cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.7291280
title: Supplementary Material for: Body Composition Is an Independent Predictor of Outcome in Patients with Hepatocellular Carcinoma Treated with Sorafenib

description: <b><i>Background:</i></b> Previous studies have suggested body composition as a predictor of sorafenib toxicity and outcome in patients with advanced hepatocellular carcinoma (HCC). Large studies on the impact of body composition parameters in European HCC patients are lacking. Our aim was to validate the prognostic value of body composition parameters in Dutch patients with HCC treated with sorafenib. <b><i>Patients and Methods:</i></b> A retrospective analysis was performed in a cohort of HCC patients treated with sorafenib at two Dutch tertiary referral centers between 2007 and 2016. Body composition (adipose and skeletal muscle tissue) was measured at baseline by computed tomography (CT). Low skeletal muscle mass (SMM) and density were defined using published cut-offs. Body composition parameters were correlated with overall survival (OS), time to progression, response rate, and toxicity. <b><i>Results:</i></b> A total of 278 patients were included, mostly Child-Pugh class A (85%) and Barcelona Clinic Liver Cancer (BCLC) stage C (73%), with a median OS of 9.5 months (95% CI 8.1–11.0). Patients with combined low SMM and low total adipose tissue index (TATI) (<i>n</i> = 68, 25%) had a poor median OS (5.8, 95% CI 4.8–6.8) compared with other patients (11.7, 95% CI 9.4–14.0). Combined low SMM and low TATI remained an independent predictor of OS (HR 1.56, 95% CI 1.15–2.11, <i>p</i> = 0.004) after adjusting for known prognostic factors. There was no association between body composition and sorafenib toxicity. <b><i>Conclusions:</i></b> In Dutch HCC patients treated with sorafenib, the combined presence of low SMM and low TATI was associated with impaired survival, independent of known prognostic factors. CT assessment of body composition may provide additional prognostic information prior to sorafenib treatment.
DOI: 10.6084/m9.figshare.7291358.v1
title: Le Bel Amiens Du Tissage Delruy (The “Bel Amiens” of Delruy Textile)

description: In the former beguinage of the Vidame district, not far from the Somme River near La Hotoie garden, Strock's mechanical arts and industries and Fernand Delruy fabrics sum up more than a hundred years of life at the rhythm of the workshops. The urban geography of Carré Delruy 20-24 Boulevard du Port tells the story of the city of Amiens.French Abstract: Dans l’ancien béguinage du quartier du Vidame, pas très loin de la Somme près de la Hotoie, des arts et industries de la mécanique Strock et des tissus Fernand Delruy résument plus de cent ans de vie au rythme des ateliers. Un savoir-faire qui raconte l’histoire de la ville d’Amiens à travers la géographie urbaine du Carré Delruy du 20-24 Boulevard du Port. <br>
DOI: 10.7284/105567
title: TSG (Thermosalinograph) data collected during research cruise SAV-11-39 using a Sea-Bird SBE-21 instrument system onboard the platform RV Savannah

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7291280.v1
title: Supplementary Material for: Body Composition Is an Independent Predictor of Outcome in Patients with Hepatocellular Carcinoma Treated with Sorafenib

description: <b><i>Background:</i></b> Previous studies have suggested body composition as a predictor of sorafenib toxicity and outcome in patients with advanced hepatocellular carcinoma (HCC). Large studies on the impact of body composition parameters in European HCC patients are lacking. Our aim was to validate the prognostic value of body composition parameters in Dutch patients with HCC treated with sorafenib. <b><i>Patients and Methods:</i></b> A retrospective analysis was performed in a cohort of HCC patients treated with sorafenib at two Dutch tertiary referral centers between 2007 and 2016. Body composition (adipose and skeletal muscle tissue) was measured at baseline by computed tomography (CT). Low skeletal muscle mass (SMM) and density were defined using published cut-offs. Body composition parameters were correlated with overall survival (OS), time to progression, response rate, and toxicity. <b><i>Results:</i></b> A total of 278 patients were included, mostly Child-Pugh class A (85%) and Barcelona Clinic Liver Cancer (BCLC) stage C (73%), with a median OS of 9.5 months (95% CI 8.1–11.0). Patients with combined low SMM and low total adipose tissue index (TATI) (<i>n</i> = 68, 25%) had a poor median OS (5.8, 95% CI 4.8–6.8) compared with other patients (11.7, 95% CI 9.4–14.0). Combined low SMM and low TATI remained an independent predictor of OS (HR 1.56, 95% CI 1.15–2.11, <i>p</i> = 0.004) after adjusting for known prognostic factors. There was no association between body composition and sorafenib toxicity. <b><i>Conclusions:</i></b> In Dutch HCC patients treated with sorafenib, the combined presence of low SMM and low TATI was associated with impaired survival, independent of known prognostic factors. CT assessment of body composition may provide additional prognostic information prior to sorafenib treatment.
DOI: 10.7284/105668
title: ADCP (Acoustic Doppler Current Profiler) data collected during research cruise SAV-11-40 using a RDI WM-300 instrument system onboard the platform RV Savannah

