cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.7270/q2rn3c14
title: BindingDB Entry 10054: Monocyclic thieno, pyrido, and pyrrolo pyrimidine compounds and methods of use and manufacture of same

description: Small molecule binding data for protein Dihydrofolate reductase, Uniprot A0EPY1 and P00374
DOI: 10.7270/q2rn3c2k
title: BindingDB Entry 10441: NOVEL CORONAVIRUS MAIN PROTEASE INHIBITOR, AND PREPARATION METHOD THEREFOR AND USE THEREOF

description: Small molecule binding data for protein Replicase polyprotein 1ab, Uniprot P0DTD1
DOI: 10.7270/q2rn3c31
title: BindingDB Entry 10828: Cyclic compound having dopamine D3 receptor antagonistic effect

description: Small molecule binding data for protein D(2) dopamine receptor and D(3) dopamine receptor, Uniprot P14416 and P35462
DOI: 10.7270/q2rn3c4g
title: BindingDB Entry 50006807: Discovery of a novel azetidine scaffold for colony stimulating factor-1 receptor (CSF-1R) Type II inhibitors by the use of docking models.

description: Small molecule binding data for protein Macrophage colony-stimulating factor 1 receptor, Uniprot P07333
DOI: 10.7270/q2rn3c5x
title: BindingDB Entry 50007072: Biphenyl Acid Derivatives as APJ Receptor Agonists.

description: Small molecule binding data for protein Apelin receptor, Uniprot P35414 and Q9JHG3
DOI: 10.7270/q2rn3c6c
title: BindingDB Entry 50007406: Recent advances in the targeting of human DNA ligase I as a potential new strategy for cancer treatment.

description: Small molecule binding data for protein DNA ligase 1, DNA ligase 3, and DNA ligase 4, Uniprot P18858, P49916, and P49917
DOI: 10.7270/q2rn3c7t
title: BindingDB Entry 50008013: Optimization of Potent ATAD2 and CECR2 Bromodomain Inhibitors with an Atypical Binding Mode.

description: Small molecule binding data for protein ATPase family AAA domain-containing protein 2, ATPase family AAA domain-containing protein 2B, Bromodomain adjacent to zinc finger domain protein 2A, Bromodomain and PHD finger-containing protein 3, Bromodomain-containing protein 1, Bromodomain-containing protein 4, Chromatin remodeling regulator CECR2, Histone acetyltransferase KAT2A, Transcription initiation factor TFIID subunit 1, and Transcription initiation factor TFIID subunit 1-like, Uniprot O60885, O95696, P21675, Q6PL18, Q8IZX4, Q92830, Q9BXF3, Q9UIF9, Q9ULD4, and Q9ULI0
DOI: 10.7270/q2rn3c88
title: BindingDB Entry 50008633: Synthesis and evaluation of third generation vitamin D3 analogues as inhibitors of Hedgehog signaling.

description: Small molecule binding data for protein Vitamin D3 receptor, Uniprot P48281
DOI: 10.7270/q2rn3c9q
title: BindingDB Entry 50009284: Insights on the synthesis of asymmetric curcumin derivatives and their biological activities.

description: Small molecule binding data for protein Carbonic anhydrase 2 and Polyphenol oxidase 2, Uniprot O42713 and P00918
DOI: 10.7270/q2rn3cb5
title: BindingDB Entry 50009890: Discovery and SAR of pyrrolo[2,1-f][1,2,4]triazin-4-amines as potent and selective PI3Kδ inhibitors.

description: Small molecule binding data for protein Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform, Uniprot O00329
DOI: 10.7270/q2rn3ccm
title: BindingDB Entry 50010208: Discovery of 3-(3-(4-(1-Aminocyclobutyl)phenyl)-5-phenyl-3H-imidazo[4,5-b]pyridin-2-yl)pyridin-2-amine (ARQ 092): An Orally Bioavailable, Selective, and Potent Allosteric AKT Inhibitor.

description: Small molecule binding data for protein Cytochrome P450 1A2, Cytochrome P450 2C19, Cytochrome P450 2C8, Cytochrome P450 2C9, Cytochrome P450 2D6, Cytochrome P450 3A4, RAC-alpha serine/threonine-protein kinase, RAC-beta serine/threonine-protein kinase, and RAC-gamma serine/threonine-protein kinase, Uniprot P05177, P08684, P10632, P10635, P11712, P31749, P31751, P33261, and Q9Y243
DOI: 10.7270/q2rn3cd2
title: BindingDB Entry 50010465: Design and synthesis of boron-containing diphenylpyrimidines as potent BTK and JAK3 dual inhibitors.

