cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.34808/nyq1-6188
title: Liposarcoma, well differentiated, NOS - Female, 60 - Tissue image [531073001584481]

description: This is the histopathological image of RETROPERITONEUM AND PERITONEUM tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format. The detailed information about the patient, sample, and diagnosis are as follows: Patient:Age: 60Clinical description: Tumor of the retroperitoneal space.Gender: FemaleDiagnosis:Classification: ICD-O_3.2Classification code: LIPOMATOUS NEOPLASMSDiagnosis: Liposarcoma, well differentiated, NOSResult of the histopathological examination: Well-differentiated liposarcoma.
IHC: PAS+; MyoD1 (-), CD34 (+), S100 (+) in single cells, SMA (-), Ki67 index low, MDM2 +/-.Sample:Material: FFPECollecting method: Surgical specimenTopography: RETROPERITONEUM AND PERITONEUMOrgan: RETROPERITONEUM AND PERITONEUMTissue: RetroperitoneumType of staining: positive/HEStaining: Not applicableAntibody: Not applicableTechnology:Equipment: Pannoramic 250 3DHistechLens: 20xOrganization:Source: Medical University Gdańsk
DOI: 10.34808/db03-w781
title: Invasive breast carcinoma of no special type - Female, 50 - Tissue image [5310730015839211]

description: This is the histopathological image of BREAST tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: VS200 Olympus slide scanner (20x magnification) and saved to DICOM format. The detailed information about the patient, sample, and diagnosis are as follows: Patient:Age: 50Clinical description: Breast tumourGender: FemaleDiagnosis:Classification: ICD-O_3.2Classification code: DUCTAL AND LOBULAR NEOPLASMSDiagnosis: Invasive breast carcinoma of no special typeResult of the histopathological examination: Invasive breast carcinoma of no special type, G2. Nottingham: tubular formation - 2 point, atypia -2 point, mitosis - 3 point. There was no neuro or angioinvasion.

IHC: ER 8/8 (+++ in 80% of FQ), PR 5/8 (+++ in 25% of FQ), HER-2 1+ (negative), index Ki67 40-50%, e-cadherin + , p120 + (membranous and cytoplasmic).

The infiltrate is located 2.5 mm from the front surgical margin and 3 mm from the surgical margin on the fascia.
Additionally, foci of ductal carcinoma in situ (DCIS), NG2, with solid, ethmoid and comedo-like necrosis, with visible microcalcifications. DCIS foci are approximately 1mm from the fascia surgical margin.Sample:Material: FFPECollecting method: Surgical specimenTopography: BREASTOrgan: BREASTTissue: Breast, NOSType of staining: positive/IHCStaining: Not applicableAntibody: Ki-67Technology:Equipment: VS200 OlympusLens: 20xOrganization:Source: Medical University Gdańsk
DOI: 10.34808/qz60-mk62
title: Abdominal pregnancy - Female, 0 - Tissue image [531073001584271]

description: This is the histopathological image of PLACENTA tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format. The detailed information about the patient, sample, and diagnosis are as follows: Patient:Age: 0Clinical description: Obsolete pregnancy Hbd 19Gender: FemaleDiagnosis:Classification: ICD-10_10-20Classification code: Chapter XV - Pregnancy, childbirth and the puerperiumDiagnosis: Abdominal pregnancyResult of the histopathological examination: Placental parenchyma appropriate for gestational age with areas of bleeding and hyalinisation in the placenta.Sample:Material: FFPECollecting method: Surgical specimenTopography: FEMALE GENITAL ORGANSOrgan: PLACENTATissue: PlacentaType of staining: positive/HEStaining: Not applicableAntibody: Not applicableTechnology:Equipment: Pannoramic 250 3DHistechLens: 20xOrganization:Source: Medical University Gdańsk
DOI: 10.34808/v8av-k860
title: Invasive breast carcinoma of no special type - Female, 50 - Tissue image [5310730015836851]

description: This is the histopathological image of BREAST tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: VS200 Olympus slide scanner (20x magnification) and saved to DICOM format. The detailed information about the patient, sample, and diagnosis are as follows: Patient:Age: 50Clinical description: Breast tumourGender: FemaleDiagnosis:Classification: ICD-O_3.2Classification code: DUCTAL AND LOBULAR NEOPLASMSDiagnosis: Invasive breast carcinoma of no special typeResult of the histopathological examination: Invasive breast carcinoma of no special type, G2. Nottingham: tubular formation - 2 point, atypia -2 point, mitosis - 3 point. There was no neuro or angioinvasion.

