cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.5281/zenodo.8338962
title: Single nuclei RNAseq stratifies multiple sclerosis patients into distinct white matter glial responses

description: The lack of understanding of the cellular and molecular basis of clinical and genetic heterogeneity in progressive multiple sclerosis (MS) has hindered the search for new effective therapies. Here, to address this gap, we analysed 632,000 single nuclei RNAseq profiles of 156 brain tissue samples, comprising white matter (WM) lesions, normal appearing WM, grey matter (GM) lesions and normal appearing GM from 54 MS patients and 26 controls. We observed the expected changes in overall neuronal and glial numbers previously described within the classical lesion subtypes. We found highly cell type-specific gene expression changes in MS tissue, with distinct differences between GM and WM areas, confirming different pathologies. However, surprisingly, we did not observe distinct gene expression signatures for the classical different WM lesion types, rather a continuum of change. This indicates that classical lesion characterization better reflects changes in cell abundance than changes in cell type gene expression, and indicates a global disease effect. Furthermore, the major biological determinants of variability in gene expression in MS WM samples relate to individual patient effects, rather than to lesion types or other metadata. We identify four subgroups of MS patients with distinct WM glial gene expression signatures and patterns of oligodendrocyte stress and/or maturation, suggestive of engagement of different pathological processes, with an additional more variable regenerative astrocyte signature. The discovery of these patterns, which were also found in an independent MS patient cohort, provides a framework to use molecular biomarkers to stratify patients for optimal therapeutic approaches for progressive MS, significantly advances our mechanistic understanding of progressive MS, and highlights the need for precision-medicine approaches to address heterogeneity among MS patients.
DOI: 10.5281/zenodo.8365995
title: Data supporting

description: Data supporting
DOI: 10.5281/zenodo.8365994
title: Data supporting

description: Data supporting
DOI: 10.6084/m9.figshare.22348486.v1
title: data-Eco.Appl.xlsx

description: Data on the impact of grazing on community stability
DOI: 10.18465/ee88da9e-a10a-477b-90ef-f358f2fad44e
title: MNS Jard-sur-Mer 2017

description: Modèle Numérique de Surface obtenu par LiDAR sur la côte vendéenne au niveau de Jard-sur-Mer
DOI: 10.6084/m9.figshare.24173715
title: Supplementary Material for: Two distinct characteristics of immune microenvironment in human hepatocellular carcinoma with Wnt/β-catenin mutations

description: Introduction Immunotherapy is becoming a promising approach for unresectable-hepatocellular carcinoma (HCC); the anti-tumor response is affected by the tumor microenvironment (TME). Although Wnt/β-catenin mutations are reported to cause non-inflamed phenotype, their role on TME remains controversial. We aimed to clarify the heterogeneity of immunophenotype in HCC with Wnt/β-catenin mutations. Methods This study includes 152 resected HCCs; mutations in the catenin beta-1, adenomatous polyposis coli, or AXIN1, or AXIN2 genes were defined as Wnt/β-catenin mutations. With hierarchical cluster analyses, TME were classified into inflamed or non-inflamed classes based on the gene expressions associated with T-cell activation. Expression profiles of molecules related to cell differentiation and biliary-stem cell markers were compared between the TME classes to investigate whether differences in tumor traits were associated with TME. Results Forty of 152 (26.3%) HCCs carried the Wnt/β-catenin mutations. Of these, 33 were classified as non-inflamed (33/40, 82.5%) and 7 as inflamed (7/40, 17.5%). Non-inflamed class was characterized by low number of CD3+, CD4+, and CD8+ cells on immunostaining, and high mRNA expressions of AXIN2 and GLUL, which are involved in the canonical Wnt/β-catenin signaling and hepatocyte differentiation, respectively. Non-inflamed tumors showed higher enhancement on the hepatobiliary-phase of gadolinium-ethoxybenzyl-diethylenetriamine (Gd-EOB-DTPA)-enhanced magnetic resonance imaging (MRI) compared to inflamed tumors. HCCs classified as inflamed class are revealed to have high numbers of CD3+, CD4+, and CD8+ tumor infiltrating lymphocytes on immunostaining. This class is associated with increased expression of anti-epithelial cell adhesion molecule (EpCAM) and FOXM1 accompanied by upregulation of genes related to interferon-gamma signaling, dendritic cell migration, regulatory T cells and MDSC activation and recognized as low enhancement nodule on Gd-EOB-DTPA-enhanced MRI. Conclusion Heterogeneity of tumor traits and TME was observed in HCC with Wnt/β-catenin mutation. The potential was indicated that tumor traits and TME are determined not only by the activation of the HNF4A but also by FOXM1, both of which are downstream transcription factor of the Wnt/β-catenin signaling pathway.
DOI: 10.6084/m9.figshare.24173715.v1
title: Supplementary Material for: Two distinct characteristics of immune microenvironment in human hepatocellular carcinoma with Wnt/β-catenin mutations

