cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.60712/si-id299393.2
title: StrainInfo SI-ID 299393.2

description: StrainInfo dataset 299393 about a strain of Saccharomyces cerevisiae. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data.
DOI: 10.60712/si-id299394.2
title: StrainInfo SI-ID 299394.2

description: StrainInfo dataset 299394 about a strain of Saccharomyces cerevisiae. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data.
DOI: 10.60712/si-id299395.2
title: StrainInfo SI-ID 299395.2

description: StrainInfo dataset 299395 about a strain of Saccharomyces cerevisiae. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data.
DOI: 10.60712/si-id299397.2
title: StrainInfo SI-ID 299397.2

description: StrainInfo dataset 299397 about a strain of Stachybotrys chartarum. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data.
DOI: 10.60712/si-id299398.2
title: StrainInfo SI-ID 299398.2

description: StrainInfo dataset 299398 about a strain of Stachybotrys chartarum. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data.
DOI: 10.60712/si-id299399.2
title: StrainInfo SI-ID 299399.2

description: StrainInfo dataset 299399 about a strain of Schizosaccharomyces pombe. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data.
DOI: 10.60712/si-id299400.2
title: StrainInfo SI-ID 299400.2

description: StrainInfo dataset 299400 about a strain of Lomentospora prolificans. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data.
DOI: 10.60712/si-id299404.3
title: StrainInfo SI-ID 299404.3

description: StrainInfo dataset 299404 about a strain of a not identified species. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data.
DOI: 10.60712/si-id299411.2
title: StrainInfo SI-ID 299411.2

description: StrainInfo dataset 299411 about a strain of Kluyveromyces marxianus. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data.
DOI: 10.60712/si-id299412.2
title: StrainInfo SI-ID 299412.2

description: StrainInfo dataset 299412 about a strain of Pichia kudriavzevii. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data.
DOI: 10.60712/si-id299413.2
title: StrainInfo SI-ID 299413.2

description: StrainInfo dataset 299413 about a strain of Brettanomyces bruxellensis. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data.
DOI: 10.60712/si-id299414.2
title: StrainInfo SI-ID 299414.2

description: StrainInfo dataset 299414 about a strain of a not identified species. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data.
DOI: 10.60712/si-id299415.2
title: StrainInfo SI-ID 299415.2

description: StrainInfo dataset 299415 about a strain of Aspergillus niger. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data.
DOI: 10.60712/si-id299428.2
title: StrainInfo SI-ID 299428.2

description: StrainInfo dataset 299428 about a strain of Lachnum spartinae. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data.
DOI: 10.60712/si-id299434.2
title: StrainInfo SI-ID 299434.2

description: StrainInfo dataset 299434 about a strain of Ascovaginospora stellipala. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data.
DOI: 10.60712/si-id299435.3
title: StrainInfo SI-ID 299435.3

description: StrainInfo dataset 299435 about a strain of Plenodomus lingam. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data.
DOI: 10.60712/si-id299439.3
title: StrainInfo SI-ID 299439.3

description: StrainInfo dataset 299439 about a strain of Aureobasidium pullulans. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data.
DOI: 10.60712/si-id299440.2
title: StrainInfo SI-ID 299440.2

description: StrainInfo dataset 299440 about a strain of Jamesozyma lodderae. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data.
DOI: 10.60712/si-id299441.2
title: StrainInfo SI-ID 299441.2

description: StrainInfo dataset 299441 about a strain of Kluyveromyces lactis. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data.
DOI: 10.60712/si-id299442.2
title: StrainInfo SI-ID 299442.2

description: StrainInfo dataset 299442 about a strain of Marchandiomyces corallinus. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data.
DOI: 10.6084/m9.figshare.28368307
title: Aminofullerenes as targeted inhibitors of EGFR: from pancreatic cancer inhibitors to <i>Drosophila m</i>. Toxicology

