cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.9249443
title: Table S2 from Adaptation to life on land at high O<sub>2</sub> via transition from ferredoxin-to NADH-dependent redox balance

description: BLAST output for the sequences without EPCs in Ku et al., 2015
DOI: 10.6084/m9.figshare.9249434
title: Quantile Risk Hedging Data

description: Data is used for research purpose only.
DOI: 10.6084/m9.figshare.9249425
title: The Role of Forum Membership Diversity on Institutional Externalities in Resource Governance Systems

description: In many resource governance systems, representatives of resource-related organizations gather in forums to discuss and develop solutions to policy problems. Forums often deal with interdependent policy problems, giving rise to institutional externalities: instances where decisions made in one forum either decrease (negative institutional externality) or increase (positive institutional externality) the rate by which current policy outputs in <i>other forums</i> resolve their prescribed policy problems. In this article we argue that forum-specific factors can impact the direction of such externalities. We theorize that forums with more diverse memberships in terms of both the issues that participants care about and types of organizations represented are better equipped to incorporate more holistic, ecosystem-based perspectives, which promote the generation of positive institutional externalities. Our study utilizes survey data collected from forum participants in the California Delta. Results from a series of cross-nested regressions demonstrate a positive association between forum diversity and positive externalities.
DOI: 10.6084/m9.figshare.9249425.v1
title: The Role of Forum Membership Diversity on Institutional Externalities in Resource Governance Systems

description: In many resource governance systems, representatives of resource-related organizations gather in forums to discuss and develop solutions to policy problems. Forums often deal with interdependent policy problems, giving rise to institutional externalities: instances where decisions made in one forum either decrease (negative institutional externality) or increase (positive institutional externality) the rate by which current policy outputs in <i>other forums</i> resolve their prescribed policy problems. In this article we argue that forum-specific factors can impact the direction of such externalities. We theorize that forums with more diverse memberships in terms of both the issues that participants care about and types of organizations represented are better equipped to incorporate more holistic, ecosystem-based perspectives, which promote the generation of positive institutional externalities. Our study utilizes survey data collected from forum participants in the California Delta. Results from a series of cross-nested regressions demonstrate a positive association between forum diversity and positive externalities.
DOI: 10.6084/m9.figshare.9249434.v2
title: Quantile Risk Hedging Data

description: Data is used for research purpose only.
DOI: 10.6084/m9.figshare.9249434.v1
title: Quantile Risk Hedging Data

description: Data is used for research purpose only.
DOI: 10.6084/m9.figshare.9249365
title: Cell death induced autophagy contributes to terminal differentiation of skin and skin appendages

description: In the adult mammalian skin, cells are constantly renewing, differentiating and moving upward, to finally die in a yet not fully understood manner. Here, we provide evidence that macroautophagy/autophagy has a dual role in the skin. In addition to its known catabolic protective role as an evolutionary conserved upstream regulator of lysosomal degradation, we show that autophagy induced cell death (CDA) occurs in epithelial lineage-derived organs, such as the inter-follicular epidermis, the sebaceous- and the Harderian gland. By utilizing GFP-LC3 transgenic and ATG7-deficient mice, we show that CDA is initiated during terminal differentiation at a stage when the cells have become highly resistant to apoptosis. In these transitional cells, the Golgi compartment expands, which accounts for the formation of primary lysosomes, and the nucleus starts to condense. During CDA a burst of autophagosome formation is observed, first the endoplasmic reticulum (ER) is phagocytosed followed by autophagy of the nucleus. By this selective form of cell death, most of the cytoplasmic organelles are degraded, but structural proteins remain intact. In the absence of autophagy, consequently, parts of the ER, ribosomes, and chromatin remain. A burst of autophagy was stochastically observed in single cells of the epidermis and collectively in larger areas of ductal cells, arguing for a coordinated induction. We conclude that autophagy is an integral part of cell death in keratinocyte lineage cells and participates in their terminal cell fate. <b>Abbreviations:</b> Atg7: autophagy related 7; BECN1: beclin 1; CDA: cell death-induced autophagy; Cre: Cre-recombinase; DAPI: 4′,6-diamidino-2-phenylindole; ER: endoplasmatic reticulum; GFP: green fluorescent protein; HaGl: haderian gland; IVL: involucrin; KRT14: keratin 14; LD: lipid droplet; LSM: laser scanning microscope; MAP1LC3/LC3: microtubule-associated protein 1 light chain 3; PN: perinuclear space; RB: residual body; rER: rough endoplasmatic reticulum; SB: sebum; SG-SC: stratum granulosum – stratum corneum; SGl: sebaceous gland; SQSTM1: sequestosome 1; TEM: transmission electron microscopy; TUNEL: terminal deoxynucleotidyl transferase dUTP nick end labelling.
DOI: 10.6084/m9.figshare.9249365.v2
title: Cell death induced autophagy contributes to terminal differentiation of skin and skin appendages

