cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.14457/cu.the.2012.835
title: The study of the altering of cytokines and growth factors secreted by cultured balding dermal papilla cells

description: BACKGROUND: Recent studies established that androgen-driven alteration to signals produced by dermal papilla (DP) cells may play an important role in androgenetic alopecia. Here we screened the difference in the protein expression of growth factors/ cytokines in balding vs nonbalding DP cells from the same individuals affected with AGA and found neurotrophins (NTs), namely brain-derived nerve factor (BDNF), neurotrophin (NT)-3 and beta-nerve growth factor (NGF), were the most upregulated protein.OBJECTIVES: To further investigate the effects of four recombinant human (rh) NTs: BDNF, NGF, NT-3 and NT-4 on the proliferation of cultured balding DP cells and hair follicle (HF) growth in vitro. We also assessed whether the neutralizing NTs antibody can reverse the negative effects of NTs.MATERIALS AND METHODS: We evaluated the effects the effects of various concentrations of rhNTs on the proliferation of cultured balding DP cells by MTT assay at day 2 and 4. We also measured elongation of anagen hair follicles in organ culture. Furthermore, the reversible effects of NTs were investigated when the neutralizing NTs antibody was added.RESULTS: NGF, NT-3 and NT-4 at concentration of 10ng/mL and NT-4 at 0.1ng/ mL significantly inhibited proliferation of DP cells at day 2. The more inhibitory effects were observed on day 4, NGF and NT-4 at concentration of 0.1, 1 and 10 ng/ mL showed significantly inhibit DP cells proliferation in dose dependent manner. Moreover, after 10-day of HF organ culture, 1ng/ mL BDNF and NGF significantly inhibited hair shaft growth by 610.2 µm,-44.3% (P=0.003) and 395.7µm, -28.7% (P=0.05), respectively compared with control. Lastly, all NTs neutralizing antibodies failed to reverse NTs-induced cultured DP cells and hair follicles growth inhibition. However, we could observe reversible trend from our results.CONCLUSIONS: NTs produced by balding DP cells inhibit the proliferation of DP cells and human hair follicle growth in vitro. This data, together with the higher expression of NTs in balding compared with nonbalding DP cells suggests that NTs may be one of the key factors involved in pathogenesis of AGA.
DOI: 10.25919/5d80609933de7
title: Parkes observations for project P958 semester 2019APRS_87

description: Fast radio bursts (FRBs) continue to raise more questions than they answer. Until a few months ago, only one burst – the only one known to repeat - had been localized to a bright radio nebula (either a young supernova remnant or pulsar wind nebulae) in a distant dwarf galaxy. Over the last year searches with the Australian Square Kilometre Array Pathfinder (ASKAP) have detected 28 bursts, two of which have been localised to host galaxies at redshifts &gt; 0.3. These bursts and their hosts are very unlike the repeater, suggesting there may be a dichotomy in the population. Over the next six months we expect to detect another 12 FRBs, which will also have sub-arcsecond localisations. Here we propose to search this population for repeats. Our comprehensive sample and a dense monitoring campaign of well localised bursts, at a fluence limit more than 60 times lower than that of their detections, will either confirm the presence of additional repeating FRBs or the uniqueness of FRB 121102 amongst the population.
DOI: 10.21227/tf9m-ym13
title: Damage Detection and Characterisation in Composites using a Geometric Modification of the RAPID Algorithm

description: The dataset contains some tests which were performed over composite material samples, propagating Lamb waves using PZT transducers.
DOI: 10.5281/zenodo.3406568
title: Dataset related to article "Liver metastases from colorectal cancer: propensity score-based comparison of stereotactic body radiation therapy vs. microwave ablation"

