cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.5812782
title: Supplementary Material for: Danhong Injection Protects Against Hypertension-Induced Renal Injury Via Down-Regulation of Myoglobin Expression in Spontaneously Hypertensive Rats

description: <b><i>Background/Aims:</i></b> High blood pressure is a major risk factor for chronic kidney disease. Currently, single-target anti-hypertensive drugs are not designed for high blood pressure-related organ damages. Danhong injection (DHI), made from the aqueous extracts of <i>Radix Salviae miltiorrhizae</i> and <i>Flos Carthamus tinctorius</i>, has various pharmacological effects, including BP lowering in SHR, mediated by the reduction of vascular remodeling and the up-regulation of Kallikrein-kinin system published recently by our team, yet if it renders renal protection remains unknown. The current study demonstrated a protective role of DHI in renal injury caused by hypertension and identified its molecular targets in the kidney of spontaneously hypertensive rats (SHR). <b><i>Methods:</i></b> Adult SHR and age/gender-matched normotensive Wistar-Kyoto (WKY) rats were treated with DHI, Losartan, or saline for 4 weeks. Serum levels of Creatinine (CRE), Micro-albumin (mAlb), Beta2-microglobulin (β2-MG), and Uric acid (UA) were detected using ELISA kits. Renal pathology was examined by hematoxylin and Eosin (H&E) stains. Microarray analysis was performed on kidney tissues, and gene expression changes were validated by quantitative reverse transcription polymerase chain reaction (qRT-PCR) and Western blot analyses. <b><i>Results:</i></b> Renal histopathological scores showed that SHR exhibited serious kidney injury compared to normotensive WKY rats. The intervention with DHI potently suppressed the renal injury biomarker (KIM-1) and kidney lesions compared to the untreated hypertensive subjects. Microarray analysis revealed that among the 124 genes that were differentially expressed by DHI treatment in SHR kidney, down-regulation of renal myoglobin (Mb) gene was the most prominent and was subsequently confirmed by qRT-PCR and Western blot analysis. <b><i>Conclusion:</i></b> Hypertension-induced renal injury in SHR may be alleviated by DHI in part by local suppression of Kidney injury molecule-1 and down-regulation of Myoglobin. However, if this effect is independent of the known anti-hypertensive action of DHI in blood vessel remains to be determined.
DOI: 10.6084/m9.figshare.5812782.v1
title: Supplementary Material for: Danhong Injection Protects Against Hypertension-Induced Renal Injury Via Down-Regulation of Myoglobin Expression in Spontaneously Hypertensive Rats

description: <b><i>Background/Aims:</i></b> High blood pressure is a major risk factor for chronic kidney disease. Currently, single-target anti-hypertensive drugs are not designed for high blood pressure-related organ damages. Danhong injection (DHI), made from the aqueous extracts of <i>Radix Salviae miltiorrhizae</i> and <i>Flos Carthamus tinctorius</i>, has various pharmacological effects, including BP lowering in SHR, mediated by the reduction of vascular remodeling and the up-regulation of Kallikrein-kinin system published recently by our team, yet if it renders renal protection remains unknown. The current study demonstrated a protective role of DHI in renal injury caused by hypertension and identified its molecular targets in the kidney of spontaneously hypertensive rats (SHR). <b><i>Methods:</i></b> Adult SHR and age/gender-matched normotensive Wistar-Kyoto (WKY) rats were treated with DHI, Losartan, or saline for 4 weeks. Serum levels of Creatinine (CRE), Micro-albumin (mAlb), Beta2-microglobulin (β2-MG), and Uric acid (UA) were detected using ELISA kits. Renal pathology was examined by hematoxylin and Eosin (H&E) stains. Microarray analysis was performed on kidney tissues, and gene expression changes were validated by quantitative reverse transcription polymerase chain reaction (qRT-PCR) and Western blot analyses. <b><i>Results:</i></b> Renal histopathological scores showed that SHR exhibited serious kidney injury compared to normotensive WKY rats. The intervention with DHI potently suppressed the renal injury biomarker (KIM-1) and kidney lesions compared to the untreated hypertensive subjects. Microarray analysis revealed that among the 124 genes that were differentially expressed by DHI treatment in SHR kidney, down-regulation of renal myoglobin (Mb) gene was the most prominent and was subsequently confirmed by qRT-PCR and Western blot analysis. <b><i>Conclusion:</i></b> Hypertension-induced renal injury in SHR may be alleviated by DHI in part by local suppression of Kidney injury molecule-1 and down-regulation of Myoglobin. However, if this effect is independent of the known anti-hypertensive action of DHI in blood vessel remains to be determined.
DOI: 10.6084/m9.figshare.5812776
title: Geo-tagged street level imagery collection set-up

