cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.23626680
title: Elucidation of furanone as ergosterol pathway inhibitor in <i>Cryptococcus neoformans</i>

description: In the era of antiretroviral therapy, the prevalence of Cryptococcal infection among HIV patients in developed countries has decreased considerably. However, <i>C. neoformans</i> ranks top among the critical priority pathogen that affects a wide range of immunocompromised individuals. The threat of <i>C. neoformans</i> is because of its incredibly multifaceted intracellular survival capabilities. Cell membrane sterols especially ergosterol and enzymes of its biosynthetic pathway are considered fascinating drug targets because of their structural stability. In this study, the ergosterol biosynthetic enzymes were modeled and docked with furanone derivatives. Among the tested ligands Compound <b>6</b> has shown a potential interaction with Lanosterol 14 α-demethylase. This best-docked protein-ligand complex was taken further to molecular dynamics simulation. In addition, Compound <b>6</b> was synthesized and an <i>in vitro</i> study was conducted to quantify the ergosterol in Compound <b>6</b> treated cells. Altogether the computational and <i>in vitro</i> study demonstrates that Compound <b>6</b> has anticryptococcal activity by targeting the biosynthetic pathway of ergosterol. Communicated by Ramaswamy H. Sarma
DOI: 10.6084/m9.figshare.23626680.v1
title: Elucidation of furanone as ergosterol pathway inhibitor in <i>Cryptococcus neoformans</i>

description: In the era of antiretroviral therapy, the prevalence of Cryptococcal infection among HIV patients in developed countries has decreased considerably. However, <i>C. neoformans</i> ranks top among the critical priority pathogen that affects a wide range of immunocompromised individuals. The threat of <i>C. neoformans</i> is because of its incredibly multifaceted intracellular survival capabilities. Cell membrane sterols especially ergosterol and enzymes of its biosynthetic pathway are considered fascinating drug targets because of their structural stability. In this study, the ergosterol biosynthetic enzymes were modeled and docked with furanone derivatives. Among the tested ligands Compound <b>6</b> has shown a potential interaction with Lanosterol 14 α-demethylase. This best-docked protein-ligand complex was taken further to molecular dynamics simulation. In addition, Compound <b>6</b> was synthesized and an <i>in vitro</i> study was conducted to quantify the ergosterol in Compound <b>6</b> treated cells. Altogether the computational and <i>in vitro</i> study demonstrates that Compound <b>6</b> has anticryptococcal activity by targeting the biosynthetic pathway of ergosterol. Communicated by Ramaswamy H. Sarma
DOI: 10.6084/m9.figshare.23652330
title: Search for novel <i>Plasmodium falciparum Pf</i>ATP4 inhibitors from the MMV Pandemic Response Box through a virtual screening approach

description: Owing to its life cycle involving multiple hosts and species-specific biological complexities, a vaccine against <i>Plasmodium</i>, the causative agent of <i>Malaria</i> remains elusive. This makes chemotherapy the only viable means to address the clinical manifestations and spread of this deadly disease. However, rapid surge in antimalarial resistance poses significant challenges to our efforts to eliminate <i>Malaria</i> since the best drug available to-date; Artemisinin and its combinations are also rapidly losing efficacy. Sodium ATPase (<i>Pf</i>ATP4) of <i>Plasmodium</i> has been recently explored as a suitable target for new antimalarials such as <i>Cipargamin</i>. Prior studies showed that multiple compounds from the Medicines for Malaria Venture (MMV) chemical libraries were efficient <i>Pf</i>ATP4 inhibitors. In this context, we undertook a structure- based virtual screening approach combined to Molecular Dynamic (MD) simulations to evaluate whether new molecules with binding affinity towards <i>Pf</i>ATP4 could be identified from the Pandemic Response Box (PRB), a 400-compound library of small molecules launched in 2019 by MMV. Our analysis identified new molecules from the PRB library that showed affinity for distinct binding sites including the previously known G358 site, several of which are clinically used anti-bacterial (MMV1634383, MMV1634402), antiviral (MMV010036, MMV394033) or antifungal (MMV1634494) agents. Therefore, this study highlights the possibility of exploiting PRB molecules against <i>Malaria</i> through abrogation of <i>Pf</i>ATP4 activity. Communicated by Ramaswamy H. Sarma
DOI: 10.6084/m9.figshare.23652330.v1
title: Search for novel <i>Plasmodium falciparum Pf</i>ATP4 inhibitors from the MMV Pandemic Response Box through a virtual screening approach

