cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.5281/zenodo.7612263
title: Hematopoietic progenitor cell liabilities and alarmins S100A8/A9-related inflammaging associate with frailty and predict poor cardiovascular outcomes in older adults

description: Frailty affects the physical, cognitive, and social domains exposing older adults to an increased risk of cardiovascular disease and death. The mechanisms linking frailty and cardiovascular outcomes are mostly unknown. Here, we studied the association of abundance (flow cytometry) and gene expression profile (RNAseq) of stem/progenitor cells (HSPCs) and molecular markers of inflammaging (ELISA) with the cardiorespiratory phenotype and prospective adverse events of individuals classified according to levels of frailty. Two cohorts of older adults were enrolled in the study. In a cohort of pre-frail 35 individuals (average age: 75 years), a physical frailty score above the median identified subjects with initial alterations in cardiorespiratory function. RNA sequencing revealed S100A8/A9 upregulation in HSPCs from the bone marrow (&gt;10-fold) and peripheral blood (&gt;200-fold) of individuals with greater physical frailty. Moreover higher frailty was associated with increased alarmins S100A8/A9 and inflammatory cytokines in peripheral blood. We then studied a cohort of 104 more frail individuals (average age: 81 years) with multidomain health deficits. Reduced levels of circulating HSPCs and increased S100A8/A9 concentrations were independently associated with the frailty index. Remarkably, low HSPCs and high S100A8/A9 simultaneously predicted major adverse cardiovascular events at 1-year follow-up after adjustment for age and frailty index. In conclusion, inflammaging characterized by alarmin and pro-inflammatory cytokines in pre-frail individuals is mirrored by the pauperization of HSPCs in frail older people with comorbidities. S100A8/A9 is upregulated within HSPCs, identifying a phenotype that associates with poor cardiovascular outcomes.
DOI: 10.5281/zenodo.7612262
title: Hematopoietic progenitor cell liabilities and alarmins S100A8/A9-related inflammaging associate with frailty and predict poor cardiovascular outcomes in older adults

description: Frailty affects the physical, cognitive, and social domains exposing older adults to an increased risk of cardiovascular disease and death. The mechanisms linking frailty and cardiovascular outcomes are mostly unknown. Here, we studied the association of abundance (flow cytometry) and gene expression profile (RNAseq) of stem/progenitor cells (HSPCs) and molecular markers of inflammaging (ELISA) with the cardiorespiratory phenotype and prospective adverse events of individuals classified according to levels of frailty. Two cohorts of older adults were enrolled in the study. In a cohort of pre-frail 35 individuals (average age: 75 years), a physical frailty score above the median identified subjects with initial alterations in cardiorespiratory function. RNA sequencing revealed S100A8/A9 upregulation in HSPCs from the bone marrow (&gt;10-fold) and peripheral blood (&gt;200-fold) of individuals with greater physical frailty. Moreover higher frailty was associated with increased alarmins S100A8/A9 and inflammatory cytokines in peripheral blood. We then studied a cohort of 104 more frail individuals (average age: 81 years) with multidomain health deficits. Reduced levels of circulating HSPCs and increased S100A8/A9 concentrations were independently associated with the frailty index. Remarkably, low HSPCs and high S100A8/A9 simultaneously predicted major adverse cardiovascular events at 1-year follow-up after adjustment for age and frailty index. In conclusion, inflammaging characterized by alarmin and pro-inflammatory cytokines in pre-frail individuals is mirrored by the pauperization of HSPCs in frail older people with comorbidities. S100A8/A9 is upregulated within HSPCs, identifying a phenotype that associates with poor cardiovascular outcomes.
DOI: 10.6084/m9.figshare.22032276
title: Prognosis of chronic Chagas heart disease and other pending clinical challenges

