cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.25439402.v1
title: Radiofrequency ablation of hepatocellular carcinoma guided by real-time physics-based ablation simulation: a prospective study

description: To assess the safety and efficacy of radiofrequency ablation (RFA) guidance software that incorporated patient-specific physics-based simulation of each ablation volume. Patients referred for curative ablation of hepatocellular carcinoma (HCC) of 2–5 cm diameter were prospectively enrolled. RFA was performed under general anesthesia. Procedure planning and intraprocedural modifications were guided by computer simulation of each ablation. The segmented target (tumor with 5 mm margin) was registered to and superimposed on subsequent 3D multiplanar images. The applied RF energy was used to calculate a simulated ablation volume which was displayed relative to the electrode and segmented target, to depict any untreated target tissue. After each additional ablation, the software updated the accumulated simulated ablation volume in relation to the target. The primary endpoints were technical efficacy and rate of local tumor progression (LTP). Sixty-eight tumors were ablated during 57 procedures in 52 patients (68.3 ± 9.2 years old, 78.8% male); 15 (26.3%) had multiple lesions and 23 (39.1%) had prior HCC treatment. The mean tumor diameter was 2.73 (±0.64) cm. The intraprocedural simulation directed additional overlapping ablations in 75.9% of tumors. Technical success and efficacy were 100% at 3-month contrast enhanced CT or MRI follow-up after the single treatment session. Cumulative incidence function estimates for 1- and 2-year LTP were 3.9% and 20.2%, respectively. This prospective study found computer-assisted guidance that simulated each ablation was both safe and efficacious. The low rate of LTP was similar to studies that employed stereotactic guidance and ablation confirmation, without requiring a second contrast enhanced study.
DOI: 10.6084/m9.figshare.25529708
title: Deregulated JNK signaling enhances apoptosis during hyperthermia

description: c-Jun N-terminal kinases (JNKs) comprise a subfamily of mitogen-activated protein kinases (MAPKs). The JNK group is known to be activated by a variety of stimuli. However, the molecular mechanism underlying heat-induced JNK activation is largely unknown. The aim of this study was to clarify how JNK activity is stimulated by heat. The expression levels of various MAPK members in HeLa cells, with or without hyperthermia treatment, were evaluated via western blotting. The kinase activity of MAPK members was assessed through <i>in vitro</i> kinase assays. Cell death was assessed in the absence or presence of siRNAs targeting MAPK-related members. Hyperthermia decreased the levels of MAP3Ks, such as ASK1 and MLK3 which are JNK kinase kinase members, but not those of the downstream MAP2K/SEK1 and MAPK/JNK. Despite the reduced or transient phosphorylation of ASK1, MLK3, or SEK1, downstream JNK was phosphorylated in a temperature-dependent manner. <i>In vitro</i> kinase assays demonstrated that heat did not directly stimulate SEK1 or JNK. However, the expression levels of DUSP16, a JNK phosphatase, were decreased upon hyperthermia treatment. DUSP16 knockdown enhanced the heat-induced activation of ASK1–SEK1–JNK pathway and apoptosis. JNK was activated in a temperature-dependent manner despite reduced or transient phosphorylation of the upstream MAP3K and MAP2K. Hyperthermia-induced degradation of DUSP16 may induce activation of the ASK1–SEK1–JNK pathway and subsequent apoptosis.
DOI: 10.6084/m9.figshare.25529708.v1
title: Deregulated JNK signaling enhances apoptosis during hyperthermia

