cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.26496621
title: miRNA-143 as a potential biomarker in the detection of bladder cancer: a meta-analysis

description: <b>Aim:</b> This study aimed to systematically evaluate the value of miRNA-143 in the early detection of bladder cancer (BCa). <b>Methods:</b> CNKI, WanFang, PubMed and Wiley Online Library databases were explored according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses protocol. A random-effects model was used to obtain pooled sensitivity, specificity and other related indicates. <b>Results:</b> Six studies were included for analysis. The overall pooled sensitivity and specificity were 0.80 (95% CI: 0.74–0.85) and 0.85 (95% CI: 0.78–0.91), and the area under the curve was 0.88 (95% CI: 0.85–0.91). Coupled with miR-100, it showed better diagnostic power (area under the curve: 0.95). <b>Conclusion:</b> miRNA-143 may serve as a promising noninvasive tool for the early detection of BCa. Bladder cancer (BCa) is a common and deadly malignant tumor worldwide; however, noninvasive diagnosis can significantly improve the prognosis of patients. Recently, miRNAs have emerged as potential diagnostic biomarkers for BCa. Among them, miRNA-143 has shown promising results in several studies. This meta-analysis aimed to evaluate the overall diagnostic accuracy of miRNA-143 for BCa through a systematic review and meta-analysis of six published articles. Excitingly, the results of this meta-analysis suggest that miRNA-143 has potential diagnostic value in BCa. Particularly, miRNA-143 combined with miRNA-100 maintained better competence. Besides, miRNA-143 in plasma exhibited better diagnostic strength than that in urine. The authors believe that their study provides valuable insights into the use of miRNA-143 as a diagnostic biomarker for BCa. This study confirmed the promising diagnostic performance of miRNA-143 using meta-analysis. miRNA-143 had more potential for diagnosing bladder cancer (BCa) within Asian populations. The heterogeneity based on ethnicities might be the result of the single nucleotide polymorphisms of the <i>PAI-1</i> gene. miRNA-143 in plasma performed better compared with that in urine. Specific proteins in plasma might help isolate the miRNA-143 and improve its diagnostic performance. miRNA-143 coupled with miRNA-100 showed the best diagnostic performance among various combinations. More studies only focus between healthy population and non-muscle-invasive BCa or muscle-invasive BCa patients and healthy are demanding. Ununified screening protocols for miRNA-143 hinder the verification of its actual diagnostic value.
DOI: 10.6084/m9.figshare.26496621.v1
title: miRNA-143 as a potential biomarker in the detection of bladder cancer: a meta-analysis

description: <b>Aim:</b> This study aimed to systematically evaluate the value of miRNA-143 in the early detection of bladder cancer (BCa). <b>Methods:</b> CNKI, WanFang, PubMed and Wiley Online Library databases were explored according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses protocol. A random-effects model was used to obtain pooled sensitivity, specificity and other related indicates. <b>Results:</b> Six studies were included for analysis. The overall pooled sensitivity and specificity were 0.80 (95% CI: 0.74–0.85) and 0.85 (95% CI: 0.78–0.91), and the area under the curve was 0.88 (95% CI: 0.85–0.91). Coupled with miR-100, it showed better diagnostic power (area under the curve: 0.95). <b>Conclusion:</b> miRNA-143 may serve as a promising noninvasive tool for the early detection of BCa. Bladder cancer (BCa) is a common and deadly malignant tumor worldwide; however, noninvasive diagnosis can significantly improve the prognosis of patients. Recently, miRNAs have emerged as potential diagnostic biomarkers for BCa. Among them, miRNA-143 has shown promising results in several studies. This meta-analysis aimed to evaluate the overall diagnostic accuracy of miRNA-143 for BCa through a systematic review and meta-analysis of six published articles. Excitingly, the results of this meta-analysis suggest that miRNA-143 has potential diagnostic value in BCa. Particularly, miRNA-143 combined with miRNA-100 maintained better competence. Besides, miRNA-143 in plasma exhibited better diagnostic strength than that in urine. The authors believe that their study provides valuable insights into the use of miRNA-143 as a diagnostic biomarker for BCa. This study confirmed the promising diagnostic performance of miRNA-143 using meta-analysis. miRNA-143 had more potential for diagnosing bladder cancer (BCa) within Asian populations. The heterogeneity based on ethnicities might be the result of the single nucleotide polymorphisms of the <i>PAI-1</i> gene. miRNA-143 in plasma performed better compared with that in urine. Specific proteins in plasma might help isolate the miRNA-143 and improve its diagnostic performance. miRNA-143 coupled with miRNA-100 showed the best diagnostic performance among various combinations. More studies only focus between healthy population and non-muscle-invasive BCa or muscle-invasive BCa patients and healthy are demanding. Ununified screening protocols for miRNA-143 hinder the verification of its actual diagnostic value.
DOI: 10.6084/m9.figshare.26496624
title: The causality between Type 2 diabetes and breast cancer: a bidirectional two-sample Mendelian randomization study

