cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.11604369.v1
title: Supplementary Material for: Finasteride and Suicide: A Postmarketing Case Series

description: <b><i>Background:</i></b> In 2011, depression was added to the product labeling of finasteride in the USA. The US Food and Drug Administration’s Adverse Event Reporting System database contains at least 36 death cases for finasteride. The aim of this study is to characterize the clinical histories and symptoms reported by a series of 6 suicide victims who took finasteride for treatment of androgenic alopecia. <b><i>Methods:</i></b> Medical records and autopsy reports were provided by family members of the cases. Relevant information was extracted according to guidelines for submitting adverse event reports. <b><i>Results:</i></b> An important pattern of symptoms was common among all cases who committed suicide in the setting of finasteride use – insomnia and persistent sexual dysfunction after medication discontinuation. Insomnia and fatigue/tiredness were some of the most debilitating symptoms. Apart from 1 case who had hyperlipidemia, there was no documentation of concomitant medication use with finasteride or any baseline medical or psychiatric diagnoses prior to starting finasteride. The findings of this postmarketing series may not be generalizable to the population of men who committed suicide in the setting of finasteride use due to small sample size and bias. Associations between medication use and symptoms cannot prove causality. <b><i>Conclusion:</i></b> Men under the age of 40 who use finasteride for alopecia are at risk for suicide if they develop persistent sexual adverse effects and insomnia. Further research is needed to establish whether finasteride has a causal relationship to suicide.
DOI: 10.6084/m9.figshare.11604336
title: Supplementary Material for: Analysis of Characteristics and Trends in Treatment Response of Hidradenitis Suppurativa Patients: A Southern US Cohort Study

description: <b><i>Background:</i></b> Hidradenitis suppurativa (HS) is a chronic inflammatory skin condition that has a substantial impact on patients’ quality of life. As the exact pathogenesis remains unclear, treatment is complex and not yet standardized. <b><i>Objectives:</i></b> The aim of this study was to describe patient characteristics and to broadly examine trends in treatment response of various therapeutic strategies in patients with HS in a single academic referral center in the southern USA. <b><i>Methods:</i></b> A retrospective chart review was conducted of a cohort of HS patients seen in a faculty general dermatology practice with academic affiliation to Baylor University Medical Center in Dallas, TX, between February 2015 and February 2018. Patient demographics, clinical features, prescribed treatments, and response to treatment were analyzed using the Pearson χ<sup>2</sup> test or Fisher exact test, and by the Mann-Whitney U test for categorical and continuous variables, respectively. <b><i>Results:</i></b> A total of 149 patients (113 females, 36 males) were included. Hurley stages I, II, and III were diagnosed in 29.6, 36.5, and 33.9% of patients, respectively. 44.2% of patients had a positive family history of HS, 39.5% of patients were current or former smokers, and 52.8% reported alcohol use. 80.9% of patients were overweight or obese (BMI ≥25), compared to 68.5% in Texas in 2016 (<i>p</i> = 0.0012). The most frequently prescribed treatments were oral antibiotic therapy (83.9%), topical antibiotic therapy (74.5%), metabolic medications such as metformin/zinc (67.1%), intralesional Kenalog (63.1%), and biologic therapies (tumor necrosis factor-α inhibitors; TNF-α inhibitors; 49%). In examining the response rate, patients with disease localized to the buttocks had significantly higher response rates (60.4 vs. 25%, <i>p</i> = 0.043) and approached statistical significance in responders versus nonresponders in treatment with biologics (<i>p</i> = 0.0632) when compared against all other treatments. <b><i>Conclusions:</i></b> HS is a complex inflammatory skin condition associated with obesity and smoking. In this cohort, the most frequently prescribed therapies were oral and topical antibiotics. However, the use of biologic agents (TNF-α inhibitors) appears to be associated with the most significant treatment response. <b><i>Key Points:</i></b> This is the first study to evaluate trends in treatment response of various therapeutic strategies in HS patients at an academic referral center in Dallas, TX, a unique geographic region of the southern USA. Biologic therapy (TNF-α inhibitor) appears to be associated with the most significant treatment response.
DOI: 10.6084/m9.figshare.11604324
title: Dataset.csv

