cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.6395984.v3
title: Full dataset

description: <b>Background:</b> The World Health Organization recommends isoniazid preventive therapy (IPT) for six months for child contacts without tuberculosis (TB), who are exposed to an adult with active TB. The effectiveness of IPT depends on 80% or greater adherence to medication. In the current study, we assessed IPT adherence and explored barriers to and facilitators of adherence among eligible child contacts in Kigali, Rwanda. <b>Methods</b>: A mixed method study design was used to prospectively assess adherence to IPT among eligible child contacts and its associated factors through a quantitative, observational cohort study, and to explore barriers to and facilitators of adherence to IPT through a descriptive qualitative study. <b>Results</b>: Of the 84 child contacts who started IPT, 74 (88%) had complete adherence and ten (12%) incomplete adherence. There were no factors (individual characteristics of index cases, households and or health facility characteristics) found to be significantly associated with IPT adherence in the bivariate and multivariate analysis. In the qualitative analysis, we identified factors relating to parents/caregivers, disease, household and health-care providers as major themes determining IPT adherence. <b>Conclusion</b>:<b> </b>There was a high rate of IPT completion in this cohort of eligible child contacts living in Kigali. However, structural factors (poverty and relocation) were found to be the main barriers to IPT adherence that could be addressed by health-care providers. <br>
DOI: 10.6084/m9.figshare.6395984.v2
title: S1_Data_quantitative study.xlsx

description: Background: World Health Organisation (WHO) recommends Isoniazid Preventive Therapy (IPT) for six months to child contacts without tuberculosis (TB). Child contacts are defined as children under 15 years old who are exposed to an adult with active TB. The effectiveness of IPT depends on medication adherence of 80% or greater. The current study assessed IPT adherence and explored barriers to adherence ineligible child TB contacts in Rwanda.<br>Methods: A mixed method study design was used to prospectively assess adherence to IPT among eligible child contacts and its associated factors through a quantitative, observational cohort study, and to explore barriers and facilitators of adherence to IPT through a qualitative study.<br>Results: Among the 270 child contacts recruited for the main cross-sectional study, 94 (35%) were under 5 years old and eligible for IPT. Eighty-four (89%) started IPT, but 10 (12%) of them did not complete 6 months of IPT. Only one child contact developed TB after IPT completion. There were no factors found to be significantly associated with IPT adherence in a bivariate and multivariate analysis. The qualitative analysis shows that parents/caregivers, household, diseases, health care providers, child-related factors and access are the major sub-themes determining IPT adherence.<br>Conclusion: This study shows that whereas IPT is well managed in Rwanda, barriers to IPT adherence remain, and strategies are needed to address challenges with IPT adherence as part of the National Tuberculosis Programme.
DOI: 10.6084/m9.figshare.6395978
title: Supplementary Material for: Association of Monocyte Chemoattractant Protein-1 with Death and Atherosclerotic Events in Chronic Kidney Disease

description: <b><i>Background:</i></b> Monocyte chemoattractant protein-1 ­(MCP-1), a marker of inflammation and monocyte recruitment to atherosclerotic plaques, is associated with cardiovascular (CV) outcomes in patients with acute coronary syndrome. Although plasma levels are elevated in chronic kidney disease (CKD), associations with reduced kidney function or outcomes in CKD have not been explored. <b><i>Methods:</i></b> In this population-based, probability-sampled, longitudinal cohort of 3,257 participants, including 286 (8.8%) patients with CKD, we studied the association of plasma MCP-1 with estimated glomerular filtration rate (eGFR), albuminuria, death, and intermediate and hard CV outcomes in CKD and non-CKD individuals. Cox proportional hazards regression assessed associations of baseline MCP-1 with all-cause death and atherosclerotic events. <b><i>Results:</i></b> MCP-1 was higher in CKD than non-CKD participants (<i>p</i> &lt; 0.001), and negatively associated with eGFR (<i>r</i> = –0.23, <i>p</i> &lt; 0.0001) but not albuminuria in CKD. MCP-1 was associated with pulse wave velocity and coronary artery calcification in non-CKD but not CKD individuals. At 13.5 years, there were 230 (7.7%) deaths and 168 (6.4%) atherosclerotic events in the non-CKD vs. 97 (34.0%) deaths and 62 (27.9%) events in the CKD group (<i>p</i> &lt; 0.001 for each). MCP-1 was associated with death (hazards ratio [HR] 2.0 [1.4–2.9] per log-unit increase) and atherosclerotic events (1.7 [1.0–2.9]) in CKD individuals. The HR for death in CKD remained significant (1.6 [1.1–2.3]) after adjusting for CV risk factors. <b><i>Conclusions:</i></b> Although plasma MCP-1 increased with decreased eGFR, it remained an independent risk factor for death in CKD. MCP-1 did not correlate with intermediate CV outcomes, implicating pathways other than atherosclerosis in the association of MCP-1 with death in CKD.
DOI: 10.6084/m9.figshare.6395975
title: data

