cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.7814405.v3
title: Data from Sphingosine kinase and sphingosine-1-phosphate regulate epithelial cell architecture by the modulation of de novo sphingolipid synthesis

description: Sphingolipids regulate several aspects of cell behavior and it has been demonstrated that cells adjust their sphingolipid metabolism in response to metabolic needs. Particularly, sphingosine-1-phosphate (S1P), a final product of sphingolipid metabolism, is a potent bioactive lipid involved in the regulation of various cellular processes, including cell proliferation, cell migration, actin cytoskeletal reorganization and cell adhesion. In previous work in rat renal papillae, we showed that sphingosine kinase (SK) expression and S1P levels are developmentally regulated and control de novo sphingolipid synthesis. The aim of the present study was to evaluate the participation of SK/S1P pathway in the triggering of cell differentiation by external hypertonicity. We found that hypertonicity evoked a sharp decrease in SK expression, thus activating the de novo sphingolipid synthesis pathway. Furthermore, the inhibition of SK activity evoked a relaxation of cell-cell adherens junction (AJ) with accumulation of the AJ complex (E-cadherin/β-catenin/α-catenin) in the Golgi complex, preventing the acquisition of the differentiated cell phenotype. This phenotype alteration was a consequence of a sphingolipid misbalance with an increase in ceramide levels. Moreover, we found that SNAI1 and SNAI2 were located in the cell nucleus with impairment of cell differentiation induced by SK inhibition, a fact that is considered a biochemical marker of epithelial to mesenchymal transition. So, we suggest that the expression and activity of SK1, but not SK2, act as a control system, allowing epithelial cells to synchronize the various branches of sphingolipid metabolism for an adequate cell differentiation program.
DOI: 10.6084/m9.figshare.7814345
title: random media microstructures, https://arxiv.org/abs/1902.03968, sec. 3.3

description: Random media of nonoverlapping polydisperse spheres
DOI: 10.6084/m9.figshare.7814378
title: Litocholla globosa SnPLi videos

description: Videos showing culture of Lithocolla globosa
DOI: 10.6084/m9.figshare.7814378.v1
title: Litocholla globosa SnPLi videos

description: Videos showing culture of Lithocolla globosa
DOI: 10.6084/m9.figshare.7814405.v2
title: Data from Sphingosine kinase and sphingosine-1-phosphate regulate epithelial cell architecture by the modulation of de novo sphingolipid synthesis

description: Sphingolipids regulate several aspects of cell behavior and it has been demonstrated that cells adjust their sphingolipid metabolism in response to metabolic needs. Particularly, sphingosine-1-phosphate (S1P), a final product of sphingolipid metabolism, is a potent bioactive lipid involved in the regulation of various cellular processes, including cell proliferation, cell migration, actin cytoskeletal reorganization and cell adhesion. In previous work in rat renal papillae, we showed that sphingosine kinase (SK) expression and S1P levels are developmentally regulated and control de novo sphingolipid synthesis. The aim of the present study was to evaluate the participation of SK/S1P pathway in the triggering of cell differentiation by external hypertonicity. We found that hypertonicity evoked a sharp decrease in SK expression, thus activating the de novo sphingolipid synthesis pathway. Furthermore, the inhibition of SK activity evoked a relaxation of cell-cell adherens junction (AJ) with accumulation of the AJ complex (E-cadherin/β-catenin/α-catenin) in the Golgi complex, preventing the acquisition of the differentiated cell phenotype. This phenotype alteration was a consequence of a sphingolipid misbalance with an increase in ceramide levels. Moreover, we found that SNAI1 and SNAI2 were located in the cell nucleus with impairment of cell differentiation induced by SK inhibition, a fact that is considered a biochemical marker of epithelial to mesenchymal transition. So, we suggest that the expression and activity of SK1, but not SK2, act as a control system, allowing epithelial cells to synchronize the various branches of sphingolipid metabolism for an adequate cell differentiation program.
DOI: 10.25376/hra.7814324
title: Zhang et al, final, PMID29330215 .full.pdf

description: Our data suggest that increased levels of miR-195 in failing myocardium regulate a novel pathway that involves direct SIRT3 suppression and enzymatic inhibition via increased acetylation of PDH and ATP synthase that are essential for cardiac energy metabolism
DOI: 10.6084/m9.figshare.7814315
title: Original data of the article

