cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.23585304
title: Supplementary Material for: Expression profile of microenvironmental factors in the interface zone of colorectal cancer: histological-stromal biomarkers and cancer cell-CAF-related proteins combined for the assessment of tumor progression

description: Introduction The characterization of tumor microenvironment (TME) related-factors and their impact on tumor progression have attracted much interest. We investigated cancer cells and CAFs to evaluate biomarkers that are associated with neoplastic progression, observing them in different interface zones of colorectal cancer. Methods On 357 CRC tissue microarrays, using immunohistochemistry, we examined the associations of podoplanin and α-SMA expressed in cancer cells and CAFs and evaluated them in different areas: tumor core, invasive front, tumor budding, tumor-stroma ratio (TSR) scoring, and desmoplastic stroma. Results CAFs expressing α-SMA were found in more than 90% of the cases. Podoplanin+ was detected in cancer cells and CAFs, with positivities of 38.6% and 70%, respectively. Higher α-SMA+ CAFs and podoplanin+ cancer cells were observed predominantly at the TSR score area: 94.3% and 64.3% of cases, respectively. The status of podoplanin in CAFs+ was higher in the desmoplastic area (71.6%). Stroma-high tumors showed increased expression of α-SMA and podoplanin in comparison with stroma-low tumors. The status of podoplanin in cancer cells was observed in association with lymphatic invasion and distant metastasis. Conclusion The substance of the CRC was composed predominantly of the surrounding stroma-α-SMA+ CAF. Podoplanin expressed in the prognosticator zones was associated with unfavorable pathological features. The combination of histologic and protein-related biomarkers can result in a tool for the stratification of patients with CRC.
DOI: 10.6084/m9.figshare.23627754
title: Supplementary Material for: Detection of abdominal lymph node metastasis from pancreatic neuroendocrine tumor by somatostatin receptor scintigraphy: Comparison with somatostatin receptors type 2 immunostaining

description: We report a 58-year-old male with a histopathological-proven grade 2 (G2) pancreatic neuroendocrine neoplasm and multiple abdominal node metastases by use of a laparoscopic pancreatic body and tail resection procedure, plus abdominal lymph node dissection. A primary pancreatic tail neuroendocrine tumor sized 20×25 mm was detected by contrast-enhanced CT, somatostatin receptor scintigraphy (SRS), and fluorodeoxyglucose positron emission tomography (FDG-PET) examinations, and pathologically diagnosed as a pancreatic neuroendocrine tumor (PNET, G2) based on positive immunostaining for somatostatin receptor (SSTR) type 2. Of three metastatic histopathological lymph nodes, two measured 18×21 and 10×12 mm, respectively, with whole strong SSTR immunostaining showing moderate uptake in SRS findings, whereas the other node, sized 8×10 mm, had strong SSTR immunostaining only in a small 6×6-mm sized portion and showed no uptake in SRS findings, likely because of the limited spatial resolution of scintigraphy. On the other hand, only the largest node (18×21 mm) was visualized by FDG-PET. SRS may be useful for metastatic lymph node diagnosis based on SSTR immunostaining, though a disadvantage is the spatial resolution limitation.
DOI: 10.6084/m9.figshare.23889780
title: ELMAS dataset

description: This dataset provides a set of 18 load profiles with an hourly temporal resolution that represent main industrial and tertiary sectors in France for the year 2018.The ELMAS dataset is derived from a total of 55,730 consumption time series initially split into 424 business sectors and three levels of subscribed capacity. The customer’s field of activity follows the Statistical Classification of Economic Activities in the European Community (NACE), which is a four-digit industry standard classification used in the European Union composed of 21 sections, 88 divisions, 272 groups, and 615 classes. For anonymity concerns, the initial times series are averaged according to their NACE coding and level of subscribed capacity.<br><br>Discrepancies between the temporal patterns of customers that belong to the same NACE section highlight the need to resort to another clustering approach. Thus, a K-means algorithm is used to gather the business groups sharing similar temporal patterns into 18 clusters. The resulting clustering shows that numerous NACE sections are scattered over various clusters, which increases the global heterogeneity of the clustering while spoiling the interpretation. The proportion of these dispersed NACE classes in terms of annual energy consumption remains low, which suggests that a manual reorganisation has little impact on the global consistency of the clusters. This manual reclassification is conducted in such a way that scattered NACE classes are gathered in the cluster that possesses the highest share of the considered NACE section. The energy consumption time series dataset represents a limited panel composed of 55,730 customers, which may bias the output load profiles in comparison with the whole French panel of industrial and tertiary customers. To fill this gap, Enedis provides the annual energy consumption of a wider range of customers for the year 2019. This annual energy consumption dataset is used to generate weights implemented in the clustering approach and to derive weighted average time series for the clusters.
DOI: 10.6084/m9.figshare.24036789
title: Supplementary Material for: Increased Glucagon Immunoreactivity in a Rat Model of Diet-induced Obesity following Sleeve Gastrectomy

