cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.27254220.v1
title: Supplementary Material for: Post-asphyxial aftercare and management of neonates in low- and middle-income countries – A systematic evidence synthesis

description: Background: Effective post-resuscitation care is crucial for improving outcomes in neonates post-asphyxia. This review aims to provide a comprehensive overview of post-asphyxial aftercare strategies and forms part of a supplement describing an extensive synthesis of effective newborn interventions in low-and middle-income countries (LMICs). Evidence was generated by performing de-novo reviews, updates to reviews via systematic searches and re-analysis of studies conducted in LMICs from existing reviews. Summary: 61 trials recruiting 5046 term infants post-asphyxia were included across all intervention domains. Limited studies were available from LMICs related to fluid restriction, anti-seizure medications, and early interventions to improve developmental outcomes. Our re-analysis of whole-body cooling trials in LMICs found effects on neonatal mortality and mortality or neurological disability in infancy differed significantly based on the care center and type of cooling device used. Pharmacological therapies for neuroprotection evaluated in 27 trials in middle-income countries had varied effects in neonates with encephalopathy. Majority of the trials (60%) focused on magnesium sulfate therapy and showed significant improvements in short-term mortality and morbidities. Key Messages: The sample sizes of included trials were relatively small, and the certainty of evidence ranged from very low to moderate. Evidence on long-term survival and neurodevelopmental outcomes was limited. Further research on promising neuroprotective therapies and factors affecting their implementation in low-resource contexts is required. To reduce the high burden related to asphyxia in LMICs, this review underscores the need for a paradigm shift towards prevention, and strategies that emphasize improving antenatal and obstetric care.
DOI: 10.6084/m9.figshare.27191148.v1
title: Supplementary Material for: The development of an intradisciplinary staff training intervention on the optimal management of behavioural and psychological symptoms of dementia: A qualitative study

description: Introduction: Behavioural and psychological symptoms of dementia (BPSDs) are a group of highly prevalent symptoms in residents with a neurocognitive disorder (NCD), including agitation and depressive symptoms. Caregiving staff often mention knowledge and skills deficits regarding optimal BPSD management. While several staff trainings on BPSDs management exist internationally, their transferability to other clinical contexts is limited, owing to methodological challenges. Therefore, to address this implementation gap, there is a strong need for trainings based on high-quality research to strengthen existing evidence, ensure feasibility and reproducibility.
Methods: This qualitative study, part of a larger research project, occurred in 2022 on a long-term care (LTC) center unit and an alternate level of care (ALT) hospital unit located in the Province of Quebec, Canada. This study aimed to: 1) evaluate the needs and perceptions of staff caregivers regarding BPSD management, 2) identify the training content and modalities to prioritize according to experts, 3) develop an intradisciplinary training on BPSD management, and 4) pretest the preliminarily version of the training. Objectives one and two were evaluated using focus groups and objective four using individual cognitive interviews. Qualitative interview data was audio-recorded with participants’ consent, transcribed verbatim, and thematically content analyzed using an established method.
Results: Overall, thirteen caregivers participated in objective one (8 from the LTC unit, and 6 from the ALT unit). The main staff training need identified on each site was the management of resident’s aggressive behaviours. Staff verbalized a preference for a virtual training. Objective 2 involved a panel of eight experts. Experts recommended the use of an online training platform, and certain training models and indicators. Based on caregivers and experts’ input, five interactive online staff training capsules lasting from 20-25 minutes each and an algorithm guiding the evaluation and management of BPSDs were created. The training capsules and the algorithm were iteratively improved following cognitive interviews with 4 caregivers from the participating sites. 
Conclusion: An interactive virtual staff training on BPSD management was created based on staff and expert consultation. The next step in investigation will be to evaluate the feasibility and acceptability of the training.
DOI: 10.6084/m9.figshare.27254223
title: Supplementary Material for: Optical coherence tomography abnormalities as the presenting sign of an involuted sellar/suprasellar mass

description: Introduction: Pituitary adenomas are benign tumors that can lead to visual loss through compression of the optic chiasm. Patients with pituitary adenomas often present with visual field defects (commonly bitemporal hemianopia), but some may be asymptomatic. In such cases, abnormalities may only be detected through visual field testing or optical coherence tomography (OCT) of the ganglion cell-inner plexiform layer (GCIPL), may provide a more sensitive method for detecting such abnormalities. 
 
