cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.5281/zenodo.8200198
title: Real life condition evaluation of Inoserp PAN-AFRICA antivenom effectiveness in Cameroon

description: <strong>ABSTRACT</strong> <strong>Background: </strong>Snakebites is a serious public health issue but remains a neglected tropical disease. Data on antivenom effectiveness are urgently needed in Africa. We assessed effectiveness of Inoserp PAN-AFRICA (IPA), the recommended antivenom available in Cameroon. <strong>Methodology/Principal Findings</strong>: We enrolled 447 patients presenting with snakebite in 14 health facilities across Cameroon. At presentation, cytotoxicity, coagulation troubles and neurotoxicity were graded. We administered two to four vials of antivenom to patients based on hemotoxic or neurotoxic signs. We renewed antivenom administration to patients with persistence of bleedings or neurotoxicity 2 hours after each injection. We defined early improvement as a reduction of the grade of envenomation symptoms 2 hours after first injection. Medium-term effectiveness was investigated looking at disappearance of symptoms during hospitalization. After hospital discharge, a home visit was planned to assess long-term outcomes. Between October 2019 and May 2021, we enrolled 447 (93.7%), including 72% from the savannah regions. The median [IQR] age was 25 [14-40]. Envenomation was diagnosed in 369 (82.6%) participants. The antivenom was administered to 356 patients (96.5%) of whom 256 (71.9%) received one administration. Among these patients, cytotoxic symptoms were observed in 336 (94.4%) participants, coagulation disorders in 234 (65.7%) participants and neurotoxicity in 23 (6.5%) participants. Two hours after the first administration of antivenom, we observed a decrease in coagulation disorders or neurotoxicity in 75.2% and 39.1% of patients, respectively. Complete cessation of bleedings and neurotoxicity occurred in 96% and 93% of patients within 24 hours, respectively. Sequelae have been observed in 9 (3%) patients at the home visit 15 days after hospital admission and 11 (3%) died including one before antivenom injection. <strong>Conclusions/Significance</strong>: We confirmed good effectiveness of the IPA and highlighted the rapid improvement in bleeding or neurotoxicity after the first administration. Sequential administrations of low doses of antivenom, rigorously assessed at short intervals for an eventual renewal, can preserve patient safety and save antivenom.
DOI: 10.5281/zenodo.8200197
title: Real life condition evaluation of Inoserp PAN-AFRICA antivenom effectiveness in Cameroon

description: <strong>ABSTRACT</strong> <strong>Background: </strong>Snakebites is a serious public health issue but remains a neglected tropical disease. Data on antivenom effectiveness are urgently needed in Africa. We assessed effectiveness of Inoserp PAN-AFRICA (IPA), the recommended antivenom available in Cameroon. <strong>Methodology/Principal Findings</strong>: We enrolled 447 patients presenting with snakebite in 14 health facilities across Cameroon. At presentation, cytotoxicity, coagulation troubles and neurotoxicity were graded. We administered two to four vials of antivenom to patients based on hemotoxic or neurotoxic signs. We renewed antivenom administration to patients with persistence of bleedings or neurotoxicity 2 hours after each injection. We defined early improvement as a reduction of the grade of envenomation symptoms 2 hours after first injection. Medium-term effectiveness was investigated looking at disappearance of symptoms during hospitalization. After hospital discharge, a home visit was planned to assess long-term outcomes. Between October 2019 and May 2021, we enrolled 447 (93.7%), including 72% from the savannah regions. The median [IQR] age was 25 [14-40]. Envenomation was diagnosed in 369 (82.6%) participants. The antivenom was administered to 356 patients (96.5%) of whom 256 (71.9%) received one administration. Among these patients, cytotoxic symptoms were observed in 336 (94.4%) participants, coagulation disorders in 234 (65.7%) participants and neurotoxicity in 23 (6.5%) participants. Two hours after the first administration of antivenom, we observed a decrease in coagulation disorders or neurotoxicity in 75.2% and 39.1% of patients, respectively. Complete cessation of bleedings and neurotoxicity occurred in 96% and 93% of patients within 24 hours, respectively. Sequelae have been observed in 9 (3%) patients at the home visit 15 days after hospital admission and 11 (3%) died including one before antivenom injection. <strong>Conclusions/Significance</strong>: We confirmed good effectiveness of the IPA and highlighted the rapid improvement in bleeding or neurotoxicity after the first administration. Sequential administrations of low doses of antivenom, rigorously assessed at short intervals for an eventual renewal, can preserve patient safety and save antivenom.
DOI: 10.15156/bio/2938079
title: UNITE QIIME release for Fungi

