cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.25442/hku.29850089
title: Supporting data for "Modelling Treatment (TRPV4 inhibitor) Response for Lamin A:C Related Dilated Cardiomyopathy in Human Induced Pluripotent Stem Cell Derived Cardiomyocytes and Transgenic Mice"

description: This project investigate the protective effect of TRPV4 inhibitor in LMNA p.R225X related DCM models. We evaluated the anti-apoptotic and anti-fibrotic effects of TRPV4 inhibitor in these models, examined cardiac function with TRPV4 inhibitor treatment, and validated the interactions between TRPV4 inhibitor and truncated lamin proteins. The in-vivo and in-vitro experiments were conducted with TRPV4 inhibitor treatment, including immunofluorescence of target proteins, western blotting, apoptosis analysis, and calcium measurement in LMNA p.R225X hiPSC-CMs, as well as protein analysis, cardiac function analysis in LMMA p.R225X mice. In vitro studies involved differentiating hiPSCs with the LMNA p.R225X variant into cardiomyocytes to evaluate how TRPV4 inhibitor influences apoptosis associated with LMNA-related DCM. Additionally, changes in lamin A/C were examined in lmnaWT/WT and lmnaR225X/WT hiPSC-CMs subjected to stresses. TRPV4 inhibitor treatment was found to reduce nuclear blebbing caused by chemical stress, as well as decrease apoptosis and the senescence-associated secretory phenotype at both protein and mRNA levels under mechanical stress. In vivo, the therapeutic potential of RN was assessed in transgenic mice carrying the LMNA p.R225X mutation. These mice received weekly intravenous injections of RN over four months, with cardiac function monitored monthly via echocardiography. The results demonstrated that RN improved systolic function and reduced cardiac fibrosis in lmnaR225X/WT mice.
DOI: 10.25442/hku.29850089.v1
title: Supporting data for "Modelling Treatment (TRPV4 inhibitor) Response for Lamin A:C Related Dilated Cardiomyopathy in Human Induced Pluripotent Stem Cell Derived Cardiomyocytes and Transgenic Mice"

description: This project investigate the protective effect of TRPV4 inhibitor in LMNA p.R225X related DCM models. We evaluated the anti-apoptotic and anti-fibrotic effects of TRPV4 inhibitor in these models, examined cardiac function with TRPV4 inhibitor treatment, and validated the interactions between TRPV4 inhibitor and truncated lamin proteins. The in-vivo and in-vitro experiments were conducted with TRPV4 inhibitor treatment, including immunofluorescence of target proteins, western blotting, apoptosis analysis, and calcium measurement in LMNA p.R225X hiPSC-CMs, as well as protein analysis, cardiac function analysis in LMMA p.R225X mice. In vitro studies involved differentiating hiPSCs with the LMNA p.R225X variant into cardiomyocytes to evaluate how TRPV4 inhibitor influences apoptosis associated with LMNA-related DCM. Additionally, changes in lamin A/C were examined in lmnaWT/WT and lmnaR225X/WT hiPSC-CMs subjected to stresses. TRPV4 inhibitor treatment was found to reduce nuclear blebbing caused by chemical stress, as well as decrease apoptosis and the senescence-associated secretory phenotype at both protein and mRNA levels under mechanical stress. In vivo, the therapeutic potential of RN was assessed in transgenic mice carrying the LMNA p.R225X mutation. These mice received weekly intravenous injections of RN over four months, with cardiac function monitored monthly via echocardiography. The results demonstrated that RN improved systolic function and reduced cardiac fibrosis in lmnaR225X/WT mice.
DOI: 10.25442/hku.29849018
title: Supporting data for "Hybrid extracellular vesicles derived from γδ-T and cancer cells enhance homologous tumor targeting and antitumor immunity"

