cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.25919/te1a-k492
title: Parkes observations for project P1006 semester 2019APRS_38

description: We propose observations with the ultra-wide-bandwidth, low-frequency receiver installed at the Parkes telescope to carry out the first ultra-high time resolution, coherently de-dispersed search for pulsars in globular clusters. We have chosen the 11 most likely clusters for new discoveries. These clusters all have at least three pulsars already known allowing us to have a precise estimate of the pulsar dispersion measures and our observations will provide the first ultra-wide-bandwidth observation of these pulsars. Our observing strategy will enable us to search for extremely narrow pulsars and even pulsars with sub-millisecond periods.
DOI: 10.6084/m9.figshare.14540223
title: Supplementary Material for: Plaque Longitudinal Heterogeneity in Morphology, Property, and Mechanobiology

description: <b><i>Background and Purpose:</i></b> The hemodynamic environment of an atherosclerotic plaque varies along the longitudinal direction. Investigating the changes in plaque morphology and its biomechanical environment along the longitudinal direction and their correlations will enhance our understanding of plaque progression and arterial remodeling. <b><i>Methods:</i></b> Six male patients with carotid stenosis &gt;70% were recruited. Multisequence high-resolution MRI was performed at the carotid bifurcation. Carotid endarterectomy was performed following MRI, and the plaque tissue was collected for histological and mechanical testing. Patient-specific biomechanical modeling and simulations were conducted to calculate the mechanical stresses (wall shear stress [WSS] and von Mises stress [VMS]). Changes in plaque cross-sectional morphology, WSS, and VMS as well as their correlations were evaluated. <b><i>Results:</i></b> Positive correlations were found between % stenosis and % inflammation (MA) (<i>p</i> = 0.019), % lipid area and % MA (<i>p</i> = 0.026), and % calcification area and VMS (<i>p</i> = 0.007). Negative correlations were found between VMS and % stenosis (<i>p</i> = 0.028) and VMS and average WSS (<i>p</i> = 0.034). Moreover, the peak stresses and neovessels were found to be in the shoulder regions. High-stress concentrations were found in the interface regions of the calcification and surrounding tissue, thereby increasing plaque vulnerability. <b><i>Conclusions:</i></b> Correlations between the morphology and stresses suggest that arterial remodeling is a dynamic interaction between mechanical environment and plaque progression resulting in plaque heterogeneity. Our finding indicates that plaque heterogeneity is associated with plaque progression and can be combined with mechanical stresses for identifying high-risk plaques.
DOI: 10.6084/m9.figshare.14540223.v1
title: Supplementary Material for: Plaque Longitudinal Heterogeneity in Morphology, Property, and Mechanobiology

description: <b><i>Background and Purpose:</i></b> The hemodynamic environment of an atherosclerotic plaque varies along the longitudinal direction. Investigating the changes in plaque morphology and its biomechanical environment along the longitudinal direction and their correlations will enhance our understanding of plaque progression and arterial remodeling. <b><i>Methods:</i></b> Six male patients with carotid stenosis &gt;70% were recruited. Multisequence high-resolution MRI was performed at the carotid bifurcation. Carotid endarterectomy was performed following MRI, and the plaque tissue was collected for histological and mechanical testing. Patient-specific biomechanical modeling and simulations were conducted to calculate the mechanical stresses (wall shear stress [WSS] and von Mises stress [VMS]). Changes in plaque cross-sectional morphology, WSS, and VMS as well as their correlations were evaluated. <b><i>Results:</i></b> Positive correlations were found between % stenosis and % inflammation (MA) (<i>p</i> = 0.019), % lipid area and % MA (<i>p</i> = 0.026), and % calcification area and VMS (<i>p</i> = 0.007). Negative correlations were found between VMS and % stenosis (<i>p</i> = 0.028) and VMS and average WSS (<i>p</i> = 0.034). Moreover, the peak stresses and neovessels were found to be in the shoulder regions. High-stress concentrations were found in the interface regions of the calcification and surrounding tissue, thereby increasing plaque vulnerability. <b><i>Conclusions:</i></b> Correlations between the morphology and stresses suggest that arterial remodeling is a dynamic interaction between mechanical environment and plaque progression resulting in plaque heterogeneity. Our finding indicates that plaque heterogeneity is associated with plaque progression and can be combined with mechanical stresses for identifying high-risk plaques.
DOI: 10.24376/rd.sgul.14501541
title: Indirect Effects of COVID-19 on Maternal, Neonatal, Child, Sexual and Reproductive Health Services in Kampala, Uganda

