cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.25392/leicester.data.19874230.v1
title: Investigating the role of Histone Deacetylase 1 in embryonic stem cells and early embryonic development - Appendices

description: Appendices for thesis titled: Investigating the role of Histone Deacetylase 1 in embryonic stem cells and early embryonic development. <br> Content: I. Full Proximity Dependent Biotinylation results II RNA-seq Quality Control and Differentially Expressed Genes III. Histone mass spectrometry data <br>
DOI: 10.6084/m9.figshare.19898570
title: The Impact of Education on All-cause Mortality Following St-Segment Elevation Myocardial Infarction (STEMI): Results from the Brazilian Heart Study

description: Abstract Background Low schooling has been considered an important modifiable risk factor for the development of cardiovascular disease for a long time. Despite that, whether this factor impacts the outcomes following ST-segment elevation myocardial infarction (STEMI) is poorly understood. Objective To investigate whether schooling stands as an independent risk factor for mortality in STEMI patients. Methods STEMI-diagnosed patients were consecutively enrolled from a prospective cohort (Brasilia Heart Study) and categorized according to years of study quartiles (0-3, 4-5, 6-10 and &gt;10 years). Groups were compared by student’s t test for continuous variables and qui-square for categorical. Incidence of all-cause mortality was compared with Kaplan-Meyer with Cox regression adjusted by age, gender, and GRACE score. Values of p &lt; 0.05 were considered significant. SPSS21.0 was used for all analysis. Results The mean schooling duration was 6.63±4.94 years. During the follow-up period (mean: 21 months; up to 6.8 years), 83 patients died (cumulative mortality of 15%). Mortality rate was higher among the lowest quartile compared to those in the highest quartile [18.5 vs 6.8%; HR 2.725 (95% CI: 1.27-5.83; p=0.01)]. In multivariate analysis, low schooling has lost statistical significance for all-cause mortality after adjustment for age and gender, with HR of 1.305 (95% CI: 0.538-3.16; p=0.556), and after adjustment by GRACE score with an HR of 1.767 (95% CI: .797-3.91; p=0.161). Conclusion Low schooling was not an independent risk factor for mortality in STEMI patients.
DOI: 10.6084/m9.figshare.19898570.v1
title: The Impact of Education on All-cause Mortality Following St-Segment Elevation Myocardial Infarction (STEMI): Results from the Brazilian Heart Study

description: Abstract Background Low schooling has been considered an important modifiable risk factor for the development of cardiovascular disease for a long time. Despite that, whether this factor impacts the outcomes following ST-segment elevation myocardial infarction (STEMI) is poorly understood. Objective To investigate whether schooling stands as an independent risk factor for mortality in STEMI patients. Methods STEMI-diagnosed patients were consecutively enrolled from a prospective cohort (Brasilia Heart Study) and categorized according to years of study quartiles (0-3, 4-5, 6-10 and &gt;10 years). Groups were compared by student’s t test for continuous variables and qui-square for categorical. Incidence of all-cause mortality was compared with Kaplan-Meyer with Cox regression adjusted by age, gender, and GRACE score. Values of p &lt; 0.05 were considered significant. SPSS21.0 was used for all analysis. Results The mean schooling duration was 6.63±4.94 years. During the follow-up period (mean: 21 months; up to 6.8 years), 83 patients died (cumulative mortality of 15%). Mortality rate was higher among the lowest quartile compared to those in the highest quartile [18.5 vs 6.8%; HR 2.725 (95% CI: 1.27-5.83; p=0.01)]. In multivariate analysis, low schooling has lost statistical significance for all-cause mortality after adjustment for age and gender, with HR of 1.305 (95% CI: 0.538-3.16; p=0.556), and after adjustment by GRACE score with an HR of 1.767 (95% CI: .797-3.91; p=0.161). Conclusion Low schooling was not an independent risk factor for mortality in STEMI patients.
DOI: 10.6084/m9.figshare.19900881
title: The Teaching Dream: Fantastic Loom

