cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.23815420
title: Development of a novel multi-epitope vaccine based on capsid and envelope protein against Chikungunya virus

description: Chikungunya virus (CHIKV), a type A virus borne by mosquitoes that can cause major clinical manifestations including rash, fever and debilitating arthritis, grown into a reemerging serious public health issue. Currently, there is no licensed therapy or vaccine available for CHIKV, although the most promising form of treatment appears to be immunotherapy. Neutralizing antibodies for CHIKV can provide high protection for all CHIKV strains, as well as other alphaviruses. Development of a protective vaccine may be an effective strategy to prevent the outbreak of CHIKV and provide protection for travelers. In this study, we designed a multi-epitope vaccine with a 543-amino-acid structure based on the E1, E2 and capsid proteins of CHIKV, including 6 CTL epitopes, 6 HTL epitopes, 12 linear B epitopes, along with the adjuvant β-defensin III. All T-cell epitopes were docked with their corresponding MHC alleles to validate their effect on inducing immune responses, and the vaccine’s sequence was proven to have acceptable physicochemical properties. Further, the developed vaccine was docked with TLR3 and TLR8, both of which play an important role in recognizing RNA viruses. Basic analyses of the docked complexes and molecular dynamic simulations revealed that the vaccine interacted strongly with TLRs. Immunological simulations indicated that the vaccine could induce both cellular and humoral immunity. Hopefully, this proposed vaccine structure can serve as a viable candidate against CHIKV infection. Communicated by Ramaswamy H. Sarma
DOI: 10.6084/m9.figshare.23815420.v1
title: Development of a novel multi-epitope vaccine based on capsid and envelope protein against Chikungunya virus

description: Chikungunya virus (CHIKV), a type A virus borne by mosquitoes that can cause major clinical manifestations including rash, fever and debilitating arthritis, grown into a reemerging serious public health issue. Currently, there is no licensed therapy or vaccine available for CHIKV, although the most promising form of treatment appears to be immunotherapy. Neutralizing antibodies for CHIKV can provide high protection for all CHIKV strains, as well as other alphaviruses. Development of a protective vaccine may be an effective strategy to prevent the outbreak of CHIKV and provide protection for travelers. In this study, we designed a multi-epitope vaccine with a 543-amino-acid structure based on the E1, E2 and capsid proteins of CHIKV, including 6 CTL epitopes, 6 HTL epitopes, 12 linear B epitopes, along with the adjuvant β-defensin III. All T-cell epitopes were docked with their corresponding MHC alleles to validate their effect on inducing immune responses, and the vaccine’s sequence was proven to have acceptable physicochemical properties. Further, the developed vaccine was docked with TLR3 and TLR8, both of which play an important role in recognizing RNA viruses. Basic analyses of the docked complexes and molecular dynamic simulations revealed that the vaccine interacted strongly with TLRs. Immunological simulations indicated that the vaccine could induce both cellular and humoral immunity. Hopefully, this proposed vaccine structure can serve as a viable candidate against CHIKV infection. Communicated by Ramaswamy H. Sarma
DOI: 10.6084/m9.figshare.11756796
title: Anti-placental growth factor antibody ameliorates hyperoxia-mediated impairment of lung development in neonatal rats

