cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.14714906.v1
title: Epigenetic reader BRD4 supports mycobacterial pathogenesis by co-modulating host lipophagy and angiogenesis

description: <i>Mycobacterium tuberculosis</i> (Mtb)-driven lipid accumulation is intricately associated with the progression of tuberculosis (TB) disease. Although several studies elucidating the mechanisms for lipid droplet (LD) biosynthesis exist, we provide evidence for the significance of their regulated turnover via macroautophagy/autophagy during Mtb infection. We demonstrate that Mtb utilizes EGFR (epidermal growth factor receptor) signaling to induce the expression of the histone acetylation reader, BRD4 (bromodomain containing 4). The EGFR-BRD4 axis suppresses lipid-specific autophagy, and hence favors cellular lipid accumulation. Specifically, we found that pharmacological inhibition or knockdown of <i>Egfr</i> or <i>Brd4</i> enhances autophagic flux and concomitantly decreases cellular LDs that is otherwise maintained at a significant level in chloroquine-treated or <i>Atg5</i> knocked down autophagy-compromised host cells. In line with the enhanced lipophagy, we found that loss of EGFR or BRD4 function restricts mycobacterial burden that is rescued by external replenishment with oleic acid. We also report that the EGFR-BRD4 axis exerts additional effects by modulating pro-angiogenic gene expression and consequently aberrant angiogenesis during mycobacterial infection. This is important in the context of systemic Mtb dissemination as well as for the efficient delivery of anti-mycobacterial therapeutics to the Mtb-rich core of TB granuloma. Finally, utilizing an <i>in vivo</i> mouse model of TB, we show that pharmacological inhibition of EGFR and BRD4 compromises LD build-up via enhanced lipophagy and normalizes angiogenesis, thereby restricting Mtb burden and rescuing mice from severe TB-like pathology. These findings shed light on the novel roles of BRD4 during Mtb infection, and its possible implication in potentiating anti-TB responses.
DOI: 10.6084/m9.figshare.15028702.v1
title: Imbalanced autophagy causes synaptic deficits in a human model for neurodevelopmental disorders

description: Macroautophagy (hereafter referred to as autophagy) is a finely tuned process of programmed degradation and recycling of proteins and cellular components, which is crucial in neuronal function and synaptic integrity. Mounting evidence implicates chromatin remodeling in fine-tuning autophagy pathways. However, this epigenetic regulation is poorly understood in neurons. Here, we investigate the role in autophagy of KANSL1, a member of the nonspecific lethal complex, which acetylates histone H4 on lysine 16 (H4K16ac) to facilitate transcriptional activation. Loss-of-function of KANSL1 is strongly associated with the neurodevelopmental disorder Koolen-de Vries Syndrome (KdVS). Starting from KANSL1-deficient human induced-pluripotent stem cells, both from KdVS patients and genome-edited lines, we identified SOD1 (superoxide dismutase 1), an antioxidant enzyme, to be significantly decreased, leading to a subsequent increase in oxidative stress and autophagosome accumulation. In KANSL1-deficient neurons, autophagosome accumulation at excitatory synapses resulted in reduced synaptic density, reduced GRIA/AMPA receptor-mediated transmission and impaired neuronal network activity. Furthermore, we found that increased oxidative stress-mediated autophagosome accumulation leads to increased MTOR activation and decreased lysosome function, further preventing the clearing of autophagosomes. Finally, by pharmacologically reducing oxidative stress, we could rescue the aberrant autophagosome formation as well as synaptic and neuronal network activity in KANSL1-deficient neurons. Our findings thus point toward an important relation between oxidative stress-induced autophagy and synapse function, and demonstrate the importance of H4K16ac-mediated changes in chromatin structure to balance reactive oxygen species- and MTOR-dependent autophagy. <b>Abbreviations</b>: APO: apocynin; ATG: autophagy related; BAF: bafilomycin A<sub>1</sub>; BSO: buthionine sulfoximine; CV: coefficient of variation; DIV: days in vitro; H4K16ac: histone 4 lysine 16 acetylation; iPSC: induced-pluripotent stem cell; KANSL1: KAT8 regulatory NSL complex subunit 1; KdVS: Koolen-de Vries Syndrome; LAMP1: lysosomal associated membrane protein 1; MAP1LC3/LC3: microtubule associated protein 1 light chain 3; MEA: micro-electrode array; MTOR: mechanistic target of rapamycin kinase; NSL complex: nonspecific lethal complex; 8-oxo-dG: 8-hydroxydesoxyguanosine; RAP: rapamycin; ROS: reactive oxygen species; sEPSCs: spontaneous excitatory postsynaptic currents; SOD1: superoxide dismutase 1; SQSTM1/p62: sequestosome 1; SYN: synapsin; WRT: wortmannin.
DOI: 10.17632/x3dtjrf8np.1
title: Supplementary Table I: Example of a process map

