cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.29345535
title: Methylation aberrations and genomic instability synergistically drive the evolution of intrahepatic cholangiocarcinoma

description: DNA methylation and genomic instability are critical drivers of cancer initiation and malignant progression. However, the roles of methylation aberrations and genomic instability in malignant progression have not been thoroughly investigated in intrahepatic cholangiocarcinoma (ICC). To address this, we identified differentially methylated regions (DMRs) and somatic copy number alterations (SCNAs) from 341 ICC samples across various stages. Our findings revealed that stages IAIB, II, IIIA, and IIIB exhibited comparable methylation changes, whereas stage IV ICC showed a pronounced accumulation of stage-specific methylation alterations. Leveraging these findings, we developed a classification model that effectively distinguished stage IV ICC from earlier stages with high accuracy using 15 DMRs. Furthermore, stage IV ICC exhibited slightly higher genomic instability, including an elevated aneuploidy score and a greater proportion of focal amplifications. We also observed a positive correlation between SCNA burden and DNA methylation entropy in the promoter, gene body, and CpG island regions, with the gene body of <i>MDM2</i> serving as a notable example. These findings highlight the potential of DNA methylation as a biomarker for metastasis diagnosis and the interplay between local genomic instability and aberrant methylation, emphasizing their synergistic roles in driving the evolutionary trajectory of ICC. Intrahepatic cholangiocarcinoma (ICC) is a rare but aggressive type of liver cancer with a poor prognosis. In this study, we analyzed DNA methylation and genetic alterations in 341 ICC samples to understand how these molecular changes contribute to cancer progression. DNA methylation is a chemical modification to DNA that can switch genes on or off without changing the DNA sequence itself. Genomic instability, which refers to a high frequency of mutations across the genome, is a common feature of cancer. We found that abnormal DNA methylation occurs more frequently in advanced-stage ICC and can help distinguish advanced from early-stage disease, suggesting it could serve as a potential biomarker for cancer spread. We also observed greater genomic instability in advanced-stage ICC. Notably, the abnormal DNA methylation patterns were closely linked to genomic instability – especially in key cancer-related genes – potentially working together to disrupt normal gene function. Our findings provide new insights into how epigenetic and genetic alterations drive the development and progression of ICC and may support future efforts to develop new diagnostic tools or targeted treatments.
DOI: 10.6084/m9.figshare.29345535.v1
title: Methylation aberrations and genomic instability synergistically drive the evolution of intrahepatic cholangiocarcinoma

description: DNA methylation and genomic instability are critical drivers of cancer initiation and malignant progression. However, the roles of methylation aberrations and genomic instability in malignant progression have not been thoroughly investigated in intrahepatic cholangiocarcinoma (ICC). To address this, we identified differentially methylated regions (DMRs) and somatic copy number alterations (SCNAs) from 341 ICC samples across various stages. Our findings revealed that stages IAIB, II, IIIA, and IIIB exhibited comparable methylation changes, whereas stage IV ICC showed a pronounced accumulation of stage-specific methylation alterations. Leveraging these findings, we developed a classification model that effectively distinguished stage IV ICC from earlier stages with high accuracy using 15 DMRs. Furthermore, stage IV ICC exhibited slightly higher genomic instability, including an elevated aneuploidy score and a greater proportion of focal amplifications. We also observed a positive correlation between SCNA burden and DNA methylation entropy in the promoter, gene body, and CpG island regions, with the gene body of <i>MDM2</i> serving as a notable example. These findings highlight the potential of DNA methylation as a biomarker for metastasis diagnosis and the interplay between local genomic instability and aberrant methylation, emphasizing their synergistic roles in driving the evolutionary trajectory of ICC. Intrahepatic cholangiocarcinoma (ICC) is a rare but aggressive type of liver cancer with a poor prognosis. In this study, we analyzed DNA methylation and genetic alterations in 341 ICC samples to understand how these molecular changes contribute to cancer progression. DNA methylation is a chemical modification to DNA that can switch genes on or off without changing the DNA sequence itself. Genomic instability, which refers to a high frequency of mutations across the genome, is a common feature of cancer. We found that abnormal DNA methylation occurs more frequently in advanced-stage ICC and can help distinguish advanced from early-stage disease, suggesting it could serve as a potential biomarker for cancer spread. We also observed greater genomic instability in advanced-stage ICC. Notably, the abnormal DNA methylation patterns were closely linked to genomic instability – especially in key cancer-related genes – potentially working together to disrupt normal gene function. Our findings provide new insights into how epigenetic and genetic alterations drive the development and progression of ICC and may support future efforts to develop new diagnostic tools or targeted treatments.
DOI: 10.6084/m9.figshare.29083017
title: Assessment of multilingual children by Western Australian speech-language pathologists: A survey of practices, barriers and facilitators

