cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.30644265
title: A multi-omics landscape of programmed cell death in acetaminophen-induced acute kidney injury

description: Acetaminophen (APAP) overdose is a known cause of acute kidney injury, yet the underlying molecular mechanisms remain incompletely understood. In this study, we conducted integrated transcriptomic, proteomic, and phosphoproteomic analyses of kidney tissues from mice with early-stage APAP-induced nephrotoxicity and corresponding controls. A total of 884 genes related to 13 distinct forms of programmed cell death (PCD)—including alkaliptosis, apoptosis, autophagy, cuproptosis, disulfidptosis, entotic cell death, ferroptosis, lysosome-dependent cell death, necroptosis, netotic cell death, oxeiptosis, parthanatos, and pyroptosis—were systematically evaluated. Gene set variation analysis was employed to assess the activity of these pathways in APAP-injured kidneys. Moreover, phosphokinase profiling and <i>in vivo</i> inhibition of protein kinase B (AKT) and extracellular signal–regulated kinase were performed to identify potential therapeutic strategies. Pathway enrichment across transcriptomic and proteomic datasets consistently pointed to drug metabolism—particularly cytochrome P450—as a central player. Transcriptomic profiling highlighted six PCD pathways—alkaliptosis, cuproptosis, disulfidptosis, lysosome-dependent cell death, netotic cell death, and pyroptosis—as notably activated in response to APAP exposure. Proteomic analysis further revealed enrichment of eight PCD pathways, including alkaliptosis, apoptosis, entotic cell death, ferroptosis, necroptosis, netotic cell death, oxeiptosis, and pyroptosis. Therapeutically, <i>in vivo</i> inhibition of AKT significantly alleviated renal injury, as demonstrated by improved histopathology, reduced neutrophil gelatinase-associated lipocalin and blood urea nitrogen and suppression of ferroptosis mediators TFRC and ACSL4. Concurrently, it enhanced phosphorylation of p70S6K and FOXO, reflecting improved survival signaling and reduced apoptosis. Together, these findings demonstrate that multiple PCD pathways contribute to early APAP-induced nephrotoxicity and nominate AKT as a central regulatory hub, which merits further exploration in translational nephrotoxicity research.
DOI: 10.6084/m9.figshare.30644265.v1
title: A multi-omics landscape of programmed cell death in acetaminophen-induced acute kidney injury

description: Acetaminophen (APAP) overdose is a known cause of acute kidney injury, yet the underlying molecular mechanisms remain incompletely understood. In this study, we conducted integrated transcriptomic, proteomic, and phosphoproteomic analyses of kidney tissues from mice with early-stage APAP-induced nephrotoxicity and corresponding controls. A total of 884 genes related to 13 distinct forms of programmed cell death (PCD)—including alkaliptosis, apoptosis, autophagy, cuproptosis, disulfidptosis, entotic cell death, ferroptosis, lysosome-dependent cell death, necroptosis, netotic cell death, oxeiptosis, parthanatos, and pyroptosis—were systematically evaluated. Gene set variation analysis was employed to assess the activity of these pathways in APAP-injured kidneys. Moreover, phosphokinase profiling and <i>in vivo</i> inhibition of protein kinase B (AKT) and extracellular signal–regulated kinase were performed to identify potential therapeutic strategies. Pathway enrichment across transcriptomic and proteomic datasets consistently pointed to drug metabolism—particularly cytochrome P450—as a central player. Transcriptomic profiling highlighted six PCD pathways—alkaliptosis, cuproptosis, disulfidptosis, lysosome-dependent cell death, netotic cell death, and pyroptosis—as notably activated in response to APAP exposure. Proteomic analysis further revealed enrichment of eight PCD pathways, including alkaliptosis, apoptosis, entotic cell death, ferroptosis, necroptosis, netotic cell death, oxeiptosis, and pyroptosis. Therapeutically, <i>in vivo</i> inhibition of AKT significantly alleviated renal injury, as demonstrated by improved histopathology, reduced neutrophil gelatinase-associated lipocalin and blood urea nitrogen and suppression of ferroptosis mediators TFRC and ACSL4. Concurrently, it enhanced phosphorylation of p70S6K and FOXO, reflecting improved survival signaling and reduced apoptosis. Together, these findings demonstrate that multiple PCD pathways contribute to early APAP-induced nephrotoxicity and nominate AKT as a central regulatory hub, which merits further exploration in translational nephrotoxicity research.
DOI: 10.6084/m9.figshare.30644268
title: Operationalizing resilience: application of the disaster resilience integrated framework for transformation to enhance community resilience in Fiji

