cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.30662669
title: Supplementary Material for: Weighted burden analysis of rare genetic variants identifies novel genes with effects on BMI

description: A previous study of 200,000 exome-sequenced UK Biobank participants investigating the association between rare coding variants and BMI had implicated two genes, MC4R and PCSK1, at exome-wide significance. In addition, a further 66 genes were significant with an uncorrected p value of &lt;0.001. Exome sequence data has become available for a further 270,000 participants and weighted burden analyses to test for association with BMI were carried out in this sample for all these 68 genes highlighted by the previous study. Three novel genes, in addition to MC4R and PCSK1, were significant after correction for multiple testing: PTOV1, GALNT9 and ATP8B2. All five genes were exome-wide significant in the whole sample of 470,000 participants. Rare coding variants impairing gene function were associated with reduced BMI for ATP8B2 but increased BMI for the other genes and for all genes loss of function variants had larger effect sizes than nonsynonymous variants. The biological mechanisms whereby the novel genes might affect BMI are not clear, although impairment of ATP8B2 might possibly have an effect on insulin secretion. Functional studies might throw further light on how these genes are involved in regulation of body weight. Collectively, the identified variants are very rare and do not make a major contribution to variation in BMI in the population.
This research has been conducted using the UK Biobank Resource.
DOI: 10.6084/m9.figshare.30662669.v1
title: Supplementary Material for: Weighted burden analysis of rare genetic variants identifies novel genes with effects on BMI

description: A previous study of 200,000 exome-sequenced UK Biobank participants investigating the association between rare coding variants and BMI had implicated two genes, MC4R and PCSK1, at exome-wide significance. In addition, a further 66 genes were significant with an uncorrected p value of &lt;0.001. Exome sequence data has become available for a further 270,000 participants and weighted burden analyses to test for association with BMI were carried out in this sample for all these 68 genes highlighted by the previous study. Three novel genes, in addition to MC4R and PCSK1, were significant after correction for multiple testing: PTOV1, GALNT9 and ATP8B2. All five genes were exome-wide significant in the whole sample of 470,000 participants. Rare coding variants impairing gene function were associated with reduced BMI for ATP8B2 but increased BMI for the other genes and for all genes loss of function variants had larger effect sizes than nonsynonymous variants. The biological mechanisms whereby the novel genes might affect BMI are not clear, although impairment of ATP8B2 might possibly have an effect on insulin secretion. Functional studies might throw further light on how these genes are involved in regulation of body weight. Collectively, the identified variants are very rare and do not make a major contribution to variation in BMI in the population.
This research has been conducted using the UK Biobank Resource.
DOI: 10.5683/sp3/yhkerp
title: Annual Retail Store Data, 2000 [Canada] [Excel Files]
title: ARSD 2000
title: Données annuelles sur le commerce de détail, 2000 [Canada] [Excel Files]

description: The annual Retail store data CD-ROM is an easy-to-use tool for quickly discovering retail trade patterns and trends. The current product presents results from the 1999 and 2000 Annual Retail Store and Annual Retail Chain surveys. This product contains numerous cross-classified data tables using the North American Industrial Classification system (NAICS).The data tables provide access to a wide range of financial variables, such as revenues, expenses,inventory, sales per square footage (chain stores only) and the number of stores. Most data tables contain detailed information on industry (as low as 5-digit NAICS codes), geography (Canada, provinces and territories) and store type (chains, independents, franchises). The electronic product also contains survey metadata, questionnaires, information on industry codes and definitions, and the list of retail chain store respondents. &lt;p&gt;For current Annual Retail Trade Survey data refer to &lt;a href="https://www150.statcan.gc.ca/n1/en/surveys/2447" target="_blank"&gt;Statistics Canada&lt;/a&gt;&lt;/p&gt; &lt;p&gt;&lt;a href="http://odesi.scholarsportal.info/documentation/FINBUS/ARSD/2000/DOCS/arsd00-tables.html" target="_blank"&gt;Access data here&lt;/a&gt;&lt;/p&gt;
description: Migration from Nesstar
description: Annual Retail Store Data
description: Notes: The current product presents results from the 1999 and 2000 Annual Retail Store and Annual Retail Chain surveys.;
DOI: 10.6084/m9.figshare.30662672
title: Supplementary Material for: Efficacy and Safety of Endovascular Thrombectomy in Acute Ischemic Stroke Patients with ASPECTS ≤2: A Systematic Review and Meta-Analysis

