cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.12887462.v2
title: Cost burden of breakthrough hemolysis in patients with paroxysmal nocturnal hemoglobinuria receiving ravulizumab versus eculizumab

description: <b>Objectives:</b> Although complement inhibition is highly effective, patients with paroxysmal nocturnal hemoglobinuria (PNH) may experience intravascular breakthrough hemolysis (BTH). Underlying causes may include elevated free C5, pregnancy, or non-pregnancy complement-activating conditions (e.g. infections). This study compared BTH-related resource utilization and costs in PNH patients treated with eculizumab versus ravulizumab. <b>Methods:</b> A cost model was developed using data from a targeted literature review and a survey of experienced clinicians. Costs associated with BTH episodes were calculated by cause and weighted by the proportion attributed to each cause and the cost of treating each episode. The model captured direct medical costs in 2018 US dollars. Annual BTH-related healthcare resource utilization was also calculated. <b>Results:</b> BTH episodes in the literature were commonly associated with elevated lactate dehydrogenase and aspartate aminotransferase, hemoglobinuria, transfusion needs, and/or recurrence of PNH symptoms. The majority of BTH management costs in eculizumab-treated patients related to changing from the approved dosing regimen following an episode of BTH, rather than acute management. No ongoing dosing changes were expected for ravulizumab-treated patients following episodes of BTH, substantially reducing its ongoing management costs. Resource utilization was greater for eculizumab-treated patients than ravulizumab-treated patients due to higher incidence of BTH, and risk of elevated free C5-related BTH. Total incremental cost was substantially lower for ravulizumab- vs eculizumab-treated patients ($407 vs $9379); results were consistent when pregnant women were not included ($386 vs $3472). <b>Conclusion:</b> Overall resource use and costs for BTH are estimated to be lower for PNH patients receiving ravulizumab compared with eculizumab.
DOI: 10.6084/m9.figshare.12848172
title: Comprehensive screening for coexisting heterozygous α<sup>0</sup>-thalassemia in hemoglobin E trait

description: <b>Objectives:</b> A sensitive screening for the coexistence of α<sup>0</sup>-thalassemia and the hemoglobin E (Hb E) trait is important to identify at-risk couples for hydrops fetalis. However, previous cutoff values have shown a positive predictive value (PPV) of only 50% or less. This study aimed to define more specific indicators to reduce the need for DNA tests. <b>Methods:</b> Patients with Hb E trait, as diagnosed by high performance liquid chromatography (HPLC) and/or isoelectric focusing (IEF) techniques, were tested for α<sup>0</sup>-thalassemia and α<sup>+</sup>-thalassemia deletions using multiplex gap polymerase chain reaction. Iron deficiency anemia (IDA) were excluded using a red cell distribution width (RDW) of more than 14.5%. <b>Results:</b> From 390 specimens, suitable cutoff values showing a 100% sensitivity for detection of heterozygous α<sup>0</sup>-thalassemia were an Hb E level of less than 22% by HPLC, a mean corpuscular volume (MCV) of less than 72 fL, and a mean corpuscular hemoglobin (MCH) level of less than 22.5 pg. Comparable results were obtained in the validation cohort (<i>N</i> = 179). Using a combination of Hb E with either MCV or MCH cutoff points gave a PPV of 76.2% and 77.4%, respectively. <b>Discussion:</b> IDA was reported to interfere with Hb E level. In this study, we excluded IDA using RDW of more than 14.5% to enhance the test specificity. <b>Conclusion:</b> Lower cutoff screening values can be used to exclude α<sup>0</sup>-thalassemia in the Hb E trait yielding a higher specificity in a normal RDW condition. This can save the cost and labor of DNA testing.
DOI: 10.6084/m9.figshare.12848172.v1
title: Comprehensive screening for coexisting heterozygous α<sup>0</sup>-thalassemia in hemoglobin E trait