description: In this chapter, the main prognostic markers of Chagas heart disease are addressed, with an emphasis on the most recent findings and questions, establishing the basis for a broad discussion of recommendations and new approaches to managing Chagas cardiopathy. The main biological and genetic markers and the contribution of the electrocardiogram, echocardiogram and cardiac magnetic resonance are presented. We also discuss the most recent therapeutic proposals for heart failure, thromboembolism and arrhythmias, as well as current experience in heart transplantation in patients suffering from severe Chagas cardiomyopathy. The clinical and epidemiological challenges introduced by acute Chagas disease due to oral contamination are discussed. In addition, we highlight the importance of ageing and comorbidities in influencing the outcome of chronic Chagas heart disease. Finally, we discuss the importance of public policies, the vital role of funding agencies, universities, the scientific community and health professionals, and the application of new technologies in finding solutions for better management of Chagas heart disease.
DOI: 10.6084/m9.figshare.22032276.v1
title: Prognosis of chronic Chagas heart disease and other pending clinical challenges

description: In this chapter, the main prognostic markers of Chagas heart disease are addressed, with an emphasis on the most recent findings and questions, establishing the basis for a broad discussion of recommendations and new approaches to managing Chagas cardiopathy. The main biological and genetic markers and the contribution of the electrocardiogram, echocardiogram and cardiac magnetic resonance are presented. We also discuss the most recent therapeutic proposals for heart failure, thromboembolism and arrhythmias, as well as current experience in heart transplantation in patients suffering from severe Chagas cardiomyopathy. The clinical and epidemiological challenges introduced by acute Chagas disease due to oral contamination are discussed. In addition, we highlight the importance of ageing and comorbidities in influencing the outcome of chronic Chagas heart disease. Finally, we discuss the importance of public policies, the vital role of funding agencies, universities, the scientific community and health professionals, and the application of new technologies in finding solutions for better management of Chagas heart disease.
DOI: 10.6084/m9.figshare.22032275.v1
title: Morphological characteristics of the left gastric, common hepatic and splenic arteries. A descriptive study in human cadaveric specimens

description: ABSTRACT Objective: to evaluate the morphology of the branches of celiac trunk (CT), left gastric (LGA), common hepatic (CHA), and splenic (SA) arteries in cadaveric specimens from a sample of a Colombian population. Methods: descriptive cross-sectional study of 26 blocks from the abdominal upper segment of human cadavers who underwent forensic autopsies at the Instituto de Medicina Legal at Bucaramanga, Colombia. The vascular beds of the celiac trunk were, subsequently, perfused with a semi-synthetic resin. Results: the diameters of LGA, CHA, and SA were 3.6±0.8mm, 5,2±1.2mm, and 5.9±1.0mm, respectively. Statistically, LGA and SA were different (p=&lt;0.001). SA followed a linear trajectory in 8 (31%) samples, slightly tortuous in 4 (15%), and tortuous in 14 (54%). The tortuosity index was 1.25±0.18. Of the branches of CHA, the proper hepatic artery (PHA) had 4.8±1.2mm in diameter and 18.8±9.1mm in length, whereas the gastroduodenal artery (GDdA) had 4.1±0.8mm. In 2 cases (7.7%), an accessory hepatic artery from the LGA was found to supply perfusion to the left hepatic lobe. Finally, in 2 cases (7.7%) the SA came independently from the abdominal aorta. Conclusion: the observed emergence incidence of the CT branches from the same level as reported in the literature is lower. The characterization, along with their variants, of LGA, CHA, and SA must be considered in surgical procedures in the upper abdominal segment, to avoid iatrogenic complications.
DOI: 10.6084/m9.figshare.22032275
title: Morphological characteristics of the left gastric, common hepatic and splenic arteries. A descriptive study in human cadaveric specimens