description: This study investigates the effect of the overexpression of the placental growth factor (PGF) and hyperoxia on lung development and determines whether anti-PGF antibody ameliorates hyperoxia-mediated impairment of lung development in newborn rats. After exposure to normoxic conditions for seven days, newborn rats subjected to normoxia were intraperitoneally or intratracheally injected with physiological saline, adenovirus-negative control (Ad-NC), or adenovirus-PGF (Ad-PGF) to create the Normoxia, Normoxia+Ad-NC, and Normoxia+Ad-PGF groups, respectively. Newborn rats subjected to hyperoxia were intraperitoneally injected with physiological saline or anti-PGF antibodies to create the Hyperoxia and Hyperoxia+anti-PGF groups, respectively. Our results revealed significant augmentation in the levels of PGF and its receptor Flt-1 in the lung tissues of newborn rats belonging to the Normoxia+Ad-PGF or Hyperoxia groups. PGF overexpression in these groups caused lung injury in newborn rats, while anti-PGF antibody treatment significantly cured the hyperoxia-induced lung injury. Moreover, PGF overexpression significantly increased TNF-α and Il-6 levels in the bronchoalveolar lavage (BAL) fluid of the Normoxia+Ad-PGF and Hyperoxia groups. However, their levels were significantly reduced in the BAL fluid of the Hyperoxia+anti-PGF group. Immunohistochemical analysis revealed that PGF overexpression and hyperoxia treatment significantly increased the expression of the angiogenesis marker, CD34. However, its expression was significantly decreased upon administration of anti-PGF antibodies (compared to the control group under hyperoxia). In conclusion, PGF overexpression impairs lung development in newborn rats while its inhibition using an anti-PGF antibody ameliorates the same. These results provided new insights for the clinical management of bronchopulmonary dysplasia in premature infants.
DOI: 10.6084/m9.figshare.11756796.v1
title: Anti-placental growth factor antibody ameliorates hyperoxia-mediated impairment of lung development in neonatal rats

description: This study investigates the effect of the overexpression of the placental growth factor (PGF) and hyperoxia on lung development and determines whether anti-PGF antibody ameliorates hyperoxia-mediated impairment of lung development in newborn rats. After exposure to normoxic conditions for seven days, newborn rats subjected to normoxia were intraperitoneally or intratracheally injected with physiological saline, adenovirus-negative control (Ad-NC), or adenovirus-PGF (Ad-PGF) to create the Normoxia, Normoxia+Ad-NC, and Normoxia+Ad-PGF groups, respectively. Newborn rats subjected to hyperoxia were intraperitoneally injected with physiological saline or anti-PGF antibodies to create the Hyperoxia and Hyperoxia+anti-PGF groups, respectively. Our results revealed significant augmentation in the levels of PGF and its receptor Flt-1 in the lung tissues of newborn rats belonging to the Normoxia+Ad-PGF or Hyperoxia groups. PGF overexpression in these groups caused lung injury in newborn rats, while anti-PGF antibody treatment significantly cured the hyperoxia-induced lung injury. Moreover, PGF overexpression significantly increased TNF-α and Il-6 levels in the bronchoalveolar lavage (BAL) fluid of the Normoxia+Ad-PGF and Hyperoxia groups. However, their levels were significantly reduced in the BAL fluid of the Hyperoxia+anti-PGF group. Immunohistochemical analysis revealed that PGF overexpression and hyperoxia treatment significantly increased the expression of the angiogenesis marker, CD34. However, its expression was significantly decreased upon administration of anti-PGF antibodies (compared to the control group under hyperoxia). In conclusion, PGF overexpression impairs lung development in newborn rats while its inhibition using an anti-PGF antibody ameliorates the same. These results provided new insights for the clinical management of bronchopulmonary dysplasia in premature infants.
DOI: 10.6084/m9.figshare.11756805
title: Pitting Corrosion of Thermally Aged Duplex Stainless Steels at Different Temperature for Long Time

description: The pitting corrosion of three duplex steels (DSS), SAF2205, SAF2507, Z3CN20.09M thermally aged at 350 - 500 ℃ for 5500 h was investigated by the means of electrochemical techniques. The pitting potential (Ep) of thermally aged Z3CN20.09M specimens decreased with increasing of ageing temperature, however, the Ep of SAF2205 and SAF2507 thermally aged specimens decreased first and reached the lowest value at 450 ℃ and then increased slightly. The electrochemical impedance spectroscopy results are coincident with the potentiodynamic polarisation testing results. The variation in the charge transfer resistance of specimens coincided with the Ep values. There is little influence of low temperature (below 350 ℃) on resistance to pitting of SAF2205 and SAF2507 DSS. But, the pitting resistance of them degrades drastically ageing at higher temperature above 450 ℃. The deterioration in pitting resistance of thermally aged DSS specimens mainly attributes to the precipitation of Cr-rich α′ phases which affected by temperature markedly. At the range of 350 -500 ℃, the temperature the higher, the precipitation of Cr-rich α′ phases the more. The formation of G phases and the healing process during the long thermal ageing at 500 ℃ is the other reasons for the change in pitting resistance.
DOI: 10.6084/m9.figshare.11756805.v1
title: Pitting Corrosion of Thermally Aged Duplex Stainless Steels at Different Temperature for Long Time

