cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.16445535.v1
title: Supplementary Material for: The Regulation of Prototype Foamy Virus 5′Long Terminal Repeats and Internal Promoter by Endogenous Transcription Factors

description: <b><i>Background:</i></b> For foamy virus, the transactivator of spumaretrovirus (Tas) could bind directly to target DNA sequences termed as Tas responsive elements and trigger the viral internal promoter (IP) and long terminal repeat (LTR) promoters. The cellular endogenous factors also play an important role in viral gene expressions. We hypothesized that except the viral transcription factor Tas, the cellular endogenous factors also affect the viral gene expression. <b><i>Methods:</i></b> The full length of the prototype foamy virus (PFV) genome (U21247) was used to predict the potential binding sites of the transcription factors by online software JASPAR (http://jaspar.genereg.net) and Softberry (http://linux1.softberry.com/berry.phtml?topic=index&group=programs&subgroup=promoter). The Dual-Luciferase<sup>®</sup> Reporter Assay System (Promega, USA) was used to confirm the relative luciferase activities of the test groups. The different representative activating agents or inhibitors of each canonical signal pathway were used to identify the impact of these pathways on PFV 5′LTR and IP promoters. <b><i>Results:</i></b> The results showed different cellular endogenous factors might have respective effects on PFV 5′LTR and IP. It is worth mentioning that activator protein-1 and BCL2-associated athanogene 3, 2 kinds of vital proteins associated with NF-κB and PKC pathways, could activate the basal activity of 5′LTR and IP promoters but inhibit the Tas-regulated activity of both promoters. Furthermore, PFV Tas was identified to trigger the transcription of the NF-κB promoter. <b><i>Conclusion:</i></b> NF-κB had a negative effect on PFV 5′LTR and IP promoter activities, the PKC pathway might upregulate 5′LTR and IP promoter activities, and the JNK and NF-AT signal pathway could increase the Tas-regulated promoter activity of PFV 5′LTR. This study sheds light on the interaction between PFV and the host cell and may help utilize the viral promoters in retroviral vectors designed for gene transfer experiments.
DOI: 10.17632/yhyf2cs7s8
title: Supplementary tables for "Cutaneous T-cell lymphoma following dupilumab use: A systematic review"

description: In this systematic review, we aimed to evaluate reported cases of CTLC following dupilumab use and identify characteristics, histologic findings, and timeline of CTCL development. Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines was performed using PubMed and Embase databases (Figure 1). Key search terms were: “mycosis fungoides and dupilumab”,  “cutaneous T cell lymphoma and dupilumab”, “sezary and dupilumab”. Additional relevant studies were identified using the reference lists from the included articles. Studies reporting at least one patient who developed CTCL, such as mycosis fungoides (MF) or sezary syndrome (SS), after dupilumab treatment for an initial diagnosis other than CTCL, or studies demonstrating exacerbation of CTCL with dupilumab were included. Letters from the editor and cases reporting clinical improvement of MF or SS after dupilumab therapy were excluded. Two reviewers (A.P. and A.E.) independently assessed the articles. Data extracted included: study type, patient demographics, preliminary diagnosis, initial treatment, duration of dupilumab treatment, clinical signs and symptoms, sites involved, body surface area involved, TNM classification/tumor stage, pre- and post-dupilumab histopathologic features, time to biopsy after dupilumab, immunohistochemical phenotype, TCR gene rearrangement, final diagnosis, treatment, and clinical outcome.
DOI: 10.6084/m9.figshare.11822160.v1
title: Aldosterone in obesity: supplementary data

description: Supplementary data on the associations of aldosterone with inflammatory and metabolic markers in obesity
DOI: 10.6084/m9.figshare.3309424.v1
title: UNH tow tank and turbine test bed CAD files

description: Full SolidWorks 2016 CAD assembly for the UNH tow tank and turbine test bed.
DOI: 10.21233/hbxn-5984
title: Tangra Yumco ostracode surface sample dataset