description: Small molecule binding data for protein Non-receptor tyrosine-protein kinase TYK2, Tyrosine-protein kinase BTK, Tyrosine-protein kinase JAK1, Tyrosine-protein kinase JAK2, and Tyrosine-protein kinase JAK3, Uniprot O60674, P23458, P29597, P52333, and Q06187
DOI: 10.7270/q2rn3cfh
title: BindingDB Entry 50010796: Discovery of Novel PDEδ Degraders for the Treatment of KRAS Mutant Colorectal Cancer.

description: Small molecule binding data for protein Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta, Uniprot O43924
DOI: 10.7270/q2rn3cgz
title: BindingDB Entry 50011428: Screening and Reverse-Engineering of Estrogen Receptor Ligands as Potent Pan-Filovirus Inhibitors.

description: Small molecule binding data for protein Estrogen receptor, Uniprot P03372
DOI: 10.7270/q2rn3chd
title: BindingDB Entry 50012059: Fragment-based lead discovery of a novel class of small molecule antagonists of neuropeptide B/W receptor subtype 1 (GPR7).

description: Small molecule binding data for protein Neuropeptides B/W receptor type 1, Uniprot P48145
DOI: 10.7270/q2rn3cjv
title: BindingDB Entry 50012677: Discovery of a Potent and Selective PI3Kδ Inhibitor (

description: Small molecule binding data for protein Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform, and Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, Uniprot O00329, P42336, P42338, P48736, and Q9JHG7
DOI: 10.7270/q2rn3ck9
title: BindingDB Entry 50013325: A multi-scale systems pharmacology approach uncovers the anti-cancer molecular mechanism of Ixabepilone.

description: Small molecule binding data for protein Apoptosis regulator Bcl-2, Epithelial discoidin domain-containing receptor 1, High affinity nerve growth factor receptor, Macrophage colony-stimulating factor 1 receptor, Platelet-derived growth factor receptor alpha, Proto-oncogene tyrosine-protein kinase receptor Ret, Receptor-type tyrosine-protein kinase FLT3, Tyrosine-protein kinase ABL2, Vascular endothelial growth factor receptor 1, and Vascular endothelial growth factor receptor 3, Uniprot P04629, P07333, P07949, P10415, P16234, P17948, P35916, P36888, P42684, and Q08345
DOI: 10.7270/q2rn3cmr
title: BindingDB Entry 50013683: 2-((1-Phenyl-1H-1,2,3-triazol-4-yl)methyl)-2-azabicyclo[3.2.1]octan-3-one derivatives: Simplification and modification of aconitine scaffold for the discovery of novel anticancer agents.

description: Small molecule binding data for protein Heat shock protein HSP 90-alpha, Uniprot P07900
DOI: 10.7270/q2rn3cn6
title: BindingDB Entry 50013957: Promising anti-SARS-CoV-2 drugs by effective dual targeting against the viral and host proteases.

description: Small molecule binding data for protein Furin and Replicase polyprotein 1ab, Uniprot P09958 and P0DTD1
DOI: 10.7270/q2rn3cpn
title: BindingDB Entry 50014313: Discovery of novel trimethoxyphenylbenzo[d]oxazoles as dual tubulin/PDE4 inhibitors capable of inducing apoptosis at G2/M phase arrest in glioma and lung cancer cells.

description: Small molecule binding data for protein cAMP-specific 3',5'-cyclic phosphodiesterase 4C, Uniprot Q08493
DOI: 10.7270/q2rr2286
title: BindingDB Entry 9249: Selective inhibitors of protein arginine methyltransferase 5 (PRMT5)

description: Small molecule binding data for protein Protein arginine N-methyltransferase 5, Uniprot O14744
DOI: 10.7270/q2rr229n
title: BindingDB Entry 9636: Sulfonamide compound or salt thereof

description: Small molecule binding data for protein Muscarinic acetylcholine receptor M1/M2, Uniprot P08172 and P11229
DOI: 10.7270/q2rr22b3
title: BindingDB Entry 9845: 1,3,4-thiadiazole compounds and their use in treating cancer

description: Small molecule binding data for protein Glutaminase kidney isoform, mitochondrial [63-669], Uniprot O94925
DOI: 10.7270/q2rr22cj
title: BindingDB Entry 10023: Substituted 6-azabenzimidazole compounds