description: The pitting corrosion of three duplex steels (DSS), SAF2205, SAF2507, Z3CN20.09M thermally aged at 350 - 500 ℃ for 5500 h was investigated by the means of electrochemical techniques. The pitting potential (Ep) of thermally aged Z3CN20.09M specimens decreased with increasing of ageing temperature, however, the Ep of SAF2205 and SAF2507 thermally aged specimens decreased first and reached the lowest value at 450 ℃ and then increased slightly. The electrochemical impedance spectroscopy results are coincident with the potentiodynamic polarisation testing results. The variation in the charge transfer resistance of specimens coincided with the Ep values. There is little influence of low temperature (below 350 ℃) on resistance to pitting of SAF2205 and SAF2507 DSS. But, the pitting resistance of them degrades drastically ageing at higher temperature above 450 ℃. The deterioration in pitting resistance of thermally aged DSS specimens mainly attributes to the precipitation of Cr-rich α′ phases which affected by temperature markedly. At the range of 350 -500 ℃, the temperature the higher, the precipitation of Cr-rich α′ phases the more. The formation of G phases and the healing process during the long thermal ageing at 500 ℃ is the other reasons for the change in pitting resistance.
DOI: 10.6084/m9.figshare.11756853
title: Aliskiren attenuates cardiac dysfunction by modulation of the mTOR and apoptosis pathways

description: Aliskiren (ALS) is well known for its antihypertensive properties. However, the potential underlying the molecular mechanism and the anti-hypertrophic effect of ALS have not yet been fully elucidated. The aim of the present study was to investigate the role of ALS in mammalian target of rapamycin (mTOR) and apoptosis signaling using in vivo and in vitro models of cardiac hypertrophy. A rat model of cardiac hypertrophy was induced by isoproterenol treatment (5 mg·kg-1·day-1) for 4 weeks, with or without ALS treatment at 20 mg·kg-1·day-1. The expression of hypertrophic, fibrotic, and apoptotic markers was determined by RT-qPCR. The protein expression of apoptotic markers mTOR and p-mTOR was assessed by western blot analysis. The proliferation of H9C2 cells was monitored using the MTS assay. Cell apoptosis was analyzed using flow cytometry. In vivo, isoproterenol-treated rats exhibited worse cardiac function, whereas ALS treatment reversed these dysfunctions, which were associated with changes in p-mTOR, Bcl-2, Bax, and cleaved caspase-3 expression, as well as the number of apoptotic cells. In vitro, H9C2 cardiomyocyte viability was significantly inhibited and cardiac hypertrophy was induced by Ang II administration, but ALS reversed Ang II-induced H9C2 cardiomyocyte hypertrophy and death. Furthermore, Ang II triggered the activation of the mTOR and apoptosis pathways in hypertrophic cardiomyocytes that were inhibited by ALS treatment. These results indicated that ALS alleviated cardiac hypertrophy through inhibition of the mTOR and apoptosis pathways in cardiomyocytes.
DOI: 10.6084/m9.figshare.11756853.v1
title: Aliskiren attenuates cardiac dysfunction by modulation of the mTOR and apoptosis pathways

