cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.17021921
title: Supplementary Material for: Clinical Utility of the Electrocardiographic P-Wave Axis in Patients with Chronic Obstructive Pulmonary Disease

description: <b><i>Background:</i></b> The vertical P-wave axis on electrocardiography (ECG) is a useful criterion for screening patients with chronic obstructive pulmonary disease (COPD). This study aimed to investigate the clinical characteristics of patients with COPD with a vertical P-wave axis as they have not yet been elucidated. <b><i>Methods:</i></b> Keio University and its affiliated hospitals conducted an observational COPD cohort study over 3 years. We analyzed 201 patients using ECG and chest computed tomography. <b><i>Results:</i></b> The severity of airflow limitation was higher in patients with a P-wave axis &gt;75° than in those with a P-wave axis ≤75°. Patients with a P-wave axis &gt;75° exhibited significantly higher total COPD assessment test scores and increased St. George’s Respiratory Questionnaire total, activity, and impact scores than those with a P-wave axis ≤75°. The incidence of exacerbations over 1 and 3 years was significantly higher in patients with a P-wave axis &gt;75° than in those with a P-wave axis ≤75°. The optimal cutoff for the P-wave axis for a percentage of the predicted forced expiratory volume in 1 s &lt;50% and future exacerbations over 3 years was 70° (the areas under the curve [AUC]: 0.788; sensitivity: 65.3%; specificity: 78.3%) and 79° (AUC: 0.642; sensitivity: 36.7%; specificity: 92.6%). The ratio of the low attenuation area was also significantly higher in patients with a P-wave axis &gt;75° than in those with a P-wave axis ≤75°. However, the ratio of the airway wall area did not differ between the 2 groups. <b><i>Conclusions:</i></b> Patients with COPD with a vertical P-wave axis exhibited severe airflow limitation and emphysema, a worse health status, and more frequent exacerbation than patients without a vertical P-wave. Detection of the vertical P-wave axis by ECG is beneficial for the management of patients with COPD.
DOI: 10.6084/m9.figshare.17021921.v1
title: Supplementary Material for: Clinical Utility of the Electrocardiographic P-Wave Axis in Patients with Chronic Obstructive Pulmonary Disease

description: <b><i>Background:</i></b> The vertical P-wave axis on electrocardiography (ECG) is a useful criterion for screening patients with chronic obstructive pulmonary disease (COPD). This study aimed to investigate the clinical characteristics of patients with COPD with a vertical P-wave axis as they have not yet been elucidated. <b><i>Methods:</i></b> Keio University and its affiliated hospitals conducted an observational COPD cohort study over 3 years. We analyzed 201 patients using ECG and chest computed tomography. <b><i>Results:</i></b> The severity of airflow limitation was higher in patients with a P-wave axis &gt;75° than in those with a P-wave axis ≤75°. Patients with a P-wave axis &gt;75° exhibited significantly higher total COPD assessment test scores and increased St. George’s Respiratory Questionnaire total, activity, and impact scores than those with a P-wave axis ≤75°. The incidence of exacerbations over 1 and 3 years was significantly higher in patients with a P-wave axis &gt;75° than in those with a P-wave axis ≤75°. The optimal cutoff for the P-wave axis for a percentage of the predicted forced expiratory volume in 1 s &lt;50% and future exacerbations over 3 years was 70° (the areas under the curve [AUC]: 0.788; sensitivity: 65.3%; specificity: 78.3%) and 79° (AUC: 0.642; sensitivity: 36.7%; specificity: 92.6%). The ratio of the low attenuation area was also significantly higher in patients with a P-wave axis &gt;75° than in those with a P-wave axis ≤75°. However, the ratio of the airway wall area did not differ between the 2 groups. <b><i>Conclusions:</i></b> Patients with COPD with a vertical P-wave axis exhibited severe airflow limitation and emphysema, a worse health status, and more frequent exacerbation than patients without a vertical P-wave. Detection of the vertical P-wave axis by ECG is beneficial for the management of patients with COPD.
DOI: 10.6084/m9.figshare.17021870
title: Supplementary Material for: Association between Physical Activity, Sedentary Behaviors, Sleep, Diet, and Adiposity among Children and Adolescents in China

