cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.5517/ccdc.csd.cc2fvpxx
title: CCDC 2259990: Experimental Crystal Structure Determination

description: Related Article: Ze-Bei Xie, Tian-Cai Yue, Qing-Wei Dong, Qi-Chao Ma, Qing-Wei Cao, Lu-Lu Wang, Duo-Zhi Wang|2024|Polyhedron|249|116777|doi:10.1016/j.poly.2023.116777
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.6084/m9.figshare.25027232
title: Contigs

description: Genome assemblies for the Campylobacter genomes sequenced for this study and chicken-associated Campylobacter genomes used as a context collection
DOI: 10.5281/zenodo.10533108
title: Link to dataset related to article "Single-Cell RNA Sequencing Reveals Metabolic Stress-Dependent Activation of Cardiac Macrophages in a Model of Dyslipidemia-Induced Diastolic Dysfunction "

description: This record contains link to raw data related to article “Single-Cell RNA Sequencing Reveals Metabolic Stress-Dependent Activation of Cardiac Macrophages in a Model of Dyslipidemia-Induced Diastolic Dysfunction"

Abstract



 Background:  Metabolic distress is often associated with heart failure with preserved ejection fraction (HFpEF) and represents a therapeutic challenge. Metabolism-induced systemic inflammation links comorbidities with HFpEF. How metabolic changes affect myocardial inflammation in the context of HFpEF is not known.

 Methods:  We found that ApoE knockout mice fed a Western diet recapitulate many features of HFpEF. Single-cell RNA sequencing was used for expression analysis of CD45+ cardiac cells to evaluate the involvement of inflammation in diastolic dysfunction. We focused bioinformatics analysis on macrophages, obtaining high-resolution identification of subsets of these cells in the heart, enabling us to study the outcomes of metabolic distress on the cardiac macrophage infiltrate and to identify a macrophage-to-cardiomyocyte regulatory axis. To test whether a clinically relevant sodium glucose cotransporter-2 inhibitor could ameliorate the cardiac immune infiltrate profile in our model, mice were randomized to receive the sodium glucose cotransporter-2 inhibitor dapagliflozin or vehicle for 8 weeks.

 Results:  ApoE knockout mice fed a Western diet presented with reduced diastolic function, reduced exercise tolerance, and increased pulmonary congestion associated with cardiac lipid overload and reduced polyunsaturated fatty acids. The main immune cell types infiltrating the heart included 4 subpopulations of resident and monocyte-derived macrophages, determining a proinflammatory profile exclusively in ApoE knockout- Western diet mice. Lipid overload had a direct effect on inflammatory gene activation in macrophages, mediated through endoplasmic reticulum stress pathways. Investigation of the macrophage-to-cardiomyocyte regulatory axis revealed the potential effects on cardiomyocytes of multiple inflammatory cytokines secreted by macrophages, affecting pathways such as hypertrophy, fibrosis, and autophagy. Finally, we describe an anti-inflammatory effect of sodium glucose cotransporter-2 inhibitor in this model.

 Conclusions:  Using single-cell RNA sequencing , in a model of diastolic dysfunction driven by hyperlipidemia, we have determined the effects of metabolic distress on cardiac inflammatory cells, in particular on macrophages, and suggest sodium glucose cotransporter-2 inhibitors as potential therapeutic agents for the targeting of a specific phenotype of HFpEF
DOI: 10.5281/zenodo.10533107
title: Link to dataset related to article "Single-Cell RNA Sequencing Reveals Metabolic Stress-Dependent Activation of Cardiac Macrophages in a Model of Dyslipidemia-Induced Diastolic Dysfunction "

description: This record contains link to raw data related to article “Single-Cell RNA Sequencing Reveals Metabolic Stress-Dependent Activation of Cardiac Macrophages in a Model of Dyslipidemia-Induced Diastolic Dysfunction"

Abstract



 Background:  Metabolic distress is often associated with heart failure with preserved ejection fraction (HFpEF) and represents a therapeutic challenge. Metabolism-induced systemic inflammation links comorbidities with HFpEF. How metabolic changes affect myocardial inflammation in the context of HFpEF is not known.

