cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.5517/ccy8x03
title: CCDC 872495: Experimental Crystal Structure Determination

description: Related Article: R.Al-Salahi, M.Al-Omar, H.El-Subbagh, M.Hemamalini, H.-K.Fun|2012|Acta Crystallogr.,Sect.E:Struct.Rep.Online|68|o717|doi:10.1107/S1600536812006009
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccy8x14
title: CCDC 872496: Experimental Crystal Structure Determination

description: Related Article: H.J.Beack, S.M.Yoo, J.E.Kim, W.Sim, J.Y.Lee|2012|Acta Crystallogr.,Sect.E:Struct.Rep.Online|68|o720|doi:10.1107/S160053681200565X
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccy8x25
title: CCDC 872497: Experimental Crystal Structure Determination

description: Related Article: Hua-Wen Wen, Li-Xia Fan, Li Liu, Ao Li, Qi Fang|2012|Acta Crystallogr.,Sect.E:Struct.Rep.Online|68|o721|doi:10.1107/S1600536812005703
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccy8x36
title: CCDC 872498: Experimental Crystal Structure Determination

description: Related Article: Xue-Jun He, Jiang-Kai Qiu, Yu-Chi Jia, De-Cai Wang, Ping-Kai Ou-Yang|2012|Acta Crystallogr.,Sect.E:Struct.Rep.Online|68|o722|doi:10.1107/S1600536812002759
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccy8x47
title: CCDC 872499: Experimental Crystal Structure Determination

description: Related Article: V.Z.Rodrigues, B.T.Gowda, V.Vrabel, J.Kozisek|2012|Acta Crystallogr.,Sect.E:Struct.Rep.Online|68|o723|doi:10.1107/S1600536812005739
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.6084/m9.figshare.30407113
title: Supplementary Material for: Validity and Reliability of the Italian Adaptation of GOS.SP.ASS. ’98 Protocol for Assessing Speech in Children with Cleft Lip and Palate

description: Introduction: The study investigates the psychometric properties of the GOS.SP.ASS. '98 – Italian version protocol for assessing speech in individuals with clefts. Intra- and inter-rater reliability, concurrent validity, criterion validity, and responsiveness of the protocol were examined across specific parameters: hypernasality, hyponasality, nasal emission, turbulence, intelligibility, acceptability, and consonant production.
Methods: The retrospective cross-sectional observational study involved 45 Italian-speaking children with repaired cleft lip and/or palate, evaluated at ages 3 (n=15), 5 (n=15), or 10 years (n=15). For criterion validity, participants were divided into sub-groups based on the severity of speech impairment. For responsiveness, a subset of 18 children who underwent pre- and post-operative assessments following velo-pharyngoplasty was identified.
Results: Results showed good to very good reliability for most parameters, including hypernasality, nasal emission, intelligibility, and acceptability. However, hyponasality and nasal turbulence exhibited lower reliability due to limited variability. Intelligibility scores correlated significantly with the percentage of phonemes correct and percentage of consonants correct, demonstrating concurrent validity. Criterion validity was supported by the GOS.SP.ASS. '98 Italian version protocol's ability to distinguish between groups with different speech impairment levels based on intelligibility scores and articulatory accuracy. Post-surgical assessments revealed significant improvements in hypernasality and nasal emission, underscoring the protocol's responsiveness.
Conclusion: The findings suggest that the GOS.SP.ASS. '98 – Italian version is a reliable and valid tool for the perceptual evaluation of speech outcomes in cleft palate patients, supporting its clinical use to assess speech characteristics and detect changes pre- and post-surgery.
DOI: 10.6084/m9.figshare.30407113.v1
title: Supplementary Material for: Validity and Reliability of the Italian Adaptation of GOS.SP.ASS. ’98 Protocol for Assessing Speech in Children with Cleft Lip and Palate

description: Introduction: The study investigates the psychometric properties of the GOS.SP.ASS. '98 – Italian version protocol for assessing speech in individuals with clefts. Intra- and inter-rater reliability, concurrent validity, criterion validity, and responsiveness of the protocol were examined across specific parameters: hypernasality, hyponasality, nasal emission, turbulence, intelligibility, acceptability, and consonant production.
Methods: The retrospective cross-sectional observational study involved 45 Italian-speaking children with repaired cleft lip and/or palate, evaluated at ages 3 (n=15), 5 (n=15), or 10 years (n=15). For criterion validity, participants were divided into sub-groups based on the severity of speech impairment. For responsiveness, a subset of 18 children who underwent pre- and post-operative assessments following velo-pharyngoplasty was identified.
Results: Results showed good to very good reliability for most parameters, including hypernasality, nasal emission, intelligibility, and acceptability. However, hyponasality and nasal turbulence exhibited lower reliability due to limited variability. Intelligibility scores correlated significantly with the percentage of phonemes correct and percentage of consonants correct, demonstrating concurrent validity. Criterion validity was supported by the GOS.SP.ASS. '98 Italian version protocol's ability to distinguish between groups with different speech impairment levels based on intelligibility scores and articulatory accuracy. Post-surgical assessments revealed significant improvements in hypernasality and nasal emission, underscoring the protocol's responsiveness.
Conclusion: The findings suggest that the GOS.SP.ASS. '98 – Italian version is a reliable and valid tool for the perceptual evaluation of speech outcomes in cleft palate patients, supporting its clinical use to assess speech characteristics and detect changes pre- and post-surgery.
DOI: 10.5517/ccy8x58
title: CCDC 872500: Experimental Crystal Structure Determination

