cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.9249839.v1
title: Change in Quality of Life after a Cancer Diagnosis among a Nationally Representative Cohort of Older Adults in the US

description: Age-related decreases in Quality of Life (QoL) are often compounded by comorbidities, including cancer. This study aimed to examine QoL changes before and after a new cancer diagnosis using data from the National Health and Aging Trend Study (NHATS), linked to Medicare claims (<i>N</i> = 136). There was a significant increase in the relative odds of fair/poor self-reported health and needing help with Activities of Daily Living. There was also a marginal increase in depression, but no change in anxiety or pain scores. Results underscore importance of considering pre-cancer QoL when making treatment decisions for older adult cancer patients.
DOI: 10.6084/m9.figshare.9249809.v1
title: Tumor-associated autoantibodies in combination with alpha-fetoprotein for detection of early stage hepatocellular carcinoma - ELISA and cohort data

description: Tumour associated autoantibodies to recombinant proteins and AFP levels measured via ELISA in the serum of patients with hepatocellular carcinoma, non-cancerous chronic liver disease (NCCLD) and healthy controls. Data for both the discovery and confirmation studies.<br>
DOI: 10.6084/m9.figshare.9249770
title: Telemedicine in patients with peripheral arterial disease: is it worth the effort?

description: <b>Introduction</b>: For patients with peripheral arterial disease (PAD), the various components of telemedicine, such as telemonitoring, telecoaching, and teleconsultation, could be valuable in daily management. The objective of this review was to give an overview of the current use of telemedicine interventions in PAD. <b>Areas covered</b>: A literature search was performed for studies that evaluated patients with PAD of the aorto-pedal trajectory, who were monitored by telemedicine and acted upon accordingly. The primary outcome was health-related outcomes. The studies that were found focused mainly on wearable activity monitoring and telecoaching in PAD (n = 4) or wound monitoring after vascular surgery (n = 2). Main results indicate that telemedicine interventions are able to detect (post-operative) complications early, improve functional capacity and claudication onset time, and improve PAD patients’ quality of life. <b>Expert opinion</b>: The use of telemedicine in PAD patients is still an under-explored area. Studies investigating the use of telemedicine in PAD are very limited and show varying results. Owing to its high potential in improving physical ability, lifestyle coaching, and timely detection of deterioration, future research should focus on proper implementation of telemedicine in PAD patients, including clinical and feasibility outcomes, effect on workload of nurses, and cost-efficiency.
DOI: 10.6084/m9.figshare.9249770.v2
title: Telemedicine in patients with peripheral arterial disease: is it worth the effort?

description: <b>Introduction</b>: For patients with peripheral arterial disease (PAD), the various components of telemedicine, such as telemonitoring, telecoaching, and teleconsultation, could be valuable in daily management. The objective of this review was to give an overview of the current use of telemedicine interventions in PAD. <b>Areas covered</b>: A literature search was performed for studies that evaluated patients with PAD of the aorto-pedal trajectory, who were monitored by telemedicine and acted upon accordingly. The primary outcome was health-related outcomes. The studies that were found focused mainly on wearable activity monitoring and telecoaching in PAD (n = 4) or wound monitoring after vascular surgery (n = 2). Main results indicate that telemedicine interventions are able to detect (post-operative) complications early, improve functional capacity and claudication onset time, and improve PAD patients’ quality of life. <b>Expert opinion</b>: The use of telemedicine in PAD patients is still an under-explored area. Studies investigating the use of telemedicine in PAD are very limited and show varying results. Owing to its high potential in improving physical ability, lifestyle coaching, and timely detection of deterioration, future research should focus on proper implementation of telemedicine in PAD patients, including clinical and feasibility outcomes, effect on workload of nurses, and cost-efficiency.
DOI: 10.6084/m9.figshare.9249770.v1
title: Telemedicine in patients with peripheral arterial disease: is it worth the effort?

