cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.7937651.v2
title: Implementing Moran eigenvector spatial filtering for massively large georeferenced datasets

description: Moran eigenvector spatial filtering (MESF) furnishes an alternative method to account for spatial autocorrelation in linear regression specifications describing georeferenced data, although spatial auto-models also are widely used. The utility of this MESF methodology is even more impressive for the non-Gaussian models because its flexible structure enables it to be easily applied to generalized linear models, which include Poisson, binomial, and negative binomial regression. However, the implementation of MESF can be computationally challenging, especially when the number of geographic units, <i>n</i>, is large, or massive, such as with a remotely sensed image. This intensive computation aspect has been a drawback to the use of MESF, particularly for analyzing a remotely sensed image, which can easily contain millions of pixels. Motivated by Curry, this paper proposes an approximation approach to constructing eigenvector spatial filters (ESFs) for a large spatial tessellation. This approximation is based on a divide-and-conquer approach. That is, it constructs ESFs separately for each sub-region, and then combines the resulting ESFs across an entire remotely sensed image. This paper, employing selected specimen remotely sensed images, demonstrates that the proposed technique provides a computationally efficient and successful approach to implement MESF for large or massive spatial tessellations.
DOI: 10.6084/m9.figshare.7937651.v1
title: Implementing Moran eigenvector spatial filtering for massively large georeferenced datasets

description: Moran eigenvector spatial filtering (MESF) furnishes an alternative method to account for spatial autocorrelation in linear regression specifications describing georeferenced data, although spatial auto-models also are widely used. The utility of this MESF methodology is even more impressive for the non-Gaussian models because its flexible structure enables it to be easily applied to generalized linear models, which include Poisson, binomial, and negative binomial regression. However, the implementation of MESF can be computationally challenging, especially when the number of geographic units, <i>n</i>, is large, or massive, such as with a remotely sensed image. This intensive computation aspect has been a drawback to the use of MESF, particularly for analyzing a remotely sensed image, which can easily contain millions of pixels. Motivated by Curry, this paper proposes an approximation approach to constructing eigenvector spatial filters (ESFs) for a large spatial tessellation. This approximation is based on a divide-and-conquer approach. That is, it constructs ESFs separately for each sub-region, and then combines the resulting ESFs across an entire remotely sensed image. This paper, employing selected specimen remotely sensed images, demonstrates that the proposed technique provides a computationally efficient and successful approach to implement MESF for large or massive spatial tessellations.
DOI: 10.6084/m9.figshare.7937585
title: Supplementary Material for: Abdominal Displacement Ventilation: An Effective Intervention for Sedation-Induced Hypoxia

description: <b><i>Background:</i></b> Sedation for bronchoscopy at times causes hypoxia. The application of positive pressure ventilation for sedation-induced hypoxia often requires cessation of the bronchoscopy. In contrast, ventilation effected via cyclical abdominal compression, if effective, would allow bronchoscopy to proceed. Initial trials of abdominal displacement ventilation (ADV) proved successful. This report documents extended experience with ADV. <b><i>Objective:</i></b> To evaluate and report the efficacy and applicability of ADV in the setting of sedation-induced hypoxia for consecutive patients over an extended interval. <b><i>Methods:</i></b> Based upon its initial efficacy, ADV had been incorporated into the standard approach to sedation-induced hypoxia. We retrospectively reviewed all bronchoscopies performed by interventional pulmonary over a 12-month interval. Management and efficacy of every episode of sedation-induced hypoxia were documented. <b><i>Results:</i></b> Over the study interval, 893 bronchoscopies had been performed, with sedation-induced hypoxia occurring in 38 (4%). ADV was possible in 37 of the 38 patients. In every case, ADV was effective and allowed completion of the procedure. There were no adverse effects. <b><i>Conclusion:</i></b> ADV is a simple, effective, noninvasive approach to sedation-induced hypoxia that effects adequate ventilation and allows safe continuance of procedures.
DOI: 10.6084/m9.figshare.7937603
title: gVCF_NA20505

description: 1000 Genomes gVCF mapped to hs37d5 for NA20505. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7937606
title: At what stage in the undergraduate curriculum is it best to train in family medicine? A study from two medical schools in Spain

