cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.28473312.v1
title: Heavy chain variants affect light and heavy chains assembly of monoclonal antibody expressed by <i>Pichia pastoris</i>

description: Monoclonal Antibody accounts for the largest share of recombinant protein drugs and is the primary choice for the treatment of various diseases. In this study, the monoclonal antibody Eptinezumab was expressed by a yeast host <i>Pichia pastoris</i>. Although the expression and secretion of light chain was efficient, the assembly efficiency between light and heavy chains was low. As the retention of the heavy chain in endoplasmic reticulum may trigger protein degradation, ERAD ubiquitination-related genes were then knocked out separately but it only led to minor improvement effect. Expression of splitted heavy chain variants further revealed that although endoplasmic reticulum retention of the heavy chain upregulated KAR2 expression, it did not affect the assembly efficiency of the light and heavy chains. It was inferred that binding of complete heavy chains to KAR2 spatially affected the assembly between light and heavy chains. Design and screening of KAR2 variants that facilitating full-length antibody assembly could be preferentially considered in future.
DOI: 10.15468/dl.hazqva
title: Occurrence Download

description: A dataset containing 526 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Tibetiodes diplostephioides"
 ]
}

 The dataset includes 526 records from 31 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0014539-250827131500795/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.sjm66e
title: Occurrence Download

description: A dataset containing 58 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is Ecuador",
 "Geometry POLYGON((-121.45406 -21.79899,-22.54594 -21.79899,-22.54594 17.79899,-121.45406 17.79899,-121.45406 -21.79899))",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 "PublishingOrg is one of (90fd6680-349f-11d8-aa2d-b8a03c50a862, 8e1a97a0-3ca8-11d9-8439-b8a03c50a862, bc092ff0-02e4-11dc-991f-b8a03c50a862, 396d5f30-dea9-11db-8ab4-b8a03c50a862, e1f3033f-176a-4e5e-8b97-7f1f000fcc2a, 061b4f20-f241-11da-a328-b8a03c50a862, 838537fc-4aeb-4980-8b58-97fbdcd1d91a, f0b6a090-a4c6-11d8-9534-b8a03c50a862)",
 "TaxonKey is Lepechinia bullata"
 ]
}

 The dataset includes 58 records from 9 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0014540-250827131500795/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.583de7
title: Occurrence Download

description: A dataset containing 96 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is Costa Rica",
 "TaxonKey is Mucuna urens"
 ]
}

 The dataset includes 96 records from 20 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0014541-250827131500795/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.q94m2e
title: Occurrence Download

description: A dataset containing 2 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is Peru",
 "Geometry POLYGON((-135.13719 -39.04163,-14.86281 -39.04163,-14.86281 9.04163,-135.13719 9.04163,-135.13719 -39.04163))",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 "TaxonKey is Bursa ventricosa"
 ]
}

 The dataset includes 2 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0014542-250827131500795/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.v7cjxr
title: Occurrence Download

description: A dataset containing 274 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Myosotis alpestris"
 ]
}

 The dataset includes 274 records from 38 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0014543-250827131500795/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.57760/sciencedb.j00253.01404
title: Study on the Correlation Between Airborne Pollen Concentration and Allergic Rhinitis in Dalian City and Its Impact
title: 2024年大连市气传花粉浓度与变应性鼻炎的相关性及其影响研究

description: OBJECTIVE To systematically investigate the spatiotemporal distribution of airborne pollen in Dalian (2024) and analyze its correlation with meteorological factors, air pollutants, and allergic rhinitis (AR) consultations, providing evidence for regional allergy prevention.METHODS Daily pollen samples were collected from July 9 to October 15, 2024, using gravimetric sedimentation. Pollen types were identified and quantified via optical microscopy after staining. Concurrent meteorological data (temperature, relative humidity, wind speed) and air pollutant levels (PM2.5, PM10, SO₂, NO₂) were obtained. AR case data were extracted from the Hospital Information System (HIS) of Dalian University Affiliated Zhongshan Hospital. Multivariate linear regression was employed to assess correlations.CONCLUSION AR incidence in Dalian is closely linked to seasonal pollen patterns, modulated by meteorological and pollutant interactions. Establishing a pollen monitoring system could optimize allergy prevention strategies.
description: OBJECTIVE To systematically investigate the spatiotemporal distribution of airborne pollen in Dalian (2024) and analyze its correlation with meteorological factors, air pollutants, and allergic rhinitis (AR) consultations, providing evidence for regional allergy prevention.METHODS Daily pollen samples were collected from July 9 to October 15, 2024, using gravimetric sedimentation. Pollen types were identified and quantified via optical microscopy after staining. Concurrent meteorological data (temperature, relative humidity, wind speed) and air pollutant levels (PM2.5, PM10, SO₂, NO₂) were obtained. AR case data were extracted from the Hospital Information System (HIS) of Dalian University Affiliated Zhongshan Hospital. Multivariate linear regression was employed to assess correlations.CONCLUSION AR incidence in Dalian is closely linked to seasonal pollen patterns, modulated by meteorological and pollutant interactions. Establishing a pollen monitoring system could optimize allergy prevention strategies.
DOI: 10.57760/sciencedb.j00253.01396
title: A Cross-Sectional Study on the Self-Management Status of Asthma Patients Under Different Follow-Up and Medication Dispensing Models
title: 不同随访配药方式哮喘患者自我管理现状的横断面研究

