cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.9730781
title: consensus Tree 10kTrees Primates Version3 nex from Maternal investment, life histories and the evolution of brain structure in primates

description: Life history is a robust correlate of relative brain size: larger-brained mammals and birds have slower life histories and longer lifespans than smaller-brained species. The Cognitive buffer hypothesis (CBH) proposes an adaptive explanation for this relationship: large brains may permit greater behavioural flexibility and thereby buffer the animal from unpredictable environmental challenges, allowing for reduced mortality and increased lifespan. By contrast, the Developmental costs hypothesis (DCH) suggests that life-history correlates of brain size reflect the extension of maturational processes needed to accommodate the evolution of large brains, predicting correlations with pre-adult life-history phases. Here, we test novel predictions of the hypotheses in primates applied to the neocortex and cerebellum, two major brain structures with distinct developmental trajectories. While neocortical growth is allocated primarily to prenatal development, the cerebellum exhibits relatively substantial post-natal growth. Consistent with the DCH, neocortical expansion is related primarily to extended gestation while cerebellar expansion to extended post-natal development, particularly the juvenile period. Contrary to the CBH, adult lifespan explains relatively little variance in the whole brain or neocortex volume once pre-adult life-history phases are accounted for. Only the cerebellum shows a relationship with lifespan after accounting for developmental periods. Our results substantiate and elaborate on the role of maternal investment and offspring development in brain evolution, suggest that brain components can evolve partly independently through modifications of distinct developmental phases and imply that environmental input during post-natal maturation may be particularly crucial for the development of cerebellar function. They also suggest that relatively extended maturation times provide a developmental mechanism for the marked expansion of the cerebellum in the apes.
DOI: 10.6084/m9.figshare.9730784
title: Anage data from Maternal investment, life histories and the evolution of brain structure in primates

description: Life history is a robust correlate of relative brain size: larger-brained mammals and birds have slower life histories and longer lifespans than smaller-brained species. The Cognitive buffer hypothesis (CBH) proposes an adaptive explanation for this relationship: large brains may permit greater behavioural flexibility and thereby buffer the animal from unpredictable environmental challenges, allowing for reduced mortality and increased lifespan. By contrast, the Developmental costs hypothesis (DCH) suggests that life-history correlates of brain size reflect the extension of maturational processes needed to accommodate the evolution of large brains, predicting correlations with pre-adult life-history phases. Here, we test novel predictions of the hypotheses in primates applied to the neocortex and cerebellum, two major brain structures with distinct developmental trajectories. While neocortical growth is allocated primarily to prenatal development, the cerebellum exhibits relatively substantial post-natal growth. Consistent with the DCH, neocortical expansion is related primarily to extended gestation while cerebellar expansion to extended post-natal development, particularly the juvenile period. Contrary to the CBH, adult lifespan explains relatively little variance in the whole brain or neocortex volume once pre-adult life-history phases are accounted for. Only the cerebellum shows a relationship with lifespan after accounting for developmental periods. Our results substantiate and elaborate on the role of maternal investment and offspring development in brain evolution, suggest that brain components can evolve partly independently through modifications of distinct developmental phases and imply that environmental input during post-natal maturation may be particularly crucial for the development of cerebellar function. They also suggest that relatively extended maturation times provide a developmental mechanism for the marked expansion of the cerebellum in the apes.
DOI: 10.6084/m9.figshare.9730784.v1
title: Anage data from Maternal investment, life histories and the evolution of brain structure in primates

