cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.14326784
title: Fig 7 source data.xlsxCritical roles for the LINC01119-SOCS5 axis as a novel theranostic in triple-negative breast cancersThe LINC01119-SOCS5 axis as a critical theranostic in triple-negative breast cancer

description: The development of triple-negative breast cancer (TNBC) is critically regulated by certain tumor-microenvironment-associated cells called mesenchymal stem/stromal cells (MSCs), which we and others have shown promoted TNBC progression by activating pro-malignant signaling in neighboring cancer cells. Characterization of these cascades will better our understanding of TNBC biology, and stands to bring about therapeutics that can eliminate the morbidity and mortality associated with advanced disease. Here, we focused on the emerging class of non-coding RNAs called long non-coding RNAs or lncRNAs, and utilized a MSC-supported TNBC progression model to identify specific family members of functional relevance to TNBC pathogenesis. Indeed, although some have been described to play functional roles in TNBC, activities for lncRNAs as mediators of tumor-microenvironment-driven TNBC development remain to be fully explored. We report that MSCs stimulated robust expression of LINC01119 in TNBC cells, which in turn induced suppressor of cytokine signaling 5 (SOCS5), leading to accelerated cancer cell growth and tumorigenesis. We show that LINC01119 and SOCS5 exhibited tight correlation across multiple breast cancer gene sets and that they were highly enriched in TNBC patient cohorts. Importantly, we present evidence that the LINC01119-SOCS5 axis served as a powerful prognostic indicator of adverse outcome in TNBC patients, and we demonstrate that its repression severely impaired cancer cell growth. Altogether, our findings identify LINC01119 as a major driver of TNBC development, and delineate critical non-coding RNA theranostics of potential translational utility in the management of advanced TNBC, a class of tumors in most need of effective and targeted therapy.
DOI: 10.6084/m9.figshare.14326784.v1
title: Fig 7 source data.xlsxCritical roles for the LINC01119-SOCS5 axis as a novel theranostic in triple-negative breast cancersThe LINC01119-SOCS5 axis as a critical theranostic in triple-negative breast cancer

description: The development of triple-negative breast cancer (TNBC) is critically regulated by certain tumor-microenvironment-associated cells called mesenchymal stem/stromal cells (MSCs), which we and others have shown promoted TNBC progression by activating pro-malignant signaling in neighboring cancer cells. Characterization of these cascades will better our understanding of TNBC biology, and stands to bring about therapeutics that can eliminate the morbidity and mortality associated with advanced disease. Here, we focused on the emerging class of non-coding RNAs called long non-coding RNAs or lncRNAs, and utilized a MSC-supported TNBC progression model to identify specific family members of functional relevance to TNBC pathogenesis. Indeed, although some have been described to play functional roles in TNBC, activities for lncRNAs as mediators of tumor-microenvironment-driven TNBC development remain to be fully explored. We report that MSCs stimulated robust expression of LINC01119 in TNBC cells, which in turn induced suppressor of cytokine signaling 5 (SOCS5), leading to accelerated cancer cell growth and tumorigenesis. We show that LINC01119 and SOCS5 exhibited tight correlation across multiple breast cancer gene sets and that they were highly enriched in TNBC patient cohorts. Importantly, we present evidence that the LINC01119-SOCS5 axis served as a powerful prognostic indicator of adverse outcome in TNBC patients, and we demonstrate that its repression severely impaired cancer cell growth. Altogether, our findings identify LINC01119 as a major driver of TNBC development, and delineate critical non-coding RNA theranostics of potential translational utility in the management of advanced TNBC, a class of tumors in most need of effective and targeted therapy.
DOI: 10.6084/m9.figshare.14327029
title: The use of neem oil and chitosan during pre-harvest and in the post-harvest quality of the ‘Paluma’ guava

