cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.28229900.v1
title: Supplementary Material for: Unusual presentation of a rare case of immunotherapy combination induced encephalitis: A case report

description: Introduction Immune checkpoint inhibitors have revolutionized cancer treatment owing to their ability to activate cellular immune checkpoint pathways and mediate an anti-tumor activity. Due to their immunological actions, immune-related adverse events (irAEs) have become a concern. Neurological adverse events are rarely seen whether in the central or peripheral nervous system and can be potentially life-threatening. We present a rare case of occipital encephalitis following dual immunotherapy treatment in a patient with melanoma.
Case Report A 41 year old man diagnosed with nodular melanoma of the right torso with axillary lymphadenopathies was treated with dual immunotherapy: nivolumab and ipilimumab. After 24 weeks, patient developed right homolateral hemianopia, imaging findings correlated with occipital encephalitis. Auto-antibodies were not detected. The patient was treated with steroids and exhibited radiological improvement of his encephalitis but maintained his right hemianopia.
Conclusion Neurological side effects of immunotherapy are not very common and range from mild to severe life threatening symptoms. Previous analyses have shown that combination immunotherapy has a higher risk of side effects than monotherapy. Diagnosis of neurological manifestations is usually made by imaging, mainly brain magnetic resonance imaging (MRI), or detection of auto-antibodies in the CSF. The gold standard treatment is usually corticosteroids or rarely other molecules such as IVIg or monoclonal antibodies. The prognosis is usually favorable.
DOI: 10.6084/m9.figshare.28340381.v2
title: Aiello_XRF_Elkhorn Slough_data.pdfThis report contains a subset of preliminary elemental data collected in the Elkhorn Slough wetlands using a portable X-ray Fluorescence detector (XRF) in July 2023 and January 2025 after the after the Vistra Power Plant's lithium-ion battery storage facility fire.

description: This report contains a subset of preliminary elemental data collected in the Elkhorn Slough wetlands using a portable X-ray Fluorescence detector (XRF). The XRF measurements were re-taken by Dr. Aiello with the same instrument in the same quadrats in the days after the Vistra Power Plant's lithium-ion battery storage facility fire. Here, data from a subset of these quadrats is shown to illustrate both the spatial variation and the overall increase in likely battery-associated metals.
DOI: 10.6084/m9.figshare.5328628.v2
title: File S1 from Bird and bat species' global vulnerability to collision mortality at wind farms revealed through a trait-based assessment.

description: Collision dataset and list of references reviewed.
DOI: 10.6084/m9.figshare.6844505.v1
title: Supplementary Material for: The Anaphylatoxin C3a Receptor Expression on Human M2 Macrophages Is Down-Regulated by Stimulating the Histamine H4 Receptor and the IL-4 Receptor

description: The anaphylatoxin C3a triggers inflammation by binding to its specific G-protein-coupled C3a receptor (C3aR). Since the number of C3aR, which is expressed on the cell surface, affects the response to C3a, we investigated the expression levels of C3aR on human M2 macrophages in allergic situations where high levels of the Th2 cytokine IL-4 and histamine are present in a local microenvironment. The histamine H1 receptor (H1R), H2R and the H4R mRNA expressions were induced or up-regulated during the differentiation process of M2 macrophages. The presence of histamine or agonists targeting the H1R, H2R and, in particular, the H4R during in vitro differentiation from monocytes to macrophages modified the M2 phenotype by regulating the macrophage differentiation marker CD68 and CD163 expressions. In ­addition, the C3aR expression was also down-regulated by ­ST-1006 during this process. Histamine and ST-1006 down-regulated the expression of C3aR with different time kinetics on fully differentiated M2 macrophages. By analysing C3a-induced IL-6 mRNA expression, we observed a diminished response to C3a in ST-1006-treated M2 macrophages when compared to un-treated cells. Expression of C3 was not affected by histamine, whereas IL-4 strongly down-regulated C3aR and C3 expressions. Our data suggests that down-regulation of C3aR expression by mediators present in allergic situations such as IL-4 or histamine has an anti-inflammatory impact by reducing the sensitivity to C3a-induced down-stream signaling, thereby contributing to the regulation of local inflammatory responses in the skin.
DOI: 10.6084/m9.figshare.9275156.v1
title: Quantitation of stereocilia dimensions during C57BL/6 development

