cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.5281/zenodo.3732340
title: Representative images of Lepidoptera from the Natural History Museum (NHMUK)

description: Up to 10 representative images for each species of Lepidoptera from the Natural History Museum (NHMUK) iCollections project. Dataset comprises 463 taxa and 4293 images. Original iCollections dataset: https://doi.org/10.5519/0038559
DOI: 10.5281/zenodo.4550751
title: Google Trends normalized hits for COVID-19 generated in Switzerland

description: This dataset contains the normalized hits of the queries on COVID-19 generated in Switzerland between July 2019 and July 2020, the timeline of the normalized hits per Canton, the top associated queries, the frequency analysis of the top associated queries, the categorization of the top associated queries, and the rising queries. Query: Coronavirus + covid + 2019-nCoV + SARS-CoV2 Query type: keyword Timeframe: 27/07/19 - 27/07/20 Date of search: 27 07 2020 Data source: Web searches Location:CH (by canton) Query category:all Rationale for keywords: main semi-synonims for covid-19 This dataset has been generated by and used for the PubliCo research project.
DOI: 10.6084/m9.figshare.12547073
title: Modified IEEE 33-bus distribution system

description: Modified IEEE 33-bus distribution system
DOI: 10.48370/ofd/sw0abr
title: Skrzyp olbrzymi (Equisetum telmateia Ehrh.), 5266

description: Herbarium
DOI: 10.48370/ofd/sw0abr/gewyuy
title: HMW_Equisetum_telmateia_Ehrh_H_5266.tif

description: :unav
DOI: 10.48370/ofd/nv0k0w
title: Skrzyp olbrzymi (Equisetum telmateia Ehrh.), 4810

description: Herbarium
DOI: 10.48370/ofd/nv0k0w/oq28ap
title: HMW_Equisetum_telmateia_Ehrh_H_4810.tif

description: :unav
DOI: 10.20351/29gd20020915
title: TRIDENT Cruise, RV García del Cid

description: TRIDENT Cruise (29GD20020915) carried out on the Research Vessel García del Cid in 2002
DOI: 10.48370/ofd/dbv5dk
title: Skrzyp olbrzymi (Equisetum telmateia Ehrh.), 3899

description: Herbarium
DOI: 10.48370/ofd/dbv5dk/xvdm7a
title: HMW_Equisetum_telmateia_Ehrh_H_3899.tif

description: :unav
DOI: 10.6084/m9.figshare.14060951
title: Supplementary Material for: Duration of Mechanical Ventilation and Extubation Success among Extremely Premature Infants

description: <b><i>Objective:</i></b> The objective of this study was to examine the duration of mechanical ventilation (MV) in days until the first successful extubation and the cumulative duration of MV until discharge of infants with gestational age (GA) &lt;26 weeks. We also aimed to explore associations between early clinical variables and the cumulative duration of MV. <b><i>Design and Setting:</i></b> This population-based study analysed data reported to the Norwegian Neonatal Network on extremely premature infants admitted between January 1, 2013, and December 31, 2018. <b><i>Results:</i></b> A total of 406 infants were included, of which 293 (72%) survived to discharge. The proportion successfully extubated on their first attempt was 34% of the infants born at GA 22–23 weeks, 50% at GA 24 weeks, and 70% at GA 25 weeks. Median postmenstrual age (PMA) at the first successful extubation was 27 weeks. The median duration of MV was 35, 24, and 12 days for infants born at GA 22–23, 24, and 25 weeks, respectively. Male sex and low 5-min Apgar score were independent early predictors for prolonged MV duration adjusted for GA in regression analyses. <b><i>Conclusions:</i></b> Most of the infants born at GA 25 weeks were successfully extubated on the first attempt. However, half of the infants born &lt;26 weeks experienced unsuccessful extubations, indicating a lack of useful clinical predictors of successful extubation. The median duration of MV in survivors was 4 weeks longer for infants at GA 22–23 weeks than for infants born at GA 25 weeks, while the difference in median PMA at the first successful extubation was 2 weeks.
DOI: 10.20351/29gd20020901
title: ANIMATEO2-ESTOC Cruise, RV García del Cid

