cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.8283281.v3
title: Biological diversity or nomenclatural multiplicity: the Thai freshwater snail <i>Neoradina prasongi</i> Brandt, 1974 (Gastropoda: Thiaridae)

description: A key aspect of evolutionary systematics research is the distinction between nomenclatural multiplicity and biological diversity. Unravelling the latter is only possible by identifying true biological entities, i.e., species and evolutionary lineages instead of an accumulation of nominal taxa. This is particularly difficult to achieve for species with high phenotypic plasticity, such as thiarid freshwater snails, a speciose family notorious for its taxonomic diversity. Exceptionally fraught with problems is a complex of nominal species in the genera <i>Melanoides</i> and <i>Stenomelania.</i> In addition to these genera, morphologically almost indistinguishable shells were the basis for the description of <i>Neoradina prasongi</i> and the establishment of <i>Neoradina.</i> To test whether these shells represent specimens from a distinct evolutionary lineage, we studied representative material of all three genera from Thailand, i.e., <i>Neoradina prasongi</i> and syntopically occurring and/or conchologically similar species, using molecular genetics, shell characters via geometric morphometrics, radula morphology, and reproductive biology. The molecular study of mitochondrial 16S rRNA and COI gene fragments unambiguously supports the distinction of the six species examined, most notably <i>Neoradina prasongi</i> as a distinct lineage. Geometric morphometrics of shell shapes allowed distinguishing species currently assigned to <i>Stenomelania</i> s. str. from the other studied species. Radula characters were uninformative. Our findings confirm the prevalence of different reproductive modes in these viviparous freshwater snails (i.e., the release of larval or juvenile stages). The combined results of our genetic analyses were ambiguous for implications on genus affiliations and did not support the classification of some species as part of <i>Stenomelania</i>, affecting the taxonomic stability of the current conception of these genera. Our results are a crucial first step towards a better understanding of the diversity found within these taxonomically problematic thiarids, emphasizing the need for evolutionary systematics approaches, in order to properly evaluate truly biological diversity in contrast to nomenclatural multiplicity.
DOI: 10.6084/m9.figshare.8283251
title: Posterior Parietal Cortex Plays a Causal Role in Perceptual and Categorical Decisions

description: Contains behavioral and neurophysiological data from Zhou Y. and Freedman D.J. Posterior Parietal Cortex Plays a Causal Role in Perceptual and Categorical Decisions. Science 365: 180-185 (2019)
DOI: 10.6084/m9.figshare.8283281.v2
title: Biological diversity or nomenclatural multiplicity: the Thai freshwater snail <i>Neoradina prasongi</i> Brandt, 1974 (Gastropoda: Thiaridae)

description: A key aspect of evolutionary systematics research is the distinction between nomenclatural multiplicity and biological diversity. Unravelling the latter is only possible by identifying true biological entities, i.e., species and evolutionary lineages instead of an accumulation of nominal taxa. This is particularly difficult to achieve for species with high phenotypic plasticity, such as thiarid freshwater snails, a speciose family notorious for its taxonomic diversity. Exceptionally fraught with problems is a complex of nominal species in the genera <i>Melanoides</i> and <i>Stenomelania.</i> In addition to these genera, morphologically almost indistinguishable shells were the basis for the description of <i>Neoradina prasongi</i> and the establishment of <i>Neoradina.</i> To test whether these shells represent specimens from a distinct evolutionary lineage, we studied representative material of all three genera from Thailand, i.e., <i>Neoradina prasongi</i> and syntopically occurring and/or conchologically similar species, using molecular genetics, shell characters via geometric morphometrics, radula morphology, and reproductive biology. The molecular study of mitochondrial 16S rRNA and COI gene fragments unambiguously supports the distinction of the six species examined, most notably <i>Neoradina prasongi</i> as a distinct lineage. Geometric morphometrics of shell shapes allowed distinguishing species currently assigned to <i>Stenomelania</i> s. str. from the other studied species. Radula characters were uninformative. Our findings confirm the prevalence of different reproductive modes in these viviparous freshwater snails (i.e., the release of larval or juvenile stages). The combined results of our genetic analyses were ambiguous for implications on genus affiliations and did not support the classification of some species as part of <i>Stenomelania</i>, affecting the taxonomic stability of the current conception of these genera. Our results are a crucial first step towards a better understanding of the diversity found within these taxonomically problematic thiarids, emphasizing the need for evolutionary systematics approaches, in order to properly evaluate truly biological diversity in contrast to nomenclatural multiplicity.
DOI: 10.6084/m9.figshare.8283212
title: LS3_3_2.fq.gz

