cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.5517/ccrkxw2
title: CCDC 702425: Experimental Crystal Structure Determination

description: Related Article: J.Fierro-Arias, D.Morales-Morales, S.Hernandez-Ortega|2008|Acta Crystallogr.,Sect.E:Struct.Rep.Online|64|m1196|doi:10.1107/S1600536808026718
DOI: 10.5517/ccrky6f
title: CCDC 702435: Experimental Crystal Structure Determination

description: Related Article: Xiao-Feng Wang, Jin-Feng Wang, Xiao-Yang Liu|2008|Acta Crystallogr.,Sect.E:Struct.Rep.Online|64|m1220|doi:10.1107/S1600536808027281
DOI: 10.5517/ccrl74p
title: CCDC 702712: Experimental Crystal Structure Determination

description: Related Article: A.Gille, M.Schurmann, H.Preut, M.Hiersemann|2008|Acta Crystallogr.,Sect.E:Struct.Rep.Online|64|o1835|doi:10.1107/S1600536808026998
DOI: 10.5517/ccrkxnv
title: CCDC 702418: Experimental Crystal Structure Determination

description: Related Article: R.Reisi, M.Misran, K.M.Lo, S.W.Ng|2008|Acta Crystallogr.,Sect.E:Struct.Rep.Online|64|m1187|doi:10.1107/S1600536808023799
DOI: 10.5517/ccrl1t5
title: CCDC 702547: Experimental Crystal Structure Determination

description: Related Article: S.Mansor, W.A.Yehye, A.Ariffin, N.A.Rahman, S.W.Ng|2008|Acta Crystallogr.,Sect.E:Struct.Rep.Online|64|o1799|doi:10.1107/S1600536808026202
DOI: 10.5517/ccrl1v6
title: CCDC 702548: Experimental Crystal Structure Determination

description: Related Article: M.Z.A.Fairuz, Z.Aiyub, Z.Abdullah, S.W.Ng|2008|Acta Crystallogr.,Sect.E:Struct.Rep.Online|64|o1800|doi:10.1107/S1600536808026317
DOI: 10.5517/ccrl70k
title: CCDC 702708: Experimental Crystal Structure Determination

description: Related Article: Hua-Rong Huang, Yan-Xiong Fang, Zhi-Yun Du, Kun Zhang, Yong-Cheng Lin|2008|Acta Crystallogr.,Sect.E:Struct.Rep.Online|64|o1801|doi:10.1107/S1600536808026391
DOI: 10.5517/ccrl1w7
title: CCDC 702549: Experimental Crystal Structure Determination

description: Related Article: C.Kitamura, N.Akamatsu, A.Yoneda, T.Kawase|2008|Acta Crystallogr.,Sect.E:Struct.Rep.Online|64|o1802|doi:10.1107/S1600536808026500
DOI: 10.5517/ccrl1x8
title: CCDC 702550: Experimental Crystal Structure Determination

description: Related Article: H.-K.Fun, V.Mirkhani, A.R.Vartooni|2008|Acta Crystallogr.,Sect.E:Struct.Rep.Online|64|o1803|doi:10.1107/S1600536808026652
DOI: 10.5517/ccrbr4y
title: CCDC 695520: Experimental Crystal Structure Determination

description: Related Article: P.Hemalatha, V.Veeravazhuthi|2008|Acta Crystallogr.,Sect.E:Struct.Rep.Online|64|o1805|doi:10.1107/S1600536808026512
DOI: 10.5517/ccrl1y9
title: CCDC 702551: Experimental Crystal Structure Determination

description: Related Article: U.D.Eckensberger, H.-W.Lerner, M.Bolte|2008|Acta Crystallogr.,Sect.E:Struct.Rep.Online|64|o1806|doi:10.1107/S1600536808026615
DOI: 10.5517/ccrl1zb
title: CCDC 702552: Experimental Crystal Structure Determination

description: Related Article: S.Murugavel, G.Ganesh, A.SubbiahPandi, R.Murugan, S.SrimanNarayanan|2008|Acta Crystallogr.,Sect.E:Struct.Rep.Online|64|o1807|doi:10.1107/S1600536808026603
DOI: 10.5517/ccpjtbb
title: CCDC 641772: Experimental Crystal Structure Determination

