cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.24198666
title: Supplementary Material for: Differing definitions of first-ever stroke influence incidence estimates more than trends: a study using linked administrative data

description: Introduction Researchers apply varying definitions when measuring stroke incidence using administrative data. We aimed to investigate the sensitivity of incidence estimates to varying definitions of stroke and lookback periods, and to provide updated incidence rates and trends for Western Australia (WA). Methods We used linked state-wide hospital and death data from 1985-2017 to identify incident strokes from 2005-2017. A standard definition was applied which included strokes coded as the principal hospital diagnosis or the underlying cause of death, with a 10-year lookback used to clear prevalent cases. Alternative definitions were compared against the standard definition by percentage difference in case numbers. Age-standardised incidence rates were calculated, and age- and sex-adjusted Poisson regression models used to estimate incidence trends. Results The standard definition with a 10-year lookback period captured 31,274 incident strokes. Capture increased by 19.3% when including secondary diagnoses, 4.1% when including nontraumatic subdural and extradural haemorrhage, and 8.1% when including associated causes of death. Excluding death records reduced capture by 11.1%. A 20-year lookback reduced over-ascertainment by 2.0% and a 1-year lookback increased capture by 13.3%. Incidence declined 0.6% annually (95% confidence interval -0.9, -0.3). Annual reductions were similar for most definitions except when death records were excluded (-0.1%, CI -0.4, 0.2) and with the shortest lookback periods (greatest annual reduction). Conclusion Stroke incidence has declined in WA. Differing methods of identifying stroke influence estimates of incidence to a greater extent than estimates of trends. Reductions in stroke incidence over time are primarily driven by declines in hospitalised stroke.
DOI: 10.6084/m9.figshare.24198666.v1
title: Supplementary Material for: Differing definitions of first-ever stroke influence incidence estimates more than trends: a study using linked administrative data

description: Introduction Researchers apply varying definitions when measuring stroke incidence using administrative data. We aimed to investigate the sensitivity of incidence estimates to varying definitions of stroke and lookback periods, and to provide updated incidence rates and trends for Western Australia (WA). Methods We used linked state-wide hospital and death data from 1985-2017 to identify incident strokes from 2005-2017. A standard definition was applied which included strokes coded as the principal hospital diagnosis or the underlying cause of death, with a 10-year lookback used to clear prevalent cases. Alternative definitions were compared against the standard definition by percentage difference in case numbers. Age-standardised incidence rates were calculated, and age- and sex-adjusted Poisson regression models used to estimate incidence trends. Results The standard definition with a 10-year lookback period captured 31,274 incident strokes. Capture increased by 19.3% when including secondary diagnoses, 4.1% when including nontraumatic subdural and extradural haemorrhage, and 8.1% when including associated causes of death. Excluding death records reduced capture by 11.1%. A 20-year lookback reduced over-ascertainment by 2.0% and a 1-year lookback increased capture by 13.3%. Incidence declined 0.6% annually (95% confidence interval -0.9, -0.3). Annual reductions were similar for most definitions except when death records were excluded (-0.1%, CI -0.4, 0.2) and with the shortest lookback periods (greatest annual reduction). Conclusion Stroke incidence has declined in WA. Differing methods of identifying stroke influence estimates of incidence to a greater extent than estimates of trends. Reductions in stroke incidence over time are primarily driven by declines in hospitalised stroke.
DOI: 10.5281/zenodo.10125083
title: Investigación BIbliométrica sobre gestión de sucesiones en empresas familiares

description: Bitácora de Investigación que contiene la estrategia de búsqueda en Scopus, documentos CSV y figuras usadas en artículo de revisión boibliométrica sobre gestión de las sucesiones en empresas familiares
DOI: 10.5281/zenodo.10125084
title: Investigación BIbliométrica sobre gestión de sucesiones en empresas familiares

description: Bitácora de Investigación que contiene la estrategia de búsqueda en Scopus, documentos CSV y figuras usadas en artículo de revisión boibliométrica sobre gestión de las sucesiones en empresas familiares
DOI: 10.6084/m9.figshare.24297028
title: Supplementary Material for: Targeting cartilage miR-195/497 cluster for osteoarthritis treatment regulates the circadian clock

