和贝叶斯优化算法构建以及制作的图均使用Python 3.9完成，可从https://www.python.org/获取。
DOI: 10.6084/m9.figshare.24599001.v1
title: 集成算法在蒸散发估算中的性能及其机制

description: 数据处理、集成算法和贝叶斯优化算法构建以及制作的图均使用Python 3.9完成，可从https://www.python.org/获取。
DOI: 10.6084/m9.figshare.24599298
title: Supporting data for - Ekström et al. (2023) Impairing cardiac oxygen supply in swimming coho salmon compromises their heart function and tolerance to acute warming.xlsx

description: Supporting data for, Ekström et al (2023) Impairing cardiac oxygen supply in swimming coho salmon compromises their heart function and tolerance to acute warming. <i>Scientific Reports</i>
DOI: 10.5281/zenodo.10171750
title: FGR
DOI: 10.5281/zenodo.10171751
title: FGR
DOI: 10.20387/bonares-qz4c-56bd
title: Growth parameters, nutrient status and colonization density of beneficial microbes in winter rye grown organically and conventionally - Plant traits

description: The study focuses on the impact of a beneficial microbial consortium on the plant performance of winter rye under different farming practices during the vegetation period, including the winter growing season. Winter rye plants grown in a long-time field trial (Thy_ABS; 52°15’ N, 13°14’ E, 44 m a.s.l.)  under conventional or organic farming practices were inoculated after plant emergence in autumn 2020 with a beneficial microbial consortium containing Pseudomonas sp. (RU47, drench inoculation with 2 L per m² of 7.5 x 107 CFU mL-1), Bacillus atrophaeus (ABi03, drench inoculation with 2 L per m² of 7.5 x 107 CFU mL-1) and Trichoderma harzianum (OMG16, soil inoculation with 100 mg inoculum per m²). The density of the microbial inoculants in the rhizosphere and root-associated soil as well as the plant performance and nutrient status was quantified in autumn and the following spring. Selective plating demonstrated that the beneficial microbes successfully colonized the rhizosphere and root-associated soil of winter rye throughout its early growth cycle. The inoculation with a beneficial microbial consortium enhanced the biomass of winter rye, especially under organic farming practices at the second sampling in spring. The consortium significantly improved the nutrient status of the winter rye plants, providing an effective way to overcome nutrient limitations often found in organic farming.

Research domain: Plant Cultivation and Agricultural Technology

Research question: We hypothesized that (i) early inoculation of winter rye enables sufficient colonization of each BMc member at
early plant developmental stage, supporting its persistence in the rhizosphere throughout the vegetation period; (ii) the application of BMc shapes the composition of the rhizosphere bacterial community depending on the farming practice and thus differentially affects the plant performance.
DOI: 10.5281/zenodo.10171724
title: Dataset in R format, containing labor force data for a synthetic population
DOI: 10.5281/zenodo.10171725
title: Dataset in R format, containing labor force data for a synthetic population
DOI: 10.5281/zenodo.10160481
title: Supplementary data: "Influence of flexibility options on the German transmission grid — A sector-coupled mid-term scenario"

description: This repository contains result data for the paper  "Influence of flexibility options on the German transmission grid — A sector-coupled mid-term scenario".
The published data includes optimization results of the three main scenarios in the mentioned publication. 
The data for each scenario is stored as csv-files, which allows analysing it with many different tools. In addition, the data can be imported in Python as a network object of the open-source tool PyPSA by using the function import from csv folder . 
 
The authors thank the Federal Ministry for Economic Affairs and Climate Action for funding the research project eGon (funding code: 03EI1002).
DOI: 10.5281/zenodo.10160482
title: Supplementary data: "Influence of flexibility options on the German transmission grid — A sector-coupled mid-term scenario"

description: This repository contains result data for the paper  "Influence of flexibility options on the German transmission grid — A sector-coupled mid-term scenario".
The published data includes optimization results of the three main scenarios in the mentioned publication. 
The data for each scenario is stored as csv-files, which allows analysing it with many different tools. In addition, the data can be imported in Python as a network object of the open-source tool PyPSA by using the function import from csv folder . 
 
