cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.5281/zenodo.10246086
title: Dataset related to article "SUOH 03 Guidewire for the Management of Coronary Artery Dissection: Insights from a Multicenter Registry"

description: This record contains raw data related to article "SUOH 03 Guidewire for the Management of Coronary Artery Dissection: Insights from a Multicenter Registry"
Abstract
Background: In the setting of coronary artery dissection, both spontaneous and iatrogenic, fixing the intimal tear, usually with stent implantation, can be extremely challenging if the distal wire position has been lost. Common complications are mainly related to the inadvertent subintimal tracking of the guidewire while attempting to gain the distal true lumen.
Aims: To report the registry results of using the SUOH 0.3 guidewire for managing coronary artery dissection in a real-world multicenter setting.
Methods: The study population in this retrospective, multicenter, international registry included 75 consecutive patients who underwent PCI and required an antegrade wiring of a dissected coronary artery.
Results: Successful use of SUOH 0.3 was achieved in 69 (92%) patients. The use of a microcatheter was associated with a significantly higher rate of TIMI 3 flow at the end of the procedure (no microcatheter: n = 17, 81%; microcatheter: n = 52, 96.3%; p = 0.017). The first recanalization attempt was made with the SUOH 03 guidewire in 48 (64%) cases, and it was successful in 42 (87%). The overall PCI success rate was reported in 72 (96%) patients, with no significant differences among patients with different origins, mechanisms, and locations of dissection.
Conclusions: In this setting, the SUOH 0.3 guidewire provides high procedural success without additional complex techniques.
DOI: 10.5517/ccdc.csd.cc28n9z7
title: CCDC 2104899: Experimental Crystal Structure Determination

description: Related Article: Jason Holland, Ruoming Tian, Mohan Bhadbhade, John Arron Stride|2023|CSD Communication|||
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5281/zenodo.10246085
title: Dataset related to article "SUOH 03 Guidewire for the Management of Coronary Artery Dissection: Insights from a Multicenter Registry"

description: This record contains raw data related to article "SUOH 03 Guidewire for the Management of Coronary Artery Dissection: Insights from a Multicenter Registry"
Abstract
Background: In the setting of coronary artery dissection, both spontaneous and iatrogenic, fixing the intimal tear, usually with stent implantation, can be extremely challenging if the distal wire position has been lost. Common complications are mainly related to the inadvertent subintimal tracking of the guidewire while attempting to gain the distal true lumen.
Aims: To report the registry results of using the SUOH 0.3 guidewire for managing coronary artery dissection in a real-world multicenter setting.
Methods: The study population in this retrospective, multicenter, international registry included 75 consecutive patients who underwent PCI and required an antegrade wiring of a dissected coronary artery.
Results: Successful use of SUOH 0.3 was achieved in 69 (92%) patients. The use of a microcatheter was associated with a significantly higher rate of TIMI 3 flow at the end of the procedure (no microcatheter: n = 17, 81%; microcatheter: n = 52, 96.3%; p = 0.017). The first recanalization attempt was made with the SUOH 03 guidewire in 48 (64%) cases, and it was successful in 42 (87%). The overall PCI success rate was reported in 72 (96%) patients, with no significant differences among patients with different origins, mechanisms, and locations of dissection.
Conclusions: In this setting, the SUOH 0.3 guidewire provides high procedural success without additional complex techniques.
DOI: 10.5517/ccdc.csd.cc2hlbgx
title: CCDC 2311529: Experimental Crystal Structure Determination

description: Related Article: Jason Holland, Ruoming Tian, Mohan Bhadbhade, John Arron Stride|2023|CSD Communication|||
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc28nb09
title: CCDC 2104900: Experimental Crystal Structure Determination

description: Related Article: Jason Holland, Ruoming Tian, Mohan Bhadbhade, John Arron Stride|2023|CSD Communication|||
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc28nb1b
title: CCDC 2104901: Experimental Crystal Structure Determination

description: Related Article: Jason Holland, Ruoming Tian, Mohan Bhadbhade, John Arron Stride|2023|CSD Communication|||
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc28nb2c
title: CCDC 2104902: Experimental Crystal Structure Determination

