cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.5286/isis.e.rb2010418-1
title: Tailoring micelle shape via solvent interactions in deep eutectic solvents

description: The manipulation of micelle morphology is key to exploiting surfactants in applications from formulation of creams and gels for drug delivery to templating of mesoporous materials. Novel deep eutectic solvents (DES) are now being investigated as solvents for materials synthesis and as drug delivery systems since their components frequently include species which can enhance skin penetration. We are therefore investigating methods for altering micelle morphologies in these green solvents, which are less toxic than typical ionic liquids, but share their tuneable physicochemical properties. Here we propose to study the effects of a DES component that can potentially have both electrostatic and hydrophobic interactions with cationic micelles, to determine whether micelle elongation can extend to formation of wormlike micelles in these solutions.
DOI: 10.5286/isis.e.rb2010727
title: SANS Study of interaction of Monoclonal Antibody with Non-ionic Surfactant

description: Although we have made an extensive study of surface and interfacial adsorption of an engineered monoclonal antibody COE3, its solution structure has never been studied. As we know how COE3 is modified from the native IgG1, the proposed work here will lead to a better understanding of its conformation together with its constituting Fab and Fc in solution under different pHs. Then, we will examine how Fab, Fc and the whole mAb interact with modified Tween 80 with 7 and 13 EOs (PS80(7EO), PS80(13EO)). Preliminary studies have indicated that COE3 would interact with PS80(7EO) more favourably than the ones with longer EOs. Through appropriate contrast variations, SANS will help unravel the structural details relating to the binding of the nonionic surfactants to COE3 or its fragments. We will explore the new SASview based MD simulations for data analysis via support from the NIST team.
DOI: 10.5286/isis.e.rb2010727-1
title: SANS Study of interaction of Monoclonal Antibody with Non-ionic Surfactant

description: Although we have made an extensive study of surface and interfacial adsorption of an engineered monoclonal antibody COE3, its solution structure has never been studied. As we know how COE3 is modified from the native IgG1, the proposed work here will lead to a better understanding of its conformation together with its constituting Fab and Fc in solution under different pHs. Then, we will examine how Fab, Fc and the whole mAb interact with modified Tween 80 with 7 and 13 EOs (PS80(7EO), PS80(13EO)). Preliminary studies have indicated that COE3 would interact with PS80(7EO) more favourably than the ones with longer EOs. Through appropriate contrast variations, SANS will help unravel the structural details relating to the binding of the nonionic surfactants to COE3 or its fragments. We will explore the new SASview based MD simulations for data analysis via support from the NIST team.
DOI: 10.5286/isis.e.rb2010375
title: The role of disorder on local structure and phase transitions in hybrid mixed-halide perovskites

description: Hybrid metal mixed-halide perovskites are promising materials for next generation high performance optoelectronic devices. Modification of the halide composition in these materials directly changes the optical bandgap. This makes them extremely attractive for the use in solar cells and light emitting diodes. It has been shown that hybrid perovskites are intrinsically heterogeneous, defective and dynamically disordered on a local scale. Despite the lack of understanding of their local structure in the scientific community, the optoelectronic performance of hybrid mixed-halide perovskites has steadily increased and currently rivals high purity crystalline semiconductors such as silicon. Local structure and disorder are directly correlated with the optoelectronic properties and stability, which makes their understanding and control crucial to achieve operational stability in devices.
DOI: 10.5286/isis.e.rb2010375-1
title: The role of disorder on local structure and phase transitions in hybrid mixed-halide perovskites

description: Hybrid metal mixed-halide perovskites are promising materials for next generation high performance optoelectronic devices. Modification of the halide composition in these materials directly changes the optical bandgap. This makes them extremely attractive for the use in solar cells and light emitting diodes. It has been shown that hybrid perovskites are intrinsically heterogeneous, defective and dynamically disordered on a local scale. Despite the lack of understanding of their local structure in the scientific community, the optoelectronic performance of hybrid mixed-halide perovskites has steadily increased and currently rivals high purity crystalline semiconductors such as silicon. Local structure and disorder are directly correlated with the optoelectronic properties and stability, which makes their understanding and control crucial to achieve operational stability in devices.
DOI: 10.5286/isis.e.rb2010375-2
title: The role of disorder on local structure and phase transitions in hybrid mixed-halide perovskites