description: A part of transcriptome sequencing data of safflower flowers which were cultivated in different light intensities.
DOI: 10.6084/m9.figshare.8283203
title: LS3_2_2.fq.gz

description: A part of transcriptome sequencing data of safflower flowers which were cultivated in different light intensities.
DOI: 10.6084/m9.figshare.8283188
title: LS3_2_1.fq.gz

description: A part of transcriptome sequencing data of safflower flowers which were cultivated in different light intensities.
DOI: 10.6084/m9.figshare.8283203.v1
title: LS3_2_2.fq.gz

description: A part of transcriptome sequencing data of safflower flowers which were cultivated in different light intensities.
DOI: 10.6084/m9.figshare.8283188.v1
title: LS3_2_1.fq.gz

description: A part of transcriptome sequencing data of safflower flowers which were cultivated in different light intensities.
DOI: 10.6084/m9.figshare.8283176
title: Supplementary Material for: Perinatal Ischemia Alters Global Expression of Synaptosomal Proteins Critical for Neural Plasticity in the Developing Mouse Brain

description: Ischemic perinatal stroke (IPS) affects 1 in 2,300–5,000 live births. Despite a survival rate &gt;95%, approximately 60% of IPS infants develop motor and cognitive impairments. Given the importance of axonal growth and synaptic plasticity in neurocognitive development, our objective was to identify the molecular pathways underlying IPS-associated synaptic dysfunction using a mouse model. IPS was induced by unilateral ligation of the common carotid artery of postnatal day 10 (P10) mice. Five days after ischemia, sensorimotor and motor functions were assessed by vibrissae-evoked forepaw placement and the tail suspension test respectively, showing evidence of greater impairments in male pups than in female pups. Twenty-four hours after ischemia, both hemispheres were collected and synaptosomal proteins then prepared for quantification, using isobaric tags for relative and absolute quantitation. Seventy-two of 1,498 qualified proteins were altered in the ischemic hemisphere. Ingenuity Pathway Analysis was used to map these proteins onto molecular networks indicative of reduced neuronal proliferation, survival, and synaptic plasticity, accompanied by reduced PKCα signaling in male, but not female, pups. These effects also occurred in the non-ischemic hemisphere when compared with sham controls. The altered signaling effects may contribute to the sex-specific neurodevelopmental dysfunction following IPS, highlighting potential pathways for targeting during treatment.
DOI: 10.6084/m9.figshare.8283209
title: LS3_3_1.fq.gz

description: A part of transcriptome sequencing data of safflower flowers which were cultivated in different light intensities.
DOI: 10.6084/m9.figshare.8283086
title: Some new anticancer platinum complexes of dithiocarbamate derivatives against human colorectal and pancreatic cell lines

description: Cisplatin, carboplatin and oxaliplatin and their analogs are effective anticancer agents, but their clinical using is limited by some serious side effects. S,S donor ligands such as dithiocarbamates can be used to reduce some side effects. In this study, some novel water soluble complexes with formula of [Pt(bpy)(R.dtc)]NO<sub>3</sub>, where bpy is bipyridine and R.dtc is amyl-, isopentyl- or tertamyl-dtc (n-pentyl-, 3-metyl-butyl- and 2-methylbutan-dithiocarbamate, respectively) have been synthesized and characterized by elemental analysis, conductivity measurements and chemical analysis. The cytotoxic activities of synthesized complexes were investigated against human adenocarcinoma colorectal cell line (HT29) and human pancreatic cell line (Panc1), and compared with cisplatin and oxaliplatin, which display more anticancer activity for [Pt(bpy)(isopentyl.dtc)]NO<sub>3</sub>. The experimental fluorescence and circular dichroism results illustrated partially groove binding of [Pt(bpy)(amyl.dtc)]NO<sub>3</sub> and [Pt(bpy)isopentyl.dtc)]NO<sub>3</sub> on DNA, while [Pt(bpy)(tertamyl.dtc)]NO<sub>3</sub> complex, can bind to DNA via intercalation. Finally, molecular docking simulation data of DNA interaction with three synthesized complexes showed [Pt(bpy)(amyl.dtc)]NO<sub>3</sub> complex has the highest tendency and negative docking energy in structural change of DNA. Communicated by Ramaswamy H. Sarma
DOI: 10.6084/m9.figshare.8283212.v1
title: LS3_3_2.fq.gz

