cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.23600799.v2
title: Eco-friendly postharvest irradiation strategy with <sup>131</sup>I isotope for environmental management of populations of migratory locust, <i>Locusta migratoria</i>

description: Irradiation of food is promising for control of pests to minimize postharvest losses of yields and thus improvement of food safety, shelf life of produce. It is a method of choice that induces a series of lethal biochemical and molecular changes culminating into the engagement of a downstream cascade to cause abnormalities in irradiated pests. In this study, the effects of iodine-131 (<sup>131</sup>I) isotope radiation on the male gonad development of the migratory locust, <i>Locusta migratoria,</i> were evaluated. Newly emerged adult male locusts, less than one-day-old, were divided into two groups, control and irradiated. Locusts in the control group (<i>n</i> = 20 insects) didn’t drink irradiated water and were reared under normal environmental conditions for one week. Locusts in the irradiated group (<i>n</i> = 20 insects) were exposed to irradiated water at a dose of 30 mCi and they were subsequently observed until they drank the whole quantity. At the end of the experiment, scanning and electron microscopic examination of testes obtained from irradiated locusts revealed several major abnormalities, including malformed nuclei of spermatozoa, irregular plasma membranes, shrinkage of testicular follicles, vacuolated cytoplasm, disintegrated nebenkern and agglutinations of spermatids. Flow cytometry analysis revealed that <sup>131</sup>I radiation induced both early and late apoptosis, but not necrosis, in testicular tissues. Testes of irradiated insects also exhibited a burst in reactive oxygen species (ROS), as indicated by significant elevation in amounts of malondialdehyde (MDA), a marker for peroxidation of lipids. In contrast, irradiation coincided with significant reductions in activities of enzymatic antioxidant biomarkers. Relative to controls, a three-fold upregulation of expression of mRNA of heat shock protein, <i>Hsp90</i>, was observed in testicular tissue of irradiated locusts. <sup>131</sup>I-irradiated insects exhibited genotoxicity, as indicated by significant increases in various indicators of DNA damage by the comet assay, including tail length (7.80 ± 0.80 µm; <i>p</i> &lt; .01), olive tail moment (40.37 ± 8.08; <i>p</i> &lt; .01) and tail DNA intensity % (5.1 ± 0.51; <i>p</i> &lt; .01), in testicular cells compared to the controls. This is the first report on elucidation of I<sup>131</sup>-irradiation-mediated histopathological, biochemical and molecular mechanisms in gonads of male <i>L. migratoria.</i> Herein, the findings underscore the utility of <sup>131</sup>I radiation as an eco-friendly postharvest strategy for management of insect pests and in particular for control of populations of <i>L. migratoria</i>.
DOI: 10.6084/m9.figshare.23609129
title: The effects of PKI-402 on breast tumor models’ radiosensitivity via dual inhibition of PI3K/mTOR

description: PI3K/Akt/mTOR pathway activation causes relapse and resistance after radiotherapy in breast cancer (BC). We aimed to radiosensitize BC cell lines to irradiation (IR) by PKI-402, a dual PI3K/mTOR inhibitor. We performed cytotoxicity, clonogenicity, hanging drop, apoptosis and double-strand break detection, and phosphorylation of 16 essential proteins involved in the PI3K/mTOR pathway. Our findings showed that PKI-402 has cytotoxic efficiency in all cell lines. Clonogenic assay results showed that PKI-402 plus IR inhibited the colony formation ability of MCF-7 and breast cancer stem cell lines. Results showed that PKI-402 plus IR causes more apoptotic cell death than IR alone in the MCF-7 cells but did not cause significant changes in the MDA-MB-231. γ-H2AX levels were increased in MDA-MB-231 in PKI-402 plus IR groups, whereas we did not observe any apoptotic and γ-H2AX induction in BCSCs and MCF-10A cells in all treatment groups. Some pivotal phosphorylated proteins of the PI3K/AKT pathway decreased, several proteins increased and others did not change. In conclusion, if the combined use of PKI-402 with radiation is supported by in vivo studies, it can contribute to the treatment options and the course of the disease.
DOI: 10.6084/m9.figshare.23902302
title: Candidate biomarkers and persistent transcriptional responses after low and high dose ionizing radiation at high dose rate

