cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.5952304
title: Pressure and Zeolites

description: Poster presented at the 2018 Twitter Poster Conference by RSC, 6th march 2018<br>Research described in the poster can be found in the following papers free to download<br>Fluorenone at high pressure:10.3390/cryst8020079<br><br>Water-ethanol at high pressure:http://bit.ly/2De8HQq<br>Official publisher version http://onlinelibrary.wiley.com/doi/10.1002/anie.201700219/abstract
DOI: 10.6084/m9.figshare.5952304.v1
title: Pressure and Zeolites

description: Poster presented at the 2018 Twitter Poster Conference by RSC, 6th march 2018<br>Research described in the poster can be found in the following papers free to download<br>Fluorenone at high pressure:10.3390/cryst8020079<br><br>Water-ethanol at high pressure:http://bit.ly/2De8HQq<br>Official publisher version http://onlinelibrary.wiley.com/doi/10.1002/anie.201700219/abstract
DOI: 10.6084/m9.figshare.5952217
title: Supplementary Material for: A STAT6 Inhibitor AS1517499 Reduces Preventive Effects of Apoptotic Cell Instillation on Bleomycin-Induced Lung Fibrosis by Suppressing PPARγ

description: <b><i>Background/Aims:</i></b> The signal transducer and activator of transcription 6 (STAT6) transcription factor mediates PPARγ-regulated gene expression in macrophages. However, it remains largely unknown how proximal membrane signaling events initiated by apoptotic cell recognition upregulate PPARγ expression and activate the lung homeostatic program. <b><i>Methods:</i></b> The STAT6 inhibitor AS1517499 was used to determine the role of STAT6 in mediating PPARγ activity, anti-inflammatory effects, and anti-fibrotic effects induced by apoptotic cell instillation after bleomycin treatment into C57BL/6 mice. Bronchoalveolar lavage fluid, alveolar macrophages and lungs were harvested at days 2, 7, and 14 and then analyzed by real-time PCR, immunoblotting, ELISA, immunocytochemistry and immunohistochemistry assays. <b><i>Results:</i></b> Our data demonstrate that apoptotic cell instillation after bleomycin results in prolonged enhancement of STAT6 phosphorylation in alveolar macrophages and lung. Co-administration of the STAT6 inhibitor, AS1517499, reversed the enhanced PPARγ expression and activity induced by apoptotic cell instillation after bleomycin treatment. By reducing the expression of PPARγ target genes, including CD36, macrophage mannose receptor, and arginase 1, AS1517499 inhibited efferocytosis and restored pro-inflammatory cytokine expression, neutrophil recruitment, protein levels, hydroxyproline content, and expression of fibrosis markers, including type 1 collagen α2, fibronectin, and α-smooth muscle actin. STAT6 inhibition reversed the expression profile of hepatocyte growth factor and interleukin-10. <b><i>Conclusion:</i></b> These results indicate that prolonged STAT6 activation following one-time apoptotic cell instillation facilitates continuous PPARγ activation, resulting in the resolution of bleomycin-induced lung inflammation and fibrosis.
DOI: 10.6084/m9.figshare.5952217.v1
title: Supplementary Material for: A STAT6 Inhibitor AS1517499 Reduces Preventive Effects of Apoptotic Cell Instillation on Bleomycin-Induced Lung Fibrosis by Suppressing PPARγ

description: <b><i>Background/Aims:</i></b> The signal transducer and activator of transcription 6 (STAT6) transcription factor mediates PPARγ-regulated gene expression in macrophages. However, it remains largely unknown how proximal membrane signaling events initiated by apoptotic cell recognition upregulate PPARγ expression and activate the lung homeostatic program. <b><i>Methods:</i></b> The STAT6 inhibitor AS1517499 was used to determine the role of STAT6 in mediating PPARγ activity, anti-inflammatory effects, and anti-fibrotic effects induced by apoptotic cell instillation after bleomycin treatment into C57BL/6 mice. Bronchoalveolar lavage fluid, alveolar macrophages and lungs were harvested at days 2, 7, and 14 and then analyzed by real-time PCR, immunoblotting, ELISA, immunocytochemistry and immunohistochemistry assays. <b><i>Results:</i></b> Our data demonstrate that apoptotic cell instillation after bleomycin results in prolonged enhancement of STAT6 phosphorylation in alveolar macrophages and lung. Co-administration of the STAT6 inhibitor, AS1517499, reversed the enhanced PPARγ expression and activity induced by apoptotic cell instillation after bleomycin treatment. By reducing the expression of PPARγ target genes, including CD36, macrophage mannose receptor, and arginase 1, AS1517499 inhibited efferocytosis and restored pro-inflammatory cytokine expression, neutrophil recruitment, protein levels, hydroxyproline content, and expression of fibrosis markers, including type 1 collagen α2, fibronectin, and α-smooth muscle actin. STAT6 inhibition reversed the expression profile of hepatocyte growth factor and interleukin-10. <b><i>Conclusion:</i></b> These results indicate that prolonged STAT6 activation following one-time apoptotic cell instillation facilitates continuous PPARγ activation, resulting in the resolution of bleomycin-induced lung inflammation and fibrosis.
DOI: 10.17633/rd.brunel.5952178
title: Refinement of Mg alloys crystal structure via Nb-based heterogeneous substrates for improved performances Dataset

