cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.7969646.v1
title: Supplementary Material for: Observational Study to Assess Quality of Life in Patients with Pancreatic Neuroendocrine Tumors Receiving Treatment with Everolimus: The OBLIQUE Study (UK Phase IV Trial)

description: <b><i>Background/Aims:</i></b> To assess health-related quality of life (HRQoL), treatment patterns, and clinical outcomes of adult (≥18 years) patients with advanced (unresectable or metastatic) pancreatic neuroendocrine neoplasms (PanNENs) treated with everolimus in routine clinical practice. <b><i>Methods:</i></b> In a prospective, non-interventional, multi-center study patients administered at least one 10 mg dose of everolimus were evaluated for change in HRQoL (EORTC QLQ-C30 Global Health Status scale) from baseline after 6 months treatment (primary endpoint). Secondary endpoints included disease-specific HRQoL measures (EORTC QLQ-G.I.NET21), clinical outcomes, everolimus treatment patterns, and safety. <b><i>Results:</i></b> Forty-eight patients were recruited (between August 2013 and March 2015); the median treatment duration was 27.8 months. EORTC QLQ-C30 Global Health score was not significantly different from baseline after 6 months of treatment (mean difference –1.9 points, <i>p</i> = 0.660, <i>n</i> = 30). In pairwise analyses, the only significant changes in HRQoL from baseline were for EORTC QLQ-C30 physical functioning score at month 3 (adjusted mean difference –8.8 points, <i>p</i> = 0.002, <i>n</i> = 36) and the EORTC QLQ-G.I.NET21 disease-related worries scores at months 1 and 2 (adjusted mean differences: –11.5 points [<i>p</i> = 0.001, <i>n</i> = 44] and –8.8 points [<i>p</i> = 0.017, <i>n</i> = 43], respectively). Disease progression or death was recorded in 44.4% (<i>n</i> = 20/45) patients during follow-up; median progression-free survival was 25.1 months and the cumulative survival rate at 3 years was 71%. No new safety signals were detected. <b><i>Conclusions:</i></b> The OBLIQUE study demonstrates that HRQoL is maintained in patients with PanNENs during treatment with everolimus in a UK real-world setting. This study adds to the limited HRQoL data available in this patient group.
DOI: 10.6084/m9.figshare.7969685.v1
title: Development, characterization, swelling, and network parameters of amino acid grafted guar gum based pH responsive polymeric hydrogels

description: This study includes the synthesis of graft copolymer (GG-g-PAPA) from N-Acryloyl-L-phenylalanine (APA) and guar gum through free radical polymerization. Then, the novel pH sensitive GG-g-PAPA-<i>cl</i>-(PHEA-<i>co</i>-PAMPS) [GGAH] polymeric hydrogels were synthesized by employing free radical cross-linking polymerization using graft copolymer, 2-acrylamido-2-methyl-1-propanesulfonic acid (AMPS), and 2-hydroxy ethyl acrylate (HEA). The GGAH hydrogels were characterized using FTIR and SEM. Swelling studies of GGAH hydrogels were performed in distilled water, pH 1.2, and pH 7.4 solutions. The network and swelling kinetic parameters of GGAH hydrogels are also calculated.
DOI: 10.6084/m9.figshare.7969502
title: Supplementary Material for: Human Mast Cell Sensitization with IgE Increases miRNA-210 Expression

description: <b><i>Background:</i></b> MicroRNAs (miRNAs) represent important post-transcriptional regulators with a dynamic expression profile during health and disease. <b><i>Objectives:</i></b> We explored the miRNA profile of human mast cells (MCs) during sen­sitization with IgE, during activation through IgE, and relat ed it to prostaglandin D<sub>2</sub> synthesis and histamine release. <b><i>Method:</i></b> We investigated the expression pattern of 762 miRNAs during the IgE-mediated sensitization and activation of MCs cultured from CD133+ stem cells that were isolated from allergic asthmatic patients and nonatopic controls. <b><i>Results:</i></b> IgE-mediated sensitization increased the expression of miRNA-210 eight-fold. This increase was sustained during IgE-mediated MC activation. Furthermore, we confirmed the increase of the miRNA-132/212 cluster after MC activation. Predicted target genes of miRNA-210/132/212 were enriched in several pathways known to be involved in MC activation. Histamine release was significantly higher in MCs from allergic patients when compared to controls, and a number of miRNAs correlated with histamine release and prostaglandin D<sub>2</sub> synthesis during MC activation. <b><i>Conclusion:</i></b> The miRNAs and analysis presented here can help to elucidate the role of miRNAs in mediator release during MC activation. We speculate that miRNA-210 could be important in MC sensitization that leads to allergic symptoms.
DOI: 10.6084/m9.figshare.7969535
title: Comprehensive nuclear proteome of <i>Arabidopsis</i> obtained by sequential extraction