description: Introduction Immunotherapy is becoming a promising approach for unresectable-hepatocellular carcinoma (HCC); the anti-tumor response is affected by the tumor microenvironment (TME). Although Wnt/β-catenin mutations are reported to cause non-inflamed phenotype, their role on TME remains controversial. We aimed to clarify the heterogeneity of immunophenotype in HCC with Wnt/β-catenin mutations. Methods This study includes 152 resected HCCs; mutations in the catenin beta-1, adenomatous polyposis coli, or AXIN1, or AXIN2 genes were defined as Wnt/β-catenin mutations. With hierarchical cluster analyses, TME were classified into inflamed or non-inflamed classes based on the gene expressions associated with T-cell activation. Expression profiles of molecules related to cell differentiation and biliary-stem cell markers were compared between the TME classes to investigate whether differences in tumor traits were associated with TME. Results Forty of 152 (26.3%) HCCs carried the Wnt/β-catenin mutations. Of these, 33 were classified as non-inflamed (33/40, 82.5%) and 7 as inflamed (7/40, 17.5%). Non-inflamed class was characterized by low number of CD3+, CD4+, and CD8+ cells on immunostaining, and high mRNA expressions of AXIN2 and GLUL, which are involved in the canonical Wnt/β-catenin signaling and hepatocyte differentiation, respectively. Non-inflamed tumors showed higher enhancement on the hepatobiliary-phase of gadolinium-ethoxybenzyl-diethylenetriamine (Gd-EOB-DTPA)-enhanced magnetic resonance imaging (MRI) compared to inflamed tumors. HCCs classified as inflamed class are revealed to have high numbers of CD3+, CD4+, and CD8+ tumor infiltrating lymphocytes on immunostaining. This class is associated with increased expression of anti-epithelial cell adhesion molecule (EpCAM) and FOXM1 accompanied by upregulation of genes related to interferon-gamma signaling, dendritic cell migration, regulatory T cells and MDSC activation and recognized as low enhancement nodule on Gd-EOB-DTPA-enhanced MRI. Conclusion Heterogeneity of tumor traits and TME was observed in HCC with Wnt/β-catenin mutation. The potential was indicated that tumor traits and TME are determined not only by the activation of the HNF4A but also by FOXM1, both of which are downstream transcription factor of the Wnt/β-catenin signaling pathway.
DOI: 10.18465/bd4f5c77-65df-415a-b2fb-753027cc33f4
title: MNS Jard-sur-Mer 2021

description: Modèle Numérique de Surface obtenu par LiDAR sur la côte vendéenne au niveau de Jard-sur-Mer
DOI: 10.18465/d2889c48-e445-4553-ab54-5a3a12503a62
title: MNS Jard-sur-Mer 2020

description: Modèle Numérique de Surface obtenu par LiDAR sur la côte vendéenne au niveau de Jard-sur-Mer
DOI: 10.18465/95215043-6c91-4198-9ba6-3c35aefc335f
title: MNT Jard-sur-Mer 2021