description: Description of a mount to collect field data.
DOI: 10.6084/m9.figshare.5812764.v1
title: EEG_Auditory_Oddball_Preprocessed_Data

description: This dataset was obtained at the Queensland Brain Institute, Australia, using a 64 channel EEG Biosemi system. 21 healthy participants completed an auditory oddball paradigm (as described in Garrido et al., 2017).<br>For a description of the oddball paradigm, please see Garrido et al., 2017:Garrido, M.I., Rowe, E.G., Halasz, V., & Mattingley, J. (2017). Bayesian mapping reveals that attention boosts neural responses to predicted and unpredicted stimuli. Cerebral Cortex, 1-12. DOI: 10.1093/cercor/bhx087<br>If you use this dataset, please cite its doi, as well as citing the associated methods paper, which is as follows:Harris, C.D., Rowe, E.G., Randeniya, R. and Garrido, M.I. (2018). Bayesian Model Selection Maps for group studies using M/EEG data.<br>For scripts to analyse the data, please see: https://github.com/ClareDiane/BMS4EEG<br>
DOI: 10.6084/m9.figshare.5812758
title: Asymmetric <i>N</i>-heterocyclic carbene benzimidazolium salts and their silver(I) complexes: potential as ionic liquid crystals

description: The synthesis and characterisation of a homologous series of monodentate benzimidazolium salts, <b>1</b>–<b>4</b> and their mononuclear silver(I)–NHC (where NHC = <i>N</i>-heterocyclic carbene) complexes, <b>5</b>–<b>8,</b> are reported. The benzimidazolium salts were prepared from the <i>N</i>-alkylation of 1-methyl-benzimidazole with alkyl halides of varying carbon chain lengths. The mono silver(I)-NHC complexes, <b>5</b>–<b>8,</b> were prepared by the reaction of the benzimidazolium salts with Ag<sub>2</sub>O. All the synthesised compounds were fully characterised by <sup>1</sup>H-nuclear magnetic resonance (<sup>1</sup>H-NMR), <sup>13</sup>C-NMR and fourier-transform infrared (FTIR) spectroscopy. The molecular structures of compounds <b>3</b>·PF<sub>6</sub>, <b>4</b>·PF<sub>6</sub>, <b>7</b> and <b>8</b> were elucidated through single-crystal X-ray diffraction analyses. We postulate that the attachment of long alkyl chains to the heterocyclic core of 1-methyl benzimidazole could induce mesophase formation. The liquid crystalline behaviour of the benzimidazolium salts was investigated by polarised optical microscope and differential scanning calorimetry. Salts <b>3</b> and <b>4</b> were found to be thermotropic liquid crystals which exhibited a smectic A phase. However, upon complexation with silver(I) ions, all the Ag(I)–NHC complexes are found to be non-mesogenic.
DOI: 10.6084/m9.figshare.5812758.v1
title: Asymmetric <i>N</i>-heterocyclic carbene benzimidazolium salts and their silver(I) complexes: potential as ionic liquid crystals

