cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.10073939.v1
title: Incidence of cystoid macular edema following routine cataract surgery using NSAIDs alone or with corticosteroids

description: ABSTRACT Purpose: To evaluate the rate of cystoid macular edema development among cataract surgery patients on four different therapeutic regimens. Methods: The present study is a retrospective analysis of 5,380 eyes following uncomplicated phacoemulsification at Wake Forest University. The study period went from July 2007 to December 2012. Patients received one of four regimens, as follows: postoperative generic ketorolac 0.4% and prednisolone 1%, postoperative name-brand ketorolac 0.45% and prednisolone 1%, postoperative bromfenac 0.09% and prednisolone 1%, preoperative and postoperative bromfenac 0.09% alone. A statistical analysis was performed to assess the differences in rate of cystoid macular edema development among the four different therapeutic regimens. The diagnosis of cystoid macular edema required worsening of vision and evidence of increased macular thickness on optical coherence tomography. Results: The overall rate of cystoid macular edema was 0.82%. Treatment by postoperative generic ketorolac 0.45% and prednisolone 1% demonstrated the highest rate of cystoid macular edema development (2.20% of the cases). Postoperative name-brand ketorolac 0.45% and prednisolone 1% exhibited intermediate rates of cystoid macular edema development (0.90% of the cases). Postoperative administration of bromfenac 0.09% and prednisolone 1% exhibited intermediate rates of cystoid macular edema development (0.44% of the cases). Preoperative and postoperative bromfenac 0.09% alone resulted in the lowest rate of cystoid macular edema development (0.09% of the cases). The rate of cystoid macular edema was significantly lower when bromfenac was used alone vs. either regimen where ketorolac and prednisolone were used (OR 0.043, 95% CI 0.002 to 0.312; p&lt;0.001). Conclusions: Post-cataract surgery cystoid macular edema developed less frequently following topical non-steroidal anti-inflammatory drugs regimen compared to the other therapies evaluated. Bromfenac, without corticosteroids, achieved lower rates of cystoid macular edema vs. various combinations of non-steroidal anti-inflammatory drugs with corticosteroids.
DOI: 10.6084/m9.figshare.13212751
title: Additional file 10 of A nuclear transport-related gene signature combined with IDH mutation and 1p/19q codeletion better predicts the prognosis of glioma patients

description: Additional file 10: Supplemental Table 6. The list of 251 genes filtered by Univariate Cox regression analysis.
DOI: 10.6084/m9.figshare.14788504
title: Additional file 1 of Antegrade intramedullary fixation for adolescent fifth metacarpal neck fracture and its impact on epiphyseal growth

description: Additional file 1.
DOI: 10.6084/m9.figshare.14788573
title: Additional file 4 of Transcriptomic responses to drought stress among natural populations provide insights into local adaptation of weeping forsythia

description: Additional file 4. The primers of qRT-PCR and gene function for 14 selected genes.
DOI: 10.6084/m9.figshare.12171198
title: Tissue fusion technology versus suture and staple in porcine bowel anastomosis: an in vivo study

description: The aim of this study was to make a comparison between the tissue fusion technique and conventional methods for sealing bowel anastomosis. Eighteen female domestic pigs (Suidae, Sus) were used in our study. Tissue-fused anastomoses (LigaSure groups) were made in 13 animals (5 anastomoses per animal), which were subdivided into 4 groups according to different manufacturing settings: “LigaSure-L-1” and “LigaSure-L-2”, with low energy output level with 1 or 2 device-activated tissue sealing times, and “LigaSure-M” and “LigaSure-H”, with medium or high energy output level. As controls, automatically stapled (GIA group) and hand-sewn (suture group) anastomoses were utilized in 3 and 2 animals, respectively. There was no statistical difference in the overall leakage rate between the GIA group (6.7%) and the LigaSure groups (15%) (P=1.000). There was less proliferating epithelium covering the anastomosis gap in the LigaSure groups compared with the other two groups. The gap between the two extremities of muscular layers of the anastomosis in the LigaSure groups was filled with collagen fibers. More proliferating cell nuclear antigen (PCNA)-positive cells were found in the anastomoses of the LigaSure groups compared with the other two groups (P=0.010). Our results showed that the tissue fusion technology was a feasible and safe method for anastomoses.
DOI: 10.6084/m9.figshare.14788564
title: Additional file 1 of Transcriptomic responses to drought stress among natural populations provide insights into local adaptation of weeping forsythia

