cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.12206051
title: Amplified centrosomes may underlie aggressive disease course in pancreatic ductal adenocarcinoma

description: Centrosome amplification (CA), the presence of centrosomes that are abnormally numerous or enlarged, is a well-established driver of tumor initiation and progression associated with poor prognosis across a diversity of malignancies. Pancreatic ductal adenocarcinoma (PDAC) carries one of the most dismal prognoses of all cancer types. A majority of these tumors are characterized by numerical and structural centrosomal aberrations, but it is unknown how CA contributes to the disease and patient outcomes. In this study, we sought to determine whether CA was associated with worse clinical outcomes, poor prognostic indicators, markers of epithelial-mesenchymal transition (EMT), and ethnicity in PDAC. We also evaluated whether CA could precipitate more aggressive phenotypes in a panel of cultured PDAC cell lines. Using publicly available microarray data, we found that increased expression of genes whose dysregulation promotes CA was associated with worse overall survival and increased EMT marker expression in PDAC. Quantitative analysis of centrosomal profiles in PDAC cell lines and tissue sections uncovered varying levels of CA, and the expression of CA markers was associated with the expression of EMT markers. We induced CA in PDAC cells and found that CA empowered them with enhanced invasive and migratory capabilities. In addition, we discovered that PDACs from African American (AA) patients exhibited a greater extent of both numerical and structural CA than PDACs from European American (EA) patients. Taken together, these findings suggest that CA may fuel a more aggressive disease course in PDAC patients.
DOI: 10.6084/m9.figshare.12206051.v1
title: Amplified centrosomes may underlie aggressive disease course in pancreatic ductal adenocarcinoma

description: Centrosome amplification (CA), the presence of centrosomes that are abnormally numerous or enlarged, is a well-established driver of tumor initiation and progression associated with poor prognosis across a diversity of malignancies. Pancreatic ductal adenocarcinoma (PDAC) carries one of the most dismal prognoses of all cancer types. A majority of these tumors are characterized by numerical and structural centrosomal aberrations, but it is unknown how CA contributes to the disease and patient outcomes. In this study, we sought to determine whether CA was associated with worse clinical outcomes, poor prognostic indicators, markers of epithelial-mesenchymal transition (EMT), and ethnicity in PDAC. We also evaluated whether CA could precipitate more aggressive phenotypes in a panel of cultured PDAC cell lines. Using publicly available microarray data, we found that increased expression of genes whose dysregulation promotes CA was associated with worse overall survival and increased EMT marker expression in PDAC. Quantitative analysis of centrosomal profiles in PDAC cell lines and tissue sections uncovered varying levels of CA, and the expression of CA markers was associated with the expression of EMT markers. We induced CA in PDAC cells and found that CA empowered them with enhanced invasive and migratory capabilities. In addition, we discovered that PDACs from African American (AA) patients exhibited a greater extent of both numerical and structural CA than PDACs from European American (EA) patients. Taken together, these findings suggest that CA may fuel a more aggressive disease course in PDAC patients.
DOI: 10.21954/ou.rd.12205712
title: Security in the World

description: This is a card-based discussion activity. It relates different views of real-world security incidents to participants' own values and experiences. This workshop creates a safe space for participants to explore the impact of cyber security attacks on companies and individuals.
DOI: 10.21954/ou.rd.12205712.v1
title: Security in the World

description: This is a card-based discussion activity. It relates different views of real-world security incidents to participants' own values and experiences. This workshop creates a safe space for participants to explore the impact of cyber security attacks on companies and individuals.
DOI: 10.6084/m9.figshare.12205652
title: VCF file almond: 156ind_x_209257sites

description: Unfiltered SNP variants of 156 almond accessions in VCF v4.2 format. For details on SNP calling and filtering, please see M&M of the manuscript titled: "Genome-wide characterization of almond diversity/homozygosity defines structure, kinship, inbreeding and linkage disequilibrium in cultivated germplasm and reveals genetic associations with nut and seed weight".
DOI: 10.6084/m9.figshare.12205631
title: f1000 Extended data ( Phytochemistry and Phytopharmacology of 5 Medicinal Weeds)

