cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.7284/120735
title: CTD (Conductivity, Temperature, Depth) data collected during research cruise OC1506B using a Sea-Bird SBE-911+ instrument system onboard the platform RV Oceanus

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/120738
title: Fluorometer data collected during research cruise OC1506B using a WET Labs WETStar instrument system onboard the platform RV Oceanus

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/120734
title: GNSS (Global Navigation Satellite System) data collected during research cruise OC1506B using a Ashtech ADU5 instrument system onboard the platform RV Oceanus

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/120739
title: Gyrocompass data collected during research cruise OC1506B using a Sperry MK-37 instrument system onboard the platform RV Oceanus

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7387523
title: Semantic-based Process Mining and Analysis

description: Semantic-based Process Mining and Analysis<i></i><sub></sub><sup></sup><br>What is it about?The work in this research proves that semantic-based process mining and analysis is a useful technique especially in solving some didactic issues and answering some questions with regards to ontology-based methods for automatic discovery of different patterns or behaviours within any given process domain.Why is it important?The work extracts streams of event logs from a any given process execution environment and then describe formats that allows for abstract mining and improved process analysis of the captured data sets and models. Technically, the method makes use of semantic annotations, or better still, process description languages to link elements within the events log and model (e.g. using the case study of the research learning process) with concepts that they represent in an ontology specifically designed for representing the process. The results show that a systemwhich is formally encoded with semantic labelling (annotation), semantic representation(ontology) and semantic reasoning (reasoner) has the capacity to lift the process miningand analysis from the syntactic to a more conceptual level.Dr Kingsley Okoye (Author) University of East London<br><b> </b>
DOI: 10.6084/m9.figshare.7387514
title: When verbs have bugs: lexical and syntactic processing costs of split particle verbs in sentence comprehension

description: German particle verbs consist of a base and a particle, two constituents which occupy separate positions in main clauses, but share one lexical entry. It is still unclear if the combination of particles and bases during sentence comprehension is lexical, syntactic or dual in nature. Using behavioural and ERP measurements, we investigated lexical access and sentence integration of split particle verbs in German two-argument sentences. Our results show that the integration of split particle verbs violating sentence structure or lexical constraints leads to both lexical and syntactic processing difficulty. This extends earlier comparable findings reporting only lexical access difficulties, and suggests that the parse is not immediately abandoned upon encountering a nonexistent particle verb. The integration of grammatical particle verbs assigning lexical case did not lead to measurable processing difficulties. We discuss the impact of this finding for current accounts of the role of lexical case marking in sentence comprehension.
DOI: 10.7284/120741
title: Hygrometer data collected during research cruise OC1506B using a Vaisala HMT300 instrument system onboard the platform RV Oceanus

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7387496
title: Dirofilaria-MSMS.zip

description: Highly modified and immunoactive N-glycans of the canine heartworm, Nature Communications, 2019<br><br>zip archive of mzxml and xls files of MS/MS data on N-glycans from Dirofilaria immitis (Martini et al., 2019).<br><br>The mzxml files are extracted from the Bruker Flexanalysis software for all MALDI-TOF MS/MS shown in the main text and supplement of the manuscript. They are unsmoothed, uncorrected and not recalibrated (internal recalibration was performed for some of the spectra shown in the paper).<br><br>The files are named by figure_number-panel_m/z_retention-time_MSMS with ‘pos’ or ‘neg’ for positive or negative mode for anionic glycans or AEAB in the case of the AEAB-labelled glycans. Otherwise, all parent ions were either [M+H]+ or [M-H]- of pyridylaminated N-glycans.<br><br>mzxml files can be read by relevant freeware, such as mMass (www.mmass.org) or mzxmlViewer (tools.proteomecenter.org/mzXMLViewer.php).<br><br>In the case of LC-MS/MS data, an annotated excel file is included: 2018-11-15 Dogheartworm MIRAGE, including the relevant MIRAGE templates for reporting of ‘minimum information required for a glycomics experiment’.
DOI: 10.6084/m9.figshare.7387523.v2
title: Semantic-based Process Mining and Analysis

