cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.21076294.v1
title: A plant virus hijacks phosphatidylinositol-3,5-bisphosphate to escape autophagic degradation in its insect vector

description: Hosts can initiate macroautophagy/autophagy as an antiviral defense response, while viruses have developed multiple ways to evade the host autophagic degradation. However, little is known as to whether viruses can target lipids to subvert autophagic degradation. Here, we show that a low abundant signaling lipid, phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P<sub>2</sub>), is required for rice black-streaked dwarf virus (RBSDV) to evade the autophagic degradation in the insect vector <i>Laodelphax striatellus</i>. RBSDV binds to PtdIns(3,5)P<sub>2</sub> and elevates its level through its main capsid protein P10, leading to inhibited autophagy and promoted virus propagation. Furthermore, we show that PtdIns(3,5)P<sub>2</sub> inhibits the autophagy pathway by preventing the fusion of autophagosomes and lysosomes through activation of Trpml (transient receptor potential cation channel, mucolipin), an effector of PtdIns(3,5)P<sub>2</sub>. These findings uncover a strategy whereby a plant virus hijacks PtdIns(3,5)P<sub>2</sub> via its viral capsid protein to evade autophagic degradation and promote its survival in insects.
DOI: 10.6084/m9.figshare.21170766.v1
title: NLRC5 Restricts Dengue Virus Infection by Promoting the Autophagic Degradation of Viral NS3 through E3 Ligase CUL2 (cullin 2)

description: NLRC5 has been reported to be involved in antiviral immunity; however, the underlying mechanism remains poorly understood. Here, we investigated the functional role of NLRC5 in the infection of a flavivirus, dengue virus (DENV). We found that expression of NLRC5 was strongly induced by virus infection and IFNB or IFNG stimulation in different cell lines. Overexpression of NLRC5 remarkably suppressed DENV infection, whereas knockout of <i>NLRC5</i> led to a significant increase in DENV infection. Mechanistic study revealed that NLRC5 interacted with the viral nonstructural protein 3 (NS3) protease domain and mediated degradation of NS3 through a ubiquitin-dependent selective macroautophagy/autophagy pathway. We demonstrated that NLRC5 recruited the E3 ubiquitin ligase CUL2 (cullin 2) to catalyze K48-linked poly-ubiquitination of the NS3 protease domain, which subsequently served as a recognition signal for cargo receptor TOLLIP-mediated selective autophagic degradation. Together, we have demonstrated that NLRC5 exerted an antiviral effect by mediating the degradation of a multifunctional protein of DENV, providing a novel antiviral signal axis of NLRC5-CUL2-NS3-TOLLIP. This study expands our understanding of the regulatory network of NLRC5 in the host defense against virus infection.
DOI: 10.6084/m9.figshare.21076294
title: A plant virus hijacks phosphatidylinositol-3,5-bisphosphate to escape autophagic degradation in its insect vector

description: Hosts can initiate macroautophagy/autophagy as an antiviral defense response, while viruses have developed multiple ways to evade the host autophagic degradation. However, little is known as to whether viruses can target lipids to subvert autophagic degradation. Here, we show that a low abundant signaling lipid, phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P<sub>2</sub>), is required for rice black-streaked dwarf virus (RBSDV) to evade the autophagic degradation in the insect vector <i>Laodelphax striatellus</i>. RBSDV binds to PtdIns(3,5)P<sub>2</sub> and elevates its level through its main capsid protein P10, leading to inhibited autophagy and promoted virus propagation. Furthermore, we show that PtdIns(3,5)P<sub>2</sub> inhibits the autophagy pathway by preventing the fusion of autophagosomes and lysosomes through activation of Trpml (transient receptor potential cation channel, mucolipin), an effector of PtdIns(3,5)P<sub>2</sub>. These findings uncover a strategy whereby a plant virus hijacks PtdIns(3,5)P<sub>2</sub> via its viral capsid protein to evade autophagic degradation and promote its survival in insects.
DOI: 10.5281/zenodo.14846822
title: REGENIE results of brain IDP GWAS (Part 4)

