cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.17632/5p69g6d9x3.1
title: Inhibition of neuroinflammation and pyroptosis by Fo-Shou-San enhances cognitive function in rats with vascular dementia

description: Context：Fo-Shou-San (FSS) is a well-known traditional Chinese medicine formula used for the treatment of gynecological and cerebrovascular diseases. However, the specific molecular mechanisms underlying its therapeutic effects on vascular dementia (VaD) remain unclear. 
Objective: Our objective is to elucidate the mechanistic role of FSS in anti-vascular dementia by suppressing both in vivo and in vitro inflammatory responses and pyroptosis.
Material and methods: We utilized the bilateral vertebral artery occlusion (2-VO) method to establish a VaD rat model and evaluated the therapeutic effects of FSS. Cognitive improvement in VaD rats following FSS treatment was assessed through behavioral experiments. Neuronal damage in the hippocampal region was observed using Nissl staining and hematoxylin-eosin (HE) staining. The expression of inflammatory cytokine genes and microglial cell activation in the rat hippocampal region was evaluated using RT-qPCR and quantitative immunohistochemistry. TUNEL staining, RT-qPCR, and Western blot techniques were employed to assess pyroptosis in the rat hippocampal tissue. Subsequently, based on high-performance liquid chromatography (HPLC) analysis, FSS derivatives were screened through molecular docking to identify the optimal compound that binds to the key pyroptosis target Caspase-1. Finally, in vitro validation demonstrated that FSS derivatives could inhibit the inflammatory response and pyroptosis induced by lipopolysaccharide (LPS) + adenosine triphosphate (ATP), in accordance with the results of molecular docking analysis.
Results: FSS improved cognitive impairment and neuronal damage in VaD rats established by 2-VO, while also inhibiting the inflammatory response and pyroptosis in the rat hippocampal tissue. Building upon the results of HPLC analysis, molecular docking predicted that FSS derivatives, such as Levistilide A (LA), Imperatorin (IMP), Caffeic Acid (CA), and Ferulic Acid (FA), demonstrated optimal binding affinity with the crucial pyroptosis target, Caspase-1. Validation through in vitro experiments revealed that LA and IMP significantly inhibited the inflammatory response and pyroptosis in LPS+ATP-induced BV2 cells. 
Discussion and conclusion: Our study indicates that FSS can exert neuroprotective effects on VaD rats by inhibiting inflammatory responses and pyroptosis. The active components in FSS, namely LA, and IMP, demonstrated significant inhibition of the inflammatory response and pyroptosis in LPS+ATP-induced BV2 cells. This suggests the potential therapeutic value of FSS in VaD treatment and provides a novel approach for the development of Caspase-1 inhibitors in clinical settings.
DOI: 10.17632/3xksjw9xtp.1
title: Ensaio de Dureza Brinell - CUSN8ZN4PB1

description: Ensaio de dureza Brinell
DOI: 10.6084/m9.figshare.5914759
title: Analysis of genetic diversity and population structure of a worldwide collection of <i>Corchorus olitorius</i> L. germplasm using microsatellite markers

description: Jute (<i>Corchorus</i> spp.) is the second most important global natural fiber crop after cotton. Analyses of the genetic diversity and population structure of the germplasm are useful for improving <i>Corchorus</i> breeding. Recently, limited studies on genetic diversity and population structure in jute have been carried out. In the present study, the genetic diversity and population structure of 453 accessions in <i>Corchorus olitorius</i> L., including cultivars, landraces, genetic materials and wild germplasm, were analyzed using 39 SSR markers. The results showed that <i>C. olitorius</i> populations have moderate genetic diversity with an average gene diversity (<i>h<sub>e</sub></i>) value of 0.322 and polymorphic information content (PIC) value of 0.270 in all accessions. Regarding the geographic distribution, the average <i>h<sub>e</sub></i> and PIC values were highest in Kenya (0.332, 0.273), followed by Nepal (0.307, 0.259), and China (0.303, 0.253). Among the different germplasm types, the wild germplasm showed higher genetic diversity with an average <i>h<sub>e</sub></i> value of 0.362 and PIC value of 0.299. The population structure analysis revealed two populations, Pop1 and Pop2; Pop1 was further divided into three subpopulations, and Pop2 was further divided into two subpopulations. These populations were verified by <i>F<sub>ST</sub></i> statistics, principal coordinate analysis (PCoA) and neighbour-joining trees. This study contributes to the knowledge about levels and distribution of genetic diversity of <i>C. olitorius</i> worldwide and provides clues about the origin of <i>C. olitorius.</i>
DOI: 10.6084/m9.figshare.5914759.v1
title: Analysis of genetic diversity and population structure of a worldwide collection of <i>Corchorus olitorius</i> L. germplasm using microsatellite markers

