cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.21942/uva.9272618
title: Conditional Clauses in Sign Language of the Netherlands

description: In deze map bevinden zich PDF-bestanden van de voorwaardelijke bijzinnen die ik heb onderzocht in de Nederlandse Gebarentaal. Dit zijn zinnen die ik uit het corpus NGT heb gehaald, en heb geanalyseerd op een aantal taalkundige aspecten: o.a. de aanwezigheid van manuele markering, non-manuele markering en de volgorde van hoofd- en bijzin. Verder staat er een read-me-bestand met verdere uitleg in deze map en een post-print manuscript van de bijbehorende studie.
DOI: 10.6084/m9.figshare.9272621
title: Effects of breed, management and personality on cortisol reactivity in sport horses

description: Sport horses need to fulfill high physical and psychological requirements during training and competition. These as well as certain conditions of modern husbandry may affect their wellbeing. Here we aimed to (1) evaluate effects of demographic and management factors as well as personality traits on stress reactivity of sport horses, (2) investigate if elite sport horses have elevated stress levels compared to amateur sport horses, and (3) assess whether different equestrian disciplines differentially influence horses' adrenal cortex responsiveness. For this purpose, we visited 149 healthy elite (<i>n</i>=94) and amateur (<i>n</i>=54) sport horses in Switzerland and performed an adrenocorticotropic hormone (ACTH) stimulation test. Additionally, a person who was familiar with the horse completed a questionnaire about demographic and management factors and horses’ personality traits. Linear models were calculated to assess associations between the questionnaire data and salivary cortisol 60 and 90 minutes after ACTH stimulation. While the model at T90 was not significant, post-stimulatory cortisol after 60 min appears most informative in line with a previous study and was significantly affected by the horses’ breed and by three management factors: “number of riders”, “hours spent outside” and “group housing” (adjusted r<sup>2 </sup>=15%, p&lt;0.001). Thoroughbred and Warmblood horses displayed an increased adrenal response compared to Franches-Montagnes horses. Horses with several riders had a less pronounced reaction than horses with one rider, and horses that spent more time outside had a decreased response compared to horses that were stabled most of the time. Horses living in groups showed higher post-stimulatory cortisol values than horses that were housed singly. However, no significant associations of cortisol responsiveness with personality traits were found, and neither the horses' use as elite or as amateur sport horses nor the discipline had an effect on the cortisol response. This suggests that optimizing husbandry conditions may be more important for improving horses' welfare than changing their use.
DOI: 10.6084/m9.figshare.9272579
title: Supplementary Material for: Differential Organ-Specific Tumor Response to Immune Checkpoint Inhibitors in Hepatocellular Carcinoma

description: <b><i>Background and Aims:</i></b> Immune checkpoint inhibitors (ICIs) exhibit significant clinical activity in patients with advanced hepatocellular carcinoma (HCC). This study explored whether tumor response to ICIs in HCC varies among different organs. <b><i>Methods:</i></b> We reviewed the data of patients with advanced HCC who had received ICIs. Patients with measurable diseases were enrolled. Organ-specific response criteria, adapted from RECIST 1.1 and immune-related RECIST, were used to evaluate the objective response to ICIs in tumors located in the liver, lung, lymph node, and other intra-abdominal sites. <b><i>Results:</i></b> Of the 75 enrolled patients with advanced HCC, 51 and 11 patients had chronic hepatitis B virus and chronic hepatitis C virus infection, respectively. Regarding ICI treatment, 58, 1, and 16 patients had undergone anti-PD-1/anti-PD-L1 monoclonal antibody (mAb) alone, anti-CTLA4 mAb alone, and anti-PD-1 mAb plus anti-CTLA4 mAb, respectively; 20 and 55 patients had received ICIs as first-line or ≥second-line therapy. The overall objective response rate (ORR) was 28.0%. In total, 58, 34, 19, and 18 patients had measurable hepatic tumors and lung, lymph node, and other intra-abdominal metastases, and the corresponding organ-specific ORRs were 22.4, 41.2, 26.3, and 38.9%, respectively. Of the 39 patients who had both hepatic and extrahepatic tumors, 12 had disease control in extrahepatic tumors while progressive disease (PD) in hepatic tumors, whereas only 4 exhibited disease control in hepatic tumors while PD in extrahepatic tumors (<i>p</i> = 0.046, McNemar test). Of the 16 patients with only evaluable tumors in the liver and lungs at baseline, 8 had disease control in the lungs while PD in the liver, and none experienced disease control in the liver while PD in the lungs (<i>p</i> = 0.005). <b><i>Conclusions:</i></b> The hepatic tumors of HCC may be less responsive to ICIs than extrahepatic lesions. Lung metastases responded most favorably to ICIs. The mechanisms underlying this differential response to ICIs warrant further investigation.
DOI: 10.6084/m9.figshare.9272621.v1
title: Effects of breed, management and personality on cortisol reactivity in sport horses

