cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.29133781
title: Validation of a Lenvatinib Assay: A Pilot Study

description: Lenvatinib has demonstrated efficacy in improving progression-free and overall survival in patients with radioiodine refractory thyroid cancer. However, treatment-related adverse events (TRAEs) frequently cause dose interruptions and suboptimal dosing, underscoring the importance of monitoring of lenvatinib levels. Currently, there is no validated lenvatinib assay for clinical use. We describe the development of a mass spectrometry assay for accurate quantification of lenvatinib, along with a pilot study reporting peak and trough levels. A pilot prospective single-center study was conducted at Royal North Shore Hospital, to develop and validate an in-house high-performance liquid chromatography tandem mass spectrometry (LC-MS/MS) assay for measuring plasma lenvatinib levels in patients with radioiodine refractory thyroid cancer. Patient data including dosage, TRAEs, and disease progression were recorded. Lenvatinib doses ranged between 4 mg to 14 mg daily. Trough and peak levels were measured in nine and eight patients respectively. Duration of treatment ranged from 7 to 63 months (mean 29 months), with treatment duration at the time of testing ranging from 1 to 14 months. Trough levels ranged from 4.60 to 30.53 µg/L (median 21.74 µg/L). Peak levels for patients receiving 10 mg (<i>n</i> = 3) ranged from 78.50 to 237.72 µg/L (median 129.56 µg/L), while those receiving 14 mg (<i>n</i> = 4) ranged from 65.10 to 263.64 µg/L (median 185.23 µg/L). Our study describes the successful development of a novel LC-MS/MS assay for quantifying plasma lenvatinib levels. Despite consistent dosing, we observed considerable variability in levels in this group. Further research is required to examine the utility of lenvatinib drug monitoring in the setting of thyroid cancer.
DOI: 10.6084/m9.figshare.29133781.v1
title: Validation of a Lenvatinib Assay: A Pilot Study

description: Lenvatinib has demonstrated efficacy in improving progression-free and overall survival in patients with radioiodine refractory thyroid cancer. However, treatment-related adverse events (TRAEs) frequently cause dose interruptions and suboptimal dosing, underscoring the importance of monitoring of lenvatinib levels. Currently, there is no validated lenvatinib assay for clinical use. We describe the development of a mass spectrometry assay for accurate quantification of lenvatinib, along with a pilot study reporting peak and trough levels. A pilot prospective single-center study was conducted at Royal North Shore Hospital, to develop and validate an in-house high-performance liquid chromatography tandem mass spectrometry (LC-MS/MS) assay for measuring plasma lenvatinib levels in patients with radioiodine refractory thyroid cancer. Patient data including dosage, TRAEs, and disease progression were recorded. Lenvatinib doses ranged between 4 mg to 14 mg daily. Trough and peak levels were measured in nine and eight patients respectively. Duration of treatment ranged from 7 to 63 months (mean 29 months), with treatment duration at the time of testing ranging from 1 to 14 months. Trough levels ranged from 4.60 to 30.53 µg/L (median 21.74 µg/L). Peak levels for patients receiving 10 mg (<i>n</i> = 3) ranged from 78.50 to 237.72 µg/L (median 129.56 µg/L), while those receiving 14 mg (<i>n</i> = 4) ranged from 65.10 to 263.64 µg/L (median 185.23 µg/L). Our study describes the successful development of a novel LC-MS/MS assay for quantifying plasma lenvatinib levels. Despite consistent dosing, we observed considerable variability in levels in this group. Further research is required to examine the utility of lenvatinib drug monitoring in the setting of thyroid cancer.
DOI: 10.25549/inscriptifact-ouc110856276
title: Persepolis Fortification Anepigraphic Tablet 0376.203, PFAnep 0376.203