description: extended research data
DOI: 10.17633/rd.brunel.12205511
title: Family planning study 3

description: The same selection criteria were imposed with Study 3 as described in Studies 1 and 2 (separate datasets in this project), but recruited from a general internet sample (with participation facilitated through Qualtrics Panels), yielding a total sample size of 210. Participants received financial incentives for their participation (approx. $5), and the average age of the participants was 30 years (<i>SD</i> = 7.74). The current sample was predominantly female (80%), White/Non-Hispanic (61.9%), heterosexual (81.4%), and involved in a romantic relationship (dating = 19%; engaged = 2.4%; married = 21%).
DOI: 10.17633/rd.brunel.12205487
title: Family planning study 2

description: Study 2 used the same selection criteria as described in Study 1 (other published file in this project) and obtained a sample of 189 participants with an average age of 20 years (<i>SD</i> = 2.42). This sample consisted entirely of college students (consistent with Griskevicius, et al, 2007; 2011) enrolled in a small southeastern University and compensated with course credit for their participation. Participant recruitment was through SONA and participation was facilitated through Qualtrics online survey software. The current sample was predominantly female (79.4%), White/Non-Hispanic (74.1%), heterosexual (91%), and involved in a romantic relationship (51.3%).
DOI: 10.17633/rd.brunel.12205487.v1
title: Family planning study 2

description: Study 2 used the same selection criteria as described in Study 1 (other published file in this project) and obtained a sample of 189 participants with an average age of 20 years (<i>SD</i> = 2.42). This sample consisted entirely of college students (consistent with Griskevicius, et al, 2007; 2011) enrolled in a small southeastern University and compensated with course credit for their participation. Participant recruitment was through SONA and participation was facilitated through Qualtrics online survey software. The current sample was predominantly female (79.4%), White/Non-Hispanic (74.1%), heterosexual (91%), and involved in a romantic relationship (51.3%).
DOI: 10.6084/m9.figshare.12205379
title: Metadata record for: Global high-resolution emissions of soil NOx, sea salt aerosols, and biogenic volatile organic compounds

description: This dataset contains key characteristics about the data described in the Data Descriptor Global high-resolution emissions of soil NOx, sea salt aerosols, and biogenic volatile organic compounds. <br> Contents: <br> 1. human readable metadata summary table in CSV format 2. machine readable metadata file in JSON format
DOI: 10.17633/rd.brunel.12205409
title: Family planning study 1

description: Because prior parenting experiences (e.g., parity, the sex of current children) often change individuals’ fertility intentions (Balbo, Billari, & Mills, 2013), this work focused exclusively on fertility decision-making practices of childless individuals. The sample was also limited to individuals of reproductively viable age; defined as ages 18-45 (see Toulemon & Testa, 2005). The current work obtained an internet-based sample of 241 participants, with an average age of 22 years (<i>SD</i> = 5.33), through both general population and university sources (Mechanical Turk, N = 80; SONA [university students], N = 55; Reddit, N = 106). All participation was via Qualtrics software. Thirty-five participants indicated that they were parents and were therefore excluded from further analysis (resulting in N = 206). Mechanical Turk participants were compensated 25 cents for their participation, SONA participants were enrolled in a large Midwestern University and compensated with course credit for their participation, and Reddit participants did not receive any compensation for their participation. The current sample was predominantly female (59.7%), White/Non-Hispanic (80.6%), heterosexual (87.4%), and involved in a romantic relationship (46.6%).
DOI: 10.6084/m9.figshare.12205379.v1
title: Metadata record for: Global high-resolution emissions of soil NOx, sea salt aerosols, and biogenic volatile organic compounds

description: This dataset contains key characteristics about the data described in the Data Descriptor Global high-resolution emissions of soil NOx, sea salt aerosols, and biogenic volatile organic compounds. <br> Contents: <br> 1. human readable metadata summary table in CSV format 2. machine readable metadata file in JSON format
DOI: 10.6084/m9.figshare.12205346
title: Evaluation of honey quality of Northeast of Brazil: botanical origin and heavy metals content

