cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.24972729.v1
title: Montanari et al NatComm source data file.xlsx

description: The survival of animals depends, among other things, on their ability to identify threats in their surrounding environment. Senses such as olfaction, vision and taste play an essential role in sampling their living environment, including microorganisms, some of which are potentially pathogenic. This study focuses on the mechanisms of detection of bacteria by the <i>Drosophila</i> gustatory system. We demonstrate that the peptidoglycan (PGN) that forms the cell wall of bacteria triggers an immediate feeding aversive response when detected by the gustatory system of adult flies. Although we identify ppk23+ and Gr66a+ gustatory neurons as necessary to transduce fly response to PGN, we demonstrate that they play very different roles in the process. Time-controlled functional inactivation and <i>in vivo</i> calcium imaging demonstrate that while ppk23+ neurons are required in the adult flies to directly transduce PGN signal, Gr66a+ neurons must be functional in larvae to allow future adults to become PGN sensitive. Furthermore, the ability of adult flies to respond to bacterial PGN is lost when they hatch from larvae reared under axenic conditions. Recolonization of germ-free larvae, but not adults, with a single bacterial species, <i>Lactobacillus brevis,</i> is sufficient to restore the ability of adults to respond to PGN. Our data demonstrate that the genetic and environmental characteristics of the larvae are essential to make the future adults competent to respond to certain sensory stimuli such as PGN.
DOI: 10.6084/m9.figshare.24058149.v1
title: Supplementary Cryo-TEM images

description: Supplementary images of Cryo-TEM analysis of <i>Bacteroides thetaiotaomicron </i>bacterial extracellular vesicles produced at different timepoints.
DOI: 10.6084/m9.figshare.24058149
title: Supplementary Cryo-TEM images

description: Supplementary images of Cryo-TEM analysis of <i>Bacteroides thetaiotaomicron </i>bacterial extracellular vesicles produced at different timepoints.
DOI: 10.21227/84gg-vv38
title: OESS+SESS in rail transit

description: The transition towards environmentally friendly transportation solutions has prompted a focused exploration of energy saving technologies within railway transit systems. Energy Storage Systems (ESS) in railway transit for Regenerative Braking Energy (RBE) recovery has gained prominence in the pursuit of sustainable transportation solutions. In order to achieve the dual-objective optimization of energy saving and investment, this paper proposes collaborative operation of Onboard Energy Storage Systems (OESS) and Stationary Energy Storage Systems (SESS). In the meantime, to optimize the ESS capacity and reduce its redundancy, Non-dominated Sorting Genetic Algorithm-II (NSGA-II) is applied. The simulation is programmed in MATLAB. The results show that the corporation of OESS and SESS is more superior than the case that only apply SESS in energy saving. Moreover, the OESS takes the significant role. The findings contribute to the ongoing efforts in developing more sustainable and energy-efficient transportation solutions, with implications for the railway industry and broader initiatives in sustainable urban mobility.
DOI: 10.21227/6ssx-ft56
title: CRPs Dataset of Ring Oscillator PUF

description: Physically unclonable functions (PUFs) are foundational components that offer a cost-efficient and promising solution for diverse security applications, including countering integrated circuit (IC) counterfeiting, generating secret keys, and enabling lightweight authentication. PUFs exploit semiconductor variations in ICs to derive inherent responses from imposed challenges, creating unique challenge-response pairs (CRPs) for individual devices. Analyzing PUF security is pivotal for identifying device vulnerabilities and ensuring response credibility. Consequently, CRP-centered scrutiny significantly shapes the block's resilience against general and modeling-based attacks. However, an updated and representative dataset is necessary for this analysis, as benchmark datasets evaluating PUF device efficacy and resilience are currently lacking. This study addresses this gap by producing a dataset of 300K CRPs for a digital PUF realized on a field-programmable gate array (FPGA). This dataset supplies a substantial quantity of CRPs for multi-bit responses, implicitly incorporating spatial and temporal relationships within the extracted CRPs.
DOI: 10.5281/zenodo.10477887
title: Enhancement of Transdermal Permeability of drug by Formulation of Novel Dosage Form

