cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.29408751.v1
title: Cost-effectiveness of immunization strategies to protect infants against respiratory syncytial virus in the Netherlands

description: The European Medicines Agency has authorized two interventions to prevent lower respiratory tract disease due to respiratory syncytial virus (RSV-LRTD) in infants: nirsevimab, a monoclonal antibody, and bivalent stabilized prefusion F subunit maternal vaccine (RSVpreF). In the Netherlands, RSV-LRTD protection is recommended for all infants with nirsevimab given preferential recommendation over RSVpreF. We evaluated cost-effectiveness of various intervention strategies to prevent RSV in the Netherlands. We employed a cohort model to evaluate clinical and economic outcomes associated with RSV-LRTD during the first year of life among infants receiving RSVpreF with complementary nirsevimab and, alternatively, nirsevimab alone versus no intervention. Model inputs, based principally on Dutch data, include rates of disease, case-fatality, general mortality; disutility; and costs of interventions, medical care, treatment-related travel, and disease-associated work loss. Uptake of interventions assumed 70%; effectiveness was based on a published study using Phase III trial data. Analyses were conducted from the societal perspective using 2023 EUR; annual discount rates were 3% for costs and 1.5% for quality-adjusted life-years (QALYs). With no intervention, there were 10,482 RSV-LRTD cases with total associated costs of € 17.4M. Nirsevimab alone prevented 4,905 cases, yielding 100 QALYs; total costs increased by € 59.3M due to high intervention costs and cost-effectiveness was € 592,404/QALY (vs. no intervention). RSVpreF with complementary nirsevimab for infants prevented 4,723 cases, yielding 108 QALYs; total costs increased by € 35.5M and cost-effectiveness was € 329,187/QALY (vs. no intervention). Maternal RSVpreF with complementary nirsevimab was more cost-effective than nirsevimab alone.
DOI: 10.6084/m9.figshare.28350476.v1
title: Profile of <i>Chlamydia</i> vaccine research: A bibliometric analysis

description: Vaccination is the most effective measure to prevent <i>Chlamydia</i> infection. However, to date, no vaccine has successfully completed the rigorous clinical trial process and gained regulatory approval for use in clinical practice. Scholars have been working on a safe and effective <i>Chlamydia</i> vaccine. In order to better grasp, the global frontiers and development trends in this field, a comprehensive bibliometric analysis was carried out. A total of 234 publications closely regarding <i>Chlamydia</i> vaccines were culled from the Web of Science Core Collection database, and the bibliometric information was then extracted with CiteSpace and VOSviewer software. After measurement analysis, the most influential papers were identified in this area, including highly cited papers, references with strong citation burst, and high co-citated papers. <i>Vaccine</i> has published the most literature on <i>Chlamydia</i> vaccines. Only scholars from 39 countries/regions have been engaged in studying <i>Chlamydia</i> vaccines. The USA is the most prolific country and has the highest collaborative strength. The current research area has focused on protective immunity and immunopathological response. Major outer membrane protein (MOMP) is the most common target vaccine antigen. This study reveals the status of literature and highlights emerging trends in this field, which helps researchers seek insights into this area and serve as a reference guide for further investigations.
DOI: 10.6084/m9.figshare.29986936
title: Assessment of the impact of vaccine literacy on influenza vaccination practices among asthma patients in Jordan

