cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.17632/tdr9sr8ckr
title: Analysis of modified Wumei pills in the treatment of colon cancer based on network pharmacology and bioinformatics

description: In this study, we investigated the potential mechanisms by which modified Wumei pills may contribute to the treatment of colon cancer, utilizing network pharmacology and bioinformatics methodologies. Initially, we identified the effective active ingredients of modified Wumei pills and predicted their corresponding targets using the Traditional Chinese Medicine Systems Pharmacology (TCMSP) database. Subsequently, we employed the GeneCards and Disgenet databases to filter for targets associated with colon cancer. A "drug-active ingredient-target-disease" network was constructed using the Venny platform, resulting in the identification of 112 common targets. Further analysis was conducted using Cytoscape software to create a network map, from which six major target genes were selected based on their Degree values: ADRA2B, CXCR3, CYP19A1, NR1H2, PAPPA, and PGR. A protein-protein interaction (PPI) network was generated using the String database, and the topological parameters were analyzed. Gene Ontology (GO) functional annotation and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses indicated significant enrichment of these target genes in various biological processes, cellular components, and molecular functions, as well as in signaling pathways related to colon cancer. Immunohistochemical analyses demonstrated that these genes were significantly expressed in colon cancer tissues. Receiver Operating Characteristic (ROC) curve analysis revealed that the PGR gene exhibited the strongest prognostic correlation. Additionally, differential gene expression analysis and immunoinfiltration correlation analysis further substantiated the involvement of these genes in colon cancer. Cox regression analysis elucidated the relationship between pathological stage and prognosis, as well as the correlation between CYP19A1 gene expression levels and patient outcomes. Immunochemical bar charts illustrated an increase in the number of specific immune cells in response to high expression levels of the target genes. Single-cell enrichment maps provided insights into the expression patterns of these genes across different cell types. Finally, molecular docking studies indicated that the active ingredients in modified Wumei pills demonstrated a strong binding affinity to the target proteins, particularly highlighting the strongest binding energy between Diop and CXCR3, suggesting potential therapeutic activity. This study provides a scientific foundation for the application of modified Wumei pills in the treatment of colon cancer and offers new avenues for future drug development and therapeutic strategies.
DOI: 10.17632/tdr9sr8ckr.1
title: Analysis of modified Wumei pills in the treatment of colon cancer based on network pharmacology and bioinformatics

description: In this study, we investigated the potential mechanisms by which modified Wumei pills may contribute to the treatment of colon cancer, utilizing network pharmacology and bioinformatics methodologies. Initially, we identified the effective active ingredients of modified Wumei pills and predicted their corresponding targets using the Traditional Chinese Medicine Systems Pharmacology (TCMSP) database. Subsequently, we employed the GeneCards and Disgenet databases to filter for targets associated with colon cancer. A "drug-active ingredient-target-disease" network was constructed using the Venny platform, resulting in the identification of 112 common targets. Further analysis was conducted using Cytoscape software to create a network map, from which six major target genes were selected based on their Degree values: ADRA2B, CXCR3, CYP19A1, NR1H2, PAPPA, and PGR. A protein-protein interaction (PPI) network was generated using the String database, and the topological parameters were analyzed. Gene Ontology (GO) functional annotation and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses indicated significant enrichment of these target genes in various biological processes, cellular components, and molecular functions, as well as in signaling pathways related to colon cancer. Immunohistochemical analyses demonstrated that these genes were significantly expressed in colon cancer tissues. Receiver Operating Characteristic (ROC) curve analysis revealed that the PGR gene exhibited the strongest prognostic correlation. Additionally, differential gene expression analysis and immunoinfiltration correlation analysis further substantiated the involvement of these genes in colon cancer. Cox regression analysis elucidated the relationship between pathological stage and prognosis, as well as the correlation between CYP19A1 gene expression levels and patient outcomes. Immunochemical bar charts illustrated an increase in the number of specific immune cells in response to high expression levels of the target genes. Single-cell enrichment maps provided insights into the expression patterns of these genes across different cell types. Finally, molecular docking studies indicated that the active ingredients in modified Wumei pills demonstrated a strong binding affinity to the target proteins, particularly highlighting the strongest binding energy between Diop and CXCR3, suggesting potential therapeutic activity. This study provides a scientific foundation for the application of modified Wumei pills in the treatment of colon cancer and offers new avenues for future drug development and therapeutic strategies.
DOI: 10.5517/ccdc.csd.cc1pgc2l
title: CCDC 1562929: Experimental Crystal Structure Determination

