cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.11568528.v1
title: Substantial intrinsic variability in chemoradiosensitivity of newly established anaplastic thyroid cancer cell-lines

description: <b>Background:</b> Well characterized human cell lines are needed for preclinical treatment studies of anaplastic thyroid cancer (ATC). <b>Aims/Objectives:</b> The aim was to establish, verify and characterize a panel of ATC cell lines. <b>Material and methods:</b> Cell lines were established from ATC fine-needle aspiration biopsies and characterized genetically and functionally regarding treatment sensitivities. <b>Results:</b> Eight cell lines were established <i>in vitro</i> and the anaplastic thyroid origin was verified. Seven of the cell lines were also grown as xenografts. The cell lines harboured complex karyotypes with modal numbers in hyperdiploid to near-pentaploid range. Five were <i>TP53</i> mutated and three carried the <i>BRAF</i><sup>V600E</sup> mutation. None had rearrangements of <i>RET</i>. For doxorubicin, IC<sub>50</sub> ranged from 0.42 to 46 nmol/L and for paclitaxel from 1.6 to 196 nmol/L. Radiation sensitivity varied between 2.6 and 6.3 Gy. Two of the <i>BRAF</i> mutated cell lines displayed high sensitivity to vemurafenib, while the third was similar to the wild-type ones. <b>Conclusions and significance:</b> We describe a series of new ATC cell lines demonstrating large heterogeneity in the response to cytostatic drugs and the BRAF inhibitor vemurafenib. The observations are relevant to future attempts to optimize treatment combinations for ATC.
DOI: 10.5522/04/11568492
title: Internet of Things Discrete Choice Experiment - Security Camera data

description: The data are for a discrete choice experiment that examined the impact of security labels, device functionality and price on consumer decision making. This dataset is for internet connected security cameras. <br>Article will be published in PlosOne.<br>
DOI: 10.5522/04/11568492.v1
title: Internet of Things Discrete Choice Experiment - Security Camera data

description: The data are for a discrete choice experiment that examined the impact of security labels, device functionality and price on consumer decision making. This dataset is for internet connected security cameras. <br>Article will be published in PlosOne.<br>
DOI: 10.5522/04/11568438
title: Internet of Things Discrete Choice Experiment - Thermostats data

description: The data are for a discrete choice experiment that examined the impact of security labels, device functionality and price on consumer decision making. This dataset is for internet connected Thermostats.<br>Article will be published in PlosOne.<br>
DOI: 10.5522/04/11568438.v1
title: Internet of Things Discrete Choice Experiment - Thermostats data

description: The data are for a discrete choice experiment that examined the impact of security labels, device functionality and price on consumer decision making. This dataset is for internet connected Thermostats.<br>Article will be published in PlosOne.<br>
DOI: 10.6084/m9.figshare.11568327
title: supplemental file

description: Supplemental information for AJP-Cell Physiology.
DOI: 10.6084/m9.figshare.11568327.v2
title: supplemental file

description: Supplemental information for AJP-Cell Physiology.
DOI: 10.22023/mdx.11568306
title: Phrases used in the validation of the text classifier of the virtual assistant for personalised asthma management (ADAPT)

description: This data set was used to validate the text classifier of the virtual assistant that is reported in ADAPT.<br>These phrases are those suggested by people with asthma and carers of people with asthma to represent normal or deteriorated health status. The phrases were collected through a questionnaire that was spread through the Patients Advisory Group of Asthma UK.
DOI: 10.6084/m9.figshare.11568327.v1
title: Untitled Item

description: Supplemental information for AJP-Cell Physiology.
DOI: 10.22023/mdx.11568288
title: Phrases used in the training of the text classifier of the virtual assistant for personalised asthma management (ADAPT)

description: This data set was used to train the text classifier of the virtual assistant that is reported in ADAPT.These phrases were generated based on the outcomes of a set of interviews and the application of a questionnaire about using mobile health technology for personalised asthma management.
DOI: 10.22023/mdx.11568288.v1
title: Phrases used in the training of the text classifier of the virtual assistant for personalised asthma management (ADAPT)