description: Background: COVID-19 has impacted global maternal, neonatal and child health outcomes. We hypothesised that the early, strict lockdown which severely limited the movements of individuals in Uganda will have impacted access to services.<br><br>Methods: An observational study, using routinely collected health data from Electronic Medical Records was carried out, utilising data from July 2019 to December 2020 in Kawempe district, Kampala. The mean and 95% confidence intervals were calculated pre-COVID (July 2019 – February 2020) and post-COVID (March-December 2020). The means were compared using t-tests, and the monthly totals analysed as to whether they lay within or outside the normal range, compared to the previous 9 months. <br>Results: Antenatal attendances decreased 96% in April 2020 and remain below pre-COVID levels. We found a rise in adverse pregnancy outcomes for Caesarean sections (5%), haemorrhages related to pregnancy (51%), stillbirths (31%) and low-birth-weight (162%) and premature infant births (400%). We noted a drop in neonatal unit admissions, immunisation clinic attendance and delivery of all vaccinations except measles. There was an immediate drop in clinic attendance for prevention of mother to child transmission of HIV (now stabilised) and an increase of 348% in childhood malnutrition clinic attendance. Maternal and neonatal deaths, immediate post-natal care and contraceptive provision remained within normal limits. <br>Conclusion: The response to COVID-19 in Uganda has negatively impacted maternal, child and neonatal health, with the biggest and longest lasting impact seen in complications of pregnancy, stillbirths and low-birthweight infants likely due to delayed care-seeking behaviour. The decline in vaccination clinic attendance has implications for all vaccine-preventable diseases, with a cohort of infants currently unprotected. Further consideration of the impacts of restricting movement and limiting access to preventative services must be undertaken in responding to future pandemics if key maternal and child health services are to be maintained.<br>
DOI: 10.24376/rd.sgul.14501541.v1
title: Indirect Effects of COVID-19 on Maternal, Neonatal, Child, Sexual and Reproductive Health Services in Kampala, Uganda

description: Background: COVID-19 has impacted global maternal, neonatal and child health outcomes. We hypothesised that the early, strict lockdown which severely limited the movements of individuals in Uganda will have impacted access to services.<br><br>Methods: An observational study, using routinely collected health data from Electronic Medical Records was carried out, utilising data from July 2019 to December 2020 in Kawempe district, Kampala. The mean and 95% confidence intervals were calculated pre-COVID (July 2019 – February 2020) and post-COVID (March-December 2020). The means were compared using t-tests, and the monthly totals analysed as to whether they lay within or outside the normal range, compared to the previous 9 months. <br>Results: Antenatal attendances decreased 96% in April 2020 and remain below pre-COVID levels. We found a rise in adverse pregnancy outcomes for Caesarean sections (5%), haemorrhages related to pregnancy (51%), stillbirths (31%) and low-birth-weight (162%) and premature infant births (400%). We noted a drop in neonatal unit admissions, immunisation clinic attendance and delivery of all vaccinations except measles. There was an immediate drop in clinic attendance for prevention of mother to child transmission of HIV (now stabilised) and an increase of 348% in childhood malnutrition clinic attendance. Maternal and neonatal deaths, immediate post-natal care and contraceptive provision remained within normal limits. <br>Conclusion: The response to COVID-19 in Uganda has negatively impacted maternal, child and neonatal health, with the biggest and longest lasting impact seen in complications of pregnancy, stillbirths and low-birthweight infants likely due to delayed care-seeking behaviour. The decline in vaccination clinic attendance has implications for all vaccine-preventable diseases, with a cohort of infants currently unprotected. Further consideration of the impacts of restricting movement and limiting access to preventative services must be undertaken in responding to future pandemics if key maternal and child health services are to be maintained.<br>
DOI: 10.6084/m9.figshare.14540148
title: Supplementary Material for: Efficiency and Clinical Outcomes of Moses Technology with Flexible Ureteroscopic Laser Lithotripsy for Treatment of Renal Calculus