description: The labelled address dataset for Chinese address model classification.
DOI: 10.6084/m9.figshare.11604336.v1
title: Supplementary Material for: Analysis of Characteristics and Trends in Treatment Response of Hidradenitis Suppurativa Patients: A Southern US Cohort Study

description: <b><i>Background:</i></b> Hidradenitis suppurativa (HS) is a chronic inflammatory skin condition that has a substantial impact on patients’ quality of life. As the exact pathogenesis remains unclear, treatment is complex and not yet standardized. <b><i>Objectives:</i></b> The aim of this study was to describe patient characteristics and to broadly examine trends in treatment response of various therapeutic strategies in patients with HS in a single academic referral center in the southern USA. <b><i>Methods:</i></b> A retrospective chart review was conducted of a cohort of HS patients seen in a faculty general dermatology practice with academic affiliation to Baylor University Medical Center in Dallas, TX, between February 2015 and February 2018. Patient demographics, clinical features, prescribed treatments, and response to treatment were analyzed using the Pearson χ<sup>2</sup> test or Fisher exact test, and by the Mann-Whitney U test for categorical and continuous variables, respectively. <b><i>Results:</i></b> A total of 149 patients (113 females, 36 males) were included. Hurley stages I, II, and III were diagnosed in 29.6, 36.5, and 33.9% of patients, respectively. 44.2% of patients had a positive family history of HS, 39.5% of patients were current or former smokers, and 52.8% reported alcohol use. 80.9% of patients were overweight or obese (BMI ≥25), compared to 68.5% in Texas in 2016 (<i>p</i> = 0.0012). The most frequently prescribed treatments were oral antibiotic therapy (83.9%), topical antibiotic therapy (74.5%), metabolic medications such as metformin/zinc (67.1%), intralesional Kenalog (63.1%), and biologic therapies (tumor necrosis factor-α inhibitors; TNF-α inhibitors; 49%). In examining the response rate, patients with disease localized to the buttocks had significantly higher response rates (60.4 vs. 25%, <i>p</i> = 0.043) and approached statistical significance in responders versus nonresponders in treatment with biologics (<i>p</i> = 0.0632) when compared against all other treatments. <b><i>Conclusions:</i></b> HS is a complex inflammatory skin condition associated with obesity and smoking. In this cohort, the most frequently prescribed therapies were oral and topical antibiotics. However, the use of biologic agents (TNF-α inhibitors) appears to be associated with the most significant treatment response. <b><i>Key Points:</i></b> This is the first study to evaluate trends in treatment response of various therapeutic strategies in HS patients at an academic referral center in Dallas, TX, a unique geographic region of the southern USA. Biologic therapy (TNF-α inhibitor) appears to be associated with the most significant treatment response.
DOI: 10.6084/m9.figshare.11604324.v1
title: Dataset.csv

description: The labelled address dataset for Chinese address model classification.
DOI: 10.6084/m9.figshare.11604312
title: Sulawesi tree species abundance by plot matrix

description: Species abundance per plot matrix for 10 sites on ultramafic, mafic, sand and limestone soils.
DOI: 10.6084/m9.figshare.11604267
title: Surveys of grass cover and the scat of an endangered lizard (Gambelia sila) in Panoche Hills, California.

description: Surveys of shrubs were conducted at Panoche Hills Management Area, in California USA. The shrubs were surveyed using detection dogs to find scat of the blunt-nosed leopard lizard (Gambelia sila). In May 2013, we surveyed 700 shrubs, measured the dimensions, and recorded the GPS coordinates. In May 2014, we surveyed a subset of the 700 shrubs and included survey of open areas adjacent to the shrubs. In both years, we also collected residual dry matter (RDM) collected in September of the remaining residual thatch prior to fall rains. The RDM was collected along a systematic grid throughout the study region and encompassing all of the 700 surveyed shrubs. For more information about methods and study site, see published study:Filazzola, A., Westphal, M., Powers, M., Liczner, A. R., Woollett, D. A. S., Johnson, B., & Lortie, C. J. (2017). Non-trophic interactions in deserts: Facilitation, interference, and an endangered lizard species. <i>Basic and applied ecology</i>, <i>20</i>, 51-61.
DOI: 10.6084/m9.figshare.11604222
title: Data.zip

