cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.17632/v6nggbdt75
title: The Role of the CTBP2 Mediated Glycolytic Pathway in Nasopharyngeal Carcinoma Metastasis

description: Nasopharyngeal carcinoma (NPC), a highly aggressive and metastatic head and neck malignancy, exhibits invasion and metastasis closely linked to aerobic glycolysis. This study systematically analyzed the effect of CTBP2-mediated glycolytic signaling on NPC progression to elucidate the role of metabolic regulation in tumor development.
Immunohistochemistry was used to assess expression and localization of CTBP2 and ZEB1 in NPC tissues, metastatic lesions, and adjacent tissues. Both proteins were highly expressed in NPC and metastatic tissues, indicating their involvement in tumorigenesis and metastasis. Statistical analysis revealed significant differences between metastatic and primary NPC tissues, with CTBP2 expression correlating with T, N, and M stages. These findings suggest that CTBP2 contributes to NPC invasion and metastasis.
CTBP2 knockdown vectors were constructed, and HNE-1 cells were divided into control, si-NC, and si-CTBP2 groups. Cell viability was evaluated by CCK-8, invasion by Transwell, and metabolic alterations by extracellular acidification rate, lactate production, and glucose uptake. Compared with si-NC, si-CTBP2 significantly reduced proliferation and invasion. Glycolysis, glycolytic capacity, and reserve were decreased, while non-glycolytic acidification remained unchanged. 2-DG6P and lactate levels were reduced, indicating impaired glucose uptake and lactate generation. Collectively, CTBP2 knockdown suppressed glycolysis at the transcriptional level, reducing HNE-1 proliferation and invasion, suggesting its role in regulating glycolysis-related genes in NPC. qPCR confirmed that CTBP2 silencing also reduced ZEB1 mRNA, indicating transcriptional suppression of ZEB1.
To further validate this axis, HNE-1 cells were treated with si-NC, si-CTBP2, si-CTBP2+OE-NC, and si-CTBP2+OE-ZEB1. CCK-8 and wound-healing assays showed that si-CTBP2 significantly reduced proliferation and migration, while ZEB1 overexpression reversed these effects, supporting its role in promoting NPC progression.
A ZEB1 overexpression plasmid (ZEB1-pcDNA3.1(+)) was transfected into HNE-1 cells. Dual-luciferase reporter constructs (HK2-promoter-pmirGLO) were co-transfected with ZEB1-pcDNA3.1(+) into 293T cells. Overexpression significantly increased ZEB1 mRNA and enhanced HK2 promoter activity, confirming direct binding and transcriptional activation of HK2 by ZEB1, thereby facilitating glycolysis.
In vivo, HNE-1 xenograft models were established in nude mice with CTBP2 knockdown or control. Tumor growth was monitored, and molecular analyses performed. CTBP2 silencing markedly inhibited tumor growth, reduced CTBP2 and ZEB1 mRNA, increased E-cadherin protein, and decreased Vimentin, GLUT1, HK2, and ZEB1 expression.
In conclusion, CTBP2 regulates glycolysis and EMT in NPC through ZEB1 transcriptional control. Its silencing suppresses proliferation, invasion, and metastasis, highlighting CTBP2 as a potential therapeutic target.
DOI: 10.17632/v6nggbdt75.1
title: The Role of the CTBP2 Mediated Glycolytic Pathway in Nasopharyngeal Carcinoma Metastasis

