cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.5035751.v1
title: Palaeoproterozoic granitic magmatism in the northern segment of the Jiao-Liao-Ji Belt: implications for orogenesis along the Eastern Block of the North China Craton

description: As the northern segment of the Jiao-Liao-Ji Belt (JLJB), the Palaeoproterozoic Liaoji Belt is a key region for deciphering the formation and evolution of the North China Craton (NCC). In this study, we present the geochronology, geochemical, and isotopic studies on the monzogranitic gneiss, which is one of the major lithotectonic elements of the Liaoji Belt. LA-ICP-MS zircon U–Pb dating reveals that the studied monzogranitic gneisses were formed in the period of 2213–2178 Ma. They are in tectonic contact with the Palaeoproterozoic volcano-sedimentary rocks in the field. The monzogranitic gneisses belong to the high-K calc-alkaline series, and are metaluminous to peraluminous. They have 10,000 Ga/Al ratios of 2.63–3.14 with an average of 2.90, and are thus classified as aluminous A-type granites. Their <i>ε</i><sub>Nd</sub>(<i>t</i>) values vary from −3.4 to +2.5, indicating heterogeneous source region. The monzogranitic gneisses are characterized by enrichment in LREE and LILE (e.g. Rb, Ba, Th, and K) and depletion in HREE and HFSE (such as Nb, Ta, and Ti), and are typical to magmatism in active continental margins formed in a subduction-related tectonic setting. Taking into account their A-type affinity and regional geological data, we suggest that the monzogranitic gneisses were most probably generated in a local extensional back-arc environment during subduction.
DOI: 10.6084/m9.figshare.5039186
title: Reconstructing Palaeozoic and Mesozoic tectonic evolution of Novaya Zemlya: combing geochronology and thermochronology

description: Detrital zircon U–Pb LA-ICP-MS data of samples from Novaya Zemlya.
DOI: 10.6084/m9.figshare.5039186.v1
title: Reconstructing Palaeozoic and Mesozoic tectonic evolution of Novaya Zemlya: combing geochronology and thermochronology

description: Detrital zircon U–Pb LA-ICP-MS data of samples from Novaya Zemlya.
DOI: 10.6084/m9.figshare.5048650
title: The Effect of the Sloping Land Conversion Programme on Farm Household Productivity in Rural China

description: The objective of this paper is to examine the treatment effect on farm household productivity induced by the Sloping Land Conversion Program. Using large balanced household level data from five provinces during 1996–2010, this study shows that the SLCP significantly improved the productivity of participants during the first round of funding of the programme until 2008, while the effects decreased gradually in the second round with most years not showing significant differences. Moreover, it is found that there are heterogeneous effects on farm household productivity between the south and north, as well as between poor and rich regions.
DOI: 10.6084/m9.figshare.5048650.v1
title: The Effect of the Sloping Land Conversion Programme on Farm Household Productivity in Rural China

description: The objective of this paper is to examine the treatment effect on farm household productivity induced by the Sloping Land Conversion Program. Using large balanced household level data from five provinces during 1996–2010, this study shows that the SLCP significantly improved the productivity of participants during the first round of funding of the programme until 2008, while the effects decreased gradually in the second round with most years not showing significant differences. Moreover, it is found that there are heterogeneous effects on farm household productivity between the south and north, as well as between poor and rich regions.
DOI: 10.5281/zenodo.10866582
title: Supplementary Data for Study on Strain Localization of Strike-Slip Fault Systems

description: Point displacement measurements of fault slip from geodetic imaging and field surveying used to estimate off-fault deformation.
DOI: 10.5281/zenodo.10866583
title: Supplementary Data for Study on Strain Localization of Strike-Slip Fault Systems

description: Point displacement measurements of fault slip from geodetic imaging and field surveying used to estimate off-fault deformation.
DOI: 10.6084/m9.figshare.5057089
title: A model-free feature screening approach based on kernel density estimation

description: In this article, a new model-free feature screening method named after probability density (mass) function distance (PDFD) correlation is presented for ultrahigh-dimensional data analysis. We improve the fused-Kolmogorov filter (F-KOL) screening procedure through probability density distribution. The proposed method is also fully nonparametric and can be applied to more general types of predictors and responses, including discrete and continuous random variables. Kernel density estimate method and numerical integration are applied to obtain the estimator we proposed. The results of simulation studies indicate that the fused-PDFD performs better than other existing screening methods, such as F-KOL filter, sure-independent screening (SIS), sure independent ranking and screening (SIRS), distance correlation sure-independent screening (DCSIS) and robust ranking correlation screening (RRCS). Finally, we demonstrate the validity of fused-PDFD by a real data example.
DOI: 10.6084/m9.figshare.5057089.v1
title: A model-free feature screening approach based on kernel density estimation