description: Additional file 1. Summary of sequence data from 24 samples.
DOI: 10.6084/m9.figshare.14788573.v1
title: Additional file 4 of Transcriptomic responses to drought stress among natural populations provide insights into local adaptation of weeping forsythia

description: Additional file 4. The primers of qRT-PCR and gene function for 14 selected genes.
DOI: 10.6084/m9.figshare.14788576
title: Additional file 5 of Transcriptomic responses to drought stress among natural populations provide insights into local adaptation of weeping forsythia

description: Additional file 5. The data of average annual precipitation for four populations.
DOI: 10.6084/m9.figshare.10074059
title: Effect of Solid Solution Temperature on Microstructure and Corrosion Resistance of CoNiCrMo Alloy

description: Influence of solid solution temperature on microstructures and corrosion properties of CoNiCrMo alloy were investigated by means of optical microscopy (OM), scanning electron microscope (SEM) and electronic differential system. The corrosion resistance of CoNiCrMo alloy in 0.9%NaCl aqueous solution was also investigated. The results indicated that with the increase of solution treatment temperature, the dendrites of CoNiCrMo alloy gradually disappeared. Thus, the corrosion resistance of the alloy decreased. When the solution temperature is 1200ºC, the dendrites almost disappeared and most carbide dissolved, and begins to spheroidization. The corrosion resistance of CoNiCrMo alloy treated at 1000ºC for 1h is the highest than the one at 1100 ºC and 1200ºC. Its self-corrosion potential is -424mV and self-corrosion current density is 1.02×10-8A/cm2.
DOI: 10.6084/m9.figshare.10074059.v1
title: Effect of Solid Solution Temperature on Microstructure and Corrosion Resistance of CoNiCrMo Alloy

description: Influence of solid solution temperature on microstructures and corrosion properties of CoNiCrMo alloy were investigated by means of optical microscopy (OM), scanning electron microscope (SEM) and electronic differential system. The corrosion resistance of CoNiCrMo alloy in 0.9%NaCl aqueous solution was also investigated. The results indicated that with the increase of solution treatment temperature, the dendrites of CoNiCrMo alloy gradually disappeared. Thus, the corrosion resistance of the alloy decreased. When the solution temperature is 1200ºC, the dendrites almost disappeared and most carbide dissolved, and begins to spheroidization. The corrosion resistance of CoNiCrMo alloy treated at 1000ºC for 1h is the highest than the one at 1100 ºC and 1200ºC. Its self-corrosion potential is -424mV and self-corrosion current density is 1.02×10-8A/cm2.
DOI: 10.6084/m9.figshare.14788570
title: Additional file 3 of Transcriptomic responses to drought stress among natural populations provide insights into local adaptation of weeping forsythia

description: Additional file 3. The GO and KEGG enrichment in four populations.
DOI: 10.6084/m9.figshare.10069985
title: Data for: Timing the origin of eukaryotic cellular complexity with ancient duplications

description: Fasta files, phylogenetic trees and their annotations.<br>
DOI: 10.6084/m9.figshare.14788579.v1
title: Additional file 6 of Transcriptomic responses to drought stress among natural populations provide insights into local adaptation of weeping forsythia

description: Additional file 6. The expression and annotation information of the genes in discussion.
DOI: 10.6084/m9.figshare.14788567
title: Additional file 2 of Transcriptomic responses to drought stress among natural populations provide insights into local adaptation of weeping forsythia

description: Additional file 2. The annotated information of all genes.
DOI: 10.6084/m9.figshare.14788570.v1
title: Additional file 3 of Transcriptomic responses to drought stress among natural populations provide insights into local adaptation of weeping forsythia

description: Additional file 3. The GO and KEGG enrichment in four populations.
DOI: 10.6084/m9.figshare.14788579
title: Additional file 6 of Transcriptomic responses to drought stress among natural populations provide insights into local adaptation of weeping forsythia