description: ABSTRACT Guava is a fruit that is susceptible to attack by pests and diseases both pre- and post-harvest, making it important to employ techniques which maintain its quality, such as the use of neem-based products and chitosan together with cold storage. The aim of the present study was to evaluate the use of neem oil and chitosan during pre-harvest and in the post-harvest quality of the ‘Paluma’ guava. The experiment was conducted on a property in the district of Mamanguape, Paraíba. Eighteen guava trees were selected, and the following treatments were applied: a control; neem oil 0.5%; neem oil 1%; chitosan 0.5%; chitosan 1%; neem oil 0.5% + chitosan 0.5%; neem oil 0.5% + chitosan 1%; neem oil 1% + chitosan 0.5% and neem oil 1% + chitosan 1%. When at the commercially mature stage, the fruit was harvested, packed in a harvesting crate and transported to the Post-Harvest Physiology Laboratory (CCHSA/UFPB). The fruit was selected, stored at 24 ± 1 °C and evaluated for 10 days, and then stored at 10 ± 1 °C and evaluated for 20 days, followed by physical, chemical and enzymatic analysis. Coating with neem oil (0.5%) + chitosan (1%) during pre-harvest proved to be effective in preserving and prolonging the quality of the ‘Paluma’ guava during storage for 8 days at 24 ± 1 °C, and 16 days at 10 ± 1 °C.
DOI: 10.6084/m9.figshare.14327029.v1
title: The use of neem oil and chitosan during pre-harvest and in the post-harvest quality of the ‘Paluma’ guava

description: ABSTRACT Guava is a fruit that is susceptible to attack by pests and diseases both pre- and post-harvest, making it important to employ techniques which maintain its quality, such as the use of neem-based products and chitosan together with cold storage. The aim of the present study was to evaluate the use of neem oil and chitosan during pre-harvest and in the post-harvest quality of the ‘Paluma’ guava. The experiment was conducted on a property in the district of Mamanguape, Paraíba. Eighteen guava trees were selected, and the following treatments were applied: a control; neem oil 0.5%; neem oil 1%; chitosan 0.5%; chitosan 1%; neem oil 0.5% + chitosan 0.5%; neem oil 0.5% + chitosan 1%; neem oil 1% + chitosan 0.5% and neem oil 1% + chitosan 1%. When at the commercially mature stage, the fruit was harvested, packed in a harvesting crate and transported to the Post-Harvest Physiology Laboratory (CCHSA/UFPB). The fruit was selected, stored at 24 ± 1 °C and evaluated for 10 days, and then stored at 10 ± 1 °C and evaluated for 20 days, followed by physical, chemical and enzymatic analysis. Coating with neem oil (0.5%) + chitosan (1%) during pre-harvest proved to be effective in preserving and prolonging the quality of the ‘Paluma’ guava during storage for 8 days at 24 ± 1 °C, and 16 days at 10 ± 1 °C.
DOI: 10.6084/m9.figshare.14326772
title: Supplementary Fig 6 source data.xlsxCritical roles for the LINC01119-SOCS5 axis as a novel theranostic in triple-negative breast cancersThe LINC01119-SOCS5 axis as a critical theranostic in triple-negative breast cancer

description: Supplementary Fig 6 source datThe development of triple-negative breast cancer (TNBC) is critically regulated by certain tumor-microenvironment-associated cells called mesenchymal stem/stromal cells (MSCs), which we and others have shown promoted TNBC progression by activating pro-malignant signaling in neighboring cancer cells. Characterization of these cascades will better our understanding of TNBC biology, and stands to bring about therapeutics that can eliminate the morbidity and mortality associated with advanced disease. Here, we focused on the emerging class of non-coding RNAs called long non-coding RNAs or lncRNAs, and utilized a MSC-supported TNBC progression model to identify specific family members of functional relevance to TNBC pathogenesis. Indeed, although some have been described to play functional roles in TNBC, activities for lncRNAs as mediators of tumor-microenvironment-driven TNBC development remain to be fully explored. We report that MSCs stimulated robust expression of LINC01119 in TNBC cells, which in turn induced suppressor of cytokine signaling 5 (SOCS5), leading to accelerated cancer cell growth and tumorigenesis. We show that LINC01119 and SOCS5 exhibited tight correlation across multiple breast cancer gene sets and that they were highly enriched in TNBC patient cohorts. Importantly, we present evidence that the LINC01119-SOCS5 axis served as a powerful prognostic indicator of adverse outcome in TNBC patients, and we demonstrate that its repression severely impaired cancer cell growth. Altogether, our findings identify LINC01119 as a major driver of TNBC development, and delineate critical non-coding RNA theranostics of potential translational utility in the management of advanced TNBC, a class of tumors in most need of effective and targeted therapy.
DOI: 10.6084/m9.figshare.14327056
title: Genetic tolerance to low temperatures in irrigated rice

