cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.14597872
title: MIND diet and cognitive performance in older adults: a systematic review

description: Cognitive decline is a rapidly increasing public health concern. A healthy diet has potential in preserving brain and maintaining cognitive health. This systematic review was designed to evaluate the relationship between Mediterranean-DASH diet intervention for neurodegenerative delay (MIND) diet and cognitive functioning in older adults. PubMed, SCOPUS, Embase, Cochrane Library, and Google Scholar databases were searched to extract original studies on humans published until July 2020, without date restrictions. Articles that evaluated the association between MIND diet and cognitive performance in older adults were included. Duplicated and irrelevant studies were screened out and data were obtained through critical analysis. Quality of the articles and risk of bias was assessed by Newcastle-Ottawa and Cochrane Collaboration's quality assessment tools. Of the 135 studies retrieved, 13 articles (9 cohort, 3 cross-sectional, and 1 RCT studies) were included in the final review. All of the included studies indicated that adherence to the MIND diet was positively associated with specific domains, but not all, of cognition and global cognitive function (78% of the studies) in older adults. MIND diet was superior to other plant-rich diets including Mediterranean, Dietary Approaches to Stop Hypertension, Pro-Vegetarian and Baltic Sea diets, for improving cognition. Adherence to the MIND diet may possibly be associated with an improved cognitive function in older adults. MIND diet may be superior to other plant-rich diets for improving cognition.
DOI: 10.6084/m9.figshare.14597872.v1
title: MIND diet and cognitive performance in older adults: a systematic review

description: Cognitive decline is a rapidly increasing public health concern. A healthy diet has potential in preserving brain and maintaining cognitive health. This systematic review was designed to evaluate the relationship between Mediterranean-DASH diet intervention for neurodegenerative delay (MIND) diet and cognitive functioning in older adults. PubMed, SCOPUS, Embase, Cochrane Library, and Google Scholar databases were searched to extract original studies on humans published until July 2020, without date restrictions. Articles that evaluated the association between MIND diet and cognitive performance in older adults were included. Duplicated and irrelevant studies were screened out and data were obtained through critical analysis. Quality of the articles and risk of bias was assessed by Newcastle-Ottawa and Cochrane Collaboration's quality assessment tools. Of the 135 studies retrieved, 13 articles (9 cohort, 3 cross-sectional, and 1 RCT studies) were included in the final review. All of the included studies indicated that adherence to the MIND diet was positively associated with specific domains, but not all, of cognition and global cognitive function (78% of the studies) in older adults. MIND diet was superior to other plant-rich diets including Mediterranean, Dietary Approaches to Stop Hypertension, Pro-Vegetarian and Baltic Sea diets, for improving cognition. Adherence to the MIND diet may possibly be associated with an improved cognitive function in older adults. MIND diet may be superior to other plant-rich diets for improving cognition.
DOI: 10.6084/m9.figshare.16438477
title: An investigation of dynamic ulnar impingement after the Darrach procedure with ultrasonography

description: Dynamic ulnar impingement is a common and painful symptom after the Darrach procedure. However, the current detection method with <i>static</i> radiographs often falls short of examining the <i>dynamically</i> symptomatic wrists. We, therefore, investigate the utility of ultrasonography to assess dynamic ulnar impingement. In this cross-sectional study, 20 patients, with 22 wrists, who had undergone the Darrach procedure were evaluated at a mean of 55 months (range, 25–171) from the index procedure. Real-time ultrasonographic imaging in the axial plane of the bone and soft tissue was performed during three different dynamic testing methods, including weight-stressed (WS), pronation-supination (PS), and forceful fist clenching (FC), to investigate ulnar impingement. Dynamic radiographs were obtained for comparison. Clinical outcomes were evaluated with grip strength and patient-reported outcomes including pain in daily activities on a numeric rating scale (NRS), the Patient-Rated Wrist Evaluation (PRWE), and the Quick Disability of the Arm, Shoulder and Hand (QDASH). Ultrasonographic ulnar impingement found during PS method was associated with worse pain and function, yet impingement diagnosed with dynamic radiographs or ultrasonography with WS and FC method was not associated with worse outcomes. While radiographic impingement was found in a total of 12 wrists (55%), ultrasonography with the WS and PS method revealed true bone contact in only 2 (9%) and 4 (18%) of the wrists, respectively. The addition of ultrasonography may be valuable in follow-up evaluations after the Darrach procedure.
DOI: 10.6084/m9.figshare.16438477.v1
title: An investigation of dynamic ulnar impingement after the Darrach procedure with ultrasonography

