cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.23661111
title: Supplementary Material for: Effect of first-line therapy with osimertinib for a metastatic choroidal tumor in advanced-stage lung cancer: A case report

description: Although the advent of molecular-targeted drugs has improved the prognosis of various cancers, the long-term prognosis and side effects as first-line therapy for metastatic choroidal tumors remain unclear. We describe a case in which first-line therapy of osimertinib has shown long-term successful and minimum side effect responses for metastatic choroidal tumors in a patient with advanced-stage lung cancer. The patient was a 62-year-old man who complained of foggy vision and visual field defects in his left eye for one month. When he visited his local doctor, a serous retinal detachment was noted in the left eye, and he was referred to our hospital for further examination. The patient had no history of systemic disease. A fundus examination of his left eye showed a slightly elevated choroidal lesion along with the superior retinal vascular arcade. Optical coherence tomography showed a serous retinal detachment around the lesion. Fluorescein angiography showed that the site of the lesion had spotty and mottled hyperfluorescence in the early phase and ring hypofluorescence in the late phase. We suspected a metastatic choroidal tumor and performed a whole-body computed tomography scan, which indicated lung cancer and metastasis to the left iliac bone. The patient was referred to the department of respiratory medicine of our hospital, and after a thorough examination, a diagnosis of lung adenocarcinoma (stage IV-B, epidermal growth factor receptor (EGFR) gene mutation positive) was made. Treatment with osimertinib was initiated, and shrinkage of the primary tumor was observed. The elevated choroidal lesion and serous retinal detachment resolved after two months of treatment, and no recurrence was observed during the 20 months of treatment. The use of osimertinib as primary treatment for EGFR mutation-positive lung cancer was found to significantly reduce the size of metastatic choroidal tumors and to have a relatively long-lasting antitumor effect without serious ocular complications.
DOI: 10.6084/m9.figshare.24138879
title: Supplementary Material for: Long-term follow-up of a family with retinal dystrophy caused by RPE65 mutation

description: We present here the case histories of two siblings, a boy and a girl, with Leber’s congenital amaurosis (LCA). The diagnosis was based on non-recordable full-field electroretinogram (ffERG). The long- term ophthalmologic follow-up included kinetic perimetry (Goldmann), visual evoked potentials with flash stimulation (FVEPs), optical coherence tomography (OCT: B-scan images at the area of fovea.), and multifocal ERG (mfERG). The boy (Sibling 1, born in 1986) was sent for electrophysiological examination at the age of four because he had nystagmus from birth. The diagnosis would be LCA based on non-recordable ffERG. Four years later, his visual acuity decreased rapidly due to vitreous opacification, caused by the autoimmune reaction of the retinal pigment epithelial (RPE) cells. This was treated successfully with steroid injections, administered parabulbarly. Retinal autoimmune panel was not performed. Genetic testing became available only in 2019, and it revealed a RPE65 gene mutation: (NM_000329.2) c.{442G&gt;A};{442G&gt;A} (p.{Glu148Lys}; {Glu148Lys}). His sister (Sibling 2, born in 1993) showed similar symptoms, caused by the same genetic mutation. Even though their parents were free of symptoms, it appeared that they were heterozygous carriers of the same mutation. Research of the family tree revealed a consanguineous marriage four generations before. Both siblings received successful gene therapy relatively late in their age: Sibling 1 was 35 and Sibling 2 was 28 years old, meaning that they were at an advanced stage of the disease. Nevertheless, follow-up examinations showed measurable improvements in their retinal function. The study shows that electrophysiological examinations, including flash-evoked responses, are useful in the objective evaluation of the progression in the central photoreceptor loss during the follow-up of LCA. The results also show that gene therapy can have beneficial effects even at an advanced stage of the disease.
DOI: 10.6084/m9.figshare.24166554
title: Supplementary Material for: Sterile corneal infiltrates following cataract surgery: case series.

