cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.8273765.v1
title: Biotin attenuation of oxidative stress, mitochondrial dysfunction, lipid metabolism alteration and 7β-hydroxycholesterol-induced cell death in 158N murine oligodendrocytes

description: Mitochondrial dysfunction and oxidative stress are involved in neurodegenerative diseases associated with an enhancement of lipid peroxidation products such as 7β-hydroxycholesterol (7β-OHC). It is, therefore, important to study the ability of 7β-OHC to trigger mitochondrial defects, oxidative stress, metabolic dysfunctions and cell death, which are hallmarks of neurodegeneration, and to identify cytoprotective molecules. The effects of biotin were evaluated on 158N murine oligodendrocytes, which are myelin synthesizing cells, exposed to 7β-OHC (50 µM) with or without biotin (10 and 100 nM) or α-tocopherol (positive control of cytoprotection). The effects of biotin on 7β-OHC activities were determined using different criteria: cell adhesion; plasma membrane integrity; redox status. The impact on mitochondria was characterized by the measurement of transmembrane mitochondrial potential (ΔΨm), reactive oxygen species (ROS) overproduction, mitochondrial mass, quantification of cardiolipins and organic acids. Sterols and fatty acids were also quantified. Cell death (apoptosis, autophagy) was characterized by the enumeration of apoptotic cells, caspase-3 activation, identification of autophagic vesicles, and activation of LC3-I into LC3-II. Biotin attenuates 7β-OHC-induced cytotoxicity: loss of cell adhesion was reduced; antioxidant activities were normalized. ROS overproduction, protein and lipid oxidation products were decreased. Biotin partially restores mitochondrial functions: attenuation of the loss of ΔΨm; reduced levels of mitochondrial O<sub>2</sub><sup>•−</sup> overproduction; normalization of cardiolipins and organic acid levels. Biotin also normalizes cholesterol and fatty acid synthesis, and prevents apoptosis and autophagy (oxiapoptophagy). Our data support that biotin, which prevents oligodendrocytes damages, could be useful in the treatment of neurodegeneration and demyelination.
DOI: 10.6084/m9.figshare.8273816.v1
title: A soil phosphorus dynamics (SPD) model

description: The dynamics of soil phosphorus (P) control its bioavailability. Yet, it remains a challenge to quantify soil P dynamics. Here, we developed a soil P dynamics (SPD) model. We then assimilated eight datasets of 426-day changes in Hedley P fractions into the SPD model, to quantify the dynamics of six major P pools in eight soil samples that are representative of a wide type of soils. The performance of our SPD model was better for labile P, secondary mineral P, and occluded P than for non-occluded organic P (Po) and primary mineral P. All parameters describing soil P dynamics were approximately constrained by the datasets. The average turnover rates were labile P 0.040 g g<sup>-1</sup> d<sup>-1</sup>, non-occluded Po 0.051 g g<sup>-1</sup> d<sup>-1</sup>, secondary mineral P 0.023 g g<sup>-1</sup> d<sup>-1</sup>, primary mineral P 0.00088 g g<sup>-1</sup> d<sup>-1</sup>, occluded Po 0.0066 g g<sup>-1</sup> d<sup>-1</sup>, and occluded inorganic P 0.0065 g g<sup>-1</sup> d<sup>-1</sup>, in the greenhouse environment studied. Labile P was transferred on average more to non-occluded Po (transfer coefficient of 0.42) and secondary mineral P (0.38) than to plants (0.20). Soil pH and organic C concentration were the key soil properties regulating the competition for P between plants and soil secondary minerals. We also determined how soil P turnover rates and transfer coefficients were related and which of these parameters were important for simulating and forecasting the amount of soil labile P. Overall, we suggest data assimilation can contribute significantly to an improved understanding of the dynamics of soil P.
DOI: 10.6084/m9.figshare.8273774.v1
title: Individuals have unique muscle activation signatures as revealed during gait and pedalling