description: Cross sectional study on self-management status of asthma patients with different follow-up medication dispensing methods and related charts 
description: Cross sectional study on self-management status of asthma patients with different follow-up medication dispensing methods and related charts
DOI: 10.57760/sciencedb.j00253.01276
title: Associations of cat allergens with related allergic diseases
title: 猫变应原与过敏性疾病的关联

description: Cat allergens are one of the most important environmental factors which contribute to the development of allergic diseases. The global popularity of pet cat ownership in recent years has led to an increase in the incidence of allergic diseases associated with cat allergens. Studies have shown that pet cats can induce type I hypersensitivity-related diseases such as allergic rhinitis, asthma, and atopic dermatitis in atopic individuals through allergens present in their dander, saliva, urine, and other substances. Currently, the specific mechanism by which cat allergens induce immune tolerance is not fully understood. In addition, due to multiple sensitization and cross-reactivity, the effects of cat allergens interacting with other pet allergens (e.g., dog allergens) and air pollutants on the development of allergic diseases are unclear. Therefore, this review summarized recent advances in the epidemiology of cat allergens sensitization, underlying mechanisms, cat allergens exposure and sensitization risk, component resolved diagnostics, treatment, and prevention, aiming to provide references for clinical strategies in prevention, diagnosis and management.
description: Cat allergens are one of the most important environmental factors which contribute to the development of allergic diseases. The global popularity of pet cat ownership in recent years has led to an increase in the incidence of allergic diseases associated with cat allergens. Studies have shown that pet cats can induce type I hypersensitivity-related diseases such as allergic rhinitis, asthma, and atopic dermatitis in atopic individuals through allergens present in their dander, saliva, urine, and other substances. Currently, the specific mechanism by which cat allergens induce immune tolerance is not fully understood. In addition, due to multiple sensitization and cross-reactivity, the effects of cat allergens interacting with other pet allergens (e.g., dog allergens) and air pollutants on the development of allergic diseases are unclear. Therefore, this review summarized recent advances in the epidemiology of cat allergens sensitization, underlying mechanisms, cat allergens exposure and sensitization risk, component resolved diagnostics, treatment, and prevention, aiming to provide references for clinical strategies in prevention, diagnosis and management.
DOI: 10.57760/sciencedb.j00253.00547
title: CDYL-mediated H3K18 crotonylation upregulates SGK1 to promote vascular smooth muscle cell phenotypic switching
title: CDYL介导组蛋白H3K18巴豆酰化修饰上调SGK1促进血管平滑肌细胞表型转换

description: Objective Aortic dissection and aortic aneurysm pose severe threats to patient life and health, with vascular smooth muscle cell (VSMC) phenotypic switching serving as a critical pathological event. Histone modifications have been demonstrated to regulate VSMC phenotypic plasticity. This study aims to investigate the role and underlying mechanism of histone crotonylation in VSMC phenotypic switching.Methods Comprehensive analyses were performed using Western blot, reverse transcription quantitative polymerase chain reaction (RT-qPCR), gene knockdown/overexpression, and chromatin immunoprecipitation (ChIP) assays.Results During VSMC phenotypic switching, chromatin-bound protein Y (CDYL) was significantly downregulated, while histone H3 lysine 18 crotonylation (H3K18cr) modification and serum/glucocorticoid-regulated kinase 1 (SGK1) expression were upregulated and negatively regulated by CDYL.Conclusion This study demonstrates that CDYL downregulation promotes H3K18cr-mediated epigenetic activation of SGK1, thereby driving VSMC phenotypic switching. These findings provide novel therapeutic targets and conceptual frameworks for the clinical prevention and treatment of aortic dissection and aneurysm.
description: Objective Aortic dissection and aortic aneurysm pose severe threats to patient life and health, with vascular smooth muscle cell (VSMC) phenotypic switching serving as a critical pathological event. Histone modifications have been demonstrated to regulate VSMC phenotypic plasticity. This study aims to investigate the role and underlying mechanism of histone crotonylation in VSMC phenotypic switching.Methods Comprehensive analyses were performed using Western blot, reverse transcription quantitative polymerase chain reaction (RT-qPCR), gene knockdown/overexpression, and chromatin immunoprecipitation (ChIP) assays.Results During VSMC phenotypic switching, chromatin-bound protein Y (CDYL) was significantly downregulated, while histone H3 lysine 18 crotonylation (H3K18cr) modification and serum/glucocorticoid-regulated kinase 1 (SGK1) expression were upregulated and negatively regulated by CDYL.Conclusion This study demonstrates that CDYL downregulation promotes H3K18cr-mediated epigenetic activation of SGK1, thereby driving VSMC phenotypic switching. These findings provide novel therapeutic targets and conceptual frameworks for the clinical prevention and treatment of aortic dissection and aneurysm.
DOI: 10.57760/sciencedb.j00253.00466
title: Associations of cat allergens with related allergic diseases
title: 猫变应原与相关过敏性疾病的关联

