cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.9822077
title: AR.IA App drug breakdown

description: Baseline empiric therapy recommendations for each bacteria and symptom of interest.
DOI: 10.6084/m9.figshare.9822122
title: AR.IA App economic data

description: Antibiotic cost, WHO EML and AWaRe.
DOI: 10.6084/m9.figshare.9822077.v1
title: AR.IA App drug breakdown

description: Baseline empiric therapy recommendations for each bacteria and symptom of interest.
DOI: 10.6084/m9.figshare.9822104
title: AR.IA App drug breakdown (groups)

description: Baseline empiric therapy recommendations with drug groupings instead of individual drugs.
DOI: 10.6084/m9.figshare.9822122.v1
title: AR.IA App economic data

description: Antibiotic cost, WHO EML and AWaRe.
DOI: 10.6084/m9.figshare.9821783
title: Spiller et al Raw Data from Exploring the relationship between grapheme colour-picking consistency and mental imagery

description: Full data set used in analysis by Spiller et al
DOI: 10.6084/m9.figshare.9821996
title: AR.IA App all datasets

description: Data from the ATLAS dataset, the ECDC Surveillance Atlas, ResistanceMap, and GLASS aggregated by species and drugs of interest in our analysis.
DOI: 10.6084/m9.figshare.9822104.v1
title: AR.IA App drug breakdown (groups)

description: Baseline empiric therapy recommendations with drug groupings instead of individual drugs.
DOI: 10.6084/m9.figshare.9821774
title: Behavioral and ERP data for statistical analysis from How non-veridical perception drives actions in healthy humans: evidence from synaesthesia

description: We continually perform actions that are driven by our perception and it is a commonly held view that only objectively perceived changes within the ‘real’ world affect behaviour. Exceptions are generally only made for mental health disorders associated with delusions and hallucinations where behaviour may be triggered by the experience of objectively non-existent percepts. Here, we demonstrate, using synaesthesia as a model condition (in <i>N</i> = 19 grapheme–colour synaesthetes), how objectively non-existent (i.e. non-veridical) but still non-pathological perceptions affect actions in healthy humans. Using electroencephalography, we determine whether early-stage perceptual processes (reflected by P1 and N1 event-related potential (ERP) components), or late stage-integration processes (reflected by N2 component), underlie the effects of non-veridical perceptions on action control. ERP analysis suggests that even though the examined peculiarities and experimental variations are perceptual in nature, it is not early-stage perceptual processes, but rather higher-order executive control processes linking perceptions to the appropriate motor response underlying this effect. Source localization analysis implicates activation within medial frontal cortices in the effect of how irrelevant non-veridical perceptions modulate behaviour. Our results challenge common conceptions about the determinants of human behaviour but can be explained by well-established theoretical frameworks detailing the link between perception and action.This article is part of the discussion meeting issue ‘Bridging senses: new developments in synaesthesia’.
DOI: 10.6084/m9.figshare.9821777
title: Source code for the experimental paradigm from How non-veridical perception drives actions in healthy humans: evidence from synaesthesia

description: We continually perform actions that are driven by our perception and it is a commonly held view that only objectively perceived changes within the ‘real’ world affect behaviour. Exceptions are generally only made for mental health disorders associated with delusions and hallucinations where behaviour may be triggered by the experience of objectively non-existent percepts. Here, we demonstrate, using synaesthesia as a model condition (in <i>N</i> = 19 grapheme–colour synaesthetes), how objectively non-existent (i.e. non-veridical) but still non-pathological perceptions affect actions in healthy humans. Using electroencephalography, we determine whether early-stage perceptual processes (reflected by P1 and N1 event-related potential (ERP) components), or late stage-integration processes (reflected by N2 component), underlie the effects of non-veridical perceptions on action control. ERP analysis suggests that even though the examined peculiarities and experimental variations are perceptual in nature, it is not early-stage perceptual processes, but rather higher-order executive control processes linking perceptions to the appropriate motor response underlying this effect. Source localization analysis implicates activation within medial frontal cortices in the effect of how irrelevant non-veridical perceptions modulate behaviour. Our results challenge common conceptions about the determinants of human behaviour but can be explained by well-established theoretical frameworks detailing the link between perception and action.This article is part of the discussion meeting issue ‘Bridging senses: new developments in synaesthesia’.
DOI: 10.6084/m9.figshare.9821783.v1
title: Spiller et al Raw Data from Exploring the relationship between grapheme colour-picking consistency and mental imagery

