cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.5281/zenodo.4147830
title: Maternal anxiety during pregnancy and newborn epigenome-wide DNA methylation

description: Maternal anxiety during pregnancy is associated with adverse fetal, neonatal, and child outcomes, but biological mechanisms remain unclear. Altered fetal DNA methylation (DNAm) has been proposed as a potential underlying mechanism. In the current study, we performed a meta-analysis to examine the associations between maternal anxiety, measured prospectively during pregnancy, and genome-wide DNAm from umbilical cord blood. Sixteen non-overlapping cohorts from 12 independent longitudinal studies of the Pregnancy And Childhood Epigenetics Consortium participated, resulting in a combined dataset of 7 243 mother-child dyads. We examined prenatal anxiety in relation to genome-wide DNAm and differentially methylated regions. We observed no association between the general symptoms of anxiety during pregnancy or pregnancy-related anxiety, and DNAm at any of the CpG sites, after multiple-testing correction. Further, we identify no differentially methylated regions associated with maternal anxiety. At the cohort-level, of the 21 associations observed in individual cohorts, none replicated consistently in the other cohorts. In conclusion, contrary to some previous studies proposing cord blood DNAm as a promising potential mechanism explaining the link between maternal anxiety during pregnancy and adverse outcomes in offspring, we found no consistent evidence for any robust associations between maternal anxiety and DNAm in cord blood. Larger studies and analysis of DNAm in other tissues may be needed to establish subtle or subgroup-specific associations between maternal anxiety and the fetal epigenome. In this dataset, we present all probe-level summary statistics for one of the two secondary meta-analyses, as described in more detail in the publication (Sammallahti, Cortes Hidalgo, et al, Molecular Psychiatry, in press). We present here the associations between maternal anxiety during pregnancy (general rather than pregnancy-related anxiety; binary variable where 1=high and 0=low anxiety) and cord blood DNA methylation at birth (continuous beta values where 1=completely methylated and 0=completely unmethylated) of <strong>CpG sites that were only present in the Illumina EPIC array</strong> (not on the Illumina 450k array). We adjusted for child sex, maternal socioeconomic class, maternal age, ancestry, batch, and cell counts. The sample size, unadjusted p-value, the z estimate from the sample-size weighted meta-analysis, and the direction of effects across each cohorts are shown. Upload of this dataset was completed by The EWAS Catalog team. The data can be queried along with hundreds of other EWAS at ewascatalog.org. To upload your EWAS summary statistics and have a zenodo DOI generated for you go to ewascatalog.org/upload
DOI: 10.5281/zenodo.4147845
title: Maternal anxiety during pregnancy and newborn epigenome-wide DNA methylation

description: Maternal anxiety during pregnancy is associated with adverse fetal, neonatal, and child outcomes, but biological mechanisms remain unclear. Altered fetal DNA methylation (DNAm) has been proposed as a potential underlying mechanism. In the current study, we performed a meta-analysis to examine the associations between maternal anxiety, measured prospectively during pregnancy, and genome-wide DNAm from umbilical cord blood. Sixteen non-overlapping cohorts from 12 independent longitudinal studies of the Pregnancy And Childhood Epigenetics Consortium participated, resulting in a combined dataset of 7 243 mother-child dyads. We examined prenatal anxiety in relation to genome-wide DNAm and differentially methylated regions. We observed no association between the general symptoms of anxiety during pregnancy or pregnancy-related anxiety, and DNAm at any of the CpG sites, after multiple-testing correction. Further, we identify no differentially methylated regions associated with maternal anxiety. At the cohort-level, of the 21 associations observed in individual cohorts, none replicated consistently in the other cohorts. In conclusion, contrary to some previous studies proposing cord blood DNAm as a promising potential mechanism explaining the link between maternal anxiety during pregnancy and adverse outcomes in offspring, we found no consistent evidence for any robust associations between maternal anxiety and DNAm in cord blood. Larger studies and analysis of DNAm in other tissues may be needed to establish subtle or subgroup-specific associations between maternal anxiety and the fetal epigenome. In this dataset, we present all probe-level summary statistics for one of the two secondary meta-analyses, as described in more detail in the publication (Sammallahti, Cortes Hidalgo, et al, Molecular Psychiatry, in press). We present the associations between maternal <strong>pregnancy-related anxiety</strong> during pregnancy (binary variable where 1=high and 0=low anxiety) and cord blood DNA methylation at birth (continuous beta values where 1=completely methylated and 0=completely unmethylated). We adjusted for child sex, maternal socioeconomic class, maternal age, ancestry, batch, and cell counts. The sample size, unadjusted p-value, the z estimate from the sample-size weighted meta-analysis, and the direction of effects across each cohorts are included. Upload of this dataset was completed by The EWAS Catalog team. The data can be queried along with hundreds of other EWAS at ewascatalog.org. To upload your EWAS summary statistics and have a zenodo DOI generated for you go to ewascatalog.org/upload
DOI: 10.5281/zenodo.4147844
title: Maternal anxiety during pregnancy and newborn epigenome-wide DNA methylation

