cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.5255/ukda-sn-856867
title: The Second Most Important Pitch: How Digital Start-Ups Must Navigate the Endorsement Economy To Scale, 2018-2022

description: Our research uncovered an evaluation hurdle that plays a major, but unacknowledged, role in the growth and scaling of new digital start-ups. Much has been written about the new venture's first pitch to investors. For nascent digital enterprises, however, we identified a vital subsequent step where they must make a further pitch to industry analysts, theorised as the "second most important pitch". These firms, like Gartner, IDC, Forrester, etc., advise technology adopters on what new products are worth buying.

Yet, as our research revealed, many start-ups struggle with this second pitch. Our research found that ventures pitched something that had worked well previously with the investor without realising these pitches were very different. Indeed, many industry analysts we interviewed told us they were extremely keen to learn about new ventures' innovative products. Still, the ventures did not know how to talk to them and would waste their time.

This is because the analyst pitches differ from the investor pitch in several ways. For instance, if the venture wants to maintain analyst interest, it must brief them every few months. New companies are competing alongside other promising companies worldwide for the scarce attention of analysts. Those who interact more frequently with analysts - and keep them updated - stay fresh in the analyst's mind when they are compiling rankings, writing reports, and talking to technology buyers.

Moreover, whereas in the investor pitch, it is said that the potential funder is "betting on the jockey, not on the horse'", second pitches are different. The industry analyst is much more interested in the products offered. Successful companies told us it was also necessary to make the analysts passionate about their products so that they would champion them with others in the industry.

Our study found that making it onto an industry analyst ranking or becoming a "Gartner Cool Vendor" was only part of what could be gained from these pitches. The industry analyst might also talk up the venture with clients and others, advocate for it during client meetings, and give spontaneous feedback to help it foreground its more innovative attributes.

Our research theorises this second pitch as a new kind of pitch: a "valorising pitch". Scholars have identified several different kinds of pitch types to date. Still, none directly reflect the dynamics and audience identified here - of the valorising pitch - which we define as a device a digital start-up uses to enrol an industry analyst to help build market presence. Our research highlights how ventures would engage the industry analyst to overcome the damaging aspects of being an unknown quantity in the market. Valorisation appeared as powerful as other influences that stem from the formal evaluation system, such as industry analyst rankings, and ventures that proactively leveraged this valorisation appeared more likely to engage potential customers and other resource providers.
DOI: 10.6084/m9.figshare.9777245.v1
title: Exome sequencing of Saudi Arabian patients with ADPKD

description: <b>Purpose:</b> Autosomal dominant polycystic kidney disease (ADPKD) is characterized by progressive development of kidney cysts and enlargement and dysfunction of the kidneys. The Consortium of Radiologic Imaging Studies of the Polycystic Kidney Disease (CRISP) cohort revealed that 89.1% had either a <i>PKD1</i> or <i>PKD2</i> mutation. Of the CRISP patients with a genetic cause detected, mutations in <i>PKD1</i> accounted for 85%, while mutations in the <i>PKD2</i> accounted for the remaining 15%. Here, we report exome sequencing of 16 Saudi patients diagnosed with ADPKD and 16 ethnically matched controls. <b>Methods:</b> Exome sequencing was performed using combinatorial probe-anchor synthesis and improved DNA Nanoballs technology on BGISEQ-500 sequencers (BGI, China) using the BGI Exome V4 (59 Mb) Kit. Identified variants were validated with Sanger sequencing. <b>Results:</b> With the exception of GC-rich exon 1, we obtained excellent coverage of <i>PKD1</i> (mean read depth = 88) including both duplicated and non-duplicated regions. Of nine patients with typical ADPKD presentations (bilateral symmetrical kidney involvement, positive family history, concordant imaging, and kidney function), four had protein truncating <i>PKD1</i> mutations, one had a <i>PKD1</i> missense mutation, and one had a <i>PKD2</i> mutation. These variants have not been previously observed in the Saudi population. In seven clinically diagnosed ADPKD cases but with atypical features, no <i>PKD1</i> or <i>PKD2</i> mutations were identified, but rare predicted pathogenic heterozygous variants were found in cystogenic candidate genes including <i>PKHD1, PKD1L3, EGF, CFTR</i>, and <i>TSC2</i>. <b>Conclusions:</b> Mutations in PKD1 and PKD2 are the most common cause of ADPKD in Saudi patients with typical ADPKD. <b>Abbreviations:</b> ADPKD: Autosomal dominant polycystic kidney disease; <i>CFTR</i>: Cystic fibrosis transmembrane conductance regulator; <i>EGF</i>: Epidermal growth factor; MCIC: Mayo Clinic Imaging Classification; PKD: Polycystic kidney disease; <i>TSC2</i>: Tuberous sclerosis complex 2
DOI: 10.6084/m9.figshare.24457309
title: Open Research_field investigation data.zip

