cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.4057695
title: Predicting Lexical Priming Effects from Distributional Semantic Similarities: A Replication with Extension

description: Data sets, variable descriptions and R scripts for the following article:<br><br>Günther, F., Dudschig, C., & Kaup, B. (2016). Predicting lexical priming effects from distributional semantic similarities: A replication with extension. Frontiers in Psychology, 7, 1646.<br><br>doi: http://dx.doi.org/10.3389/fpsyg.2016.01646
DOI: 10.7910/dvn/v1rjpf/d2uljk
title: blc20150503_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.4057686
title: Complex networks of GitHub authors in Andalusía, Spain

description: Analysis of social networks in several provinces in Andalucía, with nodes being GitHub IDs and edges joining users working in the same repository. Data was taken in May 2016 and analyzed using Gephi.<br>Two of the cities with the most users Granada and Seville, have been also represented. <br>
DOI: 10.6084/m9.figshare.4057695.v1
title: Predicting Lexical Priming Effects from Distributional Semantic Similarities: A Replication with Extension

description: Data sets, variable descriptions and R scripts for the following article:<br><br>Günther, F., Dudschig, C., & Kaup, B. (2016). Predicting lexical priming effects from distributional semantic similarities: A replication with extension. Frontiers in Psychology, 7, 1646.<br><br>doi: http://dx.doi.org/10.3389/fpsyg.2016.01646
DOI: 10.6084/m9.figshare.4057653
title: Combined assimilation of streamflow and snow water equivalent for mid-term ensemble streamflow forecasts in snow-dominated regions

description: Contains synthetic observations and meteorological input over the Nechako watershed for the period 1985-2000 used in the study :<br>Bergeron, J. M., Trudel, M., and Leconte, R.: Combined assimilation of streamflow and snow water equivalent for mid-term ensemble streamflow forecasts in snow-dominated regions, Hydrol. Earth Syst. Sci. Discuss., doi:10.5194/hess-2016-166, in review, 2016.
DOI: 10.6084/m9.figshare.4057686.v1
title: Complex networks of GitHub authors in Andalusía, Spain

description: Analysis of social networks in several provinces in Andalucía, with nodes being GitHub IDs and edges joining users working in the same repository. Data was taken in May 2016 and analyzed using Gephi.<br>Two of the cities with the most users Granada and Seville, have been also represented. <br>
DOI: 10.7910/dvn/v1rjpf/19qqvn
title: blc20151014_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.4057653.v1
title: Combined assimilation of streamflow and snow water equivalent for mid-term ensemble streamflow forecasts in snow-dominated regions

description: Contains synthetic observations and meteorological input over the Nechako watershed for the period 1985-2000 used in the study :<br>Bergeron, J. M., Trudel, M., and Leconte, R.: Combined assimilation of streamflow and snow water equivalent for mid-term ensemble streamflow forecasts in snow-dominated regions, Hydrol. Earth Syst. Sci. Discuss., doi:10.5194/hess-2016-166, in review, 2016.
DOI: 10.7910/dvn/v1rjpf/olvwli
title: blc20150624_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/pwu7dz
title: blc20151121_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/sbqede
title: blc20150723_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.4056732
title: RNA-binding proteins are a major target of silica nanoparticles in cell extracts

description: Upon contact with biological fluids, nanoparticles (NPs) are readily coated by cellular compounds, particularly proteins, which are determining factors for the localization and toxicity of NPs in the organism. Here, we improved a methodological approach to identify proteins that adsorb on silica NPs with high affinity. Using large-scale proteomics and mixtures of soluble proteins prepared either from yeast cells or from alveolar human cells, we observed that proteins with large unstructured region(s) are more prone to bind on silica NPs. These disordered regions provide flexibility to proteins, a property that promotes their adsorption. The statistical analyses also pointed to a marked overrepresentation of RNA-binding proteins (RBPs) and of translation initiation factors among the adsorbed proteins. We propose that silica surfaces, which are mainly composed of Si–O<sup>−</sup> and Si–OH groups, mimic ribose-phosphate molecules (rich in –O<sup>−</sup> and –OH) and trap the proteins able to interact with ribose-phosphate containing molecules. Finally, using an <i>in vitro</i> assay, we showed that the sequestration of translation initiation factors by silica NPs results in an inhibition of the <i>in vitro</i> translational activity. This result demonstrates that characterizing the protein corona of various NPs would be a relevant approach to predict their potential toxicological effects.
DOI: 10.6084/m9.figshare.4056699
title: R codes associated to Lacasella et al., 'From pest data to abundance-based risk maps combining eco-physiological knowledge, weather and habitat variability'. Ecological Applications, accepted.

