cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.15468/dl.jeg5re
title: Occurrence Download

description: A dataset containing 164 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Rupicapra pyrenaica ornata Neumann, 1899",
 "HasCoordinate is true",
 "Year is greater than or equal to 2011",
 "Year is less than or equal to 2024"
 ]
}

 The dataset includes 164 records from 3 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0113584-240626123714530/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.5vvz8a
title: Occurrence Download

description: A dataset containing 17 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Isoetes malinverniana Ces. & De Not.",
 "HasCoordinate is true",
 "Year is greater than or equal to 2011",
 "Year is less than or equal to 2024"
 ]
}

 The dataset includes 17 records from 2 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0113585-240626123714530/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.6084/m9.figshare.26893574
title: Thiourea-functionalized aminoglutethimide derivatives as anti-leishmanial agents

description: <b>Aim:</b> We aim to develop new anti-leishmanial agents against <i>Leishmania major</i> and <i>Leishmania tropica</i>. <b>Materials & methods:</b> A total of 23 thiourea derivatives of (±)-aminoglutethimide were synthesized and evaluated for <i>in vitro</i> activity against promastigotes of <i>L. major</i> and <i>L. tropica</i>. <b>Results & conclusion:</b> The <i>N</i>-benzoyl analogue <b>7p</b> was found potent (IC<sub>50</sub> = 12.7 μM) against <i>L. major</i> and non toxic to normal cells. The docking studies, indicates that these inhibitors may target folate and glycolytic pathways of the parasite. The <i>N</i>-hexyl compound <b>7v</b> was found strongly active against both species, and lacked cytotoxicity against normal cells, whereas compound <b>7r</b>, with a 3,5-bis-(tri-fluoro-methyl)phenyl unit, was active against <i>Leishmania</i>, but was cytotoxic in nature. Compound <b>7v</b> was thus identified as a hit for further studies. Leishmaniasis is a protozoal disease exists in three forms, visceral, cutaneous and mucocutaneous. This disease is responsible of thousands of deaths annually. 23 (<b>7a–w</b>) new thiourea derivatives of (±)aminoglutethimide (<b>5</b>) were synthesized by using simple single chemical transformation. All compounds were purified by column chromatography and characterized by using IR, UV, NMR and MS data. All synthesized compounds were evaluated for <i>in vitro</i> activity against promastigotes of <i>Leishmania major</i>, and <i>Leishmania tropica</i> as well as BJ human normal cell line. The mechanism of anti-leishmanial activity of these compounds was predicted by docking studies, indicating that these inhibitors may target folate and glycolytic pathways of the parasite. The <i>N</i>-benzoyl analogue <b>7p</b> was found potent (IC<sub>50</sub> = 12.7 μM) against <i>L. major</i>, with less activity against <i>L. tropica</i>, and nontoxicity to normal human BJ cells. The <i>N</i>-hexyl compound <b>7v</b> was found strongly active against both species, and lacked cytotoxicity against normal cells, whereas compound <b>7r</b>, which contains a 3,5-bis-(tri-fluoro-methyl)phenyl unit, was active against <i>Leishmania</i>, but was cytotoxic in nature. Compound <b>7v</b> was thus identified as a hit for further studies.
DOI: 10.6084/m9.figshare.26893574.v1
title: Thiourea-functionalized aminoglutethimide derivatives as anti-leishmanial agents