description: In this article, a new model-free feature screening method named after probability density (mass) function distance (PDFD) correlation is presented for ultrahigh-dimensional data analysis. We improve the fused-Kolmogorov filter (F-KOL) screening procedure through probability density distribution. The proposed method is also fully nonparametric and can be applied to more general types of predictors and responses, including discrete and continuous random variables. Kernel density estimate method and numerical integration are applied to obtain the estimator we proposed. The results of simulation studies indicate that the fused-PDFD performs better than other existing screening methods, such as F-KOL filter, sure-independent screening (SIS), sure independent ranking and screening (SIRS), distance correlation sure-independent screening (DCSIS) and robust ranking correlation screening (RRCS). Finally, we demonstrate the validity of fused-PDFD by a real data example.
DOI: 10.6084/m9.figshare.5067745
title: Production of 1,3-propanediol from glycerol using a new isolate <i>Klebsiella</i> sp. AA405 carrying low levels of virulence factors

description: <i>Klebsiella pneumoniae</i> is a promising industrial species for the production of chemicals, yet its opportunistic pathogenicity restrains real-world applications. In this work, we identified a novel isolate designated <i>Klebsiella</i> sp. AA405 which carried low levels of virulence factors. No capsule, fimbriae and flagella were observed around colonies. Genome alignment between <i>Klebsiella</i> sp. AA405 and other 186 <i>Klebsiella</i> species revealed 3421 homologous genes. Notably, the endotoxin of <i>Klebsiella</i> sp. AA405 was only half of <i>E</i>. <i>coli</i> BL21. This strain matched well with common cloning and expression vectors and was sensitive to antibiotics. More importantly, this strain metabolized diverse carbon sources. Under micro-aerobic conditions, it produced 51.66 g/L 1,3-propanediol, 3.82 g/L 3-hydroxypropionic acid and 6.86 g/L 2,3-butanediol in a 5 L bioreactor using glycerol as the sole carbon source. Overall these results indicate that <i>Klebsiella</i> sp. AA405 is a promising strain for the production of bulk chemicals.
DOI: 10.6084/m9.figshare.5067745.v1
title: Production of 1,3-propanediol from glycerol using a new isolate <i>Klebsiella</i> sp. AA405 carrying low levels of virulence factors

description: <i>Klebsiella pneumoniae</i> is a promising industrial species for the production of chemicals, yet its opportunistic pathogenicity restrains real-world applications. In this work, we identified a novel isolate designated <i>Klebsiella</i> sp. AA405 which carried low levels of virulence factors. No capsule, fimbriae and flagella were observed around colonies. Genome alignment between <i>Klebsiella</i> sp. AA405 and other 186 <i>Klebsiella</i> species revealed 3421 homologous genes. Notably, the endotoxin of <i>Klebsiella</i> sp. AA405 was only half of <i>E</i>. <i>coli</i> BL21. This strain matched well with common cloning and expression vectors and was sensitive to antibiotics. More importantly, this strain metabolized diverse carbon sources. Under micro-aerobic conditions, it produced 51.66 g/L 1,3-propanediol, 3.82 g/L 3-hydroxypropionic acid and 6.86 g/L 2,3-butanediol in a 5 L bioreactor using glycerol as the sole carbon source. Overall these results indicate that <i>Klebsiella</i> sp. AA405 is a promising strain for the production of bulk chemicals.
DOI: 10.6084/m9.figshare.5072665
title: Data and code to reproduce Dallas et al. "Estimating parasite host range"

description: This repository contains code and data (only for the Sevilleta LTER) to reproduce the analyses from:<br>&gt; Dallas,T, S Huang, C Nunn, A Park, and JM Drake. 2017. "Estimating parasite host range". Proceedings of the Royal Society B. <br>The Global Mammal Parasite Database is available at https://doi.org/10.1002/ecy.1799
DOI: 10.6084/m9.figshare.5074084
title: Raw reads for 12 MinION sequencing samples and 21 assembled plasmids

description: These twelve samples were MDR plasmids sequenced in a single MinION nanopore sequencing run with SQK-RBK001 kit.
DOI: 10.6084/m9.figshare.5074084.v1
title: Raw reads for 12 MinION sequencing samples