description: Aliskiren (ALS) is well known for its antihypertensive properties. However, the potential underlying the molecular mechanism and the anti-hypertrophic effect of ALS have not yet been fully elucidated. The aim of the present study was to investigate the role of ALS in mammalian target of rapamycin (mTOR) and apoptosis signaling using in vivo and in vitro models of cardiac hypertrophy. A rat model of cardiac hypertrophy was induced by isoproterenol treatment (5 mg·kg-1·day-1) for 4 weeks, with or without ALS treatment at 20 mg·kg-1·day-1. The expression of hypertrophic, fibrotic, and apoptotic markers was determined by RT-qPCR. The protein expression of apoptotic markers mTOR and p-mTOR was assessed by western blot analysis. The proliferation of H9C2 cells was monitored using the MTS assay. Cell apoptosis was analyzed using flow cytometry. In vivo, isoproterenol-treated rats exhibited worse cardiac function, whereas ALS treatment reversed these dysfunctions, which were associated with changes in p-mTOR, Bcl-2, Bax, and cleaved caspase-3 expression, as well as the number of apoptotic cells. In vitro, H9C2 cardiomyocyte viability was significantly inhibited and cardiac hypertrophy was induced by Ang II administration, but ALS reversed Ang II-induced H9C2 cardiomyocyte hypertrophy and death. Furthermore, Ang II triggered the activation of the mTOR and apoptosis pathways in hypertrophic cardiomyocytes that were inhibited by ALS treatment. These results indicated that ALS alleviated cardiac hypertrophy through inhibition of the mTOR and apoptosis pathways in cardiomyocytes.
DOI: 10.6084/m9.figshare.11756889
title: Chemical composition and larvicidal activities of essential oil of Cinnamomum camphora (L.) leaf against Anopheles stephensi

description: Abstract INTRODUCTION Anopheles stephensi is the main malaria vector in Southeast Asia. Recently, plant-sourced larvicides are attracting great interests. METHODS: The essential oil was extracted from the leaf of Cinnamomum camphora (L.), and a bioassay was conducted to determine the larvicidal efficacy. The chemical composition of the essential oil was determined by GC-MS analysis. RESULTS: The oil showed strong, dose-dependent larvicidal activities. The onset of larvicidal efficiency was rapid. The LC50 and LC95 were determined as 0.146% and 1.057% at 1 h, 0.031% and 0.237% at 12 h, 0.026% and 0.128% at 24 h, respectively. The oil contains 32 compounds. CONCLUSIONS The essential oil of C. camphora leaf has an excellent larvicidal potential for the control of A. stephensi.
DOI: 10.6084/m9.figshare.11756889.v1
title: Chemical composition and larvicidal activities of essential oil of Cinnamomum camphora (L.) leaf against Anopheles stephensi

description: Abstract INTRODUCTION Anopheles stephensi is the main malaria vector in Southeast Asia. Recently, plant-sourced larvicides are attracting great interests. METHODS: The essential oil was extracted from the leaf of Cinnamomum camphora (L.), and a bioassay was conducted to determine the larvicidal efficacy. The chemical composition of the essential oil was determined by GC-MS analysis. RESULTS: The oil showed strong, dose-dependent larvicidal activities. The onset of larvicidal efficiency was rapid. The LC50 and LC95 were determined as 0.146% and 1.057% at 1 h, 0.031% and 0.237% at 12 h, 0.026% and 0.128% at 24 h, respectively. The oil contains 32 compounds. CONCLUSIONS The essential oil of C. camphora leaf has an excellent larvicidal potential for the control of A. stephensi.
DOI: 10.6084/m9.figshare.7558286.v1
title: Additional file 2: of Molecular changes during extended neoadjuvant letrozole treatment of breast cancer: distinguishing acquired resistance from dormant tumours

description: Table S1. Table indicating with which public dataset each sample is associated. Table S2. Differentially expressed genes between long-term treated and pre-treatment dormant tumours. Table S3. Enriched pathways for differentially expressed genes between long-term treated and pre-treatment dormant tumours. Table S4. Differentially expressed genes between long-term treated and pre-treatment acquired resistant tumours. Table S5. Enriched pathways for differentially expressed genes between long-term treated and pre-treatment acquired resistant tumours. Table S6. Differentially expressed genes between long-term treated dormant and resistant tumours. Table S7. Enriched pathways for differentially expressed genes between long-term treated dormant and resistant tumours. Table S8. Differentially expressed proteins between long-term treated dormant and resistant tumours. (XLSX 286 kb)
DOI: 10.6084/m9.figshare.19092663.v1
title: Additional file 2 of Differences in caecal microbiota composition and Salmonella carriage between experimentally infected inbred lines of chickens