description: Hybrid metal mixed-halide perovskites are promising materials for next generation high performance optoelectronic devices. Modification of the halide composition in these materials directly changes the optical bandgap. This makes them extremely attractive for the use in solar cells and light emitting diodes. It has been shown that hybrid perovskites are intrinsically heterogeneous, defective and dynamically disordered on a local scale. Despite the lack of understanding of their local structure in the scientific community, the optoelectronic performance of hybrid mixed-halide perovskites has steadily increased and currently rivals high purity crystalline semiconductors such as silicon. Local structure and disorder are directly correlated with the optoelectronic properties and stability, which makes their understanding and control crucial to achieve operational stability in devices.
DOI: 10.5286/isis.e.rb2010547
title: Impact of model contaminants on surface active marine coating addtives

description: Marine coatings are often based on silicone resins, with further additives to inhibit biofouling or enable release of adhered species. The efficiency of additives decreases with time and particularly with exposure to common contaminants, such as oils. We have started to explore this for model PDMS/additive systems by studying changes in surface property via dynamic contact angle. These experiments reveal dramatic changes in surface property upon exposure to hydrocarbon oil and we propose to use NR on simplified models to elucidate the molecular origins of this change in surface property. We postulate that alkane contaminants may promote surfactant leaching from PDMS film either by swelling the matrix (osmotic stress) or by compatibilising the additive, enabling it to diffuse out more easily. NR experiments will isolate these effects, so helping to formulate better marine coatings.
DOI: 10.5286/isis.e.rb2010547-1
title: Impact of model contaminants on surface active marine coating addtives

description: Marine coatings are often based on silicone resins, with further additives to inhibit biofouling or enable release of adhered species. The efficiency of additives decreases with time and particularly with exposure to common contaminants, such as oils. We have started to explore this for model PDMS/additive systems by studying changes in surface property via dynamic contact angle. These experiments reveal dramatic changes in surface property upon exposure to hydrocarbon oil and we propose to use NR on simplified models to elucidate the molecular origins of this change in surface property. We postulate that alkane contaminants may promote surfactant leaching from PDMS film either by swelling the matrix (osmotic stress) or by compatibilising the additive, enabling it to diffuse out more easily. NR experiments will isolate these effects, so helping to formulate better marine coatings.
DOI: 10.5286/isis.e.rb2010547-2
title: Impact of model contaminants on surface active marine coating addtives

description: Marine coatings are often based on silicone resins, with further additives to inhibit biofouling or enable release of adhered species. The efficiency of additives decreases with time and particularly with exposure to common contaminants, such as oils. We have started to explore this for model PDMS/additive systems by studying changes in surface property via dynamic contact angle. These experiments reveal dramatic changes in surface property upon exposure to hydrocarbon oil and we propose to use NR on simplified models to elucidate the molecular origins of this change in surface property. We postulate that alkane contaminants may promote surfactant leaching from PDMS film either by swelling the matrix (osmotic stress) or by compatibilising the additive, enabling it to diffuse out more easily. NR experiments will isolate these effects, so helping to formulate better marine coatings.
DOI: 10.5286/isis.e.rb2010547-3
title: Impact of model contaminants on surface active marine coating addtives

