cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.5281/zenodo.3713343
title: Dataset related to article "Chemotherapy accelerates immune-senescence and functional impairments of Vδ2pos T cells in elderly patients affected by liver metastatic colorectal cancer."

description: Human (gamma delta) γδ T cells are unconventional innate-like lymphocytes displaying a broad array of anti-tumor activities with promising perspectives in cancer immunotherapy. In this context, Vδ2<sup>pos</sup> T cells represent the preferential target of several immunotherapy protocols against solid tumors. However, the impact of both aging and chemotherapy (CHT) on Vδ2<sup>pos</sup> T cells is still unknown. The present study evaluates with multi-parametric flow cytometry the frequencies, terminal differentiation, senescence and effector-functions of peripheral blood and tumor infiltrating Vδ2<sup>pos</sup> T cells purified from liver metastases (CLM) of patients affected by colorectal cancer (CRC) compared to those of sex- and age-matched healthy donors. The peripheral blood of CLM patients underwent CHT is characterized by decreased amounts of Vδ2<sup>pos</sup> T cells showing a relative increase of terminally-differentiated CD27<sup>neg</sup>/CD45RA<sup>pos</sup> (T<sub>EMRA</sub>) cells. The enrichment of this latter subset is associated with an increased expression of the senescent marker CD57. The acquisition of CD57 on T<sub>EMRA</sub> Vδ2<sup>pos</sup> T cells is also coupled with impairments in cytotoxicity and production of TNF-α and IFN-γ. These features resemble the acquisition of an immune-senescent profile by Vδ2<sup>pos</sup> T cells from CLM patients that received CHT, a phenomenon that is also associated with the loss of the co-stimulatory marker CD28 and with the induced expression of CD16. The group of CLM patients underwent CHT and older than 60 years old showed higher frequencies of CD57<sup>pos</sup> and T<sub>EMRA</sub> Vδ2<sup>pos</sup> T cells. Similar results were found for tumor infiltrating Vδ2<sup>pos</sup> T cell subset purified from CLM specimens of patients treated with CHT. The toxicity of CHT regimens also affects the homeostasis of Vδ2<sup>pos</sup> T cells by inducing higher frequencies of circulating CD57<sup>pos</sup> T<sub>EMRA</sub> subset in CLM underwent CHT and younger than 60 years old. Taken together, our data demonstrate that the enrichment of senescent Vδ2<sup>pos</sup> T cells in CLM patients is not only induced by patients' aging but also by the toxicity of CHT that further accelerates the accumulation of CD57<sup>pos</sup> T<sub>EMRA</sub> cells highly dysfunctional in their anti-tumor activities. These results are important to both predict the clinical outcome of CLM and to optimize those protocols of cell cancer immunotherapy employing unconventional Vδ2<sup>pos</sup> T cells.
DOI: 10.21223/p3/lxo6o2/73xil8
title: PTMinerals072018_CCASAP_exp1.tab

description: :unav
DOI: 10.21223/p3/lxo6o2/oyvuea
title: PTVitaminC072018_CCASAP_exp1.tab

description: :unav
DOI: 10.21223/p3/lxo6o2/yjejpc
title: Data_dictionary.xls

description: :unav
DOI: 10.14272/bhcggvivfxwati-uhfffaoysa-n.1
title: 1-[4-(1-hydroxyethyl)phenyl]ethanol
title: InChI=1S/C10H14O2/c1-7(11)9-3-5-10(6-4-9)8(2)12/h3-8,11-12H,1-2H3

description: This dataset contains experimental data from a sample (1-[4-(1-hydroxyethyl)phenyl]ethanol, InChI=1S/C10H14O2/c1-7(11)9-3-5-10(6-4-9)8(2)12/h3-8,11-12H,1-2H3). The datasets from the following experiments are available: 1H nuclear magnetic resonance spectroscopy (1H NMR) 13C nuclear magnetic resonance spectroscopy (13C NMR) mass spectrometry (MS)
DOI: 10.14272/bhcggvivfxwati-uhfffaoysa-n/chmo0000470
title: mass spectrometry (MS) (1-[4-(1-hydroxyethyl)phenyl]ethanol)
title: InChI=1S/C10H14O2/c1-7(11)9-3-5-10(6-4-9)8(2)12/h3-8,11-12H,1-2H3

