cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.8195120.v1
title: Professional Expectations of Future Doctors: Analysis of the Quadriennium 2014-2017

description: ABSTRACT The objective of this work is to describe the expectations of medical students regarding their professional career. In order to do this, a cross-sectional descriptive and analytical study was conducted, from January 2014 to December 2017, with 116 senior students of the class of 2014, 116 of 2015, 91 of 2016 and 110 of 2017, with a total of 431 individuals. A survey was applied to obtain information about their age, gender, graduation year, professional expectations for the 10 years to follow, intended specialty, level of care at which they want to work, intended income, the number of jobs they think they will need to work in to reach that level of income and the number of jobs they expect to have. The study showed that there are more male students (58%) than female, and the average age is 26.4 ± 3.91 years old. General Medicine was the most sought specialty by the graduate students, except for those of the year 2016, when the predominant specialty was Pediatrics. Concerning the professional goals for the 10 years after graduation, teaching was an objective of approximately half of them, ranging between 46% and 59%, while almost all of them demonstrated a wish to perform assistance work (direct patient care). No predominance was found when comparing the expectation of working in a hospital or in private clinics, nor between the private and public sector. Concerning the wish to work at different health care levels, the senior students from the classes of 2014 and 2016 expressed their wish to work predominantly at care level 3 (40.5 ± 29.3% and 41.1 ± 29.7%, respectively). Concerning the intended income, the most popular range was above 10 minimum monthly salaries. Most students stated they believe that at least three jobs would be necessary to reach this salary level, but they also expressed the wish of having only two jobs. We conclude that the so-called basic areas, such as General Medicine, General Surgery and Pediatrics are the most coveted by the senior students. However, this is probably due not only to a desire to follow these specialties, but also because they represent a prerequisite to access other specialties. In general, the graduates intend to work with direct care and have high salary expectations, which is only achieved by having multiple jobs. They have little interest in working at care level one. This reality could be discussed in academic circles, in order to offer realistic information to students about the job market and medical career, minimizing future frustrations during their professional practice.
DOI: 10.6084/m9.figshare.8195123
title: Medical Student’s Knowledge of Ophthalmology

description: ABSTRACT This research was based on a descriptive study, aimed at evaluating medical students’ knowledge about Ophthalmology. A questionnaire composed of 20 questions was applied through the Survey Monkey app, which were answered by 1st- to 6th- year medical students. Based on the data collected, it was found that there is an increase in the level of knowledge about Ophthalmology according to the- year of study (5th and 6th year students have greater ownership of the subject) and also students who opted for Ophthalmology as a future specialization. Furthermore, another important finding was that although the students are aware of important ophthalmologic pathologies, they are not fully familiar with the management of emergencies and ophthalmologic procedures as general practitioners in the Emergency Room.
DOI: 10.6084/m9.figshare.8195126.v1
title: On mechanical vibration analysis of a multi degree of freedom system based on arduino and MEMS accelerometers

description: This paper is aimed at undergraduate students of physics, engineering and mathematics, where a methodology for mechanical vibration analysis of a multi degree of freedom (DOF) excited by an harmonic force in the time and frequency domain is presented. The Arduino microcontroller is used as an acquisition system and low-cost MEMS accelerometers for the instrumentation of the system. System of multi DOF are studied in a great number of problems in mechanical sciences, however its experimental study is not always present in the courses due to the high costs and complexity. These problems are overpassed with the study proposed in this work. Besides, the application presented has an interface with several disciplines in undergraduation and graduation level. The method proposed can be easy implemented and the results obtained had good precision and are in agreement with the literature.
DOI: 10.6084/m9.figshare.8195129
title: Autoimmune Progesterone Dermatitis: A Case Report