description: Small molecule binding data for protein Mitogen-activated protein kinase kinase kinase kinase 1, Uniprot Q92918
DOI: 10.7270/q2rr22d0
title: BindingDB Entry 10232: Tailored cyclodepsipeptides as potent non-covalent serine protease inhibitors

description: Small molecule binding data for protein Chymotrypsinogen B, Neutrophil elastase, Serine protease 1, Serine protease HTRA1 [158-480], Serine protease HTRA2, mitochondrial, and Serine protease HTRA3 [111-436], Uniprot O43464, P00760, P08246, P17538, P83110, and Q92743
DOI: 10.7270/q2rr22ff
title: BindingDB Entry 10619: Heterocyclic compounds as immunomodulators

description: Small molecule binding data for protein Programmed cell death 1 ligand 1 [19-238]/protein 1 [25-167], Uniprot Q15116 and Q9NZQ7
DOI: 10.7270/q2rr22gw
title: BindingDB Entry 50006761: Design of Small Molecule Autophagy Modulators: A Promising Druggable Strategy.

description: Small molecule binding data for protein 5'-AMP-activated protein kinase catalytic subunit alpha-1/subunit beta-1/subunit gamma-1, Cysteine protease ATG4B, DNA-dependent protein kinase catalytic subunit, Phosphatidylinositol 3-kinase catalytic subunit type 3, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, Rapamycin-insensitive companion of mTOR/Serine/threonine-protein kinase mTOR/Target of rapamycin complex 2 subunit MAPKAP1/Target of rapamycin complex subunit LST8, Serine-protein kinase ATM, Serine/threonine-protein kinase ATR, Serine/threonine-protein kinase ULK1, Serine/threonine-protein kinase ULK2, Serine/threonine-protein kinase mTOR, Target of rapamycin complex 2 subunit MAPKAP1, and Target of rapamycin complex subunit LST8, Uniprot O00329, O75385, P42336, P42338, P42345, P48736, P54619, P78527, Q13131, Q13315, Q13535, Q6R327, Q8IYT8, Q8NEB9, Q9BPZ7, Q9BVC4, Q9Y478, and Q9Y4P1
DOI: 10.7270/q2rr22hb
title: BindingDB Entry 50007352: Novel Bis-heteroaryl Derivatives To Modulate Protein Aggregation for the Treatment of Neurodegenerative Diseases.

description: Small molecule binding data for protein Alpha-synuclein, Uniprot P37840
DOI: 10.7270/q2rr22js
title: BindingDB Entry 50007690: Implementation of the CYP Index for the Design of Selective Tryptophan-2,3-dioxygenase Inhibitors.

description: Small molecule binding data for protein Cytochrome P450 3A4, Indoleamine 2,3-dioxygenase 1, and Tryptophan 2,3-dioxygenase, Uniprot P08684, P14902, and P48775
DOI: 10.7270/q2rr22k7
title: BindingDB Entry 50007966: Plasmepsin Inhibitors in Antimalarial Drug Discovery: Medicinal Chemistry and Target Validation (2000 to Present).

description: Small molecule binding data for protein Cathepsin D, Cathepsin E, Plasmepsin I, Plasmepsin II, Plasmepsin IV [1-448], and Plasmepsin V, Uniprot P07339, P14091, P39898, P46925, Q8I6Z5, and Q8IM16
DOI: 10.7270/q2rr22mp
title: BindingDB Entry 50008297: Exploiting the Tolerant Region I of the Non-Nucleoside Reverse Transcriptase Inhibitor (NNRTI) Binding Pocket: Discovery of Potent Diarylpyrimidine-Typed HIV-1 NNRTIs against Wild-Type and E138K Mutant Virus with Significantly Improved Water Solubility and Favorable Safety Profiles.

description: Small molecule binding data for protein Cytochrome P450 2C19, Cytochrome P450 2C9, Cytochrome P450 2D6, Cytochrome P450 3A4, and Reverse transcriptase, Uniprot P08684, P10635, P11712, P33261, and Q9WKE8
DOI: 10.7270/q2rr22n4
title: BindingDB Entry 50008581: Discovery of Potent Irreversible Pan-Fibroblast Growth Factor Receptor (FGFR) Inhibitors.

