cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.17632/hdhdryf7ct.1
title: Antisense oligonucleotide targeting macrophage migration inhibitory factor ameliorates experimental autoimmune encephalomyelitis

description: The file contains values underlying all graphs in figures and behind any reported means for the article titled "Antisense oligonucleotide targeting macrophage migration inhibitory factor ameliorates experimental autoimmune encephalomyelitis."

The cover and abstract of article is as follows:
Antisense oligonucleotide targeting macrophage migration inhibitory factor ameliorates experimental autoimmune encephalomyelitis

Benyuan Zhang1, 2, Sang-Hyeon Ju3, Minsung Park3, Min Hee Lee4, Hyun Jung Hong3, Jung Tae Kim3, Dong Yun Lee3, Jaehun Kim3, Ju Hee Lee1, 2, 5, Jiebo Zhu2, Jun Young Heo2, Yunju Jo6, Dongryeol Ryu6, Jinkuk Kim3, Hyon-Seung Yi1, 2, 5,**, Minho Shong3, 4, 7*

1Research Center for Endocrine and Metabolic Diseases, Chungnam National University School of Medicine, Daejeon 35015, Republic of Korea
2Department of Medical Science, Chungnam National University School of Medicine, Daejeon 35015, Republic of Korea
3Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon 34141, Republic of Korea
4THOR Therapeutics, Inc., Korea Advanced Institute of Science and Technology, Daejeon 34141, Republic of Korea
5Department of Internal Medicine, Chungnam National University Hospital, Daejeon 35015, Republic of Korea
6Department of Biomedical Science and Engineering, Gwangju Institute of Science and Technology, Gwangju 61005, Republic of Korea
7Lead contact

SUMMARY
Multiple sclerosis (MS) is a chronic, debilitating disease of the central nervous system (CNS), characterized by demyelination and axonal damage. This research investigates the role of macrophage migration inhibitory factor (MIF) in MS pathogenesis, focusing on the development and therapeutic potential of antisense oligonucleotides (ASOs) targeting MIF. Transcriptomic analysis of MS patients highlighted increased expression of MIF and its receptor CD74 in CNS lesions. In response, MIF-specific ASOs were designed and shown to effectively reduce MIF levels in vitro and in vivo. The study utilized the experimental autoimmune encephalomyelitis (EAE) mouse model, where intracerebroventricular administration of these ASOs led to significant reductions in demyelination and immune cell infiltration, while also improving motor functions. These findings suggest that targeting MIF with ASOs could be a viable treatment strategy for reducing both inflammation and neurodegeneration in MS.

Keywords: Macrophage migration inhibitory factor, antisense oligonucleotide, experimental autoimmune encephalomyelitis, multiple sclerosis, CNS inflammation
DOI: 10.17632/29kyw5w5sv.1
title: Observations in the East China Sea inner shelf in 2021 and 2022

description: Two cruises were conducted to investigate hypoxia in 2020 over the East China Sea inner shelf in August of 2021 (normal year) and 2022 (drought year) respectively. Water samples from surface layer (2m)、bottom layer (2m above the sea floor) and other 0 to 4 mid-layers were collected using a 10 L Rosette hydrophore fitted with a Sea-Bird 917 conductivity-temperature-depth (CTD) recorder. Biogeochemical data (POC, 13C, Chl-a, etc.) were measured using instruments presented in Metadata file.
DOI: 10.7266/nf2xd45p
title: Macroinvertebrate community structure data for the Deepwater Horizon oil spill sampling in the Gulf of Mexico deep-sea benthos aboard the R/V Weatherbird from 2015-08-16 to 2017-12-05
DOI: 10.48597/tnez-95br
title: Measurement of OC/EC at Ispra

description: Measurement of OC/EC at Ispra
DOI: 10.5281/zenodo.10553881
title: Data from NASA project to study ice-cemented ground in and around University Valley Antarctica