description: Dynamic ulnar impingement is a common and painful symptom after the Darrach procedure. However, the current detection method with <i>static</i> radiographs often falls short of examining the <i>dynamically</i> symptomatic wrists. We, therefore, investigate the utility of ultrasonography to assess dynamic ulnar impingement. In this cross-sectional study, 20 patients, with 22 wrists, who had undergone the Darrach procedure were evaluated at a mean of 55 months (range, 25–171) from the index procedure. Real-time ultrasonographic imaging in the axial plane of the bone and soft tissue was performed during three different dynamic testing methods, including weight-stressed (WS), pronation-supination (PS), and forceful fist clenching (FC), to investigate ulnar impingement. Dynamic radiographs were obtained for comparison. Clinical outcomes were evaluated with grip strength and patient-reported outcomes including pain in daily activities on a numeric rating scale (NRS), the Patient-Rated Wrist Evaluation (PRWE), and the Quick Disability of the Arm, Shoulder and Hand (QDASH). Ultrasonographic ulnar impingement found during PS method was associated with worse pain and function, yet impingement diagnosed with dynamic radiographs or ultrasonography with WS and FC method was not associated with worse outcomes. While radiographic impingement was found in a total of 12 wrists (55%), ultrasonography with the WS and PS method revealed true bone contact in only 2 (9%) and 4 (18%) of the wrists, respectively. The addition of ultrasonography may be valuable in follow-up evaluations after the Darrach procedure.
DOI: 10.6084/m9.figshare.16663261
title: A meta-analysis of union rate after proximal scaphoid fractures: terminology matters

description: Heterogeneity in the anatomical definition of ‘proximal’ affects the comparison of outcomes of these scaphoid fractures. This study aims to review published outcomes of all variants to determine both, differences in terminology, and union rate based upon definition. A literature search was conducted to identify articles that reported descriptions and union rate of all acute (&lt;8 weeks of injury) proximal scaphoid fractures in adult patients (&gt;16 years old). Proximal fractures were grouped as reported (‘third’, ‘pole’, ‘fifth’ or ‘undefined’). The data were pooled using a fixed-effects method, and a meta-analysis was conducted to compare relative risk (RR) of non-union against non-proximal fractures. Qualitative analysis of 12 articles included three main definitions: ‘proximal’ (1 article), ‘proximal third’ (3 articles), and ‘proximal pole’ (8 articles). Only 6 articles adopted a specific anatomical or ratio description. In a pooled meta-analysis of union rates (15 articles), 'proximal third' and 'proximal pole' fractures demonstrated a relative risk (RR) of non-union of 2.3 and 3.4 in comparison to non-proximal fractures, respectively. Operative management yielded lower non-union rates than non-operative for all fracture types (6% vs. 18%). In conclusion, non-union risk varies depending on definition, with non-standardised classifications adding heterogeneity to reported outcomes. We recommend an approach utilizing fixed anatomical landmarks on plain radiographs (referencing scaphoid length and scapho-capitate joint) to standardise reporting of proximal fracture union in future studies. <b>Abbreviations</b>: CI: confidence intervals; CT: computer tomography; Df: degrees of freedom; DL: dersimonian and laird estimator; MRI: magnetic resonance imaging; NICE: national institute for health and care excellence; OTA: orthopaedic trauma association; PA: posterior-anterior; PRISMA: preferred reporting items for systematic reviews and meta analyses; RCT: randomised controlled trial; RR: relative risk; SNAC: scaphoid non-union advanced collapse; UK: United Kingdom
DOI: 10.6084/m9.figshare.16663261.v1
title: A meta-analysis of union rate after proximal scaphoid fractures: terminology matters

