cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.2067450
title: Online Updating of Statistical Inference in the Big Data Setting

description: We present statistical methods for big data arising from online analytical processing, where large amounts of data arrive in streams and require fast analysis without storage/access to the historical data. In particular, we develop iterative estimating algorithms and statistical inferences for linear models and estimating equations that update as new data arrive. These algorithms are computationally efficient, minimally storage-intensive, and allow for possible rank deficiencies in the subset design matrices due to rare-event covariates. Within the linear model setting, the proposed online-updating framework leads to predictive residual tests that can be used to assess the goodness of fit of the hypothesized model. We also propose a new online-updating estimator under the estimating equation setting. Theoretical properties of the goodness-of-fit tests and proposed estimators are examined in detail. In simulation studies and real data applications, our estimator compares favorably with competing approaches under the estimating equation setting. Supplementary materials for this article are available online.
DOI: 10.6084/m9.figshare.2067450.v1
title: Online Updating of Statistical Inference in the Big Data Setting

description: We present statistical methods for big data arising from online analytical processing, where large amounts of data arrive in streams and require fast analysis without storage/access to the historical data. In particular, we develop iterative estimating algorithms and statistical inferences for linear models and estimating equations that update as new data arrive. These algorithms are computationally efficient, minimally storage-intensive, and allow for possible rank deficiencies in the subset design matrices due to rare-event covariates. Within the linear model setting, the proposed online-updating framework leads to predictive residual tests that can be used to assess the goodness of fit of the hypothesized model. We also propose a new online-updating estimator under the estimating equation setting. Theoretical properties of the goodness-of-fit tests and proposed estimators are examined in detail. In simulation studies and real data applications, our estimator compares favorably with competing approaches under the estimating equation setting. Supplementary materials for this article are available online.
DOI: 10.6084/m9.figshare.2067870
title: A review on the salt bridge ASP177-ARG163 (O–N) of wild-type rabbit prion protein

description: A review on the salt bridge ASP177-ARG163 (O–N) of wild-type rabbit prion protein
DOI: 10.6084/m9.figshare.2067870.v1
title: A review on the salt bridge ASP177-ARG163 (O–N) of wild-type rabbit prion protein

description: A review on the salt bridge ASP177-ARG163 (O–N) of wild-type rabbit prion protein
DOI: 10.6084/m9.figshare.2067984.v1
title: A crystalline bisindolylmaleimide with strong solid-state fluorescence of red color and its analogous cross-linked polymer without fluorescence

description: A crystalline bisindolylmaleimide (BIM) <b>3</b> with strong fluorescence in the solid state was prepared and studied. Its analogous cross-linked polymer <b>4</b> with the same BIMs fluorophore was designed and characterized. The investigation of the covalent bonding networking effect on the solid-state fluorescence was carried out by the comparison between <b>3</b> and <b>4</b>.
DOI: 10.6084/m9.figshare.2068248
title: System Reliability and Component Importance Under Dependence: A Copula Approach

description: System reliability and component importance are of great interest in reliability modeling, especially when the components within the system are dependent. We characterize the influence of dependence structures on system reliability and component importance in coherent systems with discrete marginal distributions. The effects of dependence are captured through copula theory. We extend our framework to coherent multi-state system. Applications of the derived results are demonstrated using a Gaussian copula, which yields simple interpretations. Simulations and two examples are presented to demonstrate the importance of modeling dependence when estimating system reliability and ranking of component importance. Proofs, algorithms, code, and data are provided in supplementary materials available online.
DOI: 10.6084/m9.figshare.2068248.v1
title: System Reliability and Component Importance under Dependence: A Copula Approach

description: System reliability and component importance are of great interest in reliability modeling, especially when the components within the system are dependent. We characterize the influence of dependence structures on system reliability and component importance in coherent systems with discrete marginal distributions. The effects of dependence are captured through copula theory. We extend our framework to coherent multi-state system. Applications of the derived results are demonstrated using a Gaussian copula, which yields simple interpretations. Simulations and two examples are presented to demonstrate the importance of modeling dependence when estimating system reliability and ranking of component importance. Proofs, algorithms, code and data are provided in Supplementary Materials available online.
DOI: 10.6084/m9.figshare.2068248.v2
title: System Reliability and Component Importance Under Dependence: A Copula Approach