description: Semantic-based Process Mining and Analysis<i></i><sub></sub><sup></sup><br>What is it about?The work in this research proves that semantic-based process mining and analysis is a useful technique especially in solving some didactic issues and answering some questions with regards to ontology-based methods for automatic discovery of different patterns or behaviours within any given process domain.Why is it important?The work extracts streams of event logs from a any given process execution environment and then describe formats that allows for abstract mining and improved process analysis of the captured data sets and models. Technically, the method makes use of semantic annotations, or better still, process description languages to link elements within the events log and model (e.g. using the case study of the research learning process) with concepts that they represent in an ontology specifically designed for representing the process. The results show that a systemwhich is formally encoded with semantic labelling (annotation), semantic representation(ontology) and semantic reasoning (reasoner) has the capacity to lift the process miningand analysis from the syntactic to a more conceptual level.Dr Kingsley Okoye (Author) University of East London<br><b> </b>
DOI: 10.7284/120740
title: PTU (Pressure, Temperature, Humidity) data collected during research cruise OC1506B using a Vaisala PTU300 instrument system onboard the platform RV Oceanus

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7387523.v1
title: Semantic-based Process Mining and Analysis

description: Semantic-based Process Mining and Analysis<i></i><sub></sub><sup></sup><br>What is it about?The work in this research proves that semantic-based process mining and analysis is a useful technique especially in solving some didactic issues and answering some questions with regards to ontology-based methods for automatic discovery of different patterns or behaviours within any given process domain.Why is it important?The work extracts streams of event logs from a any given process execution environment and then describe formats that allows for abstract mining and improved process analysis of the captured data sets and models. Technically, the method makes use of semantic annotations, or better still, process description languages to link elements within the events log and model (e.g. using the case study of the research learning process) with concepts that they represent in an ontology specifically designed for representing the process. <br>Dr Kingsley Okoye (Author) University of East London<br><b> </b>
DOI: 10.7284/120742
title: Speedlog data collected during research cruise OC1506B using a Furuno DS-50 instrument system onboard the platform RV Oceanus

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7387460
title: Supplementary Material for: On the Enigma of the Human Neurenteric Canal

description: Existence and biomedical relevance of the neurenteric canal, a transient midline structure during early neurulation in the human embryo, have been controversially discussed for more than a century by embryologists and clinicians alike. In this study, the authors address the long-standing enigma by high-resolution histology and three-dimensional reconstruction using new and historic histological sections of 5 human 17- to 21-day-old embryos and of 2 marmoset monkey embryos of the species <i>Callithrix jacchus</i> at corresponding stages. The neurenteric canal presents itself as the classical vertical connection between the amniotic cavity and the yolk sac cavity and is lined (a) craniolaterally by a horseshoe-shaped “hinge of involuting notochordal cells” within Hensen’s node and (b) caudally by the receding primitive streak epiblast dorsally and by notochordal plate epithelium ventrally, the latter of which covered the (longitudinal) notochordal canal on its ventral side at the preceding stage. Furthermore, asymmetric parachordal <i>nodal</i> expression in <i>Callithrix</i> and morphological asymmetries within the nodes of the other specimens suggest an early non-cilium-dependent left-right symmetry breaking mode previously postulated for other mammals. We conclude that structure and position of the mammalian neurenteric canal support the notion of its homology with the reptilian blastopore as a whole and with a dorsal segment of the blastopore in amphibia. These new features of the neurenteric canal may further clarify the aetiology of foetal malformations such as junctional neurulation defects, neuroendodermal cysts, and the split notochord syndrome.
DOI: 10.7284/120743
title: Water Temperature data collected during research cruise OC1506B using a Sea-Bird SBE-38 instrument system onboard the platform RV Oceanus

