cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.5544445.v1
title: Dataset for: Estimation and inference in spatially varying coefficient models

description: Spatially varying coefficient models (SVCMs) are a classical tool to explore the spatial nonstationarity of a regression relationship for spatial data. In this paper, we study the estimation and inference in SVCMs for data distributed over complex domains. We use bivariate splines over triangulations to represent the coefficient functions. The estimators of the coefficient functions are consistent, and rates of convergence of the proposed estimators are established. A penalized bivariate spline estimation method is also introduced, in which a roughness penalty is incorporated to balance the goodness-of-fit and smoothness. In addition, we propose hypothesis tests to examine if the coefficient function is really varying over space or admits a certain parametric form. The proposed method is much more computationally efficient than the well-known geographically weighted regression technique and thus usable for analyzing massive datasets. The performance of the estimators and the proposed tests are evaluated by simulation experiments. An environmental data example is used to illustrate the application of the proposed method.
DOI: 10.6084/m9.figshare.5540485
title: Canopy Structural Complexity Metrics from Terrestrial LiDAR and Light Data from 11 Eastern US Forests

description: These data were collected during 2016 and 207 using portable canopy lidar and a Decagon handheld ceptometer. CSC data include measures of canopy rugosity, top rugosity, porosity, vegetation area index, mean leaf height, mean outer canopy height, max canopy height derived using the forestr R package (version 1.0.0). <br><br>Light data include LAI and fPAR. <br><br>Sites included are Arnot Forest, University of Virginia, Rice Rivers Center, and NEON tower plots at Harvard Forest, Mountain Lake Biological Station, Smithsonian Conservation Biology Institute, Smithsonian Environmental Center, University of Notre Dame Environmental Research Center, Talladega National Forest, Ordway-Swisher Biological Station
DOI: 10.6084/m9.figshare.5540470
title: Trends and variation in Prescribing of Low-Priority Medicines Identified by NHS England: A Cross-Sectional Study and Interactive Data Tool in English Primary Care

description: Data and analytic code from the above entitled paper. Most of the data are sorted and directly queried from Google Bigquery, which we plan to make publicly available at some point in the future.
DOI: 10.6084/m9.figshare.5540470.v1
title: Trends and variation in Prescribing of Low-Priority Medicines Identified by NHS England: A Cross-Sectional Study and Interactive Data Tool in English Primary Care

description: Data and analytic code from the above entitled paper. Most of the data are sorted and directly queried from Google Bigquery, which we plan to make publicly available at some point in the future.
DOI: 10.6084/m9.figshare.5540374
title: ASHG 2017 Businesses

description: List of exhibitors in #ASHG17 classified by the type of business they represent.
DOI: 10.6084/m9.figshare.5540455
title: CDS length distribution of unigenes of Henosepilachna vigintioctopunctata at different life stages

description: <b>CDS length distribution of unigenes of Henosepilachna vigintioctopunctata at different life stages</b><br>
DOI: 10.6084/m9.figshare.5540341
title: Machine learning reveals orbital interaction in materials

description: We propose a novel representation of materials named an ‘orbital-field matrix (OFM)’, which is based on the distribution of valence shell electrons. We demonstrate that this new representation can be highly useful in mining material data. Experimental investigation shows that the formation energies of crystalline materials, atomization energies of molecular materials, and local magnetic moments of the constituent atoms in bimetal alloys of lanthanide metal and transition-metal can be predicted with high accuracy using the OFM. Knowledge regarding the role of the coordination numbers of the transition-metal and lanthanide elements in determining the local magnetic moments of the transition-metal sites can be acquired directly from decision tree regression analyses using the OFM.
DOI: 10.6084/m9.figshare.5540341.v1
title: Machine learning reveals orbital interaction in materials

description: We propose a novel representation of materials named an ‘orbital-field matrix (OFM)’, which is based on the distribution of valence shell electrons. We demonstrate that this new representation can be highly useful in mining material data. Experimental investigation shows that the formation energies of crystalline materials, atomization energies of molecular materials, and local magnetic moments of the constituent atoms in bimetal alloys of lanthanide metal and transition-metal can be predicted with high accuracy using the OFM. Knowledge regarding the role of the coordination numbers of the transition-metal and lanthanide elements in determining the local magnetic moments of the transition-metal sites can be acquired directly from decision tree regression analyses using the OFM.
DOI: 10.6084/m9.figshare.5540374.v2
title: ASHG 2017 Businesses