 Methods:  We found that ApoE knockout mice fed a Western diet recapitulate many features of HFpEF. Single-cell RNA sequencing was used for expression analysis of CD45+ cardiac cells to evaluate the involvement of inflammation in diastolic dysfunction. We focused bioinformatics analysis on macrophages, obtaining high-resolution identification of subsets of these cells in the heart, enabling us to study the outcomes of metabolic distress on the cardiac macrophage infiltrate and to identify a macrophage-to-cardiomyocyte regulatory axis. To test whether a clinically relevant sodium glucose cotransporter-2 inhibitor could ameliorate the cardiac immune infiltrate profile in our model, mice were randomized to receive the sodium glucose cotransporter-2 inhibitor dapagliflozin or vehicle for 8 weeks.

 Results:  ApoE knockout mice fed a Western diet presented with reduced diastolic function, reduced exercise tolerance, and increased pulmonary congestion associated with cardiac lipid overload and reduced polyunsaturated fatty acids. The main immune cell types infiltrating the heart included 4 subpopulations of resident and monocyte-derived macrophages, determining a proinflammatory profile exclusively in ApoE knockout- Western diet mice. Lipid overload had a direct effect on inflammatory gene activation in macrophages, mediated through endoplasmic reticulum stress pathways. Investigation of the macrophage-to-cardiomyocyte regulatory axis revealed the potential effects on cardiomyocytes of multiple inflammatory cytokines secreted by macrophages, affecting pathways such as hypertrophy, fibrosis, and autophagy. Finally, we describe an anti-inflammatory effect of sodium glucose cotransporter-2 inhibitor in this model.

 Conclusions:  Using single-cell RNA sequencing , in a model of diastolic dysfunction driven by hyperlipidemia, we have determined the effects of metabolic distress on cardiac inflammatory cells, in particular on macrophages, and suggest sodium glucose cotransporter-2 inhibitors as potential therapeutic agents for the targeting of a specific phenotype of HFpEF
DOI: 10.22008/fk2/k1nnlp
title: Geologisk kort over Danmark, 1:50 000. Kortbladet Flensborg Fjord. Sedimentkort

description: Marine geology
DOI: 10.5281/zenodo.10519410
title: IEEE SciVis Contest 2023 - Dataset of Neuronal Network Simulations of the Human Brain

description: The IEEE SciVis Contest is held annually as part of the IEEE VIS Conference. It challenges participants within the visualization community to create innovative and effective state-of-the-art visualizations to analyze and understand complex scientific data. In 2023, the data described neuronal network simulations of plasticity changes in the human brain provided by a collaboration of the Crosssectional Group Parallelism and Performance, and the Crosssectional Group Visualization within the National High Performance Computing Center for Computational Engineering Science (NHR4CES).

This data contains:• 49.8 GB data• 4 simulation ensemble members• Each members consists of 50,000 neurons• Each node collects information about 12 parameters• The simulation is run for 1,000,000 simulations steps• Every 100th iteration step is sampled per node

Details can be found in the attached PDF file
DOI: 10.5281/zenodo.10519411
title: IEEE SciVis Contest 2023 - Dataset of Neuronal Network Simulations of the Human Brain

description: The IEEE SciVis Contest is held annually as part of the IEEE VIS Conference. It challenges participants within the visualization community to create innovative and effective state-of-the-art visualizations to analyze and understand complex scientific data. In 2023, the data described neuronal network simulations of plasticity changes in the human brain provided by a collaboration of the Crosssectional Group Parallelism and Performance, and the Crosssectional Group Visualization within the National High Performance Computing Center for Computational Engineering Science (NHR4CES).

This data contains:• 49.8 GB data• 4 simulation ensemble members• Each members consists of 50,000 neurons• Each node collects information about 12 parameters• The simulation is run for 1,000,000 simulations steps• Every 100th iteration step is sampled per node

Details can be found in the attached PDF file
DOI: 10.6084/m9.figshare.25027973
title: Corn Leaf aphid symbionts genetic analyses

description: Aphids are an ancient group of insects which, due especially to the human prevalence of growing a plethora of crops. We concentrate on one well-studied, now under expansion and globally important aphid pest in particular, the corn-leaf aphid <i>Rhopalosiphum maidis</i> (Fitch). In this way, we hope to show that knowledge of such interactions between insect host and its constraining abiotic and biotic factors can prove efficacious in aphid control. Whole genetic analyses of this species microbial symbionts have been analyzed, and the importance of these bacterial symbionts in aphid adaptation discussed. Here we present the whole dataset of this bacterial symbionts assessment which was made using next generation genetic tool, the Illumina systems.
DOI: 10.7488/ds/7674
title: Rapid Evolution of Colistin Resistance in a Bioreactor Model of Infection of Klebsiella pneumoniae

