cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.3489944.v1
title: Standard treatment for brain tumor patients

description: Children and adolescents with brainstem tumors have no standardized widely accepted treatment. In our hospital service, in the last 15 years, we treated 87 pediatric patients with brainstem tumors. Of those, 24 patients (28%) had focal tumors of the brainstem, which are usually benign, indolent and permit long-term survival if treated properly. In our department, 79% of these patients survived four years or more after their diagnosis, and most remain in follow-up clinic. In contrast, 63 patients (72%) were diagnosed with diffuse pontine tumors (DIPG). Among those patients, survival 2 years after diagnosis was only 6%, and no patients survived more than 4 years.(excerpt)
DOI: 10.6084/m9.figshare.3489944.v2
title: Standard treatment for brain tumor patients

description: Children and adolescents with brainstem tumors have no standardized widely accepted treatment. In our hospital service, in the last 15 years, we treated 87 pediatric patients with brainstem tumors. Of those, 24 patients (28%) had focal tumors of the brainstem, which are usually benign, indolent and permit long-term survival if treated properly. In our department, 79% of these patients survived four years or more after their diagnosis, and most remain in follow-up clinic. In contrast, 63 patients (72%) were diagnosed with diffuse pontine tumors (DIPG). Among those patients, survival 2 years after diagnosis was only 6%, and no patients survived more than 4 years.(excerpt)
DOI: 10.6084/m9.figshare.3489944.v3
title: Standard treatment for brain tumor patients

description: Children and adolescents with brainstem tumors have no standardized widely accepted treatment. In our hospital service, in the last 15 years, we treated 87 pediatric patients with brainstem tumors. Of those, 24 patients (28%) had focal tumors of the brainstem, which are usually benign, indolent and permit long-term survival if treated properly. In our department, 79% of these patients survived four years or more after their diagnosis, and most remain in follow-up clinic. In contrast, 63 patients (72%) were diagnosed with diffuse pontine tumors (DIPG). Among those patients, survival 2 years after diagnosis was only 6%, and no patients survived more than 4 years.(excerpt)
DOI: 10.6084/m9.figshare.3489941
title: Diagnostic criteria for diffuse intrinsic pontine glioma - DIPG

description: Although there are no diagnostic criteria defined in the literature, we use a definition similar to that found in the HIT-GBM-D trial protocol:<br>&gt; Diffuse intrinsic pontine glioma: center: pons, T1 tumor: hypointense, T2: hyperintense, CT: mostly hypodense, When Compared to regular pontine tissue. Diffuse tumor with margins and extension to more than half of the brainstem cross diameter. The regular pontine tissue might either Been missing in the level of the maximal tumor extension or might Have Been reduced to a small kidney, but is not simply dislocated by a single solid tumor nodule (...). This group has a tumor clinical history of less than 6 month. The diagnoses can be made radiologically without histological verification.(excerpt)<br>
DOI: 10.6084/m9.figshare.3489941.v1
title: Diagnostic criteria for DIPG

description: Although there are no diagnostic criteria defined in the literature, we use a definition similar to that found in the HIT-GBM-D trial protocol:<br>&gt; Diffuse intrinsic pontine glioma: center: pons, T1 tumor: hypointense, T2: hyperintense, CT: mostly hypodense, When Compared to regular pontine tissue. Diffuse tumor with margins and extension to more than half of the brainstem cross diameter. The regular pontine tissue might either Been missing in the level of the maximal tumor extension or might Have Been reduced to a small kidney, but is not simply dislocated by a single solid tumor nodule (...). This group has a tumor clinical history of less than 6 month. The diagnoses can be made radiologically without histological verification.(excerpt)<br>
DOI: 10.6084/m9.figshare.3489941.v3
title: Diagnostic criteria for diffuse intrinsic pontine glioma - DIPG

description: Although there are no diagnostic criteria defined in the literature, we use a definition similar to that found in the HIT-GBM-D trial protocol:<br>&gt; Diffuse intrinsic pontine glioma: center: pons, T1 tumor: hypointense, T2: hyperintense, CT: mostly hypodense, When Compared to regular pontine tissue. Diffuse tumor with margins and extension to more than half of the brainstem cross diameter. The regular pontine tissue might either Been missing in the level of the maximal tumor extension or might Have Been reduced to a small kidney, but is not simply dislocated by a single solid tumor nodule (...). This group has a tumor clinical history of less than 6 month. The diagnoses can be made radiologically without histological verification.(excerpt)<br>
DOI: 10.6084/m9.figshare.3489941.v2
title: Diagnostic criteria for DIPG

