cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.25582/data.2020-08.2030220/2063632
title: Data for EMSL Project 51127 from August 2020
DOI: 10.25582/data.2020-08.2029646/2063633
title: Data for EMSL Project 51127 from August 2020
DOI: 10.25582/data.2020-08.2029957/2063634
title: Data for EMSL Project 51127 from August 2020
DOI: 10.25582/data.2020-08.2029690/2063635
title: Data for EMSL Project 51127 from August 2020
DOI: 10.25582/data.2020-08.2030484/2063636
title: Data for EMSL Project 51127 from August 2020
DOI: 10.25582/data.2020-08.2032353/2063637
title: Data for EMSL Project 51127 from August 2020
DOI: 10.25582/data.2020-08.2030269/2063638
title: Data for EMSL Project 51127 from August 2020
DOI: 10.25582/data.2020-08.2032717/2063639
title: Data for EMSL Project 51127 from August 2020
DOI: 10.25582/data.2020-08.2029644/2063640
title: Data for EMSL Project 51127 from August 2020
DOI: 10.25582/data.2020-08.2031087/2063641
title: Data for EMSL Project 51127 from August 2020
DOI: 10.25582/data.2020-08.2033924/2063642
title: Data for EMSL Project 51127 from August 2020
DOI: 10.25582/data.2020-08.2030105/2063643
title: Data for EMSL Project 51127 from August 2020
DOI: 10.25582/data.2020-08.2031314/2063644
title: Data for EMSL Project 51127 from August 2020
DOI: 10.25582/data.2020-08.2032713/2063645
title: Data for EMSL Project 51127 from August 2020
DOI: 10.25582/data.2020-08.2031012/2063646
title: Data for EMSL Project 51127 from August 2020
DOI: 10.25582/data.2020-08.2029959/2063647
title: Data for EMSL Project 51127 from August 2020
DOI: 10.25582/data.2020-08.2036630/2063648
title: Data for EMSL Project 51127 from August 2020
DOI: 10.25582/data.2020-08.2037274/2063649
title: Data for EMSL Project 51127 from August 2020
DOI: 10.25582/data.2020-08.2032206/2063650
title: Data for EMSL Project 51127 from August 2020
DOI: 10.25582/data.2020-08.2033415/2063651
title: Data for EMSL Project 51127 from August 2020
DOI: 10.25582/data.2020-08.2032936/2063652
title: Data for EMSL Project 51127 from August 2020
DOI: 10.25582/data.2020-08.2033450/2063653
title: Data for EMSL Project 51127 from August 2020
DOI: 10.25582/data.2020-08.2036818/2063654
title: Data for EMSL Project 51127 from August 2020
DOI: 10.25582/data.2020-08.2030379/2063655
title: Data for EMSL Project 51127 from August 2020
DOI: 10.25582/data.2020-08.2030186/2063656
title: Data for EMSL Project 51127 from August 2020
DOI: 10.25582/data.2020-08.2032054/2063657
title: Data for EMSL Project 51127 from August 2020
DOI: 10.25582/data.2020-08.2030168/2063658
title: Data for EMSL Project 51127 from August 2020
DOI: 10.25582/data.2020-08.2030337/2063659
title: Data for EMSL Project 51127 from August 2020
DOI: 10.25582/data.2020-08.2030449/2063660
title: Data for EMSL Project 51127 from August 2020
DOI: 10.25582/data.2020-08.2036669/2063661
title: Data for EMSL Project 51127 from August 2020
DOI: 10.25582/data.2020-08.2034713/2063662
title: Data for EMSL Project 51127 from August 2020
DOI: 10.25582/data.2020-08.2036666/2063663
title: Data for EMSL Project 51127 from August 2020
DOI: 10.25582/data.2020-08.2037176/2063664
title: Data for EMSL Project 51127 from August 2020
DOI: 10.25582/data.2020-08.2029938/2063665
title: Data for EMSL Project 51127 from August 2020
DOI: 10.25582/data.2020-08.2030405/2063666
title: Data for EMSL Project 51127 from August 2020
DOI: 10.6084/m9.figshare.22655417
title: Additional file 7 of Identification of genetic variants that impact gene co-expression relationships using large-scale single-cell data

