cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.28931182
title: Larvicidal potential of Knoevenagel adducts against <i>Aedes aegypti</i>: theoretical study and <i>in vitro</i> validation

description: This study investigated the larvicidal potential of Knoevenagel adducts against <i>Aedes aegypti</i> larvae to develop sustainable alternatives for controlling disease vectors like dengue. Larvicidal activity of Knoevenagel adducts (1a–l) was evaluated on fourth-stage <i>Aedes aegypti</i> larvae. Additional analyses included nitric oxide measurement, cell profiling, toxicity assessment, molecular docking, molecular dynamics simulation, and ADMET (Absorption, Distribution, Metabolism, and Toxicity) evaluation. Compounds 1c and 1g showed high larvicidal efficacy, with LC<sub>50</sub> values of 3.39 and 5.13 ppm. Hemolymph analysis revealed altered hemocyte composition, indicating an immune response, though nitric oxide levels remained unchanged. Molecular docking identified strong interactions between the <i>Aedes aegypti</i> FKBP12 enzyme (PDB: 3UQI) and Knoevenagel adducts. Compound 1g had the highest activity probability and binding affinity, while 1c showed strong interactions validated by biological assays. Molecular dynamics confirmed stable interactions of 1c and FKBP12, with both 1c and 1g displaying significant van der Waals contributions. ADMET analysis highlighted 1c as a less toxic compound, with minimal mutagenic risk, favorable pharmacokinetics, and high bioavailability. Knoevenagel adducts 1c and 1g are promising candidates for effective, selective, and environmentally friendly larvicides.
DOI: 10.6084/m9.figshare.28931182.v1
title: Larvicidal potential of Knoevenagel adducts against <i>Aedes aegypti</i>: theoretical study and <i>in vitro</i> validation

description: This study investigated the larvicidal potential of Knoevenagel adducts against <i>Aedes aegypti</i> larvae to develop sustainable alternatives for controlling disease vectors like dengue. Larvicidal activity of Knoevenagel adducts (1a–l) was evaluated on fourth-stage <i>Aedes aegypti</i> larvae. Additional analyses included nitric oxide measurement, cell profiling, toxicity assessment, molecular docking, molecular dynamics simulation, and ADMET (Absorption, Distribution, Metabolism, and Toxicity) evaluation. Compounds 1c and 1g showed high larvicidal efficacy, with LC<sub>50</sub> values of 3.39 and 5.13 ppm. Hemolymph analysis revealed altered hemocyte composition, indicating an immune response, though nitric oxide levels remained unchanged. Molecular docking identified strong interactions between the <i>Aedes aegypti</i> FKBP12 enzyme (PDB: 3UQI) and Knoevenagel adducts. Compound 1g had the highest activity probability and binding affinity, while 1c showed strong interactions validated by biological assays. Molecular dynamics confirmed stable interactions of 1c and FKBP12, with both 1c and 1g displaying significant van der Waals contributions. ADMET analysis highlighted 1c as a less toxic compound, with minimal mutagenic risk, favorable pharmacokinetics, and high bioavailability. Knoevenagel adducts 1c and 1g are promising candidates for effective, selective, and environmentally friendly larvicides.
DOI: 10.15468/dl.9etthg
title: Occurrence Download

