cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.7899926.v1
title: Relationship between uric acid levels and risk of chronic kidney disease in a retrospective cohort of Brazilian workers

description: Uric acid (UA) levels are increased in patients with kidney dysfunction. We analyzed the association between asymptomatic hyperuricemia and new-onset chronic kidney disease (CKD). A retrospective cohort study was designed to collect data from employees of an energy generation and distribution company in the city of Rio de Janeiro, Brazil, who had undergone the company’s annual medical checkup from 2008 to 2014. People with ≤2 years of follow-up, with baseline estimated glomerular filtration rate (eGFR) &lt;60 mL·min-1·(1.73 m2)-1 or with incomplete data were excluded. The endpoint was defined as eGFR &lt;60 mL·min-1·(1.73 m2)-1 estimated through the chronic kidney disease epidemiology collaboration equation (CKD-EPI). The study included 1094 participants. The mean follow-up period was 5.05±1.05 years and 44 participants exhibited new-onset CKD. The prevalence of hyperuricemia was 4.2%. There was a significant inverse correlation between baseline serum levels of UA and baseline eGFR (R=-0.21, P&lt;0.001). Female gender (OR=4.00; 95%CI=1.92-8.29, P&lt;0.001) and age (OR=1.06; 95%CI=1.02-1.11, P=0.004) but not UA levels (OR=1.12; 95%CI=0.83-1.50; P=0.465) were associated with new-onset CKD. Diabetes mellitus and body mass index were independent factors for fast progression (OR=2.17; 95%CI=1.24-3.80, P=0.007 and OR=1.04; 95%CI=1.01-1.07; P=0.020). These results did not support UA as an independent predictor for CKD progression in the studied population.
DOI: 10.6084/m9.figshare.7899905
title: Detection and differentiation of Entamoeba histolytica and Entamoeba dispar in clinical samples through PCR-denaturing gradient gel electrophoresis

description: Amebiasis is one of the twenty major causes of disease in Mexico; however, the diagnosis is difficult due to limitations of conventional microscopy-based techniques. In this study, we analyzed stool samples using polymerase chain reaction-denaturing gradient gel electrophoresis (PCR-DGGE) to differentiate between Entamoeba histolytica (pathogenic) and E. dispar (non-pathogenic). The target for the PCR amplification was a small region (228 bp) of the adh112 gene selected to increase the sensitivity of the test. The study involved 62 stool samples that were collected from individuals with complaints of gastrointestinal discomfort. Of the 62 samples, 10 (16.1%) were positive for E. histolytica while 52 (83.9%) were negative. No sample was positive for E. dispar. These results were validated by nested PCR-RFLP (restriction fragment length polymorphism) and suggest that PCR-DGGE is a promising tool to differentiate among Entamoeba infections, contributing to determine the specific treatment for patients infected with E. histolytica, and therefore, avoiding unnecessary treatment of patients infected with the non-pathogenic E. dispar.
DOI: 10.6084/m9.figshare.7899911
title: Leakage Resistance Envelopes of API 8 Round Casing Connections using FE Analysis

description: Abstract Leakage resistance of casing connections can be evaluated by extremely expensive testing procedures. Although testing is required for connection validation, significant amount of resources can be saved by complementing testing with Finite Element (FE) analysis. In this regard, a broadly accepted criterion to characterize leaks in FE simulation is still required. This paper proposes an objective and accurate criterion to characterize leakage resistance of casing connections in axisymmetric FE simulation. The criterion is based on stab flank contact pressures and stab flank engaged length parameters. The criterion is tested in application to API 8 Round LTC connections (5 ½ J55 14lb/ft), and confronted with test results. Leakage envelopes are obtained considering make-up torque and tensile axial loads. The influence of taper on connection sealability is also investigated. The long term goal of the investigation is to derive probabilistic leakage envelopes of casing connections considering manufacturing tolerances, effect of thermal cycles, and seal ovalization due to bending during assembly.
DOI: 10.6084/m9.figshare.7899914.v1
title: First report of antibodies to Neospora spp. in horses from Portugal

