cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.31396824
title: Supplementary Material for: ARG1 inhibition after Neonatal Hypoxic-Ischemic Brain Injury

description: Introduction: Neonatal hypoxic-ischemic (HI) brain injury is a major cause of mortality and long-term neurological disability, yet effective neuroprotective strategies remain limited. Microglia are central mediators of injury and repair, with arginase-1 (ARG1) marking anti-inflammatory, reparative states. However, the functional roles of ARG1⁺ microglia in tissue remodeling after HI are poorly understood. 

Methods: Neonatal mice (P10) underwent HI using the Vannucci procedure. ARG1 activity was inhibited pharmacologically using N-omega-hydroxy-nor-L-arginine (Nor-NOHA). ARG1 expression, microglial morphology, efferocytosis, tissue scar, and injury volume were assessed via immunohistochemistry, Western blotting, and arginase activity assays at 1 and 5 days post-injury. 

Results: ARG1⁺ microglia rapidly engaged apoptotic neurons, exhibiting phagocytic activity confirmed by CD68 expression. Nor-NOHA treatment reduced ARG1 enzymatic activity, impaired microglial process extension, attenuated efferocytosis, and increased injury volume. ARG1⁺ microglia persisted in the glial scar and co-localized with collagen I alpha 1 (Col1a1), suggesting a role in extracellular matrix (ECM) deposition. Inhibition of ARG1 decreased Col1a1 expression, highlighting its contribution to tissue remodeling. 
 
Conclusions: ARG1⁺ microglia are pivotal in neonatal HI, mediating early efferocytosis and later ECM remodeling, thereby limiting injury and shaping scar architecture. Pharmacological blockade of ARG1 exacerbates injury, underscoring its reparative function. These findings establish ARG1 as a critical regulator of microglial-mediated neuroprotection and tissue repair, providing a potential therapeutic target for neonatal HI brain injury.
DOI: 10.6084/m9.figshare.31396824.v1
title: Supplementary Material for: ARG1 inhibition after Neonatal Hypoxic-Ischemic Brain Injury

description: Introduction: Neonatal hypoxic-ischemic (HI) brain injury is a major cause of mortality and long-term neurological disability, yet effective neuroprotective strategies remain limited. Microglia are central mediators of injury and repair, with arginase-1 (ARG1) marking anti-inflammatory, reparative states. However, the functional roles of ARG1⁺ microglia in tissue remodeling after HI are poorly understood. 

Methods: Neonatal mice (P10) underwent HI using the Vannucci procedure. ARG1 activity was inhibited pharmacologically using N-omega-hydroxy-nor-L-arginine (Nor-NOHA). ARG1 expression, microglial morphology, efferocytosis, tissue scar, and injury volume were assessed via immunohistochemistry, Western blotting, and arginase activity assays at 1 and 5 days post-injury. 

Results: ARG1⁺ microglia rapidly engaged apoptotic neurons, exhibiting phagocytic activity confirmed by CD68 expression. Nor-NOHA treatment reduced ARG1 enzymatic activity, impaired microglial process extension, attenuated efferocytosis, and increased injury volume. ARG1⁺ microglia persisted in the glial scar and co-localized with collagen I alpha 1 (Col1a1), suggesting a role in extracellular matrix (ECM) deposition. Inhibition of ARG1 decreased Col1a1 expression, highlighting its contribution to tissue remodeling. 
 
Conclusions: ARG1⁺ microglia are pivotal in neonatal HI, mediating early efferocytosis and later ECM remodeling, thereby limiting injury and shaping scar architecture. Pharmacological blockade of ARG1 exacerbates injury, underscoring its reparative function. These findings establish ARG1 as a critical regulator of microglial-mediated neuroprotection and tissue repair, providing a potential therapeutic target for neonatal HI brain injury.
DOI: 10.5281/zenodo.18752587
title: Agricultural Drought Hazard Dataset – Gridded and District-Level Crop Yield Loss Projections (EURO-CORDEX EUR-11 Ensemble, RCP8.5, 2046–2050) for Aydın Province, Türkiye (CliResDairy)

description: This dataset contains the agricultural drought hazard outputs developed for Aydın Province, Türkiye, under the CLIMAAX project.

This dataset provides gridded and district-level agricultural drought hazard projections for Aydın Province, Türkiye, under RCP8.5 (2046–2050). It includes crop yield loss (%) per GCM–RCM ensemble member and ensemble median, computed using FAO-56 evapotranspiration and FAO I&D 33 yield-response methodology.

File: yield_loss_gridded.zip



Contains crop yield loss (%) per:

Grid cell (~12 km resolution)

Crop type

Individual GCM–RCM ensemble member


For each crop and model pair, annual mean water stress is converted to percentage yield loss.

