cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.25919/21dw-hq86
title: Parkes observations for project P1068 semester 2020APRS_31

description: In the fast-moving world of Fast Radio Bursts (FRBs), the key question of what fraction (as high as 100%?) of FRBs emit repeat bursts remains unanswered. Of order 10 repeating FRBs are now known, and their spectro-temporal properties hint at differences with apparently non-repeating bursts - but poor statistics preclude a definitive diagnosis. FRB 180301 is a promising source for further study for multiple reasons: it is the first repeating FRB seen by the FAST telescope, and has the second-highest rotation measure ever seen for a FRB (after the original repeater, FRB121102). We request Parkes observations with the UWL to characterise the broadband emission properties of this FRB, with the following key goals: to constrain the repetition rate, identify any variation of pulse characteristics over time, and provide insight into the emission mechanisms. In its initial detection, FRB 180301 was poorly fit by regular Faraday rotation models, and showed significant circular polarization, which may indicate the progenitor is embedded in an extreme magneto-ionic environment with complex field structure that has not been seen before. These observations will generate a large data volume. We will use the Medusa backend in parallel with the Breakthrough Listen data recorder (BL), and will transfer data to BL immediately after observations.These data will be used by P. Kumar to prototype a FRB pipeline for the UWL, that will be made broadly available for similar studies.
DOI: 10.25919/49my-yp24
title: Parkes observations for project P971 semester 2020APRS_07

description: We propose timing observations of the relativistic pulsar - white-dwarf binary PSR J1141-6545. This unique system offers access to a wide range of physics, from relativistic phenomena through pulsar emission cone studies, to the structure and distribution of interstellar plasma along our line-of-sight. The recently installed Parkes Ultra Wide Band Low Frequency (UWL) receiver has opened up the possibility of performing first-ever studies of its orbital dynamics at high temporal resolution and study of the effects of the intra-binary medium on the dispersion and polarisation of the pulse profile. Our analysis of data obtained to date suggests that the pulsar would precess away from our line-of-sight in the next 3-5 years. Hence, regular observations are crucial to maximizing its science outcome
DOI: 10.25919/6q2a-2441
title: Parkes observations for project P1068 semester 2020APRS_32

description: In the fast-moving world of Fast Radio Bursts (FRBs), the key question of what fraction (as high as 100%?) of FRBs emit repeat bursts remains unanswered. Of order 10 repeating FRBs are now known, and their spectro-temporal properties hint at differences with apparently non-repeating bursts - but poor statistics preclude a definitive diagnosis. FRB 180301 is a promising source for further study for multiple reasons: it is the first repeating FRB seen by the FAST telescope, and has the second-highest rotation measure ever seen for a FRB (after the original repeater, FRB121102). We request Parkes observations with the UWL to characterise the broadband emission properties of this FRB, with the following key goals: to constrain the repetition rate, identify any variation of pulse characteristics over time, and provide insight into the emission mechanisms. In its initial detection, FRB 180301 was poorly fit by regular Faraday rotation models, and showed significant circular polarization, which may indicate the progenitor is embedded in an extreme magneto-ionic environment with complex field structure that has not been seen before. These observations will generate a large data volume. We will use the Medusa backend in parallel with the Breakthrough Listen data recorder (BL), and will transfer data to BL immediately after observations.These data will be used by P. Kumar to prototype a FRB pipeline for the UWL, that will be made broadly available for similar studies.
DOI: 10.25919/hwa7-6h27
title: Parkes observations for project P1068 semester 2020APRS_33

description: In the fast-moving world of Fast Radio Bursts (FRBs), the key question of what fraction (as high as 100%?) of FRBs emit repeat bursts remains unanswered. Of order 10 repeating FRBs are now known, and their spectro-temporal properties hint at differences with apparently non-repeating bursts - but poor statistics preclude a definitive diagnosis. FRB 180301 is a promising source for further study for multiple reasons: it is the first repeating FRB seen by the FAST telescope, and has the second-highest rotation measure ever seen for a FRB (after the original repeater, FRB121102). We request Parkes observations with the UWL to characterise the broadband emission properties of this FRB, with the following key goals: to constrain the repetition rate, identify any variation of pulse characteristics over time, and provide insight into the emission mechanisms. In its initial detection, FRB 180301 was poorly fit by regular Faraday rotation models, and showed significant circular polarization, which may indicate the progenitor is embedded in an extreme magneto-ionic environment with complex field structure that has not been seen before. These observations will generate a large data volume. We will use the Medusa backend in parallel with the Breakthrough Listen data recorder (BL), and will transfer data to BL immediately after observations.These data will be used by P. Kumar to prototype a FRB pipeline for the UWL, that will be made broadly available for similar studies.
DOI: 10.25919/9nt0-f514
title: Parkes observations for project P1068 semester 2020APRS_34