description: Despite various cancer therapies aiming to precise tumor targeting and enhanced control efficacy, off-target effects and inadequate cytotoxicity continue to pose significant challenges. Thus, many research focus on the engineering of tumor cell-derived exosomes (T-EVs) because of their intrinsic "homing" capacity to target tumor sites. Our group's prior research has emphasized the remarkable anti tumor properties of exosomes produced from γδ-T cells (γδ-T-EVs). This study aims to improve the targeting efficiency of exosomes (EVs) by creating hybrid exosomes (H-EVs) through a freeze-thaw method that merges γδ-T-EVs with T-EVs. These H-EVs possess the characteristics of EVs from both parent cell types, allowing them to specifically recognize and effectively eradicate the parent tumor cells. Moreover, the maturation of dendritic cells (DCs) and activation of T cells were observed following stimulation with H-EVs, contributing to the reversal of their suppression in the tumor microenvironment. Proteomic analysis revealed that integrins facilitate the "homing" capability of H-EVs to tumor sites. These H-EVs efficiently targeted tumors, eliminated tumors, and extended survival in mice models, indicating a promising therapeutic strategy for cancer. Nonetheless, additional research is required to translate this H-EVs technology into clinical trials.
DOI: 10.25442/hku.29849018.v1
title: Supporting data for "Hybrid extracellular vesicles derived from γδ-T and cancer cells enhance homologous tumor targeting and antitumor immunity"

description: Despite various cancer therapies aiming to precise tumor targeting and enhanced control efficacy, off-target effects and inadequate cytotoxicity continue to pose significant challenges. Thus, many research focus on the engineering of tumor cell-derived exosomes (T-EVs) because of their intrinsic "homing" capacity to target tumor sites. Our group's prior research has emphasized the remarkable anti tumor properties of exosomes produced from γδ-T cells (γδ-T-EVs). This study aims to improve the targeting efficiency of exosomes (EVs) by creating hybrid exosomes (H-EVs) through a freeze-thaw method that merges γδ-T-EVs with T-EVs. These H-EVs possess the characteristics of EVs from both parent cell types, allowing them to specifically recognize and effectively eradicate the parent tumor cells. Moreover, the maturation of dendritic cells (DCs) and activation of T cells were observed following stimulation with H-EVs, contributing to the reversal of their suppression in the tumor microenvironment. Proteomic analysis revealed that integrins facilitate the "homing" capability of H-EVs to tumor sites. These H-EVs efficiently targeted tumors, eliminated tumors, and extended survival in mice models, indicating a promising therapeutic strategy for cancer. Nonetheless, additional research is required to translate this H-EVs technology into clinical trials.
DOI: 10.71782/data/zakbbd
title: Efficacy of gonioscopy-assisted transluminal trabeculotomy in advanced pseudoexfoliative glaucoma: A prospective study

description: The data files contain information on patients with pseudoexfoliative glaucoma who participated in a prospective study to compare the efficacy of gonioscopy-assited transluminal trabeculotomy (GATT) between groups with mild to moderate and advanced pseudoexfoliative glaucoma. All patients underwent GATT or GATT in combination with cataract surgery.The data contain information on patient demographics, treatment, and ophthalmological examination results prior to GATT and follow-up visits 12 months after surgery. Data on best corrected visual acuity, visual field, intraocular pressure, number of glaucoma medications, and complications are included for one visit before surgery and seven postoperative visits.
DOI: 10.15468/dl.afwkf7
title: Occurrence Download

description: A dataset containing 2116 species occurrences available in GBIF matching the query:
{
 "and" : [
 "OccurrenceStatus is Present",
 "TaxonKey is Graphocephala atropunctata"
 ]
}

 The dataset includes 2116 records from 15 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0041688-250811113504898/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.n8ebgq
title: Occurrence Download

description: A dataset containing 3 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Portulaca oleracea",
 "Country is Myanmar",
 "HasCoordinate is true"
 ]
}

 The dataset includes 3 records from 2 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0041689-250811113504898/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.96naqn
title: Occurrence Download

description: A dataset containing 236 species occurrences available in GBIF matching the query:
{
 "and" : [
 "OccurrenceStatus is Present",
 "TaxonKey is Graphocephala confluens"
 ]
}

 The dataset includes 236 records from 8 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0041690-250811113504898/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.82261/0s5r-9404
title: Epigraphische Datenbank zum antiken Kleinasien
title: EDAK
DOI: 10.15468/dl.myh8ur
title: Occurrence Download

description: A dataset containing 1904 species occurrences available in GBIF matching the query:
{
 "and" : [
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 "TaxonKey is Diabrotica virgifera"
 ]
}