description: Topical drug delivery systems significantly improve the therapeutic efficacy of drugs. Drug-release-retarding polymers are the key performers in such systems. The topical route of drug delivery is the most preferred route for administration of drugs. The rationale for the development of an emulgel formulation of a drug is to enhance its therapeutic benefits, minimizing its side effect while improving the management of the diseased condition. Psoriasis is an immune disease caused by rapid and incomplete differentiation of skin basal cells. Natural products such as Indirubin have historically served as excellent sources for the treatments of psoriasis. Indirubin, isolated from indigo naturalis, has been shown to improve psorias is without causing any serious adverse events. The aim of the research was to develop and characterize emulgel formulations for Indirubin using different penetration enhancers identified and enhanced transdermal permeability. The drug content was found to be in the range of 81.13 – 98.25 %.From the in-vitro drug release data; it was observed that the percentage cumulative drug release of Indirubin was shown by formulation F3. F3 released 99.37 % of the drug in 60 min. The ‘n’ value of optimized formulation F3 was found to be 0.717 which indicated that the drug was released by first order kinetics with anomalous (Non-Fickian) release. From the stability studies, formulation F3 doesn’t show significant difference for physical properties, homogeneity, consistency, drug content and viscosity. Based on the above evaluation studies, it could be concluded that Indirubin can be used as an emulgel by mixing equal quantities of a gel and emulsion portions for acute bacterial skin infection.
DOI: 10.5281/zenodo.10477888
title: Enhancement of Transdermal Permeability of drug by Formulation of Novel Dosage Form

description: Topical drug delivery systems significantly improve the therapeutic efficacy of drugs. Drug-release-retarding polymers are the key performers in such systems. The topical route of drug delivery is the most preferred route for administration of drugs. The rationale for the development of an emulgel formulation of a drug is to enhance its therapeutic benefits, minimizing its side effect while improving the management of the diseased condition. Psoriasis is an immune disease caused by rapid and incomplete differentiation of skin basal cells. Natural products such as Indirubin have historically served as excellent sources for the treatments of psoriasis. Indirubin, isolated from indigo naturalis, has been shown to improve psorias is without causing any serious adverse events. The aim of the research was to develop and characterize emulgel formulations for Indirubin using different penetration enhancers identified and enhanced transdermal permeability. The drug content was found to be in the range of 81.13 – 98.25 %.From the in-vitro drug release data; it was observed that the percentage cumulative drug release of Indirubin was shown by formulation F3. F3 released 99.37 % of the drug in 60 min. The ‘n’ value of optimized formulation F3 was found to be 0.717 which indicated that the drug was released by first order kinetics with anomalous (Non-Fickian) release. From the stability studies, formulation F3 doesn’t show significant difference for physical properties, homogeneity, consistency, drug content and viscosity. Based on the above evaluation studies, it could be concluded that Indirubin can be used as an emulgel by mixing equal quantities of a gel and emulsion portions for acute bacterial skin infection.
DOI: 10.5281/zenodo.10259314
title: Offshore wind power curves

description: Offshore wind power profiles dataset based on the DTU study performed for the NSWPH.

Datasets are available in the following format: wrfts_[country_code]_[turbine_capacity_MW]_[energy_density_MW]_[status].csv. The countries in the dataset are BE, FR, NL, UK, DE, DK, NO. The statusses for each wind area are installed, planned, or available.

For the status installed, the turbine capacity is assumed 4 MW, and the energy density is a given - hence the classification real.

For the status planned, the turbine capacity is assumed 8 MW, and the energy density is also a given - hence the classification real. 

For the status available, the turbine capacity is assumed 15 MW, and the energy density is assumed to be either 4 MW/km2 or 8 MW/km2.

Geographical information for each wind area, along with the information available in the .csv files, are given in the shapefile ZIP folder.

Availability of offshore area for wind has been assessed in this study for extreme situations: only the areas currently designated as shipping lane or international environmental protection are considered as not available in this study. Therefore, the wind farm scenarios created for this study are extreme in number and extent, especially for the offshore regions of Northern Great Britain and Norway. These are fabricated scenarios and do not represent the actual government plans for wind farm deployment in the North Sea.
DOI: 10.5281/zenodo.10259315
title: Offshore wind power curves

description: Offshore wind power profiles dataset based on the DTU study performed for the NSWPH.

Datasets are available in the following format: wrfts_[country_code]_[turbine_capacity_MW]_[energy_density_MW]_[status].csv. The countries in the dataset are BE, FR, NL, UK, DE, DK, NO. The statusses for each wind area are installed, planned, or available.

For the status installed, the turbine capacity is assumed 4 MW, and the energy density is a given - hence the classification real.

For the status planned, the turbine capacity is assumed 8 MW, and the energy density is also a given - hence the classification real. 

For the status available, the turbine capacity is assumed 15 MW, and the energy density is assumed to be either 4 MW/km2 or 8 MW/km2.