description: In eukaryotes, the nucleus plays key roles in fundamental cellular processes, including DNA replication, chromatin maintenance, transcription, and translation. To better understand the functional diversity of nuclei, we developed a method for the comprehensive extraction of the nuclear proteome from <i>Arabidopsis</i>. We used a buffer with a high sucrose concentration to purify nuclei and then conducted solubility-based fractionation to increase proteome coverage. We identified 1539 proteins and two novel nuclear envelope (NE) proteins in the nuclear fraction of <i>Arabidopsis</i> cultured cells. The localization of 25 proteins was determined by GFP fusion analyses; 23 of these proteins were localized either in the nucleus or the NE-associated endoplasmic reticulum. This result was indicative of the high quality of the proteome. These findings will be useful for clarifying novel nuclear functions in plants.
DOI: 10.6084/m9.figshare.7969628
title: Supplementary Material for: Comorbidity of Vitamin A and Vitamin D Deficiency Exacerbates the Severity of Atopic Dermatitis in Children

description: <b><i>Background:</i></b> Several studies have suggested that vitamin D (VD) deficiency (VDD) is associated with atopic dermatitis (AD). However, little is known about the relationship between AD and vitamin A (VA). The interaction between VA and VD on AD requires further study. <b><i>Objective:</i></b> We detected serum levels of VA and VD in children with AD to explore how VA deficiency (VAD) and VDD affect AD severity. <b><i>Methods:</i></b> We assessed the SCORing Atopic Dermatitis (SCORAD) index, total immunoglobin E levels and peripheral blood eosinophil counts. VA and VD levels were determined with high-performance liquid chromatography. Correlations among variables were investigated with Pearson’s correlation analysis. <b><i>Results:</i></b> The VD and VA levels were significantly lower in children with AD than in normal children (p &lt; 0.001, p = 0.0423). Both VD and VA levels were negatively correlated with SCORAD scores. The SCORAD scores were significantly higher in AD patients with both VDD and VAD (co-deficiency) than in other AD patients. Significant inverse correlations were observed between peripheral blood eosinophil counts and serum VA and VD levels. <b><i>Conclusions:</i></b> VA and VD co-deficiency may exacerbate AD symptoms in children, but the specific mechanism underlying this relationship requires further study. These findings may indicate the need for studies evaluating the use of VD and VA as potential treatments for AD patients.
DOI: 10.6084/m9.figshare.7969535.v1
title: Comprehensive nuclear proteome of <i>Arabidopsis</i> obtained by sequential extraction

description: In eukaryotes, the nucleus plays key roles in fundamental cellular processes, including DNA replication, chromatin maintenance, transcription, and translation. To better understand the functional diversity of nuclei, we developed a method for the comprehensive extraction of the nuclear proteome from <i>Arabidopsis</i>. We used a buffer with a high sucrose concentration to purify nuclei and then conducted solubility-based fractionation to increase proteome coverage. We identified 1539 proteins and two novel nuclear envelope (NE) proteins in the nuclear fraction of <i>Arabidopsis</i> cultured cells. The localization of 25 proteins was determined by GFP fusion analyses; 23 of these proteins were localized either in the nucleus or the NE-associated endoplasmic reticulum. This result was indicative of the high quality of the proteome. These findings will be useful for clarifying novel nuclear functions in plants.
DOI: 10.6084/m9.figshare.7969628.v1
title: Supplementary Material for: Comorbidity of Vitamin A and Vitamin D Deficiency Exacerbates the Severity of Atopic Dermatitis in Children