description: <b><i>Objective:</i></b> The aim of the study was to compare the efficiency and clinical outcomes of Moses contact mode (MCM) and regular dusting mode (RDM) during flexible ureteroscopic lithotripsy (FURL) for treatment of renal calculus. <b><i>Methods:</i></b> This retrospective analysis examined 216 patients with renal calculus who underwent FURL with MCM or RDM between March 2015 and January 2020. Stone characteristics, including size, volume, and density, were collected. Laser parameters, including laser type, laser working time, laser pause time, and foot-pedal use, were automatically recorded by the lithotripter work panel. The percentages of laser working time and laser pause time, stone fragmentation efficiency (SFE; volume/laser working time), postoperative complications, including fever and acute renal failure (ARF), stone-free rate (SFR), and the need for auxiliary procedures were determined. <b><i>Results:</i></b> There were no significant differences in preoperative demographic and stone characteristics between the MCM group and the RDM group. The MCM group had a shorter laser working time (4.99 ± 1.06 vs. 5.94 ± 0.96 min, <i>p</i> &lt; 0.001) and a greater SFE (137.86 [163.78–114.38] versus 114.94 [132.06–101.34] mm<sup>3</sup>/min, <i>p</i> &lt; 0.001), which shortened the overall operative time (18.39 ± 5.13 vs. 21.17 ± 6.78 min, <i>p</i> = 0.001). There were no differences in postoperative complications, including fever and ARF, SFR (86.8 vs. 85.3%, <i>p</i> = 0.743), and auxiliary procedures between the 2 groups. <b><i>Conclusions:</i></b> Using Moses laser technology with FURL significantly reduced laser working time and increased SFE, which shortened overall operative time. Urologists should consider this new instrument for the clinical management of renal calculus.
DOI: 10.48370/ofd/xw1rre
title: Erysiphe ornata var. europaea (U. Braun) U. Braun S. Takam, 3669

description: Fungarium Mikromycetes
DOI: 10.34740/kaggle/dsv/2195562
title: LUFlow Network Intrusion Detection Data Set
DOI: 10.6084/m9.figshare.14540280
title: Supplementary Material for: MicroRNA-Mediated Drug Repurposing Unveiled Potential Candidate Drugs for Prolactinoma Treatment

description: <b><i>Introduction:</i></b> Prolactinomas, also called lactotroph adenomas, are the most encountered type of hormone-secreting pituitary neuroendocrine tumors in the clinic. The preferred first-line therapy is a medical treatment with dopamine agonists (DAs), mainly cabergoline, to reduce serum prolactin levels, tumor volume, and mass effect. However, in some cases, patients have displayed DA resistance with aggressive tumor behavior or are faced with recurrence after drug withdrawal. Also, currently used therapeutics have notorious side effects and impair the life quality of the patients. <b><i>Methods:</i></b> Since the amalgamation of clinical and laboratory data besides tumor histopathogenesis and transcriptional regulatory features of the tumor emerges to exhibit essential roles in the behavior and progression of prolactinomas; in this work, we integrated mRNA- and microRNA (miRNA)-level transcriptome data that exploit disease-specific signatures in addition to biological and pharmacological data to elucidate a rational prioritization of pathways and drugs in prolactinoma. <b><i>Results:</i></b> We identified 8 drug candidates through drug repurposing based on mRNA-miRNA-level data integration and evaluated their potential through in vitro assays in the MMQ cell line. Seven repurposed drugs including 5-fluorocytosine, nortriptyline, neratinib, puromycin, taxifolin, vorinostat, and zileuton were proposed as potential drug candidates for the treatment of prolactinoma. We further hypothesized possible mechanisms of drug action on MMQ cell viability through analyzing the PI3K/Akt signaling pathway and cell cycle arrest via flow cytometry and Western blotting. <b><i>Discussion:</i></b> We presented the transcriptomic landscape of prolactinoma through miRNA and mRNA-level data integration and proposed repurposed drug candidates based on this integration. We validated our findings through testing cell viability, cell cycle phases, and PI3K/Akt protein expressions. Effects of the drugs on cell cycle phases and inhibition of the PI3K/Akt pathway by all drugs gave us promising output for further studies using these drugs in the treatment of prolactinoma. This is the first study that reports miRNA-mediated repurposed drugs for prolactinoma treatment via in vitro experiments.
DOI: 10.6084/m9.figshare.14540280.v1
title: Supplementary Material for: MicroRNA-Mediated Drug Repurposing Unveiled Potential Candidate Drugs for Prolactinoma Treatment

