cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.15468/dl.rwqmpj
title: Occurrence Download

description: A dataset containing 139 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Cookeolus japonicus (Cuvier, 1829)",
 "Geometry POLYGON((170 20, 170 50, 120 50, 120 20, 170 20))",
 "HasCoordinate is true"
 ]
}

 The dataset includes 139 records from 20 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0001742-250127130748423/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.swb86h
title: Occurrence Download

description: A dataset containing 38942 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Apricaphanius iberus (Valenciennes, 1846), Apricaphanius baeticus (Doadrio, Carmona & Fernández-Delgado, 2002), Gambusia holbrooki Girard, 1859)",
 "OccurrenceStatus is one of (Present)",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 {
 "not" : {
 "BasisOfRecord" : [
 "is one of (Fossil)"
 ]
 }
 },
 "Year is greater than or equal to 1970"
 ]
}

 The dataset includes 38942 records from 165 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0001741-250127130748423/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.6084/m9.figshare.27179370
title: Efficacy of Topical Cyclosporine Combined with Punctal Plugs in Treating Dry Eye Disease and Inflammation

description: To evaluate the effect of punctal plugs combined with cyclosporine eye drops on dry eye disease (DED) and ocular surface inflammation. In a clinical trial, 73 patients were randomly allocated into three groups: punctal plug group, combination therapy group, and cyclosporine group. At the baseline and four weeks after treatment, the Schirmer I test score, fluorescein tear film break-up time (FBUT), ocular surface staining score and dry eye symptoms were assessed. Tear samples were collected to detect the level of inflammatory factors (interleukins, matrix metalloproteinase 9 (MMP-9) and tumor necrosis factor alpha (TNF-α)). In an animal experiment, a New Zealand rabbit dry eye model was induced. The rabbits were randomly divided into control group, punctal plug group, and combination therapy group (<i>n</i> = 6). Conjunctival goblet cell density, protein level of MMP-9 in conjunctiva and mRNA levels of inflammatory factors in conjunctiva and cornea were measured before and after treatment. In combination therapy group of the clinical trial, the following results were observed: significant improvement in Schirmer I test scores and FBUT compared to the cyclosporine group and punctal plug group, respectively; a decrease in the tear levels of IL-6, IL-1, and MMP-9 compared to the punctal plug group; and a decrease in the tear levels of IL-1α, IL-6, and IL-17 compared to the baseline (all <i>p</i> &lt; 0.05). In the animal experiment, rabbits in combination therapy group had a higher goblet cell density (<i>p</i> &lt; 0.01) and lower mRNA levels of IL-16 (<i>p</i> &lt; 0.05), IL-17 (<i>p</i> &lt; 0.05), and MMP-9 (<i>p</i> &lt; 0.01) in conjunctiva and that of MMP-9 (<i>p</i> &lt; 0.01) in cornea compared to punctal plug group. Cyclosporine eye drops combined with degradable punctal plugs is a more optimized clinical treatment strategy for DED compared with degradable punctal plugs or cyclosporine eye drops alone, considering the influence of comprehensive clinical efficacy and ocular surface inflammation.
DOI: 10.6084/m9.figshare.27179370.v1
title: Efficacy of Topical Cyclosporine Combined with Punctal Plugs in Treating Dry Eye Disease and Inflammation

