cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.5281/zenodo.17206336
title: Multiscale simulations reveal dynamics interfacial network and membrane remodeling of the ankyrin-1 complex

description: This dataset contains representative molecular dynamics (MD) trajectory segments and their corresponding topology files from the study. All files have been preprocessed to remove solvent molecules (and lipids for all-atom data), enabling efficient visualization and analysis.

The dataset consists of three parts:

All-atom simulations – (1) one unbiased 2 μs production trajectory, (2) four independent 2 ns trajectories used for binding free energy calculations, (3) one em.gro and (4) one rmsd_ref.gro.

Coarse-grained simulations – four 2-μs production trajectories: (1) full ankyrin-1 complex, (2) membrane-only control, (3) full complex including the ankyrin-1 subunit, and (4) truncated complex excluding the ankyrin-1 subunit.

Topology files – complete topology files required to reproduce and analyze the simulations.

These subsets capture the key interfacial interactions and membrane remodeling patterns described in the study, while significantly reducing file size for convenient download. The full trajectories are available from the corresponding author upon reasonable request.
DOI: 10.15468/dl.bntmeh
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Ambrosia polystachya",
 "Country is Mauritius",
 "HasCoordinate is true"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0018721-250920141307145/datasets/export for details.
DOI: 10.15468/dl.brj4jp
title: Occurrence Download

description: A dataset containing 25 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Sesarmops impressus",
 "Geometry POLYGON((119.300000 20.500000, 122.100000 20.500000, 122.100000 25.400000, 119.300000 25.400000, 119.300000 20.500000))",
 "HasCoordinate is true",
 "HasGeospatialIssue is false"
 ]
}

 The dataset includes 25 records from 3 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0018722-250920141307145/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.5281/zenodo.15850536
title: pop-cosmos: Galaxy property and redshift catalog for COSMOS2020

description: This record (v≥2.0.0) contains data products associated with the paper "pop-cosmos: Insights from generative modeling of a deep, infrared-selected galaxy population" by Thorp et al. (2025). Earlier versions of this record (v<2.0.0) contain data products associated with the paper "pop-cosmos: Scaleable inference of galaxy properties and redshifts with a data-driven population model" by Thorp et al. (2024), which are superseded by the contents of v2.0.0. In v≥2.0.0, we include results for all COSMOS2020 galaxies with $\textit{Ch.1}<26$ or $r<25$.

The included products are derived from spectral energy distribution (SED) fits to 26-band COSMOS2020 photometry, using the 16-parameter SPS model described in Thorp et al. (2024, 2025), and the pop-cosmos prior from Thorp et al. (2025). All results are based on Markov Chain Monte Carlo (MCMC) runs using the configuration described in Thorp et al. (2024, 2025). Results correspond to v2.1 of the COSMOS2020 catalog.

The current release includes the following files:



README_v2_1_0.txt: Detailed information about how to read the other files in the record.

mcmc_summaries.h5.gz: Zipped HDF5 file with summaries (percentiles) of the posteriors.

mcmc_samples_pop_cosmos.h5.gz: Zipped HDF5 file with posterior samples (using pop-cosmos prior).

mcmc_samples_Prospector.h5.gz: Zipped HDF5 file with posterior samples (using Prospector-$\alpha$ prior).


If you make use of any of these products, please cite this repository and Thorp et al. (2024, 2025). Please also cite the pop-cosmos overview paper by Alsing et al. (2024). If you make use of any COSMOS data products, please cite Weaver et al. (2022) and any other relevant publications. If you make use of COSMOS spectroscopic data, please cite Khostovan et al. (2025) and references therein.

If you spot any issues or have any requests, please contact the corresponding author (Stephen Thorp) using the details in the README.

If you want to access pop-cosmos mock galaxy catalogs, these can be found on Zenodo.

Related software, including a demo notebook for working with the data in this record, can be found on GitHub. 