description: <b>Aim:</b> We aim to develop new anti-leishmanial agents against <i>Leishmania major</i> and <i>Leishmania tropica</i>. <b>Materials & methods:</b> A total of 23 thiourea derivatives of (±)-aminoglutethimide were synthesized and evaluated for <i>in vitro</i> activity against promastigotes of <i>L. major</i> and <i>L. tropica</i>. <b>Results & conclusion:</b> The <i>N</i>-benzoyl analogue <b>7p</b> was found potent (IC<sub>50</sub> = 12.7 μM) against <i>L. major</i> and non toxic to normal cells. The docking studies, indicates that these inhibitors may target folate and glycolytic pathways of the parasite. The <i>N</i>-hexyl compound <b>7v</b> was found strongly active against both species, and lacked cytotoxicity against normal cells, whereas compound <b>7r</b>, with a 3,5-bis-(tri-fluoro-methyl)phenyl unit, was active against <i>Leishmania</i>, but was cytotoxic in nature. Compound <b>7v</b> was thus identified as a hit for further studies. Leishmaniasis is a protozoal disease exists in three forms, visceral, cutaneous and mucocutaneous. This disease is responsible of thousands of deaths annually. 23 (<b>7a–w</b>) new thiourea derivatives of (±)aminoglutethimide (<b>5</b>) were synthesized by using simple single chemical transformation. All compounds were purified by column chromatography and characterized by using IR, UV, NMR and MS data. All synthesized compounds were evaluated for <i>in vitro</i> activity against promastigotes of <i>Leishmania major</i>, and <i>Leishmania tropica</i> as well as BJ human normal cell line. The mechanism of anti-leishmanial activity of these compounds was predicted by docking studies, indicating that these inhibitors may target folate and glycolytic pathways of the parasite. The <i>N</i>-benzoyl analogue <b>7p</b> was found potent (IC<sub>50</sub> = 12.7 μM) against <i>L. major</i>, with less activity against <i>L. tropica</i>, and nontoxicity to normal human BJ cells. The <i>N</i>-hexyl compound <b>7v</b> was found strongly active against both species, and lacked cytotoxicity against normal cells, whereas compound <b>7r</b>, which contains a 3,5-bis-(tri-fluoro-methyl)phenyl unit, was active against <i>Leishmania</i>, but was cytotoxic in nature. Compound <b>7v</b> was thus identified as a hit for further studies.
DOI: 10.6084/m9.figshare.26893595
title: DNA methylation of miR-181a-5p mediated by DNMT3b drives renal interstitial fibrosis developed from acute kidney injury

description: <b>Aim:</b> To explore the role of miR-181a-5p in the progression of acute kidney injury (AKI) to renal interstitial fibrosis (RIF) from the perspective of DNA methylation. <b>Materials & methods:</b> The role of miR-181a-5p was confirmed by collecting clinical samples, injecting miR-181a-5p agomir into tail vein, and transfecting miR-181a-5p mimic <i>in vitro</i>. The mechanism of miR-181a-5p’s influence on AKI induced RIF was investigated by methylation-specific PCR, bioinformatic analysis, transcriptome sequencing and so on. <b>Results:</b> MiR-181a-5p plays an important role in AKI induced RIF. DNMT3b-mediated miR-181a-5p promoter hypermethylation is the main reason for the downregulation of miR-181a-5p. HDAC9 and SNAI2 are direct targets of miR-181a-5p. <b>Conclusion:</b> Hypermethylation of miR-181a-5p promoter mediated by DNMT3b promotes AKI induced RIF by targeting HDAC9 and SNAI2. Renal interstitial fibrosis (RIF) is a common pathway in the progression of almost all types of chronic kidney disease (CKD) to end-stage renal disease, which severely threatens human health. Acute kidney injury (AKI) is a common clinical syndrome, which is closely correlated with the progression of RIF. However, the underlying mechanism of AKI-inducing RIF remains unclear. miR-181a-5p expression levels in the urine of AKI-CKD patients were significantly decreased compared with that of healthy volunteers. Compared with the control group, I/R mice showed decreased renal function, pathological damage of kidney tissue, and abnormal expression levels of fibrosis related proteins in kidney tissue. miR-181a-5p expression levels in I/R mice were significantly decreased compared with the Sham group. Serum creatinine and blood urea nitrogen levels were higher after I/R injury in mice, and these two indicators showed a significant decrease trend after miR-181a-5p agomir treatment. I/R led to dilation of renal tubules, sloughing of renal tubular epithelial cells (RTEC) and infiltration of inflammatory cells in the renal stroma interstitium, while overexpression of miR-181a-5p alleviated these phenomena. Over-expression of miR-181a-5p significantly restored the levels of fibrosis markers in kidney tissue. miR-181a-5p mimic treatment markedly blunted the motility of RTEC. Over-expression of miR-181a-5p significantly restored the levels of fibrosis markers in RTEC. TGF-β1 induced hypermethylation of the miR-181a-5p promoter. DNMT3b was significantly upregulated in the kidney tissue of CKD patients and RTEC that developed epithelial–mesenchymal transition. Aza, which inhibits DNMT3b activity, significantly restored the loss of miR-181a-5p. HDAC9 and SNAI2 were identified as the direct targets of miR-181a-5p. Hypermethylation of miR-181a-5p promoter mediated by DNMT3b promotes RIF developed from AKI by targeting HDAC9 and SNAI2. We anticipate that argeting the DNMT3B/miR-181a-5p/HDAC9 and SNAI2 pathway may represent a new effective therapeutic option for treating RIF developed from AKI.
DOI: 10.15468/dl.92xmtg
title: Occurrence Download

description: A dataset containing 31 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Abies nebrodensis (Lojac.) Mattei",
 "HasCoordinate is true",
 "Year is greater than or equal to 2011",
 "Year is less than or equal to 2024"
 ]
}

