cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.15468/dl.xux2gk
title: Occurrence Download

description: A dataset containing 18 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Musa paradisiaca",
 "Country is Peru",
 "HasCoordinate is true"
 ]
}

 The dataset includes 18 records from 4 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0022305-250920141307145/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.kz8qkf
title: Occurrence Download

description: A dataset containing 67 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Musa paradisiaca",
 "Country is Ecuador",
 "HasCoordinate is true"
 ]
}

 The dataset includes 67 records from 10 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0022302-250920141307145/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.e3pu4n
title: Occurrence Download

description: A dataset containing 142 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Musa paradisiaca",
 "Country is India",
 "HasCoordinate is true"
 ]
}

 The dataset includes 142 records from 7 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0022304-250920141307145/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.6084/m9.figshare.30225148
title: Supplementary Material for: The influence of vertical bitewing radiographs in treatment decision-making for primary molars: a cross-sectional study

description: Aim: The aim of the present study was to evaluate the use of vertical bitewing (VBW) radiographs compared to visual examination alone for caries detection and treatment planning of primary molars in children. Methods: Children aged 5-10 years with high caries risk were examined by trained and calibrated paediatric dentists. Treatment decisions were made based on visual examination alone and after VBW findings and categorised into control (CT), non-restorative treatment (NRT), restorative treatment (RT) and treatment of the necrotic tooth (TNT). Descriptive and statistical analysis was performed using Stata 18.0 (α=5%). Results: A total of 1417 surfaces in 75 children were included in the study (occlusal=528; proximal=889). Radiographic dentine caries lesions were detected in 7% of clinically sound surfaces. Radiographic signs of pulp necrosis were observed in almost 20% of teeth that had no clinical signs of pulp necrosis. This led to significant changes from restorative treatment to pulpectomy/extraction of primary molars. Treatment changes were required for 221 surfaces (15.60%) after radiographic examination (CT to NRT=120; CT to RT=32; NRT to RT=47; RT to TNT=22). Changes were significantly more frequent in proximal surfaces when compared to occlusal ones (p&lt;0.001). Conclusion: VBW increased the detection of proximal caries lesions in primary molars compared to visual examination, however most of those lesions were restricted to enamel. The majority of changes in the treatment decision after radiographic examination occurred from CT to NRT. Vertical bitewings allowed the determination of the depth of dentine caries, proximity to pulp signs of pulp necrosis, and presence of permanent successors, which are essential for treatment planning for deep caries lesions.
DOI: 10.6084/m9.figshare.30225148.v1
title: Supplementary Material for: The influence of vertical bitewing radiographs in treatment decision-making for primary molars: a cross-sectional study

description: Aim: The aim of the present study was to evaluate the use of vertical bitewing (VBW) radiographs compared to visual examination alone for caries detection and treatment planning of primary molars in children. Methods: Children aged 5-10 years with high caries risk were examined by trained and calibrated paediatric dentists. Treatment decisions were made based on visual examination alone and after VBW findings and categorised into control (CT), non-restorative treatment (NRT), restorative treatment (RT) and treatment of the necrotic tooth (TNT). Descriptive and statistical analysis was performed using Stata 18.0 (α=5%). Results: A total of 1417 surfaces in 75 children were included in the study (occlusal=528; proximal=889). Radiographic dentine caries lesions were detected in 7% of clinically sound surfaces. Radiographic signs of pulp necrosis were observed in almost 20% of teeth that had no clinical signs of pulp necrosis. This led to significant changes from restorative treatment to pulpectomy/extraction of primary molars. Treatment changes were required for 221 surfaces (15.60%) after radiographic examination (CT to NRT=120; CT to RT=32; NRT to RT=47; RT to TNT=22). Changes were significantly more frequent in proximal surfaces when compared to occlusal ones (p&lt;0.001). Conclusion: VBW increased the detection of proximal caries lesions in primary molars compared to visual examination, however most of those lesions were restricted to enamel. The majority of changes in the treatment decision after radiographic examination occurred from CT to NRT. Vertical bitewings allowed the determination of the depth of dentine caries, proximity to pulp signs of pulp necrosis, and presence of permanent successors, which are essential for treatment planning for deep caries lesions.
DOI: 10.6084/m9.figshare.30225151
title: Supplementary Material for: Eosinophil-derived neurotoxin is an asthma biomarker linked to wheezing severity in preschool children