description: Example of a Process Map or Flowchart
DOI: 10.17632/89x8s56p5z.1
title: The Efficacy and Safety of Janus Kinase Inhibitors in Patients with Atopic Dermatitis: A Systematic Review and Meta-analysis

description: These data is a supplementary data for a manuscript entitled "The Efficacy and Safety of Janus Kinase Inhibitors in Patients with Atopic Dermatitis: A Systematic Review and Meta-analysis". In this study, we showed that JAK inhibitors are a promising treatment option for AD. Due to the higher risk of gastrointestinal disorders, nasopharyngitis and headache during oral JAKi treatments, more attention should be paid on the adverse effects of patients treated with oral JAKi. Further studies with long follow-up in the different conditions will be needed to fully elucidate the safety profile of the different JAK inhibitors.
DOI: 10.17632/3njxchzht8.1
title: Data Set of Antimicrobial resistance and virulence genes of  invasive Salmonella enterica from Children in Northcentral Nigeria

description: Supplementary data to the work presented in an ongoing study on molecular characterization of  invasive Salmonella from pediatric population in Nigeria.
DOI: 10.17632/5ppm9ph565.1
title: Trace elements dataset in marine sediments along Egyptian shores

description: A comprehensive dataset concerning the geochemical composition of unconsolidated shallow marine sediments collected along coastal areas of Northern Nile Delta and Egyptian sector of Red Seas is presented.
DOI: 10.17632/9m3bg3h5rs.1
title: Özden_et_al_MDfiles

description: MD simulation files from Özden et al 2022
DOI: 10.17632/hn3ssxw3pp.4
title: Intralesional measles, mumps, rubella vaccine versus tuberculin purified protein derivative injections in the treatment of palmoplantar and periungual warts: A double-blind randomized controlled trial

description: Supplementary materials of the study entitled "Intralesional measles, mumps, rubella vaccine versus tuberculin purified protein derivative injections in the treatment of palmoplantar and periungual warts: A double-blind randomized controlled trial"
DOI: 10.17632/9jf5gphm7z.1
title: Tourism Arrivals in East African Community 2000 to 2019

description: This data reflects tourism trends ten years after singing of the Treaty establishing the East African Community, and ten years after with the ratification of the Free Movement Protocol. It was used to understand how regional integration affects tourism arrivals using the political economy of East African Community.
DOI: 10.17632/p6why23swc.1
title: FACTORS THAT AFFECT THE INVESTORS’ INTENTION TO ADOPT ROBO-ADVISOR IN MALAYSIA 

description: Our research intend to empirically test the following hypotheses :

H1:	There is a relationship between transparency and the investor’s intention to adopt robo-advisory services.
H2: 	There is a relationship between relative advantage and the investor’s intention to adopt robo-advisory services.
H3: 	There is a relationship between social influence and the investor’s intention to adopt robo-advisory services.
H4: 	There is a relationship between perceived usefulness and the investor’s intention to adopt robo-advisory services.
H5: 	There is a relationship between effort expectancy and the investor’s intention to adopt robo-advisory services.

The data was collected via an online survey questionnaire. The likert scale data collected are based upon the above hypotheses are they are related to the constructs i.e. transparency, relative advantage, social influence, perceived usefulness and effort expectancy. 
In this research, we have also identified several variables which predict Malaysian citizens’ intention to adopt this new technology. We found significant relationships between transparency, relative advantage, social influence, and perceived usefulness in the adoption of robo-advisory services in Malaysia. However, there is no significant relationship between effort expectancy and intention to adopt robo-advisory services in Malaysia.
DOI: 10.17632/frkvyhmz2f.1
title: Data from: Population structure and microhabitat preference of a threatened freshwater mussel, Westralunio carteri, in south-western Australia

description: The Excel file “Mussel_quadrat_data” contains data relating to number of mussels and microhabitat variables in quadrat samples from rivers in Western Australia. Each row provides the information from one quadrat. Data include: Number of mussels per quadrat (Mussel #); River; Site within river; Distance to riverbank (BD); Water depth (WD); Riverbed slope (BS); Presence of debris (DP); Debris height (DH); Flow velocity (FV); Substrate grain size (SG); Vegetation cover (VC); Macrophyte cover (MC); Algal cover (AC)
DOI: 10.17632/hdkhhsjv8n.2
title: Malignant progression of liver cancer progenitors requires KAT7-acetylated and cytoplasm-translocated G-protein GαS

