DOI: 10.17035/d.2024.0305407248
title: Complement in Long Covid data

description: Plasma biomarker data for the study "Complement dysregulation is a prevalent and therapeutically amenable feature of long COVID", comprising ELISA generated protein concentrations and sample information. Breakdown of each column:

Sample - Anonymised sample IDs of participant
Phenotype - Long COVID status of participant
Sex - Reported sex of participant
Age - Reported age of participant
BMI - BMI of samples, calculated by weight (kg) divided by height (in metres) squared
Ethnicity - Reported ethnicity of participant
Duration - Reported duration of long-COVID synmptoms in participant
Vaccinations - Number of SARS-CoV-19 vaccinations received by participant
InfectionsNumber - Number of SARS-CoV-19 infections in participant
DaysSinceInfection - Number of days since last SARS-CoV-19 infection reported by participant
iC3b ug/ml - Plasma levels of iC3b measured via an in-house anti-iC3b clone 9 antibody
TCC ug/ml - Plasma levels of the Terminal Complement Complex measured by the Hycult anti-TCC clone aE11 antibody (Cat# HM2167; RRID: AB_533189)
Ba (ug/mL) - Plasma levels of Ba measured via the Hycult anti-Ba clone D22/3 antibody (Cat# HM2379; RRID: N/A)
C1q ug/ml - Plasma levels of C1q measured via an in-house anti-C1q clone 9H10 and anti-C1q rabbit polyclonal antibody
C3 ug/ml - Plasma levels of C3 measured via the Hycult anti-C3/C3a clone 2898 and anti-C3d–HRP clone 3 antibody (Cat# HM2075; RRID: AB_533248 and Cat# HM2198; RRID: AB_920411)
C4 ug/ml - Plasma levels of C4 measured via an in-house anti-C4–HRP and anti-C4 rabbit polyclonal antibody
C5 ug/ml - Plasma levels of C5 measured via an in-house anti-C5 clone 10B6 and anti-C5–biotin clone 4G2 antibody
C9 ug/ml - Plasma levels of C9 measured via an in-house anti-C9 clone B7 and anti-C9–biotin rabbit polyclonal antibody
C1inh ug/ml - Plasma levels of C1inh measured via an in house anti-C1INH rabbit polyclonal and anti-C1INH–HRP rabbit polyclonal antibody
FH ug/ml - Plasma levels of complement Factor H measured via an in-house anti-FH clone OX24 and anti-FH–HRP clone 36H9 antibody
FHR4 ug/ml - Plasma levels of factor H related 4 measured via an in-house Anti-FHR4 clone 4E9 and anti-FHR4–HRP clone 150 antibody
FHR125 ug/ml - Plasma levels of factor H related 1, 2 and 5 measured via an in-house anti-FHR125 clone MBI125 antibody 
FI ug/ml - Plasma levels of factor I measured via an in-house anti-FI clone 7B5 and Anti-FI rabbit polyclonal antibody
Clusterin ug/ml - Plasma levels of C4 measured via an in-house anti-clusterin clone 2D5 and anti-clusterin–HRP clone 4C7
FD ug/ml - Plasma levels of C4 measured via an in-house anti-FD rabbit polyclonal antibody and Hycult anti-FD–HRP clone D10/4 antibody (Cat# HM2258; RRID: AB_10679352)
Properdin ug/ml - Plasma levels of properdin measured via the Hycult anti-properdin clone 9.3.4 and anti-properdin–HRP clone 2.9 (Cat# HM2283; RRID: N/A and Cat# HM2282; RRID: N/A)
FB ug/ml - Plasma levels of Factor B measured via an in-house anti-FB clone JC1 antibody and CompTech Anti-FB goat polyclonal antibody (Cat# A235; RRID: N/A)
CR1 ng/ml - Plasma levels of C4 measured via an in-house anti-sCR1 rabbit polyclonal and anti-sCR1–HRP clone MBI35 antibody
C1s-C1INH - Plasma levels of C4 measured via the Hycult human C1s/C1-INH complex ELISA (Cat# HK399)
MASP1-C1INH - Plasma levels of C4 measured via the Hycult human MASP-1/C1-INH complex ELISA (Cat# HK3001)
C5a pg/ml - Plasma levels of C4 measured via the R&D Systems uman C5a Duoset ELISA (Cat# DY2037)

Data supports the article: https://dx.doi.org/10.1016/j.medj.2024.01.011