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7387460.v1
title: Supplementary Material for: On the Enigma of the Human Neurenteric Canal

description: Existence and biomedical relevance of the neurenteric canal, a transient midline structure during early neurulation in the human embryo, have been controversially discussed for more than a century by embryologists and clinicians alike. In this study, the authors address the long-standing enigma by high-resolution histology and three-dimensional reconstruction using new and historic histological sections of 5 human 17- to 21-day-old embryos and of 2 marmoset monkey embryos of the species <i>Callithrix jacchus</i> at corresponding stages. The neurenteric canal presents itself as the classical vertical connection between the amniotic cavity and the yolk sac cavity and is lined (a) craniolaterally by a horseshoe-shaped “hinge of involuting notochordal cells” within Hensen’s node and (b) caudally by the receding primitive streak epiblast dorsally and by notochordal plate epithelium ventrally, the latter of which covered the (longitudinal) notochordal canal on its ventral side at the preceding stage. Furthermore, asymmetric parachordal <i>nodal</i> expression in <i>Callithrix</i> and morphological asymmetries within the nodes of the other specimens suggest an early non-cilium-dependent left-right symmetry breaking mode previously postulated for other mammals. We conclude that structure and position of the mammalian neurenteric canal support the notion of its homology with the reptilian blastopore as a whole and with a dorsal segment of the blastopore in amphibia. These new features of the neurenteric canal may further clarify the aetiology of foetal malformations such as junctional neurulation defects, neuroendodermal cysts, and the split notochord syndrome.
DOI: 10.7284/124000
title: Timeserver data collected during research cruise OC1506B using a Microsemi SyncServer S350 instrument system onboard the platform RV Oceanus

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/120744
title: Transmissometer data collected during research cruise OC1506B using a WET Labs C-Star instrument system onboard the platform RV Oceanus

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7387430
title: 优酷播放清洗数据.xlsx

description: 优酷播放清洗数据
DOI: 10.6084/m9.figshare.7387427
title: 腾讯视频播放清洗数据

description: 腾讯视频播放清洗数据
DOI: 10.6084/m9.figshare.7387427.v1
title: 腾讯视频播放清洗数据

description: 腾讯视频播放清洗数据
DOI: 10.7284/120745
title: TSG (Thermosalinograph) data collected during research cruise OC1506B using a Sea-Bird SBE-45 instrument system onboard the platform RV Oceanus

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7387424
title: 爱奇艺播放清洗数据

description: 爱奇艺播放清洗数据
DOI: 10.6084/m9.figshare.7387430.v1
title: 优酷播放清洗数据.xlsx

description: 优酷播放清洗数据
DOI: 10.6084/m9.figshare.7387421
title: 搜狐视频播放清洗数据

description: 搜狐视频播放清洗数据
DOI: 10.6084/m9.figshare.7387421.v1
title: 搜狐视频播放清洗数据

description: 搜狐视频播放清洗数据
DOI: 10.7284/120759
title: ADCP (Acoustic Doppler Current Profiler) data collected during research cruise OC1507A using a Hawaii UHDAS instrument system onboard the platform RV Oceanus

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/120748
title: CTD (Conductivity, Temperature, Depth) data collected during research cruise OC1507A using a Sea-Bird SBE-911+ instrument system onboard the platform RV Oceanus

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/120751
title: Fluorometer data collected during research cruise OC1507A using a WET Labs WETStar instrument system onboard the platform RV Oceanus

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7387370
title: NGTAS_NA12878_10ng

description: Fastq files for the NA1278 dilution series from cell free DNA
DOI: 10.7284/120747
title: GNSS (Global Navigation Satellite System) data collected during research cruise OC1507A using a Ashtech ADU5 instrument system onboard the platform RV Oceanus

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7387322
title: CLPO analysis of the 7101 dataset

description: JANPA log files used in the study "The maximum occupancy condition for the localized property-optimized orbitals"<br>
DOI: 10.7284/120752
title: Gyrocompass data collected during research cruise OC1507A using a Sperry MK-37 instrument system onboard the platform RV Oceanus

