cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.5281/zenodo.15188115
title: Epigenetic Drug Valproic Acid in vertebrate Aging - Part I: Lifespan analyses

description: Aging is affected by both genetic and epigenetic factors. It has become increasingly clear that rather than being genetically predefined, our lifespan is largely epigenetically determined. Here, we show that exposure to the epigenetic compound valproic acid (VPA) significantly extended both average and maximum lifespan of the vertebrate research model Nothobranchius furzeri. First, to characterize the potentially effective range of VPA and to identify the optimal concentration inducing lifespan extension, we conducted a dose-response analysis in N. furzeri. We identified the concentration of 0.25mM VPA to be most effective in prolonging lifespan. As the incidence of age-related pathologies strikingly increases after having passed midlife, we implemented a late-onset protocol starting VPA administration at week 10 of adult killifish life, roughly corresponding to 90% survivorship of our killifish colony. In this study, VPA treatment (0.5mM and 0.25mM) initiated at middle age produced a highly significant life-extending effect. Specifically, exposure to 0.25mM VPA resulted in an increase  of median and maximum survival by 30% and 28,5%, respectively. With regard to in vivo reaction kinetics indicating epigenetic modifications, administration of the geroprotective compound VPA (0.5mM) via the system water induced histone hyperacetylation within the first 24 hours indicative of a rapidly responding transcriptome. Taken together, our study shows that epigenetic interventions initiated passed midlife hold the potential to slow down the aging process by “rejuvenating” the epigenome thereby extending the disease-free portion of life even at advanced age.
description: Figure 1: Dose-response analysis to valproic acid (VPA)

Figure 2: Lifespan analysis in response to 0.5mM valproic acid (VPA)

Figure 3: Lifespan analysis in response to 0.5mM valproic acid (VPA)

Figure 4: Valproic acid causes dosage dependent hyperacetylation of histones H3 and H4

Figure 5: Valproic acid induces acetylation of histones H3 and H4 in a time-dependent manner
DOI: 10.5281/zenodo.15188116
title: Epigenetic Drug Valproic Acid in vertebrate Aging - Part I: Lifespan analyses

description: Aging is affected by both genetic and epigenetic factors. It has become increasingly clear that rather than being genetically predefined, our lifespan is largely epigenetically determined. Here, we show that exposure to the epigenetic compound valproic acid (VPA) significantly extended both average and maximum lifespan of the vertebrate research model Nothobranchius furzeri. First, to characterize the potentially effective range of VPA and to identify the optimal concentration inducing lifespan extension, we conducted a dose-response analysis in N. furzeri. We identified the concentration of 0.25mM VPA to be most effective in prolonging lifespan. As the incidence of age-related pathologies strikingly increases after having passed midlife, we implemented a late-onset protocol starting VPA administration at week 10 of adult killifish life, roughly corresponding to 90% survivorship of our killifish colony. In this study, VPA treatment (0.5mM and 0.25mM) initiated at middle age produced a highly significant life-extending effect. Specifically, exposure to 0.25mM VPA resulted in an increase  of median and maximum survival by 30% and 28,5%, respectively. With regard to in vivo reaction kinetics indicating epigenetic modifications, administration of the geroprotective compound VPA (0.5mM) via the system water induced histone hyperacetylation within the first 24 hours indicative of a rapidly responding transcriptome. Taken together, our study shows that epigenetic interventions initiated passed midlife hold the potential to slow down the aging process by “rejuvenating” the epigenome thereby extending the disease-free portion of life even at advanced age.
description: Figure 1: Dose-response analysis to valproic acid (VPA)

Figure 2: Lifespan analysis in response to 0.5mM valproic acid (VPA)

Figure 3: Lifespan analysis in response to 0.5mM valproic acid (VPA)

Figure 4: Valproic acid causes dosage dependent hyperacetylation of histones H3 and H4

