cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.17603/ds2nd6f
title: RAPID: Large-Scale Shake Table Test to Quantify Seismic Response of Helical Piles in Dry Sand

description: This Rapid Response Research (RAPID) project investigated the seismic behavior of helical piles by means of shake table tests on full-scale piles in the UC San Diego laminar soil box. Helical piles are deep foundation elements that look like, and are installed like, a large steel soil screw - they have a slender steel shaft with any number of round plates welded to the central shaft at the tip to provide support to the structure they hold. Helical piles are spun into the ground with a large torque motor and provide support through soil bearing on the plates and along the shaft. They come in many lengths and are often the foundation of choice for retrofitting existing buildings or new, urban construction, due to their small footprint and ability to create minimal disturbance to surrounding structures. Even though it is known from anecdotal studies (e.g., New Zealand and Japan) that piles with comparatively small cross-section and high anchoring capacity, such as helical piles, are beneficial for seismic resistance seemingly due to their slenderness, higher damping ratios, ductility, and resistance to tip uplift, building codes and current state of practice have not been adequately developed for this pile type because no quantitative data exist. Research of seismic behavior of helical pile supported structures is therefore imperative to generate necessary data that will help ensure that helical piles are being correctly applied in seismic areas and establish quantifiable benefits and/or limitations of helical pile use in seismic areas. This project will benefit people living in seismic zones by educating engineers with full-scale helical pile experimental data so that they better understand how to design a building system that is safer, more resilient and sustainable for individuals and the community.
DOI: 10.17603/ds2v682
title: Hurricane Maria (2017) Simulation.
title: In Hurricane Maria ADCIRC Surge Guidance System Storm Surge Forecasts.

description: Output of ADCIRC+SWAN forecasts for Hurricane Maria 2017. Hurricane Maria struck Puerto Rico and threatened the U.S. coast in 2017. In this project, we show results from storm surge forecasts for Hurricane Maria based on the ADCIRC Surge Guidance System framework. These forecasts take data from the National Hurricane Center wind advisories, and generate storm surge predictions every 6 hours. In this project, we show the wind inputs used by the model and the computed maximum water levels for several of the advisories. For more information on the ADCIRC Surge Guidance System and its products, visit http://adcirc.org/products/adcirc-surge-guidance-system-forecasts/ or go to the Coastal Emergency Risk Assessment web site at www.cera.cct.lsu.
DOI: 10.17603/ds2-6ypr-q603
title: Prototype Masonry Buildings

description: Acceleration data of the test specimens were measured with ADXL345 accelerometers
DOI: 10.17603/ds2bq23
title: Identification of Urban Flood Impacts Caused by Land Subsidence and Sea Level Rise for the Houston-Galveston Region

description: Many severe hurricane-induced urban floods occurred in coastal communities in the recent decades (Harvey (2017), Isaac (2012), Ike (2008), Gustav (2008), Katrina (2005), Rita (2005), and Ivan (2004) etc.). The latest flood caused by Hurricane Harvey (2017) in the Houston-Galveston region (HGR) was regarded as one of the costliest disasters in the U.S. history, with damage exceeding $100 billion. Unfortunately, other than being vulnerable to natural hazards like hurricanes, many coastal cities also experience significant land subsidence (LS) and sea level rise (SLR) which exacerbate the urban floods. Traditional hydrologic and hydraulic modeling approaches often neglect the impacts of LS and SLR. Many previous studies have indicated the significance of the impacts imposed by LS and SLR to coastal communities, but incorporating both factors into flood inundation modeling and sustainable and resilient planning is still a challenge. Both SLR and LS are primarily due to human activities. The former is caused by global warming and the latter is owing to subsurface movement of earth materials. SLR and LS are two interrelated geo-environmental hazards which have rarely been considered in the existing urban flooding simulation in conjunction with extreme events. Thus, the PI and Co-PIs are motivated to establish the first and innovative methodology to understand and identify urban flood exacerbated by the contributing impacts from LS and SLR by achieving the following five objectives: I. To bridge fundamental gaps among the LS and SLR projection models, and the hydrologic and hydraulic simulation mechanisms (HHSMs) for urban flood modeling; II. To build corresponding HHSMs from 1992 to 2017 through modifications of topography along with the projected LS and SLR and calibrations for selected historical hurricane events (SHHEs); III. To identify the baseline flood conditions without considering any contribution from LS and SLR for each SHHE; IV. To quantify individual flood impact only due to LS and SLR, respectively, for each SHHE; V. To evaluate the combined flood impacts from LS and SLR for each SHHE. The Houston-Galveston region (HGR) with LS and SLR will be selected as the testbed for the proposed project. Given the facts that the HGR, a historical LS zone, has subsided up to 10 ft. since 1940s and that SLR is projected to rise another 1 to 4 ft. by 2100 by IPCC, it is very imperative for us to understand the contributing impacts from interconnected LS and SLR on urban floods.
DOI: 10.17603/ds2j67j
title: Centrifuge modelling of variable rate cone penetration in low-plasticity silts