description: Abstract  Introduction  Autoimmune progesterone dermatitis (APD) is a rare autoimmune dermatosis characterized by recurrent cutaneous and mucosal lesions during the luteal phase of the menstrual cycle that disappear some days after the menses.  Case Report A 34-year-old primipara woman with no significant past medical history and no prior exogenous hormone use, who presented with cyclic skin eruptions starting 1 year after the delivery. The lesions occurred 6 days before the menses and disappeared in between 1 and 2 days after the menstruation ceased. The patient was diagnosed after a positive response to an intradermal test with progesterone and was successfully treated with combined oral contraceptives. The skin eruptions have not returned since the initiation of this therapy.  Conclusion  Dermatologists, gynecologists, and obstetricians should be aware of this rare entity. Furthermore, if this condition is suspected, a thorough history taking on the menstrual cycle and results of the intradermal progesterone test are mandatory.
DOI: 10.6084/m9.figshare.8195132
title: Simultaneous Determination of 2,3,7,8-TCDD and 2,3,7,8-TCDF in Water Samples by LLE-LTP and HPLC-DAD

description: Polychlorinated dibenzo-p-dioxins and dibenzofurans are persistent organic pollutants which can mainly be found in the environment in water. These compounds are highly toxic and therefore developing new extraction methodologies that are simpler and cost less is highly desirable. This study aimed to optimize and validate the liquid-liquid extraction with low-temperature partition methodology of 2,3,7,8-tetrachlorodibenzo-p-dioxin and 2,3,7,8-tetrachlorodibenzofuran in water samples. The optimum extraction conditions were 8.0 mL of the acetonitrile and 4.0 mL of the water, homogenized in a vortex for 1 min and then maintained at -20 ºC for 1 h. The analytes recovery percentage was close to 100% and relative standard deviation was less than 7%. The methodology was precise, accurate, linear at 2.4-5.4 µg L-1, and selective, with a quantification limit of 2.4 µg L-1. The optimized methodology was applied in ten real samples and the results showed that these analytes were not detected.
DOI: 10.6084/m9.figshare.8195141
title: Effects of gene therapy on cardiovascular symptoms of lysosomal storage diseases

description: Abstract Lysosomal storage diseases (LSDs) are inherited conditions caused by impaired lysosomal function and consequent substrate storage, leading to a range of clinical manifestations, including cardiovascular disease. This may lead to significant symptoms and even cardiac failure, which is an important cause of death among patients. Currently available treatments do not completely correct cardiac involvement in the LSDs. Gene therapy has been tested as a therapeutic alternative with promising results for the heart disease. In this review, we present the results of different approaches of gene therapy for LSDs, mainly in animal models, and its effects in the heart, focusing on protocols with cardiac functional analysis.
DOI: 10.6084/m9.figshare.8195141.v1
title: Effects of gene therapy on cardiovascular symptoms of lysosomal storage diseases

description: Abstract Lysosomal storage diseases (LSDs) are inherited conditions caused by impaired lysosomal function and consequent substrate storage, leading to a range of clinical manifestations, including cardiovascular disease. This may lead to significant symptoms and even cardiac failure, which is an important cause of death among patients. Currently available treatments do not completely correct cardiac involvement in the LSDs. Gene therapy has been tested as a therapeutic alternative with promising results for the heart disease. In this review, we present the results of different approaches of gene therapy for LSDs, mainly in animal models, and its effects in the heart, focusing on protocols with cardiac functional analysis.
DOI: 10.6084/m9.figshare.8195144.v1
title: Can quadrivalent human papillomavirus prophylactic vaccine be an effective alternative for the therapeutic management of genital warts? an exploratory study

description: ABSTRACT  Objective: To evaluate the treatment effect of genital warts, we investigated the quadrivalent HPV vaccine injection compared with surgical excision.  Materials and Methods: This prospective study included 26 patients (M:F = 24:2) who received HPV vaccine or surgical excision. After explanation of surgical excision or HPV vaccine, 16 patients underwent surgical excision and the others received HPV vaccine injections. Based on gross findings of genital warts, treatment outcomes were classified as complete response (no wart), partial response, and failed treatment.  Results: Among enrolled patients, 42% (11 / 26) patients had recurrent genital warts. In vaccination group, complete response rates of genital wart were 60% following 3 times HPV vaccine. Partial response patients wanted to excise the genital lesions before the 3 times injection, because they worried about sexual transmission of disease to their sexual partners. One patient underwent surgical excision after 3 times injection. Excision sites included suprapubic lesions, but other sites including mid-urethra and glans showed complete response after injection. At a mean follow-up period of 8.42 ± 3.27 months, 10 patients (100%) who received HPV vaccine did not show recurrence.  Conclusion: The response rates after HPV vaccine injection were 90% (complete and partial). Our results suggested that HPV vaccines could be effective in management of genital warts.
DOI: 10.6084/m9.figshare.8195147.v1
title: Perspectives and Applications of Natural Products as Civilian Defense Devices

