cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.4225/03/5897c5cf0d7b5
title: An investigation into the effect of in utero hypoxia on cerebral blood vessels and brain activity in late gestation fetal sheep.

description: Fetal hypoxia contributes significantly to the pathogenesis of permanent perinatal brain injury. Cerebrovascular pathology following hypoxia can lead to devastating and debilitating brain injury, such as that seen following stroke and haemorrhage, but the effect of in utero fetal hypoxia on the developing cerebrovasculature is not well understood. In the adult brain, robust up-regulation of vascular endothelial growth factor (VEGF) occurs following hypoxia and cerebral ischemia which results in the formation of new blood vessels, as an adaptive response to protect and repair the brain from hypoxic injury. However, newly-formed blood vessels are fragile and prone to rupture.
The aims of the studies described in this thesis were to determine how a single brief, but severe episode of fetal hypoxia in late gestation in sheep affects VEGF expression and the cerebral vasculature. We also determined the effects of this global hypoxia on fetal and neonatal behaviour to determine if the fetal brain can repair itself following a single brief hypoxic insult. The results show that 48 h after an in utero hypoxic insult, produced by 10 min of complete umbilical cord occlusion, the distribution of mean blood vessel size is greater in white matter but not gray matter, and there was greater blood vessel-associated VEGF expression white matter compared to gray matter. This was associated with disruption in blood brain barrier (BBB) permeability seen by increased extravasation of plasma albumin in white matter. When the fetuses were left in utero (5 – 10 days following UCO) until the onset of labour, increased VEGFR-2 expression was again seen in white, not gray matter.
These studies highlight the importance of assessing VEGF/VEGFR system following in utero hypoxia in the developing fetal brain. Studies assessing both fetal and newborn behaviour following in utero global hypoxia showed that fetal electrocortical (ECoG) activity and breathing movements were disturbed throughout late gestation, and after birth there were delays in the newborn lamb achieving important behavioural milestones such as the ability to stand, use all four legs, and find the udder and suckle. Therefore, it is concluded that an antepartum hypoxic event late in gestation does not result in the fetal brain being able to recover fully, resulting in persistent and profound changes in brain structure and pre- and post-natal behaviour.
DOI: 10.4225/03/5897c784a7496
title: The impact of household characteristics, socio-cultural factors and HIV/aids on child welfare in Kenya

description: This thesis investigates socio-economic and health economic issues related to the Kenyan people using the 2003 Kenya Demographic and Health Survey Data. The studies give empirical evidence that helps to understand the impact of socio-economic and health factors, including HIV/AIDS, on child schooling and health status. The thesis examines the factors contributing to an individual acquiring HIV, factors affecting child schooling and the factors having impact on child health in Kenya. Each of these studies employs the econometric tools necessary for reliable estimates. The econometric tools address issues with endogeneity, sample selection and missing data.
The thesis is comprised of five chapters with three major ones. The first Chapter gives an introduction and overview of the thesis. This chapter covers the motivation and objectives of the thesis. It also gives some historical background about Kenya. Chapter 2 examines the factors contributing to an individual acquiring HIV, with a focus on behavioural and personal characteristics, household characteristics and other socio-economic factors.
Chapter 3 deals with children’s education outcomes, specifically examining school attendance, school attainment, and rates of grade progression. The study focuses on the impact of individual and household characteristics. It incorporates the effect of socio-cultural factors as well as HIV/AIDS on child schooling. Extensive work is done on relevant econometric and statistical tools designed to address the difficulties associated with the variables used in the analysis. The discussion and conclusion gives some guidance to education policy makers in Kenya and other parts of the world which face similar conditions.
DOI: 10.5517/ccdc.csd.cc1mjkd3
title: CCDC 1505465: Experimental Crystal Structure Determination

