cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.21304614.v1
title: Supplementary Material for: Stanniocalcin 2 is upregulated by calcium-sensing receptor and protects human vascular smooth muscle cells from high phosphate-induced apoptosis

description: Introduction Apoptosis of vascular smooth muscle cells induced by hyperphosphatemia is a critical mechanism of chronic kidney disease-related vascular disorders. The present study investigated whether extracellular calcium-sensing receptor (CaSR) regulates stanniocalcin 2 (STC2) expression in HAoSMCs in vitro and whether induced STC2 protects HAoSMCs from high phosphate-induced apoptosis. Methods and Results The constitutive expression of STC2 was confirmed in cultured HAoSMCs. STC2 mRNA and protein levels were increased significantly by calcimimetic NPS R-568 at a concentration of 1 microM with or without high phosphate. Conversely, calcilytic NPS-2143 at a concentration of 1 microM resulted in significantly decreased STC2 mRNA levels regardless of whether high phosphate was present, but decreased STC2 protein levels were only found under the high phosphate condition. Confocal microscopy demonstrated colocalization of STC2 and plasma membrane or endoplasmic reticulum markers. STC2 overexpression significantly reduced caspase-3 levels in HAoSMCs with or without high phosphate, whereas STC2 silencing resulted in significantly increased caspase-3 levels. TUNEL staining revealed the same tendency. Similar to STC2 overexpression, NPS R-568 treatment significantly reduced caspase-3 levels in HAoSMCs, but STC2 silencing abolished the protective effect of NPS R-568, which was also supported by TUNEL staining. Conclusion This is the first evidence that STC2 is regulated by CaSR in HAoSMCs. CaSR activation and the subsequent STC2 increase have putative anti-apoptotic effects against high phosphate. Thus, calcimimetics are promising agents to treat vascular injury associated with uremia.
DOI: 10.6084/m9.figshare.14565927.v1
title: Supplementary Material for: Comparisons of Efficacy and Safety between Triple (Inhaled Corticosteroid/Long-Acting Muscarinic Antagonist/Long-Acting Beta-Agonist) Therapies in Chronic Obstructive Pulmonary Disease: Systematic Review and Bayesian Network Meta-Analysis

description: <b><i>Background:</i></b> Various combinations of inhaled corticosteroid (ICS), long-acting muscarinic antagonist (LAMA), and long-acting beta-agonist (LABA) have been used as triple therapy for stable chronic obstructive pulmonary disease (COPD). <b><i>Objective:</i></b> Our study was conducted to answer whether there were significant differences among various combinations in efficacy, for reducing exacerbation or mortality, and in safety, for increasing cardiovascular events or pneumonia. <b><i>Method:</i></b> We searched parallel-group randomized controlled trials (RCTs) comparing ICS/LAMA/LABA with other inhaled drugs in patients with stable COPD for at least 12 weeks in PubMed, EMBASE, the Cochrane Library, and clinical trial registries from inception to December 31, 2019. We conducted a network meta-analysis with Bayesian statistics using a random-effects model with heterogeneous variance structure (PROSPERO, CRD42019126757). <b><i>Results:</i></b> Nine different combinations of ICS/LAMA/LABA were identified in 21 RCTs containing 29,892 patients with moderate to very severe COPD. We could not find any significant evidence suggesting a better treatment for reducing total exacerbations or all-cause mortality among ICS/LAMA/LABA combinations. There were also no significant differences in moderate to severe exacerbation, COPD-related mortality, or cardiovascular disease-related mortality among ICS/LAMA/LABA combinations, and the risk of major adverse cardiovascular events was not different. A significantly lower risk of pneumonia was found in fluticasone propionate (FP)/glycopyrrolate/salmeterol (SAL) than FP/tiotropium/SAL {median odds ratio [OR] (95% credible interval [CrI]) = 0 [0–0.72]} and FP/umeclidinium/SAL {median OR (95% Crl) = 0 [0–0.97]}. <b><i>Conclusion:</i></b> There were no significant differences in clinical outcomes, including acute exacerbation and all-cause mortality among various ICS/LAMA/LABA combinations in patients with moderate to very severe COPD.
DOI: 10.17632/n8x59pmjpt.1
title: CAM in DM: Findings from studies included in Scoping Review

description: Characteristics and Findings from studies included in Scoping Review
DOI: 10.6084/m9.figshare.28704494.v1
title: Supplemetary matherial 1

description: Latitude and Longitude for the Areas
DOI: 10.6084/m9.figshare.21952853.v2
title: . Study timeline.pdf

