cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.11317085.v1
title: Supplementary Material for: Rapamycin Treatment Reduces Acute Myocarditis Induced by <b><i>Trypanosoma cruzi</i></b> Infection

description: Chagas disease affects millions of people mainly in Latin America and is a protozoan illness caused by the parasite <i>Trypanosoma cruzi</i>. Chagasic cardiomyopathy is the leading cause of mortality of infected patients, due to compromised electrical and mechanical cardiac function induced by tissue remodeling, especially fibrosis, and lymphocytic infiltration. Some cellular biochemical pathways can be protective to the heart, and we tested if the in vivo activation of the autophagic machinery by rapamycin could reduce parasite-induced myocarditis. Regarding the expression of LC3, an autophagy marker, we observed its upregulation in the cardiac tissue of infected untreated mice. However, after rapamycin treatment, an autophagy inducer, infected mice showed reduced electrical cardiac dysfunctions, myocarditis, cardiac damage, and reduced production of pro-inflammatory cytokines by the heart. On the other hand, the parasite’s life cycle was not affected, and we observed no modulations in cardiac tissue or blood parasitemia. Our data indicate that, at least partially, autophagy induction controls inflammation in the heart¸ illustrating the complexity of the pathways that concur to the development of the infection.
DOI: 10.6084/m9.figshare.28875686.v1
title: MEMAHAMI ITQON, PENGERTIAN, DAN IMPLEMENTASINYA DALAM PELAYANAN KESEHATAN.pdf

description: Penelitian ini bertujuan untuk mengkaji pemahaman dan implementasi nilai-nilai Itqon dalam pelayanan kesehatan, serta dampaknya terhadap kualitas pelayanan medis dan kepuasan pasien. Itqon adalah konsep Islam yang mengedepankan kesempurnaan, ketelitian, dan integritas dalam setiap aspek kehidupan, termasuk dalam praktik medis. Melalui pendekatan kualitatif berbasis studi literatur, penelitian ini menggabungkan sumber-sumber primer Islam klasik,seperti Al-Qur'an, Hadis, serta karya-karya ulama, dengan telaah literatur modern di bidang kesehatan, serta observasi non-formal terhadap praktik klinis di rumah sakit. Hasil penelitian menunjukkan bahwa implementasi nilai Itqon dalam pelayanan kesehatan dapat meningkatkan kualitas perawatan, memperkuat hubungan profesional antara tenaga medis dan pasien, serta mendukung prinsip-prinsip global mutu pelayanan seperti keselamatan pasien, keunggulan klinis, dan perawatan manusiawi. Penelitian ini juga menemukan bahwa prinsip-prinsip Itqon berkontribusi terhadap pembentukan profesionalisme tenaga medis, baik dalam keahlian teknis maupun dalam aspek spiritual dan etika. Berdasarkan temuan tersebut, penelitian ini merekomendasikan agar prinsip Itqon diintegrasikan dalam pendidikan dan pelatihan tenaga medis, serta diterapkan dalam kebijakan rumah sakit untuk meningkatkan kualitas pelayanan.Implementasi nilai Itqon secara konsisten dapat menciptakan lingkungan medis yang lebih humanis dan berkualitas.
DOI: 10.6084/m9.figshare.10315784.v4
title: Earth Analytics Bootcamp | Final Project Dataset | Precipitation Data for Boulder, CO and San Francisco, CA for 1948 to 2018

description: This dataset contains:<br>1. boulder-monthly-precip-mm-1948-2018.csv: total monthly precipitation (millimeters) for each month and year for Boulder, CO between 1948 and 2018. The data are organized with a row for each for each year (in order from 1948 to 2018) and one column for month (in order from January to December). This file does not contain headers.<br> Original data from U.S. National Oceanic and Atmospheric Administration (NOAA): https://www.esrl.noaa.gov/psd/boulder/Boulder.mm.precip.html<br><br>2. san-franscisco-monthly-precip-mm-1948-2018.csv: total monthly precipitation (millimeters) for each month and year for San Francisco, CA between 1948 and 2018. <br>The data are organized with a row for each for each year (in order from 1948 to 2018) and one column for month (in order from January to December). This file does not contain headers. <br>Original data from the National Weather Service: https://w2.weather.gov/climate/xmacis.php?wfo=mtr
DOI: 10.6084/m9.figshare.11462469.v3
title: Genotype dataset for sorghum association panel (SAP)

