cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.14457/cu.the.2010.723
title: Plasma polymerization and iodine doping of thiophene derivatives

description: Plasma polymerization of poly(2-methylthiophene) and poly(3-methylthiophene) thin films have been synthesized. Plasma polymerization parameters were studied. Microwave power in the range of 350-450 W was employed for 2 minutes. Plasma-polymerized poly(2-methylthiophene) and plasma-polymerized poly(3-methylthiophene) films were characterized by various spectrophotometric methods. Infrared analyses showed absorption frequencies of important functional groups mostly similarly observed in the case of monomer. Results from Energy-dispersive X-ray spectroscopy analysis were suggestive of partial fragmentation of the films. The C/S ratio of plasma-polymerized poly(2-methylthiophene) is lower than the theoretical value. For the plasma-polymerized poly(3-methylthiophene), the C/S ratio is equal to or higher than theoretical value. Electrical conductive measurements revealed that the plasma-polymerized poly(2-methylthiophene) and the plasma-polymerized poly(3-methylthiophene) films exhibit conductivities 1.04 x 10⁻⁸ to 1.20 x 10⁻⁷ and 1.05 × 10⁻⁷ to 2.01 × 10⁻⁷ S/cm, respectively. As for the doped plasma-polymerized poly(2-methylthiophene) and plasma-polymerized poly(3-methylthiophene) materials, initial conductivities (2.29 × 10⁻⁵ and 1.85 × 10⁻⁵ S/cm, respectively) were lower than the plasma-polymerized films which were doped with the conventional method. However, it was found that conductivity of the latter decreased more rapidly and reached an undoped value in a short time (24 hours). In contrary, the decaying rate of conductivity of in situ doped material could be sustained for a longer period of time (more than 160 hours).
DOI: 10.14457/cu.the.2010.724
title: Preparation of glucosamine-loaded alginate-chitosan nanoparticles

description: Glucosamine-loaded nanoparticles were prepared based on ionotropic gelation method using calcium ion, alginate, and chitosan or two chitosan derivatives that carried permanent positively charged ammonium groups. The two derivatives synthesized in this work were N,N,N-trimethylammonium chitosan chloride (TMC) with degree of quaternization (DQ) of 35% and N-[(2-hydroxyl-3-trimethylammo-nium)propyl]chitosan chloride (HTCC) with DQ of 11 and 33%. Appling the sonication time up to 20 min caused the reduction of particle size by 36.8%. In this work however no direct relationship between the molecular weight of chitosan and the particles size was observed. At the same concentration of cationic polymers, the use of HTCC tended to give smaller particles size than did the chitosan or TMC. The HTCC with high DQ (33%) when incorporated with alginate gave smaller particle size than the one with lower DQ (11%). The amount of glucosamine released was analyzed using HPLC technique. The release profiles of all particle types with show linear relationship between the cumulative amount of GH release and time in the course of 360 min. No ‘burst’ effect was also observed in these particle systems. The particle had a core-shell feature as characterized by TEM
DOI: 10.14457/cu.the.2010.725
title: Polydiacetylene from diacetylene lipids containning oligo(ethylene glycol) as thermal and metal ion sensors

description: Three ethylene glycol esters and one ethanolamide derivatives of 10,12-pentacosadiynoic acid (PCDA) were synthesized and studied as a modulator for poly(PCDA) sensor. Ethylene glycol (EG-PCDA), triethylene glycol (3EG-PCDA) and pentaethylene glycol esters (5EG-PCDA) were synthesized by simple acid catalyzed esterification of PCDA with ethylene glycol and the corresponding oligo(ethylene glycol). The preparation of the amide derivative, NEG-PCDA, was performed via a condensation between the methyl ester of PCDA and ethanolamine. The mixed lipids between PCDA and its derivative can be dispersed in milli-Q water by ultrasonication, giving translucent sol. After being irradiated with UV light, the mixed lipid sols undergo photopolymerization to generate the desired blue polydiacetylene (PDA) sols. The blue to red thermochromic transition of PDA sols were monitored by observing the absorbance of the red phase of PDA at 540 nm in the range of 20-80 C using temperature variable UV-vis spectrometer. The derivative (dA/dT) plot of the PDA sols containing diacetylene esters showed two steps of color transition while the PDA sol containing diacetylene amide exhibited continuous one-stepped color transition. In the two-stepped color transition, the second step observed around 65 °C associated with the color transition temperature of poly(PCDA). The PDA sols containing 30% mole of the diacetylene esters were assessed for colorimetric detection of heavy metal ions such as Cd²⁺, Co²⁺, Cu²⁺, Fe²⁺, Hg²⁺, Ni²⁺, Pb²⁺ and Zn²⁺. At 100 µM, only Pb²⁺ caused a distinct color change of the sol from blue to red for the PDA sol of 5EG-PCDA/PCDA mixed lipid. The sol showed the detection limit of Pb²⁺ as low as 10 µM (~2 ppm).
DOI: 10.14457/cu.the.2010.726
title: Synthesis of quinazoline derivatives with acetycholinesterase and butyrylcholinesterase inhibitory activities