description: Related Article: Nigel Gwini, David M. Marolf, Soo Hun Yoon, Audrey G. Fikes, Amanda C. Dugan, Gregory L. Powell, Vincent M. Lynch, Vladimir N. Nesterov, Gregory T. McCandless|2017|J.Organomet.Chem.|849-850|324|doi:10.1016/j.jorganchem.2017.01.026
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.14457/kmitl.the.2002.402
title: ความตระหนักเกี่ยวกับการป้องกันอันตราย จากสารเคมีของพนักงานในโรงงานอุตสาหกรรมเคมีภัณฑ์ เขตนิคมอุตสาหกรรมบางปู /
DOI: 10.14457/kmitl.the.2003.500
title: บทเรียนผ่านเครือข่ายอินเทอร์เน็ตวิชาวัสดุศาสตร์ /
DOI: 10.14457/kmitl.the.2003.506
title: การศึกษาแนวทางในการจัดผังบริเวณสถานีรถไฟ ในเขตกรุงเทพมหานครและปริมณฑล /
DOI: 10.14457/sut.res.2013.65
title: การเข้าถึงความรู้ทางการเกษตรด้วยเทคโนโลยีเว็บเชิงความหมาย
DOI: 10.4225/03/58940d0f07bb5
title: Young Indonesian-muslims in Australia:
 identity, family and the ummah

description: This study examines a group of Australian Indonesian-Muslim youths’ ways of being Muslim in relation to their experiences within their families and the Muslim community. Families and religious spaces are important social and educational sites for identity formation. In unpacking these young Indonesian Muslims’ ways of constructing and negotiating their Muslim identity, I interviewed 12 Muslim teenagers and their parents. The senior members of Indonesian Muslim community and the president of the Indonesian Muslim community of Victoria were also interviewed. The Indonesian youths also wrote personal narratives describing their experiences within their family as well as in the Muslim and broader community.

In this study, I look at the ways in which Muslim identity is represented in the religious texts, the Qur`ān and the Hadith. These two central religious texts describe essentialised understandings of Muslim identity, which define Muslims as those who submit and surrender totally to the will of Allāh and express their devotion through fulfilling their religious duties. I also draw on the works of Muslim scholars located in the west such as Basit (1997, 2009), Mondal (2008), Ramadan (2004), Yasmeen (2008) and Zine (2008) on ways of being Muslim. While acknowledging that the construction of Muslim identity is rooted in religious doctrine, these Muslim scholars in the West also believe that Muslim identity is socially and culturally constructed.

My research positionings as an insider and outsider are unpacked in this study. I share some similar experiences in being a Muslim like all my participants. Unlike, these young Muslims, however, I was born and have lived most of my life in Indonesia, a country with a Muslim majority. My educational and religious backgrounds are also different from those of my research participants.  

The findings of my study indicate that these Indonesian-Muslim youths’ experiences within their families and their community have significantly shaped their ways of understanding their Muslimness. These young Muslims hold essentialised understandings of Muslim identity, Australian identity and Indonesian identity.  They associate specific physical, social, and cultural markers with these essentialised identities, albeit drawing on these different markers differently in their own ways of being young Muslim. Three groups emerged in my study: Balancing being Muslim, Australian and Indonesian; Being practising Muslims, Indonesian and Australian, and Being strong Muslims, Indonesian and Australian.

These findings have provided insights into the ways in which Indonesian Muslim youth constructed their sense of Muslim identity within the Australian contexts. The findings also broaden understandings migrant communities and their cultural and religious experiences in Australia.
DOI: 10.4225/03/58940dd1ef002
title: Discovery and optimization of Grb7 antagonists as potential antitumor therapeutics

