cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.20455049
title: Clinical management of fever in children in Brazil: practical recommendations from an expert panel

description: ABSTRACT The objective of this study was to answer several questions related to the assessment and treatment of fever, as well as other controversies that exist during its management in pediatric patients. First, an advisory board with medical experts was conducted to discuss the clinical journey of these patients, considering the main challenges and possible solutions. After this discussion, a non-systematic literature review was performed, between November 2019 and January 2020, to collect the most relevant evidence available in the scientific databases MEDLINE, Lilacs, and SciELO. A narrative review was carried out based on scientific evidence and on extensive experience of experts in clinical practice. The experts developed a set of recommendations and clarifications about the assessment of the severity of fever in pediatrics, the need for treatment and the choice of the most appropriate antipyretic. The most common controversies in the management of fever in pediatric patients were also addressed, such as alternating antipyretics, persistent fever, and dose equivalence. In primary management of pediatric patients, fever should be seen as a relevant symptom that requires treatment with antipyretics in potentially more complex or severe cases, when it causes discomfort to children or is associated with infectious diseases.
DOI: 10.6084/m9.figshare.20455049.v1
title: Clinical management of fever in children in Brazil: practical recommendations from an expert panel

description: ABSTRACT The objective of this study was to answer several questions related to the assessment and treatment of fever, as well as other controversies that exist during its management in pediatric patients. First, an advisory board with medical experts was conducted to discuss the clinical journey of these patients, considering the main challenges and possible solutions. After this discussion, a non-systematic literature review was performed, between November 2019 and January 2020, to collect the most relevant evidence available in the scientific databases MEDLINE, Lilacs, and SciELO. A narrative review was carried out based on scientific evidence and on extensive experience of experts in clinical practice. The experts developed a set of recommendations and clarifications about the assessment of the severity of fever in pediatrics, the need for treatment and the choice of the most appropriate antipyretic. The most common controversies in the management of fever in pediatric patients were also addressed, such as alternating antipyretics, persistent fever, and dose equivalence. In primary management of pediatric patients, fever should be seen as a relevant symptom that requires treatment with antipyretics in potentially more complex or severe cases, when it causes discomfort to children or is associated with infectious diseases.
DOI: 10.5258/soton/d2236
title: Dataset to support the paper 'Actively Q-switched radially polarized Ho:YAG laser with an intra-cavity laser-written S-waveplate'

description: Dataset for 'Actively Q-switched radially polarized Ho:YAG laser with an intra-cavity laser-written S-waveplate' in Optics Letters This dataset contains the data used in the generation of Figures 2 and 3 in the manuscript. The figures are as follows: Fig. 2. Output power curve for the Q-switched Ho:YAG laser at a 40 kHz repetition rate. Inset, top-left: exemplar variation of the slow axis azimuth across an S-waveplate. Inset, bottom-right: photograph of the fabricated S-waveplate. Fig. 3. (a) Single pulse trace, (b) pulse train and (c) emission spectrum of the radially polarized Q-switched Ho:YAG laser operating at 40 kHz. (d) Variation in the output pulse energy and pulse duration as a function of the AOM repetition rate.
DOI: 10.6084/m9.figshare.20455054
title: Dermatoglyphic and acoustic analysis of singing voices: a multiple case preliminary report

description: ABSTRACT Purpose: to identify genetically enhanced physical skills (speed, strength, endurance and motor coordination), provided by the dermatoglyphic method and to analyze the preliminary correlation between dermatoglyphic and acoustic data of lyrical and pop singers. Methods: the study was approved by the Ethics and Research Committee. Four male singers were evaluated (two lyrical and two pop singers), 31-53 years old. Data collection and analysis procedures comprised (1) Survey -Self-Perception of Vocal Characteristics in Singers (vocal habits, voice performance and phenotypic characteristics); (2) Dermatoglyphic Profile (fingerprint image digitalization: predominance of digital drawings (Arch, Loop and Whorl); scores of deltas (D10); the Total Ridge Count (TRC); digital formula and dermatoglyphic profile (aerobic, anaerobic and mix)); (3) Acoustic Analysis (the Expression Evaluator script application to the audio recordings: f0, intensity, spectral slope and long-term average spectrum - LTAS values); and (4) Integrated (Statistical) Analysis; cluster analysis. Results: correlations were found between dermatoglyphic variables (Arch, Loop, Whorl, D10, TRC) and acoustic parameters (f0 (median); intensity (asymmetry); spectral slope (mean); and LTAS (SD)). The dermatoglyphic profile did not segregate singing styles. Conclusion: the dermatoglyphic profiles showed a preliminary correlation with the acoustic vocal measures, especially f0 and LTAS measures.
DOI: 10.6084/m9.figshare.20455052
title: Low T3 syndrome as a prognostic factor in patients in the intensive care unit: an observational cohort study

