cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.5607109
title: Supplementary Material for: Exploring the Association between Statin Use and the Risk of Parkinson’s Disease: A Meta-Analysis of Observational Studies

description: <b><i>Background:</i></b> Parkinson’s disease (PD) is a progressive disorder of the central nervous system. The prevalence of PD varies considerably by age group; it has a higher prevalence in patients aged 60 years and more. Several studies have shown that statin, a cholesterol-lowering medication, reduces the risk of developing PD, but evidence for this is so far inconclusive. The objective of this study is to evaluate the association between statin use and the risk of developing PD. <b><i>Methods:</i></b> PubMed, EMBASE, and the bibliographies of articles were searched for studies<b><i></i></b> published between January 1, 1990, and January 1, 2017, which reported on the association between statin use and PD. Articles were included if they (1) were published in English, (2) reported patients treated with statin, and the outcome of interest was PD, (3) provided OR/HR with 95% CI or sufficient information to calculate the 95% CI. All abstracts, full-text articles, and sources were reviewed, with duplicate data excluded. Summary relative risk (RRs) with 95% CI was pooled using a random-effects model. Subgroup and sensitivity analyses were also conducted. <b><i>Results:</i></b> We selected 16 out of 529 unique abstracts for full-text review using our selection criteria, and 13 out of these 16 studies, comprising 4,877,059 persons, met all of our inclusion criteria. The overall pooled RR of PD was 0.70 (95% CI 0.58–0.84) with significant heterogeneity between estimates (<i>I</i><sup>2</sup> = 93.41%, <i>p</i> = 0.000) for the random-effects model. In subgroup analysis, the greater decreased risk was found in studies from Asia (RR 0.62 95% CI 0.51–0.76), whereas a moderate reduction was observed in studies from North America (RR 0.69 95% CI 0.47–1.00), but less reduction was observed in studies from Europe (RR 0.86 95% CI 0.80–0.92). Also, long-term statin use, simvastatin, and atorvastatin showed a higher rate of reduction with significance heterogeneity. <b><i>Conclusion:</i></b> Our results showed that statin use is significantly associated with a lower risk of<b><i></i></b> developing PD. Physicians should consider statin drug therapy, monitor its outcomes, and empower their patients to improve their knowledge, therapeutic outcomes, and quality of life. However, preventive measures and their associated mechanisms must be further assessed and explored.
DOI: 10.6084/m9.figshare.5607127.v1
title: Geochemical and foraminiferal data. Influence of dominant wind patterns in a distal region of the NW Iberian Margin during the last glaciation

description: Geochemical and foraminiferal data.
DOI: 10.6084/m9.figshare.5607106
title: Supplementary Material for: Inflammatory and Angiogenic Factors Linked to Longitudinal Microvascular Changes in Hemodialysis Patients Irrespective of Treatment Dose Intensity

description: <b><i>Background:</i></b> Cardiovascular disease is a major contributor to the poor outcomes observed in hemodialysis. We investigated the relationship between hemodialysis intensity and vascular parameters in high-dose (HDHD; &gt;12hrs/week) and Conventional (CHD; ≤12hrs/week) hemodialysis intensity over a 6-month period. <b><i>Methods:</i></b> We present the 6-month longitudinal analysis of a 2-year multicenter study investigating the effects of HDHD on cardiovascular parameters. We used pulse wave velocity, 24hr ambulatory blood pressure and sublingual dark field capillaroscopy measurements to assess macro- and microcirculation on 6-monthly basis. Pro-inflammatory and endothelial biomarkers were also measured at 6-monthly intervals. <b><i>Results:</i></b> 47 participants (21 HDHD, 26 CHD) were studied. CHD were older (63.5±14.2 vs 53.7±12.6 yr; p=0.018), with shorter dialysis vintage (median 23 vs 61 months; p=0.001). There was considerable variability in the degree and direction of change of circulatory measurements over a 6-month period. Hemodialysis intensity (hrs/week) did not correlate to these changes, when adjusted for age, dialysis vintage and comorbidity. Higher levels of Interleukin (IL)-8 measured at baseline independently predicted an increase in the Perfused Boundary Region (5-25μm) of the endothelial glycocalyx (p=0.010) whilst higher levels of soluble Flt-1 had a significant inverse effect (p=0.002) in an adjusted linear model. <b><i>Conclusion:</i></b> Hemodialysis intensity did not predict changes in either macro- or microvascular parameters. Inflammation mediated through the IL-8 pathway predicted microvascular injury while Flt-1, a potential marker of angiogenesis and endothelial repair, might have a significant protective role. Further understanding of these pathways will be necessary to improve dialysis outcomes.
DOI: 10.6084/m9.figshare.5607109.v1
title: Supplementary Material for: Exploring the Association between Statin Use and the Risk of Parkinson’s Disease: A Meta-Analysis of Observational Studies