description: These twelve samples were MDR plasmids sequenced in a single MinION nanopore sequencing run with SQK-RBK001 kit.
DOI: 10.6084/m9.figshare.5074084.v2
title: Raw reads for 12 MinION sequencing samples and 21 assembled plasmids

description: These twelve samples were MDR plasmids sequenced in a single MinION nanopore sequencing run with SQK-RBK001 kit.
DOI: 10.6084/m9.figshare.5084266
title: Preliminary investigation of a water-based method for fast integrating mobility spectrometry

description: A water-based condensational growth channel was developed for imaging mobility-separated particles within a parallel plate separation channel of the Fast Integrated Mobility Spectrometer (FIMS). Reported are initial tests of that system, in which the alcohol condenser of the FIMS was replaced by a water-based condensational growth channel. Tests with monodispersed sodium chloride aerosol verify that the water-condensational growth maintained the laminar flow, while providing sufficient growth for particle imaging. Particle positions mapped onto particle mobility, in accordance with theoretical expectations. Particles ranging in size from 12 nm to 100 nm were counted with the same efficiency as with a butanol-based ultrafine particle counter, once inlet and line losses were taken into account. Copyright © 2017 American Association for Aerosol Research
DOI: 10.6084/m9.figshare.5084266.v2
title: Preliminary investigation of a water-based method for fast integrating mobility spectrometry

description: A water-based condensational growth channel was developed for imaging mobility-separated particles within a parallel plate separation channel of the Fast Integrated Mobility Spectrometer (FIMS). Reported are initial tests of that system, in which the alcohol condenser of the FIMS was replaced by a water-based condensational growth channel. Tests with monodispersed sodium chloride aerosol verify that the water-condensational growth maintained the laminar flow, while providing sufficient growth for particle imaging. Particle positions mapped onto particle mobility, in accordance with theoretical expectations. Particles ranging in size from 12 nm to 100 nm were counted with the same efficiency as with a butanol-based ultrafine particle counter, once inlet and line losses were taken into account. Copyright © 2017 American Association for Aerosol Research
DOI: 10.6084/m9.figshare.5084266.v1
title: Preliminary Investigation of a Water-based Method for Fast Integrating Mobility Spectrometry

description: A water-based condensational growth channel was developed for imaging mobility-separated particles within a parallel plate separation channel of the Fast Integrated Mobility Spectrometer (FIMS). Reported are initial tests of that system, in which the alcohol condenser of the FIMS was replaced by a water-based condensational growth channel. Tests with monodispersed sodium chloride aerosol verify that the water-condensational growth maintained the laminar flow, while providing sufficient growth for particle imaging. Particle positions mapped onto particle mobility, in accordance with theoretical expectations. Particles ranging in size from 12 nm to 100 nm were counted with the same efficiency as with a butanol-based ultrafine particle counter, once inlet and line losses were taken into account.
DOI: 10.6084/m9.figshare.5085085
title: The cryo-thermal therapy-induced IL-6-rich acute pro-inflammatory response promoted DCs phenotypic maturation as the prerequisite to CD4<sup>+</sup> T cell differentiation

description: In our previous studies, a novel tumour therapeutic modality of the cryo-thermal therapy has been developed leading to long-term survival in 4T1 murine mammary carcinoma model. The cryo-thermal therapy induced the strong acute inflammatory response and IL-6 was identified in an acute profile. In this study, we found that the cryo-thermal therapy triggered robust acute inflammatory response with high expression of IL-6 locally and systemically. The phenotypic maturation of dendritic cells (DCs) was induced by acute IL-6 following the treatment. The mature DCs promoted CD4<sup>+</sup> T cell differentiation. Moreover, the production of interferon γ (IFN γ) in the serum and CD4<sup>+</sup> T cells were both abrogated by IL-6 neutralisation following the treatment. Our findings revealed that the cryo-thermal therapy-induced acute IL-6 played an important role in initiating the cascading innate and adaptive anti-tumour immune responses, resulting in CD4<sup>+</sup> T cell differentiation. It would be interesting to investigate acute IL-6 as an early indicator in predicating tumour therapeutic effect.
DOI: 10.6084/m9.figshare.5085085.v1
title: The cryo-thermal therapy-induced IL-6-rich acute pro-inflammatory response promoted DCs phenotypic maturation as the prerequisite to CD4<sup>+</sup> T cell differentiation

