cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.30818111
title: Metabolic dysfunction-associated fatty liver disease and risk of hypertension in young adults: A cross-sectional study mediated by inflammatory markers

description: This study aimed to investigate the prevalence of hypertension among young adults with MAFLD, assess the association between the presence and severity of MAFLD and hypertension, and explore potential mediating mechanisms linking MAFLD and hypertension in this population. A total of 5,327 individuals aged 18−45 years from the National Health and Nutrition Examination Survey (2017−2023) were included. Multivariable logistic regression analysis was performed to evaluate the independent associations of MAFLD and its severity with hypertension and isolated diastolic hypertension. Mediation analysis assessed the mediating effects of inflammatory markers, including white blood cell (WBC) count, neutrophil count, and systemic immune-inflammation index (SII). The prevalence of MAFLD in the study population was 44.05%. Hypertension prevalence in the MAFLD group was significantly higher than in the non-MAFLD group (37.68% vs. 15.19%, <i>P</i> &lt; 0.001). After adjusting for sex, age, race, alcohol consumption, and comorbidities such as diabetes and renal insufficiency, individuals with MAFLD and moderate-to-severe fibrosis exhibited a significantly higher risk of hypertension compared to non-MAFLD individuals (OR = 3.414, 95% CI: 2.522−4.622), <i>P</i> &lt; 0.001). Mediation analysis demonstrated that WBC, neutrophils, and SII mediated 7.62% (95% CI: 2.75–15.00), 6.71% (95% CI: 2.48–12.65), and 5.90% (95% CI: 2.40–10.88) of the association between MAFLD and hypertension, respectively. MAFLD, particularly in the presence of advanced liver fibrosis, is strongly and independently associated with hypertension in young adults. Systemic inflammation acts as a key mediator in this relationship, highlighting its potential as a therapeutic target for precision antihypertensive strategies in this population.
DOI: 10.3535/4e8-q4q-vzw
title: Conistra (Dasycampa) rubiginea ([Denis & Schiffermüller], 1775)

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.6084/m9.figshare.30818111.v1
title: Metabolic dysfunction-associated fatty liver disease and risk of hypertension in young adults: A cross-sectional study mediated by inflammatory markers

description: This study aimed to investigate the prevalence of hypertension among young adults with MAFLD, assess the association between the presence and severity of MAFLD and hypertension, and explore potential mediating mechanisms linking MAFLD and hypertension in this population. A total of 5,327 individuals aged 18−45 years from the National Health and Nutrition Examination Survey (2017−2023) were included. Multivariable logistic regression analysis was performed to evaluate the independent associations of MAFLD and its severity with hypertension and isolated diastolic hypertension. Mediation analysis assessed the mediating effects of inflammatory markers, including white blood cell (WBC) count, neutrophil count, and systemic immune-inflammation index (SII). The prevalence of MAFLD in the study population was 44.05%. Hypertension prevalence in the MAFLD group was significantly higher than in the non-MAFLD group (37.68% vs. 15.19%, <i>P</i> &lt; 0.001). After adjusting for sex, age, race, alcohol consumption, and comorbidities such as diabetes and renal insufficiency, individuals with MAFLD and moderate-to-severe fibrosis exhibited a significantly higher risk of hypertension compared to non-MAFLD individuals (OR = 3.414, 95% CI: 2.522−4.622), <i>P</i> &lt; 0.001). Mediation analysis demonstrated that WBC, neutrophils, and SII mediated 7.62% (95% CI: 2.75–15.00), 6.71% (95% CI: 2.48–12.65), and 5.90% (95% CI: 2.40–10.88) of the association between MAFLD and hypertension, respectively. MAFLD, particularly in the presence of advanced liver fibrosis, is strongly and independently associated with hypertension in young adults. Systemic inflammation acts as a key mediator in this relationship, highlighting its potential as a therapeutic target for precision antihypertensive strategies in this population.
DOI: 10.3535/57r-x7z-zy5
title: Parascotia fuliginaria (Linnaeus, 1761)

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/8fl-zgr-98r
title: Xestia (Megasema) c-nigrum (Linnaeus, 1758)

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/kel-ba5-7ja
title: Apamea (Apamea) remissa (Hübner)