description: Owing to its life cycle involving multiple hosts and species-specific biological complexities, a vaccine against <i>Plasmodium</i>, the causative agent of <i>Malaria</i> remains elusive. This makes chemotherapy the only viable means to address the clinical manifestations and spread of this deadly disease. However, rapid surge in antimalarial resistance poses significant challenges to our efforts to eliminate <i>Malaria</i> since the best drug available to-date; Artemisinin and its combinations are also rapidly losing efficacy. Sodium ATPase (<i>Pf</i>ATP4) of <i>Plasmodium</i> has been recently explored as a suitable target for new antimalarials such as <i>Cipargamin</i>. Prior studies showed that multiple compounds from the Medicines for Malaria Venture (MMV) chemical libraries were efficient <i>Pf</i>ATP4 inhibitors. In this context, we undertook a structure- based virtual screening approach combined to Molecular Dynamic (MD) simulations to evaluate whether new molecules with binding affinity towards <i>Pf</i>ATP4 could be identified from the Pandemic Response Box (PRB), a 400-compound library of small molecules launched in 2019 by MMV. Our analysis identified new molecules from the PRB library that showed affinity for distinct binding sites including the previously known G358 site, several of which are clinically used anti-bacterial (MMV1634383, MMV1634402), antiviral (MMV010036, MMV394033) or antifungal (MMV1634494) agents. Therefore, this study highlights the possibility of exploiting PRB molecules against <i>Malaria</i> through abrogation of <i>Pf</i>ATP4 activity. Communicated by Ramaswamy H. Sarma
DOI: 10.15468/dl.crkvgg
title: Occurrence Download

description: A dataset listing the 99222 species recorded in GBIF matching the query:
{
 "and" : [
 "Country is Austria",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present"
 ]
}

 The dataset's 99222 records were derived from 1549 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0000073-240626123714530/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.25549/rbm-c58-1078
title: Cat trotting and galloping

description: Cat trotting and galloping. This is plate 718, captioned "'Cat trotting, changing to gallop" from Eadweard Muybridge. Animal locomotion: an electro-photographic investigation of consecutive phases of animal movements. 1872-1885 / published under the auspices of the University of Pennsylvania. Plates. The plates printed by the Photo-Gravure Company. Philadelphia, 1887.
DOI: 10.25549/rbm-c58-5287
title: Dog Ike galloping

description: Dog Ike galloping This is plate 708, captioned "'Ike' galloping" from Eadweard Muybridge. Animal locomotion: an electro-photographic investigation of consecutive phases of animal movements. 1872-1885 / published under the auspices of the University of Pennsylvania. Plates. The plates printed by the Photo-Gravure Company. Philadelphia, 1887.
DOI: 10.25549/rbm-c58-5359
title: Dog Maggie galloping

description: Dog Maggie galloping. This is plate 710, captioned "'Maggie' galloping" from Eadweard Muybridge. Animal locomotion: an electro-photographic investigation of consecutive phases of animal movements. 1872-1885 / published under the auspices of the University of Pennsylvania. Plates. The plates printed by the Photo-Gravure Company. Philadelphia, 1887.
DOI: 10.15468/dl.pahj7f
title: Occurrence Download

description: A dataset containing 4 species occurrences available in GBIF matching the query:
{
 "and" : [
 "GadmGid is CHN.29_1",
 "OccurrenceStatus is Present",
 "TaxonKey is Macaca assamensis"
 ]
}

