DOI: 10.5061/dryad.n9c1rb0
title: Data from: Theta-modulation drives the emergence of connectivity patterns underlying replay in a network model of place cells

description: Place cells of the rodent hippocampus fire action potentials when the
 animal traverses a particular spatial location in any environment.
 Therefore for any given trajectory one observes a repeatable sequence of
 place cell activations. When the animal is quiescent or sleeping, one can
 observe similar sequences of activation known as replay, which underlie
 the process of memory consolidation. However, it remains unclear how
 replay is generated. Here we show how a temporally asymmetric plasticity
 rule during spatial exploration gives rise to spontaneous replay in a
 model network by shaping the recurrent connectivity to reflect the
 topology of the learned environment. Crucially, the rate of this encoding
 is strongly modulated by ongoing rhythms. Oscillations in the theta range
 optimize learning by generating repeated pre-post pairings on a time-scale
 commensurate with the window for plasticity, while lower and higher
 frequencies generate learning rates which are lower by orders of
 magnitude.
description: Rat A991 on novel square
 track w muscimolMatlab file with
 multi-unit, lfp and animal position. 35 min exploration of novel square
 track, medial septum inactivated by muscimol. From Pastalkova lab at
 Janelia Research Campus, data collected by Yingxue
 Wang.Yingxue Wang -
 A991-20140826-02_BehavElectrDataLFP_muscimol.matRat A991 on square track post-muscimolMatlab file with multi-unit, lfp and animal position. 35 min exploration of square track after animal recovered from medial septum inactivated by muscimol. From Pastalkova lab at Janelia Research Campus, data collected by Yingxue Wang.A991-20140826-04_BehavElectrDataLFP.matRat A992 on novel square track w muscimolMatlab file with multi-unit, lfp and animal position. 35 min exploration of novel square track, medial septum inactivated by muscimol. From Pastalkova lab at Janelia Research Campus, data collected by Yingxue Wang.Yingxue Wang - A992-20140824-01_BehavElectrDataLFP_muscimol.matRat A992 on square track post-muscimolMatlab file with multi-unit, lfp and animal position. 35 min exploration of novel square track after recovery from medial septum inactivated by muscimol. From Pastalkova lab at Janelia Research Campus, data collected by Yingxue Wang.A992-20140824-03_BehavElectrDataLFP.matRat A991 on novel hexagonal trackMatlab file with multi-unit, lfp and animal position. 35 min exploration of novel hexagonal track: session 1. From Pastalkova lab at Janelia Research Campus, data collected by Yingxue Wang.A991-20140830-01_BehavElectrDataLFP.matRat A991 on novel hexagonal track (2nd session)Matlab file with multi-unit, lfp and animal position. 35 min exploration of novel hexagonal track: session 2. From Pastalkova lab at Janelia Research Campus, data collected by Yingxue Wang.Yingxue Wang - A991-20140830-03_BehavElectrDataLFP.matRat A991 on novel hexagonal track (3rd session)Matlab file with multi-unit, lfp and animal position. 35 min exploration of novel hexagonal track: session 3. From Pastalkova lab at Janelia Research Campus, data collected by Yingxue Wang.A991-20140830-05_BehavElectrDataLFP.matRat A992 on novel hexagonal trackMatlab file with multi-unit, lfp and animal position. 35 min exploration of novel hexagonal track: session 1. From Pastalkova lab at Janelia Research Campus, data collected by Yingxue Wang.A992-20140831-01_BehavElectrDataLFP.matRat A992 on novel hexagonal track (2nd session)Matlab file with multi-unit, lfp and animal position. 35 min exploration of novel hexagonal track: session 2. From Pastalkova lab at Janelia Research Campus, data collected by Yingxue Wang.Yingxue Wang - A992-20140831-03_BehavElectrDataLFP.matRat A992 on novel hexagonal track (3rd session)Matlab file with multi-unit, lfp and animal position. 35 min exploration of novel hexagonal track: session 3. From Pastalkova lab at Janelia Research Campus, data collected by Yingxue Wang.A992-20140831-05_BehavElectrDataLFP.mat