cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.25491/s77m-8081
title: GTEX-PLZ5-0626-SM-2I5F8

description: Sample ID: GTEX-PLZ5-0626-SM-2I5F8
DOI: 10.25491/tmd6-z528
title: GTEX-1C475-1626-SM-731FP

description: Sample ID: GTEX-1C475-1626-SM-731FP
DOI: 10.25491/w78e-3j96
title: GTEX-17JCI-0426-SM-7LG4R

description: Sample ID: GTEX-17JCI-0426-SM-7LG4R
DOI: 10.25491/xn4j-7984
title: GTEX-17JCI-0726-SM-7EPH1

description: Sample ID: GTEX-17JCI-0726-SM-7EPH1
DOI: 10.25491/y5ga-fk69
title: GTEX-14DAQ-2926-SM-664MV

description: Sample ID: GTEX-14DAQ-2926-SM-664MV
DOI: 10.25491/yjxh-g140
title: GTEX-1445S-3026-SM-5O9BR

description: Sample ID: GTEX-1445S-3026-SM-5O9BR
DOI: 10.25491/z228-b138
title: GTEX-15ER7-2526-SM-7KUFW

description: Sample ID: GTEX-15ER7-2526-SM-7KUFW
DOI: 10.25491/zvhj-p344
title: GTEX-17JCI-0011-R6a-SM-72D6D

description: Sample ID: GTEX-17JCI-0011-R6a-SM-72D6D
DOI: 10.25549/kada-c126-17850
title: Anne Kim Kido oral history
DOI: 10.25491/0gyw-7s27
title: GTEX-14DAR-1226-SM-73KYV

description: Sample ID: GTEX-14DAR-1226-SM-73KYV
DOI: 10.25491/0n7t-bc32
title: GTEX-17JCI-3126-SM-7LTA2

description: Sample ID: GTEX-17JCI-3126-SM-7LTA2
DOI: 10.25491/1eb5-pn80
title: GTEX-15ETS-1926-SM-7KUN5

description: Sample ID: GTEX-15ETS-1926-SM-7KUN5
DOI: 10.25491/290e-pp61
title: GTEX-1C4CL-2026-SM-731EB

description: Sample ID: GTEX-1C4CL-2026-SM-731EB
DOI: 10.25491/2w5g-7m44
title: GTEX-144FL-3126-SM-5TDCX

description: Sample ID: GTEX-144FL-3126-SM-5TDCX
DOI: 10.25491/2z0d-fb47
title: GTEX-17JCI-2926-SM-7DUFF

description: Sample ID: GTEX-17JCI-2926-SM-7DUFF
DOI: 10.25491/3n7p-bn89
title: GTEX-17JCI-2626-SM-7EWE6

description: Sample ID: GTEX-17JCI-2626-SM-7EWE6
DOI: 10.25491/3qba-qe15
title: GTEX-PLZ5-1726-SM-2I5F6

description: Sample ID: GTEX-PLZ5-1726-SM-2I5F6
DOI: 10.25491/49ag-0n76
title: GTEX-1C4CL-1626-SM-7DUF3

description: Sample ID: GTEX-1C4CL-1626-SM-7DUF3
DOI: 10.25491/4qk0-pp11
title: GTEX-PLZ5-2026-SM-2S1O4

description: Sample ID: GTEX-PLZ5-2026-SM-2S1O4
DOI: 10.25491/50nk-pc13
title: GTEX-17JCI-2826-SM-7IGNA

description: Sample ID: GTEX-17JCI-2826-SM-7IGNA
DOI: 10.25491/5ftx-2g10
title: GTEX-17JCI-2326-SM-7IGPC

description: Sample ID: GTEX-17JCI-2326-SM-7IGPC
DOI: 10.25491/6jwr-6m96
title: GTEX-PLZ6-0006-SM-33HBZ

description: Sample ID: GTEX-PLZ6-0006-SM-33HBZ
DOI: 10.25491/73qy-sa52
title: GTEX-15ETS-0626-SM-7KUMX

description: Sample ID: GTEX-15ETS-0626-SM-7KUMX
DOI: 10.25491/7egr-0x75
title: GTEX-1C4CL-0626-SM-731DM

