cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.21907569
title: Galvanic vestibular stimulation and its applications: a systematic review,

description: Abstract Objective: Galvanic vestibular stimulation has been evaluated in the context of vestibular rehabilitation. The objective was to identify evidence in the scientific literature about the clinical applications of galvanic vestibular stimulation. Methods: In this systematic review, the articles describing the applications of galvanic vestibular stimulation were extracted from PubMed, Web of Science, MEDLINE, Scopus, LILACS and SciELO databases. The survey was limited to articles published in English, Portuguese and Spanish. All the articles about the clinical applications of galvanic vestibular stimulation were compiled. Repeated articles in the databases, literature review articles, case reports, letters and editorials were excluded. The descriptors included: galvanic vestibular stimulation, postural balance, central nervous system diseases, vestibular diseases, spinal cord diseases and cognition. Results: The search strategy resulted in the initial selection of 994 articles; the reading of titles and abstracts was accomplished in 470 articles and the complete reading in 23 articles. Clinical applications of galvanic vestibular stimulation included Ménière’s disease, vestibular neuritis, bilateral vestibular disorders, vestibular schwannoma, Parkinson’s disease, ischemic central lesions, motor myelopathies, anxiety disorders, cognition and memory. Conclusion: Galvanic vestibular stimulation has been considered a potentially useful strategy for balance rehabilitation, since it has the effect of stimulating the central connections related to the postural balance, favoring new neuronal synapses that allow the partial or total recovery of postural imbalance.
DOI: 10.6084/m9.figshare.21907569.v1
title: Galvanic vestibular stimulation and its applications: a systematic review,

description: Abstract Objective: Galvanic vestibular stimulation has been evaluated in the context of vestibular rehabilitation. The objective was to identify evidence in the scientific literature about the clinical applications of galvanic vestibular stimulation. Methods: In this systematic review, the articles describing the applications of galvanic vestibular stimulation were extracted from PubMed, Web of Science, MEDLINE, Scopus, LILACS and SciELO databases. The survey was limited to articles published in English, Portuguese and Spanish. All the articles about the clinical applications of galvanic vestibular stimulation were compiled. Repeated articles in the databases, literature review articles, case reports, letters and editorials were excluded. The descriptors included: galvanic vestibular stimulation, postural balance, central nervous system diseases, vestibular diseases, spinal cord diseases and cognition. Results: The search strategy resulted in the initial selection of 994 articles; the reading of titles and abstracts was accomplished in 470 articles and the complete reading in 23 articles. Clinical applications of galvanic vestibular stimulation included Ménière’s disease, vestibular neuritis, bilateral vestibular disorders, vestibular schwannoma, Parkinson’s disease, ischemic central lesions, motor myelopathies, anxiety disorders, cognition and memory. Conclusion: Galvanic vestibular stimulation has been considered a potentially useful strategy for balance rehabilitation, since it has the effect of stimulating the central connections related to the postural balance, favoring new neuronal synapses that allow the partial or total recovery of postural imbalance.
DOI: 10.6084/m9.figshare.21907572
title: Changes in activities of antioxidant enzymes in radish (Raphanus sativus) seedlings in response to allelopathic effect of safflower (Carthamus tinctorius)

description: Abstract ROS (Reactive Oxygen Species) production is a usual plant reaction to environmental stresses such as allelopathy. Plants possess antioxidant enzymes to scavenge cells and resist against the ROS. This study was conducted to evaluate changes in antioxidant enzymes (CAT, GPX, APX) in radish seedlings in response to allelopathic effect of safflower root and shoot residues grown under normal irrigation and drought stress. Safflower allelopathic effect led to an increase in antioxidant enzymes activities. GPX activity increased more than CAT and APX. Radish seedlings exposed to safflower residue grown under drought stress showed more antioxidant enzymes activities. Root residues enhanced the activities of antioxidant enzymes greater than shoot. Seedlings exposed to root residues grown under drought stress had the highest level of antioxidant enzymes activities.
DOI: 10.6084/m9.figshare.21907572.v1
title: Changes in activities of antioxidant enzymes in radish (Raphanus sativus) seedlings in response to allelopathic effect of safflower (Carthamus tinctorius)

