cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.5517/ccdc.csd.cc24zhk6
title: CCDC 1995518: Experimental Crystal Structure Determination

description: Related Article: Alejandro Portugués, Lydia González, Delia Bautista, Juan Gil-Rubio|2020|Angew.Chem.,Int.Ed.|59|15220|doi:10.1002/anie.202006440
DOI: 10.6084/m9.figshare.5904022.v1
title: Qatar Metabolomics Study on Diabetes

description: The Qatar Metabolomics Study on Diabetes (QMDiab) is a type 2 diabetes case-control, which was conducted in 2012 at the Dermatology Department of Hamad Medical Corporation and the Weill Cornell Medical College in Doha, Qatar. The study was approved by the Institutional Review Boards of HMC and WCM-Q under research protocol number 11131/11. All study participants provided written informed consent.<br><br>Untargeted metabolomics measurements (LC/MS+, LC/MS-, and GC/MS) from plasma, urine, and saliva samples of 374 participants, which are aged 17-81 years, were performed by Metabolon Inc.<br><br>The OrigScale dataset comprises median-scaled data for each body fluid. The Preprocessed dataset comprises missing values treated, normalized, transformed, and scaled data. In both datasets, rows correspond to participants (anonymized) and columns correspond to metabolites. <br><br>Phenotype information (type 2 diabetes status, age, gender, BMI, ethnicity) are available as the last six columns of each dataset.<br>Annotations and pathway assigments are also provided for each metabolite.
DOI: 10.21942/uva.5904010.v2
title: MAGs-KEGG

description: KEGG-number assignment for 871 metagenome-assembled genomes (MAGs) from hypersaline soda lake sediments in the Kulunda Steppe (Siberia, Russia).<br>KO-numbers can be used for reconstruction and visualization of metabolic pathways (http://www.genome.jp/kegg/tool/map_pathway.html), and contigs (without annotation) can be retrieved from NCBI (BioProject ID PRJNA434545).
DOI: 10.21942/uva.5903887.v1
title: Figure_2-3

description: Alignments (.mafft) were made based on 8-16 ribosomal proteins of 871 MAGs reconstructed from metagenomes from hypersaline soda lake sediments and reference genomes used to construct a tree of life (Hug, L. A., Baker, B. J., Anantharaman, K., Brown, C. T., Probst, A. J., Castelle, C. J., ... & Suzuki, Y. (2016). A new view of the tree of life. <i>Nature microbiology</i>, <i>1</i>, 16048.).Phylogenetic trees were constructed with Fasttree and 100x posterior bootstraps were calculated (.tre).Trees and metadata can be visualized in iTOL (https://itol.embl.de) with the accompanied datafiles (.txt)
DOI: 10.6084/m9.figshare.5903848
title: Supplementary Material for: Anti- Versus Pro-Inflammatory Metabololipidome Upon Cupping Treatment

description: <b><i>Background/Aims:</i></b> This study aimed to explore the metabololipidome in mice upon cupping treatment. <b><i>Methods:</i></b> A nude mouse model mimicking the cupping treatment in humans was established by administrating four cupping sets on the back skin for 15 minutes. UPLC-MS/ MS was performed to determine the PUFA metabolome in mice skin and blood before and after cupping treatment. The significantly changed lipids were administered in macrophages to assess the production of pro-inflammatory cytokines IL-6 and TNF-α by ELISA. <b><i>Results:</i></b> The anti-inflammatory lipids, <i>e.g</i>. PGE<sub>1</sub>, 5,6-EET, 14,15-EET, 10S,17S-DiHDoHE, 17R-RvD1, RvD5 and 14S-HDoHE were significantly increased while pro-inflammatory lipids, <i>e.g</i>. 12-HETE and TXB<sub>2</sub> were deceased in the skin or plasma post cupping treatment. Cupping treatment reversed the LPS-stimulated IL-6 and TNF-α expression in mouse peritoneal exudates. Moreover, 5,6-EET, PGE<sub>1</sub> decreased the level of TNF-α, while 5,6-EET, 5,6-DHET downregulated IL-6 production in macrophages. Importantly, 14,15-EET and 14S-HDoHE inhibited both IL-6 and TNF-α induced by lipopolysaccharide (LPS). 17-RvD1, RvD5 and PGE<sub>1</sub> significantly reduced the LPS-initiated TNF-α, while TXB<sub>2</sub> and 12-HETE further upregulated the LPS-enhanced IL-6 and TNF-α expression in macrophages. <b><i>Conclusion:</i></b> Our results reveal the identities of anti-inflammatory <i>versus</i> pro-inflammatory metabolipidome and suggest the potential therapeutic mechanism of cupping treatment.
DOI: 10.21942/uva.5903794.v1
title: CPR-annotations

