cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.5024492.v1
title: Quantitative structure–activity relationship study of amide mosquito repellents

description: A quantitative structure–activity relationship (QSAR) study on 43 amide repellents was carried out by the heuristic method in order to reveal the correlations between molecular parameters of these amides and their repellency against <i>Aedes aegypti</i>. Sketches and optimizations of molecular structures were achieved by the Gaussian software package. Generation and screening of molecular parameters were accomplished using CODESSA 2.7.10 software. The leave-one-out method was applied for the model validation. The results showed that a four-descriptor QSAR model with <i>r</i><sup>2</sup> of 0.897 was obtained. The average <i>r</i><sup>2</sup> values of the training set and test set of the QSAR model were 0.901 and 0.863, respectively, which suggested that the stability and predictability of the model were confirmed. Analysis of the implications of the descriptors that constitute the QSAR model indicated that all the descriptors were related to the charge distribution over the molecule and affect the dipole moment of the repellents.
DOI: 10.6084/m9.figshare.5024504.v2
title: Supplementary Material for: The Persistent Müllerian Duct Syndrome: An Update Based Upon a Personal Experience of 157 Cases

description: Male sex differentiation is driven by 2 hormones, testosterone and anti-müllerian hormone (AMH), responsible for the regression of müllerian ducts in male fetuses. Mutations inactivating <i>AMH</i> or its receptor <i>AMHRII</i> lead to the persistent müllerian duct syndrome (PMDS) in otherwise normally virilized 46,XY males. Our objective was to review the clinical, anatomical, and molecular features of PMDS based upon a review of the literature and upon 157 personal cases. Three clinical presentations exist: bilateral cryptorchidism, unilateral cryptorchidism with contralateral hernia, and transverse testicular ectopia. Abnormalities of male excretory ducts are frequent. Testicular malignant degeneration occurs in 33% of adults with the disorder, while cancer of müllerian derivatives is less frequent. Fertility is rare but possible if at least one testis is scrotal and its excretory ducts are intact. Eighty families with 64 different mutations of the <i>AMH</i> gene have been identified, mostly in exons 1, 2, and 5. <i>AMHRII</i> gene mutations representing 58 different alleles have been discovered in 75 families. The most common mutation, a 27-bp deletion in the kinase domain, was found in 30 patients of mostly Northern European origin. In 12% of cases, no mutation of <i>AMH</i> or <i>AMHRII</i> has been detected, suggesting a disruption of other pathways involved in müllerian regression.
DOI: 10.6084/m9.figshare.5024504.v1
title: Supplementary Material for: The Persistent Müllerian Duct Syndrome: An Update Based Upon a Personal Experience of 157 Cases

description: Male sex differentiation is driven by 2 hormones, testosterone and anti-müllerian hormone (AMH), responsible for the regression of müllerian ducts in male fetuses. Mutations inactivating <i>AMH</i> or its receptor <i>AMHRII</i> lead to the persistent müllerian duct syndrome (PMDS) in otherwise normally virilized 46,XY males. Our objective was to review the clinical, anatomical, and molecular features of PMDS based upon a review of the literature and upon 157 personal cases. Three clinical presentations exist: bilateral cryptorchidism, unilateral cryptorchidism with contralateral hernia, and transverse testicular ectopia. Abnormalities of male excretory ducts are frequent. Testicular malignant degeneration occurs in 33% of adults with the disorder, while cancer of müllerian derivatives is less frequent. Fertility is rare but possible if at least one testis is scrotal and its excretory ducts are intact. Eighty families with 64 different mutations of the <i>AMH</i> gene have been identified, mostly in exons 1, 2, and 5. <i>AMHRII</i> gene mutations representing 58 different alleles have been discovered in 75 families. The most common mutation, a 27-bp deletion in the kinase domain, was found in 30 patients of mostly Northern European origin. In 12% of cases, no mutation of <i>AMH</i> or <i>AMHRII</i> has been detected, suggesting a disruption of other pathways involved in müllerian regression.
DOI: 10.6084/m9.figshare.5024477
title: Supplementary Material for: Racial and Ethnic Differences in Mortality Associated with Serum Potassium in a Large Hemodialysis Cohort