description: Related Article: R.Xu, X.Xu, D.Wang, X.Yang, X.Wang|2008|Acta Crystallogr.,Sect.E:Struct.Rep.Online|64|o1808|doi:10.1107/S1600536808026378
DOI: 10.5517/ccqyvm3
title: CCDC 684096: Experimental Crystal Structure Determination

description: Related Article: Wen-Kui Dong, Xue-Ni He, Y.-H.Guan, L.Xu, Z.-L.Ren|2008|Acta Crystallogr.,Sect.E:Struct.Rep.Online|64|o1810|doi:10.1107/S1600536808026731
DOI: 10.5517/ccrl20d
title: CCDC 702553: Experimental Crystal Structure Determination

description: Related Article: Guang-Hai Xu, Wei Wang|2008|Acta Crystallogr.,Sect.E:Struct.Rep.Online|64|o1811|doi:10.1107/S160053680802672X
DOI: 10.5517/ccrl71l
title: CCDC 702709: Experimental Crystal Structure Determination

description: Related Article: M.N.Mohideen, A.Rasheeth, C.A.M.A.Huq|2008|Acta Crystallogr.,Sect.E:Struct.Rep.Online|64|o1812|doi:10.1107/S1600536808026664
DOI: 10.5517/ccrl21f
title: CCDC 702554: Experimental Crystal Structure Determination

description: Related Article: M.Davison, R.A.Lalancette, H.W.Thompson, A.J.Miller|2008|Acta Crystallogr.,Sect.E:Struct.Rep.Online|64|o1813|doi:10.1107/S1600536808026639
DOI: 10.5517/ccrl22g
title: CCDC 702555: Experimental Crystal Structure Determination

description: Related Article: H.-K.Fun, P.S.Patil, S.M.Dharmaprakash, S.Chantrapromma, I.A.Razak|2008|Acta Crystallogr.,Sect.E:Struct.Rep.Online|64|o1814|doi:10.1107/S1600536808026524
DOI: 10.5517/ccrl23h
title: CCDC 702556: Experimental Crystal Structure Determination

description: Related Article: Xiujie Ji, Bowen Cheng, Jun Song, Chao Liu|2008|Acta Crystallogr.,Sect.E:Struct.Rep.Online|64|o1816|doi:10.1107/S1600536808026573
DOI: 10.5517/ccrl24j
title: CCDC 702557: Experimental Crystal Structure Determination

description: Related Article: S.Nirmala, R.Murugan, E.T.S.Kamala, L.Sudha, S.S.Narayanan|2008|Acta Crystallogr.,Sect.E:Struct.Rep.Online|64|o1817|doi:10.1107/S1600536808024781
DOI: 10.5517/ccrl25k
title: CCDC 702558: Experimental Crystal Structure Determination

description: Related Article: S.Ucan, A.Ozturk, N.Sarikavakli, T.Hokelek|2008|Acta Crystallogr.,Sect.E:Struct.Rep.Online|64|o1818|doi:10.1107/S1600536808026883
DOI: 10.5517/ccrl26l
title: CCDC 702559: Experimental Crystal Structure Determination

description: Related Article: N.D.Hassan, H.A.Tajuddin, Z.Abdullah, S.W.Ng|2008|Acta Crystallogr.,Sect.E:Struct.Rep.Online|64|o1820|doi:10.1107/S1600536808026809
DOI: 10.5517/ccrl27m
title: CCDC 702560: Experimental Crystal Structure Determination

description: Related Article: N.D.Hassan, H.A.Tajuddin, Z.Abdullah, S.W.Ng|2008|Acta Crystallogr.,Sect.E:Struct.Rep.Online|64|o1821|doi:10.1107/S1600536808026810
DOI: 10.5517/ccrl28n
title: CCDC 702561: Experimental Crystal Structure Determination

description: Related Article: N.D.Hassan, H.A.Tajuddin, Z.Abdullah, S.W.Ng|2008|Acta Crystallogr.,Sect.E:Struct.Rep.Online|64|o1822|doi:10.1107/S1600536808026822
DOI: 10.5517/ccrl29p
title: CCDC 702562: Experimental Crystal Structure Determination

