cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.19932326.v1
title: Seroprevalence of Toxoplasma gondii in domestic cats in tropical region of Serra da Tiririca State Park, Niterói, Rio de Janeiro

description: ABSTRACT The present study aimed to determine the seroprevalence of anti-T. gondii antibodies in cats of the Serra da Tiririca State Park region using the IFAT to evaluate the sex and age variables. The cats were domiciled in the region of Serra da Tiririca State Park (PESET-RJ), Rio de Janeiro. Between 2015 and 2016, a total of 86 blood samples were collected from 35 female and 51 male semi-domiciled cats that were attended to by a spay-neuter program of UFF. Samples were evaluated for anti-T. gondii immunoglobulin G by the indirect immunofluorescence reaction (IFAT) with a cut-off point of 1:40. Of the samples analyzed, 29.07% (25/86) presented anti-T gondii antibodies. There was no significant association (P&gt; 0.05) between the variables sex and age of the animals with serology results. The results obtained in this study suggest that T. gondii has a considerable distribution among the cats of the studied region (PESET-RJ). This is the first report of the seroprevalence of T. gondii in cats from this area. Age and gender were not considered risk factors for infection by T. gondii in this group of animals studied.
DOI: 10.6084/m9.figshare.19932357
title: Legal claims to obtain hip replacement surgery in the State of Rio de Janeiro, Brazil, 2016-2018

description: This study analyzed the court proceedings, health characteristics of the patients, and plaintiffs’ characteristics in lawsuits for hip replacement surgery from public health services in the state of Rio de Janeiro, Brazil. The data employed was from the Technical Support Center for the Judiciary of the Rio de Janeiro Court of Justice (NAT-JUS) database, from January 2016 to December 2018. Data were analyzed according to tiers in the court system. There were 89 lawsuits filed for hip replacement surgery and most of them were tried in the Court of Justice of the State of Rio de Janeiro (TJRJ), with joint plaintiffs, represented by the Public Defender’s Office. They had advance relief granted, and were ruled in favor of the plaintiffs, with no appeals filed. More than half of the cases were referred to NAT-JUS. The osteoarthritis group waited approximately seven months, while the emergency conditions group waited nearly two months from the date of filing to obtain the procedure. The lawsuits for hip replacement surgery showed similarities and differences in relation to other claims, object of others studies, which means that the strategies for their qualification. The study found that access to hip replacement surgery related to lawsuits in the Brazilian Unified National Health System (SUS) in the State of Rio de Janeiro is jeopardized, with the claims considered as an indicator of unmet needs
DOI: 10.6084/m9.figshare.19932357.v1
title: Legal claims to obtain hip replacement surgery in the State of Rio de Janeiro, Brazil, 2016-2018

description: This study analyzed the court proceedings, health characteristics of the patients, and plaintiffs’ characteristics in lawsuits for hip replacement surgery from public health services in the state of Rio de Janeiro, Brazil. The data employed was from the Technical Support Center for the Judiciary of the Rio de Janeiro Court of Justice (NAT-JUS) database, from January 2016 to December 2018. Data were analyzed according to tiers in the court system. There were 89 lawsuits filed for hip replacement surgery and most of them were tried in the Court of Justice of the State of Rio de Janeiro (TJRJ), with joint plaintiffs, represented by the Public Defender’s Office. They had advance relief granted, and were ruled in favor of the plaintiffs, with no appeals filed. More than half of the cases were referred to NAT-JUS. The osteoarthritis group waited approximately seven months, while the emergency conditions group waited nearly two months from the date of filing to obtain the procedure. The lawsuits for hip replacement surgery showed similarities and differences in relation to other claims, object of others studies, which means that the strategies for their qualification. The study found that access to hip replacement surgery related to lawsuits in the Brazilian Unified National Health System (SUS) in the State of Rio de Janeiro is jeopardized, with the claims considered as an indicator of unmet needs
DOI: 10.6084/m9.figshare.19932360
title: Lung cancer biomarkers. A literature review

description: ABSTRACT Lung cancer is the first in terms of incidence and mortality, being responsible worldwide for about 1.8 million deaths. In Brazil 31,270 new cases were diagnosed in 2018, 18,740 in men and 12,350 in women. One of the main challenges about lung cancer is performing an early diagnosis, in most cases the disease is detected in the late stages, which implies in poor prognoses. Tumor biomarkers are hugely relevant in early diagnosis, understanding of carcinogenesis, prognostic determination and therapeutic choice. The present paper reviews non-small cell lung cancer biomarkers described in the literature and their diagnostic, prognostic and therapeutic applications, intervention and therapeutic control for individualized therapy. Although there is still a vast universe to be explored, studies reveal a promising future for lung cancer treatment with increasingly personalized and assertive therapies that increase the chances of progression-free survival.
DOI: 10.6084/m9.figshare.19932360.v1
title: Lung cancer biomarkers. A literature review

