cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.8246315.v1
title: Increasing secondary-level teachers’ knowledge in statistics and probability: Results from a randomized controlled trial of a professional development program

description: Reflecting growing emphasis on data analysis and statistical thinking in the information age, mathematics curriculum standards in the U.S. have recently increased expectations for student learning in the domain of statistics and probability. More than 180 teachers in 36 public school districts in Florida applied for a two-week summer institute designed to increase teachers’ content and pedagogical content knowledge in statistics and probability. Individual teachers were assigned at random to a treatment or business-as-usual comparison group. The two-week institute increased teachers’ knowledge of statistics. Data analyses identified an interaction between years of teaching experience and treatment, indicating that the teachers with more than 10 years of experience had larger knowledge gains than their less-experienced peers. These results underscore the need for professional development for teachers so that they may implement policies emphasizing this branch of the mathematical sciences in the secondary mathematics curriculum. Given the observed lower baseline knowledge scores for teachers with more years of teaching experience, we posit these implications are particularly applicable to teachers who completed their own formal education more than 10 years ago.
DOI: 10.6084/m9.figshare.8246297
title: Table S1 from An optogenetic analogue of second-order reinforcement in <i>Drosophila</i>

description: Documents data and statistical report
DOI: 10.6084/m9.figshare.8246297.v1
title: Table S1 from An optogenetic analogue of second-order reinforcement in <i>Drosophila</i>

description: Documents data and statistical report
DOI: 10.6084/m9.figshare.8246273
title: Microtiming 4 JoPart2S2

description: eye-tracking data
DOI: 10.6084/m9.figshare.8246273.v1
title: Microtiming 4 JoPart2S2

description: eye-tracking data
DOI: 10.6084/m9.figshare.8246213
title: Microtiming 3 JoPart2S1

description: eye-tracking data
DOI: 10.6084/m9.figshare.8246201
title: Microtiming 2 JoPart1S2

description: eye-tracking data
DOI: 10.6084/m9.figshare.8246213.v1
title: Microtiming 3 JoPart2S1

description: eye-tracking data
DOI: 10.6084/m9.figshare.8246201.v1
title: Microtiming 2 JoPart1S2

description: eye-tracking data
DOI: 10.6084/m9.figshare.8246189
title: Microtiming 1 JoPart1S1

description: IDF files (SMI) with eye-tracking during microtiming grooves
DOI: 10.6084/m9.figshare.8246189.v1
title: Microtiming 1 JoPart1S1

description: IDF files (SMI) with eye-tracking during microtiming grooves
DOI: 10.6084/m9.figshare.8246180
title: Supervised_features_pool5_selected_cells_for_viz.txt

description: features
DOI: 10.6084/m9.figshare.8246180.v1
title: Supervised_features_pool5_selected_cells_for_viz.txt

description: features
DOI: 10.6084/m9.figshare.8246129
title: Subset of 2-to-9 atomic-molecules

description: Molecular structures optimized at MP2(full)/Def2-TZVPP level.<br><br>Please, cite the original publication ("The dataset of covalent bond lengths resulting from the first-principle calculations", by T.Yu. Nikolaienko, V. S. Chuiko, L.A. Bulavin; Computational and Theoretical Chemistry, 2019, DOI: 10.1016/j.comptc.2019.112508 ) if any data from this dataset is used.<br>
DOI: 10.6084/m9.figshare.8246129.v1
title: Subset of 2-to-9 atomic-molecules

description: Molecular structures optimized at MP2(full)/Def2-TZVPP level.<br><br>Please, cite the original publication ("The dataset of covalent bond lengths resulting from the first-principle calculations", by T.Yu. Nikolaienko, V. S. Chuiko, L.A. Bulavin; Computational and Theoretical Chemistry, 2019, DOI: 10.1016/j.comptc.2019.112508 ) if any data from this dataset is used.<br>
DOI: 10.6084/m9.figshare.8246123
title: Elachisocleis Raw data