description: ANIMATEO2-ESTOC Cruise (29GD20020901) carried out on the Research Vessel García del Cid in 2002
DOI: 10.15468/b3yzwr
title: Two new species and new records of darkling beetles of the tribe Helopini from Turkey and Cyprus (Coleoptera: Tenebrionidae)

description: This dataset contains the digitized treatments in Plazi based on the original journal article Nabozhenko, Maxim, Keskin, Bekir, Papadopoulou, Anna (2020): Two new species and new records of darkling beetles of the tribe Helopini from Turkey and Cyprus (Coleoptera: Tenebrionidae). Acta Entomologica Musei Nationalis Pragae 60 (2): 411-417, DOI: 10.37520/aemnp.2020.25
DOI: 10.15468/ymkune
title: Rhagovelia species from Nosy Boraha east of Madagascar (Hemiptera: Heteroptera: Veliidae)

description: This dataset contains the digitized treatments in Plazi based on the original journal article Zettel, Herbert, Laciny, Alice (2020): Rhagovelia species from Nosy Boraha east of Madagascar (Hemiptera: Heteroptera: Veliidae). Acta Entomologica Musei Nationalis Pragae 60 (2): 419-425, DOI: 10.37520/aemnp.2020.26
DOI: 10.48370/ofd/umxm7u
title: Miodunka wąskolistna (Pulmonaria angustifolia L.), 6845

description: Herbarium
DOI: 10.48370/ofd/umxm7u/xsl4if
title: HMW_Pulmonaria_angustifolia_L_H_6845.jpg

description: :unav
DOI: 10.48370/ofd/cjofo8
title: Miodunka wąskolistna (Pulmonaria angustifolia L.), 8244

description: Herbarium
DOI: 10.48370/ofd/cjofo8/ibg3dz
title: HMW_Pulmonaria_angustifolia_L_H_8244.jpg

description: :unav
DOI: 10.20351/29gd20020923
title: CORAL Cruise, RV García del Cid

description: CORAL Cruise (29GD20020923) carried out on the Research Vessel García del Cid in 2002
DOI: 10.48370/ofd/yy4bkp
title: Miodunka wąskolistna (Pulmonaria angustifolia L.), 6534

description: Herbarium
DOI: 10.48370/ofd/yy4bkp/ydadvx
title: HMW_Pulmonaria_angustifolia_L_H_6534.jpg

description: :unav
DOI: 10.48370/ofd/xgmk6d
title: Miodunka wąskolistna (Pulmonaria angustifolia L.), 1008

description: Herbarium
DOI: 10.48370/ofd/xgmk6d/cbnjla
title: HMW_Pulmonaria_angustifolia_L_H_1008.jpg

description: :unav
DOI: 10.20351/29gd20020528
title: HUELVA Cruise, RV García del Cid


description: HUELVA Cruise (29GD20020528) carried out on the Research Vessel García del Cid in 2002
DOI: 10.15468/pk8v84
title: A new species and new records of palicoid crabs (Crustacea, Decapoda, Brachyura, Palicoidea, Palicidae, Crossotonotidae) from the Indo-West Pacific region

description: This dataset contains the digitized treatments in Plazi based on the original journal article Castro, Peter (2010): A new species and new records of palicoid crabs (Crustacea, Decapoda, Brachyura, Palicoidea, Palicidae, Crossotonotidae) from the Indo-West Pacific region. Zoosystema 32 (1): 73-86, DOI: 10.5252/z2010n1a3, URL: http://www.bioone.org/doi/abs/10.5252/z2010n1a3
DOI: 10.48370/ofd/0azhxi
title: Miodunka wąskolistna (Pulmonaria angustifolia L.), 4701