Geographical information for each wind area, along with the information available in the .csv files, are given in the shapefile ZIP folder.

Availability of offshore area for wind has been assessed in this study for extreme situations: only the areas currently designated as shipping lane or international environmental protection are considered as not available in this study. Therefore, the wind farm scenarios created for this study are extreme in number and extent, especially for the offshore regions of Northern Great Britain and Norway. These are fabricated scenarios and do not represent the actual government plans for wind farm deployment in the North Sea.
DOI: 10.15470/walyve
title: Cat?logo flor?stico de la cantera de Yepes-Ciruelos (Holcim Espa?a)

description: La cantera de Yepes-Ciruelos se encuentra en el sector Manchego bajo bioclima mesomediterr?neo superior y ombroclima seco inferior. Se trata de una cantera a cielo abierto para la extracci?n de caliza perteneciente al grupo Holcim. La Universidad de Castilla-La Mancha se ha encargado del seguimiento de las labores de restauraci?n en el contexto de un convenio de colaboraci?n con la empresa desde el a?o 2003. Los objetivos a alcanzar se establecieron tras el estudio previo de la flora y vegetaci?n de la cantera y del entorno de la Mesa de Oca?a y la priorizaci?n de especies y h?bitats a restaurar. A partir de estos datos se pueden identificar los 'cuellos de botella' para actuar sobre ellos y acelerar el proceso de sucesi?n secundaria. En ecosistemas ?ridos el proceso de sucesi?n secundaria es lento, esto es debido a que la germinaci?n y sobre todo el reclutamiento de nuevos individuos dependen de los fen?menos de precipitaci?n, a este factor se le debe sumar la ocurrencia de heladas y la herbivor?a. Los factores mencionados son extrapolables al ?xito de las labores de restauraci?n, por lo tanto, cometer errores puede significar una p?rdida alta de recursos y tiempo; para garantizar el ?xito de la restauraci?n es fundamental la aplicaci?n de las t?cnicas adecuadas. La intervenci?n en las zonas objetivo mediante acciones de restauraci?n fundamentadas en Soluciones Basadas en la Naturaleza, permite la asistencia a la recuperaci?n de ecosistemas as? como la promoci?n y apoyo de los procesos de sucesi?n secundaria en la cantera. El ?xito se alcanza cuando se puede observar que los individuos introducidos cierran su ciclo biol?gico, dando lugar a nuevos individuos que se integran en los procesos de sucesi?n vegetal.
DOI: 10.5285/0c3f44e7-8db9-04d5-e063-6c86abc0bc23
title: Hydrographic section data (dissolved inorganic nutrients, dissolved inorganic carbon and total alkalinity) from DY078, May 2017, from the Eastern Boundary array (Rockall Trough), as part of UK OSNAP (Overturning in the Subpolar North Atlantic Programme).

description: The dataset consists of water samples collected in the Rockall Trough along the Extended Ellett Line using the lowered rosette during cruise DY078 in May 2017. Samples were analysed for dissolved inorganic carbon, total alkalinity, nitrite+nitrate, phosphate, and silicate. The cruise took place under UK OSNAP (NE/K010875/1 and NE/K010875/2) and UK National Capability CLASS (NE/R015953/1). Sample analysis was funded by the European Union's Horizon 2020 Research and Innovation Programme under grant agreement no. 678760 (ATLAS).
DOI: 10.5281/zenodo.8143309
title: The Potential Role of SARS-CoV-2 Infection and Vaccines in Multiple Sclerosis Onset and Reactivation: A Case Series and Literature Review

description: Introduction


This database includes the raw data linked with the paper “ The Potential Role of SARS-CoV-2 Infection and Vaccines in Multiple Sclerosis Onset and Reactivation: A Case Series and Literature Review  ” published on “Viruses”.


In this paper, we reported clinical and MRI features of 12 MS cases/myelitis onset or reactivation after SARS-CoV-2/related vaccine exposure during


Methods


This is a case series of 11 cases of multiple sclerosis onset/reactivation after viral/vaccine exposure and 1 case of myelitis reactivation after SARS-CoV-2 vaccines. Clinical and MRI data were collected from clinical charts of patients that have been evaluated at our Institute


Results (in brief)


All the cases share a temporal association between viral/vaccine exposure and symptoms onset. This finding, together with direct or immune-based mechanisms described both during COVID-19 and MS, claims in favor of a role for SARS-CoV-2 infection/vaccines in unmasking dysimmune CNS disorders. The most common clinical presentations involve the optic nerve, brainstem and spinal cord.
DOI: 10.5281/zenodo.8143310
title: The Potential Role of SARS-CoV-2 Infection and Vaccines in Multiple Sclerosis Onset and Reactivation: A Case Series and Literature Review

description: Introduction


This database includes the raw data linked with the paper “ The Potential Role of SARS-CoV-2 Infection and Vaccines in Multiple Sclerosis Onset and Reactivation: A Case Series and Literature Review  ” published on “Viruses”.