description: Background: Acute ischemic stroke (AIS) affects approximately 11.9 million people annually, with large vessel occlusion (LVO) accounting for 10–20% of cases. While endovascular thrombectomy (EVT) is established for AIS with LVO, recent trials have expanded treatment to patients with Alberta Stroke Program Early CT Score (ASPECTS) 3–5. However, the efficacy and safety of EVT in patients with ASPECTS ≤2, representing extremely large infarcts with poor prognoses, remain uncertain due to limited evidence. This study evaluates EVT outcomes in this high-risk population.
Methods: PubMed, Embase, and Web of Science were searched (January 1, 2010–September 20, 2024) for studies comparing EVT plus best medical treatment (BMT) versus BMT alone in AIS patients with ASPECTS ≤2. Outcomes included favorable functional outcome (FFO, mRS 0–2), moderate functional outcome (MFO, mRS 0–3), modified Rankin Scale (mRS) shift, symptomatic intracranial hemorrhage (sICH), any intracranial hemorrhage (ICH), and 90-day mortality. Unadjusted odds ratios (ORs) and risk differences (RDs) with 95% confidence intervals (CIs) were calculated using a random-effects model. Heterogeneity was assessed with the I² statistic.
Results: Seven studies involving 718 patients (305 EVT, 413 BMT) were included. EVT significantly improved FFO (11.8% vs. 1.6%; OR 5.39, 95% CI 2.06–14.13, P=0.0002), MFO (24.2% vs. 11.5%; OR 2.50, 95% CI 1.53–4.09, P=0.0003), and mRS shift (OR 1.64, 95% CI 1.30–2.06, P&lt;0.001). However, EVT increased sICH (16.5% vs. 2.4%; OR 5.30, 95% CI 1.03–27.39, P&lt;0.001) and any ICH (40.7% vs. 14.9%; OR 3.91, 95% CI 2.24–6.83, P&lt;0.001). No significant difference in 90-day mortality was observed (45.5% vs. 50.8%; OR 0.72, 95% CI 0.34–1.53, P=0.40), though EVT showed a trend toward reduced mortality.
Conclusion: EVT significantly improves functional outcomes in AIS patients with ASPECTS ≤2; however, the absolute benefits remain modest, given the poor prognosis associated with large infarcts. While EVT increases hemorrhagic complications, it does not increase mortality and may provide meaningful benefits for carefully selected patients. Further large-scale trials are needed to refine EVT guidelines.
DOI: 10.5683/sp3/ft25hr
title: Aboriginal Peoples Survey, 2006 [Canada]: Children and Youth
title: Children and Youth
title: APS2006: Children and Youth
title: Enquête auprès des peuples autochtones de 2006: (enfants et jeunes)

description: &lt;p&gt;The Aboriginal Peoples Survey provides data on the social and economic conditions of First Nations people living off reserve, Métis and Inuit, aged 6 years and older.&lt;/p&gt;
description: Migration from Nesstar
description: Aboriginal Peoples Survey
description: Notes: The PUMF for Aboriginal children and youth contains 13,238 records. Each record represents one respondent and contains 222 variables.;
DOI: 10.5683/sp3/q3m8c2
title: Access and Support to Education and Training Survey, 2008 [Canada]
title: ASETS, 2008

description: The ASETS brings together three previously-conducted surveys that addressed issues relating to antecedents and determinants to access to postsecondary education, the role of student loans and savings in the financing of postsecondary education and participation in adult education and training. The ASETS replaces the Survey of Approaches to Educational Planning (SAEP), the Post-secondary Education Participation Survey (PEPS) and the Adult Education and Training Survey (AETS), which were last conducted in 2002 and 2003. Bringing together the three surveys realizes economies of scale in the management, development, implementation and dissemination of the survey.
description: Migration from Nesstar
description: Access and Support to Education and Training Survey
description: Notes: The ASETS survey population does not include individuals without telephones or with cellular phones only. As well, it does not include individuals whose current telephone number belonged to households whose members were all aged 65 and over according to the Census. Lastly, the frame does not include households whose telephone number is missing from both the 2006 Census telephone list and from the administration files. Frame coverage is discussed further in Section 8.2.1.;
DOI: 10.6084/m9.figshare.30662672.v1
title: Supplementary Material for: Efficacy and Safety of Endovascular Thrombectomy in Acute Ischemic Stroke Patients with ASPECTS ≤2: A Systematic Review and Meta-Analysis