description: phrase pairs and precomputed features<br>
DOI: 10.6084/m9.figshare.6395975.v1
title: data

description: phrase pairs and precomputed features<br>
DOI: 10.6084/m9.figshare.6395840
title: Curry-Jet SETUP

description: The "curry-jet" is a jet spectrometer setup combining spontaneous Raman scattering with a supersonic jet expansion. <br><br>The carrier gas (typically helium) is enriched by the desired substance in either a cryostatically cooled (S1) or a heated (S2) saturator system, depending on the vapor pressure and the desired concentration.The mixture is supersonically expanded through a heatabe slit nozzle (N) from 0.1-1.3 bar stagnation pressure into the vacuum chamber at ca 1 mbar background pressure. A continuous operation is ensured by roots and rotary vane backing pumps in series with a maximum pumping speed of ca. 500 m<sup>3</sup>/h.The expansion is probed 1-3 mm downstream the nozzle by a focussed (L1) 532 nm cw laser (Spectra Physics Millennia eV) with a maximum output of 25 W.The scattered light is collected in a 90° angle with a standard 50 mm photo objective (O) as a collimator and focussed outside the chamber onto a 1000 mm monochromator with a 1340x400 px L-N<sub>2</sub> cooled CCD detector (Princeton Pylon 400 B) attached to it.This Raman spectrometer is used under non-resonant conditions and the good signal-to-noise ratio is accomplished by long integration times up to 10 minutes and averaging of multiple spectra.Calibration is done with krypton and neon calibration lamps through the pinhole (PH).<br>Cosmic ray removal is achived by a script-based pixel-to-pixel comparison of multiple spectra.<br>The setup is under constant improvement, thus the presented scheme applies to group research from 2015 to 2018. Selected publications are mentioned below, for a more complete record, see: https://hbond.uni-goettingen.de/publicat.html<br>(abbreviations used in the english version: BP - bypass, BS - beam stop, CV - check valve, EF - edge filter, L - focus lens, M - laser mirror, N - nozzle, O - objective, P - pressure gauge, PH - pinhole, S - saturator, SV - solenoid valve, W - window)<br>
DOI: 10.6084/m9.figshare.6395831
title: Supplemental Material for Yamakawa et al., 2018

description: This file contains all supplemental figures, tables and reagent table of "Insight into Notch Signaling Steps that Involve <i>pecanex</i> from Dominant-Modifier Screens in <i>Drosophila</i>, Yamakawa et al., 2018". Figure S1-S8 describes the mapping on identification of <i>pecanex</i> modifier loci. Table S1 and S2 contains the lists of all <i>D. melanogaster</i> strains used for this screen.
DOI: 10.6084/m9.figshare.6395831.v1
title: Supplemental Material for Yamakawa et al., 2018