description: Life history is a robust correlate of relative brain size: larger-brained mammals and birds have slower life histories and longer lifespans than smaller-brained species. The Cognitive buffer hypothesis (CBH) proposes an adaptive explanation for this relationship: large brains may permit greater behavioural flexibility and thereby buffer the animal from unpredictable environmental challenges, allowing for reduced mortality and increased lifespan. By contrast, the Developmental costs hypothesis (DCH) suggests that life-history correlates of brain size reflect the extension of maturational processes needed to accommodate the evolution of large brains, predicting correlations with pre-adult life-history phases. Here, we test novel predictions of the hypotheses in primates applied to the neocortex and cerebellum, two major brain structures with distinct developmental trajectories. While neocortical growth is allocated primarily to prenatal development, the cerebellum exhibits relatively substantial post-natal growth. Consistent with the DCH, neocortical expansion is related primarily to extended gestation while cerebellar expansion to extended post-natal development, particularly the juvenile period. Contrary to the CBH, adult lifespan explains relatively little variance in the whole brain or neocortex volume once pre-adult life-history phases are accounted for. Only the cerebellum shows a relationship with lifespan after accounting for developmental periods. Our results substantiate and elaborate on the role of maternal investment and offspring development in brain evolution, suggest that brain components can evolve partly independently through modifications of distinct developmental phases and imply that environmental input during post-natal maturation may be particularly crucial for the development of cerebellar function. They also suggest that relatively extended maturation times provide a developmental mechanism for the marked expansion of the cerebellum in the apes.
DOI: 10.6084/m9.figshare.9730745
title: MATLAB Function from Multi-objective control in human walking: insight gained through simultaneous degradation of energetic and motor regulation systems

description: Minimization of metabolic energy is considered a fundamental principle of human locomotion, as demonstrated by an alignment between the preferred walking speed (PWS) and the speed incurring the lowest metabolic cost of transport. We aimed to (i) simultaneously disrupt metabolic cost and an alternate acute task requirement, namely speed error regulation, and (ii) assess whether the PWS could be explained on the basis of either optimality criterion in this new performance and energetic landscape. Healthy adults (<i>N </i>= 21) walked on an instrumented treadmill under normal conditions and, while negotiating a continuous gait perturbation, imposed leg-length asymmetry. Oxygen consumption, motion capture data and ground reaction forces were continuously recorded for each condition at speeds ranging from 0.6 to 1.8 m s<sup>−1</sup>, including the PWS. Both metabolic and speed regulation measures were disrupted by the perturbation (<i>p</i>
DOI: 10.6084/m9.figshare.9730745.v1
title: MATLAB Function from Multi-objective control in human walking: insight gained through simultaneous degradation of energetic and motor regulation systems

description: Minimization of metabolic energy is considered a fundamental principle of human locomotion, as demonstrated by an alignment between the preferred walking speed (PWS) and the speed incurring the lowest metabolic cost of transport. We aimed to (i) simultaneously disrupt metabolic cost and an alternate acute task requirement, namely speed error regulation, and (ii) assess whether the PWS could be explained on the basis of either optimality criterion in this new performance and energetic landscape. Healthy adults (<i>N </i>= 21) walked on an instrumented treadmill under normal conditions and, while negotiating a continuous gait perturbation, imposed leg-length asymmetry. Oxygen consumption, motion capture data and ground reaction forces were continuously recorded for each condition at speeds ranging from 0.6 to 1.8 m s<sup>−1</sup>, including the PWS. Both metabolic and speed regulation measures were disrupted by the perturbation (<i>p</i>
DOI: 10.6084/m9.figshare.9730706
title: Best-hit placement tree from A global metabarcoding analysis expands molecular diversity of Platyhelminthes and reveals novel early-branching clades

description: It is the tree of the figure 1C and 2A. It shows the position with the highest likelihood-weight score of the short queries in the reference tree.
DOI: 10.6084/m9.figshare.9730706.v1
title: Best-hit placement tree from A global metabarcoding analysis expands molecular diversity of Platyhelminthes and reveals novel early-branching clades

description: It is the tree of the figure 1C and 2A. It shows the position with the highest likelihood-weight score of the short queries in the reference tree.
DOI: 10.6084/m9.figshare.9730625
title: Supplementary Material for: Elevated Triglycerides (≥150 mg/dL) and High Triglycerides (200–499 mg/dL) Are Significant Predictors of Hospitalization for New-Onset Kidney Disease: A Real-World Analysis of High-Risk Statin-Treated Patients