description: Quinazolines were the attractive and useful compounds in medicinal chemistry due to their pharmacology activities such as antibacterial, anticancer, antitumor, antidiabetic, anti-inflammatory, analgesic and antiviral activities. In this study, the acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitory activities of quinazolines derivatives were evaluated. The 4-substitued aminoquinazolines via amination reaction were first synthesized and found that 4-piperidinoquinazolines (12e) possess the highest activity with the IC₅₀ values toward AChE and BChE of 1.3 µM and 7.5 µM, respectively. Then 4-butylaminoquinazolin (12a), 4-piperidinoquinazolines (12e) and 4-morpholinoquinazoline were chosen for further modified their structures by the electron-withdrawing and electron-releasing groups. From the results, there is no activity trend from these groups as substituents on a benzene ring of the core structures of 12a, 12e and 12f. These might be the cause of the different mode of action in each compound. However, this study 4-piperidinoquinazolines (12e) was a candidate for both AChE and BChE inhibitors. 6-Nitro-4-butylaminoquinazoline (16a) was a potent and selective inhibitor toward AChE over BChE while 6,7-dimethoxy-4-butylaminoquinazoline (16d) was a potent and selective inhibitor toward BChE over AChE.
DOI: 10.14457/cu.the.2010.727
title: Nonequilibrium quantum field theory in cosmology

description: Nonequilibrium quantum field theory has recently become an important tool in research in particle physics and cosmology. The salient feature of nonequilibrium quantum field theory is its formalism which treats the propagators as independent variables. In this thesis, the formulation of nonequilibrium quantum field theory, consisting of the closed-time path integral and the 2-particle-irreducible formalism, is reviewed. The methods are then applied to the study of inflaton dynamics in curved spacetime, with and without fermion coupling, and the dynamical equations for the inflaton mean field and propagators are derived. It is found that these equations respect causality and have the potential of predicting the inflaton damping and the fermion production, even though their solution cannot be obtained analytically.
DOI: 10.17632/9rc79r8nyw.1
title: Humor types and emotion regulation in remitted depression.

description: This experiment was aimed to investigate humor - as an emotion regulation strategy - and compared the effects of its two specific forms: humor related to distress and humor unrelated to distress. We predicted that humor related to distress, because of its mechanism involving a dramatic reinterpretation of a distressing issue, is more adaptive than humor unrelated to distress. Remitted depressed outpatients (N = 122) were recruited to the study after psychiatric assessment, structuralised diagnostic interview (SCID I), and BDI II fullfilment. In addition, participants underwent neuropsychological assessments with the use of the d2 Test of Attention. The experiment consisted of a personal distress elicitation and subsequent application of one of three emotion regulation strategies (two humor conditions and one control condition). Each emotion regulation strategy involved the generation of a scenario - a simulation of events corresponding to one of three experimental conditions. Next, there was a manipulation check - participants were asked whether they were able to produce tha target scenario (yes/sort of/no) in terms of its level of subjective funniness and connection to ones's own distress. Finally, 17 participants were excluded from the analyses as outliers or extremes on the basis of boxplot, and 11 participants were excluded due to ineffectiveness of experimental manipulation. Then positive emotions, negative emotions, and experienced distress were measured (based on self-reports: single VAS scales from 0 - no intensity to 6- extremely high intensity) at four time points: before stress induction (T1), after distress induction (T2), immediately after manipulation (T3), and after 20 minutes delay (during which the participants watched a nature film and fulfilled the test of understanding the film content). In addition, in T3 there was a single assessment of invested efforts, while in T4 a subsequent performances and intrusive thoughts were measured. The main analysis was performed with the use of RMANOVA. Conditions were analysed as beetwen-subject fixed factor and intensity of emotions as within-subject factors. The level of depressive symptoms was included as covariate. Unlike rational simulation, both humor types improved emotional experience, and reduced distress in the short and longer terms. Humor unrelated to distress more effectively reduced negative emotions and intrusive thoughts. Moreover, although patients with impaired sustained attention did not recover their initial level of negative emotions, this did not pertain to those from humor unrelated to distress condition. Despite the expected costs of humor, similar efforts were needed when compared to control condition and no performance impairment after using both humor types was found. The results suggest that humor, expecially the one unrelated to distress, could be a beneficial strategy for dealing with distressing events in remitted depression.
DOI: 10.25345/c54q00
title: MassIVE MSV000084237 - Siderophore Standard Mixture with metal additions
title: Siderophore standards were run in the presence and absence of metals to test metal-binding methods.
DOI: 10.5281/zenodo.3378068
title: DWD European Weather 2