description: Original data of the article<br>
DOI: 10.25376/hra.7814324.v1
title: Zhang et al, final, PMID29330215 .full.pdf

description: Our data suggest that increased levels of miR-195 in failing myocardium regulate a novel pathway that involves direct SIRT3 suppression and enzymatic inhibition via increased acetylation of PDH and ATP synthase that are essential for cardiac energy metabolism
DOI: 10.6084/m9.figshare.7814312
title: Hydrological Balance Laguna de Santiaguillo Basin1.xlsx

description: Data base that contain the calculations of the hydrologycal balance of Cuenca de la Laguna de Santiaguillo, using the criterial given in the 11-Nom of CONAGUA<br>
DOI: 10.6084/m9.figshare.7814315.v1
title: Original data of the article

description: Original data of the article<br>
DOI: 10.6084/m9.figshare.7814297
title: random media meshes, https://arxiv.org/abs/1902.03968, sec. 3.3

description: Triangular 2d finite element meshes with polydisperse nonoverlapping spherical exclusions
DOI: 10.6084/m9.figshare.7814309
title: Nuclearia cultures datasets

description: THIS DATA MAY CONTAIN CONTAMINATION AND MISSASSEMBLIES. <b>VERSION V0</b>. IT WILL BE UPDATED SOON.<br><br>RNAseq data from two distinct <i>Nuclearia</i> species; published in: 10.1098/rstb.2019.0094. Combined cultivation and single-cell approaches to the phylogenomics of nucleariid amoebae, close relatives of fungi.<br>Nuclearia delicatula MK547177 and Nuclearia thermophila MK547178 come from the culture collection Sciento (UK), which has maintained with Oscillatoria-like filamentous cyanobacteria, in freshwater medium BG11 for several years and the origin of them is unclear, but from freshwater spring near Manchester. Both species were isolated from the same JP100 culture between 2014 and 2016. Nuclearia delicatula was first isolated by culture transfer, although with the presence of a Poterioochromonas-like (stramenopile) and an Echinamoeba-like (amoebozoan) contaminants. Nuclearia thermophila was later isolated from JP100 culture with the Eppendorf PatchMan NP2 micromanipulator using a 110 µm VacuTip microcapillary (Eppendorf) in an inverted microscope Leica Dlll3000 B.<br>RNAseq and assembly as in materials and methods and supplementary material of the aforementioned article.<br>
DOI: 10.6084/m9.figshare.7814246
title: GlobalEssentialMedicinesDatabase.xlsx

description: <b>Global Essential Medicines Database</b><b><br></b> In June of 2017, we searched the WHO Essential Medicines and Health Products Information Portal, an online repository that contains hundreds of publication on medicines and health products related to WHO priorities, and a full-section dedicated to national essential medicines lists (EMLs). A WHO information specialist actively searched for updated versions of national EMLs, including national formularies, reimbursement lists, and lists based on standard treatment guidelines. <br>We included all national EMLs that were posted on the WHO’s NEMLs Repository irrespective of publication date and language. When we found more than one national EML from the same country, we used the most recent. We excluded documents that were not EMLs, such as prescribing guidelines. We also included the 20th edition of the WHO Model EML (2017) in this database. <br>From each EML we abstracted medicines using International Nonproprietary Names (INNs). For medicines whose names were not in English we used the Anatomical Therapeutic Chemical (ATC) classification system, if available, or translated the names with the help of Google Translate. We listed each medicine individually, whether it was part of a combination product or not. We treated as the same medicine bases and their salts (e.g. promethazine hydrochloride and promethazine) as well as different compounds of the same vitamin or mineral (e.g. ferrous fumarate and ferrous sulfate). We excluded diagnostic agents, antiseptics, disinfectants, and saline solutions.<br> In this database "1" and "0" indicate the presence or absence of the medicine respectively on an EML.
DOI: 10.6084/m9.figshare.7814186
title: random media meshes - to be deleted!

description: FEM triangular mesh with random polydisperse spherical exclusions<br>
DOI: 10.6084/m9.figshare.7814186.v1
title: random media meshes

description: FEM triangular mesh with random polydisperse spherical exclusions<br>
DOI: 10.6084/m9.figshare.7814147
title: mesh0.mat - to be deleted!