description: ❯ md5sum swi_median_20241122_wbr*3bd7a5baa72a5cd4297b5f16df819386  swi_median_20241122_wbr.zipe06490be9637b815c0d5ff55eae6caf9  swi_median_20241122_wbr_IDP_SWI_T2star_left_accumbens.regenie.gz7826826bde3b9891cc3a62a8f8c83c1f  swi_median_20241122_wbr_IDP_SWI_T2star_left_amygdala.regenie.gzd3617cb3d7952441caf1d8d271132ca3  swi_median_20241122_wbr_IDP_SWI_T2star_left_caudate.regenie.gz85a21a8585d938f73fce7c8a08c5ad23  swi_median_20241122_wbr_IDP_SWI_T2star_left_hippocampus.regenie.gz1b1702c23aba5bfceb075bb650c1aace  swi_median_20241122_wbr_IDP_SWI_T2star_left_pallidum.regenie.gz7090382718d7d5b02dc0199b5e3db10d  swi_median_20241122_wbr_IDP_SWI_T2star_left_putamen.regenie.gzcb27ba77eb787f8a7d886ce227a153f4  swi_median_20241122_wbr_IDP_SWI_T2star_left_thalamus.regenie.gzee61e4ad72b4e02a2a584b068793cbed  swi_median_20241122_wbr_IDP_SWI_T2star_right_accumbens.regenie.gz645fa3ea54f73e25b8b36cf765870848  swi_median_20241122_wbr_IDP_SWI_T2star_right_amygdala.regenie.gzab25596d0e53e5af1a2ff6f484aa13a4  swi_median_20241122_wbr_IDP_SWI_T2star_right_caudate.regenie.gz2a779debb9ad8c3b362147a7c869f8b8  swi_median_20241122_wbr_IDP_SWI_T2star_right_hippocampus.regenie.gzd0a07c063d832d59f7ef1f736b9b495b  swi_median_20241122_wbr_IDP_SWI_T2star_right_pallidum.regenie.gz049f3f3eafeea4313cc98706ce26b703  swi_median_20241122_wbr_IDP_SWI_T2star_right_putamen.regenie.gza64f5be7896fc3f094a4d565174d5e24  swi_median_20241122_wbr_IDP_SWI_T2star_right_thalamus.regenie.gz
DOI: 10.5281/zenodo.14846823
title: REGENIE results of brain IDP GWAS (Part 4)

description: ❯ md5sum swi_median_20241122_wbr*3bd7a5baa72a5cd4297b5f16df819386  swi_median_20241122_wbr.zipe06490be9637b815c0d5ff55eae6caf9  swi_median_20241122_wbr_IDP_SWI_T2star_left_accumbens.regenie.gz7826826bde3b9891cc3a62a8f8c83c1f  swi_median_20241122_wbr_IDP_SWI_T2star_left_amygdala.regenie.gzd3617cb3d7952441caf1d8d271132ca3  swi_median_20241122_wbr_IDP_SWI_T2star_left_caudate.regenie.gz85a21a8585d938f73fce7c8a08c5ad23  swi_median_20241122_wbr_IDP_SWI_T2star_left_hippocampus.regenie.gz1b1702c23aba5bfceb075bb650c1aace  swi_median_20241122_wbr_IDP_SWI_T2star_left_pallidum.regenie.gz7090382718d7d5b02dc0199b5e3db10d  swi_median_20241122_wbr_IDP_SWI_T2star_left_putamen.regenie.gzcb27ba77eb787f8a7d886ce227a153f4  swi_median_20241122_wbr_IDP_SWI_T2star_left_thalamus.regenie.gzee61e4ad72b4e02a2a584b068793cbed  swi_median_20241122_wbr_IDP_SWI_T2star_right_accumbens.regenie.gz645fa3ea54f73e25b8b36cf765870848  swi_median_20241122_wbr_IDP_SWI_T2star_right_amygdala.regenie.gzab25596d0e53e5af1a2ff6f484aa13a4  swi_median_20241122_wbr_IDP_SWI_T2star_right_caudate.regenie.gz2a779debb9ad8c3b362147a7c869f8b8  swi_median_20241122_wbr_IDP_SWI_T2star_right_hippocampus.regenie.gzd0a07c063d832d59f7ef1f736b9b495b  swi_median_20241122_wbr_IDP_SWI_T2star_right_pallidum.regenie.gz049f3f3eafeea4313cc98706ce26b703  swi_median_20241122_wbr_IDP_SWI_T2star_right_putamen.regenie.gza64f5be7896fc3f094a4d565174d5e24  swi_median_20241122_wbr_IDP_SWI_T2star_right_thalamus.regenie.gz
DOI: 10.15468/dl.2g6sqq
title: Occurrence Download

description: A dataset containing 125113 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Geometry POLYGON((-78.48641 -3.29708,-78.92985 -5.07084,-77.46457 -6.20837,-75.84505 -5.61069,-75.49801 -4.2418,-77.29105 -3.00788,-78.48641 -3.29708))",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "TaxonKey is Plantae"
 ]
}