The dataset includes:



Yield loss per ensemble member

Ensemble median yield loss


File: yield_loss_district_level.zip

Aggregated yield loss (%) at district (ilçe) level, including:



Individual GCM–RCM member results

Ensemble median yield loss


Aggregation is performed using spatial masking of gridded outputs onto district boundaries.

File: crop_table.xlsx



Contains crop-specific physiological and agronomic parameters required for ET₀ and water balance


File: crops_aydin.xlsx

Contains district-level crop production statistics for fodder crops relevant to the dairy sector.

File: cordex_members.csv

Lists GCM–RCM combinations used in the hazard computation.

File: crop_prices_fao.xlsx

Contains international FAO commodity price data (USD/ton).

File: Plots.zip

Contains district-level maps per crop, including:



Historical yield (kg/ha)

Projected yield loss (%)

Projected production loss (tons)
DOI: 10.6084/m9.figshare.31396827
title: Supplementary Material for: Global Burden of Encephalitis from 1990 to 2021, Its Attributable Risk Factors, and Projections to 2045

description: Introduction: Encephalitis represents a significant and evolving global health threat. We aimed to estimate the spatiotemporal patterns of the encephalitis burden and its attributable risk factors at national, regional, and global levels, and to project future trends to guide targeted prevention and treatment programs.

Methods: This study analyzed incidence, mortality, and disability-adjusted life years (DALYs) utilizing data from the Global Burden of Disease (GBD) Study 2021. Joinpoint regression modeling was employed to identify significant turning points in age-standardized rates (ASRs). A decomposition analysis was conducted to dissect the contributions of aging, population growth, and epidemiological changes to the overall burden. Furthermore, the Bayesian age-period-cohort (BAPC) model was applied to project the global trend of encephalitis from 2021 to 2045.

Results: Although the global burden of encephalitis has generally declined over the past three decades, the reduction in ASRs ceased between 2012 and 2015. Projections indicate that ASRs will stabilize rather than continue to decline from 2021 to 2045. The disease burden remains disproportionately high in regions with a low-medium Socio-demographic Index (SDI). Demographic analysis identifies children and the elderly as high-risk populations, with low birth weight identified as a prominent risk factor for neonatal encephalitis burden.

Conclusions: The decline in encephalitis ASRs reached an inflection point during 2012–2015, potentially driven by epidemiological shifts such as emerging infectious or autoimmune etiologies. The concentration of burden in low-medium SDI regions suggests a link to tropical distributions and healthcare disparities. Targeted interventions, including promoting vaccination, enhancing prenatal care, and creating smoke-free environments, are essential to mitigate the future burden of encephalitis.
DOI: 10.6084/m9.figshare.31396827.v1
title: Supplementary Material for: Global Burden of Encephalitis from 1990 to 2021, Its Attributable Risk Factors, and Projections to 2045

description: Introduction: Encephalitis represents a significant and evolving global health threat. We aimed to estimate the spatiotemporal patterns of the encephalitis burden and its attributable risk factors at national, regional, and global levels, and to project future trends to guide targeted prevention and treatment programs.

Methods: This study analyzed incidence, mortality, and disability-adjusted life years (DALYs) utilizing data from the Global Burden of Disease (GBD) Study 2021. Joinpoint regression modeling was employed to identify significant turning points in age-standardized rates (ASRs). A decomposition analysis was conducted to dissect the contributions of aging, population growth, and epidemiological changes to the overall burden. Furthermore, the Bayesian age-period-cohort (BAPC) model was applied to project the global trend of encephalitis from 2021 to 2045.

Results: Although the global burden of encephalitis has generally declined over the past three decades, the reduction in ASRs ceased between 2012 and 2015. Projections indicate that ASRs will stabilize rather than continue to decline from 2021 to 2045. The disease burden remains disproportionately high in regions with a low-medium Socio-demographic Index (SDI). Demographic analysis identifies children and the elderly as high-risk populations, with low birth weight identified as a prominent risk factor for neonatal encephalitis burden.

Conclusions: The decline in encephalitis ASRs reached an inflection point during 2012–2015, potentially driven by epidemiological shifts such as emerging infectious or autoimmune etiologies. The concentration of burden in low-medium SDI regions suggests a link to tropical distributions and healthcare disparities. Targeted interventions, including promoting vaccination, enhancing prenatal care, and creating smoke-free environments, are essential to mitigate the future burden of encephalitis.
DOI: 10.15468/dl.sx7ata
title: Occurrence Download

description: A dataset containing 8968 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Plumularia",
 "HasCoordinate is true",
 "HasGeospatialIssue is false"
 ]
}