description: Microstructures, Grain size measurements & Tensile properties
DOI: 10.17633/rd.brunel.5952178.v1
title: Refinement of Mg alloys crystal structure via Nb-based heterogeneous substrates for improved performances Dataset

description: Microstructures, Grain size measurements & Tensile properties
DOI: 10.6084/m9.figshare.5952175
title: Supplementary Material for: Real-World Treatment Patterns, Survival, and Prediction of CNS Progression in ALK-Positive Non-Small-Cell Lung Cancer Patients Treated with First-Line Crizotinib in Latin America Oncology Practices

description: <b><i>Objective:</i></b> This study describes the real-world characteristics, treatment sequencing, and outcomes among Hispanic patients with locally advanced/metastatic ALK-positive non-small-cell lung cancer (NSCLC) treated with crizotinib. <b><i>Methods:</i></b> A retrospective patient review was conducted for several centers in Latin America. Clinicians identified ALK-positive NSCLC patients who received crizotinib and reported their clinical characteristics, treatments, and survival. Overall survival and progression-free survival (PFS) were described. A Random Forest Tree (RFT) model was constructed to predict brain progression. <b><i>Results:</i></b> A total of 73 patients were included; median age at diagnosis was 58 years, 60.3% were female, and 93.2% had adenocarcinoma. Eighty-nine percent of patients were never smokers/former smokers, 71.1% had ≥2 sites of metastasis, and 20.5% had brain metastases at diagnosis. The median PFS on first-line crizotinib was 7.07 months (95% CI 3.77–12.37) and the overall response rate was 52%. Of those who discontinued crizotinib, 55.9% progressed in the central nervous system (CNS). The RFT model reached a sensitivity of 100% and a specificity of 88% for prediction of CNS progression. <b><i>Conclusions:</i></b> The overall response rate and the PFS observed in Hispanic patients with ALK-positive NSCLC treated with first-line crizotinib were similar to those in previous reports. An RFT model is helpful in predicting CNS progression and can help clinicians tailor treatments in a resource-limited practice.
DOI: 10.6084/m9.figshare.5952175.v1
title: Supplementary Material for: Real-World Treatment Patterns, Survival, and Prediction of CNS Progression in ALK-Positive Non-Small-Cell Lung Cancer Patients Treated with First-Line Crizotinib in Latin America Oncology Practices

description: <b><i>Objective:</i></b> This study describes the real-world characteristics, treatment sequencing, and outcomes among Hispanic patients with locally advanced/metastatic ALK-positive non-small-cell lung cancer (NSCLC) treated with crizotinib. <b><i>Methods:</i></b> A retrospective patient review was conducted for several centers in Latin America. Clinicians identified ALK-positive NSCLC patients who received crizotinib and reported their clinical characteristics, treatments, and survival. Overall survival and progression-free survival (PFS) were described. A Random Forest Tree (RFT) model was constructed to predict brain progression. <b><i>Results:</i></b> A total of 73 patients were included; median age at diagnosis was 58 years, 60.3% were female, and 93.2% had adenocarcinoma. Eighty-nine percent of patients were never smokers/former smokers, 71.1% had ≥2 sites of metastasis, and 20.5% had brain metastases at diagnosis. The median PFS on first-line crizotinib was 7.07 months (95% CI 3.77–12.37) and the overall response rate was 52%. Of those who discontinued crizotinib, 55.9% progressed in the central nervous system (CNS). The RFT model reached a sensitivity of 100% and a specificity of 88% for prediction of CNS progression. <b><i>Conclusions:</i></b> The overall response rate and the PFS observed in Hispanic patients with ALK-positive NSCLC treated with first-line crizotinib were similar to those in previous reports. An RFT model is helpful in predicting CNS progression and can help clinicians tailor treatments in a resource-limited practice.
DOI: 10.6084/m9.figshare.5952145
title: Supplementary Material for: Immune Gene Expression Profile in Hepatocellular Carcinoma and Surrounding Tissue Predicts Time to Tumor Recurrence