description: Abstract ROS (Reactive Oxygen Species) production is a usual plant reaction to environmental stresses such as allelopathy. Plants possess antioxidant enzymes to scavenge cells and resist against the ROS. This study was conducted to evaluate changes in antioxidant enzymes (CAT, GPX, APX) in radish seedlings in response to allelopathic effect of safflower root and shoot residues grown under normal irrigation and drought stress. Safflower allelopathic effect led to an increase in antioxidant enzymes activities. GPX activity increased more than CAT and APX. Radish seedlings exposed to safflower residue grown under drought stress showed more antioxidant enzymes activities. Root residues enhanced the activities of antioxidant enzymes greater than shoot. Seedlings exposed to root residues grown under drought stress had the highest level of antioxidant enzymes activities.
DOI: 10.6084/m9.figshare.21907575
title: Proportion and factors associated with Apgar less than 7 in the 5th minute of life: from 1999 to 2019, what has changed?

description: Abstract Although variation between observers in the assessment of the Apgar score, it remains a useful indicator of the general conditions of the newborn. This is a cross-sectional study based on population of live births in Brazil in 1999 and biennium 2018-2019. All declarations of live births (DNV) obtained from the Live Births System database were accessed. Frequencies were compared between groups using Pearson’s chi-square test and multivariate logistic regression analysis was performed. A statistical significance level of 0.05 was considered. We included 9.050.521 DNVs in our research. We found that 2,1% of newborns had 5th minute Apgar &lt; 7 in 1999 compared with 0,9% in 2018-2019. Multivariate analysis shows that twins and teenage pregnancy are no longer risk factors. Among risk factors, we observed an increase in prematurity, low birth weight and congenital anomalies. An improvement in maternal markers was observed, especially increase in the number of prenatal consultations and schooling. Such findings demonstrate the importance access and adequate prenatal care and improved socioeconomic conditions as effective strategy to reduce neonatal morbidity and mortality.
DOI: 10.6084/m9.figshare.21907575.v1
title: Proportion and factors associated with Apgar less than 7 in the 5th minute of life: from 1999 to 2019, what has changed?

description: Abstract Although variation between observers in the assessment of the Apgar score, it remains a useful indicator of the general conditions of the newborn. This is a cross-sectional study based on population of live births in Brazil in 1999 and biennium 2018-2019. All declarations of live births (DNV) obtained from the Live Births System database were accessed. Frequencies were compared between groups using Pearson’s chi-square test and multivariate logistic regression analysis was performed. A statistical significance level of 0.05 was considered. We included 9.050.521 DNVs in our research. We found that 2,1% of newborns had 5th minute Apgar &lt; 7 in 1999 compared with 0,9% in 2018-2019. Multivariate analysis shows that twins and teenage pregnancy are no longer risk factors. Among risk factors, we observed an increase in prematurity, low birth weight and congenital anomalies. An improvement in maternal markers was observed, especially increase in the number of prenatal consultations and schooling. Such findings demonstrate the importance access and adequate prenatal care and improved socioeconomic conditions as effective strategy to reduce neonatal morbidity and mortality.
DOI: 10.6084/m9.figshare.21907576
title: Deaths of doctors and nursing staff by COVID-19 in Brazil: a sociological approach

description: Abstract The article addresses the most basic nuances and key issues involved in the high mortality of doctors, nurses, technicians and nursing assistants, as a result of COVID-19 in Brazil. This is a study based on data from the Federal Councils of Medicine and Nursing (CFM and Cofen, respectively) and the study on the death inventory of the Oswaldo Cruz Foundation (Fiocruz), and aims to understand and analyze this reality in the light of the sociology of professions. The work makes a relevant and unprecedented contribution to the understanding of the past, present and future of working class segments that work at the bedside, on the front line, providing direct care to patients.
DOI: 10.6084/m9.figshare.21907576.v1
title: Deaths of doctors and nursing staff by COVID-19 in Brazil: a sociological approach

