cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.16973044.v1
title: Supplementary Material for: Retrograde Pyelography in the Presence of Urothelial Bladder Cancer Does Not Affect the Risk of Upper Tract Urothelial Cancer: A Retrospective Analysis of a Single-Centre Cohort

description: <b><i>Objective:</i></b> Patients with bladder cancer (BC) are at risk of developing upper tract urothelial carcinoma (UTUC). Therefore, CT urography is recommended for follow-up. To avoid intravenous contrast agents, retrograde pyelography (RPG) is an alternative. However, it is still unclear whether RPG increases the incidence of UTUC. The aim of this study was to investigate the impact of RPG in the presence of BC on the risk of developing UTUC. <b><i>Patients and Methods:</i></b> Retrospectively analysing a total of 3,680 RPGs between 2009 and 2016, all patients with simultaneous BC (group 1) and those without synchronous BC (group 2) during RPG were compared. All patients were risk stratified according to the EORTC bladder calculator. In patients without BC during RPG, risk stratification was based on the worst prior tumour characteristics. <b><i>Results:</i></b> A total of 145 patients with a history of BC were analysed. Of these, 112 patients underwent RPG with simultaneous BC. UTUC developed in 6 of 112 patients (5.4%) and 58.9% (66/112) had high-risk BC according to the EORTC bladder calculator. In the control group, one out of 33 (3%) patients with metachronous high-risk BC developed UTUC. <b><i>Conclusions:</i></b> Using RPG in the presence of BC did not increase the risk of UTUC. Due to the predominant number of high-risk/high-grade tumours, individual tumour biology appears to be the primary driver for the development of UTUC.
DOI: 10.6084/m9.figshare.780820.v1
title: IJAMC Volume 3(4)

description: IJAMC International Journal of Applied Mathematics and Computation<br>ISSN 0974 - 4665 (print version)<br>ISSN 0974 - 4673 (electronic version)<br>4 Issue per Year This International Journal of Applied Mathematics and Computation (IJAMC) is of interest to a wide audience of mathematicians, scientists and engineers concerned with the practical issues in computational mathematics.
DOI: 10.6084/m9.figshare.19651314.v4
title: Figure 2: Epitope Maps and confusion matrix with BM5 Ab Crystal inputs

description: One of AbEMap's applications is to map epitope on a given antigen crystal structure if the antibody structure (bound or unbound) is known. The results in this dataset are pdb files of the 40 antigens in Zhiping Weng's docking benchmark v. 5.0 with their b-factor changed to our protocol's score to reflect the likelihood of each atom being in the epitope when in complex with the respective antibodies. The summary confusion matrix (residue based) for the epitope mapping done by AbEMap on the 40 antigens in BM5 with antibody crystal structures as input is also included. The text file contains the True Positive (TP), False Positive (FP), False Negative (FN) and True Negative (TN) counts for each antibody-antigen complex at different residue ranking thresholds (Top1, Top5, Top10, ... Top120).
DOI: 10.6084/m9.figshare.858898.v1
title: CB2 Dual event Tuberculosis dataset

description: dataset used in PMID:24144044 and elsewhere
DOI: 10.6084/m9.figshare.19122230.v1
title: Participant Information Sheet.docx

description: Participant information sheet for the study "<b>Effectiveness of a peanut ball device during labour on maternal and neonatal outcomes: Randomized controlled trial "</b><b></b>
DOI: 10.6084/m9.figshare.21340176.v1
title: Supplementary Material to Leuzinger et al. - Latest Maastrichtian middle- and high-latitude mosasaurs and fish isotopic composition: carbon source, thermoregulation strategy and thermal latitudinal gradient

description: Supplementary Figures: photographs of the fossil material. Supplementary Table 1: minor element and REE concentrations of our fossil material. Supplementary Table 2: stable isotopes data from the literature used in Fig. 4
DOI: 10.6084/m9.figshare.24434563.v1
title: Supplementary Material for: Aortic steal correlates with acute organ dysfunction and short-term outcomes in neonates with vein of Galen malformation