In this paper, we reported clinical and MRI features of 12 MS cases/myelitis onset or reactivation after SARS-CoV-2/related vaccine exposure during


Methods


This is a case series of 11 cases of multiple sclerosis onset/reactivation after viral/vaccine exposure and 1 case of myelitis reactivation after SARS-CoV-2 vaccines. Clinical and MRI data were collected from clinical charts of patients that have been evaluated at our Institute


Results (in brief)


All the cases share a temporal association between viral/vaccine exposure and symptoms onset. This finding, together with direct or immune-based mechanisms described both during COVID-19 and MS, claims in favor of a role for SARS-CoV-2 infection/vaccines in unmasking dysimmune CNS disorders. The most common clinical presentations involve the optic nerve, brainstem and spinal cord.
DOI: 10.5281/zenodo.7347713
title: A common NFKB1 variant detected through antibody analysis in UK Biobank predicts risk of infection and allergy: Summary statistics - Serology

description: Infectious agents contribute significantly to the global burden of diseases, through both acute infection and their chronic sequelae. We leveraged the UK Biobank to identify genetic loci that influence humoral immune response to multiple infections. From 45 genome-wide association studies in 9,611 participants from UK Biobank, we identified NFKB1 as a locus associated with quantitative antibody responses to multiple pathogens including those from the herpes, retro- and polyoma-virus families. An insertion-deletion variant thought to affect NFKB1 expression (rs28362491), was mapped as the likely causal variant. This variant has persisted throughout hominid evolution and could play a key role in regulation of the immune response. Using 121 infection and inflammation related traits in 487,297 UK Biobank participants, we show that the deletion allele was associated with an increased risk of infection from diverse pathogens but had a protective effect against allergic disease. We propose that altered expression of NFKB1, as a result of the deletion, modulates haematopoietic pathways, and likely impacts cell survival, antibody production, and inflammation. Taken together, we show that disruptions to the tightly regulated immune processes may tip the balance between exacerbated immune responses and allergy, or increased risk of infection and impaired resolution of inflammation. 


-------------------------------------------------------------------------------------


This dataset contains GWAS summary statistics for quantitative antibody responses in 9611 individuals and results for a meta-analysis of UK Biobank and CoLaus/PsyCoLaus antibody responses.
DOI: 10.5281/zenodo.7347714
title: A common NFKB1 variant detected through antibody analysis in UK Biobank predicts risk of infection and allergy: Summary statistics - Serology

description: Infectious agents contribute significantly to the global burden of diseases, through both acute infection and their chronic sequelae. We leveraged the UK Biobank to identify genetic loci that influence humoral immune response to multiple infections. From 45 genome-wide association studies in 9,611 participants from UK Biobank, we identified NFKB1 as a locus associated with quantitative antibody responses to multiple pathogens including those from the herpes, retro- and polyoma-virus families. An insertion-deletion variant thought to affect NFKB1 expression (rs28362491), was mapped as the likely causal variant. This variant has persisted throughout hominid evolution and could play a key role in regulation of the immune response. Using 121 infection and inflammation related traits in 487,297 UK Biobank participants, we show that the deletion allele was associated with an increased risk of infection from diverse pathogens but had a protective effect against allergic disease. We propose that altered expression of NFKB1, as a result of the deletion, modulates haematopoietic pathways, and likely impacts cell survival, antibody production, and inflammation. Taken together, we show that disruptions to the tightly regulated immune processes may tip the balance between exacerbated immune responses and allergy, or increased risk of infection and impaired resolution of inflammation. 