description: Sport horses need to fulfill high physical and psychological requirements during training and competition. These as well as certain conditions of modern husbandry may affect their wellbeing. Here we aimed to (1) evaluate effects of demographic and management factors as well as personality traits on stress reactivity of sport horses, (2) investigate if elite sport horses have elevated stress levels compared to amateur sport horses, and (3) assess whether different equestrian disciplines differentially influence horses' adrenal cortex responsiveness. For this purpose, we visited 149 healthy elite (<i>n</i>=94) and amateur (<i>n</i>=54) sport horses in Switzerland and performed an adrenocorticotropic hormone (ACTH) stimulation test. Additionally, a person who was familiar with the horse completed a questionnaire about demographic and management factors and horses’ personality traits. Linear models were calculated to assess associations between the questionnaire data and salivary cortisol 60 and 90 minutes after ACTH stimulation. While the model at T90 was not significant, post-stimulatory cortisol after 60 min appears most informative in line with a previous study and was significantly affected by the horses’ breed and by three management factors: “number of riders”, “hours spent outside” and “group housing” (adjusted r<sup>2 </sup>=15%, p&lt;0.001). Thoroughbred and Warmblood horses displayed an increased adrenal response compared to Franches-Montagnes horses. Horses with several riders had a less pronounced reaction than horses with one rider, and horses that spent more time outside had a decreased response compared to horses that were stabled most of the time. Horses living in groups showed higher post-stimulatory cortisol values than horses that were housed singly. However, no significant associations of cortisol responsiveness with personality traits were found, and neither the horses' use as elite or as amateur sport horses nor the discipline had an effect on the cortisol response. This suggests that optimizing husbandry conditions may be more important for improving horses' welfare than changing their use.
DOI: 10.6084/m9.figshare.9271583
title: Supplementary Material for: Noninvasive Prediction of Twitch Transdiaphragmatic Pressure: Insights from Spirometry, Diaphragm Ultrasound, and Phrenic Nerve Stimulation Studies

description: <b><i>Background:</i></b> Twitch transdiaphragmatic pressure (twPdi) following magnetic stimulation (MS) of the phrenic nerves is the gold standard for non-volitional assessment of diaphragm strength. Expiratory muscle function can be investigated using MS of the abdominal muscles and measurement of twitch gastric pressure (twPgas). <b><i>Objectives:</i></b> To investigate whether twitch pressures following MS of the phrenic and lower thoracic nerve roots can be predicted noninvasively by diaphragm ultrasound parameters and volitional tests of respiratory muscle strength. <b><i>Methods:</i></b> Sixty-three healthy subjects underwent standard spirometry, measurement of maximum inspiratory (PI<sub>max</sub>) and expiratory pressure (PE<sub>max</sub>), and diaphragm ultrasound. TwPdi following cervical MS of the phrenic nerve roots and twPgas after lower thoracic MS (twPgas-Thor) were measured using esophageal and gastric balloon catheters inserted transnasally. Using surface electrodes, compound muscle action potentials (CMAP) were simultaneously recorded from the diaphragm or obliquus abdominis muscles, respectively. <b><i>Results:</i></b> Forced expiratory flow (FEF<sub>25–75</sub>) was significantly correlated with twPdi (<i>r</i> = 0.37; <i>p</i> = 0.003) and its components (twPgas and twitch esophageal pressure, twPes). Diaphragm excursion velocity during tidal breathing was correlated to twPes (<i>r</i> = 0.44; <i>p</i> = 0.02). No prediction of twitch pressures was possible from CMAP amplitude, forced vital capacity (FVC), or PI<sub>max</sub>. TwPgas-Thor was correlated with FEF<sub>25–75</sub> (<i>r</i> = 0.46; <i>p</i> = 0.05) and diaphragm thickness at total lung capacity (<i>r</i> = 0.38; <i>p</i> = 0.04) but could not be predicted from CMAP amplitude, FVC, or PE<sub>max</sub>. <b><i>Conclusions:</i></b> TwPdi and twPgas-Thor cannot be predicted from volitional measures of respiratory muscle strength, diaphragm and abdominal CMAP, or diaphragm ultrasound. Invasive recording of esophageal and gastric pressures following MS remains indispensable for objective assessment of respiratory muscle strength.
DOI: 10.6084/m9.figshare.9267887
title: Supplementary Material for: Assessment of Losartan 50 mg on Survival of Post-Dialysis Euvolemic Hypertensive Patients: Findings from HELD Trial

