cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.6293057
title: Metabolic reprogramming enables hepatocarcinoma cells to efficiently adapt and survive to a nutrient-restricted microenvironment

description: Hepatocellular carcinoma (HCC) is a metabolically heterogeneous cancer and the use of glucose by HCC cells could impact their tumorigenicity. Dt81Hepa1-6 cells display enhanced tumorigenicity compared to parental Hepa1-6 cells. This increased tumorigenicity could be explained by a metabolic adaptation to more restrictive microenvironments. When cultured at high glucose concentrations, Dt81Hepa1-6 displayed an increased ability to uptake glucose (<i>P</i>&lt;0.001), increased expression of 9 glycolytic genes, greater GTP and ATP (<i>P</i>&lt;0.001), increased expression of 7 fatty acid synthesis-related genes (<i>P</i>&lt;0.01) and higher levels of Acetyl-CoA, Citrate and Malonyl-CoA (<i>P</i>&lt;0.05). Under glucose-restricted conditions, Dt81Hepa1-6 used their stored fatty acids with increased expression of fatty acid oxidation-related genes (<i>P</i>&lt;0.01), decreased triglyceride content (<i>P</i>&lt;0.05) and higher levels of GTP and ATP (<i>P</i>&lt;0.01) leading to improved proliferation (<i>P</i>&lt;0.05). Inhibition of lactate dehydrogenase and aerobic glycolysis with sodium oxamate led to decreased expression of glycolytic genes, reduced lactate, GTP and ATP levels (<i>P</i>&lt;0.01), increased cell doubling time (<i>P</i>&lt;0.001) and reduced fatty acid synthesis. When combined with cisplatin, this inhibition led to lower cell viability and proliferation (<i>P</i>&lt;0.05). This metabolic-induced tumorigenicity was also reflected in human Huh7 cells by a higher glucose uptake and proliferative capacity compared to HepG2 cells (<i>P</i>&lt;0.05). In HCC patients, increased tumoral expression of <i>Glut-1</i>, <i>Hexokinase II</i> and <i>Lactate dehydrogenase</i> correlated with poor survival (<i>P</i> = 2.47E<sup>−5</sup>, <i>P</i> = 0.016 and <i>P</i> = 6.58E<sup>−5</sup>). In conclusion, HCC tumorigenicity can stem from a metabolic plasticity allowing them to thrive in a broader range of glucose concentrations. In HCC, combining glycolytic inhibitors with conventional chemotherapy could lead to improved treatment efficacy.
DOI: 10.6084/m9.figshare.6293057.v1
title: Metabolic reprogramming enables hepatocarcinoma cells to efficiently adapt and survive to a nutrient-restricted microenvironment

description: Hepatocellular carcinoma (HCC) is a metabolically heterogeneous cancer and the use of glucose by HCC cells could impact their tumorigenicity. Dt81Hepa1-6 cells display enhanced tumorigenicity compared to parental Hepa1-6 cells. This increased tumorigenicity could be explained by a metabolic adaptation to more restrictive microenvironments. When cultured at high glucose concentrations, Dt81Hepa1-6 displayed an increased ability to uptake glucose (<i>P</i>&lt;0.001), increased expression of 9 glycolytic genes, greater GTP and ATP (<i>P</i>&lt;0.001), increased expression of 7 fatty acid synthesis-related genes (<i>P</i>&lt;0.01) and higher levels of Acetyl-CoA, Citrate and Malonyl-CoA (<i>P</i>&lt;0.05). Under glucose-restricted conditions, Dt81Hepa1-6 used their stored fatty acids with increased expression of fatty acid oxidation-related genes (<i>P</i>&lt;0.01), decreased triglyceride content (<i>P</i>&lt;0.05) and higher levels of GTP and ATP (<i>P</i>&lt;0.01) leading to improved proliferation (<i>P</i>&lt;0.05). Inhibition of lactate dehydrogenase and aerobic glycolysis with sodium oxamate led to decreased expression of glycolytic genes, reduced lactate, GTP and ATP levels (<i>P</i>&lt;0.01), increased cell doubling time (<i>P</i>&lt;0.001) and reduced fatty acid synthesis. When combined with cisplatin, this inhibition led to lower cell viability and proliferation (<i>P</i>&lt;0.05). This metabolic-induced tumorigenicity was also reflected in human Huh7 cells by a higher glucose uptake and proliferative capacity compared to HepG2 cells (<i>P</i>&lt;0.05). In HCC patients, increased tumoral expression of <i>Glut-1</i>, <i>Hexokinase II</i> and <i>Lactate dehydrogenase</i> correlated with poor survival (<i>P</i> = 2.47E<sup>−5</sup>, <i>P</i> = 0.016 and <i>P</i> = 6.58E<sup>−5</sup>). In conclusion, HCC tumorigenicity can stem from a metabolic plasticity allowing them to thrive in a broader range of glucose concentrations. In HCC, combining glycolytic inhibitors with conventional chemotherapy could lead to improved treatment efficacy.
DOI: 10.6084/m9.figshare.6293012
title: Genetic testing and Colonoscopy screening costs in Lynch Syndrome