description: Although there are no diagnostic criteria defined in the literature, we use a definition similar to that found in the HIT-GBM-D trial protocol:<br>&gt; Diffuse intrinsic pontine glioma: center: pons, T1 tumor: hypointense, T2: hyperintense, CT: mostly hypodense, When Compared to regular pontine tissue. Diffuse tumor with margins and extension to more than half of the brainstem cross diameter. The regular pontine tissue might either Been missing in the level of the maximal tumor extension or might Have Been reduced to a small kidney, but is not simply dislocated by a single solid tumor nodule (...). This group has a tumor clinical history of less than 6 month. The diagnoses can be made radiologically without histological verification.(excerpt)<br>
DOI: 10.6084/m9.figshare.3489938
title: Our twitter - Project VALKYRIE

description: Integration between Jekyll and Twitter through jekyll-twitter-plugin created by Robert Murray. Unfortunately, Github does not permit this plugin, but this was bypassed serving the page locally and retrieving the html files - _voilà_!(excerpt)<br>
DOI: 10.6084/m9.figshare.3489938.v2
title: Our twitter - Project VALKYRIE

description: Integration between Jekyll and Twitter through jekyll-twitter-plugin created by Robert Murray. Unfortunately, Github does not permit this plugin, but this was bypassed serving the page locally and retrieving the html files - _voilà_!(excerpt)<br>
DOI: 10.6084/m9.figshare.3489938.v1
title: Our twitter

description: Integration between Jekyll and Twitter through jekyll-twitter-plugin created by Robert Murray. Unfortunately, Github does not permit this plugin, but this was bypassed serving the page locally and retrieving the html files - _voilà_!(excerpt)<br>
DOI: 10.6084/m9.figshare.3489932
title: Analysis of medical images with an open tool

description: Medical images are usually provided in digital format through CD or DVD recorded by the radiology clinic. These images are stored in a standard format, called [DICOM][dicom] (*Digital Imaging and Communications in Medicine*). The availability of images in digital format allows handling and sharing with greater flexibility. In our trial, we are performing the review of images digitally acquired (when available) in **anonymised** form, ie, without any information that can directly or indirectly identify patients. To do this, we will use the medical image sharing service [DICOM Library][dicom-library]. This service, created by Softneta with funding from the European Union, retrieves DICOM files, anonymizing them automatically in the browser side before uploading and allows one to share medical images without identification of patients, professionals and health services.(excerpt)
DOI: 10.6084/m9.figshare.3489932.v1
title: Analysis of images

description: Medical images are usually provided in digital format through CD or DVD recorded by the radiology clinic. These images are stored in a standard format, called [DICOM][dicom] (*Digital Imaging and Communications in Medicine*). The availability of images in digital format allows handling and sharing with greater flexibility. In our trial, we are performing the review of images digitally acquired (when available) in **anonymised** form, ie, without any information that can directly or indirectly identify patients. To do this, we will use the medical image sharing service [DICOM Library][dicom-library]. This service, created by Softneta with funding from the European Union, retrieves DICOM files, anonymizing them automatically in the browser side before uploading and allows one to share medical images without identification of patients, professionals and health services.(excerpt)
DOI: 10.6084/m9.figshare.3489917
title: A little about Project VALKYRIE's rational

description: Diffuse intrinsic pontine glioma, [DIPG][dipg-poster], is a tumor almost exclusively found in children and adolescents. It is largely responsible for most of the deaths related to brain tumors in this age group. Nearly 20% of all brain tumors in patients under 18 years are DIPG. This makes it one of the most common malignant brain tumors in young people. The average age of patients is 7 years, there is no difference between sexes or races. It is rare to a patient to have a history of more than 6 months of symptons before diagnosis. Initial signs are facial paralysis, deviation of the eyes, neck pain (torticollis). In a matter of weeks, the intensity and number of symptoms progress and the patient begins to have difficulty swallowing and speaking, as well as gait impairment and paralysis.(excerpt)
DOI: 10.6084/m9.figshare.3489917.v2
title: A little about Project VALKYRIE's rational