description: <b><i>Background:</i></b> Parkinson’s disease (PD) is a progressive disorder of the central nervous system. The prevalence of PD varies considerably by age group; it has a higher prevalence in patients aged 60 years and more. Several studies have shown that statin, a cholesterol-lowering medication, reduces the risk of developing PD, but evidence for this is so far inconclusive. The objective of this study is to evaluate the association between statin use and the risk of developing PD. <b><i>Methods:</i></b> PubMed, EMBASE, and the bibliographies of articles were searched for studies<b><i></i></b> published between January 1, 1990, and January 1, 2017, which reported on the association between statin use and PD. Articles were included if they (1) were published in English, (2) reported patients treated with statin, and the outcome of interest was PD, (3) provided OR/HR with 95% CI or sufficient information to calculate the 95% CI. All abstracts, full-text articles, and sources were reviewed, with duplicate data excluded. Summary relative risk (RRs) with 95% CI was pooled using a random-effects model. Subgroup and sensitivity analyses were also conducted. <b><i>Results:</i></b> We selected 16 out of 529 unique abstracts for full-text review using our selection criteria, and 13 out of these 16 studies, comprising 4,877,059 persons, met all of our inclusion criteria. The overall pooled RR of PD was 0.70 (95% CI 0.58–0.84) with significant heterogeneity between estimates (<i>I</i><sup>2</sup> = 93.41%, <i>p</i> = 0.000) for the random-effects model. In subgroup analysis, the greater decreased risk was found in studies from Asia (RR 0.62 95% CI 0.51–0.76), whereas a moderate reduction was observed in studies from North America (RR 0.69 95% CI 0.47–1.00), but less reduction was observed in studies from Europe (RR 0.86 95% CI 0.80–0.92). Also, long-term statin use, simvastatin, and atorvastatin showed a higher rate of reduction with significance heterogeneity. <b><i>Conclusion:</i></b> Our results showed that statin use is significantly associated with a lower risk of<b><i></i></b> developing PD. Physicians should consider statin drug therapy, monitor its outcomes, and empower their patients to improve their knowledge, therapeutic outcomes, and quality of life. However, preventive measures and their associated mechanisms must be further assessed and explored.
DOI: 10.17045/sthlmuni.5607112.v1
title: Species richness and composition differ in response to landscape and biogeography: data from Stockholm (outer) Archipelago (Baltic Sea), summer months 2009-2010.

description: Data for "Species richness and composition differ in response to landscape and biogeography" by Aggemyr, Auffret, Jädergård and Cousins.<br>The plant survey was conducted during the summers of 2009 and 2010 in the outher archipleago of Stockholm, Baltic Sea. A total of 112 islands are included in the data.<br><br>The data includes:"2009-2010Baltic_explanatoryVariables.csv" - explanatory variables from 112 islands: island area, height, group, distance to mainland, shannon diversity index for habitat heterogeneity, structural connectivity for buffer radii 100, 1000, and 4000 metres, and also geographical position in WGS84.<br>"2009-2010Baltic_speciesComposition.csv" - a matrix of species presence/absence on each island.<br>"2009-2010Baltic_speciesRichness.csv" - number of species on each island.<br>"2009-2010Baltic_lifeFormClassification.csv" - species classified into four different life forms.<br>"2009-2010Baltic_map.jpg" - a map illustrating Stockholm archipelago, Baltic Sea, and the surveyed islands.<br>"2009-2010Baltic_readMe.txt" - a more detailed file description.<br><br>Please feel free to get in touch!<br>
DOI: 10.6084/m9.figshare.5607076
title: ML8 - Mean minimum monthly flows

