cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.21227/jy12-2c41
title: Dataset for Prostate Cancer Screening Enhanced: Multi-Class Semantic Segmentation and Grading Score with the DARUN Model

description: Prostate cancer is a major global health challenge, emphasizing the need for better diagnostic methods. This study addresses this need through early detection and advanced multi-class semantic segmentation, specifically focusing on differentiating Gleason patterns 3 and 4 in prostate adenocarcinoma tissues. We utilize innovative data science techniques to potentially improve patient survival rates and address gaps in current cancer diagnosis and treatment. We introduce our publicly available dataset of 100 digitized whole-slide images, segmented into training, validation, and testing sets. To combat class imbalance, techniques like pixel expansion and computed class weights were applied. Our proposed DARUN model architecture incorporates dilated attention and residual convolutional U-Net, enhancing feature map contextual understanding. Extensive hyperparameter fine-tuning optimized training efficiency. Model performance was evaluated using ensemble methods and a Paired t-test. The DARUN models achieved an average Dice coefficient of 0.66 and an accuracy of 0.82 on unseen testing data. Additionally, we performed adenocarcinoma segmentation and grade scoring at the slide level, with pathologist-verified segmented prediction results. An ablation study confirmed the model's generalization and robustness, achieving high Jaccard and Dice coefficients on a separate testing set. Based on a limited dataset, this study suggests the potential of the proposed methodologies and DARUN models as a promising tool for early prostate cancer screening within existing clinical practice.
DOI: 10.17632/5vfz9vhm2s.1
title: Human squamous cell carcinoma stained with SignalStar mIHC technology

description: Human squamous cell carcinoma stained with SignalStar mIHC technology. Day 1 data contains Pan-Keratin in the 488 channel, CD11c in the 594 channel, Sirpa in the 647 channel and CD163 in the 750 channel. Day 2 data contains CD206 in the 488 channel, CD68 in the 594 channel, CD45 in the 647 channel and HLA-DRA in the 750 channel. A full 8 plex image can be constructed by computationally combining imaging day 1 and imaging day 2 data. These component tifs must be reconstructed into a full sized image.
DOI: 10.17632/7d3b273xh3.1
title: 21ST-CENTURY SKILLS ON TEACHERS' IMPLEMENTATION PERFORMANCE

description: This dataset was generated to understand the impact of 21st-century skills on the teaching performance of secondary school teachers in Sekondi-Takoradi, Ghana. The motivation behind creating the dataset lies in recognizing that these skills significantly affect teachers' effectiveness in integrating them into the teaching and learning process. The study's objectives were twofold: firstly, to identify specific essential skills within the broader category of 21st-century skills that play a significant role in predicting teachers' implementation performance, and secondly, to explore potential gender differences in the application of these skills among secondary school teachers.
DOI: 10.5517/ccdc.csd.cc2c40zj
title: CCDC 2178617: Experimental Crystal Structure Determination

description: Related Article: Yuxiu Zhou, Ransong Ma, Xiaoyong Li, Xiaokang Liu, Ke-Hu Wang, Junjiao Wang, Danfeng Huang, Yulai Hu|2023|J.Org.Chem.|88|17356|doi:10.1021/acs.joc.3c02174
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2clsg7
title: CCDC 2192799: Experimental Crystal Structure Determination

description: Related Article: Yannik Appiarius, Sandra Míguez-Lago, Pim Puylaert, Noah Wolf, Sourabh Kumar, Martin Molkenthin, Delia Miguel, Tim Neudecker, Michal Juríček, Araceli G. Campaña, Anne Staubitz|2023|Chemical Science|15|466|doi:10.1039/D3SC02685J
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2clsj9
title: CCDC 2192801: Experimental Crystal Structure Determination

description: Related Article: Yannik Appiarius, Sandra Míguez-Lago, Pim Puylaert, Noah Wolf, Sourabh Kumar, Martin Molkenthin, Delia Miguel, Tim Neudecker, Michal Juríček, Araceli G. Campaña, Anne Staubitz|2023|Chemical Science|15|466|doi:10.1039/D3SC02685J
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2clskb
title: CCDC 2192802: Experimental Crystal Structure Determination