description: System reliability and component importance are of great interest in reliability modeling, especially when the components within the system are dependent. We characterize the influence of dependence structures on system reliability and component importance in coherent systems with discrete marginal distributions. The effects of dependence are captured through copula theory. We extend our framework to coherent multi-state system. Applications of the derived results are demonstrated using a Gaussian copula, which yields simple interpretations. Simulations and two examples are presented to demonstrate the importance of modeling dependence when estimating system reliability and ranking of component importance. Proofs, algorithms, code, and data are provided in supplementary materials available online.
DOI: 10.6084/m9.figshare.2068605
title: Fabrication of continuous slim aluminum fibers using a multi-tooth tool

description: In this paper, we describe the development of a multi-tooth tool to fabricate continuous, slim aluminum fibers of an equivalent diameter of under 100 µm. Following an analysis of the process of the fabrication of aluminum fibers, we designed a geometric cutting model of the multi-tooth tool with a large inclination as well as the mechanism to form continuous, slim aluminum fibers. We conducted experiments to determine the influence of process parameters on the surface topography and the equivalent diameter of the aluminum fiber. We obtained the continuous, slim aluminum fibers with a micro-fin structure when the cutting speed, cutting depth, and feed rate were in the ranges of 0.08–0.18 mm, 5–15 m/min, and 0.1–0.2 mm/r, respectively. We found that the equivalent diameter of the aluminum fiber gradually increased with decreasing cutting speed, and increasing feed rate and cutting depth. Moreover, the result of a composition analysis indicated that the generated cutting heat had a minimal effect on the oxidation of the aluminum fiber.
DOI: 10.6084/m9.figshare.2068605.v1
title: Fabrication of Continuous Slim Aluminum Fibers Using a Multi-tooth Tool

description: In this paper, we describe the development of a multi-tooth tool to fabricate continuous, slim aluminum fibers of an equivalent diameter of under 100 µm. Following an analysis of the process of the fabrication of aluminum fibers, we designed a geometric cutting model of the multi-tooth tool with a large inclination as well as the mechanism to form continuous, slim aluminum fibers. We conducted experiments to determine the influence of process parameters on the surface topography and the equivalent diameter of the aluminum fiber. We obtained the continuous, slim aluminum fibers with a micro-fin structure when the cutting speed, cutting depth and feed rate were in the ranges of 0.08–0.18 mm, 5–15 m/min and 0.1–0.2 mm/r, respectively. We found that the equivalent diameter of the aluminum fiber gradually increased with decreasing cutting speed, and increasing feed rate and cutting depth. Moreover, the result of a composition analysis indicated that the generated cutting heat had a minimal effect on the oxidation of the aluminum fiber.
DOI: 10.6084/m9.figshare.2068605.v2
title: Fabrication of continuous slim aluminum fibers using a multi-tooth tool

description: In this paper, we describe the development of a multi-tooth tool to fabricate continuous, slim aluminum fibers of an equivalent diameter of under 100 µm. Following an analysis of the process of the fabrication of aluminum fibers, we designed a geometric cutting model of the multi-tooth tool with a large inclination as well as the mechanism to form continuous, slim aluminum fibers. We conducted experiments to determine the influence of process parameters on the surface topography and the equivalent diameter of the aluminum fiber. We obtained the continuous, slim aluminum fibers with a micro-fin structure when the cutting speed, cutting depth, and feed rate were in the ranges of 0.08–0.18 mm, 5–15 m/min, and 0.1–0.2 mm/r, respectively. We found that the equivalent diameter of the aluminum fiber gradually increased with decreasing cutting speed, and increasing feed rate and cutting depth. Moreover, the result of a composition analysis indicated that the generated cutting heat had a minimal effect on the oxidation of the aluminum fiber.
DOI: 10.6084/m9.figshare.2068806
title: A novel mutation in <i>PAX3</i> associated with Waardenburg syndrome type I in a Chinese family