description: This record contains raw data related to article "Liver metastases from colorectal cancer: propensity score-based comparison of stereotactic body radiation therapy vs. microwave ablation" PURPOSE: The study aim was to compare the disease control in two groups of patients affected by liver metastases from CRC treated with microwave ablation (MWA) or stereotactic body radiation therapy (SBRT). METHODS: We extracted data of patients treated between 2009 and 2016. Inclusion criteria were: (1) maximum diameter of the liver lesions less than 4 cm; (2) no more than three liver lesions; (3) no evidence of progressive or untreated gross disease outside the liver; (4) adequate liver function; (5) no concurrent chemotherapy; (6) minimum age of 18. Tumour response was classified according to EORTC-RECIST criteria. Aim of the present study was to evaluate freedom from local progression (FFLP). To reduce indication bias, an inverse probability of treatment weighting was used to estimate treatment effect. RESULTS: A total of 135 patients with 214 lesions were included in the analysis. Median follow-up time was 24.5 months (range 2.4-95.8). The 1-year freedom from local progression (FFLP) was 88% (95%CI 80-92). In the SBRT group, FFLP was statistically longer than MWA group (p = 0.0214); the 1-year FFLP was 91% (95% CI 81-95) in SBRT group and 84% (95% CI 0.72-0.91) in MWA group. Patients treated with SBRT showed a reduce risk of local relapse compared to MWA (adjusted HR 0.31; 95%CI 0.13-0.70, p = 0.005). As expected, analogous result obtained in the inverse probability weighting analysis (HR 0.38; 95%CI 0.18-0.80; p = 0.011). CONCLUSION: In conclusion, there seems to be an advantage of SBRT compared to MWA in treating CRC liver metastases, particularly for lesions bigger than 30 mm.
DOI: 10.5281/zenodo.3406569
title: Dataset related to article "Liver metastases from colorectal cancer: propensity score-based comparison of stereotactic body radiation therapy vs. microwave ablation"

description: This record contains raw data related to article "Liver metastases from colorectal cancer: propensity score-based comparison of stereotactic body radiation therapy vs. microwave ablation" PURPOSE: The study aim was to compare the disease control in two groups of patients affected by liver metastases from CRC treated with microwave ablation (MWA) or stereotactic body radiation therapy (SBRT). METHODS: We extracted data of patients treated between 2009 and 2016. Inclusion criteria were: (1) maximum diameter of the liver lesions less than 4 cm; (2) no more than three liver lesions; (3) no evidence of progressive or untreated gross disease outside the liver; (4) adequate liver function; (5) no concurrent chemotherapy; (6) minimum age of 18. Tumour response was classified according to EORTC-RECIST criteria. Aim of the present study was to evaluate freedom from local progression (FFLP). To reduce indication bias, an inverse probability of treatment weighting was used to estimate treatment effect. RESULTS: A total of 135 patients with 214 lesions were included in the analysis. Median follow-up time was 24.5 months (range 2.4-95.8). The 1-year freedom from local progression (FFLP) was 88% (95%CI 80-92). In the SBRT group, FFLP was statistically longer than MWA group (p = 0.0214); the 1-year FFLP was 91% (95% CI 81-95) in SBRT group and 84% (95% CI 0.72-0.91) in MWA group. Patients treated with SBRT showed a reduce risk of local relapse compared to MWA (adjusted HR 0.31; 95%CI 0.13-0.70, p = 0.005). As expected, analogous result obtained in the inverse probability weighting analysis (HR 0.38; 95%CI 0.18-0.80; p = 0.011). CONCLUSION: In conclusion, there seems to be an advantage of SBRT compared to MWA in treating CRC liver metastases, particularly for lesions bigger than 30 mm.
DOI: 10.7910/dvn/zvnazw/fkwgne
title: nlsy_replication_code.do
DOI: 10.7910/dvn/zvnazw/i8ntqs
title: psp_replication_code.do
DOI: 10.7910/dvn/zvnazw/dpkj8g
title: nlsy_replication_file.tab
DOI: 10.7910/dvn/zvnazw/fpk9ti
title: psp_replication_file.tab
DOI: 10.7910/dvn/zvnazw/lnlehi
title: psp_parent_regressions.tab
DOI: 10.7910/dvn/zvnazw/z5lp4b
title: merge_chore_into_rest.tab
DOI: 10.5281/zenodo.3406374
title: Dataset related to article "Critical appraisal of the potential role of intensity modulated proton therapy in the hypofractionated treatment of advanced hepatocellular carcinoma"