References:



Alsing et al. (2024). ApJS 274, 12. [arXiv:2402.00935][doi]

Khostovan et al. (2025). ApJ, submitted. [arXiv:2503.00120]

Thorp et al. (2024). ApJ 975, 145. [arXiv:2406.19437][doi]

Thorp et al. (2025). ApJ, accepted. [arXiv:2506.12122]

Weaver et al. (2022). ApJS 258, 11. [arXiv:2110.13923][doi]
DOI: 10.15468/dl.qccgzz
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Ambrosia polystachya",
 "Country is Paraguay",
 "HasCoordinate is true"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0018725-250920141307145/datasets/export for details.
DOI: 10.15468/dl.x2k4bp
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Ambrosia polystachya",
 "Country is Peru",
 "HasCoordinate is true"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0018726-250920141307145/datasets/export for details.
DOI: 10.23669/1ztelp/eskrhu
title: cda1055_dat_ParlaCAP-UA_speeches.tsv.zip

description: :unav
DOI: 10.23669/1ztelp/siaarm
title: cda1055_dat_ParlaCAP-ES-PV_speeches.tsv.zip

description: :unav
DOI: 10.23669/1ztelp/tu9hpi
title: cda1055_dat_ParlaCAP-TR_speeches.tsv.zip

description: :unav
DOI: 10.23669/1ztelp/mgcde5
title: cda1055_dat_ParlaCAP-HR_speeches.tsv.zip

description: :unav
DOI: 10.23669/1ztelp/ug1xwh
title: cda1055_dat_ParlaCAP-RS_speeches.tsv.zip

description: :unav
DOI: 10.23669/1ztelp/oxkxzg
title: cda1055_dat_ParlaCAP-GR_speeches.tsv.zip

description: :unav
DOI: 10.17026/ar/hsvbw8
title: PAN-00143872 - iron nail general

description: &lt;p&gt;This find is registered at Portable Antiquities of the Netherlands with number PAN-00143872&lt;/p&gt;
description: Modified: 2025-07-17T10:55:28+02:00
DOI: 10.23669/1ztelp/mwkbtm
title: cda1055_dat_ParlaCAP-IT_speeches.tsv.zip

description: :unav
DOI: 10.15468/dl.qg4pq8
title: Occurrence Download

description: A dataset containing 17 species occurrences available in GBIF matching the query:
{
 "and" : [
 "BasisOfRecord is one of (Observation, Human Observation)",
 "DatasetKey is iNaturalist Research-grade Observations",
 "Geometry POLYGON((-69.8752 12.42661,-69.87087 12.41948,-69.86615 12.42155,-69.87162 12.43601,-69.87221 12.43761,-69.87221 12.43761,-69.87722 12.43501,-69.87669 12.43362,-69.8752 12.42661))",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present"
 ]
}

 The dataset includes 17 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0018728-250920141307145/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.23669/1ztelp/ls12gf
title: cda1055_dat_ParlaCAP-AT_speeches.tsv.zip

description: :unav
DOI: 10.23669/1ztelp/zrdc6n
title: cda1055_dat_ParlaCAP-EE_speeches.tsv.zip

description: :unav
DOI: 10.23669/1ztelp/hqtrbp
title: cda1055_dat_ParlaCAP-ES-GA_speeches.tsv.zip

description: :unav
DOI: 10.23669/1ztelp/piixlt
title: cda1055_dat_ParlaCAP-ES-CT_speeches.tsv.zip

description: :unav
DOI: 10.15468/dl.3yrxzk
title: Occurrence Download

description: A dataset containing 32330 species occurrences available in GBIF matching the query:
{
 "and" : [
 {
 "and" : [
 "HasGeospatialIssue is false",
 "HasCoordinate is true",
 "OccurrenceStatus is Present",
 {
 "not" : {
 "BasisOfRecord" : [
 "is one of (Fossil, Living Specimen)"
 ]
 }
 }
 ]
 },
 "TaxonKey is one of (Chenopodium bonus-henricus)"
 ]
}

 The dataset includes 32330 records from 323 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0018723-250920141307145/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.23669/1ztelp/s6bplq
title: cda1055_dat_ParlaCAP-LV_speeches.tsv.zip

description: :unav
DOI: 10.23669/1ztelp/ulpfvt
title: cda1055_dat_ParlaCAP-BG_speeches.tsv.zip

description: :unav
DOI: 10.23669/1ztelp/ad4suj
title: cda1055_dat_ParlaCAP-SE_speeches.tsv.zip

description: :unav
DOI: 10.23669/1ztelp/0xzb8s
title: cda1055_dat_ParlaCAP-PL_speeches.tsv.zip

description: :unav
DOI: 10.23669/1ztelp/trb27p
title: cda1055_dat_ParlaCAP-FR_speeches.tsv.zip

description: :unav
DOI: 10.23669/1ztelp/40ujdh
title: cda1055_dat_ParlaCAP-IS_speeches.tsv.zip

description: :unav
DOI: 10.23669/1ztelp/oalzxw
title: cda1055_dat_ParlaCAP-HU_speeches.tsv.zip