description: Data used for describe diel and seasonal activity<br>
DOI: 10.6084/m9.figshare.8246126
title: A multiparametric study of gold nanoparticles cytotoxicity, internalization and permeability using an <i>in vitro</i> model of blood–brain barrier. Influence of size, shape and capping agent

description: Gold nanoparticles (AuNPs) have biomedical application on imaging and due to increased optical performance, star-shaped AuNPs are of special interest. Because shape, size and capping greatly influence their toxicokinetics and toxicodynamics, a systematic multiparametric comparative study of the influence of these parameters on the cytotoxicity, internalization, and in vitro permeability was conducted in human Cerebral Microvascular Endothelial Cell line (hCMEC/D3), an <i>in vitro</i> model of the human blood-brain barrier (BBB). AuNPs of different size (14 nm and ∼50 nm), shape (spheres and stars), and coating (11-mercaptoundecanoic acid or MUA and sodium citrate) were synthesized and fully characterized. The time- and concentration-dependent cytotoxic profile of the tested AuNPs differed for the different AuNPs. Generally, toxicity was greater for stars relative to sphere-shaped AuNPs, and citrate coating was more toxic than MUA. Regarding the influence of size, smaller-sized AuNPs were more cytotoxic when compared at the same Au concentration. However, when the concentration of AuNPs was expressed as the number of AuNPs/mL, a higher degree of cytotoxicity was noted for the larger ̴50 nm AuNPs. To understand the influence of size, shape and capping, a systematic study design, in which only one of the variables changes, is determinant for correct data interpretation. Considering the results herein presented, for the sake of comparison of differently-sized AuNPs, it is preferable to design the study based upon the number of nanoparticles, since at a fixed Au concentration the number of particles available to promote effect is higher for smaller-sized AuNPs. Cellular internalization also differed among the tested AuNPs; although all were unable to cross the in vitro BBB, the intracellularly accumulated AuNPs can induce cell damage and later compromise BBB integrity and permeability.
DOI: 10.6084/m9.figshare.8246117
title: Polymerizable dye for colored particles synthesis with potential use in immunoassays

description: Latex-particles are suitable for diagnosis purpose since they are able to interact with biological molecules. In this work, a colored monomer was synthesized between basic fuchsine(BF) and glycidyl methacrylate(GMA). BF-GMA obtaining was verified through UV-Vis, IR, NMR and Mass spectrometry. The synthesis of colored particles by emulsion polymerization of styrene and the BF-GMA monomer was studied by measuring conversion, particle diameter, BF incorporation, surface charge densities and also in a protein binding assay. Results confirmed the production of stable particles, with controlled size and high BF incorporation, capable of interacting with proteins efficiently, and being used in an immunoagglutination test.
DOI: 10.6084/m9.figshare.8246123.v1
title: Elachisocleis Raw data

description: Data used for describe diel and seasonal activity<br>
DOI: 10.6084/m9.figshare.8246126.v1
title: A multiparametric study of gold nanoparticles cytotoxicity, internalization and permeability using an <i>in vitro</i> model of blood–brain barrier. Influence of size, shape and capping agent