description: <b><i>Background:</i></b> The antitumor immune response may play a major role in the clinical outcome of hepatocellular carcinoma (HCC). We characterized the liver immune microenvironment by direct hybridization of RNA extracted from HCC and nontumorous tissues. <b><i>Methods:</i></b> RNA was extracted from frozen liver tissue samples of HCC (T; <i>n</i> = 30) and nontumorous tissues (NT; <i>n</i> = 33) obtained from 38 patients. Matched samples were available for 25 patients. The immune gene expression profile was analyzed with the nCounter GX Human Immunology v2 system (NanoString Technologies), which detects the expression levels of 579 immune response-related genes simultaneously. <b><i>Results:</i></b> Since the immune gene expression profile of T and NT tissues was significantly different, the prognostic relevance of the liver immune microenvironment was evaluated in the T and NT samples separately. Unsupervised clustering detected two main clusters of immune gene expression both in T and in NT liver samples. In both cases, the expression clusters identified groups of patients with a significantly different median time to HCC recurrence (TTR) but similar overall survival. Based on T tissue, two groups with median TTR of 19 and 127 months, respectively, were detected (<i>p</i> &lt; 0.005). Expression of genes related to T-cell activation was associated with longer TTR. The analysis of NT tissue discriminated subsets of patients with median TTR of 22 and 68 months (<i>p</i> &lt; 0.05). In contrast to T tissue, a predominant inflammatory immune environment was associated with shorter TTR. <b><i>Conclusions:</i></b> Immune gene expression profiles predictive of TTR could be identified both in HCC and in adjacent cirrhotic tissues. Longer TTR was associated with overexpression in T tissue and downregulation in NT tissue of the immune response and of inflammation-related genes.
DOI: 10.17028/rd.lboro.5952133
title: Dataset for "The heat transfer characteristics of a mesoscale continuous oscillatory flow crystalliser with smooth periodic constrictions"

description: The heat transfer performance of a 5 mm internal diameter (I.D.) mesoscale continuous oscillatory flow crystalliser with smooth periodic constrictions (herein called SPC meso-tube) is herein reported for the first time for both steady flow and unsteady oscillatory flow conditions. Experimental values of the tube-side Nusselt number, <i>Nu<sub>t</sub></i>, accompanied by an estimability analysis, emphasised the key role played by smooth constrictions and bulk flow velocity in controlling tube-side heat transfer in the SPC meso-tube, while revealing a weaker influence of oscillatory flow on heat transfer enhancement in the tube. Although the presence of smooth constrictions provided an increased surface area to volume ratio, and re-circulation zones which promoted heat transfer rates, a maximum 1.7-fold heat transfer augmentation was obtained when fluid oscillations were combined with smooth constrictions. The behaviour of the SPC meso-tube was such that increasing the net flow Reynolds number, <i>Re<sub>o</sub></i>, from 11 up to 54 with the combination of smooth constrictions and oscillatory flow resulted in the attainment of higher rates of heat transfer up to a maximum of 3.09. The Strouhal number, <i>St</i>, was also found to have a more significant effect on the heat transfer performance than oscillatory frequency. An empirical correlation was for the first time developed to describe the heat transfer characteristics of the SPC meso-tube, and predict based on experimental data for the range of net flow and oscillatory flow conditions investigated. A parameter estimability approach was also implemented to enhance the prediction capability of the correlation. The approach was based on a sequential orthogonalisation, thanks to which the most influential factors affecting the tube-side heat transfer were identified given the available experimental data. Overall, the results accentuate the efficient heat transfer capabilities of the SPC meso-tube in low laminar flow regimes, and its suitability for performing cooling crystallisations where tight temperature control of supersaturation is essential.
DOI: 10.17028/rd.lboro.5952133.v1
title: Dataset for "The heat transfer characteristics of a mesoscale continuous oscillatory flow crystalliser with smooth periodic constrictions"