description: The data is the temperature change and deformation of the steel tube.
DOI: 10.6084/m9.figshare.11604222.v1
title: Data.zip

description: The data is the temperature change and deformation of the steel tube.
DOI: 10.6084/m9.figshare.11604192
title: Labels for Hurricane Florence (2018) Emergency Response Imagery from NOAA

description: This csv file contains labels for &gt;300 images obtained by the US National Oceanic and Atmospheric Administration (NOAA) in response to Hurricane Florence. Images were taken on Sept. 17th 2018, and are downloadable from the NOAA Emergency Response Imagery website (see references below). All labeled images are from the ‘September 17 A 2018’ file. The 'image_id' column in the csv corresponds to the name of the JPEGs.<br>Images were tagged by the first 8 authors of this dataset. Each image was tagged 2-5 times by different people. Authorship order was derived by the number of images tagged. Image tagging was done using a bespoke dashboard built by five authors (author 9 through 13), under the supervision of the final author (author 14). <br> There are 10 columns in the csv:<br> 1) image_id — reports the name of the corresponding NOAA JPEG. <br>2) ocean - 1 if the image is all water. <br>3) development - 1 if the image has human development. <br>4) washover - 1 if a washover deposit can be seen in the image. <br>5) impact - based on the Sallenger (2000) ‘Storm Impact Scale for barrier islands’ (see references below). 0 is no visible impact, 1 for swash, 2 for collision, 3 for overwash, 4 for inundation. <br>6) terrain_inland - 1 if the image is an inland scene. <br>7) terrain_marsh - 1 if the image is a marsh scene. <br>8) terrain_river - 1 if image is of riverine scene. <br>9) terrrain_sandy_coastline - 1 if image is a sandy coastline scene. <br>10) terrain_undefined - 1 if no terrain type applies. <br> multiple terrain types can be specified for a given image — i.e., there can be multiple '1's for a given image in columns 6-10. <br>
DOI: 10.6084/m9.figshare.11604195
title: Supplementary Material for: SERINC5 Is an Unconventional HIV Restriction Factor That Is Upregulated during Myeloid Cell Differentiation

description: Classical antiviral restriction factors promote cellular immunity by their ability to interfere with virus replication and induction of their expression by proinflammatory cytokines such as interferons. The serine incorporator proteins SERINC3 and SERINC5 potently reduce the infectivity of HIV-1 particles when overexpressed, and RNA interference or knockout approaches in T cells have indicated antiviral activity also of the endogenous proteins. Due to lack of reagents for detection of endogenous SERINC proteins, it is still unclear whether SERINC3/5 are expressed to functionally relevant levels in different primary target cells of HIV infection and how the expression levels of these innate immunity factors are regulated. In the current study, analysis of <i>SERINC3/5</i> mRNA steady-state levels in primary lymphoid and monocyte-derived cells revealed selective induction of their expression upon differentiation of myeloid cells. Contrary to classical antiviral restriction factors, various antiviral α-interferon subtypes and proinflammatory interleukins had no effect on <i>SERINC</i> levels, which were also not dysregulated in CD4+ T cells and monocytes isolated from patients with chronic HIV-1 infection. Notably, HIV-1 particles produced by terminally differentiated monocyte-derived macrophages with high <i>SERINC5</i> expression, but not by low-expressing monocytes, showed a Nef-dependent infectivity defect. Overall, these findings suggest endogenous expression of SERINC5 to antivirally active levels in macrophages. Our results classify SERINC5 as an unconventional HIV-1 restriction factor whose expression is specifically induced upon differentiation of cells towards the myeloid lineage.
DOI: 10.6084/m9.figshare.11604135
title: Supplementary Material for: A 2018 European Thyroid Association Survey on the Use of Selenium Supplementation in Hashimoto’s Thyroiditis

