DOI: 10.6084/m9.figshare.26990344
title: Additional file 1 of Simple model systems reveal conserved mechanisms of Alzheimer’s disease and related tauopathies

description: Additional file 1: Table S1. Genetic modifiers of AD identified in S. cerevisiae models. Table S2. Genetic modifiers of AD identified in C. elegans models. Table S3. Genetic modifiers of AD identified in Drosophila models. Table S4. Human orthologs of genetic modifiers identified in Aβ models. Human orthologs of S. cerevisiae genes were retrieved from the Saccharomyces Genome Database (SGD) YeastMine online tool. Orthologs of C. elegans genes were queried from the OrthoList2 online tool. Orthologs of Drosophila genes were obtained from FlyBase. AD genes identified from GWAS studies are highlighted in red. Table S5. Human orthologs of genetic modifiers identified in Tau models. Orthologs of S. cerevisiae genes were retrieved from the SGD YeastMine online tool. Orthologs of C. elegans genes were queried from the OrthoList2 online tool. Orthologs of Drosophila genes were obtained from FlyBase. AD genes identified from GWAS studies are highlighted in red. Table S6. Functional classes enrichment of Aβ modifiers identified in S. cerevisiae models analyzed using FunSpec. Gene list was queried to multiple yeast databases including GO Molecular Function, GO Biological Process, GO Cellular Component, MIPS Functional Classification, MIPS Phenotypes, MIPS Subcellular Localization, MIPS Protein Complexes using FunSpec. Table S7. Cellular pathways and processes linked to Tau modifiers. GO analysis of Tau modifiers identified in S. cerevisiae models was performed using FunSpec. Tau modifiers identified in C.elegansmodels were analyzed using the WormCat online tool. Tau modifiers identified in Drosophila models were grouped using the GLAD database. Table S8. Functional annotation and enrichment of Aβ modifiers identified in C. elegans models analyzed using WormCat. Gene list were input to WormCat using default settings for analyzation. Promoting genes indicated that deletion/reduction suppresses AD phenotypes and/or overexpression enhances AD phenotypes. Preventing genes indicated that deletion/reduction enhances AD phenotypes and/or overexpression suppresses AD phenotypes. Table S9. Functional annotation and enrichment of Tau modifiers identified in C. elegans models analyzed using WormCat. Gene lists were analyzed using WormCat. Promoting genes indicated that deletion/reduction suppresses AD phenotypes and/or overexpression enhances AD phenotypes. Preventing genes indicated that deletion/reduction enhances AD phenotypes and/or overexpression suppresses AD phenotypes. Table S10. Functional classes enrichment of Aβ modifiers identified in S. cerevisiae models analyzed using GO Slim Mapper. Gene list was queried to SGD Yeast GO-Slim database. Table S11. Functional annotation and enrichment of Aβ modifiers identified in C. elegans models analyzed using WormCat. Gene list were input to WormCat using default settings for analyzation. Promoting genes indicated that deletion/reduction suppresses AD phenotypes and/or overexpression enhances AD phenotypes. Preventing genes indicated that deletion/reduction enhances AD phenotypes and/or overexpression suppresses AD phenotypes. Table S12. Functional annotation and enrichment of Aβ modifiers identified in Drosophila models analyzed using GLAD. Gene list was analyzed using Find Group Membership function in the GLAD online tool [5, 6, 12, 19, 26, 28, 31, 33, 38, 39, 44, 47, 48, 52, 56, 57, 61, 68, 71, 73–75, 77, 79, 85, 90, 95–98, 100, 102, 111, 113, 115, 121, 131, 137, 145, 146, 152, 153, 155, 157, 161, 163, 164, 166, 170, 174, 175, 177–179, 181, 186, 188, 190, 192, 197, 199, 200, 202, 203, 211, 217–219, 223, 228, 230, 231, 237, 239, 241, 244, 246, 247, 253, 259, 262, 265, 272, 273, 280, 290, 292, 293, 295, 296, 298, 303, 306, 307, 310, 315, 316, 318, 319, 323, 326, 332–334, 336, 337].