description: opendata.dwd.de - OpenData by Deutscher Wetter Dienst Conditions: https://www.dwd.de/EN/service/copyright/copyright_node.html dates and times are UTC.
DOI: 10.7910/dvn/gnxxls/nhjgpq
title: bla.json

description: My description.
DOI: 10.7910/dvn/l0mng4/xzhhdg
title: Anderson-Henrique-ad-ufpe-2019.R

description: Script da análise de dados do arquivo
DOI: 10.14457/cu.the.2010.728
title: Synthesis of phosphorodiamidates as crosslinking agent for epoxy resin

description: Two phosphorodiamidates including phenyl phosphonic ethylene diamine diamide (PPEDD) and phenyl phosphonic p-phenylene diamine diamide (PPPDD) have been synthesized and used as crosslinking agents for the preparation of phosphorus-nitrogen-containing epoxy polymers. The investigation of kinetics revealed that activation energy for crosslinking reaction of epoxy resins cured with phosphorodiamidates were higher than crosslinking reaction of epoxy resins cured with ethylenediamine and cured with p-phenylenediamine which were employed as references. The results from TGA experiments indicated that the onset temperature of thermal degradation decreased but char yield increased when epoxy resins were cured with phosphorodiamidates. Limiting Oxygen Index (LOI) results demonstrated that flame resistances of phosphorus-containing polymers are higher than those of ethylenediamine-cured and p-phenylenediamine-cured epoxy resins. Smoke evolution is also reduced. The results obtained from the UL-94 tests show that phosphorus-containing polymers passed flame retarding class V according to the UL-94 standard. The investigations of mechanical properties were that epoxy resins cured with phosphorodiamidates give lower tensile strength, but better elongation at break than epoxy resins cured with ethylenediamine and cured with p-phenylenediamine where no phosphorus were present.
DOI: 10.14457/cu.the.2010.729
title: Gene cloning, expression and characterization of lipase from Fusarium Solani for the production of biodiesel

description: Biodiesel is the product derived from triglycerides by transesterification catalyzed by acid or base. However, biological catalyst such as lipase has become more attractive. The screening for natural microbial lipases with the transesterification activities together with gene technology can therefore be applied to develop and increase the production of large quantities of the enzyme. In this research, the lipase gene was cloned from lipase producing fungus namely, Fusarium solani into the pPICZαA. The result revealed that the gene was composed of 1,002 bp and could be deduced into 333 residues of amino acids. The lipase gene was then transformed and expressed in Pichia pastoris strain KM71. It was found that the incubation in the presence of 3 % of methanol at 30 °C for 5 days was optimal for the induction of the expression. The expressed recombinant lipase was subsequently purified and 2.5 purification folds with the molecular weight of approximately 40 kDa were obtained. The study of substrate specificity showed that the enzyme was specific towards the substrates with carbon chain lengths between 4-14. The optimal conditions were found to be pH 9 at 35-40 °C while the enzyme was stable at pH between 5.0-10.0 and the temperature below 35 °C. The effect of chemicals revealed that the activity of recombinant lipase was not influenced by most studied metal ions and detergents but strongly inhibited by SDS and reducing agent, β- mercaptoethanol. When the recombinant lipase was tested for the hydrolysis of 7 types of plant oils including coconut, rambutan, palm, papaya, olive, physic nuts and safflowers, the highest specific activity of 1.14 μmol/min/mg protein was obtained from the coconut oil as substrate. Finally, the transesterification of 4 types of oils with high hydrolytic activities ie. coconut, rambutan, palm and papaya was investigated. The results indicated that approximately 45% of biodiesel were obtained from rambutan oil which was higher than papaya, palm and coconut respectively. From this study, it could therefore be concluded that lipase gene from Fusarium solani was successfully cloned and expressed. The obtained recombinants could catalyze both the hydrolysis and transesterification for the production of biodiesel.
DOI: 10.14457/cu.the.2010.730
title: Preparation of aminopropyl functionalized silica fiber for adsorption of formaldehyde in water