description: This record contains raw data related to article "Critical appraisal of the potential role of intensity modulated proton therapy in the hypofractionated treatment of advanced hepatocellular carcinoma" PURPOSE: To investigate the role of intensity modulated proton therapy (IMPT) for advanced hepatocellular carcinoma in comparison with volumetric modulated arc therapy (VMAT). METHODS: An in-silico planning study was performed on 20 patients. The prescription dose was 60Gy in 6 fractions. Patients were planned with abdominal compression. IMPT plans were optimized with or without the inclusion of CT calibration (3%) and isocenter positioning (2,4,6mm) uncertainties. Plan robustness was appraised comparing rubust optimized plans vs standard plans and also in terms of the worst-case scenario. VMAT plans were optimized for 10FFF photon beams using 2 partial arcs. RESULTS: Target coverage was fully achieved by both VMAT and IMPT plans with a significant improvement in homogeneity (~25%) with IMPT. Integral dose was reduced of ~60% with IMPT while the conformality of the dose distributions was similar among techniques. The sparing of the organs at risk was strongly improved with IMPT although all clinical objectives were met for both techniques. The inclusion of the uncertainties in the optimization lead to some deterioration in the target dose homogeneity (from 40 to 80% worse with 4 or 6mm position uncertainty) while none of the coverage parameters or OAR objective was violated. The worst-case scenario analysis demonstrated the risk of a major target underdosage only in the case of the most extreme errors (6mm) with D98% in average ~12% lower than the threshold. CONCLUSION: IMPT with the support of abdominal compression, can be considered a viable solution also for advanced hepatocellular carcinoma patients. Great care shall be put in the minimization of the residual respiration and positioning uncertainties but the dosimetric advantage for organs at risk and the relative robustness on target coverage are promising factors.
DOI: 10.5281/zenodo.3406375
title: Dataset related to article "Critical appraisal of the potential role of intensity modulated proton therapy in the hypofractionated treatment of advanced hepatocellular carcinoma"

description: This record contains raw data related to article "Critical appraisal of the potential role of intensity modulated proton therapy in the hypofractionated treatment of advanced hepatocellular carcinoma" PURPOSE: To investigate the role of intensity modulated proton therapy (IMPT) for advanced hepatocellular carcinoma in comparison with volumetric modulated arc therapy (VMAT). METHODS: An in-silico planning study was performed on 20 patients. The prescription dose was 60Gy in 6 fractions. Patients were planned with abdominal compression. IMPT plans were optimized with or without the inclusion of CT calibration (3%) and isocenter positioning (2,4,6mm) uncertainties. Plan robustness was appraised comparing rubust optimized plans vs standard plans and also in terms of the worst-case scenario. VMAT plans were optimized for 10FFF photon beams using 2 partial arcs. RESULTS: Target coverage was fully achieved by both VMAT and IMPT plans with a significant improvement in homogeneity (~25%) with IMPT. Integral dose was reduced of ~60% with IMPT while the conformality of the dose distributions was similar among techniques. The sparing of the organs at risk was strongly improved with IMPT although all clinical objectives were met for both techniques. The inclusion of the uncertainties in the optimization lead to some deterioration in the target dose homogeneity (from 40 to 80% worse with 4 or 6mm position uncertainty) while none of the coverage parameters or OAR objective was violated. The worst-case scenario analysis demonstrated the risk of a major target underdosage only in the case of the most extreme errors (6mm) with D98% in average ~12% lower than the threshold. CONCLUSION: IMPT with the support of abdominal compression, can be considered a viable solution also for advanced hepatocellular carcinoma patients. Great care shall be put in the minimization of the residual respiration and positioning uncertainties but the dosimetric advantage for organs at risk and the relative robustness on target coverage are promising factors.
DOI: 10.5281/zenodo.3406411
title: Dataset related to article "Role of 11 C-choline PET/CT in radiation therapy planning of patients with prostate cancer"

description: This record contains raw data related to article "Role of 11 C-choline PET/CT in radiation therapy planning of patients with prostate cancer" BACKGROUND: In the era of image-guided radiotherapy, PET has become an important tool for tumor delineation in several types of cancer. The aim of this study was to evaluate the effect of this imaging modality in treatment planning of a cohort of patients with prostate cancer eligible for radiotherapy. METHODS: From September 2011 to January 2016, 135 consecutive patients (median age 69 years, range: 53-89) were referred to our department for radiation therapy with radical intent (n=28), for postoperative adjuvant (n=13) or salvage treatment (n=50), for re-irradiation (n=19), or for radiotherapy on oligometastases (n=25). Before planning the radiotherapy course, patients were submitted to carbon-11-choline PET (Cho-PET) to confirm the indication to radiotherapy and the irradiation volumes. RESULTS: Among the 135 patients subjected to Cho-PET, the indication to radiotherapy was modified in 66 (48.8%) cases based on the Cho-PET result. In particular, Cho-PET helped to better define the radiotherapy programme in 12 out of 28 (42.8%) patients who were candidates for primary radiation therapy, 33 (52.4%) of 63 patients undergoing adjuvant/salvage radiotherapy, and 21 out of 44 (47.7%) patients with relapsed/metastatic disease. Overall biochemical response is documented by mean and median prostate specific antigen values, which changed from 15.29 to 4.00 ng/ml, respectively, before to mean 4.74 ng/ml and median 0.81 ng/ml after therapy (P=0.05). CONCLUSION: In our series, Cho-PET had a significant effect on radiotherapy planning of patients affected by prostate cancer, determining a change in management in 48.8% of cases, considering all therapeutic indications
DOI: 10.5281/zenodo.3406412
title: Dataset related to article "Role of 11 C-choline PET/CT in radiation therapy planning of patients with prostate cancer"