description: Measurement data ( wind friction velocity, albedo and reflectance) from 48 field investigation sites in Inner Mongolia Autonomous Region, China, April-June 2022.
DOI: 10.6084/m9.figshare.21835120.v1
title: Optimization of a cationic liposomal gene delivery system and study of its endocytic pathway

description: Abstract A cationic liposomal gene delivery system comprising DOTAP, DOPE, and cholesterol was prepared and optimized. The results showed that the liposome/DNA (LP/DNA) system had spherical morphology, with a particle size of around 150 nm and zeta potential of approximately 30 mV. Cytotoxicity experiments showed that cells treated with all of the liposome carriers- with the exception of LP1-had more than 80% viability even at a weight ratio of 30. The in vitro transfection efficiency was measured using a Promega™ Luciferase Assay System. Of the tested lipoplexes, LP2/DNA showed the highest cell transfection efficiency (at a weight ratio of 10)-which was similar to or slightly lower than that of Lipofectamine® 2000 in HeLa, A549, and SPC-A1 cell lines. After freeze-drying, the cell transfection efficiency decreased slightly (P&gt;0.05). The cell uptake mechanism study showed that LP/DNA lipoplexes mainly entered cells via clathrin-mediated and caveolin-mediated endocytic pathways. The results confirmed that LP2 has potential for use as an effective gene carrier, and provides experimental evidence to support its further development as a safe and effective gene delivery system.
DOI: 10.6084/m9.figshare.21835258
title: The impact of agricultural comprehensive development on agro-ecological efficiency of China - evidence from perspective of scale and structure

description: ABSTRACT: Promoting the agricultural sustainable development is one of the core objectives of agricultural comprehensive development (ACD), and the core of agricultural sustainable development lies in enhancing agro-ecological efficiency (AEE). Based on inter-provincial panel data from 2003-2017, the AEE was measured by a unexpected super-efficient SBM model. From the perspective of investment scale and investment structure, the impact of investment scale in ACD on AEE was examined using a panel econometric model, then characterizing the investment structure by the proportion of government funds in the investment of ACD, examining the non-linear relationship between investment structure of ACD and AEE seeking a reasonable proportion of government expenditure. Finally, a spatial econometric model was constructed to test the spatial spillover effect of the scale and structure of investment in ACD on AEE. Results showed that: (i) AEE of China is on the rise overall, but the efficiency level is still low and there is large scope for improvement. (ii) Due to the inefficient use of funds and the lag in the transformation of agricultural benefits, the scale of investment in ACD has a significant negative impact on AEE in the current period. (iii) The impact of investment structure of ACD on AEE presents a significant “inverted N” relationship, and the optimal proportion of government fund investment structure is 76.71%. The reasonable structure of investment in ACD at different food functional areas shows differences. (iv) After considering the spatial effect, the impact of ACD remains robust, but the spatial spillover effect prolongs the time lag of this impact of investment scale and starts to have a positive impact in the 2nd year after the investment. Guarantee the investment scale in ACD, reduce financial redundancy, establish a cooperation mechanism between ACD and agricultural ecological protection in neighboring areas, and increase the introduction of private capital can achieve sustainable development of agricultural economy.
DOI: 10.6084/m9.figshare.7679492
title: Additional file 2: of Structural rearrangements generate cell-specific, gene-independent CRISPR-Cas9 loss of fitness effects

description: Table S1. List of cancer cell lines included in the study. (XLSX 30 kb)
DOI: 10.6084/m9.figshare.12921990.v1
title: Rbm24 regulates inner-ear-specific alternative splicing and is essential for maintaining auditory and motor coordination