description: In the adult mammalian skin, cells are constantly renewing, differentiating and moving upward, to finally die in a yet not fully understood manner. Here, we provide evidence that macroautophagy/autophagy has a dual role in the skin. In addition to its known catabolic protective role as an evolutionary conserved upstream regulator of lysosomal degradation, we show that autophagy induced cell death (CDA) occurs in epithelial lineage-derived organs, such as the inter-follicular epidermis, the sebaceous- and the Harderian gland. By utilizing GFP-LC3 transgenic and ATG7-deficient mice, we show that CDA is initiated during terminal differentiation at a stage when the cells have become highly resistant to apoptosis. In these transitional cells, the Golgi compartment expands, which accounts for the formation of primary lysosomes, and the nucleus starts to condense. During CDA a burst of autophagosome formation is observed, first the endoplasmic reticulum (ER) is phagocytosed followed by autophagy of the nucleus. By this selective form of cell death, most of the cytoplasmic organelles are degraded, but structural proteins remain intact. In the absence of autophagy, consequently, parts of the ER, ribosomes, and chromatin remain. A burst of autophagy was stochastically observed in single cells of the epidermis and collectively in larger areas of ductal cells, arguing for a coordinated induction. We conclude that autophagy is an integral part of cell death in keratinocyte lineage cells and participates in their terminal cell fate. <b>Abbreviations:</b> Atg7: autophagy related 7; BECN1: beclin 1; CDA: cell death-induced autophagy; Cre: Cre-recombinase; DAPI: 4′,6-diamidino-2-phenylindole; ER: endoplasmatic reticulum; GFP: green fluorescent protein; HaGl: haderian gland; IVL: involucrin; KRT14: keratin 14; LD: lipid droplet; LSM: laser scanning microscope; MAP1LC3/LC3: microtubule-associated protein 1 light chain 3; PN: perinuclear space; RB: residual body; rER: rough endoplasmatic reticulum; SB: sebum; SG-SC: stratum granulosum – stratum corneum; SGl: sebaceous gland; SQSTM1: sequestosome 1; TEM: transmission electron microscopy; TUNEL: terminal deoxynucleotidyl transferase dUTP nick end labelling.
DOI: 10.6084/m9.figshare.9249365.v1
title: Cell death induced autophagy contributes to terminal differentiation of skin and skin appendages