description: ABSTRACT Objective: to evaluate the morphology of the branches of celiac trunk (CT), left gastric (LGA), common hepatic (CHA), and splenic (SA) arteries in cadaveric specimens from a sample of a Colombian population. Methods: descriptive cross-sectional study of 26 blocks from the abdominal upper segment of human cadavers who underwent forensic autopsies at the Instituto de Medicina Legal at Bucaramanga, Colombia. The vascular beds of the celiac trunk were, subsequently, perfused with a semi-synthetic resin. Results: the diameters of LGA, CHA, and SA were 3.6±0.8mm, 5,2±1.2mm, and 5.9±1.0mm, respectively. Statistically, LGA and SA were different (p=&lt;0.001). SA followed a linear trajectory in 8 (31%) samples, slightly tortuous in 4 (15%), and tortuous in 14 (54%). The tortuosity index was 1.25±0.18. Of the branches of CHA, the proper hepatic artery (PHA) had 4.8±1.2mm in diameter and 18.8±9.1mm in length, whereas the gastroduodenal artery (GDdA) had 4.1±0.8mm. In 2 cases (7.7%), an accessory hepatic artery from the LGA was found to supply perfusion to the left hepatic lobe. Finally, in 2 cases (7.7%) the SA came independently from the abdominal aorta. Conclusion: the observed emergence incidence of the CT branches from the same level as reported in the literature is lower. The characterization, along with their variants, of LGA, CHA, and SA must be considered in surgical procedures in the upper abdominal segment, to avoid iatrogenic complications.
DOI: 10.6084/m9.figshare.19959847
title: The multidimensional comprehension of Chagas disease. Contributions, approaches, challenges and opportunities from and beyond the Information, Education and Communication field

description: Chagas is a complex, multidimensional phenomenon in which political, economic, environmental, biomedical, epidemiological, psychological, and sociocultural factors intersect. Nonetheless, the hegemonic conceptualisation has long envisioned Chagas as primarily a biomedical question, while ignoring or downplaying the other dimensions, and this limited view has reinforced the disease’s long neglect. Integrating the multiple dimensions of the problem into a coherent approach adapted to field realities and needs represents an immense challenge, but the payoff is more effective and sustainable experiences, with higher social awareness, increased case detection and follow-up, improved adherence to care, and integrated participation of various actors from multiple action levels. Information, Education, and Communication (IEC) initiatives have great potential for impact in the implementation of multidimensional programs of prevention and control successfully customised to the diverse and complex contexts where Chagas disease persists.
DOI: 10.6084/m9.figshare.19959847.v1
title: The multidimensional comprehension of Chagas disease. Contributions, approaches, challenges and opportunities from and beyond the Information, Education and Communication field

description: Chagas is a complex, multidimensional phenomenon in which political, economic, environmental, biomedical, epidemiological, psychological, and sociocultural factors intersect. Nonetheless, the hegemonic conceptualisation has long envisioned Chagas as primarily a biomedical question, while ignoring or downplaying the other dimensions, and this limited view has reinforced the disease’s long neglect. Integrating the multiple dimensions of the problem into a coherent approach adapted to field realities and needs represents an immense challenge, but the payoff is more effective and sustainable experiences, with higher social awareness, increased case detection and follow-up, improved adherence to care, and integrated participation of various actors from multiple action levels. Information, Education, and Communication (IEC) initiatives have great potential for impact in the implementation of multidimensional programs of prevention and control successfully customised to the diverse and complex contexts where Chagas disease persists.
DOI: 10.6084/m9.figshare.6741431
title: COCI CSV dataset of the provenance information of all the citation data

description: This dataset contains the provenance information (in CSV format) of all the citation data included in COCI, released on 23 January 2023. In particular, each line of the CSV file defines a citation, and includes the following information: <strong>[field "oci"]</strong> the Open Citation Identifier (OCI) for the citation; <strong>[field "snapshot"]</strong> the identifier of the snapshot; <strong>[field "agent"]</strong> the name of the agent that have created the citation data; <strong>[field "source"]</strong> the URL of the source dataset from where the citation data have been extracted; <strong>[field "created"]</strong> the creation time of the citation data. <strong>[field "invalidated"] </strong>the start of the destruction, cessation, or expiry of an existing entity by an activity; <strong>[field "description"] </strong>a textual description of the activity made; <strong>[field "update"] </strong>the UPDATE SPARQL query that keeps track of which metadata have been modified. The size of the zipped archive is 20 GB, while the size of the unzipped CSV file is 330 GB.Additional information about COCI are available at <sub>official webpage</sub>.
DOI: 10.6084/m9.figshare.6741431.v19
title: COCI CSV dataset of the provenance information of all the citation data