description: Sample ID: GTEX-1C4CL-0626-SM-731DM
DOI: 10.25491/7yp2-th51
title: GTEX-144FL-2726-SM-5O98Z

description: Sample ID: GTEX-144FL-2726-SM-5O98Z
DOI: 10.25491/89kt-e692
title: GTEX-1C4CL-0926-SM-79OL2

description: Sample ID: GTEX-1C4CL-0926-SM-79OL2
DOI: 10.25491/8md6-qw37
title: GTEX-PLZ6-0008-SM-48TD5

description: Sample ID: GTEX-PLZ6-0008-SM-48TD5
DOI: 10.25491/9gvv-qs97
title: GTEX-PLZ6-0226-SM-3P61I

description: Sample ID: GTEX-PLZ6-0226-SM-3P61I
DOI: 10.25491/a7nc-tp55
title: GTEX-1C4CL-1226-SM-7DUFT

description: Sample ID: GTEX-1C4CL-1226-SM-7DUFT
DOI: 10.25491/ac1z-v045
title: GTEX-144FL-1526-SM-5Q5CA

description: Sample ID: GTEX-144FL-1526-SM-5Q5CA
DOI: 10.25491/ay35-8433
title: GTEX-144FL-3026-SM-5O99C

description: Sample ID: GTEX-144FL-3026-SM-5O99C
DOI: 10.25491/bcdh-2g81
title: GTEX-PLZ5-1626-SM-3NB21

description: Sample ID: GTEX-PLZ5-1626-SM-3NB21
DOI: 10.25491/cqzc-7k18
title: GTEX-14DAR-1526-SM-5RQIX

description: Sample ID: GTEX-14DAR-1526-SM-5RQIX
DOI: 10.25491/cz92-4m09
title: GTEX-14DAR-0926-SM-73KUQ

description: Sample ID: GTEX-14DAR-0926-SM-73KUQ
DOI: 10.25491/czw3-qd40
title: GTEX-1C4CL-0826-SM-7EWEZ

description: Sample ID: GTEX-1C4CL-0826-SM-7EWEZ
DOI: 10.25491/da2p-ma22
title: GTEX-14DAR-0526-SM-664MX

description: Sample ID: GTEX-14DAR-0526-SM-664MX
DOI: 10.25491/dkmb-4a76
title: GTEX-15ETS-1526-SM-6LPKM

description: Sample ID: GTEX-15ETS-1526-SM-6LPKM
DOI: 10.25491/eaqd-mv47
title: GTEX-14DAR-0626-SM-664MY

description: Sample ID: GTEX-14DAR-0626-SM-664MY
DOI: 10.25491/efrv-7236
title: GTEX-15ETS-0726-SM-6LPKL

description: Sample ID: GTEX-15ETS-0726-SM-6LPKL
DOI: 10.25491/evt0-3h82
title: GTEX-144FL-2626-SM-5TDCW

description: Sample ID: GTEX-144FL-2626-SM-5TDCW
DOI: 10.25491/ewx5-br82
title: GTEX-17JCI-1626-SM-7EPGZ

description: Sample ID: GTEX-17JCI-1626-SM-7EPGZ
DOI: 10.25491/frew-g648
title: GTEX-15ETS-0526-SM-6PAN3

description: Sample ID: GTEX-15ETS-0526-SM-6PAN3
DOI: 10.25491/fwa0-g822
title: GTEX-15ETS-0326-SM-6PANH

description: Sample ID: GTEX-15ETS-0326-SM-6PANH
DOI: 10.25491/fzx1-6f25
title: GTEX-17JCI-2526-SM-7DHLB

description: Sample ID: GTEX-17JCI-2526-SM-7DHLB
DOI: 10.25491/hrns-q173
title: GTEX-14DAR-1026-SM-73KV3

description: Sample ID: GTEX-14DAR-1026-SM-73KV3
DOI: 10.25491/jdpy-jf56
title: GTEX-144GL-0011-R11b-SM-5P9F6

description: Sample ID: GTEX-144GL-0011-R11b-SM-5P9F6
DOI: 10.25491/m3hd-yh22
title: GTEX-1C4CL-1426-SM-793CT

