cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.15468/dl.kemdqc
title: Occurrence Download

description: A dataset containing 82 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is Germany",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 "TaxonKey is Argynnis niobe"
 ]
}

 The dataset includes 82 records from 7 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0028939-250717081556266/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.7910/dvn/0kso1t
title: Dataverse Index

description: The Dataverse Index provides links to all datasets in this repository.
DOI: 10.17632/2wkjsrcjds
title: Restoration of Cellular Homeostasis by Vx-445 Under ER Stress Conditions: Insights from Biochemical and Proteomic Assays _ DARTS 1

description: Endoplasmic reticulum (ER) stress is a patho-physiological condition that plays a central role in the development of various human diseases. Multiple intracellular and extracellular factors can impair protein folding, leading to protein misfolding diseases (PMDs). Cystic fibrosis (CF) is a notable example, whose pharmacological management relies on combinations of modulators—such as the corrector Vx-445, that targets the defect in the cystic fibrosis transmembrane conductance regulator (CFTR). In vitro binding assays so far are unable to demonstrate a direct interaction between the corrector and CFTR in the cellular environment, leaving its precise mechanism of action unresolved. Thus, this study aims to investigate the role of Vx-445 in neuronal cells, following the induction of ER stress with Thapsigargin, a specific inhibitor of the sarcoplasmic/endoplasmic reticulum Ca2+-ATPase (SERCA), by a multi-disciplinary approach involving biochemical assays, label-free and functional proteomics. Our findings revealed that Vx-445 may participate in the regulation of oxidative stress, as evidenced by its ability to reduce intracellular ROS levels. Additionally, it influences calcium homeostasis, as it was able to restore this system to its basal state and it seems to play a role in modulating apoptosis, as indicated by its capacity to lower cytochrome c release. These results were supported by both expression proteomics and DARTS (Drug Affinity Responsive Target Stability) analyses, aimed at identifying the main cellular pathways restored by Vx-445 and potential protein interaction partners. Overall, the findings could improve our understanding of the cellular targets of CFTR modulators and offer new opportunities for drug repurposing strategies.
DOI: 10.17632/2wkjsrcjds.1
title: Restoration of Cellular Homeostasis by Vx-445 Under ER Stress Conditions: Insights from Biochemical and Proteomic Assays _ DARTS 1

description: Endoplasmic reticulum (ER) stress is a patho-physiological condition that plays a central role in the development of various human diseases. Multiple intracellular and extracellular factors can impair protein folding, leading to protein misfolding diseases (PMDs). Cystic fibrosis (CF) is a notable example, whose pharmacological management relies on combinations of modulators—such as the corrector Vx-445, that targets the defect in the cystic fibrosis transmembrane conductance regulator (CFTR). In vitro binding assays so far are unable to demonstrate a direct interaction between the corrector and CFTR in the cellular environment, leaving its precise mechanism of action unresolved. Thus, this study aims to investigate the role of Vx-445 in neuronal cells, following the induction of ER stress with Thapsigargin, a specific inhibitor of the sarcoplasmic/endoplasmic reticulum Ca2+-ATPase (SERCA), by a multi-disciplinary approach involving biochemical assays, label-free and functional proteomics. Our findings revealed that Vx-445 may participate in the regulation of oxidative stress, as evidenced by its ability to reduce intracellular ROS levels. Additionally, it influences calcium homeostasis, as it was able to restore this system to its basal state and it seems to play a role in modulating apoptosis, as indicated by its capacity to lower cytochrome c release. These results were supported by both expression proteomics and DARTS (Drug Affinity Responsive Target Stability) analyses, aimed at identifying the main cellular pathways restored by Vx-445 and potential protein interaction partners. Overall, the findings could improve our understanding of the cellular targets of CFTR modulators and offer new opportunities for drug repurposing strategies.
DOI: 10.15468/dl.arg37j
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "HasGeospatialIssue is false",
 "HasCoordinate is true",
 "OccurrenceStatus is Present",
 "BasisOfRecord is one of (Human Observation, Machine Observation, Occurrence evidence, Observation)",
 "TaxonKey is one of (Falco rupicoloides)",
 "Country is one of (Bermuda, Canada, Greenland, Saint Pierre and Miquelon, United States of America)"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0028942-250717081556266/datasets/export for details.
DOI: 10.17632/vbvh95ft8t
title: Restoration of Cellular Homeostasis by Vx-445 Under ER Stress Conditions: Insights from Biochemical and Proteomic Assays _ DARTS 2