description: Patients with asthma are at increased risk of respiratory infections, especially from seasonal influenza. Vaccination is critical for disease management, but uptake remains low, particularly in low- and middle-income countries. Vaccine literacy (VL) may influence vaccination behavior. This study aimed to assess VL among asthmatic adults in Jordan and examine its relationship with influenza vaccination, considering demographic, attitudinal, and clinical factors. A cross-sectional survey was conducted with 400 adults with asthma. Participants completed the Arabic version of the Vaccine Literacy Assessment tool (HLVa-Ar), a vaccine attitude scale, a vaccination practices survey, a sociodemographic sheet, and the GINA asthma symptoms test. Binary logistic regression identified predictors of influenza vaccination. The results indicated that only 29.1% of participants reported receiving the influenza vaccine. The median VL score was 34 (IQR: 27–41) out of a maximum score of 56. Regression analysis showed that higher VL scores were significantly associated with increased odds of vaccination (OR = 1.053, 95% CI: 1.024–1.083, p &lt;.001). A more positive attitude toward vaccination also predicted higher vaccination rates (OR = 1.286, 95% CI: 1.167–1.418, p &lt;.001). Conversely, participants earning less than 500 JOD per month were less likely to be vaccinated (OR = 0.450, 95% CI: 0.257–0.787, p = .005). The results confirmed that VL significantly influences vaccination practices. Public health strategies should focus on improving VL, especially among socioeconomically disadvantaged groups, to enhance vaccine uptake and asthma control.
DOI: 10.6084/m9.figshare.29986936.v1
title: Assessment of the impact of vaccine literacy on influenza vaccination practices among asthma patients in Jordan

description: Patients with asthma are at increased risk of respiratory infections, especially from seasonal influenza. Vaccination is critical for disease management, but uptake remains low, particularly in low- and middle-income countries. Vaccine literacy (VL) may influence vaccination behavior. This study aimed to assess VL among asthmatic adults in Jordan and examine its relationship with influenza vaccination, considering demographic, attitudinal, and clinical factors. A cross-sectional survey was conducted with 400 adults with asthma. Participants completed the Arabic version of the Vaccine Literacy Assessment tool (HLVa-Ar), a vaccine attitude scale, a vaccination practices survey, a sociodemographic sheet, and the GINA asthma symptoms test. Binary logistic regression identified predictors of influenza vaccination. The results indicated that only 29.1% of participants reported receiving the influenza vaccine. The median VL score was 34 (IQR: 27–41) out of a maximum score of 56. Regression analysis showed that higher VL scores were significantly associated with increased odds of vaccination (OR = 1.053, 95% CI: 1.024–1.083, p &lt;.001). A more positive attitude toward vaccination also predicted higher vaccination rates (OR = 1.286, 95% CI: 1.167–1.418, p &lt;.001). Conversely, participants earning less than 500 JOD per month were less likely to be vaccinated (OR = 0.450, 95% CI: 0.257–0.787, p = .005). The results confirmed that VL significantly influences vaccination practices. Public health strategies should focus on improving VL, especially among socioeconomically disadvantaged groups, to enhance vaccine uptake and asthma control.
DOI: 10.6084/m9.figshare.28350476
title: Profile of <i>Chlamydia</i> vaccine research: A bibliometric analysis

description: Vaccination is the most effective measure to prevent <i>Chlamydia</i> infection. However, to date, no vaccine has successfully completed the rigorous clinical trial process and gained regulatory approval for use in clinical practice. Scholars have been working on a safe and effective <i>Chlamydia</i> vaccine. In order to better grasp, the global frontiers and development trends in this field, a comprehensive bibliometric analysis was carried out. A total of 234 publications closely regarding <i>Chlamydia</i> vaccines were culled from the Web of Science Core Collection database, and the bibliometric information was then extracted with CiteSpace and VOSviewer software. After measurement analysis, the most influential papers were identified in this area, including highly cited papers, references with strong citation burst, and high co-citated papers. <i>Vaccine</i> has published the most literature on <i>Chlamydia</i> vaccines. Only scholars from 39 countries/regions have been engaged in studying <i>Chlamydia</i> vaccines. The USA is the most prolific country and has the highest collaborative strength. The current research area has focused on protective immunity and immunopathological response. Major outer membrane protein (MOMP) is the most common target vaccine antigen. This study reveals the status of literature and highlights emerging trends in this field, which helps researchers seek insights into this area and serve as a reference guide for further investigations.
DOI: 10.6084/m9.figshare.29573459
title: Adverse events following 9-valent human papillomavirus vaccine (GARDASIL® 9) reported to the Vaccine Adverse Event Reporting System (VAERS), 2015–2024

