cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.3535/xvr-5cz-vcz
title: Elaphroconcha bataviana (L. Pfeiffer, 1842)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/238-flg-e9e
title: Cepaea nemoralis (Linnaeus, 1758)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/7rx-ejz-0v2
title: Arcidae Lamarck, 1809

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/stp-7ty-sgs
title: Saccella eburnea (G. B. Sowerby I, 1833)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.5281/zenodo.16795420
title: Presence-Absence grids for >6000 invertebrate species in Europe

description: Species presence-absence grids for 6844 invertebrate species in Europe belonging to 13 different taxonomic groups (Collembola, Gastropoda, Araneae, Crassiclitellata, Orthoptera, Formicidae, Syrphidae, Anthophila (Hymenoptera), Heterocera (Lepidoptera), Rhopalocera (Lepidoptera), Odonata, Ichneumonoidea (Hymenoptera), Carabidae). Group level sampling effort layers are also provided.
DOI: 10.5281/zenodo.16795421
title: Presence-Absence grids for >6000 invertebrate species in Europe

description: Species presence-absence grids for 6844 invertebrate species in Europe belonging to 13 different taxonomic groups (Collembola, Gastropoda, Araneae, Crassiclitellata, Orthoptera, Formicidae, Syrphidae, Anthophila (Hymenoptera), Heterocera (Lepidoptera), Rhopalocera (Lepidoptera), Odonata, Ichneumonoidea (Hymenoptera), Carabidae). Group level sampling effort layers are also provided.
DOI: 10.3535/2yp-e93-xkt
title: Euomphalia strigella (Draparnaud, 1801)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/k8w-djh-s3g
title: Austronucula perminima (Monterosato, 1875)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/1kg-8nn-ka6
title: Austrochloritis brevipila (L. Pfeiffer, 1849)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/33f-vj5-h65
title: Xerotricha conspurcata (Draparnaud, 1801)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/wmf-0rk-stg
title: Brachidontes exustus (Linnaeus, 1758)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/kvg-w5g-4d3
title: Elliptio arctata (Conrad, 1834)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/s43-7p5-gkc
title: Anadara antiquata (Linnaeus, 1758)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/15j-x1x-lsf
title: Dentellaria bronni (L. Pfeiffer, 1846)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/qhb-m7n-3lz
title: Aegopis croaticus (A. Férussac, 1832)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/6et-1ve-h6h
title: Codakia orbicularis (Linnaeus, 1758)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/sns-wef-9hh
title: Ferussacia Risso, 1826

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/qp1-a9q-qww
title: Caribachlamys pellucens (Linnaeus, 1758)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/6v2-ej1-dm1
title: Cepaea nemoralis (Linnaeus, 1758)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/dr3-kfn-x4t
title: Spondylus foliaceus Schreibers, 1793

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/62q-h8j-8xh
title: Cochlicella acuta (O. F. Müller, 1774)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/pr8-21v-xxr
title: Lindholmiola lens (A. Férussac, 1832)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/jg9-x54-tnj
title: Conus glans Hwass, 1792

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/n30-0fq-eel
title: Glycymeris glycymeris (Linnaeus, 1758)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/mvn-q7j-d93
title: Lampsilis cardium Rafinesque, 1820

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/3ja-4lh-3wy
title: Anomia ephippium Linnaeus, 1758

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/lgp-q04-9n7
title: Cerion striatellum (Guerin-Méneville, 1829)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/v4f-alk-qgn
title: Cepaea nemoralis (Linnaeus, 1758)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/9gh-w2b-8ce
title: Gonyodiscus rotundatus (O. F. Müller, 1774)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/p41-74x-zcs
title: Cernuella virgata (Da Costa, 1778)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/3a7-xfm-9ez
title: Loripes orbiculatus Poli, 1795

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/czx-x0y-cwc
title: Chrysallis aspersa (Grateloup, 1840)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/1jq-54j-q4w
title: Sphaerospira Mörch, 1867

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/z6p-j3f-dqz
title: Cardiolucina semperiana (Issel, 1869)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/fa9-9xd-erw
title: Barbatia trapezina (Lamarck, 1819)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/kf6-gn6-0dv
title: Anadara rufescens (Reeve, 1844)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/qn9-at8-c5a
title: Unio tumidus Philipsson, 1788

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/xgp-ja0-d6j
title: Elliptio spinosa (I. Lea, 1836)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/xvp-ab8-fjd
title: Anadara rufescens (Reeve, 1844)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/26a-85d-364
title: Striarca lactea (Linnaeus, 1758)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/3y9-a8r-pd1
title: Amphidromus Albers, 1850

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/28e-4mp-de5
title: Unio tumidus Philipsson, 1788