description: ABSTRACT Lung cancer is the first in terms of incidence and mortality, being responsible worldwide for about 1.8 million deaths. In Brazil 31,270 new cases were diagnosed in 2018, 18,740 in men and 12,350 in women. One of the main challenges about lung cancer is performing an early diagnosis, in most cases the disease is detected in the late stages, which implies in poor prognoses. Tumor biomarkers are hugely relevant in early diagnosis, understanding of carcinogenesis, prognostic determination and therapeutic choice. The present paper reviews non-small cell lung cancer biomarkers described in the literature and their diagnostic, prognostic and therapeutic applications, intervention and therapeutic control for individualized therapy. Although there is still a vast universe to be explored, studies reveal a promising future for lung cancer treatment with increasingly personalized and assertive therapies that increase the chances of progression-free survival.
DOI: 10.6084/m9.figshare.19932381.v1
title: Effects of intravenous administration of allogeneic mesenchymal stromal cells, derived from adipose tissue, in five dogs with chronic kidney disease

description: ABSTRACT This study aimed to evaluate the safety of allogeneic adipose-derived mesenchymal stromal cell (aASC) treatment in dogs with chronic kidney disease (CKD) at the time of infusions and during the 120-day follow-up after the last infusion. Five dogs with CKD received three intravenous infusions of approximately 1×106?10% of aASCs per kilogram of body weight at 21-day intervals. Clinical and laboratory evaluations were performed at the time of each treatment and at 30 and 120 days after the last infusion. Adverse effects of the treatment were assessed using clinical observations, laboratory analyses, and owners’ answers about their dog’s behavior after infusions and during follow-up. The investigated animals did not present any adverse effects immediately after infusion or during the follow-up after the last infusion according to clinical and laboratory observations, as well as the dog owner’s descriptions. One treated animal showed a reduction in creatinine, from 3.5mg/dL to 2.4mg/dL from day 0 to day 153, gained 100g of body weight, and improved disposition. The study results demonstrate that aASC therapy is safe for dogs with CKD; however, further studies are needed to investigate these promising results.
DOI: 10.6084/m9.figshare.19932381
title: Effects of intravenous administration of allogeneic mesenchymal stromal cells, derived from adipose tissue, in five dogs with chronic kidney disease

description: ABSTRACT This study aimed to evaluate the safety of allogeneic adipose-derived mesenchymal stromal cell (aASC) treatment in dogs with chronic kidney disease (CKD) at the time of infusions and during the 120-day follow-up after the last infusion. Five dogs with CKD received three intravenous infusions of approximately 1×106?10% of aASCs per kilogram of body weight at 21-day intervals. Clinical and laboratory evaluations were performed at the time of each treatment and at 30 and 120 days after the last infusion. Adverse effects of the treatment were assessed using clinical observations, laboratory analyses, and owners’ answers about their dog’s behavior after infusions and during follow-up. The investigated animals did not present any adverse effects immediately after infusion or during the follow-up after the last infusion according to clinical and laboratory observations, as well as the dog owner’s descriptions. One treated animal showed a reduction in creatinine, from 3.5mg/dL to 2.4mg/dL from day 0 to day 153, gained 100g of body weight, and improved disposition. The study results demonstrate that aASC therapy is safe for dogs with CKD; however, further studies are needed to investigate these promising results.
DOI: 10.6084/m9.figshare.19932293.v1
title: Simulations of PEG-SH AuNPs

description: Supporting information for RSC Advances
DOI: 10.6084/m9.figshare.19932293
title: Simulations of PEG-SH AuNPs

description: Supporting information for RSC Advances
DOI: 10.6084/m9.figshare.19932455
title: Simulations of alkanethiol AuNPs

description: Supporting information for RSC Advances
DOI: 10.6084/m9.figshare.19932734
title: Supplementary Material for: Regional Cerebral Blood Flow Changes in Healthy Ageing and Alzheimer’s Disease: A Narrative Review