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.6084/m9.figshare.30179655
title: miPEP31 inhibits the vascular smooth muscle cell proliferation via cooperation with transcription factor Trps1

description: Our previous study has found that miPEP31, which is encoded by pri-miRNA-31, inhibits the transcription of pri-miRNA-31 and alleviates angiotensin (Ang) II-induced hypertension. miR-31 is involved in proliferation of primary vascular smooth muscle cells (VSMCs), the key functional cells involved in hypertensive vascular remodeling. However, the role and mechanism of miPEP31 in the proliferation of VSMCs remain unclear. The aim of this study is to investigate whether miPEP31 plays an important role in VSMC proliferation and contributes to vascular remodeling. We found that the administration of synthetic miPEP31 mitigated but miPEP31 deficiency aggravated the Ang II-induced aortic thickness of intima plus media and fibrotic area. miPEP31 is endogenously expressed and penetrates into nuclei in VSMCs. miPEP31 inhibits PDGF-BB-induced VSMC proliferation in a dose-dependent manner and decreases the Ang Ⅱ-induced aortic α-SMA staining area. Mechanistically, we demonstrated that miPEP31 acts as a transcriptional repressor and inhibits miR-31 expression by cooperating with Trps1, a GATA family zinc finger transcription factor. In summary, our study suggests that miPEP31 protects against vascular remodeling in Ang II-infused mice via cooperation with transcription factor Trps1 to inhibit miR-31 expression and, subsequently, VSMC proliferation. This finding highlights the therapeutic effect and role of miPEP31 on hypertensive target organs and functional cells.
DOI: 10.6084/m9.figshare.30179655.v1
title: miPEP31 inhibits the vascular smooth muscle cell proliferation via cooperation with transcription factor Trps1

description: Our previous study has found that miPEP31, which is encoded by pri-miRNA-31, inhibits the transcription of pri-miRNA-31 and alleviates angiotensin (Ang) II-induced hypertension. miR-31 is involved in proliferation of primary vascular smooth muscle cells (VSMCs), the key functional cells involved in hypertensive vascular remodeling. However, the role and mechanism of miPEP31 in the proliferation of VSMCs remain unclear. The aim of this study is to investigate whether miPEP31 plays an important role in VSMC proliferation and contributes to vascular remodeling. We found that the administration of synthetic miPEP31 mitigated but miPEP31 deficiency aggravated the Ang II-induced aortic thickness of intima plus media and fibrotic area. miPEP31 is endogenously expressed and penetrates into nuclei in VSMCs. miPEP31 inhibits PDGF-BB-induced VSMC proliferation in a dose-dependent manner and decreases the Ang Ⅱ-induced aortic α-SMA staining area. Mechanistically, we demonstrated that miPEP31 acts as a transcriptional repressor and inhibits miR-31 expression by cooperating with Trps1, a GATA family zinc finger transcription factor. In summary, our study suggests that miPEP31 protects against vascular remodeling in Ang II-infused mice via cooperation with transcription factor Trps1 to inhibit miR-31 expression and, subsequently, VSMC proliferation. This finding highlights the therapeutic effect and role of miPEP31 on hypertensive target organs and functional cells.
DOI: 10.6084/m9.figshare.30281124
title: The causal relationship between aspartate aminotransferase and hypertension: A bidirectional Mendelian randomization study

description: Hypertension is a major contributor to the global burden of disease and increased mortality in the general population. Currently, the etiology and pathogenesis of hypertension are not fully understood. Emerging evidence suggests an association between aspartate aminotransferase (AST) and hypertension, but whether this relationship is causal remains unclear. A two-sample MR analysis was conducted using GWAS summary data. Five MR methods – MR-Egger, weighted median, inverse variance weighted (IVW), simple mode, and weighted mode – were applied, with IVW as the primary approach. Sensitivity analyses, including heterogeneity and pleiotropy assessments, as well as leave-one-out (LOO) analysis, were performed. Functional annotation of non-coding SNPs was conducted using the 3DSNP database, while GeneMania and enrichment analysis explored gene interactions and biological pathways. Forward MR analysis using the IVW method indicated a significant causal effect of AST on hypertension (<i>β</i> = 0.0003, Standard Error (SE) = 6.93E−05, <i>P</i> = 0.0002). However, reverse MR analysis found no significant causal relationship between hypertension and AST (<i>β</i> = 15.7148, SE = 12.7551 <i>P</i> = 0.2179). The results of MR-Egger regression, Weighted Median, and Weighted Mode methods were consistent with those of the IVW method. These findings were robust across several reliability analyses. Finally, network and functional enrichment analyses showed that, under the influence of IVs, the SNP-hosted genes and AST promote disease progression through involvement in aspartic acid family metabolism and hexose biosynthesis. The present study reports the potential role of AST in the development of hypertension. The link between AST and hypertension may be due to regulation of substance and energy metabolism. These findings offer new insights into the pathophysiology of hypertension and suggest that AST could serve as a potential biomarker or therapeutic target for hypertension management.
DOI: 10.6084/m9.figshare.30281124.v1
title: The causal relationship between aspartate aminotransferase and hypertension: A bidirectional Mendelian randomization study