description: <b>Background:</b> A course in family medicine (FM) could dispel the possibility of negative stereotyping about this speciality, and instil in students a greater interest. However, when is it preferable: at the beginning or at the end of undergraduate training? <b>Objectives:</b> To determine changes in knowledge and attitudes towards FM by medical students completing a course in primary care at the beginning or the end of the undergraduate training and whether those changes anticipate the choice of speciality. <b>Methods:</b> Students from Albacete and Seville medical schools (primary care course in second and sixth years, respectively) were asked to respond to the ‘valuation of attitudes towards and knowledge of family medicine questionnaire’ (CAMF). Students from Albacete answered before and after the course, and in Seville second-year students answered at the end of the first trimester. All students were invited to respond again at the end of their undergraduate training. Afterwards, we investigated the score on the speciality exam (order for the election from highest to lowest score) and their choice of speciality. The outcome measures were the MIR exam score, the number in the ranking, the chosen speciality and the result of the CAMF. <b>Results:</b> In Albacete 88 and 64 and in Seville 50 and 98 students responded in their second and sixth years, respectively. In Albacete, mean CAMF scores were 15.4, 22.7 before and after the course, and 21.8 at the end while in Seville, 13.9 in the second year, and 23.5 in the sixth year. Logistic regression analysis showed an association of the choice of FM only with the score on the speciality exam (OR: 0.667; 95%CI: 0.553–0.806). <b>Conclusion:</b> There were no significant differences between CAMF scores at the end of undergraduate training. Only the score on the speciality exam predicts FM choice: the higher the score, the lower the probability of choosing FM.
DOI: 10.6084/m9.figshare.7937606.v1
title: At what stage in the undergraduate curriculum is it best to train in family medicine? A study from two medical schools in Spain

description: <b>Background:</b> A course in family medicine (FM) could dispel the possibility of negative stereotyping about this speciality, and instil in students a greater interest. However, when is it preferable: at the beginning or at the end of undergraduate training? <b>Objectives:</b> To determine changes in knowledge and attitudes towards FM by medical students completing a course in primary care at the beginning or the end of the undergraduate training and whether those changes anticipate the choice of speciality. <b>Methods:</b> Students from Albacete and Seville medical schools (primary care course in second and sixth years, respectively) were asked to respond to the ‘valuation of attitudes towards and knowledge of family medicine questionnaire’ (CAMF). Students from Albacete answered before and after the course, and in Seville second-year students answered at the end of the first trimester. All students were invited to respond again at the end of their undergraduate training. Afterwards, we investigated the score on the speciality exam (order for the election from highest to lowest score) and their choice of speciality. The outcome measures were the MIR exam score, the number in the ranking, the chosen speciality and the result of the CAMF. <b>Results:</b> In Albacete 88 and 64 and in Seville 50 and 98 students responded in their second and sixth years, respectively. In Albacete, mean CAMF scores were 15.4, 22.7 before and after the course, and 21.8 at the end while in Seville, 13.9 in the second year, and 23.5 in the sixth year. Logistic regression analysis showed an association of the choice of FM only with the score on the speciality exam (OR: 0.667; 95%CI: 0.553–0.806). <b>Conclusion:</b> There were no significant differences between CAMF scores at the end of undergraduate training. Only the score on the speciality exam predicts FM choice: the higher the score, the lower the probability of choosing FM.
DOI: 10.6084/m9.figshare.7937603.v1
title: gVCF_NA20505

description: 1000 Genomes gVCF mapped to hs37d5 for NA20505. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7937570
title: gVCF_HG02724

description: 1000 Genomes gVCF mapped to hs37d5 for HG02724. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7937570.v1
title: gVCF_HG02724

description: 1000 Genomes gVCF mapped to hs37d5 for HG02724. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7937561
title: gVCF_NA12005

description: 1000 Genomes gVCF mapped to hs37d5 for NA12005. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7937564
title: gVCF_NA20504

description: 1000 Genomes gVCF mapped to hs37d5 for NA20504. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7937561.v1
title: gVCF_NA12005

