cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.11925963
title: Supplementary Material for: Frequency and Clinical Impact of Serious Adverse Events on Post-Stroke Recovery with NeuroAiD (MLC601) versus Placebo: The CHInese Medicine Neuroaid Efficacy on Stroke Recovery Study

description: <b><i>Background:</i></b> Most comparative clinical trials are designed to assess the treatment effect for efficacy endpoints, with less emphasis on the analysis of safety outcomes. However, an extensive analysis of safety data could demonstrate beneficial results in terms of effectiveness by reducing serious adverse events (SAEs), and their unfavourable clinical impact on the study population. We aimed to conduct an exploratory analysis of the CHInese Medicine Neuroaid Efficacy on Stroke recovery (CHIMES) study safety database comparing the frequency of SAEs and their clinical impacts among subjects having received MLC601 or placebo during the first 3 months post-stroke. <b><i>Methods:</i></b> Analyses were performed by using the safety database of the multicentre, randomised, double-blind, placebo-controlled CHIMES study of 3 months of NeuroAiD versus placebo in subjects with acute ischaemic stroke of intermediate severity in the preceding 72 h. SAEs as reported by investigators at any time-point during the 3-month study were analysed on their frequency and that of any of their outcomes (death, and life threatening, new and/or prolonged hospitalisation, disability, and medical importance, in surviving subjects), as well as their time to onset and resolution. <b><i>Results:</i></b> Of the 1,099 subjects in the CHIMES study, 1,087 were included in the safety analysis (MLC601 = 542) and (placebo = 545); the 12 who did not receive study treatment were excluded. There was a total of 135 subjects with SAEs (MLC601 = 60, placebo = 75). At baseline, overall, subjects with SAEs were older and had lower MMSE score. In the MLC601 group, they had higher NIHSS score, and more frequently a history of ischaemic heart disease and hyperlipidaemia. The number of SAEs per subjects was statistically significantly lower in the MLC601 group than placebo one, especially for subjects with ≥2 SAEs (6.7 vs. 29.3%; <i>p</i> &lt; 0.001). This benefit was seen throughout the study period and during the initial hospitalisation. The main clinical impact of SAEs was an increase in hospitalisation time, reduced in the MLC601 arm with the rate of subjects hospitalised for a prolonged period being significantly threefold lower in surviving subjects (1.1 vs. 3.7%; <i>p</i> &lt; 0.01). <b><i>Conclusions:</i></b> This post hoc analysis of SAEs from the CHIMES study database shows that subjects receiving a 3-month course of MLC601 experienced fewer SAEs, with lower rates of harmful clinical impacts, especially in terms of hospitalisation duration. These findings could translate to a benefit in terms of reduction of both healthcare burden and additional medical costs.
DOI: 10.6084/m9.figshare.11925963.v1
title: Supplementary Material for: Frequency and Clinical Impact of Serious Adverse Events on Post-Stroke Recovery with NeuroAiD (MLC601) versus Placebo: The CHInese Medicine Neuroaid Efficacy on Stroke Recovery Study