description: Heterogeneity in the anatomical definition of ‘proximal’ affects the comparison of outcomes of these scaphoid fractures. This study aims to review published outcomes of all variants to determine both, differences in terminology, and union rate based upon definition. A literature search was conducted to identify articles that reported descriptions and union rate of all acute (&lt;8 weeks of injury) proximal scaphoid fractures in adult patients (&gt;16 years old). Proximal fractures were grouped as reported (‘third’, ‘pole’, ‘fifth’ or ‘undefined’). The data were pooled using a fixed-effects method, and a meta-analysis was conducted to compare relative risk (RR) of non-union against non-proximal fractures. Qualitative analysis of 12 articles included three main definitions: ‘proximal’ (1 article), ‘proximal third’ (3 articles), and ‘proximal pole’ (8 articles). Only 6 articles adopted a specific anatomical or ratio description. In a pooled meta-analysis of union rates (15 articles), 'proximal third' and 'proximal pole' fractures demonstrated a relative risk (RR) of non-union of 2.3 and 3.4 in comparison to non-proximal fractures, respectively. Operative management yielded lower non-union rates than non-operative for all fracture types (6% vs. 18%). In conclusion, non-union risk varies depending on definition, with non-standardised classifications adding heterogeneity to reported outcomes. We recommend an approach utilizing fixed anatomical landmarks on plain radiographs (referencing scaphoid length and scapho-capitate joint) to standardise reporting of proximal fracture union in future studies. <b>Abbreviations</b>: CI: confidence intervals; CT: computer tomography; Df: degrees of freedom; DL: dersimonian and laird estimator; MRI: magnetic resonance imaging; NICE: national institute for health and care excellence; OTA: orthopaedic trauma association; PA: posterior-anterior; PRISMA: preferred reporting items for systematic reviews and meta analyses; RCT: randomised controlled trial; RR: relative risk; SNAC: scaphoid non-union advanced collapse; UK: United Kingdom
DOI: 10.6084/m9.figshare.20480811
title: Supplementary Material for: Sinomenine suppressed keratinocyte proliferation and imiquimod-induced psoriasis-like dermatitis by regulating lncRNA XIST

description: Background: Psoriasis is a chronic inflammatory skin disease. Sinomenine (SIN) has anti-inflammatory and antioxidant effects. Objective: To confirm the anti-inflammatory effects and mechanism of SIN in imiquimod (IMQ)-induced psoriasis-like mouse model and IMQ induced differentiated human keratinocytes (HaCaT) cells. Methods: BALB/c mice were treated with IMQ to construct a psoriasis-like mice model. PASI score and HE staining was used to observe pathology injury of skin tissue. The secretion of inflammatory factors and the oxidative stress level were detected by ELISA. The differentiated HaCaT cells were treated with IMQ (100 μM) and SIN (10 μg/mL or 50 μg/mL), cell viability, the secretion of inflammatory factors and the oxidative stress level were detected by MTT assay, ELISA, respectively. The expression of lncRNA XIST was detected by RT-qPCR. The relationship between XIST and EIF4G2 protein was detected by RNA Immunoprecipitation (RIP) assay, Ubiquitination experiment. Results: SIN significantly reduced PASI score, epidermal thickness, inflammatory response and oxidative stress levels that increased by IMQ in vivo. SIN inhibited IMQ-induced HaCaT cell proliferation, inflammatory response and oxidative stress levels, decreased the expression of XIST. Overexpression of XIST negated the protective effect of SIN on HaCaT cells. XIST interacted directly with EIF4G2 and regulate EIF4G2 expression via K48 ubiquitin. Knockdown of XIST reduced the half-life of EIF4G2 and decreased EIF4G2 protein stability. In addition, the E3 ubiquitin protein ligase MDM2 interacted with EIF4G2 and down-regulated EIF4G2 expression. XIST reduced the interaction between MDM2 and EIF4G2, which mediated EIF4G2 K48 ubiquitination. Overexpression of XIST negated the protective effect of SIN on the inflammation of HaCaT cells through activating the NF-κB signaling pathway, while NF-κB pathway inhibitor PDTC reversed this result. Conclusion: SIN had a protective effect on psoriasis and could inhibit HaCaT cell proliferation and inflammatory response via XIST/MDM2/EIF4G2/NF-κB axis.
DOI: 10.6084/m9.figshare.20480811.v1
title: Supplementary Material for: Sinomenine suppressed keratinocyte proliferation and imiquimod-induced psoriasis-like dermatitis by regulating lncRNA XIST