description: This file contains all supplemental figures, tables and reagent table of "Insight into Notch Signaling Steps that Involve <i>pecanex</i> from Dominant-Modifier Screens in <i>Drosophila</i>, Yamakawa et al., 2018". Figure S1-S8 describes the mapping on identification of <i>pecanex</i> modifier loci. Table S1 and S2 contains the lists of all <i>D. melanogaster</i> strains used for this screen.
DOI: 10.6084/m9.figshare.6395822
title: A proposed underlying source of human error

description: Difficult tasks tend to increase response times and errors, but also, paradoxically, the more quickly we have to respond to something, the more likely it is that we will make an error. Although much-researched and discussed, the underlying reasons for these apparent connections and contradictions have never been satisfactorily explained. This paper proposes that cognitive information is processed in discrete packages so that, during decision making, the likelihood and type of error depends on the precise moment at which a decision is taken and the degree to which the decision is synchronous with package processing. By understanding how response times and error might be connected, we can make informed judgements about how one might affect the other. This offers the prospect of reducing human error, which is particularly important in safety critical environments, but which also has application for improving reliability across all human activity.
DOI: 10.6084/m9.figshare.6395822.v2
title: A proposed underlying source of human error

description: Difficult tasks tend to increase response times and errors, but also, paradoxically, the more quickly we have to respond to something, the more likely it is that we will make an error. Although much-researched and discussed, the underlying reasons for these apparent connections and contradictions have never been satisfactorily explained. This paper proposes that cognitive information is processed in discrete packages so that, during decision making, the likelihood and type of error depends on the precise moment at which a decision is taken and the degree to which the decision is synchronous with package processing. By understanding how response times and error might be connected, we can make informed judgements about how one might affect the other. This offers the prospect of reducing human error, which is particularly important in safety critical environments, but which also has application for improving reliability across all human activity.
DOI: 10.6084/m9.figshare.6395774
title: Tongxinluo attenuates reperfusion injury-Kang Qi-PLOSone

description: PLOSone
DOI: 10.6084/m9.figshare.6395774.v1
title: Tongxinluo attenuates reperfusion injury-Kang Qi-PLOSone

description: PLOSone
DOI: 10.6084/m9.figshare.6395750
title: MOESM4 of Comparative transcriptomics of choroid plexus in Alzheimer’s disease, frontotemporal dementia and Huntington’s disease: implications for CSF homeostasis

description: Additional file 4: Table S4. The top 10 most upregulated and top 10 most downregulated genes in the AD vs. Ctrl comparison, with p
DOI: 10.6084/m9.figshare.6395750.v1
title: MOESM4 of Comparative transcriptomics of choroid plexus in Alzheimer’s disease, frontotemporal dementia and Huntington’s disease: implications for CSF homeostasis

description: Additional file 4: Table S4. The top 10 most upregulated and top 10 most downregulated genes in the AD vs. Ctrl comparison, with p
DOI: 10.6084/m9.figshare.6395741
title: Additional file 1: of A targeted in situ hybridization screen identifies putative seminal fluid proteins in a simultaneously hermaphroditic flatworm

description: Figure S1-S3. Whole-mount in situ hybridization expression patterns found for transcripts in Macrostomum lignano that are both phenotypically plastic (sensu ‘social’ RNA-Seq) and tail-limited (sensu ‘positional’ RNA-Seq). Of the 146 transcripts investigated, we obtained tissue-specific expression patterns that can be divided into three categories, namely (Figure S1.) prostate-limited expression; (Figure S2.) prostate-specific expression coupled with tissue-specific expression elsewhere in the worm; and (Figure S3.) tissue-specific expression that did not include the prostate. The expression patterns of 10 transcripts could not be established. Within each category, pictures are arranged (from top-left to bottom-right) in descending order of fold-change in expression in octets versus isolated worms. One representative picture per transcript is included. (ZIP 5699 kb)
DOI: 10.6084/m9.figshare.6395741.v1
title: Additional file 1: of A targeted in situ hybridization screen identifies putative seminal fluid proteins in a simultaneously hermaphroditic flatworm

