cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.9565874
title: Additional file 9: of The genome of Ensifer alkalisoli YIC4027 provides insights for host specificity and environmental adaptations

description: Table S4. Genes involved in chemotaxis, flagellation formation, and motility of E. alkalisoli YIC4027. (XLS 272 kb)
DOI: 10.6084/m9.figshare.9565874.v1
title: Additional file 9: of The genome of Ensifer alkalisoli YIC4027 provides insights for host specificity and environmental adaptations

description: Table S4. Genes involved in chemotaxis, flagellation formation, and motility of E. alkalisoli YIC4027. (XLS 272 kb)
DOI: 10.6084/m9.figshare.13468063.v1
title: Additional file 2 of Perceived vulnerability to COVID-19 infection from event attendance: results from Louisiana, USA, two weeks preceding the national emergency declaration

description: Additional file 2. Data set used in analysis.
DOI: 10.6084/m9.figshare.13468063
title: Additional file 2 of Perceived vulnerability to COVID-19 infection from event attendance: results from Louisiana, USA, two weeks preceding the national emergency declaration

description: Additional file 2. Data set used in analysis.
DOI: 10.6084/m9.figshare.7992872.v1
title: Genome annotation for Argopecten irradians irradians

description: Genome annotation for Argopecten irradians irradians
DOI: 10.6084/m9.figshare.7992875
title: Genome annotation for Argopecten irradians concentricus

description: Genome annotation for Argopecten irradians concentricus
DOI: 10.6084/m9.figshare.17430512
title: Type IIA topoisomerase (TOP2A) triggers epithelial-mesenchymal transition and facilitates HCC progression by regulating Snail expression

description: Type IIA topoisomerase (TOP2A) is upregulated in hepatocellular carcinoma (HCC) and its expression is positively correlated with poor prognosis. However, the underlying molecular mechanism of this connection are poorly understood. Hence, the present work aimed to examine the possible mechanisms which may be useful in identifying a potential therapeutic strategy. The differential expression of TOP2A mRNA in HCC as compared with adjacent normal tissue was analyzed using the Oncomine database. The expression levels of TOP2A in HCC specimens and cell lines were assessed by Western blot and RT-qPCR. Stable cell lines were generated to knockdown or overexpress TOP2A, and then cell growth, migration, and invasion were analyzed. Furthermore, this study examined epithelial-mesenchymal transition (EMT) as well as the activation of related pathways. Additionally, the correlation between TOP2A levels and E-cadherin/Snail expression was determined in 72 HCC specimens. Higher expression levels of TOP2A were observed in HCC in Oncomine datasets, and the results were verified using 40 pairs of HCC specimens and peritumoral tissues. TOP2A expression levels were remarkably elevated in cells with great metastatic capacity. In addition, HCC cell growth, migration, and invasion were suppressed after TOP2A knockdown in MHCC97H cells (MHCC97H-shRNA-TOP2A), while these capabilities were promoted in TOP2A-overexpressing Hep3B cells (Hep3B-TOP2A). Furthermore, EMT was inhibited in MHCC97H-shRNA-TOP2A cells, but induced in Hep3B-TOP2A cells. The induction of EMT by TOP2A was shown to be mediated by Snail, as TOP2A promoted Snail expression through the p-ERK1/2/p-SMAD2 signaling pathway. TOP2A level showed a negative correlation with E-cadherin, whereas a positive correlation with that of vimentin and Snail in human HCC specimens by immunohistochemistry analyses. Kaplan–Meier survival curves revealed that TOP2A upregulation showed a positive correlation with poor prognosis patients. Taken together, TOP2A possibly enhances the metastasis of HCC by promoting EMT through the mediation of the p-ERK1/2/p-SMAD2/Snail pathway. This indicates that TOP2A maybe a potential factor to predict the prognosis of HCC.
DOI: 10.6084/m9.figshare.6945149.v2
title: Sedative drugs used for mechanically ventilated patients in intensive care units: a systematic review and network meta-analysis