description: Gold nanoparticles (AuNPs) have biomedical application on imaging and due to increased optical performance, star-shaped AuNPs are of special interest. Because shape, size and capping greatly influence their toxicokinetics and toxicodynamics, a systematic multiparametric comparative study of the influence of these parameters on the cytotoxicity, internalization, and in vitro permeability was conducted in human Cerebral Microvascular Endothelial Cell line (hCMEC/D3), an <i>in vitro</i> model of the human blood-brain barrier (BBB). AuNPs of different size (14 nm and ∼50 nm), shape (spheres and stars), and coating (11-mercaptoundecanoic acid or MUA and sodium citrate) were synthesized and fully characterized. The time- and concentration-dependent cytotoxic profile of the tested AuNPs differed for the different AuNPs. Generally, toxicity was greater for stars relative to sphere-shaped AuNPs, and citrate coating was more toxic than MUA. Regarding the influence of size, smaller-sized AuNPs were more cytotoxic when compared at the same Au concentration. However, when the concentration of AuNPs was expressed as the number of AuNPs/mL, a higher degree of cytotoxicity was noted for the larger ̴50 nm AuNPs. To understand the influence of size, shape and capping, a systematic study design, in which only one of the variables changes, is determinant for correct data interpretation. Considering the results herein presented, for the sake of comparison of differently-sized AuNPs, it is preferable to design the study based upon the number of nanoparticles, since at a fixed Au concentration the number of particles available to promote effect is higher for smaller-sized AuNPs. Cellular internalization also differed among the tested AuNPs; although all were unable to cross the in vitro BBB, the intracellularly accumulated AuNPs can induce cell damage and later compromise BBB integrity and permeability.
DOI: 10.6084/m9.figshare.8246117.v1
title: Polymerizable dye for colored particles synthesis with potential use in immunoassays

description: Latex-particles are suitable for diagnosis purpose since they are able to interact with biological molecules. In this work, a colored monomer was synthesized between basic fuchsine(BF) and glycidyl methacrylate(GMA). BF-GMA obtaining was verified through UV-Vis, IR, NMR and Mass spectrometry. The synthesis of colored particles by emulsion polymerization of styrene and the BF-GMA monomer was studied by measuring conversion, particle diameter, BF incorporation, surface charge densities and also in a protein binding assay. Results confirmed the production of stable particles, with controlled size and high BF incorporation, capable of interacting with proteins efficiently, and being used in an immunoagglutination test.
DOI: 10.6084/m9.figshare.8246066
title: raw data of all treatmemts .zip

description: raw data for all treatments
DOI: 10.6084/m9.figshare.8246066.v1
title: raw data of all treatmemts .zip

description: raw data for all treatments
DOI: 10.6084/m9.figshare.8246030
title: Weakly_supervised_features_res4a_relu_selected_cells_for_viz.txt

description: extracted features by res4aReLU<br>
DOI: 10.6084/m9.figshare.8246030.v1
title: features_res4a_relu_selected_cells_for_viz.txt

description: extracted features by res4aReLU<br>
DOI: 10.6084/m9.figshare.8246024
title: Weakly_supervised_metadata_label_selected_cells_for_viz.tsv

description: label
DOI: 10.6084/m9.figshare.8246024.v2
title: metadata_label_selected_cells_for_viz.tsv

description: label
DOI: 10.6084/m9.figshare.8246024.v1
title: metadata_label_selected_cells_for_viz.tsv

description: label
DOI: 10.6084/m9.figshare.8245946
title: Neoadjuvant chemotherapy for muscle invasive bladder cancer: a nationwide investigation on survival

description: <b>Objectives:</b> Randomised controlled trials (RCTs) have investigated the use of neoadjuvant chemotherapy (NAC) and its effect on survival patients with non-metastatic muscle-invasive bladder cancer (MIBC). However, these RCTs have limited external validity and generalisability and, therefore, the current study aims to use real world evidence in the form of observational data to identify the effect that NAC may have on survival, compared to the use of radical cystectomy (RC) alone. <b>Materials and methods:</b> The study cohort (consisting of 944 patients) was selected as a target trial from the Bladder Cancer Data Base Sweden (BladderBaSe). This study calculated 5-year survival and risk of bladder cancer (BC)-specific and overall death by Cox proportional hazard models for the study cohort and a propensity score (PS) matched cohort. <b>Results:</b> Those who had received NAC had higher 5-year survival proportions and decreased risk of both overall and BC specific death (HR = 0.71, 95% CI = 0.52–0.97 and HR = 0.67, 95% CI = 0.48–0.94), respectively, as compared to patients who did not receive NAC. The PS matched cohort showed similar estimates, but with larger statistical uncertainty (Overall death: HR = 0.76, 95% CI = 0.53–1.09 and BC-specific death: HR = 0.73, 95% CI = 0.50–1.07). <b>Conclusion:</b> Results from the current observational study found similar point estimates for 5-year survival and of relative risks as previous studies. However, the results based on real world evidence had larger statistical variability, resulting in a non-statistically significant effect of NAC on survival. Future studies with detailed validated data can be used to further investigate the effect of NAC in narrower patient groups.
DOI: 10.6084/m9.figshare.8245946.v1
title: Neoadjuvant chemotherapy for muscle invasive bladder cancer: a nationwide investigation on survival