description: List of exhibitors in #ASHG17 classified by the type of business they represent.
DOI: 10.6084/m9.figshare.5540359.v1
title: National Gallery (London), Exhibitions, 2006-2017

description: This datasets lists temporary exhibitions hosted at the National Gallery, London from the year 2006-7 to 2016-7.<br>It includes details of artistic period, space, sponsors, visitor numbers, dates and other information taken from the National Gallery website and published reports
DOI: 10.6084/m9.figshare.5540455.v2
title: egg-Unigene.blast.cds.fa.length.jpg

description: <b>Characterization</b><b> of transcriptome in the pest ladybird <i>Henosepilachna vigintioctopunctata</i></b>
DOI: 10.6084/m9.figshare.5540455.v3
title: CDS length distribution of Unigenes of Henosepilachna vigintioctopunctata at different life stages

description: <b>Characterization</b><b> of transcriptome in the pest ladybird <i>Henosepilachna vigintioctopunctata </i>at all life stages</b>
DOI: 10.6084/m9.figshare.5540359.v3
title: National Gallery (London), Exhibitions, 2006-2018

description: This datasets lists temporary exhibitions hosted at the National Gallery, London from the year 2006-7 to 2017-8.<br>It includes details of artistic period, space, sponsors, visitor numbers, dates and other information taken from the National Gallery website and published reports.<br>Full documentation is available in the accompanying rtf file.
DOI: 10.6084/m9.figshare.5540455.v5
title: CDS length distribution of unigenes of Henosepilachna vigintioctopunctata at different life stages

description: <b>CDS length distribution of unigenes of Henosepilachna vigintioctopunctata at different life stages</b><br>
DOI: 10.6084/m9.figshare.5540293.v2
title: The New Alchemy Infographic - Helping Scientists Increase the Impact of Their Own Work

description: This infographic represents the work reported in the paper "The new alchemy: Online networking, data sharing and research activity distribution tools for scientists". <br>The abstract for the paper is: There is an abundance of free online tools accessible to scientists and others that can be used for online networking, data sharing and measuring research impact. Despite this, few scientists know how these tools can be used or fail to take advantage of using them as an integrated pipeline to raise awareness of their research outputs. In this article, the authors describe their experiences with these tools and how they can make best use of them to make their scientific research generally more accessible, extending its reach beyond their own direct networks, and communicating their ideas to new audiences. These efforts have the potential to drive science by sparking new collaborations and interdisciplinary research projects that may lead to future publications, funding and commercial opportunities. The intent of this article is to: describe some of these freely accessible networking tools and affiliated products; demonstrate from our own experiences how they can be utilized effectively; and, inspire their adoption by new users for the benefit of science.
DOI: 10.6084/m9.figshare.5540455.v4
title: Supplementary Figure S1 CDS length distribution of unigenes of Henosepilachna vigintioctopunctata at different life stages

description: <b>CDS length distribution of unigenes of Henosepilachna vigintioctopunctata at different life stages</b><br>
DOI: 10.6084/m9.figshare.5540116
title: Lignin-Carbohydrate.pdf

description: Total production of APPL and lignin:carbohydrate ratio obtained from wheat straw fermented with <i>S. ipomoeae</i> wild-type and mutant strains and from an un-inoculated wheat straw.
DOI: 10.6084/m9.figshare.5540098
title: Early short-term treatment with exogenous hydrogen sulfide postpones the transition from prehypertension to hypertension in spontaneously hypertensive rat

