cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.17632/pjcngm8b8w.1
title: Endocrine Fellowship Online Survey Distributed to Participants

description: Objectives: There is a current and anticipated labor shortage of endocrinologists in the United States. Over the past decade, the number of applications to endocrinology fellowship programs has plateaued despite increased available positions, and interest in endocrinology has declined relative to other internal medicine sub-specialty fields. The examination of driving factors for pursuing endocrinology as a subspecialty career is needed.  

Methods: A 12-question online survey was developed to identify the primary reasons for current endocrinology fellows/trainees to pursue the field. This survey was sent to 152 U.S. endocrinology fellowship program directors for completion by their fellows between July and August 2021. 

Results: A total of 176 of 629 fellows (28.0%) completed the survey. The majority (57.4%) had decided to pursue endocrinology as a career during residency, whereas 27.3% had decided during medical school. There were 79 fellows (44.9%) who ranked their endocrinology rotation during residency as the most influential factor, followed by positive experiences with a clinical mentor (27.3%). Endocrinology exposure during medical school was sparse, with only 2.8% noting the availability of an endocrinology student interest group, while 59.7% reported inadequate endocrinology exposure during their medical school curriculum.

Conclusions: The majority of current endocrinology fellows/trainees report that exposure to the field during medical school was limited, and that their endocrinology elective and mentorship experiences during residency were the most influential factors for pursuing endocrinology as a subspecialty. Improved integration of endocrinology experiences between medical school and residency may enhance career interest in endocrinology.
DOI: 10.17632/c58ngv5mm7.1
title: Germinal center responses to SARS-CoV-2 mRNA vaccines in healthy and immunocompromised individuals. Lederer et al.

description: Supplementary Table 4. Cell populations from FNA and PBMC samples, related to Figures 1-5 and S1-6.
Data are displayed as a percentage of lymphocytes.
DOI: 10.5281/zenodo.3711720
title: Dataset related to the article "Activation of Nrf2/HO-1 Pathway and Human Atherosclerotic Plaque Vulnerability: an In Vitro and In Vivo Study"

description: This record contains raw data related to the article “Activation of Nrf2/HO-1 Pathway and Human Atherosclerotic Plaque Vulnerability: an In Vitro and In Vivo Study" Abstract: Reactive oxygen species (ROS) induce nuclear factor erythroid 2–related factor 2 (Nrf2) activation as an adaptive defense mechanism, determining the synthesis of antioxidant molecules, including heme-oxygenase-1 (HO-1). HO-1 protects cells against oxidative injury, degrading free heme and inhibiting ROS production. HO-1 is highly expressed in macrophages during plaque growth. Macrophages are morpho-functionally heterogeneous, and the prevalence of a specific phenotype may influence the plaque fate. This heterogeneity has also been observed in monocyte-derived macrophages(MDMs), a model of macrophages infiltrating tissue. The study aims to assess oxidative stress status and Nrf2/HO-1 axis in MDM morphotypes obtained from healthy subjects and coronary artery disease (CAD) patients, in relation to coronary plaque features evaluated in vivo by optical coherence tomography (OCT). We found that MDMs of healthy subjects exhibited a lower oxidative stress status, lower Nrf2 and HO-1 levels as compared to CAD patients. High HO-1 levels in MDMs were associated with the presence of a higher macrophage content, a thinner fibrous cap, and a ruptured plaque with thrombus formation, detected by OCT analysis. These findings suggest the presence of a relationship between in vivo plaque characteristics and in vitro MDM profile, and may help to identify patients with rupture-prone coronary plaque.
description: This work was supported by the Italian Ministry of Health, Rome, Italy (Ricerca Corrente 2014: CC13; 2015: CC13; 2016: CC18). Co-funding provided by the contribution of the Italian "5×1000" tax (2010, 2011, 2012).
DOI: 10.5281/zenodo.3711719
title: Dataset related to the article "Activation of Nrf2/HO-1 Pathway and Human Atherosclerotic Plaque Vulnerability: an In Vitro and In Vivo Study"