description: A part of transcriptome sequencing data of safflower flowers which were cultivated in different light intensities.
DOI: 10.6084/m9.figshare.8283176.v1
title: Supplementary Material for: Perinatal Ischemia Alters Global Expression of Synaptosomal Proteins Critical for Neural Plasticity in the Developing Mouse Brain

description: Ischemic perinatal stroke (IPS) affects 1 in 2,300–5,000 live births. Despite a survival rate &gt;95%, approximately 60% of IPS infants develop motor and cognitive impairments. Given the importance of axonal growth and synaptic plasticity in neurocognitive development, our objective was to identify the molecular pathways underlying IPS-associated synaptic dysfunction using a mouse model. IPS was induced by unilateral ligation of the common carotid artery of postnatal day 10 (P10) mice. Five days after ischemia, sensorimotor and motor functions were assessed by vibrissae-evoked forepaw placement and the tail suspension test respectively, showing evidence of greater impairments in male pups than in female pups. Twenty-four hours after ischemia, both hemispheres were collected and synaptosomal proteins then prepared for quantification, using isobaric tags for relative and absolute quantitation. Seventy-two of 1,498 qualified proteins were altered in the ischemic hemisphere. Ingenuity Pathway Analysis was used to map these proteins onto molecular networks indicative of reduced neuronal proliferation, survival, and synaptic plasticity, accompanied by reduced PKCα signaling in male, but not female, pups. These effects also occurred in the non-ischemic hemisphere when compared with sham controls. The altered signaling effects may contribute to the sex-specific neurodevelopmental dysfunction following IPS, highlighting potential pathways for targeting during treatment.
DOI: 10.6084/m9.figshare.8283086.v1
title: Some new anticancer platinum complexes of dithiocarbamate derivatives against human colorectal and pancreatic cell lines

description: Cisplatin, carboplatin and oxaliplatin and their analogs are effective anticancer agents, but their clinical using is limited by some serious side effects. S,S donor ligands such as dithiocarbamates can be used to reduce some side effects. In this study, some novel water soluble complexes with formula of [Pt(bpy)(R.dtc)]NO<sub>3</sub>, where bpy is bipyridine and R.dtc is amyl-, isopentyl- or tertamyl-dtc (n-pentyl-, 3-metyl-butyl- and 2-methylbutan-dithiocarbamate, respectively) have been synthesized and characterized by elemental analysis, conductivity measurements and chemical analysis. The cytotoxic activities of synthesized complexes were investigated against human adenocarcinoma colorectal cell line (HT29) and human pancreatic cell line (Panc1), and compared with cisplatin and oxaliplatin, which display more anticancer activity for [Pt(bpy)(isopentyl.dtc)]NO<sub>3</sub>. The experimental fluorescence and circular dichroism results illustrated partially groove binding of [Pt(bpy)(amyl.dtc)]NO<sub>3</sub> and [Pt(bpy)isopentyl.dtc)]NO<sub>3</sub> on DNA, while [Pt(bpy)(tertamyl.dtc)]NO<sub>3</sub> complex, can bind to DNA via intercalation. Finally, molecular docking simulation data of DNA interaction with three synthesized complexes showed [Pt(bpy)(amyl.dtc)]NO<sub>3</sub> complex has the highest tendency and negative docking energy in structural change of DNA. Communicated by Ramaswamy H. Sarma
DOI: 10.6084/m9.figshare.8283056
title: Iba1 & GAD67 8212 GP 1 mid-CNIC panoramas

description: Iba1 & GAD67 8212 GP 1 mid-CNIC panoramas 2019 paper
DOI: 10.6084/m9.figshare.8282999
title: Iba1 & GAD67 8210 GP 2 VCNIC panoramas