description: These 73 MAGs were recovered from the metagenomes of hypersaline soda lake sediments in the Kulunda Steppe (Siberia, Russian Federation).
DOI: 10.6084/m9.figshare.5903755
title: The Roles of Convection Parameterization in the Formation of Double ITCZ Syndrome in the NCAR CESM Part I: Atmospheric Processes

description: CESM1.2.1 simulation data set<br>
DOI: 10.6084/m9.figshare.5903755.v1
title: The Roles of Convection Parameterization in the Formation of Double ITCZ Syndrome in the NCAR CESM Part I: Atmospheric Processes

description: CESM1.2.1 simulation data set<br>
DOI: 10.6084/m9.figshare.5903716
title: Supplementary Material for: Consumption of Amaranth Induces the Accumulation of the Antioxidant Protein Paraoxonase/Arylesterase 1 and Modulates Dipeptidyl Peptidase IV Activity in Plasma of Streptozotocin-Induced Hyperglycemic Rats

description: <b><i>Background/Aim:</i></b> Amaranth is a source of several bioactive compounds, among which peptides with inhibitory activity upon dipeptidyl peptidase IV (DPP-IV) have been reported. However, there is no information about the action of amaranth DPP-IV-inhibitory peptides using in vivo models. The aim of this work was to evaluate the effect of amaranth consumption on plasma and kidney DPP-IV activity as well the changes in plasma proteome profile of streptozotocin (STZ)-induced hyperglycemic rats. <b><i>Methods:</i></b> Rats were fed for 12 weeks with a diet containing 20% popped amaranth grain. Kidneys and blood samples were collected for lipid profile, DPP-IV activity and expression, and proteomic analysis. <b><i>Results:</i></b> Total cholesterol and DPP-IV activity in plasma was increased in hyperglycemic rats, but this effect was reverted by amaranth consumption. Triacylglycerols were increased in the hyperglycemic group fed amaranth, and the highest levels of high-density lipoproteins were also observed in this group. These data correlated with the accumulation of apolipoprotein A-II in plasma. Accumulation of the antioxidant protein paraoxonase/arylesterase 1 in STZ-induced hyperglycemic rats was observed when amaranth was supplied in the diet. <b><i>Conclusion:</i></b> This study provides new insights into the molecular mechanisms by which amaranth exerts its beneficial health action in a hyperglycemic state.
DOI: 10.6084/m9.figshare.5903716.v1
title: Supplementary Material for: Consumption of Amaranth Induces the Accumulation of the Antioxidant Protein Paraoxonase/Arylesterase 1 and Modulates Dipeptidyl Peptidase IV Activity in Plasma of Streptozotocin-Induced Hyperglycemic Rats

