cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.5896243
title: The cost of achieving South Africa’s ‘fair share’ of global climate change mitigation

description: Global climate change mitigation action is hampered by systematic under-assessment of national ‘fair shares’, largely on the basis of perceived national interests. This paper aims to inform discussions centred on South Africa’s nationally determined contribution (NDC) by estimating (1) emissions reduction pathways for the country using the Climate Equity Reference Calculator (CERC) assuming a maximum 2°C aggregate warming target and (2) the likely economy-wide net mitigation costs or savings associated with reaching these pathways if known lower-cost mitigation measures, identified through the national mitigation potential analysis, are prioritised. The cumulative net savings associated with achieving the CERC ‘fair share’ emissions pathway, assuming the moderate use of low carbon power generation measures, would reach $5.3 billion by 2030. Net savings could be substantially greater reaching $46.8 billion by 2030 assuming power generation focuses on moving towards full decarbonisation. An unconditional commitment to the mitigation action implied by the ‘fair share’ emissions pathway therefore seems reasonable and prudent purely from the point of view of net country-wide savings. Only if power generation moves towards full decarbonisation would there be a reasonable chance of achieving the more ambitious CERC domestic emissions pathway. However, the significant additional cost associated with achieving the domestic emissions pathway should be conditional on international assistance. <b>Key policy insights</b>South Africa can only achieve its ‘fair share’ of the global mitigation effort if greater use is made of renewable energy options, and can realise significant net savings if it does so.Further emissions reductions would incur costs and require significant upscaling of the share of renewable energy and full implementation of all non-power generation mitigation measures available.Committing to this further mitigation action contingent on international finance would both strengthen the nation’s position in climate negotiations and support the provision of finance for those vulnerable developing nations that bear little or no responsibility for climate change. South Africa can only achieve its ‘fair share’ of the global mitigation effort if greater use is made of renewable energy options, and can realise significant net savings if it does so. Further emissions reductions would incur costs and require significant upscaling of the share of renewable energy and full implementation of all non-power generation mitigation measures available. Committing to this further mitigation action contingent on international finance would both strengthen the nation’s position in climate negotiations and support the provision of finance for those vulnerable developing nations that bear little or no responsibility for climate change.
DOI: 10.6084/m9.figshare.5896243.v1
title: The cost of achieving South Africa’s ‘fair share’ of global climate change mitigation

description: Global climate change mitigation action is hampered by systematic under-assessment of national ‘fair shares’, largely on the basis of perceived national interests. This paper aims to inform discussions centred on South Africa’s nationally determined contribution (NDC) by estimating (1) emissions reduction pathways for the country using the Climate Equity Reference Calculator (CERC) assuming a maximum 2°C aggregate warming target and (2) the likely economy-wide net mitigation costs or savings associated with reaching these pathways if known lower-cost mitigation measures, identified through the national mitigation potential analysis, are prioritised. The cumulative net savings associated with achieving the CERC ‘fair share’ emissions pathway, assuming the moderate use of low carbon power generation measures, would reach $5.3 billion by 2030. Net savings could be substantially greater reaching $46.8 billion by 2030 assuming power generation focuses on moving towards full decarbonisation. An unconditional commitment to the mitigation action implied by the ‘fair share’ emissions pathway therefore seems reasonable and prudent purely from the point of view of net country-wide savings. Only if power generation moves towards full decarbonisation would there be a reasonable chance of achieving the more ambitious CERC domestic emissions pathway. However, the significant additional cost associated with achieving the domestic emissions pathway should be conditional on international assistance. <b>Key policy insights</b>South Africa can only achieve its ‘fair share’ of the global mitigation effort if greater use is made of renewable energy options, and can realise significant net savings if it does so.Further emissions reductions would incur costs and require significant upscaling of the share of renewable energy and full implementation of all non-power generation mitigation measures available.Committing to this further mitigation action contingent on international finance would both strengthen the nation’s position in climate negotiations and support the provision of finance for those vulnerable developing nations that bear little or no responsibility for climate change. South Africa can only achieve its ‘fair share’ of the global mitigation effort if greater use is made of renewable energy options, and can realise significant net savings if it does so. Further emissions reductions would incur costs and require significant upscaling of the share of renewable energy and full implementation of all non-power generation mitigation measures available. Committing to this further mitigation action contingent on international finance would both strengthen the nation’s position in climate negotiations and support the provision of finance for those vulnerable developing nations that bear little or no responsibility for climate change.
DOI: 10.6084/m9.figshare.5896063
title: Assessment of genetic diversity, population structure, and gene flow of tigers (Panthera tigris tigris) across Nepal's Terai Arc Landscape

