cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.7867661.v1
title: Implementation of zero current switch turn-ON based buck-boost-buck type rectifier for low power applications

description: A single-stage single-switch AC–DC integrated converter is proposed in this paper, as a tight DC voltage regulator with unity input power factor for the fundamental component of the input current. Proposed converter is formed by the integration of buck-boost configuration with a buck converter operated by a single switch. The buck-boost section of the proposed configuration is operated in current discontinuous conduction mode (DCM) to get unity input power factor at the supply terminals and the buck section is operated up to boundary current conduction mode (BCM). The features acquired by the converter operating in complete discontinuous conduction mode (DCM) are unity input power factor, zero-current turn-ON for the Switch, fast and good DC output voltage regulation with extensive conversion range and low voltage stress on the switch. Additionally, the intermediate capacitor voltage stress is independent of converter load variations and so the switch also is subjected to constant peak voltage stress. A comprehensive study is carried out to obtain the necessary design equations. A design model is implemented using simulation and hardware. The results confirm the performance of the proposed configuration.
DOI: 10.6084/m9.figshare.7867565
title: Systematic review and network meta-analysis of approved medicines for the treatment of idiopathic pulmonary fibrosis

description: <b>Background:</b> Clinical practice guidelines for the treatment of idiopathic pulmonary fibrosis (IPF) currently recommend pirfenidone and nintedanib. However, there is a lack of evidence from head-to-head comparisons. <b>Objectives:</b> To perform a systematic review and network meta-analysis (NMA) to access the efficacy and tolerability of two new treatments for IPF, pirfenidone and nintedanib. <b>Methods</b>: Randomized controlled trials (RCTs) selection (CENTRAL, MEDLINE, Embase), data extraction, risk of bias analysis, and GRADE assessment were carried out by two authors separately. Direct estimates were calculated using standard pairwise meta-analysis. A Bayesian mixed treatment comparison approach for NMA estimates, with 95% confidence intervals (CI), was used to compare the treatments, calculating odds ratios (OR) and number needed to treat (NNTB) or harm (NNTH). <b>Results:</b> The NMA on 10 randomized controlled trials showed that each drug had a positive effect on percentage of forced vital capacity (FVC) decline ≥ 10% (pirfenidone OR = 0.54 [95% CI = 0.37–0.80], NNTB = 9 [95% CI = 7–22]; nintedanib OR = 0.59 [95% CI = 0.41–0.84], NNTB = 9 [95% CI = 6–23]), but no significant differences were noted when comparing pirfenidone and nintedanib with respect to acute exacerbations, mortality, and serious adverse events (FVC decline OR = 0.91 [95% CI = 0.45–2.03]) or dropouts (OR = 0.75 [95% CI = 0.33–1.27]). Nintedanib showed an effect on dropouts, OR = 1.61 (1.13–2.28) and NNTH = 14 (8–61). <b>Conclusions:</b> Based on RCTs of 12 month duration in patients with IPF, a positive effect on FVC decline was noted for both treatments and on dropouts for nintedanib, but no significant differences were noted between treatments.
DOI: 10.6084/m9.figshare.7867565.v2
title: Systematic review and network meta-analysis of approved medicines for the treatment of idiopathic pulmonary fibrosis