description: [Text Description:] Administrative tablet with seals ❧ [Text or Publication Number Note:] PFAnep 0376.203, PFUT 0376-203 ❧ [Excavation Description:] Found during Oriental Institute's excavations in Spring, 1933, near the northeastern corner of the stone platform of Persepolis, in two small rooms of a bastion in the fortification wall ❧ [Medium:] Clay ❧ [Script Note:] Non-Text ❧ [Physical Object Description:] Clay tablet with seal impressions on bottom edge, obverse, reverse, upper edge. ❧ [Physical Object Note:] Damage or deposits on obverse, reverse.
DOI: 10.25549/inscriptifact-ouc110857056
title: Persepolis Fortification Anepigraphic Tablet 0377.203, PFAnep 0377.203

description: [Text Description:] Administrative tablet with seals ❧ [Text or Publication Number Note:] PFAnep 0377.203, PFUT 0377-203 ❧ [Excavation Description:] Found during Oriental Institute's excavations in Spring, 1933, near the northeastern corner of the stone platform of Persepolis, in two small rooms of a bastion in the fortification wall ❧ [Medium:] Clay ❧ [Script Note:] Non-Text ❧ [Physical Object Description:] Clay tablet with seal impressions on bottom edge, left edge, obverse, reverse, upper edge. ❧ [Physical Object Note:] Minor cracking. Small gouges on reverse.
DOI: 10.25549/inscriptifact-ouc110861365
title: Persepolis Fortification Anepigraphic Tablet 0383.204, PFAnep 0383.204

description: [Text Description:] Administrative tablet with seals ❧ [Text or Publication Number Note:] PFAnep 0383.204, PFUT 0383-204 ❧ [Excavation Description:] Found during Oriental Institute's excavations in Spring, 1933, near the northeastern corner of the stone platform of Persepolis, in two small rooms of a bastion in the fortification wall ❧ [Medium:] Clay ❧ [Script Note:] Non-Text ❧ [Physical Object Description:] Clay tablet with seal impressions on left edge, reverse? upper edge. ❧ [Physical Object Note:] Cracks on obverse and reverse. Other damage on reverse. (Upper and bottom edges may be reversed)
DOI: 10.25549/inscriptifact-ouc110857057
title: Persepolis Fortification Anepigraphic Tablet 0377.203, PFAnep 0377.203

description: [Text Description:] Administrative tablet with seals ❧ [Text or Publication Number Note:] PFAnep 0377.203, PFUT 0377-203 ❧ [Excavation Description:] Found during Oriental Institute's excavations in Spring, 1933, near the northeastern corner of the stone platform of Persepolis, in two small rooms of a bastion in the fortification wall ❧ [Medium:] Clay ❧ [Script Note:] Non-Text ❧ [Physical Object Description:] Clay tablet with seal impressions on bottom edge, left edge, obverse, reverse, upper edge. ❧ [Physical Object Note:] Minor cracking. Small gouges on reverse.
DOI: 10.25549/inscriptifact-ouc110861360
title: Persepolis Fortification Anepigraphic Tablet 0383.204, PFAnep 0383.204

description: [Text Description:] Administrative tablet with seals ❧ [Text or Publication Number Note:] PFAnep 0383.204, PFUT 0383-204 ❧ [Excavation Description:] Found during Oriental Institute's excavations in Spring, 1933, near the northeastern corner of the stone platform of Persepolis, in two small rooms of a bastion in the fortification wall ❧ [Medium:] Clay ❧ [Script Note:] Non-Text ❧ [Physical Object Description:] Clay tablet with seal impressions on left edge, reverse? upper edge. ❧ [Physical Object Note:] Cracks on obverse and reverse. Other damage on reverse. (Upper and bottom edges may be reversed)
DOI: 10.25549/inscriptifact-ouc110857050
title: Persepolis Fortification Anepigraphic Tablet 0377.203, PFAnep 0377.203

description: [Text Description:] Administrative tablet with seals ❧ [Text or Publication Number Note:] PFAnep 0377.203, PFUT 0377-203 ❧ [Excavation Description:] Found during Oriental Institute's excavations in Spring, 1933, near the northeastern corner of the stone platform of Persepolis, in two small rooms of a bastion in the fortification wall ❧ [Medium:] Clay ❧ [Script Note:] Non-Text ❧ [Physical Object Description:] Clay tablet with seal impressions on bottom edge, left edge, obverse, reverse, upper edge. ❧ [Physical Object Note:] Minor cracking. Small gouges on reverse.
DOI: 10.25549/inscriptifact-ouc110861357
title: Persepolis Fortification Anepigraphic Tablet 0383.204, PFAnep 0383.204