description: Full data set used in analysis by Spiller et al
DOI: 10.6084/m9.figshare.9821996.v1
title: AR.IA App all datasets

description: Data from the ATLAS dataset, the ECDC Surveillance Atlas, ResistanceMap, and GLASS aggregated by species and drugs of interest in our analysis.
DOI: 10.6084/m9.figshare.9821774.v1
title: Behavioral and ERP data for statistical analysis from How non-veridical perception drives actions in healthy humans: evidence from synaesthesia

description: We continually perform actions that are driven by our perception and it is a commonly held view that only objectively perceived changes within the ‘real’ world affect behaviour. Exceptions are generally only made for mental health disorders associated with delusions and hallucinations where behaviour may be triggered by the experience of objectively non-existent percepts. Here, we demonstrate, using synaesthesia as a model condition (in <i>N</i> = 19 grapheme–colour synaesthetes), how objectively non-existent (i.e. non-veridical) but still non-pathological perceptions affect actions in healthy humans. Using electroencephalography, we determine whether early-stage perceptual processes (reflected by P1 and N1 event-related potential (ERP) components), or late stage-integration processes (reflected by N2 component), underlie the effects of non-veridical perceptions on action control. ERP analysis suggests that even though the examined peculiarities and experimental variations are perceptual in nature, it is not early-stage perceptual processes, but rather higher-order executive control processes linking perceptions to the appropriate motor response underlying this effect. Source localization analysis implicates activation within medial frontal cortices in the effect of how irrelevant non-veridical perceptions modulate behaviour. Our results challenge common conceptions about the determinants of human behaviour but can be explained by well-established theoretical frameworks detailing the link between perception and action.This article is part of the discussion meeting issue ‘Bridging senses: new developments in synaesthesia’.
DOI: 10.6084/m9.figshare.9821762
title: Dataset from Phenotypic integration and modularity drives skull shape divergence in the Arctic fox (<i>Vulpes lagopus</i>) from the Commander islands

description: Phenotypic integration and modularity influence morphological disparity and evolvability. However, studies addressing how morphological integration and modularity change for long periods of genetic isolation are scarce. Here, we investigate patterns of phenotypic integration and modularity in the skull of phenotypically and genetically distinct populations of the Artic fox (<i>Vulpes lagopus</i>) from the Commander islands of the Aleutian belt (i.e. Bering and Mednyi) that were isolated <i>ca</i> 10 000 years by ice-free waters of the Bering sea. We use three-dimensional geometric morphometrics to quantify the strength of modularity and integration from inter-individual variation (static) and from fluctuating asymmetry (random developmental variation) in both island populations compared to the mainland population (i.e. Chukotka) and we investigated how changes in morphological integration and modularity affect the directionality of disparity trait divergence. Our results indicate a decrease in morphological integration concomitant to an increase in disparity at a developmental level, from mainland to the smallest and farthest population of Mednyi. However, phenotypic integration is higher in both island populations accompanied by a reduction in disparity compared to the population of mainland at a static level. This higher integration may have favoured morphological adaptive changes towards specific feeding behaviours related to the extreme environmental settings of islands. Our study demonstrates how shifts in phenotypic integration and modularity can facilitate phenotypic evolvability at intraspecific level that may lead to lineage divergence at macroevolutioanry scales.
DOI: 10.6084/m9.figshare.9821777.v1
title: Source code for the experimental paradigm from How non-veridical perception drives actions in healthy humans: evidence from synaesthesia