description: In our previous studies, a novel tumour therapeutic modality of the cryo-thermal therapy has been developed leading to long-term survival in 4T1 murine mammary carcinoma model. The cryo-thermal therapy induced the strong acute inflammatory response and IL-6 was identified in an acute profile. In this study, we found that the cryo-thermal therapy triggered robust acute inflammatory response with high expression of IL-6 locally and systemically. The phenotypic maturation of dendritic cells (DCs) was induced by acute IL-6 following the treatment. The mature DCs promoted CD4<sup>+</sup> T cell differentiation. Moreover, the production of interferon γ (IFN γ) in the serum and CD4<sup>+</sup> T cells were both abrogated by IL-6 neutralisation following the treatment. Our findings revealed that the cryo-thermal therapy-induced acute IL-6 played an important role in initiating the cascading innate and adaptive anti-tumour immune responses, resulting in CD4<sup>+</sup> T cell differentiation. It would be interesting to investigate acute IL-6 as an early indicator in predicating tumour therapeutic effect.
DOI: 10.6084/m9.figshare.5086951
title: Merotelic kinetochore attachment in oocyte meiosis II causes sister chromatids segregation errors in aged mice

description: Mammalian oocyte chromosomes undergo 2 meiotic divisions to generate haploid gametes. The frequency of chromosome segregation errors during meiosis I increase with age. However, little attention has been paid to the question of how aging affects sister chromatid segregation during oocyte meiosis II. More importantly, how aneuploid metaphase II (MII) oocytes from aged mice evade the spindle assembly checkpoint (SAC) mechanism to complete later meiosis II to form aneuploid embryos remains unknown. Here, we report that MII oocytes from naturally aged mice exhibited substantial errors in chromosome arrangement and configuration compared with young MII oocytes. Interestingly, these errors in aged oocytes had no impact on anaphase II onset and completion as well as 2-cell formation after parthenogenetic activation. Further study found that merotelic kinetochore attachment occurred more frequently and could stabilize the kinetochore-microtubule interaction to ensure SAC inactivation and anaphase II onset in aged MII oocytes. This orientation could persist largely during anaphase II in aged oocytes, leading to severe chromosome lagging and trailing as well as delay of anaphase II completion. Therefore, merotelic kinetochore attachment in oocyte meiosis II exacerbates age-related genetic instability and is a key source of age-dependent embryo aneuploidy and dysplasia.
DOI: 10.6084/m9.figshare.5086951.v1
title: Merotelic kinetochore attachment in oocyte meiosis II causes sister chromatids segregation errors in aged mice

description: Mammalian oocyte chromosomes undergo 2 meiotic divisions to generate haploid gametes. The frequency of chromosome segregation errors during meiosis I increase with age. However, little attention has been paid to the question of how aging affects sister chromatid segregation during oocyte meiosis II. More importantly, how aneuploid metaphase II (MII) oocytes from aged mice evade the spindle assembly checkpoint (SAC) mechanism to complete later meiosis II to form aneuploid embryos remains unknown. Here, we report that MII oocytes from naturally aged mice exhibited substantial errors in chromosome arrangement and configuration compared with young MII oocytes. Interestingly, these errors in aged oocytes had no impact on anaphase II onset and completion as well as 2-cell formation after parthenogenetic activation. Further study found that merotelic kinetochore attachment occurred more frequently and could stabilize the kinetochore-microtubule interaction to ensure SAC inactivation and anaphase II onset in aged MII oocytes. This orientation could persist largely during anaphase II in aged oocytes, leading to severe chromosome lagging and trailing as well as delay of anaphase II completion. Therefore, merotelic kinetochore attachment in oocyte meiosis II exacerbates age-related genetic instability and is a key source of age-dependent embryo aneuploidy and dysplasia.
DOI: 10.6084/m9.figshare.5087047
title: Formation process of mid-Neoproterozoic mafic rocks from the western Jiangnan Orogen, South China: insights from SHRIMP U–Pb dating and geochemical analysis