description: To evaluate the effect of punctal plugs combined with cyclosporine eye drops on dry eye disease (DED) and ocular surface inflammation. In a clinical trial, 73 patients were randomly allocated into three groups: punctal plug group, combination therapy group, and cyclosporine group. At the baseline and four weeks after treatment, the Schirmer I test score, fluorescein tear film break-up time (FBUT), ocular surface staining score and dry eye symptoms were assessed. Tear samples were collected to detect the level of inflammatory factors (interleukins, matrix metalloproteinase 9 (MMP-9) and tumor necrosis factor alpha (TNF-α)). In an animal experiment, a New Zealand rabbit dry eye model was induced. The rabbits were randomly divided into control group, punctal plug group, and combination therapy group (<i>n</i> = 6). Conjunctival goblet cell density, protein level of MMP-9 in conjunctiva and mRNA levels of inflammatory factors in conjunctiva and cornea were measured before and after treatment. In combination therapy group of the clinical trial, the following results were observed: significant improvement in Schirmer I test scores and FBUT compared to the cyclosporine group and punctal plug group, respectively; a decrease in the tear levels of IL-6, IL-1, and MMP-9 compared to the punctal plug group; and a decrease in the tear levels of IL-1α, IL-6, and IL-17 compared to the baseline (all <i>p</i> &lt; 0.05). In the animal experiment, rabbits in combination therapy group had a higher goblet cell density (<i>p</i> &lt; 0.01) and lower mRNA levels of IL-16 (<i>p</i> &lt; 0.05), IL-17 (<i>p</i> &lt; 0.05), and MMP-9 (<i>p</i> &lt; 0.01) in conjunctiva and that of MMP-9 (<i>p</i> &lt; 0.01) in cornea compared to punctal plug group. Cyclosporine eye drops combined with degradable punctal plugs is a more optimized clinical treatment strategy for DED compared with degradable punctal plugs or cyclosporine eye drops alone, considering the influence of comprehensive clinical efficacy and ocular surface inflammation.
DOI: 10.6084/m9.figshare.27093924
title: Temporal Regulation of Myopia and Inflammation-Associated Pathways in the Interphotoreceptor Retinoid-Binding Protein Knockout Mouse Model

description: Myopia is a complex disorder with etiology involving an interplay between several genetic and environmental factors. Interphotoreceptor retinoid-binding protein (IRBP) is found in the subretinal space and is crucial in the visual cycle. The interphotoreceptor retinoid-binding protein knockout mouse (IRBP KO) was established as a model system to understand myopia and retinal degeneration. The current study investigated genes associated with myopia, retinal homeostasis, and inflammation in IRBP KO. RNA from retinas of congenic IRBP KO and wild-type C57BL/6J (WT) mice at postnatal day 5 (P5), P40, and P213 were subjected to digital droplet PCR (ddPCR) using a Bio-Rad automated droplet generator and QX200 reader. Target genes were selected based on genome-wide association studies, animal models, myopia studies, and other genes associated with retinal homeostasis and inflammation. HPRT, a housekeeping gene, was used for normalization. An average expression ratio (target/HPRT) and standard deviation (SD) were calculated. ANOVA assessed statistical significance, and a <i>p</i> &lt; 0.05 was considered significant. The ddPCR data analysis indicated that numerous myopia and inflammation-associated genes were differentially regulated in IRBP KO retinas with distinct temporal variation (upregulated at P5, decreased at P40, and no change at P213 relative to WT). <i>C1qa</i>, <i>Gjd2</i>, <i>Sntb1</i>, and <i>Vsx2</i> emerged as top genetic candidate pathways. Compared with WT, immunoblotting analysis of C1qa showed no significant differences at P5 but significantly increased protein levels at P7 in IRBP KOs. Vsx2 remained unaltered at P5 and P7 in KO when compared with WT. Data analysis indicated significant contributions from <i>C1q</i>, <i>Gjd2</i>, <i>Sntb1</i>, and <i>Vsx2</i> genes in IRBP deficiency.
DOI: 10.6084/m9.figshare.27093924.v1
title: Temporal Regulation of Myopia and Inflammation-Associated Pathways in the Interphotoreceptor Retinoid-Binding Protein Knockout Mouse Model