description: Tissue-specific alternative splicing (AS) is emerging as one of the most exciting types of mechanisms associated with organ development and disease. In the auditory system, many hearing-related genes undergo AS, and errors in this process result in syndromic or non-syndromic hearing loss. However, little is known about the factors and mechanisms directing AS in the inner ear. In the present study, we identified a novel RNA binding protein, Rbm24, which was critically involved in regulating inner-ear-specific AS. Rbm24 deletion resulted in hearing loss and defects in motor coordination. Global splicing analysis showed Rbm24 was required for correct splicing of a subset of pre-mRNA transcripts with essential roles in stereocilia integrity and survival of hair cells. Furthermore, we identified that Rbm24 directly regulated the splicing of Cdh23, a known disease gene responsible for human Usher syndrome 1D and non-syndromic autosomal recessive deafness DFNB12. In conclusion, our findings demonstrated that Rbm24 was a critical factor in regulating inner-ear-specific splicing and maintaining the hearing and motor coordination function of the inner ear. Our data not only offer mechanistic insights but also provide functional annotation of Rbm24 splicing targets that contribute to hearing loss.
DOI: 10.6084/m9.figshare.24981672
title: Kettle trap pollination in Arisaema erubescens

description: Data S1: The <i>COI</i> (mitochondrial cyto-chrome oxidase I) sequences of fungus gnats sampled from <i>Arisaema erubescens</i> using to identify pollinator and build the phylogenetic tree.
DOI: 10.15468/zwam82
title: Data from: Overwintering tropical herbivores accelerate detritus production on temperate reefs (2019)

description: This dataset is the abundances of the range-shifting tropical rabbitfish Siganus fuscescens and compared these with the most important kelp consumers native of temperate reefs of Western Australia: Kyphosus sydneyanus and Olisthops cyanomelas. The study was carried out at temperate rocky reefs in southwestern Australia where the rabbitfish S. fuscescens has established populations following a marine heatwave in 2011. See cited paper for methods and analysis.
DOI: 10.6084/m9.figshare.23254361.v1
title: Marine sediment data by Greenland marine-terminating glaciers

description: Source data file with basic with basic Information for all cores, including core positions, mass accumulation rates, and glaciological data for glaciers contributing meltwater to the fjords from where the cores were taken.
DOI: 10.25387/g3.8204582
title: Supplemental Material for Bewick et al., 2019

description: Supplementary Figures and Tables
DOI: 10.25387/g3.8204582.v1
title: Supplemental Material for Bewick et al., 2019

description: Supplementary Figures and Tables
DOI: 10.6084/m9.figshare.7680302
title: The MTOR signaling pathway regulates macrophage differentiation from mouse myeloid progenitors by inhibiting autophagy

description: Understanding of the mechanism for myeloid differentiation provides important insights into the hematopoietic developmental processes. By using an ESC-derived myeloid progenitor cell model, we found that CSF2/GM-CSF triggered macrophage differentiation and activation of the MTOR signaling pathway. Activation or inhibition of the MTOR signaling enhanced or attenuated macrophage differentiation, respectively, suggesting a critical function. We further showed that macroautophagy/autophagy was inhibited with the addition of CSF2. Furthermore, pharmacological inhibition and genetic modification of autophagy enhanced macrophage differentiation and rescued the inhibitory effect on differentiation caused by MTOR inhibition. Thus, the MTOR signaling pathway regulates macrophage differentiation of myeloid progenitors by inhibiting autophagy. Our results provide new insights into the mechanisms for myeloid differentiation and may prove useful for therapeutic applications of hematopoietic and myeloid progenitor cells. <b>Abbreviations:</b> 2-DG: 2-deoxy-D-glucose; ADGRE1/F4/80: adhesion G protein-coupled receptor E1; BM: bone marrow; CQ: chloroquine; ECAR: extracellular acidification rate; ESC: embryonic stem cell; CSF2/GM-CSF: colony stimulating factor 2; CSF3/G-CSF: colony stimulating factor 3; HPC: hematopoietic progenitor cell; ITGAM/CD11b: integrin alpha M; LPS: lipopolysaccharide; MFI: median fluorescence intensity; MTOR: mechanistic target of rapamycin kinase; RPS6KB1/p70S6K1: ribosomal protein S6 kinase, polypeptide 1; shRNA: short hairpin RNA; SQSTM1/p62: sequestosome 1.
DOI: 10.6084/m9.figshare.21310967.v1
title: Additional file 1 of Evaluation of the reliability of the upper lip bite test and the modified mallampati test in predicting difficult intubation under direct laryngoscopy in apparently normal patients: a prospective observational clinical study