description: <b>Conclusion</b> The novel compound heterozygous mutation in <i>PAX3</i> was the key genetic reason for WS1 in this family, which was useful to the molecular diagnosis of WS1. <b>Purpose</b> Screening the pathogenic mutations in a four generation Chinese family with Waardenburg syndrome type I (WS1). <b>Methods</b> WS1 was diagnosed in a 4-year-old boy according to the Waardenburg syndrome Consortium criteria. The detailed family history revealed four affected members in the family. Routine clinical, audiological examination, and ophthalmologic evaluation were performed on four affected and 10 healthy members in this family. The genetic analysis was conducted, including the targeted next-generation sequencing of 127 known deafness genes combined with Sanger sequencing, TA clone and bioinformatic analysis. <b>Results</b> A novel compound heterozygous mutation c.[169_170insC;172_174delAAG] (p.His57ProfsX55) was identified in <i>PAX3</i>, which was co-segregated with WS1 in the Chinese family. This mutation was absent in the unaffected family members and 200 ethnicity-matched controls. The phylogenetic analysis and three-dimensional (3D) modeling of Pax3 protein further confirmed that the novel compound heterozygous mutation was pathogenic.
DOI: 10.6084/m9.figshare.2068806.v1
title: A novel mutation in <i>PAX3</i> associated with Waardenburg syndrome type I in a Chinese family

description: <b>Conclusion</b> The novel compound heterozygous mutation in <i>PAX3</i> was the key genetic reason for WS1 in this family, which was useful to the molecular diagnosis of WS1. <b>Purpose</b> Screening the pathogenic mutations in a four generation Chinese family with Waardenburg syndrome type I (WS1). <b>Methods</b> WS1 was diagnosed in a 4-year-old boy according to the Waardenburg syndrome Consortium criteria. The detailed family history revealed four affected members in the family. Routine clinical, audiological examination, and ophthalmologic evaluation were performed on four affected and 10 healthy members in this family. The genetic analysis was conducted, including the targeted next-generation sequencing of 127 known deafness genes combined with Sanger sequencing, TA clone and bioinformatic analysis. <b>Results</b> A novel compound heterozygous mutation c.[169_170insC;172_174delAAG] (p.His57ProfsX55) was identified in <i>PAX3</i>, which was co-segregated with WS1 in the Chinese family. This mutation was absent in the unaffected family members and 200 ethnicity-matched controls. The phylogenetic analysis and three-dimensional (3D) modeling of Pax3 protein further confirmed that the novel compound heterozygous mutation was pathogenic.
DOI: 10.6084/m9.figshare.2069585
title: Alcohol Dependence in Primary and Specialist Care in Europe - Data set

description: The dataset refers to the 'Alcohol Dependence in Primary and Specialist Care in Europe' study.<br><br>All data were collected in primary and specialized health care settings in 6/8 European countries. Please see the references for more details.<br><br>Primary care: Germany, Hungary, Italy, Latvia, Poland, Spain<br>Specialized care: Austria, France, Germany, Hungary, Italy, Latvia, Poland, Spain<br><br>The codebook includes all variables including variable labels. More information on design, sampling, and data collection can be found in the references.<br><br>For any question, please contact Jakob Manthey.<br>
DOI: 10.34740/kaggle/dsv/4853544
title: Cloud_Storage_Workload
DOI: 10.6084/m9.figshare.2069585.v1
title: APC_PC_SC_finalclean.dta

description: Data were collected in primary and specialized health care settings in 6 European countries. Please see the references for more details.<br>
DOI: 10.6084/m9.figshare.2069585.v2
title: APC_PC_SC_finalclean.dta

description: The dataset refers to the 'Alcohol Dependence in Primary and Specialist Care in Europe' study.<br><br>All data were collected in primary and specialized health care settings in 6/8 European countries. Please see the references for more details.<br><br>Primary care: Germany, Hungary, Italy, Latvia, Poland, Spain<br>Specialized care: Austria, France, Germany, Hungary, Italy, Latvia, Poland, Spain<br><br>The codebook includes all variables including variable labels. More information on design, sampling, and data collection can be found in the references.<br><br>For any question, please contact Jakob Manthey.<br>
DOI: 10.6084/m9.figshare.2069585.v3
title: APC_PC_SC_finalclean.dta

description: The dataset refers to the 'Alcohol Dependence in Primary and Specialist Care in Europe' study.<br><br>All data were collected in primary and specialized health care settings in 6/8 European countries. Please see the references for more details.<br><br>Primary care: Germany, Hungary, Italy, Latvia, Poland, Spain<br>Specialized care: Austria, France, Germany, Hungary, Italy, Latvia, Poland, Spain<br><br>The codebook includes all variables including variable labels. More information on design, sampling, and data collection can be found in the references.<br><br>For any question, please contact Jakob Manthey.<br>
DOI: 10.6084/m9.figshare.2069585.v4
title: APC_PC_SC_finalclean.dta