description: This data set was used to train the text classifier of the virtual assistant that is reported in ADAPT.These phrases were generated based on the outcomes of a set of interviews and the application of a questionnaire about using mobile health technology for personalised asthma management.
DOI: 10.6084/m9.figshare.11568000
title: IMPROVE-IT2: implementing noninvasive circulating tumor DNA analysis to optimize the operative and postoperative treatment for patients with colorectal cancer – intervention trial 2. Study protocol

description: IMPROVE-IT2: implementing noninvasive circulating tumor DNA analysis to optimize the operative and postoperative treatment for patients with colorectal cancer – intervention trial 2. Study protocol
DOI: 10.6084/m9.figshare.11568000.v1
title: IMPROVE-IT2: implementing noninvasive circulating tumor DNA analysis to optimize the operative and postoperative treatment for patients with colorectal cancer – intervention trial 2. Study protocol

description: IMPROVE-IT2: implementing noninvasive circulating tumor DNA analysis to optimize the operative and postoperative treatment for patients with colorectal cancer – intervention trial 2. Study protocol
DOI: 10.6084/m9.figshare.11567982
title: Biomechanical and physiological effects of human-machine system elasticity on cross-country sit skiing

description: Experimental data about force, cycle characteristics, respiratory metabolism and muscle activities
DOI: 10.6084/m9.figshare.11567985
title: Waiting times and treatment following cancer diagnosis: comparison between immigrants and the Norwegian host population

description: <b>Background:</b> There are concerns about timely access to appropriate cancer treatment for the growing immigrant population in Norway. This study aims to compare waiting times between cancer diagnosis and start of cancer treatment, as well as treatment patterns between immigrants in Norway and the host population. <b>Material and methods:</b> We performed a nationwide, registry-based study with individual-level data, including 213,320 Norwegians and 8324 immigrants diagnosed with breast, colorectal, lung or prostate cancer in 1990–2014. Differences in time from diagnosis to treatment and in treatment patterns were described for the selected cancer sites. The Cox and logistic regressions were used to adjust for patient and tumour characteristics. <b>Results:</b> After adjustment for covariates, hazard ratios for time from diagnosis to treatment for non-Western immigrants compared to Norwegians were 0.88 (95% confidence interval (CI): 0.82–0.95) for breast cancer and 0.84 (95% CI: 0.75–0.95) for lung cancer, indicating longer waiting times. Treatment patterns in the four major cancer sites were similar among immigrants and the Norwegian host population, except for breast cancer, where women from East and South Asia received less breast-conserving surgery than the Norwegian host population (adjusted odds ratios 0.65 (95% CI: 0.46–0.93) for East Asians and 0.75 (95% CI: 0.50–1.13) for South Asians). <b>Conclusions:</b> The present study reports delayed treatment for lung and breast cancer among immigrants from non-Western countries in Norway. Systematic differences in cancer treatment were not detected. However, less breast-conserving surgery among breast cancer patients from Asia compared to Norwegians was observed.
DOI: 10.6084/m9.figshare.11567985.v1
title: Waiting times and treatment following cancer diagnosis: comparison between immigrants and the Norwegian host population

description: <b>Background:</b> There are concerns about timely access to appropriate cancer treatment for the growing immigrant population in Norway. This study aims to compare waiting times between cancer diagnosis and start of cancer treatment, as well as treatment patterns between immigrants in Norway and the host population. <b>Material and methods:</b> We performed a nationwide, registry-based study with individual-level data, including 213,320 Norwegians and 8324 immigrants diagnosed with breast, colorectal, lung or prostate cancer in 1990–2014. Differences in time from diagnosis to treatment and in treatment patterns were described for the selected cancer sites. The Cox and logistic regressions were used to adjust for patient and tumour characteristics. <b>Results:</b> After adjustment for covariates, hazard ratios for time from diagnosis to treatment for non-Western immigrants compared to Norwegians were 0.88 (95% confidence interval (CI): 0.82–0.95) for breast cancer and 0.84 (95% CI: 0.75–0.95) for lung cancer, indicating longer waiting times. Treatment patterns in the four major cancer sites were similar among immigrants and the Norwegian host population, except for breast cancer, where women from East and South Asia received less breast-conserving surgery than the Norwegian host population (adjusted odds ratios 0.65 (95% CI: 0.46–0.93) for East Asians and 0.75 (95% CI: 0.50–1.13) for South Asians). <b>Conclusions:</b> The present study reports delayed treatment for lung and breast cancer among immigrants from non-Western countries in Norway. Systematic differences in cancer treatment were not detected. However, less breast-conserving surgery among breast cancer patients from Asia compared to Norwegians was observed.
DOI: 10.17028/rd.lboro.11567931
title: Complexity characteristics and measurement within engineering systems. Appendices.

