cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.1408477
title: Fumonisins B<sub>1</sub>, B<sub>2</sub> and B<sub>3</sub> in corn products, wheat flour and corn oil marketed in Shandong province of China

description: In this study a total of 522 samples were collected from Shandong province of China in 2014 and analysed for the occurrence of fumonisin B1 (FB<sub>1</sub>), FB<sub>2</sub> and FB<sub>3</sub> by isotope dilution ultrahigh performance liquid chromatography–tandem mass spectrometry. Fumonisins were detected in 98.1% of the corn products, with the average total level of 369.2 μg kg<sup>−1</sup>. The individual average values of FB<sub>1</sub>, FB<sub>2</sub> and FB<sub>3</sub> in corn products were 268.3, 53.7 and 47.2 μg kg<sup>−1</sup>, respectively. The simultaneous occurrence of FB<sub>1</sub>, FB<sub>2</sub> and FB<sub>3</sub> was observed in 76.7% of the corn products. Especially, the results demonstrated that the difference in the contamination levels for fumonisins in these three types of corn products was apparent. In addition, 6.2% of the wheat flour samples were contaminated with FB<sub>1</sub>, with concentrations ranging from 0.3 to 34.6 µg kg<sup>−1</sup>. No FB<sub>2</sub> or FB<sub>3</sub> was detected in wheat flour. In corn oil samples no fumonisins were detected.
DOI: 10.6084/m9.figshare.1408477.v1
title: Fumonisins B<sub>1</sub>, B<sub>2</sub> and B<sub>3</sub> in corn products, wheat flour and corn oil marketed in Shandong province of China

description: In this study a total of 522 samples were collected from Shandong province of China in 2014 and analysed for the occurrence of fumonisin B1 (FB<sub>1</sub>), FB<sub>2</sub> and FB<sub>3</sub> by isotope dilution ultrahigh performance liquid chromatography–tandem mass spectrometry. Fumonisins were detected in 98.1% of the corn products, with the average total level of 369.2 μg kg<sup>−1</sup>. The individual average values of FB<sub>1</sub>, FB<sub>2</sub> and FB<sub>3</sub> in corn products were 268.3, 53.7 and 47.2 μg kg<sup>−1</sup>, respectively. The simultaneous occurrence of FB<sub>1</sub>, FB<sub>2</sub> and FB<sub>3</sub> was observed in 76.7% of the corn products. Especially, the results demonstrated that the difference in the contamination levels for fumonisins in these three types of corn products was apparent. In addition, 6.2% of the wheat flour samples were contaminated with FB<sub>1</sub>, with concentrations ranging from 0.3 to 34.6 µg kg<sup>−1</sup>. No FB<sub>2</sub> or FB<sub>3</sub> was detected in wheat flour. In corn oil samples no fumonisins were detected.
DOI: 10.6084/m9.figshare.1408477.v2
title: Fumonisins B<sub>1</sub>, B<sub>2</sub> and B<sub>3</sub> in corn products, wheat flour and corn oil marketed in Shandong province of China

description: In this study a total of 522 samples were collected from Shandong province of China in 2014 and analysed for the occurrence of fumonisin B1 (FB<sub>1</sub>), FB<sub>2</sub> and FB<sub>3</sub> by isotope dilution ultrahigh performance liquid chromatography–tandem mass spectrometry. Fumonisins were detected in 98.1% of the corn products, with the average total level of 369.2 μg kg<sup>−1</sup>. The individual average values of FB<sub>1</sub>, FB<sub>2</sub> and FB<sub>3</sub> in corn products were 268.3, 53.7 and 47.2 μg kg<sup>−1</sup>, respectively. The simultaneous occurrence of FB<sub>1</sub>, FB<sub>2</sub> and FB<sub>3</sub> was observed in 76.7% of the corn products. Especially, the results demonstrated that the difference in the contamination levels for fumonisins in these three types of corn products was apparent. In addition, 6.2% of the wheat flour samples were contaminated with FB<sub>1</sub>, with concentrations ranging from 0.3 to 34.6 µg kg<sup>−1</sup>. No FB<sub>2</sub> or FB<sub>3</sub> was detected in wheat flour. In corn oil samples no fumonisins were detected.
DOI: 10.6084/m9.figshare.1408477.v3
title: Fumonisins B<sub>1</sub>, B<sub>2</sub> and B<sub>3</sub> in corn products, wheat flour and corn oil marketed in Shandong province of China