description: <b>Background:</b> Clinical practice guidelines for the treatment of idiopathic pulmonary fibrosis (IPF) currently recommend pirfenidone and nintedanib. However, there is a lack of evidence from head-to-head comparisons. <b>Objectives:</b> To perform a systematic review and network meta-analysis (NMA) to access the efficacy and tolerability of two new treatments for IPF, pirfenidone and nintedanib. <b>Methods</b>: Randomized controlled trials (RCTs) selection (CENTRAL, MEDLINE, Embase), data extraction, risk of bias analysis, and GRADE assessment were carried out by two authors separately. Direct estimates were calculated using standard pairwise meta-analysis. A Bayesian mixed treatment comparison approach for NMA estimates, with 95% confidence intervals (CI), was used to compare the treatments, calculating odds ratios (OR) and number needed to treat (NNTB) or harm (NNTH). <b>Results:</b> The NMA on 10 randomized controlled trials showed that each drug had a positive effect on percentage of forced vital capacity (FVC) decline ≥ 10% (pirfenidone OR = 0.54 [95% CI = 0.37–0.80], NNTB = 9 [95% CI = 7–22]; nintedanib OR = 0.59 [95% CI = 0.41–0.84], NNTB = 9 [95% CI = 6–23]), but no significant differences were noted when comparing pirfenidone and nintedanib with respect to acute exacerbations, mortality, and serious adverse events (FVC decline OR = 0.91 [95% CI = 0.45–2.03]) or dropouts (OR = 0.75 [95% CI = 0.33–1.27]). Nintedanib showed an effect on dropouts, OR = 1.61 (1.13–2.28) and NNTH = 14 (8–61). <b>Conclusions:</b> Based on RCTs of 12 month duration in patients with IPF, a positive effect on FVC decline was noted for both treatments and on dropouts for nintedanib, but no significant differences were noted between treatments.
DOI: 10.6084/m9.figshare.7867544
title: ThzLecRLK.xlsx

description: The CDS sequences of the 297 ThzLecRLK genes identified by bioinformatics methods. The unigene sequences of T. hybrid 'Zhongshanshan' were derived from the previously determined salinity stress transcriptome,short-term waterlogging transcriptome and adventitious roots transcriptome. Hidden Markov Model (HMM) profiles (PF00069, PF01453, PF00139, PF00059), which correspond to kinase, G-type lectin, L-type lectin and C-type lectin domains, respectively, were downloaded from Pfam (http://pfam.xfam.org/). We retrieved genes containing a kinase domain by running the hmmsearch program (HMMER 2.3.2) to search the kinase profile (PF00069) against the proteomic sequences. Within this set of hypothetical kinase proteins, we searched for G-type lectin, L-type lectin and C-type lectin HMM profiles (PF01453, PF00139, PF00059) (E value cut-off &lt; 1). Sequences in which we identified a protein kinase domain (PF00069), along with either a G-type lectin (PF01453), an L-type lectin (PF00139), or a C-type lectin domain (PF00059) were considered putative LecRLKs (GmLecRLKs) and finally confirmed as ThzLecRLK genes after removing redundant sequences with 97% similarity between different database.
DOI: 10.6084/m9.figshare.7867565.v1
title: Systematic review and network meta-analysis of approved medicines for the treatment of idiopathic pulmonary fibrosis

description: <b>Background:</b> Clinical practice guidelines for the treatment of idiopathic pulmonary fibrosis (IPF) currently recommend pirfenidone and nintedanib. However, there is a lack of evidence from head-to-head comparisons. <b>Objectives:</b> To perform a systematic review and network meta-analysis (NMA) to access the efficacy and tolerability of two new treatments for IPF, pirfenidone and nintedanib. <b>Methods</b>: Randomized controlled trials (RCTs) selection (CENTRAL, MEDLINE, Embase), data extraction, risk of bias analysis and GRADE assessment were carried out by two authors separately. Direct estimates were calculated using standard pairwise meta-analysis. A Bayesian mixed treatment comparison approach for NMA estimates, with 95% confidence intervals (CI), was used to compare the treatments, calculating odds ratios (OR) and number needed to treat (NNTB) or harm (NNTH). <b>Results:</b> The NMA on 10 randomized controlled trials showed that each drug had a positive effect on percentage of forced vital capacity (FVC) decline ≥10% (pirfenidone OR 0.54 [95% CI 0.37-0.80], NNTB 9 [95% CI 7-22]; nintedanib OR 0.59 [95% CI 0.41-0.84], NNTB 9 [95% CI 6-23]), but no significant differences were noted when comparing pirfenidone and nintedanib with respect to acute exacerbations, mortality and serious adverse events (FVC decline OR 0.91 [95% CI 0.45-2.03]) or dropouts (OR 0.75 [95% CI 0.33-1.27]). Nintedanib showed an effect on dropouts OR 1.61 (1.13-2.28) and NNTH 14 (8-61). Conclusions<b>:</b> Based on RCTs of 12 month duration in patients with IPF a positive effect on FVC decline was noted for both treatments and on dropouts for nintedanib, but no significant differences were noted between treatments.
DOI: 10.6084/m9.figshare.7867517
title: Additional file 9: of Species-specific enhancement of enterohemorrhagic E. coli pathogenesis mediated by microbiome metabolites