description: 1000 Genomes gVCF mapped to hs37d5 for NA12005. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7937564.v1
title: gVCF_NA20504

description: 1000 Genomes gVCF mapped to hs37d5 for NA20504. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7937465
title: Aluminum in liver cells – the element species matters

description: Aluminum (Al) can be ingested from food and released from packaging and can reach key organs involved in human metabolism, including the liver via systemic distribution. Recent studies discuss the occurrence of chemically distinct Al-species and their interconversion by contact with biological fluids. These Al species can vary with regard to their intestinal uptake, systemic transport, and therefore could have species-specific effects on different organs and tissues. This work aims to assess the <i>in vitro</i> hepatotoxic hazard potential of three different relevant Al species: soluble AlCl<sub>3</sub> and two nanoparticulate Al species were applied, representing for the first time an investigation of metallic nanoparticles besides to mineral bound γ-Al<sub>2</sub>O<sub>3</sub> on hepatic cell lines. To investigate the uptake and toxicological properties of the Al species, we used two different human hepatic cell lines: HepG2 and differentiated HepaRG cells. Cellular uptake was determined by different methods including light microscopy, transmission electron microscopy, side-scatter analysis, and elemental analysis. Oxidative stress, mitochondrial dysfunction, cell death mechanisms, and DNA damage were monitored as cellular parameters. While cellular uptake into hepatic cell lines occurred predominantly in the particle form, only ionic AlCl<sub>3</sub> caused cellular effects. Since it is known, that Al species can convert one into another, and mechanisms including ‘trojan-horse’-like uptake can lead to an Al accumulation in the cells. This could result in the slow release of Al ions, for which reason further hazard cannot be excluded. Therefore, individual investigation of the different Al species is necessary to assess the toxicological potential of Al particles.
DOI: 10.6084/m9.figshare.7937465.v1
title: Aluminum in liver cells – the element species matters

description: Aluminum (Al) can be ingested from food and released from packaging and can reach key organs involved in human metabolism, including the liver via systemic distribution. Recent studies discuss the occurrence of chemically distinct Al-species and their interconversion by contact with biological fluids. These Al species can vary with regard to their intestinal uptake, systemic transport, and therefore could have species-specific effects on different organs and tissues. This work aims to assess the <i>in vitro</i> hepatotoxic hazard potential of three different relevant Al species: soluble AlCl<sub>3</sub> and two nanoparticulate Al species were applied, representing for the first time an investigation of metallic nanoparticles besides to mineral bound γ-Al<sub>2</sub>O<sub>3</sub> on hepatic cell lines. To investigate the uptake and toxicological properties of the Al species, we used two different human hepatic cell lines: HepG2 and differentiated HepaRG cells. Cellular uptake was determined by different methods including light microscopy, transmission electron microscopy, side-scatter analysis, and elemental analysis. Oxidative stress, mitochondrial dysfunction, cell death mechanisms, and DNA damage were monitored as cellular parameters. While cellular uptake into hepatic cell lines occurred predominantly in the particle form, only ionic AlCl<sub>3</sub> caused cellular effects. Since it is known, that Al species can convert one into another, and mechanisms including ‘trojan-horse’-like uptake can lead to an Al accumulation in the cells. This could result in the slow release of Al ions, for which reason further hazard cannot be excluded. Therefore, individual investigation of the different Al species is necessary to assess the toxicological potential of Al particles.
DOI: 10.6084/m9.figshare.7937450
title: Supplementary Material for: Evaluation of the Associations between Gastric Tube Preparation Methods and the Incidence of Cervical Anastomotic Leakage after Esophagectomy for Thoracic Esophageal Cancer