description: Three sets of QIIME files are released, corresponding to the SHs resulting from clustering at the 3% distance (97% similarity) and 1% distance (99%) threshold levels. The third set of files is the result of a dynamic use of clustering thresholds, such that some SHs are delimited at the 3% distance level, some at the 2.5% distance level, some at the 2% distance level, and so on; these choices were made manually by experts of those particular lineages of fungi. The syntax is the same throughout the three sets of files. Includes singletons set as RefS (in dynamic files).
DOI: 10.15128/r2z890rt27d
title: Valley-floor widths across the Himalayan orogen [dataset]

description: Himalayan rivers transport ~10^3 Mt of sediment annually to ocean basins. Mountain valleys are an important component of this routing system: sediment storage in these valleys acts to buffer climatic and tectonic signals recorded by downstream sedimentary systems. Despite a critical need to understand the spatial distribution, volume and longevity of these valley fills, controls on valley location and geometry are unknown, and estimates of sediment volumes are based on never-tested assumptions of valley widening processes. Here we extract 1,644,215 valley-floor width measurements across the Himalaya to determine the dominant controls on valley-floor morphology, and to assess sediment storage processes. We use random forest regression to estimate the importance of potential controlling variables, and find that channel steepness, a proxy for rock uplift, is a first-order control on valley-floor width. We also analyse a novel dataset of 1,797 exhumation rates and find that valley-floor width decreases as exhumation rate increases. We therefore suggest that valley-floor width is adjusted to long-term tectonically driven exhumation rather than being controlled by water discharge or bedrock erodibility, and that valley widening predominantly results from sediment deposition along low-gradient valley floors rather than lateral bedrock erosion.
DOI: 10.5281/zenodo.5607334
title: Dataset related to article "Parkinson's disease midbrain organoids link GBA1 to Lewy pathology"

description: This record contains data related to the article "Parkinson’s disease midbrain organoids link GBA1 to Lewy pathology". <strong>Abstract</strong> Aggregation of α-synuclein protein in “Lewy bodies” or “Lewy neurites” is a defining hallmark of Parkinson’s disease neuropathology. Mutations in <em>GBA1</em>, encoding the glucosylceramide-hydrolyzing enzyme glucocerebrosidase, cause Gaucher’s disease and are the most frequent genetic risk factor for Parkinson’s disease. However, a defined link between mutations in <em>GBA1</em> and α-synuclein pathology is yet to be determined, largely because of the absence of experimental models able to recapitulate the key neuropathological signatures of the disease. Here, we present an innovative midbrain organoid culture system derived from subjects with <em>GBA1</em>-related Parkinson’s disease as the first patient-based model able to reproduce fundamental neuropathological features of the disease. We show that retention of mutant glucocerebrosidase in the endoplasmic reticulum and increased glucosylceramide levels are determinants of α-synuclein aggregation into inclusions resembling Lewy bodies and Lewy neurites in both mono- and biallelic <em>GBA1</em> mutated midbrain organoids. In this process, the entity of glucocerebrosidase activity reduction acts as an accelerating factor in the progression of α-synuclein pathology by favoring the conversion of soluble α-synuclein to its insoluble forms. We provide evidence that α-synuclein extracted from Parkinson’s samples displays seeding activity <em>in vitro</em> and, following inoculation in unaffected organoids, propagates the pathology. Finally, we demonstrate pharmacological rescue of pathological phenotypes with molecules engaging in the glucocerebrosidase pathway, suggesting that midbrain organoids could represent valuable <em>in vitro</em> platforms for drug testing in Parkinson’s disease and potentially other Lewy body disorders still lacking a definitive therapy.
DOI: 10.5281/zenodo.5607333
title: Dataset related to article "Parkinson's disease midbrain organoids link GBA1 to Lewy pathology"