description: <b><i>Background:</i></b> Hyperkalemia is observed in chronic kidney disease patients and may be a risk factor for life-threatening arrhythmias and death. Race/ethnicity may be important modifiers of the potassium-mortality relationship in maintenance hemodialysis (MHD) patients given that potassium intake and excretion vary among minorities. <b><i>Methods:</i></b> We examined racial/ethnic differences in baseline serum potassium levels and all-cause and cardiovascular mortality using Cox proportional hazard models and restricted cubic splines in a cohort of 102,241 incident MHD patients. Serum potassium was categorized into 6 groups: ≤3.6, &gt;3.6 to ≤4.0, &gt;4.0 to ≤4.5 (reference), &gt;4.5 to ≤5.0, &gt;5.0 to ≤5.5, and &gt;5.5 mEq/L. Models were adjusted for case-mix and malnutrition-inflammation cachexia syndrome (MICS) covariates. <b><i>Results:</i></b> The cohort was composed of 50% whites, 34% African-Americans, and 16% Hispanics. Hispanics tended to have the highest baseline serum potassium levels (mean ± SD: 4.58 ± 0.55 mEq/L). Patients in our cohort were followed for a median of 1.3 years (interquartile range 0.6-2.5). In our cohort, associations between higher potassium (&gt;5.5 mEq/L) and higher mortality risk were observed in African-American and whites, but not Hispanic patients in models adjusted for case-mix and MICS covariates. While in Hispanics only, lower serum potassium (&lt;3.6 mEq/L) levels were associated with higher mortality risk. Similar trends were observed for cardiovascular mortality. <b><i>Conclusions:</i></b> Higher potassium levels were associated with higher mortality risk in white and African-American MHD patients, whereas lower potassium levels were associated with higher death risk in Hispanics. Further studies are needed to determine the underlying mechanisms for the differential association between potassium and mortality across race/ethnicity.
DOI: 10.6084/m9.figshare.5024468
title: Modelling the influence of sensory dynamics on linear and nonlinear driver steering control

description: A recent review of the literature has indicated that sensory dynamics play an important role in the driver–vehicle steering task, motivating the design of a new driver model incorporating human sensory systems. This paper presents a full derivation of the linear driver model developed in previous work, and extends the model to control a vehicle with nonlinear tyres. Various nonlinear controllers and state estimators are compared with different approximations of the true system dynamics. The model simulation time is found to increase significantly with the complexity of the controller and state estimator. In general the more complex controllers perform best, although with certain vehicle and tyre models linearised controllers perform as well as a full nonlinear optimisation. Various extended Kalman filters give similar results, although the driver's sensory dynamics reduce control performance compared with full state feedback. The new model could be used to design vehicle systems which interact more naturally and safely with a human driver.
DOI: 10.6084/m9.figshare.5024471
title: Supplementary Material for: Association between Chronic Kidney Disease and Risk of Cataract: A Nationwide Retrospective Cohort Study

description: <b><i>Background:</i></b> Previous studies have established a relationship between chronic kidney disease (CKD) and cataract, but the relationship between the severity of renal impairment and risk of cataract is uncertain. This study investigates the relationship between the severity of renal disease and cataract in a nationwide sample from Taiwan. <b><i>Methods:</i></b> The cohort from 1-million National Health Insurance beneficiaries from Taiwan was retrospectively analyzed. All adult beneficiaries were followed from January 1, 2005 until December 31, 2013, to identify patients who underwent cataract surgeries. On the basis of the ambulatory care records, those diagnosed with CKD (ICD-9-CM code: 585) during the follow-up period were enrolled as CKD patients after careful evaluation. Each patient with CKD was age- and gender-matched with 4 individuals who did not have CKD. Cox regression models were applied to compare the hazard of cataract surgery in individuals with and without CKD. Subgroup analysis was used to compare patients with end-stage renal disease (ESRD) with age- and gender-matched non-CKD individuals. ESRD was defined by CKD patients who need regular renal replacement therapy. The same method was applied to evaluate hazard ratios (HRs). <b><i>Results:</i></b> After age and gender matching, there were 11,881 patients in the CKD group and 47,524 in the non-CKD group. After control for possible confounding, the adjusted HR (aHR) of cataract was 1.84 (95% CI 1.73-1.95) for the CKD group. Subgroup analysis of patients with ESRD (<i>n</i> = 3,209) and non-CKD individuals (<i>n</i> = 12,836), with matching done on the basis of age and gender, indicated an aHR of cataract was 2.33 (95% CI 2.10-2.59) for the ESRD group. <b><i>Conclusions:</i></b> This study indicates a relationship between CKD and cataract, and suggests that the risk for cataract increases with the severity of renal impairment.
DOI: 10.6084/m9.figshare.5024465
title: Highly cited documents in Google Scholar by language and year of publication (January 2017)