description: Iba1 & GAD67 8210 GP 2 VCNIC panoramas 2019 paper
DOI: 10.6084/m9.figshare.8283056.v1
title: Iba1 & GAD67 8212 GP 1 mid-CNIC panoramas

description: Iba1 & GAD67 8212 GP 1 mid-CNIC panoramas 2019 paper
DOI: 10.6084/m9.figshare.8282999.v1
title: Iba1 & GAD67 8210 GP 2 VCNIC panoramas

description: Iba1 & GAD67 8210 GP 2 VCNIC panoramas 2019 paper
DOI: 10.6084/m9.figshare.8282978
title: Iba1 & GAD67 8210 GP 2 DCIC panoramas

description: Iba1 & GAD67 8210 GP 2 DCIC panoramas 2019 paper
DOI: 10.6084/m9.figshare.8282981
title: Iba1 & GAD67 8210 GP 2 LCIC panoramas

description: Iba1 & GAD67 8210 GP 2 LCIC panoramas 2019 paper
DOI: 10.6084/m9.figshare.8282969
title: Iba1 & GAD67 8210 GP 2 mid-CNIC panoramas

description: Iba1 & GAD67 8210 GP 2 mid-CNIC panoramas 2019 paper
DOI: 10.6084/m9.figshare.8282981.v1
title: Iba1 & GAD67 8210 GP 2 LCIC panoramas

description: Iba1 & GAD67 8210 GP 2 LCIC panoramas 2019 paper
DOI: 10.6084/m9.figshare.8282960
title: Iba1 & GAD67 8210 GP 1 VCNIC panoramas

description: Iba1 & GAD67 8210 GP 1 VCNIC panoramas 2019 paper
DOI: 10.6084/m9.figshare.8282969.v1
title: Iba1 & GAD67 8210 GP 2 mid-CNIC panoramas

description: Iba1 & GAD67 8210 GP 2 mid-CNIC panoramas 2019 paper
DOI: 10.6084/m9.figshare.8282978.v1
title: Iba1 & GAD67 8210 GP 2 DCIC panoramas

description: Iba1 & GAD67 8210 GP 2 DCIC panoramas 2019 paper
DOI: 10.6084/m9.figshare.8282951
title: Iba1 & GAD67 8210 GP 1 LCIC panoramas

description: Iba1 & GAD67 8210 GP 1 LCIC panoramas 2019 paper
DOI: 10.6084/m9.figshare.8282960.v1
title: Iba1 & GAD67 8210 GP 1 VCNIC panoramas

description: Iba1 & GAD67 8210 GP 1 VCNIC panoramas 2019 paper
DOI: 10.6084/m9.figshare.8282930
title: De novo variant in tyrosine kinase SRC causes thrombocytopenia: case report of a second family

description: A germline heterozygous gain-of-function <i>p</i>.E527K variant in tyrosine kinase SRC was previously found to cause thrombocytopenia, myelofibrosis, bleeding, bone pathologies, premature edentulism and mild facial dysmorphia in nine patients of a single pedigree. Because of this variant, SRC loses its self-inhibitory capacity, causing constitutively active SRC expression in platelets. These patients have fewer and heterogeneous-sized platelets that are hyporeactive to collagen. We now report a 5-year-old girl with syndromic thrombocytopenia due to the same SRC-E527K variant that occurs <i>de novo</i>. A bone marrow biopsy, blood smear analysis, platelet aggregations, flow cytometric analysis of <i>P</i>-selectin, SRC expression and tyrosine phosphorylation studies were performed to confirm the similarities between the two families. This study strengthens our previous finding that hyperactive SRC kinase results in mild platelet dysfunction and thrombocytopenia with hypogranular platelets and further expands the clinical description of this syndrome to improve early recognition.
DOI: 10.6084/m9.figshare.8282927
title: Iba1 & GAD67 8210 GP 1 DCIC panoramas

description: Iba1 & GAD67 8210 GP 1 DCIC panoramas 2019 paper
DOI: 10.6084/m9.figshare.8282930.v1
title: De novo variant in tyrosine kinase SRC causes thrombocytopenia: case report of a second family