description: Raw electromyographic (EMG) data collected during walking on a treadmill (1.11 m/s) and pedalling on a cycloergometer (four different submaximal intensities: 10% and 15% of maximal power output; 80 and 150 Watts).Data are available for 80 participants (day 1). Reproducibility data (day 2) are available for 53 of these 80 participants.<br>
DOI: 10.6084/m9.figshare.8273756
title: SLAF.rar

description: <br>raw data of SLAF for<i><i> Anabasis aphylla</i></i>
DOI: 10.6084/m9.figshare.8273744
title: Dataset for: The Ventral Tegmental Area has calbindin neurons with the capability to co-release glutamate and dopamine into the nucleus accumbens

description: The ventral tegmental area (VTA) has three major classes of neurons: dopaminergic (expressing tyrosine hydroxylase; TH), GABAergic (expressing vesicular GABA transporter; VGaT) and glutamatergic (expressing vesicular glutamate transporter 2; VGluT2). While VTA dopaminergic and GABAergic neurons have been further characterized by expression of calcium-binding proteins (calbindin, CB; calretinin, CR or parvalbumin, PV), it is unclear whether these proteins are expressed in rat VTA glutamatergic neurons. Here, by a combination of in situ hybridization (for VGluT2 mRNA detection) and immunohistochemistry (for CB-, CR- or PV-detection), we found that among the total population of VGluT2 neurons, 30% coexpressed CB, 3% coexpressed PV and less than 1% coexpressed CR. Given that some VGluT2 neurons coexpress TH or VGaT, we examined whether these neurons coexpress CB, and found that about 20% of VGluT2-CB neurons coexpressed TH and about 13% coexpressed VGaT. Because VTA TH-CB neurons are known to target the nucleus accumbens (nAcc), we determined whether VGluT2-CB-TH neurons innervate nAcc, and found that about 80% of VGluT2-CB neurons innervating the nAcc shell coexpressed TH. In summary (a) CB, PV and CR are detected in subpopulations of VTA-VGluT2 neurons; (b) CB is the main calcium-binding protein present in VTA-VGluT2 neurons; (c) one-third of VTA-VGluT2 neurons coexpresses CB; (d) some VTA-VGluT2-CB neurons have the capability to co-release dopamine or GABA, and (e) a subpopulation of VTA-glutamatergic-dopaminergic neurons innervates nAcc shell. These findings further provide evidence for molecular diversity among VTA-VGluT2 neurons, neurons that may play a role in specific circuitry and behaviors.
DOI: 10.6084/m9.figshare.8273774.v2
title: Individuals have unique muscle activation signatures as revealed during gait and pedalling

description: Raw electromyographic (EMG) data collected during walking on a treadmill (1.11 m/s) and pedalling on a cycloergometer (four different submaximal intensities: 10% and 15% of maximal power output; 80 and 150 Watts).Data are available for 80 participants (day 1). Reproducibility data (day 2) are available for 53 of these 80 participants.<br>
DOI: 10.6084/m9.figshare.8273816.v2
title: A soil phosphorus dynamics (SPD) model

description: The dynamics of soil phosphorus (P) control its bioavailability. Yet, it remains a challenge to quantify soil P dynamics. Here, we developed a soil P dynamics (SPD) model. We then assimilated eight datasets of 426-day changes in Hedley P fractions into the SPD model, to quantify the dynamics of six major P pools in eight soil samples that are representative of a wide type of soils. The performance of our SPD model was better for labile P, secondary mineral P, and occluded P than for non-occluded organic P (Po) and primary mineral P. All parameters describing soil P dynamics were approximately constrained by the datasets. The average turnover rates were labile P 0.040 g g<sup>-1</sup> d<sup>-1</sup>, non-occluded Po 0.051 g g<sup>-1</sup> d<sup>-1</sup>, secondary mineral P 0.023 g g<sup>-1</sup> d<sup>-1</sup>, primary mineral P 0.00088 g g<sup>-1</sup> d<sup>-1</sup>, occluded Po 0.0066 g g<sup>-1</sup> d<sup>-1</sup>, and occluded inorganic P 0.0065 g g<sup>-1</sup> d<sup>-1</sup>, in the greenhouse environment studied. Labile P was transferred on average more to non-occluded Po (transfer coefficient of 0.42) and secondary mineral P (0.38) than to plants (0.20). Soil pH and organic C concentration were the key soil properties regulating the competition for P between plants and soil secondary minerals. The turnover rate of labile P was positively correlated with that of non-occluded Po and secondary mineral P. The pool size of labile P was most sensitive to its turnover rate. Overall, we suggest data assimilation can contribute significantly to an improved understanding of soil P dynamics.
DOI: 10.6084/m9.figshare.8273744.v1
title: Dataset for: The Ventral Tegmental Area has calbindin neurons with the capability to co-release glutamate and dopamine into the nucleus accumbens