description: Related Article: N.D.Hassan, H.A.Tajuddin, Z.Abdullah, S.W.Ng|2008|Acta Crystallogr.,Sect.E:Struct.Rep.Online|64|o1823|doi:10.1107/S1600536808026834
DOI: 10.5517/ccrl2bq
title: CCDC 702563: Experimental Crystal Structure Determination

description: Related Article: W.A.Yehye, N.A.Rahman, A.Ariffin, S.W.Ng|2008|Acta Crystallogr.,Sect.E:Struct.Rep.Online|64|o1824|doi:10.1107/S1600536808026846
DOI: 10.5517/ccrl2cr
title: CCDC 702564: Experimental Crystal Structure Determination

description: Related Article: B.T.Gowda, S.Foro, K.S.Babitha, H.Fuess|2008|Acta Crystallogr.,Sect.E:Struct.Rep.Online|64|o1825|doi:10.1107/S1600536808026895
DOI: 10.5517/ccrl2ds
title: CCDC 702565: Experimental Crystal Structure Determination

description: Related Article: H.D.Choi, P.J.Seo, B.W.Son, U.Lee|2008|Acta Crystallogr.,Sect.E:Struct.Rep.Online|64|o1826|doi:10.1107/S160053680802669X
DOI: 10.5517/ccrl72m
title: CCDC 702710: Experimental Crystal Structure Determination

description: Related Article: Z.-K.Lu, S.Li, Y.Feng|2008|Acta Crystallogr.,Sect.E:Struct.Rep.Online|64|o1827|doi:10.1107/S1600536808026858
DOI: 10.5517/ccrl4k0
title: CCDC 702632: Experimental Crystal Structure Determination

description: Related Article: M.Shahid, M.Mazhar, M.Helliwell, J.Akhtar, K.Ahmad|2008|Acta Crystallogr.,Sect.E:Struct.Rep.Online|64|m1139|doi:10.1107/S1600536808024148
DOI: 10.5517/ccrkwsy
title: CCDC 702391: Experimental Crystal Structure Determination

description: Related Article: Byeong Kwon Park, Kyung-Hwan Jang, Pan-Gi Kim, Cheal Kim, Youngmee Kim|2008|Acta Crystallogr.,Sect.E:Struct.Rep.Online|64|m1141|doi:10.1107/S1600536808024859
DOI: 10.5517/ccrkwx2
title: CCDC 702395: Experimental Crystal Structure Determination

description: Related Article: Xiang-Dang Du, Juan Mo, Xin-Sheng Li, Yu-Shan Pan, Su-Mei Zhang|2008|Acta Crystallogr.,Sect.E:Struct.Rep.Online|64|m1146|doi:10.1107/S1600536808024525
DOI: 10.5517/ccrl4s7
title: CCDC 702639: Experimental Crystal Structure Determination

description: Related Article: Hongling Liu, Daqi Wang|2008|Acta Crystallogr.,Sect.E:Struct.Rep.Online|64|m1148|doi:10.1107/S1600536808023830
DOI: 10.5517/ccrkwy3
title: CCDC 702396: Experimental Crystal Structure Determination

description: Related Article: C.Esterhuysen, I.B.J.Nel, S.Cronje|2008|Acta Crystallogr.,Sect.E:Struct.Rep.Online|64|m1150|doi:10.1107/S1600536808025245
DOI: 10.5517/ccrkwz4
title: CCDC 702397: Experimental Crystal Structure Determination

description: Related Article: Wen-Yan Liu, Hu Zhou, Ai-Hua Yuan|2008|Acta Crystallogr.,Sect.E:Struct.Rep.Online|64|m1151|doi:10.1107/S160053680802494X
DOI: 10.5517/ccq7ykf
title: CCDC 663045: Experimental Crystal Structure Determination

description: Related Article: Wen-Yan Liu, Hu Zhou, Ji-Xi Guo, Ai-Hua Yuan|2008|Acta Crystallogr.,Sect.E:Struct.Rep.Online|64|m1152|doi:10.1107/S1600536808024963
DOI: 10.5517/ccqw5h7
title: CCDC 681519: Experimental Crystal Structure Determination