description: Colistin resistance remains an important antibiotic for the therapeutic management of drug-resistant Klebsiella pneumoniae. Despite the numerous reports of colistin resistance in clinical strains, it remains unclear exactly when and how different mutational events arise resulting in reduced colistin susceptibility. Using a bioreactor model of infection, we modelled the emergence of colistin resistance in a susceptible isolate of K. pneumoniae. Genotypic, phenotypic and mathematical analyses of the antibiotic challenged and un-challenged population indicates that after an initial decline, the population recovers within 24h due to a small number of “founder cells” which have single point mutations mainly in the regulatory genes encoding crrB and pmrB and whose phenotype exhibits colistin MICs up to 100-fold higher than the parental strain. Our work underlines that development of colistin resistance during treatment of susceptible K. pneumoniae infections is readily achieved having implications for the use of cationic antimicrobial peptides as a monotherapy.
DOI: 10.6084/m9.figshare.24474484
title: Gene expression of coral larvae in response to elevated temperature and acidification

description: This dataset is comprised of 16 samples collected from four treatments. These samples were collected randomly, resulting in a highly unique and valuable gene expression dataset. In combination with preciously published datasets, this new transcriptomic resource will facilitate detailed investigation of the effects of elevated temperature and acidification on coral larvae, and the potential to translate aspects of this biology to understand symbiosis.
DOI: 10.6084/m9.figshare.25028045
title: Social Disaster Scale

description: social disaster scale
DOI: 10.25500/edata.bham.00001047
title: Research data and code supporting the publication "Effect of coat-protein concentration on the self-assembly of bacteriophage MS2 capsids around RNA"
DOI: 10.5281/zenodo.10526821
title: Metabolic investigations of popular antiasthmatic drugs by an artificial lung consortium

description: Metadata files for the Masterthesis: "Metabolic investigations of popular antiasthmatic drugs by an artificial lung consortium"
DOI: 10.5281/zenodo.10526720
title: Metabolic investigations of popular antiasthmatic drugs by an artificial lung consortium

description: Metadata files for the Masterthesis: "Metabolic investigations of popular antiasthmatic drugs by an artificial lung consortium"
DOI: 10.6084/m9.figshare.25028042
title: source data file.xlsx

description: The growth and sustainable development of humanity is heavily dependent upon N<sub>2</sub> fixation. Herein we discover ambient catalyst-free disproportionation of N<sub>2</sub> by water plasma which occurs <i>via</i> the distinctive HONH-HNOH<sup>+</sup><sup>•</sup> intermediate to yield economically valuable nitroxyl (HNO) and hydroxylamine (NH<sub>2</sub>OH) products. Calculations suggest that the reaction is prompted by the coordination of electronically excited N<sub>2</sub> with water dimer radical cation, (H<sub>2</sub>O)<sub>2</sub><sup>+</sup><sup>•</sup>, in its two-center-three-electron configuration. The reaction products are collected in a 76-needle array discharge reactor with product yields of 1.14 μg cm<sup>–2 </sup>h<sup>–1</sup> for NH<sub>2</sub>OH and 0.37 μg cm<sup>–2 </sup>h<sup>–1</sup> for HNO. Potential applications of these compounds are demonstrated to make ammonia (for NH<sub>2</sub>OH), as well as to chemically react and convert cysteine, and serve as a neuroprotective agent (for HNO). The conversion of N<sub>2</sub> into HNO and NH<sub>2</sub>OH by water plasma could offer great profitability and reduction of polluting emissions, thus giving an entirely look and perspectives to the problem of green N<sub>2</sub> fixation.
DOI: 10.25573/data.10059542.v16
title: Monthly summary_Sea Surface Temperature

description: Monthly summary of sea surface temperature data collected from near shore temperature sensors at depths ranging from 1m to 20m<br>
DOI: 10.5281/zenodo.10533138
title: Perm UFSIN News Crawl Pt.2

description: WARC files produced by a webcrawl of Perm UFSIN news online resource. WARC reader is necessary to view files.
DOI: 10.5281/zenodo.10533139
title: Perm UFSIN News Crawl Pt.2