description: In this study a total of 522 samples were collected from Shandong province of China in 2014 and analysed for the occurrence of fumonisin B1 (FB<sub>1</sub>), FB<sub>2</sub> and FB<sub>3</sub> by isotope dilution ultrahigh performance liquid chromatography–tandem mass spectrometry. Fumonisins were detected in 98.1% of the corn products, with the average total level of 369.2 μg kg<sup>−1</sup>. The individual average values of FB<sub>1</sub>, FB<sub>2</sub> and FB<sub>3</sub> in corn products were 268.3, 53.7 and 47.2 μg kg<sup>−1</sup>, respectively. The simultaneous occurrence of FB<sub>1</sub>, FB<sub>2</sub> and FB<sub>3</sub> was observed in 76.7% of the corn products. Especially, the results demonstrated that the difference in the contamination levels for fumonisins in these three types of corn products was apparent. In addition, 6.2% of the wheat flour samples were contaminated with FB<sub>1</sub>, with concentrations ranging from 0.3 to 34.6 µg kg<sup>−1</sup>. No FB<sub>2</sub> or FB<sub>3</sub> was detected in wheat flour. In corn oil samples no fumonisins were detected.
DOI: 10.6084/m9.figshare.1408477.v4
title: Fumonisins B<sub>1</sub>, B<sub>2</sub> and B<sub>3</sub> in corn products, wheat flour and corn oil marketed in Shandong province of China

description: In this study a total of 522 samples were collected from Shandong province of China in 2014 and analysed for the occurrence of fumonisin B1 (FB<sub>1</sub>), FB<sub>2</sub> and FB<sub>3</sub> by isotope dilution ultrahigh performance liquid chromatography–tandem mass spectrometry. Fumonisins were detected in 98.1% of the corn products, with the average total level of 369.2 μg kg<sup>−1</sup>. The individual average values of FB<sub>1</sub>, FB<sub>2</sub> and FB<sub>3</sub> in corn products were 268.3, 53.7 and 47.2 μg kg<sup>−1</sup>, respectively. The simultaneous occurrence of FB<sub>1</sub>, FB<sub>2</sub> and FB<sub>3</sub> was observed in 76.7% of the corn products. Especially, the results demonstrated that the difference in the contamination levels for fumonisins in these three types of corn products was apparent. In addition, 6.2% of the wheat flour samples were contaminated with FB<sub>1</sub>, with concentrations ranging from 0.3 to 34.6 µg kg<sup>−1</sup>. No FB<sub>2</sub> or FB<sub>3</sub> was detected in wheat flour. In corn oil samples no fumonisins were detected.
DOI: 10.6084/m9.figshare.1408711
title: Comparison of Retinal Thickness Measurements between the Topcon Algorithm and a Graph-Based Algorithm in Normal and Glaucoma Eyes

description: The manuscript was accepted by journal "PLoS ONE" under the title of
"Comparison of Retinal Thickness Measurements between the Topcon Algorithm and a Graph-Based Algorithm in Normal and Glaucoma Eyes", with a doi of 10.1371/journal.pone.0128925
DOI: 10.6084/m9.figshare.1408711.v1
title: Comparison of Retinal Thickness Measurements between the Topcon Algorithm and a Graph-Based Algorithm in Normal and Glaucoma Eyes

description: The manuscript was accepted by journal "PLoS ONE" under the title of
"Comparison of Retinal Thickness Measurements between the Topcon Algorithm and a Graph-Based Algorithm in Normal and Glaucoma Eyes", with a doi of 10.1371/journal.pone.0128925
DOI: 10.6084/m9.figshare.1408711.v2
title: Comparison of Retinal Thickness Measurements between the Topcon Algorithm and a Graph-Based Algorithm in Normal and Glaucoma Eyes

description: The manuscript was accepted by journal "PLoS ONE" under the title of
"Comparison of Retinal Thickness Measurements between the Topcon Algorithm and a Graph-Based Algorithm in Normal and Glaucoma Eyes", with a doi of 10.1371/journal.pone.0128925
DOI: 10.6084/m9.figshare.1408711.v3
title: Comparison of Retinal Thickness Measurements between the Topcon Algorithm and a Graph-Based Algorithm in Normal and Glaucoma Eyes

description: The manuscript was accepted by journal "PLoS ONE" under the title of
"Comparison of Retinal Thickness Measurements between the Topcon Algorithm and a Graph-Based Algorithm in Normal and Glaucoma Eyes", with a doi of 10.1371/journal.pone.0128925
DOI: 10.6084/m9.figshare.1408711.v5
title: Comparison of Retinal Thickness Measurements between the Topcon Algorithm and a Graph-Based Algorithm in Normal and Glaucoma Eyes