description: Additional file 1.
DOI: 10.6084/m9.figshare.21310967
title: Additional file 1 of Evaluation of the reliability of the upper lip bite test and the modified mallampati test in predicting difficult intubation under direct laryngoscopy in apparently normal patients: a prospective observational clinical study

description: Additional file 1.
DOI: 10.6084/m9.figshare.21311015.v1
title: Additional file 3 of STAT3/miR-130b-3p/MBNL1 feedback loop regulated by mTORC1 signaling promotes angiogenesis and tumor growth

description: Additional file 3: Supplementary Table S7. List of the predict target genes of miR-130b-3p from prediction softwares TargetScan, RNA22, PicTar, miRDB and miRWalk.
DOI: 10.6084/m9.figshare.21311018
title: Additional file 4 of STAT3/miR-130b-3p/MBNL1 feedback loop regulated by mTORC1 signaling promotes angiogenesis and tumor growth

description: Additional file 4: Supplementary Table S8. List of the downregulated differentially expressed genes from RNA sequencing results in Tsc2-/- MEFs and Tsc2+/+ MEFs. All genes were identified with FDR-adjusted p-value&lt;0.05 and absolute value of log2(FC)&gt;1.
DOI: 10.6084/m9.figshare.21310989.v1
title: Additional file 1 of Comparison of different correction formulas and measurement methods for the accurate determination of intraocular pressure after SMILE and FS-LASIK surgery

description: Additional file 1.
DOI: 10.6084/m9.figshare.7679531
title: Additional file 8: of Transcriptome analysis reveals pathways facilitating the growth of tobacco powdery mildew in Arabidopsis

description: Table S9. List of differentially expressed UGT genes in pad4â 1 sid2â 1 and Col-0 (XLSX 23 kb)
DOI: 10.6084/m9.figshare.21311034.v1
title: Additional file 5 of Combining QTL mapping and RNA-Seq Unravels candidate genes for Alfalfa (Medicago sativa L.) leaf development

description: Additional file 5: Table S3. List of 2,061 up-regulated genes (‘sativa’ Vs ‘falcata’).
DOI: 10.6084/m9.figshare.21311037
title: Additional file 6 of Combining QTL mapping and RNA-Seq Unravels candidate genes for Alfalfa (Medicago sativa L.) leaf development

description: Additional file 6: Table S4. List of 1,709 down-regulated genes (‘sativa’ Vs ‘falcata’).
DOI: 10.6084/m9.figshare.21311015
title: Additional file 3 of STAT3/miR-130b-3p/MBNL1 feedback loop regulated by mTORC1 signaling promotes angiogenesis and tumor growth

description: Additional file 3: Supplementary Table S7. List of the predict target genes of miR-130b-3p from prediction softwares TargetScan, RNA22, PicTar, miRDB and miRWalk.
DOI: 10.6084/m9.figshare.21835372.v1
title: Impact of Coronary Artery Disease on The Outcomes of Catheter Ablation in Patients with Atrial Fibrillation

description: ABSTRACT Introduction: The objective of this study is to investigate the possible impact of coronary artery disease (CAD) on clinical outcomes of catheter ablation in patients with atrial fibrillation (AF). Methods: Patients with AF who underwent coronary computed tomography and catheter ablation were enrolled. The presence of stenotic severity and plaque, characteristics of coronary arteries, clinical data, and adverse outcomes of catheter ablation were analysed. Results: A total of 243 patients were enrolled, 100 (41%) patients with CAD. The CHA2DS2-VASc (congestive heart failure, hypertension, age ≥ 75 years, diabetes mellitus, stroke or transient ischemic attack, vascular disease, age 65-74 years, and sex category) score of AF patients with CAD was significantly (P&lt;0.001) higher than of those without CAD. Presence of stenotic artery and plaques increased significantly with increase of CHA2DS2-VASc score (P&lt;0.05). There was no significant (P=0.342) difference in AF recurrence between patients with and without CAD (30% versus 24%). Age, AF type, duration of AF, heart failure, CHA2DS2-VASc score, left ventricular ejection fraction, and left atrial diameter were significantly (P&lt;0.05) correlated with AF recurrence in univariant analysis. Multivariable analysis revealed that duration of AF (hazard ratio [HR] 1.769), heart failure (HR 1.821), and left atrial diameter (HR 1.487, P=0.022) remained significant independent predictors of AF recurrence. Patients with AF and concomitant CAD were significantly (P=0.030) associated with a worse outcome. Conclusion: CAD concomitant with AF may be associated with a worse clinical outcome even though CAD does not significantly affect the risk of AF recurrence after ablation therapy.
DOI: 10.6084/m9.figshare.16590834.v1
title: Additional file 1 of A genome-wide association analysis for body weight at 35 days measured on 137,343 broiler chickens

