cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.8326010.v1
title: Box 1 code from Sampling to elucidate the dynamics of infections in reservoir hosts

description: The risk of zoonotic spillover from reservoir hosts, such as wildlife or domestic livestock, to people is shaped by the spatial and temporal distribution of infection in reservoir populations. Quantifying these distributions is a key challenge in epidemiology and disease ecology that requires researchers to make trade-offs between the extent and intensity of spatial versus temporal sampling. We discuss sampling methods that strengthen the reliability and validity of inferences about the dynamics of zoonotic pathogens in wildlife hosts.This article is part of the theme issue ‘Dynamic and integrative approaches to understanding pathogen spillover’.
DOI: 10.6084/m9.figshare.8326016.v1
title: Data from manuscript "Intraspecific perspective of phenotypic coordination of functional traits in Scots pine"

description: There are two spreadsheets with data. The "RAW DATA" spreadsheet contains raw trait data and the "TRANSF.DATA" contains transformed values for each trait used. Before raw data spreadsheet, there is a spreadsheet with the associated metadata, where a description of all the variables and units can be found.<br>
DOI: 10.6084/m9.figshare.8325998
title: Pilot implementation of co-designed software for co-production in mental health care planning: a qualitative evaluation of staff perspectives

description: <b>Background:</b> Mental health policies advocate service user participation in care planning. However, service users often feel they’re not fully involved and direct access to users’ own electronic care plans in the community can be an obstacle. To address this, an electronic care pathway tool (CPT) was co-designed by service users, staff and software developers, to facilitate co-production of care and crisis plans. <b>Aims:</b> To investigate the feasibility and acceptability of the pilot implementation of the CPT in professionals’ practice to co-produce care plans and enable efficient working. <b>Method:</b> Qualitative interviews with fifteen mental health practitioners, and five service development/management staff. Normalisation process theory, which outlines the social processes involved in implementing technology, and co-production theory, informed interviews and data analysis. <b>Results:</b> Multiple factors influenced CPT usage, including people’s views of technology, practitioners’ relationships with service users, service users’ mental health needs, and their capacity for reflective thinking. The CPT’s visual and interactive features could enable co-production of care plans. The CPT supported practitioners’ efficiency, but its features did not easily streamline with electronic patient records. <b>Conclusions:</b> CPT interactive touchpoints supported service users’ therapeutic reflection and facilitated care planning involvement. Information technology system interoperability was an obstacle.
DOI: 10.6084/m9.figshare.8325995
title: raw data

description: data
DOI: 10.6084/m9.figshare.8325989
title: data_for_R_analysis.txt

description: raw data
DOI: 10.6084/m9.figshare.8325998.v1
title: Pilot implementation of co-designed software for co-production in mental health care planning: a qualitative evaluation of staff perspectives

description: <b>Background:</b> Mental health policies advocate service user participation in care planning. However, service users often feel they’re not fully involved and direct access to users’ own electronic care plans in the community can be an obstacle. To address this, an electronic care pathway tool (CPT) was co-designed by service users, staff and software developers, to facilitate co-production of care and crisis plans. <b>Aims:</b> To investigate the feasibility and acceptability of the pilot implementation of the CPT in professionals’ practice to co-produce care plans and enable efficient working. <b>Method:</b> Qualitative interviews with fifteen mental health practitioners, and five service development/management staff. Normalisation process theory, which outlines the social processes involved in implementing technology, and co-production theory, informed interviews and data analysis. <b>Results:</b> Multiple factors influenced CPT usage, including people’s views of technology, practitioners’ relationships with service users, service users’ mental health needs, and their capacity for reflective thinking. The CPT’s visual and interactive features could enable co-production of care plans. The CPT supported practitioners’ efficiency, but its features did not easily streamline with electronic patient records. <b>Conclusions:</b> CPT interactive touchpoints supported service users’ therapeutic reflection and facilitated care planning involvement. Information technology system interoperability was an obstacle.
DOI: 10.6084/m9.figshare.8325995.v1
title: raw data

description: data
DOI: 10.6084/m9.figshare.8325989.v1
title: sandrini_rawdata.txt

description: raw data
DOI: 10.6084/m9.figshare.8325989.v2
title: R_analysis_data.txt

description: raw data
DOI: 10.6084/m9.figshare.8325824
title: Table S2. WT1-MACS peak calling results.xlsx

description: WT1-MACS peak calling results
DOI: 10.6084/m9.figshare.8325824.v1
title: Table S2. WT1-MACS peak calling results.xlsx