description: A chemical and palynological study was performed on honey of <i>Apis mellifera</i> L. (Hymenoptera: Apidae) produced and marketed in the nine states that comprise the Northeast Region of Brazil. A total of 58 samples were obtained from markets between the years 2015 and 2017. The pollen spectra of the samples encompassed 232 pollen types of defined botanical origin, with 31 samples possessing predominant pollen in their spectra, which represent species with beekeeping potential: <i>Angelonia</i>, <i>Borreria verticillata</i>, <i>Copaifera</i>, <i>Mimosa caesalpiniifolia</i>, <i>M. pudica</i>, <i>M. tenuiflora</i>, <i>Myrcia</i> 1, <i>Schinus terebinthifolia</i>, <i>Tapirira guianensis</i>, <i>Tarenaya</i>, and <i>Ziziphus joazeiro</i>. Leguminosae was the most represented botanical family in all the studied honey samples, with <i>Mimosa</i> L. being the most diverse and frequent genus. The richness of different pollen types varied among states, but similarities in pollen spectra were minimally related to geographical proximity to the municipalities of origin. Thus, some pollen types, alone or in combination, can be considered good indicators of honey produced in Northeast Brazil. The levels of the main metallic contaminants of honey (i.e., As, Cd, Cr, Hg, and Pb) were found to be below their respective limits, suggesting that honey samples from the Northeast are safe for human consumption. The studied samples presented heterogeneous botanical constitutions that reflect the diversity of plant species of the Caatinga biome and the generalist habit of <i>A. mellifera</i>.
DOI: 10.6084/m9.figshare.12205313
title: Supplementary data .docx

description: supplementary data
DOI: 10.6084/m9.figshare.12205346.v1
title: Evaluation of honey quality of Northeast of Brazil: botanical origin and heavy metals content

description: A chemical and palynological study was performed on honey of <i>Apis mellifera</i> L. (Hymenoptera: Apidae) produced and marketed in the nine states that comprise the Northeast Region of Brazil. A total of 58 samples were obtained from markets between the years 2015 and 2017. The pollen spectra of the samples encompassed 232 pollen types of defined botanical origin, with 31 samples possessing predominant pollen in their spectra, which represent species with beekeeping potential: <i>Angelonia</i>, <i>Borreria verticillata</i>, <i>Copaifera</i>, <i>Mimosa caesalpiniifolia</i>, <i>M. pudica</i>, <i>M. tenuiflora</i>, <i>Myrcia</i> 1, <i>Schinus terebinthifolia</i>, <i>Tapirira guianensis</i>, <i>Tarenaya</i>, and <i>Ziziphus joazeiro</i>. Leguminosae was the most represented botanical family in all the studied honey samples, with <i>Mimosa</i> L. being the most diverse and frequent genus. The richness of different pollen types varied among states, but similarities in pollen spectra were minimally related to geographical proximity to the municipalities of origin. Thus, some pollen types, alone or in combination, can be considered good indicators of honey produced in Northeast Brazil. The levels of the main metallic contaminants of honey (i.e., As, Cd, Cr, Hg, and Pb) were found to be below their respective limits, suggesting that honey samples from the Northeast are safe for human consumption. The studied samples presented heterogeneous botanical constitutions that reflect the diversity of plant species of the Caatinga biome and the generalist habit of <i>A. mellifera</i>.
DOI: 10.6084/m9.figshare.12205274
title: Metadata record for: Large database for the analysis and prediction of spliced and non-spliced peptide generation by proteasomes

description: This dataset contains key characteristics about the data described in the Data Descriptor Large database for the analysis and prediction of spliced and non-spliced peptide generation by proteasomes. <br> Contents: <br> 1. human readable metadata summary table in CSV format 2. machine readable metadata file in JSON format <br> <br> <br>
DOI: 10.6084/m9.figshare.12205265
title: data_covid.xlsx

description: Ecological survival analysis of COVID-19 spread
DOI: 10.6084/m9.figshare.12205265.v1
title: data_covid.xlsx

description: Ecological survival analysis of COVID-19 spread
DOI: 10.6084/m9.figshare.12205274.v1
title: Metadata record for: Large database for the analysis and prediction of spliced and non-spliced peptide generation by proteasomes

