cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.5195428
title: Use of opioid substitution therapies in the treatment of opioid use disorder: results of a UK cost-effectiveness modelling study

description: <b>Aims:</b> This study investigated the cost-effectiveness of buprenorphine maintenance treatment (BMT) and methadone maintenance treatment (MMT) vs no opioid substitution therapy (OST) for the treatment of opioid use disorder, from the UK National Health Service (NHS)/personal social services (PSS) and societal perspectives over 1 year. <b>Methods:</b> Cost-effectiveness of OST vs no OST was evaluated by first replicating and then expanding an existing UK health technology assessment model. The expanded model included the impact of OST on infection rates of human immunodeficiency virus (HIV) and hepatitis C virus (HCV) infection. <b>Results:</b> Versus no OST, incremental cost-effectiveness ratios (ICERs) for BMT and MMT were £13,923 and £14,206 per quality-adjusted life year (QALY), respectively, from a NHS/PSS perspective. When total costs (NHS/PSS and societal) are considered, there are substantial savings associated with adopting OST; these savings are in excess of £14,032 for BMT vs no OST and £17,174 for MMT vs no OST over 1 year. This is primarily driven by a reduction in victim costs. OST treatment also impacted other aspects of criminality and healthcare resource use. <b>Limitations:</b> The model’s 1-year timeframe means long-term costs and benefits, and the influence of changes over time are not captured. <b>Conclusions:</b> OST can be considered cost-effective vs no OST from the UK NHS/PSS perspective, with a cost per QALY well below the UK’s willingness-to-pay threshold. There were only small differences between BMT and MMT. The availability of two or more cost-effective options is beneficial to retaining patients in OST programs. From a societal perspective, OST is estimated to save over £14,032 and £17,174 per year for BMT and MMT vs no OST, respectively, due to savings in victim costs. Further work is required to fully quantify the clinical and health economic impacts of different OST formulations and their societal impact over the long-term.
DOI: 10.6084/m9.figshare.5195284
title: Cumulative Stress Restricts Niche Filling Potential of Habitat-Forming Kelps in a Future Climate

description: Dataset for gene expression and Fv/Fm for consecutive stress assays for <i>Laminaria digitata </i>and <i>Laminaria ochroleuca</i>.
DOI: 10.6084/m9.figshare.5195428.v1
title: Use of opioid substitution therapies in the treatment of opioid use disorder: results of a UK cost-effectiveness modelling study

description: <b>Aims:</b> This study investigated the cost-effectiveness of buprenorphine maintenance treatment (BMT) and methadone maintenance treatment (MMT) vs no opioid substitution therapy (OST) for the treatment of opioid use disorder, from the UK National Health Service (NHS)/personal social services (PSS) and societal perspectives over 1 year. <b>Methods:</b> Cost-effectiveness of OST vs no OST was evaluated by first replicating and then expanding an existing UK health technology assessment model. The expanded model included the impact of OST on infection rates of human immunodeficiency virus (HIV) and hepatitis C virus (HCV) infection. <b>Results:</b> Versus no OST, incremental cost-effectiveness ratios (ICERs) for BMT and MMT were £13,923 and £14,206 per quality-adjusted life year (QALY), respectively, from a NHS/PSS perspective. When total costs (NHS/PSS and societal) are considered, there are substantial savings associated with adopting OST; these savings are in excess of £14,032 for BMT vs no OST and £17,174 for MMT vs no OST over 1 year. This is primarily driven by a reduction in victim costs. OST treatment also impacted other aspects of criminality and healthcare resource use. <b>Limitations:</b> The model’s 1-year timeframe means long-term costs and benefits, and the influence of changes over time are not captured. <b>Conclusions:</b> OST can be considered cost-effective vs no OST from the UK NHS/PSS perspective, with a cost per QALY well below the UK’s willingness-to-pay threshold. There were only small differences between BMT and MMT. The availability of two or more cost-effective options is beneficial to retaining patients in OST programs. From a societal perspective, OST is estimated to save over £14,032 and £17,174 per year for BMT and MMT vs no OST, respectively, due to savings in victim costs. Further work is required to fully quantify the clinical and health economic impacts of different OST formulations and their societal impact over the long-term.
DOI: 10.6084/m9.figshare.5195284.v1
title: Cumulative Stress Restricts Niche Filling Potential of Habitat-Forming Kelps in a Future Climate