description: WT1-MACS peak calling results
DOI: 10.6084/m9.figshare.8325758
title: Experimental evolution serial transfer data all data

description: Weight and cell count measurements from fermentations within an experimental evolution regime.
DOI: 10.6084/m9.figshare.8325794
title: Supplementary Material for: Subcutaneous Magnesium Sulfate to Correct High-Output Ileostomy-Induced Hypomagnesemia

description: Fluid and magnesium abnormalities are common in patients with high-output stomas. Subcutaneous magnesium administration may be more feasible for long-term management in ambulatory patients, but magnesium sulfate is approved only for intravenous or intramuscular injection. We describe the management of chronic hypomagnesemia and dehydration secondary to a high-output ileostomy following radiation and chemotherapy for anal squamous cell carcinoma with intermittent home-based subcutaneous magnesium infusions in a 61-year-old female with a history of Crohn’s disease and multiple bowel resections. Despite aggressive management with intravenous magnesium sulfate and oral magnesium glucoheptonate over 8 months, 49% of her magnesium concentrations were &lt;0.60 mmol/L (mean 0.61 ± 0.09) necessitating 4 emergency, 1 hospital, and 4 infusion clinic visits. After initiation of subcutaneous magnesium sulfate, all magnesium concentrations were &gt;0.60 mmol/L (mean 0.79 ± 0.08 mmol/L over 9 months). The patient tolerated the infusions well, only developing one minor episode of infusion-related cellulitis. A systematic review of the literature identified 14 reports where subcutaneous magnesium sulfate<sub></sub>was effective and treatment for adults or children with hypomagnesemia was safe. Home-based intermittent administration of subcutaneous magnesium may be a helpful and safe intervention to temporarily prevent and treat select patients with recurrent symptomatic hypomagnesemia.
DOI: 10.6084/m9.figshare.8325794.v1
title: Supplementary Material for: Subcutaneous Magnesium Sulfate to Correct High-Output Ileostomy-Induced Hypomagnesemia

description: Fluid and magnesium abnormalities are common in patients with high-output stomas. Subcutaneous magnesium administration may be more feasible for long-term management in ambulatory patients, but magnesium sulfate is approved only for intravenous or intramuscular injection. We describe the management of chronic hypomagnesemia and dehydration secondary to a high-output ileostomy following radiation and chemotherapy for anal squamous cell carcinoma with intermittent home-based subcutaneous magnesium infusions in a 61-year-old female with a history of Crohn’s disease and multiple bowel resections. Despite aggressive management with intravenous magnesium sulfate and oral magnesium glucoheptonate over 8 months, 49% of her magnesium concentrations were &lt;0.60 mmol/L (mean 0.61 ± 0.09) necessitating 4 emergency, 1 hospital, and 4 infusion clinic visits. After initiation of subcutaneous magnesium sulfate, all magnesium concentrations were &gt;0.60 mmol/L (mean 0.79 ± 0.08 mmol/L over 9 months). The patient tolerated the infusions well, only developing one minor episode of infusion-related cellulitis. A systematic review of the literature identified 14 reports where subcutaneous magnesium sulfate<sub></sub>was effective and treatment for adults or children with hypomagnesemia was safe. Home-based intermittent administration of subcutaneous magnesium may be a helpful and safe intervention to temporarily prevent and treat select patients with recurrent symptomatic hypomagnesemia.
DOI: 10.6084/m9.figshare.8325758.v1
title: Experimental evolution serial transfer data all data

description: Weight and cell count measurements from fermentations within an experimental evolution regime.
DOI: 10.6084/m9.figshare.8325725
title: Supplementary Material for: Efficacy of Deep Brain Stimulation in a Patient with Genetically Confirmed Chorea-Acanthocytosis

description: Chorea-acanthocytosis (ChAc) is a rare autosomal recessive neurodegenerative disease due to mutation of the VPS13A gene encoding the protein chorein. ChAc is a slowly progressive disorder that typically presents in early adulthood, and whose clinical features include chorea and dystonia with involuntary lip, cheek, and tongue biting. Some patients also have seizures. Treatment for ChAc is symptomatic. A small number of ChAc patients have been treated with bilateral deep brain stimulation (DBS) of the globus pallidus interna (GPi), and we now present an additional case. Patient chart, functional measures, and laboratory findings were reviewed from the time of ChAc diagnosis until 6 months after DBS surgery. Here, we present a case of ChAc in a 31-year-old male positive for VPS13A gene mutations who presented with chorea, tongue biting, dysarthria, weight loss, and mild cognitive dysfunction. DBS using monopolar stimulation with placement slightly lateral to the GPi was associated with significant improvement in chorea and dysarthria. This case adds to the current state of knowledge regarding the efficacy and safety of bilateral GPi-DBS for symptomatic control of drug-resistant hyperkinetic movements seen in ChAc. Controlled trials are needed to better assess the impact and ideal target of DBS in ChAc.
DOI: 10.6084/m9.figshare.8325731
title: Additional File 2.doc