description: Modèle Numérique de Terrain obtenu par LiDAR sur la côte vendéenne au niveau de Jard-sur-Mer
DOI: 10.5281/zenodo.8364536
title: Results and log of LLM-KG-Bench runs described in article "Benchmarking the Abilities of Large Language Models for RDF Knowledge Graph Creation and Comprehension: How Well Do LLMs Speak Turtle?", Frey et al. 2023

description: Results and log of LLM-KG-Bench runs described in article ""Benchmarking the Abilities of Large Language Models for RDF Knowledge Graph Creation and Comprehension: How Well Do LLMs Speak Turtle?", Frey et al. 2023, to appear in proceedings for workshop DL4KG@ISWC 2023. For data on task FactExtractStatic please contact authors.
DOI: 10.5281/zenodo.8364535
title: Results and log of LLM-KG-Bench runs described in article "Benchmarking the Abilities of Large Language Models for RDF Knowledge Graph Creation and Comprehension: How Well Do LLMs Speak Turtle?", Frey et al. 2023

description: Results and log of LLM-KG-Bench runs described in article ""Benchmarking the Abilities of Large Language Models for RDF Knowledge Graph Creation and Comprehension: How Well Do LLMs Speak Turtle?", Frey et al. 2023, to appear in proceedings for workshop DL4KG@ISWC 2023. For data on task FactExtractStatic please contact authors.
DOI: 10.18465/97a0ec99-1fb6-4052-8f46-81d01645b8b5
title: MNT Jard-sur-Mer 2018

description: Modèle Numérique de Terrain obtenu par LiDAR sur la côte vendéenne au niveau de Jard-sur-Mer
DOI: 10.18465/854a26a5-527f-4e21-9c77-a85ac0882801
title: MNS Jard-sur-Mer 2018

description: Modèle Numérique de Surface obtenu par LiDAR sur la côte vendéenne au niveau de Jard-sur-Mer
DOI: 10.18465/0a9a6772-b1e6-4293-a125-ce5234e3d356
title: MNT Jard-sur-Mer 2017

description: Modèle Numérique de Terrain obtenu par LiDAR sur la côte vendéenne au niveau de Jard-sur-Mer
DOI: 10.6084/m9.figshare.24173721
title: <b>Parental emotion neglect and academic procrastination</b>

description: Parental emotion neglect affected academic procrastination,future self-continuity and ego depletion mediated the association between parental emotion neglect and late adolescents’ academic procrastination in a serial pattern
DOI: 10.18465/cdafea2c-7ea5-456e-90fd-d9f2a6fee00c
title: MNS Jard-sur-Mer 2019

description: Modèle Numérique de Surface obtenu par LiDAR sur la côte vendéenne au niveau de Jard-sur-Mer
DOI: 10.14768/9f50c31e-8295-4ee9-af95-99d6411ce4d3
title: STRATEOLE2 - C1: BeCOOL - Balloonborne Cloud Overshoot Observing Lidar - Particular Backscatter

description: A balloon-borne microlidar has been built at LATMOS to monitor cirrus optical properties and convective overshoot topography during long duration flights in the lower tropical stratosphere. Weighting less than 7 kg in a reduced volume and consuming less than 10 W, it will be involved in the CNES-Strateole2 campaign. This instrument paves the way to the use of microlidar technology for planetary missions.
DOI: 10.18454/mca.2023.40.2.3
title: Сравнение распределения напряжений на грани

description: Современное строительство и архитектура, Выпуск 9 (40) 2023
DOI: 10.5281/zenodo.8366009
title: Results from DCGAN training

description: These are the multiple files from training a DCGAN to generate more HYSPLIT data in the Pittsburgh area. The files are uploaded here as they are too large for Github.
DOI: 10.5281/zenodo.8366008
title: Results from DCGAN training

description: These are the multiple files from training a DCGAN to generate more HYSPLIT data in the Pittsburgh area. The files are uploaded here as they are too large for Github.
DOI: 10.5281/zenodo.8365953
title: Prevalence and determinants of cardiovascular risk factors in Lesotho: a population-based survey