description: Abstract:Complexity is a significant factor in the development of new products and systems; generally speaking, the higher the complexity, the more difficult products and systems are going to be to design and develop. There are a number of different factors that influence complexity within systems, namely: interoperability; upgradability; adaptability; evolving requirements; system size; automation requirements; performance requirements; support requirements; sustainability; reliability; the need for increased product lifespan; and finally, the length of time systems take to develop. There is, at present, no common language to describe complexity within engineered systems; this language needs to be developed in order to help industry cope with increasing product complexity and thus meet customer demands. This thesis represents a start in the development of that language, and thus an understanding of systems complexity. The thesis offers a framework for complexity analysis within systems, one which identifies some of the key complexity characteristics that need to be taken into consideration, and which embraces complexity problems, definitions, concepts and classifications, origins and coping mechanisms. It has also has been developed in terms of a measurement approach, thereby allowing for a meaningful comparison between products, and an understanding of the complexities within them. This framework was developed using information collected from academic literature and from more specific case studies. Each complexity characteristic was investigated, and the interactions between characteristics were identified; these interactions allow us to understand complexity and help to develop a common language. The thesis develops a measurement technique that quantifies various complexity characteristics in terms of the framework laid down, thus enabling a quantified understanding of complexity within systems. This new measurement approach was tested on a set of recent case studies, and the complexity characteristics produced by the measurement technique were, in turn, tested against attributes of the system. The framework itself is always evolving - it incorporates new complexity characteristics. Nevertheless, such evolution can only further our understanding of complexity. Further work, to explore and integrate the approach demonstrated in this thesis into an automated tool, and test its robustness, along with a continual development of other elements of the framework, such as a classification of complexity, is recommended.<br>
DOI: 10.17028/rd.lboro.11567931.v1
title: Complexity characteristics and measurement within engineering systems. Appendices.

description: Abstract:Complexity is a significant factor in the development of new products and systems; generally speaking, the higher the complexity, the more difficult products and systems are going to be to design and develop. There are a number of different factors that influence complexity within systems, namely: interoperability; upgradability; adaptability; evolving requirements; system size; automation requirements; performance requirements; support requirements; sustainability; reliability; the need for increased product lifespan; and finally, the length of time systems take to develop. There is, at present, no common language to describe complexity within engineered systems; this language needs to be developed in order to help industry cope with increasing product complexity and thus meet customer demands. This thesis represents a start in the development of that language, and thus an understanding of systems complexity. The thesis offers a framework for complexity analysis within systems, one which identifies some of the key complexity characteristics that need to be taken into consideration, and which embraces complexity problems, definitions, concepts and classifications, origins and coping mechanisms. It has also has been developed in terms of a measurement approach, thereby allowing for a meaningful comparison between products, and an understanding of the complexities within them. This framework was developed using information collected from academic literature and from more specific case studies. Each complexity characteristic was investigated, and the interactions between characteristics were identified; these interactions allow us to understand complexity and help to develop a common language. The thesis develops a measurement technique that quantifies various complexity characteristics in terms of the framework laid down, thus enabling a quantified understanding of complexity within systems. This new measurement approach was tested on a set of recent case studies, and the complexity characteristics produced by the measurement technique were, in turn, tested against attributes of the system. The framework itself is always evolving - it incorporates new complexity characteristics. Nevertheless, such evolution can only further our understanding of complexity. Further work, to explore and integrate the approach demonstrated in this thesis into an automated tool, and test its robustness, along with a continual development of other elements of the framework, such as a classification of complexity, is recommended.<br>
DOI: 10.6084/m9.figshare.11567907
title: Supplementary Material for: Combining Serum Cystatin C and Urinary N-Acetyl-Beta-D-Glucosaminidase Improves the Precision for Acute Kidney Injury Diagnosis after Resection of Intracranial Space-Occupying Lesions