description: Related Article: Jason Holland, Ruoming Tian, Mohan Bhadbhade, John Arron Stride|2023|CSD Communication|||
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2hl7v6
title: CCDC 2311448: Experimental Crystal Structure Determination

description: Related Article: Jason Holland, John Arron Stride, Mohan Bhadbhade, Ruoming Tian|2023|CSD Communication|||
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5281/zenodo.7533472
title: Dataset related to article: "Time-dependent effect of GLP-1 receptor agonists on cardiovascular benefits: a real-world study"

description: This record contains data related to article "Time-dependent effect of GLP-1 receptor agonists on cardiovascular benefits: a real-world study" 
Background: Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) have shown cardiovascular benefits in cardiovascular outcome trials in type 2 diabetes mellitus. However, the most convincing evidence was obtained in subjects with established cardiovascular (CV) disease. We analyzed the determinants of GLP-1 RA-mediated CV protection in a real-world population of persons with type 2 diabetes with and without a history of CV events with long-term follow-up.
Methods: Retrospective cohort study of 550 individuals with type 2 diabetes (395 in primary CV prevention, 155 in secondary CV prevention), followed at a single center after the first prescription of a GLP-1 RA between 2009 and 2019. CV and metabolic outcomes were assessed.
Results: Median duration of follow-up was 5.0 years (0.25-10.8) in primary prevention and 3.6 years (0-10.3) in secondary prevention, with a median duration of treatment of 3.2 years (0-10.8) and 2.5 years (0-10.3) respectively. In the multivariable Cox regression model considering GLP-1 RA treatment as a time-dependent covariate, in the primary prevention group, changes in BMI and glycated hemoglobin did not have an impact on MACE risk, while age at the time of GLP-1 initiation (HR 1.08, 95% CI 1.03-1.14, p = 0.001) and GLP-1 RA cessation by time (HR 3.40, 95% CI 1.82-6.32, p < 0.001) increased the risk of MACE. Regarding the secondary prevention group, only GLP-1 RA cessation by time (HR 2.71, 95% CI 1.46-5.01, p = 0.002) increased the risk of MACE. With respect to those who withdrew treatment, subjects who continued the GLP-1 RA had significantly greater weight loss and lower glycated hemoglobin levels during follow-up.
Conclusions: In this real-world type 2 diabetes population, discontinuation of GLP-1 RA treatment was associated to a higher risk of major cardiovascular events, in both subjects with and without a history of CV events.
DOI: 10.5281/zenodo.7533471
title: Dataset related to article: "Time-dependent effect of GLP-1 receptor agonists on cardiovascular benefits: a real-world study"

description: This record contains data related to article "Time-dependent effect of GLP-1 receptor agonists on cardiovascular benefits: a real-world study" 
Background: Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) have shown cardiovascular benefits in cardiovascular outcome trials in type 2 diabetes mellitus. However, the most convincing evidence was obtained in subjects with established cardiovascular (CV) disease. We analyzed the determinants of GLP-1 RA-mediated CV protection in a real-world population of persons with type 2 diabetes with and without a history of CV events with long-term follow-up.
Methods: Retrospective cohort study of 550 individuals with type 2 diabetes (395 in primary CV prevention, 155 in secondary CV prevention), followed at a single center after the first prescription of a GLP-1 RA between 2009 and 2019. CV and metabolic outcomes were assessed.
Results: Median duration of follow-up was 5.0 years (0.25-10.8) in primary prevention and 3.6 years (0-10.3) in secondary prevention, with a median duration of treatment of 3.2 years (0-10.8) and 2.5 years (0-10.3) respectively. In the multivariable Cox regression model considering GLP-1 RA treatment as a time-dependent covariate, in the primary prevention group, changes in BMI and glycated hemoglobin did not have an impact on MACE risk, while age at the time of GLP-1 initiation (HR 1.08, 95% CI 1.03-1.14, p = 0.001) and GLP-1 RA cessation by time (HR 3.40, 95% CI 1.82-6.32, p < 0.001) increased the risk of MACE. Regarding the secondary prevention group, only GLP-1 RA cessation by time (HR 2.71, 95% CI 1.46-5.01, p = 0.002) increased the risk of MACE. With respect to those who withdrew treatment, subjects who continued the GLP-1 RA had significantly greater weight loss and lower glycated hemoglobin levels during follow-up.
Conclusions: In this real-world type 2 diabetes population, discontinuation of GLP-1 RA treatment was associated to a higher risk of major cardiovascular events, in both subjects with and without a history of CV events.
DOI: 10.6084/m9.figshare.24712096.v1
title: Table of available depth data statistics for the N=25 group north trajectories from Uncovering loggerhead (<i>Caretta caretta</i>) navigation strategy in the open ocean through the consideration of their diving behaviour

