cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.5061/dryad.cm7pg
title: Data from: Hypoperfusion of the adventitial vasa vasorum develops an abdominal aortic aneurysm

description: The aortic wall is perfused by the adventitial vasa vasorum (VV). Tissue
 hypoxia has previously been observed as a manifestation of enlarged
 abdominal aortic aneurysms (AAAs). We sought to determine whether
 hypoperfusion of the adventitial VV could develop AAAs. We created a novel
 animal model of adventitial VV hypoperfusion with a combination of a
 polyurethane catheter insertion and a suture ligation of the infrarenal
 abdominal aorta in rats. VV hypoperfusion caused tissue hypoxia and
 developed infrarenal AAA, which had similar morphological and pathological
 characteristics to human AAA. In human AAA tissue, the adventitial VV were
 stenotic in both small AAAs (30–49 mm in diameter) and in large AAAs
 (&gt; 50 mm in diameter), with the sac tissue in these AAAs being
 ischemic and hypoxic. These results indicate that hypoperfusion of
 adventitial VV has critical effects on the development of infrarenal AAA.
description: AAA patient
 profile
DOI: 10.5061/dryad.5j3cc
title: Data from: Soil microbial species loss affects plant biomass and survival of an introduced bacterial strain, but not inducible plant defences

description: - Background and Aims: Plant growth-promoting rhizobacteria (PGPR) strains
 can influence plant-insect interactions. However, little is known about
 the effect of changes in the soil bacterial community in general and
 especially the loss of rare soil microbes on these interactions. Here, the
 influence of rare soil microbe-reduction on induced systemic resistance
 (ISR) in a wild ecotype of Arabidopsis thaliana against the aphid Myzus
 persicae was investigated. - Methods: To create a gradient of microbial
 abundances, soil was inoculated with a serial dilution of a microbial
 community and responses of Arabidopsis plants that originated from the
 same site as the soil microbes were tested. Plant biomass, transcription
 of genes involved in plant defences, and insect performance were measured.
 In addition, the effects of the PGPR strain Pseudomonas fluorescens SS101
 on plant and insect performance were tested under influence of the various
 soil dilution treatments. - Key Results: Plant biomass showed a
 hump-shaped relationship with soil microbial community dilution,
 independent of aphid or Pseudomonas treatments. Both aphid infestation and
 inoculation with Pseudomonas reduced plant biomass, and led to
 downregulation of PR1 (salicylic acid-responsive gene) and CYP79B3
 (involved in synthesis of glucosinolates). Aphid performance and gene
 transcription were unaffected by soil dilution. - Conclusions: Neither the
 loss of rare microbial species, as caused by soil dilution, nor
 Pseudomonas, affect the resistance of A. thaliana against M. persicae.
 However, both Pseudomonas survival and plant biomass respond to rare
 species loss. Thus, loss of rare soil microbial species can have a
 significant impact on both above- and belowground organisms.
description: Rare bacteria affect
 plant performance dataRaw data,
 ISR.xlsx
DOI: 10.6084/m9.figshare.30020767
title: Mannosylated chitosan-decorated PLGA nanoparticles for targeted pulmonary delivery of isoniazid: a promising approach in the treatment of tuberculosis