description: Finite element mesh for random heterogeneous media<br>
DOI: 10.6084/m9.figshare.7814186.v3
title: random media meshes

description: FEM triangular mesh with random polydisperse spherical exclusions<br>
DOI: 10.6084/m9.figshare.7814009
title: Coppicing and plant diversity in a lowland wood remnant in North–East Italy

description: In European lowlands, remnants of natural forests are rare, small, fragmented and often endangered. Most of the recent EU environmental policies have included such habitats in protected areas. However, nature conservation measures may conflict with traditional forest management, such as coppicing. We used a space-for-time approach to assess the effect of two contrasting silvicultural practices (coppicing vs. conversion to high forest) on composition and structure of plant community. Plant diversity was calculated as overall and single vegetation layer value. Functional diversity was evaluated in terms of functional richness, evenness and divergence. Our findings showed that coppice age has a strong effect on taxonomical and functional diversities, which generally decreased from young to mature stands. Species composition was significantly changed with coppice age and after the conversion to high forest, showing that traditional coppicing may contribute to sustaining habitat heterogeneity and key <i>taxa</i> for nature conservation. The abandonment of coppicing in the area might lead to a general landscape and habitat simplification, a weakening of the system functions and the loss of crucial species.
DOI: 10.6084/m9.figshare.7814009.v1
title: Coppicing and plant diversity in a lowland wood remnant in North–East Italy

description: In European lowlands, remnants of natural forests are rare, small, fragmented and often endangered. Most of the recent EU environmental policies have included such habitats in protected areas. However, nature conservation measures may conflict with traditional forest management, such as coppicing. We used a space-for-time approach to assess the effect of two contrasting silvicultural practices (coppicing vs. conversion to high forest) on composition and structure of plant community. Plant diversity was calculated as overall and single vegetation layer value. Functional diversity was evaluated in terms of functional richness, evenness and divergence. Our findings showed that coppice age has a strong effect on taxonomical and functional diversities, which generally decreased from young to mature stands. Species composition was significantly changed with coppice age and after the conversion to high forest, showing that traditional coppicing may contribute to sustaining habitat heterogeneity and key <i>taxa</i> for nature conservation. The abandonment of coppicing in the area might lead to a general landscape and habitat simplification, a weakening of the system functions and the loss of crucial species.
DOI: 10.6084/m9.figshare.7813916
title: Source Data Figure 7 .xlsx

description: <b>a</b>, <i>Sod3</i>, collagen type II alpha 1 chain (<i>Col2a1</i>), aggrecan (<i>Acan</i>), proteoglycan 4 (<i>Prg4</i>), and SRY-box 9 (<i>Sox9</i>) mRNA levels in interleukin 1 beta ( IL1β, 10 ng ml<sup>-1</sup>)-induced rat osteoarthritis (OA) chondrocytes cultured with BNTA (0.1 μM) or three siSOD3s for 6 h, respectively (n = 6 for each group; <i>Sod3</i>, <i>Prg4</i>, one-way ANOVA; <i>Col2a1</i>, <i>Acan</i>, <i>Sox9</i>, nonparametric test).<b> c</b>, <i>Sod3</i>, <i>Col2a1</i>, <i>Acan</i>, <i>Prg4</i>, and <i>Sox9 </i>mRNA levels in IL1β (10 ng ml<sup>-1</sup>)-induced rat OA chondrocytes treated with vehicle or SOD3 plasmid for 2 d (n = 6 for each group;<i> Sod3</i>, <i>Acan</i>, and <i>Sox9, </i>unpaired two-tailed Student’s <i>t</i>-test; <i>Col2a1</i> and<i> Prg4, </i>nonparametric test). Data are shown as the mean ± standard deviation (s. d.). *<i>P</i> &lt; 0.05, **<i>P</i> &lt; 0.01, ***<i>P</i> &lt; 0.001.
DOI: 10.6084/m9.figshare.7813940
title: Table01_Ecuador_Volcanoes_Chiaradia.xlsx

description: Geochemical and radiogenic isotope data of volcanic edifices of Ecuador and southernmost Colombia
DOI: 10.6084/m9.figshare.7813916.v1
title: Source Data Figure 7 .xlsx

