cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.3535/x6k-5fn-cxv
title: sedimentary rocks

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/bvy-q2p-tty
title: sedimentary rocks

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/n5g-pxx-rpy
title: sedimentary rocks

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/ng6-0ek-0z9
title: sedimentary rocks

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/ze5-p02-dbj
title: sedimentary rocks

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/062-s2c-lxz
title: sedimentary rocks

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/sw4-xr6-k6x
title: carbonate rocks

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/gcj-0km-8nl
title: sedimentary rocks

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/hlh-y5t-yal
title: sedimentary rocks

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.25345/c5wm1460h
title: MassIVE MSV000097484 - Hepatocellular Metabolic Profile: Understanding Post-Thawing Metabolic Shift in Primary Hepatocytes in vitro
title: Positive and negative-mode metabolomics data from a time-course experiment for unexposed cells during a 24-hour time course, investigating the changes in metabolism of primary human hepatocytes in vitro post-thawing.
DOI: 10.3535/382-2y8-6s3
title: sedimentary rocks

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/6gk-abh-gf4
title: Calcite

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/ff0-h4v-kxg
title: sedimentary rocks

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/v0n-bvc-sn7
title: Platycladus Spach

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/jn7-kp1-vg4
title: Graptolithina Bronn, 1849

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/rfw-j8e-f9f
title: carbonate rocks

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/zqa-6ek-hbw
title: igneous rocks

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/eak-l6g-e43
title: carbonate rocks

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/zdw-4d1-khm
title: Pyrite

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/enb-20g-k3p
title: sedimentary rocks

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/rmh-ayh-c2r
title: carbonate rocks

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.15468/dl.9ypgk9
title: Occurrence Download

description: A dataset listing the 4054222 species recorded in GBIF matching the query:
{
 "OccurrenceStatus" : [
 "is Present"
 ]
}

 The dataset's 4054222 records were derived from 72044 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0011021-250325103851331/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.3535/a28-g7f-zxr
title: Platycladus Spach

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/tn5-tx3-bzw
title: Platycladus Spach

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/249-3pe-33c
title: Platycladus Spach

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/rp8-xxz-kcw
title: Platycladus Spach

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/0ll-ptg-0vh
title: Platycladus Spach

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/4j9-pnw-nlg
title: Platycladus Spach

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/tsa-1vr-sfx
title: Platycladus Spach

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/yad-8zb-tl8
title: sedimentary rocks

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/chn-aax-j3b
title: Conochitina capitata Eisenack, 1962

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/tkk-tmj-axx
title: Platycladus Spach

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/5k3-dck-957
title: sedimentary rocks

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/yvl-6w9-anx
title: sedimentary rocks

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.5281/zenodo.14019667
title: Deciphering KPC Variant Resistance: Cross-Resistance Mechanisms to Last-Resort Antibiotics

description: Klebsiella pneumoniae carbapenemase (KPC) variants, predominantly KPC-2 and KPC-3, are a significant global resistance mechanism in K. pneumoniae. KPC-2 and KPC-3 confer resistance to a broad range of β-lactams, including carbapenems, while remaining susceptible to ceftazidime-avibactam (CZA). Lately, new KPC variants have emerged and developed resistance to CZA, often through mutations, insertions, or deletions in key regions such as the Omega loop, the 237–243 loop, and the 266–275 loop. In the present work we aim to understand the role of these mutations in KPC in the emergence of cross-resistance to last-resort antibiotics like cefiderocol (FDC) and cefepime/zidebactam (FPZ). Fifteen clinical isolates of KPC-producing Klebsiella spp. were analyzed, representing 15 distinct KPC variants. CZA resistance was confirmed in 12 of the 15 KPC variants tested. Cross-resistance to FDC was observed in eight isolates, with five of these exhibiting spontaneous resistant subpopulations, including one originally categorized as FDC-susceptible. Six FDC-resistant strains carried mutations in the 266–275 loop. Cross-resistance to FPZ was observed in five KPC variants, particularly those with mutations in the 266–275 loop, although many omega loop and 237–243 loop mutants remained susceptible to FPZ. WGS of FDC-resistant subpopulations revealed additional mutations in genes such as ompC, rpoC, dksA, and cirA.This study demonstrates that KPC variants show resistance to both CZA and FDC, with cross-resistance to FPZ observed to a lesser degree. The emergence of cross-resistance in strains that had not been exposed to these antibiotics raises concerns about the spread of resistance. The identification of mutations in blaKPC, cirA, and other novel genes highlights the importance of understanding the molecular mechanisms driving resistance to develop effective therapeutic strategies.
description: Files Description

---rawseqs_ref.tar.gz: FASTQ file of wild type strains

---annot_assemblies_ref.tar.gz: FASTA files of wild-type strains. Genome annotation files of wild-type strains

