cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.3701508
title: O Twitter como dispositivo de mediação da informação em períodos eleitorais

description: THE TWITTER AS A MEDIATION DISPOSITIVE OF INFORMATION DURING ELECTORAL CAMPAIGNO presente estudo explora a mediação da informação no âmbito da comunicação política em sites de redes sociais com foco no Twitter evidenciando o potencial participativo edialógico do microblog. Colabora com a reflexão dialogando-a com resultados parciais de uma pesquisa que tem por objetivo analisar a mediação informacional por meio do monitoramento da interatividade e da conversação entre os cidadãos/eleitores e os principais candidatos ao governo de Alagoas nas eleições de 2014. Para coleta e istematização dos dados utilizou-se o software BrandCare e a análise segue abordagem combinatória da Análise de RedesSociais e da conversação mediada por computador. Com o universo de 524 usuários únicos, trabalhou-se com total de total de 3.409 mensagens, sendo 2.353 únicas, 1.057 retweets. Do total de mensagens únicas, 426 (9,11%) são dos candidatos e 1.927 (81,89%) de outros usuários. Dentre os resultados destacam-se: a) a rede é fragmentada; b) o assunto de maior recorrência é o combate à violência, e c) não houve prolongamento das interações e poucasobtiveram reciprocidade e persistência. Palavras-chave: Participação Política. Mediação da Informação. Twitter. Conversação Mediada por Computador. Análise de Redes Sociais. Abstract: This study explores the mediation in political communication on social networking sites focused on Twitter showing the participatory and dialogic potential of microblogging. Collaborates with reflection dialoguing it with partial results of a research that aims to analyze the informational mediation by monitoring the interaction and conversation between citizens/voters and the main candidates for governor of Alagoas in the 2014 elections. The collection and systematization of data used the BrandCare software and the data analysis followed acombinatorial approach which used both Social Network and conversation mediated by computer analyses. With the universe of 524 unique users, it worked with a total of total of 3,409 tweets, from which 2,353 uniques and 1,057 retweets. A total of 426 (9.11%) of the of unique tweets was posted by candidates, and 1,927 (81.89%) by other users. Findings suggest: a) the network is fragmented; b) fighting violence is the most recurrent subject, and c) there was no extension of the interactions, and only a few obtained reciprocity and persistence
DOI: 10.6084/m9.figshare.3701508.v1
title: O Twitter como dispositivo de mediação da informação em períodos eleitorais

description: THE TWITTER AS A MEDIATION DISPOSITIVE OF INFORMATION DURING ELECTORAL CAMPAIGNO presente estudo explora a mediação da informação no âmbito da comunicação política em sites de redes sociais com foco no Twitter evidenciando o potencial participativo edialógico do microblog. Colabora com a reflexão dialogando-a com resultados parciais de uma pesquisa que tem por objetivo analisar a mediação informacional por meio do monitoramento da interatividade e da conversação entre os cidadãos/eleitores e os principais candidatos ao governo de Alagoas nas eleições de 2014. Para coleta e istematização dos dados utilizou-se o software BrandCare e a análise segue abordagem combinatória da Análise de RedesSociais e da conversação mediada por computador. Com o universo de 524 usuários únicos, trabalhou-se com total de total de 3.409 mensagens, sendo 2.353 únicas, 1.057 retweets. Do total de mensagens únicas, 426 (9,11%) são dos candidatos e 1.927 (81,89%) de outros usuários. Dentre os resultados destacam-se: a) a rede é fragmentada; b) o assunto de maior recorrência é o combate à violência, e c) não houve prolongamento das interações e poucasobtiveram reciprocidade e persistência. Palavras-chave: Participação Política. Mediação da Informação. Twitter. Conversação Mediada por Computador. Análise de Redes Sociais. Abstract: This study explores the mediation in political communication on social networking sites focused on Twitter showing the participatory and dialogic potential of microblogging. Collaborates with reflection dialoguing it with partial results of a research that aims to analyze the informational mediation by monitoring the interaction and conversation between citizens/voters and the main candidates for governor of Alagoas in the 2014 elections. The collection and systematization of data used the BrandCare software and the data analysis followed acombinatorial approach which used both Social Network and conversation mediated by computer analyses. With the universe of 524 unique users, it worked with a total of total of 3,409 tweets, from which 2,353 uniques and 1,057 retweets. A total of 426 (9.11%) of the of unique tweets was posted by candidates, and 1,927 (81.89%) by other users. Findings suggest: a) the network is fragmented; b) fighting violence is the most recurrent subject, and c) there was no extension of the interactions, and only a few obtained reciprocity and persistence
DOI: 10.6084/m9.figshare.3699162
title: Geographically widespread mitochondrial lineages of the African saw-wings inconsistent with species boundaries

