cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.34808/kpjn-0y12
title: Hepatic fibrosis - Male, 53 - Tissue image [5250730010644881]

description: This is the histopathological image of LIVER AND INTRAHEPATIC BILE DUCTS tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format. The detailed information about the patient, sample, and diagnosis are as follows: Patient:Age: 53Clinical description: Liver fibrosis. Congenital haemochromatosis.Gender: MaleDiagnosis:Classification: ICD-10_10-20Classification code: Chapter XI - Diseases of the digestive systemDiagnosis: Hepatic fibrosisResult of the histopathological examination: In the examined oligopyoptate (one partially fragmented section) fragments of the enlarged biliary spaces are usually present, containing a large number of inflammatory cells, mainly mononuclear. Within the above-mentioned enlarged spaces, there are features of pronounced fibrogenesis, characterized by intense portal and periportal fibrosis with the formation of portal-portal fibrous bridges, it is possible that also portal-central, with the presence of a single regenerative nodule. In some portal spaces accumulating elements of collagen connective tissue, there is a clear proliferation of bile ducts.
Large groups of enlarged hepatocytes are observed, especially those located near the portal spaces, depositing iron in the form of haemosiderin, and stimulated Borowicz-Kupffer cells accumulating hemosiderin.
In places, there are features of mixed steatosis of quite numerous hepatocytes, with a predominance of large droplets.

The microscopic image of the examined material indicates the process of intense fibrosis of on the base of congenital haemochromatosis, although coexistence of another liver pathology cannot be ruled out.Sample:Material: FFPECollecting method: Surgical specimenTopography: DIGESTIVE ORGANSOrgan: LIVER AND INTRAHEPATIC BILE DUCTSTissue: LiverType of staining: positive/HCStaining: Perls (Prussian Blue)Antibody: Not applicableTechnology:Equipment: Pannoramic 250 3DHistechLens: 20xOrganization:Source: Medical University Gdańsk
DOI: 10.34808/2e99-xg31
title: Hepatic fibrosis - Male, 53 - Tissue image [5250730010643121]

description: This is the histopathological image of LIVER AND INTRAHEPATIC BILE DUCTS tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format. The detailed information about the patient, sample, and diagnosis are as follows: Patient:Age: 53Clinical description: Liver fibrosis. Congenital haemochromatosis.Gender: MaleDiagnosis:Classification: ICD-10_10-20Classification code: Chapter XI - Diseases of the digestive systemDiagnosis: Hepatic fibrosisResult of the histopathological examination: In the examined oligopyoptate (one partially fragmented section) fragments of the enlarged biliary spaces are usually present, containing a large number of inflammatory cells, mainly mononuclear. Within the above-mentioned enlarged spaces, there are features of pronounced fibrogenesis, characterized by intense portal and periportal fibrosis with the formation of portal-portal fibrous bridges, it is possible that also portal-central, with the presence of a single regenerative nodule. In some portal spaces accumulating elements of collagen connective tissue, there is a clear proliferation of bile ducts.
Large groups of enlarged hepatocytes are observed, especially those located near the portal spaces, depositing iron in the form of haemosiderin, and stimulated Borowicz-Kupffer cells accumulating hemosiderin.
In places, there are features of mixed steatosis of quite numerous hepatocytes, with a predominance of large droplets.

The microscopic image of the examined material indicates the process of intense fibrosis of on the base of congenital haemochromatosis, although coexistence of another liver pathology cannot be ruled out.Sample:Material: FFPECollecting method: Surgical specimenTopography: DIGESTIVE ORGANSOrgan: LIVER AND INTRAHEPATIC BILE DUCTSTissue: LiverType of staining: positive/HCStaining: Masson TrichromeAntibody: Not applicableTechnology:Equipment: Pannoramic 250 3DHistechLens: 20xOrganization:Source: Medical University Gdańsk
DOI: 10.34808/3sg2-j612
title: Hepatic fibrosis - Female, 52 - Tissue image [5250730010648641]