description: These are pseudo-anonymised data from the ComBaCaL survey and belong to the manuscript "Prevalence and determinants of cardiovascular risk factors in Lesotho: a population-based survey" which can be found at https://doi.org/10.1093/inthealth/ihad058. The data dictionary explains the critical data available in the dataset. Between November 2021 and August 2022 , 6061 participants over 18 years old were visited in their households in two districts of Lesotho.
description: {"references": ["Gonz\u00e1lez Fern\u00e1ndez L, Firima E, Gupta R, Sematle MP, Khomolishoele M, Molulela M, Bane M, Meli R, Tlahani M, Lee T, Chammartin F, Geber F, Lejone TI, Ayakaka I, Weisser M, Amstutz A, Labhardt ND. Prevalence and determinants of cardiovascular risk factors in Lesotho: a population-based survey. Int Health. 2023 Aug 18:ihad058. doi: 10.1093/inthealth/ihad058."]}
DOI: 10.5281/zenodo.8365952
title: Prevalence and determinants of cardiovascular risk factors in Lesotho: a population-based survey

description: These are pseudo-anonymised data from the ComBaCaL survey and belong to the manuscript "Prevalence and determinants of cardiovascular risk factors in Lesotho: a population-based survey" which can be found at https://doi.org/10.1093/inthealth/ihad058. The data dictionary explains the critical data available in the dataset. Between November 2021 and August 2022 , 6061 participants over 18 years old were visited in their households in two districts of Lesotho.
description: {"references": ["Gonz\u00e1lez Fern\u00e1ndez L, Firima E, Gupta R, Sematle MP, Khomolishoele M, Molulela M, Bane M, Meli R, Tlahani M, Lee T, Chammartin F, Geber F, Lejone TI, Ayakaka I, Weisser M, Amstutz A, Labhardt ND. Prevalence and determinants of cardiovascular risk factors in Lesotho: a population-based survey. Int Health. 2023 Aug 18:ihad058. doi: 10.1093/inthealth/ihad058."]}
DOI: 10.18739/a20k35
title: Arctic lake transient electromagnetic (TEM) soundings 2016-2017
DOI: 10.48420/22656460
title: Supporting data for 'Modelling Wind-blown Umbrella Clouds in Lagrangian Dispersion Models'

description: Supporting data for the paper 'Modelling Wind-blown Umbrella Clouds in Lagrangian Dispersion Models'. <br> Consists of NAME input/settings files, and NAME output files containing gridded ash column loading.
DOI: 10.5066/f7ks6pmf
title: Western US Hydroclimate Scenarios Project Datasets
DOI: 10.5281/zenodo.4448512
title: A Test of the Cosmological Principle with Quasars

description: Dataset, mask and code associated with https://inspirehep.net/literature/1820376 (https://arxiv.org/abs/2009.14826) Code and README for selecting the sample from CatWISE can be found in Generatecode.tar.gz Code and README for masking the sample, evaluating the dipole, as well as the Monte Carlos for statistical significances can be found in Resultscode.tar.gz (This github repository: https://github.com/rameez3333/CatWISEdipole ) Note that the final result is for the sample with W1 less than 16.4 cut applied, whereas this file includes objects with W1 less than 16.5.
DOI: 10.6084/m9.figshare.11312930.v1
title: Evaluation of quality of life in multiple sclerosis patients: impact of fatigue, anxiety and depression

description: ABSTRACT This study aims to assess the perception of quality of life in patients with multiple sclerosis (MS) and to verify if there is an association with fatigue, anxiety and depression. This is a cross-sectional study with a sample composed by 100 individuals with a diagnosis of MS enrolled in the Centro de Referência para Atenção ao Paciente Portador de Doença Desmielinizante do Hospital da Restauração. The Functional Determination Scale for Quality of Life in Multiple Sclerosis (DEFU), the Modified Fatigue Impact Scale (MFIS-BR), and the Hospital Anxiety (HADS-S) and Depression Scale (HADS-D) were applied. Patients with a Primary progressive clinical form presented worse perception of quality of life (66.90±3.47) when compared to the Secondary progressive (71.65±5.92) and Relapse-remitting (79.00±6.62) forms, with Significant difference (p&lt;0.001). There was a strong positive correlation between the DEFU and the MFIS-BR scores (r=0.84), and a strong negative correlation between DEFU and HADS-A (r=−0.85), and DEFU and HADS-D (r=−0.82). The decrease in the perception of quality of life in patients with multiple sclerosis is more critical in progressive forms of the disease and is associated with the presence of fatigue, depression and anxiety.
DOI: 10.18465/c6bcbb50-b55d-4c46-be8c-015d055de8d8
title: MNT Les Conches 2018