description: Table S2. List of 30 known metabolites enriched in Hmm compared to Mmm that were selected for fliC-luciferase screening (CAS n: Chemical Abstracts Service number; “name”: metabolites with a known name; “similarity”: closest MSMS spectrum in the reference database to the analyte, with a 95% confidence in identification). (XLSX 10 kb)
DOI: 10.6084/m9.figshare.7867517.v1
title: Additional file 9: of Species-specific enhancement of enterohemorrhagic E. coli pathogenesis mediated by microbiome metabolites

description: Table S2. List of 30 known metabolites enriched in Hmm compared to Mmm that were selected for fliC-luciferase screening (CAS n: Chemical Abstracts Service number; “name”: metabolites with a known name; “similarity”: closest MSMS spectrum in the reference database to the analyte, with a 95% confidence in identification). (XLSX 10 kb)
DOI: 10.6084/m9.figshare.7867505
title: Additional file 5: of Species-specific enhancement of enterohemorrhagic E. coli pathogenesis mediated by microbiome metabolites

description: Table S1. Transcriptomics analysis of long polar fimbriae genes.. (XLSX 8â kb)
DOI: 10.6084/m9.figshare.7867505.v1
title: Additional file 5: of Species-specific enhancement of enterohemorrhagic E. coli pathogenesis mediated by microbiome metabolites

description: Table S1. Transcriptomics analysis of long polar fimbriae genes.. (XLSX 8â kb)
DOI: 10.6084/m9.figshare.7867487
title: Additional file 15: of Species-specific enhancement of enterohemorrhagic E. coli pathogenesis mediated by microbiome metabolites

description: Table S3. Reagents and resources. (XLSX 16â kb)
DOI: 10.6084/m9.figshare.7867490
title: Additional file 16: of Species-specific enhancement of enterohemorrhagic E. coli pathogenesis mediated by microbiome metabolites

description: Table S4. 16â s rRNA gene data. (CSV 291â kb)
DOI: 10.6084/m9.figshare.7867490.v1
title: Additional file 16: of Species-specific enhancement of enterohemorrhagic E. coli pathogenesis mediated by microbiome metabolites

description: Table S4. 16â s rRNA gene data. (CSV 291â kb)
DOI: 10.6084/m9.figshare.7867487.v1
title: Additional file 15: of Species-specific enhancement of enterohemorrhagic E. coli pathogenesis mediated by microbiome metabolites

description: Table S3. Reagents and resources. (XLSX 16â kb)
DOI: 10.6084/m9.figshare.7867430
title: Additional file 1 of Machine learning in medicine: a practical introduction

description: Breast Cancer Wisconsin Dataset. Anonomised dataset used in this work. (CSV 24.9 kb)
DOI: 10.6084/m9.figshare.7867430.v1
title: Additional file 1 of Machine learning in medicine: a practical introduction

description: Breast Cancer Wisconsin Dataset. Anonomised dataset used in this work. (CSV 24.9 kb)
DOI: 10.6084/m9.figshare.7867403
title: MOESM1 of Molecular characterization and distribution of Schistosoma cercariae collected from naturally infected bulinid snails in northern and central Côte d’Ivoire

