cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.27117207.v1
title: Elucidating the immune landscape and potential prognostic model in acute myeloid leukemia with TP53 mutation

description: The TP53 mutation, a prevalent tumor suppressor gene alteration, is linked to chemotherapy resistance, increased relapse rates and diminished overall survival (OS) in acute myeloid leukemia (AML) patients. In this study, we characterize the TP53 mutation phenotypes across various AML cohorts utilizing The Cancer Genome Atlas (TCGA) data. We devised a TP53-related prognostic signature derived from differentially expressed genes between mutated and wild-type TP53 AML specimens. In-depth analyses were conducted, encompassing genetic variation, immune cell infiltration and prognostic stratification. A six-gene TP53-related signature was established using least absolute shrinkage and selection operator (LASSO)–Cox regression, demonstrating robust prognostic predictability. This signature exhibited strong performance in both the OHSU validation cohorts, an independent Gene Expression Omnibus (GEO) validation cohort (GSE71014) and proved by results of the in vivo experiment. Finally, we used single cell database (GSE198681) to observe the characteristics of these six genes. Our study may facilitate the development of efficacious therapeutic approaches and provide a novel idea for future research. Conclusion: The TP53-related signature and pattern hold the potential to refine prognostic stratification and underscore emerging targeted therapies.
DOI: 10.3886/e213184v1
title: Semi-structured interviews with laypeople about administering CPR

description: This study was guided by the Theory of Planned Behavior. A total of 29 respondents from diverse age groups, occupations, and regions were recruited through both online and offline purposive sampling methods to investigate the underlying reasons for the current low rate of cardiopulmonary resuscitation (CPR) implementation among lay rescuers.
description: Response Rates: A total of 29 lay people were included in the study
description: Purposive sampling
description: A lay rescuer was defined as an individual without specialized healthcare training or limited to basic life support or portable defibrillator training.
description: face-to-face interview; other; Interviews were conducted either in-person or online via video. Two researchers attended each interview: one conducted the interview while the other observed nonverbal cues.
DOI: 10.6084/m9.figshare.27314375
title: SRSF12 is a prognostic biomarker involved in immune infiltration in acute myeloid leukemia

description: Acute myeloid leukemia (AML) is a disease characterized by the proliferation of abnormal cells originating from blood stem cells. Understanding the pathogenesis and progression of AML, as well as identifying molecular markers for early diagnosis and prognosis assessment, is of paramount importance. The AML dataset was obtained from the Cancer Genome Atlas (TCGA), while the normal sample dataset was derived from the Genotype-Tissue Expression(GTEx) dataset. Furthermore, the association between SRSF12 expression and drug response was assessed using the Cancer Therapeutic Response Portal (CTRP) database to evaluate its potential therapeutic value. Finally, SRSF12 expression in AML cells was measured using quantitative real-time PCR (qRT-PCR). The difference in SRSF12 expression between 13 types of tumors and normal tissue samples was found to be statistically significant (<i>P</i> &lt; 0.05). SRSF12 exhibited predominantly high expression in AML, indicating its potential as a diagnostic and prognostic marker for AML patients. High expression of SRSF12, along with age and cytogenetic risk, emerged as independent predictors of favorable prognosis in AML patients (<i>P</i> &lt; 0.05). PCR demonstrated a significant increase in SRSF12 expression in AML patients. Overall, our findings suggest that the high expression of SRSF12 in AML patients is a poor prognostic factor, which may provide a new option for the diagnosis, and targeted therapy of AML. <b>What is the context?</b> Acute myeloid leukemia (AML) is a malignant clonal disease originating from hematopoietic stem progenitor cells. It is of great significance to identify the pathogenesis and development of AML and to search for molecular markers for early diagnosis and prognosis assessment. <b>What is new?</b> In this study, the expression of SRSF12 in AML patients was analyzed by bioinformatics and RT-qPCR, and the relationship between clinical traits and prognosis was analyzed, and it was found that SRSF12 was highly expressed in AML tissues, and in addition, high expression of SRSF12 was associated with good prognosis of patients, and its expression was correlated with white blood cell count, FAB stage and cytogenetics. Enrichment analysis showed that SRSF12 was mainly involved in PI3K-AKT signaling pathway, Jak-STA signaling pathway, etc., and the expression of SRSF12 was positively correlated with helper T cell infiltration, but negatively correlated with neutrophil and macrophage infiltration. PPI analysis showed that SRSF12 interacted with SRSF11 and other proteins, and we also found that SRSF12 expression was significantly associated with a variety of drugs in hematopoietic and lymphoid tissues. <b>What is the impact?</b> This study provides further evidence to prove it, SRSF12 may be used as a new potential biomarker to predict the prognosis and guide the precise diagnosis and treatment of patients in the future.
DOI: 10.6084/m9.figshare.27314375.v1
title: SRSF12 is a prognostic biomarker involved in immune infiltration in acute myeloid leukemia