description: Jute (<i>Corchorus</i> spp.) is the second most important global natural fiber crop after cotton. Analyses of the genetic diversity and population structure of the germplasm are useful for improving <i>Corchorus</i> breeding. Recently, limited studies on genetic diversity and population structure in jute have been carried out. In the present study, the genetic diversity and population structure of 453 accessions in <i>Corchorus olitorius</i> L., including cultivars, landraces, genetic materials and wild germplasm, were analyzed using 39 SSR markers. The results showed that <i>C. olitorius</i> populations have moderate genetic diversity with an average gene diversity (<i>h<sub>e</sub></i>) value of 0.322 and polymorphic information content (PIC) value of 0.270 in all accessions. Regarding the geographic distribution, the average <i>h<sub>e</sub></i> and PIC values were highest in Kenya (0.332, 0.273), followed by Nepal (0.307, 0.259), and China (0.303, 0.253). Among the different germplasm types, the wild germplasm showed higher genetic diversity with an average <i>h<sub>e</sub></i> value of 0.362 and PIC value of 0.299. The population structure analysis revealed two populations, Pop1 and Pop2; Pop1 was further divided into three subpopulations, and Pop2 was further divided into two subpopulations. These populations were verified by <i>F<sub>ST</sub></i> statistics, principal coordinate analysis (PCoA) and neighbour-joining trees. This study contributes to the knowledge about levels and distribution of genetic diversity of <i>C. olitorius</i> worldwide and provides clues about the origin of <i>C. olitorius.</i>
DOI: 10.6084/m9.figshare.6963347
title: Additional file 1: of Characterization of kinase gene expression and splicing profile in prostate cancer with RNA-Seq data

description: Table S1. DE genes with p-value &lt; 0.05 and FDR &lt; 0.01. (XLSX 448 kb)
DOI: 10.17632/rmmdntvpft.1
title: SIBI: Official Indonesian Sign Language

description: The SIBINet image consists of 4500 images of Indonesian sign language words. Images dataset collected from Computer Laboratory, Informatics, Faculty of Engineering, Nusantara PGRI Kediri University, East Java, Indonesia. Images file were in format of .jpg. The sign language image was taken using the phone camera. The image data set in this study uses an official sign language established by the Ministry of Education and Culture of the Republic of Indonesia called SIBI. Image data consists of 50 Indonesian sign language word data. The data was taken from front positions. Each image then performs an augmentation process of blur, noise, horizontal flip and rotate into 9 images
DOI: 10.6084/m9.figshare.20064160.v1
title: Additional file 10 of The transcription factor LaMYC4 from lavender regulates volatile Terpenoid biosynthesis

description: Additional file 10: Table S1. Volatile compounds from control or treated with methyl jasmonate (MeJA) of lavender.
DOI: 10.6084/m9.figshare.20064163
title: Additional file 11 of The transcription factor LaMYC4 from lavender regulates volatile Terpenoid biosynthesis

description: Additional file 11: Table S2. Sequences of LaMYC4 and 22 MYCs from different plants.
DOI: 10.6084/m9.figshare.20064172.v1
title: Additional file 14 of The transcription factor LaMYC4 from lavender regulates volatile Terpenoid biosynthesis