description: In the fast-moving world of Fast Radio Bursts (FRBs), the key question of what fraction (as high as 100%?) of FRBs emit repeat bursts remains unanswered. Of order 10 repeating FRBs are now known, and their spectro-temporal properties hint at differences with apparently non-repeating bursts - but poor statistics preclude a definitive diagnosis. FRB 180301 is a promising source for further study for multiple reasons: it is the first repeating FRB seen by the FAST telescope, and has the second-highest rotation measure ever seen for a FRB (after the original repeater, FRB121102). We request Parkes observations with the UWL to characterise the broadband emission properties of this FRB, with the following key goals: to constrain the repetition rate, identify any variation of pulse characteristics over time, and provide insight into the emission mechanisms. In its initial detection, FRB 180301 was poorly fit by regular Faraday rotation models, and showed significant circular polarization, which may indicate the progenitor is embedded in an extreme magneto-ionic environment with complex field structure that has not been seen before. These observations will generate a large data volume. We will use the Medusa backend in parallel with the Breakthrough Listen data recorder (BL), and will transfer data to BL immediately after observations.These data will be used by P. Kumar to prototype a FRB pipeline for the UWL, that will be made broadly available for similar studies.
DOI: 10.25919/d5cx-fz32
title: Parkes observations for project P1068 semester 2020APRS_35

description: In the fast-moving world of Fast Radio Bursts (FRBs), the key question of what fraction (as high as 100%?) of FRBs emit repeat bursts remains unanswered. Of order 10 repeating FRBs are now known, and their spectro-temporal properties hint at differences with apparently non-repeating bursts - but poor statistics preclude a definitive diagnosis. FRB 180301 is a promising source for further study for multiple reasons: it is the first repeating FRB seen by the FAST telescope, and has the second-highest rotation measure ever seen for a FRB (after the original repeater, FRB121102). We request Parkes observations with the UWL to characterise the broadband emission properties of this FRB, with the following key goals: to constrain the repetition rate, identify any variation of pulse characteristics over time, and provide insight into the emission mechanisms. In its initial detection, FRB 180301 was poorly fit by regular Faraday rotation models, and showed significant circular polarization, which may indicate the progenitor is embedded in an extreme magneto-ionic environment with complex field structure that has not been seen before. These observations will generate a large data volume. We will use the Medusa backend in parallel with the Breakthrough Listen data recorder (BL), and will transfer data to BL immediately after observations.These data will be used by P. Kumar to prototype a FRB pipeline for the UWL, that will be made broadly available for similar studies.
DOI: 10.25919/5kgz-8971
title: Parkes observations for project P456 semester 2020APRS_17

description: The Parkes Pulsar Timing Array (PPTA) project has three primary goals: (a) detection of gravitational waves from astronomical sources, (b) establishment of a pulsar timescale, and (c) improvement of our understanding of Solar-system dynamics. The PPTA is the oldest of three international pulsar timing groups. We have the smallest telescope and the smallest group, but the best measurements and the best results. Our bound on the strength of the incoherent gravitational wave background is the only bound which significantly constrains theoretical models. We have maintained our leading position because: we have the southern sky; we have a small but well-focussed group; we have the best-calibrated receivers; and we have been able to observe with an almost regular cadence of 15 to 20 days over a wide bandwidth. With this proposal we aim to maintain our pre-eminent position in the field. Unlike most observing proposals, this is a continuing proposal for which the observations will continue to improve bounds on ultra-low-frequency gravitational waves until they are finally detected. Continued Parkes observations will remain valuable at least until the first stage of the SKA is able to improve on our sensitivity and observing cadence. Even after the gravitational wave background is detected we will want to continue observations in support of the nascent field of gravitational wave astronomy!
DOI: 10.25919/mbm6-1z36
title: Parkes observations for project P1014 semester 2020APRS_06