description: In the past decade, diagnostic criteria for developmental language disorder, guidelines for assessment of multilingual children, and reviews of the diagnostic utility of dynamic assessment have been published. It is unknown how Australian speech-language pathologists currently assess multilingual children or how local factors influence assessment. A mixed-method anonymous online survey of Western Australian speech-language pathologists explored the frequency and perceived usefulness of assessment practices recommended for multilingual children, elements of dynamic assessment used, and the utility of specific client factors for diagnosis. Confidence ratings and descriptions of barriers and facilitators that affect assessment of multilingual children were also collected. Nineteen speech-language pathologists completed the survey. Over 90% used case/family history and norm-referenced assessments. They most strongly valued case history and family interviews, but fewer valued language processing tasks or language sample analysis. Over three quarters performed dynamic assessment with varying elements included. Two-thirds were confident to assess multilingual children. Interpreter access, availability of specific assessments, supportive networks, and professional development influenced assessment accuracy. The speech-language pathologists in this study combine data from various sources to assess multilingual children for developmental language disorder. Increased access to interpreter services, professional development, and additional time and resources may improve services.
DOI: 10.6084/m9.figshare.29083017.v1
title: Assessment of multilingual children by Western Australian speech-language pathologists: A survey of practices, barriers and facilitators

description: In the past decade, diagnostic criteria for developmental language disorder, guidelines for assessment of multilingual children, and reviews of the diagnostic utility of dynamic assessment have been published. It is unknown how Australian speech-language pathologists currently assess multilingual children or how local factors influence assessment. A mixed-method anonymous online survey of Western Australian speech-language pathologists explored the frequency and perceived usefulness of assessment practices recommended for multilingual children, elements of dynamic assessment used, and the utility of specific client factors for diagnosis. Confidence ratings and descriptions of barriers and facilitators that affect assessment of multilingual children were also collected. Nineteen speech-language pathologists completed the survey. Over 90% used case/family history and norm-referenced assessments. They most strongly valued case history and family interviews, but fewer valued language processing tasks or language sample analysis. Over three quarters performed dynamic assessment with varying elements included. Two-thirds were confident to assess multilingual children. Interpreter access, availability of specific assessments, supportive networks, and professional development influenced assessment accuracy. The speech-language pathologists in this study combine data from various sources to assess multilingual children for developmental language disorder. Increased access to interpreter services, professional development, and additional time and resources may improve services.
DOI: 10.15468/dl.vjrrsp
title: Occurrence Download

description: A dataset containing 19215 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Linaria vulgaris Mill.",
 "Country is United States of America",
 "HasCoordinate is true"
 ]
}

 The dataset includes 19215 records from 173 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0081157-250525065834625/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.vhfd7c
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "HasGeospatialIssue is false",
 "HasCoordinate is true",
 "OccurrenceStatus is Present",
 {
 "not" : {
 "BasisOfRecord" : [
 "is one of (Fossil, Material sample)"
 ]
 }
 },
 "TaxonKey is Lybius leucogaster (Bocage, 1877)",
 "Continent is one of (Africa)",
 "Year is greater than or equal to 1900"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0081159-250525065834625/datasets/export for details.
DOI: 10.5281/zenodo.15712735
title: Dynamic interference of chirped photoelectrons

description: Files for associated publication with DOI: 10.1103/73tl-w87y
DOI: 10.5281/zenodo.15712734
title: Dynamic interference of chirped photoelectrons

description: Files for associated publication with DOI: 10.1103/73tl-w87y
DOI: 10.15468/dl.u9zkz2
title: Occurrence Download

description: A dataset containing 36465 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Populus deltoides W.Bartram ex Marshall"
 ]
}

 The dataset includes 36465 records from 555 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0081160-250525065834625/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.b2zhu3
title: Occurrence Download

description: A dataset containing 4893 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Turpinia simplicifolia Merr., Turpinia malabarica Gamble, Turpinia picardae Urb., Turpinia montana (Blume) Kurz, Turpinia occidentalis (Sw.) G.Don, Turpinia pentandra (Schltr.) B.L.Linden, Turpinia parvifoliola L.O.Williams)",
 "HasCoordinate is true",
 "HasGeospatialIssue is false"
 ]
}