description: Unimputed genotype datasets are in the vcf format. User can redo the quality control for their own purposes. The imputed genotype dataset was in the hapmap format including which is ready for conducting GWAS. The beagle was used for the imputation.
DOI: 10.6084/m9.figshare.7370642
title: Supplementary Material for: miRNA-1290 Promotes Aggressiveness in Pancreatic Ductal Adenocarcinoma by Targeting IKK1

description: <b><i>Background/Aims:</i></b> MicroRNAs (miRNAs) are a group of non-coding RNAs that play diverse roles in pancreatic carcinogenesis. In pancreatic ductal adenocarcinoma (PDAC), NF-kB is constitutively activated in most patients and is linked to a mutation in KRAS via IkB kinase complex 1 (IKK1, also known as IKKa). We investigated the link between PDAC aggressiveness and miR-1290. <b><i>Methods:</i></b> We used miRCURY<sup>TM</sup> LNA Array and <i>in situ</i> hybridization to investigate candidate miRNAs and validated the findings with PCR. The malignant behavior of cell lines was assessed with Cell Counting Kit-8, colony formation, and Transwell assays. A dual-luciferase reporter assay was used to evaluate the interaction between miR-1290 and IKK1. Protein expression was observed by western blotting. <b><i>Results:</i></b> In this study, 36 miRNAs were dysregulated in high-grade pancreatic intraepithelial neoplasia (PanIN) and PDAC tissues compared with low-grade PanIN tissues. The area under the curve values of miR-1290 and miR-31-5p were 0.829 and 0.848, respectively (95% confidence interval, 0.722–0.936 and 0.749–0.948, both P &lt; 0.001). There was a significant correlation between miR-1290 and histological differentiation (P = 0.029), pT stage (P = 0.006), and lymph node metastasis (P = 0.001). In addition, the <i>in vitro</i> work showed that miR-1290 promoted PDAC cell proliferation, invasion, and migration. Western blotting and the dual-luciferase reporter assay showed that miR-1290 promoted cancer aggressiveness by directly targeting IKK1. The synergist effect of miR-1290 on the proliferation and metastasis of PDAC cells was attenuated and enhanced by IKK1 overexpression and knockdown, respectively. Consistent with the <i>in vitro</i> results, a subcutaneous tumor mouse model showed that miR-1290 functioned as a potent promoter of PDAC <i>in vivo</i>. <b><i>Conclusion:</i></b> MiR-1290 may act as an oncogene by directly targeting the 3’-untranslated region of IKK1, and the miR-1290/IKK1 pathway may prove to be a novel diagnostic and therapeutic target for PDAC.
DOI: 10.17632/44n4m42rvw
title: Evaluation of stretch reflex synergies in the upper limb using principal component analysis (PCA)

description: The data was obtained from the right arm of 16 (8:8, female:male) right handed participants. Surface electromyography (EMG) signals were recorded from seven arm muscles: (1) m. brachioradialis, (2) m. biceps brachii, (3) m. triceps brachii caput laterale, (4) m. triceps brachii caput longum, (5) m. deltoideus pars anterior (6) m. deltoideus pars posterior, and (7) m. pectoralis major.
DOI: 10.17632/9k9cgb8mwy
title: Remission of human type 2 diabetes requires decrease in liver and pancreas fat content but is dependent upon capacity for beta cell recovery. Taylor et al. (2018)