description: The spatial distribution of neutral gas is important for understanding the interstellar medium (ISM), its evolution, and star formation. However, the distribution of Tiny Scale Atomic Structures (TSAS), especially the extremely small scale structures with spatial scales ranging from a few to hundreds of AU is largely unexplored. The formation and evolution of TSAS are still unknown. Multi-epoch observations of HI absorption against pulsars are a tested, practical observational method to probe the TSAS. Based on our observations in the 2019 APRS semester, we successfully processed baseband data and detected the HI absorption variation at over 4-months towards B1557-50. PSR B1451-68 is another ideal source to trace the TSAS because of the intervening cold gas. We thus propose one-epoch observation towards B1557-50 which should be as early in the semester as possible, and two-epoch observations towards B1451-68 to be separated by about 5 months, for monitoring the HI absorption variations and probing structures on a range of scales. This will better constrain the characteristics of variations in HI absorption, thus contribute significantly to understanding the origin of TSAS.
DOI: 10.25500/edata.bham.00000577
title: Research data supporting “Analysis of the Air Pollution Climate of a Central Urban Roadside Supersite: London, Marylebone Road”
DOI: 10.25345/c5qr44
title: MassIVE MSV000086549 - Bursera spp and Copal and Archaeological samples
title: Discrimination of resins from botanically certified samples of Mexican Bursera together with commercial resins and archaeological samples
DOI: 10.6084/m9.figshare.13325375
title: Supplementary Material for: Downregulation of miRNA-451a Promotes the Differentiation of CD4+ T Cells towards Th2 Cells by Upregulating ETS1 in Childhood Asthma

description: Children exposed to common aeroallergens may develop asthma that progresses into adulthood. Inflammation regulated by T helper 2 (Th2) cells, a specific subpopulation of CD4+ T lymphocytes, is involved in asthmatic injury. Herein, our microarray data indicated that microRNA-451a-5p (miRNA-451a) expression decreased by 4.6-fold and ETS proto-oncogene 1 (ETS1) increased by 2.2-fold in the peripheral blood lymphocytes isolated from asthmatic children (<i>n</i> = 4) as compared to control individuals (<i>n</i> = 4). The negative correlation between miRNA-451a and ETS1 was further validated in 40 CD4+ T cell samples (10 healthy vs. 30 asthmatic samples). In vitro, naïve CD4+ T cells isolated from control individuals were cultured under Th2 cell polarizing condition. miRNA-451a expression decreased while ETS1 increased in CD4+ T cells in the setting of Th2 cell polarization. Moreover, miRNA-451a knockdown enhanced Th2 cell polarization – cells positive for both GATA3 (GATA binding protein 3, a Th2-transcription factor) and CD4 increased, and the generation of Th2 cell cytokines, interleukin (IL)5 and IL13, increased. In contrast, miRNA-451a overexpression inhibited Th2 cell differentiation. Interestingly, dual-Luciferase assay proved ETS1 as a novel target of miRNA-451a. Moreover, enforced expression of ETS1 partially restored miRNA-451a-induced inhibition of IL5 and IL13, and increased the GATA3+CD4+ cell population. Collectively, our work demonstrates that downregulation of miRNA-451a upregulates ETS1 expression in CD4+ T cells, which may contribute to Th2 cell differentiation in pediatric asthma.
DOI: 10.25345/c5kz1t
title: MassIVE MSV000086550 - GNPS - Human Skin Microbiome Isolates
title: Human skin microbe isolates grown in TSB media. Extracts obtained by SPE Oasis HLB 96-well plates and recovered with 100% MeOH. Extracts were resuspended with 200uL 80% MeOH containing 1uM amitriptyline as internal standard. LC-MS/MS performed in an UltiMate 3000 UPLC system (Thermo Scientific) using a Kinetex 1.7 um C18 reversed phase UHPLC column (50 X 2.1 mm) and Maxis Impact Q-TOF mass spectrometer (Bruker Daltonics) equipped with ESI source. Data was acquired in positive ion mode. Further details regarding human skin isolates included in this dataset in: https://microbiomejournal.biomedcentral.com/articles/10.1186/s40168-020-00831-y
DOI: 10.17632/5hjyy6z436.1
title: Dataset of land surface temperature, near-infrared and short-wave infrared reflectance for estimation of water availability in vegetation