description: This experimental program supports a broader project toward validating methods for the mechanics-based development of relationships between cone penetration test measurements and the engineering properties of intermediate soils.
DOI: 10.17603/ds28d72
title: Earthquake-Resistant T-shaped Concrete Walls with High-Strength Steel Bars

description: For many years, U.S. building codes for structural concrete have not permitted the use of high-strength reinforcing bars with a nominal yield strength greater than 80 ksi (550 MPa) for purposes other than as transverse reinforcement for confinement. Increased understanding and acceptance of high-strength steel bars would allow designers to reduce the amount of reinforcement used in structural members, resulting in less reinforcement congestion, simpler construction, and reduced cost. The main objective of this study is to determine the effect of the tensile-to-yield strength ratio of high-strength reinforcing bars on longitudinal reinforcement strain demands and on the overall behavior of slender T-shaped reinforced concrete walls. This investigation also aimed to determine the minimum uniform elongation required of high-strength reinforcement used in earthquake-resistant structures. Study of T-shaped walls is important because the shape of the cross-section results in larger longitudinal reinforcement tensile strain demands than in most other members. The effect of replacing conventional Grade 60 (420) reinforcement with a reduced amount of high-strength Grade 100 (690) reinforcement (with nominal yield strength of 100 ksi, or 690 MPa) is evaluated in this study using data from tests of large-scale reinforced concrete walls subjected to reversed cyclic displacements.
DOI: 10.17603/ds2-tshe-kd83
title: University of Auckland Lightly Reinforced Concrete Wall Tests

description: A series of experimental tests of large-scale lightly reinforced concrete walls were conducted at the University of Auckland.  The test were used to investigate minimum vertical reinforcement provisions and formed the basis for revisions to the New Zealand Concrete Structures Standard (NZS 3101:2006 (A3)) and the US Building Code Requirements for Structural Concrete (ACI 318-19). This dataset summarizes the results from the 11 tested walls including all sensor data (load cell, LVDT, string-pot displacement gauge, displacement transducer and strain gauge). Detailed instrumentation plan, loading protocol, test sequences, test observations and photos that were taken throughout the testing are also provided.  The dataset is intended to serve as a reference for future work, as well as an open resource to be used in future research.
DOI: 10.57967/hf/1180
title: piling-equipment
DOI: 10.57967/hf/1120
title: piling-equipment
DOI: 10.6084/m9.figshare.24239056
title: Holstein_Meta_Analysis_ Supplementary_Material

description: Supplementary Materials
DOI: 10.6084/m9.figshare.24239056.v1
title: Holstein_Meta_Analysis_ Supplementary_Material

description: Supplementary Materials
DOI: 10.25934/00003320
title: Analysis of Outcome Measures in Hidradenitis Suppurativa

description: There are a plethora of outcome measures for Hidradenitis Suppurativa (HS). The HiSCR (Hidradenitis Suppurativa Clinical Response) is the most well-known and widely used in clinical trials, however Physician Global Assessment (PGA), International Hidradenitis Suppurativa Severity Score (IHS4:developed by the European Hidradenitis Suppurativa Foundation Investigator Group) and the Acne Inversa Severity Index (AISI) have been recently developed since HiSCR was established. Given the multiple Phase 2 clinical trials currently active (and planned) in multiple monoclonal antibodies and antibody targets,  (IL-17, IL-23, IL-1 family) and small molecule therapies (JAK Inhibitors), comparing results across studies will be vital for patients and physicians to choose the most appropriate drug for their patients.

One issue vexing the interpretation of efficacy in Hidradenitis Suppurativa clinical trials is the heterogeneity of disease. It is clear from the collated PIONEER trial data (PIONEER 1, PIONEER 2 and PIONEER OLE), as well as from analyses of cytokine and immunohistochemistry data (work from our research group- currently unpublished but in press), that different states of disease in HS respond to different therapies.
This is likely due to the fact that in Hurley Stage 1 and 2 disease- TNF-alpha is the most prominent cytokine amenable to intervention, however feed-forward mechanisms invoking Th17 pathways emerge as the disease worsens to demonstrate psoriasiform hyperplasia and early upregulation of TGF-Beta – leading to early sinus tract formation.
As sinus tract formation and scarring are well established, a continual inflammatory loop mediated by fibroblasts, keratinocytes (via the role of ICAM-1 and TGF-Beta) perpetuates a keratinocyte-mediated inflammatory cascade which is less responsive to TNF-alpha inhibition. It is hypothesized by our group that this disease state would be more responsive to IL-1 or small molecular inhibition. Early scarring may be more susceptible to intervention with IL-17 inhibition, but once scarring and fistulisation is well established, IL-17 inhibition may only work to reduce discharge.