 The dataset includes 31 records from 6 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0113586-240626123714530/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.6084/m9.figshare.26893595.v1
title: DNA methylation of miR-181a-5p mediated by DNMT3b drives renal interstitial fibrosis developed from acute kidney injury

description: <b>Aim:</b> To explore the role of miR-181a-5p in the progression of acute kidney injury (AKI) to renal interstitial fibrosis (RIF) from the perspective of DNA methylation. <b>Materials & methods:</b> The role of miR-181a-5p was confirmed by collecting clinical samples, injecting miR-181a-5p agomir into tail vein, and transfecting miR-181a-5p mimic <i>in vitro</i>. The mechanism of miR-181a-5p’s influence on AKI induced RIF was investigated by methylation-specific PCR, bioinformatic analysis, transcriptome sequencing and so on. <b>Results:</b> MiR-181a-5p plays an important role in AKI induced RIF. DNMT3b-mediated miR-181a-5p promoter hypermethylation is the main reason for the downregulation of miR-181a-5p. HDAC9 and SNAI2 are direct targets of miR-181a-5p. <b>Conclusion:</b> Hypermethylation of miR-181a-5p promoter mediated by DNMT3b promotes AKI induced RIF by targeting HDAC9 and SNAI2. Renal interstitial fibrosis (RIF) is a common pathway in the progression of almost all types of chronic kidney disease (CKD) to end-stage renal disease, which severely threatens human health. Acute kidney injury (AKI) is a common clinical syndrome, which is closely correlated with the progression of RIF. However, the underlying mechanism of AKI-inducing RIF remains unclear. miR-181a-5p expression levels in the urine of AKI-CKD patients were significantly decreased compared with that of healthy volunteers. Compared with the control group, I/R mice showed decreased renal function, pathological damage of kidney tissue, and abnormal expression levels of fibrosis related proteins in kidney tissue. miR-181a-5p expression levels in I/R mice were significantly decreased compared with the Sham group. Serum creatinine and blood urea nitrogen levels were higher after I/R injury in mice, and these two indicators showed a significant decrease trend after miR-181a-5p agomir treatment. I/R led to dilation of renal tubules, sloughing of renal tubular epithelial cells (RTEC) and infiltration of inflammatory cells in the renal stroma interstitium, while overexpression of miR-181a-5p alleviated these phenomena. Over-expression of miR-181a-5p significantly restored the levels of fibrosis markers in kidney tissue. miR-181a-5p mimic treatment markedly blunted the motility of RTEC. Over-expression of miR-181a-5p significantly restored the levels of fibrosis markers in RTEC. TGF-β1 induced hypermethylation of the miR-181a-5p promoter. DNMT3b was significantly upregulated in the kidney tissue of CKD patients and RTEC that developed epithelial–mesenchymal transition. Aza, which inhibits DNMT3b activity, significantly restored the loss of miR-181a-5p. HDAC9 and SNAI2 were identified as the direct targets of miR-181a-5p. Hypermethylation of miR-181a-5p promoter mediated by DNMT3b promotes RIF developed from AKI by targeting HDAC9 and SNAI2. We anticipate that argeting the DNMT3B/miR-181a-5p/HDAC9 and SNAI2 pathway may represent a new effective therapeutic option for treating RIF developed from AKI.
DOI: 10.6084/m9.figshare.26893634
title: Epigenetics: the missing link between environmental exposures and Parkinson's disease?

description: Epigenetics: the missing link between environmental exposures and Parkinson's disease?
DOI: 10.6084/m9.figshare.26893637
title: Epigenetic silencing of <i>KCTD8</i> promotes hepatocellular carcinoma growth by activating PI3K/AKT signaling