description: Related Article: Yannik Appiarius, Sandra Míguez-Lago, Pim Puylaert, Noah Wolf, Sourabh Kumar, Martin Molkenthin, Delia Miguel, Tim Neudecker, Michal Juríček, Araceli G. Campaña, Anne Staubitz|2023|Chemical Science|15|466|doi:10.1039/D3SC02685J
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2clslc
title: CCDC 2192803: Experimental Crystal Structure Determination

description: Related Article: Yannik Appiarius, Sandra Míguez-Lago, Pim Puylaert, Noah Wolf, Sourabh Kumar, Martin Molkenthin, Delia Miguel, Tim Neudecker, Michal Juríček, Araceli G. Campaña, Anne Staubitz|2023|Chemical Science|15|466|doi:10.1039/D3SC02685J
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2d7rv8
title: CCDC 2212000: Experimental Crystal Structure Determination

description: Related Article: Yannik Appiarius, Sandra Míguez-Lago, Pim Puylaert, Noah Wolf, Sourabh Kumar, Martin Molkenthin, Delia Miguel, Tim Neudecker, Michal Juríček, Araceli G. Campaña, Anne Staubitz|2023|Chemical Science|15|466|doi:10.1039/D3SC02685J
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2d7rw9
title: CCDC 2212001: Experimental Crystal Structure Determination

description: Related Article: Yannik Appiarius, Sandra Míguez-Lago, Pim Puylaert, Noah Wolf, Sourabh Kumar, Martin Molkenthin, Delia Miguel, Tim Neudecker, Michal Juríček, Araceli G. Campaña, Anne Staubitz|2023|Chemical Science|15|466|doi:10.1039/D3SC02685J
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2dkfcs
title: CCDC 2221285: Experimental Crystal Structure Determination

description: Related Article: Rex S. C. Charman, Nick J. Evans, Laura E. English, Samuel E. Neale, Petra Vasko, Mary F. Mahon, David J. Liptrot|2024|Chemical Science|15|584|doi:10.1039/D3SC05862J
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2dkffv
title: CCDC 2221287: Experimental Crystal Structure Determination

description: Related Article: Rex S. C. Charman, Nick J. Evans, Laura E. English, Samuel E. Neale, Petra Vasko, Mary F. Mahon, David J. Liptrot|2024|Chemical Science|15|584|doi:10.1039/D3SC05862J
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2dqr1y
title: CCDC 2226390: Experimental Crystal Structure Determination

description: Related Article: Zhengyu Han, Biao Zhu, Yu Zang, Chaoshen Zhang, Xiu-Qin Dong, Hai Huang, Jianwei Sun|2024|Chemical Science|15|720|doi:10.1039/D3SC05014A
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2f6qp2
title: CCDC 2240794: Experimental Crystal Structure Determination

description: Related Article: Yi Zhen Tan, Xiangyang Wu, Yunpeng Lu, Shunsuke Chiba, Edwin K. L. Yeow|2023|Cat.Sci.Tech.|14|66|doi:10.1039/D3CY00942D
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2fbq0j
title: CCDC 2244617: Experimental Crystal Structure Determination

description: Related Article: Jia-Nan Chen, Zhong-Hua Pan, Qi-Hao Qiu, Cheng Wang, La-Sheng Long, Lan-Sun Zheng, Xiang-Jian Kong|2024|Chemical Science|15|511|doi:10.1039/D3SC05849B
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2fbq1k
title: CCDC 2244618: Experimental Crystal Structure Determination

description: Related Article: Jia-Nan Chen, Zhong-Hua Pan, Qi-Hao Qiu, Cheng Wang, La-Sheng Long, Lan-Sun Zheng, Xiang-Jian Kong|2024|Chemical Science|15|511|doi:10.1039/D3SC05849B
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2fd6sv
title: CCDC 2246067: Experimental Crystal Structure Determination