description: This dataset contains data used to present results in the following paper: Remission of human type 2 diabetes requires decrease in liver and pancreas fat content but is dependent upon capacity for beta cell recovery Taylor et al. (2018), Cell Metabolism 28, 1-10. https://doi.org/10.1016/j.cmet.2018.07.003
DOI: 10.6084/m9.figshare.14370896.v1
title: Stimulation of ammonia oxidizer and denitrifier abundances by nitrogen loading: Poor predictability for increased soil N2O emission

description: Yong Zhang, Feng Zhang, Diego Abalos, Yiqi Luo, Dafeng Hui, Bruce A Hungate, Pablo García-Palacios, Yakov Kuzyakov, Jørgen Eivind Olesen, Uffe Jørgensen, Ji Chen. Stimulation of ammonia oxidizer and denitrifier abundances by nitrogen loading: Poor predictability for increased soil N<sub>2</sub>O emission.<i>Global Change Biology</i>.
DOI: 10.17632/xhrjsbwg92
title: Baghdadi_Cell Stem Cell_D-17-00836_2018

description: Supplementary Movie 1: Related to Fig. 3C and D Cell trajectories of a 48h time-lapse movie of membrane-GFP positive cells isolated from resting muscle of Tg:Pax7-CT2;R26mTmG mice transfected immediately after FACS with Scramble control (top) or Mimic-708 (bottom). Images were taken every 13min. Scale bar: 50μm. Supplementary Movie 2 and 3: Related to Fig. 3E and F 2-Photon live videomicroscopy on Extensor digitorium longus muscle of Scramble-treated mice (10days post-injection). Representative zoom on cells showing no cell displacement over 12h. Images were taken every 30min. Supplementary Movie 4 and 5: Related to Fig. 3E and F 2-Photon live videomicroscopy on Extensor digitorium longus muscle of AntagomiR-treated mice (10days post injection). Representative zoom on cells showing spontaneous displacement and exit from niche following miR-708 knock-down in vivo. Images were taken every 30min. Supplementary Movie 6: Related to Fig. 3J Cell trajectory of primary satellite cells overexpressing miR-708 (Mimic) only or both miR-708 and TNS3. Overexpression of TNS3 was sufficient to rescue the inhibition of migration mitigated by mir-708. Images were taken every 10min for 20h. Supplementary Movie 7: Related to Fig. 4F-H Videomicroscopy of a Fucci-green-positive cell isolated from resting muscle and transfected 24h after FACS with Scramble control (top) or Mimic-708 (bottom). Images were taken every 13min for 25h.
DOI: 10.6084/m9.figshare.21671246.v1
title: Untitled Item

description: soil bacterial diversity and properties
DOI: 10.6084/m9.figshare.8866556.v1
title: Synthetic one dimensional regression data and fit

description: A synthetic one dimensional linear regression dataset with latent slope, intercept, and noise ("eps"). One hundred data points, fit with PyMC3. <br>True slope and intercept are included as deterministic variables.
DOI: 10.17632/4y8dvfw4jm
title: A Study on the Management Styles among MSME Owners in the City of Manila By: Leonardo F. Cada, Jr.*
DOI: 10.6084/m9.figshare.5644870.v1
title: Melipona mondury produces a geopropolis with antioxidant, antibacterial and antiproliferative activities

description: ABSTRACT Geopropolis is a special type of propolis produced by stingless bees. Several pharmacological properties have been described for different types of geopropolis, but there have been no previous studies of the geopropolis from Melipona mondury. In this study, we investigated the antioxidant, antibacterial, and antiproliferative activities of M. mondury geopropolis, and determined its chemical profile. The antioxidant activity was determined using in vitro ABTS·+, ·DPPH, and β-carotene/linoleic acid co-oxidation methods. The antibacterial activity was determined using a microdilution method with Pseudomonas aeruginosa, Staphylococcus aureus, and methicillin-resistant S. aureus. The antiproliferative effect was determined in tumor cell lines using the Alamar Blue assay. The chemical profile was obtained using UHPLC-MS and UHPLC-MS/MS. The butanolic fraction had the highest concentration of phenolic compounds and more potent antioxidant properties in all assays. This fraction also had bacteriostatic and bactericidal effects against all bacterial strains at low concentrations, especially S. aureus. The hexane fraction had the highest antiproliferative potential, with IC50 values ranging from 24.2 to 46.6 µg/mL in HL-60 (human promyelocytic leukemia cell) and K562 (human chronic myelocytic leukemia cell), respectively. Preliminary chemical analysis indicates the presence of terpenes and gallic acid in the geopropolis. Our results indicate the therapeutic potential of geopropolis from M. mondury against inflammatory, oxidative, infectious, and neoplastic diseases.
DOI: 10.6084/m9.figshare.6974012.v1
title: Supplementary Material for: Anti-Cancer Effects of Radix Angelica Sinensis (Danggui) and N-Butylidenephthalide on Gastric Cancer: Implications for REDD1 Activation and mTOR Inhibition