description: The African saw-wings (genus <i>Psalidoprocne</i>) are a group of swallows endemic to sub-Saharan Africa. Although currently described as five species with several subspecies, the taxonomy of the saw-wings is unclear. We sequenced two mitochondrial genes (ND2 and cytb; 1 717 sites) from 20 individuals in order to investigate phylogenetic relationships across the range of <i>Psalidoprocne</i>. We obtained similar results from maximum likelihood (RAxML) and Bayesian (BEAST) phylogenetic analyses, which reveal multiple well-supported mitochondrial clades in the genus. The geographic overlap of distinct lineages suggests reproductive isolation, although these clades do not correspond entirely to current species designations.
DOI: 10.6084/m9.figshare.3699162.v2
title: Geographically widespread mitochondrial lineages of the African saw-wings inconsistent with species boundaries

description: The African saw-wings (genus <i>Psalidoprocne</i>) are a group of swallows endemic to sub-Saharan Africa. Although currently described as five species with several subspecies, the taxonomy of the saw-wings is unclear. We sequenced two mitochondrial genes (ND2 and cytb; 1 717 sites) from 20 individuals in order to investigate phylogenetic relationships across the range of <i>Psalidoprocne</i>. We obtained similar results from maximum likelihood (RAxML) and Bayesian (BEAST) phylogenetic analyses, which reveal multiple well-supported mitochondrial clades in the genus. The geographic overlap of distinct lineages suggests reproductive isolation, although these clades do not correspond entirely to current species designations.
DOI: 10.6084/m9.figshare.3699147
title: Methodological quality, completeness of reporting, and use of systematic reviews as evidence in clinical practice guidelines for pediatric overweight and obesity

description: This data is the Google sheets export of the google form data we gathered from our included systematic records in pediatric obesity. We scored the systematic reviews using the PRISMA and AMSTAR tools for methodological and reporting quality.
DOI: 10.6084/m9.figshare.3699147.v1
title: Methodological quality, completeness of reporting, and use of systematic reviews as evidence in clinical practice guidelines for pediatric overweight and obesity

description: This data is the Google sheets export of the google form data we gathered from our included systematic records in pediatric obesity. We scored the systematic reviews using the PRISMA and AMSTAR tools for methodological and reporting quality.
DOI: 10.6084/m9.figshare.3698895
title: Valid publications

description: Table with the 21 scientific papers analysed in 'The use of virtual worlds in foreign language learning'. <br>
DOI: 10.6084/m9.figshare.3698895.v1
title: FigShare.pdf

description: Table with the 21 scientific papers analysed in 'The use of virtual worlds in foreign language learning'. <br>
DOI: 10.6084/m9.figshare.3698895.v2
title: Valid publications

description: Table with the 21 scientific papers analysed in 'The use of virtual worlds in foreign language learning'. <br>
DOI: 10.6084/m9.figshare.3698895.v3
title: Valid publications