description: c-Jun N-terminal kinases (JNKs) comprise a subfamily of mitogen-activated protein kinases (MAPKs). The JNK group is known to be activated by a variety of stimuli. However, the molecular mechanism underlying heat-induced JNK activation is largely unknown. The aim of this study was to clarify how JNK activity is stimulated by heat. The expression levels of various MAPK members in HeLa cells, with or without hyperthermia treatment, were evaluated via western blotting. The kinase activity of MAPK members was assessed through <i>in vitro</i> kinase assays. Cell death was assessed in the absence or presence of siRNAs targeting MAPK-related members. Hyperthermia decreased the levels of MAP3Ks, such as ASK1 and MLK3 which are JNK kinase kinase members, but not those of the downstream MAP2K/SEK1 and MAPK/JNK. Despite the reduced or transient phosphorylation of ASK1, MLK3, or SEK1, downstream JNK was phosphorylated in a temperature-dependent manner. <i>In vitro</i> kinase assays demonstrated that heat did not directly stimulate SEK1 or JNK. However, the expression levels of DUSP16, a JNK phosphatase, were decreased upon hyperthermia treatment. DUSP16 knockdown enhanced the heat-induced activation of ASK1–SEK1–JNK pathway and apoptosis. JNK was activated in a temperature-dependent manner despite reduced or transient phosphorylation of the upstream MAP3K and MAP2K. Hyperthermia-induced degradation of DUSP16 may induce activation of the ASK1–SEK1–JNK pathway and subsequent apoptosis.
DOI: 10.6084/m9.figshare.25560657
title: Microwave hyperthermia enhances radiosensitization by decreasing DNA repair efficiency and inducing oxidative stress in PC3 prostatic adenocarcinoma cells

description: Radiotherapy (RT) is the primary treatment for prostate cancer (PCa); however, the emergence of castration-resistant prostate cancer (CRPC) often leads to treatment failure and cancer-related deaths. In this study, we aimed to explore the use of microwave hyperthermia (MW-HT) to sensitize PCa to RT and investigate the underlying molecular mechanisms. We developed a dedicated MW-HT heating setup, created an <i>in vitro</i> and <i>in vivo</i> MW-HT + RT treatment model for CRPC. We evaluated PC3 cell proliferation using CCK-8, colony experiments, DAPI staining, comet assay and ROS detection method. We also monitored nude mouse models of PCa during treatment, measured tumor weight, and calculated the tumor inhibition rate. Western blotting was used to detect DNA damage repair protein expression in PC3 cells and transplanted tumors. Compared to control, PC3 cell survival and clone formation rates decreased in RT + MW-HT group, demonstrating significant increase in apoptosis, ROS levels, and DNA damage. Lower tumor volumes and weights were observed in treatment groups. Ki-67 expression level was reduced in all treatment groups, with significant decrease in RT + MW-HT groups. The most significant apoptosis induction was confirmed in RT + MW-HT group by TUNEL staining. Protein expression levels of DNA-PKcs, ATM, ATR, and P53/P21 signaling pathways significantly decreased in RT + MW-HT groups. MW-HT + RT treatment significantly inhibited DNA damage repair by downregulating DNA-PKcs, ATM, ATR, and P53/P21 signaling pathways, leading to increased ROS levels, aggravate DNA damage, apoptosis, and necrosis in PC3 cells, a well-established model of CRPC.
DOI: 10.6084/m9.figshare.25560657.v1
title: Microwave hyperthermia enhances radiosensitization by decreasing DNA repair efficiency and inducing oxidative stress in PC3 prostatic adenocarcinoma cells

description: Radiotherapy (RT) is the primary treatment for prostate cancer (PCa); however, the emergence of castration-resistant prostate cancer (CRPC) often leads to treatment failure and cancer-related deaths. In this study, we aimed to explore the use of microwave hyperthermia (MW-HT) to sensitize PCa to RT and investigate the underlying molecular mechanisms. We developed a dedicated MW-HT heating setup, created an <i>in vitro</i> and <i>in vivo</i> MW-HT + RT treatment model for CRPC. We evaluated PC3 cell proliferation using CCK-8, colony experiments, DAPI staining, comet assay and ROS detection method. We also monitored nude mouse models of PCa during treatment, measured tumor weight, and calculated the tumor inhibition rate. Western blotting was used to detect DNA damage repair protein expression in PC3 cells and transplanted tumors. Compared to control, PC3 cell survival and clone formation rates decreased in RT + MW-HT group, demonstrating significant increase in apoptosis, ROS levels, and DNA damage. Lower tumor volumes and weights were observed in treatment groups. Ki-67 expression level was reduced in all treatment groups, with significant decrease in RT + MW-HT groups. The most significant apoptosis induction was confirmed in RT + MW-HT group by TUNEL staining. Protein expression levels of DNA-PKcs, ATM, ATR, and P53/P21 signaling pathways significantly decreased in RT + MW-HT groups. MW-HT + RT treatment significantly inhibited DNA damage repair by downregulating DNA-PKcs, ATM, ATR, and P53/P21 signaling pathways, leading to increased ROS levels, aggravate DNA damage, apoptosis, and necrosis in PC3 cells, a well-established model of CRPC.
DOI: 10.15468/dl.j3kvng
title: Occurrence Download

description: A dataset containing 227610 species occurrences available in GBIF matching the query:
{
 "and" : [
 "DatasetKey is EOD – eBird Observation Dataset",
 "GadmGid is COL.30.22_2",
 "TaxonKey is Passeriformes",
 "Year 1994-2023"
 ]
}

