cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.21670038.v1
title: Fulminant endogenous panophthalmitis caused by Clostridium septicum infection

description: ABSTRACT We report an unusual case of fulminant endogenous Clostridium septicum panophthalmitis. A 74-year-old male patient presented with sudden amaurosis in the right eye, which in a few hours, evolved into an orbital cellulitis, endophthalmitis, anterior segment ischemia, and secondary perforation of the eye. A complete diagnostic study, which included cranial and orbital contrast-enhanced computed tomography scan, contrast-enhanced magnetic resonance imaging, blood cultures, and complete blood work, were performed. No causal agent was identified. Clostridium septicum infection caused fulminant gaseous panophthalmitis. Despite broad-spectrum antibiotic treatment, evisceration of the eyeball was necessary. The extension study showed a colon adenocarcinoma as the origin of the infection. Clostridium septicum panophthalmitis is a rare but aggressive orbital infection. This infection warrants the identification of a neoplastic process in the gastrointestinal tract in many cases not previously described.
DOI: 10.6084/m9.figshare.21670039
title: Cognitive impairment in bipolar disorder in comparison to mild cognitive impairment and dementia: a systematic review

description: Abstract Objective To conduct a systematic review to describe cognitive abilities in bipolar disorder (BD) in comparison to cognitive abilities in mild cognitive impairment (MCI) and dementia. Methods A literature search was performed with no year or language restrictions. The search yielded 1,461 articles, with 1,261 remaining after removal of duplicates, five of which were suitable for the systematic review: two for the comparison between BD and MCI and three comparing BD and dementia. Results Analyses from our systematic review showed that euthymic individuals with BD present impairments in cognitive domains such as attention and executive functioning, motor skills, conceptual thinking, and visuo-spatial abilities that are equally severe as or more severe than the impairments observed in individuals with MCI. In contrast, studies comparing BD and dementia indicated that Alzheimer’s disease (AD) dementia and behavioral variant frontotemporal dementia (bvFTD) both showed greater cognitive deficits than BD during euthymia, whereas BD during a mood episode demonstrated higher cognitive impairments than bvFTD. Conclusion Findings from our systematic review suggest that cognitive impairments in euthymic BD fall into a range between the impairments seen in MCI and those seen in dementia. More studies are needed to analyze these comparisons, while also focusing on comparing different clinical stages of BD with MCI and dementia to analyze the progression of the clinical course and cognitive dysfunction in BD.PROSPERO registration ID: CRD42020150412
DOI: 10.6084/m9.figshare.21670039.v1
title: Cognitive impairment in bipolar disorder in comparison to mild cognitive impairment and dementia: a systematic review

description: Abstract Objective To conduct a systematic review to describe cognitive abilities in bipolar disorder (BD) in comparison to cognitive abilities in mild cognitive impairment (MCI) and dementia. Methods A literature search was performed with no year or language restrictions. The search yielded 1,461 articles, with 1,261 remaining after removal of duplicates, five of which were suitable for the systematic review: two for the comparison between BD and MCI and three comparing BD and dementia. Results Analyses from our systematic review showed that euthymic individuals with BD present impairments in cognitive domains such as attention and executive functioning, motor skills, conceptual thinking, and visuo-spatial abilities that are equally severe as or more severe than the impairments observed in individuals with MCI. In contrast, studies comparing BD and dementia indicated that Alzheimer’s disease (AD) dementia and behavioral variant frontotemporal dementia (bvFTD) both showed greater cognitive deficits than BD during euthymia, whereas BD during a mood episode demonstrated higher cognitive impairments than bvFTD. Conclusion Findings from our systematic review suggest that cognitive impairments in euthymic BD fall into a range between the impairments seen in MCI and those seen in dementia. More studies are needed to analyze these comparisons, while also focusing on comparing different clinical stages of BD with MCI and dementia to analyze the progression of the clinical course and cognitive dysfunction in BD.PROSPERO registration ID: CRD42020150412
DOI: 10.6084/m9.figshare.21670041
title: Performance and Ancestral Heritage: what does Bakongo cosmology teach about black Brazilian childhood?

description: ABSTRACT Through African and Afro-diasporic references, it is proposed a reflexive exercise on Black children and their performances. Based on studies about Bantu-Kongo cosmology, an approach to Bakongo childhood is sought to provide an understanding of the performances of black Brazilian childhood, relating them to the preservation of African civilizational values. It is concluded, considering ancestral heritage and a cosmological notion of circular time, that Brazilian Black children, through performance, are able to bring together past and present, ancestral and living, renewing memory and keeping the values of Afro-Brazilian civilization alive.
DOI: 10.6084/m9.figshare.21670041.v1
title: Performance and Ancestral Heritage: what does Bakongo cosmology teach about black Brazilian childhood?