description: Related Article: M.R.Melardi, M.Aghamohamadi, J.Attar Gharamaleki, M.K.Rofouei, B.Notash|2012|Acta Crystallogr.,Sect.E:Struct.Rep.Online|68|o724|doi:10.1107/S1600536812005132
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccy8x69
title: CCDC 872501: Experimental Crystal Structure Determination

description: Related Article: V.Knizhnikov, M.Gorichko, Z.Voitenko|2012|Acta Crystallogr.,Sect.E:Struct.Rep.Online|68|o725|doi:10.1107/S1600536812005636
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccy8x7b
title: CCDC 872502: Experimental Crystal Structure Determination

description: Related Article: Yin-jun Zhang, Dong Wang, Hai-Liang Zhang, Yu-Guang Wang|2012|Acta Crystallogr.,Sect.E:Struct.Rep.Online|68|o726|doi:10.1107/S160053681200596X
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccy8x8c
title: CCDC 872503: Experimental Crystal Structure Determination

description: Related Article: Han Yan, Mi-Hua Hao|2012|Acta Crystallogr.,Sect.E:Struct.Rep.Online|68|o727|doi:10.1107/S1600536812005570
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccy8x9d
title: CCDC 872504: Experimental Crystal Structure Determination

description: Related Article: A.M.Isloor, U.S.Rai, P.Shetty, T.Gerber, E.Hosten, R.Betz|2012|Acta Crystallogr.,Sect.E:Struct.Rep.Online|68|o728|doi:10.1107/S1600536812005995
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccy8xbf
title: CCDC 872505: Experimental Crystal Structure Determination

description: Related Article: N.R.Penthala, S.Parkin, P.A.Crooks|2012|Acta Crystallogr.,Sect.E:Struct.Rep.Online|68|o729|doi:10.1107/S1600536812005855
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.6084/m9.figshare.30407116
title: Supplementary Material for: Ovotesticular Disorder of Sex Development with 46,XX/47,XXY Mosaicism: Challenges in Diagnosis, Gender Assignment, Gonadal Preservation, and Long-Term Oncologic Surveillance: A Case Report

description: Introduction
Ovotesticular disorder of sex development (DSD) is a rare condition, most commonly associated with a 46,XX karyotype. Mosaic karyotypes such as 46,XX/47,XXY are extremely uncommon and pose unique diagnostic and management challenges, particularly regarding gender assignment, gonadal preservation, and long-term surveillance.
Case Presentation
We report a patient with 46,XX/47,XXY mosaicism who presented at birth with ambiguous genitalia. Imaging and histology revealed a right testis, a left ovary, and both Müllerian and Wolffian structures. Following multidisciplinary evaluation and parental counseling, the child was raised as male and underwent staged masculinizing genitoplasty, including hysterectomy, vaginectomy, and hypospadias repair. At age 11, rising estradiol levels and gynecomastia led to the discovery of hormonally active ovarian tissue within the right gonad. Gonad-sparing reoperation was performed to remove the ovarian component while preserving testicular tissue. Histology confirmed the presence of follicles and intact seminiferous tubules. Despite favorable pathology, elevated gonadotropins indicated primary gonadal failure.
Discussion
This case highlights the diagnostic complexity and long-term management challenges in ovotesticular DSD with sex chromosome mosaicism. Even after early surgical intervention, residual ovarian tissue may become hormonally active at puberty. Lifelong multidisciplinary follow-up is essential to monitor endocrine function, psychosocial development, and oncologic risk in such patients.
Conclusion
Ovotesticular DSD with 46,XX/47,XXY mosaicism requires individualized, long-term care. This case underscores the importance of vigilant surveillance beyond early childhood, as hormonally active gonadal tissue may emerge later in development. Timely re-evaluation and organ-preserving interventions can support both endocrine stability and psychosocial well-being.
DOI: 10.5517/ccy8xcg
title: CCDC 872506: Experimental Crystal Structure Determination