description: <b><i>Introduction:</i></b> Physical activity (PA), sedentary behaviors (SB), sleep, and diet are related to adiposity among children and adolescents. However, there may be interactions between PA, SB, sleep, and diet, and these lifestyle behaviors may work together to affect body weight. The purpose of this study was to explore the impact of multiple lifestyle behaviors of PA, SB, sleep, and diet on childhood adiposity (body mass index <i>z</i>-score and overweight/obesity), and to investigate the effect of meeting multiple guidelines on adiposity among children and adolescents in China. <b><i>Methods:</i></b> Cross-sectional results were based on 28,048 children aged 6–17 years from the China National Nutrition and Health Surveillance in 2010–2012. Information about PA, SB, and sleep was measured through interview-administered questionnaire. Dietary intake was assessed with food frequency questionnaire. The associations between multiple lifestyle behaviors and BMI <i>z</i>-score and overweight/obese were examined. <b><i>Results:</i></b> The prevalence of overweight/obesity in the participants was 19.2%. The average time of moderate-to-vigorous PA (MVPA), leisure SB, and sleep was 76.7 ± 45.5 min, 2.9 ± 1.4 h, and 8.5 ± 1.1 h per day, respectively. The China Dietary Guidelines Index for Youth (CDGI-Y) score was 62.6 ± 11.0. Sleep duration and diet score were negative associated with BMI <i>z</i>-score (both <i>p</i> &lt; 0.001). MVPA and SB time were positive associated with BMI <i>z</i>-score (<i>p</i> = 0.041, 0.004). Meeting the SB, sleep, and diet guidelines had a lower BMI <i>z</i>-score (all <i>p</i> &lt; 0.01) and lower odds of overweight/obesity (all <i>p</i> &lt; 0.05). There were significant interactions between PA and diet. Compared with meeting no guidelines, those who met multiple guidelines had a lower risk of overweight/obesity (all <i>p</i> &lt; 0.01). The more guidelines the participants met, the lower odds of overweight/obesity (<i>p</i> for trend &lt;0.001). <b><i>Conclusions:</i></b> PA, SB, sleep, and diet are important behaviors associated with adiposity among children and adolescents. Attaining adequate amounts of appropriate multiple behaviors provided an additional benefit. It is important for children to meet recommended behavioral guidelines or recommendations. Interventions that aim to improve awareness of and compliance with these guidelines are needed in future.
DOI: 10.5281/zenodo.5704168
title: Data for "Heuristic algorithms in Evolutionary Computations and modular organization of biological macromolecules: applications to in vitro evolution"

description: This publication contains data for the construction of the figures and tables for the paper "Heuristic algorithms in Evolutionary Computations and modular organization of biological macromolecules: applications to in vitro evolution" accepted to publication in PLOS ONE.
description: This work is supported by the Russian Science Foundation (grant 17-18-01536).
DOI: 10.5281/zenodo.5704167
title: Data for "Heuristic algorithms in Evolutionary Computations and modular organization of biological macromolecules: applications to in vitro evolution"

description: This publication contains data for the construction of the figures and tables for the paper "Heuristic algorithms in Evolutionary Computations and modular organization of biological macromolecules: applications to in vitro evolution" accepted to publication in PLOS ONE.
description: This work is supported by the Russian Science Foundation (grant 17-18-01536).
DOI: 10.25721/56wz-cd72
title: Le troupeau
DOI: 10.25721/zdz6-0f28
title: Passage d'un troupeau
DOI: 10.34740/kaggle/dsv/2818168
title: AutoXGB
DOI: 10.14457/tu.the.2020.540
title: ปัจจัยที่ส่งผลต่อความพึงพอใจในการใช้งานระบบ employee self service (ESS) ของบริษัท ท่าอากาศยานไทย จำกัด (มหาชน)