description: In the adult mammalian skin, cells are constantly renewing, differentiating and moving upward, to finally die in a yet not fully understood manner. Here, we provide evidence that macroautophagy/autophagy has a dual role in the skin. In addition to its known catabolic protective role as an evolutionary conserved upstream regulator of lysosomal degradation, we show that autophagy induced cell death (CDA) occurs in epithelial lineage-derived organs, such as the inter-follicular epidermis, the sebaceous- and the Harderian gland. By utilizing GFP-LC3 transgenic and ATG7-deficient mice, we show that CDA is initiated during terminal differentiation at a stage when the cells have become highly resistant to apoptosis. In these transitional cells, the Golgi compartment expands, which accounts for the formation of primary lysosomes, and the nucleus starts to condense. During CDA a burst of autophagosome formation is observed, first the endoplasmic reticulum (ER) is phagocytosed followed by autophagy of the nucleus. By this selective form of cell death, most of the cytoplasmic organelles are degraded, but structural proteins remain intact. In the absence of autophagy, consequently, parts of the ER, ribosomes, and chromatin remain. A burst of autophagy was stochastically observed in single cells of the epidermis and collectively in larger areas of ductal cells, arguing for a coordinated induction. We conclude that autophagy is an integral part of cell death in keratinocyte lineage cells and participates in their terminal cell fate. <b>Abbreviations:</b> Atg7: autophagy related 7; BECN1: beclin 1; CDA: cell death-induced autophagy; Cre: Cre-recombinase; DAPI: 4′,6-diamidino-2-phenylindole; ER: endoplasmatic reticulum; GFP: green fluorescent protein; HaGl: haderian gland; IVL: involucrin; KRT14: keratin 14; LD: lipid droplet; LSM: laser scanning microscope; MAP1LC3/LC3: microtubule-associated protein 1 light chain 3; PN: perinuclear space; RB: residual body; rER: rough endoplasmatic reticulum; SB: sebum; SG-SC: stratum granulosum – stratum corneum; SGl: sebaceous gland; SQSTM1: sequestosome 1; TEM: transmission electron microscopy; TUNEL: terminal deoxynucleotidyl transferase dUTP nick end labelling.
DOI: 10.6084/m9.figshare.9249323
title: MATCHED SAMPLE.xlsx

description: Sample
DOI: 10.6084/m9.figshare.9249323.v1
title: MATCHED SAMPLE.xlsx

description: Sample
DOI: 10.6084/m9.figshare.9249311
title: Validation queries for the paper OKG-Soft: An Open Knowledge Graph with Machine Readable Scientific Software Metadata

description: Validation queries for the paper OKG-Soft: An Open Knowledge Graph with Machine Readable Scientific Software Metadata. The queries are shown in SPARQL along with the results obtained when they were executed. Note that since the execution of these queries the vocabularies and knowledge graph may have slightly changed and small changes may be needed to execute the query.<br>
DOI: 10.6084/m9.figshare.9249308
title: PVCVTRawECGData.zip

description: The 12-lead ECG data analysis is a reliable tool to ascertain the locations of premature ventricular contractions or ventricular tachycardia and determine the locations of subsequent catheter ablation procedure. The majority of idiopathic ventricular arrhythmia, outflow tract ventricular arrhythmia stem from either the right ventricular outflow tract or the left ventricular outflow tract. We created a new 12-lead ECG database that was created under the auspices of Chapman University and Ningbo First Hospital of Zhejiang University with the intention to provide high quality evidence revealing the distinction between idiopathic ventricular arrhythmia from right ventricular outflow tract to left ventricular outflow tract. The dataset contains 334 subjects who not only experienced idiopathic premature ventricular contractions or ventricular tachycardia but also had successfully undergone a catheter ablation procedure that validated the accurate origins of idiopathic ventricular arrhythmia.
DOI: 10.6084/m9.figshare.9249299
title: Raw matrix of cross-sectional geometry measures and biomechanical property values.

description: Raw data associated with the manuscript: Sex differences in the patterning of age-related bone loss in the human hallucal metatarsal in rural and urban populations<br>
DOI: 10.6084/m9.figshare.9249299.v1
title: Raw matrix of cross-sectional geometry measures and biomechanical property values.