description: Related Article: N.R.Madadi, S.Parkin, P.A.Crooks|2012|Acta Crystallogr.,Sect.E:Struct.Rep.Online|68|o730|doi:10.1107/S1600536812005843
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccy8xdh
title: CCDC 872507: Experimental Crystal Structure Determination

description: Related Article: N.R.Penthala, S.Parkin, P.A.Crooks|2012|Acta Crystallogr.,Sect.E:Struct.Rep.Online|68|o731|doi:10.1107/S1600536812005831
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.6084/m9.figshare.30407116.v1
title: Supplementary Material for: Ovotesticular Disorder of Sex Development with 46,XX/47,XXY Mosaicism: Challenges in Diagnosis, Gender Assignment, Gonadal Preservation, and Long-Term Oncologic Surveillance: A Case Report

description: Introduction
Ovotesticular disorder of sex development (DSD) is a rare condition, most commonly associated with a 46,XX karyotype. Mosaic karyotypes such as 46,XX/47,XXY are extremely uncommon and pose unique diagnostic and management challenges, particularly regarding gender assignment, gonadal preservation, and long-term surveillance.
Case Presentation
We report a patient with 46,XX/47,XXY mosaicism who presented at birth with ambiguous genitalia. Imaging and histology revealed a right testis, a left ovary, and both Müllerian and Wolffian structures. Following multidisciplinary evaluation and parental counseling, the child was raised as male and underwent staged masculinizing genitoplasty, including hysterectomy, vaginectomy, and hypospadias repair. At age 11, rising estradiol levels and gynecomastia led to the discovery of hormonally active ovarian tissue within the right gonad. Gonad-sparing reoperation was performed to remove the ovarian component while preserving testicular tissue. Histology confirmed the presence of follicles and intact seminiferous tubules. Despite favorable pathology, elevated gonadotropins indicated primary gonadal failure.
Discussion
This case highlights the diagnostic complexity and long-term management challenges in ovotesticular DSD with sex chromosome mosaicism. Even after early surgical intervention, residual ovarian tissue may become hormonally active at puberty. Lifelong multidisciplinary follow-up is essential to monitor endocrine function, psychosocial development, and oncologic risk in such patients.
Conclusion
Ovotesticular DSD with 46,XX/47,XXY mosaicism requires individualized, long-term care. This case underscores the importance of vigilant surveillance beyond early childhood, as hormonally active gonadal tissue may emerge later in development. Timely re-evaluation and organ-preserving interventions can support both endocrine stability and psychosocial well-being.
DOI: 10.5517/ccy8xfj
title: CCDC 872508: Experimental Crystal Structure Determination

description: Related Article: A.S.El-Azab, A.A.-M.Abdel-Aziz, S.W.Ng, E.R.T.Tiekink|2012|Acta Crystallogr.,Sect.E:Struct.Rep.Online|68|o732|doi:10.1107/S1600536812006253
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccy8xgk
title: CCDC 872509: Experimental Crystal Structure Determination

description: Related Article: A.S.El-Azab, A.A.-M.Abdel-Aziz, S.W.Ng, E.R.T.Tiekink|2012|Acta Crystallogr.,Sect.E:Struct.Rep.Online|68|o734|doi:10.1107/S1600536812006265
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.6084/m9.figshare.30405298
title: Supplementary Material for: Use of the Selective Cytopheretic Device with Continuous Renal Replacement Therapy in Children: A Comparison of Contemporary Cohorts

description: Introduction: The Selective Cytopheretic Device (SCD) is a cell-directed extracorporeal therapy approved for use in children with acute kidney injury (AKI) receiving continuous renal replacement therapy (CRRT) with sepsis/sepsis-like conditions. We compared outcomes for children treated with SCD to a contemporary cohort of children treated with CRRT alone. 
Methods: Secondary analysis and comparison of patients ≤22 years old and ≥10 kg from a multicenter registry of patients receiving CRRT for AKI and/or fluid overload (WE-ROCK; 2015-2021) to patients from two multicenter, prospective, interventional studies of children with AKI and multiple organ dysfunction (MODS) receiving SCD (SCD-PED-01/SCD-PED-02; 2016-2022). 
Results: Eighteen patients in the SCD Cohort were compared to 178 in the CRRT Cohort. There were no differences between cohorts at CRRT+/-SCD initiation. SCD patients had shorter CRRT duration (6 [3,11] vs. 10 [5,18] days, p=0.013) and shorter ICU length of stay (LOS) in survivors (16 [11,25] vs. 27 [16,46] days, p=0.012). Survival to ICU discharge or Day 60 was 94% in the SCD Cohort vs. 74% in the CRRT Cohort (p=0.079). A Bayesian analysis demonstrated a &gt;99% probability of improved survival with SCD. A sub-analysis in septic patients demonstrated greater survival (100% vs. 69%, p=0.032), shorter CRRT duration (5 [3,7] vs. 11 [6,17] days, p=0.006) and reduced ICU LOS in survivors (21 [10,25] vs. 27 [16,45] days, p=0.027) in SCD-treated patients. 
Conclusions: The addition of SCD therapy in children with AKI and MODS receiving CRRT may be beneficial, though larger prospective studies are needed.
DOI: 10.6084/m9.figshare.30405298.v2
title: Supplementary Material for: Use of the Selective Cytopheretic Device with Continuous Renal Replacement Therapy in Children: A Comparison of Contemporary Cohorts