description: The silica fibers can be applied for adsorption of formaldehyde which had been classified as a carcinogen in human. In this study, silica fibers were fabricated by electrospinning technique via sol-gel process. Many factors that affect the morphology of electrospun fibers including the distance between syringe needle and collection screen, as well as electric potential were studied. The optimized distance and electric potential were 10 cm and 15 kV, respectively. The diameter of the needle of 0.8 mm and flow rate 20 µL/min were selected for the optimum condition for preparation of electrospun silica fibers. The Scanning Electron Microscope (SEM) images illustrated that most of silica fibers were smooth and straight with diameters in the range of 200-270 nm. For preparation of functionalized silica fibers, 3-aminopropyltriethoxysilane (APTES) was used for aminopropyl functionalization. Characterization with thermogravimetry, surface area analysis, elemental analysis and Infrared spectroscopy showed the clear difference between aminopropyl functionalized on electrospun fibrous silica mats and non-functionalized electrospun silica fibers. It could conclude that aminopropyl group could be successfully grafted on electrospun silica fibers. Using 0.15 M APTES for functionalization of silica fibers with APTES and subsequent adsorption of formaldehyde in water for 3 hours were the optimum method. In the part of elution, the optimum condition was using hydrochloric acid or sulfuric acid with concentration of 0.1 M and elution for 15 minutes.
DOI: 10.14457/cu.the.2010.731
title: Synthesis and molecular modeling of new multi-cinnamy as hiv-1 integrase inhibitors

description: Twenty one multi-cinnamoyl-based analogs on the hexasubstituted benzene platform were synthesized and tested as a new group of synthetic inhibitors of HIV-1 integrase (IN). They were prepared from the Claisen-Schmidt condensations of 335 and the corresponding substituted benzaldehydes in various ranges of yields (3-49%). Partial demethylations of the methoxy groups on the flanking phenyl rings gave the free phenolic or catecholic moieties. The most potent compound 353 showed the inhibition activity against HIV-1 integrase in multiplate integration assay (MIA) with IC₅₀ value of 3.5 µM. To understand the binding of these inhibitors to HIV-1 IN, the flexible models of selected 21 multi-cinnamoyl compounds were computationally docked into the catalytic core domain of HIV-1 IN using Autodock 4.0 program. The obtained docking parameters, mainly hydrogen bonding and binding energy, can be used to explain biological activity of most compounds. In general, it is found that active inhibitors forms more hydrogen bonds with IN than inactive analogs.
DOI: 10.14457/cu.the.2010.732
title: Effects of cholesterol-loaded cyclodextrins on quality of equine epididymal sperm after freezing and thawing