description: This record contains data related to the article "Parkinson’s disease midbrain organoids link GBA1 to Lewy pathology". <strong>Abstract</strong> Aggregation of α-synuclein protein in “Lewy bodies” or “Lewy neurites” is a defining hallmark of Parkinson’s disease neuropathology. Mutations in <em>GBA1</em>, encoding the glucosylceramide-hydrolyzing enzyme glucocerebrosidase, cause Gaucher’s disease and are the most frequent genetic risk factor for Parkinson’s disease. However, a defined link between mutations in <em>GBA1</em> and α-synuclein pathology is yet to be determined, largely because of the absence of experimental models able to recapitulate the key neuropathological signatures of the disease. Here, we present an innovative midbrain organoid culture system derived from subjects with <em>GBA1</em>-related Parkinson’s disease as the first patient-based model able to reproduce fundamental neuropathological features of the disease. We show that retention of mutant glucocerebrosidase in the endoplasmic reticulum and increased glucosylceramide levels are determinants of α-synuclein aggregation into inclusions resembling Lewy bodies and Lewy neurites in both mono- and biallelic <em>GBA1</em> mutated midbrain organoids. In this process, the entity of glucocerebrosidase activity reduction acts as an accelerating factor in the progression of α-synuclein pathology by favoring the conversion of soluble α-synuclein to its insoluble forms. We provide evidence that α-synuclein extracted from Parkinson’s samples displays seeding activity <em>in vitro</em> and, following inoculation in unaffected organoids, propagates the pathology. Finally, we demonstrate pharmacological rescue of pathological phenotypes with molecules engaging in the glucocerebrosidase pathway, suggesting that midbrain organoids could represent valuable <em>in vitro</em> platforms for drug testing in Parkinson’s disease and potentially other Lewy body disorders still lacking a definitive therapy.
DOI: 10.6084/m9.figshare.23813733
title: Supplementary Material for: Application of the cytokinesis-block micronucleus assay for high dose exposures using imaging flow cytometry

description: The cytokinesis-block micronucleus (CBMN) assay is a well-established method to assess radiation-induced genetic damage in human cells. This assay has been adapted to imaging flow cytometry (IFC), allowing automated analysis of many cells, and eliminating the need to create microscope slides. Furthermore, to improve the efficiency of assay performance, a small-volume method previously developed was employed. Irradiated human blood samples were cultured, stained, and analysed by IFC to produce images of the cells. Samples were run using both manual and 96-well plate automated acquisition. Multiple parameter-based image features were collected for each sample and the results were compared to confirm that these acquisition methods are functionally identical. This paper details the multi-parametric analysis developed, and the resulting calibration curves up to 10 Gy. The calibration curves were created using a quadratic random coefficient model with Poisson errors, as well as a logistic discriminant function. The curves were then validated with blinded, irradiated samples, using relative bias and relative mean square error. Overall, the accuracy of the dose estimates was adequate for triage dosimetry (within 1 Gy of the true dose) over 90% of the time for lower doses and about half the time for higher doses, with the lowest success rate between 5 and 6 Gy where the calibration curve reached its peak and there was the smallest change in MN/BNC with dose. This work describes the application of novel multi-parametric analysis that fits the calibration curves and allows dose estimates up to 10 Gy, which were previously limited to 4 Gy. Furthermore, it demonstrates that the results from samples acquired manually and with the autosampler are functionally similar.
DOI: 10.6084/m9.figshare.23813733.v1
title: Supplementary Material for: Application of the cytokinesis-block micronucleus assay for high dose exposures using imaging flow cytometry

description: The cytokinesis-block micronucleus (CBMN) assay is a well-established method to assess radiation-induced genetic damage in human cells. This assay has been adapted to imaging flow cytometry (IFC), allowing automated analysis of many cells, and eliminating the need to create microscope slides. Furthermore, to improve the efficiency of assay performance, a small-volume method previously developed was employed. Irradiated human blood samples were cultured, stained, and analysed by IFC to produce images of the cells. Samples were run using both manual and 96-well plate automated acquisition. Multiple parameter-based image features were collected for each sample and the results were compared to confirm that these acquisition methods are functionally identical. This paper details the multi-parametric analysis developed, and the resulting calibration curves up to 10 Gy. The calibration curves were created using a quadratic random coefficient model with Poisson errors, as well as a logistic discriminant function. The curves were then validated with blinded, irradiated samples, using relative bias and relative mean square error. Overall, the accuracy of the dose estimates was adequate for triage dosimetry (within 1 Gy of the true dose) over 90% of the time for lower doses and about half the time for higher doses, with the lowest success rate between 5 and 6 Gy where the calibration curve reached its peak and there was the smallest change in MN/BNC with dose. This work describes the application of novel multi-parametric analysis that fits the calibration curves and allows dose estimates up to 10 Gy, which were previously limited to 4 Gy. Furthermore, it demonstrates that the results from samples acquired manually and with the autosampler are functionally similar.
DOI: 10.34740/kaggle/dsv/6229218
title: Asymmetric Friction Stir Welding AA5083 and AA5061
DOI: 10.5281/zenodo.8202071
title: Data for arricle entitled 'The grammaticalization of manner expressions into complementizers: Insights from Semitic languages', published in Linguistics