description: Raw data for the Tangra Yumco ostracode surface sample dataset submitted to the Neotoma Paleoecology Database. Data is available through the landing page in JSON format. The landing page referenced by the DOI also contains links to publications and a map-based viewer for the dataset. The Neotoma Paleoecology Database maintains a homepage at https://www.neotomadb.org.
DOI: 10.6084/m9.figshare.10032866.v1
title: Distinct effects of reward and navigation history on hippocampal forward and reverse replays

description: This zip directory contains the raw data for reproducing the results reported in the associated paper.Contact: Baburam Bhattarai (bobs.iom@gmail.com)
DOI: 10.6084/m9.figshare.16930297.v1
title: Supplementary Material for: Features of childhood growth, lifestyle and environment associated with a cardiometabolic risk score in young adults

description: Introduction: In young adults, the metabolic syndrome is rare. To better assess the risks for future cardiovascular disease, a cardiometabolic score can be used, ranking the disease risk in each subject. The score is a continuous variable summarising the individual z-scores for waist circumference, blood pressure, blood levels of glucose, triglycerides and HDL-cholesterol. Our main aim was to assess the association between early childhood growth and the cardiometabolic score in young adults. Methods: Study participants were recruited among subjects in the longitudinal population-based GrowUp 1990 Gothenburg study. Those with information on weight and length at birth, as well as weight, height, waist circumference, and parental BMI at ten years of age were invited to participate in a health survey at 18-20 years of age. 513 young adults (female 51%) were included. Multivariable linear stepwise regression analysis was applied. Results: The mean (SD) BMI was 22.2 (3.26) in males and 21.3 (2.69) kg/m² in females; the cardiometabolic score was 0.24 (3.12) and -0.22 (3.18), respectively. A statistically significantly higher score (p&lt;0.001) was seen in individuals with metabolic syndrome, as defined by IDF. After controlling for adult lifestyle features, BMI z-score at ten years of age was significant risk factor in both sexes for an elevated cardiometabolic score in early adulthood, mean(SE) beta 0.47(0.19), p=0.014 in males, 0.82(017) p&lt;0.0001 in females. In males, high maternal BMI and low age at adiposity rebound and in females high birth weight were also associated with a statistically significant risk. Additionally, contraceptive use in females was a risk factor for elevated cardiometabolic score and, in males a high lifestyle related index score showed a protective association with the cardiometabolic score. Conclusion: A high BMI z-score at ten years of age is a risk factor for the cardiometabolic state in young adults, an outcome points to the preventive potential of monitoring BMI in ten-year-old schoolchildren. This finding must however be validated in a new large cohort. Moreover, in young adults in whom metabolic syndrome is rare, a cardiometabolic score seems to be a promising approach and potentially a more powerful tool to detect risks for cardiovascular disease later in life, than using metabolic syndrome categorisation.
DOI: 10.6084/m9.figshare.22189252.v1
title: Compound specific isotopes of sitosterol/cholesterol in gutless annelids, seagrass, porewater from Elba, Italy

description: The data set contains compound-specific carbon isotope measurements of the lipid biomarkers sitosterol and cholesterol in the gutless annelids Olavius algarvensis and Olavius ilvae, which were collected from the sediment by scuba diving in the Bay of Sant' Andrea on the Island of Elba in Italy. Further, compound-specific carbon isotopes of sitosterol was measured for the seagrass plants <em>Posidonia oceanica</em>, which were collected at the seagrass meadows from the same site where the gutless annelids were collected. For <em>Posidonia oceanica</em>, leaves and rhizomes were measured separately for their compound-specific δ<sup>13</sup>C values . Finally, porewater samples were collected near the seagrass meadows and filtered porewater samples were measured for the compound-specific δ<sup>13</sup>C values of cholesterol and sitosterol as well.<br> Generally, sitosterol is known as lipid biomarker of plants, whereas cholesterol is produced by animals. In the studied gutless annelids, however, sitosterol is the most abundant sterol, accompanied by cholesterol. The aim was to find out if the gutless annelids aquire their sterols from the environment by passive diffusion, or if they can produce sitosterol de novo. The δ<sup>13</sup>C values of sitosterol in the gutless annelids was ranging from -38 to -36‰, whereas sitosterol in the seagrass and porewater was between -30 to -29‰ and -19 to -15‰, respectively. The difference in the isotope signature of the sitosterol in both <em>Olavius</em> species and their environment (Seagrass and Porewater) excludes, that the gutless annelids aquired their sterols form the environment. Instead, the gutless worms get all their nutrition from chemosynthetic bacterial symbionts, which is reflected by the bulk carbon isotopic composition of the worms (-31‰). The δ<sup>13</sup>C values of the cholesterol and sitosterol varies by 1 to 10‰ to bulk biomass in the gutless annelids. It is hypothesized, that the worms synthesize their sterols de novo, using carbon sources from their chemosynthetic symbionts.
DOI: 10.6084/m9.figshare.13699366.v1
title: miR-200 family knockout induces senescence in gastric cancer