description: <b>Background:</b> The effects of different sedative drugs on all-cause mortality rate, duration of ICU stay, and risk of delirium in mechanically ventilated ICU patients are unclear. This meta-analysis aimed to compare the effectiveness and safety of individual sedative drugs and drug combinations in mechanically ventilated ICU patients. <b>Materials and methods:</b> Medline, Embase, Cochrane, EBSCOhost, and ISI Web of Science databases were searched for studies that assessed sedation in ICU mechanically ventilated patients. A Bayesian random-effects model was used to combine the direct comparisons and indirect evidence. <b>Results:</b> Thirty-one randomized, controlled trials were included, which consisted of 4491 patients who received one of seven sedative drugs or a combination of drugs. There were no significant differences regarding the all-cause mortality rate. Compared to propofol, inhalation anesthetics (hazard ratio [HR] 0.121; 95% credible interval [CrI] -7.58 to 7.62), alpha agonists (HR 2.2; 95% CrI 0.776 to 5.22), propofol with benzodiazepines (HR 0.306; 95% CrI -6.97 to 7.65), ketamine with benzodiazepines (HR 6.57; 95% CrI -6.05 to 19.1) and placebo (HR 2.4; 95% CrI -5.37 to 10.3), benzodiazepines (HR 3.62; 95% CrI 0.834 to 6.2) may increase the duration of ICU stay. Compared to alpha agonists, propofol (HR 2.4; 95% CrI 0.304 to 21.1) and placebo (HR 6.12; 95% CrI 0.745 to 54.6), benzodiazepines (HR 2.59; 95% CrI 1.08 to 7.4) were associated with incremental risks of delirium. <b>Conclusion:</b> Compared to propofol, benzodiazepines may increase the duration of ICU stay. Compared to alpha agonists, benzodiazepines were associated with an increased risk of delirium.
DOI: 10.6084/m9.figshare.7992749.v1
title: Additional file 6: of Cognitive training for children and adolescents with fragile X syndrome: a randomized controlled trial of Cogmed

description: Table S5. Participant and parent characteristics by “improved”* vs. “non-improved” within the non-adaptive group. (XLSX 10 kb)
DOI: 10.6084/m9.figshare.7992875.v1
title: Genome annotation for Argopecten irradians concentricus

description: Genome annotation for Argopecten irradians concentricus
DOI: 10.6084/m9.figshare.12186369.v1
title: Additional file 3 of GWAS and co-expression network combination uncovers multigenes with close linkage effects on the oleic acid content accumulation in Brassica napus

description: Additional file 3 Table S3. Detailed analysis of two haplotype regions from chromosomes A02 and C02, including SNPs, genes and haplotype alleles related to oleic acid content variation in 50 resequencing accessions.
DOI: 10.6084/m9.figshare.7992737
title: Additional file 2: of Cognitive training for children and adolescents with fragile X syndrome: a randomized controlled trial of Cogmed

description: Table S1. Cogmed JM participant and parent characteristics by adaptive vs. non-adaptive control groups. (XLSX 10 kb)
DOI: 10.6084/m9.figshare.7992872
title: Genome annotation for Argopecten irradians irradians

description: Genome annotation for Argopecten irradians irradians
DOI: 10.6084/m9.figshare.7992737.v1
title: Additional file 2: of Cognitive training for children and adolescents with fragile X syndrome: a randomized controlled trial of Cogmed

description: Table S1. Cogmed JM participant and parent characteristics by adaptive vs. non-adaptive control groups. (XLSX 10 kb)
DOI: 10.6084/m9.figshare.7992740.v1
title: Additional file 3: of Cognitive training for children and adolescents with fragile X syndrome: a randomized controlled trial of Cogmed

description: Table S2. Cogmed RM participant and parent characteristics by adaptive vs. non-adaptive control groups. (XLSX 10 kb)
DOI: 10.6084/m9.figshare.12186351.v1
title: Additional file 1 of GWAS and co-expression network combination uncovers multigenes with close linkage effects on the oleic acid content accumulation in Brassica napus

description: Additional file 1 Table S1. Source, population structure, 50 resequencing accessions, 13 transcriptomes accessions, heritability and oleic acid phenotype information of 203 Chinese semi-winter rapeseed accessions.
DOI: 10.6084/m9.figshare.12186351
title: Additional file 1 of GWAS and co-expression network combination uncovers multigenes with close linkage effects on the oleic acid content accumulation in Brassica napus

description: Additional file 1 Table S1. Source, population structure, 50 resequencing accessions, 13 transcriptomes accessions, heritability and oleic acid phenotype information of 203 Chinese semi-winter rapeseed accessions.
DOI: 10.6084/m9.figshare.12186360
title: Additional file 2 of GWAS and co-expression network combination uncovers multigenes with close linkage effects on the oleic acid content accumulation in Brassica napus

description: Additional file 2 Table S2. SNPs and gene information in the significant association of haplotype region.
DOI: 10.6084/m9.figshare.12186360.v1
title: Additional file 2 of GWAS and co-expression network combination uncovers multigenes with close linkage effects on the oleic acid content accumulation in Brassica napus

