cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.6730991.v1
title: Mitochondrial Regulation of [Ca<sup>2+</sup>]i Oscillations During Cell Cycle Resumption of the Second Meiosis of Oocyte

description: Oocyte is arrested at metaphase of the second meiosis until fertilization switching on [Ca<sup>2+</sup>]i oscillations. Oocyte activation inefficiency is the most challenging problem for failed fertilization and embryonic development. Mitochondrial function and intracellular [Ca<sup>2+</sup>]i oscillations are two critical factors for the oocyte’s developmental potential. We aimed to understand the possible correlation between mitochondrial function and [Ca<sup>2+</sup>]i oscillations in oocytes. To this end, mitochondrial uncoupler CCCP which damages mitochondrial function and two small molecule mitochondrial agonists, L-carnitine (LC) and BGP-15, were used to examine the regulation of [Ca<sup>2+</sup>]i by mitochondrial functions. With increasing CCCP concentrations, [Ca<sup>2+</sup>]i oscillations were gradually diminished and high concentrations of CCCP led to oocyte death. LC enhanced mitochondrial membrane potential and [Ca<sup>2+</sup>]i oscillations and even improved the damage induced by CCCP, however, BGP-15 had no beneficial effect on oocyte activation. We have found that mitochondrial function plays a vital role in the generation of [Ca<sup>2+</sup>]i oscillations in oocytes, and thus mitochondria may interact with the ER to generate [Ca<sup>2+</sup>]i oscillations during oocyte activation. Improvement of mitochondrial functions with small molecules can be expected to improve oocyte activation and embryonic development in infertile patients without invasive micromanipulation.
DOI: 10.6084/m9.figshare.6730994
title: Oncogene-dependent addiction to carbohydrate-responsive element binding protein in hepatocellular carcinoma

description: Metabolic reprogramming is a hallmark of many cancer types, including hepatocellular carcinoma (HCC). Identifying the critical players in this process might be crucial for the generation of novel and effective anti-neoplastic therapies. In the present investigation, we determined the importance of carbohydrate responsive element binding protein (ChREBP), a central player in the regulation of lipid and glucose metabolism in the liver, on the development of HCC in <i>in vitro</i> and <i>in vivo</i> models. We found that genetic deletion of ChREBP (that will be referred to as ChREBPKO mice) strongly delays or impairs hepatocarcinogenesis driven by AKT or AKT/c-Met overexpression in mice, respectively. In contrast, HCC development was found to be completely unaffected by ChREBP depletion in mice co-expressing AKT and N-Ras protooncogenes. In mouse and human HCC cell lines, suppression of ChREBP via specific small interfering RNAs (siRNAs) resulted in decreased proliferation and induction of apoptosis. Of note, these cellular events were strongly augmented by concomitant inhibition of the mitogen-activated protein kinase (MAPK) pathway. The present data indicate that ChREBP activity might be required or dispensable for HCC growth, depending on the oncogenes involved. In particular, the activation of Ras/MAPK signaling might represent a possible mechanism of resistance to ChREBP depletion in this tumor type. Additional studies are needed to unravel the molecular mechanisms rendering HCC cells insensitive to ChREBP suppression.
DOI: 10.6084/m9.figshare.6730994.v2
title: Oncogene-dependent addiction to carbohydrate-responsive element binding protein in hepatocellular carcinoma