description: The synthesis and characterisation of a homologous series of monodentate benzimidazolium salts, <b>1</b>–<b>4</b> and their mononuclear silver(I)–NHC (where NHC = <i>N</i>-heterocyclic carbene) complexes, <b>5</b>–<b>8,</b> are reported. The benzimidazolium salts were prepared from the <i>N</i>-alkylation of 1-methyl-benzimidazole with alkyl halides of varying carbon chain lengths. The mono silver(I)-NHC complexes, <b>5</b>–<b>8,</b> were prepared by the reaction of the benzimidazolium salts with Ag<sub>2</sub>O. All the synthesised compounds were fully characterised by <sup>1</sup>H-nuclear magnetic resonance (<sup>1</sup>H-NMR), <sup>13</sup>C-NMR and fourier-transform infrared (FTIR) spectroscopy. The molecular structures of compounds <b>3</b>·PF<sub>6</sub>, <b>4</b>·PF<sub>6</sub>, <b>7</b> and <b>8</b> were elucidated through single-crystal X-ray diffraction analyses. We postulate that the attachment of long alkyl chains to the heterocyclic core of 1-methyl benzimidazole could induce mesophase formation. The liquid crystalline behaviour of the benzimidazolium salts was investigated by polarised optical microscope and differential scanning calorimetry. Salts <b>3</b> and <b>4</b> were found to be thermotropic liquid crystals which exhibited a smectic A phase. However, upon complexation with silver(I) ions, all the Ag(I)–NHC complexes are found to be non-mesogenic.
DOI: 10.6084/m9.figshare.5812746
title: Figures for a Paper on a Fokker-Planck Equation

description: Figures for a paper on a time-dependent Fokker-Planck equation along with related files generating them.
DOI: 10.6084/m9.figshare.5812746.v2
title: Figures for a Paper on a Fokker-Planck Equation

description: Figures for a paper on a time-dependent Fokker-Planck equation along with related files generating them.
DOI: 10.6084/m9.figshare.5812746.v1
title: Figures for a Paper on a Fokker-Planck Equation

description: Figures for a paper on a time-dependent Fokker-Planck equation along with related files generating them.
DOI: 10.6084/m9.figshare.5812716
title: The FCS-like zinc finger scaffold of the kinase SnRK1 is formed by the coordinated actions of the FLZ domain and intrinsically disordered regions

description: Computational prediction
DOI: 10.6084/m9.figshare.5812716.v1
title: The FCS-like zinc finger scaffold of the kinase SnRK1 is formed by the coordinated actions of the FLZ domain and intrinsically disordered regions

description: Computational prediction
DOI: 10.6084/m9.figshare.5812710
title: Human list of counts after hypoxic stress by RNA-seq (up/down/unchanged)

description: The number of experiments in which gene was up/down regulated was counted for all genes in human utilizing RNA-seq data collected. For up/down regulated gene selection, over 2 fold (formerly 1.5 fold in version1) threshold was adopted.
DOI: 10.6084/m9.figshare.5812710.v1
title: Human list of counts after hypoxic stress by RNA-seq (up/down/unchanged)

description: The number of experiments in which gene was up/down regulated was counted for all genes in human utilizing RNA-seq data collected. For up/down regulated gene selection, over 1.5 fold threshold was adopted.
DOI: 10.6084/m9.figshare.5812710.v2
title: Human list of counts after hypoxic stress by RNA-seq (up/down/unchanged)

description: The number of experiments in which gene was up/down regulated was counted for all genes in human utilizing RNA-seq data collected. For up/down regulated gene selection, over 2 fold (formerly 1.5 fold in version1) threshold was adopted.
DOI: 10.6084/m9.figshare.5812707
title: Economic burden of varicella in children 1–12 years of age in Argentina, 2009–2014