description: Introduction: Osteoarthritis (OA) is the most prevalent and debilitating joint disease without an effective therapeutic option. Multiple risk factors for OA have been identified, including abnormal chondrocyte miRNA secretion and circadian rhythms disruption, both of which have been found to cause progressive damage and loss of articular cartilage. Environmental disruption of circadian rhythms in mice predisposes animals to cartilage injury and OA. Methods: The role of miR-195/497 cluster during OA progression was verified by mouse OA model with intraarticular injection of Agomir and Antagomir. We performed micro-CT analysis, Osteoarthritis Research Society International scores, and histological analysis in mouse knee joints. RNA sequencing was performed on the mouse cartilage cell line to explore the molecular mechanism of the miR-195/497 cluster and proteins in signaling pathway were evaluated using western blot. Senescence associated phenotypes were detected by western blot, senescence β-galactosidase Staining, and immunofluorescence. Results: This study demonstrated that miR-195/497-5p expression is disrupted in OA with senescent chondrocytes. In addition, miR-195/497-5p influenced the circadian rhythm of mice chondrocytes by modulating the expression of the Per2 protein, resulting in the gradual degradation of articular cartilage. We found that the miR-195/497 cluster targets DUSP3 expression. The deletion of the miR-195/497 cluster increased the level of DUSP3 expression and decreased the levels of phosphorylated ERK 1/2 and CREB. Per2 transcription is up-regulated by stimulating CREB and ERK1/2 phosphorylation. Conclusion: Our findings identify a regulatory mechanism connecting chondrocyte miR-195/497-5p to cartilage maintenance and repair and imply that circadian rhythm disturbances affected by miR-195/497-5p are risk factors for age-related joint diseases such as OA
DOI: 10.6084/m9.figshare.24297028.v1
title: Supplementary Material for: Targeting cartilage miR-195/497 cluster for osteoarthritis treatment regulates the circadian clock

description: Introduction: Osteoarthritis (OA) is the most prevalent and debilitating joint disease without an effective therapeutic option. Multiple risk factors for OA have been identified, including abnormal chondrocyte miRNA secretion and circadian rhythms disruption, both of which have been found to cause progressive damage and loss of articular cartilage. Environmental disruption of circadian rhythms in mice predisposes animals to cartilage injury and OA. Methods: The role of miR-195/497 cluster during OA progression was verified by mouse OA model with intraarticular injection of Agomir and Antagomir. We performed micro-CT analysis, Osteoarthritis Research Society International scores, and histological analysis in mouse knee joints. RNA sequencing was performed on the mouse cartilage cell line to explore the molecular mechanism of the miR-195/497 cluster and proteins in signaling pathway were evaluated using western blot. Senescence associated phenotypes were detected by western blot, senescence β-galactosidase Staining, and immunofluorescence. Results: This study demonstrated that miR-195/497-5p expression is disrupted in OA with senescent chondrocytes. In addition, miR-195/497-5p influenced the circadian rhythm of mice chondrocytes by modulating the expression of the Per2 protein, resulting in the gradual degradation of articular cartilage. We found that the miR-195/497 cluster targets DUSP3 expression. The deletion of the miR-195/497 cluster increased the level of DUSP3 expression and decreased the levels of phosphorylated ERK 1/2 and CREB. Per2 transcription is up-regulated by stimulating CREB and ERK1/2 phosphorylation. Conclusion: Our findings identify a regulatory mechanism connecting chondrocyte miR-195/497-5p to cartilage maintenance and repair and imply that circadian rhythm disturbances affected by miR-195/497-5p are risk factors for age-related joint diseases such as OA
DOI: 10.6084/m9.figshare.24560173
title: Supporting Information file: Table S1.- PCR stability test during 182.5 generations <i>in vitro</i> conditions to <i>pfhrp2, pfhrp3, pfmal7P1.230, pfmal7P1.228, pfmal13P1.485 </i>and <i>pfmal13P1.475.</i>

description: PCR stability test during 182.5 generations <i>in vitro</i> conditions to <i>pfhrp2, pfhrp3, pfmal7P1.230, pfmal7P1.228, pfmal13P1.485 </i>and <i>pfmal13P1.475 evaluated in Peruvian P.falciparum isolates. </i>Article: Phenotypic and genotypic characterization of <i>Plasmodium falciparum</i> field isolates lacking <i>pfhrp2</i> gene.
DOI: 10.6084/m9.figshare.24560173.v1
title: Supporting Information file: Table S1.- PCR stability test during 182.5 generations <i>in vitro</i> conditions to <i>pfhrp2, pfhrp3, pfmal7P1.230, pfmal7P1.228, pfmal13P1.485 </i>and <i>pfmal13P1.475.</i>

