cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.28366244.v1
title: Supplementary Material for: GAPDH, β-actin, and β-tubulin display age-dependent protein expression changes in the mouse cortex during development

description: GAPDH, β-actin, and β-tubulin are essential housekeeping proteins commonly used as reference controls for protein expression studies. GAPDH is a key glycolytic enzyme that facilitates the production of cellular energy, while β-actin and β-tubulin are major structural components of the cytoskeleton. Besides their well-established housekeeping functions, emerging studies have demonstrated critical roles for these proteins in brain developmental and pathological processes. However, few studies have examined how the expression patterns of these proteins change throughout mammalian brain development to adulthood. Considering the dynamic structural and functional changes that occur during brain development and the roles of GAPDH, β-actin, and β-tubulin in related biological processes, we investigated the developmental expression levels of these proteins in the mouse cortex at various embryonic (E15-P0) and postnatal (P0-P20, adult) stages using western blotting analysis with total protein normalization. We identified a substantial increase in GAPDH protein levels and a decrease in β-actin and β-tubulin in protein levels in the mouse cortex between birth and early adulthood, which occurred during the second week of postnatal life. Analysis of RNA-seq data from the ENCODE Consortium revealed correlated changes at the RNA transcript level. Overall, our study reveals robust age-dependent changes in cortical GAPDH, β-actin, and β-tubulin expression levels during mouse postnatal development and suggests precautions when using these proteins as reference controls in cortical development studies.
DOI: 10.6084/m9.figshare.5721448.v1
title: Additional file 4: Table S4. of Tsetse fly (Glossina pallidipes) midgut responses to Trypanosoma brucei challenge

description: Major (top ten) secreted/non-secreted differentially expressed genes in carcases of teneral G. pallidipes tsetse flies 24 or 48 h post-challenge by T. b. brucei parasites. * = treatment transcriptome; ** = reference trancriptome. (XLSX 351 kb)
DOI: 10.6084/m9.figshare.28092131.v1
title: <b>The host restriction factor SERINC5 inhibits HIV-1 transcription by negatively regulating NF-κB signaling</b>

description: <b>The host restriction factor SERINC5 inhibits HIV-1 transcription by negatively regulating NF-κB signaling</b>
DOI: 10.17632/jzfknp7sjv
title: Data for: The development of stationary battery storage systems in Germany – Status 2020

description: The Forschungszentrum Jülich (FZJ IEK-3) has been collecting the data of large-scale battery storage systems (LSS) in Germany since 2012. It contains location, installed capacity, installed power, investment, battery technology, commissioning date, operational status, area of application, and further information on the different LSS projects. We conducted our research through the evaluation of many press releases, prequalification results for ancillary services and bilateral contact to project planners and owners. The database is constantly updated. It contains both realized and planned BSS. The database is not exhaustive, as not all realized projects have publicly available information that can be included in it. Furthermore, storage systems outside of Germany, which are operating at least partly on the German market, are not included in the database. The project-specific sources are also included in the database to make the extended search for any information easier. The database was published together with our paper "The Development of Stationary Battery Storage Systems in Germany – Status 2020". The database provides an update to the database (http://dx.doi.org/10.17632/2rjg6v32d8.1) which was published together with our paper "The Development of Stationary Battery Storage Systems in Germany – A Market Review".
DOI: 10.6084/m9.figshare.28296422.v1
title: Supplementary Material for: Hepatocellular carcinoma with multiple primary malignancy: A Retrospective Study of 106 Cases