description: ABSTRACT Objective: To assess euthyroid sick syndrome as a prognostic factor in patients in the intensive care unit; to detect factors that may affect mortality; and to develop an equation to calculate death probability. Methods: This was a longitudinal, observational, nonconcurrent cohort study developed in the intensive care unit of Fundação Santa Casa de Misericórdia do Pará. One hundred adults with no prior documented endocrinopathy were submitted to a 20mL blood sample collection for the measurement of thyroid stimulating hormone, free tetraiodothyronine, free triiodothyronine and reverse triiodothyronine. Results: Most patients were female, aged 20 to 29 years. Most patients who died were older (median age of 48 years), and euthyroid sick syndrome was present in 97.5% of them. Euthyroid sick syndrome was related to death, comorbidities, age and length of stay in the intensive care unit (median of 7.5 days). There was an association between lower thyroid stimulating hormone and death. Patients with free triiodothyronine levels below 2.9pg/mL were more likely to die; reverse triiodothyronine rates were above 0.2ng/mL in those who died. Free triiodothyronine had greater sensitivity and accuracy, and reverse triiodothyronine had greater specificity to predict mortality. Based on the results and cutoff points, a multiple logistic regression formula was developed to calculate the probability of death. Conclusion: The main limitation of this study is the fact that it was conducted in a reference hospital for maternal and child care; therefore, there was a greater number of female patients and, consequently, a sampling bias existed. However, opportune measurement of free and reverse triiodothyronine levels in critical patients and application of the proposed equation are suggested.
DOI: 10.6084/m9.figshare.20455052.v1
title: Low T3 syndrome as a prognostic factor in patients in the intensive care unit: an observational cohort study

description: ABSTRACT Objective: To assess euthyroid sick syndrome as a prognostic factor in patients in the intensive care unit; to detect factors that may affect mortality; and to develop an equation to calculate death probability. Methods: This was a longitudinal, observational, nonconcurrent cohort study developed in the intensive care unit of Fundação Santa Casa de Misericórdia do Pará. One hundred adults with no prior documented endocrinopathy were submitted to a 20mL blood sample collection for the measurement of thyroid stimulating hormone, free tetraiodothyronine, free triiodothyronine and reverse triiodothyronine. Results: Most patients were female, aged 20 to 29 years. Most patients who died were older (median age of 48 years), and euthyroid sick syndrome was present in 97.5% of them. Euthyroid sick syndrome was related to death, comorbidities, age and length of stay in the intensive care unit (median of 7.5 days). There was an association between lower thyroid stimulating hormone and death. Patients with free triiodothyronine levels below 2.9pg/mL were more likely to die; reverse triiodothyronine rates were above 0.2ng/mL in those who died. Free triiodothyronine had greater sensitivity and accuracy, and reverse triiodothyronine had greater specificity to predict mortality. Based on the results and cutoff points, a multiple logistic regression formula was developed to calculate the probability of death. Conclusion: The main limitation of this study is the fact that it was conducted in a reference hospital for maternal and child care; therefore, there was a greater number of female patients and, consequently, a sampling bias existed. However, opportune measurement of free and reverse triiodothyronine levels in critical patients and application of the proposed equation are suggested.
DOI: 10.6084/m9.figshare.20455054.v1
title: Dermatoglyphic and acoustic analysis of singing voices: a multiple case preliminary report

