cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.28776553
title: Dual Task Training Interventions and Mobility-Based Outcomes in Children with Cerebral Palsy: A Scoping Review

description: Children with cerebral palsy (CP) struggle in dual task (DT) situations, where interference may decrease performance when executing two simultaneous tasks. Dual task training (DTT) improves primary motor performance in individuals with typical development and neurological conditions, and emerging research also suggests benefits for DT performance. Its potential in children with CP, however, remains unexplored. This scoping review aims to (1) identify; (2) describe; and (3) synthesize the current evidence for DTT interventions in children with CP, and (4) evaluating its effects on mobility-based impairment, activity, and participation level outcomes. Five electronic databases were searched. Studies were included if they were in English, included children with CP, used a motor-motor or motor-cognitive DTT intervention, detailed the intervention, and reported results. The six studies included 117 children with CP (F: 50, M: 67) and used motor-motor (<i>n</i> = 2) and motor-cognitive (<i>n</i> = 4) DTT paradigms. Training ranged from 480 to 1800 min, and all studies showed improved primary motor task performance. Despite the study heterogeneity, the results provide early, yet promising, evidence that DTT may enhance primary motor task performance in children with CP. Robust and rigorous research is needed to explore the effects of exercise prescription, training regimens, and optimal dosing on motor and cognitive outcomes.
DOI: 10.6084/m9.figshare.28776553.v1
title: Dual Task Training Interventions and Mobility-Based Outcomes in Children with Cerebral Palsy: A Scoping Review

description: Children with cerebral palsy (CP) struggle in dual task (DT) situations, where interference may decrease performance when executing two simultaneous tasks. Dual task training (DTT) improves primary motor performance in individuals with typical development and neurological conditions, and emerging research also suggests benefits for DT performance. Its potential in children with CP, however, remains unexplored. This scoping review aims to (1) identify; (2) describe; and (3) synthesize the current evidence for DTT interventions in children with CP, and (4) evaluating its effects on mobility-based impairment, activity, and participation level outcomes. Five electronic databases were searched. Studies were included if they were in English, included children with CP, used a motor-motor or motor-cognitive DTT intervention, detailed the intervention, and reported results. The six studies included 117 children with CP (F: 50, M: 67) and used motor-motor (<i>n</i> = 2) and motor-cognitive (<i>n</i> = 4) DTT paradigms. Training ranged from 480 to 1800 min, and all studies showed improved primary motor task performance. Despite the study heterogeneity, the results provide early, yet promising, evidence that DTT may enhance primary motor task performance in children with CP. Robust and rigorous research is needed to explore the effects of exercise prescription, training regimens, and optimal dosing on motor and cognitive outcomes.
DOI: 10.6084/m9.figshare.28769023
title: Analysis of Commercial Instagram Content on Pediatric Neurological Physiotherapy Interventions and Products in Brazil

description: To describe the content of commercial pediatric neurological physical therapy posts on Instagram and report the main interventions and products featured. A cross-sectional study was conducted using five pediatric neurological physical therapy hashtags on Brazilian commercial Instagram profiles, on three different days. The initial 50 posts for each hashtag were extracted by two independent reviewers. Data included the source of the posts, content characteristics, target populations, interventions featured in the posts and on the Instagram profiles, as well as the products promoted in the posts. A total of 449 Instagram posts from 190 profiles were analyzed. Most posts were in video format (<i>n</i> = 278; 61.9%), categorized as service reports (<i>n</i> = 203; 45.2%), and posted by autonomous physical therapists (<i>n</i> = 195; 43.4%). The most frequent interventions were Suit therapy (<i>n</i> = 60; 15.9%) and mobility training (<i>n</i> = 59; 15.6%). Cerebral palsy (<i>n</i> = 90; 20%) and Down syndrome (<i>n</i> = 35; 7.7%) were the most frequently represented health conditions. Instagram offers various interventions and products for pediatric neurological rehabilitation. Excess information may cause indecision and adherence to ineffective treatments by families. Future research should assess the evidence behind services on social media and their impact on parents’ decision-making.
DOI: 10.6084/m9.figshare.28769023.v1
title: Analysis of Commercial Instagram Content on Pediatric Neurological Physiotherapy Interventions and Products in Brazil