 The dataset includes 125113 records from 177 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0023142-250127130748423/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.34740/kaggle/dsv/10712618
title: Covid: Brazilian Tweets
DOI: 10.5281/zenodo.14847407
title: "ELEKTRODINAMIKA" BO'LIMIGA OID MUAMMOLI MAZMUNDAGI MASALALAR YECHISH METODIKASI.
DOI: 10.5281/zenodo.14847408
title: "ELEKTRODINAMIKA" BO'LIMIGA OID MUAMMOLI MAZMUNDAGI MASALALAR YECHISH METODIKASI.
DOI: 10.34740/kaggle/dsv/10712438
title: Covid: Portuguese Tweets
DOI: 10.5281/zenodo.14847412
title: MULTI-POLAR WORLD: IMBALANCE OF FOREIGN POLICY OF THE US,    RUSSIA AND CHINA IN SOLVING REGIONAL CONFLICTS.
DOI: 10.5281/zenodo.14847413
title: MULTI-POLAR WORLD: IMBALANCE OF FOREIGN POLICY OF THE US,    RUSSIA AND CHINA IN SOLVING REGIONAL CONFLICTS.
DOI: 10.5281/zenodo.14847419
title: PHONOVARIATION IN CHINESE AND UZBEK LANGUAGES: FUNCTIONAL, SEMANTIC, AND STYLISTIC ASPECTS
DOI: 10.5281/zenodo.14847420
title: PHONOVARIATION IN CHINESE AND UZBEK LANGUAGES: FUNCTIONAL, SEMANTIC, AND STYLISTIC ASPECTS
DOI: 10.34740/kaggle/ds/6578592
title: 🎲 BoardGameGeek| Games + Reviews as of Feb 2025
DOI: 10.15468/dl.6e3u4g
title: Occurrence Download

description: A dataset containing 1095315 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is one of (Belgium, Germany, Netherlands)",
 "TaxonKey is one of (Ondatra zibethicus (Linnaeus, 1766), Myocastor coypus (Molina, 1782))",
 "OccurrenceStatus is Present"
 ]
}

 The dataset includes 1095315 records from 77 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0023135-250127130748423/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.jjmth2
title: Occurrence Download

description: A dataset containing 219742 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is Belgium",
 "TaxonKey is one of (Aponogeton distachyos L.f., Arthurdendyus triangulatus (Dendy, 1895), Cabomba caroliniana A.Gray, Callosciurus finlaysonii (Horsfield, 1823), Cherax destructor Clark, 1936, Corvus splendens Vieillot, 1817, Crassula helmsii (Kirk) Cockayne, Elodea densa (Planch.) Casp., Eriocheir sinensis H.Milne Edwards, 1853, Erythranthe guttata (DC.) G.L.Nesom, Faxonius immunis (Hagen, 1870), Faxonius juvenilis (Hagen, 1870), Faxonius rusticus (Girard, 1852), Faxonius virilis (Hagen, 1870), Gambusia affinis (Baird & Girard, 1853), Heracleum mantegazzianum Sommier & Levier, Heracleum persicum Desf. ex Fisch., C.A.Mey. & Avé-Lall., Heracleum pubescens (Hoffm.) M.Bieb., Houttuynia cordata Thunb., Hydrocotyle ranunculoides L.f., Impatiens glandulifera Royle, Koenigia polystachya (Wall. ex Meisn.) T.M.Schust. & Reveal, Lagarosiphon major (Ridl.) Moss, Lepomis gibbosus (Linnaeus, 1758), Limnoperna fortunei (Dunker, 1857), Ludwigia grandiflora (Michx.) Greuter & Burdet, Ludwigia peploides (Kunth) P.H.Raven, Lysichiton americanus Hultén & H.St.John, Morone americana (Gmelin, 1789), Muntiacus reevesi (Ogilby, 1839), Myriophyllum aquaticum (Vell.) Verdc., Myriophyllum heterophyllum Michx., Pacifastacus leniusculus (Dana, 1852), Petasites japonicus (Siebold & Zucc.) Maxim., Pontederia cordata L., Procambarus acutus (Girard, 1852), Procambarus clarkii (Girard, 1852), Procambarus virginalis Lyko, 2017, Pseudorasbora parva (Temminck & Schlegel, 1846), Pycnonotus cafer (Linnaeus, 1766), Saururus cernuus L., Sciurus carolinensis Gmelin, 1788, Sciurus niger Linnaeus, 1758, Solenopsis invicta Buren, 1972, Solenopsis richteri Forel, 1909, Threskiornis aethiopicus (Latham, 1790), Vespa velutina Lepeletier, 1836, Zizania latifolia (Griseb.) Hance ex F.Muell.)",
 "OccurrenceStatus is Present",
 "Year is greater than or equal to 2000"
 ]
}

