cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.6234953
title: Translation and cross-cultural adaptation of the Pediatric Confusion Assessment Method for the Intensive Care Unit into Brazilian Portuguese for the detection of delirium in pediatric intensive care units

description: ABSTRACT Objective: To undertake the translation and cross-cultural adaption into Brazilian Portuguese of the Pediatric Confusion Assessment Method for the Intensive Care Unit for the detection of delirium in pediatric intensive care units, including the algorithm and instructions. Methods: A universalist approach for the translation and cross-cultural adaptation of health measurement instruments was used. A group of pediatric critical care specialists assessed conceptual and item equivalences. Semantic equivalence was evaluated by means of a translation from English to Portuguese by two independent translators; reconciliation into a single version; back-translation by a native English speaker; and consensus among six experts with respect to language and content understanding by means of Likert scale responses and the Content Validity Index. Finally, operational equivalence was assessed by applying a pre-test to 30 patients. Results: The back-translation was approved by the original authors. The medians of the expert consensus responses varied between good and excellent, except for the feature "acute onset" of the instructions. Items with a low Content Validity Index for the features "acute onset" and "disorganized thinking" were adapted. In the pre-test, the expression "signal with your head" was modified into "nod your head" for better understanding. No further adjustments were necessary, resulting in the final version for Brazilian Portuguese. Conclusion: The Brazilian version of the Pediatric Confusion Assessment Method for the Intensive Care Unit was generated in agreement with the international recommendations and can be used in Brazil for the diagnosis of delirium in critically ill children 5 years of age or above and with no developmental cognitive disabilities.
DOI: 10.6084/m9.figshare.6234956.v1
title: Antifungal and antioxidant activities of mature leaves of Myrcia splendens (Sw.) DC.

description: Abstract In recent years, natural products with antifungal and antioxidant activities are being increasingly researched for a more sustainable alternative to the chemicals currently used for the same purpose. The plant pathogenic fungus Alternaria alternata is a causative agent of diseases in citrus, leading to huge economic losses. Antioxidants are important for the production of medicines for various diseases that may be related to the presence of free radicals, such as cancer, and in the cosmetic industry as an anti-aging agent and the food industry as preservatives. This study evaluated the antifungal and antioxidant potential of extracts of mature leaves of Myrcia splendens, a tree species that occurs in the Brazilian Cerrado. The antioxidant potential was analyzed by an assay of 1,1-diphenyl-2-picrylhydrazyl radical-scavenging method, and the antifungal activity was assessed through the evaluation of mycelial growth. Majority of the extracts exhibited a strong antioxidant activity, especially the acetonic extract (4A). The antioxidant activity may be related to the presence of phenolic compounds. However, the extracts showed no inhibitory activity of mycelial growth of the fungus tested, with the exception of dichloromethanic extract (2B), which had an inhibitory effect (10.2%) at the end of testing.
DOI: 10.6084/m9.figshare.6234953.v1
title: Translation and cross-cultural adaptation of the Pediatric Confusion Assessment Method for the Intensive Care Unit into Brazilian Portuguese for the detection of delirium in pediatric intensive care units

description: ABSTRACT Objective: To undertake the translation and cross-cultural adaption into Brazilian Portuguese of the Pediatric Confusion Assessment Method for the Intensive Care Unit for the detection of delirium in pediatric intensive care units, including the algorithm and instructions. Methods: A universalist approach for the translation and cross-cultural adaptation of health measurement instruments was used. A group of pediatric critical care specialists assessed conceptual and item equivalences. Semantic equivalence was evaluated by means of a translation from English to Portuguese by two independent translators; reconciliation into a single version; back-translation by a native English speaker; and consensus among six experts with respect to language and content understanding by means of Likert scale responses and the Content Validity Index. Finally, operational equivalence was assessed by applying a pre-test to 30 patients. Results: The back-translation was approved by the original authors. The medians of the expert consensus responses varied between good and excellent, except for the feature "acute onset" of the instructions. Items with a low Content Validity Index for the features "acute onset" and "disorganized thinking" were adapted. In the pre-test, the expression "signal with your head" was modified into "nod your head" for better understanding. No further adjustments were necessary, resulting in the final version for Brazilian Portuguese. Conclusion: The Brazilian version of the Pediatric Confusion Assessment Method for the Intensive Care Unit was generated in agreement with the international recommendations and can be used in Brazil for the diagnosis of delirium in critically ill children 5 years of age or above and with no developmental cognitive disabilities.
DOI: 10.6084/m9.figshare.6234950
title: The mid-level bureaucrats’ performance: determinants of their activities and work relationships