description: <b>Objectives:</b> Randomised controlled trials (RCTs) have investigated the use of neoadjuvant chemotherapy (NAC) and its effect on survival patients with non-metastatic muscle-invasive bladder cancer (MIBC). However, these RCTs have limited external validity and generalisability and, therefore, the current study aims to use real world evidence in the form of observational data to identify the effect that NAC may have on survival, compared to the use of radical cystectomy (RC) alone. <b>Materials and methods:</b> The study cohort (consisting of 944 patients) was selected as a target trial from the Bladder Cancer Data Base Sweden (BladderBaSe). This study calculated 5-year survival and risk of bladder cancer (BC)-specific and overall death by Cox proportional hazard models for the study cohort and a propensity score (PS) matched cohort. <b>Results:</b> Those who had received NAC had higher 5-year survival proportions and decreased risk of both overall and BC specific death (HR = 0.71, 95% CI = 0.52–0.97 and HR = 0.67, 95% CI = 0.48–0.94), respectively, as compared to patients who did not receive NAC. The PS matched cohort showed similar estimates, but with larger statistical uncertainty (Overall death: HR = 0.76, 95% CI = 0.53–1.09 and BC-specific death: HR = 0.73, 95% CI = 0.50–1.07). <b>Conclusion:</b> Results from the current observational study found similar point estimates for 5-year survival and of relative risks as previous studies. However, the results based on real world evidence had larger statistical variability, resulting in a non-statistically significant effect of NAC on survival. Future studies with detailed validated data can be used to further investigate the effect of NAC in narrower patient groups.
DOI: 10.6084/m9.figshare.8245646
title: Additional file 1: of Spatial epidemiological determinants of severe fever with thrombocytopenia syndrome in Miyazaki, Japan: a GWLR modeling study

description: Datasets of mesh areas with observed cases of severe fever with thrombocytopenia syndrome (SFTS), with altitude and farmland, in Miyazaki, Japan (XLSX 13 kb)
DOI: 10.6084/m9.figshare.8245646.v1
title: Additional file 1: of Spatial epidemiological determinants of severe fever with thrombocytopenia syndrome in Miyazaki, Japan: a GWLR modeling study

description: Datasets of mesh areas with observed cases of severe fever with thrombocytopenia syndrome (SFTS), with altitude and farmland, in Miyazaki, Japan (XLSX 13 kb)
DOI: 10.6084/m9.figshare.8245475
title: Additional file 2: of Comparison of the long-term follow-up and perioperative outcomes of partial nephrectomy and radical nephrectomy for 4 cm to 7 cm renal cell carcinoma: a systematic review and meta-analysis

description: Figure S2. (a)-2(d) Sensitive analysis of the (a) 5-year css (b)5-year os (c)10-year os(d) Declined eGFR. (ZIP 95 kb)
DOI: 10.6084/m9.figshare.8245475.v1
title: Additional file 2: of Comparison of the long-term follow-up and perioperative outcomes of partial nephrectomy and radical nephrectomy for 4 cm to 7 cm renal cell carcinoma: a systematic review and meta-analysis