description: Background
Novel biomarkers are needed for understanding the clinical characteristics of children with acute wheeze (AW) and for optimizing management strategies. This study investigated serum eosinophil-derived neurotoxin (EDN) and blood eosinophil count (B-Eos) in Japanese pre-school children with current asthma (CA) and/or AW. 
Methods
Two cohorts of Japanese children under 6 years of age were screened for allergy and asthma symptoms using the ISAAC questionnaire and tested for EDN, B-Eos and specific IgE. Cohort 1 included 16 children with CA, 45 with other allergies (OA), e.g. eczema or rhinitis, and 34 healthy controls (HC). Optimal cut-offs (receiver operating characteristic analysis) for EDN and B-Eos were determined for CA vs HC. Cohort 2 included 87 children with AW grouped according to symptom severity, high (EDN-H, B-Eos-H) or low (EDN-L, B-Eos-L) EDN and B-Eos (using the optimal cut-offs) and were followed up during recovery.
Results
Children with CA or OA had higher EDN vs HC (p&lt;0.01). The B-Eos was higher in CA vs HC (p&lt;0.05). The optimal cut-offs for EDN and B-Eos were 26.5 µg/L and 235 cells/µL, respectively. EDN was higher in wheezing children with severe vs mild or moderate symptoms (p&lt;0.05). Conversely, B-Eos were higher in children with mild vs moderate symptoms (p&lt;0.01). EDN decreased in the EDN-H group between AW and recovery (p&lt;0.001). Higher EDN, and to a lesser extent, B-Eos were associated with IgE sensitization.
Conclusion
Serum EDN is a promising exploratory biomarker for CA and AW in pre-school children associated with wheezing severity and recovery after treatment.
DOI: 10.6084/m9.figshare.30225151.v1
title: Supplementary Material for: Eosinophil-derived neurotoxin is an asthma biomarker linked to wheezing severity in preschool children

description: Background
Novel biomarkers are needed for understanding the clinical characteristics of children with acute wheeze (AW) and for optimizing management strategies. This study investigated serum eosinophil-derived neurotoxin (EDN) and blood eosinophil count (B-Eos) in Japanese pre-school children with current asthma (CA) and/or AW. 
Methods
Two cohorts of Japanese children under 6 years of age were screened for allergy and asthma symptoms using the ISAAC questionnaire and tested for EDN, B-Eos and specific IgE. Cohort 1 included 16 children with CA, 45 with other allergies (OA), e.g. eczema or rhinitis, and 34 healthy controls (HC). Optimal cut-offs (receiver operating characteristic analysis) for EDN and B-Eos were determined for CA vs HC. Cohort 2 included 87 children with AW grouped according to symptom severity, high (EDN-H, B-Eos-H) or low (EDN-L, B-Eos-L) EDN and B-Eos (using the optimal cut-offs) and were followed up during recovery.
Results
Children with CA or OA had higher EDN vs HC (p&lt;0.01). The B-Eos was higher in CA vs HC (p&lt;0.05). The optimal cut-offs for EDN and B-Eos were 26.5 µg/L and 235 cells/µL, respectively. EDN was higher in wheezing children with severe vs mild or moderate symptoms (p&lt;0.05). Conversely, B-Eos were higher in children with mild vs moderate symptoms (p&lt;0.01). EDN decreased in the EDN-H group between AW and recovery (p&lt;0.001). Higher EDN, and to a lesser extent, B-Eos were associated with IgE sensitization.
Conclusion
Serum EDN is a promising exploratory biomarker for CA and AW in pre-school children associated with wheezing severity and recovery after treatment.
DOI: 10.6084/m9.figshare.30225154
title: Supplementary Material for: L-Glutamine induced acute kidney injury; a clinical observation.

description: Introduction: 
L-Glutamine is increasingly used as a dietary supplement and its use is, as is the case with other amino acids, considered safe. L-Glutamine is the most abundant amino acid in the human body and is involved in many metabolic reactions. Within the kidney L-Glutamine has an important role in the generation of ammonia and bicarbonate. 

Case presentation: 
We report a case of acute kidney injury (AKI) as a result of tubular damage in a patient who used 18 grams of L-glutamine on a daily basis. Possible mechanisms are proposed of which increased single nephron ammonia production and toxicity seems most likely cause of AKI. 