description: <b><i>Background/Aim:</i></b> Amaranth is a source of several bioactive compounds, among which peptides with inhibitory activity upon dipeptidyl peptidase IV (DPP-IV) have been reported. However, there is no information about the action of amaranth DPP-IV-inhibitory peptides using in vivo models. The aim of this work was to evaluate the effect of amaranth consumption on plasma and kidney DPP-IV activity as well the changes in plasma proteome profile of streptozotocin (STZ)-induced hyperglycemic rats. <b><i>Methods:</i></b> Rats were fed for 12 weeks with a diet containing 20% popped amaranth grain. Kidneys and blood samples were collected for lipid profile, DPP-IV activity and expression, and proteomic analysis. <b><i>Results:</i></b> Total cholesterol and DPP-IV activity in plasma was increased in hyperglycemic rats, but this effect was reverted by amaranth consumption. Triacylglycerols were increased in the hyperglycemic group fed amaranth, and the highest levels of high-density lipoproteins were also observed in this group. These data correlated with the accumulation of apolipoprotein A-II in plasma. Accumulation of the antioxidant protein paraoxonase/arylesterase 1 in STZ-induced hyperglycemic rats was observed when amaranth was supplied in the diet. <b><i>Conclusion:</i></b> This study provides new insights into the molecular mechanisms by which amaranth exerts its beneficial health action in a hyperglycemic state.
DOI: 10.6084/m9.figshare.5903623
title: A Review of Recent Advances Using Tocilizumab in the Treatment of Rheumatic Diseases

description: <b> </b> <b>Article full text</b><br>The full text of this article can be found here<b>.</b> https://link.springer.com/article/10.1007/s40744-018-0102-x<br><b>Provide enhanced content for this article</b><br>If you are an author of this publication and would like to provide additional enhanced content for your article then please contact <b>adisrapidplus@springer.com</b>.<br>The journal offers a range of additional features designed to increase visibility and readership. All features will be thoroughly peer reviewed to ensure the content is of the highest scientific standard and all features are marked as ‘peer reviewed’ to ensure readers are aware that the content has been reviewed to the same level as the articles they are being presented alongside. Moreover, all sponsorship and disclosure information is included to provide complete transparency and adherence to good publication practices. This ensures that however the content is reached the reader has a full understanding of its origin. No fees are charged for hosting additional open access content.<br>Other enhanced features include, but are not limited to:<br>• Slide decks• Videos and animations• Audio abstracts • Audio slides
DOI: 10.6084/m9.figshare.5903623.v3
title: A Review of Recent Advances Using Tocilizumab in the Treatment of Rheumatic Diseases

description: <b> </b> <b>Article full text</b><br>The full text of this article can be found here<b>.</b> https://link.springer.com/article/10.1007/s40744-018-0102-x<br><b>Provide enhanced content for this article</b><br>If you are an author of this publication and would like to provide additional enhanced content for your article then please contact <b>adisrapidplus@springer.com</b>.<br>The journal offers a range of additional features designed to increase visibility and readership. All features will be thoroughly peer reviewed to ensure the content is of the highest scientific standard and all features are marked as ‘peer reviewed’ to ensure readers are aware that the content has been reviewed to the same level as the articles they are being presented alongside. Moreover, all sponsorship and disclosure information is included to provide complete transparency and adherence to good publication practices. This ensures that however the content is reached the reader has a full understanding of its origin. No fees are charged for hosting additional open access content.<br>Other enhanced features include, but are not limited to:<br>• Slide decks• Videos and animations• Audio abstracts • Audio slides
DOI: 10.6084/m9.figshare.5903623.v2
title: A Review of Recent Advances Using Tocilizumab in the Treatment of Rheumatic Diseases

