cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.11609169
title: Cytotoxic Activity of Synthetic Chiral Amino Acid Derivatives

description: Cancer is a chronic degenerative disease considered one of the most important causes of death worldwide. In this context, a series of dual-protected amino acid derivatives was synthesized and evaluated as potential novel anticancer agents. The 40 derivatives were prepared in up to three reaction steps. The cytotoxic activities were screened in vitro against a panel of tumor and non-tumor cells using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Among the synthesized derivatives, three of them showed promising activity against cancer cells with half-maximal inhibitory concentration (IC50) ranging between 1.7-6.1 µM. The most promising derivative, bearing both a lipophilic N-alkyl diamine moiety and a protected amino acid scaffold showed a selectivity index of 3.4 towards tumor cells. The N-alkyl diamine moiety seems to play a crucial role in the enhancement of the anticancer activity. On the other hand, the incorporation of an amino acid scaffold resulted in increase in the selectivity towards cancer cell lines.
DOI: 10.6084/m9.figshare.11609169.v1
title: Cytotoxic Activity of Synthetic Chiral Amino Acid Derivatives

description: Cancer is a chronic degenerative disease considered one of the most important causes of death worldwide. In this context, a series of dual-protected amino acid derivatives was synthesized and evaluated as potential novel anticancer agents. The 40 derivatives were prepared in up to three reaction steps. The cytotoxic activities were screened in vitro against a panel of tumor and non-tumor cells using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Among the synthesized derivatives, three of them showed promising activity against cancer cells with half-maximal inhibitory concentration (IC50) ranging between 1.7-6.1 µM. The most promising derivative, bearing both a lipophilic N-alkyl diamine moiety and a protected amino acid scaffold showed a selectivity index of 3.4 towards tumor cells. The N-alkyl diamine moiety seems to play a crucial role in the enhancement of the anticancer activity. On the other hand, the incorporation of an amino acid scaffold resulted in increase in the selectivity towards cancer cell lines.
DOI: 10.6084/m9.figshare.11609163
title: Breastfeeding rate and speech-language therapy in the Kangaroo Method

description: ABSTRACT Purpose: to verify the hospital discharge rate in breastfeeding and speech-language practice during implementation of the kangaroo method in a tertiary-level teaching hospital. Methods: a retrospective and documentary study, whose data were collected from electronic medical records of all preterm and/or low birth weight newborns, born at or admitted to a teaching hospital, from August 2016 to August 2017, and who had received care by the speech-language team. Data were collected regarding sample characterization (gender, Apgar, gestational age, birth weight, and orotracheal intubation time); speech-language therapy time; description of the procedures used, such as weight to start breastfeeding, empty breast technique, translactation, and feeding method at the time of speech-language therapy and hospital discharge. Appropriate statistical tests were applied, adopting a significance level lower than 0.05%. Results: there was a higher rate of breastfeeding in moderately preterm infants, born in a gestational age of 30 to 34 weeks, and in low birth weight newborns. Conclusion: breastfeeding was the prevalent feeding method for newborns. The results show that the speech-language stimulation of newborns was adapted from the conventional model to that proposed by the Kangaroo Method, corroborating with humanized care guidelines.
DOI: 10.6084/m9.figshare.11609160
title: Investigating Surface Properties and Lithium Diffusion in Brookite-TiO2

description: Surfaces properties of TiO2 in the brookite phase and the lithium diffusion are studied using density functional theory (DFT) and interatomic potential simulations. Simulations predict that the brookite surfaces have a higher intrinsic Lewis acidity compared to the other polymorphs due to the presence of four coordinated Ti atoms on the surface in contrast to the most stable surfaces of anatase and rutile which have five coordinated Ti surface atoms. The surface reactivity of the brookite is then expected to be higher for catalysis. The (210) surface is the most stable calculated surface and some experimental morphologies have been revisited. Regarding Li intercalation, the migration occurs along the c-direction and open channel surfaces are desired, therefore particles exposing the (001) surface. Those differences on chemical/physical properties highlight the importance to control the nanoparticle shapes for a given application.
DOI: 10.6084/m9.figshare.11609157
title: Louis de Broglie's wave-particle duality: from textbooks’ blackboxes to a chain of reference presentation