description: Myopia is a complex disorder with etiology involving an interplay between several genetic and environmental factors. Interphotoreceptor retinoid-binding protein (IRBP) is found in the subretinal space and is crucial in the visual cycle. The interphotoreceptor retinoid-binding protein knockout mouse (IRBP KO) was established as a model system to understand myopia and retinal degeneration. The current study investigated genes associated with myopia, retinal homeostasis, and inflammation in IRBP KO. RNA from retinas of congenic IRBP KO and wild-type C57BL/6J (WT) mice at postnatal day 5 (P5), P40, and P213 were subjected to digital droplet PCR (ddPCR) using a Bio-Rad automated droplet generator and QX200 reader. Target genes were selected based on genome-wide association studies, animal models, myopia studies, and other genes associated with retinal homeostasis and inflammation. HPRT, a housekeeping gene, was used for normalization. An average expression ratio (target/HPRT) and standard deviation (SD) were calculated. ANOVA assessed statistical significance, and a <i>p</i> &lt; 0.05 was considered significant. The ddPCR data analysis indicated that numerous myopia and inflammation-associated genes were differentially regulated in IRBP KO retinas with distinct temporal variation (upregulated at P5, decreased at P40, and no change at P213 relative to WT). <i>C1qa</i>, <i>Gjd2</i>, <i>Sntb1</i>, and <i>Vsx2</i> emerged as top genetic candidate pathways. Compared with WT, immunoblotting analysis of C1qa showed no significant differences at P5 but significantly increased protein levels at P7 in IRBP KOs. Vsx2 remained unaltered at P5 and P7 in KO when compared with WT. Data analysis indicated significant contributions from <i>C1q</i>, <i>Gjd2</i>, <i>Sntb1</i>, and <i>Vsx2</i> genes in IRBP deficiency.
DOI: 10.6084/m9.figshare.28295520
title: Dysfunction of Endothelial Cell-Mediated Intercellular Communication and Metabolic Pathways in Age-Related Macular Degeneration

description: Age-related macular degeneration (AMD) is the leading cause of blindness in the elderly, but the therapies are not satisfactory. This study aimed to find AMD specific features through the analysis of high-throughput sequencing. In this study, we integrated six projects containing single-cell RNA sequencing (scRNA-seq) data to perform a comprehensive analysis for AMD samples in the tissues of retina and retinal pigment epithelium/choroid, and in the positions of macula and periphery. Differentially expressed genes (DEGs) were analyzed and crucial signaling pathways were identified across cell types and between the macula and periphery. The intercellular signaling transduction among cell types were inferred by "CellChat" to build cell–cell communication network under normal and AMD conditions, and verified at the transcriptional level. The CD31+ endothelial cells were obtained to evaluate the enrichment of KEGG pathways in atrophic and neovascular AMD, and GSVA was adopted to discover differential metabolic signals in each AMD type. Thirteen major cell types were identified in the integrated scRNA-seq data. Although no disease-specific cell type or differential cell proportion was found, DEGs and enriched pathways were shown in cell-type- and position-dependent manners. Severe impairment of endothelial cell-mediated cell interactions was found in the signaling transduction network of the macula, and compromised cell interactions were observed in the periphery. Furthermore, distinct signaling pathways and metabolic states were uncovered in atrophic and neovascular AMD. Striking reduction in energy metabolism, lipid metabolism, and oxidative stress was indicated in the atrophic AMD. Conclusively, we discover aberrant signals and metabolic pathways in AMD samples, providing insight into mechanisms and potential therapeutic targets for the AMD treatment.
DOI: 10.6084/m9.figshare.27013139
title: Longitudinal Analysis of Tear Cytokine Ratios in Association with Dry Eye Signs and Symptoms in the Dry Eye Assessment and Management (DREAM) Study

description: To extend cross-sectional data on cytokine ratios (CRs) in dry eye disease (DED) signs by investigating longitudinal change in pro- to anti-inflammatory CRs and associations with change in DED signs and symptoms. Secondary analysis of fifty-four subjects [mean age 57.3 (SD 13.2) years, 85.2% female; 68.5% white] with ≥ 4 uL pooled tear volumes at months 0, 6, and 12. Pro-inflammatory (IL-1b, IL-6, IL-8, IL-17A, IFN-g, and TNF-a) to anti-inflammatory (IL-6, IL-10) cytokine ratios (CR) were calculated. DED signs (corneal and conjunctival staining scores, tear break-up time, Schirmer test, Meibomian gland plugging, tear osmolarity, composite sign severity score) and symptoms [Ocular Surface Disease Index (OSDI)] were measured. Changes over time in DED signs, symptoms, and CRs were evaluated using longitudinal models. Correlations between changes in CR and changes in DED signs and symptoms were evaluated using Spearman correlation coefficients (rho). DED signs which improved over time (<i>p</i> &lt; 0.001) included corneal and conjunctival staining score, tear break-up time, tear osmolarity, and composite sign severity score. Using IL-10 as anti-inflammatory, changes in corneal and conjunctival staining and composite severity score significantly correlated with changes in pro- to anti-inflammatory CRs from month 0 to 6 (|rho|: 0.29-0.45, <i>p</i>: 0.003-0.04) but not between month 0 to 12 (|rho|: 0.01 to 0.24, all <i>p</i> &gt; 0.08). DED symptoms decreased across one year (<i>p</i> &lt; = 0.001) for all OSDI measures; these changes did not correlate with changes in CRs (|rho|: 0.00 to 0.29, all <i>p</i> &gt; 0.04). Improvement in some DED signs across one year correlated weakly with decreases in pro- to anti-inflammatory CRs, in alignment with the understanding of DED as inflammatory. CRs may provide greater insight than absolute tear cytokine concentrations as possible DED biomarkers. Additional studies that provide standardized clinical information and tear collection and analysis are needed to validate CRs in DED.
DOI: 10.15468/dl.6sdbqm
title: Occurrence Download

