cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.25274138
title: Geographical distribution of clinical trials in amyotrophic lateral sclerosis: a scoping review

description: <i>Introduction</i>: Clinical trials location is determined by many factors, including the availability of patient populations, regulatory environment, scientific expertise, and cost considerations. In clinical drug development of amyotrophic lateral sclerosis (ALS), where genetic differences have been described and may be related to geographic setting, this could have implications for the clinical interpretation of results in underrepresented geographic settings. <i>Objective</i>: The aim of this study was to review country participation in ALS clinical research based on available data from clinical trial registries and databases. <i>Methods</i>: We performed a scoping review with available information about clinical trials on ALS in ClinicalTrials.gov (CT), EU clinical trials register (EudraCT), WHO International Clinical Trials Registry Platform (ICTRP) and Web of Science (WOS). Inclusion criteria were clinical trials in phase 2 and 3 to treat ALS, recruiting or active not recruiting, from 23/06/2018 to 23/06/2023. <i>Results</i>: The total number of clinical trials identified were 188; 54 studies in CT, 38 in EudraCT, 47 in ICTRP and 49 in WOS. We identified 77 clinical trials after deleting duplicates and applying exclusion criteria. The countries with most studies conducted were the US with 35 studies (10.9%), followed by the United Kingdom, Belgium, France and Germany with 21 studies each one of them (6.5%). <i>Conclusion</i>: The data obtained in our review showed a non-homogeneous distribution in clinical trials at the international level, which may influence the interpretation of the results obtained.
DOI: 10.6084/m9.figshare.25274138.v1
title: Geographical distribution of clinical trials in amyotrophic lateral sclerosis: a scoping review

description: <i>Introduction</i>: Clinical trials location is determined by many factors, including the availability of patient populations, regulatory environment, scientific expertise, and cost considerations. In clinical drug development of amyotrophic lateral sclerosis (ALS), where genetic differences have been described and may be related to geographic setting, this could have implications for the clinical interpretation of results in underrepresented geographic settings. <i>Objective</i>: The aim of this study was to review country participation in ALS clinical research based on available data from clinical trial registries and databases. <i>Methods</i>: We performed a scoping review with available information about clinical trials on ALS in ClinicalTrials.gov (CT), EU clinical trials register (EudraCT), WHO International Clinical Trials Registry Platform (ICTRP) and Web of Science (WOS). Inclusion criteria were clinical trials in phase 2 and 3 to treat ALS, recruiting or active not recruiting, from 23/06/2018 to 23/06/2023. <i>Results</i>: The total number of clinical trials identified were 188; 54 studies in CT, 38 in EudraCT, 47 in ICTRP and 49 in WOS. We identified 77 clinical trials after deleting duplicates and applying exclusion criteria. The countries with most studies conducted were the US with 35 studies (10.9%), followed by the United Kingdom, Belgium, France and Germany with 21 studies each one of them (6.5%). <i>Conclusion</i>: The data obtained in our review showed a non-homogeneous distribution in clinical trials at the international level, which may influence the interpretation of the results obtained.
DOI: 10.6084/m9.figshare.25134897
title: Verbal expressive language minimally affected in non-demented people living with amyotrophic lateral sclerosis

description: <i>Objective:</i> Language dysfunction is one of the most common cognitive impairments in amyotrophic lateral sclerosis (ALS). Although discourse capacities are essential for daily functioning, verbal expressive language has not been widely investigated in ALS. The existing research available suggests that discourse impairments are prevalent. This study investigates verbal expressive language in people living with ALS (plwALS) in contrast to healthy controls (HC). <i>Methods:</i> 64 plwALS and 49 age, gender and education-matched healthy controls were ask to describe the Cookie Theft Picture Task. The recordings were analyzed for discourse productivity, discourse content, syntactic complexity, speech fluency and verb processing. We applied the Bayesian hypothesis-testing framework, incorporating the effects of dysarthria, cognitive impairment status (CIS), and premorbid crystalline verbal IQ. <i>Results:</i> Compared to HC, plwALS only showed a single impairment: speech dysfluency. Discourse productivity, discourse content, syntactic complexity and verb processing were not impaired. Cognition and dysarthria exceeded the influence of verbal IQ for total words spoken and content density. Cognition alone seemed to explain dysfluency. Body-agent verbs were produced at even higher rates than other verb types. For the remaining outcomes, verbal IQ was the most decisive factor. <i>Conclusions:</i> In contrast to existing research, our data demonstrates no discernible impairment in verbal expressive language in ALS. What our findings show to be decisive is accounting for the influence of dysarthria, cognitive impairment status, and verbal IQ as variables on spontaneous verbal expressive language. Minor impairments in verbal expressive language appear to be influenced to a greater degree by executive dysfunctioning and dysarthria than by language impairment.
DOI: 10.6084/m9.figshare.25134897.v1
title: Verbal expressive language minimally affected in non-demented people living with amyotrophic lateral sclerosis