description: <b><i>Background:</i></b> Cerebral blood flow is known to decline with increasing age and is a potential biomarker to distinguish between healthy and unhealthy ageing, where healthy ageing is defined as an absence of comorbidities in senescence. This review aims to synthesize evidence of cerebral blood flow changes over multiple brain regions, for use as a clinical reference or for in silico modelling. <b><i>Summary:</i></b> The search identified 1,087 studies, of which 33 met the inclusion criteria to map the difference in cerebral blood flow reduction between healthy ageing and Alzheimer’s disease. Analysis was also performed on the effect of imaging modality and brain region functionality as potential confounding factors. <b><i>Key Messages:</i></b> No significant difference was found between the specific functionality of a brain region and cerebral blood flow in healthy ageing (<i>p</i> = 0.65) or Alzheimer’s disease (<i>p</i> = 0.42). Arterial spin labelling MRI imaging was shown to measure statistically larger decreases in flow in both healthy ageing (<i>p</i> = 0.0001) and Alzheimer’s disease (<i>p</i> = 0.0465). Cerebral blood flow was shown to decrease 0.3–0.5% per year in healthy ageing, which increased to a decline of 2–5% per year in Alzheimer’s disease. There was large variability both between and within individual brain regions, and this variability increased greatly in Alzheimer’s disease. Future studies would add value by taking more cerebral blood flow measurements during Alzheimer’s disease progression and by investigating ageing with comorbidities such as hypertension.
DOI: 10.6084/m9.figshare.13003345
title: The vicious cycle of functional neurological disorders: a synthesis of healthcare professionals’ views on working with patients with functional neurological disorder

description: The objective of this review was to synthesise studies which address the views of healthcare professionals (HCPs) towards patients with functional neurological disorder (FND). An interpretive systematised review was conducted. Seven databases were searched using a comprehensive search strategy (MEDLINE, EMBASE, AMED, CINAHL, PsychINFO, ProQuest Nursing and Allied Health, and Scopus). Qualitative studies and those using survey methods were included. An inductive approach to thematic analysis was used to identify concepts from the data and to synthesise the results. The views of 2769 HCPs were represented in 11 included articles. The overarching theme across the articles was uncertainty: about making the diagnosis of FND, about professional roles, and about optimum management. Fear was also a common theme: of saying the wrong thing, of offending patients, or of breaking the therapeutic relationship. If all HCPs felt uncertain about how to manage patients with FND and avoided them by passing them on to another discipline, then a “vicious cycle” is formed in which patients are passed from one professional to another but without receiving clear, honest information, or effective treatment. HCPs would benefit from increased training on FND and clear clinical pathways to alleviate feelings of uncertainty.Implications for rehabilitationEvidence-based or, at the very least, consensus-based multi-disciplinary care pathways for the assessment and treatment of patients with functional neurological disorder are required to improve equitability of services.Training packages for healthcare professionals need to be developed, evaluated and implemented in order to improve confidence of making and explaining the diagnosis and to reduce stigma of functional neurological disorders.Improved input for patients with functional neurological disorder is likely to occur if healthcare professionals are open, honest and use effective communication skills, both with their patients and fellow healthcare professionals. Evidence-based or, at the very least, consensus-based multi-disciplinary care pathways for the assessment and treatment of patients with functional neurological disorder are required to improve equitability of services. Training packages for healthcare professionals need to be developed, evaluated and implemented in order to improve confidence of making and explaining the diagnosis and to reduce stigma of functional neurological disorders. Improved input for patients with functional neurological disorder is likely to occur if healthcare professionals are open, honest and use effective communication skills, both with their patients and fellow healthcare professionals.
DOI: 10.6084/m9.figshare.13003345.v1
title: The vicious cycle of functional neurological disorders: a synthesis of healthcare professionals’ views on working with patients with functional neurological disorder

description: The objective of this review was to synthesise studies which address the views of healthcare professionals (HCPs) towards patients with functional neurological disorder (FND). An interpretive systematised review was conducted. Seven databases were searched using a comprehensive search strategy (MEDLINE, EMBASE, AMED, CINAHL, PsychINFO, ProQuest Nursing and Allied Health, and Scopus). Qualitative studies and those using survey methods were included. An inductive approach to thematic analysis was used to identify concepts from the data and to synthesise the results. The views of 2769 HCPs were represented in 11 included articles. The overarching theme across the articles was uncertainty: about making the diagnosis of FND, about professional roles, and about optimum management. Fear was also a common theme: of saying the wrong thing, of offending patients, or of breaking the therapeutic relationship. If all HCPs felt uncertain about how to manage patients with FND and avoided them by passing them on to another discipline, then a “vicious cycle” is formed in which patients are passed from one professional to another but without receiving clear, honest information, or effective treatment. HCPs would benefit from increased training on FND and clear clinical pathways to alleviate feelings of uncertainty.Implications for rehabilitationEvidence-based or, at the very least, consensus-based multi-disciplinary care pathways for the assessment and treatment of patients with functional neurological disorder are required to improve equitability of services.Training packages for healthcare professionals need to be developed, evaluated and implemented in order to improve confidence of making and explaining the diagnosis and to reduce stigma of functional neurological disorders.Improved input for patients with functional neurological disorder is likely to occur if healthcare professionals are open, honest and use effective communication skills, both with their patients and fellow healthcare professionals. Evidence-based or, at the very least, consensus-based multi-disciplinary care pathways for the assessment and treatment of patients with functional neurological disorder are required to improve equitability of services. Training packages for healthcare professionals need to be developed, evaluated and implemented in order to improve confidence of making and explaining the diagnosis and to reduce stigma of functional neurological disorders. Improved input for patients with functional neurological disorder is likely to occur if healthcare professionals are open, honest and use effective communication skills, both with their patients and fellow healthcare professionals.
DOI: 10.6084/m9.figshare.12949260
title: Effectiveness of manual therapy in patients with tension-type headache. A systematic review and meta-analysis