description: These R codes and files have to be considered as an electronic supplementary material of Lacasella et al. From pest data to abundance-based risk maps combining eco-physiological knowledge, weather and habitat variability. Ecological Applications, accepted.<br><br>You can consider Fig.1 in the above-mentioned paper as an additional pipeline of the scripts from 1# to 4#<br>
DOI: 10.6084/m9.figshare.4056732.v1
title: RNA-binding proteins are a major target of silica nanoparticles in cell extracts

description: Upon contact with biological fluids, nanoparticles (NPs) are readily coated by cellular compounds, particularly proteins, which are determining factors for the localization and toxicity of NPs in the organism. Here, we improved a methodological approach to identify proteins that adsorb on silica NPs with high affinity. Using large-scale proteomics and mixtures of soluble proteins prepared either from yeast cells or from alveolar human cells, we observed that proteins with large unstructured region(s) are more prone to bind on silica NPs. These disordered regions provide flexibility to proteins, a property that promotes their adsorption. The statistical analyses also pointed to a marked overrepresentation of RNA-binding proteins (RBPs) and of translation initiation factors among the adsorbed proteins. We propose that silica surfaces, which are mainly composed of Si–O<sup>−</sup> and Si–OH groups, mimic ribose-phosphate molecules (rich in –O<sup>−</sup> and –OH) and trap the proteins able to interact with ribose-phosphate containing molecules. Finally, using an <i>in vitro</i> assay, we showed that the sequestration of translation initiation factors by silica NPs results in an inhibition of the <i>in vitro</i> translational activity. This result demonstrates that characterizing the protein corona of various NPs would be a relevant approach to predict their potential toxicological effects.
DOI: 10.7910/dvn/v1rjpf/m9mnwh
title: blc20150816_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/ylhjim
title: blc20150908_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.4056663
title: Model Input Data of publication "Towards thresholds of disaster management performance under demographic change" (NHESS)

description: Model input data of publication <br>Dressler, G., Müller, B., Frank, K., Kuhlicke, C.: "Towards thresholds of disaster management performance under demographic change: exploring functional relationships using agent-based modeling", Natural Hazards and Earth System Sciences, 2016.<br>Contains the following datasets:<br>OpenStreetMap data of rivers and street network of the Free State of Saxony, Germany. Raw data obtained from Geofabrik (link see references).<br>Flood prone areas of the Free State of Saxony, Germany. Raw data obtained from Landesamt für Umwelt, Landwirtschaft and Geologie - LfULG (link see references).<br>All data has been preprocessed for two case sites using ArcGIS and prepared for use in a NetLogo simulation model.
DOI: 10.6084/m9.figshare.4056699.v1
title: R codes associated to Lacasella et al., 'From pest data to abundance-based risk maps combining eco-physiological knowledge, weather and habitat variability'. Ecological Applications, accepted.

description: These R codes and files have to be considered as an electronic supplementary material of Lacasella et al. From pest data to abundance-based risk maps combining eco-physiological knowledge, weather and habitat variability. Ecological Applications, accepted.<br><br>You can consider Fig.1 in the above-mentioned paper as an additional pipeline of the scripts from 1# to 4#<br>
DOI: 10.6084/m9.figshare.4056660
title: Performance and sleep measure data for Experiment from Perceptual impairment in face identification with poor sleep

description: Previous studies have shown impaired memory for faces following restricted sleep.
DOI: 10.6084/m9.figshare.4056660.v1
title: Performance and sleep measure data for Experiment from Perceptual impairment in face identification with poor sleep

description: Previous studies have shown impaired memory for faces following restricted sleep.
DOI: 10.6084/m9.figshare.4056663.v1
title: Model Input Data of publication "Towards thresholds of disaster management performance under demographic change" (NHESS)

