cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.27311484
title: Dataset and species distribution modeling procedure performed in "Crossing borders: Connectivity analyses reveal potential patterns of range expansion of the Northern raccoon in Europe"

description: "Raccoon - occurrences&backgrounds.Rdata" contains a table with environmental characteristcs at occurrence and background locations for raccoon in its native range.<br>"Raccoon species distribution models.R" is the script used to perform variable selection and regularization of model parameters by using spatially-separated testing data.<br>"Output maps.zip" contains the geoTIFF maps of suitaiblity, resistance, and connectivity for the raccoon in Europe, along with a raster indicating areas outside of model calibration, and .qml files that can be used to visualize the maps as they are presented in the paper.
DOI: 10.17632/mxf365z2f8.1
title: Effects of different acid rain types on global soil nitrogen pools

description: Effects of different acid rain types on global soil nitrogen pools
DOI: 10.15468/dl.t2maev
title: Occurrence Download

description: A dataset containing 11 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is China",
 "TaxonKey is Rhododendron densifolium K.M.Feng"
 ]
}

 The dataset includes 11 records from 4 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0001357-250424135625364/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.b8yvkw
title: Occurrence Download

description: A dataset containing 1043 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is China",
 "TaxonKey is Rhododendron irroratum Franch."
 ]
}

 The dataset includes 1043 records from 26 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0001359-250424135625364/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.fpt7nh
title: Occurrence Download

description: A dataset containing 9 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is China",
 "TaxonKey is Rhododendron elegantulum Tagg & Forrest"
 ]
}

 The dataset includes 9 records from 4 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0001360-250424135625364/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.18150/zn2w47
title: Induction of Infectious Pancreatic Necrosis (IPN) in brook trout (Salvelinus fontinalis) and rainbow brook trout (Salvelinus fontinalis x Oncorhynchus mykiss) using microinjection challenge with infectious pancreatic necrosis virus (IPNV)

description: The datasets are part of research aimed to compare the susceptibility to infection with Infectious Pancreatic Necrosis Virus (IPNV) of salmonids from the Salmoninae subfamily: brook trout Salvelinus fontinalis and its interspecific cross with rainbow trout, i.e., rainbow brook trout Salvelinus fontinalis x Oncorhynchus mykiss.
DOI: 10.15468/dl.x9ey9z
title: Occurrence Download

description: A dataset containing 768 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is one of (China, Chinese Taipei)",
 "TaxonKey is Rhododendron selense Franch."
 ]
}

 The dataset includes 768 records from 20 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0001116-250424135625364/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.4bv6y2
title: Occurrence Download

description: A dataset containing 12 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Xenodermichthys copei (Gill, 1884)",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "BasisOfRecord is one of (Specimen, Living Specimen, Observation, Human Observation, Machine Observation, Material sample, Literature Occurrence, Material citation, Occurrence evidence)",
 "Geometry POLYGON ((9.2698 2.0276,9.1702 1.8496,17.9648 1.8496,17.9648 10.8496,8.9648 10.8496,8.9648 2.8113,8.9984 2.8234,9.2654 3.2175,9.4253 3.0783,9.2698 2.0276))"
 ]
}

 The dataset includes 12 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0010575-250525065834625/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.17898/adp_evara17_v1
title: Anketa o motivaciji za zaščito pred kibernetskimi napadi v visokem šolstvu, 2017

description: Namen raziskave je bil preučiti dejavnike, povezane z motivacijo za varovanje pred kibernetskimi napadi posameznikov v organizacijah. Cilji raziskave so bili ugotoviti, kako so strah pred kibernetskimi napadi, zaznana resnost, zaznana ranljivost, zaznana tveganja, učinkovitost ukrepa, samoučinkovitost, stroški ukrepa, obveznost in psihološka reaktanca povezani z motivacijo za zaščito posameznikov v organizacijah. Anketa je bila izvedena med raziskovalci in pedagogi na šestih slovenskih univerzah. Vprašalnik in podatkovna datoteka sta dostopna v slovenskem in angleškem jeziku.
DOI: 10.17898/adp_evara17_v1/1
title: evara17_p1_en_v1_r3.tab

description: :unav
DOI: 10.17898/adp_evara17_v1/2
title: evara17_p1_sl_v1_r3.tab

description: :unav
DOI: 10.17898/adp_evara17_v1/3
title: evara17_vp1_en_v1_r1.pdf

description: :unav
DOI: 10.17898/adp_evara17_v1/4
title: evara17_vp1_sl_v1_r1.pdf

description: :unav
DOI: 10.15468/dl.wtcr89
title: Occurrence Download

description: A dataset containing 163 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is Costa Rica",
 "TaxonKey is Calopogonium caeruleum (Benth.) C.Wright"
 ]
}