description: Abstract Neospora spp. are intracellular protozoa with worldwide distribution and closely related to Toxoplasma gondii, which can infect a variety of mammals including horses. From September 2013 to June 2014, 185 horses from northern, central and southern parts of mainland Portugal were randomly sampled and tested for detection of immunoglobulin (Ig) G antibodies to Neospora spp. using an indirect multi-species enzyme-linked immunosorbent assay (ELISA) commercial test (ID Screen® Neospora caninum Indirect Multi-species; ID.vet Innovative Diagnostics, Grabels, France). Two horses (1.1%; CI: 0.1-3.8%), one male and one female, were found to be seropositive for Neospora spp. Both seropositive animals were horses housed indoors but with access to outdoors, used for leisure activities and were apparently healthy, with good body condition and with no alterations at physical examination. This was the first serologic survey of antibodies to Neospora spp. carried out in horses from Portugal.
DOI: 10.6084/m9.figshare.7899920.v1
title: Association of metabolic syndrome with inflammatory markers in a sample of community-dwelling older adults

description: The study aimed to identify the cutoff points for inflammatory markers that best discriminate the occurrence of metabolic syndrome in community-dwelling older adults. Baseline data were used from the elderly cohort in the city of Bambuí, Minas Gerais State, Brazil. The target exposure was presence of metabolic syndrome, defined according to the Adult Treatment Panel III criterion, and the outcomes included the following inflammatory markers: cytokines (IL-1β, IL-6, IL-10, IL-12 e TNF), chemokines (CXCL8, CXCL9, CCL2, CXCL10, and CCL5), and C-reactive protein (CRP). Definition of the cutoff points for the inflammatory markers was based on the Classification and Regression Tree (CART) method. The associations between these markers and metabolic syndrome were estimated by logistic regression models, obtaining odds ratios and 95% confidence intervals, considering adjustment for confounding factors. Prevalence of metabolic syndrome was 49.1%, and IL-1β, IL-12, and TNF levels were not associated statistically with this exposure. After adjustment, presence of metabolic syndrome was associated with higher IL-6 and CRP levels and lower CXCL8 and CCL5. Significant associations were also observed with intermediate serum CXCL9 and CXCL10 levels. The combination of markers also showed a significant and consistent association with metabolic syndrome. In addition to demonstrating an association between metabolic syndrome and a wide range of biomarkers (some not previously described in the literature), the results highlight that this association occurs at much lower levels than previously demonstrated, suggesting that metabolic syndrome plays an important role in the inflammatory profile of the older adults.
DOI: 10.6084/m9.figshare.7899902
title: Numerical Study of the Circumferential Fuses Used in Steel Repairable Buildings with Seesaw Motion

description: Abstract Structural fuses and rocking system are used in order to reduce the building response to earthquakes and damage guidance. In the proposed seesaw motion system, which is similar to the rocking system, the building columns, in top of the foundation, have been removed and a central support and structural fuses are used around the building instead of them. The main purpose of creating this system is that the structural components remain elastic during the earthquake and nonlinear deformations occur in circumferential structural fuses it means that, it is possible to replace damaged fuses after the earthquake and exploit the building in a short time and at a lower cost than the construction cost of the whole building. In this research, the specification of a kind of structural fuse have been investigated and its application in the building with a seesaw system is studied under the influence of the near-field earthquake. After reviewing the fuses, it was observed that, the maximum absolute acceleration of roof and the base shear are significantly reduced in this system; however, the relative drift of floors in some buildings has increased but is lower than the permitted limit.
DOI: 10.6084/m9.figshare.7899911.v1
title: Leakage Resistance Envelopes of API 8 Round Casing Connections using FE Analysis

description: Abstract Leakage resistance of casing connections can be evaluated by extremely expensive testing procedures. Although testing is required for connection validation, significant amount of resources can be saved by complementing testing with Finite Element (FE) analysis. In this regard, a broadly accepted criterion to characterize leaks in FE simulation is still required. This paper proposes an objective and accurate criterion to characterize leakage resistance of casing connections in axisymmetric FE simulation. The criterion is based on stab flank contact pressures and stab flank engaged length parameters. The criterion is tested in application to API 8 Round LTC connections (5 ½ J55 14lb/ft), and confronted with test results. Leakage envelopes are obtained considering make-up torque and tensile axial loads. The influence of taper on connection sealability is also investigated. The long term goal of the investigation is to derive probabilistic leakage envelopes of casing connections considering manufacturing tolerances, effect of thermal cycles, and seal ovalization due to bending during assembly.
DOI: 10.6084/m9.figshare.7899896
title: Experimental investigation of bolted stiffened end-plate and bolted flange-plate connections