 The dataset includes 4 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0029542-260208012135463/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.25549/rbm-c58-5361
title: Dog Maggie galloping

description: Dog Maggie galloping. This is plate 710, captioned "'Maggie' galloping" from Eadweard Muybridge. Animal locomotion: an electro-photographic investigation of consecutive phases of animal movements. 1872-1885 / published under the auspices of the University of Pennsylvania. Plates. The plates printed by the Photo-Gravure Company. Philadelphia, 1887.
DOI: 10.25549/rbm-c58-5313
title: Dogs Ike and Maggie racing

description: Dogs Ike and Maggie racing. This is plate 711, captioned "'Ike' and 'Maggie' racing" from Eadweard Muybridge. Animal locomotion: an electro-photographic investigation of consecutive phases of animal movements. 1872-1885 / published under the auspices of the University of Pennsylvania. Plates. The plates printed by the Photo-Gravure Company. Philadelphia, 1887.
DOI: 10.5281/zenodo.18129205
title: Linked collectors and determiners for: Molecular Phylogeny and Taxonomic Revision of the Genus Diastatea (Campanulaceae: Lobelioideae).

description: Natural history specimen data linked to collectors and determiners held within, "Molecular Phylogeny and Taxonomic Revision of the Genus Diastatea (Campanulaceae: Lobelioideae)". Claims or attributions were made on Bionomia by volunteer Scribes, https://bionomia.net/dataset/4b2a84bd-4c4f-44f7-9bda-e3e52539c1c0 using specimen data from the dataset aggregated by the Global Biodiversity Information Facility, https://gbif.org/dataset/4b2a84bd-4c4f-44f7-9bda-e3e52539c1c0. Formatted as a Frictionless Data package.
DOI: 10.5281/zenodo.18699087
title: Linked collectors and determiners for: Molecular Phylogeny and Taxonomic Revision of the Genus Diastatea (Campanulaceae: Lobelioideae).

description: Natural history specimen data linked to collectors and determiners held within, "Molecular Phylogeny and Taxonomic Revision of the Genus Diastatea (Campanulaceae: Lobelioideae)". Claims or attributions were made on Bionomia by volunteer Scribes, https://bionomia.net/dataset/4b2a84bd-4c4f-44f7-9bda-e3e52539c1c0 using specimen data from the dataset aggregated by the Global Biodiversity Information Facility, https://gbif.org/dataset/4b2a84bd-4c4f-44f7-9bda-e3e52539c1c0. Formatted as a Frictionless Data package.
DOI: 10.5281/zenodo.18129209
title: Linked collectors and determiners for: Orthomnion javense (Mniaceae, Bryophyta), new to India and Nepal.

description: Natural history specimen data linked to collectors and determiners held within, "Orthomnion javense (Mniaceae, Bryophyta), new to India and Nepal". Claims or attributions were made on Bionomia by volunteer Scribes, https://bionomia.net/dataset/5263548c-8671-402e-8c2c-c17c7fa51dfc using specimen data from the dataset aggregated by the Global Biodiversity Information Facility, https://gbif.org/dataset/5263548c-8671-402e-8c2c-c17c7fa51dfc. Formatted as a Frictionless Data package.
DOI: 10.5281/zenodo.18699088
title: Linked collectors and determiners for: Orthomnion javense (Mniaceae, Bryophyta), new to India and Nepal.