description: <b>a</b>, <i>Sod3</i>, collagen type II alpha 1 chain (<i>Col2a1</i>), aggrecan (<i>Acan</i>), proteoglycan 4 (<i>Prg4</i>), and SRY-box 9 (<i>Sox9</i>) mRNA levels in interleukin 1 beta ( IL1β, 10 ng ml<sup>-1</sup>)-induced rat osteoarthritis (OA) chondrocytes cultured with BNTA (0.1 μM) or three siSOD3s for 6 h, respectively (n = 6 for each group; <i>Sod3</i>, <i>Prg4</i>, one-way ANOVA; <i>Col2a1</i>, <i>Acan</i>, <i>Sox9</i>, nonparametric test).<b> c</b>, <i>Sod3</i>, <i>Col2a1</i>, <i>Acan</i>, <i>Prg4</i>, and <i>Sox9 </i>mRNA levels in IL1β (10 ng ml<sup>-1</sup>)-induced rat OA chondrocytes treated with vehicle or SOD3 plasmid for 2 d (n = 6 for each group;<i> Sod3</i>, <i>Acan</i>, and <i>Sox9, </i>unpaired two-tailed Student’s <i>t</i>-test; <i>Col2a1</i> and<i> Prg4, </i>nonparametric test). Data are shown as the mean ± standard deviation (s. d.). *<i>P</i> &lt; 0.05, **<i>P</i> &lt; 0.01, ***<i>P</i> &lt; 0.001.
DOI: 10.6084/m9.figshare.7813910
title: Source Data Figure 6 .xlsx

description: <b>c</b>, Quantification of mRNA levels for <i>Sod3 </i>in articular cartilage tissue of rat OA model after vehicle or BNTA (1.5 mg kg<sup>-1</sup>) treatment for 4 w (nonparametric test; n = 5 for each group), <i>SOD3</i> in human OA cartilage explants after vehicle or BNTA (0.1 μM) treatment for 3 w (unpaired two-tailed Student’s <i>t</i>-test; n = 5 for each group), and <i>Sod3</i> in interleukin 1 beta ( IL1β, 10 ng ml<sup>-1</sup>)-induced rat OA chondrocytes after BNTA or vehicle treatment for 6 h (nonparametric test; n = 6 for each group). <b>d,</b> The extracellular and intracellular SOD activities in rat primary chondrocytes after treated with IL1β (10 ng ml<sup>-1</sup>) or BNTA (0.1 μM) for 3 d (one-way ANOVA; n = 6 for each group).<b> e, </b>The ability to produce superoxide anions of culture media in IL1β (10 ng ml<sup>-1</sup>)-induced rat OA chondrocytes incubated with BNTA (0.1 μM) for 2 d and 3 d, which was used to assess the extracellular superoxide anions content (one-way ANOVA; n = 6 for each group).<b> g, </b>Quantitative assay of superoxide anions in IL1β (10 ng ml<sup>-1</sup>)-induced rat OA chondrocytes incubated with BNTA (0.1 μM) for 2 d, as assessed with MitoSOX Red staining (one-way ANOVA; n = 24 for each group). Scale bar, 25 μm. Data are shown as the mean ± standard deviation (s. d.). *<i>P</i> &lt; 0.05, **<i>P</i> &lt; 0.01, ***<i>P</i> &lt; 0.001.
DOI: 10.6084/m9.figshare.7813907
title: Source Data Figure 4 .xlsx