description: <b><i>Background:</i></b> Postoperative acute kidney injury (AKI) is frequent and associated with adverse outcomes. Unfortunately, the early diagnosis of AKI remains a challenge. Combining functional and tubular damage biomarkers may provide better precision for AKI detection. However, the diagnostic accuracy of this combination for AKI after neurosurgery is unclear. Serum cystatin C (sCysC) and urinary albumin/creatinine ratio (uACR) are considered functional biomarkers, while urinary N-acetyl-β-D-glucosaminidase (uNAG) represents tubular damage. We aimed to assess the performances of these clinical available biomarkers and their combinations for AKI prediction after resection of intracranial space-occupying lesions. <b><i>Methods:</i></b> A prospective study was conducted, enrolling adults undergoing resection of intracranial space-occupying lesions and admitted to the neurosurgical intensive care unit. The discriminative abilities of postoperative sCysC, uNAG, uACR, and their combinations in predicting AKI were compared using the area under the receiver operating characteristic curve (AUC-ROC), continuous net reclassification index (cNRI), and incremental discrimination improvement (IDI). <b><i>Results:</i></b> Of 605 enrolled patients, AKI occurred in 67 patients. The cutoff values of sCysC, uNAG, and uACR to predict postoperative AKI were 0.72 mg/L, 19.98 U/g creatinine, and 44.21 mg/g creatinine, respectively. For predicting AKI, the composite of sCysC and uNAG (AUC-ROC = 0.785) outperformed either individual biomarkers or the other two panels (uNAG plus uACR or sCysC plus uACR). Adding this panel to the predictive model improved the AUC-ROC to 0.808. Moreover, this combination significantly improved risk reclassification over the clinical model alone, with cNRI (0.633) and IDI (0.076). Superior performance of this panel was further confirmed with bootstrap internal validation. <b><i>Conclusions:</i></b> Combination of functional and tubular damage biomarkers improves the predictive accuracy for AKI after resection of intracranial space-occupying lesions.
DOI: 10.6084/m9.figshare.11567652
title: Rey_et_al.xlsx

description: Rey_et_alSpreadsheet summarizing datasets
DOI: 10.6084/m9.figshare.11567556
title: Data Gephi

description: Data for Gephi Software<br>
DOI: 10.6084/m9.figshare.11567652.v1
title: Rey_et_al.xlsx

description: Rey_et_alSpreadsheet summarizing datasets
DOI: 10.6084/m9.figshare.11567523
title: Supplementary Material for: Deranged Iron Status Evidenced by Iron Deficiency Characterizes Patients with Hidradenitis Suppurativa

description: <b><i>Background:</i></b> Proinflammatory activation and autoimmune processes underlie the pathophysiology of hidradenitis suppurativa (HS). Iron deficiency (ID) is frequently present in inflammation-mediated chronic diseases, irrespective of anemia. <b><i>Objectives:</i></b> We aimed to characterize iron status in patients with HS. <b><i>Methods:</i></b> Serum concentrations of ferritin, transferrin saturation (Tsat), soluble transferrin receptor and hepcidin were assessed as the biomarkers of iron status in 74 patients with HS and 44 healthy subjects. ID was defined as ferritin &lt;100 µg/L or ferritin 100–299 µg/L with Tsat &lt;20% (following the definition used in the other studies in chronic disease). <b><i>Results:</i></b> Compared with controls, patients with HS demonstrated a deranged iron status as evidenced by decreased levels of ferritin (91 ± 87 vs. 157 ± 99 µg/L), Tsat (21.5 ± 10.8 vs. 42.2 ± 11.7%) and hepcidin (31.3 ± 25.9 vs. 44.2 ± 22.0 ng/mL) (all <i>p</i> &lt; 0.05 vs. controls). There was also a trend toward higher values of soluble transferrin receptor (1.23 ± 0.35 vs. 1.12 ± 0.19 mg/L) (<i>p</i> = 0.09 vs. controls). Disease severity (assessed with the Hidradenitis Suppurativa Severity Index and the 3-degree Hurley scale) did not differentiate iron status biomarkers. ID was present in 75% of HS patients, and its prevalence was not related with disease severity (Hurley I/II/III – 82 vs. 73 vs. 67%). In HS, none of the iron status biomarkers correlated with the levels of interleukin-6 (a marker of proinflammatory activation). <b><i>Conclusions:</i></b> The majority of HS patients demonstrate derangements in iron status typical of ID. These abnormalities are neither related to proinflammatory activation nor associated with disease severity. Whether it may have a therapeutic impact needs to be further studied.
DOI: 10.6084/m9.figshare.11567523.v1
title: Supplementary Material for: Deranged Iron Status Evidenced by Iron Deficiency Characterizes Patients with Hidradenitis Suppurativa