description: <strong>Aim</strong> This study aimed to evaluate the impact of self-preventive measures (handwashing, mask-wearing, and social distancing) on preventing the Coronavirus Disease-2019 (COVID-19) infection in Saudi Arabia (KSA). <strong>Methods</strong> An unmatched case-control study (1 to 1 ratio) was conducted with a sample size of 1102. The researchers used descriptive, bivariate, and multivariate analyses to determine the effect of handwashing, mask-wearing behavior, and social gatherings on COVID-19 infection. <strong>Results</strong> The results evinced that participants who believed that the facemask was important for preventing COVID-19 infection were more likely protected against the disease (OR=0.450; 0.320—0.631). Using a facemask during social visits and shopping indicated a lower protective effect than using it at work (OR=1.299; 1.011—1.668). The type of mask (disposable versus cloth; OR=0.929; 0.590—0.1.462) and its wearing period (1&lt; dayversus ≤1 day; OR=0.907; 0.662—1.243) showed an almost neutral statistical association with acquiring the infection. Contrarily, handwashing time for ≥20 seconds, compared to a shorter time, had a statistically significant protective association with the infection even after adjusting the odds ratio (OR=0.616; 0.4763—0.796). It was also noted that gathering with relatives and friends ≥4 times per month exhibited a higher and statistically significant association with the infection compared to the lower times (OR=1.347; 1.046—1.734). Furthermore, people who prayed five times a day at the mosque showed a higher risk of infection than those who prayed less than five times (adjusted OR=1.740; 1.152—2.626). <strong>Conclusions</strong> This study suggested that handwashing for more than 20 seconds is the most important preventive factor among all considerations investigated. Moreover, it was noticed that disposable and cloth facemasks may have the same effect regardless of the wearing period or sterilization status. Furthermore, gathering with relatives and friends, as well as praying five times a day at the mosque, were ascertained as significant social factors in acquiring the COVID-19 infection.
DOI: 10.6084/m9.figshare.26010616.v2
title: Building Info. and vulnerability fn.

description: This dataset provides, design information of the building and its vulnerability functions.
DOI: 10.6084/m9.figshare.21352971.v3
title: HLJ_edaphic_variables

description: Characteristics of soil samples in monocropping and intercropping systems with different fertilization treatments. CK, plots without fertilizer added; CF_I, plots with 60 kg N ha-1 of urea; CF_II, plots with 120 kg N ha-1 of urea; OF_I, plots with sheep manure (0.035% N, equals 60 kg N ha-1 year-1); OF_II, plots with sheep manure (0.035% N, equals 120 kg N ha-1 year-1)..Different lowcase letters denote significant differences between treatment at the 0.05 probability level on the basis of Kruskal-Wallis tests corrected for multiple testing. Soil nutrients include total Carbon (TC), total nitrogen (TN), dissolved organic nitrogen (DON), dissolved organic carbon (DOC), nitrate (NO3--N), ammonium (NH4+-N), soil available phosphorus (AP), soil available potassium (AK), soil total phosphorus (TP), soil total potassium (AK), microbial biomass carbon (MBC) and nitrogen (MBN). Characteristics of soil samples in monocropping and intercropping systems with different fertilization treatments. CK, plots without fertilizer added; CF_I, plots with 60 kg N ha-1 of urea; CF_II, plots with 120 kg N ha-1 of urea; OF_I, plots with sheep manure (0.035% N, equals 60 kg N ha-1 year-1); OF_II, plots with sheep manure (0.035% N, equals 120 kg N ha-1 year-1)..Different lowcase letters denote significant differences between treatment at the 0.05 probability level on the basis of Kruskal-Wallis tests corrected for multiple testing. Soil nutrients include total Carbon (TC), total nitrogen (TN), dissolved organic nitrogen (DON), dissolved organic carbon (DOC), nitrate (NO3--N), ammonium (NH4+-N), soil available phosphorus (AP), soil available potassium (AK), soil total phosphorus (TP), soil total potassium (AK), microbial biomass carbon (MBC) and nitrogen (MBN).
DOI: 10.6084/m9.figshare.7980176.v5
title: Supplementary files for transcriptome profiling of induced susceptibility effects on soybean- soybean aphid interaction