description: PCR stability test during 182.5 generations <i>in vitro</i> conditions to <i>pfhrp2, pfhrp3, pfmal7P1.230, pfmal7P1.228, pfmal13P1.485 </i>and <i>pfmal13P1.475 evaluated in Peruvian P.falciparum isolates. </i>Article: Phenotypic and genotypic characterization of <i>Plasmodium falciparum</i> field isolates lacking <i>pfhrp2</i> gene.
DOI: 10.6084/m9.figshare.24533821
title: Supplementary Material for: Synchronous Primary Lung Cancers Containing Discrete Driver Mutations in a Never Smoker: Case Report

description: Although most lung cancer patients present with one primary cancer, some present with multiple lung cancers of different clonal origin. Timely recognition of synchronous multifocal primary lung cancer (MPLC) enables distinct treatment regimens that reflect the unique genotypic makeup and location of each cancer. However, recognition of synchronous MPLCs is challenging given the prevalence of multifocal disease. Here, we report a case of a patient diagnosed with anaplastic lymphoma kinase positive, termed ALK, metastatic lung adenocarcinoma whose follow up computerized tomography (CT) imaging identified one lesion, present since the patient’s initial presentation, with a distinctly different response to treatment than other lesions. Biopsy results showed a distinct MPLC, an epidermal growth factor receptor-positive (EGFR) adenocarcinoma with no evidence of an ALK mutation. The EGFR lesion was treated with curative intent via surgical resection while the ALK disease was managed with palliative intent via targeted therapy. To our knowledge, there have been no other reports of two synchronous MPLCs of an adenocarcinoma subtype with completely distinct EGFR and ALK driver mutations. This case highlights the importance of serial follow-up imaging, combined with biopsy of lesions with atypical treatment responses, as a method for identifying synchronous MPLCs and adjusting treatment to optimize patient outcomes.
DOI: 10.6084/m9.figshare.24533821.v1
title: Supplementary Material for: Synchronous Primary Lung Cancers Containing Discrete Driver Mutations in a Never Smoker: Case Report

description: Although most lung cancer patients present with one primary cancer, some present with multiple lung cancers of different clonal origin. Timely recognition of synchronous multifocal primary lung cancer (MPLC) enables distinct treatment regimens that reflect the unique genotypic makeup and location of each cancer. However, recognition of synchronous MPLCs is challenging given the prevalence of multifocal disease. Here, we report a case of a patient diagnosed with anaplastic lymphoma kinase positive, termed ALK, metastatic lung adenocarcinoma whose follow up computerized tomography (CT) imaging identified one lesion, present since the patient’s initial presentation, with a distinctly different response to treatment than other lesions. Biopsy results showed a distinct MPLC, an epidermal growth factor receptor-positive (EGFR) adenocarcinoma with no evidence of an ALK mutation. The EGFR lesion was treated with curative intent via surgical resection while the ALK disease was managed with palliative intent via targeted therapy. To our knowledge, there have been no other reports of two synchronous MPLCs of an adenocarcinoma subtype with completely distinct EGFR and ALK driver mutations. This case highlights the importance of serial follow-up imaging, combined with biopsy of lesions with atypical treatment responses, as a method for identifying synchronous MPLCs and adjusting treatment to optimize patient outcomes.
DOI: 10.5519/qd.d9162mz0
title: Query on the Natural History Museum Data Portal (data.nhm.ac.uk) (762 records)
DOI: 10.3886/e192424
title: Data and Code for: A Sufficient Statistics Approach for Macro Policy

description: The evaluation of macroeconomic policy decisions has traditionally relied on the formulation of a specific economic model. In this work, we show that two statistics are sufficient to detect, often even correct, non-optimal policies, i.e., policies that do not minimize the loss function. The two sufficient statistics are (i) forecasts for the policy objectives conditional on the policy choice, and (ii) the impulse responses of the policy objectives to policy shocks. Both statistics can be estimated without relying on a specific structural economic model. We illustrate the method by studying US monetary policy decisions.<br><br>
DOI: 10.5281/zenodo.8386927
title: Atom Probe Tomography dataset of pure Aluminum (Raw data)