description: Additional file 2. Metadata associated with all samples.
DOI: 10.6084/m9.figshare.19092666.v1
title: Additional file 3 of Differences in caecal microbiota composition and Salmonella carriage between experimentally infected inbred lines of chickens

description: Additional file 3. Unrarefied operational taxonomic unit table.
DOI: 10.6084/m9.figshare.19092634
title: Additional file 1 of LINC01119 negatively regulates osteogenic differentiation of mesenchymal stem cells via the Wnt pathway by targeting FZD4

description: Additional file 1. The data of differentially expressed genes (DEGs) in osteogenic differentiation of MSC at 12h with that at 0 h. the result identified 592 DEGs in this group.
DOI: 10.5281/zenodo.13382780
title: 3D Real-Time Single Particle Tracking using two-photon fluorescence from bright dye-based organic nanoparticles

description: Data set, and attached ReadMe files related to the production of the figures in the article "3D Real-Time Single Particle Tracking using two-photon fluorescence from bright dye-based organic nanoparticles"  by Emperauger et al.

 

The ReadMe files explaining how each data file is organised, the data are in txt format, organised by figure and sub-figures and compressed.
DOI: 10.5281/zenodo.13382781
title: 3D Real-Time Single Particle Tracking using two-photon fluorescence from bright dye-based organic nanoparticles

description: Data set, and attached ReadMe files related to the production of the figures in the article "3D Real-Time Single Particle Tracking using two-photon fluorescence from bright dye-based organic nanoparticles"  by Emperauger et al.

 

The ReadMe files explaining how each data file is organised, the data are in txt format, organised by figure and sub-figures and compressed.
DOI: 10.14272/khufhlfhoqvfgb-uhfffaoysa-n/chmo0000596
title: distortionless enhancement with polarization transfer (DEPT) (1-aminoanthracene-9,10-dione)
title: InChI=1S/C14H9NO2/c15-11-7-3-6-10-12(11)14(17)9-5-2-1-4-8(9)13(10)16/h1-7H,15H2

description: dataset for distortionless enhancement with polarization transfer (DEPT)
DOI: 10.14272/khufhlfhoqvfgb-uhfffaoysa-n/chmo0000593
title: 1H nuclear magnetic resonance spectroscopy (1H NMR) (1-aminoanthracene-9,10-dione)
title: InChI=1S/C14H9NO2/c15-11-7-3-6-10-12(11)14(17)9-5-2-1-4-8(9)13(10)16/h1-7H,15H2

description: dataset for 1H nuclear magnetic resonance spectroscopy (1H NMR)
DOI: 10.14272/khufhlfhoqvfgb-uhfffaoysa-n/chmo0000596.1
title: distortionless enhancement with polarization transfer (DEPT) (1-aminoanthracene-9,10-dione)
title: InChI=1S/C14H9NO2/c15-11-7-3-6-10-12(11)14(17)9-5-2-1-4-8(9)13(10)16/h1-7H,15H2

description: dataset for distortionless enhancement with polarization transfer (DEPT)
DOI: 10.14272/khufhlfhoqvfgb-uhfffaoysa-n/chmo0000595
title: 13C nuclear magnetic resonance spectroscopy (13C NMR) (1-aminoanthracene-9,10-dione)
title: InChI=1S/C14H9NO2/c15-11-7-3-6-10-12(11)14(17)9-5-2-1-4-8(9)13(10)16/h1-7H,15H2

description: dataset for 13C nuclear magnetic resonance spectroscopy (13C NMR)
DOI: 10.14272/khufhlfhoqvfgb-uhfffaoysa-n/chmo0000601
title: heteronuclear multiple bond coherence (HMBC) (1-aminoanthracene-9,10-dione)
title: InChI=1S/C14H9NO2/c15-11-7-3-6-10-12(11)14(17)9-5-2-1-4-8(9)13(10)16/h1-7H,15H2