description: A dataset containing 38942 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Apricaphanius iberus (Valenciennes, 1846), Apricaphanius baeticus (Doadrio, Carmona & Fernández-Delgado, 2002), Gambusia holbrooki Girard, 1859)",
 "OccurrenceStatus is one of (Present)",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 {
 "not" : {
 "BasisOfRecord" : [
 "is one of (Fossil)"
 ]
 }
 },
 "Year is greater than or equal to 1970"
 ]
}

 The dataset includes 38942 records from 165 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0001743-250127130748423/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.21335/nmdc-308042590
title: Forty years of Atlantic cod tag-recapture data from Norway

description: The IMR tag-recapture dataset comprises a total of 50 304 recaptures from the releases of 175 200 tagged cod along the Norwegian coast and in the Barents Sea during the period 1946-1991
DOI: 10.15468/dl.u5mgs3
title: Occurrence Download

description: A dataset containing 1 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Priacanthus japonicus Cuvier, 1829",
 "Geometry POLYGON((170 20, 170 50, 120 50, 120 20, 170 20))",
 "HasCoordinate is true"
 ]
}

 The dataset includes 1 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0001744-250127130748423/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.58132/a0qseq
title: Byzantine amphoras from Apsaros

description: Excavations in Apsaros are conducted by the Gonio-Apsaros Polish-Georgian Expedition, with the Polish part being directed by Prof. R. Karasiewicz-Szczypiorski from the Polish Centre of Mediterranean Archaeology, University of Warsaw.Since 2022 the pottery is analysed within the frame of the project "REM: Roman Military Economy".Data from field seasons 2018-2020 (Polish&Georgian excavations combined).Methodology: macroscopic analysesColumns:Number - Site name and context; GA - Gonio-Apsaros; numbers: numbers of archaeological contexts and layers.Fragment - Abbreviations: R-rims, B-bases, H-handles, N-neck, RNH/RHN - rim+neck+handle (upper vessel part)LHA - a group of amphoras with large handlesType - Ch1: we do not know which type exactly, we just know it is Colchian; Ch1D: Colchian amphora during Byzantine period; Ch1B: Hellenistic and early Roman Colchian amphora; Ch1C: Colchian amphora during the Roman period (1st and 2nd c. CE), larger variantColumn D - 1B: the so called Sinopean fabric (described in a publication); 1A: the so called Colchian fabric (described in a publication)Munsel - Munsell Soil Color Charts https://munsell.com/color-products/color-communications-products/environmental-color-communication/munsell-soil-color-charts/Origin --&gt; place of provenance of amphorasAll other abbreviations are explained in the publication associated with the data. They are clear even without a publication to archaeologists and ceramologists.
DOI: 10.15468/dl.8xq78b
title: Occurrence Download

description: A dataset containing 115 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Heteropriacanthus cruentatus (Lacepède, 1801)",
 "Geometry POLYGON((170 20, 170 50, 120 50, 120 20, 170 20))",
 "HasCoordinate is true"
 ]
}

 The dataset includes 115 records from 24 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0001746-250127130748423/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.tqq92c
title: Occurrence Download

description: A dataset containing 1400 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Geometry POLYGON((-15.01142 27.43177,43.93096 27.43177,43.93096 67.9685,-15.01142 67.9685,-15.01142 27.43177))",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "TaxonKey is Pistacia vera L."
 ]
}