description: ABSTRACT Purpose: to identify genetically enhanced physical skills (speed, strength, endurance and motor coordination), provided by the dermatoglyphic method and to analyze the preliminary correlation between dermatoglyphic and acoustic data of lyrical and pop singers. Methods: the study was approved by the Ethics and Research Committee. Four male singers were evaluated (two lyrical and two pop singers), 31-53 years old. Data collection and analysis procedures comprised (1) Survey -Self-Perception of Vocal Characteristics in Singers (vocal habits, voice performance and phenotypic characteristics); (2) Dermatoglyphic Profile (fingerprint image digitalization: predominance of digital drawings (Arch, Loop and Whorl); scores of deltas (D10); the Total Ridge Count (TRC); digital formula and dermatoglyphic profile (aerobic, anaerobic and mix)); (3) Acoustic Analysis (the Expression Evaluator script application to the audio recordings: f0, intensity, spectral slope and long-term average spectrum - LTAS values); and (4) Integrated (Statistical) Analysis; cluster analysis. Results: correlations were found between dermatoglyphic variables (Arch, Loop, Whorl, D10, TRC) and acoustic parameters (f0 (median); intensity (asymmetry); spectral slope (mean); and LTAS (SD)). The dermatoglyphic profile did not segregate singing styles. Conclusion: the dermatoglyphic profiles showed a preliminary correlation with the acoustic vocal measures, especially f0 and LTAS measures.
DOI: 10.6084/m9.figshare.20455055
title: Mother’s education and family relations protect children from dental caries experience: a salutogenic approach

description: Abstract The objective of this study was to identify dental caries-protective factors among 5-year-old children using the salutogenic theory. A cross-sectional study was conducted in a small-sized municipality in the Southeast region of Brazil, with a representative sample of 247 children registered in preschool and their respective mothers. The data were collected through questionnaires administered to the mothers about the socioeconomic, behavioral, and biological aspects of the mother and children. Additionally, the collections included validated instruments concerning psychosocial aspects, such as a sense of coherence, resilience, family cohesion and religiosity, and intraoral examinations of the children through the decayed-missing-filled primary teeth (dmft) index. All examinations were performed by a trained and calibrated examiner. The non-adjusted and adjusted odds ratios (OR) and their respective confidence intervals (CI) were estimated using multiple logistic regression with a hierarchical model. Among the examined children, 41.7% were caries-free. In the final model, the chances of the absence of dental caries experience (dmft = 0) were greater in children with mothers who had higher education levels (&gt; 8 years of study) (OR = 2.55 [95%CIi:1.42–4.59]) and those who lived in an environment of high family cohesion (OR = 3.66 [95%CI: 1.19–11.29]). The results indicated that mothers’ level of education and family relationships are protective factors against dental caries in 5-year-old children, which overlapped with behavioral and biological factors.
DOI: 10.6084/m9.figshare.20455055.v1
title: Mother’s education and family relations protect children from dental caries experience: a salutogenic approach

description: Abstract The objective of this study was to identify dental caries-protective factors among 5-year-old children using the salutogenic theory. A cross-sectional study was conducted in a small-sized municipality in the Southeast region of Brazil, with a representative sample of 247 children registered in preschool and their respective mothers. The data were collected through questionnaires administered to the mothers about the socioeconomic, behavioral, and biological aspects of the mother and children. Additionally, the collections included validated instruments concerning psychosocial aspects, such as a sense of coherence, resilience, family cohesion and religiosity, and intraoral examinations of the children through the decayed-missing-filled primary teeth (dmft) index. All examinations were performed by a trained and calibrated examiner. The non-adjusted and adjusted odds ratios (OR) and their respective confidence intervals (CI) were estimated using multiple logistic regression with a hierarchical model. Among the examined children, 41.7% were caries-free. In the final model, the chances of the absence of dental caries experience (dmft = 0) were greater in children with mothers who had higher education levels (&gt; 8 years of study) (OR = 2.55 [95%CIi:1.42–4.59]) and those who lived in an environment of high family cohesion (OR = 3.66 [95%CI: 1.19–11.29]). The results indicated that mothers’ level of education and family relationships are protective factors against dental caries in 5-year-old children, which overlapped with behavioral and biological factors.
DOI: 10.6084/m9.figshare.20318871
title: Supplementary Material for: Post-operative severity assessment in sheep