description: Malignant progression of liver cancer progenitors requires KAT7-acetylated and cytoplasm-translocated G-protein GαS
DOI: 10.17632/8msn4kxknp.1
title: Kappa_RH_JGR_PSzhao

description: This data repository inlucdes datasets for the paper published by PSzhao and YeKuang about the hygroscopicty relative humidity dependence of ambient aerosols.
DOI: 10.17632/8cwzbsphkj.1
title: GGO Cryoablation Lung Function data

description: Cryoablation may serve as a safe and feasible option for the treatment of lung nodules mainly composed of GGOs.
Forced expiratory volume in the first second (FEV1), forced vital capacity (FVC), and the FEV1/FVC ratio were measured before, 1 week after, and 1 month after the cryoablation treatment. All patients received pulmonary function testing three times and the highest FEV1 value was included in this study. The error rate was less than 5% as determined by measurements recorded in triplicate.
DOI: 10.17632/pb9xfsp4tw.2
title: Abiotic stress induced “common-alarm signals” in plants

description: Thus, to interpret the involvement of ROS in stress signalling, the publicly available transcriptome datasets from selected AEM encoding genes of Arabidopsis thaliana including aox1a (mitochondria; (Umbach et al., 2005), cat2 (chloroplast, peroxisome and mitochondria; (Vanderauwera et al., 2005), sal1 (chloroplast and mitochondria; (Wilson et al., 2009), tapx (chloroplast; (Maruta et al., 2012), vtc1 (cytoplasm and nucleus; (Foyer et al., 2012; Pastori et al., 2003) and vtc2 (cytoplasm and nucleus; (Foyer et al., 2012) were utilized for analysis. There are atleast 50% overlap between the differentially expressed genes (DEGs) in Arabidopsis mutants including tapx, cat2, aox1a, vtc1 and vtc2 (Fig. 2A-B). The highest number of up- and down-regulated DEGs was observed in sal1 mutant, indicating it as one of the key regulators of nuclear gene expression. The other mutants follow the order of vtc2>tapx>vtc1>aox1>cat2, as per the total number of DEGs (Fig 2A). The median value indicated that the maximum change in gene expression in cat2, followed by sal1>tapx>vtc2>vtc1>aox1 and sal1>vtc1>vtc2>tapx>aox1 in case of up- and down-regulated genes, respectively (Fig. 2A). Thus, the maximum impact on nuclear gene expression was noticed under sal1 (as per DEGs number) and cat2 (as per expression change), which were incidentally having multiple sub-cellular localization.
DOI: 10.17632/zw4p9kj6nt.1
title: Mosquito-on-human-skin

description: A mosquito images dataset that suitable for training and evaluating a recognition systems for the mosquito on human skin. Images of mosquito were obtained from a WHO accredited breeding laboratory, therefore validated the process of data annotation. There are three species of mosquitoes (Aedes aegypti,  Aedes albopictus, Culex quinquefasciatus) in two conditions (normal landing and smashed from). Therefore, six classes of the images were obtained from the dataset construction.
DOI: 10.17632/m4s8vkd8c5.2
title: Data from uniaxial compressive testing of laboratory-made granular ice 

description: Uniaxial compressive tests of laboratory-made granular ice were conducted in a cold room in the ductile and brittle strain rate range at -10.83°C ±0.74°C. Ice specimens with a length to diameter ratio of 2.5 showing brittle behavior failed by axial splitting. With the Instron Labtronic 8800, the operator controlled the tests at a frequency of 4,000 Hz. The data acquisition rate was 25,000 Hz, and for faster experiments, 100,000 Hz. The operator controlled on a random basis the hydraulic cylinder by either the cylinder displacement or the specimen displacement to investigate the influence of the testing stiffness, among other testing properties, on the compressive strength of ice. The aim of the investigations was also to show the influence of high strain rates (brittle behavior) on the compressive strength of ice. Increasing as well as constant and decreasing compression strength trends with increasing strain rates could be shown in the past. The data presented here show a lower compressive strength at strain rates higher than 4*10-3 s-1. The data consist of the time history of the specimen and cylinder displacement measurement (in mm), and the force measurement (in kN). The data is available as a separate .xlsx file for each test performed. In total, 123 tests were performed. The file labeling consists of the testing date, the test number within the test series, the set test velocity (in mm/s) and the type of cylinder control. For the cylinder displacement controlled test, the label ends with ‘CDC’ and for the specimen displacement controlled tests, the label ends with ‘SDC’. However, if the test was performed with a 10 mm gap, the label ends with a ‘g’. The abbreviations are separated with an underscore.
The data provided here can be used to validate ice-material models or for ice-testing databases for machine learning purposes.
DOI: 10.17632/k8y4tt9682.1
title: Raw data-Impact of Breast Tumor Onset on Blood Count, Carcinoembryonic Antigen, Cancer Antigen 15-3 and Lymphoid Subpopulations Supported by Automatic Classification Approach