description: To describe the content of commercial pediatric neurological physical therapy posts on Instagram and report the main interventions and products featured. A cross-sectional study was conducted using five pediatric neurological physical therapy hashtags on Brazilian commercial Instagram profiles, on three different days. The initial 50 posts for each hashtag were extracted by two independent reviewers. Data included the source of the posts, content characteristics, target populations, interventions featured in the posts and on the Instagram profiles, as well as the products promoted in the posts. A total of 449 Instagram posts from 190 profiles were analyzed. Most posts were in video format (<i>n</i> = 278; 61.9%), categorized as service reports (<i>n</i> = 203; 45.2%), and posted by autonomous physical therapists (<i>n</i> = 195; 43.4%). The most frequent interventions were Suit therapy (<i>n</i> = 60; 15.9%) and mobility training (<i>n</i> = 59; 15.6%). Cerebral palsy (<i>n</i> = 90; 20%) and Down syndrome (<i>n</i> = 35; 7.7%) were the most frequently represented health conditions. Instagram offers various interventions and products for pediatric neurological rehabilitation. Excess information may cause indecision and adherence to ineffective treatments by families. Future research should assess the evidence behind services on social media and their impact on parents’ decision-making.
DOI: 10.6084/m9.figshare.28578276
title: Data Reproducibility of Spin-Echo Small-Angle Neutron Scattering Instruments

description: Data Reproducibility of Spin-Echo Small-Angle Neutron Scattering Instruments
DOI: 10.6084/m9.figshare.28578276.v1
title: Data Reproducibility of Spin-Echo Small-Angle Neutron Scattering Instruments

description: Data Reproducibility of Spin-Echo Small-Angle Neutron Scattering Instruments
DOI: 10.6084/m9.figshare.31112091
title: Analysis of private sector interest in blue green infrastructure by the Motivation and Abilities (MOTA) framework: a case study in Ho Chi Minh City, Vietnam

description: Blue Green Infrastructure is an emerging approach to storm water management in Ho Chi Minh City, helping to mitigate the negative effects of excess stormwater while providing multiple benefits. While several top-down initiatives for better stormwater management practices have been proposed, many enterprises fail to implement or do not perform as expected. There is also a lack of private sector participation in stormwater management, where policy and clear regulation is lacking. This paper identifies the primary factors contributing to private sector participation in Blue Green Infrastructure projects in Ho Chi Minh City and validates them through a survey of construction specialists, experts from local authorities, and residents. A Motivation and Abilities (MOTA) framework analysis reveals that primary risk factors are a lack of perceived economic and financial benefits and maintenance concerns. The primary motivational factors, in turn, are improved public relations, improved selling value, and an increased Floor-Area Ratio.
DOI: 10.6084/m9.figshare.31112091.v1
title: Analysis of private sector interest in blue green infrastructure by the Motivation and Abilities (MOTA) framework: a case study in Ho Chi Minh City, Vietnam

description: Blue Green Infrastructure is an emerging approach to storm water management in Ho Chi Minh City, helping to mitigate the negative effects of excess stormwater while providing multiple benefits. While several top-down initiatives for better stormwater management practices have been proposed, many enterprises fail to implement or do not perform as expected. There is also a lack of private sector participation in stormwater management, where policy and clear regulation is lacking. This paper identifies the primary factors contributing to private sector participation in Blue Green Infrastructure projects in Ho Chi Minh City and validates them through a survey of construction specialists, experts from local authorities, and residents. A Motivation and Abilities (MOTA) framework analysis reveals that primary risk factors are a lack of perceived economic and financial benefits and maintenance concerns. The primary motivational factors, in turn, are improved public relations, improved selling value, and an increased Floor-Area Ratio.
DOI: 10.15468/dl.qps96d
title: Occurrence Download

description: A dataset containing 110471 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Morone americana, Oxyura maccoa, Oxyura vittata, Poecilia latipinna, Procambarus alleni, Rana aurora, Sagittaria platyphylla, Sagittaria subulata, Salvinia minima, Silurus asotus, Tarebia granifera, Trachemys ornata, Tridentiger bifasciatus, Xiphophorus hellerii)",
 "BasisOfRecord is one of (Observation, Human Observation, Material sample, Specimen, Machine Observation, Occurrence evidence)",
 "Year is greater than or equal to 1971",
 "Year is less than or equal to 2025",
 "HasCoordinate is true",
 "OccurrenceStatus is Present",
 "HasGeospatialIssue is false",
 {
 "or" : [
 "CoordinateUncertaintyInMeters is less than or equal to 5000",
 "CoordinateUncertaintyInMeters is null"
 ]
 }
 ]
}

