cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.1252228
title: Resistance to targeted cancer drugs through hepatocyte growth factor signaling

description: Cancer therapeutics that target a signaling pathway to which the cancer cells are addicted can deliver dramatic initial responses, but resistance is nearly always inevitable. A variety of mechanisms that cancer cells employ to escape from targeted cancer drugs have been described. We review here the role of Hepatocyte Growth Factor (HGF) and its receptor MET in drug resistance. We present data demonstrating that HGF can confer resistance to a number of kinase inhibitors in a variety of cancer cell lines and discuss our results in relation to the findings of others. Together, these data point at a major role for HGF/MET signaling in resistance to a variety of targeted cancer drugs.
DOI: 10.6084/m9.figshare.1252232.v1
title: Spotting East African Mammals in Open Savannah from Space

description: A 120 km2 GeoEye-1 satellite image on 11th August 2009 to capture the migration of the large-sized herd animals (i.e., wildebeest and zebra) in the Maasai Mara National Reserve, Kenya.
DOI: 10.6084/m9.figshare.1252228.v1
title: Resistance to targeted cancer drugs through hepatocyte growth factor signaling

description: Cancer therapeutics that target a signaling pathway to which the cancer cells are addicted can deliver dramatic initial responses, but resistance is nearly always inevitable. A variety of mechanisms that cancer cells employ to escape from targeted cancer drugs have been described. We review here the role of Hepatocyte Growth Factor (HGF) and its receptor MET in drug resistance. We present data demonstrating that HGF can confer resistance to a number of kinase inhibitors in a variety of cancer cell lines and discuss our results in relation to the findings of others. Together, these data point at a major role for HGF/MET signaling in resistance to a variety of targeted cancer drugs.
DOI: 10.6084/m9.figshare.1252229.v1
title: IFNG-mediated immune responses enhance autophagy against <i>Mycobacterium tuberculosis</i> antigens in patients with active tuberculosis

description: Protective immunity against <i>Mycobacterium tuberculosis</i> (<i>Mtb</i>) requires IFNG. Besides, IFNG-mediated induction of autophagy suppresses survival of virulent <i>Mtb</i> in macrophage cell lines. We investigated the contribution of autophagy to the defense against <i>Mtb</i> antigen (<i>Mtb</i>-Ag) in cells from tuberculosis patients and healthy donors (HD). Patients were classified as high responders (HR) if their T cells produced significant IFNG against <i>Mtb</i>-Ag; and low responders (LR) when patients showed weak or no T cell responses to <i>Mtb</i>-Ag. The highest autophagy levels were detected in HD cells whereas the lowest quantities were observed in LR patients. Interestingly, upon <i>Mtb-</i>Ag stimulation, we detected a positive correlation between IFNG and MAP1LC3B-II –II /LC3-II levels. Actually, blockage of <i>Mtb</i>-Ag-induced IFNG markedly reduced autophagy in HR patients whereas addition of limited amounts of IFNG significantly increased autophagy in LR patients. Therefore, autophagy collaborates with human immune responses against <i>Mtb</i> in close association with specific IFNG secreted against the pathogen.
DOI: 10.6084/m9.figshare.1252232.v2
title: Spotting East African Mammals in Open Savannah from Space Part III

description: A GeoEye-1 satellite image on 11th August 2009 to capture the migration of the large-sized herd animals (i.e., wildebeest and zebra) in the Maasai Mara National Reserve, Kenya.
DOI: 10.6084/m9.figshare.1252228.v2
title: Resistance to targeted cancer drugs through hepatocyte growth factor signaling

