DOI: 10.5061/dryad.6hdr7srbs
title: Data from: Inter-species differences in wound-healing rate: A comparative study involving primates and rodents

description: Injuries, which affect survival and biological functioning, are common in
 the animal kingdom. This study systematically investigated whether the
 slow wound healing observed in humans is a unique characteristic within
 the primate order. First, we found no significant difference in
 wound-healing rates between baboons under experimental conditions and
 those in their natural environment (0.613 mm/day). Second, comparisons
 among four non-human primates (velvet monkeys, Sykes' monkeys,
 baboons, and chimpanzees) revealed no significant differences in
 wound-healing rates. Furthermore, these rates showed no significant
 differences compared to those observed in rodents, suggesting a potential
 commonality in wound-healing rates across diverse animal species. In
 contrast, human wound-healing rates were found to be markedly slower (0.25
 mm/day), approximately three times slower than those observed in non-human
 primates. This finding indicates that the slow wound healing observed in
 humans is not a common characteristic among primate order, and highlights
 the possibility of evolutionary adaptations in humans. Understanding these
 interspecies differences in wound-healing rates may provide valuable
 insights into the evolutionary implications of wound healing. This study
 also underscores the need for further research into the biological
 processes underlying wound healing in various species.
description: <strong>Subjects:</strong> 
 
 <em><strong>Cercopithecines</strong></em>: Three non-human primates in captivity were used: anubis baboons (n = 6), Sykes' monkeys (n = 5), and vervet monkeys (n = 6). All animals were anaesthetized, and full-thickness skin wounds (40 mm diameter) were created. The wounds were treated with gentamicin and covered for 1 day. Wound healing was monitored by photographing the wounds every 2–3 days. For wild baboons, data from Taniguchi and Matsumoto-Oda [16] were used for analysis. <strong>Chimpanzees</strong>: Five captive adult chimpanzees (one female, four males) were used. Natural wounds were photographed at intervals of 2–7 days, and wound dimensions were measured using a ruler. <strong>Humans</strong>: A total of 24 patients (14 females, 10 males, aged 25–99) were included. Wounds were photographed following skin tumor removal. <strong>Rodents</strong>: Mice (BALB/c and Jcl:SD) and rats were anaesthetized, and their backs were shaved before creating wounds. Wounds were monitored at 1–2 day intervals. <strong>Healing Rate</strong>: Wound healing distances were measured at multiple time points and analyzed using linear regression to determine healing rates. Measurements were taken using ImageJ software. <strong>Statistical Analysis</strong>: Linear mixed models were used to analyze the data, accounting for random effects in repeated measurements. For humans, age-related effects on healing were also modeled. All analyses were performed using R software version 4.1.2.
description: # Inter-species differences in wound-healing rate: a comparative study
 involving primates and rodents
 [https://doi.org/10.5061/dryad.6hdr7srbs](https://doi.org/10.5061/dryad.6hdr7srbs) ## Description of the data and file structure **SUPPLEMENTAL INFORMATION** Supplemental Information includes six tables, and one figure, and original data have been uploaded to the digital repository after acceptance. **Tables** **S1** Comparison of rate of healing distance between natural and experimental wounds for baboons. **S2** Comparison of rate of healing distance among non-human primates. **S3** Comparison of rate of healing distance between humans and non-human primates. **S4** Testing the influence of sex on rate of healing distance for humans. **S5** Testing the influence of age on rate of healing distance for humans. **S6** Testing the influence of body location on rate of healing distance for humans. **FigureS1**: Healing rate in hairy and hairless rodents. Data: The data file (【All_data】ms-wound_healing_by_AMO) contains records of time elapsed since maximum wound size and wound healing rates for four non-human primate species (anubis baboons, Sykes' monkeys, vervet monkeys, and chimpanzees), humans, and rodents (mice and rats). The Column "Wound-healing distance (L)" is the reference size of the wound (the maximum, thus at time 0) minus the measured wound distance.