cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.2069581.v2
title: Ecology and sustainability issues in religious: An analysis

description: Science, technology and sustainability article try to tell the situation that happen in today routine life. This article explains on how does Islamic perspective in handle and solving the issue arises in environment and ecology. The article starts by giving definition on the world view from the glass of Islamic and western doctrine and understanding on environment. Next the article explains on why does human has the responsibility on governs the nature and should not make no harm upon the environment. Environmentalethic that the western civilization practices reflects the action that the western people do when dealing with the environment. Islamic perspective seems to be the best alternative in dealing and helping the nature to heal from the corruption that it faced. In conclusion the article hopes that, Islamic approach for environment issue method can be one of the choice in future in order to settle or drafting the policy.
DOI: 10.6084/m9.figshare.2069622.v7
title: Additional files for paper "Plasma metabolome signature in patients with early-stage Parkinson disease".

description: Patients.pdf - Clinical characteristics of patients. Mass list.zip - Mass lists.Mass spectra.zip - Mass spectra in mzXL format. Mass spectra.tif - Mass spectra (screenshots) of the metabolites listed in the Table 2.<br><br>
DOI: 10.6084/m9.figshare.2069622.v6
title: Additional files for paper "Diagnosing Parkinson's disease using metabolome signature of blood plasma".

description: Patients.pdf - Clinical characteristics of patients. Mass list.zip - Mass lists.Mass spectra.zip - Mass spectra in mzXL format. <br>
DOI: 10.6084/m9.figshare.2069553.v2
title: Promoting Similarity of Sparsity Structures in Integrative Analysis With Penalization

description: For data with high-dimensional covariates but small sample sizes, the analysis of single datasets often generates unsatisfactory results. The integrative analysis of multiple independent datasets provides an effective way of pooling information and outperforms single-dataset and several alternative multi-datasets methods. Under many scenarios, multiple datasets are expected to share common important covariates, that is, the corresponding models have similarity in their sparsity structures. However, the existing methods do not have a mechanism to promote the similarity in sparsity structures in integrative analysis. In this study, we consider penalized variable selection and estimation in integrative analysis. We develop an <i>L</i><sub>0</sub>-penalty-based method, which explicitly promotes the similarity in sparsity structures. Computationally it is realized using a coordinate descent algorithm. Theoretically it has the selection and estimation consistency properties. Under a wide spectrum of simulation scenarios, it has identification and estimation performance comparable to or better than the alternatives. In the analysis of three lung cancer datasets with gene expression measurements, it identifies genes with sound biological implications and satisfactory prediction performance. Supplementary materials for this article are available online.
DOI: 10.6084/m9.figshare.2069529
title: Cognitive control of saccadic eye movements in children with developmental coordination disorder

description: The ability to prepare and execute a movement in response to advance information requires cognitive control of behaviour (e.g., attention control and prediction). Our aim was to explore the integrity of forward models in eye movement control and examine the ability of children with DCD and typically developing children (TD) (8-12 yrs) to plan and inhibit their saccadic responses (i.e., the inhibition and anticipation mechanisms involved in attention control). Eye movements and touch responses were measured (separately and concurrently during coordination) in Cued and Non-Cued conditions. Children with DCD showed normal saccadic kinematics, including saccade initiation. Cue information decreased movement duration in both groups but touch accuracy was worse in the DCD group. Children with DCD exhibited increased inhibitory errors and inaccurate fixation in the Cued trials. Children with DCD seem proficient in executing saccades, but show deficits in more complex processing such as inhibition. The lack of inhibitory control had a direct impact on the allocation of visual attention and hindered the motor program compared to TD controls. Saccadic control and attentional deficits (lack of inhibition) may explain why internal models needed for motor programming are compromised. These findings have implications for theories regarding the aetiology of DCD.
DOI: 10.6084/m9.figshare.2069541
title: Association between Prehospital CPR Quality and End-Tidal Carbon Dioxide Levels in Out-of-Hospital Cardiac Arrest