description: Hydrogen sulfide (H<sub>2</sub>S), nitric oxide (NO), and renin–angiotensin system (RAS) are involved in hypertension. We examined whether early treatment with sodium hydrosulfide (NaHS), an exogenous H<sub>2</sub>S donor, can regulate H<sub>2</sub>S-generating pathway, NO pathway, and the RAS, to prevent the transition from prehypertension to hypertension in spontaneously hypertensive rats (SHRs). Four-week-old SHRs and control normotensive Wistar–Kyoto (WKY) rats were assigned into three groups: WKY, SHRs, and SHR + NaHS; SHRs were injected intraperitoneally with sodium hydrosulfide (14 μmol/kg/day) for 4 weeks. SHRs exhibited hypertension at 12 weeks of age, which was blocked by early sodium hydrosulfide administration. Concentrations of H<sub>2</sub>S were increased in the kidney in SHR + NaHS group versus WKY. Sodium hydrosulfide reduces mRNA expression of four H<sub>2</sub>S-generating enzymes and decreased 3-mercaptopyruvate sulphurtransferase protein level in SHRs. Early administration of sodium hydrosulfide decreases plasma N<sup>G</sup> monomethyl-l-arginine (l-NMMA, an inhibitor of NO synthase) level and increases plasma NO level in SHRs. Next, sodium hydrosulfide administration reduces renal mRNA expression of <i>Ren, Atp6ap2, Agt, Ace</i>, and <i>Agtr1a</i> in SHRs. We conclude that early short-term sodium hydrosulfide treatment increases renal H<sub>2</sub>S concentrations, restores NO bioavailability, and blocks the RAS in the kidney, in favor of vasodilatation to prevent the development of hypertension in adult SHRs.
DOI: 10.6084/m9.figshare.5540098.v1
title: Early short-term treatment with exogenous hydrogen sulfide postpones the transition from prehypertension to hypertension in spontaneously hypertensive rat

description: Hydrogen sulfide (H<sub>2</sub>S), nitric oxide (NO), and renin–angiotensin system (RAS) are involved in hypertension. We examined whether early treatment with sodium hydrosulfide (NaHS), an exogenous H<sub>2</sub>S donor, can regulate H<sub>2</sub>S-generating pathway, NO pathway, and the RAS, to prevent the transition from prehypertension to hypertension in spontaneously hypertensive rats (SHRs). Four-week-old SHRs and control normotensive Wistar–Kyoto (WKY) rats were assigned into three groups: WKY, SHRs, and SHR + NaHS; SHRs were injected intraperitoneally with sodium hydrosulfide (14 μmol/kg/day) for 4 weeks. SHRs exhibited hypertension at 12 weeks of age, which was blocked by early sodium hydrosulfide administration. Concentrations of H<sub>2</sub>S were increased in the kidney in SHR + NaHS group versus WKY. Sodium hydrosulfide reduces mRNA expression of four H<sub>2</sub>S-generating enzymes and decreased 3-mercaptopyruvate sulphurtransferase protein level in SHRs. Early administration of sodium hydrosulfide decreases plasma N<sup>G</sup> monomethyl-l-arginine (l-NMMA, an inhibitor of NO synthase) level and increases plasma NO level in SHRs. Next, sodium hydrosulfide administration reduces renal mRNA expression of <i>Ren, Atp6ap2, Agt, Ace</i>, and <i>Agtr1a</i> in SHRs. We conclude that early short-term sodium hydrosulfide treatment increases renal H<sub>2</sub>S concentrations, restores NO bioavailability, and blocks the RAS in the kidney, in favor of vasodilatation to prevent the development of hypertension in adult SHRs.
DOI: 10.6084/m9.figshare.5540029
title: Untitled Item

description: tryptophan biosensor based on leader (nascent) peptide mechanism with mCherry as control.
DOI: 10.6084/m9.figshare.5540029.v1
title: Untitled Item

description: tryptophan biosensor based on leader (nascent) peptide mechanism with mCherry as control.
DOI: 10.6084/m9.figshare.5539960
title: Supplementary Material for: Efficacy of Antenatal Corticosteroid Treatment on Neurodevelopmental Outcome according to Head Circumference at Birth

description: <b><i>Background:</i></b> There are concerns about the efficacy of antenatal corticosteroid treatment (ACT) in the growth-restricted fetus. <b><i>Objective:</i></b> To evaluate the effect of ACT on neurodevelopmental outcome at 2 years of corrected age according to the <i>z</i> score of birth head circumference (ZS HC) in a large prospective cohort of preterm infants. <b><i>Methods:</i></b> This study was conducted as a population-based, prospective, multicenter study, including 4,965 infants born between 24 and 33 weeks' gestation and whose status regarding ACT and the measurement of head circumference at birth were available. They were evaluated at 2 years of corrected age to assess neurological outcome. Three approaches were considered to estimate the effect of ACT on neurodevelopment: (i) logistic regression with adjustment on propensity score, (ii) weighted logistic regression using the inverse probability of treatment weighting method, and (iii) 1:1 matching of gestational age, ZS HC, and propensity score between treated and nontreated infants. <b><i>Results:</i></b> ACT was documented in 60% of infants. Three groups of infants were considered according to their ZS HC: between -3 and -1 standard deviation (SD), -1 and +1 SD, and +1 and +3 SD, respectively. ACT was associated with a significant improvement of neurodevelopmental outcome only for infants with an ZS HC of between +1 and +3 SD (adjusted OR 1.72; 95% CI 1.06-2.79). Moreover, ORs estimated in the -3 to -1 and +1 to +3 categories were significantly different. <b><i>Conclusion:</i></b> We found beneficial effects of ACT on neurodevelopmental outcomes at 2 years of corrected age only in preterm infants with a ZS HC &gt;1 SD.
DOI: 10.6084/m9.figshare.5539921
title: Supplementary Material for: A Comparison of the Safety and Efficacy of HX575 (Epoetin Alfa Proposed Biosimilar) with Epoetin Alfa in Patients with End-Stage Renal Disease

