DOI: 10.5061/dryad.v15dv429v
title: Data from: Minimal evidence of inflammaging in naturalistic chimpanzee populations

description: Objectives: Whereas chronic inflammation is a hallmark of aging in many
 human populations, inflammaging is reduced in groups characterized by
 frequent physical activity and diets low in processed foods. Since most
 biomarkers of inflammation require blood sampling, comparative data from
 our closest primate relatives have been derived from sedentary, captive
 primate populations, whose processed diets are uncharacteristic of the
 wild. Materials and Methods: We evaluated ageing profiles of inflammation
 and oxidative stress biomarkers derived from urine and serum samples in
 semi-free ranging chimpanzees (Pan troglodytes) living in two African
 sanctuaries (N=156 health checks, 73 individuals, ages 11-39 years), where
 diet and physical activity more closely approximate the wild condition
 than captive laboratory settings. We compared these to urinary markers
 from wild chimpanzees from Kanyawara, Kibale National Park, Uganda
 (N=1,849 time points, 50 individuals, ages 10-57 years), as well as
 published serum data from biomedical laboratories. Results: Serum
 inflammatory biomarker (CRP and IL6) levels in sanctuary chimpanzees were
 2-10 times lower on average than those of laboratory chimpanzees. Compared
 to wild populations, acute immune activity (neopterin) and lipid
 peroxidation (isoprostanes) were higher in sanctuaries, while chronic
 systemic inflammation (suPAR) and DNA damage (OHdG) did not differ. We
 detected a significant but modest age-related increase in one biomarker
 (suPAR) in the wild sample. Discussion: These results parallel recent
 findings from humans in demonstrating that chronic inflammation is not a
 natural consequence of aging but may rather be driven by environmental
 contexts that are mismatched to the evolutionary history of a given
 species.
description: See paper for all detailed methods for this dataset.
description: # Data from: Minimal evidence of inflammaging in naturalistic chimpanzee
 populations Dataset DOI:
 [10.5061/dryad.v15dv429v](https://doi.org/10.5061/dryad.v15dv429v) ##
 Description of the data and file structure This data set consists of one
 data file (.xlsx format) reporting urinary and/or serum markers of
 inflammation from sanctuary-living and wild chimpanzees, as reported in
 the associated manuscript. There is a key tab in the file defining each
 variable reported in the main data tab, also reported below. ### Files and
 variables #### File: DATA_Cole_etal_chimpanzee_inflammation.xlsx
 **Description:** urinary and serum markers of inflammation from
 chimpanzees. ##### Variables | ***Variable*** | ***Description*** | |
 :------------- |
 :-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- | | Subject | Unique chimpanzee identifier | | Sex | Male or female | | Facility | Sanctuary or wild | | Site | Ngamba, Tchimpounga, or Kanyawara | | SiteYear | Site and year  | | Age | Age (years) at time of sampling | | TimeUrine | Time of urine sampling | | AssayYear | Year of assay | | uNeo | Urinary neopterin. Values &lt; 250 nmol/L assigned 250. nmol/L; values over 4375 nmol/L assigned 4375 nmol/L. Results are corrected for specific gravity and log transformed. Blank cells indicate no assay result or exclusion due to assay error | | usuPAR | Urinary soluble urokinase plasminogen activator receptor. Values &lt; 75 pg/mL assigned 75 pg/mL; values over 20000 pg/mL assigned 20000 pg/mL. Results are corrected for specific gravity and log transformed. Blank cells indicate no assay result or exclusion due to assay error | | uIsop | Urinary isoprostanes. Values &lt; 0.2 ng/mL assigned 0.2 ng/mL; values over 400 ng/mL assigned 400 ng/mL. Results are corrected for specific gravity and log transformed. Blank cells indicate no assay result or exclusion due to assay error | | uOHdG | Urinary deoxyguanosine. Values &lt; 0.5 ng/mL assigned 0.5 ng/mL; values &gt; 200 ng/mL assigned 200 ng/mL. Results are corrected for specific gravity and log transformed. Blank cells indicate no assay result or exclusion due to assay error | | sCRP | Serum C-reactive protein. Results are log transformed. Blank cells indicate no assay result or exclusion due to spike or assay error | | sIL6 | Serum interleukin-6. Results are log transformed. Blank cells indicate no assay result or exclusion due to spike or assay error | #