description: Nepal Tiger Genome Project (NTGP), a two year (June 2011- 2013) research project to build genetic database of wild Bengal tigers of Nepal. NTGP is a collaborative effort of Center for Molecular Dynamics Nepal, Nepal Government’s Ministry of Forest and Soil Conservation, Department of National Parks and Wildlife Conservation, University of Idaho and Virginia Tech University. The project introduced latest genetic technology in Nepal for wildlife conservation and has built Nepal’s first geo-spatial genetic database of Bengal tigers from throughout the Terai Arc landscape. NTGP was made possible through generous funding support of the American people through USAID/Nepal under Fixed Obligation Grant (FOG) no. AID-367-G-11-00001. Conservation of the Bengal tigers in Nepal is a top priority due to its dwindling number of species worldwide. It is important to have a comprehensive understanding of tiger conservation from a landscape perspective. In order to develop effective policies and strategies for the conservation of Bengal tigers, effective census tools need to be developed and deployed. The conventional tools for conservation are often inadequate and ineffective to address the problem. NTGP introduced the latest in non-invasive genetic technology to address many challenges of tiger conservation in Nepal. Due to its high specificity and sensitivity, information obtained through a genetic study is more detailed than conventionally gathered data. It can also be applied to understand landscape genetics of the species which has great utility for developing overall conservation policies and strategies on a landscape scale. In addition to introducing new genetic technology in Nepal, NTGP also enhanced existing laboratory capacity and fostered an environment of conservation research collaboration in a global scale. A comprehensive Bengal tiger genetic database has been created with detailed field, laboratory and genetic information on confirmed tiger samples. This elaborate searchable database is designed to be highly secure and accessible only to the government with CMDN being the caretaker of the information; this database has a greater utility for wildlife research and forensic purposes. NTGP has been able to leave a long lasting impact in the field of conservation genetics in Nepal. The project itself has trained 75 local experts, created 43 jobs, brought in experts from 4 countries, and helped in five other similar researches in Nepal.
DOI: 10.6084/m9.figshare.5896009
title: Jasmonic acid facilitates flower opening and floral organ development through the upregulated expression of SlMYB21 transcription factor in tomato

description: Plants coordinate the timing of flower opening with pollen and gynoecium maturation to achieve successful pollination. However, little is known about how the coordination is executed. We found that flower bud development was paused immediately before flower opening in a jasmonic acid (JA)-insensitive tomato mutant, <i>jai1</i>-<i>1</i>. Phytohormone measurement and RNA analysis in flower buds revealed that newly synthesised JA peaked at two days before flower opening and the expression of a transcription factor gene <i>SlMYB21</i> delayed in <i>jai1</i>-<i>1</i>. Buds of transgenic tomato plants expressing an artificial repressor, <i>AtMYB24</i>-<i>SRDX</i>, which was expected to impede the function of <i>SlMYB21</i>, aborted flower opening and resembled those of <i>jai1</i>-<i>1</i>. Furthermore, the <i>AtMYB24</i>-<i>SRDX</i> plants produced abnormal pollen grains deficient in germination and pistils that did not support pollen tube elongation. We concluded that JA facilitates the expression of <i>SlMYB21</i>, which coordinates flower opening, pollen maturation, and gynoecium function in tomato. Jasmonic acid stimulates <i>SlMYB21</i> expression, which is required for coordinated flower opening and fertility in male and female organs in tomato.
DOI: 10.6084/m9.figshare.5896009.v1
title: Jasmonic acid facilitates flower opening and floral organ development through the upregulated expression of SlMYB21 transcription factor in tomato