 The dataset includes 110471 records from 466 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0002279-260120142942310/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.6084/m9.figshare.28730901
title: Discovery of <i>bis</i>-chalcones and <i>bis</i>-pyrimidines as potential urease inhibitors: from synthesis to computational insights

description: This study focuses on the design and evaluation of <i>bis</i>-chalcones and <i>bis</i>-pyrimidines as potential urease inhibitors. A series of <i>bis</i>-chalcone and <i>bis</i>-pyrimidine derivatives were synthesized and assessed for their <i>in vitro</i> urease inhibitory activity. Kinetic studies were conducted using Lineweaver–Burk plots to determine the inhibition mechanism of the most potent compound. Molecular docking was employed to investigate the binding interactions with the urease active site, followed by MD simulations to validate complex stability. Computational ADMET analysis was performed to assess the drug-like properties of the most active inhibitor. Several synthesized compounds exhibited potent urease inhibitory activity, significantly surpassing the standard inhibitor thiourea. The most active compound, 8P, displayed noncompetitive inhibition, as confirmed by kinetic studies. SAR analysis revealed that electron-withdrawing substituents enhanced inhibitory potency. Molecular docking studies demonstrated favorable interactions between inhibitors and key urease residues, while MD simulations confirmed complex stability. ADMET analysis supported the drug-like potential of 8P. This study provides valuable insights into the development of target compounds as promising urease inhibitors. These findings suggest their potential therapeutic applications for urease-related disorders.
DOI: 10.6084/m9.figshare.28730901.v1
title: Discovery of <i>bis</i>-chalcones and <i>bis</i>-pyrimidines as potential urease inhibitors: from synthesis to computational insights

description: This study focuses on the design and evaluation of <i>bis</i>-chalcones and <i>bis</i>-pyrimidines as potential urease inhibitors. A series of <i>bis</i>-chalcone and <i>bis</i>-pyrimidine derivatives were synthesized and assessed for their <i>in vitro</i> urease inhibitory activity. Kinetic studies were conducted using Lineweaver–Burk plots to determine the inhibition mechanism of the most potent compound. Molecular docking was employed to investigate the binding interactions with the urease active site, followed by MD simulations to validate complex stability. Computational ADMET analysis was performed to assess the drug-like properties of the most active inhibitor. Several synthesized compounds exhibited potent urease inhibitory activity, significantly surpassing the standard inhibitor thiourea. The most active compound, 8P, displayed noncompetitive inhibition, as confirmed by kinetic studies. SAR analysis revealed that electron-withdrawing substituents enhanced inhibitory potency. Molecular docking studies demonstrated favorable interactions between inhibitors and key urease residues, while MD simulations confirmed complex stability. ADMET analysis supported the drug-like potential of 8P. This study provides valuable insights into the development of target compounds as promising urease inhibitors. These findings suggest their potential therapeutic applications for urease-related disorders.
DOI: 10.6084/m9.figshare.31112097
title: Integrating Street Food into Intangible Cultural Heritage: Emerging Role of Digital Heritage Preservation and Technology Integration

description: This study examines the systemic factors behind this exclusion and suggests a technologically driven pathway to achieve recognition. Using a PRISMA-guided review of 34 articles, our thematic analysis identifies a core “polycentric failure mode” and four interconnected contradictions related to documentation, commercialization, equity, and ecology, which create insurmountable barriers for informal traditions seeking formal Intangible Cultural Heritage (ICH) status. We contend that community-led digital preservation provides a direct solution. By employing tools such as blockchain archives and AI-driven documentation, communities can meet UNESCO’s strict evidentiary standards. This approach transforms dynamic, informal practices into structured, verifiable heritage data without imposing disruptive formalization. This research proposes a new policy model that bridges the gap between institutional frameworks and living heritage, ensuring the protection of vital cultural practices in the digital era.
DOI: 10.6084/m9.figshare.31112097.v1
title: Integrating Street Food into Intangible Cultural Heritage: Emerging Role of Digital Heritage Preservation and Technology Integration