description: Objective: Bariatric surgery is currently the most effective treatment for obesity, and procedures such as Roux-en Y gastric bypass and sleeve gastrectomy (SG) also result in rapid improvements in insulin sensitivity and glucose tolerance. In addition, these procedures cause changes in the secretion of various gut-derived hormones. The role these hormones play in the mechanism of the beneficial effects of bariatric surgery is still debated, but nonetheless, their importance provides inspiration for novel obesity-targeted pharmacotherapies. Methods: Male Sprague Dawley rats were fed either regular chow or a cafeteria diet to induce obesity. A sub-group of the obese animals then underwent either sham surgery or SG. Results: Following a 4-week recovery period, SG rats weighed significantly less than obese or sham-operated rats. Improvements in glucose tolerance and insulin sensitivity also occurred in the SG group, but these were not always statistically significant. We measured the intracellular lipid content of liver samples and found that obese rats showed signs of non-alcoholic fatty liver disease, which were significantly ameliorated by SG. There were significantly higher glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) responses to a standard mixed meal in the SG group, as well as paradoxically higher glucagon secretion. Conclusion: These data highlight the need for more specific anti-glucagon antibodies to characterize the changes in proglucagon-derived peptide concentrations that occur following SG. Further studies are required to determine whether these peptides contribute to the therapeutic effects of SG.
DOI: 10.6084/m9.figshare.24050169
title: Supplementary Material for: Clostridium difficile bacteremia as a rare presentation of polymicrobial pyogenic liver abscesses and its management challenges

description: Extracolonic manifestations of Clostridium difficile have been rarely reported. We herein report a case of a 60-year-old immunocompetent man presenting with fever, nausea, abdominal pain and loose stools for two weeks. Triple phase liver computed tomography demonstrated pyogenic liver abscesses and portal pylephlebitis. Blood cultures grew Clostridium difficile and Bacteroides fragilis and liver abscess cultures grew Proteus mirabilis, Escherichia coli, and the viridans group Streptococci. Antibiotics coverage was selected to direct at all identified organisms. This demonstrates an unusual case of Clostridium difficile bacteremia in a patient with polymicrobial pyogenic liver abscesses and pylephlebitis.
DOI: 10.6084/m9.figshare.24083547
title: Supplementary Material for: Symptom change during waitlist for medicated and nonmedicated patients with chronic depression

description: Introduction: Patients seeking psychotherapy often spend time on waitlist (WL), the effect of which is largely unknown. WL patients may forego alternative non-psychotherapeutic assistance and thus do more poorly than had they not been placed on a waitlist. The course of symptoms might also be influenced by use of antidepressant medication (ADM), an issue that remains unexplored in the literature. Objective: In a naturalistic setting, WL symptom change before inpatient psychotherapy (mean weeks of waiting = 22.6) was assessed in a sample (N=313) of chronically depressed patients. Methods: Using the Beck Depression Inventory-II, patients’ symptoms were tracked at assessment, when admitted to treatment (i.e., after waitlist), at post-treatment and 1-year follow-up. Multilevel growth curve analysis was used to examine wait list change for the whole sample as well as for ADM users and nonmedicated patients. Results: Symptoms were reduced significantly from assessment to admittance (Cohen´s d = .47). Symptoms reduced less for ADM users (d = .39) than for nonmedicated patients (d = .65). Conclusion: The findings indicate that chronically depressed patients experience a decrease in symptoms during waitlist, quite likely due to treatment expectations. We discuss whether less symptom improvement for ADM-users could be attributed to iatrogenic comorbidity and a higher degree of demoralization in this group.
DOI: 10.6084/m9.figshare.24173418
title: Supplementary Material for: Long-Term 5-Year Response to Pembrolizumab, Bevacizumab, and Capecitabine Regimen in a Metastatic Colon Cancer Patient with MSI-High and KRAS Mutation- Case Report