description: First section of the table (outlines in blue): statistics for the open ocean section of the N=25 tracks from Deployement date to reached coast date with the 4 largest data gaps provided (gaps#,date#). The second section of the table (outlines in red) provide the selected track sections which limit the impact of data gaps below &lt; 48hours by truncating either at the beginning or the end (highlighted green lines). The orange highlighted lines are those which could not be reasonnalby truncated and for which either the percentage of gaps or the max gaps time are respectively greater then 20% and 48hours.
DOI: 10.6084/m9.figshare.24712096
title: Table of available depth data statistics for the N=25 group north trajectories from Uncovering loggerhead (<i>Caretta caretta</i>) navigation strategy in the open ocean through the consideration of their diving behaviour

description: First section of the table (outlines in blue): statistics for the open ocean section of the N=25 tracks from Deployement date to reached coast date with the 4 largest data gaps provided (gaps#,date#). The second section of the table (outlines in red) provide the selected track sections which limit the impact of data gaps below &lt; 48hours by truncating either at the beginning or the end (highlighted green lines). The orange highlighted lines are those which could not be reasonnalby truncated and for which either the percentage of gaps or the max gaps time are respectively greater then 20% and 48hours.
DOI: 10.6084/m9.figshare.24712005
title: RUNX1 methylation-Thyroid cancer.sav

description: <b>目的：</b> 在活检不确定的情况下，准确识别甲状腺结节的恶性肿瘤仍然是一个挑战。，甲状腺状癌 （PTC） 的异常 DNA 甲基化特征（良性甲状腺结节 （BTN） 相比 <b>方法：</b> 采用850K阵列和RNA测序对早期PTC和BTN组织样本进行基因组分析。鉴定出的基因在两项使用质谱法的独立病例对照研究中得到了验证。<b>结果：</b> 的低甲基化 PTC 中 RUNX1 （所有 OR ≥ 1.50）。RUNX1化取得了良好的准确性，在区分正在 早期PTC和BTN <b>结论</b><b>s</b><b>：</b> 我们揭示了 之间的 运行X1 与PTC表明RUNX1甲基化是伴随诊断甲状腺结节恶性结节的潜在生物标志物。
DOI: 10.6084/m9.figshare.24712005.v1
title: RUNX1 methylation-Thyroid cancer.sav

description: <b>目的：</b> 在活检不确定的情况下，准确识别甲状腺结节的恶性肿瘤仍然是一个挑战。，甲状腺状癌 （PTC） 的异常 DNA 甲基化特征（良性甲状腺结节 （BTN） 相比 <b>方法：</b> 采用850K阵列和RNA测序对早期PTC和BTN组织样本进行基因组分析。鉴定出的基因在两项使用质谱法的独立病例对照研究中得到了验证。<b>结果：</b> 的低甲基化 PTC 中 RUNX1 （所有 OR ≥ 1.50）。RUNX1化取得了良好的准确性，在区分正在 早期PTC和BTN <b>结论</b><b>s</b><b>：</b> 我们揭示了 之间的 运行X1 与PTC表明RUNX1甲基化是伴随诊断甲状腺结节恶性结节的潜在生物标志物。
DOI: 10.48670/moi-00001
title: Arctic Ocean Physics Analysis and Forecast
DOI: 10.48670/moi-00025
title: Atlantic-Iberian Biscay Irish- Ocean Wave Analysis and Forecast
DOI: 10.5281/zenodo.10246151
title: Dataset related to article "Comparison of Long-Term Oncological Results in Young Women with Breast Cancer between BRCA-Mutation Carriers Versus Non-Carriers: How Tumor and Genetic Risk Factors Influence the Clinical Prognosis"