description: Plants coordinate the timing of flower opening with pollen and gynoecium maturation to achieve successful pollination. However, little is known about how the coordination is executed. We found that flower bud development was paused immediately before flower opening in a jasmonic acid (JA)-insensitive tomato mutant, <i>jai1</i>-<i>1</i>. Phytohormone measurement and RNA analysis in flower buds revealed that newly synthesised JA peaked at two days before flower opening and the expression of a transcription factor gene <i>SlMYB21</i> delayed in <i>jai1</i>-<i>1</i>. Buds of transgenic tomato plants expressing an artificial repressor, <i>AtMYB24</i>-<i>SRDX</i>, which was expected to impede the function of <i>SlMYB21</i>, aborted flower opening and resembled those of <i>jai1</i>-<i>1</i>. Furthermore, the <i>AtMYB24</i>-<i>SRDX</i> plants produced abnormal pollen grains deficient in germination and pistils that did not support pollen tube elongation. We concluded that JA facilitates the expression of <i>SlMYB21</i>, which coordinates flower opening, pollen maturation, and gynoecium function in tomato. Jasmonic acid stimulates <i>SlMYB21</i> expression, which is required for coordinated flower opening and fertility in male and female organs in tomato.
DOI: 10.6084/m9.figshare.5895991
title: mars_simulations_18feb15

description: Output from numerical simulations created from the Mercury integration package (Chambers 2013).
DOI: 10.6084/m9.figshare.5895991.v1
title: mars_simulations_18feb15

description: Output from numerical simulations created from the Mercury integration package (Chambers 2013).
DOI: 10.6084/m9.figshare.5895955
title: <i>Preussia</i> sp. BSL-10 producing nitric oxide, gibberellins, and indole acetic acid and improving rice plant growth

description: <i>Preussia</i> sp. have been least known to improve plant growth and produce phytohormones. The current study investigated the production of nitric oxide (NO), indole-3-acetic acid (IAA), and gibberellins (GA<sub>4</sub>, GA<sub>7</sub>, GA<sub>15</sub>, and GA<sub>53</sub>) by a novel endophytic-fungal strain <i>Preussia</i> sp<i>.</i> BSL-10 using advanced chromatographic and spectroscopic techniques. Production of these phytohormones were validated by RT–PCR analysis, which indicated the expression of genes encoding <i>tryptophan synthase</i> (<i>TRP</i>), <i>indole-3-acetamide hydrolase (IAAH), tryptophan-2-monooxygenase (IAAM), aldehyde dehydrogenase (ALD), GA<sub>4</sub> desaturase (DES), geranylgeranyl-diphosphate synthase (GGS2), ent-desaturase oxidase (P450-4), GA<sub>14</sub> synthase (P450-1) and nitrite reductase (NIRK/NIRS), cytochrome P450 (P450nor), nitrate reductase (NR), NOS-like (NOL),</i> and <i>nitric oxide reductase (QNOR/CNOR).</i> In plant growth-promoting effects, the inoculation of <i>Preussia</i> sp. BSL-10 significantly increased the growth of dwarf mutant <i>Waito-C</i> and wild-type rice cultivars. In conclusion, utilizing new endophytic with the ability to produce NO, IAA, and gibberellins can be used to promote growth and yield of marginalized crops.
DOI: 10.6084/m9.figshare.5895904
title: Adaptive Strategies to Displacement and Environmental Change Among the Kaiabi Indigenous People of the Brazilian Amazon

description: Environmental change, geographical displacement, and disputes over land and resources have increased around the world. This article focuses on strategies developed by the Kaiabi indigenous people to cope and adapt to environmental change after development-forced displacement and resettlement in the Brazilian Amazon. A mixed methods approach was adopted, combining ethnographic and quantitative methods. Semistructured interviews were performed among 214 individuals in a study on the dynamics of indigenous knowledge (IK) and natural resource management across three Kaiabi lands. We identified seven main coping and adaptive strategies developed by the displaced group: leadership and reciprocity networks, mobility, maintenance and innovation of native language, knowledge articulation, substitution of strategic resources, transmission across genders, and revitalizing diversity. These strategies have helped to enhance social–ecological resilience at different scales. Policies for resettlement and adaptation to environmental change must be developed with indigenous communities based on local knowledge and institutions.
DOI: 10.6084/m9.figshare.5895904.v1
title: Adaptive Strategies to Displacement and Environmental Change Among the Kaiabi Indigenous People of the Brazilian Amazon