description: Data set associated with Marinova, M.M., McKay, C.P., Heldmann, J.L., Goordial, J., Lacelle, D., Pollard, W.H. and Davila, A.F., 2022. Climate and energy balance of the ground in University Valley, Antarctica. Antarctic Science, 34(2), pp.144-171. https://doi.org/10.1017/S0954102022000025
DOI: 10.5281/zenodo.10553882
title: Data from NASA project to study ice-cemented ground in and around University Valley Antarctica

description: Data set associated with Marinova, M.M., McKay, C.P., Heldmann, J.L., Goordial, J., Lacelle, D., Pollard, W.H. and Davila, A.F., 2022. Climate and energy balance of the ground in University Valley, Antarctica. Antarctic Science, 34(2), pp.144-171. https://doi.org/10.1017/S0954102022000025
DOI: 10.17632/5z5d8pkz4v.1
title: Source data

description: Source data for Western Blot
DOI: 10.17632/ftwszf2zmx.1
title: raw data

description: All experimental results
DOI: 10.5281/zenodo.13370946
title: A working collection of materials for developing ASR for Newar

description: This is a collection of video files, audio files, Elan files, etc. they were collected to train a Newar ASR (automatic speech recognition) model.
DOI: 10.5281/zenodo.13370947
title: A working collection of materials for developing ASR for Newar

description: This is a collection of video files, audio files, Elan files, etc. they were collected to train a Newar ASR (automatic speech recognition) model.
DOI: 10.26030/ngfc-7v86
title: Impact of Antiorthostatic Suspension on Mouse response to Tetanus Toxoid and CpG

description: These data were generated from mice that were skeletally unloaded using antiorthostatic suspension (AOS). Mice were either subjected to AOS or tail restraint without unloading for two weeks before injection with saline±tetanus toxoid±Cpg. Mice were unloaded for an additional two weeks before being sacrificed.
DOI: 10.5281/zenodo.13381656
title: Hyper-Reactive Malarial Splenomegaly among Febrile and Non-Febrile under Ten Children in some Selected Hospitals in South West, Nigeria

description: Hyper-reactive malarial splenomegaly (HMS) is a significant complication of chronic malaria, particularly in endemic regions. This study aimed to assess the prevalence and associated clinical parameters of HMS among febrile and non-febrile children under ten years of age in selected hospitals in South West, Nigeria. A cross-sectional study was conducted from September to October 2020 in Ifako General Hospital, Lagos State, and State Hospital Ota, Ogun State. A total of 130 children under ten years of age were recruited, with informed consent obtained from their parents. Venous blood samples were collected and analyzed for anti-malarial antibodies using Enzyme-linked Immunosorbent Assay (ELISA), malaria parasite detection via Rapid Diagnostic Test (RDT) and blood film examination, and complete blood count (CBC) using an auto-analyzer. A total of one hundred and thirty (130) questionnaires were administered to respondents and they were all retrieved. Out of the 130 questionnaires administered, only 88 were valid. This was due to irregular, incomplete and inappropriate responses to some questionnaires. Out of these, 9.1% were diagnosed with HMS. The study found significant associations between HMS and abnormal packed cell volume (PCV) (p = 0.023), white blood cell count (WBC) (p = 0.000), and body temperature (p = 0.009). The majority of children with HMS had abnormal WBC counts (87.5%) and low PCV levels (100%). Malaria parasites were detected in 90.9% of the participants, with the prevalence being higher among children with HMS. The study also observed no significant association between HMS and platelet count or lymphocyte levels. The study highlights a notable prevalence of HMS among children in South West Nigeria, with significant associations between HMS and certain hematological parameters. These findings underscore the need for enhanced malaria control efforts and early diagnosis to prevent HMS and related complications.
DOI: 10.5281/zenodo.13381657
title: Hyper-Reactive Malarial Splenomegaly among Febrile and Non-Febrile under Ten Children in some Selected Hospitals in South West, Nigeria