description: Tuberculosis (TB), caused by <i>Mycobacterium tuberculosis</i> (M. tb), represents a significant challenge to global health. The management of the disease requires an extended course of antibiotic therapy, spanning a duration of 6 to 9 months. The complexity and duration of these regimens frequently lead to significant adverse effects, gastrointestinal issues, and the development of drug resistance. To address these challenges, the nanoparticulate based inhalable drug delivery system was designed as such by synthesising mannosylated chitosan decorated PLGA nanoparticles loaded with isoniazid (MC-PLGA-INH-PNPs) for targeted pulmonary delivery. Hence, nanoparticle based drug delivery system offers the potential to target and deliver the loaded drug directly into the M.tb infected cells. The prepared and optimised nano-formulation had a particle size of 154.9 ± 21 nm, zeta potential −23.2 ± 0.52 mV and entrapment efficiency of 79.8% ± 0.45. Additionally, the MC-PLGA-INH-PNPs exhibited a sustained drug release profile at physiological pH 7.4 for a period of 24 hr. An <i>in vivo</i> study of the MC-PLGA-INH-PNPs was performed on a mouse model utilising lipopolysaccharide as an inducer. The data obtained from the <i>in vivo</i> studies showed substantial improvements in lung tissues architecture and reduced inflammation. The group of animals treated with the MC-PLGA-INH-PNPs showed significant improvement in restoration of the disease when compared to pure drug treated group. These findings further indicate that these inhalable MC-PLGA-INH-PNPs hold a promising strategy for the treatment of tuberculosis and considerably improves pulmonary drug delivery to the target site. However, detailed investigations and testing of this nano-formulation on other relevant animal models will be essential to successfully translate this concept from laboratory to clinical practice.
DOI: 10.6084/m9.figshare.30020767.v1
title: Mannosylated chitosan-decorated PLGA nanoparticles for targeted pulmonary delivery of Isoniazid: A promising approach in the treatment of Tuberculosis.

description: Tuberculosis (TB), caused by <i>Mycobacterium tuberculosis</i> (M. tb), represents a significant challenge to global health. The management of the disease requires an extended course of antibiotic therapy, spanning a duration of 6 to 9 months. The complexity and duration of these regimens frequently lead to significant adverse effects, gastrointestinal issues, and the development of drug resistance. To address these challenges, the nanoparticulate based inhalable drug delivery system was designed as such by synthesizing mannosylated chitosan decorated PLGA nanoparticles loaded with isoniazid (MC-PLGA-INH-PNPs) for targeted pulmonary delivery. Hence, nanoparticle based drug delivery system offers the potential to target and deliver the loaded drug directly into the M.tb infected cells. The prepared and optimized nano-formulation had a particle size of 154.9 ± 21 nm, zeta potential -23.2 ± 0.52 mV and entrapment efficiency of 79.8% ± 0.45. Additionally, the MC-PLGA-INH-PNPs exhibited a sustained drug release profile at physiological pH 7.4 for a period of 24 hr. An <i>in vivo</i> study of the MC-PLGA-INH-PNPs was performed on a mouse model utilizing lipopolysaccharide as an inducer. The data obtained from the <i>in vivo</i> studies showed substantial improvements in lung tissues architecture and reduced inflammation. The group of animals treated with the MC-PLGA-INH-PNPs showed significant improvement in restoration of the disease when compared to pure drug treated group. These findings further indicate that these inhalable MC-PLGA-INH-PNPs hold a promising strategy for the treatment of tuberculosis and considerably improves pulmonary drug delivery to the target site. However, detailed investigations and testing of this nano-formulation on other relevant animal models will be essential to successfully translate this concept from laboratory to clinical practice.
DOI: 10.6084/m9.figshare.30020767.v2
title: Mannosylated chitosan-decorated PLGA nanoparticles for targeted pulmonary delivery of isoniazid: a promising approach in the treatment of tuberculosis

description: Tuberculosis (TB), caused by <i>Mycobacterium tuberculosis</i> (M. tb), represents a significant challenge to global health. The management of the disease requires an extended course of antibiotic therapy, spanning a duration of 6 to 9 months. The complexity and duration of these regimens frequently lead to significant adverse effects, gastrointestinal issues, and the development of drug resistance. To address these challenges, the nanoparticulate based inhalable drug delivery system was designed as such by synthesising mannosylated chitosan decorated PLGA nanoparticles loaded with isoniazid (MC-PLGA-INH-PNPs) for targeted pulmonary delivery. Hence, nanoparticle based drug delivery system offers the potential to target and deliver the loaded drug directly into the M.tb infected cells. The prepared and optimised nano-formulation had a particle size of 154.9 ± 21 nm, zeta potential −23.2 ± 0.52 mV and entrapment efficiency of 79.8% ± 0.45. Additionally, the MC-PLGA-INH-PNPs exhibited a sustained drug release profile at physiological pH 7.4 for a period of 24 hr. An <i>in vivo</i> study of the MC-PLGA-INH-PNPs was performed on a mouse model utilising lipopolysaccharide as an inducer. The data obtained from the <i>in vivo</i> studies showed substantial improvements in lung tissues architecture and reduced inflammation. The group of animals treated with the MC-PLGA-INH-PNPs showed significant improvement in restoration of the disease when compared to pure drug treated group. These findings further indicate that these inhalable MC-PLGA-INH-PNPs hold a promising strategy for the treatment of tuberculosis and considerably improves pulmonary drug delivery to the target site. However, detailed investigations and testing of this nano-formulation on other relevant animal models will be essential to successfully translate this concept from laboratory to clinical practice.
DOI: 10.5061/dryad.3dt70
title: Data from: Habitat disturbance selects against both small and large species across varying climates