description: <b><i>Background:</i></b> Several studies have suggested that vitamin D (VD) deficiency (VDD) is associated with atopic dermatitis (AD). However, little is known about the relationship between AD and vitamin A (VA). The interaction between VA and VD on AD requires further study. <b><i>Objective:</i></b> We detected serum levels of VA and VD in children with AD to explore how VA deficiency (VAD) and VDD affect AD severity. <b><i>Methods:</i></b> We assessed the SCORing Atopic Dermatitis (SCORAD) index, total immunoglobin E levels and peripheral blood eosinophil counts. VA and VD levels were determined with high-performance liquid chromatography. Correlations among variables were investigated with Pearson’s correlation analysis. <b><i>Results:</i></b> The VD and VA levels were significantly lower in children with AD than in normal children (p &lt; 0.001, p = 0.0423). Both VD and VA levels were negatively correlated with SCORAD scores. The SCORAD scores were significantly higher in AD patients with both VDD and VAD (co-deficiency) than in other AD patients. Significant inverse correlations were observed between peripheral blood eosinophil counts and serum VA and VD levels. <b><i>Conclusions:</i></b> VA and VD co-deficiency may exacerbate AD symptoms in children, but the specific mechanism underlying this relationship requires further study. These findings may indicate the need for studies evaluating the use of VD and VA as potential treatments for AD patients.
DOI: 10.6084/m9.figshare.7969415
title: An overlooked invader? Ecological niche, invasion success and range dynamics of the Alexandrine parakeet in the invaded range

description: GIS file with native and invasive range occurrences of Psittacula eupatria<br>https://link.springer.com/article/10.1007/s10530-015-1032-y
DOI: 10.6084/m9.figshare.7969370
title: gVCF_HG02232

description: 1000 Genomes gVCF mapped to hs37d5 for HG02232. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.12876508.v1
title: Additional file of Reliability analysis of the Ahringer Caenorhabditis elegans RNAi feeding library: a guide for genome-wide screens

description: Additional file of Reliability analysis of the Ahringer Caenorhabditis elegans RNAi feeding library: a guide for genome-wide screens
DOI: 10.6084/m9.figshare.7969655.v3
title: PyMOL script for calculating nucleosome-binding factor clash scores

description: PyMOL v.2 and newer script (scanDamage.py) that was used to calculate the clash scores between UV-DDB and nucleosome atomic coordinate models as presented in the article:<br>"DNA damage detection in nucleosomes involves DNA register shifting" <br><br>Matsumoto, Cavadini, Bunker et al., Nature, 2019 <br><br><br><br>
DOI: 10.6084/m9.figshare.7969370.v1
title: gVCF_HG02232

description: 1000 Genomes gVCF mapped to hs37d5 for HG02232. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.1285/i22390359v36p7
title: Verbatim vs. adapted subtitling and beyond. An empirical study with deaf, hard-of-hearing and hearing children

description: This study tests two different existing approaches to Subtitling for the Deaf and the Hard-of-Hearing (SDHH) on deaf, hard-of-hearing and hearing primary-school children in Italy: verbatim subtitles aimed at accuracy (SKY style); and adapted subtitles aimed at usability (RAI style). To this aim, three short, self-contained cartoons were intralingually subtitled (Italian into Italian). The videos were then shown to 35 hearing children and 5 DHH children. The subjects were administered three questionnaires: one collected background data, one measured perception and one measured reception. The data showed that verbatim subtitles not only were the preferred approach by each group of children, but they also facilitated understanding more than adapted subtitles. We also found that SDHH for children did not interfere with comprehension of images in the video, and that adapted subtitles seemed to favour understanding of images more than verbatim ones. Furthermore, analysis of the data collected provided food for thought regarding speaker identification, legibility, readability, text comprehension, and ways to express diegetic sounds, along with a new theoretical framework for the production of SDHH.
DOI: 10.6084/m9.figshare.12876574.v6
title: Additional file of Interactions of a pesticide/heavy metal mixture in marine bivalves: a transcriptomic assessment

description: Additional file of Interactions of a pesticide/heavy metal mixture in marine bivalves: a transcriptomic assessment
DOI: 10.6084/m9.figshare.12876553.v1
title: Additional file 3 of Interactions of a pesticide/heavy metal mixture in marine bivalves: a transcriptomic assessment

description: Additional file 3:GO term over-representation analysis. (XLS 40 KB)
DOI: 10.6084/m9.figshare.12876574.v5
title: Additional file of Interactions of a pesticide/heavy metal mixture in marine bivalves: a transcriptomic assessment

description: Additional file of Interactions of a pesticide/heavy metal mixture in marine bivalves: a transcriptomic assessment
DOI: 10.6084/m9.figshare.12876553
title: Additional file 3 of Interactions of a pesticide/heavy metal mixture in marine bivalves: a transcriptomic assessment

description: Additional file 3:GO term over-representation analysis. (XLS 40 KB)
DOI: 10.6084/m9.figshare.12876556.v1
title: Additional file 4 of Interactions of a pesticide/heavy metal mixture in marine bivalves: a transcriptomic assessment