description: Maternal anxiety during pregnancy is associated with adverse fetal, neonatal, and child outcomes, but biological mechanisms remain unclear. Altered fetal DNA methylation (DNAm) has been proposed as a potential underlying mechanism. In the current study, we performed a meta-analysis to examine the associations between maternal anxiety, measured prospectively during pregnancy, and genome-wide DNAm from umbilical cord blood. Sixteen non-overlapping cohorts from 12 independent longitudinal studies of the Pregnancy And Childhood Epigenetics Consortium participated, resulting in a combined dataset of 7 243 mother-child dyads. We examined prenatal anxiety in relation to genome-wide DNAm and differentially methylated regions. We observed no association between the general symptoms of anxiety during pregnancy or pregnancy-related anxiety, and DNAm at any of the CpG sites, after multiple-testing correction. Further, we identify no differentially methylated regions associated with maternal anxiety. At the cohort-level, of the 21 associations observed in individual cohorts, none replicated consistently in the other cohorts. In conclusion, contrary to some previous studies proposing cord blood DNAm as a promising potential mechanism explaining the link between maternal anxiety during pregnancy and adverse outcomes in offspring, we found no consistent evidence for any robust associations between maternal anxiety and DNAm in cord blood. Larger studies and analysis of DNAm in other tissues may be needed to establish subtle or subgroup-specific associations between maternal anxiety and the fetal epigenome. In this dataset, we present all probe-level summary statistics for one of the two secondary meta-analyses, as described in more detail in the publication (Sammallahti, Cortes Hidalgo, et al, Molecular Psychiatry, in press). We present the associations between maternal <strong>pregnancy-related anxiety</strong> during pregnancy (binary variable where 1=high and 0=low anxiety) and cord blood DNA methylation at birth (continuous beta values where 1=completely methylated and 0=completely unmethylated). We adjusted for child sex, maternal socioeconomic class, maternal age, ancestry, batch, and cell counts. The sample size, unadjusted p-value, the z estimate from the sample-size weighted meta-analysis, and the direction of effects across each cohorts are included. Upload of this dataset was completed by The EWAS Catalog team. The data can be queried along with hundreds of other EWAS at ewascatalog.org. To upload your EWAS summary statistics and have a zenodo DOI generated for you go to ewascatalog.org/upload
DOI: 10.5281/zenodo.4031387
title: Epigenetic Profiling of Social Communication Trajectories and Co-occurring Mental Health Problems: A Prospective, Methylome-wide Association Study

description: While previous studies suggest that both genetic and environmental factors play an important role in the development of autism-related traits, little is known about potential biological mechanisms underlying these associations. Using data from the Avon Longitudinal Study of Parents and Children (ALSPAC), we examined prospective associations between DNA methylation (DNAm: N-birth=804, N-age7=877) and trajectories of social communication deficits (8-17 years). Methylomic variation at three loci across the genome (false discovery rate=0.048) differentiated children following high (n=80) versus low (n=724) trajectories of social communication deficits. This differential DNAm was specific to the neonatal period and not observed at age 7. Associations between DNAm and trajectory membership remained robust after controlling for co-occurring mental health problems (i.e., hyperactivity/inattention, conduct problems). The three loci identified at birth were not replicated in the Generation R Study. However, to the best of our knowledge, ALSPAC is the only study to date that is prospective enough to examine DNAm in relation to longitudinal trajectories of social communication deficits from late childhood to late adolescence. Although the present findings might point to potentially novel sites that differentiate between a high versus low trajectory of social communication deficits, the results should be considered tentative until further replicated. This dataset contains summary statistics for the methylome-wide association study using DNAm data collected from individuals at age 7. Upload of this dataset was completed by The EWAS Catalog team. The data can be queried along with hundreds of other EWAS at ewascatalog.org. To upload your EWAS summary statistics and have a zenodo DOI generated for you go to ewascatalog.org/upload
DOI: 10.5281/zenodo.4031357
title: Epigenetic Profiling of Social Communication Trajectories and Co-occurring Mental Health Problems: A Prospective, Methylome-wide Association Study