description: Additional file 6. The expression and annotation information of the genes in discussion.
DOI: 10.6084/m9.figshare.14788576.v1
title: Additional file 5 of Transcriptomic responses to drought stress among natural populations provide insights into local adaptation of weeping forsythia

description: Additional file 5. The data of average annual precipitation for four populations.
DOI: 10.6084/m9.figshare.14788567.v1
title: Additional file 2 of Transcriptomic responses to drought stress among natural populations provide insights into local adaptation of weeping forsythia

description: Additional file 2. The annotated information of all genes.
DOI: 10.6084/m9.figshare.24886530.v1
title: Oxidative Two-State Photoreactivity of a Manganese(IV) Complex using NIR Light

description: description of the data is shown in the Supplementary Information and the main publication
DOI: 10.6084/m9.figshare.24886530
title: Oxidative Two-State Photoreactivity of a Manganese(IV) Complex using NIR Light

description: description of the data is shown in the Supplementary Information and the main publication
DOI: 10.6084/m9.figshare.21080511
title: Prognosis of systemic inflammation at an early stage of cirrhosis using the monocyte-to-lymphocyte ratio during malnutrition risk screening: a prospective cohort study

description: To determine whether the monocyte-to-lymphocyte ratio (MLR), as a systemic inflammation index, predicts malnutrition risk during the early stages of cirrhosis. We conducted a single-center prospective cohort study, enrolling patients from June 2016 to September 2020. The patients underwent malnutrition risk assessments upon admission. The patients were classified into five clinical stages according to portal hypertension. The malnutrition risk was scored using the Royal Free Hospital-Nutritional Prioritizing Tool (RFH-NPT) and validated by the Nutritional Risk Screening 2002 (NRS-2002) or Liver Disease Undernutrition Screening Tool (LDUST). Routine clinical laboratory measurements were performed to calculate the MLR, Child–Turcotte–Pugh (CTP) class, and model for end-stage liver disease (MELD) score. The patients were followed up for 2 years. Among the 154 patients with cirrhosis, 60 had compensated cirrhosis and 94 had decompensated cirrhosis. The optimal cutoff value of the MLR, &gt;0.4, was effective in predicting malnutrition related to death or liver transplantation. Those with a high malnutrition risk defined by the NRS-2002 or RFH-NPT had a higher MLR than those with a low malnutrition risk. For patients with class A CTP cirrhosis or a MELD score of &lt;10, an MLR cutoff of &lt;0.4 significantly distinguished more patients with a low malnutrition risk than those with a high malnutrition risk. Both the RFH-NPT score and MLR increased significantly across the decompensated cirrhosis substages. Interestingly, the MLR exhibited a positive correlation with the RFH-NPT score until varices appeared, but the correlation was the highest at the substage of a history of variceal bleeding (r = 0.714, P = 0.009). Multivariable analysis demonstrated that an MLR of &gt;0.4 was an independent factor for malnutrition risk by screening with the RFH-NPT, and this was confirmed using the LDUST and NRS-2002. Immune-related inflammatory dysfunction predicts malnutrition risk during the early stages of cirrhosis.
DOI: 10.6084/m9.figshare.20031618.v1
title: Sex disparities and the risk of urolithiasis: a large cross-sectional study

description: Urolithiasis is one of the most common diseases in urology, with a lifetime prevalence of 14% and is more prevalent in males compared to females. We designed to explore sex disparities in the Chinese population to provide evidence for prevention measures and mechanisms of stone formation. A total of 98232 Chinese individuals who had undergone a comprehensive examination in 2017 were included. Fully adjusted odds ratios for kidney stones were measured using restricted cubic splines. Multiple imputations was applied for missing values. Propensity score matching was utilised for sensitivity analysis. Among the 98232 included participants, 42762 participants (43.53%) were females and 55470 participants (56.47%) were males. Patients’ factors might cast an influence on the development of kidney stone disease distinctly between the two genders. A risk factor for one gender might have no effect on the other gender. The risk for urolithiasis in females continuously rises as ageing, while for males the risk presents a trend to ascend until the age of around 53 and then descend. Patients’ factors might influence the development of kidney stones distinctly between the two genders. As age grew, the risk to develop kidney stones in females continuously ascended, while the risk in males presented a trend to ascend and then descend, which was presumably related to the weakening of the androgen signals.Key messagesWe found that patients’ factors might cast an influence on the development of kidney stone disease distinctly between the two sexes.The association between age and urolithiasis presents distinct trends in the two sexesThe results will provide evidence to explore the mechanisms underlying such differences can cast light on potential therapeutic targets and promote the development of tailored therapy strategies in prospect. We found that patients’ factors might cast an influence on the development of kidney stone disease distinctly between the two sexes. The association between age and urolithiasis presents distinct trends in the two sexes The results will provide evidence to explore the mechanisms underlying such differences can cast light on potential therapeutic targets and promote the development of tailored therapy strategies in prospect.
DOI: 10.6084/m9.figshare.21080443
title: Management guideline for the off-label use of medicine in China (2021)