description: We report a case series of twenty-six eyes of 26 patients undergoing planned cataract surgery from December 2021 to March 2022, who were diagnosed as having whitish round infiltrates in the surgical corneal incisions. The infiltrates were detected at the first check after 5 to 8 days from cataract surgery and were located either within the main corneal incision and/or in the smaller incisions. Corneal infiltrates (CIs) were single or multiple, without epithelial defects and painless. All infiltrates were initially treated with full topical antibiotic coverage, in order to control eventual and serious post-surgical infection. However, at daily checks, the clinical course of CIs suggested a sterile etiology. For this reason, steroidal topical treatment was maintained for a long time with slow tapering until complete remission of the CIs. All infiltrates resolved completely in around 30-40 days. The surgical instruments and the sterilization process were scrutinized. A white amorphous material was found mainly on non-disposable anterior chamber cannulas and on I/A tips. Disposable cannulas were adopted, and machinery for cleaning and sterilization procedures were reviewed, with specific reference to water softener renewal. Thanks to these precautions, CIs never occurred again. Finally, our hypothesis was an immune corneal reaction to amorphous deposit on cannula tips. This case series describes a previously unknown complication of cataract surgery and our experience might be useful for other surgeons.
DOI: 10.6084/m9.figshare.24218532
title: Supplementary Material for: Aggressive fibromatosis of the left Mesocolon mimicking a gastrointestinal stromal tumor: A ase report

description: Mesenteric Fibromatosis [MF] is a proliferative fibroblastic lesion of the intestinal mesentery. It constitutes 8% of all desmoid tumors, representing 0.03% of all neoplasms. It is benign histologically, although it could infiltrate locally and recur following excision; however, it is free from the potential to metastasize. It is spontaneous or associated with Familial Adenomatous Polyposis Mutation [FAP] as a part of Gardner's syndrome. This case report discusses the radiological, intraoperative, and histopathological findings from a 45-year-old male patient who presented with abdominal pain and a palpable mass in the left hemiabdomen. The pain was dull and aching, extending to the back and unrelated to any other gastrointestinal symptoms. There was no history of severe weight reduction. Furthermore, he is not a smoker. There were no comorbidities, severe medical diseases, or prior surgical procedures. Computerized tomography revealed a well-defined, lobulated, heterogeneously enhancing altered signal intensity mass at the mesocolon. Ultrasonography of the abdomen showed an intra-abdominal mass. Macroscopic mass characteristics include a well-defined mass measuring 22X14X11cm connected to a small intestine segment measuring 21x2x2cm. Histopathological and immunohistochemical examinations of the resected tumor, including positive nuclear immunostaining for beta-catenin, confirmed a postoperative diagnosis of desmoid-type fibromatosis. Based on its clinical presentation and computed tomography results, this case demonstrated how desmoid-type fibromatosis of the colon might mimic gastrointestinal stromal tumors [GIST]. Due to the varied therapies and follow-up methods used for these lesions, the differential diagnosis between desmoid type fibromatosis and GIST is clinically significant.
DOI: 10.7488/ds/3758
title: SUPERSEDED - Dataset: The effects of caloric restriction on adipose tissue and metabolic health are sex- and age-dependent
title: Literature search for mouse and human caloric restriction studies from 2003-2021
title: Source data for caloric restriction manuscript

description: ## This item has been replaced by the one which can be found at https://datashare.ed.ac.uk/handle/10283/4810 - https://doi.org/10.7488/ds/3817 ##. These are the source data and code underlying the figures presented in this preprint https://doi.org/10.1101/2022.02.20.481222. For further details please see the file named readme_Sex_Differences_Adipose_Tissue_Metabolism_dataset.txt.
description: The dataset consists of three Excel files, two code files (in R) and one readme (.txt) file, as follows: 1. Sex_Differences_Paper_Source_Data_all_figures_v2022_09_08.xlsx 2. MASTER_ Pubmed_result Mice NOT reviews_v2022_04_17.xlsx 3. MASTER_ Pubmed_result Humans NOT reviews_v2022_04_25.xlsx 4. PCA_for Ben_v3_qPCR.R 5. PCA_for Ben_v3_ceramides.R 6. readme_Sex_Differences_Adipose_Tissue_Metabolism_dataset.txt The first Excel file contains the source data for the figures presented in the manuscript. The second and third Excel files contain further data that are the basis for the literature reviews summarised in Figure 1 and Supplemental Figure 1. The fourth and fifth files are R code used for doing the Principal Component Analyses (PCA) presented in Figures 6B and 6F. The sixth file (readme) contains this dataset description along with other metadata.
DOI: 10.5445/ir/1000093970
title: Water vapour profiles from WAVAS SAtellite component in HARmonized format (WAVAS_SAHAR)