 The dataset includes 8968 records from 189 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0005615-260221153910048/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.86vsjt
title: Occurrence Download

description: A dataset containing 2069 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Plantae, Aves, Insecta)",
 "Geometry MULTIPOLYGON (((9.801473 1.892649, 9.80153 1.908828, 9.791548 1.908828, 9.791492 1.892649, 9.781511 1.892649, 9.781483 1.884559, 9.771501 1.884559, 9.771474 1.87647, 9.761492 1.87647, 9.761465 1.868381, 9.751484 1.868381, 9.751456 1.860291, 9.741475 1.860291, 9.741393 1.836024, 9.731412 1.836024, 9.731358 1.819845, 9.741339 1.819845, 9.741285 1.803667, 9.761247 1.803667, 9.76122 1.795577, 9.781182 1.795577, 9.781208 1.803667, 9.791189 1.803667, 9.791216 1.811756, 9.831139 1.811756, 9.83136 1.87647, 9.821379 1.87647, 9.821407 1.884559, 9.811426 1.884559, 9.811454 1.892649, 9.801473 1.892649)))"
 ]
}

 The dataset includes 2069 records from 22 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0005616-260221153910048/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.4j9q9j
title: Occurrence Download

description: A dataset containing 1 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Toxicocalamus grandis"
 ]
}

 The dataset includes 1 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0005617-260221153910048/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.cev4be
title: Occurrence Download

description: A dataset containing 18 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Goniurosaurus araneus"
 ]
}

 The dataset includes 18 records from 7 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0005618-260221153910048/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.5281/zenodo.18752760
title: MITRAL STENOSIS ETIOLOGY, PATHOGENESIS AND CLINICAL SYMPTOMS

description: This article systematizes the etiology, pathogenesis, and clinical manifestations of mitral stenosis through an analytical review of contemporary literature. Narrative and comparative bibliographic methods were applied. The results distinguish mechanisms typical of rheumatic versus degenerative disease, outline major hemodynamic consequences, and identify early clinical markers. The study strengthens differential diagnostic reasoning and supports clinically oriented stratification.
DOI: 10.5281/zenodo.18752759
title: MITRAL STENOSIS ETIOLOGY, PATHOGENESIS AND CLINICAL SYMPTOMS

description: This article systematizes the etiology, pathogenesis, and clinical manifestations of mitral stenosis through an analytical review of contemporary literature. Narrative and comparative bibliographic methods were applied. The results distinguish mechanisms typical of rheumatic versus degenerative disease, outline major hemodynamic consequences, and identify early clinical markers. The study strengthens differential diagnostic reasoning and supports clinically oriented stratification.
DOI: 10.15468/dl.yschyh
title: Occurrence Download

description: A dataset containing 601 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Croton niveus",
 "Country is Colombia",
 "HasCoordinate is true"
 ]
}

 The dataset includes 601 records from 37 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0005621-260221153910048/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.egq7wd
title: Occurrence Download

description: A dataset containing 68017 species occurrences available in GBIF matching the query:
{
 "and" : [
 "HasGeospatialIssue is false",
 "HasCoordinate is true",
 "OccurrenceStatus is Present",
 {
 "not" : {
 "BasisOfRecord" : [
 "is one of (Fossil, Living Specimen)"
 ]
 }
 },
 "TaxonKey is Bromus hordeaceus",
 "Year is less than or equal to 2000",
 "Year is greater than or equal to 1970",
 {
 "or" : [
 {
 "not" : {
 "EstablishmentMeans" : [
 "is one of (MANAGED, INTRODUCED)"
 ]
 }
 },
 "EstablishmentMeans is null"
 ]
 },
 {
 "or" : [
 "CoordinateUncertaintyInMeters is less than 1000",
 "CoordinateUncertaintyInMeters is null"
 ]
 }
 ]
}

 The dataset includes 68017 records from 352 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0005564-260221153910048/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.svtvys
title: Occurrence Download

description: A dataset containing 61784 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Geometry POLYGON((-141.32669 19.57969,-31.67331 19.57969,-31.67331 63.42031,-141.32669 63.42031,-141.32669 19.57969))",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 "TaxonKey is Pseudacris crucifer"
 ]
}

 The dataset includes 61784 records from 80 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0005566-260221153910048/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.ew87fm
title: Occurrence Download

description: A dataset containing 17 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is Canada",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 "TaxonKey is Isoetes eatonii"
 ]
}

 The dataset includes 17 records from 8 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0005622-260221153910048/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.z3bxtv
title: Occurrence Download

description: A dataset containing 10267 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Gyroidinoides",
 "HasCoordinate is true",
 "HasGeospatialIssue is false"
 ]
}

 The dataset includes 10267 records from 275 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0005623-260221153910048/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.54rytj
title: Occurrence Download

description: A dataset containing 508 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Brachypodium hybridum"
 ]
}

 The dataset includes 508 records from 46 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0005624-260221153910048/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.kd6wwn
title: Occurrence Download

description: A dataset listing the 162790 species recorded in GBIF matching the query:
{
 "and" : [
 "Continent is Asia",
 "Country is India",
 "OccurrenceStatus is Present"
 ]
}