 The dataset includes 163 records from 17 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0015723-250525065834625/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.kx3szg
title: Occurrence Download

description: A dataset containing 52 species occurrences available in GBIF matching the query:
{
 "and" : [
 "BasisOfRecord is Specimen",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 "TaxonKey is Cryptotis niausa Moreno & Albuja, 2014"
 ]
}

 The dataset includes 52 records from 3 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0015722-250525065834625/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.5281/zenodo.15547475
title: Supplementary Materials for: Moderate Social Support and Its Predictors in Elderly Intestinal Stoma Patients of Guangxi: A Quantitative Study with Multivariate Modeling
DOI: 10.5281/zenodo.15547476
title: Supplementary Materials for: Moderate Social Support and Its Predictors in Elderly Intestinal Stoma Patients of Guangxi: A Quantitative Study with Multivariate Modeling
DOI: 10.6084/m9.figshare.30105213
title: Functional role of <i>FvMdm10</i> in stress response, pathogenicity, and fumonisins production in <i>fusarium verticillioides</i>

description: Endoplasmic reticulum-mitochondrial encounter structure (ERMES), the protein complex that tethers mitochondria and endoplasmic reticulum, is critical for mitochondrial functions and various cellular processes. Our preliminary studies showed that mitochondrial integrity was critical for fumonisin biosynthesis. However, the biological roles of ERMES and its subunits in phytopathogenic fungi, especially their roles in the regulation of fumonisin biosynthesis remain ambiguous. In this current study, we investigated the biological functions of FvMdm10, the core component of ERMES, in the fumonisin-producing fungus <i>Fusarium verticillioides</i>. The gene-deletion mutant ΔFvMdm10 exhibited attenuated virulence on intact maize kernels compared with the wild-type strain M3125, which partially attributed to impaired vegetative growth and conidia germination. In addition, ΔFvMdm10 became more resistant to QoIs when compared to M3125. Furthermore, we observed anomalous vacuole morphology in ΔFvMdm10, subsequently leading to decreased FB<sub>1</sub> production. Noticeably, ∆FvMdm10 takes advantage of accumulated lipid droplets to overcome the oxidative stress generated by H<sub>2</sub>O<sub>2</sub>. Taken together, our results showed that <i>FvMdm10</i> is critical for fungal development, stress response, lipid biogenesis and fumonisins biosynthesis in the toxigenic fungus <i>F. verticillioides</i>.
DOI: 10.6084/m9.figshare.30105213.v1
title: Functional role of <i>FvMdm10</i> in stress response, pathogenicity, and fumonisins production in <i>fusarium verticillioides</i>

description: Endoplasmic reticulum-mitochondrial encounter structure (ERMES), the protein complex that tethers mitochondria and endoplasmic reticulum, is critical for mitochondrial functions and various cellular processes. Our preliminary studies showed that mitochondrial integrity was critical for fumonisin biosynthesis. However, the biological roles of ERMES and its subunits in phytopathogenic fungi, especially their roles in the regulation of fumonisin biosynthesis remain ambiguous. In this current study, we investigated the biological functions of FvMdm10, the core component of ERMES, in the fumonisin-producing fungus <i>Fusarium verticillioides</i>. The gene-deletion mutant ΔFvMdm10 exhibited attenuated virulence on intact maize kernels compared with the wild-type strain M3125, which partially attributed to impaired vegetative growth and conidia germination. In addition, ΔFvMdm10 became more resistant to QoIs when compared to M3125. Furthermore, we observed anomalous vacuole morphology in ΔFvMdm10, subsequently leading to decreased FB<sub>1</sub> production. Noticeably, ∆FvMdm10 takes advantage of accumulated lipid droplets to overcome the oxidative stress generated by H<sub>2</sub>O<sub>2</sub>. Taken together, our results showed that <i>FvMdm10</i> is critical for fungal development, stress response, lipid biogenesis and fumonisins biosynthesis in the toxigenic fungus <i>F. verticillioides</i>.
DOI: 10.6084/m9.figshare.30556725.v1
title: Unraveling the immunosuppressive role of Elastase B produced by cystic fibrosis isolates of <i>Pseudomonas aeruginosa</i> in an organotypic 3D lung epithelial cell model