description: The dataset refers to the 'Alcohol Dependence in Primary and Specialist Care in Europe' study.<br><br>All data were collected in primary and specialized health care settings in 6/8 European countries. Please see the references for more details.<br><br>Primary care: Germany, Hungary, Italy, Latvia, Poland, Spain<br>Specialized care: Austria, France, Germany, Hungary, Italy, Latvia, Poland, Spain<br><br>The codebook includes all variables including variable labels. More information on design, sampling, and data collection can be found in the references.<br><br>For any question, please contact Jakob Manthey.<br>
DOI: 10.6084/m9.figshare.2069782
title: A new adult specimen of the basalmost ornithuromorph bird <i>Archaeorhynchus spathula</i> (Aves: Ornithuromorpha) and its implications for early avian ontogeny

description: Most living birds characteristically grow rapidly and reach adult size within a year. Nevertheless, little is known about how such an advanced developmental strategy evolved despite many discoveries of early fossil birds. Here we assess the long-bone histology from a new adult specimen of <i>Archaeorhynchus spathula</i>, the basalmost taxon of Ornithuromorpha. Ornithuromorpha is the most inclusive clade containing extant birds but not the Mesozoic Enantiornithes. Histological analysis reveals that the cortex is composed of parallel-fibred bone with three lines of arrested growth, indicative of slow and annually interrupted growth for this taxon. Such bone histology is significantly different from that of other known basal ornithuromorphs, but resembles that of enantiornithines, which leads us to suggest protracted slow growth in the common ancestor of Ornithuromorpha and Enantiornithes. The fusion sequence of the tarsometatarsus between Enantiornithes and Ornithuromorpha has long been hypothesized to be different and regarded as indicative that enantiornithines are not close relatives of ornithuromorphs. Due to a lack of fossils recording early ontogenetic stages, little is known about the development of the tarsometatarsus in basal ornithuromorphs, making this hypothesis impossible to test. Here we show that the fusion sequence of the tarsometatarsus in <i>Archaeorhynchus</i> is similar to that of enantiornithines, and that the proximal-early fusion in tarsometatarsus represents a plesiomorphic trait for basal birds. Our findings also shed light on ontogenetic variation of sternal morphology, which highlights the importance of ontogeny in the taxonomic and phylogenetic study of early birds.
DOI: 10.6084/m9.figshare.2069782.v1
title: A new adult specimen of the basalmost ornithuromorph bird <i>Archaeorhynchus spathula</i> (Aves: Ornithuromorpha) and its implications for early avian ontogeny

description: Most living birds characteristically grow rapidly and reach adult size within a year. Nevertheless, little is known about how such an advanced developmental strategy evolved despite many discoveries of early fossil birds. Here we assess the long-bone histology from a new adult specimen of <i>Archaeorhynchus spathula</i>, the basalmost taxon of Ornithuromorpha. Ornithuromorpha is the most inclusive clade containing extant birds but not the Mesozoic Enantiornithes. Histological analysis reveals that the cortex is composed of parallel-fibred bone with three lines of arrested growth, indicative of slow and annually interrupted growth for this taxon. Such bone histology is significantly different from that of other known basal ornithuromorphs, but resembles that of enantiornithines, which leads us to suggest protracted slow growth in the common ancestor of Ornithuromorpha and Enantiornithes. The fusion sequence of the tarsometatarsus between Enantiornithes and Ornithuromorpha has long been hypothesized to be different and regarded as indicative that enantiornithines are not close relatives of ornithuromorphs. Due to a lack of fossils recording early ontogenetic stages, little is known about the development of the tarsometatarsus in basal ornithuromorphs, making this hypothesis impossible to test. Here we show that the fusion sequence of the tarsometatarsus in <i>Archaeorhynchus</i> is similar to that of enantiornithines, and that the proximal-early fusion in tarsometatarsus represents a plesiomorphic trait for basal birds. Our findings also shed light on ontogenetic variation of sternal morphology, which highlights the importance of ontogeny in the taxonomic and phylogenetic study of early birds.
DOI: 10.6084/m9.figshare.2069929
title: Transgenic expression of <i>Dendrolimus kikuchii</i> nucleopolyhedrovirus enhancin in tobacco enhances the mortality and affects the development of <i>Spodoptera exigua</i> larvae