description: This is the databank of satellite vertical profiles of the water vapour, that have participated in SPARC WAVAS assessment, in a harmonized format, WAVAS_SAHAR. All vertically-resolved satellite measurements of the tropospheric and stratospheric water vapour in the time period between 1984 and 2018 are included. The databank consists of water vapour profiles retrieved from each instrument, which are screened for invalid data according to recommendations of instruments’ teams, then transformed into a common unit and interpolated on a common grid. The data versions included are those existing at the moment of WAVAS exercise, hence not always the most recent at the time of publishing.
DOI: 10.6084/m9.figshare.23531508
title: Supplementary Material for: Real-World Evaluation of Demographics, Treatment Pattern, and Economic Burden of Heart Failure and Kidney Disease in Type 2 Diabetes Mellitus Patient Population in Dubai, United Arab Emirates

description: <b><i>Aims:</i></b> The current study evaluated the demographics, clinical characteristics, treatment patterns, and economic burden of patients with type 2 diabetes mellitus (T2DM) with comorbidities (heart failure [HF], chronic kidney disease [CKD], and cardiovascular disease [CVD] without HF) in Dubai, United Arab Emirates (UAE). <b><i>Methods:</i></b> This observational, retrospective study collected data from January 01, 2014, to December 31, 2019, from the Dubai Real-World Claims Database (adults ≥18 years; at least 1 T2DM diagnosis claim). Patients were stratified into 5 cohorts: T2DM alone (cohort 1), T2DM and CKD (cohort 2), T2DM and CVD without CKD and HF (cohort 3), T2DM and HF (cohort 4), and T2DM with HF and CKD (cohort 5). An evaluation of demographics and clinical characteristics during pre-index period, as well as treatment patterns, healthcare resource utilization, and costs during the post-index period was conducted. <b><i>Results:</i></b> The sample had 374,271 patients with T2DM (age 43–56 years; male [72–84%]). Patients in cohorts 4 and 5 had Deyo-Charlson Comorbidity Index scores of 4.4 and 5.8, respectively. General practitioners (GPs) routinely prescribed biguanides for patients in cohorts 1–4 (24–38%), and insulin to patients in cohort 5 (27.7%). Prescription rates of novel antihyperglycemic drugs, such as glucagon-like peptide-1 (GLP-1 RA), were very low (∼2–8%) even in cohorts with cardiovascular and renal comorbidities (cohorts 2–5). A similar observation was noted with prescribing rates (0.6–4.4%) of sodium-glucose cotransporter-2 inhibitors (SGLT-2i) in cohorts 2–5. Endocrinologists preferred to prescribe GLP-1 RA and SGLT2i to T2DM patients with comorbidities. During the 5-year study period, median outpatient claims were the highest in cohort 5 (8.0 [range, 1.0–168.0]), followed by cohort 2 (5.5 [range, 1.0–52.0]). The median cost for inpatient claims was higher in cohort 5 (16,429 [range, 3,732–29,126] AED) compared to other cohorts. The median cost for drugs and procedures was highest in cohort 5 (4,525 [range, 38–31,546] AED and 2,297 [range, 56–105,074] AED, respectively). <b><i>Conclusion:</i></b> Continued and increased usage of drugs such as SGLT2i and GLP-1 RA with proven cardiorenal benefits could improve long-term outcomes and reduce associated healthcare costs in patients with T2DM and comorbidities in Dubai, UAE.
DOI: 10.18167/dvn1/dbyzxu
title: Plos NTD research article - A participatory epidemiological and One Health approach for surveillance opportunities

description: This dataset includes the supporting information files related to the research article entitled "A participatory epidemiological study to build a community-based surveillance system of emerging zoonoses in Guinea" submitted to the journal Plos Neglected Tropical Diseases. This dataset includes diseases-clinical signs matrix (S1 Matrix), ranking and scoring of clinical signs (S2 Matrix) and pictures of flow diagrams representing the health information exchange networks (S1 Picture) conducted with human health (women and community human health workers), animal health (breeders and community animal health workers) and ecosystem health (hunters and community informants) actors through Focus Group Discussions in Forest Guinea in 2019. This study was conducted in the framework of the Ebosursy project.
DOI: 10.25914/508x-9a12
title: AURA - Operational Radar Network Level 1 Archive