description: Figure S2. (a)-2(d) Sensitive analysis of the (a) 5-year css (b)5-year os (c)10-year os(d) Declined eGFR. (ZIP 95 kb)
DOI: 10.6084/m9.figshare.8245469
title: Additional file 1: of Comparison of the long-term follow-up and perioperative outcomes of partial nephrectomy and radical nephrectomy for 4 cm to 7 cm renal cell carcinoma: a systematic review and meta-analysis

description: Figure S1. (a)-1(d). Funnel plots of the study. (a) 5-year css (b)5-year os (c)10-year os(d) Declined eGFR. (ZIP 82 kb)
DOI: 10.6084/m9.figshare.8245469.v1
title: Additional file 1: of Comparison of the long-term follow-up and perioperative outcomes of partial nephrectomy and radical nephrectomy for 4 cm to 7 cm renal cell carcinoma: a systematic review and meta-analysis

description: Figure S1. (a)-1(d). Funnel plots of the study. (a) 5-year css (b)5-year os (c)10-year os(d) Declined eGFR. (ZIP 82 kb)
DOI: 10.6084/m9.figshare.8245430
title: Additional file 1: of NanoARG: a web service for detecting and contextualizing antimicrobial resistance genes from nanopore-derived metagenomes

description: Table S1. Pseudomonas aeruginosa-like identified nanopore reads. (XLSX 4 kb)
DOI: 10.6084/m9.figshare.8245439
title: Additional file 2: of NanoARG: a web service for detecting and contextualizing antimicrobial resistance genes from nanopore-derived metagenomes

description: Table S2. Acinetobacter baumannii-like identified nanopore reads. (XLSX 4 kb)
DOI: 10.6084/m9.figshare.8245430.v1
title: Additional file 1: of NanoARG: a web service for detecting and contextualizing antimicrobial resistance genes from nanopore-derived metagenomes

description: Table S1. Pseudomonas aeruginosa-like identified nanopore reads. (XLSX 4 kb)
DOI: 10.6084/m9.figshare.8245439.v1
title: Additional file 2: of NanoARG: a web service for detecting and contextualizing antimicrobial resistance genes from nanopore-derived metagenomes

description: Table S2. Acinetobacter baumannii-like identified nanopore reads. (XLSX 4 kb)
DOI: 10.6084/m9.figshare.8245421
title: Additional file 6: of Codon usage optimization in pluripotent embryonic stem cells

description: Table S5. tRNA sequencing to quantify inosine levels in differentiated (diff) and self-renewing (self) human embryonic stem cells. (XLSX 26 kb)
DOI: 10.6084/m9.figshare.8245418
title: Additional file 5: of Codon usage optimization in pluripotent embryonic stem cells

description: Table S4. tRNA sequencing in self-renewing and differentiated (5â days) human embryonic stem cells. (XLSX 10 kb)
DOI: 10.6084/m9.figshare.8245415
title: Additional file 3: of Investigation of cell culture conditions for optimal foot-and-mouth disease virus production

description: Table S3. Cell-specific uptake and release rates of extracellular metabolites of infected BHK-2P cells and corresponding negative control with increasing extracellular glucose concentrations. Table S4. Cell-specific uptake and release rates of extracellular metabolites of infected BHK-2P cells and corresponding negative control with increasing extracellular glutamine concentrations. Table S5. Cell-specific uptake and release rates of extracellular metabolites of infected BHK-2P cells and corresponding negative control with increasing extracellular ammonium concentrations. Table S6. Cell-specific uptake and release rates of extracellular metabolites of infected BHK-2P cells and corresponding negative control at different cell densities and media exchange strategies. (XLSX 18 kb)
DOI: 10.6084/m9.figshare.8245418.v1
title: Additional file 5: of Codon usage optimization in pluripotent embryonic stem cells

description: Table S4. tRNA sequencing in self-renewing and differentiated (5â days) human embryonic stem cells. (XLSX 10 kb)
DOI: 10.6084/m9.figshare.8245421.v1
title: Additional file 6: of Codon usage optimization in pluripotent embryonic stem cells

