cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.15131/shef.data.9751907.v2
title: Data.Rda for How uncertain is the survival extrapolation? A study of the impact of different parametric survival models on extrapolated uncertainty about hazard functions, lifetime mean survival and cost-effectiveness

description: An R Rda-file containing the four hypothetical datasets used in the analysis (Flat, increasing, decreasing, unimodal). These are stored in a single data-frame, where the 400 rows correspond to observations. For each dataset there are three variables: an event indicator = 1 for if death was during follow-up, else = 0 (suffix "_dead"), the true time of death (suffix "_time") and the observed follow-up time, which will = 1 if the true time of death &gt; 1 (suffix "_obs"). Hence there are twelve columns.<br>A script is provided seperately within this project (Analysis.R) which includes the code used to analyse this dataset in order to obtain the results reported in the manuscript "How uncertain is the survival extrapolation? A study of the impact of different parametric survival models on extrapolated uncertainty about hazard functions, lifetime mean survival and cost-effectiveness."
DOI: 10.6084/m9.figshare.9751898
title: FLG genotyping results

description: FLG genotyping using KASP technology - results from LGC genomics
DOI: 10.15131/shef.data.9751907.v1
title: Data.Rda

description: An R Rda-file containing the four hypothetical datasets used in the analysis (Flat, increasing, decreasing, unimodal). These are stored in a single data-frame, where the 400 rows correspond to observations. For each dataset there are three variables: an event indicator = 1 for if death was during follow-up, else = 0 (suffix "_dead"), the true time of death (suffix "_time") and the observed follow-up time, which will = 1 if the true time of death &gt; 1 (suffix "_obs"). Hence there are twelve columns.<br>A script is provided seperately within this project (Analysis.R) which includes the code used to analyse this dataset in order to obtain the results reported in the manuscript "How uncertain is the survival extrapolation? A study of the impact of different parametric survival models on extrapolated uncertainty about hazard functions, lifetime mean survival and cost-effectiveness."
DOI: 10.6084/m9.figshare.9751892
title: Metadata record for: Longitudinal RNA-Seq analysis of acute and chronic neurogenic skeletal muscle atrophy

description: This dataset contains key characteristics about the data described in the Data Descriptor Longitudinal RNA-Seq analysis of acute and chronic neurogenic skeletal muscle atrophy. <br> Contents: <br> 1. human readable metadata summary table in CSV format 2. machine readable metadata file in JSON format<br><br>Versioning Note:Version 2 was generated when the metadata format was updated from JSON to JSON-LD. This was an automatic process that changed only the format, not the contents, of the metadata.<br>
DOI: 10.6084/m9.figshare.9751895
title: Supplementary Material for: Prognostic Value of Cysteine-Rich Protein 61 Combined with N-Terminal Pro-B-Type Natriuretic Peptide for Mortality in Acute Heart Failure Patients with and without Chronic Kidney Disease

description: <b><i>Background:</i></b> The ability of most biomarkers, such as N-terminal pro-B-type natriuretic peptide (NT-proBNP), to predict prognosis in heart failure can be affected by the state of renal function; therefore, there is the need for a biomarker that can predict prognosis accurately without the influence of renal function. The prognostic value of cysteine-rich protein 61 (CYR61/CCN1) in acute heart failure (AHF) patients has been proven. <b><i>Methods:</i></b> A total of 248 patients hospitalized with AHF were recruited in this study, and serum CCN1 levels, NT-proBNP levels, and other necessary data of patients were collected upon admission. The correlation of serum CCN1 with estimated glomerular filtration rate (eGFR) was investigated, and the logistic regression model was used to investigate the prognostic value of serum CCN1 for 3-month mortality. <b><i>Results:</i></b> Fifty-four of 248 patients died (21.8%) during a 3-month follow-up. Serum CCN1 had no significant correlation with eGFR (rho = –0.088, <i>p</i> = 0.167). In the overall population and patients without chronic kidney disease, results showed that both serum CCN1 and NT-proBNP were significantly associated with 3-month mortality. In patients with chronic kidney disease, serum CCN1 was significantly associated with 3-month mortality in logistic regression analysis (odds ratio = 2.40, <i>p</i> = 0.002) while NT-proBNP was not. Further in tertile group comparison, in patients with chronic kidney disease, higher tertile levels of serum CCN1 had a significantly higher risk of 3-month mortality compared to the lower tertile ones (odds ratio = 4.17, <i>p</i> = 0.013), but that of NT-proBNP did not. <b><i>Conclusion:</i></b> Serum CCN1 level is not associated with eGFR, and it maintains the prognostic value in AHF patients with chronic kidney disease. CCN1 could be a potential novel prognostic biomarker in AHF patients with chronic kidney disease.
DOI: 10.6084/m9.figshare.9751898.v2
title: FLG genotyping results