description: Cost information of two screening strategies for colorectal cancer in Lynch Syndrome: Colonoscopy only compared to genetic testing + colonoscopy, South Africa
DOI: 10.6084/m9.figshare.6293012.v1
title: Genetic testing and Colonoscopy screening costs in Lynch Syndrome

description: Cost information of two screening strategies for colorectal cancer in Lynch Syndrome: Colonoscopy only compared to genetic testing + colonoscopy, South Africa
DOI: 10.6084/m9.figshare.6292982
title: Umeclidinium/Vilanterol versus Tiotropium/Olodaterol in Maintenance-Naïve Patients with Moderate Symptomatic Chronic Obstructive Pulmonary Disease: A Post Hoc Analysis

description: <b>Article full text</b> <br> The full text of this article can be found here<b>. </b>https://link.springer.com/article/10.1007/s41030-018-0057-7 <br> <b>Provide enhanced content for this article</b> <br> If you are an author of this publication and would like to provide additional enhanced content for your article then please contact <b>adisrapidplus@springer.com</b>. <br> The journal offers a range of additional features designed to increase visibility and readership. All features will be thoroughly peer reviewed to ensure the content is of the highest scientific standard and all features are marked as ‘peer reviewed’ to ensure readers are aware that the content has been reviewed to the same level as the articles they are being presented alongside. Moreover, all sponsorship and disclosure information is included to provide complete transparency and adherence to good publication practices. This ensures that however the content is reached the reader has a full understanding of its origin. No fees are charged for hosting additional open access content. <br> Other enhanced features include, but are not limited to: <br> • Videos and animations<br> • Audio abstracts • Audio slides<br>
DOI: 10.6084/m9.figshare.6292982.v2
title: Umeclidinium/Vilanterol versus Tiotropium/Olodaterol in Maintenance-Naïve Patients with Moderate Symptomatic Chronic Obstructive Pulmonary Disease: A Post Hoc Analysis

description: <b>Article full text</b> <br> The full text of this article can be found here<b>. </b>https://link.springer.com/article/10.1007/s41030-018-0057-7 <br> <b>Provide enhanced content for this article</b> <br> If you are an author of this publication and would like to provide additional enhanced content for your article then please contact <b>adisrapidplus@springer.com</b>. <br> The journal offers a range of additional features designed to increase visibility and readership. All features will be thoroughly peer reviewed to ensure the content is of the highest scientific standard and all features are marked as ‘peer reviewed’ to ensure readers are aware that the content has been reviewed to the same level as the articles they are being presented alongside. Moreover, all sponsorship and disclosure information is included to provide complete transparency and adherence to good publication practices. This ensures that however the content is reached the reader has a full understanding of its origin. No fees are charged for hosting additional open access content. <br> Other enhanced features include, but are not limited to: <br> • Videos and animations<br> • Audio abstracts • Audio slides<br>
DOI: 10.6084/m9.figshare.6292901
title: Complete experimental data

description: data from marble burying and open field testsdata from immunofluorescence of PL-PFCdata from ELISA and western blotting
DOI: 10.6084/m9.figshare.6292901.v1
title: in vivo data

description: data from marble burying and open field testsdata from immunofluorescence of PL-PFC
DOI: 10.6084/m9.figshare.6292901.v2
title: all datasets