description: Additional file 7: Table S10. The significant co-eQTLs for the major cell types without the filtering strategy
DOI: 10.6084/m9.figshare.22655417.v1
title: Additional file 7 of Identification of genetic variants that impact gene co-expression relationships using large-scale single-cell data

description: Additional file 7: Table S10. The significant co-eQTLs for the major cell types without the filtering strategy
DOI: 10.6084/m9.figshare.22655423
title: Additional file 9 of Identification of genetic variants that impact gene co-expression relationships using large-scale single-cell data

description: Additional file 9: Table S14. GO enrichment for co-eGenes associated with the same eQTL, for all eQTLs with at least 5 co-eGenes
DOI: 10.6084/m9.figshare.22655408.v1
title: Additional file 5 of Identification of genetic variants that impact gene co-expression relationships using large-scale single-cell data

description: Additional file 5: Table S6. The significant co-eQTLs for the major cell types with the filtering strategy
DOI: 10.6084/m9.figshare.14266771.v1
title: Additional file 5 of Revealing taxon-specific heavy metal-resistance mechanisms in denitrifying phosphorus removal sludge using genome-centric metaproteomics

description: Additional file 4: Supplementary dataset. The core functioning microbes and their relationships with differentially expressed functions (protein ontologies).
DOI: 10.6084/m9.figshare.22655432
title: Additional file 12 of Identification of genetic variants that impact gene co-expression relationships using large-scale single-cell data

description: Additional file 12: Table S17. Enrichment of co-eGenes for GWAS results
DOI: 10.6084/m9.figshare.22655438
title: Additional file 14 of Identification of genetic variants that impact gene co-expression relationships using large-scale single-cell data

description: Additional file 14: Table S19. Colocalization results for co-eQTL signal with GWAS signal
DOI: 10.6084/m9.figshare.21087257
title: Additional file 7 of Intrinsic immune evasion patterns predict temozolomide sensitivity and immunotherapy response in lower-grade gliomas

description: Additional file 7. R codes.
DOI: 10.6084/m9.figshare.21087257.v1
title: Additional file 7 of Intrinsic immune evasion patterns predict temozolomide sensitivity and immunotherapy response in lower-grade gliomas

description: Additional file 7. R codes.
DOI: 10.6084/m9.figshare.21087254.v1
title: Additional file 6 of Intrinsic immune evasion patterns predict temozolomide sensitivity and immunotherapy response in lower-grade gliomas

description: Additional file 6: Supplementary Table 1. The list of immune-intrinsic evasion genes.
DOI: 10.6084/m9.figshare.20038645
title: Protection effect of sanguinarine on whole-body exposure of X radiation in BALB/c mice

description: To investigate the effects of sanguinarine (SAN) on acute radiation induced injury in mice, 45 mice were randomly divided into control, 10 Gy and SAN+10 Gy groups. Mice in the 10 Gy and SAN+10 Gy groups were exposed to single X-ray radiation with an accumulated dose of 10 Gy. Mice in the SAN+10 Gy group were administered intraperitoneally with 2.5 mg/kg body weight of SAN before radiation. Five days after radiation exposure, 5 mice from each group were sacrificed and samples of the small intestine, lung, spleen and liver were fixed for histopathological examinations. Compared with the 10 Gy group, radiation sickness was obviously delayed or attenuated in the SAN+10 Gy group. Survival analysis showed a significant difference between 2 radiation groups (P&lt;0.05) and mean survival time was 3 days longer in the SAN+10 Gy group than in the 10 Gy group (7.21±0.19 vs. 4.20±0.13, P&lt;0.001). Radiation-induced organ damage, based on histopathological examinations, was decreased by SAN pretreatment. Chiu’s pathology grading scores, which is an index of intestinal damage, was significantly lower in the SAN+10 Gy group than in the 10 Gy group (2.77±0.48 vs. 4.37±0.31, P&lt;0.01). A similar result was obtained in the pathological score of lung (1.67±0.21 vs. 2.33±0.38, P&lt;0.01). Our preliminary findings demonstrated that SAN protects animals against radiation-induced sickness and acute damage to organs and following animal death.
DOI: 10.6084/m9.figshare.20038645.v1
title: Protection effect of sanguinarine on whole-body exposure of X radiation in BALB/c mice

