cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.30590175.v1
title: Modified heated dynamics and deep mutational scanning enhance anti-CXCR2 antibody affinity

description: Colorectal cancer (CRC) is a leading global malignancy, with many stage IV cases requiring surgery and chemotherapy. However, chemoresistance limits treatment efficacy. Targeting resistance pathways such as CXCR2 with therapeutic antibodies offers a promising solution. This study harnessed deep mutational scanning guided by modified heated coarse-grained molecular dynamics (CGMD) simulations, to enhance the binding affinity of the HY29-1 antibody toward CXCR2. The structural stability and intermolecular binding of the variable heavy (vH) and light (vL) chains of the HY29-1 antibody fragment (Fv-HY29-1) alone and complexed with CXCR2 were assessed using modified heated CGMD simulations under thermal stress conditions. Using a modified heated CGMD protocol, the Fv-HY29-1 antibody fragment, modeled <i>via</i> ClusPro (C7) exhibited remarkable conformational stability, maintaining complete (100%) complexation with CXCR2 over a 70 ns simulation. Meanwhile, a benchmark model of the established Fv-Fab14–canine parvovirus capsid complex retained 100% stability under similar conditions. Extended deep mutational scanning over a 1000 ns trajectory pinpointed critical framework residues in the vL chain (A43, L47, and F98) as key determinants of paratope–epitope binding. Rational substitutions (A43P, L47V, F98W) significantly enhanced binding affinity, improving from −36.02 kcal/mol to −94.09 kcal/mol, approximately two-fold increase in binding strength. This marked affinity gain translated into strengthened CXCR2 engagement, highlighting the promise of structure-guided antibody engineering in optimizing therapeutic interactions. This study demonstrated that a 1 μs modified heated simulation with coarse-grained models and deep mutational scanning enables cost-effective optimization of antibody binding affinity and will guide future design of high-affinity antibodies across diverse antigen targets. The Fv-HY29-1-CXCR2 complex remained 100% stable in modified heated MD simulations.The established Fv-Fab14–canine parvovirus capsid complex model retained 100% stability under similar conditions.Deep mutational scanning through 1000 ns simulation pinpointed crucial residues for stronger antibody-CXCR2 interaction.Mutations in the vL chain (A43P, L47V, F98W) improved binding affinity by approximately two-fold, enhancing CXCR2 engagement. The Fv-HY29-1-CXCR2 complex remained 100% stable in modified heated MD simulations. The established Fv-Fab14–canine parvovirus capsid complex model retained 100% stability under similar conditions. Deep mutational scanning through 1000 ns simulation pinpointed crucial residues for stronger antibody-CXCR2 interaction. Mutations in the vL chain (A43P, L47V, F98W) improved binding affinity by approximately two-fold, enhancing CXCR2 engagement.
DOI: 10.25549/inscriptifact-ouc110616358
title: Persepolis Fortification Elamite Tablet 0284, PF-NN 0284

description: [Text Description:] Administrative text with seal ❧ [Text or Publication Number Note:] PF-NN 0284 ❧ [Excavation Description:] Found during Oriental Institute's excavations in Spring, 1933, near the northeastern corner of the stone platform of Persepolis, in two small rooms of a bastion in the fortification wall ❧ [Medium:] Clay ❧ [Script Note:] Non-Alphabetic Cuneiform ❧ [Physical Object Description:] Clay tablet with cuneiform text. Seal impression (?) on left edge. ❧ [Physical Object Note:] Chipping on reverse. Minor cracks throughout tablet.
DOI: 10.15468/dl.xujk9h
title: Occurrence Download

description: A dataset containing 53215 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Geometry POLYGON((-134.18377 20.21308,-57.81623 20.21308,-57.81623 50.78692,-134.18377 50.78692,-134.18377 20.21308))",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 "TaxonKey is Terrapene carolina carolina"
 ]
}

 The dataset includes 53215 records from 29 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0026054-260208012135463/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.25934/pr00011742
title: Bellmunt Risk Score in metastatic hormone-sensitive prostate cancer (mHSPC)

description: Prostate cancer is one of the most common cancers in men around the world. Some men are diagnosed with prostate cancer that has already spread to other parts of the body (metastatic prostate cancer). In the early stages, this type of cancer often responds to hormone therapy, which lowers or blocks the male hormones that help the cancer grow. This stage is called metastatic hormone-sensitive prostate cancer (mHSPC). Over time, the disease may become more difficult to treat and stop responding to hormone therapy, becoming metastatic castration-resistant prostate cancer (mCRPC).