description: :unav
DOI: 10.23669/1ztelp/01qg6q
title: cda1055_dat_ParlaCAP-GB_speeches.tsv.zip

description: :unav
DOI: 10.17026/ar/ngkqts
title: PAN-00130692 - eye brooch

description: &lt;p&gt;This find is registered at Portable Antiquities of the Netherlands with number PAN-00130692&lt;/p&gt;
description: Modified: 2025-04-29T11:59:50+02:00
DOI: 10.23669/1ztelp/evlfdp
title: cda1055_dat_ParlaCAP-BE_speeches.tsv.zip

description: :unav
DOI: 10.23669/1ztelp/1kqhm5
title: cda1055_dat_ParlaCAP-NO_speeches.tsv.zip

description: :unav
DOI: 10.23669/1ztelp/rthqpv
title: cda1055_dat_ParlaCAP-NL_speeches.tsv.zip

description: :unav
DOI: 10.23669/1ztelp/jsgjrn
title: cda1055_dat_ParlaCAP-DK_speeches.tsv.zip

description: :unav
DOI: 10.23669/1ztelp/9sbwyl
title: cda1055_dat_ParlaCAP-ES_speeches.tsv.zip

description: :unav
DOI: 10.23669/1ztelp/cpvjty
title: cda1055_dat_ParlaCAP-PT_speeches.tsv.zip

description: :unav
DOI: 10.23669/1ztelp/qsae15
title: cda1055_dat_ParlaCAP-CZ_speeches.tsv.zip

description: :unav
DOI: 10.23669/1ztelp/pxujuk
title: cda1055_dat_ParlaCAP-SI_speeches.tsv.zip

description: :unav
DOI: 10.23669/1ztelp/m86juc
title: cda1055_dat_ParlaCAP-BA_speeches.tsv.zip

description: :unav
DOI: 10.23669/1ztelp/7kpt27
title: cda1055_dat_ParlaCAP-PL_speeches_no_text.tsv.zip

description: :unav
DOI: 10.23669/1ztelp/3lde1a
title: cda1055_dat_ParlaCAP-ES-GA_speeches_no_text.tsv.zip

description: :unav
DOI: 10.23669/1ztelp/8aa3ki
title: cda1055_dat_ParlaCAP-NO_speeches_no_text.tsv.zip

description: :unav
DOI: 10.23669/1ztelp/7ryuqn
title: cda1055_dat_ParlaCAP-UA_speeches_no_text.tsv.zip

description: :unav
DOI: 10.23669/1ztelp/1mfgnr
title: cda1055_dat_ParlaCAP-BA_speeches_no_text.tsv.zip

description: :unav
DOI: 10.23669/1ztelp/sh6a1b
title: cda1055_dat_ParlaCAP-CZ_speeches_no_text.tsv.zip

description: :unav
DOI: 10.23669/1ztelp/w8i8a5
title: cda1055_dat_ParlaCAP-HR_speeches_no_text.tsv.zip

description: :unav
DOI: 10.17026/ar/gtzqqk
title: PAN-00042634 - coin/coin-related, Maximiliaan van Bronckhorst (1612-1641), duit

description: &lt;p&gt;This find is registered at Portable Antiquities of the Netherlands with number PAN-00042634&lt;/p&gt;
description: Modified: 2025-07-15T10:41:49+02:00
DOI: 10.23669/1ztelp/wo6kzs
title: cda1055_dat_ParlaCAP-NL_speeches_no_text.tsv.zip

description: :unav
DOI: 10.23669/1ztelp/2t1qwb
title: cda1055_dat_ParlaCAP-IS_speeches_no_text.tsv.zip

description: :unav
DOI: 10.23669/1ztelp/jzjhmm
title: cda1055_dat_ParlaCAP-AT_speeches_no_text.tsv.zip

description: :unav
DOI: 10.23669/1ztelp/2peqzg
title: cda1055_dat_ParlaCAP-PT_speeches_no_text.tsv.zip

description: :unav
DOI: 10.23669/1ztelp/aei4e3
title: cda1055_dat_ParlaCAP-ES-CT_speeches_no_text.tsv.zip

description: :unav
DOI: 10.23669/1ztelp/kwix5t
title: cda1055_dat_ParlaCAP-SI_speeches_no_text.tsv.zip

description: :unav
DOI: 10.5281/zenodo.17206517
title: Literature on the Impact of dust and associated metal content on phytoplankton