description: ปัจจุบันการพัฒนาระบบเทคโนโลยีสารสนเทศซึ่งเกี่ยวกับระบบการจัดการข้อมูลส่วนบุคคลมีความก้าวหน้าอย่างมาก บริษัท ท่าอากาศยานไทย จำกัด (มหาชน) ได้นำระบบ Employee Self Service หรือ ระบบ ESS ซึ่งเป็นระบบจัดการข้อมูลส่วนบุคคลเข้ามาใช้งานเพื่อเพิ่มประสิทธิภาพในกระบวนการการจัดการข้อมูลส่วนบุคคลให้ดียิ่งขึ้น ซึ่งข้อมูลดังกล่าวจะมีความถูกต้องแม่นยำและดำเนินการอยู่บนฐานข้อมูลเดียวกัน รวมถึงลดเวลาและความซ้ำซ้อนจากการดำเนินการ เช่น การยื่นใบลา การเบิกจ่ายค่าสวัสดิการ หรือการแก้ไขข้อมูลส่วนบุคคล เป็นต้น โดยพนักงานทุกคนจะใช้งานระบบ ESS อยู่บ่อยครั้ง เพื่อให้เกิดความพึงพอใจในการใข้งานที่มากที่สุด องค์กรจึงเห็นถึงความสำคัญในการพัฒนาประสิทธิภาพของระบบการบริหารจัดการเพื่อเพิ่มความพึงพอใจสูงที่สุดให้แก่พนักงานงานวิจัยชิ้นนี้จึงศึกษาถึงปัจจัยที่ส่งผลต่อความพึงพอใจในการใช้งานระบบ Employee Self Service (ESS) ของบริษัท ท่าอากาศยานไทย จำกัด (มหาชน) โดยนำเอาทฤษฎีความสำเร็จของระบบสารสนเทศ ทฤษฎีการยอมรับเทคโนโลยี ทฤษฎีเทคโนโลยี-องค์กร-สิ่งแวดล้อม รวมถึงปัจจัยด้านการอบรมและปัจจัยด้านการสนับสนุนของฝ่ายบริหารระดับสูงจากงานวิจัยในอดีตที่เกี่ยวข้อง เพื่อที่จะศึกษาว่าปัจจัยใดที่ส่งผลให้ผู้ใช้งานระบบ ESS เกิดความพึงพอใจในการใช้งาน โดยงานวิจัยชิ้นนี้เป็นงานวิจัยเชิงปริมาณ (Quantitative Research) ซึ่งผู้วิจัยใช้วิธีการเก็บข้อมูลจากการแจกแบบสอบถาม โดยมีกลุ่มตัวอย่างคือ พนักงานของ บริษัท ท่าอากาศยานไทย จำกัด (มหาชน) ที่เคยใช้งานระบบ ESS ในการจัดการข้อมูลส่วนบุคคลจำนวนทั้งสิ้น 262 คน ผลการวิจัยพบว่าปัจจัยด้านคุณภาพสารสนเทศ ปัจจัยด้านคุณภาพระบบ การรับรู้ความง่ายในการใช้งาน และการรับรู้ประโยชน์ในการใช้งาน ส่งผลให้เกิดความพึงพอใจของพนักงานผู้ใช้งานระบบ ESS นอกจากนี้ผลการวิจัยยังพบว่าปัจจัยด้านการอบรม ปัจจัยด้านการสนับสนุนของฝ่ายบริหารระดับสูง และปัจจัยด้านคุณภาพการบริการสามารถส่งผลให้เกิดการรับรู้ความง่ายในการใช้งาน และในขณะเดียวกันปัจจัยการสนับสนุนของฝ่ายบริหารระดับสูง ปัจจัยด้านคุณภาพสารสนเทศ และปัจจัยด้านคุณภาพระบบส่งผลให้เกิดการรับรู้ประโยชน์ในการใช้งาน
DOI: 10.25721/c61j-c122
title: Passage du troupeau de Monsieur Louis Rieucan
DOI: 10.25721/nyfb-a371
title: Arrivée du troupeau sur la place. Têtée des veaux
DOI: 10.5281/zenodo.5704172
title: Reproducibility Package: Automata-Driven Partial Order Reduction and Guided Search for LTL

description: Reproducibility package for the paper <strong>Automata-Driven Partial Order Reduction and Guided Search for LTL Model Checking</strong> accepted for VMCAI'22. Contains scripts, 64-bit Linux binaries, and the dataset used to run the experiments detailed in the paper, a source code snapshot used to compile those binaries, as well as scripts for processing the results into the tables seen in the paper. The file README.md contains details on running the various parts of the artifacts, assuming a Linux environment.
DOI: 10.5281/zenodo.5704171
title: Reproducibility Package: Automata-Driven Partial Order Reduction and Guided Search for LTL