Doctors need better ways to estimate how long someone with prostate cancer might live or how aggressive their cancer might become. One tool that helps with this is the Bellmunt Risk Score (BRS). This score uses three common clinical measures: (1) how well a person can carry out daily activities, measured by the Eastern Cooperative Oncology Group Performance Status (ECOG PS); (2) the concentration of the oxygen-carrying molecule within the blood, known as hemoglobin; and (3) whether the cancer has spread to the liver (called liver metastases). We have already shown that the BRS is a useful tool for predicting survival in men with mCRPC.

In this project, we will investigate whether the same tool can also help predict outcomes in men at an earlier stage—those with mHSPC. To do this, we will analyze individual participant data from three large clinical trials: ARASENS, TITAN, and LATITUDE. These trials include men with mHSPC and contain the same clinical information used in the BRS.

Our goal is to see if the BRS can help doctors and patients with mHSPC understand their likely outcomes. If successful, this simple tool could be used to guide treatment decisions, provide clearer expectations, and improve communication between doctors and patients.

We will carry out statistical analyses to test how well the BRS predicts outcomes in this earlier stage of disease. We will also explore whether the score works equally well across different trials and patient groups. This research will help determine whether a single, easy-to-use score can be widely used across the full course of advanced prostate cancer.
DOI: 10.60712/si-id246206.1
title: StrainInfo SI-ID 246206.1

description: StrainInfo dataset 246206 about a strain of Penicillium viridicatum. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id246282.1
title: StrainInfo SI-ID 246282.1

description: StrainInfo dataset 246282 about a strain of Aspergillus fumigatus. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id246283.1
title: StrainInfo SI-ID 246283.1

description: StrainInfo dataset 246283 about a strain of Aspergillus ochraceus. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id246284.1
title: StrainInfo SI-ID 246284.1

description: StrainInfo dataset 246284 about a strain of Aspergillus tamarii. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.15468/dl.g53fd4
title: Occurrence Download

description: A dataset containing 30025 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Nymphoides peltata (S.G.Gmel.) Kuntze"
 ]
}

 The dataset includes 30025 records from 446 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0160133-220831081235567/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.60712/si-id246285.1
title: StrainInfo SI-ID 246285.1

description: StrainInfo dataset 246285 about a strain of Aspergillus niger. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id246375.1
title: StrainInfo SI-ID 246375.1

description: StrainInfo dataset 246375 about a strain of Penicillium camemberti. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id246376.1
title: StrainInfo SI-ID 246376.1

description: StrainInfo dataset 246376 about a strain of Penicillium coprophilum. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id246377.1
title: StrainInfo SI-ID 246377.1

description: StrainInfo dataset 246377 about a strain of Monascus pilosus. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id246207.1
title: StrainInfo SI-ID 246207.1

description: StrainInfo dataset 246207 about a strain of Monascus ruber. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id246208.1
title: StrainInfo SI-ID 246208.1

description: StrainInfo dataset 246208 about a strain of Aspergillus ruber. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id246209.1
title: StrainInfo SI-ID 246209.1

description: StrainInfo dataset 246209 about a strain of Aspergillus niger. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.15468/dl.967m74
title: Occurrence Download

description: A dataset containing 722043 species occurrences available in GBIF matching the query:
{
 "and" : [
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 "TaxonKey is Caudata",
 "Year 1600-2001"
 ]
}

 The dataset includes 722043 records from 362 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0080974-210914110416597/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.pqbjpe
title: Occurrence Download

description: A dataset containing 383 species occurrences available in GBIF matching the query:
{
 "and" : [
 {
 "or" : [
 "Country is United States of America",
 "Country is Mexico"
 ]
 },
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 "TaxonKey is Ludwigia linearis Walter"
 ]
}

 The dataset includes 383 records from 31 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0143103-210914110416597/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.60712/si-id246286.1
title: StrainInfo SI-ID 246286.1

description: StrainInfo dataset 246286 about a strain of Aspergillus wentii. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id246287.1
title: StrainInfo SI-ID 246287.1

description: StrainInfo dataset 246287 about a strain of Penicillium verrucosum. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id246288.1
title: StrainInfo SI-ID 246288.1

description: StrainInfo dataset 246288 about a strain of Aspergillus chevalieri. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id246289.1
title: StrainInfo SI-ID 246289.1

description: StrainInfo dataset 246289 about a strain of Aspergillus candidus. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.15468/dl.y7m4uz
title: Occurrence Download

description: A dataset containing 353 species occurrences available in GBIF matching the query:
{
 "and" : [
 {
 "or" : [
 "Country is United States of America",
 "Country is Mexico"
 ]
 },
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 "TaxonKey is Lobelia feayana A.Gray"
 ]
}