description: The ventral tegmental area (VTA) has three major classes of neurons: dopaminergic (expressing tyrosine hydroxylase; TH), GABAergic (expressing vesicular GABA transporter; VGaT) and glutamatergic (expressing vesicular glutamate transporter 2; VGluT2). While VTA dopaminergic and GABAergic neurons have been further characterized by expression of calcium-binding proteins (calbindin, CB; calretinin, CR or parvalbumin, PV), it is unclear whether these proteins are expressed in rat VTA glutamatergic neurons. Here, by a combination of in situ hybridization (for VGluT2 mRNA detection) and immunohistochemistry (for CB-, CR- or PV-detection), we found that among the total population of VGluT2 neurons, 30% coexpressed CB, 3% coexpressed PV and less than 1% coexpressed CR. Given that some VGluT2 neurons coexpress TH or VGaT, we examined whether these neurons coexpress CB, and found that about 20% of VGluT2-CB neurons coexpressed TH and about 13% coexpressed VGaT. Because VTA TH-CB neurons are known to target the nucleus accumbens (nAcc), we determined whether VGluT2-CB-TH neurons innervate nAcc, and found that about 80% of VGluT2-CB neurons innervating the nAcc shell coexpressed TH. In summary (a) CB, PV and CR are detected in subpopulations of VTA-VGluT2 neurons; (b) CB is the main calcium-binding protein present in VTA-VGluT2 neurons; (c) one-third of VTA-VGluT2 neurons coexpresses CB; (d) some VTA-VGluT2-CB neurons have the capability to co-release dopamine or GABA, and (e) a subpopulation of VTA-glutamatergic-dopaminergic neurons innervates nAcc shell. These findings further provide evidence for molecular diversity among VTA-VGluT2 neurons, neurons that may play a role in specific circuitry and behaviors.
DOI: 10.6084/m9.figshare.8273729
title: Data Citation3 old

description: Data Citation3 including information of The qRT-PCR validation data.<br>
DOI: 10.6084/m9.figshare.8273726
title: Dataset 1

description: The FPKM values for <i>M. oryzae</i> and <i>O. sativa</i> transcriptome from all time points
DOI: 10.6084/m9.figshare.8273816.v3
title: A soil phosphorus dynamics (SPD) model

description: The dynamics of soil phosphorus (P) control its bioavailability. Yet, it remains a challenge to quantify soil P dynamics. Here, we developed a soil P dynamics (SPD) model. We then assimilated eight datasets of 426-day changes in Hedley P fractions into the SPD model, to quantify the dynamics of six major P pools in eight soil samples that are representative of a wide type of soils. The performance of our SPD model was better for labile P, secondary mineral P, and occluded P than for non-occluded organic P (Po) and primary mineral P. All parameters describing soil P dynamics were approximately constrained by the datasets. The average turnover rates were labile P 0.040 g g<sup>-1</sup> d<sup>-1</sup>, non-occluded Po 0.051 g g<sup>-1</sup> d<sup>-1</sup>, secondary mineral P 0.023 g g<sup>-1</sup> d<sup>-1</sup>, primary mineral P 0.00088 g g<sup>-1</sup> d<sup>-1</sup>, occluded Po 0.0066 g g<sup>-1</sup> d<sup>-1</sup>, and occluded inorganic P 0.0065 g g<sup>-1</sup> d<sup>-1</sup>, in the greenhouse environment studied. Labile P was transferred on average more to non-occluded Po (transfer coefficient of 0.42) and secondary mineral P (0.38) than to plants (0.20). Soil pH and organic C concentration were the key soil properties regulating the competition for P between plants and soil secondary minerals. The turnover rate of labile P was positively correlated with that of non-occluded Po and secondary mineral P. The pool size of labile P was most sensitive to its turnover rate. Overall, we suggest data assimilation can contribute significantly to an improved understanding of soil P dynamics.
DOI: 10.6084/m9.figshare.8273720
title: CCK Feeding Study