description: data from marble burying and open field testsdata from immunofluorescence of PL-PFCdata from ELISA and western blotting
DOI: 10.6084/m9.figshare.6292901.v3
title: Complete experimental raw data

description: data from marble burying and open field testsdata from immunofluorescence of PL-PFCdata from ELISA and western blotting
DOI: 10.6084/m9.figshare.6292901.v4
title: Complete experimental raw data

description: data from marble burying and open field testsdata from immunofluorescence of PL-PFCdata from ELISA and western blotting
DOI: 10.6084/m9.figshare.6292901.v5
title: Complete experimental raw data

description: data from marble burying and open field testsdata from immunofluorescence of PL-PFCdata from ELISA and western blotting
DOI: 10.6084/m9.figshare.6292901.v6
title: Complete experimental data

description: data from marble burying and open field testsdata from immunofluorescence of PL-PFCdata from ELISA and western blotting
DOI: 10.6084/m9.figshare.6292901.v7
title: Complete experimental data

description: data from marble burying and open field testsdata from immunofluorescence of PL-PFCdata from ELISA and western blotting
DOI: 10.6084/m9.figshare.6292901.v8
title: Complete experimental data

description: data from marble burying and open field testsdata from immunofluorescence of PL-PFCdata from ELISA and western blotting
DOI: 10.6084/m9.figshare.6292901.v9
title: Complete experimental data

description: data from marble burying and open field testsdata from immunofluorescence of PL-PFCdata from ELISA and western blotting
DOI: 10.6084/m9.figshare.6292901.v10
title: Complete experimental data

description: data from marble burying and open field testsdata from immunofluorescence of PL-PFCdata from ELISA and western blotting
DOI: 10.6084/m9.figshare.6292883
title: in vitro data

description: data from multiple ELISA assays
DOI: 10.6084/m9.figshare.6292340
title: Early Cretaceous granitic rocks from the southern Jiaodong Peninsula, eastern China: implications for lithospheric extension

description: Zircon U–Pb ages, major element and trace element compositions, and Sr, Nd, and Pb isotopic compositions for late Mesozoic granites from the southern Jiaodong Peninsula (eastern China) were determined. Ages for the Wulianshan, Xiaozhushan, and Dazhushan plutons are 119.1–122.3, 114.2, and 108.9 Ma, respectively. Major and trace element characteristics show that these granitic rocks belong to alkaline, A-type granites formed in an extensional setting. Trace element compositions show strong, variable negative anomalies in Ba, K, P and Ti, and positive anomalies in Rb, Th, U, Pb, Ce, Zr, and Hf, which are typical characteristics of A-type granites. Variable Sr and Nd isotopic compositions, <sup>87</sup>Sr/<sup>86</sup>Sr(i) = 0.70540–0.7071 and <i>ε</i>Nd(<i>t</i>) = −14.5 to −20.9. Whole-rock Pb isotopic compositions have the following ranges, (<sup>206</sup>Pb/<sup>204</sup>Pb)<i>t</i> = 15.707–16.561, (<sup>207</sup>Pb/<sup>204</sup>Pb)<i>t</i> = 15.376–16.462, and (<sup>208</sup>Pb/<sup>204</sup>Pb)<i>t</i> = 36.324 to 37.064. Isotopic modelling indicates an origin that lies between mantle tapped by Cenozoic basalts around the Tan-Lu megafault and lower continental crust (LCC), and which can be explained by mixing of 11–18% mantle and 82–89% LCC. Based on new and compiled data, we suggest that the southern Jiaodong Peninsula, as well as the Laoshan area, was in a regional extensional setting of an orogenic belt during 106–126 Ma. The granitic rocks may be the result of late Mesozoic lithospheric thinning and decratonization (i.e. late Mesozoic craton destruction event occurring throughout eastern China).
DOI: 10.6084/m9.figshare.6292340.v2
title: Early Cretaceous granitic rocks from the southern Jiaodong Peninsula, eastern China: implications for lithospheric extension

