cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.6179930.v1
title: LncRNA HULC mediates radioresistance via autophagy in prostate cancer cells

description: Prostate cancer (PCa) is the second leading cause of cancer death in men. Irradiation is one of the available options for treatment of PCa, however, approximately 10–45% of PCa are resistant to irradiation. We aimed to explore the role of long non-coding RNA highly upregulated in liver cancer (HULC) in the sensitivity of PCa cells to irradiation. Survival rate, cell apoptosis, cycle, expressions of related proteins, and caspase-3 activity were assessed to explore the effects of HULC on sensitivity of PCa cells to irradiation. Expression of HULC in DU-145, PC3, LNCaP, and RWPE-1 cells was determined and the influence of HULC on DU-145 cells was explored. Then, PC3 cells aberrantly expressing HULC were implanted into NOD-SCID mice for tumor xenograft study. Changes of autophagy after aberrant expression of HULC in vivo and in vitro were tested. Furthermore, the interacted protein of HULC and involved signaling pathway were investigated. In PC3 and LNCaP cells under irradiation, survival rate and cell cycle were decreased and apoptosis was increased by HULC knockdown. HULC knockdown arrested PC3 cells at G0/G1 phase. DU-145 was sensitive to irradiation, and resistance to irradiation of DU-145 cells was enhanced by HULC overexpression. Moreover, HULC knockdown enhanced the sensitivity of PC3 xenografts to irradiation. HULC knockdown promoted autophagy through interaction with Beclin-1 and inhibition of mTOR, resulting in increased apoptosis. HULC knockdown improved sensitivity of PCa cells to irradiation both in vivo and in vitro. HULC suppressed Beclin-1 phosphorylation, thereby reduced autophagy, involving the mTOR pathway.
DOI: 10.6084/m9.figshare.6181010
title: Data of 5 repeative tests used in figure 5 from A plug-in electrophoresis microchip with PCB electrodes for contactless conductivity detection.

description: Data of electrophoreis detection for K+, Na+, Li+(0.5 mM each) in five tests
DOI: 10.6084/m9.figshare.6181010.v2
title: Data of 5 repeative tests used in figure 5 from A plug-in electrophoresis microchip with PCB electrodes for contactless conductivity detection.

description: Data of electrophoreis detection for K+, Na+, Li+(0.5 mM each) in five tests
DOI: 10.6084/m9.figshare.6181010.v1
title: Data of 5 repeative tests used in figure 5 from A plug-in electrophoresis microchip with PCB electrodes for contactless conductivity detection

description: Data of electrophoreis detection for K+, Na+, Li+(0.5 mM each) in five tests
DOI: 10.6084/m9.figshare.6181013
title: Data of concentration grades used in figure 4 from A plug-in electrophoresis microchip with PCB electrodes for contactless conductivity detection.

description: Data of electrophoresis test results with concentration grades of K+, Na+, Li+.
DOI: 10.6084/m9.figshare.6181013.v1
title: Data of concentration grades used in figure 4 from A plug-in electrophoresis microchip with PCB electrodes for contactless conductivity detection

description: Data of electrophoresis test results with concentration grades of K+, Na+, Li+.
DOI: 10.6084/m9.figshare.6181013.v2
title: Data of concentration grades used in figure 4 from A plug-in electrophoresis microchip with PCB electrodes for contactless conductivity detection.

description: Data of electrophoresis test results with concentration grades of K+, Na+, Li+.
DOI: 10.6084/m9.figshare.6181016
title: Data of test performance with different installation shifts from A plug-in electrophoresis microchip with PCB electrodes for contactless conductivity detection.