description: This record contains raw data related to article "Role of 11 C-choline PET/CT in radiation therapy planning of patients with prostate cancer" BACKGROUND: In the era of image-guided radiotherapy, PET has become an important tool for tumor delineation in several types of cancer. The aim of this study was to evaluate the effect of this imaging modality in treatment planning of a cohort of patients with prostate cancer eligible for radiotherapy. METHODS: From September 2011 to January 2016, 135 consecutive patients (median age 69 years, range: 53-89) were referred to our department for radiation therapy with radical intent (n=28), for postoperative adjuvant (n=13) or salvage treatment (n=50), for re-irradiation (n=19), or for radiotherapy on oligometastases (n=25). Before planning the radiotherapy course, patients were submitted to carbon-11-choline PET (Cho-PET) to confirm the indication to radiotherapy and the irradiation volumes. RESULTS: Among the 135 patients subjected to Cho-PET, the indication to radiotherapy was modified in 66 (48.8%) cases based on the Cho-PET result. In particular, Cho-PET helped to better define the radiotherapy programme in 12 out of 28 (42.8%) patients who were candidates for primary radiation therapy, 33 (52.4%) of 63 patients undergoing adjuvant/salvage radiotherapy, and 21 out of 44 (47.7%) patients with relapsed/metastatic disease. Overall biochemical response is documented by mean and median prostate specific antigen values, which changed from 15.29 to 4.00 ng/ml, respectively, before to mean 4.74 ng/ml and median 0.81 ng/ml after therapy (P=0.05). CONCLUSION: In our series, Cho-PET had a significant effect on radiotherapy planning of patients affected by prostate cancer, determining a change in management in 48.8% of cases, considering all therapeutic indications
DOI: 10.15468/zouvxb
title: A new species of Adamystis (Acari: Trombidiformes: Adamystidae) from Iran

description: This dataset contains the digitized treatments in Plazi based on the original journal article Ghasemi-Moghadam, Sahebeh, Ahadiyat, Ali, Saboori, Alireza, Fathipour, Yaghoub (2019): A new species of Adamystis (Acari: Trombidiformes: Adamystidae) from Iran. Zootaxa 4647 (1): 14-22, DOI: https://doi.org/10.11646/zootaxa.4647.1.4
DOI: 10.14284/373
title: Distribution of benthic macroinvertebrate living modes in European seas

description: This series of products displays the main functional types of benthic macroinvertebrates derived from a multivariate analysis of 13 life history traits. Several occurrence lists from EMODnet Biology were combined. A multivariate analysis of the life history traits revealed three main living modes. All final outcomes were interpolated by DIVAnd, the n-dimensional Data Interpolating Variational Analysis tool.
description: The first living mode one comprises species resistant to physical stress in natural conditions through a strong mobility, a short life cycle and a high offspring survival probability. The second one is composed of opportunistic species, also with a relatively short life span, among which many are pioneer species which are not very habitat-specific. The third group is composed of species which require many years or even decades to achieve. DIVAnd version 2.1.0 was used to interpolate the observations to maps: Alexander Barth. (2018, September 3). Gher-ulg/DIVAnd.jl: v2.1.0 (Version v2.1.0). Zenodo. http://doi.org/10.5281/zenodo.1407912
DOI: 10.5281/zenodo.3406558
title: Dataset related to article "Phenotypic and molecular changes in nodule-in-nodule hepatocellular carcinoma with pathogenetic implications"