description: Development of an integrated time and dose model to explore the dynamics of gene expression alterations and identify biomarkers for biodosimetry following low- and high-dose irradiations at high dose rate. We utilized multiple transcriptome datasets (GSE8917, GSE43151, and GSE23515) from Gene Expression Omnibus (GEO) for identifying candidate biological dosimeters. A linear mixed-effects model with random intercept was used to explore the dose-time dynamics of transcriptional responses and to functionally characterize the time- and dose-dependent changes in gene expression. We identified genes that are correlated with dose and time and discovered two clusters of genes that are either positively or negatively correlated with both dose and time based on the parameters of the model. Genes in these two clusters may have persistent transcriptional alterations. Twelve potential transcriptional markers for dosimetry—ARHGEF3, BAX, BBC3, CCDC109B, DCP1B, DDB2, F11R, GADD45A, GSS, PLK3, TNFRSF10B, and XPC were identified. Of these genes, BAX, GSS, and TNFRSF10B are positively associated with both dose and time course, have a persistent transcriptional response, and might be better biological dosimeters. With the proposed approach, we may identify candidate biomarkers that change monotonically in relation to dose, have a persistent transcriptional response, and are reliable over a wide dose range.
DOI: 10.6084/m9.figshare.23902302.v1
title: Candidate biomarkers and persistent transcriptional responses after low and high dose ionizing radiation at high dose rate

description: Development of an integrated time and dose model to explore the dynamics of gene expression alterations and identify biomarkers for biodosimetry following low- and high-dose irradiations at high dose rate. We utilized multiple transcriptome datasets (GSE8917, GSE43151, and GSE23515) from Gene Expression Omnibus (GEO) for identifying candidate biological dosimeters. A linear mixed-effects model with random intercept was used to explore the dose-time dynamics of transcriptional responses and to functionally characterize the time- and dose-dependent changes in gene expression. We identified genes that are correlated with dose and time and discovered two clusters of genes that are either positively or negatively correlated with both dose and time based on the parameters of the model. Genes in these two clusters may have persistent transcriptional alterations. Twelve potential transcriptional markers for dosimetry—ARHGEF3, BAX, BBC3, CCDC109B, DCP1B, DDB2, F11R, GADD45A, GSS, PLK3, TNFRSF10B, and XPC were identified. Of these genes, BAX, GSS, and TNFRSF10B are positively associated with both dose and time course, have a persistent transcriptional response, and might be better biological dosimeters. With the proposed approach, we may identify candidate biomarkers that change monotonically in relation to dose, have a persistent transcriptional response, and are reliable over a wide dose range.
DOI: 10.6084/m9.figshare.23609129.v2
title: The effects of PKI-402 on breast tumor models’ radiosensitivity via dual inhibition of PI3K/mTOR