description: Background: Psoriasis is a chronic inflammatory skin disease. Sinomenine (SIN) has anti-inflammatory and antioxidant effects. Objective: To confirm the anti-inflammatory effects and mechanism of SIN in imiquimod (IMQ)-induced psoriasis-like mouse model and IMQ induced differentiated human keratinocytes (HaCaT) cells. Methods: BALB/c mice were treated with IMQ to construct a psoriasis-like mice model. PASI score and HE staining was used to observe pathology injury of skin tissue. The secretion of inflammatory factors and the oxidative stress level were detected by ELISA. The differentiated HaCaT cells were treated with IMQ (100 μM) and SIN (10 μg/mL or 50 μg/mL), cell viability, the secretion of inflammatory factors and the oxidative stress level were detected by MTT assay, ELISA, respectively. The expression of lncRNA XIST was detected by RT-qPCR. The relationship between XIST and EIF4G2 protein was detected by RNA Immunoprecipitation (RIP) assay, Ubiquitination experiment. Results: SIN significantly reduced PASI score, epidermal thickness, inflammatory response and oxidative stress levels that increased by IMQ in vivo. SIN inhibited IMQ-induced HaCaT cell proliferation, inflammatory response and oxidative stress levels, decreased the expression of XIST. Overexpression of XIST negated the protective effect of SIN on HaCaT cells. XIST interacted directly with EIF4G2 and regulate EIF4G2 expression via K48 ubiquitin. Knockdown of XIST reduced the half-life of EIF4G2 and decreased EIF4G2 protein stability. In addition, the E3 ubiquitin protein ligase MDM2 interacted with EIF4G2 and down-regulated EIF4G2 expression. XIST reduced the interaction between MDM2 and EIF4G2, which mediated EIF4G2 K48 ubiquitination. Overexpression of XIST negated the protective effect of SIN on the inflammation of HaCaT cells through activating the NF-κB signaling pathway, while NF-κB pathway inhibitor PDTC reversed this result. Conclusion: SIN had a protective effect on psoriasis and could inhibit HaCaT cell proliferation and inflammatory response via XIST/MDM2/EIF4G2/NF-κB axis.
DOI: 10.5255/ukda-sn-856002
title: Qualitative Election Study of Britain Party Leader Evaluations Database, 2010-2019

description: The Qualitative Election Study of Britain (QESB) Party Leader Evaluation Database 2010 – 2019 contains 4,119 words and phrases that evaluate British political party leaders. The data were collected during pre-election focus groups and interviews conducted with participants from England, Scotland and Wales, during the General Election campaigns of 2010, 2015, 2017, and 2019. For the party leader evaluation pre-election component, participants were provided with head shot pictures of the party leaders (depending on where in Britain they lived) taken from the party’s own website. They were instructed to write down words or phrases they associate with each person, and indicate if that association was positive, negative or neutral. The data structure mirrors data structures used in sentiment analysis. Each tab contains a column listing participant’s’ words and phrases as a string variable; the next two columns list the election year and leader, affective evaluations (relating to, arising from, or influencing feelings or emotions) as a string variable, and the affective evaluation as a numeric scale from negative –1 to positive +1. These data are suitable for sentiment and discourse analysis, or analytic generalization – establishing that a concept exists within a population regardless of the number of people who hold it. In addition, a supplementary dataset is provided of leaders’ evaluation data from a study with residents of Dundee after the Scottish Independence Referendum in 2014 (N = 287).
DOI: 10.5281/zenodo.7155729
title: GLORIA 3-D temperature and ALIMA temperature measurements from flight 12 of the SouthTRAC measurement campaign

description: This dataset consists of temperature measurements acquired from the German HALO research aircraft during a research flight over Southern Andes on 20-21 September, 2019, as part of the SouthTRAC measurement campaign. ALIMA lidar instrument is developed and operated by the German Aerospace center (Deutsches Zentrum für Luft- und Raumfahrt, DLR). The data included here covers the whole research flight. GLORIA infrared limb imaging spectrometer is jointly developed and operated by the Jülich Research Center (Forschungszentrum Jülich). The data included here is the 3-D temperature retrieval from the hexagonal flight pattern, which was flown from 02:50 UTC till 06:10 UTC on 21 Septermber, 2019.
DOI: 10.5281/zenodo.7155728
title: GLORIA 3-D temperature and ALIMA temperature measurements from flight 12 of the SouthTRAC measurement campaign