 The dataset includes 4893 records from 213 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0081162-250525065834625/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.25549/inscriptifact-ouc111114976
title: Temple administrative record, UT 1599-13

description: [Text Description:] Temple administrative record. ❧ [Text or Publication Number Note:] UT 1599-13 ❧ [Excavation Description:] Jokha ❧ [Medium:] Clay ❧ [Script Note:] Cuneiform, Non-Alphabetic ❧ [Physical Object Description:] Square clay tablet, pinkish-orange color, reverse has white band through middle. LABEL: "1599" in black ink, "13" in red ink (matched paint?). 4.5 x 4cm. ❧ [Physical Object Note:] Reign of Shu-Sin, fourth dynastic king.
DOI: 10.15468/dl.urdr7m
title: Occurrence Download

description: A dataset containing 47 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Eptesicus gobiensis Bobrinskii, 1926",
 "HasCoordinate is true",
 "Year is greater than or equal to 2011",
 "Year is less than or equal to 2024"
 ]
}

 The dataset includes 47 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0061919-240506114902167/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.25549/inscriptifact-ouc111115013
title: Temple administrative record, UT 1599-13

description: [Text Description:] Temple administrative record. ❧ [Text or Publication Number Note:] UT 1599-13 ❧ [Excavation Description:] Jokha ❧ [Medium:] Clay ❧ [Script Note:] Cuneiform, Non-Alphabetic ❧ [Physical Object Description:] Square clay tablet, pinkish-orange color, reverse has white band through middle. LABEL: "1599" in black ink, "13" in red ink (matched paint?). 4.5 x 4cm. ❧ [Physical Object Note:] Reign of Shu-Sin, fourth dynastic king.
DOI: 10.25549/inscriptifact-ouc111115141
title: Temple administrative record, UT 1599-13

description: [Text Description:] Temple administrative record. ❧ [Text or Publication Number Note:] UT 1599-13 ❧ [Excavation Description:] Jokha ❧ [Medium:] Clay ❧ [Script Note:] Cuneiform, Non-Alphabetic ❧ [Physical Object Description:] Square clay tablet, pinkish-orange color, reverse has white band through middle. LABEL: "1599" in black ink, "13" in red ink (matched paint?). 4.5 x 4cm. ❧ [Physical Object Note:] Reign of Shu-Sin, fourth dynastic king.
DOI: 10.25549/inscriptifact-ouc1sto1652688
title: InscriptiFact -- an image database of inscriptions and artifacts
DOI: 10.25549/inscriptifact-ouc111113001
title: Butcher's bill, UT 1599-9

description: [Text Description:] Butcher's bill: sheep, lamb. ❧ [Text or Publication Number Note:] UT 1599-9 ❧ [Excavation Description:] Drehem ❧ [Medium:] Clay ❧ [Script Note:] Cuneiform, Non-Alphabetic ❧ [Physical Object Description:] Small clay tablet, pink-orange color. LABEL: "1599" in black ink, "9" + underscore in red ink. 2 x 2.5cm. ❧ [Physical Object Note:] Reign of Shulgi, second dynastic king.
DOI: 10.25549/inscriptifact-ouc111113021
title: Butcher's bill, UT 1599-9

description: [Text Description:] Butcher's bill: sheep, lamb. ❧ [Text or Publication Number Note:] UT 1599-9 ❧ [Excavation Description:] Drehem ❧ [Medium:] Clay ❧ [Script Note:] Cuneiform, Non-Alphabetic ❧ [Physical Object Description:] Small clay tablet, pink-orange color. LABEL: "1599" in black ink, "9" + underscore in red ink. 2 x 2.5cm. ❧ [Physical Object Note:] Reign of Shulgi, second dynastic king.
DOI: 10.15468/dl.xzpgdj
title: Occurrence Download

description: A dataset containing 222 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Cirsium italicum DC."
 ]
}