description: This study examines the systemic factors behind this exclusion and suggests a technologically driven pathway to achieve recognition. Using a PRISMA-guided review of 34 articles, our thematic analysis identifies a core “polycentric failure mode” and four interconnected contradictions related to documentation, commercialization, equity, and ecology, which create insurmountable barriers for informal traditions seeking formal Intangible Cultural Heritage (ICH) status. We contend that community-led digital preservation provides a direct solution. By employing tools such as blockchain archives and AI-driven documentation, communities can meet UNESCO’s strict evidentiary standards. This approach transforms dynamic, informal practices into structured, verifiable heritage data without imposing disruptive formalization. This research proposes a new policy model that bridges the gap between institutional frameworks and living heritage, ensuring the protection of vital cultural practices in the digital era.
DOI: 10.6084/m9.figshare.28891320.v1
title: Impact of apathy over the course of disease in amyotrophic lateral sclerosis

description: <i>Objective</i>: Apathy is a common syndrome in amyotrophic lateral sclerosis (ALS), particularly Initiation apathy (lack of motivation for self-generated thoughts and/or actions). The aim was to determine how apathy subtypes change over time, and their impact on individuals’ quality of life (QoL), caregiver-wellbeing and burden or strain. <i>Methods</i>: Forty-nine people living with ALS (pwALS) and their caregiver participated in interviews at three time-points (3-month intervals). They completed the Dimensional Apathy Scale (DAS), and assessments of depression, anxiety and emotional lability, cognitive-behavioral functioning and functional disability. PwALS QoL, caregiver burden or strain, caregiver-wellbeing and care-related QoL were measured. <i>Results</i>: At baseline, Initiation apathy was most common (38.8%, <i>N</i> = 19) followed by Emotional apathy (16.3%, <i>N</i> = 8). Lower caregiver-wellbeing was observed in Initiation apathy (<i>p</i> &lt; 0.05) and Mixed-emotional apathy (<i>p</i> &lt; 0.001) groups, where only Initiation apathy had higher caregiver burden or strain (<i>p</i> &lt; 0.05) than those with no apathy. Over three visits (<i>N</i> = 31), there was an increase in Initiation apathy (<i>p</i> &lt; 0.01) and Executive apathy (<i>p</i> &lt; 0.05) over time. While controlling for functional disability, only increasing Emotional apathy was associated with increasing caregiver burden or strain (<i>p</i> &lt; 0.05), decreasing caregiver-wellbeing (<i>p</i> &lt; 0.001), and decreasing care-related QoL (<i>p</i> &lt; 0.05). <i>Conclusion</i>: Initiation and Emotional apathy were variably associated with higher levels of caregiver burden or strain and decreased caregiver-wellbeing in ALS. As ALS progresses, Initiation and Executive apathy increased, while Emotional apathy has been shown to impact care-related QoL, caregiver-wellbeing and burden or strain. This has implications for understanding the progression of apathy subtypes and the interplay of caregiver-wellbeing, QoL, burden, or strain.
DOI: 10.6084/m9.figshare.28517695
title: Persistent high levels of perceived fatigue are not associated with hypermetabolism in patients with amyotrophic lateral sclerosis

description: <i>Objective</i>: Fatigue is a common symptom in amyotrophic lateral sclerosis (ALS). Little is known about factors that contribute to fatigue, and whether levels of fatigue change throughout disease course. We aimed to determine associations between self-reported perceived fatigue and metabolic and clinical features of ALS, and perceived fatigue over the course of disease. <i>Methods</i>: This prospective study was conducted between July 2017 and March 2024. Baseline measures of self-reported perceived fatigue, metabolic rate, and clinical measures of disease were assessed in 117 participants with clinically definite or probable ALS. For comparison, fatigue and metabolic rate were collected from 107 control participants. Perceived fatigue was determined using the Fatigue Severity Scale (FSS). Metabolic rate was assessed using indirect calorimetry. Functional capacity and clinical progression were assessed using the ALS Functional Rating Scale-Revised (ALSFRS-R). <i>Results</i>: Baseline levels of perceived fatigue were greater in people living with ALS (plwALS) when compared to controls (5.44 vs. 2.55; <i>p</i> &lt; 0.01). Perceived fatigue was higher in plwALS with lower ALSFRS-R scores and was not associated with measures of metabolism. For most plwALS, perceived fatigue remained high as functional capacity worsened. <i>Conclusion</i>: Our findings confirm higher prevalence of perceived fatigue in plwALS, with persistently high FSS scores reported by most patients during follow-up. High levels of fatigue were not associated with hypermetabolism, suggesting that metabolic rate is unlikely to be a primary contributor. Results highlight a need for further research to identify factors that contribute to fatigue in ALS, and options for improved fatigue management.
DOI: 10.6084/m9.figshare.28517695.v1
title: Persistent high levels of perceived fatigue are not associated with hypermetabolism in patients with amyotrophic lateral sclerosis