Case presentation: A 72-year-old man was incidentally found to have binasal OCT-GCIPL thinning during a routine eye examination. Visual acuity was 20/20 in both eyes. Pupils were equal and reactive without a relative afferent pupillary defect. His Humphrey 24-2 SITA-Fast visual field test results were normal. An MRI revealed a non-enhancing (cystic) sellar/suprasellar mass measuring 1.7 cm craniocaudal by 2.1 cm anteroposteriorly, without associated optic chiasm compression. The lesion was suspected to be either a cystic pituitary adenoma or a Rathke’s cleft cyst. Follow-up examination one year later showed all findings remained stable, including an unchanged visual acuity, visual fields, OCT-GCIPL and MRI.

Conclusion: The binasal thinning observed on OCT-GCIPL in this case, despite the absence of chiasmal compression on MRI, is suggestive of previous compression of the optic chiasm. This case highlights the potential for spontaneous regression of pituitary adenomas and underscores the importance of OCT-GCIPL as a vital tool for detecting optic chiasmal damage.
DOI: 10.6084/m9.figshare.27254223.v1
title: Supplementary Material for: Optical coherence tomography abnormalities as the presenting sign of an involuted sellar/suprasellar mass

description: Introduction: Pituitary adenomas are benign tumors that can lead to visual loss through compression of the optic chiasm. Patients with pituitary adenomas often present with visual field defects (commonly bitemporal hemianopia), but some may be asymptomatic. In such cases, abnormalities may only be detected through visual field testing or optical coherence tomography (OCT) of the ganglion cell-inner plexiform layer (GCIPL), may provide a more sensitive method for detecting such abnormalities. 
 
Case presentation: A 72-year-old man was incidentally found to have binasal OCT-GCIPL thinning during a routine eye examination. Visual acuity was 20/20 in both eyes. Pupils were equal and reactive without a relative afferent pupillary defect. His Humphrey 24-2 SITA-Fast visual field test results were normal. An MRI revealed a non-enhancing (cystic) sellar/suprasellar mass measuring 1.7 cm craniocaudal by 2.1 cm anteroposteriorly, without associated optic chiasm compression. The lesion was suspected to be either a cystic pituitary adenoma or a Rathke’s cleft cyst. Follow-up examination one year later showed all findings remained stable, including an unchanged visual acuity, visual fields, OCT-GCIPL and MRI.

Conclusion: The binasal thinning observed on OCT-GCIPL in this case, despite the absence of chiasmal compression on MRI, is suggestive of previous compression of the optic chiasm. This case highlights the potential for spontaneous regression of pituitary adenomas and underscores the importance of OCT-GCIPL as a vital tool for detecting optic chiasmal damage.
DOI: 10.6084/m9.figshare.27254226
title: Supplementary Material for: Colorectal Endoscopic Full-Thickness Resection: a Portuguese multicenter experience based on a retrospective cohort

description: Introduction: EFTR is a minimally invasive endoscopic technique that allows the resection of complex colorectal lesions, such as non-lifting, peri-appendicular, peri-diverticula, and subepithelial lesions. Published data suggests that EFTR has a technical success and R0 resection rates of 89 and 79%, respectively, and an adverse event rate of 12%. This study summarizes the EFTR experience in nine Portuguese centers with regard to its efficacy and safety.
Methods: This was a multicenter uncontrolled retrospective study, including 129 colorectal EFTRs between March 2017 to September 2023. The main outcomes were procedural and technical success, R0 resection, curative resection, adverse events, and recurrence rate.
Results: 129 EFTR procedures were conducted, with a technical success rate of 88.4% (114/129). Most lesions were in the right colon, with a median resection size of 25 [10-45] mm. R0 and curative resection rate were 75.9% (85/112) and 58.0% (65/112), respectively. Adverse events occurred in 13.2% (17/129) of patients, mostly due to immediate perforation, appendicitis, or delayed bleeding, needing surgery in 5.4% (7/129). Local recurrence rate occurred in 5.4% (5/92) of resections.
Conclusion: This real-life multicenter study highlights the utility of colorectal EFTR for management of complex and carefully chosen lesions, with an acceptable adverse events rate and need for surgery.
DOI: 10.6084/m9.figshare.27254226.v1
title: Supplementary Material for: Colorectal Endoscopic Full-Thickness Resection: a Portuguese multicenter experience based on a retrospective cohort