description: <i>Objective:</i> Language dysfunction is one of the most common cognitive impairments in amyotrophic lateral sclerosis (ALS). Although discourse capacities are essential for daily functioning, verbal expressive language has not been widely investigated in ALS. The existing research available suggests that discourse impairments are prevalent. This study investigates verbal expressive language in people living with ALS (plwALS) in contrast to healthy controls (HC). <i>Methods:</i> 64 plwALS and 49 age, gender and education-matched healthy controls were ask to describe the Cookie Theft Picture Task. The recordings were analyzed for discourse productivity, discourse content, syntactic complexity, speech fluency and verb processing. We applied the Bayesian hypothesis-testing framework, incorporating the effects of dysarthria, cognitive impairment status (CIS), and premorbid crystalline verbal IQ. <i>Results:</i> Compared to HC, plwALS only showed a single impairment: speech dysfluency. Discourse productivity, discourse content, syntactic complexity and verb processing were not impaired. Cognition and dysarthria exceeded the influence of verbal IQ for total words spoken and content density. Cognition alone seemed to explain dysfluency. Body-agent verbs were produced at even higher rates than other verb types. For the remaining outcomes, verbal IQ was the most decisive factor. <i>Conclusions:</i> In contrast to existing research, our data demonstrates no discernible impairment in verbal expressive language in ALS. What our findings show to be decisive is accounting for the influence of dysarthria, cognitive impairment status, and verbal IQ as variables on spontaneous verbal expressive language. Minor impairments in verbal expressive language appear to be influenced to a greater degree by executive dysfunctioning and dysarthria than by language impairment.
DOI: 10.6084/m9.figshare.25249639
title: Using morpho-anatomical characters of leaves and stems for distinguishing <i>Bolboschoenus</i> taxa: a case study of Serbian species

description: The genus <i>Bolboschoenus</i> has been intensively studied from the morphological, ecological and physiological aspects, however, anatomical features of stems, leaves and epidermal structures of leaves have not been investigated sufficiently yet. The main objective of this study was to compare the four <i>Bolboschoenus</i> species growing in Serbia at the anatomical level and to define the most important anatomical characteristics for distinguishing these species. Descriptive, nonmetric multidimensional scaling and canonical discriminant analysis of the anatomical characters of leaves, stems and epidermal structures have been conducted for these purposes. The number and position of sclerenchyma strands in the leaves, the presence of bulliform cells in the epidermis, the number of translucent cell layers under the adaxial epidermis in the midrib area of the lamina, the number of aerial cavities in leaves and stems were the most significant anatomical characters for differentiation of species. The most differentiated species was <i>B. glaucus</i>, while <i>B. laticarpus</i> occupied an intermediate position between <i>B. maritimus</i> and <i>B. planiculmis</i>, on the one hand, and <i>B. glaucus</i> on the other. The combination of the anatomical features of leaves and stems and the epidermal structures had a more excellent taxonomic value than these three individual groups of features individually.
DOI: 10.6084/m9.figshare.25249639.v1
title: Using morpho-anatomical characters of leaves and stems for distinguishing <i>Bolboschoenus</i> taxa: a case study of Serbian species

description: The genus <i>Bolboschoenus</i> has been intensively studied from the morphological, ecological and physiological aspects, however, anatomical features of stems, leaves and epidermal structures of leaves have not been investigated sufficiently yet. The main objective of this study was to compare the four <i>Bolboschoenus</i> species growing in Serbia at the anatomical level and to define the most important anatomical characteristics for distinguishing these species. Descriptive, nonmetric multidimensional scaling and canonical discriminant analysis of the anatomical characters of leaves, stems and epidermal structures have been conducted for these purposes. The number and position of sclerenchyma strands in the leaves, the presence of bulliform cells in the epidermis, the number of translucent cell layers under the adaxial epidermis in the midrib area of the lamina, the number of aerial cavities in leaves and stems were the most significant anatomical characters for differentiation of species. The most differentiated species was <i>B. glaucus</i>, while <i>B. laticarpus</i> occupied an intermediate position between <i>B. maritimus</i> and <i>B. planiculmis</i>, on the one hand, and <i>B. glaucus</i> on the other. The combination of the anatomical features of leaves and stems and the epidermal structures had a more excellent taxonomic value than these three individual groups of features individually.
DOI: 10.6084/m9.figshare.25598462
title: Ethnobotanical studies on the Tyrrhenian side of the Aspromonte Massif (Calabria, Southern Italy)