description: Cancer therapeutics that target a signaling pathway to which the cancer cells are addicted can deliver dramatic initial responses, but resistance is nearly always inevitable. A variety of mechanisms that cancer cells employ to escape from targeted cancer drugs have been described. We review here the role of Hepatocyte Growth Factor (HGF) and its receptor MET in drug resistance. We present data demonstrating that HGF can confer resistance to a number of kinase inhibitors in a variety of cancer cell lines and discuss our results in relation to the findings of others. Together, these data point at a major role for HGF/MET signaling in resistance to a variety of targeted cancer drugs.
DOI: 10.6084/m9.figshare.1252229.v2
title: IFNG-mediated immune responses enhance autophagy against <i>Mycobacterium tuberculosis</i> antigens in patients with active tuberculosis

description: Protective immunity against <i>Mycobacterium tuberculosis</i> (<i>Mtb</i>) requires IFNG. Besides, IFNG-mediated induction of autophagy suppresses survival of virulent <i>Mtb</i> in macrophage cell lines. We investigated the contribution of autophagy to the defense against <i>Mtb</i> antigen (<i>Mtb</i>-Ag) in cells from tuberculosis patients and healthy donors (HD). Patients were classified as high responders (HR) if their T cells produced significant IFNG against <i>Mtb</i>-Ag; and low responders (LR) when patients showed weak or no T cell responses to <i>Mtb</i>-Ag. The highest autophagy levels were detected in HD cells whereas the lowest quantities were observed in LR patients. Interestingly, upon <i>Mtb-</i>Ag stimulation, we detected a positive correlation between IFNG and MAP1LC3B-II/LC3-II levels. Actually, blockage of <i>Mtb</i>-Ag-induced IFNG markedly reduced autophagy in HR patients whereas addition of limited amounts of IFNG significantly increased autophagy in LR patients. Therefore, autophagy collaborates with human immune responses against <i>Mtb</i> in close association with specific IFNG secreted against the pathogen.
DOI: 10.6084/m9.figshare.1252229
title: IFNG-mediated immune responses enhance autophagy against <i>Mycobacterium tuberculosis</i> antigens in patients with active tuberculosis

description: Protective immunity against <i>Mycobacterium tuberculosis</i> (<i>Mtb</i>) requires IFNG. Besides, IFNG-mediated induction of autophagy suppresses survival of virulent <i>Mtb</i> in macrophage cell lines. We investigated the contribution of autophagy to the defense against <i>Mtb</i> antigen (<i>Mtb</i>-Ag) in cells from tuberculosis patients and healthy donors (HD). Patients were classified as high responders (HR) if their T cells produced significant IFNG against <i>Mtb</i>-Ag; and low responders (LR) when patients showed weak or no T cell responses to <i>Mtb</i>-Ag. The highest autophagy levels were detected in HD cells whereas the lowest quantities were observed in LR patients. Interestingly, upon <i>Mtb-</i>Ag stimulation, we detected a positive correlation between IFNG and MAP1LC3B-II/LC3-II levels. Actually, blockage of <i>Mtb</i>-Ag-induced IFNG markedly reduced autophagy in HR patients whereas addition of limited amounts of IFNG significantly increased autophagy in LR patients. Therefore, autophagy collaborates with human immune responses against <i>Mtb</i> in close association with specific IFNG secreted against the pathogen.
DOI: 10.6084/m9.figshare.1252232.v3
title: Spotting East African Mammals in Open Savannah from Space Part III

description: A GeoEye-1 satellite image on 11th August 2009 to capture the migration of the large-sized herd animals (i.e., wildebeest and zebra) in the Maasai Mara National Reserve, Kenya.
DOI: 10.6084/m9.figshare.1252229.v4
title: IFNG-mediated immune responses enhance autophagy against <i>Mycobacterium tuberculosis</i> antigens in patients with active tuberculosis