description: IHA metric describing mean minimum monthly flow in m3 s-1. Covering 64 years (1950-2013) for German stream network (1km grid cells)
DOI: 10.6084/m9.figshare.5607124.v1
title: Finite difference methods for stationary and time-dependent x-ray propagation - Propagation errors

description: Observes convergence behaviour of different propagation algorithms. Generates Fig. 2 in the upcoming publication ''Finite difference methods for stationary and time-dependent x-ray propagation''.
DOI: 10.6084/m9.figshare.5607067
title: ML12 - Mean minimum monthly flows

description: IHA metric describing mean minimum monthly flow in m3 s-1. Covering 64 years (1950-2013) for German stream network (1km grid cells)
DOI: 10.6084/m9.figshare.5607073
title: TA2 - Predictability of flow

description: IHA metric composed of two independent, additive components: constancy (a measure of temporal invariance) and contingency (a measure of periodicity). dimensionless. Covering 64 years (1950-2013) for German stream network (1km grid cells)
DOI: 10.6084/m9.figshare.5607076.v1
title: ML8 - Mean minimum monthly flows

description: IHA metric describing mean minimum monthly flow in m3 s-1. Covering 64 years (1950-2013) for German stream network (1km grid cells)
DOI: 10.6084/m9.figshare.5607061
title: ML10 - Mean minimum monthly flows

description: IHA metric describing mean minimum monthly flow in m3 s-1. Covering 64 years (1950-2013) for German stream network (1km grid cells)
DOI: 10.6084/m9.figshare.5607058
title: ML9 - Mean minimum monthly flows

description: IHA metric describing mean minimum monthly flow in m3 s-1. Covering 64 years (1950-2013) for German stream network (1km grid cells)
DOI: 10.6084/m9.figshare.5607064
title: ML11 - Mean minimum monthly flows

description: IHA metric describing mean minimum monthly flow in m3 s-1. Covering 64 years (1950-2013) for German stream network (1km grid cells)
DOI: 10.6084/m9.figshare.5607067.v1
title: ML12 - Mean minimum monthly flows

description: IHA metric describing mean minimum monthly flow in m3 s-1. Covering 64 years (1950-2013) for German stream network (1km grid cells)
DOI: 10.6084/m9.figshare.5607073.v1
title: TA2 - Predictability of flow

description: IHA metric composed of two independent, additive components: constancy (a measure of temporal invariance) and contingency (a measure of periodicity). dimensionless. Covering 64 years (1950-2013) for German stream network (1km grid cells)
DOI: 10.6084/m9.figshare.5607055
title: ML7 - Mean minimum monthly flows

description: IHA metric describing mean minimum monthly flow in m3 s-1. Covering 64 years (1950-2013) for German stream network (1km grid cells)
DOI: 10.6084/m9.figshare.5607055.v1
title: ML7 - Mean minimum monthly flows

description: IHA metric describing mean minimum monthly flow in m3 s-1. Covering 64 years (1950-2013) for German stream network (1km grid cells)
DOI: 10.6084/m9.figshare.5607058.v1
title: ML9 - Mean minimum monthly flows

description: IHA metric describing mean minimum monthly flow in m3 s-1. Covering 64 years (1950-2013) for German stream network (1km grid cells)
DOI: 10.6084/m9.figshare.5607061.v1
title: ML10 - Mean minimum monthly flows

description: IHA metric describing mean minimum monthly flow in m3 s-1. Covering 64 years (1950-2013) for German stream network (1km grid cells)
DOI: 10.6084/m9.figshare.5607064.v1
title: ML11 - Mean minimum monthly flows

description: IHA metric describing mean minimum monthly flow in m3 s-1. Covering 64 years (1950-2013) for German stream network (1km grid cells)
DOI: 10.6084/m9.figshare.5607043
title: ML4 - Mean minimum monthly flows

description: IHA metric describing mean minimum monthly flow in m3 s-1. Covering 64 years (1950-2013) for German stream network (1km grid cells)
DOI: 10.6084/m9.figshare.5607046
title: ML5 - Mean minimum monthly flows