description: <b><i>Objective:</i></b> To investigate clinical practice regarding the use of selenium supplementation in patients with Hashimoto’s thyroiditis (HT) among members of the European Thyroid Association (ETA). <b><i>Methods:</i></b> ETA members were invited to participate in an online survey investigating the use of selenium supplementation across the spectrum of benign thyroid diseases. Of 872 invited members, 242 (28%) completed the survey. After exclusion of basic scientists and non-European members, survey data from 212 respondents were eligible for further analyses. Responses from 65 (31%) individuals who did not at all recommend selenium, or only considered its use in the setting of a clinical trial, were not included in the final analysis of survey data from 147 respondents. ­<b><i>Results:</i></b> While only a minority of respondents (29 of 147, 20%) stated that the available evidence warrants the use of Se in patients with HT, a statistically significant majority (95 of 147; 65%, <i>p</i> &lt; 0.001) used Se occasionally or routinely. Se was predominantly recommended for patients with HT not receiving LT4 (102 of 147; 69%) to reduce circulating thyroid autoantibody levels. Very few respondents routinely recommended Se to pregnant patients with HT. <b><i>Conclusions:</i></b> A minority of responding ETA members stated that the available evidence warrants the use of Se in HT, but a majority recommended it to some extent, especially to patients not yet receiving LT4. This is questionable, and selenium is not recommended to patients with HT according to current ETA guidelines. Ongoing and future trials may lead to the reversal of current medical practice.
DOI: 10.6084/m9.figshare.11604111
title: Mean annual variables US catchments

description: This excel file contains the mean annual variables used in the manuscript: <b>An aridity index-based formulation of streamflow component, </b>submitted to Water Resources Research.<br>Variables:<br><br>Precipitation (P)Potential Evapotranspiration (PET)Aridity Index (phi)Direct Runoff (Qd)Wetting (W)Baseflow (Qb)Streamflow (Q)HISTORY
DOI: 10.6084/m9.figshare.11604111.v1
title: Mean annual variables US catchments

description: This excel file contains the mean annual variables used in the manuscript: <b>An aridity index-based formulation of streamflow component, </b>submitted to Water Resources Research.<br>Variables:<br><br>Precipitation (P)Aridity Index (phi)Direct Runoff (Qd)Wetting (W)Baseflow (Qb)Streamflow (Q)HISTORY
DOI: 10.6084/m9.figshare.11604063
title: Woodlice cell size data

description: Data on cell size and metabolic rate of common rough woodlice isopods.<br><br>
DOI: 10.6084/m9.figshare.11604009
title: Spouses’ perceptions of and attitudes toward female menopause: a mixed-methods systematic review

description: <b>Objective:</b> Menopausal women experience physical and psychological discomfort, which may be affected by their spouses’ perceptions of and attitudes toward menopause. The purpose of this review is to summarize men’s perceptions of and attitudes toward female menopause in different cultural contexts. <b>Method:</b> A sequential integrated design method was used in this mixed-methods systematic review. PubMed, Web of Science, PsycINFO, Cochrane, Embase, China National Knowledge Infrastructure, and the Wanfang database were searched. Studies on spousal perceptions of and attitudes toward female menopause were included in the analysis. <b>Results:</b> A total of 12 articles met the inclusion criteria. Men have little knowledge of menopause and health-care status. Men have different attitudes toward wives’ changes during menopause. A large proportion of them cannot cope with these changes, possibly due to poor knowledge about menopause; aging and disease; psychological changes; religious and other internal factors; and external factors, including family life, work stress, and wives’ menopausal symptoms. In addition, spouses’ perceptions of and attitudes toward menopause may affect women’s menopausal symptoms, attitudes toward menopause, and marriage relationships. <b>Conclusion:</b> Although there was little evidence, it seems that male spouses’ perceptions of and attitudes toward female menopause are important factors affecting menopausal women’s quality of life.
DOI: 10.6084/m9.figshare.11604009.v1
title: Spouses’ perceptions of and attitudes toward female menopause: a mixed-methods systematic review