description: Related Article: Andrea Giunchi, Lorenzo Pandolfi, Raffaele G. Della Valle, Tommaso Salzillo, Elisabetta Venuti, Nicola Demitri, Hans Riegler, Christina Petschacher, Jie Liu, Oliver Werzer|2024|CrystEngComm|26|6573|doi:10.1039/D4CE00605D
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc1pgc3m
title: CCDC 1562930: Experimental Crystal Structure Determination

description: Related Article: Andrea Giunchi, Lorenzo Pandolfi, Raffaele G. Della Valle, Tommaso Salzillo, Elisabetta Venuti, Nicola Demitri, Hans Riegler, Christina Petschacher, Jie Liu, Oliver Werzer|2024|CrystEngComm|26|6573|doi:10.1039/D4CE00605D
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc1pgc4n
title: CCDC 1562931: Experimental Crystal Structure Determination

description: Related Article: Andrea Giunchi, Lorenzo Pandolfi, Raffaele G. Della Valle, Tommaso Salzillo, Elisabetta Venuti, Nicola Demitri, Hans Riegler, Christina Petschacher, Jie Liu, Oliver Werzer|2024|CrystEngComm|26|6573|doi:10.1039/D4CE00605D
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc1pgc5p
title: CCDC 1562932: Experimental Crystal Structure Determination

description: Related Article: Andrea Giunchi, Lorenzo Pandolfi, Raffaele G. Della Valle, Tommaso Salzillo, Elisabetta Venuti, Nicola Demitri, Hans Riegler, Christina Petschacher, Jie Liu, Oliver Werzer|2024|CrystEngComm|26|6573|doi:10.1039/D4CE00605D
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc1pgc6q
title: CCDC 1562933: Experimental Crystal Structure Determination

description: Related Article: Andrea Giunchi, Lorenzo Pandolfi, Raffaele G. Della Valle, Tommaso Salzillo, Elisabetta Venuti, Nicola Demitri, Hans Riegler, Christina Petschacher, Jie Liu, Oliver Werzer|2024|CrystEngComm|26|6573|doi:10.1039/D4CE00605D
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc1pgc7r
title: CCDC 1562934: Experimental Crystal Structure Determination

description: Related Article: Andrea Giunchi, Lorenzo Pandolfi, Raffaele G. Della Valle, Tommaso Salzillo, Elisabetta Venuti, Nicola Demitri, Hans Riegler, Christina Petschacher, Jie Liu, Oliver Werzer|2024|CrystEngComm|26|6573|doi:10.1039/D4CE00605D
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.15468/dl.aj85ay
title: Occurrence Download

description: A dataset containing 183 species occurrences available in GBIF matching the query:
{
 "and" : [
 "OccurrenceStatus is Present",
 "TaxonKey is Aeschynomene fluitans Peter"
 ]
}

 The dataset includes 183 records from 28 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0036365-241126133413365/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.18419/darus-4632
title: Data repository for "Joint Wire Cutting with Non-Maximally Entangled States"

description: This dataset contains the replication code for the publication titled "Joint Wire Cutting with Non-Maximally Entangled States." The provided code represents the version utilized to generate the experimental results documented in the corresponding publication.
The experiments investigate the influence of entangled states in a joint wire cut using different configurations.&lt;br /&gt;&lt;br /&gt;

For comprehensive instructions on using the provided data and code, please refer to the &lt;code&gt;&lt;a href="https://darus.uni-stuttgart.de/file.xhtml?fileId=346494"&gt;README.md&lt;/a&gt;&lt;/code&gt; file. 
To reproduce the plots from the paper, execute the Jupyter notebook &lt;code&gt;plot.ipynb&lt;/code&gt; with the data available in &lt;code&gt;data_exp_1.csv&lt;/code&gt; and &lt;code&gt;data_exp_2.csv&lt;/code&gt;. 
To generate new data, utilize the &lt;code&gt;experiments.ipynb&lt;/code&gt;.
&lt;br /&gt;
DOI: 10.5517/ccdc.csd.cc2kwd40
title: CCDC 2379812: Experimental Crystal Structure Determination

description: Related Article: Yanqi Xu, Anders Reinholdt, Oleg N. Antzutkin, Maria Forsyth, Patrik Johansson, Faiz Ullah Shah|2024|Cryst.Growth Des.|24|8989|doi:10.1021/acs.cgd.4c01030
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2kwd51
title: CCDC 2379813: Experimental Crystal Structure Determination

description: Related Article: Yanqi Xu, Anders Reinholdt, Oleg N. Antzutkin, Maria Forsyth, Patrik Johansson, Faiz Ullah Shah|2024|Cryst.Growth Des.|24|8989|doi:10.1021/acs.cgd.4c01030
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.15468/dl.f5ajrw
title: Occurrence Download

description: A dataset containing 398 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Arctoscopus japonicus (Steindachner, 1881)",
 "Geometry POLYGON((170 20, 170 50, 120 50, 120 20, 170 20))",
 "HasCoordinate is true"
 ]
}