description: <b>Objective:</b> Observational studies showed that Type 2 diabetes increased the risk of breast cancer, and <i>vice versa</i>. However, it is uncertain whether the link is causal or just due to confounding factors. Using bidirectional Mendelian randomization analysis, we assessed the bidirectional causal relationship from a genetic level. <b>Methods:</b> Large genome-wide association studies yielded summary-level data for Type 2 diabetes and breast cancer. <b>Results:</b> Genetically predicted Type 2 diabetes presented no statistically significant association with overall breast cancer or its subtypes. Similarly, genetically predicted overall breast cancer or its subtypes had no causal effect on Type 2 diabetes. Sensitivity analyses yielded similar results. <b>Conclusion:</b> Our bidirectional Mendelian randomization studies revealed no causal links between Type 2 diabetes and breast cancer. Type 2 diabetes had no causal effect on the development of overall breast cancer, estrogen receptor (ER)+ or ER- subtypes. Overall breast cancer, ER+ and ER- subtypes had no causal effect on the development of Type 2 diabetes. The previously observed substantial relationships between Type 2 diabetes and breast cancer in observational studies could be explained by failing to account for confounders completely.
DOI: 10.6084/m9.figshare.26496624.v1
title: The causality between Type 2 diabetes and breast cancer: a bidirectional two-sample Mendelian randomization study

description: <b>Objective:</b> Observational studies showed that Type 2 diabetes increased the risk of breast cancer, and <i>vice versa</i>. However, it is uncertain whether the link is causal or just due to confounding factors. Using bidirectional Mendelian randomization analysis, we assessed the bidirectional causal relationship from a genetic level. <b>Methods:</b> Large genome-wide association studies yielded summary-level data for Type 2 diabetes and breast cancer. <b>Results:</b> Genetically predicted Type 2 diabetes presented no statistically significant association with overall breast cancer or its subtypes. Similarly, genetically predicted overall breast cancer or its subtypes had no causal effect on Type 2 diabetes. Sensitivity analyses yielded similar results. <b>Conclusion:</b> Our bidirectional Mendelian randomization studies revealed no causal links between Type 2 diabetes and breast cancer. Type 2 diabetes had no causal effect on the development of overall breast cancer, estrogen receptor (ER)+ or ER- subtypes. Overall breast cancer, ER+ and ER- subtypes had no causal effect on the development of Type 2 diabetes. The previously observed substantial relationships between Type 2 diabetes and breast cancer in observational studies could be explained by failing to account for confounders completely.
DOI: 10.35003/i9vwg5/fr0sfn
title: 1-s2.0-S001670372100301X-mmc1.tab

description: :unav
DOI: 10.35003/i9vwg5/qjrkey
title: 1-s2.0-S001670372100301X-gr4_lrg.jpg

description: :unav
DOI: 10.35003/i9vwg5/xmeo3o
title: 1-s2.0-S001670372100301X-gr3_lrg.jpg

description: :unav
DOI: 10.35003/i9vwg5/s62n6t
title: 1-s2.0-S001670372100301X-gr7_lrg.jpg

description: :unav
DOI: 10.35003/i9vwg5/0ayhzf
title: 1-s2.0-S001670372100301X-gr5_lrg.jpg

description: :unav
DOI: 10.35003/i9vwg5/aezcvc
title: 1-s2.0-S001670372100301X-gr2_lrg.jpg

description: :unav
DOI: 10.35003/i9vwg5/psarki
title: 1-s2.0-S001670372100301X-gr10_lrg.jpg