description: Herbarium
DOI: 10.48370/ofd/0azhxi/mqhgrw
title: HMW_Pulmonaria_angustifolia_L_H_4701.jpg

description: :unav
DOI: 10.5517/ccdc.csd.cc27613m
title: CCDC 2061379: Experimental Crystal Structure Determination

description: Related Article: O.A.A.A. Allah, M. Kaur, M. Akkurt, S.K. Mohamed, J.P. Jasinski, S.M.I. Elgarhy|2021|Acta Crystallogr.,Sect.E:Cryst.Commun.|77|247|doi:10.1107/S2056989021001341
DOI: 10.5517/ccdc.csd.cc2761j1
title: CCDC 2061392: Experimental Crystal Structure Determination

description: Related Article: S.K. Mohamed, J.T. Mague, M. Akkurt, M.R. Albayati, S.M.I. Elgarhy, E.A. Al-Taifi|2021|Acta Crystallogr.,Sect.E:Cryst.Commun.|77|242|doi:10.1107/S2056989021001353
DOI: 10.5517/ccdc.csd.cc2761k2
title: CCDC 2061393: Experimental Crystal Structure Determination

description: Related Article: S.K. Mohamed, J.T. Mague, M. Akkurt, M.R. Albayati, S.M.I. Elgarhy, E.A. Al-Taifi|2021|Acta Crystallogr.,Sect.E:Cryst.Commun.|77|242|doi:10.1107/S2056989021001353
DOI: 10.5517/ccdc.csd.cc276df9
title: CCDC 2061730: Experimental Crystal Structure Determination

description: Related Article: M. Kanagawa, K. Akagi, T. Okuno|2021|IUCrData|6|x210142|doi:10.1107/S2414314621001425
DOI: 10.5517/ccdc.csd.cc276n37
title: CCDC 2061968: Experimental Crystal Structure Determination

description: Related Article: D.F. Mertsalov, V.P. Zaytsev, K.M. Pokazeev, M.S. Grigoriev, A.V. Bachinsky, S.T. Çelikesir, M. Akkurt, S. Mlowe|2021|Acta Crystallogr.,Sect.E:Cryst.Commun.|77|255|doi:10.1107/S2056989021001481
DOI: 10.20351/29gd20030721
title: CACO-1 Cruise, RV García del Cid

description: CACO-1 Cruise (29GD20030721) carried out on the Research Vessel García del Cid in 2003
DOI: 10.5281/zenodo.4550783
title: DIAMONT Data

description: Between 2004 and 2008, the INTERREG IIIb-project DIAMONT has collected a huge amount of information. To allow its easy access, use, documentation, and further exploitation by local stakeholders, the project results are stored and publicly available in an online database. The DIAMONT Data provides information about the status of municipalities in manifold fields of development and allows stakeholders to carry out benchmark analysis for their respective municipality in comparison to other municipalities across the Alpine Convention area. It is dedicated to support sound and transparent decision-making on regional and local level based on statistical data and a transnational collection of regional development instruments. Conceived with the steering bodies of the Alpine Convention, the DIAMONT data represents a vital impulse to the relaunch of SOIA, the System for the Observation of and Information on the Alps, and its newly designed objectives. DIAMONT Data structure The DIAMONT Data is structured in "classes", which refer to central deliverables of the DIAMONT project including indicators, data, maps and instruments, and metadata documentation on the presented indicators, data and maps itself.
description: INTERREG IIIb-project
DOI: 10.5281/zenodo.4550782
title: DIAMONT Data