description: Abstract This paper describes the experimental performance of the bolted stiffened end-plate (BSEP) and bolted flange-plate (BFP) connections using European hot-rolled profiles and built-up profiles. Four connections are designed and constructed according to FEMA-350 and are performed under cyclic loading. The influence of using different member profiles (European profiles and built-up profiles) in both the BSEP and BFP connections are examined. The obtained test results, including failure modes, hysteretic curves, ultimate moment and rotation values and panel zone extensions were reported and the performance of different connections is compared. It was found out, based on the obtained test results, that using hot-rolled or built-up profiles in the connection does not affect its global behavior.
DOI: 10.6084/m9.figshare.7899899
title: Effect of RAP content on flexural behavior and fracture toughness of flexible pavement

description: Abstract The use of recycled Reclaimed Asphalt Pavement (RAP) material into flexible pavement contributes to sustainable development with environmental and economic benefits. In the present work, Semi-Circular Bending (SCB) specimen has been adopted to study the flexural strength and mode-I fracture toughness of flexible pavement with and without RAP. Two different resources of RAP, namely KS and KF, with two different percentages (20% and 40%) have been examined. Smooth and cracked specimens have been cast to measure the flexural strength and mode-I fracture of flexible pavement containing RAP, respectively. Smooth and cracked specimens for flexible pavement without RAP, as control beams, have been cast for the sake of comparisons. The experimental results showed that, the flexural strength and mode-I fracture toughness of flexible pavement containing 40% RAP are higher than those of flexible pavement without RAP, for the two types of RAP. Comparison between the of work of fracture calculated based on AASHTO TP 105-13 and AASHTO TP 124-16 showed that, the calculation based on AASHTO TP 105-13 is more accurate than that based on AASHTO TP 124-16. Furthermore, the suggested quad-linear relation to work of fracture predictions is easier and more reasonable for presenting the experimental results especially for the descending part of P-LLD curve than that suggested as exponential curve by AASHTO TP 124-16. For all groups, the type of failure is intergranular-mode fracture.
DOI: 10.6084/m9.figshare.7899902.v1
title: Numerical Study of the Circumferential Fuses Used in Steel Repairable Buildings with Seesaw Motion

description: Abstract Structural fuses and rocking system are used in order to reduce the building response to earthquakes and damage guidance. In the proposed seesaw motion system, which is similar to the rocking system, the building columns, in top of the foundation, have been removed and a central support and structural fuses are used around the building instead of them. The main purpose of creating this system is that the structural components remain elastic during the earthquake and nonlinear deformations occur in circumferential structural fuses it means that, it is possible to replace damaged fuses after the earthquake and exploit the building in a short time and at a lower cost than the construction cost of the whole building. In this research, the specification of a kind of structural fuse have been investigated and its application in the building with a seesaw system is studied under the influence of the near-field earthquake. After reviewing the fuses, it was observed that, the maximum absolute acceleration of roof and the base shear are significantly reduced in this system; however, the relative drift of floors in some buildings has increased but is lower than the permitted limit.
DOI: 10.6084/m9.figshare.7899905.v1
title: Detection and differentiation of Entamoeba histolytica and Entamoeba dispar in clinical samples through PCR-denaturing gradient gel electrophoresis

description: Amebiasis is one of the twenty major causes of disease in Mexico; however, the diagnosis is difficult due to limitations of conventional microscopy-based techniques. In this study, we analyzed stool samples using polymerase chain reaction-denaturing gradient gel electrophoresis (PCR-DGGE) to differentiate between Entamoeba histolytica (pathogenic) and E. dispar (non-pathogenic). The target for the PCR amplification was a small region (228 bp) of the adh112 gene selected to increase the sensitivity of the test. The study involved 62 stool samples that were collected from individuals with complaints of gastrointestinal discomfort. Of the 62 samples, 10 (16.1%) were positive for E. histolytica while 52 (83.9%) were negative. No sample was positive for E. dispar. These results were validated by nested PCR-RFLP (restriction fragment length polymorphism) and suggest that PCR-DGGE is a promising tool to differentiate among Entamoeba infections, contributing to determine the specific treatment for patients infected with E. histolytica, and therefore, avoiding unnecessary treatment of patients infected with the non-pathogenic E. dispar.
DOI: 10.6084/m9.figshare.7899887
title: Association of exercise training and angiotensin-converting enzyme 2 activator improves baroreflex sensitivity of spontaneously hypertensive rats