description: Abstract The text begins with an oneiric procedure. It shares questions on the conceptual and analytical category about the Teaching dream. Previously, in the aphoristic way, in a sequence of successive frames, places the common background of studies already developed, in its tropological or curiological field: there where concepts, senses, propositions and theses — about Teaching, Archive, Curriculum, Didactics, Aula, EIS AICE, Translation, Teacher, Poetry — plunge into the oneiric discourse and curl up in it like tendrils. It presents dream points, in its historicity, knowledge areas, problematizations and triggers, on the part of educational research, in addition to its relations with writreading and death. Thus, it configures the current stage of oneirocritic research; which, in a network, harvests meteors and eats desert dust. At the same time that it points out the prudence of, at present, recording the following collective epitaph: It is sinister how we execute cruelties against our own teaching.
DOI: 10.6084/m9.figshare.19900881.v1
title: The Teaching Dream: Fantastic Loom

description: Abstract The text begins with an oneiric procedure. It shares questions on the conceptual and analytical category about the Teaching dream. Previously, in the aphoristic way, in a sequence of successive frames, places the common background of studies already developed, in its tropological or curiological field: there where concepts, senses, propositions and theses — about Teaching, Archive, Curriculum, Didactics, Aula, EIS AICE, Translation, Teacher, Poetry — plunge into the oneiric discourse and curl up in it like tendrils. It presents dream points, in its historicity, knowledge areas, problematizations and triggers, on the part of educational research, in addition to its relations with writreading and death. Thus, it configures the current stage of oneirocritic research; which, in a network, harvests meteors and eats desert dust. At the same time that it points out the prudence of, at present, recording the following collective epitaph: It is sinister how we execute cruelties against our own teaching.
DOI: 10.6084/m9.figshare.19900905
title: Harvesting of Chlorella sorokiniana BR001 cultivated in a low-nitrogen medium using different techniques

description: ABSTRACT: The harvesting process is a current challenge for the commercial production of microalgae because the biomass is diluted in the culture medium. Several methods have been proposed to harvest microalgae cells, but there is not a consensus about the optimum method for such application. Herein, the methods based on sedimentation, flocculation, and centrifugation were evaluated on the recovery of Chlorella sorokiniana BR001 cultivated in a low-nitrogen medium. C. sorokiniana BR001 was cultivated using a low-nitrogen medium to trigger the accumulation of neutral lipids and neutral carbohydrates. The biomass of C. sorokiniana BR001 cultivated in a low-nitrogen medium showed a total lipid content of 1.9 times higher (23.8 ± 4.5%) when compared to the biomass produced in a high-nitrogen medium (12.3 ± 1.2%). In addition, the biomass of the BR001 strain cultivated in a low-nitrogen medium showed a high content of neutral carbohydrates (52.1 ± 1.5%). The natural sedimentation-based process was evaluated using a sedimentation column, and it was concluded that C. sorokiniana BR001 is a non-flocculent strain. Therefore, it was evaluated the effect of different concentrations of ferric sulfate (0.005 to 1 g L-1) or aluminum sulfate (0.025 to 0.83 g L-1) on the flocculation process of C. sorokiniana BR001, but high doses of flocculant agents were required for an efficient harvest of biomass. It was evaluated the centrifugation at low speed (300 to 3,000 g) as well, and it was possible to conclude that this process was the most adequate to harvest the non-flocculent strain C. sorokiniana BR001.
DOI: 10.6084/m9.figshare.19900905.v1
title: Harvesting of Chlorella sorokiniana BR001 cultivated in a low-nitrogen medium using different techniques