description: Natural history specimen data linked to collectors and determiners held within, "Orthomnion javense (Mniaceae, Bryophyta), new to India and Nepal". Claims or attributions were made on Bionomia by volunteer Scribes, https://bionomia.net/dataset/5263548c-8671-402e-8c2c-c17c7fa51dfc using specimen data from the dataset aggregated by the Global Biodiversity Information Facility, https://gbif.org/dataset/5263548c-8671-402e-8c2c-c17c7fa51dfc. Formatted as a Frictionless Data package.
DOI: 10.25549/rbm-c58-5328
title: Dogs Ike and Maggie racing

description: Dogs Ike and Maggie racing. This is plate 711, captioned "'Ike' and 'Maggie' racing" from Eadweard Muybridge. Animal locomotion: an electro-photographic investigation of consecutive phases of animal movements. 1872-1885 / published under the auspices of the University of Pennsylvania. Plates. The plates printed by the Photo-Gravure Company. Philadelphia, 1887.
DOI: 10.25549/rbm-c58-3051
title: Horse Daisy jumping a hurdle, saddled with a rider

description: Horse Daisy jumping a hurdle, saddled with a rider. This is plate 639, captioned "'Daisy' jumping a hurdle, saddled" from Eadweard Muybridge. Animal locomotion: an electro-photographic investigation of consecutive phases of animal movements. 1872-1885 / published under the auspices of the University of Pennsylvania. Plates. The plates printed by the Photo-Gravure Company. Philadelphia, 1887.
DOI: 10.25549/rbm-c58-3054
title: Horse Daisy jumping a hurdle, saddled with a rider

description: Horse Daisy jumping a hurdle, saddled with a rider. This is plate 639, captioned "'Daisy' jumping a hurdle, saddled" from Eadweard Muybridge. Animal locomotion: an electro-photographic investigation of consecutive phases of animal movements. 1872-1885 / published under the auspices of the University of Pennsylvania. Plates. The plates printed by the Photo-Gravure Company. Philadelphia, 1887.
DOI: 10.5281/zenodo.18699092
title: Linked collectors and determiners for: NEON Biorepository Benthic Macroinvertebrate Collection (Fluid Preserved Oligochaetes).

description: Natural history specimen data linked to collectors and determiners held within, "NEON Biorepository Benthic Macroinvertebrate Collection (Fluid Preserved Oligochaetes)". Claims or attributions were made on Bionomia by volunteer Scribes, https://bionomia.net/dataset/6789ac99-6532-4f2b-85bb-cb1e5add7a95 using specimen data from the dataset aggregated by the Global Biodiversity Information Facility, https://gbif.org/dataset/6789ac99-6532-4f2b-85bb-cb1e5add7a95. Formatted as a Frictionless Data package.
DOI: 10.5281/zenodo.18699093
title: Linked collectors and determiners for: NEON Biorepository Benthic Macroinvertebrate Collection (Fluid Preserved Oligochaetes).

description: Natural history specimen data linked to collectors and determiners held within, "NEON Biorepository Benthic Macroinvertebrate Collection (Fluid Preserved Oligochaetes)". Claims or attributions were made on Bionomia by volunteer Scribes, https://bionomia.net/dataset/6789ac99-6532-4f2b-85bb-cb1e5add7a95 using specimen data from the dataset aggregated by the Global Biodiversity Information Facility, https://gbif.org/dataset/6789ac99-6532-4f2b-85bb-cb1e5add7a95. Formatted as a Frictionless Data package.
DOI: 10.25549/rbm-c58-3039
title: Horse Daisy jumping a hurdle, saddled with a rider

description: Horse Daisy jumping a hurdle, saddled with a rider. This is plate 639, captioned "'Daisy' jumping a hurdle, saddled" from Eadweard Muybridge. Animal locomotion: an electro-photographic investigation of consecutive phases of animal movements. 1872-1885 / published under the auspices of the University of Pennsylvania. Plates. The plates printed by the Photo-Gravure Company. Philadelphia, 1887.
DOI: 10.25549/rbm-c58-3061
title: Horse Pandora jumping hurdle, saddled with a rider, knocking over the hurdle and landing

description: Horse Pandora jumping hurdle, saddled with a rider, knocking over the hurdle and landing. This is plate 641, captioned "'Pandora' jumping a hurdle, saddled, knocking over the hurdle and landing" from Eadweard Muybridge. Animal locomotion: an electro-photographic investigation of consecutive phases of animal movements. 1872-1885 / published under the auspices of the University of Pennsylvania. Plates. The plates printed by the Photo-Gravure Company. Philadelphia, 1887.
DOI: 10.5281/zenodo.18699091
title: Linked collectors and determiners for: Leonardoxa africana (Leguminosae: Caesalpinioideae): a complex of mostly allopatric subspecies.

