cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.5966344
title: Geostatistical modelling of the spatial life history of post-larval deepwater hake <i>Merluccius paradoxus</i> in the Benguela Current Large Marine Ecosystem

description: Optimal and sustainable management of fish resources cannot be ensured without a thorough understanding of the migration patterns and population (demographic stock) structure. Recent studies suggest that these aspects of the economically and ecologically important deepwater hake <i>Merluccius paradoxus</i> are not reflected in the current assessment and management practices for the Benguela Current Large Marine Ecosystem. In this study, we compiled data from multiple demersal trawl surveys from the entire distribution area and applied state-of-the-art geostatistical population modelling (GeoPop) to estimate growth rate, mortality, and spatial and temporal distribution patterns of <i>M. paradoxus</i>. The data and the model enabled us to follow temporal and spatial changes in the distribution and infer movements from the recruitment/nursery areas, through the juvenile phase and the adults’ migration to the spawning areas outside/upstream of the nursery areas. The results indicated one primary recruitment/nursery area on the west coast of South Africa and a secondary less-productive recruitment/nursery area on the south coast near Port Elizabeth. Juveniles initially migrated away from the main recruitment area, followed by natal homing by larger individuals. This pattern was highly consistent through the time-series of the study. This perception of a, primarily, panmictic population that performs transboundary migrations between Namibia and South Africa corresponds largely to the hypothesis and data plots given in recent studies. We recommend that fisheries assessment, advice and management take into consideration these aspects of the distribution and population (stock) structure of <i>M. paradoxus</i>.
DOI: 10.6084/m9.figshare.5966344.v1
title: Geostatistical modelling of the spatial life history of post-larval deepwater hake <i>Merluccius paradoxus</i> in the Benguela Current Large Marine Ecosystem

description: Optimal and sustainable management of fish resources cannot be ensured without a thorough understanding of the migration patterns and population (demographic stock) structure. Recent studies suggest that these aspects of the economically and ecologically important deepwater hake <i>Merluccius paradoxus</i> are not reflected in the current assessment and management practices for the Benguela Current Large Marine Ecosystem. In this study, we compiled data from multiple demersal trawl surveys from the entire distribution area and applied state-of-the-art geostatistical population modelling (GeoPop) to estimate growth rate, mortality, and spatial and temporal distribution patterns of <i>M. paradoxus</i>. The data and the model enabled us to follow temporal and spatial changes in the distribution and infer movements from the recruitment/nursery areas, through the juvenile phase and the adults’ migration to the spawning areas outside/upstream of the nursery areas. The results indicated one primary recruitment/nursery area on the west coast of South Africa and a secondary less-productive recruitment/nursery area on the south coast near Port Elizabeth. Juveniles initially migrated away from the main recruitment area, followed by natal homing by larger individuals. This pattern was highly consistent through the time-series of the study. This perception of a, primarily, panmictic population that performs transboundary migrations between Namibia and South Africa corresponds largely to the hypothesis and data plots given in recent studies. We recommend that fisheries assessment, advice and management take into consideration these aspects of the distribution and population (stock) structure of <i>M. paradoxus</i>.
DOI: 10.6084/m9.figshare.5966332
title: Raw data figure 3.xlsx

description: Raw data from Figure 3 of publication:<br>doi:10.1371/journal.pone.0194561<br>
DOI: 10.6084/m9.figshare.5966332.v1
title: Raw data figure 3.xlsx

description: Raw data from Figure 3 of publication:<br>doi:10.1371/journal.pone.0194561<br>
DOI: 10.6084/m9.figshare.5966320
title: Numerical time bins from The evolutionary history of polycotylid plesiosaurians

description: Numerical ages, two binning methods (wide and per stage/substage)
DOI: 10.6084/m9.figshare.5966320.v1
title: Numerical time bins from The evolutionary history of polycotylid plesiosaurians

description: Numerical ages, two binning methods (wide and per stage/substage)
DOI: 10.6084/m9.figshare.5966314
title: R script from The evolutionary history of polycotylid plesiosaurians