description: This is the histopathological image of LIVER AND INTRAHEPATIC BILE DUCTS tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format. The detailed information about the patient, sample, and diagnosis are as follows: Patient:Age: 52Clinical description: Liver cirrhosis.Gender: FemaleDiagnosis:Classification: ICD-10_10-20Classification code: Chapter XI - Diseases of the digestive systemDiagnosis: Hepatic fibrosisResult of the histopathological examination: (Liver oligobiopsy in 2 sections, including 1 partially fragmented.)
More than half of the portal spaces are significantly or very significantly dilated, contain an abundant and very abundant number of mononuclear inflammatory cells, mainly lymphocytic, with an admixture of not very numerous eosinophils, separating fairly well from the lobule borderline; the remaining portal spaces were usually slightly widened. Within the most dilated portal spaces, lymph nodes forming, quite numerous HPCs-line cells differentiating into hepatocytes, and bile duct proliferation (well shown in IHC staining for CK7 and CK19) are visible; the basement membrane of some bile ducts is focally crossed by individual lymphocytic cells.
In the examined biopsy there are features of marked intensified periportal fibrosis with formation of incomplete fibrous bridges, and not too numerous but quite thick fibrous bridges of the portal-portal type and a single portal-central type bridge; there are also minor foci of intramedullary fibrosis.
In fever, not too many hepatocytes are found, showing the features of: cytoplasmic degeneration or intracellular bile stagnation, or glycogenic degeneration of the testes.
The microscopic image of the examined biopsy shows progressive fibrosis of the organ (without cirrhosis).
However, taking into account the morphological and clinical picture and the results of laboratory tests [positive anti-mitochondrial antibodies (AMA) in the blood serum], the onset of primary cirrhosis (PBC) cannot be ruled out.
IHC: SMA - numerous activated hepatic stellate cells;
Turnbull's blue (for the presence of Fe ++) - negative.Sample:Material: FFPECollecting method: Surgical specimenTopography: DIGESTIVE ORGANSOrgan: LIVER AND INTRAHEPATIC BILE DUCTSTissue: LiverType of staining: positive/IHCStaining: Not applicableAntibody: CK 19Technology:Equipment: Pannoramic 250 3DHistechLens: 20xOrganization:Source: Medical University Gdańsk
DOI: 10.34808/y4k5-2230
title: Hepatic fibrosis - Female, 52 - Tissue image [5250730010641261]

description: This is the histopathological image of LIVER AND INTRAHEPATIC BILE DUCTS tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format. The detailed information about the patient, sample, and diagnosis are as follows: Patient:Age: 52Clinical description: Liver cirrhosis.Gender: FemaleDiagnosis:Classification: ICD-10_10-20Classification code: Chapter XI - Diseases of the digestive systemDiagnosis: Hepatic fibrosisResult of the histopathological examination: (Liver oligobiopsy in 2 sections, including 1 partially fragmented.)
More than half of the portal spaces are significantly or very significantly dilated, contain an abundant and very abundant number of mononuclear inflammatory cells, mainly lymphocytic, with an admixture of not very numerous eosinophils, separating fairly well from the lobule borderline; the remaining portal spaces were usually slightly widened. Within the most dilated portal spaces, lymph nodes forming, quite numerous HPCs-line cells differentiating into hepatocytes, and bile duct proliferation (well shown in IHC staining for CK7 and CK19) are visible; the basement membrane of some bile ducts is focally crossed by individual lymphocytic cells.
In the examined biopsy there are features of marked intensified periportal fibrosis with formation of incomplete fibrous bridges, and not too numerous but quite thick fibrous bridges of the portal-portal type and a single portal-central type bridge; there are also minor foci of intramedullary fibrosis.
In fever, not too many hepatocytes are found, showing the features of: cytoplasmic degeneration or intracellular bile stagnation, or glycogenic degeneration of the testes.
The microscopic image of the examined biopsy shows progressive fibrosis of the organ (without cirrhosis).
However, taking into account the morphological and clinical picture and the results of laboratory tests [positive anti-mitochondrial antibodies (AMA) in the blood serum], the onset of primary cirrhosis (PBC) cannot be ruled out.
IHC: SMA - numerous activated hepatic stellate cells;
Turnbull's blue (for the presence of Fe ++) - negative.Sample:Material: FFPECollecting method: Surgical specimenTopography: DIGESTIVE ORGANSOrgan: LIVER AND INTRAHEPATIC BILE DUCTSTissue: LiverType of staining: positive/IHCStaining: Not applicableAntibody: SMATechnology:Equipment: Pannoramic 250 3DHistechLens: 20xOrganization:Source: Medical University Gdańsk
DOI: 10.34808/adtj-9f25
title: Neoplasm, malignant - Female, 62 - Tissue image [5250730010641331]