description: ABSTRACT Through African and Afro-diasporic references, it is proposed a reflexive exercise on Black children and their performances. Based on studies about Bantu-Kongo cosmology, an approach to Bakongo childhood is sought to provide an understanding of the performances of black Brazilian childhood, relating them to the preservation of African civilizational values. It is concluded, considering ancestral heritage and a cosmological notion of circular time, that Brazilian Black children, through performance, are able to bring together past and present, ancestral and living, renewing memory and keeping the values of Afro-Brazilian civilization alive.
DOI: 10.6084/m9.figshare.21670044
title: Copeau and Bing's Childhood Laboratories: a group of children, the embryo of the École du Vieux Colombier

description: ABSTRACT The article presents the results of research on the child as a model in the theatrical pedagogy from the concretization, by Jacques Copeau and Suzanne Bing, of childhood laboratories. One of these laboratories – the children’s group of the Club de Gymnastique Rythmique, which is considered as the embryo of the École du Vieux Colombier – is highlighted to emphasize the role of Bing and the importance of children’s play in Copeau’s theatrical pedagogy. It is concluded that this laboratory was extremely relevant for the pedagogical preparation of Copeau and Bing as well as for the opening of research horizons, such as mime and animal imitation, later deepened at the École du Vieux Colombier.
DOI: 10.6084/m9.figshare.21670044.v1
title: Copeau and Bing's Childhood Laboratories: a group of children, the embryo of the École du Vieux Colombier

description: ABSTRACT The article presents the results of research on the child as a model in the theatrical pedagogy from the concretization, by Jacques Copeau and Suzanne Bing, of childhood laboratories. One of these laboratories – the children’s group of the Club de Gymnastique Rythmique, which is considered as the embryo of the École du Vieux Colombier – is highlighted to emphasize the role of Bing and the importance of children’s play in Copeau’s theatrical pedagogy. It is concluded that this laboratory was extremely relevant for the pedagogical preparation of Copeau and Bing as well as for the opening of research horizons, such as mime and animal imitation, later deepened at the École du Vieux Colombier.
DOI: 10.6084/m9.figshare.21639923
title: Stress-strain distribution and failure mechanisms in dual-phase steels investigated with microstructure-based modeling

description: Abstract In this study, the microstructural-based finite element modeling of dual-phase steels was investigated to visualize the crack initiation and its propagation through the phases that exist in the material. The parameters of various failure models, including Gurson, Gurson-Johnson-Cook, and Johnson-Cook (JC), were calibrated for different microstructure levels of DP600, DP800, and DP1000 steels. The onset of cracking, nucleation, void growth, and coalescence was determined using the models. As a result of the optimization studies, there is not much difference between the flow curves of the materials and the tensile values calculated from the tensile tests for DP600 and DP800, while it is slightly higher for DP1000. However, considering the fracture, martensite phases were found to be the main determinant of this situation. Cracks that start in the martensite phases then propagate through the ferrite phase and eventually cause the material to break. According to the results of the simulations, the difference between the experiments and the simulation results of the Gurson is 3.33%, the Gurson-JC is 1.82%, and the JC model is 2.39%.
DOI: 10.6084/m9.figshare.21639923.v1
title: Stress-strain distribution and failure mechanisms in dual-phase steels investigated with microstructure-based modeling

description: Abstract In this study, the microstructural-based finite element modeling of dual-phase steels was investigated to visualize the crack initiation and its propagation through the phases that exist in the material. The parameters of various failure models, including Gurson, Gurson-Johnson-Cook, and Johnson-Cook (JC), were calibrated for different microstructure levels of DP600, DP800, and DP1000 steels. The onset of cracking, nucleation, void growth, and coalescence was determined using the models. As a result of the optimization studies, there is not much difference between the flow curves of the materials and the tensile values calculated from the tensile tests for DP600 and DP800, while it is slightly higher for DP1000. However, considering the fracture, martensite phases were found to be the main determinant of this situation. Cracks that start in the martensite phases then propagate through the ferrite phase and eventually cause the material to break. According to the results of the simulations, the difference between the experiments and the simulation results of the Gurson is 3.33%, the Gurson-JC is 1.82%, and the JC model is 2.39%.
DOI: 10.6084/m9.figshare.21670047
title: Afibercept treatment for macular edema with and without serous retinal detachment due to branch retinal vein occlusion