description: Marine coatings are often based on silicone resins, with further additives to inhibit biofouling or enable release of adhered species. The efficiency of additives decreases with time and particularly with exposure to common contaminants, such as oils. We have started to explore this for model PDMS/additive systems by studying changes in surface property via dynamic contact angle. These experiments reveal dramatic changes in surface property upon exposure to hydrocarbon oil and we propose to use NR on simplified models to elucidate the molecular origins of this change in surface property. We postulate that alkane contaminants may promote surfactant leaching from PDMS film either by swelling the matrix (osmotic stress) or by compatibilising the additive, enabling it to diffuse out more easily. NR experiments will isolate these effects, so helping to formulate better marine coatings.
DOI: 10.5286/isis.e.rb2010547-4
title: Impact of model contaminants on surface active marine coating addtives

description: Marine coatings are often based on silicone resins, with further additives to inhibit biofouling or enable release of adhered species. The efficiency of additives decreases with time and particularly with exposure to common contaminants, such as oils. We have started to explore this for model PDMS/additive systems by studying changes in surface property via dynamic contact angle. These experiments reveal dramatic changes in surface property upon exposure to hydrocarbon oil and we propose to use NR on simplified models to elucidate the molecular origins of this change in surface property. We postulate that alkane contaminants may promote surfactant leaching from PDMS film either by swelling the matrix (osmotic stress) or by compatibilising the additive, enabling it to diffuse out more easily. NR experiments will isolate these effects, so helping to formulate better marine coatings.
DOI: 10.5286/isis.e.rb2010176
title: Understanding the Stabilisation Mechanism of Light-Responsive Pickering Emulsions

description: This work aims to understand the mode-of-action of an emergent class of stimuli-responsive materials – Light-responsive Pickering emulsions. These are mixtures of oil and water where the oil is dispersed as droplets throughout the water and the boundary is stabilised by light-responsive solid particles. When UV light is shone on the particles, the droplets disperse, releasing their contents. This can be exploited for the delivery of drugs in the body, the separation of oil from water and the recovery of catalysts in industrial reactions. How the droplets disperse, however, is not well understood. Using spin-echo small angle neutron scattering, we aim to track changes in how the particles pack at the oil-water boundary during the destabilisation with UV light. This will allow us to tune the properties of the emulsions to better suit the varied requirements of the above applications.
DOI: 10.5286/isis.e.rb2010176-1
title: Understanding the Stabilisation Mechanism of Light-Responsive Pickering Emulsions

description: This work aims to understand the mode-of-action of an emergent class of stimuli-responsive materials – Light-responsive Pickering emulsions. These are mixtures of oil and water where the oil is dispersed as droplets throughout the water and the boundary is stabilised by light-responsive solid particles. When UV light is shone on the particles, the droplets disperse, releasing their contents. This can be exploited for the delivery of drugs in the body, the separation of oil from water and the recovery of catalysts in industrial reactions. How the droplets disperse, however, is not well understood. Using spin-echo small angle neutron scattering, we aim to track changes in how the particles pack at the oil-water boundary during the destabilisation with UV light. This will allow us to tune the properties of the emulsions to better suit the varied requirements of the above applications.
DOI: 10.5286/isis.e.rb2010176-2
title: Understanding the Stabilisation Mechanism of Light-Responsive Pickering Emulsions

description: This work aims to understand the mode-of-action of an emergent class of stimuli-responsive materials – Light-responsive Pickering emulsions. These are mixtures of oil and water where the oil is dispersed as droplets throughout the water and the boundary is stabilised by light-responsive solid particles. When UV light is shone on the particles, the droplets disperse, releasing their contents. This can be exploited for the delivery of drugs in the body, the separation of oil from water and the recovery of catalysts in industrial reactions. How the droplets disperse, however, is not well understood. Using spin-echo small angle neutron scattering, we aim to track changes in how the particles pack at the oil-water boundary during the destabilisation with UV light. This will allow us to tune the properties of the emulsions to better suit the varied requirements of the above applications.
DOI: 10.5286/isis.e.rb2010646
title: Evaluation of the Interaction of Propranolol Hydrochloride with Model Biomembranes