description: This record contains raw data related to the article “Activation of Nrf2/HO-1 Pathway and Human Atherosclerotic Plaque Vulnerability: an In Vitro and In Vivo Study" Abstract: Reactive oxygen species (ROS) induce nuclear factor erythroid 2–related factor 2 (Nrf2) activation as an adaptive defense mechanism, determining the synthesis of antioxidant molecules, including heme-oxygenase-1 (HO-1). HO-1 protects cells against oxidative injury, degrading free heme and inhibiting ROS production. HO-1 is highly expressed in macrophages during plaque growth. Macrophages are morpho-functionally heterogeneous, and the prevalence of a specific phenotype may influence the plaque fate. This heterogeneity has also been observed in monocyte-derived macrophages(MDMs), a model of macrophages infiltrating tissue. The study aims to assess oxidative stress status and Nrf2/HO-1 axis in MDM morphotypes obtained from healthy subjects and coronary artery disease (CAD) patients, in relation to coronary plaque features evaluated in vivo by optical coherence tomography (OCT). We found that MDMs of healthy subjects exhibited a lower oxidative stress status, lower Nrf2 and HO-1 levels as compared to CAD patients. High HO-1 levels in MDMs were associated with the presence of a higher macrophage content, a thinner fibrous cap, and a ruptured plaque with thrombus formation, detected by OCT analysis. These findings suggest the presence of a relationship between in vivo plaque characteristics and in vitro MDM profile, and may help to identify patients with rupture-prone coronary plaque.
description: This work was supported by the Italian Ministry of Health, Rome, Italy (Ricerca Corrente 2014: CC13; 2015: CC13; 2016: CC18). Co-funding provided by the contribution of the Italian "5×1000" tax (2010, 2011, 2012).
DOI: 10.5281/zenodo.5931033
title: 20210601-DOTG: Knowledge is transmitted between agents and across generations

description: This archive contains the results of a multi-agent simulation experiment [1] carried out with Lazy lavender [2] environment.<br> <br> Experiment Label: 20210601-DOTG<br> <br> Experiment design: Knowledge is transmitted between agents and across generations<br> <br> Experiment setting: Agents start with random ontologies; agents adapt their knowledge to interaction failures with other agents (intra-generation knowledge transmission); agents provide training samples to their children to learn ontologies and interact with them (inter-generation knowledge transmission)<br> <br> Hypotheses: Adding inter-generation transmission leads to higher accuracy than intra-generation transmission alone<br> <br> Detailed information can be found in index.html or notebook.ipynb.<br> <br> [1] https://sake.re/20210601-DOTG<br> [2] https://gitlab.inria.fr/moex/lazylav/<br>
DOI: 10.5281/zenodo.5930302
title: 20210601-DOTG: Knowledge is transmitted between agents and across generations

description: This archive contains the results of a multi-agent simulation experiment [1] carried out with Lazy lavender [2] environment.<br> <br> Experiment Label: 20210601-DOTG<br> <br> Experiment design: Knowledge is transmitted between agents and across generations<br> <br> Experiment setting: Agents start with random ontologies; agents adapt their knowledge to interaction failures with other agents (intra-generation knowledge transmission); agents provide training samples to their children to learn ontologies and interact with them (inter-generation knowledge transmission)<br> <br> Hypotheses: Adding inter-generation transmission leads to higher accuracy than intra-generation transmission alone<br> <br> Detailed information can be found in index.html or notebook.ipynb.<br> <br> [1] https://sake.re/20210601-DOTG<br> [2] https://gitlab.inria.fr/moex/lazylav/<br>
DOI: 10.5519/qd.scjn9g77
title: Query on the Natural History Museum Data Portal (data.nhm.ac.uk) (1 records)
DOI: 10.17632/fkm3rjcspp.1
title: Dataset for Laser Scanning of Dadi-Poti Monument in New Delhi India

description: The point cloud data of the monument was collected in 2017 using the Terrestrial Laser Scanner for the dadi-poti tomb in New Delhi. The data shared is a subset of about 924 million points with values for coordinates (x, y, z) and the intensity of the returned signal. The original file format was LAS file, but for compatibility with python, it was converted to .PTX format using pointzip tool. To render all points on the computer at full resolution, the data was divided into 197 parts with the use of LAStools and the proper region will be selected accordingly. Out of 197 parts, select 11 parts are shared for interested readers. Five images are also provided with the point cloud data to help visualise the monument in reality.
DOI: 10.5281/zenodo.5930729
title: JACUSA2 - use cases: 1 - 3