description: To investigate the effects of sanguinarine (SAN) on acute radiation induced injury in mice, 45 mice were randomly divided into control, 10 Gy and SAN+10 Gy groups. Mice in the 10 Gy and SAN+10 Gy groups were exposed to single X-ray radiation with an accumulated dose of 10 Gy. Mice in the SAN+10 Gy group were administered intraperitoneally with 2.5 mg/kg body weight of SAN before radiation. Five days after radiation exposure, 5 mice from each group were sacrificed and samples of the small intestine, lung, spleen and liver were fixed for histopathological examinations. Compared with the 10 Gy group, radiation sickness was obviously delayed or attenuated in the SAN+10 Gy group. Survival analysis showed a significant difference between 2 radiation groups (P&lt;0.05) and mean survival time was 3 days longer in the SAN+10 Gy group than in the 10 Gy group (7.21±0.19 vs. 4.20±0.13, P&lt;0.001). Radiation-induced organ damage, based on histopathological examinations, was decreased by SAN pretreatment. Chiu’s pathology grading scores, which is an index of intestinal damage, was significantly lower in the SAN+10 Gy group than in the 10 Gy group (2.77±0.48 vs. 4.37±0.31, P&lt;0.01). A similar result was obtained in the pathological score of lung (1.67±0.21 vs. 2.33±0.38, P&lt;0.01). Our preliminary findings demonstrated that SAN protects animals against radiation-induced sickness and acute damage to organs and following animal death.
DOI: 10.6084/m9.figshare.22655429
title: Additional file 11 of Identification of genetic variants that impact gene co-expression relationships using large-scale single-cell data

description: Additional file 11: Table S16. Annotated co-eQTL SNP with GWAS results
DOI: 10.6084/m9.figshare.22655429.v1
title: Additional file 11 of Identification of genetic variants that impact gene co-expression relationships using large-scale single-cell data

description: Additional file 11: Table S16. Annotated co-eQTL SNP with GWAS results
DOI: 10.6084/m9.figshare.9034343.v2
title: Estimating the Number of Clusters Using Cross-Validation

description: Many clustering methods, including <i>k</i>-means, require the user to specify the number of clusters as an input parameter. A variety of methods have been devised to choose the number of clusters automatically, but they often rely on strong modeling assumptions. This article proposes a data-driven approach to estimate the number of clusters based on a novel form of cross-validation. The proposed method differs from ordinary cross-validation, because clustering is fundamentally an unsupervised learning problem. Simulation and real data analysis results show that the proposed method outperforms existing methods, especially in high-dimensional settings with heterogeneous or heavy-tailed noise. In a yeast cell cycle dataset, the proposed method finds a parsimonious clustering with interpretable gene groupings. Supplementary materials for this article are available online.
DOI: 10.6084/m9.figshare.22655438.v1
title: Additional file 14 of Identification of genetic variants that impact gene co-expression relationships using large-scale single-cell data

description: Additional file 14: Table S19. Colocalization results for co-eQTL signal with GWAS signal
DOI: 10.23708/vpsrpk
title: Portion sizes in women of childbearing age and young children in Ouagadougou (Burkina Faso) using a food photography atlas and salted replicas

description: This study was aimed to compare the accuracy and precision of portion estimation with a food atlas and with salted replicas relative to weighed records (the reference). The food portion photography atlas had been developed prior to this data collection with age-appropriate portion sizes for 11 foods frequently consumed by children (sizes for 6-11-month- and for 12-23-month-old children) and women of childbearing age in Ouagadougou, the capital of Burkina Faso. Our data were collected through a survey in 2021 on a sample of 67 women with their children, 35 aged 12-23 months and 33 aged 6-11 months. The provided dataset contains estimates of portion sizes of food consumed the previous day by the participants using two different estimation tools. Data records were anonymized by removing direct and indirect identifiers.The analysis of the data collected resulted in the published article "Estimation of food portion sizes in women of childbearing age and young children in Ouagadougou (Burkina Faso) using a food photography atlas and salted replicas: comparison with weighed records". The detailed protocol of the study was approved by an ethics committee in Burkina Faso, the Ethics Committee of the Research Institute in Health Science (N° 29-2019/CEIRES). After explaining the study purpose and implementation to the participants, and giving them an information note, we asked them to sign an informed consent form.
DOI: 10.5281/zenodo.10625020
title: Diffraction minima resolve point scatterers at tiny fractions (1/80) of the wavelength - Datasets

description: This dataset is supplement to our publication about super-resolving multiple point scatterers via diffraction-minima.