description: Introduction Vein of Galen aneurysmal malformation (VGAM) is a rare, congenital cerebrovascular malformation with high morbidity and mortality. Parameters to foresee clinical progression and allow individualized parent counseling are lacking. The aim of this study was to evaluate aortic steal measured by Doppler ultrasound as a prognostic parameter in these neonates. Methods Retrospective monocentric analysis of cardiac ultrasound exams before embolization in neonates with VGAM. Calculation of percentage of aortic steal by measurement of time-averaged maximum velocity above and below the zero flow-baseline by pulsed Doppler ultrasound at the preductal aortic isthmus. Evaluation of association of aortic steal with parameters of acute organ dysfunction (Bicêtre neonatal evaluation score (BNES), neonatal multiple organ dysfunction score (NeoMODS) and mortality and determination of correlation between aortic steal and cerebral damage on initial and follow-up cMRI. Results Twelve neonates were included, of which 3 died. Per 10 percentage point increase of aortic steal, BNES decreased by 1.64 (95 % confidence interval (CI) 1.28-2.0) points and the maximum observed NeoMODS increased by 1.25 (CI 0.94-1.57) points. The odds for mortality increased by 2.3 (CI 1.14-13.67) per 10 percentage point increase of aortic steal. There was a correlation between aortic steal and cerebral damage at baseline (white matter ρ (rho)=0.34, grey matter ρ=0.81) and follow-up (white matter ρ=0.80, gray matter ρ=0.72). Conclusion The degree of aortic steal in neonates with VGAM was highly associated with the severity of organ dysfunction, disease progression on cMRI, and mortality.
DOI: 10.6084/m9.figshare.5194798.v3
title: BBC words

description: A dictionary of words according to frequency from the run on the BBC between the years 2012-2015<br>
DOI: 10.6084/m9.figshare.21085150.v1
title: Nutrient enrichment promotes invasion success of alien plants via increased growth and suppression of chemical defence

description: Data from: Nutrient enrichment promotes invasion success of alien plants via increased growth and suppression of chemical defence
DOI: 10.6084/m9.figshare.28540421
title: Updating the machine rate costing approach for forest harvesting machines in the southeastern United States

description: The machine-rate methodology provides a basis for estimating the total hourly costs to own and operate logging equipment and comprises fixed, variable, and labor costs. The calculations form a simple approach to estimate machine costs and evaluate new machine alternatives consistently. The methodology has been used extensively since its development in 1942 with periodic updates. The machine-rate method has been widely cited and is regularly used by researchers, logging contractors, harvest managers, and procurement foresters. Since the last update in 2002, machine manufacturers, purchase prices, operating costs, and data sources have changed significantly. Therefore, the objective of this study was to update and modernize the methodology using current machinery, assumptions, and inputs to improve its accuracy and usability. Machine-rate inputs including interest rates, purchase prices, economic life, repair and maintenance, fuel consumption, and lubrication cost were collected for 123 unique machines from whole-tree and cut-to-length equipment dealers in the southeastern United States. In addition, empirical data were used to provide estimates for variables that previously relied on rules of thumb. Finally, guidance was provided to enable users to update assumptions with publicly available information. Prospective users can view and download the updated costing approach spreadsheet in the Supplementary Material linked to this article online.
DOI: 10.6084/m9.figshare.28540421.v1
title: Updating the machine rate costing approach for forest harvesting machines in the southeastern United States

description: The machine-rate methodology provides a basis for estimating the total hourly costs to own and operate logging equipment and comprises fixed, variable, and labor costs. The calculations form a simple approach to estimate machine costs and evaluate new machine alternatives consistently. The methodology has been used extensively since its development in 1942 with periodic updates. The machine-rate method has been widely cited and is regularly used by researchers, logging contractors, harvest managers, and procurement foresters. Since the last update in 2002, machine manufacturers, purchase prices, operating costs, and data sources have changed significantly. Therefore, the objective of this study was to update and modernize the methodology using current machinery, assumptions, and inputs to improve its accuracy and usability. Machine-rate inputs including interest rates, purchase prices, economic life, repair and maintenance, fuel consumption, and lubrication cost were collected for 123 unique machines from whole-tree and cut-to-length equipment dealers in the southeastern United States. In addition, empirical data were used to provide estimates for variables that previously relied on rules of thumb. Finally, guidance was provided to enable users to update assumptions with publicly available information. Prospective users can view and download the updated costing approach spreadsheet in the Supplementary Material linked to this article online.
DOI: 10.6084/m9.figshare.3515582.v1
title: Appendix D. Tables and figures showing results of biophysical modeling for the cane toad in Australia.