description: Climate change has increased the frequency and severity of weather events worldwide, significantly affecting marginalized communities in Pacific Island Countries, especially in urban informal settlements. These communities face substantial challenges that necessitates a focus on resilience strategies. The prevalence of macro-resilience frameworks and top-down approaches, which often fail to meet the needs of the most vulnerable, has sparked calls for targeted resilience efforts. Limited empirical evidence on how urban informal settlements respond, adapt, or recover from slow-onset human-induced climate events such as coastal, pluvial, and fluvial flooding, further impedes the operationalization of resilience. The study utilizes the Disaster Resilience Integration Framework for Transformation (DRIFT) to explore how macro-resilience frameworks represent the unique challenges faced by marginalized communities across 10 flood-prone urban informal settlements. Focusing on 42 households within Fiji's Greater Suva Urban Area, it documents the resilience capacities that influence flood protection and identifies broader factors that enable or constrain transformative resilience. The findings emphasize the importance of recognizing all resilience capacities as interconnected components within a holistic system, where communities adapt and rely on a blend of responses to navigate systemic constraints. Communities often move both “upward” and “downward” along the resilience spectrum as they confront evolving challenges. Recognizing this interconnectedness is crucial for effectively operationalizing resilience in marginalized communities in the Global South. <b>Trial registration:</b>Australian New Zealand Clinical Trials Registry identifier: ACTRN12618000633280..
DOI: 10.6084/m9.figshare.30644268.v1
title: Operationalizing resilience: application of the disaster resilience integrated framework for transformation to enhance community resilience in Fiji

description: Climate change has increased the frequency and severity of weather events worldwide, significantly affecting marginalized communities in Pacific Island Countries, especially in urban informal settlements. These communities face substantial challenges that necessitates a focus on resilience strategies. The prevalence of macro-resilience frameworks and top-down approaches, which often fail to meet the needs of the most vulnerable, has sparked calls for targeted resilience efforts. Limited empirical evidence on how urban informal settlements respond, adapt, or recover from slow-onset human-induced climate events such as coastal, pluvial, and fluvial flooding, further impedes the operationalization of resilience. The study utilizes the Disaster Resilience Integration Framework for Transformation (DRIFT) to explore how macro-resilience frameworks represent the unique challenges faced by marginalized communities across 10 flood-prone urban informal settlements. Focusing on 42 households within Fiji's Greater Suva Urban Area, it documents the resilience capacities that influence flood protection and identifies broader factors that enable or constrain transformative resilience. The findings emphasize the importance of recognizing all resilience capacities as interconnected components within a holistic system, where communities adapt and rely on a blend of responses to navigate systemic constraints. Communities often move both “upward” and “downward” along the resilience spectrum as they confront evolving challenges. Recognizing this interconnectedness is crucial for effectively operationalizing resilience in marginalized communities in the Global South. <b>Trial registration:</b>Australian New Zealand Clinical Trials Registry identifier: ACTRN12618000633280..
DOI: 10.15468/dl.x98624
title: Occurrence Download

description: A dataset containing 5748 species occurrences available in GBIF matching the query:
{
 "and" : [
 "PublishingOrg is d2583793-e5c1-41ae-83bd-86300d34e2cb",
 "TaxonKey is Animalia"
 ]
}

 The dataset includes 5748 records from 13 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0040489-251025141854904/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.cuwnkn
title: Occurrence Download

description: A dataset containing 13226 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Dodonaea viscosa angustissima",
 "HasCoordinate is true"
 ]
}

 The dataset includes 13226 records from 56 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0040490-251025141854904/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.j94nuw
title: Occurrence Download

description: A dataset containing 2 species occurrences available in GBIF matching the query:
{
 "Geometry" : [
 "POLYGON ((-107.2188 21.14913, -107.0688 21.14913, -107.0688 21.29913, -107.2188 21.29913, -107.2188 21.14913))"
 ]
}

 The dataset includes 2 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0040493-251025141854904/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.ugzk4z
title: Occurrence Download

description: A dataset containing 15 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Hippoglossoides platessoides",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "Year is greater than or equal to 1880",
 "Year is less than or equal to 1889"
 ]
}

 The dataset includes 15 records from 5 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0040494-251025141854904/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.ga46vr
title: Occurrence Download

description: A dataset containing 265 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Drosanthemum hispidum",
 "HasCoordinate is true"
 ]
}

