cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.5841519
title: Supplementary Material for: Use of Mobile Devices to Measure Outcomes in Clinical Research, 2010–2016: A Systematic Literature Review

description: <b><i>Background:</i></b> The use of mobile devices in clinical research has advanced substantially in recent years due to the rapid pace of technology development. With an overall aim of informing the future use of mobile devices in interventional clinical research to measure primary outcomes, we conducted a systematic review of the use of and clinical outcomes measured by mobile devices (mobile outcomes) in observational and interventional clinical research. <b><i>Method:</i></b> We conducted a PubMed search using a range of search terms to retrieve peer-reviewed articles on clinical research published between January 2010 and May 2016 in which mobile devices were used to measure study outcomes. We screened each publication for specific inclusion and exclusion criteria. We then identified and qualitatively summarized the use of mobile outcome assessments in clinical research, including the type and design of the study, therapeutic focus, type of mobile device(s) used, and specific mobile outcomes reported. <b><i>Results:</i></b> The search retrieved 2,530 potential articles of interest. After screening, 88 publications remained. Twenty-five percent of the publications (<i>n</i> = 22) described mobile outcomes used in interventional research, and the rest (<i>n</i> = 66) described observational clinical research. Thirteen therapeutic areas were represented. Five categories of mobile devices were identified: (1) inertial sensors, (2) biosensors, (3) pressure sensors and walkways, (4) medication adherence monitors, and (5) location monitors; inertial sensors/accelerometers were most common (reported in 86% of the publications). Among the variety of mobile outcomes, various assessments of physical activity were most common (reported in 74% of the publications). Other mobile outcomes included assessments of sleep, mobility, and pill adherence, as well as biomarkers assessed using a mobile device, including cardiac measures, glucose, gastric reflux, respiratory measures, and intensity of head-related injury. <b><i>Conclusion:</i></b> Mobile devices are being widely used in clinical research to assess outcomes, although their use in interventional research to assess therapeutic effectiveness is limited. For mobile devices to be used more frequently in pivotal interventional research – such as trials informing regulatory decision-making – more focus should be placed on: (1) consolidating the evidence supporting the clinical meaningfulness of specific mobile outcomes, and (2) standardizing the use of mobile devices in clinical research to measure specific mobile outcomes (e.g., data capture frequencies, placement of device). To that aim, this manuscript offers a broad overview of the various mobile outcome assessments currently used in observational and interventional research, and categorizes and consolidates this information for researchers interested in using mobile devices to assess outcomes in interventional research.
DOI: 10.6084/m9.figshare.5841510
title: Dataset for: Sensitivity of the Circadian System to Evening Bright Light in Preschool-Age Children

description: Although the light-induced melatonin suppression response is well characterized in adults, studies examining the dynamics of this effect in children are scarce. The purpose of this study was to quantify the magnitude of evening light-induced melatonin suppression in preschool age children. Healthy preschool-age children (n=10; 7 females; 4.3±1.1 years) participated in a 7-day protocol. On days 1-5, children followed a strict sleep schedule. On day 6, children entered a dim light environment (&lt;15 lux) for 1-hour before providing salivary samples every 20- to 30-minutes from the afternoon until 50-minutes after scheduled bedtime. On day 7, subjects remained in dim light conditions until 1-hour before bedtime, at which time they were exposed to a bright light stimulus (~1,000 lux) for 1-hour and then re-entered dim light conditions. Saliva samples were obtained before, during, and after bright light exposure and were time-anchored to samples taken the previous evening. We found robust melatonin suppression (87.6±10.0%) in response to the bright light stimulus. Melatonin levels remained attenuated for 50-minutes after termination of the light stimulus (p&lt;0.008). Furthermore, melatonin levels did not return to 50% of those observed in the dim light condition 50-minutes after the light exposure for 7/10 children. Our findings demonstrate a robust light-induced melatonin suppression response in preschool-age children. These findings have implications for understanding the role of evening light exposure in the development of evening settling difficulties and may serve as experimental evidence to support recommendations regarding light exposure and sleep hygiene practices in early childhood.
DOI: 10.6084/m9.figshare.5841465
title: Supplementary Material for: Cohort Profile: The Swiss Eosinophilic Esophagitis Cohort Study (SEECS)