description: ABSTRACT Purpose: To evaluate the effectiveness of intravitreal aflibercept treatment for macular edema with and without serous retinal detachment due to branch retinal vein occlusion. Methods: Thirty-seven eyes with branch retinal vein occlusion treated with intravitreal aflibercept injection for macular edema were evaluated retrospectively. The patients were divided into two groups according to whether they showed serous retinal detachment on spectral domain optical coherence tomography. Pro re nata regimen was applied after 1 dose of intravitreal aflibercept injection. After the initial injection, control treatments were administered at months 1, 2, 3, 6, and 12. The best-corrected visual acuity and central macular thickness were measured. Results: Fifteen patients had serous retinal detachment, and 22 with macular edema only (non-serous retinal detachment). The central macular thickness was significantly greater in the group with than in the group without serous retinal detachment (811.73 ± 220.68 µm and 667.90 ± 220.68 µm, respectively, p=0.04). The difference between the groups disappeared from the third month. The central macular thickness was similar between the two groups at the last control treatment (407.27 ± 99.08 µm and 376.66 ± 74.71 µm, p=0.66). The best-corrected visual acuity increased significantly in both groups. No significant difference was found between the two groups in terms of the best-corrected visual acuities at baseline and the final control. Conclusion: The intravitreal aflibercept treatment was highly effective in improving best-corrected visual acuity and central macular thickness in patients with branch retinal vein occlusion-induced macular edema independent of serous retinal detachment.
DOI: 10.6084/m9.figshare.21670047.v1
title: Afibercept treatment for macular edema with and without serous retinal detachment due to branch retinal vein occlusion

description: ABSTRACT Purpose: To evaluate the effectiveness of intravitreal aflibercept treatment for macular edema with and without serous retinal detachment due to branch retinal vein occlusion. Methods: Thirty-seven eyes with branch retinal vein occlusion treated with intravitreal aflibercept injection for macular edema were evaluated retrospectively. The patients were divided into two groups according to whether they showed serous retinal detachment on spectral domain optical coherence tomography. Pro re nata regimen was applied after 1 dose of intravitreal aflibercept injection. After the initial injection, control treatments were administered at months 1, 2, 3, 6, and 12. The best-corrected visual acuity and central macular thickness were measured. Results: Fifteen patients had serous retinal detachment, and 22 with macular edema only (non-serous retinal detachment). The central macular thickness was significantly greater in the group with than in the group without serous retinal detachment (811.73 ± 220.68 µm and 667.90 ± 220.68 µm, respectively, p=0.04). The difference between the groups disappeared from the third month. The central macular thickness was similar between the two groups at the last control treatment (407.27 ± 99.08 µm and 376.66 ± 74.71 µm, p=0.66). The best-corrected visual acuity increased significantly in both groups. No significant difference was found between the two groups in terms of the best-corrected visual acuities at baseline and the final control. Conclusion: The intravitreal aflibercept treatment was highly effective in improving best-corrected visual acuity and central macular thickness in patients with branch retinal vein occlusion-induced macular edema independent of serous retinal detachment.
DOI: 10.6084/m9.figshare.21670050.v1
title: Progress Test for medical students: experience of a consortium in Northeastern Brazil

description: Abstract: Introduction: Collaboration between medical schools to hold the PT has expanded, constituting a model of educational practice. Experience report: The CIN 1 group of medical schools was established in 2013, organized with a general coordinator and coordinators from each participating school. It holds two tests a year, with a varying number of participant schools. The test has 120 questions distributed in 6 areas (Applied Basic Sciences, Public Health, Pediatrics, Internal Medicine, Surgery/Urgent and Emergency, Gynecology and Obstetrics) and its blueprint is based on a previously validated Matrix. The 4-hour test is applied to all students from participating schools, on the same day and at the same time. It was administered online in 2020 and 2021 due to the COVID-19 pandemic. The student’s total score is calculated by the number of correct questions, excluding the “don’t know” option, or penalties for incorrect ones, and is analyzed by classical item theory. Students receive performance analysis compared to the average attained by students in the same year, and the progression in relation to the previous test. The schools receive the performance of the respective students and analysis of the difficulty and general breakdown of the items and an overall evaluation of the test. Discussion: The implementation of CIN 1 represented a great advance for the schools involved. The collaboration was not only about the test, but also for the teacher development in a joint way. Bylaw impediments and costs may justify the variation in school participation. Conclusion: The organization of a group of schools for the TP brings benefits and many challenges. Improving analysis and feedback criteria and including students in the assessment of questions are steps to be discussed and implemented. The use of the lower cost virtual environment may facilitate increased participation of schools.
DOI: 10.6084/m9.figshare.21670050
title: Progress Test for medical students: experience of a consortium in Northeastern Brazil