description: <b>Introduction:</b> International Guidelines recommend measurement of end-tidal carbon dioxide (EtCO<sub>2</sub>) to enhance cardiopulmonary resuscitation (CPR) quality and optimize blood flow during CPR. Numerous factors impact EtCO<sub>2</sub> (e.g., ventilation, metabolism, cardiac output), yet few clinical studies have correlated CPR quality and EtCO<sub>2</sub> during actual out-of-hospital cardiac arrest (OHCA) resuscitations. The purpose of this study was to describe the association between EtCO<sub>2</sub> and CPR quality variables during OHCA. <b>Methods:</b> This is an observational study of prospectively collected CPR quality and capnography data from two EMS agencies participating in a statewide resuscitation quality improvement program. CPR quality and capnography data from adult (≥18 years) cardiac resuscitation attempts (10/2008–06/2013) were collected and analyzed on a minute-by-minute basis using RescueNet™ Code Review. Linear mixed effect models were used to evaluate the association between (log-transformed) EtCO<sub>2</sub> level and CPR variables: chest compression (CC) depth, CC rate, CC release velocity (CCRV), ventilation rate. <b>Results:</b> Among the 1217 adult OHCA cases of presumed cardiac etiology, 925 (76.0%) had a monitor-defibrillator file with CPR quality data, of which 296 (32.0%) cases had &gt;1 minute of capnography data during CPR. After capnography quality review, 66 of these cases (22.3%) were excluded due to uninterpretable capnography, resulting in a final study sample of 230 subjects (mean age 68 years; 69.1% male), with a total of 1581 minutes of data. After adjustment for other CPR variables, a 10 mm increase in CC depth was associated with a 4.0% increase in EtCO<sub>2</sub> (<i>p</i> &lt; 0.0001), a 10 compression/minute increase in CC rate with a 1.7% increase in EtCO<sub>2</sub> (<i>p</i> = 0.02), a 10 mm/second increase in CCRV with a 2.8% increase in EtCO<sub>2</sub> (<i>p</i> = 0.03), and a 10 breath/minute increase in ventilation rate with a 17.4% decrease in EtCO<sub>2</sub> (<i>p</i> &lt; 0.0001). <b>Conclusion:</b> When controlling for known CPR quality variables, increases in CC depth, CC rate and CCRV were each associated with a statistically significant but clinically modest increase in EtCO<sub>2</sub>. Given the small effect sizes, the clinical utility of using EtCO<sub>2</sub> to guide CPR performance is unclear. Further research is needed to determine the practicality and impact of using real-time EtCO<sub>2</sub> to guide CPR delivery in the prehospital environment.
DOI: 10.6084/m9.figshare.2069553.v1
title: Promoting Similarity of Sparsity Structures in Integrative Analysis with Penalization

description: For data with high-dimensional covariates but small sample sizes, the analysis of single datasets often generates unsatisfactory results. The integrative analysis of multiple independent datasets provides an effective way of pooling information and outperforms single-dataset and several alternative multi-datasets methods. Under many scenarios, multiple datasets are expected to share common important covariates, that is, the corresponding models have similarity in their sparsity structures. However, the existing methods do not have a mechanism to promote the similarity in sparsity structures in integrative analysis. In this study, we consider penalized variable selection and estimation in integrative analysis. We develop an <i>L</i><sub>0</sub>-penalty based method, which explicitly promotes the similarity in sparsity structures. Computationally it is realized using a coordinate descent algorithm. Theoretically it has the selection and estimation consistency properties. Under a wide spectrum of simulation scenarios, it has identification and estimation performance comparable to or better than the alternatives. In the analysis of three lung cancer datasets with gene expression measurements, it identifies genes with sound biological implications and satisfactory prediction performance.
DOI: 10.6084/m9.figshare.2069529.v2
title: Cognitive control of saccadic eye movements in children with developmental coordination disorder