description: The manuscript was accepted by journal "PLoS ONE" under the title of
"Comparison of Retinal Thickness Measurements between the Topcon Algorithm and a Graph-Based Algorithm in Normal and Glaucoma Eyes", with a doi of 10.1371/journal.pone.0128925
DOI: 10.6084/m9.figshare.1408711.v4
title: Comparison of Retinal Thickness Measurements between the Topcon Algorithm and a Graph-Based Algorithm in Normal and Glaucoma Eyes

description: The manuscript was accepted by journal "PLoS ONE" under the title of
"Comparison of Retinal Thickness Measurements between the Topcon Algorithm and a Graph-Based Algorithm in Normal and Glaucoma Eyes", with a doi of 10.1371/journal.pone.0128925
DOI: 10.6084/m9.figshare.1409462
title: Analysis of DNA methylation and gene expression in radiation-resistant head and neck tumors

description: Resistance to radiation therapy constitutes a significant challenge in the treatment of head and neck squamous cell cancer (HNSCC). Alteration in DNA methylation is thought to play a role in this resistance. Here, we analyzed DNA methylation changes in a matched model of radiation resistance for HNSCC using the Illumina HumanMethylation450 BeadChip. Our results show that compared to radiation-sensitive cells (SCC-61), radiation-resistant cells (rSCC-61) had a significant increase in DNA methylation. After combining these results with microarray gene expression data, we identified 84 differentially methylated and expressed genes between these 2 cell lines. Ingenuity Pathway Analysis revealed ILK signaling, glucocorticoid receptor signaling, fatty acid α-oxidation, and cell cycle regulation as top canonical pathways associated with radiation resistance. Validation studies focused on CCND2, a protein involved in cell cycle regulation, which was identified as hypermethylated in the promoter region and downregulated in rSCC-61 relative to SCC-61 cells. Treatment of rSCC-61 and SCC-61 with the DNA hypomethylating agent 5-aza-2'deoxycitidine increased CCND2 levels only in rSCC-61 cells, while treatment with the control reagent cytosine arabinoside did not influence the expression of this gene. Further analysis of HNSCC data from The Cancer Genome Atlas found increased methylation in radiation-resistant tumors, consistent with the cell culture data. Our findings point to global DNA methylation status as a biomarker of radiation resistance in HNSCC, and suggest a need for targeted manipulation of DNA methylation to increase radiation response in HNSCC.
DOI: 10.6084/m9.figshare.1409462.v1
title: Analysis of DNA Methylation and Gene Expression in Radiation-Resistant Head and Neck Tumors

description: Resistance to radiation therapy constitutes a significant challenge in the treatment of head and neck squamous cell cancer (HNSCC). Alteration in DNA methylation is thought to play a role in this resistance. Here, we analyzed DNA methylation changes in a matched model of radiation resistance for HNSCC using the Illumina HumanMethylation450 BeadChip. Our results show that compared to radiation- sensitive cells (SCC-61), radiation-resistant cells (rSCC-61) had a significant increase in DNA methylation. After combining these results with microarray gene expression data, we identified 90 differentially methylated and expressed genes between these two cell lines. Ingenuity Pathway Analysis revealed ILK signaling, glucocorticoid receptor signaling, fatty acid α-oxidation, and cell cycle regulation as top canonical pathways associated with radiation resistance. Validation studies focused on CCND2, a protein involved in cell cycle regulation, which was identified as hypermethylated in the promoter region and downregulated in rSCC-61 relative to SCC-61 cells. Treatment of rSCC-61 and SCC-61 with the DNA hypomethylating agent 5-aza-2′deoxycitidine increased CCND2 levels only in rSCC-61 cells, while treatment with the control reagent cytosine arabinoside did not influence the expression of this gene. Further analysis of HNSCC data from The Cancer Genome Atlas found increased methylation in radiation-resistant tumors, consistent with the cell culture data. Our findings point to global DNA methylation status as a biomarker of radiation resistance in HNSCC, and suggest a need for targeted manipulation of DNA methylation to increase radiation response in HNSCC.
DOI: 10.6084/m9.figshare.1409462.v2
title: Analysis of DNA methylation and gene expression in radiation-resistant head and neck tumors