description: The mid-Neoproterozoic tectonic setting of the Jiangnan Orogen (JO) is uncertain due to the ongoing debate regarding the history of interactions between the Yangtze and Cathaysia Blocks. Extensive magmatic rocks with ages &gt;830 Ma are observed in the eastern JO and are reported to indicate their formation conditions; however, such magmatic rocks are rare in the western JO. This paper presents data from samples collected from two ultramafic intrusions in northern Guangxi province that yield SHRIMP U–Pb ages of 848 ± 7 and 836 ± 5 Ma. These two intrusions have similar geochemical compositions; are enriched in LILE (Rb, Ba, Th, and Pb) relative to HFSE (Hf, Zr, Nb, Ta, and Y), reflecting an arc-like signature; and are derived from the same source. The intrusions have positive εNd(t) and εHf(t) values, implying a depleted mantle source. Comparing the Neoproterozoic mafic–ultramafic rocks of the JO, differences exist between the rocks that formed at 860–830, 830–800, and 800–740 Ma in terms of their mantle sources and formation conditions. Considering the geochemical composition and ages of formation of the strata and the deep structure of the western JO, we speculate that the western JO was a back-arc foreland basin, which experienced shallow subduction-related and arc-like magmatism during the period between 860 and 830 million years. In contrast to the western JO, the eastern JO may have been a back-arc basin with oceanic crustal basement during that time. The JO formed between 830 and 800 million years in association with subduction-related collisional magmatism due to the amalgamation of the Yangtze and Cathaysia Blocks. Subsequently, magmatism occurred in the JO that resulted from the post-orogenic extension.
DOI: 10.6084/m9.figshare.5087047.v1
title: Formation process of mid-Neoproterozoic mafic rocks from the western Jiangnan Orogen, South China: insights from SHRIMP U–Pb dating and geochemical analysis

description: The mid-Neoproterozoic tectonic setting of the Jiangnan Orogen (JO) is uncertain due to the ongoing debate regarding the history of interactions between the Yangtze and Cathaysia Blocks. Extensive magmatic rocks with ages &gt;830 Ma are observed in the eastern JO and are reported to indicate their formation conditions; however, such magmatic rocks are rare in the western JO. This paper presents data from samples collected from two ultramafic intrusions in northern Guangxi province that yield SHRIMP U–Pb ages of 848 ± 7 and 836 ± 5 Ma. These two intrusions have similar geochemical compositions; are enriched in LILE (Rb, Ba, Th, and Pb) relative to HFSE (Hf, Zr, Nb, Ta, and Y), reflecting an arc-like signature; and are derived from the same source. The intrusions have positive εNd(t) and εHf(t) values, implying a depleted mantle source. Comparing the Neoproterozoic mafic–ultramafic rocks of the JO, differences exist between the rocks that formed at 860–830, 830–800, and 800–740 Ma in terms of their mantle sources and formation conditions. Considering the geochemical composition and ages of formation of the strata and the deep structure of the western JO, we speculate that the western JO was a back-arc foreland basin, which experienced shallow subduction-related and arc-like magmatism during the period between 860 and 830 million years. In contrast to the western JO, the eastern JO may have been a back-arc basin with oceanic crustal basement during that time. The JO formed between 830 and 800 million years in association with subduction-related collisional magmatism due to the amalgamation of the Yangtze and Cathaysia Blocks. Subsequently, magmatism occurred in the JO that resulted from the post-orogenic extension.
DOI: 10.6084/m9.figshare.5092171
title: Hepatotoxicity evaluation of traditional Chinese medicines using a computational molecular model

description: <b>Background:</b> Liver injury caused by traditional Chinese medicines (TCMs) is reported from many countries around the world. TCM hepatotoxicity has attracted worldwide concerns. <b>Objective:</b> This study aims to develop a more applicable and optimal tool to evaluate TCM hepatotoxicity. <b>Methods:</b> A quantitative structure-activity relationship (QSAR) analysis was performed based on published data and U.S. Food and Drug Administration’s Liver Toxicity Knowledge Base (LTKB). <b>Results:</b> Eleven herbal ingredients with proven liver toxicity in the literature were added into the dataset besides chemicals from LTKB. The finally generated QSAR model yielded a sensitivity of 83.8%, a specificity of 70.1%, and an accuracy of 80.2%. Among the externally tested 20 ingredients from TCMs, 14 hepatotoxic ingredients were all accurately identified by the QSAR model derived from the dataset containing natural hepatotoxins. <b>Conclusions:</b> Adding natural hepatotoxins into the dataset makes the QSAR model more applicable for TCM hepatotoxicity assessment, which provides a right direction in the methodology study for TCM safety evaluation. The generated QSAR model has the practical value to prioritize the hepatotoxicity risk of TCM compounds. Furthermore, an open-access international specialized database on TCM hepatotoxicity should be quickly established.