cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.1011558.v1
title: Statistical representation for the <em>T</em><sub>2 m</sub> (° C), WS<sub>10 m</sub> (m s<sup>−1</sup>), and WD<sub>10 m</sub> (deg) at the urban and rural stations

description: <b>Table 2.</b> Statistical representation for the <em>T</em><sub>2 m</sub> (° C), WS<sub>10 m</sub> (m s<sup>−1</sup>), and WD<sub>10 m</sub> (deg) at the urban and rural stations. RMSE is the root-mean square error, MAE is the mean absolute error, and MAPE is the mean absolute percentage error. <strong>Abstract</strong> Evaluation of built environment energy demand is necessary in light of global projections of urban expansion. Of particular concern are rapidly expanding urban areas in environments where consumption requirements for cooling are excessive. Here, we simulate urban air conditioning (AC) electric consumption for several extreme heat events during summertime over a semiarid metropolitan area with the Weather Research and Forecasting (WRF) model coupled to a multilayer building energy scheme. Observed total load values obtained from an electric utility company were split into two parts, one linked to meteorology (i.e., AC consumption) which was compared to WRF simulations, and another to human behavior. WRF-simulated non-dimensional AC consumption profiles compared favorably to diurnal observations in terms of both amplitude and timing. The hourly ratio of AC to total electricity consumption accounted for ~53% of diurnally averaged total electric demand, ranging from ~35% during early morning to ~65% during evening hours. Our work highlights the importance of modeling AC electricity consumption and its role for the sustainable planning of future urban energy needs. Finally, the methodology presented in this article establishes a new energy consumption-modeling framework that can be applied to any urban environment where the use of AC systems is prevalent.
DOI: 10.6084/m9.figshare.5120527.v1
title: Supplementary Material for: The Central Kink Region of Fowlicidin-2, an α-Helical Host Defense Peptide, Is Critically Involved in Bacterial Killing and Endotoxin Neutralization

description: Fowlicidins are a group of newly identified chicken cathelicidin host defense peptides. We have shown that the putatively mature fowlicidin-2 of 31 amino acid residues possesses potent antibacterial and lipopolysaccharide (LPS)- neutralizing activities, but with a noticeable toxicity to mammalian cells. As a first step in exploring the structure-activity relationships of fowlicidin-2, in this study we determined its tertiary structure by nuclear magnetic resonance spectroscopy. Unlike the majority of cathelicidins, which are composed of a predominant α-helix with a short hinge sequence near the center, fowlicidin-2 consists of 2 well-defined α-helical segments (residues 6–12 and 23–27) connected by a long extensive kink (residues 13–20) induced by proline. To further investigate the functional significance of each of these structural components, several N- and C-terminal deletion analogs of fowlicidin-2 were synthesized and analyzed for their antibacterial, cytotoxic and LPS-neutralizing activities. Our results indicated that neither the N- nor C-terminal α-helix alone is sufficient to confer any function. Rather, fowlicidin-2(1–18) and fowlicidin-2(15–31), 2 α-helical segments with inclusion of the central cationic kink region, retained substantial capacities to kill bacteria and neutralize the LPS-induced proinflammatory response, relative to the parent peptide. More desirably, these 2 peptide analogs showed substantially reduced toxicity to human erythrocytes and epithelial cells, indicative of improved potential as antibacterial and antisepsis agents. To our knowledge, fowlicidin-2 is the first α-helical cathelicidin, with the central kink region shown to be critically important in killing bacteria and neutralizing LPS.
DOI: 10.6084/m9.figshare.7393304.v2
title: Global 'water table ratio' and 'groundwater response time' raster data

description: Data supporting the publication:<br>Cuthbert et al (2019) "Global patterns and dynamics of climate-groundwater interactions" Nature Climate Change https://www.nature.com/articles/s41558-018-0386-4<br><br>See the ReadMe file uploaded with the data and the Methods section of the paper for details of the derivation of each dataset.<br>
DOI: 10.6084/m9.figshare.13387091.v1
title: Cryptocotyle lingua protein sequences predicted in curated transcriptome assembly (v1.2.2)

description: Annotated protein sequences predicted in the curated assembly (proteins: v.1.2.2) of <i>Cryptocotyle lingua</i> transcriptome. Bio-Project: PRJNA646866.<br>
DOI: 10.6084/m9.figshare.814470.v1
title: Extrapolating weak selection in evolutionary games - source code