description: Introduction: Sheep are frequently used in translational surgical orthopedic studies. Naturally, a good pain management is mandatory for animal welfare, although it is also important with regard to data quality. However, methods for adequate severity assessment, especially considering pain, are rather rare regarding large animal models. Therefore, in the present study, accompanying a surgical pilot study telemetry and the Sheep Grimace Scale (SGS) were used in addition to clinical scoring for severity assessment after surgical interventions in sheep. Methods: Telemetric devices were implanted in a first surgery subcutaneously into four German blackheaded mutton ewes (4-5 years, 77-115kg). After three to four weeks of recovery, sheep underwent tendon ablation of the left M. infraspinatus. Clinical scoring and video recordings for SGS analysis were performed after both surgeries and heart rate (HR) and general activity were monitored by telemetry. Results: Immediately after surgery, clinical score and HR were slightly increased and activity was decreased in individual sheep after both surgeries. The SGS mildly elevated directly after transmitter implantation, but increased to higher levels after tendon ablation immediately after surgery and on the following day. Conclusion: In summary, SGS and telemetry-derived data were suitable to detect post-operative pain in sheep with the potential to improve individual pain recognition and postoperative management, which consequently contributes to refinement.
DOI: 10.6084/m9.figshare.20455057
title: Selective waste collection in the city of São Paulo: urban public services under the neoliberal logic

description: Abstract The aim of this study is to analyze the influence of the neoliberal logic on São Paulo’s municipal selective waste collection program. The study analyzed a set of public hearings and events that discussed waste management in São Paulo to understand the discourses, views and actions undertaken by the actors that form the system. Results showed that the neoliberal logic has been present in the agenda of all the municipal administrations since the beginning of the selective collection program in the city, whether they assume center-right or center-left positions. The consequence of this is a tendency to make technocratic choices that, under the arguments of “modernity” and need for “technological solutions”, end up being centralized in technology, socially exclusionary, and inefficient.
DOI: 10.6084/m9.figshare.20455057.v1
title: Selective waste collection in the city of São Paulo: urban public services under the neoliberal logic

description: Abstract The aim of this study is to analyze the influence of the neoliberal logic on São Paulo’s municipal selective waste collection program. The study analyzed a set of public hearings and events that discussed waste management in São Paulo to understand the discourses, views and actions undertaken by the actors that form the system. Results showed that the neoliberal logic has been present in the agenda of all the municipal administrations since the beginning of the selective collection program in the city, whether they assume center-right or center-left positions. The consequence of this is a tendency to make technocratic choices that, under the arguments of “modernity” and need for “technological solutions”, end up being centralized in technology, socially exclusionary, and inefficient.
DOI: 10.6084/m9.figshare.20455058
title: Physiology and growth of maize under salinity of water and application of hydrogen peroxide

description: ABSTRACT The salinity of irrigation water or soil is the abiotic factor that most negatively impacts the yield of crops, including green maize, so it is necessary to find alternatives to ensure production. In this context, this study aimed to evaluate gas exchange, photosynthetic pigments, and growth of maize under salinity of irrigation water and application of hydrogen peroxide. The experiment was conducted at the Center of Sciences and Agrifood Technology, Pombal, PB, belonging to the Federal University of Campina Grande, in the period from January to February 2015, using the maize hybrid ‘AG 1051’. The treatments consisted of two salinity levels of irrigation water (0.3 and 2.0 dS m-1) and five concentrations of hydrogen peroxide (0, 40, 80, 160, and 320 µmol L-1) applied via irrigation water. The experimental design was completely randomized, in a 2 × 5 factorial scheme, with four replicates. ECw of 2.0 dS m-1 reduces transpiration, stomatal conductance, total chlorophyll, carotenoids, and initial growth, but does not affect the dry mass accumulation of maize plants. Application of H2O2 via soil varying from 0 to 320 µmol L-1 causes reductions in the CO2 assimilation rate and transpiration, as well as at concentrations from 0 to 160 µmol L-1 for stomatal conductance of plants irrigated with ECw of 2.0 dS m-1. Application of H2O2 via soil up to a concentration of 320 µmol L-1 increases the plant height, but reduces culm diameter of maize.
DOI: 10.6084/m9.figshare.20455058.v1
title: Physiology and growth of maize under salinity of water and application of hydrogen peroxide