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/105605
title: CTD (Conductivity, Temperature, Depth) data collected during research cruise SAV-11-40 using a Sea-Bird SBE-25 instrument system onboard the platform RV Savannah

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/105482
title: GNSS (Global Navigation Satellite System) data collected during research cruise SAV-11-40 using a Furuno GP-90 instrument system onboard the platform RV Savannah

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7291238
title: Supplementary Table from Insights into the roles of CMK-1 and OGT-1 in interstimulus interval-dependent habituation in <i>Caenorhabditis elegans</i>

description: Habituation is a ubiquitous form of non-associative learning observed as a decrement in responding to repeated stimulation that cannot be explained by sensory adaptation or motor fatigue. One of the defining characteristics of habituation is its sensitivity to the rate at which training stimuli are presented—animals habituate faster in response to more rapid stimulation. The molecular mechanisms underlying this interstimulus interval (ISI)-dependent characteristic of habituation remain unknown. In this article, we use behavioural neurogenetic and bioinformatic analyses in the nematode <i>Caenorhabiditis elegans</i> to identify the first molecules that modulate habituation in an ISI-dependent manner. We show that the <i>Caenorhabditis elegans</i> orthologues of Ca<sup>2+</sup>/calmodulin-dependent kinases CaMK1/4, CMK-1 and O-linked N-acetylglucosamine (O-GlcNAc) transferase, OGT-1, both function in primary sensory neurons to inhibit habituation at short ISIs and promote it at long ISIs. In addition, both <i>cmk-1</i> and <i>ogt-1</i> mutants display a rare mechanosensory hyper-responsive phenotype, i.e. larger mechanosensory responses than wild-type. Overall, our work identifies two conserved genes that function in sensory neurons to modulate habituation in an ISI-dependent manner, providing the first insights into the molecular mechanisms underlying the universally observed phenomenon that habituation has different properties when stimuli are delivered at different rates.
DOI: 10.6084/m9.figshare.7291238.v1
title: Supplementary Table from Insights into the roles of CMK-1 and OGT-1 in interstimulus interval-dependent habituation in <i>Caenorhabditis elegans</i>

description: Habituation is a ubiquitous form of non-associative learning observed as a decrement in responding to repeated stimulation that cannot be explained by sensory adaptation or motor fatigue. One of the defining characteristics of habituation is its sensitivity to the rate at which training stimuli are presented—animals habituate faster in response to more rapid stimulation. The molecular mechanisms underlying this interstimulus interval (ISI)-dependent characteristic of habituation remain unknown. In this article, we use behavioural neurogenetic and bioinformatic analyses in the nematode <i>Caenorhabiditis elegans</i> to identify the first molecules that modulate habituation in an ISI-dependent manner. We show that the <i>Caenorhabditis elegans</i> orthologues of Ca<sup>2+</sup>/calmodulin-dependent kinases CaMK1/4, CMK-1 and O-linked N-acetylglucosamine (O-GlcNAc) transferase, OGT-1, both function in primary sensory neurons to inhibit habituation at short ISIs and promote it at long ISIs. In addition, both <i>cmk-1</i> and <i>ogt-1</i> mutants display a rare mechanosensory hyper-responsive phenotype, i.e. larger mechanosensory responses than wild-type. Overall, our work identifies two conserved genes that function in sensory neurons to modulate habituation in an ISI-dependent manner, providing the first insights into the molecular mechanisms underlying the universally observed phenomenon that habituation has different properties when stimuli are delivered at different rates.
DOI: 10.7284/105648
title: Gyrocompass data collected during research cruise SAV-11-40 using a Yokogawa CMZ700B instrument system onboard the platform RV Savannah

