cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.15468/dl.ctxzve
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Odonata",
 "Geometry POLYGON ((5.9985 -1.8197, 6.1596 -1.4443, 5.9957 -1.0552, 5.6304 -0.9035, 5.2841 -1.0308, 5.1008 -1.4539, 5.2222 -1.7725, 5.639 -1.9676, 5.9985 -1.8197))",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "BasisOfRecord is one of (Specimen, Living Specimen, Observation, Human Observation, Machine Observation, Material sample, Literature Occurrence, Material citation, Occurrence evidence)"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0046421-250811113504898/datasets/export for details.
DOI: 10.3886/e237386
title: South Africa USAID Education Data

description: Seven USAID, The ELMA Foundation and J.P. Morgan funded South African project's data are included in this folder covering the period from 2012 to 2020: 1) Early Grade Reading Study (EGRS), 2) Reading Support Project (RSP), 3) South Africa Story Powered School Program, 4) Strengthening Teaching of Early Language and Literacy (STELLAR), 5) Teacher Assessment Resources for Monitoring and Improving Instruction for Foundation Phase (TARMII-FP), 6) Ukusiza, and 7) kaMhinga Literacy Project. Across these projects, the folder contains the following files and numbers of each: codebooks (30), consent (17), data files (98), instruments (63), and reports (5).
DOI: 10.3886/e237386v1
title: South Africa USAID Education Data

description: Seven USAID, The ELMA Foundation and J.P. Morgan funded South African project's data are included in this folder covering the period from 2012 to 2020: 1) Early Grade Reading Study (EGRS), 2) Reading Support Project (RSP), 3) South Africa Story Powered School Program, 4) Strengthening Teaching of Early Language and Literacy (STELLAR), 5) Teacher Assessment Resources for Monitoring and Improving Instruction for Foundation Phase (TARMII-FP), 6) Ukusiza, and 7) kaMhinga Literacy Project. Across these projects, the folder contains the following files and numbers of each: codebooks (30), consent (17), data files (98), instruments (63), and reports (5).
DOI: 10.3886/e237081
title: Democratic Republic of the Congo USAID Education Data

description: Five USAID funded Democratic Republic of the Congo project's data are included in this folder covering the period from 2011 to 2022. The projects are: 1) Accelere!, 2) Accès, Lecture, Redevabilité et Rétention! Activity 1 (A!1) Project, 3) Integrated Youth Development Activity (IYDA), 4) MECC, and 5) Opportunities for Equitable Access (OPEQ). Across these projects, the folder contains the following files and numbers of each: codebooks (37), consent (13), data files (21), instruments (21), and reports (9).
DOI: 10.3886/e237081v1
title: Democratic Republic of the Congo USAID Education Data

description: Five USAID funded Democratic Republic of the Congo project's data are included in this folder covering the period from 2011 to 2022. The projects are: 1) Accelere!, 2) Accès, Lecture, Redevabilité et Rétention! Activity 1 (A!1) Project, 3) Integrated Youth Development Activity (IYDA), 4) MECC, and 5) Opportunities for Equitable Access (OPEQ). Across these projects, the folder contains the following files and numbers of each: codebooks (37), consent (13), data files (21), instruments (21), and reports (9).
DOI: 10.15468/dl.w5bvce
title: Occurrence Download

description: A dataset containing 185 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Paracheirodon axelrodi)",
 "BasisOfRecord is one of (Specimen, Literature Occurrence, Human Observation, Observation)",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "Year is greater than or equal to 1991",
 "Year is less than or equal to 2025"
 ]
}

 The dataset includes 185 records from 19 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0046424-250811113504898/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.322eev
title: Occurrence Download

description: A dataset containing 1560 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Hemiptelea davidii"
 ]
}

 The dataset includes 1560 records from 95 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0046422-250811113504898/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.dm7xvz
title: Occurrence Download

description: A dataset containing 50205 species occurrences available in GBIF matching the query:
{
 "and" : [
 "HasCoordinate is true",
 "TaxonKey is Spiranthes spiralis"
 ]
}