description: WARC files produced by a webcrawl of Perm UFSIN news online resource. WARC reader is necessary to view files.
DOI: 10.34740/kaggle/dsv/7434827
title: 2021 World Population (updated daily)
DOI: 10.25502/b8f0-4t77/d
title: Genetic and environmental effects on processing productivity and food product yield: drudgery of women's work

description: Participatory Processing Diagnosis for Gari/Eba in Nigeria and Cameroon to understand processors' cassava trait preferences that drive and enhance adoption and utilisation
DOI: 10.5281/zenodo.10526893
title: MUSES Near-Infrared Reflectance of Vegetation (NIRV) 16-Day 30m Geographic Grid over Beijing Since 1984

description: The MUltiscale Satellite remotE Sensing (MUSES) product suite includes products with different spatial and temporal resolutions for parameters such as Normalized Difference Vegetation Index (NDVI), Near-Infrared Reflectance of Vegetation (NIRV), Leaf Area Index (LAI), Fraction of Absorbed Photosynthetically Active Radiation (FAPAR), Fractional Vegetation Coverage (FVC), Gross Primary Production (GPP), Net Primary Production (NPP). For more information about the MUSES products, please refer to this website (https://muses.bnu.edu.cn/).

This dataset is the MUSES NIRV product at 30 m spatial resolution and 16-day temporal resolution over Beijing. The MUSES NIRV product is provided on Geographic grid and spans from 1984 to 2022 (continuously updated). It was generated from the Landsat collection 2 surface reflectance data using a temporally continuous vegetation indices-based land-surface reflectance reconstruction (VIRR) method (Xiao et al., 2015; Xiao et al., 2017). The MUSES NIRV product is spatially complete and temporally continuous.

Dataset Characteristics:



Spatial Coverage: 115.416599º E – 117.508219º E, 39.441929º N – 41.059283º N

Temporal Coverage: 1984 – 2022

Spatial Resolution: 0.000269469º (approximately 30 m)

Temporal Resolution: 16 days

Projection: Geographic

Data Format: HDF

Scale: 0.0001

Valid Range: 0 – 10000


Citation (Please cite this paper whenever these data are used):



Xiao Zhiqiang, et al. (2015). Reconstruction of Satellite-Retrieved Land-Surface Reflectance Based on Temporally-Continuous Vegetation Indices. Remote Sensing, 7, 9844-9864

Xiao Zhiqiang, et al. (2017). Reconstruction of Long-Term Temporally Continuous NDVI and Surface Reflectance From AVHRR Data. IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing, 10, 5551-5568


If you have any questions, please contact Prof. Zhiqiang Xiao (zhqxiao@bnu.edu.cn).
DOI: 10.5281/zenodo.10526894
title: MUSES Near-Infrared Reflectance of Vegetation (NIRV) 16-Day 30m Geographic Grid over Beijing Since 1984

description: The MUltiscale Satellite remotE Sensing (MUSES) product suite includes products with different spatial and temporal resolutions for parameters such as Normalized Difference Vegetation Index (NDVI), Near-Infrared Reflectance of Vegetation (NIRV), Leaf Area Index (LAI), Fraction of Absorbed Photosynthetically Active Radiation (FAPAR), Fractional Vegetation Coverage (FVC), Gross Primary Production (GPP), Net Primary Production (NPP). For more information about the MUSES products, please refer to this website (https://muses.bnu.edu.cn/).

This dataset is the MUSES NIRV product at 30 m spatial resolution and 16-day temporal resolution over Beijing. The MUSES NIRV product is provided on Geographic grid and spans from 1984 to 2022 (continuously updated). It was generated from the Landsat collection 2 surface reflectance data using a temporally continuous vegetation indices-based land-surface reflectance reconstruction (VIRR) method (Xiao et al., 2015; Xiao et al., 2017). The MUSES NIRV product is spatially complete and temporally continuous.