description: <b>Aim:</b> The aim of current study is to explore the epigenetic changes and function of KCTD8 in human hepatocellular carcinoma (HCC). <b>Materials & methods:</b> HCC cell lines and tissue samples were employed. Methylation specific PCR, flow cytometry, immunoprecipitation and xenograft mouse models were used. <b>Results:</b><i>KCTD8</i> was methylated in 44.83% (104/232) of HCC and its methylation may act as an independent poor prognostic marker. KCTD8 expression was regulated by DNA methylation. KCTD8 suppressed HCC cell growth both <i>in vitro</i> and <i>in vivo</i> via inhibiting PI3K/AKT pathway. <b>Conclusion:</b> Methylation of <i>KCTD8</i> is an independent poor prognostic marker, and epigenetic silencing of KCTD8 increases the malignant tendency in HCC. Epigenetic dysregulation is a new hallmark for cancer therapy. Classical epi-drugs are mainly targeting epigenetic regulators, without tumor cell specificity. Deep understanding the role of epigenetic regulation in cancer-related signaling pathways may provide novel therapeutic targets. <i>KCTD8</i> is frequently methylated in HCC. KCTD8 methylation is an independent poor prognostic biomarker in HCC. KCTD8 inhibits HCC cells growth both <i>in vitro</i> and <i>in vivo</i>. Epigenetic silencing of <i>KCTD8</i> activates PI3K/AKT signaling pathway in HCC. <i>KCTD8</i> is a novel tumor suppressor in HCC.
DOI: 10.6084/m9.figshare.26893637.v1
title: Epigenetic silencing of <i>KCTD8</i> promotes hepatocellular carcinoma growth by activating PI3K/AKT signaling

description: <b>Aim:</b> The aim of current study is to explore the epigenetic changes and function of KCTD8 in human hepatocellular carcinoma (HCC). <b>Materials & methods:</b> HCC cell lines and tissue samples were employed. Methylation specific PCR, flow cytometry, immunoprecipitation and xenograft mouse models were used. <b>Results:</b><i>KCTD8</i> was methylated in 44.83% (104/232) of HCC and its methylation may act as an independent poor prognostic marker. KCTD8 expression was regulated by DNA methylation. KCTD8 suppressed HCC cell growth both <i>in vitro</i> and <i>in vivo</i> via inhibiting PI3K/AKT pathway. <b>Conclusion:</b> Methylation of <i>KCTD8</i> is an independent poor prognostic marker, and epigenetic silencing of KCTD8 increases the malignant tendency in HCC. Epigenetic dysregulation is a new hallmark for cancer therapy. Classical epi-drugs are mainly targeting epigenetic regulators, without tumor cell specificity. Deep understanding the role of epigenetic regulation in cancer-related signaling pathways may provide novel therapeutic targets. <i>KCTD8</i> is frequently methylated in HCC. KCTD8 methylation is an independent poor prognostic biomarker in HCC. KCTD8 inhibits HCC cells growth both <i>in vitro</i> and <i>in vivo</i>. Epigenetic silencing of <i>KCTD8</i> activates PI3K/AKT signaling pathway in HCC. <i>KCTD8</i> is a novel tumor suppressor in HCC.
DOI: 10.6084/m9.figshare.26893634.v1
title: Epigenetics: the missing link between environmental exposures and Parkinson's disease?

description: Epigenetics: the missing link between environmental exposures and Parkinson's disease?
DOI: 10.15468/dl.4tm8ga
title: Occurrence Download

description: A dataset containing 4 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Salicornia veneta Pignatti & Lausi",
 "HasCoordinate is true",
 "Year is greater than or equal to 2011",
 "Year is less than or equal to 2024"
 ]
}

 The dataset includes 4 records from 2 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0113588-240626123714530/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.wrqhk8
title: Occurrence Download

description: A dataset containing 2019 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Parkia timoriana (DC.) Merr."
 ]
}

 The dataset includes 2019 records from 86 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0113587-240626123714530/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.5281/zenodo.13628015
title: Social Comparison, Loneliness and Social Media Use

description: Total scale score and demographic factors from a cross-sectional survey study.
DOI: 10.5281/zenodo.13628016
title: Social Comparison, Loneliness and Social Media Use

description: Total scale score and demographic factors from a cross-sectional survey study.
DOI: 10.15468/dl.kvqdbp
title: Occurrence Download

description: A dataset containing 1 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Silene hicesiae Brullo & Signor.",
 "HasCoordinate is true",
 "Year is greater than or equal to 2011",
 "Year is less than or equal to 2024"
 ]
}

 The dataset includes 1 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0113589-240626123714530/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.48544/b862c4c7-9c62-4515-9d25-65f600f01e75
title: Empty Farm to Fill. Ontwerpprincipes voor pedagogische vrijplaatsen, om samen met jongeren te kunnen werken aan een veerkrachtige identiteitsontwikkeling.
DOI: 10.15468/dl.vz6f2v
title: Occurrence Download

description: A dataset containing 9 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Adonis distorta Ten.",
 "HasCoordinate is true",
 "Year is greater than or equal to 2011",
 "Year is less than or equal to 2024"
 ]
}