description: IHA metric describing mean minimum monthly flow in m3 s-1. Covering 64 years (1950-2013) for German stream network (1km grid cells)
DOI: 10.6084/m9.figshare.5607049
title: MH9 - Mean maximum monthly flows

description: IHA metric describing mean maximum monthly flow in m3 s-1. Covering 64 years (1950-2013) for German stream network (1km grid cells)
DOI: 10.6084/m9.figshare.5607052
title: ML6 - Mean minimum monthly flows

description: IHA metric describing mean minimum monthly flow in m3 s-1. Covering 64 years (1950-2013) for German stream network (1km grid cells)
DOI: 10.6084/m9.figshare.5607040
title: ML2 - Mean minimum monthly flows

description: IHA metric describing mean minimum monthly flow in m3 s-1. Covering 64 years (1950-2013) for German stream network (1km grid cells)
DOI: 10.6084/m9.figshare.5607052.v1
title: ML6 - Mean minimum monthly flows

description: IHA metric describing mean minimum monthly flow in m3 s-1. Covering 64 years (1950-2013) for German stream network (1km grid cells)
DOI: 10.6084/m9.figshare.5607040.v1
title: ML2 - Mean minimum monthly flows

description: IHA metric describing mean minimum monthly flow in m3 s-1. Covering 64 years (1950-2013) for German stream network (1km grid cells)
DOI: 10.6084/m9.figshare.5607043.v1
title: ML4 - Mean minimum monthly flows

description: IHA metric describing mean minimum monthly flow in m3 s-1. Covering 64 years (1950-2013) for German stream network (1km grid cells)
DOI: 10.6084/m9.figshare.5607031
title: TA1 - Constancy

description: IHA metric that describes a measure of temporal invariance. dimensionless. Covering 64 years (1950-2013) for German stream network (1km grid cells)
DOI: 10.6084/m9.figshare.5607034
title: ML1 - Mean minimum monthly flows

description: IHA metric describing mean minimum monthly flow in m3 s-1. Covering 64 years (1950-2013) for German stream network (1km grid cells)
DOI: 10.6084/m9.figshare.5607037
title: ML3 - Mean minimum monthly flows

description: IHA metric describing mean minimum monthly flow in m3 s-1. Covering 64 years (1950-2013) for German stream network (1km grid cells)
DOI: 10.6084/m9.figshare.5607046.v1
title: ML5 - Mean minimum monthly flows

description: IHA metric describing mean minimum monthly flow in m3 s-1. Covering 64 years (1950-2013) for German stream network (1km grid cells)
DOI: 10.6084/m9.figshare.5607028
title: RA3 - Fall rate

description: IHA metric that describes mean rate of negative changes in flow from one day to the next in m3 s-1 d-1. Covering 64 years (1950-2013) for German stream network (1km grid cells)
DOI: 10.6084/m9.figshare.5607034.v1
title: ML1 - Mean minimum monthly flows

description: IHA metric describing mean minimum monthly flow in m3 s-1. Covering 64 years (1950-2013) for German stream network (1km grid cells)
DOI: 10.6084/m9.figshare.5607031.v1
title: TA1 - Constancy

description: IHA metric that describes a measure of temporal invariance. dimensionless. Covering 64 years (1950-2013) for German stream network (1km grid cells)
DOI: 10.6084/m9.figshare.5607019
title: MH10 - Mean maximum monthly flows

description: IHA metric describing mean maximum monthly flow in m3 s-1. Covering 64 years (1950-2013) for German stream network (1km grid cells)
DOI: 10.6084/m9.figshare.5607022
title: MH11 - Mean maximum monthly flows

description: IHA metric describing mean maximum monthly flow in m3 s-1. Covering 64 years (1950-2013) for German stream network (1km grid cells)
DOI: 10.6084/m9.figshare.5607025
title: RA1 - Rise rate

description: IHA metric that describes mean rate of positive changes in flow from one day to the next in m3 s-1 d-1. Covering 64 years (1950-2013) for German stream network (1km grid cells)
DOI: 10.6084/m9.figshare.5607037.v1
title: ML3 - Mean minimum monthly flows