 The dataset includes 227610 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0055654-241126133413365/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.a34rfs
title: Occurrence Download

description: A dataset containing 318 species occurrences available in GBIF matching the query:
{
 "and" : [
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 "TaxonKey is Prunus phaeosticta (Hance) Maxim.",
 "Year 1979-2000"
 ]
}

 The dataset includes 318 records from 19 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0055663-241126133413365/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.79resd
title: Occurrence Download

description: A dataset containing 1785 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Varanus albigularis Daudin, 1802"
 ]
}

 The dataset includes 1785 records from 50 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0055664-241126133413365/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.17632/pfj8xdz6tx.1
title: The effect of acupressure on vaccine-induced pain in infants: A randomized placebo-controlled trial

description: The dataset includes the evaluation of the effect of acupressure on vaccine-induced pain in children. The study investigated the differences in pain scale scores among infants in the acupressure, placebo, and control groups. The findings indicated that the acupressure group reported reduced pain levels. We collected data via questionnaires. The researcher recorded the infants' heart rates, peripheral oxygen saturation levels, and demographic data. We used the FLACC pain scale to assess the infants' pain levels.
DOI: 10.17632/8mp3tz6s5p.1
title: Analysis of sex-specific DNA methylation differences in saliva by multiplex SNaPshot assay

description: Supplementary material
DOI: 10.17632/vm63bzjrgn.1
title: CNV report

description: If in the tested cell line (compared to the reference) new CNVs greater than 2 Mb and/or LOH greater than 5
Mb are detected the CNV QC test has “failed” regarding the internal QC criteria of CUSCO (Core Unit pluripotent Stem Cells and Organoids an Charité Berlin) . The CNV analysis result suggests that the iPSC line contains neither CNVs &gt; 2 Mb nor regions of LOH &gt; 5 Mb.
DOI: 10.17632/vm63bzjrgn.2
title: CNV report

description: If in the tested cell line (compared to the reference) new CNVs greater than 2 Mb and/or LOH greater than 5
Mb are detected the CNV QC test has “failed” regarding the internal QC criteria of CUSCO (Core Unit pluripotent Stem Cells and Organoids). The CNV analysis result suggests that the iPSC line contains neither CNVs &gt; 2 Mb nor regions of LOH &gt; 5 Mb.
DOI: 10.17632/3cd7dm4fpk.1
title: dataset-The efficacy of Ganduqing Granule in treating populations susceptible to the common cold：A multicenter randomized clinical trial

description: This dataset contains the original data for the paper ‘The efficacy of Ganduqing Granule in treating populations susceptible to the common cold: A multicenter randomized clinical trial’
DOI: 10.15468/dl.sttx4d
title: Occurrence Download

description: A dataset containing 115 species occurrences available in GBIF matching the query:
{
 "and" : [
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 "TaxonKey is Photinia villosa (Thunb.) DC.",
 "Year 1979-2000"
 ]
}

 The dataset includes 115 records from 24 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0055665-241126133413365/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.6084/m9.figshare.28130084.v1
title: Supplementary Material for: Severe hypomagnesemia in a patient treated using carboplatin co-administered with vonoprazan