description: Related Article: Qiuhong Cheng, Aiyou Hao, Pengyao Xing|2024|Chemical Science|15|618|doi:10.1039/D3SC05212E
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2fd6xz
title: CCDC 2246071: Experimental Crystal Structure Determination

description: Related Article: Qiuhong Cheng, Aiyou Hao, Pengyao Xing|2024|Chemical Science|15|618|doi:10.1039/D3SC05212E
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2fd6y0
title: CCDC 2246072: Experimental Crystal Structure Determination

description: Related Article: Qiuhong Cheng, Aiyou Hao, Pengyao Xing|2024|Chemical Science|15|618|doi:10.1039/D3SC05212E
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2fd7ps
title: CCDC 2246095: Experimental Crystal Structure Determination

description: Related Article: Qiuhong Cheng, Aiyou Hao, Pengyao Xing|2024|Chemical Science|15|618|doi:10.1039/D3SC05212E
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.17632/fm2zyv224s.1
title: Positive priming effects driven by methanogenesis rather than carbon dioxide production in anoxic sediments of saline lakes

description: CO2 and CH4 production rates and their associlated isotope ratios of C13/C12; The sediment properties of the sampled saline lakes
DOI: 10.17632/nhxphwtktr.1
title: Inhibition of GCN2 Reveals Synergy with Cell-Cycle Regulation and Proteostasis

description: The integrated stress response is a signaling network comprising four branches, each sensing different cellular stressors, converging on the phosphorylation of eIF2α to downregulate global translation and initiate recovery. One of these branches includes GCN2, which senses cellular amino acid insufficiency and participates in maintaining amino acid homeostasis. Previous studies have shown that GCN2 is a viable cancer target when amino acid stress is induced by inhibiting an ad-ditional target. In this light, we screened myriad drugs for their potential to synergize with the GCN2 inhibitor TAP20. The drug sensitivity of six cancer cell lines to a panel of 25 compounds was assessed. Each compound was then combined with TAP20 at concentrations below their IC50, and the impact on cell growth was evaluated. The strongly synergistic combinations were further characterized using synergy analyses and matrix-dependent invasion assays. Inhibitors of proteostasis and the MEK–ERK pathway, as well as the pan-CDK inhibitors, flavopiridol, and seliciclib, were potently synergistic with TAP20 in two cell lines. Among their common CDK targets was CDK7, which was more selectively targeted by THZ-1 and synergized with TAP20. Moreover, these combinations were partially synergistic when assessed using matrix-dependent invasion assays. However, TAP20 alone was sufficient to restrict invasion at concentrations well below its growth-inhibitory IC50. We conclude that GCN2 inhibition can be further explored in vivo as a cancer target.
DOI: 10.17632/vkmzrmk5dt.1
title: Coprecipitation data

description: Modeling and analysis data of metal cations coprecipitated with goethite.
DOI: 10.17632/vz2ky8hjyg.1
title: Characteristics of Dissolved Organic Matter in Uranium Hosting Aquifers and Potential Molecular Transformation during Neutral In-situ Leaching

description: Physiochemical parameters, optical parameters, and molecular characteristics of DOM in U production wells (M1 and M2), monitoring wells (BM) and rock extracts derived from EEM, PARAFAC, and FT-ICR MS analysis. The average values of indices based on FT-ICR MS data here are all calculated as intensity-weighted average (e.g., H/Cwa, O/Cwa, DBEwa, NOSCwa, and (AImod)wa). The proportion of organic matter components is based on the relative abundance of molecular formulas.
DOI: 10.6084/m9.figshare.24649641
title: Data from Campbell et al 2024 Herbivore effects increase with latitude across the extent of a foundational seagrass

description: Dataset contains leaf productivity, shoot density, leaf width, temperature and light data from the Thalassia Experimental Network.
DOI: 10.6084/m9.figshare.24649641.v5
title: Data from Campbell et al 2024 Herbivore effects increase with latitude across the extent of a foundational seagrass