description: Background: Acute ischemic stroke (AIS) affects approximately 11.9 million people annually, with large vessel occlusion (LVO) accounting for 10–20% of cases. While endovascular thrombectomy (EVT) is established for AIS with LVO, recent trials have expanded treatment to patients with Alberta Stroke Program Early CT Score (ASPECTS) 3–5. However, the efficacy and safety of EVT in patients with ASPECTS ≤2, representing extremely large infarcts with poor prognoses, remain uncertain due to limited evidence. This study evaluates EVT outcomes in this high-risk population.
Methods: PubMed, Embase, and Web of Science were searched (January 1, 2010–September 20, 2024) for studies comparing EVT plus best medical treatment (BMT) versus BMT alone in AIS patients with ASPECTS ≤2. Outcomes included favorable functional outcome (FFO, mRS 0–2), moderate functional outcome (MFO, mRS 0–3), modified Rankin Scale (mRS) shift, symptomatic intracranial hemorrhage (sICH), any intracranial hemorrhage (ICH), and 90-day mortality. Unadjusted odds ratios (ORs) and risk differences (RDs) with 95% confidence intervals (CIs) were calculated using a random-effects model. Heterogeneity was assessed with the I² statistic.
Results: Seven studies involving 718 patients (305 EVT, 413 BMT) were included. EVT significantly improved FFO (11.8% vs. 1.6%; OR 5.39, 95% CI 2.06–14.13, P=0.0002), MFO (24.2% vs. 11.5%; OR 2.50, 95% CI 1.53–4.09, P=0.0003), and mRS shift (OR 1.64, 95% CI 1.30–2.06, P&lt;0.001). However, EVT increased sICH (16.5% vs. 2.4%; OR 5.30, 95% CI 1.03–27.39, P&lt;0.001) and any ICH (40.7% vs. 14.9%; OR 3.91, 95% CI 2.24–6.83, P&lt;0.001). No significant difference in 90-day mortality was observed (45.5% vs. 50.8%; OR 0.72, 95% CI 0.34–1.53, P=0.40), though EVT showed a trend toward reduced mortality.
Conclusion: EVT significantly improves functional outcomes in AIS patients with ASPECTS ≤2; however, the absolute benefits remain modest, given the poor prognosis associated with large infarcts. While EVT increases hemorrhagic complications, it does not increase mortality and may provide meaningful benefits for carefully selected patients. Further large-scale trials are needed to refine EVT guidelines.
DOI: 10.6084/m9.figshare.30662675
title: Supplementary Material for: Comparison of two oral iron formulations for iron deficiency and iron deficiency anemia in Inflammatory Bowel Disease: a prospective study

description: Introduction: The use of oral iron in iron deficiency (ID) and ID anemia (IDA) in inflammatory bowel disease (IBD) is controversial. Its lower cost and ease of administration must be weighed against side effects and efficacy. The aim of this study was to compare the efficacy and tolerability of two oral iron formulations (Sucrosomial® iron (SI) and ferric hydroxide-polymaltose complex (FHPC) for correcting ID and IDA in IBD. As a secondary objective, we aimed to assess the impact of oral iron on correcting ID, IDA, and disability in IBD.
Methods: This was a prospective, observational, bicentric cohort study. We included patients with IBD diagnosed with ID or IDA between November 2022 and November 2023. Physicians were pre-assigned by the investigators to prescribe SI or FHPC. The primary outcome was the efficacy of treatment with oral iron (Hb increase ≥2 g/dL and/or normalization of Hb levels in patients with IDA or correction of iron parameters in patients with ID alone) by week 12. The secondary outcomes were tolerability and the impact of oral iron on the quality of life and disability (IBD-Disk).
Results: Fifty-six patients were included in this study (FHPC group, 33; SI group, 23). A total of 47 patients had ID alone and 9 had IDA. There was no difference in the efficacy between the two formulations. After 12 weeks, 22% of the patients had an increase in Hb ≥ 2 g/dL and/or normalization of Hb levels or iron parameters. There was an improvement in serum iron (53.5 [45] vs. 64.5 [73]; p=0.017), transferrin saturation index (17.0 [10] vs. 26.0 [13]; p&lt;0.001), and Hb levels (in patients with IDA) (11.9 ± 0.9 versus 12.5 ± 1.2; p=0.041). The IBD-disk scores improved (p=0.004) after treatment, and this improvement correlated with increased serum iron (rs=-0.43; p=0.010) and Hb (rs=-0.50; p=0.002) levels. Twelve (21.4%) patients had side effects (8.7% in the SI group vs. 30.3% in the FHPC group (p=0.006)), leading to iron discontinuation in 5 (4/1: FHPC group/SI group).
Discussion: Both iron formulations had similar efficacy. There were fewer side effects in the SI group. Oral iron replacement improved Hb and iron levels after 12 weeks of treatment, and these changes correlated with improvement in disability.
DOI: 10.6084/m9.figshare.30662675.v1
title: Supplementary Material for: Comparison of two oral iron formulations for iron deficiency and iron deficiency anemia in Inflammatory Bowel Disease: a prospective study