description: <i>Pseudomonas aeruginosa</i> chronically infects the lungs of people with cystic fibrosis (pwCF), where it produces a broad range of proteases that impact host immunity and inflammation. While some studies suggest these enzymes induce inflammation and may contribute to the excessive inflammatory response in pwCF, others indicate that they degrade cytokines and suppress the immune response. Here, we investigate the role of <i>P. aeruginosa</i> proteases in CF lung inflammation by culturing clinical isolates under physiologically relevant conditions and studying the inflammatory response in an organotypic 3D lung cell culture model. Exposure to supernatants from isolates with proteolytic activity led to cytokine degradation and reduced cytokine release in the 3D model. To identify the specific protease(s) responsible, we performed a proteomics analysis on the supernatants of the isolates with and without proteolytic activity. In total, 79 proteases were identified in the supernatants, with extracellular proteases among the most differentially expressed in the proteolytically active isolate group. Metalloprotease Elastase B (LasB) exhibited the highest level of differential expression. Therefore, we determined the contribution of LasB to the observed reduction in cytokine levels by utilizing <i>P. aeruginosa lasB</i> knockout mutants. Compared to the <i>lasB</i> mutant, the wild-type strain significantly decreased inflammation by degrading MCP-1, IL-1β, GM-CSF, and IL-8. While this study brings to light a key role for LasB, our findings demonstrate that immunomodulation by <i>P. aeruginosa</i> most likely involves the combined action of multiple proteases. This study provides a foundation for future research into protease-mediated immune evasion during chronic infection.
DOI: 10.6084/m9.figshare.30007340
title: The ABC type fucose operon regulated by XtrSs through CcpA contributes to <i>Streptococcus suis</i> survival in macrophages

description: <i>Streptococcus suis</i> (<i>S. suis</i>), an important zoonotic pathogen, poses a huge threat to the pig industry and human health. The fucose operon (FCS) is found in many bacteria that utilize host glycosylation modifications, contributing to bacterial growth and infection. We previously discovered that the virulence associated streptococcal transcriptional regulator XtrSs could downregulate FCS transcription. In this study, the FCSs of <i>S. suis</i> were classified into ABC and PTS types, and XtrSs indirectly repressed ABC type FCS transcription. Importantly, we found that Catabolite control protein A (CcpA) was the intermediate regulator of XtrSs, but not the FCS upstream regulator FcsR, directly repressing ABC type FCS transcription by binding to a novel Cre site. Interestingly, although ABC type FCS responded to fucose, <i>S. suis</i> failed to proliferate in media with fucose as the sole carbon source. Notably, FCS mutant treated macrophages exhibited decreased fucosyltransferases transcription and impaired AMPK/mTOR signaling to a certain extent, which resulted in increased autophagy processes and ultimately decreasing <i>S. suis</i> survival in macrophages. In conclusion, our findings first confirmed the detailed regulatory mechanism of ABC type FCS and revealed that FCS contributed to the intramacrophage survival of <i>S. suis</i> by inhibiting autophagy processes.
DOI: 10.6084/m9.figshare.30007340.v2
title: The ABC type fucose operon regulated by XtrSs through CcpA contributes to <i>Streptococcus suis</i> survival in macrophages

