cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.17632/j22h832thx
title: Data for: Effects of Dieting Associated with Combined aerobic and Resistance Training program on Body Composition and Cardiovascular Disease Risk Factors among Obese Students with Metabolic Syndrome

description: Background: Diet and physical activity are the most commonly recommended strategies for preventing and treating metabolic syndrome (MetS). This randomized trial aims to examine the effectiveness of a weight reduction intervention based on caloric restriction, low-impact aerobics (LIA), and a resistance-training program in improving body composition, metabolic parameters and cardiovascular disease (CVD) risk factors among obese students diagnosed with MetS. Methods: In all, 23 male participants, aged 19-24 years, were randomly introduced to a dieting program (the diet group, or DG = 09) or to dieting associated with a supervised physical training program (the diet plus training group, or DTG = 14). Before and after the intervention, the participants' anthropometric measures and cardiovascular disease risk factors were assessed. Results: Following the interventions, significant improvements were noted in all anthropometric variables in all participants (p≤0.001 for all). Notable differences were observed between groups in terms of changes at WC (p ≤ 0.01), BFP (p≤ 0.05) and WHR (p≤ 0.05). All MetS components also improved in both groups, and the most significant improvements were observed among the training group in terms of fasting blood glucose (FBG) level (p ≤ 0.05), triglyceride (TG) level (p ≤ 0.001), total cholesterol (TC; p ≤ 0.01), low-density lipoprotein cholesterol (LDL-c; p ≤ 0.05), and very low-density lipoprotein cholesterol (VLDL-c; p ≤ 0.001). Conclusion: A daily caloric restriction of approximately -500 kcal could be an effective tool in combating MetS. Further, the introduction of three weekly aerobic and resistance-training sessions in a gymnasium to the caloric restriction program may deliver better outcomes, particularly in terms of reducing WC, BFP, WHR, FBG levels, TG levels, TC, LDL-c, and VLDL-c concentrations.
DOI: 10.6084/m9.figshare.19222533.v1
title: Population estimations based on 36 experiments for the city of Medellín, Colombia

description: Shapefile with the population estimations for the 36 experiments presented in Sapena et al. for the city of Medellín. The attribute table has one field per experiment. Where each value is the estimated population for the given tile based on the specific experiment. The names of the experiments can be found in Figure 4 (Sapena et al.). For example, the field "E1" is the estimated population based on the Medium resolution dasymetric disaggregation method, and the same for the rest. <br> This dataset allows to produce population maps for all the experiments using the different fields (E1-E36). <br> " Sapena M, Kühnl M, Wurm M, Patino JE, Duque JC, Taubenböck H (2022) Empiric recommendations for population disaggregation under different data scenarios. PLoS ONE 17(9): e0274504. https://doi.org/10.1371/journal.pone.0274504 "<br>
DOI: 10.6084/m9.figshare.21205952.v1
title: Supplementary Material for: The impact of breast awareness on the early detection of breast cancer in young women: A systematic review

description: Background ‘Breast awareness’ is a recommendation that women understand the symptoms of breast cancer and become familiar with the usual look and feel of their breasts. It is recommended for women of all ages in breast cancer screening guidelines around the world. The objective of this study was to assess the evidence for breast awareness by investigating its effect on breast cancer outcomes in women of pre-mammographic-screening age (under age 40), at average risk of breast cancer. Methods A systematic review was performed using PRISMA methodology. Following the search, abstracts and full text articles were assessed against eligibility criteria. Data were extracted into evidence tables, risk of bias was assessed, narrative synthesis was performed and results were described. Eligible studies were original research studies assessing the impact of breast awareness on cancer outcomes (such as stage at diagnosis or survival) in women ≤40. Medline, PubMed and Cochrane Library were searched. Results After screening the 6,204 abstracts identified in the search, no studies meeting all eligibility criteria were found. Two partially eligible studies were identified. These met the intervention and outcomes criteria but included mixed-age cohorts that included but were not limited to women ≤40. These studies provided low-level (Level IV) evidence of moderate quality that there is some benefit (earlier stage at diagnosis and/or improved survival) of breast awareness in a mixed-age cohort that included some younger women. Conclusions No studies evaluating the impact of breast awareness exclusively in young women were identified. Limited evidence of benefit of breast awareness was found. Guidelines that recommend breast awareness should be reviewed and qualified with an explanation that the evidence of benefit is weak. Women have limited screening options available to them for the early detection of breast cancer until they reach mammographic screening age. The study was registered on Prospero (ID: CRD42021279457).
DOI: 10.6084/m9.figshare.21345978.v1
title: Supplementary Material for: Retinopathy of Prematurity Is a Biomarker for Pathological Processes in the Immature Brain