description: Abstract The article addresses the most basic nuances and key issues involved in the high mortality of doctors, nurses, technicians and nursing assistants, as a result of COVID-19 in Brazil. This is a study based on data from the Federal Councils of Medicine and Nursing (CFM and Cofen, respectively) and the study on the death inventory of the Oswaldo Cruz Foundation (Fiocruz), and aims to understand and analyze this reality in the light of the sociology of professions. The work makes a relevant and unprecedented contribution to the understanding of the past, present and future of working class segments that work at the bedside, on the front line, providing direct care to patients.
DOI: 10.6084/m9.figshare.21907582
title: The effect of increase in blood glucose level on hearing loss

description: Abstract Objective: Previous studies have shown that hearing function is also vulnerable to the effects of diabetes mellitus which can be shown by brainstem auditory evoked potential and distortion product otoacoustic emission recordings. This study aimed to investigate the changes of brainstem auditory evoked potential and distortion product otoacoustic emission in hyperglycemia and whether there is a relationship between reactive oxygen substances production and hearing deterioration in the rat model. Methods: 25 streptozotocin induced diabetic rats were divided into three groups: control, high blood glucose, and diabetes mellitus. Brainstem auditory evoked potential and distortion product otoacoustic emission were recorded, and thiobarbituric acid reactive substances levels were measured in the brainstem tissue. Results: At 8 kHz, the latencies of I, II, III, IV, and V brainstem auditory evoked potential waves in high blood glucose and diabetes mellitus groups were elongated, at 16 kHz, only these wave latencies of the diabetes mellitus group were prolonged compared with the control group. A significant decrease was also found in distortion product otoacoustic emission amplitudes at 4, 6, 8, and 10 kHz in the high blood glucose and diabetes mellitus groups compared to the control group. There was a significant increase in thiobarbituric acid reactive substances values due to the increase in blood glucose levels in the high blood glucose and diabetes mellitus groups compared to the control group. Conclusion: These results suggested that high blood glucose levels may cause hearing impairment not only in the diabetic state but also in the period of hyperglycemia before the onset of manifest diabetes mellitus and reactive oxygen substances may play an important role in the pathophysiology of diabetes mellitus. We suggest that regulating high glucose levels even before the onset of manifest diabetes mellitus may prevent hazardous effects on hearing function. Level of evidence: Level 3.
DOI: 10.6084/m9.figshare.21907582.v1
title: The effect of increase in blood glucose level on hearing loss

description: Abstract Objective: Previous studies have shown that hearing function is also vulnerable to the effects of diabetes mellitus which can be shown by brainstem auditory evoked potential and distortion product otoacoustic emission recordings. This study aimed to investigate the changes of brainstem auditory evoked potential and distortion product otoacoustic emission in hyperglycemia and whether there is a relationship between reactive oxygen substances production and hearing deterioration in the rat model. Methods: 25 streptozotocin induced diabetic rats were divided into three groups: control, high blood glucose, and diabetes mellitus. Brainstem auditory evoked potential and distortion product otoacoustic emission were recorded, and thiobarbituric acid reactive substances levels were measured in the brainstem tissue. Results: At 8 kHz, the latencies of I, II, III, IV, and V brainstem auditory evoked potential waves in high blood glucose and diabetes mellitus groups were elongated, at 16 kHz, only these wave latencies of the diabetes mellitus group were prolonged compared with the control group. A significant decrease was also found in distortion product otoacoustic emission amplitudes at 4, 6, 8, and 10 kHz in the high blood glucose and diabetes mellitus groups compared to the control group. There was a significant increase in thiobarbituric acid reactive substances values due to the increase in blood glucose levels in the high blood glucose and diabetes mellitus groups compared to the control group. Conclusion: These results suggested that high blood glucose levels may cause hearing impairment not only in the diabetic state but also in the period of hyperglycemia before the onset of manifest diabetes mellitus and reactive oxygen substances may play an important role in the pathophysiology of diabetes mellitus. We suggest that regulating high glucose levels even before the onset of manifest diabetes mellitus may prevent hazardous effects on hearing function. Level of evidence: Level 3.
DOI: 10.6084/m9.figshare.21907584.v1
title: Decreased body-fat accumulation and increased vasorelaxation to glyceryl trinitrate in middle-aged male rats following six-weeks consumption of coconut milk protein