description: Dataset for gene expression and Fv/Fm for consecutive stress assays for <i>Laminaria digitata </i>and <i>Laminaria ochroleuca</i>.
DOI: 10.6084/m9.figshare.5195122
title: Underlying data to the study: The unbearable emptiness of tweeting - about journal articles

description: Spreadsheet: Dataset of 4358 journal articles in the field of Dentistry and URL to 8206 tweets originated in the United States linking to those papers, retrieved from Altmetric.com.<br>PDF: List of journals analyzed
DOI: 10.15131/shef.data.5195032
title: Social Media Data Mining Becomes Ordinary

description: This research explored what happens when social media data mining becomes ordinary and is carried out by organisations that might be seen as the pillars of everyday life. The interviews on which the transcripts are based are discussed in Chapter 6 of the book. The referenced book contains a description of the methods. No other publications resulted from working with these transcripts.
DOI: 10.15131/shef.data.5195032.v1
title: Social Media Data Mining Becomes Ordinary

description: This research explored what happens when social media data mining becomes ordinary and is carried out by organisations that might be seen as the pillars of everyday life. The interviews on which the transcripts are based are discussed in Chapter 6 of the book. The referenced book contains a description of the methods. No other publications resulted from working with these transcripts.
DOI: 10.6084/m9.figshare.5195008
title: Unearthing Objects, Discovering Stories, and Retelling Lives

description: This introduction reflects on some of the topics raised in the special issue, especially how we tell—or retell—lives by discovering often long-hidden stories, and by unearthing objects thought to have been lost forever. The narrative presented here brings several stories together itself: that of the Doves type and its story of “lost and found”; that of the making of the special issue; and, even if briefly, that of Nicosia, the city that hosted the conference where several of this issue's contributions were shared for the first time.
DOI: 10.6084/m9.figshare.5195008.v1
title: Unearthing Objects, Discovering Stories, and Retelling Lives

description: This introduction reflects on some of the topics raised in the special issue, especially how we tell—or retell—lives by discovering often long-hidden stories, and by unearthing objects thought to have been lost forever. The narrative presented here brings several stories together itself: that of the Doves type and its story of “lost and found”; that of the making of the special issue; and, even if briefly, that of Nicosia, the city that hosted the conference where several of this issue's contributions were shared for the first time.
DOI: 10.6084/m9.figshare.5195122.v1
title: Underlying data to the study: The unbearable emptiness of tweeting - about journal articles

description: Dataset of 4358 journal articles in the field of Dentistry and URL to 8206 tweets originated in the United States linking to those papers, retrieved from Altmetric.com.
DOI: 10.6084/m9.figshare.5194909
title: Statistic scripts (R code and pdf)

description: R script used in the article.<br><br>We found a small mistake in the original script and thus corrected and updated the script on the 2018.02.16. Results are unchanged<br><br>
DOI: 10.6084/m9.figshare.5194900
title: FastContact data

description: Interaction of CELA2a and mBDNF PDB files, marked residues.Free energy calc.
DOI: 10.6084/m9.figshare.5194900.v1
title: FastContact data

description: Interaction of CELA2a and mBDNF PDB files, marked residues.Free energy calc.
DOI: 10.6084/m9.figshare.5194840
title: TED and academic lectures

description: TED and academic lectures that were used for the research.<br>
DOI: 10.6084/m9.figshare.5194840.v1
title: students’ work

description: students’ work from the academic writing course
DOI: 10.6084/m9.figshare.5194798
title: BBC words

description: A dictionary of words according to frequency from the run on the BBC between the years 2012-2015<br>
DOI: 10.6084/m9.figshare.5194804
title: Plos comparison

description: list of abstracts and summaries compared from PLOS journals.<br>
DOI: 10.6084/m9.figshare.5194909.v5
title: Statistic script

description: R script used in the article.<br><br>We found a small mistake in the original script and thus corrected and updated the script on the 2018.02.16<br><br>
DOI: 10.6084/m9.figshare.5194804.v1
title: Plos comparison

description: list of abstracts and summaries compared from PLOS journals.<br>
DOI: 10.6084/m9.figshare.5194798.v1
title: BBC rub

description: The data from the run on the BBC between the yeares 2012-2015<br>
DOI: 10.6084/m9.figshare.5194798.v2
title: BBC run

