cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.7232999
title: Environmental complexity; a buffer against stress in the domestic chick.

description: We explore the hypothesis that provision of a complex environment during early life, better prepares birds to cope with stressful events as well as buffers them against future unpredictable stressful episodes. In this study, 96 one day old pullets were randomly distributed in eight pens (12 birds/pen). Half of the chicks (N=48) were assigned to a Complex Environment (CENV: with perches, a dark brooder etc.) the others to a Simple Environment (SENV: without enrichment features). Half of the birds from each of these treatments were assigned to a No Stress (NSTR, 33ºC) or to an acute Cold Stress (CSTR, 18-20ºC) treatment during six hours on their second day of life. At four weeks of age, chicks with these four different backgrounds were exposed to an Intermittent Stressful Challenges Protocol (ISCP). In an immunological test, indicative of proinflammatory status Phytohemagglutinin-<em>P</em><em> (PHA-P), the </em>response of CSTR birds was ameliorated by rearing chicks in a CENV, as they had a similar response to NSTR chicks and a significantly better pro-inflammatory response than those CSTR birds reared in a SENV (five days after the CSTR treatment was applied). A similar better response when coping with new challenges (the ISCP) was observed in birds reared in a CENV compared to those from a SENV. Birds reared in the CENV had a lower H/L ratio (after the ISCP) than birds reared in SENV, independently of whether or not they had been exposed to CSTR early in life. No effects of stress on general behaviour were detected, however, the provision of a CENV increased resting behaviour, which may have favoured stress recover. Additionally, we found that exposure to cold stress at an early age might have rendered birds more vulnerable to future stressful events. CSTR birds had lower humoral immune responses (sheep red blood cells induced antibodies) after ISCP and started using elevated structures in the CENV later compared to their NSTR conspecifics. Our study reflects the importance of the early provision of a CENV in commercial conditions to reduce negative stress-related effects and improve welfare related indicators. [I1]What do you prefer indicators or variables?
DOI: 10.7284/119673
title: GNSS (Global Navigation Satellite System) data collected during research cruise SP1525 using a Furuno GP-90D instrument system onboard the platform RV Robert Gordon Sproul

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7232999.v1
title: Environmental complexity; a buffer against stress in the domestic chick.

description: We explore the hypothesis that provision of a complex environment during early life, better prepares birds to cope with stressful events as well as buffers them against future unpredictable stressful episodes. In this study, 96 one day old pullets were randomly distributed in eight pens (12 birds/pen). Half of the chicks (N=48) were assigned to a Complex Environment (CENV: with perches, a dark brooder etc.) the others to a Simple Environment (SENV: without enrichment features). Half of the birds from each of these treatments were assigned to a No Stress (NSTR, 33ºC) or to an acute Cold Stress (CSTR, 18-20ºC) treatment during six hours on their second day of life. At four weeks of age, chicks with these four different backgrounds were exposed to an Intermittent Stressful Challenges Protocol (ISCP). In an immunological test, indicative of proinflammatory status Phytohemagglutinin-<em>P</em><em> (PHA-P), the </em>response of CSTR birds was ameliorated by rearing chicks in a CENV, as they had a similar response to NSTR chicks and a significantly better pro-inflammatory response than those CSTR birds reared in a SENV (five days after the CSTR treatment was applied). A similar better response when coping with new challenges (the ISCP) was observed in birds reared in a CENV compared to those from a SENV. Birds reared in the CENV had a lower H/L ratio (after the ISCP) than birds reared in SENV, independently of whether or not they had been exposed to CSTR early in life. No effects of stress on general behaviour were detected, however, the provision of a CENV increased resting behaviour, which may have favoured stress recover. Additionally, we found that exposure to cold stress at an early age might have rendered birds more vulnerable to future stressful events. CSTR birds had lower humoral immune responses (sheep red blood cells induced antibodies) after ISCP and started using elevated structures in the CENV later compared to their NSTR conspecifics. Our study reflects the importance of the early provision of a CENV in commercial conditions to reduce negative stress-related effects and improve welfare related indicators. [I1]What do you prefer indicators or variables?
DOI: 10.6084/m9.figshare.7232984
title: MRI images of TBI mouse model for Assessment of therapeutic effects of Monocyte depletion

description: Compressed image file set
DOI: 10.7284/120821
title: GNSS (Global Navigation Satellite System) data collected during research cruise SP1525 using a Ashtech ADU2 instrument system onboard the platform RV Robert Gordon Sproul