The relevance of this inflammatory dichotomy to clinical trials and outcome measures is that, in contrast to HiSCR (which does not take into account draining fistulae), other outcome measures weight draining fistulae very highly. For example, the IHS4 weights draining fistulae 4 times higher than number of nodules. 

Whilst all registered studies on clinicaltrials.gov use HiSCR as the primary outcome measure- other outcome measures are listed as secondary outcomes. Given the high weighting of draining fistulae in these other measures, one can hypothesize that relatively modest reductions in draining fistulae counts will lead to dramatic decreases in scoring for the IHS4 and AISI. This would result in an overestimation of effect, to the detriment of drugs such as Adalimumab, which can be effective in reducing draining fistulae, but which is not reflected by the HiSCR Data.
DOI: 10.25934/00003369
title: Predicting Treatment Response to Tumor Necrosis Factor Inhibitors in patients with ankylosing spondylitis

description: Axial spondyloarthritis (axial SpA) is a group of inflammatory spine conditions that affects 0.9-1.4% of general population, and ankylosing spondylitis (AS) is the prototypic disease.1   Tumor Necrosis Factor inhibitors (TNFi) have been widely used as the second line treatment for patients with active AS when patients have inadequate response to non-steroidal anti-inflammatory drugs (NSAIDs) or cannot tolerate NSAIDs.2   The treatment response to TNFi, however, is heterogenous.  In our previous systematic review of randomized control trials of TNFi in patients with AS, about one-half of the participants (39.% to 58.9%) achieved the Assessment in SpondyloArthritis international Society 40% response (ASAS40) at week 24, an indicator of major response3.  In clinical practice, both patients and clinicians are interested to know, how likely an individual patient will achieve a major response or remission after initiating TNFi therapy.  Although some studies have suggested baseline C-reactive protein (CRP) may predict therapeutic response to TNFi, other potential factors, such as disease duration, gender, HLA-B27 status, and the interactions between these features and with CRP, have not been examined.4  Therefore, limited information is available to assist clinicians and patients make treatment decisions based on expected efficacy.  The goal of our study is to investigate the predictive value of baseline clinical features for achieving a major response, in order to identify subgroups of patients more likely to have a meaningful clinical response to TNFi.  We plan to request and pool participant-level data from the active arms of randomized controlled trials of TNFi (adalimumab, etanercept, golimumab, infliximab) in active AS, and perform classification tree analysis to predict a major response to TNFi at week 12 and week 24.  Classification tree analysis would allow us to assess several predictors and their interactions at the same time, and the result will be in the form of probability score that can be used directly in clinical practice.  The results will help patients and physicians understand the likelihood of response prior to the start of TNFi, and may help in deciding who should not be treated with TNFi, or how soon to declare primary non-response.  In the future, a similar analysis of anti-IL17 medications may allow more personalized treatment.
DOI: 10.25934/00003762
title: The relative efficacy and safety of apalutamide, enzalutamide, abiraterone, and darolutamide for nonmetastatic castration-resistant prostate cancer

description: Until recently, nonmetastatic castration-resistant prostate cancer (nmCRPC) was managed with continued androgen-deprivation therapy (ADT) and surveillance for metastases. One-third of nmCRPC patients will develop metastasis within two years of diagnosis.[1] Progress has been made since 2018, when four antiandrogen drugs were evaluated to be efficacious for nmCRPC. Namely, apalutamide, enzalutamide, abiraterone, and darolutamide. [2-6]
While all four drugs are promising for nmCRPC, it is unclear which one performs best, as there have been no studies directly or indirectly comparing all of them. Such a comparison is important for decision-making, especially when drug costs are brought into the picture. All four drugs are patent-protected except abiraterone, for which the patent expired in October 2018. The monthly costs are estimated to be $3,275 for the generic version of abiraterone as compared to $12,196 and $12,065 for apalutamide and enzalutamide, respectively. The monthly costs are provided here because these drugs are to be used untill the development of metastases. The cost for darolutamide is yet to be determined as its new drug application has just been submitted to the FDA.
Considering the huge disparity in costs, it is critical to evaluate the relative efficacy and safety of these drugs and inform value-based decision-making. Are higher costs justified by better treatment effects or a better safety profile? Or is there actually no difference, making abiraterone is the most economic choice?
DOI: 10.25934/00004036
title: Dabigatran Integrated Analysis

description: Catheter ablation of atrial fibrillation (AF) is a well-established treatment. The most important complications associated with ablation of AF are thromboembolic events (stroke or transient ischemic attack) and bleeding events. Systemic anticoagulation before, during, and after ablation is important for the reduction of these risks. Recently, instead of conventional anticoagulants such as warfarin, direct oral anticoagulants (DOACs) have been used for the prevention of thromboembolic events in patients with AF. However, data assessing the safety and efficacy of anticoagulation therapy with DOACs during ablation of AF are limited. 