Conclusion: 
We advise cautious use of L-Glutamine supplements in elderly patient with an already compromised kidney function.
DOI: 10.6084/m9.figshare.30225154.v1
title: Supplementary Material for: L-Glutamine induced acute kidney injury; a clinical observation.

description: Introduction: 
L-Glutamine is increasingly used as a dietary supplement and its use is, as is the case with other amino acids, considered safe. L-Glutamine is the most abundant amino acid in the human body and is involved in many metabolic reactions. Within the kidney L-Glutamine has an important role in the generation of ammonia and bicarbonate. 

Case presentation: 
We report a case of acute kidney injury (AKI) as a result of tubular damage in a patient who used 18 grams of L-glutamine on a daily basis. Possible mechanisms are proposed of which increased single nephron ammonia production and toxicity seems most likely cause of AKI. 

Conclusion: 
We advise cautious use of L-Glutamine supplements in elderly patient with an already compromised kidney function.
DOI: 10.6084/m9.figshare.30225157
title: Supplementary Material for: Potential Role of Aerobic Exercise in Attenuating Diabetic Cardiomyopathy via Modulation of P2X4-Mediated NLRP3 Inflammasome Activation and Pyroptosis

description: Diabetic cardiomyopathy (DCM) is a common diabetic complication associated with chronic low-grade inflammation. Exercise is an effective therapy for DCM, though its mechanisms remain unclear. Here, we demonstrate that exercise mitigates pyroptosis in DCM, potentially by modulating P2X4. Exercise prevented the upregulation of P2X4 and PANX1, inhibited NLRP3 activation, and reduced GSDMD and IL-1β cleavage in DCM mouse hearts, without altering P2X7 levels. In vitro, high glucose alone did not induce significant H9C2 cell death or increase P2X4/P2X7 expression. However, palmitic acid promoted a concentration-dependent increase in P2X4 and NLRP3 expression, caspase-1 activity, and cell necrosis, indicating that lipids drive pyroptosis. A high-fat diet (HFD) model further confirmed a positive correlation between P2X4 expression and NLRP3 activation. Consistent with DCM findings, exercise suppressed P2X4, but not P2X7, in obese mice. Additionally, we observed that exercise and AICAR share a similar mechanism in restraining NLRP3 inflammasome activation by targeting P2X4 and, partially, P2X7, although AICAR did not downregulate P2X7. Overall, our results highlight the critical role of P2X4 in NLRP3-mediated pyroptosis and suggest that exercise ameliorates myocardial inflammation in DCM primarily through P2X4 inhibition.
DOI: 10.6084/m9.figshare.30225157.v1
title: Supplementary Material for: Potential Role of Aerobic Exercise in Attenuating Diabetic Cardiomyopathy via Modulation of P2X4-Mediated NLRP3 Inflammasome Activation and Pyroptosis

description: Diabetic cardiomyopathy (DCM) is a common diabetic complication associated with chronic low-grade inflammation. Exercise is an effective therapy for DCM, though its mechanisms remain unclear. Here, we demonstrate that exercise mitigates pyroptosis in DCM, potentially by modulating P2X4. Exercise prevented the upregulation of P2X4 and PANX1, inhibited NLRP3 activation, and reduced GSDMD and IL-1β cleavage in DCM mouse hearts, without altering P2X7 levels. In vitro, high glucose alone did not induce significant H9C2 cell death or increase P2X4/P2X7 expression. However, palmitic acid promoted a concentration-dependent increase in P2X4 and NLRP3 expression, caspase-1 activity, and cell necrosis, indicating that lipids drive pyroptosis. A high-fat diet (HFD) model further confirmed a positive correlation between P2X4 expression and NLRP3 activation. Consistent with DCM findings, exercise suppressed P2X4, but not P2X7, in obese mice. Additionally, we observed that exercise and AICAR share a similar mechanism in restraining NLRP3 inflammasome activation by targeting P2X4 and, partially, P2X7, although AICAR did not downregulate P2X7. Overall, our results highlight the critical role of P2X4 in NLRP3-mediated pyroptosis and suggest that exercise ameliorates myocardial inflammation in DCM primarily through P2X4 inhibition.
DOI: 10.6084/m9.figshare.30225160
title: Supplementary Material for: Endobronchial Ultrasound-Guided Transbronchial Incision and Resection of Calcified Lymph Nodes: A Minimally Invasive Approach to Airway Stenosis