description: Introduction: The use of oral iron in iron deficiency (ID) and ID anemia (IDA) in inflammatory bowel disease (IBD) is controversial. Its lower cost and ease of administration must be weighed against side effects and efficacy. The aim of this study was to compare the efficacy and tolerability of two oral iron formulations (Sucrosomial® iron (SI) and ferric hydroxide-polymaltose complex (FHPC) for correcting ID and IDA in IBD. As a secondary objective, we aimed to assess the impact of oral iron on correcting ID, IDA, and disability in IBD.
Methods: This was a prospective, observational, bicentric cohort study. We included patients with IBD diagnosed with ID or IDA between November 2022 and November 2023. Physicians were pre-assigned by the investigators to prescribe SI or FHPC. The primary outcome was the efficacy of treatment with oral iron (Hb increase ≥2 g/dL and/or normalization of Hb levels in patients with IDA or correction of iron parameters in patients with ID alone) by week 12. The secondary outcomes were tolerability and the impact of oral iron on the quality of life and disability (IBD-Disk).
Results: Fifty-six patients were included in this study (FHPC group, 33; SI group, 23). A total of 47 patients had ID alone and 9 had IDA. There was no difference in the efficacy between the two formulations. After 12 weeks, 22% of the patients had an increase in Hb ≥ 2 g/dL and/or normalization of Hb levels or iron parameters. There was an improvement in serum iron (53.5 [45] vs. 64.5 [73]; p=0.017), transferrin saturation index (17.0 [10] vs. 26.0 [13]; p&lt;0.001), and Hb levels (in patients with IDA) (11.9 ± 0.9 versus 12.5 ± 1.2; p=0.041). The IBD-disk scores improved (p=0.004) after treatment, and this improvement correlated with increased serum iron (rs=-0.43; p=0.010) and Hb (rs=-0.50; p=0.002) levels. Twelve (21.4%) patients had side effects (8.7% in the SI group vs. 30.3% in the FHPC group (p=0.006)), leading to iron discontinuation in 5 (4/1: FHPC group/SI group).
Discussion: Both iron formulations had similar efficacy. There were fewer side effects in the SI group. Oral iron replacement improved Hb and iron levels after 12 weeks of treatment, and these changes correlated with improvement in disability.
DOI: 10.5683/sp3/2vmj0j
title: Adult Training Survey, 1986 [Canada]
title: ATS 1986
title: Enquête sur la formation des adultes, 1986 [Canada]

description: The objectives of the Adult Training Survey are: &lt;BR&gt; 1. To obtain an estimate of the number of persons who took training and educational courses in 1984 and 1985 in order to improve career opportunities, to maintain or learn new skills related to their job or for personal interest; &lt;BR&gt; 2. To determine the accessibility of such education and training as relates to: a) the type of program and course offered and who organized it; b) was the person sponsored for the training through an employer or a Government Manpower program; c) the cost, was any training allowance or other financial assistance paid by Employment and Immigration Canada? &lt;BR&gt; 3. To provide an estimate of the number of persons being served by Adult Education and Training programs; &lt;BR&gt; 4. To determine the length of the Adult Training program or course followed.
description: Adult Training Survey
description: Migration from Nesstar
DOI: 10.5683/sp3/irjt7c
title: Aboriginal Peoples Survey, 1991 [Canada]
title: APS 1991
title: Enquête auprès des peuples autochtones, 1991 [Canada]

description: This public use microdata file provides unaggregated data on the Aboriginal adult population - those who identify with their Aboriginal origin(s) and those who do not. For persons who identify, it contains almost 700 variables from the 1991 survey, such as, the group with which they identify, language proficiency, disability, chronic health conditions, schooling, work experience and the 1991 Census variables such as, income levels, marital status, fertility. The same census variables are provided for the population who does not identify.
description: Aboriginal Peoples Survey
description: Migration from Nesstar
description: Notes: Files revised January 2002.;
DOI: 10.5683/sp3/5smcs7
title: Absence from Work Survey, 1981 [Canada]
title: AWS, 1981
title: Enquête sur l'absence du travail, 1981 [Canada]