description: The ability to prepare and execute a movement in response to advance information requires cognitive control of behaviour (e.g., attention control and prediction). Our aim was to explore the integrity of forward models in eye movement control and examine the ability of children with DCD and typically developing children (TD) (8-12 yrs) to plan and inhibit their saccadic responses (i.e., the inhibition and anticipation mechanisms involved in attention control). Eye movements and touch responses were measured (separately and concurrently during coordination) in Cued and Non-Cued conditions. Children with DCD showed normal saccadic kinematics, including saccade initiation. Cue information decreased movement duration in both groups but touch accuracy was worse in the DCD group. Children with DCD exhibited increased inhibitory errors and inaccurate fixation in the Cued trials. Children with DCD seem proficient in executing saccades, but show deficits in more complex processing such as inhibition. The lack of inhibitory control had a direct impact on the allocation of visual attention and hindered the motor program compared to TD controls. Saccadic control and attentional deficits (lack of inhibition) may explain why internal models needed for motor programming are compromised. These findings have implications for theories regarding the aetiology of DCD.
DOI: 10.6084/m9.figshare.2069541.v1
title: Association between Prehospital CPR Quality and End-Tidal Carbon Dioxide Levels in Out-of-Hospital Cardiac Arrest

description: <b>Introduction:</b> International Guidelines recommend measurement of end-tidal carbon dioxide (EtCO<sub>2</sub>) to enhance cardiopulmonary resuscitation (CPR) quality and optimize blood flow during CPR. Numerous factors impact EtCO<sub>2</sub> (e.g., ventilation, metabolism, cardiac output), yet few clinical studies have correlated CPR quality and EtCO<sub>2</sub> during actual out-of-hospital cardiac arrest (OHCA) resuscitations. The purpose of this study was to describe the association between EtCO<sub>2</sub> and CPR quality variables during OHCA. <b>Methods:</b> This is an observational study of prospectively collected CPR quality and capnography data from two EMS agencies participating in a statewide resuscitation quality improvement program. CPR quality and capnography data from adult (≥18 years) cardiac resuscitation attempts (10/2008–06/2013) were collected and analyzed on a minute-by-minute basis using RescueNet™ Code Review. Linear mixed effect models were used to evaluate the association between (log-transformed) EtCO<sub>2</sub> level and CPR variables: chest compression (CC) depth, CC rate, CC release velocity (CCRV), ventilation rate. <b>Results:</b> Among the 1217 adult OHCA cases of presumed cardiac etiology, 925 (76.0%) had a monitor-defibrillator file with CPR quality data, of which 296 (32.0%) cases had &gt;1 minute of capnography data during CPR. After capnography quality review, 66 of these cases (22.3%) were excluded due to uninterpretable capnography, resulting in a final study sample of 230 subjects (mean age 68 years; 69.1% male), with a total of 1581 minutes of data. After adjustment for other CPR variables, a 10 mm increase in CC depth was associated with a 4.0% increase in EtCO<sub>2</sub> (<i>p</i> &lt; 0.0001), a 10 compression/minute increase in CC rate with a 1.7% increase in EtCO<sub>2</sub> (<i>p</i> = 0.02), a 10 mm/second increase in CCRV with a 2.8% increase in EtCO<sub>2</sub> (<i>p</i> = 0.03), and a 10 breath/minute increase in ventilation rate with a 17.4% decrease in EtCO<sub>2</sub> (<i>p</i> &lt; 0.0001). <b>Conclusion:</b> When controlling for known CPR quality variables, increases in CC depth, CC rate and CCRV were each associated with a statistically significant but clinically modest increase in EtCO<sub>2</sub>. Given the small effect sizes, the clinical utility of using EtCO<sub>2</sub> to guide CPR performance is unclear. Further research is needed to determine the practicality and impact of using real-time EtCO<sub>2</sub> to guide CPR delivery in the prehospital environment.
DOI: 10.6084/m9.figshare.2069529.v1
title: Cognitive control of saccadic eye movements during movement planning in children with developmental coordination disorder