description: <b><i>Introduction:</i></b> Prolactinomas, also called lactotroph adenomas, are the most encountered type of hormone-secreting pituitary neuroendocrine tumors in the clinic. The preferred first-line therapy is a medical treatment with dopamine agonists (DAs), mainly cabergoline, to reduce serum prolactin levels, tumor volume, and mass effect. However, in some cases, patients have displayed DA resistance with aggressive tumor behavior or are faced with recurrence after drug withdrawal. Also, currently used therapeutics have notorious side effects and impair the life quality of the patients. <b><i>Methods:</i></b> Since the amalgamation of clinical and laboratory data besides tumor histopathogenesis and transcriptional regulatory features of the tumor emerges to exhibit essential roles in the behavior and progression of prolactinomas; in this work, we integrated mRNA- and microRNA (miRNA)-level transcriptome data that exploit disease-specific signatures in addition to biological and pharmacological data to elucidate a rational prioritization of pathways and drugs in prolactinoma. <b><i>Results:</i></b> We identified 8 drug candidates through drug repurposing based on mRNA-miRNA-level data integration and evaluated their potential through in vitro assays in the MMQ cell line. Seven repurposed drugs including 5-fluorocytosine, nortriptyline, neratinib, puromycin, taxifolin, vorinostat, and zileuton were proposed as potential drug candidates for the treatment of prolactinoma. We further hypothesized possible mechanisms of drug action on MMQ cell viability through analyzing the PI3K/Akt signaling pathway and cell cycle arrest via flow cytometry and Western blotting. <b><i>Discussion:</i></b> We presented the transcriptomic landscape of prolactinoma through miRNA and mRNA-level data integration and proposed repurposed drug candidates based on this integration. We validated our findings through testing cell viability, cell cycle phases, and PI3K/Akt protein expressions. Effects of the drugs on cell cycle phases and inhibition of the PI3K/Akt pathway by all drugs gave us promising output for further studies using these drugs in the treatment of prolactinoma. This is the first study that reports miRNA-mediated repurposed drugs for prolactinoma treatment via in vitro experiments.
DOI: 10.5281/zenodo.4737212
title: Macapype validation, ucdavis_subject/sinai_subject.

description: T1/T2 image and brain_mask segmentation manuelle for Prime-DE, ucdavis_subject / sinai_subject.
DOI: 10.6084/m9.figshare.12219548
title: A customized bilevel optimization approach for solving large-scale truss design problems

description: Considerable academic research has been conducted on truss design optimization by standard metaheuristic methods; however, the generic nature of these methods becomes inefficient for problems with many decision variables. This may explain the simplicity of the relevant test problems in the academic literature in comparison with real structures. To address this challenge, this study advocates a customized optimization methodology which utilizes problem-specific knowledge. It improves upon a new bilevel truss optimization method to allow for an arbitrary trade-off between the stochastic upper level and the deterministic lower level search. Numerical simulations demonstrate that for large-scale truss design problems, the proposed method can find significantly lighter structures up to 300 times more quickly than the best existing metaheuristic methods. The remarkable findings of this study demonstrate the importance of using engineering knowledge and discourage future research on the development of purely metaheuristic methods for truss optimization.
DOI: 10.6084/m9.figshare.12219548.v1
title: A customized bilevel optimization approach for solving large-scale truss design problems

description: Considerable academic research has been conducted on truss design optimization by standard metaheuristic methods; however, the generic nature of these methods becomes inefficient for problems with many decision variables. This may explain the simplicity of the relevant test problems in the academic literature in comparison with real structures. To address this challenge, this study advocates a customized optimization methodology which utilizes problem-specific knowledge. It improves upon a new bilevel truss optimization method to allow for an arbitrary trade-off between the stochastic upper level and the deterministic lower level search. Numerical simulations demonstrate that for large-scale truss design problems, the proposed method can find significantly lighter structures up to 300 times more quickly than the best existing metaheuristic methods. The remarkable findings of this study demonstrate the importance of using engineering knowledge and discourage future research on the development of purely metaheuristic methods for truss optimization.
DOI: 10.5281/zenodo.4738532
title: Dataset related to article "COVID-19 Digestive System Involvement and Clinical Outcomes in a Large Academic Hospital in Milan, Italy"