description: <b><i>Background:</i></b> Dyslipidemia in kidney disease (KD) involves increased levels of triglycerides (TG) and TG-rich lipoproteins, with only minor changes in low-density lipoprotein cholesterol. The increasing prevalence of diabetic KD and the shared atherogenic lipid profile between KD and diabetes underscore the importance of understanding dyslipidemia in these patients. Previous studies suggest an association between elevated TG and new-onset KD. Additional data are needed to better define the relationship between hypertriglyceridemia and new-onset KD. <b><i>Objective:</i></b> To evaluate the real-world impact of elevated and high TG on risk of KD in high-risk statin-treated patients. <b><i>Methods:</i></b> This retrospective administrative claims analysis of the Optum Research Database included statin-treated patients (age ≥45 years) with diabetes and/or atherosclerotic cardiovascular disease who were followed for ≥6 months. Cohorts included patients with elevated TG (≥150 mg/dL; <i>n</i> = 27,471) or high TG (200–499 mg/dL; subgroup of elevated TG cohort; <i>n</i> = 13,411), and a comparator cohort (TG &lt;150 mg/dL and high-density lipoprotein cholesterol &gt;40 mg/dL; <i>n</i> = 32,506). The probability of hospitalization for new-onset KD was calculated post hoc from multivariate analyses controlled for patient characteristics and comorbidities using a Cox proportional hazards model. <b><i>Results:</i></b> The rate of hospitalization for new-onset KD was 31% higher in the elevated-TG cohort (hazard ratio [HR], 1.311; 95% confidence interval [CI], 1.228–1.401; <i>p</i> &lt; 0.001) and 45% higher in the high-TG cohort (HR, 1.451; 95% CI, 1.339–1.572; <i>p</i> &lt; 0.001) compared with the respective comparator cohorts. <b><i>Conclusions:</i></b> In a real-world analysis of statin-treated patients with high cardiovascular risk, both elevated TG (≥150 mg/dL) and high TG (200–499 mg/dL) were significant predictors of hospitalization for new-onset KD, identifying hypertriglyceridemia as a potential KD risk factor.
DOI: 10.6084/m9.figshare.9730604
title: Different regulations of cell-type transcription by UV-B in multicellular green alga <i>Volvox carteri</i>

description: There is a scarcity of research reports on the effect of ultraviolet (UV)-B radiation on genome-wide transcriptional regulation in the multicellular green microalga including <i>Volvox carteri</i> (<i>V. carteri</i>). This microalga possesses only two cell types including mortal and motile somatic cells, as well as immortal and immotile reproductive cells. Therefore, the present study evaluated the effect of low-dose UV-B radiation on the cell-type-specific gene expression pattern of reproductive and somatic cells in an asexual life cycle of <i>V. carteri</i> using RNA sequence method. To this end, the separated reproductive and somatic cells were treated for 1 hour at an intensity of 0.056 mW/cm<sup>−2</sup> UV-B radiation. Then, a transcriptome analysis was conducted between the UV-B and white light treated groups in either of the cell types. Based on differential gene expression analyses, no differentially expressed genes were found in reproductive cells under the treatment as compared to the control group. This type of cell maintained its steady state. However, treating the somatic cells with UV-B radiation led to at least 126 differentially expressed genes compared to the untreated control group. In addition, the results of a direct comparison demonstrated a restricted and wide response to UV-B radiation in somatic cells as compared to reproductive cells. Based on the results, UV-B radiation could be involved in cell-type-specific regulation of biological pathways.
DOI: 10.6084/m9.figshare.9730604.v1
title: Different regulations of cell-type transcription by UV-B in multicellular green alga <i>Volvox carteri</i>

description: There is a scarcity of research reports on the effect of ultraviolet (UV)-B radiation on genome-wide transcriptional regulation in the multicellular green microalga including <i>Volvox carteri</i> (<i>V. carteri</i>). This microalga possesses only two cell types including mortal and motile somatic cells, as well as immortal and immotile reproductive cells. Therefore, the present study evaluated the effect of low-dose UV-B radiation on the cell-type-specific gene expression pattern of reproductive and somatic cells in an asexual life cycle of <i>V. carteri</i> using RNA sequence method. To this end, the separated reproductive and somatic cells were treated for 1 hour at an intensity of 0.056 mW/cm<sup>−2</sup> UV-B radiation. Then, a transcriptome analysis was conducted between the UV-B and white light treated groups in either of the cell types. Based on differential gene expression analyses, no differentially expressed genes were found in reproductive cells under the treatment as compared to the control group. This type of cell maintained its steady state. However, treating the somatic cells with UV-B radiation led to at least 126 differentially expressed genes compared to the untreated control group. In addition, the results of a direct comparison demonstrated a restricted and wide response to UV-B radiation in somatic cells as compared to reproductive cells. Based on the results, UV-B radiation could be involved in cell-type-specific regulation of biological pathways.
DOI: 10.6084/m9.figshare.9730565
title: Isolation and characterization of the insecticidal, two-domain toxin LaIT3 from the <i>Liocheles australasiae</i> scorpion venom

