cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.7420403.v1
title: Virtual Screening for the Selection of New Candidates to Trypanosoma cruzi Farnesyl Pyrophosphate Synthase Inhibitors

description: Chagas disease is a tropical parasitic disease that is caused by Trypanosoma cruzi and causes 12,000 deaths per year, mainly in Latin America. The available drugs for treating have severe limitations, including poor efficacy and high toxicity. One way to overcome these limitations is targeting priority molecules with computational tools to direct in vitro assays against validated targets. Farnesyl pyrophosphate synthase (E.C. 2.5.1.10) is an enzyme that participates in the initial stage of sterol biosynthesis, and its inhibition causes damage to membrane integrity, leading to parasite death. With the aim to identify potential inhibitors against this target from T. cruzi, hierarchical virtual screening approaches were performed through a combination of ligand-based pharmacophore models and molecular docking. First, pharmacophore model filtering resulted in 15,154 molecules that had the minimum structural requirements for inhibition (QFIT &gt; 0). These molecules were subsequently submitted to molecular docking routine, which resulted in 11,762 molecules (Grid Score between -232.74 to -0.96 kcal mol-1). The top 30 ranked molecules in these approaches were grouped in self-organizing maps. These analyses showed four promising compounds from natural products that mimic the major interactions present in the substrate/inhibitor, which indicates that these molecules can be assayed by in vitro experiments.
DOI: 10.7284/116355
title: GNSS (Global Navigation Satellite System) data collected during research cruise NH1411 using a Furuno GP-90D instrument system onboard the platform RV New Horizon

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7420388
title: Pathology of dogs in Campo Grande, MS, Brazil naturally co-infected with Leishmania infantum and Ehrlichia canis

description: Different parasites that commonly occur concomitantly can influence one another, sometimes with unpredictable effects. We evaluated pathological aspects of dogs naturally co-infected with Leishmania infantum and Ehrlichia canis. The health status of the dogs was investigated based on histopathological, hematological and biochemical analyses of 21 animals infected solely with L. infantum and 22 dogs co- infected with L. infantum and E. canis. The skin of both groups showed chronic, predominantly lymphohistioplasmacytic inflammatory reaction. The plasmacytosis in the lymphoid tissues was likely related with the hypergammaglobulinemia detected in all the dogs. The disorganization of extracellular matrix found in the reticular dermis of the inguinal region and ear, characterized by the substitution of thick collagen fibers for thin fibers, was attributed to the degree of inflammatory reaction, irrespective of the presence of parasites. In addition, the histopathological analysis revealed that twice as many dogs in the co-infected group presented Leishmania amastigotes in the ear skin than those infected solely with Leishmania, increasing the possibility of becoming infected through sand fly vectors. Our findings highlight the fact that the health of dogs infected concomitantly with L. infantum and E. canis is severely compromised due to their high levels of total plasma protein, globulins, alkaline phosphatase and creatine kinase, and severe anemia.
DOI: 10.6084/m9.figshare.7420391
title: Proposal of the PLM-PV3G model for product lifecycle management

description: Abstract The objective of the article is to propose a model for product lifecycle management in the metalworking sector. This proposal intends to facilitate the adoption of good practices in the sector, by reducing complexity and improving action assertiveness. To achieve this goal, a survey was carried out with specialists from the sector, obtaining a total of 397 questionnaires. The focus of the model is to design green products to give support to the collaboration, manufacturing and knowledge management during product lifecycle management and making it easier to adopt this methodology. The model was developed using PLS (Partial Least Squares) analysis.
DOI: 10.6084/m9.figshare.7420394
title: Toxoplasma gondii in domestic and wild animals from forest fragments of the municipality of Natal, northeastern Brazil

description: Toxoplasmosis stands out as a global disease that has felines as definitive hosts. In the municipality of Natal, Rio Grande do Norte State, Brazil, two parks are notable for their ecological and social importance. This study aimed to investigate the presence of Toxoplasma gondii in short hair cats, bats and small non-volant mammals in these two ecological reserves. Altogether, biological samples were obtained from 154 mammals, 92 wild animals from both areas and 62 domestic cats of the Parque da Cidade. In total, 22 (53.7%) non-volant wild mammals, 11 (21.5%) bats and 28 (52.8%) cats were positive for IgG anti-T. gondii antibodies using the Modified Agglutination Test (≥ 25). It was possible to detect the presence of T. gondii DNA, by means of a molecular amplification of a B1 gene fragment (155bp), in 92 tissue samples from wild animals, including Didelphis albiventris, Monodelphis domestica, Artibeus lituratus, Carollia perspicillata and Glossophaga soricina. Of the 62 cats examined by the same molecular method, T. gondii DNA could be detected in 4 cats. In this study, it was observed the circulation of T. gondii in wild species and domestic cats, demonstrating the involvement of wild and domestic animals in the cycle of T. gondii.
DOI: 10.6084/m9.figshare.7420391.v1
title: Proposal of the PLM-PV3G model for product lifecycle management