description: Sample ID: GTEX-1C4CL-1426-SM-793CT
DOI: 10.25491/n1ec-hj48
title: GTEX-PLZ5-0926-SM-4RGM9

description: Sample ID: GTEX-PLZ5-0926-SM-4RGM9
DOI: 10.25491/r2kx-rg02
title: GTEX-PLZ5-1826-SM-3NB22

description: Sample ID: GTEX-PLZ5-1826-SM-3NB22
DOI: 10.25491/r7xj-wt74
title: GTEX-15ETS-2026-SM-6AJBC

description: Sample ID: GTEX-15ETS-2026-SM-6AJBC
DOI: 10.25491/tkjq-pg42
title: GTEX-144GL-0011-R4a-SM-5PNUI

description: Sample ID: GTEX-144GL-0011-R4a-SM-5PNUI
DOI: 10.25491/w0ht-xf60
title: GTEX-PLZ5-1526-SM-3P5ZX

description: Sample ID: GTEX-PLZ5-1526-SM-3P5ZX
DOI: 10.25491/w5bv-3m25
title: GTEX-17JCI-2226-SM-7LTA1

description: Sample ID: GTEX-17JCI-2226-SM-7LTA1
DOI: 10.25491/x4me-7k29
title: GTEX-14DAR-0726-SM-5RQIA

description: Sample ID: GTEX-14DAR-0726-SM-5RQIA
DOI: 10.25491/xcs4-bw06
title: GTEX-14DAR-1126-SM-793AT

description: Sample ID: GTEX-14DAR-1126-SM-793AT
DOI: 10.25491/xqxq-wj97
title: GTEX-1C4CL-0726-SM-7IGP9

description: Sample ID: GTEX-1C4CL-0726-SM-7IGP9
DOI: 10.25491/ycgq-w914
title: GTEX-PLZ6-0006-SM-2I5FQ

description: Sample ID: GTEX-PLZ6-0006-SM-2I5FQ
DOI: 10.25491/yez7-dp28
title: GTEX-144GL-0011-R1a-SM-5PNZ5

description: Sample ID: GTEX-144GL-0011-R1a-SM-5PNZ5
DOI: 10.25491/yhxb-2e07
title: GTEX-14DAR-0826-SM-73KYJ

description: Sample ID: GTEX-14DAR-0826-SM-73KYJ
DOI: 10.25491/ykpy-q555
title: GTEX-15ETS-0426-SM-6PANI

description: Sample ID: GTEX-15ETS-0426-SM-6PANI
DOI: 10.25491/za1p-7a63
title: GTEX-144GL-0011-R3a-SM-5P9HP

description: Sample ID: GTEX-144GL-0011-R3a-SM-5P9HP
DOI: 10.25491/zm14-2108
title: GTEX-1C4CL-0426-SM-7939N

description: Sample ID: GTEX-1C4CL-0426-SM-7939N
DOI: 10.25549/kada-c126-18773
title: "Roots" Reader Feedback questionnaire, page 1
DOI: 10.25491/00y5-de06
title: GTEX-144GL-0126-SM-5TDE2

description: Sample ID: GTEX-144GL-0126-SM-5TDE2
DOI: 10.25491/02g8-3y28
title: GTEX-PLZ6-0426-SM-2I5FG

description: Sample ID: GTEX-PLZ6-0426-SM-2I5FG
DOI: 10.25491/0g3s-qt38
title: GTEX-15ETS-2426-SM-6PANJ

description: Sample ID: GTEX-15ETS-2426-SM-6PANJ
DOI: 10.25491/0kr8-jt84
title: GTEX-PLZ6-0626-SM-5J1P1

description: Sample ID: GTEX-PLZ6-0626-SM-5J1P1
DOI: 10.25491/15m5-av19
title: GTEX-14DAR-1726-SM-664MZ

description: Sample ID: GTEX-14DAR-1726-SM-664MZ
DOI: 10.25491/1x3b-t316
title: GTEX-17KNJ-0826-SM-793A4