description: Atom Probe Tomography dataset of pure Aluminum (Raw data). The experiment was done with Oxcart a custom-made APT instrument. The data was recorded by pyccapt control module.
DOI: 10.3886/e192424v1
title: Data and Code for: A Sufficient Statistics Approach for Macro Policy

description: The evaluation of macroeconomic policy decisions has traditionally relied on the formulation of a specific economic model. In this work, we show that two statistics are sufficient to detect, often even correct, non-optimal policies, i.e., policies that do not minimize the loss function. The two sufficient statistics are (i) forecasts for the policy objectives conditional on the policy choice, and (ii) the impulse responses of the policy objectives to policy shocks. Both statistics can be estimated without relying on a specific structural economic model. We illustrate the method by studying US monetary policy decisions.<br><br>
DOI: 10.6084/m9.figshare.24517093
title: Supplementary Material for: Characterizing Adverse Events of Biologic Treatment of T2 Disease: A Disproportionality Analysis of the FDA Adverse Event Reporting System

description: Introduction: Over the last 3 years, the FDA has approved dupilumab, omalizumab, and mepolizumab for the treatment of CRSwNP; however, adverse events of these biologics have not been described in post-marketing surveillance trials. By utilizing the FDA’s Adverse Event Reporting System (FAERS), this study describes and compares biologic-associated adverse events in T2 disease. Methods: This case-non-case study assessed disproportionate reporting rates using Reporting Odds Ratios (ROR). RORs and p-values for biologic-associated AEs were categorized and compared among dupilumab, omalizumab, and mepolizumab. This analysis included AEs associated with all treatment indications. Relative AE rates and outcomes were calculated. Results: There were a total of 112,560, 24,428, and 18,741 unique AE reports associated with dupilumab, omalizumab, and mepolizumab, respectively. Omalizumab had the strongest association with anaphylaxis (ROR = 20.80, 95% CI 18.58, 23.29). Dupilumab had large relative proportions and positive signals in the ophthalmologic category (7.76%, ROR = 6.20, 95% CI 6.06, 6.35), such as with blurry vision (ROR = 3.80, CI 3.52, 4.12) and visual impairment (ROR = 1.98, CI 1.80, 2.19). Dupilumab was the only biologic associated with injection-site reactions (7.98%, ROR = 8.17, 95% CI 7.98, 8.37). Discussion/Conclusion: This is the first large-scale comparative analysis of the AE profiles of dupilumab, omalizumab, and mepolizumab. Our data suggest possible relations between dupilumab and ophthalmologic and injection-site AEs. Omalizumab was the only biologic with a positive anaphylaxis signal. This FAERS investigation suggests important AE differences among these biologics.
DOI: 10.5281/zenodo.8380629
title: Atom Probe Tomography dataset of pure Aluminum (Raw data)

description: Atom Probe Tomography dataset of pure Aluminum (Raw data). The experiment was done with Oxcart a custom-made APT instrument. The data was recorded by pyccapt control module.
DOI: 10.5281/zenodo.8380630
title: Atom Probe Tomography dataset of pure Aluminum (Raw data)

description: Atom Probe Tomography dataset of pure Aluminum (Raw data). The experiment was done with Oxcart a custom-made APT instrument. The data was recorded by pyccapt control module.
DOI: 10.6084/m9.figshare.24534532
title: Supplementary Material for: A Rare Case of Severe Hypokalemia and Hypomagnesemia due to Venetoclax and Polypharmacy Leading to Life-threatening Cardiac Arrhythmias

description: Venetoclax is a novel agent used in hematologic malignancies. Although no long-term studies have directly implicated Venetoclax, few studies show a possible association with electrolyte abnormalities. Severe derangements in serum electrolyte levels can cause cardiac dysrhythmias, which can be potentially fatal. We present a case of Venetoclax in association with other medications causing life-threatening arrhythmias. Hypothesized mechanisms include damage to the distal tubules causing loss of potassium and magnesium. Our patient required modification of his medications and aggressive repletion of electrolytes with good outcomes. For patients on Venetoclax, especially those with polypharmacy, caution should be exercised to prevent severe electrolyte derangements, which can lead to life-threatening arrhythmias
DOI: 10.6084/m9.figshare.24534532.v1
title: Supplementary Material for: A Rare Case of Severe Hypokalemia and Hypomagnesemia due to Venetoclax and Polypharmacy Leading to Life-threatening Cardiac Arrhythmias