description: A novel insecticidal peptide (LaIT3) was isolated from the <i>Liocheles australasiae</i> venom. The primary structure of LaIT3 was determined by a combination of Edman degradation and MS/MS de novo sequencing analysis. Discrimination between Leu and Ile in MS/MS analysis was achieved based on the difference in side chain fragmentation assisted by chemical derivatization. LaIT3 was determined to be an 84-residue peptide with three intrachain disulfide bonds. The sequence similarity search revealed that LaIT3 belongs to the scorpine-like peptides consisting of two structural domains: an N-terminal α-helical domain and a C-terminal cystine-stabilized domain. As observed for most of the scorpine-like peptides, LaIT3 showed significant antibacterial activity against <i>Escherichia coli</i>, which is likely to be caused by its membrane-disrupting property. We isolated the insecticidal toxin LaIT3 from the <i>Liocheles australasiae</i> scorpion venom and determined its structure using Edman and MS/MS analyses.
DOI: 10.6084/m9.figshare.9730565.v1
title: Isolation and characterization of the insecticidal, two-domain toxin LaIT3 from the <i>Liocheles australasiae</i> scorpion venom

description: A novel insecticidal peptide (LaIT3) was isolated from the <i>Liocheles australasiae</i> venom. The primary structure of LaIT3 was determined by a combination of Edman degradation and MS/MS de novo sequencing analysis. Discrimination between Leu and Ile in MS/MS analysis was achieved based on the difference in side chain fragmentation assisted by chemical derivatization. LaIT3 was determined to be an 84-residue peptide with three intrachain disulfide bonds. The sequence similarity search revealed that LaIT3 belongs to the scorpine-like peptides consisting of two structural domains: an N-terminal α-helical domain and a C-terminal cystine-stabilized domain. As observed for most of the scorpine-like peptides, LaIT3 showed significant antibacterial activity against <i>Escherichia coli</i>, which is likely to be caused by its membrane-disrupting property. We isolated the insecticidal toxin LaIT3 from the <i>Liocheles australasiae</i> scorpion venom and determined its structure using Edman and MS/MS analyses.
DOI: 10.26180/5d63730aa71a3
title: Predictive Abilities of Speculators in Energy Markets: Data

description: Data on commitments of traders used in the study. <br>
DOI: 10.6084/m9.figshare.9730334
title: submission to JAMES_data repository

description: This is the data repository for the manuscript: " Implementation of the Unified Representation of Moist Convection in the Gray Zone CWBGFS", submitted to Journal of Advances in Modeling Earth Systems.
DOI: 10.6084/m9.figshare.9730334.v1
title: submission to JAMES_data repository

description: This is the data repository for the manuscript: " Implementation of the Unified Representation of Moist Convection in the Gray Zone CWBGFS", submitted to Journal of Advances in Modeling Earth Systems.
DOI: 10.6084/m9.figshare.9730304
title: Low proportions of folic acid deficiency after introduction of mandatory folic acid fortification in remote areas of northern Queensland, Australia: a secondary health data analysis

description: <b>Background:</b> Australia implemented mandatory folic acid fortification of bread-making flour in 2009. <b>Objective:</b> To assess the impact of folic acid fortification in remote vs. regional urban areas and Indigenous vs. non-Indigenous populations in northern Queensland. <b>Methods:</b> Routinely collected data on folic acid measurements in remote areas and two regional urban centres in northern Queensland between 2004 and 2015 were analysed (<i>n</i> = 13,929) dichotomously (folic deficient vs. non-deficient). <b>Results:</b> Overall prevalence of folic acid deficiency was 3.2% (235/7282) in urban centres compared with 7.2% (480/6647) in remote areas (<i>p</i> p n = 481) in 2004–2008 to 1.5% (<i>n</i> = 126) in 2010–2015 (<i>p</i> p <b>Conclusions:</b> Substantial declines of folic acid deficiency to low and comparable proportions in former high-risk populations indicate that mandatory folic acid fortification of flour has had a population-wide benefit in northern Queensland.
DOI: 10.6084/m9.figshare.9730304.v1
title: Low proportions of folic acid deficiency after introduction of mandatory folic acid fortification in remote areas of northern Queensland, Australia: a secondary health data analysis