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7387283
title: Supplementary Material for: Targeting Voltage-Dependent Calcium Channels with Pregabalin Exerts a Direct Neuroprotective Effect in an Animal Model of Multiple Sclerosis

description: <b><i>Background/Aims:</i></b> Multiple sclerosis (MS) is a prototypical autoimmune central nervous system (CNS) disease. Particularly progressive forms of MS (PMS) show significant neuroaxonal damage as consequence of demyelination and neuronal hyperexcitation. Immuno-modulatory treatment strategies are beneficial in relapsing MS (RMS), but mostly fail in PMS. Pregabalin (Lyrica®) is prescribed to MS patients to treat neuropathic pain. Mechanistically, it targets voltage-dependent Ca<sup>2+</sup> channels and reduces harmful neuronal hyperexcitation in mouse epilepsy models. Studies suggest that GABA analogues like pregabalin exert neuroprotective effects in animal models of ischemia and trauma. <b><i>Methods:</i></b> We tested the impact of pregabalin in a mouse model of MS (experimental autoimmune encephalomyelitis, EAE) and performed histological and immunological evaluations as well as intravital two-photon-microscopy of brainstem EAE lesions. <b><i>Results:</i></b> Both prophylactic and therapeutic treatments ameliorated the clinical symptoms of EAE and reduced immune cell infiltration into the CNS. On neuronal level, pregabalin reduced long-term potentiation in hippocampal brain slices indicating an impact on mechanisms of learning and memory. In contrast, T cells, microglia and brain endothelial cells were unaffected by pregabalin. However, we found a direct impact of pregabalin on neurons during CNS inflammation as it reversed the pathological elevation of neuronal intracellular Ca<sup>2+</sup> levels in EAE lesions. <b><i>Conclusion:</i></b> The presented data suggest that pregabalin primarily acts on neuronal Ca<sup>2+</sup> channel trafficking thereby reducing Ca<sup>2+</sup>-mediated cytotoxicity and neuronal damage in an animal model of MS. Future clinical trials need to assess the benefit for neuronal survival by expanding the indication for pregabalin administration to MS patients in further disease phases.
DOI: 10.6084/m9.figshare.7387322.v1
title: CLPO analysis of the 7101 dataset

description: JANPA log files used in the study "The maximum occupancy condition for the localized property-optimized orbitals"<br>
DOI: 10.6084/m9.figshare.7387283.v1
title: Supplementary Material for: Targeting Voltage-Dependent Calcium Channels with Pregabalin Exerts a Direct Neuroprotective Effect in an Animal Model of Multiple Sclerosis

description: <b><i>Background/Aims:</i></b> Multiple sclerosis (MS) is a prototypical autoimmune central nervous system (CNS) disease. Particularly progressive forms of MS (PMS) show significant neuroaxonal damage as consequence of demyelination and neuronal hyperexcitation. Immuno-modulatory treatment strategies are beneficial in relapsing MS (RMS), but mostly fail in PMS. Pregabalin (Lyrica®) is prescribed to MS patients to treat neuropathic pain. Mechanistically, it targets voltage-dependent Ca<sup>2+</sup> channels and reduces harmful neuronal hyperexcitation in mouse epilepsy models. Studies suggest that GABA analogues like pregabalin exert neuroprotective effects in animal models of ischemia and trauma. <b><i>Methods:</i></b> We tested the impact of pregabalin in a mouse model of MS (experimental autoimmune encephalomyelitis, EAE) and performed histological and immunological evaluations as well as intravital two-photon-microscopy of brainstem EAE lesions. <b><i>Results:</i></b> Both prophylactic and therapeutic treatments ameliorated the clinical symptoms of EAE and reduced immune cell infiltration into the CNS. On neuronal level, pregabalin reduced long-term potentiation in hippocampal brain slices indicating an impact on mechanisms of learning and memory. In contrast, T cells, microglia and brain endothelial cells were unaffected by pregabalin. However, we found a direct impact of pregabalin on neurons during CNS inflammation as it reversed the pathological elevation of neuronal intracellular Ca<sup>2+</sup> levels in EAE lesions. <b><i>Conclusion:</i></b> The presented data suggest that pregabalin primarily acts on neuronal Ca<sup>2+</sup> channel trafficking thereby reducing Ca<sup>2+</sup>-mediated cytotoxicity and neuronal damage in an animal model of MS. Future clinical trials need to assess the benefit for neuronal survival by expanding the indication for pregabalin administration to MS patients in further disease phases.
DOI: 10.7284/120754
title: Hygrometer data collected during research cruise OC1507A using a Vaisala HMT300 instrument system onboard the platform RV Oceanus