description: Male mice fed with 5 weeks of LF/HF diet.
DOI: 10.6084/m9.figshare.8273714
title: Weekly body weight & food intake

description: Male and female mice fed with 5 weeks of LF/HF diet.
DOI: 10.6084/m9.figshare.8273720.v1
title: CCK Feeding Study

description: Male mice fed with 5 weeks of LF/HF diet.
DOI: 10.6084/m9.figshare.8273711
title: Fat Pad Mass

description: Male and female mice fed with 5 weeks of LF/HF diet.
DOI: 10.6084/m9.figshare.8273726.v1
title: Data Citation2

description: Data Citation2 including information of The detailed transcriptome information and the FPKM values of each gene for <i>M. oryzae</i> and <i>O. sativa</i> from all time points
DOI: 10.6084/m9.figshare.8273708
title: DEXA

description: Male and female mice fed with 5 weeks of LF/HF diet.
DOI: 10.6084/m9.figshare.8273711.v1
title: Fat Pad Mass

description: Male and female mice fed with 5 weeks of LF/HF diet.
DOI: 10.6084/m9.figshare.8273708.v1
title: DEXA

description: Male and female mice fed with 5 weeks of LF/HF diet.
DOI: 10.6084/m9.figshare.8273717.v1
title: Data Citation1

description: Data Citation1 including information of The raw reads of transcriptome data were deposited in NCBI Sequence Read Archive (SRA)
DOI: 10.6084/m9.figshare.8273726.v2
title: Dataset 1

description: The detailed transcriptome information and the FPKM values of each gene for <i>M. oryzae</i> and <i>O. sativa</i> from all time points
DOI: 10.6084/m9.figshare.8273696
title: Meal Pattern

description: Male and female mice fed with 5 weeks of LF/HF diet.
DOI: 10.6084/m9.figshare.8273717.v2
title: Data Citation

description: Data Citation1 including information of The raw reads of transcriptome data were deposited in NCBI Sequence Read Archive (SRA)
DOI: 10.6084/m9.figshare.8273687
title: CLAMS

description: Data for energy expenditure and respiratory exchange ratio
DOI: 10.6084/m9.figshare.8273693
title: Activity

description: Male and female mice fed with 5 weeks of LF/HF diet.
DOI: 10.6084/m9.figshare.8273696.v1
title: Meal Pattern

description: Male and female mice fed with 5 weeks of LF/HF diet.
DOI: 10.6084/m9.figshare.8273717.v3
title: Data Citation1

description: Data Citation1 including information of The raw reads of transcriptome data were deposited in NCBI Sequence Read Archive (SRA)
DOI: 10.6084/m9.figshare.8273165
title: data_paper_seas_mean_IndoSeas

description: Matlab variables obtained from the numerical simulations. The grid variables correspond to the MITgcm grid variables.<br>
DOI: 10.6084/m9.figshare.8273102
title: Processed files (to use with scanpy)

description: h5ad files to use with scanpy<br>*8/8/2019*Marrow_droplet.h5ad updated<br>*7/15/2020*For individual tissue objects please use the updated objects in:https://figshare.com/articles/dataset/Tabula_Muris_Senis_Data_Objects/12654728<br><br>*7/18/2020*<br>Complete dataset uploaded with updated objects
DOI: 10.6084/m9.figshare.8273006
title: Dataset-2019.xlsx

description: A dataset that is useful for training in applied biostatistics, in the context of biomedical research
DOI: 10.6084/m9.figshare.8269931
title: Authentication of 5-bromo-3-chloro-1,2-dimethoxybenzene