description: <b>Introduction</b>: For patients with peripheral arterial disease (PAD), the various components of telemedicine, such as telemonitoring, telecoaching, and teleconsultation, could be valuable in daily management. The objective of this review was to give an overview of the current use of telemedicine interventions in PAD. <b>Areas covered</b>: A literature search was performed for studies that evaluated patients with PAD of the aorto-pedal trajectory, who were monitored by telemedicine and acted upon accordingly. The primary outcome was health-related outcomes. The studies that were found focused mainly on wearable activity monitoring and telecoaching in PAD (n = 4) or wound monitoring after vascular surgery (n = 2). Main results indicate that telemedicine interventions are able to detect (post-operative) complications early, improve functional capacity and claudication onset time, and improve PAD patients’ quality of life. <b>Expert opinion</b>: The use of telemedicine in PAD patients is still an under-explored area. Studies investigating the use of telemedicine in PAD are very limited and show varying results. Owing to its high potential in improving physical ability, lifestyle coaching, and timely detection of deterioration, future research should focus on proper implementation of telemedicine in PAD patients, including clinical and feasibility outcomes, effect on workload of nurses, and cost-efficiency.
DOI: 10.6084/m9.figshare.9249671
title: Lead choice in cardiac implantable electronic devices: an Italian survey promoted by AIAC (Italian Association of Arrhythmias and Cardiac Pacing)

description: <b>Background</b>: Few data are available regarding lead preferences of electrophysiologists during cardiac implantable electronic devices (CIEDs) implantation. Aim of this survey is to evaluate the leads used, and the reasons behind these choices, in a large population of implanters. <b>Methods</b>: A questionnaire was sent to all 314 Italian centers with experience in CIED implantation. <b>Results</b>: 103 operators from 100 centers (32% of centers) responded. For atrium, passive leads represented first choice for pacemakers and defibrillators (71% and 64% of physicians, respectively), mainly for safety. For right ventricle, active fixation was preferred (61% and 93% operators in pacemaker and defibrillator patients), for higher versatility in positioning and lower dislodgement risk. For left ventricular stimulation, quadripolar leads were preferred by more than 80% of respondents, for better phrenic nerve and myocardial threshold management; active-fixation leads represent a second choice, in order to prevent or manage dislodgement (78% and 17% of respondents, respectively), but 44% of operators considered them dangerous. <b>Conclusions</b>: The choice of leads is heterogeneous. Trends are toward active-fixation right ventricular leads and passive-fixation atrial leads (particularly in pacemaker patients, considered frailer). For left ventricular stimulation, operators’ majority want to disposition all kind of leads, although quadripolar leads are the favorites.
DOI: 10.6084/m9.figshare.9249662
title: Supplementary Table 1 from Proteomic method to extract, concentrate, digest and enrich peptides from fossils with coloured (humic) substances for mass spectrometry analyses

description: Breakdown of the experimental steps comprising the two extraction methods tested (Method 1 and Method 2), FASP procedure, and stage tipping procedure.
DOI: 10.6084/m9.figshare.9249671.v1
title: Lead choice in cardiac implantable electronic devices: an Italian survey promoted by AIAC (Italian Association of Arrhythmias and Cardiac Pacing)

description: <b>Background</b>: Few data are available regarding lead preferences of electrophysiologists during cardiac implantable electronic devices (CIEDs) implantation. Aim of this survey is to evaluate the leads used, and the reasons behind these choices, in a large population of implanters. <b>Methods</b>: A questionnaire was sent to all 314 Italian centers with experience in CIED implantation. <b>Results</b>: 103 operators from 100 centers (32% of centers) responded. For atrium, passive leads represented first choice for pacemakers and defibrillators (71% and 64% of physicians, respectively), mainly for safety. For right ventricle, active fixation was preferred (61% and 93% operators in pacemaker and defibrillator patients), for higher versatility in positioning and lower dislodgement risk. For left ventricular stimulation, quadripolar leads were preferred by more than 80% of respondents, for better phrenic nerve and myocardial threshold management; active-fixation leads represent a second choice, in order to prevent or manage dislodgement (78% and 17% of respondents, respectively), but 44% of operators considered them dangerous. <b>Conclusions</b>: The choice of leads is heterogeneous. Trends are toward active-fixation right ventricular leads and passive-fixation atrial leads (particularly in pacemaker patients, considered frailer). For left ventricular stimulation, operators’ majority want to disposition all kind of leads, although quadripolar leads are the favorites.
DOI: 10.6084/m9.figshare.9249656
title: Supplementary Table 2 from Proteomic method to extract, concentrate, digest and enrich peptides from fossils with coloured (humic) substances for mass spectrometry analyses

description: Total number of unique peptides, total spectra (PSMs), and sequence coverage obtained in each fraction for each protein.
DOI: 10.6084/m9.figshare.9249656.v1
title: Supplementary Table 2 from Proteomic method to extract, concentrate, digest and enrich peptides from fossils with coloured (humic) substances for mass spectrometry analyses

