cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.23375345.v1
title: Supplementary Material for: Long-Term Prognosis and Related Factors in Patients with Cirrhosis Treated with Balloon-Occluded Retrograde Transvenous Obliteration

description: <b><i>Introduction:</i></b> Balloon-occluded retrograde transvenous obliteration (BRTO) was developed as an effective treatment for gastric varices in patients with cirrhosis. Because liver fibrosis in these patients is assumed to be advanced, their prognosis is expected to be poor. In this study, we investigated the prognosis and characteristics of the patients. <b><i>Methods:</i></b> We enrolled 55 consecutive patients with liver cirrhosis treated with BRTO between 2009 and 2021 at our department. To evaluate factors related to variceal recurrence and long-term prognosis, survival analysis was performed on 45 patients, excluding those who died within 1 month, had an unknown prognosis, or whose treatments were converted to other treatments. <b><i>Results:</i></b> During a mean follow-up period of 2.3 years, esophageal varices recurred in 10 patients and could be treated endoscopically. Non-alcoholic steatohepatitis (NASH) was related to the variceal recurrence (hazard ratio [HR] = 4.27, 95% CI: 1.17–15.5, <i>p</i> = 0.028). The survival rate after the procedure at 1, 3, and 5 years was 94.2%, 74.0%, and 63.5%, respectively, and 10 patients died of hepatocellular carcinoma (<i>n</i> = 6), liver failure (<i>n</i> = 1), sepsis (<i>n</i> = 1), and unknown reasons (<i>n</i> = 2). The estimated glomerular filtration rate (eGFR) level was proved to be a significant poor prognostic factor (HR = 0.96, 95% CI: 0.93–0.99, <i>p</i> = 0.023). The comorbid hypertension (HTN) was the main cause of low eGFR, and HTN was also significantly related to survival (HR = 6.18, 95% CI: 1.57–24.3, <i>p</i> = 0.009). Most of the patients with HTN were treated with calcium channel blocker and/or angiotensin receptor blocker. <b><i>Conclusion:</i></b> The clinical course of patients with cirrhosis treated with BRTO was dependent on the metabolic factors including renal function, comorbid HTN, and NASH.
DOI: 10.6084/m9.figshare.14502135.v2
title: Molecular Dynamic Characteristic Temperatures for Predicting Metallic Glass Forming Ability

description: Plots, data, and models used throughout a molecular dynamics study of characteristic temperatures to quantify glass forming ability for metallic alloys.
DOI: 10.6084/m9.figshare.15157647.v1
title: Project1.pzfx

description: cancer research<br>
DOI: 10.6084/m9.figshare.27199623.v1
title: Raw data.rar

description: <b>Revolutionizing Cervical Cancer Diagnostics with Deep Learning: The Impact of SEResNet101 and SE-VGG19 on Lesion Classification</b>
DOI: 10.60893/figshare.jcp.27011407.v1
title: Supplement Number 1

description: Experimental details, models of the ultrathin film geometries, tentative estimates of the relaxation time in the surface layer, and additional comments.
DOI: 10.6084/m9.figshare.20231208.v1
title: Lingtai temperature records.xlsx

description: Lingtai GDGTs-derived Land Temperature
DOI: 10.6084/m9.figshare.7149167.v2
title: Characterizing the pathogenic, genomic, and chemical traits of Aspergillus fischeri, a close relative of the major human fungal pathogen Aspergillus fumigatus

description: <i>Aspergillus fischeri </i>is a close evolutionary relative of the major cause of invasive mold infections, <i>Aspergillus fumigatus</i>. In contrast to <i>A. fumigatus</i>, <i>A. fischeri </i>rarely causes invasive disease even though it is commonly found in diverse environments, including hospitals. Thus, it remains unclear why <i>A. fischeri </i>causes less human disease. To begin addressing this question, we characterized the pathogenic, genomic, and secondary metabolic similarities and differences between <i>A. fischeri </i>and <i>A. fumigatus</i>. We observed multiple differences between the two species for phenotypes related to pathogenesis, including that <i>A. fischeri </i>is less virulent than <i>A. fumigatus </i>in multiple murine models of invasive disease, exhibits slower growth in low oxygen environments, and is more sensitive to oxidative stress. In contrast, the genomic similarity between the two species is high; ~90% of the <i>A. fumigatus </i>proteome is conserved in <i>A. fischeri</i>, including 48 / 49 genes known to be involved in <i>A. fumigatus </i>virulence. However, only 10 / 33 <i>A. fumigatus </i>biosynthetic gene clusters (BGCs) likely involved in the production of secondary metabolites are conserved in <i>A. fischeri </i>and only 13 / 48 <i>A. fischeri </i>BGCs are conserved in <i>A. fumigatus</i>. Detailed chemical characterization of <i>A. fischeri </i>cultures grown on multiple substrates identified multiple secondary metabolites, including two new compounds and one never before isolated as a natural product. Interestingly, an <i>A. fischeri </i>deletion mutant of <i>laeA</i>, a master regulator of secondary metabolism, produced fewer secondary metabolites and in lower quantities, suggesting that regulation of secondary metabolism is at least partially conserved between the two species. These results suggest that the non-pathogenic <i>A. fischeri </i>possesses many of the genes important for <i>A. fumigatus </i>pathogenicity but is divergent with respect to its ability to thrive under host-relevant conditions and its secondary metabolism. <br>
DOI: 10.6084/m9.figshare.22294240.v1
title: Locations of Ocinara Varians.docx