description: Abstract The objective of the article is to propose a model for product lifecycle management in the metalworking sector. This proposal intends to facilitate the adoption of good practices in the sector, by reducing complexity and improving action assertiveness. To achieve this goal, a survey was carried out with specialists from the sector, obtaining a total of 397 questionnaires. The focus of the model is to design green products to give support to the collaboration, manufacturing and knowledge management during product lifecycle management and making it easier to adopt this methodology. The model was developed using PLS (Partial Least Squares) analysis.
DOI: 10.6084/m9.figshare.7420394.v1
title: Toxoplasma gondii in domestic and wild animals from forest fragments of the municipality of Natal, northeastern Brazil

description: Toxoplasmosis stands out as a global disease that has felines as definitive hosts. In the municipality of Natal, Rio Grande do Norte State, Brazil, two parks are notable for their ecological and social importance. This study aimed to investigate the presence of Toxoplasma gondii in short hair cats, bats and small non-volant mammals in these two ecological reserves. Altogether, biological samples were obtained from 154 mammals, 92 wild animals from both areas and 62 domestic cats of the Parque da Cidade. In total, 22 (53.7%) non-volant wild mammals, 11 (21.5%) bats and 28 (52.8%) cats were positive for IgG anti-T. gondii antibodies using the Modified Agglutination Test (≥ 25). It was possible to detect the presence of T. gondii DNA, by means of a molecular amplification of a B1 gene fragment (155bp), in 92 tissue samples from wild animals, including Didelphis albiventris, Monodelphis domestica, Artibeus lituratus, Carollia perspicillata and Glossophaga soricina. Of the 62 cats examined by the same molecular method, T. gondii DNA could be detected in 4 cats. In this study, it was observed the circulation of T. gondii in wild species and domestic cats, demonstrating the involvement of wild and domestic animals in the cycle of T. gondii.
DOI: 10.6084/m9.figshare.7420382
title: Population suppression of Ceratitis capitata (Wiedemann) on table grapes using toxic baits

description: Abstract To provide alternatives to the use of spraying synthetic insecticides in C. capitata management, was evaluated the effect of “attract and kill” toxic baits on population suppression of C. capitata in three commercial areas producing table grapes. Toxic baits of Gelsura™ (4.5 L ha-1) and Success™ 0.02 CB (4.0 L ha-1) resulted in lower population levels of C. capitata adults in monitoring traps after five sequential applications at weekly intervals during the maturation period of the grapes when compared with control plots with or without insecticidal spray. In addition, plots with Gelsura™ and Success™ 0.02 CB applications showed a significant reduction in damage (%) by C. capitata on grape berries and grape bunches when compared with control plots without or with insecticidal spray. However, when compared with a plot treated by conventional management with sprays of etofenprox (Safety™, 100 g c.p. (commercial product) 100 L-1) and applications of spinosad (Success™ 0.02 CB toxic bait) with a brush, only Gelsura™ (4.5 L ha-1) showed a lower level of damage of grape berries and grape bunches. Toxic baits Gelsura™ (4.5 L ha-1) and Success™ 0.02 CB (4.0 L ha-1) are promising alternatives for the population suppression of C. capitata on table grapes.
DOI: 10.6084/m9.figshare.7420385
title: Influence of the project manager's personal characteristics on project performance

description: Abstract Projects form part of organizational activities and have a direct impact on the organization's results and performance. Improving project management performance can have a positive effect on an organization. Being ultimately responsible for project results, the project manager has factors within its personal characteristics that may affect project performance. The purpose of this study is to analyse the project manager's personal characteristics in relation to its effects on project performance using an empirical survey of 244 project managers. The results show that skills, knowledge and attitudes directly affect project performance and that personality traits do not have direct effects, but indirectly affect attitudes. The results also show that certification in project management does not directly affect project performance but has a moderating effect on the relationship between the project manager's skills and knowledge and project management performance.
DOI: 10.6084/m9.figshare.7420385.v1
title: Influence of the project manager's personal characteristics on project performance

description: Abstract Projects form part of organizational activities and have a direct impact on the organization's results and performance. Improving project management performance can have a positive effect on an organization. Being ultimately responsible for project results, the project manager has factors within its personal characteristics that may affect project performance. The purpose of this study is to analyse the project manager's personal characteristics in relation to its effects on project performance using an empirical survey of 244 project managers. The results show that skills, knowledge and attitudes directly affect project performance and that personality traits do not have direct effects, but indirectly affect attitudes. The results also show that certification in project management does not directly affect project performance but has a moderating effect on the relationship between the project manager's skills and knowledge and project management performance.
DOI: 10.7284/116352
title: Gyrocompass data collected during research cruise NH1411 using a Sperry MK-37 instrument system onboard the platform RV New Horizon