description: The data from the run on the BBC between the yeares 2012-2015<br>
DOI: 10.6084/m9.figshare.5194714
title: Supplemental Tables S1-S10 from Dissecting the contributions of time and microbe density to variation in immune gene expression

description: Supplemental Tables S1-10
DOI: 10.6084/m9.figshare.5194714.v1
title: Supplemental Tables S1-S10 from Dissecting the contributions of time and microbe density to variation in immune gene expression

description: Supplemental Tables S1-10
DOI: 10.6084/m9.figshare.5194660
title: Nzeb

description: Developing nearly Zero Energy Buildings (nZEB) represents a path toward sustainable<br>communities as required by the Energy Performance of Building Directive (EPBD). As consequence,<br>nZEB target for new or existing buildings has become a mandatory priority for the multidisciplinary<br>researchers involved in architectural engineering and building physics. Therefore, it is grown the<br>interest in design energy efficient measures for reaching the nZEB status of both new and existing<br>buildings. In this paper, the energy efficient measures adopted for reaching the nearly Zero Energy<br>Building standards, for a multi-floor residential building located in the Mediterranean area, are<br>presented. The extra cost necessary to reach the nZEB target have been calculated in the case of the<br>energy retrofit of an existing building (scenario 1) and in the case to directly realize a building with<br>achieve the nZEB status (scenario 2). Further, the two scenarios have been compared under financial<br>point of view. The results of this paper provide to builders and stakeholder useful information for<br>quantify the convenience to build a nZEB building in advance in order to prevent the additional<br>expenses necessary by future energy retrofit programs <br>
DOI: 10.6084/m9.figshare.5194660.v1
title: Nzeb

description: Developing nearly Zero Energy Buildings (nZEB) represents a path toward sustainable<br>communities as required by the Energy Performance of Building Directive (EPBD). As consequence,<br>nZEB target for new or existing buildings has become a mandatory priority for the multidisciplinary<br>researchers involved in architectural engineering and building physics. Therefore, it is grown the<br>interest in design energy efficient measures for reaching the nZEB status of both new and existing<br>buildings. In this paper, the energy efficient measures adopted for reaching the nearly Zero Energy<br>Building standards, for a multi-floor residential building located in the Mediterranean area, are<br>presented. The extra cost necessary to reach the nZEB target have been calculated in the case of the<br>energy retrofit of an existing building (scenario 1) and in the case to directly realize a building with<br>achieve the nZEB status (scenario 2). Further, the two scenarios have been compared under financial<br>point of view. The results of this paper provide to builders and stakeholder useful information for<br>quantify the convenience to build a nZEB building in advance in order to prevent the additional<br>expenses necessary by future energy retrofit programs <br>
DOI: 10.6084/m9.figshare.12899822
title: R0189_20171016a_videos

description: Rat 0189, skilled reaching data collected in Leventhal laboratory by Alexandra Bova
DOI: 10.6084/m9.figshare.12899822.v1
title: R0189_20171016a_videos

description: Rat 0189, skilled reaching data collected in Leventhal laboratory by Alexandra Bova
DOI: 10.4225/03/5964293a9b783
title: Figure S2 Raw data

description: Raw data for Figure S2 in manuscript Genetic compensation triggered by actin mutation prevents the muscle damage caused by loss of actin protein.<br>
DOI: 10.4225/03/59642917dbff4
title: Figure 5 Raw Data

description: Raw data for figure 5 of manuscript Genetic compensation triggered by actin mutation prevents the muscle damage caused by loss of actin protein.<br>
DOI: 10.4225/03/5964295a33f47
title: Figure 4 Raw data

description: Raw data for Figure 4 in manuscript Genetic compensation triggered by actin mutation prevents the muscle damage caused by loss of actin protein.<br>
DOI: 10.6084/m9.figshare.5193583
title: Jaric et al., Science responses to IUCN Red Listing. Peerj - Supplementary material

description: Supplementary material for: Jaric et al., Science responses to IUCN Red Listing. Peerj<br><br>Abstract - The IUCN Red List of Threatened Species is often advocated as a tool to assist decision-making in conservation investment and research focus. It is frequently suggested that research efforts should prioritize species in higher threat categories and those that are Data Deficient (DD). We assessed the linkage between IUCN listing and research effort in DD and Critically Endangered (CR) species, two groups generally advocated as research priorities. The analysis of the change in the research output following species classification indicated a listing effect in DD species, while such effect was observed in only a minority of CR species groups. DD species, while chronically understudied, seem to be recognized as research priorities, while research effort for endangered species appears to be driven by various factors other than the IUCN listing. Optimized conservation research focus would require international science planning efforts, harmonized through international mechanisms and promoted by financial and other incentives.
DOI: 10.4225/03/5964296e23de5
title: Figure 3 raw data