 The dataset includes 1904 records from 39 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0041691-250811113504898/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.d9k8fm
title: Occurrence Download

description: A dataset containing 2 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Gobitrichinotus radiocularis)",
 "BasisOfRecord is one of (Specimen, Literature Occurrence, Human Observation, Observation)",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "Year is greater than or equal to 1991",
 "Year is less than or equal to 2025"
 ]
}

 The dataset includes 2 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0041692-250811113504898/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.9hxmax
title: Occurrence Download

description: A dataset containing 398857 species occurrences available in GBIF matching the query:
{
 "and" : [
 "DatasetKey is EOD – eBird Observation Dataset",
 "GadmGid is USA.47.106_1",
 "TaxonKey is Passeriformes",
 "Year 2002-2024"
 ]
}

 The dataset includes 398857 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0041658-250811113504898/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.5281/zenodo.16939741
title: Ground-Penetrating Radar Survey on Bisericuța Island (Adjacent to the Argamum Fortress) and Marine Magnetic Investigations at Grădiștea, Bisericuța Island, and the Argamum Fortress, Sptember 2022

description: Project: PN 19200501 INVESTIGAȚII GEOFIZICE DE MARE DETALIU PENTRU IDENTIFICAREA, PROTEJAREA ȘI VALORIFICAREA PATRIMONIULUI ARHEOLOGIC SUBMERS, AFLAT SUB IM-PACT ANTROPIC, ÎN ZONA CUPRINSĂ ÎNTRE CĂLĂRAȘI ȘI SULINA      Field campaign: SEPTEMBER 2022, faza 8-1

Acquisition instruments: Sensors and Software LMX200 GPR System with 250 MHz Antenna, Geometrics G882 Marine Magnetometer, Geometrics G856 Base Magnetometer/Gradientmeter, Trimble RTK R4 GNSS System   Locations: Jurilovca (Argamum, Bisericuta Island), Enisala (Geadistea), jud. Tulcea

Data operator/curator: Sorin Anghel, soanghel@geoecomar.ro

Coordinate System: Geographic - WGS 84/Stereo70 - Dealul Piscului 1970

Description: Synthesis of geophysical and geological data, as well as existing archaeological information, in the case of the Enisala and Argamum sites, located on the Danube bank downstream from Sulina

Software: Sensors and Software EKKO Project V5.0, Geosoft Oasis Montaj, Blue Marble Geographics Global Mapper, Microsoft Excel
DOI: 10.5281/zenodo.16939742
title: Ground-Penetrating Radar Survey on Bisericuța Island (Adjacent to the Argamum Fortress) and Marine Magnetic Investigations at Grădiștea, Bisericuța Island, and the Argamum Fortress, Sptember 2022

description: Project: PN 19200501 INVESTIGAȚII GEOFIZICE DE MARE DETALIU PENTRU IDENTIFICAREA, PROTEJAREA ȘI VALORIFICAREA PATRIMONIULUI ARHEOLOGIC SUBMERS, AFLAT SUB IM-PACT ANTROPIC, ÎN ZONA CUPRINSĂ ÎNTRE CĂLĂRAȘI ȘI SULINA      Field campaign: SEPTEMBER 2022, faza 8-1

Acquisition instruments: Sensors and Software LMX200 GPR System with 250 MHz Antenna, Geometrics G882 Marine Magnetometer, Geometrics G856 Base Magnetometer/Gradientmeter, Trimble RTK R4 GNSS System   Locations: Jurilovca (Argamum, Bisericuta Island), Enisala (Geadistea), jud. Tulcea

Data operator/curator: Sorin Anghel, soanghel@geoecomar.ro

Coordinate System: Geographic - WGS 84/Stereo70 - Dealul Piscului 1970

Description: Synthesis of geophysical and geological data, as well as existing archaeological information, in the case of the Enisala and Argamum sites, located on the Danube bank downstream from Sulina

Software: Sensors and Software EKKO Project V5.0, Geosoft Oasis Montaj, Blue Marble Geographics Global Mapper, Microsoft Excel
DOI: 10.15468/dl.eyed2u
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Portulaca oleracea",
 "Country is Tuvalu",
 "HasCoordinate is true"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0041695-250811113504898/datasets/export for details.
DOI: 10.15468/dl.yfuy63
title: Occurrence Download

description: A dataset containing 2451 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Portulaca oleracea",
 "Country is Russian Federation",
 "HasCoordinate is true"
 ]
}