description: Small molecule binding data for protein ALK tyrosine kinase receptor, Ephrin type-A receptor 2, Epidermal growth factor receptor, Fibroblast growth factor receptor 1, Fibroblast growth factor receptor 2, Fibroblast growth factor receptor 3, Fibroblast growth factor receptor 4, Hepatocyte growth factor receptor, Insulin-like growth factor 1 receptor, Platelet-derived growth factor receptor alpha, Platelet-derived growth factor receptor beta, Proto-oncogene tyrosine-protein kinase Src, Receptor tyrosine-protein kinase erbB-2, Receptor tyrosine-protein kinase erbB-4, Tyrosine-protein kinase ABL1, Tyrosine-protein kinase BTK, Vascular endothelial growth factor receptor 1, and Vascular endothelial growth factor receptor 2, Uniprot P00519, P00533, P04626, P08069, P08581, P09619, P11362, P12931, P16234, P17948, P21802, P22455, P22607, P29317, P35968, Q06187, Q15303, and Q9UM73
DOI: 10.7270/q2rr22pk
title: BindingDB Entry 50008948: Identification of highly potent and selective MMP2 inhibitors addressing the S1' subsite with d-proline-based compounds.

description: Small molecule binding data for protein 72 kDa type IV collagenase and Matrix metalloproteinase-9, Uniprot P08253 and P14780
DOI: 10.7270/q2rr22q1
title: BindingDB Entry 50009560: Discovery of 2-substituted-N-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)-1,2,3,4-tetrahydroisoquinoline-6-carboxamide as potent and selective protein arginine methyltransferases 5 inhibitors: Design, synthesis and biological evaluation.

description: Small molecule binding data for protein Histone-arginine methyltransferase CARM1, Methylosome protein 50/Protein arginine N-methyltransferase 5, Protein arginine N-methyltransferase 1, Protein arginine N-methyltransferase 3, Protein arginine N-methyltransferase 6, Protein arginine N-methyltransferase 7, and Protein arginine N-methyltransferase 8, Uniprot O14744, O60678, Q86X55, Q96LA8, Q99873, Q9BQA1, Q9NR22, and Q9NVM4
DOI: 10.7270/q2rr22rg
title: BindingDB Entry 50010162: Discovery of BR102375, a new class of non-TZD PPARγ full agonist for the treatment of type 2 diabetes.

description: Small molecule binding data for protein Peroxisome proliferator-activated receptor gamma, Uniprot P37231
DOI: 10.7270/q2rr22sx
title: BindingDB Entry 50010750: Preclinical Lead Optimization of a 1,2,4-Triazole Based Tankyrase Inhibitor.

description: Small molecule binding data for protein 1,3-beta-glucan synthase component GSC2, Cytochrome P450 3A4, Poly [ADP-ribose] polymerase 1, Poly [ADP-ribose] polymerase 2, Poly [ADP-ribose] polymerase tankyrase-1/tankyrase-2, Poly [ADP-ribose] polymerase tankyrase-2, Protein mono-ADP-ribosyltransferase PARP10, Protein mono-ADP-ribosyltransferase PARP12, Protein mono-ADP-ribosyltransferase PARP14, Protein mono-ADP-ribosyltransferase PARP15, Protein mono-ADP-ribosyltransferase PARP3, and Protein mono-ADP-ribosyltransferase PARP4, Uniprot O95271, P08684, P09874, P40989, Q460N3, Q460N5, Q53GL7, Q9H0J9, Q9H2K2, Q9UGN5, Q9UKK3, and Q9Y6F1
DOI: 10.7270/q2rr22tc
title: BindingDB Entry 50011086: A panoramic review of IL-6: Structure, pathophysiological roles and inhibitors.

description: Small molecule binding data for protein Signal transducer and activator of transcription 3, Uniprot P40763
DOI: 10.7270/q2rr22vt
title: BindingDB Entry 50011377: TBA

description: Small molecule binding data for protein Acetyl-CoA carboxylase 1, Acetyl-CoA carboxylase 2, Bile salt export pump, Broad substrate specificity ATP-binding cassette transporter ABCG2, Cytochrome P450 1A2, Cytochrome P450 2B6, Cytochrome P450 2C19, Cytochrome P450 2C8, Cytochrome P450 2C9, Cytochrome P450 2D6, Cytochrome P450 3A4, Multidrug resistance-associated protein 1, Solute carrier family 22 member 2, Solute carrier family 22 member 6, Solute carrier family 22 member 8, Solute carrier organic anion transporter family member 1B1, Solute carrier organic anion transporter family member 1B3, UDP-glucuronosyltransferase 1-6, UDP-glucuronosyltransferase 1A4, UDP-glucuronosyltransferase 1A9, UDP-glucuronosyltransferase 2B15, and UDP-glucuronosyltransferase 2B7, Uniprot O00763, O15244, O60656, O95342, P05177, P08684, P10632, P10635, P11497, P11712, P16662, P19224, P20813, P22310, P33261, P33527, P54855, Q13085, Q4U2R8, Q8TCC7, Q9NPD5, Q9UNQ0, and Q9Y6L6
DOI: 10.7270/q2rr22w8
title: BindingDB Entry 50011710: Antiangiogenic Effect of (±)-Haloperidol Metabolite II Valproate Ester [(±)-MRJF22] in Human Microvascular Retinal Endothelial Cells.