description: Abstract
Background: Multiple primary malignancies (MPM) are a rare scenario, particularly in patients with hepatocellular carcinoma (HCC). Research addressing MPM patients with HCC is limited. Therefore, we conducted a retrospective study to explore the clinical features and outcomes of MPM patients involving HCC.
Methods: We retrospectively analyzed records of patients diagnosed with HCC from January 2013 to October 2023 in the First Affiliated Hospital of Xiamen University. HCC patients with extrahepatic tumors were identified. Their clinical characteristics and survival data were were further analyzed.
Results:Among the 1556 patients with HCC, 106 (6.8%) were identified with EHPM, of which 29 were synchronous and 77 were metachronous. A total of 96 patients had double primary cancers, and 10 patients had triple primary cancers. The most common EHPMs were lung cancer (15%), followed by colorectal tumors and stomach cancer. Compared with the synchronous group, the curative treatment rate of HCC and EHPM in the metachronous group is higher. During follow-up period, 29 patients died, of which 20 (69%) died from HCC-related causes. The median overall survival (OS) time was 88 months, with 1-, 3-, 5-, and 10-year cumulative survival rates of 92.4%, 88%, 82.5%, and 69.6%, respectively. The 1-, 3-, and 5-year HCC-specific OS (HOS) rates were 81.8%, 75.8%, and 71.9%, respectively. Univariate analysis revealed that Child-Pugh class (B-C), HCC tumor size &gt;5cm, non-radical treatment for HCC or EHPM, HCC recurrence, BCLC staging (C-D), and synchronous appearance were significantly associated with shorter OS and HOS. Factors such as Childs class, tumor size, treatment modality, and synchronous presentation were identified as independent predictors of OS through Cox analysis. Childs class, tumor size, non-radical treatment, BCLC staging, and HCC recurrence were found to be independent factors affecting HOS.
Conclusions: The occurrence of extrahepatic primary tumors is not rare, underscoring the importance for oncologists being alert to the development of secondary tumor development in HCC patients. However, the co-occurrence of other primary tumors alongside HCC does not appear to worsen patient prognosis. Notably, curative resection, where feasible, emerges as a vital factor in extending patient survival.
DOI: 10.6084/m9.figshare.3513491.v1
title: Appendix A. Three tables listing Δ14C values and corresponding estimated turnover times of litter, light, and heavy SOM fractions.

description: Three tables listing Δ14C values and corresponding estimated turnover times of litter, light, and heavy SOM fractions.
DOI: 10.17632/7mrhxrt9kr
title: Supplementary data for manuscript 'Dataset on effect of decolourisation on metabolomic profile of Moringa oleifera leaf powder'

description: Raw and processed data of metabolites obtained from the extraction of Moringa oleifera leaf powder using the solvent mixture of methanol and water (ratio 80% to 20%)
DOI: 10.6084/m9.figshare.14999907.v1
title: Test Instances

description: A set of MKP instances used to benchmark PSOQL, PSOQLAV and PSOSS.
DOI: 10.6084/m9.figshare.13118549.v1
title: Genomic and phenotypic analysis of COVID-19-associated pulmonary aspergillosis isolates of Aspergillus fumigatus

description: Data associated with "Genomic and phenotypic analysis of coronavirus-associated pulmonary aspergillosis isolates of Aspergillus fumigatus" by Steenwyk et al.
DOI: 10.6084/m9.figshare.15186816.v1
title: Supplementary Material for: Use of Antibiotics during Immune Checkpoint Inhibitor Treatment Is Associated with Lower Survival in Hepatocellular Carcinoma