description: A dataset containing 839 species occurrences available in GBIF matching the query:
{"type":"and","predicates":[{"type":"within","geometry":"POLYGON ((-78.73999999999999 1.97518, -78.810304 1.969612, -78.87887600000001 1.953044, -78.94402599999999 1.925885, -79.004149 1.888804, -79.05776400000001 1.842715, -79.103551 1.788753, -79.140382 1.728247, -79.16735300000001 1.662688, -79.183798 1.59369, -79.18931499999999 1.522953, -79.183769 1.452218, -79.167298 1.383227, -79.14030700000001 1.317678, -79.10346199999999 1.257185, -79.05767 1.203237, -79.00406 1.157162, -78.94395 1.120094, -78.878821 1.092945, -78.810275 1.076384, -78.73999999999999 1.070818, -78.669725 1.076384, -78.601179 1.092945, -78.53605 1.120094, -78.47593999999999 1.157162, -78.42233 1.203237, -78.376538 1.257185, -78.339693 1.317678, -78.312702 1.383227, -78.29623100000001 1.452218, -78.290685 1.522953, -78.29620199999999 1.59369, -78.312647 1.662688, -78.339618 1.728247, -78.37644899999999 1.788753, -78.422236 1.842715, -78.47585100000001 1.888804, -78.535974 1.925885, -78.601124 1.953044, -78.669696 1.969612, -78.73999999999999 1.97518))"},{"type":"equals","key":"CLASS_KEY","value":"212","matchCase":false},{"type":"greaterThanOrEquals","key":"YEAR","value":"2015","matchCase":false},{"type":"not","predicate":{"type":"in","key":"BASIS_OF_RECORD","values":["MATERIAL_CITATION","MATERIAL_SAMPLE","PRESERVED_SPECIMEN"],"matchCase":false}},{"type":"lessThanOrEquals","key":"COORDINATE_UNCERTAINTY_IN_METERS","value":"10000","matchCase":false},{"type":"equals","key":"LICENSE","value":"CC BY 4.0","matchCase":false}]}

 The dataset includes 839 records from 2 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0002352-260120142942310/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.6084/m9.figshare.31112085
title: Global, regional and national burden of orofacial clefts from 1990 to 2019: an analysis of the Global Burden of Disease Study 2019

description: Orofacial clefts are the most common congenital malformation, but the global burden and trends of orofacial clefts have not been comprehensively analysed. The aim of this study was to assess the global incidence, deaths and disability-adjusted life years (DALYs) of orofacial clefts by countries, regions, sex and sociodemographic index (SDI) from 1990 to 2019. The data on orofacial clefts were obtained from the Global Burden of Disease Study 2019. The incidence, deaths and DALYs were analysed by countries, regions, sex and SDI. Age-standardized rates and estimated annual percentage change (EAPC) were calculated to evaluate the burden and temporal trend of orofacial clefts. The association between EAPC and the human development index was assessed. Globally, the incidence, deaths and DALYs of orofacial clefts decreased from 1990 to 2019. The high SDI region showed the biggest downward trend in incidence rate from 1990 to 2019, along with the lowest age-standardized death rate and DALY rate. Some countries, such as Suriname and Zimbabwe, experienced increased death rate and DALY rate over time. The age-standardized death rate and DALY rate were negatively associated with the level of socioeconomic development. Global achievement is evident in the control of the burden of orofacial clefts. The future focus of prevention should be on low-income countries, such as South Asia and Africa, by increasing healthcare resources and improving quality.KEY MESSAGESThis is the most recent estimate of the global epidemiology of orofacial clefts, with some countries not previously assessed.The global burden of orofacial clefts showed downward trends from 1990 to 2019; however, some low-income countries are still suffering from increasing burdens.Effective measures should be taken to reduce the burden of orofacial clefts in the uncontrolled regions. This is the most recent estimate of the global epidemiology of orofacial clefts, with some countries not previously assessed. The global burden of orofacial clefts showed downward trends from 1990 to 2019; however, some low-income countries are still suffering from increasing burdens. Effective measures should be taken to reduce the burden of orofacial clefts in the uncontrolled regions.
DOI: 10.6084/m9.figshare.31112085.v1
title: Global, regional and national burden of orofacial clefts from 1990 to 2019: an analysis of the Global Burden of Disease Study 2019