description: Cat allergens are one of the most important environmental factors which contribute to the development of allergic diseases. The global popularity of pet cat ownership in recent years has led to an increase in the incidence of allergic diseases associated with cat allergens. Studies have shown that pet cats can induce type I hypersensitivity-related diseases such as allergic rhinitis, asthma, and atopic dermatitis in atopic individuals through their dander, saliva, urine, and other allergens. However, the relationship between cat allergens exposure and the development of allergic diseases remains unclear, and the specific mechanisms by which they induce immune tolerance are not fully understood. In addition, due to multiple sensitization and cross-reactivity, the effects of cat allergens interacting with other pet allergens (e.g., dog allergens) and air pollutants on the development of allergic diseases are unclear. Therefore, this review summarized recent advances in the epidemiology of cat dander allergy, sensitization mechanisms, cat allergens exposure and sensitization risk, component resolved diagnostics, treatment, and prevention, aiming to provide references for clinical strategies in prevention, diagnosis and management.
description: Cat allergens are one of the most important environmental factors which contribute to the development of allergic diseases. The global popularity of pet cat ownership in recent years has led to an increase in the incidence of allergic diseases associated with cat allergens. Studies have shown that pet cats can induce type I hypersensitivity-related diseases such as allergic rhinitis, asthma, and atopic dermatitis in atopic individuals through their dander, saliva, urine, and other allergens. However, the relationship between cat allergens exposure and the development of allergic diseases remains unclear, and the specific mechanisms by which they induce immune tolerance are not fully understood. In addition, due to multiple sensitization and cross-reactivity, the effects of cat allergens interacting with other pet allergens (e.g., dog allergens) and air pollutants on the development of allergic diseases are unclear. Therefore, this review summarized recent advances in the epidemiology of cat dander allergy, sensitization mechanisms, cat allergens exposure and sensitization risk, component resolved diagnostics, treatment, and prevention, aiming to provide references for clinical strategies in prevention, diagnosis and management.
DOI: 10.15468/dl.b475w6
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Carduus crispus"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0014544-250827131500795/datasets/export for details.
DOI: 10.15468/dl.28cf48
title: Occurrence Download

description: A dataset containing 1366 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is Argentina",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "TaxonKey is Cinclus"
 ]
}

 The dataset includes 1366 records from 10 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0014545-250827131500795/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.34740/kaggle/dsv/12925763
title: Market Prices of Commodities in South Tangerang
DOI: 10.15468/dl.jhztrb
title: Occurrence Download

description: A dataset containing 31919 species occurrences available in GBIF matching the query:
{
 "and" : [
 "BasisOfRecord is Specimen",
 "TaxonKey is Lithobates catesbeianus"
 ]
}

 The dataset includes 31919 records from 167 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0014546-250827131500795/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.s4kt94
title: Occurrence Download

description: A dataset containing 1747 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Carduus crispus"
 ]
}

 The dataset includes 1747 records from 18 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0014547-250827131500795/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.p3pb4u
title: Occurrence Download

description: A dataset containing 68 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is Costa Rica",
 "TaxonKey is Muellera monilis"
 ]
}

 The dataset includes 68 records from 8 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0014548-250827131500795/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.pxbkvb
title: Occurrence Download

description: A dataset containing 243 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is Argentina",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "TaxonKey is Anthus nattereri"
 ]
}

 The dataset includes 243 records from 3 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0014549-250827131500795/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.6084/m9.figshare.29885930.v28
title: Logic 14 pdf NEW

description: Logic innovation
DOI: 10.15468/dl.9cxs63
title: Occurrence Download

description: A dataset containing 1747 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Carduus crispus"
 ]
}