 The dataset includes 398 records from 15 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0036366-241126133413365/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.hzkj2h
title: Occurrence Download

description: A dataset containing 5009 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Geometry POLYGON((118.01 27.03,123.17 27.03,123.17 31.18,118.01 31.18,118.01 27.03))",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 "TaxonKey is Motacilla alba Linnaeus, 1758",
 "Year 2000-2020"
 ]
}

 The dataset includes 5009 records from 5 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0036367-241126133413365/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.17632/5cyvzt2sg4.1
title: Ruixuan Liu study of ID2 promotes axon regeneration by re-establishing redox balance

description: Data
DOI: 10.15468/dl.nhfcne
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Trichodon japonicus Steindachner, 1881",
 "Geometry POLYGON((170 20, 170 50, 120 50, 120 20, 170 20))",
 "HasCoordinate is true"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0036370-241126133413365/datasets/export for details.
DOI: 10.15468/dl.hktfra
title: Occurrence Download

description: A dataset containing 4517 species occurrences available in GBIF matching the query:
{
 "and" : [
 "BasisOfRecord is Human Observation",
 "Geometry POLYGON((-8.55101 35.42811,-2.68131 35.42811,-2.68131 40.04819,-8.55101 40.04819,-8.55101 35.42811))",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 "TaxonKey is Lutra lutra (Linnaeus, 1758)",
 "Year 1980-2024"
 ]
}

 The dataset includes 4517 records from 9 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0036368-241126133413365/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.b62qd7
title: Occurrence Download

description: A dataset containing 1098 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Thelasis Blume"
 ]
}

 The dataset includes 1098 records from 52 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0036371-241126133413365/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.5281/zenodo.12799548
title: Supplementary Tables : U-Pb direct dating on calcite paleosol nodules: first absolute age constraints on the Miocene continental succession of the Paris Basin

description: Supplementary data tables from the manuscript "U-Pb direct dating on calcite paleosol nodules: first absolute age constraints on the Miocene continental succession of the Paris Basin" submitted to Geochronology.

For Supplementary Table 1, the processed data of chemical and isotopic composition is presented along with criteria used to define the ROI, pooling channel, information on map size and relevant pictures of map and ROI selection. Geochronology results are presented in the three system mentioned in the method part of the manuscript. The first thumbnail is the results of QC material DBT, while the second thumbnail is the sample.

For Supplementary Table 2-6, the processed data of chemical and isotopic composition is presented along with information on the number of spots and relevant pictures of ablation localisation on the mounted sample. The first thumbnail is the results of QC material WC-1, while the second thumbnail is the sample.
DOI: 10.5281/zenodo.12799549
title: Supplementary Tables : U-Pb direct dating on calcite paleosol nodules: first absolute age constraints on the Miocene continental succession of the Paris Basin

description: Supplementary data tables from the manuscript "U-Pb direct dating on calcite paleosol nodules: first absolute age constraints on the Miocene continental succession of the Paris Basin" submitted to Geochronology.

For Supplementary Table 1, the processed data of chemical and isotopic composition is presented along with criteria used to define the ROI, pooling channel, information on map size and relevant pictures of map and ROI selection. Geochronology results are presented in the three system mentioned in the method part of the manuscript. The first thumbnail is the results of QC material DBT, while the second thumbnail is the sample.

For Supplementary Table 2-6, the processed data of chemical and isotopic composition is presented along with information on the number of spots and relevant pictures of ablation localisation on the mounted sample. The first thumbnail is the results of QC material WC-1, while the second thumbnail is the sample.
DOI: 10.5281/zenodo.14500416
title: Supplementary Tables : U-Pb direct dating on calcite paleosol nodules: first absolute age constraints on the Miocene continental succession of the Paris Basin

description: Supplementary data tables from the manuscript "U-Pb direct dating on calcite paleosol nodules: first absolute age constraints on the Miocene continental succession of the Paris Basin" submitted to Geochronology.

