cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.6151340.v1
title: Molecular evolution and functional divergence of alcohol dehydrogenases in animals, fungi and plants

description: Abstract Alcohol dehydrogenases belong to the large superfamily of medium-chain dehydrogenases/reductases, which occur throughout the biological world and are involved with many important metabolic routes. We considered the phylogeny of 190 ADH sequences of animals, fungi, and plants. Non-class III Caenorhabditis elegans ADHs were seen closely related to tetrameric fungal ADHs. ADH3 forms a sister group to amphibian, reptilian, avian and mammalian non-class III ADHs. In fishes, two main forms are identified: ADH1 and ADH3, whereas in amphibians there is a new ADH form (ADH8). ADH2 is found in Mammalia and Aves, and they formed a monophyletic group. Additionally, mammalian ADH4 seems to result from an ADH1 duplication, while in Fungi, ADH formed clusters based on types and genera. The plant ADH isoforms constitute a basal clade in relation to ADHs from animals. We identified amino acid residues responsible for functional divergence between ADH types in fungi, mammals, and fishes. In mammals, these differences occur mainly between ADH1/ADH4 and ADH3/ADH5, whereas functional divergence occurred in fungi between ADH1/ADH5, ADH5/ADH4, and ADH5/ADH3. In fishes, the forms also seem to be functionally divergent. The ADH family expansion exemplifies a neofunctionalization process where reiterative duplication events are related to new activities.
DOI: 10.6084/m9.figshare.6151337
title: Combined effects of melatonin and topical hypothermia on renal ischemia-reperfusion injury in rats

description: Abstract Purpose: To evaluate whether their combination was more effective than either alone in decreasing renal damage due to ischemia/reperfusion (I/R) injury in rats. Methods: Thirty-two Wistar rats were assigned to four groups. Following right nephrectomy, their left kidneys were subjected to warm ischemia (IR), cold ischemia (TH+IR), intraperitoneal injection of 10 mg/kg melatonin (MEL+IR), or injection of 10 mg/kg melatonin followed by cold ischemia (MEL+TH+IR). Eight randomly assigned right kidneys constituted the control group. After 240 min of reperfusion, left nephrectomy was performed for histopathological evaluation, lipid peroxidation, and measurement of antioxidant enzyme activity. Serum was collected to measure urea and creatinine concentrations. Results: Histopathological damage induced by ischemia and reperfusion was more attenuated in the MEL+TH+IR group than in the MEL+IR and TH+IR groups (p&lt;0.037). Superoxide dismutase activity was significantly higher (p&lt;0.029) and creatinine (p&lt;0.001) and urea (p&lt;0.001) concentrations were significantly lower in the MEL+TH+IR group than in the MEL+IR and TH+IR groups. Conclusion: The combination of melatonin (MEL) and topical hypothermia (TH) better protects against renal I/R injury than does MEL or TH alone.
DOI: 10.6084/m9.figshare.6151337.v1
title: Combined effects of melatonin and topical hypothermia on renal ischemia-reperfusion injury in rats

description: Abstract Purpose: To evaluate whether their combination was more effective than either alone in decreasing renal damage due to ischemia/reperfusion (I/R) injury in rats. Methods: Thirty-two Wistar rats were assigned to four groups. Following right nephrectomy, their left kidneys were subjected to warm ischemia (IR), cold ischemia (TH+IR), intraperitoneal injection of 10 mg/kg melatonin (MEL+IR), or injection of 10 mg/kg melatonin followed by cold ischemia (MEL+TH+IR). Eight randomly assigned right kidneys constituted the control group. After 240 min of reperfusion, left nephrectomy was performed for histopathological evaluation, lipid peroxidation, and measurement of antioxidant enzyme activity. Serum was collected to measure urea and creatinine concentrations. Results: Histopathological damage induced by ischemia and reperfusion was more attenuated in the MEL+TH+IR group than in the MEL+IR and TH+IR groups (p&lt;0.037). Superoxide dismutase activity was significantly higher (p&lt;0.029) and creatinine (p&lt;0.001) and urea (p&lt;0.001) concentrations were significantly lower in the MEL+TH+IR group than in the MEL+IR and TH+IR groups. Conclusion: The combination of melatonin (MEL) and topical hypothermia (TH) better protects against renal I/R injury than does MEL or TH alone.
DOI: 10.6084/m9.figshare.6151334
title: Effect of Different Synthesis Methods on the Textural Properties of Calcium Tungstate (CaWO4) and Its Catalytic Properties in the Toluene Oxidation