description: The present study sought to determine cardiovascular effects of aerobic training associated with diminazene aceturate (DIZE), an activator of the angiotensin converting enzyme 2, in spontaneously hypertensive rats (SHRs). Male SHRs (280–350 g) were either subjected to exercise training or not (sedentary group). The trained group was subjected to 8 weeks of aerobic training on a treadmill (five times a week, lasting 60 min at an intensity of 50–60% of maximum aerobic speed). In the last 15 days of the experimental protocol, these groups were redistributed into four groups: i) sedentary SHRs with daily treatment of 1 mg/kg DIZE (S+D1); ii) trained SHRs with daily treatment of 1 mg/kg DIZE (T+D1); iii) sedentary SHRs with daily treatment of vehicle (S+V); and iv) trained SHRs with daily treatment of vehicle (T+V). After treatment, SHRs were anesthetized and subjected to artery and femoral vein cannulation prior to the implantation of ECG electrode. After 24 h, mean arterial pressure (MAP) and heart rate (HR) were recorded; the baroreflex sensitivity and the effect of double autonomic blockade (DAB) were evaluated in non-anesthetized SHRs. DIZE treatment improved baroreflex sensitivity in the T+D1 group as compared with the T+V and S+D1 groups. The intrinsic heart rate (IHR) and MAP were reduced in T+D1 group as compared with T+V and S+D1 groups. Hence, we conclude that the association of exercise training with DIZE treatment improved baroreflex function and cardiovascular regulation.
DOI: 10.6084/m9.figshare.7899890
title: Comparison of conventional Papanicolaou cytology samples with liquid-based cervical cytology samples from women in Pernambuco, Brazil

description: In the present study, we compared the performance of a ThinPrep cytological method with the conventional Papanicolaou test for diagnosis of cytopathological changes, with regard to unsatisfactory results achieved at the Central Public Health Laboratory of the State of Pernambuco. A population-based, cross-sectional study was performed with women aged 18 to 65 years, who spontaneously sought gynecological services in Public Health Units in the State of Pernambuco, Northeast Brazil, between April and November 2011. All patients in the study were given a standardized questionnaire on sociodemographics, sexual characteristics, reproductive practices, and habits. A total of 525 patients were assessed by the two methods (11.05% were under the age of 25 years, 30.86% were single, 4.4% had had more than 5 sexual partners, 44% were not using contraception, 38.85% were users of alcohol, 24.38% were smokers, 3.24% had consumed drugs previously, 42.01% had gynecological complaints, and 12.19% had an early history of sexually transmitted diseases). The two methods showed poor correlation (k=0.19; 95%CI=0.11–0.26; P&lt;0.001). The ThinPrep method reduced the rate of unsatisfactory results from 4.38% to 1.71% (χ2=5.28; P=0.02), and the number of cytopathological changes diagnosed increased from 2.47% to 3.04%. This study confirmed that adopting the ThinPrep method for diagnosis of cervical cytological samples was an improvement over the conventional method. Furthermore, this method may reduce possible losses from cytological resampling and reduce obstacles to patient follow-up, improving the quality of the public health system in the State of Pernambuco, Northeast Brazil.
DOI: 10.6084/m9.figshare.7899896.v1
title: Experimental investigation of bolted stiffened end-plate and bolted flange-plate connections