description: <b>Objectives:</b> A sensitive screening for the coexistence of α<sup>0</sup>-thalassemia and the hemoglobin E (Hb E) trait is important to identify at-risk couples for hydrops fetalis. However, previous cutoff values have shown a positive predictive value (PPV) of only 50% or less. This study aimed to define more specific indicators to reduce the need for DNA tests. <b>Methods:</b> Patients with Hb E trait, as diagnosed by high performance liquid chromatography (HPLC) and/or isoelectric focusing (IEF) techniques, were tested for α<sup>0</sup>-thalassemia and α<sup>+</sup>-thalassemia deletions using multiplex gap polymerase chain reaction. Iron deficiency anemia (IDA) were excluded using a red cell distribution width (RDW) of more than 14.5%. <b>Results:</b> From 390 specimens, suitable cutoff values showing a 100% sensitivity for detection of heterozygous α<sup>0</sup>-thalassemia were an Hb E level of less than 22% by HPLC, a mean corpuscular volume (MCV) of less than 72 fL, and a mean corpuscular hemoglobin (MCH) level of less than 22.5 pg. Comparable results were obtained in the validation cohort (<i>N</i> = 179). Using a combination of Hb E with either MCV or MCH cutoff points gave a PPV of 76.2% and 77.4%, respectively. <b>Discussion:</b> IDA was reported to interfere with Hb E level. In this study, we excluded IDA using RDW of more than 14.5% to enhance the test specificity. <b>Conclusion:</b> Lower cutoff screening values can be used to exclude α<sup>0</sup>-thalassemia in the Hb E trait yielding a higher specificity in a normal RDW condition. This can save the cost and labor of DNA testing.
DOI: 10.6084/m9.figshare.12200249.v1
title: Identification of potential miRNA–mRNA interaction network in bone marrow T cells of acquired aplastic anemia

description: <b>Background:</b> MicroRNAs(miRNAs) can regulate T cell differentiation and plasticity by targeting their corresponding message RNAs (mRNAs), which play important roles in many autoimmune diseases. But the effect of miRNAs and their targeted mRNAs in acquired AA is not fully understood. <b>Methods:</b> The Gene Expression Omnibus data-sets of bone marrow T cells in acquired AA patients were performed to integrated analysis. Differently expressed miRNAs (DE-miRNAs) and mRNAs (DE-mRNAs) were identified. Target mRNAs of DE-miRNAs predicted by miRNet were compared with DE-mRNAs, the intersection mRNAs of two groups were negatively matched with the DE-miRNAs and defined as dysregulated mRNAs. GO and KEGG analyses for dysregulated mRNAs were performed. Protein–protein interaction (PPI) networks for dysregulated mRNAs were established. Modules in the PPI networks were identified, and the miRNA–mRNA networks were constructed. <b>Results:</b> 40 DE-miRNAs and 1511 DE-mRNAs were accessed. 303 negative correlation pairs of miRNA–mRNA were identified. Hsa-mir-34a-5p, hsa-mir-195-5p and hsa-mir-424-5p may be the central hubs. GO and KEGG analyses revealed that dysregulated mRNAs were involved in T cell differentiation and plasticity. Finally, the miRNA–mRNA networks were constructed. Has-mir-34a-5p, hsa-mir-195-5p and hsa-mir-424-5p were all involved in the central network and the target mRNA for them were histone genes and histone methylation gene KMT2D. <b>Conclusion:</b> The miRNA–mRNA network in our study show that hsa-mir-34a-5p, hsa-mir-195-5p, and hsa-mir-424-5p may regulate the T cell differentiation and plasticity by targeting histone gene expression and histone modification.
DOI: 10.6084/m9.figshare.12887462
title: Cost burden of breakthrough hemolysis in patients with paroxysmal nocturnal hemoglobinuria receiving ravulizumab versus eculizumab

description: <b>Objectives:</b> Although complement inhibition is highly effective, patients with paroxysmal nocturnal hemoglobinuria (PNH) may experience intravascular breakthrough hemolysis (BTH). Underlying causes may include elevated free C5, pregnancy, or non-pregnancy complement-activating conditions (e.g. infections). This study compared BTH-related resource utilization and costs in PNH patients treated with eculizumab versus ravulizumab. <b>Methods:</b> A cost model was developed using data from a targeted literature review and a survey of experienced clinicians. Costs associated with BTH episodes were calculated by cause and weighted by the proportion attributed to each cause and the cost of treating each episode. The model captured direct medical costs in 2018 US dollars. Annual BTH-related healthcare resource utilization was also calculated. <b>Results:</b> BTH episodes in the literature were commonly associated with elevated lactate dehydrogenase and aspartate aminotransferase, hemoglobinuria, transfusion needs, and/or recurrence of PNH symptoms. The majority of BTH management costs in eculizumab-treated patients related to changing from the approved dosing regimen following an episode of BTH, rather than acute management. No ongoing dosing changes were expected for ravulizumab-treated patients following episodes of BTH, substantially reducing its ongoing management costs. Resource utilization was greater for eculizumab-treated patients than ravulizumab-treated patients due to higher incidence of BTH, and risk of elevated free C5-related BTH. Total incremental cost was substantially lower for ravulizumab- vs eculizumab-treated patients ($407 vs $9379); results were consistent when pregnant women were not included ($386 vs $3472). <b>Conclusion:</b> Overall resource use and costs for BTH are estimated to be lower for PNH patients receiving ravulizumab compared with eculizumab.
DOI: 10.6084/m9.figshare.12200249
title: Identification of potential miRNA–mRNA interaction network in bone marrow T cells of acquired aplastic anemia