description: Source code for the paper "Extrapolating weak selection in evolutionary games".
DOI: 10.6084/m9.figshare.19453043.v1
title: Supplementary Material for: DNA Methylation-Mediated Lowly Expressed AOX1 Promotes Cell Migration and Invasion of Prostate Cancer

description: <b><i>Introduction:</i></b> DNA methylation regulates gene transcriptional functions in the pathogenesis of malignant diseases. In prostate cancer, several tumor suppressors are known to be tumor specifically methylated. <b><i>Methods:</i></b> In this study, 450K methylation data and mRNA expression data were accessed from The Cancer Genome Atlas-Prostate Adenocarcinoma database and analyzed bioinformatically. Methylation-specific PCR was used to examine the methylation condition in AOX1 promoter. qRT-PCR was applied to measure the mRNA expression of AOX1. Western blot was employed to detect the expressions of AOX1 and the EMT associated proteins. Transwell and scratch healing assays were used to examine the invasive and migratory abilities of the prostate cancer cells respectively. <b><i>Results:</i></b> AOX1 was lowly expressed and hypermethylated in the prostate cancer tissues and cells. Also, AOX1 was downregulated at protein level in prostate cancer cells. Knocking down AOX1 could promote cell migration and invasion in the prostate cancer cells. By using a DNA methylation inhibitor, 5-AzadC was found to promote the expression of AOX1 and reverse the promoting effects of short interfering RNA against AOX1 on cell migration and invasion. <b><i>Conclusion:</i></b> This study suggested that DNA methylation and low AOX1 level might be biomarkers for prostate cancer.
DOI: 10.6084/m9.figshare.8124695.v1
title: Demographics Stroke Subjects.xlsx

description: Attached is the demographic information for acute stroke subjects
DOI: 10.6084/m9.figshare.13378946.v2
title: Elevated temperature causes differential seedling mortalities in tropical tree species

description: Amplicon sequencing data of soil fungi for the warming effect on plant-soil feedback in a tropical montane rain forest.
DOI: 10.6084/m9.figshare.26367139.v1
title: Closing the Gap: A User Study on the Real-world Usefulness of AI-powered Vulnerability Detection & Repair in the IDE

description: Work in progress. Will be updated with the camera-ready paper.
DOI: 10.6084/m9.figshare.6483779.v1
title: Public-Chemistry-Reference-Database

description: A frequently uptaded Excel Database and open source graphing tools for chemistry calculations. This table is authored and managed by Cory Andrew Hofstad, an undergraduate researcher and cumputer tutor for the Seattle Colleges.
DOI: 10.6084/m9.figshare.27161430.v1
title: Supplementary Material for: Non-alcoholic Fatty Liver Disease (NAFLD) and its association with kidney and cardiovascular outcomes in moderate to advanced chronic kidney disease

description: Introduction
Non-alcoholic fatty liver disease (NAFLD) has emerged as a potential indicator for cardio-metabolic risk. However, clinical implications of NAFLD in patients with chronic kidney disease (CKD) are still elusive. We investigated to explore the association between NAFLD and adverse clinical outcomes among patients with CKD. 
Methods
In this national population-based retrospective cohort study, we analyzed 816,857 individuals who underwent National Health Insurance Service health examinations and had an eGFR of 15–59 mL/min/1.73 m2. The main predictor was the fatty liver index (FLI), a surrogate marker for NAFLD. The primary outcome was a composite cardiovascular or kidney events, which were examined combined or separately. 
Results
During a median follow-up of 7.7 (IQR, 6.4–9.6) years, the composite outcome events occurred in 74,266 (9.1%) individuals. Among these, there were 55,525 (6.8%) cardiovascular events and 22,961 (2.8%) kidney events, respectively. Compared to FLI of &lt;30, the HRs (95% CIs) for the composite outcome were 1.16 (1.14–1.18) and 1.30 (1.26–1.33) for the FLIs of 30–59 and ≥60, respectively. The corresponding HRs for cardiovascular events were 1.21 (95% CI, 1.18–1.23) and 1.36 (95% CI, 1.31–1.40), respectively. Furthermore, FLIs of 30–59 and ≥60 were associated with an 11% (HR, 1.11; 95% CI, 1.07–1.15) and 24% (HR, 1.24; 95% CI, 1.17–1.30) increased risk of kidney events, respectively. 
Conclusions
NAFLD was associated with higher risk of adverse clinical outcomes in individuals with CKD. These findings suggest that NAFLD, as assessed by the FLI, can serve as a predictor of cardiovascular and kidney events in CKD population.
DOI: 10.6084/m9.figshare.20691913.v1
title: Processed Data