description: Clinical characteristics of the dengue NS1 patients (Day 1 – Day 5)
DOI: 10.6084/m9.figshare.8325731.v1
title: Additional File 2.doc

description: Clinical characteristics of the dengue NS1 patients (Day 1 – Day 5)
DOI: 10.6084/m9.figshare.8325716
title: 288-hour fermentations weight and cell count data.xlsx

description: Weight and cell count measurements from fermentations within an experimental evolution regime.
DOI: 10.6084/m9.figshare.8325722
title: Experimental evolution serial transfer data individual replicate files

description: Weight and cell count measurements taken during yest micro-fermentations.
DOI: 10.6084/m9.figshare.8325725.v1
title: Supplementary Material for: Efficacy of Deep Brain Stimulation in a Patient with Genetically Confirmed Chorea-Acanthocytosis

description: Chorea-acanthocytosis (ChAc) is a rare autosomal recessive neurodegenerative disease due to mutation of the VPS13A gene encoding the protein chorein. ChAc is a slowly progressive disorder that typically presents in early adulthood, and whose clinical features include chorea and dystonia with involuntary lip, cheek, and tongue biting. Some patients also have seizures. Treatment for ChAc is symptomatic. A small number of ChAc patients have been treated with bilateral deep brain stimulation (DBS) of the globus pallidus interna (GPi), and we now present an additional case. Patient chart, functional measures, and laboratory findings were reviewed from the time of ChAc diagnosis until 6 months after DBS surgery. Here, we present a case of ChAc in a 31-year-old male positive for VPS13A gene mutations who presented with chorea, tongue biting, dysarthria, weight loss, and mild cognitive dysfunction. DBS using monopolar stimulation with placement slightly lateral to the GPi was associated with significant improvement in chorea and dysarthria. This case adds to the current state of knowledge regarding the efficacy and safety of bilateral GPi-DBS for symptomatic control of drug-resistant hyperkinetic movements seen in ChAc. Controlled trials are needed to better assess the impact and ideal target of DBS in ChAc.
DOI: 10.6084/m9.figshare.8325722.v1
title: Experimental evolution serial transfer data individual replicate files

description: Weight and cell count measurements taken during yest micro-fermentations.
DOI: 10.6084/m9.figshare.8325680
title: Additional File 1 .doc

description: Age distribution of dengue NS1 antigen positive patients
DOI: 10.6084/m9.figshare.8325662
title: Supplementary Material for: Preoperative Thrombocytosis in Patients Undergoing Radical Cystectomy for Urothelial Cancer of the Bladder: An Independent Prognostic Parameter for an Impaired Oncological Outcome

description: <b><i>Background:</i></b> Preoperative thrombocytosis (PTC) is frequently observed in various solid malignancies and often associated with an unfavourable oncological outcome. <b><i>Objectives:</i></b> The aim of this study was to investigate the influence of PTC in patients undergoing radical cystectomy (RC) for urothelial carcinoma (UC) of the bladder on the oncological prognosis and additionally on perioperative blood transfusions (PBT). <b><i>Method:</i></b> A retrospective analysis of 866 patients undergoing RC in a tertiary care centre was performed. PTC was defined as a platelet count &gt;400 G/L. A chi-square test and Mann-Whitney test were used to investigate the association of PTC with categorical clinicopathological variables. A logrank test and multivariable Cox regression analyses were used to assess the association of PTC with cancer-specific survival. <b><i>Results:</i></b> PTC was detected in 8% (<i>n</i> = 67) of the patients and was significantly associated with muscle invasion (<i>p</i> = 0.004), advanced tumour stages (<i>p</i> = 0.003) and nodal metastases (<i>p</i> &lt; 0.001) and with a higher rate of PBT (<i>p</i>&lt; 0.001). In the multivariate analysis, PTC was significantly related to poor oncological survival (hazard ratio 2.23, 95% CI 1.51–3.30, <i>p</i> &lt; 0.001). <b><i>Conclusion:</i></b> PTC is significantly associated with an impaired oncological outcome in patients undergoing RC for UC. PTC therefore represents an independent and easy to determine prognostic parameter for patients’ oncological outcome. Intriguingly, PTC is significantly associated with an increased rate of PBT.
DOI: 10.6084/m9.figshare.8325662.v1
title: Supplementary Material for: Preoperative Thrombocytosis in Patients Undergoing Radical Cystectomy for Urothelial Cancer of the Bladder: An Independent Prognostic Parameter for an Impaired Oncological Outcome