description: Raw data associated with the manuscript: Sex differences in the patterning of age-related bone loss in the human hallucal metatarsal in rural and urban populations<br>
DOI: 10.6084/m9.figshare.9249305
title: PVCVTECGData After Noise Reduction

description: The 12-lead ECG data analysis is a reliable tool to ascertain the locations of premature ventricular contractions or ventricular tachycardia and determine the locations of subsequent catheter ablation procedure. The majority of idiopathic ventricular arrhythmia, outflow tract ventricular arrhythmia stem from either the right ventricular outflow tract or the left ventricular outflow tract. We created a new 12-lead ECG database that was created under the auspices of Chapman University and Ningbo First Hospital of Zhejiang University with the intention to provide high quality evidence revealing the distinction between idiopathic ventricular arrhythmia from right ventricular outflow tract to left ventricular outflow tract. The dataset contains 334 subjects who not only experienced idiopathic premature ventricular contractions or ventricular tachycardia but also had successfully undergone a catheter ablation procedure that validated the accurate origins of idiopathic ventricular arrhythmia.<br>
DOI: 10.6084/m9.figshare.9249173
title: 直方图.xlsx

description: data
DOI: 10.6084/m9.figshare.9249134
title: Quantification Figure 5 (GraphPad Prism file)

description: Figure 5 – Morphological analysis of human iPSC-derived activated astrocytes following 5 days TNF-α stimulation. (b) – Quantification of vimentin immunostaining; (c) – Quantification of cell area in vimentin-stained cells. (d) – Percentage of astrocyte polarization, which cells were classified according to increase of length/width ratio of vimentin-stained labeling. (e) - Quantification of GFAP immunostaining expressed in arbitrary units of immunofluorescence (A.U); (f) - Quantification of DAPI-stained nuclei areas expressed as percentage of micrometers. Data are presented as means ± SEM from 4 cell lines in experiments performed in triplicates. ***P &lt; 0.001. Unpaired Student´s t-test. Photomicrographs magnification: 200x. Calibration bar: 100 μm.
DOI: 10.6084/m9.figshare.9249131
title: Quantification Figure 2 (GraphPad Prism file)

description: Figure 2 – TNF-α-induced NF-kB nuclear translocation in human iPSC-derived astrocytes. Quantification of NF-kB immunoreactivity in both (b) – Nuclei and (c) – Whole cell area, which were expressed in arbitrary units of immunofluorescence (A.U.). (d) – The NF-kB translocation index (nuclei/whole cell area ratio). Data are presented as means ± SEM of experiments performed in triplicates from 3 cell lines. *P &lt; 0.05, different from vehicle; **P &lt; 0.05, different from vehicle and 1 ng/mL TNF-α. ***P &lt; 0.05, different from 10 ng/mL TNF-α. One-way ANOVA followed Tukey´s post hoc test. Magnification: 100 x. Calibration bar: 200 μm.
DOI: 10.6084/m9.figshare.9249131.v1
title: Quantification Figure 2 (GraphPad Prism file)

description: Figure 2 – TNF-α-induced NF-kB nuclear translocation in human iPSC-derived astrocytes. Quantification of NF-kB immunoreactivity in both (b) – Nuclei and (c) – Whole cell area, which were expressed in arbitrary units of immunofluorescence (A.U.). (d) – The NF-kB translocation index (nuclei/whole cell area ratio). Data are presented as means ± SEM of experiments performed in triplicates from 3 cell lines. *P &lt; 0.05, different from vehicle; **P &lt; 0.05, different from vehicle and 1 ng/mL TNF-α. ***P &lt; 0.05, different from 10 ng/mL TNF-α. One-way ANOVA followed Tukey´s post hoc test. Magnification: 100 x. Calibration bar: 200 μm.
DOI: 10.6084/m9.figshare.9249134.v1
title: Quantification Figure 5 (GraphPad Prism file)

description: Figure 5 – Morphological analysis of human iPSC-derived activated astrocytes following 5 days TNF-α stimulation. (b) – Quantification of vimentin immunostaining; (c) – Quantification of cell area in vimentin-stained cells. (d) – Percentage of astrocyte polarization, which cells were classified according to increase of length/width ratio of vimentin-stained labeling. (e) - Quantification of GFAP immunostaining expressed in arbitrary units of immunofluorescence (A.U); (f) - Quantification of DAPI-stained nuclei areas expressed as percentage of micrometers. Data are presented as means ± SEM from 4 cell lines in experiments performed in triplicates. ***P &lt; 0.001. Unpaired Student´s t-test. Photomicrographs magnification: 200x. Calibration bar: 100 μm.
DOI: 10.6084/m9.figshare.9249122
title: Ecopapers scrape 2019