description: While previous studies suggest that both genetic and environmental factors play an important role in the development of autism-related traits, little is known about potential biological mechanisms underlying these associations. Using data from the Avon Longitudinal Study of Parents and Children (ALSPAC), we examined prospective associations between DNA methylation (DNAm: N-birth=804, N-age7=877) and trajectories of social communication deficits (8-17 years). Methylomic variation at three loci across the genome (false discovery rate=0.048) differentiated children following high (n=80) versus low (n=724) trajectories of social communication deficits. This differential DNAm was specific to the neonatal period and not observed at age 7. Associations between DNAm and trajectory membership remained robust after controlling for co-occurring mental health problems (i.e., hyperactivity/inattention, conduct problems). The three loci identified at birth were not replicated in the Generation R Study. However, to the best of our knowledge, ALSPAC is the only study to date that is prospective enough to examine DNAm in relation to longitudinal trajectories of social communication deficits from late childhood to late adolescence. Although the present findings might point to potentially novel sites that differentiate between a high versus low trajectory of social communication deficits, the results should be considered tentative until further replicated. This dataset contains summary statistics for the methylome-wide association study using DNAm data collected from individuals at birth. Upload of this dataset was completed by The EWAS Catalog team. The data can be queried along with hundreds of other EWAS at ewascatalog.org. To upload your EWAS summary statistics and have a zenodo DOI generated for you go to ewascatalog.org/upload
DOI: 10.5281/zenodo.4031356
title: Epigenetic Profiling of Social Communication Trajectories and Co-occurring Mental Health Problems: A Prospective, Methylome-wide Association Study

description: While previous studies suggest that both genetic and environmental factors play an important role in the development of autism-related traits, little is known about potential biological mechanisms underlying these associations. Using data from the Avon Longitudinal Study of Parents and Children (ALSPAC), we examined prospective associations between DNA methylation (DNAm: N-birth=804, N-age7=877) and trajectories of social communication deficits (8-17 years). Methylomic variation at three loci across the genome (false discovery rate=0.048) differentiated children following high (n=80) versus low (n=724) trajectories of social communication deficits. This differential DNAm was specific to the neonatal period and not observed at age 7. Associations between DNAm and trajectory membership remained robust after controlling for co-occurring mental health problems (i.e., hyperactivity/inattention, conduct problems). The three loci identified at birth were not replicated in the Generation R Study. However, to the best of our knowledge, ALSPAC is the only study to date that is prospective enough to examine DNAm in relation to longitudinal trajectories of social communication deficits from late childhood to late adolescence. Although the present findings might point to potentially novel sites that differentiate between a high versus low trajectory of social communication deficits, the results should be considered tentative until further replicated. This dataset contains summary statistics for the methylome-wide association study using DNAm data collected from individuals at birth. Upload of this dataset was completed by The EWAS Catalog team. The data can be queried along with hundreds of other EWAS at ewascatalog.org. To upload your EWAS summary statistics and have a zenodo DOI generated for you go to ewascatalog.org/upload
DOI: 10.5281/zenodo.4031386
title: Epigenetic Profiling of Social Communication Trajectories and Co-occurring Mental Health Problems: A Prospective, Methylome-wide Association Study