description: The level 1 dataset consistents of uncalibrated and uncorrected radar volumes in their native spherical coordinate system. This data is provided "as is" and users who need corrections should use level 1b and level 2 datasets. This dataset is intended for use by radar scientists and data analysts who have an understanding of the issues which may be present in weather radar datasets. Applications include performing radar calibration and analysis that require uncorrected radar data. The data resolution, frequency, fields and number of levels depend on the weather radar hardware used to collect the information, and therefore varies considerably across the dataset.
DOI: 10.12751/g-node.vy1zjd
title: Gallant Lab Natural Short Clips 3T fMRI Data

description: This data set contains BOLD fMRI responses in human subjects viewing a set of natural short clips. The functional data were collected for five subjects, in three sessions over three separate days for each subject. Details of the experiment are described in the original publication.
description: IsSupplementTo: Nishimoto, S., Vu, A. T., Naselaris, T., Benjamini, Y., Yu, B., & Gallant, J. L. (2011). Reconstructing visual experiences from brain activity evoked by natural movies. Current biology, 21(19), 1641-1646. (https://doi.org/10.1016/j.cub.2011.08.031)
description: IsSupplementTo: Huth, A. G., Nishimoto, S., Vu, A. T., & Gallant, J. L. (2012). A continuous semantic space describes the representation of thousands of object and action categories across the human brain. Neuron, 76(6), 1210-1224. (https://doi.org/10.1016/j.neuron.2012.10.014)
description: IsReferencedBy: Huth, A. G., Lee, T., Nishimoto, S., Bilenko, N. Y., Vu, A. T., & Gallant, J. L. (2016). Decoding the semantic content of natural movies from human brain activity. Frontiers in systems neuroscience, 10, 81. (https://doi.org/10.3389/fnsys.2016.00081)
description: IsReferencedBy: Popham, S. F., Huth, A. G., Bilenko, N. Y., Deniz, F., Gao, J. S., Nunez-Elizalde, A. O., & Gallant, J. L. (2021). Visual and linguistic semantic representations are aligned at the border of human visual cortex. Nature Neuroscience, 24(11), 1628-1636. (https://doi.org/10.1038/s41593-021-00921-6)
DOI: 10.12760/03-2014-10
title: Hyperspectral data for classification of selected vegetation species above tree-line in the Krkonoše Mts. National Park

description: The paper is focused on the classification of vegetation above the tree-line in the Krkonoše Mts. National Park (KRNAP) using hyperspectral data (APEX). The vegetation above tree-line (altitude above 1350 m) is the unique ecosystem which is characterized by mosaic of subalpine meadows with Nardus stricta and Pinus mugo growths, subalpine peat-bog, rocks and another areas of the lichen tundra in the highest parts in the Krkonoše Mts. Studying of Pinus mugo and competitive strong grasses (Molinia caerulea and Calamagrostis villosa) expansion to the original meadows with Nardus stricta is very important issue for environmental protection. The aim of this study is to classify two species Nardus stricta and Calluna vulgaris spatial distribution in the western part of tundra in the Krkonoše Mts. National Park. Different classification methods (e.g.  support vector machine, spectral information divergence or spectral angle mapper) are used and evaluated. The goal is to find best classification method providing the most accurate outputs. The detailed abundance maps of Nardus stricta and Calluna vulgaris are also produced.
DOI: 10.21335/nmdc-1248407516
title: Chlorophyll A and phaeopigments Nansen Legacy cruise 2021708

description: This dataset is a collection of the acid-corrected chlorophyll A and phaeopigments measurements taken as part of the Nansen Legacy project (www.arvenetternansen.com), as part of the '2021 Joint Cruise 2-1' cruise.
DOI: 10.5281/zenodo.5651194
title: ML-TOMCAT V1.0: Machine-Learning-Based Satellite-Corrected Global Stratospheric Ozone Profile Dataset

description: MLTOMCAT is 42 years (1979-2020) of gap free ozone profile data sets that is created by correcting biases in a TOMCAT Chemical Transport Model (CTM) simulated ozone profiles. We use Random Forest regression model to correct model biases. Each file contain monthly mean zonal mean ozone profiles. There are 4 data files. MLTOMCAT_1979_2020_72_ht_vmr.nc contains ozone profiles on geometric height levels (1 to 60 km) in mixing ratio units, whereas MLTOMCAT_1979_2020_72_ht_nd.nc contains ozone profile in number density units. Similarly, MLTOMCAT_1979_2020_72_plev_vmr.nc contains ozone profiles on 43 MLS pressure levels (1000 to 0.1 hPa) in mixing ratio units, whereas MLTOMCAT_1979_2020_72_plev_nd.nc contains ozone profile in number density units. Please note that data below 300 hPa (~8km) and 1 hPa (~50 km) should be used with caution. A manuscript describing MLTOMCAT would be published in EESD (Dhomse et al., 2021)
DOI: 10.6084/m9.figshare.11303372
title: Intracranial aneurysm genome-wide association study summary statistics 2020