description: Additional file 1: Table S1. Snail collection and schistosome infection data. N = North, C = Central. Snail identification is based on shell morphology, except for the positive snails that were molecularly identified.
DOI: 10.6084/m9.figshare.7867403.v1
title: MOESM1 of Molecular characterization and distribution of Schistosoma cercariae collected from naturally infected bulinid snails in northern and central Côte d’Ivoire

description: Additional file 1: Table S1. Snail collection and schistosome infection data. N = North, C = Central. Snail identification is based on shell morphology, except for the positive snails that were molecularly identified.
DOI: 10.6084/m9.figshare.7867373
title: MOESM6 of Short-term metabolic adjustments in Plasmodium falciparum counter hypoxanthine deprivation at the expense of long-term viability

description: Additional file 6. Gene set enrichment analysis of transcriptomic data from isoleucine-deprived Plasmodium falciparum.
DOI: 10.6084/m9.figshare.7867364
title: MOESM5 of Short-term metabolic adjustments in Plasmodium falciparum counter hypoxanthine deprivation at the expense of long-term viability

description: Additional file 5. Gene set enrichment analysis of transcriptomic data from hypoxanthine-deprived Plasmodium falciparum.
DOI: 10.6084/m9.figshare.7867367
title: MOESM1 of Monitoring the impact of intensive shallow geothermal energy use on groundwater temperatures in a residential neighborhood

description: Additional file 1: Data file containing relevant test site information as well as hydrogeological and groundwater temperature data.
DOI: 10.6084/m9.figshare.7867373.v1
title: MOESM6 of Short-term metabolic adjustments in Plasmodium falciparum counter hypoxanthine deprivation at the expense of long-term viability

description: Additional file 6. Gene set enrichment analysis of transcriptomic data from isoleucine-deprived Plasmodium falciparum.
DOI: 10.6084/m9.figshare.7867358
title: MOESM3 of Short-term metabolic adjustments in Plasmodium falciparum counter hypoxanthine deprivation at the expense of long-term viability

description: Additional file 3. List of metabolites detected under hypoxanthine-rich and -deprived conditions.
DOI: 10.6084/m9.figshare.7867361
title: MOESM4 of Short-term metabolic adjustments in Plasmodium falciparum counter hypoxanthine deprivation at the expense of long-term viability

description: Additional file 4. Significantly altered metabolic genes and reactions of Plasmodium falciparum in response to hypoxanthine deprivation.
DOI: 10.6084/m9.figshare.7867355
title: MOESM2 of Short-term metabolic adjustments in Plasmodium falciparum counter hypoxanthine deprivation at the expense of long-term viability

description: Additional file 2. Significantly altered erythrocyte reactions in response to parasite infection and hypoxanthine concentration.
DOI: 10.6084/m9.figshare.7867361.v1
title: MOESM4 of Short-term metabolic adjustments in Plasmodium falciparum counter hypoxanthine deprivation at the expense of long-term viability

description: Additional file 4. Significantly altered metabolic genes and reactions of Plasmodium falciparum in response to hypoxanthine deprivation.
DOI: 10.6084/m9.figshare.7867364.v1
title: MOESM5 of Short-term metabolic adjustments in Plasmodium falciparum counter hypoxanthine deprivation at the expense of long-term viability

description: Additional file 5. Gene set enrichment analysis of transcriptomic data from hypoxanthine-deprived Plasmodium falciparum.
DOI: 10.6084/m9.figshare.7867367.v1
title: MOESM1 of Monitoring the impact of intensive shallow geothermal energy use on groundwater temperatures in a residential neighborhood

description: Additional file 1: Data file containing relevant test site information as well as hydrogeological and groundwater temperature data.
DOI: 10.6084/m9.figshare.7867358.v1
title: MOESM3 of Short-term metabolic adjustments in Plasmodium falciparum counter hypoxanthine deprivation at the expense of long-term viability

description: Additional file 3. List of metabolites detected under hypoxanthine-rich and -deprived conditions.
DOI: 10.6084/m9.figshare.7867355.v1
title: MOESM2 of Short-term metabolic adjustments in Plasmodium falciparum counter hypoxanthine deprivation at the expense of long-term viability