description: This dataset consists of two Excel spreadsheet files in <b>.xlsx</b> format, a Supplementary File and Table S1 in <b>.docx</b> format. The image files are in <b>.tiff </b>format. The data were generated as part of a study which used RNA sequencing to generate transcriptional datasets for transcriptome profiling of induced susceptibility effects on soybean- soybean aphid (Hemiptera: Aphididae) interaction.<br>The data consists of the following files:Supplementary file 1: Methodology description<br>Table S1: Statistics of the transcriptomic data using RNA-seq pipeline used in this study.<br>Figure S1: A flow chart representing experimental methods.<br>Figure S2: A flow chart showing the RNA-seq data analysis pipeline.<br>Figure S3: The hierarchical clustering of top 3,000 variable genes.<br>Figure S4: The correlation between the samples using the top 75% genes.<br>Figure S5: Quality metrics of G. max sequencing data. (a) Mean quality scores per position. (b) Per sequence quality scores. (c) GC content distribution. (d) Read length distribution<br>Data File 21: The transformed transcript abundance counts for all the samples.<br>Data File 22: The hierarchical clustering of top 3,000 variable genes.<br><br><br><br><br>
DOI: 10.6084/m9.figshare.20098304.v1
title: Additional file 4 of Microtremor array surveys and development of the velocity model in the Hakodate Plain, Hokkaido, Japan

description: Additional file 4. Observed phase velocity and its standard deviation at KMI in the CSV format.
DOI: 10.6084/m9.figshare.13153214.v1
title: Supplementary Material for: <b><i>CYP24A1</i></b> rs1570669 Variant Has a Protective Effect against Tumors of the Urinary System

description: <b><i>Background:</i></b> Common malignant tumors of the urinary system include renal cell carcinoma, bladder carcinoma, and prostate cancer. The research on the <i>CYP24A1</i> gene for prostate cancer is mainly concentrated in European and American populations, and there are few studies in the Chinese population. Therefore, we selected bladder cancer, prostate cancer, and renal cancer as the research objects to explore the influence of <i>CYP24A1</i> on the genetic susceptibility of urinary system tumors. <b><i>Materials and Methods:</i></b> rs6068816, rs2296241, rs2762934, and rs1570669 in 529 patients and 523 controls were genotyped via the Agena MassARRAY. Logistic regression analysis was used to evaluate the odd ratios (ORs) and 95% confidence intervals (CIs) of two SNPs with susceptibility of urinary system cancer. Database predicts the expression of the <i>CYP24A1</i> gene in urinary system cancer. <b><i>Results:</i></b> Individuals with the AG genotype of <i>CYP24A1</i> rs1570669 has a 28% lower risk of developing urinary system tumors (OR = 0.72, 95% CI: 0.56–1.13, <i>p</i> = 0.016) and has a 31% lower risk of developing renal cancer (OR = 0.69, 95% CI: 0.51–0.92, <i>p</i> = 0.012). <b><i>Conclusions:</i></b> <i>CYP24A1</i> rs1570669 may play an important role in the susceptibility of tumors of the urinary system and renal cancer.
DOI: 10.6084/m9.figshare.21431376.v1
title: O Brasil é realmente um país polarizado? Análise das eleições presidenciais de 1989 a 2018

description: ABSTRACT We analyze the eight Brazilian presidential elections of the post-military dictatorship period, given the central role they played in the organization of our Coalition Presidentialism. We investigate the electoral and geographic polarization in these elections, their characteristics and dynamics, analyzing with spatial statistics the voting in the 5,570 municipalities. We found significant polarization in all of them. However, they vary in direction and intensity. There are two periods delimited by the 2002 election. There are also two trajectories, observed in more detail through statistics and maps of the electoral territories. The PT and PSDB parties have different dynamics throughout the series, but from 2006 onwards they remain geographically polarized with the same degree of intensity and with an upward trend. The PRN (Collor) and PSL (Bolsonaro) parties, at the extremes of the series, are protagonists of two atypical elections, with polarization and territorial alignment similar to those of the PSDB.
DOI: 10.5281/zenodo.15313829
title: Hypothalamic-pituitary-adrenal dynamics in early-stage COVID-19: A case report

description: Sequence analysis of the SARS-CoV-2 RNA
DOI: 10.5281/zenodo.15313830
title: Hypothalamic-pituitary-adrenal dynamics in early-stage COVID-19: A case report

description: Sequence analysis of the SARS-CoV-2 RNA
DOI: 10.6084/m9.figshare.1149954.v1
title: A directed network of hyperlinks between weblogs on US politics, recorded in 2005 by Adamic and Glance.