The dataset contains three subsets of data: linescan data, static MINFLUX data and dynamic MINFLUX data. Each of the subsets has a directory with the raw data and additionally pre-parsed and filtered versions of the data. Please consult the API documentation of our analysis routines in order to handle the data yourself.
DOI: 10.5281/zenodo.10625021
title: Diffraction minima resolve point scatterers at tiny fractions (1/80) of the wavelength - Datasets

description: This dataset is supplement to our publication about super-resolving multiple point scatterers via diffraction-minima.

The dataset contains three subsets of data: linescan data, static MINFLUX data and dynamic MINFLUX data. Each of the subsets has a directory with the raw data and additionally pre-parsed and filtered versions of the data. Please consult the API documentation of our analysis routines in order to handle the data yourself.
DOI: 10.6084/m9.figshare.7985927.v1
title: MOESM4 of PITX2 enhances progression of lung adenocarcinoma by transcriptionally regulating WNT3A and activating Wnt/Î˛-catenin signaling pathway

description: Additional file 4: Table S4. Clinical data of 60 LUAD patients.
DOI: 10.6084/m9.figshare.21087254
title: Additional file 6 of Intrinsic immune evasion patterns predict temozolomide sensitivity and immunotherapy response in lower-grade gliomas

description: Additional file 6: Supplementary Table 1. The list of immune-intrinsic evasion genes.
DOI: 10.6084/m9.figshare.22655354.v1
title: Additional file 5 of FACI is a novel clathrin adaptor protein 2-binding protein that facilitates low-density lipoprotein endocytosis

description: Additional file 5: Figure S1. Generation of stable AML12 cells. AML12 cell lines stably expressing V5-FACI (AML12-V5-FACI) were generated and verified by immunofluorescence. A mock AML12 stable cell line (AML12-CTR) was generated and used as a control. Scale bar, 10 µm. Fig. S2. FACI localizes to CCPs in Caco-2 cells. TIRFM images. Caco-2 cells expressing mEmerald-FACI were transfected with mCherry-CLC plasmids. Scale bar, 5 μm. Fig. S3. Deletion of DxxxLI and YxxL motifs of FACI does not affect its localization to PM and ERC. (A) Confocal images of AML12 cells expressing mCherry-Rab11a and mEmerald-FACI mutants (FACI-ΔYxxL, FACI-ΔDxxxLI, and FACI-ΔYxxL-DxxxLI). Scale bar, 20 µm. (B) Confocal images of AML12 cells expressing mCherry-Rab11a and mEmerald-FACI mutants (FACI-Δ2-68 and FACI-Δ2-82). Scale bar, 10 µm. Fig. S4. AML12 cells expressing mCherry-AP2M1 were transfected with mEmerald-FACI or mEmerald-FACI-ΔDxxxLI plasmid. Cells were lysed and immunoprecipitated with anti-mCherry. Immunoprecipitates were analyzed by SDS-PAGE and probed with the indicated antibodies. Fig. S5. (A,B) AML12-mRuby2-FACI stable cells were incubated with Pitstop-2 (A), NDZ (B, upper panel) or CytD (B, lower panel) for the indicated time periods. Cells were kept on the TOKAI HIT stage-top incubator with 5% CO2 at 37°C of the microscope and imaged by SDCM at the indicated time points. Scale bar, 10 µm. (C) Quantification of the intracellular mRuby2-FACI fluorescence intensity relative to the intensity of the whole cell before (Ctrl 0 min) and after drug treatment (NDZ 90 min, CytD 90 min or Pitstop-2 75 min). n = 25-35. Statistical significance was evaluated by one-way ANOVA with Tukey's post hoc tests. Fig. S6. A C57BL/6J mice (8 weeks old, n=6) and FACI-/- mice (8 weeks old, n=7) were fed with a high-cholesterol diet for 4 weeks. Body weights, liver weights, liver cholesterol and liver triglyceride contents of mice were measured. B C57BL/6J mice (6 weeks old) were injected with AAV-FACI (n = 8) or AAV-GFP (n = 7). After two-week transduction, mice were fed with a high-cholesterol diet for another 4 weeks. AAV-mediated exogenous FACI expression in livers was analyzed by RT-qPCR. C Body weights, liver weights, liver cholesterol and liver triglyceride contents of mice in B were measured.
DOI: 10.6084/m9.figshare.20038713.v1
title: A suppository-base-matrix tablet for time-dependent colon-specific delivery system