description: Orofacial clefts are the most common congenital malformation, but the global burden and trends of orofacial clefts have not been comprehensively analysed. The aim of this study was to assess the global incidence, deaths and disability-adjusted life years (DALYs) of orofacial clefts by countries, regions, sex and sociodemographic index (SDI) from 1990 to 2019. The data on orofacial clefts were obtained from the Global Burden of Disease Study 2019. The incidence, deaths and DALYs were analysed by countries, regions, sex and SDI. Age-standardized rates and estimated annual percentage change (EAPC) were calculated to evaluate the burden and temporal trend of orofacial clefts. The association between EAPC and the human development index was assessed. Globally, the incidence, deaths and DALYs of orofacial clefts decreased from 1990 to 2019. The high SDI region showed the biggest downward trend in incidence rate from 1990 to 2019, along with the lowest age-standardized death rate and DALY rate. Some countries, such as Suriname and Zimbabwe, experienced increased death rate and DALY rate over time. The age-standardized death rate and DALY rate were negatively associated with the level of socioeconomic development. Global achievement is evident in the control of the burden of orofacial clefts. The future focus of prevention should be on low-income countries, such as South Asia and Africa, by increasing healthcare resources and improving quality.KEY MESSAGESThis is the most recent estimate of the global epidemiology of orofacial clefts, with some countries not previously assessed.The global burden of orofacial clefts showed downward trends from 1990 to 2019; however, some low-income countries are still suffering from increasing burdens.Effective measures should be taken to reduce the burden of orofacial clefts in the uncontrolled regions. This is the most recent estimate of the global epidemiology of orofacial clefts, with some countries not previously assessed. The global burden of orofacial clefts showed downward trends from 1990 to 2019; however, some low-income countries are still suffering from increasing burdens. Effective measures should be taken to reduce the burden of orofacial clefts in the uncontrolled regions.
DOI: 10.5281/zenodo.18287682
title: Widespread co-stress of N2 fixers by iron and phosphorus in the euphotic zone of the western North Pacific

description: The data support a manuscript currently submitted.
DOI: 10.5281/zenodo.18287683
title: Widespread co-stress of N2 fixers by iron and phosphorus in the euphotic zone of the western North Pacific

description: The data support a manuscript currently submitted.
DOI: 10.15468/dl.n5rfdd
title: Occurrence Download

description: A dataset containing 2 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Geometry POLYGON((19.13382 -2.44542,20.22216 -2.44542,20.22216 -1.74672,19.13382 -1.74672,19.13382 -2.44542))",
 "TaxonKey is one of (Profelis aurata, Caracal aurata, Profelis aurata aurata, Felis aurata)"
 ]
}

 The dataset includes 2 records from 2 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0002353-260120142942310/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.6084/m9.figshare.28024265
title: Readiness assessment for cervical cancer elimination and prevention of human papillomavirus (HPV)-related cancers in Europe – are we winning the RACE?

description: To address the cervical cancer burden globally, the World Health Organization and European Union released strategies to facilitate HPV-related cancers prevention, including cervical cancer elimination. This research assessed European country level readiness to achieve cervical cancer elimination by adhering to such strategies. Readiness for cervical cancer elimination was assessed across a range of guiding questions relevant to three defined key domains: vaccination, screening, and treatment, each with two sub-domains focusing on decision making and implementation efforts. Publicly available data sources were used to inform the scoring across domains, to tier countries into either high, moderate-high, moderate-low, and low readiness archetypes. Key parameters identified associated with the high readiness archetype were high vaccination coverage rates (&gt;70%), availability of gender neutral and catch-up vaccination, school-based vaccination availability, organized screening programs, use of HPV DNA primary screening tests, and data surveillance. Our analysis highlights significant variability in decision making and implementation of vaccination, screening, and treatment programmes across Europe. Country scores expose the need for a multifaceted approach to achieve cervical cancer elimination in Europe, encompassing solid decision making commitments, implementation of these commitments, and the ability to collect, surveil, and apply the data use accurately.
DOI: 10.6084/m9.figshare.28024265.v1
title: Readiness assessment for cervical cancer elimination and prevention of human papillomavirus (hpv)-related cancers in Europe – are we winning the RACE?