description: Off-label drug use embodies a thorough clinical diagnosis and evaluation of treatment needs and should not be confused with unreasonable drug use, but it also faces potential risks with drug safety and legal issues. We first established a guideline working group. Following the guideline development process recommended by the World Health Organization Handbook and the Chinese Medical Association, the key questions were determined through literature searches of PubMed, CNKI (Chinese National Knowledge Infrastructure) and other databases. Both the evidence and the clinicians’ diagnosis and treatment workload were considered to formulate the initial recommendations. Finally, two rounds of Delphi surveys and one expert seminar were organized to determine the final recommendations of this guideline. Meanwhile, we graded the recommendations based on the body of evidence. We determined nine questions and proposed a total of 23 recommendations regarding the definition of off-label use of drugs, applicable circumstances, classification of evidence, informed consent, legal basis, adverse drug reaction monitoring and evaluation, management procedure, responsibilities and obligations of different stakeholders, medical insurance reimbursement, and the national approval system. This guideline standardized clinical off-label drug use and provided suggestions and references for the management of off-label drug use.
DOI: 10.6084/m9.figshare.20031618
title: Sex disparities and the risk of urolithiasis: a large cross-sectional study

description: Urolithiasis is one of the most common diseases in urology, with a lifetime prevalence of 14% and is more prevalent in males compared to females. We designed to explore sex disparities in the Chinese population to provide evidence for prevention measures and mechanisms of stone formation. A total of 98232 Chinese individuals who had undergone a comprehensive examination in 2017 were included. Fully adjusted odds ratios for kidney stones were measured using restricted cubic splines. Multiple imputations was applied for missing values. Propensity score matching was utilised for sensitivity analysis. Among the 98232 included participants, 42762 participants (43.53%) were females and 55470 participants (56.47%) were males. Patients’ factors might cast an influence on the development of kidney stone disease distinctly between the two genders. A risk factor for one gender might have no effect on the other gender. The risk for urolithiasis in females continuously rises as ageing, while for males the risk presents a trend to ascend until the age of around 53 and then descend. Patients’ factors might influence the development of kidney stones distinctly between the two genders. As age grew, the risk to develop kidney stones in females continuously ascended, while the risk in males presented a trend to ascend and then descend, which was presumably related to the weakening of the androgen signals.Key messagesWe found that patients’ factors might cast an influence on the development of kidney stone disease distinctly between the two sexes.The association between age and urolithiasis presents distinct trends in the two sexesThe results will provide evidence to explore the mechanisms underlying such differences can cast light on potential therapeutic targets and promote the development of tailored therapy strategies in prospect. We found that patients’ factors might cast an influence on the development of kidney stone disease distinctly between the two sexes. The association between age and urolithiasis presents distinct trends in the two sexes The results will provide evidence to explore the mechanisms underlying such differences can cast light on potential therapeutic targets and promote the development of tailored therapy strategies in prospect.
DOI: 10.6084/m9.figshare.21080511.v1
title: Prognosis of systemic inflammation at an early stage of cirrhosis using the monocyte-to-lymphocyte ratio during malnutrition risk screening: a prospective cohort study