description: Nasopharyngeal carcinoma (NPC), a highly aggressive and metastatic head and neck malignancy, exhibits invasion and metastasis closely linked to aerobic glycolysis. This study systematically analyzed the effect of CTBP2-mediated glycolytic signaling on NPC progression to elucidate the role of metabolic regulation in tumor development.
Immunohistochemistry was used to assess expression and localization of CTBP2 and ZEB1 in NPC tissues, metastatic lesions, and adjacent tissues. Both proteins were highly expressed in NPC and metastatic tissues, indicating their involvement in tumorigenesis and metastasis. Statistical analysis revealed significant differences between metastatic and primary NPC tissues, with CTBP2 expression correlating with T, N, and M stages. These findings suggest that CTBP2 contributes to NPC invasion and metastasis.
CTBP2 knockdown vectors were constructed, and HNE-1 cells were divided into control, si-NC, and si-CTBP2 groups. Cell viability was evaluated by CCK-8, invasion by Transwell, and metabolic alterations by extracellular acidification rate, lactate production, and glucose uptake. Compared with si-NC, si-CTBP2 significantly reduced proliferation and invasion. Glycolysis, glycolytic capacity, and reserve were decreased, while non-glycolytic acidification remained unchanged. 2-DG6P and lactate levels were reduced, indicating impaired glucose uptake and lactate generation. Collectively, CTBP2 knockdown suppressed glycolysis at the transcriptional level, reducing HNE-1 proliferation and invasion, suggesting its role in regulating glycolysis-related genes in NPC. qPCR confirmed that CTBP2 silencing also reduced ZEB1 mRNA, indicating transcriptional suppression of ZEB1.
To further validate this axis, HNE-1 cells were treated with si-NC, si-CTBP2, si-CTBP2+OE-NC, and si-CTBP2+OE-ZEB1. CCK-8 and wound-healing assays showed that si-CTBP2 significantly reduced proliferation and migration, while ZEB1 overexpression reversed these effects, supporting its role in promoting NPC progression.
A ZEB1 overexpression plasmid (ZEB1-pcDNA3.1(+)) was transfected into HNE-1 cells. Dual-luciferase reporter constructs (HK2-promoter-pmirGLO) were co-transfected with ZEB1-pcDNA3.1(+) into 293T cells. Overexpression significantly increased ZEB1 mRNA and enhanced HK2 promoter activity, confirming direct binding and transcriptional activation of HK2 by ZEB1, thereby facilitating glycolysis.
In vivo, HNE-1 xenograft models were established in nude mice with CTBP2 knockdown or control. Tumor growth was monitored, and molecular analyses performed. CTBP2 silencing markedly inhibited tumor growth, reduced CTBP2 and ZEB1 mRNA, increased E-cadherin protein, and decreased Vimentin, GLUT1, HK2, and ZEB1 expression.
In conclusion, CTBP2 regulates glycolysis and EMT in NPC through ZEB1 transcriptional control. Its silencing suppresses proliferation, invasion, and metastasis, highlighting CTBP2 as a potential therapeutic target.
DOI: 10.17632/rrfhcrmmcb
title: administrative limits DOI:10.20944/preprints202508.0467.v1

description: Administrative (province and comarcas) for DOI:10.20944/preprints202508.0467.v1
DOI: 10.17632/rrfhcrmmcb.1
title: administrative limits DOI:10.20944/preprints202508.0467.v1

description: Administrative (province and comarcas) for DOI:10.20944/preprints202508.0467.v1
DOI: 10.15468/dl.whbb6r
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Cichorium endivia",
 "Country is Yemen",
 "HasCoordinate is true"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0016290-250827131500795/datasets/export for details.
DOI: 10.15468/dl.2j3hh8
title: Occurrence Download

description: A dataset containing 7243 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Leptothorax acervorum"
 ]
}

 The dataset includes 7243 records from 185 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0016292-250827131500795/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.5281/zenodo.17009556
title: Data for "Nonequilibrium plasmon liquid in a Josephson junction chain"
DOI: 10.5281/zenodo.17009557
title: Data for "Nonequilibrium plasmon liquid in a Josephson junction chain"
DOI: 10.5281/zenodo.17022875
title: scRNA-seq of the tumor microenvironment in a subcutaneous melanoma mouse model after nilotinib-copper treatment

description: Modeling method: 1*10^5 B16 cells were injected subcutaneously on the right side of the abdomen. Nilotinib-copper treatment: Nilotinib was administered orally and copper was administered intraperitoneally once daily for 2 weeks. Control group: DMSO was given orally and NaCl was administered intraperitoneally once daily for 2 weeks.
DOI: 10.5281/zenodo.17022876
title: scRNA-seq of the tumor microenvironment in a subcutaneous melanoma mouse model after nilotinib-copper treatment

description: Modeling method: 1*10^5 B16 cells were injected subcutaneously on the right side of the abdomen. Nilotinib-copper treatment: Nilotinib was administered orally and copper was administered intraperitoneally once daily for 2 weeks. Control group: DMSO was given orally and NaCl was administered intraperitoneally once daily for 2 weeks.
DOI: 10.34894/ubdhlz
title: Sitting Behaviors from Healthy Population Dataset
title: Raw data of sitting postures from pressure mats and bioradar

description: Raw data of sitting postures from 38 participants are collected from pressure mat with grid size of 16x16 and from bioradar. Raw data is collected for 5 working days in office environment. Pressure mat is placed on the top of the office chair and bioradar is placed on the side of the table. Ground truth labelling of sitting posture is manually annotated from video recording (Kinect v1.8). Kinects are placed on the side of the table and under the table. The ground truth labelling included both upper and lower body parts. The description of posture labelling can be found further in the attached document. At the moment, only labelling from pressure mat data is openly available. The labelling from Bioradar data will follow.