description: <strong>Supplementary data</strong> for use cases presented in: RNA modification mapping with JACUSA2<br> Michael Piechotta, Qi Wang, Janine Altmüller, Christoph Dieterich<br> doi: https://doi.org/10.1101/2021.07.02.450888 <strong>Use case 1: m6A mapping by MazF</strong> MazF_vs_cond2_FTO_rtarrest_plain_result.out.gz (JACUSA2 output) Cutoff01_MazF_vs_cond2_FTO_rtarrest_plain_result.out.gz (filtered by pvalue &lt;=0.1) <strong>Use case 2: </strong><strong>DART-seq</strong> APOBEC1YTH_APOBEC1YTHmut_call2_result.out.gz (JACUSA2 output) <strong>Use case 3: Nanopore</strong> WT_vs_KO_call2_result.out.gz (JACUSA2 output) WT_vs_realIVT_v202_call2_result.out.gz (JACUSA2 output) [1] Zhang, Z., Chen, L.-Q., Zhao, Y.-L., Yang, C.-G., Roundtree, I.A., Zhang, Z., Ren, J., Xie, W., He, C., Luo, G.-Z.: Single-base mapping of m6a by an antibody-independent method. Science advances 5, 0250 (2019). doi:10.1126/sciadv.aax0250 [2] Garcia-Campos, M.A., Edelheit, S., Toth, U., Safra, M., Shachar, R., Viukov, S., Winkler, R., Nir, R., Lasman, L., Brandis, A., Hanna, J.H., Rossmanith, W., Schwartz, S.: Deciphering the ”m6a code” via antibody-independent quantitative profiling. Cell 178, 731–74716 (2019). doi:10.1016/j.cell.2019.06.013 [3] Meyer, K.D.: Dart-seq: an antibody-free method for global m6a detection. Nature methods 16, 1275–1280 (2019). doi:10.1038/s41592-019- 0570-0 [4] Pratanwanich, P.N., Yao, F., Chen, Y., Koh, C.W.Q., Hendra, C., Poon, P., Goh, Y.T., Yap, P.M.L., Yuan, C.J., Chng, 6 made available under aCC-BY-NC-ND 4.0 International license. (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is bioRxiv preprint doi: https://doi.org/10.1101/2021.07.02.450888; this version posted July 4, 2021. The copyright holder for this preprint W.J., Ng, S., Thiery, A., Goh, W.S.S., G¨oke, J.: Detection of differential rna modifications from direct rna sequencing of human cell lines. bioRxiv (2020). doi:10.1101/2020.06.18.160010. https://www.biorxiv.org/content/early/2020/06/20/2020.06.18.160010.full.pdf
DOI: 10.17632/twkkb6bmdv.1
title: Maxicircles_Linf-Bussotti_2018

description: This dataset contains 3 maxicircles sequences assembled from Illumina sequence reads; the sequencing of total DNA from this Leishmania infantum isolates was carried out by Bussotti et al. (2018.  mBio 9, e01399. PMID: 30401775). The assembling was done following the procedure described by Camacho et al (2019. Genes (Basel) 10, 758; PMID: 31561572). The maxicircle coding regions are indicated by upper letters in the sequences. The archive has fasta format (BioEdit). The WHO codes for the isolates are:
LLM1356, MCAN/ES/2004/LLM-1356; LLM1345, MCAN/ES/2004/LLM-1345; Linf_02A_EP, not found
DOI: 10.5281/zenodo.5930793
title: Data generated by the model presented in the research article entitled "Simulation of mass and heat transport processes in an evaporatively cooled proton exchange membrane fuel cell"

description: This repository provides all the data and scripts necessary to reproduce the line plots shown in the manuscript entitled "Simulation of mass and heat transport processes in an evaporatively cooled proton exchange membrane fuel cell".
description: The research leading to this data was funded by Swiss Federal Office of Energy SFOE grant number SI/501764-01 and by Swiss Competence Center for Energy Research—Efficient Technologies and Systems for Mobility (SCCER Mobility).
DOI: 10.17632/p7zv55hnd5.1
title: Experimental modelling of body schema with the rubber hand illusion and the hand laterality judgment task

description: The study sample included 31 (17 male) right-handed healthy volunteers aged 18–35 (mean 20.5±3) years, who took part in the Rubber Hand Illusion and Hand Laterality Judgment Task.
Detailed description of the experiments can be found in the preprint at http://dx.doi.org/10.13140/RG.2.2.31010.91849
DOI: 10.17632/vx2xmjgmk9.3
title: Data to "Functional control of a 0.5 MDa TET aminopeptidase by a flexible loop revealed by MAS NMR"

description: This data set is related to Gauto et al., "Functional control of a 0.5 MDa TET aminopeptidase by a flexible loop revealed by MAS NMR".
In contains:
* 13C relaxation data (figure 2)
* 1H-13C dipolar-coupling data and all scripts to perform the fits and simulations
* Direct-Coupling-Analysis data
* 15N R1rho relaxation data (figure S3), corresponding to panels S3a and S3c.
DOI: 10.17632/gmcc4w4shz.1
title: Theba pisana pathogenicity assay