description: Related Article: Chao-Xia Chu, Hu Zhou, Lang Liu, Ai-Hua Yuan|2008|Acta Crystallogr.,Sect.E:Struct.Rep.Online|64|m1154|doi:10.1107/S1600536808024951
DOI: 10.6084/m9.figshare.9885416.v1
title: Long-term asthma-related readmissions: comparison between children admitted and not admitted to the intensive care unit for critical asthma

description: To compare the time to asthma-related readmission between children admitted to the intensive care unit (ICU) for asthma and those with a non-ICU hospitalization in the United States and to explore risk factors associated with readmission among children admitted in the ICU. In this retrospective cohort study, we included children aged 2–17 years in the State Inpatient Database (2005-2014) from four U.S. states who were hospitalized for asthma. We compared the time to asthma-related readmissions and emergency department (ED) visit between children admitted and not admitted to the ICU using the log-rank test. Among those admitted to the ICU, we explored factors associated with readmission using Cox regression. 66 835 children were hospitalized for asthma, with 14.0% admitted to the ICU, and 12 844 were readmitted for asthma while 22 915 had an asthma-related ED visit. The time to asthma-related readmission was shorter in the ICU group compared to the non-ICU group (<i>p</i> p = 0.43). Being preschool-aged, female, Black, and having lower household income and a longer length of stay during the initial hospitalization conferred a higher risk of asthma-related readmission among children admitted to the ICU. Preschool age and Medicaid were Florida-specific risk factors while Hispanic ethnicity was New York-specific. Compared to children not admitted to the ICU, children admitted to the ICU for asthma were at increased risk of asthma-related readmission, with certain risk factors conferring an even higher risk.
DOI: 10.6084/m9.figshare.9975947
title: Medication adherence in patients with asthma using once-daily versus twice-daily ICS/LABAs

description: This real-world observational study compared medication adherence and persistence among patients with asthma receiving the once-daily inhaled corticosteroid/long-acting β<sub>2</sub>-agonist (ICS/LABA) fluticasone furoate/vilanterol (FF/VI) versus the twice-daily ICS/LABAs budesonide/formoterol (B/F) and fluticasone propionate/salmeterol (FP/SAL). This retrospective cohort study conducted using IQVIA<sup>TM</sup> Health Plan Claims Data included patients with asthma ≥18 years of age initiating ICS/LABA therapy with FF/VI, B/F, or FP/SAL between January 1, 2014 and June 30, 2016 (index date). Patients had ≥12 months and ≥3 months of continuous eligibility pre- and post-index date, respectively. Patients receiving FF/VI were separately matched 1:1 with patients receiving B/F or FP/SAL using propensity score matching (PSM) and multivariable regression to balance baseline covariates between cohorts. The primary endpoint was medication adherence, measured by proportion of days covered (PDC). Secondary endpoints included proportion of patients achieving PDC ≥ 0.5 and PDC ≥ 0.8 and persistence with index medication, measured by time to discontinuation (&gt;45-day gap in therapy). After PSM, 3,764 and 3,339 patients receiving FF/VI were matched with patients receiving B/F or FP/SAL, respectively. Mean PDC was significantly higher for FF/VI versus B/F (0.453 vs 0.345; adjusted <i>p</i> p p In this real-world study, patients initiating FF/VI had better adherence and lower risk of discontinuing treatment versus B/F or FP/SAL, suggesting that once-daily ICS/LABA treatment might improve adherence and persistence compared with twice-daily alternatives.
DOI: 10.6084/m9.figshare.9975947.v1
title: Medication adherence in patients with asthma using once-daily versus twice-daily ICS/LABAs

