DOI: 10.5061/dryad.xgxd254pk
title: Supporting information for: Discrimination ability of central visual field testing using stimulus size I, II, and III and relationship with macular ganglion cell thickness in chiasmal compression

description: Purpose: To compare the relationship between macular ganglion cell layer
 (mGCL) thickness and 10-2 visual field (VF) sensitivity using different
 stimulus sizes in patients with temporal hemianopia from chiasmal
 compression. Methods: A cross-sectional study was conducted involving 30
 eyes from 25 patients with temporal VF loss on 24-2 SITA standard
 automated perimetry due to previous chiasmal compression and 30 healthy
 eyes (23 controls). Optical coherence tomography (OCT) of the macular area
 and 10-2 VF testing using Goldmann stimulus size I (GI), II (GII), and III
 (GIII) were performed in the Octopus 900 perimeter. For the sake of
 analysis, mGCL thickness and VF data were segregated into four quadrants
 (two temporal and two nasal) and two halves (temporal and nasal) centered
 on the fovea, and the groups were compared using generalized estimated
 equations. The discrimination ability of GI, GII, and GIII was evaluated,
 as was the correlation between mGCL and 10-2 VF sensitivity using GI, GII,
 and GIII.  Results: All mGCL parameters were significantly
 reduced in patients compared to controls. 10-2 VF test sensitivity using
 GI, GII, and GIII was significantly lower in patients than in controls
 (p≤0.008) for all parameters, except the three nasal divisions when using
 GI (p=0.41, 0.07 and 0.18) Significant correlations were found between
 temporal VF sectors (all stimulus sizes) and the corresponding nasal mGCL
 measurements, with similar discrimination ability. Significant
 correlations were also observed between all three nasal VF divisions and
 the corresponding temporal mGCL thickness when using stimulus sizes I and
 II, but not stimulus size III. Conclusions: On 10-2 VF testing, GII
 outperformed GI and GIII with regard to discrimination ability and
 structure-function correlation with mGCL thickness in chiasmal
 compression. Our findings suggest that the use of GII can enhance the
 diagnostic power of 10-2 VF testing, although further studies are
 necessary to support this conclusion.
description: In this study, our purpose was to compare the relationship
 between macular ganglion cell layer (mGCL) thickness and 10-2 visual field
 (VF) sensitivity using different stimulus sizes in patients with temporal
 hemianopia from chiasmal compression.  To do so, a cross-sectional study
 was conducted involving 30 eyes from 25 patients with temporal VF loss on
 24-2 SITA standard automated perimetry due to previous chiasmal
 compression and 30 healthy eyes (23 controls). Optical coherence
 tomography (OCT) of the macular area and 10-2 VF testing using Goldmann
 stimulus size I (GI), II (GII), and III (GIII) were performed in the
 Octopus 900 perimeter. For the sake of analysis, mGCL thickness and VF
 data were segregated into four quadrants (two temporal and two nasal) and
 two halves (temporal and nasal) centered on the fovea, and the groups were
 compared using generalized estimated equations. The discrimination ability
 of GI, GII, and GIII was evaluated, as was the correlation between mGCL
 and 10-2 VF sensitivity using GI, GII, and GIII. The
 dataset is clinical findings collected from visual field examinations and
 on optical coherence tomography examinations. Data are from patients and
 controls of the study.
description: # DATA WITH SUPPORTING INFORMATION FOR THE MANUSCRIPT PONE-D-23-26160R1
 Give a brief summary of
 dataset contents, contextualized in experimental procedures and results.
 ## Description of the data and file structure DATA ARE PRESENTED IN AN
 EXCELL FILE INCLUDING 1\) Demographic data of participants ·       column
 A has a list of patients (from line 3 to 32) and controls (from line 35 to
 64). When the number is repeated it indicates that the two eyes of the
 patient or control were evaluated. column B indicates the gender of
 patient or control. Column C the age of the subject. Column D the eye
 studied (RIGHT EYE=OD, LEFT EYE=OE)  2\) Structural parameters evalated
 ·        Structural parameters (macular ganglion cell layer (mGCL)
 thickness in microns obtained using optical coherence tomography in
 patients and controls (Columns: F, G, H, I, J, K and L) divided in
 qudrants (SN=SUPERONASAL, ST=SUPEROTEMPORAL, IN=INFERONASAL,
 IT=INFEROTEMPORAL), in the nasal hemiretina, temporal hemiretina and as
 global average. 3\) Functional parameters evaluated using central 10-2
 visual field on Octopus 900 perimeter ·        Visual field parameters
 (deviation from normal in decibels) obtained on 10-2 test using target
 size III stimulus in each quadrant, as global average, in the temporal
 hemifield and in the nasal hemifield (columns Q, R, S, T, and U).
 ST=SUPEROTEMPORAL, IT=INFEROTEMPORAL, SN=SUPERONASAL, IN=INFERONASAL
 ·        Visual field parameters (deviation from normal in decibels)
 obtained on 10-2 test using target size II stimulus in each quadrant, as
 global average, in the temporal hemifield and in the nasal hemifield
 (columns W, X, Y, Z, AA, AB, and AC). ST=SUPEROTEMPORAL,
 IT=INFEROTEMPORAL, SN=SUPERONASAL, IN=INFERONASAL ·        Visual field
 parameters (deviation from normal in decibels) obtained on 10-2 test using
 target size I stimulus in each quadrant, as global average, in the
 temporal hemifield and in the nasal hemifield (columns AE,, AF, AG, AH,
 AI, AJ and AK). ST=SUPEROTEMPORAL, IT=INFEROTEMPORAL, SN=SUPERONASAL,
 IN=INFERONASAL ## Sharing/Access information This is a section for linking
 to other ways to access the data, and for linking to sources the data is
 derived from, if any. Links to other publicly accessible locations of the
 data: * Data was derived from the following sources: *
 ## Code/Software This is an optional, freeform section for describing any
 code in your submission and the software used to run it. Describe any
 scripts, code, or notebooks (e.g., R, Python, Mathematica, MatLab) as well
 as the software versions (including loaded packages) that you used to run
 those files. If your repository contains more than one file whose
 relationship to other scripts is not obvious, provide information about
 the workflow that you used to run those scripts and notebooks.