description: <b> </b> <b>Article full text</b><br>The full text of this article can be found here<b>.</b> https://link.springer.com/article/10.1007/s40744-018-0102-x<br><b>Provide enhanced content for this article</b><br>If you are an author of this publication and would like to provide additional enhanced content for your article then please contact <b>adisrapidplus@springer.com</b>.<br>The journal offers a range of additional features designed to increase visibility and readership. All features will be thoroughly peer reviewed to ensure the content is of the highest scientific standard and all features are marked as ‘peer reviewed’ to ensure readers are aware that the content has been reviewed to the same level as the articles they are being presented alongside. Moreover, all sponsorship and disclosure information is included to provide complete transparency and adherence to good publication practices. This ensures that however the content is reached the reader has a full understanding of its origin. No fees are charged for hosting additional open access content.<br>Other enhanced features include, but are not limited to:<br>• Slide decks• Videos and animations• Audio abstracts • Audio slides
DOI: 10.6084/m9.figshare.5903599
title: Supplementary Material for: Early Psychological Counseling for the Prevention of Posttraumatic Stress Induced by Acute Coronary Syndrome: The MI-SPRINT Randomized Controlled Trial

description: <b><i>Background:</i></b> Acute coronary syndrome (ACS)-induced posttraumatic stress disorder (PTSD) and clinically significant PTSD symptoms (PTSS) are found in 4 and 12% of patients, respectively. We hypothesized that trauma-focused counseling prevents the incidence of ACS-induced PTSS. <b><i>Methods:</i></b> Within 48 h of hospital admission, 190 patients with high distress during ACS were randomized to a single-session intervention of either trauma-focused counseling or an active control intervention targeting the general role of stress in patients with heart disease. Blind interviewer-rated PTSS (primary outcome) and additional health outcomes were assessed at 3 months of follow-up. Trial results about prevalence were compared with data from previous studies on the natural incidence of ACS-induced PTSS/PTSD. <b><i>Results:</i></b> Intention-to-treat analyses revealed no difference in interviewer-rated PTSS between trauma-focused counseling (mean, 11.33; 95% Cl, 9.23-13.43) and stress counseling (9.88; 7.36-12.40; <i>p</i> = 0.40), depressive symptoms (6.01, 4.98-7.03, vs. 4.71, 3.65-5.77; <i>p</i> = 0.08), global psychological distress (5.15, 4.07-6.23, vs. 3.80, 2.60-5.00; <i>p</i> = 0.11), and the risk for cardiovascular-related hospitalization/all-cause mortality (OR, 0.67; 95% CI, 0.37-1.23). Self-rated PTSS indicated less beneficial effects with trauma-focused (6.54; 4.95-8.14) versus stress counseling (3.74; 2.39-5.08; <i>p</i> = 0.017). The completer analysis (154 cases) confirmed these findings. The prevalence rates of interviewer-rated PTSD (0.5%, 1/190) and self-rated PTSS were in this trial much lower than in meta-analyses and observation studies from the same cardiology department. <b><i>Conclusions:</i></b> Benefits were not seen for trauma-focused counseling when compared with an active control intervention. Nonetheless, in distressed ACS patients, individual, single-session, early psychological counseling shows potential as a means to prevent posttraumatic responses, but trauma-focused early treatments should probably be avoided.
DOI: 10.6084/m9.figshare.5903593
title: Supplementary Material for: The Return of Fear: Variation of the Serotonin Transporter Gene Predicts Outcome of a Highly Standardized Exposure-Based One-Session Fear Treatment