Dataset Characteristics:



Spatial Coverage: 115.416599º E – 117.508219º E, 39.441929º N – 41.059283º N

Temporal Coverage: 1984 – 2022

Spatial Resolution: 0.000269469º (approximately 30 m)

Temporal Resolution: 16 days

Projection: Geographic

Data Format: HDF

Scale: 0.0001

Valid Range: 0 – 10000


Citation (Please cite this paper whenever these data are used):



Xiao Zhiqiang, et al. (2015). Reconstruction of Satellite-Retrieved Land-Surface Reflectance Based on Temporally-Continuous Vegetation Indices. Remote Sensing, 7, 9844-9864

Xiao Zhiqiang, et al. (2017). Reconstruction of Long-Term Temporally Continuous NDVI and Surface Reflectance From AVHRR Data. IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing, 10, 5551-5568


If you have any questions, please contact Prof. Zhiqiang Xiao (zhqxiao@bnu.edu.cn).
DOI: 10.34740/kaggle/dsv/7434861
title: YouTube Trending Video Dataset (updated daily)
DOI: 10.6084/m9.figshare.25028291
title: Detrital zircon and heavy mineral provenance from the Palu Formation, Sulawesi, Indonesia: constraints on exhumation of the Palu Metamorphic Complex and drainage evolution

description: Supplementary File 1. Observation locations.
DOI: 10.6084/m9.figshare.25028291.v1
title: Detrital zircon and heavy mineral provenance from the Palu Formation, Sulawesi, Indonesia: constraints on exhumation of the Palu Metamorphic Complex and drainage evolution

description: Supplementary File 1. Observation locations.
DOI: 10.6084/m9.figshare.25028294
title: Detrital zircon and heavy mineral provenance from the Palu Formation, Sulawesi, Indonesia: constraints on exhumation of the Palu Metamorphic Complex and drainage evolution

description: Supplementary File 3. Data table for LA-ICP-MS U-Pb zircon analysis and zircon morphology observation of sample ES13-255 (Palu Formation).
DOI: 10.6084/m9.figshare.25028294.v1
title: Detrital zircon and heavy mineral provenance from the Palu Formation, Sulawesi, Indonesia: constraints on exhumation of the Palu Metamorphic Complex and drainage evolution

description: Supplementary File 3. Data table for LA-ICP-MS U-Pb zircon analysis and zircon morphology observation of sample ES13-255 (Palu Formation).
DOI: 10.6084/m9.figshare.25028297
title: Detrital zircon and heavy mineral provenance from the Palu Formation, Sulawesi, Indonesia: constraints on exhumation of the Palu Metamorphic Complex and drainage evolution

description: Supplementary File 2. Heavy mineral point counting.
DOI: 10.6084/m9.figshare.25028297.v1
title: Detrital zircon and heavy mineral provenance from the Palu Formation, Sulawesi, Indonesia: constraints on exhumation of the Palu Metamorphic Complex and drainage evolution

description: Supplementary File 2. Heavy mineral point counting.
DOI: 10.6084/m9.figshare.25028171
title: FBP.SBP KO in CMM with 13C-glycerol

description: <i>Trypanosoma brucei</i> is a causative agent of the Human and Animal African Trypanosomiases. The mammalian stage parasites infect various tissues and organs including the bloodstream, central nervous system, skin, adipose tissue and lungs. They rely on ATP produced in glycolysis, consuming large amounts of glucose, which is readily available in the mammalian host. In addition to glucose, glycerol can also be used as a source of carbon and ATP and as a substrate for gluconeogenesis. However, the physiological relevance of glycerol-fed gluconeogenesis for the mammalian-infective life cycle forms remains elusive. To demonstrate its (in)dispensability, first we must identify the enzyme(s) of the pathway. Loss of the canonical gluconeogenic enzyme, fructose-1,6-bisphosphatase, does not abolish the process hence at least one other enzyme must participate in gluconeogenesis in trypanosomes. Using a combination of CRISPR/Cas9 gene editing and RNA interference, we generated mutants for four enzymes potentially capable of contributing to gluconeogenesis: fructose-1,6-bisphoshatase, sedoheptulose-1,7-bisphosphatase, phosphofructokinase and transaldolase, alone or in various combinations. Metabolomic analyses revealed that flux through gluconeogenesis was maintained irrespective of which of these genes were lost. Our data render unlikely a previously hypothesised role of a reverse phosphofructokinase reaction in gluconeogenesis and preclude the participation of a novel biochemical pathway involving transaldolase in the process. The sustained metabolic flux in gluconeogenesis in our mutants, including a triple-null strain, indicates the presence of a unique enzyme participating in gluconeogenesis. Additionally, the data provide new insights into gluconeogenesis and the pentose phosphate pathway, and improve the current understanding of carbon metabolism of the mammalian-infective stages of <i>T. brucei</i>.