description: Total number of unique peptides, total spectra (PSMs), and sequence coverage obtained in each fraction for each protein.
DOI: 10.6084/m9.figshare.9249662.v1
title: Supplementary Table 1 from Proteomic method to extract, concentrate, digest and enrich peptides from fossils with coloured (humic) substances for mass spectrometry analyses

description: Breakdown of the experimental steps comprising the two extraction methods tested (Method 1 and Method 2), FASP procedure, and stage tipping procedure.
DOI: 10.6084/m9.figshare.9249536
title: The effect of IFRS on CSR reporting

description: These data is related to the project titled "Does IFRS promote Corporate Social Responsibility reporting: Evidence from IFRS convergence in India.
DOI: 10.6084/m9.figshare.9249530
title: Experimental Paradigm and Behavioural Data + Read Me

description: The present folder contains the experimental paradigm, the behavioural data and two read me files, one explaining the variables of the experiemental design, the other explaining how to compute from the behavioural data the Cowan's K
DOI: 10.6084/m9.figshare.9249530.v1
title: Experimental Paradigm and Behavioural Data + Read Me

description: The present folder contains the experimental paradigm, the behavioural data and two read me files, one explaining the variables of the experiemental design, the other explaining how to compute from the behavioural data the Cowan's K
DOI: 10.6084/m9.figshare.9249470
title: Requirements for the Software Description Ontology (May, 2019)

description: Requirements for the Software Description Ontology (https://w3id.org/okn/o/sd), that drove the development of the ontology<br>
DOI: 10.6084/m9.figshare.9249464
title: Table S4 from Adaptation to life on land at high O<sub>2</sub> via transition from ferredoxin-to NADH-dependent redox balance

description: BLAST output of the expressed contigs against their respective genomes.
DOI: 10.6084/m9.figshare.9249467
title: Supplementary File 3 from Adaptation to life on land at high O<sub>2</sub> via transition from ferredoxin-to NADH-dependent redox balance

description: Pyruvate : ferredoxin oxidoreductase (PFO) and iron only hydrogenase ([Fe]-HYD) are common enzymes among eukaryotic microbes that inhabit anaerobic niches. Their function is to maintain redox balance by donating electrons from food oxidation via ferredoxin (Fd) to protons, generating H<sub>2</sub> as a waste product. Operating in series, they constitute a soluble electron transport chain of one-electron transfers between FeS clusters. They fulfil the same function—redox balance—served by two electron-transfers in the NADH- and O<sub>2</sub>-dependent respiratory chains of mitochondria. Although they possess O<sub>2</sub>-sensitive FeS clusters, PFO, Fd and [Fe]-HYD are also present among numerous algae that produce O<sub>2</sub>. The evolutionary persistence of these enzymes among eukaryotic aerobes is traditionally explained as adaptation to facultative anaerobic growth. Here, we show that algae express enzymes of anaerobic energy metabolism at ambient O<sub>2</sub> levels (21% v/v), <i>Chlamydomonas reinhardtii</i> expresses them with diurnal regulation. High O<sub>2</sub> environments arose on Earth only some approximately 450 million years ago. Gene presence/absence and gene expression data indicate that during the transition to high O<sub>2</sub> environments and terrestrialization, diverse algal lineages retained enzymes of Fd-dependent one-electron-based redox balance, while the land plant and land animal lineages underwent irreversible specialization to redox balance involving the O<sub>2</sub>-insensitive two-electron carrier NADH.
DOI: 10.6084/m9.figshare.9249461
title: Supplementary File 2 from Adaptation to life on land at high O<sub>2</sub> via transition from ferredoxin-to NADH-dependent redox balance

