cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.13507687.v2
title: A Factor-Based Estimation of Integrated Covariance Matrix With Noisy High-Frequency Data

description: This article studies a high-dimensional factor model with sparse idiosyncratic covariance matrix in continuous time, using asynchronous high-frequency financial data contaminated by microstructure noise. We focus on consistent estimations of the number of common factors, the integrated covariance matrix and its inverse, based on the flat-top realized kernels introduced by Varneskov. Simulation results illustrate the satisfactory performance of our estimators in finite samples. We apply our methodology to the high-frequency price data on a large number of stocks traded in Shanghai and Shenzhen stock exchanges, and demonstrate its value for capturing time-varying covariations and portfolio allocation.
DOI: 10.6084/m9.figshare.13507687.v1
title: A Factor-Based Estimation of Integrated Covariance Matrix with Noisy High-Frequency Data

description: This paper studies a high-dimensional factor model with sparse idiosyncratic covariance matrix in continuous time, using asynchronous high-frequency financial data contaminated by microstructure noise. We focus on consistent estimations of the number of common factors, the integrated covariance matrix and its inverse, based on the flat-top realized kernels introduced by Varneskov (2016). Simulation results illustrate the satisfactory performance of our estimators in finite samples. We apply our methodology to the high-frequency price data on a large number of stocks traded in Shanghai and Shenzhen stock exchanges, and demonstrate its value for capturing time-varying covariations and portfolio allocation.
DOI: 10.6084/m9.figshare.23993519
title: Comparing adverse events of tenecteplase and alteplase: a real-world analysis of the FDA adverse event reporting system (FAERS)

description: The aim of this study is to monitor, identify, and compare the adverse events (AEs) related to tenecteplase and alteplase, with the objective of exploring the potential safety of tenecteplase for acute ischemic stroke (AIS) and guiding its use to enhance patient safety. In order to evaluate the disproportionality of AEs associated with tenecteplase and alteplase in real-world data, four algorithms (ROR, PRR, BCPNN, EBGM) were utilized as measures to detect signals of AEs related to both drugs. Subsequently, Breslow-Day statistical analysis was applied to compare the RORs of the main system organ classes (SOCs) and key preferred terms (PTs) between tenecteplase and alteplase. A statistical analysis was performed utilizing data gleaned from the Food and Drug Administration Adverse Event Reporting System (FAERS) database, encompassing 19,514,140 case reports from 2004Q1 to 2023Q1. There were 1,004 cases where tenecteplase was reported as the primary suspected (PS) and 2,363 tenecteplase-related adverse drug reactions (ADRs) at the PTs level were identified, the two data of alteplase were 10,945 and 25,266, respectively. The occurrence of drug-induced ADRs was analyzed across 27 organ systems, The analysis revealed several expected ADRs, such as Haemorrhage, Hypersensitivity which were consistent with the two drug-labels. It is of note that the signal strengths of ‘death,’ ‘ventricular fibrillation,’ ‘cardiogenic shock’ and ‘pneumonia aspiration’ at the PT level were markedly higher for tenecteplase than for alteplase, whereas the signal strength of ‘angioedema’ at the PT level was significantly higher for alteplase in comparison to tenecteplase. Additionally, unexpected significant ADRs associated with ocular adverse reactions and pneumonia aspiration at the PT level were identified, indicating potential AEs not currently mentioned in the drug instructions. This study identified and compared signals of ADRs associated with tenecteplase and alteplase, although tenecteplase is as effective as alteplase and has advantages such as ease of use and affordability, it cannot replace alteplase in the treatment of AIS until its safety profile is fully recognized. Additionally, previously unreported ocular ADRs and pneumonia were identified, providing valuable insights into the relationship between ADRs and the use of these thrombolytic drugs. These findings underscore the importance of continuous monitoring and effective detection of AEs to ultimately enhance the safety of AIS patients undergoing thrombolytic therapy.
DOI: 10.6084/m9.figshare.23993519.v1
title: Comparing adverse events of tenecteplase and alteplase: a real-world analysis of the FDA adverse event reporting system (FAERS)