description: Hyper-reactive malarial splenomegaly (HMS) is a significant complication of chronic malaria, particularly in endemic regions. This study aimed to assess the prevalence and associated clinical parameters of HMS among febrile and non-febrile children under ten years of age in selected hospitals in South West, Nigeria. A cross-sectional study was conducted from September to October 2020 in Ifako General Hospital, Lagos State, and State Hospital Ota, Ogun State. A total of 130 children under ten years of age were recruited, with informed consent obtained from their parents. Venous blood samples were collected and analyzed for anti-malarial antibodies using Enzyme-linked Immunosorbent Assay (ELISA), malaria parasite detection via Rapid Diagnostic Test (RDT) and blood film examination, and complete blood count (CBC) using an auto-analyzer. A total of one hundred and thirty (130) questionnaires were administered to respondents and they were all retrieved. Out of the 130 questionnaires administered, only 88 were valid. This was due to irregular, incomplete and inappropriate responses to some questionnaires. Out of these, 9.1% were diagnosed with HMS. The study found significant associations between HMS and abnormal packed cell volume (PCV) (p = 0.023), white blood cell count (WBC) (p = 0.000), and body temperature (p = 0.009). The majority of children with HMS had abnormal WBC counts (87.5%) and low PCV levels (100%). Malaria parasites were detected in 90.9% of the participants, with the prevalence being higher among children with HMS. The study also observed no significant association between HMS and platelet count or lymphocyte levels. The study highlights a notable prevalence of HMS among children in South West Nigeria, with significant associations between HMS and certain hematological parameters. These findings underscore the need for enhanced malaria control efforts and early diagnosis to prevent HMS and related complications.
DOI: 10.15468/dl.4nwgng
title: Occurrence Download

description: A dataset containing 14495658 species occurrences available in GBIF matching the query:
{
 "and" : [
 "GadmGid is USA.44_1",
 "OccurrenceStatus is Present",
 "Year 1000-2013"
 ]
}

 The dataset includes 14495658 records from 947 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0105356-240626123714530/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.rdkt6h
title: Occurrence Download

description: A dataset containing 6353 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is one of (Norway, Sweden, Ukraine, Czechia, Slovakia, Switzerland, Spain)",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 "TaxonKey is Sphagnum palustre L."
 ]
}

 The dataset includes 6353 records from 47 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0075485-240321170329656/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.gp7ebj
title: Occurrence Download

description: A dataset containing 4 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Pleiotaxis angolensis Rodr.Oubiña & S.Ortiz"
 ]
}

 The dataset includes 4 records from 3 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0075486-240321170329656/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.3pqvy5
title: Occurrence Download

description: A dataset containing 173 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Polycardia libera O.Hoffm."
 ]
}

 The dataset includes 173 records from 22 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0075487-240321170329656/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.4v8746
title: Occurrence Download

description: A dataset containing 1 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Phoebe siamensis Kosterm."
 ]
}

 The dataset includes 1 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0075488-240321170329656/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.mpb2z9
title: Occurrence Download

description: A dataset containing 13 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Phyllocyclus petelotii (Merr.) Thiv"
 ]
}

 The dataset includes 13 records from 5 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0075489-240321170329656/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.ncb4t4
title: Occurrence Download

description: A dataset containing 2 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Pleiotaxis angusterugosa C.Jeffrey"
 ]
}

 The dataset includes 2 records from 2 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0075490-240321170329656/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.xqs85f
title: Occurrence Download

description: A dataset containing 1775 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Plantago amplexicaulis Cav."
 ]
}

 The dataset includes 1775 records from 103 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0075491-240321170329656/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.uu5ws4
title: Occurrence Download

description: A dataset containing 267 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Polycardia phyllanthoides (Lam.) DC."
 ]
}

 The dataset includes 267 records from 11 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0075492-240321170329656/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.df7pqg
title: Occurrence Download

description: A dataset containing 104 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Phoebe sterculioides (Elmer) Merr."
 ]
}