description: dataset for mass spectrometry (MS) EI (m/z, 70 eV, 50 °C): 166 (30) [M+], 151 (100) [M+ – CH3], 131 (18), 105 (63), 79 (28), 77 (21), 69 (32). HRMS–EI (m/z): [M]+ calcd for C10H14O2, 166.0988; found 166.0990.
DOI: 10.14272/bhcggvivfxwati-uhfffaoysa-n/chmo0000593
title: 1H nuclear magnetic resonance spectroscopy (1H NMR) (1-[4-(1-hydroxyethyl)phenyl]ethanol)
title: InChI=1S/C10H14O2/c1-7(11)9-3-5-10(6-4-9)8(2)12/h3-8,11-12H,1-2H3

description: dataset for 1H nuclear magnetic resonance spectroscopy (1H NMR) 1H NMR (400 MHz, Chloroform-d (s) [7.27 ppm], ppm) δ = 7.33 (s, 4H), 4.87 (q, J = 6.6 Hz, 2H), 2.36 (bs, 2H), 1.48 (d, J = 6.6 Hz, 6H).
DOI: 10.14272/bhcggvivfxwati-uhfffaoysa-n/chmo0000595
title: 13C nuclear magnetic resonance spectroscopy (13C NMR) (1-[4-(1-hydroxyethyl)phenyl]ethanol)
title: InChI=1S/C10H14O2/c1-7(11)9-3-5-10(6-4-9)8(2)12/h3-8,11-12H,1-2H3

description: dataset for 13C nuclear magnetic resonance spectroscopy (13C NMR) 13C NMR (100 MHz, CDCl3 [77.0 ppm], ppm) δ = 144.9 (2C), 125.5 (4C), 70.1, 70.1, 25.1 (2C).
DOI: 10.5281/zenodo.3714268
title: The GICs measurement at the Huangmeishan 220 kV substation during three storms

description: This data set includes the GICs measurements at the Huangmeishan 220 kV substation during three stroms. The storms took place during 17-18 March 2015, 14-15 December 2015 and 6-8 March 2016, respectively. The time resolution of the data is 1 minute.
DOI: 10.5281/zenodo.3714269
title: The GICs measurement at the Huangmeishan 220 kV substation during three storms

description: This data set includes the GICs measurements at the Huangmeishan 220 kV substation during three stroms. The storms took place during 17-18 March 2015, 14-15 December 2015 and 6-8 March 2016, respectively. The time resolution of the data is 1 minute.
DOI: 10.14272/xschrsmbecnvns-uhfffaoysa-n/chmo0000593
title: 1H nuclear magnetic resonance spectroscopy (1H NMR) (quinoxaline)
title: InChI=1S/C8H6N2/c1-2-4-8-7(3-1)9-5-6-10-8/h1-6H

description: dataset for 1H nuclear magnetic resonance spectroscopy (1H NMR) 1H NMR (400 MHz, CDCl3, ppm) δ = 7.74–7.84 (m, 2H), 8.08–8.17 (m, 2H), 8.86 (s, 2H).
DOI: 10.14272/xschrsmbecnvns-uhfffaoysa-n/chmo0000595
title: 13C nuclear magnetic resonance spectroscopy (13C NMR) (quinoxaline)
title: InChI=1S/C8H6N2/c1-2-4-8-7(3-1)9-5-6-10-8/h1-6H

description: dataset for 13C nuclear magnetic resonance spectroscopy (13C NMR) 13C NMR (100 MHz, CDCl3, ppm) δ = 129.7 (2C), 130.2 (2C), 143.2 (2C), 145.1 (2C).
DOI: 10.15468/xffelu
title: Revision of the genus Systellapha Enderlein (Micropezidae, Taeniapterinae)

description: This dataset contains the digitized treatments in Plazi based on the original journal article Marshall, Stephen A. (2020): Revision of the genus Systellapha Enderlein (Micropezidae, Taeniapterinae). Zootaxa 4751 (2): 369-376, DOI: https://doi.org/10.11646/zootaxa.4751.2.11
DOI: 10.14272/xschrsmbecnvns-uhfffaoysa-n.1
title: quinoxaline
title: InChI=1S/C8H6N2/c1-2-4-8-7(3-1)9-5-6-10-8/h1-6H

description: This dataset contains experimental data from a sample (quinoxaline, InChI=1S/C8H6N2/c1-2-4-8-7(3-1)9-5-6-10-8/h1-6H). The datasets from the following experiments are available: 1H nuclear magnetic resonance spectroscopy (1H NMR) 13C nuclear magnetic resonance spectroscopy (13C NMR) infrared absorption spectroscopy (IR) mass spectrometry (MS)
DOI: 10.14272/xschrsmbecnvns-uhfffaoysa-n/chmo0000470.1
title: mass spectrometry (MS) (quinoxaline)
title: InChI=1S/C8H6N2/c1-2-4-8-7(3-1)9-5-6-10-8/h1-6H