description: <b><i>Background:</i></b> Methodological problems of existing research, such as the application of unstandardized treatments in heterogeneous samples, has hampered clear conclusions about the extent and direction to which allelic variation of the serotonin transporter gene-linked polymorphic region (5- HTTLPR) is associated with a differential response to psychological treatment. The present study aimed to investigate the effects of the 5-HTTLPR genotype on treatment outcome under highly standardized environmental conditions. <b><i>Methods:</i></b> We treated 222 medication-free adults highly fearful of spiders, dental surgeries or blood, injuries and injections with a highly standardized exposure-based 1-session treatment and genotyped them for the 5-HTTLPR. Participants' subjective fear was assessed before, immediately after treatment and at 7 months of follow-up. <b><i>Results:</i></b> There were no differences between 5-HTTLPR genotypes in treatment outcome effects at the immediate posttreatment assessment. However, we observed a highly significant genotype × treatment effect (<i>p</i> = 0.004) at the 7-month follow-up. Fear levels of homozygous S allele carriers differed from those heterozygous (<i>p</i> = 0.026) and homozygous (<i>p</i> = 0.012) for the L allele. Compared to posttreatment assessment, LL allele carriers exhibited a further fear decrease at the follow-up assessment. In contrast, SS allele carriers displayed a strong return of fear. <b><i>Conclusions:</i></b> Results suggest that genetic variation of the serotonin transporter is associated with differential stability of inhibitory learning processes, potentially reflecting heightened susceptibility for context-related processes that facilitate a return of fear in S allele carriers. If replicated, results suggest the 5-HTTLPR might represent a biomarker for the long-term outcome of brief exposure-based fear treatments and might inform genotype-based selection of psychotherapeutic interventions.
DOI: 10.6084/m9.figshare.5903593.v1
title: Supplementary Material for: The Return of Fear: Variation of the Serotonin Transporter Gene Predicts Outcome of a Highly Standardized Exposure-Based One-Session Fear Treatment

description: <b><i>Background:</i></b> Methodological problems of existing research, such as the application of unstandardized treatments in heterogeneous samples, has hampered clear conclusions about the extent and direction to which allelic variation of the serotonin transporter gene-linked polymorphic region (5- HTTLPR) is associated with a differential response to psychological treatment. The present study aimed to investigate the effects of the 5-HTTLPR genotype on treatment outcome under highly standardized environmental conditions. <b><i>Methods:</i></b> We treated 222 medication-free adults highly fearful of spiders, dental surgeries or blood, injuries and injections with a highly standardized exposure-based 1-session treatment and genotyped them for the 5-HTTLPR. Participants' subjective fear was assessed before, immediately after treatment and at 7 months of follow-up. <b><i>Results:</i></b> There were no differences between 5-HTTLPR genotypes in treatment outcome effects at the immediate posttreatment assessment. However, we observed a highly significant genotype × treatment effect (<i>p</i> = 0.004) at the 7-month follow-up. Fear levels of homozygous S allele carriers differed from those heterozygous (<i>p</i> = 0.026) and homozygous (<i>p</i> = 0.012) for the L allele. Compared to posttreatment assessment, LL allele carriers exhibited a further fear decrease at the follow-up assessment. In contrast, SS allele carriers displayed a strong return of fear. <b><i>Conclusions:</i></b> Results suggest that genetic variation of the serotonin transporter is associated with differential stability of inhibitory learning processes, potentially reflecting heightened susceptibility for context-related processes that facilitate a return of fear in S allele carriers. If replicated, results suggest the 5-HTTLPR might represent a biomarker for the long-term outcome of brief exposure-based fear treatments and might inform genotype-based selection of psychotherapeutic interventions.
DOI: 10.6084/m9.figshare.5903560
title: Partition flie of 13 PCGs and 2 rRNAs by IQ-TREE

description: Partition flie of 13 PCGs and 2 rRNAs by IQ-TREE
DOI: 10.6084/m9.figshare.5903557
title: Alignment flie of 13 PCGs and 2 rRNAs by IQ-TREE

description: Alignment flie of 13 PCGs and 2 rRNAs by IQ-TREE
DOI: 10.6084/m9.figshare.5903560.v1
title: Partition flie of 13 PCGs and 2 rRNAs by IQ-TREE

description: Partition flie of 13 PCGs and 2 rRNAs by IQ-TREE
DOI: 10.6084/m9.figshare.5903557.v1
title: Alignment flie of 13 PCGs and 2 rRNAs by IQ-TREE

description: Alignment flie of 13 PCGs and 2 rRNAs by IQ-TREE
DOI: 10.6084/m9.figshare.5903554
title: Supplementary Material for: Hemostatic Efficacy and Safety of the Novel Medical Adhesive, MAR VIVO-107, in a Rabbit Liver Resection Model