description: ABSTRACT: The harvesting process is a current challenge for the commercial production of microalgae because the biomass is diluted in the culture medium. Several methods have been proposed to harvest microalgae cells, but there is not a consensus about the optimum method for such application. Herein, the methods based on sedimentation, flocculation, and centrifugation were evaluated on the recovery of Chlorella sorokiniana BR001 cultivated in a low-nitrogen medium. C. sorokiniana BR001 was cultivated using a low-nitrogen medium to trigger the accumulation of neutral lipids and neutral carbohydrates. The biomass of C. sorokiniana BR001 cultivated in a low-nitrogen medium showed a total lipid content of 1.9 times higher (23.8 ± 4.5%) when compared to the biomass produced in a high-nitrogen medium (12.3 ± 1.2%). In addition, the biomass of the BR001 strain cultivated in a low-nitrogen medium showed a high content of neutral carbohydrates (52.1 ± 1.5%). The natural sedimentation-based process was evaluated using a sedimentation column, and it was concluded that C. sorokiniana BR001 is a non-flocculent strain. Therefore, it was evaluated the effect of different concentrations of ferric sulfate (0.005 to 1 g L-1) or aluminum sulfate (0.025 to 0.83 g L-1) on the flocculation process of C. sorokiniana BR001, but high doses of flocculant agents were required for an efficient harvest of biomass. It was evaluated the centrifugation at low speed (300 to 3,000 g) as well, and it was possible to conclude that this process was the most adequate to harvest the non-flocculent strain C. sorokiniana BR001.
DOI: 10.6084/m9.figshare.19900941
title: Reconnection Sites in Redo Ablation after Cryoballoon Pulmonary Vein Isolation in Patients with Paroxysmal Atrial Fibrillation

description: Abstract Background In paroxysmal atrial fibrillation (PAF), pulmonary vein isolation using cryoballoon (CB-PVI) has similar efficacy as radiofrequency ablation (RF-PVI) has. In redo ablation procedures following RF-PVI, PV reconnection is high, whereas in patients with redo following CB-PVI, information is scarce. Objective To determine the sites of PV reconnection in patients who underwent redo ablation after initial CB-PVI. Methods Patients who underwent an AF redo procedure, following an initial CB-PVI for PAF were included. LA electroanatomic mapping was used. A reconnection site was defined as the presence of a voltage of 0.3mV or greater in the PV and unidirectional or bidirectional conduction in the PV during sinus rhythm. Reconnections sites were identified using a clock-face view description and were ablated with radiofrequency afterwards. Results Out of the 165 patients who underwent initial PVI, 27 required redo ablations, of which 18 (66.6%) were males, with a mean age of 55+12.3 years. The time of recurrence was 8.9+6.4 months. PV reconnection was found in 21 (77.8%) patients. There was a total of 132 conduction gaps, six per patient, 3.6 per PV. A significant number of gaps were in the anterosuperior region of the left superior PV (LSPV), and in the septal and inferior regions of the right superior PV (RSPV). Conclusions The upper PVs had the most reconnection sites, mostly at the anterior region of the LSPV and the septal region of the RSPV. The reason behind this may be due to greater atrial wall thickness, and difficulty in achieving adequate cryoballoon contact.
DOI: 10.6084/m9.figshare.19900941.v1
title: Reconnection Sites in Redo Ablation after Cryoballoon Pulmonary Vein Isolation in Patients with Paroxysmal Atrial Fibrillation

description: Abstract Background In paroxysmal atrial fibrillation (PAF), pulmonary vein isolation using cryoballoon (CB-PVI) has similar efficacy as radiofrequency ablation (RF-PVI) has. In redo ablation procedures following RF-PVI, PV reconnection is high, whereas in patients with redo following CB-PVI, information is scarce. Objective To determine the sites of PV reconnection in patients who underwent redo ablation after initial CB-PVI. Methods Patients who underwent an AF redo procedure, following an initial CB-PVI for PAF were included. LA electroanatomic mapping was used. A reconnection site was defined as the presence of a voltage of 0.3mV or greater in the PV and unidirectional or bidirectional conduction in the PV during sinus rhythm. Reconnections sites were identified using a clock-face view description and were ablated with radiofrequency afterwards. Results Out of the 165 patients who underwent initial PVI, 27 required redo ablations, of which 18 (66.6%) were males, with a mean age of 55+12.3 years. The time of recurrence was 8.9+6.4 months. PV reconnection was found in 21 (77.8%) patients. There was a total of 132 conduction gaps, six per patient, 3.6 per PV. A significant number of gaps were in the anterosuperior region of the left superior PV (LSPV), and in the septal and inferior regions of the right superior PV (RSPV). Conclusions The upper PVs had the most reconnection sites, mostly at the anterior region of the LSPV and the septal region of the RSPV. The reason behind this may be due to greater atrial wall thickness, and difficulty in achieving adequate cryoballoon contact.
DOI: 10.6084/m9.figshare.19900951
title: Polypharmacy simulation and pharmacotherapy perceptions among students from a university in Ceará: a pilot study