description: A great deal of ethnobotanical knowledge, passed down from generation to generation by oral tradition, is still preserved in the Mediterranean basin. Over the years, efforts have been made to collect this information to avoid losing this heritage. This work is a contribution towards the ethnobotanical knowledge of Calabria (southern Italy) through a survey on the Tyrrhenian side of the Aspromonte Massif in the metropolitan city of Reggio Calabria, an area that has been little studied from the ethnobotanical point of view. For this purpose, several semi-structured interviews were conducted with informants on the current and past use of spontaneous and cultivated plants in this study area; the data were collected in a Microsoft Excel<sup>®</sup> spreadsheet and then processed. Fifty-nine people were interviewed. Results show that the most frequently used plant family is Asteraceae, the most mentioned taxon is <i>Anethum piperitum</i> (22 interviews), and the most recurrent use is use is culinary, for the preparation of side-dishes. This work highlights the presence of cultures that have used plants in the past and represents a further contribution to the ethnobotanical knowledge of this region.
DOI: 10.6084/m9.figshare.25598462.v1
title: Ethnobotanical studies on the Tyrrhenian side of the Aspromonte Massif (Calabria, Southern Italy)

description: A great deal of ethnobotanical knowledge, passed down from generation to generation by oral tradition, is still preserved in the Mediterranean basin. Over the years, efforts have been made to collect this information to avoid losing this heritage. This work is a contribution towards the ethnobotanical knowledge of Calabria (southern Italy) through a survey on the Tyrrhenian side of the Aspromonte Massif in the metropolitan city of Reggio Calabria, an area that has been little studied from the ethnobotanical point of view. For this purpose, several semi-structured interviews were conducted with informants on the current and past use of spontaneous and cultivated plants in this study area; the data were collected in a Microsoft Excel<sup>®</sup> spreadsheet and then processed. Fifty-nine people were interviewed. Results show that the most frequently used plant family is Asteraceae, the most mentioned taxon is <i>Anethum piperitum</i> (22 interviews), and the most recurrent use is use is culinary, for the preparation of side-dishes. This work highlights the presence of cultures that have used plants in the past and represents a further contribution to the ethnobotanical knowledge of this region.
DOI: 10.6084/m9.figshare.25555751
title: Technological acceptance and features needed in mobile health apps development for people living with dementia and their caregivers in Indonesia

description: In Indonesia, the number of People Living with Dementia (PLWD) is predicted to be rising continuously. PLWD need help operating cell phones for their daily needs. Numerous mobile health applications have been innovated to deliver better dementia care. The objective of this study is to identify the technological acceptance and features needed by PLWD and caregivers in Indonesia. This study started with questionnaire development through focused-group discussion with experts, caregivers and PLWD. It was followed by item development involving experts in geriatrics (psychiatry, internal medicine, medical rehabilitation and neurology) to prepare an online questionnaire. We considered using jargon and words that are familiar to users. The data collected was analyzed for the technological acceptance model (TAM) using Structural Equation Model (SEM). This study showed that perceived usefulness and ease of use of the technology have positively correlated to the actual use. This study reflects the need for social connectedness and information for PLWD. For caregivers, the main feature needed is information related to dementia symptoms and treatment. The understanding gained from this study can be used to improve strategies related to developing mobile health technology for PLWD and caregivers.
DOI: 10.6084/m9.figshare.25555751.v1
title: Technological acceptance and features needed in mobile health apps development for people living with dementia and their caregivers in Indonesia

description: In Indonesia, the number of People Living with Dementia (PLWD) is predicted to be rising continuously. PLWD need help operating cell phones for their daily needs. Numerous mobile health applications have been innovated to deliver better dementia care. The objective of this study is to identify the technological acceptance and features needed by PLWD and caregivers in Indonesia. This study started with questionnaire development through focused-group discussion with experts, caregivers and PLWD. It was followed by item development involving experts in geriatrics (psychiatry, internal medicine, medical rehabilitation and neurology) to prepare an online questionnaire. We considered using jargon and words that are familiar to users. The data collected was analyzed for the technological acceptance model (TAM) using Structural Equation Model (SEM). This study showed that perceived usefulness and ease of use of the technology have positively correlated to the actual use. This study reflects the need for social connectedness and information for PLWD. For caregivers, the main feature needed is information related to dementia symptoms and treatment. The understanding gained from this study can be used to improve strategies related to developing mobile health technology for PLWD and caregivers.
DOI: 10.15468/dl.ck6jn8
title: Occurrence Download

description: A dataset containing 1546 species occurrences available in GBIF matching the query:
{
 "and" : [
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 "TaxonKey is Sannantha pluriflora (F.Muell.) Peter G.Wilson"
 ]
}