description: Introduction: EFTR is a minimally invasive endoscopic technique that allows the resection of complex colorectal lesions, such as non-lifting, peri-appendicular, peri-diverticula, and subepithelial lesions. Published data suggests that EFTR has a technical success and R0 resection rates of 89 and 79%, respectively, and an adverse event rate of 12%. This study summarizes the EFTR experience in nine Portuguese centers with regard to its efficacy and safety.
Methods: This was a multicenter uncontrolled retrospective study, including 129 colorectal EFTRs between March 2017 to September 2023. The main outcomes were procedural and technical success, R0 resection, curative resection, adverse events, and recurrence rate.
Results: 129 EFTR procedures were conducted, with a technical success rate of 88.4% (114/129). Most lesions were in the right colon, with a median resection size of 25 [10-45] mm. R0 and curative resection rate were 75.9% (85/112) and 58.0% (65/112), respectively. Adverse events occurred in 13.2% (17/129) of patients, mostly due to immediate perforation, appendicitis, or delayed bleeding, needing surgery in 5.4% (7/129). Local recurrence rate occurred in 5.4% (5/92) of resections.
Conclusion: This real-life multicenter study highlights the utility of colorectal EFTR for management of complex and carefully chosen lesions, with an acceptable adverse events rate and need for surgery.
DOI: 10.5281/zenodo.13948971
title: ФОРМИРОВАНИЕ ФИНАНСОВОЙ ГРАМОТНОСТИ СТУДЕНТОВ ВУЗА: МЕТОДЫ, ИНСТРУМЕНТЫ И ПРАКТИКИ ДЛЯ ПРЕПОДАВАТЕЛЕЙ
DOI: 10.5281/zenodo.13948972
title: ФОРМИРОВАНИЕ ФИНАНСОВОЙ ГРАМОТНОСТИ СТУДЕНТОВ ВУЗА: МЕТОДЫ, ИНСТРУМЕНТЫ И ПРАКТИКИ ДЛЯ ПРЕПОДАВАТЕЛЕЙ
DOI: 10.6084/m9.figshare.27094018
title: Supplementary Material for: A scoping review of fall-risk screening tools in the Emergency Department for future falls in older adults.

description: Background
Approximately one third of adults over the age of 65 experience falls annually, with half resulting in injury. Peak bodies have recommended the use of fall-risk screening tools in the emergency department (ED) to identify patients requiring in-depth assessment and potential fall-prevention intervention. This study aimed to examine the scope of published studies on fall-risk screening tools used in the ED, and evidence of associations between screening and future falls.
Summary
PubMed, Embase and CINAHL were searched for peer-reviewed journal articles published since 2012 that examined one or more screening tools to identify patient-level fall risk. Eligible studies described fall-risk tools applied in the ED. Data extracted included sample information, variables measured and statistical analysis.
Sixteen studies published since 2012 were included after full-text review. Fourteen unique screening tools were found. Eight tools were fall-risk screening tools, one tool was a functional screening tool, one tool was a frailty screening tool, two tools were rapid physical tests, one tool was a trauma triage tool, and one tool was a component of a health-related quality of life measure. Studies that evaluated prognostic performance (n = 11) generally reported sensitivity higher than specificity. Previous falls (n = 10) and high-risk medications (n = 6) were consistently associated with future falls. Augmentation with additional variables from the electronic medical record (EMR) improved screening tool prognostic performance in one study.
Key Messages
Current evidence on the association between the use of fall-risk screening tools in the ED for future falls consistently identifies previous falls and high-risk medications as associated with future falls. Comparison between tools is difficult due to different evaluation methods and different covariates measured. Augmentation of fall-risk screening using the EMR in the ED requires further investigation.
DOI: 10.6084/m9.figshare.27094018.v1
title: Supplementary Material for: A scoping review of fall-risk screening tools in the Emergency Department for future falls in older adults.