 The dataset includes 2451 records from 23 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0041693-250811113504898/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.nffxrp
title: Occurrence Download

description: A dataset containing 44 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Portulaca oleracea",
 "Country is Uzbekistan",
 "HasCoordinate is true"
 ]
}

 The dataset includes 44 records from 5 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0041696-250811113504898/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.5281/zenodo.16938659
title: MG-PDB & MGBench: Benchmarking co-folding methods for molecular glue ternary structure prediction

description: Molecular glues (MGs) are a novel therapeutic modality that create or stabilize protein-protein interactions. To benchmark computational prediction of these systems, we present MG-PDB & MGBench, comprehensive datasets of MG ternary complex structures. This work evaluates several state-of-the-art co-folding methods: AlphaFold 3, Boltz-1, Chai-1, Protenix, and RoseTTAFold All-Atom.
DOI: 10.15468/dl.nyqcz2
title: Occurrence Download

description: A dataset containing 31 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Gobiesox cephalus)",
 "BasisOfRecord is one of (Specimen, Literature Occurrence, Human Observation, Observation)",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "Year is greater than or equal to 1991",
 "Year is less than or equal to 2025"
 ]
}

 The dataset includes 31 records from 6 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0041697-250811113504898/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.5281/zenodo.16939683
title: Electric Resistivity Measurements done in The Adjacent Area of Enisala Fortress, August 2022

description: Project: PN 19200501 INVESTIGAȚII GEOFIZICE DE MARE DETALIU PENTRU IDENTIFICAREA, PROTEJAREA ȘI VALORIFICAREA PATRIMONIULUI ARHEOLOGIC SUBMERS, AFLAT SUB IM-PACT ANTROPIC, ÎN ZONA CUPRINSĂ ÎNTRE CĂLĂRAȘI ȘI SULINA      Field campaign: AUGUST 2022, faza 8-1

Acquisition instruments: AGI Ministing, Trimble RTK R4 GNSS System   

Locations: Gradistea, Enisala, jud. Tulcea

Data operator/curator: Sorin Anghel, soanghel@geoecomar.ro

Coordinate System: Geographic - WGS 84/Stereo70 - Dealul Piscului 1970

Description: Synthesis of geophysical and geological data, as well as existing archaeological information, in the case of the Enisala and Argamum sites, located on the Danube bank downstream from Sulina

Software: AGI Earth Imger 2D/3D, Microsoft Excel
DOI: 10.5281/zenodo.16939684
title: Electric Resistivity Measurements done in The Adjacent Area of Enisala Fortress, August 2022

description: Project: PN 19200501 INVESTIGAȚII GEOFIZICE DE MARE DETALIU PENTRU IDENTIFICAREA, PROTEJAREA ȘI VALORIFICAREA PATRIMONIULUI ARHEOLOGIC SUBMERS, AFLAT SUB IM-PACT ANTROPIC, ÎN ZONA CUPRINSĂ ÎNTRE CĂLĂRAȘI ȘI SULINA      Field campaign: AUGUST 2022, faza 8-1

Acquisition instruments: AGI Ministing, Trimble RTK R4 GNSS System   

Locations: Gradistea, Enisala, jud. Tulcea

Data operator/curator: Sorin Anghel, soanghel@geoecomar.ro

Coordinate System: Geographic - WGS 84/Stereo70 - Dealul Piscului 1970

Description: Synthesis of geophysical and geological data, as well as existing archaeological information, in the case of the Enisala and Argamum sites, located on the Danube bank downstream from Sulina

Software: AGI Earth Imger 2D/3D, Microsoft Excel
DOI: 10.15468/dl.3msu78
title: Occurrence Download

description: A dataset containing 12233 species occurrences available in GBIF matching the query:
{
 "and" : [
 "HasCoordinate is true",
 "TaxonKey is Bignonia capreolata"
 ]
}

 The dataset includes 12233 records from 107 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0041694-250811113504898/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.6084/m9.figshare.29880239.v2
title: Chromosome-level genome assembly of Schizodactylus jimo using PacBio HiFi and Hi-C sequencingManage

description: The genome annotation file of <i>Schizodactylus jimo</i> contains a gff file, CDS and Pep files corresponding to its protein coding genes.The assembled genome of <i>Schizodactylus jimo.</i><br><br>
DOI: 10.15468/dl.4a3kvy
title: Occurrence Download

description: A dataset containing 542295 species occurrences available in GBIF matching the query:
{
 "and" : [
 "DatasetKey is EOD – eBird Observation Dataset",
 "GadmGid is IND.31.18_1",
 "TaxonKey is Passeriformes",
 "Year 2002-2024"
 ]
}