The authors thank the Federal Ministry for Economic Affairs and Climate Action for funding the research project eGon (funding code: 03EI1002).
DOI: 10.6084/m9.figshare.24573007.v1
title: Supplementary Material for: Response of brain and meningeal metastases to trastuzumab-deruxtecan in a patient with HER2-low breast cancer

description: Introduction: nervous system metastases (CNSm) are late events associated with poor outcomes in endocrine-sensitive HER2-negative breast cancer (BC) patients, especially in the presence of leptomeningeal disease (LMD). Effective treatments are extremely limited in this setting. The antibody-drug conjugate, trastuzumab-deruxtecan (T-DXd), which combines the anti-HER2 antibody trastuzumab with a topoisomerase type 1 inhibitor, showed high efficacy not only against HER2-positive, but also HER2-low metastatic breast cancers (BC), expressing HER2 at a lower level. Case presentation: To the best of our knowledge, this is the first report of a patient with metastatic endocrine-sensitive HER2-low BC suffering from BMs associated with LMD and sustained disease control when treated with T-DXd. Conclusion: Several recent case series have reported the activity of T-DXd in patients with HER2-positive disease and brain metastases (BMs) or leptomeningeal disease (LMD), but none in HER2-low patients. This case is particularly relevant since more than 50% of BCs are HER2-low.
DOI: 10.6092/unibo/amsacta/7403
title: INPATT (Inorganic Photochemical pATTerning): Precipitation of calcium carbonate induced by light in a perspective of micropatterning application

description: INPATT is a Proof of Concept ERC (Horizon Europe) project aimed at developing the photo-induced precipitation of calcium minerals. The main idea behind the project is that light-controlled precipitation can be achieved using molecules that release functional moieties (as carbonate or phosphate groups), which subsequently precipitate in the presence of calcium ions. The absorbance of these cleavable molecules can be tuned to the preferred wavelength and therefore, these processes can be adapted to non-invasive conditions, using aqueous solutions, bio-compatible matrices, and a non-harmful irradiation wavelength. This dataset contains characterization analysis of light induced calcium carbonate precipitates, obtained by two main techniques. The first approach, based on a previous publication (Menichetti et al, 2021, DOI:10.1002/chem.202102321), aimed to the photo-precipitation of calcium carbonate by means of Ketoprofen as photoactive molecule which was optimized to obtain a fluid paste. Secondly, calcium carbonate photo-precipitation was investigated in presence of a photocurable polymeric resin.
DOI: 10.6084/m9.figshare.24573043.v1
title: Supplementary Material for: Esophageal Infiltration by High-grade Serous Ovarian Carcinoma: A very Rare Case Report.

description: Introduction Esophageal involvement in high-grade serous ovarian carcinoma is a rare phenomenon when advanced systemic disease is detected. Dysphagia is the most common guide symptom. However, diagnosis is often delayed due to its submucosal process that is not early seen in endoscopic initial evaluation, while computerized tomography (CT) scan usually shows concentric thickening of the esophageal layers and gives the suspected diagnosis. Case presentation We present the case of a patient who died of mediastinitis caused by an esophageal perforated ulceration due to infiltration of high-grade serous ovarian carcinoma. In addition, this is the first case report of severe esophageal candidiasis associated that delayed diagnosis and subsequent oncological treatment. Conclusion Esophageal secondary infiltration must be suspected when a patient has a history of malignancy combined with consistent CT findings.
DOI: 10.6084/m9.figshare.24458920
title: Supplementary Material for: Study Design and Baseline Characteristics for Aldosterone Synthase Inhibition in CKD

description: Introduction: Aldosterone synthase (AS) inhibition may overcome increased aldosterone production in response to renin–angiotensin system inhibition. BI 690517 is an AS inhibitor under investigation for chronic kidney disease (CKD). Methods: This multinational, Phase II, double-blind study (NCT05182840) investigated the efficacy and safety of daily oral BI 690517, with or without empagliflozin 10 mg, in participants with CKD. The primary endpoint was change from baseline in urine albumin:creatinine ratio (UACR) at week 14. Between February 18, 2022, and December 30, 2022, 714 adults already treated by angiotensin-converting enzyme inhibitor (30.5%) or angiotensin receptor blocker (69.8%) were randomized (1:1) to an 8-week run-in to assign background empagliflozin (n = 356) or placebo (n = 358). Participants in each group were then randomized (1:1:1:1) to a 14-week treatment period with BI 690517 (3 mg, 10 mg, or 20 mg) or placebo. Of the 714 participants who entered run-in, 586 were randomized to the treatment period. They were predominantly men (66.6%) of White race (58.4%) with a mean (standard deviation [SD]) age of 63.8 (11.3) years. Type 2 diabetes was present in 414 participants (70.6%). The baseline mean (SD) estimated glomerular filtration rate was 51.9 (17.7) mL/min/1.73 m2 and median (interquartile range) UACR was 426.3 mg/g (205.3–888.5). Conclusion: This study will inform dose selection for further clinical development and determine whether BI 690517, with or without background empagliflozin, has a favorable safety profile and potential for additive kidney protection in participants with CKD already treated with a renin–angiotensin system inhibitor.