description: <b><i>Background:</i></b> Most comparative clinical trials are designed to assess the treatment effect for efficacy endpoints, with less emphasis on the analysis of safety outcomes. However, an extensive analysis of safety data could demonstrate beneficial results in terms of effectiveness by reducing serious adverse events (SAEs), and their unfavourable clinical impact on the study population. We aimed to conduct an exploratory analysis of the CHInese Medicine Neuroaid Efficacy on Stroke recovery (CHIMES) study safety database comparing the frequency of SAEs and their clinical impacts among subjects having received MLC601 or placebo during the first 3 months post-stroke. <b><i>Methods:</i></b> Analyses were performed by using the safety database of the multicentre, randomised, double-blind, placebo-controlled CHIMES study of 3 months of NeuroAiD versus placebo in subjects with acute ischaemic stroke of intermediate severity in the preceding 72 h. SAEs as reported by investigators at any time-point during the 3-month study were analysed on their frequency and that of any of their outcomes (death, and life threatening, new and/or prolonged hospitalisation, disability, and medical importance, in surviving subjects), as well as their time to onset and resolution. <b><i>Results:</i></b> Of the 1,099 subjects in the CHIMES study, 1,087 were included in the safety analysis (MLC601 = 542) and (placebo = 545); the 12 who did not receive study treatment were excluded. There was a total of 135 subjects with SAEs (MLC601 = 60, placebo = 75). At baseline, overall, subjects with SAEs were older and had lower MMSE score. In the MLC601 group, they had higher NIHSS score, and more frequently a history of ischaemic heart disease and hyperlipidaemia. The number of SAEs per subjects was statistically significantly lower in the MLC601 group than placebo one, especially for subjects with ≥2 SAEs (6.7 vs. 29.3%; <i>p</i> &lt; 0.001). This benefit was seen throughout the study period and during the initial hospitalisation. The main clinical impact of SAEs was an increase in hospitalisation time, reduced in the MLC601 arm with the rate of subjects hospitalised for a prolonged period being significantly threefold lower in surviving subjects (1.1 vs. 3.7%; <i>p</i> &lt; 0.01). <b><i>Conclusions:</i></b> This post hoc analysis of SAEs from the CHIMES study database shows that subjects receiving a 3-month course of MLC601 experienced fewer SAEs, with lower rates of harmful clinical impacts, especially in terms of hospitalisation duration. These findings could translate to a benefit in terms of reduction of both healthcare burden and additional medical costs.
DOI: 10.6084/m9.figshare.11925984
title: Supplementary Material for: Consumer Preferences for Skin Cancer Screening Using Mobile Teledermoscopy: A Qualitative Study

description: <b><i>Background:</i></b> Mobile teledermoscopy is a rapidly advancing technology that promotes early detection and management of skin cancers. Whilst the use of teledermoscopy has proven to be effective and has a role in the detection of skin cancers, patients’ attitudes towards the multiple ways in which this technology can be utilised has not been explored. <b><i>Methods:</i></b> Data were obtained from a large randomised controlled trial comparing mobile teledermoscopy-enhanced skin self-examinations (SSEs) with naked-eye SSE. A semi-structured interview guide was developed by the investigators with questions focusing on people’s previous skin screening behaviours and 2 of the major pathways which can be utilised in mobile teledermoscopy: (i) direct-to-consumer and (ii) doctor-to-doctor. All interviews were tape-recorded and transcribed verbatim. Thematic analysis was undertaken by 2 independent researchers. <b><i>Results:</i></b> Twenty-eight participants were interviewed. Eighty-six percent of participants (<i>n</i> = 24/28) had previously had a clinical skin examination. Only 18% of participants (<i>n</i> = 5/28) visited the same doctor for each clinical skin examination. Five main themes were identified in the interviews that affected how people felt about the integration of mobile teledermoscopy into skin screening pathways: history of clinical skin examinations, continuity of the doctor-patient relationship, convenience of the direct-to-consumer teledermoscopy, expedited review enhancing the doctor-to-doctor setting and mobile teledermoscopy as a partner-assisted task. <b><i>Conclusions:</i></b> Overall mobile teledermoscopy was viewed positively for both direct-to-consumer and doctor-to-doctor interaction. Continuity of care in the doctor-patient relationship was not found to be a priority for clinical skin examination with most participants visiting several doctors throughout their clinical skin examination history.
DOI: 10.6084/m9.figshare.11925984.v1
title: Supplementary Material for: Consumer Preferences for Skin Cancer Screening Using Mobile Teledermoscopy: A Qualitative Study