description: :unav
DOI: 10.35003/i9vwg5/qbjdra
title: 1-s2.0-S001670372100301X-gr1_lrg.jpg

description: :unav
DOI: 10.35003/i9vwg5/n5hecc
title: 1-s2.0-S001670372100301X-gr6_lrg.jpg

description: :unav
DOI: 10.35003/i9vwg5/cnuz0d
title: Table_1.xlsx

description: :unav
DOI: 10.35003/i9vwg5/f0aupb
title: 1-s2.0-S001670372100301X-gr11_lrg.jpg

description: :unav
DOI: 10.35003/i9vwg5/karimj
title: 1-s2.0-S001670372100301X-gr8_lrg.jpg

description: :unav
DOI: 10.35003/i9vwg5/oqp2ri
title: Appendix A Supplementary material.tab

description: :unav
DOI: 10.35003/i9vwg5/tva7qo
title: 1-s2.0-S001670372100301X-gr9_lrg.jpg

description: :unav
DOI: 10.35003/i9vwg5
title: Replication Data for: Graphite in ureilites, enstatite chondrites, and unique clasts in ordinary chondrites – Insights from the carbon-isotope composition

description: Abstract: Carbon is of fundamental interest for constraining the volatile element inventory of terrestrial planets. In some meteorites, like ureilites and enstatite chondrites, graphite is the major carbon-carrier. Here, we report the in-situ analyses of graphite in 19 ureilites, 11 enstatite chondrites, and 3 graphite-bearing clasts in ordinary chondrites by secondary ion mass spectrometry (SIMS). In coarse-grained ureilites the obtained carbon-compositions of graphite range from –9.2‰ to –0.1‰ (δ13C). The carbon-composition tends to be homogeneous within a sample and correlates with the Fa content in olivine. In contrast, fine-grained ureilites exhibit considerable intra-sample heterogeneity, and graphite tends towards 13C-enriched compositions (up to +10.4‰). Isotopic and petrographic differences are presumably a result of post-igneous shock processing, including annealing during impact smelting. Enstatite chondrites host a variety of graphite morphologies, occurring in two distinct assemblages: Silicate-associated graphite (SAG) and metal-associated graphite (MAG). These assemblages show diverging carbon-compositions: SAG consistently exhibits δ13C in a narrow range between –4‰ and +1‰, very similar to the bulk silicate Earth value. In contrast, diverse compositions from –19.7‰ to +13.7‰ were observed for MAG. These differences are likely pre-accretionary in origin and potentially point towards isotopically distinct precursors. If Earth accreted from enstatite-chondrite-like material, carbon potentially hosted by Earth's core may have an isotopically light signature when compared to the mantle. Although graphite-bearing clasts in unequilibrated ordinary chondrites (UOCs) are extraordinarily rare, these clasts are of particular interest as they might represent materials, not corresponding to known meteorites. Graphite from these clasts show coinciding carbon-compositions with a mean δ13C close to –1‰. Although the coinciding compositions might argue for a genetic relationship among the clasts, petrographic evidence suggests they have experienced distinct thermal histories.
DOI: 10.35003/i9vwg5/hgze9t
title: Figure captions.docx

description: :unav
DOI: 10.15468/dl.chqfha
title: Occurrence Download

description: A dataset containing 220925 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Opuntia Mill.)",
 "HasCoordinate is true",
 "OccurrenceStatus is Present",
 "HasGeospatialIssue is false",
 {
 "not" : {
 "BasisOfRecord" : [
 "is one of (Fossil, Living Specimen)"
 ]
 }
 },
 {
 "or" : [
 {
 "not" : {
 "EstablishmentMeans" : [
 "is one of (MANAGED, INTRODUCED)"
 ]
 }
 },
 "EstablishmentMeans is null"
 ]
 }
 ]
}

 The dataset includes 220925 records from 763 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0049258-240626123714530/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.pukxrs
title: Occurrence Download

description: A dataset containing 141 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Montana montana (Kollar, 1833)",
 "HasCoordinate is true"
 ]
}

 The dataset includes 141 records from 12 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0049306-240626123714530/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.m9w4et
title: Occurrence Download

description: A dataset containing 1 species occurrences available in GBIF matching the query:
{
 "Geometry" : [
 "MULTIPOLYGON (((146.46731 -36.288152, 146.471802 -36.288152, 146.471802 -36.285906, 146.46731 -36.285906, 146.46731 -36.288152)), ((146.46731 -36.288152, 146.465064 -36.288152, 146.465064 -36.290398, 146.46731 -36.290398, 146.46731 -36.288152)))"
 ]
}

