cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.4231/65gz-k658
title: Data and code from: Locomotion control during curb descent: Bilateral ground reaction variables covary consistently during the double support phase regardless of future foot placement constraints

description: &lt;p&gt;During community ambulation, anticipatory adaptations in gait are key for navigating built, populated and natural environments. While stability or balance is critical while walking, some instability can assist in situations that demand maneuverability. Our goal was to identify whether healthy young individuals exhibit signs of such instability (or reduced stability) when they anticipate an upcoming maneuver. &lt;/p&gt;

&lt;p&gt;Participants approached and stepped down from a curb, and in different experimental conditions, they were required to step onto visual targets on the floor for the step after stepping down from the curb. In some conditions, they expected the target to suddenly jump; this would require them to quickly adjust their gait to step onto the new target. &lt;/p&gt;

&lt;p&gt;We used force plates to measure the ground reaction forces under both feet when the participant stepped down from the curb (with the two legs at different heights), and a motion capture system to measure the kinematics of the two legs. We analyzed the data associated with stepping down to identify anticipatory changes in stability to assist in the target stepping required for the subsequent step. &lt;/p&gt;

&lt;p&gt;We computed stepping performance, and typical spatial-temporal gait variables (foot placements, step lengths and widths). We used the uncontrolled manifold analysis to determine whether the ground reaction forces under the two feet are coordinated to stabilize the motion of the body. Our main hypothesis was that the kinetic synergy indices, which quantify the stability, would be lower when the participants expect to change their movements to step on a target that might jump. &lt;/p&gt;

&lt;p&gt;In contrast to our expectations, we observed that the kinetic synergy indices during curb descent were minimally influenced by expected foot targeting maneuvers for the subsequent step. Only the resultant moment in the frontal plane showed reduced stability when targeting was required, but the synergy index was still high, indicating that the resultant moment was stable. Furthermore, the synergy indices indicated that the main function of the ground reaction variables is to maintain stability of whole-body rotations during double support, and this prerogative was minimally influenced by the subsequent foot targeting tasks, likely because the cost of losing balance while descending a curb would be higher than the cost of mis-stepping on a visual target. Our work demonstrates the salience of stabilizing body rotations during curb negotiation and improves our understanding of locomotor control in challenging environments.&lt;/p&gt;
description: Spatial-temporal variables, foot placements, and synergy indices that quantify the coordination between the ground reaction variables under both feet while stepping down from a curb. Code for generating figures from the data.
DOI: 10.25345/c5z60cg03
title: MassIVE MSV000100283 - Ketone body B-hydroxybutyrate restores Tau proteostasis via metabolism-independent mechanism
title: Alzheimers disease (AD) and related tauopathies are marked by brain accumulation of pathological Tau aggregates and associated metabolic dysfunction. Metabolic interventions including ketogenic diets, caloric restriction, and exercise have shown promise in ameliorating cognitive impairments in AD, but variable efficacy and issues of compliance and side effects mar their translational potential. A shared molecular feature between these interventions is the induction of ketosis, a metabolic state marked by elevated circulating levels of beta hydroxybutyrate (BHB). Previous studies show BHB administration directly or in the form of a precursor can reproduce and even improve upon the benefits of metabolic interventions, but the molecular mechanism underlying the neuroprotective properties of BHB in AD remains to be elucidated. In the current study, we find that a BHB precursor diet is sufficient to ameliorate Tau pathophysiology in the PS19 mouse model at both the pathological and single-cell levels. Furthermore, using a wide array of in vitro, ex vivo, and in vivo models and the non-canonical enantiomer of BHB, we find that not only does BHB improve Tau proteostasis and reduce Tau aggregation and propagation, but the metabolism of BHB is dispensable to these effects. These data support an alternative model to one widely accepted by the field, that BHB exerts its benefits through the provision of alternative energy, uncovering novel biology of metabolic interventions and positioning the metabolic-independent features of BHB as new therapeutic avenues in neurodegenerative disorders.
DOI: 10.4231/pd9d-2b91
title: ACTH and Control Injection Data (WBC differential count, serum corticosterone and cortisol concentrations) for 6, 17, and 26 WOA Pullets

description: &lt;p&gt;The avian stress pathway is poorly understood but activation of the hypothalamic-pituitary-adrenal (&lt;strong&gt;HPA&lt;/strong&gt;) axis through an internal stressor like adrenocorticotropic hormone (&lt;strong&gt;ACTH&lt;/strong&gt;) administration generally results in elevations of glucocorticoids like corticosterone and cortisol in the blood. Additionally, white blood cell populations can be altered. Specifically, the heterophil:lymphocyte (H:L) ratio is often elevated during periods of stress. However, in wild birds the stress pathway is often down-regulated early in life. A few chicken studies found the opposite result where the stress pathway was up-regulated in early development.&lt;/p&gt;