description: <b><i>Background:</i></b> Recent studies suggested that use of antibiotics may interfere with treatment responses to immune checkpoint inhibitors (ICIs). We determined whether concurrent use of antibiotics during ICI therapy was associated with adverse outcomes in patients with advanced hepatocellular carcinoma (HCC). <b><i>Methods:</i></b> This is a territory-wide retrospective cohort study including all advanced HCC patients who received ICIs (nivolumab, pembrolizumab, or ipilimumab) between January 2014 and December 2019. Exclusion criteria included prior liver transplantation and use of cabozantinib, regorafenib, or ramucirumab. The exposure of interest was concurrent antibiotic use within 30 days before or after the commencement of ICI. The adjusted hazard ratio (aHR) of cancer-related mortality and all-cause mortality with antibiotic use was derived by propensity score (PS) matching in 1:2 ratio of covariates including baseline characteristics, causes of cirrhosis, Child-Pugh status, prior HCC treatment, comorbidities, concurrent medications, and laboratory results including alpha fetoprotein. <b><i>Results:</i></b> A total of 395 HCC patients who had received ICIs were included. During a median follow-up of 16.5 months (interquartile range [IQR]: 5.6–44.3), there were 286 (72.4%) deaths including 231 cancer-related deaths. The median time from the first ICI to event was 7.7 months (IQR: 4.0–16.8). PS matching of 56 antibiotic users with 99 nonusers showed that concurrent antibiotic use with ICI was associated with higher cancer-related (aHR: 1.66; 95% CI: 1.08–2.54) and all-cause mortality (aHR: 1.63; 95% CI: 1.17–2.28). <b><i>Conclusions:</i></b> Concurrent antibiotic use during immunotherapy was associated with higher mortality in patients with advanced HCC. Further studies should examine the role of gut dysbiosis on responses to ICI.
DOI: 10.6084/m9.figshare.1609803.v1
title: Excel file for behavioural data presented in paper

description: The excel file contains means for each participant and condition across Experiments 1-3.
DOI: 10.17632/kmtrgb4jf6
title: VRPDPTW

description: This is real-world instances about VRP with simultaneous delivery and pickup and time windows.
DOI: 10.25403/upresearchdata.27126264.v1
title: Community work programme (CWP) agriculture sector participants' views and experiences to its contribution to rural development and livelihoods

description: Data was collected from 48 participants. Two of the participants were government officials who work and also part of the implementing team for the Community Work Programme (CWP) agriculture sector in the Eastern Cape province. Five of the participants were CWP agriculture sector site supervisors, and 41 were the CWP agriculture sector beneficiaries. The data was collected through semi-structured interviews where the researcher explored the role of the CWP agriculture sector in rural development and bringing social change in rural areas' former homelands. Data was analyzed through thematic analysis. Participants believed that CWP has provided them with food and improved their lives; although their stipend is not enough, but they can afford to support their families. There are different CWP homesteads and communal gardens where they grow vegetables to support vulnerable groups and support learners' feeding schemes. There are challenges, such as participant's lack of uniforms, seeds, training, and work tools.
DOI: 10.6084/m9.figshare.21929676.v1
title: Supplementary Material for: Evaluation of a web-based intervention for patients with Gestational Trophoblastic Disease: a randomized controlled trial

description: Objective Gestational Trophoblastic Diseases (GTD) comprise a group of rare diseases originating from the trophoblast, affecting women of child-bearing age. Providing optimal information to patients with a rare disease is challenging, because of the small number of patients and limited clinical expertise of many healthcare professionals. Both knowledge and lack of knowledge in patients may influence illness perception. We investigated whether a web-based interactive intervention influences illness perception and knowledge in women with GTD. Design Multicenter randomized control trial. Setting General and academic hospitals in the Netherlands. Population Newly diagnosed GTD patients between 2017-2019. Methods Sixty-nine patients were randomized between direct access or postponed access to an online tool on GTD and received online questionnaires about illness perception, knowledge and anxiety. The main outcome measures were illness perception (primary outcome measure) and knowledge (secondary outcome measure) Results Patients using the online tool were satisfied with the information from the tool (92%). Although they had a higher level of knowledge compared to the control group (p = 0.006), illness perception did not change. Also, no differences in levels of anxiety, depression and distress were observed between the groups. Limitations: Participants had access to other information sources and many searched other websites. It is unknown what kind of websites were visited and when. It is unknown if the increased knowledge levels and low levels of distress will sustain over time as no long term follow-up took place. Healthcare professionals were not interviewed on how they experienced the consultation before and after using the tool by the patients. Conclusions The online tool did not change illness perception, but was shown to be valuable for newly-diagnosed GTD patients to gain knowledge. The improvement in knowledge after digital education, indicates that this tool can be used as an effective method of supporting GTD patients’ informational needs without causing extra distress.
DOI: 10.6084/m9.figshare.23118758.v2
title: SNGNN