description: Reproducibility package for the paper <strong>Automata-Driven Partial Order Reduction and Guided Search for LTL Model Checking</strong> accepted for VMCAI'22. Contains scripts, 64-bit Linux binaries, and the dataset used to run the experiments detailed in the paper, a source code snapshot used to compile those binaries, as well as scripts for processing the results into the tables seen in the paper. The file README.md contains details on running the various parts of the artifacts, assuming a Linux environment.
DOI: 10.18462/iir.pcm.2021.1948
title: Phase change dispersions for isothermal cooling applications.
DOI: 10.18462/iir.pcm.2021.1947
title: Thermal energy storage with PCM for refrigerated sea water system of fishing vessels.
DOI: 10.18462/iir.pcm.2021.1945
title: Active control of supercooling degree by amphoteric surfactants showing cationicity under voltage application.
DOI: 10.18462/iir.pcm.2021.1942
title: Study on beat transfer characteristics of pcm slurry of superhydrophobic gel particles adsorbing paraffin.
DOI: 10.18462/iir.pcm.2021.1939
title: Cold storage using phase change material in refrigerated display cabinets: experimental investigation.
DOI: 10.18462/iir.pcm.2021.1938
title: Experimental study of heat transfer of ice slurry based on MPG in laminar flows.
DOI: 10.18462/iir.pcm.2021.1937
title: New method of processing ice slurry for improved chilling of fresh foods.
DOI: 10.18462/iir.pcm.2021.1935
title: Numerical studies of the behaviour of isothermal and non-isothermal ice slurry inside the special plate heat exchanger.
DOI: 10.48372/04bffd1a-241f-4241-9853-15408ae90243
title: Macrozoobenthos data collected in the Lesina Lagoon, Apulia, Italy, in 2009.

description: The dataset contains abundance and body size data of the benthic macroinvertebrates community of the Lesina lagoon. Data refer to 21 taxa (15 species, 2 genus, 2 family, 2 subclass) and 9595 individuals.
DOI: 10.6084/m9.figshare.17021981.v1
title: y_test

description: 测试集中的铁浓度标签
DOI: 10.6084/m9.figshare.17021981
title: y_test

description: 测试集中的铁浓度标签
DOI: 10.18462/iir.pcm.2021.1934
title: Reviewing the solid-liquid phase transition enthalpies of popular salt hydrate PCM.
DOI: 10.6084/m9.figshare.17021978
title: x_test

description: spectra in the test set
DOI: 10.6084/m9.figshare.17021978.v1
title: x_test

description: spectra in the test set
DOI: 10.18462/iir.pcm.2021.1933
title: How to measure the melting enthalpy of semicongruently melting salt hydrate PCM.
DOI: 10.25721/vkk7-gt39
title: Départ du troupeau pour la montagne (Regambal-bas)
DOI: 10.18462/iir.pcm.2021.1930
title: Experimental evaluation of a heat pump-latent storage system for increasing renewable share of the residential stock.
DOI: 10.18462/iir.pcm.2021.1924
title: Effect of phase change material (PCM) on the temperature rise of a refrigerator: experiment and basic model.
DOI: 10.25721/p9xe-xb41
title: Sont descendus les garçons de la montagne
DOI: 10.5519/qd.37sxp6s1
title: Query on the Natural History Museum Data Portal (data.nhm.ac.uk) (1 records)
DOI: 10.5281/zenodo.5704369
title: msd-errors - Data for the LLZO figure

description: Data for the figure showing the diffusion and Arrhenius plots for a short simulation of LLZO. <br><br>Created using showyourwork from this GitHub repo.
DOI: 10.5281/zenodo.5704367
title: msd-errors - Data for AgCrSe2 figures

description: Data for the figures Results of the analysis of AgCrSe2 systems by kinisi at a series of temperatures.<br><br>Created using showyourwork from this GitHub repo.
DOI: 10.25721/8jbv-6995
title: La trotteuse
DOI: 10.25721/ysta-5d63
title: Le rossignol
DOI: 10.15468/92n8wj
title: Leptagrion jeromei (Odonata: Coenagrionidae) spec. nov. from Brazil, with notes on L. andromache Hagen in Selys, 1876

description: This dataset contains the digitized treatments in Plazi based on the original journal article Vilela, Diogo Silva, Junior, Manoel Daltro Nunes Garcia, Furieri, Karina S., Lencioni, Frederico A. A. (2021): Leptagrion jeromei (Odonata: Coenagrionidae) spec. nov. from Brazil, with notes on L. andromache Hagen in Selys, 1876. Zootaxa 5068 (2): 240-246, DOI: https://doi.org/10.11646/zootaxa.5068.2.4
DOI: 10.5281/zenodo.5704197
title: Cross Project Code Context Prediction for Software Development Tasks