 The dataset includes 1 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0049307-240626123714530/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.6084/m9.figshare.26496304
title: ISX 240619 Run Files

description: Peripheral human neutrophils were isolated as above and pretreated with 50 μg/mL of purified human THP, sialic acid (500 ng/mL, catalog no. A0812, Sigma Aldrich), or mock-treated, and incubated at 37°C in 5% CO2 for 30 min, and then incubated for an additional 2.5 h with PMA (25 nM). The following antibodies (0.5 μg/mL) and dyes (concentrations provided below) were added: Anti-MPO-FITC (clone M1/70, catalog no. 553310; BD Biosciences), Fc Block, Live/Dead Near IR (1:200 of stock, catalog no. L34975; Thermo Fisher Scientific), Sytox orange (100 nM, catalog no. S34861; Thermo Fisher Scientific), and Hoechst 33342 (200 nM, catalog no. 62249; Thermo Fisher Scientific). After a 30-minute incubation on ice, samples were washed 1X, resuspended in a 1:1 mixture of fresh FACS buffer and PBS. Cell morphology via imaging flow cytometry was assessed as described previously (PMID: 30985081). An Amnis ImageStream X Mark II imaging flow cytometer was used for data acquisition with a 60X objective, low flow rate and high sensitivity, and 405, 488, 561 and 635 nm lasers set to 120, 150, 100 and 150 mW respectively. Data were analyzed using the IDEAS version 6.3 software package. Clipped images were retained due to the large size of NETs, and single stained controls were used for compensation. Masking was performed using the default “object (tight)” and “morphology” algorithms as described (PMID: 30985081). Statistics reports were generated using IDEAS and processed IDEAS data analysis files (.daf) were then analyzed in FCS Express 7 to generate analysis plots.
DOI: 10.6084/m9.figshare.26496304.v1
title: ISX 240619 Run Files

description: Peripheral human neutrophils were isolated as above and pretreated with 50 μg/mL of purified human THP, sialic acid (500 ng/mL, catalog no. A0812, Sigma Aldrich), or mock-treated, and incubated at 37°C in 5% CO2 for 30 min, and then incubated for an additional 2.5 h with PMA (25 nM). The following antibodies (0.5 μg/mL) and dyes (concentrations provided below) were added: Anti-MPO-FITC (clone M1/70, catalog no. 553310; BD Biosciences), Fc Block, Live/Dead Near IR (1:200 of stock, catalog no. L34975; Thermo Fisher Scientific), Sytox orange (100 nM, catalog no. S34861; Thermo Fisher Scientific), and Hoechst 33342 (200 nM, catalog no. 62249; Thermo Fisher Scientific). After a 30-minute incubation on ice, samples were washed 1X, resuspended in a 1:1 mixture of fresh FACS buffer and PBS. Cell morphology via imaging flow cytometry was assessed as described previously (PMID: 30985081). An Amnis ImageStream X Mark II imaging flow cytometer was used for data acquisition with a 60X objective, low flow rate and high sensitivity, and 405, 488, 561 and 635 nm lasers set to 120, 150, 100 and 150 mW respectively. Data were analyzed using the IDEAS version 6.3 software package. Clipped images were retained due to the large size of NETs, and single stained controls were used for compensation. Masking was performed using the default “object (tight)” and “morphology” algorithms as described (PMID: 30985081). Statistics reports were generated using IDEAS and processed IDEAS data analysis files (.daf) were then analyzed in FCS Express 7 to generate analysis plots.
DOI: 10.15468/dl.796ybb
title: Occurrence Download