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7232984.v1
title: MRI images of TBI mouse model for Assessment of therapeutic effects of Monocyte depletion

description: Compressed image file set
DOI: 10.6084/m9.figshare.7232978
title: The AKR1D1*36 (rs1872930) allelic variant is independently associated with Clopidogrel treatment outcome

description: These data were collected with the purpose to study the the association between AKR1D1 and CYP2C19 polymorphisms with MACCE in a cardiovascular patient cohort from the Republic of North Macedonia.<br>These data, among others, formed the basis for the PhD thesis by Dr. Kapedanovska-Nestorovska
DOI: 10.7284/120822
title: GNSS (Global Navigation Satellite System) data collected during research cruise SP1525 using a Garmin GPS-17HVS instrument system onboard the platform RV Robert Gordon Sproul

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/120859
title: Gyrocompass data collected during research cruise SP1525 using a Furuno Furuno SC-30 instrument system onboard the platform RV Robert Gordon Sproul

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7232978.v1
title: The AKR1D1*36 (rs1872930) allelic variant is independently associated with Clopidogrel treatment outcome in Acute Coronary Syndrome patients

description: These raw data were collected with the purpose to study the the association between AKR1D1 and CYP2C19 polymorphisms with MACCE in a ACS patient cohort from the Republic of Macedonia.<br>These data, among others, formed the basis for the PhD thesis by Dr. Kapedanovska-Nestorovska
DOI: 10.6084/m9.figshare.7232978.v2
title: The AKR1D1*36 (rs1872930) allelic variant is independently associated with Clopidogrel treatment outcome

description: These data were collected with the purpose to study the the association between AKR1D1 and CYP2C19 polymorphisms with MACCE in a cardiovascular patient cohort from the Republic of North Macedonia.<br>These data, among others, formed the basis for the PhD thesis by Dr. Kapedanovska-Nestorovska
DOI: 10.7284/119675
title: Meteorological Station data collected during research cruise SP1525 using a SIO MET-System instrument system onboard the platform RV Robert Gordon Sproul

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/119674
title: Winch data collected during research cruise SP1525 using a Markey DEYSH-3 instrument system onboard the platform RV Robert Gordon Sproul

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/119677
title: ADCP (Acoustic Doppler Current Profiler) data collected during research cruise SP1526 using a Hawaii UHDAS instrument system onboard the platform RV Robert Gordon Sproul

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/124427
title: CTD (Conductivity, Temperature, Depth) data collected during research cruise SP1526 using a Sea-Bird SBE-911+ instrument system onboard the platform RV Robert Gordon Sproul

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/119678
title: GNSS (Global Navigation Satellite System) data collected during research cruise SP1526 using a Furuno GP-90D instrument system onboard the platform RV Robert Gordon Sproul

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/120823
title: GNSS (Global Navigation Satellite System) data collected during research cruise SP1526 using a Ashtech ADU2 instrument system onboard the platform RV Robert Gordon Sproul

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/120824
title: GNSS (Global Navigation Satellite System) data collected during research cruise SP1526 using a Garmin GPS-17HVS instrument system onboard the platform RV Robert Gordon Sproul

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/120860
title: Gyrocompass data collected during research cruise SP1526 using a Furuno Furuno SC-30 instrument system onboard the platform RV Robert Gordon Sproul

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/119681
title: Meteorological Station data collected during research cruise SP1526 using a SIO MET-System instrument system onboard the platform RV Robert Gordon Sproul

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/119679
title: Singlebeam Echosounder data collected during research cruise SP1526 using a Knudsen 320B/R instrument system onboard the platform RV Robert Gordon Sproul

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/119680
title: Winch data collected during research cruise SP1526 using a Markey DEYSH-3 instrument system onboard the platform RV Robert Gordon Sproul

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/119683
title: ADCP (Acoustic Doppler Current Profiler) data collected during research cruise SP1527 using a Hawaii UHDAS instrument system onboard the platform RV Robert Gordon Sproul

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/124428
title: CTD (Conductivity, Temperature, Depth) data collected during research cruise SP1527 using a Sea-Bird SBE-911+ instrument system onboard the platform RV Robert Gordon Sproul

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/119684
title: GNSS (Global Navigation Satellite System) data collected during research cruise SP1527 using a Furuno GP-90D instrument system onboard the platform RV Robert Gordon Sproul

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/120825
title: GNSS (Global Navigation Satellite System) data collected during research cruise SP1527 using a Ashtech ADU2 instrument system onboard the platform RV Robert Gordon Sproul