IHC: ER 8/8 (+++ in 80% of FQ), PR 5/8 (+++ in 25% of FQ), HER-2 1+ (negative), index Ki67 40-50%, e-cadherin + , p120 + (membranous and cytoplasmic).

The infiltrate is located 2.5 mm from the front surgical margin and 3 mm from the surgical margin on the fascia.
Additionally, foci of ductal carcinoma in situ (DCIS), NG2, with solid, ethmoid and comedo-like necrosis, with visible microcalcifications. DCIS foci are approximately 1mm from the fascia surgical margin.Sample:Material: FFPECollecting method: Surgical specimenTopography: BREASTOrgan: BREASTTissue: Breast, NOSType of staining: positive/IHCStaining: Not applicableAntibody: CK 14Technology:Equipment: VS200 OlympusLens: 20xOrganization:Source: Medical University Gdańsk
DOI: 10.34808/s6vq-8z18
title: Abdominal pregnancy - Female, 0 - Tissue image [5310730015842661]

description: This is the histopathological image of OTHER AND ILL-DEFINED SITES tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format. The detailed information about the patient, sample, and diagnosis are as follows: Patient:Age: 0Clinical description: Obsolete pregnancy, Hbd 18, triploidy in FISHGender: FemaleDiagnosis:Classification: ICD-10_10-20Classification code: Chapter XV - Pregnancy, childbirth and the puerperiumDiagnosis: Abdominal pregnancyResult of the histopathological examination: Two-vessel umbilical cord with signs of vascular inflammation.Sample:Material: FFPECollecting method: Autopsy specimenTopography: OTHER AND ILL-DEFINED SITESOrgan: OTHER AND ILL-DEFINED SITESTissue: Abdominal wall, NOSType of staining: positive/HEStaining: Not applicableAntibody: Not applicableTechnology:Equipment: Pannoramic 250 3DHistechLens: 20xOrganization:Source: Medical University Gdańsk
DOI: 10.34808/7gp7-p510
title: Other placental disorders - Female, 33 - Tissue image [5310730015844041]

description: This is the histopathological image of PLACENTA tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format. The detailed information about the patient, sample, and diagnosis are as follows: Patient:Age: 33Clinical description: Grav II, Hbd 40Gender: FemaleDiagnosis:Classification: ICD-10_10-20Classification code: Chapter XV - Pregnancy, childbirth and the puerperiumDiagnosis: Other placental disordersResult of the histopathological examination: Mature placenta with purulent infection with ascending villitis and subacute infarction.Sample:Material: FFPECollecting method: Surgical specimenTopography: FEMALE GENITAL ORGANSOrgan: PLACENTATissue: PlacentaType of staining: positive/HEStaining: Not applicableAntibody: Not applicableTechnology:Equipment: Pannoramic 250 3DHistechLens: 20xOrganization:Source: Medical University Gdańsk
DOI: 10.34808/zpjs-q907
title: Liposarcoma, well differentiated, NOS - Female, 60 - Tissue image [5310730015845621]

description: This is the histopathological image of RETROPERITONEUM AND PERITONEUM tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format. The detailed information about the patient, sample, and diagnosis are as follows: Patient:Age: 60Clinical description: Tumor of the retroperitoneal space.Gender: FemaleDiagnosis:Classification: ICD-O_3.2Classification code: LIPOMATOUS NEOPLASMSDiagnosis: Liposarcoma, well differentiated, NOSResult of the histopathological examination: Well-differentiated liposarcoma.
IHC: PAS+; MyoD1 (-), CD34 (+), S100 (+) in single cells, SMA (-), Ki67 index low, MDM2 +/-.Sample:Material: FFPECollecting method: Surgical specimenTopography: RETROPERITONEUM AND PERITONEUMOrgan: RETROPERITONEUM AND PERITONEUMTissue: RetroperitoneumType of staining: positive/HEStaining: Not applicableAntibody: Not applicableTechnology:Equipment: Pannoramic 250 3DHistechLens: 20xOrganization:Source: Medical University Gdańsk
DOI: 10.34808/277y-p859
title: Liposarcoma, well differentiated, NOS - Female, 60 - Tissue image [5310730015843461]