description: We continually perform actions that are driven by our perception and it is a commonly held view that only objectively perceived changes within the ‘real’ world affect behaviour. Exceptions are generally only made for mental health disorders associated with delusions and hallucinations where behaviour may be triggered by the experience of objectively non-existent percepts. Here, we demonstrate, using synaesthesia as a model condition (in <i>N</i> = 19 grapheme–colour synaesthetes), how objectively non-existent (i.e. non-veridical) but still non-pathological perceptions affect actions in healthy humans. Using electroencephalography, we determine whether early-stage perceptual processes (reflected by P1 and N1 event-related potential (ERP) components), or late stage-integration processes (reflected by N2 component), underlie the effects of non-veridical perceptions on action control. ERP analysis suggests that even though the examined peculiarities and experimental variations are perceptual in nature, it is not early-stage perceptual processes, but rather higher-order executive control processes linking perceptions to the appropriate motor response underlying this effect. Source localization analysis implicates activation within medial frontal cortices in the effect of how irrelevant non-veridical perceptions modulate behaviour. Our results challenge common conceptions about the determinants of human behaviour but can be explained by well-established theoretical frameworks detailing the link between perception and action.This article is part of the discussion meeting issue ‘Bridging senses: new developments in synaesthesia’.
DOI: 10.6084/m9.figshare.9821762.v1
title: Dataset from Phenotypic integration and modularity drives skull shape divergence in the Arctic fox (<i>Vulpes lagopus</i>) from the Commander islands

description: Phenotypic integration and modularity influence morphological disparity and evolvability. However, studies addressing how morphological integration and modularity change for long periods of genetic isolation are scarce. Here, we investigate patterns of phenotypic integration and modularity in the skull of phenotypically and genetically distinct populations of the Artic fox (<i>Vulpes lagopus</i>) from the Commander islands of the Aleutian belt (i.e. Bering and Mednyi) that were isolated <i>ca</i> 10 000 years by ice-free waters of the Bering sea. We use three-dimensional geometric morphometrics to quantify the strength of modularity and integration from inter-individual variation (static) and from fluctuating asymmetry (random developmental variation) in both island populations compared to the mainland population (i.e. Chukotka) and we investigated how changes in morphological integration and modularity affect the directionality of disparity trait divergence. Our results indicate a decrease in morphological integration concomitant to an increase in disparity at a developmental level, from mainland to the smallest and farthest population of Mednyi. However, phenotypic integration is higher in both island populations accompanied by a reduction in disparity compared to the population of mainland at a static level. This higher integration may have favoured morphological adaptive changes towards specific feeding behaviours related to the extreme environmental settings of islands. Our study demonstrates how shifts in phenotypic integration and modularity can facilitate phenotypic evolvability at intraspecific level that may lead to lineage divergence at macroevolutioanry scales.
DOI: 10.6084/m9.figshare.9821621
title: Supplementary Material for: Respiratory Sinus Arrhythmia Attenuation via Targeted Lung Denervation in Sheep and Humans

description: <b><i>Background:</i></b> Targeted lung denervation (TLD) is a novel bronchoscopic therapy that disrupts parasympathetic pulmonary nerve input to the lung. Parasympathetic input to the heart originating from the lungs contributes to respiratory sinus arrhythmia (RSA) and disruption of pulmonary nerves via TLD may impact RSA. <b><i>Objective:</i></b> The aim of this study was to assess the potential of TLD to affect RSA in sheep and humans. <b><i>Methods:</i></b> TLD was performed in 5 sheep and 9 humans using a novel lung denervation system (Nu­vaira Inc., Minneapolis, MN, USA) with an electrocardiogram collected before and after the procedure. Frequency domain analysis of heart rate variability was performed in 5 sheep and 6 humans with presence of RSA approximated as high-frequency power (HF power). <b><i>Results:</i></b> HF power decreased in 3 of 5 sheep with 1 animal reaching less than 7% of its baseline HF power 30 days after TLD. The average treatment location was more distal in the remaining 2 animals, which did not exhibit RSA attenuation, suggesting diminished denervation. HF power decreased in 5 of 6 humans, with 3 subjects reaching less than 50% of their baseline HF power 90 days after TLD. <b><i>Conclusions:</i></b> TLD appeared to attenuate RSA in both sheep and human cohorts of this sub-study. Further confirmation in humans is necessary to allow for RSA attenuation to be used as a marker of successful lung denervation via TLD.
DOI: 10.6084/m9.figshare.9821528
title: Supplementary Material for: Metformin and Aging: A Review