 The dataset's 162790 records were derived from 4414 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0005605-260221153910048/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.25921/sd0x-8n14
title: NOAA/WDS Paleoclimatology - Jamaica Bay, Acklins Island - Sclerosponge Lead and Carbon Isotope Data

description: Lead concentrations have been analyzed on a 223 yr profile through the aragonitic skeleton of the reef-building Caribbean sclerosponge Ceratoporella nicholsoni by using laser-ablation inductively coupled plasmaŋmass spectrometry. A parallel study of the d13C distribution in the skeleton validates the previously established mean annual growth rate of 230 ĩm/yr, at least for long-term important environmental changes. The Pb trend in the specimen displays a general increase from 0.30 ppm ca. A.D. 1760 to 2.15 ppm ca. A.D. 1984; a major threefold increase occurred after 1930. This Pb profile is analogous to results acquired from ice or coral cores and clearly highlights the potential of sclerosponges as a new proxy of environmental changes for time series extending over several centuries.
description: A specimen of Ceratoporella nicholsoni, 14 cm in diameter, was collected in a reef crevice at a depth of 30 m on the fore-reef slope of Jamaica Bay (southern tip of Acklins Island), Bahamas, in August 1985. A diamond saw was used to cut a 5-mm-thick slab perpendicular to the surface of the specimen. A maximum age of 390 yr was assigned to the specimen (9 cm high along growth axis), based on a mean annual growth rate of 230 ± 45 mm/yr, obtained from in situ labeling of 10 specimens with calcein over a 10 yr interval in Jamaica (Willenz and Hartman, 1999). Carbon isotope analysis was performed on a Finnigan Mat Delta E stable isotope-ratio mass spectrometer. The Pb data were acquired by using laser-ablation inductively coupled plasma mass spectrometry (LA-ICP-MS), a microanalysis technique allowing high spatial and thus temporal resolution. The LA-ICP-MS analyses were made with a frequency-quadrupled ultraviolet-wavelength (266 nm) Nd-YAG (neodymium-doped yttrium aluminum garnet) Fisons-VG microprobe and a Fisons-VG PlasmaQuad II+ mass spectrometer.
DOI: 10.25921/stg3-jr07
title: NOAA/WDS Paleoclimatology - Weber - ERM - FASY - ITRDB CHE580

description: Tree ring data from the International Tree Ring Data Bank and World Data Center for Paleoclimatology archives.  Most data sets include raw treering measurements (most are annual ring width, with some collections of earlywood or latewood width or wood density), plus chronologies (standardized growth indices for a site compiled from multiple treering samples). Reconstructions of climate variables are included with some of these data sets.  Each data type is stored in a separate data file; the data type is coded into the file name. For details please see: http://www.ncdc.noaa.gov/paleo/treeinfo.htmll
DOI: 10.15468/dl.6g9qxg
title: Occurrence Download

description: A dataset containing 18512 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Viola stagnina"
 ]
}

 The dataset includes 18512 records from 252 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0024530-251009101135966/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.25921/s75k-mg02
title: NOAA/WDS Paleoclimatology - Esper - Are ESA3 - PCAB - ITRDB SWE350

description: Tree ring data from the International Tree Ring Data Bank and World Data Center for Paleoclimatology archives.  Most data sets include raw treering measurements (most are annual ring width, with some collections of earlywood or latewood width or wood density), plus chronologies (standardized growth indices for a site compiled from multiple treering samples). Reconstructions of climate variables are included with some of these data sets.  Each data type is stored in a separate data file; the data type is coded into the file name. For details please see: http://www.ncdc.noaa.gov/paleo/treeinfo.htmll
DOI: 10.25921/s9d4-5y55
title: NOAA/WDS Paleoclimatology - Akcakale Cave Geochemical Data from 440 to -55 Cal Yr BP

description: A verified instrumental calibration of annually resolved δ18O for a stalagmite from Gümüşhane in northeast Turkey is presented and cross-validated using a ‘leave-one-out’ technique. The amount of late autumn to winter precipitation is negatively correlated with stalagmite δ18O between AD 1938 and 2004. The observed relationship is extrapolated back to ~ AD 1500 leading to the first long winter precipitation reconstruction for this region. Modern day October to January precipitation is linked to pressure fields in Western Russia. Anomalously lower reconstructed rainfall is recorded in AD 1540–1560 at which time higher pressure over the Caspian Sea region is inferred.
description: Data contributed as part of SISAL v3 Global Speleothem Isotope and Trace Element Database (https://doi.org/10.25921/jajq-qg60). Notes from the SISAL database: Vegetation and land use: Tree growth in what appears to be a dried up river bed and evidence of farming in close proximity (ploughed field). \\ 2p (SISAL entity_id = 559): Original publication suggests a laminae age uncertainty of +/-2-3%.