description: Table S5. tRNA sequencing to quantify inosine levels in differentiated (diff) and self-renewing (self) human embryonic stem cells. (XLSX 26 kb)
DOI: 10.6084/m9.figshare.8245406
title: Additional file 2: of Investigation of cell culture conditions for optimal foot-and-mouth disease virus production

description: Table S1. Mean viral titers and standard deviation of cell density experiments. Table S2. Overview about the original virus isolates used in this study, their origin and passage history. (XLS 44 kb)
DOI: 10.6084/m9.figshare.8245409
title: Additional file 4: of Codon usage optimization in pluripotent embryonic stem cells

description: Table S3. Distribution of hetADAT targets at ribosome covered codons in (a) differentiated versus self-renewing hESCs. The A-site is highlighted in yellow and (b) differentiated embryoid bodies (EB) versus self-renewing mESCS. The A-site is highlighted in yellow. (XLSX 13 kb)
DOI: 10.6084/m9.figshare.8245415.v1
title: Additional file 3: of Investigation of cell culture conditions for optimal foot-and-mouth disease virus production

description: Table S3. Cell-specific uptake and release rates of extracellular metabolites of infected BHK-2P cells and corresponding negative control with increasing extracellular glucose concentrations. Table S4. Cell-specific uptake and release rates of extracellular metabolites of infected BHK-2P cells and corresponding negative control with increasing extracellular glutamine concentrations. Table S5. Cell-specific uptake and release rates of extracellular metabolites of infected BHK-2P cells and corresponding negative control with increasing extracellular ammonium concentrations. Table S6. Cell-specific uptake and release rates of extracellular metabolites of infected BHK-2P cells and corresponding negative control at different cell densities and media exchange strategies. (XLSX 18 kb)
DOI: 10.6084/m9.figshare.8245406.v1
title: Additional file 2: of Investigation of cell culture conditions for optimal foot-and-mouth disease virus production

description: Table S1. Mean viral titers and standard deviation of cell density experiments. Table S2. Overview about the original virus isolates used in this study, their origin and passage history. (XLS 44 kb)
DOI: 10.6084/m9.figshare.8245409.v1
title: Additional file 4: of Codon usage optimization in pluripotent embryonic stem cells

description: Table S3. Distribution of hetADAT targets at ribosome covered codons in (a) differentiated versus self-renewing hESCs. The A-site is highlighted in yellow and (b) differentiated embryoid bodies (EB) versus self-renewing mESCS. The A-site is highlighted in yellow. (XLSX 13 kb)
DOI: 10.6084/m9.figshare.8245400
title: Additional file 3: of Codon usage optimization in pluripotent embryonic stem cells

description: Table S2. Gene enrichment analyses (EnrichR) identifies highly expressed genes in tissues derived from all three germ layers using ARCHS4 enrichment tool. (XLSX 11 kb)
DOI: 10.6084/m9.figshare.8245391
title: Additional file 2: of Codon usage optimization in pluripotent embryonic stem cells

description: Table S1. RNA-seq and Ribo-seq data in the four replicates of self-renewing (self) and differentiating (diff) human embryonic stem cells. (XLSX 4135 kb)
DOI: 10.6084/m9.figshare.8245400.v1
title: Additional file 3: of Codon usage optimization in pluripotent embryonic stem cells

description: Table S2. Gene enrichment analyses (EnrichR) identifies highly expressed genes in tissues derived from all three germ layers using ARCHS4 enrichment tool. (XLSX 11 kb)
DOI: 10.6084/m9.figshare.8245391.v1
title: Additional file 2: of Codon usage optimization in pluripotent embryonic stem cells

description: Table S1. RNA-seq and Ribo-seq data in the four replicates of self-renewing (self) and differentiating (diff) human embryonic stem cells. (XLSX 4135 kb)