description: Between 2004 and 2008, the INTERREG IIIb-project DIAMONT has collected a huge amount of information. To allow its easy access, use, documentation, and further exploitation by local stakeholders, the project results are stored and publicly available in an online database. The DIAMONT Data provides information about the status of municipalities in manifold fields of development and allows stakeholders to carry out benchmark analysis for their respective municipality in comparison to other municipalities across the Alpine Convention area. It is dedicated to support sound and transparent decision-making on regional and local level based on statistical data and a transnational collection of regional development instruments. Conceived with the steering bodies of the Alpine Convention, the DIAMONT data represents a vital impulse to the relaunch of SOIA, the System for the Observation of and Information on the Alps, and its newly designed objectives. DIAMONT Data structure The DIAMONT Data is structured in "classes", which refer to central deliverables of the DIAMONT project including indicators, data, maps and instruments, and metadata documentation on the presented indicators, data and maps itself.
description: INTERREG IIIb-project
DOI: 10.25345/c5wn51
title: MassIVE MSV000086914 - GNPS Archangium violaceum SDU8
title: LC/MS-based metabolomics was performed on ethyl acetate extract of SDU8.
DOI: 10.6084/m9.figshare.13713232
title: Data.zip

description: Data Availability Statement<br>
DOI: 10.6084/m9.figshare.13713232.v1
title: Data.zip

description: Data Availability Statement<br>
DOI: 10.17033/data.00000109
title: CLEVER: Creative Leadership

description: An international research project into Creative Leadership developing new understanding and pedagogy about how creative and humanities skills and practices can drive economic impact through powering a more productive, innovative and impactful creative industries sector. The project developed a definition of ‘Creative Leadership’ as a concept, designed pedagogies to teach these skills to student and businesses and collated impact evidence to support policy changes in Israel around the creative industries. The European partners were the University of Brighton; Iceland Academy of the Arts: Copenhagen Institute of Interaction Design; Creative Business Cup Denmark; Estonia Business School; Creative Estonia, THNK Netherland. The Israeli partners were from the education sector: Shenkar Institute of Engineering, Art & Design: Bezalel Academy of Arts & Design, Sapir Academic College, Hadassah Academic College, The College of Management Academic Studies and from the policy sector, Lahav (Israeli Chamber of Commerce), JVP Fund (Investors) and ISMEA (Israeli Small and Medium Enterprises Authority) The University of Brighton (Close and Boddington) led on the development of the Creative Leadership Education Roadmap. This included a Literature and Contextual Review, an international Creative Leadership seminar which took place in July 2016 and featured speakers from the RSA, Arts Council, Design Council and Cabinet Office. Close developed a Creative Leadership framework model and toolkit to shape both academic and industry learning, and applied this to the creation of a new L5 module and industry/ LLL focused programme in Creative Leadership. The L5 module was run with visiting Israeli students over 2 academic years. The sandbox was run as professional development for Israeli professors over two years.
description: Evidence and Literature Review Practical test with focus groups
DOI: 10.20351/29gd20021024
title: PASTA Cruise, RV García del Cid

description: PASTA Cruise (29GD20021024) carried out on the Research Vessel García del Cid in 2002
DOI: 10.17033/data.00000111
title: SOS:Rare: Multidisciplinary research towards a secure and environmentally sustainable supply of critical rare earth elements (Nd and HREE)

description: The SoS RARE project was a consortium project funded by NERC and EPSRC under the Security of Supply of Mineral Resources (SoS Minerals) science programme, running from 2015 to 2019. The research team included 17 investigators from six UK universities and research institutes, with ten industry partners and eight core international research collaborators. The project developed from two NERC-funded catalyst grants, GEM-CREE and MM-FREE. The project aimed to improve understanding of how the rare earth elements (REE) are concentrated in natural systems, and use this information to investigate more efficient and environmentally friendly ways to extract and recover the REE. It was divided into two strands: the first concentrates on conventional bedrock deposits of the REE whilst the second focuses on ion adsorption clay deposits.
description: Geochemical data collected by: 1. XRF 2. XRD 3. EMPA 4. Sequential extraction or Bulk digestion (li metaborate fusion) then ICP-MS. 5. Radioisotope data by Laser ablation multicollector ICP-MS. 6. Stable isotope mass spectrometry. 7. Synchrotron XAS. 8. XPS.
DOI: 10.17033/data.00000116
title: Accelerated low water corrosion: the microbial sulfur cycle in microcosm