description: Modèle Numérique de Terrain obtenu par LiDAR sur la côte vendéenne au niveau des Conches
DOI: 10.7488/ds/2275
title: Farmland birds on AES/control farms 2003-2015
title: Population Responses of Five Farmland Bird Species to 12 Years of Agri-environment Schemes in Northeastern Scotland

description: 1. The decline of farmland birds across Europe is an especially well-documented case of biodiversity loss, and despite land stewardship supported by funding from agri-environment schemes (AES), the negative trends have not yet been reversed. 2. To investigate the effect of AES towards farmland bird conservation, we compared abundance of five farmland bird species across twelve years and 53 farms (158 farm years = AES, 72 farm years = non AES) in Northeastern Scotland (UK), a region with relatively low intensity mixed farmland. 3. Between 2003 and 2015, on both AES and control farms, skylark (Alauda arvensis) declined in abundance, whereas tree sparrow (Passer montanus) and yellowhammer (Emberiza citrinella) abundance increased, and reed bunting (Emberiza schoeniclus) and linnet (Carduelis cannabina) populations remained relatively stable. 4. We did not detect a significant association between AES and avian abundance or population trends for any of these species, but there were positive associations with some AES management options. 5. Possible explanations for the lack of a significant AES-bird abundance association include poor uptake of the best AES options for farmland birds, sub-optimal implementation, spill-over effects from AES onto control farms, and the relatively good state of farmland habitats outwith AES in Northeastern Scotland. 6. Synthesis and applications. As with many other studies, we found a weak effect size of AES participation on farmland bird abundance, and recommend that future monitoring studies be designed after consulting a power analysis. We also suggest that the multi-membership modelling approach we apply provides an efficient means of estimating the separate associations between AES management options and bird abundance, despite them being applied in various combinations, and could be used more widely in assessment of conservation interventions.
description: The dataset contains three csv files - birds_aes.csv, birds_lmo.csv and spatial.csv. * "bird_aes.csv" contains abundance records for five species on AES (agri-environment scheme) and control farms during 2003-2015. * "birds_lmo.csv" contains abundance records for five species on AES farms and the presence/absence of specific land management options associated with each farm. * "spatial.csv" contains abundance records for five species on AES and control farms during 2003-2015 and the spatial location of each farm. Please see readme.txt for full description of each column in the three csv files.
DOI: 10.5281/zenodo.2624119
title: S13 | EUCOSMETICS | Combined Inventory of Ingredients Employed in Cosmetic Products (2000) and Revised Inventory (2006)

description: This is the collection associated with list S13 EUCOSMETICS on the NORMAN Suspect List Exchange.

https://www.norman-network.com/?q=suspect-list-exchange

S13

EUCOSMETICS

<strong>Combined Inventory of Ingredients Employed in Cosmetic Products (2000) and Revised Inventory (2006)</strong>

Merged Cosmetics CSV (4/05/2017)

CompTox EU Cosmetics List

Further curation in progress…

Merged Cosmetics InChIKeys (4/05/2017)