description: Natural history specimen data linked to collectors and determiners held within, "Leonardoxa africana (Leguminosae: Caesalpinioideae): a complex of mostly allopatric subspecies". Claims or attributions were made on Bionomia by volunteer Scribes, https://bionomia.net/dataset/595c018d-d2da-41c4-b45a-72a5e98efc5a using specimen data from the dataset aggregated by the Global Biodiversity Information Facility, https://gbif.org/dataset/595c018d-d2da-41c4-b45a-72a5e98efc5a. Formatted as a Frictionless Data package.
DOI: 10.5281/zenodo.18129211
title: Linked collectors and determiners for: Leonardoxa africana (Leguminosae: Caesalpinioideae): a complex of mostly allopatric subspecies.

description: Natural history specimen data linked to collectors and determiners held within, "Leonardoxa africana (Leguminosae: Caesalpinioideae): a complex of mostly allopatric subspecies". Claims or attributions were made on Bionomia by volunteer Scribes, https://bionomia.net/dataset/595c018d-d2da-41c4-b45a-72a5e98efc5a using specimen data from the dataset aggregated by the Global Biodiversity Information Facility, https://gbif.org/dataset/595c018d-d2da-41c4-b45a-72a5e98efc5a. Formatted as a Frictionless Data package.
DOI: 10.25549/rbm-c58-3064
title: Horse Pandora jumping hurdle, saddled with a rider, knocking over the hurdle and landing

description: Horse Pandora jumping hurdle, saddled with a rider, knocking over the hurdle and landing. This is plate 641, captioned "'Pandora' jumping a hurdle, saddled, knocking over the hurdle and landing" from Eadweard Muybridge. Animal locomotion: an electro-photographic investigation of consecutive phases of animal movements. 1872-1885 / published under the auspices of the University of Pennsylvania. Plates. The plates printed by the Photo-Gravure Company. Philadelphia, 1887.
DOI: 10.25549/rbm-c58-5268
title: Dog Dread galloping

description: Dog Dread galloping. This is plate 707, captioned "'Dread' galloping" from Eadweard Muybridge. Animal locomotion: an electro-photographic investigation of consecutive phases of animal movements. 1872-1885 / published under the auspices of the University of Pennsylvania. Plates. The plates printed by the Photo-Gravure Company. Philadelphia, 1887.
DOI: 10.25549/rbm-c58-5269
title: Dog Dread galloping

description: Dog Dread galloping. This is plate 707, captioned "'Dread' galloping" from Eadweard Muybridge. Animal locomotion: an electro-photographic investigation of consecutive phases of animal movements. 1872-1885 / published under the auspices of the University of Pennsylvania. Plates. The plates printed by the Photo-Gravure Company. Philadelphia, 1887.
DOI: 10.25549/rbm-c58-5276
title: Dog Ike galloping

description: Dog Ike galloping This is plate 708, captioned "'Ike' galloping" from Eadweard Muybridge. Animal locomotion: an electro-photographic investigation of consecutive phases of animal movements. 1872-1885 / published under the auspices of the University of Pennsylvania. Plates. The plates printed by the Photo-Gravure Company. Philadelphia, 1887.
DOI: 10.5281/zenodo.18699094
title: Linked collectors and determiners for: The Ichthyology Collection at the Naturkundemuseum Stuttgart.

description: Natural history specimen data linked to collectors and determiners held within, "The Ichthyology Collection at the Naturkundemuseum Stuttgart". Claims or attributions were made on Bionomia by volunteer Scribes, https://bionomia.net/dataset/6aca6910-1f48-434d-ba57-a4a639ede7d9 using specimen data from the dataset aggregated by the Global Biodiversity Information Facility, https://gbif.org/dataset/6aca6910-1f48-434d-ba57-a4a639ede7d9. Formatted as a Frictionless Data package.
DOI: 10.5281/zenodo.18129213
title: Linked collectors and determiners for: The Ichthyology Collection at the Naturkundemuseum Stuttgart.