description: Additional file 14: Table S5. Predicted functions of the LaMYC4 with the function of their homologs verified in Arabidopsis by phylogenetic analysis.
DOI: 10.6084/m9.figshare.6963374.v1
title: Additional file 3: of Characterization of kinase gene expression and splicing profile in prostate cancer with RNA-Seq data

description: Table S3. DS genes detected by both DSGseq and DEXseq. (XLSX 374 kb)
DOI: 10.6084/m9.figshare.20064169
title: Additional file 13 of The transcription factor LaMYC4 from lavender regulates volatile Terpenoid biosynthesis

description: Additional file 13: Table S4. Sequences of HMGR, FPPS, DXS, DXR, GPPS and TPS21.
DOI: 10.6084/m9.figshare.6963374
title: Additional file 3: of Characterization of kinase gene expression and splicing profile in prostate cancer with RNA-Seq data

description: Table S3. DS genes detected by both DSGseq and DEXseq. (XLSX 374 kb)
DOI: 10.6084/m9.figshare.20064172
title: Additional file 14 of The transcription factor LaMYC4 from lavender regulates volatile Terpenoid biosynthesis

description: Additional file 14: Table S5. Predicted functions of the LaMYC4 with the function of their homologs verified in Arabidopsis by phylogenetic analysis.
DOI: 10.6084/m9.figshare.6963347.v1
title: Additional file 1: of Characterization of kinase gene expression and splicing profile in prostate cancer with RNA-Seq data

description: Table S1. DE genes with p-value &lt; 0.05 and FDR &lt; 0.01. (XLSX 448 kb)
DOI: 10.6084/m9.figshare.6963359
title: Additional file 2: of Characterization of kinase gene expression and splicing profile in prostate cancer with RNA-Seq data

description: Table S2. DE kinase genes with p-value &lt; 0.05 and FDR &lt; 0.01. (XLSX 20 kb)
DOI: 10.6084/m9.figshare.6963359.v1
title: Additional file 2: of Characterization of kinase gene expression and splicing profile in prostate cancer with RNA-Seq data

description: Table S2. DE kinase genes with p-value &lt; 0.05 and FDR &lt; 0.01. (XLSX 20 kb)
DOI: 10.17632/7v3j44zpwj.1
title: climate change effect on cocoa farmers income, yield and livelihood

description: Immediate Impact:
Income and Food Security: Cocoa is a vital source of income for millions of farmers, particularly in West Africa. Understanding their perception of climate change's effect helps assess potential income losses and food insecurity risks. This knowledge informs targeted interventions like financial support, alternative income strategies, and food assistance programs.
Crop Management: Farmers' existing knowledge and beliefs about climate change influence their management decisions. Studying their understanding helps tailor extension services and training programs to address specific concerns and practices. This can lead to improved adaptation strategies like water conservation, shade management, and resistant crop varieties.
Long-term Sustainability:
Adapting to a Changing Climate: Cocoa production is highly sensitive to climatic variations. Understanding farmers' perceptions is crucial for developing long-term adaptation strategies that ensure the sustainability of the cocoa sector. This can involve breeding resilient cocoa varieties, promoting agroforestry practices, and investing in climate-smart infrastructure.
Building Resilience: By understanding farmers' needs and challenges, interventions can empower them to become more resilient to climate change. This includes fostering knowledge sharing, improving access to information and resources, and building collective action within communities. This ensures the long-term viability of their livelihoods and the cocoa industry itself.
Additional Benefits:
Policy and Advocacy: The study can inform policy decisions at various levels, from local governments to international organizations. This can lead to investments in climate-smart agriculture, fair trade practices, and sustainable supply chains.
Raising Awareness: Studying farmers' perspectives can raise awareness about the challenges they face and the impact of climate change on global food security and economic stability. This can encourage broader public support for climate action and sustainable practices.
DOI: 10.6084/m9.figshare.20064163.v1
title: Additional file 11 of The transcription factor LaMYC4 from lavender regulates volatile Terpenoid biosynthesis

description: Additional file 11: Table S2. Sequences of LaMYC4 and 22 MYCs from different plants.
DOI: 10.6084/m9.figshare.20064166.v1
title: Additional file 12 of The transcription factor LaMYC4 from lavender regulates volatile Terpenoid biosynthesis