 The dataset includes 219742 records from 82 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0023136-250127130748423/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.5281/zenodo.14847431
title: LIFE PARH AND ACADEMIC ACTIVITY OF ALI AL-QARI
DOI: 10.5281/zenodo.14847432
title: LIFE PARH AND ACADEMIC ACTIVITY OF ALI AL-QARI
DOI: 10.5281/zenodo.14847217
title: Daily Weather and Wildfire Ignition Dataset

description: The Daily Weather and Ignition Data Set contains meteorological and fire ignition data for the area spanning latitudes 48.5◦N to 60.0◦N and longitudes -139.1◦W to -114.0◦E. It covers the years from 1980 to 2020 at a temporal resolution of 1 day. The months from October thru March are excluded. It was produced as part of the paper  'A Framework for CreatingForest Fire Ignition Prediction Datasets'.
DOI: 10.5281/zenodo.14847218
title: Daily Weather and Wildfire Ignition Dataset

description: The Daily Weather and Ignition Data Set contains meteorological and fire ignition data for the area spanning latitudes 48.5◦N to 60.0◦N and longitudes -139.1◦W to -114.0◦E. It covers the years from 1980 to 2020 at a temporal resolution of 1 day. The months from October thru March are excluded. It was produced as part of the paper  'A Framework for CreatingForest Fire Ignition Prediction Datasets'.
DOI: 10.5281/zenodo.14847442
title: Natural history specimens collected and/or identified and deposited.

description: Natural history specimen data collected and/or identified by Ferdinando Augusto Artaria, http://www.wikidata.org/entity/Q21505363. Claims or attributions were made on Bionomia, https://bionomia.net using specimen data from the Global Biodiversity Information Facility, https://gbif.org.
description: http://www.wikidata.org/entity/Q21505363
DOI: 10.5281/zenodo.14847443
title: Natural history specimens collected and/or identified and deposited.

description: Natural history specimen data collected and/or identified by Ferdinando Augusto Artaria, http://www.wikidata.org/entity/Q21505363. Claims or attributions were made on Bionomia, https://bionomia.net using specimen data from the Global Biodiversity Information Facility, https://gbif.org.
description: http://www.wikidata.org/entity/Q21505363
DOI: 10.5281/zenodo.13985500
title: Sub-Neptune Radii Grids
DOI: 10.5281/zenodo.14835108
title: Sub-Neptune Radii Grids

description: This repository provides the latest sub-Neptune radii grids from Tang et al. 2025. 

We include 18 grids covering various pressure levels, ages, and atmospheric metallicities. The files follow the naming format {pressure}_{age}_{metallicity}.csv, where:



Pressure levels: 20 mbar, 1 nbar, RCB

Ages: 100 Myr, 1 Gyr, 10 Gyr

Metallicities: 1×, 50× (in units of solar metallicity)


Additionally, the boil-off_{metallicity}.csv grids provide the maximum H/He mass fraction allowed by a boil-off phase. Please refer to these grids to ensure that the chosen model parameters remain physically reasonable.