description: Sample ID: GTEX-17KNJ-0826-SM-793A4
DOI: 10.25491/350n-eh79
title: GTEX-15EU6-1226-SM-6AJBE

description: Sample ID: GTEX-15EU6-1226-SM-6AJBE
DOI: 10.25491/4d5g-nz16
title: GTEX-144GL-0326-SM-5QGOY

description: Sample ID: GTEX-144GL-0326-SM-5QGOY
DOI: 10.25491/4etm-ad42
title: GTEX-PLZ6-0526-SM-3P61C

description: Sample ID: GTEX-PLZ6-0526-SM-3P61C
DOI: 10.25491/4nh3-m390
title: GTEX-144GL-0011-R8a-SM-5Q5B1

description: Sample ID: GTEX-144GL-0011-R8a-SM-5Q5B1
DOI: 10.25491/6awx-1s89
title: GTEX-17KNJ-0526-SM-7LTA8

description: Sample ID: GTEX-17KNJ-0526-SM-7LTA8
DOI: 10.25491/717k-w263
title: GTEX-1C64N-1026-SM-79ONM

description: Sample ID: GTEX-1C64N-1026-SM-79ONM
DOI: 10.25491/83px-9j29
title: GTEX-144GL-0226-SM-5QGOX

description: Sample ID: GTEX-144GL-0226-SM-5QGOX
DOI: 10.25491/864a-wr45
title: GTEX-1C4CL-2126-SM-7IGQC

description: Sample ID: GTEX-1C4CL-2126-SM-7IGQC
DOI: 10.25491/8fk5-m306
title: GTEX-14DAR-1926-SM-5S2NQ

description: Sample ID: GTEX-14DAR-1926-SM-5S2NQ
DOI: 10.25491/8jyh-fk04
title: GTEX-15EU6-0326-SM-6M48I

description: Sample ID: GTEX-15EU6-0326-SM-6M48I
DOI: 10.25491/ba6e-h288
title: GTEX-15EU6-1526-SM-7KUGA

description: Sample ID: GTEX-15EU6-1526-SM-7KUGA
DOI: 10.25491/bh2m-va21
title: GTEX-1C64N-3126-SM-79OO3

description: Sample ID: GTEX-1C64N-3126-SM-79OO3
DOI: 10.25491/bk0q-c667
title: GTEX-PLZ6-0626-SM-3P61B

description: Sample ID: GTEX-PLZ6-0626-SM-3P61B
DOI: 10.25491/cf6g-pg31
title: GTEX-PLZ6-0626-SM-5K7WJ

description: Sample ID: GTEX-PLZ6-0626-SM-5K7WJ
DOI: 10.25491/d5t9-ms74
title: GTEX-PLZ6-0326-SM-3P61J

description: Sample ID: GTEX-PLZ6-0326-SM-3P61J
DOI: 10.25491/e6kx-g783
title: GTEX-17JCI-3026-SM-7EWDR

description: Sample ID: GTEX-17JCI-3026-SM-7EWDR
DOI: 10.25491/eksb-j396
title: GTEX-PLZ6-0426-SM-5IJDW

description: Sample ID: GTEX-PLZ6-0426-SM-5IJDW
DOI: 10.25491/ez3t-cn82
title: GTEX-144GL-0011-R6a-SM-5P9HW

description: Sample ID: GTEX-144GL-0011-R6a-SM-5P9HW
DOI: 10.25491/fph1-4h16
title: GTEX-17KNJ-1026-SM-79ONK

description: Sample ID: GTEX-17KNJ-1026-SM-79ONK
DOI: 10.25491/gr7k-mg41
title: GTEX-15EU6-0426-SM-6PAN5

description: Sample ID: GTEX-15EU6-0426-SM-6PAN5
DOI: 10.25491/hc2d-tr74
title: GTEX-14DAR-2026-SM-5S2O3

description: Sample ID: GTEX-14DAR-2026-SM-5S2O3
DOI: 10.25491/hws4-t521
title: GTEX-1C4CL-1926-SM-731DY

description: Sample ID: GTEX-1C4CL-1926-SM-731DY
DOI: 10.25491/jshn-rw25
title: GTEX-15EU6-1126-SM-68721