description: R script
DOI: 10.6084/m9.figshare.5966314.v1
title: R script from The evolutionary history of polycotylid plesiosaurians

description: R script
DOI: 10.6084/m9.figshare.5966311
title: Pruned Phylogenetic dataset from The evolutionary history of polycotylid plesiosaurians

description: Nexus file with most parsimonious trees included
DOI: 10.6084/m9.figshare.5966311.v1
title: Pruned Phylogenetic dataset from The evolutionary history of polycotylid plesiosaurians

description: Nexus file with most parsimonious trees included
DOI: 10.6084/m9.figshare.5966308
title: Full Phylogenetic dataset from The evolutionary history of polycotylid plesiosaurians

description: Nexus file with most parsimonious trees included
DOI: 10.6084/m9.figshare.5966308.v1
title: Full Phylogenetic dataset from The evolutionary history of polycotylid plesiosaurians

description: Nexus file with most parsimonious trees included
DOI: 10.6084/m9.figshare.5966302
title: Taxon ages for full phylogenetic dataset from The evolutionary history of polycotylid plesiosaurians

description: Numerical; per stage or substage
DOI: 10.6084/m9.figshare.5966302.v1
title: Taxon ages for full phylogenetic dataset from The evolutionary history of polycotylid plesiosaurians

description: Numerical; per stage or substage
DOI: 10.6084/m9.figshare.5966299
title: Bauplan/morphological data from The evolutionary history of polycotylid plesiosaurians

description: Ready-to-use text file
DOI: 10.6084/m9.figshare.5966299.v1
title: Bauplan/morphological data from The evolutionary history of polycotylid plesiosaurians

description: Ready-to-use text file
DOI: 10.6084/m9.figshare.5966281
title: Raw data figure 2.xlsx

description: Raw data from Figure 2<br>doi:10.1371/journal.pone.0194561<br>
DOI: 10.6084/m9.figshare.5966224
title: Evidence of Promoting Prevention and the Early Detection of Breast Cancer among Women, a Hospital based model in LMICs Data extraction forms (Responses).xlsx

description: This is a systematic review. Ethical approval is not applicable. The study protocol was first developed and was registered in the PROSPERO international prospective register of systematic reviews (Chien, Khan, & Siassakos, 2012) (CRD42017077818). Employing standard systematic review strategies (Higgins & Green, 2011; Shamseer et al., 2015), we searched for all study types that focused on hospital/clinic based BC awareness and early detection services for healthy women in LMICs. The criteria for selecting the studies for review as well as the awareness and screening of interest (BCE, BSE and CBE) are shown in table 1.Table 1: A PICOS framework for determining the eligibility of the Studies for the Primary Research QuestionCriteria DeterminantsP- Population The population of this study will be healthy women with no evidence of malignancy accessing a BCE or screening intervention I- Intervention Patient-focused BCE and raising awareness over risk factors, early BC signs and symptoms, BC screening and/or detection among womenC- Comparison None<br>O- Outcomes • Increased knowledge on BC• Practice BSE• Access CBE services• Early detection of BC• Reduced incidence of BC S- Study Setting LMICs; within a health care facility (hospital/clinic) <br>The quality of included stuides were assessed using Effective Public Health Practice Project (EPHPP) Quality Assessment Tool recommended by Cochrane for quantitative studies (Effective Public Health Practice Project, 2010)<br>PRISMA diagram was used to summerized the selection procedure of the studies
DOI: 10.6084/m9.figshare.5966224.v1
title: Evidence of Promoting Prevention and the Early Detection of Breast Cancer among Women, a Hospital based model in LMICs Data extraction forms (Responses).xlsx