description: Additional file 2 Table S2. SNPs and gene information in the significant association of haplotype region.
DOI: 10.6084/m9.figshare.12186369
title: Additional file 3 of GWAS and co-expression network combination uncovers multigenes with close linkage effects on the oleic acid content accumulation in Brassica napus

description: Additional file 3 Table S3. Detailed analysis of two haplotype regions from chromosomes A02 and C02, including SNPs, genes and haplotype alleles related to oleic acid content variation in 50 resequencing accessions.
DOI: 10.6084/m9.figshare.7992740
title: Additional file 3: of Cognitive training for children and adolescents with fragile X syndrome: a randomized controlled trial of Cogmed

description: Table S2. Cogmed RM participant and parent characteristics by adaptive vs. non-adaptive control groups. (XLSX 10 kb)
DOI: 10.6084/m9.figshare.7992746
title: Additional file 5: of Cognitive training for children and adolescents with fragile X syndrome: a randomized controlled trial of Cogmed

description: Table S4. Participant and parent characteristics by “improved”* vs. “non-improved” within the adaptive group. (XLSX 11 kb)
DOI: 10.6084/m9.figshare.12186378.v1
title: Additional file 4 of GWAS and co-expression network combination uncovers multigenes with close linkage effects on the oleic acid content accumulation in Brassica napus

description: Additional file 4 Table S4. Gene information of co-expression network in A02 and C02 chromosome haplotype region.
DOI: 10.6084/m9.figshare.12186387
title: Additional file 5 of GWAS and co-expression network combination uncovers multigenes with close linkage effects on the oleic acid content accumulation in Brassica napus

description: Additional file 5 Table S5. Flanking oligonucleotide sequences, chromosomal positions (best BLAST hit) and genotype calls for the 24,338unique polymorphic SNPs used for the chromosome structure and LD analyses in the diversity panel of 203 B. napus inbred lines.
DOI: 10.17028/rd.lboro.22148726
title: Supplementary information files for Synthesis and characterization of Craig-type antiaromatic species with [4n + 2] π electrons

description: Supplementary files for article Synthesis and characterization of Craig-type antiaromatic species with [4<em>n</em> + 2] π electrons
<br>
Abstract
Antiaromaticity is extended from aromaticity as a complement to describe the unsaturated cyclic molecules with antiaromatic destabilization. To prepare antiaromatic species is a particularly challenging goal in synthetic chemistry because of the thermodynamic instability of such molecules. Among that, both Hückel and Möbius antiaromatic species have been reported, whereas the Craig one has not been realized to date. Here, we report the first example of planar Craig antiaromatic species. Eight Craig antiaromatic compounds were synthesized by deprotonation-induced reduction process and were fully characterized as follows. Single-crystal X-ray crystallography showed that these complexes have planar structures composed of fused five-membered rings with clearly alternating carbon–carbon bond lengths. In addition, proton NMR (1H NMR) spectroscopy in these structures showed distinctive upfield shifts of the proton peaks to the range of antiaromatic peripheral hydrogens. Experimental spectroscopy observations, along with density-functional theory (DFT) calculations, provided evidence for the Craig antiaromaticity of these complexes. Further study experimentally and theoretically revealed that the strong exothermicity of the acid-base neutralization process was the driving force for this challenging transformation forming Craig antiaromatic species. Our findings complete a full cycle of aromatic chemistry, opening an avenue for the development of new class of antiaromatic systems.
DOI: 10.6084/m9.figshare.12186378
title: Additional file 4 of GWAS and co-expression network combination uncovers multigenes with close linkage effects on the oleic acid content accumulation in Brassica napus

description: Additional file 4 Table S4. Gene information of co-expression network in A02 and C02 chromosome haplotype region.
DOI: 10.17028/rd.lboro.22148726.v2
title: Supplementary information files for Synthesis and characterization of Craig-type antiaromatic species with [4n + 2] π electrons