description: <b><i>Background/Aims:</i></b> <i>Radix Angelica Sinensis</i> (danggui in Chinese) is widely used in traditional chinese medicine (TCM). N-butylidenephthalide (BP), a bioactive compound in <i>danggui</i>, is a potential antitumor agent for various cancer types. However, its clinical effect and mechanism in the treatment of gastric cancer remain undetermined. <b><i>Methods:</i></b> The <i>in vivo</i> protective effect of <i>danggui</i> in patients with gastric cancer were validated using data from Taiwan’s National Health Insurance Research Database (NHIRD). The genes induced by BP-treatment were analyzed by whole transcriptome RNA sequencing (RNA-seq) and validated by real-time PCR, western blot and siRNA transfection. The effect of BP on AGS cell migration and invasion was evaluated in transwell assays. The antitumor effects of BP were evaluated <i>in vivo</i> in an AGS xenograft animal model. <b><i>Results:</i></b> <i>Danggui</i> users were found to have an increased survival rate when compared with <i>danggui</i> nonusers (log-rank test <i>p</i> = 0.002) . The use of <i>danggui</i> highly associated with decreased mortality (the adjusted hazard ratio (HR) of <i>danggui</i> user was 0.72 [95 % CI, 0.57-0.92] (<i>p</i> = 0.009). The <i>in vitro</i> results showed that BP inhibited gastric cancer cell proliferation, and triggered cellular apoptosis depending on the activation of mitochondrial apoptotic pathway. Using RNA-seq analysis we found that REDD1 was the highest transcript induced by BP in gastric cancer cells. BP induce an increase of REDD1 expression that inhibits mTOR signaling, thus inhibiting gastric cancer growth. We used RNA interference to demonstrate that the knock-down of REDD1 attenuated the BP-induced mTORC1 activation and growth inhibition. BP suppressed the growth of AGS xenografts tumor <i>in vivo</i>. <b><i>Conclusion:</i></b> <i>Danggui</i> can prolong the survival rate of gastric cancer patients in Taiwan. BP caused gastric cancer cell death through the activation of mitochondria-intrinsic pathway and induced the REDD1 expression leading to mTOR signal pathway inhibition in gastric cancer cells. BP inhibited the <i>in vivo</i> growth of AGS xenograft tumors. These results may provide the basis for a new therapeutic approach toward the treatment of gastric cancer progression.
DOI: 10.6084/m9.figshare.27247074.v2
title: Static back-scatter electric field data of four typical spatial conical targets.

description: <b>NOTE: </b>This dataset is part of the project IMD. We highly recommend that you first review the project details to gain a better understanding of the dataset's background.In this dataset, you can find front-view images (<i>.pdf) of four target types within each directory. </i><i> </i><i>In addition, their static electromagnetic scattering data at 9 GHz to 11 GHz (with an interval of 0.01 GHz) is also provided </i><i>(</i><i>*.csv</i><i>)</i>. In each CSV file, the static aspect angles (theta) range from 29 to 173 degrees, with an interval of 0.01 degrees. This sampling range is determined by the dynamic aspect angle dataset obtained from ballistic micro-motion target simulations, while the sampling interval is based on accuracy requirements.The relationship between this data and the final dynamic echo data is well explained in the paper found at this link. The specific simulation methods, including kinematic modeling and dynamic sequence generation codes, can be found in the GitHub repository for now. Once the final proofreading is completed, they will be added under this project. Repository link: https://github.com/NilasZ/MRM.For any questions, feel free to contact us:cherium@outlook.comjianxuan.xu@hdr.mq.edu.au
DOI: 10.6084/m9.figshare.28789880.v1
title: removed reviews