description: FLG genotyping using KASP technology - results from LGC genomics
DOI: 10.6084/m9.figshare.9751865
title: Crossref Works Dump - August 2019

description: An effort by eLife Sciences to make citation data more accessible.http://elifesciences.org/<br>This dump provides the raw Crossref works JSON responses as a bulk dump, downloaded in August 2019.<br>It was created by retrieving the works from Crossref API http://api.crossref.org/works (using a 1000 rows per page and a cursor).<br>The source code that produced the file can be found here:https://github.com/elifesciences/datacapsule-crossref<br>The output is a 49 GB zip file (using LZMA encryption) contains all of the Crossref raw response. In this case some manuscripts received updates during the download process and therefore will appear twice.<br>To uncompress the file you will need a tool that can handle LZMA (Python 3's zipfile can for example, so can 7zip).<br>The aforementioned project (datacapsule-crossref) also includes code that extracts information from JSON responses included in the zip.
DOI: 10.6084/m9.figshare.9751892.v2
title: Metadata record for: Longitudinal RNA-Seq analysis of acute and chronic neurogenic skeletal muscle atrophy

description: This dataset contains key characteristics about the data described in the Data Descriptor Longitudinal RNA-Seq analysis of acute and chronic neurogenic skeletal muscle atrophy. <br> Contents: <br> 1. human readable metadata summary table in CSV format 2. machine readable metadata file in JSON format<br><br>Versioning Note:Version 2 was generated when the metadata format was updated from JSON to JSON-LD. This was an automatic process that changed only the format, not the contents, of the metadata.<br>
DOI: 10.6084/m9.figshare.9751898.v1
title: FLG genotyping resutls

description: FLG genotyping using KASP technology - results from LGC genomics
DOI: 10.6084/m9.figshare.9751841
title: Supplementary Material for: Aneurysm Architecture: First in vivo Imaging of Human Cerebral Aneurysms with Extravascular Optical Coherence Tomography

description: <b><i>Objective:</i></b> The present study was conducted to explore the value of 3-dimensional microscope integrated extravascular optical coherence tomography (OCT) as the first suitable intraoperative imaging modality of cerebral aneurysm (CA) and parent vessel wall morphology. <b><i>Methods:</i></b> Incidental CAs (<i>n</i> = 16) of the anterior circulation with indication for microsurgical clipping were scanned. <b><i>Results:</i></b> Analysis revealed that intraoperative OCT achieved to delineate the microstructural composition of the parent vessel in all cases and the CA wall in 68.8%. Clinical relevant characteristics such as thickness, calcification, residual tunica media, and atherosclerotic plaque of CA wall could be demonstrated with high image quality approaching the spatial resolution of histopathology. <b><i>Conclusion:</i></b> Our findings demonstrate that intraoperative OCT may hold promise as an additional imaging tool during neurovascular procedures.
DOI: 10.6084/m9.figshare.9751850
title: Database of literature surveyed in "A survey of crowdsourcing in medical image analysis" by Ørting et al.

description: A table with a longer summary of surveyed papers on crowdsourcing in medical imaging, and a shorter summary that is included in the main paper text.
DOI: 10.6084/m9.figshare.9751865.v1
title: Crossref Works Dump - August 2019

description: An effort by eLife Sciences to make citation data more accessible.http://elifesciences.org/<br>This dump provides the raw Crossref works JSON responses as a bulk dump, downloaded in August 2019.<br>It was created by retrieving the works from Crossref API http://api.crossref.org/works (using a 1000 rows per page and a cursor).<br>The source code that produced the file can be found here:https://github.com/elifesciences/datacapsule-crossref<br>The output is a 49 GB zip file (using LZMA encryption) contains all of the Crossref raw response. In this case some manuscripts received updates during the download process and therefore will appear twice.<br>To uncompress the file you will need a tool that can handle LZMA (Python 3's zipfile can for example, so can 7zip).<br>The aforementioned project (datacapsule-crossref) also includes code that extracts information from JSON responses included in the zip.
DOI: 10.6084/m9.figshare.9751892.v1
title: Metadata record for: Longitudinal RNA-Seq analysis of acute and chronic neurogenic skeletal muscle atrophy