description: Sample ID: GTEX-15EU6-1126-SM-68721
DOI: 10.25491/k587-fh63
title: GTEX-14DAR-1826-SM-664N1

description: Sample ID: GTEX-14DAR-1826-SM-664N1
DOI: 10.25491/kmhj-4865
title: GTEX-14DAR-2226-SM-5S2VT

description: Sample ID: GTEX-14DAR-2226-SM-5S2VT
DOI: 10.25491/m2r2-r984
title: GTEX-1C64N-2926-SM-79OLM

description: Sample ID: GTEX-1C64N-2926-SM-79OLM
DOI: 10.25491/mnvw-bd32
title: GTEX-144GL-0011-R7b-SM-5P9HX

description: Sample ID: GTEX-144GL-0011-R7b-SM-5P9HX
DOI: 10.25491/mt84-8z31
title: GTEX-14DAR-1326-SM-7DUEG

description: Sample ID: GTEX-14DAR-1326-SM-7DUEG
DOI: 10.25491/ndwf-aw65
title: GTEX-PLZ6-0126-SM-48TC6

description: Sample ID: GTEX-PLZ6-0126-SM-48TC6
DOI: 10.25491/pg69-r481
title: GTEX-PLZ6-0426-SM-5IFK2

description: Sample ID: GTEX-PLZ6-0426-SM-5IFK2
DOI: 10.25491/q0h8-fz71
title: GTEX-17KNJ-0926-SM-7IGP2

description: Sample ID: GTEX-17KNJ-0926-SM-7IGP2
DOI: 10.25491/qcen-2j38
title: GTEX-17KNJ-0626-SM-7LT9L

description: Sample ID: GTEX-17KNJ-0626-SM-7LT9L
DOI: 10.25491/qq7g-y645
title: GTEX-14DAR-2126-SM-5RQID

description: Sample ID: GTEX-14DAR-2126-SM-5RQID
DOI: 10.25491/t168-y749
title: GTEX-144GL-0011-R5b-SM-5PNUJ

description: Sample ID: GTEX-144GL-0011-R5b-SM-5PNUJ
DOI: 10.25491/t5gw-hy08
title: GTEX-15ETS-3126-SM-6LPKN

description: Sample ID: GTEX-15ETS-3126-SM-6LPKN
DOI: 10.25491/v0nn-np81
title: GTEX-1C64N-2826-SM-7IGP5

description: Sample ID: GTEX-1C64N-2826-SM-7IGP5
DOI: 10.25491/vapg-y064
title: GTEX-15EU6-0726-SM-7KUFU

description: Sample ID: GTEX-15EU6-0726-SM-7KUFU
DOI: 10.25491/vb4f-1565
title: GTEX-14DAR-1426-SM-5RQIR

description: Sample ID: GTEX-14DAR-1426-SM-5RQIR
DOI: 10.25491/vh3v-0h56
title: GTEX-17KNJ-0326-SM-7KFS5

description: Sample ID: GTEX-17KNJ-0326-SM-7KFS5
DOI: 10.25491/y52a-3r62
title: GTEX-15ETS-2326-SM-7KUGC

description: Sample ID: GTEX-15ETS-2326-SM-7KUGC
DOI: 10.25491/y9at-pk95
title: GTEX-1C64N-0011-R6a-SM-7IGO9

description: Sample ID: GTEX-1C64N-0011-R6a-SM-7IGO9
DOI: 10.25491/yk44-6c56
title: GTEX-1C64N-0126-SM-793D7

description: Sample ID: GTEX-1C64N-0126-SM-793D7
DOI: 10.25491/zdeq-b777
title: GTEX-1C64N-0011-R7a-SM-7IGOI

description: Sample ID: GTEX-1C64N-0011-R7a-SM-7IGOI
DOI: 10.25491/zfqk-8d87
title: GTEX-14E1K-0006-SM-5N9DY

description: Sample ID: GTEX-14E1K-0006-SM-5N9DY
DOI: 10.25491/zqbg-4z14
title: GTEX-17KNJ-0426-SM-718AK