description: ABSTRACT The aim of this study was to characterise genetic variability to low-temperature tolerance in the emergence stage of irrigated-rice genotypes under controlled and field conditions. Thirty-seven genotypes were evaluated, interspersed with controls of different levels of low-temperature tolerance. The design used was of randomised blocks with three replications. The genotypes were submitted to germination and emergence in controlled-temperature trials at 13 ºC (Trial I) and 17 ºC (Trial II), and in field environments with no cover (Trial III) and with a cover of polyethylene (Trial IV), where the soil temperature was monitored. The evaluations were carried out daily by counting the emerged seedlings and later inferring the speed of emergence index (SEI). The results showed (experiment I to IV) that the SEI varied from 0.61 to 4.23, increasing by 0.4259 for each 1 ºC increase in soil temperature. The genotypes Ostiglia, Diamante, Baldo, Carnaroli, Selenio, Loto e Amarelo, of subspecies japonica, and Ringo Miara-AC and Arelate, of subspecies indica, are promising sources of genetic tolerance to low temperature. Temperatures of less than 17 ºC reduce the number of emerged seedlings and delay development in each of the rice genotypes under test, with a greater or lesser negative effect on the initial plant stand per unit area.
DOI: 10.6084/m9.figshare.14327056.v1
title: Genetic tolerance to low temperatures in irrigated rice

description: ABSTRACT The aim of this study was to characterise genetic variability to low-temperature tolerance in the emergence stage of irrigated-rice genotypes under controlled and field conditions. Thirty-seven genotypes were evaluated, interspersed with controls of different levels of low-temperature tolerance. The design used was of randomised blocks with three replications. The genotypes were submitted to germination and emergence in controlled-temperature trials at 13 ºC (Trial I) and 17 ºC (Trial II), and in field environments with no cover (Trial III) and with a cover of polyethylene (Trial IV), where the soil temperature was monitored. The evaluations were carried out daily by counting the emerged seedlings and later inferring the speed of emergence index (SEI). The results showed (experiment I to IV) that the SEI varied from 0.61 to 4.23, increasing by 0.4259 for each 1 ºC increase in soil temperature. The genotypes Ostiglia, Diamante, Baldo, Carnaroli, Selenio, Loto e Amarelo, of subspecies japonica, and Ringo Miara-AC and Arelate, of subspecies indica, are promising sources of genetic tolerance to low temperature. Temperatures of less than 17 ºC reduce the number of emerged seedlings and delay development in each of the rice genotypes under test, with a greater or lesser negative effect on the initial plant stand per unit area.
DOI: 10.6084/m9.figshare.14327040
title: Salt tolerance during the seedling production stage of Catharanthus roseus, Tagetes patula and Celosia argentea

description: ABSTRACT The guarantee of water supply for irrigated agriculture in the semi-arid region must necessarily involve the use of lower quality water, such as brackish water. The objective of the present work was to evaluate the tolerance to salinity of the ornamental species Catharanthus roseus, Tagetes patula and Celosia argentea, using different methods. The experiment was conducted in a randomized block, arranged in a 10 x 3 factorial scheme, corresponding to 10 saline concentrations of irrigation water (ECw 0.5; 1.0; 1.5; 2.0; 2.5; 3.0; 3.5; 4.0; 5.0 and 6.0 dS m-1) and 3 ornamental species. Four salinity tolerance assessment methods were tested, using relative values or percentages of reduction in quantitative and qualitative analyses. The different methods show the highest sensitivity to salinity of C. roseus, in the seedling production stage, compared to T. patula and C. argentea species. The methods of threshold salinity and ORN index led to similar results in terms of classification of salt tolerance, with C. roseus classified as sensitive and T. patula and C. argentea as moderately sensitive. The method of Fageria (1985) allowed good separation of the species, with tolerance limits of 1.5, 2.5 and 3.5 dS m-1, respectively for C. roseus, T. patula and C. argentea. It is obvious from the comparison with literature data that the seedling production stage is more sensitive to salt stress, and it is necessary to carry out new studies aimed at attenuating the effects of stress at this stage, through the use of management techniques.
DOI: 10.25318/1810003101-fra
title: Indice des prix des produits industriels, pour certains produits, par régions, mensuel, inactif