description: Background
Approximately one third of adults over the age of 65 experience falls annually, with half resulting in injury. Peak bodies have recommended the use of fall-risk screening tools in the emergency department (ED) to identify patients requiring in-depth assessment and potential fall-prevention intervention. This study aimed to examine the scope of published studies on fall-risk screening tools used in the ED, and evidence of associations between screening and future falls.
Summary
PubMed, Embase and CINAHL were searched for peer-reviewed journal articles published since 2012 that examined one or more screening tools to identify patient-level fall risk. Eligible studies described fall-risk tools applied in the ED. Data extracted included sample information, variables measured and statistical analysis.
Sixteen studies published since 2012 were included after full-text review. Fourteen unique screening tools were found. Eight tools were fall-risk screening tools, one tool was a functional screening tool, one tool was a frailty screening tool, two tools were rapid physical tests, one tool was a trauma triage tool, and one tool was a component of a health-related quality of life measure. Studies that evaluated prognostic performance (n = 11) generally reported sensitivity higher than specificity. Previous falls (n = 10) and high-risk medications (n = 6) were consistently associated with future falls. Augmentation with additional variables from the electronic medical record (EMR) improved screening tool prognostic performance in one study.
Key Messages
Current evidence on the association between the use of fall-risk screening tools in the ED for future falls consistently identifies previous falls and high-risk medications as associated with future falls. Comparison between tools is difficult due to different evaluation methods and different covariates measured. Augmentation of fall-risk screening using the EMR in the ED requires further investigation.
DOI: 10.6084/m9.figshare.27087673
title: Supplementary Material for: Vitamin A deficiency disturbs Ret expression and induces urinary tract developmental abnormalities in mice

description: Abstract
Introduction: Moderate vitamin A levels during pregnancy are strongly related to normal embryonic development in both animal models and population studies. Abnormal development of urinary tract system is linked to either an excess or a shortage of vitamin A. The relationships among maternal vitamin A deficiency prior to conception, moderate vitamin A supplementation during pregnancy, and abnormal urinary system development in offspring are unclear. 
Methods: By creating preconception and preconception + pregnancy vitamin A insufficiency mouse models, we investigated whether moderate vitamin A treatment during pregnancy may reduce the prevalence of CAKUT and increase distant vitamin A levels in offspring, as well as any potential pathways involved. 
Results: We effectively established a prepregnancy vitamin A-deficient mouse model by providing a particular diet with or without vitamin A for four weeks. The offspring of the hypovitaminosis A model group presented a greater proportion of neonatal urinary tract developmental malformations. Abnormalities in ureteral bud emergence and key molecules during renal development, such as p-Plcγ and Ret, may be the primary causes of offspring development of CAKUT as a result of mothers’ hypovitaminosis A. Normal vitamin A diets, on the other hand, may help mitigate the teratogenic consequences of prepregnancy hypovitaminosis A, as well as defects produced by ureteral budding and major molecular changes.
Conclusion: In contrast, the administration of normal vitamin A feeds during pregnancy may ameliorate the teratogenic effects of prepregnancy hypovitaminosis A to a certain extent and may also ameliorate the abnormalities associated with ureteral budding and key molecular changes.
DOI: 10.6084/m9.figshare.27087673.v1
title: Supplementary Material for: Vitamin A deficiency disturbs Ret expression and induces urinary tract developmental abnormalities in mice

description: Abstract
Introduction: Moderate vitamin A levels during pregnancy are strongly related to normal embryonic development in both animal models and population studies. Abnormal development of urinary tract system is linked to either an excess or a shortage of vitamin A. The relationships among maternal vitamin A deficiency prior to conception, moderate vitamin A supplementation during pregnancy, and abnormal urinary system development in offspring are unclear. 
Methods: By creating preconception and preconception + pregnancy vitamin A insufficiency mouse models, we investigated whether moderate vitamin A treatment during pregnancy may reduce the prevalence of CAKUT and increase distant vitamin A levels in offspring, as well as any potential pathways involved. 
Results: We effectively established a prepregnancy vitamin A-deficient mouse model by providing a particular diet with or without vitamin A for four weeks. The offspring of the hypovitaminosis A model group presented a greater proportion of neonatal urinary tract developmental malformations. Abnormalities in ureteral bud emergence and key molecules during renal development, such as p-Plcγ and Ret, may be the primary causes of offspring development of CAKUT as a result of mothers’ hypovitaminosis A. Normal vitamin A diets, on the other hand, may help mitigate the teratogenic consequences of prepregnancy hypovitaminosis A, as well as defects produced by ureteral budding and major molecular changes.
Conclusion: In contrast, the administration of normal vitamin A feeds during pregnancy may ameliorate the teratogenic effects of prepregnancy hypovitaminosis A to a certain extent and may also ameliorate the abnormalities associated with ureteral budding and key molecular changes.
DOI: 10.6084/m9.figshare.27083074
title: Supplementary Material for: Immediate-Release vs. Extended-Release Tacrolimus: Comparing Blood Pressure Control in Kidney Transplant Recipients – A Retrospective Cohort Study