description: Hypertension is a major contributor to the global burden of disease and increased mortality in the general population. Currently, the etiology and pathogenesis of hypertension are not fully understood. Emerging evidence suggests an association between aspartate aminotransferase (AST) and hypertension, but whether this relationship is causal remains unclear. A two-sample MR analysis was conducted using GWAS summary data. Five MR methods – MR-Egger, weighted median, inverse variance weighted (IVW), simple mode, and weighted mode – were applied, with IVW as the primary approach. Sensitivity analyses, including heterogeneity and pleiotropy assessments, as well as leave-one-out (LOO) analysis, were performed. Functional annotation of non-coding SNPs was conducted using the 3DSNP database, while GeneMania and enrichment analysis explored gene interactions and biological pathways. Forward MR analysis using the IVW method indicated a significant causal effect of AST on hypertension (<i>β</i> = 0.0003, Standard Error (SE) = 6.93E−05, <i>P</i> = 0.0002). However, reverse MR analysis found no significant causal relationship between hypertension and AST (<i>β</i> = 15.7148, SE = 12.7551 <i>P</i> = 0.2179). The results of MR-Egger regression, Weighted Median, and Weighted Mode methods were consistent with those of the IVW method. These findings were robust across several reliability analyses. Finally, network and functional enrichment analyses showed that, under the influence of IVs, the SNP-hosted genes and AST promote disease progression through involvement in aspartic acid family metabolism and hexose biosynthesis. The present study reports the potential role of AST in the development of hypertension. The link between AST and hypertension may be due to regulation of substance and energy metabolism. These findings offer new insights into the pathophysiology of hypertension and suggest that AST could serve as a potential biomarker or therapeutic target for hypertension management.
DOI: 10.3535/g4p-673-1m0
title: Orthosia (Semiophora) gothica Linnaeus, 1758

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/r9j-r91-qpz
title: Litoligia literosa (Haworth, 1809)

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.6084/m9.figshare.29907993
title: Association between uric acid and aortic aneurysms: A two-sample Mendelian randomization study

description: Based on Mendelian randomization (MR) methods, this study aims to explore causal associations of uric acid (UA) levels with aortic aneurysms (AAs). In this MR study, data on UA levels and gout were extracted from genome-wide association study (GWAS) meta-analysis conducted by UK Biobank (UKB) for European population and the Biobank Japan Project (BBJ) for Asian population. Summary statistics of AAs were obtained from different databases. Inverse variance weighted (IVW), weighted-mode, weighted median, MR-Egger, and MR-PRESSO methods were used to examine the potential causal association of UA with AAs. The IVW estimates indicated that elevated UA level was associated with higher AAA risk among the European population (OR = 1.315, 95%CI: 1.024–1.689). In the Asian population, the UA level was positively linked to the odds of AA (OR = 1.393, 95%CI: 1.061–1.829). In addition, sensitivity analyses through MR leave-one-out and single SNP effect methods showed that these results were relatively robust. UA may be a potential risk factor for AAs, indicating that clinicians should focus on serum UA levels among populations with high-risk of AAs. Studies to reveal the true relationship between them and clarify the underlying mechanism are still needed in the future.
DOI: 10.6084/m9.figshare.29907993.v1
title: Association between uric acid and aortic aneurysms: A two-sample Mendelian randomization study

description: Based on Mendelian randomization (MR) methods, this study aims to explore causal associations of uric acid (UA) levels with aortic aneurysms (AAs). In this MR study, data on UA levels and gout were extracted from genome-wide association study (GWAS) meta-analysis conducted by UK Biobank (UKB) for European population and the Biobank Japan Project (BBJ) for Asian population. Summary statistics of AAs were obtained from different databases. Inverse variance weighted (IVW), weighted-mode, weighted median, MR-Egger, and MR-PRESSO methods were used to examine the potential causal association of UA with AAs. The IVW estimates indicated that elevated UA level was associated with higher AAA risk among the European population (OR = 1.315, 95%CI: 1.024–1.689). In the Asian population, the UA level was positively linked to the odds of AA (OR = 1.393, 95%CI: 1.061–1.829). In addition, sensitivity analyses through MR leave-one-out and single SNP effect methods showed that these results were relatively robust. UA may be a potential risk factor for AAs, indicating that clinicians should focus on serum UA levels among populations with high-risk of AAs. Studies to reveal the true relationship between them and clarify the underlying mechanism are still needed in the future.
DOI: 10.3535/8s2-eqz-xjy
title: Brachionycha nubeculosa Esper, 1785

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/rt1-wl5-l4q
title: Amphipoea Billberg, 1820