description: Abstract: Introduction: Given the high prevalence of polypharmacy patients, it is paramount that they be handled with an effective therapeutic alliance and with safe and feasible treatments. Empathy towards the patient is essential, and the lack of prescriber experience may hamper such bond. Objectives: This study simulates a polypharmacy regimen among medical students, aiming to promote reflections about the daily challenges faced by patients. Methods: It is a prospective study in a single, non-blind group. The participants were medical students and residents from our institution, all of whom followed a 7-day placebo prescription. They answered questionnaires on their perceptions of medication adherence and concordance before and after the simulation. Results: twenty-eight volunteers participated, 27 of which (96.4%) forgot to take at least one pill during the experiment. Among the lower undergraduates, 28.57% interrupted at least one medication. As for the higher undergraduates and residents, this happened with 71.43% of them. There were more adherence failures than predicted by the participants themselves. In realistic dosages, levothyroxine, angiotensin-converting enzyme inhibitors and metformin were the drugs reported to be the most difficult. 96% of the volunteers strongly agreed that doctor and patient’s agreement regarding the treatment correlates with good adherence. Conclusion: Understanding the factors that affect adherence and how to handle them is essential for a doctor, as well as a good bond with the patient. The teaching of these abilities is very necessary. Further studies are needed to reach more undergraduate students and to highlight the relevance of simulations in the medical education setting.
DOI: 10.6084/m9.figshare.19900951.v1
title: Polypharmacy simulation and pharmacotherapy perceptions among students from a university in Ceará: a pilot study

description: Abstract: Introduction: Given the high prevalence of polypharmacy patients, it is paramount that they be handled with an effective therapeutic alliance and with safe and feasible treatments. Empathy towards the patient is essential, and the lack of prescriber experience may hamper such bond. Objectives: This study simulates a polypharmacy regimen among medical students, aiming to promote reflections about the daily challenges faced by patients. Methods: It is a prospective study in a single, non-blind group. The participants were medical students and residents from our institution, all of whom followed a 7-day placebo prescription. They answered questionnaires on their perceptions of medication adherence and concordance before and after the simulation. Results: twenty-eight volunteers participated, 27 of which (96.4%) forgot to take at least one pill during the experiment. Among the lower undergraduates, 28.57% interrupted at least one medication. As for the higher undergraduates and residents, this happened with 71.43% of them. There were more adherence failures than predicted by the participants themselves. In realistic dosages, levothyroxine, angiotensin-converting enzyme inhibitors and metformin were the drugs reported to be the most difficult. 96% of the volunteers strongly agreed that doctor and patient’s agreement regarding the treatment correlates with good adherence. Conclusion: Understanding the factors that affect adherence and how to handle them is essential for a doctor, as well as a good bond with the patient. The teaching of these abilities is very necessary. Further studies are needed to reach more undergraduate students and to highlight the relevance of simulations in the medical education setting.
DOI: 10.5281/zenodo.6585940
title: Data from: Early Firm Engagement, Government Research Funding, and the Privatization of Public Knowledge

description: This is a demo and partial dataset of a full dataset of paper- patent pair from chinese chemical scholars. The full dataset covers the published English papers and the paired patents by some of the scholars of the chemical and pharmaceutical field who received the Distinguished Young Scholars of the National Science Foundation of China (NSFC) during 2009–2018. Data related to the papers are obtained from the China National Knowledge Infrastructure (CNKI) and WoS; data related to the scholars are obtained from the NSFC website, the Ministry of Science and Technology of China (MSTC) website, and the scholars' home pages; and data related to the patents are obtained from the CNIPA website. The dataset also covers the data on the average number of patent infringement cases at the prefecture level from China Judgements Online (CJO) using crawlers and text mining techniques to reflect the degree of local intellectual property protection (IPR). Besides the paper information, the dataset also contains the corresponding scholars' funding information and the paired patents[1] information gathered through “patent–paper pairs.” This demo datasets covers about 1/15 samples of the full datast. The detail variable explanation will be found in the "label" and "Notes" column after every variable name in the DTA data file. As a series of related papers are published, we will gradually publish the full data set. [1] A small number of papers may be paired with multiple patents. We deal with the situation of multiple paired patents when constructing variables. See “Variable” section of original paper for detailed illustrations.
description: The detail variable explanation will be found in the "label" column after every variable name in the data file
DOI: 10.5281/zenodo.6585939
title: Data from: Early Firm Engagement, Government Research Funding, and the Privatization of Public Knowledge