Figure 5: Valproic acid induces acetylation of histones H3 and H4 in a time-dependent manner
DOI: 10.1285/i30350190n5p457
title: Colophon
DOI: 10.15468/dl.xcfrew
title: Occurrence Download

description: A dataset containing 170 species occurrences available in GBIF matching the query:
{
 "and" : [
 "HasGeospatialIssue is false",
 "HasCoordinate is true",
 "OccurrenceStatus is Present",
 "TaxonKey is Aurelia solida Browne, 1905",
 {
 "or" : [
 "CoordinateUncertaintyInMeters is less than 10000",
 "CoordinateUncertaintyInMeters is null"
 ]
 }
 ]
}

 The dataset includes 170 records from 6 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0016834-250402121839773/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.ka58te
title: Occurrence Download

description: A dataset containing 36515 species occurrences available in GBIF matching the query:
{
 "DatasetKey" : [
 "is Taxon occurrence data for the FungalRoot database"
 ]
}

 The dataset includes 36515 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0016833-250402121839773/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.21227/yfgy-gr30
title: VignaBagnolo

description: The dataset was captured from a vineyard in Bagnolo San Vito, Italy. The dataset comprises sensor readings and high-resolution images collected from 24 March 2024 to 24 December 2024, using one high-resolution camera and a LoRaWAN network of 2 air sensors and 6 soil sensors. The sensors measured air temperature and humidity, soil dielectric permittivity, and soil temperature every 10 minutes. The camera captured one 4-Mpixel RGB image per day.
DOI: 10.15468/dl.rk46pp
title: Occurrence Download

description: A dataset containing 165 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Crudia senegalensis Planch. ex Benth."
 ]
}

 The dataset includes 165 records from 26 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0011083-240314170635999/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.sy4xpm
title: Occurrence Download

description: A dataset containing 111 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Poa aequigluma Tovar"
 ]
}

 The dataset includes 111 records from 16 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0087138-230530130749713/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.xfppe9
title: Occurrence Download

description: A dataset containing 80 species occurrences available in GBIF matching the query:
{
 "SpeciesKey" : [
 "is one of (Portulaca tuberosa Roxb.)"
 ]
}

 The dataset includes 80 records from 21 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0040772-240506114902167/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.5kvqxg
title: Occurrence Download

description: A dataset containing 78 species occurrences available in GBIF matching the query:
{
 "SpeciesKey" : [
 "is one of (Elaeagnus umbellata C.P.Thunb. ex A.Murray)"
 ]
}

 The dataset includes 78 records from 15 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0040769-240506114902167/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.jyukvs
title: Occurrence Download

description: A dataset containing 2305 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Gymnostoma L.A.S.Johnson"
 ]
}

 The dataset includes 2305 records from 39 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0006476-170714134226665/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.8hm55m
title: Occurrence Download

description: A dataset containing 45 species occurrences available in GBIF matching the query:
{
 "SpeciesKey" : [
 "is one of (Larix kaempferi Fortune ex Gordon, 1858)"
 ]
}

 The dataset includes 45 records from 5 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0040771-240506114902167/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.mk7ya3
title: Occurrence Download

description: A dataset containing 95 species occurrences available in GBIF matching the query:
{
 "SpeciesKey" : [
 "is one of (Erodium malacoides (L.) Willd., 1794)"
 ]
}

 The dataset includes 95 records from 24 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0040770-240506114902167/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.uyhr35
title: Occurrence Download

description: A dataset containing 104 species occurrences available in GBIF matching the query:
{
 "SpeciesKey" : [
 "is one of (Salmonopuntia schickendantzii (F.A.C.Weber) Font & M.Köhler)"
 ]
}

 The dataset includes 104 records from 28 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0040777-240506114902167/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.6gt77r
title: Occurrence Download

description: A dataset containing 2203695 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is Guatemala",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present"
 ]
}

 The dataset includes 2203695 records from 469 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0088788-200613084148143/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.sbwqj7
title: Occurrence Download

description: A dataset containing 14 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Crotalaria ballyi Polhill"
 ]
}