description: To investigate differentially expressed genes in AGS with complete miR-200 family knockout by multiplex CRISPR system (A31) compared to non target control (NTC) and parental cell line (Par).
DOI: 10.6084/m9.figshare.5598361.v1
title: Supplementary Material for: Screening of Skin Lesion-Associated Genes in Patients with Psoriasis by Meta-Integration Analysis

description: <b><i>Aim:</i></b> Psoriasis is an inflammatory skin disease, and approximately one quarter of individuals with psoriasis develop painful and debilitating arthritis. As a complex and polygenetic hereditary disease, it is significant to investigate skin lesion-associated genes of psoriasis. <b><i>Method:</i></b> In the present study, a total of 3,047 differentially expressed genes between lesional and nonlesional skin of psoriasis patients were screened based on 4 data sets in GEO DataSets. In the following, network module analyses were performed. <b><i>Result:</i></b> After calculating the correlation coefficients between eigenvalues of each module and disease status (psoriatic lesion and nonlesion), it was observed that the genes in black and green modules showed a significant correlation in each data set. Consequently, 58 significant characteristic genes of black modules and 74 of green modules were chosen for further analysis. The interaction network of the candidate feature genes was constructed based on the BioGRID, HPRD, and BIND databases, which contained 310 nodes. The mutual relationships of 70 genes, including 28 genes in the black module and 42 genes in the green module, were summarized, and 5 drug molecules related to these 70 factors were detected. Mepacrine and camptothecin were indicated as 2 drugs negatively related to psoriasis. <b><i>Conclusion:</i></b> The results suggested a pathogenesis mechanism of psoriasis and indicated novel therapeutic targets for psoriasis.
DOI: 10.6084/m9.figshare.19142627.v1
title: Meteorology dataset at subbasions

description: Temperature (T), precipitation (P) and potential evaporation (PET)) at subbasin scales.
DOI: 10.6084/m9.figshare.19603702.v1
title: PHROG-annotated webervirus genomes (n=107) used in pangenome analysis

description: PHROG-annotated GenBank and MAG files for high-quality and complete webervirus genomes included in this study.
DOI: 10.6084/m9.figshare.22592197.v1
title: Supplementary Material for: Distinguishing intracranial diabetes-related atherosclerotic plaques : A high-resolution MRI-based radiomics study