description: Diffuse intrinsic pontine glioma, [DIPG][dipg-poster], is a tumor almost exclusively found in children and adolescents. It is largely responsible for most of the deaths related to brain tumors in this age group. Nearly 20% of all brain tumors in patients under 18 years are DIPG. This makes it one of the most common malignant brain tumors in young people. The average age of patients is 7 years, there is no difference between sexes or races. It is rare to a patient to have a history of more than 6 months of symptons before diagnosis. Initial signs are facial paralysis, deviation of the eyes, neck pain (torticollis). In a matter of weeks, the intensity and number of symptoms progress and the patient begins to have difficulty swallowing and speaking, as well as gait impairment and paralysis.(excerpt)
DOI: 10.6084/m9.figshare.3489917.v1
title: A little about the trial's rational

description: Diffuse intrinsic pontine glioma, [DIPG][dipg-poster], is a tumor almost exclusively found in children and adolescents. It is largely responsible for most of the deaths related to brain tumors in this age group. Nearly 20% of all brain tumors in patients under 18 years are DIPG. This makes it one of the most common malignant brain tumors in young people. The average age of patients is 7 years, there is no difference between sexes or races. It is rare to a patient to have a history of more than 6 months of symptons before diagnosis. Initial signs are facial paralysis, deviation of the eyes, neck pain (torticollis). In a matter of weeks, the intensity and number of symptoms progress and the patient begins to have difficulty swallowing and speaking, as well as gait impairment and paralysis.(excerpt)
DOI: 10.6084/m9.figshare.3487805
title: PLOS ONE: Body Weight Can Change How Your Emotions Are Perceived

description: Study: Body Weight Can Change How Your Emotions Are PerceivedAuthors: Yujung Oh, Norah C. Hass,and Seung-Lark LimPLOS ONE <br>This file includes demographic, perceptual decision, and reaction time data. Each row represents a single subject. Columns are defined as:<br>Task :1 (Experiment 1), 2 (Experiment 2)ID :subject ID Sex :1 (male), 2 (female) age :ageethnicity :1 (Caucasian), 2 (Hispanic), 3 (African American), 4 (Asian), 5 (Other) N_000 : decision for 0% emotion normal weight face N_020 : decision for 20% emotion normal weight face N_040 : decision for 40% emotion normal weight face N_060 : decision for 60% emotion normal weight face N_080 : decision for 80% emotion normal weight face N_100 : decision for 100% emotion normal weight face <br>O_000 : decision for 0% emotion overweight face O_020 : decision for 0% emotion overweight face O_040 : decision for 0% emotion overweight face O_060 : decision for 0% emotion overweight face O_080 : decision for 0% emotion overweight face O_100 : decision for 0% emotion overweight face <br>Rmax_N :estimated Rmax parameter of normal weight face Rmax_O :estimated Rmax parameter of overweight face n_N :estimated n parameter of normal weight face n_O :estimated n parameter of overweight face c50_N :estimated c50 parameter of normal weight face c50_O :estimated c50 parameter of overweight face M_N :estimated M parameter of normal weight face M_O :estimated M parameter of overweight face <br>Rt_N_000 : reaction time (ms) for 0% emotion normal weight face Rt_N_020 : reaction time (ms) for 20% emotion normal weight face Rt_N_040 : reaction time (ms) for 40% emotion normal weight face Rt_N_060 : reaction time (ms) for 60% emotion normal weight face Rt_N_080 : reaction time (ms) for 80% emotion normal weight face Rt_N_100 : reaction time (ms) for 100% emotion normal weight face <br>Rt_O_000 : reaction time (ms) for 0% emotion overweight face Rt_O_020 : reaction time (ms) for 0% emotion overweight face Rt_O_040 : reaction time (ms) for 0% emotion overweight face Rt_O_060 : reaction time (ms) for 0% emotion overweight face Rt_O_080 : reaction time (ms) for 0% emotion overweight face Rt_O_100 : reaction time (ms) for 0% emotion overweight face <br>BMI : Body Mass IndexAFAD : Anti-fat Attitudes “Dislike”AFAF : Anti-fat Attitudes “Fear”AFAW : Anti-fat Attitudes “Willpower”<br><br><br>_________________________________________________________________________________________________ Correspondence to Seung-Lark Lim, Ph.D. Assistant Professor, Department of PsychologyUniversity of Missouri - Kansas City 5030 Cherry StKansas City, MO 64110Phone: 816-235-1067E-mail: limse@umkc.edu
DOI: 10.6084/m9.figshare.3487799
title: Water and tissue equivalence properties of biological materials for photons, electrons, protons and alpha particles in the energy region 10 keV–1 GeV: a comparative study