description: Dataset contains leaf productivity, shoot density, leaf width, temperature and light data from the Thalassia Experimental Network.
DOI: 10.6084/m9.figshare.24649641.v4
title: Data from Campbell et al 2024 Herbivore effects increase with latitude across the extent of a foundational seagrass

description: Dataset contains leaf productivity, shoot density, leaf width, temperature and light data from the Thalassia Experimental Network.
DOI: 10.6084/m9.figshare.24937131
title: R_Data_Berles et al., 2024

description: This dataset belongs to the study of Berles et al. 2024 (BMC Ecology and Evolution) with the title: "Linking morphology, performance, and habitat utilization: adaptation across biologically relevant 'levels' in tamarins".It contains raw data regarding tamarin locomotor behavior and locomotor morphology as well as R code for the reproduction of the analysis.
DOI: 10.6084/m9.figshare.24937131.v1
title: R_Data_Berles et al., 2024

description: This dataset belongs to the study of Berles et al. 2024 (BMC Ecology and Evolution) with the title: "Linking morphology, performance, and habitat utilization: adaptation across biologically relevant 'levels' in tamarins".It contains raw data regarding tamarin locomotor behavior and locomotor morphology as well as R code for the reproduction of the analysis.
DOI: 10.25550/4m-bt80
title: A PTHrP Gradient Drives Mandibular Condylar Chondrogenesis via Runx2

description: The mandibular condylar cartilage (MCC) is an essential component of the temporomandibular joint, which orchestrates the vertical growth of the mandibular ramus through endochondral ossification with distinctive modes of cell differentiation. Parathyroid hormone-related protein (PTHrP) is a master regulator of chondrogenesis; in the long bone epiphyseal growth plate, PTHrP expressed by resting zone chondrocytes promotes chondrocyte proliferation in the adjacent layer. However, how PTHrP regulates chondrogenesis in the MCC remains largely unclear. In this study, we used a Pthrp-mCherry knock-in reporter strain to map the localization of PTHrP+ cells in the MCC and define the function of PTHrP in the growing mandibular condyle. In the postnatal MCC of PthrpmCherry/+ mice, PTHrP-mCherry was specifically expressed by cells in the superficial layer immediately adjacent to RUNX2-expressing cells in the polymorphic layer. PTHrP ligands diffused across the polymorphic and chondrocyte layers where its cognate receptor PTH1R was abundantly expressed. We further analyzed the mandibular condyle of PthrpmCherry/mCherry mice lacking functional PTHrP protein (PTHrP-KO). At embryonic day (E) 18.5, the condylar process and MCC were significantly truncated in the PTHrP-KO mandible, which was associated with a significant reduction in cell proliferation across the polymorphic layer and a loss of SOX9+ cells in the chondrocyte layers. The PTHrP-KO MCC showed a transient increase in the number of Col10a1+ hypertrophic chondrocytes at E15.5, followed by a significant loss of these cells at E18.5, indicating that superficial layer-derived PTHrP prevents premature chondrocyte exhaustion in the MCC. The expression of Runx2, but not Sp7, was significantly reduced in the polymorphic layer of the PTHrP-KO MCC. Therefore, PTHrP released from cells in the superficial layer directly acts on cells in the polymorphic layer to promote proliferation of chondrocyte precursor cells and prevent their premature differentiation by maintaining Runx2 expression, revealing a unique PTHrP gradient-directed mechanism that regulates MCC chondrogenesis.
DOI: 10.34740/kaggle/dsv/7332254
title: Vietnam SARS-CoV-2 | COVID-19 Data
DOI: 10.5281/zenodo.10455742
title: Sherlock RSS-related files backup (Data, glgc2021 Part 10)
DOI: 10.5281/zenodo.10455743
title: Sherlock RSS-related files backup (Data, glgc2021 Part 10)