description: Endoplasmic reticulum (ER) stress is a patho-physiological condition that plays a central role in the development of various human diseases. Multiple intracellular and extracellular factors can impair protein folding, leading to protein misfolding diseases (PMDs). Cystic fibrosis (CF) is a notable example, whose pharmacological management relies on combinations of modulators—such as the corrector Vx-445, that targets the defect in the cystic fibrosis transmembrane conductance regulator (CFTR). In vitro binding assays so far are unable to demonstrate a direct interaction between the corrector and CFTR in the cellular environment, leaving its precise mechanism of action unresolved. Thus, this study aims to investigate the role of Vx-445 in neuronal cells, following the induction of ER stress with Thapsigargin, a specific inhibitor of the sarcoplasmic/endoplasmic reticulum Ca2+-ATPase (SERCA), by a multi-disciplinary approach involving biochemical assays, label-free and functional proteomics. Our findings revealed that Vx-445 may participate in the regulation of oxidative stress, as evidenced by its ability to reduce intracellular ROS levels. Additionally, it influences calcium homeostasis, as it was able to restore this system to its basal state and it seems to play a role in modulating apoptosis, as indicated by its capacity to lower cytochrome c release. These results were supported by both expression proteomics and DARTS (Drug Affinity Responsive Target Stability) analyses, aimed at identifying the main cellular pathways restored by Vx-445 and potential protein interaction partners. Overall, the findings could improve our understanding of the cellular targets of CFTR modulators and offer new opportunities for drug repurposing strategies.
This dataset comprises raw data of the second DARTS replicate.
DOI: 10.17632/vbvh95ft8t.1
title: Restoration of Cellular Homeostasis by Vx-445 Under ER Stress Conditions: Insights from Biochemical and Proteomic Assays _ DARTS 2

description: Endoplasmic reticulum (ER) stress is a patho-physiological condition that plays a central role in the development of various human diseases. Multiple intracellular and extracellular factors can impair protein folding, leading to protein misfolding diseases (PMDs). Cystic fibrosis (CF) is a notable example, whose pharmacological management relies on combinations of modulators—such as the corrector Vx-445, that targets the defect in the cystic fibrosis transmembrane conductance regulator (CFTR). In vitro binding assays so far are unable to demonstrate a direct interaction between the corrector and CFTR in the cellular environment, leaving its precise mechanism of action unresolved. Thus, this study aims to investigate the role of Vx-445 in neuronal cells, following the induction of ER stress with Thapsigargin, a specific inhibitor of the sarcoplasmic/endoplasmic reticulum Ca2+-ATPase (SERCA), by a multi-disciplinary approach involving biochemical assays, label-free and functional proteomics. Our findings revealed that Vx-445 may participate in the regulation of oxidative stress, as evidenced by its ability to reduce intracellular ROS levels. Additionally, it influences calcium homeostasis, as it was able to restore this system to its basal state and it seems to play a role in modulating apoptosis, as indicated by its capacity to lower cytochrome c release. These results were supported by both expression proteomics and DARTS (Drug Affinity Responsive Target Stability) analyses, aimed at identifying the main cellular pathways restored by Vx-445 and potential protein interaction partners. Overall, the findings could improve our understanding of the cellular targets of CFTR modulators and offer new opportunities for drug repurposing strategies.
This dataset comprises raw data of the second DARTS replicate.
DOI: 10.15468/dl.6cgtm7
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "HasGeospatialIssue is false",
 "HasCoordinate is true",
 "OccurrenceStatus is Present",
 "BasisOfRecord is one of (Human Observation, Machine Observation, Occurrence evidence, Observation)",
 "TaxonKey is one of (Falco rupicoloides)",
 "Country is one of (Anguilla, Antigua and Barbuda, Argentina, Aruba, Bahamas, Barbados, Belize, Bolivia (Plurinational State of), Bonaire, Sint Eustatius and Saba, Bouvet Island, Brazil, Cayman Islands, Chile, Colombia, Costa Rica, Cuba, Curaçao, Dominica, Dominican Republic, Ecuador, El Salvador, Falkland Islands (Malvinas), French Guiana, Grenada, Guadeloupe, Guatemala, Guyana, Haiti, Honduras, Jamaica, Martinique, Mexico, Montserrat, Nicaragua, Panama, Paraguay, Peru, Puerto Rico, Saint Barthélemy, Saint Kitts and Nevis, Saint Lucia, Saint Martin (French part), Saint Vincent and the Grenadines, Sint Maarten (Dutch part), South Georgia and the South Sandwich Islands, Suriname, Trinidad and Tobago, Turks and Caicos Islands, Uruguay, Venezuela (Bolivarian Republic of), Virgin Islands (British), Virgin Islands (U.S.))"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0028944-250717081556266/datasets/export for details.
DOI: 10.15468/dl.u45pnf
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "HasGeospatialIssue is false",
 "HasCoordinate is true",
 "OccurrenceStatus is Present",
 "BasisOfRecord is one of (Human Observation, Machine Observation, Occurrence evidence, Observation)",
 "TaxonKey is one of (Falco rupicoloides)",
 "Country is one of (Afghanistan, Armenia, Azerbaijan, Bahrain, Bangladesh, Bhutan, Brunei Darussalam, Cambodia, China, Cyprus, Georgia, Hong Kong, India, Indonesia, Iran (Islamic Republic of), Iraq, Israel, Japan, Jordan, Kazakhstan, Korea (Democratic People’s Republic of), Korea, Republic of, Kuwait, Kyrgyzstan, Lao People’s Democratic Republic, Lebanon, Macao, Malaysia, Maldives, Mongolia, Myanmar, Nepal, Oman, Pakistan, Palestine, State of, Philippines, Qatar, Saudi Arabia, Singapore, Sri Lanka, Syrian Arab Republic, Tajikistan, Thailand, Timor-Leste, Türkiye, Turkmenistan, United Arab Emirates, Uzbekistan, Viet Nam, Yemen)"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0028943-250717081556266/datasets/export for details.
DOI: 10.17632/mfpdj9ncf2
title: Restoration of Cellular Homeostasis by Vx-445 Under ER Stress Conditions: Insights from Biochemical and Proteomic Assays _ DARTS 3