description: <b>Purpose:</b> To compare some biological materials in respect to the water and tissue equivalence properties for photon, electron, proton and alpha particle interactions as means of the effective atomic number (<i>Z<sub>eff</sub></i>) and electron density (<i>N<sub>e</sub></i>). <b>Methods:</b> A Z-wise interpolation procedure has been adopted for calculation of <i>Z<sub>eff</sub></i> using the mass attenuation coefficients for photons and the mass stopping powers for charged particles. <b>Results:</b> At relatively low energies (100 keV–3 MeV), <i>Z<sub>eff</sub></i> and <i>N<sub>e</sub></i> for photons and electrons were found to be constant while they vary much more for protons and alpha particles. In contrast, <i>Z<sub>eff</sub></i> and <i>N<sub>e</sub></i> for protons and alpha particles were found to be constant after 3 MeV whereas for photons and electrons they were found to increase with the increasing energy. Also, muscle eq. liquid (with sucrose) have <i>Z<sub>eff</sub></i> and <i>N<sub>e</sub> </i>values close to the Muscle Skeletal (ICRP) and Muscle Striated (ICRU) within low relative differences below 9%. Muscle eq. liquid (without sucrose) have <i>Z<sub>eff</sub></i> and <i>N<sub>e</sub></i> values close to the Muscle Skeletal (ICRP) and Muscle Striated (ICRU) with difference below 10%. <b>Conclusions:</b> The reported data should be useful in determining best water as well as tissue equivalent materials for photon, electron, proton and alpha particle interactions.
DOI: 10.6084/m9.figshare.3487799.v1
title: Water and tissue equivalence properties of biological materials for photons, electrons, protons and alpha particles in the energy region 10 keV–1 GeV: a comparative study

description: <b>Purpose:</b> To compare some biological materials in respect to the water and tissue equivalence properties for photon, electron, proton and alpha particle interactions as means of the effective atomic number (<i>Z<sub>eff</sub></i>) and electron density (<i>N<sub>e</sub></i>). <b>Methods:</b> A Z-wise interpolation procedure has been adopted for calculation of <i>Z<sub>eff</sub></i> using the mass attenuation coefficients for photons and the mass stopping powers for charged particles. <b>Results:</b> At relatively low energies (100 keV–3 MeV), <i>Z<sub>eff</sub></i> and <i>N<sub>e</sub></i> for photons and electrons were found to be constant while they vary much more for protons and alpha particles. In contrast, <i>Z<sub>eff</sub></i> and <i>N<sub>e</sub></i> for protons and alpha particles were found to be constant after 3 MeV whereas for photons and electrons they were found to increase with the increasing energy. Also, muscle eq. liquid (with sucrose) have <i>Z<sub>eff</sub></i> and <i>N<sub>e</sub> </i>values close to the Muscle Skeletal (ICRP) and Muscle Striated (ICRU) within low relative differences below 9%. Muscle eq. liquid (without sucrose) have <i>Z<sub>eff</sub></i> and <i>N<sub>e</sub></i> values close to the Muscle Skeletal (ICRP) and Muscle Striated (ICRU) with difference below 10%. <b>Conclusions:</b> The reported data should be useful in determining best water as well as tissue equivalent materials for photon, electron, proton and alpha particle interactions.
DOI: 10.6084/m9.figshare.3487784
title: MedDRA® automated term groupings using OntoADR: evaluation with upper gastrointestinal bleedings