description: raw data of the research work
DOI: 10.17632/94rh86jfpk.3
title: Supplementary data related to the quality validations of simulated protein-ligand complexes and SYBYL docking scores of bioactive natural compounds as inhibitors of Mycobacterium tuberculosis protein-targets

description: This supplementary raw data set belongs to the article entitled "Datasets comprising the quality validations of simulated protein-ligand complexes and SYBYL docking scores of bioactive natural compounds as inhibitors of Mycobacterium tuberculosis protein-targets" in Data in Brief journal. This data set comprises raw docking scores and simulation data to reproduce images cited in the manuscript.
DOI: 10.17632/ynwmjpj82n.1
title: Fishing Capacity and Economic Profile of Commercial Fishing Vessels in Kuantan, Pahang State, East Coast of Peninsular Malaysia

description: The marine capture fishery in Malaysia contributed significantly to the national economy and inshore fishery is the main contributor of the fish landings. The importance of marine fisheries is not only for the political and social also for the ecological aspect concerning with economy and well-being of the coastal communities. Moreover, the long-term sustainability of marine fisheries calls for the maintaining and important consideration upon it. Due to the complex system of marine and coastal area, the interaction among the fish population, economy and management policy are crucially need to evaluated. 
The main focus of the research is modelling fishing fleet dynamic and fishermen behavior. Therefore, the behavior of fishermen with respect to over-fishing and the impact of current management policy; and simulation the dynamics of fishing fleet using the proposed management policies with the aim of sustainable fishery management practices are the main expected outcomes by the research. 
Therefore, hypotheses could be stated in the study:
H(1): The fishing effort by each vessel and overall fishing fleet, which directly changes with the profit of fishing vessel more fishing fleet will enter the industry with increasing profit.
H(2):  The proper combination of management policies will address the profit maximization and sustainable fishery management in the long run.
Therefore, the research questions include:
-How fishermen behave on short term and long term effort allocation and key fishermen behavior of entry and exit decisions to achieve the desired socioeconomic and biological objectives; and
-How fishermen behave in line with the profit maximization and impact of management policies and what is the proper combination of fishery management policies with the aim of sustainable fisheries management.

-	The data presents the economic profile and performance capacity of commercial fishing vessels. These data are useful to predict the number of catches and provide information about value in economic analyses, to predict the performance and contribution of commercial fishery to the economic development. These data been collected from the trawl and purse seine fishers at the commercial fishing industry at East Coast of Peninsular Malaysia. The data could be used for the economic management of commercial fishing industry with different stakeholders including fisheries department and other institutions.   

-	The data will be highly beneficial for the researcher who focus on the commercial fishing industry studies. 
-	These data can be used for further insights to produce recommended policies in the fishing industries.
-	The data can be used to characterize the need of economic analysis precisely. It helps to identify the commercial fishing vessels cost and expenditure. 
-	These data show the income of crew depends on the type of vessels and gear types and will explains the percentage and share that been split for the income.
DOI: 10.17632/swd5bh5r38.1
title: Raw data-Peptide-Based Hydrogels and Nanogels for Delivery of Doxorubicin

description: raw data of the research work
DOI: 10.25919/1szg-5b66
title: Parkes observations for project PX500 semester 2021OCTS_33

description: This proposal relates to time purchased by the Chinese Academy of Sciences for Parkes follow-up confirmation and timing of FAST discoveries. As the observing time has been purchased this proposal (and the related PX501) does not require TAC grading. The primary reason for submitting a proposal is to ensure an outreach statement and that the proposal is entered into OPAL for the data archive to access. The Chinese team have two time requests. The time scheduled for the first, relating to this proposal, will be allocated in blocks of 24 hours and the data will become available in the data archive with an 18 month embargo period. The second type of time will be scheduled in shorter blocks and the data archived with a 10 year embargo.
DOI: 10.17632/w7rs8h9j8t.1
title: Raw data-Members of the GADD45 protein family show distinct propensities to form toxic amyloid-like aggregates in physiological conditions