description: Locations of Ocinara Varians
DOI: 10.6084/m9.figshare.14124017.v1
title: the prevalence of depression in cervical cancer Northern Thailand

description: the dataset of the study title "the prevalence of depression in cervical cancer Northern Thailand"
DOI: 10.17632/3xxswjcwfd
title: P-O Fit, Turnover Intention, Well-Being

description: In this data there are 515 teacher responses for their P-E fit levels, well-being, job satisfaction, their turnover intentions.
DOI: 10.6084/m9.figshare.11663892.v1
title: Draft Genome of Funaria hygrometrica

description: This repository contains the draft genome sequence of Funaria hygrometrica, the gtf file containing gene and transcript coordinates, assembled transcript sequences and their best protein translations. Full description of the data files are provided in the Readme.txt file.
DOI: 10.6084/m9.figshare.25060211.v1
title: Supplementary Material for: Association of Cancer and Its Interaction with Conventional Risk Factors on Cardiovascular Disease Risk

description: Introduction We sought to examine the association of cancer history with the incidence of individual cardiovascular disease events and to clarify whether the history of cancer modifies the relationship between conventional cardiovascular risk factors and incident cardiovascular disease. 
Methods This retrospective cohort study used the JMDC Claims Database, including 3,531,683 individuals. The primary endpoint was the composite cardiovascular disease outcome, which included myocardial infarction, angina pectoris, stroke, heart failure, and atrial fibrillation. 
Results During a follow-up, 144,162 composite endpoints were recorded. Individuals with a history of cancer had a higher risk of developing composite cardiovascular disease events (HR 1.26, 95% CI 1.22-1.29). The HRs for myocardial infarction, angina pectoris, stroke, heart failure, and atrial fibrillation were 1.11 (95% CI 0.98-1.27), 1.15 (95% CI 1.10-1.20), 1.11 (95% CI 1.05-1.18), 1.39 (95% CI 1.34-1.44), and 1.22 (95% CI 1.13-1.32), respectively. Individuals who required chemotherapy for cancer had a higher risk of developing cardiovascular disease. Although conventional risk factors (e.g., overweight/obesity, hypertension, and diabetes) were associated with incident composite cardiovascular disease even in individuals with a history of cancer, the total population-attributable fractions of conventional risk factors were less in individuals with a history of cancer. 
Conclusion Individuals with a history of cancer (particularly those requiring chemotherapy) have a higher risk of cardiovascular disease. Traditional risk factors are important in the development of cardiovascular disease in individuals with and without a history of cancer. In individuals with a history of cancer, however, the total population-attributable fractions of conventional risk factors decreased.
DOI: 10.11583/dtu.20177912.v1
title: Northern European AC/DC power system model with a North Sea Wind Power Hub

description: In many power systems, the increased penetration of inverter-based renewable generation will cause a decrease in kinetic energy storage, leading to higher frequency excursions after a power disturbance. This is the case of the future Nordic Power System (NPS). The look-ahead study reported in [1] shows that the chosen units participating in Frequency Containment Reserves (FCR) cannot keep the frequency above the prescribed threshold following the outage of the largest plant. This analysis relies on this detailed model of the Northern European grid. The model includes the HVDC links that connect the NPS to the rest of the European grid and the HVDC links are equipped with an emergency power controller, which can supplement or even replace part of the FCR. Moreover, the model includes the future North Sea Wind Power Hub under two configurations, namely low and zero inertia, which is connected through HVDC links. The model is provided in PowerFactory format and is publicly available. <br> Citeable as: [1] D. Obradovic, M. Dijokas, G. Misyris, T. Weckesser and T. Van Cutsem, "Frequency dynamics of the Northern European AC/DC power system: a look-ahead study," in <em>IEEE Transactions on Power Systems</em>, doi: 10.1109/TPWRS.2022.3154720.
DOI: 10.6084/m9.figshare.25289404.v3
title: MArine Bioprospecting PATent dataset

