DOI: 10.5281/zenodo.15855121
title: Long-Term Pathway Activation in Cardiac Ventricular Tissues Following Gamma and simGCRsim Irradiation. Additional Data.

description: The dataset contains additional/supplementary figures and tables associated with the manuscript entitled "Long-Term Pathway Activation in Cardiac Ventricular Tissues Following Gamma and simGCRsim Irradiation" to be submitted to Radiation Research journal (https://meridian.allenpress.com/radiation-research).

This version contains the original  additional/supplementary figures and tables as well as new ones prepared during revision in response to the Reviewer's comments.

 

The contents of the dataset are the following:

01.Additional_TableS1.xlsx - Additional Table S1. Sample-wise RNA sequencing QC statistics.

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02.Additional_TablesS2-S9.xlsx - Additional Tables S1-S9:

Additional Table S1. Differential deregulation analysis of log₂PSF values in LV tissue of males: Gamma-IR vs. Sham group. 

Additional Table S2. Differential deregulation analysis of log₂PSF values in LV tissue of males: simGCRsim-IR vs. Sham group. 

Additional Table S3. Differential deregulation analysis of log₂PSF values in LV tissue of females: Gamma-IR vs. Sham group. 

Additional Table S4. Differential deregulation analysis of log₂PSF values in LV tissue of females: simGCRsim-IR vs. Sham group. 

Additional Table S5. Differential deregulation analysis of log₂PSF values in RV tissue of males: Gamma-IR vs. Sham group. 

Additional Table S6. Differential deregulation analysis of log₂PSF values in RV tissue of males: simGCRsim-IR vs. Sham group. 

Additional Table S7. Differential deregulation analysis of log₂PSF values in RV tissue of females: Gamma-IR vs. Sham group. 

Additional Table S8. Differential deregulation analysis of log₂PSF values in RV tissue of females: simGCRsim-IR vs. Sham group. 

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03.Additional_Figures.pdf - Additional Figures S1-S34: 

Figure S1. Pathway activity perturbations in the KEGG Cell cycle pathway in LV tissue of female animals in response to Gamma-IR.

Figure S2. Pathway activity perturbations in the KEGG Chemokine signaling pathway in LV tissue of female animals in response to simGCRsim-IR.

Figure S3. Pathway activity perturbations in the KEGG Fc gamma R-mediated phagocytosis pathway in LV tissue of female animals in response to simGCRsim-IR. 

Figure S4. Pathway activity perturbations in the KEGG Complement and coagulation cascades pathway in LV tissue of female animals in response to simGCRsim-IR.

Figure S5. Pathway activity perturbations in the KEGG Fc epsilon RI signaling pathway in LV tissue of female animals in response to simGCRsim-IR. 

Figure S6. Pathway activity perturbations in the KEGG B cell receptor signaling pathway in LV tissue of female animals in response to simGCRsim-IR. 

Figure S7. Pathway activity perturbations in the KEGG TNF signaling pathway in LV tissue of female animals in response to simGCRsim-IR.

Figure S8. Pathway activity perturbations in the KEGG VEGF signaling pathway in LV tissue of female animals in response to simGCRsim-IR. 

Figure S9. Pathway activity perturbations in the KEGG HIF-1 signaling pathway in LV tissue of female animals in response to simGCRsim-IR.

Figure S10. Pathway activity perturbations in the KEGG ERBB signaling pathway in LV tissue of female animals in response to simGCRsim-IR.

Figure S11. Pathway activity perturbations in the KEGG RAP1 signaling pathway in LV tissue of female animals in response to simGCRsim-IR.

Figure S12. Pathway activity perturbations in the KEGG cGMP-PKG signaling pathway in LV tissue of female animals in response to simGCRsim-IR.

Figure S13. Pathway activity perturbations in the KEGG JAK-STAT signaling pathway in LV tissue of female animals in response to simGCRsim-IR. 

Figure S14. Pathway activity perturbations in the KEGG PPAR signaling pathway in RV tissue of male animals in response to Gamma-IR. 

Figure S15. Pathway activity perturbations in the KEGG Hedgehog signaling pathway in RV tissue of male animals in response to Gamma-IR. 

Figure S16. Pathway activity perturbations in the KEGG HIF-1 signaling pathway in RV tissue of male animals in response to Gamma-IR. 

Figure S17. Pathway activity perturbations in the KEGG HIF-1 signaling pathway in RV tissue of male animals in response to Gamma-IR. 

Figure S18. Pathway activity perturbations in the KEGG cAMP signaling pathway in RV tissue of male animals in response to Gamma-IR. 

Figure S19. Pathway activity perturbations in the KEGG TGF-beta signaling pathway in RV tissue of male animals in response to Gamma-IR.

Figure S20. Pathway activity perturbations in the KEGG VEGF signaling pathway in RV tissue of male animals in response to Gamma-IR. 

Figure S21. Pathway activity perturbations in the KEGG AMPK signaling pathway in RV tissue of male animals in response to Gamma-IR. 

Figure S22. Pathway activity perturbations in the KEGG NF-KAPPA B signaling pathway in RV tissue of male animals in response to simGCRsim-IR. 

Figure S23. Pathway activity perturbations in the KEGG RAS signaling pathway in RV tissue of male animals in response to simGCRsim-IR. 

Figure S24. Pathway activity perturbations in the KEGG VEGF signaling pathway in RV tissue of male animals in response to simGCRsim-IR.

Figure S25. Pathway activity perturbations in the KEGG PPAR signaling pathway in RV tissue of male animals in response to simGCRsim-IR. 

Figure S26. Pathway activity perturbations in the KEGG HIF-1 signaling pathway in RV tissue of male animals in response to simGCRsim-IR.

Figure S27. Pathway activity perturbations in the KEGG cAMP signaling pathway in RV tissue of male animals in response to simGCRsim-IR. 

Figure S28. Pathway activity perturbations in the KEGG PI3K-AKT signaling pathway in RV tissue of male animals in response to simGCRsim-IR.

Figure S29. Pathway activity perturbations in the KEGG NOD-like signaling pathway in RV tissue of male animals in response to simGCRsim-IR.

Figure S30. Pathway activity perturbations in the KEGG Apoptosis pathway in RV tissue of male animals in response to simGCRsim-IR. 

Figure S31. Pathway activity perturbations in the KEGG B cell receptor signaling pathway in RV tissue of male animals in response to simGCRsim-IR. 

Figure S32. Pathway activity perturbations in the KEGG Endocrine resistance pathway in RV tissue of male animals in response to simGCRsim-IR. 

Figure S33. Pathway activity perturbations in the KEGG B cell receptor signaling pathway in RV tissue of male animals in response to simGCRsim-IR.

Figure S34. Pathway activity perturbations in the KEGG Hedgehog signaling pathway in RV tissue of male animals in response to simGCRsim-IR. 

Figure S35. Pathway activity perturbations in the KEGG Rap1 signaling pathway in RV tissue of male animals in response to simGCRsim-IR.