description: PI3K/Akt/mTOR pathway activation causes relapse and resistance after radiotherapy in breast cancer (BC). We aimed to radiosensitize BC cell lines to irradiation (IR) by PKI-402, a dual PI3K/mTOR inhibitor. We performed cytotoxicity, clonogenicity, hanging drop, apoptosis and double-strand break detection, and phosphorylation of 16 essential proteins involved in the PI3K/mTOR pathway. Our findings showed that PKI-402 has cytotoxic efficiency in all cell lines. Clonogenic assay results showed that PKI-402 plus IR inhibited the colony formation ability of MCF-7 and breast cancer stem cell lines. Results showed that PKI-402 plus IR causes more apoptotic cell death than IR alone in the MCF-7 cells but did not cause significant changes in the MDA-MB-231. γ-H2AX levels were increased in MDA-MB-231 in PKI-402 plus IR groups, whereas we did not observe any apoptotic and γ-H2AX induction in BCSCs and MCF-10A cells in all treatment groups. Some pivotal phosphorylated proteins of the PI3K/AKT pathway decreased, several proteins increased and others did not change. In conclusion, if the combined use of PKI-402 with radiation is supported by in vivo studies, it can contribute to the treatment options and the course of the disease.
DOI: 10.7295/w9cil54907
title: CIL:54907, Homo sapiens, pyramidal cell, neuron of cerebral cortex
DOI: 10.7295/w9cil54908
title: CIL:54908, Homo sapiens, pyramidal cell, neuron of cerebral cortex
DOI: 10.7295/w9cil54910
title: CIL:54910, Homo sapiens, pyramidal cell, neuron of cerebral cortex
DOI: 10.7295/w9cil54914
title: CIL:54914, Homo sapiens, pyramidal cell, neuron of cerebral cortex
DOI: 10.7295/w9cil54893
title: CIL:54893, Homo sapiens, pyramidal cell, neuron of cerebral cortex
DOI: 10.7295/w9cil54898
title: CIL:54898, Homo sapiens, pyramidal cell, neuron of cerebral cortex
DOI: 10.7295/w9cil54899
title: CIL:54899, Homo sapiens, pyramidal cell, neuron of cerebral cortex
DOI: 10.7295/w9cil54909
title: CIL:54909, Homo sapiens, pyramidal cell, neuron of cerebral cortex
DOI: 10.7295/w9cil54911
title: CIL:54911, Homo sapiens, pyramidal cell, neuron of cerebral cortex
DOI: 10.6084/m9.figshare.24596463
title: Supplementary Data S4: - Proteins over 10k lacking 'X' residues from BV-BRC database ('bvbrc_biggest_proteins_noX_labeled_sorted.faa')- Information on genomes from which these features were obtained ('BVBRC_genome_feature.csv')-Taxonomic information on these genomes ('big_proteins_taxonomy.tsv')

description: Supplementary data with information on bacterial proteins over 10,000 amino acids obtained from the BV-BRC database as discussed in the section '<b>Comparison with giant bacterial proteins outside the phylum </b><b><i>Omnitrophota'</i></b><i>.</i>
DOI: 10.6084/m9.figshare.24596463.v1
title: Supplementary Data S4: - Proteins over 10k lacking 'X' residues from BV-BRC database ('bvbrc_biggest_proteins_noX_labeled_sorted.faa')- Information on genomes from which these features were obtained ('BVBRC_genome_feature.csv')-Taxonomic information on these genomes ('big_proteins_taxonomy.tsv')

description: Supplementary data with information on bacterial proteins over 10,000 amino acids obtained from the BV-BRC database as discussed in the section '<b>Comparison with giant bacterial proteins outside the phylum </b><b><i>Omnitrophota'</i></b><i>.</i>
DOI: 10.7295/w9cil54897
title: CIL:54897, Homo sapiens, pyramidal cell, neuron of cerebral cortex
DOI: 10.7295/w9cil54901
title: CIL:54901, Homo sapiens, pyramidal cell, neuron of cerebral cortex
DOI: 10.34740/kaggle/dsv/7014141
title: BBC News
DOI: 10.6084/m9.figshare.24596490
title: Supplementary Data S7: All identified 30,000+ amino acid proteins from Omnitrophota

description: All identified 30k+ proteins from Omnitrophota genomes analyzed in this manuscript.
DOI: 10.34740/kaggle/dsv/7014153
title: Youtube Trending Video - Taiwan & Hong Kong
DOI: 10.25952/4wzf-g624
title: Management of Gut Health via in Situ Production of Bioactive Compounds in Broiler Chickens