description: Natural history specimen data linked to collectors and determiners held within, "The Ichthyology Collection at the Naturkundemuseum Stuttgart". Claims or attributions were made on Bionomia by volunteer Scribes, https://bionomia.net/dataset/6aca6910-1f48-434d-ba57-a4a639ede7d9 using specimen data from the dataset aggregated by the Global Biodiversity Information Facility, https://gbif.org/dataset/6aca6910-1f48-434d-ba57-a4a639ede7d9. Formatted as a Frictionless Data package.
DOI: 10.5281/zenodo.18683695
title: Deterministic prediction registry: Solar anomaly alert and seismic risk (February 2026).
title: Référentiel de prédiction déterministe : Alerte solaire et sismique (Février 2026).

description: Ce dépôt contient des jeux de données métrologiques de haute précision et des modèles de calcul relatifs à la physique fréquentielle et à la modélisation de signaux complexes. Les travaux présentés ici concernent l'identification de signatures de phase dans les systèmes dynamiques.

Pour des raisons de confidentialité stratégique et de protection du secret industriel, l'accès aux fichiers est strictement restreint (Closed Access). Ce record fait office de preuve d'antériorité et de scellage temporel certifié pour des découvertes de métrologie fondamentale.

Référence de Protection : L'intégralité du contenu est couverte par un dépôt de propriété intellectuelle auprès de l'INPI (e-Soleau). Toute demande d'information doit faire l'objet d'une procédure formelle d'identification auprès de l'auteur.
DOI: 10.5281/zenodo.18683694
title: Deterministic prediction registry: Solar anomaly alert and seismic risk (February 2026).
title: Référentiel de prédiction déterministe : Alerte solaire et sismique (Février 2026).

description: Ce dépôt contient des jeux de données métrologiques de haute précision et des modèles de calcul relatifs à la physique fréquentielle et à la modélisation de signaux complexes. Les travaux présentés ici concernent l'identification de signatures de phase dans les systèmes dynamiques.

Pour des raisons de confidentialité stratégique et de protection du secret industriel, l'accès aux fichiers est strictement restreint (Closed Access). Ce record fait office de preuve d'antériorité et de scellage temporel certifié pour des découvertes de métrologie fondamentale.

Référence de Protection : L'intégralité du contenu est couverte par un dépôt de propriété intellectuelle auprès de l'INPI (e-Soleau). Toute demande d'information doit faire l'objet d'une procédure formelle d'identification auprès de l'auteur.
DOI: 10.25549/rbm-c58-5279
title: Dog Ike galloping

description: Dog Ike galloping This is plate 708, captioned "'Ike' galloping" from Eadweard Muybridge. Animal locomotion: an electro-photographic investigation of consecutive phases of animal movements. 1872-1885 / published under the auspices of the University of Pennsylvania. Plates. The plates printed by the Photo-Gravure Company. Philadelphia, 1887.
DOI: 10.5281/zenodo.18129215
title: Linked collectors and determiners for: A Revised Sectional Classification of Plukenetia L. (Euphorbiaceae, Acalyphoideae) with Four New Species from South America.

description: Natural history specimen data linked to collectors and determiners held within, "A Revised Sectional Classification of Plukenetia L. (Euphorbiaceae, Acalyphoideae) with Four New Species from South America". Claims or attributions were made on Bionomia by volunteer Scribes, https://bionomia.net/dataset/7796dd75-a996-400d-be9e-78c6edd2cc8f using specimen data from the dataset aggregated by the Global Biodiversity Information Facility, https://gbif.org/dataset/7796dd75-a996-400d-be9e-78c6edd2cc8f. Formatted as a Frictionless Data package.