description: Surfactancy effects of poorly water soluble drugs are relatively unexplored compared with their primary mode of action involving membrane transporters. Specific drug interactions with certain lipids are understood to take place at much lower drug concentrations than are needed for their primary therapeutic effect. Our interest is to characterise the structure-function relationship of a series of structurally-related drugs – beta blockers. We have started to acquire surface pressure and ellipsometry data on the interactions of propranolol hydrochloride with model mammalian membranes. Now we require missing information from neutron reflectometry on the extent of interaction, degree of hydration and location of the drug in the model biomembranes. The data will provide the structural foundation for our project and contribute to our understanding of the role of drug-lipid interactions.
DOI: 10.5286/isis.e.rb2010646-1
title: Evaluation of the Interaction of Propranolol Hydrochloride with Model Biomembranes

description: Surfactancy effects of poorly water soluble drugs are relatively unexplored compared with their primary mode of action involving membrane transporters. Specific drug interactions with certain lipids are understood to take place at much lower drug concentrations than are needed for their primary therapeutic effect. Our interest is to characterise the structure-function relationship of a series of structurally-related drugs – beta blockers. We have started to acquire surface pressure and ellipsometry data on the interactions of propranolol hydrochloride with model mammalian membranes. Now we require missing information from neutron reflectometry on the extent of interaction, degree of hydration and location of the drug in the model biomembranes. The data will provide the structural foundation for our project and contribute to our understanding of the role of drug-lipid interactions.
DOI: 10.5286/isis.e.rb2010651
title: Self-assembly of the beta blocker, propranolol hydrochloride under physiological conditions

description: Some drug molecules are surface active and, as such, self-assemble into micellar structures when present above a concentration known as their critical micelle concentration (cmc), although there is evidence of pre-micellar aggregation with some drugs. What is not currently understood is whether this “surfactant-like” behaviour is important for the drug's therapeutic activity. As part of a larger study aimed at gaining insight into the structure-function relationship between a drug’s surface active nature and its therapeutic activity, we wish to perform contrast variation SANS experiments in order to understand how the conditions that the drug would encounter in the body might influence its aggregation behaviour. The results of this study will be combined with molecular dynamic studies.
DOI: 10.5286/isis.e.rb2010651-1
title: Self-assembly of the beta blocker, propranolol hydrochloride under physiological conditions

description: Some drug molecules are surface active and, as such, self-assemble into micellar structures when present above a concentration known as their critical micelle concentration (cmc), although there is evidence of pre-micellar aggregation with some drugs. What is not currently understood is whether this “surfactant-like” behaviour is important for the drug's therapeutic activity. As part of a larger study aimed at gaining insight into the structure-function relationship between a drug’s surface active nature and its therapeutic activity, we wish to perform contrast variation SANS experiments in order to understand how the conditions that the drug would encounter in the body might influence its aggregation behaviour. The results of this study will be combined with molecular dynamic studies.
DOI: 10.5286/isis.e.rb2010651-2
title: Self-assembly of the beta blocker, propranolol hydrochloride under physiological conditions

description: Some drug molecules are surface active and, as such, self-assemble into micellar structures when present above a concentration known as their critical micelle concentration (cmc), although there is evidence of pre-micellar aggregation with some drugs. What is not currently understood is whether this “surfactant-like” behaviour is important for the drug's therapeutic activity. As part of a larger study aimed at gaining insight into the structure-function relationship between a drug’s surface active nature and its therapeutic activity, we wish to perform contrast variation SANS experiments in order to understand how the conditions that the drug would encounter in the body might influence its aggregation behaviour. The results of this study will be combined with molecular dynamic studies.
DOI: 10.5286/isis.e.rb2010651-3
title: Self-assembly of the beta blocker, propranolol hydrochloride under physiological conditions