description: Tables and figures showing results of biophysical modeling for the cane toad in Australia.
DOI: 10.4121/14413958.v1
title: Participatory Value Evaluation for relaxation of COVID-19 measures

description: This dataset contains the response data of the Participatory Value Evaluation experiment conducted to infer the preferences of Dutch citizens for relaxing COVID-19 measures in 2020.
DOI: 10.6084/m9.figshare.20465778.v1
title: Lebreton_BeMunicipalities_No19

description: Administrative Data
DOI: 10.6084/m9.figshare.13369733.v1
title: Data for "Effect of grain shape on quasi-static fluid-fluid displacement in porous media"

description: Simulation results using the Extended Pore Network Model (EPONM) described in the manuscript "Effect of grain shape on quasi-static fluid-fluid displacement in porous media"<br>"outputData.zip" contains the data from EPONM, which can be opened by MATLAB. (5 simulations for each contact angle and particle shape)"sampleDataStructureDescription" describes the data structure of a sample result.<br>For more information, see the manuscript.
DOI: 10.6084/m9.figshare.28703165.v1
title: ANNEXE - ARTICLE RECOMMANDATIONS MEDICALES

description: Ce jeu de données vient constitue les annexes de l'article "La prise en compte des recommandations médicales par le juge en droit de la responsabilité civile", à paraître à la revue Jurimétrie
DOI: 10.6084/m9.figshare.3083842.v1
title: Metabolite BridgeDb ID Mapping Database (20160113)

description: BridgeDb ID mapping database for metabolites, using HMDB 3.6, ChEBI 135, and Wikidata (13 January 2016) as data sources.
DOI: 10.6084/m9.figshare.28327493.v2
title: Plant-level emissions and synergistic control of pollutants and carbon dioxide in China’s cement industry based real-time monitoring data

description: These data represent the emission concentrations, emission factors and absolute emissions of the Chinese cement industry from 2021 to 2023 by different regions, processes, technologies and scales.
DOI: 10.6084/m9.figshare.28566675
title: Evaluation of chloramphenicol derivative N-phenyl 2, 2 dichloroacetamide anticancer and antibacterial properties

description: This study aimed to develop microparticles of N-phenyl-2,2-dichloroacetamide (PDA), a chloramphenicol derivative with potential antibacterial and anticancer properties, to improve drug release and selectivity while reducing toxicity. PDA microparticles were prepared via spray-drying using L-leucine, Trehalose, and Mannitol. The particles were characterized for size, drug release, antibacterial activity, and cytotoxicity against A549 cancer cells and fibroblasts. PDA formulations exhibited controlled release and enhanced selectivity for cancer cells. S1 showed antibacterial activity against S. aureus. L-leucine formulations had reduced toxicity to normal fibroblasts. PDA microparticles offer potential as safer, targeted antibacterial and anticancer therapies, providing controlled release and reduced side effects.
DOI: 10.6084/m9.figshare.28566675.v1
title: Evaluation of chloramphenicol derivative N-phenyl 2, 2 dichloroacetamide anticancer and antibacterial properties

description: This study aimed to develop microparticles of N-phenyl-2,2-dichloroacetamide (PDA), a chloramphenicol derivative with potential antibacterial and anticancer properties, to improve drug release and selectivity while reducing toxicity. PDA microparticles were prepared via spray-drying using L-leucine, Trehalose, and Mannitol. The particles were characterized for size, drug release, antibacterial activity, and cytotoxicity against A549 cancer cells and fibroblasts. PDA formulations exhibited controlled release and enhanced selectivity for cancer cells. S1 showed antibacterial activity against S. aureus. L-leucine formulations had reduced toxicity to normal fibroblasts. PDA microparticles offer potential as safer, targeted antibacterial and anticancer therapies, providing controlled release and reduced side effects.
DOI: 10.6084/m9.figshare.28513671
title: Effective release of <i>Eryngium maritimum</i> L. callus extract via encapsulation in multilayered liposomes for skin delivery