---IHC_seqs.tar.gz: FASTQ files of IHC strains

--- annot_IHC.tar.gz: Genome annotation files of IHC strains

--- assemblies_IHC.tar.gz: FASTA files of IHC strains.
DOI: 10.3535/45a-9fg-54t
title: sedimentary rocks

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/vpy-lsl-cvn
title: sedimentary rocks

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.5281/zenodo.14019666
title: Emerging Resistance to Novel b-Lactam b-Lactamase Inhibitor Combinations in Klebsiella pneumoniae bearing KPC Variants

description: Klebsiella pneumoniae carbapenemase (KPC) variants, predominantly KPC-2 and KPC-3, are a significant global resistance mechanism in K. pneumoniae. KPC-2 and KPC-3 confer resistance to a broad range of β-lactams, including carbapenems, while remaining susceptible to ceftazidime-avibactam (CZA). Lately, new KPC variants have emerged and developed resistance to CZA, often through mutations, insertions, or deletions in key regions such as the Omega loop, the 237–243 loop, and the 266–275 loop. In the present work we aim to understand the role of these mutations in KPC in the emergence of cross-resistance to last-resort antibiotics like cefiderocol (FDC) and cefepime/zidebactam (FPZ). Fifteen clinical isolates of KPC-producing Klebsiella spp. were analyzed, representing 15 distinct KPC variants. CZA resistance was confirmed in 12 of the 15 KPC variants tested. Cross-resistance to FDC was observed in eight isolates, with five of these exhibiting spontaneous resistant subpopulations, including one originally categorized as FDC-susceptible. Six FDC-resistant strains carried mutations in the 266–275 loop. Cross-resistance to FPZ was observed in five KPC variants, particularly those with mutations in the 266–275 loop, although many omega loop and 237–243 loop mutants remained susceptible to FPZ. WGS of FDC-resistant subpopulations revealed additional mutations in genes such as ompC, rpoC, dksA, and cirA.This study demonstrates that KPC variants show resistance to both CZA and FDC, with cross-resistance to FPZ observed to a lesser degree. The emergence of cross-resistance in strains that had not been exposed to these antibiotics raises concerns about the spread of resistance. The identification of mutations in blaKPC, cirA, and other novel genes highlights the importance of understanding the molecular mechanisms driving resistance to develop effective therapeutic strategies.
description: Files Description

---rawseqs_ref.tar.gz: FASTQ file of wild type strains

---annot_assemblies_ref.tar.gz: FASTA files of wild-type strains. Genome annotation files of wild-type strains

---IHC_seqs.tar.gz: FASTQ files of IHC strains

--- annot_IHC.tar.gz: Genome annotation files of IHC strains

--- assemblies_IHC.tar.gz: FASTA files of IHC strains.
DOI: 10.5281/zenodo.15122353
title: Emerging Resistance to Novel b-Lactam b-Lactamase Inhibitor Combinations in Klebsiella pneumoniae bearing KPC Variants

description: Klebsiella pneumoniae carbapenemase (KPC) variants, predominantly KPC-2 and KPC-3, are a significant global resistance mechanism in K. pneumoniae. KPC-2 and KPC-3 confer resistance to a broad range of β-lactams, including carbapenems, while remaining susceptible to ceftazidime-avibactam (CZA). Lately, new KPC variants have emerged and developed resistance to CZA, often through mutations, insertions, or deletions in key regions such as the Omega loop, the 237–243 loop, and the 266–275 loop. In the present work we aim to understand the role of these mutations in KPC in the emergence of cross-resistance to last-resort antibiotics like cefiderocol (FDC) and cefepime/zidebactam (FPZ). Fifteen clinical isolates of KPC-producing Klebsiella spp. were analyzed, representing 15 distinct KPC variants. CZA resistance was confirmed in 12 of the 15 KPC variants tested. Cross-resistance to FDC was observed in eight isolates, with five of these exhibiting spontaneous resistant subpopulations, including one originally categorized as FDC-susceptible. Six FDC-resistant strains carried mutations in the 266–275 loop. Cross-resistance to FPZ was observed in five KPC variants, particularly those with mutations in the 266–275 loop, although many omega loop and 237–243 loop mutants remained susceptible to FPZ. WGS of FDC-resistant subpopulations revealed additional mutations in genes such as ompC, rpoC, dksA, and cirA.This study demonstrates that KPC variants show resistance to both CZA and FDC, with cross-resistance to FPZ observed to a lesser degree. The emergence of cross-resistance in strains that had not been exposed to these antibiotics raises concerns about the spread of resistance. The identification of mutations in blaKPC, cirA, and other novel genes highlights the importance of understanding the molecular mechanisms driving resistance to develop effective therapeutic strategies.
description: Files Description