description: Additional file 1: Table S1. List of all significant SNPs sorted by significance1. SNP = name of the single nucleotide polymorphism; GGA = Gallus gallus chromosome; location (bp) = position of the SNP on the chromosome in base pairs on the Galgal4 assembly; MAF = minor allele frequency; EFF = allele substitution effect; SE = standard error of the effect; P-value = P-values from the single SNP regression while simultaneously correcting for the background polygenic effect; P-valueFDR = false discovery rate P-value; LOG = the −log10 of the P-value; VSNP = variance due to the SNP (calculated as 2pqb2, where p is the frequency of major allele, q = 1 − p is the frequency of the minor allele and b is the allele substitution effect); VA = additive genetic variance; VP = phenotypic variance; VAsnp (%) = percentage of additive genetic variance explained by each SNP; VPsnp (%) = percentage of phenotypic variance explained by each SNP. 1Of the 96 significant SNPs 18 are proprietary to Aviagen and therefore their base pair location has been excluded.
DOI: 10.6084/m9.figshare.21311018.v1
title: Additional file 4 of STAT3/miR-130b-3p/MBNL1 feedback loop regulated by mTORC1 signaling promotes angiogenesis and tumor growth

description: Additional file 4: Supplementary Table S8. List of the downregulated differentially expressed genes from RNA sequencing results in Tsc2-/- MEFs and Tsc2+/+ MEFs. All genes were identified with FDR-adjusted p-value&lt;0.05 and absolute value of log2(FC)&gt;1.
DOI: 10.15468/dl.r6f2cz
title: Occurrence Download

description: A dataset containing 402 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Cirsium obvallatum (M.Bieb.) M.Bieb."
 ]
}

 The dataset includes 402 records from 32 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0138543-230224095556074/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.7qg9bk
title: Occurrence Download

description: A dataset containing 2475 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Mischocyttarus Saussure, 1853"
 ]
}

 The dataset includes 2475 records from 26 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0004345-150831095807960/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.nacmpq
title: Occurrence Download

description: A dataset containing 18 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Castilleja virgata Dombey ex Wedd."
 ]
}

 The dataset includes 18 records from 2 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0007426-191105090559680/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.yfcamq
title: Occurrence Download

description: A dataset containing 1806 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Cirsium ochrocentrum A.Gray"
 ]
}

 The dataset includes 1806 records from 79 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0138547-230224095556074/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.3fbuby
title: Occurrence Download

description: A dataset containing 632 species occurrences available in GBIF matching the query:
{
 "and" : [
 "DatasetKey is KZNM-PINDIP-DIPTATEACH",
 "Issue is Taxon match fuzzy"
 ]
}

 The dataset includes 632 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0007430-191105090559680/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.cvqyow
title: Occurrence Download

description: A dataset containing 51252 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Aedes"
 ]
}

 The dataset includes 51252 records from 179 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0004345-160118175350007/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.y92jwd
title: Occurrence Download

description: A dataset containing 1541 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Geometry POLYGON((-72.23099 11.8781,-72.15134 11.82165,-71.92337 12.13869,-71.9783 12.14406,-72.00577 12.18165,-71.95908 12.24071,-72.10739 12.22192,-72.1431 12.20313,-72.14584 12.09304,-72.20901 11.92917,-72.23099 11.8781))",
 "HasGeospatialIssue is false"
 ]
}

 The dataset includes 1541 records from 24 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0008095-210914110416597/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.