description: Environmental change, geographical displacement, and disputes over land and resources have increased around the world. This article focuses on strategies developed by the Kaiabi indigenous people to cope and adapt to environmental change after development-forced displacement and resettlement in the Brazilian Amazon. A mixed methods approach was adopted, combining ethnographic and quantitative methods. Semistructured interviews were performed among 214 individuals in a study on the dynamics of indigenous knowledge (IK) and natural resource management across three Kaiabi lands. We identified seven main coping and adaptive strategies developed by the displaced group: leadership and reciprocity networks, mobility, maintenance and innovation of native language, knowledge articulation, substitution of strategic resources, transmission across genders, and revitalizing diversity. These strategies have helped to enhance social–ecological resilience at different scales. Policies for resettlement and adaptation to environmental change must be developed with indigenous communities based on local knowledge and institutions.
DOI: 10.6084/m9.figshare.5895898
title: The first Loranthaceae fossils from Africa

description: An ongoing re-investigation of the early Miocene Saldanha Bay (South Africa) palynoflora, using combined light and scanning electron microscopy (single grain method), is revealing several pollen types new to the African fossil record. One of the elements identified is Loranthaceae pollen. These grains represent the first and only fossil record of Loranthaceae in Africa. The fossil pollen grains resemble those produced by the core Lorantheae and are comparable to recent Asian as well as some African taxa/lineages. Molecular and fossil signals indicate that Loranthaceae dispersed into Africa via Asia sometime during the Eocene. The present host range of African Loranthaceae and the composition of the palynoflora suggest that the fossil had a range of potential host taxa to parasitise during the early Miocene in the Saldanha Bay region.
DOI: 10.6084/m9.figshare.5895898.v1
title: The first Loranthaceae fossils from Africa

description: An ongoing re-investigation of the early Miocene Saldanha Bay (South Africa) palynoflora, using combined light and scanning electron microscopy (single grain method), is revealing several pollen types new to the African fossil record. One of the elements identified is Loranthaceae pollen. These grains represent the first and only fossil record of Loranthaceae in Africa. The fossil pollen grains resemble those produced by the core Lorantheae and are comparable to recent Asian as well as some African taxa/lineages. Molecular and fossil signals indicate that Loranthaceae dispersed into Africa via Asia sometime during the Eocene. The present host range of African Loranthaceae and the composition of the palynoflora suggest that the fossil had a range of potential host taxa to parasitise during the early Miocene in the Saldanha Bay region.
DOI: 10.6084/m9.figshare.5895847
title: The clinician impact and financial cost to the NHS of litigation over pregabalin - a Jupyter notebook

description: A notebook containing the calculations for the impact on clinician behaviour and possible excess cost due to litigation regarding pregabalin.
DOI: 10.6084/m9.figshare.5895847.v2
title: The clinician impact and financial cost to the NHS of litigation over pregabalin - a Jupyter notebook

description: A notebook containing the calculations for the impact on clinician behaviour and possible excess cost due to litigation regarding pregabalin.
DOI: 10.6084/m9.figshare.5895796
title: "Selective outcome reporting in pediatric anesthesiology literature: a cross-sectional analysis" fileset

description: Tables, figures, and files for "Selective outcome reporting in pediatric anesthesiology literature: a cross-sectional analysis"<br>Please note: Author names and study titles removed from "Registered and Published [Primary/Secondary] Outcomes Comparison by (Anonymous) Authors" files to maintain anonymity as stated in "Template for email to authors." Also, note that the "RCT #" for each anonymous RCT in these same files do not necessarily correspond to each similarly named "RCT #" between each comparison file.
DOI: 10.6084/m9.figshare.5895796.v1
title: "Selective outcome reporting in pediatric anesthesiology literature: a cross-sectional analysis" fileset