 The dataset includes 50205 records from 575 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0046324-250811113504898/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.v5y78n
title: Occurrence Download

description: A dataset containing 37 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Odonata",
 "Geometry POLYGON ((6.524 -0.514, 7.0065 -0.2456, 7.2624 0.2943, 7.123 0.7051, 6.6607 0.9135, 6.1391 0.6726, 5.9617 0.2289, 6.1206 -0.3209, 6.524 -0.514))",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "BasisOfRecord is one of (Specimen, Living Specimen, Observation, Human Observation, Machine Observation, Material sample, Literature Occurrence, Material citation, Occurrence evidence)"
 ]
}

 The dataset includes 37 records from 2 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0046423-250811113504898/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.6084/m9.figshare.29987777
title: Insights into cannabinoid-HSA interactions: spectroscopic analysis and molecular docking for binding site characterization

description: Cannabinoids are increasingly recognized for their therapeutic potential, yet their pharmacokinetics remain poorly understood due to their high hydrophobicity and complex interactions with plasma proteins. Human serum albumin (HSA), the principal drug carrier in blood, critically influences the distribution, bioavailability, and efficacy of lipophilic compounds. In this study, we comprehensively investigated the binding interactions between HSA and six major cannabinoids (THC, CBD, CBC, CBG, THCV, and CBDV) using fluorescence spectroscopy, synchronous fluorescence scanning (SFS), circular dichroism (CD) spectroscopy, and molecular docking simulations. Fluorescence quenching analysis revealed a static quenching mechanism, supported by quenching rate constants (<i>K</i><sub>b</sub>) exceeding diffusion limits. Temperature-dependent studies and van’t Hoff analysis indicated that the interactions were driven primarily by hydrophobic forces, as evidenced by positive entropy and enthalpy changes. CD spectral analysis showed that most cannabinoids induced minimal or stabilizing effects on HSA’s α-helical structure, with the exception of CBDV and CBG, which caused more pronounced, concentration-dependent secondary structure changes. Molecular docking localized the binding sites predominantly within Sudlow’s sites I, involving key hydrophobic residues such as Ile, Leu, Val and Ala. Together, these findings provide new molecular insights into the transport properties of cannabinoids and highlight the role of albumin in modulating their pharmacokinetic profiles, offering valuable guidance for therapeutic drug design and delivery strategies.
DOI: 10.6084/m9.figshare.29987777.v1
title: Insights into cannabinoid-HSA interactions: spectroscopic analysis and molecular docking for binding site characterization

description: Cannabinoids are increasingly recognized for their therapeutic potential, yet their pharmacokinetics remain poorly understood due to their high hydrophobicity and complex interactions with plasma proteins. Human serum albumin (HSA), the principal drug carrier in blood, critically influences the distribution, bioavailability, and efficacy of lipophilic compounds. In this study, we comprehensively investigated the binding interactions between HSA and six major cannabinoids (THC, CBD, CBC, CBG, THCV, and CBDV) using fluorescence spectroscopy, synchronous fluorescence scanning (SFS), circular dichroism (CD) spectroscopy, and molecular docking simulations. Fluorescence quenching analysis revealed a static quenching mechanism, supported by quenching rate constants (<i>K</i><sub>b</sub>) exceeding diffusion limits. Temperature-dependent studies and van’t Hoff analysis indicated that the interactions were driven primarily by hydrophobic forces, as evidenced by positive entropy and enthalpy changes. CD spectral analysis showed that most cannabinoids induced minimal or stabilizing effects on HSA’s α-helical structure, with the exception of CBDV and CBG, which caused more pronounced, concentration-dependent secondary structure changes. Molecular docking localized the binding sites predominantly within Sudlow’s sites I, involving key hydrophobic residues such as Ile, Leu, Val and Ala. Together, these findings provide new molecular insights into the transport properties of cannabinoids and highlight the role of albumin in modulating their pharmacokinetic profiles, offering valuable guidance for therapeutic drug design and delivery strategies.
DOI: 10.6084/m9.figshare.27678630
title: A novel reinforcement learning-based method for structure optimization