description: Pancreatic ductal adenocarcinoma (PDAC) is recognized as one of the most formidable cancers, largely due to its distinct microenvironment characterized predominantly by extensive desmoplastic stroma. In this study, we synthesized three novel water-soluble fullerene-based nanomaterials targeting EGFR protein. The direct amination of fullerene carbon atoms, was followed by conjugation with a modified derivative of the EGFR inhibitor-erlotinib, resulting in the formation of novel water-soluble fullerene derivatives. Further investigation into PAN02 and AsPC-1 cell lines revealed that these fullerene nanomaterials could induce cell cycle arrest in the G0/G1 phase, corroborated by alterations in the expression levels of the p27 and cyclin E1 proteins. Additionally, mechanisms of cell death were identified as autophagy for C<sub>60</sub>BUT and C<sub>70</sub>BUT-ERL, and apoptosis for Gd@C<sub>82</sub>EDA-ERL nanomaterials. Crucially, the study uncovered the efficacy of synthesized aminofullerenes in inhibiting the EGFR signaling pathway. The further toxicological studies of Gd@C<sub>82</sub>EDA-ERL fullerene on <i>Drosophila melanogaster</i>, underscored its potential for theranostic applications.
DOI: 10.6084/m9.figshare.28368307.v1
title: Aminofullerenes as targeted inhibitors of EGFR: from pancreatic cancer inhibitors to <i>Drosophila m</i>. Toxicology

description: Pancreatic ductal adenocarcinoma (PDAC) is recognized as one of the most formidable cancers, largely due to its distinct microenvironment characterized predominantly by extensive desmoplastic stroma. In this study, we synthesized three novel water-soluble fullerene-based nanomaterials targeting EGFR protein. The direct amination of fullerene carbon atoms, was followed by conjugation with a modified derivative of the EGFR inhibitor-erlotinib, resulting in the formation of novel water-soluble fullerene derivatives. Further investigation into PAN02 and AsPC-1 cell lines revealed that these fullerene nanomaterials could induce cell cycle arrest in the G0/G1 phase, corroborated by alterations in the expression levels of the p27 and cyclin E1 proteins. Additionally, mechanisms of cell death were identified as autophagy for C<sub>60</sub>BUT and C<sub>70</sub>BUT-ERL, and apoptosis for Gd@C<sub>82</sub>EDA-ERL nanomaterials. Crucially, the study uncovered the efficacy of synthesized aminofullerenes in inhibiting the EGFR signaling pathway. The further toxicological studies of Gd@C<sub>82</sub>EDA-ERL fullerene on <i>Drosophila melanogaster</i>, underscored its potential for theranostic applications.
DOI: 10.6084/m9.figshare.28398047
title: Dopamine stabilized in ultra-nanoreservoirs for controlled delivery in parkinson’s disease

description: Parkinson’s disease (PD) is a neurodegenerative disorder caused by the progressive degeneration of dopaminergic neurons in the substantia nigra pars compacta, leading to impaired dopamine (DA) signaling and motor control. Intermittent dosing of current DA precursors results in side effects, prompting research into controlled drug release mechanisms for sustained and targeted delivery of DA. In this work, we stabilized DA within a nanostructured silicate matrix (nanoreservoir) using the sol-gel method. We examined the physicochemical properties, kinetics of drug release, and biocompatibility in dopaminergic neurons and fibroblasts. The optimized synthesis method allowed for the stabilization of DA by preventing its oxidation. The physicochemical and controlled release analysis showed a direct relationship between the mesoporous structure, interaction of the DA with the matrix, and the release kinetics followed, proving the possibility to modify the rate of release by adjusting the synthesis parameters. Furthermore, the nanoreservoirs were biocompatible with dopaminergic neurons and fibroblasts <i>in vitro.</i> The research sets the stage for potential <i>in vivo</i> evaluations and new strategies for managing PD, offering hope for improved treatments based on DA and not derivatives.
DOI: 10.6084/m9.figshare.28398047.v1
title: Dopamine stabilized in ultra-nanoreservoirs for controlled delivery in parkinson’s disease

description: Parkinson’s disease (PD) is a neurodegenerative disorder caused by the progressive degeneration of dopaminergic neurons in the substantia nigra pars compacta, leading to impaired dopamine (DA) signaling and motor control. Intermittent dosing of current DA precursors results in side effects, prompting research into controlled drug release mechanisms for sustained and targeted delivery of DA. In this work, we stabilized DA within a nanostructured silicate matrix (nanoreservoir) using the sol-gel method. We examined the physicochemical properties, kinetics of drug release, and biocompatibility in dopaminergic neurons and fibroblasts. The optimized synthesis method allowed for the stabilization of DA by preventing its oxidation. The physicochemical and controlled release analysis showed a direct relationship between the mesoporous structure, interaction of the DA with the matrix, and the release kinetics followed, proving the possibility to modify the rate of release by adjusting the synthesis parameters. Furthermore, the nanoreservoirs were biocompatible with dopaminergic neurons and fibroblasts <i>in vitro.</i> The research sets the stage for potential <i>in vivo</i> evaluations and new strategies for managing PD, offering hope for improved treatments based on DA and not derivatives.
DOI: 10.60712/si-id299444.2
title: StrainInfo SI-ID 299444.2