description: Political blogosphere Feb. 2005<br>Data compiled by Lada Adamic and Natalie Glance Node "value" attributes indicate political leaning according to: 0 (left or liberal)<br>1 (right or conservative) Data on political leaning comes from blog directories as indicated. Some<br>blogs were labeled manually, based on incoming and outgoing links and posts<br>around the time of the 2004 presidential election. Directory-derived<br>labels are prone to error; manual labels even more so. Links between blogs were automatically extracted from a crawl of the front<br>page of the blog. These data should be cited as Lada A. Adamic and Natalie Glance, "The<br>political blogosphere and the 2004 US Election", in Proceedings of the<br>WWW-2005 Workshop on the Weblogging Ecosystem (2005).
DOI: 10.6084/m9.figshare.24579124.v1
title: Proteromonas lacertae genome Braker3 protein predictions

description: Genes predicted for the Proteromonas lacertae genome using Braker3
DOI: 10.6084/m9.figshare.28830218.v1
title: Raw data and MATLAB codes.zip

description: Molecular Communications (MC), transferring information via chemical signals, holds promise for transformative healthcare applications within the Internet of Bio-Nano Things (IoBNT) framework. Despite promising advances toward practical MC systems, progress has been constrained by experimental testbeds that are costly, difficult to customize, and require labor-intensive fabrication. Here, we address these challenges by introducing a low-cost (~1 per unit), rapidly fabricated (&lt;1 hour), and highly customizable microfluidic testbed that integrates a cross‑shaped, pressure‑modulated microchannel transmitter that generates programmable pulses and a receiver. This platform enables precise spatiotemporal control over chemical signals and supports reconfigurable channel architectures along with on-demand sensor functionalization. As a proof of concept, we demonstrate a pH-based MC system combining a polyaniline (PANI)-functionalized screen printed sensor for real-time pH signal detection with a programmable hydrodynamic gating architecture, patterned in a double-sided adhesive tape, as the transmitter. By dynamically mixing phosphate-buffered saline (PBS) with an acidic solution (pH 3), the testbed reliably generates pH-encoded pulses. Experimental results confirm robust control over pulse amplitude and pulse width, enabling the simulation of end-to-end MC scenarios with 4-ary concentration shift keying (CSK) modulation. By combining affordability and rapid prototyping without compromising customizability, this platform is poised to accelerate the translation of MC concepts into practical IoBNT applications.
DOI: 10.6084/m9.figshare.28025042.v1
title: Supplementary Material for: Meta-analysis of global distribution of root-caries prevalence in middle-aged and elderly

description: Introduction: Root caries (RC) remains a global health problem leading to negative impacts on an elderly person’s well-being causing oral health–related quality of life issues, as inadequate nutrition and detrimental oral functionality. The present systematic review with meta-analysis is designed to synthesize existing research findings on the prevalence and experience of root caries globally over the past 30 years. It aims to describe its distribution by country and explore its links with various socioeconomic indicators.
Methods: Selection criteria: Three electronic databases (PubMed, Embase and Scopus) were screened for observational epidemiological studies (cross-sectional and cohort studies) reporting the prevalence of RC and/or mean RC experience between 1990 and 2023. No language were applied. Study selection, data extraction and quality assessment were done in duplicate. . risk of bias was graded with customized quality assessment tools (Study Quality Assessment Tools NHLBI, NIH). Data collection and analysis: studies reporting on (1) root caries experience (mean and SD) and (2) on root caries prevalence (%), were used synthesize the results. It was assessed as decayed, missing, and filled teeth (RDMFT)
Results: A total of 91 publications were included in the descriptive analysis; the estimated overall pooled mean RC was 2.87 teeth and the global estimated random-effects pooled RC prevalence was 41%. Low gross national income (GNI) countries reported a low mean number of RC (1.35 GNI&lt;$5000), while high GNI countries reported a higher mean number of RC (3.45 GNI $10000- $19999). Countries of higher inequalities (Gini index) reported lower means medium RC (1.98 teeth) than countries with no inequalities (4.90 teeth). 
Conclusion: This study highlights the high caries burden among adult population globally by estimating overall trends and comparing against factors including area, GNI and Gini-index. The large magnitude of these inequities indicates that oral health equity can only be achieved taking into account socioeconomic factors on a global scale. 
The lack of uniform data collecting among studies as well as knowledge gap regarding the incidence and experience of RC in different countries.
DOI: 10.15468/dl.4sjum6
title: Occurrence Download

description: A dataset containing 40 species occurrences available in GBIF matching the query:
{
 "and" : [
 "HasGeospatialIssue is false",
 "HasCoordinate is true",
 "OccurrenceStatus is Present",
 {
 "not" : {
 "BasisOfRecord" : [
 "is one of (Observation, Human Observation, Machine Observation, Living Specimen)"
 ]
 }
 },
 "TaxonKey is Ophion ellenae Johansson, 2019"
 ]
}