description: Indice des prix des produits industriels, pour certains produits, par régions, (IPPI) selon le Système de classification des produits de l’Amérique du Nord (SCPAN). Les données mensuelles sont disponibles à partir de janvier 1971. Le tableau présente les données de la période de référence la plus récente et des quatre dernières périodes. La période de base de l’indice est (2010=100).
DOI: 10.6084/m9.figshare.14327064
title: Principal component and cluster analyses to evaluate production and milk quality traits

description: ABSTRACT Using multivariate analyses, this study attempted to identify important traits explaining the relationship between milk production and quality produced by Holstein cows. Monthly milk records from three commercial dairy farms located in the Agreste region of Pernambuco, Brazil, collected in the period from 2007 to 2017, were used. A total of 5,872 observations regarding milk production, milk components and somatic cell score (SCS) were analyzed using principal component analysis (PCA) and cluster analysis. According to the former analysis, the first three principal components explained 79.69% of the total variation. Total solids content contributed 29.66% of the variation in the first principal component, while lactose content contributed 49.43% of the variation in the second principal component. According to the latter analysis, three clusters differed for all characteristics (p&lt;0.001) and cluster 2 concentrated 43.15% (2,534) of the information with lower SCS and higher lactose content and milk production. Total solids, lactose and fat were considered the most representative traits explaining the variability of the data set. The multivariate techniques used in this study proved useful in obtaining effective characteristics, with three factors considered important in explaining the relationship between Holstein cows’ milk production and quality.
DOI: 10.6084/m9.figshare.14327040.v1
title: Salt tolerance during the seedling production stage of Catharanthus roseus, Tagetes patula and Celosia argentea

description: ABSTRACT The guarantee of water supply for irrigated agriculture in the semi-arid region must necessarily involve the use of lower quality water, such as brackish water. The objective of the present work was to evaluate the tolerance to salinity of the ornamental species Catharanthus roseus, Tagetes patula and Celosia argentea, using different methods. The experiment was conducted in a randomized block, arranged in a 10 x 3 factorial scheme, corresponding to 10 saline concentrations of irrigation water (ECw 0.5; 1.0; 1.5; 2.0; 2.5; 3.0; 3.5; 4.0; 5.0 and 6.0 dS m-1) and 3 ornamental species. Four salinity tolerance assessment methods were tested, using relative values or percentages of reduction in quantitative and qualitative analyses. The different methods show the highest sensitivity to salinity of C. roseus, in the seedling production stage, compared to T. patula and C. argentea species. The methods of threshold salinity and ORN index led to similar results in terms of classification of salt tolerance, with C. roseus classified as sensitive and T. patula and C. argentea as moderately sensitive. The method of Fageria (1985) allowed good separation of the species, with tolerance limits of 1.5, 2.5 and 3.5 dS m-1, respectively for C. roseus, T. patula and C. argentea. It is obvious from the comparison with literature data that the seedling production stage is more sensitive to salt stress, and it is necessary to carry out new studies aimed at attenuating the effects of stress at this stage, through the use of management techniques.
DOI: 10.6084/m9.figshare.14326772.v1
title: Supplementary Fig 6 source data.xlsxCritical roles for the LINC01119-SOCS5 axis as a novel theranostic in triple-negative breast cancersThe LINC01119-SOCS5 axis as a critical theranostic in triple-negative breast cancer