description: The dataset is the processed result from cruise data and model output. This dataset was used for the publication of the paper "Dynamic control of eastward transport of overwintering Calanus finmarchicus from the Lofoten Basin to the continental slope". Please cite this dataset when using it.
DOI: 10.6084/m9.figshare.28693397.v1
title: <b>Fluorine-Doped Micropore-</b><b>Covered</b><b> Mesoporous Carbon Nanofibers for Long-Lasting Anode-Free Sodium Metal Batteries</b>

description: <b>Original data of “Fluorine-Doped Micropore-</b><b>Covered</b><b> Mesoporous Carbon Nanofibers for Long-Lasting Anode-Free Sodium Metal Batteries”</b>
DOI: 10.6084/m9.figshare.12646319.v1
title: Supplementary Material for: Effects of Substance Misuse and Family History of Substance Use Disorder on Delay Discounting in Adolescents and Young Adults with Attention-Deficit/Hyperactivity Disorder

description: <b><i>Background:</i></b> Attention-deficit/hyperactivity disorder (ADHD) and substance use disorder (SUD) often co-occur. Both disorders are characterized by impulsive choice. However, little is known about the effects of substance misuse (SM) and family history of SUD (FH) on impulsive choice in ADHD-SUD comorbidity. Impulsive choice is also linked to callous-unemotional (CU) traits, which are suggested to play a role in ADHD-SUD comorbidity. Our aim was to examine the effects of (1) FH and (2) SM on impulsive choice, while exploring the role of CU traits. <b><i>Methods:</i></b> Impulsive choice was assessed with the delay discounting (DD) task. We compared task performance across (1) ADHD patients and controls with or without FH of SUD (ADHD FH+: <i>n</i> = 86; ADHD FH−: <i>n</i> = 63; control FH+: <i>n</i> = 49; control FH−: <i>n</i> = 72; mean age of the whole sample [<i>n</i> = 270]: 16.39, SD: 3.43) and (2) family history-matched ADHD groups with and without SM and controls (ADHD + SM: <i>n</i> = 62; ADHD-only: <i>n</i> = 62; controls: <i>n</i> = 62; mean age of the whole sample [<i>n</i> = 186]: 18.01, SD: 2.71). Effects of CU traits were explored by adding this as a covariate in all analyses. <b><i>Results:</i></b> (1) There was no main effect of FH on DD. (2) We found increased DD in ADHD + SM compared to ADHD-only and no difference between ADHD-only and controls. Finally, increased DD was associated with increased callous traits only in ADHD FH+ and control FH+. <b><i>Conclusions:</i></b> In adolescents and young adults with ADHD, high impulsive choice might only be present in those with comorbid SM and in an FH+ subgroup with high callous traits. This suggests that impulsive choice in ADHD might result from (1) effects of SM and (2) a combined effect of SUD vulnerability and high callousness. Future studies should investigate efficacy of early interventions, targeting CU traits.
DOI: 10.6084/m9.figshare.26139229.v3
title: Data used in the analysis of Personality predicts within- but not between-year variation in feather corticosterone with consequences for fitness

description: This data is used to investigate the relationship between personality, feather corticosterone and fitness traits in the black-legged kittiwake. This research forms part of the PhD thesis of Frederick C. Mckendrick at the University of Liverpool.
DOI: 10.6084/m9.figshare.26612528.v1
title: Additional file 2 of Machine learning pipeline for blood culture outcome prediction using Sysmex XN-2000 blood sample results in Western Australia

description: Additional file 2. Contains results for all models evaluated during the model training and stratified 10-fold cross validation stage.
DOI: 10.6084/m9.figshare.14113016.v1
title: Supplementary Material for: Effects of Maternal Abdominal Surgery on Fetal Brain Development in the Rabbit Model