description: Additional file 12: Table S3. Promoter sequence of LaMYC4 and Prediction element.
DOI: 10.6084/m9.figshare.23740650.v1
title: Additional file 6 of Integrated analysis of lncRNA/circRNA–miRNA–mRNA in the proliferative phase of liver regeneration in mice with liver fibrosis

description: Additional file 6: Supplementary Table S6. miRNA-RNA targets predicted by miRanda.
DOI: 10.6084/m9.figshare.6963395
title: Additional file 4: of Characterization of kinase gene expression and splicing profile in prostate cancer with RNA-Seq data

description: Table S4. DS kinase genes detected by both DSGseq and DEXseq. (XLSX 18 kb)
DOI: 10.17632/txfkwd4mdm.1
title: Cumulative effects of humour styles on human behaviour

description: The data that I have built delves into the intricate world of humour styles and their cumulative effects on human behaviour, employing integral calculus and numerical simulation. The study explores four distinct humour styles—Affiliative Humour (HA), Self-Enhancing Humour (HE), Aggressive Humour (HD), and Self-Defeating Humour (SD)—and investigates their influence on three key aspects of human behaviour—Positive Social Interactions (PSI), Stress Coping and Resilience (SCR), and Interpersonal Conflict (IC). Using simulated data and visualisations in Python, this analysis provides a unique perspective on the dynamic interplay between humour styles and their lasting impact on individuals over time.
DOI: 10.17632/myyjx4tpc3.1
title: Sample preparation CUSN8ZN4PB1

description: Sample preparation CUSN8ZN4PB1
DOI: 10.6084/m9.figshare.23740641.v1
title: Additional file 3 of Integrated analysis of lncRNA/circRNA–miRNA–mRNA in the proliferative phase of liver regeneration in mice with liver fibrosis

description: Additional file 3: Supplementary Table S3. Summary of all DE lncRNAs, DE circRNAs, DE miRNA and DE mRNAs identified in this study.
DOI: 10.6084/m9.figshare.23740641
title: Additional file 3 of Integrated analysis of lncRNA/circRNA–miRNA–mRNA in the proliferative phase of liver regeneration in mice with liver fibrosis

description: Additional file 3: Supplementary Table S3. Summary of all DE lncRNAs, DE circRNAs, DE miRNA and DE mRNAs identified in this study.
DOI: 10.6084/m9.figshare.23740644
title: Additional file 4 of Integrated analysis of lncRNA/circRNA–miRNA–mRNA in the proliferative phase of liver regeneration in mice with liver fibrosis

description: Additional file 4: Supplementary Table S4. DE mRNAs of each WGCNA modules.
DOI: 10.17632/dxkxdryzhx.1
title: X-RAY FLOURESCENCE CUSN8ZN4PB1 SAMPLE 02

description: X-RAY FLOURESCENCE CUSN8ZN4PB1 SAMPLE 02
DOI: 10.17632/sj5kjsft5j.1
title: Analise metalográfica CUSN8ZN4PB1 sample 01

description: Analise metalográfica CUSN8ZN4PB1 sample 01
DOI: 10.17632/pvbvy538s6.1
title: X-RAY FLUORESCENCE - CUSN8ZN4PB1 - SAMPLE 01

description: RAIOS X FLUORESCENCIA - CUSN8ZN4PB1 - SAMPLE 01
DOI: 10.6084/m9.figshare.23740598.v1
title: Additional file 4 of Transcriptome profile and immune infiltrated landscape revealed a novel role of γδT cells in mediating pyroptosis in celiac disease

description: Additional file 4: Table S1. The DEGs analysis between CeD and HC duodenal tissues in derivation cohort.
DOI: 10.6084/m9.figshare.23740610.v1
title: Additional file 8 of Transcriptome profile and immune infiltrated landscape revealed a novel role of γδT cells in mediating pyroptosis in celiac disease

