DOI: 10.17632/t8jv4xdsb2.1
title: SUPPLEMENTAL INFORMATION - Impacts of antibiotic exposure and its changes on immune-mediated skin diseases in infants and children: A nationwide population-based cohort study

description: Supplementary Table I. Hazard ratios for immune-mediated skin diseases according to the specific antibiotic classes compared to antibiotic non-user in infants and children Supplementary Table II. Subgroup analyses of the association between antibiotic use and immune-mediated skin diseases in infants and children Supplementary Table III. Sensitivity analyses of the association of antibiotic use with immune-mediated skin diseases among infants and children without autoimmune comorbidities Supplementary Table IV. Sensitivity analyses of the association of antibiotic use with immune-mediated skin diseases among infants and children using washout periods following the index date Supplementary Table V. Sensitivity analyses of the association of antibiotic use with atopic dermatitis among infants and children according to the infection comorbidities Supplementary Table VI. Sensitivity analyses of the association of antibiotic use with psoriasis among infants and children according to the infection comorbidities Supplementary Table VII. Sensitivity analyses of the association of antibiotic use with vitiligo among infants and children according to the infection comorbidities Supplementary Fig 1. Association between the changes in cumulative days of antibiotic exposure and pediatric immune-mediated skin diseases, including (A) atopic dermatitis, (B) psoriasis, and (C) vitiligo, among infants and children with no autoimmune comorbidities Supplementary Fig 2. Association between the changes in cumulative days of antibiotic exposure and pediatric immune-mediated skin diseases, including (A) atopic dermatitis, (B) psoriasis, and (C) vitiligo, among infants and children with 1-year washout period after index date Supplementary Fig 3. Association between the changes in cumulative days of antibiotic exposure and pediatric immune-mediated skin diseases, including (A) atopic dermatitis, (B) psoriasis, and (C) vitiligo, among infants and children with 2-year washout period after index date Supplementary Fig 4. Association between the changes in cumulative days of antibiotic exposure and risk of atopic dermatitis among infants and children with infection diseases, including (A) respiratory diseases, (B) urinary tract infections, (C) infections involving the skin, soft tissue, bone, or joint, and (D) other infections Supplementary Fig 5. Association between the changes in cumulative days of antibiotic exposure and risk of psoriasis among infants and children with infection diseases, including (A) respiratory diseases, (B) urinary tract infections, (C) infections involving the skin, soft tissue, bone, or joint, and (D) other infections Supplementary Fig 6. Association between the changes in cumulative days of antibiotic exposure and risk of vitiligo among infants and children with infection diseases, including (A) respiratory diseases, (B) urinary tract infections, (C) infections involving the skin, soft tissue, bone, or joint, and (D) other infections