description: This is the histopathological image of RETROPERITONEUM AND PERITONEUM tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format. The detailed information about the patient, sample, and diagnosis are as follows: Patient:Age: 60Clinical description: Tumor of the retroperitoneal space.Gender: FemaleDiagnosis:Classification: ICD-O_3.2Classification code: LIPOMATOUS NEOPLASMSDiagnosis: Liposarcoma, well differentiated, NOSResult of the histopathological examination: Well-differentiated liposarcoma.
IHC: PAS+; MyoD1 (-), CD34 (+), S100 (+) in single cells, SMA (-), Ki67 index low, MDM2 +/-.Sample:Material: FFPECollecting method: Surgical specimenTopography: RETROPERITONEUM AND PERITONEUMOrgan: RETROPERITONEUM AND PERITONEUMTissue: RetroperitoneumType of staining: positive/IHCStaining: Not applicableAntibody: MDM-2Technology:Equipment: Pannoramic 250 3DHistechLens: 20xOrganization:Source: Medical University Gdańsk
DOI: 10.34808/bwtd-1r51
title: Liposarcoma, well differentiated, NOS - Female, 60 - Tissue image [5310730015845381]

description: This is the histopathological image of RETROPERITONEUM AND PERITONEUM tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format. The detailed information about the patient, sample, and diagnosis are as follows: Patient:Age: 60Clinical description: Tumor of the retroperitoneal space.Gender: FemaleDiagnosis:Classification: ICD-O_3.2Classification code: LIPOMATOUS NEOPLASMSDiagnosis: Liposarcoma, well differentiated, NOSResult of the histopathological examination: Well-differentiated liposarcoma.
IHC: PAS+; MyoD1 (-), CD34 (+), S100 (+) in single cells, SMA (-), Ki67 index low, MDM2 +/-.Sample:Material: FFPECollecting method: Surgical specimenTopography: RETROPERITONEUM AND PERITONEUMOrgan: RETROPERITONEUM AND PERITONEUMTissue: RetroperitoneumType of staining: positive/HEStaining: Not applicableAntibody: Not applicableTechnology:Equipment: Pannoramic 250 3DHistechLens: 20xOrganization:Source: Medical University Gdańsk
DOI: 10.34808/t8e3-5q25
title: Serous cystadenocarcinoma, NOS - Female, 66 - Tissue image [53107300158321]

description: This is the histopathological image of OVARY tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format. The detailed information about the patient, sample, and diagnosis are as follows: Patient:Age: 66Clinical description: Ovarian cancerGender: FemaleDiagnosis:Classification: ICD-O_3.2Classification code: CYSTIC, MUCINOUS AND SEROUS NEOPLASMSDiagnosis: Serous cystadenocarcinoma, NOSResult of the histopathological examination: Low-differentiated serous carcinoma of the ovary with peritoneal metastases of pericolic runoff.Sample:Material: FFPECollecting method: Surgical specimenTopography: FEMALE GENITAL ORGANSOrgan: OVARYTissue: OvaryType of staining: positive/HEStaining: Not applicableAntibody: Not applicableTechnology:Equipment: Pannoramic 250 3DHistechLens: 20xOrganization:Source: Medical University Gdańsk
DOI: 10.34808/7exs-gk79
title: Serous cystadenocarcinoma, NOS - Female, 66 - Tissue image [5310730015833881]

description: This is the histopathological image of OVARY tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format. The detailed information about the patient, sample, and diagnosis are as follows: Patient:Age: 66Clinical description: Ovarian cancerGender: FemaleDiagnosis:Classification: ICD-O_3.2Classification code: CYSTIC, MUCINOUS AND SEROUS NEOPLASMSDiagnosis: Serous cystadenocarcinoma, NOSResult of the histopathological examination: Low-differentiated serous carcinoma of the ovary with peritoneal metastases of pericolic runoff.Sample:Material: FFPECollecting method: Surgical specimenTopography: FEMALE GENITAL ORGANSOrgan: OVARYTissue: OvaryType of staining: positive/HEStaining: Not applicableAntibody: Not applicableTechnology:Equipment: Pannoramic 250 3DHistechLens: 20xOrganization:Source: Medical University Gdańsk
DOI: 10.6084/m9.figshare.19941358
title: Cytogenomics Investigation of Infants with Congenital Heart Disease: Experience of a Brazilian Center