description: This dataset consists of temperature measurements acquired from the German HALO research aircraft during a research flight over Southern Andes on 20-21 September, 2019, as part of the SouthTRAC measurement campaign. ALIMA lidar instrument is developed and operated by the German Aerospace center (Deutsches Zentrum für Luft- und Raumfahrt, DLR). The data included here covers the whole research flight. GLORIA infrared limb imaging spectrometer is jointly developed and operated by the Jülich Research Center (Forschungszentrum Jülich). The data included here is the 3-D temperature retrieval from the hexagonal flight pattern, which was flown from 02:50 UTC till 06:10 UTC on 21 Septermber, 2019.
DOI: 10.5281/zenodo.7154396
title: TFGen HIDS

description: Code, Dataset, Document and results
DOI: 10.5281/zenodo.7154395
title: TFGen HIDS

description: Code, Dataset, Document and results
DOI: 10.6084/m9.figshare.21293712
title: Appendices

description: The supplemental materials, methods and data
DOI: 10.6084/m9.figshare.21293712.v1
title: Appendices

description: The supplemental materials, methods and data
DOI: 10.34730/ae6cc8cfd8b2411386becd5259d641e0
title: DeepRain project presentations

description: In this entry a collection of internal publications, presentations, slides and reports from DeepRain. DeepRain is funded by the Bundesministerium für Bildung und Forschung (BMBF) under grant agreement 01 IS18047A-E.
DOI: 10.6084/m9.figshare.20335143.v4
title: Appendices.docx

description: The supplemental materials, methods and data
DOI: 10.34740/kaggle/dsv/4147023
title: Metal Surface Defects Dataset
DOI: 10.6084/m9.figshare.20732023.v1
title: Supplementary Material for: Intranasal Insulin Attenuates the Long-term Adverse Effects of Neonatal Hyperglycemia on the Hippocampus in Rats

description: Hyperglycemia due to relative hypoinsulinism is common in extremely preterm infants and is associated with hippocampus-mediated long-term cognitive impairment. In neonatal rats, hypoinsulinemic hyperglycemia leads to oxidative stress, altered neurochemistry, microgliosis and abnormal synaptogenesis in the hippocampus. Intranasal insulin (INS) bypasses the blood-brain barrier, targets the brain and improves synaptogenesis in rodent models, and memory in adult humans with Alzheimer’s Disease or type 2 diabetes, without altering the blood levels of insulin or glucose. To test whether INS improves hippocampal development in neonatal hyperglycemia, rat pups were subjected to hypoinsulinemic hyperglycemia by injecting streptozotocin (STZ) at a dose of 80 mg/kg i.p. on postnatal day (P) 2 and randomized to INS, 0.3U twice daily from P3-P6 (STZ + INS group) or no treatment (STZ group). The acute effects on hippocampal neurochemical profile and transcript mRNA expression of insulin receptor (Insr), glucose transporters (Glut1, Glut 4 and Glut8) and poly(ADP-ribose)polymerase-1(Parp1, a marker of oxidative stress) were determined on P7 using in vivo 1H MR spectroscopy (MRS) and qPCR. The long-term effects on the neurochemical profile, microgliosis and synaptogenesis were determined at adulthood using 1H MRS and histochemical analysis. Relative to the control (CONT) group, mean blood glucose concentration was higher from P3 to P6 in the STZ and STZ+INS groups. On P7, MRS showed 10% higher taurine concentration in both STZ groups. qPCR showed 3-folds higher Insr and 5-folds higher Glut8 expression in the two STZ groups. Parp1 expression was 18% higher in the STZ group and normal in the STZ + INS group. At adulthood, blood glucose concentration in the fed state was higher in the STZ and STZ + INS groups. MRS showed 59% higher brain glucose concentration and histochemistry showed microgliosis in the hippocampal subareas in the STZ group. Brain glucose was normal in the STZ + INS group. Compared with the STZ group, phosphocreatine and phosphocreatine/creatine ratio were higher, and microglia in the hippocampal subareas fewer in the STZ + INS group (p &lt; 0.05 for all). Neonatal hyperglycemia was associated with abnormal glucose metabolism and microgliosis in the adult hippocampus. INS administration during hyperglycemia attenuated these adverse effects and improved energy metabolism in the hippocampus.