description: Introduction: We describe a case of severe hypomagnesemia that occurred during treatment with carboplatin (CBDCA) and nanoparticle albumin-bound paclitaxel (nab-PTX) for lung adenocarcinoma when co-administered with vonoprazan. Case Presentation: A man in his 70s was diagnosed with stage IIIA lung adenocarcinoma and received CBDCA and nab-PTX as the first-line treatment. The patient had been taking omeprazole 10 mg once daily (for &gt;3 years) for gastroesophageal reflux disease, but it was switched to lansoprazole 15 mg because of hospital's adopted medication. During the first treatment cycle, his serum creatinine levels increased from 1.0 to 1.5 mg/dL, suggesting CBDCA-associated renal impairment. Because of gastric discomfort on day 15 of the second cycle, lansoprazole was switched to vonoprazan 10 mg once daily. On day 23 of the second cycle, he developed torsades de pointes and was hospitalized; severe hypomagnesemia (0.4 mg/dL) was detected to be causing the symptoms. Discontinuation of vonoprazan and a single intravenous infusion of 60 mEq magnesium sulfate raised serum magnesium levels to 3.7 mg/dL and the arrhythmia disappeared. Mild hypomagnesemia (1.4 mg/dL) reappeared five days later, and an additional intravenous infusion of 20 mEq magnesium sulfate with subsequent oral magnesium oxide (1980 mg/day) resolved the symptoms. CBDCA was discontinued and nab-PTX monotherapy was continued. Vonoprazan was resumed owing to gastric discomfort relapse; however, grade ≥2 hypomagnesemia did not reappear later. Conclusions: This case highlights the risk of severe hypomagnesemia in patients with CBDCA and vonoprazan co-administration; therefore, regular monitoring of serum magnesium levels during the treatment is crucial.
DOI: 10.5281/zenodo.14591445
title: BPM_Water_diffusion

description: Python analysis file and raw data of Water diffusion threw commercial bipolar membrane with different pretreatment. The .txt file is the protocol used to run the Labview software.
DOI: 10.5281/zenodo.14591446
title: BPM_Water_diffusion

description: Python analysis file and raw data of Water diffusion threw commercial bipolar membrane with different pretreatment. The .txt file is the protocol used to run the Labview software.
DOI: 10.6084/m9.figshare.28130090
title: Supplementary Material for: Association between non-invasive liver biomarkers and graft outcomes in kidney transplantation recipients

description: Introduction: Although studies have suggested that metabolic risk profiles are prognostic factors in kidney transplantation recipients (KTRs), the prognostic value of fatty liver, a known surrogate of metabolic risk, in KTRs remain to be elucidated. The objective of this study was to investigate the association between non-invasive liver biomarkers used to assess hepatic steatotic and fibrotic burdens and graft outcomes in KTRs.
Methods: A total of 3,092 patients who underwent deceased or living donor kidney transplantation (KT) between January 2000 and December 2022 were enrolled. Postoperative hepatic fibrotic burdens of KTRs were assessed using the Fibrosis-4 (FIB-4) score and the non-alcoholic fatty liver disease fibrosis score (NFS). The primary outcome was a composite of 50% estimated glomerular filtration rate (eGFR) decline and graft failure. Secondary outcomes included individual outcomes of 50% eGFR decline, graft failure, and acute rejection.
Results: For the primary outcome, during a mean follow-up of 6.0 years, the composite outcome occurred in 519 (16.8%) participants. When stratified into three groups according to FIB-4 score categories, the highest score group (FIB-4≥2.67) had a 2.05-fold (95% confidence interval [CI], 1.44-2.91; P&lt;0.001) higher risk of the composite outcome compared to the lowest score group (FIB-4&lt;1.30). Furthermore, the highest score group showed higher risk of the secondary outcomes, with hazard ratios (95% CI) of 1.75 (1.16-2.66), 1.62 (1.06-2.46), and 2.23 (1.43-3.46) for 50% eGFR decline, acute rejection and graft failure, respectively. Similar findings were observed for NFS.
Conclusions: Higher hepatic fibrotic burdens were associated with unfavorable graft outcomes in KTRs.
DOI: 10.6084/m9.figshare.28130090.v1
title: Supplementary Material for: Association between non-invasive liver biomarkers and graft outcomes in kidney transplantation recipients