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7387370.v3
title: NGTAS_NA12878_10ng

description: Fastq files for the NA1278 dilution series from cell free DNA
DOI: 10.6084/m9.figshare.7387370.v2
title: NGTAS_NA12878_10ng

description: Fastq files for the NA1278 dilution series from cell free DNA
DOI: 10.6084/m9.figshare.7387232
title: Supplementary Material for: iTRAQ-Based Differential Proteomic Analysis Reveals the Pathways Associated with Tigecycline Resistance in <b><i>Acinetobacter baumannii</i></b>

description: <b><i>Background/Aims:</i></b> <i>Acinetobacter baumannii</i> is an aerobic and Gram-negative bacterial pathogen with high morbidity and mortality. It remains a serious public health problem arising from its multidrug-resistant and extensive antibiotic resistance spectrum. <b><i>Methods:</i></b> In the present study, iTRAQ coupled with 2D LC-MS/MS was used to evaluate the proteome in standard <i>Acinetobacter baumannii</i> standard strains and tigecycline-resistant strains. <b><i>Results:</i></b> A total of 3639 proteins were identified and 961 proteins were identified to be differentially expressed in tigecycline-resistant <i>Acinetobacter baumannii</i> strains compared to the standard strains. 506 (52.6%) proteins were up-regulated and 455 (47.4%) proteins were down-regulated. Based on the GO enrichment analysis and KEGG pathway analysis, we concluded that most differentially expressed proteins were associated with stress responses, cellular component organization, proteins synthesis, degradation and function. Moreover, β-lactam resistance, the longevity regulating pathway and other related pathways were also involved in the regulation of tigecycline-resistant <i>Acinetobacter baumannii</i>. The differential expression of key proteins were evaluated by transcript analysis using quantitative RT-PCR. <b><i>Conclusion:</i></b> These results may provide new insights into the mechanisms of drug resistance in <i>Acinetobacter baumannii</i>.
DOI: 10.7284/120753
title: PTU (Pressure, Temperature, Humidity) data collected during research cruise OC1507A using a Vaisala PTU300 instrument system onboard the platform RV Oceanus

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7387196
title: Supplementary Material for: Prognostic Value of the Glasgow Prognostic Score or Modified Glasgow Prognostic Score for Patients with Colorectal Cancer Receiving Various Treatments: a Systematic Review and Meta-Analysis

description: <b><i>Background/Aims:</i></b> Increasing evidence indicates that the systemic inflammatory response plays a vital role in carcinogenesis. The Glasgow Prognostic Score or modified Glasgow Prognostic Score (GPS/mGPS) is a novel inflammatory indicator which consists of CRP and albumin. Here, we performed a meta-analysis to evaluate the prognostic value of the GPS/ mGPS in patients with colorectal cancer (CRC) and to assess its consistency in different CRC therapies. <b><i>Methods:</i></b> The electronic databases PubMed, Embase, Scopus, Web of Science, and Cochrane Library were searched from inception through December 2017 for the association between the GPS/mGPS and clinical outcomes. Study characteristics and prognostic data were extracted from each relevant study. Overall survival (OS) and cancer-specific survival (CSS) were considered the primary outcomes, and hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated. The quality of each study was pooled using the random-effects Mantel-Haenszel model. Finally, subgroup analyses were performed to detect the heterogeneity of different CRC treatments. <b><i>Results:</i></b> Thirty-four studies, with a combined total of 8834 patients, were eligible for this meta-analysis. Data on OS and CSS were available in 23 and 22 studies, respectively. By comparing the prognostic values of different levels of the GPS in CRC patients, the summary HRs for OS and CSS were 2.18 (95% CI 1.83-2.60) and 1.82 (95% CI 1.57-2.11), respectively. According to the different tumor stages, the subgroup analyses were stratified by different treatments, including curative or palliative therapy. The results robustly confirmed the prognostic role of the GPS/mGPS. <b><i>Conclusion:</i></b> Our results suggest that the GPS/mGPS is a novel and effective prognostic indicator for the OS and CSS of patients with CRC.