description: <b><i>Background and Aims:</i></b> The prospective, observational Swiss Eosinophilic Esophagitis Cohort Study (SEECS) was set up in 2015 with the following goals in mind: (1) to provide up-to-date epidemiologic data; (2) to assess the appropriateness of care; (3) to evaluate the psychosocial impact; and (4) to foster translational research projects. Data capture relies on validated instruments to assess disease activity and focuses on epidemiologic variables and biosamples (esophageal biopsies and blood specimens). An annual inclusion of 70 new patients with eosinophilic esophagitis (EoE) or proton pump inhibitor-responsive esophageal eosinophilia (PPI-REE) is intended. We herein describe the SEECS cohort profile. <b><i>Methods:</i></b> The SEECS includes adult patients (age ≥18 years) with EoE or PPI-REE diagnosed according to published criteria. After inclusion, the patients are typically seen once a year for a clinical and endoscopic/histologic follow-up examination. Data are captured using validated questionnaires. Biosamples from patients with gastroesophageal reflux disease (GERD) and controls with a healthy esophagus are collected as well. <b><i>Results:</i></b> From January 2016 to July 2017, a total of 111 patients with EoE and 10 patients with PPI-REE were recruited. In addition, esophageal biopsies and blood samples from 11 patients with GERD and 20 controls with a healthy esophagus were collected. The mean age of the patients with EoE and those with PPI-REE was 39.6 ± 12.9 and 44.6 ± 15.6 years, respectively. A male predominance was found among both the patients with EoE (77.5%) and those with PPI-REE (70%). Concomitant allergic disorders were found in 79.3% of the patients with EoE and 90% of the patients with PPI-REE. At inclusion, the EoE patients were treated with the following therapeutic regimens: no therapy (0.9%), PPI (36%), swallowed topical corticosteroids (82.9%), elimination diets (15.3%), and esophageal dilation (19.8%). <b><i>Conclusions:</i></b> The SEECS is the first national cohort study of patients with EoE or PPI-REE. The SEECS will provide up-to-date epidemiologic data and foster translational research projects.
DOI: 10.6084/m9.figshare.5841510.v1
title: Dataset for: Sensitivity of the Circadian System to Evening Bright Light in Preschool-Age Children

description: Although the light-induced melatonin suppression response is well characterized in adults, studies examining the dynamics of this effect in children are scarce. The purpose of this study was to quantify the magnitude of evening light-induced melatonin suppression in preschool age children. Healthy preschool-age children (n=10; 7 females; 4.3±1.1 years) participated in a 7-day protocol. On days 1-5, children followed a strict sleep schedule. On day 6, children entered a dim light environment (&lt;15 lux) for 1-hour before providing salivary samples every 20- to 30-minutes from the afternoon until 50-minutes after scheduled bedtime. On day 7, subjects remained in dim light conditions until 1-hour before bedtime, at which time they were exposed to a bright light stimulus (~1,000 lux) for 1-hour and then re-entered dim light conditions. Saliva samples were obtained before, during, and after bright light exposure and were time-anchored to samples taken the previous evening. We found robust melatonin suppression (87.6±10.0%) in response to the bright light stimulus. Melatonin levels remained attenuated for 50-minutes after termination of the light stimulus (p&lt;0.008). Furthermore, melatonin levels did not return to 50% of those observed in the dim light condition 50-minutes after the light exposure for 7/10 children. Our findings demonstrate a robust light-induced melatonin suppression response in preschool-age children. These findings have implications for understanding the role of evening light exposure in the development of evening settling difficulties and may serve as experimental evidence to support recommendations regarding light exposure and sleep hygiene practices in early childhood.
DOI: 10.6084/m9.figshare.5841465.v1
title: Supplementary Material for: Cohort Profile: The Swiss Eosinophilic Esophagitis Cohort Study (SEECS)