description: Additional file 4:Supplementary file 3. Additional information to Figure 6. GO terms used to generate multi level pie charts shown in Figure 6. (XLS 22 KB)
DOI: 10.6084/m9.figshare.12876556
title: Additional file 4 of Interactions of a pesticide/heavy metal mixture in marine bivalves: a transcriptomic assessment

description: Additional file 4:Supplementary file 3. Additional information to Figure 6. GO terms used to generate multi level pie charts shown in Figure 6. (XLS 22 KB)
DOI: 10.1285/i22390359v36p31
title: The discourse of historiography in CLIL history textbooks

description: CLIL is the acronym coined by professors David Marsh and Anne Maljers and it stands for Content and Language Integrated Learning. It describes a well-known and widespread methodology in Europe and in the Italian school system which was officially recognised in 1994. The current Italian school legislation has adopted it both to increase SL practice and to promote learner-centred approaches and teaching innovation. The Italian publishing industry has started to dedicate much attention to the development of ready-made supports for high school teachers and fix 'canonical' topics. Following the recent analyses of authorial voice in the academic discourse of historiography (Bondi 2007; 2009; 2012; 2014; 2017) and the applications of corpus linguistics/stylistics and appraisal theory to different textual typologies (White 2002; Martin and White 2005), this article aims at exploring the seemingly marginal textuality produced for CLIL history teaching. It constitutes an attempt at tracing stances of authorial voice in a corpus of 23 titles representing the totality of CLIL history textbooks adopted in the fifth year of Italian Licei and Istituti Tecnici throughout Italy. This corpus will be analysed with the aid of databases belonging to the most important and 'CLIL-involved' Italian publishers of schoolbooks and CLIL booklets (among others, Mondadori Scuola, Einaudi Scuola, Laterza Scolastica and more). The discourse analysis conducted on the texts will attempt at highlighting how the authors' different approaches to and viewpoints on contemporary history are conveyed linguistically in English, which in most cases is not their native language.
DOI: 10.1285/i22390359v36p43
title: How to explain diachronic variation of politeness. The example of German pronouns of address

description: This contribution looks at diachronic developments in the forms and uses of German address pronouns and treats them as one example of politeness change. The discussion shows that the historical analysis of the pronouns is very precise in the description of their developments, but fails to explain how and why address forms change. In order to facilitate an explanatory approach, the concept of politeness needs to be addressed too. The article proposes a contemporary concept of politeness as relational work that can contribute to accounting for these diachronic processes, and that can also be used to explain politeness change as an example of an invisible-hand process.
DOI: 10.6084/m9.figshare.12876631.v9
title: Additional file of Expression variability of co-regulated genes differentiates Saccharomyces cerevisiae strains

description: Additional file of Expression variability of co-regulated genes differentiates Saccharomyces cerevisiae strains
DOI: 10.6084/m9.figshare.12876634
title: Additional file 1 of A high-density transcript linkage map with 1,845 expressed genes positioned by microarray-based Single Feature Polymorphisms (SFP) in Eucalyptus

description: Additional file 1:Full map with 1,845 SFPs and 208 microsatellites. Ordered linkage mapping data for the full map built with JoinMap at relaxed ordering threshold involving 1,845 SFPs and 208 microsatellites. Information includes the Unigene ID in the original EST database, Probe_ID, SFP Marker ID, Linkage group, Position in centiMorgan, Probe_sequence, Unigene_sequence, number of probes designed in the probe set, Best BLAST hit against nr, Identity and e-value, annotation description generated using Blast2GO, number of blast hits with e-value equal or greater than -20, mean similarity for these hits, number of GO terms mapped, GOs that were annotated to the gene and enzyme codes generated by the annotation. (XLS 1 MB)
DOI: 10.6084/m9.figshare.12876634.v1
title: Additional file 1 of A high-density transcript linkage map with 1,845 expressed genes positioned by microarray-based Single Feature Polymorphisms (SFP) in Eucalyptus

description: Additional file 1:Full map with 1,845 SFPs and 208 microsatellites. Ordered linkage mapping data for the full map built with JoinMap at relaxed ordering threshold involving 1,845 SFPs and 208 microsatellites. Information includes the Unigene ID in the original EST database, Probe_ID, SFP Marker ID, Linkage group, Position in centiMorgan, Probe_sequence, Unigene_sequence, number of probes designed in the probe set, Best BLAST hit against nr, Identity and e-value, annotation description generated using Blast2GO, number of blast hits with e-value equal or greater than -20, mean similarity for these hits, number of GO terms mapped, GOs that were annotated to the gene and enzyme codes generated by the annotation. (XLS 1 MB)
DOI: 10.6084/m9.figshare.12876637
title: Additional file 2 of A high-density transcript linkage map with 1,845 expressed genes positioned by microarray-based Single Feature Polymorphisms (SFP) in Eucalyptus