description: This real-world observational study compared medication adherence and persistence among patients with asthma receiving the once-daily inhaled corticosteroid/long-acting β<sub>2</sub>-agonist (ICS/LABA) fluticasone furoate/vilanterol (FF/VI) versus the twice-daily ICS/LABAs budesonide/formoterol (B/F) and fluticasone propionate/salmeterol (FP/SAL). This retrospective cohort study conducted using IQVIA<sup>TM</sup> Health Plan Claims Data included patients with asthma ≥18 years of age initiating ICS/LABA therapy with FF/VI, B/F, or FP/SAL between January 1, 2014 and June 30, 2016 (index date). Patients had ≥12 months and ≥3 months of continuous eligibility pre- and post-index date, respectively. Patients receiving FF/VI were separately matched 1:1 with patients receiving B/F or FP/SAL using propensity score matching (PSM) and multivariable regression to balance baseline covariates between cohorts. The primary endpoint was medication adherence, measured by proportion of days covered (PDC). Secondary endpoints included proportion of patients achieving PDC ≥ 0.5 and PDC ≥ 0.8 and persistence with index medication, measured by time to discontinuation (&gt;45-day gap in therapy). After PSM, 3,764 and 3,339 patients receiving FF/VI were matched with patients receiving B/F or FP/SAL, respectively. Mean PDC was significantly higher for FF/VI versus B/F (0.453 vs 0.345; adjusted <i>p</i> p p In this real-world study, patients initiating FF/VI had better adherence and lower risk of discontinuing treatment versus B/F or FP/SAL, suggesting that once-daily ICS/LABA treatment might improve adherence and persistence compared with twice-daily alternatives.
DOI: 10.6084/m9.figshare.9885416
title: Long-term asthma-related readmissions: comparison between children admitted and not admitted to the intensive care unit for critical asthma

description: To compare the time to asthma-related readmission between children admitted to the intensive care unit (ICU) for asthma and those with a non-ICU hospitalization in the United States and to explore risk factors associated with readmission among children admitted in the ICU. In this retrospective cohort study, we included children aged 2–17 years in the State Inpatient Database (2005-2014) from four U.S. states who were hospitalized for asthma. We compared the time to asthma-related readmissions and emergency department (ED) visit between children admitted and not admitted to the ICU using the log-rank test. Among those admitted to the ICU, we explored factors associated with readmission using Cox regression. 66 835 children were hospitalized for asthma, with 14.0% admitted to the ICU, and 12 844 were readmitted for asthma while 22 915 had an asthma-related ED visit. The time to asthma-related readmission was shorter in the ICU group compared to the non-ICU group (<i>p</i> p = 0.43). Being preschool-aged, female, Black, and having lower household income and a longer length of stay during the initial hospitalization conferred a higher risk of asthma-related readmission among children admitted to the ICU. Preschool age and Medicaid were Florida-specific risk factors while Hispanic ethnicity was New York-specific. Compared to children not admitted to the ICU, children admitted to the ICU for asthma were at increased risk of asthma-related readmission, with certain risk factors conferring an even higher risk.
DOI: 10.6084/m9.figshare.13109737
title: “Capturing your audience”: analysis of Twitter engagements between tweets linked with an educational infographic or a peer-reviewed journal article

description: Information represented through conventional text may fall short of capturing the attention and promoting engagement with today’s digital audience. Transforming text into visual tools, such as infographics, has emerged as a simplified method of delivering information to attract a broader audience and enhance information dissemination. The first step to evaluate the potential value of infographics is to quantify their appeal and engagement rates over conventional text. This retrospective pilot analysis sought to evaluate the difference between engagement rates for tweets containing an of infographic compared to tweets containing a link to a peer-reviewed journal article. A total of 752 tweets were published within the study period; of these, 40 tweets met inclusion criteria. When engagement rates were compared, there was an increase in median engagement rates for tweets containing an infographic compared to a tweet linked to a peer-reviewed article at 10.97% (IQR 3.47%) and 5.33% (IQR 3.17%), respectively. This pilot study provides insight on the potential impact for infographics to enhance engagement rate, which may subsequently correlate with an increase in audience reach and readership. Prospective studies are needed to validate the utility of infographics in promoting scholarship publicity, learner engagement, and as a transferable pedagogical tool to educate medical practitioners.
DOI: 10.6084/m9.figshare.13109737.v1
title: “Capturing your audience”: analysis of Twitter engagements between tweets linked with an educational infographic or a peer-reviewed journal article