description: Introduction: Diabetes markedly affects the formation and development of intracranial atherosclerosis. The study was aimed at evaluating whether radiomics features can help distinguish plaques primarily associated with diabetes. Materials and Methods: We retrospectively analyzed patients who were admitted to our center because of acute ischemic stroke due to intracranial atherosclerosis between 2016 and 2022. Clinical data, blood biomarkers, conventional plaque features and plaque radiomics features were collected for all patients. Odds ratios (ORs) with 95% confidence intervals (CIs) were determined from logistic regression models. The receiver operating characteristic (ROC) curve and area under the ROC curve (AUC) were used to describe diagnostic performance. The DeLong test was used to compare differences between models. Results: Overall, 157 patients (115 men; mean age, 58.7 ± 10.7 years) were enrolled. Multivariate logistic regression analysis showed that plaque length (OR: 1.17; 95% CI: 1.07–1.28) and area (OR: 1.13; 95% CI: 1.02–1.24) were independently associated with diabetes. On combining plaque length and area as a conventional model, the AUCs of the training and validation cohorts for identifying diabetes patients were 0.789 and 0.720, respectively. On combining radiomics features on T1WI and contrast-enhanced T1WI sequences, a better diagnostic value was obtained in the training and validation cohorts (AUC: 0.889 and 0.861). The DeLong test showed the model combining radiomics and conventional plaque features performed better than the conventional model in both cohorts (p &lt; 0.05). Conclusions: The use of radiomics features of intracranial plaques on hrMRI can effectively distinguish culprit plaques with diabetes as the primary pathological cause, which will provide new avenues of research into plaque formation and precise treatment.
DOI: 10.6084/m9.figshare.17726300
title: Supplementary Material for: Real-World Effects of Antibiotic Treatment on Acute COPD Exacerbations in Outpatients: A Cohort Study under the PharmLines Initiative

description: <b><i>Background:</i></b> Although antibiotic treatment is recommended for acute exacerbations of chronic obstructive pulmonary disease (AECOPD), its value in real-world settings is still controversial. <b><i>Objectives:</i></b> This study aimed to evaluate the short- and long-term effects of antibiotic treatment on AECOPD outpatients. <b><i>Methods:</i></b> A cohort study was conducted under the PharmLines Initiative. We included participants with a first recorded diagnosis of COPD who received systemic glucocorticoid treatment for an AECOPD episode. The exposed and reference groups were defined based on any antibiotic prescription during the AECOPD treatment. The short-term outcome was AECOPD treatment failure within 14–30 days after the index date. The long-term outcome was time to the next exacerbation. Adjustment for confounding was made using propensity scores. <b><i>Results:</i></b> Of the 1,105 AECOPD patients, antibiotics were prescribed to 518 patients (46.9%) while 587 patients (53.1%) received no antibiotics. The overall antibiotic use was associated with a relative risk reduction of AECOPD treatment failure by 37% compared with the reference group (adjusted odds ratio [aOR] 0.63 [95% CI: 0.40–0.99]). Protective effects were similar for doxycycline, macrolides, and co-amoxiclav, although only the effect of doxycycline was statistically significant (aOR 0.53 [95% CI: 0.28–0.99]). No protective effect was seen for amoxicillin (aOR 1.49 [95% CI: 0.78–2.84]). The risk of and time to the next exacerbation was similar for both groups. <b><i>Conclusion:</i></b> Overall, antibiotic treatment, notably with doxycycline, supplementing systemic glucocorticoids reduces short-term AECOPD treatment failure in real-world outpatient settings. No long-term beneficial effects of antibiotic treatment on AECOPD were found for the prevention of subsequent exacerbations.
DOI: 10.6084/m9.figshare.1534592.v1
title: Example of use of BiRO #1

description: Defining bibliographic references and reference lists.
DOI: 10.6084/m9.figshare.20022520.v1
title: Development of infants presented with congenital syphilis in their first months of life

description: ABSTRACT Purpose: to evaluate the cognitive, language, and motor development of infants with congenital syphilis in their first months of life. Methods: a sample of 52 infants, from 21 to 112 days of age, born in public maternity hospitals, divided into a study group of 28 infants with congenital syphilis and a control group 24 infants without risk indicators for hearing loss. They underwent the Neonatal Hearing Screening Protocol with automated Brainstem Auditory Evoked Potential. The research instrument was the Bayley-III Scale, consisting of the cognitive, language (receptive and expressive), and motor (fine and gross) subscales. The raw scores were entered into the software that accompanies the Bayley-III scale kit to calculate the scores (scaled and composite) and perform qualitative analysis. The Mann-Whitney test and the Wilcoxon test was applied and used a 5% significance level. Results: a similarity between groups for the demographic parameters, maternal education level, and socioeconomic level, was seen. There was no statistically significant difference between groups when comparing the cognitive, receptive language, expressive language, fine motor, and gross motor subscales. Conclusion: infants with congenital syphilis treated at birth have a cognitive, language, and motor development within that expected for their age group in their first months of life.
DOI: 10.6084/m9.figshare.28880858.v1
title: Table S1. (a) Life history trait and (b) physiology datasets. (c) Sample size for each treatment and sex. Correlation analysis between (d) the life-history traits (Spearman correlation) and (e) physiological (Pearson correlation) traits for each treatment separately.