description: An improved graph neural network (GNN) and a self and neighborhood merged graph neural network (SNGNN) were proposed. "SNGNN.py" is the proposed model. "attribute417.csv" and "edgeattribute417.csv" are the node feature file and edge feature file requiredas input to the SNGNN mode respectively. "Focalloss.py" and "configure.py" are the supporting file required by SNGNN mpdel. <br>
DOI: 10.6084/m9.figshare.7878086.v2
title: Compendiums of cancer transcriptome for machine learning applications

description: "Scientific Data_2.R" R-code has been used to generate merged microarray-acquired transcriptome datasets (MMDs), comprising a total of 8,386 samples across 11 major cancer types.<br>The preprint is available at bioRxiv:http://doi.org/10.1101/353698<br><br>Application of lung MMD:https://www.nature.com/articles/s41467-017-01430-6<br><br>Predictive model development:https://www.nature.com/articles/sdata2018136<br><br><br>
DOI: 10.17632/765jbfjc5k
title: Full Immunoblot images

description: Full immunoblot images for "Tau Oligomer Induced HMGB1 Release Contributes to Cellular Senescence and Neuropathology Linked to Alzheimer's Disease and Frontotemporal Dementia".
DOI: 10.6084/m9.figshare.3568581.v1
title: Appendix B. Description of primary variables and data sources used to parameterize the endotherm model.

description: Description of primary variables and data sources used to parameterize the endotherm model.
DOI: 10.6084/m9.figshare.14184813.v1
title: Pharmacokinetics and metabolism of brexpiprazole, a novel serotonin-dopamine activity modulator and its main metabolite in rat, monkey and human

description: The pharmacokinetics of brexpiprazole were investigated in the <i>in vitro</i> and <i>in vivo</i>. The total body clearance of brexpiprazole in rat and monkey was 2.32 and 0.326 L/h/kg, respectively, after intravenous administration, and oral availability was 13.6% and 31.0%, respectively. Dose-dependent exposures were observed at dose ranges between 1–30 mg/kg in the rat and 0.1–3 mg/kg in the monkey. Brexpiprazole distributed widely to body tissues, and V<sub>d,z</sub> were 2.81 and 1.82 L/kg in rat and monkey, respectively. The serum protein binding of brexpiprazole was 99% or more in animals and human. Uniform distribution character among the species was suggested by a traditional animal scale-up method. A common main metabolite, DM-3411 was found in animals and humans in the metabolic reactions with the liver S9 fraction. CYP3A4 and CYP2D6 were predominantly involved in the metabolism. The affinity of DM-3411 for D<sub>2</sub> receptors was lower than that of brexpiprazole, and neither DM-3411 nor any metabolites with affinity other than M3 were detected in the brain, demonstrating that brexpiprazole is only involved in the pharmacological effects. Overall, brexpiprazole has a simple pharmacokinetic profile with good metabolic stability, linear kinetics, and no remarkable species differences with regard to metabolism and tissue distribution.
DOI: 10.6084/m9.figshare.16602320.v4
title: Model data

description: Raw model activations to 2,162 faces
DOI: 10.6084/m9.figshare.5463604.v1
title: BARM Counts LMO 2012

description: Tables with counts per sample and gene/annotation.The counts are either sum of raw counts of reads mapping or sum of tpm values. The counts for taxonomy are given in individual files per level and in a combined file for all levels. These counts are for the time series data of Hugerth et al (2015) from the Linnaeus Microbial Observatory (LMO) in the Baltic Sea.
DOI: 10.6084/m9.figshare.26536315.v1
title: Textura.R