description: A novel 2551-bp enhancin gene designated <i>En-Dk</i> was isolated from the <i>Dendrolimus kikuchii</i> nucleopolyhedrovirus genome<i>.</i> Sequence analysis revealed that <i>En-Dk</i> encodes a polypeptide chain of 792 amino acid residues containing a conserved enhancin domain and an α-helical transmembrane domain, but no signal peptide. Compared with wild-type tobacco (<i>Nicotiana tabacum</i> L.), transgenic tobacco showed significant phenotypic changes following <i>En-Dk</i> overexpression with slower growth and delayed initial flowering. An interesting finding is that the transgenic tobacco exerted a toxic effect on newly hatched <i>Spodoptera exigua</i> larvae, with a significant inhibitory effect on third-instar larvae in terms of body weight, pupal weight, pupation and the emergence process.
DOI: 10.6084/m9.figshare.2069929.v1
title: Transgenic expression of <i>Dendrolimus kikuchii</i> nucleopolyhedrovirus enhancin in tobacco enhances the mortality and affects the development of <i>Spodoptera exigua</i> larvae

description: A novel 2551-bp enhancin gene designated <i>En-Dk</i> was isolated from the <i>Dendrolimus kikuchii</i> nucleopolyhedrovirus genome<i>.</i> Sequence analysis revealed that <i>En-Dk</i> encodes a polypeptide chain of 792 amino acid residues containing a conserved enhancin domain and an α-helical transmembrane domain, but no signal peptide. Compared with wild-type tobacco (<i>Nicotiana tabacum</i> L.), transgenic tobacco showed significant phenotypic changes following <i>En-Dk</i> overexpression with slower growth and delayed initial flowering. An interesting finding is that the transgenic tobacco exerted a toxic effect on newly hatched <i>Spodoptera exigua</i> larvae, with a significant inhibitory effect on third-instar larvae in terms of body weight, pupal weight, pupation and the emergence process.
DOI: 10.6084/m9.figshare.2073541
title: Identification of new candidate drugs for lung cancer using chemical–chemical interactions, chemical–protein interactions and a K-means clustering algorithm

description: Lung cancer, characterized by uncontrolled cell growth in the lung tissue, is the leading cause of global cancer deaths. Until now, effective treatment of this disease is limited. Many synthetic compounds have emerged with the advancement of combinatorial chemistry. Identification of effective lung cancer candidate drug compounds among them is a great challenge. Thus, it is necessary to build effective computational methods that can assist us in selecting for potential lung cancer drug compounds. In this study, a computational method was proposed to tackle this problem. The chemical–chemical interactions and chemical–protein interactions were utilized to select candidate drug compounds that have close associations with approved lung cancer drugs and lung cancer-related genes. A permutation test and K-means clustering algorithm were employed to exclude candidate drugs with low possibilities to treat lung cancer. The final analysis suggests that the remaining drug compounds have potential anti-lung cancer activities and most of them have structural dissimilarity with approved drugs for lung cancer.
DOI: 10.6084/m9.figshare.2073541.v1
title: Identification of new candidate drugs for lung cancer using chemical–chemical interactions, chemical–protein interactions and a K-means clustering algorithm

description: Lung cancer, characterized by uncontrolled cell growth in the lung tissue, is the leading cause of global cancer deaths. Until now, effective treatment of this disease is limited. Many synthetic compounds have emerged with the advancement of combinatorial chemistry. Identification of effective lung cancer candidate drug compounds among them is a great challenge. Thus, it is necessary to build effective computational methods that can assist us in selecting for potential lung cancer drug compounds. In this study, a computational method was proposed to tackle this problem. The chemical–chemical interactions and chemical–protein interactions were utilized to select candidate drug compounds that have close associations with approved lung cancer drugs and lung cancer-related genes. A permutation test and K-means clustering algorithm were employed to exclude candidate drugs with low possibilities to treat lung cancer. The final analysis suggests that the remaining drug compounds have potential anti-lung cancer activities and most of them have structural dissimilarity with approved drugs for lung cancer.