description: Zircon U–Pb ages, major element and trace element compositions, and Sr, Nd, and Pb isotopic compositions for late Mesozoic granites from the southern Jiaodong Peninsula (eastern China) were determined. Ages for the Wulianshan, Xiaozhushan, and Dazhushan plutons are 119.1–122.3, 114.2, and 108.9 Ma, respectively. Major and trace element characteristics show that these granitic rocks belong to alkaline, A-type granites formed in an extensional setting. Trace element compositions show strong, variable negative anomalies in Ba, K, P and Ti, and positive anomalies in Rb, Th, U, Pb, Ce, Zr, and Hf, which are typical characteristics of A-type granites. Variable Sr and Nd isotopic compositions, <sup>87</sup>Sr/<sup>86</sup>Sr(i) = 0.70540–0.7071 and <i>ε</i>Nd(<i>t</i>) = −14.5 to −20.9. Whole-rock Pb isotopic compositions have the following ranges, (<sup>206</sup>Pb/<sup>204</sup>Pb)<i>t</i> = 15.707–16.561, (<sup>207</sup>Pb/<sup>204</sup>Pb)<i>t</i> = 15.376–16.462, and (<sup>208</sup>Pb/<sup>204</sup>Pb)<i>t</i> = 36.324 to 37.064. Isotopic modelling indicates an origin that lies between mantle tapped by Cenozoic basalts around the Tan-Lu megafault and lower continental crust (LCC), and which can be explained by mixing of 11–18% mantle and 82–89% LCC. Based on new and compiled data, we suggest that the southern Jiaodong Peninsula, as well as the Laoshan area, was in a regional extensional setting of an orogenic belt during 106–126 Ma. The granitic rocks may be the result of late Mesozoic lithospheric thinning and decratonization (i.e. late Mesozoic craton destruction event occurring throughout eastern China).
DOI: 10.6084/m9.figshare.6292340.v1
title: Early cretaceous granitic rocks from the southern Jiaodong Peninsula, eastern China: implications for lithospheric extension

description: Zircon U–Pb ages, major element and trace element compositions, and Sr, Nd, and Pb isotopic compositions for late Mesozoic granites from the southern Jiaodong Peninsula (eastern China) were determined. Ages for the Wulianshan, Xiaozhushan, and Dazhushan plutons are 119.1–122.3, 114.2, and 108.9 Ma, respectively. Major and trace element characteristics show that these granitic rocks belong to alkaline, A-type granites formed in an extensional setting. Trace element compositions show strong, variable negative anomalies in Ba, K, P and Ti, and positive anomalies in Rb, Th, U, Pb, Ce, Zr, and Hf, which are typical characteristics of A-type granites. Variable Sr and Nd isotopic compositions, <sup>87</sup>Sr/<sup>86</sup>Sr(i) = 0.70540–0.7071 and <i>ε</i>Nd(<i>t</i>) = −14.5 to −20.9. Whole-rock Pb isotopic compositions have the following ranges, (<sup>206</sup>Pb/<sup>204</sup>Pb)<i>t</i> = 15.707–16.561, (<sup>207</sup>Pb/<sup>204</sup>Pb)<i>t</i> = 15.376–16.462, and (<sup>208</sup>Pb/<sup>204</sup>Pb)<i>t</i> = 36.324 to 37.064. Isotopic modelling indicates an origin that lies between mantle tapped by Cenozoic basalts around the Tan-Lu megafault and lower continental crust (LCC), and which can be explained by mixing of 11–18% mantle and 82–89% LCC. Based on new and compiled data, we suggest that the southern Jiaodong Peninsula, as well as the Laoshan area, was in a regional extensional setting of an orogenic belt during 106–126 Ma. The granitic rocks may be the result of late Mesozoic lithospheric thinning and decratonization (i.e. late Mesozoic craton destruction event occurring throughout eastern China).
DOI: 10.6084/m9.figshare.6292334
title: Yelp 2015

description: This dataset is a subset of the Yelp Challenge, it contains all the reviews in the year of 2015
DOI: 10.6084/m9.figshare.6292328
title: Mini-training on Open Identities

description: Mini-training delivered at the FOSTER Open Science Bootcamp in Barcelona from 18-20 April 2018 at the Centre for Genomic Regulation.
DOI: 10.6084/m9.figshare.6292328.v3
title: Mini-training on Open Identities