description: Metabolic reprogramming is a hallmark of many cancer types, including hepatocellular carcinoma (HCC). Identifying the critical players in this process might be crucial for the generation of novel and effective anti-neoplastic therapies. In the present investigation, we determined the importance of carbohydrate responsive element binding protein (ChREBP), a central player in the regulation of lipid and glucose metabolism in the liver, on the development of HCC in <i>in vitro</i> and <i>in vivo</i> models. We found that genetic deletion of ChREBP (that will be referred to as ChREBPKO mice) strongly delays or impairs hepatocarcinogenesis driven by AKT or AKT/c-Met overexpression in mice, respectively. In contrast, HCC development was found to be completely unaffected by ChREBP depletion in mice co-expressing AKT and N-Ras protooncogenes. In mouse and human HCC cell lines, suppression of ChREBP via specific small interfering RNAs (siRNAs) resulted in decreased proliferation and induction of apoptosis. Of note, these cellular events were strongly augmented by concomitant inhibition of the mitogen-activated protein kinase (MAPK) pathway. The present data indicate that ChREBP activity might be required or dispensable for HCC growth, depending on the oncogenes involved. In particular, the activation of Ras/MAPK signaling might represent a possible mechanism of resistance to ChREBP depletion in this tumor type. Additional studies are needed to unravel the molecular mechanisms rendering HCC cells insensitive to ChREBP suppression.
DOI: 10.6084/m9.figshare.6730994.v1
title: Oncogene-dependent addiction to Carbohydrate-Responsive Element Binding Protein in hepatocellular carcinoma

description: Metabolic reprogramming is a hallmark of many cancer types, including hepatocellular carcinoma (HCC). Identifying the critical players in this process might be crucial for the generation of novel and effective anti-neoplastic therapies. In the present investigation, we determined the importance of carbohydrate responsive element binding protein (ChREBP), a central player in the regulation of lipid and glucose metabolism in the liver, on the development of HCC in <i>in vitro</i> and <i>in vivo</i> models. We found that genetic deletion of ChREBP (that will be referred to as ChREBPKO mice) strongly delays or impairs hepatocarcinogenesis driven by AKT or AKT/c-Met overexpression in mice, respectively. In contrast, HCC development was found to be completely unaffected by ChREBP depletion in mice co-expressing AKT and N-Ras protooncogenes. In mouse and human HCC cell lines, suppression of ChREBP via specific small interfering RNAs (siRNAs) resulted in decreased proliferation and induction of apoptosis. Of note, these cellular events were strongly augmented by concomitant inhibition of the mitogen-activated protein kinase (MAPK) pathway. The present data indicate that ChREBP activity might be required or dispensable for HCC growth, depending on the oncogenes involved. In particular, the activation of Ras/MAPK signaling might represent a possible mechanism of resistance to ChREBP depletion in this tumor type. Additional studies are needed to unravel the molecular mechanisms rendering HCC cells insensitive to ChREBP suppression.
DOI: 10.15468/4pfq8p
title: Untersuchungen zur Isopodenfauna (Unterordnung Oniscoidea) verschiedener Habitattypen von Bergbaufolgelandschaften und des Umlandes im Land Sachsen-Anhalt

description: This dataset is part of Edaphobase. Edaphobase is a data warehouse that collects information from literature, museum collections and research data about the distribution and ecology of soil organisms (earthworms, potworms, nematodes, springtails, proturans, diplurans, moss/beetle mites, gamasina mites, centipedes, millipedes, woodlice, soil fungi and soil prokaryotes). You can discover the whole Edaphobase data here: https://portal.edaphobase.org/ To get more information about Edaphobase please go to: https://edaphobase.org/ Data ownersS. Bergmann Discover the datahttps://portal.edaphobase.org/?qxenv:action:gbif&qxenv:sources:238381
DOI: 10.15468/ppbjw4
title: SMNG_Myriapoda_Lüneburger Heide

description: This dataset is part of Edaphobase. Edaphobase is a data warehouse that collects information from literature, museum collections and research data about the distribution and ecology of soil organisms (earthworms, potworms, nematodes, springtails, proturans, diplurans, moss/beetle mites, gamasina mites, centipedes, millipedes, woodlice, soil fungi and soil prokaryotes). You can discover the whole Edaphobase data here: https://portal.edaphobase.org/ To get more information about Edaphobase please go to: https://edaphobase.org/ Discover the datahttps://portal.edaphobase.org/?qxenv:action:gbif&qxenv:sources:72612
DOI: 10.14284/584
title: LifeWatch observatory data: zooplankton observations by imaging (ZooScan) in the Belgian Part of the North Sea