 The dataset includes 14 records from 6 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0011094-240314170635999/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.yq9nge
title: Occurrence Download

description: A dataset containing 77 species occurrences available in GBIF matching the query:
{
 "SpeciesKey" : [
 "is one of (Rosa rugosa Dematra)"
 ]
}

 The dataset includes 77 records from 53 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0040775-240506114902167/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.3zjvsg
title: Occurrence Download

description: A dataset containing 1601 species occurrences available in GBIF matching the query:
{
 "or" : [
 "TaxonKey is Ardisia websteri Pipoly",
 "TaxonKey is Mustela felipei Izor & de la Torre, 1978",
 "TaxonKey is Platyrrhinus chocoensis Alberico & Velasco, 1991",
 "TaxonKey is Synallaxis cherriei Gyldenstolpe, 1930",
 "TaxonKey is Doliornis remseni Robbins, G.H.Rosenberg & F.S.Molina, 1994",
 "TaxonKey is Bomarea uncifolia Herb.",
 "TaxonKey is Synallaxis tithys Taczanowski, 1877",
 "TaxonKey is Eriocnemis derbyi (Delattre & Bourcier, 1846)",
 "TaxonKey is Conothraupis speculigera (Gould, 1855)",
 "TaxonKey is Alternanthera areschougii R.E.Fr.",
 "TaxonKey is Acanthosyris annonagustata C.Ulloa & P.M.Jørg."
 ]
}

 The dataset includes 1601 records from 83 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0006476-171002173027117/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.eqhx62
title: Occurrence Download

description: A dataset containing 149 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is United States of America",
 "Geometry POLYGON((-142.00280 34.89340,-88.99720 34.89340,-88.99720 56.10660,-142.00280 56.10660,-142.00280 34.89340))",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 "TaxonKey is Erythronium grandiflorum subsp. grandiflorum"
 ]
}

 The dataset includes 149 records from 9 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0120792-200613084148143/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.txvfku
title: Occurrence Download

description: A dataset containing 66 species occurrences available in GBIF matching the query:
{
 "SpeciesKey" : [
 "is one of (Leonotis nepetifolia Schimp. ex Benth., 1848)"
 ]
}

 The dataset includes 66 records from 26 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0040774-240506114902167/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.q527er
title: Occurrence Download

description: A dataset containing 53 species occurrences available in GBIF matching the query:
{
 "SpeciesKey" : [
 "is one of (Alocasia cucullata Schott)"
 ]
}

 The dataset includes 53 records from 17 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0040782-240506114902167/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.sebb4n
title: Occurrence Download

description: A dataset containing 1051744 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Plegadis falcinellus (Linnaeus, 1766)"
 ]
}

 The dataset includes 1051744 records from 577 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0011082-240314170635999/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.jxr4fz
title: Occurrence Download

description: A dataset containing 58 species occurrences available in GBIF matching the query:
{
 "SpeciesKey" : [
 "is one of (Lonicera stabiana Pasq.)"
 ]
}

 The dataset includes 58 records from 13 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0040784-240506114902167/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.n4gmh6
title: Occurrence Download

description: A dataset containing 51 species occurrences available in GBIF matching the query:
{
 "SpeciesKey" : [
 "is one of (Phalacrachena calva (Ledeb.) Iljin)"
 ]
}

 The dataset includes 51 records from 13 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0040781-240506114902167/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.8u6rmr
title: Occurrence Download

description: A dataset containing 45 species occurrences available in GBIF matching the query:
{
 "SpeciesKey" : [
 "is one of (Centaurea subtilis Bertol.)"
 ]
}

 The dataset includes 45 records from 22 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0040773-240506114902167/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.2rdy8s
title: Occurrence Download

description: A dataset containing 70 species occurrences available in GBIF matching the query:
{
 "SpeciesKey" : [
 "is one of (Nassella manicata (É.Desv.) Barkworth)"
 ]
}

 The dataset includes 70 records from 21 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0040780-240506114902167/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.ljpoc9
title: Occurrence Download

description: A dataset containing 2874 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Dicamptodon tenebrosus (Baird & Girard, 1852)"
 ]
}