description: The aim of this study is to monitor, identify, and compare the adverse events (AEs) related to tenecteplase and alteplase, with the objective of exploring the potential safety of tenecteplase for acute ischemic stroke (AIS) and guiding its use to enhance patient safety. In order to evaluate the disproportionality of AEs associated with tenecteplase and alteplase in real-world data, four algorithms (ROR, PRR, BCPNN, EBGM) were utilized as measures to detect signals of AEs related to both drugs. Subsequently, Breslow-Day statistical analysis was applied to compare the RORs of the main system organ classes (SOCs) and key preferred terms (PTs) between tenecteplase and alteplase. A statistical analysis was performed utilizing data gleaned from the Food and Drug Administration Adverse Event Reporting System (FAERS) database, encompassing 19,514,140 case reports from 2004Q1 to 2023Q1. There were 1,004 cases where tenecteplase was reported as the primary suspected (PS) and 2,363 tenecteplase-related adverse drug reactions (ADRs) at the PTs level were identified, the two data of alteplase were 10,945 and 25,266, respectively. The occurrence of drug-induced ADRs was analyzed across 27 organ systems, The analysis revealed several expected ADRs, such as Haemorrhage, Hypersensitivity which were consistent with the two drug-labels. It is of note that the signal strengths of ‘death,’ ‘ventricular fibrillation,’ ‘cardiogenic shock’ and ‘pneumonia aspiration’ at the PT level were markedly higher for tenecteplase than for alteplase, whereas the signal strength of ‘angioedema’ at the PT level was significantly higher for alteplase in comparison to tenecteplase. Additionally, unexpected significant ADRs associated with ocular adverse reactions and pneumonia aspiration at the PT level were identified, indicating potential AEs not currently mentioned in the drug instructions. This study identified and compared signals of ADRs associated with tenecteplase and alteplase, although tenecteplase is as effective as alteplase and has advantages such as ease of use and affordability, it cannot replace alteplase in the treatment of AIS until its safety profile is fully recognized. Additionally, previously unreported ocular ADRs and pneumonia were identified, providing valuable insights into the relationship between ADRs and the use of these thrombolytic drugs. These findings underscore the importance of continuous monitoring and effective detection of AEs to ultimately enhance the safety of AIS patients undergoing thrombolytic therapy.
DOI: 10.14473/csda/icjgda/60rppn
title: kf_data_bez_diakritiky_w4_chps_cz_v1.0_ENG.tab

description: Data_Contact forms
DOI: 10.14473/csda/icjgda/0nb0ln
title: TI_CHPS104, 105, 204, 205, 304, 305.pdf

description: Technical information
DOI: 10.6084/m9.figshare.23993664
title: "Machine learning versus multivariate logistic regression for predicting severe COVID-19 in hospitalized children with Omicron variant infection" -Source Data

description: This fileset contains: <br>a) The datasets (.csv file)<br>b) R script for models (Rmd format)<br><br>For any questions or additional data requests please contact the corresponding author.
DOI: 10.6084/m9.figshare.24517995
title: The application of nanopore targeted sequencing for pathogen diagnosis in bronchoalveolar lavage fluid of patients with pneumonia: a prospective multicenter study

description: To evaluate the value of nanopore targeted sequencing in diagnosing pneumonia pathogens. This large-scale multicentre prospective study performed in 8 hospitals across China from April to October 2022. Hospitalised patients with a diagnosis of pneumonia at admission were included. Complete clinical data were collected, and bronchoalveolar lavage fluid were obtained from each patient. These samples underwent simultaneous testing using conventional microbial testing, metagenomic next-generation sequencing, and nanopore targeted sequencing. A total of 218 patients were included. Among the 168 cases of pulmonary infection, 246 strains of pathogens were confirmed. Nanopore targeted sequencing outperformed conventional microbial testing, identifying more pathogens with a sensitivity increase of 47.9% (77.2% vs. 29.3%). Metagenomic next-generation sequencing had a sensitivity of 82.9%. Total of 70.1% patients had consistent results in both metagenomic next-generation sequencing and nanopore targeted sequencing. Nanopore targeted sequencing exhibited significantly higher sensitivity in detecting Pneumocystis jiroveci, cytomegalovirus, Mycobacterium tuberculosis, Nontuberculous mycobacteria, Streptococcus pneumoniae, and Mycoplasma pneumoniae compared to conventional microbial testing. However, metagenomic next-generation sequencing demonstrated higher sensitivity than nanopore targeted sequencing for Aspergillus (88.5% vs. 53.8%). Regarding the detection of co-infections, nanopore targeted sequencing displayed significantly higher sensitivity than conventional microbial testing (76.7% vs. 28.7%) and was on par with metagenomic next-generation sequencing (76.7% vs. 82.9%). Nanopore targeted sequencing performs equally well as metagenomic next-generation sequencing in bronchoalveolar lavage fluid for pathogen diagnosis in pneumonia, both methods showing higher sensitivity than conventional microbial testing. Nanopore targeted sequencing can be considered a reliable method for diagnosing pathogens in pneumonia.
DOI: 10.6084/m9.figshare.24517995.v1
title: The application of nanopore targeted sequencing for pathogen diagnosis in bronchoalveolar lavage fluid of patients with pneumonia: a prospective multicenter study