description: Mini-training delivered at the FOSTER Open Science Bootcamp in Barcelona from 18-20 April 2018 at the Centre for Genomic Regulation.
DOI: 10.6084/m9.figshare.6292328.v2
title: Mini-training on Open Identities

description: Mini-training delivered at the FOSTER Open Science Bootcamp in Barcelona from 18-20 April 2018 at the Centre for Genomic Regulation.
DOI: 10.6084/m9.figshare.6292280
title: R code from Quantifying uncertainty due to fission–fusion dynamics as a component of social complexity

description: Code to perform all analyses
DOI: 10.6084/m9.figshare.6292274
title: DataSet from More than a sum of parts: robust face recognition by integrating variation

description: Performance data for each participant in the face matching task
DOI: 10.6084/m9.figshare.6292274.v1
title: DataSet from More than a sum of parts: robust face recognition by integrating variation

description: Performance data for each participant in the face matching task
DOI: 10.6084/m9.figshare.6292253
title: Yelp 2014

description: This dataset is a sub dataset of the Yelp Challenge.
DOI: 10.6084/m9.figshare.6292253.v1
title: Untitled Item

description: This dataset is a sub dataset of the Yelp Challenge.
DOI: 10.6084/m9.figshare.6292238
title: testfile

description: testfile 1<br>
DOI: 10.6084/m9.figshare.6292238.v1
title: testfile

description: testfile 1<br>
DOI: 10.6084/m9.figshare.6292235
title: Data S5 from Sun basking fish benefit from body temperatures that are higher than ambient water

description: Data from physical model experiment used to generate the graphs in Figure S2
DOI: 10.6084/m9.figshare.6292235.v1
title: Data S5 from Sun basking fish benefit from body temperatures that are higher than ambient water

description: Data from physical model experiment used to generate the graphs in Figure S2
DOI: 10.6084/m9.figshare.6292232
title: Data S3 from Sun basking fish benefit from body temperatures that are higher than ambient water

description: Data from temperature logger experiments used to generate the graph in panel a Figure1
DOI: 10.6084/m9.figshare.6292232.v1
title: Data S3 from Sun basking fish benefit from body temperatures that are higher than ambient water

description: Data from temperature logger experiments used to generate the graph in panel a Figure1
DOI: 10.6084/m9.figshare.6292226
title: Data S6 from Sun basking fish benefit from body temperatures that are higher than ambient water

description: Data from physical model experiment used to generate the graphs in Figure S3
DOI: 10.6084/m9.figshare.6292226.v1
title: Data S6 from Sun basking fish benefit from body temperatures that are higher than ambient water

description: Data from physical model experiment used to generate the graphs in Figure S3
DOI: 10.6084/m9.figshare.6292223
title: Data S1 from Sun basking fish benefit from body temperatures that are higher than ambient water

description: List of carp individuals with information on sex, colour morph, length at onset, length at termination, bold shy data.
DOI: 10.6084/m9.figshare.6292223.v1
title: Data S1 from Sun basking fish benefit from body temperatures that are higher than ambient water

description: List of carp individuals with information on sex, colour morph, length at onset, length at termination, bold shy data.
DOI: 10.6084/m9.figshare.6292220
title: Data S4 from Sun basking fish benefit from body temperatures that are higher than ambient water

description: Data from temperature logger experiments used to generate the graph in panel b Figure 1 and the graphs in Figure S1
DOI: 10.6084/m9.figshare.6292220.v1
title: Data S4 from Sun basking fish benefit from body temperatures that are higher than ambient water

description: Data from temperature logger experiments used to generate the graph in panel b Figure 1 and the graphs in Figure S1
DOI: 10.6084/m9.figshare.6292217
title: Data S2 from Sun basking fish benefit from body temperatures that are higher than ambient water

description: Raw data from data storage tags
DOI: 10.6084/m9.figshare.6292217.v1
title: Data S2 from Sun basking fish benefit from body temperatures that are higher than ambient water

description: Raw data from data storage tags
DOI: 10.6084/m9.figshare.6292187
title: The relationship of ungulate δ13C and environment in the temperate biome of southern Africa, and its palaeoclimatic application