description: This study aimed to evaluate the potential of <i>Eryngium maritimum</i> L. (EM) callus media filtrate (ECMF) for enhanced skin delivery through multilayered liposomes (MLs). ECMF was applied to human skin cells to assess its antioxidant, anti-inflammatory, and skin barrier-enhancing properties. ECMF was encapsulated in MLs to enhance delivery efficiency, creating a formulation called Cellbiome. Clinical trials involving human participants were conducted to compare its effects with traditional formulations, assessing parameters such as skin density, hydration, elasticity, and wrinkle reduction. Cellbiome significantly improved skin density and moisturization, outperforming conventional formulations. ML encapsulation facilitated deeper penetration of active ingredients beyond the stratum corneum, leading to synchronized improvements in multiple skin parameters, including elasticity, wrinkle reduction, and overall skin health. Transcriptomic and metabolomic analyses further confirmed ECMF’s bioactivity and its role in skin improvement. ML-based formulations, such as Cellbiome, offer superior efficacy in skincare applications compared to conventional methods. This study underscores the importance of advanced delivery technologies in cosmetics and highlights the need for further research to optimize the benefits of natural extracts like EM for human skin, potentially advancing dermatological and cosmeceutical applications. 
Healthy skin plays a crucial role in protecting the body, but factors like aging, pollution, and stress can weaken the skin barrier, leading to dryness, wrinkles, and irritation. In this study, we explored the potential benefits of <i>Eryngium maritimum</i> (EM) callus media filtrate (ECMF) for improving skin health. To enhance its absorption into the skin, we encapsulated the extract in protective vesicles called multilayered liposomes (MLs) to create a new formulation, Cellbiome. We tested Cellbiome in <i>in vitro</i> studies and human clinical trials. The results showed that Cellbiome significantly improved skin hydration, density, and elasticity, making the skin appear healthier and reducing wrinkles. The ML technology allowed the active ingredients to penetrate deeper into the skin compared to traditional skincare products, leading to better overall results. Our findings highlight the potential of advanced delivery systems like MLs to improve the effectiveness of natural skincare ingredients. Cellbiome may provide a more effective solution for skin hydration, anti-aging, and overall skin health. Further research could help optimize these benefits and expand their use in dermatology and cosmetics.
DOI: 10.6084/m9.figshare.28513671.v1
title: Effective release of <i>Eryngium maritimum</i> L. callus extract via encapsulation in multilayered liposomes for skin delivery

description: This study aimed to evaluate the potential of <i>Eryngium maritimum</i> L. (EM) callus media filtrate (ECMF) for enhanced skin delivery through multilayered liposomes (MLs). ECMF was applied to human skin cells to assess its antioxidant, anti-inflammatory, and skin barrier-enhancing properties. ECMF was encapsulated in MLs to enhance delivery efficiency, creating a formulation called Cellbiome. Clinical trials involving human participants were conducted to compare its effects with traditional formulations, assessing parameters such as skin density, hydration, elasticity, and wrinkle reduction. Cellbiome significantly improved skin density and moisturization, outperforming conventional formulations. ML encapsulation facilitated deeper penetration of active ingredients beyond the stratum corneum, leading to synchronized improvements in multiple skin parameters, including elasticity, wrinkle reduction, and overall skin health. Transcriptomic and metabolomic analyses further confirmed ECMF’s bioactivity and its role in skin improvement. ML-based formulations, such as Cellbiome, offer superior efficacy in skincare applications compared to conventional methods. This study underscores the importance of advanced delivery technologies in cosmetics and highlights the need for further research to optimize the benefits of natural extracts like EM for human skin, potentially advancing dermatological and cosmeceutical applications. 
Healthy skin plays a crucial role in protecting the body, but factors like aging, pollution, and stress can weaken the skin barrier, leading to dryness, wrinkles, and irritation. In this study, we explored the potential benefits of <i>Eryngium maritimum</i> (EM) callus media filtrate (ECMF) for improving skin health. To enhance its absorption into the skin, we encapsulated the extract in protective vesicles called multilayered liposomes (MLs) to create a new formulation, Cellbiome. We tested Cellbiome in <i>in vitro</i> studies and human clinical trials. The results showed that Cellbiome significantly improved skin hydration, density, and elasticity, making the skin appear healthier and reducing wrinkles. The ML technology allowed the active ingredients to penetrate deeper into the skin compared to traditional skincare products, leading to better overall results. Our findings highlight the potential of advanced delivery systems like MLs to improve the effectiveness of natural skincare ingredients. Cellbiome may provide a more effective solution for skin hydration, anti-aging, and overall skin health. Further research could help optimize these benefits and expand their use in dermatology and cosmetics.
DOI: 10.6084/m9.figshare.28652382
title: Novel nanostructured lipid carriers with lurasidone hydrochloride for intranasal administration for improved bioavailability