description: <b><i>Introduction:</i></b> Retinopathy of prematurity (ROP) is considered a neurovascular disease. We investigated whether ROP, mild or severe, is associated with neurodevelopmental impairment (NDI) in extremely preterm children. <b><i>Methods:</i></b> We conducted a multicenter retrospective cohort study in southern Taiwan. A total of 394 children &lt;28 weeks of gestation who survived to discharge from 2011 to 2018 received neurodevelopmental assessment at corrected age of 24 months. Severe ROP was defined as ROP of stages 2 plus or worse, or recipients of retinal therapy, and mild ROP as stage 1 or 2 in at least one eye. NDI was defined as cognitive or motor impairment using the Bayley Scales of Infant and Toddler Development, moderate to severe cerebral palsy, or profound hearing loss. <b><i>Results:</i></b> Among the 374 children validated for analysis, 157 children (42%) had non-ROP, 145 (39%) mild ROP, and 72 (19%) severe ROP. As ROP severity increased progressively from non-ROP, to mild ROP, and to severe ROP, the rates of NDI increased from 25%, to 46%, and to 61%. The multivariable logistic regression showed that the model included three levels of ROP, and neonatal morbidities achieved better overall performance for NDI than the model that included neonatal morbidities alone. Compared with non-ROP, mild ROP and severe ROP had adjusted odds ratios of 1.90 (95% CI: 1.10–3.28) and 2.75 (95% CI: 1.33–5.67) for NDI, respectively. <b><i>Conclusion:</i></b> Mild ROP and severe ROP are independent neonatal morbidities associated with NDI. Neurodevelopmental follow-up of extremely preterm children with any stage of ROP is needed.
DOI: 10.6084/m9.figshare.28228787.v1
title: Data for Speißer et al. 2025 "Artificial particles and soil communities interactively change heterospecific plant-soil feedbacks".

description: The data refers to the publication Speißer et al. 2025 "Artificial particles and soil communities interactively change heterospecific plant-soil feedbacks", in which we report the results of an experiment in which we investigated the effects of different types of artificial particles (glass, different microplastics) on heterospecific plant-soil feedbacks.<br>
DOI: 10.6084/m9.figshare.28847039.v1
title: Datanights Workshop Data

description: <pre>This hands-on tutorial walks participants through building an automated evaluation pipeline for RAG applications. Using real examples, we’ll define key evaluation criteria and implement simple methods to assess LLM output quality—focusing on completeness, relevance, and hallucinations. Presented at DataNights Course.</pre>
DOI: 10.17632/ymrs93b9c9
title: Stepwise Requirements for Polymerases Theta and Delta in TMEJ  (Untreated samples)

description: Coordinate data for STORM performed in association with DOI: https://doi.org/10.21203/rs.3.rs-2057977. Untreated RPE1 cells expressing a HALO-tagged POLQ. 53BP1 was imaged in green, HALO-POLQ in red, EdU in dark red, and POLD1 in blue.
DOI: 10.6084/m9.figshare.12760214.v1
title: Decreased excitability of motor axons contributes substantially to contraction fatigability during neuromuscular electrical stimulation.

description: These data files accompany a paper submitted for publication to Applied Physiology, Nutrition, and Metabolism. Neuromuscular electrical stimulation, or NMES, is a technique used for rehabilitation, maintenance of physical activity, and functional neuroprosthetic applications (e.g. to compensate for foot drop). The contraction of the muscles intermittently activated by NMES may start <i>strong</i> and functional but rapidly weaken; a process we refer to as contraction fatigability. Historically we along with our peers have considered that the muscle itself and the recruitment of motor units in the muscle during NMES are the primary mechanisms underlying the rate that contraction fatigability develops. We demonstrate in this paper that the excitability of the motor axons innervating the muscle are equally, if not more, important than the muscle properties during these types of contractions.
DOI: 10.6084/m9.figshare.16817407
title: Supplementary Material for: Efficacy of Photodynamic Therapy for the Treatment of Bowen’s Disease: A Meta-Analysis of Randomized Controlled Trials