description: This dataset contains key characteristics about the data described in the Data Descriptor Longitudinal RNA-Seq analysis of acute and chronic neurogenic skeletal muscle atrophy. <br> Contents: <br> 1. human readable metadata summary table in CSV format 2. machine readable metadata file in JSON format
DOI: 10.6084/m9.figshare.9751823
title: A4: LA–ICP–MS U–Pb analyses of zircons. Cambro–Ordovician anatexis and magmatic recycling at the thinned Gondwana margin: new constraints from the Kouřim Unit, Bohemian Massif

description: Supplementary material A4: LA–ICP–MS U–Pb analyses of zircons.
DOI: 10.6084/m9.figshare.9751823.v1
title: A4: LA–ICP–MS U–Pb analyses of zircons. Cambro–Ordovician anatexis and magmatic recycling at the thinned Gondwana margin: new constraints from the Kouřim Unit, Bohemian Massif

description: Supplementary material A4: LA–ICP–MS U–Pb analyses of zircons.
DOI: 10.6084/m9.figshare.9751850.v2
title: Database of literature surveyed in "A survey of crowdsourcing in medical image analysis" by Ørting et al.

description: A table with a longer summary of surveyed papers on crowdsourcing in medical imaging, and a shorter summary that is included in the main paper text.
DOI: 10.6084/m9.figshare.9751850.v1
title: Database of literature surveyed in "A survey of crowdsourcing in medical image analysis" by Ørting et al.

description: A table with a longer summary of surveyed papers on crowdsourcing in medical imaging, and a shorter summary that is included in the main paper text.
DOI: 10.6084/m9.figshare.9751793
title: Supplementary Material for: An Integrated Kidney Care eConsult Practice Model: Results from the iKinect Project

description: <b><i>Background:</i></b> Collaborative management of kidney disease relies on coordinated and effective partnerships between multiple provider teams. Siloed care contributes to limited access between physicians, resulting in delays in the diagnosis and treatment of kidney disease and inappropriate use of healthcare resources. These gaps contribute to dissatisfied and disempowered providers and patients. Digital systems such as eConsult can support collaborative management and address these gaps, thereby streamlining the consultation and referral process between primary care physicians (PCPs) and nephrologists. In this study, we evaluated an established eConsult platform integrated with a central triage process for a network of PCPs and nephrologists. The study aimed to assess the acceptability, feasibility, and impact on access to nephrology when using eConsult integrated into the management of kidney disease between PCPs and nephrologists. <b><i>Methods:</i></b> We conducted a 1-year pilot study and used mixed methods to measure the acceptability and feasibility of using eConsult for the management of kidney disease. We compared eConsult and traditional referrals with respect to types of consultation, referrals, and times to response to determine impact on access to kidney care. We conducted semi-structured interviews of PCPs and nephrologists to assess physician experience. <b><i>Results:</i></b> From January 8, 2018, to January 11, 2019, 52 PCPs and 23 nephrologists participated in the study, with 250 traditional referrals and 106 eConsults submitted during that period. The median response time for eConsult was 15 (3–64) h, with 25% originating outside the central Toronto region. The median time to first clinic appointment from a traditional referral was 4 months (111 [61–163] days). PCP and nephrologist interviews revealed high user satisfaction, citing efficiency and timely response as key facilitators. <b><i>Conclusion:</i></b> The eConsult platform was acceptable, feasible, and facilitated access to nephrology care compared to traditional referrals. Physicians report improvements in physician care delivery, nephrology care gaps, patient experience, and healthcare utilization.
DOI: 10.6084/m9.figshare.9751796
title: Supplementary Material for: Spicy Food Consumption and Risk of Uninvestigated Heartburn in Isfahani Adults