description: Introduction: Although mediastinal lymph node calcification often remains clinically silent, its compressive effects on vital structures, such as the trachea or bronchi, may necessitate intervention. Traditional surgical resection can be risky for certain patients. We present a pioneering case in which endobronchial ultrasound (EBUS)-guided transbronchial resection effectively relieved bronchial obstruction caused by calcified lymph nodes. 
Case Presentation: A 59-year-old male with a history of treated tuberculosis presented with a 4-month history of persistent cough, sputum, and dyspnea. Imaging revealed calcified mediastinal lymph nodes compressing the right intermediate bronchus, with mucus plug formation and obstructive pneumonia. The patient declined surgery; hence, an EBUS-guided transbronchial resection was performed under general anesthesia. Two calcified lymph nodes were removed using a high-frequency needle knife and forceps under real-time ultrasound guidance. No perioperative complications occurred. The patient's respiratory symptoms resolved, and follow-up bronchoscopy at 4 months showed a fully healed airway without restenosis.
Conclusion: This case highlights the feasibility and safety of EBUS-guided transbronchial resection as a minimally invasive treatment for symptomatic mediastinal lymph node calcification. EBUS has potential as a viable alternative for patients in whom thoracic surgery is contraindicated or declined.
DOI: 10.6084/m9.figshare.30225160.v1
title: Supplementary Material for: Endobronchial Ultrasound-Guided Transbronchial Incision and Resection of Calcified Lymph Nodes: A Minimally Invasive Approach to Airway Stenosis

description: Introduction: Although mediastinal lymph node calcification often remains clinically silent, its compressive effects on vital structures, such as the trachea or bronchi, may necessitate intervention. Traditional surgical resection can be risky for certain patients. We present a pioneering case in which endobronchial ultrasound (EBUS)-guided transbronchial resection effectively relieved bronchial obstruction caused by calcified lymph nodes. 
Case Presentation: A 59-year-old male with a history of treated tuberculosis presented with a 4-month history of persistent cough, sputum, and dyspnea. Imaging revealed calcified mediastinal lymph nodes compressing the right intermediate bronchus, with mucus plug formation and obstructive pneumonia. The patient declined surgery; hence, an EBUS-guided transbronchial resection was performed under general anesthesia. Two calcified lymph nodes were removed using a high-frequency needle knife and forceps under real-time ultrasound guidance. No perioperative complications occurred. The patient's respiratory symptoms resolved, and follow-up bronchoscopy at 4 months showed a fully healed airway without restenosis.
Conclusion: This case highlights the feasibility and safety of EBUS-guided transbronchial resection as a minimally invasive treatment for symptomatic mediastinal lymph node calcification. EBUS has potential as a viable alternative for patients in whom thoracic surgery is contraindicated or declined.
DOI: 10.6084/m9.figshare.30225163
title: Supplementary Material for: Partial-Thickness Corneal Patch Graft with Fibrin Glue for Tube Shunt Exposure - Case Report

description: Introduction: Tube exposure is a serious complication of glaucoma drainage device (GDI) implantation. We describe a novel surgical approach using a partial-thickness corneal patch graft with conjunctival autograft and fibrin glue in a setting of severe conjunctival deficiency.
Case Presentation: We describe a 72-year-old man with chronic angle-closure glaucoma who presented with tube exposure one year after Ahmed valve implantation. Risk factors included diabetes mellitus, a failed trabeculectomy, and prior vitrectomy. The conjunctiva surrounding the exposed tube was ischemic and immobile, and the original corneal patch graft had partially degraded. Revision surgery involved suturing a 4 mm partial-thickness corneal button over the exposed tube, anchored to the residual graft edge and sclera. Due to insufficient mobile conjunctiva, a 4×3 mm conjunctival autograft was harvested from the temporal bulbar conjunctiva and secured with fibrin glue at the border of the corneal button, partially covering it, to promote epithelialization. At one-year follow-up, the tube remained fully covered with no recurrence.
Conclusion: This unique surgical approach using a partial-thickness corneal button and conjunctival autograft offers a viable alternative in cases of tube exposure with severe conjunctival deficiency, where traditional techniques such as conjunctival advancement are not feasible.
DOI: 10.6084/m9.figshare.30225163.v1
title: Supplementary Material for: Partial-Thickness Corneal Patch Graft with Fibrin Glue for Tube Shunt Exposure - Case Report