description: To systematically review the evidence about the effectiveness of manual therapy (MT) on pain intensity, frequency and impact of headache in individuals with tension-type headache (TTH). Medline, Embase, Scopus, Web of Science, CENTRAL, and PEDro were searched in June 2020. Randomized controlled trials that applied MT not associated with other interventions for TTH were selected. The level of evidence was synthesized using GRADE, and Standardized Mean Differences (SMD) were calculated for meta-analysis. Fifteen studies were included with a total sample of 1131 individuals. High velocity and low amplitude techniques were not superior to no treatment on reducing pain intensity (SMD = 0.01, low evidence) and frequency (SMD = −0.27, moderate evidence). Soft tissue interventions were superior to no treatment on reducing pain intensity (SMD = −0.86, low evidence) and frequency of pain (SMD = −1.45, low evidence). Dry needling was superior to no treatment on reducing pain intensity (SMD = −5.16, moderate evidence) and frequency (SMD = −2.14, moderate evidence). Soft tissue interventions were not superior to no treatment and other treatments on the impact of headache. Manual therapy may have positive effects on pain intensity and frequency, but more studies are necessary to strengthen the evidence of the effects of manual therapy on subjects with tension-type headache.Implications for rehabilitationSoft tissue interventions and dry needling can be used to improve pain intensity and frequency in patients with tension type headache.High velocity and low amplitude thrust manipulations were not effective for improving pain intensity and frequency in patients with tension type headache.Manual therapy was not effective for improving the impact of headache in patients with tension type headache. Soft tissue interventions and dry needling can be used to improve pain intensity and frequency in patients with tension type headache. High velocity and low amplitude thrust manipulations were not effective for improving pain intensity and frequency in patients with tension type headache. Manual therapy was not effective for improving the impact of headache in patients with tension type headache.
DOI: 10.6084/m9.figshare.13019414
title: Construct-concurrent validity and reliability of the European Child Environment Questionnaire (ECEQ) in a sample of Turkish children with cerebral palsy

description: To investigate the construct-concurrent validity and reliability of the Turkish version of the European Child Environment Questionnaire (ECEQ-T) in children with cerebral palsy (CP). Mean age 9.53 ± 4.45 years 306 children with CP and their parents participated in the study. While construct validity was assessed using confirmatory factor analysis, concurrent validity was investigated using the correlation between ECEQ-T and Pediatric Evaluation of Disability Inventory (PEDI) with Spearman’s correlation analysis. For test–retest reliability, ECEQ-T was administered twice to 65 parents with an interval of two weeks. Cronbach’s alpha (<i>α</i>) and Intraclass Correlation Coefficient (ICC) were used for reliability. Construct validity (RMSEA &gt; 0.080; GFI ≥ 0.90) and concurrent validity (<i>r</i>: −0.533 to −0.293; <i>p</i> α and ICC values were found (Cronbach <i>α</i><sub>PE</sub>: 0.960/ICC<sub>PE</sub>: 0.959, Cronbach <i>α</i><sub>SS</sub>: 0.955/ICC<sub>SS</sub>: 0.954), Cronbach <i>α</i><sub>A</sub>: 0.822/ICC<sub>A</sub>: 0.802, Cronbach <i>α</i><sub>T</sub>: 0.957/ICC<sub>T</sub>: 0.955). ECEQ-T has demonstrated good psychometric properties and can be used as a reliable and valid measure to assess environmental factors. We believe that ECEQ-T is a useful and detailed questionnaire to determine barriers-facilitators for increasing activity and participation in Turkish children with CP.IMPLICATIONS FOR REHABILITATIONThe Turkish version of ECEQ has acceptable construct validity and moderate concurrent validity for evaluating environmental factors in children with cerebral palsy.The Turkish version of ECEQ provides valuable information, which could be helpful to guide public health services and government policies in order to optimize the participation of children with CP.Environmental factors may play an important role in activity and participation in children with cerebral palsy. Turkish version of the ECEQ can be used for evaluating the environmental factors to determine barriers of activity and participation. The Turkish version of ECEQ has acceptable construct validity and moderate concurrent validity for evaluating environmental factors in children with cerebral palsy. The Turkish version of ECEQ provides valuable information, which could be helpful to guide public health services and government policies in order to optimize the participation of children with CP. Environmental factors may play an important role in activity and participation in children with cerebral palsy. Turkish version of the ECEQ can be used for evaluating the environmental factors to determine barriers of activity and participation.