description: <b><i>Background/Objective:</i></b> Dietary recommendations for the consumption of spicy foods in uninvestigated heartburn are still under debate. We examine the association between spicy food consumption and the prevalence of uninvestigated heartburn in a large sample of Iranian adults. <b><i>Methods:</i></b> This cross-sectional study was conducted among 4,633 Iranian adults living in Isfahan (2,046 men, 2,587 women) in 2010. The average daily intake of spicy foods was estimated using a dietary habit questionnaire. Uninvestigated heartburn was defined, using a validated Rome III questionnaire, as the presence of heartburn sometimes, often or always during the last 3 months. <b><i>Results:</i></b> Uninvestigated heartburn was prevalent in 23.8% (<i>n</i> = 1,103) of participants. After controlling for potential confounders, including dietary behaviors and body mass index, men consuming spicy foods ≥10 times/week were 2.63 times more likely to have uninvestigated heartburn (95% CI:1.28–5.36) compared with those who never consumed spicy foods. Also, those men with the highest consumption of spicy foods were 3 times more likely to experience heartburn frequently (95% CI 1.44–6.39) compared with men with the lowest intake. No overall significant associations were found between the consumption of spicy foods and uninvestigated heartburn, including the frequency and severity of heartburn, in women. When the analysis was restricted to those with uninvestigated heartburn, no significant associations were found between consumption of spicy foods and frequency of heartburn either in men or women. <b><i>Conclusion:</i></b> The present findings suggest that high consumption of spicy foods was associated with a greater risk of uninvestigated heartburn in men, but not in women. Further studies, particularly of a prospective nature, are needed to confirm our findings, as well as underlying mechanisms.
DOI: 10.6084/m9.figshare.9751793.v1
title: Supplementary Material for: An Integrated Kidney Care eConsult Practice Model: Results from the iKinect Project

description: <b><i>Background:</i></b> Collaborative management of kidney disease relies on coordinated and effective partnerships between multiple provider teams. Siloed care contributes to limited access between physicians, resulting in delays in the diagnosis and treatment of kidney disease and inappropriate use of healthcare resources. These gaps contribute to dissatisfied and disempowered providers and patients. Digital systems such as eConsult can support collaborative management and address these gaps, thereby streamlining the consultation and referral process between primary care physicians (PCPs) and nephrologists. In this study, we evaluated an established eConsult platform integrated with a central triage process for a network of PCPs and nephrologists. The study aimed to assess the acceptability, feasibility, and impact on access to nephrology when using eConsult integrated into the management of kidney disease between PCPs and nephrologists. <b><i>Methods:</i></b> We conducted a 1-year pilot study and used mixed methods to measure the acceptability and feasibility of using eConsult for the management of kidney disease. We compared eConsult and traditional referrals with respect to types of consultation, referrals, and times to response to determine impact on access to kidney care. We conducted semi-structured interviews of PCPs and nephrologists to assess physician experience. <b><i>Results:</i></b> From January 8, 2018, to January 11, 2019, 52 PCPs and 23 nephrologists participated in the study, with 250 traditional referrals and 106 eConsults submitted during that period. The median response time for eConsult was 15 (3–64) h, with 25% originating outside the central Toronto region. The median time to first clinic appointment from a traditional referral was 4 months (111 [61–163] days). PCP and nephrologist interviews revealed high user satisfaction, citing efficiency and timely response as key facilitators. <b><i>Conclusion:</i></b> The eConsult platform was acceptable, feasible, and facilitated access to nephrology care compared to traditional referrals. Physicians report improvements in physician care delivery, nephrology care gaps, patient experience, and healthcare utilization.
DOI: 10.6084/m9.figshare.9751778
title: Microsatellite data of the studied baobab trees in Kenya from Genetic diversity and structure of baobab (<i>Adansonia digitata</i> L.) in southeastern Kenya

description: List of microsatellite data for each individual tree
DOI: 10.6084/m9.figshare.9751778.v1
title: Microsatellite data of the studied baobab trees in Kenya from Genetic diversity and structure of baobab (<i>Adansonia digitata</i> L.) in southeastern Kenya

description: List of microsatellite data for each individual tree
DOI: 10.6084/m9.figshare.9751766
title: Supplemental Data Banerjee, Grover, Ganesh and Sridharan, J. Neurophys. (2019)

description: Supplemental data and raw data sources for Banerjee, Grover, Ganesh and Sridharan, J. Neurophys. (2019)
DOI: 10.6084/m9.figshare.9751766.v1
title: Supplemental Data Banerjee, Grover, Ganesh and Sridharan, J. Neurophys. (2019)

description: Supplemental data and raw data sources for Banerjee, Grover, Ganesh and Sridharan, J. Neurophys. (2019)
DOI: 10.6084/m9.figshare.9751745
title: ifenprodil wildtype and mutant TEVC.opjuA common mechanism allows selective targeting of GluN2B subunit-containing N-methyl-D-aspartate receptors

description: Original data used for the generation of figures in Schreiber et al..<br>
DOI: 10.6084/m9.figshare.9751748
title: compound 2 wildtype and mutant TEVC.opjuA common mechanism allows selective targeting of GluN2B subunit-containing N-methyl-D-aspartate receptors