description: <b><i>Aims and objective:</i></b> To estimate the effect of losartan 50 mg on survival of post-dialysis euvolemic hypertensive patients. <b><i>Methodology:</i></b> A single center, prospective, single-blind randomized trial was conducted to estimate the survival of post-dialysis euvolemic hypertensive patients when treated with lorsartan 50 mg every other day. Post-dialysis euvolemic assessment was done by a body composition monitor. Covariate Adaptive Randomization was used for allocation of participants to the standard or intervention arm, and the follow-up duration was twelve months. The primary end point was achieving targeted blood pressure (BP) of &lt;140/90 mm Hg and maintaining for 4 weeks, whereas secondary end point was all cause of mortality. Pre-, intra-, and post-dialysis session BP measurements were recorded, and survival trends were analyzed using Kaplan-Meier analysis. <b><i>Results:</i></b> Of the total 229 patients, 96 (41.9%) were identified as post-dialysis euvolemic hypertensive. Final samples of 88 (40.1%) patients were randomized into standard (<i>n</i> = 44) and intervention arms (<i>n</i> = 44), and 36 (81.8%) patients in each arm completed a follow-up of 12 months. A total of eight patients passed away during the 12-month follow-up period (6 deaths among standard arm and 2 in intervention arm). However, the probability of survival between both arms was not significant (<i>p</i> = 0.13). Cox regression analysis revealed that chances of survival were higher among the patients in the intervention (OR 3.17) arm than the standard arm (OR 0.31); however, the survival was found not statistically significant. <b><i>Conclusion:</i></b> There was no statistical significant difference in 1 year survival of post-dialysis euvolemic hypertensive patients when treated with losartan 50 mg.
DOI: 10.6084/m9.figshare.9271583.v1
title: Supplementary Material for: Noninvasive Prediction of Twitch Transdiaphragmatic Pressure: Insights from Spirometry, Diaphragm Ultrasound, and Phrenic Nerve Stimulation Studies

description: <b><i>Background:</i></b> Twitch transdiaphragmatic pressure (twPdi) following magnetic stimulation (MS) of the phrenic nerves is the gold standard for non-volitional assessment of diaphragm strength. Expiratory muscle function can be investigated using MS of the abdominal muscles and measurement of twitch gastric pressure (twPgas). <b><i>Objectives:</i></b> To investigate whether twitch pressures following MS of the phrenic and lower thoracic nerve roots can be predicted noninvasively by diaphragm ultrasound parameters and volitional tests of respiratory muscle strength. <b><i>Methods:</i></b> Sixty-three healthy subjects underwent standard spirometry, measurement of maximum inspiratory (PI<sub>max</sub>) and expiratory pressure (PE<sub>max</sub>), and diaphragm ultrasound. TwPdi following cervical MS of the phrenic nerve roots and twPgas after lower thoracic MS (twPgas-Thor) were measured using esophageal and gastric balloon catheters inserted transnasally. Using surface electrodes, compound muscle action potentials (CMAP) were simultaneously recorded from the diaphragm or obliquus abdominis muscles, respectively. <b><i>Results:</i></b> Forced expiratory flow (FEF<sub>25–75</sub>) was significantly correlated with twPdi (<i>r</i> = 0.37; <i>p</i> = 0.003) and its components (twPgas and twitch esophageal pressure, twPes). Diaphragm excursion velocity during tidal breathing was correlated to twPes (<i>r</i> = 0.44; <i>p</i> = 0.02). No prediction of twitch pressures was possible from CMAP amplitude, forced vital capacity (FVC), or PI<sub>max</sub>. TwPgas-Thor was correlated with FEF<sub>25–75</sub> (<i>r</i> = 0.46; <i>p</i> = 0.05) and diaphragm thickness at total lung capacity (<i>r</i> = 0.38; <i>p</i> = 0.04) but could not be predicted from CMAP amplitude, FVC, or PE<sub>max</sub>. <b><i>Conclusions:</i></b> TwPdi and twPgas-Thor cannot be predicted from volitional measures of respiratory muscle strength, diaphragm and abdominal CMAP, or diaphragm ultrasound. Invasive recording of esophageal and gastric pressures following MS remains indispensable for objective assessment of respiratory muscle strength.
DOI: 10.6084/m9.figshare.9266450
title: Supplementary Material for: Iron Regulation by Molidustat, a Daily Oral Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitor, in Patients with Chronic Kidney Disease