description: Abstract Background Some syndromes have specific and easily recognizable features, while others may be more complex to identify and may present different phenotypic manifestations, for example. An etiological diagnosis is important to understand the nature of the disease, to establish the prognosis and to start the treatment, allowing the inclusion of patients in society and reducing the financial cost of such diseases. Objective The initial proposal of this study was cytogenetic screening for the detection of the 22q11.2 deletion syndrome in consecutive newborns and infants with congenital heart disease using the multiplex ligation-dependent probe amplification (MLPA) technique. Therefore, throughout our research, other genomic alterations were identified in these cardiac patients. Thus, our objective was extended to investigate these other cytogenetic alterations. Methods We investigated 118 neonates with congenital heart diseases born consecutively during one year using the MLPA technique. Results The MLPA technique allowed the detection of 22q11.2DS in 10/118 patients (8.5%). Other genomic alterations were also identified in 6/118 patients (5%): 1p36 del, 8p23 del (2 cases), 7q dup, 12 dup and 8q24 dup. Conclusion This study highlights the relevance of detecting genomic alterations that are present in newborns and infants with congenital cardiac diseases using cytogenomic tools.
DOI: 10.6084/m9.figshare.19941358.v1
title: Cytogenomics Investigation of Infants with Congenital Heart Disease: Experience of a Brazilian Center

description: Abstract Background Some syndromes have specific and easily recognizable features, while others may be more complex to identify and may present different phenotypic manifestations, for example. An etiological diagnosis is important to understand the nature of the disease, to establish the prognosis and to start the treatment, allowing the inclusion of patients in society and reducing the financial cost of such diseases. Objective The initial proposal of this study was cytogenetic screening for the detection of the 22q11.2 deletion syndrome in consecutive newborns and infants with congenital heart disease using the multiplex ligation-dependent probe amplification (MLPA) technique. Therefore, throughout our research, other genomic alterations were identified in these cardiac patients. Thus, our objective was extended to investigate these other cytogenetic alterations. Methods We investigated 118 neonates with congenital heart diseases born consecutively during one year using the MLPA technique. Results The MLPA technique allowed the detection of 22q11.2DS in 10/118 patients (8.5%). Other genomic alterations were also identified in 6/118 patients (5%): 1p36 del, 8p23 del (2 cases), 7q dup, 12 dup and 8q24 dup. Conclusion This study highlights the relevance of detecting genomic alterations that are present in newborns and infants with congenital cardiac diseases using cytogenomic tools.
DOI: 10.6084/m9.figshare.19941359
title: Thrombolytic Therapy in Octogenarians with Acute Pulmonary Embolism

description: Abstract Background Despite the high proportion of octogenarians with acute pulmonary embolism, there is little information indicating the optimal management strategy, mainly therapeutic measures, such as lytic therapy. Objectives The number of elderly patients diagnosed with acute pulmonary embolism increases constantly. However, the role of thrombolytic treatment is not clearly defined among octogenarians. Our objective is to evaluate the effectiveness of lytic therapy in octogenarian patients diagnosed with pulmonary embolism. Methods One hundred and forty eight subjects (70.3% women, n=104) aged more than eighty years were included in the study. The patients were divided in two groups: thrombolytic versus non-thrombolytic treatment. In-hospital mortality rates and bleeding events were defined as study outcomes. P-value &lt;0.05 was considered as statistical significance. Results In-hospital mortality decreased significantly in the thrombolytic group compared to the non-thrombolytic group (10.5% vs. 24.2% p=0.03). Minor bleeding events were more common in the arm that received thrombolytic treatment, but major hemorrhage did not differ between the groups (35.1% vs. 13.2%, p&lt;0.01; 7% vs. 5.5% p=0.71, respectively). High PESI score (OR: 1.03 95%CI; 1.01-1.04 p&lt;0.01), thrombolytic therapy (OR: 0.15 95%CI; 0.01-0.25, p&lt; 0.01) and high troponin levels (OR: 1.20 95%CI; 1.01-1.43, p=0.03) were independently associated with in-hospital mortality rates in the multivariate regression analysis. Conclusion Thrombolytic therapy was associated with reduced in-hospital mortality at the expense of increased overall bleeding complications in octogenarians.
DOI: 10.6084/m9.figshare.19941359.v1
title: Thrombolytic Therapy in Octogenarians with Acute Pulmonary Embolism