description: <b>Objective</b>: To propose a method to build customized sets of MedDRA terms for the description of a medical condition. We illustrate this method with upper gastrointestinal bleedings (UGIB). <b>Research design and methods</b>: We created a broad list of MedDRA terms related to UGIB and defined a gold standard with the help of experts. MedDRA terms were formally described in a semantic resource named OntoADR. We report the use of two semantic queries that automatically select candidate terms for UGIB. Query 1 is a combination of two SNOMED CT concepts describing both morphology ‘Hemorrhage’ and finding site ‘Upper digestive tract structure’. Query 2 complements Query 1 by taking into account MedDRA terms associated to SNOMED CT concepts describing clinical manifestations ‘Melena’ or ‘Hematemesis’. <b>Results</b>: We compared terms in queries and our gold standard achieving a recall of 71.0% and a precision of 81.4% for query 1 (F1 score 0.76); and a recall of 96.7% and a precision of 77.0% for query 2 (F1 score 0.86). <b>Conclusions</b>: Our results demonstrate the feasibility of applying knowledge engineering techniques for building customized sets of MedDRA terms. Additional work is necessary to improve precision and recall, and confirm the interest of the proposed strategy.
DOI: 10.6084/m9.figshare.3487784.v1
title: MedDRA® automated term groupings using OntoADR: evaluation with upper gastrointestinal bleedings

description: <b>Objective</b>: To propose a method to build customized sets of MedDRA terms for the description of a medical condition. We illustrate this method with upper gastrointestinal bleedings (UGIB). <b>Research design and methods</b>: We created a broad list of MedDRA terms related to UGIB and defined a gold standard with the help of experts. MedDRA terms were formally described in a semantic resource named OntoADR. We report the use of two semantic queries that automatically select candidate terms for UGIB. Query 1 is a combination of two SNOMED CT concepts describing both morphology ‘Hemorrhage’ and finding site ‘Upper digestive tract structure’. Query 2 complements Query 1 by taking into account MedDRA terms associated to SNOMED CT concepts describing clinical manifestations ‘Melena’ or ‘Hematemesis’. <b>Results</b>: We compared terms in queries and our gold standard achieving a recall of 71.0% and a precision of 81.4% for query 1 (F1 score 0.76); and a recall of 96.7% and a precision of 77.0% for query 2 (F1 score 0.86). <b>Conclusions</b>: Our results demonstrate the feasibility of applying knowledge engineering techniques for building customized sets of MedDRA terms. Additional work is necessary to improve precision and recall, and confirm the interest of the proposed strategy.
DOI: 10.6084/m9.figshare.3487739.v1
title: mTVM vs Hyst TOT final v1.xlsx

description: Data set for the project : A novel method for the surgical correction of anterior compartment pelvic organ prolapse Q-II concurrent with genuine stress urinary incontinence: a transvaginal four-arm mesh fixed to the mid-urethra<b></b><b></b>
DOI: 10.6084/m9.figshare.3487733
title: Structural analysis and molecular docking of trypanocidal aryloxy-quinones in trypanothione and glutathione reductases: a comparison with biochemical data

description: A set of aryloxy-quinones, previously synthesized and evaluated against <i>Trypanosoma cruzi</i> epimastigotes cultures, were found more potent and selective than nifurtimox. One of the possible mechanisms of the trypanocidal activity of these quinones could be inhibition of trypanothione reductase (TR). Considering that glutathione reductase (GR) is the equivalent of TR in humans, biochemical, kinetic, and molecular docking studies in TR and GR were envisaged and compared with the trypanocidal and cytotoxic data of a set of aryloxy-quinones. Biochemical assays indicated that three naphthoquinones (<b>Nq-h</b>, <b>Nq-g</b>, and <b>Nq-d</b>) selectively inhibit TR and the TR kinetic analyses indicated that <b>Nq-h</b> inhibit TR in a noncompetitive mechanism. Molecular dockings were performed in TR and GR in the following three putative binding sites: the catalytic site, the dimer interface, and the nicotinamide adenine dinucleotide phosphate-binding site. In TR and GR, the aryloxy-quinones were found to exhibit high affinity for a site near it cognate-binding site in a place in which the noncompetitive kinetics could be justified. Taking as examples the three compounds with TR specificity (TRS) (<b>Nq-h</b>, <b>Nq-g</b>, and <b>Nq-d</b>), the presence of a network of contacts with the quinonic ring sustained by the triad of Lys62, Met400′, Ser464′ residues, seems to contribute hardly to the TRS. Compound <b>Nq-b</b>, a naphthoquinone with nitrophenoxy substituent, proved to be the best scaffold for the design of trypanocidal compounds with low toxicity. However, the compound displayed only a poor and non-selective effect toward TR indicating that TR inhibition is not the main reason for the antiparasitic activity of the aryloxy-quinones.