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7232819
title: Depletion of Nesprin-2 is associated with an embryonic lethal phenotype in mice

description: Nesprin-2 is a nuclear envelope component and provides a link between cytoskeletal components of the cytoplasm and the nucleoplasm. Several isoforms are generated from its gene <i>Syne2</i>. Loss of the largest isoform Nesprin-2 Giant in mice is associated with a skin phenotype and altered wound healing, loss of C-terminal isoforms in mice leads to cardiomyopathies and neurological defects. Here we attempted to establish mice with an inducible knockout of all Nesprin-2 isoforms by inserting shRNA encoding sequences targeting the N- and C-terminus into the ROSA26 locus of mice. This caused early embryonic death of the animals harboring the mutant allele, which was presumably due to leaky expression of the shRNAs. Mutant embryos were only observed before E13. They had an altered appearance and were smaller in size than their wild type littermates. From this we conclude that the Nesprin-2 gene function is crucial during embryonic growth, differentiation and organogenesis.
DOI: 10.7284/120826
title: GNSS (Global Navigation Satellite System) data collected during research cruise SP1527 using a Garmin GPS-17HVS instrument system onboard the platform RV Robert Gordon Sproul

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7232819.v2
title: Depletion of Nesprin-2 is associated with an embryonic lethal phenotype in mice

description: Nesprin-2 is a nuclear envelope component and provides a link between cytoskeletal components of the cytoplasm and the nucleoplasm. Several isoforms are generated from its gene <i>Syne2</i>. Loss of the largest isoform Nesprin-2 Giant in mice is associated with a skin phenotype and altered wound healing, loss of C-terminal isoforms in mice leads to cardiomyopathies and neurological defects. Here we attempted to establish mice with an inducible knockout of all Nesprin-2 isoforms by inserting shRNA encoding sequences targeting the N- and C-terminus into the ROSA26 locus of mice. This caused early embryonic death of the animals harboring the mutant allele, which was presumably due to leaky expression of the shRNAs. Mutant embryos were only observed before E13. They had an altered appearance and were smaller in size than their wild type littermates. From this we conclude that the Nesprin-2 gene function is crucial during embryonic growth, differentiation and organogenesis.
DOI: 10.6084/m9.figshare.7232819.v1
title: Depletion of Nesprin-2 is associated with an embryonic lethal phenotype in mice

description: Nesprin-2 is a nuclear envelope component and provides a link between cytoskeletal components of the cytoplasm and the nucleoplasm. Several isoforms are generated from its gene <i>Syne2</i>. Loss of the largest isoform Nesprin-2 Giant in mice is associated with a skin phenotype and altered wound healing, loss of C-terminal isoforms in mice leads to cardiomyopathies and neurological defects. Here we attempted to establish mice with an inducible knockout of all Nesprin-2 isoforms by inserting shRNA encoding sequences targeting the N- and C-terminus into the ROSA26 locus of mice. This caused early embryonic death of the animals harboring the mutant allele, which was presumably due to leaky expression of the shRNAs. Mutant embryos were only observed before E13. They had an altered appearance and were smaller in size than their wild type littermates. From this we conclude that the Nesprin-2 gene function is crucial during embryonic growth, differentiation and organogenesis.
DOI: 10.7284/120861
title: Gyrocompass data collected during research cruise SP1527 using a Furuno Furuno SC-30 instrument system onboard the platform RV Robert Gordon Sproul

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/119686
title: Meteorological Station data collected during research cruise SP1527 using a SIO MET-System instrument system onboard the platform RV Robert Gordon Sproul

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/119685
title: Winch data collected during research cruise SP1527 using a Markey DEYSH-3 instrument system onboard the platform RV Robert Gordon Sproul

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/119688
title: ADCP (Acoustic Doppler Current Profiler) data collected during research cruise SP1528 using a Hawaii UHDAS instrument system onboard the platform RV Robert Gordon Sproul

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/124429
title: CTD (Conductivity, Temperature, Depth) data collected during research cruise SP1528 using a Sea-Bird SBE-911+ instrument system onboard the platform RV Robert Gordon Sproul

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/119689
title: GNSS (Global Navigation Satellite System) data collected during research cruise SP1528 using a Furuno GP-90D instrument system onboard the platform RV Robert Gordon Sproul

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/120827
title: GNSS (Global Navigation Satellite System) data collected during research cruise SP1528 using a Ashtech ADU2 instrument system onboard the platform RV Robert Gordon Sproul

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/120828
title: GNSS (Global Navigation Satellite System) data collected during research cruise SP1528 using a Garmin GPS-17HVS instrument system onboard the platform RV Robert Gordon Sproul

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/120862
title: Gyrocompass data collected during research cruise SP1528 using a Furuno Furuno SC-30 instrument system onboard the platform RV Robert Gordon Sproul