description: <b><i>Background:</i></b> Photodynamic therapy is an established treatment option for Bowen’s disease. Our meta-analysis was aimed at evaluating the efficacy and recurrence of photodynamic therapy or other topical treatments (5-fluorouracil, cryotherapy) and of photodynamic therapy alone or in combination with other therapies (ablative fractional CO<sub>2</sub> laser or plum-blossom needle) for the treatment of Bowen’s disease. <b><i>Methods:</i></b> Trials that met our inclusion criteria were identified from PubMed, EMBASE, Web of Science, and Cochrane Library databases, and meta-analyses were conducted with RevMan V.5.4. The risk of bias was estimated with the Cochrane Collaboration’s risk of bias tools. Complete response rate, recurrence, pain/visual analogue scale score, cosmetic outcome, and adverse events were considered as outcomes. <b><i>Results:</i></b> Of the 2,439 records initially retrieved, 8 randomized controlled trials were included in this meta-analysis. According to our analyses, photodynamic therapy exhibited a significantly higher complete response rate (RR = 1.36, 95% CI [1.01, 1.84], <i>I</i><sup>2</sup> = 86%, <i>p</i> = 0.04), less recurrence (RR = 0.53, 95% CI [0.30, 0.95], <i>I</i><sup>2</sup> = 0%, <i>p</i> = 0.03), and better cosmetic outcome (RR = 1.34, 95% CI [1.15, 1.56], <i>I</i><sup>2</sup> = 0%, <i>p</i> = 0.0002) compared with other treatments. Moreover, there was a significant difference between the complete response rate of photodynamic therapy combined with ablative fractional CO<sub>2</sub> laser and that of photodynamic therapy (RR = 1.85, 95% CI [1.38, 2.49], <i>I</i><sup>2</sup> = 0%, <i>p</i> &lt; 0.0001). Photodynamic therapy combined with ablative fractional CO<sub>2</sub> laser or plum-blossom needle also showed significantly less recurrence (RR = 0.21, 95% CI [0.09, 0.51], <i>I</i><sup>2</sup> = 0%, <i>p</i> = 0.0005) and a lower visual analogue scale score (RR = 0.51, 95% CI [0.06, 0.96], <i>I</i><sup>2</sup> = 0%, <i>p</i> = 0.03) than photodynamic therapy alone. However, there was no significant difference in the complete response rate between photodynamic therapy combined with ablative continuous CO<sub>2</sub> laser and photodynamic therapy combined with ablative fractional CO<sub>2</sub> laser (RR = 1.00, 95% CI [0.54, 1.86], <i>I</i><sup>2</sup> not applicable, <i>p</i> = 1.00). <b><i>Conclusions:</i></b> This meta-analysis shows that photodynamic therapy can be used in the treatment of Bowen’s disease with better efficacy, less recurrence, and better cosmetic outcomes than cryotherapy and 5-FU. Some methods, including ablative fractional CO<sub>2</sub> laser, can be applied in combination with photodynamic therapy to improve efficacy. However, which laser-assisted photodynamic therapy scheme has the most advantages in the treatment of Bowen’s disease warrants further exploration.
DOI: 10.6084/m9.figshare.20013263.v1
title: Supplementary Material for: Mannan-Binding Lectin Reduces Epithelial-Mesenchymal Transition in Pulmonary Fibrosis via Inactivating the Store-Operated Calcium Entry Machinery