description: removed reviews
DOI: 10.6084/m9.figshare.24081438.v39
title: lunar_surface_chemistry_maps

description: The data files depict the Mg# values and the abundances of SiO2, TiO2, Al2O3, FeO, MgO and CaO observed by the KAGUYA multiband imager. The data files are in the format of .tif and can be opend by the software ArcGIS.
DOI: 10.6084/m9.figshare.26300401.v2
title: PLS2011 data USonly.sav

description: Responses from 125 men about their experience with sexual orientation change efforts (SOCE)
DOI: 10.6084/m9.figshare.c.3615806_d9.v1
title: Additional file 10: Table S6. of Single-cell analysis of long non-coding RNAs in the developing human neocortex

description: Related to Fig.Â 3. Single cell expression table. A total of 276 single cells from human neocortex development and all genes (including known and novel lncRNAs) that pass the minimum expression threshold (Methods). Expression values are in size factor normalized counts, according to DESeq. (XLS 31786 kb)
DOI: 10.6084/m9.figshare.c.3642038_d3.v1
title: Additional file 3: Dataset S1. of Slowed aging during reproductive dormancy is reflected in genome-wide transcriptome changes in Drosophila melanogaster

description: Gene list of significantly regulated probes and reciprocal comparison. Transcripts that are significantly altered more than two-fold (|log2FC| ≥ 1, q ≤ 0.05) are shown. 3wDvs1wN represent transcripts regulated upon 3 weeks of diapause compared to 1 week control flies, 3wDvs3wN represent genes regulated in diapause samples with comparison to 3 week old sibling controls, 3wNvs1wN represent genes influenced by aging in 3 week old control flies compared to 1 week old control flies. Significantly inhibited transcripts are highlighted in blue, significantly activated in orange. Links to Flybase, Wikigene, Genecard, NCBI, ENSEMBL and ExPASy databases are included. (XLSX 2131 kb)
DOI: 10.6084/m9.figshare.24645798.v1
title: Fairer AI in Ophthalmology via Implicit Fairness Learning for Mitigating Sexism and Ageism

description: We collect the largest and most diverse fundus image dataset with data from over 8,405 patients representing a wide age range (0 to 90 years). The fundus dataset contains two types of advanced ultra-widefield and regular narrow-angle fundus images, with the ultra-widefield imaging dataset containing 16,530 fundus images annotated with 38 ophthalmic diseases and 67 fundus features and the narrow-angle imaging dataset containing 4,540 fundus images annotated with 16 ophthalmic diseases and 20 fundus features. We hereby only provide the test set of our dataset, while the complete dataset can be accessed through the Google Drive link provided in the paper. (Despite our attempts to upload the full dataset, the transmission time was excessively long due to its size exceeding 100G, necessitating this alternative method.)
DOI: 10.6084/m9.figshare.7185668.v1
title: Determination of 4-Nonylphenol in Surface Waters of the Guandu River Basin by High Performance Liquid Chromatography with Ultraviolet Detection