description: <i>Objective</i>: Fatigue is a common symptom in amyotrophic lateral sclerosis (ALS). Little is known about factors that contribute to fatigue, and whether levels of fatigue change throughout disease course. We aimed to determine associations between self-reported perceived fatigue and metabolic and clinical features of ALS, and perceived fatigue over the course of disease. <i>Methods</i>: This prospective study was conducted between July 2017 and March 2024. Baseline measures of self-reported perceived fatigue, metabolic rate, and clinical measures of disease were assessed in 117 participants with clinically definite or probable ALS. For comparison, fatigue and metabolic rate were collected from 107 control participants. Perceived fatigue was determined using the Fatigue Severity Scale (FSS). Metabolic rate was assessed using indirect calorimetry. Functional capacity and clinical progression were assessed using the ALS Functional Rating Scale-Revised (ALSFRS-R). <i>Results</i>: Baseline levels of perceived fatigue were greater in people living with ALS (plwALS) when compared to controls (5.44 vs. 2.55; <i>p</i> &lt; 0.01). Perceived fatigue was higher in plwALS with lower ALSFRS-R scores and was not associated with measures of metabolism. For most plwALS, perceived fatigue remained high as functional capacity worsened. <i>Conclusion</i>: Our findings confirm higher prevalence of perceived fatigue in plwALS, with persistently high FSS scores reported by most patients during follow-up. High levels of fatigue were not associated with hypermetabolism, suggesting that metabolic rate is unlikely to be a primary contributor. Results highlight a need for further research to identify factors that contribute to fatigue in ALS, and options for improved fatigue management.
DOI: 10.6084/m9.figshare.28891320
title: Impact of apathy over the course of disease in amyotrophic lateral sclerosis

description: <i>Objective</i>: Apathy is a common syndrome in amyotrophic lateral sclerosis (ALS), particularly Initiation apathy (lack of motivation for self-generated thoughts and/or actions). The aim was to determine how apathy subtypes change over time, and their impact on individuals’ quality of life (QoL), caregiver-wellbeing and burden or strain. <i>Methods</i>: Forty-nine people living with ALS (pwALS) and their caregiver participated in interviews at three time-points (3-month intervals). They completed the Dimensional Apathy Scale (DAS), and assessments of depression, anxiety and emotional lability, cognitive-behavioral functioning and functional disability. PwALS QoL, caregiver burden or strain, caregiver-wellbeing and care-related QoL were measured. <i>Results</i>: At baseline, Initiation apathy was most common (38.8%, <i>N</i> = 19) followed by Emotional apathy (16.3%, <i>N</i> = 8). Lower caregiver-wellbeing was observed in Initiation apathy (<i>p</i> &lt; 0.05) and Mixed-emotional apathy (<i>p</i> &lt; 0.001) groups, where only Initiation apathy had higher caregiver burden or strain (<i>p</i> &lt; 0.05) than those with no apathy. Over three visits (<i>N</i> = 31), there was an increase in Initiation apathy (<i>p</i> &lt; 0.01) and Executive apathy (<i>p</i> &lt; 0.05) over time. While controlling for functional disability, only increasing Emotional apathy was associated with increasing caregiver burden or strain (<i>p</i> &lt; 0.05), decreasing caregiver-wellbeing (<i>p</i> &lt; 0.001), and decreasing care-related QoL (<i>p</i> &lt; 0.05). <i>Conclusion</i>: Initiation and Emotional apathy were variably associated with higher levels of caregiver burden or strain and decreased caregiver-wellbeing in ALS. As ALS progresses, Initiation and Executive apathy increased, while Emotional apathy has been shown to impact care-related QoL, caregiver-wellbeing and burden or strain. This has implications for understanding the progression of apathy subtypes and the interplay of caregiver-wellbeing, QoL, burden, or strain.