description: Global extinction drivers, including habitat disturbance and climate
 change, are thought to affect larger species more than smaller species.
 However, it is unclear if such drivers interact to affect assemblage body
 size distributions. We asked how these two key global change drivers
 differentially affect the interspecific size distributions of ants, one of
 the most abundant and ubiquitous animal groups on earth. We also asked
 whether there is evidence of synergistic interactions and whether effects
 are related to species’ trophic roles. We generated a global dataset on
 ant body size from 333 local ant assemblages collected by the authors
 across a broad range of climates and in disturbed and undisturbed
 habitats. We used head length (range: 0.22 – 4.55 mm) as a surrogate of
 body size and classified species to trophic groups. We used generalized
 linear models to test whether body size distributions changed with climate
 and disturbance, independent of species richness. Our analysis yielded
 three key results: 1) climate and disturbance showed independent
 associations with body size; 2) assemblages included more small species in
 warmer climates and fewer large species in wet climates; and 3) both the
 largest and smallest species were absent from disturbed ecosystems, with
 predators most affected in both cases. Our results indicate that
 temperature, precipitation and disturbance have differing effects on the
 body size distributions of local communities, with no evidence of
 synergistic interactions. Further, both large and small predators may be
 vulnerable to global change, particularly through habitat disturbance.
description: Gibb et al Ecography -
 DataData from 371 locations
 showing whole assemblage ant body size, including min, max, mean, variance
 and percentiles from 10th to 90th.
DOI: 10.5061/dryad.hr67c5p
title: Data from: Aggregation but not organo-metal complexes contributed to C storage in tidal freshwater wetland soils

description: One of the many goals of wetland restoration is to promote the long-term
 storage of carbon (C) in the terrestrial biosphere. Unfortunately, soil C
 reservoirs in restored wetlands are slow to accumulate even after
 hydrology and plant communities are reestablished. Oftentimes wetland
 restoration changes the soil matrix and thus can dramatically alter how
 soil C is stored and processed. Our research investigated whether soil
 organic matter (SOM) preservation theories derived from studies in
 non-wetland soil systems can be extended to wetland soils. We examined C
 associated with water-stable soil aggregates, minerals, and metal oxides
 within habitats of one natural and one restored tidal freshwater wetland.
 This study revealed that a majority of the soil C in the natural site was
 associated with large macroaggregates (&gt; 2000 μm), and soils from
 the restored site stored more C in small macroaggregates (&gt; 250 to
 &lt; 2000 μm). Despite these different associations, the chemical
 composition of SOM followed similar patterns across each aggregate-size
 class. Results from the sequential extraction procedure suggest
 organo-metal oxide complexes do not contribute to C stabilization in these
 habitats. This research is one of the few studies that have examined C
 stabilization related to soil structure in wetland soils. Our results
 suggest soil aggregate formation may be an important mechanism driving C
 stabilization, and that disruption to macroaggregates may limit C
 accumulation in restored wetlands. Additional empirical research and
 long-term field monitoring are needed to confirm linkages between
 aggregate-C stabilization and accumulation in wetland soils.
description: Compressed file with all
 dataThe compressed file
 contains six separate csv files for the tables and figures presented in
 this paper.Carbon.zip
DOI: 10.5061/dryad.7198505
title: Data from: Reproductive traits as predictors of assembly chronosequence patterns in epiphyllous bryophyte metacommunities