description: <b>Background:</b> In Argentina, varicella vaccination was included in the national schedule for mandatory immunizations in 2015. The vaccine has been shown to substantially reduce the morbidity and mortality associated with the virus. The purpose of this study was to evaluate the clinical and economic burden associated with varicella in Argentina prior to vaccine introduction. <b>Methods:</b> This was a multi-center, retrospective chart review study among patients aged 1–12 years with a primary varicella diagnosis in 2009–2014 in Argentina. Healthcare resource utilization (HCRU) associated with varicella and its complications, unit costs, and work loss were used to estimate direct and indirect costs. All costs are presented in 2015 United States dollars (USD). <b>Results:</b> One hundred and fifty children with varicella were included (75 outpatients, 75 inpatients), with a mean age of 3.8 (SD = 2.4) and 2.9 (SD = 2.2) years, respectively. One or more complications were experienced by 28.0% of outpatients and 98.7% of inpatients, the most common being skin and soft tissue infections, pneumonia, sepsis, cerebellitis, and febrile seizure. HCRU estimates included use of over-the-counter (OTC) medications (58.7% outpatients, 94.7% inpatients), prescription medications (26.7% outpatients, 77.3% inpatients), tests/procedures (13.3% outpatients, 70.7% inpatients), and consultation with allied health professionals (1.3% outpatients, 32.0% inpatients). The average duration of hospital stay was 4.9 (95% CI = 4.2–5.7) days, and the average duration of ICU stay was 4.8 (95% CI = 1.6–14.1) days. The total combined direct and indirect cost per varicella case was 2947.7 USD (inpatients) and 322.7 USD (outpatients). The overall annual cost of varicella in Argentina for children aged ≤14 years in 2015 was estimated at 40,054,378.0 USD. <b>Conclusion:</b> The clinical burden of varicella in Argentina was associated with utilization of significant amounts of healthcare resources, resulting in substantial economic costs. These costs should be reduced with the recent implementation of routine vaccination of children.
DOI: 10.6084/m9.figshare.5812707.v1
title: Economic burden of varicella in children 1-12 years of age in Argentina, 2009-2014

description: <b>Introduction:</b> In Argentina, varicella vaccination was included in the national schedule for mandatory immunizations in 2015. The vaccine has been shown to substantially reduce the morbidity and mortality associated with the virus. The purpose of this study was to evaluate the clinical and economic burden associated with varicella in Argentina prior to vaccine introduction. <b>Methods:</b> This was a multicenter, retrospective chart review study among patients aged 1-12 years with a primary varicella diagnosis in 2009-2014 in Argentina. Healthcare resource utilization (HCRU) associated with varicella and its complications, unit costs, and work loss were used to estimate direct and indirect costs. All costs are presented in 2015 United States dollars (USD). <b>Results:</b> 150 children with varicella were included (75 outpatients, 75 inpatients), with a mean age of 3.8 (SD: 2.4) and 2.9 (SD: 2.2) years, respectively. One or more complications were experienced by 28.0% of outpatients and 98.7% of inpatients, the most common being skin and soft tissue infections, pneumonia, sepsis, cerebellitis, and febrile seizure. HCRU estimates included use of over-the-counter (OTC) medications (58.7% outpatients, 94.7% inpatients), prescription medications (26.7% outpatients, 77.3% inpatients), tests/procedures (13.3% outpatients, 70.7% inpatients), and consultation with allied health professionals (1.3% outpatients, 32.0% inpatients). The average duration of hospital stay was 4.9 (95% CI: 4.2, 5.7) days, and the average duration of ICU stay was 4.8 (95% CI: 1.6, 14.1) days. The total combined direct and indirect cost per varicella case was 2947.7 USD (inpatients) and 322.7 USD (outpatients). The overall annual cost of varicella in Argentina for children aged ≤ 14 years in 2015 was estimated at 40,054,378.0 USD. <b>Conclusion:</b> The clinical burden of varicella in Argentina was associated with utilization of significant amounts of healthcare resources, resulting in substantial economic costs. These costs should be reduced with the recent implementation of routine vaccination of children.
DOI: 10.6084/m9.figshare.5812707.v3
title: Economic burden of varicella in children 1–12 years of age in Argentina, 2009–2014