description: Pedometric data collection in La Molina, Peru
DOI: 10.6084/m9.figshare.22822355.v1
title: CDH Spatial Transcriptomics

description: Differentially expressed gene list
DOI: 10.6084/m9.figshare.852989.v2
title: Kirby multivariate template

description: Multivariate template contstructed from The Multi-Modal MRI Reproducibility Resource (Kirby data). Intended for use with Advanced Normalization Tools (ANTs)
DOI: 10.6084/m9.figshare.19746904.v2
title: AvcID_Nature Microbiology_Datasets

description: The dataset contains raw data values for the manuscript NMICROBIOL-21123099A, including main text figures and supplemental. The title and authors are as follows: <br> Phage defence by deaminase-mediated depletion of deoxynucleotides in Bacteria <br> Brian Y. Hsueh1#, Geoffrey B. Severin2#@, Clinton A. Elg3, Evan J. Waldron4$, Abhiruchi Kant4, Alex J. Wessel1, John A. Dover2, Christopher R. Rhoades1, Benjamin J. Ridenhour5, Kristin N. Parent2, Matthew B. Neiditch4, Janani Ravi1,6, Eva M. Top3, and Christopher M. Waters1* <br>
DOI: 10.6084/m9.figshare.21626993.v1
title: List gene on sengon chloroplast genome

description: This project contains data files results from chloroplast genome assembly using short-read and long-read sequencing technology of Sengon (<em>Falcataria moluccana</em>)
DOI: 10.6084/m9.figshare.27619689.v1
title: <b>Mixed mating system and intraspecific variation in lizard pollination of </b><b><i>Withania frutescens </i></b><b>(L.) </b><b>Pauquy</b>

description: Dataset and R code related to the unpublished research Mixed mating system and intraspecific variation in lizard pollination of <i>Withania frutescens </i>(L.) Pauquy.
DOI: 10.6084/m9.figshare.23808960.v1
title: PRINCIPLES OF TRAFFIC ORGANIZATION IN ANT TRANSPORTATIONNETWORKS

description: Includes raw data and analysis routines for extracting organizational information from videos of foraging ants
DOI: 10.6084/m9.figshare.17091188.v1
title: Supplementary Material for: Simple Scoring System for Predicting TACE Unsuitable among Intermediate-Stage Hepatocellular Carcinoma Patients in the Multiple Systemic Treatment Era

description: <b><i>Background/Aim:</i></b> With the development of systemic treatment methods for unresectable hepatocellular carcinoma (uHCC), the concept of unsuitable for transcatheter arterial chemoembolization (TACE) has become important. This study aimed to establish a simple predictive scoring system for determining TACE unsuitable status. <b><i>Materials/Methods:</i></b> From 1998 to 2015, 196 patients with intermediate-stage uHCC with Child-Pugh A (score 5:6 = 108:88) and given TACE as the initial treatment were enrolled. At the baseline, tumor burden (Milan criteria-out, up-to-7 in/out, and up-to-11 in/out: 0–2 points) and modified albumin-bilirubin grade 1/2a or 2b (0–1 point) were added to determine the score for TACE unsuitable (CITRUS-MICAN score; low &lt;2 and high ≥2). In addition, a previously reported tumor marker (TM) score, in which alpha-fetoprotein (AFP) was ≥100 ng/mL, fucosylated AFP ≥10%, and des-gamma-carboxy prothrombin ≥100 mAU/mL (each 1 point) (total 0, 1, or ≥2 points), was used for additionally evaluating tumor malignancy potential. Prognosis was retrospectively evaluated based on those scores. <b><i>Results:</i></b> Median survival time (MST) was better for low compared to high CITRUS-MICAN score (42.0 vs. 26.4 months) (<i>p</i> = 0.002). A 2-step evaluation using the combination of CITRUS-MICAN and TM scores showed an MST of 43.2 months for low CITRUS-MICAN/TM score 0/1 (rank-A) and 39.6 months for low CITRUS-MICAN/TM score ≥2 (rank-B2), while it was 46.8 months for high CITRUS-MICAN/TM score 0 (rank-B1), 28.8 months for high CITRUS-MICAN/TM score 1 (rank-B2), and 22.8 months for high CITRUS-MICAN/TM score ≥2 (rank-C). For rank-A cases (<i>n</i> = 51), MST was 43.2 months, while it was 46.8 months for rank-B1 (<i>n</i> = 12), 31.2 months for rank-B2 (<i>n</i> = 82), and 22.8 months for rank-C (<i>n</i> = 51) (<i>p</i> = 0.001). <b><i>Conclusion:</i></b> The results showed that rank-C indicates absolute TACE unsuitable status. For rank-A patients, good prognosis with TACE can be expected, while TACE refractoriness status during the clinical course should be carefully evaluated so as to anticipate the appropriate timing for switching to systemic treatment in rank-B1 and -B2 patients.
DOI: 10.6084/m9.figshare.19307249.v1
title: Supplementary Material for: Effects of L-Carnitine Treatment on Kidney Mitochondria and Macrophages in Mice with Diabetic Nephropathy