description: Additional file 2. Significantly altered erythrocyte reactions in response to parasite infection and hypoxanthine concentration.
DOI: 10.6084/m9.figshare.7867268
title: Additional file 6: of Risk-modeling of dog osteosarcoma genome scans shows individuals with Mendelian-level polygenic risk are common

description: Data. Haplotype phasing across osteosarcoma GWAS risk alleles. (ZIP 162 kb)
DOI: 10.6084/m9.figshare.7867268.v1
title: Additional file 6: of Risk-modeling of dog osteosarcoma genome scans shows individuals with Mendelian-level polygenic risk are common

description: Data. Haplotype phasing across osteosarcoma GWAS risk alleles. (ZIP 162 kb)
DOI: 10.6084/m9.figshare.7867259
title: Additional file 5: of Risk-modeling of dog osteosarcoma genome scans shows individuals with Mendelian-level polygenic risk are common

description: Table S3. Updated and expanded annotation of canine osteosarcoma GWAS loci. Table S4. Gene list for biochemical pathway and transcription factor (TF) binding site analyses. Table S5. Full results of combined biochemical pathway and TF analyses of Table S4 genes (DAVID, Huang et al., PMID: 19033363; PMID: 19033363). Table S5-trim. Table S5 trimmed to only include categories associated with the 13 canine genes likely to be associated with germ line risk of osteosarcoma. (XLSX 214 kb)
DOI: 10.6084/m9.figshare.7867259.v1
title: Additional file 5: of Risk-modeling of dog osteosarcoma genome scans shows individuals with Mendelian-level polygenic risk are common

description: Table S3. Updated and expanded annotation of canine osteosarcoma GWAS loci. Table S4. Gene list for biochemical pathway and transcription factor (TF) binding site analyses. Table S5. Full results of combined biochemical pathway and TF analyses of Table S4 genes (DAVID, Huang et al., PMID: 19033363; PMID: 19033363). Table S5-trim. Table S5 trimmed to only include categories associated with the 13 canine genes likely to be associated with germ line risk of osteosarcoma. (XLSX 214 kb)
DOI: 10.6084/m9.figshare.7867241
title: Additional file 3: of Risk-modeling of dog osteosarcoma genome scans shows individuals with Mendelian-level polygenic risk are common

description: Table S2. Risk modeling odds ratios calculated by Firthâ s logistic regression. (XLSX 28 kb)
DOI: 10.6084/m9.figshare.7867241.v1
title: Additional file 3: of Risk-modeling of dog osteosarcoma genome scans shows individuals with Mendelian-level polygenic risk are common

description: Table S2. Risk modeling odds ratios calculated by Firthâ s logistic regression. (XLSX 28 kb)
DOI: 10.6084/m9.figshare.7867229
title: Additional file 2: of Risk-modeling of dog osteosarcoma genome scans shows individuals with Mendelian-level polygenic risk are common

description: Table S1. Intersection Union Testing GWAS p-values (individual set, MaxP and Fisherâ s Combined). (XLSX 42086 kb)
DOI: 10.6084/m9.figshare.7867229.v1
title: Additional file 2: of Risk-modeling of dog osteosarcoma genome scans shows individuals with Mendelian-level polygenic risk are common

description: Table S1. Intersection Union Testing GWAS p-values (individual set, MaxP and Fisherâ s Combined). (XLSX 42086 kb)
DOI: 10.6084/m9.figshare.7867214
title: Additional file 3: of Transcriptional response of cultured porcine intestinal epithelial cells to micro algae extracts in the presence and absence of enterotoxigenic Escherichia coli

description: DEGs involved in specific biological processes. A). Regulatory genes. B). Immune effector proteins (EPs). C). NRF2-pathway. D). Beta-oxidation. (XLSX 54 kb)
DOI: 10.6084/m9.figshare.7867211
title: Additional file 2: of Transcriptional response of cultured porcine intestinal epithelial cells to micro algae extracts in the presence and absence of enterotoxigenic Escherichia coli