Each radius grid presents radii at the specified pressure level, age, and atmospheric metallicity, while varying the rock/iron core mass, H/He mass fraction, and incident bolometric flux. The grids can be read using:

pd.read_csv({pressure}_{age}_{metallicity}.csv, comment='#')

For an overview of all grids, see Sub_Neptune_Radius_Grids.pdf. For additional details, please refer to the paper. For additional radii data not included in this repository, please contact yaotang@ucsc.edu.
DOI: 10.5281/zenodo.14847418
title: Sub-Neptune Radii Grids

description: This repository provides the latest sub-Neptune radii grids from Tang et al. 2025. 

We include 24 grids covering various pressure levels, ages, and atmospheric metallicities. The files follow the naming format {pressure}_{age}_{metallicity}.csv, where:



Pressure levels: 20 mbar, 1 nbar, RCB

Ages: 10 Myr, 100 Myr, 1 Gyr, 10 Gyr

Metallicities: 1×, 50× (in units of solar metallicity)


Additionally, the boil-off_{metallicity}.csv grids provide the maximum H/He mass fraction allowed by a boil-off phase. Please refer to these grids to ensure that the chosen model parameters remain physically reasonable.

Each radius grid presents radii (in Earth radii) at the specified pressure level, age, and atmospheric metallicity, while varying the rock/iron core mass (1-20 Earth masses), H/He mass fraction (0.1-20%), and incident bolometric flux (1-1000 Earth fluxes). The grids can be read using:

pd.read_csv({pressure}_{age}_{metallicity}.csv, comment='#')

For an overview of all grids, see Sub_Neptune_Radius_Grids.pdf. For additional details, please refer to the paper. For additional radii data not included in this repository, please contact yaotang@ucsc.edu.
DOI: 10.5281/zenodo.13985499
title: Sub-Neptune Radii Grids

description: This repository provides the latest sub-Neptune radii grids from Tang et al. 2025. 

We include 24 grids covering various pressure levels, ages, and atmospheric metallicities. The files follow the naming format {pressure}_{age}_{metallicity}.csv, where:



Pressure levels: 20 mbar, 1 nbar, RCB

Ages: 10 Myr, 100 Myr, 1 Gyr, 10 Gyr

Metallicities: 1×, 50× (in units of solar metallicity)


Additionally, the boil-off_{metallicity}.csv grids provide the maximum H/He mass fraction allowed by a boil-off phase. Please refer to these grids to ensure that the chosen model parameters remain physically reasonable.

Each radius grid presents radii (in Earth radii) at the specified pressure level, age, and atmospheric metallicity, while varying the rock/iron core mass (1-20 Earth masses), H/He mass fraction (0.1-20%), and incident bolometric flux (1-1000 Earth fluxes). The grids can be read using:

pd.read_csv({pressure}_{age}_{metallicity}.csv, comment='#')

For an overview of all grids, see Sub_Neptune_Radius_Grids.pdf. For additional details, please refer to the paper. For additional radii data not included in this repository, please contact yaotang@ucsc.edu.
DOI: 10.5281/zenodo.14827970
title: Sub-Neptune Radii Grids

description: This repository provides the latest sub-Neptune radii grids from Tang et al. 2025. 

We include 18 grids covering various pressure levels, ages, and atmospheric metallicities. The files follow the naming format {pressure}_{age}_{metallicity}.csv, where:



Pressure levels: 20 mbar, 1 nbar, RCB

Ages: 100 Myr, 1 Gyr, 10 Gyr

Metallicities: 1×, 50× (in units of solar metallicity)


Additionally, the boil-off_{metallicity}.csv grids provide the maximum H/He mass fraction allowed by a boil-off phase. Please refer to these grids to ensure that the chosen model parameters remain physically reasonable.

Each radius grid presents radii at the specified pressure level, age, and atmospheric metallicity, while varying the rock/iron core mass, H/He mass fraction, and incident bolometric flux.

For an overview of all grids, see Sub_Neptune_Radius_Grids.pdf. For additional details, please refer to the paper. For additional radii data not included in this repository, please contact yaotang@ucsc.edu.
DOI: 10.5281/zenodo.14835120
title: Sub-Neptune Radii Grids

description: This repository provides the latest sub-Neptune radii grids from Tang et al. 2025. 