description: Supplementary Fig 6 source datThe development of triple-negative breast cancer (TNBC) is critically regulated by certain tumor-microenvironment-associated cells called mesenchymal stem/stromal cells (MSCs), which we and others have shown promoted TNBC progression by activating pro-malignant signaling in neighboring cancer cells. Characterization of these cascades will better our understanding of TNBC biology, and stands to bring about therapeutics that can eliminate the morbidity and mortality associated with advanced disease. Here, we focused on the emerging class of non-coding RNAs called long non-coding RNAs or lncRNAs, and utilized a MSC-supported TNBC progression model to identify specific family members of functional relevance to TNBC pathogenesis. Indeed, although some have been described to play functional roles in TNBC, activities for lncRNAs as mediators of tumor-microenvironment-driven TNBC development remain to be fully explored. We report that MSCs stimulated robust expression of LINC01119 in TNBC cells, which in turn induced suppressor of cytokine signaling 5 (SOCS5), leading to accelerated cancer cell growth and tumorigenesis. We show that LINC01119 and SOCS5 exhibited tight correlation across multiple breast cancer gene sets and that they were highly enriched in TNBC patient cohorts. Importantly, we present evidence that the LINC01119-SOCS5 axis served as a powerful prognostic indicator of adverse outcome in TNBC patients, and we demonstrate that its repression severely impaired cancer cell growth. Altogether, our findings identify LINC01119 as a major driver of TNBC development, and delineate critical non-coding RNA theranostics of potential translational utility in the management of advanced TNBC, a class of tumors in most need of effective and targeted therapy.
DOI: 10.6084/m9.figshare.14327074.v1
title: Acute toxicity of non-ionized ammonia on tambacu (Colossoma macropomum x Piaractus mesopotamicus)

description: ABSTRACT Ammonia is a toxic compound to aquatic organisms and at high concentrations in water, it can cause various changes in the animal. Therefore, it becomes important to determine the tolerance of farmed aquatic animals for that substance. Thus, the aim of this study was to determine the mean lethal concentration (LC50-96 h) of un-ionized ammonia (NH3) in tambacu fingerlings (Colossoma macropomum x Piaractus mesopotamicus) in acute toxicity test. The fingerlings were exposed to ammonia at concentrations of: 0.09 (control); 0.54; 1.23; 2.52; 3.44 and 3.66 mg L-1 NH3, which were obtained from the application of NH4Cl. The test lasted 96 hours and mortalities were recorded over that period. The LC50 was determined by the Trimmed Spearman Karber statistical method. The LC50-96 h of non-ionized ammonia (NH3) for fingerlings of the tambacu hybrid was 1.63 mg L-1.
DOI: 10.6084/m9.figshare.14327076
title: Effect of climate and geographical conditions on the occurrence of cashew gummosis in the northeast of Brazil

description: ABSTRACT Cashew gummosis is one of the main diseases of the cashew in the semi-arid region of the northeast and is characterised by a decline in the plants and a reduction in stand. Lasiodiplodia theobromae, the causal agent, is an endophytic fungus that eventually takes on pathogenic characteristics; however, the environmental conditions that cause this change in behaviour are still unknown. It is assumed that stress in the host caused by environmental changes stimulate pathogenicity. The aim of this study was to define the relationship between climate and geographical factors and the occurrence of gummosis. Rainfall data, maximum and minimum temperature, thermal amplitude, and the altitude of 14 micro-regions in the northeast were compared and classified into five frequencies of disease occurrence: 0 (no occurrence), 1 (rare occurrence), 2 (frequent occurrence), 3 ( generalised occurrence) and 4 (generalised high-severity occurrence). The data were submitted to the Doornik-Hansen test for multivariate normality, and principal component analysis was carried out using the correlation matrix between the climate and geographical variables and occurrence of the disease. Areas of disease severity were correlated (Pearson’s correlation). Only thermal amplitude, altitude and latitude were associated with the different areas of gummosis occurrence. The districts of Buíque, in the state of Pernambuco, and São Raimundo Nonato, Canto do Buriti and Pio IX, in Piauí, with the highest incidence of the disease, had the highest values for thermal amplitude, altitude and latitude. Whereas the districts of Pacajus and Beberibe had a lower occurrence of gummosis, with lower values for thermal amplitude, altitude and latitude.