description: The raw data for the Theba pisana pathogenicity assay testing adult T. pisana against 3 species of Phasmarhabditis. Also includes the raw data for a dosage assay against T. pisana using P. califor
DOI: 10.17632/pyr8t5ng6r.1
title: Mitochondrial complex IV defects induce metabolic and signaling perturbations that expose potential vulnerabilities in HCT116 cells

description: Mutations in genes encoding cytochrome c oxidase (COX; mitochondrial complex IV) subunits and assembly factors (e.g., SCO1, SCO2, COA6) are linked to severe metabolic syndromes. Notwithstanding that SCO2 is under transcriptional control of tumour suppressor p53, the role of mitochondrial complex IV dysfunction in cancer metabolism remains obscure. Herein, we demonstrate that the loss of SCO2 in HCT116 colorectal cancer cells leads to significant metabolic and signaling perturbations. Specifically, abrogation of SCO2 increased NAD+ regenerating reactions and decreased glucose oxidation through citric acid cycle while enhancing pyruvate carboxylation. This was accompanied by a reduction in amino acid levels and the accumulation of lipid droplets. In addition, SCO2 loss resulted in hyperactivation of IGF1R/AKT axis with paradoxical downregulation of mTOR signaling which was accompanied by increased AMPK activity. Accordingly, abrogation of SCO2 expression appears to increase the sensitivity of cells to IGF1R and AKT, but not mTOR inhibitors. Finally, the loss of SCO2 was associated with reduced proliferation and enhanced migration of HCT116 cells. Collectively, herein we describe potential adaptive signaling and metabolic perturbations triggered by mitochondrial complex IV dysfunction.
DOI: 10.17632/hn3ssxw3pp.1
title: Intralesional measles, mumps, rubella vaccine versus tuberculin purified protein derivative injections in the treatment of palmoplantar and periungual warts: A double-blind randomized controlled trial

description: Supplementary materials of the study entitled "Intralesional measles, mumps, rubella vaccine versus tuberculin purified protein derivative injections in the treatment of palmoplantar and periungual warts: A double-blind randomized controlled trial"
DOI: 10.17632/xyz8zzvd66.1
title: Evaluaciones Externas en América Latina Procesos Logísticos. El Caso de Chile

description: La  evaluación  externa  en  América  Latina  ha tenido  avances  relativamente  semejantes, propósitos,  metodologías,  usos  y  formas  de divulgación  de  resultados  siguen  una  ruta similar. Los impactos son relativos, en algunos países  no  necesariamente  los  esperados,  el efecto a nivel pedagógico sigue  aún pendiente y  el  anhelado  propósito  de  hacer  de  la evaluación  una  herramienta  para  monitorear   procesos educativos,   menoscaba la paciente espera  de  quién  tiene  la  esperanza  de  una sociedad distinta por la vía de la educación.  
Si de formas de evaluar se trata en   algunos casos la creatividad  y dinamismo de la escuela  parecen silenciarse, pues un único modelo  de evaluación  externa  gana  terreno  y  las iniciativas   de otro tipo de evaluación quedan aplazadas,  so  pretexto  de  los  costos, cobertura,  estándares  y  software  de procesamiento de resultados. 
En  este  documento  el  lector  encontrará detalles  sobre  los  procesos  logísticos utilizados  para  la  aplicación  de  pruebas censales  y  muestrales  en  algunos  países  de América Latina, a partir de los mismos podrá hacer  inferencias    sobre  la  correspondencia entre medios y fines, todo ello en el marco de la política educativa de cada país.
DOI: 10.17632/vk344gdnwp.1
title: Data and data analysis programs for "Enhanced Spatial Resolution in Magnetic Resonance Imaging by Dynamic Nuclear Polarization at 5 K"

description: These are data and data analysis programs used in the manuscript "Enhanced Spatial Resolution in Magnetic Resonance Imaging by Dynamic Nuclear Polarization at 5 K", by Hsueh-Ying Chen, C. Blake Wilson, and Robert Tycko.

final_x_1p7um and final_x_2p6um are experimental MRI images with 1.7 micron and 2.6 micron isotropic resolution.  They can be viewed in ImageJ, using Import/Raw with image type=32-bit signed, width=128, height=128, number of images=256.

kdata1.txt and kdata4.txt are the k-space data used to generate the 1.7 micron and 2.6 micron resolution images, respectively.

transform_kdata1.f95 and transform_kdata4.f95 are Fortran programs to generate images from kdata1.txt and kdata4.txt.