description: dataset for mass spectrometry (MS) EI (m/z, 70 eV, 20 °C): 131 (15) [M+H]+, 130 (100) [M], 103 (62), 76 (56), 75 (14), 69 (10), 52 (10), 51 (14). HRMS–EI (m/z): [M]+ calcd for C8H6N2, 130.0531; found 130.0530.
DOI: 10.14272/xschrsmbecnvns-uhfffaoysa-n/chmo0000630
title: infrared absorption spectroscopy (IR) (quinoxaline)
title: InChI=1S/C8H6N2/c1-2-4-8-7(3-1)9-5-6-10-8/h1-6H

description: dataset for infrared absorption spectroscopy (IR) IR (ATR, ṽ) = 3060, 3048, 3030, 3013, 2979, 1979, 1946, 1858, 1836, 1751, 1720, 1635, 1613, 1571, 1494, 1462, 1414, 1384, 1370, 1354, 1285, 1259, 1200, 1128, 1102, 1024, 949, 878, 866, 833, 795, 752, 635, 602, 534, 486, 470, 392 cm–1.
DOI: 10.6073/pasta/773e9e5fbc4ff681c3a1e2dc00eefabe
title: Water Quality Sampling - integrated measurements for the Virginia Coast, 1992-2019

description: This dataset contains information about the aquatic environment along two transects that run from inlet to the mainland shore on the southern part of the Delmarva Peninsula since 1992. It has a large number of columns (111) that integrate information on water column and benthic measurements. Frequency of sampling varies from monthly to quarterly, and not all variables are necessarily measured on the same dates. However, all the data from a given date and location appears on a single line of the dataset.
DOI: 10.6084/m9.figshare.11997690.v1
title: Potential of parents and hybrids experimental of the yellow melon

description: ABSTRACT: Melon or muskmelon (Cucumis melo L.) is of considerable economic importance in Brazil. Nearly all the cultivars currently grown are hybrids. Heterosis has been used to advantage in the melon plant, and the use of uniform hybrids is one of the reasons for successful cultivation. The aim of the present study was to evaluate the agronomic potential of yellow melon lines and hybrids. An experiment was conducted in randomized blocks with three replications to evaluate 24 hybrids generated by crosses among three elite lines used as female parents (AF-01, AF-02, and AF-03) and eight lines used as male parents (LAM-01, LAM-02, LAM-03, LAM-04, LAM-05, LAM-06, LAM-07, and LAM-08). Yield and fruit quality traits were evaluated. Partial diallel analysis was carried out to estimate general combining ability and specific combining ability. Additive and non-additive effects were observed for the yield, mean fruit weight, and pulp thickness traits. The lines AF-02, LAM-02, and LAM-03 are the most promising as parents as they more frequently have favorable alleles. The most prominent hybrids in diallel analysis were AF-02 x LAM-02, AF-02 x LAM-03, AF-02 x LAM-04, and AF-03 x LAM-06.
DOI: 10.25919/5e71325547aa5
title: Parkes observations for project P958 semester 2019OCTS_73

description: Fast radio bursts (FRBs) continue to raise more questions than they answer. Until last year, only one burst – the only one known to repeat - had been localized to a bright radio nebula (either a young supernova remnant or pulsar wind nebulae) in a distant dwarf galaxy. Over the last two year searches with the Australian Square Kilometre Array Pathfinder (ASKAP) have detected 31 bursts, five of which have been localised to host galaxies at redshifts ranging from 0.1 to 0.5. These bursts and their hosts are very unlike the repeater, suggesting there may be a dichotomy in the population. However one of the arcminute-localised ASKAP FRBs has recently been found to repeat. Here we propose to search and study repetitions in this FRB population. Our comprehensive sample and a dense monitoring campaign of well localised bursts, at a fluence limit more than 60 times lower than that of their detections to characterise the fraction of bursts that repeat. For bursts that repeat the unique wide bandwidth observations will be used to test leading models of burst emission.
DOI: 10.14272/xhshkwpchyitop-uhfffaoysa-n.1
title: C11H13NO2
title: InChI=1S/C11H13NO2/c1-8(13)12-11(6-7-11)9-4-2-3-5-10(9)14/h2-5,14H,6-7H2,1H3,(H,12,13)