description: Supplementary files for article Synthesis and characterization of Craig-type antiaromatic species with [4<em>n</em> + 2] π electrons
<br>
Abstract
Antiaromaticity is extended from aromaticity as a complement to describe the unsaturated cyclic molecules with antiaromatic destabilization. To prepare antiaromatic species is a particularly challenging goal in synthetic chemistry because of the thermodynamic instability of such molecules. Among that, both Hückel and Möbius antiaromatic species have been reported, whereas the Craig one has not been realized to date. Here, we report the first example of planar Craig antiaromatic species. Eight Craig antiaromatic compounds were synthesized by deprotonation-induced reduction process and were fully characterized as follows. Single-crystal X-ray crystallography showed that these complexes have planar structures composed of fused five-membered rings with clearly alternating carbon–carbon bond lengths. In addition, proton NMR (1H NMR) spectroscopy in these structures showed distinctive upfield shifts of the proton peaks to the range of antiaromatic peripheral hydrogens. Experimental spectroscopy observations, along with density-functional theory (DFT) calculations, provided evidence for the Craig antiaromaticity of these complexes. Further study experimentally and theoretically revealed that the strong exothermicity of the acid-base neutralization process was the driving force for this challenging transformation forming Craig antiaromatic species. Our findings complete a full cycle of aromatic chemistry, opening an avenue for the development of new class of antiaromatic systems.
DOI: 10.6084/m9.figshare.12186387.v1
title: Additional file 5 of GWAS and co-expression network combination uncovers multigenes with close linkage effects on the oleic acid content accumulation in Brassica napus

description: Additional file 5 Table S5. Flanking oligonucleotide sequences, chromosomal positions (best BLAST hit) and genotype calls for the 24,338unique polymorphic SNPs used for the chromosome structure and LD analyses in the diversity panel of 203 B. napus inbred lines.
DOI: 10.17028/rd.lboro.22148726.v1
title: Supplementary files for Synthesis and characterization of Craig-type antiaromatic species with [4n + 2] π electrons

description: Supplementary file for article Synthesis and characterization of Craig-type antiaromatic species with [4<em>n</em> + 2] π electrons
<br>
Abstract
Antiaromaticity is extended from aromaticity as a complement to describe the unsaturated cyclic molecules with antiaromatic destabilization. To prepare antiaromatic species is a particularly challenging goal in synthetic chemistry because of the thermodynamic instability of such molecules. Among that, both Hückel and Möbius antiaromatic species have been reported, whereas the Craig one has not been realized to date. Here, we report the first example of planar Craig antiaromatic species. Eight Craig antiaromatic compounds were synthesized by deprotonation-induced reduction process and were fully characterized as follows. Single-crystal X-ray crystallography showed that these complexes have planar structures composed of fused five-membered rings with clearly alternating carbon–carbon bond lengths. In addition, proton NMR (1H NMR) spectroscopy in these structures showed distinctive upfield shifts of the proton peaks to the range of antiaromatic peripheral hydrogens. Experimental spectroscopy observations, along with density-functional theory (DFT) calculations, provided evidence for the Craig antiaromaticity of these complexes. Further study experimentally and theoretically revealed that the strong exothermicity of the acid-base neutralization process was the driving force for this challenging transformation forming Craig antiaromatic species. Our findings complete a full cycle of aromatic chemistry, opening an avenue for the development of new class of antiaromatic systems.
DOI: 10.17028/rd.lboro.11663052.v1
title: Supplementary Information Files for ' Multi-material additive manufacturing of low sintering temperature Bi2Mo2O9 ceramics with Ag floating electrodes by selective laser burnout'

description: Supplementary Information Files for ' Multi-material additive manufacturing of low sintering temperature Bi2Mo2O9 ceramics with Ag floating electrodes by selective laser burnout'<br>Abstract:Additive manufacturing (AM) of co-fired low temperature ceramics offers a unique route for fabrication of novel 3D radio frequency (RF) and microwave communication components, embedded electronics and sensors. This paper describes the first-ever direct 3D printing of low temperature co-fired ceramics/floating electrode 3D structures. Slurry-based AM and selective laser burnout (SLB) were used to fabricate bulk dielectric, Bi2Mo2O9 (BMO, sintering temperature = 620–650°C, εr = 38) with silver (Ag) internal floating electrodes. A printable BMO slurry was developed and the SLB optimised to improve edge definition and burn out the binder without damaging the ceramic. The SLB increased the green strength needed for shape retention, produced crack-free parts and prevented Ag leaching into the ceramic during co-firing. The green parts were sintered after SLB in a conventional furnace at 645°C for 4 h and achieved 94.5% density, compressive strength of 4097 MPa, a relative permittivity (εr) of 33.8 and a loss tangent (tan δ) of 0.0004 (8 GHz) for BMO. The feasibility of using SLB followed by a post-printing sintering step to create BMO/Ag 3D structures was thus demonstrated.<br>
DOI: 10.17028/rd.lboro.11663052
title: Supplementary Information Files for ' Multi-material additive manufacturing of low sintering temperature Bi2Mo2O9 ceramics with Ag floating electrodes by selective laser burnout'