description: <b><i>Background:</i></b> Mobile teledermoscopy is a rapidly advancing technology that promotes early detection and management of skin cancers. Whilst the use of teledermoscopy has proven to be effective and has a role in the detection of skin cancers, patients’ attitudes towards the multiple ways in which this technology can be utilised has not been explored. <b><i>Methods:</i></b> Data were obtained from a large randomised controlled trial comparing mobile teledermoscopy-enhanced skin self-examinations (SSEs) with naked-eye SSE. A semi-structured interview guide was developed by the investigators with questions focusing on people’s previous skin screening behaviours and 2 of the major pathways which can be utilised in mobile teledermoscopy: (i) direct-to-consumer and (ii) doctor-to-doctor. All interviews were tape-recorded and transcribed verbatim. Thematic analysis was undertaken by 2 independent researchers. <b><i>Results:</i></b> Twenty-eight participants were interviewed. Eighty-six percent of participants (<i>n</i> = 24/28) had previously had a clinical skin examination. Only 18% of participants (<i>n</i> = 5/28) visited the same doctor for each clinical skin examination. Five main themes were identified in the interviews that affected how people felt about the integration of mobile teledermoscopy into skin screening pathways: history of clinical skin examinations, continuity of the doctor-patient relationship, convenience of the direct-to-consumer teledermoscopy, expedited review enhancing the doctor-to-doctor setting and mobile teledermoscopy as a partner-assisted task. <b><i>Conclusions:</i></b> Overall mobile teledermoscopy was viewed positively for both direct-to-consumer and doctor-to-doctor interaction. Continuity of care in the doctor-patient relationship was not found to be a priority for clinical skin examination with most participants visiting several doctors throughout their clinical skin examination history.
DOI: 10.6084/m9.figshare.11925948
title: straits.txt from Functional volumes, niche packing and species richness: biogeographic legacies in the Congo Basin

description: Code for "Functional volumes, niche packing, and species richness: biogeographic legacies in the Congo Basin"
DOI: 10.6084/m9.figshare.11925948.v2
title: straits.txt from Functional volumes, niche packing and species richness: biogeographic legacies in the Congo Basin

description: Code for "Functional volumes, niche packing, and species richness: biogeographic legacies in the Congo Basin"
DOI: 10.6084/m9.figshare.11925948.v1
title: straits.txt from Functional volumes, niche packing and species richness: biogeographic legacies in the Congo Basin

description: Code for "Functional volumes, niche packing, and species richness: biogeographic legacies in the Congo Basin"
DOI: 10.6084/m9.figshare.11925942
title: Running example of the KAIS Submission

description: These are the files submitted as part of the KAIS submission. The following files are provided:customers.sql - the "Customers" tableconsent-knowledge-base.ttl - consent information over time of 10 users and 5 systems.The Consent Knowledge Base resulted from applying the R2RML mapping to the database containing the synthetic data:data.sql - the synthetic dataset as a MySQL dumpmapping.ttl - the R2RML mapping from the database to the ontology
DOI: 10.6084/m9.figshare.11925942.v1
title: Running example of the KAIS Submission

description: These are the files submitted as part of the KAIS submission. The following files are provided:customers.sql - the "Customers" tableconsent-knowledge-base.ttl - consent information over time of 10 users and 5 systems.The Consent Knowledge Base resulted from applying the R2RML mapping to the database containing the synthetic data:data.sql - the synthetic dataset as a MySQL dumpmapping.ttl - the R2RML mapping from the database to the ontology
DOI: 10.6084/m9.figshare.11925912
title: Supplementary Table 1 from Nutritional regulation of glucose metabolism-related genes in the emerging teleost model Mexican tetra surface fish: a first exploration

description: Primers sequences used in the present study.
DOI: 10.6084/m9.figshare.11925909
title: Datesets from Individual differences in human voice pitch are preserved from speech to screams, roars and pain cries

description: Fundamental frequency (<i>F</i>0, perceived as voice pitch) predicts sex and age, hormonal status, mating success and a range of social traits, and thus functions as an important biosocial marker in modal speech. Yet, the role of <i>F</i>0 in human nonverbal vocalizations remains unclear, and given considerable variability in <i>F</i>0 across call types, it is not known whether <i>F</i>0 cues to vocalizer attributes are shared across speech and nonverbal vocalizations. Here, using a corpus of vocal sounds from 51 men and women, we examined whether individual differences in <i>F</i>0 are retained across neutral speech, valenced speech and nonverbal vocalizations (screams, roars and pain cries). Acoustic analyses revealed substantial variability in <i>F</i>0 across vocal types, with mean <i>F</i>0 increasing as much as 10-fold in screams compared to speech in the same individual. Despite these extreme pitch differences, sexual dimorphism was preserved within call types and, critically, inter-individual differences in <i>F</i>0 correlated across vocal types (<i>r</i> = 0.36–0.80) with stronger relationships between vocal types of the same valence (e.g. 38% of the variance in roar <i>F</i>0 was predicted by aggressive speech <i>F</i>0). Our results indicate that biologically and socially relevant indexical cues in the human voice are preserved in simulated valenced speech and vocalizations, including vocalizations characterized by extreme <i>F</i>0 modulation, suggesting that voice pitch may function as a reliable individual and biosocial marker across disparate communication contexts.
DOI: 10.6084/m9.figshare.11925906
title: Supplemental tables from Individual differences in human voice pitch are preserved from speech to screams, roars and pain cries