description: Pyruvate : ferredoxin oxidoreductase (PFO) and iron only hydrogenase ([Fe]-HYD) are common enzymes among eukaryotic microbes that inhabit anaerobic niches. Their function is to maintain redox balance by donating electrons from food oxidation via ferredoxin (Fd) to protons, generating H<sub>2</sub> as a waste product. Operating in series, they constitute a soluble electron transport chain of one-electron transfers between FeS clusters. They fulfil the same function—redox balance—served by two electron-transfers in the NADH- and O<sub>2</sub>-dependent respiratory chains of mitochondria. Although they possess O<sub>2</sub>-sensitive FeS clusters, PFO, Fd and [Fe]-HYD are also present among numerous algae that produce O<sub>2</sub>. The evolutionary persistence of these enzymes among eukaryotic aerobes is traditionally explained as adaptation to facultative anaerobic growth. Here, we show that algae express enzymes of anaerobic energy metabolism at ambient O<sub>2</sub> levels (21% v/v), <i>Chlamydomonas reinhardtii</i> expresses them with diurnal regulation. High O<sub>2</sub> environments arose on Earth only some approximately 450 million years ago. Gene presence/absence and gene expression data indicate that during the transition to high O<sub>2</sub> environments and terrestrialization, diverse algal lineages retained enzymes of Fd-dependent one-electron-based redox balance, while the land plant and land animal lineages underwent irreversible specialization to redox balance involving the O<sub>2</sub>-insensitive two-electron carrier NADH.
DOI: 10.6084/m9.figshare.9249464.v1
title: Table S4 from Adaptation to life on land at high O<sub>2</sub> via transition from ferredoxin-to NADH-dependent redox balance

description: BLAST output of the expressed contigs against their respective genomes.
DOI: 10.6084/m9.figshare.9249467.v1
title: Supplementary File 3 from Adaptation to life on land at high O<sub>2</sub> via transition from ferredoxin-to NADH-dependent redox balance

description: Pyruvate : ferredoxin oxidoreductase (PFO) and iron only hydrogenase ([Fe]-HYD) are common enzymes among eukaryotic microbes that inhabit anaerobic niches. Their function is to maintain redox balance by donating electrons from food oxidation via ferredoxin (Fd) to protons, generating H<sub>2</sub> as a waste product. Operating in series, they constitute a soluble electron transport chain of one-electron transfers between FeS clusters. They fulfil the same function—redox balance—served by two electron-transfers in the NADH- and O<sub>2</sub>-dependent respiratory chains of mitochondria. Although they possess O<sub>2</sub>-sensitive FeS clusters, PFO, Fd and [Fe]-HYD are also present among numerous algae that produce O<sub>2</sub>. The evolutionary persistence of these enzymes among eukaryotic aerobes is traditionally explained as adaptation to facultative anaerobic growth. Here, we show that algae express enzymes of anaerobic energy metabolism at ambient O<sub>2</sub> levels (21% v/v), <i>Chlamydomonas reinhardtii</i> expresses them with diurnal regulation. High O<sub>2</sub> environments arose on Earth only some approximately 450 million years ago. Gene presence/absence and gene expression data indicate that during the transition to high O<sub>2</sub> environments and terrestrialization, diverse algal lineages retained enzymes of Fd-dependent one-electron-based redox balance, while the land plant and land animal lineages underwent irreversible specialization to redox balance involving the O<sub>2</sub>-insensitive two-electron carrier NADH.
DOI: 10.6084/m9.figshare.9249458
title: Supplementary File 1 from Adaptation to life on land at high O<sub>2</sub> via transition from ferredoxin-to NADH-dependent redox balance

description: Pyruvate : ferredoxin oxidoreductase (PFO) and iron only hydrogenase ([Fe]-HYD) are common enzymes among eukaryotic microbes that inhabit anaerobic niches. Their function is to maintain redox balance by donating electrons from food oxidation via ferredoxin (Fd) to protons, generating H<sub>2</sub> as a waste product. Operating in series, they constitute a soluble electron transport chain of one-electron transfers between FeS clusters. They fulfil the same function—redox balance—served by two electron-transfers in the NADH- and O<sub>2</sub>-dependent respiratory chains of mitochondria. Although they possess O<sub>2</sub>-sensitive FeS clusters, PFO, Fd and [Fe]-HYD are also present among numerous algae that produce O<sub>2</sub>. The evolutionary persistence of these enzymes among eukaryotic aerobes is traditionally explained as adaptation to facultative anaerobic growth. Here, we show that algae express enzymes of anaerobic energy metabolism at ambient O<sub>2</sub> levels (21% v/v), <i>Chlamydomonas reinhardtii</i> expresses them with diurnal regulation. High O<sub>2</sub> environments arose on Earth only some approximately 450 million years ago. Gene presence/absence and gene expression data indicate that during the transition to high O<sub>2</sub> environments and terrestrialization, diverse algal lineages retained enzymes of Fd-dependent one-electron-based redox balance, while the land plant and land animal lineages underwent irreversible specialization to redox balance involving the O<sub>2</sub>-insensitive two-electron carrier NADH.
DOI: 10.6084/m9.figshare.9249461.v1
title: Supplementary File 2 from Adaptation to life on land at high O<sub>2</sub> via transition from ferredoxin-to NADH-dependent redox balance