description: With an estimated 1.88 million new cases and 0.92 million deaths in 2020, colorectal cancer accounts for nearly one-tenth of all new cancer and cancer-related deaths worldwide. Nearly half of the patients of colorectal cancer are diagnosed with metastatic or inoperable disease with a very dismal 5-year survival rate. Chemotherapy, targeted therapy, and immunotherapy have been used to treat metastatic disease, either alone or in combination. We present a case of recurrent metastatic colon carcinoma with KRAS exon 2 mutation and high microsatellite instability that was treated with a combination regimen of bevacizumab, capecitabine oral chemotherapy, and pembrolizumab immunotherapy. At nearly 5 years of treatment, the patient is alive with good performance status, and improved quality of life owing to a favorable response to the molecular profiling-based treatment approach.
DOI: 10.6084/m9.figshare.22285303.v2
title: Data for: The response of wildfire regimes to Last Glacial Maximum carbon dioxide and climate

description: Data for <strong>The response of wildfire regimes to Last Glacial Maximum carbon dioxide and climate</strong>
DOI: 10.6084/m9.figshare.23607021
title: Supplementary Material for: Additional Wide Resection of Infantile Dermatofibrosarcoma Protuberans after Unplanned Excision: A Case Report

description: Dermatofibrosarcoma protuberans (DFSP) is a locally aggressive intermediate soft tissue neoplasm that occurs in the dermis. DFSP generally occurs in young to middle-aged adults and rarely in infancy. Because of its extreme rarity, DFSP is difficult to diagnose and treat, especially when it occurs in infancy. In this paper, we reported a case of infantile DFSP in which we performed additional wide resection with a 3-cm horizontal margin for a mass that had previously undergone unplanned excision. No tumor recurrence has been seen for 3 years postoperatively. We suggest that the possibility of DFSP should always be considered when an enlarging superficial mass is identified on the trunk, even in an infant. Additionally, radical local treatment is as important for DFSP in infancy as it is for DFSP in adults, even after unplanned excision.
DOI: 10.6084/m9.figshare.23716605
title: Supplementary Material for: Interferon beta-1a vs. glatiramer acetate: changes of innate immunity in a group of women with multiple sclerosis

description: Introduction: Multiple sclerosis is a chronic inflammatory autoimmune demyelinating disease that secondarily leads to the axonal loss and associated brain atrophy. Disease-modifying drugs (DMDs) have previously been studied for their ability to affect specific immunity. This study investigates the effect of interferon beta-1a (INF) and glatiramer acetate (GA) administration on changes in innate immunity cell populations. Methods: Sixty Caucasian female patients with relapsing-remitting multiple sclerosis undergo blood sample testing for 15 blood parameters at baseline, 1M, 3M and 6M after treatment by GA or IFN (started as their first line DMD). Results: A statistically significant difference in the change after 6 months was found in the parameter monocytes (relative count) in the group of patients treated with IFN. The median increase was 27.8%. Changes in many of the other 15 parameters studied were 10-20%. Conclusion: Innate immunity has long been neglected in MS immunopathology. The findings of this study show that innate immunity cells, especially monocytes may contribute significantly to MS immunopathology.
DOI: 10.6084/m9.figshare.23723337
title: Supplementary Material for: Efficacy and safety of sucroferric oxyhydroxide compared with sevelamer carbonate in Chinese dialysis patients with hyperphosphataemia: A randomised, open-label, multicentre, 12-week phase III study

