cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.21639889.v1
title: Knowledge connections for conservation of the Atlantic Goliath Grouper, Epinephelus itajara: records of tropical Brazilian coast

description: Abstract The Atlantic Goliath Grouper (AGG), Epinephelus itajara, the largest Epinephelidae in the Atlantic Ocean, it is classified as critically endangered in Brazil. In the Brazilian northeast, studies focusing on the species are still incipient. Here we study the occurrence, habitat use, and spatial distribution of AGG in Alagoas (Brazil) by combining participatory methods, such as Citizen Science and Local Ecological Knowledge. Living individuals represented 64% (n = 85) of the records, while dead individuals were 36% (n = 47), with 14 records from illegal captures. Juveniles are common in estuaries and shallow natural coastal reefs, while adults are distributed in deeper areas on natural and artificial reefs. The occurrence was significantly higher on Alagoas’ southern coast. The São Francisco River (SFR) estuary stood out with 52 occurrences. We mapped 37 occurrence sites for AGG distributed along the coast, emphasising an artificial reef near SFR that received 12 reports about aggregations. The influence area of the SFR was indicated as a priority for species conservation due to the identification of a nursery and possible aggregations close to its mouth. We highlight the urgency of implementing short and long-term management actions along Alagoas’ coast.
DOI: 10.6084/m9.figshare.21755702
title: Heinrich Gerber’s vision of the tropics, 1850-1860: the scientific and economic thinking of a German polytechnic engineer in the Empire of Brazil

description: Abstract This article analyzes the scientific thinking of the German polytechnic engineer Heinrich August Anton Gerber, who was employed by Minas Gerais province from 1858 to 1867. We explore the cultural and intellectual significance of his activities, particularly the idea of creating a private company within the roadway infrastructure sector and his mediating role in the importation of scientific instruments and books. Gerber also appears to have been part of efforts to send Brazilians to study engineering in Paris. Cultural exchanges between Brazil and Europe are investigated, along with the application of scientific knowledge and his encounters with practical economic and social challenges in the interior of the Empire of Brazil.
DOI: 10.6084/m9.figshare.21755702.v1
title: Heinrich Gerber’s vision of the tropics, 1850-1860: the scientific and economic thinking of a German polytechnic engineer in the Empire of Brazil

description: Abstract This article analyzes the scientific thinking of the German polytechnic engineer Heinrich August Anton Gerber, who was employed by Minas Gerais province from 1858 to 1867. We explore the cultural and intellectual significance of his activities, particularly the idea of creating a private company within the roadway infrastructure sector and his mediating role in the importation of scientific instruments and books. Gerber also appears to have been part of efforts to send Brazilians to study engineering in Paris. Cultural exchanges between Brazil and Europe are investigated, along with the application of scientific knowledge and his encounters with practical economic and social challenges in the interior of the Empire of Brazil.
DOI: 10.5281/zenodo.7461373
title: DAPSI Open Call3-Subgrantees Dataset

description: This file contains the main data from the awarded applicants in the third open call of the NGI-DAPSI Programme funded under the GA 871498.
DOI: 10.5281/zenodo.7461372
title: DAPSI Open Call3-Subgrantees Dataset

description: This file contains the main data from the awarded applicants in the third open call of the NGI-DAPSI Programme funded under the GA 871498.
DOI: 10.6084/m9.figshare.21755705
title: DETERMINATION OF TOTAL AND BIOACCESSIBLE ELEMENTS IN TEMPORARY ADHESIVE TATTOOS USED BY CHILDREN AND ADULTS

description: The presence of bioaccessible potentially-toxic elements in five different brands of temporary tattoos (packaged with bubble gums) aimed at children and three product brands used by young and adult audiences were analyzed in accordance with the Brazilian Organization of Technical Standards (ABNT) and International Organization for Standardization (ISO) for toy’s safety standards. Bioaccessible barium, copper and strontium were found in the concentration range between 1.78-11.1 μg g-1, 0.0364-0.875 μg g-1, 0.155-9.9 μg g-1, respectively. Bioaccessible lead (2.6 ± 0.1 μg g-1 - 4.36 ± 0.06 μg g-1) and boron (2.14 ± 0.07 - 3.54 ± 0.07 μg g-1) were found in two samples whereas chromium (0.403 ± 0.004 μg g-1) in one sample aimed at children. Bioaccessible aluminum was found in six samples, mostly at products used by children. Other elements whose bioaccessibility was evaluated were Mo (&lt; LOD), Cd (&lt; LOD), V (0.148 ± 0.003 μg g-1) and Co (0.003 - 1.756 μg g-1). All samples met the upper limits permitted by the national toy safety standard, however, chromium, lead, cobalt and barium presented higher bioaccessibility levels than the allowed values by cosmetic regulation that controls products applied directly to the skin.
DOI: 10.6084/m9.figshare.21755705.v1
title: DETERMINATION OF TOTAL AND BIOACCESSIBLE ELEMENTS IN TEMPORARY ADHESIVE TATTOOS USED BY CHILDREN AND ADULTS