description: Additional file 8: Table S7. The DEGs analysis between CeD and HC duodenal γδT cells.
DOI: 10.6084/m9.figshare.23740607
title: Additional file 7 of Transcriptome profile and immune infiltrated landscape revealed a novel role of γδT cells in mediating pyroptosis in celiac disease

description: Additional file 7: Table S6. Pyroptosis associated genes used in the "pyroptosis enrichment score" model.
DOI: 10.6084/m9.figshare.23740638
title: Additional file 2 of Integrated analysis of lncRNA/circRNA–miRNA–mRNA in the proliferative phase of liver regeneration in mice with liver fibrosis

description: Additional file 2: Supplementary Table S2. Summary of all lncRNAs, circRNAs, miRNAs, and mRNAs identified in this study.
DOI: 10.6084/m9.figshare.6963428
title: Additional file 6: of Characterization of kinase gene expression and splicing profile in prostate cancer with RNA-Seq data

description: Table S5. GO and KEGG enrichment analysis results for DE and DS genes. (XLSX 220 kb)
DOI: 10.17632/gs2ry5vn66.1
title: Caraterização Microestrutural CUSN8ZN4PB1

description: Caracterização de dados microestruturais da liga SAE 620 - CUSN8ZN4PB1
DOI: 10.6084/m9.figshare.23740601.v1
title: Additional file 5 of Transcriptome profile and immune infiltrated landscape revealed a novel role of γδT cells in mediating pyroptosis in celiac disease

description: Additional file 5: Table S2–S4. The GO, KEGG and Reactome analysis of DEGs between CeD and HC duodenal tissues in derivation cohort.
DOI: 10.6084/m9.figshare.23740604
title: Additional file 6 of Transcriptome profile and immune infiltrated landscape revealed a novel role of γδT cells in mediating pyroptosis in celiac disease

description: Additional file 6: Table S5. Pyroptosis associated genes identified from the Reactome database, GO database, and previous reports.
DOI: 10.6084/m9.figshare.6963428.v1
title: Additional file 6: of Characterization of kinase gene expression and splicing profile in prostate cancer with RNA-Seq data

description: Table S5. GO and KEGG enrichment analysis results for DE and DS genes. (XLSX 220 kb)
DOI: 10.17632/526t8fwsgw.1
title: Data for: Neurokinin-1 receptor antagonist inhibits enhanced anxiety and spatial memory caused by cosmic ray exposure of rats in a ground-based model

description: Experemental data
DOI: 10.6084/m9.figshare.23740598
title: Additional file 4 of Transcriptome profile and immune infiltrated landscape revealed a novel role of γδT cells in mediating pyroptosis in celiac disease

description: Additional file 4: Table S1. The DEGs analysis between CeD and HC duodenal tissues in derivation cohort.
DOI: 10.6084/m9.figshare.23740601
title: Additional file 5 of Transcriptome profile and immune infiltrated landscape revealed a novel role of γδT cells in mediating pyroptosis in celiac disease

description: Additional file 5: Table S2–S4. The GO, KEGG and Reactome analysis of DEGs between CeD and HC duodenal tissues in derivation cohort.
DOI: 10.6084/m9.figshare.23740604.v1
title: Additional file 6 of Transcriptome profile and immune infiltrated landscape revealed a novel role of γδT cells in mediating pyroptosis in celiac disease

description: Additional file 6: Table S5. Pyroptosis associated genes identified from the Reactome database, GO database, and previous reports.
DOI: 10.6084/m9.figshare.23740644.v1
title: Additional file 4 of Integrated analysis of lncRNA/circRNA–miRNA–mRNA in the proliferative phase of liver regeneration in mice with liver fibrosis

description: Additional file 4: Supplementary Table S4. DE mRNAs of each WGCNA modules.
DOI: 10.17632/jjkbg76srz.1
title: OES CUSN8ZN4PB1 sample 01

description: OES CUSN8ZN4PB1 sample 01
DOI: 10.6084/m9.figshare.23740638.v1
title: Additional file 2 of Integrated analysis of lncRNA/circRNA–miRNA–mRNA in the proliferative phase of liver regeneration in mice with liver fibrosis