description: Abstract Although scholars have been investigating bureaucrats for a long time, mid-level bureaucrats (MLB) have been far less studied in the literature. To fill this gap, this article explores MLBs heterogeneity regarding their profile, professional background and, above all, performance. The main goal is to investigate the determinants of bureaucrats’ performance, depicted by two crucial dimensions: the degree of MLBs relationship within public bureaucracy and complexity level of their activities. These skills are valued today with increasing importance in contexts of network governance and bureaucratic responsiveness. First, a descriptive analysis was undertaken of survey data collected in 2014 from federal mid-level bureaucrats in positions filled by appointment. This was followed by formulating synthetic indexes of two dimensions: bureaucrats’ activities and their work relationships. Subsequently, multivariate models were employed to explain the determinants of these dimensions. Empirical results show that the mid-level bureaucrats’ performance is both affected by the government’s structure factors as well as by their own individual characteristics. However, the variables effects vary considerably. The empirical evidence suggests that MLBs tend to be more connected and perform more activities as they hold higher positions filled by appointment, have a higher level of education and capacity to influence decision processes and work directly with policymaking, especially in social policy.
DOI: 10.6084/m9.figshare.6234950.v1
title: The mid-level bureaucrats’ performance: determinants of their activities and work relationships

description: Abstract Although scholars have been investigating bureaucrats for a long time, mid-level bureaucrats (MLB) have been far less studied in the literature. To fill this gap, this article explores MLBs heterogeneity regarding their profile, professional background and, above all, performance. The main goal is to investigate the determinants of bureaucrats’ performance, depicted by two crucial dimensions: the degree of MLBs relationship within public bureaucracy and complexity level of their activities. These skills are valued today with increasing importance in contexts of network governance and bureaucratic responsiveness. First, a descriptive analysis was undertaken of survey data collected in 2014 from federal mid-level bureaucrats in positions filled by appointment. This was followed by formulating synthetic indexes of two dimensions: bureaucrats’ activities and their work relationships. Subsequently, multivariate models were employed to explain the determinants of these dimensions. Empirical results show that the mid-level bureaucrats’ performance is both affected by the government’s structure factors as well as by their own individual characteristics. However, the variables effects vary considerably. The empirical evidence suggests that MLBs tend to be more connected and perform more activities as they hold higher positions filled by appointment, have a higher level of education and capacity to influence decision processes and work directly with policymaking, especially in social policy.
DOI: 10.6084/m9.figshare.6234947
title: Electrodeposition of Prussian Blue/Carbon Nanotube Composites at a Liquid-Liquid Interface

description: The iron complex hexacyanoferrate (Fe4[Fe(CN)6]3), known as Prussian Blue (PB), was electrodeposited over a free-standing carbon nanotube (CNT) film assembled at the interface between two immiscible liquids, water and 1,2-dichlorobenzene. Polarization of the interface achieved through a fixed potential or under potential variation enabled iron present inside CNTs to generate a stable CNT/PB composite. We report herein on the observation that the deposition of PB is dependent on both the pH and applied potential. It was found that aqueous phases containing K3[Fe(CN)6] can decompose under an applied potential, while those containing K4[Fe(CN)6] presented more stable behavior making it a suitable precursor for PB synthesis. The electrodeposition and modification of the interface was followed by in situ spectroelectrochemical Raman spectroscopy, which indicated that an increase in signal due to PB formation was acompanied by changes in the CNT bands due to modification of the CNT walls by decoration with PB, forming a composite structure.
DOI: 10.6084/m9.figshare.6234947.v1
title: Electrodeposition of Prussian Blue/Carbon Nanotube Composites at a Liquid-Liquid Interface