description: Background
Hypertension (HTN) is a common side effect of Tacrolimus (Tac), the first-line anti-rejection medication for kidney transplant recipients. The impact of immediate-release tacrolimus (Tac IR) dosed twice daily versus extended-release tacrolimus (Tac ER) dosed once daily on long-term blood pressure control in kidney transplant recipients remains understudied. This study aims to compare the use of Tac IR versus Tac ER in kidney transplant recipients and evaluate the effects of the different formulations on systolic blood pressure (SBP), diastolic blood pressure (DBP), and HTN crisis.
Methods
This retrospective cohort study at a single institution collected baseline characteristics, time-varying exposure to Tac IR vs Tac ER, SBP, DBP, HTN crisis, and confounders at each post-transplant visit. A marginal structural linear mixed-effects model was employed to analyze the longitudinal blood pressure control in kidney transplant recipients receiving Tac IR and Tac ER.
Results
The final analysis included 654 patients, with mean ages of 52.0 years for Tac IR and 50.3 years for Tac ER. Males constituted 56.7% in Tac IR and 55.0% in Tac ER. Notably, the Black population had 2.44 times higher odds of receiving Tac ER after adjusting for the rest of the baseline characteristics. No difference was found between longitudinal SBP (p=0.386, 95% CI: -1.00, 2.57) or DBP (p=0.797, 95% CI: -1.38, 1.06). 
Conclusion
Our study indicates that post-transplant patients taking Tac ER exhibit no difference in chronic SBP and DBP controls compared to Tac IR.
DOI: 10.6084/m9.figshare.27083074.v1
title: Supplementary Material for: Immediate-Release vs. Extended-Release Tacrolimus: Comparing Blood Pressure Control in Kidney Transplant Recipients – A Retrospective Cohort Study

description: Background
Hypertension (HTN) is a common side effect of Tacrolimus (Tac), the first-line anti-rejection medication for kidney transplant recipients. The impact of immediate-release tacrolimus (Tac IR) dosed twice daily versus extended-release tacrolimus (Tac ER) dosed once daily on long-term blood pressure control in kidney transplant recipients remains understudied. This study aims to compare the use of Tac IR versus Tac ER in kidney transplant recipients and evaluate the effects of the different formulations on systolic blood pressure (SBP), diastolic blood pressure (DBP), and HTN crisis.
Methods
This retrospective cohort study at a single institution collected baseline characteristics, time-varying exposure to Tac IR vs Tac ER, SBP, DBP, HTN crisis, and confounders at each post-transplant visit. A marginal structural linear mixed-effects model was employed to analyze the longitudinal blood pressure control in kidney transplant recipients receiving Tac IR and Tac ER.
Results
The final analysis included 654 patients, with mean ages of 52.0 years for Tac IR and 50.3 years for Tac ER. Males constituted 56.7% in Tac IR and 55.0% in Tac ER. Notably, the Black population had 2.44 times higher odds of receiving Tac ER after adjusting for the rest of the baseline characteristics. No difference was found between longitudinal SBP (p=0.386, 95% CI: -1.00, 2.57) or DBP (p=0.797, 95% CI: -1.38, 1.06). 
Conclusion
Our study indicates that post-transplant patients taking Tac ER exhibit no difference in chronic SBP and DBP controls compared to Tac IR.
DOI: 10.5281/zenodo.13948976
title: SIGIRLAR ORGANIZMIDA MODDALAR ALMASHINUVI JARAYONLARIDA UGLEVODLARNI ROLI
DOI: 10.5281/zenodo.13948977
title: SIGIRLAR ORGANIZMIDA MODDALAR ALMASHINUVI JARAYONLARIDA UGLEVODLARNI ROLI