description: ccelerated low water corrosion is a form of marine steel corrosion caused by bacterial activity. It has a global spread and is potentially responsible for billions of pounds of damage. We have determined in detail both the chemistry of corrosion products and the associated microbiology at a UK site. The corrosion products form a layered structure with iron sulfides at the steel surface and iron oxides and sulfates in contact with water. The iron sulfides are formed by reaction of steel with hydrogen sulfide formed by sulfate-reducing bacteria and are oxidised through a series of sulfur oxidation states by sulfide-oxidising bacteria, forming acid at all stages and encompassing the whole of the bacterial sulfur cycle. The bacteria involved are endemic in anoxic bed sediment, and the process is a response to the presence of steel as an electron donor, and the generation of anoxic microenvironments within corrosion products.
description: Data collected by 16s RNA profiling and Geochip metagenomic profiling of DNA and RNA extracted from marine sediment, seawater and steel corrosion products.
DOI: 10.48370/ofd/hf2bje
title: Pięciornik srebrny (Potentilla argentea L. s. str.), 7988

description: Herbarium
DOI: 10.48370/ofd/hf2bje/sckkfu
title: HMW_Potentilla_argentea_L_s_str_H_7988.jpg

description: :unav
DOI: 10.15468/d4dg2n
title: Révision du genre Paradorodocia Machatschke, 1957 (Insecta, Coleoptera, Rutelidae, Adoretinae)

description: This dataset contains the digitized treatments in Plazi based on the original journal article Montreuil, Olivier (2010): Révision du genre Paradorodocia Machatschke, 1957 (Insecta, Coleoptera, Rutelidae, Adoretinae). Zoosystema 32 (1): 87-99, DOI: 10.5252/z2010n1a4, URL: http://www.bioone.org/doi/abs/10.5252/z2010n1a4
DOI: 10.48370/ofd/tru1wb
title: Manna jadalna (Glyceria fluitans (L.) R. Br.), 8992

description: Herbarium
DOI: 10.48370/ofd/tru1wb/tinrig
title: HMW_Glyceria_fluitans_L_R_Br_H_8992.jpg

description: :unav
DOI: 10.48370/ofd/eql3ns
title: Manna jadalna (Glyceria fluitans (L.) R. Br.), 9011

description: Herbarium
DOI: 10.48370/ofd/eql3ns/jzfjyr
title: HMW_Glyceria_fluitans_L_R_Br_H_9011.jpg

description: :unav
DOI: 10.48370/ofd/a8fi2v
title: Manna jadalna (Glyceria fluitans (L.) R. Br.), 8983

description: Herbarium
DOI: 10.48370/ofd/a8fi2v/uqf201
title: HMW_Glyceria_fluitans_L_R_Br_H_8983.jpg

description: :unav
DOI: 10.48370/ofd/kedkf9
title: Manna jadalna (Glyceria fluitans (L.) R. Br.), 8623

description: Herbarium
DOI: 10.48370/ofd/kedkf9/vb70jn
title: HMW_Glyceria_fluitans_L_R_Br_H_8623.jpg

description: :unav
DOI: 10.48370/ofd/wzmixm
title: Manna jadalna (Glyceria fluitans (L.) R. Br.), 8169

description: Herbarium
DOI: 10.48370/ofd/wzmixm/zfpqbb
title: HMW_Glyceria_fluitans_L_R_Br_H_8169.jpg

description: :unav
DOI: 10.48370/ofd/fjztyf
title: Manna jadalna (Glyceria fluitans (L.) R. Br.), 6125

description: Herbarium
DOI: 10.48370/ofd/fjztyf/lfobmj
title: HMW_Glyceria_fluitans_L_R_Br_H_6125.jpg