description: Acute myeloid leukemia (AML) is a disease characterized by the proliferation of abnormal cells originating from blood stem cells. Understanding the pathogenesis and progression of AML, as well as identifying molecular markers for early diagnosis and prognosis assessment, is of paramount importance. The AML dataset was obtained from the Cancer Genome Atlas (TCGA), while the normal sample dataset was derived from the Genotype-Tissue Expression(GTEx) dataset. Furthermore, the association between SRSF12 expression and drug response was assessed using the Cancer Therapeutic Response Portal (CTRP) database to evaluate its potential therapeutic value. Finally, SRSF12 expression in AML cells was measured using quantitative real-time PCR (qRT-PCR). The difference in SRSF12 expression between 13 types of tumors and normal tissue samples was found to be statistically significant (<i>P</i> &lt; 0.05). SRSF12 exhibited predominantly high expression in AML, indicating its potential as a diagnostic and prognostic marker for AML patients. High expression of SRSF12, along with age and cytogenetic risk, emerged as independent predictors of favorable prognosis in AML patients (<i>P</i> &lt; 0.05). PCR demonstrated a significant increase in SRSF12 expression in AML patients. Overall, our findings suggest that the high expression of SRSF12 in AML patients is a poor prognostic factor, which may provide a new option for the diagnosis, and targeted therapy of AML. <b>What is the context?</b> Acute myeloid leukemia (AML) is a malignant clonal disease originating from hematopoietic stem progenitor cells. It is of great significance to identify the pathogenesis and development of AML and to search for molecular markers for early diagnosis and prognosis assessment. <b>What is new?</b> In this study, the expression of SRSF12 in AML patients was analyzed by bioinformatics and RT-qPCR, and the relationship between clinical traits and prognosis was analyzed, and it was found that SRSF12 was highly expressed in AML tissues, and in addition, high expression of SRSF12 was associated with good prognosis of patients, and its expression was correlated with white blood cell count, FAB stage and cytogenetics. Enrichment analysis showed that SRSF12 was mainly involved in PI3K-AKT signaling pathway, Jak-STA signaling pathway, etc., and the expression of SRSF12 was positively correlated with helper T cell infiltration, but negatively correlated with neutrophil and macrophage infiltration. PPI analysis showed that SRSF12 interacted with SRSF11 and other proteins, and we also found that SRSF12 expression was significantly associated with a variety of drugs in hematopoietic and lymphoid tissues. <b>What is the impact?</b> This study provides further evidence to prove it, SRSF12 may be used as a new potential biomarker to predict the prognosis and guide the precise diagnosis and treatment of patients in the future.
DOI: 10.3886/e213184
title: Semi-structured interviews with laypeople about administering CPR

description: This study was guided by the Theory of Planned Behavior. A total of 29 respondents from diverse age groups, occupations, and regions were recruited through both online and offline purposive sampling methods to investigate the underlying reasons for the current low rate of cardiopulmonary resuscitation (CPR) implementation among lay rescuers.
description: Response Rates: A total of 29 lay people were included in the study
description: Purposive sampling
description: A lay rescuer was defined as an individual without specialized healthcare training or limited to basic life support or portable defibrillator training.
description: face-to-face interview; other; Interviews were conducted either in-person or online via video. Two researchers attended each interview: one conducted the interview while the other observed nonverbal cues.
DOI: 10.3886/e213184v2
title: Semi-structured interviews with laypeople about administering CPR