description: <b>Summary statistics of a genome-wide association study of intracranial aneurysms in 10,754 cases and 306,882 controls.</b><b><br></b><b>Dataset described in: </b>Genome-wide association study of intracranial aneurysms identifies 17 risk loci and genetic overlap with clinical risk factors<b><br></b>Bakker, M.K. et alNature Genetics, 16 November 2020doi: 10.1038/s41588-020-00725-7https://www.nature.com/articles/s41588-020-00725-7<br><b><br></b>The study consisted of 2 stages. Stage 1: European ancestry only. Stage 2: European and East Asian ancestry.Extra files:-Association statistics of the East Asian subset only.-Association statistics of only aneurysmal subarachnoid hemorrhage versus controls-Association statistics of only unruptured intracranial aneurysms versus controls-Association statistics excluding the UK Biobank (4 files): Stage 1 excluding UK Biobank, Stage 2 excluding UK Biobank, European-only aSAH-only excluding UK Biobank, and cross-ancestry aSAH-only excluding UK Biobank.<br>Please check the <b>Data Access Policy</b> for further information regarding data use, access and options for additional analyses.
DOI: 10.6084/m9.figshare.13190702
title: Phenotype data

description: These files contain body weight measurements of all mice in the study, up until 22 months of age1. the raw body weight measurements, measured every 10 days2. l1-trend filtered body weight estimates, every 10 days
DOI: 10.6084/m9.figshare.13190708
title: Significant variants / genes

description: The variants, and linked genes, that are significantly associated with body weight at multiple ages, in both diet-independent and diet-dependent manners, are enumerated in these files.
DOI: 10.6084/m9.figshare.13190735
title: Genotype data

description: These data include 1. the genotypes for all mice at ~110,000 typed variants; genotypes are represented as a probability vector quantifying the founder of origin of each variant2. the genotypes for all mice at ~32.5 million segregating variants (imputed and typed); genotypes are represented as fraction of total dosage contributed by the non-reference allele (i.e., multiply by 2 to compute the dosage for diploid organisms).3. the kinship between all pairs of mice, both using all chromosomes, and leaving each chromosome out (for QTL mapping)
DOI: 10.6084/m9.figshare.21205952
title: Supplementary Material for: The impact of breast awareness on the early detection of breast cancer in young women: A systematic review

description: Background ‘Breast awareness’ is a recommendation that women understand the symptoms of breast cancer and become familiar with the usual look and feel of their breasts. It is recommended for women of all ages in breast cancer screening guidelines around the world. The objective of this study was to assess the evidence for breast awareness by investigating its effect on breast cancer outcomes in women of pre-mammographic-screening age (under age 40), at average risk of breast cancer. Methods A systematic review was performed using PRISMA methodology. Following the search, abstracts and full text articles were assessed against eligibility criteria. Data were extracted into evidence tables, risk of bias was assessed, narrative synthesis was performed and results were described. Eligible studies were original research studies assessing the impact of breast awareness on cancer outcomes (such as stage at diagnosis or survival) in women ≤40. Medline, PubMed and Cochrane Library were searched. Results After screening the 6,204 abstracts identified in the search, no studies meeting all eligibility criteria were found. Two partially eligible studies were identified. These met the intervention and outcomes criteria but included mixed-age cohorts that included but were not limited to women ≤40. These studies provided low-level (Level IV) evidence of moderate quality that there is some benefit (earlier stage at diagnosis and/or improved survival) of breast awareness in a mixed-age cohort that included some younger women. Conclusions No studies evaluating the impact of breast awareness exclusively in young women were identified. Limited evidence of benefit of breast awareness was found. Guidelines that recommend breast awareness should be reviewed and qualified with an explanation that the evidence of benefit is weak. Women have limited screening options available to them for the early detection of breast cancer until they reach mammographic screening age. The study was registered on Prospero (ID: CRD42021279457).