description: The dataset consists of several .xlsx files. Firstly, the flow of undigested nutrients and non-starch polysaccharides remaining undigested in the gastrointestinal tract of broilers was measured (files: Paper 1 and Paper 2 raw data). An in vitro efficacy of nine different feed enzymes was evaluated using the digesta samples collected from Experiment 1 (file: Paper 4 raw data). The growth performance, nutrient digestibility, digesta viscosity and numerous gut health indicators were investigated in broilers offered the wheat- or maize-based diet supplemented with or without exogenous feed enzymes, in the presence or absence of necrotic enteritis (file: Paper 5 and 6 raw data). Throughout the study, digesta samples were collected from the digestive tract and analysed for non-starch polysaccharides using Gas Chromatography.
description: The dataset consists of several .xlsx files. Firstly, the flow of undigested nutrients and non-starch polysaccharides remaining undigested in the gastrointestinal tract of broilers was measured (files: Paper 1 and Paper 2 raw data). An in vitro efficacy of nine different feed enzymes was evaluated using the digesta samples collected from Experiment 1 (file: Paper 4 raw data). The growth performance, nutrient digestibility, digesta viscosity and numerous gut health indicators were investigated in broilers offered the wheat- or maize-based diet supplemented with or without exogenous feed enzymes, in the presence or absence of necrotic enteritis (file: Paper 5 and 6 raw data). Throughout the study, digesta samples were collected from the digestive tract and analysed for non-starch polysaccharides using Gas Chromatography.
DOI: 10.6084/m9.figshare.21590832.v1
title: Ethnographic Review of Hunting Sticks

description: A literature review was conducted in June 2021 using the search terms ‘hunting stick’ OR ‘throwing stick’, without limitation on subsistence type, using the eHRAF World Cultures database. I excluded examples that only pertained to games or toys, where use was only associated with ritual purposes, or where their use was as part of lore or oral traditions, unless it was noted from other sources that these societies had used such tools for hunting and/or violence. Additional sources from our own library and bibliographies were also included. Suitable excerpts were coded for location, use, prey type, and morphometrics. The dataset accompanies a submitted manuscript on an archaeological throwing stick titled <em>"Making and breaking Pleistocene wooden weapons. A chaîne opératoire analysis of a double-pointed stick from Schöningen, Germany" </em>authored by Annemieke Milks, Jens Lehmann, Michael Sietz, Tim Koddenberg, Utz Böhner<strong>, </strong>Dirk Leder<strong>,</strong> and Thomas Terberger.
DOI: 10.6084/m9.figshare.21590832
title: Ethnographic Review of Hunting Sticks

description: A literature review was conducted in June 2021 using the search terms ‘hunting stick’ OR ‘throwing stick’, without limitation on subsistence type, using the eHRAF World Cultures database. I excluded examples that only pertained to games or toys, where use was only associated with ritual purposes, or where their use was as part of lore or oral traditions, unless it was noted from other sources that these societies had used such tools for hunting and/or violence. Additional sources from our own library and bibliographies were also included. Suitable excerpts were coded for location, use, prey type, and morphometrics. The dataset accompanies a submitted manuscript on an archaeological throwing stick titled <em>"Making and breaking Pleistocene wooden weapons. A chaîne opératoire analysis of a double-pointed stick from Schöningen, Germany" </em>authored by Annemieke Milks, Jens Lehmann, Michael Sietz, Tim Koddenberg, Utz Böhner<strong>, </strong>Dirk Leder<strong>,</strong> and Thomas Terberger.
DOI: 10.5281/zenodo.10162494
title: Liste des ressources sélectionnées
DOI: 10.5281/zenodo.10162495
title: Liste des ressources sélectionnées
DOI: 10.5281/zenodo.10162441
title: Statistiques RS Swissintell
DOI: 10.5281/zenodo.10162442
title: Statistiques RS Swissintell
DOI: 10.26179/zhg8-cb10
title: Vestfold Hills Field Survey Report 2012-2013
DOI: 10.25345/c57h1dx9n
title: MassIVE MSV000093443 - 20210223_new_timedependent_human_fbmn_data
title: In vitro metabolite data of sildenafil using LC-QTOF/MS and human liver microsome at 2021. because of new policy of storage.
DOI: 10.5517/ccdc.csd.cc2ghx85
title: CCDC 2279407: Experimental Crystal Structure Determination

description: Related Article: Zhi-Mao Zhang, Junliang Zhang, Quan Cai|2023|Chemical Science|14|12598|doi:10.1039/D3SC04335E
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2gkl9y
title: CCDC 2281020: Experimental Crystal Structure Determination