description: DEGs microarray comparisons and functional (pathway) analysis. A). Lists of DEGs used for pathway analysis. B). Enriched pathways without ETEC. C). Enriched pathways with ETEC. (XLSX 392 kb)
DOI: 10.6084/m9.figshare.7867211.v1
title: Additional file 2: of Transcriptional response of cultured porcine intestinal epithelial cells to micro algae extracts in the presence and absence of enterotoxigenic Escherichia coli

description: DEGs microarray comparisons and functional (pathway) analysis. A). Lists of DEGs used for pathway analysis. B). Enriched pathways without ETEC. C). Enriched pathways with ETEC. (XLSX 392 kb)
DOI: 10.6084/m9.figshare.12881432
title: Supplementary Data - genomewide r2 for each population

description: Four allele combinations & if a recombination event is suspected to have occured.
DOI: 10.6084/m9.figshare.12881432.v1
title: Supplementary Data - genomewide r2 for each population

description: Four allele combinations & if a recombination event is suspected to have occured.
DOI: 10.6084/m9.figshare.7867214.v1
title: Additional file 3: of Transcriptional response of cultured porcine intestinal epithelial cells to micro algae extracts in the presence and absence of enterotoxigenic Escherichia coli

description: DEGs involved in specific biological processes. A). Regulatory genes. B). Immune effector proteins (EPs). C). NRF2-pathway. D). Beta-oxidation. (XLSX 54 kb)
DOI: 10.6084/m9.figshare.7867175
title: Additional file 3: of Genome-wide identification and characterization of abiotic-stress responsive SOD (superoxide dismutase) gene family in Brassica juncea and B. rapa

description: a Figure depicts the multiple sequence alignment of Cu-ZnSODs from B. rapa, anti-parallel β-strands are shown by over head red arrows, Cu binding residues are shown in yellow asterisk, Zn residues in blue asterisk, Bridging histidine is represented by two asterisk. Also various important structural elements are shown like V-loop (Variable loop with over head yellow line), Electrostatic loop (Green) and Greek key loops 1 and 2 (GK1 and GK2 in purple). The Cu2+ and Zn2+ motif signature sequence is highlighted in black box. b Figure shows the multiple sequence alignment of MnSODs from B. rapa, wherein their metal binding sites is highlighted in black box and the metal binding residues are marked with blue asterisks. Also the α-helices and β-sheets are shown by over head black arrows. c Figure shows the multiple sequence alignment of FeSODs from B. rapa, wherein their metal binding sites is highlighted in black box and the metal binding residues are marked with pink asterisks. Also the α-helices and β-sheets are shown by over head black arrows. (ZIP 2377 kb)
DOI: 10.6084/m9.figshare.7867175.v1
title: Additional file 3: of Genome-wide identification and characterization of abiotic-stress responsive SOD (superoxide dismutase) gene family in Brassica juncea and B. rapa

description: a Figure depicts the multiple sequence alignment of Cu-ZnSODs from B. rapa, anti-parallel β-strands are shown by over head red arrows, Cu binding residues are shown in yellow asterisk, Zn residues in blue asterisk, Bridging histidine is represented by two asterisk. Also various important structural elements are shown like V-loop (Variable loop with over head yellow line), Electrostatic loop (Green) and Greek key loops 1 and 2 (GK1 and GK2 in purple). The Cu2+ and Zn2+ motif signature sequence is highlighted in black box. b Figure shows the multiple sequence alignment of MnSODs from B. rapa, wherein their metal binding sites is highlighted in black box and the metal binding residues are marked with blue asterisks. Also the α-helices and β-sheets are shown by over head black arrows. c Figure shows the multiple sequence alignment of FeSODs from B. rapa, wherein their metal binding sites is highlighted in black box and the metal binding residues are marked with pink asterisks. Also the α-helices and β-sheets are shown by over head black arrows. (ZIP 2377 kb)