description: <b><i>Background:</i></b> HX575 (biosimilar epoetin alfa) was approved in Europe in 2007 for the treatment of chronic kidney disease (CKD)-related anemia. This study assessed the clinical equivalence of HX575 with the US-licensed reference epoetin alfa (Epogen®/Procrit®, Amgen/Janssen) following subcutaneous (SC) administration in dialysis patients with CKD-related anemia. <b><i>Methods:</i></b> This randomized, double-blind, parallel-group, multicenter study (NCT01693029) was conducted at 49 US clinical sites. Eligible patients were aged ≥18 years, had end-stage renal disease, were on hemodialysis or peritoneal dialysis for ≥6 months (or ≥12 months in the case of a failed kidney transplant), and were receiving treatment with stable SC doses of epoetin alfa. Eligible patients also had mean hemoglobin (Hb) concentration between 9.0 and 11.5 g/dL during the screening period. The primary endpoint was the mean absolute change in Hb concentration between the screening/baseline period (week-4 to week-1) and the evaluation period (weeks 21 to 28). <b><i>Results:</i></b> Hb values at the end of the evaluation period and the Hb change from baseline to evaluation period were similar between treatment groups. The estimated difference between groups in mean absolute change in Hb concentration was –0.093 g/dL, with 90% CI (–0.23 to 0.04) entirely within the pre-specified equivalence limits (–0.5 to 0.5 g/dL). The safety profile of each medicine was similar and as expected in dialysis patients, and neither method of treatment led to the development of neutralizing, clinically relevant antibodies. <b><i>Conclusions:</i></b> SC HX575 in dialysis patients with renal anemia was therapeutically equivalent to the reference medicine in terms of maintaining stable Hb levels and safety.
DOI: 10.6084/m9.figshare.5539921.v1
title: Supplementary Material for: A Comparison of the Safety and Efficacy of HX575 (Epoetin Alfa Proposed Biosimilar) with Epoetin Alfa in Patients with End-Stage Renal Disease

description: <b><i>Background:</i></b> HX575 (biosimilar epoetin alfa) was approved in Europe in 2007 for the treatment of chronic kidney disease (CKD)-related anemia. This study assessed the clinical equivalence of HX575 with the US-licensed reference epoetin alfa (Epogen®/Procrit®, Amgen/Janssen) following subcutaneous (SC) administration in dialysis patients with CKD-related anemia. <b><i>Methods:</i></b> This randomized, double-blind, parallel-group, multicenter study (NCT01693029) was conducted at 49 US clinical sites. Eligible patients were aged ≥18 years, had end-stage renal disease, were on hemodialysis or peritoneal dialysis for ≥6 months (or ≥12 months in the case of a failed kidney transplant), and were receiving treatment with stable SC doses of epoetin alfa. Eligible patients also had mean hemoglobin (Hb) concentration between 9.0 and 11.5 g/dL during the screening period. The primary endpoint was the mean absolute change in Hb concentration between the screening/baseline period (week-4 to week-1) and the evaluation period (weeks 21 to 28). <b><i>Results:</i></b> Hb values at the end of the evaluation period and the Hb change from baseline to evaluation period were similar between treatment groups. The estimated difference between groups in mean absolute change in Hb concentration was –0.093 g/dL, with 90% CI (–0.23 to 0.04) entirely within the pre-specified equivalence limits (–0.5 to 0.5 g/dL). The safety profile of each medicine was similar and as expected in dialysis patients, and neither method of treatment led to the development of neutralizing, clinically relevant antibodies. <b><i>Conclusions:</i></b> SC HX575 in dialysis patients with renal anemia was therapeutically equivalent to the reference medicine in terms of maintaining stable Hb levels and safety.
DOI: 10.6084/m9.figshare.5539891
title: Supplementary Material for: Acoustic Realization and Inventory Size: Kannada and Malayalam Alveolar/Retroflex Laterals and /ɻ/