description: Abstract We investigated whether coconut milk protein (CMP) contributes to the beneficial effects of coconut milk consumption on cardiovascular health markers previously found in middle-aged rats. CMP was isolated and precipitated from dried fresh coconut milk, then gavaged (1 g/kg) to middle-aged male rats for six weeks; control rats received distilled water. Compared to controls, CMP caused decreased body fat and lipid accumulation in liver cells and the platelet count. CMP did not affect basal blood pressure or heart rate in anesthetized rats. Vascular responsiveness to phenylephrine, DL-propargylglycine (PAG), acetylcholine or sodium nitroprusside was unaffected, but vasorelaxation to glyceryl trinitrate (GTN) increased. Effects of ODQ on vasorelaxation to GTN were similar in both groups. Expression of blood vessel eNOS, CSE and sGC was normal. The cyclic guanosine monophosphate (cGMP) level of CMP-treated rats was normal but addition of GTN increased cGMP and NO concentration more in CMP-treated rats than in controls, an effect unaltered by addition of diadzin. Taken together, CMP appears partially responsible for the improvement in cardiovascular health markers caused by coconut milk in middle-aged male rats.
DOI: 10.6084/m9.figshare.21907584
title: Decreased body-fat accumulation and increased vasorelaxation to glyceryl trinitrate in middle-aged male rats following six-weeks consumption of coconut milk protein

description: Abstract We investigated whether coconut milk protein (CMP) contributes to the beneficial effects of coconut milk consumption on cardiovascular health markers previously found in middle-aged rats. CMP was isolated and precipitated from dried fresh coconut milk, then gavaged (1 g/kg) to middle-aged male rats for six weeks; control rats received distilled water. Compared to controls, CMP caused decreased body fat and lipid accumulation in liver cells and the platelet count. CMP did not affect basal blood pressure or heart rate in anesthetized rats. Vascular responsiveness to phenylephrine, DL-propargylglycine (PAG), acetylcholine or sodium nitroprusside was unaffected, but vasorelaxation to glyceryl trinitrate (GTN) increased. Effects of ODQ on vasorelaxation to GTN were similar in both groups. Expression of blood vessel eNOS, CSE and sGC was normal. The cyclic guanosine monophosphate (cGMP) level of CMP-treated rats was normal but addition of GTN increased cGMP and NO concentration more in CMP-treated rats than in controls, an effect unaltered by addition of diadzin. Taken together, CMP appears partially responsible for the improvement in cardiovascular health markers caused by coconut milk in middle-aged male rats.
DOI: 10.6084/m9.figshare.21907588
title: Information and entrepreneurship: a case study with Brazilian and Canadian academic

description: ABSTRACT This article brings information and academic entrepreneurship as central themes, researched in the light of the Biology of Knowing. It aims to identify where is located the information that supports the entrepreneurial mindset of academics at the Federal University of Minas Gerais (UFMG), in Brazil, and Western University, in Canada, characterizing the family and academic environments to which they are exposed. Based on two case studies, the research has a qualitative and descriptive characteristic, and data were collected from structured interviews that considered the life stories of seven UFMG professors and seven Western University alumni. The primary evidence is that the determinant information of the entrepreneurial mentality was built from two factors in interaction: the biological characteristics of the research subjects, open to the entrepreneurial initiative, and the primary influence of the family environment, whether through life experiences or memories of words and attitudes of parents and relatives. The academic environment was also relevant, being able to encourage or act as a barrier to entrepreneurship. The relevance of entrepreneurial education is highlighted, fundamental for the formation of the knowing and decision-making subject, in constant interaction with other subjects and environments.
DOI: 10.6084/m9.figshare.21907588.v1
title: Information and entrepreneurship: a case study with Brazilian and Canadian academic