description: <b><i>Background:</i></b> Topical hemostatic agents are useful when hepatic hemorrhage is difficult to control. The aim of this study was to evaluate the hemostatic efficacy and safety of a biodegradable polyurethane-based adhesive, MAR VIVO-107 (MAR), in comparison with a clinically used fibrin glue. <b><i>Methods:</i></b> Thirty female New Zealand white rabbits were randomly assigned to 3 study groups as follows: MAR (<i>n</i> = 10), fibrin glue (<i>n</i> = 10), and saline groups (<i>n</i> = 10). After standardized partial liver resection was performed, each agent was immediately applied to the wound area. Bleeding time until hemostasis and blood loss were recorded. After 7 days, body weight, hematology parameters, and serum levels of aspartate aminotransferase, alanine aminotransferase, and lactate dehydrogenase were measured. Simultaneously, the severity of intra-abdominal adhesion was evaluated. <b><i>Results:</i></b> The mean bleeding time in the MAR (38 ± 10 s) and fibrin glue groups (65 ± 17 s) was significantly shorter than that in the saline group (186 ± 12 s). Similarly, the mean blood loss in the MAR (9 ± 3 g) and fibrin glue groups (9 ± 3 g) was significantly less than that in the saline group (23 ± 4 g). No significant differences in bleeding time and blood loss were found between the MAR and fibrin glue groups. The postoperative survival rate was 100% in all the groups. Body weight as well as hematological and serum biochemical values on day 7 were within the small and physiological range when compared with the preoperative baseline values, and significant differences were not detected among the MAR, fibrin glue, and saline groups. The severities of adhesion were similar between the 3 groups. <b><i>Conclusion:</i></b> Our data demonstrated that MAR was not inferior to fibrin glue in terms of hemostatic efficacy and safety.
DOI: 10.6084/m9.figshare.5903554.v1
title: Supplementary Material for: Hemostatic Efficacy and Safety of the Novel Medical Adhesive, MAR VIVO-107, in a Rabbit Liver Resection Model

description: <b><i>Background:</i></b> Topical hemostatic agents are useful when hepatic hemorrhage is difficult to control. The aim of this study was to evaluate the hemostatic efficacy and safety of a biodegradable polyurethane-based adhesive, MAR VIVO-107 (MAR), in comparison with a clinically used fibrin glue. <b><i>Methods:</i></b> Thirty female New Zealand white rabbits were randomly assigned to 3 study groups as follows: MAR (<i>n</i> = 10), fibrin glue (<i>n</i> = 10), and saline groups (<i>n</i> = 10). After standardized partial liver resection was performed, each agent was immediately applied to the wound area. Bleeding time until hemostasis and blood loss were recorded. After 7 days, body weight, hematology parameters, and serum levels of aspartate aminotransferase, alanine aminotransferase, and lactate dehydrogenase were measured. Simultaneously, the severity of intra-abdominal adhesion was evaluated. <b><i>Results:</i></b> The mean bleeding time in the MAR (38 ± 10 s) and fibrin glue groups (65 ± 17 s) was significantly shorter than that in the saline group (186 ± 12 s). Similarly, the mean blood loss in the MAR (9 ± 3 g) and fibrin glue groups (9 ± 3 g) was significantly less than that in the saline group (23 ± 4 g). No significant differences in bleeding time and blood loss were found between the MAR and fibrin glue groups. The postoperative survival rate was 100% in all the groups. Body weight as well as hematological and serum biochemical values on day 7 were within the small and physiological range when compared with the preoperative baseline values, and significant differences were not detected among the MAR, fibrin glue, and saline groups. The severities of adhesion were similar between the 3 groups. <b><i>Conclusion:</i></b> Our data demonstrated that MAR was not inferior to fibrin glue in terms of hemostatic efficacy and safety.