description: The ability to prepare and execute a movement in response to advance information requires cognitive control of behaviour (e.g., attention control and prediction). Our aim was to explore the integrity of forward models in eye movement control and examine the ability of children with DCD and typically developing children (TD) (8-12 yrs) to plan and inhibit their saccadic responses (i.e., the inhibition and anticipation mechanisms involved in attention control). Eye movements and touch responses were measured (separately and concurrently during coordination) in Cued and Non-Cued conditions. Children with DCD showed normal saccadic kinematics, including saccade initiation. Cue information decreased movement duration in both groups but touch accuracy was worse in the DCD group. Children with DCD exhibited increased inhibitory errors and inaccurate fixation in the Cued trials. Children with DCD seem proficient in executing saccades, but show deficits in more complex processing such as inhibition. The lack of inhibitory control had a direct impact on the allocation of visual attention and hindered the motor program compared to TD controls. Saccadic control and attentional deficits (lack of inhibition) may explain why internal models needed for motor programming are compromised. These findings have implications for theories regarding the aetiology of DCD.
DOI: 10.6084/m9.figshare.2069496
title: The elusive quest for RNA knots

description: Physical entanglement, and particularly knots arise spontaneously in equilibrated polymers that are sufficiently long and densely packed. Biopolymers are no exceptions: knots have long been known to occur in proteins as well as in encapsidated viral DNA. The rapidly growing number of RNA structures has recently made it possible to investigate the incidence of physical knots in this type of biomolecule, too. Strikingly, no knots have been found to date in the known RNA structures. In this Point of View Article we discuss the absence of knots in currently available RNAs and consider the reasons why knots in RNA have not yet been found, despite the expectation that they should exist in Nature. We conclude by singling out a number of RNA sequences that, based on the properties of their predicted secondary structures, are good candidates for knotted RNAs.
DOI: 10.6084/m9.figshare.2069496.v2
title: The elusive quest for RNA knots

description: Physical entanglement, and particularly knots arise spontaneously in equilibrated polymers that are sufficiently long and densely packed. Biopolymers are no exceptions: knots have long been known to occur in proteins as well as in encapsidated viral DNA. The rapidly growing number of RNA structures has recently made it possible to investigate the incidence of physical knots in this type of biomolecule, too. Strikingly, no knots have been found to date in the known RNA structures. In this Point of View Article we discuss the absence of knots in currently available RNAs and consider the reasons why knots in RNA have not yet been found, despite the expectation that they should exist in Nature. We conclude by singling out a number of RNA sequences that, based on the properties of their predicted secondary structures, are good candidates for knotted RNAs.
DOI: 10.6084/m9.figshare.2069487
title: Supplemental materials

description: The opposite roles of routine and activity metabolic rate in driving variation in the predictability of behaviour in hermit crabs: Supplemental materials
DOI: 10.6084/m9.figshare.2069478
title: Computed List of Collision Strengths for [Co II] Forbidden Lines

description: The list presents electron collision strengths for the forbidden transitions between the fifteen lowest levels of the singly-ionized cobalt, Co^{+}, as a function of the electron energy, in an intermediate coupling scheme using the Breit-Pauli relativistic terms as implemented in an R-matrix atomic scattering code. An atomic target for the R-matrix scattering defined by 26 atomic terms is used in these calculations. The data are particularly useful for analyzing the thermodynamic conditions of supernova ejecta.
DOI: 10.6084/m9.figshare.2069481
title: Computed List of Collision Strengths for [Co III] Forbidden Lines

description: The list presents electron collision strengths for the forbidden transitions between the fifteen lowest levels of the doubly-ionized cobalt, Co^{2+}, as a function of the electron energy, in an intermediate coupling scheme using the Breit-Pauli relativistic terms as implemented in an R-matrix atomic scattering code. An atomic target for the R-matrix scattering defined by 36 atomic terms is used in these calculations. The data are particularly useful for analyzing the thermodynamic conditions of supernova ejecta.
DOI: 10.6084/m9.figshare.2069484
title: Cellular mRNA recruits the ribosome via eIF3-PABP bridge to initiate internal translation

description: IRES-mediated translation of key cell fate regulating genes has been implicated in tumorigenesis. Concerted action of canonical eukaryotic initiation factors and IRES transacting factors (ITAFs) was shown to regulate cellular IRES mediated translation; however, the precise molecular mechanism of ribosome recruitment to cellular IRESes remains unclear. Here we show that the X-linked inhibitor of apoptosis (XIAP) IRES operates in an evolutionary conserved viral like mode and the structural integrity, particularly in the vicinity of AUG, is critical for ribosome recruitment. The binding of eIF3 together with PABP potentiates ribosome recruitment to the IRES. Our data support the model in which eIF3 binds directly to the XIAP IRES RNA in a structure-dependent manner and acts as a scaffold for IRES RNA, PABP and the 40S ribosome.
DOI: 10.6084/m9.figshare.2069484.v1
title: Cellular mRNA recruits the ribosome via eIF3-PABP bridge to initiate internal translation