description: This is a demo and partial dataset of a full dataset of paper- patent pair from chinese chemical scholars. The full dataset covers the published English papers and the paired patents by some of the scholars of the chemical and pharmaceutical field who received the Distinguished Young Scholars of the National Science Foundation of China (NSFC) during 2009–2018. Data related to the papers are obtained from the China National Knowledge Infrastructure (CNKI) and WoS; data related to the scholars are obtained from the NSFC website, the Ministry of Science and Technology of China (MSTC) website, and the scholars' home pages; and data related to the patents are obtained from the CNIPA website. The dataset also covers the data on the average number of patent infringement cases at the prefecture level from China Judgements Online (CJO) using crawlers and text mining techniques to reflect the degree of local intellectual property protection (IPR). Besides the paper information, the dataset also contains the corresponding scholars' funding information and the paired patents[1] information gathered through “patent–paper pairs.” This demo datasets covers about 1/15 samples of the full datast. The detail variable explanation will be found in the "label" and "Notes" column after every variable name in the DTA data file. As a series of related papers are published, we will gradually publish the full data set. [1] A small number of papers may be paired with multiple patents. We deal with the situation of multiple paired patents when constructing variables. See “Variable” section of original paper for detailed illustrations.
description: The detail variable explanation will be found in the "label" column after every variable name in the data file
DOI: 10.6084/m9.figshare.19900980.v1
title: Sugar content variation in elephant grass germplasm

description: ABSTRACT: The objective of this study was to estimate sugar content variation (°Brix) in 95 accessions from the elephant grass germplasm active bank of Embrapa Dairy Cattle research center, located in Coronel Pacheco, MG, Brazil. The accessions with the highest sugar content were identified, and the effect of plant age on sugar concentration was evaluated. The experiment was conducted in randomized blocks design with two replications. Sugar content analysis occurred twice during the growth-cycle (at 70 and 100 days) along two points of the stem, one 30 cm from the base and the other at the midpoint. The analysis of variance considered the split plot model, with accessions as main plots and plant age as subplots. The means were compared using the Scott Knott test. While there was sugar content variation between accessions, increased plant age had no significant effect on the sugar content. However, some accessions did have a significant increase or decrease in sugar content as they aged. The highest and lowest mean sugar content was 6.96% (in the accession BAG80) and 4.03% (in the accession BAG13) °Brix, respectively.
DOI: 10.6084/m9.figshare.19900980
title: Sugar content variation in elephant grass germplasm

description: ABSTRACT: The objective of this study was to estimate sugar content variation (°Brix) in 95 accessions from the elephant grass germplasm active bank of Embrapa Dairy Cattle research center, located in Coronel Pacheco, MG, Brazil. The accessions with the highest sugar content were identified, and the effect of plant age on sugar concentration was evaluated. The experiment was conducted in randomized blocks design with two replications. Sugar content analysis occurred twice during the growth-cycle (at 70 and 100 days) along two points of the stem, one 30 cm from the base and the other at the midpoint. The analysis of variance considered the split plot model, with accessions as main plots and plant age as subplots. The means were compared using the Scott Knott test. While there was sugar content variation between accessions, increased plant age had no significant effect on the sugar content. However, some accessions did have a significant increase or decrease in sugar content as they aged. The highest and lowest mean sugar content was 6.96% (in the accession BAG80) and 4.03% (in the accession BAG13) °Brix, respectively.