description: <b><i>Background:</i></b> A gastric tube (GT) is most often selected as a reconstruction conduit in esophageal reconstruction. Although some leakage from esophagogastric anastomoses is induced by blood flow failure in reconstruction conduits, the association between the GT and the anastomotic leakage (AL) is unclear. <b><i>Objectives:</i></b> We retrospectively evaluated the incidence of AL according to the GT shape. <b><i>Methods:</i></b> Between February 2013 and September 2017, 188 consecutive patients who underwent esophagectomy with GT reconstruction were enrolled in this cohort study. We performed GT reconstruction using a narrow GT (Gr.N) until May 2016. Subsequently, we began preparing and using a stretched GT (Gr.S). <b><i>Results:</i></b> AL occurred in 29 of 188 (15.4%) patients. The frequency of AL was lower with Gr.S than with Gr.N (<i>p</i> = 0.034). Sex, body mass index, Brinkman index, hypertension, and anemia were significantly associated with AL (<i>p</i> = 0.033, 0.041, 0.003, 0.030, and 0.042, respectively). In a multivariate logistic regression analysis, the GT shape and the Brinkman index were shown to be independent risk factors for AL (<i>p</i> = 0.016 and 0.020, respectively). <b><i>Conclusions:</i></b> The GT preparation method is an independent risk factor for AL after cervical esophagogastrostomy. Thus, improved GT preparation methods could contribute to the reduction of AL after esophagectomy.
DOI: 10.6084/m9.figshare.7937453
title: gVCF_HG02722

description: 1000 Genomes gVCF mapped to hs37d5 for HG02722. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7937450.v1
title: Supplementary Material for: Evaluation of the Associations between Gastric Tube Preparation Methods and the Incidence of Cervical Anastomotic Leakage after Esophagectomy for Thoracic Esophageal Cancer

description: <b><i>Background:</i></b> A gastric tube (GT) is most often selected as a reconstruction conduit in esophageal reconstruction. Although some leakage from esophagogastric anastomoses is induced by blood flow failure in reconstruction conduits, the association between the GT and the anastomotic leakage (AL) is unclear. <b><i>Objectives:</i></b> We retrospectively evaluated the incidence of AL according to the GT shape. <b><i>Methods:</i></b> Between February 2013 and September 2017, 188 consecutive patients who underwent esophagectomy with GT reconstruction were enrolled in this cohort study. We performed GT reconstruction using a narrow GT (Gr.N) until May 2016. Subsequently, we began preparing and using a stretched GT (Gr.S). <b><i>Results:</i></b> AL occurred in 29 of 188 (15.4%) patients. The frequency of AL was lower with Gr.S than with Gr.N (<i>p</i> = 0.034). Sex, body mass index, Brinkman index, hypertension, and anemia were significantly associated with AL (<i>p</i> = 0.033, 0.041, 0.003, 0.030, and 0.042, respectively). In a multivariate logistic regression analysis, the GT shape and the Brinkman index were shown to be independent risk factors for AL (<i>p</i> = 0.016 and 0.020, respectively). <b><i>Conclusions:</i></b> The GT preparation method is an independent risk factor for AL after cervical esophagogastrostomy. Thus, improved GT preparation methods could contribute to the reduction of AL after esophagectomy.
DOI: 10.6084/m9.figshare.7937453.v1
title: gVCF_HG02722

description: 1000 Genomes gVCF mapped to hs37d5 for HG02722. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7937444
title: gVCF_NA20503

description: 1000 Genomes gVCF mapped to hs37d5 for NA20503. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7937447
title: Occurrence point data from: "The current and future global distribution and population at risk of dengue"

description: Includes all the dengue data used in the paper "The current and future global distribution and population at risk of dengue, 2019 Nature Microbiology: https://doi.org/10.1038/s41564-019-0476-8" which provides further information on its generation and use in mapping the current and future global distribution of dengue.<br><br><br>Three datasets are included:<br>1. Dengue occurence point dataset: "points_standard_checkedEC.csv" which contains precise point locations where dengue has occurrence in the past<br>2. Dengue occurrence polygon dataset: "poly_standard_checkedEC.csv" which contains small administrative units in within which dengue has occurred in the past<br>3. Other disease background points:"dengue_background_full.csv" which contains point locations where other non-dengue infectious diseases have occurred in the past<br>The fillets have a number of common field names including:unique IDcalendar yearAdministrative level (1 = first administrative level e.g. state in USA, 2 = second administrative level e.g. county in USA), Longitude (of polygon centroid for polygon data)Latitude (of polygon centroid for polygon data)Area (in square km) of the administrative unit the point falls within or the administrative unit that the polygon belongs to<br>
DOI: 10.6084/m9.figshare.7937444.v1
title: gVCF_NA20503