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/105525
title: Meteorological Station data collected during research cruise SAV-11-40 using a RM Young 26800 instrument system onboard the platform RV Savannah

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/105710
title: Singlebeam Echosounder data collected during research cruise SAV-11-40 using a Furuno FCV-582 instrument system onboard the platform RV Savannah

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7291220
title: Supplementary Material for: Increased Energy Expenditure, Lipolysis and Hyperinsulinemia Confer Resistance to Central Obesity and Type 2 Diabetes in Mice Lacking Alpha2α-Adrenoceptors

description: The alpha2A-adrenoceptors (α<sub>2A</sub>-ARs) are Gi-coupled receptors, which prejunctionally inhibit the release of norepinephrine (NE) and epinephrine (Epi), and postjunctionally inhibit insulin secretion and lipolysis. We have earlier shown that α<sub>2A</sub><sup>–/–</sup> mice display sympathetic hyperactivity, hyperinsulinemia and improved glucose tolerance. Here we employed α<sub>2A</sub><sup>–/–</sup> mice and placed the mice on a high-fat diet (HFD) to test the hypothesis that lack of α<sub>2A</sub>-ARs protects from diet-induced obesity and type 2 diabetes (T2D). In addition, a high-caloric diet was combined with running wheel exercise to test the interaction of diet and exercise. HFD was obesogenic in both genotypes, but α<sub>2A</sub><sup>–/–</sup> mice accumulated less visceral fat than the wild-type controls, were protected from T2D, and their insulin secretion was unaltered by the diet. Lack of α<sub>2A</sub>-ARs is associated with an increased sympatho-adrenal tone, which resulted in increased energy expenditure and fat oxidation rate potentiated by HFD. Fittingly, α<sub>2A</sub><sup>–/–</sup> mice displayed enhanced lipolytic responses to Epi, and increased faecal lipids suggesting altered fat mobilization and absorption. Subcutaneous white fat appeared to be thermogenically more active (measured as <i>Ucp1</i> mRNA expression) in α<sub>2A</sub><sup>–/–</sup> mice, and brown fat showed an increased response to NE. Exercise was effective in reducing total body adiposity and increasing lean mass in both genotypes, but there was a significant diet-genotype interaction, as even modestly increased physical activity combined with lack of α<sub>2A</sub>-AR signalling promoted weight loss more efficiently than exercise with normal α<sub>2A</sub>-AR function. These results suggest that blockade of α<sub>2A</sub>-ARs may be exploited to reduce visceral fat and to improve insulin secretion.
DOI: 10.6084/m9.figshare.7291220.v1
title: Supplementary Material for: Increased Energy Expenditure, Lipolysis and Hyperinsulinemia Confer Resistance to Central Obesity and Type 2 Diabetes in Mice Lacking Alpha2α-Adrenoceptors

description: The alpha2A-adrenoceptors (α<sub>2A</sub>-ARs) are Gi-coupled receptors, which prejunctionally inhibit the release of norepinephrine (NE) and epinephrine (Epi), and postjunctionally inhibit insulin secretion and lipolysis. We have earlier shown that α<sub>2A</sub><sup>–/–</sup> mice display sympathetic hyperactivity, hyperinsulinemia and improved glucose tolerance. Here we employed α<sub>2A</sub><sup>–/–</sup> mice and placed the mice on a high-fat diet (HFD) to test the hypothesis that lack of α<sub>2A</sub>-ARs protects from diet-induced obesity and type 2 diabetes (T2D). In addition, a high-caloric diet was combined with running wheel exercise to test the interaction of diet and exercise. HFD was obesogenic in both genotypes, but α<sub>2A</sub><sup>–/–</sup> mice accumulated less visceral fat than the wild-type controls, were protected from T2D, and their insulin secretion was unaltered by the diet. Lack of α<sub>2A</sub>-ARs is associated with an increased sympatho-adrenal tone, which resulted in increased energy expenditure and fat oxidation rate potentiated by HFD. Fittingly, α<sub>2A</sub><sup>–/–</sup> mice displayed enhanced lipolytic responses to Epi, and increased faecal lipids suggesting altered fat mobilization and absorption. Subcutaneous white fat appeared to be thermogenically more active (measured as <i>Ucp1</i> mRNA expression) in α<sub>2A</sub><sup>–/–</sup> mice, and brown fat showed an increased response to NE. Exercise was effective in reducing total body adiposity and increasing lean mass in both genotypes, but there was a significant diet-genotype interaction, as even modestly increased physical activity combined with lack of α<sub>2A</sub>-AR signalling promoted weight loss more efficiently than exercise with normal α<sub>2A</sub>-AR function. These results suggest that blockade of α<sub>2A</sub>-ARs may be exploited to reduce visceral fat and to improve insulin secretion.
DOI: 10.6084/m9.figshare.7291217
title: Collection of Class corpora