description: Supplementary Information Files for ' Multi-material additive manufacturing of low sintering temperature Bi2Mo2O9 ceramics with Ag floating electrodes by selective laser burnout'<br>Abstract:Additive manufacturing (AM) of co-fired low temperature ceramics offers a unique route for fabrication of novel 3D radio frequency (RF) and microwave communication components, embedded electronics and sensors. This paper describes the first-ever direct 3D printing of low temperature co-fired ceramics/floating electrode 3D structures. Slurry-based AM and selective laser burnout (SLB) were used to fabricate bulk dielectric, Bi2Mo2O9 (BMO, sintering temperature = 620–650°C, εr = 38) with silver (Ag) internal floating electrodes. A printable BMO slurry was developed and the SLB optimised to improve edge definition and burn out the binder without damaging the ceramic. The SLB increased the green strength needed for shape retention, produced crack-free parts and prevented Ag leaching into the ceramic during co-firing. The green parts were sintered after SLB in a conventional furnace at 645°C for 4 h and achieved 94.5% density, compressive strength of 4097 MPa, a relative permittivity (εr) of 33.8 and a loss tangent (tan δ) of 0.0004 (8 GHz) for BMO. The feasibility of using SLB followed by a post-printing sintering step to create BMO/Ag 3D structures was thus demonstrated.<br>
DOI: 10.6084/m9.figshare.6944465
title: Additional file 2: of A novel mutation in EYA1 in a Chinese family with Branchio-oto-renal syndrome

description: Figure S1. Electrophoregram. In minigene search, after extracting RNA from cells with Trizol, we carried out the reverse-transcription (RT) and PCR amplification experiments. The electrophoregrams, SF1a shows RNA products and SF1b shows the PCR products, imply no difference between the mutant and wild-type. (ZIP 278 kb)
DOI: 10.6084/m9.figshare.6944465.v1
title: Additional file 2: of A novel mutation in EYA1 in a Chinese family with Branchio-oto-renal syndrome

description: Figure S1. Electrophoregram. In minigene search, after extracting RNA from cells with Trizol, we carried out the reverse-transcription (RT) and PCR amplification experiments. The electrophoregrams, SF1a shows RNA products and SF1b shows the PCR products, imply no difference between the mutant and wild-type. (ZIP 278 kb)
DOI: 10.6084/m9.figshare.22148883
title: Anterior segment inflammation and its association with dry eye parameters following myopic SMILE and FS-LASIK

description: To evaluate dry eye and anterior segment inflammation after small incision lenticule extraction (SMILE) and femtosecond laser-assisted <i>in situ</i> keratomileusis (FS-LASIK), and investigate their association. This prospective and observational study included 96 eyes from 48 myopic patients. The evaluation was performed at baseline, postoperative day 1, week 1, month 1 and month 3. Outcome measures included anterior chamber flare, bulbar redness (BR), limbal redness (LR), ocular surface disease index (OSDI), tear meniscus height (TMH), the first and average noninvasive breakup time (NIBUT-1, NIBUT-a), fluorescein breakup time (FBUT), corneal fluorescein staining (CFS), and Schirmer I. Generalized estimating equations (GEEs) were applied to explore the correlation between flare and ocular surface parameters. Flare increased significantly in both groups at day 1 and week 1 and then returned to baseline at month 1. In both groups, BR decreased on day 1 and then gradually increased towards the baseline. In FS-LASIK, LR was lower than baseline at day 1 and month 3. An increase in OSDI was found in the SMILE group on day 1, and in the FS-LASIK group at day 1 to month 1. NIBUT-1 and NIBUT-a decreased significantly on day 1 in both groups. At month 3, NIBUT-a did not return to baseline in FS-LASIK. CFS increased significantly at week 1 in both groups. All parameters were comparable between SMILE and FS-LASIK except for OSDI and NIBUT-a. Time and spherical equivalent showed a correlation with flare. Both SMILE and FS-LASIK induced elevated anterior chamber flare and dry eye. However, flare might not be considered a factor determining perioperative dry eye.Key MessagesDry eye disease is common after corneal refractive surgery. Signs and symptoms of dry eye disease persist longer after FS-LASIK compared with SMILE.Both FS-LASIK and SMILE transiently disrupted blood-aqueous barrier integrity, leading to anterior segment inflammation.Anterior chamber flare might not be considered a factor explaining perioperative dry eye, other biomarkers remain for future exploration. Dry eye disease is common after corneal refractive surgery. Signs and symptoms of dry eye disease persist longer after FS-LASIK compared with SMILE. Both FS-LASIK and SMILE transiently disrupted blood-aqueous barrier integrity, leading to anterior segment inflammation. Anterior chamber flare might not be considered a factor explaining perioperative dry eye, other biomarkers remain for future exploration.