For Supplementary Table 1, the processed data of chemical and isotopic composition is presented along with criteria used to define the ROI, pooling channel, information on map size and relevant pictures of map and ROI selection. Geochronology results are presented in the three system mentioned in the method part of the manuscript. The first thumbnail is the results of QC material DBT, while the second thumbnail is the sample.

For Supplementary Table 2-6, the processed data of chemical and isotopic composition is presented along with information on the number of spots and relevant pictures of ablation localisation on the mounted sample. The first thumbnail is the results of QC material WC-1, while the second thumbnail is the sample.
DOI: 10.15468/dl.en4dh9
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Alopecias superciliosus Lowe, 1841",
 "Geometry POLYGON((170 20, 170 50, 120 50, 120 20, 170 20))",
 "HasCoordinate is true"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0036373-241126133413365/datasets/export for details.
DOI: 10.15468/dl.c99jpe
title: Occurrence Download

description: A dataset containing 8814 species occurrences available in GBIF matching the query:
{
 "Geometry" : [
 "POLYGON((2.19535 41.37828,2.18279 41.3822,2.17513 41.37388,2.16306 41.35431,2.14871 41.3486,2.13338 41.323,2.12718 41.30718,2.14349 41.29446,2.15148 41.29348,2.16861 41.30881,2.17529 41.31615,2.17236 41.3274,2.17627 41.3504,2.18182 41.35725,2.18622 41.35545,2.19421 41.37062,2.19535 41.37828))"
 ]
}

 The dataset includes 8814 records from 50 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0036372-241126133413365/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.17632/pjhjyxkp4f.1
title: Apology Responses of Javanese and Sundanese_DATA

description: This study examines the differences in how Javanese and Sundanese speakers respond to apologies in various situations, taking into account sociocultural, pragmatic, and gender differences. The results indicate that both groups employ a range of politeness strategies when responding to apologies. The majority of Javanese speakers tend to acknowledge the apology in their responses, while Sundanese speakers often accept the apology using strong hearer-oriented strategies. The responses generally demonstrate indirectness and efforts to mitigate potential threats to the interlocutor's face. However, a notable finding is that there was no significant gender gap in the use of AR strategy, whether within or across different languages, challenging the assumption that females are more accepting and polite than males.
DOI: 10.15468/dl.eebj9v
title: Occurrence Download

description: A dataset containing 134 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Sebastes owstoni (Jordan & Thompson, 1914)",
 "Geometry POLYGON((170 20, 170 50, 120 50, 120 20, 170 20))",
 "HasCoordinate is true"
 ]
}

 The dataset includes 134 records from 10 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0036374-241126133413365/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.17632/6n98cgx9j7.1
title: Appendix for article entitled "Xenolith Zircons Record the Long Geological History of India-Asia Convergence: Results From U-Pb Depth Profiling"

description: This is the online dataset for appendix of an article entitled "Xenolith Zircons Record the Long Geological History of India-Asia Convergence: Results From U-Pb Depth Profiling". Please find Text S1, Fig S1-S3 in Supporing Information file and Table S1-S7 in Supplementary Table file. Please contact the corrsponding author if you have any question.
DOI: 10.6084/m9.figshare.28028762
title: La abertura /e/ &gt; /a/ condicionada por /r/ y /l/ en judeoespañol. Dataset

description: We analyze the opening of unstressed and stressed /e/ in /a/ conditioned by /r/ and /l/ in Judeo-Spanish <i>(parsona, ṿualta).</i> To do this, we previously delimited the casuistry in order to rule out apparent examples of opening. It is possible, then, to specify the contexts that cause the opening, as well as the geography of the phenomenon. We also delve into the use of the opening, since it varies with the conservative solution<i> </i>(<i>puerta</i> ~ <i>puarta</i>), and we conclude with an overview of the phenomenon according to the phonological context and the geographical area.
DOI: 10.6084/m9.figshare.28028762.v3
title: La abertura /e/ &gt; /a/ condicionada por /r/ y /l/ en judeoespañol. Dataset

description: We analyze the opening of unstressed and stressed /e/ in /a/ conditioned by /r/ and /l/ in Judeo-Spanish <i>(parsona, ṿualta).</i> To do this, we previously delimited the casuistry in order to rule out apparent examples of opening. It is possible, then, to specify the contexts that cause the opening, as well as the geography of the phenomenon. We also delve into the use of the opening, since it varies with the conservative solution<i> </i>(<i>puerta</i> ~ <i>puarta</i>), and we conclude with an overview of the phenomenon according to the phonological context and the geographical area.