 The dataset includes 1546 records from 25 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0024816-240626123714530/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.7278/s5d-wtpn-az0j
title: Alta Atwater PARSIVEL Disdrometer Measurements 2022–2024
DOI: 10.15468/dl.tbue4f
title: Occurrence Download

description: A dataset containing 2 species occurrences available in GBIF matching the query:
{
 "and" : [
 "HasGeospatialIssue is false",
 "HasCoordinate is true",
 "OccurrenceStatus is Present",
 {
 "not" : {
 "BasisOfRecord" : [
 "is one of (Fossil, Material sample)"
 ]
 }
 },
 "TaxonKey is Otomys cheesmani Taylor, Lavrenchenko, Carleton, Verheyen, Bennett, Oosthuizen & Maree, 2011",
 "Continent is one of (Africa)",
 "Year is greater than or equal to 1900"
 ]
}

 The dataset includes 2 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0034009-250525065834625/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.479ze6
title: Occurrence Download

description: A dataset containing 362 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Lindera thomsonii C.K.Allen"
 ]
}

 The dataset includes 362 records from 24 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0196244-200613084148143/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.2zpbyc
title: Occurrence Download

description: A dataset containing 67 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Corydalis triternata Zucc."
 ]
}

 The dataset includes 67 records from 12 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0013003-240314170635999/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.dgbhsc
title: Occurrence Download

description: A dataset containing 112 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is Colombia",
 "TaxonKey is Noctilio leporinus (Linnaeus, 1758)"
 ]
}

 The dataset includes 112 records from 27 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0049344-181108115102211/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.b85vub
title: Occurrence Download

description: A dataset containing 354 species occurrences available in GBIF matching the query:
{
 "and" : [
 "BasisOfRecord is Human Observation",
 {
 "or" : [
 "Country is Nigeria",
 "Country is Liberia",
 "Country is Sierra Leone",
 "Country is Ghana"
 ]
 },
 {
 "or" : [
 "PublishingOrg is e2e717bf-551a-4917-bdc9-4fa0f342c530",
 "PublishingOrg is 335880a0-e2e1-11dd-8102-b8a03c50a862",
 "PublishingOrg is ffa16949-1a2d-45c7-a3af-726e6d227d18",
 "PublishingOrg is 57c9be37-aeac-410c-8cea-2aea1a472f07"
 ]
 },
 "TaxonKey is Bycanistes fistulator (Cassin, 1850)",
 "Year 2000-2015"
 ]
}

 The dataset includes 354 records from 5 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0226819-200613084148143/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.i2dkmg
title: Occurrence Download

description: A dataset containing 8779 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is United States of America",
 "TaxonKey is Agraulis vanillae (Linnaeus, 1758)"
 ]
}

 The dataset includes 8779 records from 32 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0049347-181108115102211/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.yj48kk
title: Occurrence Download

description: A dataset containing 51 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Corydalis triternatifolia C.Y.Wu"
 ]
}

 The dataset includes 51 records from 9 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0013004-240314170635999/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.mgnnn3
title: Occurrence Download

description: A dataset containing 836 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Sceloporus omiltemanus Günther, 1890"
 ]
}

 The dataset includes 836 records from 24 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0166783-220831081235567/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.dbmtur
title: Occurrence Download

description: A dataset containing 645 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Cistothorus apolinari Chapman, 1914"
 ]
}

 The dataset includes 645 records from 21 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0049350-181108115102211/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.pusfne
title: Occurrence Download

description: A dataset containing 128 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Firmiana fulgens (Wall. ex Mast.) Schum."
 ]
}

 The dataset includes 128 records from 18 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0003675-240321170329656/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.2q65zk
title: Occurrence Download

description: A dataset containing 3 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Centropogon bruneotomentosus E.Wimm."
 ]
}

 The dataset includes 3 records from 3 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0150592-240321170329656/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.08kb8h
title: Occurrence Download

description: A dataset containing 2375 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Argemone mexicana L.",
 "HasCoordinate is TRUE"
 ]
}

 The dataset includes 2375 records from 191 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0049353-180508205500799/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.