description: Civilian defense devices are physical and chemical artefacts used to incapacitate an aggressor without causing death or injury. As city violence increases, safety feelings became worst and a growing commercial demand for these materials supply faces technologically challenges not only to riot control but also to self-protection. Controversies on the use of these devices have been discussed, especially on their toxicity when synthetic chemical agents are used. Natural metabolites are a less explored alternative to meet this demand. They have the capacity to generate a temporary disabling effect due to their pungency. Those metabolites, which include capsaicinoids, gingerols and piperine, can be used as deterrent agents in civilian defense devices due to their low toxicity to humans. Although they are a viable alternative, there are few studies focused on their quality control, efficiency and toxicity. This review aimed to present relevant aspects about the development and use of natural products as deterrent agents in self-defense devices against aggressors and animals, and as non-lethal weapons for riot control in order to help the scientific development of this type of bioproduct.
DOI: 10.6084/m9.figshare.8195150.v1
title: Initial experience of video endoscopic inguinal Lymphadenectomy in a center located at northeast brazilian region

description: ABSTRACT  Introduction: Video endoscopic inguinal lymphadenectomy – VEIL – has emerged as an alternative to reduce post-surgical complications (PSC) in patients with penile cancer submitted to inguinal lymphadenectomy (IL). In some series, these PSC are observed in more than 50% of patients. The objectives of the present study are to describe the initial experience of VEIL in a Hospital in Teresina, PI, Brazil, and to analyze PSC incidence.  Material and Methods: Retrospective descriptive study of patients submitted to VEIL from March 2014 to November 2015. Data were collected regarding surgical time, bleeding, complications, lymph node number, conversion, global complications, drainage time, cellulitis, lymphocele, cutaneous necrosis, miocutaneous necrosis and hospitalization time.  Results: 20 lower limbs of 11 patients were operated. Mean age was 51.4 (24-72) years. Mean surgical time was 85 (60-120) minutes. No patient showed intrasurgical complications, bleeding &gt; 50 mL or conversion. Three surgeries evolved with lower limb edema, 2 with lymphoceles and one patient had cutaneous necrosis and another bulging of surgical wound. Mean time of hospitalization was 4 (2-11) days. A mean of 5.8 (1-12) lymph nodes were dissected in each surgery.  Conclusion: VEIL is a safe and easy technique with lower incidence of PSC that can be reproduced in small centers.
DOI: 10.6084/m9.figshare.8195156
title: Ferulate Anion Intercalated into Zn/Al Layered Double Hydroxide: A Promising Intercalation Compound for Inhibition of Leishmania (L.) amazonensis

description: Ferulic acid (FERH) is known to exert leishmanicidal action against Leishmania (Leishmania) amazonensis. In this study, the ferulate anion (FER–) was intercalated into a layered double hydroxide (LDH) for FER– delivery during an antileishmania in vitro test. The LDH-FER– intercalation compound was prepared by coprecipitation and was characterized by X-ray powder diffraction, thermogravimetry, UV-Vis, infrared, and Raman spectroscopy analyses. Leishmania (L.) amazonensisin vitro assays were conducted to assess the LDH-FER– potential. LDH-FER– was found to promote a dose-dependent reduction of L. (L.) amazonensis amastigotes (intracellular form, half maximal inhibitory concentration (IC50) = 1.78 µg mL-1) without exerting a deleterious effect on the host macrophages (medium cytotoxic concentration (CC50) = 212.61 µg mL-1 and selectivity index = 119.4). LDH-FER– was found to be an effective inhibitor of the amastigote form of L. (L.) amazonensis, suggesting that LDH-FER– was able to deliver FER– inside the parasitophorous vacuoles where the pH is more acidic.
DOI: 10.6084/m9.figshare.8195156.v1
title: Ferulate Anion Intercalated into Zn/Al Layered Double Hydroxide: A Promising Intercalation Compound for Inhibition of Leishmania (L.) amazonensis