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/4hj-zml-mpn
title: Hemiplecta humphreysiana (I. Lea, 1840)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/hpp-g3f-zr5
title: Papuina hermione (Angas, 1870)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/7q6-pan-ptg
title: Spondylus squamosus Schreibers, 1793

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/v5n-8xe-smt
title: Alasmidonta heterodon (I. Lea, 1829)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/49d-d4d-kz9
title: Caracollina lenticula (Michaud, 1831)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/bff-m71-gka
title: Ampelita H. Beck, 1837

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/9ha-fdd-1nj
title: Cecilioides acicula (O. F. Müller, 1774)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/ghf-kjy-cs0
title: Xerolenta obvia (Menke, 1828)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/yh5-s9q-w54
title: Aegopinella pura (Alder, 1830)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/zde-6tq-9tt
title: Euconulus fulvus (O. F. Müller, 1774)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/mvd-z20-pe9
title: Theba geminata (Mousson, 1857)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/4gv-wrs-vgn
title: Conus capitaneus Linnaeus, 1758

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/k1r-jpq-wym
title: Satsuma succincta (H. Adams, 1866)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/knm-plg-phl
title: Monacha Fitzinger, 1833

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/9c3-djs-7gd
title: Acar plicata (Dillwyn, 1817)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/dka-9q3-53z
title: Ligumia recta (Lamarck, 1819)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/2zk-pcv-v7h
title: Helicidae Rafinesque, 1815

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/km2-9pj-eeg
title: Vulsella fornicata (Forsskål, 1775)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/efh-l08-bzb
title: Trochomorpha kantavuensis Garrett, 1887

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/ej4-jjx-kqb
title: Mastigophallus rangianus (Michaud, 1831)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/cgm-bad-jh7
title: †Leptaxis chrysomela (L. Pfeiffer, 1846)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/6wk-v9z-0zr
title: Cernuella virgata (Da Costa, 1778)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/npz-gj2-anm
title: Dinarica pouzolzii (Deshayes, 1832)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.15468/dl.mabqyq
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is Indonesia",
 "HasCoordinate is TRUE",
 "TaxonKey is one of (Ambystoma maculatum, Ambystoma mexicanum, Pseudotriton ruber, Salamandra salamandra)"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0004746-250811113504898/datasets/export for details.
DOI: 10.3535/0pz-kwn-sqk
title: Plagioptycha macroglossa (L. Pfeiffer, 1866)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/pks-gtl-k8w
title: Monacha messenica (Blanc, 1879)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/g9v-cqz-5g0
title: Isognomostoma isognomostomos (Schröter, 1784)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/pqt-vvy-g18
title: Caracolus sagemon (H. Beck, 1837)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/028-al2-exa
title: Anadara notabilis (Röding, 1798)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/bj9-xsg-raq
title: Pinctada margaritifera (Linnaeus, 1758)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/svv-j64-my5
title: Ctena bella (Conrad, 1837)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/c4c-w70-ybt
title: Papuina multizona (Lesson, 1831)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/wk8-2m9-xfm
title: Barbatia barbata (Linnaeus, 1758)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/cvc-wew-hdm
title: Lima vulgaris (Link, 1807)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/dss-xve-r8d
title: Hyriopsis myersiana (I. Lea, 1856)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/n1q-hfy-dqq
title: Jolya arata (Dunker, 1857)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/h02-ly5-312
title: Soosia P. Hesse, 1918

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/lfq-tfn-8xc
title: Pfeifferia micans (L. Pfeiffer, 1845)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/lb4-5pz-cgs
title: Perpolita hammonis (Strøm, 1765)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/4r6-tyh-5rv
title: Allopeas gracile (T. Hutton, 1834)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/cyw-5k7-2ww
title: Oreohelix subrudis (Reeve, 1854)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/ah7-y4m-p9e
title: Metafruticicola Ihering, 1892

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/c9g-0ma-gnk
title: Polymita picta (Born, 1778)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/pjy-904-q06
title: Xerolenta obvia (Menke, 1828)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/d8x-ak0-h72
title: Caracollina lenticula (Michaud, 1831)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/ls5-k5x-0xb
title: Yoldiella philippiana (Nyst, 1845)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/5nx-s2v-z4m
title: Eurycampta E. von Martens, 1860

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/fhs-lz3-xl6
title: Rumina decollata (Linnaeus, 1758)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/917-f3r-y3y
title: Limaria orientalis (A. Adams & Reeve, 1850)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/edt-92v-c2b
title: Hamiota australis (C. T. Simpson, 1900)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/ct3-jpg-yg5
title: Helix pomatia Linnaeus, 1758

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/g8p-a9g-nxy
title: Perna perna (Linnaeus, 1758)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/qng-j0a-q9d
title: Modiolus americanus Leach, 1815