description: The presence of bioaccessible potentially-toxic elements in five different brands of temporary tattoos (packaged with bubble gums) aimed at children and three product brands used by young and adult audiences were analyzed in accordance with the Brazilian Organization of Technical Standards (ABNT) and International Organization for Standardization (ISO) for toy’s safety standards. Bioaccessible barium, copper and strontium were found in the concentration range between 1.78-11.1 μg g-1, 0.0364-0.875 μg g-1, 0.155-9.9 μg g-1, respectively. Bioaccessible lead (2.6 ± 0.1 μg g-1 - 4.36 ± 0.06 μg g-1) and boron (2.14 ± 0.07 - 3.54 ± 0.07 μg g-1) were found in two samples whereas chromium (0.403 ± 0.004 μg g-1) in one sample aimed at children. Bioaccessible aluminum was found in six samples, mostly at products used by children. Other elements whose bioaccessibility was evaluated were Mo (&lt; LOD), Cd (&lt; LOD), V (0.148 ± 0.003 μg g-1) and Co (0.003 - 1.756 μg g-1). All samples met the upper limits permitted by the national toy safety standard, however, chromium, lead, cobalt and barium presented higher bioaccessibility levels than the allowed values by cosmetic regulation that controls products applied directly to the skin.
DOI: 10.6084/m9.figshare.21755704
title: Coronary Tortuosity as a New Phenotype for Ischemia without Coronary Artery Disease

description: Abstract Background Coronary arteries tend to be more tortuous than other arteries and follow the repeated flexion and relaxation movements that occur during the cardiac cycle. Coronary tortuosity (CorT) leads to changes in coronary flow with a reduction in distal perfusion pressure, which could cause myocardial ischemia. Objective To assess the association between CorT and myocardial ischemia. Methods Between January 2015 and December 2017, 57 patients with angina and nonobstructive coronary artery disease detected by invasive coronary angiography (ICA) were retrospectively enrolled. Angiographic variables were analyzed to assess the presence and degree of tortuosity and correlated with their respective vascular territories on stress myocardial perfusion imaging (MPI). CorT was defined as coronary arteries with three or more bend angles ≤90°, measured during diastole. Statistical significance was determined at the 5% level. Results A total of 17 men and 40 women were enrolled (mean age 58.3 years). CorT was observed in 16 patients (28%) and in 24 of 171 arteries. There was a significant association between CorT and ischemia when analyzed per artery (p&lt;0.0001). The angiographic factor most associated with ischemia was the number of bend angles in an epicardial artery measured at systole (p=0.021). Conclusion This study showed an association of CorT and myocardial ischemia in patients with unobstructed coronary arteries and angina. An increased number of coronary bend angles measured by angiography during systole was related to ischemia.
DOI: 10.6084/m9.figshare.21755704.v1
title: Coronary Tortuosity as a New Phenotype for Ischemia without Coronary Artery Disease

description: Abstract Background Coronary arteries tend to be more tortuous than other arteries and follow the repeated flexion and relaxation movements that occur during the cardiac cycle. Coronary tortuosity (CorT) leads to changes in coronary flow with a reduction in distal perfusion pressure, which could cause myocardial ischemia. Objective To assess the association between CorT and myocardial ischemia. Methods Between January 2015 and December 2017, 57 patients with angina and nonobstructive coronary artery disease detected by invasive coronary angiography (ICA) were retrospectively enrolled. Angiographic variables were analyzed to assess the presence and degree of tortuosity and correlated with their respective vascular territories on stress myocardial perfusion imaging (MPI). CorT was defined as coronary arteries with three or more bend angles ≤90°, measured during diastole. Statistical significance was determined at the 5% level. Results A total of 17 men and 40 women were enrolled (mean age 58.3 years). CorT was observed in 16 patients (28%) and in 24 of 171 arteries. There was a significant association between CorT and ischemia when analyzed per artery (p&lt;0.0001). The angiographic factor most associated with ischemia was the number of bend angles in an epicardial artery measured at systole (p=0.021). Conclusion This study showed an association of CorT and myocardial ischemia in patients with unobstructed coronary arteries and angina. An increased number of coronary bend angles measured by angiography during systole was related to ischemia.
DOI: 10.6084/m9.figshare.21755707
title: Ultrasound reference values for peripheral nerve cross-sectional areas and indices in a sample of healthy individuals in Brazil