description: Tables S1 - S4
DOI: 10.6084/m9.figshare.11925912.v1
title: Supplementary Table 1 from Nutritional regulation of glucose metabolism-related genes in the emerging teleost model Mexican tetra surface fish: a first exploration

description: Primers sequences used in the present study.
DOI: 10.6084/m9.figshare.11925903
title: Script 2 from Individual differences in human voice pitch are preserved from speech to screams, roars and pain cries

description: Statistical analysis scripts
DOI: 10.6084/m9.figshare.11925906.v1
title: Supplemental tables from Individual differences in human voice pitch are preserved from speech to screams, roars and pain cries

description: Tables S1 - S4
DOI: 10.6084/m9.figshare.11925909.v1
title: Datesets from Individual differences in human voice pitch are preserved from speech to screams, roars and pain cries

description: Fundamental frequency (<i>F</i>0, perceived as voice pitch) predicts sex and age, hormonal status, mating success and a range of social traits, and thus functions as an important biosocial marker in modal speech. Yet, the role of <i>F</i>0 in human nonverbal vocalizations remains unclear, and given considerable variability in <i>F</i>0 across call types, it is not known whether <i>F</i>0 cues to vocalizer attributes are shared across speech and nonverbal vocalizations. Here, using a corpus of vocal sounds from 51 men and women, we examined whether individual differences in <i>F</i>0 are retained across neutral speech, valenced speech and nonverbal vocalizations (screams, roars and pain cries). Acoustic analyses revealed substantial variability in <i>F</i>0 across vocal types, with mean <i>F</i>0 increasing as much as 10-fold in screams compared to speech in the same individual. Despite these extreme pitch differences, sexual dimorphism was preserved within call types and, critically, inter-individual differences in <i>F</i>0 correlated across vocal types (<i>r</i> = 0.36–0.80) with stronger relationships between vocal types of the same valence (e.g. 38% of the variance in roar <i>F</i>0 was predicted by aggressive speech <i>F</i>0). Our results indicate that biologically and socially relevant indexical cues in the human voice are preserved in simulated valenced speech and vocalizations, including vocalizations characterized by extreme <i>F</i>0 modulation, suggesting that voice pitch may function as a reliable individual and biosocial marker across disparate communication contexts.
DOI: 10.6084/m9.figshare.11925900
title: Script 1 from Individual differences in human voice pitch are preserved from speech to screams, roars and pain cries

description: Statistical analysis scripts
DOI: 10.6084/m9.figshare.11925903.v1
title: Script 2 from Individual differences in human voice pitch are preserved from speech to screams, roars and pain cries

description: Statistical analysis scripts
DOI: 10.6084/m9.figshare.11925894
title: Supplementary table 3 from Mid and hindgut transcriptome profiling analysis of Atlantic salmon (<i>Salmon salar</i>) under unpredictable chronic stress

description: List of all expressed genes discovered in the hindgut, including the differential expression results - log fold change difference and adjusted p values - between CS and control groups. Genes are annotated with Entrez ID, gene symbol and gene description.
DOI: 10.6084/m9.figshare.11925900.v1
title: Script 1 from Individual differences in human voice pitch are preserved from speech to screams, roars and pain cries

description: Statistical analysis scripts
DOI: 10.6084/m9.figshare.11925891
title: Supplementary table 6 from Mid and hindgut transcriptome profiling analysis of Atlantic salmon (<i>Salmon salar</i>) under unpredictable chronic stress

description: List of genes that were significantly differentially expressed in both midgut vs control and hindgut vs control. Includes log fold change difference and adjusted p values for both midgut and hindgut and genes are annotated with Entrez ID, gene symbol and gene description.
DOI: 10.6084/m9.figshare.11925894.v1
title: Supplementary table 3 from Mid and hindgut transcriptome profiling analysis of Atlantic salmon (<i>Salmon salar</i>) under unpredictable chronic stress

