DOI: 10.6084/m9.figshare.11417295
title: Anatomy of the left ventricle in fibrotic non-ischaemic dilated cardiomyopathy (NIDCM)

description: Supporting data for the study titled "<b>Left Ventricular Shape Predicts Arrhythmic Risk in Fibrotic Dilated Cardiomyopathy</b>" published in Europace (https://doi.org/10.1093/europace/euab306) <br>Collection of 156 computational meshes of the anatomy of the left ventricle of 156 subjects with fibrotic NIDCM. <b><br></b><b>Data acquisition and segmentation</b> Original Late Gadolinium Enganced (LGE-CMR) images originate from a cohort of 156 patients enrolled in the Royal Brompton Hospital Cardiovascular Biobank Project. Short axis LGE-CMR images stacks were acquired with an acquired scanning resolution of 1.3-2.2mm in plane and with a 7-10.5mm slice thickness. LGE-CMR stacks were manually segmented. An additional point was marked, the most basal point of the RV epicardium that meets the liver, required to break the circumferential symmetry of the LV in the ventricular shape models, and providing a marker for the most basal slice (images above this slice were removed). <b><br></b><b>3D meshing</b>The LV end diastolic anatomy was reconstructed from the short axis image contours using high order interpolation meshes. An idealised ellipsoid (with 96 elements, 194 nodes and 4656 degrees of freedom) was tailored to the dimensions of each case, and image registration and mesh warping techniques used to fit an idealised ellipsoid to each patient’s contours. High-order interpolation basis functions (cubic Hermite) in the meshes were used to interpolate the typically sparse out of plane resolutions in the short axis acquisitions. The 156 meshes were then spatially aligned by their centres of mass, and oriented by their basal planes and manually marked points at the RV epicardium. <br>Data shared contains:<b>1. AtlasMeshData.zip</b>, where each case has 1.1 IDseg.nii: The mask (segmentation) of the left ventricular (LV) myocardium and right ventricular blood pool from the short axis magnetic resonance image in end diastole. NIFTI format.1.2 IDseg_mesh files: the degrees of freedom of the cubic Hermite mesh that was personalised to the anatomy of the left ventricle1.3 Image_IDseg_mesh.jpg: image of the overlay between the fitted mesh and the mask of the LV myocardium1.4 Image_Initialization.jpg: image of the overlay between the template LV mesh used for personalization and the mask of the LV myocardium1.5 ImageDistances2ClosestPointIDseg_meshxxxxxxxxxx.jpg: image of the distances between the LV mesh and the mask of the LV myocardium (xxxxxxxxxx is a digit encodign for the time when the image was generated)1.6 PersonalizationReportbinary.txt: file with metrics of mesh fitting accuracy and quality1.7 GeoReport.txt: file with the collection of most prevalent geometrical descriptors of the left ventricle, 1.8 CurvatureMetrics.mat, GeometricalMetrics.mat and ThicknessMetrics.mat: matlab files with a comprehensive collection of descriptors of the left ventricle.<b></b><i></i><sub></sub><sup></sup><b></b><br><b>2. VTKMeshes.zip</b>: the collection of all the LV shapes in VTK format, after correction of centre of mass and circumferential orientation. <br><b>3. patient_outcomes2.xlsx</b>: the excel file with the classification of mortality and arrhythmia endpoints. <b></b><i></i><sub></sub><sup></sup><br> <b></b><i></i><sub></sub><sup></sup><b></b><i></i><sub></sub><sup></sup><br>