description: Data of electrophoresis test for K+, Na+, Li+ with different installation shifts between the microchannel layer and the electrode layer.
DOI: 10.6084/m9.figshare.6181016.v1
title: Data of test performance with different installation shifts from A plug-in electrophoresis microchip with PCB electrodes for contactless conductivity detection

description: Data of electrophoresis test for K+, Na+, Li+ with different installation shifts between the microchannel layer and the electrode layer.
DOI: 10.6084/m9.figshare.6181262
title: Additional file 2: of Differential networking meta-analysis of gastric cancer across Asian and American racial groups

description: Table S1. DRN meta-analysis of gastric cancer, https://www.synapse.org/#!Synapse:syn10154163 (XLSX 98Â kb)
DOI: 10.6084/m9.figshare.6181262.v1
title: Additional file 2: of Differential networking meta-analysis of gastric cancer across Asian and American racial groups

description: Table S1. DRN meta-analysis of gastric cancer, https://www.synapse.org/#!Synapse:syn10154163 (XLSX 98Â kb)
DOI: 10.6084/m9.figshare.6181271
title: Additional file 3: of Tumor-originated exosomal lncUEGC1 as a circulating biomarker for early-stage gastric cancer

description: Table S2. Seventy-nine exosomal lncRNAs and mRNAs up-regulated by more than 2-fold in stage I GC patients (n = 10) compared with healthy individuals (n = 5) (Q &lt; 0.00001). (XLSX 21 kb)
DOI: 10.6084/m9.figshare.6181271.v1
title: Additional file 3: of Tumor-originated exosomal lncUEGC1 as a circulating biomarker for early-stage gastric cancer

description: Table S2. Seventy-nine exosomal lncRNAs and mRNAs up-regulated by more than 2-fold in stage I GC patients (n = 10) compared with healthy individuals (n = 5) (Q &lt; 0.00001). (XLSX 21 kb)
DOI: 10.6084/m9.figshare.6181283
title: Additional file 1: of Identification of novel drug targets for diamond-blackfan anemia based on RPS19 gene mutation using protein-protein interaction network

description: Table S1. The identified differently expressed genes are listed in the Table S1. Both upregulated and downregulated genes are given based on the defined criteria. (XLSX 52Â kb)
DOI: 10.6084/m9.figshare.6181289
title: Additional file 4: of Tumor-originated exosomal lncUEGC1 as a circulating biomarker for early-stage gastric cancer

description: Table S3. Two hundred eighty-five exosomal lncRNAs and mRNAs up-regulated by more than 2-fold in culture medium from GCCs (n = 4) compared with HPSECs (n = 4) (Q &lt; 0.00001). (XLSX 47 kb)
DOI: 10.6084/m9.figshare.6181283.v1
title: Additional file 1: of Identification of novel drug targets for diamond-blackfan anemia based on RPS19 gene mutation using protein-protein interaction network

description: Table S1. The identified differently expressed genes are listed in the Table S1. Both upregulated and downregulated genes are given based on the defined criteria. (XLSX 52Â kb)
DOI: 10.6084/m9.figshare.6181289.v1
title: Additional file 4: of Tumor-originated exosomal lncUEGC1 as a circulating biomarker for early-stage gastric cancer

description: Table S3. Two hundred eighty-five exosomal lncRNAs and mRNAs up-regulated by more than 2-fold in culture medium from GCCs (n = 4) compared with HPSECs (n = 4) (Q &lt; 0.00001). (XLSX 47 kb)
DOI: 10.6084/m9.figshare.6181322
title: Additional file 3: of Transcriptomic and metabolic flux analyses reveal shift of metabolic patterns during rice grain development

description: Metabolic flux distribution of primary metabolism in different tissues at booting and mature grain stages. (ZIP 3206Â kb)
DOI: 10.6084/m9.figshare.6181322.v1
title: Additional file 3: of Transcriptomic and metabolic flux analyses reveal shift of metabolic patterns during rice grain development

description: Metabolic flux distribution of primary metabolism in different tissues at booting and mature grain stages. (ZIP 3206Â kb)
DOI: 10.6084/m9.figshare.6181325
title: Additional file 2: of Identification of microRNAs associated with the exogenous spermidine-mediated improvement of high-temperature tolerance in cucumber seedlings (Cucumis sativus L.)