description: This study was guided by the Theory of Planned Behavior. A total of 29 respondents from diverse age groups, occupations, and regions were recruited through both online and offline purposive sampling methods to investigate the underlying reasons for the current low rate of cardiopulmonary resuscitation (CPR) implementation among lay rescuers.
description: Response Rates: A total of 29 lay people were included in the study
description: Purposive sampling
description: A lay rescuer was defined as an individual without specialized healthcare training or limited to basic life support or portable defibrillator training.
description: face-to-face interview; other; Interviews were conducted either in-person or online via video. Two researchers attended each interview: one conducted the interview while the other observed nonverbal cues.
DOI: 10.6084/m9.figshare.24807294
title: Cognitive-behavioral stress management relieves anxiety, depression, and post-traumatic stress disorder in parents of pediatric acute myeloid leukemia patients: a randomized, controlled study

description: Cognitive-behavioral stress management (CBSM) is an effective psychological intervention to relieve psychological and symptomatic distress. This study aimed to investigate the effect of CBSM in anxiety, depression, and post-traumatic stress disorder (PTSD) in parents of pediatric acute myeloid leukemia (AML) patients. Totally, 56 pediatric AML patients and 100 parents were randomized into the CBSM group (28 patients and 49 parents) and the normal control (NC) group (28 patients and 51 parents) to receive corresponding interventions for 10 weeks. The questionnaire scores were assessed at month M0, M1, M3, and M6. In parents of pediatric AML patients, self-rating anxiety scale score at M1 (<i>p </i>= 0.034), M3 (<i>p </i>= 0.010), and M6 (<i>p </i>= 0.003), as well as anxiety at M3 (<i>p </i>= 0.036) and M6 (<i>p </i>= 0.012) were decreased in the CBSM group versus the NC group. Self-rating depression scale score at M3 (<i>p </i>= 0.022) and M6 (<i>p </i>= 0.002), as well as depression at M6 (<i>p </i>= 0.019) were declined in the CBSM group versus the NC group. Symptom checklist-90 (a psychotic status questionnaire) score at M3 (<i>p </i>= 0.031) and M6 (<i>p </i>= 0.019) were declined in the CBSM group versus the NC group. Regarding PTSD, the impact of the events scale-revised score at M3 (<i>p </i>= 0.044) and M6 (<i>p </i>= 0.010) were decreased in the CBSM group versus the NC group. By subgroup analyses CBSM (versus NC) improved all outcomes in parents with anxiety at M0 and depression at M0 (all <i>p </i>&lt; 0.050), but could not affect the outcomes in parents without anxiety or depression at M0 (all <i>p </i>&gt; 0.050). CBSM reduces anxiety, depression, and PTSD in parents of pediatric AML patients.
DOI: 10.6084/m9.figshare.24807294.v1
title: Cognitive-behavioral stress management relieves anxiety, depression, and post-traumatic stress disorder in parents of pediatric acute myeloid leukemia patients: a randomized, controlled study

description: Cognitive-behavioral stress management (CBSM) is an effective psychological intervention to relieve psychological and symptomatic distress. This study aimed to investigate the effect of CBSM in anxiety, depression, and post-traumatic stress disorder (PTSD) in parents of pediatric acute myeloid leukemia (AML) patients. Totally, 56 pediatric AML patients and 100 parents were randomized into the CBSM group (28 patients and 49 parents) and the normal control (NC) group (28 patients and 51 parents) to receive corresponding interventions for 10 weeks. The questionnaire scores were assessed at month M0, M1, M3, and M6. In parents of pediatric AML patients, self-rating anxiety scale score at M1 (<i>p </i>= 0.034), M3 (<i>p </i>= 0.010), and M6 (<i>p </i>= 0.003), as well as anxiety at M3 (<i>p </i>= 0.036) and M6 (<i>p </i>= 0.012) were decreased in the CBSM group versus the NC group. Self-rating depression scale score at M3 (<i>p </i>= 0.022) and M6 (<i>p </i>= 0.002), as well as depression at M6 (<i>p </i>= 0.019) were declined in the CBSM group versus the NC group. Symptom checklist-90 (a psychotic status questionnaire) score at M3 (<i>p </i>= 0.031) and M6 (<i>p </i>= 0.019) were declined in the CBSM group versus the NC group. Regarding PTSD, the impact of the events scale-revised score at M3 (<i>p </i>= 0.044) and M6 (<i>p </i>= 0.010) were decreased in the CBSM group versus the NC group. By subgroup analyses CBSM (versus NC) improved all outcomes in parents with anxiety at M0 and depression at M0 (all <i>p </i>&lt; 0.050), but could not affect the outcomes in parents without anxiety or depression at M0 (all <i>p </i>&gt; 0.050). CBSM reduces anxiety, depression, and PTSD in parents of pediatric AML patients.
DOI: 10.6084/m9.figshare.27161886
title: Clinical features and long-term outcomes of pediatric patients with de novo acute myeloid leukemia in China with or without specific gene abnormalities: a cohort study of patients treated with BCH-AML 2005