description: The iron complex hexacyanoferrate (Fe4[Fe(CN)6]3), known as Prussian Blue (PB), was electrodeposited over a free-standing carbon nanotube (CNT) film assembled at the interface between two immiscible liquids, water and 1,2-dichlorobenzene. Polarization of the interface achieved through a fixed potential or under potential variation enabled iron present inside CNTs to generate a stable CNT/PB composite. We report herein on the observation that the deposition of PB is dependent on both the pH and applied potential. It was found that aqueous phases containing K3[Fe(CN)6] can decompose under an applied potential, while those containing K4[Fe(CN)6] presented more stable behavior making it a suitable precursor for PB synthesis. The electrodeposition and modification of the interface was followed by in situ spectroelectrochemical Raman spectroscopy, which indicated that an increase in signal due to PB formation was acompanied by changes in the CNT bands due to modification of the CNT walls by decoration with PB, forming a composite structure.
DOI: 10.6084/m9.figshare.6234944
title: Ditryptophan Cross-Links as Novel Products of Protein Oxidation

description: Protein oxidation is an unavoidable consequence of aerobic metabolism. The oxidation of most proteins residues is non-repairable and may affect protein structure and function. In particular, protein cross-links arising from oxidative modifications are presumably toxic to cells because they may accumulate and induce protein aggregation. However, most of these irreversible protein cross-links remain partially characterized. Up to very recently, ditryptophan cross-links (Trp-Trp), in particular, have been largely disregarded in the literature. Here, we briefly review studies showing that Trp-Trp cross-links can be formed in proteins exposed to a variety of oxidants. The challenges to fully characterize Trp-Trp cross-links are discussed as well as their potential roles in protein dysfunction and aggregation.
DOI: 10.6084/m9.figshare.6234938
title: Rationalities in motivation for citizen participation in social accountability: a Brazilian local experience

description: Abstract This work aims to understand the motivation and factors that influence active participation in social accountability, contributing to literature on public administration in a field which is not fully explored. This study provides elements to help public actors to strengthen initiatives of citizens’ engagement in public management, especially by working with civil society organizations. The main theoretical approaches are the instrumental and the substantive rationality in public organizations, as well as the motivation for citizen participation. Information was collected through in-depth interviews. Content analysis was used to examine the information, allowing to achieve the objectives of the study. The main results indicate the complementarity of both instrumental and substantive rationality in motivating citizen participation in initiatives of social accountability. The motivation to participate comes from the value given to social accountability, which is related to substantive rationality, while the instrumental rationality appears as a means of ensuring the efficiency and the effectiveness of citizens’ community actions.
DOI: 10.6084/m9.figshare.6234944.v1
title: Ditryptophan Cross-Links as Novel Products of Protein Oxidation

description: Protein oxidation is an unavoidable consequence of aerobic metabolism. The oxidation of most proteins residues is non-repairable and may affect protein structure and function. In particular, protein cross-links arising from oxidative modifications are presumably toxic to cells because they may accumulate and induce protein aggregation. However, most of these irreversible protein cross-links remain partially characterized. Up to very recently, ditryptophan cross-links (Trp-Trp), in particular, have been largely disregarded in the literature. Here, we briefly review studies showing that Trp-Trp cross-links can be formed in proteins exposed to a variety of oxidants. The challenges to fully characterize Trp-Trp cross-links are discussed as well as their potential roles in protein dysfunction and aggregation.
DOI: 10.6084/m9.figshare.6234935
title: Flow Analysis: Looking Back and Forward