 The dataset includes 9 records from 4 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0113590-240626123714530/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.48331/scielodata.jtaakh
title: Replication Data for: Synopsis of Myrcia s.l. (Myrtaceae) in the state of Pernambuco, Brazil

description: This readme file was generated on 2023-10-05 by Rafaela Alves Pereira da Silva GENERAL INFORMATION Title of Dataset: Analyzed material for the Synopsis of Myrcia s.l. (Myrtaceae) in the state of Pernambuco, Brazil. Author/Principal Investigator Information Name: Juliana Gleice dos Santos Alves ORCID:https://orcid.org/0000-0002-5569-2353 Institution:Unidade Acadêmica de Serra Talhada Address: Av. Gregório Ferraz Nogueira, s/n - Serra Talhada, PE, 56909-535 Email: julianagleicealves@hotmail.com Author/Associate or Co-investigator Information Name: Rafaela Alves Pereira da Silva ORCID:https://orcid.org/0000-0001-6622-8372 Institution: Unidade Acadêmica de Serra Talhada Address: Av. Gregório Ferraz Nogueira, s/n - Serra Talhada, PE, 56909-535 Email: rafaela.news1@gmail.com Author/Alternate Contact Information Name: André Laurênio de Melo ORCID:https://orcid.org/0000-0003-4267-5818 Institution: Unidade Acadêmica de Serra Talhada Address:Av. Gregório Ferraz Nogueira, s/n - Serra Talhada, PE, 56909-535 Email: andrelaurenio@yahoo.com.br Date of data collection: 2022-12-20 Geographic location of data collection: -6.6045949,-42.1729747, Pernambuco, Brazil Information about funding sources that supported the collection of the data: Not aplied The "Material Suplementar_Myrcia.xlsx" contains the data of the examinated material for the descriptions of the species, beyond catalog numer, collector and their names and the coordinates of studied species. Description In Pernambuco, Myrcia is the largest genus of Myrtaceae with 28 species, followed by Eugenia with 25 species (Flora do Brasil 2020). The state is divided into four phytogeographic zones, predominantly Atlantic Forest and Caatinga. However, studies with representatives of Myrcia in Pernambuco are scarce and punctuaL. In this context, this work aims to carry out a synopsis of Myrcia for the state of Pernambuco. Methodological Information About 1000 specimens of the genus Myrcia were raised and analyzed for the state of Pernambuco deposited in the herbaria. Collections were also carried out in some municipalities of the state. Collections followed usual techniques in plant taxonomy (Mori et al. 1989), and the material was pressed, dehydrated and incorporated into the HESBRA collection. Keywords Caatinga, Atlantic Florest, Myrtales, Myrteae, Taxonomy SHARING/ACCESS INFORMATION Related Publication Synopsis of Myrcia s.l. (Myrtaceae) in the state of Pernambuco, Brazil Was data derived from another source? Not aplied Depositor Rafaela Alves Pereira da Silva Deposit Data 2023-10-05
DOI: 10.48331/scielodata.jtaakh/0jiquv
title: Dados_Myrcia.xls

description: Here there are all the data analyzed of the manuscript.
DOI: 10.48331/scielodata.jtaakh/jzcyof
title: README.txt.txt

description: Title of Dataset: Analyzed material for the Synopsis of Myrcia s.l. (Myrtaceae) in the state of Pernambuco, Brazil.
DOI: 10.15468/dl.z7d672
title: Occurrence Download

description: A dataset containing 1 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Brassica macrocarpa Guss.",
 "HasCoordinate is true",
 "Year is greater than or equal to 2011",
 "Year is less than or equal to 2024"
 ]
}

 The dataset includes 1 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0113591-240626123714530/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.5281/zenodo.13627999
title: Author information for the publication "The Earth BioGenome Project Phase II: Illuminating the Eukaryotic Tree of Life"

description: This Excel format file includes three sheets:

1: CREDIT information for the named authors of the publication "The Earth BioGenome Project Phase II: Illuminating the Eukaryotic Tree of Life"

2: Funding information for the named authors of the publication "The Earth BioGenome Project Phase II: Illuminating the Eukaryotic Tree of Life"

3: A listing of the individuals included in the collective authorship "The EBP Community of Scientists" in the publication "The Earth BioGenome Project Phase II: Illuminating the Eukaryotic Tree of Life"