description: [Text Description:] Administrative tablet with seals ❧ [Text or Publication Number Note:] PFAnep 0383.204, PFUT 0383-204 ❧ [Excavation Description:] Found during Oriental Institute's excavations in Spring, 1933, near the northeastern corner of the stone platform of Persepolis, in two small rooms of a bastion in the fortification wall ❧ [Medium:] Clay ❧ [Script Note:] Non-Text ❧ [Physical Object Description:] Clay tablet with seal impressions on left edge, reverse? upper edge. ❧ [Physical Object Note:] Cracks on obverse and reverse. Other damage on reverse. (Upper and bottom edges may be reversed)
DOI: 10.25549/inscriptifact-ouc110857547
title: Persepolis Fortification Anepigraphic Tablet 0377.204, PFAnep 0377.204

description: [Text Description:] Administrative tablet with seals ❧ [Text or Publication Number Note:] PFAnep 0377.204, PFUT 0377-204 ❧ [Excavation Description:] Found during Oriental Institute's excavations in Spring, 1933, near the northeastern corner of the stone platform of Persepolis, in two small rooms of a bastion in the fortification wall ❧ [Medium:] Clay ❧ [Script Note:] Non-Text ❧ [Physical Object Description:] Clay tablet with seal impressions on left edge, obverse, reverse.
DOI: 10.25549/inscriptifact-ouc110861356
title: Persepolis Fortification Anepigraphic Tablet 0383.204, PFAnep 0383.204

description: [Text Description:] Administrative tablet with seals ❧ [Text or Publication Number Note:] PFAnep 0383.204, PFUT 0383-204 ❧ [Excavation Description:] Found during Oriental Institute's excavations in Spring, 1933, near the northeastern corner of the stone platform of Persepolis, in two small rooms of a bastion in the fortification wall ❧ [Medium:] Clay ❧ [Script Note:] Non-Text ❧ [Physical Object Description:] Clay tablet with seal impressions on left edge, reverse? upper edge. ❧ [Physical Object Note:] Cracks on obverse and reverse. Other damage on reverse. (Upper and bottom edges may be reversed)
DOI: 10.25549/inscriptifact-ouc110857543
title: Persepolis Fortification Anepigraphic Tablet 0377.204, PFAnep 0377.204

description: [Text Description:] Administrative tablet with seals ❧ [Text or Publication Number Note:] PFAnep 0377.204, PFUT 0377-204 ❧ [Excavation Description:] Found during Oriental Institute's excavations in Spring, 1933, near the northeastern corner of the stone platform of Persepolis, in two small rooms of a bastion in the fortification wall ❧ [Medium:] Clay ❧ [Script Note:] Non-Text ❧ [Physical Object Description:] Clay tablet with seal impressions on left edge, obverse, reverse.
DOI: 10.25549/inscriptifact-ouc110861350
title: Persepolis Fortification Anepigraphic Tablet 0383.204, PFAnep 0383.204

description: [Text Description:] Administrative tablet with seals ❧ [Text or Publication Number Note:] PFAnep 0383.204, PFUT 0383-204 ❧ [Excavation Description:] Found during Oriental Institute's excavations in Spring, 1933, near the northeastern corner of the stone platform of Persepolis, in two small rooms of a bastion in the fortification wall ❧ [Medium:] Clay ❧ [Script Note:] Non-Text ❧ [Physical Object Description:] Clay tablet with seal impressions on left edge, reverse? upper edge. ❧ [Physical Object Note:] Cracks on obverse and reverse. Other damage on reverse. (Upper and bottom edges may be reversed)
DOI: 10.25549/inscriptifact-ouc110857521
title: Persepolis Fortification Anepigraphic Tablet 0377.204, PFAnep 0377.204