description: Calcium tungstate (CaWO4) crystals were prepared by microwave-assisted hydrothermal (MAH) and polymeric precursor methods (PPM). These crystals were structurally characterized by X-ray diffraction (XRD), N2 adsorption, X-ray absorption near edge spectroscopy (XANES) and extended X-ray absorption fine structure (EXAFS) measurements. The morphology and size of these crystals were observed by field emission scanning electron microscopy (FE-SEM). Their optical properties were investigated by ultraviolet visible (UV-Vis) absorption and photoluminescence (PL) measurements. Moreover, these materials were employed as catalysts towards gas phase toluene oxidation reaction. XRD indicates the purity of materials for both preparation methods and MAH process produced crystalline powders synthesized at lower temperatures and shorter processing time compared to the ones prepared by PPM. FE-SEM images showed particles with rounded morphology and particles in clusters dumbbells-like shaped. PL spectra exhibit a broad band covering the visible electromagnetic spectrum in the range of 360 to 750 nm. XANES and EXAFS results show that preparation method does not introduce high disorders into the structure, however the H2-TPR results indicated that the catalyst reducibility is affected by the preparation method of the samples.
DOI: 10.6084/m9.figshare.6151334.v1
title: Effect of Different Synthesis Methods on the Textural Properties of Calcium Tungstate (CaWO4) and Its Catalytic Properties in the Toluene Oxidation

description: Calcium tungstate (CaWO4) crystals were prepared by microwave-assisted hydrothermal (MAH) and polymeric precursor methods (PPM). These crystals were structurally characterized by X-ray diffraction (XRD), N2 adsorption, X-ray absorption near edge spectroscopy (XANES) and extended X-ray absorption fine structure (EXAFS) measurements. The morphology and size of these crystals were observed by field emission scanning electron microscopy (FE-SEM). Their optical properties were investigated by ultraviolet visible (UV-Vis) absorption and photoluminescence (PL) measurements. Moreover, these materials were employed as catalysts towards gas phase toluene oxidation reaction. XRD indicates the purity of materials for both preparation methods and MAH process produced crystalline powders synthesized at lower temperatures and shorter processing time compared to the ones prepared by PPM. FE-SEM images showed particles with rounded morphology and particles in clusters dumbbells-like shaped. PL spectra exhibit a broad band covering the visible electromagnetic spectrum in the range of 360 to 750 nm. XANES and EXAFS results show that preparation method does not introduce high disorders into the structure, however the H2-TPR results indicated that the catalyst reducibility is affected by the preparation method of the samples.
DOI: 10.6084/m9.figshare.6151331
title: Marijuana and pregnancy: cannabis hyperemesis syndrome - Case report

description: ABSTRACT The authors report a case from the psychiatric department of a general hospital (Santa Casa de Misericordia at Sorocaba city, São Paulo, Brazil). A patient, 19-year-old, pregnant woman, marijuana chronic user, presenting abdominal pain, psychomotor agitation, unmanageable nausea, severe vomiting, not responsive to antiemetic drugs, associated with compulsive hot water showering. Cannabinoid hyperemesis syndrome is sub-diagnosed and rare, characterized by those three symptoms: heavy marijuana use, vomiting and repeated hot showering. There is no prior report in Brazilian medical literature. This paper aims to emphasize the importance of recognizing and categorizing this syndrome and its correlation to marijuana use. Main treatment is supportive care, withdrawing substance and supportive carries to suspension of marijuana use as well as clinical complications prevention.
DOI: 10.6084/m9.figshare.6151331.v1
title: Marijuana and pregnancy: cannabis hyperemesis syndrome - Case report

description: ABSTRACT The authors report a case from the psychiatric department of a general hospital (Santa Casa de Misericordia at Sorocaba city, São Paulo, Brazil). A patient, 19-year-old, pregnant woman, marijuana chronic user, presenting abdominal pain, psychomotor agitation, unmanageable nausea, severe vomiting, not responsive to antiemetic drugs, associated with compulsive hot water showering. Cannabinoid hyperemesis syndrome is sub-diagnosed and rare, characterized by those three symptoms: heavy marijuana use, vomiting and repeated hot showering. There is no prior report in Brazilian medical literature. This paper aims to emphasize the importance of recognizing and categorizing this syndrome and its correlation to marijuana use. Main treatment is supportive care, withdrawing substance and supportive carries to suspension of marijuana use as well as clinical complications prevention.
DOI: 10.6084/m9.figshare.6151328
title: Hyponatremia associated with antidepressants: a review