description: GARDASIL 9, a 9-valent HPV vaccine approved in 2014, is widely administered for the prevention of HPV-related malignancies. Although clinical trials demonstrated a favorable safety profile, rare or delayed-onset adverse events may not be captured pre-licensure. Post-marketing surveillance using VAERS offers a complementary approach for signal detection and safety monitoring. We conducted a retrospective pharmacovigilance analysis of VAERS reports following GARDASIL 9 administration from January 1, 2015 to December 31, 2024. Adverse events were encoded using MedDRA v26.0 and categorized by System Organ Class. Disproportionality analyses using four independent algorithms (ROR, PRR, IC, EBGM) were applied to identify positive safety signals. Subgroup assessments included serious reports, death reports, and reports in pregnant individuals. Among reported events, most were non-serious and consistent with known reactogenicity patterns, including syncope, headache, and injection site reactions. However, signals were also detected for certain events not listed in product labeling, including postural orthostatic tachycardia syndrome, eye movement disorder, autoimmune thyroiditis, and posture abnormality. In 57 death reports, neurological terms showed signal elevation but lacked consistent etiologic patterns. No positive signals were detected in the 18 pregnancy-associated reports. This VAERS-based analysis supports the established safety of GARDASIL 9 while highlighting rare signals that warrant further investigation. Given the limitations of passive surveillance, integration with active monitoring systems is essential to refine safety profiles and support ongoing public health vaccination efforts.
DOI: 10.6084/m9.figshare.29573459.v1
title: Adverse events following 9-valent human papillomavirus vaccine (GARDASIL® 9) reported to the Vaccine Adverse Event Reporting System (VAERS), 2015–2024

description: GARDASIL 9, a 9-valent HPV vaccine approved in 2014, is widely administered for the prevention of HPV-related malignancies. Although clinical trials demonstrated a favorable safety profile, rare or delayed-onset adverse events may not be captured pre-licensure. Post-marketing surveillance using VAERS offers a complementary approach for signal detection and safety monitoring. We conducted a retrospective pharmacovigilance analysis of VAERS reports following GARDASIL 9 administration from January 1, 2015 to December 31, 2024. Adverse events were encoded using MedDRA v26.0 and categorized by System Organ Class. Disproportionality analyses using four independent algorithms (ROR, PRR, IC, EBGM) were applied to identify positive safety signals. Subgroup assessments included serious reports, death reports, and reports in pregnant individuals. Among reported events, most were non-serious and consistent with known reactogenicity patterns, including syncope, headache, and injection site reactions. However, signals were also detected for certain events not listed in product labeling, including postural orthostatic tachycardia syndrome, eye movement disorder, autoimmune thyroiditis, and posture abnormality. In 57 death reports, neurological terms showed signal elevation but lacked consistent etiologic patterns. No positive signals were detected in the 18 pregnancy-associated reports. This VAERS-based analysis supports the established safety of GARDASIL 9 while highlighting rare signals that warrant further investigation. Given the limitations of passive surveillance, integration with active monitoring systems is essential to refine safety profiles and support ongoing public health vaccination efforts.
DOI: 10.6084/m9.figshare.30360365
title: A multi-disciplinary exploration of the press review of the Italian National Institute of Health during the COVID-19 pandemic

description: This study examines how Italian national newspapers portrayed COVID-19 vaccines during 2020–2021. A corpus of 5,621 articles from seven newspapers, collected via the Italian National Institute of Health’s daily press review, was analyzed with SketchEngine using corpus-assisted discourse methods. Quantitative analysis showed a rise in vaccine-related coverage at the end of 2020 and throughout 2021. Core terms such as vaccino (vaccine) and vaccinazione (vaccination) were frequent, while occasional use of synonyms like serum and antidote risked creating confusion. Qualitative analysis revealed instances of “false balance,” where anti-vaccine views were presented alongside pro-vaccine perspectives as if equally supported by evidence. These findings suggest that even authoritative outlets reproduced reporting practices that may undermine public understanding of vaccines. Greater awareness of such practices, and closer collaboration between health professionals and communication experts, could help improve the quality of health information in the media.
DOI: 10.6084/m9.figshare.30360365.v1
title: A multi-disciplinary exploration of the press review of the Italian National Institute of Health during the COVID-19 pandemic