description: Resistance to radiation therapy constitutes a significant challenge in the treatment of head and neck squamous cell cancer (HNSCC). Alteration in DNA methylation is thought to play a role in this resistance. Here, we analyzed DNA methylation changes in a matched model of radiation resistance for HNSCC using the Illumina HumanMethylation450 BeadChip. Our results show that compared to radiation-sensitive cells (SCC-61), radiation-resistant cells (rSCC-61) had a significant increase in DNA methylation. After combining these results with microarray gene expression data, we identified 84 differentially methylated and expressed genes between these 2 cell lines. Ingenuity Pathway Analysis revealed ILK signaling, glucocorticoid receptor signaling, fatty acid α-oxidation, and cell cycle regulation as top canonical pathways associated with radiation resistance. Validation studies focused on CCND2, a protein involved in cell cycle regulation, which was identified as hypermethylated in the promoter region and downregulated in rSCC-61 relative to SCC-61 cells. Treatment of rSCC-61 and SCC-61 with the DNA hypomethylating agent 5-aza-2'deoxycitidine increased CCND2 levels only in rSCC-61 cells, while treatment with the control reagent cytosine arabinoside did not influence the expression of this gene. Further analysis of HNSCC data from The Cancer Genome Atlas found increased methylation in radiation-resistant tumors, consistent with the cell culture data. Our findings point to global DNA methylation status as a biomarker of radiation resistance in HNSCC, and suggest a need for targeted manipulation of DNA methylation to increase radiation response in HNSCC.
DOI: 10.6084/m9.figshare.1409462.v4
title: Analysis of DNA methylation and gene expression in radiation-resistant head and neck tumors

description: Resistance to radiation therapy constitutes a significant challenge in the treatment of head and neck squamous cell cancer (HNSCC). Alteration in DNA methylation is thought to play a role in this resistance. Here, we analyzed DNA methylation changes in a matched model of radiation resistance for HNSCC using the Illumina HumanMethylation450 BeadChip. Our results show that compared to radiation-sensitive cells (SCC-61), radiation-resistant cells (rSCC-61) had a significant increase in DNA methylation. After combining these results with microarray gene expression data, we identified 84 differentially methylated and expressed genes between these 2 cell lines. Ingenuity Pathway Analysis revealed ILK signaling, glucocorticoid receptor signaling, fatty acid α-oxidation, and cell cycle regulation as top canonical pathways associated with radiation resistance. Validation studies focused on CCND2, a protein involved in cell cycle regulation, which was identified as hypermethylated in the promoter region and downregulated in rSCC-61 relative to SCC-61 cells. Treatment of rSCC-61 and SCC-61 with the DNA hypomethylating agent 5-aza-2'deoxycitidine increased CCND2 levels only in rSCC-61 cells, while treatment with the control reagent cytosine arabinoside did not influence the expression of this gene. Further analysis of HNSCC data from The Cancer Genome Atlas found increased methylation in radiation-resistant tumors, consistent with the cell culture data. Our findings point to global DNA methylation status as a biomarker of radiation resistance in HNSCC, and suggest a need for targeted manipulation of DNA methylation to increase radiation response in HNSCC.
DOI: 10.6084/m9.figshare.1409462.v3
title: Analysis of DNA methylation and gene expression in radiation-resistant head and neck tumors

description: Resistance to radiation therapy constitutes a significant challenge in the treatment of head and neck squamous cell cancer (HNSCC). Alteration in DNA methylation is thought to play a role in this resistance. Here, we analyzed DNA methylation changes in a matched model of radiation resistance for HNSCC using the Illumina HumanMethylation450 BeadChip. Our results show that compared to radiation-sensitive cells (SCC-61), radiation-resistant cells (rSCC-61) had a significant increase in DNA methylation. After combining these results with microarray gene expression data, we identified 84 differentially methylated and expressed genes between these 2 cell lines. Ingenuity Pathway Analysis revealed ILK signaling, glucocorticoid receptor signaling, fatty acid α-oxidation, and cell cycle regulation as top canonical pathways associated with radiation resistance. Validation studies focused on CCND2, a protein involved in cell cycle regulation, which was identified as hypermethylated in the promoter region and downregulated in rSCC-61 relative to SCC-61 cells. Treatment of rSCC-61 and SCC-61 with the DNA hypomethylating agent 5-aza-2'deoxycitidine increased CCND2 levels only in rSCC-61 cells, while treatment with the control reagent cytosine arabinoside did not influence the expression of this gene. Further analysis of HNSCC data from The Cancer Genome Atlas found increased methylation in radiation-resistant tumors, consistent with the cell culture data. Our findings point to global DNA methylation status as a biomarker of radiation resistance in HNSCC, and suggest a need for targeted manipulation of DNA methylation to increase radiation response in HNSCC.
DOI: 10.6084/m9.figshare.1414164
title: Provenance of detrital zircons in the Late Triassic Sichuan foreland basin: constraints on the evolution of the Qinling Orogen and Longmen Shan thrust-fold belt in central China