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7420382.v1
title: Population suppression of Ceratitis capitata (Wiedemann) on table grapes using toxic baits

description: Abstract To provide alternatives to the use of spraying synthetic insecticides in C. capitata management, was evaluated the effect of “attract and kill” toxic baits on population suppression of C. capitata in three commercial areas producing table grapes. Toxic baits of Gelsura™ (4.5 L ha-1) and Success™ 0.02 CB (4.0 L ha-1) resulted in lower population levels of C. capitata adults in monitoring traps after five sequential applications at weekly intervals during the maturation period of the grapes when compared with control plots with or without insecticidal spray. In addition, plots with Gelsura™ and Success™ 0.02 CB applications showed a significant reduction in damage (%) by C. capitata on grape berries and grape bunches when compared with control plots without or with insecticidal spray. However, when compared with a plot treated by conventional management with sprays of etofenprox (Safety™, 100 g c.p. (commercial product) 100 L-1) and applications of spinosad (Success™ 0.02 CB toxic bait) with a brush, only Gelsura™ (4.5 L ha-1) showed a lower level of damage of grape berries and grape bunches. Toxic baits Gelsura™ (4.5 L ha-1) and Success™ 0.02 CB (4.0 L ha-1) are promising alternatives for the population suppression of C. capitata on table grapes.
DOI: 10.7284/116349
title: Meteorological Station data collected during research cruise NH1411 using a SIO MET-System instrument system onboard the platform RV New Horizon

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7420364
title: Vesicouterine Fistula (Youssef Syndrome): Case Report and Literature Review

description: Abstract Objective To describe a case of vesicouterine fistula and to review the literature related to this condition. Methods For the review, we accessed the MEDLINE, BIREME and LILACS databases; the references of the searched articles were also reviewed. Results A 38-year-old woman, in the 1st day after her 3rd cesarean, presented heavy hematuria, which was considered secondary to a difficult dissection of the bladder. A total of 6 months after delivery, she failed to resume her regular menstrual cycles and presented cyclic menouria and amenorrhea. At this time, she had two episodes of urethral obstruction by blood clots. She remained without a correct diagnosis until about two years postdelivery, when a vesicouterine fistula was confirmed through cystoscopy. A surgical correction through open abdominal route, coupled with hysterectomy, was performed. After the surgery, the symptoms disappeared. The review showed a tendency of change in the relative frequency of the different types of genitourinary fistulae. Vesicovaginal fistulae, usually caused by inadequate care during labor, are becoming less frequent than those secondary tomedical procedures, such as vesicouterine fistulae. The most common cause of this latter kind of fistula is cesarean section, especially repeated cesarean sections. The diagnosis is confirmed through one or more imaging exams, or through cystoscopy. The most common treatment is surgical, and the routes are: open abdominal, laparoscopic, vaginal or robotic. There are some reports of success with the conservative treatment. Conclusion Vesicouterine fistulae are becoming more common because of the increase in the performance of cesarean sections, and the condition must be considered a possible complication thereof.
DOI: 10.7284/116356
title: Meteorological Station data collected during research cruise NH1411 using a SIO MET-System instrument system onboard the platform RV New Horizon

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7420355
title: Validation of the Brazilian-Portuguese Version of a Short Questionnaire to Assess Knowledge in Cardiovascular Disease Patients (CADE-Q SV)

description: Abstract Background: Patient education is an essential part of cardiovascular patients' care targeting self-management behavior to reduce risk factors and subsequent events. Herein, a short and reliable tool to assess patients' knowledge in Brazil is warranted. Objectives: To translate, culturally-adapt and psychometrically validate the Portuguese version of the Coronary Artery Disease Education Questionnaire Short Version (CADE-Q SV). Methods: The Portuguese CADE-Q SV - translated and culturally-adapted - was reviewed by five bilingual experts in cardiovascular disease. This version was then pre-tested in 21 patients, and clarity of items was checked using a Likert-type scale ranging from 1 = not clear to 10 = very clear. It was then psychometrically tested in 200 cardiovascular patients (41%women; mean age = 58.4 ± 11.6 years old). The internal consistency was assessed using Kuder-Richardson-20 (KR-20) and Cronbach's alpha, test-retest reliability through intraclass correlation coefficient (ICC), factor structure using confirmatory factor analysis, and construct validity regarding educational level, family income, and time of diagnosis. Results: All questions were considered clear by patients (clarity range:7.8-9.6). KR-20 was 0.70. All ICC values were &gt; 0.70. Factor analysis revealed 6 factors, all internally consistent. Construct validity was supported by significant differences in total scores by educational level and family income (p &lt; 0.001). The overall mean was 13.08 ± 2.61. The area with the highest knowledge was risk factors and the lowest was psychosocial risk. Conclusions: The Portuguese CADE-SV was demonstrated to have good validity and reliability. This tool can be applicable in clinical and research settings, assessing cardiovascular patients' knowledge as part of an education programming.
DOI: 10.6084/m9.figshare.7420358
title: Value perception in the consumption of convergent technology products with green attributes