description: Description of the dataset available in attached PDF.
DOI: 10.6084/m9.figshare.5024471.v1
title: Supplementary Material for: Association between Chronic Kidney Disease and Risk of Cataract: A Nationwide Retrospective Cohort Study

description: <b><i>Background:</i></b> Previous studies have established a relationship between chronic kidney disease (CKD) and cataract, but the relationship between the severity of renal impairment and risk of cataract is uncertain. This study investigates the relationship between the severity of renal disease and cataract in a nationwide sample from Taiwan. <b><i>Methods:</i></b> The cohort from 1-million National Health Insurance beneficiaries from Taiwan was retrospectively analyzed. All adult beneficiaries were followed from January 1, 2005 until December 31, 2013, to identify patients who underwent cataract surgeries. On the basis of the ambulatory care records, those diagnosed with CKD (ICD-9-CM code: 585) during the follow-up period were enrolled as CKD patients after careful evaluation. Each patient with CKD was age- and gender-matched with 4 individuals who did not have CKD. Cox regression models were applied to compare the hazard of cataract surgery in individuals with and without CKD. Subgroup analysis was used to compare patients with end-stage renal disease (ESRD) with age- and gender-matched non-CKD individuals. ESRD was defined by CKD patients who need regular renal replacement therapy. The same method was applied to evaluate hazard ratios (HRs). <b><i>Results:</i></b> After age and gender matching, there were 11,881 patients in the CKD group and 47,524 in the non-CKD group. After control for possible confounding, the adjusted HR (aHR) of cataract was 1.84 (95% CI 1.73-1.95) for the CKD group. Subgroup analysis of patients with ESRD (<i>n</i> = 3,209) and non-CKD individuals (<i>n</i> = 12,836), with matching done on the basis of age and gender, indicated an aHR of cataract was 2.33 (95% CI 2.10-2.59) for the ESRD group. <b><i>Conclusions:</i></b> This study indicates a relationship between CKD and cataract, and suggests that the risk for cataract increases with the severity of renal impairment.
DOI: 10.6084/m9.figshare.5024462
title: Supplementary Material for: Epidemiology of Amyotrophic Lateral Sclerosis in the Republic of Cyprus: A 25-Year Retrospective Study

description: <b><i>Introduction:</i></b> Amyotrophic lateral sclerosis (ALS) is a rare, rapidly progressive neurodegenerative disease. Despite wide variability in the incidence and prevalence of ALS, there is evidence of positive temporal trends and an increase in incidence with age. The aim of this study was to conduct a detailed epidemiological investigation of ALS in Cyprus. <b><i>Methods:</i></b> All registered Cypriot ALS patients in the Republic of Cyprus from January 1985 until December 2014 were included. Socio-demographic information was extracted from patient files. <b><i>Results:</i></b> The study identified 179 ALS patients, of whom 7 had a positive family history. The mean age at onset was 58.6 years and a slight male predominance was observed. Average annual crude incidence was 1.26 cases/100,000 person-years and at the beginning of 2015, prevalence of ALS was 7.9 cases/100,000 population. Both incidence and prevalence displayed an increasing trend, even after age-standardization of incidence rates. <b><i>Conclusions:</i></b> Incidence, prevalence and main socio-demographic characteristics of ALS in Cyprus were similar to those of other European countries, without any geographic clustering of the disease. Additionally, an increased incidence through the years was confirmed. However, observations such as a higher male prevalence and a younger mean age of onset compared to published literature require further investigation.
DOI: 10.6084/m9.figshare.5024465.v1
title: Highly cited documents in Google Scholar by language and year of publication (January 2017)

description: Description of the dataset available in attached PDF.
DOI: 10.6084/m9.figshare.5024468.v2
title: Modelling the influence of sensory dynamics on linear and nonlinear driver steering control

