DOI: 10.7272/q61834nf
title: Targeted Cortical Reorganization using Optogenetics in Non-human primates: Electrocorticography in Sensorimotor Cortex during Optogenetic Stimulation

description: The data consists of electrocorticography (ECoG) recordings over primary
 somatosensory and primary motor cortices in two rhesus macaques that
 expressed C1V1 optogenetic channels in pyramidal neurons. The experimental
 setup, including the optogenetic expression and simultaneous ECoG and
 laser stimulation, are detailed in (Yazdan-Shahmorad et al., 2016).
   This dataset was collected during a series of ~1.5hr long
 experiments in which laser pulse trains were used to repeatedly stimulate
 one or two cortical sites. Each experiment was organized into blocks:
 Recording Blocks: Passive recordings were conducted during spontaneous
 activity (30 s or 5 min) Testing Blocks: 100 laser pulses were delivered
 with each laser, each in separate, interleaved blocks (10 pulses, 5ms @ 5
 or 7Hz). ECoG signals were recorded simultaneously. Conditioning Blocks:
 Laser pulses were delivered through each laser (5ms pulses @ 5 or 7Hz) for
 10min. The second laser had a fixed delay relative to the first laser and
 this delay varied across experiments. ECoG signals were recorded
 simultaneously. A single experiment consisted of a pre-test period, with a
 Recording Block (RB) and a Testing Block (TB), followed by 5 repetitions
 of a Conditioning Block (CB), RB, and TB, for a total of 6 TB and RB and 5
 CB: { RB TB - CB RB TB - CB RB TB - CB RB TB - CB RB TB - CB RB TB }
   Reference: YAZDAN-SHAHMORAD, A., DIAZ-BOTIA, C., HANSON, T. L.,
 KHARAZIA, V., LEDOCHOWITSCH, P., MAHARBIZ, M. M. & SABES, P. N.
 2016. A Large-Scale Interface for Optogenetic Stimulation and Recording in
 Nonhuman Primates. Neuron, 89, 927-39.  
description: <i>table_of_experiments.xlsx</i> contains some
 summary data for each experiment such as the number and timing of the
 lasers during the conditioning blocks.   Each experiment is
 self contained within a zip file:<i> Monkey_YYYYMMDD_
 Session#_PREAMP.zip</i> and each .zip file
 contains the following directories: ConditioningBlocks/ CondBlock1.mat CondBlock2.mat CondBlock3.mat CondBlock4.mat CondBlock5.mat RecordingBlocks/ RecBlock1.mat RecBlock2.mat RecBlock3.mat RecBlock4.mat RecBlock5.mat RecBlock6.mat TestingBlocks/ TestBlock1.mat TestBlock2.mat TestBlock3.mat TestBlock4.mat TestBlock5.mat TestBlock6.mat   Each Conditioning Block .mat file contains the following variables: <em>lfp_ch#</em> - broadband lfp signals for each channel # <em>hg_ch#</em> - high gamma filtered lfp signals for each channel # <em>time</em> - vector of time in seconds for each sample in <em>lfp_ch#</em> and <em>hg_ch#</em> <em>samp_freq</em> - sampling frequency for <em>lfp_ch#</em> and <em>hg_ch#</em> <em>stim1</em> - onset times of laser 1 pulses <em>stim2</em> - onset times of laser 2 pulses <em>tstart</em> - start time of conditioning block <em>tend</em> - end time of conditioning block   Each Recording Block .mat file contains the following variables <em>lfp_ch#</em> - broadband lfp signal for each channel # <em>time</em> - vector of time in seconds for each sample in <em>lfp_ch#</em> <em>samp_freq</em> - sampling frequency for <em>lfp_ch#</em> <em>tstart</em> - start time of recording block <em>tend</em> - end time of recording block   Each Testing Block .mat file contains the following variables <em>lfp_traces1_ch#</em> - broadband lfp signal aligned to laser1 pulse onsets for each channel # [pulses x time] <em>mean_lfp_traces1_ch#</em> - average broadband lfp signal aligned to laser1 pulse onsets for each channel # [pulses x time] <em>lfp_traces2_ch#</em> - broadband lfp signal aligned to laser2 pulse onsets for each channel # [pulses x time] <em>mean_lfp_traces2_ch#</em> - average broadband lfp signal aligned to laser2 pulse onsets for each channel # [pulses x time] <em>hg_traces1_ch#</em> - high gamma filtered lfp signal aligned to laser1 pulse onsets for each channel # [pulses x time] <em>mean_hg_traces1_ch#</em> - average high gamma filtered lfp signal aligned to laser1 pulse onsets for each channel # [pulses x time] <em>hg_traces2_ch#</em> - high gamma filtered lfp signal aligned to laser2 pulse onsets for each channel # [pulses x time] <em>mean_hg_traces2_ch#</em> - high gamma filtered lfp signal aligned to laser2 pulse onsets for each channel # [pulses x time] <em>samp_freq</em> - sampling frequency for lfp_ch# <em>stim1</em> - onset times of laser 1 pulses <em>stim2</em> - onset times of laser 2 pulses <em>tstart</em> - start time of recording block <em>tend</em> - end time of recording block <em>win</em> - window in seconds of data captured around the pulse onsets, ex. [1,1] represents a window that looks 1s back and 1s forward from the pulse onsets