We include 18 grids covering various pressure levels, ages, and atmospheric metallicities. The files follow the naming format {pressure}_{age}_{metallicity}.csv, where:



Pressure levels: 20 mbar, 1 nbar, RCB

Ages: 100 Myr, 1 Gyr, 10 Gyr

Metallicities: 1×, 50× (in units of solar metallicity)


Additionally, the boil-off_{metallicity}.csv grids provide the maximum H/He mass fraction allowed by a boil-off phase. Please refer to these grids to ensure that the chosen model parameters remain physically reasonable.

Each radius grid presents radii at the specified pressure level, age, and atmospheric metallicity, while varying the rock/iron core mass, H/He mass fraction, and incident bolometric flux. The grids can be read using:

pd.read_csv({pressure}_{age}_{metallicity}.csv, comment='#')

For an overview of all grids, see Sub_Neptune_Radius_Grids.pdf. For additional details, please refer to the paper. For additional radii data not included in this repository, please contact yaotang@ucsc.edu.
DOI: 10.6084/m9.figshare.27252612.v9
title: Supplementary File 1.docx

description: The effectiveness of psychological interventions for women with polycystic ovary syndrome: A systematic review and meta-analysis - Supplementary Data File 1
DOI: 10.17632/rvdf8t77ck.1
title: Data of ZZ2 and ZZ9

description: This is the original data and analysis results of the transcriptome and metabolome analysis of two sugarcane varieties(ZZ2 and ZZ9).
DOI: 10.5281/zenodo.14847468
title: ARTIFICIAL INTELLIGENCE AND CYBERSECURITY
DOI: 10.5281/zenodo.14847469
title: ARTIFICIAL INTELLIGENCE AND CYBERSECURITY
DOI: 10.3886/e218902
title: IMLS Library Search & Compare

description: This dataset is downloaded from the Library Search and Compare dashboard on the IMLS website. Data is divided by years. Each row of the spreadsheet is an individual library. Indicators covered include visits, funding, resources/databases, programs and staff.
DOI: 10.3886/e218902v1
title: IMLS Library Search & Compare

description: This dataset is downloaded from the Library Search and Compare dashboard on the IMLS website. Data is divided by years. Each row of the spreadsheet is an individual library. Indicators covered include visits, funding, resources/databases, programs and staff.
DOI: 10.3886/e218903
title: IMLS PLS Benchmarking Tables

description: Downloaded tables from IMLS's interactive dashboard. Tables showcase 3 years’ worth of key indicators of public library use, financial health, staffing and resources at the national, state, and library service area levels. Each row in the spreadsheet represents a state.
DOI: 10.3886/e218903v1
title: IMLS PLS Benchmarking Tables

description: Downloaded tables from IMLS's interactive dashboard. Tables showcase 3 years’ worth of key indicators of public library use, financial health, staffing and resources at the national, state, and library service area levels. Each row in the spreadsheet represents a state.
DOI: 10.6084/m9.figshare.28077121.v1
title: Religion, spirituality, and DNA methylation in HPA-axis genes among Hispanic/Latino adults

description: Investigate associations between religion and spirituality (R&S) and DNA methylation of four HPA-axis genes (i.e. 14 CpG sites) among 992 adults from the Hispanic Community Health Study/Study of Latinos cohorts. We assessed 1) the association between R&S measures and mean percent methylation overall and stratified by nativity status (US-born or immigrant) and 2) if interactions between R&S and methylation differed by nativity status. Among individuals with the <i>FKBP5</i> CC genotype, increased spirituality scores were associated with significantly lower methylation levels among immigrants, compared to US-born participants. Organizational religiosity (e.g. service attendance) was associated with increased <i>FKBP5</i> (CC genotype) methylation among immigrants. R&S may influence HPA-axis functioning differently based on nativity status; a finding that could offer insight into mechanisms leading to health disparities. Hispanics/Latinos, the largest racial/ethnic minority group in the United States, face significant stressors and health challenges. Religion and spirituality are key sources of resilience, particularly for immigrants. However, the ways in which religion and spirituality influence genes related to health outcomes are not yet fully understood. In this study, we found that religion and spirituality impact a key gene in the body’s stress response system differently between immigrants and US-born individuals. We suggest that future research should explore how varying stressors and resilience factors affect these two groups, with the goal of improving health outcomes for all Hispanics/Latinos.