description: This record contains raw data related to article “COVID-19 Digestive System Involvement and Clinical Outcomes in a Large Academic Hospital in Milan, Italy" Since February 2020, the COVID-19 pandemic has spread to Italy affecting more than 100,000 people. Several studies have reported a high prevalence of gastrointestinal (GI) symptoms, and investigated their potential association with clinical outcomes.<sup>1</sup> The timing, clinical significance, and possible impact on viral spread of GI symptoms presentation have not been fully elucidated. Elevation of liver function tests and other laboratory values has also been reported; however, their prognostic significance has not been clearly established.
DOI: 10.5281/zenodo.4738531
title: Dataset related to article "COVID-19 Digestive System Involvement and Clinical Outcomes in a Large Academic Hospital in Milan, Italy"

description: This record contains raw data related to article “COVID-19 Digestive System Involvement and Clinical Outcomes in a Large Academic Hospital in Milan, Italy" Since February 2020, the COVID-19 pandemic has spread to Italy affecting more than 100,000 people. Several studies have reported a high prevalence of gastrointestinal (GI) symptoms, and investigated their potential association with clinical outcomes.<sup>1</sup> The timing, clinical significance, and possible impact on viral spread of GI symptoms presentation have not been fully elucidated. Elevation of liver function tests and other laboratory values has also been reported; however, their prognostic significance has not been clearly established.
DOI: 10.6084/m9.figshare.14540355
title: Supplementary Material for: Neoadjuvant Systemic Chemotherapy in Sebaceous Gland Carcinoma of the Eyelid: A Retrospective Study

description: There are sparse data on neoadjuvant systemic chemotherapy (NACT) in eyelid sebaceous gland carcinoma (SGC). The aim of this study was to evaluate efficacy and outcomes with NACT in eyelid SGC. We retrospectively analyzed 8 patients who received platinum-based NACT. The median number of cycles per patient was 4 (range, 3–5). The mean percentage reduction of tumor diameter after NACT was 71% (range, 30–100%). Two patients had a radiological complete response (CR). After NACT, surgical treatment for residual tumor was performed in 5 cases. One patient had a pathological CR and is recurrence free for 11 years. After a mean follow-up period of 44.5 months (range, 9–109), tumor recurrence occurred in 4 cases. Among these 4 cases, 3 were rechallenged with the same regimen and all responded. Systemic NACT has a role in eyelid SGC, downstages the tumor, and allows less aggressive and organ-sparing surgeries, warranting a prospective study.
DOI: 10.17632/wyzc7g4pdy.1
title: leafmavis

description: This dataset includes ERP data, acoustic parameters of advertisement calls and phylogenetic data.
DOI: 10.17632/zhwkrc6k93.1
title: Hybrid Hydrogen Home Storage for Decentralized Energy Autonomy

description: To determine the cost minimal supply system and its operation for a self-sufficient building, a Mixed Integer Linear Program is developed within the modelling framework FINE. It uses the optimisation modelling language Pyomo and is available open source. The model represents decisions on the buildings’ energy system structure (technology selection), sizing (capacity of energy supply units) and operation for one representative year in a set of linear equations with continuous and binary variables. Sizing and operation for a self-sufficient supply has been optimized for the representative year with one-hour time-steps towards a goal function representing equivalent total annual costs.
DOI: 10.17632/s367bfmycp.1
title: Islamic Finance Modes in Islamic Banking Industry of Pakistan

description: Quarterly data of Islamic finance modes being used in the Islamic banking industry in Pakistan. The source of data is the Islamic banking bulletin quarterly issued by the Islamic banking department, state Bank of Pakistan.
DOI: 10.17632/d4x6gj3tb3.2
title: Floristic Composition of plant populations of Tаraxacum kok – saghyz

description: This database provides a floral composition of rare, endemic, valuable plants found in natural populations of the valuable plant Taraxacum kok - saghyz Rodin. 115 plant species belonging to 26 families grow in 3 studied populations ofTaraxacum kok - saghyz Rodin.
DOI: 10.17632/6d9stwzjhp.1
title: Data for: An exact algorithm for scheduling the tandem quay crane operations at the container terminal

description: Supplementary Raw Research Data
DOI: 10.17632/7xv5rzxgrh.1
title: Data for: Utilizing A Responsive Web Portal For Studying Disc Tracing Agreement in Retinal Images