description: This is a systematic review. Ethical approval is not applicable. The study protocol was first developed and was registered in the PROSPERO international prospective register of systematic reviews (Chien, Khan, & Siassakos, 2012) (CRD42017077818). Employing standard systematic review strategies (Higgins & Green, 2011; Shamseer et al., 2015), we searched for all study types that focused on hospital/clinic based BC awareness and early detection services for healthy women in LMICs. The criteria for selecting the studies for review as well as the awareness and screening of interest (BCE, BSE and CBE) are shown in table 1.Table 1: A PICOS framework for determining the eligibility of the Studies for the Primary Research QuestionCriteria DeterminantsP- Population The population of this study will be healthy women with no evidence of malignancy accessing a BCE or screening intervention I- Intervention Patient-focused BCE and raising awareness over risk factors, early BC signs and symptoms, BC screening and/or detection among womenC- Comparison None<br>O- Outcomes • Increased knowledge on BC• Practice BSE• Access CBE services• Early detection of BC• Reduced incidence of BC S- Study Setting LMICs; within a health care facility (hospital/clinic) <br>The quality of included stuides were assessed using Effective Public Health Practice Project (EPHPP) Quality Assessment Tool recommended by Cochrane for quantitative studies (Effective Public Health Practice Project, 2010)<br>PRISMA diagram was used to summerized the selection procedure of the studies
DOI: 10.6084/m9.figshare.5966224.v3
title: Evidence of Promoting Prevention and the Early Detection of Breast Cancer among Women, a Hospital based model in LMICs Data extraction forms (Responses).xlsx

description: This is a systematic review. Ethical approval is not applicable. The study protocol was first developed and was registered in the PROSPERO international prospective register of systematic reviews (Chien, Khan, & Siassakos, 2012) (CRD42017077818). Employing standard systematic review strategies (Higgins & Green, 2011; Shamseer et al., 2015), we searched for all study types that focused on hospital/clinic based BC awareness and early detection services for healthy women in LMICs. The criteria for selecting the studies for review as well as the awareness and screening of interest (BCE, BSE and CBE) are shown in table 1.Table 1: A PICOS framework for determining the eligibility of the Studies for the Primary Research QuestionCriteria DeterminantsP- Population The population of this study will be healthy women with no evidence of malignancy accessing a BCE or screening intervention I- Intervention Patient-focused BCE and raising awareness over risk factors, early BC signs and symptoms, BC screening and/or detection among womenC- Comparison None<br>O- Outcomes • Increased knowledge on BC• Practice BSE• Access CBE services• Early detection of BC• Reduced incidence of BC S- Study Setting LMICs; within a health care facility (hospital/clinic) <br>The quality of included stuides were assessed using Effective Public Health Practice Project (EPHPP) Quality Assessment Tool recommended by Cochrane for quantitative studies (Effective Public Health Practice Project, 2010)<br>PRISMA diagram was used to summerized the selection procedure of the studies
DOI: 10.6084/m9.figshare.5966224.v2
title: Evidence of Promoting Prevention and the Early Detection of Breast Cancer among Women, a Hospital based model in LMICs Data extraction forms (Responses).xlsx

description: This is a systematic review. Ethical approval is not applicable. The study protocol was first developed and was registered in the PROSPERO international prospective register of systematic reviews (Chien, Khan, & Siassakos, 2012) (CRD42017077818). Employing standard systematic review strategies (Higgins & Green, 2011; Shamseer et al., 2015), we searched for all study types that focused on hospital/clinic based BC awareness and early detection services for healthy women in LMICs. The criteria for selecting the studies for review as well as the awareness and screening of interest (BCE, BSE and CBE) are shown in table 1.Table 1: A PICOS framework for determining the eligibility of the Studies for the Primary Research QuestionCriteria DeterminantsP- Population The population of this study will be healthy women with no evidence of malignancy accessing a BCE or screening intervention I- Intervention Patient-focused BCE and raising awareness over risk factors, early BC signs and symptoms, BC screening and/or detection among womenC- Comparison None<br>O- Outcomes • Increased knowledge on BC• Practice BSE• Access CBE services• Early detection of BC• Reduced incidence of BC S- Study Setting LMICs; within a health care facility (hospital/clinic) <br>The quality of included stuides were assessed using Effective Public Health Practice Project (EPHPP) Quality Assessment Tool recommended by Cochrane for quantitative studies (Effective Public Health Practice Project, 2010)<br>PRISMA diagram was used to summerized the selection procedure of the studies
DOI: 10.6084/m9.figshare.5966218
title: Raw data figure 1.xlsx