description: :unav
DOI: 10.48370/ofd/znjgwf
title: Manna jadalna (Glyceria fluitans (L.) R. Br.), 3352

description: Herbarium
DOI: 10.48370/ofd/znjgwf/ju6yzv
title: HMW_Glyceria_fluitans_L_R_Br_H_3352.jpg

description: :unav
DOI: 10.48370/ofd/idsgdi
title: Manna jadalna (Glyceria fluitans (L.) R. Br.), 9168

description: Herbarium
DOI: 10.48370/ofd/idsgdi/mfkzoi
title: HMW_Glyceria_fluitans_L_R_Br_H_9168.jpg

description: :unav
DOI: 10.48370/ofd/ebe1l4
title: Manna jadalna (Glyceria fluitans (L.) R. Br.), 9223

description: Herbarium
DOI: 10.48370/ofd/ebe1l4/b1unc0
title: HMW_Glyceria_fluitans_L_R_Br_H_9223.jpg

description: :unav
DOI: 10.48370/ofd/bqtz79
title: Manna jadalna (Glyceria fluitans (L.) R. Br.), 8645

description: Herbarium
DOI: 10.48370/ofd/bqtz79/guxhdq
title: HMW_Glyceria_fluitans_L_R_Br_H_8645.jpg

description: :unav
DOI: 10.48370/ofd/t8z1na
title: Manna jadalna (Glyceria fluitans (L.) R. Br.), 8598

description: Herbarium
DOI: 10.48370/ofd/t8z1na/0vypvd
title: HMW_Glyceria_fluitans_L_R_Br_H_8598.jpg

description: :unav
DOI: 10.48370/ofd/zgk9ts
title: Manna jadalna (Glyceria fluitans (L.) R. Br.), 8590

description: Herbarium
DOI: 10.48370/ofd/zgk9ts/vtrces
title: HMW_Glyceria_fluitans_L_R_Br_H_8590.jpg

description: :unav
DOI: 10.48370/ofd/x7criu
title: Manna jadalna (Glyceria fluitans (L.) R. Br.), 7956

description: Herbarium
DOI: 10.48370/ofd/x7criu/imdpbu
title: HMW_Glyceria_fluitans_L_R_Br_H_7956.jpg

description: :unav
DOI: 10.5519/qd.vqk4ny5q
title: Query on the Natural History Museum Data Portal (data.nhm.ac.uk) (17 records)
DOI: 10.48370/ofd/otvrka
title: Manna jadalna (Glyceria fluitans (L.) R. Br.), 6968

description: Herbarium
DOI: 10.48370/ofd/otvrka/iugny2
title: HMW_Glyceria_fluitans_L_R_Br_H_6968.jpg

description: :unav
DOI: 10.48370/ofd/s4und8
title: Manna jadalna (Glyceria fluitans (L.) R. Br.), 5572

description: Herbarium
DOI: 10.48370/ofd/s4und8/vksin5
title: HMW_Glyceria_fluitans_L_R_Br_H_5572.jpg

description: :unav
DOI: 10.48370/ofd/p2xqds
title: Manna jadalna (Glyceria fluitans (L.) R. Br.), 4941

description: Herbarium
DOI: 10.48370/ofd/p2xqds/e3kzec
title: HMW_Glyceria_fluitans_L_R_Br_H_4941.jpg

description: :unav
DOI: 10.48370/ofd/gy5ask
title: Manna jadalna (Glyceria fluitans (L.) R. Br.), 4578

description: Herbarium
DOI: 10.48370/ofd/gy5ask/6kcvuj
title: HMW_Glyceria_fluitans_L_R_Br_H_4578.jpg

description: :unav
DOI: 10.48370/ofd/kokfui
title: Manna jadalna (Glyceria fluitans (L.) R. Br.), 4483

description: Herbarium
DOI: 10.48370/ofd/kokfui/6cn5vu
title: HMW_Glyceria_fluitans_L_R_Br_H_4483.jpg