description: Information represented through conventional text may fall short of capturing the attention and promoting engagement with today’s digital audience. Transforming text into visual tools, such as infographics, has emerged as a simplified method of delivering information to attract a broader audience and enhance information dissemination. The first step to evaluate the potential value of infographics is to quantify their appeal and engagement rates over conventional text. This retrospective pilot analysis sought to evaluate the difference between engagement rates for tweets containing an of infographic compared to tweets containing a link to a peer-reviewed journal article. A total of 752 tweets were published within the study period; of these, 40 tweets met inclusion criteria. When engagement rates were compared, there was an increase in median engagement rates for tweets containing an infographic compared to a tweet linked to a peer-reviewed article at 10.97% (IQR 3.47%) and 5.33% (IQR 3.17%), respectively. This pilot study provides insight on the potential impact for infographics to enhance engagement rate, which may subsequently correlate with an increase in audience reach and readership. Prospective studies are needed to validate the utility of infographics in promoting scholarship publicity, learner engagement, and as a transferable pedagogical tool to educate medical practitioners.
DOI: 10.6084/m9.figshare.10290479
title: Comparative safety and effectiveness of inhaled bronchodilators and corticosteroids for treating asthma–COPD overlap: a systematic review and meta-analysis

description: To determine the safety and effectiveness of current pharmacotherapies consisting of long-acting beta<sub>2</sub>-agonist (LABA) and/or inhaled corticosteroids (ICS) in patients with asthma–COPD overlap. A systematic search was conducted using the PubMed, EMBASE, and Web of Science databases up to June 2018. Only studies comparing the safety and effectiveness of LABA and/or ICS in patients with asthma–COPD overlap were included. A meta-analysis was performed to calculate risk ratio (RR) and 95% confidence interval (CI) using Inverse Variance Random-effects model. From a total of 3382 articles retrieved, three randomized controlled trials (RCTs), six cohort studies (CS), one nested case control study fulfilled the inclusion criteria for three independent meta-analyses representing 181,603 participants. Three CS results show LABA was associated with decreased risk of myocardial infarction (combined RR: 0.80, 95% CI 0.74–0.87) versus non-LABA use; ICS/LABA was associated with a lower risk of death or hospitalization (combined RR: 0.82, 95% CI 0.75–0.90) compared to no use. Results from RCTs, no clear difference in lung function decline in FEV<sub>1</sub> was found (combined mean difference: 0.08, 95% CI 0.15–0.32) in patients receiving ICS and/or LABA compared to placebo. However, due to lack of data, exacerbations, fractures and nontuberculous mycobacterial pulmonary disease outcomes were not meta-analyzed. Among patients with asthma–COPD overlap, LABA is associated with decreased risk of myocardial infarction; and the combination therapy of ICS/LABA appears to reduce the risk of death or hospitalization. More studies of quality data and larger number of patients are needed. PROSPERO (CRD42018090863).
DOI: 10.6084/m9.figshare.10290479.v1
title: Comparative safety and effectiveness of inhaled bronchodilators and corticosteroids for treating asthma–COPD overlap: a systematic review and meta-analysis

description: To determine the safety and effectiveness of current pharmacotherapies consisting of long-acting beta<sub>2</sub>-agonist (LABA) and/or inhaled corticosteroids (ICS) in patients with asthma–COPD overlap. A systematic search was conducted using the PubMed, EMBASE, and Web of Science databases up to June 2018. Only studies comparing the safety and effectiveness of LABA and/or ICS in patients with asthma–COPD overlap were included. A meta-analysis was performed to calculate risk ratio (RR) and 95% confidence interval (CI) using Inverse Variance Random-effects model. From a total of 3382 articles retrieved, three randomized controlled trials (RCTs), six cohort studies (CS), one nested case control study fulfilled the inclusion criteria for three independent meta-analyses representing 181,603 participants. Three CS results show LABA was associated with decreased risk of myocardial infarction (combined RR: 0.80, 95% CI 0.74–0.87) versus non-LABA use; ICS/LABA was associated with a lower risk of death or hospitalization (combined RR: 0.82, 95% CI 0.75–0.90) compared to no use. Results from RCTs, no clear difference in lung function decline in FEV<sub>1</sub> was found (combined mean difference: 0.08, 95% CI 0.15–0.32) in patients receiving ICS and/or LABA compared to placebo. However, due to lack of data, exacerbations, fractures and nontuberculous mycobacterial pulmonary disease outcomes were not meta-analyzed. Among patients with asthma–COPD overlap, LABA is associated with decreased risk of myocardial infarction; and the combination therapy of ICS/LABA appears to reduce the risk of death or hospitalization. More studies of quality data and larger number of patients are needed. PROSPERO (CRD42018090863).