description: Introduction: This study aimed to investigate the efficacy and safety of sucroferric oxyhydroxide (SFOH) vs sevelamer carbonate in controlling serum phosphorus (sP) in adult Chinese dialysis patients with hyperphosphataemia (sP &gt;1.78 mmol/L). Methods: Open-label, randomised (1:1), active-controlled, parallel group, multicentre, phase III study of SFOH and sevelamer at starting doses corresponding to 1,500 mg iron/day and 2.4 g/day, respectively, with 8-week dose titration and 4-week maintenance (NCT03644264). Primary endpoint: non-inferiority analysis of change in sP from baseline to Week 12. Secondary endpoints: sP over time and safety. Results: 415 patients screened; 286 enrolled and randomised (142 and 144 to SFOH and sevelamer, respectively). Mean (SD) baseline sP: 2.38 (0.57) and 2.38 (0.52) mmol/L, respectively. Mean (SD) change in sP from baseline to Week 12: –0.71 (0.60) vs –0.63 (0.52) mmol/L, respectively; difference (sevelamer minus SFOH) in least squares means (95% CI): 0.08 mmol/L (–0.02, 0.18) with the lower limit of 95% CI above the non-inferiority margin of –0.34 mmol/L. SFOH group achieved target sP (1.13–1.78 mmol/L) earlier than sevelamer group (56.5% vs 32.8% at Week 4) and with a lower pill burden (mean 3.7 vs 9.1 tablets/day over 4-week maintenance, respectively). Safety and tolerability of SFOH was consistent with previous studies and no new safety signals were observed. Conclusion: SFOH effectively reduced sP from baseline and was non-inferior to sevelamer after 12 weeks of treatment but had a lower pill burden in Chinese dialysis patients with hyperphosphataemia; SFOH benefit–risk profile is favourable in Chinese patients.
DOI: 10.6084/m9.figshare.23789859
title: Supplementary Material for: Large chromosome 2p duplication-associated mechanisms and clinical presentations

description: Chromosome 2p (chr2p) duplication, also known as trisomy 2p, is a rare chromosome abnormality associated with developmental delay, intellectual disability, behavioral problems, and distinctive facial features. Most of the reported cases involving trisomy 2p include additional copy number variants (CNVs) in other regions of the genome and are usually small in size. Little is known about the clinical outcomes of large duplications of chromosome 2p as the sole cytogenetic abnormality. In this study, 193 samples at the Greenwood Genetic Center (GGC) with CNVs involving chr2p were evaluated, out of which 86 had chromosome 2p duplications. Among them, eight patients were identified with large chromosome 2p duplications ranging in size from 9.3 Mb to 89 Mb, and no deletions or duplications involving other chromosomes were identified in those patients. These duplications were associated with inverted duplication, tandem duplication, and duplication as the result of translocation, with no additional CNVs identified by microarray analysis. Confirmation by conventional cytogenetics was performed in 7 of the 8 patients, and the translocations were confirmed by fluorescence in situ hybridization (FISH). Interestingly, one patient was found to have mosaic complete trisomy 2p as the result of an unbalanced de novo (X;2) chromosomal translocation. X-inactivation was skewed toward the derivative X chromosome, yet it did not appear to extend into the chromosome 2 material. Various shared clinical manifestations were observed in the individuals in this study, including developmental delay, hemifacial hypoplasia, cleft palate, and short stature, and they also have distinct features such as hypotonia, cerebellar hypogenesis, and corpus callosum agenesis, which might result from a gene dosage effect of the duplication. In conclusion, single-event large chromosome 2p duplications can result from different mechanisms, including inverted or tandem duplications within chromosome 2, or translocations involving chromosome 2 and other chromosomes. Partial or complete trisomy 2p is commonly associated with developmental delay, and additional clinical features may be related to gene dosage effects.
DOI: 10.6084/m9.figshare.23908791
title: Supplementary Material for: Translation and Adaptation of the English STORY RETELL PROCEDURE (SRP) to PORTUGUESE: A preliminary study