 The dataset includes 40 records from 5 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0009460-250426092105405/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.6084/m9.figshare.12639221.v1
title: Supplementary Material for: ADHD Is Associated with a Higher Risk for Traumatic Events, Self-Reported PTSD, and a Higher Severity of PTSD Symptoms in Alcohol-Dependent Patients

description: <b><i>Introduction:</i></b> Alcohol dependence (AD) is frequently associated with attention-deficit/hyperactivity disorder (ADHD) as well as with posttraumatic stress disorder (PTSD). <b><i>Objective:</i></b> Aim of this study was to investigate whether in patients with AD, ADHD is associated with an increased rate of exposure to potentially traumatic events (PTEs) and PTSD, with increased PTSD severity and higher impact on daily functioning. <b><i>Methods:</i></b> Patients with AD were thoroughly assessed for ADHD during long-term residential treatment. Participants also completed the Posttraumatic Diagnostic Scale (PDS). The PDS is a 49-item self-report instrument that assesses exposure to different PTEs, DSM-IV criteria for PTSD, severity of PTSD, and related functional impairment. <b><i>Results:</i></b> Of 341 patients with AD, 66 were diagnosed with ADHD (19%). ADHD was associated with a more frequent exposure to PTEs (88 vs. 65%, <i>p</i> &lt; 0.001). In patients with PTEs (<i>n</i> = 237), odds for PTSD were higher in ADHD versus no-ADHD patients (OR 8.9, 95% CI 3.9–20.5). Furthermore, PTSD severity and functional impairment were increased in ADHD patients. <b><i>Conclusions:</i></b> ADHD in patients with AD is associated with a higher frequency of PTEs and PTSD with more severe and more impairing PTSD symptoms. In alcohol-dependent patients with ADHD, regular screening for PTSD should be considered.
DOI: 10.6084/m9.figshare.21679409.v3
title: Data and analysis code of "Regional and tele-connected impacts of the Tibetan Plateau surface darkening"

description: Attached please find the data and analysis code of "Regional and tele-connected impacts of the Tibetan Plateau surface darkening" (https://www.nature.com/articles/s41467-022-35672-w) Please cite the article if you want to use these data and analysis code ( Tang, S., Vlug, A., Piao, S. <em>et al.</em> Regional and tele-connected impacts of the Tibetan Plateau surface darkening. <em>Nat Commun</em> <strong>14</strong>, 32 (2023). https://doi.org/10.1038/s41467-022-35672-w ) <br> Above data and analysis codes include: 1) AnalysisData_Climate.m: Analysis code for climate experiments. Use Matlab to open and run this file. Note: some pathways in this code file are absolute pathways and should be changed, otherwise errors will be reported. 2) AnalysisData_Glacier.m: Analysis code for glacier simulations. Use Matlab to open and run this file. Results of the analysis part have been stored at Glacier_difference.mat. Note: some pathways in this code file are absolute pathways and should be changed, otherwise errors will be reported. 3) Basedata.mat: Store the base dataset used for the analysis in AnalysisData_Climate.m. 4) Climate_difference.mat: All the variables in this mat are derived from the climate experiments. GlobalX means the annual mean results, SummerX means the boreal summer results. The size of these variables: longitude*latitude*(atmospheric layer)*3 (CTL results, SCE results, significant). This data is used for AnalysisData_Climate.m. 5) Glacier_difference,mat: The meaning of each variables in this data is list in AnalysisData_Glacier.m. This data is used for AnalysisData_Glacier.m. 6) AnalysisData.zip: store the 99-year simulation results of some variables used in the AnalysisData_Climate.m. 7) Wilcoxon.m: Judge whether the difference is significant ( non-parametric Wilcoxon signed-rank test). 8) TPPolygon.shp: the shp file of the Tibetan Plateau. 9) brewermap.m: generate the colormap of each figure. 10) 00_rgi60_regions_xxx: shp file of the 13 (or 15) second-order regions over the Tibetan Plateau and its surrounding regions (Pfeffer et al., 2014; RGI Consortium et al., 2017). 11) draw_radar2.m: this file is used to draw figure 2(b). 12) p50_degree_glacier_volume_km3.tif: This tif is provided by Farinotti et al., 2019. 13) suppl_GlacierMIP_results.nc: this nc file is provided by Marzeion et al., 2020 <br> If you have any questions or suggestions, please contact shuchangtang@pku.edu.cn
DOI: 10.6084/m9.figshare.3512117.v1
title: Appendix A. A summary table of population density and private land areas occupied by urban, exurban, and crop land uses for each ecoregion and county type.

description: A summary table of population density and private land areas occupied by urban, exurban, and crop land uses for each ecoregion and county type.
DOI: 10.6084/m9.figshare.22215139.v1
title: Full anonymised answers of all questionnaires (1).xlsx

description: Full anonymised answers of all questions