description: A germline heterozygous gain-of-function <i>p</i>.E527K variant in tyrosine kinase SRC was previously found to cause thrombocytopenia, myelofibrosis, bleeding, bone pathologies, premature edentulism and mild facial dysmorphia in nine patients of a single pedigree. Because of this variant, SRC loses its self-inhibitory capacity, causing constitutively active SRC expression in platelets. These patients have fewer and heterogeneous-sized platelets that are hyporeactive to collagen. We now report a 5-year-old girl with syndromic thrombocytopenia due to the same SRC-E527K variant that occurs <i>de novo</i>. A bone marrow biopsy, blood smear analysis, platelet aggregations, flow cytometric analysis of <i>P</i>-selectin, SRC expression and tyrosine phosphorylation studies were performed to confirm the similarities between the two families. This study strengthens our previous finding that hyperactive SRC kinase results in mild platelet dysfunction and thrombocytopenia with hypogranular platelets and further expands the clinical description of this syndrome to improve early recognition.
DOI: 10.6084/m9.figshare.8282909
title: Iba1 & GAD67 8210 GP 1 mid-CNIC panoramas

description: Iba1 & GAD67 8210 GP 1 mid-CNIC panoramas 2019 paper
DOI: 10.6084/m9.figshare.8282927.v1
title: Iba1 & GAD67 8210 GP 1 DCIC panoramas

description: Iba1 & GAD67 8210 GP 1 DCIC panoramas 2019 paper
DOI: 10.6084/m9.figshare.8282888
title: Iba1 & GAD67 8209 GP 2 VCNIC panoramas

description: Iba1 & GAD67 8209 GP 2 VCNIC panoramas 2019 paper
DOI: 10.6084/m9.figshare.8282888.v1
title: Iba1 & GAD67 8209 GP 2 VCNIC panoramas

description: Iba1 & GAD67 8209 GP 2 VCNIC panoramas 2019 paper
DOI: 10.6084/m9.figshare.8282861
title: Iba1 & GAD67 8209 GP 2 LCIC panoramas

description: Iba1 & GAD67 8209 GP 2 LCIC panoramas 2019 paper
DOI: 10.6084/m9.figshare.8282852
title: Data asymmetries vs performance

description: In this paper we study the relationships between neuromuscular asymmetries and physical performance in youth elite team-sports players.
DOI: 10.6084/m9.figshare.8282861.v1
title: Iba1 & GAD67 8209 GP 2 LCIC panoramas

description: Iba1 & GAD67 8209 GP 2 LCIC panoramas 2019 paper
DOI: 10.6084/m9.figshare.8282852.v2
title: Data asymmetries vs performance

description: In this paper we study the relationships between neuromuscular asymmetries and physical performance in youth elite team-sports players.
DOI: 10.6084/m9.figshare.8282831
title: Iba1 & GAD67 8209 GP 2 DCIC panoramas

description: Iba1 & GAD67 8209 GP 2 DCIC panoramas 2019 paper
DOI: 10.6084/m9.figshare.8282831.v1
title: Iba1 & GAD67 8209 GP 2 DCIC panoramas

description: Iba1 & GAD67 8209 GP 2 DCIC panoramas 2019 paper
DOI: 10.6084/m9.figshare.8282852.v1
title: Data asymmetries vs performance

description: In this paper we study the relationships between neuromuscular asymmetries and physical performance in youth elite team-sports players.
DOI: 10.6084/m9.figshare.8282807
title: Iba1 & GAD67 8209 GP 2 mid-CNIC panoramas

description: Iba1 & GAD67 8209 GP 2 mid-CNIC panoramas 2019 paper
DOI: 10.6084/m9.figshare.8282807.v1
title: Iba1 & GAD67 8209 GP 2 mid-CNIC panoramas

description: Iba1 & GAD67 8209 GP 2 mid-CNIC panoramas 2019 paper
DOI: 10.6084/m9.figshare.8282795
title: Iba1 & GAD67 8209 GP 1 VCNIC panoramas

description: Iba1 & GAD67 8209 GP 1 VCNIC panoramas 2019 paper
DOI: 10.6084/m9.figshare.8282795.v1
title: Iba1 & GAD67 8209 GP 1 VCNIC panoramas