description: Abstract We discuss the proposition of wave-particle duality made by Louis de Broglie in the period of 1922-1924 as well as the narratives of undergraduate Physics textbooks that introduce this topic. After a brief discussion on the nature of scientific reality, we point out the main theories, assumptions and techniques adopted by de Broglie to achieve the relation between momentum and wavelength. We use these elements as analytical categories, observing which of them are still present in four popular undergraduate introductory textbooks. Our results show that none of the textbooks used de Broglie's original strategy (mathematical derivation), treating his ideas as postulates. Moreover, we show that only few elements of de Broglie's original presentation are still commented by textbooks, which treat de Broglie's ideas as purely speculative, reinforcing the “genius myth”. In the sequence, we propose a didactic alternative, which we call a “chain of reference presentation”. In this strategy, we highlight that all scientific knowledge is supported by previous theories and it works as the ground of future scientific improvements. With this perspective, we perform a didactic derivation of de Broglie's momentum-wavelength relation (based on the original papers and on the specialized literature) and we introduce empirical and theoretical works that may be studied from it.
DOI: 10.6084/m9.figshare.11609160.v1
title: Investigating Surface Properties and Lithium Diffusion in Brookite-TiO2

description: Surfaces properties of TiO2 in the brookite phase and the lithium diffusion are studied using density functional theory (DFT) and interatomic potential simulations. Simulations predict that the brookite surfaces have a higher intrinsic Lewis acidity compared to the other polymorphs due to the presence of four coordinated Ti atoms on the surface in contrast to the most stable surfaces of anatase and rutile which have five coordinated Ti surface atoms. The surface reactivity of the brookite is then expected to be higher for catalysis. The (210) surface is the most stable calculated surface and some experimental morphologies have been revisited. Regarding Li intercalation, the migration occurs along the c-direction and open channel surfaces are desired, therefore particles exposing the (001) surface. Those differences on chemical/physical properties highlight the importance to control the nanoparticle shapes for a given application.
DOI: 10.6084/m9.figshare.11609163.v1
title: Breastfeeding rate and speech-language therapy in the Kangaroo Method

description: ABSTRACT Purpose: to verify the hospital discharge rate in breastfeeding and speech-language practice during implementation of the kangaroo method in a tertiary-level teaching hospital. Methods: a retrospective and documentary study, whose data were collected from electronic medical records of all preterm and/or low birth weight newborns, born at or admitted to a teaching hospital, from August 2016 to August 2017, and who had received care by the speech-language team. Data were collected regarding sample characterization (gender, Apgar, gestational age, birth weight, and orotracheal intubation time); speech-language therapy time; description of the procedures used, such as weight to start breastfeeding, empty breast technique, translactation, and feeding method at the time of speech-language therapy and hospital discharge. Appropriate statistical tests were applied, adopting a significance level lower than 0.05%. Results: there was a higher rate of breastfeeding in moderately preterm infants, born in a gestational age of 30 to 34 weeks, and in low birth weight newborns. Conclusion: breastfeeding was the prevalent feeding method for newborns. The results show that the speech-language stimulation of newborns was adapted from the conventional model to that proposed by the Kangaroo Method, corroborating with humanized care guidelines.
DOI: 10.6084/m9.figshare.11609154
title: Knowledge about medical ethics and conflict resolution during undergraduate courses

description: Abstract This descriptive cross–sectional study aimed to evaluate the medical student’s perception of the importance of medical ethics being taught and to measure their knowledge about the subject in a public university in the Northeast of Brazil. Through a questionnaire, applied to 230 undergraduates, it was possible to evaluate deficits caused by the absence of formal medical ethics education and to discuss the need for diversified approaches to the subject during graduation. Results show a higher rate of correct answers among undergraduates who attended at least one discipline on medical ethics; whereas they indicated an unsatisfactory rate of success in both groups. One third of the undergraduates who did not have contact with the subject revealed that they did not feel put at a disadvantaged by this gap, and 25.6% of the sample did not value the importance of the subject in comparison to other undergraduate subjects. Therefore, it is necessary to review medical education strategies to ensure better professionals in the future.
DOI: 10.6084/m9.figshare.11609154.v1
title: Knowledge about medical ethics and conflict resolution during undergraduate courses

description: Abstract This descriptive cross–sectional study aimed to evaluate the medical student’s perception of the importance of medical ethics being taught and to measure their knowledge about the subject in a public university in the Northeast of Brazil. Through a questionnaire, applied to 230 undergraduates, it was possible to evaluate deficits caused by the absence of formal medical ethics education and to discuss the need for diversified approaches to the subject during graduation. Results show a higher rate of correct answers among undergraduates who attended at least one discipline on medical ethics; whereas they indicated an unsatisfactory rate of success in both groups. One third of the undergraduates who did not have contact with the subject revealed that they did not feel put at a disadvantaged by this gap, and 25.6% of the sample did not value the importance of the subject in comparison to other undergraduate subjects. Therefore, it is necessary to review medical education strategies to ensure better professionals in the future.
DOI: 10.6084/m9.figshare.11609157.v1
title: Louis de Broglie's wave-particle duality: from textbooks’ blackboxes to a chain of reference presentation