description: The goal of the MABPAT database is to provide a useful insight into the scope and scale of marine bioprospecting. We offer the research and practitioner community with direct access to marine genetic sequences submitted to patent bureaus, their potential to encode biological functions, species taxonomy, type of applicant, and other information that might be relevant for the discussion on the access and utilization of marine genetic resources.Erik Zhivkoplias, Agnes Pranindita, Paul Dunshirn et al. Novel database reveals growing prominence of deep-sea life for marine bioprospecting, https://doi.org/10.21203/rs.3.rs-3136354/v1
DOI: 10.6084/m9.figshare.19713841.v1
title: Supplementary Material for: Innate Immune Responses to RSV Infection Facilitated by OGG1, an Enzyme Repairing Oxidatively Modified DNA Base Lesions

description: The primary cause of morbidity and mortality from infection with respiratory syncytial virus (RSV) is the excessive innate immune response(s) (IIR) in which reactive oxygen species (ROS) play key role(s). However, the mechanisms for these processes are not fully understood. We hypothesized that expressions of IIR genes are controlled by the ROS-generated epigenetic-like mark 7,8-dihydro-8-oxo(d)guanine (8-oxo(d)Gua) and 8-oxoguanine DNA glycosylase1 (OGG1). Here, we report that ROS not only generates intrahelical 8-oxo(d)Gua, but also enzymatically disables OGG1 in RSV-infected human airway epithelial cells and mouse lungs. OGG1 bound to 8-oxo(d)Gua in gene regulatory sequences promotes expression of IIR genes, and consequently exacerbates lung inflammation, histological changes, and body weight loss of experimental animals. Pharmacological inhibition of OGG1 substrate binding decreased expression of RSV-induced chemokine and cytokines and significantly lessened clinical symptoms. Results of mechanistic studies show that OGG1 binding at 8-oxo(d)Gua promoter regions modulated loading of transcription factors via transient cooperative interactions in RSV-infected lungs and airway epithelial cells. Other base specific DNA repair proteins had no effects. Collectively, this study identifies unprecedented roles of ROS-generated DNA base lesion(s) and cognate repair protein as a determinant of RSV-induced exuberant inflammation. Pharmaceutical inhibition of OGG1 interaction with its DNA substrate may represent a novel strategy in prevention/intervention of respiratory viral infections.
DOI: 10.6084/m9.figshare.21679238.v2
title: SERUM PROGESTERONE CONCENTRATION THE DAY PRIOR TO FROZEN EMBRYO TRANSFER AND PREGNANCY OUTCOMES

description: <strong>SERUM PROGESTERONE CONCENTRATION THE DAY PRIOR TO FROZEN EMBRYO TRANSFER AND PREGNANCY OUTCOMES: A PROSPECTIVE COHORT STUDY</strong>
DOI: 10.6084/m9.figshare.24161937.v1
title: The influence of deoxygenation on Caribbean coral larval settlement and early survival

description: This data set was collected at the Smithsonian Marine Station (SMS), Fort Pierce, Florida between August - October 2022. Coral larvae were exposed to deoxygenation (simulated low-oxygen conditions) in the SMS mesocosm facility. For full description of the study see: Mallon et al., (2023), The influence of deoxygenation on Caribbean coral larval settlement and early survival, Front. Mar. Sci. Sec. Global Change and the Future Ocean, Volume 10 - 2023 | doi: 10.3389/fmars.2023.1254965
DOI: 10.17632/rmrcrtp76p
title: The Prime Minister of Iraq Dr. Haider Al-Abadi, Political Semantics of his speeches

description: This Data gathered from the prime minister Haider Al-Abadi’s speeches, retrieved from “Media Office of Iraqi Prime Minister Haider Abadi” source in Arabic language, and translated literally into English language, in order to interpret semantic discourse peculiarities of his presidential speeches to the Iraqis, according to ‘political communication theory’. In addition, to identify his persuasive communication methods that he used.
DOI: 10.6084/m9.figshare.16649671.v2
title: Network: lter, Domain: konza

description: MacroSheds timeseries data, shapefiles, and metadata for domain: konza, within network: lter
DOI: 10.6084/m9.figshare.27888777.v1
title: Supplementary Material for: The MAASWERP study: An international, comparative case study on measuring biomechanics of the aged murine aorta