description: ABSTRACT This article brings information and academic entrepreneurship as central themes, researched in the light of the Biology of Knowing. It aims to identify where is located the information that supports the entrepreneurial mindset of academics at the Federal University of Minas Gerais (UFMG), in Brazil, and Western University, in Canada, characterizing the family and academic environments to which they are exposed. Based on two case studies, the research has a qualitative and descriptive characteristic, and data were collected from structured interviews that considered the life stories of seven UFMG professors and seven Western University alumni. The primary evidence is that the determinant information of the entrepreneurial mentality was built from two factors in interaction: the biological characteristics of the research subjects, open to the entrepreneurial initiative, and the primary influence of the family environment, whether through life experiences or memories of words and attitudes of parents and relatives. The academic environment was also relevant, being able to encourage or act as a barrier to entrepreneurship. The relevance of entrepreneurial education is highlighted, fundamental for the formation of the knowing and decision-making subject, in constant interaction with other subjects and environments.
DOI: 10.6084/m9.figshare.21907591
title: Cashmirins A and B, new antifungal and urease inhibitory prenylated coumarins from Sorbus cashmiriana

description: Abstract Cashmirins A (1) and B (2), new prenylated coumarins, have been isolated from the EtOAc- soluble fraction of the whole plant of Sorbus cashmiriana Hedlung, Monog. along with seselin (3), scopoletin (4), 3-hydroxyxanthyletin (5) and luteolin (6), reported for the first time from this species. Their structures were elucidated by spectroscopic techniques including MS, 1D and 2D NMR spectroscopy. Both new compounds 1 and 2 were investigated for biological activities and showed significant antifungal and urease inhibitory activities. Compounds 1 and 2 exhibited significant activity against Aspergillus flavus, Macrophomina phaseolina, Trichophyton simii, Trichophyton schoenleinii, and Pseudallescheria boydri. Both compounds also exhibited significant inhibitory activity against Jack bean urease with IC50 values of 28.2±0.12 µM and 30.3±0.18 µM, respectively compared to thiourea used as positive control.
DOI: 10.6084/m9.figshare.21907591.v1
title: Cashmirins A and B, new antifungal and urease inhibitory prenylated coumarins from Sorbus cashmiriana

description: Abstract Cashmirins A (1) and B (2), new prenylated coumarins, have been isolated from the EtOAc- soluble fraction of the whole plant of Sorbus cashmiriana Hedlung, Monog. along with seselin (3), scopoletin (4), 3-hydroxyxanthyletin (5) and luteolin (6), reported for the first time from this species. Their structures were elucidated by spectroscopic techniques including MS, 1D and 2D NMR spectroscopy. Both new compounds 1 and 2 were investigated for biological activities and showed significant antifungal and urease inhibitory activities. Compounds 1 and 2 exhibited significant activity against Aspergillus flavus, Macrophomina phaseolina, Trichophyton simii, Trichophyton schoenleinii, and Pseudallescheria boydri. Both compounds also exhibited significant inhibitory activity against Jack bean urease with IC50 values of 28.2±0.12 µM and 30.3±0.18 µM, respectively compared to thiourea used as positive control.
DOI: 10.6084/m9.figshare.21907593
title: Institutional support by Higher Education Institutions to Editors of Scientific Journals

description: ABSTRACT Public higher education institutions are responsible for editing most scientific journals in Brazil. Professors of graduate programs voluntarily manage the editorial flow. This article discusses the institutional contributions in financial, human, physical and technological terms received by editors, necessary to comply with good editorial practices. It is an applied research, with exploratory and descriptive purposes, carried out with 95 editors linked to the Brazilian Association of Scientific Editors. The results obtained point out the existing gaps in the institutional support received, mainly regarding the establishment of technical criteria for the selection, permanence and renewal of the editor; to digital preservation; the insufficiency of financial resources for the self-sustainability of the periodicals and even in relation to the formalization of the periodicals with the publishing institutions. The conclusions show that part of the editors' needs are not met due to a question of double responsibility: on the one hand, the editors, who start this activity without training or qualification in the editorial area, which leaves them vulnerable to the very poor weather of the function; on the other hand, the institutions themselves that because they do not have a specific framework for the function, suffer from the same problems of not knowing the institutional support necessary for scientific publishing.