description: This is the histopathological image of BRAIN tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format. The detailed information about the patient, sample, and diagnosis are as follows: Patient:Age: 62Clinical description: CNS tumor.Gender: FemaleDiagnosis:Classification: ICD-O_3.2Classification code: NEOPLASMS, NOSDiagnosis: Neoplasm, malignantResult of the histopathological examination: Bone trabeculae with features of sclerotization and pericellular fibrosis.
A cartilage lesion with features of nuclear atypia is visible. The morphological picture may correspond to a low-grade chondrosarcoma.Sample:Material: FFCollecting method: Surgical specimenTopography: EYE, BRAIN AND OTHER PARTS OF CENTRAL NERVOUS SYSTEMOrgan: BRAINTissue: Temporal lobeType of staining: positive/HEStaining: Hematoxylin & eosinAntibody: Not applicableTechnology:Equipment: Pannoramic 250 3DHistechLens: 20xOrganization:Source: Medical University Gdańsk
DOI: 10.34808/kysz-dj33
title: Hepatic fibrosis - Male, 53 - Tissue image [5250730010643171]

description: This is the histopathological image of LIVER AND INTRAHEPATIC BILE DUCTS tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format. The detailed information about the patient, sample, and diagnosis are as follows: Patient:Age: 53Clinical description: Liver fibrosis. Congenital haemochromatosis.Gender: MaleDiagnosis:Classification: ICD-10_10-20Classification code: Chapter XI - Diseases of the digestive systemDiagnosis: Hepatic fibrosisResult of the histopathological examination: In the examined oligopyoptate (one partially fragmented section) fragments of the enlarged biliary spaces are usually present, containing a large number of inflammatory cells, mainly mononuclear. Within the above-mentioned enlarged spaces, there are features of pronounced fibrogenesis, characterized by intense portal and periportal fibrosis with the formation of portal-portal fibrous bridges, it is possible that also portal-central, with the presence of a single regenerative nodule. In some portal spaces accumulating elements of collagen connective tissue, there is a clear proliferation of bile ducts.
Large groups of enlarged hepatocytes are observed, especially those located near the portal spaces, depositing iron in the form of haemosiderin, and stimulated Borowicz-Kupffer cells accumulating hemosiderin.
In places, there are features of mixed steatosis of quite numerous hepatocytes, with a predominance of large droplets.

The microscopic image of the examined material indicates the process of intense fibrosis of on the base of congenital haemochromatosis, although coexistence of another liver pathology cannot be ruled out.Sample:Material: FFPECollecting method: Surgical specimenTopography: DIGESTIVE ORGANSOrgan: LIVER AND INTRAHEPATIC BILE DUCTSTissue: LiverType of staining: positive/IHCStaining: Not applicableAntibody: CK 7Technology:Equipment: Pannoramic 250 3DHistechLens: 20xOrganization:Source: Medical University Gdańsk
DOI: 10.34808/2dyb-1w19
title: Hepatic fibrosis - Female, 52 - Tissue image [5250730010641821]