description: Introduction: Arterial stiffening is a hallmark of vascular ageing, and unravelling its underlying mechanisms has become a central theme in the field of cardiovascular disease. While various techniques and experimental setups are accessible for investigating biomechanics of blood vessels both in vivo and ex vivo, comparing findings across diverse methodologies is challenging.
Methods: Arterial stiffness in the aorta of adult (5 months) and aged (24 months) wild-type C57Bl/6J mice was measured in vivo, after which ex vivo biomechanical evaluation was performed using the Rodent Oscillatory Tension Setup to study Arterial Compliance (ROTSAC; University of Antwerp, Belgium) and the DynamX setup (Maastricht University, The Netherlands). Stiffness of aortic tissue was measured in both absence an presence of activated smooth muscle cells (i.e., contraction). Measurements in both setups were conducted in parallel with matched protocols and identical buffers and chemicals.
Results: Overall, both methods revealed age-related increased aortic stiffness, although parameters of aortic mechanics showed different numerical values, suggesting that results are not directly interchangeable between methods. Surprisingly, smooth muscle cell contraction had opposing effects between the setups. Indeed, smooth muscle cell contraction increased arterial stiffness in the ROTSAC but decreased stiffness in the DynamX. These opposing effects could be attributed to how the two setups differentially load the collagen fibres in the arterial wall, ex vivo.
Conclusion: Overall, this study provided critical insights into how different experimental setups can influence the interpretation of aortic biomechanics, emphasizing the need for careful consideration and contextualization of results based on the methodology used.
DOI: 10.6084/m9.figshare.7565171.v1
title: Supplementary Material for: The miR-183/96/182 Cluster Regulates Macrophage Functions in Response to <b><i>Pseudomonas aeruginosa</i></b>

description: Macrophages (Mϕ) are an important component of the innate immune system; they play critical roles in the first line of defense to pathogen invasion and modulate adaptive immunity. MicroRNAs (miRNAs) are a newly recognized, important level of gene expression regulation. However, their roles in the regulation of Mϕ and the immune system are still not fully understood. In this report, we provide evidence that the conserved miR-183/96/182 cluster (miR-183/96/182) modulates Mϕ function in their production of reactive nitrogen (RNS) and oxygen species (ROS) and their inflammatory response to <i>Pseudomonas aeruginosa</i> (PA) infection and/or lipopolysaccharide (LPS) treatment. We show that knockdown of miR-183/96/182 results in decreased production of multiple proinflammatory cytokines in response to PA or LPS treatment in Mϕ-like Raw264.7 cells. Consistently, peritoneal Mϕ from miR-183/96/182-knockout versus wild-type mice are less responsive to PA or LPS<b><i>,</i></b> although their basal levels of proinflammatory cytokines are increased. In addition, overexpression of miR-183/96/182 results in decreased production of nitrite and ROS in Raw264.7 cells. We also provide evidence that DAP12 and Nox2 are downstream target genes of miR-183/96/182. These data suggest that miR-183/96/182 imposes global regulation on various aspects of Mϕ function through different downstream target genes.
DOI: 10.6084/m9.figshare.7944224.v1
title: Supplementary Material for: High-Sensitivity C-Reactive Protein and Allergic Endpoints in German Adolescents

description: <b><i>Background:</i></b> Assessing high-sensitivity C-reactive protein (hs-CRP) in relation to allergic endpoints can shed light on both the mechanisms of allergic disease development and early non-communicable disease prevention. However, only a few epidemiological studies so far have investigated the relationship in children and adolescents, and the results were mixed. <b><i>Objectives:</i></b> We sought to examine the interrelation between hs-CRP levels and allergic outcomes using a larger population size and a longitudinal study design. <b><i>Methods:</i></b> Complete data were available on 1,955 participants from the 15-years follow-up of the 2 large population-based German birth cohorts – GINIplus and LISA. Serum hs-CRP concentrations were measured using the immunoturbidimetric high-sensitive assay. Six allergic endpoints were used – doctor-diagnosed asthma, doctor-diagnosed eczema, doctor-diagnosed allergic rhinitis, food sensitization, aeroallergen sensitization, and any sensitization. We used generalized estimation equation models<sup></sup> to assess the associations between hs-CRP levels and allergic endpoints. <b><i>Results:</i></b> Our longitudinal analyses did not detect any significant association between hs-CRP levels and any of the studied allergic outcomes (e.g., asthma, eczema, allergic rhinitis, food sensitization, aeroallergen sensitization, and any sensitization). The results were consistent in a series of sensitivity analyses. <b><i>Conclusions:</i></b> Our study suggests that there is no association between hs-CRP levels and any of the allergic endpoints in German adolescents. However, whether allergic diseases are inflammatory conditions and which markers might be most sensitive, remain to be confirmed in future studies.
DOI: 10.6084/m9.figshare.12363878.v2
title: weighted citations by country (researcher affiliations)