description: <b><i>Background/Aims:</i></b> The current treatment for anemia associated with chronic kidney disease (CKD) includes the administration of erythropoiesis stimulating agents (ESAs) combined with iron supplementation. Molidustat, a hypoxia-inducible factor prolyl hydroxylase inhibitor, has potential to treat anemia associated with CKD through increased erythropoietin production and improved iron availability. Here, we report the effect of molidustat on iron metabolism. <b><i>Method:</i></b> Parameters of iron metabolism were monitored in three 16-week, randomized, controlled, phase 2 studies assessing the safety and efficacy of molidustat in the treatment of anemia associated with CKD in different populations: treatment-naïve and previously ESA-treated patients not on dialysis, and previously ESA-treated patients on hemodialysis. Iron supplementation was left at the discretion of the investigator. <b><i>Results:</i></b> In treatment-naïve patients not on dialysis, transferrin saturation (TSAT), hepcidin, ferritin, and iron concentrations decreased with molidustat, whereas total iron binding capacity (TIBC) increased. Similar results were observed in previously ESA-treated patients not on dialysis, although changes in those parameters were larger in treatment-naïve than in previously ESA-treated patients. In previously ESA-treated patients receiving hemodialysis, hepcidin concentration and TIBC remained stable with molidustat, whereas TSAT and ferritin and iron concentrations increased. Generally, similar trends were observed in secondary analyses of subgroups of patients not receiving iron supplementation. <b><i>Conclusions:</i></b> Molidustat is a potential alternative to standard treatment of anemia associated with CKD, with a different mechanism of action. In patients not receiving dialysis, molidustat increases iron availability. In patients receiving hemodialysis, further investigation is required to understand fully the mechanisms underlying iron mobilization associated with molidustat.
DOI: 10.6084/m9.figshare.9266450.v1
title: Supplementary Material for: Iron Regulation by Molidustat, a Daily Oral Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitor, in Patients with Chronic Kidney Disease

description: <b><i>Background/Aims:</i></b> The current treatment for anemia associated with chronic kidney disease (CKD) includes the administration of erythropoiesis stimulating agents (ESAs) combined with iron supplementation. Molidustat, a hypoxia-inducible factor prolyl hydroxylase inhibitor, has potential to treat anemia associated with CKD through increased erythropoietin production and improved iron availability. Here, we report the effect of molidustat on iron metabolism. <b><i>Method:</i></b> Parameters of iron metabolism were monitored in three 16-week, randomized, controlled, phase 2 studies assessing the safety and efficacy of molidustat in the treatment of anemia associated with CKD in different populations: treatment-naïve and previously ESA-treated patients not on dialysis, and previously ESA-treated patients on hemodialysis. Iron supplementation was left at the discretion of the investigator. <b><i>Results:</i></b> In treatment-naïve patients not on dialysis, transferrin saturation (TSAT), hepcidin, ferritin, and iron concentrations decreased with molidustat, whereas total iron binding capacity (TIBC) increased. Similar results were observed in previously ESA-treated patients not on dialysis, although changes in those parameters were larger in treatment-naïve than in previously ESA-treated patients. In previously ESA-treated patients receiving hemodialysis, hepcidin concentration and TIBC remained stable with molidustat, whereas TSAT and ferritin and iron concentrations increased. Generally, similar trends were observed in secondary analyses of subgroups of patients not receiving iron supplementation. <b><i>Conclusions:</i></b> Molidustat is a potential alternative to standard treatment of anemia associated with CKD, with a different mechanism of action. In patients not receiving dialysis, molidustat increases iron availability. In patients receiving hemodialysis, further investigation is required to understand fully the mechanisms underlying iron mobilization associated with molidustat.
DOI: 10.6084/m9.figshare.9265121
title: Seker pancari mikrosatelit markorleri ve markor anotasyonlari

description: Seker pancari mikrosatelit markor ve anotasyon verisi
DOI: 10.6084/m9.figshare.9265121.v1
title: Seker pancari mikrosatelit markorleri ve markor anotasyonlari

description: Seker pancari mikrosatelit markor ve anotasyon verisi
DOI: 10.6084/m9.figshare.9264515
title: İncir SSR markörleri ve markör anotasyonları