description: Table S1. (a) Life history trait and (b) physiology datasets. (c) Sample size for each treatment and sex. Correlation analysis between (d) the life-history traits (Spearman correlation) and (e) physiological (Pearson correlation) traits for each treatment separately.
DOI: 10.17632/pnj7km68n9
title: Journal of Islamic Education; No. 11

description: The main goal of the JIE is to publish the researches conducted in the field of religious and Islamic education, to provide scientific information on the latest scientific achievements, to provide a platform for the exchange of opinions and competing views of scholars and researchers in this field, to provide a platform for the production of educational science, circulating ideast, and theorizing in the field and ready creating a sustainable ground for the growth and development of the official education in Iran and Muslim societies in line with the Islamic education. The topics that are of interest to the journal are as follows:

The journal is set to publish original articles on a wide range of issues including;

 Philosophy of Islamic education;
 Schools and approaches to Islamic education;
 Educational jurisprudence (Fiqh);
 Foundations, principles and methodology of Islamic education;
 History of Islamic education;
 Educational thoughts, views and ideas of Muslim scholars;
 Educational sciences such as educational management, curriculum planning and educational psychology with an Islamic approach;
 Comparative studies;
 The areas and dimensions of education in Islam include religious education, devotional education, moral education, sexual education, political education, and so on;
 Methodology of research in Islamic education;
 Examining different aspects of formal education with Islamic perspective;
 Religious education in the thought of international scholars, a comparative approach to Islamic education.

JIE is an international, professional refereed journal in the interdisciplinary fields that relevant to Islamic education. JIE serves as a platform for presenting and discussing the emerging issues on Islamic education. The journal is committed in publishing high quality articles in persian and welcomes articles in English, ranging from original research papers in the area of Islamic education. This journal welcomes original and qualified researches on all aspects of Islamic education and religious education. The topics may include, but are not limited to: 
Philosophy of Islamic education, schools and approaches in Islamic education, educational Islamic jurisprudence, foundations, principles and methods of Islamic education, history of Islamic education, educational approaches and ideas of Muslim scholars, educational management, curriculum and educational planning, educational psychology with an Islamic perspective, comparative issues, areas and dimensions of education in Islam, religious education, devotional education, moral education, sexual education, political education, research methodology in Islamic education and examination of various aspects of formal education with an Islamic outlook.
DOI: 10.6084/m9.figshare.28756328.v1
title: Supporting Table S8

description: Supporting Table S8.<b> </b>Comparison of genes associated with energy metabolism, ferritinand spiralin among ten strains of the Citri (red headers) and Poulsonii (blue headers)clades. Green cells = we infer that the gene is functional. Yellow/red cells = gene isabsent or inferred as non-functional (e.g. too short). Locus tags and or protein IDs aregiven for some. Files used to identify genomes encoding (pseudo)gene for “1-acyl-sn-glycerol-3-phosphate acyltransferase” and Alpha/beta hydrolase or lysophosphatase,lysophosphatase” of “alpha/beta hydrolase” are found in Supporting Dataset S22
DOI: 10.6084/m9.figshare.24659421.v2
title: Towards more circular building services: A social footprint of the sectors manufacturing and remanufacturing chillers for the European market (structural path analysis files)

description: This data is linked to the article published in The International Journal of Life Cycle Assessment with the same title. The data presents the results of three structural path analyses focusing on three different countries manufacturing chillers, i.e., China, Italy, and Czechia. A specific social impact category is investigated in each country, i.e., Association and barganing rights, Migration flows, and Gender wage gap, respectively. All three structural path analyses were performed using the pyspa package (https://github.com/hybridlca/pyspa).