description: The cross-project dataset of 3,469 code context models (Code Context Models.rar) and topological patterns (Pattern Bases.rar) from Platform, PDE, and ECF.
DOI: 10.5281/zenodo.5704368
title: msd-errors - Data for variance and covariance figure

description: Data for a figure that presents the variance and covariance for a true random walk. There is a comparison shown between the numerical result from 1024 unique random walks and the analysis, by kinisi, of the same 1024 random walks.<br><br>Created using showyourwork from this GitHub repo.
DOI: 10.5281/zenodo.5704406
title: msd-errors - Data for diffusion coefficient and offset figures

description: Data for a figure that shows the distributions of the mean and varance of the diffusion coefficient and offset that are found from the analysis of 1024 unique random walks using kinisi. This is performed for both a truely random walk and a temporally anti-correlated random walk.<br><br>Created using showyourwork from this GitHub repo.
DOI: 10.6084/m9.figshare.17022017
title: WMF.dat

description: WMF The coordinates of the Western marginal fault.
DOI: 10.6084/m9.figshare.17022017.v1
title: WMF.dat

description: WMF The coordinates of the Western marginal fault.
DOI: 10.6084/m9.figshare.17022035.v1
title: Data of the SDVS method

description: The data package including train_x, train_y, valid_x, valid_y, test_x and test_y
DOI: 10.6084/m9.figshare.17022035
title: Data of the SDVS method

description: The data package including train_x, train_y, valid_x, valid_y, test_x and test_y
DOI: 10.13012/b2idb-7636863_v1
title: Seedling traits in oak and mix stands

description: Data from an a field experiment at El Velo, Chiriqui, Republic of Panama. Data contain information about functional traits of seedlings growing in different treatments including type of forest, nitrogen addition and organic matter.
DOI: 10.25721/s97j-yy10
title: En passant par le bois
DOI: 10.5281/zenodo.5703268
title: Neglected very-long-chain hydrocarbons and the incorporation of body surface areas reveal novel perspectives for chemical profile analysis in insects

description: Most of what we know about insect cuticular hydrocarbons (CHCs) has been informed by analyses with gas-chromatography coupled with mass spectrometry (GC-MS). However, this analysis technique has its limit, particularly in detecting compounds in a chain length range beyond around C40. Here, we attempt to differentiate the range of CHCs detectable by GC-MS with the largely neglected very-long-chain CHC range up to C58 analyzed by silver-assisted laser desorption/ionization mass spectrometry (Ag-LDI-MS), in seven species of the order Blattodea. For all tested species we unveiled a considerable range of very-long-chain CHCs not detectable by traditional GC-MS technology. This strongly suggests that general studies on insect CHCs routinely miss compounds in that range, and we encourage future studies to implement technologies capable of detecting very-long-chain CHCs. Furthermore, we implement 3D scanned insect body surface areas when quantifying CHC amounts per GC-MS, as Ag-LDI-MS is less suited to quantify total CHC contents. Proportional CHC distributions differed considerably when adjusted for body surface areas, suggesting the importance of their consideration. Moreover, correlations between body surface areas and GC-MS assessed CHC amounts were not significant, further hinting the inaccessibility of whole CHC profile ranges by this technique, potentially by missing the clearly present very-long-chain CHCs.
DOI: 10.15468/4gss7s
title: Micoteca ARAN-fungi

description: Pendiente de cargar los datos del Endpoint.
DOI: 10.15468/k9mq2g
title: Ornitho.eus

description: Pendiente de cargar los datos del Endpoint.
DOI: 10.15468/wq8atk
title: Base de datos de plantas vasculares del País Vasco: ARAN-EH

description: Pendiente de cargar los datos del Endpoint.
DOI: 10.15468/vk8hx5
title: Fauna marina de la costa vasca

description: Pendiente de cargar los datos del Endpoint.
DOI: 10.15468/3tp6b2
title: Anillamiento SEO

description: Pendiente de cargar los datos del Endpoint.
DOI: 10.15468/qrcdh7
title: iNaturalist