description: Model input data of publication <br>Dressler, G., Müller, B., Frank, K., Kuhlicke, C.: "Towards thresholds of disaster management performance under demographic change: exploring functional relationships using agent-based modeling", Natural Hazards and Earth System Sciences, 2016.<br>Contains the following datasets:<br>OpenStreetMap data of rivers and street network of the Free State of Saxony, Germany. Raw data obtained from Geofabrik (link see references).<br>Flood prone areas of the Free State of Saxony, Germany. Raw data obtained from Landesamt für Umwelt, Landwirtschaft and Geologie - LfULG (link see references).<br>All data has been preprocessed for two case sites using ArcGIS and prepared for use in a NetLogo simulation model.
DOI: 10.7910/dvn/v1rjpf/4uu5eh
title: blc20150328_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.4056654
title: Table S2 Data Brewer Cook Bird from Alexithymia: a general deficit of interoception

description: Alexithymia is a sub-clinical construct, traditionally characterized by difficulties identifying and describing one's own emotions. Despite the clear need for interoception (interpreting physical signals from the body) when identifying one's own emotions, little research has focused on the selectivity of this impairment. While it was originally assumed that the interoceptive deficit in alexithymia is specific to emotion, recent evidence suggests that alexithymia may also be associated with difficulties perceiving some non-affective interoceptive signals, such as one's heart rate. It is therefore possible that the impairment experienced by those with alexithymia is common to all aspects of interoception, such as interpreting signals of hunger, arousal, proprioception, tiredness and temperature. In order to determine whether alexithymia is associated with selectively impaired affective interoception, or general interoceptive impairment, we investigated the association between alexithymia and self-reported non-affective interoceptive ability, and the extent to which individuals perceive similarity between affective and non-affective states (both measured using questionnaires developed for the purpose of the current study), in both typical individuals (<i>n</i> = 105 (89 female), mean age = 27.5 years) and individuals reporting a diagnosis of a psychiatric condition (<i>n</i> = 103 (83 female), mean age = 31.3 years). Findings indicated that alexithymia was associated with poor non-affective interoception and increased perceived similarity between affective and non-affective states, in both the typical and clinical populations. We therefore suggest that rather than being specifically associated with affective impairment, alexithymia is better characterized by a general failure of interoception.
DOI: 10.7910/dvn/v1rjpf/w3gmvc
title: blc20150826_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.4056654.v1
title: Table S2 Data Brewer Cook Bird from Alexithymia: a general deficit of interoception

description: Alexithymia is a sub-clinical construct, traditionally characterized by difficulties identifying and describing one's own emotions. Despite the clear need for interoception (interpreting physical signals from the body) when identifying one's own emotions, little research has focused on the selectivity of this impairment. While it was originally assumed that the interoceptive deficit in alexithymia is specific to emotion, recent evidence suggests that alexithymia may also be associated with difficulties perceiving some non-affective interoceptive signals, such as one's heart rate. It is therefore possible that the impairment experienced by those with alexithymia is common to all aspects of interoception, such as interpreting signals of hunger, arousal, proprioception, tiredness and temperature. In order to determine whether alexithymia is associated with selectively impaired affective interoception, or general interoceptive impairment, we investigated the association between alexithymia and self-reported non-affective interoceptive ability, and the extent to which individuals perceive similarity between affective and non-affective states (both measured using questionnaires developed for the purpose of the current study), in both typical individuals (<i>n</i> = 105 (89 female), mean age = 27.5 years) and individuals reporting a diagnosis of a psychiatric condition (<i>n</i> = 103 (83 female), mean age = 31.3 years). Findings indicated that alexithymia was associated with poor non-affective interoception and increased perceived similarity between affective and non-affective states, in both the typical and clinical populations. We therefore suggest that rather than being specifically associated with affective impairment, alexithymia is better characterized by a general failure of interoception.
DOI: 10.7910/dvn/v1rjpf/vyxl9u
title: blc20150321_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/xfrqjd
title: blc20150109_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.4056630
title: The actin binding proteins cortactin and HS1 are dispensable for platelet actin nodule and megakaryocyte podosome formation