description: Endoplasmic reticulum (ER) stress is a patho-physiological condition that plays a central role in the development of various human diseases. Multiple intracellular and extracellular factors can impair protein folding, leading to protein misfolding diseases (PMDs). Cystic fibrosis (CF) is a notable example, whose pharmacological management relies on combinations of modulators—such as the corrector Vx-445, that targets the defect in the cystic fibrosis transmembrane conductance regulator (CFTR). In vitro binding assays so far are unable to demonstrate a direct interaction between the corrector and CFTR in the cellular environment, leaving its precise mechanism of action unresolved. Thus, this study aims to investigate the role of Vx-445 in neuronal cells, following the induction of ER stress with Thapsigargin, a specific inhibitor of the sarcoplasmic/endoplasmic reticulum Ca2+-ATPase (SERCA), by a multi-disciplinary approach involving biochemical assays, label-free and functional proteomics. Our findings revealed that Vx-445 may participate in the regulation of oxidative stress, as evidenced by its ability to reduce intracellular ROS levels. Additionally, it influences calcium homeostasis, as it was able to restore this system to its basal state and it seems to play a role in modulating apoptosis, as indicated by its capacity to lower cytochrome c release. These results were supported by both expression proteomics and DARTS (Drug Affinity Responsive Target Stability) analyses, aimed at identifying the main cellular pathways restored by Vx-445 and potential protein interaction partners. Overall, the findings could improve our understanding of the cellular targets of CFTR modulators and offer new opportunities for drug repurposing strategies.
This dataset comprises raw data of the third DARTS replicate.
DOI: 10.17632/mfpdj9ncf2.1
title: Restoration of Cellular Homeostasis by Vx-445 Under ER Stress Conditions: Insights from Biochemical and Proteomic Assays _ DARTS 3

description: Endoplasmic reticulum (ER) stress is a patho-physiological condition that plays a central role in the development of various human diseases. Multiple intracellular and extracellular factors can impair protein folding, leading to protein misfolding diseases (PMDs). Cystic fibrosis (CF) is a notable example, whose pharmacological management relies on combinations of modulators—such as the corrector Vx-445, that targets the defect in the cystic fibrosis transmembrane conductance regulator (CFTR). In vitro binding assays so far are unable to demonstrate a direct interaction between the corrector and CFTR in the cellular environment, leaving its precise mechanism of action unresolved. Thus, this study aims to investigate the role of Vx-445 in neuronal cells, following the induction of ER stress with Thapsigargin, a specific inhibitor of the sarcoplasmic/endoplasmic reticulum Ca2+-ATPase (SERCA), by a multi-disciplinary approach involving biochemical assays, label-free and functional proteomics. Our findings revealed that Vx-445 may participate in the regulation of oxidative stress, as evidenced by its ability to reduce intracellular ROS levels. Additionally, it influences calcium homeostasis, as it was able to restore this system to its basal state and it seems to play a role in modulating apoptosis, as indicated by its capacity to lower cytochrome c release. These results were supported by both expression proteomics and DARTS (Drug Affinity Responsive Target Stability) analyses, aimed at identifying the main cellular pathways restored by Vx-445 and potential protein interaction partners. Overall, the findings could improve our understanding of the cellular targets of CFTR modulators and offer new opportunities for drug repurposing strategies.
This dataset comprises raw data of the third DARTS replicate.
DOI: 10.17632/v7976rzxbv.1
title: Artificial oyster reefs can restore lost ecosystem function in temperate seagrass habitats

description: Supplementary source data and annotated R code for manuscript titled "Artificial oyster reefs can restore lost ecosystem function in temperate seagrass habitats", currently under consideration at Ecological Applications.
DOI: 10.15468/dl.9jb47y
title: Occurrence Download

description: A dataset containing 451 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Cyrtochilum pardinum"
 ]
}