description: Protective immunity against <i>Mycobacterium tuberculosis</i> (<i>Mtb</i>) requires IFNG. Besides, IFNG-mediated induction of autophagy suppresses survival of virulent <i>Mtb</i> in macrophage cell lines. We investigated the contribution of autophagy to the defense against <i>Mtb</i> antigen (<i>Mtb</i>-Ag) in cells from tuberculosis patients and healthy donors (HD). Patients were classified as high responders (HR) if their T cells produced significant IFNG against <i>Mtb</i>-Ag; and low responders (LR) when patients showed weak or no T cell responses to <i>Mtb</i>-Ag. The highest autophagy levels were detected in HD cells whereas the lowest quantities were observed in LR patients. Interestingly, upon <i>Mtb-</i>Ag stimulation, we detected a positive correlation between IFNG and MAP1LC3B-II/LC3-II levels. Actually, blockage of <i>Mtb</i>-Ag-induced IFNG markedly reduced autophagy in HR patients whereas addition of limited amounts of IFNG significantly increased autophagy in LR patients. Therefore, autophagy collaborates with human immune responses against <i>Mtb</i> in close association with specific IFNG secreted against the pathogen.
DOI: 10.6084/m9.figshare.1252226
title: Spotting East African Mammals in Open Savannah from Space

description: A GeoEye-1 satellite image on 11th August 2009 to capture the migration of the large-sized herd animals (i.e., wildebeest and zebra) in the Maasai Mara National Reserve, Kenya.
DOI: 10.6084/m9.figshare.1252228.v3
title: Resistance to targeted cancer drugs through hepatocyte growth factor signaling

description: Cancer therapeutics that target a signaling pathway to which the cancer cells are addicted can deliver dramatic initial responses, but resistance is nearly always inevitable. A variety of mechanisms that cancer cells employ to escape from targeted cancer drugs have been described. We review here the role of Hepatocyte Growth Factor (HGF) and its receptor MET in drug resistance. We present data demonstrating that HGF can confer resistance to a number of kinase inhibitors in a variety of cancer cell lines and discuss our results in relation to the findings of others. Together, these data point at a major role for HGF/MET signaling in resistance to a variety of targeted cancer drugs.
DOI: 10.6084/m9.figshare.1252229.v3
title: IFNG-mediated immune responses enhance autophagy against <i>Mycobacterium tuberculosis</i> antigens in patients with active tuberculosis

description: Protective immunity against <i>Mycobacterium tuberculosis</i> (<i>Mtb</i>) requires IFNG. Besides, IFNG-mediated induction of autophagy suppresses survival of virulent <i>Mtb</i> in macrophage cell lines. We investigated the contribution of autophagy to the defense against <i>Mtb</i> antigen (<i>Mtb</i>-Ag) in cells from tuberculosis patients and healthy donors (HD). Patients were classified as high responders (HR) if their T cells produced significant IFNG against <i>Mtb</i>-Ag; and low responders (LR) when patients showed weak or no T cell responses to <i>Mtb</i>-Ag. The highest autophagy levels were detected in HD cells whereas the lowest quantities were observed in LR patients. Interestingly, upon <i>Mtb-</i>Ag stimulation, we detected a positive correlation between IFNG and MAP1LC3B-II/LC3-II levels. Actually, blockage of <i>Mtb</i>-Ag-induced IFNG markedly reduced autophagy in HR patients whereas addition of limited amounts of IFNG significantly increased autophagy in LR patients. Therefore, autophagy collaborates with human immune responses against <i>Mtb</i> in close association with specific IFNG secreted against the pathogen.
DOI: 10.6084/m9.figshare.1252232.v5
title: Spotting East African Mammals in Open Savannah from Space

description: A GeoEye-1 satellite image on 11th August 2009 to capture the migration of the large-sized herd animals (i.e., wildebeest and zebra) in the Maasai Mara National Reserve, Kenya.
DOI: 10.6084/m9.figshare.1252225
title: Three New Hg(II) Complexes Constructed From Mercapto- and Amino-Containing Triazole Ligands: Syntheses, Crystal Structures, and Luminescent Properties