description: Flow analysis changed significantly the way of performing chemical analysis by (i) mechanization of analytical procedures in a continuous flowing stream with minimal sample intercontamination; (ii) analytical measurements without attaining chemical equilibria, thus increasing the applicability of kinetic methods and allowing the exploitation of non-quantitative processes; (iii) exploitation of concentration gradients and (iv) use of unstable reagents or measurement of unstable products. Flow-based procedures are generally characterized by high sample throughput, improved precision, minimized waste generation, and often better selectivity. The performance of detection systems is usually improved because of the in-line sample conditioning and measurements under reproductive dynamic conditions and timing. However, after achieving several innovations, perspectives for further developments have been questioned mainly because of the recent decrease in the number of publications on flow analysis. The aim of this review is then to discuss the impact of flow-based methods on chemical analysis, emphasizing recent applications and developments, including miniaturization, bioanalysis, microextractions, green analytical chemistry and synergic hyphenation with other techniques and processes. The author's personal view about research perspectives in the field is also presented.
DOI: 10.6084/m9.figshare.6234938.v1
title: Rationalities in motivation for citizen participation in social accountability: a Brazilian local experience

description: Abstract This work aims to understand the motivation and factors that influence active participation in social accountability, contributing to literature on public administration in a field which is not fully explored. This study provides elements to help public actors to strengthen initiatives of citizens’ engagement in public management, especially by working with civil society organizations. The main theoretical approaches are the instrumental and the substantive rationality in public organizations, as well as the motivation for citizen participation. Information was collected through in-depth interviews. Content analysis was used to examine the information, allowing to achieve the objectives of the study. The main results indicate the complementarity of both instrumental and substantive rationality in motivating citizen participation in initiatives of social accountability. The motivation to participate comes from the value given to social accountability, which is related to substantive rationality, while the instrumental rationality appears as a means of ensuring the efficiency and the effectiveness of citizens’ community actions.
DOI: 10.6084/m9.figshare.6234935.v1
title: Flow Analysis: Looking Back and Forward

description: Flow analysis changed significantly the way of performing chemical analysis by (i) mechanization of analytical procedures in a continuous flowing stream with minimal sample intercontamination; (ii) analytical measurements without attaining chemical equilibria, thus increasing the applicability of kinetic methods and allowing the exploitation of non-quantitative processes; (iii) exploitation of concentration gradients and (iv) use of unstable reagents or measurement of unstable products. Flow-based procedures are generally characterized by high sample throughput, improved precision, minimized waste generation, and often better selectivity. The performance of detection systems is usually improved because of the in-line sample conditioning and measurements under reproductive dynamic conditions and timing. However, after achieving several innovations, perspectives for further developments have been questioned mainly because of the recent decrease in the number of publications on flow analysis. The aim of this review is then to discuss the impact of flow-based methods on chemical analysis, emphasizing recent applications and developments, including miniaturization, bioanalysis, microextractions, green analytical chemistry and synergic hyphenation with other techniques and processes. The author's personal view about research perspectives in the field is also presented.
DOI: 10.6084/m9.figshare.6234929
title: Scorpionism by Hemiscorpius spp. in Iran: a review