---rawseqs_ref.tar.gz: FASTQ file of wild type strains

---annot_assemblies_ref.tar.gz: FASTA files of wild-type strains. Genome annotation files of wild-type strains

---IHC_seqs.tar.gz: FASTQ files of IHC strains

--- annot_IHC.tar.gz: Genome annotation files of IHC strains

--- assemblies_IHC.tar.gz: FASTA files of IHC strains.
DOI: 10.3535/6zc-tg1-pma
title: sedimentary rocks

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/xpq-0ej-wtg
title: sedimentary rocks

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/7zb-de8-aj5
title: limestone

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/f20-m62-jjn
title: sedimentary rocks

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/2ed-9cl-r2t
title: Platycladus Spach

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/vac-xxv-x29
title: sedimentary rocks

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/dkc-09s-p2e
title: sedimentary rocks

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/dzp-4va-9ez
title: siliciclastic rocks

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/399-lwy-pjp
title: sedimentary rocks

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/gbe-yf2-h1b
title: Dictyonema

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/2be-qam-kbd
title: Brachiopoda Duméril, 1805

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/wel-yf6-ntd
title: Platycladus Spach

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/3z6-4qr-kpk
title: Platycladus Spach

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/s9g-9xf-nry
title: Platycladus Spach

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/4t5-2kb-21l
title: limestone

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/tdc-ywd-96f
title: carbonate rocks

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/n6b-t7n-7lc
title: carbonate rocks

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/p46-5nv-pbf
title: carbonate rocks

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/0aq-qg1-4ns
title: sedimentary rocks

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/eqe-9pz-eag
title: limestone

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/6b4-eja-07v
title: sedimentary rocks

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/s8h-27f-fft
title: limestone

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/1jy-wmf-lnr
title: carbonate rocks

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/l5n-qzz-nm6
title: igneous- and metamorphic rocks

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/6g4-fsm-vag
title: Platycladus Spach

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/qw3-k8h-sr8
title: sedimentary rocks

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/711-7jp-waz
title: sedimentary rocks

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/a29-rr2-vfx
title: sedimentary rocks

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/qxa-qdp-3pb
title: Platycladus Spach

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/s0m-qyb-g75
title: Platycladus Spach

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/52m-wqw-e59
title: rocks

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/n45-c4k-t2q
title: sedimentary rocks

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/qn5-8xe-h7c
title: Platycladus Spach

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/z20-c2b-dk4
title: Platycladus Spach

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/t6e-bym-88w
title: sedimentary rocks

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/qlg-erj-rtl
title: carbonate rocks

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/2ft-j6p-0ac
title: sedimentary rocks

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/5ef-eye-j43
title: carbonate rocks

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/1kg-5hq-hz0
title: †Asaphidae

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/bgr-r2l-lyy
title: sedimentary rocks

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/6w3-26m-1yb
title: sedimentary rocks

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/leh-hm4-q6v
title: sedimentary rocks

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/9zv-lvc-x5x
title: sedimentary rocks

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/pnq-gnq-asf
title: sedimentary rocks

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/bts-yvg-5s5
title: carbonate rocks

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/qlt-jzz-zhn
title: sedimentary rocks

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/6af-b4m-p4l
title: sedimentary rocks

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/pfg-sr1-xsx
title: sedimentary rocks

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/0s0-v1c-t4d
title: sedimentary rocks

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/zg3-mx8-a4b
title: carbonate rocks

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/blx-5ze-nvq
title: sedimentary rocks

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/ph6-h3q-7zn
title: sedimentary rocks

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/649-8pr-24b
title: sedimentary rocks

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/ms1-81r-2af
title: sedimentary rocks

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/yz4-7y7-hbh
title: †Pterygometopidae

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/z7v-zs1-nr1
title: sedimentary rocks

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/70g-7m1-jhy
title: Brachiopoda Duméril, 1805

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/6ac-bdt-4zb
title: sedimentary rocks

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/9cp-pz9-vxx
title: sedimentary rocks

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/ymm-vnl-1l3
title: Leperditicopida

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/vl4-687-r3k
title: sedimentary rocks

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/zaa-qft-l3c
title: sedimentary rocks

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/3gq-adn-d33
title: sedimentary rocks

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/ysc-t07-81g
title: Platycladus Spach

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/fat-tbr-qss
title: metamorphic rocks

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/lf6-7cb-gjc
title: Calcite

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/jag-f4v-jz1
title: sedimentary rocks

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/js8-1tn-610
title: sedimentary rocks

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/tzk-ldj-38s
title: sedimentary rocks

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/6h9-zen-ct3
title: sedimentary rocks

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/nmy-05z-m47
title: sedimentary rocks

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/xhh-w32-3kl
title: sedimentary rocks

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/8mw-wvt-5pk
title: sedimentary rocks

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/bra-kgv-w3k
title: sedimentary rocks

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.