 The dataset includes 2874 records from 25 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0006476-171025204727650/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.btazrs
title: Occurrence Download

description: A dataset containing 15 species occurrences available in GBIF matching the query:
{
 "and" : [
 "BasisOfRecord is one of (Specimen, Human Observation)",
 "Continent is South America",
 "Country is Peru",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 "TaxonKey is Myotis atacamensis (Lataste, 1892)",
 "Year 1951-2024"
 ]
}

 The dataset includes 15 records from 4 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0001040-240321170329656/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.y4npf8
title: Occurrence Download

description: A dataset containing 12 species occurrences available in GBIF matching the query:
{
 "and" : [
 {
 "or" : [
 "BasisOfRecord is Observation",
 "BasisOfRecord is Machine Observation",
 "BasisOfRecord is Human Observation",
 "BasisOfRecord is Material sample",
 "BasisOfRecord is Literature Occurrence",
 "BasisOfRecord is Living Specimen"
 ]
 },
 "Country is Mexico",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 "TaxonKey is Oreothlypis celata (Say, 1822)",
 "Year 1980-2020"
 ]
}

 The dataset includes 12 records from 4 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0116224-200613084148143/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.3ua7xh
title: Occurrence Download

description: A dataset containing 112 species occurrences available in GBIF matching the query:
{
 "SpeciesKey" : [
 "is one of (Rosa ×hibernica Templeton)"
 ]
}

 The dataset includes 112 records from 18 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0040783-240506114902167/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.ikutar
title: Occurrence Download

description: A dataset containing 588 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is Mexico",
 "TaxonKey is Holbrookia approximans Baird, 1859"
 ]
}

 The dataset includes 588 records from 19 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0017150-190813142620410/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.z3kgyk
title: Occurrence Download

description: A dataset containing 35 species occurrences available in GBIF matching the query:
{
 "SpeciesKey" : [
 "is one of (Xanthium strumarium Lour., 1790)"
 ]
}

 The dataset includes 35 records from 2 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0040779-240506114902167/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.b86vvk
title: Occurrence Download

description: A dataset containing 262 species occurrences available in GBIF matching the query:
{
 "and" : [
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "TaxonKey is Sapium argutum (Müll.Arg.) Huber"
 ]
}

 The dataset includes 262 records from 33 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0088787-200613084148143/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.05wxue
title: Occurrence Download

description: A dataset containing 6250 species occurrences available in GBIF matching the query:
{
 "DatasetKey" : [
 "is Invasive species - Chinese mitten crab (Eriocheir sinensis) in Flanders, Belgium"
 ]
}

 The dataset includes 6250 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0012679-180412121330197/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.pfkeb8
title: Occurrence Download

description: A dataset containing 48 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Maconellicoccus hirsutus (Green, 1908)"
 ]
}

 The dataset includes 48 records from 5 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0014432-180824113759888/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.qxs4qa
title: Occurrence Download

description: A dataset containing 360 species occurrences available in GBIF matching the query:
{
 "and" : [
 {
 "or" : [
 "BasisOfRecord is Human Observation",
 "BasisOfRecord is Machine Observation",
 "BasisOfRecord is Specimen"
 ]
 },
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 "TaxonKey is Actinonaias pectorosa (Conrad, 1834)"
 ]
}

 The dataset includes 360 records from 9 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0115453-210914110416597/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.vueroq
title: Occurrence Download

description: A dataset containing 125 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Myrcia cerqueiria (Nied.) E.Lucas & Sobral"
 ]
}

 The dataset includes 125 records from 19 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0012679-181003121212138/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.scp2ss
title: Occurrence Download

description: A dataset containing 23 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Geometry POLYGON((-74.51716 -38.20119,-71.30915 -38.20119,-71.30915 -36.91853,-74.51716 -36.91853,-74.51716 -38.20119))",
 "HasCoordinate is true",
 "TaxonKey is Berberidopsis corallina Hook.fil.",
 "HasGeospatialIssue is false"
 ]
}

 The dataset includes 23 records from 4 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0014432-181003121212138/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.