description: Figure S1-S3. Whole-mount in situ hybridization expression patterns found for transcripts in Macrostomum lignano that are both phenotypically plastic (sensu ‘social’ RNA-Seq) and tail-limited (sensu ‘positional’ RNA-Seq). Of the 146 transcripts investigated, we obtained tissue-specific expression patterns that can be divided into three categories, namely (Figure S1.) prostate-limited expression; (Figure S2.) prostate-specific expression coupled with tissue-specific expression elsewhere in the worm; and (Figure S3.) tissue-specific expression that did not include the prostate. The expression patterns of 10 transcripts could not be established. Within each category, pictures are arranged (from top-left to bottom-right) in descending order of fold-change in expression in octets versus isolated worms. One representative picture per transcript is included. (ZIP 5699 kb)
DOI: 10.6084/m9.figshare.6395738
title: MOESM3 of Comparative transcriptomics of choroid plexus in Alzheimer’s disease, frontotemporal dementia and Huntington’s disease: implications for CSF homeostasis

description: Additional file 3: Table S3. Geneset Annotations: Worksheets contain pathways enriched among genes upregulated in AD vs. Ctrl (S3a); downregulated in AD vs. Ctrl (S3b); upregulated in AD but not in HuD + FTD vs. Ctrl (S3c); and upregulated in HuD + FTD but not AD vs. Ctrl (S3d). Hypergeometric p-values (p-value), Bonferroni-corrected p-values (E-value), overlaps and input and background set sizes are provided.
DOI: 10.6084/m9.figshare.6395738.v1
title: MOESM3 of Comparative transcriptomics of choroid plexus in Alzheimer’s disease, frontotemporal dementia and Huntington’s disease: implications for CSF homeostasis

description: Additional file 3: Table S3. Geneset Annotations: Worksheets contain pathways enriched among genes upregulated in AD vs. Ctrl (S3a); downregulated in AD vs. Ctrl (S3b); upregulated in AD but not in HuD + FTD vs. Ctrl (S3c); and upregulated in HuD + FTD but not AD vs. Ctrl (S3d). Hypergeometric p-values (p-value), Bonferroni-corrected p-values (E-value), overlaps and input and background set sizes are provided.
DOI: 10.6084/m9.figshare.6395729
title: Additional file 2: of Energetic evolution of cellular Transportomes

description: Data S1. Genomic and transportome data on the organisms included in the study. (XLSX 255Â kb)
DOI: 10.6084/m9.figshare.6395729.v1
title: Additional file 2: of Energetic evolution of cellular Transportomes

description: Data S1. Genomic and transportome data on the organisms included in the study. (XLSX 255Â kb)
DOI: 10.6084/m9.figshare.6395723
title: MOESM2 of Comparative transcriptomics of choroid plexus in Alzheimer’s disease, frontotemporal dementia and Huntington’s disease: implications for CSF homeostasis

description: Additional file 2: Table S2. T-test results for choroid plexus RNA from 6 control, 7 Alzheimer’s disease, 4 FTD and 3HUD subjects: T-test p-values and expression differences (Log10 Disease/Ctrl) for each disease type are provided for all 5760 Affymetrix probesets measured. Values for the AD vs. HuD + FTD subject comparison are also provided.
DOI: 10.6084/m9.figshare.6395723.v1
title: MOESM2 of Comparative transcriptomics of choroid plexus in Alzheimer’s disease, frontotemporal dementia and Huntington’s disease: implications for CSF homeostasis

description: Additional file 2: Table S2. T-test results for choroid plexus RNA from 6 control, 7 Alzheimer’s disease, 4 FTD and 3HUD subjects: T-test p-values and expression differences (Log10 Disease/Ctrl) for each disease type are provided for all 5760 Affymetrix probesets measured. Values for the AD vs. HuD + FTD subject comparison are also provided.
DOI: 10.6084/m9.figshare.6395705
title: MOESM1 of Comparative transcriptomics of choroid plexus in Alzheimer’s disease, frontotemporal dementia and Huntington’s disease: implications for CSF homeostasis