description: Abstract Scorpions are distributed throughout Iran and the genus Hemiscorpius is particularly important in this region. Hemiscorpius lepturus is the most significant species within the genus in the country. Since scorpionism provoked by Hemiscorpius comprises a medical emergency, the present study is focused on this important issue. In order to perform the present work, a review of the medical and health-related literature was carried out in several databases. The current findings indicate that six species of Hemiscorpius are found in 15 states of Iran, mainly in the south and southwest. Deaths caused by stings were reported only for two species. The morphological characteristics and geographical distribution of H. lepturus in Iran, its venom and the toxic compounds, epidemiologic data and clinical manifestations of envenomation as well as treatment for affected people are herein reviewed and described. H. lepturus venom toxicity differs from other Iranian scorpions regarding duration and severity. Scorpionism is an important public health problem in Iran, especially in southwest and south regions and in urban areas. It is more prevalent in children and young people. H. lepturus venom is primarily a cytotoxic agent and has hemolytic, nephrotoxic and to some extent hepatotoxic activity. The use of polyvalent antivenom to prevent scorpion sting symptoms is recommended. A well-planned health education program might be useful in preventing scorpionism.
DOI: 10.6084/m9.figshare.6234926
title: Application of indexes to assess the water quality of coastal basin of the Sapucaia in Sergipe

description: ABSTRACT The reduction of quali-quantitative availability of water in the world is directly related to the forms of land use and occupation, the productive processes of agriculture and cattle raising, the process of urbanization and the generation of domestic and industrial effluents. Thus, it is important to evaluate hydrographic basins regarding the use and occupation of their land and water quality as a tool for water management. This study aimed to characterize and monitor the quality of water of the Sapucaia Coastal Basin in the state of Sergipe, Brazil. The collections were performed quarterly in eight points of the basin, from August 2014 to September 2015. In the assessment of water quality, the Water Quality Index (WQI) and the Trophic State Index (TSI) were used. The analyzes of the samples were carried out according to the procedures outlined in Standard Methods; the following parameters were analyzed: total and fecal coliforms, turbidity, pH, dissolved oxygen, total solids, total phosphorus, total nitrogen, temperature, conductivity, biochemical oxygen demand and chlorophyll. The results from the application of the WQI classified water bodies as acceptable (2.5%), good (92.5%) and very good (5.0%). The results of the TSI ranked the samples as ultraoligotrophic (67.5%), oligotrophic (20.0%), mesotrophic (2.5%), eutrophic (7.5%) and supereutrophic (2.5%). The results allow to affirm that Aningas and Sapucaia rivers and Lagoa Redonda pond, belonging to the Sapucaia Coastal Basin, in Sergipe, have a low degree of degradation, with lower conservation of the sample point located in Sapucaia river, within the Reserva Santa Isabel reserve, that being a widely visited area on weekends and holidays.
DOI: 10.6084/m9.figshare.6234926.v1
title: Application of indexes to assess the water quality of coastal basin of the Sapucaia in Sergipe

description: ABSTRACT The reduction of quali-quantitative availability of water in the world is directly related to the forms of land use and occupation, the productive processes of agriculture and cattle raising, the process of urbanization and the generation of domestic and industrial effluents. Thus, it is important to evaluate hydrographic basins regarding the use and occupation of their land and water quality as a tool for water management. This study aimed to characterize and monitor the quality of water of the Sapucaia Coastal Basin in the state of Sergipe, Brazil. The collections were performed quarterly in eight points of the basin, from August 2014 to September 2015. In the assessment of water quality, the Water Quality Index (WQI) and the Trophic State Index (TSI) were used. The analyzes of the samples were carried out according to the procedures outlined in Standard Methods; the following parameters were analyzed: total and fecal coliforms, turbidity, pH, dissolved oxygen, total solids, total phosphorus, total nitrogen, temperature, conductivity, biochemical oxygen demand and chlorophyll. The results from the application of the WQI classified water bodies as acceptable (2.5%), good (92.5%) and very good (5.0%). The results of the TSI ranked the samples as ultraoligotrophic (67.5%), oligotrophic (20.0%), mesotrophic (2.5%), eutrophic (7.5%) and supereutrophic (2.5%). The results allow to affirm that Aningas and Sapucaia rivers and Lagoa Redonda pond, belonging to the Sapucaia Coastal Basin, in Sergipe, have a low degree of degradation, with lower conservation of the sample point located in Sapucaia river, within the Reserva Santa Isabel reserve, that being a widely visited area on weekends and holidays.