description: <b><i>Background:</i></b> Preoperative thrombocytosis (PTC) is frequently observed in various solid malignancies and often associated with an unfavourable oncological outcome. <b><i>Objectives:</i></b> The aim of this study was to investigate the influence of PTC in patients undergoing radical cystectomy (RC) for urothelial carcinoma (UC) of the bladder on the oncological prognosis and additionally on perioperative blood transfusions (PBT). <b><i>Method:</i></b> A retrospective analysis of 866 patients undergoing RC in a tertiary care centre was performed. PTC was defined as a platelet count &gt;400 G/L. A chi-square test and Mann-Whitney test were used to investigate the association of PTC with categorical clinicopathological variables. A logrank test and multivariable Cox regression analyses were used to assess the association of PTC with cancer-specific survival. <b><i>Results:</i></b> PTC was detected in 8% (<i>n</i> = 67) of the patients and was significantly associated with muscle invasion (<i>p</i> = 0.004), advanced tumour stages (<i>p</i> = 0.003) and nodal metastases (<i>p</i> &lt; 0.001) and with a higher rate of PBT (<i>p</i>&lt; 0.001). In the multivariate analysis, PTC was significantly related to poor oncological survival (hazard ratio 2.23, 95% CI 1.51–3.30, <i>p</i> &lt; 0.001). <b><i>Conclusion:</i></b> PTC is significantly associated with an impaired oncological outcome in patients undergoing RC for UC. PTC therefore represents an independent and easy to determine prognostic parameter for patients’ oncological outcome. Intriguingly, PTC is significantly associated with an increased rate of PBT.
DOI: 10.6084/m9.figshare.8325623
title: ResultadosChile.csv

description: dataset
DOI: 10.6084/m9.figshare.8325626
title: ResultadosSalamanca.csv

description: dataset
DOI: 10.6084/m9.figshare.8325626.v1
title: ResultadosSalamanca.csv

description: dataset
DOI: 10.6084/m9.figshare.8325617
title: CuestionarioChile.txt

description: dataset
DOI: 10.6084/m9.figshare.8325623.v2
title: ResultadosChile.csv

description: dataset
DOI: 10.6084/m9.figshare.8325614
title: CuestionarioArgentina.txt

description: dataset
DOI: 10.6084/m9.figshare.8325611
title: CuestionarioSalamanca.txt

description: dataset
DOI: 10.6084/m9.figshare.8325617.v1
title: CuestionarioChile.txt

description: dataset
DOI: 10.6084/m9.figshare.8325623.v1
title: Chile.csv

description: dataset
DOI: 10.6084/m9.figshare.8325611.v1
title: CuestionarioSalamanca.txt

description: dataset
DOI: 10.6084/m9.figshare.8325614.v1
title: CuestionarioArgentina.txt

description: dataset
DOI: 10.6084/m9.figshare.8325569
title: Trpc5 deficiency causes hypoprolactinemia and altered function of oscillatory dopamine neurons in the arcuate nucleus

description: Repository file for PNAS publication concerning oscillatory firing behavior of dopamine neurons in the arcuate hypothalamic nucleus
DOI: 10.6084/m9.figshare.8325608
title: ResultadosArgentina.csv

description: Dataset
DOI: 10.6084/m9.figshare.8325569.v1
title: Trpc5 deficiency causes hypoprolactinemia and altered function of oscillatory dopamine neurons in the arcuate nucleus

description: Repository file for PNAS publication concerning oscillatory firing behavior of dopamine neurons in the arcuate hypothalamic nucleus
DOI: 10.6084/m9.figshare.8325551
title: INRIA-D3

description: INRIA
DOI: 10.6084/m9.figshare.8325608.v2
title: ResultadosArgentina.csv

description: Dataset
DOI: 10.6084/m9.figshare.8325497
title: The development of quality indicators for systemic lupus erythematosus using electronic health data: A modified RAND appropriateness method