description: This document consists of two datasets: (1) Table 1 Dust loads and (2) Table 2 Metal Content. The first table provides an overview of previously published work on the impact of dust loads on marine phytoplankton from various regions, while the second table describes the effect of metal content, as determined from dust, on phytoplankton. The location of the phytoplankton collected and the dust utilised during the experiments is described, as well as the effect on phytoplankton groups/ species. The references for each table are noted in a separate sheet.
DOI: 10.23669/1ztelp/g7ilib
title: cda1055_dat_ParlaCAP-GB_speeches_no_text.tsv.zip

description: :unav
DOI: 10.5281/zenodo.17206516
title: Literature on the Impact of dust and associated metal content on phytoplankton

description: This document consists of two datasets: (1) Table 1 Dust loads and (2) Table 2 Metal Content. The first table provides an overview of previously published work on the impact of dust loads on marine phytoplankton from various regions, while the second table describes the effect of metal content, as determined from dust, on phytoplankton. The location of the phytoplankton collected and the dust utilised during the experiments is described, as well as the effect on phytoplankton groups/ species. The references for each table are noted in a separate sheet.
DOI: 10.23669/1ztelp/akipkk
title: cda1055_dat_ParlaCAP-EE_speeches_no_text.tsv.zip

description: :unav
DOI: 10.23669/1ztelp/vrgd48
title: cda1055_dat_ParlaCAP-BG_speeches_no_text.tsv.zip

description: :unav
DOI: 10.23669/1ztelp/0to7dg
title: cda1055_dat_ParlaCAP-LV_speeches_no_text.tsv.zip

description: :unav
DOI: 10.23669/1ztelp/qtjts4
title: cda1055_dat_ParlaCAP-ES_speeches_no_text.tsv.zip

description: :unav
DOI: 10.23669/1ztelp/qrnk4f
title: cda1055_dat_ParlaCAP-GR_speeches_no_text.tsv.zip

description: :unav
DOI: 10.23669/1ztelp/noq6u6
title: cda1055_dat_ParlaCAP-SE_speeches_no_text.tsv.zip

description: :unav
DOI: 10.23669/1ztelp/a1tgq3
title: cda1055_dat_ParlaCAP-TR_speeches_no_text.tsv.zip

description: :unav
DOI: 10.23669/1ztelp/7uwa9n
title: cda1055_dat_ParlaCAP-BE_speeches_no_text.tsv.zip

description: :unav
DOI: 10.23669/1ztelp/2gdmbm
title: cda1055_dat_ParlaCAP-DK_speeches_no_text.tsv.zip

description: :unav
DOI: 10.23669/1ztelp/btbt3d
title: cda1055_dat_ParlaCAP-ES-PV_speeches_no_text.tsv.zip

description: :unav
DOI: 10.23669/1ztelp/twtlmp
title: cda1055_dat_ParlaCAP-FR_speeches_no_text.tsv.zip

description: :unav
DOI: 10.23669/1ztelp/ugbkcc
title: cda1055_dat_ParlaCAP-IT_speeches_no_text.tsv.zip

description: :unav
DOI: 10.15468/dl.f6ff26
title: Occurrence Download

description: A dataset containing 8 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Kempina mikado",
 "Geometry POLYGON((119.300000 20.500000, 122.100000 20.500000, 122.100000 25.400000, 119.300000 25.400000, 119.300000 20.500000))",
 "HasCoordinate is true",
 "HasGeospatialIssue is false"
 ]
}

 The dataset includes 8 records from 3 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0018729-250920141307145/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.23669/1ztelp/kt4nxb
title: cda1055_dat_ParlaCAP-HU_speeches_no_text.tsv.zip

description: :unav
DOI: 10.23669/1ztelp/a824wp
title: cda1055_dat_ParlaCAP-RS_speeches_no_text.tsv.zip

description: :unav
DOI: 10.23669/1ztelp/gxblct
title: cda1055_dat_ParlaCAP-BE_sentences.tsv.zip

description: :unav
DOI: 10.23669/1ztelp/svno9h
title: cda1055_dat_ParlaCAP-GR_sentences.tsv.zip

description: :unav
DOI: 10.23669/1ztelp/lmepto
title: cda1055_dat_ParlaCAP-ES-CT_sentences.tsv.zip

description: :unav
DOI: 10.23669/1ztelp/zhnyvl
title: cda1055_dat_ParlaCAP-ES-GA_sentences.tsv.zip

description: :unav
DOI: 10.23669/1ztelp/8pv9wv
title: cda1055_dat_ParlaCAP-FR_sentences.tsv.zip