description: İncir SSR markör ve anotasyon verisi<br>
DOI: 10.6084/m9.figshare.9264488
title: uparse_biom_file

description: biom file generated from UPARSE output.
DOI: 10.6084/m9.figshare.9264515.v1
title: İncir SSR markörleri ve markör anotasyonları

description: İncir SSR markör ve anotasyon verisi<br>
DOI: 10.6084/m9.figshare.9264476
title: uparse_otu_table

description: OTU table. Generated using UPARSE bioinformatic pipeline. Operational taxonomic units (OTUs) clustered at 97% similarity.
DOI: 10.17045/sthlmuni.9264449
title: Stabilization indices of housekeeping genes in roots of Datisca glomerata plantlets treated with different phytohormones

description: NormFinder (Andersen et al., 2004) stabilization indices of housekeeping genes used to calculate the normalizations factors in plantlet roots of Datisca glomerata. Indices were calculated in every assay to identify the most stable internal normalizer (or combination of normalizers) and are linked to the Figures of the manuscript.
DOI: 10.6084/m9.figshare.9264476.v1
title: uparse_otu_table

description: OTU table. Generated using UPARSE bioinformatic pipeline. Operational taxonomic units (OTUs) clustered at 97% similarity.
DOI: 10.17045/sthlmuni.9264449.v1
title: Stabilization indices of housekeeping genes in roots of Datisca glomerata plantlets treated with different phytohormones

description: NormFinder (Andersen et al., 2004) stabilization indices of housekeeping genes used to calculate the normalizations factors in plantlet roots of Datisca glomerata. Indices were calculated in every assay to identify the most stable internal normalizer (or combination of normalizers) and are linked to the Figures of the manuscript.
DOI: 10.6084/m9.figshare.9264332
title: tick-host-associations

description: Tick-host association data for chord plot analysis.
DOI: 10.6084/m9.figshare.9264332.v1
title: tick-host-associations

description: Tick-host association data for chord plot analysis.
DOI: 10.6084/m9.figshare.9259103
title: Table S8

description: Potential enzymes involved in lipid biosynthesis found encoded in Loki- and Thorarchaeota genomes. The protein identifiers of the enzymes from their respective genomes are listed. The Lokiarchaeota genomes are highlighted in green and Thorarchaea genomes are highlighted in blue.
DOI: 10.6084/m9.figshare.9259094
title: Table S6

description: Orthogroup (protein cluster) analysis based on all 13 genomes from Loki- and Thorarchaeota. Functional annotation for each of the orthogroups was predicted based on the majority rule of the proteins within each orthogroup.
DOI: 10.6084/m9.figshare.9259097
title: Table S7

description: BLASTp matches of the enzymes from Baja genomes against the protein sequences of the enzymes related to the degradation of aromatic amino acids. Query sequences were obtained from (Aklujkar et al., 2014).
DOI: 10.6084/m9.figshare.9259097.v1
title: Table S7

description: BLASTp matches of the enzymes from Baja genomes against the protein sequences of the enzymes related to the degradation of aromatic amino acids. Query sequences were obtained from (Aklujkar et al., 2014).
DOI: 10.6084/m9.figshare.9258968
title: Table S5

description: Loki- and Thorarchaeota protein orthogroups (clusters) affiliated with the arCOG categories “Mobilome” and “Defence mechanism”. Cluster annotation was based on the majority rule. Loki- and Thorarchaeota specific orthologous protein clusters are colored in green and blue respectively.
DOI: 10.6084/m9.figshare.9258968.v1
title: Table S5

description: Loki- and Thorarchaeota protein orthogroups (clusters) affiliated with the arCOG categories “Mobilome” and “Defence mechanism”. Cluster annotation was based on the majority rule. Loki- and Thorarchaeota specific orthologous protein clusters are colored in green and blue respectively.
DOI: 10.6084/m9.figshare.9258947
title: Table S4

description: Sheet 1: 16S rRNA gene sequences obtained from the SILVA database (version 132) whose taxonomic affiliations in the database do not match our phylogenetic analysis and their respective proposed corrections based on this study. Note: The “Unknown Asgard” sequences are the good quality shorter sequences that did not match to any of the reference sequences in the backbone tree with the given threshold (USEACH: 95% identity). Sheet 2: Accession numbers of all the sequences in the SILVA database that were removed from the analysis in this study due to low quality and chimeric.
DOI: 10.6084/m9.figshare.9258926
title: Table S3

description: List of all Loki- and Thorarchaeota genomes (13 in total) and their related information that has been used for the pan-genomic analyses.