description: Abstract Background Despite the high proportion of octogenarians with acute pulmonary embolism, there is little information indicating the optimal management strategy, mainly therapeutic measures, such as lytic therapy. Objectives The number of elderly patients diagnosed with acute pulmonary embolism increases constantly. However, the role of thrombolytic treatment is not clearly defined among octogenarians. Our objective is to evaluate the effectiveness of lytic therapy in octogenarian patients diagnosed with pulmonary embolism. Methods One hundred and forty eight subjects (70.3% women, n=104) aged more than eighty years were included in the study. The patients were divided in two groups: thrombolytic versus non-thrombolytic treatment. In-hospital mortality rates and bleeding events were defined as study outcomes. P-value &lt;0.05 was considered as statistical significance. Results In-hospital mortality decreased significantly in the thrombolytic group compared to the non-thrombolytic group (10.5% vs. 24.2% p=0.03). Minor bleeding events were more common in the arm that received thrombolytic treatment, but major hemorrhage did not differ between the groups (35.1% vs. 13.2%, p&lt;0.01; 7% vs. 5.5% p=0.71, respectively). High PESI score (OR: 1.03 95%CI; 1.01-1.04 p&lt;0.01), thrombolytic therapy (OR: 0.15 95%CI; 0.01-0.25, p&lt; 0.01) and high troponin levels (OR: 1.20 95%CI; 1.01-1.43, p=0.03) were independently associated with in-hospital mortality rates in the multivariate regression analysis. Conclusion Thrombolytic therapy was associated with reduced in-hospital mortality at the expense of increased overall bleeding complications in octogenarians.
DOI: 10.18112/openneuro.ds004086.v1.0.1
title: Triple Dissociation Revisited
DOI: 10.6084/m9.figshare.19941338
title: primary data.xlsx

description: Data from transect in Southern Bohemia
DOI: 10.6084/m9.figshare.19941338.v1
title: primary data.xlsx

description: Data from transect in Southern Bohemia
DOI: 10.6084/m9.figshare.19941365
title: Interleukin-35 Levels in Patients with Stable Coronary Artery Disease

description: Abstract Background It has been shown that interleukin-35 (IL-35) subunits are strongly expressed in atherosclerotic plaques in humans. Therefore, it is considered to play a role in atherosclerosis. Objectives In this study, IL-35 levels were compared with the control group in patients with stable coronary artery disease (CAD), and the association between IL-35 levels and the lesion type, lesion severity and extension was investigated with the Gensini score (GS) and the Syntax score (SS) in the patient group. Methods Sixty patients (18 female and 42 male) with CAD diagnosed by coronary angiography, who presented with typical chest pain and positive noninvasive cardiac stress test, and 46 patients (18 female and 28 male) with normal coronary lumenogram, were included in this study. Gensini and Syntax scores were calculated in the patient group, and these values were compared with IL-35 levels. Non-normally distributed variables were analyzed by the Mann-Whitney U test, whereas normally distributed parameters were assessed by Student’s t-test. The difference between categorical variables were evaluated by the Chi-square or Fisher test. P-values&lt;0.05 were considered as statistically significant. Results No significant differences were observed between patients and the control group in terms of demographic characteristics and laboratory findings. Compared to the control group, IL-35 levels of the CAD group were considerably lower (36.9±63.9 ng/ml vs. 33.2±13.2 ng/ml, p&lt;0.008). Although not statistically significant, IL-35 levels were higher in patients with low SS than among those with high SS (33.2±13.7 vs. 31.8±8.9, p=0.51). The IL-35 values of the patients with high GS were significantly lower than in patients with low GS (35±17.4 vs. 30.7±8.6, p=0.043). Conclusion It has been shown that IL-35 levels can be a new biomarker for stable CAD, and IL-35 is associated with the extension of CAD.