description: Abstract Objective: To establish peripheral nerve cross-sectional area (CSA) reference values (absolute values, measures of asymmetry, and measures of focality) for healthy individuals in Brazil. Materials and Methods: Sixty-six healthy volunteers underwent high-resolution ultrasound of the peripheral nerves. We obtained CSA measurements for three peripheral nerves, at specific locations: the median nerve, in the carpal tunnel (MT); the ulnar nerve, at the cubital tunnel site (UT) and at the pre-tunnel site (UPT); and the common fibular nerve, near the fibular head (FH). We calculated the CSA indices between the same sites on different sides (∆CSAs) and between the ulnar nerve tunnel and pre-tunnel sites on the same side (∆TPT). Results: A total of 132 neural sites were analyzed, and the following CSA values (mean ± SD, median) were obtained: MT (6.3 ± 1.9 mm2, 6.0 mm2); UT (6.2 ± 1.6 mm2, 6.1 mm2); UPT (5.6 ± 1.7 mm2, 5.4 mm2); and FH (10.0 ± 3.7 mm2, 9.9 mm2). The ∆CSA values (mean ± SD, median) were as follows: MT (0.85 ± 0.7 mm2, 0.95); UT (0.81 ± 0.62 mm2, 0.95); UPT (0.61 ± 0.51 mm2, 0.5); and FH (1.0 ± 0.77 mm2, 1.0). The ∆TPT (mean ± SD, median) was (1.0 ± 0.8 mm2, 1.0). Conclusion: Among individuals in Brazil, peripheral nerve CSA values tend to be higher among males and to increase with aging. However, the same does not appear to hold true for the ∆CSA or the ∆TPT, the exception being the difference between the right and left UT. Differences in CSA values greater than 2.5 mm2 between sides or between sites along the same nerve can indicate asymmetry or focal thickening in neuropathy, respectively.
DOI: 10.6084/m9.figshare.21755707.v1
title: Ultrasound reference values for peripheral nerve cross-sectional areas and indices in a sample of healthy individuals in Brazil

description: Abstract Objective: To establish peripheral nerve cross-sectional area (CSA) reference values (absolute values, measures of asymmetry, and measures of focality) for healthy individuals in Brazil. Materials and Methods: Sixty-six healthy volunteers underwent high-resolution ultrasound of the peripheral nerves. We obtained CSA measurements for three peripheral nerves, at specific locations: the median nerve, in the carpal tunnel (MT); the ulnar nerve, at the cubital tunnel site (UT) and at the pre-tunnel site (UPT); and the common fibular nerve, near the fibular head (FH). We calculated the CSA indices between the same sites on different sides (∆CSAs) and between the ulnar nerve tunnel and pre-tunnel sites on the same side (∆TPT). Results: A total of 132 neural sites were analyzed, and the following CSA values (mean ± SD, median) were obtained: MT (6.3 ± 1.9 mm2, 6.0 mm2); UT (6.2 ± 1.6 mm2, 6.1 mm2); UPT (5.6 ± 1.7 mm2, 5.4 mm2); and FH (10.0 ± 3.7 mm2, 9.9 mm2). The ∆CSA values (mean ± SD, median) were as follows: MT (0.85 ± 0.7 mm2, 0.95); UT (0.81 ± 0.62 mm2, 0.95); UPT (0.61 ± 0.51 mm2, 0.5); and FH (1.0 ± 0.77 mm2, 1.0). The ∆TPT (mean ± SD, median) was (1.0 ± 0.8 mm2, 1.0). Conclusion: Among individuals in Brazil, peripheral nerve CSA values tend to be higher among males and to increase with aging. However, the same does not appear to hold true for the ∆CSA or the ∆TPT, the exception being the difference between the right and left UT. Differences in CSA values greater than 2.5 mm2 between sides or between sites along the same nerve can indicate asymmetry or focal thickening in neuropathy, respectively.
DOI: 10.6084/m9.figshare.21755708
title: Computed tomography angiography in the planning of transcatheter aortic valve replacement: a step-by-step approach