description: :unav
DOI: 10.23669/1ztelp/j26gzn
title: cda1055_dat_ParlaCAP-PT_sentences.tsv.zip

description: :unav
DOI: 10.17026/ar/e57w5r
title: PAN-00171235 - Late Medieval/early modern signet/flat face ring

description: &lt;p&gt;This find is registered at Portable Antiquities of the Netherlands with number PAN-00171235&lt;/p&gt;
description: Modified: 2025-04-30T12:36:10+02:00
DOI: 10.23669/1ztelp/nl9ups
title: cda1055_dat_ParlaCAP-DK_sentences.tsv.zip

description: :unav
DOI: 10.23669/1ztelp/xrufjd
title: cda1055_dat_ParlaCAP-BA_sentences.tsv.zip

description: :unav
DOI: 10.23669/1ztelp/bwelcv
title: cda1055_dat_ParlaCAP-AT_sentences.tsv.zip

description: :unav
DOI: 10.23669/1ztelp/2klach
title: cda1055_dat_ParlaCAP-UA_sentences.tsv.zip

description: :unav
DOI: 10.23669/1ztelp/uqw6nd
title: cda1055_dat_ParlaCAP-HR_sentences.tsv.zip

description: :unav
DOI: 10.23669/1ztelp/h6qbbr
title: cda1055_dat_ParlaCAP-RS_sentences.tsv.zip

description: :unav
DOI: 10.23669/1ztelp/0u8jtq
title: cda1055_dat_ParlaCAP-ES_sentences.tsv.zip

description: :unav
DOI: 10.23669/1ztelp/nwcor4
title: cda1055_dat_ParlaCAP-HU_sentences.tsv.zip

description: :unav
DOI: 10.23669/1ztelp/j2vrop
title: cda1055_dat_ParlaCAP-LV_sentences.tsv.zip

description: :unav
DOI: 10.23669/1ztelp/rjzedq
title: cda1055_dat_ParlaCAP-GB_sentences.tsv.zip

description: :unav
DOI: 10.23669/1ztelp/vwhglw
title: cda1055_dat_ParlaCAP-NL_sentences.tsv.zip

description: :unav
DOI: 10.23669/1ztelp/idq8nr
title: cda1055_dat_ParlaCAP-ES-PV_sentences.tsv.zip

description: :unav
DOI: 10.23669/1ztelp/gsgfyk
title: cda1055_dat_ParlaCAP-SE_sentences.tsv.zip

description: :unav
DOI: 10.23669/1ztelp/c3lyuu
title: cda1055_dat_ParlaCAP-BG_sentences.tsv.zip

description: :unav
DOI: 10.23669/1ztelp/ectipw
title: cda1055_dat_ParlaCAP-IS_sentences.tsv.zip

description: :unav
DOI: 10.23669/1ztelp/hbhqs6
title: cda1055_dat_ParlaCAP-EE_sentences.tsv.zip

description: :unav
DOI: 10.17026/ar/18uo0k
title: PAN-00108219 - finger ring of all-around braided wires/bands (late medieval/modern period

description: &lt;p&gt;This find is registered at Portable Antiquities of the Netherlands with number PAN-00108219&lt;/p&gt;
description: Modified: 2025-04-30T15:12:22+02:00
DOI: 10.23669/1ztelp/2lwzmj
title: cda1055_dat_ParlaCAP-TR_sentences.tsv.zip

description: :unav
DOI: 10.6084/m9.figshare.28639523
title: Neutrophil Extracellular Trap-borne C3-Driven Endothelial Dysfunction in Klebsiella pneumoniae Liver Abscess

description: Klebsiella pneumoniae (K. pneumoniae) liver abscess (KPLA) is a severe bacterial infection that is frequently complicated by intrahepatic thrombophlebitis and extrahepatic metastatic infections leading to high mortality rates. This study investigates the role of neutrophil extracellular traps (NETs) in endothelial injury and disease progression in KPLA. Our findings reveal that KPLA patients with intrahepatic thrombophlebitis are more prone to developing sepsis and extrahepatic migratory infections. K. pneumoniae induces NET formation via the TLR4-PI3Kα-AKT signaling pathway, and C3 deposition on NETs significantly contributes to endothelial injury. In a KPLA mouse model, increased C3 levels were observed in the liver, with NETs carrying substantial amounts of C3, disrupting the endothelial barrier and exacerbating liver injury. Treatment with the C3 inhibitor AMY-101 reduced C3 deposition on NETs, alleviated endothelial damage, significantly improved survival, and reduced extrahepatic dissemination, inflammatory infiltration, and lung injury while also suppressing systemic inflammation. Our findings underscore the pivotal role of C3 in NET-mediated endothelial damage and the pathogenesis of KPLA. Thus, targeting C3 deposition on NETs may be a promising therapeutic strategy to reduce endothelial injury, thrombosis, and extrahepatic infections in KPLA without compromising neutrophil antimicrobial function.
DOI: 10.23669/1ztelp/opxi61
title: cda1055_dat_ParlaCAP-IT_sentences.tsv.zip