description: Raw data of Figure 1 in<br>doi:10.1371/journal.pone.0194561<br><br>
DOI: 10.6084/m9.figshare.5966218.v1
title: Raw data figure 1.xlsx

description: Raw data of Figure 1 in<br>doi:10.1371/journal.pone.0194561<br><br>
DOI: 10.6084/m9.figshare.5966215.v1
title: Original Data and Brief Introduction

description: Original Data and Tables for the Figures proposed in paper
DOI: 10.6084/m9.figshare.5966098
title: River Wye Geometric Data

description: Geometric data for the River Wye in Derbyshire, used in a dissertation to look at natural flood management
DOI: 10.6084/m9.figshare.5966098.v1
title: River Wye Geometric Data

description: Geometric data for the River Wye in Derbyshire, used in a dissertation to look at natural flood management
DOI: 10.6084/m9.figshare.5966056
title: Timelapse videos of Fig.1D and 2A

description: <b>FoxO3a nuclear-cytoplasmic pulsing dynamics in 184A1 mammary epithelial cell line following growth-factor treatment with varying ERK/AKT activation loads. </b><br><i>Assay Description</i>The nuclear-cytoplasmic pulsing behavior of a FoxO3a fluorescent reporter (FoxO3aN400-Venus) expressed in the 184A1 mammary epithelial cell line was assessed at the single-cell level using live imaging of cells that were untreated or treated with one of six growth factors in the absence or presence of an AKT or MEK inhibitor.Complete raw images can be found in the HMS OMERO link below.<b><br></b><b>Refer to platemap.pdf for the dosing and types of ligands, and inhibitors at each row,column combination.</b><br>
DOI: 10.6084/m9.figshare.5966056.v1
title: Timelapse videos of Fig.1D and 2A

description: <b>FoxO3a nuclear-cytoplasmic pulsing dynamics in 184A1 mammary epithelial cell line following growth-factor treatment with varying ERK/AKT activation loads. </b><br><i>Assay Description</i>The nuclear-cytoplasmic pulsing behavior of a FoxO3a fluorescent reporter (FoxO3aN400-Venus) expressed in the 184A1 mammary epithelial cell line was assessed at the single-cell level using live imaging of cells that were untreated or treated with one of six growth factors in the absence or presence of an AKT or MEK inhibitor.Complete raw images can be found in the HMS OMERO link below.<b><br></b><b>Refer to platemap.pdf for the dosing and types of ligands, and inhibitors at each row,column combination.</b><br>
DOI: 10.6084/m9.figshare.5966047
title: Table2.xlsx

description: Table2
DOI: 10.6084/m9.figshare.5966047.v1
title: Table2.xlsx

description: Table2
DOI: 10.6084/m9.figshare.5966044
title: Table1.xlsx

description: Table1
DOI: 10.6084/m9.figshare.5966044.v1
title: Table1.xlsx

description: Table1
DOI: 10.6084/m9.figshare.5966023
title: Exposure to human influence - ArcGIS toolbox and raster for Slovakia

description: Fileset contains an ArcGIS tool that can be used to calculate an "Exposure to human influense" raster. "Exposure to human influence" is a new spatial variable for the land use and land cover change modelling, approximating the intensity of human influence on the landscape. The “exposure” simulates the dilution of human activity from settlements (source points with information about population size or other human activity quantification) to landscape, based on the accessibility. Exposure to a settlement is directly proportional to its population size and inversely proportional to the cost distance from the settlement. Cost distance uses the sine of the slope angle as a cost raster to simulate a barrier effect of the terrain. Overall exposure to human influence summates exposure to all individual settlements in a region. The resultant raster field created for Slovakia is supplemented.<br>
DOI: 10.6084/m9.figshare.5966023.v1
title: Exposure to human influence - ArcGIS toolbox and raster for Slovakia