description: 1) Understanding the mechanisms underlying species assembly is a central
 focus of plant ecology and is crucial to revealing how plant communities
 are structured. However, the temporal limitations of most terrestrial
 plant communities preclude collection of species assembly data in a
 tractable time-frame. 2) The aim of this study is to investigate the
 importance of dispersal potential, as estimated by inter-specific
 variation in sexual and asexual expression, as a predictor of patch
 chronosequence assembly for epiphyllous (leaf-inhabiting) bryophytes.
 Secondarily, we investigate whether spatio-temporal patterns in patch
 turnover and compositional variation infer evidence of local
 (within-patch) population processes. The frequency and distribution of 55
 epiphyllous bryophytes across five leaf age classes were studied on an
 understory shrub Piper grande (Piperaceae) in pre-montane Panamanian
 tropical forest. Logistical models were used to test whether
 inter-specific variation in dispersal-related life history traits predicts
 assembly order. Beta diversity and ordination analyses were employed to
 examine nestedness versus turnover, and probe for repeatable patterns in
 patch chronosequence assembly, respectively. 3) Our results emphasize the
 importance of dispersal potential on species assembly patterns as earlier
 arrivals exhibit greater probabilities of sexual and specialized asexual
 expression. High turnover coupled with temporal convergence in species
 composition also point to evidence of within-patch biotic filtering. 4)
 Synthesis: Epiphylls are locally diverse in humid tropical forests
 worldwide; however, the mechanisms which maintain their high local
 diversity are unknown. This study suggests that inter-specific variation
 in dispersal capacity in combination with diffuse indirect effects are the
 principal contributors to the high alpha-diversity of these ephemeral
 metacommunities.
description: Sierra_etal_2018_Epiphyll_ChronosequenceCommunity dataset of epiphyll assembly on the host plant Piper grande. The dataset include presence/absence data, the representation index and sexual expression of epiphyllous species.
DOI: 10.5061/dryad.517jv
title: Data from: Habitat-mediated carry-over effects lead to context dependent outcomes of species interactions

description: 1. When individuals disperse, their performance in newly colonized
 habitats can be influenced by the conditions they experienced in the past,
 leading to environmental carry-over effects. While carry-over effects are
 ubiquitous in animal and plant systems, their impact on species
 interactions and coexistence are largely ignored in traditional
 coexistence theory. 2. Here we used a combination of modelling and
 experiments with two competing species to examine when and how such
 environmental carry-over effects influence community dynamics and
 competitive exclusions. 3. We found that variation in the natal habitat
 quality of colonizing individuals created carry-over effects which altered
 competitive coefficients, fecundity and mortality rates, and extinction
 probabilities of both species. As a consequence, the dynamics of
 competitive exclusion within and across habitat types was contingent on
 the natal habitat of colonizing individuals, indicating that spatial
 carry-over effects can fundamentally alter the dynamics and outcome of
 interspecific competition. 4. Interestingly, carry-over effects
 persistently influenced dynamics in systems with interspecific competition
 for the entire duration of the experiment while carry-over effects were
 transient and only influenced initial dynamics in single-species
 populations. Thus carry-over effects can be enhanced by species
 interactions, suggesting that their long-term effects may often not be
 accurately predicted by single-species studies. 5. Given that carry-over
 effects are ubiquitous in heterogeneous landscapes, our results provide a
 novel mechanism that could help explain variation in the structure of
 natural communities.
description: Final competition
 population time seriesPopulation counts across
 all samples for T. castaneum and T. confusum during the competition
 experiment. A key to the spreadsheet is included in the
 file.T castaneum control
 populationsPopulation counts for T.
 castaneum during the single species experiment.T confusum control
 populationsPopulation counts across
 all samples for the T. confusum single species
 experiment.
DOI: 10.5061/dryad.q2kg1
title: Data from: Accuracy and readability of cardiovascular entries on Wikipedia: are they reliable learning resources for medical students?