description: Abstract: Introduction: Collaboration between medical schools to hold the PT has expanded, constituting a model of educational practice. Experience report: The CIN 1 group of medical schools was established in 2013, organized with a general coordinator and coordinators from each participating school. It holds two tests a year, with a varying number of participant schools. The test has 120 questions distributed in 6 areas (Applied Basic Sciences, Public Health, Pediatrics, Internal Medicine, Surgery/Urgent and Emergency, Gynecology and Obstetrics) and its blueprint is based on a previously validated Matrix. The 4-hour test is applied to all students from participating schools, on the same day and at the same time. It was administered online in 2020 and 2021 due to the COVID-19 pandemic. The student’s total score is calculated by the number of correct questions, excluding the “don’t know” option, or penalties for incorrect ones, and is analyzed by classical item theory. Students receive performance analysis compared to the average attained by students in the same year, and the progression in relation to the previous test. The schools receive the performance of the respective students and analysis of the difficulty and general breakdown of the items and an overall evaluation of the test. Discussion: The implementation of CIN 1 represented a great advance for the schools involved. The collaboration was not only about the test, but also for the teacher development in a joint way. Bylaw impediments and costs may justify the variation in school participation. Conclusion: The organization of a group of schools for the TP brings benefits and many challenges. Improving analysis and feedback criteria and including students in the assessment of questions are steps to be discussed and implemented. The use of the lower cost virtual environment may facilitate increased participation of schools.
DOI: 10.6084/m9.figshare.21670051
title: Corneal Perforation associated with “Silent Brain Syndrome”

description: ABSTRACT This case report describes the clinical characteristics and ophthalmic management of a patient who developed corneal perforation due to severe enophthalmos consistent with “silent brain syndrome.” A 27-year-old man with a history of congenital hydrocephalus and ventriculoperitoneal shunt was referred with complaints of “sinking of the eyeballs” and progressively decreasing vision in the left eye. Examination revealed severe bilateral enophthalmos in addition to superonasal corneal perforation with iris prolapse in the left eye. The patient underwent therapeutic keratoplasty the next day. Orbital reconstruction with costochondral graft and shunt revision of the intracranial hypotension were performed the next month to prevent further progression.
DOI: 10.6084/m9.figshare.21670051.v1
title: Corneal Perforation associated with “Silent Brain Syndrome”

description: ABSTRACT This case report describes the clinical characteristics and ophthalmic management of a patient who developed corneal perforation due to severe enophthalmos consistent with “silent brain syndrome.” A 27-year-old man with a history of congenital hydrocephalus and ventriculoperitoneal shunt was referred with complaints of “sinking of the eyeballs” and progressively decreasing vision in the left eye. Examination revealed severe bilateral enophthalmos in addition to superonasal corneal perforation with iris prolapse in the left eye. The patient underwent therapeutic keratoplasty the next day. Orbital reconstruction with costochondral graft and shunt revision of the intracranial hypotension were performed the next month to prevent further progression.
DOI: 10.6084/m9.figshare.21670053
title: Effects of the epiretinal membrane on the outcomes of intravitreal dexamethasone implantation for macular edema secondary to branch retinal vein occlusion

description: ABSTRACT Purpose: To investigate the effects of epiretinal membrane formation on the clinical outcomes of intravitreal dexamethasone implantation for macular edema secondary to branch retinal vein occlusion. Methods: This retrospective interventional case series includes the treatment of naive patients with macular edema secondary to non-ischemic branch retinal vein occlusion who underwent intravitreal dexamethasone implantation. The patients were divided into two groups as follows: Group 1 (n=25), comprised of patients with macular edema secondary to branch retinal vein occlusion without epiretinal membrane, and Group 2 (n=16), comprised of patients with macular edema secondary to branch retinal vein occlusion with an epiretinal membrane. Corrected visual acuity, central macular thickness, and central macular volume values were measured before and after treatment. The clinical outcomes of the groups were compared. Results: Mean age and male-to-female ratio were similar between the two groups (p&gt;0.05, for both). The baseline and final corrected visual acuity values, central macular thickness, and central macular volumes of the groups were similar (p&gt;0.05, for all). All the parameters were significantly improved after intravitreal dexamethasone implantation treatment (p&lt;0.001, for all). The changes in central macular thickness and volume were also similar (p&gt;0.05, for both). The mean number of intravitreal dexamethasone implantations was 2.1 ± 1.0 (range, 1-4) in Group 1 and 3.0 ± 1.2 (range, 1-5) in Group 2 (p=0.043). Conclusion: Epiretinal membrane formation had no effects on the baseline and final clinical parameters, including corrected visual acuity and central macular thickness and volume. The only parameter affected by the presence of epiretinal membrane formation is the number of intravitreal dexamethasone implantations, a greater number of which is needed for macular edema secondary to branch retinal vein occlusion with an epiretinal membrane.