description: A recent review of the literature has indicated that sensory dynamics play an important role in the driver–vehicle steering task, motivating the design of a new driver model incorporating human sensory systems. This paper presents a full derivation of the linear driver model developed in previous work, and extends the model to control a vehicle with nonlinear tyres. Various nonlinear controllers and state estimators are compared with different approximations of the true system dynamics. The model simulation time is found to increase significantly with the complexity of the controller and state estimator. In general the more complex controllers perform best, although with certain vehicle and tyre models linearised controllers perform as well as a full nonlinear optimisation. Various extended Kalman filters give similar results, although the driver's sensory dynamics reduce control performance compared with full state feedback. The new model could be used to design vehicle systems which interact more naturally and safely with a human driver.
DOI: 10.6084/m9.figshare.5024456
title: The tardigrade fauna of Tunisia, with an integrative description of <i>Bryodelphax maculatus</i> sp. nov. (Heterotardigrada: Echiniscidae)

description: The current knowledge of the diversity and distribution of tardigrade species in northern Africa is scarce and far from satisfactory. In this paper we review old and provide new faunistic records for various regions of Tunisia. Among the newly recorded taxa, we found a new heterotardigrade <i>Bryodelphax maculatus</i> sp. nov. The new species belongs to the <i>weglarskae</i> group, characterised by the presence of ventral plates, but differs from its congeners by a different arrangement of ventral plates and by conspicuous groups of cuticular tubercles on the ventral cuticle. The analysis of larval, juvenile and mature instars of the new species revealed, for the first time in heterotardigrades, ontogenetic variability in the development of ventral armature. http://zoobank.org/urn:lsid:zoobank.org:pub:7EA21201-8C74-4BFD-8EAF-A131A78805F0
DOI: 10.6084/m9.figshare.5024468.v1
title: Modelling the influence of sensory dynamics on linear and nonlinear driver steering control

description: A recent review of the literature has indicated that sensory dynamics play an important role in the driver–vehicle steering task, motivating the design of a new driver model incorporating human sensory systems. This paper presents a full derivation of the linear driver model developed in previous work, and extends the model to control a vehicle with nonlinear tyres. Various nonlinear controllers and state estimators are compared with different approximations of the true system dynamics. The model simulation time is found to increase significantly with the complexity of the controller and state estimator. In general the more complex controllers perform best, although with certain vehicle and tyre models linearised controllers perform as well as a full nonlinear optimisation. Various extended Kalman filters give similar results, although the driver's sensory dynamics reduce control performance compared with full state feedback. The new model could be used to design vehicle systems which interact more naturally and safely with a human driver.
DOI: 10.6084/m9.figshare.5024453
title: Development of gene expression assays measuring immune responses in the spotted hyena (<i>Crocuta crocuta</i>)

description: As scavengers, spotted hyenas (<i>Crocuta crocuta</i>) are exposed to a wide array of pathogens but exhibit low mortality rates due to infectious disease. This suggests that this species exhibits a unique and robust immune response to pathogens. However, few tools exist to measure cell-mediated immunity (CMI) in hyenas and we aimed to develop a gene expression assay to quantify antigen-specific responses. Whole blood from five <i>Mycobacterium bovis</i>- sensitised hyenas was incubated in Nil and TB antigen tubes of the QuantiFERON®-TB Gold (QFT) system. Using qPCR, the relative expression stability of the reference genes <i>ACTB</i>, <i>GAPDH</i>, <i>YWHAZ</i> and <i>TBP</i> in these samples was determined as well as the mean fold change in the expression of <i>IFNG</i>, <i>CXCL8</i>, <i>CXCL9</i>, <i>CXCL10</i> and <i>CXCL11</i> in <i>M. bovis</i>-antigen stimulated blood. The expression of <i>YWHAZ</i> and <i>TBP</i> showed greatest stability, and <i>YWHAZ</i> was selected as a reference for further analysis. The expression of <i>CXCL9</i> and <i>CXCL11</i> showed greatest upregulation in antigen-stimulated blood and the assay results for these genes were strongly correlated. The measurement of antigen-induced <i>CXCL9</i> and <i>CXCL11</i> expression, relative to that of <i>YWHAZ</i>, can be used to measure <i>CMI</i> responses to infectious diseases in spotted hyenas.
DOI: 10.6084/m9.figshare.5024450
title: Supplementary Material for: An Insight into the Changes in Skin Texture and Properties following Dietary Intervention with a Nutricosmeceutical Containing a Blend of Collagen Bioactive Peptides and Antioxidants