description: The growth factor receptor bound protein 7 (Grb7) is a non‐catalytic adaptor protein that was originally identified as a binding partner of the growth factor receptor (ErbB‐2). Amplification and overexpression of Grb7 is frequently implicated in the development of aggressive, recalcitrant and advanced tumor phenotypes making it a promising target in human cancers. Apart from several peptide‐based experimental antagonists, to date there exist no potent drug that is developed or known to act against Grb7. Thus, the overall objective of the research conducted in this thesis was to design novel, potent, selective and cell permeable Grb7 antagonists that may have potential as antitumor therapeutics. The first part of the thesis deals with optimization studies around a known lead polypeptide designed to bind to the Grb7 SH2 domain. A total of 11 polypeptides were synthesized with a yield varying from 2 to 17%. The peptide antagonists were found to have moderate binding affinity ranging from 0.6 – 60 μM as determined by isothermal titration calorimetry. Moreover, a short 7 residue cell permeablising sequence was incorporated into the inhibitor peptide construct and its ability to translocate peptides across membranes tested in in vitro and cell based assays. The second part of the thesis focused on small molecule antagonist discovery and optimization. Starting from known peptide leads and an experimental structure of the Grb7 SH2 domain, a series of ligand design techniques comprising shape based similarity searches, molecular docking and 2D‐similarity searching was effected to identify non‐peptide antagonists. In total, three structurally distinct classes of small molecular antagonists with moderate in vitro affinity and in vivo activity were identified from the study. The last part of the project reports the crystal structure determination of two Grb7 SH2 domain constructs. High‐resolution crystal structures of the apo‐ and peptide-bound forms of the Grb7 SH2 domain were determined. All together, extensive biophysical, computational and structural analyses were conducted on the Grb7 SH2 domain and ligands that will form the foundation for future Grb7 inhibitor development.
DOI: 10.14457/kmitl.res.2012.126
title: เนื้อหา ผลของการพัฒนาผู้เรียน และข้อเสนอแนวทางของการเรียนการสอนสาระ วิชารัฐศาสตร์ในฐานะวิชาการศึกษาทั่วไปในระดับปริญญาตรีของมหาวิทยาลัยไทย
DOI: 10.14457/kmitl.res.2013.144
title: การคัดกรอง และศึกษาอนุกรมวิธานเบื้องต้นของเชื้อแอคติโนมัยสีทในเนื้อเยื่อต้นต้อยติ่งที่สามารถสร้างสารปฏิชีวนะได้
DOI: 10.14457/kmitl.the.2003.501
title: บล็อกวงจรรวมแอคทีฟ สำหรับการสังเคราะห์อนาลอกฟังก์ชันเชิงระบบทำงานในโหมดกระแส /
DOI: 10.14457/kmitl.the.2003.503
title: การวิเคราะห์และออกแบบวงจรกรองกำลังแอกทีฟ แบบผสมแพสทีฟและแอกทีฟที่มีการชดเชยกระแสรีแอกทีฟและฮาร์มอนิก /
DOI: 10.14457/kmitl.the.2003.504
title: การใช้จีนีติกอัลกอริทึม และยูสเซอร์โปรไฟล์เพื่อการสืบค้นสารสนเทศจาก WWW /
DOI: 10.14457/kmitl.the.2003.505
title: เกณฑ์การออกแบบสภาพแวดล้อมทางกายภาพภายในที่อยู่อาศัยที่เหมาะสมต่อผู้สูงอายุ ในเขตกรุงเทพมหานคร /
DOI: 10.14457/sut.res.2013.69
title: การเตรียมผลึกนาโนซิลิคอนและการประยุกต์ใช้งานกับเซลล์แสงอาทิตย์
DOI: 10.4225/03/5897c934f01d5
title: Prehospital pain: epidemiology and management in Victoria, Australia

description: Pain is a commonly encountered condition in the prehospital and emergency medicine settings, and is associated with significant burden of disease.  This thesis explores the epidemiology of pain in the Victorian prehospital setting, and factors associated with the likelihood of clinically important pain severity reduction were identified from the interrogation of a large patient record database.  Seven factors were found to be associated with the likelihood of clinically important pain reduction following multivariate analyses.  These included: age, time criticality of the patient, pain aetiology, initial pain severity, analgesic agent or combination administered to the patient, scene time, and transport time.  

In 2007, ketamine was trialled in the prehospital setting as an analgesic agent.  In this prospective, randomised controlled trial, the administration of morphine followed by ketamine was found to be superior to morphine alone in the reduction of pain intensity in adult patients with moderate to severe pain following trauma in the prehospital setting.  Intravenous ketamine provided safe and effective analgesia to adult patients following injury. After accounting for differences between trial cluster sites, patients in the ketamine group had a mean verbal numerical rating scale (VNRS) pain reduction of 5.6 points compared with the M-group of 3.2 points (p&lt;0.0001).   

This study followed participants up to 12 months following enrolment into the ketamine study, identified those who continued to suffer from persistent pain, and assessed their health-related quality of life using the SF-36 questionnaire.  Statistically and clinically, there was no difference in the long term follow up between study groups with respect to the summary measures, subscale measures or global pain score. 

In light of the superiority of intravenous ketamine over morphine to reduce pain intensity in patients with moderate to severe traumatic injury, this agent warrants consideration by all emergency medical services (EMS) who have appropriate training and clinical governance.  Furthermore, ketamine was administered in a safe manner in this non-physician EMS setting.  It is likely that this work will result in Ambulance Victoria introducing ketamine as an alternative analgesic agent for the prehospital management of moderate to severe pain in trauma patients, and has the potential to influence change in EMS and emergency medicine practice nationally and internationally.  