description: Abstract Due to the growing concerns about environmental issues, quality of life and well-being, consumers are considering the importance of obtaining eco-friendly products or devices with green functionality features. This scenario led to the investigation of the influence of green features on the intention to purchase of convergent products, with hedonic and utilitarian bases. We developed a quantitative experimental research, with application of online questionnaires at a University in the State of Pará, aiming to study the smartphones and their different usability. The results indicate increased intention of purchase of devices with “green” features on both a hedonic and a utilitarian basis. However, the addition of “green” features was more significant in the hedonic base, suggesting a utilitarian justification, reducing the guilty feeling inherent to the acquisition of hedonic products.
DOI: 10.6084/m9.figshare.7420364.v1
title: Vesicouterine Fistula (Youssef Syndrome): Case Report and Literature Review

description: Abstract Objective To describe a case of vesicouterine fistula and to review the literature related to this condition. Methods For the review, we accessed the MEDLINE, BIREME and LILACS databases; the references of the searched articles were also reviewed. Results A 38-year-old woman, in the 1st day after her 3rd cesarean, presented heavy hematuria, which was considered secondary to a difficult dissection of the bladder. A total of 6 months after delivery, she failed to resume her regular menstrual cycles and presented cyclic menouria and amenorrhea. At this time, she had two episodes of urethral obstruction by blood clots. She remained without a correct diagnosis until about two years postdelivery, when a vesicouterine fistula was confirmed through cystoscopy. A surgical correction through open abdominal route, coupled with hysterectomy, was performed. After the surgery, the symptoms disappeared. The review showed a tendency of change in the relative frequency of the different types of genitourinary fistulae. Vesicovaginal fistulae, usually caused by inadequate care during labor, are becoming less frequent than those secondary tomedical procedures, such as vesicouterine fistulae. The most common cause of this latter kind of fistula is cesarean section, especially repeated cesarean sections. The diagnosis is confirmed through one or more imaging exams, or through cystoscopy. The most common treatment is surgical, and the routes are: open abdominal, laparoscopic, vaginal or robotic. There are some reports of success with the conservative treatment. Conclusion Vesicouterine fistulae are becoming more common because of the increase in the performance of cesarean sections, and the condition must be considered a possible complication thereof.
DOI: 10.6084/m9.figshare.7420358.v1
title: Value perception in the consumption of convergent technology products with green attributes

description: Abstract Due to the growing concerns about environmental issues, quality of life and well-being, consumers are considering the importance of obtaining eco-friendly products or devices with green functionality features. This scenario led to the investigation of the influence of green features on the intention to purchase of convergent products, with hedonic and utilitarian bases. We developed a quantitative experimental research, with application of online questionnaires at a University in the State of Pará, aiming to study the smartphones and their different usability. The results indicate increased intention of purchase of devices with “green” features on both a hedonic and a utilitarian basis. However, the addition of “green” features was more significant in the hedonic base, suggesting a utilitarian justification, reducing the guilty feeling inherent to the acquisition of hedonic products.
DOI: 10.7284/116350
title: Winch data collected during research cruise NH1411 using a Markey DUSH-5 instrument system onboard the platform RV New Horizon

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7420349
title: A cysteine protease from the latex of Ficus benjamina has in vitro anthelmintic activity against Haemonchus contortus

description: Abstract Haemonchus contortus is a gastrointestinal nematode that is responsible for high mortality rates in ruminant herds. The resistance of nematodes to synthetic anthelmintics is widespread and requires a continuous search for new bioactive molecules, such as proteins. The objective of this study was to evaluate the anthelmintic potential of a protease purified from the latex of Ficus benjamina against H. contortus . Fresh latex was collected from plants via small incisions in the green stems, the rubber was removed by centrifugation, and the latex protein extract (LPE) was obtained. After LPE fractionation with ammonium sulfate and chromatography of the fraction containing the highest proteolytic activity on CM-cellulose, a cysteine protease (FbP) was purified. FbP has a molecular mass of approximately 23.97 kDa, and its proteolytic activity was stable between pH 6.0 and pH 10 and over a broad temperature range, with optimum activity at 60 °C. FbP inhibited both the development and exsheathment of H. contortus larvae, with 50% effective concentrations of 0.26 and 0.79 mg/mL, respectively. We conclude that this cysteine protease from F. benjamina latex with anthelmintic activity against H. contortus could be a promising alternative for the development of products for use in parasite control programmes.