description: Idiopathic pulmonary fibrosis (IPF) is a type of idiopathic interstitial pneumonia with a poor clinical prognosis. Increasing evidence has demonstrated that epithelial-mesenchymal transition (EMT) contributes to the production of pathogenic myofibroblasts and plays a pivotal role in the development of pulmonary fibrosis. Mannan-binding lectin (MBL) is a soluble calcium-dependent complement molecule. Several studies have reported associations between serum MBL levels and lung diseases; however, the effect of MBL on IPF remains unknown. The present study observed aggravated pulmonary fibrosis in bleomycin-treated MBL<sup>−/−</sup> mice compared with their wild-type counterparts. Lung tissues from bleomycin-treated MBL<sup>−/−</sup> mice displayed a more severe EMT phenotype. In vitro studies determined that MBL inhibited the EMT process through attenuating store-operated calcium entry (SOCE) signaling. It was further demonstrated that MBL promoted the ubiquitination of Orai1, an essential component of SOCE, via pyruvate dehydrogenase kinase 1 (PDK1)-serum glucocorticoid-regulated kinase 1 signaling. PDK1 inhibition abolished the MBL-mediated regulation of SOCE activity and the EMT process. Notably, biochemical analysis showed that MBL interacted with PDK1 and contributed to PDK1 ubiquitination. In summary, the present findings suggested that MBL limited the EMT phenotype in human alveolar epithelial cells through regulation of SOCE, and MBL could be recognized as a potential therapeutic target for IPF.
DOI: 10.6084/m9.figshare.7942439.v1
title: Dimensioning of the physical area and required number of food handlers for school food services

description: ABSTRACT Objective We aimed to establish equations for dimensioning of the physical area and determining the required number of food handlers in food services of schools and to compare them with reference equations. Methods It was visited 44 municipalities located in the states of São Paulo (n=36) and Rio de Janeiro (n=8) between 2013 and 2014. The physical area for school food services was evaluated using a measuring tape. For all food services, we calculated the Maximum Attendance Capacity, which is the sum of small and large meals served during the busiest shift. A validated checklist was used to evaluate food safety practices. Linear regression models were developed to establish the proposed equations. Results In total, we evaluated 205 school units. Based on the data, the following equations were established: Equation A: area of production=15.22+(maximum attendance capacity×0.02), which estimates the minimum area needed for a school food service; and Equation B: the number of food handlers=2.17+(maximum attendance capacity×0.002), to determine the minimum number of food handlers needed. These equations were established based on school food services that presented adequate food safety practices (i.e., low health risk). Conclusion It was established new equations for calculating the size of the physical area for school food services and the required number of food handlers. These new equations can be used as a starting point in management planning of a school food service.
DOI: 10.17632/d7hkxk3hr4
title: Raw data - Differential association between the progression of coronary artery calcium score and coronary plaque volume progression according to statins: the Progression of AtheRosclerotic PlAque DetermIned by CTA Imaging (PARADIGM) study

description: Research data
DOI: 10.6084/m9.figshare.13352681.v1
title: Supplementary Material for: <b><i>MMP9</i></b> rs17576 Is Simultaneously Correlated with Symptomatic Intracranial Atherosclerotic Stenosis and White Matter Hyperintensities in Chinese Population

description: <b><i>Purpose:</i></b> The aim of this study was screening for single nucleotide polymorphisms (SNPs) associated with white matter hyperintensities (WMHs) in symptomatic intracranial atherosclerotic stenosis (sICAS) patients and exploring a possible connection in the genetic background between macrovascular disease and small vessel disease. <b><i>Methods:</i></b> There were 400 sICAS patients enrolled in the study. Fazekas scores were applied to WMH classification. Healthy controls were referred to 1,000 Genome Project and GeneSky company who provided 1,007 Chinese healthy controls. Fast target sequencing technology was used to select the SNPs of 102 genes related to the pathogenesis of sICAS in the sICAS patients. <b><i>Results:</i></b> The allele frequencies of 88 SNPs were significantly different between the sICAS group and the healthy controls (<i>p</i> &lt; 0.05). The allele frequencies of 53 SNPs were significantly different between the sICAS patients with and without WMHs (<i>p</i> &lt; 0.05). Further analysis found that matrix metalloproteinase 9 (<i>MMP9</i>) rs17576 was simultaneously related to sICAS and WMHs. The frequency of the rs17576 A allele was significantly lower in sICAS patients when compared to the normal controls (<i>p</i> = 0.03, OR [95% CI] = 0.75 [0.625–0.91]). Also, the frequency of the rs17576 genotypes was significantly different under codominant (<i>p</i> = 0.009), dominant (<i>p</i> = 0.014), and recessive (<i>p</i>= 0.023) models. The frequency of the rs17576 A allele was significantly higher in sICAS with WMH patients, compared to those without WMHs (<i>p</i> = 0.022, OR [95% CI] = 1.54 [1.06–2.22]); the frequency of the rs17576 genotypes was significantly different under codominant (<i>p</i> = 0.019) and recessive (<i>p</i> = 0.032) models. Logistic regression analysis showed that age, hypertension, and <i>MMP9</i> rs17576 AA genotype were independent risk factors for sICAS with WMHs. <b><i>Conclusion:</i></b> <i>MMP9</i> rs17576 may be simultaneously associated with the risk of sICAS and WMHs.
DOI: 10.17632/5dvzpv5f8c
title: Data S1_Torres et al_Cell_Mining human microbiomes reveals an untapped source of peptide antibiotics