description: StrainInfo dataset 299444 about a strain of Coriolopsis trogii. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data.
DOI: 10.6084/m9.figshare.28343580
title: A nano drug delivery system loading drugs and chlorin e6 separately to achieve photodynamic-chemo combination therapy

description: To develop a new drug delivery system (DDS) that can load chemotherapy agents and photosensitizer chlorin e6 (Ce6) onto the pores and surfaces of mesoporous silica nanoparticle (MSN) separately. Doxorubicin (DOX) was loaded into the pores of MSNs. Then, polyethyleneimine (PEI) was used to coat the surface of MSN to protect DOX, and then manganese dioxide (MnO<sub>2</sub>) nanoparticles were loaded through adding potassium permanganate (KMnO<sub>4</sub>) to bind with Ce6. Finally, polydopamine (PDA) was coated and coupled with hyaluronic acid (HA). The synthesized versatile nanoparticle was pH-sensitive and exhibited positive photodynamic therapy (PDT) performance. Besides, it could be observed that the nanoparticles were efficiently taken up by tumor cells through confocal laser scanning microscopy (CLSM) and flow cytometry. Additionally, in vitro experiments suggested that the nanoparticles had pleasing toxicity to various tumor cells and equally positive therapeutic effect when curcumin replaced DOX. Our work suggests that the nanoparticles designed by our strategy have satisfactory combination therapy performance and can enable more chemotherapy drugs to be used in photodynamic-chemo combination therapy.
DOI: 10.6084/m9.figshare.28343580.v1
title: A nano drug delivery system loading drugs and chlorin e6 separately to achieve photodynamic-chemo combination therapy

description: To develop a new drug delivery system (DDS) that can load chemotherapy agents and photosensitizer chlorin e6 (Ce6) onto the pores and surfaces of mesoporous silica nanoparticle (MSN) separately. Doxorubicin (DOX) was loaded into the pores of MSNs. Then, polyethyleneimine (PEI) was used to coat the surface of MSN to protect DOX, and then manganese dioxide (MnO<sub>2</sub>) nanoparticles were loaded through adding potassium permanganate (KMnO<sub>4</sub>) to bind with Ce6. Finally, polydopamine (PDA) was coated and coupled with hyaluronic acid (HA). The synthesized versatile nanoparticle was pH-sensitive and exhibited positive photodynamic therapy (PDT) performance. Besides, it could be observed that the nanoparticles were efficiently taken up by tumor cells through confocal laser scanning microscopy (CLSM) and flow cytometry. Additionally, in vitro experiments suggested that the nanoparticles had pleasing toxicity to various tumor cells and equally positive therapeutic effect when curcumin replaced DOX. Our work suggests that the nanoparticles designed by our strategy have satisfactory combination therapy performance and can enable more chemotherapy drugs to be used in photodynamic-chemo combination therapy.
DOI: 10.60712/si-id299445.2
title: StrainInfo SI-ID 299445.2

description: StrainInfo dataset 299445 about a strain of Trametes versicolor. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data.
DOI: 10.60712/si-id299451.2
title: StrainInfo SI-ID 299451.2

description: StrainInfo dataset 299451 about a strain of Saccharomyces cerevisiae. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data.
DOI: 10.60712/si-id299453.2
title: StrainInfo SI-ID 299453.2

description: StrainInfo dataset 299453 about a strain of Saccharomyces cerevisiae. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data.
DOI: 10.60712/si-id299456.2
title: StrainInfo SI-ID 299456.2

description: StrainInfo dataset 299456 about a strain of Saccharomyces cerevisiae. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data.
DOI: 10.60712/si-id299459.2
title: StrainInfo SI-ID 299459.2

description: StrainInfo dataset 299459 about a strain of Scheffersomyces stipitis. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data.
DOI: 10.60712/si-id299460.2
title: StrainInfo SI-ID 299460.2

description: StrainInfo dataset 299460 about a strain of Saccharomyces cerevisiae. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data.
DOI: 10.60712/si-id299461.2
title: StrainInfo SI-ID 299461.2

