cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.20317263
title: Supplementary Material for: Sex Hormones in Males and Females with Active Central Serous Chorioretinopathy

description: Purpose: To assess the role of sex hormones in male and female patients with central serous chorioretinopathy (CSC), a disease with a pronounced male predilection. Methods: A total of 206 chronic CSC patients (183 males, 23 females) and 59 healthy controls (29 males, 30 females) were enrolled. Serum testosterone, estradiol, albumin, and sex hormone-binding globulin levels were determined using immunoassays. The free fraction of testosterone and the free testosterone/estradiol-ratio were calculated. Results: No differences in the levels of total testosterone and estradiol were observed between CSC patients and healthy controls. Albumin levels were found to be lower in male CSC patients compared to controls (controls 47.8 g/L, patients 46.0 g/L, adj. p = 0.006). Only in females with CSC, sex hormone-binding globulin levels were found to be lower (controls 94.2 nmol/L, patients 50.4 nmol/L, adj. p = 0.001), together with a higher free testosterone/estradiol-ratio (controls 0.06, patients 0.18, adj. p = 0.018). Conclusions: In this study, we did not find evidence for a disturbance in sex hormone levels in males with CSC. The lower levels of sex hormone-binding globulin in females with CSC, leading to a disturbed free testosterone/estradiol-ratio, warrants further investigation into the role of androgens in females with CSC.
DOI: 10.6084/m9.figshare.20317263.v1
title: Supplementary Material for: Sex Hormones in Males and Females with Active Central Serous Chorioretinopathy

description: Purpose: To assess the role of sex hormones in male and female patients with central serous chorioretinopathy (CSC), a disease with a pronounced male predilection. Methods: A total of 206 chronic CSC patients (183 males, 23 females) and 59 healthy controls (29 males, 30 females) were enrolled. Serum testosterone, estradiol, albumin, and sex hormone-binding globulin levels were determined using immunoassays. The free fraction of testosterone and the free testosterone/estradiol-ratio were calculated. Results: No differences in the levels of total testosterone and estradiol were observed between CSC patients and healthy controls. Albumin levels were found to be lower in male CSC patients compared to controls (controls 47.8 g/L, patients 46.0 g/L, adj. p = 0.006). Only in females with CSC, sex hormone-binding globulin levels were found to be lower (controls 94.2 nmol/L, patients 50.4 nmol/L, adj. p = 0.001), together with a higher free testosterone/estradiol-ratio (controls 0.06, patients 0.18, adj. p = 0.018). Conclusions: In this study, we did not find evidence for a disturbance in sex hormone levels in males with CSC. The lower levels of sex hormone-binding globulin in females with CSC, leading to a disturbed free testosterone/estradiol-ratio, warrants further investigation into the role of androgens in females with CSC.
DOI: 10.6084/m9.figshare.21677213
title: Driving tourist to be green 7_DATA.xlsx

description: Food is an essential component of the tourism experience, yet its production is said to significantly influences global warming and climate change. One strategy to minimise global warming is to offer tourists an environmentally friendly diet option such as plant-based foods (PBF). This research data observes the formation of young tourists' attitudes and behavioural intentions on their experiences of PBF consumption by incorporating value consumption, concern for the environment, and perceived costs as the influencing factors. Data was collected from 267 young tourists in Indonesia.
DOI: 10.5281/zenodo.7413790
title: AIS data prepared by Statsat AS for January 2020