description: Three new mercury(II) complexes [HgI<sub>2</sub>(3-aptt)<sub>2</sub>] (1), [Hg(4-aptt)<sub>2</sub>] (2), and [Hg(a-mtt)<sub>2</sub>]·H<sub>2</sub>O (3) were synthesized based on three structurally related ligands: 4-amino-3-(3-pyridyl)-1H-1,2,4-triazole-5-thione (3-Haptt), 4-amino-3-(4-pyridyl)-5-mercapto-1,2,4-triazole (4-Haptt), and 4-amino-3-methyl-1,2,4-triazoline-5-thiadone (a-Hmtt). The structures of complexes 1–3 were determined by single-crystal X-ray diffraction techniques and further characterized by elemental analyses and IR spectra. The results reveal that these three complexes take mononuclear structures. And although various weak interactions, including N‒H···I and N···H‒O H-bondings as well as N<sub>trz</sub>···N<sub>py</sub> and π···π stacking, play significant roles in crystal structures, just these weak interactions link the mononuclear units into higher dimensional supramolecular networks. Their thermal stabilities and the solid state luminescent properties have also been discussed.
DOI: 10.6084/m9.figshare.1252228.v5
title: Resistance to targeted cancer drugs through hepatocyte growth factor signaling

description: Cancer therapeutics that target a signaling pathway to which the cancer cells are addicted can deliver dramatic initial responses, but resistance is nearly always inevitable. A variety of mechanisms that cancer cells employ to escape from targeted cancer drugs have been described. We review here the role of Hepatocyte Growth Factor (HGF) and its receptor MET in drug resistance. We present data demonstrating that HGF can confer resistance to a number of kinase inhibitors in a variety of cancer cell lines and discuss our results in relation to the findings of others. Together, these data point at a major role for HGF/MET signaling in resistance to a variety of targeted cancer drugs.
DOI: 10.6084/m9.figshare.1252232.v4
title: Spotting East African Mammals in Open Savannah from Space Part III

description: A GeoEye-1 satellite image on 11th August 2009 to capture the migration of the large-sized herd animals (i.e., wildebeest and zebra) in the Maasai Mara National Reserve, Kenya.
DOI: 10.6084/m9.figshare.1252228.v4
title: Resistance to targeted cancer drugs through hepatocyte growth factor signaling

description: Cancer therapeutics that target a signaling pathway to which the cancer cells are addicted can deliver dramatic initial responses, but resistance is nearly always inevitable. A variety of mechanisms that cancer cells employ to escape from targeted cancer drugs have been described. We review here the role of Hepatocyte Growth Factor (HGF) and its receptor MET in drug resistance. We present data demonstrating that HGF can confer resistance to a number of kinase inhibitors in a variety of cancer cell lines and discuss our results in relation to the findings of others. Together, these data point at a major role for HGF/MET signaling in resistance to a variety of targeted cancer drugs.
DOI: 10.6084/m9.figshare.1252225.v2
title: Three New Hg(II) Complexes Constructed From Mercapto- and Amino-Containing Triazole Ligands: Syntheses, Crystal Structures, and Luminescent Properties

description: Three new mercury(II) complexes [HgI<sub>2</sub>(3-aptt)<sub>2</sub>] (1), [Hg(4-aptt)<sub>2</sub>] (2), and [Hg(a-mtt)<sub>2</sub>]·H<sub>2</sub>O (3) were synthesized based on three structurally related ligands: 4-amino-3-(3-pyridyl)-1H-1,2,4-triazole-5-thione (3-Haptt), 4-amino-3-(4-pyridyl)-5-mercapto-1,2,4-triazole (4-Haptt), and 4-amino-3-methyl-1,2,4-triazoline-5-thiadone (a-Hmtt). The structures of complexes 1–3 were determined by single-crystal X-ray diffraction techniques and further characterized by elemental analyses and IR spectra. The results reveal that these three complexes take mononuclear structures. And although various weak interactions, including N‒H···I and N···H‒O H-bondings as well as N<sub>trz</sub>···N<sub>py</sub> and π···π stacking, play significant roles in crystal structures, just these weak interactions link the mononuclear units into higher dimensional supramolecular networks. Their thermal stabilities and the solid state luminescent properties have also been discussed.
DOI: 10.6084/m9.figshare.1252226.v1
title: Spotting East African Mammals in Open Savannah from Space