description: Introduction: The comprehension and production of connected language is essential to effective communication. However, few assessment and intervention programs requiring connected language have been made available in Brazilian-Portuguese. One connected language sampling procedure, the Story Retell Procedure (SRP), has been widely studied in English and primarily for people with aphasia. The SRP employs 12 stories, whose individual plots are quite different and still equivalent in terms of verbal productivity measures. The first objective of this study was to present the translation and adaptation of the SRP stories into Portuguese and to determine whether the translations are similar to English stories. The second objective was to analyze a small group of healthy adult’s responses to this assessment, thus observing whether the retellings of the SRP story forms in Portuguese would be similar to each other in the number of words, information units (IUs), and propositions – as demonstrated in English. Methods: This preliminary study translated and adapted into Portuguese, the 12 original English SRP stories. Only small cultural adaptations were made, preserving the essential content of the stories. The stories were then presented to 14 healthy adults, and the participants’ retellings from each story were compared to the other stories regarding the number of words, IUs, and propositions. Results: Few differences were found in the retellings considering the variables analyzed. Particularly, the retells of Gasolina (Gas), Biblioteca (Library) Empréstimo (Loan) Sanduíche (Sandwich), Futebol (Baseball) and Multas (Ticket) were not significantly different in the three aspects investigated in this study (percentages of words, IUs, and propositions). Discussion/Conclusion: The SRP stories adapted to Portuguese, despite having a quite close number of words, IUs, and propositions to those in the original stories, did not result in retellings with similar number of words, IUs or propositions across stories. Nonetheless, the parameters analyzed were not significantly different among the majority of the stories, and some were nearly identical. This study identified the SRP stories that can be equivalently used in assessment, reassessment, and possibly in the rehabilitation of patients with communication disorders. Likewise, differences must be considered when the stories are used with pathological populations.
DOI: 10.6084/m9.figshare.23977791
title: Supplementary Material for: Aortic stiffness is independently associated with intracranial carotid artery calcification in patients with ischemic stroke

description: Background and aims Intracranial carotid artery calcification (ICAC), as a strong contributor to the occurrence of ischemic stroke, might be present in the medial or intimal arterial layer. Traditional cardiovascular risk factors (CVRFs) are associated with ICAC; however, its association with new markers of vascular function are less understood. The paper aims to evaluate the relationship between carotid-femoral pulse wave velocity (CF-PWV) and ICAC subtypes. Methods We enrolled 65 patients with ischemic stroke. CF-PWV, systolic, diastolic, mean blood pressure, and pulse pressure (SBP, DBP, MBP, PP) were measured within 6±2 days after stroke onset, CT was performed within 24 hours. ICAC on the stroke site was classified by two methods: volume- and score-based. Tertiles of ICAC volume were determined, and low-grade ICAC (T1) was regarded as a reference. According to the score-based method, (dominant) medial and (dominant) intimal ICAC subtypes were determined. Data were analysed with multivariate logistic regression. Results Medial and intimal ICAC subtypes were found in 34 (52%) and 24 (37%) patients, respectively. In 11% of patients no ICAC calcifications were found. CF-PWV was higher in patients with high-grade ICAC (OR=1.56, 95%CI=1.03-2.35, p=0.035). CF-PWV was higher in patients with the medial ICAC subtype (OR=1.60, 95%CI=1.00-2.55, p=0.049) after adjustment for traditional CVRFs. Conclusions Our study demonstrates that among patients with ischemic stroke, aortic stiffness is independently associated with ICAC, and that medial ICAC, compared with intimal ICAC, is accompanied by more advanced aortic stiffness.
DOI: 10.6084/m9.figshare.24131667
title: Supplementary Material for: First female patient with a rare CIC¬-FOXO4 translocated sarcoma – a case report

description: Small round cell sarcoma is a group of undifferentiated malignancies arising in bone and soft tissue, notable for Ewing Sarcoma. Recently, a new World Health Organization classification has been introduced, including an additional subset of these sarcomas, named CIC rearranged sarcoma. Within this group, CIC-FOXO4 translocation is an exceedingly rare fusion that has been reported only four times in literature. Herein, we report in-depth the pathological, clinical and molecular features of a CIC-FOXO4 translocation-driven tumor in a 46 year old woman.