description: Additional file 2:Framework map with 884 SFPs and 180 microsatellites. Ordered linkage mapping data for the framework map built with JoinMap at high likelhood support for ordering involving 884 SFPs and 180 microsatellites. Information includes the Unigene ID in the original EST database, Probe_ID, SFP Marker ID, Linkage group, Position in centiMorgan, Probe_sequence, Unigene_sequence, number of probes designed in the probe set, Best BLAST hit against nr, Identity and e-value, annotation description generated using Blast2GO, number of blast hits with e-value equal or greater than -20, mean similarity for these hits, number of GO terms mapped, GOs that were annotated to the gene and enzyme codes generated by the annotation. (XLS 628 KB)
DOI: 10.6084/m9.figshare.12876637.v1
title: Additional file 2 of A high-density transcript linkage map with 1,845 expressed genes positioned by microarray-based Single Feature Polymorphisms (SFP) in Eucalyptus

description: Additional file 2:Framework map with 884 SFPs and 180 microsatellites. Ordered linkage mapping data for the framework map built with JoinMap at high likelhood support for ordering involving 884 SFPs and 180 microsatellites. Information includes the Unigene ID in the original EST database, Probe_ID, SFP Marker ID, Linkage group, Position in centiMorgan, Probe_sequence, Unigene_sequence, number of probes designed in the probe set, Best BLAST hit against nr, Identity and e-value, annotation description generated using Blast2GO, number of blast hits with e-value equal or greater than -20, mean similarity for these hits, number of GO terms mapped, GOs that were annotated to the gene and enzyme codes generated by the annotation. (XLS 628 KB)
DOI: 10.6084/m9.figshare.12876640.v1
title: Additional file 3 of A high-density transcript linkage map with 1,845 expressed genes positioned by microarray-based Single Feature Polymorphisms (SFP) in Eucalyptus

description: Additional file 3:Eucalyptus SFP screening 103k-probe array. List of the 103,000 25-mer oligonucleotide probes designed from 20,726 Eucalyptus unigenes and used in the SFP-discovery microarray. (TXT 11 MB)
DOI: 10.6084/m9.figshare.12876652.v1
title: Additional file of A high-density transcript linkage map with 1,845 expressed genes positioned by microarray-based Single Feature Polymorphisms (SFP) in Eucalyptus

description: Additional file of A high-density transcript linkage map with 1,845 expressed genes positioned by microarray-based Single Feature Polymorphisms (SFP) in Eucalyptus
DOI: 10.6084/m9.figshare.12876652.v2
title: Additional file of A high-density transcript linkage map with 1,845 expressed genes positioned by microarray-based Single Feature Polymorphisms (SFP) in Eucalyptus

description: Additional file of A high-density transcript linkage map with 1,845 expressed genes positioned by microarray-based Single Feature Polymorphisms (SFP) in Eucalyptus
DOI: 10.6084/m9.figshare.12876652.v3
title: Additional file of A high-density transcript linkage map with 1,845 expressed genes positioned by microarray-based Single Feature Polymorphisms (SFP) in Eucalyptus

description: Additional file of A high-density transcript linkage map with 1,845 expressed genes positioned by microarray-based Single Feature Polymorphisms (SFP) in Eucalyptus
DOI: 10.6084/m9.figshare.12876640
title: Additional file 3 of A high-density transcript linkage map with 1,845 expressed genes positioned by microarray-based Single Feature Polymorphisms (SFP) in Eucalyptus

description: Additional file 3:Eucalyptus SFP screening 103k-probe array. List of the 103,000 25-mer oligonucleotide probes designed from 20,726 Eucalyptus unigenes and used in the SFP-discovery microarray. (TXT 11 MB)
DOI: 10.6084/m9.figshare.7968053
title: Additional file 4: of Implementation of genotype-guided dosing of warfarin with point-of-care genetic testing in three UK clinics: a matched cohort study

description: Study data. (XLSX 66 kb)
DOI: 10.6084/m9.figshare.7968053.v1
title: Additional file 4: of Implementation of genotype-guided dosing of warfarin with point-of-care genetic testing in three UK clinics: a matched cohort study

description: Study data. (XLSX 66 kb)