description: This is the histopathological image of LIVER AND INTRAHEPATIC BILE DUCTS tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format. The detailed information about the patient, sample, and diagnosis are as follows: Patient:Age: 52Clinical description: Liver cirrhosis.Gender: FemaleDiagnosis:Classification: ICD-10_10-20Classification code: Chapter XI - Diseases of the digestive systemDiagnosis: Hepatic fibrosisResult of the histopathological examination: (Liver oligobiopsy in 2 sections, including 1 partially fragmented.)
More than half of the portal spaces are significantly or very significantly dilated, contain an abundant and very abundant number of mononuclear inflammatory cells, mainly lymphocytic, with an admixture of not very numerous eosinophils, separating fairly well from the lobule borderline; the remaining portal spaces were usually slightly widened. Within the most dilated portal spaces, lymph nodes forming, quite numerous HPCs-line cells differentiating into hepatocytes, and bile duct proliferation (well shown in IHC staining for CK7 and CK19) are visible; the basement membrane of some bile ducts is focally crossed by individual lymphocytic cells.
In the examined biopsy there are features of marked intensified periportal fibrosis with formation of incomplete fibrous bridges, and not too numerous but quite thick fibrous bridges of the portal-portal type and a single portal-central type bridge; there are also minor foci of intramedullary fibrosis.
In fever, not too many hepatocytes are found, showing the features of: cytoplasmic degeneration or intracellular bile stagnation, or glycogenic degeneration of the testes.
The microscopic image of the examined biopsy shows progressive fibrosis of the organ (without cirrhosis).
However, taking into account the morphological and clinical picture and the results of laboratory tests [positive anti-mitochondrial antibodies (AMA) in the blood serum], the onset of primary cirrhosis (PBC) cannot be ruled out.
IHC: SMA - numerous activated hepatic stellate cells;
Turnbull's blue (for the presence of Fe ++) - negative.Sample:Material: FFPECollecting method: Surgical specimenTopography: DIGESTIVE ORGANSOrgan: LIVER AND INTRAHEPATIC BILE DUCTSTissue: LiverType of staining: positive/HCStaining: Sirius RedAntibody: Not applicableTechnology:Equipment: Pannoramic 250 3DHistechLens: 20xOrganization:Source: Medical University Gdańsk
DOI: 10.34808/xywf-vx15
title: Hepatic fibrosis - Female, 52 - Tissue image [525073001064761]

description: This is the histopathological image of LIVER AND INTRAHEPATIC BILE DUCTS tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format. The detailed information about the patient, sample, and diagnosis are as follows: Patient:Age: 52Clinical description: Liver cirrhosis.Gender: FemaleDiagnosis:Classification: ICD-10_10-20Classification code: Chapter XI - Diseases of the digestive systemDiagnosis: Hepatic fibrosisResult of the histopathological examination: (Liver oligobiopsy in 2 sections, including 1 partially fragmented.)
More than half of the portal spaces are significantly or very significantly dilated, contain an abundant and very abundant number of mononuclear inflammatory cells, mainly lymphocytic, with an admixture of not very numerous eosinophils, separating fairly well from the lobule borderline; the remaining portal spaces were usually slightly widened. Within the most dilated portal spaces, lymph nodes forming, quite numerous HPCs-line cells differentiating into hepatocytes, and bile duct proliferation (well shown in IHC staining for CK7 and CK19) are visible; the basement membrane of some bile ducts is focally crossed by individual lymphocytic cells.
In the examined biopsy there are features of marked intensified periportal fibrosis with formation of incomplete fibrous bridges, and not too numerous but quite thick fibrous bridges of the portal-portal type and a single portal-central type bridge; there are also minor foci of intramedullary fibrosis.
In fever, not too many hepatocytes are found, showing the features of: cytoplasmic degeneration or intracellular bile stagnation, or glycogenic degeneration of the testes.
The microscopic image of the examined biopsy shows progressive fibrosis of the organ (without cirrhosis).
However, taking into account the morphological and clinical picture and the results of laboratory tests [positive anti-mitochondrial antibodies (AMA) in the blood serum], the onset of primary cirrhosis (PBC) cannot be ruled out.
IHC: SMA - numerous activated hepatic stellate cells;
Turnbull's blue (for the presence of Fe ++) - negative.Sample:Material: FFPECollecting method: Surgical specimenTopography: DIGESTIVE ORGANSOrgan: LIVER AND INTRAHEPATIC BILE DUCTSTissue: LiverType of staining: positive/HCStaining: Masson TrichromeAntibody: Not applicableTechnology:Equipment: Pannoramic 250 3DHistechLens: 20xOrganization:Source: Medical University Gdańsk
DOI: 10.34808/eyk6-rr36
title: Hepatic fibrosis - Female, 52 - Tissue image [5250730010642031]