description: To evaluate the value of nanopore targeted sequencing in diagnosing pneumonia pathogens. This large-scale multicentre prospective study performed in 8 hospitals across China from April to October 2022. Hospitalised patients with a diagnosis of pneumonia at admission were included. Complete clinical data were collected, and bronchoalveolar lavage fluid were obtained from each patient. These samples underwent simultaneous testing using conventional microbial testing, metagenomic next-generation sequencing, and nanopore targeted sequencing. A total of 218 patients were included. Among the 168 cases of pulmonary infection, 246 strains of pathogens were confirmed. Nanopore targeted sequencing outperformed conventional microbial testing, identifying more pathogens with a sensitivity increase of 47.9% (77.2% vs. 29.3%). Metagenomic next-generation sequencing had a sensitivity of 82.9%. Total of 70.1% patients had consistent results in both metagenomic next-generation sequencing and nanopore targeted sequencing. Nanopore targeted sequencing exhibited significantly higher sensitivity in detecting Pneumocystis jiroveci, cytomegalovirus, Mycobacterium tuberculosis, Nontuberculous mycobacteria, Streptococcus pneumoniae, and Mycoplasma pneumoniae compared to conventional microbial testing. However, metagenomic next-generation sequencing demonstrated higher sensitivity than nanopore targeted sequencing for Aspergillus (88.5% vs. 53.8%). Regarding the detection of co-infections, nanopore targeted sequencing displayed significantly higher sensitivity than conventional microbial testing (76.7% vs. 28.7%) and was on par with metagenomic next-generation sequencing (76.7% vs. 82.9%). Nanopore targeted sequencing performs equally well as metagenomic next-generation sequencing in bronchoalveolar lavage fluid for pathogen diagnosis in pneumonia, both methods showing higher sensitivity than conventional microbial testing. Nanopore targeted sequencing can be considered a reliable method for diagnosing pathogens in pneumonia.
DOI: 10.6084/m9.figshare.7216526
title: MOESM2 of Proteomic and metabolomic analysis of the cellular biomarkers related to inhibitors tolerance in Zymomonas mobilis ZM4

description: Additional file 2: Sheet S1. A total of 1366 proteins identified in each inhibitor-treated group and the control.
DOI: 10.6084/m9.figshare.7216526.v1
title: MOESM2 of Proteomic and metabolomic analysis of the cellular biomarkers related to inhibitors tolerance in Zymomonas mobilis ZM4

description: Additional file 2: Sheet S1. A total of 1366 proteins identified in each inhibitor-treated group and the control.
DOI: 10.5281/zenodo.10687818
title: Large-volume felsic melt in deep continental subduction zones revealed from alkali granite in the Sulu orogen
DOI: 10.6084/m9.figshare.21995213
title: Files for Main Figure 5

description: <br>Files for generating main figure 5L1PA13_tcga_coad_strata: TCGA-COAD tumor strata using 4 L1PA13 locus expressioncor_test_L1PA13: Correlation test between genes and L1PA13 expressionL1PA13_PRJNA787646: L1PA13 expression of PRJNA787646 RNA-seqTCGA-COAD.cnv: Copy Number Variation matrix for TCGA-COAD cohort
DOI: 10.6084/m9.figshare.21995213.v13
title: Files for Main Figure 5

description: <br>Files for generating main figure 5L1PA13_strata: TCGA-COAD tumor strata using 4 L1PA13 locus expression. Also contain MSI, stage informationcor_test_L1PA13: Correlation test between genes and L1PA13 expression<br>
DOI: 10.5281/zenodo.10687817
title: Large-volume felsic melt in deep continental subduction zones revealed from alkali granite in the Sulu orogen
DOI: 10.6084/m9.figshare.21995213.v12
title: Files for Main Figure 5