description: Supporting dataset for <b>"The relationship of ungulate d13C and environment in the temperate biome of Southern Africa, and its palaeoclimatic application" </b><b><br></b><i>Paleoclimatology, Paleoecology, Paleogeography </i>Vol 514, pp. 282-291<br><i><br></i>Julie Luyt*<sup>#</sup>, Vincent J. Hare*, Judith Sealy*<br>*Department of Archaeology, University of Cape Town<sup>#</sup>NRF-DST Centre of Excellence in Palaeosciences
DOI: 10.6084/m9.figshare.6292142
title: Yelp 2013

description: This dataset is a subset of the Yelp Challenge, it contains all the reviews in the year of 2013
DOI: 10.6084/m9.figshare.6292106
title: Energy Sector in India

description: Conducting an academic research on blockchain technology in energy sector of India
DOI: 10.6084/m9.figshare.6292106.v1
title: Energy Sector in India

description: Conducting an academic research on blockchain technology in energy sector of India
DOI: 10.6084/m9.figshare.6292058
title: Data directory for NSPN manuscript "Adolescence is associated with genomically patterned consolidation of the hubs of the human brain connectome".

description: This zipped directory contains all the data required to reproduce the analyses in "Adolescence is associated with genomically patterned consolidation of the hubs of the human brain connectome".<br><br>
DOI: 10.6084/m9.figshare.6292040
title: C. PIPIENS WOLBACHIA MAGs

description: <b>Wolbachia metagenome-assembled genomes reconstructed from individual Culex pipens ovaries.</b><br>Details of the study and a reproducible bioinformatics workflow:<br>http://merenlab.org/data/wolbachia-plasmid/<br><br>All public data files in this collection:<br>https://figshare.com/projects/A_Wolbachia_Plasmid_by_Reveillaud_and_Bordenstein_et_al_2018_/32069
DOI: 10.6084/m9.figshare.6291833
title: Species list and abundance of home garden plants in Jeju, South Korea

description: All plants that occurred in home gardens (n=133) in Jeju, South Korea, home gardens randomly selected, 12 villages, 10-12 gardens per village, June-August 2015, folk identification (identified by the garden tender)
DOI: 10.6084/m9.figshare.6291803
title: E coli strain MEEI01 simulated reads

description: Simulated Illumina reads from E coli MEEI01 genome. Simulation performed using ART - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3278762/<br>Read length = 250bpFold coverage (sequencing depth) = 200Mean insert size = 600bpStandard deviation of insert size = 10<br>`art_illumina -i MEEI01.fna -l 250 -p -f 200 -m 600 -s 10 -o paired_dat`<br>
DOI: 10.6084/m9.figshare.6291803.v1
title: E coli strain MEEI01 simulated reads

description: Simulated Illumina reads from E coli MEEI01 genome. Simulation performed using ART - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3278762/<br>Read length = 250bpFold coverage (sequencing depth) = 200Mean insert size = 600bpStandard deviation of insert size = 10<br>`art_illumina -i MEEI01.fna -l 250 -p -f 200 -m 600 -s 10 -o paired_dat`<br>
DOI: 10.6084/m9.figshare.6291794
title: Additional file 1: of Tropical ash (Fraxinus udhei) invading Andean forest remnants in Northern South America

description: Dataset of tropical ash individuals. (XLSX 86 kb)
DOI: 10.6084/m9.figshare.6291794.v1
title: Additional file 1: of Tropical ash (Fraxinus udhei) invading Andean forest remnants in Northern South America

description: Dataset of tropical ash individuals. (XLSX 86 kb)
DOI: 10.6084/m9.figshare.6291785
title: Meital et al, Raw data.xlsx

description: Raw data for the following data sets: Plasma TNF, Plasma IL-6, Plasma IL-1B, Plasma IL-10, Plasma TGF-beta, Plasma MMP-9, Macrophage supernatant IL-6, Macrophage supernatant TNF, Macrophage supernatant IL-1B, Macrophage supernatant IL-10, Macrophage supernatant TGF beta, GPX macrophage membrane, Plasma GPx, Plasma catalase, Macrophage membrane catalase, Plasma 8-isoprostane, Western blot catalase, Western blot GPx, Western blot MMP-9, Plasma PGE2.