description: This record contains raw data related to article "Comparison of Long-Term Oncological Results in Young Women with Breast Cancer between BRCA-Mutation Carriers Versus Non-Carriers: How Tumor and Genetic Risk Factors Influence the Clinical Prognosis"
Abstract
Background: Breast cancer (BC) is very uncommon in young women (YW) and it is unclear whether a BRCA mutation has prognostic implications. Our aim was to evaluate the characteristics of YW with BC by comparing the long-term oncological results between BRCA-mutation carriers and non-carriers.
Methods: We retrospectively reviewed all the consecutive YW (aged 18-40 years) diagnosed with BC. Endpoints were disease-free survival (DFS), distant disease-free survival (DDFS), and overall survival (OS).
Results: 63 YW with a BRCA mutation were compared with 339 YW without BRCA mutation. BRCA-mutation carriers were younger (60.3% versus 34.8% if age ≤ 35 years, p = 0.001) and presented with more aggressive tumors (66.7% versus 40.7% if G3, p = 0.001; 57.2% versus 12.4% if biological subtype triple-negative, p = 0.001; 73.0% versus 39.2% if Ki67 ≥ 25%, p = 0.001). Non-carriers presented significantly better DFS, DDFS, and OS compared with BRCA-mutation carriers. Neoadjuvant chemotherapy was found to be an independent protective factor for OS in BRCA-mutation carriers.
Conclusions: BC is more likely to present at a younger age (≤ 35 years) and with more aggressive characteristics (G3, triple-negative, Ki67 ≥ 25%) in YW with BRCA mutation compared with their non-mutated counterparts. Young BRCA-mutation carriers showed a poorer prognosis in terms of recurrence and survival compared with non-carriers. The implementation of neoadjuvant chemotherapy may improve survival in YW with BC and BRCA mutation.
DOI: 10.5281/zenodo.10246152
title: Dataset related to article "Comparison of Long-Term Oncological Results in Young Women with Breast Cancer between BRCA-Mutation Carriers Versus Non-Carriers: How Tumor and Genetic Risk Factors Influence the Clinical Prognosis"

description: This record contains raw data related to article "Comparison of Long-Term Oncological Results in Young Women with Breast Cancer between BRCA-Mutation Carriers Versus Non-Carriers: How Tumor and Genetic Risk Factors Influence the Clinical Prognosis"
Abstract
Background: Breast cancer (BC) is very uncommon in young women (YW) and it is unclear whether a BRCA mutation has prognostic implications. Our aim was to evaluate the characteristics of YW with BC by comparing the long-term oncological results between BRCA-mutation carriers and non-carriers.
Methods: We retrospectively reviewed all the consecutive YW (aged 18-40 years) diagnosed with BC. Endpoints were disease-free survival (DFS), distant disease-free survival (DDFS), and overall survival (OS).
Results: 63 YW with a BRCA mutation were compared with 339 YW without BRCA mutation. BRCA-mutation carriers were younger (60.3% versus 34.8% if age ≤ 35 years, p = 0.001) and presented with more aggressive tumors (66.7% versus 40.7% if G3, p = 0.001; 57.2% versus 12.4% if biological subtype triple-negative, p = 0.001; 73.0% versus 39.2% if Ki67 ≥ 25%, p = 0.001). Non-carriers presented significantly better DFS, DDFS, and OS compared with BRCA-mutation carriers. Neoadjuvant chemotherapy was found to be an independent protective factor for OS in BRCA-mutation carriers.
Conclusions: BC is more likely to present at a younger age (≤ 35 years) and with more aggressive characteristics (G3, triple-negative, Ki67 ≥ 25%) in YW with BRCA mutation compared with their non-mutated counterparts. Young BRCA-mutation carriers showed a poorer prognosis in terms of recurrence and survival compared with non-carriers. The implementation of neoadjuvant chemotherapy may improve survival in YW with BC and BRCA mutation.
DOI: 10.48670/moi-00055
title: Atlantic - European North West Shelf - Ocean Wave Analysis and Forecast
DOI: 10.48670/moi-00301
title: Black Sea, Bio-Geo-Chemical, L3, daily Satellite Observations (Near Real Time)
DOI: 10.48670/moi-00302
title: Black Sea, Bio-Geo-Chemical, L4, monthly means, daily gapfree and climatology Satellite Observations (Near Real Time)
DOI: 10.48670/moi-00303
title: Black Sea, Bio-Geo-Chemical, L3, daily Satellite Observations (1997-ongoing)
DOI: 10.48670/moi-00304
title: Black Sea, Bio-Geo-Chemical, L4, monthly means, daily gapfree and climatology Satellite Observations (1997-ongoing)
DOI: 10.48670/moi-00297
title: Mediterranean Sea, Bio-Geo-Chemical, L3, daily Satellite Observations (Near Real Time)
DOI: 10.48670/moi-00298
title: Mediterranean Sea, Bio-Geo-Chemical, L4, monthly means, daily gapfree and climatology Satellite Observations (Near Real Time)
DOI: 10.6084/m9.figshare.17134802
title: Confidence intervals for the parameter of the scaled-uniform model