description: This record contains raw data related to article "Phenotypic and molecular changes in nodule-in-nodule hepatocellular carcinoma with pathogenetic implications" AIMS: Nodule-in-nodule (N/N) hepatocellular carcinoma (HCC) is a convincing proof of multistep hepatocarcinogenesis. In this lesion, an inner HCC develops within an outer, more differentiated, tumour, which can be rapidly taken over by the former so that N/N HCC is rarely detected. METHODS AND RESULTS: Ten resected N/N HCCs arising in cirrhotic background and characterized: (i) as outer lesions by early (n = 3) and G1 (n = 7) HCC; (ii) as inner lesions by G1 (n = 3) and G2 (n = 7) HCC. The largest/smallest diameters of outer and inner nodules were, respectively, 20/6 mm and 16/4 mm. We investigated vascular (CD34 and endocan), hepatocellular VEGF, GS, GPC3, HSP70 and CHC) and molecular (TERT promoter and β-catenin) changes taking place from the outer neoplastic compartment to the inner neoplastic compartment (INC). A diffuse pattern of CD34+ capillarized vessels and focal endocan immunoreactivity were major distinctive features acquired in the INC; VEGF immunoreactivity was inversely related to CD34 staining. A gain in the number of cells immunoreactive for GPC3, HSP70, and CHC, but not of GS-immunoreactive cells, also occurred in the INC. TERT promoter mutations were seen in half of the cases in both compartments, whereas β-catenin mutations were more rarely detectable. CONCLUSIONS: Major phenotypic changes take place in the INC of N/N HCC. TERT promoter mutations take place frequently and very early, and, in contrast to β-catenin mutations, do not appear to be acquired during N/N growth. These findings suggest that inner nodules represent a step further along the pathway of tumour progression, in contrast to earlier, simply initiated, lesions, and that complete neovascularisation predicts a change in HCC biology.
DOI: 10.14284/374
title: Distribution of fish living modes in European seas

description: This series of products displays the distributions of the main functional types of benthic and bentho-pelagic fish species derived from a multivariate analysis of eight life history traits. Species data from the International Bottom Trawl Survey data base was combined with a compiled list of life history traits. A multivariate analysis of the life history traits revealed four main living modes. Interpolated maps of the relative distribution of the four living modes were generated in DIVAnd, the n-dimensional Data Interpolating Variational Analysis tool.
description: The first and second groups comprise small species with a short life cycle. Species from group one differ from those from group two by a reduced fecundity compensated by either internal incubation or benthic embryonic development that increase juvenile survival, whereas species from group two are characterised by higher fecundity and juvenile mortality (unattended pelagic eggs). By contrast, groups three and four comprise large and long-lived species. Species from these groups also differ in fecundity, higher in group three, and juvenile survival, higher in group four. Group four is exclusively composed of elasmobranchs (rays, squates and sharks) which either internally incubate a few offspring that they release as adult-miniatures or release large eggs in strongly protective cases fixed on the sea floor. DIVAnd version 2.1.0 was used to generate the interpolated maps: Alexander Barth. (2018, September 3). Gher-ulg/DIVAnd.jl: v2.1.0 (Version v2.1.0). Zenodo. Http://doi.org/10.5281/zenodo.1407912
DOI: 10.5281/zenodo.3406557
title: Dataset related to article "Phenotypic and molecular changes in nodule-in-nodule hepatocellular carcinoma with pathogenetic implications"

description: This record contains raw data related to article "Phenotypic and molecular changes in nodule-in-nodule hepatocellular carcinoma with pathogenetic implications" AIMS: Nodule-in-nodule (N/N) hepatocellular carcinoma (HCC) is a convincing proof of multistep hepatocarcinogenesis. In this lesion, an inner HCC develops within an outer, more differentiated, tumour, which can be rapidly taken over by the former so that N/N HCC is rarely detected. METHODS AND RESULTS: Ten resected N/N HCCs arising in cirrhotic background and characterized: (i) as outer lesions by early (n = 3) and G1 (n = 7) HCC; (ii) as inner lesions by G1 (n = 3) and G2 (n = 7) HCC. The largest/smallest diameters of outer and inner nodules were, respectively, 20/6 mm and 16/4 mm. We investigated vascular (CD34 and endocan), hepatocellular VEGF, GS, GPC3, HSP70 and CHC) and molecular (TERT promoter and β-catenin) changes taking place from the outer neoplastic compartment to the inner neoplastic compartment (INC). A diffuse pattern of CD34+ capillarized vessels and focal endocan immunoreactivity were major distinctive features acquired in the INC; VEGF immunoreactivity was inversely related to CD34 staining. A gain in the number of cells immunoreactive for GPC3, HSP70, and CHC, but not of GS-immunoreactive cells, also occurred in the INC. TERT promoter mutations were seen in half of the cases in both compartments, whereas β-catenin mutations were more rarely detectable. CONCLUSIONS: Major phenotypic changes take place in the INC of N/N HCC. TERT promoter mutations take place frequently and very early, and, in contrast to β-catenin mutations, do not appear to be acquired during N/N growth. These findings suggest that inner nodules represent a step further along the pathway of tumour progression, in contrast to earlier, simply initiated, lesions, and that complete neovascularisation predicts a change in HCC biology.