description: ABSTRACT The salinity of irrigation water or soil is the abiotic factor that most negatively impacts the yield of crops, including green maize, so it is necessary to find alternatives to ensure production. In this context, this study aimed to evaluate gas exchange, photosynthetic pigments, and growth of maize under salinity of irrigation water and application of hydrogen peroxide. The experiment was conducted at the Center of Sciences and Agrifood Technology, Pombal, PB, belonging to the Federal University of Campina Grande, in the period from January to February 2015, using the maize hybrid ‘AG 1051’. The treatments consisted of two salinity levels of irrigation water (0.3 and 2.0 dS m-1) and five concentrations of hydrogen peroxide (0, 40, 80, 160, and 320 µmol L-1) applied via irrigation water. The experimental design was completely randomized, in a 2 × 5 factorial scheme, with four replicates. ECw of 2.0 dS m-1 reduces transpiration, stomatal conductance, total chlorophyll, carotenoids, and initial growth, but does not affect the dry mass accumulation of maize plants. Application of H2O2 via soil varying from 0 to 320 µmol L-1 causes reductions in the CO2 assimilation rate and transpiration, as well as at concentrations from 0 to 160 µmol L-1 for stomatal conductance of plants irrigated with ECw of 2.0 dS m-1. Application of H2O2 via soil up to a concentration of 320 µmol L-1 increases the plant height, but reduces culm diameter of maize.
DOI: 10.6084/m9.figshare.20455064
title: Direct-acting antivirals for chronic Hepatitis C are effective and safe: an observational study in Londrina/PR

description: Abstract This study aimed to evaluate the effectiveness and safety of direct-acting antivirals in a Unified Health System pharmacy of Londrina, Brazil. A descriptive observational study was performed from June 2017 to June 2018. Sociodemographic, clinical, and therapeutic variables of patients were collected from secondary data sources. Effectiveness was evaluated by sustained virologic response (SVR) and safety was evaluated by adverse events (AEs) and drug interactions (DIs). The mean population (N=30) was 56.6±11.3 years old and almost all patients had comorbidities (93.3%) and concomitant drugs (96.7%). Effectiveness evaluation was possible in 17 patients, and all of them (100.0%) achieved SVR. Eighteen patients (60.0%) reported 38 AEs, mostly mild, such as stomach symptoms and headache. No statistical relation was found between AE occurrence and treatment duration, Ribavirin use, number of comorbidities or number of concomitant drugs. A total of 48 DIs were reported, 18 being severe, and were managed by the pharmacist. The study indicates that the treatment was effective and safe.
DOI: 10.6084/m9.figshare.20455064.v1
title: Direct-acting antivirals for chronic Hepatitis C are effective and safe: an observational study in Londrina/PR

description: Abstract This study aimed to evaluate the effectiveness and safety of direct-acting antivirals in a Unified Health System pharmacy of Londrina, Brazil. A descriptive observational study was performed from June 2017 to June 2018. Sociodemographic, clinical, and therapeutic variables of patients were collected from secondary data sources. Effectiveness was evaluated by sustained virologic response (SVR) and safety was evaluated by adverse events (AEs) and drug interactions (DIs). The mean population (N=30) was 56.6±11.3 years old and almost all patients had comorbidities (93.3%) and concomitant drugs (96.7%). Effectiveness evaluation was possible in 17 patients, and all of them (100.0%) achieved SVR. Eighteen patients (60.0%) reported 38 AEs, mostly mild, such as stomach symptoms and headache. No statistical relation was found between AE occurrence and treatment duration, Ribavirin use, number of comorbidities or number of concomitant drugs. A total of 48 DIs were reported, 18 being severe, and were managed by the pharmacist. The study indicates that the treatment was effective and safe.