The sitting posture labelling and the raw data from pressure mat and bioradar is structured per participant. These data is stored in .csv format. Preprocess pressure mat folder consists of merged pressure mat data and the labelling by their timestamp. Preprocess labelling folder consists of pressure mat labelling that have been integrated into one file for single day.
DOI: 10.6084/m9.figshare.30024868
title: Dataset for "Mental representation derived from path descriptions: Can natural-based landmarks make the difference?"

description: A total of 160 young adults (96 women, aged 19–35) were assessed for individual differences preferences and listened to three route descriptions featuring different landmark types. Emotional state was measured before and after each description, along with spatial recall (map drawing). Landmark recall, pleasantness, and vividness were also evaluated
DOI: 10.6084/m9.figshare.30024868.v1
title: Dataset for "Mental representation derived from path descriptions: Can natural-based landmarks make the difference?"

description: A total of 160 young adults (96 women, aged 19–35) were assessed for individual differences preferences and listened to three route descriptions featuring different landmark types. Emotional state was measured before and after each description, along with spatial recall (map drawing). Landmark recall, pleasantness, and vividness were also evaluated
DOI: 10.5281/zenodo.14826251
title: Glyco-RESI Data

description: Localization Microscopy Datasets from this publication: https://dx.doi.org/10.1038/s41565-025-01966-5. Archive contains all relevant .hdf5 datasets.
DOI: 10.5281/zenodo.14826252
title: Glyco-RESI Data

description: Localization Microscopy Datasets from this publication: https://dx.doi.org/10.1038/s41565-025-01966-5. Archive contains all relevant .hdf5 datasets.
DOI: 10.11588/duerer.online.68b5c0c405de2
title: Anbetung der Könige, https://d-nb.info/gnd/120103972X
DOI: 10.5281/zenodo.15552356
title: CD20 and Therapeutic Antibody RESI datasets

description: Localization Microscopy Datasets and custom analysis script from this publication: https://dx.doi.org/10.1038/s41467-025-61893-w
DOI: 10.5281/zenodo.15552355
title: CD20 and Therapeutic Antibody RESI datasets

description: Localization Microscopy Datasets and custom analysis script from this publication: https://dx.doi.org/10.1038/s41467-025-61893-w
DOI: 10.5517/ccdc.csd.cc2bpn7y
title: CCDC 2165760: Experimental Crystal Structure Determination

description: Related Article: Peter G. Jones, Matthias Freytag, Nico Ehrlich, Marc D. Walter|2022|CSD Communication|||
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2bpnk8
title: CCDC 2165770: Experimental Crystal Structure Determination

description: Related Article: Peter G. Jones, Matthias Freytag, Nico Ehrlich, Marc D. Walter|2022|CSD Communication|||
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2bpnl9
title: CCDC 2165771: Experimental Crystal Structure Determination

description: Related Article: Peter G. Jones, Matthias Freytag, Nico Ehrlich, Marc D. Walter|2022|CSD Communication|||
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2bpx10
title: CCDC 2166002: Experimental Crystal Structure Determination

description: Related Article: Martin Nieger, Andrea Hokky, Dietrich Gudat|2022|CSD Communication|||
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2bqjj4
title: CCDC 2166606: Experimental Crystal Structure Determination

description: Related Article: Hongjie Gao, Jia-Yi Chen, Zhiqiang Peng, Lei Feng, Chen-Ho Tung, Wenguang Wang|2022|J.Org.Chem.|87|10848|doi:10.1021/acs.joc.2c01122
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2bqjk5
title: CCDC 2166607: Experimental Crystal Structure Determination

description: Related Article: Hongjie Gao, Jia-Yi Chen, Zhiqiang Peng, Lei Feng, Chen-Ho Tung, Wenguang Wang|2022|J.Org.Chem.|87|10848|doi:10.1021/acs.joc.2c01122
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2bqjl6
title: CCDC 2166608: Experimental Crystal Structure Determination