description: This dataset contains key characteristics about the data described in the Data Descriptor Large database for the analysis and prediction of spliced and non-spliced peptide generation by proteasomes. <br> Contents: <br> 1. human readable metadata summary table in CSV format 2. machine readable metadata file in JSON format <br> <br> <br>
DOI: 10.6084/m9.figshare.12205232
title: ModelSimulation_0.56deg_no2_Modellevel_2hourly_20080629-20080721.nc

description: Model simulation output of NO2 concentration
DOI: 10.6084/m9.figshare.12205232.v1
title: ModelSimulation_0.56deg_no2_Modellevel_2hourly_20080629-20080721.nc

description: Model simulation output of NO2 concentration
DOI: 10.6084/m9.figshare.12205178
title: Mechanism of Paleoarchean continental crust formation as archived in granitoids from northern part of Singhbhum Craton, eastern India

description: Supplemental Table 3: Trace element compositions of zircon grains from granitoids of Saraikela–Hata area, Singhbhum Craton
DOI: 10.6084/m9.figshare.12205178.v1
title: Mechanism of Paleoarchean continental crust formation as archived in granitoids from northern part of Singhbhum Craton, eastern India

description: Supplemental Table 3: Trace element compositions of zircon grains from granitoids of Saraikela–Hata area, Singhbhum Craton
DOI: 10.6084/m9.figshare.12205166
title: Mechanism of Paleoarchean continental crust formation as archived in granitoids from northern part of Singhbhum Craton, eastern India

description: Supplemental Table 4: Lu–Hf isotope compositions of zircon grains of granitoids from Saraikela–Hata area, Singhbhum Craton
DOI: 10.6084/m9.figshare.12205169
title: Mechanism of Paleoarchean continental crust formation as archived in granitoids from northern part of Singhbhum Craton, eastern India

description: Supplemental Table 2: U–Pb–Th isotope analyses and ages of zircon grains from granitoids of Saraikela–Hata area, Singhbhum Craton and zircon standard GJ-1
DOI: 10.6084/m9.figshare.12205169.v1
title: Mechanism of Paleoarchean continental crust formation as archived in granitoids from northern part of Singhbhum Craton, eastern India

description: Supplemental Table 2: U–Pb–Th isotope analyses and ages of zircon grains from granitoids of Saraikela–Hata area, Singhbhum Craton and zircon standard GJ-1
DOI: 10.6084/m9.figshare.12205163
title: Mechanism of Paleoarchean continental crust formation as archived in granitoids from northern part of Singhbhum Craton, eastern India

description: Supplemental Table 1: Major and trace element compositions of geochemical reference materials (analyzed as unknowns with granitoid samples fron Hata–Saraikela area, Singhbhum Craton) and duplicate samples
DOI: 10.6084/m9.figshare.12205160
title: Mechanism of Paleoarchean continental crust formation as archived in granitoids from northern part of Singhbhum Craton, eastern India

description: Supplemental Table 5: Electron microprobe analyses (wt%) of ampbiboles from the Saraikela gneiss (163A)
DOI: 10.6084/m9.figshare.12205160.v1
title: Mechanism of Paleoarchean continental crust formation as archived in granitoids from northern part of Singhbhum Craton, eastern India

description: Supplemental Table 5: Electron microprobe analyses (wt%) of ampbiboles from the Saraikela gneiss (163A)
DOI: 10.6084/m9.figshare.12205163.v1
title: Mechanism of Paleoarchean continental crust formation as archived in granitoids from northern part of Singhbhum Craton, eastern India

description: Supplemental Table 1: Major and trace element compositions of geochemical reference materials (analyzed as unknowns with granitoid samples fron Hata–Saraikela area, Singhbhum Craton) and duplicate samples
DOI: 10.6084/m9.figshare.12205118
title: Matt-task-spatcue-half.bdf

description: A BDF data file for use with eegUtils
DOI: 10.6084/m9.figshare.12205118.v1
title: Matt-task-spatcue-half.bdf

description: A BDF data file for use with eegUtils
DOI: 10.6084/m9.figshare.12205055
title: Tree_44_9PCG & 11AA

description: IQ treeBayesPhylobayes
DOI: 10.6084/m9.figshare.12205055.v1
title: Tree_44_9PCG & 11AA