&lt;p&gt;In order to evaluate age effects of stress pathway activation in laying hens, ten each of Lohmann LSL-Lite hens received either a saline-mannitol or synthetic human ACTH injection at 6, 17, and 26 weeks of age. Prior to injections as well as one and two hours post-injection, blood was collected and WBC differential counts and H:L ratios were determined by a boarded clinical pathologist (N=10/treatment). Serum corticosterone and cortisol levels were measured using a liquid chromatography (&lt;strong&gt;LC&lt;/strong&gt;) system coupled to a mass spectrometer (MS/MS) (N=5/treatment). At 26 weeks of age, egg albumen samples were collected and corticosterone and cortisol were measured using a liquid chromatography (&lt;strong&gt;LC&lt;/strong&gt;) system coupled to a mass spectrometer (MS/MS) (N=5/treatment).&lt;/p&gt;

&lt;p&gt;Plasma corticosterone was unaffected by treatment and egg albumen corticosterone and cortisol were below detectable limits at all time points for both treatments. Serum cortisol increased 1 hour after injection in the ACTH group at all ages, this was significant at 17 WOA (P&lt;0.0001). The H:L ratio was not affected by treatment but heterophils increased and lymphocytes decreased in the ACTH group compared to the control group, this difference was only significant at 26 WOA (P&lt;0.0004).&lt;/p&gt;

&lt;p&gt;The results of this study suggest that the H:L ratio is not an accurate measure of acute HPA axis activation during the pullet phase and that plasma corticosterone and albumen corticosterone and cortisol are not accurate measures of acute HPA axis activation during the pullet or adult phases. Cortisol may have some utility in capturing a physiological stress response in pullets and adult hens.&lt;/p&gt;
description: Laying hen pullets were injected with an ACTH or saline solution at 6, 17, and 26 weeks of age. Serum corticosterone and cortisol as well as white blood cell (WBC) differential counts were collected. Injection times, doses, and comments are also...
DOI: 10.4231/fv42-tz12
title: Modeling carbon accumulation and greenhouse gas emissions of northern peatlands since the Holocene

description: &lt;p&gt;Northern peatlands are a large C stock and often act as a C sink, but are susceptible to climate warming. To understand the role of peatlands in the global carbon-climate feedback, it is necessary to accurately quantify their C stock changes and decomposition. In this study, a process-based model, the Peatland Terrestrial Ecosystem Model, is used to simulate pan-Arctic peatland C dynamics from 15ka BP to 1990. To improve the accuracy of the simulation, grid-specific water run-on and run-off processes were considered, four different pan-Arctic peatland distribution datasets were used, and a spatially-explicit peat basal date dataset was developed using a neural network approach. The model was calibrated against 2055 peat thickness observations and the parameters were interpolated to the pan-Arctic region. Using the model, we estimate that, in 1990, the pan-Arctic peatlands soil C stock is 396-421 Pg C, and the Holocene average C accumulation rate was 22.9 g C∙m&lt;sup&gt;-2&lt;/sup&gt; yr&lt;sup&gt;-1&lt;/sup&gt;. Our estimated peat permafrost development history generally agrees with multi-proxy-based paleo-climate datasets and core-derived permafrost areal dynamics. During 500 BP to 1990, the pan-Arctic region went through the Little Ice Age and Anthropocene warming. Under Anthropocene warming, in the freeze-thaw and permafrost-free regions, the peat C accumulation rate decreased, but it increased in permafrost regions. The project&#39;s outcome helps understanding the potential peatland responses to future climate changes.&lt;/p&gt;
description: This dataset is used to reproduce the results in Modeling carbon accumulation and greenhouse gas emissions of northern peatlands since the Holocene. The dataset includes simulated pan-Arctic peat thickness, soil C stock and historical permafrost...
DOI: 10.4231/j887-sn98
title: Data and Code from: Humans prioritize walking efficiency or walking stability based on environmental risk

description: &lt;p&gt;This work demonstrates how humans exploit the mechanics of their bodies to achieve specific movement goals. While this phenomenon is well-known in sports (e.g., modulation of body postures to increase jump height or length in high jump or long jump, or to control the number of twists and somersaults while diving), we demonstrate that the same principle is applicable in an activity of daily living &ndash; walking and stepping over an obstacle. Our results motivate the investigation of the effects of aging and pathology on this ability, and how any decrements could underlie mobility issues in these populations.&lt;/p&gt;