description: To address the cervical cancer burden globally, the World Health Organization and European Union released strategies to facilitate HPV-related cancers prevention, including cervical cancer elimination. This research assessed European country level readiness to achieve cervical cancer elimination by adhering to such strategies. Readiness for cervical cancer elimination was assessed across a range of guiding questions relevant to three defined key domains: vaccination, screening, and treatment, each with two sub-domains focusing on decision making and implementation efforts. Publicly available data sources were used to inform the scoring across domains, to tier countries into either high, moderate-high, moderate-low, and low readiness archetypes. Key parameters identified associated with the high readiness archetype were high vaccination coverage rates (&gt;70%), availability of gender neutral and catch-up vaccination, school-based vaccination availability, organized screening programmes, use of HPV DNA primary screening tests, and data surveillance. Our analysis highlights significant variability in decision making and implementation of vaccination, screening, and treatment programmes across Europe. Country scores expose the need for a multifaceted approach to achieve cervical cancer elimination in Europe, encompassing solid decision making commitments, implementation of these commitments, and the ability to collect, surveil, and apply the data use accurately.
DOI: 10.6084/m9.figshare.28024265.v2
title: Readiness assessment for cervical cancer elimination and prevention of human papillomavirus (HPV)-related cancers in Europe – are we winning the RACE?

description: To address the cervical cancer burden globally, the World Health Organization and European Union released strategies to facilitate HPV-related cancers prevention, including cervical cancer elimination. This research assessed European country level readiness to achieve cervical cancer elimination by adhering to such strategies. Readiness for cervical cancer elimination was assessed across a range of guiding questions relevant to three defined key domains: vaccination, screening, and treatment, each with two sub-domains focusing on decision making and implementation efforts. Publicly available data sources were used to inform the scoring across domains, to tier countries into either high, moderate-high, moderate-low, and low readiness archetypes. Key parameters identified associated with the high readiness archetype were high vaccination coverage rates (&gt;70%), availability of gender neutral and catch-up vaccination, school-based vaccination availability, organized screening programs, use of HPV DNA primary screening tests, and data surveillance. Our analysis highlights significant variability in decision making and implementation of vaccination, screening, and treatment programmes across Europe. Country scores expose the need for a multifaceted approach to achieve cervical cancer elimination in Europe, encompassing solid decision making commitments, implementation of these commitments, and the ability to collect, surveil, and apply the data use accurately.
DOI: 10.34740/kaggle/dsv/14569890
title: Global Genomic Neurofibromatosis Neoplasia
DOI: 10.6084/m9.figshare.28284551
title: Reliability of the Alberta Infant Motor Scale (AIMS) When Used via Telehealth for Neurodevelopmentally High-Risk Infants

description: To assess the reliability of the Alberta Infant Motor Scale (AIMS) when conducted <i>via</i> recorded telehealth sessions by novice and expert raters. Ten assessors (six novice, four expert) independently rated recorded telehealth assessments of 23 neurodevelopmentally high-risk infants twice. Inter- and intra-rater reliability of subscale scores, total score and percentile rankings were determined. AIMS total score inter-rater reliability was excellent across all raters (ICC = 0.92–0.96). Inter-rater-reliability across prone, supine and sitting subscale scores was excellent (ICC = 0.90–0.96) but variable for standing subscale (ICC = 0.06–0.65). Novice total score intra-rater reliability was variable (ICC = 0.45–0.94); expert reliability was excellent (ICC = 0.93–1.00). Recording to real-time telehealth assessment had excellent intra-rater reliability (ICC = 0.96). Time taken to complete the assessment was comparable to a face-to-face assessment (mean: 14.9 min). Novices paused/replayed each video more than experts (2.2 compared to 1.0 in Time 1; and 1.0 compared to 0.5 in Time 2). The AIMS assessment is reliable when undertaken <i>via</i> telehealth consultation. Time taken to complete the assessment is comparable to a face-to-face assessment. Novice inter-rater reliability was similar to experts. Training and the ability to pause/review infant motor performance may explain the accuracy achieved.
DOI: 10.6084/m9.figshare.28284551.v1
title: Reliability of the Alberta Infant Motor Scale (AIMS) When Used via Telehealth for Neurodevelopmentally High-Risk Infants