description: This dataset contains measurements of LST, NIR and SWIR reflectance of soybean, corn and barley taken in field campaigns in central Argentine Pampas (La Campana, 37°17' S, 58°56' W) and laboratory with a ST PRO Raytek (8-14µm) and a spectrometer SVC HR-1024i (0.35 and 2.5 µm). Also, data of relative water content of leaves measured in laboratory during the dehydration process are included.
DOI: 10.17632/mtdww9hd3m.1
title: AutoSpill: a method for calculating spillover coefficients in high-parameter flow cytometry

description: Biological utility of AutoSpill. Downstream analyses of data compensated by either the traditional compensation algorithm or AutoSpill. (a) Plots were prepared and compensated using FlowJo v.10.6, using either the default traditional algorithm or uploading the spillover matrix generated by AutoSpill. Representative flow cytometry plots illustrating errors corrected by AutoSpill (first and second column, MM3 dataset; third and fourth column, MM2 dataset). (b-e) All plots were prepared from the same FCS files and compensated using FlowJo v.10.7, using either the traditional algorithm or the AutoSpill option. (b) Hierarchical gating for CD4+CD8+CD25+ lymphocytes, using data compensated by the traditional algorithm or AutoSpill (MM3 dataset). (c) The CD4+CD25+ population was backgated to identify the source of population loss in the traditional algorithm (MM3 dataset). (d) MHCII expression on known negative cells (CD4 T cells), known positive cells (CD11b+ splenocytes), and microglia (MM4 dataset). Percent positive was thresholded using CD4 T cells as the negative. MHCII knockout microglia were used as a “true negative" staining control. (e) Foxp3GFP expression on known bimodal cells (CD4+ splenocytes) and CD11b+ macrophages (MM5 dataset). The positive population was thresholded using the negative CD4 T cell peak. Wildtype mice, without the GFP transgene, were used as a “true negative" staining control. This dataset includes the spillover matrices (traditional and AutoSpill) used in this analysis.
DOI: 10.17632/jydf92g979.1
title: Data_Study-Shared Picture Book Reading-Math Questions

description: These are the data of the study entitled: Preschool teachers’ questions during shared picture book reading in the domain of early mathematics: The contribution of type of picture book and teachers’ professional knowledge and beliefs.
DOI: 10.17632/zwrcvtjn6n.1
title: A missing link in the evolution of dasytine soft-winged flower beetles from Cretaceous Charentese amber (Coleoptera: Melyridae)

description: Full-resolution image stack (TIFF) and model in STL format.
DOI: 10.17632/4ypj4xxp68.8
title: The description of the model for "Molecular mechanisms of action determine inhibition of paroxysmal depolarizing shifts by NMDA receptor antagonists in rat cortical neurons"

description: The program code, executable files and full list of model parameters and settings used for the modelling of the paroxizmal depolorizing shift in the pyramydal cells and fast-spiking interneurons in prefrontal cortex
DOI: 10.17632/mcsypbk6nz.3
title: JSLE and healthy control immune phenotype
DOI: 10.17632/5yhxtvcgyy.1
title: Data - Pinpointing the implications of Big Five Personality Factors in moderating adjunctive antidepressant treatment response in a comparative study of esketamine and racemic ketamine for treatment-resistant depression.

description: The prevalence of resistance to treatment with antidepressants remains high among patients with Major Depressive Disorder. Several studies have shown that ketamine/esketamine appears to be a very promising approach to treatment-resistant depression (TRD) and examining personality dimensions based on the theory of Goldberg's Big Five factors of personality have attracted increasing attention in moderating antidepressant response. This is a randomized, double-blind, active-controlled, bicentre, non-inferiority clinical trial, with two parallel groups. A total of 63 individuals, 18 years or older, with major depression characterized as treatment-resistant, were randomly assigned to a 40-min single intravenous infusion of ketamine 0.5 mg/kg (n=29) or esketamine 0.25 mg/kg (n=34). The NEO-FFI-R was used to assess the personality dimensions and MADRS was used to assess response, both were performed at baseline, at 24 hours and at 7 days following the single infusion of investigational products. In the logistic regression model, among the five personality factors only openness demonstrated statistically significant association with antidepressant response, as increased. Openness was associated with increased likelihood of response to treatment. GEE analysis comparing personality scores, across time and response to treatment showed reduction of neuroticism over time. Present findings suggest that the openness domain moderates ketamine/esketamine response in TRD.
DOI: 10.17632/znfgfhpp5b.2
title: Northern hemisphere soil geochemistry
DOI: 10.17632/fzrbvkn26z.1
title: SecBPMN2BC case studies evaluation