description: List of all expressed genes discovered in the hindgut, including the differential expression results - log fold change difference and adjusted p values - between CS and control groups. Genes are annotated with Entrez ID, gene symbol and gene description.
DOI: 10.6084/m9.figshare.11925885
title: Analysis pipeline for R. from Mid and hindgut transcriptome profiling analysis of Atlantic salmon (<i>Salmon salar</i>) under unpredictable chronic stress

description: R code
DOI: 10.6084/m9.figshare.11925891.v1
title: Supplementary table 6 from Mid and hindgut transcriptome profiling analysis of Atlantic salmon (<i>Salmon salar</i>) under unpredictable chronic stress

description: List of genes that were significantly differentially expressed in both midgut vs control and hindgut vs control. Includes log fold change difference and adjusted p values for both midgut and hindgut and genes are annotated with Entrez ID, gene symbol and gene description.
DOI: 10.6084/m9.figshare.11925885.v1
title: Analysis pipeline for R. from Mid and hindgut transcriptome profiling analysis of Atlantic salmon (<i>Salmon salar</i>) under unpredictable chronic stress

description: R code
DOI: 10.6084/m9.figshare.11925879
title: Supplementary table 4 from Mid and hindgut transcriptome profiling analysis of Atlantic salmon (<i>Salmon salar</i>) under unpredictable chronic stress

description: List of all expressed genes discovered in the midgut, including the differential expression results - log fold change difference and adjusted p values - between CS and control groups. Genes are annotated with Entrez ID, gene symbol and gene description.
DOI: 10.6084/m9.figshare.11925876
title: Supplementary table 5 from Mid and hindgut transcriptome profiling analysis of Atlantic salmon (<i>Salmon salar</i>) under unpredictable chronic stress

description: Significantly enriched KEGG pathways for genes differentially expressed in both midgut and hindgut.. Genes have been annotated with Entrez gene ID, Gene symbol and gene description. DE data (log fold change and adjusted p value) in both midgut and hindgut has been included for each gene.
DOI: 10.6084/m9.figshare.11925879.v1
title: Supplementary table 4 from Mid and hindgut transcriptome profiling analysis of Atlantic salmon (<i>Salmon salar</i>) under unpredictable chronic stress

description: List of all expressed genes discovered in the midgut, including the differential expression results - log fold change difference and adjusted p values - between CS and control groups. Genes are annotated with Entrez ID, gene symbol and gene description.
DOI: 10.6084/m9.figshare.11925876.v1
title: Supplementary table 5 from Mid and hindgut transcriptome profiling analysis of Atlantic salmon (<i>Salmon salar</i>) under unpredictable chronic stress

description: Significantly enriched KEGG pathways for genes differentially expressed in both midgut and hindgut.. Genes have been annotated with Entrez gene ID, Gene symbol and gene description. DE data (log fold change and adjusted p value) in both midgut and hindgut has been included for each gene.
DOI: 10.6084/m9.figshare.11925870
title: Dataset from Multiple nest entrances alter foraging and information transfer in ants

description: This file includes the data of the figures and the table of the manuscript.
DOI: 10.6084/m9.figshare.11925873
title: Supplementary table 2 from Mid and hindgut transcriptome profiling analysis of Atlantic salmon (<i>Salmon salar</i>) under unpredictable chronic stress

description: Significantly enriched KEGG pathways for CS hindgut and the DE genes found within the enriched pathways. Genes have been annotated with Entrez gene ID, Gene symbol and gene description. DE data (log fold change and adjusted p value) has been included for each gene. A condensed version of this table (showing only gene symbols) can be seen in Table 4 in the body of this article.
DOI: 10.6084/m9.figshare.11925870.v1
title: Dataset from Multiple nest entrances alter foraging and information transfer in ants

description: This file includes the data of the figures and the table of the manuscript.
DOI: 10.6084/m9.figshare.11925873.v1
title: Supplementary table 2 from Mid and hindgut transcriptome profiling analysis of Atlantic salmon (<i>Salmon salar</i>) under unpredictable chronic stress

description: Significantly enriched KEGG pathways for CS hindgut and the DE genes found within the enriched pathways. Genes have been annotated with Entrez gene ID, Gene symbol and gene description. DE data (log fold change and adjusted p value) has been included for each gene. A condensed version of this table (showing only gene symbols) can be seen in Table 4 in the body of this article.