description: This dataset contains experimental data from a sample (InChI=1S/C11H13NO2/c1-8(13)12-11(6-7-11)9-4-2-3-5-10(9)14/h2-5,14H,6-7H2,1H3,(H,12,13)). The datasets from the following experiments are available: 1H nuclear magnetic resonance spectroscopy (1H NMR) 13C nuclear magnetic resonance spectroscopy (13C NMR) distortionless enhancement with polarization transfer (DEPT) distortionless enhancement with polarization transfer (DEPT) mass spectrometry (MS) infrared absorption spectroscopy (IR)
DOI: 10.14272/xhshkwpchyitop-uhfffaoysa-n/chmo0000470
title: mass spectrometry (MS) ()
title: InChI=1S/C11H13NO2/c1-8(13)12-11(6-7-11)9-4-2-3-5-10(9)14/h2-5,14H,6-7H2,1H3,(H,12,13)

description: dataset for mass spectrometry (MS) EI (m/z, 70 eV, 60 °C): 191 (31) [M+], 176 (34), 149 (19), 148 (100), 131 (14), 120 (31), 102 (12).HRMS (C11H13NO2): calcd 191.0946, found 191.0946.
DOI: 10.14272/xhshkwpchyitop-uhfffaoysa-n/chmo0000595
title: 13C nuclear magnetic resonance spectroscopy (13C NMR) ()
title: InChI=1S/C11H13NO2/c1-8(13)12-11(6-7-11)9-4-2-3-5-10(9)14/h2-5,14H,6-7H2,1H3,(H,12,13)

description: dataset for 13C nuclear magnetic resonance spectroscopy (13C NMR) 13C NMR (101 MHz, CDCl3, ppm) δ = 173.21 (C=O), 156.92 (CAr-OH), 131.00 (CH), 129.73 (CH), 127.11 (Cq), 119.40 (CH), 117.92 (CH), 31.94 (HNC(CH2)2), 22.78 (CH3), 15.71 (CH2, 2C).
DOI: 10.14272/xhshkwpchyitop-uhfffaoysa-n/chmo0000596
title: distortionless enhancement with polarization transfer (DEPT) ()
title: InChI=1S/C11H13NO2/c1-8(13)12-11(6-7-11)9-4-2-3-5-10(9)14/h2-5,14H,6-7H2,1H3,(H,12,13)

description: dataset for distortionless enhancement with polarization transfer (DEPT) 13C NMR (100 MHz, CDCl3, ppm) δ = 131.0, 129.7, 119.4, 117.9, 117.9.
DOI: 10.14272/xhshkwpchyitop-uhfffaoysa-n/chmo0000596.1
title: distortionless enhancement with polarization transfer (DEPT) ()
title: InChI=1S/C11H13NO2/c1-8(13)12-11(6-7-11)9-4-2-3-5-10(9)14/h2-5,14H,6-7H2,1H3,(H,12,13)

description: dataset for distortionless enhancement with polarization transfer (DEPT) 13C NMR (101 MHz, CDCl3, ppm) δ = 131.0 (+), 129.7 (+), 119.4 (+), 117.9 (+), 22.8 (+), 15.7 (–).
DOI: 10.14272/xhshkwpchyitop-uhfffaoysa-n/chmo0000630
title: infrared absorption spectroscopy (IR) ()
title: InChI=1S/C11H13NO2/c1-8(13)12-11(6-7-11)9-4-2-3-5-10(9)14/h2-5,14H,6-7H2,1H3,(H,12,13)

description: dataset for infrared absorption spectroscopy (IR) IR (ATR, ṽ) = 3286 (m), 3063 (w), 3009 (w), 2929 (w), 2859 (w), 2754 (w), 2721 (w), 2689 (w), 2604 (w), 2480 (w), 1632 (s), 1579 (s), 1541 (s), 1489 (s), 1469 (m), 1421 (vs), 1375 (s), 1324 (w), 1303 (m), 1292 (vs), 1245 (vs), 1154 (w), 1125 (w), 1086 (w), 1064 (vw), 1033 (s), 1016 (w), 972 (vw), 938 (w), 882 (w), 836 (w), 790 (m), 775 (w), 751 (vs), 703 (s), 632 (w), 612 (vs), 574 (s), 564 (m), 552 (s), 496 (vs), 446 (w), 404 (w), 375 (vw) cm–1.
DOI: 10.14272/xhshkwpchyitop-uhfffaoysa-n/chmo0000593
title: 1H nuclear magnetic resonance spectroscopy (1H NMR) ()
title: InChI=1S/C11H13NO2/c1-8(13)12-11(6-7-11)9-4-2-3-5-10(9)14/h2-5,14H,6-7H2,1H3,(H,12,13)