 The dataset includes 222 records from 25 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0014455-190621201848488/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.25549/inscriptifact-ouc111113022
title: Butcher's bill, UT 1599-9

description: [Text Description:] Butcher's bill: sheep, lamb. ❧ [Text or Publication Number Note:] UT 1599-9 ❧ [Excavation Description:] Drehem ❧ [Medium:] Clay ❧ [Script Note:] Cuneiform, Non-Alphabetic ❧ [Physical Object Description:] Small clay tablet, pink-orange color. LABEL: "1599" in black ink, "9" + underscore in red ink. 2 x 2.5cm. ❧ [Physical Object Note:] Reign of Shulgi, second dynastic king.
DOI: 10.25549/inscriptifact-ouc111113023
title: Butcher's bill, UT 1599-9

description: [Text Description:] Butcher's bill: sheep, lamb. ❧ [Text or Publication Number Note:] UT 1599-9 ❧ [Excavation Description:] Drehem ❧ [Medium:] Clay ❧ [Script Note:] Cuneiform, Non-Alphabetic ❧ [Physical Object Description:] Small clay tablet, pink-orange color. LABEL: "1599" in black ink, "9" + underscore in red ink. 2 x 2.5cm. ❧ [Physical Object Note:] Reign of Shulgi, second dynastic king.
DOI: 10.15468/dl.fv2rn6
title: Occurrence Download

description: A dataset containing 236 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Geometry POLYGON((-79.45415852911138 -2.349881733329983,-78.04268569069639 -2.349881733329983,-78.04268569069639 -0.938408894914978,-79.45415852911138 -0.938408894914978,-79.45415852911138 -2.349881733329983))",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 "TaxonKey is Sicalis flaveola (Linnaeus, 1766)"
 ]
}

 The dataset includes 236 records from 2 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0264943-210914110416597/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.25549/inscriptifact-ouc111113461
title: Butcher's bill, UT 1599-10

description: [Text Description:] Butcher's bill: sheep, goat, lamb. ❧ [Text or Publication Number Note:] UT 1599-10 ❧ [Excavation Description:] Drehem ❧ [Medium:] Clay ❧ [Script Note:] Cuneiform, Non-Alphabetic ❧ [Physical Object Description:] Small clay tablet, beige-brown color. LABEL: "1599" in pencil, "10" in black ink. 2 x 2cm.
DOI: 10.15468/dl.eh4pzw
title: Occurrence Download

description: A dataset containing 228 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is South Africa",
 "Geometry POLYGON((30.63632 -26.09435,32.08847 -26.09435,32.08847 -22.2982,30.63632 -22.2982,30.63632 -26.09435))",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 "TaxonKey is Colophospermum mopane (J.Kirk ex Benth.) J.Léonard"
 ]
}

 The dataset includes 228 records from 8 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0061920-240506114902167/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.25549/inscriptifact-ouc111353907
title: List, PNN, KTU 4.628

description: [Text Description:] Ugaritic Tablet KTU 4.628 ❧ [Text or Publication Number Note:] KTU 4.628; KTU2 4.628; KTU3 4.628; CTU 4.628; CAT 4.628; RS 19.060; DO 5047 ❧ [Excavation Description:] Found during excavations at Ras Shamra. ❧ [Medium:] Clay ❧ [Script Note:] Alphabetic Cuneiform
DOI: 10.15468/dl.2qgt4j
title: Occurrence Download

description: A dataset containing 1767 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Marsilea quadrifolia L., Salvinia ×molesta D.S.Mitch.)",
 "Geometry POLYGON((-9.36035 44.71551,-10.59082 42.81152,-11.82129 36.80928,-7.69043 36.17336,-3.38379 35.88905,3.12012 38.13456,9.18457 38.20366,11.7334 37.16032,12.78809 34.74161,17.09473 33.79741, 23.15918 34.23451,30.10254 32.62087,33.2666 32.99024,35.72754 35.03,33.00293 35.53223,28.69629 35.17381,28.34473 36.31513,25.7959 37.50973,24.91699 39.90974,28.78418 40.6473,30.71777 41.17865,36.87012 45.213,38.18848 46.98025,38.71582 47.7541,39.94629 47.93107,40.20996 49.61071,37.0459 50.34546,35.72754 50.40152,33.79395 52.26816,31.68457 51.94426,31.4209 53.27835,32.56348 53.43572,30.98145 54.77535,30.89355 55.52863,28.43262 56.02295,27.20215 57.65716,27.37793 58.30949,27.90527 59.17593,29.66309 59.88894,27.6416 60.58697,31.50879 62.75473,28.78418 69.83962,30.89355 70.28912,29.22363 71.55274,21.75293 71.30079,14.28223 70.14036,11.38184 67.47492,4.87793 63.66576,-5.53711 71.52491,-10.63477 71.69129,-21.5332 67.74276,-28.56445 65.36684,-24.3457 61.35461,-9.36035 44.71551))",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "Year is greater than or equal to 1980",
 "Year is less than or equal to 2021"
 ]
}