description: Raw data for figure 3 of manuscript Genetic compensation triggered by actin mutation prevents the muscle damage caused by loss of actin protein.
DOI: 10.6084/m9.figshare.5193577
title: MPAccessibleData(GeXPPos).xls

description: This dataset includes the GeXP or Seological positive cases in hospitalized children.
DOI: 10.6084/m9.figshare.5193583.v1
title: Jaric et al., Science responses to IUCN Red Listing. Peerj - Supplementary material

description: Supplementary material for: Jaric et al., Science responses to IUCN Red Listing. Peerj<br><br>Abstract - The IUCN Red List of Threatened Species is often advocated as a tool to assist decision-making in conservation investment and research focus. It is frequently suggested that research efforts should prioritize species in higher threat categories and those that are Data Deficient (DD). We assessed the linkage between IUCN listing and research effort in DD and Critically Endangered (CR) species, two groups generally advocated as research priorities. The analysis of the change in the research output following species classification indicated a listing effect in DD species, while such effect was observed in only a minority of CR species groups. DD species, while chronically understudied, seem to be recognized as research priorities, while research effort for endangered species appears to be driven by various factors other than the IUCN listing. Optimized conservation research focus would require international science planning efforts, harmonized through international mechanisms and promoted by financial and other incentives.
DOI: 10.6084/m9.figshare.5193520
title: EF_data.zip

description: matlab files contain timecourses for each subject and condition. <br>
DOI: 10.6084/m9.figshare.5193520.v1
title: EF_data.zip

description: matlab files contain timecourses for each subject and condition. <br>
DOI: 10.6084/m9.figshare.5193478
title: pub_shobe_etal_GMD

description: This repository includes a user guide for the Landlab SPACE component (presented in Shobe et al, in Geosci. Mod. Dev.), an iPython notebook with a working example of the code presented in the user guide, and an example driver script that replicates the example from section 7.3 in the manuscript.
DOI: 10.4225/03/596429833ffa8
title: Figure 2 raw data

description: Raw data for Figure 2 in manuscript Genetic compensation triggered by actin mutation prevents the muscle damage caused by loss of actin protein.<br><br>
DOI: 10.6084/m9.figshare.5193577.v2
title: MPAccessibleData(GeXPPos).xls

description: This dataset includes the GeXP or Seological positive cases in hospitalized children.
DOI: 10.6084/m9.figshare.5193577.v1
title: MPAccessibleData(GeXPPos).xls

description: This dataset includes the GeXP or Seological positive cases in hospitalized children.
DOI: 10.6084/m9.figshare.5193355
title: alldata.tar

description: Contains data and models used in the GRL paper:<br><br>The mechanisms underpinning Cenozoic intraplate volcanism in<br>eastern Australia: insights from seismic tomography and<br>geodynamic modelling<br><br>by Rawlinson, Davies and Pilia.<br><br>A readme file is included in the archive which explains its contents and how to make use of the data files.
DOI: 10.6084/m9.figshare.5193355.v1
title: alldata.tar

description: Contains data and models used in the GRL paper:<br><br>The mechanisms underpinning Cenozoic intraplate volcanism in<br>eastern Australia: insights from seismic tomography and<br>geodynamic modelling<br><br>by Rawlinson, Davies and Pilia.<br><br>A readme file is included in the archive which explains its contents and how to make use of the data files.
DOI: 10.6084/m9.figshare.5193256
title: DATA_APPB.xlsx

description: APPB Submission: "Analysis of Subjects' Vulnerability in a Touch Screen Game Using Behavioral Metrics", Payam Parsinejad and Rifat Sipahi.<br>The Excel File contains the data recorded for 2 experiments (EXP-A and EXP-B). In EXP-A, 12 subjects, and in EXP-B, 12 subjects participated.<br>The following measurements are included in the file:Num. of Strokes, Num. of Assignments, ME, SE, MSD, and MSDur (raw data)<br>also for SVM Analysis:Total Energy, Delay, and Duration (raw and standardized data)<br>IRB 11-11-19 (Northeastern University, Boston, MA)
DOI: 10.6084/m9.figshare.5190502
title: Organic and Third Phase in HNO<sub>3</sub>/TBP/<i>n</i>-Dodecane System: No Reverse Micelles