description: zip containing all corpora for the files contained in the projects sampled for the EMSE paper
DOI: 10.7284/105568
title: TSG (Thermosalinograph) data collected during research cruise SAV-11-40 using a Sea-Bird SBE-21 instrument system onboard the platform RV Savannah

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7291184
title: Supplementary Material for: Patient Satisfaction and Clinical Outcomes with Budesonide plus Formoterol Spiromax for Asthma and Chronic Obstructive Pulmonary Disease: A Real-World, Observational Trial

description: <b><i>Background:</i></b> The fixed-dose combination of budesonide/formoterol (B/F) has been available in the Spiromax® dry powder inhaler since 2014. <b><i>Objectives:</i></b> To assess patient satisfaction, inhaler use errors, and disease control in patients with asthma or chronic obstructive pulmonary disease (COPD) treated with B/F Spiromax. <b><i>Methods:</i></b> This non-interventional, prospective, 12-week study enrolled consecutive asthma or COPD patients who had recently begun treatment with B/F Spiromax or were switched from another inhaled corticosteroid/long-acting β<sub>2</sub>-agonist combination to B/F Spiromax in routine clinical practice. Patients recruited from 243 specialist respiratory clinics or general practices in Germany were assessed for patient satisfaction (Satisfaction with Inhalers and Preference questionnaire), inhaler application errors (modified Easy Low Instruction over Time checklist), disease control, and safety. <b><i>Results:</i></b> The population included 3,943 patients: asthma <i>n</i> = 2,707 (68.7%); COPD <i>n</i> = 1,236 (31.3%). At baseline, 60.1% of patients were “satisfied” or “very satisfied” with their previous inhaler, and this increased to 88.8% at week 12 of B/F Spiromax use. Overall, 62.1% of pre-treated patients preferred B/F Spiromax to their old inhaler. The frequency of any handling error observed with B/F Spiromax at week 12 was lower than at baseline (11.9 vs. 25.5% of patients, respectively). After 12 weeks, 77.4% were assessed as having improved (minimally, much, or very much) overall health status versus baseline. Guideline-defined disease severity (as rated by physicians) and patient-reported symptom severity improved during the study in both asthma and COPD patients. B/F Spiromax was well tolerated. <b><i>Conclusion:</i></b> B/F Spiromax was associated with high patient satisfaction, low device handling error rate, and improvements in clinical outcomes in real-world clinical practice.
DOI: 10.6084/m9.figshare.7291217.v1
title: Collection of Class corpora

description: zip containing all corpora for the files contained in the projects sampled for the EMSE paper
DOI: 10.6084/m9.figshare.7291175
title: CVSAnalY database

description: dump of the CVSAnalY database for computation of results of developers metadata
DOI: 10.7284/105483
title: GNSS (Global Navigation Satellite System) data collected during research cruise SAV-11-41 using a Furuno GP-90 instrument system onboard the platform RV Savannah

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7291175.v1
title: CVSAnalY database

description: dump of the CVSAnalY database for computation of results of developers metadata
DOI: 10.7284/105484
title: GNSS (Global Navigation Satellite System) data collected during research cruise SAV-11-42 using a Furuno GP-90 instrument system onboard the platform RV Savannah

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/105485
title: GNSS (Global Navigation Satellite System) data collected during research cruise SAV-11-43 using a Furuno GP-90 instrument system onboard the platform RV Savannah

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7291115
title: Supplementary Material for: Abnormal Illness Behavior, Alexithymia, Demoralization, and Other Clinically Relevant Psychosocial Syndromes in Kidney Transplant Recipients: A Comparative Study of the Diagnostic Criteria for Psychosomatic Research System versus ICD-10 Psychiatric Nosology

description: Medicine
DOI: 10.6084/m9.figshare.7291115.v1
title: Supplementary Material for: Abnormal Illness Behavior, Alexithymia, Demoralization, and Other Clinically Relevant Psychosocial Syndromes in Kidney Transplant Recipients: A Comparative Study of the Diagnostic Criteria for Psychosomatic Research System versus ICD-10 Psychiatric Nosology

description: Medicine
DOI: 10.7284/105671
title: ADCP (Acoustic Doppler Current Profiler) data collected during research cruise SAV-11-44 using a RDI WM-300 instrument system onboard the platform RV Savannah