description: <br>Files for generating main figure 5L1PA13_tcga_coad_strata: TCGA-COAD tumor strata using 4 L1PA13 locus expressioncor_test_L1PA13: Correlation test between genes and L1PA13 expressionL1PA13_PRJNA787646: L1PA13 expression of PRJNA787646 RNA-seqTCGA-COAD.cnv: Copy Number Variation matrix for TCGA-COAD cohort
DOI: 10.6084/m9.figshare.7216541
title: Additional file 3: of Development of a standardised set of metrics for monitoring site performance in multicentre randomised trials: a Delphi study

description: Examination of possible attrition bias in round 2 of the Delphi survey. (XLSX 18 kb)
DOI: 10.6084/m9.figshare.7216541.v1
title: Additional file 3: of Development of a standardised set of metrics for monitoring site performance in multicentre randomised trials: a Delphi study

description: Examination of possible attrition bias in round 2 of the Delphi survey. (XLSX 18 kb)
DOI: 10.5281/zenodo.10687832
title: Systematic Literature Review: Excel Analysis
DOI: 10.5281/zenodo.10687833
title: Systematic Literature Review: Excel Analysis
DOI: 10.6084/m9.figshare.25257472
title: Comparison of ANN, M5P and RF for prediction of lateritic soils’ permeability coefficient and shear strength

description: Predictive models were developed in this study using soft computing techniques including artificial neural network (ANN), M5P model tree (M5P) and random forest (RF) to predict laterite permeability coefficient and shear strength from index properties (specific gravity, linear shrinkage, liquid limit, plasticity index, fine sand content, and fines content). To achieve this goal, an experimental dataset obtained from laboratory analyses of three hundred laterite samples was divided into a model and a gaging dataset. The model dataset contains two hundred and forty data points, which were divided into training, testing and validation datasets, with 70% for training and 15% each for testing and validation of the proposed models. The gaging dataset contains sixty data points, which were used to evaluate and compare the proposed models’ performances with the existing models using the coefficient of determination, root mean squared error, mean absolute percentage error, and mean absolute error. The proposed models outperformed the existing models and provided satisfactory performance, with ANN models presenting the best performance, followed by RF and then M5P for both the permeability coefficient and the shear strength cases. This implies that the ANN models are the most reliable estimation for the prediction of lateritic soils’ permeability coefficient and shear strength. Thus, they can be used for practical purposes.
DOI: 10.6084/m9.figshare.17702358
title: A sensitive biomimetic enzyme-linked immunoassay method based on Au@Pt@Au composite nanozyme label and molecularly imprinted biomimetic antibody for histamine detection

description: In this paper, a sensitive biomimetic enzyme-linked immunoassay (BELISA) method based on an Au@Pt@Au composite nanozyme label was developed for histamine (HA) detection. A molecular imprinted polymer prepared directly on the 96-well plate served as a biomimetic antibody. A BELISA method was developed for HA standard solutions at concentrations ranging from 0.01 to 100.00 mg/L. Under optimal conditions, the novel BELISA method had a low limit of detection (0.069 mg/L) and high sensitivity (7.20 mg/L). The HA spiked in yellow rice wine and liqueur samples were detected by this BELISA method with the recoveries ranging from 84.28% to 108.82%. There was no significant difference of the results between the BELISA method and HPLC for the detection of HA in the red and white grape wine samples.
DOI: 10.6084/m9.figshare.17702358.v1
title: A sensitive biomimetic enzyme-linked immunoassay method based on Au@Pt@Au composite nanozyme label and molecularly imprinted biomimetic antibody for histamine detection

description: In this paper, a sensitive biomimetic enzyme-linked immunoassay (BELISA) method based on an Au@Pt@Au composite nanozyme label was developed for histamine (HA) detection. A molecular imprinted polymer prepared directly on the 96-well plate served as a biomimetic antibody. A BELISA method was developed for HA standard solutions at concentrations ranging from 0.01 to 100.00 mg/L. Under optimal conditions, the novel BELISA method had a low limit of detection (0.069 mg/L) and high sensitivity (7.20 mg/L). The HA spiked in yellow rice wine and liqueur samples were detected by this BELISA method with the recoveries ranging from 84.28% to 108.82%. There was no significant difference of the results between the BELISA method and HPLC for the detection of HA in the red and white grape wine samples.
DOI: 10.6084/m9.figshare.25244434
title: <b>Survey Response of Respondent from Freelancer in oil and gas industry </b>