description: A 120 km2 GeoEye-1 satellite image on 11th August 2009 to capture the migration of the large-sized herd animals (i.e., wildebeest and zebra) in the Maasai Mara National Reserve, Kenya.
DOI: 10.6084/m9.figshare.1252225.v1
title: Three new Hg(II) complexes constructed from mercapto- and amino-containing triazole ligands: Syntheses, crystal structures and luminescent properties

description: Three new mercury(II) complexes [HgI<sub>2</sub>(3-aptt)<sub>2</sub>] (1), [Hg(4-aptt)<sub>2</sub>] (2) and [Hg(a-mtt)<sub>2</sub>]·H<sub>2</sub>O (3) were synthesized based on three structurally related ligands: 4-amino-3-(3-pyridyl)-1H-1,2,4-triazole-5-thione (3-Haptt), 4-amino-3-(4-pyridyl)-5-mercapto-1,2,4-triazole (4-Haptt) and 4-amino-3-methyl-1,2,4-triazoline-5-thiadone (a-Hmtt). The structures of complexes 1-3 were determined by single-crystal X-ray diffraction techniques and further characterized by elemental analyses, IR spectra. The results reveal that these three complexes take mononuclear structures. And various weak interactions, including N-H···I and N···H-O H-bondings, N<sub>trz</sub>···N<sub>py</sub> and π···π stacking, play significant roles in crystal structures, just these weak interactions link the mononuclear units into higher-dimensional supramolecular networks. Their thermal stabilities and the solid state luminescent properties have also been discussed.
DOI: 10.6084/m9.figshare.1252208
title: Mapping file/Metadata: Soil bacterial community structure remains stable over a five-year chronosequence of insect-induced tree mortality

description: Mapping file and metadata categories included for the study: Soil bacterial community structure remains stable over a five-year chronosequence of insect-induced tree mortality. S Ferrenberg, JE Knelman, JM Jones, SC Beals…DR Nemergut - Frontiers in Microbiology, 2014
DOI: 10.6084/m9.figshare.1252207
title: Sequences: Soil bacterial community structure remains stable over a five-year chronosequence of insect-induced tree mortality

description: Sequences as a fastq (stripped barcode, relabled with mapping file labels provided) file associated with analysis in "Soil bacterial community structure remains stable over a five-year chronosequence of insect-induced tree mortality." S Ferrenberg, JE Knelman, JM Jones, SC Beals… DR Nemergut - Frontiers in Microbiology, 2014
DOI: 10.6084/m9.figshare.1252226.v2
title: Spotting East African Mammals in Open Savannah from Space Part II

description: A 120 km2 GeoEye-1 satellite image on 11th August 2009 to capture the migration of the large-sized herd animals (i.e., wildebeest and zebra) in the Maasai Mara National Reserve, Kenya.
DOI: 10.6084/m9.figshare.1252187
title: Ostrich knee anatomy 3D PDF

description: Interactive 3D PDF representation of ostrich knee anatomy model
DOI: 10.6084/m9.figshare.1252207.v2
title: Sequences: Soil bacterial community structure remains stable over a five-year chronosequence of insect-induced tree mortality

description: Sequences as a fastq (stripped barcode, relabled with mapping file labels provided) file associated with analysis in "Soil bacterial community structure remains stable over a five-year chronosequence of insect-induced tree mortality." S Ferrenberg, JE Knelman, JM Jones, SC Beals… DR Nemergut - Frontiers in Microbiology, 2014
DOI: 10.6084/m9.figshare.1252208.v1
title: Mapping file/Metadata: Soil bacterial community structure remains stable over a five-year chronosequence of insect-induced tree mortality