description: Original data used for the generation of figures in Schreiber et al..<br>
DOI: 10.6084/m9.figshare.9751751
title: Raw data.zipA common mechanism allows selective targeting of GluN2B subunit-containing N-methyl-D-aspartate receptors

description: Original data used for the generation of figures in Schreiber et al..<br>
DOI: 10.6084/m9.figshare.9751742
title: compound 3,4,5,6,7 and rac-1 wildtype TEVC.opjuA common mechanism allows selective targeting of GluN2B subunit-containing N-methyl-D-aspartate receptors

description: Original data used for the generation of figures in Schreiber et al..<br>
DOI: 10.6084/m9.figshare.9751751.v1
title: Raw data.zipA common mechanism allows selective targeting of GluN2B subunit-containing N-methyl-D-aspartate receptors

description: Original data used for the generation of figures in Schreiber et al..<br>
DOI: 10.6084/m9.figshare.9751745.v1
title: ifenprodil wildtype and mutant TEVC.opjuA common mechanism allows selective targeting of GluN2B subunit-containing N-methyl-D-aspartate receptors

description: Original data used for the generation of figures in Schreiber et al..<br>
DOI: 10.6084/m9.figshare.9751736
title: compound (R)-1 wildtype and mutant TEVC.opjuA common mechanism allows selective targeting of GluN2B subunit-containing N-methyl-D-aspartate receptors

description: Original data used for the generation of figures in Schreiber et al..<br>
DOI: 10.6084/m9.figshare.9751739
title: compound (S)-1 wildtype and mutant TEVC.opjuA common mechanism allows selective targeting of GluN2B subunit-containing N-methyl-D-aspartate receptors

description: Original data used for the generation of figures in Schreiber et al..<br>
DOI: 10.6084/m9.figshare.9751742.v1
title: compound 3,4,5,6,7 and rac-1 wildtype TEVC.opjuA common mechanism allows selective targeting of GluN2B subunit-containing N-methyl-D-aspartate receptors

description: Original data used for the generation of figures in Schreiber et al..<br>
DOI: 10.6084/m9.figshare.9751730
title: Supplementary Material for: Comparison of Different Selection Strategies for Tolvaptan Eligibility among Autosomal Dominant Polycystic Kidney Disease Patients

description: <b><i>Background:</i></b> Tolvaptan can slow down renal function decline in autosomal dominant polycystic kidney disease (­ADPKD). While there is consensus across international recommendations that the drug should only be used in patients with high risk of rapid progression, identification criteria for rapid progression vary. Here, we investigated different assessment strategies using a real-life ADPKD cohort. <b><i>Methods:</i></b> Observational retrospective cohort analysis. The study included 131 ADPKD patients aged 19–78 years who were referred to the Hannover Medical School outpatient clinic for evaluation of tolvaptan treatment. Six different assessment strategies for tolvaptan eligibility were tested for each patient. Comparative analysis for different assessments was performed in the total study population, the subpopulation with available computed tomography/magnetic resonance imaging data, and the genotyped subpopulation. <b><i>Results:</i></b> Comparing 6 assessment strategies revealed strong variations in the individual selection processes resulting in treatment recommendations for 14.5–64.9% of patients. The highest patient number was selected by the Scottish and the lowest by the Japanese approach. Few patients had positive recommendations by all 6 systems, but strong congruency was observed between the Scottish, U.K. and Canadian patient selection. The lowest number of overlapping patients was found between the Japanese and the ERA-EDTA selection. Important discrepancies were also found between the ERA-EDTA and the U.S. system due to different emphases on parameters of kidney function versus kidney volume. Limitations of the study included the restricted sample size, heterogeneity in parameter availability and lack of outcome data. <b><i>Conclusions:</i></b> The study draws attention to important discrepancies between different decision algorithms for tolvaptan eligibility in ADPKD patients.
DOI: 10.6084/m9.figshare.9751736.v1
title: compound (R)-1 wildtype and mutant TEVC.opjuA common mechanism allows selective targeting of GluN2B subunit-containing N-methyl-D-aspartate receptors

description: Original data used for the generation of figures in Schreiber et al..<br>
DOI: 10.6084/m9.figshare.9751739.v1
title: compound (S)-1 wildtype and mutant TEVC.opjuA common mechanism allows selective targeting of GluN2B subunit-containing N-methyl-D-aspartate receptors

description: Original data used for the generation of figures in Schreiber et al..<br>