description: Our research has focused on the main design features and release performances of time-dependent colon-specific (TDCS) delivery tablets, which relies on the relative constancy that is observed in the small intestinal transit time of dosage forms. But inflammatory bowel disease（IBD）can affect the transit time, and usually results in watery stool. Compared to the TDCS and wax-matrix TDCS tablet, a promising time-dependent colon-specific delivery system was investigated. In our study, a suppository-base-matrix coated tablet was evaluated. Water soluble suppository-base helps the expansion of tablet, facilitates uniform film dissolution and achives high osmotic pressure. Combining the expansion of carboxymethyl starch sodium (CMS-Na) and the moisture absorption of NaCl, the coated TDCS tablet obtained a burst and targeted drug delivery system. A very good correlation between in vitro drug release and in vivo outcome was observed. This TDCS coated tablet provides a promising strategy to control drug release to the desired lower gastrointestinal region.
DOI: 10.6084/m9.figshare.22655405
title: Additional file 4 of Identification of genetic variants that impact gene co-expression relationships using large-scale single-cell data

description: Additional file 4: Table S3. eQTLs for major cell types.
DOI: 10.6084/m9.figshare.22655414.v1
title: Additional file 6 of Identification of genetic variants that impact gene co-expression relationships using large-scale single-cell data

description: Additional file 6: Table S9. BIOS replication for filtered co-eQTLs for major cell types.
DOI: 10.7270/q2js9rcz
title: BindingDB Entry 50038836: Novel non-active site inhibitor of Cryptosporidium hominis TS-DHFR identified by a virtual screen.

description: Small molecule binding data for protein Dihydrofolate reductase, Dihydrofolate reductase (DHFR), and Thymidylate synthase, Uniprot P00374, P04818, and Q07422
DOI: 10.7270/q2n58n6t
title: BindingDB Entry 50037936: Acridone derivatives: design, synthesis, and inhibition of breast cancer resistance protein ABCG2.

description: Small molecule binding data for protein ATP-binding cassette sub-family G member 2, Uniprot Q9UNQ0
DOI: 10.7270/q2pg1sb1
title: BindingDB Entry 50036166: Conformationally restrained analogs of sympathomimetic catecholamines. Synthesis, conformational analysis, and adrenergic activity of isochroman derivatives.

description: Small molecule binding data for protein ADRB2, Adrenergic receptor beta, Beta-1 adrenergic receptor, and Beta-2 adrenergic receptor, Uniprot P18090, Q28044, and Q8K4Z4
DOI: 10.7270/q2pk0h2s
title: BindingDB Entry 50038835: Design and synthesis of 4-aryl-4-oxobutanoic acid amides as calpain inhibitors.

description: Small molecule binding data for protein Calpain1/2, Uniprot P07384
DOI: 10.7270/q2qc04h9
title: BindingDB Entry 50039685: Discovery of a series of 2-(1H-pyrazol-1-yl)pyridines as ALK5 inhibitors with potential utility in the prevention of dermal scarring.

description: Small molecule binding data for protein ALK5, Activin receptor type-1B, Serine/threonine-protein kinase receptor R3, and TGF-beta receptor type I, Uniprot P36896, P36897, P37023, and Q64729
DOI: 10.7270/q2rv0ph2
title: BindingDB Entry 50037935: Parallel synthesis and SAR study of novel oxa-steroids as potent and selective progesterone receptor antagonists.