description: Abstract Aortic valve stenosis is the most common acquired valvular heart disease. Transcatheter aortic valve implantation, also known as transcatheter aortic valve replacement (TAVR), is an important treatment option for symptomatic aortic stenosis in patients at any level of surgical risk. The role of computed tomography angiography (CTA) has expanded considerably in recent years, and it has now become the imaging method of choice for the planning of TAVR. Therefore, radiologists should understand the main aspects of this imaging modality, including the appropriate technique and protocol to acquire reliable CTA images and to create a useful radiology report. The aim of this study was to review the most important aspects of CTA for TAVR planning.
DOI: 10.6084/m9.figshare.21755708.v1
title: Computed tomography angiography in the planning of transcatheter aortic valve replacement: a step-by-step approach

description: Abstract Aortic valve stenosis is the most common acquired valvular heart disease. Transcatheter aortic valve implantation, also known as transcatheter aortic valve replacement (TAVR), is an important treatment option for symptomatic aortic stenosis in patients at any level of surgical risk. The role of computed tomography angiography (CTA) has expanded considerably in recent years, and it has now become the imaging method of choice for the planning of TAVR. Therefore, radiologists should understand the main aspects of this imaging modality, including the appropriate technique and protocol to acquire reliable CTA images and to create a useful radiology report. The aim of this study was to review the most important aspects of CTA for TAVR planning.
DOI: 10.6084/m9.figshare.21755710
title: ASSESSMENT OF α-AMYLASE INHIBITION ACTIVITY BY AN OPTIMIZED AND VALIDATED IN VITRO MICROSCALE METHOD

description: Metabolic disorders, including hyperglycemia, characterize type-2 diabetes. One of the treatment methods used for postprandial hyperglycemia includes using potential therapeutic agents to inhibit α-amylase activity. This study utilized fractional design and the simplex method to optimize in vitro microscale assay inhibition conditions using Miller’s reaction. In addition, the effect of substrate concentration on enzyme activity was analyzed. Enzyme concentration of 0.15 U mL-1 and pre- and post-incubation times of 7.2 and 5.5 min, respectively, in water bath (15.6 min) equipment, were set up for optimized condition for the enzyme activity. Analytical validation was performed based on different international guidelines. Km was found to be 0.38 mg mL-1. Linearity was obtained at the acarbose concentration of 1.5 µg mL-1 and 5 µg mL-1. The IC50 for the positive control was found to be 0.6 µg mL-1. The relative standard deviation and Z value were found to be &lt;4% and &gt;0.93, respectively. Additionally, the optimized assay was applied to extracts from five different plants. Two plant extracts (Zanthoxylum fagara and Chrysactinia mexicana) inhibited α-amylase activity. The optimized and validated method was accurate, precise, and linear.
DOI: 10.6084/m9.figshare.21755710.v1
title: ASSESSMENT OF α-AMYLASE INHIBITION ACTIVITY BY AN OPTIMIZED AND VALIDATED IN VITRO MICROSCALE METHOD

description: Metabolic disorders, including hyperglycemia, characterize type-2 diabetes. One of the treatment methods used for postprandial hyperglycemia includes using potential therapeutic agents to inhibit α-amylase activity. This study utilized fractional design and the simplex method to optimize in vitro microscale assay inhibition conditions using Miller’s reaction. In addition, the effect of substrate concentration on enzyme activity was analyzed. Enzyme concentration of 0.15 U mL-1 and pre- and post-incubation times of 7.2 and 5.5 min, respectively, in water bath (15.6 min) equipment, were set up for optimized condition for the enzyme activity. Analytical validation was performed based on different international guidelines. Km was found to be 0.38 mg mL-1. Linearity was obtained at the acarbose concentration of 1.5 µg mL-1 and 5 µg mL-1. The IC50 for the positive control was found to be 0.6 µg mL-1. The relative standard deviation and Z value were found to be &lt;4% and &gt;0.93, respectively. Additionally, the optimized assay was applied to extracts from five different plants. Two plant extracts (Zanthoxylum fagara and Chrysactinia mexicana) inhibited α-amylase activity. The optimized and validated method was accurate, precise, and linear.
DOI: 10.6084/m9.figshare.21755711
title: Development finance innovations and conditioning factors: The case of the Brazilian Development Bank and sustainable industries