description: Some drug molecules are surface active and, as such, self-assemble into micellar structures when present above a concentration known as their critical micelle concentration (cmc), although there is evidence of pre-micellar aggregation with some drugs. What is not currently understood is whether this “surfactant-like” behaviour is important for the drug's therapeutic activity. As part of a larger study aimed at gaining insight into the structure-function relationship between a drug’s surface active nature and its therapeutic activity, we wish to perform contrast variation SANS experiments in order to understand how the conditions that the drug would encounter in the body might influence its aggregation behaviour. The results of this study will be combined with molecular dynamic studies.
DOI: 10.34740/kaggle/dsv/1988258
title: YouTube Trending Video Dataset (updated daily)
DOI: 10.5286/isis.e.rb2010448
title: Adsorption of Bispecific Therapeutic Monoclonal Antibodies at the Air/liquid Interface by NR

description: Following our previous neutron reflection study of interfacial adsorption of a bioengineered mAb called COE-3 and its fragments, the aim of this work is to determine how the two bioengineered bispecific mAbs (COE-7, COE-8) adsorb at the air/water interface against their concentrations, pH and ionic strength. As these two mAbs are highly modified, it is important to study how their adsorption is time-dependent under different concentrations and time so that these behaviours can be compared to the native mAb. We request Inter for following the dynamic changes by exploiting its high flux beam and the time event capability.
DOI: 10.5286/isis.e.rb2010448-1
title: Adsorption of Bispecific Therapeutic Monoclonal Antibodies at the Air/liquid Interface by NR

description: Following our previous neutron reflection study of interfacial adsorption of a bioengineered mAb called COE-3 and its fragments, the aim of this work is to determine how the two bioengineered bispecific mAbs (COE-7, COE-8) adsorb at the air/water interface against their concentrations, pH and ionic strength. As these two mAbs are highly modified, it is important to study how their adsorption is time-dependent under different concentrations and time so that these behaviours can be compared to the native mAb. We request Inter for following the dynamic changes by exploiting its high flux beam and the time event capability.
DOI: 10.7910/dvn/zkagak
title: Replication Data for: Ramping up a heuristic procedure for storage location assignment problem with precedence constraints

description: Data about products location and orders
DOI: 10.25919/wf27-5h88
title: Parkes observations for project P595 semester 2020OCTS_11

description: We propose to continue the PULSE@Parkes project in which high school students from Australia and around the World use the Parkes radio telescope in a remote observing model to observe and analyse pulsar data. The data from some PULSE@Parkes observations are used to support the FERMI Gamma ray mission, other observations supplement the P456 Pulsar Timing Array project and the remainder were chosen in order to make a detailed analysis of pulsar timing irregularities and intermittency.
DOI: 10.34777/7hxe-ny33
title: ELEA

description: The corpus was gathered with the aim of analyzing emergent leadership as a social phenomenon that occurs in newly formed groups. For each group in the corpus, the participants performed the winter survival task. The annotations of the corpus include self-reported and perceived personality, concepts related to leadership,  participants’ performance in the survival task, and manual transcriptions from the recordings in English. The full corpus contains approximately 10 hours of audio and video.
DOI: 10.15468/2qesm6
title: Additions to the knowledge on the genus Carinostigmus Tsuneki (Hymenoptera Crabronidae: Pemphredoninae) from the Indian subcontinent with the description of two new species

description: This dataset contains the digitized treatments in Plazi based on the original journal article Rajan, Tessy, Sureshan, P. M., Kumar, P. Girish (2020): Additions to the knowledge on the genus Carinostigmus Tsuneki (Hymenoptera Crabronidae: Pemphredoninae) from the Indian subcontinent with the description of two new species. Zootaxa 4881 (1): 152-164, DOI: https://doi.org/10.11646/zootaxa.4881.1.9
DOI: 10.6084/m9.figshare.13597781
title: Genes with GO:0006979 (response to oxidative stress) related annotation in meta-analyzed oxidative transcriptomes in D. melanogaster and C. elegans

description: Genes with GO:0006979 (response to oxidative stress) related annotation in meta-analyzed oxidative transcriptomes in D. melanogaster and C. elegans. For up/down regulated gene selection, over 10 fold threshold was adopted.