description: Objective: To evaluate accuracy of content and readability level of
 English Wikipedia articles on cardiovascular diseases, using quality and
 readability tools. Methods: Wikipedia was searched on the 6 October 2013
 for articles on cardiovascular diseases. Using a modified DISCERN (DISCERN
 is an instrument widely used in assessing online resources), articles were
 independently scored by three assessors. The readability was calculated
 using Flesch-Kincaid Grade Level. The inter-rater agreement between
 evaluators was calculated using the Fleiss κ scale. Results: This study
 was based on 47 English Wikipedia entries on cardiovascular diseases. The
 DISCERN scores had a median=33 (IQR=6). Four articles (8.5%) were of good
 quality (DISCERN score 40–50), 39 (83%) moderate (DISCERN 30–39) and 4
 (8.5%) were poor (DISCERN 10–29). Although the entries covered the
 aetiology and the clinical picture, there were deficiencies in the
 pathophysiology of diseases, signs and symptoms, diagnostic approaches and
 treatment. The number of references varied from 1 to 127 references;
 25.9±29.4 (mean±SD). Several problems were identified in the list of
 references and citations made in the articles. The readability of articles
 was 14.3±1.7 (mean±SD); consistent with the readability level for college
 students. In comparison, Harrison’s Principles of Internal Medicine 18th
 edition had more tables, less references and no significant difference in
 number of graphs, images, illustrations or readability level. The overall
 agreement between the evaluators was good (Fleiss κ 0.718 (95% CI 0.57 to
 0.83). Conclusions: The Wikipedia entries are not aimed at a medical
 audience and should not be used as a substitute to recommended medical
 resources. Course designers and students should be aware that Wikipedia
 entries on cardiovascular diseases lack accuracy, predominantly due to
 errors of omission. Further improvement of the Wikipedia content of
 cardiovascular entries would be needed before they could be considered a
 supplementary resource.
description: Suppl Material 1 Azer:
 Characteristics of Wikipedia cardiovascular topics, DISCERN scores and
 readability scores.This document shows the
 characteristics of the Wikipedia cardiovascular topics included in the
 study, the DISCERN scores obtained from three evaluators and the
 readability scores.Suppl Material 1
 Azer.pdfSuppl Material 2 Azer:
 Assessment of the corresponding cardiovascular topics in Harrison’s
 Principles of Internal Medicine, 18th EditionAssessment of the
 corresponding cardiovascular topics in the Harrison’s Principles of
 Internal Medicine, 18th Edition in regard to number of images,
 illustrations, graphs, tables, references (as per the textbook and the CD
 provided with the book, Access Medicine) and readability scores of each
 topic.Suppl
 Material 2 Azer.pdf
DOI: 10.5061/dryad.8v96r
title: Data from: Costs of reproduction explain the correlated evolution of semelparity and egg size: theory and a test with salmon

description: Species’ life history traits, including maturation age, number of
 reproductive bouts, offspring size and number, reflect adaptations to
 diverse biotic and abiotic selection pressures. A striking example of
 divergent life histories is the evolution of either iteroparity (breeding
 multiple times) or semelparity (breed once and die). We analysed published
 data on salmonid fishes and found that semelparous species produce larger
 eggs, that egg size and number increase with salmonid body size among
 populations and species and that migratory behaviour and parity interact.
 We developed three hypotheses that might explain the patterns in our data
 and evaluated them in a stage-structured modelling framework accounting
 for different growth and survival scenarios. Our models predict the
 observation of small eggs in iteroparous species when egg size is costly
 to maternal survival or egg number is constrained. By exploring trait
 co-variation in salmonids, we generate new hypotheses for the evolution of
 trade-offs among life history traits.
description: Salmonid life history
 data from published literatureThis is a compilation of
 published values of salmonid egg sizes, fecundity, body size, age at
 maturity, and GSI for 14 species.Kindsvater et al. SI Data Table
 1.xlsx
DOI: 10.15468/dl.umv2zh
title: Occurrence Download

description: A dataset containing 10651533 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Decapoda",
 "HasCoordinate is TRUE",
 "OccurrenceStatus is Present"
 ]
}

 The dataset includes 10651533 records from 3754 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0000853-260126135527185/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.17632/zyjcvb46t6.1
title: Experimental characterization of multi-pathway diffusion of lithium in feldspar

description: Supplementary data for the manuscript, "Experimental characterization of multi-pathway diffusion of lithium in feldspar" submitted to Geochimica Cosmochimica et Acta. The attached XLS files include the EPMA data for the starting compositions of the feldspars used in experiments, and the processed LA-ICP-MS data for each experiment.