description: <b>Background:</b> MicroRNAs(miRNAs) can regulate T cell differentiation and plasticity by targeting their corresponding message RNAs (mRNAs), which play important roles in many autoimmune diseases. But the effect of miRNAs and their targeted mRNAs in acquired AA is not fully understood. <b>Methods:</b> The Gene Expression Omnibus data-sets of bone marrow T cells in acquired AA patients were performed to integrated analysis. Differently expressed miRNAs (DE-miRNAs) and mRNAs (DE-mRNAs) were identified. Target mRNAs of DE-miRNAs predicted by miRNet were compared with DE-mRNAs, the intersection mRNAs of two groups were negatively matched with the DE-miRNAs and defined as dysregulated mRNAs. GO and KEGG analyses for dysregulated mRNAs were performed. Protein–protein interaction (PPI) networks for dysregulated mRNAs were established. Modules in the PPI networks were identified, and the miRNA–mRNA networks were constructed. <b>Results:</b> 40 DE-miRNAs and 1511 DE-mRNAs were accessed. 303 negative correlation pairs of miRNA–mRNA were identified. Hsa-mir-34a-5p, hsa-mir-195-5p and hsa-mir-424-5p may be the central hubs. GO and KEGG analyses revealed that dysregulated mRNAs were involved in T cell differentiation and plasticity. Finally, the miRNA–mRNA networks were constructed. Has-mir-34a-5p, hsa-mir-195-5p and hsa-mir-424-5p were all involved in the central network and the target mRNA for them were histone genes and histone methylation gene KMT2D. <b>Conclusion:</b> The miRNA–mRNA network in our study show that hsa-mir-34a-5p, hsa-mir-195-5p, and hsa-mir-424-5p may regulate the T cell differentiation and plasticity by targeting histone gene expression and histone modification.
DOI: 10.15473/1635227
title: 2017 Western Passage Tidal Energy Resource Characterization Measurements

description: These data are from tidal resource characterization measurements collected between April and July 2017 in Western Passage near Eastport, Maine, USA. The dataset contains the following four sub-datasets, each of which is described in more detail in the README.pdf. 1. A bottom-mounted Teledyne RDI Workhorse 600 kHz acoustic Doppler current profiler (ADCP) was deployed at 44.92015 N, 66.98915 W in ~50 m of water from 3 April to 18 July (106 days). Data were recorded in 6-minute increments in the ENU (East, magnetic North, Up) coordinate system with bin-mapping enabled. 2. A bottom-mounted Nortek Signature 500 kHz ADCP was deployed at 44.92192 N, 66.98913 W in ~50 m of water from 4 April to 18 July (105 days). Data were sampled and recorded at 2 Hz and recorded in the ENU (East, magnetic North, Up) coordinate system. 3. Between those stations along a cross-channel transect, a Stable Tidal Turbulence Mooring (STTM) positioned ~10 m above the seabed was deployed for one week during a spring tide. The STTM was outfitted with two Nortek Vector acoustic Doppler velocimeters equipped with inertial motion units (ADVs), a bottom-tracking downward-looking Teledyne RDI Workhorse 600 kHz ADCP to provide motion-corrected flow and turbulence characteristics at high temporal resolution, and an upward-looking Teledyne RDI Sentinel V20 ADCP. The STTM was deployed at 44.92098 N, 66.98922 W from 24-31 May. 4. A vessel-mounted Teledyne RDI Workhorse 300 kHz ADCP collected current data along three transects over two days, 4-5 April. The data processing used DOLfYN version 0.11.2. All hdf5 files (i.e., files ending in `.h5`) contained here can be opened using that version of DOLfYN (e.g., `dat = dolfyn.load('')`). All distances are in meters (e.g., depth, range, MLLW, hab, eta, z_), and all velocities in m/s. See the DOLfYN documentation https://lkilcher.github.io/dolfyn/), and/or the Nortek and Teledyne RDI documentation for additional details. Additional details on the dataset can be found in the README.pdf, including: - Format details of each data file. - How to regenerate the data-processing (using the files in the `wp2017_processing.zip` archive).
DOI: 10.15121/1637460
title: Sedimentary Geothermal Feasibility Colorado Well Database