description: To determine whether the monocyte-to-lymphocyte ratio (MLR), as a systemic inflammation index, predicts malnutrition risk during the early stages of cirrhosis. We conducted a single-center prospective cohort study, enrolling patients from June 2016 to September 2020. The patients underwent malnutrition risk assessments upon admission. The patients were classified into five clinical stages according to portal hypertension. The malnutrition risk was scored using the Royal Free Hospital-Nutritional Prioritizing Tool (RFH-NPT) and validated by the Nutritional Risk Screening 2002 (NRS-2002) or Liver Disease Undernutrition Screening Tool (LDUST). Routine clinical laboratory measurements were performed to calculate the MLR, Child–Turcotte–Pugh (CTP) class, and model for end-stage liver disease (MELD) score. The patients were followed up for 2 years. Among the 154 patients with cirrhosis, 60 had compensated cirrhosis and 94 had decompensated cirrhosis. The optimal cutoff value of the MLR, &gt;0.4, was effective in predicting malnutrition related to death or liver transplantation. Those with a high malnutrition risk defined by the NRS-2002 or RFH-NPT had a higher MLR than those with a low malnutrition risk. For patients with class A CTP cirrhosis or a MELD score of &lt;10, an MLR cutoff of &lt;0.4 significantly distinguished more patients with a low malnutrition risk than those with a high malnutrition risk. Both the RFH-NPT score and MLR increased significantly across the decompensated cirrhosis substages. Interestingly, the MLR exhibited a positive correlation with the RFH-NPT score until varices appeared, but the correlation was the highest at the substage of a history of variceal bleeding (r = 0.714, P = 0.009). Multivariable analysis demonstrated that an MLR of &gt;0.4 was an independent factor for malnutrition risk by screening with the RFH-NPT, and this was confirmed using the LDUST and NRS-2002. Immune-related inflammatory dysfunction predicts malnutrition risk during the early stages of cirrhosis.
DOI: 10.5285/3ba7bf8e-0118-4953-86b2-884028d062c4
title: High precision zircon U-Pb data for plutonic rocks from the Masirah and Ra's Madrakah ophiolites, South East Oman

description: Zircon U-Pb isotope data are presented for eight plutonic rocks from the Masirah ophiolite and one plutonic rock from the Ra's Madrakah ophiolite (South East Oman). These data constrain the age of formation of the two ophiolite nappes exposed on Masirah Island (early Cretaceous), whereas two intrusions with younger ages (late Cretaceous) overlap with the proposed emplacement age of the ophiolite. The data cover two sites in the Masirah Lower Nappe, two sites in the Masirah Upper Nappe (on Masirah Island, off the SE coast of Oman) and one site on Ra's Madrakah (on the mainland of Oman). 
Data collection was done using chemical abrasion isotope dilution thermal ionisation mass spectrometry (CA-ID-TIMS) at the NERC Isotope Geosciences Laboratories at the British geological Survey, supported by NERC Isotope Geosciences Facilities award IP-1919-0619. This work resulted from a PhD project funded by NERC GW4+ DTP grant NE/L002434/1.
DOI: 10.25387/g3.12691859
title: Supplemental Material for Tabima et al., 2020

description: Figure S1 contains maximum likelihood reconstruction of NRPS-A domains. Figure S2 contains graphical representation of cluster 5 from B. meristosporus CBS 931.73. Figure S3 contains phylogenetic sources and abundance of KS domains. Figure S4 contains maximum likelihood reconstruction of PKS KS domains. Figure S5 contains presence and absence of domains characteristic of PKS core gene models in non-zygomycete fungal species. Figure S6 contains presence and absence of domains characteristic of PKS core gene models in zygomycete fungal species. Figure S7 contains phylogenetic sources and abundance of terpene cyclases. Figure S8 includes the proof of concept for HGT assays. Figure S9 includes intron number comparisons for HGT genes. Figure S10 includes a PCA 5-mer analysis for HGT genes. Figure S11 includes a PCA for codon usage analysis for HGT genes. Figure S12 includes siderophore activity assays. Table S1 includes all Mucoromycota and Zoopagomycota isolates used in the manuscript. Table S2 is a summary of secondary metabolite genes predicted for Basidiobolus species. Table S3 includes the isolates of Dikarya used for the terpene cyclase assay. Table S4 includes the summary of hits of HGT genes against NBCI taxonomy. Table S5 is a summary of gene annotations from HGT candidates.