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/119692
title: Meteorological Station data collected during research cruise SP1528 using a SIO MET-System instrument system onboard the platform RV Robert Gordon Sproul

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/119690
title: Singlebeam Echosounder data collected during research cruise SP1528 using a Knudsen 320B/R instrument system onboard the platform RV Robert Gordon Sproul

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/119691
title: Winch data collected during research cruise SP1528 using a Markey DEYSH-3 instrument system onboard the platform RV Robert Gordon Sproul

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/119694
title: ADCP (Acoustic Doppler Current Profiler) data collected during research cruise SP1529 using a Hawaii UHDAS instrument system onboard the platform RV Robert Gordon Sproul

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/119695
title: GNSS (Global Navigation Satellite System) data collected during research cruise SP1529 using a Furuno GP-90D instrument system onboard the platform RV Robert Gordon Sproul

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/120829
title: GNSS (Global Navigation Satellite System) data collected during research cruise SP1529 using a Ashtech ADU2 instrument system onboard the platform RV Robert Gordon Sproul

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/120830
title: GNSS (Global Navigation Satellite System) data collected during research cruise SP1529 using a Garmin GPS-17HVS instrument system onboard the platform RV Robert Gordon Sproul

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/120863
title: Gyrocompass data collected during research cruise SP1529 using a Furuno Furuno SC-30 instrument system onboard the platform RV Robert Gordon Sproul

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/119698
title: Meteorological Station data collected during research cruise SP1529 using a SIO MET-System instrument system onboard the platform RV Robert Gordon Sproul

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/119696
title: Singlebeam Echosounder data collected during research cruise SP1529 using a Knudsen 320B/R instrument system onboard the platform RV Robert Gordon Sproul

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/119700
title: ADCP (Acoustic Doppler Current Profiler) data collected during research cruise SP1530 using a Hawaii UHDAS instrument system onboard the platform RV Robert Gordon Sproul

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/124430
title: CTD (Conductivity, Temperature, Depth) data collected during research cruise SP1530 using a Sea-Bird SBE-911+ instrument system onboard the platform RV Robert Gordon Sproul

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/119701
title: GNSS (Global Navigation Satellite System) data collected during research cruise SP1530 using a Furuno GP-90D instrument system onboard the platform RV Robert Gordon Sproul

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/120831
title: GNSS (Global Navigation Satellite System) data collected during research cruise SP1530 using a Ashtech ADU2 instrument system onboard the platform RV Robert Gordon Sproul

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/120832
title: GNSS (Global Navigation Satellite System) data collected during research cruise SP1530 using a Garmin GPS-17HVS instrument system onboard the platform RV Robert Gordon Sproul

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/120864
title: Gyrocompass data collected during research cruise SP1530 using a Furuno Furuno SC-30 instrument system onboard the platform RV Robert Gordon Sproul

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/119704
title: Meteorological Station data collected during research cruise SP1530 using a SIO MET-System instrument system onboard the platform RV Robert Gordon Sproul

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/119702
title: Singlebeam Echosounder data collected during research cruise SP1530 using a Knudsen 320B/R instrument system onboard the platform RV Robert Gordon Sproul

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/119703
title: Winch data collected during research cruise SP1530 using a Markey DEYSH-3 instrument system onboard the platform RV Robert Gordon Sproul

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/119706
title: ADCP (Acoustic Doppler Current Profiler) data collected during research cruise SP1531 using a Hawaii UHDAS instrument system onboard the platform RV Robert Gordon Sproul

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/119707
title: GNSS (Global Navigation Satellite System) data collected during research cruise SP1531 using a Furuno GP-90D instrument system onboard the platform RV Robert Gordon Sproul

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/120833
title: GNSS (Global Navigation Satellite System) data collected during research cruise SP1531 using a Ashtech ADU2 instrument system onboard the platform RV Robert Gordon Sproul

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/120834
title: GNSS (Global Navigation Satellite System) data collected during research cruise SP1531 using a Garmin GPS-17HVS instrument system onboard the platform RV Robert Gordon Sproul

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/120865
title: Gyrocompass data collected during research cruise SP1531 using a Furuno Furuno SC-30 instrument system onboard the platform RV Robert Gordon Sproul

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/119709
title: Meteorological Station data collected during research cruise SP1531 using a SIO MET-System instrument system onboard the platform RV Robert Gordon Sproul

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/119708
title: Winch data collected during research cruise SP1531 using a Markey DEYSH-3 instrument system onboard the platform RV Robert Gordon Sproul

description: Original (unprocessed) data collected during a Field_expedition