description: <b><i>Background and Aims:</i></b> The prospective, observational Swiss Eosinophilic Esophagitis Cohort Study (SEECS) was set up in 2015 with the following goals in mind: (1) to provide up-to-date epidemiologic data; (2) to assess the appropriateness of care; (3) to evaluate the psychosocial impact; and (4) to foster translational research projects. Data capture relies on validated instruments to assess disease activity and focuses on epidemiologic variables and biosamples (esophageal biopsies and blood specimens). An annual inclusion of 70 new patients with eosinophilic esophagitis (EoE) or proton pump inhibitor-responsive esophageal eosinophilia (PPI-REE) is intended. We herein describe the SEECS cohort profile. <b><i>Methods:</i></b> The SEECS includes adult patients (age ≥18 years) with EoE or PPI-REE diagnosed according to published criteria. After inclusion, the patients are typically seen once a year for a clinical and endoscopic/histologic follow-up examination. Data are captured using validated questionnaires. Biosamples from patients with gastroesophageal reflux disease (GERD) and controls with a healthy esophagus are collected as well. <b><i>Results:</i></b> From January 2016 to July 2017, a total of 111 patients with EoE and 10 patients with PPI-REE were recruited. In addition, esophageal biopsies and blood samples from 11 patients with GERD and 20 controls with a healthy esophagus were collected. The mean age of the patients with EoE and those with PPI-REE was 39.6 ± 12.9 and 44.6 ± 15.6 years, respectively. A male predominance was found among both the patients with EoE (77.5%) and those with PPI-REE (70%). Concomitant allergic disorders were found in 79.3% of the patients with EoE and 90% of the patients with PPI-REE. At inclusion, the EoE patients were treated with the following therapeutic regimens: no therapy (0.9%), PPI (36%), swallowed topical corticosteroids (82.9%), elimination diets (15.3%), and esophageal dilation (19.8%). <b><i>Conclusions:</i></b> The SEECS is the first national cohort study of patients with EoE or PPI-REE. The SEECS will provide up-to-date epidemiologic data and foster translational research projects.
DOI: 10.17028/rd.lboro.5841321
title: Supplementary information files for "Direct analysis of volatile organic compounds in foods by headspace extraction atmospheric pressure chemical ionisation mass spectrometry"

description: Supplementary information files for "Direct analysis of volatile organic compounds in foods by headspace extraction atmospheric pressure chemical ionisation mass spectrometry"<br><b>Figure S1</b>. APCI-MS analysis of a 16.5 μg/ml indole standard in 50:50 MeOH/H<sub>2</sub>O + 0.1% Formic acid<b>FIGURE S2.</b> Calibration curve of indole standard that demonstrates the quantitative capabilities of the system<b>Table S1.</b> Variables list used in the cheese PCA-X model.<b>Figure S1</b>. APCI-MS analysis of a 16.5 μg/ml indole standard in 50:50 MeOH/H<sub>2</sub>O + 0.1% Formic acid<b>Figure S2</b>. S:N ratio measurements from 3 replicate APCI-MS analyses of a 1 μg/ml indole standard in 50:50 MeOH/H<sub>2</sub>O + 0.1% Formic acid<br>AbstractRationaleThe rapid screening of volatile organic compounds (VOCs) by direct analysis has potential applications in the areas of food and flavour science. Currently, the technique of choice for VOC analysis is gas chromatography/mass spectrometry (GC/MS). However, the long chromatographic run times and elaborate sample preparation associated with this technique have led a movement towards direct analysis techniques, such as selected ion flow tube mass spectrometry (SIFT-MS), proton transfer reaction mass spectrometry (PTR-MS) and electronic noses. The work presented here describes the design and construction of a Venturi jet-pump-based modification for a compact mass spectrometer which enables the direct introduction of volatiles for qualitative and quantitative analysis.MethodsVolatile organic compounds were extracted from the headspace of heated vials into the atmospheric pressure chemical ionization source of a quadrupole mass spectrometer using a Venturi pump. Samples were analysed directly with no prior sample preparation. Principal component analysis (PCA) was used to differentiate between different classes of samples.ResultsThe interface is shown to be able to routinely detect problem analytes such as fatty acids and biogenic amines without the requirement of a derivatisation step, and is shown to be able to discriminate between four different varieties of cheese with good intra and inter-day reproducibility using an unsupervised PCA model. Quantitative analysis is demonstrated using indole standards with limits of detection and quantification of 0.395 μg/mL and 1.316 μg/mL, respectively.ConclusionsThe described methodology can routinely detect highly reactive analytes such as volatile fatty acids and diamines without the need for a derivatisation step or lengthy chromatographic separations. The capability of the system was demonstrated by discriminating between different varieties of cheese and monitoring the spoilage of meats.
DOI: 10.17028/rd.lboro.5841321.v1
title: Supplementary information files for "Direct analysis of volatile organic compounds in foods by headspace extraction atmospheric pressure chemical ionisation mass spectrometry"