description: Sample ID: GTEX-17KNJ-0426-SM-718AK
DOI: 10.25549/kada-c126-17861
title: Richard O. Hahn / Julia Kim Hahn oral history
DOI: 10.25549/kada-c126-21743
title: Balancing Debits and Credits in the Far East: China--Mongolia--Manchuria--Siberia--Korea--Japan: as between themselves and their creditors, by Fred A. Dolph

description: Fred A. Dolph served as "Counsellor to the Republic of Korea" (actually to the Korean Commission in Washington, D.C., headed by Syngman Rhee) in the period of 1919-1921. This copy was signed by the author: "To Henry Chung, my collaborator."
DOI: 10.25549/kada-m13444
title: Telephone list
DOI: 10.25491/0sjc-p735
title: GTEX-RVPU-2426-SM-2XCAR

description: Sample ID: GTEX-RVPU-2426-SM-2XCAR
DOI: 10.25491/30ng-wr69
title: GTEX-1C64O-1126-SM-7IGMY

description: Sample ID: GTEX-1C64O-1126-SM-7IGMY
DOI: 10.25491/3zyy-5z13
title: GTEX-14E1K-0626-SM-5S2PG

description: Sample ID: GTEX-14E1K-0626-SM-5S2PG
DOI: 10.25491/4jmk-va28
title: GTEX-PLZ6-1426-SM-5S2TR

description: Sample ID: GTEX-PLZ6-1426-SM-5S2TR
DOI: 10.25491/55kj-ej48
title: GTEX-17KNJ-1726-SM-7LG6A

description: Sample ID: GTEX-17KNJ-1726-SM-7LG6A
DOI: 10.25491/5j74-ys71
title: GTEX-15EU6-1626-SM-6LPKF

description: Sample ID: GTEX-15EU6-1626-SM-6LPKF
DOI: 10.25491/6ntt-2345
title: GTEX-15F5U-1426-SM-7KUN2

description: Sample ID: GTEX-15F5U-1426-SM-7KUN2
DOI: 10.25491/7zx6-t784
title: GTEX-14E1K-0826-SM-5ZZW9

description: Sample ID: GTEX-14E1K-0826-SM-5ZZW9
DOI: 10.25491/8djh-zc65
title: GTEX-1C64O-0826-SM-79OKZ

description: Sample ID: GTEX-1C64O-0826-SM-79OKZ
DOI: 10.25491/8gdc-qf49
title: GTEX-14E1K-1226-SM-5S2PD

description: Sample ID: GTEX-14E1K-1226-SM-5S2PD
DOI: 10.25491/8jje-f772
title: GTEX-PLZ6-0926-SM-3P5ZQ

description: Sample ID: GTEX-PLZ6-0926-SM-3P5ZQ
DOI: 10.25491/8jxc-5g80
title: GTEX-144GL-0626-SM-5LU4D

description: Sample ID: GTEX-144GL-0626-SM-5LU4D
DOI: 10.25491/8pgb-mb80
title: GTEX-15EU6-2626-SM-7KUN4

description: Sample ID: GTEX-15EU6-2626-SM-7KUN4
DOI: 10.25491/8t91-8b74
title: GTEX-PLZ6-0826-SM-3P61K

description: Sample ID: GTEX-PLZ6-0826-SM-3P61K
DOI: 10.25491/9kfy-0t47
title: GTEX-144GL-0426-SM-5QGOZ

description: Sample ID: GTEX-144GL-0426-SM-5QGOZ
DOI: 10.6084/m9.figshare.23993451
title: Anti-hypertensives peptides

description: Antihypertensive peptides are currently an alternative in research for the discovery of promising substances to conventional therapies. In this study, the virtual screening of promising peptides against enzymes such as ACE1 was proposed.
DOI: 10.6084/m9.figshare.23993487
title: Supplementary Material for: Associations between antiepileptic use and hypogammaglobulinaemia: Findings from a population-based case-control study using data linkage.