&lt;p&gt;Humans reuse the body&rsquo;s mechanical energy at the end of one step to achieve forward progression during the subsequent step, thereby reducing the energy required for walking. This is achieved by harnessing the passive instability of the upright human posture. Here we test the novel hypothesis that humans manipulate passive anterior-posterior (AP) stability by actively modulating the placement of each foot for each step to either achieve energy-efficient gait or to improve stability when balance is threatened.&lt;/p&gt;

&lt;p&gt;We computed the AP margin of stability, which quantifies the passive dynamic stability of gait, for multiple steps as healthy young adults (N=20) walked on a clear and on an obstructed walkway. Participants used passive dynamics to achieve energy-efficient gait for all but one step; when crossing the obstacle with the leading limb, AP margin of stability was increased and indicated cautious gait, reflecting the greater threat to balance arising from a potential trip. Furthermore, AP margin of stability increased while approaching the obstacle, indicating that humans proactively manipulated the passive dynamics to meet the demands of the locomotor task. Finally, the step length and the center of mass motion co-varied to maintain the AP margin of stability for all steps in both tasks at the specific values for each step. We conclude that humans actively regulate step length to maintain specific levels of passive stability for each step during unobstructed and obstructed gait.&lt;/p&gt;
description: Margin of stability (MOS) and MOS synergy indices that quantify coordination between the step length and the body's motion as healthy young adults approach and cross an obstacle. Code to generate figures from data.
DOI: 10.4231/szn1-nh50
title: Supplemental Material for Systematic Reviews on Human-Animal Interaction (HAI) Topics: A Look At Reporting Practices

description: lt;pgt;These documents are supplemental material for Jane Kinkus Yatcilla amp;amp; Kelly Weigandamp;#39;s manuscript amp;quot;Systematic Reviews on HAI Topics: A Look at Reporting Practices,amp;quot; as found at https://docs.lib.purdue.edu/lib_fsdocs/263/.lt;/pgt;

lt;pgt;The articles were discovered through the database search strategies listed in HAI-SRs-Search-Strategy.docx, duplicate records were removed, and then both authors screened each record for relevance to the project. A list of the 110 articles included in the analysis can be found in HAI-SRs-References-110.docx.lt;/pgt;
description: These files are supplemental material for the manuscript quot;Systematic Reviews on HAI Topics: A Look at Reporting Practicesquot; by Jane Kinkus Yatcilla and Kelly Weigand, which is available at https://docs.lib.purdue.edu/lib_fsdocs/263/.
DOI: 10.4231/e1ad-db33
title: The importance of interactions between snow, permafrost and vegetation dynamics in terrestrial carbon balance in circumpolar regions

description: &lt;p&gt;This project aims to quantify the snow and the canopy&#39;s influences on the carbon dynamics in circumpolar regions. We perform three sets of simulation. The model output reveals that the snow&#39;s warming effect will release more carbon into the atmosphere while the canopy&#39;s cooling effect will get carbon sequestered into the ecosystem.&lt;/p&gt;
description: This data contains model output of net primary production (NPP), heterotrophic respiration (RH), foliage projection cover (FPC) and soil temperature.
DOI: 10.4231/1yve-fw43
title: Data for: Simulations for x-ray imaging of wave-packet dynamics

description: &lt;p&gt;The data used to create the figures of this publication is contained, as well as plotting routines and the image files. The publication presents the results of simulations for imaging electronic wave-packet dynamics with x-ray scattering. The scattering patterns substantially deviate from that of the instantaneous momentum density of the electron wave-packet. We present several cases of scattering patterns and indicate the information contained therein. The patterns are proportional to the squared modulus of the wave-packet&#39;s Fourier transform weighted by the final state of the electron.&lt;/p&gt;
description: Data used in the figures of Phys. Rev. A 106, 033125 (2022) with short information in FILE_INFO.txt. Also contains .eps files and gnuplot routines.
DOI: 10.4231/2dem-z333
title: North Central Region Household Data (NCR-Stat): Baseline Survey