description: Additional file 2: Supplementary Table S2. Summary of all lncRNAs, circRNAs, miRNAs, and mRNAs identified in this study.
DOI: 10.6084/m9.figshare.23740610
title: Additional file 8 of Transcriptome profile and immune infiltrated landscape revealed a novel role of γδT cells in mediating pyroptosis in celiac disease

description: Additional file 8: Table S7. The DEGs analysis between CeD and HC duodenal γδT cells.
DOI: 10.6084/m9.figshare.23740647.v1
title: Additional file 5 of Integrated analysis of lncRNA/circRNA–miRNA–mRNA in the proliferative phase of liver regeneration in mice with liver fibrosis

description: Additional file 5: Supplementary Table S5. miRNA-RNA targets predicted by Starbase.
DOI: 10.6084/m9.figshare.6963467
title: Additional file 8: of Characterization of kinase gene expression and splicing profile in prostate cancer with RNA-Seq data

description: Table S7. CDK5 isoform expression in two datasets. (XLSX 17 kb)
DOI: 10.6084/m9.figshare.6963449.v1
title: Additional file 7: of Characterization of kinase gene expression and splicing profile in prostate cancer with RNA-Seq data

description: Table S6. GO and KEGG enrichment analysis for DE and DS kinase genes. (XLSX 29 kb)
DOI: 10.5281/zenodo.10645188
title: Dataset generated and analyzed in the article "Future increases in soil moisture drought frequency at UK monitoring sites: merging the JULES land model with observations and convection-permitting UK Climate Projections"

description: This dataset contains:



Estimates of future and historical daily soil moisture values at 34 locations of the UK COsmic-ray Soil Moisture Observing System (COSMOS-UK) network (three netCDF files starting with "SM"). Each file is for one of the three time periods: 01 December 1980 - 29 November 2000, 01 December 2020 - 29 November 2040 and 01 December 2060 - 29 November 2080. Each file contains data for all 34 locations and 12 UKCP18 ensemble members.

Hourly bias-corrected Local (2.2 km) UK Climate Projections 2018 (UKCP18) data (three netCDF files starting with "UKCP18"). Each file is for one of the three time periods: 01 December 1980 - 30 November 2000, 01 December 2020 - 30 November 2040 and 01 December 2060 - 30 November 2080. Each file contains data for all 34 locations, 12 UKCP18 ensemble members and seven variables: specific humidity, precipitation, temperature, downward shortwave radiation, downward longwave radiation, wind speed and atmospheric pressure.

Coordinates of the 34 COSMOS-UK locations (csv file).

Vegetation information for the considered sites (docx file).


The soil moisture estimates are obtained by first optimising pedotransfer function parameters of the JULES land model and driving the model with bias-corrected 2.2 km UKCP18 data. This dataset was generated and analyzed in article: "Future increases in soil moisture drought frequency at UK monitoring sites: merging the JULES land model with observations and convection-permitting UK Climate Projections", by Magdalena Szczykulska, Chris Huntingford, Elizabeth Cooper and Jonathan G. Evans, which is to be submitted to Environmental Research Letters. Details are given in the above-mentioned article and the corresponding supplementary information.
DOI: 10.6084/m9.figshare.23740647
title: Additional file 5 of Integrated analysis of lncRNA/circRNA–miRNA–mRNA in the proliferative phase of liver regeneration in mice with liver fibrosis

description: Additional file 5: Supplementary Table S5. miRNA-RNA targets predicted by Starbase.
DOI: 10.6084/m9.figshare.23740650
title: Additional file 6 of Integrated analysis of lncRNA/circRNA–miRNA–mRNA in the proliferative phase of liver regeneration in mice with liver fibrosis

description: Additional file 6: Supplementary Table S6. miRNA-RNA targets predicted by miRanda.
DOI: 10.6084/m9.figshare.6963449
title: Additional file 7: of Characterization of kinase gene expression and splicing profile in prostate cancer with RNA-Seq data

description: Table S6. GO and KEGG enrichment analysis for DE and DS kinase genes. (XLSX 29 kb)