description: Additional file 1: Table S1. Sample Annotations and Patient Demographics: ‘QC passed’ indicates samples passing both RNA and Affymetrix quality control, and used for analysis. APOE; genotype data consist of combinations of the ε2, ε3 and ε4 alleles, with ε4 carrying the highest risk for brain injury; Bioanalyzer (BA); RNA Integrity (RIN).
DOI: 10.6084/m9.figshare.6395705.v1
title: MOESM1 of Comparative transcriptomics of choroid plexus in Alzheimer’s disease, frontotemporal dementia and Huntington’s disease: implications for CSF homeostasis

description: Additional file 1: Table S1. Sample Annotations and Patient Demographics: ‘QC passed’ indicates samples passing both RNA and Affymetrix quality control, and used for analysis. APOE; genotype data consist of combinations of the ε2, ε3 and ε4 alleles, with ε4 carrying the highest risk for brain injury; Bioanalyzer (BA); RNA Integrity (RIN).
DOI: 10.6084/m9.figshare.6395657
title: Additional file 8: of Silicon protects soybean plants against Phytophthora sojae by interfering with effector-receptor expression

description: Table S6. Expression data of WRKY transcription factor genes. Normalized mean (n = 5), fold-change and FDR p-value of 20 WRKY genes in soybean plants treated (Si+) or not (Si-) with silicon (Si) at 0, 4, 7, and 14 dpi with Phytophthora sojae. (XLSX 16 kb)
DOI: 10.6084/m9.figshare.6395657.v1
title: Additional file 8: of Silicon protects soybean plants against Phytophthora sojae by interfering with effector-receptor expression

description: Table S6. Expression data of WRKY transcription factor genes. Normalized mean (n = 5), fold-change and FDR p-value of 20 WRKY genes in soybean plants treated (Si+) or not (Si-) with silicon (Si) at 0, 4, 7, and 14 dpi with Phytophthora sojae. (XLSX 16 kb)
DOI: 10.6084/m9.figshare.6395630
title: Additional file 6: of Silicon protects soybean plants against Phytophthora sojae by interfering with effector-receptor expression

description: Table S5. Expression data of PR genes. Normalized mean (n = 5), fold-change and FDR p-value of 11 pathogenesis-related (PR) genes in soybean plants treated (Si+) or not (Si-) with silicon (Si) at 0, 4, 7, and 14 dpi with Phytophthora sojae. (XLSX 12 kb)
DOI: 10.6084/m9.figshare.6395630.v1
title: Additional file 6: of Silicon protects soybean plants against Phytophthora sojae by interfering with effector-receptor expression

description: Table S5. Expression data of PR genes. Normalized mean (n = 5), fold-change and FDR p-value of 11 pathogenesis-related (PR) genes in soybean plants treated (Si+) or not (Si-) with silicon (Si) at 0, 4, 7, and 14 dpi with Phytophthora sojae. (XLSX 12 kb)
DOI: 10.6084/m9.figshare.6395618
title: Additional file 5: of Silicon protects soybean plants against Phytophthora sojae by interfering with effector-receptor expression

description: Table S4. Expression data of NB-LRRs genes. Normalized mean (n = 5), fold-change and FDR p-value of 45 receptor (NB-LRR) genes in soybean plants treated (Si+) or not (Si-) with silicon (Si) at 0, 4, 7, and 14 dpi with Phytophthora sojae. (XLSX 22 kb)
DOI: 10.6084/m9.figshare.6395618.v1
title: Additional file 5: of Silicon protects soybean plants against Phytophthora sojae by interfering with effector-receptor expression

description: Table S4. Expression data of NB-LRRs genes. Normalized mean (n = 5), fold-change and FDR p-value of 45 receptor (NB-LRR) genes in soybean plants treated (Si+) or not (Si-) with silicon (Si) at 0, 4, 7, and 14 dpi with Phytophthora sojae. (XLSX 22 kb)
DOI: 10.6084/m9.figshare.6395600
title: Additional file 4: of Silicon protects soybean plants against Phytophthora sojae by interfering with effector-receptor expression