description: IHA metric describing mean minimum monthly flow in m3 s-1. Covering 64 years (1950-2013) for German stream network (1km grid cells)
DOI: 10.6084/m9.figshare.5607016
title: MH12 - Mean maximum monthly flows

description: IHA metric describing mean maximum monthly flow in m3 s-1. Covering 64 years (1950-2013) for German stream network (1km grid cells)
DOI: 10.6084/m9.figshare.5607016.v1
title: MH12 - Mean maximum monthly flows

description: IHA metric describing mean maximum monthly flow in m3 s-1. Covering 64 years (1950-2013) for German stream network (1km grid cells)
DOI: 10.6084/m9.figshare.5607025.v1
title: RA1 - Rise rate

description: IHA metric that describes mean rate of positive changes in flow from one day to the next in m3 s-1 d-1. Covering 64 years (1950-2013) for German stream network (1km grid cells)
DOI: 10.6084/m9.figshare.5607028.v1
title: RA3 - Fall rate

description: IHA metric that describes mean rate of negative changes in flow from one day to the next in m3 s-1 d-1. Covering 64 years (1950-2013) for German stream network (1km grid cells)
DOI: 10.6084/m9.figshare.5607019.v1
title: MH10 - Mean maximum monthly flows

description: IHA metric describing mean maximum monthly flow in m3 s-1. Covering 64 years (1950-2013) for German stream network (1km grid cells)
DOI: 10.6084/m9.figshare.5607007
title: MH7 - Mean maximum monthly flows

description: IHA metric describing mean maximum monthly flow in m3 s-1. Covering 64 years (1950-2013) for German stream network (1km grid cells)
DOI: 10.6084/m9.figshare.5607010
title: MH1 - Mean maximum monthly flows

description: IHA metric describing mean maximum monthly flow in m3 s-1. Covering 64 years (1950-2013) for German stream network (1km grid cells)
DOI: 10.6084/m9.figshare.5607013
title: MH8 - Mean maximum monthly flows

description: IHA metric describing mean maximum monthly flow in m3 s-1. Covering 64 years (1950-2013) for German stream network (1km grid cells)
DOI: 10.6084/m9.figshare.5607022.v1
title: MH11 - Mean maximum monthly flows

description: IHA metric describing mean maximum monthly flow in m3 s-1. Covering 64 years (1950-2013) for German stream network (1km grid cells)
DOI: 10.6084/m9.figshare.5607001
title: MH6 - Mean maximum monthly flows

description: IHA metric describing mean maximum monthly flow in m3 s-1. Covering 64 years (1950-2013) for German stream network (1km grid cells)
DOI: 10.6084/m9.figshare.5607004
title: MH4 - Mean maximum monthly flows

description: IHA metric describing mean maximum monthly flow in m3 s-1. Covering 64 years (1950-2013) for German stream network (1km grid cells)
DOI: 10.6084/m9.figshare.5607004.v1
title: MH4 - Mean maximum monthly flows

description: IHA metric describing mean maximum monthly flow in m3 s-1. Covering 64 years (1950-2013) for German stream network (1km grid cells)
DOI: 10.6084/m9.figshare.5607007.v1
title: MH7 - Mean maximum monthly flows

description: IHA metric describing mean maximum monthly flow in m3 s-1. Covering 64 years (1950-2013) for German stream network (1km grid cells)
DOI: 10.6084/m9.figshare.5607010.v1
title: MH1 - Mean maximum monthly flows

description: IHA metric describing mean maximum monthly flow in m3 s-1. Covering 64 years (1950-2013) for German stream network (1km grid cells)
DOI: 10.6084/m9.figshare.5607013.v1
title: MH8 - Mean maximum monthly flows

description: IHA metric describing mean maximum monthly flow in m3 s-1. Covering 64 years (1950-2013) for German stream network (1km grid cells)
DOI: 10.6084/m9.figshare.5606998
title: MH5 - Mean maximum monthly flows

description: IHA metric describing mean maximum monthly flow in m3 s-1. Covering 64 years (1950-2013) for German stream network (1km grid cells)
DOI: 10.6084/m9.figshare.5606989
title: MA23 - Mean monthly flows