description: The scaled-uniform model has been lately considered to illustrate problems in frequentist point estimation arising when the minimal sufficient statistic is not complete. Here we consider the problem of interval estimation and derive pivotal quantities based on a series of point estimators proposed in the literature. We compare the resulting intervals of given confidence level in terms of expected lengths. Pivotal quantities, confidence intervals and expected lengths are all computed using simulations implemented with R (code is available). Numerical results suggest that the maximum likelihood estimator, regardless of its inefficiency, yields confidence intervals that outperform the other available sets of the same level.
DOI: 10.6084/m9.figshare.17134802.v2
title: Confidence intervals for the parameter of the scaled-uniform model

description: The scaled-uniform model has been lately considered to illustrate problems in frequentist point estimation arising when the minimal sufficient statistic is not complete. Here we consider the problem of interval estimation and derive pivotal quantities based on a series of point estimators proposed in the literature. We compare the resulting intervals of given confidence level in terms of expected lengths. Pivotal quantities, confidence intervals and expected lengths are all computed using simulations implemented with R (code is available). Numerical results suggest that the maximum likelihood estimator, regardless of its inefficiency, yields confidence intervals that outperform the other available sets of the same level.
DOI: 10.6084/m9.figshare.17081554.v1
title: Using biomarkers to allocate patients in a response-adaptive clinical trial

description: In this paper, we discuss a response adaptive randomization method, and why it should be used in clinical trials for rare diseases compared to a randomized controlled trial with equal fixed randomization. The developed method uses a patient’s biomarkers to alter the allocation probability to each treatment, in order to emphasize the benefit to the trial population. The method starts with an initial burn-in period of a small number of patients, who with equal probability, are allocated to each treatment. We then use a regression method to predict the best outcome of the next patient, using their biomarkers and the information from the previous patients. This estimated best treatment is assigned to the next patient with high probability. A completed clinical trial for the effect of catumaxomab on the survival of cancer patients is used as an example to demonstrate the use of the method and the differences to a controlled trial with equal allocation. Different regression procedures are investigated and compared to a randomized controlled trial, using efficacy and ethical measures.
DOI: 10.48670/moi-00300
title: Mediterranean Sea, Bio-Geo-Chemical, L4, monthly means, daily gapfree and climatology Satellite Observations (1997-ongoing)
DOI: 10.3886/e195482
title: The Last Free Traders? Interwar Trade Policy in the Netherlands and Netherlands East Indies

description: There has still been too little detailed work on the protectionism that emerged in the wake of the Great Depression. In this paper we explore the experiences of two countries that have been largely neglected in the literature, the Netherlands and Netherlands East Indies (NEI). How did these traditionally free-trading economies respond to the Depression? We construct a detailed product-level database of tariff and non-tariff barriers to trade based on primary sources. While ad valorem tariff increases in the Netherlands were largely due to deflation, the country protected agriculture and textiles in a number of ways. Once quotas are taken into account, trade restrictiveness indices suggest that protection in the Netherlands and NEI was comparable to protection in the UK and India respectively. The NEI quota system was largely geared to protecting Dutch exporters, and succeeded in doing so, but the reverse was not true.