In time, hopefully, these studies will make a major contribution to the early management of injured patients. Improved early management of pain and interventions aimed at other related factors could lead to more efficient rehabilitation, demonstrable decreases in morbidity, and improved quality of life.
DOI: 10.4225/03/5897ca9614924
title: Inhibition of oxidative protein folding in gram-negative bacteria : fragment-based design of DsbA inhibitors.

description: The disulfide-dithioloxidoreductase enzyme DsbA is an oxidative folding catalyst found
in the bacterial periplasm and is a key determinant of virulence in Gram-negative
pathogens. DsbA has a wide spectrum of substrate specificity and has been demonstrated
to catalyse the formation of disulfides in numerous secreted proteins. DsbA operates at a
central point in the production of virulence-determinants because most virulence factors
are proteins that require disulfide bonds to be active. DsbA knockout mutants in E. coli,
have been shown to be impaired in a range of processes related to virulence.
Significantly, DsbA mutations in many pathogenic bacteria attenuate their virulence,
demonstrating the value of targeting DsbA to develop anti-bacterial agents to counteract
virulence. DsbA is a structurally as well as functionally well characterized protein which
has no direct homologue in eukaryotes. To date there are no known small molecule
inhibitors of this protein. Hence DsbA represents an attractive antibacterial target and is
the protein of interest for this project.
The current thesis reports the identification of scaffolds that are suitable starting points for
designing inhibitors of DsbA. These scaffolds were identified using a fragment-based
drug design (FBDD) approach. This study describes a structure assisted-FBDD process
performed to validate DsbA as an antibacterial drug target. A broad range of
complementary techniques were employed to identify inhibitors of DsbA from two
different Gram negative bacterial species; Escherichia coli and Vibrio cholerae. NMR
based screening of a fragment library was carried out in two rounds. Theprimary screen
employed STD (Saturation Transfer Difference) experiments to identify candidate hits and 1H-15N HSQC (Heteronuclear Single Quantum Coherence) experiments were used
to confirm binding. A number of strong hits were identified and the binding locations
were identified from the HSQC data. The binding efficiency of the fragments was
determined by calculating NMR-based dissociation constants.Several of these initial
binding fragments also show inhibitory activity in a phenotype assaysin E.coli. X-ray
crystallographic studies revealed that the most potent fragment hits bind in the
hydrophobic groove of EcDsbA in adjacent or overlapping positions.
Charactisation of the structures of complexes of EcDsbA with theoriginal NMR hits was
followed by fragment elaboration through structure-guided medicinal chemistry efforts.
Preliminary structure-activity relationships(SAR) were identified for several series. This
SAR will facilitate the development of novel DsbA inhibitors that specifically target
functionally important protein surface sites.
In conclusion, this study presentsthe discovery of novel small molecule inhibitors of
DsbA and provides insights into the development of potential DsbA inhibitors as
antibacterial drug candidates.
DOI: 10.14457/kmitl.res.2013.147
title: การศึกษาการใช้ประโยชน์ Spirodela polyrrhiza ในการผลิตเอธานอล
DOI: 10.4225/03/5897c998e203e
title: The lost comedian (a novel) & beyond the latticed view:  translating self, memory and place in a second language (exegesis)

description: The thesis consists of two parts, a creative component and an accompanying exegesis.
     My novel, The Lost Comedian, explores a young girl’s struggle to find her own moral compass through a religious crisis, her relationships with her peers and with adults in positions of power. It is mainly set in Sweden in the 1960s and 70s, but also moves back to the 1930s. By the time of her father’s death, the protagonist, Christina, is living a modest life in bay-side Melbourne. She returns to Sweden from Australia for her father’s funeral, and is confronted with her past and memories of growing up in the religious community of Svenstorp. The novel entwines two themes: 1) Christina’s development from a child with a strong sense of belonging and identity as a “Believer” to a teenage rebel, and the consequences of her rebellion; 2) Christina’s recovery from a secret, deeply personal loss that she has encountered in Melbourne, and the ever-present temptations of surrendering to a sense of guilt, punishment and self-destruction as a consequence of the “pagan” way of life to which she surrendered as a teenager in Sweden.  
     The exegesis, “Beyond the Latticed View: Translating Self, Memory and Place in a Second Language,” focuses on the linguistic and cultural translation processes when writing in a second language. Investigating gains and losses of this translation process, the exegesis explores the prospect of a “new” sense of self emerging in the “new” language. Specific Swedish social, literary and cultural influences that inform the novel are discussed in the context of its setting. The exegesis also examines the cultural translation processes that these influences instigate, and how writing from both a spatial and temporal distance when “translating” the past influences the novel. As well, practical translation issues when writing from an “other” culture and language are explored. While reflecting on the many challenges when writing in translation, the exegesis argues that translating “self, memory and place,” ultimately creates a richly rewarding narrative.
DOI: 10.17632/v25pzywt5c.1
title: Statistical behavior of the tensile properties of natural fibre composites