description: AIS data prepared and provided by Statsat AS (Norway) in the framework of the T-SAR project (<em>IKTPLUSS programme on reducing digital vulnerabilities, </em><strong>10 MNOK from the Research Council of Norway, Norway</strong>). The dataset contains AIS data (satellite + other) on a global coverage for 2020. There is one zip file and its name is the month (01 for January to 12 for December) ending with '.zip' and the zip file contains zipped Comma Separated Values (CSV) files; one per day. The CSV zipped files are named with the following convention: ais_YYYYMMDD.zip where YYYY is the year (here 2020), MM the month (01 to 12) and DD the day (01 to 31 depending on the month). For instance, ais_20200101.zip contains one single CSV file called ais_20200101.csv that corresponds to the 1st January 2020. The csv files have one header line: mmsi;lon;lat;date_time_utc;sog;cog;true_heading;nav_status;rot;message_nr;source where: <strong>mmsi</strong> integer MMSI number of the vessel (AIS identifier). All records belonging to the same vessel will have the same identifier. <strong>lon</strong> float Geographical longitude (WGS84) between -180 to 180 <strong>lat</strong> float Geographical latitude (WGS84) between -90 to 90 <strong>date_time_utc</strong> datetime Date and Time (in UTC) when position was recorded by AIS. It is represented as: YYYY-MM-DD HH:MM:SS (for instance 2020-01-01 00:00:00). <strong>sog</strong> float Speed over ground (knots) <strong>cog</strong> float Course over ground (degrees) <strong>true_heading</strong> integer Heading (degrees) of the vessel's hull. A value of 511 indicates there is no heading data. <strong>nav_status</strong> integer Navigation status according to <strong>AIS Specification</strong> <strong>rot</strong> integer rate of turn <strong>message_nr</strong> integer message number <strong>source</strong> integer source is the source of AIS data ('g' for ground or 's' for satellite). One row in the CSV file corresponds to one message.
description: This dataset is not public and has been provided by Statsat AS (Norway). It has been used for developing new machine learning algorithms for detecting Intentional AIS Shutdown in Open Sea Maritime Surveillance in the framework of the T-SAR project (IKTPLUSS programme on reducing digital vulnerabilities, 10 MNOK from the Research Council of Norway, Norway) led by Simula Research Laboratory (Oslo, Norway).
DOI: 10.5281/zenodo.7413789
title: AIS data prepared by Statsat AS for January 2020

description: AIS data prepared and provided by Statsat AS (Norway) in the framework of the T-SAR project (<em>IKTPLUSS programme on reducing digital vulnerabilities, </em><strong>10 MNOK from the Research Council of Norway, Norway</strong>). The dataset contains AIS data (satellite + other) on a global coverage for 2020. There is one zip file and its name is the month (01 for January to 12 for December) ending with '.zip' and the zip file contains zipped Comma Separated Values (CSV) files; one per day. The CSV zipped files are named with the following convention: ais_YYYYMMDD.zip where YYYY is the year (here 2020), MM the month (01 to 12) and DD the day (01 to 31 depending on the month). For instance, ais_20200101.zip contains one single CSV file called ais_20200101.csv that corresponds to the 1st January 2020. The csv files have one header line: mmsi;lon;lat;date_time_utc;sog;cog;true_heading;nav_status;rot;message_nr;source where: <strong>mmsi</strong> integer MMSI number of the vessel (AIS identifier). All records belonging to the same vessel will have the same identifier. <strong>lon</strong> float Geographical longitude (WGS84) between -180 to 180 <strong>lat</strong> float Geographical latitude (WGS84) between -90 to 90 <strong>date_time_utc</strong> datetime Date and Time (in UTC) when position was recorded by AIS. It is represented as: YYYY-MM-DD HH:MM:SS (for instance 2020-01-01 00:00:00). <strong>sog</strong> float Speed over ground (knots) <strong>cog</strong> float Course over ground (degrees) <strong>true_heading</strong> integer Heading (degrees) of the vessel's hull. A value of 511 indicates there is no heading data. <strong>nav_status</strong> integer Navigation status according to <strong>AIS Specification</strong> <strong>rot</strong> integer rate of turn <strong>message_nr</strong> integer message number <strong>source</strong> integer source is the source of AIS data ('g' for ground or 's' for satellite). One row in the CSV file corresponds to one message.
description: This dataset is not public and has been provided by Statsat AS (Norway). It has been used for developing new machine learning algorithms for detecting Intentional AIS Shutdown in Open Sea Maritime Surveillance in the framework of the T-SAR project (IKTPLUSS programme on reducing digital vulnerabilities, 10 MNOK from the Research Council of Norway, Norway) led by Simula Research Laboratory (Oslo, Norway).
DOI: 10.25502/j69s-d524/d
title: Endosymbiont diversity in the scale insect Stictococcus vayssierei, the African root and tuber scale

description: The general objective of the project was to enhance our knowledge on the bio-ecology of S. vayssierei, a pest of root and tuber crops in the Congo Basin, for an ultimate goal of minimizing ARTS infestation and in turn increasing yields and productivity of cassava and other root and tuber crops in Central Africa. In this study, we characterized the diversity and prevalence of bacterial endosymbionts associated with the S. vayssierei species complex as these endosymbionts may influence the pest status of the scale insect, and may provide an alternative target for pest control.
DOI: 10.6084/m9.figshare.21534096
title: Data of affine arithmetic-based optimal power-gas flow