description: Small molecule binding data for protein D(2) dopamine receptor, D(3) dopamine receptor, and Sigma non-opioid intracellular receptor 1, Uniprot P19020, P61169, and Q60492
DOI: 10.7270/q2rr22xq
title: BindingDB Entry 50012336: Pyrimido[1,2-b]indazole derivatives: Selective inhibitors of human monoamine oxidase B with neuroprotective activity.

description: Small molecule binding data for protein Amine oxidase [flavin-containing] A and Amine oxidase [flavin-containing] B, Uniprot P21397 and P27338
DOI: 10.7270/q2rr22z5
title: BindingDB Entry 50012961: A Chemical Probe for the Methyl Transferase PRMT5 with a Novel Binding Mode.

description: Small molecule binding data for protein Methylosome protein 50/Protein arginine N-methyltransferase 5 and Protein arginine N-methyltransferase 5, Uniprot O14744 and Q9BQA1
DOI: 10.7270/q2rr2301
title: BindingDB Entry 50013619: Discovery of a novel series of GPR119 agonists: Design, synthesis, and biological evaluation of N-(Piperidin-4-yl)-N-(trifluoromethyl)pyrimidin-4-amine derivatives.

description: Small molecule binding data for protein Glucose-dependent insulinotropic receptor, Uniprot Q7TQN8 and Q8TDV5
DOI: 10.7270/q2rr231g
title: BindingDB Entry 50014265: Functional Mixture-Based Positional Scan Identifies a Library of Antagonist Tetrapeptide Sequences (LAtTeS) with Nanomolar Potency for the Melanocortin-4 Receptor and Equipotent with the Endogenous AGRP(86-132) Antagonist.

description: Small molecule binding data for protein Melanocortin receptor 3, Melanocortin receptor 4, Melanocortin receptor 5, and Melanocyte-stimulating hormone receptor, Uniprot P33033, P41149, P56450, and Q01727
DOI: 10.7270/q2rr232x
title: BindingDB Entry 50014620: Design, synthesis, kinetic, molecular dynamics, and hypoglycemic effect characterization of new and potential selective benzimidazole derivatives as Protein Tyrosine Phosphatase 1B inhibitors.

description: Small molecule binding data for protein Tyrosine-protein phosphatase non-receptor type 1, Uniprot P18031
DOI: 10.7270/q2rv0rr1
title: BindingDB Entry 9040: Methods and compositions for cell-proliferation-related disorders

description: Small molecule binding data for protein Isocitrate dehydrogenase [NADP] cytoplasmic, Isocitrate dehydrogenase [NADP] cytoplasmic [R132H], L-lactate dehydrogenase A chain, and L-lactate dehydrogenase B chain, Uniprot O75874, P00338, and P07195
DOI: 10.7270/q2rv0rsg
title: BindingDB Entry 9427: Oxoisoquinoline derivatives

description: Small molecule binding data for protein Tyrosine-protein kinase BTK and Tyrosine-protein kinase BTK [C481S], Uniprot Q06187
DOI: 10.7270/q2rv0rtx
title: BindingDB Entry 9814: Substituted [1,2,4]triazolo[1,5-a]pyrazines as LSD1 inhibitors

description: Small molecule binding data for protein Lysine-specific histone demethylase 1A, Uniprot O60341
DOI: 10.7270/q2rv0rvc
title: BindingDB Entry 10201: Dihydropyrimidine compounds and uses thereof in medicine

description: Small molecule binding data for protein Large envelope protein, Uniprot P03138
DOI: 10.7270/q2rv0rwt
title: BindingDB Entry 10410: Inhibitors of phosphoglycerate dehydrogenase (PHGDH) and uses thereof