description: IQ treeBayesPhylobayes
DOI: 10.6084/m9.figshare.12205022
title: Bankit

description: SqnBiosample tableSRA tableCOI sequence
DOI: 10.6084/m9.figshare.12205025
title: Data Matrix_44_9PCG & 11AA

description: 44 taxa 9PCG & 11AAaligned with mafftConcatenate with Phylosuite
DOI: 10.6084/m9.figshare.12205034
title: Sequence Assembly and Base composition

description: Assembly note including failure of CR Base composition table
DOI: 10.6084/m9.figshare.12205025.v1
title: Data Matrix_44_9PCG & 11AA

description: 44 taxa 9PCG & 11AAaligned with mafftConcatenate with Phylosuite
DOI: 10.6084/m9.figshare.12204959
title: Saturation

description: AA saturationPCGs_N saturation
DOI: 10.6084/m9.figshare.12205034.v2
title: Sequence Assembly and Base composition

description: Assembly note including failure of CR Base composition table
DOI: 10.6084/m9.figshare.12204959.v1
title: Saturation

description: AA saturationPCGs_N saturation
DOI: 10.6084/m9.figshare.12205034.v1
title: Sequence Assembly and Base composition

description: Assembly note including failure of CR Base composition table
DOI: 10.6084/m9.figshare.12204899
title: guppy laterality data from Consistency in the strength of laterality in male, but not female, guppies across different behavioural contexts

description: Laterality, the division of brain functions into separate hemispheres, is widespread across animal taxa. Lateralized individuals exhibit cognitive advantages yet substantial variation in laterality exists, particularly between the sexes. Why variation is maintained is unknown as few studies consider differences in lateralized behaviours between the sexes, and their underlying selection pressures, across different contexts. We investigated if <i>Poecilia reticulata</i> exhibited sex differences in the direction, strength and consistency of lateralization. We assessed the turning preferences of individuals detouring around a barrier to view visual stimuli representative of different behavioural contexts: an artificial object of familiar colour, an opposite sex conspecific and a no stimulus control. While no sex differences were evident in the direction or strength of laterality, consistency in the strength of laterality varied between the sexes. Individuals of both sexes consistently detoured in one direction, but the strength of laterality exhibited by males was more predictable than females across contexts. This suggests that predictability of lateralization across ecologically relevant scenarios represents a key, but previously unexplored, source of variation between the sexes.
DOI: 10.6084/m9.figshare.12204821
title: Table S4

description: Type and distribution of chromosomal structural variation
DOI: 10.6084/m9.figshare.12204824
title: Supplementary Material for: Novel Clinical Criteria Allow Detection of Short Stature Homeobox-Containing Gene Haploinsufficiency Caused by Either Gene or Enhancer Region Defects

description: <b><i>Introduction:</i></b> Short stature homeobox-containing gene (<i>SHOX</i>) haploinsufficiency is associated with short stature, Madelung deformity and mesomelia. Current clinical screening tools are based on patients with intragenic variants or deletions. However, recent discoveries showed that deletions of the enhancer elements are quite common. The majority of these patients show less body disproportion and respond better to recombinant human growth hormone treatment. We redefined clinical criteria for genetic analysis to facilitate detection of the full spectrum of <i>SHOX</i> haploinsufficiency. <b><i>Methods:</i></b> We analyzed 51 children with <i>SHOX</i> variants or deletions and 25 children with a deletion in its enhancer region. Data were compared to 277 children referred for suspicion of growth failure without endocrine or genetic pathology. <b><i>Results:</i></b> Only half of the patients with an enhancer region deletion fulfilled any of the current screening criteria. We propose new clinical criteria based on sitting height to height ratio &gt;1 SDS or arm span ≥3 cm below height, with a sensitivity of 99%. When these criteria are combined with obligatory short stature, the sensitivity to detect <i>SHOX</i> haploinsufficiency is 68.1%, the specificity 80.6%, and the number needed to screen 21 patients. <b><i>Conclusion:</i></b> Novel clinical criteria for screening for <i>SHOX</i> haploinsufficiency allow the detection of patients within the full genetic spectrum, that is, intragenic variants and enhancer region deletions.