description: Data of IEGS with IEEE 5-bus power system and 6-node gas system is used for case studies of paper entitled"2023 Convex Optimization Method for Affine Arithmetic-based Optimal Power-Gas Flow under Wind Power Uncertainty-Xianghao Zheng".
DOI: 10.6084/m9.figshare.21534096.v2
title: Data of affine arithmetic-based optimal power-gas flow

description: Data of IEGS with IEEE 5-bus power system and 6-node gas system is used for case studies of paper entitled"2023 Convex Optimization Method for Affine Arithmetic-based Optimal Power-Gas Flow under Wind Power Uncertainty-Xianghao Zheng".
DOI: 10.6084/m9.figshare.21534096.v1
title: Data of AA OPGF

description: Data of IEGS with IEEE 5-bus power system and 6-node gas system is used for case studies of paper entitled " 2023 Convex Optimization Method for Affine Arithmetic-based Optimal Power-Gas Flow under Wind Power Uncertainty-Xianghao Zheng".
DOI: 10.24380/8fck-9w87
title:  CAMS global greenhouse gas reanalysis (EGG4)
DOI: 10.6084/m9.figshare.19620783.v1
title: Rhythmic coordination of hippocampal-prefrontal ensembles for odor-place associative memory and decision making

description: This is a neural and behavioral datset from 26 sessions from 6 rats performing an odor guided memory task. The neural data are from CA1, Prelimbic Cortex, and Olfactory Bulb.
DOI: 10.6084/m9.figshare.20079107
title: Supplementary Material for: An in vitro Comparative Assessment of Single-Use Flexible Ureteroscopes Using a Standardized Ureteroscopy Training Model

description: <b><i>Introduction:</i></b> Perceived benefits like decreased contamination rates and reduced postoperative incidence of complications after urolithiasis surgery have led to increased adoption of single-use flexible ureteroscopes (su-fURS). Using a validated, standardized simulator model with enhanced “fluoroscopic” capabilities, we performed an in vitro comparative assessment of four commercially available models of su-fURS. Both objective and subjective parameters were assessed in this study. <b><i>Methods:</i></b> Two standardized tasks, (1) exploration of the model’s kidney collecting system and (2) repositioning of a stone fragment from the upper renal to lower renal pole were assigned to participants, who performed these tasks on all four scopes. Four models of su-fURS (Boston LithoVue, PUSEN PU3033A, REDPINE, INNOVEX EU-Scope<sup>TM</sup>) were assessed, with task timings as end-points for objective analysis. Cumulative “fluoroscopic” time was also recorded as a novel feature of our enhanced model. Post-task questionnaires evaluating specific components of the scopes were distributed to document subjective ratings. <b><i>Results:</i></b> Both subjective and objective performances (except stone repositioning time) across all four su-fURS demonstrated significant differences. However, objective performance (task timings) did not reflect subjective scope ratings by the participants (<i>R</i><sub>s</sub> &lt; 0.6). Upon Kruskal-Wallis <i>H</i> test with post hoc analyses, REDPINE and INNOVEX EU-Scope<sup>TM</sup> were the preferred su-fURS as rated by the participants, with overall scope scores of 9.00/10 and 9.57/10. <b><i>Conclusions:</i></b> Using a standardized in vitro simulation model with enhanced fluoroscopic capabilities, we demonstrated both objective and subjective differences between models of su-fURS. However, variations in perception of scope features (visibility, image quality, deflection, maneuverability, ease of stone retrieval) did not translate into actual technical performance. Eventually, the optimal choice of su-fURS fundamentally lies in individual surgeon preference, as well as cost-related factors.
DOI: 10.6084/m9.figshare.20101649
title: Supplementary Material for: 7-Methylxanthine Influences the Behavior of ADORA2A-DRD2 Heterodimers in Human Retinal Pigment Epithelial Cells