description: While previous studies suggest that both genetic and environmental factors play an important role in the development of autism-related traits, little is known about potential biological mechanisms underlying these associations. Using data from the Avon Longitudinal Study of Parents and Children (ALSPAC), we examined prospective associations between DNA methylation (DNAm: N-birth=804, N-age7=877) and trajectories of social communication deficits (8-17 years). Methylomic variation at three loci across the genome (false discovery rate=0.048) differentiated children following high (n=80) versus low (n=724) trajectories of social communication deficits. This differential DNAm was specific to the neonatal period and not observed at age 7. Associations between DNAm and trajectory membership remained robust after controlling for co-occurring mental health problems (i.e., hyperactivity/inattention, conduct problems). The three loci identified at birth were not replicated in the Generation R Study. However, to the best of our knowledge, ALSPAC is the only study to date that is prospective enough to examine DNAm in relation to longitudinal trajectories of social communication deficits from late childhood to late adolescence. Although the present findings might point to potentially novel sites that differentiate between a high versus low trajectory of social communication deficits, the results should be considered tentative until further replicated. This dataset contains summary statistics for the methylome-wide association study using DNAm data collected from individuals at age 7. Upload of this dataset was completed by The EWAS Catalog team. The data can be queried along with hundreds of other EWAS at ewascatalog.org. To upload your EWAS summary statistics and have a zenodo DOI generated for you go to ewascatalog.org/upload
DOI: 10.15129/63b7b4a6-aa9c-4d62-826c-adf62c0eda9e
title: Wave propagation over obstacles

description: The data contained here is part of a set of experiments carried to understand how regular obstacles will affect the propagation of waves. Experiments carried consisted of a set of regular obstacles of measures 0.1m height, 1.6m width and 0.1m length. The obstacles were placed in the bottom of a wave flume tank, wave trains were produced and measured as they moved along the length of the tank. The waves were measured after the wave-maker, before the obstacle, over the obstacle and after the obstacle. The measurements were done using a set of wave probes that recorded the water surface displacement vs time. More information can be found in the readme file. Experiments were carried in two testing campaigns during 2019 and 2020.
DOI: 10.25573/data.10059455.v12
title: Monthly Summary_BCI, horizontal

description: Monthly and daily summary from Barro Colorado Island (BCI). Data organized in horizontal format for seasonal and inter-year comparisons<br>Location 9°9'42.36"N, 79°50'15.67"W<br>Parameters: air temperature, relative humidity, wind speed and direction, precipitation, sea surface temperature, solar radiation (pyranometer), air pressure, soil moisture, runoff, potential evapotranspiration, wet/dry season starting dates<br><br>Lutz catchment is a 9.73ha protected watershed on BCIThe Lutz tower was built in 1972 and was originally 42m. In 2002 it was increased to 48m<br>The data from 48m should be considered a separate data series from the data at 42m. Wind speed is significantly higher at 48m due to the distance to the top of the canopy.<br>The Clearing is a small, open area surrounded by forest and some buildings. Station established in 1972. Consists of a Stevenson screen with max/min thermometers and air pressure sensor. Temperature/humidity sensor, rain gauge and evaporation sensors are located at various locations around the screen.
DOI: 10.25573/data.10042400.v10
title: Barro Colorado Island, Lutz tower 1m_Relative Humidity

description: Barro Colorado Island (BCI), Lutz catchment tower, 1mLocation 9°9'42.36"N, 79°50'15.67"W<br>Relative Humidity, electronic sensor, interval max/min/avg<br>Lutz catchment is a 9.73ha protected watershed on BCIThe Lutz tower was built in 1972 and was originally 42m. In 2002 it was increased to 48m<br>
DOI: 10.25573/data.10042418.v10
title: Barro Colorado Island, Lutz tower 48m_Relative Humidity

description: Barro Colorado Island (BCI), Lutz catchment towerLocation 9°9'42.36"N, 79°50'15.67"W<br>Relative humidity, electronic sensor, interval max/min/avg<br>Lutz catchment is a 9.73ha protected watershed on BCIThe Lutz tower was built in 1972 and was originally 42m. In 2002 it was increased to 48m<br>
DOI: 10.25573/data.10042394.v10
title: Barro Colorado Island, Lutz tower 1m_Air Temperature

description: Barro Colorado Island (BCI), Lutz catchment towerLocation 9°9'42.36"N, 79°50'15.67"W<br>Air temperature, electronic sensor, interval max/min/avg<br>Lutz catchment is a 9.73ha protected watershed on BCIThe Lutz tower was built in 1972 and was originally 42m. In 2002 it was increased to 48m<br>
DOI: 10.5281/zenodo.4672262
title: Eurostat dataset weekly deaths from 2019