 The dataset includes 1767 records from 60 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0163228-210914110416597/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.25549/inscriptifact-ouc111354010
title: List, PNN, KTU 4.628

description: [Text Description:] Ugaritic Tablet KTU 4.628 ❧ [Text or Publication Number Note:] KTU 4.628; KTU2 4.628; KTU3 4.628; CTU 4.628; CAT 4.628; RS 19.060; DO 5047 ❧ [Excavation Description:] Found during excavations at Ras Shamra. ❧ [Medium:] Clay ❧ [Script Note:] Alphabetic Cuneiform
DOI: 10.25549/inscriptifact-ouc111353992
title: Record, KTU 4.627

description: [Text Description:] Ugaritic Tablet KTU 4.627 ❧ [Text or Publication Number Note:] KTU 4.627; KTU2 4.627; KTU3 4.627; CTU 4.627; CAT 4.627; RS 19.058; DO 5045 ❧ [Excavation Description:] Found during excavations at Ras Shamra. ❧ [Medium:] Clay ❧ [Script Note:] Alphabetic Cuneiform
DOI: 10.15468/dl.2ybkm6
title: Occurrence Download

description: A dataset containing 4592 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Dryopteris remota (A.Braun ex Döll) Druce, Sceptridium multifidum (S.G.Gmel.) M.Nishida ex Tagawa)",
 "Geometry POLYGON((-9.36035 44.71551,-10.59082 42.81152,-11.82129 36.80928,-7.69043 36.17336,-3.38379 35.88905,3.12012 38.13456,9.18457 38.20366,11.7334 37.16032,12.78809 34.74161,17.09473 33.79741, 23.15918 34.23451,30.10254 32.62087,33.2666 32.99024,35.72754 35.03,33.00293 35.53223,28.69629 35.17381,28.34473 36.31513,25.7959 37.50973,24.91699 39.90974,28.78418 40.6473,30.71777 41.17865,36.87012 45.213,38.18848 46.98025,38.71582 47.7541,39.94629 47.93107,40.20996 49.61071,37.0459 50.34546,35.72754 50.40152,33.79395 52.26816,31.68457 51.94426,31.4209 53.27835,32.56348 53.43572,30.98145 54.77535,30.89355 55.52863,28.43262 56.02295,27.20215 57.65716,27.37793 58.30949,27.90527 59.17593,29.66309 59.88894,27.6416 60.58697,31.50879 62.75473,28.78418 69.83962,30.89355 70.28912,29.22363 71.55274,21.75293 71.30079,14.28223 70.14036,11.38184 67.47492,4.87793 63.66576,-5.53711 71.52491,-10.63477 71.69129,-21.5332 67.74276,-28.56445 65.36684,-24.3457 61.35461,-9.36035 44.71551))",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "Year is greater than or equal to 1980",
 "Year is less than or equal to 2021"
 ]
}

 The dataset includes 4592 records from 92 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0163224-210914110416597/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.25549/inscriptifact-ouc111286657
title: Incised jar fragment, IAA 96-1778

description: [Text Description:] Lightly scratched letters ❧ [Text or Publication Number Note:] IAA 96-1778 ❧ [Medium:] Clay ❧ [Script Note:] Hebrew ❧ [Physical Object Description:] Incised jar fragment ❧
DOI: 10.25549/inscriptifact-ouc111287482
title: Incised jar fragment, IAA 96-3375

description: [Text Description:] Parts of 2 or 3 letters ❧ [Text or Publication Number Note:] IAA 96-3375 ❧ [Medium:] Clay ❧ [Script Note:] Hebrew ❧ [Physical Object Description:] Incised jar fragment ❧
DOI: 10.15468/dl.dr9gns
title: Occurrence Download

description: A dataset containing 8014 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Geometry POLYGON((-25.49138 -4.10255,32.49138 -4.10255,32.49138 19.10255,-25.49138 19.10255,-25.49138 -4.10255))",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 "TaxonKey is Detarium microcarpum Guill. & Perr."
 ]
}

 The dataset includes 8014 records from 83 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0163211-210914110416597/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.