description: Table S3. Expression data of signaling-related genes. Normalized mean (n = 5), fold-change and FDR p-value of 46 receptor kinase family genes (sheet 1), 24 RLK genes (sheet 2), 5 MAPKs genes (sheet 3), and 33 CDPKs genes (sheet 4) in soybean plants treated (Si+) or not (Si-) with silicon (Si) at 0, 4, 7, and 14 dpi with Phytophthora sojae. (XLSX 65 kb)
DOI: 10.6084/m9.figshare.6395600.v1
title: Additional file 4: of Silicon protects soybean plants against Phytophthora sojae by interfering with effector-receptor expression

description: Table S3. Expression data of signaling-related genes. Normalized mean (n = 5), fold-change and FDR p-value of 46 receptor kinase family genes (sheet 1), 24 RLK genes (sheet 2), 5 MAPKs genes (sheet 3), and 33 CDPKs genes (sheet 4) in soybean plants treated (Si+) or not (Si-) with silicon (Si) at 0, 4, 7, and 14 dpi with Phytophthora sojae. (XLSX 65 kb)
DOI: 10.5281/zenodo.4007712
title: Dataset for "Impact of Dust Shortwave Absorbability on the East Asian Summer Monsoon"

description: Dataset for "Impact of Dust Shortwave Absorbability on the East Asian Summer Monsoon"
DOI: 10.6084/m9.figshare.6395588
title: Additional File 9:

description: Novel miRNA precursors sequences in fasta format. Fasta headers report the absolute genomic start position of the sequence or the ID of the similar miRNA for novel miRNA detected by similarity to other species (cow, sheep or horse). (TXT 30 kb)
DOI: 10.6084/m9.figshare.6395588.v1
title: Additional File 9:

description: Novel miRNA precursors sequences in fasta format. Fasta headers report the absolute genomic start position of the sequence or the ID of the similar miRNA for novel miRNA detected by similarity to other species (cow, sheep or horse). (TXT 30 kb)
DOI: 10.6084/m9.figshare.6395579
title: Additional file 2: of Silicon protects soybean plants against Phytophthora sojae by interfering with effector-receptor expression

description: Table S2. Normalized expression of differentially expressed genes in soybean roots infected with Phytophthora sojae. In total, 3294 genes were differentially expressed as a result of P. sojae infection at day 4 after inoculation (P+Si−). The normalized mean (n = 5) of the differentially expressed transcripts (Fold-change ≥4, FDR p-value ≤0.01) are presented in soybean roots inoculated (P+) or not (P−) with P. sojae and treated (Si+) or not (Si−) with silicon. (XLSB 215 kb)
DOI: 10.6084/m9.figshare.6395579.v1
title: Additional file 2: of Silicon protects soybean plants against Phytophthora sojae by interfering with effector-receptor expression

description: Table S2. Normalized expression of differentially expressed genes in soybean roots infected with Phytophthora sojae. In total, 3294 genes were differentially expressed as a result of P. sojae infection at day 4 after inoculation (P+Si−). The normalized mean (n = 5) of the differentially expressed transcripts (Fold-change ≥4, FDR p-value ≤0.01) are presented in soybean roots inoculated (P+) or not (P−) with P. sojae and treated (Si+) or not (Si−) with silicon. (XLSB 215 kb)
DOI: 10.6084/m9.figshare.6395573
title: Additional File 8:

description: Novel miRNA mature sequences in fasta format. Fasta headers report the absolute genomic start position of the sequence or the ID of the similar miRNA for novel miRNA detected by similarity to other species (cow, sheep or horse). (TXT 16 kb)
DOI: 10.6084/m9.figshare.6395573.v1
title: Additional File 8:

description: Novel miRNA mature sequences in fasta format. Fasta headers report the absolute genomic start position of the sequence or the ID of the similar miRNA for novel miRNA detected by similarity to other species (cow, sheep or horse). (TXT 16 kb)