description: For analyzing length and width of apical IHC stereocilia during development, z-stack images of phalloidin-stained IHC stereocilia from cochleas of C57BL/6J mice were obtained using identical image acquisition parameters. Images were acquired on a ZEISS Elyra PS.1/LSM 710 Airyscan combination setup, using a 63x 1.4 NA Plan-Apochromat or a 100x 1.46 NA alpha Plan-Apochromat lens, integrated under ZEN 2.1 software. Raw data processing for Airyscan-acquired images was performed using manufacturer-implemented automated settings. At least 2-4 cochleas were used for developmental ages E18.5 (embryonic), P0.5, P4.5, P7.5, P10.5, P12.5, P15.5, P19.5 (post-natal). For each developmental age, images containing hair bundles that were upright were selected for generating x-z reslices (Fig. S1C) of stereocilia with the ‘Reslice’ function in Fiji. Reslices were chosen with views of stereocilia rows 1 and 2; we chose central stereocilia in most bundles. Stereocilia lengths were measured individually in Fiji by manually drawing a vertical line from the top of a stereocilium to the point of insertion in the cuticular plate. For measuring stereocilia widths, horizontal lines were manually drawn at 50% of the bundle height for both rows 1 and 2.
DOI: 10.17632/py4vr4wv2j
title: Do sexual differences in life strategies make male lizards more susceptible to parasite infection?

description: 1. Female and male hosts may maximise their fitness by differential evolution of strategies that compensate for the costs of parasite infections. The resulting sexual dimorphism might be apparent in differential relationships between parasite load and body condition, potentially reflecting differences in energy allocation to anti-parasitic defences. For example, male lacertids with high body condition may produce many offspring while being intensely parasitised. In contrast, female lacertids may express a different outcome of the trade-offs between body condition and immunity, aiming to better protect themselves from the harm of parasites.

2. We predicted that females would have fewer parasites than males and a lower body condition across parasitaemia levels, because they would invest resources into parasite defence to mitigate the costs of infection. In contrast, the male strategy to maximise access to females would imply some level of parasite tolerance and, thus, higher parasitaemia.

3. We analysed the relationship between body condition of lizards and parasitaemias of Karyolysus and Schellackia, two genera of blood parasites with different phylogenetic origin, in 565 females and 899 males belonging to 10 species of the Lacertidae (Squamata) that were sampled during a period of 12 years across 34 sampling sites in southwestern Europe.

4. The results concerning the Karyolysus infections were consistent with the predictions, with males having similar body condition across parasitaemia levels even though they had higher infection intensities than females. On the other hand, females with higher levels of Karyolysus parasitaemia had lower body condition. This is consistent with the prediction that different life strategies of male and female lacertids can explain the infection patterns of Karyolysus. In contrast, the parasitaemia of Schellackia was consistently low in both male and female hosts, with no significant effect on body condition of lizards, suggesting that lizards of both sexes maintain this parasite bellow a pathogenic threshold.
DOI: 10.17632/r77nc3ft87
title: Data on performance and variation index for shield tunnelling through soft deposit

description: The data pertain to field records of EPB shield machine in Metro Line No.5 in Tianjin, China. Field performance of shield machine (cutterhead, screw machine, and shield advancing) are shown in the file. Specifically, the database consists of the main parameters for shield tunnelling including cutterhead rotation speed, cutterhead torque, screw machine rotation speed, screw machine torque, shield thrust, and shield advance rate. In addition, the calculation process of energy consumption and variation index during the tunnelling are displayed. The value of the dataset is the consideration of silt or clay soil encountered in the shield tunnelling area including the proportion of soils, grain gradation, and effects on performance and energy consumption of different parts in shield machine.
DOI: 10.17632/xgyt8fhgps
title: Drug-Food Interactions

description: This data contains a list of drug-food interactions.
DOI: 10.6084/m9.figshare.21994745.v1
title: Economic Complexity Index: NUTS-3 - Turkey (2007-2020)