description: Acute myeloid leukemia (AML), which has distinct genetic abnormalities, has unique clinical and biological features. In this study, the incidence, clinical characteristics, induction treatment response, and outcomes of a large cohort of Chinese AML pediatric patients treated according to the BCH-AML 2005 protocol were analyzed. <i>RUNX1-RUNX1T1</i> was the most common fusion transcript, followed by the <i>CBFβ-MHY11</i> and <i>KMT2A</i> rearrangements. <i>FLT3</i>-ITD and <i>KIT</i> mutations are associated with unfavorable clinical features and induction responses, along with <i>KMT2A</i> rearrangements, <i>DEK-NUP214</i>, and CBF-AML. The 5-year event-free survival (EFS) and overall survival (OS) rates of our cohort were 53.9 ± 3.7% and 58.5 ± 3.6%, with the best survival found among patients with <i>CBFβ-MYH11</i> and the worst survival among those with <i>DEK-NUP214</i>. In addition, we found that patients with <i>FLT3</i>-ITD mutation had adverse outcomes and that <i>KIT</i> mutation had a negative impact on OS in <i>RUNX1-RUNX1T1</i><sup>+</sup> patients. Furthermore, the risk classification and response to treatment after each induction block also influenced the prognosis, and HSCT after first remission could improve OS in high-risk patients. Not achieving complete remission after induction 2 was found to be an independent prognostic factor for OS and EFS. These findings indicate that genetic abnormalities could be considered stratification factors, predict patient outcomes, and imply the application of targeted therapy.
DOI: 10.6084/m9.figshare.27161886.v1
title: Clinical features and long-term outcomes of pediatric patients with de novo acute myeloid leukemia in China with or without specific gene abnormalities: a cohort study of patients treated with BCH-AML 2005

description: Acute myeloid leukemia (AML), which has distinct genetic abnormalities, has unique clinical and biological features. In this study, the incidence, clinical characteristics, induction treatment response, and outcomes of a large cohort of Chinese AML pediatric patients treated according to the BCH-AML 2005 protocol were analyzed. <i>RUNX1-RUNX1T1</i> was the most common fusion transcript, followed by the <i>CBFβ-MHY11</i> and <i>KMT2A</i> rearrangements. <i>FLT3</i>-ITD and <i>KIT</i> mutations are associated with unfavorable clinical features and induction responses, along with <i>KMT2A</i> rearrangements, <i>DEK-NUP214</i>, and CBF-AML. The 5-year event-free survival (EFS) and overall survival (OS) rates of our cohort were 53.9 ± 3.7% and 58.5 ± 3.6%, with the best survival found among patients with <i>CBFβ-MYH11</i> and the worst survival among those with <i>DEK-NUP214</i>. In addition, we found that patients with <i>FLT3</i>-ITD mutation had adverse outcomes and that <i>KIT</i> mutation had a negative impact on OS in <i>RUNX1-RUNX1T1</i><sup>+</sup> patients. Furthermore, the risk classification and response to treatment after each induction block also influenced the prognosis, and HSCT after first remission could improve OS in high-risk patients. Not achieving complete remission after induction 2 was found to be an independent prognostic factor for OS and EFS. These findings indicate that genetic abnormalities could be considered stratification factors, predict patient outcomes, and imply the application of targeted therapy.
DOI: 10.6084/m9.figshare.24906965.v1
title: Prognosis influence of additional chromosome abnormalities in newly diagnosed acute promyelocytic leukemia with t(15;17)(q24;q21)