description: Ferulic acid (FERH) is known to exert leishmanicidal action against Leishmania (Leishmania) amazonensis. In this study, the ferulate anion (FER–) was intercalated into a layered double hydroxide (LDH) for FER– delivery during an antileishmania in vitro test. The LDH-FER– intercalation compound was prepared by coprecipitation and was characterized by X-ray powder diffraction, thermogravimetry, UV-Vis, infrared, and Raman spectroscopy analyses. Leishmania (L.) amazonensisin vitro assays were conducted to assess the LDH-FER– potential. LDH-FER– was found to promote a dose-dependent reduction of L. (L.) amazonensis amastigotes (intracellular form, half maximal inhibitory concentration (IC50) = 1.78 µg mL-1) without exerting a deleterious effect on the host macrophages (medium cytotoxic concentration (CC50) = 212.61 µg mL-1 and selectivity index = 119.4). LDH-FER– was found to be an effective inhibitor of the amastigote form of L. (L.) amazonensis, suggesting that LDH-FER– was able to deliver FER– inside the parasitophorous vacuoles where the pH is more acidic.
DOI: 10.6084/m9.figshare.8195159
title: Primary renal angiosarcoma with extensive hemorrhage: CT and MRI findings

description: ABSTRACT Primary angiosarcomas of the kidney are very rare, but highly aggressive tumors showing poor prognosis. Patients frequently complain of flank pain, hematuria, or a palpable mass. We present a case of primary renal angiosarcoma occurring in a 61-year-old man. CT images depicted a huge exophytic mass (16 cm in diameter) in the right kidney, exhibiting extensive hemorrhage. The mass showed centripetal peripheral nodular enhancement on dynamic contrast-enhanced images. Furthermore, MR imaging revealed a tangled mesh of tumor vessels in the periphery of the mass. We suggest its inclusion in the differential diagnosis of cases of hemorrhagic renal tumors with prominent vasculature.
DOI: 10.6084/m9.figshare.8195168
title: Temporal changes in biological traits of diatom communities in response to an oil spill in a subtropical river

description: Abstract: Diatom growth strategies, which are used as a proxy to analyze disturbances and environmental impacts, can also provide reliable information about environmental gradients. In this study, we used diatom communities and biological traits to assess the structure of epilithic diatoms after an oil spill in a large tributary of the Iguaçu River (Paraná, Brazil). Epilithon and water samples were taken on July 12th, 2004, and after an unexpected oil spill, on the following days: 09/19, 10/03, and 10/13/2004. We observed that the spill caused a distinct shift in both diatom composition and guild group. Diversity decreased and pollution-tolerant diatoms of the motile group became dominant in response to the elevated nutrient levels and reduced light. Tube-forming diatoms, which are strong competitors for light, dominated the epilithon 24 days after the oil spill. Both diatom guilds and growth forms were successfully used to predict the environmental conditions. While diatom guilds responded to disturbances along a temporal gradient, changes inside the guilds were the main factor for understanding the environmental gradient.
DOI: 10.6084/m9.figshare.8195168.v1
title: Temporal changes in biological traits of diatom communities in response to an oil spill in a subtropical river

description: Abstract: Diatom growth strategies, which are used as a proxy to analyze disturbances and environmental impacts, can also provide reliable information about environmental gradients. In this study, we used diatom communities and biological traits to assess the structure of epilithic diatoms after an oil spill in a large tributary of the Iguaçu River (Paraná, Brazil). Epilithon and water samples were taken on July 12th, 2004, and after an unexpected oil spill, on the following days: 09/19, 10/03, and 10/13/2004. We observed that the spill caused a distinct shift in both diatom composition and guild group. Diversity decreased and pollution-tolerant diatoms of the motile group became dominant in response to the elevated nutrient levels and reduced light. Tube-forming diatoms, which are strong competitors for light, dominated the epilithon 24 days after the oil spill. Both diatom guilds and growth forms were successfully used to predict the environmental conditions. While diatom guilds responded to disturbances along a temporal gradient, changes inside the guilds were the main factor for understanding the environmental gradient.
DOI: 10.6084/m9.figshare.8195171
title: Can Neutrophil-to-Lymphocyte ratio predict the response to BCG in high-risk non muscle invasive bladder cancer?