description: This study employs the Economic Complexity Index (ECI) and the Economic Fitness Index (EFI) as two different measures of economic complexity. The ECI is based on the methodology developed by Hausmann et al. (2014b), while the EFI was introduced by Tacchella et al. (2012) and later improved by Servedio et al. (2018) and Operti et al. (2018). We used the International Trade Database at the Product Level (BACI) to determine global product complexities. The BACI dataset includes detailed export data for over 200 countries and territories. To ensure accuracy and eliminate fluctuations in export data, Hidalgo (2021) recommends excluding countries with exports of less than 1 billion US dollars, countries with a population of less than 1 million, and products with a global export value of less than 500 million US dollars from the dataset. To avoid endogeneity issues, we followed Boschma et al. (2013) and excluded Turkey from the sample. After cleaning the data in accordance with Hidalgo (2021) and Boschma et al. (2013), we calculated global product complexities for 124 to 141 countries from 2007 to 2020. Since foreign trade statistics of provinces obtained from TURKSTAT are classified according to Standard International Trade Classification (SITC revision 3) at 4-digit codes, we converted BACI dataset based on Harmonized System (HS) classification using Eurostat Metadata Server (RAMON) conversion tables. <br> <strong>Variables:</strong> <em>countrycode</em>: NUTS-3 codes of provinces <em>country</em>: Provinces <em>id</em>: identification numbers (given by the authors) <em>gdpper</em>: Real GDP per capita. <em>dist</em>: Distance of provinces from Istanbul in kilometers <em>eci</em>: Economic Complexity Index (Hidalgo et al. 2014) <em>fit</em>: Economic Fitness Index (Tacchella et al. 2012, Servedio et a. 2018, Operti et al. 2018). <em>ind_elec_cons</em>: Ratio of industrial electricity consumption to total electricity consumption. <em>education</em>: Percentage of high school, faculty, master, and doctorate graduates in the population aged 15 and over. <em>reer</em>: Real Effective Exchange Rate. <em>openness</em>: Share of province-level exports and imports on total provincial GDP. <em>ethnicity:</em> is calculated as the average of the votes received by Kurdish political parties in the provinces. <em>secim</em>: An alternative for ethnicity. Calculated as the the ratio of the number of municipalities won by Kurdish political party mayoral candidates to the total number of municipalities in each province. <em>East</em>: A dummy variable for the provinces located to the east of the capital city, Ankara, are considered as eastern provinces and are labeled as 1, while the provinces located to the west are labeled as 0 and considered as western provinces. <em>onuc</em>: A dummy variable for 13 provinces that are in the scope of cross-border trade regulation are labeled as 1. <br>
DOI: 10.6084/m9.figshare.22591438.v1
title: [Input data] High-resolution long-term average groundwater recharge in Africa estimated using random forest regression and residual interpolation

description: Input predictor datasets for LTA groundwater recharge maps (doi: 10.6084/m9.figshare.22591375), derived from previously published material are provided at both spatial resolutions 0.5<strong>°</strong> and 0.1<strong>°</strong> for: climate data, soil moisture and the normalized difference vegetation index (NDVI).
DOI: 10.6084/m9.figshare.29198612.v1
title: Lock Shape Design – Public Disclosure

description: <b>Title:</b> Lock Shape Design – Public Disclosure<br><b>Author:</b> Alex Tóth<br><b>Date:</b> 30 May 2025This design is hereby publicly disclosed by the author for the purpose of placing it in the <b>public domain</b> and establishing <b>prior art</b>.<br>No exclusive intellectual property rights are claimed.<br>Any attempt to register this design as new or original in any jurisdiction after this disclosure date shall lack novelty and may be invalid.<b>Intended use</b>: illustrative component of broader design concepts (e.g., MycoNest, Pomaris).<br>This disclosure serves as a <b>defensive publication</b> to ensure <b>freedom to operate</b>.
DOI: 10.6084/m9.figshare.8079944.v1
title: Code and summary results for: Discovering cross-reactivity in urine drug screening immunoassays through large-scale analysis of electronic health records

description: Zip file contains parameter and metadata files, data from spiking experiments, sql and R scripts, and results in the form of figures and csv files.
DOI: 10.17632/x2fn4xdbpy
title: Supplementary Table 1. Equations used to predict finishing performance and carcass characteristics

description: Equations used to estimate adjusted final shrunk BW (AFS-BW), shrunk weight gain (SWG), empty body weight (EBW), empty body composition of fat (EBF), individual DMI, feed efficiency (G:F), and days on feed to reach 28% EBF during the finishing period.
DOI: 10.6084/m9.figshare.10264427.v1
title: MOESM3 of Genome-wide expression profiling in colorectal cancer focusing on lncRNAs in the adenoma-carcinoma transition

description: Additional file 3: Table S2. In silico validation on independent datasets.
DOI: 10.6084/m9.figshare.13077149.v1
title: Body image and social media study data.sav