description: Abstract We discuss the proposition of wave-particle duality made by Louis de Broglie in the period of 1922-1924 as well as the narratives of undergraduate Physics textbooks that introduce this topic. After a brief discussion on the nature of scientific reality, we point out the main theories, assumptions and techniques adopted by de Broglie to achieve the relation between momentum and wavelength. We use these elements as analytical categories, observing which of them are still present in four popular undergraduate introductory textbooks. Our results show that none of the textbooks used de Broglie's original strategy (mathematical derivation), treating his ideas as postulates. Moreover, we show that only few elements of de Broglie's original presentation are still commented by textbooks, which treat de Broglie's ideas as purely speculative, reinforcing the “genius myth”. In the sequence, we propose a didactic alternative, which we call a “chain of reference presentation”. In this strategy, we highlight that all scientific knowledge is supported by previous theories and it works as the ground of future scientific improvements. With this perspective, we perform a didactic derivation of de Broglie's momentum-wavelength relation (based on the original papers and on the specialized literature) and we introduce empirical and theoretical works that may be studied from it.
DOI: 10.6084/m9.figshare.11609148
title: Social Accountability of Medical Schools and Social Representations of Medical Students in the Context of the More Doctors Program

description: ABSTRACT Several debates, in the national and international context, have suggested the need for changes in medical education, so that it is in line with the organization of health systems. From this perspective, it is proposed that schools be guided by social accountability, which consists of ordering teaching, research and activities in service to meet health needs with a focus on areas that are difficult to reach. A more recent reference in medical education at the national level was the More Doctors Program, which provided for a new regulatory framework for medical education. It is evaluated that the modifications introduced by the Program can influence the elaboration of new social representations of medical students. Through the theory of social representations, a qualitative study was carried out to analyze the perception about the social accountability of the medical schools of 149 medical students, of the seventh semester of four courses of Federal Higher Education Institutions in the Northeast Region. Two of the courses are in the interior and were created by virtue of the More Doctors Program and another two correspond to courses in the state capital existing for more than 60 years. From the curriculum analysis of each course, they were termed “traditional” or “new”. In the results, it was observed that the students of the different courses resemble each other in terms of admission by quotas, but students of “new” courses have a greater entrance under affirmative action policies, including regional access criteria. Both groups of students have emphasized the term “duty” as a priority, which may refer to a more individual scope of the notion of accountability. The terms “citizenship” and “ethics” were also highlighted in both groups. Only for students in “new” schools were terms such as “commitment”, “justice” and “SUS” cited. This insight suggests a broader notion of social accountability in school students created under the More Doctors Program, despite insufficient national literature on this topic. The conclusion emphasizes the importance of the Program in the implantation of medical schools in regions that did not previously have this training. It also reinforces the relevance of the dedication of the teachers who implemented the courses in the interior of the Northeast, demonstrating the need to deepen in the themes that involve teacher development. It is suggested that there is a need to broaden the analysis of experiences such as these, so that they can be explored with the radicalism necessary to strengthen the Unified Health System.
DOI: 10.6084/m9.figshare.11609151
title: Model and determinants of state-local governments’ relations in Nigeria

description: Abstract Nigeria struggles to establish and sustain cooperative, interdependent state-local intergovernmental relations (IGR) by providing for the powers and rights of local governments in the federal constitution. Despite the provisions, the practice of state-local IGR has remained inclusive, hierarchical, dependent and competitive. This paper investigates the extent to which constitutional provisions determine state-local relations as against the macrostructure of intergovernmental relations between the federal government and states. The authors argue that it is difficult to expect a cooperative, interdependent, state-local IGR through constitutional provisions of the powers and rights of local governments, if the federal-state relations, which should be the determining framework of IGR is inclusive, hierarchical and dependent. The paper suggests that the lower forms of IGR in a federation (e.g. the state-local IGR), largely depend on the super-structure, which is that between the federal government and the lower tiers. The implication is that the level of autonomy enjoyed by local governments largely depends on the level of autonomy the states themselves enjoy.
DOI: 10.6084/m9.figshare.11609151.v1
title: Model and determinants of state-local governments’ relations in Nigeria