description: The Absence from Work Survey was designed primarily to fulfill the objectives of Human Resources Development Canada. They sponsor the qualified wage loss replacement plan which applies to employers who have their own private plans to cover employee wages lost due to sickness, accident, etc. Employers who fall under the plan are granted a reduction in their quotas payable to the Unemployment Insurance Commission. The data generated from the responses to the supplement will provide input to determine the rates for quota reductions for qualified employers. Although the Absence from Work Survey collects information on absences from work due to illness, accident or pregnancy, it does not provide a complete picture of people who have been absent from work for these reasons because the concepts and definitions have been developed specifically for the needs of the client. Absences in this survey are defined as being at least two weeks in length, and respondents are only asked the three reasons for their most recent absence and the one preceding it. &lt;br&gt; The Absence From Work Survey, 1981, was conducted in 1980, that is, the Reference Year is 1980.
description: Absence from Work Survey
description: Migration from Nesstar
DOI: 10.5683/sp3/ckpxin
title: Absence from Work Survey, 1979 [Canada]
title: AWS, 1979
title: Enquête sur l'absence du travail, 1979 [Canada]

description: The Absence from Work Survey was designed primarily to fulfill the objectives of Human Resources Development Canada. They sponsor the qualified wage loss replacement plan which applies to employers who have their own private plans to cover employee wages lost due to sickness, accident, etc. Employers who fall under the plan are granted a reduction in their quotas payable to the Unemployment Insurance Commission. The data generated from the responses to the supplement will provide input to determine the rates for quota reductions for qualified employers. Although the Absence from Work Survey collects information on absences from work due to illness, accident or pregnancy, it does not provide a complete picture of people who have been absent from work for these reasons because the concepts and definitions have been developed specifically for the needs of the client. Absences in this survey are defined as being at least two weeks in length, and respondents are only asked the three reasons for their most recent absence and the one preceding it. &lt;br&gt; The Absence From Work Survey, 1979, was conducted in 1978, that is, the Reference Year is 1978.
description: Migration from Nesstar
description: Absence from Work Survey
DOI: 10.5683/sp3/5dieyh
title: Absence from Work Survey, 1983 [Canada]
title: AWS, 1983
title: Enquête sur l'absence du travail, 1983 [Canada]

description: The Absence from Work Survey was designed primarily to fulfill the objectives of Human Resources Development Canada. They sponsor the qualified wage loss replacement plan which applies to employers who have their own private plans to cover employee wages lost due to sickness, accident, etc. Employers who fall under the plan are granted a reduction in their quotas payable to the Unemployment Insurance Commission. The data generated from the responses to the supplement will provide input to determine the rates for quota reductions for qualified employers. Although the Absence from Work Survey collects information on absences from work due to illness, accident or pregnancy, it does not provide a complete picture of people who have been absent from work for these reasons because the concepts and definitions have been developed specifically for the needs of the client. Absences in this survey are defined as being at least two weeks in length, and respondents are only asked the three reasons for their most recent absence and the one preceding it. &lt;br&gt; The Absence From Work Survey, 1983, was conducted in 1982, that is, the Reference Year is 1982.
description: Absence from Work Survey
description: Migration from Nesstar
DOI: 10.5683/sp3/ileafh
title: Absence from Work Survey, 1980 [Canada]
title: AWS, 1980
title: Enquête sur l'absence du travail, 1980 [Canada]

description: The Absence from Work Survey was designed primarily to fulfill the objectives of Human Resources Development Canada. They sponsor the qualified wage loss replacement plan which applies to employers who have their own private plans to cover employee wages lost due to sickness, accident, etc. Employers who fall under the plan are granted a reduction in their quotas payable to the Unemployment Insurance Commission. The data generated from the responses to the supplement will provide input to determine the rates for quota reductions for qualified employers. Although the Absence from Work Survey collects information on absences from work due to illness, accident or pregnancy, it does not provide a complete picture of people who have been absent from work for these reasons because the concepts and definitions have been developed specifically for the needs of the client. Absences in this survey are defined as being at least two weeks in length, and respondents are only asked the three reasons for their most recent absence and the one preceding it. &lt;br&gt; The Absence From Work Survey, 1980, was conducted in 1979, that is, the Reference Year is 1979.
description: Migration from Nesstar
description: Absence from Work Survey