description: The heat transfer performance of a 5 mm internal diameter (I.D.) mesoscale continuous oscillatory flow crystalliser with smooth periodic constrictions (herein called SPC meso-tube) is herein reported for the first time for both steady flow and unsteady oscillatory flow conditions. Experimental values of the tube-side Nusselt number, <i>Nu<sub>t</sub></i>, accompanied by an estimability analysis, emphasised the key role played by smooth constrictions and bulk flow velocity in controlling tube-side heat transfer in the SPC meso-tube, while revealing a weaker influence of oscillatory flow on heat transfer enhancement in the tube. Although the presence of smooth constrictions provided an increased surface area to volume ratio, and re-circulation zones which promoted heat transfer rates, a maximum 1.7-fold heat transfer augmentation was obtained when fluid oscillations were combined with smooth constrictions. The behaviour of the SPC meso-tube was such that increasing the net flow Reynolds number, <i>Re<sub>o</sub></i>, from 11 up to 54 with the combination of smooth constrictions and oscillatory flow resulted in the attainment of higher rates of heat transfer up to a maximum of 3.09. The Strouhal number, <i>St</i>, was also found to have a more significant effect on the heat transfer performance than oscillatory frequency. An empirical correlation was for the first time developed to describe the heat transfer characteristics of the SPC meso-tube, and predict based on experimental data for the range of net flow and oscillatory flow conditions investigated. A parameter estimability approach was also implemented to enhance the prediction capability of the correlation. The approach was based on a sequential orthogonalisation, thanks to which the most influential factors affecting the tube-side heat transfer were identified given the available experimental data. Overall, the results accentuate the efficient heat transfer capabilities of the SPC meso-tube in low laminar flow regimes, and its suitability for performing cooling crystallisations where tight temperature control of supersaturation is essential.
DOI: 10.6084/m9.figshare.5952115
title: Supplementary Material for: Newborn Plasma Glucose Concentration Nadirs by Gestational-Age Group

description: <b><i>Background:</i></b> The glucose concentrations and times to nadir for newborns of all gestational ages when intrapartum glucose-containing solutions are not routinely provided are unknown. <b><i>Objective:</i></b> To characterize and compare patterns of initial glucose concentration nadirs by gestational-age groups. <b><i>Methods:</i></b> A cross-sectional cohort study of 1,366 newborns born in 1998 at the University of Arkansas for Medical Sciences, appropriate for gestational age, nonasphyxiated, nonpolycythemic, and not infants of diabetic mothers, were included. Initial plasma glucose concentrations, before intravenous fluids or feedings, were plotted against time after birth for 4 gestational-age groups (full term [FT], ≥37–42 weeks; late preterm [LPT], ≥34 and &lt; 37 weeks; preterm [PT], ≥28 and &lt; 34 weeks; and extremely low gestational age newborns [ELGAN], 23 and &lt; 28 weeks of gestation). <b><i>Results:</i></b> ELGAN had the earliest nadir at 61 ± 4 min, followed by PT newborns (71 ± 2 min), and then LPT and FT newborns at 92–93 min. The time to nadir for ELGAN and PT newborns was significantly earlier than for FT newborns. Glucose nadir concentrations for ELGAN, PT, and LPT newborns were significantly lower than for FT newborns. LPT newborns’ pattern of glucose paralleled those of FT newborns, with values approximately 5–6 mg/dL lower during the first 3 h. <b><i>Conclusion:</i></b> Plasma glucose nadirs occurred at different times among gestational-age groups during the early postnatal period as follows: ELGAN &lt; PT &lt; LPT ≈ FT. In order to potentially prevent low glucose concentrations at the time of the nadir, exogenous glucose should be provided to all newborns as soon as possible after birth.
DOI: 10.6084/m9.figshare.5952025
title: Precipitation and Temperature from a Regional Climate Model simulation with CCLM for Europe over the period 1645-1999CE

description: This data set provides monthly means of precipitation and temperature data for a regional climate simulation over the European domain. The regional climate model COSCMO-CCLM (https://www.clm-community.eu/) was driven at the boundaries by output from the COSMOS setup of the Earth Model of the MPI in Hamburg (MPI-ESM, compare https://www.mpimet.mpg.de/en/science/projects/archive/millennium/). Jungclaus et al. (2010) describe the MPI-ESM model and the set-up. The CCLM-simulation includes changes in orbital and greenhouse forcings, variations in the TSI, and the effect of land use changes. The data set provides remapped data on a regular 0.5° × 0.5° grid. This simulation spans the period 1645-1999, the data are monthly means. The spatial domain is 10°W to 37.5°E and 30.5° to 69°N. Original data is available from Sebastian Wagner at the Helmholtz Zentrum Geesthacht (sebastian.wagner(at)hzg.de). <br>Referenz for driving data: Jungclaus, J. H., Lorenz, S. J., Timmreck, C., Reick, C. H., Brovkin, V., Six, K., Segschneider, J., Giorgetta, M. A., Crowley, T. J., Pongratz, J., Krivova, N. A., Vieira, L. E., Solanki, S. K., Klocke, D., Botzet, M., Esch, M., Gayler, V., Haak, H., Raddatz, T. J., Roeckner, E., Schnur, R., Widmann, H., Claussen, M., Stevens, B., and Marotzke, J.: Climate and carbon-cycle variability over the last millennium, Clim. Past, 6, 723-737, https://doi.org/10.5194/cp-6-723-2010, 2010<br>
DOI: 10.6084/m9.figshare.5952025.v1
title: Precipitation and Temperature from a Regional Climate Model simulation with CCLM for Europe over the period 1645-1999CE