description: Supplementary information files for "Direct analysis of volatile organic compounds in foods by headspace extraction atmospheric pressure chemical ionisation mass spectrometry"<br><b>Figure S1</b>. APCI-MS analysis of a 16.5 μg/ml indole standard in 50:50 MeOH/H<sub>2</sub>O + 0.1% Formic acid<b>FIGURE S2.</b> Calibration curve of indole standard that demonstrates the quantitative capabilities of the system<b>Table S1.</b> Variables list used in the cheese PCA-X model.<b>Figure S1</b>. APCI-MS analysis of a 16.5 μg/ml indole standard in 50:50 MeOH/H<sub>2</sub>O + 0.1% Formic acid<b>Figure S2</b>. S:N ratio measurements from 3 replicate APCI-MS analyses of a 1 μg/ml indole standard in 50:50 MeOH/H<sub>2</sub>O + 0.1% Formic acid<br>AbstractRationaleThe rapid screening of volatile organic compounds (VOCs) by direct analysis has potential applications in the areas of food and flavour science. Currently, the technique of choice for VOC analysis is gas chromatography/mass spectrometry (GC/MS). However, the long chromatographic run times and elaborate sample preparation associated with this technique have led a movement towards direct analysis techniques, such as selected ion flow tube mass spectrometry (SIFT-MS), proton transfer reaction mass spectrometry (PTR-MS) and electronic noses. The work presented here describes the design and construction of a Venturi jet-pump-based modification for a compact mass spectrometer which enables the direct introduction of volatiles for qualitative and quantitative analysis.MethodsVolatile organic compounds were extracted from the headspace of heated vials into the atmospheric pressure chemical ionization source of a quadrupole mass spectrometer using a Venturi pump. Samples were analysed directly with no prior sample preparation. Principal component analysis (PCA) was used to differentiate between different classes of samples.ResultsThe interface is shown to be able to routinely detect problem analytes such as fatty acids and biogenic amines without the requirement of a derivatisation step, and is shown to be able to discriminate between four different varieties of cheese with good intra and inter-day reproducibility using an unsupervised PCA model. Quantitative analysis is demonstrated using indole standards with limits of detection and quantification of 0.395 μg/mL and 1.316 μg/mL, respectively.ConclusionsThe described methodology can routinely detect highly reactive analytes such as volatile fatty acids and diamines without the need for a derivatisation step or lengthy chromatographic separations. The capability of the system was demonstrated by discriminating between different varieties of cheese and monitoring the spoilage of meats.
DOI: 10.17028/rd.lboro.5841273
title: Supplementary information files for "Comparing threshold definition techniques for rainfall-induced landslides: A national assessment using radar rainfall"