description: In the framework of the Lifewatch marine observatory a number of fixed stations on the Belgian Part of the North Sea (BPNS) are visited on a monthly or seasonal basis using the RV Simon Stevin. A grid of nine stations covers the coastal zone and are sampled monthly. Eight additional stations, located further at sea, are sampled on a seasonal basis. This dataset contains zooplankton observations in the Belgian Part of the North Sea (BPNS) since 2012. Zooplankton is sampled by vertical WP2 net tows, samples scanned with ZooScanner and identification with plankton analyser software, followed by manual validation.
DOI: 10.15468/3db45d
title: SMNG_Myriapoda_Neißetal - 1977 - 1990

description: This dataset is part of Edaphobase. Edaphobase is a data warehouse that collects information from literature, museum collections and research data about the distribution and ecology of soil organisms (earthworms, potworms, nematodes, springtails, proturans, diplurans, moss/beetle mites, gamasina mites, centipedes, millipedes, woodlice, soil fungi and soil prokaryotes). You can discover the whole Edaphobase data here: https://portal.edaphobase.org/ To get more information about Edaphobase please go to: https://edaphobase.org/ Discover the datahttps://portal.edaphobase.org/?qxenv:action:gbif&qxenv:sources:42995
DOI: 10.15468/guq3e9
title: Kinzigaue. Zoologische Untersuchungen 1999-2001, Teil 1. Naturwaldreservate in Hessen

description: This dataset is part of Edaphobase. Edaphobase is a data warehouse that collects information from literature, museum collections and research data about the distribution and ecology of soil organisms (earthworms, potworms, nematodes, springtails, proturans, diplurans, moss/beetle mites, gamasina mites, centipedes, millipedes, woodlice, soil fungi and soil prokaryotes). You can discover the whole Edaphobase data here: https://portal.edaphobase.org/ To get more information about Edaphobase please go to: https://edaphobase.org/ Data ownersJörg Römbke, Theo Blick, Wolfgang H.O. Dorow Discover the datahttps://portal.edaphobase.org/?qxenv:action:gbif&qxenv:sources:278473
DOI: 10.15468/cyyc2r
title: Festschrift für Zschokke.

description: This dataset is part of Edaphobase. Edaphobase is a data warehouse that collects information from literature, museum collections and research data about the distribution and ecology of soil organisms (earthworms, potworms, nematodes, springtails, proturans, diplurans, moss/beetle mites, gamasina mites, centipedes, millipedes, woodlice, soil fungi and soil prokaryotes). You can discover the whole Edaphobase data here: https://portal.edaphobase.org/ To get more information about Edaphobase please go to: https://edaphobase.org/ Data ownersWalter Bigler Discover the datahttps://portal.edaphobase.org/?qxenv:action:gbif&qxenv:sources:27844
DOI: 10.15468/u6empf
title: SMNG_Lumbricidae_Bodendauerbeobachtungsflächen Sachsen-Anhalt_BDF 2013

description: This dataset is part of Edaphobase. Edaphobase is a data warehouse that collects information from literature, museum collections and research data about the distribution and ecology of soil organisms (earthworms, potworms, nematodes, springtails, proturans, diplurans, moss/beetle mites, gamasina mites, centipedes, millipedes, woodlice, soil fungi and soil prokaryotes). You can discover the whole Edaphobase data here: https://portal.edaphobase.org/ To get more information about Edaphobase please go to: https://edaphobase.org/ Discover the datahttps://portal.edaphobase.org/?qxenv:action:gbif&qxenv:sources:332893 Description of this datasetRegenwürmer auf ausgewählten Boden-Dauerbeobachtungsflächen (BDF) in Sachsen-Anhalt.
DOI: 10.15468/u6whwf
title: Tausendfüßler oder Myriapoda