description: Research exploring the relationship between work motivation, transformative leadership, absorptive capacity, and innovative behavior reveals important findings that highlight how work motivation and inspirational leadership can enhance the ability of organizations and individuals to absorb and utilize new knowledge, which in turn promotes innovative behavior
DOI: 10.6084/m9.figshare.7216685
title: Additional file 1: of Discovering the â Dark mattersâ in expression data of miRNA based on the miRNA-mRNA and miRNA-lncRNA networks

description: The 1078 significantly changed miRNA-mRNA interactions. (XLSX 29 kb)
DOI: 10.6084/m9.figshare.7216685.v1
title: Additional file 1: of Discovering the â Dark mattersâ in expression data of miRNA based on the miRNA-mRNA and miRNA-lncRNA networks

description: The 1078 significantly changed miRNA-mRNA interactions. (XLSX 29 kb)
DOI: 10.25592/uhhfdm.14074
title: EpInt fMRI study

description: All data that was recorded in the EpInt fMRI study by Anna-Maria Grob.
DOI: 10.25592/uhhfdm.14072
title: EEG_TMS_Study

description: This file contains all data from the EEG/TMS study conducted by Anna-Maria Grob.
DOI: 10.25592/uhhfdm.14068
title: Handschriftenbeschreibung Lübeck, Stadtbibliothek, Ms. hist. 8° 1a

description: Kurzbeschreibung der Handschrift Lübeck, Stadtbibliothek, Ms. hist. 8° 1a zur Ergänzung des Handschriftencensus. Nur die deutschsprachigen und latinischdeutschen Texten wurden einzeln erfasst.
description: The research for this project was funded by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) within the Sonderforschungsbereich 950 (SFB 950). The research was conducted within the scope of the Centre for the Study of Manuscript Cultures (CSMC) at Universität Hamburg.
DOI: 10.25592/uhhfdm.14067
title: Handschriftenbeschreibung Lübeck, Stadtbibliothek, Ms. hist. 8° 1a

description: Kurzbeschreibung der Handschrift Lübeck, Stadtbibliothek, Ms. hist. 8° 1a zur Ergänzung des Handschriftencensus. Nur die deutschsprachigen und latinischdeutschen Texten wurden einzeln erfasst.
description: The research for this project was funded by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) within the Sonderforschungsbereich 950 (SFB 950). The research was conducted within the scope of the Centre for the Study of Manuscript Cultures (CSMC) at Universität Hamburg.
DOI: 10.3886/e197782v3
title: ECIN Replication Package for "Fertility and Long-Term Economic Growth"

description: Empirical studies have generally found that higher fertility has a negative or insignificant effect on economic growth. This article argues that this is because existing studies have failed to capture the long-term lagged effects of fertility. By estimating a long-term lagged panel model using data from 137 countries from 1960 to 2016, I find that higher fertility first reduces and then increases economic growth, and the long-term average effect is significantly positive. This finding is robust when focusing on countries at different development levels, exploiting exogenous fertility shocks from global family planning campaigns, and capitalizing on within-country fertility variation resulting from China's one-child policy.
DOI: 10.3886/e197782v1
title: ECIN Replication Package for "Fertility and Long-Term Economic Growth"

description: Empirical studies have generally found that higher fertility has a negative or insignificant effect on economic growth. This article argues that this is because existing studies have failed to capture the long-term lagged effects of fertility. By estimating a long-term lagged panel model using data from 137 countries from 1960 to 2016, I find that higher fertility first reduces and then increases economic growth, and the long-term average effect is significantly positive. This finding is robust when focusing on countries at different development levels, exploiting exogenous fertility shocks from global family planning campaigns, and capitalizing on within-country fertility variation resulting from China's one-child policy.
DOI: 10.3886/e197782v1-145944
title: ECIN Replication Package for "Fertility and Long-Term Economic Growth"

description: Empirical studies have generally found that higher fertility has a negative or insignificant effect on economic growth. This article argues that this is because existing studies have failed to capture the long-term lagged effects of fertility. By estimating a long-term lagged panel model using data from 137 countries from 1960 to 2016, I find that higher fertility first reduces and then increases economic growth, and the long-term average effect is significantly positive. This finding is robust when focusing on countries at different development levels, exploiting exogenous fertility shocks from global family planning campaigns, and capitalizing on within-country fertility variation resulting from China's one-child policy.