description: StrainInfo dataset 299461 about a strain of Saccharomyces cerevisiae. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data.
DOI: 10.60712/si-id299462.2
title: StrainInfo SI-ID 299462.2

description: StrainInfo dataset 299462 about a strain of Saccharomyces cerevisiae. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data.
DOI: 10.60712/si-id299463.2
title: StrainInfo SI-ID 299463.2

description: StrainInfo dataset 299463 about a strain of Saccharomyces cerevisiae. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data.
DOI: 10.60712/si-id299464.2
title: StrainInfo SI-ID 299464.2

description: StrainInfo dataset 299464 about a strain of Saccharomyces cerevisiae. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data.
DOI: 10.60712/si-id299465.2
title: StrainInfo SI-ID 299465.2

description: StrainInfo dataset 299465 about a strain of Saccharomyces cerevisiae. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data.
DOI: 10.60712/si-id299466.2
title: StrainInfo SI-ID 299466.2

description: StrainInfo dataset 299466 about a strain of Saccharomyces cerevisiae. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data.
DOI: 10.15151/esrf-es-2009544004
title: X-ray Raman scattering, X-ray emission and optical spectroscopy of matter at extreme conditions: Structure of melts and molecular compounds

description: This long term project aims for the implementation of a power-stabilized CO2 laser heating setup coupled to diamond anvil cell technique and optical Raman spectroscopy at the X-ray Raman spectrometer of beamline ID20 of ESRF. This instrumentation will enable unique in-situ studies of low-Z element compounds at extreme conditions, extracting information of local and long-range structure as well as electronic properties of disordered matter. We aim to explore silicate glasses and melts in order to reveal the structure and electronic state of relevant magmas. Second, we will investigate the chemistry of the light compounds H2O, CO2 and NH3 at extreme conditions which is highly relevant for the dynamics and formation of giant-gas and most exoplanets. The setup will significantly extend the capabilities of beamline ID20 and cross not only new frontiers in geoscientific applications but addresses likewise a broad user-base in diverse areas such as chemistry, physics and materials science.
DOI: 10.60712/si-id299467.2
title: StrainInfo SI-ID 299467.2

description: StrainInfo dataset 299467 about a strain of Saccharomyces cerevisiae. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data.
DOI: 10.60712/si-id299468.2
title: StrainInfo SI-ID 299468.2

description: StrainInfo dataset 299468 about a strain of Pyricularia oryzae. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data.
DOI: 10.60712/si-id299469.2
title: StrainInfo SI-ID 299469.2

description: StrainInfo dataset 299469 about a strain of Saccharomyces cerevisiae. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data.
DOI: 10.60712/si-id299470.2
title: StrainInfo SI-ID 299470.2

description: StrainInfo dataset 299470 about a strain of Saccharomyces cerevisiae. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data.
DOI: 10.60712/si-id299471.2
title: StrainInfo SI-ID 299471.2

description: StrainInfo dataset 299471 about a strain of Saccharomyces cerevisiae. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data.
DOI: 10.60712/si-id299472.2
title: StrainInfo SI-ID 299472.2

description: StrainInfo dataset 299472 about a strain of Yarrowia lipolytica. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data.
DOI: 10.60712/si-id299473.2
title: StrainInfo SI-ID 299473.2

description: StrainInfo dataset 299473 about a strain of Yarrowia lipolytica. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data.
DOI: 10.60712/si-id299474.2
title: StrainInfo SI-ID 299474.2

description: StrainInfo dataset 299474 about a strain of Yarrowia lipolytica. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data.
DOI: 10.60712/si-id299475.2
title: StrainInfo SI-ID 299475.2

description: StrainInfo dataset 299475 about a strain of Yarrowia lipolytica. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data.
DOI: 10.60712/si-id299476.2
title: StrainInfo SI-ID 299476.2

description: StrainInfo dataset 299476 about a strain of Yarrowia lipolytica. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data.
DOI: 10.60712/si-id299477.2
title: StrainInfo SI-ID 299477.2

description: StrainInfo dataset 299477 about a strain of Yarrowia lipolytica. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data.
DOI: 10.60712/si-id299478.2
title: StrainInfo SI-ID 299478.2

description: StrainInfo dataset 299478 about a strain of Saccharomyces cerevisiae. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data.
DOI: 10.60712/si-id299479.2
title: StrainInfo SI-ID 299479.2

description: StrainInfo dataset 299479 about a strain of Saccharomyces cerevisiae. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data.