description: In patients with acute promyelocytic leukemia (APL), additional chromosomal abnormalities (ACAs) are prognostic indicators. However, the clinical features of ACAs were not systematically reported in Chinese patients. Therefore, we enrolled a large cohort of APLs to demonstrate the clinical characteristics and prognostic value of ACAs. 268 patients with newly diagnosed APL with t(15;17)(q24;q21) were retrospectively enrolled, and their clinical characteristics and the predictive value of ACAs were assessed between patients with the presence and absence of ACAs. APL patients with and without ACAs did not differ significantly in their clinical features or treatment response and clinical outcomes like overall survival (OS) and disease-free survival (DFS). It appeared to be substantially associated with worse OS in APL patients with trisomy 8, which was the most common ACA, although DFS was unaffected. Interestingly, the presence of ACAs or trisomy 8 affected OS and DFS in the subgroup of patients aged ≥60 years; by contrast, ACAs had no effect on OS or DFS in any treatment subgroup (ATRA + ATO/RIF or ATRA + ATO/RIF + CH or ATRA + CH), except for the ATRA + ATO/RIF + CH treatment subgroup, where their impact on DFS was less favorable. Our results suggested that OS and DFS were unaffected by ACAs. Nonetheless, in the subgroup of patients older than 60, the existence of ACAs or trisomy 8 appeared to impact OS and DFS negatively. Individuals with t(15;17) alone had a higher DFS and were more susceptible to ATRA + ATO/RIF + CH than individuals with t(15;17) ACAs.
DOI: 10.15468/dl.y6m67q
title: Occurrence Download

description: A dataset containing 44 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Phoca vitulina Linnaeus, 1758",
 "Geometry POLYGON((170 20, 170 50, 120 50, 120 20, 170 20))",
 "HasCoordinate is true"
 ]
}

 The dataset includes 44 records from 2 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0032016-241126133413365/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.5517/ccdc.csd.cc2gv58s
title: CCDC 2289265: Experimental Crystal Structure Determination

description: Related Article: Arne Merschel, Yury V. Vishnevskiy, Beate Neumann, Hans-Georg Stammler, Rajendra S. Ghadwal|2024|Angew.Chem.,Int.Ed.|63|202318525|doi:10.1002/anie.202318525
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.15468/dl.tncb23
title: Occurrence Download

description: A dataset containing 7 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Barbula dixoniana (P.C.Chen) Redf. & B.C.Tan"
 ]
}

 The dataset includes 7 records from 4 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0032017-241126133413365/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.vpgmwj
title: Occurrence Download

description: A dataset containing 8 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Dracula ligiae Luer & R.Escobar"
 ]
}

 The dataset includes 8 records from 5 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0032018-241126133413365/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.qfhzda
title: Occurrence Download

description: A dataset containing 253 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Continent is Asia",
 "Country is one of (Hong Kong, China, Chinese Taipei, Macao)",
 "TaxonKey is Temnothorax Mayr, 1861"
 ]
}

 The dataset includes 253 records from 6 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0032019-241126133413365/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.fxghg9
title: Occurrence Download

description: A dataset containing 325 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Cleisthenes pinetorum Jordan & Starks, 1904",
 "Geometry POLYGON((170 20, 170 50, 120 50, 120 20, 170 20))",
 "HasCoordinate is true"
 ]
}

 The dataset includes 325 records from 13 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0032020-241126133413365/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.k8zyvh
title: Occurrence Download

description: A dataset containing 1717773 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Continent is South America",
 "Country is Colombia",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 "StateProvince is one of (Guaviare, Guaviare Department, Guaviare Dept., Guaviare department, Guaviare State, Meta, MEta, Meta Department, Meta Dept, Meta Dept., Meta Intendencia, Meta Prov, Meta Province, Meta (?), Meta ?)",
 "TaxonKey is Chordata"
 ]
}

 The dataset includes 1717773 records from 246 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0032010-241126133413365/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.5281/zenodo.14418160
title: Proteinoid-Rhodopsin-Based Spiking Neuron

description: Data of potential vs time for paper ''Proteinoid-Rhodopsin-Based Spiking Neuron''.
DOI: 10.5281/zenodo.14418161
title: Proteinoid-Rhodopsin-Based Spiking Neuron

description: Data of potential vs time for paper ''Proteinoid-Rhodopsin-Based Spiking Neuron''.