description: This dataset contains the provenance information (in CSV format) of all the citation data included in COCI, released on 23 January 2023. In particular, each line of the CSV file defines a citation, and includes the following information: <strong>[field "oci"]</strong> the Open Citation Identifier (OCI) for the citation; <strong>[field "snapshot"]</strong> the identifier of the snapshot; <strong>[field "agent"]</strong> the name of the agent that have created the citation data; <strong>[field "source"]</strong> the URL of the source dataset from where the citation data have been extracted; <strong>[field "created"]</strong> the creation time of the citation data. <strong>[field "invalidated"] </strong>the start of the destruction, cessation, or expiry of an existing entity by an activity; <strong>[field "description"] </strong>a textual description of the activity made; <strong>[field "update"] </strong>the UPDATE SPARQL query that keeps track of which metadata have been modified. The size of the zipped archive is 20 GB, while the size of the unzipped CSV file is 330 GB.Additional information about COCI are available at <sub>official webpage</sub>.
DOI: 10.6084/m9.figshare.6741431.v18
title: COCI CSV dataset of the provenance information of all the citation data

description: This dataset contains the provenance information (in CSV format) of all the citation data included in COCI, released on 31 October 2022. In particular, each line of the CSV file defines a citation, and includes the following information: <strong>[field "oci"]</strong> the Open Citation Identifier (OCI) for the citation; <strong>[field "snapshot"]</strong> the identifier of the snapshot; <strong>[field "agent"]</strong> the name of the agent that have created the citation data; <strong>[field "source"]</strong> the URL of the source dataset from where the citation data have been extracted; <strong>[field "created"]</strong> the creation time of the citation data. <strong>[field "invalidated"] </strong>the start of the destruction, cessation, or expiry of an existing entity by an activity; <strong>[field "description"] </strong>a textual description of the activity made; <strong>[field "update"] </strong>the UPDATE SPARQL query that keeps track of which metadata have been modified. The size of the zipped archive is 18.92 GB, while the size of the unzipped CSV file is 313 GB.Additional information about COCI can be retrieved in the <sub>official webpage</sub>.
DOI: 10.6084/m9.figshare.19959859
title: Parasitological, serological and molecular diagnosis of acute and chronic Chagas disease: from field to laboratory

description: There is no consensus on the diagnostic algorithms for many scenarios of Trypanosoma cruzi infection, which hinders the establishment of governmental guidelines in endemic and non-endemic countries. In the acute phase, parasitological methods are currently employed, and standardised surrogate molecular tests are being introduced to provide higher sensitivity and less operator-dependence. In the chronic phase, IgG-based serological assays are currently used, but if a single assay does not reach the required accuracy, PAHO/WHO recommends at least two immunological tests with different technical principles. Specific algorithms are applied to diagnose congenital infection, screen blood and organ donors or conduct epidemiological surveys. Detecting Chagas disease reactivation in immunosuppressed individuals is an area of increasing interest. Due to its neglect, enhancing access to diagnosis of patients at risk of suffering T. cruzi infection should be a priority at national and regional levels.
DOI: 10.6084/m9.figshare.19959859.v1
title: Parasitological, serological and molecular diagnosis of acute and chronic Chagas disease: from field to laboratory

description: There is no consensus on the diagnostic algorithms for many scenarios of Trypanosoma cruzi infection, which hinders the establishment of governmental guidelines in endemic and non-endemic countries. In the acute phase, parasitological methods are currently employed, and standardised surrogate molecular tests are being introduced to provide higher sensitivity and less operator-dependence. In the chronic phase, IgG-based serological assays are currently used, but if a single assay does not reach the required accuracy, PAHO/WHO recommends at least two immunological tests with different technical principles. Specific algorithms are applied to diagnose congenital infection, screen blood and organ donors or conduct epidemiological surveys. Detecting Chagas disease reactivation in immunosuppressed individuals is an area of increasing interest. Due to its neglect, enhancing access to diagnosis of patients at risk of suffering T. cruzi infection should be a priority at national and regional levels.
DOI: 10.6084/m9.figshare.21900186
title: IMPACTS OF RUNNING ON JOINTS