description: Abstract Nigeria struggles to establish and sustain cooperative, interdependent state-local intergovernmental relations (IGR) by providing for the powers and rights of local governments in the federal constitution. Despite the provisions, the practice of state-local IGR has remained inclusive, hierarchical, dependent and competitive. This paper investigates the extent to which constitutional provisions determine state-local relations as against the macrostructure of intergovernmental relations between the federal government and states. The authors argue that it is difficult to expect a cooperative, interdependent, state-local IGR through constitutional provisions of the powers and rights of local governments, if the federal-state relations, which should be the determining framework of IGR is inclusive, hierarchical and dependent. The paper suggests that the lower forms of IGR in a federation (e.g. the state-local IGR), largely depend on the super-structure, which is that between the federal government and the lower tiers. The implication is that the level of autonomy enjoyed by local governments largely depends on the level of autonomy the states themselves enjoy.
DOI: 10.6084/m9.figshare.11609145
title: Update on Management of Postoperative Atrial Fibrillation After Cardiac Surgery

description: Abstract Postoperative atrial fibrillation (POAF) after cardiac surgery remarkably remains the most prevalent event in perioperative cardiac surgery, having great clinical and economic implications. The purpose of this study is to present recommendations based on international evidence and adapted to our clinical practice for the perioperative management of POAF. This update is based on the latest current literature derived from articles and guidelines regarding atrial fibrillation.
DOI: 10.6084/m9.figshare.11609148.v1
title: Social Accountability of Medical Schools and Social Representations of Medical Students in the Context of the More Doctors Program

description: ABSTRACT Several debates, in the national and international context, have suggested the need for changes in medical education, so that it is in line with the organization of health systems. From this perspective, it is proposed that schools be guided by social accountability, which consists of ordering teaching, research and activities in service to meet health needs with a focus on areas that are difficult to reach. A more recent reference in medical education at the national level was the More Doctors Program, which provided for a new regulatory framework for medical education. It is evaluated that the modifications introduced by the Program can influence the elaboration of new social representations of medical students. Through the theory of social representations, a qualitative study was carried out to analyze the perception about the social accountability of the medical schools of 149 medical students, of the seventh semester of four courses of Federal Higher Education Institutions in the Northeast Region. Two of the courses are in the interior and were created by virtue of the More Doctors Program and another two correspond to courses in the state capital existing for more than 60 years. From the curriculum analysis of each course, they were termed “traditional” or “new”. In the results, it was observed that the students of the different courses resemble each other in terms of admission by quotas, but students of “new” courses have a greater entrance under affirmative action policies, including regional access criteria. Both groups of students have emphasized the term “duty” as a priority, which may refer to a more individual scope of the notion of accountability. The terms “citizenship” and “ethics” were also highlighted in both groups. Only for students in “new” schools were terms such as “commitment”, “justice” and “SUS” cited. This insight suggests a broader notion of social accountability in school students created under the More Doctors Program, despite insufficient national literature on this topic. The conclusion emphasizes the importance of the Program in the implantation of medical schools in regions that did not previously have this training. It also reinforces the relevance of the dedication of the teachers who implemented the courses in the interior of the Northeast, demonstrating the need to deepen in the themes that involve teacher development. It is suggested that there is a need to broaden the analysis of experiences such as these, so that they can be explored with the radicalism necessary to strengthen the Unified Health System.
DOI: 10.6084/m9.figshare.11609145.v1
title: Update on Management of Postoperative Atrial Fibrillation After Cardiac Surgery

description: Abstract Postoperative atrial fibrillation (POAF) after cardiac surgery remarkably remains the most prevalent event in perioperative cardiac surgery, having great clinical and economic implications. The purpose of this study is to present recommendations based on international evidence and adapted to our clinical practice for the perioperative management of POAF. This update is based on the latest current literature derived from articles and guidelines regarding atrial fibrillation.
DOI: 10.6084/m9.figshare.11609139
title: Bioterrorism: empower to respond

description: ABSTRACT The use of biological agents for the purpose of terrorizing enemies dates back many centuries. This terror action with the use of biological agents became popularized as Bioterrorism. Bioterrorist attacks are dangerous due to various factors involved, such as the silent way in which it may occur, or the type of biological agent that can be used depending on the purpose of the attack. To prevent contamination by these agents, the professionals who will act to combat these events should have knowledge about the varieties of mechanisms of actions and dissemination of the pathogens, as well the best way to neutralize and eliminate them; besides, they should have known how to choose appropriates protection equipment, both for individual and collective protection. Thus, it is necessary that such action teams be well empowered and trained. The purpose of this paper is to analyze, in the existing literature, what are the training modes in the world for first responders to attacks involving Chemical, Biological, Radiological or Nuclear (CBRN) agents. Thus, an integrative review was made based on 3 articles found in a period of 20 years. It is concluded that studies in this field are minimals and that more research and training for this kind of event should be carried out worldwide.