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/vnb-wdv-vzx
title: Monacha obstructa (L. Pfeiffer, 1842)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/w79-447-f3b
title: Microxeromagna lowei (Potiez & Michaud, 1838)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/5k6-lld-f0a
title: Coryda Albers, 1850

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/b4n-vvl-c32
title: Pyrochilus pyrostoma (A. Férussac, 1821)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/db7-4x7-316
title: Rectartemon candidus (Spix, 1827)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/2cc-kmn-s7h
title: Ctena bella (Conrad, 1837)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/5zz-x76-mls
title: Allopeas gracile (T. Hutton, 1834)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.15468/dl.ye6pa9
title: Occurrence Download

description: A dataset containing 491 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Chlamydotis undulata",
 "MediaType is Image"
 ]
}

 The dataset includes 491 records from 12 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0004744-250811113504898/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.3535/ehd-sjp-7zp
title: Fissurisepta granulosa Jeffreys, 1883

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/8t8-qez-rae
title: Helicidae Rafinesque, 1815

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/m7s-pnq-he8
title: Cardiolucina semperiana (Issel, 1869)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/s1z-ped-f89
title: Limatula maoria H. J. Finlay, 1926

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/azc-ler-bay
title: Barbatia candida (Helbling, 1779)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/hw5-clg-kxa
title: Modiolus Lamarck, 1799

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/m1v-y8c-780
title: Caracolus marginella (Gmelin, 1791)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/q0m-yx7-s11
title: Hemiglyptopsis fouillioyi (Le Guillou, 1845)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/8wr-8q1-3gb
title: Arcopsis adamsi (Dall, 1886)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/lty-3lj-cg7
title: Rhynchotrochus taylorianus (A. Adams & Reeve, 1850)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/tvs-gjt-s2p
title: Solaropsis undata ([Lightfoot], 1786)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/4qf-aly-zf3
title: Theba pisana (O. F. Müller, 1774)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/tbx-ge8-2kb
title: Labyrinthus raimondii (R. A. Philippi, 1867)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/004-8rr-b8f
title: Chilostoma millieri (Bourguignat, 1880)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/54q-lvh-0z3
title: Cochlostyla velata (Broderip, 1841)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/93f-p07-8bv
title: Nucula sulcata Bronn, 1831

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/baf-vvd-jdn
title: Hemitrochus varians (Menke, 1829)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/wy7-l48-wnk
title: Rhagada radleyi Preston, 1908

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/sq2-mg4-j4x
title: Conus cancellatus Hwass, 1792

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/ww9-k3k-wgn
title: Bathyarca philippiana (Nyst, 1848)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/nv1-cle-mzt
title: Crystallopsis Ancey, 1887

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/tvp-y6x-400
title: Geukensia demissa (Dillwyn, 1817)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.5281/zenodo.16835187
title: Molecular Insights into the Binding Specificity of Branched-Chain Amino Acids to Sestrin2: An Integrated Computational Study Using Molecular Docking, MD Simulations, and MMGBSA Analysis

description: Sestrin2 (SESN2) is a highly conserved stress-inducible protein that serves as a central hub for integrating cellular responses to nutrient availability, oxidative stress, and endoplasmic reticulum (ER) stress. A key function of SESN2 is its role as a direct sensor for the branched-chain amino acid (BCAA) leucine, which modulates the activity of the mechanistic target of rapamycin complex 1 (mTORC1), a master regulator of cell growth and metabolism. While the functional link between leucine and SESN2 is well-established, the precise molecular determinants that confer its high specificity for leucine over other BCAAs, such as isoleucine and valine, remain poorly understood. This study employs an integrated, multi-scale computational approach, combining molecular docking, extensive all-atom molecular dynamics (MD) simulations, and binding free energy calculations, to elucidate the structural and dynamic basis of BCAA-SESN2 recognition. Our thermodynamic analysis reveals a distinct binding affinity hierarchy (Leucine > Isoleucine > Valine), which is primarily driven by superior van der Waals interactions and shape complementarity of leucine's isobutyl side chain within the protein's hydrophobic pocket. Structural and dynamic analyses demonstrate that leucine binding induces a profound allosteric stabilization, causing a global compaction of the protein and establishing a network of long-range correlated motions. This "conformational locking" mechanism funnels the intrinsically flexible apo-protein into a singular, stable, low-energy state. These findings provide a comprehensive, atom-to-global scale model explaining SESN2's function as a specific leucine sensor. Furthermore, by contextualizing these results within the broader landscape of SESN2's mTORC1-independent functions and recent clinical trial outcomes for SESN2 modulators, this work offers a critical framework for understanding its complex role in metabolic diseases, cancer, and neurodegeneration, and provides a rationale for the design of next-generation allosteric therapeutics.