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/7zc-q11-saj
title: Oligia Hübner, 1821

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/5xe-amz-nbe
title: Xanthia (Cirrhia) Hübner, 1816

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/9hz-aew-88l
title: Leucoma salicis (Linnaeus, 1758)

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.15468/dl.csca5s
title: Occurrence Download

description: A dataset containing 3655 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Osyris lanceolata",
 "HasCoordinate is true"
 ]
}

 The dataset includes 3655 records from 38 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0058084-251120083545085/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.3535/nfl-4l1-pha
title: Diaphora mendica (Clerck, 1759)

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/y19-tpa-18l
title: Xestia (Pachnobia) tecta Hübner

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/d35-pjk-ar1
title: Protolampra sobrina Duponchel, 1843

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/ha9-cya-fze
title: Autographa gamma (Linnaeus, 1758)

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/tc3-ykh-98e
title: Diarsia dahlii Hübner, 1813

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/kvs-sdq-kfc
title: Protolampra sobrina Duponchel, 1843

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/jnc-wda-rw5
title: Episcythrastis Meyrick, 1937

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/9wr-mzm-vhq
title: Sympistis Hübner, 1823

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/pqz-vvr-r0e
title: Autographa pulchrina (Haworth, 1809)

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/t1p-5r3-w2l
title: Cerastis rubricosa [Denis & Schiffermüller], 1775

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/5bc-zhw-96t
title: Hyppa rectilinea (Esper, 1788)

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/f93-m0r-q5j
title: Oligia Hübner, 1821

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/c70-khx-hsk
title: Indalia pygmaeola (Doubleday, 1847)

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/kl7-2sk-bwb
title: Orthosia (Semiophora) gothica Linnaeus, 1758

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.15468/dl.347pky
title: Occurrence Download

description: A dataset containing 10 species occurrences available in GBIF matching the query:
{
 "and" : [
 "BasisOfRecord is Specimen",
 "TaxonKey is Besleria leucostoma"
 ]
}

 The dataset includes 10 records from 6 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0058085-251120083545085/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.3535/drq-f4r-k1e
title: Diarsia dahlii Hübner, 1813

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/lrx-4kn-gzc
title: Katha depressa (Esper, 1786)

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/0z4-hy2-9t5
title: Autographa gamma (Linnaeus, 1758)

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/ads-af1-sn1
title: Agonopterix ocellana Fabricius, 1775

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/kkc-n02-x8s
title: Enargia paleacea (Esper, 1788)

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/jqj-8za-8wr
title: Conistra (Dasycampa) rubiginea ([Denis & Schiffermüller], 1775)

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/4y5-t6d-dyb
title: Scoparia ambigualis Treitschke, 1829

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/ab7-5xa-lk7
title: Indalia pygmaeola (Doubleday, 1847)

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/jej-vlr-srt
title: Katha depressa (Esper, 1786)

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.25824/redu/hlll9d
title: Dados sobre o conhecimento interpretativo e especializado de professores de matemática no âmbito das transformações geométricas isométricas e simetria

description: Apresentam-se como dados da pesquisa de doutorado as transcrições literais das produções escritas dos participantes (professores de matemática dos anos finais e ensino médio) de um contexto de formação contínua (40 horas, organizados em nove encontros) focando no Conhecimento Interpretativo e Especializado no âmbito das transformações geométricas isométricas e simetria.
DOI: 10.3535/lbp-ref-ync
title: Brachionycha nubeculosa Esper, 1785

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/sqq-vjj-m9d
title: Sympistis Hübner, 1823

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/xt8-fzf-h63
title: Falcaria lacertinaria (Linnaeus, 1758)

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/dv0-1wj-z1s
title: Ochropacha duplaris (Linnaeus, 1761)

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/v06-98f-1wk
title: Ammoconia caecimacula [Denis & Schiffermüller], 1775

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/5fl-e7t-5yc
title: Diarsia dahlii Hübner, 1813

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/e3j-q3f-3tt
title: Brachionycha nubeculosa Esper, 1785

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/wrl-lpv-xeh
title: Animalia

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/v6j-762-n4l
title: Catoptria maculalis Zetterstedt, 1840

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/94s-4qb-v11
title: Eudonia truncicolella (Stainton, 1849)

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/q9q-xhe-lt1
title: Autographa gamma (Linnaeus, 1758)

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/1zt-hy2-qqd
title: Oligia Hübner, 1821

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/c4s-2fq-14a
title: Plusia festucae (Linnaeus, 1758)

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/hd5-vj8-fk6
title: Cerastis rubricosa [Denis & Schiffermüller], 1775

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/ryd-kwb-qp6
title: Episcythrastis Meyrick, 1937

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.