description: <b>Objective:</b> Quality indicators (QIs) are tools that standardize evaluations in terms of the minimum acceptable quality of care, presumably contributing for the better management of patients with systemic lupus erythematosus (SLE). This study aimed to develop QIs for SLE using electronic health data. <b>Methods:</b> The modified RAND/UCLA Appropriateness Method was used to develop the QIs. First, a literature review was conducted. Second, the candidate QI items that were available to be evaluated using the electronic health data were extracted. Third, the appropriateness of the items was assessed via rating rounds and panelists’ discussions. <b>Results:</b> We found 3621 articles in the initial search. Finally, 34 studies were reviewed, from which 17 potential indicators were extracted as candidate QIs. Twelve indicators were selected as the final QI set through the process of appropriateness. The median appropriateness of these 12 indicators was at least 7.5, and all of them were without disagreement. The QI included assessment of disease activity, treatment of SLE, drug toxicity monitoring, treatment of glucocorticoid complications, and assessment of SLE complications. <b>Conclusion:</b> We formulated 12 QIs for the assessment of patients with SLE based on electronic medical data. Our QI set would be a practical tool as a quality measure.
DOI: 10.6084/m9.figshare.8325533
title: AIRS-D2

description: AIRS
DOI: 10.6084/m9.figshare.8325551.v1
title: INRIA-D3

description: INRIA
DOI: 10.6084/m9.figshare.8325608.v1
title: Argentina.csv

description: Dataset
DOI: 10.6084/m9.figshare.8325497.v1
title: The development of quality indicators for systemic lupus erythematosus using electronic health data: A modified RAND appropriateness method

description: <b>Objective:</b> Quality indicators (QIs) are tools that standardize evaluations in terms of the minimum acceptable quality of care, presumably contributing for the better management of patients with systemic lupus erythematosus (SLE). This study aimed to develop QIs for SLE using electronic health data. <b>Methods:</b> The modified RAND/UCLA Appropriateness Method was used to develop the QIs. First, a literature review was conducted. Second, the candidate QI items that were available to be evaluated using the electronic health data were extracted. Third, the appropriateness of the items was assessed via rating rounds and panelists’ discussions. <b>Results:</b> We found 3621 articles in the initial search. Finally, 34 studies were reviewed, from which 17 potential indicators were extracted as candidate QIs. Twelve indicators were selected as the final QI set through the process of appropriateness. The median appropriateness of these 12 indicators was at least 7.5, and all of them were without disagreement. The QI included assessment of disease activity, treatment of SLE, drug toxicity monitoring, treatment of glucocorticoid complications, and assessment of SLE complications. <b>Conclusion:</b> We formulated 12 QIs for the assessment of patients with SLE based on electronic medical data. Our QI set would be a practical tool as a quality measure.
DOI: 10.6084/m9.figshare.8325443
title: Avian influenza H9N2 subtype in Ghana: virus characterization and evidence of co-infection

description: Between November 2017 and February 2018, Ghanaian poultry producers reported to animal health authorities a dramatic increase in mortality rate and a relevant drop in egg production in several layer hen farms. Laboratory investigations revealed that the farms had been infected by the H9N2 influenza subtype. Virological and molecular characterization of the viruses identified in Ghana is described here for the first time. Whole genome analysis showed that the viruses belong to the G1-lineage and cluster with viruses identified in North and West Africa. The low pathogenicity of the virus was confirmed by the intravenous pathogenicity index assay. Further investigations revealed co-infection with infectious bronchitis virus of the GI-19 lineage, which very likely explained the severity of the disease observed during the outbreaks. The H9N2 outbreaks in Ghana highlight the importance of performing a differential diagnosis and an in-depth characterization of emerging viruses. In addition, the detection of a potentially zoonotic subtype, such as the H9N2, in a region where highly pathogenic avian influenza H5Nx is currently circulating highlights the urgency of implementing enhanced monitoring strategies and supporting improved investments in regional diagnostic technologies. <b>RESEARCH HIGHLIGHTS</b>Influenza A H9N2 subtype was detected in layer hens in Ghana in 2017–2018Whole genome characterization of seven H9N2 viruses was performedPhylogenetic trees revealed that the H9N2 viruses belong to the G1 lineageThe HA protein possesses the amino acid mutations 226L and 155TCo-infection with infectious bronchitis virus of the GI-19 lineage was identified Influenza A H9N2 subtype was detected in layer hens in Ghana in 2017–2018 Whole genome characterization of seven H9N2 viruses was performed Phylogenetic trees revealed that the H9N2 viruses belong to the G1 lineage The HA protein possesses the amino acid mutations 226L and 155T Co-infection with infectious bronchitis virus of the GI-19 lineage was identified