description: The composition and speciation of the organic and third phases in the system HNO<sub>3</sub>/TBP (tri-<i>n-</i>butyl phosphate)/<i>n</i>-dodecane have been examined by a combination of gravimetric, Karl Fischer analysis, chemical analysis, FTIR, and <sup>31</sup>P NMR spectroscopy, with particular emphasis on the transition from the two-phase to the three-phase region. Phase densities indicate that third-phase formation takes place for initial aqueous HNO<sub>3</sub> concentrations above 15 M, while the results from the stoichiometric analysis imply that the organic and third phases are characterized by two distinct species, namely the mono-solvate TBP⋅HNO<sub>3</sub> and the hemi-solvate TBP⋅2HNO<sub>3</sub>, respectively. Furthermore, the <sup>31</sup>P NMR spectra of organic and third phase show no significant chemical differences at the phosphorus centers, suggesting that the second HNO<sub>3</sub> molecule in the third phase is bound to HNO<sub>3</sub> rather than TBP. The third-phase FTIR spectra reveal stronger vibrational absorption bands at 1028, 1310, 1653, and 3200–3500 cm<sup>−1</sup>, reflecting higher concentrations of H<sub>2</sub>O, HNO<sub>3</sub>, and TBP. The molecular dynamics simulation data predict structures in accord with the spectroscopically identified speciation, indicating inequivalent HNO<sub>3</sub> molecules in the third phase. The predicted structures of the organic and third phases are more akin to microemulsion networks rather than the distinct, reverse micelles assumed in previous studies. H<sub>2</sub>O appears to be present as a disordered hydrogen-bonded solvate stabilizing the polar TBP/HNO<sub>3</sub> aggregates in the organic matrix, and not as a strongly bound hydrate species in aggregates with defined stoichiometry.
DOI: 10.6084/m9.figshare.5190550
title: Modeling Persistent Trends in Distributions

description: We present a nonparametric framework to model a short sequence of probability distributions that vary both due to underlying effects of sequential progression and confounding noise. To distinguish between these two types of variation and estimate the sequential-progression effects, our approach leverages an assumption that these effects follow a persistent trend. This work is motivated by the recent rise of single-cell RNA-sequencing experiments over a brief time course, which aim to identify genes relevant to the progression of a particular biological process across diverse cell populations. While classical statistical tools focus on scalar-response regression or order-agnostic differences between distributions, it is desirable in this setting to consider both the full distributions as well as the structure imposed by their ordering. We introduce a new regression model for ordinal covariates where responses are univariate distributions and the underlying relationship reflects consistent changes in the distributions over increasing levels of the covariate. This concept is formalized as a <i>trend</i> in distributions, which we define as an evolution that is linear under the Wasserstein metric. Implemented via a fast alternating projections algorithm, our method exhibits numerous strengths in simulations and analyses of single-cell gene expression data. Supplementary materials for this article are available online.
DOI: 10.6084/m9.figshare.5190550.v1
title: Modeling Persistent Trends in Distributions

description: We present a nonparametric framework to model a short sequence of probability distributions that vary both due to underlying effects of sequential progression and confounding noise. To distinguish between these two types of variation and estimate the sequential-progression effects, our approach leverages an assumption that these effects follow a persistent trend. This work is motivated by the recent rise of single-cell RNA-sequencing experiments over a brief time course, which aim to identify genes relevant to the progression of a particular biological process across diverse cell populations. While classical statistical tools focus on scalar-response regression or order-agnostic differences between distributions, it is desirable in this setting to consider both the full distributions as well as the structure imposed by their ordering. We introduce a new regression model for ordinal covariates where responses are univariate distributions and the underlying relationship reflects consistent changes in the distributions over increasing levels of the covariate. This concept is formalized as a <i>trend</i> in distributions, which we define as an evolution that is linear under the Wasserstein metric. Implemented via a fast alternating projections algorithm, our method exhibits numerous strengths in simulations and analyses of single-cell gene expression data. Supplementary materials for this article are available online.