description: This dataset contains the original diagrams of three case studies, defined using SecBPMN2, and the result diagram created using SecBPMN2BC modelling language. For each case study we provide a small description, the original diagram and the final result. Birth certificate This case study is about the release of a birth certificate by a municipality in a Greek city. The busines process is executed when a citizen applies for the creation of a copy of the birth certificate to the municipality. The municipality examines the request and release to the citizen its birth certificate. We slightly modified the business process by adding security and privity annotations and by correcting some incoherencies. Teleconsultation This case study is about a teleconsultation of a pediatric patient, i.e., an interview of a patient in a remote location. In particular, this is the case of a teleconsultation between an Italian and Spanish hospital. The family of the pediatric patient asks for the availability of the doctor that, if it is available, ask the consent to the pediatric patient. After that the doctor interviews the patient, consults his/her health record and give him a report. In this case we modify the business process adding few privity annotations, and correcting incoherencies. Televisit This case study is about a televisit, i.e., a visit of a pediatric patient by a specialized group, that is external to the patient’s hospital, in a remote location. The process starts with the pediatric patient that ask and sets and appointment. The hospital staff request the consent to the family, interviews the patient and ask for a consultation to an external specialized group. The group checks its availability, visits the patients and send a report to the hospital staff. The hospital staff compiles a final report that send to the pediatric patient. We slighthly modify the process adding privity annotations and security annotation where needed. We solved incoherencies and refined the consent management.
DOI: 10.17632/7bd5bhmhmz.2
title: Genome-scale identification of SARS-CoV-2 and pan-coronavirus host factor networks. Schneider et al.

description: The COVID-19 pandemic has claimed the lives of more than one million people worldwide. The causative agent, SARS-CoV-2, is a member of the Coronaviridae family, which are viruses that cause respiratory infections of varying severity. The cellular host factors and pathways co-opted by SARS- CoV-2 and other coronaviruses in the execution of their life cycles remain ill-defined. To develop an extensive compendium of host factors required for infection by SARS-CoV-2 and three seasonal coronaviruses (HCoV-OC43, HCoV-NL63, and HCoV-229E), we performed parallel genome-scale CRISPR knockout screens. These screens uncovered multiple host factors and pathways with pan- coronavirus and virus-specific functional roles, including major dependency on glycosaminoglycan biosynthesis, SREBP signaling, BMP signaling, and glycosylphosphatidylinositol biosynthesis, as well as a requirement for several poorly characterized proteins. We identified an absolute requirement for the VTT-domain containing protein TMEM41B for infection by SARS-CoV-2 and three seasonal coronaviruses. This human Coronaviridae host factor compendium represents a rich resource to develop new therapeutic strategies for acute COVID-19 and potential future coronavirus spillover events.
DOI: 10.17632/f47bm47bcw.3
title: RNA-seq and miRNA-seq data from pharmacological inhibition of the G9a/GLP histone methyltransferase complex with UNC0642

description: Growing evidence demonstrates the epigenetic modulation as a key event in Alzheimer’s disease (AD) pathology. Furthermore, recent data suggests that the epigenetic regulation by the methyltransferase G9a is a crucial mechanism involved in learning and memory formation. Taking this into account, the present study provides genomics data from pharmacological intervention with UNC0642, a potent and selective G9a/GLP in SAMP8 mice, a model of Alzheimer’s disease (AD). We have generated novel RNA-seq and miRNA-seq data for three groups, healthy SAMR1, SAMP8 control and SAMP8 treated with UNC0642 (5mg/Kg). Thus, the new data can be used to find miRNA regulation, and the mRNA’s modified in AD under G9a/GLP inhibition.