description: The present study sought to investigate the magnitude of body image dissatisfaction (BID) among adolescent athletes in Sri Lanka and to explore its relationship with selected activities on social media. A total of 478 adolescents (53.7% male), aged 13 to 19 years, who were currently engaged in athletics, were recruited. BID was assessed using the Adolescent Body Image Satisfaction Scale. Time spent on social media, and the frequency of selfie-taking, selfie-posting and photo manipulation were assessed using ordinal scales. Weight and height were measured and body mass index was calculated. In the sample, 51.3% were reportedly active on social media. Social media use was higher among boys and older adolescents. While 20.9% of the adolescents articulated a positive body image, almost all the others (78.7%) reported mild BID. Higher body mass index was associated with greater BID, after adjusting for age and gender. Gender and age were not significant predictors of body image concerns. Among the social media activity parameters, only selfie-taking frequency was positively correlated with BID. Photo manipulation was significantly associated with body image concerns, only among girls.
DOI: 10.6084/m9.figshare.27332478.v1
title: Anonymized replication data for: Smart manufacturing systems and industry 4.0 technologies

description: Anonymized replication data for: Smart manufacturing systems and industry 4.0 technologies
DOI: 10.6084/m9.figshare.27959469.v3
title: Datasets and Code for the paper

description: The dataset comprises raw text files obtained through motion energy analysis, as well as the final Excel table of variables and the code for statistical analysis.<br><br>Upd. A mistake was found when calculating MEA. In this version it is fixed and also some new sessions MEA results are added.Upd2. Corrected xlsx tables (heterogeneous and homogeneous) and R code are added.
DOI: 10.6084/m9.figshare.28921175.v1
title: Supplementary Material for: From childhood to adolescence: Long-term trends in severe obesity in German youth (2002–2023)

description: Abstract
Introduction
Research on severe obesity (SO) is scarce and often contradictory. As higher weight status persists into adulthood, we aimed to analyze long-term trends in the prevalence of SO in children and adolescents in Germany using a large real-world data set. Furthermore, we analyzed subgroup differences and assessed how the COVID-19 pandemic affected weight status.


Methods
We analyzed data from the CrescNet auxological network including 1,495,401 clinical visits by 4-16-year-old children (2002-2023). Weight trends were examined with a focus on SO using logistic regression, stratified by sex and age. Effects are reported as odds ratio per 5 years (OR5) pre-pandemic and as OR for consecutive years during the pandemic. Quantile regression assessed trends of the 50th, 90th, 97th, and 99th percentiles of excess weight.

Results
Pre-pandemic, SO remained stable or declined in children under 12 until 2010: OR5: 0.8-1, p&lt;0.001) but rose significantly afterward (OR5: 1.1-1.2, p&lt;0.001). Children between 12-16 years of age showed a continuous increase, especially boys (boys12-16: OR5: 1.3, girls12-16: OR5: 1.1, p&lt;0.001). During the pandemic, SO peaked in 2021 across all groups (OR21vs19: 1.3-1.7, p&lt;0.001). By 2023, younger children returned to pre-pandemic levels, while older children, particularly 8-16-year-old girls, remained at higher weights (OR23vs19: 1.2-1.5, p&lt;0.001-0.002). Weight gain was most prominent in SO groups but could also be seen in pre-pandemic and pandemic overweight and obesity subgroups, generally decreasing toward the end of the pandemic. 

Conclusion
SO has increased over the last two decades, with the COVID-19 pandemic accelerating this trend, particularly in adolescents. While younger children recovered by 2023, excess weight in older children, especially girls, continues to escalate.
DOI: 10.6084/m9.figshare.640020.v1
title: Accuracies, run times, and statistics for genetic algorithms with various mutation rates maximizing a 3D function.

description: In the 3dfloatnomut, 3dfloatconstmut, and 3dfloatsigmoid tabs, the maximum value found by that genetic algorithm is displayed along with the time the algorithm took to converge to that maximum (in generations). In the stats tabs, t-tests are run to compare the accuracies and convergence generations among the different mutation rate genetic algorithms.
DOI: 10.17632/nhyh3pb748
title: Fluidized bed membrane reactor - vertical membranes configurations