description: A dynamic, properly organised actin cytoskeleton is critical for the production and haemostatic function of platelets. The Wiskott Aldrich Syndrome protein (WASp) and Actin-Related Proteins 2 & 3 Complex (Arp2/3 complex) are critical mediators of actin polymerisation and organisation in many cell types. In platelets and megakaryocytes, these proteins have been shown to be important for proper platelet production and function. The cortactin family of proteins (Cttn & HS1) are known to regulate WASp-Arp2/3-mediated actin polymerisation in other cell types and so here we address the role of these proteins in platelets using knockout mouse models. We generated mice lacking Cttn and HS1 in the megakaryocyte/platelet lineage. These mice had normal platelet production, with platelet number, size and surface receptor profile comparable to controls. Platelet function was also unaffected by loss of Cttn/HS1 with no differences observed in a range of platelet function assays including aggregation, secretion, spreading, clot retraction or tyrosine phosphorylation. No effect on tail bleeding time or in thrombosis models was observed. In addition, platelet actin nodules, and megakaryocyte podosomes, actin-based structures known to be dependent on WASp and the Arp2/3 complex, formed normally. We conclude that despite the importance of WASp and the Arp2/3 complex in regulating F-actin dynamics in many cells types, the role of cortactin in their regulation appears to be fulfilled by other proteins in platelets.
DOI: 10.7910/dvn/v1rjpf/oiysga
title: blc20150917_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.4056630.v1
title: The actin binding proteins cortactin and HS1 are dispensable for platelet actin nodule and megakaryocyte podosome formation

description: A dynamic, properly organised actin cytoskeleton is critical for the production and haemostatic function of platelets. The Wiskott Aldrich Syndrome protein (WASp) and Actin-Related Proteins 2 & 3 Complex (Arp2/3 complex) are critical mediators of actin polymerisation and organisation in many cell types. In platelets and megakaryocytes, these proteins have been shown to be important for proper platelet production and function. The cortactin family of proteins (Cttn & HS1) are known to regulate WASp-Arp2/3-mediated actin polymerisation in other cell types and so here we address the role of these proteins in platelets using knockout mouse models. We generated mice lacking Cttn and HS1 in the megakaryocyte/platelet lineage. These mice had normal platelet production, with platelet number, size and surface receptor profile comparable to controls. Platelet function was also unaffected by loss of Cttn/HS1 with no differences observed in a range of platelet function assays including aggregation, secretion, spreading, clot retraction or tyrosine phosphorylation. No effect on tail bleeding time or in thrombosis models was observed. In addition, platelet actin nodules, and megakaryocyte podosomes, actin-based structures known to be dependent on WASp and the Arp2/3 complex, formed normally. We conclude that despite the importance of WASp and the Arp2/3 complex in regulating F-actin dynamics in many cells types, the role of cortactin in their regulation appears to be fulfilled by other proteins in platelets.
DOI: 10.7910/dvn/v1rjpf/scpnik
title: blc20150314_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/m8vkfv
title: blc20151224_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/6ubftg
title: blc20151230_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/lywblj
title: blc20151109_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/cbotqr
title: blc20150425_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/b7fbth
title: blc20150103_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/vnr6ob
title: blc20150831_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/omloj4
title: blc20151011_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/rqggxp
title: blc20150618_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/3l6fir
title: blc20150609_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/m5q3oq
title: blc20150301_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.4056564
title: Supplementary Material for: Trends in Anemia Management in Hemodialysis Patients with Cancer

description: <br><strong><em>Background:</em></strong> Erythropoiesis-stimulating agents (ESAs), intravenous iron, and blood transfusion are used to treat anemia in both end-stage renal disease (ESRD) and cancer. However, anemia treatment patterns have not been described among ESRD patients undergoing hemodialysis with concurrent cancer, especially in the recent era of ESA-related safety concerns. <b><i>Methods:</i></b> We analyzed Medicare data from a cohort of hemodialysis patients diagnosed with incident cancer. We used multivariable generalized linear models to estimate trends and patterns in ESA use, iron use, transfusion use, epoetin alfa (EPO) dose, iron dose, and resulting hemoglobin levels (2000-2011). <b><i>Results:</i></b> Of 43,760 eligible patients, quarterly ESA use declined slightly from a peak of 94.1 to 90.0%. Quarterly EPO dose increased from 2000 to 2004, then declined; quarterly hemoglobin levels followed a similar pattern. Iron use increased rapidly from 46.9 to 79.3%. Iron dose increased until 2010 and then declined. There was an increase in the quarterly transfusion use (6.3-11.7%) and in the mean number of transfusion days per year (1.4-1.8). Anemia treatment patterns varied by demographic/clinical subgroups, especially among patients receiving chemotherapy, who required higher ESA use, EPO dose, and frequency of transfusions. <b><i>Conclusions:</i></b> Despite safety concerns about ESAs in both the ESRD and cancer populations, the proportion of hemodialysis patients with cancer who used ESAs between 2000 and 2011 remained extremely high. EPO dose and hemoglobin levels increased and then decreased. Iron use, iron dose, and transfusions increased substantially. Future research examining the risk-benefit profile of different anemia management strategies in the dialysis population with cancer is needed.
DOI: 10.7910/dvn/v1rjpf/w2j7pi
title: blc20150130_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.4056564.v1
title: Supplementary Material for: Trends in Anemia Management in Hemodialysis Patients with Cancer