description: Background and objectives Increased mortality in epilepsy due to infections (other than pneumonia) has been demonstrated. Small case series of people on antiepileptic drugs (AEDs) have described hypogammaglobulinaemia, which may predispose to infections. It is unclear whether hypogammaglobulinaemia is more frequent in people on AEDs, what AEDs it is associated with, or what clinical impact it has. In this population-based study, we aimed to determine whether AEDs were associated with hypogammaglobulinaemia, which AEDs were associated, and whether the associations may be causal. Methods We conducted an unmatched case-control study using data linkage of routinely-collected biochemistry, prescribing, and morbidity datasets in North-East Scotland from 2009-2021. Cases were participants with immunoglobulin levels less than the reference range. Controls were those with normal/high immunoglobulin levels. Logistic regression was used to investigate associations between AED exposure and any hypogammaglobulinaemia, adjusting for age, sex and comorbidity. We also analysed low IgA, IgM and IgG separately. We analysed 'any AED' exposure and common individual drugs separately. Cumulative exposure data were used to determine whether an exposure-response relationship was present. Results 18,666 cases and 127,157 controls were identified. Use of any AED was associated with increased risk of hypogammaglobulinaemia (adjusted odds ratio [aOR] 1.20 [95% CI 1.15-1.25]). Phenytoin use was strongly associated with low IgA (aOR 5.90 [95% CI 3.04, 10.43]). Carbamazepine and lamotrigine were also associated with low IgA. Apart from topiramate, which was associated with a non-significant decrease in odds of hypogammaglobulinaemia, there was a consistent increase in odds of hypogammaglobulinaemia across most AEDs studied. Panhypogammaglobulinaemia was associated with any AED use, carbamazepine, lamotrigine, gabapentin and multiple AED use. There was evidence of an exposure-response relationship between any AED use and any hypogammaglobulinaemia, low IgA and low IgG. Carbamazepine and probably lamotrigine also had an exposure-response relationship with any hypogammaglobulinaemia. Discussion AEDs may increase hypogammaglobulinaemia risk. Specific classes of immunoglobulins are differentially affected, and the exposure-response analysis suggests this may be causal. Further work should investigate the clinical impact of these findings. Clinicians should check immunoglobulin levels if unusual or recurrent infections occur in patients treated with AEDs.
DOI: 10.6084/m9.figshare.23993487.v1
title: Supplementary Material for: Associations between antiepileptic use and hypogammaglobulinaemia: Findings from a population-based case-control study using data linkage.

description: Background and objectives Increased mortality in epilepsy due to infections (other than pneumonia) has been demonstrated. Small case series of people on antiepileptic drugs (AEDs) have described hypogammaglobulinaemia, which may predispose to infections. It is unclear whether hypogammaglobulinaemia is more frequent in people on AEDs, what AEDs it is associated with, or what clinical impact it has. In this population-based study, we aimed to determine whether AEDs were associated with hypogammaglobulinaemia, which AEDs were associated, and whether the associations may be causal. Methods We conducted an unmatched case-control study using data linkage of routinely-collected biochemistry, prescribing, and morbidity datasets in North-East Scotland from 2009-2021. Cases were participants with immunoglobulin levels less than the reference range. Controls were those with normal/high immunoglobulin levels. Logistic regression was used to investigate associations between AED exposure and any hypogammaglobulinaemia, adjusting for age, sex and comorbidity. We also analysed low IgA, IgM and IgG separately. We analysed 'any AED' exposure and common individual drugs separately. Cumulative exposure data were used to determine whether an exposure-response relationship was present. Results 18,666 cases and 127,157 controls were identified. Use of any AED was associated with increased risk of hypogammaglobulinaemia (adjusted odds ratio [aOR] 1.20 [95% CI 1.15-1.25]). Phenytoin use was strongly associated with low IgA (aOR 5.90 [95% CI 3.04, 10.43]). Carbamazepine and lamotrigine were also associated with low IgA. Apart from topiramate, which was associated with a non-significant decrease in odds of hypogammaglobulinaemia, there was a consistent increase in odds of hypogammaglobulinaemia across most AEDs studied. Panhypogammaglobulinaemia was associated with any AED use, carbamazepine, lamotrigine, gabapentin and multiple AED use. There was evidence of an exposure-response relationship between any AED use and any hypogammaglobulinaemia, low IgA and low IgG. Carbamazepine and probably lamotrigine also had an exposure-response relationship with any hypogammaglobulinaemia. Discussion AEDs may increase hypogammaglobulinaemia risk. Specific classes of immunoglobulins are differentially affected, and the exposure-response analysis suggests this may be causal. Further work should investigate the clinical impact of these findings. Clinicians should check immunoglobulin levels if unusual or recurrent infections occur in patients treated with AEDs.
DOI: 10.6084/m9.figshare.22643068.v1
title: The ratio of gene expression under heat-stress and non-stress conditions (HN-ratio) in human and mouse.