description: <b>Background:</b> In Argentina, varicella vaccination was included in the national schedule for mandatory immunizations in 2015. The vaccine has been shown to substantially reduce the morbidity and mortality associated with the virus. The purpose of this study was to evaluate the clinical and economic burden associated with varicella in Argentina prior to vaccine introduction. <b>Methods:</b> This was a multi-center, retrospective chart review study among patients aged 1–12 years with a primary varicella diagnosis in 2009–2014 in Argentina. Healthcare resource utilization (HCRU) associated with varicella and its complications, unit costs, and work loss were used to estimate direct and indirect costs. All costs are presented in 2015 United States dollars (USD). <b>Results:</b> One hundred and fifty children with varicella were included (75 outpatients, 75 inpatients), with a mean age of 3.8 (SD = 2.4) and 2.9 (SD = 2.2) years, respectively. One or more complications were experienced by 28.0% of outpatients and 98.7% of inpatients, the most common being skin and soft tissue infections, pneumonia, sepsis, cerebellitis, and febrile seizure. HCRU estimates included use of over-the-counter (OTC) medications (58.7% outpatients, 94.7% inpatients), prescription medications (26.7% outpatients, 77.3% inpatients), tests/procedures (13.3% outpatients, 70.7% inpatients), and consultation with allied health professionals (1.3% outpatients, 32.0% inpatients). The average duration of hospital stay was 4.9 (95% CI = 4.2–5.7) days, and the average duration of ICU stay was 4.8 (95% CI = 1.6–14.1) days. The total combined direct and indirect cost per varicella case was 2947.7 USD (inpatients) and 322.7 USD (outpatients). The overall annual cost of varicella in Argentina for children aged ≤14 years in 2015 was estimated at 40,054,378.0 USD. <b>Conclusion:</b> The clinical burden of varicella in Argentina was associated with utilization of significant amounts of healthcare resources, resulting in substantial economic costs. These costs should be reduced with the recent implementation of routine vaccination of children.
DOI: 10.6084/m9.figshare.5812707.v2
title: Economic burden of varicella in children 1–12 years of age in Argentina, 2009–2014

description: <b>Background:</b> In Argentina, varicella vaccination was included in the national schedule for mandatory immunizations in 2015. The vaccine has been shown to substantially reduce the morbidity and mortality associated with the virus. The purpose of this study was to evaluate the clinical and economic burden associated with varicella in Argentina prior to vaccine introduction. <b>Methods:</b> This was a multi-center, retrospective chart review study among patients aged 1–12 years with a primary varicella diagnosis in 2009–2014 in Argentina. Healthcare resource utilization (HCRU) associated with varicella and its complications, unit costs, and work loss were used to estimate direct and indirect costs. All costs are presented in 2015 United States dollars (USD). <b>Results:</b> One hundred and fifty children with varicella were included (75 outpatients, 75 inpatients), with a mean age of 3.8 (SD = 2.4) and 2.9 (SD = 2.2) years, respectively. One or more complications were experienced by 28.0% of outpatients and 98.7% of inpatients, the most common being skin and soft tissue infections, pneumonia, sepsis, cerebellitis, and febrile seizure. HCRU estimates included use of over-the-counter (OTC) medications (58.7% outpatients, 94.7% inpatients), prescription medications (26.7% outpatients, 77.3% inpatients), tests/procedures (13.3% outpatients, 70.7% inpatients), and consultation with allied health professionals (1.3% outpatients, 32.0% inpatients). The average duration of hospital stay was 4.9 (95% CI = 4.2–5.7) days, and the average duration of ICU stay was 4.8 (95% CI = 1.6–14.1) days. The total combined direct and indirect cost per varicella case was 2947.7 USD (inpatients) and 322.7 USD (outpatients). The overall annual cost of varicella in Argentina for children aged ≤14 years in 2015 was estimated at 40,054,378.0 USD. <b>Conclusion:</b> The clinical burden of varicella in Argentina was associated with utilization of significant amounts of healthcare resources, resulting in substantial economic costs. These costs should be reduced with the recent implementation of routine vaccination of children.
DOI: 10.6084/m9.figshare.5812704
title: Human RNA-seq ratio data before and after hypoxic stress