description: Pendiente de cargar los datos del Endpoint.
DOI: 10.15468/cmm7ru
title: Herbario ARAN

description: Pendiente de cargar los datos del Endpoint.
DOI: 10.15468/fbq46w
title: Herbario VIT - Plantas Vasculares (Museo de Historia Natural de Álava)

description: Pendiente de cargar los datos del Endpoint.
DOI: 10.15468/p3kfpy
title: Herbario BIO

description: Pendiente de cargar los datos del Endpoint.
DOI: 10.6084/m9.figshare.14865118
title: Estimating cost-effectiveness of screening for colorectal cancer in Vietnam

description: <b>Background:</b>Presently, there are no national screening programs for cancer in Vietnam. This study aimed to analyze the cost-effectiveness of an annual colorectal cancer (CRC) screening program from the healthcare service provider’s perspective for the Vietnamese population. <b>Methods:</b>The economic model consisted of adecision tree and aMarkov model. Adecision tree was constructed for comparing two strategies, including ascreening group with aguaiac-based fecal occult blood test (<i>g</i>FOBT) and ano-screening group in general populations, aged 50 years and above. The Markov model projected outcomes over a25-year horizon. The cost-effectiveness outcome was the incremental cost-effectiveness ratio (ICER) represented by costs per quality-adjusted life-years (QALYs). <b>Results:</b>When compared with no screening, ICER was $1,388per QALY with an increased cost of $ 43.98 and again of 0.032 QALY (Willingness to pay $2,590). The uptake rate of gFOBT, cost of colonoscopy, and the total cost of screening contributed to the largest impact on the ICER. PSA showed that results were robust to variation in parameter estimates, with annual screening remaining cost-effective compared with no screening. <b>Conclusion:</b>Our screening strategy could be considered cost-effective compared to ano screening strategy. Our findings could be potentially used to develop aCRC national screening program.
DOI: 10.6084/m9.figshare.14865118.v1
title: Estimating cost-effectiveness of screening for colorectal cancer in Vietnam

description: <b>Background:</b>Presently, there are no national screening programs for cancer in Vietnam. This study aimed to analyze the cost-effectiveness of an annual colorectal cancer (CRC) screening program from the healthcare service provider’s perspective for the Vietnamese population. <b>Methods:</b>The economic model consisted of adecision tree and aMarkov model. Adecision tree was constructed for comparing two strategies, including ascreening group with aguaiac-based fecal occult blood test (<i>g</i>FOBT) and ano-screening group in general populations, aged 50 years and above. The Markov model projected outcomes over a25-year horizon. The cost-effectiveness outcome was the incremental cost-effectiveness ratio (ICER) represented by costs per quality-adjusted life-years (QALYs). <b>Results:</b>When compared with no screening, ICER was $1,388per QALY with an increased cost of $ 43.98 and again of 0.032 QALY (Willingness to pay $2,590). The uptake rate of gFOBT, cost of colonoscopy, and the total cost of screening contributed to the largest impact on the ICER. PSA showed that results were robust to variation in parameter estimates, with annual screening remaining cost-effective compared with no screening. <b>Conclusion:</b>Our screening strategy could be considered cost-effective compared to ano screening strategy. Our findings could be potentially used to develop aCRC national screening program.
DOI: 10.6084/m9.figshare.15051936.v1
title: The patent maze of COVID 19 vaccines

description: <b>Introduction</b>: NGOs and governments of some countries have demanded suspension of patents protection of COVID-19 vaccines and the underlying technology to enhance worldwide access. At the same time, companies actually developing and producing COVID-19 vaccines have to navigate the patent landscape and have to deal with 3rd party patents. <b>Areas covered</b>: This article discusses these different aspects regarding patent protection of COVID-19 vaccines. Patent searches have been carried out in Espacenet and the ORBIT database. Different search strings were used by the author, based on his own background knowledge. <b>Expert opinion</b>: SARS-CoV 2 was for the first time fully described on 10 January 2020, so it is so far not possible to determine if, and by whom, patent applications were filed for respective vaccines. On that background, allegations that patents would be responsible for insufficient access to the vaccine in particular in developing countries are baseless. Even the key players are facing contraints caused by third-party patents, and legal disputes are already ongoing. Anyway, the bigger obstacle for worldwide equitable vaccine distribution seems to reside in know how transfer and production capacities, as ramping up production requires considerable efforts.