-------------------------------------------------------------------------------------


This dataset contains GWAS summary statistics for quantitative antibody responses in 9611 individuals and results for a meta-analysis of UK Biobank and CoLaus/PsyCoLaus antibody responses.
DOI: 10.5281/zenodo.7347791
title: A common NFKB1 variant detected through antibody analysis in UK Biobank predicts risk of infection and allergy: Summary statistics - Health records

description: Infectious agents contribute significantly to the global burden of diseases, through both acute infection and their chronic sequelae. We leveraged the UK Biobank to identify genetic loci that influence humoral immune response to multiple infections. From 45 genome-wide association studies in 9,611 participants from UK Biobank, we identified NFKB1 as a locus associated with quantitative antibody responses to multiple pathogens including those from the herpes, retro- and polyoma-virus families. An insertion-deletion variant thought to affect NFKB1 expression (rs28362491), was mapped as the likely causal variant. This variant has persisted throughout hominid evolution and could play a key role in regulation of the immune response. Using 121 infection and inflammation related traits in 487,297 UK Biobank participants, we show that the deletion allele was associated with an increased risk of infection from diverse pathogens but had a protective effect against allergic disease. We propose that altered expression of NFKB1, as a result of the deletion, modulates haematopoietic pathways, and likely impacts cell survival, antibody production, and inflammation. Taken together, we show that disruptions to the tightly regulated immune processes may tip the balance between exacerbated immune responses and allergy, or increased risk of infection and impaired resolution of inflammation. 


-------------------------------------------------------------------------------------


This dataset contains GWAS summary statistics for infection, inflammation, and allergy related traits in 487,297 individuals
DOI: 10.35078/wxw6hp/ztf9a1
title: Pedra Grande B.jpg

description: :unav
DOI: 10.35078/e2opto/qvfwwe
title: Trombeta D.jpg

description: :unav
DOI: 10.35078/4yrc1c/2qkcye
title: Córrego Pouso Alegre D.jpg

description: :unav
DOI: 10.35078/e2opto/dxiu5t
title: Derrama F.jpg

description: :unav
DOI: 10.35078/wxw6hp/hje96t
title: Mangabeira A.jpg

description: :unav
DOI: 10.35078/4yrc1c/jmzzu5
title: Capelinha São João Pov. E.jpg

description: :unav
DOI: 10.35078/e2opto/aivwgk
title: Fábrica B.jpg

description: :unav
DOI: 10.35078/wxw6hp/9ifkzq
title: José Carneiro Filho A.jpg

description: :unav
DOI: 10.35078/4yrc1c/ya9bqf
title: Lavapés E.jpg

description: :unav
DOI: 10.35078/e2opto/wrponw
title: Santo Inácio II D.jpg

description: :unav
DOI: 10.35078/4yrc1c/7haoh9
title: Matinha B.jpg

description: :unav
DOI: 10.35078/wxw6hp/pv8xma
title: Estreito E.jpg

description: :unav
DOI: 10.35078/4yrc1c/16qfxw
title: Mata C.jpg

description: :unav
DOI: 10.35078/e2opto/w0f1kx
title: Santo Inácio de Cima E.jpg

description: :unav
DOI: 10.35078/wxw6hp/ilzl73
title: Pai Joaquim Usina C.jpg

description: :unav
DOI: 10.35078/e2opto/y85tpc
title: Capetinga I C.jpg

description: :unav
DOI: 10.35078/wxw6hp/m9cfor
title: Pedro Vicente de Faria B.jpg

description: :unav
DOI: 10.35078/4yrc1c/drgyxh
title: Olhos d'Água II B.jpg

description: :unav
DOI: 10.35078/e2opto/yowdkg
title: Vereda I D.jpg

description: :unav
DOI: 10.35078/4yrc1c/uz7twf
title: Baia C.jpg

description: :unav
DOI: 10.35078/wxw6hp/zznetn
title: Ponta Grande A.jpg

description: :unav
DOI: 10.35078/e2opto/lysicb
title: Palmito B.jpg

description: :unav
DOI: 10.35078/4yrc1c/c3a3ok
title: Pouso Alegre F.jpg

description: :unav
DOI: 10.35078/wxw6hp/qpxeo0
title: José Gomes Santos D.jpg

description: :unav
DOI: 10.35078/e2opto/oy8hir
title: Gameleira A.jpg

description: :unav
DOI: 10.35078/wxw6hp/h6iwcq
title: Jerônimo Borges B.jpg

description: :unav
DOI: 10.35078/4yrc1c/lpknvg
title: Capelinha São João Pov. F.jpg

description: :unav
DOI: 10.35078/wxw6hp/tvkio5
title: Orlando Damasceno A.jpg

description: :unav
DOI: 10.35078/e2opto/qzj23d
title: Morro Alto E.jpg

description: :unav
DOI: 10.35078/4yrc1c/vw8wp2
title: Olhos d'Água IV F.jpg

description: :unav
DOI: 10.35078/e2opto/qdzkpt
title: Campestre A.jpg

description: :unav
DOI: 10.35078/4yrc1c/87ozll
title: São João III C.jpg

description: :unav