description: <b>a-b</b>, Quantification of mRNA levels for collagen type II alpha 1 chain (<i>Col2a1</i>), aggrecan<i> </i>(<i>Acan</i>), SRY-box 9 (<i>Sox9</i>), proteoglycan 4 (<i>Prg4</i>), C-C motif chemokine ligand 2 (<i>Ccl2</i>), interleukin (<i>Il</i>)<i>11</i>, <i>Il6</i>, ADAM metallopeptidase with thrombospondin type 1 motif (<i>Adamts</i>)<i>1</i>, <i>Adamts5</i>, matrix metalloproteinase (<i>Mmp</i>)<i>3,</i> and <i>Mmp13</i> in articular cartilage obtained from sham, vehicle, and BNTA-treated (1.5 mg kg<sup>-1</sup>) rats at 4 w and 8 w (a, <i>Col2a1</i>, <i>Acan,</i> <i>Sox9</i>, <i>Prg4, Adamts5</i>,<i> Ccl2</i>, <i>Il11</i>, <i>Il6</i>,<i> </i>and<i> Mmp3, </i>one-way ANOVA; <i>Adamts1</i> and <i>Mmp13, </i>nonparametric test; b, <i>Acan</i>, <i>Sox9</i>, <i>Prg4</i>, <i>Il11</i>, and <i>Mmp13, </i>one-way ANOVA; <i>Col2a1</i>, <i>Ccl2, Il6</i>, <i>Adamts1</i>, <i>Adamts5,</i> and <i>Mmp3, </i>nonparametric test; n = 5 for each group). <b>c</b>, Biomechanical properties of cartilage samples from sham, vehicle, and BNTA-treated (1.5 mg kg<sup>-1</sup>) rats at 4 w assessed using a nanoindentation test (n = 6 for each group; elastic modulus, one-way ANOVA; hardness, nonparametric test).<b> f</b>, Quantitative micro-CT analysis of tibial subchondral bone with trabecular bone volume per total volume (BV/TV; unpaired two-tailed Student’s <i>t</i>-test; n = 4 for each group) and trabecular bone pattern factor (Tb. Pf; unpaired two-tailed Student’s <i>t</i>-test; n = 4 for each group) in the vehicle and BNTA (1.5 mg kg<sup>-1</sup>) groups at 4 w and 8 w. Each data point represents one individual rat. All data are shown as the mean ± standard deviation (s. d.). *<i>P</i> &lt; 0.05, **<i>P</i> &lt; 0.01, ***<i>P</i> &lt; 0.001.
DOI: 10.6084/m9.figshare.7813940.v1
title: Table01_Ecuador_Volcanoes_Chiaradia.xlsx

description: Geochemical and radiogenic isotope data of volcanic edifices of Ecuador and southernmost Colombia
DOI: 10.6084/m9.figshare.7813901
title: Source Data Figure 3 .xlsx

description: <b>b, d, </b>the corresponding Osteoarthritis Research Society International (OARSI) scores from normal, sham, veh (vehicle)-treated, and BNTA-treated rats at 4 w and 8 w (n = 8 for each group; nonparametric test). <b>e, </b>Pain response times when rats were placed on the 55 °C hot plate meter at 4 w and 8 w post-surgery (n = 8 for each group, one-way ANOVA). <b>f, </b>The difference between the weight placed on the contralateral sham (left) hindlimb and the weight placed on the anterior cruciate ligament transection (ACLT, right) one at 4 w and 8 w post-surgery (n = 8 for each group, one-way ANOVA). Each data point represents one individual rat. All data are shown as the mean ± standard deviation (s. d.). *<i>P</i> &lt; 0.05, **<i>P</i> &lt; 0.01, ***<i>P</i> &lt; 0.001.
DOI: 10.6084/m9.figshare.7813907.v1
title: Source Data Figure 4 .xlsx

description: <b>a-b</b>, Quantification of mRNA levels for collagen type II alpha 1 chain (<i>Col2a1</i>), aggrecan<i> </i>(<i>Acan</i>), SRY-box 9 (<i>Sox9</i>), proteoglycan 4 (<i>Prg4</i>), C-C motif chemokine ligand 2 (<i>Ccl2</i>), interleukin (<i>Il</i>)<i>11</i>, <i>Il6</i>, ADAM metallopeptidase with thrombospondin type 1 motif (<i>Adamts</i>)<i>1</i>, <i>Adamts5</i>, matrix metalloproteinase (<i>Mmp</i>)<i>3,</i> and <i>Mmp13</i> in articular cartilage obtained from sham, vehicle, and BNTA-treated (1.5 mg kg<sup>-1</sup>) rats at 4 w and 8 w (a, <i>Col2a1</i>, <i>Acan,</i> <i>Sox9</i>, <i>Prg4, Adamts5</i>,<i> Ccl2</i>, <i>Il11</i>, <i>Il6</i>,<i> </i>and<i> Mmp3, </i>one-way ANOVA; <i>Adamts1</i> and <i>Mmp13, </i>nonparametric test; b, <i>Acan</i>, <i>Sox9</i>, <i>Prg4</i>, <i>Il11</i>, and <i>Mmp13, </i>one-way ANOVA; <i>Col2a1</i>, <i>Ccl2, Il6</i>, <i>Adamts1</i>, <i>Adamts5,</i> and <i>Mmp3, </i>nonparametric test; n = 5 for each group). <b>c</b>, Biomechanical properties of cartilage samples from sham, vehicle, and BNTA-treated (1.5 mg kg<sup>-1</sup>) rats at 4 w assessed using a nanoindentation test (n = 6 for each group; elastic modulus, one-way ANOVA; hardness, nonparametric test).<b> f</b>, Quantitative micro-CT analysis of tibial subchondral bone with trabecular bone volume per total volume (BV/TV; unpaired two-tailed Student’s <i>t</i>-test; n = 4 for each group) and trabecular bone pattern factor (Tb. Pf; unpaired two-tailed Student’s <i>t</i>-test; n = 4 for each group) in the vehicle and BNTA (1.5 mg kg<sup>-1</sup>) groups at 4 w and 8 w. Each data point represents one individual rat. All data are shown as the mean ± standard deviation (s. d.). *<i>P</i> &lt; 0.05, **<i>P</i> &lt; 0.01, ***<i>P</i> &lt; 0.001.
DOI: 10.6084/m9.figshare.7813877
title: Source Data Figure 2 .xlsx