description: <b><i>Background:</i></b> Skin aging is a multifactorial phenomenon which causes alterations in skin physiological functions and, most visibly, phenotypic changes. In particular, during the aging process, hyaluronic acid, collagen, and elastin fibers undergo structural and functional changes. <b><i>Aims:</i></b> This study aimed to give an insight into the photo-protective benefits and efficacy of an oral liquid nutricosmeceutical containing collagen bioactive peptides and antioxidants to counteract the signs of aging. <b><i>Methods:</i></b> A double-blind, randomized, placebo-controlled clinical trial was conducted by an independent esthetic clinic on 120 healthy volunteer subjects for 90 days. Subjects were divided into 2 groups: 60 subjects consumed 1 bottle (50 mL) of the nutricosmeceutical daily and the other 60 consumed 1 bottle (50 mL) of the placebo. Outcome measures were related to skin elasticity (expressed as Young's elasticity modulus) and skin architecture (histological analysis). In addition, the subjects recruited in this study underwent observational assessments through self-assessment questionnaires. <b><i>Results and Conclusions:</i></b> Overall, we demonstrated a significant increase in skin elasticity (+7.5%), <i>p</i> ≤ 0.001 and an improvement in skin texture after daily oral consumption of the nutricosmeceutical. We also obtained a positive patient feedback through the self-assessment questionnaires. Taken together these results show that this nutricosmeceutical supplement may have photo-protective effects and help improve skin health.
DOI: 10.6084/m9.figshare.5024453.v1
title: Development of gene expression assays measuring immune responses in the spotted hyena (<i>Crocuta crocuta</i>)

description: As scavengers, spotted hyenas (<i>Crocuta crocuta</i>) are exposed to a wide array of pathogens but exhibit low mortality rates due to infectious disease. This suggests that this species exhibits a unique and robust immune response to pathogens. However, few tools exist to measure cell-mediated immunity (CMI) in hyenas and we aimed to develop a gene expression assay to quantify antigen-specific responses. Whole blood from five <i>Mycobacterium bovis</i>- sensitised hyenas was incubated in Nil and TB antigen tubes of the QuantiFERON®-TB Gold (QFT) system. Using qPCR, the relative expression stability of the reference genes <i>ACTB</i>, <i>GAPDH</i>, <i>YWHAZ</i> and <i>TBP</i> in these samples was determined as well as the mean fold change in the expression of <i>IFNG</i>, <i>CXCL8</i>, <i>CXCL9</i>, <i>CXCL10</i> and <i>CXCL11</i> in <i>M. bovis</i>-antigen stimulated blood. The expression of <i>YWHAZ</i> and <i>TBP</i> showed greatest stability, and <i>YWHAZ</i> was selected as a reference for further analysis. The expression of <i>CXCL9</i> and <i>CXCL11</i> showed greatest upregulation in antigen-stimulated blood and the assay results for these genes were strongly correlated. The measurement of antigen-induced <i>CXCL9</i> and <i>CXCL11</i> expression, relative to that of <i>YWHAZ</i>, can be used to measure <i>CMI</i> responses to infectious diseases in spotted hyenas.
DOI: 10.6084/m9.figshare.5024456.v1
title: The tardigrade fauna of Tunisia, with an integrative description of <i>Bryodelphax maculatus</i> sp. nov. (Heterotardigrada: Echiniscidae)

description: The current knowledge of the diversity and distribution of tardigrade species in northern Africa is scarce and far from satisfactory. In this paper we review old and provide new faunistic records for various regions of Tunisia. Among the newly recorded taxa, we found a new heterotardigrade <i>Bryodelphax maculatus</i> sp. nov. The new species belongs to the <i>weglarskae</i> group, characterised by the presence of ventral plates, but differs from its congeners by a different arrangement of ventral plates and by conspicuous groups of cuticular tubercles on the ventral cuticle. The analysis of larval, juvenile and mature instars of the new species revealed, for the first time in heterotardigrades, ontogenetic variability in the development of ventral armature. http://zoobank.org/urn:lsid:zoobank.org:pub:7EA21201-8C74-4BFD-8EAF-A131A78805F0