description: With the rapid development of deep learning technology, Reinforcement Learning (RL) has garnered considerable acclaim within the realm of structural optimization owing to its excellent exploration mechanism. However, the widespread application of RL in this field is limited owing to the excessive number of iterations required to converge and the expensive computational cost it brings. To address these challenges, this article presents a novel RL framework for structural optimization, combining Monte Carlo tree search with the proximal policy optimization method, called LMPOM. The key contributions of LMPOM encompass: (1) an enhanced Monte Carlo tree search strategy for partitioning the hybrid design space; (2) a strategy for adaptively updating surrogate models to reduce simulation costs; and (3) the introduction of a novel termination condition for the RL algorithms. Through tests on three benchmark problems, compared with previous RL algorithms, LMPOM consistently shows fewer iterations and better optimization results.
DOI: 10.6084/m9.figshare.27678630.v1
title: A novel reinforcement learning-based method for structure optimization

description: With the rapid development of deep learning technology, Reinforcement Learning (RL) has garnered considerable acclaim within the realm of structural optimization owing to its excellent exploration mechanism. However, the widespread application of RL in this field is limited owing to the excessive number of iterations required to converge and the expensive computational cost it brings. To address these challenges, this article presents a novel RL framework for structural optimization, combining Monte Carlo tree search with the proximal policy optimization method, called LMPOM. The key contributions of LMPOM encompass: (1) an enhanced Monte Carlo tree search strategy for partitioning the hybrid design space; (2) a strategy for adaptively updating surrogate models to reduce simulation costs; and (3) the introduction of a novel termination condition for the RL algorithms. Through tests on three benchmark problems, compared with previous RL algorithms, LMPOM consistently shows fewer iterations and better optimization results.
DOI: 10.15468/dl.kubu82
title: Occurrence Download

description: A dataset containing 673 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Leptuca thayeri"
 ]
}

 The dataset includes 673 records from 32 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0046425-250811113504898/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.nkeacj
title: Occurrence Download

description: A dataset containing 40 records in GBIF matching the query:

SELECT
countrycode,
 GBIF_ISEA3HCode(
 8, 
 decimalLatitude,
 decimalLongitude,
 COALESCE(coordinateUncertaintyInMeters, 1000) 
 ) AS geogrid_id,
 COUNT(DISTINCT speciesKey) AS unique_species_count
FROM occurrence
WHERE countrycode IN ('BW','GB','CO','AU','GT','FR')
AND distancefromcentroidinmeters &gt;= 2000
AND class = 'Insecta'
AND hasCoordinate = TRUE
AND occurrenceStatus = 'PRESENT'
AND NOT ARRAY_CONTAINS(issue, 'ZERO_COORDINATE')
AND NOT ARRAY_CONTAINS(issue, 'COORDINATE_OUT_OF_RANGE')
AND NOT ARRAY_CONTAINS(issue, 'COORDINATE_INVALID')
AND NOT ARRAY_CONTAINS(issue, 'COUNTRY_COORDINATE_MISMATCH')
GROUP BY countrycode, geogrid_id;


 The dataset's 40 records were derived from 258 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0046409-250811113504898/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.tmatjn
title: Occurrence Download

description: A dataset containing 2988 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Cecropia pachystachya)",
 "HasCoordinate is true",
 "HasGeospatialIssue is false"
 ]
}

 The dataset includes 2988 records from 172 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0046426-250811113504898/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.z99tuq
title: Occurrence Download

description: A dataset containing 163 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Parietaria debilis",
 "Country is Argentina",
 "HasCoordinate is true"
 ]
}