 The dataset includes 451 records from 44 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0028945-250717081556266/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.qwtn3t
title: Occurrence Download

description: A dataset containing 1288 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Capparis sepiaria",
 "HasCoordinate is true",
 "Geometry POLYGON ((-17.66889 -35.11691, 51.34702 -35.11691, 51.34702 37.62, -17.66889 37.62, -17.66889 -35.11691))"
 ]
}

 The dataset includes 1288 records from 60 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0028946-250717081556266/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.6ucfkw
title: Occurrence Download

description: A dataset containing 17 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Rattus norvegicus",
 "Country is Singapore",
 "HasCoordinate is true"
 ]
}

 The dataset includes 17 records from 2 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0028947-250717081556266/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.5517/ccdc.csd.cc2kwg75
title: CCDC 2379877: Experimental Crystal Structure Determination

description: Related Article: Yan-Li Yang, Ke-Ke Guo, Xue Bai, An-Ge Zhang, Ying Lu, Mao-Chun Zhu, Shu-Xia Liu|2025|Inorg.Chem.Front.|12|4613|doi:10.1039/D5QI00148J
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2lc3tx
title: CCDC 2393969: Experimental Crystal Structure Determination

description: Related Article: Vinícius Glitz, Daniele Cocco Durigon, André Luiz Amorim, Yara Schuvinski Ricken, Adailton João Bortoluzzi, Antonio Luiz Braga, Ebbe Nordlander, Giovanni Finoto Caramori, Rosely Aparecida Peralta|2025|Inorg.Chem.Front.|12|4677|doi:10.1039/D5QI00162E
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5281/zenodo.16324186
title: test666

description: some test
DOI: 10.5517/ccdc.csd.cc2lc3vy
title: CCDC 2393970: Experimental Crystal Structure Determination

description: Related Article: Vinícius Glitz, Daniele Cocco Durigon, André Luiz Amorim, Yara Schuvinski Ricken, Adailton João Bortoluzzi, Antonio Luiz Braga, Ebbe Nordlander, Giovanni Finoto Caramori, Rosely Aparecida Peralta|2025|Inorg.Chem.Front.|12|4677|doi:10.1039/D5QI00162E
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5281/zenodo.16324185
title: test666

description: some test
DOI: 10.5517/ccdc.csd.cc2lc3wz
title: CCDC 2393971: Experimental Crystal Structure Determination

description: Related Article: Vinícius Glitz, Daniele Cocco Durigon, André Luiz Amorim, Yara Schuvinski Ricken, Adailton João Bortoluzzi, Antonio Luiz Braga, Ebbe Nordlander, Giovanni Finoto Caramori, Rosely Aparecida Peralta|2025|Inorg.Chem.Front.|12|4677|doi:10.1039/D5QI00162E
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2lc3x0
title: CCDC 2393972: Experimental Crystal Structure Determination

description: Related Article: Vinícius Glitz, Daniele Cocco Durigon, André Luiz Amorim, Yara Schuvinski Ricken, Adailton João Bortoluzzi, Antonio Luiz Braga, Ebbe Nordlander, Giovanni Finoto Caramori, Rosely Aparecida Peralta|2025|Inorg.Chem.Front.|12|4677|doi:10.1039/D5QI00162E
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2lc3y1
title: CCDC 2393973: Experimental Crystal Structure Determination

description: Related Article: Vinícius Glitz, Daniele Cocco Durigon, André Luiz Amorim, Yara Schuvinski Ricken, Adailton João Bortoluzzi, Antonio Luiz Braga, Ebbe Nordlander, Giovanni Finoto Caramori, Rosely Aparecida Peralta|2025|Inorg.Chem.Front.|12|4677|doi:10.1039/D5QI00162E
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2lzscr
title: CCDC 2412865: Experimental Crystal Structure Determination

description: Related Article: Mei-Ling Ren, Ze-Jiang Xu, Hua-Kai Li, Zi-Ao Qiu, Liang-Han Shen, Xiang Zhang, Chao Shi, Na Wang, Heng-Yun Ye, Le-Ping Miao|2025|Inorg.Chem.Front.|12|4623|doi:10.1039/D5QI00399G
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2lzsds
title: CCDC 2412866: Experimental Crystal Structure Determination

description: Related Article: Mei-Ling Ren, Ze-Jiang Xu, Hua-Kai Li, Zi-Ao Qiu, Liang-Han Shen, Xiang Zhang, Chao Shi, Na Wang, Heng-Yun Ye, Le-Ping Miao|2025|Inorg.Chem.Front.|12|4623|doi:10.1039/D5QI00399G
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.