description: This research aims to develop nanostructured lipid carriers containing Lurasidone hydrochloride (LH) with Quality by Design (QbD) methodology to enhance its bioavailability, given LH’s low water solubility (0.224 mg/ml) and bioavailability (9–19%). The optimized LH-NLC formulation contains Glyceryl monostearate (GMS) as solid lipid, Caproyl 90 as liquid lipid and co-surfactant, and Tween 80 as surfactant. The hot emulsification method was used to formulate the LH-NLC using a three-factor, three-level Box-Behnken design (BBD)for ascertaining functional relationships between particle size and entrapment efficiency (EE). Particle size, polydispersity index (PDI), zeta potential, surface morphology, percentage EE, and in vitro and ex-vivo release were assessed. Wistar rats were used to estimate plasma drug concentration after LH-NLC administration. The developed formulation exhibited a particle size of 190.98 ± 4.72 nm, zeta potential of + 17.47 mV, and encapsulation efficiency of 94 ± 1.26% w/w. LH-NLCs showed a drug release rate of 95.37% within 24 hours. Intranasal administration of LH-NLCs resulted in 5.16 times higher bioavailability compared to intranasally administered lurasidone. The study successfully applied QbD methodology to develop NLCs for LH with enhanced bioavailability, demonstrating improved drug entrapment and delivery efficacy for treating psychosis.
DOI: 10.6084/m9.figshare.28652382.v1
title: Novel nanostructured lipid carriers with lurasidone hydrochloride for intranasal administration for improved bioavailability

description: This research aims to develop nanostructured lipid carriers containing Lurasidone hydrochloride (LH) with Quality by Design (QbD) methodology to enhance its bioavailability, given LH’s low water solubility (0.224 mg/ml) and bioavailability (9–19%). The optimized LH-NLC formulation contains Glyceryl monostearate (GMS) as solid lipid, Caproyl 90 as liquid lipid and co-surfactant, and Tween 80 as surfactant. The hot emulsification method was used to formulate the LH-NLC using a three-factor, three-level Box-Behnken design (BBD)for ascertaining functional relationships between particle size and entrapment efficiency (EE). Particle size, polydispersity index (PDI), zeta potential, surface morphology, percentage EE, and in vitro and ex-vivo release were assessed. Wistar rats were used to estimate plasma drug concentration after LH-NLC administration. The developed formulation exhibited a particle size of 190.98 ± 4.72 nm, zeta potential of + 17.47 mV, and encapsulation efficiency of 94 ± 1.26% w/w. LH-NLCs showed a drug release rate of 95.37% within 24 hours. Intranasal administration of LH-NLCs resulted in 5.16 times higher bioavailability compared to intranasally administered lurasidone. The study successfully applied QbD methodology to develop NLCs for LH with enhanced bioavailability, demonstrating improved drug entrapment and delivery efficacy for treating psychosis.
DOI: 10.6084/m9.figshare.28388258.v1
title: PPD-Mali Dataset.dta

description: This dataset contains variables that were actually used in the analyses presented in the paper.
DOI: 10.6084/m9.figshare.21258573.v1
title: Murphy et al 2022 data files

description: Data files from "A tool for monitoring cell type specific focused ultrasound neuromodulation and control of chronic epilepsy" Murphy et al 2022 <br>
DOI: 10.6084/m9.figshare.28791851.v1
title: BPPV_data.xlsx

description: This data set includes participants that were retrospectively identified over a six-month period using patient records from an Outpatient Sports Medicine and Rehabilitation clinic that operated in association with a neuro-otolaryngologist in Florida, USA for the purposes of identifying the prevalence of various comorbidities in this sample compared to national estimates.