description: This study examines formant and spectral moment data for the apical and retroflex lateral sounds /l ɭ/ of the Dravidian languages Kannada and Malayalam, together with the rhotic /ɻ/ of Malayalam. Data are presented for 10 male speakers of each language. We find that the first spectral moment is lower for retroflex laterals than for alveolar laterals, and lower for the rhotic /ɻ/ of Malayalam than for the retroflex lateral in the same language. Differences emerge when the retroflex lateral of Kannada is compared with the same sound in Malayalam. For both languages, F1 is higher and F3 and F4 are lower for the retroflex /ɭ/ than for the alveolar /l/. However, F2 is higher for the retroflex than for the alveolar sound in Kannada, but lower in Malayalam. This difference is also reflected in differences in the second spectral moment between the languages. It is suggested that since proximity of F2 and F3 is known to be a defining feature of the rhotic /ɻ/ in Malayalam, principles of phonetic dispersion apply to keep F2 from becoming too close to F3 for the retroflex lateral /ɭ/ of Malayalam, but not for the same sound in Kannada.
DOI: 10.6084/m9.figshare.5539891.v1
title: Supplementary Material for: Acoustic Realization and Inventory Size: Kannada and Malayalam Alveolar/Retroflex Laterals and /ɻ/

description: This study examines formant and spectral moment data for the apical and retroflex lateral sounds /l ɭ/ of the Dravidian languages Kannada and Malayalam, together with the rhotic /ɻ/ of Malayalam. Data are presented for 10 male speakers of each language. We find that the first spectral moment is lower for retroflex laterals than for alveolar laterals, and lower for the rhotic /ɻ/ of Malayalam than for the retroflex lateral in the same language. Differences emerge when the retroflex lateral of Kannada is compared with the same sound in Malayalam. For both languages, F1 is higher and F3 and F4 are lower for the retroflex /ɭ/ than for the alveolar /l/. However, F2 is higher for the retroflex than for the alveolar sound in Kannada, but lower in Malayalam. This difference is also reflected in differences in the second spectral moment between the languages. It is suggested that since proximity of F2 and F3 is known to be a defining feature of the rhotic /ɻ/ in Malayalam, principles of phonetic dispersion apply to keep F2 from becoming too close to F3 for the retroflex lateral /ɭ/ of Malayalam, but not for the same sound in Kannada.
DOI: 10.6084/m9.figshare.5539882
title: Supplementary Material for: Temporal Associations between Fatigue, Depression, and Apathy after Stroke: Results of the Cognition and Affect after Stroke, a Prospective Evaluation of Risks Study

description: <b><i>Background:</i></b> Poststroke fatigue (PSF) is a form of pathological fatigue that can develop after stroke and has a negative impact on functional outcome. PSF is associated with poststroke depression (PSD), which in turn shows similarities with poststroke apathy (PSA). This study aimed at disentangling the temporal associations between PSF and PSD and between PSF and PSA. <b><i>Methods:</i></b> A total of 250 stroke patients were included, of which 243 completed the Fatigue Severity Scale, Montgomery-Åsberg Depression Rating Scale, and Apathy Evaluation Scale at 3 months poststroke, with follow-up measurements at 6 and 12 months after initial testing. Linear mixed models and linear regressions were performed to evaluate the temporal associations between PSF and PSD, and between PSF and PSA. <b><i>Results:</i></b> PSF was present in 119 patients (49%), of whom 62 patients also had PSD (26%), and 21 patients (9%) also had PSA. At baseline, PSF patients showed higher depression levels, which remained stable at follow-up. PSD patients had higher fatigue levels compared with no-PSD patients at baseline, which remained stable at follow-up. No association between apathy and fatigue was found at baseline and no interaction with time was found. Change in fatigue from baseline to 12-month follow-up was associated with change in depression and with change in apathy. <b><i>Conclusions:</i></b> Bidirectional associations were found between PSF and PSD. In treatment and rehabilitation programs, early focus on the presence of PSD and PSF is important, since these conditions tend to persist. As there are currently more treatment options for PSD, attention for PSD is important and might also have a beneficial effect on PSF.