description: This dataset is part of Edaphobase. Edaphobase is a data warehouse that collects information from literature, museum collections and research data about the distribution and ecology of soil organisms (earthworms, potworms, nematodes, springtails, proturans, diplurans, moss/beetle mites, gamasina mites, centipedes, millipedes, woodlice, soil fungi and soil prokaryotes). You can discover the whole Edaphobase data here: https://portal.edaphobase.org/ To get more information about Edaphobase please go to: https://edaphobase.org/ Data ownersOtto Schubart Discover the datahttps://portal.edaphobase.org/?qxenv:action:gbif&qxenv:sources:23014
DOI: 10.15468/un6eum
title: SMNG_Myriapoda_Brocken

description: This dataset is part of Edaphobase. Edaphobase is a data warehouse that collects information from literature, museum collections and research data about the distribution and ecology of soil organisms (earthworms, potworms, nematodes, springtails, proturans, diplurans, moss/beetle mites, gamasina mites, centipedes, millipedes, woodlice, soil fungi and soil prokaryotes). You can discover the whole Edaphobase data here: https://portal.edaphobase.org/ To get more information about Edaphobase please go to: https://edaphobase.org/ Discover the datahttps://portal.edaphobase.org/?qxenv:action:gbif&qxenv:sources:34136
DOI: 10.15468/c6yh9c
title: SMNG_Myriapoda_Ansorge

description: This dataset is part of Edaphobase. Edaphobase is a data warehouse that collects information from literature, museum collections and research data about the distribution and ecology of soil organisms (earthworms, potworms, nematodes, springtails, proturans, diplurans, moss/beetle mites, gamasina mites, centipedes, millipedes, woodlice, soil fungi and soil prokaryotes). You can discover the whole Edaphobase data here: https://portal.edaphobase.org/ To get more information about Edaphobase please go to: https://edaphobase.org/ Discover the datahttps://portal.edaphobase.org/?qxenv:action:gbif&qxenv:sources:33081
DOI: 10.15468/wdzk8p
title: Beeinträchtigung des Bodens als Filter und Puffer für Schadstoffe gegenüber endogäischen Regenwürmern

description: This dataset is part of Edaphobase. Edaphobase is a data warehouse that collects information from literature, museum collections and research data about the distribution and ecology of soil organisms (earthworms, potworms, nematodes, springtails, proturans, diplurans, moss/beetle mites, gamasina mites, centipedes, millipedes, woodlice, soil fungi and soil prokaryotes). You can discover the whole Edaphobase data here: https://portal.edaphobase.org/ To get more information about Edaphobase please go to: https://edaphobase.org/ Data ownersE. Belotti Discover the datahttps://portal.edaphobase.org/?qxenv:action:gbif&qxenv:sources:204756
DOI: 10.15468/5qgbm2
title: Die Enchytraeen eines Moderbuchenwaldes. Ihre Rolle beim Streuabbau und ihre Reaktion auf Umweltbelastungen

description: This dataset is part of Edaphobase. Edaphobase is a data warehouse that collects information from literature, museum collections and research data about the distribution and ecology of soil organisms (earthworms, potworms, nematodes, springtails, proturans, diplurans, moss/beetle mites, gamasina mites, centipedes, millipedes, woodlice, soil fungi and soil prokaryotes). You can discover the whole Edaphobase data here: https://portal.edaphobase.org/ To get more information about Edaphobase please go to: https://edaphobase.org/ Data ownersJörg Römbke Discover the datahttps://portal.edaphobase.org/?qxenv:action:gbif&qxenv:sources:204743
DOI: 10.15468/z2n9v8
title: Oribatida Sonnenberger Moor