description: ABSTRACT Objective Review the most recent literature about the association between hyponatremia and antidepressives’ intake. Methods Bibliographic search in PubMed and SciELO databases, with the MeSH terms “antidepressive agents” and “hyponatremia”, including articles between January 2006 and May 2016. Results A total of 45 articles have been included. Age, female sex and polymedication are the main risk factors and symptoms depend on hyponatremia severity. Hyponatremia may have several causes, being the most common the syndrome of inappropriate antidiuretic hormone secretion. Between the selective serotonin reuptake inhibitors, citalopram and escitalopram presented a bigger risk, similarly to venlafaxine. Risk of hyponatremia seems smaller with the other antidepressives’ classes, with exception to monoamine oxidase inhibitors. An ionogram previously to the treatment, for patients older than 60 years, and an ionogram, always, one month after the beginning of the treatment. The first step for the treatment is the discontinuance of the drug, reverting most of the mild cases. However, treatment must be individualized, considering hyponatremia's risks and correction's risks. Conclusions Hyponatremia is a side effect to consider in patients taking antidepressants. When maintaining the treatment is needed, the same antidepressive or other of the same class, must be avoided. Options are trazodone, bupropiom, agomelatine, mirtazapine and reboxetine, because there's only a few cases of hyponatremia with these drugs.
DOI: 10.6084/m9.figshare.6151328.v1
title: Hyponatremia associated with antidepressants: a review

description: ABSTRACT Objective Review the most recent literature about the association between hyponatremia and antidepressives’ intake. Methods Bibliographic search in PubMed and SciELO databases, with the MeSH terms “antidepressive agents” and “hyponatremia”, including articles between January 2006 and May 2016. Results A total of 45 articles have been included. Age, female sex and polymedication are the main risk factors and symptoms depend on hyponatremia severity. Hyponatremia may have several causes, being the most common the syndrome of inappropriate antidiuretic hormone secretion. Between the selective serotonin reuptake inhibitors, citalopram and escitalopram presented a bigger risk, similarly to venlafaxine. Risk of hyponatremia seems smaller with the other antidepressives’ classes, with exception to monoamine oxidase inhibitors. An ionogram previously to the treatment, for patients older than 60 years, and an ionogram, always, one month after the beginning of the treatment. The first step for the treatment is the discontinuance of the drug, reverting most of the mild cases. However, treatment must be individualized, considering hyponatremia's risks and correction's risks. Conclusions Hyponatremia is a side effect to consider in patients taking antidepressants. When maintaining the treatment is needed, the same antidepressive or other of the same class, must be avoided. Options are trazodone, bupropiom, agomelatine, mirtazapine and reboxetine, because there's only a few cases of hyponatremia with these drugs.
DOI: 10.6084/m9.figshare.6151322
title: Factors influencing the impact of oral health on the daily activities of adolescents, adults and older adults

description: ABSTRACT OBJECTIVE: Analyze if clinical, sociodemographic and access to dental services variables influence the impact of oral health on the daily activities of adolescents, adults and older adults. METHODS: A cross-sectional study with secondary data from the State Oral Health Survey (SB São Paulo 2015) conducted in 163 cities of São Paulo. A total of 17,560 individuals from three age groups: 15–19-year-old (n = 5,558), 35–44-year-old (n = 6,051), and older people of 65 years or more (n = 5,951) participated in the survey. The selection was made by probabilistic sample by conglomerates in two stages. The endpoint variable was the impact of oral health on daily activities, evaluated by the Oral Impacts on Daily Performances questionnaire, containing questions about eating, talking, oral hygiene, relaxation, sports practice, smile, study or work, social contact, and sleep. Oral Impacts on Daily Performances was dichotomized with and without impact. The independent variables were sociodemographic, clinical and access variables, divided into three blocks. A hierarchical multiple logistic regression analysis was performed considering the complex sampling plan of clusters. Each observation received a specific weight, depending on the location that resulted in weighted frequencies and adjusted for the design effect. RESULTS: The presence of oral health impact was observed in 27.9% of the individuals. In block 1, female gender and black/brown ethnic group had a greater chance of impact of oral health on quality of life, as well as the adults and the older adults in relation to adolescents. In block 2, family income up to R$1,500 was associated with the presence of impact. In block 3, individuals who reported toothache, used the public service and sought dental treatment had a greater chance of impact. CONCLUSIONS: Sociodemographic, clinical and access to health services variables influence the impact of oral health on the daily activities of adolescents, adults and older adults.
DOI: 10.6084/m9.figshare.6151322.v1
title: Factors influencing the impact of oral health on the daily activities of adolescents, adults and older adults