description: Well data were mined from Geothermal Prospector (GTP), Southern Methodist University (SMU), the Colorado Oil and Gas Conservation Commission (COGCC), and the Colorado Geological Survey (CGS). The well data gathered was then used to assess sedimentary geothermal feasibility in the Denver Basin, the Piceance Basin, and the Raton Basin.
DOI: 10.15121/1637461
title: Sedimentary Geothermal Feasibility in Eastern Nevada and Millard County, Utah Well Databases

description: In order to gather data to assess sedimentary geothermal feasibility in Nevada and Utah, state oil and gas and geothermal databases were serached for well files and well logs. Well data from the Nevada Bureau of Mines and Geology oil and gas and geothermal databases was mined for the following areas in Nevada: Blackburn oil field, Marys River, North Willow Creek, Tomera Ranch, and Diamond Valley, all in the Elko Basin; Bacon Flat in Railroad Valley; and Steptoe Basin. For Pavant Butte in Utah, the State of Utah Division of Oil and Gas Well File and Well Log Searches were mined for well records in Millard County. Only wells close to Pavant Butte were mined for detailed information, but all Millard County wells are included in the database. Well files were searched for temperature, permeability, pressure information, and formation depth and thickness. Temperature values are uncorrected. Locations for some wells were converted from township and range locations to approximate latitude and longitude using Google Earth and Earth Point grids to locate well pads. If no well pad could be located for a well, the center of the smallest section available (usually partsect) was used as the approximate location.
DOI: 10.15121/1638712
title: Matlab Scripts and Sample Data Associated with Water Resources Research Article

description: Scripts and data acquired at the Mirror Lake Research Site, cited by the article submitted to Water Resources Research: Distributed Acoustic Sensing (DAS) as a Distributed Hydraulic Sensor in Fractured Bedrock M. W. Becker(1), T. I. Coleman(2), and C. C. Ciervo(1) 1 California State University, Long Beach, Geology Department, 1250 Bellflower Boulevard, Long Beach, California, 90840, USA. 2 Silixa LLC, 3102 W Broadway St, Suite A, Missoula MT 59808, USA. Corresponding author: Matthew W. Becker (matt.becker@csulb.edu).
DOI: 10.15121/1642465
title: EGS Collab Modeling and Simulation Working Group Teleconference Series (1-98)

description: This submission contains the presentation slides and recordings from the first 98 EGS Collab Modeling and Simulation Working Group teleconferences. These teleconferences served three objectives for the project: 1) share simulation results, 2) communicate field activities and results to the simulation teams, and 3) hold open scientific discussions on EGS topics.
DOI: 10.15473/1643941
title: Net Shape Fabricated Low Cost MHK Pass-Through the Hub Turbine Blades with Integrated Health Management Technology

description: The primary objective of this project is to develop a three-blade MHK rotor with low manufacturing and maintenance costs. The proposed program will design, fabricate and test a novel half-scale low cost, net shape fabricated single piece three-blade MHK rotor with integrated health management technology to demonstrate significant Capital Expenditures (CAPEX) and Operational Expenditures (OPEX) cost reductions due to the novel design and manufacturing process. The proposed project is divided into three major tasks: Task 1: Single Piece Three-blade Kinetic Hydropower System (KHPS) Rotor Full-Scale and Half-Scale Design; Task 2: Composite Manufacturing Trials and Half-Scale Prototype Rotor Fabrication; and Task 3: Material Characterization and Half-Scale Prototype Test and Evaluation. These three tasks include design and analysis of full-scale and half-scale three-blade rotor prototypes using computational fluid dynamics (CFD) and finite-element analysis (FEA), demonstration of a novel half-scale net shape fabrication process, determination of a fatigue threshold composite strain allowable, three-blade rotor mold design, manufacture of half-scale rotor clam shell mold, three-blade rotor test fixture design and fabrication, development of final manufacturing and test plans, manufacture of the half-scale net shape composite single blade and three-blade prototypes, and test and evaluation of the half-scale rotor.
DOI: 10.5281/zenodo.4768787
title: Preliminary analysis shows that feral and managed honey bees in southern California have similar levels of viral pathogens - Geffre et al., 2021 - Data and Code,