description: <i>Streptococcus suis</i> (<i>S. suis</i>), an important zoonotic pathogen, poses a huge threat to the pig industry and human health. The fucose operon (FCS) is found in many bacteria that utilize host glycosylation modifications, contributing to bacterial growth and infection. We previously discovered that the virulence associated streptococcal transcriptional regulator XtrSs could downregulate FCS transcription. In this study, the FCSs of <i>S. suis</i> were classified into ABC and PTS types, and XtrSs indirectly repressed ABC type FCS transcription. Importantly, we found that Catabolite control protein A (CcpA) was the intermediate regulator of XtrSs, but not the FCS upstream regulator FcsR, directly repressing ABC type FCS transcription by binding to a novel Cre site. Interestingly, although ABC type FCS responded to fucose, <i>S. suis</i> failed to proliferate in media with fucose as the sole carbon source. Notably, FCS mutant treated macrophages exhibited decreased fucosyltransferases transcription and impaired AMPK/mTOR signaling to a certain extent, which resulted in increased autophagy processes and ultimately decreasing <i>S. suis</i> survival in macrophages. In conclusion, our findings first confirmed the detailed regulatory mechanism of ABC type FCS and revealed that FCS contributed to the intramacrophage survival of <i>S. suis</i> by inhibiting autophagy processes.
DOI: 10.6084/m9.figshare.30657245
title: Oral L-Arginine treatment attenuates <i>Cryptococcus neoformans</i> extrapulmonary dissemination and disease progression

description: <i>Cryptococcus neoformans</i> is an opportunistic fungal pathogen causing severe infections in immunocompromised individuals. Arginine metabolism is critical for immune regulation, but its precise role in cryptococcal pathogenesis is not well understood. In this study, we investigated systemic and tissue-specific alterations in L-arginine metabolism during pulmonary <i>C. neoformans</i> infection and evaluated L-arginine supplementation as a potential therapy using a murine model. Key assessments included fungal burden quantification, inflammatory cell and cytokine characterization, brain gene expression analysis, histological examinations, and survival studies. We found significant depletion of serum L-arginine and its downstream metabolites, accompanied by increased arginase activity in infected tissues, indicating a disrupted metabolic balance. Gene expression analysis showed distinct metabolic shifts, including upregulation of arginase-1 (Arg1) and proline metabolism genes, with concurrent suppression of nitric oxide synthase 2 (Nos2) in the brain during the late infection phase. Oral L-arginine supplementation significantly reduced fungal burdens in the brain and spleen, suggesting its effectiveness in controlling cryptococcal dissemination from the lungs. Consequently, L-arginine administration improved survival and clinical scores while also reducing brain cryptococcoma in infected mice. Mechanistically, L-arginine enhanced protective immune responses within the mouse brain, facilitated microglial-mediated clearance of <i>Cryptococcus</i>, and reduced cryptococcal invasion across brain endothelial cells <i>in vitro</i>. In summary, oral administration of L-arginine mitigates <i>C. neoformans</i> dissemination by augmenting brain’s immune response. This study provides crucial insights into arginine metabolism in cryptococcal disease progression, supporting L-arginine as a promising immunomodulatory therapy.
DOI: 10.6084/m9.figshare.30657245.v1
title: Oral L-Arginine treatment attenuates <i>Cryptococcus neoformans</i> extrapulmonary dissemination and disease progression

description: <i>Cryptococcus neoformans</i> is an opportunistic fungal pathogen causing severe infections in immunocompromised individuals. Arginine metabolism is critical for immune regulation, but its precise role in cryptococcal pathogenesis is not well understood. In this study, we investigated systemic and tissue-specific alterations in L-arginine metabolism during pulmonary <i>C. neoformans</i> infection and evaluated L-arginine supplementation as a potential therapy using a murine model. Key assessments included fungal burden quantification, inflammatory cell and cytokine characterization, brain gene expression analysis, histological examinations, and survival studies. We found significant depletion of serum L-arginine and its downstream metabolites, accompanied by increased arginase activity in infected tissues, indicating a disrupted metabolic balance. Gene expression analysis showed distinct metabolic shifts, including upregulation of arginase-1 (Arg1) and proline metabolism genes, with concurrent suppression of nitric oxide synthase 2 (Nos2) in the brain during the late infection phase. Oral L-arginine supplementation significantly reduced fungal burdens in the brain and spleen, suggesting its effectiveness in controlling cryptococcal dissemination from the lungs. Consequently, L-arginine administration improved survival and clinical scores while also reducing brain cryptococcoma in infected mice. Mechanistically, L-arginine enhanced protective immune responses within the mouse brain, facilitated microglial-mediated clearance of <i>Cryptococcus</i>, and reduced cryptococcal invasion across brain endothelial cells <i>in vitro</i>. In summary, oral administration of L-arginine mitigates <i>C. neoformans</i> dissemination by augmenting brain’s immune response. This study provides crucial insights into arginine metabolism in cryptococcal disease progression, supporting L-arginine as a promising immunomodulatory therapy.
DOI: 10.6084/m9.figshare.29266811
title: Comparative omics analysis of the impact of <i>Mycoplasma synoviae</i> infection on the immune mechanisms of poultry spleen