description: dataset for 1H nuclear magnetic resonance spectroscopy (1H NMR) 1H NMR (400 MHz, CDCl3, ppm) δ = 10.14 (s, 1H), 7.19 (ddd, J = 15.4 Hz, J = 7.6 Hz, J = 1.7 Hz, 2H), 6.91 (dd, J = 8.1 Hz, J = 1.2 Hz, 1H), 6.80 (td, J = 7.4 Hz, J = 1.3 Hz, 1H), 6.69–6.50 (m, 1H), 1.93 (s, 3H), 1.29–1.24 (m, 2H), 1.22–1.17 (m, 2H).
DOI: 10.15468/eb2gfn
title: Twenty more new species of Agrilus (Coleoptera: Buprestidae: Agrilinae) from the Oriental region

description: This dataset contains the digitized treatments in Plazi based on the original journal article Jendek, Eduard, Grebennikov, Vasily V. (2019): Twenty more new species of Agrilus (Coleoptera: Buprestidae: Agrilinae) from the Oriental region. Zootaxa 4564 (2): 449-469, DOI: https://doi.org/10.11646/zootaxa.4564.2.7
DOI: 10.25422/azu.data.11977818
title: Survey questions and responses for Next-Generation Sonoran Desert researchers Border Survey

description: /data.zip: N-Gen Border Survey data (questions and responses) in .csv and .xls format. <br><br>/consent_recruitment.zip: contains consent forms and recruitment materials in English and Spanish. <br>The U.S.-Mexico border is a region of significant biological and cultural diversity that is of interest to scientists from a wide variety of disciplines. It is also an area of humanitarian crisis and contentious politics. U.S. and Mexican researchers who conduct fieldwork on both sides of the border are faced with ethical and logistical challenges in the course of their daily work. In our study, we find that researchers are faced with challenges ranging from difficulty in obtaining permits and accessing lands in border regions, to fear and intimidation along the militarized zones. Despite many having had direct experiences that affect their safety, most researchers feel safe working in the region and adapt their behavior by staying away from risky places. However, in the midst of a humanitarian crisis, the research community is left caught in the middle when their work intersects with civil and human rights.<br>We present survey data that examines of the effects of U.S. Border policies on scientific research, specifically those researchers conducting fieldwork on both sides of the U.S.-Mexican border. While anecdotal accounts exist, we present the first quantifiable data on this subject and document the interactions that field researchers have with authorities and people crossing the U.S.-Mexico border, and the impacts that these interactions have on their ability to conduct research<br>This study was approved by an Institutional Review Board responsible for human subjects research at The University of Arizona; IRB# 1901268217. Data made available under the Creative Commons has respondents' individual comments redacted to protect participant identity, however, parties interested in collaborating on use of the full dataset may contact the authors at nextgensd@gmail.com.<br> <i>For inquiries regarding the contents of this dataset, please contact the Corresponding Author listed in the README.txt file. Administrative inquiries (e.g., removal requests, trouble downloading, etc.) can be directed to data-management@arizona.edu</i><br>
DOI: 10.15468/hlnlul
title: Secondary homonymy in Bryozoa: the case of Reteporella jullieni (Cheilostomatida)

description: This dataset contains the digitized treatments in Plazi based on the original journal article Souto. J. (2019): Secondary homonymy in Bryozoa: the case of Reteporella jullieni (Cheilostomatida). Zootaxa 4565 (2): 292-300, DOI: https://doi.org/10.11646/zootaxa.4565.2.13
DOI: 10.5281/zenodo.3713210
title: Data set: Resource footprints, quality of life and economic development

description: This data set accompanies the publication "Towards a comprehensive framework of the relationships between resource footprints, quality of life and economic development" by Stefan Cibulka and Stefan Giljum from the Institute for Ecological Economics at the Vienna University of Economics and Business (WU). The file provides data on resource footprints (carbon footprint, material footprint), Human Development Index, Happiness Index as well as GDP for countries world-wide in the time span from 1990 to 2015. In addition, it provides all specifications of the regression analyses undertaken in the course of this study and the detailed regression results.
DOI: 10.5281/zenodo.3713211
title: Data set: Resource footprints, quality of life and economic development