description: ABSTRACT Introduction Running is a competitive sports activity based on speed. Its training methods aim to improve performance and physique but may lead to sports joint injuries. It is important to clarify the relationship between training methods and sports rehabilitation, including the influence of training methods on the quality of life, such as joint health. Objective Explore the relationship between the influence of running training methods on joints and their sports rehabilitation. Methods 44 running athletes were randomly divided into two groups. The joint and rehabilitation indices of the hip, knee, and ankle joints were recorded and statistically analyzed. Results The range of flexion and extension in the sagittal plane, the range of internal and external rotation in the horizontal plane, and the running performance of the knee joints of the athletes who received the variable speed running training were improved, indicating that the running training mode improves the joint performance and sports rehabilitation level of the athletes. Conclusion The appropriate running training method has a beneficial effect on the state of the joints in its athletes, including in the rehabilitation process. This effect is reflected in the physical parameters and the athlete’s competitive ability. Level of evidence II; Therapeutic studies - investigation of treatment outcomes.
DOI: 10.6084/m9.figshare.21900186.v1
title: IMPACTS OF RUNNING ON JOINTS

description: ABSTRACT Introduction Running is a competitive sports activity based on speed. Its training methods aim to improve performance and physique but may lead to sports joint injuries. It is important to clarify the relationship between training methods and sports rehabilitation, including the influence of training methods on the quality of life, such as joint health. Objective Explore the relationship between the influence of running training methods on joints and their sports rehabilitation. Methods 44 running athletes were randomly divided into two groups. The joint and rehabilitation indices of the hip, knee, and ankle joints were recorded and statistically analyzed. Results The range of flexion and extension in the sagittal plane, the range of internal and external rotation in the horizontal plane, and the running performance of the knee joints of the athletes who received the variable speed running training were improved, indicating that the running training mode improves the joint performance and sports rehabilitation level of the athletes. Conclusion The appropriate running training method has a beneficial effect on the state of the joints in its athletes, including in the rehabilitation process. This effect is reflected in the physical parameters and the athlete’s competitive ability. Level of evidence II; Therapeutic studies - investigation of treatment outcomes.
DOI: 10.6084/m9.figshare.6741446
title: COCI N-Triples dataset of the provenance information of all the citation data

description: This dataset contains the provenance information (in N-Triples format) of all the citation data included in COCI, released on 23 January 2023. In particular, any citation in the dataset includes the following provenance information: <strong>[citation IRI]</strong> the Open Citation Identifier (OCI) for the citation, defined in the final part of the URL identifying the citation (https://w3id.org/oc/index/coci/ci/[OCI]);; <strong>[property "prov:wasAttributedTo"]</strong> the IRI of the agent that have created the citation data; <strong>[property "prov:hadPrimarySource"]</strong> the IRI of the source dataset from where the citation data have been extracted; <strong>[property "prov:generatedAtTime"]</strong> the creation time of the citation data. <strong>[propert "prov:invalidatedAtTime"]</strong> the start of the destruction, cessation, or expiry of an existing entity by an activity. <strong>[property "oco:hasUpdateQuery"] </strong>the UPDATE SPARQL query that keeps track of which metadata have been modified. The size of the zipped archive is 78 GB, while the size of the unzipped N-Triples file is 3.3 TB.Additional information about COCI are available at <sub>official webpage</sub>.
DOI: 10.6084/m9.figshare.6741446.v18
title: COCI N-Triples dataset of the provenance information of all the citation data

description: This dataset contains the provenance information (in N-Triples format) of all the citation data included in COCI, released on 31 October 2022. In particular, any citation in the dataset includes the following provenance information: <strong>[citation IRI]</strong> the Open Citation Identifier (OCI) for the citation, defined in the final part of the URL identifying the citation (https://w3id.org/oc/index/coci/ci/[OCI]);; <strong>[property "prov:wasAttributedTo"]</strong> the IRI of the agent that have created the citation data; <strong>[property "prov:hadPrimarySource"]</strong> the IRI of the source dataset from where the citation data have been extracted; <strong>[property "prov:generatedAtTime"]</strong> the creation time of the citation data. <strong>[propert "prov:invalidatedAtTime"]</strong> the start of the destruction, cessation, or expiry of an existing entity by an activity. <strong>[property "oco:hasUpdateQuery"] </strong>the UPDATE SPARQL query that keeps track of which metadata have been modified. The size of the zipped archive is 73.9 GB, while the size of the unzipped N-Triples file is 3.15 TB.Additional information about COCI can be retrieved in the <sub>official webpage</sub>.