description: <br><strong><em>Background:</em></strong> Erythropoiesis-stimulating agents (ESAs), intravenous iron, and blood transfusion are used to treat anemia in both end-stage renal disease (ESRD) and cancer. However, anemia treatment patterns have not been described among ESRD patients undergoing hemodialysis with concurrent cancer, especially in the recent era of ESA-related safety concerns. <b><i>Methods:</i></b> We analyzed Medicare data from a cohort of hemodialysis patients diagnosed with incident cancer. We used multivariable generalized linear models to estimate trends and patterns in ESA use, iron use, transfusion use, epoetin alfa (EPO) dose, iron dose, and resulting hemoglobin levels (2000-2011). <b><i>Results:</i></b> Of 43,760 eligible patients, quarterly ESA use declined slightly from a peak of 94.1 to 90.0%. Quarterly EPO dose increased from 2000 to 2004, then declined; quarterly hemoglobin levels followed a similar pattern. Iron use increased rapidly from 46.9 to 79.3%. Iron dose increased until 2010 and then declined. There was an increase in the quarterly transfusion use (6.3-11.7%) and in the mean number of transfusion days per year (1.4-1.8). Anemia treatment patterns varied by demographic/clinical subgroups, especially among patients receiving chemotherapy, who required higher ESA use, EPO dose, and frequency of transfusions. <b><i>Conclusions:</i></b> Despite safety concerns about ESAs in both the ESRD and cancer populations, the proportion of hemodialysis patients with cancer who used ESAs between 2000 and 2011 remained extremely high. EPO dose and hemoglobin levels increased and then decreased. Iron use, iron dose, and transfusions increased substantially. Future research examining the risk-benefit profile of different anemia management strategies in the dialysis population with cancer is needed.
DOI: 10.6084/m9.figshare.4056555
title: Supplementary Material for: Histaminergic H3-Heteroreceptors as a Potential Mediator of Betahistine-Induced Increase in Cochlear Blood Flow

description: <br><strong><em>Objective:</em></strong> Betahistine is a histamine-like drug that is considered beneficial in Ménière's disease by increasing cochlear blood flow. Acting as an agonist at the histamine H<sub>1</sub>-receptor and as an inverse agonist at the H<sub>3</sub>-receptor, these receptors as well as the adrenergic α<sub>2</sub>-receptor were investigated for betahistine effects on cochlear blood flow. <b><i>Materials and Methods:</i></b> A total of 54 Dunkin-Hartley guinea pigs were randomly assigned to one of nine groups treated with a selection of H<sub>1</sub>-, H<sub>3</sub>- or α<sub>2</sub>-selective agonists and antagonists together with betahistine. Cochlear blood flow and mean arterial pressure were recorded for 3 min before and 15 min after infusion. <b><i>Results:</i></b> Blockage of the H<sub>3</sub>- or α<sub>2</sub>-receptors caused a suppression of betahistine-mediated typical changes in cochlear blood flow or blood pressure. Activation of H<sub>3</sub>-receptors caused a drop in cochlear blood flow and blood pressure. H<sub>1</sub>-receptors showed no involvement in betahistine-mediated changes of cochlear blood flow. <b><i>Conclusion:</i></b> Betahistine most likely affects cochlear blood flow through histaminergic H<sub>3</sub>-heteroreceptors.
DOI: 10.7910/dvn/v1rjpf/j4r7eg
title: blc20151222_03.txt.gz

description: :unav