 The dataset includes 1400 records from 41 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0001747-250127130748423/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.tbyuyr
title: Occurrence Download

description: A dataset containing 488 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Physiculus japonicus Hilgendorf, 1879",
 "Geometry POLYGON((170 20, 170 50, 120 50, 120 20, 170 20))",
 "HasCoordinate is true"
 ]
}

 The dataset includes 488 records from 31 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0001748-250127130748423/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.2xxry4
title: Occurrence Download

description: A dataset containing 7533 species occurrences available in GBIF matching the query:
{
 "and" : [
 "License is one of (CC0 1.0, CC-BY 4.0)",
 "OccurrenceStatus is Present",
 "TaxonKey is Sarpa salpa (Linnaeus, 1758)"
 ]
}

 The dataset includes 7533 records from 95 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0001749-250127130748423/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.mrkydn
title: Occurrence Download

description: A dataset containing 40 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Physiculus maximowiczi (Herzenstein, 1896)",
 "Geometry POLYGON((170 20, 170 50, 120 50, 120 20, 170 20))",
 "HasCoordinate is true"
 ]
}

 The dataset includes 40 records from 7 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0001750-250127130748423/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.34740/kaggle/dsv/10600730
title: World Weather Repository ( Daily Updating )
DOI: 10.15468/dl.xfgsbv
title: Occurrence Download

description: A dataset containing 1 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Lotella maximowiczi Herzenstein, 1896",
 "Geometry POLYGON((170 20, 170 50, 120 50, 120 20, 170 20))",
 "HasCoordinate is true"
 ]
}

 The dataset includes 1 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0001751-250127130748423/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.6dgjrf
title: Occurrence Download

description: A dataset containing 9034304 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Alectoris rufa (Linnaeus, 1758), Anas acuta Linnaeus, 1758, Anas crecca Linnaeus, 1758, Anas platyrhynchos Linnaeus, 1758, Ardea cinerea Linnaeus, 1758, Arenaria interpres (Linnaeus, 1758), Asio otus (Linnaeus, 1758), Aythya fuligula (Linnaeus, 1758), Buteo buteo (Linnaeus, 1758), Calidris alba (Pallas, 1764), Carduelis carduelis (Linnaeus, 1758), Charadrius alexandrinus Linnaeus, 1758, Carduelis chloris (Linnaeus, 1758), Columba livia J.F.Gmelin, 1789, Columba palumbus azorica Hartert, 1905, Coturnix coturnix (Linnaeus, 1758), Egretta garzetta (Linnaeus, 1766), Erithacus rubecula (Linnaeus, 1758), Fringilla coelebs Linnaeus, 1758, Fulica atra Linnaeus, 1758, Gallinago gallinago (Linnaeus, 1758), Gallinula chloropus (Linnaeus, 1758), Limosa limosa (Linnaeus, 1758), Mareca penelope (Linnaeus, 1758), Motacilla cinerea Tunstall, 1771, Passer domesticus (Linnaeus, 1758), Pluvialis squatarola (Linnaeus, 1758), Pyrrhula murina Godman, 1866, Regulus regulus (Linnaeus, 1758), Scolopax rusticola Linnaeus, 1758, Serinus canaria (Linnaeus, 1758), Spatula clypeata (Linnaeus, 1758), Streptopelia decaocto (Frivaldszky, 1838), Sturnus vulgaris Linnaeus, 1758, Sylvia atricapilla (Linnaeus, 1758), Turdus merula Linnaeus, 1758)",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 {
 "not" : {
 "BasisOfRecord" : [
 "is one of (Fossil, Living Specimen, Material citation)"
 ]
 }
 },
 "Year is greater than or equal to 2019",
 "Year is less than or equal to 2024",
 "HasCoordinate is true",
 "Geometry POLYGON ((-31.5 39.5, -24.5 39.5, -24.5 36.5, -31.5 36.5, -31.5 39.5))"
 ]
}

 The dataset includes 9034304 records from 65 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0001745-250127130748423/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.ugc6sd
title: Occurrence Download

description: A dataset containing 23562 species occurrences available in GBIF matching the query:
{
 "DatasetKey" : [
 "is Arctic Species Trend Index (ASTI) : Marine"
 ]
}

 The dataset includes 23562 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0001752-250127130748423/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.