description: This .zip folder features raw stress-strain tensile data for approximately 500 specimens corresponding to different natural fibre reinforced composite laminates (see Raw Data folder). In addition, we provide here the calculated elastic modulus, strength and failure strain values for each specimen (see Statistics folder). Finally, we include python codes that enables to show the experimental statistical distributions for each material system and calculate the corresponding fit of their probability distribution functions (see Normal.py and Weibull.py files). The data presented here is associated with the research articles "Statistical behavior of the tensile properties of natural fibre composites" and "The mechanical properties of natural fibre composite laminates: a statistical study" by J.P. Torres, L.-J. Vandi, M. Veidt, M.T. Heiztmann.
DOI: 10.4225/03/5897c98929cbc
title: Targeting the NO/sGC/cGMP signaling pathway in health and disease

description: The therapeutic utility of the nitric oxide (NO)/soluble guanylyl cyclase (sGC)/cyclic guanosine 3’5’-monophosphate (cGMP) pathway is well-recognised, with NO donors used in the treatment of diseases such as heart failure, acute hypertensive crisis and pulmonary hypertension. However, traditional nitrovasodilator therapy is somewhat limited due to the development of tolerance following prolonged administration. Furthermore, in vascular disease states such as hypertension, the NO/sGC/cGMP pathway appears to be dysfunctional. Such dysfunction is thought to arise as a consequence of oxidative stress and the associated increase in vascular superoxide anion radical (•O2-) levels, leading to enhanced scavenging of NO to form the oxidant, peroxynitrite (ONOO-). Indeed, ONOO- is able to oxidise the reduced (Fe2+) heme group of sGC, converting it into its NO-insensitive ferric (Fe3+) or heme-free forms. Under such conditions, the efficacy of NO donors/nitrovasodilators are compromised, due to their inability to target these altered states of sGC, underlining the need for novel non-NO based compounds. As such, this thesis examines the vaso-protective actions and therapeutic potential of the redox sibling of NO, nitroxyl (HNO), as well as NO-independent sGC stimulators (BAY 41-2272) and activators (BAY 58-2667) in a number of cardiovascular disease states.
From a clinical perspective, NO-independent compounds such as HNO donors and/or stimulators and activators of sGC may offer considerable therapeutic advantages over traditional nitrovasodilator therapies due to their well-documented resistance to •O2- scavenging and vascular tolerance development, as well as the ability to target oxidised/heme-free sGC (i.e. BAY 58-2667) and the potential to mediate their effects via cGMP-independent mechanisms of action. Such compounds may also offer the basis from which future therapies, for the treatment of cardiovascular diseases, are designed.
DOI: 10.4225/03/5897ca0bc6d4e
title: Monitoring respiratory function during neonatal resuscitation

description: The studies presented in this thesis show that a RFM can be used during mannequin based neonatal training program to: 1) teach correct mask hold and positioning techniques to diminish leak; 2) teach assessment of PIP and PEEP; 3) teach assessment of tidal volumes and adjustment of PIP to deliver an appropriate tidal volume. During neonatal resuscitation a RFM can provide continuous information about: 1) tidal volume 2) mask or ETT leak, 3) tube placement after endotracheal intubation, 5) the PIP and PEEP being delivered. In addition, I believe it provides valuable information about 1) ventilation rate, 2) inflation and expiration times, 3) the spontaneous breathing patterns, tidal volume and interaction with the inflations. Awards: Winner of the Mollie Holman Doctoral Medal for Excellence, Faculty of  Medicine, Nursing and Health Sciences, 2011.