 The dataset includes 163 records from 12 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0046427-250811113504898/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.6bjv42
title: Occurrence Download

description: A dataset containing 3 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Peckoltia pankimpuju)",
 "BasisOfRecord is one of (Specimen, Literature Occurrence, Human Observation, Observation)",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "Year is greater than or equal to 1991",
 "Year is less than or equal to 2025"
 ]
}

 The dataset includes 3 records from 2 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0046429-250811113504898/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.mrce5p
title: Occurrence Download

description: A dataset containing 105 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Odonata",
 "Geometry POLYGON ((10.0615 -3.4463, 10.1382 -3.5292, 10.1382 2.0599, 9.2753 2.0599, 9.2723 2.0399, 8.8555 1.2955, 8.8103 -0.1351, 8.354 -0.2687, 8.2157 -0.7924, 8.7426 -1.8029, 8.6574 -2.0749, 8.8035 -2.4281, 9.149 -2.574, 10.0615 -3.4463))",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "BasisOfRecord is one of (Specimen, Living Specimen, Observation, Human Observation, Machine Observation, Material sample, Literature Occurrence, Material citation, Occurrence evidence)"
 ]
}

 The dataset includes 105 records from 6 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0046428-250811113504898/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.6084/m9.figshare.29339123
title: hfCas12Max-Mediated Targeted Integration at Accessible Chromatin Regions with a Novel UCOE Enhances Stable Recombinant Lactoferrin Expression

description: Stable transgene expression in livestock mammary glands is crucial for recombinant protein production but is often disrupted by transgene silencing and random genomic integration. To overcome these issues, we used ATAC-seq to analyze chromatin accessibility in goat mammary epithelial cells (GMECs), identifying 15 highly accessible genomic regions. Three of these regions were confirmed to support stable transgene expression through dual-luciferase reporter assays and flow cytometry. Notably, we identified a new goat-derived ubiquitous chromatin opening element (UCOE) in the SF3B1-COQ10B intergenic region, with a high GC content (65%) and CpG island enrichment. This UCOE improved CRISPR/hfCas12Max-mediated integration of large DNA fragments and maintained high-level expression of human lactoferrin (hLTF) in GMECs. Subsequently, we precisely integrated the UCOE-hLTF cassette into the ROSA26 safe harbor locus using hfCas12Max and successfully generated transgenic goats via somatic cell nuclear transfer, without detectable off-target effects. Our comprehensive pipeline, combining chromatin accessibility profiling, UCOE discovery, and precision editing, highlights the role of CpG island-containing UCOEs in preventing transgene silencing. This provides vital tools for improved recombinant protein production and aids in breeding dairy goats for lactoferrin-rich milk, while advancing understanding of chromatin-regulatory element-transgene interactions in molecular breeding.
DOI: 10.6084/m9.figshare.29339123.v3
title: hfCas12Max-Mediated Targeted Integration at Accessible Chromatin Regions with a Novel UCOE Enhances Stable Recombinant Lactoferrin Expression

description: Stable transgene expression in livestock mammary glands is crucial for recombinant protein production but is often disrupted by transgene silencing and random genomic integration. To overcome these issues, we used ATAC-seq to analyze chromatin accessibility in goat mammary epithelial cells (GMECs), identifying 15 highly accessible genomic regions. Three of these regions were confirmed to support stable transgene expression through dual-luciferase reporter assays and flow cytometry. Notably, we identified a new goat-derived ubiquitous chromatin opening element (UCOE) in the SF3B1-COQ10B intergenic region, with a high GC content (65%) and CpG island enrichment. This UCOE improved CRISPR/hfCas12Max-mediated integration of large DNA fragments and maintained high-level expression of human lactoferrin (hLTF) in GMECs. Subsequently, we precisely integrated the UCOE-hLTF cassette into the ROSA26 safe harbor locus using hfCas12Max and successfully generated transgenic goats via somatic cell nuclear transfer, without detectable off-target effects. Our comprehensive pipeline, combining chromatin accessibility profiling, UCOE discovery, and precision editing, highlights the role of CpG island-containing UCOEs in preventing transgene silencing. This provides vital tools for improved recombinant protein production and aids in breeding dairy goats for lactoferrin-rich milk, while advancing understanding of chromatin-regulatory element-transgene interactions in molecular breeding.
DOI: 10.6084/m9.figshare.29339123.v2
title: hfCas12Max-Mediated Targeted Integration at Accessible Chromatin Regions with a Novel UCOE Enhances Stable Recombinant Lactoferrin Expression