description: Table with the 21 scientific papers analysed in 'The use of virtual worlds in foreign language learning'. <br>
DOI: 10.6084/m9.figshare.3698895.v5
title: Valid publications

description: Table with the 21 scientific papers analysed in 'The use of virtual worlds in foreign language learning'. <br>
DOI: 10.6084/m9.figshare.3698895.v4
title: Valid publications

description: Table with the 21 scientific papers analysed in 'The use of virtual worlds in foreign language learning'. <br>
DOI: 10.6084/m9.figshare.3697203
title: Comparative efficacy of oral nucleotide analogues for the prophylaxis of hepatitis B virus recurrence after liver transplantation: a network meta-analysis

description: <b>Background:</b> Prophylactic nucleos(t)ide anologues against hepatitis B virus (HBV) recurrence after liver transplantation (LT) include lamivudine, entecavir, tenofovir, adefovir. Since the most effective strategies for post-LT remain inconclusive, we aimed to compare 6 different treatment options (lamivudine, entecavir, tenofovir, adefovir, lamivudine plus adefovir, lamivudine plus tenofovir) in terms of HBV recurrence after LT using network meta-analysis. <b>Methods:</b> The search identified seventeen studies involving 6 different prophylactic regimens covering 7274 patients. <b>Results:</b> Compared with entecavir, lamivudine plus tenofovir (OR 2.00, 95%CI 0.02-183.29), lamivudine plus adefovir, (OR 2.83, 95%CI 0.18-33.57), tenofovir (OR 1.11, 95%CI 0.22-5.80), adefovir (OR 3.78, 95%CI 0.59-22.16), lamivudine (OR 4.62, 95%CI 1.75-11.39) were associated with an increased risk of HBV recurrence. <b>Conclusion:</b> Entecavir resulted with the highest probability (31%) as the best prophylactic option on reducing the risk of HBV recurrence. Entecavir is the preferred oral NAs treatment compared to other five different prophylactic regimens in the prevention of HBV recurrence after LT.
DOI: 10.6084/m9.figshare.3697203.v1
title: Comparative efficacy of oral nucleotide analogues for the prophylaxis of hepatitis B virus recurrence after liver transplantation: a network meta-analysis

description: <b>Background:</b> Prophylactic nucleos(t)ide anologues against hepatitis B virus (HBV) recurrence after liver transplantation (LT) include lamivudine, entecavir, tenofovir, adefovir. Since the most effective strategies for post-LT remain inconclusive, we aimed to compare 6 different treatment options (lamivudine, entecavir, tenofovir, adefovir, lamivudine plus adefovir, lamivudine plus tenofovir) in terms of HBV recurrence after LT using network meta-analysis. <b>Methods:</b> The search identified seventeen studies involving 6 different prophylactic regimens covering 7274 patients. <b>Results:</b> Compared with entecavir, lamivudine plus tenofovir (OR 2.00, 95%CI 0.02-183.29), lamivudine plus adefovir, (OR 2.83, 95%CI 0.18-33.57), tenofovir (OR 1.11, 95%CI 0.22-5.80), adefovir (OR 3.78, 95%CI 0.59-22.16), lamivudine (OR 4.62, 95%CI 1.75-11.39) were associated with an increased risk of HBV recurrence. <b>Conclusion:</b> Entecavir resulted with the highest probability (31%) as the best prophylactic option on reducing the risk of HBV recurrence. Entecavir is the preferred oral NAs treatment compared to other five different prophylactic regimens in the prevention of HBV recurrence after LT.
DOI: 10.6084/m9.figshare.3696369
title: Supplementary Material for: Does Schizophrenia in Offspring Increase the Risk of Developing Alzheimer's Dementia?