The scientific committee on cosmetic products and non-food products Intended for consumers - SCCNFP/0389/00 Final and Commission Decision 2006/257/EC amending the Decision 96/335/EC. Provided by Peter von der Ohe, UBA, curated by Reza Aalizadeh, University of Athens.
description: Sourced from EU Reports
DOI: 10.5281/zenodo.29983
title: Compounds With Multi-Target Activities Forming Target Cliffs And Selectivity Cliffs

description: On the basis of high-confidence activity data assembled from ChEMBL release 20, compounds active against one or more pairs of targets are provided (in the file 'Compounds_In_Target_Pairs.xlsx') for the K<sub>i</sub> and IC<sub>50</sub> value-based data sets, respectively. Target cliffs formed by selective compounds are listed in the file 'Target_Cliffs.xlsx'. In addition, selectivity cliffs formed by structurally analogous compounds with significantly different selectivity are given in the file 'Selectivity_Cliffs.xlsx'. The content of individual files is detailed in the README file.
DOI: 10.5281/zenodo.7965618
title: Dataset associated to the publication NATASTRON-22125961A arXiv:2212.10924

description: # Dataset description 1. Single stellar model grids at Zsun All single stellar model grids are labeled as "single_star_grid_Zsun_*.h5".<br> To access the dataset you should use the POSYDON v1 code and refer to the<br> code documentation, see https://github.com/POSYDON-code/POSYDON/releases/tag/v1.0.0.<br> The data can be accessed, e.g., with POSYDON as ```py<br> from posydon.grids.psygrid import PSyGrid<br> grid = PSyGrid()<br> grid.load(path_to_grid)<br> print(grid.initial_values)<br> print(grid.final_values)<br> print(grid[0].history1['log_L'])<br> print(grid[0].history1['log_Teff'])<br> ``` 2. Binary black hole population at Zsun We provide the binary black hole population in the file labeled<br> "BBH_population_Zsun.h5". This file contains all binary systems forming<br> binary black holes as simulated from a population synthesis model of 50 million<br> binaries generated with POSYDON v1 at solar metallicity. The data can be<br> accessed, e.g., with Pandas as ```py<br> import pandas as pd<br> df = pd.read_hdf('./data_release/source_data/BBH_population_Zsun.h5',<br> key='history')<br> df.head(10)<br> ``` For convenience we also provide a dataset labeled "arXiv_2212.10924.csv.gz"<br> that contains the subset of merging binary black holes obtained from<br> "BBH_population_Zsun.h5" at the time of double compact object formation used to<br> generate the Figure 4 of the main manuscript and compute the binary black hole<br> rates using the software released on https://github.com/ssbvr/BBH_merging_rates.<br> The data can be accessed, e.g., with Pandas as ```py<br> import pandas as pd<br> df = pd.read_csv('./data_release/source_data/arXiv_2212.10924.csv.gz',<br> compression='gzip')<br> df.head(10)<br> ``` Please refer to the following notebook on how use the data to compute the<br> detectable and intrinsic merging population as well as rates, see<br> https://github.com/ssbvr/BBH_merging_rates/blob/main/arXiv_221210924_POSYDON_BBH_Zsun.ipynb
DOI: 10.5281/zenodo.8032830
title: Figure Data for Characterization of Thunderstorm Cells Producing Observable Terrestrial Gamma-ray Flashes

description: This dataset contains the data required to recreate the figures from the paper Characterization of Thunderstorm Cells Producing Observable Terrestrial Gamma-ray Flashes. Each csv file contains the data for the corresponding instrument
DOI: 10.6084/m9.figshare.3398377.v2
title: Percent cover all species

description: Percent cover of all fouling species over time. 0.5% indicates that the species was present but not detected in a point count grid method of 100 points on a photograph.
DOI: 10.6084/m9.figshare.3398386.v1
title: Environmental parameters

description: Carbonate chemistry, temperature, salinity. Inputs for CO2sys program.
DOI: 10.6084/m9.figshare.3398395.v1
title: Mussel counts

description: Counts of mussels from photographs in Image J at week 10.
DOI: 10.6084/m9.figshare.3398398.v1
title: Bryozoan growth

description: Bryozoan colony growth (in cm^2) over time up to the fourth week, 3 replicate bryozoan colonies chosen haphazardly from each tile. After the fourth week, these colonies began to run into eachother, and growth was difficult to determine.