description: This data set accompanies the publication "Towards a comprehensive framework of the relationships between resource footprints, quality of life and economic development" by Stefan Cibulka and Stefan Giljum from the Institute for Ecological Economics at the Vienna University of Economics and Business (WU). The file provides data on resource footprints (carbon footprint, material footprint), Human Development Index, Happiness Index as well as GDP for countries world-wide in the time span from 1990 to 2015. In addition, it provides all specifications of the regression analyses undertaken in the course of this study and the detailed regression results.
DOI: 10.5281/zenodo.3713486
title: Demeter Inputs for Chen et al. 2020

description: These are the inputs used in Demeter runs for the Chen et al. 2020 submission "Global land use projections for 2015-2100 at 0.05-degree resolution under diverse Shared Socioeconomic Pathways and Representative Concentration Pathways." The input structure is described in detail in: Vernon, C.R., Le Page, Y., Chen, M., Huang, M., Calvin, K.V., Kraucunas, I.P. and Braun, C.J., 2018. Demeter – A Land Use and Land Cover Change Disaggregation Model. <em>Journal of Open Research Software</em>, 6(1), p.15. DOI: http://doi.org/10.5334/jors.208 Configuration files were created for each run and are contained in the "config_files" directory.
description: {"references": ["Vernon, C.R., Le Page, Y., Chen, M., Huang, M., Calvin, K.V., Kraucunas, I.P. and Braun, C.J., 2018. Demeter \u2013 A Land Use and Land Cover Change Disaggregation Model. Journal of Open Research Software, 6(1), p.15. DOI: http://doi.org/10.5334/jors.208"]}
DOI: 10.5281/zenodo.3713485
title: Demeter Inputs for Chen et al. 2020

description: These are the inputs used in Demeter runs for the Chen et al. 2020 submission "Global land use projections for 2015-2100 at 0.05-degree resolution under diverse Shared Socioeconomic Pathways and Representative Concentration Pathways." The input structure is described in detail in: Vernon, C.R., Le Page, Y., Chen, M., Huang, M., Calvin, K.V., Kraucunas, I.P. and Braun, C.J., 2018. Demeter – A Land Use and Land Cover Change Disaggregation Model. <em>Journal of Open Research Software</em>, 6(1), p.15. DOI: http://doi.org/10.5334/jors.208 Configuration files were created for each run and are contained in the "config_files" directory.
description: {"references": ["Vernon, C.R., Le Page, Y., Chen, M., Huang, M., Calvin, K.V., Kraucunas, I.P. and Braun, C.J., 2018. Demeter \u2013 A Land Use and Land Cover Change Disaggregation Model. Journal of Open Research Software, 6(1), p.15. DOI: http://doi.org/10.5334/jors.208"]}
DOI: 10.5281/zenodo.3714183
title: Randomised Trial of Block and Replace versus dose titration antithyroid drug treatment in children and adolescents with thyrotoxicosis.

description: <strong>This dataset contains the study regimens for the randomised controlled trial. </strong> <strong>Context</strong> First line treatment of thyrotoxicosis in young people is thionamide antithyroid drug (ATD) in a blocking dose with levothyroxine replacement (block and replace, BR) or in a smaller dose tailored to render the patient euthyroid (dose titration, DT). <strong>Objective</strong> To determine which regimen provides more stable biochemical control. <strong>Design and setting</strong> A multi-centre phase III, open-label randomised trial comparing BR with DT in patients aged 2 to 16 years with newly diagnosed thyrotoxicosis at 15 UK centres. Patients were randomised shortly after diagnosis and treated for 3 years. The primary outcome was the percentage of serum thyroid stimulating hormone (TSH) levels in the reference range between 6 months and 3 years. Secondary outcomes included the proportion of Free thyroxine (FT4) levels in the reference range, adverse event frequency and 4y outcome (remission/relapse). <strong>Results</strong> Eighty-two patients were randomised, with details on clinical course in 81 (62 Female); 40 were allocated to BR (41 DT). Three withdrew with one ineligible. The mean percentage of serum TSH within reference range was 60·2% in BR and 63·8% in DT patients; adjusted difference 4·3%, 95% CI (-7·8 to 16·4);p=0.48. Proportions for FT4 were 79·2% in BR and 85·7% in DT patients; adjusted difference 6·8%, (-0·2 to 15·6);p=0·13. Three patients developed neutropenia – all on BR. 6 BR and 10 DT patients were in remission at 4y. <strong>Conclusion</strong> This trial has shown no evidence to suggest that BR improves biochemical stability. DT, recommended by American Thyroid Association guidelines, remains the preferred approach in this age group.