 The dataset includes 104 records from 17 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0075493-240321170329656/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.yr53my
title: Occurrence Download

description: A dataset containing 468 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Phyllodium elegans (Lour.) Desv."
 ]
}

 The dataset includes 468 records from 31 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0075494-240321170329656/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.68cbd6
title: Occurrence Download

description: A dataset containing 75 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Pleiotaxis antunesii O.Hoffm."
 ]
}

 The dataset includes 75 records from 13 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0075495-240321170329656/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.7axwsb
title: Occurrence Download

description: A dataset containing 2 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Plantago anatolica Tutel & R.R.Mill"
 ]
}

 The dataset includes 2 records from 2 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0075497-240321170329656/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.m7xg5f
title: Occurrence Download

description: A dataset containing 26 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Polycarena aemulans Hilliard"
 ]
}

 The dataset includes 26 records from 6 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0075496-240321170329656/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.xcaj2p
title: Occurrence Download

description: A dataset containing 348 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Phoebe tavoyana (Meisn.) Hook.fil."
 ]
}

 The dataset includes 348 records from 26 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0075498-240321170329656/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.3eag47
title: Occurrence Download

description: A dataset containing 15639 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is one of (Norway, Sweden, Ukraine, Czechia, Slovakia, Switzerland, Spain)",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 "TaxonKey is Sphagnum papillosum Lindb."
 ]
}

 The dataset includes 15639 records from 43 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0075499-240321170329656/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.cxztd4
title: Occurrence Download

description: A dataset containing 22 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Phyllodium insigne Schindl."
 ]
}

 The dataset includes 22 records from 7 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0075501-240321170329656/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.nmhmtu
title: Occurrence Download

description: A dataset containing 3 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Pleiotaxis bampsiana Lisowski"
 ]
}

 The dataset includes 3 records from 2 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0075500-240321170329656/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.fennmx
title: Occurrence Download

description: A dataset containing 4 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Plantago annua Ryding"
 ]
}

 The dataset includes 4 records from 4 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0075502-240321170329656/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.kgbsks
title: Occurrence Download

description: A dataset containing 85 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Polycarena aurea Benth."
 ]
}

 The dataset includes 85 records from 17 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0075503-240321170329656/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.yacj7y
title: Occurrence Download

description: A dataset containing 2 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Phoebe tenuifolia Kosterm."
 ]
}

 The dataset includes 2 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0075504-240321170329656/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.s45wkw
title: Occurrence Download

description: A dataset containing 82 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Phyllodium kurzianum (Kuntze) H.Ohashi"
 ]
}

 The dataset includes 82 records from 17 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0075505-240321170329656/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.umb554
title: Occurrence Download

description: A dataset containing 70 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Pleiotaxis chlorolepis C.Jeffrey"
 ]
}

 The dataset includes 70 records from 16 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0075506-240321170329656/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.q9hn9q
title: Occurrence Download

description: A dataset containing 83 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Plantago arachnoidea Schrenk"
 ]
}

 The dataset includes 83 records from 11 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0075507-240321170329656/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.u5dt6g
title: Occurrence Download

description: A dataset containing 20 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Polycarena batteniana Hilliard"
 ]
}

 The dataset includes 20 records from 7 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0075508-240321170329656/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.3bx4xt
title: Occurrence Download

description: A dataset containing 81 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Phoebe wightii Meisn."
 ]
}

 The dataset includes 81 records from 10 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0075509-240321170329656/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.4ufn4a
title: Occurrence Download

description: A dataset containing 7 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Pleiotaxis decipiens C.Jeffrey"
 ]
}

 The dataset includes 7 records from 3 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0075512-240321170329656/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.geftqt
title: Occurrence Download

description: A dataset containing 170 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Phyllodium longipes (Craib) Schindl."
 ]
}

 The dataset includes 170 records from 28 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0075511-240321170329656/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.zxfuk2
title: Occurrence Download

description: A dataset containing 139 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Polycarena capensis (L.) Benth."
 ]
}

 The dataset includes 139 records from 24 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0075514-240321170329656/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.