description: Data S1. (a) List of 323 smORF-encoded candidate peptides with predicted antimicrobial activity, related to Figure 1. (b) BLASTn results of the 323 predicted SEPs top hits organisms based on highest percent identity for every query as the putative source organism. (c) List of SEPs identified as transcribed and translated based on normalized read coverage of the SEP coding region in RNA-seq and MetaRibo-seq.
DOI: 10.17632/738h3y3mh8
title: Decision Aid for Lentigo Maligna

description: The Decision Aid for Lentigo Maligna was developed by members of the American Society for Dermatologic Surgery with iterative feedback from patients. It contains evidence-based information regarding LM and various treatment modalities, including surgery, imiquimod 5%, radiation, as well as active surveillance. Treatment-specific information includes treatment efficacy, advantages and adverse effects, expected follow up, and estimated associated costs. The “things I might consider in my decision” section of the decision aid contains questions regarding lifestyle, comorbidities, social factors, and disease-related concerns.
DOI: 10.17632/3j5dyhdhxp
title: Poly-ADP-ribosylation enhances nucleosome dynamics and organizes DNA damage repair components within biomolecular condensates

description: Uncropped, uncompressed imaging data, including gel images and micrographs, from the manuscript, "Poly-ADP-ribosylation enhances nucleosome dynamics and organizes DNA damage repair components within biomolecular condensates", currently under revision (Oct 30, 2023).
DOI: 10.17632/g58vhcykcj
title: Sediment load under diverse climate change scenarios

description: Climate change directly affects the intensity of surface erosion and the sediment load in rivers. Currently, there are many climate models in use in Europe, and their forecasts differ to some extent. This means that the selection of models and their ensembles in environmental analyzes will directly translate into the predicted sediment load, which is important for mitigating the siltation of rivers and dammed reservoirs.
Using the SWAT model [1,2,3], we performed research on the impact of adopting various climate models [4] on the sediment load flowing into the dammed reservoir. We included three types of comparison:
A. We adopted point forecasts for the nearest large city – Kraków [5] and areal forecasts for the catchment.
B. We compared the adopted reference period, which is a source of precipitation change for the climate scenarios.
C. We have put together various types of ensembles - consisting of wet and dry models [6].
We present the research results in individual sheets of the included Excel file. The file contains four sheets:
1.Location:
We present a graphic of the location of the calculation point for which the research was carried out. It contains a map of Poland and the Carpathian Mountains with the studied catchment marked (red). The next drawing highlights the analyzed catchment area of the upper Raba River flowing into the dammed reservoir (Dobczyce). The graphics also include data source setup for which point and areal approach scenarios were performed. The third figure on the graphic is the results of modeling average monthly sediment load for base scenario against the average precipitation monthly sums.
2. Climate change predictions:
First, the reader should pay attention to the graphics. They present all implemented scenarios (outer circle with corresponding colors) and the way they are named (inside the circle). It also includes which scenarios belong to the point (P) and areal (A) approaches, and what was the reference period (10 or 30 years). The table in this sheet presents the changes of precipitation introduced in the model using the delta change tool in the model SWAT.
3. Scenarios Database - Av.:
The spreadsheet presents the modeling results as average monthly sediment loads for each scenario. The data are presented in a table and a chart enabling quick comparison of annual cycle trends and their changes in various scenarios.
4. Scenarios Database - Y:
The last sheet presents the full monthly sediment load data sets for all scenarios. The reader's attention is focused on the interactive pivot chart. The user should select the scenarios of interest, years or months. It is then possible to thoroughly analyze changes in the modeling results of individual monthly values and time shifts resulting from the introduction of various types of ensemble climate models. In the background there are values that can be used by the reader for their own comparative analyses, provided that the source of the data is properly cited.