description: A WoS scrape of ecopaper performance over time.
DOI: 10.6084/m9.figshare.9249128
title: Untitled Item

description: chromatogram of standard of C4-C24 fatty acid
DOI: 10.6084/m9.figshare.9249140.v1
title: Quantification Figure 4 (GraphPad Prism file)

description: Figure 4 – Cytokines expression in cell extracts from human iPSC-derived astrocytes. (a) – Interleukin-6; (b) – Interleukin-1 beta and (c) – TNF-α expression was assessed 24 h after exposing cells to vehicle or 10 ng/mL TNF-α. Data are presented as means ± SEM of fold change for (a) and (b) and Ct (c) since the basal levels of TNF-α were below the limit of quantification in non-stimulated cells. Experiments were performed in triplicates from 4 cell lines. *P &lt; 0.05; N.D. non detected. Unpaired Student´s t-test.
DOI: 10.6084/m9.figshare.9249128.v1
title: Untitled Item

description: chromatogram of standard of C4-C24 fatty acid
DOI: 10.6084/m9.figshare.9249122.v1
title: Ecopapers scrape 2019

description: A WoS scrape of ecopaper performance over time.
DOI: 10.6084/m9.figshare.9249074
title: Neural Network - Observation dataset

description: A dataset with observations to train a neural network.
DOI: 10.6084/m9.figshare.9249032
title: Quantification Figure 2 (GraphPad Prism file)

description: TNF-α-induced NF-kB nuclear translocation in human iPSC-derived astrocytes.(a) - Photomicrographs of NF-kB immunostaining 1 h after exposing cells to vehicle or five different concentrations of TNF-α. Quantification of NF-kB immunoreactivity in both (b) – Nuclei and (c) – Whole cell area, which were expressed in arbitrary units of immunofluorescence (A.U.). (d) – The NF-kB translocation index (nuclei/whole cell area ratio). Data are presented as means ± SEM of experiments performed in triplicates from 3 cell lines. *P &lt; 0.05, different from vehicle; **P &lt; 0.05, different from vehicle and 1 ng/mL TNF-α. ***P &lt; 0.05, different from 10 ng/mL TNF-α. One-way ANOVA followed Tukey´s post hoc test. Magnification: 100 x. Calibration bar: 200 μm.
DOI: 10.6084/m9.figshare.9249029
title: Quantification Figure 5 (GraphPad Prism file)

description: Morphological analysis of human iPSC-derived activated astrocytes following 5 days TNF-α stimulation.(a) - Photomicrographs of human iPSC-derived astrocytes immunostained for vimentin (red), GFAP (green) and DAPI (blue); (b) – Quantification of vimentin immunostaining; (c) – Quantification of cell area in vimentin-stained cells. (d) – Percentage of astrocyte polarization, which cells were classified according to increase of length/width ratio of vimentin-stained labeling. (e) - Quantification of GFAP immunostaining expressed in arbitrary units of immunofluorescence (A.U); (f) - Quantification of DAPI-stained nuclei areas expressed as percentage of micrometers. Data are presented as means ± SEM from 4 cell lines in experiments performed in triplicates. ***P &lt; 0.001. Unpaired Student´s t-test. Photomicrographs magnification: 200x. Calibration bar: 100 μm.
DOI: 10.6084/m9.figshare.9249026
title: Quantification Figure 4 (GraphPad Prism file)

description: (a) – Interleukin-6; (b) – Interleukin-1 beta and (c) – TNF-α expression was assessed 24 h after exposing cells to vehicle or 10 ng/mL TNF-α. Data are presented as means ± SEM of fold change for (a) and (b) and Ct (c) since the basal levels of TNF-α were below the limit of quantification in non-stimulated cells. Experiments were performed in triplicates from 4 cell lines. *P &lt; 0.05; N.D. non detected. Unpaired Student´s t-test.
DOI: 10.6084/m9.figshare.9249029.v2
title: Quantification Figure 5 (GraphPad Prism file)