description: Transgenic production of recombinant proteins in livestock milk shows commercial potential, but stable transgene expression is often hindered by transgene silencing and poor integration site selection. This study used ATAC-seq to analyze chromatin accessibility in goat mammary epithelial cells, identifying 15 highly accessible sites. Validation through dual luciferase reporter assays and flow cytometry confirmed stable transgene expression at three of these sites. Additionally, we discovered a novel goat-derived ubiquitous chromatin-opening element (UCOE) in the SF3B1-COQ10B intergenic region, characterized by high GC content (65%) and CpG islands. This UCOE improved CRISPR/hfCas12Max-mediated transgene integration efficiency and stabilized human lactoferrin (<i>hLTF</i>) expression in GMECs. Notably, hfCas12Max was more effective than CRISPR/Cas9 for integrating large DNA fragments at specific loci. We used hfCas12Max to integrate the UCOE-hLTF cassette into the <i>ROSA26 </i>locus, creating a transgenic goat kid via somatic cell nuclear transfer without off-target effects. Our research establishes a chromatin accessibility-guided CRISPR/hfCas12Max gene-editing pipeline, highlights the pivotal role of UCOE elements containing CpG islands in overcoming transgene silencing, and provides a translational framework for high-performance mammary bioreactors. These findings enhance our understanding of the interplay between chromatin architecture, regulatory elements, and transgene expression in livestock, offering resources for precision breeding of lactoferrin-enriched dairy goats.
DOI: 10.15468/dl.3za5se
title: Occurrence Download

description: A dataset containing 1194 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Lonicera ferdinandi"
 ]
}

 The dataset includes 1194 records from 62 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0046430-250811113504898/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.cgytsv
title: Occurrence Download

description: A dataset containing 12395392 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is Ecuador",
 "OccurrenceStatus is Present"
 ]
}

 The dataset includes 12395392 records from 2164 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0046376-250811113504898/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.gxbszz
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Winteria Brauer, 1901",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "BasisOfRecord is one of (Specimen, Living Specimen, Observation, Human Observation, Machine Observation, Material sample, Literature Occurrence, Material citation, Occurrence evidence)",
 "Geometry POLYGON ((44.9096 1.1987,44.9648 1.2321,44.9648 1.8496,35.9648 1.8496,35.9648 -7.1504,40.3029 -7.1504,40.4263 -6.8134,40.0733 -6.4249,39.9535 -5.9102,40.3587 -5.2718,40.3515 -4.7573,40.0702 -4.4392,40.3811 -3.7186,40.7402 -3.0348,41.8195 -2.1723,43.8399 0.2902,44.9096 1.1987))"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0008948-250525065834625/datasets/export for details.
DOI: 10.25574/cdc.220
title: Chandra X-ray Observatory Chandra Data Collection for request #220

description: Chandra Data Collection for request #220
description: DOI updated to include the publication's DOI on 2025-05-30-09:30:00
DOI: 10.15468/dl.raascp
title: Occurrence Download

description: A dataset containing 106 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is Brazil",
 "TaxonKey is Dalbergia elegans A.M.Carvalho"
 ]
}

 The dataset includes 106 records from 32 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0008950-250525065834625/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.7910/dvn/28913
title: Achei USA 397

description: Newspaper