 The dataset includes 353 records from 16 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0142727-210914110416597/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.60712/si-id246378.1
title: StrainInfo SI-ID 246378.1

description: StrainInfo dataset 246378 about a strain of Monascus pilosus. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id246379.1
title: StrainInfo SI-ID 246379.1

description: StrainInfo dataset 246379 about a strain of Beauveria bassiana. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.15468/dl.ym6mf6
title: Occurrence Download

description: A dataset containing 7182 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Pistacia chinensis Bunge"
 ]
}

 The dataset includes 7182 records from 143 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0082380-240506114902167/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.60712/si-id246380.1
title: StrainInfo SI-ID 246380.1

description: StrainInfo dataset 246380 about a strain of Aspergillus flavus. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id246381.1
title: StrainInfo SI-ID 246381.1

description: StrainInfo dataset 246381 about a strain of Pichia membranifaciens. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id246210.1
title: StrainInfo SI-ID 246210.1

description: StrainInfo dataset 246210 about a strain of Alternaria alternata. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id246211.1
title: StrainInfo SI-ID 246211.1

description: StrainInfo dataset 246211 about a strain of Penicillium chrysogenum. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id246212.1
title: StrainInfo SI-ID 246212.1

description: StrainInfo dataset 246212 about a strain of Aspergillus brunneus. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id246213.1
title: StrainInfo SI-ID 246213.1

description: StrainInfo dataset 246213 about a strain of Aspergillus amstelodami. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id246290.1
title: StrainInfo SI-ID 246290.1

description: StrainInfo dataset 246290 about a strain of Wallemia sebi. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id246291.1
title: StrainInfo SI-ID 246291.1

description: StrainInfo dataset 246291 about a strain of Aspergillus niger. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.15468/dl.mh5c4d
title: Occurrence Download

description: A dataset containing 22545 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Pittosporum undulatum Vent."
 ]
}

 The dataset includes 22545 records from 188 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0012373-200613084148143/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.60712/si-id246292.1
title: StrainInfo SI-ID 246292.1

description: StrainInfo dataset 246292 about a strain of Aspergillus flavus. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id246293.1
title: StrainInfo SI-ID 246293.1

description: StrainInfo dataset 246293 about a strain of Aspergillus ruber. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id246382.1
title: StrainInfo SI-ID 246382.1

description: StrainInfo dataset 246382 about a strain of Penicillium nalgiovense. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id246383.1
title: StrainInfo SI-ID 246383.1

description: StrainInfo dataset 246383 about a strain of Aspergillus flavus. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id246384.1
title: StrainInfo SI-ID 246384.1

description: StrainInfo dataset 246384 about a strain of Penicillium citrinum. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id246385.1
title: StrainInfo SI-ID 246385.1

description: StrainInfo dataset 246385 about a strain of Penicillium commune. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.15468/dl.nqh7x3
title: Occurrence Download

description: A dataset containing 41 species occurrences available in GBIF matching the query:
{
 "and" : [
 {
 "or" : [
 "Country is United States of America",
 "Country is Mexico"
 ]
 },
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 "TaxonKey is Lobelia flaccidifolia Small"
 ]
}

 The dataset includes 41 records from 11 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0142738-210914110416597/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.60712/si-id246214.1
title: StrainInfo SI-ID 246214.1

description: StrainInfo dataset 246214 about a strain of Penicillium thomii. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.15468/dl.sjbs2r
title: Occurrence Download

description: A dataset containing 74 species occurrences available in GBIF matching the query:
{
 "and" : [
 {
 "or" : [
 "Country is United States of America",
 "Country is Mexico"
 ]
 },
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 "TaxonKey is Eurybia paludosa (Aiton) G.L.Nesom"
 ]
}

 The dataset includes 74 records from 17 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0143679-210914110416597/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.60712/si-id246215.1
title: StrainInfo SI-ID 246215.1

description: StrainInfo dataset 246215 about a strain of Penicillium corynephorum. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id246216.1
title: StrainInfo SI-ID 246216.1

description: StrainInfo dataset 246216 about a strain of Penicillium janthinellum. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id246217.1
title: StrainInfo SI-ID 246217.1

description: StrainInfo dataset 246217 about a strain of Papiliotrema laurentii. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.