description: Iba1 & GAD67 8209 GP 1 VCNIC panoramas 2019 paper
DOI: 10.6084/m9.figshare.8282783
title: Iba1 & GAD67 8209 GP 1 LCIC panoramas

description: Iba1 & GAD67 8209 GP 1 LCIC panoramas 2019 paper
DOI: 10.6084/m9.figshare.8282771
title: Iba1 & GAD67 8209 GP 1 DCIC panoramas

description: Iba1 & GAD67 8209 GP 1 DCIC panoramas 2019 paper
DOI: 10.6084/m9.figshare.8282783.v1
title: Iba1 & GAD67 8209 GP 1 LCIC panoramas

description: Iba1 & GAD67 8209 GP 1 LCIC panoramas 2019 paper
DOI: 10.6084/m9.figshare.8282747
title: Iba1 & GAD67 8209 GP 1 mid-CNIC panoramas

description: Iba1 & GAD67 8209 GP 1 mid-CNIC panoramas 2019 paper
DOI: 10.6084/m9.figshare.8282771.v2
title: Iba1 & GAD67 8209 GP 1 DCIC panoramas

description: Iba1 & GAD67 8209 GP 1 DCIC panoramas 2019 paper
DOI: 10.6084/m9.figshare.8282744
title: Topic Model and Thematic Coding for Proceedings of the British Society for Research into Learning Mathematics from 2003 to 2018

description: Data file for "UK Mathematics Education Research: what are we talking about, how has this changed, and do we align with international discourse?" consisting of the keyword-groups arising from the survey, the keywords and the 30 topic model topics, their characteristic words and the composition of the Proceedings by topic.
DOI: 10.6084/m9.figshare.8282738
title: Overall skeleton datasheet

description: Overall skeleton datasheet 2019 paper
DOI: 10.6084/m9.figshare.8282771.v1
title: Iba1 & GAD67 8209 GP 1 DCIC panoramas

description: Iba1 & GAD67 8209 GP 1 DCIC panoramas 2019 paper
DOI: 10.6084/m9.figshare.8282744.v1
title: Topic Model and Thematic Coding for Proceedings of the British Society for Research into Learning Mathematics from 2003 to 2018

description: Data file for "UK Mathematics Education Research: what are we talking about, how has this changed, and do we align with international discourse?" consisting of the keyword-groups arising from the survey, the keywords and the 30 topic model topics, their characteristic words and the composition of the Proceedings by topic.
DOI: 10.6084/m9.figshare.8282738.v1
title: Overall skeleton datasheet

description: Overall skeleton datasheet 2019 paper
DOI: 10.6084/m9.figshare.8282702
title: Skeleton analysis 8224 GP 2

description: Skeleton analysis 8224 GP 2 2019 paper
DOI: 10.6084/m9.figshare.8282702.v1
title: Skeleton analysis 8224 GP 2

description: Skeleton analysis 8224 GP 2 2019 paper
DOI: 10.6084/m9.figshare.8282645
title: Skeleton analysis 8224 GP 1

description: Skeleton analysis 8224 GP 1 2019 paper
DOI: 10.6084/m9.figshare.8282645.v1
title: Skeleton analysis 8224 GP 1

description: Skeleton analysis 8224 GP 1 2019 paper
DOI: 10.6084/m9.figshare.8282630
title: Skeleton analysis 8212 GP 2

description: Skeleton analysis 8212 GP 2 2019 paper
DOI: 10.6084/m9.figshare.8282630.v1
title: Skeleton analysis 8212 GP 2

description: Skeleton analysis 8212 GP 2 2019 paper
DOI: 10.6084/m9.figshare.8282597
title: Skeleton analysis 8212 GP 1

description: Skeleton analysis 8212 GP 1 2019 paper
DOI: 10.6084/m9.figshare.8282597.v1
title: Skeleton analysis 8212 GP 1

description: Skeleton analysis 8212 GP 1 2019 paper
DOI: 10.6084/m9.figshare.8282561
title: Skeleton analysis 8210 GP 2

description: Skeleton analysis 8210 GP 2 2019 paper
DOI: 10.6084/m9.figshare.8282561.v1
title: Skeleton analysis 8210 GP 2

description: Skeleton analysis 8210 GP 2 2019 paper