description: ABSTRACT OBJECTIVE: Analyze if clinical, sociodemographic and access to dental services variables influence the impact of oral health on the daily activities of adolescents, adults and older adults. METHODS: A cross-sectional study with secondary data from the State Oral Health Survey (SB São Paulo 2015) conducted in 163 cities of São Paulo. A total of 17,560 individuals from three age groups: 15–19-year-old (n = 5,558), 35–44-year-old (n = 6,051), and older people of 65 years or more (n = 5,951) participated in the survey. The selection was made by probabilistic sample by conglomerates in two stages. The endpoint variable was the impact of oral health on daily activities, evaluated by the Oral Impacts on Daily Performances questionnaire, containing questions about eating, talking, oral hygiene, relaxation, sports practice, smile, study or work, social contact, and sleep. Oral Impacts on Daily Performances was dichotomized with and without impact. The independent variables were sociodemographic, clinical and access variables, divided into three blocks. A hierarchical multiple logistic regression analysis was performed considering the complex sampling plan of clusters. Each observation received a specific weight, depending on the location that resulted in weighted frequencies and adjusted for the design effect. RESULTS: The presence of oral health impact was observed in 27.9% of the individuals. In block 1, female gender and black/brown ethnic group had a greater chance of impact of oral health on quality of life, as well as the adults and the older adults in relation to adolescents. In block 2, family income up to R$1,500 was associated with the presence of impact. In block 3, individuals who reported toothache, used the public service and sought dental treatment had a greater chance of impact. CONCLUSIONS: Sociodemographic, clinical and access to health services variables influence the impact of oral health on the daily activities of adolescents, adults and older adults.
DOI: 10.6084/m9.figshare.6151316
title: Debating US Military Strategy in the Persian Gulf: What is the Way Forward?

description: Abstract Should the US strategy toward the Gulf be one of offshore balancing or one of deep engagement? The debate on US grand strategy lacks solid empirical ground. I address this issue by providing a study of the US´ role as the Gulf’s security provider. I investigate the extent to which distinct military strategies have affected the stability of the region. My findings show no clear correlation between increased US military presence and a reduction in either the incidence or the intensity of regional armed conflict, possibly lending credibility to the arguments of the advocates of a strategy of offshore balancing.
DOI: 10.6084/m9.figshare.6151316.v1
title: Debating US Military Strategy in the Persian Gulf: What is the Way Forward?

description: Abstract Should the US strategy toward the Gulf be one of offshore balancing or one of deep engagement? The debate on US grand strategy lacks solid empirical ground. I address this issue by providing a study of the US´ role as the Gulf’s security provider. I investigate the extent to which distinct military strategies have affected the stability of the region. My findings show no clear correlation between increased US military presence and a reduction in either the incidence or the intensity of regional armed conflict, possibly lending credibility to the arguments of the advocates of a strategy of offshore balancing.
DOI: 10.6084/m9.figshare.6151313
title: TiO2 thin Films for Biofouling Applications

description: This work presents a study of TiO2 thin films prepared by sputtering, for using as protection for biofouling action on marine structures. Titanium oxide thin films were prepared with different amount of oxygen on the surface of regular 1020 steel, a structural material for marine technology. The cristalline structure analysis evidenced the formation of anatase and rutile phases, as well as an amorphous phase of titanium oxide. Roughness measurements shown that the surface finish can contribute to the fixation of microorganisms. The crystalline TiO2 thin films was evaluated as a potential biofouling protective coating. Contact angle measurements revealed that under UV-C light, the material evidenced a changing in wettability from hydrophobic to hydrophilic behavior, what is associated to the activation of photocatalytic reactions that is nocive for living beings on its surface. The effect of marine ambient on sample corroborates this conclusion, where after 6 months of exposure it was not sufficient for growing of biofouling on surface.
DOI: 10.6084/m9.figshare.6151313.v1
title: TiO2 thin Films for Biofouling Applications