description: 1000 Genomes gVCF mapped to hs37d5 for NA20503. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7937429
title: gVCF_NA12004

description: 1000 Genomes gVCF mapped to hs37d5 for NA12004. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7937447.v1
title: Occurrence point data from: "The current and future global distribution and population at risk of dengue"

description: Includes all the dengue data used in the paper "The current and future global distribution and population at risk of dengue, 2019 Nature Microbiology: https://doi.org/10.1038/s41564-019-0476-8" which provides further information on its generation and use in mapping the current and future global distribution of dengue.<br><br><br>Three datasets are included:<br>1. Dengue occurence point dataset: "points_standard_checkedEC.csv" which contains precise point locations where dengue has occurrence in the past<br>2. Dengue occurrence polygon dataset: "poly_standard_checkedEC.csv" which contains small administrative units in within which dengue has occurred in the past<br>3. Other disease background points:"dengue_background_full.csv" which contains point locations where other non-dengue infectious diseases have occurred in the past<br>The fillets have a number of common field names including:unique IDcalendar yearAdministrative level (1 = first administrative level e.g. state in USA, 2 = second administrative level e.g. county in USA), Longitude (of polygon centroid for polygon data)Latitude (of polygon centroid for polygon data)Area (in square km) of the administrative unit the point falls within or the administrative unit that the polygon belongs to<br>
DOI: 10.6084/m9.figshare.7937417
title: The relevant dataes of "Therapeutic effect of vasoactive intestinal peptide on form-deprived amblyopic kittens"

description: The relevant dataes of "Therapeutic effect of vasoactive intestinal peptide on form-deprived amblyopic kittens"
DOI: 10.6084/m9.figshare.7937426
title: Effect of Temperature and Relative Humidity on Growth of <i>Aspergillus</i> and <i>Penicillium</i> spp. and Biocontrol Activity of <i>Pseudomonas protegens</i> AS15 against Aflatoxigenic <i>Aspergillus flavus</i> in Stored Rice Grains

description: In this study, we evaluated the effect of different temperatures (10, 20, 30, and 40 °C) and relative humidities (RHs; 12, 44, 76, and 98%) on populations of predominant grain fungi (<i>Aspergillus candidus</i>, <i>Aspergillus flavus</i>, <i>Aspergillus fumigatus</i>, <i>Penicillium fellutanum</i>, and <i>Penicillium islandicum</i>) and the biocontrol activity of <i>Pseudomonas protegens</i> AS15 against aflatoxigenic <i>A. flavus</i> KCCM 60330 in stored rice. Populations of all the tested fungi in inoculated rice grains were significantly enhanced by both increased temperature and RH. Multiple linear regression analysis revealed that one unit increase of temperature resulted in greater effects than that of RH on fungal populations. When rice grains were treated with <i>P. protegens</i> AS15 prior to inoculation with <i>A. flavus</i> KCCM 60330, fungal populations and aflatoxin production in the inoculated grains were significantly reduced compared with the grains untreated with strain AS15 regardless of temperature and RH (except 12% RH for fungal population). In addition, bacterial populations in grains were significantly enhanced with increasing temperature and RH, regardless of bacterial treatment. Higher bacterial populations were detected in biocontrol strain-treated grains than in untreated control grains. To our knowledge, this is the first report showing consistent biocontrol activity of <i>P. protegens</i> against <i>A. flavus</i> population and aflatoxin production in stored rice grains under various environmental conditions of temperature and RH.
DOI: 10.6084/m9.figshare.7937429.v1
title: gVCF_NA12004

description: 1000 Genomes gVCF mapped to hs37d5 for NA12004. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7937417.v1
title: The relevant dataes of "Therapeutic effect of vasoactive intestinal peptide on form-deprived amblyopic kittens"

description: The relevant dataes of "Therapeutic effect of vasoactive intestinal peptide on form-deprived amblyopic kittens"
DOI: 10.6084/m9.figshare.7937411
title: gVCF_NA20502

description: 1000 Genomes gVCF mapped to hs37d5 for NA20502. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307