 The dataset includes 265 records from 23 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0040495-251025141854904/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.6084/m9.figshare.30644360
title: The GWAS summaries of 10 muscle metabolites in cattle with a genome-wide significance threshold of P &lt; 5 × 10 <sup>-8</sup>

description: The genotyped with Illumina Bovine 770K Bead chip were imputed to sequence level using Beagle 5.4 based on a multiple-breed reference population consisted of 1,847 individuals from run 8 of the 1000 Bull Genomes Project. A total of 8.2 million variants (MAF &gt; 5% and missing rate &lt; 10%) for 116 individuals were used to perform the genome-wide association analysis. Before running the GWAS, the metabolite abandance with log2 transformation were adjusted for age (month), batch and the first two principal components produced by PLINK 1.9. The associations among variants and metabolites were tested using mixed linear models in GCTA software.
DOI: 10.6084/m9.figshare.30644360.v1
title: The GWAS summaries of 10 muscle metabolites in cattle with a genome-wide significance threshold of P &lt; 5 × 10 <sup>-8</sup>

description: The genotyped with Illumina Bovine 770K Bead chip were imputed to sequence level using Beagle 5.4 based on a multiple-breed reference population consisted of 1,847 individuals from run 8 of the 1000 Bull Genomes Project. A total of 8.2 million variants (MAF &gt; 5% and missing rate &lt; 10%) for 116 individuals were used to perform the genome-wide association analysis. Before running the GWAS, the metabolite abandance with log2 transformation were adjusted for age (month), batch and the first two principal components produced by PLINK 1.9. The associations among variants and metabolites were tested using mixed linear models in GCTA software.
DOI: 10.15468/dl.ahecqx
title: Occurrence Download

description: A dataset containing 9 species occurrences available in GBIF matching the query:
{
 "Geometry" : [
 "POLYGON ((-107.0688 21.14913, -106.9188 21.14913, -106.9188 21.29913, -107.0688 21.29913, -107.0688 21.14913))"
 ]
}

 The dataset includes 9 records from 5 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0040496-251025141854904/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.y6prfj
title: Occurrence Download

description: A dataset containing 8 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Hippoglossoides platessoides",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "Year is greater than or equal to 1890",
 "Year is less than or equal to 1899"
 ]
}

 The dataset includes 8 records from 4 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0040497-251025141854904/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.h6au9v
title: Occurrence Download

description: A dataset containing 5585 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is Colombia",
 "TaxonKey is Falco peregrinus",
 "Year 2000-2025"
 ]
}

 The dataset includes 5585 records from 56 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0040498-251025141854904/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.mtj39q
title: Occurrence Download

description: A dataset containing 2317 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (function (name, pos = -1, envir = as.environment(pos), all.names = FALSE, pattern, sorted = TRUE) \n{\n if (!missing(name)) {\n pos &lt;- tryCatch(name, error = function(e) e)\n if (inherits(pos, \"error\")) {\n name &lt;- substitute(name)\n if (!is.character(name)) \n name &lt;- deparse(name)\n warning(gettextf(\"%s converted to character string\", sQuote(name)), domain = NA)\n pos &lt;- name\n }\n }\n all.names &lt;- .Internal(ls(envir, all.names, sorted))\n if (!missing(pattern)) {\n if ((ll &lt;- length(grep(\"[\", pattern, fixed = TRUE))) && ll != length(grep(\"]\", pattern, fixed = TRUE))) {\n if (pattern == \"[\") {\n pattern &lt;- \"\\\\[\"\n warning(\"replaced regular expression pattern '[' by '\\\\\\\\['\")\n }\n else if (length(grep(\"[^\\\\\\\\]\\\\[&lt;-\", pattern))) {\n pattern &lt;- sub(\"\\\\[&lt;-\", \"\\\\\\\\\\\\[&lt;-\", pattern)\n warning(\"replaced '[&lt;-' by '\\\\\\\\[&lt;-' in regular expression pattern\")\n }\n }\n grep(pattern, all.names, value = TRUE)\n }\n else all.names\n}, Opuntia dillenii, Phyllanthus amarus, Praxelis clematidea)",
 "BasisOfRecord is one of (Specimen, Human Observation, Observation, Living Specimen, Machine Observation, Literature Occurrence)",
 "Country is one of (China, Chinese Taipei)",
 "HasCoordinate is true",
 "HasGeospatialIssue is false"
 ]
}

 The dataset includes 2317 records from 23 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0040500-251025141854904/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.2nhc66
title: Occurrence Download

description: A dataset containing 5 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Dryandra quercifolia",
 "HasCoordinate is true"
 ]
}

 The dataset includes 5 records from 5 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0040499-251025141854904/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.jsbw88
title: Occurrence Download

description: A dataset containing 40 species occurrences available in GBIF matching the query:
{
 "DatasetKey" : [
 "is Amphibians and Reptiles of Santa Cruz Tepetotutla, San Felipe Usila, Oaxaca, México"
 ]
}

 The dataset includes 40 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0040501-251025141854904/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.ca84cg
title: Occurrence Download

description: A dataset containing 2 species occurrences available in GBIF matching the query:
{
 "Geometry" : [
 "POLYGON ((-106.9188 21.14913, -106.7688 21.14913, -106.7688 21.29913, -106.9188 21.29913, -106.9188 21.14913))"
 ]
}