description: see publication
DOI: 10.5281/zenodo.8202070
title: Data for arricle entitled 'The grammaticalization of manner expressions into complementizers: Insights from Semitic languages', published in Linguistics

description: see publication
DOI: 10.6084/m9.figshare.23812830.v4
title: Development of global monthly dataset of CMIP6 climate variables for estimating evapotranspiratio

description: Regridding Global CMIP6 GCMs dataset(0.5 degree)Historical dataset:14 CMIP6 GCMs (1850-2014)Future dataset: 14CMIP6 GCMs and 4 SSP scenarios (2015-2100)Composition of dataset: Average temperature, Maximum temperature, Minimum temperature, Windspeed, Relative humidity, Solar radiationIf you are using our codes and dataset, please use the following references:Song, Y.H., Chung, E.S., Shahid, S., Kim, Y.J., Kim, D.K. 2023. Development of global monthly dataset of CMIP6 climate variables for estimating evapotranspiration. Scientific Data.<br>
DOI: 10.6084/m9.figshare.23813766
title: Supplementary Material for: Application of the cytokinesis-block micronucleus assay for high dose exposures using imaging flow cytometry

description: The cytokinesis-block micronucleus (CBMN) assay is a well-established method to assess radiation-induced genetic damage in human cells. This assay has been adapted to imaging flow cytometry (IFC), allowing automated analysis of many cells, and eliminating the need to create microscope slides. Furthermore, to improve the efficiency of assay performance, a small-volume method previously developed was employed. Irradiated human blood samples were cultured, stained, and analysed by IFC to produce images of the cells. Samples were run using both manual and 96-well plate automated acquisition. Multiple parameter-based image features were collected for each sample and the results were compared to confirm that these acquisition methods are functionally identical. This paper details the multi-parametric analysis developed, and the resulting calibration curves up to 10 Gy. The calibration curves were created using a quadratic random coefficient model with Poisson errors, as well as a logistic discriminant function. The curves were then validated with blinded, irradiated samples, using relative bias and relative mean square error. Overall, the accuracy of the dose estimates was adequate for triage dosimetry (within 1 Gy of the true dose) over 90% of the time for lower doses and about half the time for higher doses, with the lowest success rate between 5 and 6 Gy where the calibration curve reached its peak and there was the smallest change in MN/BNC with dose. This work describes the application of novel multi-parametric analysis that fits the calibration curves and allows dose estimates up to 10 Gy, which were previously limited to 4 Gy. Furthermore, it demonstrates that the results from samples acquired manually and with the autosampler are functionally similar.
DOI: 10.6084/m9.figshare.23813766.v1
title: Supplementary Material for: Application of the cytokinesis-block micronucleus assay for high dose exposures using imaging flow cytometry

description: The cytokinesis-block micronucleus (CBMN) assay is a well-established method to assess radiation-induced genetic damage in human cells. This assay has been adapted to imaging flow cytometry (IFC), allowing automated analysis of many cells, and eliminating the need to create microscope slides. Furthermore, to improve the efficiency of assay performance, a small-volume method previously developed was employed. Irradiated human blood samples were cultured, stained, and analysed by IFC to produce images of the cells. Samples were run using both manual and 96-well plate automated acquisition. Multiple parameter-based image features were collected for each sample and the results were compared to confirm that these acquisition methods are functionally identical. This paper details the multi-parametric analysis developed, and the resulting calibration curves up to 10 Gy. The calibration curves were created using a quadratic random coefficient model with Poisson errors, as well as a logistic discriminant function. The curves were then validated with blinded, irradiated samples, using relative bias and relative mean square error. Overall, the accuracy of the dose estimates was adequate for triage dosimetry (within 1 Gy of the true dose) over 90% of the time for lower doses and about half the time for higher doses, with the lowest success rate between 5 and 6 Gy where the calibration curve reached its peak and there was the smallest change in MN/BNC with dose. This work describes the application of novel multi-parametric analysis that fits the calibration curves and allows dose estimates up to 10 Gy, which were previously limited to 4 Gy. Furthermore, it demonstrates that the results from samples acquired manually and with the autosampler are functionally similar.
DOI: 10.15156/bio/2938083
title: UNITE USEARCH/UTAX release for Fungi