description: Raw data of the research work
DOI: 10.17632/z3sww67w9x.1
title: Raw data-Investigating Dual-Energy CT Post-Contrast Phases for Liver Iron Quantification

description: other raw data of the work are in a repository of the Institute, for information contact dario.baldi@synlab.it
DOI: 10.17632/bmp9wtyx37.1
title: Supplementary materials: Key genes and regulatory networks of hypoxic preconditioning on osteoblasts

description: Supplementary materials: Key genes and regulatory networks of hypoxic preconditioning on osteoblasts.
DOI: 10.17632/p6sfdpjpj2.1
title: Jeong et al, 2022, Measurement of ciliary beating and fluid flow in the zebrafish adult telencephalon

description: In this dataset, we are providing MATLAB codes to analyse ciliary beating and cerebrospinal fluid flow in the zebrafish forebrain. Test datasets are also included. Please refer to the manuscript text Jeong et al, STAR protocol, 2022 for more details on how to use the codes and the expected outcomes.
DOI: 10.17632/zgytmbrnr2.1
title: Long-term follow-up data on three siblings with a novel NNT duplication mutation causing primary adrenal insuficiency

description: We performed a long-term follow-up of three sibling that were found to be homozygous for a novel duplication mutation in the NNT gene, encoding nicotinamide nucleotide transhydrogenase (NNT). Lack of a functional NNT protein results in primary adrenal insuficiency and also some other extra-adrenal manifestations.

All three brothers were managed as out- and in-patients at the University Children's Hospital, University Medical Centre Ljubljana. They presented to us at the age of 1.4, 1.1 years and 2 monts. Their age at last follow-up was 21.6, 20.2 and 4.2 years. Patients 1 and 2 presented with Addisonian crisis.

In this dataset, we provide the raw data on:
- Laboratory values at first presentation,
- Laboratory values through follow-up,
- Bone mineral density,
- Growth (height, weight, BMI),
- Hydrocortisone treatment,
- ACTH stimulation test,
- GnRH stimulation test.

The main findings were:
- all three brothers who were homozygous for a novel mutation in NNT gene developed isolated glucocorticoid deficiency,
- acute adrenal crisis developed in patients 1 and 2 after the first year of life,
- patient 3 was identified at the age of 2 months in the asymptomatic stage,
- none had mineralocorticoid deficiency,
- thyroid function was normal,
- testicular volume was somewhat lower than expected for their age, but testosteron, inhibin B and GnRH test results were appropriate,
- low bone mineral density was observed in patients 1 and 2.
DOI: 10.17632/2z6pjpttcy.1
title: Full-volatility emission framework corrects missing and underestimated secondary organic aerosol sources. Chang et al.

description: This dataset provides the organic emission inventory with full volatility coverage for China 2017.
The xlsx file is the provincial sectoral emissions in different volatility bins. 
The txt files are gridded emission for each volatility range. Each column represents a emission source sector, and each row represents a grid. The grids are arranged in a row-major sequence starting at the left-bottom corner of the mesh (i.e. the first row in the file represents emissions of the 1st row and 1st column at the south-west corner, the second row in the file represents the 1st row and 2nd column, and so on). The emissions are all in t/grid/year. One may refer to the GRIDCRO2D_cn27_2018001 file for the geographic information of the grids. This file is generated by MCIP based on WRF simulation.
Emission source sectors:
PPCB: power plants
INCB: industrial combustion
PROT: industrial process
DOFU: domestic fossil fuel combustion
DOBI: domestic biomass combustion
OPEN: biomass open burning
TRDE: on-road diesel transportation
TRGS: on-road gasoline transportation
TROF: off-road transportation
DOSO: domestic VCPs
PRSO: industrial VCPs
DOTH: other VOC sources
DOI: 10.17632/z7fdnhfdx4.1
title: Tirado-Olivares et al. (2022) Revisión Innovagogía 2022

description: Documentos seleccionados en el estudio preliminar de la revisión de la literatura sobre el uso de Learning Analytics en K-12 presentado en Innovagogía (2022).
DOI: 10.17632/czhndxtnyn.1
title: Raw data-Fabrication of fluorescent nanospheres by heating PEGylated tetratyrosine nanofibers

description: raw data of the research work