description: Authentication of 5-bromo-3-chloro-1,2-dimethoxybenzene by NMR and GC-MS. This compound was synthesized from 4-bromo-2-chloro-6-fluoroanisole via aromatic nucleophilic substitution in the presence of sodium methoxide and is a precursor for the preparation of 3,3'-dichloro-4,5-dimethoxy-biphenyl, a derivative of PCB 11 (3,3'-dichlorobiphenyl).
DOI: 10.6084/m9.figshare.8269823
title: Traffic bridges

description: Density and flow of ants on several bridges during foraging.
DOI: 10.6084/m9.figshare.8269832
title: Authentication of 3,3'-dichloro-4,5-dimethoxy-biphenyl

description: 3,3'-Dichloro-4,5-dimethoxy-biphenyl is a derivative of PCB 11 (3,3'-dichlorobiphenyl) and was synthesized as an analytical standard to study the metabolism of PCB 11, a polychlorinated biphenyl (PCB) congener that is not present in technical PCB mixtures. This compound was synthesized via Suzuki cross coupling of 5-bromo-3-chloro-1,2-dimethoybenzene and 3-chlorophenylboronic acid.<br>
DOI: 10.6084/m9.figshare.8269790
title: Access to Healthy Assets and Hazards - open data for measuring health-related neighbourhood features

description: @page { margin: 2cm } p { margin-bottom: 0.25cm; line-height: 120% } a:link { so-language: zxx } AHAH (the index of ‘Access to Health Assets and Hazards’) is a composite index developed by the CDRC for Great Britain measuring how ‘healthy’ neighbourhoods are. It is based on: accessibility to retail outlets (fast food outlets, pubs, off-licences, tobacconists, gambling outlets), accessibility to health services (GPs, hospitals, pharmacies, dentists, leisure services), and the quality of the physical environment (green space, air pollution). AHAH is produced for Lower Super Output Areas for England and Wales, and Data Zones for Scotland.
DOI: 10.6084/m9.figshare.8269784
title: Excavation of the Later Stone Age Site of Madola - Kiwangwa, Bagamoyo, Tanzania

description: Reports on the Later Stone Age (LSA) assemblages along the coast of mainland Tanzania and the surrounding islands date back to the 1960s. However, most of these involved sketchy descriptions of lithic materials from varied contexts, including excavations and surface collections. Most were also by-products of accidental discoveries during other research endeavours, since no one had focused their research on the Tanzanian coastal Stone Age. Excavation of the Madola LSA site in Kiwangwa Village was aimed at addressing this problem, as well as building up a database for the Tanzanian coastal LSA industry. Unlike most areas of the Tanzanian coast where lithic artefacts occur in light scatters, the Madola site consists of a richer artefact assemblage that is comparable to those of inland sites, despite variation in artefact types and quantities. The Madola LSA assemblage predates 14,404 ± 86 BP, with quartz as the predominant raw material and bipolar flaking the main method used to produce artefacts. The site was later occupied by Plain Ware makers, after which it was abandoned until modern times.
DOI: 10.6084/m9.figshare.8269790.v1
title: Access to Healthy Assets and Hazards - open data for measuring health-related neighbourhood features

description: @page { margin: 2cm } p { margin-bottom: 0.25cm; line-height: 120% } a:link { so-language: zxx } AHAH (the index of ‘Access to Health Assets and Hazards’) is a composite index developed by the CDRC for Great Britain measuring how ‘healthy’ neighbourhoods are. It is based on: accessibility to retail outlets (fast food outlets, pubs, off-licences, tobacconists, gambling outlets), accessibility to health services (GPs, hospitals, pharmacies, dentists, leisure services), and the quality of the physical environment (green space, air pollution). AHAH is produced for Lower Super Output Areas for England and Wales, and Data Zones for Scotland.
DOI: 10.6084/m9.figshare.8269823.v2
title: Traffic bridges

description: Density and flow of ants on several bridges during foraging.
DOI: 10.6084/m9.figshare.8269763
title: Bad News Dataset