description: This zip file contains the data file (viral titers from bee extracts) and R Code (as a .rmd file) used to conduct analysis for the manuscript "Preliminary analysis shows that feral and managed honey bees in southern California have similar levels of viral pathogens", but A Geffre, D Travis, J Kohn and J Nieh.
DOI: 10.5281/zenodo.4768786
title: Preliminary analysis shows that feral and managed honey bees in southern California have similar levels of viral pathogens - Geffre et al., 2021 - Data and Code,

description: This zip file contains the data file (viral titers from bee extracts) and R Code (as a .rmd file) used to conduct analysis for the manuscript "Preliminary analysis shows that feral and managed honey bees in southern California have similar levels of viral pathogens", but A Geffre, D Travis, J Kohn and J Nieh.
DOI: 10.15473/1660374
title: Wave Tank Testing Report for Controls Validation of a Heaving Point Absorber

description: The core objectives of this project is to improve the power capture of three different wave energy conversion (WEC) devices by more than 50% using an advanced control system and validate the attained improvements using wave tank and full scale testing. In parallel, we will bring along the development of a wave prediction system that is required to enable effective control and test it at full scale. The purposes of this report are to: 1. Plan and document the 1/25th scale device testing at the wave-tank facility; 2. Document the test article, setup and methodology, sensor and instrumentation, mooring, electronics, wiring, and data flow and quality assurance; 3. Communicate the testing results between the associated members; 4. Facilitate reviews that will help to ensure all aspects (risk, safety, testing procedures, etc.); 5. Provide a systematic guide to setting up, executing and decommissioning the experiment.
DOI: 10.15121/1666365
title: Fracture Sustainability Test, Pre- and Post-Test Photomicrographs

description: The primary objective of this research is to understand how different rock types, mineral and fluid compositions, and fracture surface textures determine the longevity of fracture apertures, so that selection of reservoir rock can be economically optimized to reduce future refracturing. We are performing laboratory tests to study this in a custom apparatus at conditions relevant to EGS, with temperatures up to 250 degrees C (design maximum 300 degrees C). Our approach is to perform a number of long term (up to several months) laboratory experiments using relevant rock samples with different mineralogies to explore fracture sustainability under EGS conditions. We use an apparatus that allows direct application of a normal force on the fracture faces of a single fracture in a sample having a sheared, tensile fracture. We flow brine of a specified composition through the aperture, and simultaneously measure the fracture permeability and closure. We collect the effluent water for chemical and isotopic analysis. We are numerically modeling our tests and comparing experimental and numerical results. This submission includes photomicrographs of pre-test (unreacted) and post-test (reacted) samples from Brady well BCH-03 at various depths, Desert Peak well DP 35-13, and samples of Stripa granite. The photomicrographs are provided using uncrossed and crossed polarized light (xpl). UN is uncrossed nicols, CN and xpl are crossed nicols (crossed polars). The magnification listed is just referring to the objective lens that was used, not the total magnification of the images. With a 5x objective, the bottom dimension of an image is 1.75 mm. With 10x the bottom dimension of an image is 0.875 mm, and with 2x the bottom dimension of an image is 4.375 mm.
DOI: 10.15121/1666372
title: Shear Induced Permeability Test: Brady and Desert Peak Core X-Ray CT Files

description: As part of the shear induced permeability test, the rock cores were also scanned with X-ray Computed Tomography (CT) before and after sustainability tests using a modified GE Lightspeed 16 medical CT scanner. The CT provides another perspective on the fracture and aperture, as well as the mineral distribution near the aperture. This submission includes the photos of core segments examined from Brady well BCH-03 and Desert Peak well DP 35-13. X-ray CT data is provided for the BCH-03 and DP 35-13 core segments.
DOI: 10.15121/1666375
title: Post-Test SEM Examination of Brady Core, Desert Peak Core, and Stripa Granite Samples

description: As part of the shear-induced permeability test of Brady well BCH-03, Desert Peak well DP 35-13, and Stripa granite samples, the three post-test (reacted) rock samples were examined using a Scanning Electron Microscope (SEM). The SEM images of the core and elemental analysis are included in this submission for each sample.
DOI: 10.15121/1666377
title: Magnetotelluric Data from Mountain Home, ID

description: This dataset includes magnetotelluric transfer functions in the form of EDI files for 16 stations collected by the USGS and 40 stations collected by Quantec Geoscience for Lawerence Berkeley National Lab around the Mountain Home area in Idaho. A 3D electrical resistivity model is included that images resistive and conductive bodies in the subsurface that maybe important for geothermal characterization. The model was created using ModEM using the high performance computer Yeti at the USGS.