description: Small molecule binding data for protein Glucocorticoid receptor and Progesterone receptor, Uniprot P04150 and P06401
DOI: 10.7270/q2t72j2r
title: BindingDB Entry 50036165: Deoxygenated inositol 1,4,5-trisphosphate analogues and their interaction with metabolic enzymes. (1R,2R,4R)-cyclohexane-1,2,4-tris(methylenesulfonate): a potent selective 5-phosphatase inhibitor.

description: Small molecule binding data for protein Type I inositol-1,4,5-trisphosphate 5-phosphatase, Uniprot Q14642
DOI: 10.7270/q2t72jcs
title: BindingDB Entry 50038834: Discovery and development of heat shock protein 90 inhibitors.

description: Small molecule binding data for protein Epidermal growth factor receptor and ErbB2 (HER1 and HER2), HSP90 and hnRNPA2/B1, and Heat Shock Protein 90 (Hsp90), Uniprot P02829, P04626, and P08238
DOI: 10.7270/q2v69k8g
title: BindingDB Entry 50037006: Factors influencing agonist potency and selectivity for the opioid delta receptor are revealed in structure-activity relationship studies of the 4-[(N-substituted-4-piperidinyl)arylamino]-N,N-diethylbenzamides.

description: Small molecule binding data for protein Nociceptin/mu opioid receptor, Opioid receptor, and Opioid receptors; mu & delta, Uniprot P33533, P33535, and P34975
DOI: 10.7270/q2wm1f6b
title: BindingDB Entry 50037934: Novel 2-aminobenzothiazoles as selective neuronal nitric oxide synthase inhibitors.

description: Small molecule binding data for protein Nitric oxide synthase, brain, Nitric oxide synthase, endothelial, Nitric oxide synthase, inducible, Nitric-oxide synthase (endothelial and brain), and Nitric-oxide synthase, brain, Uniprot P29475, P29476, P35228, Q06518, and Q62600
DOI: 10.7270/q2z038s2
title: BindingDB Entry 50036164: Inhibition of herpes simplex virus type 1 ribonucleotide reductase by substituted tetrapeptide derivatives.

description: Small molecule binding data for protein Ribonucleoside-diphosphate reductase RR1, Uniprot P23921
DOI: 10.7270/q2z03922
title: BindingDB Entry 50038833: Indanesulfonamides as carbonic anhydrase inhibitors and anticonvulsant agents: structure-activity relationship and pharmacological evaluation.

description: Small molecule binding data for protein Carbonic Anhydrase XIV, Carbonic anhydrase 12, and Carbonic anhydrase 7, Uniprot O43570, P43166, and Q9ULX7
DOI: 10.7270/q2zw1mzn
title: BindingDB Entry 50039683: Discovery of cariprazine (RGH-188): a novel antipsychotic acting on dopamine D3/D2 receptors.

description: Small molecule binding data for protein DOPAMINE, Dopamine D1 and D2 receptor, Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor, Dopamine D5 receptor, Dopamine receptor, and Dopamine receptor D2L/neurotensin receptor NTS1, Uniprot P14416, P18901, P19020, P21728, P21918, P35462, and P61169
DOI: 10.7270/q20c4wk9
title: BindingDB Entry 50037941: Structural factors contributing to the Abl/Lyn dual inhibitory activity of 3-substituted benzamide derivatives.

description: Small molecule binding data for protein SRC and Tyrosine-protein kinase ABL1, Uniprot P00519 and P07948
DOI: 10.7270/q21r6r4p
title: BindingDB Entry 50036172: Synthesis of structural analogs of leukotriene B4 and their receptor binding activity.

description: Small molecule binding data for protein LTB4R, Uniprot Q15722
DOI: 10.7270/q22n539z
title: BindingDB Entry 50039690: Synthesis and Evaluation of the Metabolites of AMG 221, a Clinical Candidate for the Treatment of Type 2 Diabetes.

description: Small molecule binding data for protein 11-beta-hydroxysteroid dehydrogenase 1, Uniprot P28845 and P50172