description: Mapping file and metadata categories included for the study: Soil bacterial community structure remains stable over a five-year chronosequence of insect-induced tree mortality. S Ferrenberg, JE Knelman, JM Jones, SC Beals…DR Nemergut - Frontiers in Microbiology, 2014
DOI: 10.6084/m9.figshare.1252226.v4
title: Spotting East African Mammals in Open Savannah from Space

description: A GeoEye-1 satellite image on 11th August 2009 to capture the migration of the large-sized herd animals (i.e., wildebeest and zebra) in the Maasai Mara National Reserve, Kenya.
DOI: 10.6084/m9.figshare.1252226.v3
title: Spotting East African Mammals in Open Savannah from Space Part II

description: A 120 km2 GeoEye-1 satellite image on 11th August 2009 to capture the migration of the large-sized herd animals (i.e., wildebeest and zebra) in the Maasai Mara National Reserve, Kenya.
DOI: 10.6084/m9.figshare.1252166
title: 3D Ostrich knee anatomy STL files

description: STL files comprising the 3D anatomy of an ostrich knee
DOI: 10.6084/m9.figshare.1252207.v1
title: Sequences: Soil bacterial community structure remains stable over a five-year chronosequence of insect-induced tree mortality

description: Sequences as a .fna file associated with analysis in "Soil bacterial community structure remains stable over a five-year chronosequence of insect-induced tree mortality." S Ferrenberg, JE Knelman, JM Jones, SC Beals… DR Nemergut - Frontiers in Microbiology, 2014
DOI: 10.6084/m9.figshare.1252133
title: Continental growth and reworking on the edge of the Columbia and Rodinia supercontinents; 1.86–0.9 Ga accretionary orogeny in southwest Fennoscandia

description: Geological history from the late Palaeoproterozoic to early Neoproterozoic is dominated by the formation of the supercontinent Columbia, and its break-up and re-amalgamation into the next supercontinent, Rodinia. On a global scale, major orogenic events have been tied to the formation of either of these supercontinents, and records of extension are commonly linked to break-up events. Presented here is a synopsis of the geological evolution of southwest Fennoscandia during the ca. 1.9–0.9 Ga period. This region records a protracted history of continental growth and reworking in a long-lived accretionary orogen. Three major periods of continental growth are defined by the Transscandinavian Igneous Belt (1.86–1.66 Ga), Gothian (1.66–1.52 Ga), and Telemarkian (1.52–1.48 Ga) domains. The 1.47–1.38 Ga Hallandian–Danopolonian period featured reorganization of the subduction zone and over-riding plates, with limited evidence for continental collision. During the subsequent 1.38–1.15 Ga interval, the region is interpreted as being located inboard of a convergent margin that is not preserved today and hosted magmatism and sedimentation related to inboard extensional events. The 1.15–0.9 Ga period is host to Sveconorwegian orogenesis that marks the end of this long-lived accretionary orogen and features significant crustal deformation, metamorphism, and magmatism. Collision of an indenter, typically Amazonia, is commonly inferred for the cause of widespread Sveconorwegian orogenesis, but this remains inconclusive. An alternative is that orogenesis merely represents subduction, terrane accretion, crustal thickening, and burial and exhumation of continental crust, along an accretionary margin. During the Mesoproterozoic, southwest Fennoscandia was part of a much larger accretionary orogen that grew on the edge of the Columbia supercontinent and included Laurentia and Amazonia amongst other cratons. The chain of convergent margins along the western Pacific is the best analogue for this setting of Proterozoic crustal growth and tectonism.
DOI: 10.6084/m9.figshare.1252096
title: The degenerating behaviour of Jacobi's theta functions

description: In this note, we give the degenerating behaviour of Jacobi's theta functions as the modulus <i>k</i> tends to one.