description: Related Article: Tomasz Sokolnicki, Mashael M. Alharbi, Yara van Ingen, Shahnaz Rahim, Milan Pramanik, Alberto Roldan, Jędrzej Walkowiak, Rebecca L. Melen|2023|Dalton Trans.|52|16118|doi:10.1039/D3DT03333C
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2gklbz
title: CCDC 2281021: Experimental Crystal Structure Determination

description: Related Article: Tomasz Sokolnicki, Mashael M. Alharbi, Yara van Ingen, Shahnaz Rahim, Milan Pramanik, Alberto Roldan, Jędrzej Walkowiak, Rebecca L. Melen|2023|Dalton Trans.|52|16118|doi:10.1039/D3DT03333C
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2glv86
title: CCDC 2282228: Experimental Crystal Structure Determination

description: Related Article: Mouli Das Dawn, Karabi Nath, Subhajit Saha, Pritam Kumar Roy, Mahitosh Mandal, Kumar Biradha|2023|Mat.Advs.|4|5730|doi:10.1039/D3MA00681F
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2glv97
title: CCDC 2282229: Experimental Crystal Structure Determination

description: Related Article: Mouli Das Dawn, Karabi Nath, Subhajit Saha, Pritam Kumar Roy, Mahitosh Mandal, Kumar Biradha|2023|Mat.Advs.|4|5730|doi:10.1039/D3MA00681F
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2glvb8
title: CCDC 2282230: Experimental Crystal Structure Determination

description: Related Article: Mouli Das Dawn, Karabi Nath, Subhajit Saha, Pritam Kumar Roy, Mahitosh Mandal, Kumar Biradha|2023|Mat.Advs.|4|5730|doi:10.1039/D3MA00681F
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2gmfcx
title: CCDC 2282789: Experimental Crystal Structure Determination

description: Related Article: Eisuke Yasuo, Kohsuke Aikawa, Kyoko Nozaki, Takashi Okazoe|2023|Chemical Science|14|12379|doi:10.1039/D3SC04837C
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2gmnlc
title: CCDC 2283013: Experimental Crystal Structure Determination

description: Related Article: Zhijie Xu, Shuo Meng, Tong Cao, Yu Xin, Chunyan Wang, Hongguo Hao, Lu Yang, Zhen Zhou, Daopeng Zhang|2024|J.Mol.Struct.|1296|136866|doi:10.1016/j.molstruc.2023.136866
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2gmnmd
title: CCDC 2283014: Experimental Crystal Structure Determination

description: Related Article: Zhijie Xu, Shuo Meng, Tong Cao, Yu Xin, Chunyan Wang, Hongguo Hao, Lu Yang, Zhen Zhou, Daopeng Zhang|2024|J.Mol.Struct.|1296|136866|doi:10.1016/j.molstruc.2023.136866
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2gmnnf
title: CCDC 2283015: Experimental Crystal Structure Determination

description: Related Article: Zhijie Xu, Shuo Meng, Tong Cao, Yu Xin, Chunyan Wang, Hongguo Hao, Lu Yang, Zhen Zhou, Daopeng Zhang|2024|J.Mol.Struct.|1296|136866|doi:10.1016/j.molstruc.2023.136866
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2gmnpg
title: CCDC 2283016: Experimental Crystal Structure Determination

description: Related Article: Zhijie Xu, Shuo Meng, Tong Cao, Yu Xin, Chunyan Wang, Hongguo Hao, Lu Yang, Zhen Zhou, Daopeng Zhang|2024|J.Mol.Struct.|1296|136866|doi:10.1016/j.molstruc.2023.136866
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2gmnqh
title: CCDC 2283017: Experimental Crystal Structure Determination

description: Related Article: Zhijie Xu, Shuo Meng, Tong Cao, Yu Xin, Chunyan Wang, Hongguo Hao, Lu Yang, Zhen Zhou, Daopeng Zhang|2024|J.Mol.Struct.|1296|136866|doi:10.1016/j.molstruc.2023.136866
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.