description: Dataset for Roozenbeek and van der Linden (2019) Fake news game confers psychological resistance against online misinformation. Palgrave Communications. <br><br>
DOI: 10.6084/m9.figshare.8269784.v1
title: Excavation of the Later Stone Age Site of Madola - Kiwangwa, Bagamoyo, Tanzania

description: Reports on the Later Stone Age (LSA) assemblages along the coast of mainland Tanzania and the surrounding islands date back to the 1960s. However, most of these involved sketchy descriptions of lithic materials from varied contexts, including excavations and surface collections. Most were also by-products of accidental discoveries during other research endeavours, since no one had focused their research on the Tanzanian coastal Stone Age. Excavation of the Madola LSA site in Kiwangwa Village was aimed at addressing this problem, as well as building up a database for the Tanzanian coastal LSA industry. Unlike most areas of the Tanzanian coast where lithic artefacts occur in light scatters, the Madola site consists of a richer artefact assemblage that is comparable to those of inland sites, despite variation in artefact types and quantities. The Madola LSA assemblage predates 14,404 ± 86 BP, with quartz as the predominant raw material and bipolar flaking the main method used to produce artefacts. The site was later occupied by Plain Ware makers, after which it was abandoned until modern times.
DOI: 10.6084/m9.figshare.8269823.v1
title: Traffic bridges

description: Density and flow of ants on several bridges during foraging.
DOI: 10.6084/m9.figshare.8269742
title: Detrital garnet chemistry from the Molasse basin

description: This is a dataset on major element concentrations of garnet from the Swiss part of the northern alpine foreland basin (Molasse basin). The dataset comprises detrital garnet analyses from 25My, 19My and 14My old sandstones from the Napf fan (Bern area, Switzerland) as well as some selected source rock data from the Central Alps.
DOI: 10.6084/m9.figshare.8269736
title: Cleaned Files

description: The results of running the cleandata() function on the raw files. Because the Carelink 670G report includes a limited amount of data, the cleaned file has been manually edited so that only dates 10/17/18 - 10/30/18 are included. <br><br>To compare the function cgmvariables() to the iPro 2 report, parameters aboveexcursionlength = 15 and belowexcursionlength = 15 must be used. <br><br>
DOI: 10.6084/m9.figshare.8269721
title: Blue whale home range shapefiles from: Spatial and temporal occurrence of blue whales off the U.S. West Coast, with implications for management.

description: This data repository contains an Arc Package for Esri ArcGIS software with shapefiles of home ranges estimated for 53 blue whales (Balaenoptera musculus) tracked with Argos satellite tags off the U.S. West Coast between 1994 and 2008. Home ranges were calculated with an LSCV kernel density estimator for tracks at least 30 d in duration as documented in Irvine et al 2014 (see reference link). The raw tracking data that was used to produce these home ranges are deposited as a Movebank Repository (Mate et al. 2019; see second reference link).<br>
DOI: 10.6084/m9.figshare.8269742.v1
title: Detrital garnet chemistry from the Molasse basin

description: This is a dataset on major element concentrations of garnet from the Swiss part of the northern alpine foreland basin (Molasse basin). The dataset comprises detrital garnet analyses from 25My, 19My and 14My old sandstones from the Napf fan (Bern area, Switzerland) as well as some selected source rock data from the Central Alps.
DOI: 10.6084/m9.figshare.8269691
title: Raw Files

description: These data are the files used to compare the cgmanalysis R package to proprietary CGM metrics. When running the cleandata() function on these files, set removegaps = F.<br>
DOI: 10.6084/m9.figshare.8269703
title: Hominin Recombination Maps

description: Recombination Maps for extant and ancient Hominins generated using the program iSMC (see reference)<br>
DOI: 10.6084/m9.figshare.8269703.v2
title: Hominin Recombination Maps

description: Recombination Maps for extant and ancient Hominins generated using the program iSMC (see reference)<br>
DOI: 10.6084/m9.figshare.8269703.v1
title: Hominin Recombination Maps

description: Recombination Maps for extant and ancient Hominins generated using the program iSMC (see reference)<br>