description: Tables, figures, and files for "Selective outcome reporting in pediatric anesthesiology literature: a cross-sectional analysis"<br>Please note: Author names and study titles removed from "Registered and Published [Primary/Secondary] Outcomes Comparison by (Anonymous) Authors" files to maintain anonymity as stated in "Template for email to authors." Also, note that the "RCT #" for each anonymous RCT in these same files do not necessarily correspond to each similarly named "RCT #" between each comparison file.
DOI: 10.6084/m9.figshare.5895757
title: Supplemental_figures.pdf

description: Supplemental information
DOI: 10.6084/m9.figshare.5895586
title: Data-PlosOne-2018.xlsx

description: <b>Supporting information file</b>
DOI: 10.6084/m9.figshare.5895586.v1
title: Data-PlosOne-2018.xlsx

description: <b>Supporting information file</b>
DOI: 10.6084/m9.figshare.5895496
title: Multicenter double-blind randomized controlled trial to evaluate the effectiveness and safety of bortezomib as a treatment for refractory systemic lupus erythematosus

description: <b>Objectives:</b> The objective of this study is to evaluate the efficacy and safety of bortezomib for treating systemic lupus erythematosus (SLE), in patients whose disease activity could not be controlled. <b>Methods:</b> Fourteen SLE patients with persistent disease activity were selected, who required prednisolone doses of &gt;10 mg/d despite concomitant immunosuppressive therapy. Patients were randomly administered either bortezomib or a placebo, eight times. The primary and secondary end-points were a change in anti-dsDNA antibody titer at week 24 and the SLE Responder Index (SRI), respectively. <b>Results:</b> In the bortezomib group, four out of eight patients discontinued the trial; three others failed to complete the minimum protocol treatment due to adverse reactions. The changes in anti-dsDNA antibody titers at week 24 were 4.24% and −1.96%, for the bortezomib and placebo groups, respectively, disconfirming bortezomib’s efficacy. In contrast, the corresponding SRI at week 12 was 75% and 40%. <b>Conclusions:</b> As bortezomib therapy for SLE is associated with many adverse reactions, treatment indications should be selected carefully, and protocols should aim to prevent these occurrences. Although the change in anti-dsDNA antibody titer did not support the efficacy of bortezomib as a treatment for SLE, high SRI in the treatment group suggests bortezomib may utilize mechanisms other than inhibition of anti-dsDNA antibody production.
DOI: 10.6084/m9.figshare.5895496.v1
title: Multicenter double-blind randomized controlled trial to evaluate the effectiveness and safety of bortezomib as a treatment for refractory systemic lupus erythematosus

description: <b>Objectives:</b> The objective of this study is to evaluate the efficacy and safety of bortezomib for treating systemic lupus erythematosus (SLE), in patients whose disease activity could not be controlled. <b>Methods:</b> Fourteen SLE patients with persistent disease activity were selected, who required prednisolone doses of &gt;10 mg/d despite concomitant immunosuppressive therapy. Patients were randomly administered either bortezomib or a placebo, eight times. The primary and secondary end-points were a change in anti-dsDNA antibody titer at week 24 and the SLE Responder Index (SRI), respectively. <b>Results:</b> In the bortezomib group, four out of eight patients discontinued the trial; three others failed to complete the minimum protocol treatment due to adverse reactions. The changes in anti-dsDNA antibody titers at week 24 were 4.24% and −1.96%, for the bortezomib and placebo groups, respectively, disconfirming bortezomib’s efficacy. In contrast, the corresponding SRI at week 12 was 75% and 40%. <b>Conclusions:</b> As bortezomib therapy for SLE is associated with many adverse reactions, treatment indications should be selected carefully, and protocols should aim to prevent these occurrences. Although the change in anti-dsDNA antibody titer did not support the efficacy of bortezomib as a treatment for SLE, high SRI in the treatment group suggests bortezomib may utilize mechanisms other than inhibition of anti-dsDNA antibody production.
DOI: 10.6084/m9.figshare.5894584
title: PNAS_paper.zip

description: The zip folder PNAS_paper contains the original ibw files for Figs 2, 3 and S1 for the recently accepted paper: Al-Rekabi Z & Contera S. 2018. PNAS. (accepted).