description: Introduction: The Selective Cytopheretic Device (SCD) is a cell-directed extracorporeal therapy approved for use in children with acute kidney injury (AKI) receiving continuous renal replacement therapy (CRRT) with sepsis/sepsis-like conditions. We compared outcomes for children treated with SCD to a contemporary cohort of children treated with CRRT alone. 
Methods: Secondary analysis and comparison of patients ≤22 years old and ≥10 kg from a multicenter registry of patients receiving CRRT for AKI and/or fluid overload (WE-ROCK; 2015-2021) to patients from two multicenter, prospective, interventional studies of children with AKI and multiple organ dysfunction (MODS) receiving SCD (SCD-PED-01/SCD-PED-02; 2016-2022). 
Results: Eighteen patients in the SCD Cohort were compared to 178 in the CRRT Cohort. There were no differences between cohorts at CRRT+/-SCD initiation. SCD patients had shorter CRRT duration (6 [3,11] vs. 10 [5,18] days, p=0.013) and shorter ICU length of stay (LOS) in survivors (16 [11,25] vs. 27 [16,46] days, p=0.012). Survival to ICU discharge or Day 60 was 94% in the SCD Cohort vs. 74% in the CRRT Cohort (p=0.079). A Bayesian analysis demonstrated a &gt;99% probability of improved survival with SCD. A sub-analysis in septic patients demonstrated greater survival (100% vs. 69%, p=0.032), shorter CRRT duration (5 [3,7] vs. 11 [6,17] days, p=0.006) and reduced ICU LOS in survivors (21 [10,25] vs. 27 [16,45] days, p=0.027) in SCD-treated patients. 
Conclusions: The addition of SCD therapy in children with AKI and MODS receiving CRRT may be beneficial, though larger prospective studies are needed.
DOI: 10.5517/ccy8xhl
title: CCDC 872510: Experimental Crystal Structure Determination

description: Related Article: A.A.-M.Abdel-Aziz, A.S.El-Azab, S.W.Ng, E.R.T.Tiekink|2012|Acta Crystallogr.,Sect.E:Struct.Rep.Online|68|o736|doi:10.1107/S1600536812006137
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.6084/m9.figshare.30405298.v1
title: Supplementary Material for: Use of the Selective Cytopheretic Device with Continuous Renal Replacement Therapy in Children: A Comparison of Contemporary Cohorts

description: Introduction: The Selective Cytopheretic Device (SCD) is a cell-directed extracorporeal therapy approved for use in children with acute kidney injury (AKI) receiving continuous renal replacement therapy (CRRT) with sepsis/sepsis-like conditions. We compared outcomes for children treated with SCD to a contemporary cohort of children treated with CRRT alone. 
Methods: Secondary analysis and comparison of patients ≤22 years old and ≥10 kg from a multicenter registry of patients receiving CRRT for AKI and/or fluid overload (WE-ROCK; 2015-2021) to patients from two multicenter, prospective, interventional studies of children with AKI and multiple organ dysfunction (MODS) receiving SCD (SCD-PED-01/SCD-PED-02; 2016-2022). 
Results: Eighteen patients in the SCD Cohort were compared to 178 in the CRRT Cohort. There were no differences between cohorts at CRRT+/-SCD initiation. SCD patients had shorter CRRT duration (6 [3,11] vs. 10 [5,18] days, p=0.013) and shorter ICU length of stay (LOS) in survivors (16 [11,25] vs. 27 [16,46] days, p=0.012). Survival to ICU discharge or Day 60 was 94% in the SCD Cohort vs. 74% in the CRRT Cohort (p=0.079). A Bayesian analysis demonstrated a &gt;99% probability of improved survival with SCD. A sub-analysis in septic patients demonstrated greater survival (100% vs. 69%, p=0.032), shorter CRRT duration (5 [3,7] vs. 11 [6,17] days, p=0.006) and reduced ICU LOS in survivors (21 [10,25] vs. 27 [16,45] days, p=0.027) in SCD-treated patients. 
Conclusions: The addition of SCD therapy in children with AKI and MODS receiving CRRT may be beneficial, though larger prospective studies are needed.