description: The ratio of gene expression under heat-stress and non-stress conditions (HN-ratio) in humans and mice. HN-ratio was calculated using codes used in previous papers (https://github.com/no85j/hypoxia_code). <br>
DOI: 10.6084/m9.figshare.22643068
title: The Expression Ratio (HN-ratio) of Gene Expression Under Heat-stress and Non-stress Conditions in Human and Mouse.

description: After quantifying expression using the analysis pipeline ikra (https://github.com/yyoshiaki/ikra), expression ratios (HN-ratios) were calculated for data collected in pairs of HS and non-treatment conditions. The HN-ratios calculated for all genes were then classified as "upregulated," "downregulated," or "unchanged" if neither threshold was met, according to a defined threshold (5-fold or 1/5-fold in this study). This classification facilitates the interpretation of complicated gene expression data.<br>Gene expression data retrieval, processing, and quantification were performed using ikra (ver. 2.0.1), an automated human and mouse RNA-seq data analysis pipeline. Ikra is a tool that can automatically perform all the following processes: retrieval of FASTQ format files using the fasterq-dump program in the NCBI SRA tool kit (ver. 3.0.0), read quality control, and adapter trimming using Trim_galore (ver. 0.6.6) and transcript quantification using Salmon (ver. 1.9.0). The reference sequence sets of human GENCODE Release 37 (GRCh38.p13) and mouse GENCODE Release 26 (GRCm39) were used. HN-ratio was calculated using codes used in previous papers (https://github.com/no85j/hypoxia_code).<br>
DOI: 10.6084/m9.figshare.23993484.v1
title: Untitled Item

description: This data is from the Global survey on COVID-19 self-testing using SARS-CoV-2 Ag-RDTs. It was part of the work on developing guidelines for using SARS-CoV-2 antigen-detection rapid diagnostic tests for COVID-19 self-testing.
DOI: 10.6084/m9.figshare.23993484
title: Global survey on COVID-19 self-testing using SARS-CoV-2 Ag-RDTs

description: This data is from the Global survey on COVID-19 self-testing using SARS-CoV-2 Ag-RDTs. It was part of the work on developing guidelines for using SARS-CoV-2 antigen-detection rapid diagnostic tests for COVID-19 self-testing.
DOI: 10.6084/m9.figshare.23993484.v3
title: Global survey on COVID-19 self-testing using SARS-CoV-2 Ag-RDTs

description: This data is from the Global survey on COVID-19 self-testing using SARS-CoV-2 Ag-RDTs. It was part of the work on developing guidelines for using SARS-CoV-2 antigen-detection rapid diagnostic tests for COVID-19 self-testing.
DOI: 10.6084/m9.figshare.23993484.v2
title: Untitled Item Global survey on COVID-19 self-testing using SARS-CoV-2 Ag-RDTs

description: This data is from the Global survey on COVID-19 self-testing using SARS-CoV-2 Ag-RDTs. It was part of the work on developing guidelines for using SARS-CoV-2 antigen-detection rapid diagnostic tests for COVID-19 self-testing.
DOI: 10.5281/zenodo.8264657
title: Allegheny County PM2.5 LCS data

description: Calibrated 15-min data from low-cost PM2.5 sensors deployed as a part of Center for Air, Climate, and Energy Solutions (CACES) air quality monitoring network.
DOI: 10.5281/zenodo.8264656
title: Allegheny County PM2.5 LCS data

description: Calibrated 15-min data from low-cost PM2.5 sensors deployed as a part of Center for Air, Climate, and Energy Solutions (CACES) air quality monitoring network.