description: This study examines how Italian national newspapers portrayed COVID-19 vaccines during 2020–2021. A corpus of 5,621 articles from seven newspapers, collected via the Italian National Institute of Health’s daily press review, was analyzed with SketchEngine using corpus-assisted discourse methods. Quantitative analysis showed a rise in vaccine-related coverage at the end of 2020 and throughout 2021. Core terms such as vaccino (vaccine) and vaccinazione (vaccination) were frequent, while occasional use of synonyms like serum and antidote risked creating confusion. Qualitative analysis revealed instances of “false balance,” where anti-vaccine views were presented alongside pro-vaccine perspectives as if equally supported by evidence. These findings suggest that even authoritative outlets reproduced reporting practices that may undermine public understanding of vaccines. Greater awareness of such practices, and closer collaboration between health professionals and communication experts, could help improve the quality of health information in the media.
DOI: 10.15468/dl.k9sxpd
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Campylocia araca",
 "DecimalLatitude is not null",
 "DecimalLongitude is not null"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0032012-260208012135463/datasets/export for details.
DOI: 10.6084/m9.figshare.29107570
title: The role of nursing in enhancing quality of life for lung cancer patients receiving targeted and immunotherapy: Challenges, opportunities, and future directions

description: Targeted therapy and immunotherapy are two critical contemporary strategies in the management of lung cancer. Despite their success in extending survival and mitigating symptoms, they introduce complex nursing interventions. This narrative review examines the impact of these treatment strategies on patients’ quality of life, assesses the efficacy of current nursing interventions, and proposes strategies for enhancing future nursing practices. A comprehensive analysis of existing literature, covering studies published between 2014 and 2024 in the databases of WOSCC- SCIE, PubMed, CINAHL, and Embase, underscores the pivotal role of nursing in managing treatment-related adverse effects, delivering psychosocial support, and educating patients. Nevertheless, challenges remain in the areas of nursing staff training, resource allocation, and the limited scope of nursing research. Future directions should focus on the development of individualized care plans, the integration of innovative nursing technologies, and the ongoing enhancement of care quality to optimize nursing practices.
DOI: 10.6084/m9.figshare.28770904
title: Magnitude and durability of ProC6C-AlOH/Matrix-M<sup>tm</sup> vaccine-induced malaria transmission-blocking antibodies in Burkinabe adults from a Phase 1 randomized trial

description: ProC6C is a multi-stage malaria vaccine designed to disrupt parasite transmission and prevent infection by incorporating three parasite proteins (Pfs230-Pro, Pfs48/45-6C, and CSP) in a single vaccine antigen. The Phase 1 clinical trial (PACTR202201848463189) conducted in Burkina Faso, showed ProC6C-AlOH/Matrix-M was safe, well tolerated, immunogenic and generated a functional antibody response to all three constituent antigens at the primary output (D70). As magnitude and durability are central to an efficacious malaria vaccine, analysis was expanded past the initial endpoint, to determine transmission-blocking antibodies (anti-Pfs230 and anti-Pfs48/45-6C) present through D180. Analysis of transmission-reducing activity (TRA) showed 7/20 samples remained biologically active at D180. To identify immune biomarkers for high levels of TRA, the Pfs48/45-6C IgG concentration (calculated relative to the transmission-blocking mAb TB31F) was compared among TRA positive and negative individuals. The magnitude of anti-Pfs48/45-6C IgG had an excellent predictive accuracy (area under the receiver operating curve [ROC AUC] &gt;0.8) with a threshold of 8.7 μg/ml for significant TRA. Additionally, there was significant correlation of TRA and anti-Pfs48/45 epitope I IgG concentration but not significant correlation for anti-Pfs230-Pro IgG, suggesting that vaccine-induced anti-Pfs48/45-6C IgG is the main predictor of TRA. This finding was corroborated by the observation that complement had no effect on TRA in the standard membrane feeding assay (SMFA). Collectively, these efforts confirm the transmission-blocking attributes of ProC6C and suggest that an alternative dosing regimen be evaluated in future clinical trials to improve longevity of functional transmission-reducing antibodies.
DOI: 10.6084/m9.figshare.28770904.v1
title: Magnitude and durability of ProC6C-AlOH/Matrix-M<sup>tm</sup> vaccine-induced malaria transmission-blocking antibodies in Burkinabe adults from a Phase 1 randomized trial

