DOI: 10.5279/dk-sa-dda-654
title: Medfødte misdannelser i Fyns Amt, 1972-1976
title: Congenital Anomalies in the County of Funen, 1972-1976

description: Thalidomid tragedien medførte betydelig international interesse for monitorering af medfødte misdannelser. Det stigende antal fertile kvinder, der udsættes for kemiske stoffer i arbejdsmiljøet, har yderligere skærpet denne interesse.     #Ved planlægningen af et epidemiologisk overvågningssystem er der mange forskellige muligheder lige fra registre, der udelukkende er baseret på fødselsattester, til registre, der baseres på intensive interviews. De eksisterende internationale registre afspejler denne mangfoldighed af muligheder.     #Registret over medfødte anomalier i Fyns Amt blev startet bl.a. med det formål at vurdere et eventuelt registreringsdeficit ved anvendelse af enkelte indberetningskilder i forhold til at bruge al tilgængelig information i det sekundære Sundhedsvæsen.     #Alle børn født i Fyns Amt i perioden 1. april 1972 til 31. marts 1976, og som i samme tidsrum blev diagnosticeret med en eller flere misdannelser eller anomali, indgik i registret. Diagnoser fra fødselsattester, dødsattester, sygehusjournaler og en række Særforsorgsinstitutioner indgik i dataindsamlingen. Follow-up perioden blev således fra 0-4 år.     #Sygehusjournalerne viste sig at være langt den vigtigste registreringskilde. Var registret baseret udelukkende på denne indberetningskilde, ville dette have medført et tab på mindre end tre pct. af registrets nuværende bestand af børn. Langt de fleste hospitalsdiagnoser blev stillet i barnets første leveår; ekstremitetsmisdannelser, misdannelser i genitalia, hjerte og mave-tarmkanal hørte til de misdannelser, der undertiden blev registreret sent.     #Med de anvendte indgangskriterier rummer registret 3210 børn
description: The thalidomide tragedy resulted in considerable international interest in the monitoring of congenital anomalies. The increasing number of fertile women who are exposed to chemical substances in their working environment has intensified this interest even more.     #In planning an epidemiological monitoring system, many different possibilities exist, ranging from registers based exclusively on birth certificates to registers based on thorough interviews. The existing international registers reflect this multiplicity of possibilities.     #The register of congenital anomalies in the County of Funen was commenced, among other things, with the object of assessing pos- sible registration deficits when using single sources of informa- tion as compared with using all available information in the se- condary health service.     #The register comprises all children born in the County of Funen between 1 April, 1972 and 31 March, 1976 in whom one or more con- genital anomalies were diagnosed in the same period. The data material consists of diagnoses from birth certificates, death certificates, hospital case notes, and from a number of institutions under the Care of Handicapped Persons Department (Særforsorgen). Thus, the follow-up period was from 0-4 years.     #The hospital case notes proved to be by far the most important source of information. If the register had been based exclusive- ly on this source of information, the result would have been a loss of less than 3 per cent of the present number of children in the register. Most of the hospital diagnoses were arrived at during the patients' first years of life. Among the malformations which are occasionally registered rather late are: malformations in the extremities, deformities of the genitalia, of the heart, and of the gastro-intestinal canal.     #With the criteria outlined here, the register comprises 3210 children
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