description: Abstract This paper describes the experimental performance of the bolted stiffened end-plate (BSEP) and bolted flange-plate (BFP) connections using European hot-rolled profiles and built-up profiles. Four connections are designed and constructed according to FEMA-350 and are performed under cyclic loading. The influence of using different member profiles (European profiles and built-up profiles) in both the BSEP and BFP connections are examined. The obtained test results, including failure modes, hysteretic curves, ultimate moment and rotation values and panel zone extensions were reported and the performance of different connections is compared. It was found out, based on the obtained test results, that using hot-rolled or built-up profiles in the connection does not affect its global behavior.
DOI: 10.6084/m9.figshare.7899899.v1
title: Effect of RAP content on flexural behavior and fracture toughness of flexible pavement

description: Abstract The use of recycled Reclaimed Asphalt Pavement (RAP) material into flexible pavement contributes to sustainable development with environmental and economic benefits. In the present work, Semi-Circular Bending (SCB) specimen has been adopted to study the flexural strength and mode-I fracture toughness of flexible pavement with and without RAP. Two different resources of RAP, namely KS and KF, with two different percentages (20% and 40%) have been examined. Smooth and cracked specimens have been cast to measure the flexural strength and mode-I fracture of flexible pavement containing RAP, respectively. Smooth and cracked specimens for flexible pavement without RAP, as control beams, have been cast for the sake of comparisons. The experimental results showed that, the flexural strength and mode-I fracture toughness of flexible pavement containing 40% RAP are higher than those of flexible pavement without RAP, for the two types of RAP. Comparison between the of work of fracture calculated based on AASHTO TP 105-13 and AASHTO TP 124-16 showed that, the calculation based on AASHTO TP 105-13 is more accurate than that based on AASHTO TP 124-16. Furthermore, the suggested quad-linear relation to work of fracture predictions is easier and more reasonable for presenting the experimental results especially for the descending part of P-LLD curve than that suggested as exponential curve by AASHTO TP 124-16. For all groups, the type of failure is intergranular-mode fracture.
DOI: 10.6084/m9.figshare.7899878
title: Grain yield, efficiency and the allocation of foliar N applied to soybean canopies

description: ABSTRACT: Soybean [Glycine max (L.) Merr.] grain yield is closely associated with the level of optimal nitrogen (N) supply, especially during the reproductive stages. Foliar fertilization with low rates of N have been considered as a strategy for furnishing additional N and enhancing grain yields. Field studies using 15N tracer were conducted over two growing seasons to investigate the impact of foliar N fertilization on grain yield, plant N content, the amount of N derived from fertilizer (NDFF) and N recovery efficiency (NRE). Four foliar N rates (0, 1300, 2600 and 3900 g ha−1) were supplied by two equal split applications at the R1 and R3 stages. Foliar N fertilization of soybean canopies did not affect grain yield, grain N content, shoot N content nor plant N content. Total NDFF was increased from 0.7 to 2.0 kg ha−1 across the N rates. Nonetheless, NRE was unaffected by foliar N fertilization, which averaged 53 %. Soybean plants allocated the same amount of N fertilizer to both grains and shoots. No significant effects of low rate foliar N fertilization were registered on soybean grain yield nor plant N content, despite considerable N fertilizer recovery by plant organs.
DOI: 10.6084/m9.figshare.7899881
title: Anthelmintic resistance of injectable macrocyclic lactones in cattle: A systematic review and meta-analysis

description: Abstract The purpose of this work was to identify, critically assess, and summarize available data from primary research about the anthelmintic resistance of injectable macrocyclic lactones in cattle. Meta-analysis was performed to estimate the pooled Odds Ratio and 95% Confidence Intervals. Of the 1504 abstracts screened for eligibility, 80 were deemed relevant for full publication review. Thirteen publications were included in the qualitative synthesis and assessed for systematic bias. Only five studies were included in the quantitative analysis because they showed a low risk of producing biased results in all the parameters. The forest plot indicated four studies that discuss anthelmintic resistance (P&lt;0.05), while only one study did not discuss anthelmintic resistance (P&lt;0.05). The pooled estimate showed 0.59 (95% Confidence intervals: 0.08, 0.47) times higher odds for studies that report anthelmintic resistance than for studies reporting efficacious anthelmintic treatment, with significant and substantially low heterogeneity (I2=25%). Anthelmintic resistance to injectable macrocyclic lactones is a reality. There are need to improve methodological reporting in studies, which is a problem for investigations that involves systematic review and meta-analysis (SR-MA).