description: Introduction: The goal of this study was to investigate the presence of ADORA2A-DRD2 heterodimers in human RPE cells; determine if 7-methylxanthine (7-MX), a non-selective adenosine receptor antagonist which was used to control myopia progression can influence the behavior of retinal pigment epithelial (RPE) cells through the ADORA2A-DRD2 receptor pathway, and assess the changes in the expression of signaling molecules during cellular signal transduction. Methods: Human RPE cells were cultured in vitro in the presence or absence of 7-MX. Cell proliferation was evaluated with the CCK-8 assay. Apoptosis and necrosis rates were determined by annexin V–FITC/propidium iodide (PI) staining and flow cytometry. Immunofluorescence and coimmunoprecipitation were used to examine the protein expression and colocalization of ADORA2A and DRD2 in RPE cells. ADORA2A and DRD2 were knocked down with small interfering RNAs (siRNAs). Changes in the protein expression of ERK1/2 and phospho-ERK1/2 (pERK 1/2), which are signaling molecules downstream of dopamine (DA) receptors, were evaluated by western blot analysis. Results: Immunofluorescence and coimmunoprecipitation showed that ADORA2A and DRD2 were colocalized in RPE cells. The expression of ADORA2A in RPE cells was inhibited by treatment with 50 µmol/l 7-MX for 48 h, and the expression of DRD2, ERK1/2, and pERK1/2 was increased after treatment with 50 µmol/l 7-MX for 48 h. After siRNA-mediated knockdown of DRD2 in RPE cells and further treatment with 50 µmol/l 7-MX for 48 h, the expression of DRD2 was nearly restored to the level observed in the native control. At the experimental concentrations, 7-MX and siRNAs did not affect the proliferation or apoptosis of human RPE cells. Conclusions: ADORA2A and DRD2 heterodimers were present in RPE cells. 7-MX may affect the behaviors of RPE cells through the ADORA2A-DRD2 receptor pathway. 7-MX is an inhibitor of ADORA2A receptors that can prevent inhibition of the D2 receptor pathway and increase D2 receptor pathway activity. This phenomenon may explain the mechanism of action through which 7-MX can control myopia progression.
DOI: 10.6084/m9.figshare.20260551
title: Supplementary Material for: Mechanism of myopic defocus or atropine for myopia control: different or similar ways?

description: Abstract Introduction: Myopia is usually caused by excessive elongation of the eye during development. This condition is common worldwide. In clinical practice, the progression of myopia is commonly controlled through optical or drug measures, but the specific mechanisms underlying these two treatments remain unclear. To verify whether the effects of these two treatments on posterior-pole tissues are similar or different, we studied a set of common transcriptional changes in chicken models. Methods: Chicks were divided into four groups, and they were given the intervention measures of plus-lens induction, minus-lens induction, minus-lens induction with atropine injection, and minus-lens induction with saline injection. Then, the genetic changes in each tissue at the posterior pole were detected, and the results of different genes were compared. A semiquantitative real-time polymerase chain reaction (RT-PCR) method was used to further study the visually induced changes in the transcription of potential candidate genes. Results: Based on RNA-sequencing (RNA-seq) analysis of the transcriptome, we identified variations between the differentially expressed transcripts (DETs) in three tissues from the two treatment groups. Through Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses, eukaryotic protein translation elongation factor 1α2 (EEF1A2) was enriched in the ‘leishmaniasis’ pathway in the choroid and showed increased expression in both the plus-lens induction and injection atropine groups. The expression levels of selected genes verified by qPCR were concordant with the RNA-seq data. Conclusions: Overlapping differentially expressed mRNAs of only one-tenth could suggest a different mechanism of myopic defocus and intravitreal injection of atropine controlling myopia. EEF1A2 might play an important role in the choroid during the treatment of myopia.
DOI: 10.6084/m9.figshare.21550659
title: Supplementary Material for: The Mechanism of Delayed Ischemic Preconditioning in Alleviating Acute Ischemia/Reperfusion Renal Injury through Treg Mediated by Immature CD11c<sup>+</sup> Dendritic Cells