description: This dataset is part of Edaphobase. Edaphobase is a data warehouse that collects information from literature, museum collections and research data about the distribution and ecology of soil organisms (earthworms, potworms, nematodes, springtails, proturans, diplurans, moss/beetle mites, gamasina mites, centipedes, millipedes, woodlice, soil fungi and soil prokaryotes). You can discover the whole Edaphobase data here: https://portal.edaphobase.org/ To get more information about Edaphobase please go to: https://edaphobase.org/ Data ownersRicarda Lehmitz Discover the datahttps://portal.edaphobase.org/?qxenv:action:gbif&qxenv:sources:315579
DOI: 10.15468/etgx77
title: Geoökologische Untersuchungen in Ackerökosystemen unterschiedlicher Maisanbauverfahren und ihre Verknüpfungen mit der Besatzdichte der Collembolen und Acarina (speziell Gamasina)

description: This dataset is part of Edaphobase. Edaphobase is a data warehouse that collects information from literature, museum collections and research data about the distribution and ecology of soil organisms (earthworms, potworms, nematodes, springtails, proturans, diplurans, moss/beetle mites, gamasina mites, centipedes, millipedes, woodlice, soil fungi and soil prokaryotes). You can discover the whole Edaphobase data here: https://portal.edaphobase.org/ To get more information about Edaphobase please go to: https://edaphobase.org/ Data ownersKarl-Hermann Knapmeyer Discover the datahttps://portal.edaphobase.org/?qxenv:action:gbif&qxenv:sources:106199
DOI: 10.15468/q53jk7
title: Ökologische Untersuchungen an Enchytraeiden (Oligochaeta) unterschiedlich saurer Buchenwälder des Eggegebirges

description: This dataset is part of Edaphobase. Edaphobase is a data warehouse that collects information from literature, museum collections and research data about the distribution and ecology of soil organisms (earthworms, potworms, nematodes, springtails, proturans, diplurans, moss/beetle mites, gamasina mites, centipedes, millipedes, woodlice, soil fungi and soil prokaryotes). You can discover the whole Edaphobase data here: https://portal.edaphobase.org/ To get more information about Edaphobase please go to: https://edaphobase.org/ Data ownersJoachim Schoch-Bösken Discover the datahttps://portal.edaphobase.org/?qxenv:action:gbif&qxenv:sources:204746
DOI: 10.15468/deugr5
title: Lumbriciden 2013. Regenwürmer auf ausgewählten Boden-Dauerbeobachtungsflächen (BDF) in Sachsen-Anhalt

description: This dataset is part of Edaphobase. Edaphobase is a data warehouse that collects information from literature, museum collections and research data about the distribution and ecology of soil organisms (earthworms, potworms, nematodes, springtails, proturans, diplurans, moss/beetle mites, gamasina mites, centipedes, millipedes, woodlice, soil fungi and soil prokaryotes). You can discover the whole Edaphobase data here: https://portal.edaphobase.org/ To get more information about Edaphobase please go to: https://edaphobase.org/ Data ownersElisabeth Neubert Discover the datahttps://portal.edaphobase.org/?qxenv:action:gbif&qxenv:sources:260408
DOI: 10.6084/m9.figshare.11449692
title: Terahertz spectroscopy of amino acid crystals based on dispersion-correction functional theory

description: The terahertz spectra of solid-state amino acids with different polarities were measured by terahertz time-domain spectroscopy and Fourier transform infrared spectroscopy. The measured absorption spectra were in good agreement with the results simulated by density functional theory using hybrid functional Becke–3–Lee–Yang–Parr and generalized-gradient approximation Perdew–Burke–Ernzerhof functional with the same basis set of 6-311 G (d, p), respectively. In order to construct a precise crystal structure, dispersion-corrected density functionals were included in the simulation. It was found that Becke–3–Lee–Yang–Parr functional combined with dispersion-correction could produce accurate simulation results that corresponded to the experimental terahertz spectra of solid-state amino acids. However, it greatly increased the time for calculation. The method of Perdew–Burke–Ernzerhof functional with dispersion-correction provided comparable accuracy to Becke–3–Lee–Yang–Parr with dispersion-correction, and much higher simulation speed. The spectral features are assigned as primarily external lattice translations and rotations with lesser contributions to intramolecular torsions.
DOI: 10.15468/gb5ctm
title: Projet de création du parc photovoltaïque au sol d'Eguzon-Chantôme-Inventaire des amphibiens