description: [Text Description:] Administrative tablet with seals ❧ [Text or Publication Number Note:] PFAnep 0377.204, PFUT 0377-204 ❧ [Excavation Description:] Found during Oriental Institute's excavations in Spring, 1933, near the northeastern corner of the stone platform of Persepolis, in two small rooms of a bastion in the fortification wall ❧ [Medium:] Clay ❧ [Script Note:] Non-Text ❧ [Physical Object Description:] Clay tablet with seal impressions on left edge, obverse, reverse.
DOI: 10.25549/inscriptifact-ouc110857541
title: Persepolis Fortification Anepigraphic Tablet 0377.204, PFAnep 0377.204

description: [Text Description:] Administrative tablet with seals ❧ [Text or Publication Number Note:] PFAnep 0377.204, PFUT 0377-204 ❧ [Excavation Description:] Found during Oriental Institute's excavations in Spring, 1933, near the northeastern corner of the stone platform of Persepolis, in two small rooms of a bastion in the fortification wall ❧ [Medium:] Clay ❧ [Script Note:] Non-Text ❧ [Physical Object Description:] Clay tablet with seal impressions on left edge, obverse, reverse.
DOI: 10.25549/inscriptifact-ouc110857442
title: Persepolis Fortification Anepigraphic Tablet 0377.204, PFAnep 0377.204

description: [Text Description:] Administrative tablet with seals ❧ [Text or Publication Number Note:] PFAnep 0377.204, PFUT 0377-204 ❧ [Excavation Description:] Found during Oriental Institute's excavations in Spring, 1933, near the northeastern corner of the stone platform of Persepolis, in two small rooms of a bastion in the fortification wall ❧ [Medium:] Clay ❧ [Script Note:] Non-Text ❧ [Physical Object Description:] Clay tablet with seal impressions on left edge, obverse, reverse.
DOI: 10.25549/inscriptifact-ouc110857536
title: Persepolis Fortification Anepigraphic Tablet 0377.204, PFAnep 0377.204

description: [Text Description:] Administrative tablet with seals ❧ [Text or Publication Number Note:] PFAnep 0377.204, PFUT 0377-204 ❧ [Excavation Description:] Found during Oriental Institute's excavations in Spring, 1933, near the northeastern corner of the stone platform of Persepolis, in two small rooms of a bastion in the fortification wall ❧ [Medium:] Clay ❧ [Script Note:] Non-Text ❧ [Physical Object Description:] Clay tablet with seal impressions on left edge, obverse, reverse.
DOI: 10.25549/inscriptifact-ouc110857436
title: Persepolis Fortification Anepigraphic Tablet 0377.204, PFAnep 0377.204

description: [Text Description:] Administrative tablet with seals ❧ [Text or Publication Number Note:] PFAnep 0377.204, PFUT 0377-204 ❧ [Excavation Description:] Found during Oriental Institute's excavations in Spring, 1933, near the northeastern corner of the stone platform of Persepolis, in two small rooms of a bastion in the fortification wall ❧ [Medium:] Clay ❧ [Script Note:] Non-Text ❧ [Physical Object Description:] Clay tablet with seal impressions on left edge, obverse, reverse.
DOI: 10.25549/inscriptifact-ouc110857519
title: Persepolis Fortification Anepigraphic Tablet 0377.204, PFAnep 0377.204

description: [Text Description:] Administrative tablet with seals ❧ [Text or Publication Number Note:] PFAnep 0377.204, PFUT 0377-204 ❧ [Excavation Description:] Found during Oriental Institute's excavations in Spring, 1933, near the northeastern corner of the stone platform of Persepolis, in two small rooms of a bastion in the fortification wall ❧ [Medium:] Clay ❧ [Script Note:] Non-Text ❧ [Physical Object Description:] Clay tablet with seal impressions on left edge, obverse, reverse.
DOI: 10.25549/inscriptifact-ouc110856180
title: Persepolis Fortification Anepigraphic Tablet 0376.203, PFAnep 0376.203