description: <b><i>Background/Aims:</i></b> Prior studies have consistently found a higher risk of dementia in individuals with schizophrenia, but whether this is due to a common etiology between the disorders remains obscure. We wanted to elucidate this association by investigating whether schizophrenia in offspring increases the risk of Alzheimer's dementia. <b><i>Methods:</i></b> All individuals born between 1930 and 1953 were identified through national registers and followed from their 50th birthday until the date of Alzheimer's dementia, death or end of the study. Regressions were performed to evaluate the association between offspring with schizophrenia and Alzheimer's dementia. <b><i>Results:</i></b> Individuals with offspring with schizophrenia did not have an increased risk of Alzheimer's dementia [incidence rate ratio (IRR), 0.97; 95% CI, 0.88-1.07] compared to individuals with offspring without psychiatric contact. This finding remained stable when evaluating early-onset (IRR, 1.10; 95% CI, 0.91-1.31) and late-onset Alzheimer's dementia (IRR, 0.92; 95% CI, 0.88-1.07). Similar findings were made for vascular and unspecified dementia. <b><i>Conclusion:</i></b> The finding of no familial coaggregation between schizophrenia and Alzheimer's dementia may suggest that no common etiology between the disorders exists. This may indicate that the excess risk of dementia in individuals with schizophrenia is a by-product of the higher rates of somatic comorbidity and adverse health risk factors among these individuals.
DOI: 10.6084/m9.figshare.3696369.v1
title: Supplementary Material for: Does Schizophrenia in Offspring Increase the Risk of Developing Alzheimer's Dementia?

description: <b><i>Background/Aims:</i></b> Prior studies have consistently found a higher risk of dementia in individuals with schizophrenia, but whether this is due to a common etiology between the disorders remains obscure. We wanted to elucidate this association by investigating whether schizophrenia in offspring increases the risk of Alzheimer's dementia. <b><i>Methods:</i></b> All individuals born between 1930 and 1953 were identified through national registers and followed from their 50th birthday until the date of Alzheimer's dementia, death or end of the study. Regressions were performed to evaluate the association between offspring with schizophrenia and Alzheimer's dementia. <b><i>Results:</i></b> Individuals with offspring with schizophrenia did not have an increased risk of Alzheimer's dementia [incidence rate ratio (IRR), 0.97; 95% CI, 0.88-1.07] compared to individuals with offspring without psychiatric contact. This finding remained stable when evaluating early-onset (IRR, 1.10; 95% CI, 0.91-1.31) and late-onset Alzheimer's dementia (IRR, 0.92; 95% CI, 0.88-1.07). Similar findings were made for vascular and unspecified dementia. <b><i>Conclusion:</i></b> The finding of no familial coaggregation between schizophrenia and Alzheimer's dementia may suggest that no common etiology between the disorders exists. This may indicate that the excess risk of dementia in individuals with schizophrenia is a by-product of the higher rates of somatic comorbidity and adverse health risk factors among these individuals.
DOI: 10.6084/m9.figshare.3695943
title: Supplementary Material for: Granulocyte Colony-Stimulating Factor Ameliorates Skeletal Muscle Dysfunction in Amyotrophic Lateral Sclerosis Mice and Improves Proliferation of SOD1-G93A Myoblasts in vitro