description: IRES-mediated translation of key cell fate regulating genes has been implicated in tumorigenesis. Concerted action of canonical eukaryotic initiation factors and IRES transacting factors (ITAFs) was shown to regulate cellular IRES mediated translation; however, the precise molecular mechanism of ribosome recruitment to cellular IRESes remains unclear. Here we show that the X-linked inhibitor of apoptosis (XIAP) IRES operates in an evolutionary conserved viral like mode and the structural integrity, particularly in the vicinity of AUG, is critical for ribosome recruitment. The binding of eIF3 together with PABP potentiates ribosome recruitment to the IRES. Our data support the model in which eIF3 binds directly to the XIAP IRES RNA in a structure-dependent manner and acts as a scaffold for IRES RNA, PABP and the 40S ribosome.
DOI: 10.6084/m9.figshare.2069487.v1
title: Supplemental materials

description: The opposite roles of routine and activity metabolic rate in driving variation in the predictability of behaviour in hermit crabs: Supplemental materials
DOI: 10.6084/m9.figshare.2069478.v1
title: Computed List of Collision Strengths for [Co II] Forbidden Lines

description: The list presents electron collision strengths for the forbidden transitions between the fifteen lowest levels of the singly-ionized cobalt, Co^{+}, as a function of the electron energy, in an intermediate coupling scheme using the Breit-Pauli relativistic terms as implemented in an R-matrix atomic scattering code. An atomic target for the R-matrix scattering defined by 26 atomic terms is used in these calculations. The data are particularly useful for analyzing the thermodynamic conditions of supernova ejecta.
DOI: 10.6084/m9.figshare.2069463
title: Periconceptional folate consumption is associated with neonatal DNA methylation modifications in neural crest regulatory and cancer development genes

description: Folate deficiency during early embryonic development constitutes a risk factor for neural tube defects and potentially for childhood leukemia via unknown mechanisms. We tested whether folate consumption during the 12 months prior to conception induced DNA methylation modifications at birth in healthy neonates with a genome-wide and agnostic approach. We hypothesized that DNA methylation in genes involved in neural tube development and/or cancer susceptibility would be affected by folate exposure. We retrospectively assessed folate exposure at the time of conception by food-frequency questionnaires administered to the mothers of 343 healthy newborns. We measured genome-wide DNA methylation from neonatal blood spots. We implemented a method based on bootstrap resampling to decrease false-positive findings. Folate was inversely associated with DNA methylation throughout the genome. Among the top folate-associated genes that were replicated in an independent Gambian study were <i>TFAP2A</i>, a gene critical for neural crest development, <i>STX11</i>, a gene implicated in acute myeloid leukemia, and <i>CYS1</i>, a candidate gene for cystic kidney disease. Reduced periconceptional folate intake was associated with increased methylation and, in turn, decreased gene expression at these 3 loci. The top folate-sensitive genes defined by their associated CpG sites were enriched for numerous transcription factors by Gene Set Enrichment Analysis, including those implicated in cancer development (e.g., <i>MYC</i>-associated zinc finger protein). The influence of estimated periconceptional folate intake on neonatal DNA methylation levels provides potential mechanistic insights into the role of this vitamin in the development of neural tube defects and childhood cancers.
DOI: 10.6084/m9.figshare.2069481.v1
title: Computed List of Collision Strengths for [Co III] Forbidden Lines

description: The list presents electron collision strengths for the forbidden transitions between the fifteen lowest levels of the doubly-ionized cobalt, Co^{2+}, as a function of the electron energy, in an intermediate coupling scheme using the Breit-Pauli relativistic terms as implemented in an R-matrix atomic scattering code. An atomic target for the R-matrix scattering defined by 36 atomic terms is used in these calculations. The data are particularly useful for analyzing the thermodynamic conditions of supernova ejecta.