description: European Deaths by week, sex and NUTS 3 region published by eurostat.
DOI: 10.25573/data.10042409.v10
title: Barro Colorado Island, Lutz tower 20m_Air Temperature

description: Barro Colorado Island (BCI), Lutz catchment towerLocation 9°9'42.36"N, 79°50'15.67"W<br>Air temperature, electronic sensor, interval max/min/avg<br>Lutz catchment is a 9.73ha protected watershed on BCIThe Lutz tower was built in 1972 and was originally 42m. In 2002 it was increased to 48m<br>
DOI: 10.25573/data.10042442.v10
title: Barro Colorado Island, Lutz tower 48m_Air Temperature

description: Barro Colorado Island (BCI), Lutz catchment towerLocation 9°9'42.36"N, 79°50'15.67"W<br>Air temperature, electronic sensor, interval max/min/avg<br>Lutz catchment is a 9.73ha protected watershed on BCIThe Lutz tower was built in 1972 and was originally 42m. In 2002 it was increased to 48m<br>
DOI: 10.25573/data.10042397.v11
title: Barro Colorado Island, Lutz tower 42m_Relative Humidity

description: Barro Colorado Island (BCI), Lutz catchment towerLocation 9°9'42.36"N, 79°50'15.67"W<br>Relative humidity, electronic sensor, interval max/min/avg<br>Lutz catchment is a 9.73ha protected watershed on BCIThe Lutz tower was built in 1972 and was originally 42m. In 2002 it was increased to 48m<br>
DOI: 10.5281/zenodo.4147817
title: Maternal anxiety during pregnancy and newborn epigenome-wide DNA methylation

description: Maternal anxiety during pregnancy is associated with adverse fetal, neonatal, and child outcomes, but biological mechanisms remain unclear. Altered fetal DNA methylation (DNAm) has been proposed as a potential underlying mechanism. In the current study, we performed a meta-analysis to examine the associations between maternal anxiety, measured prospectively during pregnancy, and genome-wide DNAm from umbilical cord blood. Sixteen non-overlapping cohorts from 12 independent longitudinal studies of the Pregnancy And Childhood Epigenetics Consortium participated, resulting in a combined dataset of 7 243 mother-child dyads. We examined prenatal anxiety in relation to genome-wide DNAm and differentially methylated regions. We observed no association between the general symptoms of anxiety during pregnancy or pregnancy-related anxiety, and DNAm at any of the CpG sites, after multiple-testing correction. Further, we identify no differentially methylated regions associated with maternal anxiety. At the cohort-level, of the 21 associations observed in individual cohorts, none replicated consistently in the other cohorts. In conclusion, contrary to some previous studies proposing cord blood DNAm as a promising potential mechanism explaining the link between maternal anxiety during pregnancy and adverse outcomes in offspring, we found no consistent evidence for any robust associations between maternal anxiety and DNAm in cord blood. Larger studies and analysis of DNAm in other tissues may be needed to establish subtle or subgroup-specific associations between maternal anxiety and the fetal epigenome. In this dataset, we present all probe-level summary statistics for the primary meta-analysis, as described in more detail in the publication (Sammallahti, Cortes Hidalgo, et al, Molecular Psychiatry, in press). We present the associations between maternal anxiety during pregnancy (general rather than pregnancy-related anxiety; binary variable where 1=high and 0=low anxiety) and cord blood DNA methylation at birth (continuous beta values where 1=completely methylated and 0=completely unmethylated) . We adjusted for child sex, maternal socioeconomic class, maternal age, ancestry, batch, and cell counts. The sample size, unadjusted p-value, the z estimate from the sample-size weighted meta-analysis, and the direction of effects across each cohorts are included. Results from the secondary meta-analyses concerning pregnancy-related anxiety (https://doi.org/10.5281/zenodo.4147845) and CpG sites that are only available on the Illumina EPIC array (https://doi.org/10.5281/zenodo.4147831) are presented separately Upload of this dataset was completed by The EWAS Catalog team. The data can be queried along with hundreds of other EWAS at ewascatalog.org. To upload your EWAS summary statistics and have a zenodo DOI generated for you go to ewascatalog.org/upload