description: Introduction: Although studies have suggested that metabolic risk profiles are prognostic factors in kidney transplantation recipients (KTRs), the prognostic value of fatty liver, a known surrogate of metabolic risk, in KTRs remain to be elucidated. The objective of this study was to investigate the association between non-invasive liver biomarkers used to assess hepatic steatotic and fibrotic burdens and graft outcomes in KTRs.
Methods: A total of 3,092 patients who underwent deceased or living donor kidney transplantation (KT) between January 2000 and December 2022 were enrolled. Postoperative hepatic fibrotic burdens of KTRs were assessed using the Fibrosis-4 (FIB-4) score and the non-alcoholic fatty liver disease fibrosis score (NFS). The primary outcome was a composite of 50% estimated glomerular filtration rate (eGFR) decline and graft failure. Secondary outcomes included individual outcomes of 50% eGFR decline, graft failure, and acute rejection.
Results: For the primary outcome, during a mean follow-up of 6.0 years, the composite outcome occurred in 519 (16.8%) participants. When stratified into three groups according to FIB-4 score categories, the highest score group (FIB-4≥2.67) had a 2.05-fold (95% confidence interval [CI], 1.44-2.91; P&lt;0.001) higher risk of the composite outcome compared to the lowest score group (FIB-4&lt;1.30). Furthermore, the highest score group showed higher risk of the secondary outcomes, with hazard ratios (95% CI) of 1.75 (1.16-2.66), 1.62 (1.06-2.46), and 2.23 (1.43-3.46) for 50% eGFR decline, acute rejection and graft failure, respectively. Similar findings were observed for NFS.
Conclusions: Higher hepatic fibrotic burdens were associated with unfavorable graft outcomes in KTRs.
DOI: 10.15468/dl.3mnkv7
title: Occurrence Download

description: A dataset containing 226984 species occurrences available in GBIF matching the query:
{
 "and" : [
 "DatasetKey is EOD – eBird Observation Dataset",
 "GadmGid is TUR.40_1",
 "TaxonKey is Passeriformes",
 "Year 1994-2023"
 ]
}

 The dataset includes 226984 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0055662-241126133413365/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.17632/b5prd4gn2y.1
title: Lidong Date

description: The data used included DEM, land-use data, soil data, and meteorological data. Based on seven periods of Landsat series remote sensing images from 1990, 1995, 2000, 2005, 2010, 2015, and 2020 to extract land-use data combined with DEM and other data, the spatial analysis function of ArcGIS software was used to establish a land-use transfer matrix to extract the area, slope, and other information on sloping farmland in different periods. Methods such as terrain gradient classification, kernel density estimation, exploratory spatial data analysis, and erosion risk identification model were used to analyze the spatio-temporal evolution of sloping farmland in the TGRA and identified erosion risk areas from 1990 to 2020.
DOI: 10.17632/22zvv8w89y.1
title: HRM TQM and Corporate Image

description: The data is generated from Engineers of automobile industry of India collaboratively to study HRM practices and TQM for understanding Corporate Image.
DOI: 10.5281/zenodo.14591409
title: DVS_BPM

description: Analysis python file and raw data of Dynamic Vapor Sorbtion of the commercial bipolar membrane Fumasep FBM with different pretreatments.
DOI: 10.5281/zenodo.14591410
title: DVS_BPM

description: Analysis python file and raw data of Dynamic Vapor Sorbtion of the commercial bipolar membrane Fumasep FBM with different pretreatments.
DOI: 10.15468/dl.7vgbvr
title: Occurrence Download

description: A dataset containing 26260 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Rhizopogon Fr."
 ]
}

 The dataset includes 26260 records from 298 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0055666-241126133413365/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.3zkmey
title: Occurrence Download

description: A dataset containing 60 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Cosmos sulphureus Cav.)",
 "Geometry POLYGON((-10 34,4 34,4 44,-10 44,-10 34))"
 ]
}

 The dataset includes 60 records from 7 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0055667-241126133413365/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.8qjs2e
title: Occurrence Download

description: A dataset containing 36321 species occurrences available in GBIF matching the query:
{
 "and" : [
 "DatasetKey is EOD – eBird Observation Dataset",
 "GadmGid is TUR.41_1",
 "TaxonKey is Passeriformes",
 "Year 1994-2023"
 ]
}

 The dataset includes 36321 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0055668-241126133413365/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.wfaaag
title: Occurrence Download

description: A dataset containing 34442 species occurrences available in GBIF matching the query:
{
 "and" : [
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "TaxonKey is Vipera aspis (Linnaeus, 1758)"
 ]
}

 The dataset includes 34442 records from 813 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0055669-241126133413365/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.5517/ccdc.csd.cc2gl5py
title: CCDC 2281590: Experimental Crystal Structure Determination

description: Related Article: Waseem Arif, Vipin Kumar, Prabhakar Chetti, Ravi Kumar|2024|New J.Chem.|48|18848|doi:10.1039/D4NJ03904A
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.