description: :unav
DOI: 10.6084/m9.figshare.28639523.v6
title: Neutrophil Extracellular Trap-borne C3-Driven Endothelial Dysfunction in <i>Klebsiella pneumoniae</i> Liver Abscess

description: <i>Klebsiella pneumoniae</i> (<i>K</i><i>.</i><i> pneumoniae</i>)<i> </i>liver abscess (KPLA) is a severe bacterial infection that is frequently complicated by intrahepatic thrombophlebitis and extrahepatic metastatic infections leading to high mortality rates. This study investigates the role of neutrophil extracellular traps (NETs) in endothelial injury and disease progression in KPLA. Our findings reveal that KPLA patients with intrahepatic thrombophlebitis are more prone to developing sepsis and extrahepatic migratory infections. <i>K. pneumoniae</i> induces NET formation via the TLR4-PI3Kα-AKT signaling pathway, and C3 deposition on NETs significantly contributes to endothelial injury. In a KPLA mouse model, increased C3 levels were observed in the liver, with NETs carrying substantial amounts of C3, disrupting the endothelial barrier and exacerbating liver injury. Treatment with the C3 inhibitor AMY-101 reduced C3 deposition on NETs, alleviated endothelial damage, significantly improved survival, and reduced extrahepatic dissemination, inflammatory infiltration, and lung injury while also suppressing systemic inflammation. Our findings underscore the pivotal role of C3 in NET-mediated endothelial damage and the pathogenesis of KPLA. Thus, targeting C3 deposition on NETs may be a promising therapeutic strategy to reduce endothelial injury, thrombosis, and extrahepatic infections in KPLA without compromising neutrophil antimicrobial function.
DOI: 10.6084/m9.figshare.28639523.v7
title: Neutrophil Extracellular Trap-borne C3-Driven Endothelial Dysfunction in Klebsiella pneumoniae Liver Abscess

description: Klebsiella pneumoniae (K. pneumoniae) liver abscess (KPLA) is a severe bacterial infection that is frequently complicated by intrahepatic thrombophlebitis and extrahepatic metastatic infections leading to high mortality rates. This study investigates the role of neutrophil extracellular traps (NETs) in endothelial injury and disease progression in KPLA. Our findings reveal that KPLA patients with intrahepatic thrombophlebitis are more prone to developing sepsis and extrahepatic migratory infections. K. pneumoniae induces NET formation via the TLR4-PI3Kα-AKT signaling pathway, and C3 deposition on NETs significantly contributes to endothelial injury. In a KPLA mouse model, increased C3 levels were observed in the liver, with NETs carrying substantial amounts of C3, disrupting the endothelial barrier and exacerbating liver injury. Treatment with the C3 inhibitor AMY-101 reduced C3 deposition on NETs, alleviated endothelial damage, significantly improved survival, and reduced extrahepatic dissemination, inflammatory infiltration, and lung injury while also suppressing systemic inflammation. Our findings underscore the pivotal role of C3 in NET-mediated endothelial damage and the pathogenesis of KPLA. Thus, targeting C3 deposition on NETs may be a promising therapeutic strategy to reduce endothelial injury, thrombosis, and extrahepatic infections in KPLA without compromising neutrophil antimicrobial function.
DOI: 10.23669/1ztelp/9wzrwn
title: cda1055_dat_ParlaCAP-NO_sentences.tsv.zip

description: :unav
DOI: 10.23669/1ztelp/eftyuf
title: cda1055_dat_ParlaCAP-SI_sentences.tsv.zip

description: :unav
DOI: 10.23669/1ztelp/ulv3qp
title: cda1055_dat_ParlaCAP-CZ_sentences.tsv.zip

description: :unav
DOI: 10.23669/1ztelp/6ndkij
title: cda1055_dat_ParlaCAP-PL_sentences.tsv.zip

description: :unav
DOI: 10.23669/1ztelp/8swyr6
title: README.md

description: :unav