description: [Text Description:] Administrative tablet with seals ❧ [Text or Publication Number Note:] PFAnep 0376.203, PFUT 0376-203 ❧ [Excavation Description:] Found during Oriental Institute's excavations in Spring, 1933, near the northeastern corner of the stone platform of Persepolis, in two small rooms of a bastion in the fortification wall ❧ [Medium:] Clay ❧ [Script Note:] Non-Text ❧ [Physical Object Description:] Clay tablet with seal impressions on bottom edge, obverse, reverse, upper edge. ❧ [Physical Object Note:] Damage or deposits on obverse, reverse.
DOI: 10.25549/inscriptifact-ouc110857416
title: Persepolis Fortification Anepigraphic Tablet 0377.204, PFAnep 0377.204

description: [Text Description:] Administrative tablet with seals ❧ [Text or Publication Number Note:] PFAnep 0377.204, PFUT 0377-204 ❧ [Excavation Description:] Found during Oriental Institute's excavations in Spring, 1933, near the northeastern corner of the stone platform of Persepolis, in two small rooms of a bastion in the fortification wall ❧ [Medium:] Clay ❧ [Script Note:] Non-Text ❧ [Physical Object Description:] Clay tablet with seal impressions on left edge, obverse, reverse.
DOI: 10.25549/inscriptifact-ouc110857405
title: Persepolis Fortification Anepigraphic Tablet 0377.204, PFAnep 0377.204

description: [Text Description:] Administrative tablet with seals ❧ [Text or Publication Number Note:] PFAnep 0377.204, PFUT 0377-204 ❧ [Excavation Description:] Found during Oriental Institute's excavations in Spring, 1933, near the northeastern corner of the stone platform of Persepolis, in two small rooms of a bastion in the fortification wall ❧ [Medium:] Clay ❧ [Script Note:] Non-Text ❧ [Physical Object Description:] Clay tablet with seal impressions on left edge, obverse, reverse.
DOI: 10.25549/inscriptifact-ouc110856175
title: Persepolis Fortification Anepigraphic Tablet 0376.203, PFAnep 0376.203

description: [Text Description:] Administrative tablet with seals ❧ [Text or Publication Number Note:] PFAnep 0376.203, PFUT 0376-203 ❧ [Excavation Description:] Found during Oriental Institute's excavations in Spring, 1933, near the northeastern corner of the stone platform of Persepolis, in two small rooms of a bastion in the fortification wall ❧ [Medium:] Clay ❧ [Script Note:] Non-Text ❧ [Physical Object Description:] Clay tablet with seal impressions on bottom edge, obverse, reverse, upper edge. ❧ [Physical Object Note:] Damage or deposits on obverse, reverse.
DOI: 10.25549/inscriptifact-ouc110856502
title: Persepolis Fortification Anepigraphic Tablet 0376.203, PFAnep 0376.203

description: [Text Description:] Administrative tablet with seals ❧ [Text or Publication Number Note:] PFAnep 0376.203, PFUT 0376-203 ❧ [Excavation Description:] Found during Oriental Institute's excavations in Spring, 1933, near the northeastern corner of the stone platform of Persepolis, in two small rooms of a bastion in the fortification wall ❧ [Medium:] Clay ❧ [Script Note:] Non-Text ❧ [Physical Object Description:] Clay tablet with seal impressions on bottom edge, obverse, reverse, upper edge. ❧ [Physical Object Note:] Damage or deposits on obverse, reverse.
DOI: 10.25549/inscriptifact-ouc110856167
title: Persepolis Fortification Anepigraphic Tablet 0376.203, PFAnep 0376.203

description: [Text Description:] Administrative tablet with seals ❧ [Text or Publication Number Note:] PFAnep 0376.203, PFUT 0376-203 ❧ [Excavation Description:] Found during Oriental Institute's excavations in Spring, 1933, near the northeastern corner of the stone platform of Persepolis, in two small rooms of a bastion in the fortification wall ❧ [Medium:] Clay ❧ [Script Note:] Non-Text ❧ [Physical Object Description:] Clay tablet with seal impressions on bottom edge, obverse, reverse, upper edge. ❧ [Physical Object Note:] Damage or deposits on obverse, reverse.
DOI: 10.25549/inscriptifact-ouc110856500
title: Persepolis Fortification Anepigraphic Tablet 0376.203, PFAnep 0376.203