description: :unav
DOI: 10.48370/ofd/tpis3f
title: Manna jadalna (Glyceria fluitans (L.) R. Br.), 2858

description: Herbarium
DOI: 10.48370/ofd/tpis3f/pngivd
title: HMW_Glyceria_fluitans_L_R_Br_H_2858.jpg

description: :unav
DOI: 10.48370/ofd/srl1gn
title: Manna jadalna (Glyceria fluitans (L.) R. Br.), 2857

description: Herbarium
DOI: 10.48370/ofd/srl1gn/cznups
title: HMW_Glyceria_fluitans_L_R_Br_H_2857.jpg

description: :unav
DOI: 10.48370/ofd/xg6jyi
title: Manna jadalna (Glyceria fluitans (L.) R. Br.), 3200

description: Herbarium
DOI: 10.48370/ofd/xg6jyi/0xaawc
title: HMW_Glyceria_fluitans_L_R_Br_H_3200.jpg

description: :unav
DOI: 10.48370/ofd/19viqr
title: Manna jadalna (Glyceria fluitans (L.) R. Br.), 2856

description: Herbarium
DOI: 10.48370/ofd/19viqr/0vu0xd
title: HMW_Glyceria_fluitans_L_R_Br_H_2856.jpg

description: :unav
DOI: 10.48370/ofd/vtfmnr
title: Manna jadalna (Glyceria fluitans (L.) R. Br.), 2855

description: Herbarium
DOI: 10.48370/ofd/vtfmnr/znhfqt
title: HMW_Glyceria_fluitans_L_R_Br_H_2855.jpg

description: :unav
DOI: 10.48370/ofd/plblgc
title: Manna jadalna (Glyceria fluitans (L.) R. Br.), 6155

description: Herbarium
DOI: 10.48370/ofd/plblgc/gcpdv1
title: HMW_Glyceria_fluitans_L_R_Br_H_6155.jpg

description: :unav
DOI: 10.48370/ofd/lfxbq7
title: Manna jadalna (Glyceria fluitans (L.) R. Br.), 716

description: Herbarium
DOI: 10.48370/ofd/lfxbq7/wf82lu
title: HMW_Glyceria_fluitans_L_R_Br_H_0716.jpg

description: :unav
DOI: 10.6084/m9.figshare.9896480
title: GLCCI1 and STIP1 variants are associated with asthma susceptibility and inhaled corticosteroid response in a Tunisian population

description: <b>Objective:</b> Pharmacogenetic studies have recognized specific genes that highly correlate with response to inhaled corticosteroids (ICS) treatment in asthma patients. Among the genes identified, we selected glucocorticoid-induced transcript 1 (<i>GLCCI1</i>) and stress-induced phosphoprotein 1 (<i>STIP1</i>) to evaluate the impact of these gene polymorphisms on ICS treatment response in Tunisian asthmatics. <b>Methods:</b> We analyzed four single nucleotide polymorphisms (SNPs): two in <i>GLCCI1</i> (rs37972 and rs37973), and two in <i>STIP1</i> (rs2236647 and rs2236648), which are genes associated with susceptibility to asthma and response to ICS in a Tunisian cohort. The SNPs were genotyped using reverse transcriptase polymerase chain reaction (RT-PCR) techniques. <b>Results:</b> This case–control study consisted of 230 adult asthmatic patients and 236 healthy subjects. Seventy-five asthmatics were selected and followed through 12 weeks of routine treatment. The T allele rs2236648 in <i>STIP1</i> was associated with allergic asthma (OR = 0.38, 95%CI = 0.20–0.69, <i>p</i> = 0.001). The rs37972 and rs37973 of <i>GLCCI1</i> were associated with a higher risk of asthma (<i>p</i> p p p <b>Conclusion:</b> The rs37972 and rs37973 polymorphisms can serve as potential asthma risk biomarkers in a Tunisian population.