description: Metformin is sometimes proposed to be an “anti-aging” drug, based on preclinical experiments with lower-order organisms and numerous retrospective data on beneficial health outcomes for type 2 diabetics. Large prospective, placebo-controlled trials are planned, in pilot stage or running, to find a new use (or indication) for an aging population. As one of the metformin trials has “frailty” as its endpoint, similar to a trial with a plant-derived senolytic, the latter class of novel anti-aging drugs is briefly discussed. Concerns exist not only for vitamin B<sub>12</sub> and B<sub>6</sub> deficiencies, but also about whether there are adverse effects of metformin on individuals who try to remain healthy by maintaining cardiovascular fitness via exercise.
DOI: 10.6084/m9.figshare.9821528.v1
title: Supplementary Material for: Metformin and Aging: A Review

description: Metformin is sometimes proposed to be an “anti-aging” drug, based on preclinical experiments with lower-order organisms and numerous retrospective data on beneficial health outcomes for type 2 diabetics. Large prospective, placebo-controlled trials are planned, in pilot stage or running, to find a new use (or indication) for an aging population. As one of the metformin trials has “frailty” as its endpoint, similar to a trial with a plant-derived senolytic, the latter class of novel anti-aging drugs is briefly discussed. Concerns exist not only for vitamin B<sub>12</sub> and B<sub>6</sub> deficiencies, but also about whether there are adverse effects of metformin on individuals who try to remain healthy by maintaining cardiovascular fitness via exercise.
DOI: 10.6084/m9.figshare.9821621.v1
title: Supplementary Material for: Respiratory Sinus Arrhythmia Attenuation via Targeted Lung Denervation in Sheep and Humans

description: <b><i>Background:</i></b> Targeted lung denervation (TLD) is a novel bronchoscopic therapy that disrupts parasympathetic pulmonary nerve input to the lung. Parasympathetic input to the heart originating from the lungs contributes to respiratory sinus arrhythmia (RSA) and disruption of pulmonary nerves via TLD may impact RSA. <b><i>Objective:</i></b> The aim of this study was to assess the potential of TLD to affect RSA in sheep and humans. <b><i>Methods:</i></b> TLD was performed in 5 sheep and 9 humans using a novel lung denervation system (Nu­vaira Inc., Minneapolis, MN, USA) with an electrocardiogram collected before and after the procedure. Frequency domain analysis of heart rate variability was performed in 5 sheep and 6 humans with presence of RSA approximated as high-frequency power (HF power). <b><i>Results:</i></b> HF power decreased in 3 of 5 sheep with 1 animal reaching less than 7% of its baseline HF power 30 days after TLD. The average treatment location was more distal in the remaining 2 animals, which did not exhibit RSA attenuation, suggesting diminished denervation. HF power decreased in 5 of 6 humans, with 3 subjects reaching less than 50% of their baseline HF power 90 days after TLD. <b><i>Conclusions:</i></b> TLD appeared to attenuate RSA in both sheep and human cohorts of this sub-study. Further confirmation in humans is necessary to allow for RSA attenuation to be used as a marker of successful lung denervation via TLD.
DOI: 10.6084/m9.figshare.9821342
title: Supplementary Material for: Lifestyle Interventions for Weight Management in People with Serious Mental Illness: A Systematic Review with Meta-Analysis, Trial Sequential Analysis, and Meta-Regression Analysis Exploring the Mediators and Moderators of Treatment Effects