description: To assess the reliability of the Alberta Infant Motor Scale (AIMS) when conducted <i>via</i> recorded telehealth sessions by novice and expert raters. Ten assessors (six novice, four expert) independently rated recorded telehealth assessments of 23 neurodevelopmentally high-risk infants twice. Inter- and intra-rater reliability of subscale scores, total score and percentile rankings were determined. AIMS total score inter-rater reliability was excellent across all raters (ICC = 0.92–0.96). Inter-rater-reliability across prone, supine and sitting subscale scores was excellent (ICC = 0.90–0.96) but variable for standing subscale (ICC = 0.06–0.65). Novice total score intra-rater reliability was variable (ICC = 0.45–0.94); expert reliability was excellent (ICC = 0.93–1.00). Recording to real-time telehealth assessment had excellent intra-rater reliability (ICC = 0.96). Time taken to complete the assessment was comparable to a face-to-face assessment (mean: 14.9 min). Novices paused/replayed each video more than experts (2.2 compared to 1.0 in Time 1; and 1.0 compared to 0.5 in Time 2). The AIMS assessment is reliable when undertaken <i>via</i> telehealth consultation. Time taken to complete the assessment is comparable to a face-to-face assessment. Novice inter-rater reliability was similar to experts. Training and the ability to pause/review infant motor performance may explain the accuracy achieved.
DOI: 10.6084/m9.figshare.28296074
title: Equitable Access to Sports: Youth Gymnastics Coaches’ Perceptions on Promoting Inclusivity for Athletes with Autism Spectrum Disorder

description: The purpose of the study was to explore youth gymnastics coaches’ perceptions on inclusive sports participation following an educational module. The study aims to explore implications for occupational therapy professionals’ role in inclusive sports. A qualitative descriptive approach was utilized with convenience sampling occurring through online platforms. Nine participants completed an educational module on autism spectrum disorder including strategies to promote inclusion in sports and address sensory and motor issues, prior to completing a semi-structured interview. Interviews were transcribed and coded prior to the determination of themes with triangulation and member checking employed. Thematic analysis resulted in the following themes: (1) occupational engagement in sports benefits both neurodiverse and neurotypical children; (2) sociocultural and physical environments create barriers to autistic youth’s participation in sports; and (3) grace and knowledge enhance coaches’ ability to promote inclusive occupational participation in sports for autistic youth. Themes were representative of the interconnected occupational components impacting inclusive sports of which occupational therapists are poised to address. Lack of participation in sports for all children and children with disabilities is a complex system of physical, social, psychological, cultural, and environmental elements. Occupational therapists are equipped to educate youth sports providers and demonstrate leadership in advocating for inclusive sports programs to facilitate equitable sports participation, health, and wellness for children.
DOI: 10.6084/m9.figshare.28296074.v1
title: Equitable Access to Sports: Youth Gymnastics Coaches’ Perceptions on Promoting Inclusivity for Athletes with Autism Spectrum Disorder

description: The purpose of the study was to explore youth gymnastics coaches’ perceptions on inclusive sports participation following an educational module. The study aims to explore implications for occupational therapy professionals’ role in inclusive sports. A qualitative descriptive approach was utilized with convenience sampling occurring through online platforms. Nine participants completed an educational module on autism spectrum disorder including strategies to promote inclusion in sports and address sensory and motor issues, prior to completing a semi-structured interview. Interviews were transcribed and coded prior to the determination of themes with triangulation and member checking employed. Thematic analysis resulted in the following themes: (1) occupational engagement in sports benefits both neurodiverse and neurotypical children; (2) sociocultural and physical environments create barriers to autistic youth’s participation in sports; and (3) grace and knowledge enhance coaches’ ability to promote inclusive occupational participation in sports for autistic youth. Themes were representative of the interconnected occupational components impacting inclusive sports of which occupational therapists are poised to address. Lack of participation in sports for all children and children with disabilities is a complex system of physical, social, psychological, cultural, and environmental elements. Occupational therapists are equipped to educate youth sports providers and demonstrate leadership in advocating for inclusive sports programs to facilitate equitable sports participation, health, and wellness for children.