description: Inventaire des amphibiens sur un cycle biologique (une année) par des passages nocturnes et diurnes
DOI: 10.15468/5tz8m7
title: SMNG_Myriapoda_Ibisch

description: This dataset is part of Edaphobase. Edaphobase is a data warehouse that collects information from literature, museum collections and research data about the distribution and ecology of soil organisms (earthworms, potworms, nematodes, springtails, proturans, diplurans, moss/beetle mites, gamasina mites, centipedes, millipedes, woodlice, soil fungi and soil prokaryotes). You can discover the whole Edaphobase data here: https://portal.edaphobase.org/ To get more information about Edaphobase please go to: https://edaphobase.org/ Discover the datahttps://portal.edaphobase.org/?qxenv:action:gbif&qxenv:sources:69034
DOI: 10.6084/m9.figshare.11449692.v1
title: Terahertz spectroscopy of amino acid crystals based on dispersion-correction functional theory

description: The terahertz spectra of solid-state amino acids with different polarities were measured by terahertz time-domain spectroscopy and Fourier transform infrared spectroscopy. The measured absorption spectra were in good agreement with the results simulated by density functional theory using hybrid functional Becke–3–Lee–Yang–Parr and generalized-gradient approximation Perdew–Burke–Ernzerhof functional with the same basis set of 6-311 G (d, p), respectively. In order to construct a precise crystal structure, dispersion-corrected density functionals were included in the simulation. It was found that Becke–3–Lee–Yang–Parr functional combined with dispersion-correction could produce accurate simulation results that corresponded to the experimental terahertz spectra of solid-state amino acids. However, it greatly increased the time for calculation. The method of Perdew–Burke–Ernzerhof functional with dispersion-correction provided comparable accuracy to Becke–3–Lee–Yang–Parr with dispersion-correction, and much higher simulation speed. The spectral features are assigned as primarily external lattice translations and rotations with lesser contributions to intramolecular torsions.
DOI: 10.15468/3zvtyh
title: Bodenfauna und Umwelt - Bodenökologische Inventur und Beurteilung von ausgewählten Standorten in Baden-Württemberg

description: This dataset is part of Edaphobase. Edaphobase is a data warehouse that collects information from literature, museum collections and research data about the distribution and ecology of soil organisms (earthworms, potworms, nematodes, springtails, proturans, diplurans, moss/beetle mites, gamasina mites, centipedes, millipedes, woodlice, soil fungi and soil prokaryotes). You can discover the whole Edaphobase data here: https://portal.edaphobase.org/ To get more information about Edaphobase please go to: https://edaphobase.org/ Data ownersAndrea Ruf, Jörg Römbke, Jörg Spelda, Ludwig Beck, M. Scheurig, R. Paulus, Steffen Woas Discover the datahttps://portal.edaphobase.org/?qxenv:action:gbif&qxenv:sources:124290
DOI: 10.15468/9z7cx3
title: Erfassung des Biotop- und Artenpotentials auf dem Muschelkalkplateau oberhalb Winzerlas

description: This dataset is part of Edaphobase. Edaphobase is a data warehouse that collects information from literature, museum collections and research data about the distribution and ecology of soil organisms (earthworms, potworms, nematodes, springtails, proturans, diplurans, moss/beetle mites, gamasina mites, centipedes, millipedes, woodlice, soil fungi and soil prokaryotes). You can discover the whole Edaphobase data here: https://portal.edaphobase.org/ To get more information about Edaphobase please go to: https://edaphobase.org/ Data ownersHans-Ulrich Peter Discover the datahttps://portal.edaphobase.org/?qxenv:action:gbif&qxenv:sources:95850