description: Venetoclax is a novel agent used in hematologic malignancies. Although no long-term studies have directly implicated Venetoclax, few studies show a possible association with electrolyte abnormalities. Severe derangements in serum electrolyte levels can cause cardiac dysrhythmias, which can be potentially fatal. We present a case of Venetoclax in association with other medications causing life-threatening arrhythmias. Hypothesized mechanisms include damage to the distal tubules causing loss of potassium and magnesium. Our patient required modification of his medications and aggressive repletion of electrolytes with good outcomes. For patients on Venetoclax, especially those with polypharmacy, caution should be exercised to prevent severe electrolyte derangements, which can lead to life-threatening arrhythmias
DOI: 10.5066/p9r8xxwb
title: Model code, input datasets, and prediction files for dynamic stream dissolved solids and static baseflow dissolved solids SPARROW models of the Upper Colorado River Basin, 1986-2017

description: This data release contains model code and input data for, and predictions from, both a dynamic stream dissolved solids and a static baseflow dissolved solids SPARROW (SPAtially Referenced Regression On Watershed attributes) model of the Upper Colorado River Basin for water years 1986-2017. Input data includes information on dissolved solids sources, landscape transport characteristics, and dissolved solids load calibration data from water quality monitoring stations. Model output includes predictions for every reach of total and incremental predicted loads and total and incremental loads from each source. Further details on model development and results are described in Miller and others, 2023.
DOI: 10.6084/m9.figshare.24534817
title: Supplementary Material for: Marked choroidal thinning observed after intravitreal brolucizumab injection

description: Introduction: Here, we report a case of severe intraocular inflammation (IOI) and prominent choroidal thinning following the initial intravitreal brolucizumab injection (IVBr). Case presentation: The patient was a 75-year-old Japanese man with type 2 age-related macular degeneration of both eyes. Until 2015, he had undergone two intravitreal anti-vascular endothelial growth factor (anti-VEGF) injections and two photodynamic therapies in his right eye. His decimal best-corrected visual acuity was 0.1 in the right and 0.1 in the left eye. Central choroidal thickness (CCT) measured 240 μm in his right eye. IVBr was administered to the right eye. The patient reported pain in the right eye 23 days after the injection. On day 26, panuveitis and retinal vasculitis were observed in the right eye. CCT measured 436 μm. On the same day, a sub-tenon triamcinolone injection was administered. On day 42, retinal inflammation remained at a similar level. The CCT decreased to 164 μm. On day 68, the intraocular pressure (IOP) in the right eye increased to 39 mmHg, and IOI persisted. On day 89, the patient's eye pain disappeared, and the IOP decreased to 13 mmHg. On day 225, the IOI and symptoms were completely resolved. The decimal BCVA was 0.04 in the right eye, and CCT measured 84 μm. Conclusion: Brolucizumab is a highly effective anti-VEGF drug; however, it has the potential to induce inflammation in tissues adjacent to the retina and may occasionally cause irreversible sequelae.
DOI: 10.13012/b2idb-2773204_v2
title: [Redacted]

description: Removed by Illinois Data Bank curators. Contact us for more information. https://databank.illinois.edu/contact
DOI: 10.6084/m9.figshare.24533470
title: Supplementary Material for: Endocavitary right ventricular cardiac metastasis of a lung adenocarcinoma treated by surgery : a novel multimodal therapeutic approach

description: Cardiac metastasis (CM) is a rare lung cancer location. It often remain clinically silent but may cause life threatening complications. Better survival rate thanks to the immunotherapy revolution and the improving performance of imaging lead to an increasing number of CM diagnosis. We report a case of a fifty-four-years old woman who was diagnosed with a stage IIIa non-small cells lung cancer. She developed a right ventricular cardiac metastasis during treatment by immunotherapy after concurrent chemoradiotherapy. Cardiac magnetic resonance imaging concluded to an endocavitary tissular lesion at the RV apex. A surgical complete resection consisting of a right ventriculotomy was performed. Thanks to immunotherapy and more performing imaging, similar cases are more frequent. Our case report also highlights the fact that CM surgery has to be considered as a successful therapeutic option in those oligo-progression situations. Guidelines on the management and treatment of lung cancer CM are needed as well as larger studies to evaluate the benefit from a surgical treatment on the survival rate.