description: Supplementary information files for "Comparing threshold definition techniques for rainfall-induced landslides: A national assessment using radar rainfall"<br>AbstractTranslational landslides and debris flows are often initiated during intense or prolonged rainfall. Empirical thresholds aim to classify the rain conditions that are commonly associated with landslide occurrence and therefore improve understating of these hazards and predictive ability. Objective techniques that are used to determine these thresholds are likely to be affected by the length of the rain record used, yet this is not routinely considered. Moreover, remotely sensed spatially continuous rainfall observations are under-exploited. This study compares and evaluates the effect of rain record length on two objective threshold selection techniques in a national assessment of Scotland using weather radar data. Thresholds selected by ‘threat score’ are sensitive to rain record length whereas, in a first application to landslides, ‘optimal point’ (OP) thresholds prove relatively consistent. OP thresholds increase landslide detection and may therefore be applicable in early-warning systems. Thresholds combining 1- and 12-day antecedence variables best distinguish landslide initiation conditions and indicate that Scottish landslides may be initiated by lower rain accumulation and intensities than previously thought.
DOI: 10.17028/rd.lboro.5841273.v1
title: Supplementary information files for "Comparing threshold definition techniques for rainfall-induced landslides: A national assessment using radar rainfall"

description: Supplementary information files for "Comparing threshold definition techniques for rainfall-induced landslides: A national assessment using radar rainfall"<br>AbstractTranslational landslides and debris flows are often initiated during intense or prolonged rainfall. Empirical thresholds aim to classify the rain conditions that are commonly associated with landslide occurrence and therefore improve understating of these hazards and predictive ability. Objective techniques that are used to determine these thresholds are likely to be affected by the length of the rain record used, yet this is not routinely considered. Moreover, remotely sensed spatially continuous rainfall observations are under-exploited. This study compares and evaluates the effect of rain record length on two objective threshold selection techniques in a national assessment of Scotland using weather radar data. Thresholds selected by ‘threat score’ are sensitive to rain record length whereas, in a first application to landslides, ‘optimal point’ (OP) thresholds prove relatively consistent. OP thresholds increase landslide detection and may therefore be applicable in early-warning systems. Thresholds combining 1- and 12-day antecedence variables best distinguish landslide initiation conditions and indicate that Scottish landslides may be initiated by lower rain accumulation and intensities than previously thought.
DOI: 10.6084/m9.figshare.5841267
title: Nevsky prospect traffic surveillance video(movement by the opposite lane cases hours)

description: This is an extraction from the larger dataset. It consist of hours when MBOL(movement by the opposite lane) cases were observed.<br><br>Video compilation of the cases is in file "oncoming.avi".<br><br>Video compilation for other the dataset(Author: Ivan Derevitskii, License: CC-BY-4.0, Title: "St Petersburg traffic videos") is in the file "oncoming_other_dataset.mp4".https://figshare.com/articles/St_Petersburg_traffic_videos/5439706<br>The data set contains traffic surveillance video in the area of Nevsky prospect(central street of Saint Petersburg) between the Moika river and the street Bolshaya Konuyshennaya. The covered area contains two-way road with dense vehicle movement. The length of the selected area is 102 meters, width is 17.5 meters. The resolution of each video is 960x720 pixels. The data set was colected in November, December in 2017 and January 2018.<br>
DOI: 10.6084/m9.figshare.5841267.v1
title: Nevsky prospect traffic surveillance video(MOOL-cases hours)

description: This is an extraction from the larger dataset. It consist of hours when MOOL(movement on the oncoming lane) cases were observed.<br>The data set contains traffic surveillance video in the area of Nevsky prospect(central street of Saint Petersburg) between the Moika river and the street Bolshaya Konuyshennaya. The covered area contains two-way road with dense vehicle movement. The length of the selected area is 102 meters, width is 17.5 meters. The resolution of each video is 960x720 pixels. The data set was colected in November, December in 2017 and January 2018.<br>
DOI: 10.6084/m9.figshare.5841267.v2
title: Nevsky prospect traffic surveillance video(MOOL-cases hours)

description: This is an extraction from the larger dataset. It consist of hours when MOOL(movement on the oncoming lane) cases were observed.<br>The data set contains traffic surveillance video in the area of Nevsky prospect(central street of Saint Petersburg) between the Moika river and the street Bolshaya Konuyshennaya. The covered area contains two-way road with dense vehicle movement. The length of the selected area is 102 meters, width is 17.5 meters. The resolution of each video is 960x720 pixels. The data set was colected in November, December in 2017 and January 2018.<br>