description: <b><i>Background:</i></b> Proinflammatory activation and autoimmune processes underlie the pathophysiology of hidradenitis suppurativa (HS). Iron deficiency (ID) is frequently present in inflammation-mediated chronic diseases, irrespective of anemia. <b><i>Objectives:</i></b> We aimed to characterize iron status in patients with HS. <b><i>Methods:</i></b> Serum concentrations of ferritin, transferrin saturation (Tsat), soluble transferrin receptor and hepcidin were assessed as the biomarkers of iron status in 74 patients with HS and 44 healthy subjects. ID was defined as ferritin &lt;100 µg/L or ferritin 100–299 µg/L with Tsat &lt;20% (following the definition used in the other studies in chronic disease). <b><i>Results:</i></b> Compared with controls, patients with HS demonstrated a deranged iron status as evidenced by decreased levels of ferritin (91 ± 87 vs. 157 ± 99 µg/L), Tsat (21.5 ± 10.8 vs. 42.2 ± 11.7%) and hepcidin (31.3 ± 25.9 vs. 44.2 ± 22.0 ng/mL) (all <i>p</i> &lt; 0.05 vs. controls). There was also a trend toward higher values of soluble transferrin receptor (1.23 ± 0.35 vs. 1.12 ± 0.19 mg/L) (<i>p</i> = 0.09 vs. controls). Disease severity (assessed with the Hidradenitis Suppurativa Severity Index and the 3-degree Hurley scale) did not differentiate iron status biomarkers. ID was present in 75% of HS patients, and its prevalence was not related with disease severity (Hurley I/II/III – 82 vs. 73 vs. 67%). In HS, none of the iron status biomarkers correlated with the levels of interleukin-6 (a marker of proinflammatory activation). <b><i>Conclusions:</i></b> The majority of HS patients demonstrate derangements in iron status typical of ID. These abnormalities are neither related to proinflammatory activation nor associated with disease severity. Whether it may have a therapeutic impact needs to be further studied.
DOI: 10.6084/m9.figshare.11567460
title: Biomechanical and physiological effects of human-machine system elasticity on cross-country sit skiing

description: Experimental data about force, cycle characteristics, respiratory metabolism and muscle activities
DOI: 10.6084/m9.figshare.11567403
title: Supplementary Material for: The Key Role of VEGF in the Cross Talk between Pterygium and Dry Eye and Its Clinical Significance

description: <b><i>Purpose:</i></b> To examine whether dry eye severity is a risk factor for pterygium activity and whether vascular endothelial growth factor (VEGF) is crucial in the cross talk between pterygium and dry eye. <b><i>Methods:</i></b> A total of 103 patients with primary pterygium (Pteg) were included in the study group; they were divided into 2 groups according to the complication of dry eye (DE) (Pteg + DE group, Pteg – DE group). Further, 60 patients with just dry eye (DE group) and 60 normal individuals (normal) were included as 2 control groups. DE severity and pterygium activity were measured, and unstimulated tear samples and pterygium tissues were collected for cytokine detection. <b><i>Results:</i></b> (1) Tear detection: VEGF expression increased in the Pteg + DE group compared to the Pteg – DE, DE, and normal control groups; VEGF was especially increased in the active Pteg + DE group. VEGF concentration was positively correlated with pterygium activity. (2) Tissue detection: the mRNA expression of VEGF was upregulated in the active pterygium group. <b><i>Conclusions:</i></b> Inflammation played an important role in the development of dry eye and pterygium. VEGF was the core molecule in the cross talk, which might explain the high incidence of the coexistence of these 2 diseases.
DOI: 10.6084/m9.figshare.11567460.v1
title: Biomechanical and physiological effects of human-machine system elasticity on cross-country sit skiing

description: Experimental data about force, cycle characteristics, respiratory metabolism and muscle activities
DOI: 10.6084/m9.figshare.11567460.v2
title: Biomechanical and physiological effects of human-machine system elasticity on cross-country sit skiing

description: Experimental data about force, cycle characteristics, respiratory metabolism and muscle activities