description: Morphological analysis of human iPSC-derived activated astrocytes following 5 days TNF-α stimulation.(a) - Photomicrographs of human iPSC-derived astrocytes immunostained for vimentin (red), GFAP (green) and DAPI (blue); (b) – Quantification of vimentin immunostaining; (c) – Quantification of cell area in vimentin-stained cells. (d) – Percentage of astrocyte polarization, which cells were classified according to increase of length/width ratio of vimentin-stained labeling. (e) - Quantification of GFAP immunostaining expressed in arbitrary units of immunofluorescence (A.U); (f) - Quantification of DAPI-stained nuclei areas expressed as percentage of micrometers. Data are presented as means ± SEM from 4 cell lines in experiments performed in triplicates. ***P &lt; 0.001. Unpaired Student´s t-test. Photomicrographs magnification: 200x. Calibration bar: 100 μm.
DOI: 10.6084/m9.figshare.9249032.v2
title: Quantification Figure 2 (GraphPad Prism file)

description: TNF-α-induced NF-kB nuclear translocation in human iPSC-derived astrocytes.(a) - Photomicrographs of NF-kB immunostaining 1 h after exposing cells to vehicle or five different concentrations of TNF-α. Quantification of NF-kB immunoreactivity in both (b) – Nuclei and (c) – Whole cell area, which were expressed in arbitrary units of immunofluorescence (A.U.). (d) – The NF-kB translocation index (nuclei/whole cell area ratio). Data are presented as means ± SEM of experiments performed in triplicates from 3 cell lines. *P &lt; 0.05, different from vehicle; **P &lt; 0.05, different from vehicle and 1 ng/mL TNF-α. ***P &lt; 0.05, different from 10 ng/mL TNF-α. One-way ANOVA followed Tukey´s post hoc test. Magnification: 100 x. Calibration bar: 200 μm.
DOI: 10.6084/m9.figshare.9249032.v1
title: Figure 2

description: TNF-α-induced NF-kB nuclear translocation in human iPSC-derived astrocytes.(a) - Photomicrographs of NF-kB immunostaining 1 h after exposing cells to vehicle or five different concentrations of TNF-α. Quantification of NF-kB immunoreactivity in both (b) – Nuclei and (c) – Whole cell area, which were expressed in arbitrary units of immunofluorescence (A.U.). (d) – The NF-kB translocation index (nuclei/whole cell area ratio). Data are presented as means ± SEM of experiments performed in triplicates from 3 cell lines. *P &lt; 0.05, different from vehicle; **P &lt; 0.05, different from vehicle and 1 ng/mL TNF-α. ***P &lt; 0.05, different from 10 ng/mL TNF-α. One-way ANOVA followed Tukey´s post hoc test. Magnification: 100 x. Calibration bar: 200 μm.
DOI: 10.6084/m9.figshare.9249029.v1
title: Figure 5

description: Morphological analysis of human iPSC-derived activated astrocytes following 5 days TNF-α stimulation.(a) - Photomicrographs of human iPSC-derived astrocytes immunostained for vimentin (red), GFAP (green) and DAPI (blue); (b) – Quantification of vimentin immunostaining; (c) – Quantification of cell area in vimentin-stained cells. (d) – Percentage of astrocyte polarization, which cells were classified according to increase of length/width ratio of vimentin-stained labeling. (e) - Quantification of GFAP immunostaining expressed in arbitrary units of immunofluorescence (A.U); (f) - Quantification of DAPI-stained nuclei areas expressed as percentage of micrometers. Data are presented as means ± SEM from 4 cell lines in experiments performed in triplicates. ***P &lt; 0.001. Unpaired Student´s t-test. Photomicrographs magnification: 200x. Calibration bar: 100 μm.