cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.5281/zenodo.14801683
title: Morbidity and mortality in adults with a Fontan circulation beyond the fourth decade of life

description: Abstract



Aims: To evaluate the late outcomes of adults (above 35 years) with a Fontan-type circulation, for whom current data on morbidity and mortality are lacking.

Methods and results: Data were collected retrospectively on consecutive patients with Fontan circulation above the age of 35 years followed in three European specialist centres. Overall, 115 Fontan patients were included [median age 35 (range 35-48) years, 47.8% female]. The most common underlying congenital heart disease diagnosis was tricuspid atresia (n = 58, 50.4%), and the age at first Fontan completion was 9.1 (interquartile range 5.0-15.8) years. Almost two-thirds (61.7%) of patients had undergone an atriopulmonary Fontan, and 23.5% had received a total cavopulmonary connection. One-third required repeat surgery or intervention. Most patients (55.9%) were in New York Heart Association functional class II or class I (30.6%), 76 (66.1%) patients had experienced at least one arrhythmia, and eight (7.0%) protein-losing enteropathy. At a median follow-up of 5.0 (2.4-10.3) years, 15 (13.0%) patients were referred for transplantation assessment and 19 (16.5%) patients died, mainly from heart failure (84.2%). Univariable predictors of death or transplantation included lower serum albumin level [hazard ratio (HR) 1.09 per g/L decrease, 95% confidence interval (CI): 1.04-1.15, P = 0.0009], prior heart failure admission (HR 4.28, 95% CI:1.75-10.44, P = 0.001), prior atrial tachycardia or flutter (HR 3.02, 95% CI: 1.23-7.38, P = 0.02), and baseline pulmonary vasodilator therapy (HR 8.59, 95% CI:1.05-70.13, P = 0.04). Lower serum albumin and prior atrial tachycardia or flutter remained significant on bivariable analysis.

Conclusion: Our study highlights the significant morbidity and mortality in older adults with a Fontan-type circulation, emphasizing the need for lifelong specialist surveillance with frequent risk stratification, close monitoring, and early consideration for transplantation assessment.
DOI: 10.5281/zenodo.14801684
title: Morbidity and mortality in adults with a Fontan circulation beyond the fourth decade of life

description: Abstract



Aims: To evaluate the late outcomes of adults (above 35 years) with a Fontan-type circulation, for whom current data on morbidity and mortality are lacking.

Methods and results: Data were collected retrospectively on consecutive patients with Fontan circulation above the age of 35 years followed in three European specialist centres. Overall, 115 Fontan patients were included [median age 35 (range 35-48) years, 47.8% female]. The most common underlying congenital heart disease diagnosis was tricuspid atresia (n = 58, 50.4%), and the age at first Fontan completion was 9.1 (interquartile range 5.0-15.8) years. Almost two-thirds (61.7%) of patients had undergone an atriopulmonary Fontan, and 23.5% had received a total cavopulmonary connection. One-third required repeat surgery or intervention. Most patients (55.9%) were in New York Heart Association functional class II or class I (30.6%), 76 (66.1%) patients had experienced at least one arrhythmia, and eight (7.0%) protein-losing enteropathy. At a median follow-up of 5.0 (2.4-10.3) years, 15 (13.0%) patients were referred for transplantation assessment and 19 (16.5%) patients died, mainly from heart failure (84.2%). Univariable predictors of death or transplantation included lower serum albumin level [hazard ratio (HR) 1.09 per g/L decrease, 95% confidence interval (CI): 1.04-1.15, P = 0.0009], prior heart failure admission (HR 4.28, 95% CI:1.75-10.44, P = 0.001), prior atrial tachycardia or flutter (HR 3.02, 95% CI: 1.23-7.38, P = 0.02), and baseline pulmonary vasodilator therapy (HR 8.59, 95% CI:1.05-70.13, P = 0.04). Lower serum albumin and prior atrial tachycardia or flutter remained significant on bivariable analysis.

Conclusion: Our study highlights the significant morbidity and mortality in older adults with a Fontan-type circulation, emphasizing the need for lifelong specialist surveillance with frequent risk stratification, close monitoring, and early consideration for transplantation assessment.
DOI: 10.21410/7e4/kpdyny/wsepge
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DOI: 10.21410/7e4/kpdyny/khh1b2
title: en.json

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DOI: 10.21410/7e4/kpdyny/qinsgt
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DOI: 10.21410/7e4/kpdyny/oevfel
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DOI: 10.21410/7e4/kpdyny/rxm4th
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DOI: 10.21410/7e4/kpdyny/gblypc
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DOI: 10.21410/7e4/kpdyny/am8wsz
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DOI: 10.21410/7e4/kpdyny/v3keyp
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DOI: 10.21410/7e4/kpdyny/8bsgqq
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DOI: 10.21410/7e4/kpdyny/bvbvok
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DOI: 10.21410/7e4/kpdyny/pxdl9l
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DOI: 10.21410/7e4/kpdyny/oobqmf
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DOI: 10.21410/7e4/kpdyny/v5ytde
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DOI: 10.21410/7e4/kpdyny/77s0v3
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DOI: 10.21410/7e4/kpdyny/jxzzas
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DOI: 10.21410/7e4/kpdyny/71dwds
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DOI: 10.21410/7e4/kpdyny/cbcxva
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DOI: 10.21410/7e4/kpdyny/sc0mq1
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DOI: 10.21410/7e4/kpdyny/b3kabp
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DOI: 10.21410/7e4/kpdyny/jz4pfl
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DOI: 10.21410/7e4/kpdyny/eejsim
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DOI: 10.21410/7e4/kpdyny/tcdzia
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DOI: 10.21410/7e4/kpdyny/okvnca
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DOI: 10.21410/7e4/kpdyny/gpywmp
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DOI: 10.21410/7e4/kpdyny/zkjkch
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DOI: 10.21410/7e4/kpdyny/qv5xsi
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DOI: 10.21410/7e4/kpdyny/6r2bjw
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DOI: 10.21410/7e4/kpdyny/aozt8p
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DOI: 10.21410/7e4/kpdyny/dbtk86
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DOI: 10.21410/7e4/kpdyny/g8arac
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DOI: 10.21410/7e4/kpdyny/yvxz1j
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DOI: 10.21410/7e4/kpdyny/i8gzbw
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DOI: 10.15468/dl.8b4zw9
title: Occurrence Download

description: A dataset containing 4 species occurrences available in GBIF matching the query:
{
 "and" : [
 "BasisOfRecord is Specimen",
 "DatasetKey is Royal Botanic Gardens, Kew - Herbarium Specimens",
 "TaxonKey is Pilea auriculata Liebm."
 ]
}

 The dataset includes 4 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0011332-250127130748423/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.21410/7e4/kpdyny/jio8em
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DOI: 10.5519/qd.ixl5eqzw
title: Query on the Natural History Museum Data Portal (data.nhm.ac.uk) (709 records)
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