DOI: 10.57760/sciencedb.18419
title: Immunohistochemical expression and clinicopathological features of high-grade endometrial stromal sarcoma with ZC3H7B-BCOR gene fusion accompanied by MDM2 and CDK4 gene amplification
title: 同时伴有MDM2和CDK4基因扩增的ZC3H7B-BCOR基因融合的高级别子宫内膜间质肉瘤的免疫组化表达情况和临床病理特征

description: ① In the sparse area, the tumor cells were spindle-shaped, light-moderate atypia, and interstitial mucoid transformation② The tumor cells in the dense area were fat fusiform or oval, and the mucoid transformation was not obvious③ Necrosis is common④ Most of the CD10 was amplified by the 2+ expression Envision method by immunohistochemistry⑤ Immunohistochemical staining of BCOR showed 1+ expression in Envision method⑥ Immunohistochemical staining of CyclinD1 showed 2+ expression and magnification in Envision method⑦ Immunohistochemical staining of SATB2 diffuse 3+ expression was amplified by Envision method⑧ Immunohistochemical staining of MDM2 diffuse 3+ expression was amplified by Envision method⑨ Immunohistochemical staining of CDK4 diffuse 3+ expression was amplified by Envision methodNote: The staining intensity is judged by the tan depth of the positive area, 0 (negative), 1+ (light yellow), 2+ (light brown), 3+ (dark brown).Figure 1-3 FISH results of MDM2, CDK4 and BCOR genesTable 1 Summary of clinicopathologic features of high-grade endometrial stromal sarcoma with ZC3H7B-BCOR gene fusion reported in this case and in the literatureTable 1 deals with the list of referencesLiterature [5]Mansor, S., Kuick, C. H., Lim, S. L., et al. ZC3H7B-BCOR-Rearranged Endometrial Stromal Sarcomas: A Distinct Subset Merits its Own Classification?. International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists, 38(5), 420–425. https://doi.org/10.1097/PGP.0000000000000523Literature [7]Zhao, L., Cheng, Y. W., & Policarpio-Nicolas, et al. ZC3H7B-BCOR Fusion High-grade Endometrial Stromal Sarcoma With Morphologic Features of Low-grade Endometrial Stromal Sarcoma. A Case Report and Review of Literature. International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists, 42(6), 597–601. https://doi.org/10.1097/PGP.0000000000000917Literature [8]Ondič, O., Bednářová, B., Ptáková, N., et al. ZC3H7B-BCOR high-grade endometrial stromal sarcoma may present as myoma nascens with cytoplasmic signet ring cell change. Virchows Archiv : an international journal of pathology, 476(4), 615–619. https://doi.org/10.1007/s00428-020-02744-5Literature [9]Lu, B., Chen, J., Shao, Y., et al. Two cases of ZC3H7B-BCOR high grade endometrial stromal sarcoma with an extension on its morphological features. Pathology, 52(6), 708–712. https://doi.org/10.1016/j.pathol.2020.05.007Literature [10]Zhi, W., Zheng, X., & Jin, Y. ZC3H7B-BCOR High-Grade Endometrial Stromal Sarcoma with a Mucoid Grossly Feature: A Case Report and Literature Review. International journal of women's health, 14, 1701–1708. https://doi.org/10.2147/IJWH.S390042Literature [11]Nagaputra J , Goh R , Kuick C ,et al.ZC3H7B-BCOR high-grade endometrial stromal sarcoma with osseous metaplasia: Unique feature in a recently defined entity[J].Human Pathology: Case Reports, 2019.https://doi.org/10.1016/j.ehpc.2018.11.002Table 2 Immunohistochemical expression of 24 cases in the literature and this case; The horizontal coordinate is immunohistochemical antibody; The ordinate is the number of cases
description: ① In the sparse area, the tumor cells were spindle-shaped, light-moderate atypia, and interstitial mucoid transformation② The tumor cells in the dense area were fat fusiform or oval, and the mucoid transformation was not obvious③ Necrosis is common④ Most of the CD10 was amplified by the 2+ expression Envision method by immunohistochemistry⑤ Immunohistochemical staining of BCOR showed 1+ expression in Envision method⑥ Immunohistochemical staining of CyclinD1 showed 2+ expression and magnification in Envision method⑦ Immunohistochemical staining of SATB2 diffuse 3+ expression was amplified by Envision method⑧ Immunohistochemical staining of MDM2 diffuse 3+ expression was amplified by Envision method⑨ Immunohistochemical staining of CDK4 diffuse 3+ expression was amplified by Envision methodNote: The staining intensity is judged by the tan depth of the positive area, 0 (negative), 1+ (light yellow), 2+ (light brown), 3+ (dark brown).Figure 1-3 FISH results of MDM2, CDK4 and BCOR genesTable 1 Summary of clinicopathologic features of high-grade endometrial stromal sarcoma with ZC3H7B-BCOR gene fusion reported in this case and in the literatureTable 1 deals with the list of referencesLiterature [5]Mansor, S., Kuick, C. H., Lim, S. L., et al. ZC3H7B-BCOR-Rearranged Endometrial Stromal Sarcomas: A Distinct Subset Merits its Own Classification?. International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists, 38(5), 420–425. https://doi.org/10.1097/PGP.0000000000000523Literature [7]Zhao, L., Cheng, Y. W., & Policarpio-Nicolas, et al. ZC3H7B-BCOR Fusion High-grade Endometrial Stromal Sarcoma With Morphologic Features of Low-grade Endometrial Stromal Sarcoma. A Case Report and Review of Literature. International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists, 42(6), 597–601. https://doi.org/10.1097/PGP.0000000000000917Literature [8]Ondič, O., Bednářová, B., Ptáková, N., et al. ZC3H7B-BCOR high-grade endometrial stromal sarcoma may present as myoma nascens with cytoplasmic signet ring cell change. Virchows Archiv : an international journal of pathology, 476(4), 615–619. https://doi.org/10.1007/s00428-020-02744-5Literature [9]Lu, B., Chen, J., Shao, Y., et al. Two cases of ZC3H7B-BCOR high grade endometrial stromal sarcoma with an extension on its morphological features. Pathology, 52(6), 708–712. https://doi.org/10.1016/j.pathol.2020.05.007Literature [10]Zhi, W., Zheng, X., & Jin, Y. ZC3H7B-BCOR High-Grade Endometrial Stromal Sarcoma with a Mucoid Grossly Feature: A Case Report and Literature Review. International journal of women's health, 14, 1701–1708. https://doi.org/10.2147/IJWH.S390042Literature [11]Nagaputra J , Goh R , Kuick C ,et al.ZC3H7B-BCOR high-grade endometrial stromal sarcoma with osseous metaplasia: Unique feature in a recently defined entity[J].Human Pathology: Case Reports, 2019.https://doi.org/10.1016/j.ehpc.2018.11.002Table 2 Immunohistochemical expression of 24 cases in the literature and this case; The horizontal coordinate is immunohistochemical antibody; The ordinate is the number of cases