description: ABSTRACT This article analyses the policy capacity of the Brazilian Development Bank, BNDES, to develop and implement finance innovations to foster the local wind industry and their suppliers in the 2010s and which exogenous and endogenous factors conditioned its actions and the related outcomes. It demonstrates that technology, market, and policy drivers constituted exogenous windows of opportunities while, from an endogenous perspective, BNDES timely mobilised internal competencies to implement successive finance innovations resulting in a significant development of such sustainable industry. It is hoped that this article may be a source of inspiration for those engaged in researching and promoting policy innovations.
DOI: 10.6084/m9.figshare.21755711.v1
title: Development finance innovations and conditioning factors: The case of the Brazilian Development Bank and sustainable industries

description: ABSTRACT This article analyses the policy capacity of the Brazilian Development Bank, BNDES, to develop and implement finance innovations to foster the local wind industry and their suppliers in the 2010s and which exogenous and endogenous factors conditioned its actions and the related outcomes. It demonstrates that technology, market, and policy drivers constituted exogenous windows of opportunities while, from an endogenous perspective, BNDES timely mobilised internal competencies to implement successive finance innovations resulting in a significant development of such sustainable industry. It is hoped that this article may be a source of inspiration for those engaged in researching and promoting policy innovations.
DOI: 10.6084/m9.figshare.21755713
title: MOLECULAR BIOMARKERS OF HUMAN DISEASE: FUNDAMENTAL CONCEPTS, RESEARCH MODELS AND CLINICAL APPLICATIONS

description: Molecular biomarkers correspond to all endogenous or exogenous biomolecules, whose presence or alteration in metabolic pathways indicate the response of a biological system to a disturbance caused by internal or external factors. The search for biomarkers has allowed deepening the knowledge of complex pathophysiological mechanisms of diseases, interactions with potential drugs, and the improvement of diagnostic and therapeutic tests, establishing itself as a central point in personalized medicine. In addition, the development of the omics sciences has fostered an increasing exploration in this field of research. This review presents essential and relevant concepts in biomarker research, explores the various definitions and classifications of biomarkers according to their purpose, the critical aspects to be considered in experimental design, the primary employed study models (in vivo, in vitro, and in silico) and the factors that have hindered their ultimate implementation. Finally, important, and current clinical and pharmacological research areas in which biomarker research play a central role are presented.
DOI: 10.6084/m9.figshare.21755713.v1
title: MOLECULAR BIOMARKERS OF HUMAN DISEASE: FUNDAMENTAL CONCEPTS, RESEARCH MODELS AND CLINICAL APPLICATIONS

description: Molecular biomarkers correspond to all endogenous or exogenous biomolecules, whose presence or alteration in metabolic pathways indicate the response of a biological system to a disturbance caused by internal or external factors. The search for biomarkers has allowed deepening the knowledge of complex pathophysiological mechanisms of diseases, interactions with potential drugs, and the improvement of diagnostic and therapeutic tests, establishing itself as a central point in personalized medicine. In addition, the development of the omics sciences has fostered an increasing exploration in this field of research. This review presents essential and relevant concepts in biomarker research, explores the various definitions and classifications of biomarkers according to their purpose, the critical aspects to be considered in experimental design, the primary employed study models (in vivo, in vitro, and in silico) and the factors that have hindered their ultimate implementation. Finally, important, and current clinical and pharmacological research areas in which biomarker research play a central role are presented.
DOI: 10.6084/m9.figshare.21755714
title: EVALUATION OF POTENTIALLY TOXIC METALS IN LEACHES FROM SOLID WASTE DEPOSITION AREA IN BELÉM-PARÁ

description: The formation of solid waste is a global challenge regarding environmental preservation. Due to the lifestyle of modern society, which aims to improve practicality, new products are constantly being released in the market and increasing the formation of waste. The decomposition of waste from various origins produces a dark liquid named leachate, which presents high rates of organic and inorganic compounds. The objective of this study was to assess the concentration of potentially toxic metals in the leachate collected from the Aurá dump. The concentrations of Cd, Cu, Cr, Mn, Ni, Pb, and Zn were evaluated in leachate samples collected in a period of a year, covering two typical seasonal periods of the Amazon region with more and less rainfall. The leachate samples collected in the Aurá dump were determined in the Toxicology Laboratory of Instituto Evandro Chagas (IEC), by means of Plasma/Inductively Coupled Optical Emission Spectrometry (ICP-OES). The Cr, Mn, and Pb metals analyzed in the slurry samples are in a concentration above the maximum limits specified by CONAMA Resolution No. 430/2011, causing significant environmental concerns.