description: Reference file for USEARCH/UTAX. For optimized parameters and further information, please refer to the UTAX UNITE page. This is the "dynamic" release of the UNITE species hypotheses system, with singleton species hypotheses included. Any parts of the 18S and 28S are left in these sequences. This reference file can be used for ITS1-only or ITS2-only sequences if parameters trained on ITS1 or 2 only ('taxconfs' files) are used. ITS regions can be extracted using the ITSx tool.
DOI: 10.5281/zenodo.8191384
title: East Asia Reanalysis System (EARS)

description: ERAS surface (i.e., 2m) temperature
DOI: 10.5281/zenodo.8191383
title: East Asia Reanalysis System (EARS)

description: ERAS surface (i.e., 2m) temperature
DOI: 10.15156/bio/2938084
title: UNITE USEARCH/UTAX release for eukaryotes

description: Reference file for USEARCH/UTAX. For optimized parameters and further information, please refer to the UTAX UNITE page. This is the "dynamic" release of the UNITE species hypotheses system, with singleton species hypotheses included. Any parts of the 18S and 28S are left in these sequences. This reference file can be used for ITS1-only or ITS2-only sequences if parameters trained on ITS1 or 2 only ('taxconfs' files) are used. ITS regions can be extracted using the ITSx tool.
DOI: 10.5281/zenodo.8171678
title: Result data related to "Tröndle et al (2023): Public preferences for phasing-out fossil fuels in the German building and transport sectors"

description: Parameter estimations from the conjoint experiments performed in "Tröndle et al (2023): Public preferences for phasing-out fossil fuels in the German building and transport sectors". Parameter estimations are given for different: * estimands: average marginal component effects (amce) or marginal means, * variables: choice and rating, * sectors: buildings (heat) and transport sector, * subgroups: by-&lt;subgroupname&gt;. Filenames accordingly are: &lt;estimand&gt;-&lt;variable&gt;-&lt;sector&gt;.csv or &lt;estimand&gt;-&lt;variable&gt;-&lt;sector&gt;-by-&lt;subgroup&gt;.csv
DOI: 10.5281/zenodo.8171679
title: Result data related to "Tröndle et al (2023): Public preferences for phasing-out fossil fuels in the German building and transport sectors"

description: Parameter estimations from the conjoint experiments performed in "Tröndle et al (2023): Public preferences for phasing-out fossil fuels in the German building and transport sectors". Parameter estimations are given for different: * estimands: average marginal component effects (amce) or marginal means, * variables: choice and rating, * sectors: buildings (heat) and transport sector, * subgroups: by-&lt;subgroupname&gt;. Filenames accordingly are: &lt;estimand&gt;-&lt;variable&gt;-&lt;sector&gt;.csv or &lt;estimand&gt;-&lt;variable&gt;-&lt;sector&gt;-by-&lt;subgroup&gt;.csv
DOI: 10.5281/zenodo.7803030
title: Raw data related to "Tröndle et al (2023): Public preferences for phasing-out fossil fuels in the German building and transport sectors"

description: Raw survey data related to "Tröndle et al (2023): Public preferences for phasing-out fossil fuels in the German building and transport sectors".
DOI: 10.5281/zenodo.7803031
title: Raw data related to "Tröndle et al (2023): Public preferences for phasing-out fossil fuels in the German building and transport sectors"

description: Raw survey data related to "Tröndle et al (2023): Public preferences for phasing-out fossil fuels in the German building and transport sectors".
DOI: 10.11583/dtu.21836652.v1
title: Data for "Thermo-hydro-mechanical-chemical coupling in chalk reservoirs: Impact on fluid flow and deformation during water injection"

description: Normalized p_c0 (NF_pc) and Normalized Bulk Modulus (NF_E) surfaces versus sulfate concentration and temperature (units can be found in the text files)