description: This is the histopathological image of LIVER AND INTRAHEPATIC BILE DUCTS tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format. The detailed information about the patient, sample, and diagnosis are as follows: Patient:Age: 52Clinical description: Liver cirrhosis.Gender: FemaleDiagnosis:Classification: ICD-10_10-20Classification code: Chapter XI - Diseases of the digestive systemDiagnosis: Hepatic fibrosisResult of the histopathological examination: (Liver oligobiopsy in 2 sections, including 1 partially fragmented.)
More than half of the portal spaces are significantly or very significantly dilated, contain an abundant and very abundant number of mononuclear inflammatory cells, mainly lymphocytic, with an admixture of not very numerous eosinophils, separating fairly well from the lobule borderline; the remaining portal spaces were usually slightly widened. Within the most dilated portal spaces, lymph nodes forming, quite numerous HPCs-line cells differentiating into hepatocytes, and bile duct proliferation (well shown in IHC staining for CK7 and CK19) are visible; the basement membrane of some bile ducts is focally crossed by individual lymphocytic cells.
In the examined biopsy there are features of marked intensified periportal fibrosis with formation of incomplete fibrous bridges, and not too numerous but quite thick fibrous bridges of the portal-portal type and a single portal-central type bridge; there are also minor foci of intramedullary fibrosis.
In fever, not too many hepatocytes are found, showing the features of: cytoplasmic degeneration or intracellular bile stagnation, or glycogenic degeneration of the testes.
The microscopic image of the examined biopsy shows progressive fibrosis of the organ (without cirrhosis).
However, taking into account the morphological and clinical picture and the results of laboratory tests [positive anti-mitochondrial antibodies (AMA) in the blood serum], the onset of primary cirrhosis (PBC) cannot be ruled out.
IHC: SMA - numerous activated hepatic stellate cells;
Turnbull's blue (for the presence of Fe ++) - negative.Sample:Material: FFPECollecting method: Surgical specimenTopography: DIGESTIVE ORGANSOrgan: LIVER AND INTRAHEPATIC BILE DUCTSTissue: LiverType of staining: positive/HCStaining: Perls (Prussian Blue)Antibody: Not applicableTechnology:Equipment: Pannoramic 250 3DHistechLens: 20xOrganization:Source: Medical University Gdańsk
DOI: 10.34808/je6e-7s76
title: Hepatic fibrosis - Female, 52 - Tissue image [5250730010646041]

description: This is the histopathological image of LIVER AND INTRAHEPATIC BILE DUCTS tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format. The detailed information about the patient, sample, and diagnosis are as follows: Patient:Age: 52Clinical description: Liver cirrhosis.Gender: FemaleDiagnosis:Classification: ICD-10_10-20Classification code: Chapter XI - Diseases of the digestive systemDiagnosis: Hepatic fibrosisResult of the histopathological examination: (Liver oligobiopsy in 2 sections, including 1 partially fragmented.)
More than half of the portal spaces are significantly or very significantly dilated, contain an abundant and very abundant number of mononuclear inflammatory cells, mainly lymphocytic, with an admixture of not very numerous eosinophils, separating fairly well from the lobule borderline; the remaining portal spaces were usually slightly widened. Within the most dilated portal spaces, lymph nodes forming, quite numerous HPCs-line cells differentiating into hepatocytes, and bile duct proliferation (well shown in IHC staining for CK7 and CK19) are visible; the basement membrane of some bile ducts is focally crossed by individual lymphocytic cells.
In the examined biopsy there are features of marked intensified periportal fibrosis with formation of incomplete fibrous bridges, and not too numerous but quite thick fibrous bridges of the portal-portal type and a single portal-central type bridge; there are also minor foci of intramedullary fibrosis.
In fever, not too many hepatocytes are found, showing the features of: cytoplasmic degeneration or intracellular bile stagnation, or glycogenic degeneration of the testes.
The microscopic image of the examined biopsy shows progressive fibrosis of the organ (without cirrhosis).
However, taking into account the morphological and clinical picture and the results of laboratory tests [positive anti-mitochondrial antibodies (AMA) in the blood serum], the onset of primary cirrhosis (PBC) cannot be ruled out.
IHC: SMA - numerous activated hepatic stellate cells;
Turnbull's blue (for the presence of Fe ++) - negative.Sample:Material: FFPECollecting method: Surgical specimenTopography: DIGESTIVE ORGANSOrgan: LIVER AND INTRAHEPATIC BILE DUCTSTissue: LiverType of staining: positive/IHCStaining: Not applicableAntibody: CK 7Technology:Equipment: Pannoramic 250 3DHistechLens: 20xOrganization:Source: Medical University Gdańsk