description: <b><i>Background:</i></b> Amyotrophic lateral sclerosis (ALS) causes loss of upper and lower motor neurons as well as skeletal muscle (SKM) dysfunction and atrophy. SKM is one of the tissues involved in the development of ALS pathology, and studies in a SOD1-G93A mouse model of ALS have demonstrated alterations in SKM degeneration/regeneration marker expression in vivo and defective mutant myoblast proliferation in vitro. Granulocyte colony-stimulating factor (G-CSF) has been shown to alleviate SOD1-G93A pathology. However, it is unknown whether G-CSF may have a direct effect on SKM or derived myoblasts. <b><i>Objective:</i></b> To investigate effects of G-CSF and its analog pegfilgrastim (PEGF) on SOD1-G93A- associated SKM markers in vivo and those of G-CSF on myoblast proliferation in vitro. <b><i>Methods:</i></b> The effect of PEGF treatment on hematopoietic stem cell mobilization, survival, and motor function was determined. RNA expression of SKM markers associated with mutant SOD1 expression was quantified in response to PEGF treatment in vivo, and the effect of G-CSF on the proliferation of myoblasts derived from mutant and control muscles was determined in vitro. <b><i>Results:</i></b> Positive effects of PEGF on hematopoietic stem cell mobilization, survival, and functional assays in SOD1-G93A animals were confirmed. In vivo PEGF treatment augmented the expression of its receptor Csf3r and alleviated typical markers for mutant SOD1 muscle. Additionally, G-CSF was found to directly increase the proliferation of SOD1-G93A, but not wild-type primary myoblasts in vitro. <b><i>Conclusion:</i></b> Our results support the beneficial role of the G-CSF analog PEGF in a SOD1-G93A model of ALS. Thus, G-CSF and<b> </b>its analogs may be directly beneficial in diseases where the SKM function is compromised.
DOI: 10.6084/m9.figshare.3695943.v1
title: Supplementary Material for: Granulocyte Colony-Stimulating Factor Ameliorates Skeletal Muscle Dysfunction in Amyotrophic Lateral Sclerosis Mice and Improves Proliferation of SOD1-G93A Myoblasts in vitro

description: <b><i>Background:</i></b> Amyotrophic lateral sclerosis (ALS) causes loss of upper and lower motor neurons as well as skeletal muscle (SKM) dysfunction and atrophy. SKM is one of the tissues involved in the development of ALS pathology, and studies in a SOD1-G93A mouse model of ALS have demonstrated alterations in SKM degeneration/regeneration marker expression in vivo and defective mutant myoblast proliferation in vitro. Granulocyte colony-stimulating factor (G-CSF) has been shown to alleviate SOD1-G93A pathology. However, it is unknown whether G-CSF may have a direct effect on SKM or derived myoblasts. <b><i>Objective:</i></b> To investigate effects of G-CSF and its analog pegfilgrastim (PEGF) on SOD1-G93A- associated SKM markers in vivo and those of G-CSF on myoblast proliferation in vitro. <b><i>Methods:</i></b> The effect of PEGF treatment on hematopoietic stem cell mobilization, survival, and motor function was determined. RNA expression of SKM markers associated with mutant SOD1 expression was quantified in response to PEGF treatment in vivo, and the effect of G-CSF on the proliferation of myoblasts derived from mutant and control muscles was determined in vitro. <b><i>Results:</i></b> Positive effects of PEGF on hematopoietic stem cell mobilization, survival, and functional assays in SOD1-G93A animals were confirmed. In vivo PEGF treatment augmented the expression of its receptor Csf3r and alleviated typical markers for mutant SOD1 muscle. Additionally, G-CSF was found to directly increase the proliferation of SOD1-G93A, but not wild-type primary myoblasts in vitro. <b><i>Conclusion:</i></b> Our results support the beneficial role of the G-CSF analog PEGF in a SOD1-G93A model of ALS. Thus, G-CSF and<b> </b>its analogs may be directly beneficial in diseases where the SKM function is compromised.
DOI: 10.6084/m9.figshare.3695652
title: Supplementary Material for: Whole-Exome Sequencing Identifies Two Novel TTN Mutations in Chinese Families with Dilated Cardiomyopathy