description: ABSTRACT  Objectives: To evaluate the neutrophil-to-lymphocyte ratio (NLR) as a prognostic factor for response of high risk non muscle invasive bladder cancer (HRNMIBC) treated with BCG therapy.  Materials and Methods: Between March 2010 and February 2014 in a tertiary center 100 consecutive patients with newly diagnosed HRNMIBC were retrospectively analyzed. Patients were divided according to NLR value: 46 patients with NLR value less than 3 (NLR &lt; 3 group), and 54 patients with NLR value more than 3 (NLR ≥ 3 group). At the end of follow-up 52 patients were high grade disease free (BCG-responder group) and 48 patients underwent radical cystectomy for high grade recurrence or progression to muscle invasive disease (BCG non-responder group). The average follow-up was 60 months. Intervention: analysis and correlation of preoperative NLR value with response to BCG in terms of recurrence and progression.  Results: The optimal cut-off for NLR was ≥ 3 according to the receiver operating characteristics analysis (AUC 0.760, 95% CI, 0.669-0.850). Mean NLR value was 3.65 ± 1.16 in BCG non-responder group and 2.61 ± 0.77 in BCG responder group (p = 0.01). NLR correlated with recurrence (r = 0.55, p = 0.01) and progression risk scores (r = 0.49, p = 0.01). In multivariate analysis, NLR (p = 0.02) and EORTC recurrence risk groups (p = 0.01) were associated to the primary endpoint. The log-rank test showed statistically significant difference between NLR &lt; 3 and NLR ≥ 3 curves (p &lt; 0.05).  Conclusions: NLR value preoperatively evaluated could be a useful tool to predict BCG response of HRNMIBC. These results could lead to the development of prospective studies to assess the real prognostic value of NLR in HRNMIBC.
DOI: 10.6084/m9.figshare.8195174
title: Exploring Obstetrical Interventions and Stratified Cesarean Section Rates Using the Robson Classification in Tertiary Care Hospitals in the United Arab Emirates

description: Abstract  Objective  The objective of the present study was to explore obstetric management in relation to clinical, maternal and child health outcomes by using the Robson classification system.  Methods  Data was collected from obstetrics registries in tertiary care hospitals in Dubai, United Arab Emirates (UAE).  Results  The analysis of &gt; 5,400 deliveries (60% of all the deliveries in 2016) in major maternity hospitals in Dubai showed that groups 5, 8 and 9 of Robson’s classification were the largest contributors to the overall cesarean section (CS) rate and accounted for 30% of the total CS rate. The results indicate that labor was spontaneous in 2,221 (45%) of the women and was augmented or induced in almost 1,634 cases (33%). The birth indication rate was of 64% for normal vaginal delivery, of 24% for emergency CS, and of 9% for elective CS.The rate of vaginal birth after cesarean was 261(6%), the rate of external cephalic version was 28 (0.7%), and the rate of induction was 1,168 (21.4%). The prevalence of the overall Cesarean section was 33%; with majority (53.5%) of it being repeated Cesarean section.  Conclusion  The CS rate in the United Arab Emirates (UAE) is higher than the global average rate and than the average rate in Asia, which highlights the need for more education of pregnant women and of their physicians in order to promote vaginal birth. A proper planning is needed to reduce the number of CSs in nulliparous women in order to prevent repeated CSs in the future. Monitoring both CS rates and outcomes is essential to ensure that policies, practices, and actions for the optimization of the utilization of CS lead to improved maternal and infant outcomes.