description: Fileset contains an ArcGIS tool that can be used to calculate an "Exposure to human influense" raster. "Exposure to human influence" is a new spatial variable for the land use and land cover change modelling, approximating the intensity of human influence on the landscape. The “exposure” simulates the dilution of human activity from settlements (source points with information about population size or other human activity quantification) to landscape, based on the accessibility. Exposure to a settlement is directly proportional to its population size and inversely proportional to the cost distance from the settlement. Cost distance uses the sine of the slope angle as a cost raster to simulate a barrier effect of the terrain. Overall exposure to human influence summates exposure to all individual settlements in a region. The resultant raster field created for Slovakia is supplemented.<br>
DOI: 10.6084/m9.figshare.5965927
title: Test-retest stability

description: These data contain the distance between a first and second simulated measure of cancellation performance based on constant input parameters. The model used to generate the data is a simple probabilistic step function.<br>
DOI: 10.6084/m9.figshare.5965927.v1
title: Test-retest stability

description: These data contain the distance between a first and second simulated measure of cancellation performance based on constant input parameters. The model used to generate the data is a simple probabilistic step function.<br>
DOI: 10.6084/m9.figshare.5965921
title: Classification results

description: These datasets contain the results of classifying simulated observations of cancellation performance according to cut-off scores generated through three different methods. The measures of classification accuracy are the: d-prime, a measure of bias (C), the false alarms and errors of false direction (classifying a left spatial asymmetry as a right spatial asymmetry and vice versa).<br>
DOI: 10.6084/m9.figshare.5965921.v1
title: Classification results

description: These datasets contain the results of classifying simulated observations of cancellation performance according to cut-off scores generated through three different methods. The measures of classification accuracy are the: d-prime, a measure of bias (C), the false alarms and errors of false direction (classifying a left spatial asymmetry as a right spatial asymmetry and vice versa).<br>
DOI: 10.6084/m9.figshare.5965915
title: Estimated cut-off scores

description: This dataset contains files with estimated cut-off scores on the basis of simulated null distributions of two measures of cancellation performance. The cut-off scores were generated through 3 different methods.<br>
DOI: 10.6084/m9.figshare.5965915.v1
title: Estimated cut-off scores

description: This dataset contains files with estimated cut-off scores on the basis of simulated null distributions of two measures of cancellation performance. The cut-off scores were generated through 3 different methods.<br>
DOI: 10.6084/m9.figshare.5965912
title: An evidence-based review of pregabalin for the treatment of fibromyalgia

description: <b>Objectives:</b> Pregabalin, an α2-δ agonist, is approved for the treatment of fibromyalgia (FM) in the United States, Japan, and 37 other countries. The purpose of this article was to provide an in-depth, evidence-based summary of pregabalin for FM as demonstrated in randomized, placebo-controlled clinical studies, including open-label extensions, meta-analyses, combination studies and post-hoc analyses of clinical study data. <b>Methods:</b> PubMed was searched using the term “pregabalin AND fibromyalgia” and the Cochrane Library with the term “pregabalin”. Both searches were conducted on 2 March 2017 with no other date limits set. <b>Results:</b> Eleven randomized, double-blind, placebo-controlled clinical studies were identified including parallel group, two-way crossover and randomized withdrawal designs. One was a neuroimaging study. Five open-label extensions were also identified. Evidence of efficacy was demonstrated across the studies identified with significant and clinically relevant improvements in pain, sleep quality and patient status. The safety and tolerability profile of pregabalin is consistent across all the studies identified, including in adolescents, with dizziness and somnolence the most common adverse events reported. These efficacy and safety data are supported by meta-analyses (13 studies). Pregabalin in combination with other pharmacotherapies (7 studies) is also efficacious. Post-hoc analyses have demonstrated the onset of pregabalin efficacy as early as 1–2 days after starting treatment, examined the effect of pregabalin on other aspects of sleep beyond quality, and shown it is effective irrespective of the presence of a wide variety of patient demographic and clinical characteristics. <b>Conclusions:</b> Pregabalin is a treatment option for FM; its clinical utility has been comprehensively demonstrated.