description: <b><i>Objectives:</i></b> Dilated cardiomyopathy (DCM) is a leading cause of sudden cardiac death. So far, only 127 mutations of <i>Titin</i><i>(TTN)</i> have been reported in patients with different phenotypes such as isolated cardiomyopathies, purely skeletal muscle phenotypes or complex overlapping disorders of muscles. <b><i>Methods:</i></b> We applied whole-exome sequencing (WES) to investigate cardiomyopathy patients and a cardiomyopathy-related gene-filtering strategy was used to analyze the disease-causing mutations. Sanger sequencing was applied to confirm the mutation cosegregation in the affected families. <b><i>Results:</i></b> A nonsense mutation (c.12325C&gt;T/p.R4109X) and a missense mutation (c.17755G&gt;C/p.G5919R) of <i>TTN</i> were identified in 2 Chinese DCM families, respectively. Both mutations were cosegregated in all affected members of both families. The nonsense mutation is predicted to result in a truncated TTN protein and the missense mutation leads to a substitution of glycine by arginine. Both variants may cause the structure changes of titin protein. <b><i>Conclusions:</i></b> We employed WES to detect the mutations of DCM patients and identified 2 novel mutations. Our study expands the spectrum of <i>TTN</i> mutations and offers accurate genetic testing information for DCM patients who are still clinically negative.
DOI: 10.6084/m9.figshare.3695652.v1
title: Supplementary Material for: Whole-Exome Sequencing Identifies Two Novel TTN Mutations in Chinese Families with Dilated Cardiomyopathy

description: <b><i>Objectives:</i></b> Dilated cardiomyopathy (DCM) is a leading cause of sudden cardiac death. So far, only 127 mutations of <i>Titin</i><i>(TTN)</i> have been reported in patients with different phenotypes such as isolated cardiomyopathies, purely skeletal muscle phenotypes or complex overlapping disorders of muscles. <b><i>Methods:</i></b> We applied whole-exome sequencing (WES) to investigate cardiomyopathy patients and a cardiomyopathy-related gene-filtering strategy was used to analyze the disease-causing mutations. Sanger sequencing was applied to confirm the mutation cosegregation in the affected families. <b><i>Results:</i></b> A nonsense mutation (c.12325C&gt;T/p.R4109X) and a missense mutation (c.17755G&gt;C/p.G5919R) of <i>TTN</i> were identified in 2 Chinese DCM families, respectively. Both mutations were cosegregated in all affected members of both families. The nonsense mutation is predicted to result in a truncated TTN protein and the missense mutation leads to a substitution of glycine by arginine. Both variants may cause the structure changes of titin protein. <b><i>Conclusions:</i></b> We employed WES to detect the mutations of DCM patients and identified 2 novel mutations. Our study expands the spectrum of <i>TTN</i> mutations and offers accurate genetic testing information for DCM patients who are still clinically negative.
DOI: 10.6084/m9.figshare.3695391
title: Supplementary Material for: Preclinical Evaluation of AdVince, an Oncolytic Adenovirus Adapted for Treatment of Liver Metastases from Neuroendocrine Cancer

description: Cancer immunotherapy is becoming a cornerstone in the clinical care of cancer patients due to the breakthrough trials with immune checkpoint blockade antibodies and chimeric antigen receptor T cells. The next breakthrough in cancer immunotherapy is likely to be oncolytic viruses engineered to selectively kill tumor cells and deceive the immune system to believe that the tumor is a foreign entity that needs to be eradicated. We have developed AdVince, an oncolytic adenovirus for treatment of liver metastases from neuroendocrine tumor (NET). AdVince includes the gene promoter from human chromogranin A for selective replication in neuroendocrine cells, miR122 target sequences for reduced liver toxicity, and a cell-penetrating peptide in the capsid for increased infectivity of tumor cells and optimized spread within tumors. This paper describes the preclinical evaluation of AdVince on freshly isolated human gastrointestinal NET cells resected from liver metastases and freshly isolated human hepatocytes as well as in fresh human blood. AdVince selectively replicates in and kills NET cells. Approximately 73-fold higher concentration of AdVince is needed to induce a similar level of cytotoxicity in NET cells as in hepatocytes. AdVince did not activate complement or induce considerable amount of proinflammatory cytokines or chemokines in human blood. The data presented herein indicate that AdVince can be safely evaluated in a phase I/IIa clinical trial for patients with liver-dominant NET.