simulate_image3.f95 is a Fortran program to fit simulated images with Gaussian point spread functions to the experimental MRI images.

sphere_simulation3.f95 is a Fortran program to generate simulated images from simulated k-space data, sampled to a specified value of kmax.

power_spectrum1.f95 and power_spectrum2_f95 are Fortran programs to calculate k-space power spectra in planes perpendicular to x and z, respectively, starting with either experimental or simulated images.
DOI: 10.48324/dandi.000218/0.220131.1608
title: Routing of Hippocampal Ripples to Subcortical Structures via the Lateral Septum

description: The mnemonic functions of hippocampal sharp wave ripples (SPW-Rs) have been studied extensively. Because hippocampal outputs affect not only cortical but also subcortical targets, we examined the impact of SPW-Rs on the firing patterns of lateral septal (LS) neurons in behaving rats. A large fraction of SPW-Rs were temporally locked to high-frequency oscillations (HFOs) (120–180 Hz) in LS, with strongest coupling during non-rapid eye movement (NREM) sleep, followed by waking immobility. However, coherence and spike-local field potential (LFP) coupling between the two structures were low, suggesting that HFOs are generated locally within the LS GABAergic population. This hypothesis was supported by optogenetic induction of HFOs in LS. Spiking of LS neurons was largely independent of the sequential order of spiking in SPW-Rs but instead correlated with the magnitude of excitatory synchrony of the hippocampal output. Thus, LS is strongly activated by SPW-Rs and may convey hippocampal population events to its hypothalamic and brainstem targets.
DOI: 10.17632/8trv8gwwc3.1
title: Characterizing dermatologic findings among patients with PTEN hamartoma tumor syndrome: results of a multi-center cohort study

description: Online Data Supplement
DOI: 10.17632/gx63tjcgxz.1
title: MOHAMMAD HAZAIMEH

description: The phytochemical screening of both products was run following the standard methods. Polar extracts of both B. aegyptiaca fruits and A. sativum bulbs were prepared to test their inhibition activities on E. coli stain through agar well diffusion method for 72 hours. The outcomes revealed that Balanites fruit contained saponins, tannins, glycosides, flavonoids, and terpenoids; whereas garlic bulbs contained glycosides, sterols, flavonoids, resins, and terpinoids.
DOI: 10.6084/m9.figshare.19096931
title: Test

description: This is a test.
DOI: 10.6084/m9.figshare.19096931.v2
title: Test

description: This is a test.
DOI: 10.6084/m9.figshare.19096931.v1
title: test.txt

description: This is a test.
DOI: 10.17632/j45wkj23c5.2
title: Do Brief Motivational Interventions Reduce Alcohol-impaired Driving Among College Students? A Meta-analysis of Individual Participant Data

description: This data source provides the data and R computing code to replicate the analysis reported in Mun et al. (2022). Do brief alcohol interventions reduce driving after drinking among college students? A two-step meta-analysis of individual participant data. Alcohol and Alcoholism, 57, 125–135. https://doi.org/10.1093/alcalc/agaa146

Abstract
Aims: College students who drink are at an increased risk of driving after drinking and alcohol involved traffic accidents and deaths. Furthermore, the persistence of driving after drinking over time underscores a need for effective interventions to prevent future drunk driving in adulthood. The present study examined whether brief alcohol interventions (BAIs) for college students reduce driving after drinking.
Methods: A two-step meta-analysis of individual participant data (IPD) was conducted using a combined sample of 6801 college students from 15 randomized controlled trials (38% male, 72% White and 58% first-year students). BAIs included individually delivered Motivational Interviewing with Personalized Feedback (MI + PF), Group Motivational Interviewing (GMI), and stand-alone Personalized Feedback (PF) interventions. Two outcome variables, driving after two+/three+ drinks and driving after four+/five+ drinks, were checked, harmonized and analyzed separately for each study and then combined for meta-analysis and meta-regression analysis.
Results: BAIs lowered the risk of driving after four+/five+ drinks (19% difference in the odds of driving after drinking favoring BAIs vs. control), but not the risk of driving after two+/three+ drinks (9% difference). Subsequent subgroup analysis indicated that MI + PF intervention was comparatively better than stand-alone PF or GMI. 
Conclusions: BAIs provide a harm reduction approach to college drinking. Hence, it is encouraging that BAIs reduce the risk of driving after heavy drinking among college students. However, there may be opportunities to enhance the intervention content and timing to be more relevant for driving after drinking and improve the outcome assessment and reporting to demonstrate its effect.