description: RNA-seq reads were processed using RSEM after the adapter trimming by Trim Galore! (version 0.4.1), which is a wrapper script to automate quality and adapter trimming as well as quality control (https://www.bioinformatics.babraham.ac.uk/projects/trim_galore/). As a reference mapping tool, Bowtie2 (version 2.3.2) was used from RSEM (version1.2.31) following a short tutorial (https://github.com/bli25ucb/RSEM_tutorial).
DOI: 10.6084/m9.figshare.5812701
title: Mouse list of counts after hypoxic stress (up/down/unchanged)

description: The number of experiments in which gene was up/down regulated was counted for all genes in mouse. For up/down regulated gene selection, over 1.5 fold threshold was adopted.
DOI: 10.6084/m9.figshare.5812701.v1
title: Mouse list of counts after hypoxic stress (up/down/unchanged)

description: The number of experiments in which gene was up/down regulated was counted for all genes in mouse. For up/down regulated gene selection, over 1.5 fold threshold was adopted.
DOI: 10.6084/m9.figshare.5812698
title: Mouse microarray log ratio data before and after hypoxic stress

description: The expression values of the genes were calculated from the original CEL files downloaded from NCBI GEO after robust multi-array averaging (RMA) normalization by the affy package (version 1.50.0) in R (version 3.3.3)/BioConductor (version 3.3). Log-transformed (base 2) ratio of hypoxia/normoxia is described in the table.
DOI: 10.6084/m9.figshare.5812698.v1
title: Mouse microarray log ratio data before and after hypoxic stress

description: The expression values of the genes were calculated from the original CEL files downloaded from NCBI GEO after robust multi-array averaging (RMA) normalization by the affy package (version 1.50.0) in R (version 3.3.3)/BioConductor (version 3.3). Log-transformed (base 2) ratio of hypoxia/normoxia is described in the table.
DOI: 10.6084/m9.figshare.5812695
title: Human list of counts after hypoxic stress (up/down/unchanged)

description: The number of experiments in which gene was up/down regulated was counted for all genes in human. For up/down regulated gene selection, over 1.5 fold threshold was adopted. <br>
DOI: 10.6084/m9.figshare.5812695.v1
title: Human list of counts after hypoxic stress (up/down/unchanged)

description: The number of experiments in which gene was up/down regulated was counted for all genes in human. For up/down regulated gene selection, over 1.5 fold threshold was adopted. <br>
DOI: 10.6084/m9.figshare.5812668
title: Human microarray log ratio data before and after hypoxic stress

description: p.p1 {margin: 0.0px 0.0px 0.0px 0.0px; font: 12.0px 'Times New Roman'; color: #000000; -webkit-text-stroke: #000000} span.s1 {font-kerning: none} The expression values of the genes were calculated from the original CEL files downloaded from NCBI GEO after robust multi-array averaging (RMA) normalization [rma] by the affy package (version 1.50.0) in R (version 3.3.3)/BioConductor (version 3.3). Log-transformed (base 2) ratio of hypoxia/normoxia is described in the table.
DOI: 10.6084/m9.figshare.5812668.v1
title: Human microarray log ratio data before and after hypoxic stress

description: p.p1 {margin: 0.0px 0.0px 0.0px 0.0px; font: 12.0px 'Times New Roman'; color: #000000; -webkit-text-stroke: #000000} span.s1 {font-kerning: none} The expression values of the genes were calculated from the original CEL files downloaded from NCBI GEO after robust multi-array averaging (RMA) normalization [rma] by the affy package (version 1.50.0) in R (version 3.3.3)/BioConductor (version 3.3). Log-transformed (base 2) ratio of hypoxia/normoxia is described in the table.
DOI: 10.6084/m9.figshare.5812599
title: Additional file 7 of Chemotherapy weakly contributes to predicted neoantigen expression in ovarian cancer

description: Shared neoantigens. Neoantigens predicted for multiple patients. (CSV 1 kb)