description: Fractional citations to all COVID-19 publications by receiving country determined by researcher affiliation. Totals by week in which citations were made. COVID-19 research is defined relative to the boxed query in this report. Only citations from other COVID-19 papers have been considered. All numbers are derived from Dimensions
DOI: 10.6084/m9.figshare.14624661.v1
title: Supplementary Material for: Skin Surface Protein Detection by Transdermal Analysis Patches in Pediatric Psoriasis

description: <b><i>Introduction:</i></b> Transdermal analysis patches (TAPs) noninvasively measure soluble proteins in the stratum corneum. Ultimately, such local protein profiles could benefit the search for biomarkers to improve personalized treatment in psoriasis. This study aimed to explore the patient friendliness and protein detection by TAP in pediatric psoriasis in daily clinical practice. <b><i>Methods:</i></b> In this observational study, TAPs measuring CXC chemokine ligand (CXCL)-1/2, CC chemokine ligand (CCL)-27, interleukin (IL)-1RA, IL-23, IL-1α, IL-8, IL-4, IL-22, IL-17A, vascular endothelial growth factor (VEGF), human beta-defensin (hBD)-2, hBD-1, and kallikrein-related peptidase (KLK)-5 were applied on lesional, peri-lesional, and non-lesional skin sites of psoriasis patients aged &gt;5 to &lt;18 years. Discomfort during TAP removal as an indicator for patient friendliness was assessed by visual analogue scale (VAS; range 0–10). <b><i>Results:</i></b> Thirty-two patients (median age 14.0 years) were included, of which 19 were treated with solely topical agents and 13 with systemic treatment. The median VAS of discomfort during TAP removal was 1.0 (interquartile range 1.0). Significantly higher levels in lesional versus non-lesional skin were found for IL-1RA, VEGF, CXCL-1/2, hBD-2, and IL-8, whereas lower levels were found for IL-1α. Skin surface proteins were measured in both treatment groups, with significant higher lesional levels of KLK-5, IL-1RA, hBD-2, IL-1α, IL-23, and CCL-27 in the systemic treatment group. <b><i>Conclusion:</i></b> The TAP platform holds the potential for patient-friendly and noninvasive monitoring of skin-derived proteins in pediatric psoriasis patients in daily clinical practice.
DOI: 10.6084/m9.figshare.15059325.v1
title: Supplementary Material for: Sarcopenia Is Associated with Mortality in Adults: A Systematic Review and Meta-Analysis

description: <b><i>Background:</i></b> Sarcopenia can predispose individuals to falls, fractures, hospitalization, and mortality. The prevalence of sarcopenia depends on the population studied and the definition used for the diagnosis. <b><i>Objective:</i></b> This systematic review and meta-analysis aimed to investigate the association between sarcopenia and mortality and if it is dependent on the population and sarcopenia definition. <b><i>Methods:</i></b> A systematic search was conducted in MEDLINE, EMBASE, and Cochrane from 1 January 2010 to 6 April 2020 for articles relating to sarcopenia and mortality. Articles were included if they met the following criteria – cohorts with a mean or median age ≥18 years and either of the following sarcopenia definitions: Asian Working Group for Sarcopenia (AWGS and AWGS2019), European Working Group on Sarcopenia in Older People (EWGSOP and EWGSOP2), Foundation for the National Institutes of Health (FNIH), International Working Group for Sarcopenia (IWGS), or Sarcopenia Definition and Outcomes Consortium (SDOC). Hazard ratios (HR) and odds ratios (OR) were pooled separately in meta-analyses using a random-effects model, stratified by population (community-dwelling adults, outpatients, inpatients, and nursing home residents). Subgroup analyses were performed for sarcopenia definition and follow-up period. <b><i>Results:</i></b> Out of 3,025 articles, 57 articles were included in the systematic review and 56 in the meta-analysis (42,108 participants, mean age of 49.4 ± 11.7 to 86.6 ± 1.0 years, 40.3% females). Overall, sarcopenia was associated with a significantly higher risk of mortality (HR: 2.00 [95% CI: 1.71, 2.34]; OR: 2.35 [95% CI: 1.64, 3.37]), which was independent of population, sarcopenia definition, and follow-up period in subgroup analyses. <b><i>Conclusions:</i></b> Sarcopenia is associated with a significantly higher risk of mortality, independent of population and sarcopenia definition, which highlights the need for screening and early diagnosis in all populations.