description: IHA metric describing mean monthly flow in m3 s-1. Covering 64 years (1950-2013) for German stream network (1km grid cells)
DOI: 10.6084/m9.figshare.5606992
title: MH3 - Mean maximum monthly flows

description: IHA metric describing mean maximum monthly flow in m3 s-1. Covering 64 years (1950-2013) for German stream network (1km grid cells)
DOI: 10.6084/m9.figshare.5606995
title: MH2 - Mean maximum monthly flows

description: IHA metric describing mean maximum monthly flow in m3 s-1. Covering 64 years (1950-2013) for German stream network (1km grid cells)
DOI: 10.6084/m9.figshare.5606992.v1
title: MH3 - Mean maximum monthly flows

description: IHA metric describing mean maximum monthly flow in m3 s-1. Covering 64 years (1950-2013) for German stream network (1km grid cells)
DOI: 10.6084/m9.figshare.5606995.v1
title: MH2 - Mean maximum monthly flows

description: IHA metric describing mean maximum monthly flow in m3 s-1. Covering 64 years (1950-2013) for German stream network (1km grid cells)
DOI: 10.6084/m9.figshare.5606998.v1
title: MH5 - Mean maximum monthly flows

description: IHA metric describing mean maximum monthly flow in m3 s-1. Covering 64 years (1950-2013) for German stream network (1km grid cells)
DOI: 10.6084/m9.figshare.5606980
title: MA20 - Mean monthly flows

description: IHA metric describing mean monthly flow in m3 s-1. Covering 64 years (1950-2013) for German stream network (1km grid cells)
DOI: 10.6084/m9.figshare.5606983
title: MA21 - Mean monthly flows

description: IHA metric describing mean monthly flow in m3 s-1. Covering 64 years (1950-2013) for German stream network (1km grid cells)
DOI: 10.6084/m9.figshare.5606986
title: MA22 - Mean monthly flows

description: IHA metric describing mean monthly flow in m3 s-1. Covering 64 years (1950-2013) for German stream network (1km grid cells)
DOI: 10.6084/m9.figshare.5606989.v1
title: MA23 - Mean monthly flows

description: IHA metric describing mean monthly flow in m3 s-1. Covering 64 years (1950-2013) for German stream network (1km grid cells)
DOI: 10.6084/m9.figshare.5606977
title: MA18 - Mean monthly flows

description: IHA metric describing mean monthly flow in m3 s-1. Covering 64 years (1950-2013) for German stream network (1km grid cells)
DOI: 10.6084/m9.figshare.5606980.v1
title: MA20 - Mean monthly flows

description: IHA metric describing mean monthly flow in m3 s-1. Covering 64 years (1950-2013) for German stream network (1km grid cells)
DOI: 10.6084/m9.figshare.5606986.v1
title: MA22 - Mean monthly flows

description: IHA metric describing mean monthly flow in m3 s-1. Covering 64 years (1950-2013) for German stream network (1km grid cells)
DOI: 10.6084/m9.figshare.5606974
title: MA19 - Mean monthly flows

description: IHA metric describing mean monthly flow in m3 s-1. Covering 64 years (1950-2013) for German stream network (1km grid cells)
DOI: 10.6084/m9.figshare.5606977.v1
title: MA18 - Mean monthly flows

description: IHA metric describing mean monthly flow in m3 s-1. Covering 64 years (1950-2013) for German stream network (1km grid cells)
DOI: 10.6084/m9.figshare.5606983.v1
title: MA21 - Mean monthly flows

description: IHA metric describing mean monthly flow in m3 s-1. Covering 64 years (1950-2013) for German stream network (1km grid cells)
DOI: 10.6084/m9.figshare.5606965
title: MA16 - Mean monthly flows

description: IHA metric describing mean monthly flow in m3 s-1. Covering 64 years (1950-2013) for German stream network (1km grid cells)
DOI: 10.6084/m9.figshare.5606971
title: MA17 - Mean monthly flows

description: IHA metric describing mean monthly flow in m3 s-1. Covering 64 years (1950-2013) for German stream network (1km grid cells)
DOI: 10.6084/m9.figshare.5606962
title: MA15 - Mean monthly flows

description: IHA metric describing mean monthly flow in m3 s-1. Covering 64 years (1950-2013) for German stream network (1km grid cells)