 The dataset includes 1747 records from 18 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0014550-250827131500795/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.34740/kaggle/dsv/12925776
title: Booru.org Top Leaderboard
DOI: 10.15468/dl.z4aakz
title: Occurrence Download

description: A dataset containing 4982 species occurrences available in GBIF matching the query:
{
 "DatasetKey" : [
 "is Registros biológicos de especies de fauna vertebrada terrestre en las centrales de San Carlos y Jaguas - 2007"
 ]
}

 The dataset includes 4982 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0014551-250827131500795/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.gnr8r5
title: Occurrence Download

description: A dataset containing 778 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Heracleum candicans"
 ]
}

 The dataset includes 778 records from 42 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0014552-250827131500795/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.v7w5ta
title: Occurrence Download

description: A dataset containing 358 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is Argentina",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "TaxonKey is Spizaetus isidori"
 ]
}

 The dataset includes 358 records from 4 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0014553-250827131500795/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.5281/zenodo.17014565
title: Resolution of the Poincaré Conjecture via Vacuum Lattice Harmonic (VLH) Orthogonal Rigidity: A Spectral Operator-Theoretic Framework

description: This work presents a rigorous operator-theoretic re-proof of the Poincaré Conjecture within the Vacuum Lattice Harmonic (VLH) framework. The classical conjecture, resolved by Perelman via Ricci flow with surgery, is reformulated through spectral orthogonal decomposition, embedding compact 3-manifolds into a recursive conservation–dissipation lattice. The VLH formalism defines dual spectral bands—conservative low-frequency harmonic modes and dissipative high-frequency modes—governed by an operator energy law isomorphic to the First Law of Thermodynamics. Within this structure, non-spherical modes decay exponentially, while the unique fixed-point attractor under recursion corresponds to S^3. We prove Orthogonal Rigidity: any simply connected compact 3-manifold reduces under VLH recursion to the spherical 3-lattice, yielding a homeomorphism M^3 \cong S^3. This provides an independent proof strategy aligning thermodynamic meta-symmetry with geometric topology.

 

The framework strengthens Perelman’s geometric approach by embedding Ricci-type curvature flow into a spectral operator model, emphasizing recursion stability, spectral rigidity, and orthogonal band dualities. Beyond topology, the results demonstrate that VLH recursion unifies multiple Clay Millennium Problems—Yang–Mills mass gap, Navier–Stokes global regularity, and P \neq NP—as spectral classification theorems under a universal conservation/dissipation law.

 

Keywords: Poincaré Conjecture, Vacuum Lattice Harmonic (VLH), spectral operator theory, orthogonal rigidity, Ricci flow, geometric topology, Clay Millennium Problems, thermodynamic conservation law, spectral duality, recursive harmonic lattices.
DOI: 10.5281/zenodo.17014566
title: Resolution of the Poincaré Conjecture via Vacuum Lattice Harmonic (VLH) Orthogonal Rigidity: A Spectral Operator-Theoretic Framework

description: This work presents a rigorous operator-theoretic re-proof of the Poincaré Conjecture within the Vacuum Lattice Harmonic (VLH) framework. The classical conjecture, resolved by Perelman via Ricci flow with surgery, is reformulated through spectral orthogonal decomposition, embedding compact 3-manifolds into a recursive conservation–dissipation lattice. The VLH formalism defines dual spectral bands—conservative low-frequency harmonic modes and dissipative high-frequency modes—governed by an operator energy law isomorphic to the First Law of Thermodynamics. Within this structure, non-spherical modes decay exponentially, while the unique fixed-point attractor under recursion corresponds to S^3. We prove Orthogonal Rigidity: any simply connected compact 3-manifold reduces under VLH recursion to the spherical 3-lattice, yielding a homeomorphism M^3 \cong S^3. This provides an independent proof strategy aligning thermodynamic meta-symmetry with geometric topology.

 

The framework strengthens Perelman’s geometric approach by embedding Ricci-type curvature flow into a spectral operator model, emphasizing recursion stability, spectral rigidity, and orthogonal band dualities. Beyond topology, the results demonstrate that VLH recursion unifies multiple Clay Millennium Problems—Yang–Mills mass gap, Navier–Stokes global regularity, and P \neq NP—as spectral classification theorems under a universal conservation/dissipation law.

 

Keywords: Poincaré Conjecture, Vacuum Lattice Harmonic (VLH), spectral operator theory, orthogonal rigidity, Ricci flow, geometric topology, Clay Millennium Problems, thermodynamic conservation law, spectral duality, recursive harmonic lattices.