description: The objectives of this study were to examine the effects of cholesterol-loaded cyclodextrins (CLCs) on amount and distribution of cholesterol in equine epididymal sperm (EXP.1, EXP.2), and to study the effect of CLCs on quality of epididymal sperm during cryopreservation. EXP.1Sperm from Thai crossbreed stallions (n=3, aged 3-12 years old) were loaded with three concentrations of CLCs: 1) 1.5 mg, 2) 3 mg, and 3) 6 mg of CLCs per 120x10⁶ sperm. The CLCs loaded sperm were then analyzed for the amount of total cholesterol in the sperm plasma membrane at 15, 30 and 45 min of CLC incubation using gas chromatography. Sperm incubated in extender without CLCs served as a control.The cholesterol contents in epididymal sperm were increased in a manner of dose and time dependence. Incubating sperm with 1.5 mg CLCs/120 x 10⁶ sperm preserved sperm quality similar to non-CLC treated control (P&gt;0.05). However, high CLC concentration, especially at 6 mg/ 120 x 10⁶, significantly decreased sperm motility and viability in all incubation times. EXP.2 Sperm from Thai crossbreed stallions (n=3, aged 3-12 years old) were treated with 1.5 mg CLCs/ 120x10⁶ sperm. After 15 min, the sperm were fixed and stained with filipin to examine the cholesterol distribution. Filipin-sterol complexes were distributed throughout the sperm head with a lower intensity at apical and pre-equatorial subdomains of non-CLC treated sperm. In CLC treated sperm, two patterns of filipin-sterol complexes were predominantly detected. A large proportion of CLCs treated sperm (64.3 ± 2.8%) had a marked increase of filipin-sterol complex intensity over the sperm head compared to non-CLC treated sperm. However, 27.7 ± 3.2% of sperm demonstrated an absent or patchy labeling of filipin at apical and pre-equatorial parts. Small number of sperm (8.0 ± 4.6%) had pattern of filipin-sterol complexes similar to that of non-treated control. EXP.3 Epididymal sperm from Thai crossbreed stallions (n=7, aged 3-12 years old) were treated with CLCs as similar to EXP.1 and then submitted to cryopreservation. The sperm quality was examined at before cryopreservation, post-equilibration and 10 min, 2 h and 4 h after freezing and thawing. CLCs at 1.5 mg/120 x 10⁶ sperm significantly improved sperm quality during sperm equilibration and cryopreservation compared to CLCs at 3 and 6 mg/120 x 10⁶ sperm and non-CLC treated sperm. It is concluded that cholesterol loading to the sperm plasma membrane by CLCs at optimal concentration decreases chilling sensitivity and also improves epididymal sperm cryopreservability.
DOI: 10.14457/cu.the.2010.733
title: Qualitative and Quantitative determinations of active principles having positive effect on mamory deficit in Longan seed extract

description: Several studies of chemicals in longan (Dimocarpus longan Lour.) seed have been suggested to have positive effect on deficit in learning and memory. In this study, the extraction methods from longan seeds found that ethyl acetate extracts showed the positive effect on learning and memory impairment after bilateral carotid arteries (2-VO) occlusion in mice. Using the fractionation of the ethyl acetate part by conventional chromatographic technique together with the screening activities, we obtained four major compounds; quercetin, gallic acid, propyl gallate and rutin. Rutin showed to be a one of the most active principle compounds at dose 100mg/kg and used to be a chemical marker for the standardized herbal extract. All the compounds were identified by physical and spectroscopic properties. Furthermore, we prepared relatively stable standardized herbal extract from longan seeds by removing the problematic phenolic portion. High performance liquid chromatography technique (HPLC technique) for determination of rutin in longan seed extract was developed and validated. This method was validated according to ICH guideline. The rutin in longan seed extract was determined using reverse phase column as stationary phase, an isocratic as mobile phase and hesperidin as internal standard. The method shows linearity range of 0.31-1.54µg/ml of rutin (r² = 0.9940).The percentage recovery (%R) was in the range of 99.30-101.98 and the relative standard determination (%RSD) was not more than 2. The limit of detection and limit of quantification of rutin were 0.13 and 0.38 µg/ml, respectively. A thin-layer chromatographic (TLC) method was developed to determine rutin by using silica gel plate GF[254] as stationary phase and butanol: glacial acetic acid (9:3) as developing solvent, hesperidin as internal standard. The detection of the TLC spot was developed by spraying with anthrone in ethanol. This method was validated according to ICH guideline. The method shows linearity range of 0.82-2.83mg/ml of rutin (r²= 0.9950) .The percentage recovery was in the range of and percentage of 98.41-100.46 .RSD was not more than 2. The limit of detection and limit of quantification of rutin were 0.21 and 0.62mg/ml, respectively.Proper validation of two analytical methods and according to ICH guidelines.