 The dataset includes 2 records from 2 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0040502-251025141854904/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.puzsq5
title: Occurrence Download

description: A dataset containing 66432 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Dodonaea viscosa",
 "HasCoordinate is true"
 ]
}

 The dataset includes 66432 records from 553 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0040459-251025141854904/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.5tdw3q
title: Occurrence Download

description: A dataset containing 12 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Hippoglossoides platessoides",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "Year is greater than or equal to 1900",
 "Year is less than or equal to 1909"
 ]
}

 The dataset includes 12 records from 5 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0040505-251025141854904/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.ugkz59
title: Occurrence Download

description: A dataset listing the 34 species recorded in GBIF matching the query:
{
 "and" : [
 "Geometry POLYGON((177.03788 -38.1785,177.0453 -38.17786,177.05949 -38.17433,177.0691 -38.16984,177.07481 -38.16605,177.08411 -38.15689,177.08953 -38.14762,177.09627 -38.13856,177.10143 -38.12862,177.1042 -38.12008,177.10481 -38.10984,177.104 -38.10399,177.09952 -38.09279,177.09383 -38.0852,177.08355 -38.07672,177.06739 -38.06953,177.06024 -38.06789,177.04762 -38.06682,177.02822 -38.0669,177.01499 -38.06819,177.00114 -38.07244,176.98916 -38.07938,176.97985 -38.08853,176.97501 -38.09648,176.97292 -38.10213,176.97158 -38.11089,176.97164 -38.1333,176.9725 -38.14082,176.97696 -38.15202,176.98265 -38.15962,176.99293 -38.16811,177.00565 -38.1742,177.01993 -38.17749,177.03788 -38.1785))",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 "TaxonKey is one of (Arachnida, Onychophora, Diplopoda, Insecta, Rhytididae, Athoracophoridae, Chilopoda)"
 ]
}

 The dataset's 34 records were derived from 6 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0040491-251025141854904/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.r7gpdx
title: Occurrence Download

description: A dataset containing 4343 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Dyssodia papposa",
 "HasCoordinate is true"
 ]
}

 The dataset includes 4343 records from 135 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0040506-251025141854904/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.sz86nu
title: Occurrence Download

description: A dataset containing 57 species occurrences available in GBIF matching the query:
{
 "Geometry" : [
 "POLYGON ((-106.7688 21.14913, -106.6188 21.14913, -106.6188 21.29913, -106.7688 21.29913, -106.7688 21.14913))"
 ]
}

 The dataset includes 57 records from 7 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0040508-251025141854904/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.v9pc3w
title: Occurrence Download

description: A dataset containing 232 species occurrences available in GBIF matching the query:
{
 "and" : [
 "BasisOfRecord is Human Observation",
 "DatasetKey is iNaturalist Research-grade Observations",
 "GadmGid is USA.6_1",
 "OccurrenceStatus is Present",
 "TaxonKey is Puma concolor",
 "Year 2000-2025"
 ]
}

 The dataset includes 232 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0040507-251025141854904/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.3hyj29
title: Occurrence Download

description: A dataset containing 14 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Hippoglossoides platessoides",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "Year is greater than or equal to 1910",
 "Year is less than or equal to 1919"
 ]
}

 The dataset includes 14 records from 4 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0040509-251025141854904/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.6084/m9.figshare.30068602
title: <b>Data on research entitiled "Non-neglectable </b><b>chemoautotrophic carbon fixation in thermokarst lakes on the Tibetan Plateau"</b>

description: We identified chemoautotrophic carbon fixation in thermokarst lakes by collecting water samples along a ~1,100-km permafrost transect on the Tibetan Plateau.
DOI: 10.6084/m9.figshare.30068602.v2
title: <b>Data on research entitiled "Non-neglectable </b><b>chemoautotrophic carbon fixation in thermokarst lakes on the Tibetan Plateau"</b>

description: We identified chemoautotrophic carbon fixation in thermokarst lakes by collecting water samples along a ~1,100-km permafrost transect on the Tibetan Plateau.
DOI: 10.6084/m9.figshare.30068602.v1
title: <b>Data on research entitiled "Non-neglectable </b><b>chemoautotrophic carbon fixation in thermokarst lakes on the Tibetan Plateau"</b>

description: In this study, we identified chemoautotrophic carbon fixation in thermokarst lakes by collecting water samples along a ~1,100-km permafrost transect on the Tibetan Plateau. Based on biodegradable DOC incubation and <sup>14</sup>C-labeling bicarbonate (NaH<sup>14</sup>CO<sub>3</sub>) assimilation experiment, we examined the DOC dynamics in thermokarst lakes and explored the potential drivers using quantitative PCR (qPCR), high-throughput sequencing, metagenomics and physicochemical analyses.