description: This data set provides monthly means of precipitation and temperature data for a regional climate simulation over the European domain. The regional climate model COSCMO-CCLM (https://www.clm-community.eu/) was driven at the boundaries by output from the COSMOS setup of the Earth Model of the MPI in Hamburg (MPI-ESM, compare https://www.mpimet.mpg.de/en/science/projects/archive/millennium/). Jungclaus et al. (2010) describe the MPI-ESM model and the set-up. The CCLM-simulation includes changes in orbital and greenhouse forcings, variations in the TSI, and the effect of land use changes. The data set provides remapped data on a regular 0.5° × 0.5° grid. This simulation spans the period 1645-1999, the data are monthly means. The spatial domain is 10°W to 37.5°E and 30.5° to 69°N. Original data is available from Sebastian Wagner at the Helmholtz Zentrum Geesthacht (sebastian.wagner(at)hzg.de). <br>Referenz for driving data: Jungclaus, J. H., Lorenz, S. J., Timmreck, C., Reick, C. H., Brovkin, V., Six, K., Segschneider, J., Giorgetta, M. A., Crowley, T. J., Pongratz, J., Krivova, N. A., Vieira, L. E., Solanki, S. K., Klocke, D., Botzet, M., Esch, M., Gayler, V., Haak, H., Raddatz, T. J., Roeckner, E., Schnur, R., Widmann, H., Claussen, M., Stevens, B., and Marotzke, J.: Climate and carbon-cycle variability over the last millennium, Clim. Past, 6, 723-737, https://doi.org/10.5194/cp-6-723-2010, 2010<br>
DOI: 10.6084/m9.figshare.5952004
title: Top 1,000 Brazilian companies, by net revenue

description: Dataset for the paper "Granularity of the top 1,000 Brazilian companies."
DOI: 10.6084/m9.figshare.5952004.v1
title: Untitled Item

description: Dataset for the paper "Granularity of the top 1,000 Brazilian companies."
DOI: 10.6084/m9.figshare.5951968
title: Supplementary Material for: Place of Residence and Cognitive Function among the Adult Population in India

description: <b><i>Background:</i></b> The place of residence has been linked to cognitive function among adults in developed countries. This study examined how urban and rural residence was associated with cognitive function among adults in India. <b><i>Methods:</i></b> The World Health Organization Study on Global AGEing and Adult Health data was used to examine cognition among 6,244 community-residing adults age 50+ in 6 states in India. Residential status was categorized as urban, rural, urban-to-urban, rural-to-urban, rural-to-rural, and urban-to-rural. Cognition was assessed by immediate and delayed recall tests, digit span test, and verbal fluency test. Multilevel models were used to account for state-level differences and adjusted for individual-level sociodemographic, psychosocial, and health-related factors. <b><i>Results:</i></b> Urban residents and urban-to-urban migrants had the highest levels of cognition, whereas rural residents and those who migrated to (or within) rural areas had the lowest cognition. The differences largely persisted after adjustment for multiple covariates; however, rural-to-urban migrants had no difference in cognition from urban residents once socioeconomic factors were taken into account. <b><i>Conclusion:</i></b> Cognition among adults in India differed significantly according to their current and past place of residence. Socioeconomic factors played an important role in the cognitive function of adults in urban areas.
DOI: 10.6084/m9.figshare.5951965
title: Files for reanalysis of Kersken et al. (2018)

description: Alignments, partition and secondary structure information, and phylogenetic tree of "Progress in glass sponge phylogenetics: a comment on Kersken et al. (2018)" [Hydrobiologia in press].<br>
DOI: 10.6084/m9.figshare.5951965.v1
title: Files for reanalysis of Kersken et al. (2018)

description: Alignments, partition and secondary structure information, and phylogenetic tree of "Progress in glass sponge phylogenetics: a comment on Kersken et al. (2018)" [Hydrobiologia in press].<br>