description: <i>Mycoplasma synoviae</i> (MS) infection can cause severe inflammatory responses in avian species, evading immune recognition, leading to chronic infection and immune dysfunction. Although the pathogenic mechanisms and immune evasion strategies of MS have not been fully elucidated, the crucial role of the spleen in immune responses cannot be overlooked. Building on preliminary findings related to the tissue damage and inflammatory responses in chicken spleens caused by MS infection, this study further utilizes transcriptomic and proteomic technologies to thoroughly investigate the comprehensive effects of MS infection on the chicken spleen. We detected 946 differentially expressed genes (DEGs) and 305 differentially expressed proteins (DEPs) during MS infection, including 771 up-regulated and 175 down-regulated DEGs, along with 145 up-regulated and 160 down-regulated DEPs. Gene Ontology (GO) analysis indicated that the DEGs/DEPs are enriched in processes related to immune activation, antioxidation/cell apoptosis, inflammation, and endoplasmic reticulum protein processing. KEGG pathway enrichment analysis revealed immune-related pathways closely associated with MS infection, particularly in endoplasmic reticulum protein processing, cytokine-cytokine receptor interaction, and the myosin light chain kinase (MAPK) signalling pathway. Suggesting that the activation and interaction of these pathways may play a critical role in the immune response during MS infection. Overall, this study, for the first time, employs RNA-Seq and TMT quantitative proteomics to comprehensively analyse the interaction mechanisms between MS and chicken spleen, enhancing our understanding of the complexity of the immune mechanisms induced by MS. This provides valuable insights for future research and intervention strategies targeting MS infection.
DOI: 10.6084/m9.figshare.29266811.v1
title: Comparative omics analysis of the impact of <i>Mycoplasma synoviae</i> infection on the immune mechanisms of poultry spleen

description: <i>Mycoplasma synoviae</i> (MS) infection can cause severe inflammatory responses in avian species, evading immune recognition, leading to chronic infection and immune dysfunction. Although the pathogenic mechanisms and immune evasion strategies of MS have not been fully elucidated, the crucial role of the spleen in immune responses cannot be overlooked. Building on preliminary findings related to the tissue damage and inflammatory responses in chicken spleens caused by MS infection, this study further utilizes transcriptomic and proteomic technologies to thoroughly investigate the comprehensive effects of MS infection on the chicken spleen. We detected 946 differentially expressed genes (DEGs) and 305 differentially expressed proteins (DEPs) during MS infection, including 771 up-regulated and 175 down-regulated DEGs, along with 145 up-regulated and 160 down-regulated DEPs. Gene Ontology (GO) analysis indicated that the DEGs/DEPs are enriched in processes related to immune activation, antioxidation/cell apoptosis, inflammation, and endoplasmic reticulum protein processing. KEGG pathway enrichment analysis revealed immune-related pathways closely associated with MS infection, particularly in endoplasmic reticulum protein processing, cytokine-cytokine receptor interaction, and the myosin light chain kinase (MAPK) signalling pathway. Suggesting that the activation and interaction of these pathways may play a critical role in the immune response during MS infection. Overall, this study, for the first time, employs RNA-Seq and TMT quantitative proteomics to comprehensively analyse the interaction mechanisms between MS and chicken spleen, enhancing our understanding of the complexity of the immune mechanisms induced by MS. This provides valuable insights for future research and intervention strategies targeting MS infection.