description: <b><i>Introduction:</i></b> Anesthesia during pregnancy can impair fetal neurodevelopment, but effects of surgery remain unknown. The aim is to investigate effects of abdominal surgery on fetal brain development. Hypothesis is that surgery impairs outcome. <b><i>Methods:</i></b> Pregnant rabbits were randomized at 28 days of gestation to 2 h of general anesthesia (sevoflurane group, <i>n</i> = 6) or to anesthesia plus laparoscopic appendectomy (surgery group, <i>n</i> = 13). On postnatal day 1, neurobehavior of pups was assessed and brains harvested. Primary outcome was neuron density in the frontal cortex, and secondary outcomes included neurobehavioral assessment and other histological parameters. <b><i>Results:</i></b> Fetal survival was lower in the surgery group: 54 versus 100% litters alive at birth (<i>p</i> = 0.0442). In alive litters, pup survival until harvesting was 50 versus 69% (<i>p</i> = 0.0352). No differences were observed for primary outcome (<i>p</i> = 0.5114) for surviving pups. Neuron densities were significantly lower in the surgery group in the caudate nucleus (<i>p</i> = 0.0180), but not different in other regions. No differences were observed for secondary outcomes. Conclusions did not change after adjustment for mortality. <b><i>Conclusion:</i></b> Abdominal surgery in pregnant rabbits at a gestational age corresponding to the end of human second trimester results in limited neurohistological changes but not in neurobehavioral impairments. High intrauterine mortality limits translation to clinical scenario, where fetal mortality is close to zero.
DOI: 10.6084/m9.figshare.16652890.v3
title: Documenting Soil Archive Use in Peer-Reviewed Publications: 1915-2021

description: Peer-reviewed publications with documented use of soil archives were identified through a literature search using the USDA National Agricultural Library’s Digitop search engine, supplemented with results from Wageningen University & Research Library and Google Scholar. References in identified publications were further screened for additional publications relating to use of archived soils. Only publications in English or with English abstracts were considered. Identified publications were vetted to ensure archived soils were experimentally used in each study. For purposes of this compilation, archived soils were designated as those that had been stored for five or more years. A total of 245 publications were identified. Each publication was reviewed for key metadata, including publication year, age of oldest sample, and sample collection location. Land use associated with archived soil, along with the subject of each investigation were also recorded. Compiled metadata were transcribed into a single spreadsheet with sortable columns. An abstract for each publication was included in the spreadsheet, and when available, a digital object identifier was recorded to facilitate electronic access. Compiled information in the spreadsheet provides researchers a valuable resource for documenting use of soil archives globally.
DOI: 10.6084/m9.figshare.5128897.v1
title: Supplementary Material for: Clinical Potential of Effective Noninvasive Exclusion of <b><i>KEL1</i></b>-Positive Fetuses in <b><i>KEL1</i></b>-Negative Pregnant Women

description: <b><i>Background:</i></b> The clinical importance of assessing the fetal <i>KEL</i> genotype is to exclude ‘K'-positive fetuses (genotype <i>KEL1/KEL2</i>) in ‘K'-alloimmunized pregnant women (genotype <i>KEL2/KEL2</i>). Noninvasive assessment of the fetal <i>KEL</i> genotype is not yet available in the Czech Republic. <b><i>Objective:</i></b> The aim of this study was to assess the fetal <i>KEL1/KEL2</i> genotype from cell-free fetal DNA in the plasma of <i>KEL2/KEL2</i> pregnant women. <b><i>Methods:</i></b> The fetal genotype was assessed by minisequencing (a dilution series including control samples). A total of 138 pregnant women (between the 8th and 23rd gestational week) were tested by minisequencing. The fetal genotype was further verified by analysis of a buccal swab from the newborn. <b><i>Results:</i></b> Minisequencing proved to be a reliable method. In 2.2% (3/138) of the examined women, plasma sample testing failed; 94.8% (128/135) had the <i>KEL2/KEL2</i> genotype, and a total of 3.1% of fetuses (4/128) had the <i>KEL1/KEL2</i> genotype. Sensitivity and specificity reached 100% (p &lt; 0.0001). <b><i>Conclusion:</i></b> Minisequencing is a reliable method for the assessment of the fetal <i>KEL1</i> allele from the plasma of <i>KEL2/KEL2</i> pregnant women.
DOI: 10.17632/2w6ttxjnwh.1
title: Artificial Intelligence and the Future of Supply Chain Entrepreneurship: A Bibliometric Analysis of Business Trends and Innovations

description: Artificial Intelligence and the Future of Supply Chain Entrepreneurship: A Bibliometric Analysis of Business Trends and Innovations
DOI: 10.6084/m9.figshare.28009241.v2
title: Experimental data from the study “<b>Opposing Effects of Soil-Feedbacks on Plant Growth and Competitive Ability</b>” by Zhu et al. (2024)

description: This repository contains all the compiled data from the work "<b>Opposing Effects of Soil-Feedbacks on Plant Growth and Competitive Ability</b>" authored by Zhu et al. (2024)
DOI: 10.6084/m9.figshare.28837334.v1
title: data.zip