description: &lt;p pro="" sans="" source="" style="box-sizing: inherit; margin: 0px 0px 1.8em; padding: 0px; caret-color: rgb(80, 79, 81); color: rgb(80, 79, 81); font-family: "&gt;The NCR-Stat: Baseline Survey is the first of NCRCRD&rsquo;s regional household surveys and includes questions related to topics crucial for household and community development and wellbeing. All data gathered via the NCR-Stat Baseline Survey will be available for those who would like to use the data as a baseline for further research and extend the portfolio of already existing databases.&lt;/p&gt;

&lt;p pro="" sans="" source="" style="box-sizing: inherit; margin: 0px 0px 1.8em; padding: 0px; caret-color: rgb(80, 79, 81); color: rgb(80, 79, 81); font-family: "&gt;The NCR-Stat: Baseline Survey is a 20-minute survey designed to provide a baseline from a social and economic perspective. The survey focuses solely on households in the NCR states and asks questions about household demographics, income, workforce participation, entrepreneurship, caregiving, human capital, housing, broadband access, placemaking, community leadership, and civic engagement, health and wellness, food security, and environment.&lt;/p&gt;

&lt;p pro="" sans="" source="" style="box-sizing: inherit; margin: 0px 0px 1.8em; padding: 0px; caret-color: rgb(80, 79, 81); color: rgb(80, 79, 81); font-family: "&gt;The primary purpose of this initial survey is to get a better picture of the NCR and learn more about respective topics. The Baseline Survey is also a starting point for following surveys on specific thematic areas.&lt;/p&gt;

&lt;p pro="" sans="" source="" style="box-sizing: inherit; margin: 0px 0px 1.8em; padding: 0px; caret-color: rgb(80, 79, 81); color: rgb(80, 79, 81); font-family: "&gt;To collect the necessary data, we designed an online survey using Qualtrics. The goal was to maximize participation in the survey throughout the states, across rural and urban areas, household types, and race and ethnicity.&lt;/p&gt;

&lt;p pro="" sans="" source="" style="box-sizing: inherit; margin: 0px 0px 1.8em; padding: 0px; caret-color: rgb(80, 79, 81); color: rgb(80, 79, 81); font-family: "&gt;Qualtrics&reg; distributed the survey and gathered data based on pre-defined sampling quotas and screening questions. Based on the population characteristics of each NCR state, Qualtrics&reg; applied two different data gathering methods. An online survey was distributed to households in Illinois, Indiana, Iowa, Kansas, Michigan, Minnesota, Missouri, Ohio, and Wisconsin. A mixed-method approach (online panel and Computer Assisted Telephone Interviewing &ndash; CATI) was used in Nebraska, North Dakota, and South Dakota.&lt;/p&gt;
description: The NCRCRD collected data for the 12 states in the North Central Region with an emphasis on demography, economics, health, housing, environment, and social behavior.
DOI: 10.4231/2yey-td12
title: Weathered Agent-Based Model of Microglia-Plaque Interactions

description: &lt;p&gt;Alzheimer&rsquo;s Disease (AD) is characterized by beta-amyloid (A&beta;) plaques in the brain and widespread neuronal damage. Due to high drug attrition rates in AD, there is increased interest in characterizing neuroimmune responses to A&beta; plaques. In response to AD pathology, microglia are innate phagocytotic immune cells which transition into a neuroprotective state and form barriers around plaques.&lt;/p&gt;

&lt;p&gt;This model seeks to understand the role of microglia in modifying A&beta; dynamics and barrier formation. To quantify the influence of individual microglia behaviors (activation, chemotaxis, phagocytosis, and proliferation) on plaque size and barrier coverage, we developed this agent-based model (ABM) to characterize the spatiotemporal interactions between microglia and A&beta;.&lt;/p&gt;