description: <b>b</b>, The integrated optical density (IOD) value for proteoglycan content determined by safranin O-fast green staining (n = 8 for each group; one-way ANOVA).<b> c,</b> Proteoglycan staining area (%) determined by safranin O-fast green staining (n = 8 for each group; 2 w, one-way ANOVA; 3 w, nonparametric test).<b> e</b>, The mRNA levels of anabolic and inflammatory biomarkers in OA cartilage explants analyzed by reverse transcription polymerase chain reaction (RT-PCR) after BNTA treatment (0.1 μM) for 3 w (n = 5 for each group). proteoglycan 4 (<i>PRG4</i>), SRY-box 9 (<i>SOX9</i>), and interleukin 6 (<i>IL6</i>), unpaired two-tailed Student’s <i>t</i>-test; collagen type II alpha 1 chain (<i>COL2A1</i>), aggrecan<i> </i>(<i>ACAN</i>), heparan sulfate proteoglycan 2<i> </i>(<i>HSPG2</i>), and C-C motif chemokine ligand 2 (<i>CCL2</i>), nonparametric test. <b>f</b>, glycosaminoglycan (GAG) and DNA content per wet weight was assessed by 1, 9-dimethylmethylene blue (DMMB) and Hoechst 33258 assays after vehicle or BNTA treatment for 2 w, separately (n = 6 for each group; nonparametric test). Data are shown as the mean ± standard deviation (s. d.). *<i>P</i> &lt; 0.05, **<i>P</i> &lt; 0.01, ***<i>P</i> &lt; 0.001.
DOI: 10.6084/m9.figshare.7813886
title: Data and Rcode from the article "Global ecosystem thresholds driven by aridity", doi: 10.1126/science.aay5958

description: Data from " Berdugo, M., M. Delgado-Baquerizo, S. Soliveres, R. Hernández-Clemente, Y. Zhao, J. J. Gaitán, N. Gross, H. Saiz, V. Maire, A. Lehman, M. C. Rillig, R. V. Solé & F. T. Maestre. Global ecosystem thresholds driven by aridity. <i>Science </i>.... "<br>There is one folder with the database (6 files), and another with the bootstrapped parameters of the regressions presented in Fig. S2. Another file called "threshold final2" contains bootstrapped thresholds presented in Figure 1. Data regarding global maps and remote sensing can be downloaded freely from original sources. There are also two files with the necessary code to generate figures and perform analyses in R code. All the methodological details can be found in the article.<br>
DOI: 10.6084/m9.figshare.7813940.v2
title: Table01_Ecuador_Volcanoes_Chiaradia.xlsx

description: Geochemical and radiogenic isotope data of volcanic edifices of Ecuador and southernmost Colombia
DOI: 10.6084/m9.figshare.7813940.v3
title: Table01_Ecuador_Volcanoes_Chiaradia.xlsx

description: Geochemical and radiogenic isotope data of volcanic edifices of Ecuador and southernmost Colombia
DOI: 10.6084/m9.figshare.7813865
title: Source Data Suppletary Figure 5 .xlsx

description: The fluorescence intensity of superoxide dismutase 3 (SOD3) and type II collagen (COLII) in rat primary chondrocytes was quantified using LAS_X software when cultured with interleukin 1 beta ( IL1β, 10 ng ml<sup>-1</sup>), BNTA (0.1 μM), or siSOD3 for 2 d (n = 25 for each group; nonparametric tests). Data are shown as the mean ± standard deviation (s. d.). ***<i>P</i> &lt; 0.001.