description: <b>Background:</b> Australia implemented mandatory folic acid fortification of bread-making flour in 2009. <b>Objective:</b> To assess the impact of folic acid fortification in remote vs. regional urban areas and Indigenous vs. non-Indigenous populations in northern Queensland. <b>Methods:</b> Routinely collected data on folic acid measurements in remote areas and two regional urban centres in northern Queensland between 2004 and 2015 were analysed (<i>n</i> = 13,929) dichotomously (folic deficient vs. non-deficient). <b>Results:</b> Overall prevalence of folic acid deficiency was 3.2% (235/7282) in urban centres compared with 7.2% (480/6647) in remote areas (<i>p</i> p n = 481) in 2004–2008 to 1.5% (<i>n</i> = 126) in 2010–2015 (<i>p</i> p <b>Conclusions:</b> Substantial declines of folic acid deficiency to low and comparable proportions in former high-risk populations indicate that mandatory folic acid fortification of flour has had a population-wide benefit in northern Queensland.
DOI: 10.6084/m9.figshare.9730253
title: IMC EPOC

description: BASE DATA COPD
DOI: 10.6084/m9.figshare.9730244
title: Human gut volume data - J Uy

description: These were used to identify the scaling relationships between the intestines (gut) and the pelvis in recent modern humans. Values were taken from CT scans.
DOI: 10.6084/m9.figshare.9730253.v1
title: IMC EPOC

description: BASE DATA COPD
DOI: 10.6084/m9.figshare.9730217
title: SuppleMethod

description: Supplement method
DOI: 10.6084/m9.figshare.9730217.v1
title: SuppleMethod

description: Supplement method
DOI: 10.6084/m9.figshare.9730172
title: 47 cases with probable MHRA

description: 47 cases from US FDA MAUDE database involving death, cardiotocography, and probable maternal heart rate artefact.
DOI: 10.6084/m9.figshare.9730175
title: 29 cases with recommendations relating to MHRA

description: 29 cases from US FDA MAUDE database involving event type death, cardiotocography, and recommendations from manufacturers regarding maternal heart rate artefact.
DOI: 10.6084/m9.figshare.9730178
title: 14 cases of neonatal death or intrapartum stillbirth with probable MHRA

description: 14 cases of neonatal death or intrapartum stillbirth with probable MHRA from DA MAUDE database.
DOI: 10.6084/m9.figshare.9730157
title: Hydrogeochemical data of the North Coast of Mombasa, Kenya in March, June and September 2016

description: These data are an essential component of an African Union funded research project at the Pan African University-Institute for Basic Sciences Technology and Innovation hosted by the Jomo Kenyatta University of Agriculture & Technology, Kenya. Project Title: Groundwater flow and quality of coastal aquifers: Case study of Mombasa North Coast. The data include; * The GPS coordinate location of wells/boreholes * The Height of groundwater above mean sea level * Water quality parameters
DOI: 10.6084/m9.figshare.9730169
title: Full list of 117 cases of CTG-associated fetal or neonatal deaths

description: 117 cases from US FDA MAUDE database involving cardiotocography devices and event type death.
DOI: 10.6084/m9.figshare.9730136
title: data_figshare.xlsx

description: Data on volumes and cell count<br>
DOI: 10.6084/m9.figshare.9730163
title: Median of temperature and precipitation

description: Median of Temperature and precipitation change in 2071-2100 compared to 1971-2000 from a RCP2.6 and RCP8.5 Ensemble for Germany<br>
DOI: 10.6084/m9.figshare.9730136.v1
title: data_figshare.xlsx

description: Data on volumes and cell count<br>