description: The Two-Fluid Model was used to study hydrogen production in a fluidized bed membrane reactor using various configurations of vertically immersed membranes (fully selective extraction of hydrogen). The datasets contain the time-averaged properties for phase velocity (U.air, U.particles), hydrogen mole fraction (X.air) and particle phase fractions (alpha.particles). The files can be visualized using Paraview (see www.paraview.org). A state file is supplied as well that allows easy visualization of the hydrogen molar fraction profiles. Short manual for using the state file (Paraview 5.6.0): - Download all files - Paraview &gt; File &gt; Load state - Select state3.pvsm - In "Load State Data File Options" select "Choose file names" - Choose the .vtk file (e.g. VM3close.vtk) - Results should appear and can be interactively explored. (further information regarding the linked journal publication will be updated after acceptance of the manuscript)
DOI: 10.6084/m9.figshare.16563444.v1
title: FINAL for Publication

description: FINAL (for publication) Supplemental Figures and Materials and Methods
DOI: 10.6084/m9.figshare.22336492.v1
title: An eikonal equation-based earthquake location method with joint inversion of the first P and sPg traveltimes

description: Precise and accurate hypocenters are important for the seismotectonic study, the assessment of seismic hazard and seismic tomography. The first P arrival times are widely used in earthquake location. However, the earthquake location methods using the first P arrival times lack of constraint on the focal depths due to the traveltimes of the first P‐phase are less sensitive to focal depth. To improve the accuracy of focal depth, regional depth-phase methods has been proposed. The regional depth-phase methods greatly improve the precision of focal depth because the regional depth-phases are sensitive to the focal depth. Owing to the theoretical arrival time differences are calculated in one-dimensional layered model, the focal depths determined by the depth-phase location methods deviate from the real location when the existence of large differences between the underground structures and the layered model. In order to improve the accuracy of focal depths and reduce the influence of model errors, we use the fast marching method to solve eikonal equation and obtain the first P and sPg traveltimes in a heterogeneous model. Then, conduct earthquake locations by joint inversion of the first P and sPg traveltimes. To validate the proposed method, we conduct synthetic and practical location studies of the 2022 file:///C:/Users/ADMINI~1/AppData/Local/Temp/msohtmlclip1/01/clip_image002.gif6.8 Luding earthquake. Results show that the proposed method can improve the accuracy of earthquake location.
DOI: 10.6084/m9.figshare.23910282.v2
title: Genomic sequence and genome annotation of <i>Quercus variabilis</i>

description: Genome assembly of Quercus variabilis. Here we shared the annotation files including CDS sequences (QV.cds) and peptide sequences (QV.pep.fa) in fasta format, and also gff annotation file.
DOI: 10.6084/m9.figshare.5603203.v5
title: GWAS of Alzheimer's disease progression score

description: Summary statistics for the three GWAS of 1517 Caucasian ADNI subjects described in Scelsi et al. - "Genetic study of multimodal imaging Alzheimer’s disease progression score implicates novel loci", manuscript under review at BRAIN (submission ID: BRAIN-2017-01752).1) FILE: ADNI_hippo_GWAS_EduCovar_NewUnrelated.assoc.linear; DESCRIPTION: GWAS (chromosomes 1-22) for bilateral hippocampal volume, correcting for age, sex, years of education, PC1-2, number of APOE4 alleles2) FILE: ADNI_amyloid_GWAS_EduCovar_NewUnrelated.assoc.linear; DESCRIPTION: GWAS (chromosomes 1-22) for cortical PET SUVR, correcting for age, sex, years of education, PC1-2, number of APOE4 alleles3) FILE: ADNI_DPS_GWAS_AmyHippoEduCovar_NewUnrelated.assoc.linear; DESCRIPTION: GWAS (chromosomes 1-22) for Disease Progression Score (DPS), correcting for age, sex, years of education, PC1-2, number of APOE4 alleles, baseline hippocampal volume, baseline PET SUVR4) FILE: ADNI_FullSample_chrX_newPC.hippo.EDUcovar.xstrat.linear; DESCRIPTION: Sex-stratified (Stouffer's method) association test of chromosome X for bilateral hippocampal volume, correcting for age, years of education, PC1-2, number of APOE4 alleles5) FILE: ADNI_FullSample_chrX_newPC.amyloid.EDUcovar.xstrat.linear; DESCRIPTION: Sex-stratified (Stouffer's method) association test of chromosome X for cortical PET SUVR, correcting for age, years of education, PC1-2, number of APOE4 alleles6) FILE: ADNI_FullSample_chrX_newPC.DPSupdate.amyhippoEDUcovar.xstrat.linear; DESCRIPTION: Sex-stratified (Stouffer's method) association test of chromosome X for DPS, correcting for age, years of education, PC1-2, number of APOE4 alleles, baseline hippocampal volume, baseline PET SUVR