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/105609
title: CTD (Conductivity, Temperature, Depth) data collected during research cruise SAV-11-44 using a Sea-Bird SBE-25 instrument system onboard the platform RV Savannah

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/105486
title: GNSS (Global Navigation Satellite System) data collected during research cruise SAV-11-44 using a Furuno GP-90 instrument system onboard the platform RV Savannah

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/105652
title: Gyrocompass data collected during research cruise SAV-11-44 using a Yokogawa CMZ700B instrument system onboard the platform RV Savannah

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7291085
title: Raw_data.zip

description: Raw GPS location fixes of four African wild dog individuals in the Limpopo and Mpumalanga provinces in South Africa. Data were collected from collared individuals from 2012 to 2014. the Skukuza and Opren individuals occurred within the Kruger National Park, whilst the Bluebank and Waterberg individuals occurred outside the boundaries of the park.
DOI: 10.6084/m9.figshare.7291088
title: Estimated annual and lifetime labor productivity in the United States, 2016: implications for economic evaluations

description: <b>Background:</b> Human-capital based lifetime productivity estimates are frequently used in cost-of-illness (COI) analyses and, less commonly, in cost-effectiveness analyses (CEAs). Previous US estimates assumed that labor productivity and real earnings both grow by 1% per year. <b>Objectives:</b> This study presents estimates of annual and lifetime productivity for 2016 using data from the American Community Survey, the American Time Use Survey, and the Current Population Survey, and with varying assumptions about real earnings growth. <b>Methods:</b> The sum of market productivity (gross annual personal labor earnings adjusted for employer-paid benefits) and the imputed value of non-market time spent in household, caring, and volunteer services was estimated. The present value of lifetime productivity at various ages was calculated for synthetic cohorts using annual productivity estimates, life tables, discount rates, and assumptions about future earnings growth rates. <b>Results:</b> Mean annual productivity was $57,324 for US adults in 2016, including $36,935 in market and $20,389 in non-market productivity. Lifetime productivity at birth, using a 3% discount rate, is roughly $1.5 million if earnings grow by 1% per year and $1.2 million if future earnings growth averages 0.5% per year. <b>Conclusions:</b> Inclusion of avoidable productivity losses in societal-perspective CEAs of health interventions is recommended in new US cost-effectiveness guidelines. However, estimates vary depending on whether analysts choose to estimate total productivity or just market productivity, and on assumptions made about growth in future productivity and earnings.
DOI: 10.6084/m9.figshare.7291088.v1
title: Estimated annual and lifetime labor productivity in the United States, 2016: implications for economic evaluations

description: <b>Background:</b> Human-capital based lifetime productivity estimates are frequently used in cost-of-illness (COI) analyses and, less commonly, in cost-effectiveness analyses (CEAs). Previous US estimates assumed that labor productivity and real earnings both grow by 1% per year. <b>Objectives:</b> This study presents estimates of annual and lifetime productivity for 2016 using data from the American Community Survey, the American Time Use Survey, and the Current Population Survey, and with varying assumptions about real earnings growth. <b>Methods:</b> The sum of market productivity (gross annual personal labor earnings adjusted for employer-paid benefits) and the imputed value of non-market time spent in household, caring, and volunteer services was estimated. The present value of lifetime productivity at various ages was calculated for synthetic cohorts using annual productivity estimates, life tables, discount rates, and assumptions about future earnings growth rates. <b>Results:</b> Mean annual productivity was $57,324 for US adults in 2016, including $36,935 in market and $20,389 in non-market productivity. Lifetime productivity at birth, using a 3% discount rate, is roughly $1.5 million if earnings grow by 1% per year and $1.2 million if future earnings growth averages 0.5% per year. <b>Conclusions:</b> Inclusion of avoidable productivity losses in societal-perspective CEAs of health interventions is recommended in new US cost-effectiveness guidelines. However, estimates vary depending on whether analysts choose to estimate total productivity or just market productivity, and on assumptions made about growth in future productivity and earnings.