description: A dataset containing 70 species occurrences available in GBIF matching the query:
{
 "Geometry" : [
 "MULTIPOLYGON (((149.319475 -32.883521, 149.321721 -32.883521, 149.321721 -32.879029, 149.319475 -32.879029, 149.319475 -32.883521)), ((149.319475 -32.883521, 149.312737 -32.883521, 149.312737 -32.896996, 149.319475 -32.896996, 149.319475 -32.899241, 149.326212 -32.899241, 149.326212 -32.89475, 149.335195 -32.89475, 149.335195 -32.896996, 149.341933 -32.896996, 149.341933 -32.899241, 149.350916 -32.899241, 149.350916 -32.905979, 149.355408 -32.905979, 149.355408 -32.903733, 149.364391 -32.903733, 149.364391 -32.883521, 149.362145 -32.883521, 149.362145 -32.888012, 149.357653 -32.888012, 149.357653 -32.879029, 149.362145 -32.879029, 149.362145 -32.876783, 149.355408 -32.876783, 149.355408 -32.874538, 149.353162 -32.874538, 149.353162 -32.872292, 149.34867 -32.872292, 149.34867 -32.870046, 149.346424 -32.870046, 149.346424 -32.885767, 149.323966 -32.885767, 149.323966 -32.888012, 149.319475 -32.888012, 149.319475 -32.883521)))"
 ]
}

 The dataset includes 70 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0049308-240626123714530/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.jb9yn6
title: Occurrence Download

description: A dataset containing 486 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Myrmecophilus acervorum (Panzer, 1799)",
 "HasCoordinate is true"
 ]
}

 The dataset includes 486 records from 29 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0049310-240626123714530/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.ew5b99
title: Occurrence Download

description: A dataset containing 2323564 species occurrences available in GBIF matching the query:
{
 "and" : [
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "TaxonKey is Pica hudsonia (Sabine, 1823)"
 ]
}

 The dataset includes 2323564 records from 78 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0049266-240626123714530/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.k7854s
title: Occurrence Download

description: A dataset containing 3362403 species occurrences available in GBIF matching the query:
{
 "and" : [
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "TaxonKey is Passer montanus (Linnaeus, 1758)"
 ]
}

 The dataset includes 3362403 records from 1499 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0049265-240626123714530/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.cny4au
title: Occurrence Download

description: A dataset listing the 1370 species recorded in GBIF matching the query:
{
 "and" : [
 "Country is Zimbabwe",
 "Geometry POLYGON((26.91167 -19.38781,27.23192 -19.37866,27.57963 -19.07671,26.81102 -18.51855,26.45416 -18.51855,25.74045 -18.1617,25.41105 -18.15254,25.79535 -18.8205,26.10646 -19.49761,26.71037 -19.90937,26.91167 -19.38781))",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present"
 ]
}

 The dataset's 1370 records were derived from 82 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0142684-230224095556074/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.sg284y
title: Occurrence Download

description: A dataset containing 73 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Trillium kurabayashii J.D.Freeman"
 ]
}

 The dataset includes 73 records from 12 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0004320-171025204727650/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.o6rfqu
title: Occurrence Download

description: A dataset containing 160 species occurrences available in GBIF matching the query:
{
 "and" : [
 "BasisOfRecord is Human Observation",
 "Country is Germany",
 "HasCoordinate is true",
 "TaxonKey is Rangifer tarandus (Linnaeus, 1758)",
 "HasGeospatialIssue is false"
 ]
}

 The dataset includes 160 records from 49 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0004320-171124123535762/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.yh4va7
title: Occurrence Download

description: A dataset containing 107 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Geometry POLYGON((119.20546 -6.74874,120.69098 -6.74874,120.69098 -4.74925,119.20546 -4.74925,119.20546 -6.74874))",
 "OccurrenceStatus is Present",
 "TaxonKey is Zingiberales"
 ]
}

 The dataset includes 107 records from 8 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0142681-230224095556074/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.2vtcuh
title: Occurrence Download

description: A dataset containing 13 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Collabium delavayi (Gagnep.) Seidenf."
 ]
}

 The dataset includes 13 records from 6 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0142683-230224095556074/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.7jegeh
title: Occurrence Download

description: A dataset containing 15286 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Vulpes lagopus (Linnaeus, 1758)"
 ]
}

 The dataset includes 15286 records from 169 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0142687-230224095556074/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.mixe1e
title: Occurrence Download

description: A dataset containing 175 species occurrences available in GBIF matching the query:
{
 "and" : [
 "DatasetKey is Actualización de las bases de datos del Herbario XAL. Fase III",
 "TaxonKey is Ocotea helicterifolia (Meisn.) Hemsl."
 ]
}

 The dataset includes 175 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0004320-171219132708484/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.