description: Pyruvate : ferredoxin oxidoreductase (PFO) and iron only hydrogenase ([Fe]-HYD) are common enzymes among eukaryotic microbes that inhabit anaerobic niches. Their function is to maintain redox balance by donating electrons from food oxidation via ferredoxin (Fd) to protons, generating H<sub>2</sub> as a waste product. Operating in series, they constitute a soluble electron transport chain of one-electron transfers between FeS clusters. They fulfil the same function—redox balance—served by two electron-transfers in the NADH- and O<sub>2</sub>-dependent respiratory chains of mitochondria. Although they possess O<sub>2</sub>-sensitive FeS clusters, PFO, Fd and [Fe]-HYD are also present among numerous algae that produce O<sub>2</sub>. The evolutionary persistence of these enzymes among eukaryotic aerobes is traditionally explained as adaptation to facultative anaerobic growth. Here, we show that algae express enzymes of anaerobic energy metabolism at ambient O<sub>2</sub> levels (21% v/v), <i>Chlamydomonas reinhardtii</i> expresses them with diurnal regulation. High O<sub>2</sub> environments arose on Earth only some approximately 450 million years ago. Gene presence/absence and gene expression data indicate that during the transition to high O<sub>2</sub> environments and terrestrialization, diverse algal lineages retained enzymes of Fd-dependent one-electron-based redox balance, while the land plant and land animal lineages underwent irreversible specialization to redox balance involving the O<sub>2</sub>-insensitive two-electron carrier NADH.
DOI: 10.6084/m9.figshare.9249452
title: Table S1 from Adaptation to life on land at high O<sub>2</sub> via transition from ferredoxin-to NADH-dependent redox balance

description: Annotations of the functions of the eukaryote prokaryote clusters from Ku et al., 2015 and eukaryote monophyly in EPC trees.
DOI: 10.6084/m9.figshare.9249455
title: Table S3 from Adaptation to life on land at high O<sub>2</sub> via transition from ferredoxin-to NADH-dependent redox balance

description: FASTA headers of all the sequences used in the study along with their aliases.
DOI: 10.6084/m9.figshare.9249458.v1
title: Supplementary File 1 from Adaptation to life on land at high O<sub>2</sub> via transition from ferredoxin-to NADH-dependent redox balance

description: Pyruvate : ferredoxin oxidoreductase (PFO) and iron only hydrogenase ([Fe]-HYD) are common enzymes among eukaryotic microbes that inhabit anaerobic niches. Their function is to maintain redox balance by donating electrons from food oxidation via ferredoxin (Fd) to protons, generating H<sub>2</sub> as a waste product. Operating in series, they constitute a soluble electron transport chain of one-electron transfers between FeS clusters. They fulfil the same function—redox balance—served by two electron-transfers in the NADH- and O<sub>2</sub>-dependent respiratory chains of mitochondria. Although they possess O<sub>2</sub>-sensitive FeS clusters, PFO, Fd and [Fe]-HYD are also present among numerous algae that produce O<sub>2</sub>. The evolutionary persistence of these enzymes among eukaryotic aerobes is traditionally explained as adaptation to facultative anaerobic growth. Here, we show that algae express enzymes of anaerobic energy metabolism at ambient O<sub>2</sub> levels (21% v/v), <i>Chlamydomonas reinhardtii</i> expresses them with diurnal regulation. High O<sub>2</sub> environments arose on Earth only some approximately 450 million years ago. Gene presence/absence and gene expression data indicate that during the transition to high O<sub>2</sub> environments and terrestrialization, diverse algal lineages retained enzymes of Fd-dependent one-electron-based redox balance, while the land plant and land animal lineages underwent irreversible specialization to redox balance involving the O<sub>2</sub>-insensitive two-electron carrier NADH.
DOI: 10.6084/m9.figshare.9249455.v1
title: Table S3 from Adaptation to life on land at high O<sub>2</sub> via transition from ferredoxin-to NADH-dependent redox balance

description: FASTA headers of all the sequences used in the study along with their aliases.
DOI: 10.6084/m9.figshare.9249452.v1
title: Table S1 from Adaptation to life on land at high O<sub>2</sub> via transition from ferredoxin-to NADH-dependent redox balance

description: Annotations of the functions of the eukaryote prokaryote clusters from Ku et al., 2015 and eukaryote monophyly in EPC trees.