description: In this article, we present <i>in situ</i> U–Pb and Lu–Hf isotope data for Upper Triassic detritus in the Sichuan region of northwestern South China, which was a foreland basin during the Late Triassic. The aim is to determine the provenance of sediments in the foreland basin and to constrain the evolution of the surrounding mountain belts. U–Pb age data for the Late Triassic detrital zircons generally show populations at 2.4–2.6 Ga, 1.7–1.9 Ga, 710–860 Ma, 410–460 Ma, and 210–300 Ma. By fitting the zircon data into the tectonic, sedimentologic, and palaeographic framework, we propose that the north Yangtze Block and South Qinling–Dabie Orogen were the important source areas of sediments in the northern part of the foreland basin, whereas the Longmen Shan thrust-fold belt was the main source region for detritus in other parts of the foreland basin. The South Qinling–Dabie Orogen could also have served as a physical barrier to block most detritus shed from the southern North China Block into the foreland basin during the sedimentation of the Xujiahe Formation. Our results also reveal that part of the flysch from the eastern margin of the Songpan–Ganzi region had been displaced into the Longmen Shan thrust-fold belt before the deposition of the foreland basin sediments. In addition, the Lu-Hf data indicate that Phanerozoic igneous rocks in central China show insignificant formation of the juvenile crust.
DOI: 10.6084/m9.figshare.1414164.v1
title: Provenance of detrital zircons in the Late Triassic Sichuan foreland basin: constraints on the evolution of the Qinling Orogen and Longmen Shan thrust-fold belt in central China

description: In this article, we present <i>in situ</i> U–Pb and Lu–Hf isotope data for Upper Triassic detritus in the Sichuan region of northwestern South China, which was a foreland basin during the Late Triassic. The aim is to determine the provenance of sediments in the foreland basin and to constrain the evolution of the surrounding mountain belts. U–Pb age data for the Late Triassic detrital zircons generally show populations at 2.4–2.6 Ga, 1.7–1.9 Ga, 710–860 Ma, 410–460 Ma, and 210–300 Ma. By fitting the zircon data into the tectonic, sedimentologic, and palaeographic framework, we propose that the north Yangtze Block and South Qinling–Dabie Orogen were the important source areas of sediments in the northern part of the foreland basin, whereas the Longmen Shan thrust-fold belt was the main source region for detritus in other parts of the foreland basin. The South Qinling–Dabie Orogen could also have served as a physical barrier to block most detritus shed from the southern North China Block into the foreland basin during the sedimentation of the Xujiahe Formation. Our results also reveal that part of the flysch from the eastern margin of the Songpan–Ganzi region had been displaced into the Longmen Shan thrust-fold belt before the deposition of the foreland basin sediments. In addition, the Lu-Hf data indicate that Phanerozoic igneous rocks in central China show insignificant formation of the juvenile crust.
DOI: 10.6084/m9.figshare.1414164.v2
title: Provenance of detrital zircons in the Late Triassic Sichuan foreland basin: constraints on the evolution of the Qinling Orogen and Longmen Shan thrust-fold belt in central China

description: In this article, we present <i>in situ</i> U–Pb and Lu–Hf isotope data for Upper Triassic detritus in the Sichuan region of northwestern South China, which was a foreland basin during the Late Triassic. The aim is to determine the provenance of sediments in the foreland basin and to constrain the evolution of the surrounding mountain belts. U–Pb age data for the Late Triassic detrital zircons generally show populations at 2.4–2.6 Ga, 1.7–1.9 Ga, 710–860 Ma, 410–460 Ma, and 210–300 Ma. By fitting the zircon data into the tectonic, sedimentologic, and palaeographic framework, we propose that the north Yangtze Block and South Qinling–Dabie Orogen were the important source areas of sediments in the northern part of the foreland basin, whereas the Longmen Shan thrust-fold belt was the main source region for detritus in other parts of the foreland basin. The South Qinling–Dabie Orogen could also have served as a physical barrier to block most detritus shed from the southern North China Block into the foreland basin during the sedimentation of the Xujiahe Formation. Our results also reveal that part of the flysch from the eastern margin of the Songpan–Ganzi region had been displaced into the Longmen Shan thrust-fold belt before the deposition of the foreland basin sediments. In addition, the Lu-Hf data indicate that Phanerozoic igneous rocks in central China show insignificant formation of the juvenile crust.