description: AbstractPurpose:The study aims to assess the impact of a high-fat diet on the retinal pigment epithelium of aged TgAPPswePS1 transgenic mice, focusing on the involvement of the pyroptosis pathway.Methods:Experimental study. Comparison was made between 12 18-month-old TgAPPswePS1 transgenic mice fed with high-fat diet（experimental group）and 12 TgAPPswePS1 transgenic mice of the same background and age(contral group).The fundus was examined through Micron IV. The eyes were treated with paraffin-embedded, and mode slices. HE staining was used to observe the structure of retina and take a measurement of retinal thickness. Immunofluorescence staining was conducted to detect the amyloid-beta in retinal pigment epithelium, label the expression of retinal pigment epithelium pyrolytic related proteins NLRP3, Caspase-1, GSDMD, IL-1β and IL-18, and count the number of retinal pigment epithelium. The quantitative comparison of Aβ, retinal pigment epithelium number, retinal thickness and pyrolytic related proteins NLRP3, Caspase-1, GSDMD, IL-1β and IL-18 for experimental group and control group was statistically analyzed using t test for independent samples.Results:The retinal pigment epithelium in the experimental group showed strongly positive after stained with Aβ (P&lt;0.0001). Compared with the control group, the thickness of retina in the experimental group was significantly reduced (t=5, P=0.0075), the number of retinal pigment epithelium was statistically decreased (t=4.243, P=0.0132), and the pyrolytic related proteins NLRP3, Caspase-1, GSDMD, IL-1β and IL-18 were strongly red positive in retinal pigment epithelium (P&lt;0.05). Conclusion:Our findings suggest that high-fat diet leads to Aβ accumulation in the RPE of aged TgAPPswePS1 mice, potentially causing RPE damage, and the pyroptosis pathway may play a crucial role in accelerating this process.
DOI: 10.6084/m9.figshare.5121667.v1
title: Supplementary Material for: Primate Prefrontal Cortex Evolution: Human Brains Are the Extreme of a Lateralized Ape Trend

description: The prefrontal cortex is commonly associated with cognitive capacities related to human uniqueness: purposeful actions towards higher-level goals, complex social information processing, introspection, and language. Comparative investigations of the prefrontal cortex may thus shed more light on the neural underpinnings of what makes us human. Using histological data from 19 anthropoid primate species (6 apes including humans and 13 monkeys), we investigate cross-species relative size changes along the anterior (prefrontal) and posterior (motor) axes of the cytoarchitectonically defined frontal lobe in both hemispheres. Results reveal different scaling coefficients in the left versus right prefrontal hemisphere, suggest that the primary factor underlying the evolution of primate brain architecture is left hemispheric prefrontal hyperscaling, and indicate that humans are the extreme of a left prefrontal ape specialization in relative white to grey matter volume. These results demonstrate a neural adaptive shift distinguishing the ape from the monkey radiation possibly related to a cognitive grade shift between (great) apes and other primates.
DOI: 10.6084/m9.figshare.20157005.v1
title: Supplementary Material for: Prevalence and incidence of dry eye disease in Asia: a systematic review and meta-analysis

description: Background: Dry eye disease (DED) is the most common ocular surface disease, which severely affects the quality of life. An overall estimate of the prevalence, incidence, and risk factors of DED in Asia would help in planning and implementing appropriate public health strategies. Objectives: The present study aimed to study the epidemiology of DED in Asia. Methods: A comprehensive and systematic search was performed using several databases, including PubMed, Cochrane Library, and Web of Science, in January 2021. A random-effects meta-analysis was performed on logit-transformed prevalence and incidence rates to calculate pooled prevalence and incidence estimates. Meta-regression and subgroup analyses were performed to explain the heterogeneity. Results: Among the 6,742 articles identified, 23 were included in the analysis, with a total sample size of 1,488,935 subjects. Twenty studies reported the prevalence of DED in Asia, two studies reported the incidence, and one study reported both prevalence and incidence. The estimated pooled prevalence of DED in any population in Asia was 20.1% (95% confidence interval [1]: 13.9%–28.3%), and the incidence 16.7% (95% CI: 0 %–34.9%). The prevalence rate of DED in males and females was 16.4% (95% CI: 10.0%–25.8%) and 21.7% (95% CI: 14.7%–30.8%; P &lt; 0.001), respectively. In general, the prevalence increased with age. The risk factors considered for specific populations were not significant, and the prevalence in the general population, excluding the populations considered at risk, was similar at 20.9% (95% CI: 12.8%–32.1%). Conclusions: DED is common in Asian populations and causes a significant disease burden. Its prevalence is higher in females than that in males, and it tends to increase in severity with age. Further research on additional risk factors is needed to adequately explain the epidemiology of DED in Asia.