 The dataset includes 542295 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0041668-250811113504898/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.5281/zenodo.16363694
title: Cell location, marker intensities, positivities and phenotypes - Uppsala lung cancer cohort 2006-2010

description: Inform software extracted cell data, including nuclei features, marker intensity, marker positivity, and cell phenotypes. Cell data used in this dataset:https://github.com/MIDA-group/lung_cancer_BOMI2_dataset
DOI: 10.4121/82fa6380-c40c-4c40-b5ec-933b0253e6ce.v2
title: Data underlying the publication: Species sorting shapes the divergence of a natural bacterial community with repeatable functionality during propagation with alternative substrates

description: This data is derived from a field based adaptive evolution experiment. Here, we explored a process of species sorting and its consequence on community-level functionality using mabisi, a traditional Zambian fermented milk, by exposing a common mabisi microbial community to five distinct substrates and propagating replicate communities at three farm sites in rural Zambia. The substrates - raw bovine milk (control), low-fat milk, full-cream milk, and the infant formulas F100 and S26 – represented novel environments, were propagated at a fixed dilution and static conditions to generate ~ 66 generations. Microbial community composition was profiled through 16S rDNA sequencing, while community-level functioning was assessed through volatile organic compound profiling by GC-MS, pH changes with a pH meter, and consistency analysis using an Adam's consistometer.
DOI: 10.15468/dl.t5tw28
title: Occurrence Download

description: A dataset containing 23831 species occurrences available in GBIF matching the query:
{
 "and" : [
 "HasCoordinate is true",
 "TaxonKey is Allium roseum"
 ]
}

 The dataset includes 23831 records from 365 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0041698-250811113504898/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.6084/m9.figshare.29978254
title: First Time-Resolved Spectroscopic Observation of Upward Positive Leader Initiated from Tall Tower

description: Using a slitless spectrograph, we recorded for the first time the time-resolved spectra of an upward positive leader (UPL) from the 600-m Canton Tower, together with synchronized current and electric field measurements. Triggered by a positive cloud-to-ground flash, the UPL showed singly ionized nitrogen (NII) emissions confined to the rapidly advancing leader tip, while neutral atomic lines (e.g., Hα, OI) dominated the trailing channel below the tip. This has not been reported in spectral studies of downward leaders. Based on ionic emission presence, propagation of the upward positive leader could be divided into three stages: neutral-dominated heating stage, onset stage of NII at the tip, and decay stage of ionization. NII emissions were short-lived and confined to the tip, whereas neutral atom emissions persisted along the channel. These results reflect the microscopic physical processes of ionization, excitation, and channel cooling during UPL propagation.
DOI: 10.6084/m9.figshare.29978254.v1
title: First Time-Resolved Spectroscopic Observation of Upward Positive Leader Initiated from Tall Tower

description: Using a slitless spectrograph, we recorded for the first time the time-resolved spectra of an upward positive leader (UPL) from the 600-m Canton Tower, together with synchronized current and electric field measurements. Triggered by a positive cloud-to-ground flash, the UPL showed singly ionized nitrogen (NII) emissions confined to the rapidly advancing leader tip, while neutral atomic lines (e.g., Hα, OI) dominated the trailing channel below the tip. This has not been reported in spectral studies of downward leaders. Based on ionic emission presence, propagation of the upward positive leader could be divided into three stages: neutral-dominated heating stage, onset stage of NII at the tip, and decay stage of ionization. NII emissions were short-lived and confined to the tip, whereas neutral atom emissions persisted along the channel. These results reflect the microscopic physical processes of ionization, excitation, and channel cooling during UPL propagation.
DOI: 10.15468/dl.esnkek
title: Occurrence Download

description: A dataset containing 5 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Tamarix chinensis",
 "Country is Argentina",
 "HasCoordinate is true"
 ]
}

 The dataset includes 5 records from 2 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0041700-250811113504898/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.