description: <b><i>Background:</i></b> Serious mental illness (SMI) reduces life expectancy, primarily due to somatic comorbidity linked to obesity. Meta-analyses have found beneficial effects of lifestyle interventions in people with SMI and recommended their implementation to manage obesity. <b><i>Objective:</i></b> The objective of this systematic review was to assess the benefits and harms of individualized lifestyle interventions for weight in people diagnosed with SMI and to explore potential mediators and moderators of the effect. <b><i>Methods:</i></b> The protocol was registered at PROSPERO (CRD42016049093). Randomized clinical trials (RCTs) assessing the effect of individualized lifestyle interventions on weight management in people with SMI were included. Primary outcomes were differences in endpoint body mass index (BMI) and the proportion achieving clinically relevant weight loss (≥5%). Secondary outcomes included quality of life, cardiometabolic risk factors, and adverse effects. <b><i>Results:</i></b> We included 41 RCTs (<i>n</i> = 4,267). All trials were at high risk of bias according to the Cochrane Handbook for Systematic Reviews of Interventions. The experimental interventions reduced the mean difference in BMI by –0.63 kg/m<sup>2</sup> (95% confidence interval [CI] = –1.02 to –0.23; <i>p</i> = 0.002; <i>I</i><sup>2</sup> = 70.7%) compared to the control groups. At postintervention follow-up (17 RCTs), the effect size remained similar but was no longer significant (BMI = –0.63 kg/m<sup>2</sup>; 95% CI = –1.30 to 0.04; <i>p</i> = 0.07; <i>I</i><sup>2</sup> = 48.8%). The risk ratio for losing ≥5% of baseline weight was 1.51 (95% CI = 1.07–2.13; <i>p</i> = 0.02) compared to the control groups. GRADE showed very low or low quality of evidence. <b><i>Conclusion:</i></b> There is a statistically significant, but clinically insignificant, mean effect of individualized lifestyle interventions for weight reduction in people with SMI.
DOI: 10.6084/m9.figshare.9821279
title: Supplementary Material for: Yes-Associated Protein Promotes the Development of Condyloma Acuminatum through EGFR Pathway Activation

description: <b><i>Objective:</i></b> Investigate the role of Yes-associated protein (YAP1) in the development of condyloma acuminatum (CA). <b><i>Methods:</i></b> We enrolled 30 male patients with CA and 20 healthy individuals as a control group, to compare the YAP1 expression in their tissue samples. Following this, we overexpressed and downregulated <i>YAP1</i> expression in HaCaT cells to examine the migratory, proliferative, and apoptotic potential of HaCaT cells expressing different levels of YAP1. <b><i>Results:</i></b> In the CA patient tissue samples, an increase in YAP1 expression can be observed. In vitro<i>,</i>the overexpression of YAP1 was shown to promote the growth and migration of HaCaT cells and to activate epidermal growth factor receptor (EGFR) pathway-associated proteins, while the downregulation of YAP1 inhibited cell growth and migration of these cells. <b><i>Conclusions:</i></b> YAP1 promotes the growth of keratinocytes in CA through the activation of the EGFR pathway, and it may mediate the development of human papilloma virus-associated diseases.
DOI: 10.6084/m9.figshare.9821222
title: Quantitative structure-activity relationship and molecular docking studies on human proteasome inhibitors for anticancer activity targeting NF-κB signaling pathway

description: The abnormal ubiquitin-proteasome is found as an important target in various human diseases, especially in cancer, and recently it has received prevalent attention as a challenging therapeutic target. The current work is designed to derive a predictive two-dimensional quantitative structure-activity relationship model for anticancer human proteasome target of NF-κB signaling pathway. The established 2 D-QSAR is dependent on multiple linear regression approach and validated through leave-One-Out and external test set prediction method. The robust QSAR model showed the r<sup>2</sup> of 0.83 and q<sup>2</sup> of 0.80 and pred_r<sup>2</sup> of 0.77. Three chemical properties, electronegativity count, average potential, and T_2_N_6 were identified as significant descriptors to predict the anticancer activities of the proteasome antagonists. Besides, the predicted top hit compounds were considered to check out the compliance with Rule of five and pharmacokinetic parameters for oral bioavailability in the human body. The molecular docking was accomplished to unravel the molecular mode of action of best-predicted compounds which was compatible with the standard drug. Following this approach, lastly two compounds NP and AP were recognized as the best candidates since these top compounds follow all the standard limit point of entire filters and indicated effective and decent docking score. The outcomes of the study sturdily suggested that the developed model and top hit compound’s binding conformation are rational in the exploration of unknown antagonist’s anticancer activity. The research would be of great support and is supposed to be of immense significance in the development and designing of drug-like candidates in preliminary drug discovery. Communicated by Ramaswamy H. Sarma