description: Small molecule binding data for protein D-3-phosphoglycerate dehydrogenase, Uniprot O43175
DOI: 10.7270/q2rv0rx8
title: BindingDB Entry 10588: 1-(2-(4-CYCLOPROPYL-1H-1,2,3-TRIAZOL-1-YL)ACETYL)-4-HYDROXYPYRROLIDINE-2-CARBOXA|MIDE DERIVATIVES AS VHL INHIBITORS FOR THE TREATMENT OF ANEMIA

description: Small molecule binding data for protein von Hippel-Lindau disease tumor suppressor, Uniprot P40337
DOI: 10.7270/q2rv0rzq
title: BindingDB Entry 10797: Kinase inhibitors

description: Small molecule binding data for protein Epithelial discoidin domain-containing receptor 1, Uniprot Q08345
DOI: 10.6084/m9.figshare.20377591
title: Temporal effect of phytoremediation on the bacterial community in petroleum-contaminated soil

description: Phytoremediation is a promising bio-technology where plants associated with microbes are employed to remediate sites co-contaminated with petroleum. With the in-depth study of plant restoration, it is necessary to explore the dynamic changes of microbial communities in petroleum-contaminated soil. This study investigated the effects of Ryegrass on bacterial community and diversity in petroleum contaminated soil. High-throughput sequencing technology was used to compare the bacterial communities in 14 groups samples at different repair stages. It was concluded that different responses were observed to promote or inhibit microbial reproduction. The most significant bacterial family were <i>Comamonadaceae</i>, <i>Nocardiaceae</i>, <i>Blastocatellaceae</i>, and <i>Cytophagacea</i>. <i>Comamonadaceae</i> showed the highest level of remediation in non-petroleum-contaminated soils at 90 days. However, <i>Blastocatellaceae</i> and <i>Cytophagaceae</i> exhibited high microbial contents in petroleum-contaminated soil at 0 and 40 days, respectively. In all samples, plants improved the remediation of petroleum-contaminated soil and the highest abundance of microbial communities were found after 90 days. These data indicate that not only rhizosphere secretions but also petroleum, will promote microbial growth. Moreover, the repair time has a vital effect on microbial community changes. This study supports the foundation to control soil pollution and highlight the periodic dynamic of microbial community diversity and structure.
DOI: 10.6084/m9.figshare.20377591.v1
title: Temporal effect of phytoremediation on the bacterial community in petroleum-contaminated soil

description: Phytoremediation is a promising bio-technology where plants associated with microbes are employed to remediate sites co-contaminated with petroleum. With the in-depth study of plant restoration, it is necessary to explore the dynamic changes of microbial communities in petroleum-contaminated soil. This study investigated the effects of Ryegrass on bacterial community and diversity in petroleum contaminated soil. High-throughput sequencing technology was used to compare the bacterial communities in 14 groups samples at different repair stages. It was concluded that different responses were observed to promote or inhibit microbial reproduction. The most significant bacterial family were <i>Comamonadaceae</i>, <i>Nocardiaceae</i>, <i>Blastocatellaceae</i>, and <i>Cytophagacea</i>. <i>Comamonadaceae</i> showed the highest level of remediation in non-petroleum-contaminated soils at 90 days. However, <i>Blastocatellaceae</i> and <i>Cytophagaceae</i> exhibited high microbial contents in petroleum-contaminated soil at 0 and 40 days, respectively. In all samples, plants improved the remediation of petroleum-contaminated soil and the highest abundance of microbial communities were found after 90 days. These data indicate that not only rhizosphere secretions but also petroleum, will promote microbial growth. Moreover, the repair time has a vital effect on microbial community changes. This study supports the foundation to control soil pollution and highlight the periodic dynamic of microbial community diversity and structure.
DOI: 10.7270/q2rv0s11
title: BindingDB Entry 50007647: Lead Optimization and Avoidance of Reactive Metabolite Leading to PCO371, a Potent, Selective, and Orally Available Human Parathyroid Hormone Receptor 1 (hPTHR1) Agonist.

description: Small molecule binding data for protein Parathyroid hormone/parathyroid hormone-related peptide receptor, Uniprot Q03431
DOI: 10.7270/q2rv0s2g
title: BindingDB Entry 50008252: Synthesis and exploration of 2-morpholino-4-phenylthiazol-5-yl acrylamide derivatives for their effects against carbonic anhydrase I, II, IX and XII isoforms as a non-sulfonamide class of inhibitors.

description: Small molecule binding data for protein Carbonic anhydrase 1, Carbonic anhydrase 12, Carbonic anhydrase 2, and Carbonic anhydrase 9, Uniprot O43570, P00915, P00918, and Q16790