description: Related Article: Hongjie Gao, Jia-Yi Chen, Zhiqiang Peng, Lei Feng, Chen-Ho Tung, Wenguang Wang|2022|J.Org.Chem.|87|10848|doi:10.1021/acs.joc.2c01122
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2bqxkk
title: CCDC 2166979: Experimental Crystal Structure Determination

description: Related Article: Conor T. Kelly, Michael Griffin, Kane Esien, Solveig Felton, Helge Müller-Bunz, Grace G. Morgan|2022|Cryst.Growth Des.|22|6429|doi:10.1021/acs.cgd.2c00468
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2bqxll
title: CCDC 2166980: Experimental Crystal Structure Determination

description: Related Article: Conor T. Kelly, Michael Griffin, Kane Esien, Solveig Felton, Helge Müller-Bunz, Grace G. Morgan|2022|Cryst.Growth Des.|22|6429|doi:10.1021/acs.cgd.2c00468
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2bqxmm
title: CCDC 2166981: Experimental Crystal Structure Determination

description: Related Article: Conor T. Kelly, Michael Griffin, Kane Esien, Solveig Felton, Helge Müller-Bunz, Grace G. Morgan|2022|Cryst.Growth Des.|22|6429|doi:10.1021/acs.cgd.2c00468
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2bqxnn
title: CCDC 2166982: Experimental Crystal Structure Determination

description: Related Article: Conor T. Kelly, Michael Griffin, Kane Esien, Solveig Felton, Helge Müller-Bunz, Grace G. Morgan|2022|Cryst.Growth Des.|22|6429|doi:10.1021/acs.cgd.2c00468
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2bqxpp
title: CCDC 2166983: Experimental Crystal Structure Determination

description: Related Article: Conor T. Kelly, Michael Griffin, Kane Esien, Solveig Felton, Helge Müller-Bunz, Grace G. Morgan|2022|Cryst.Growth Des.|22|6429|doi:10.1021/acs.cgd.2c00468
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2bqxqq
title: CCDC 2166984: Experimental Crystal Structure Determination

description: Related Article: Conor T. Kelly, Michael Griffin, Kane Esien, Solveig Felton, Helge Müller-Bunz, Grace G. Morgan|2022|Cryst.Growth Des.|22|6429|doi:10.1021/acs.cgd.2c00468
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2bqxrr
title: CCDC 2166985: Experimental Crystal Structure Determination

description: Related Article: Conor T. Kelly, Michael Griffin, Kane Esien, Solveig Felton, Helge Müller-Bunz, Grace G. Morgan|2022|Cryst.Growth Des.|22|6429|doi:10.1021/acs.cgd.2c00468
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2bqxss
title: CCDC 2166986: Experimental Crystal Structure Determination

description: Related Article: Conor T. Kelly, Michael Griffin, Kane Esien, Solveig Felton, Helge Müller-Bunz, Grace G. Morgan|2022|Cryst.Growth Des.|22|6429|doi:10.1021/acs.cgd.2c00468
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2bqxvv
title: CCDC 2166988: Experimental Crystal Structure Determination

description: Related Article: Conor T. Kelly, Michael Griffin, Kane Esien, Solveig Felton, Helge Müller-Bunz, Grace G. Morgan|2022|Cryst.Growth Des.|22|6429|doi:10.1021/acs.cgd.2c00468
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2bqxww
title: CCDC 2166989: Experimental Crystal Structure Determination

description: Related Article: Conor T. Kelly, Michael Griffin, Kane Esien, Solveig Felton, Helge Müller-Bunz, Grace G. Morgan|2022|Cryst.Growth Des.|22|6429|doi:10.1021/acs.cgd.2c00468
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2bqxxx
title: CCDC 2166990: Experimental Crystal Structure Determination

description: Related Article: Conor T. Kelly, Michael Griffin, Kane Esien, Solveig Felton, Helge Müller-Bunz, Grace G. Morgan|2022|Cryst.Growth Des.|22|6429|doi:10.1021/acs.cgd.2c00468
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2bqxyy
title: CCDC 2166991: Experimental Crystal Structure Determination

description: Related Article: Conor T. Kelly, Michael Griffin, Kane Esien, Solveig Felton, Helge Müller-Bunz, Grace G. Morgan|2022|Cryst.Growth Des.|22|6429|doi:10.1021/acs.cgd.2c00468
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.