description: This work presents a study of TiO2 thin films prepared by sputtering, for using as protection for biofouling action on marine structures. Titanium oxide thin films were prepared with different amount of oxygen on the surface of regular 1020 steel, a structural material for marine technology. The cristalline structure analysis evidenced the formation of anatase and rutile phases, as well as an amorphous phase of titanium oxide. Roughness measurements shown that the surface finish can contribute to the fixation of microorganisms. The crystalline TiO2 thin films was evaluated as a potential biofouling protective coating. Contact angle measurements revealed that under UV-C light, the material evidenced a changing in wettability from hydrophobic to hydrophilic behavior, what is associated to the activation of photocatalytic reactions that is nocive for living beings on its surface. The effect of marine ambient on sample corroborates this conclusion, where after 6 months of exposure it was not sufficient for growing of biofouling on surface.
DOI: 10.6084/m9.figshare.6151310
title: Subzygomatic and infraorbital approaches for maxillary nerve blockade in cats’ cadaver

description: ABSTRACT: This study compared the accuracy of dye placement on the maxillary nerve by using the percutaneous subzigomatic (SBZ) and infraorbitary (IO) approaches in cats’ cadavers. A second aim was to compare the accuracy of dye placement on the maxillary nerve between different untrained anesthetists. This was a prospective, randomized, blinded study, performed in 40 heads obtained from feline cadavers. Three veterinarians (A, B and C) with no previous experience with the IO approach performed the experiments. The SBZ approach was randomly performed on one side of the head and the IO approach was performed in the contralateral side of the same head. For each approach, 0.2ml of 1% methylene blue dye was injected. Scores for length of nerve staining were as follows: 0 (failure), no staining; 1 (moderate), &lt;6mm of nerve stained; and 2 (ideal), ≥6mm of nerve stained. Median scores (interquartile range) for the SBZ and IO approaches were 2.0 (0.3-2.0) and 1.0 (0.0-2.0), respectively. Scores for length of nerve staining were higher with the SBZ approach than the IO approach (P=0.016). Considering the scores for both the SBZ and IO approaches, there was a significant difference among the three veterinarians (P=0.002). Results of this study do not support the IO approach to perform a maxillary nerve block in cats. A greater accuracy of methylene blue dye placement was observed with the SBZ approach. A variable accuracy may exist between different veterinarians when performing a maxillary nerve block employing the SBZ and IO techniques in cats.
DOI: 10.6084/m9.figshare.6151310.v1
title: Subzygomatic and infraorbital approaches for maxillary nerve blockade in cats’ cadaver

description: ABSTRACT: This study compared the accuracy of dye placement on the maxillary nerve by using the percutaneous subzigomatic (SBZ) and infraorbitary (IO) approaches in cats’ cadavers. A second aim was to compare the accuracy of dye placement on the maxillary nerve between different untrained anesthetists. This was a prospective, randomized, blinded study, performed in 40 heads obtained from feline cadavers. Three veterinarians (A, B and C) with no previous experience with the IO approach performed the experiments. The SBZ approach was randomly performed on one side of the head and the IO approach was performed in the contralateral side of the same head. For each approach, 0.2ml of 1% methylene blue dye was injected. Scores for length of nerve staining were as follows: 0 (failure), no staining; 1 (moderate), &lt;6mm of nerve stained; and 2 (ideal), ≥6mm of nerve stained. Median scores (interquartile range) for the SBZ and IO approaches were 2.0 (0.3-2.0) and 1.0 (0.0-2.0), respectively. Scores for length of nerve staining were higher with the SBZ approach than the IO approach (P=0.016). Considering the scores for both the SBZ and IO approaches, there was a significant difference among the three veterinarians (P=0.002). Results of this study do not support the IO approach to perform a maxillary nerve block in cats. A greater accuracy of methylene blue dye placement was observed with the SBZ approach. A variable accuracy may exist between different veterinarians when performing a maxillary nerve block employing the SBZ and IO techniques in cats.