description: <b><i>Introduction:</i></b> Renal ischemia-reperfusion injury (IRI) is one of the major causes of acute kidney injury, and its mechanism is complex involving multiple factors, while delayed ischemic preconditioning (DIPC) has a protective effect on the above process. In our previous study, we found that DIPC can exert its protection on renal IRI by inhibiting the maturation of dendritic cells (DCs), but the mechanism has not been clarified. This study aimed to investigate the protective mechanism of DIPC on renal IRI in mice through Treg mediated by immature DCs (imDCs). <b><i>Methods:</i></b> The IRI mice model, DIPC treatment, and conditional CD11c<sup>+</sup> DCs (CD11c-DTR) knockout mice were used to perform our study. The maturation and differentiation of DCs and Treg cells in the kidney and spleen were analyzed by flow cytometry. HE staining was used to evaluate the pathology of the kidney tissue. The level of creatinine (Cr), oxidative stress factors (SOD, MDA), and inflammatory factors (TNF-α, IL-10, IL-4) were also measured. Then, imDCs were co-cultured with HK-2 cells, and apoptosis was analyzed with flow cytometry and PI-Hoechst 33,342 fluorescence staining to assess the apoptosis rate of HK-2 cells under hypoxic-reoxygenated (H/R) conditions. <b><i>Results:</i></b> DIPC could decrease renal Cr levels, alleviate pathological renal damage, and reduce oxidative stress and inflammation caused by IRI. Moreover, DIPC could decrease the number of mature DCs (mDCs) and increase Treg lymphocyte infiltration in the kidney tissue, while the reduction of DCs reversed this process. In addition, our in vitro experiment found that in the H/R model, the apoptosis of HK-2 cells decreased which were co-cultured with imDCs. <b><i>Conclusion:</i></b> DIPC can regulate the differentiation of DCs into imDCs, thus affecting the differentiation level and distribution of Treg cells to exert its protective effect on renal IRI.
DOI: 10.6084/m9.figshare.21688565
title: Supplementary Material for: Cardiovascular Diseases, Medications, and ALS: A Population-Based Case-Control Study

description: <b><i>Introduction:</i></b> We investigated the associations between antecedent all-cause CVD diagnoses, cause-specific CVD diagnosis, and CVD medication prescriptions with the risk of developing amyotrophic lateral sclerosis (ALS). <b><i>Materials and Methods:</i></b> We conducted a population-based case-control study of U.S. Medicare enrollees from 2006 to 2013. The final sample included 3,714 incident ALS cases and 18,570 controls (matched on age, sex, enrollment length, and county). Information was collected from Medicare Parts A, B, and D administrative claims data on hypertension, ischemic heart disease, heart failure, acute myocardial infarction, atrial fibrillation, prescriptions of angiotensin-converting enzyme inhibitors, angiotensin II receptors blockers, calcium channel blockers, beta blockers, and antiarrhythmics. Associations were evaluated using conditional logistic regression adjusting for age, sex, race/ethnicity, geographical location, alcohol and tobacco use, and socioeconomic status. <b><i>Results:</i></b> The odds ratio (OR) for having one or more ICD-9 codes for any cardiovascular disease diagnosis at least 24 months prior to the date of ALS diagnosis was 0.85 (95% conﬁdence interval [CI]: 0.78–0.92). Cardiovascular conditions that were inversely associated with ALS included heart failure (OR = 0.79; 95% CI 0.70–0.89), atrial fibrillation (OR = 0.81; 95% CI 0.77–0.92), and hypertension (OR = 0.91; 95% CI 0.84–0.98). Exposures to several classes of cardiovascular medications were inversely associated with ALS risk even after adjusting for confounding by indication, including ACE inhibitors (OR = 0.84, 95% CI 0.77–0.91), calcium channel blockers (OR = 0.64, 95% CI 0.59–0.70), and beta blockers (OR = 0.76, 95% CI 0.71–0.83). <b><i>Discussion/Conclusion:</i></b> These findings merit additional research, including animal studies and pilot clinical trials, to further evaluate and evidence the effects of ACEIs, CCBs, and BBs on the risk of developing and clinical expression of ALS.
DOI: 10.6084/m9.figshare.21694682
title: Supplementary Material for: The Challenging Management of Acute Thrombotic Microangiopathy in Pregnancy

description: Thrombotic microangiopathy is characterized by microangiopathic hemolytic anemia, thrombocytopenia, and end-organ injury. Pregnancy-associated thrombotic microangiopathy is a severe disorder with a high risk of maternal mortality and poor fetal outcomes. Preeclampsia/eclampsia and hemolysis, elevated liver enzymes, and low platelets syndrome are the most common causes, and hemolytic uremic syndrome or thrombotic thrombocytopenic purpura are rare causes. Due to overlapping clinical findings, the differential diagnosis is challenging and should be managed by a multidisciplinary team. We present a case of a 38-year-old woman at 40 weeks of second gestation, admitted with thrombotic microangiopathy being the final diagnosis not immediately clear.