description: <b><i>Introduction:</i></b> In diabetic nephropathy (DN), mitochondrial dysfunction and leakage of mitochondrial DNA (mtDNA) are caused by the downregulation of superoxide dismutase 2 (SOD2). mtDNA induces the activation of Toll-like receptor (TLR) 9, which is present in macrophages (Mφs), and triggers their activation. <b><i>Methods:</i></b> We orally administered L-carnitine, which exerts protective effects on the mitochondria, to obesity-induced DN (db/db) mice for 8 weeks. We then investigated the effects of L-carnitine on kidney mitochondrial reactive oxygen species (mtROS) production, circulating mtDNA content, and kidney CD11b<sup>high</sup>/CD11b<sup>low</sup> Mφ functions. <b><i>Results:</i></b> In db/db mice, mtROS production increased in proximal tubular cells and kidney CD11b<sup>low</sup> Mφs; both Mφ types showed enhanced TLR9 expression. L-Carnitine treatment suppressed mtROS production in both proximal tubular cells and CD11b<sup>low</sup> Mφs (<i>p</i> &lt; 0.01), with improved SOD2 expression in the kidney (<i>p</i> &lt; 0.01), decreased circulating mtDNA content, and reduced albuminuria. Moreover, it suppressed Mφ infiltration into kidneys and reduced TLR9 expression in Mφs (<i>p</i> &lt; 0.01), thereby lowering tumor necrosis factor-α production in CD11b<sup>high</sup> Mφs (<i>p</i> &lt; 0.05) and ROS production by CD11b<sup>low</sup> Mφs (<i>p</i> &lt; 0.01). Collectively, these changes alleviated DN symptoms. <b><i>Conclusion:</i></b> The positive effects of L-carnitine on DN suggest its potential as a novel therapeutic agent against obesity-linked DN.
DOI: 10.6084/m9.figshare.19813378.v1
title: Teacher Perceptions Regarding the Purposes of K-12 Education_May 22, 2022_09.38.csv

description: Data set of teacher ratings of 11 ideal and experience-based purposes of education and 14 sources of beliefs.
DOI: 10.6084/m9.figshare.28674755.v1
title: DIKWP framework: Intelligentization, green innovation, and servitization for manufacturing sustainability in circular economy

description: This is the experimental data of the manuscript entitled "DIKWP framework: Intelligentization, green innovation, and servitization for manufacturing sustainability in circular economy".
DOI: 10.17632/w9jbjyhdc2
title: Database_"Mental health of left behind children in Vietnam"

description: Database:  "Mental Health among Left-Behind Children in Vietnam: Role of Resilience"
The number of Observations: 792
The number of Variables: 31
Country: Vietnam