description: dataset for heteronuclear multiple bond coherence (HMBC)
DOI: 10.14272/khufhlfhoqvfgb-uhfffaoysa-n.1
title: 1-aminoanthracene-9,10-dione
title: InChI=1S/C14H9NO2/c15-11-7-3-6-10-12(11)14(17)9-5-2-1-4-8(9)13(10)16/h1-7H,15H2

description: This is a physical chemical entity[CHEBI_24431] associated with a molecule[CHEBI_25367].
 The molecule[CHEBI_25367] can be described by the following structural desciptors[cheminf_000085]:
 InChI descriptor[cheminf_000113]: InChI=1S/C14H9NO2/c15-11-7-3-6-10-12(11)14(17)9-5-2-1-4-8(9)13(10)16/h1-7H,15H2, and canonical SMILES descriptor[cheminf_000007]: Nc1cccc2c1C(=O)c1ccccc1C2=O, and by the IUPAC name[cheminf_000107]: 1-aminoanthracene-9,10-dione.
 
 The physical chemical entity[CHEBI_24431] has a component solvent[CHEBI_46787] which is described by the canonical SMILES descriptor[cheminf_000007]:
 
 The physical chemical entity[CHEBI_24431] has the following Sample ID as registered in the research data repository chemotion (www.chemotion-repository.net, https://doi.org/10.25504/FAIRsharing.iagXcR): CRS-41829

 The physical chemical entity[CHEBI_24431] can be described by the physical descriptors [CHEMINF_000025]:
 Melting point descriptor[CHEMINF_000256]: 
 Boiling point descriptor[CHEMINF_000257]: 
 Refractive index descriptor[CHEMINF_000253]:

 The physical chemical entity[CHEBI_24431] can be further described by the following assays[OBI:0000070][CHMO:0001133]:
 
 CHMO:0000604 | heteronuclear single quantum coherence (HSQC)
 
 CHMO:0000596 | distortionless enhancement with polarization transfer (DEPT)
 
 CHMO:0000601 | heteronuclear multiple bond coherence (HMBC)
 
 CHMO:0000596 | distortionless enhancement with polarization transfer (DEPT)
 
 CHMO:0000599 | correlation spectroscopy (COSY)
 
 CHMO:0000593 | 1H nuclear magnetic resonance spectroscopy (1H NMR)
 
 CHMO:0000595 | 13C nuclear magnetic resonance spectroscopy (13C NMR)
 
 The physical chemical entity[CHEBI_24431] was deposited to the Molecule Archive of the Karlsruhe Insitute of Technology (KIT) with the following Sample ID: 

 Used ontologies:
 CHEBI - Chemical Entities of Biological Interest
 CHEMINF - chemical information ontology (information entities about chemical entities)
 CHMO - Chemical Methods Ontology
 OBI - Ontology for Biomedical Investigations
DOI: 10.14272/khufhlfhoqvfgb-uhfffaoysa-n/chmo0000599
title: correlation spectroscopy (COSY) (1-aminoanthracene-9,10-dione)
title: InChI=1S/C14H9NO2/c15-11-7-3-6-10-12(11)14(17)9-5-2-1-4-8(9)13(10)16/h1-7H,15H2

description: dataset for correlation spectroscopy (COSY)
DOI: 10.14272/khufhlfhoqvfgb-uhfffaoysa-n/chmo0000604
title: heteronuclear single quantum coherence (HSQC) (1-aminoanthracene-9,10-dione)
title: InChI=1S/C14H9NO2/c15-11-7-3-6-10-12(11)14(17)9-5-2-1-4-8(9)13(10)16/h1-7H,15H2

description: dataset for heteronuclear single quantum coherence (HSQC)
DOI: 10.15468/dl.u7yj24
title: Occurrence Download

description: A dataset containing 2346 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Prionailurus bengalensis (Kerr, 1792)"
 ]
}

 The dataset includes 2346 records from 90 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0105974-240626123714530/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.4k7t6g
title: Occurrence Download

description: A dataset containing 6434 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Kalanchoe delagoensis Eckl. & Zeyh."
 ]
}

 The dataset includes 6434 records from 227 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0105975-240626123714530/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.