description: [Text Description:] Administrative tablet with seals ❧ [Text or Publication Number Note:] PFAnep 0376.203, PFUT 0376-203 ❧ [Excavation Description:] Found during Oriental Institute's excavations in Spring, 1933, near the northeastern corner of the stone platform of Persepolis, in two small rooms of a bastion in the fortification wall ❧ [Medium:] Clay ❧ [Script Note:] Non-Text ❧ [Physical Object Description:] Clay tablet with seal impressions on bottom edge, obverse, reverse, upper edge. ❧ [Physical Object Note:] Damage or deposits on obverse, reverse.
DOI: 10.15156/bio/sh1408020.10fu
title: SH1408020.10FU

description: UNITE provides a unified way for delimiting, identifying, communicating, and working with DNA-based Species Hypotheses (SH). All fungal ITS sequences in the international nucleotide sequence databases are clustered to approximately the species level by applying a set of dynamic distance values (<0.5 - 3.0%). All species hypotheses are given a unique, stable name in the form of a DOI, and their taxonomic and ecological annotations are verified through distributed, web-based third-party annotation efforts. SHs are connected to a taxon name and its classification as far as possible (phylum, class, order, etc.) by taking into account identifications for all sequences in the SH. An automatically or manually designated sequence is chosen to represent each such SH. These sequences are released (https://unite.ut.ee/repository.php) for use by the scientific community in, for example, local sequence similarity searches and next-generation sequencing analysis pipelines. The system and the data are updated automatically as the number of public fungal ITS sequences grows.
DOI: 10.15156/bio/sh1408021.10fu
title: SH1408021.10FU

description: UNITE provides a unified way for delimiting, identifying, communicating, and working with DNA-based Species Hypotheses (SH). All fungal ITS sequences in the international nucleotide sequence databases are clustered to approximately the species level by applying a set of dynamic distance values (<0.5 - 3.0%). All species hypotheses are given a unique, stable name in the form of a DOI, and their taxonomic and ecological annotations are verified through distributed, web-based third-party annotation efforts. SHs are connected to a taxon name and its classification as far as possible (phylum, class, order, etc.) by taking into account identifications for all sequences in the SH. An automatically or manually designated sequence is chosen to represent each such SH. These sequences are released (https://unite.ut.ee/repository.php) for use by the scientific community in, for example, local sequence similarity searches and next-generation sequencing analysis pipelines. The system and the data are updated automatically as the number of public fungal ITS sequences grows.
DOI: 10.15468/dl.ybygkx
title: Occurrence Download

description: A dataset containing 27794 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Syngonanthus"
 ]
}

 The dataset includes 27794 records from 370 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0006243-260108223611665/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.mgr48h
title: Occurrence Download

description: A dataset listing the 2 species recorded in GBIF matching the query:
{
 "and" : [
 "Continent is Asia",
 "Country is China",
 "TaxonKey is Cylindrospermopsis"
 ]
}

 The dataset's 2 records were derived from 2 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0006236-260108223611665/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15156/bio/sh1408027.10fu
title: SH1408027.10FU

description: UNITE provides a unified way for delimiting, identifying, communicating, and working with DNA-based Species Hypotheses (SH). All fungal ITS sequences in the international nucleotide sequence databases are clustered to approximately the species level by applying a set of dynamic distance values (<0.5 - 3.0%). All species hypotheses are given a unique, stable name in the form of a DOI, and their taxonomic and ecological annotations are verified through distributed, web-based third-party annotation efforts. SHs are connected to a taxon name and its classification as far as possible (phylum, class, order, etc.) by taking into account identifications for all sequences in the SH. An automatically or manually designated sequence is chosen to represent each such SH. These sequences are released (https://unite.ut.ee/repository.php) for use by the scientific community in, for example, local sequence similarity searches and next-generation sequencing analysis pipelines. The system and the data are updated automatically as the number of public fungal ITS sequences grows.