RE-CIRCUIT (listed in Vivli database, NCT02348723) and ABRIDGE-J (our data, UMIN000013129) are recently published clinical studies showing that anticoagulation therapy with dabigatran (a DOAC) was associated with fewer complications compared with warfarin therapy. The dabigatran administration protocols prior to ablation were slightly different in the 2 studies. Therefore, the aim of this study was to clarify the optimal administration protocol of dabigatran prior to ablation by integrated analysis of the 2 studies.
DOI: 10.5517/ccdc.csd.cc2g64lf
title: CCDC 2270024: Experimental Crystal Structure Determination

description: Related Article: Tae Hwan Noh|2023|CSD Communication|||
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2g69vv
title: CCDC 2270187: Experimental Crystal Structure Determination

description: Related Article: John D. Wallis, Jane O'Leary, Ian G. C. Coutts|2023|CSD Communication|||
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2g6dfj
title: CCDC 2270267: Experimental Crystal Structure Determination

description: Related Article: Jamal Mohamed Hamid Alaboosh|2023|CSD Communication|||
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2g6fz3
title: CCDC 2270315: Experimental Crystal Structure Determination

description: Related Article: Julius Oppenheim|2023|CSD Communication|||
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2g6g16
title: CCDC 2270317: Experimental Crystal Structure Determination

description: Related Article: Phuong-Truc Pham, Mamoun M. Bader|2023|CSD Communication|||
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2g6jhq
title: CCDC 2270393: Experimental Crystal Structure Determination

description: Related Article: Weiguang Yang|2023|CSD Communication|||
description: Related Article: Weiguang Yang, Danyang Luo, Guanrong Li, Weigao Hu, Jia Zheng, Lanmei Chen|2023|RSC Advances|13|22966|doi:10.1039/D3RA04082H
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2frcyj
title: CCDC 2256798: Experimental Crystal Structure Determination

description: Related Article: yinyin chen|2023|CSD Communication|||
description: Related Article: Yinyin Chen, Tianhua Cui, Hua Chen, Xue li Zheng, Haiyan Fu, Ruixiang Li|2023|Dalton Trans.|52|12368|doi:10.1039/D3DT01430D
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.25919/ezgv-zz29
title: Parkes observations for project P456 semester 2023APRS_15

description: The Parkes Pulsar Timing Array (PPTA) project has three primary goals: (a) detection of gravitational waves from astronomical sources, (b) establishment of a pulsar timescale, and (c) improvement of our understanding of Solar-system dynamics. We are now in an exciting regime where a signal detected in our (and other data sets) has the form expected for a gravitational wave background. We are therefore now attempting to confirm, or deny, this exciting result. With this proposal we aim to maintain our pre-eminent position in the field. Unlike most observing proposals, this is a continuing proposal for which the observations will continue to improve bounds on ultra-low-frequency gravitational waves until they are finally detected. Continued Parkes observations will remain valuable at least until the first stage of the SKA is able to improve on our sensitivity and observing cadence. Even after the gravitational wave background is detected we will want to continue observations in support of the nascent field of gravitational wave astronomy!
DOI: 10.25919/ngyv-sw33
title: Parkes observations for project P737 semester 2023APRS_07

description: The aim of this proposal is to carry out tests of the new backend instruments which cannot be carried out during standard maintenance periods. The scheduled time is used to measure beam shapes, determine polarisation calibration solutions and commission the National Facility observing modes for the new wide-band receiver.
DOI: 10.34740/kaggle/ds/3810751
title: indianhousesdatanalyses
DOI: 10.25919/kpqg-rt61
title: Parkes observations for project P574 semester 2023APRS_09

description: We request time to observe 260 pulsars on a regular basis in order to provide the accurate ephemerides necessary for the detection and characterisation of gamma-ray pulsars with the Fermi satellite. The main science goals are to increase the number of known gamma-ray pulsars (both radio loud and radio quiet), to determine accurate pulse profiles, and to characterise their high energy (phase-resolved) spectra. In the radio, the observations will also allow us to investigate: neutron stars and pulsar emission via detecting glitches and determining pulse timing parameters; and the ISM via measuring and monitoring dispersion measures, Faraday rotation measures, and scintillation. To date, we are (co-)authors on over 95 papers arising from the collaboration and P574 data, including four which use UWL observations. The data have contributed to the PhD theses of students from Bordeaux, Manchester, Oxford, Stanford, and Swinburne.