description: Introduction: Tube exposure is a serious complication of glaucoma drainage device (GDI) implantation. We describe a novel surgical approach using a partial-thickness corneal patch graft with conjunctival autograft and fibrin glue in a setting of severe conjunctival deficiency.
Case Presentation: We describe a 72-year-old man with chronic angle-closure glaucoma who presented with tube exposure one year after Ahmed valve implantation. Risk factors included diabetes mellitus, a failed trabeculectomy, and prior vitrectomy. The conjunctiva surrounding the exposed tube was ischemic and immobile, and the original corneal patch graft had partially degraded. Revision surgery involved suturing a 4 mm partial-thickness corneal button over the exposed tube, anchored to the residual graft edge and sclera. Due to insufficient mobile conjunctiva, a 4×3 mm conjunctival autograft was harvested from the temporal bulbar conjunctiva and secured with fibrin glue at the border of the corneal button, partially covering it, to promote epithelialization. At one-year follow-up, the tube remained fully covered with no recurrence.
Conclusion: This unique surgical approach using a partial-thickness corneal button and conjunctival autograft offers a viable alternative in cases of tube exposure with severe conjunctival deficiency, where traditional techniques such as conjunctival advancement are not feasible.
DOI: 10.6084/m9.figshare.30225166
title: Supplementary Material for: Two Siblings With LRPPRC Mutation: Mitochondrial Complex IV Deficiency: Case Report

description: Objectives: Mitochondrial diseases caused by mutations in the LRPPRC gene are rare and leading to multisystemic dysfunction. We report two siblings from consanguineous Iraqi parents, both harboring a rare homozygous deletion in LRPPRC (c.2726_2728del; p.Lys909del), previously reported in one other patient. These cases contribute to the expanding phenotypic and geographic spectrum of LRPPRC-related mitochondrial disease.
Case presentation: The younger sibling, a 9-year-old girl, presented with severe growth retardation, global developmental delay, hypotonia, spastic ataxic gait and lactic acidosis. MRI showed symmetrical hyperintensities in the mesencephalon and thalami, cerebellar atrophy and an inverted lactate peak on MR spectroscopy. Hypertrophic cardiomyopathy was also detected. The older sibling, aged 13, exhibited milder manifestations including axial hypotonia, tremor, ataxia and persistent hyperlactatemia. Both siblings had elevated lactate levels, but otherwise normal metabolic panels.
Conclusions: These cases highlight the clinical variability of LRPPRC-related disorders. Our report underscores the importance of considering LRPPRC mutations in the differential diagnosis of early-onset neurodevelopmental delay, multisystemic dysfunction with lactic acidosis, especially in populations with high rates of consanguinity. Early genetic diagnosis via whole exome sequencing is essential for accurate diagnosis, genetic counseling and family planning.
DOI: 10.6084/m9.figshare.30225166.v1
title: Supplementary Material for: Two Siblings With LRPPRC Mutation: Mitochondrial Complex IV Deficiency: Case Report

description: Objectives: Mitochondrial diseases caused by mutations in the LRPPRC gene are rare and leading to multisystemic dysfunction. We report two siblings from consanguineous Iraqi parents, both harboring a rare homozygous deletion in LRPPRC (c.2726_2728del; p.Lys909del), previously reported in one other patient. These cases contribute to the expanding phenotypic and geographic spectrum of LRPPRC-related mitochondrial disease.
Case presentation: The younger sibling, a 9-year-old girl, presented with severe growth retardation, global developmental delay, hypotonia, spastic ataxic gait and lactic acidosis. MRI showed symmetrical hyperintensities in the mesencephalon and thalami, cerebellar atrophy and an inverted lactate peak on MR spectroscopy. Hypertrophic cardiomyopathy was also detected. The older sibling, aged 13, exhibited milder manifestations including axial hypotonia, tremor, ataxia and persistent hyperlactatemia. Both siblings had elevated lactate levels, but otherwise normal metabolic panels.
Conclusions: These cases highlight the clinical variability of LRPPRC-related disorders. Our report underscores the importance of considering LRPPRC mutations in the differential diagnosis of early-onset neurodevelopmental delay, multisystemic dysfunction with lactic acidosis, especially in populations with high rates of consanguinity. Early genetic diagnosis via whole exome sequencing is essential for accurate diagnosis, genetic counseling and family planning.