description: <b>Objective:</b> Menopausal women experience physical and psychological discomfort, which may be affected by their spouses’ perceptions of and attitudes toward menopause. The purpose of this review is to summarize men’s perceptions of and attitudes toward female menopause in different cultural contexts. <b>Method:</b> A sequential integrated design method was used in this mixed-methods systematic review. PubMed, Web of Science, PsycINFO, Cochrane, Embase, China National Knowledge Infrastructure, and the Wanfang database were searched. Studies on spousal perceptions of and attitudes toward female menopause were included in the analysis. <b>Results:</b> A total of 12 articles met the inclusion criteria. Men have little knowledge of menopause and health-care status. Men have different attitudes toward wives’ changes during menopause. A large proportion of them cannot cope with these changes, possibly due to poor knowledge about menopause; aging and disease; psychological changes; religious and other internal factors; and external factors, including family life, work stress, and wives’ menopausal symptoms. In addition, spouses’ perceptions of and attitudes toward menopause may affect women’s menopausal symptoms, attitudes toward menopause, and marriage relationships. <b>Conclusion:</b> Although there was little evidence, it seems that male spouses’ perceptions of and attitudes toward female menopause are important factors affecting menopausal women’s quality of life.
DOI: 10.6084/m9.figshare.11603838
title: Supplemental Table - Number of pixels of tissue types obtained from registered histology in video domain

description: This table shows the number of pixels before and after morphological of tissue types tumor, fibrous, and adipose obtained from registered histology in video domain
DOI: 10.6084/m9.figshare.11603838.v1
title: Supplemental Table - Number of pixels of tissue types obtained from registered histology in video domain

description: This table shows the number of pixels before and after morphological of tissue types tumor, fibrous, and adipose obtained from registered histology in video domain
DOI: 10.6084/m9.figshare.11603781
title: Alpha diversity across 10 forest plots on Sulawesi

description: Hill number measures of tree species alpha diversity from 10 0.25 ha sites in Sulawesi, Indonesia. Soil principal component axes for each site and the region each site belongs too.
DOI: 10.6084/m9.figshare.11603781.v2
title: Alpha diversity across 10 forest plots on Sulawesi

description: Hill number measures of tree species alpha diversity from 10 0.25 ha sites in Sulawesi, Indonesia. Soil principal component axes for each site and the region each site belongs too.
DOI: 10.6084/m9.figshare.11603781.v1
title: Alpha diversity across 10 forest plots on Sulawesi

description: Hill number measures of tree species alpha diversity from 10 0.25 ha sites in Sulawesi, Indonesia. Soil principal component axes for each site and the region each site belongs too.
DOI: 10.6084/m9.figshare.11603712
title: Supplementary Material for: Circulating Endocannabinoids and Mortality in Hemodialysis Patients

description: <b><i>Background:</i></b> Mortality in patients with end-stage renal disease (ESRD) on maintenance hemodialysis (MHD) remains exceptionally high. While traditional risk factors such as obesity are paradoxically associated with better survival, nontraditional risk factors including cachexia increase the likelihood of poor outcomes. There is accumulating evidence that the endocannabinoid (ECB) system plays a major role in energy preservation and storage, factors which can prevent the deleterious effects of cachexia. Hence, in this study, we evaluated the association of circulating ECB levels with mortality in MHD patients. <b><i>Methods:</i></b> Serum concentrations of anandamide (AEA) and 2-arachidonoyl-<i>sn</i>-glycerol (2-AG), major ECB ligands, were measured in MHD patients. Their correlation with various clinical/laboratory indices and association with 12-month all-cause mortality were examined. <b><i>Results:</i></b> Serum 2-AG levels positively correlated with body mass index, serum triglycerides and body anthropometric measures. Meanwhile, serum AEA levels correlated positively with serum interleukin-6, and negatively with serum very low-density lipoprotein levels. While increased serum 2-AG levels were associated with reduced risk of all-cause mortality (hazard ratio [HR] 0.52, 95% CI 0.28–0.98), there was no clear association between serum AEA levels and mortality (HR 0.91, 95% CI 0.48–1.72). <b><i>Conclusions:</i></b> In MHD patients, the circulating levels of ECB ligand, 2-AG, may play an important role in determining body mass and risk of mortality. These observations were unique to 2-AG as similar findings were not obtained with serum AEA. Future studies need to investigate the mechanisms responsible for these associations and examine the modulation of the ECB system as a potential target for therapy in ESRD.