description: ProC6C is a multi-stage malaria vaccine designed to disrupt parasite transmission and prevent infection by incorporating three parasite proteins (Pfs230-Pro, Pfs48/45-6C, and CSP) in a single vaccine antigen. The Phase 1 clinical trial (PACTR202201848463189) conducted in Burkina Faso, showed ProC6C-AlOH/Matrix-M was safe, well tolerated, immunogenic and generated a functional antibody response to all three constituent antigens at the primary output (D70). As magnitude and durability are central to an efficacious malaria vaccine, analysis was expanded past the initial endpoint, to determine transmission-blocking antibodies (anti-Pfs230 and anti-Pfs48/45-6C) present through D180. Analysis of transmission-reducing activity (TRA) showed 7/20 samples remained biologically active at D180. To identify immune biomarkers for high levels of TRA, the Pfs48/45-6C IgG concentration (calculated relative to the transmission-blocking mAb TB31F) was compared among TRA positive and negative individuals. The magnitude of anti-Pfs48/45-6C IgG had an excellent predictive accuracy (area under the receiver operating curve [ROC AUC] &gt;0.8) with a threshold of 8.7 μg/ml for significant TRA. Additionally, there was significant correlation of TRA and anti-Pfs48/45 epitope I IgG concentration but not significant correlation for anti-Pfs230-Pro IgG, suggesting that vaccine-induced anti-Pfs48/45-6C IgG is the main predictor of TRA. This finding was corroborated by the observation that complement had no effect on TRA in the standard membrane feeding assay (SMFA). Collectively, these efforts confirm the transmission-blocking attributes of ProC6C and suggest that an alternative dosing regimen be evaluated in future clinical trials to improve longevity of functional transmission-reducing antibodies.
DOI: 10.6084/m9.figshare.29107570.v1
title: The role of nursing in enhancing quality of life for lung cancer patients receiving targeted and immunotherapy: Challenges, opportunities, and future directions

description: Targeted therapy and immunotherapy are two critical contemporary strategies in the management of lung cancer. Despite their success in extending survival and mitigating symptoms, they introduce complex nursing interventions. This narrative review examines the impact of these treatment strategies on patients’ quality of life, assesses the efficacy of current nursing interventions, and proposes strategies for enhancing future nursing practices. A comprehensive analysis of existing literature, covering studies published between 2014 and 2024 in the databases of WOSCC- SCIE, PubMed, CINAHL, and Embase, underscores the pivotal role of nursing in managing treatment-related adverse effects, delivering psychosocial support, and educating patients. Nevertheless, challenges remain in the areas of nursing staff training, resource allocation, and the limited scope of nursing research. Future directions should focus on the development of individualized care plans, the integration of innovative nursing technologies, and the ongoing enhancement of care quality to optimize nursing practices.
DOI: 10.5281/zenodo.18713127
title: Product Characterization (NMR, HRMS, CHN, GCMS)

description: Data for the project/publication: Alkali-Metal Base Catalysed Electrocyclization of Isoprene Derivatives for Jet Fuel Precursors Synthesis