&lt;p&gt;Our model qualitatively reproduces mouse data trends reported in Condello et al. 2015, where the fraction of microglia coverage decreases as plaques become larger. In our model, the time to microglial arrival at the plaque boundary is significantly negatively correlated (p&lt;0.0001) with plaque size, indicating the importance of the time to microglial activation for regulating plaque size. Additionally, &lt;em&gt;in silico&lt;/em&gt; behavioral knock-out simulations show a significant increase (p&lt;0.0001) in plaque size with knocked out microglial activation, chemotaxis, or phagocytosis. The phagocytosis knockout showed a significant increase in a functionally activated microglia and plaque size, leading to a decrease in overall coverage. These simulations suggest that targeting microglial activation, phagocytosis, and chemotaxis could be a viable pharmacological strategy for the treatment of AD. &lt;/p&gt;
description: Model code from "Microglia Roles in Alzheimer’s Disease: An Agent-Based Model to Elucidate Microglial Spatiotemporal Response to Beta-Amyloid"
DOI: 10.4231/h31y-7197
title: Unmanned Aircraft Systems (UAS) Sighting Data 2016 to 2019

description: &lt;p&gt;This dataset is based on the publicly available Unmanned Aircraft System (UAS) Sightings Report published by the Federal Aviation Administration (FAA). The dataset takes information in the narrative description and extrapolates it to a row of data for each UAS sighting. The dataset also includes information about airports based on the National Plan for Integrated Airport Systems (NPIAS), also published by FAA. The dataset consists of 6,551 UAS sighting reports during the three-year period from September 2016 to August 2019. The FAA&rsquo;s UAS sighting reports generally provide information about the event date, time, city, state, and a narrative of the event. For each event, the following information was extracted from the narrative:&lt;/p&gt;

&lt;ul&gt;
 &lt;li&gt;Type of manned aircraft involved in a UAS sighting,&lt;/li&gt;
 &lt;li&gt;Source of a UAS sighting report,&lt;/li&gt;
 &lt;li&gt;UAS altitude in feet above ground level,&lt;/li&gt;
 &lt;li&gt;Distance between the UAS sighting location and the airport in nautical miles,&lt;/li&gt;
 &lt;li&gt;A nearby airport close to the UAS sighting location,&lt;/li&gt;
 &lt;li&gt;Whether manned aircraft pilot(s) takes evasive action to avoid UAS, &lt;/li&gt;
 &lt;li&gt;Whether a Mandatory Occurrence Report (MOR) was filed,&lt;/li&gt;
 &lt;li&gt;Law enforcement department(s) being notified of the UAS sighting,&lt;/li&gt;
 &lt;li&gt;Distance between manned aircraft and UAS in feet,&lt;/li&gt;
 &lt;li&gt;Position of UAS relative to manned aircraft.&lt;/li&gt;
&lt;/ul&gt;

&lt;p&gt;The FAA 2019-2023 National Plan of Integrated Airport Systems (NPIAS) Report Appendix A: List of NPIAS Airports with 5-Year Forecast Activity and Development Estimate was used to identify the category of airport that had a UAS sighting nearby. &lt;/p&gt;
description: This dataset is based on the UAS Sightings Report published by FAA. The dataset contains 6,551 reports from Sep. 2016 to Aug. 2019. The dataset also includes information about airports from the National Plan for Integrated Airport Systems (NPIAS)...
DOI: 10.4231/aspm-sy16
title: Mechanistic computational modeling of implantable, bioresorbable, drug release systems

description: &lt;p&gt;Implantable, bioresorbable drug delivery systems offer an alternative to current drug administration techniques; allowing for patient-tailored drug dosage, while also increasing patient compliance. Mechanistic mathematical modeling allows for the acceleration of the design of the release systems, and for prediction of physical anomalies that are not intuitive and might otherwise elude discovery. This study investigates short-term drug release as a function of water-mediated polymer phase inversion into a solid depot within hours to days, as well as long-term hydrolysis-mediated degradation and erosion of the implant over the next few weeks. Finite difference methods were used to model spatial and temporal changes in polymer phase inversion, solidification, and hydrolysis. Modeling revealed the impact of non-uniform drug distribution, production and transport of H+ ions, and localized polymer degradation on the diffusion of water, drug, and hydrolyzed polymer byproducts. Compared to experimental data, the computational model accurately predicted the drug release during the solidification of implants over days and drug release profiles over weeks from microspheres and implants. This work offers new insight into the impact of various parameters on drug release profiles, and is a new tool to accelerate the design process for release systems to meet a patient specific clinical need.&lt;/p&gt;
description: Computational model to predict the drug release profiles from implantable systems with a range of size and molecular weight. Offers new insight into the impact of various parameters on drug release profiles.