description: 4-Nonylphenol, a degradation product of ethoxylated alkylphenols, due to its harmful effects on the environment, has been banned in European Union countries, alongside their precursors. The guide on quality of drinking water from the United States Environmental Protection Agency (US EPA) recommends a maximum concentration of 28 µg L-1 for fresh water. In Brazil, there is no clear legislation containing values of maximum concentration of 4-nonylphenol. Due to this lack of regulation, a continuous monitoring is necessary for this pollutant in environmental samples. The occurrence of 4-nonylphenol (4-NP) in the surface waters of Guandu River in the state of Rio de Janeiro, Brazil, was studied by using solid-phase extraction and reversed phase liquid chromatography separation with UV detection. The analytical method satisfies these requirements, being able to detect and quantify 4-NP in a desired concentration range. Of the 19 samples analyzed, 4-nonylphenol was detected in 12, quantified in 2, showing concentration levels of 1.73 and 2.32 µg L-1 in Santa Cruz and Paracambi, respectively. This is the main hydrographic basin in the state of Rio de Janeiro, where water is collected for treatment and later distributed to most cities in the metropolitan region, including Rio de Janeiro City, and these results are therefore alarming.
DOI: 10.6084/m9.figshare.28005842.v1
title: Supplementary Material for: Treatment of paediatric colchicine poisoning with single-pass albumin dialysis: A case report

description: Introduction: Colchicine has a narrow therapeutic index, and doses &gt;0.5 mg/kg are considered toxic with a high mortality rate. 
Case presentation: A previously healthy 15-year-old presents to the emergency department with abdominal pain and vomiting following intentional ingestion of colchicine (0.56 mg/kg) 12 hours prior. By 24 hours post-ingestion, they developed a multiorgan injury with hepatic dysfunction, coagulopathy, lactic acidemia and pancytopenia, which prompted consideration of extracorporeal therapy (ECT). Considering the characteristics of colchicine, they were treated with continuous venovenous hemodiafiltration (CVVHDF) with single-pass albumin dialysis (SPAD) for 42 hours. They were subsequently discharged from the intensive care unit 48 hours after stopping CVVHDF with normal kidney function, resolved coagulopathy, and resolving pancytopenia and hepatic dysfunction. The rationale for CVVHDF with SPAD was based on the high protein binding, variably high volume of distribution, previous reports showing a sieving coefficient of 0.2 with CVVH, and the high mortality risk. We anticipated a high potential for rebound. Thus, continuous clearance would facilitate redistribution from the extravascular to intravascular space. SPAD was used to enhance the elimination of protein-bound fractions; the principle is that adding albumin to dialysate creates a protein-binding disequilibrium where the drug from the blood side may bind to albumin on the dialysate side. Conclusion: Colchicine ingestion of &gt;0.5mg/kg is highly toxic, and in addition to supportive management, continuous kidney replacement therapy with SPAD may be considered.
DOI: 10.6084/m9.figshare.20219937.v3
title: Invertebrate abundance data from an intermittent Ozark stream in dry phase and early flowing phase.

description: Invertebrate abundance data from an intermittent Ozark stream in dry phase and early flowing phase. <br> This data file contains two tables: 1) Full list of taxa identified from a gravel rehydration study (“Buckets”) during the dry season and semi-quantitative (with D-frame kick net) during the first two months of the flow season in Shelton Creek, Christian County, Missouri. “Pool” = a reach maintaining some standing, isolated pools during the dry season; “No-Pool” = a reach with no remaining surface water during the dry season. 2) The full taxa list from the “Buckets” as described above, here separated into collection time in days following rehydration in the lab. <br>
DOI: 10.6084/m9.figshare.27122073.v1
title: <b>Initiation of Sediment Resuspension by combined Wave-Current Conditions in an Artificial Seagrass Meadow</b>

description: Data of wave and current velocity, turbulent kinetic energy, and near-bed sediment concentration associated with the manuscript "<b>Initiation of Sediment Resuspension by combined Wave-Current Conditions in an Artificial Seagrass Meadow</b>" by Chuyan Zhao and Heidi Nepf.
DOI: 10.6084/m9.figshare.19636617.v1
title: Data from: Bombardiers and assassins: mimetic interactions between unequally defended insects

description: Sugiura S, Hayashi M (2023) Bombardiers and assassins: mimetic interactions between unequally defended insects. Peerj (https://doi.org/10.7717/peerj.15380)
DOI: 10.6084/m9.figshare.7523420.v2
title: Stress/deformation/width change of worm under strong confinement

description: Stress/deformation/width change of worm under strong confinement