description: Table S1. Detailed information of known miRNAs identified from the CW, CS, HW and HS libraries. (XLSX 21Â kb)
DOI: 10.6084/m9.figshare.6181325.v1
title: Additional file 2: of Identification of microRNAs associated with the exogenous spermidine-mediated improvement of high-temperature tolerance in cucumber seedlings (Cucumis sativus L.)

description: Table S1. Detailed information of known miRNAs identified from the CW, CS, HW and HS libraries. (XLSX 21Â kb)
DOI: 10.6084/m9.figshare.6181343
title: Additional file 3: of Identification of microRNAs associated with the exogenous spermidine-mediated improvement of high-temperature tolerance in cucumber seedlings (Cucumis sativus L.)

description: Table S2. Detailed information of novel miRNA candidates identified from the CW, CS, HW and HS libraries. (XLSX 37Â kb)
DOI: 10.6084/m9.figshare.6181343.v1
title: Additional file 3: of Identification of microRNAs associated with the exogenous spermidine-mediated improvement of high-temperature tolerance in cucumber seedlings (Cucumis sativus L.)

description: Table S2. Detailed information of novel miRNA candidates identified from the CW, CS, HW and HS libraries. (XLSX 37Â kb)
DOI: 10.6084/m9.figshare.6181361
title: Additional file 4: of Identification of microRNAs associated with the exogenous spermidine-mediated improvement of high-temperature tolerance in cucumber seedlings (Cucumis sativus L.)

description: Table S3. List of miRNAs significantly expressed differentially in the HW/CW and HS/CW comparison pairs. (XLSX 279Â kb)
DOI: 10.6084/m9.figshare.6181361.v1
title: Additional file 4: of Identification of microRNAs associated with the exogenous spermidine-mediated improvement of high-temperature tolerance in cucumber seedlings (Cucumis sativus L.)

description: Table S3. List of miRNAs significantly expressed differentially in the HW/CW and HS/CW comparison pairs. (XLSX 279Â kb)
DOI: 10.6084/m9.figshare.6181379
title: Additional file 5: of Identification of microRNAs associated with the exogenous spermidine-mediated improvement of high-temperature tolerance in cucumber seedlings (Cucumis sativus L.)

description: Table S4. List of miRNAs significantly expressed differentially in the CS/CW, HS/CW and HS/HW comparison pairs. (XLSX 276Â kb)
DOI: 10.6084/m9.figshare.6181379.v1
title: Additional file 5: of Identification of microRNAs associated with the exogenous spermidine-mediated improvement of high-temperature tolerance in cucumber seedlings (Cucumis sativus L.)

description: Table S4. List of miRNAs significantly expressed differentially in the CS/CW, HS/CW and HS/HW comparison pairs. (XLSX 276Â kb)
DOI: 10.6084/m9.figshare.6181442
title: Additional file 8: of Identification of microRNAs associated with the exogenous spermidine-mediated improvement of high-temperature tolerance in cucumber seedlings (Cucumis sativus L.)

description: Table S7. The KEGG metabolic pathways of gene candidates targeted by miRNAs responding to high-temperature and spermidine. (XLSX 21Â kb)
DOI: 10.6084/m9.figshare.6181442.v1
title: Additional file 8: of Identification of microRNAs associated with the exogenous spermidine-mediated improvement of high-temperature tolerance in cucumber seedlings (Cucumis sativus L.)

description: Table S7. The KEGG metabolic pathways of gene candidates targeted by miRNAs responding to high-temperature and spermidine. (XLSX 21Â kb)
DOI: 10.6084/m9.figshare.6181511
title: Additional file 1: of CXCL9/10/11, a regulator of PD-L1 expression in gastric cancer

description: Table S1. The first 20 significantly enriched gene pathways in TCGA dataset. (XLS 18Â kb)
DOI: 10.6084/m9.figshare.6181511.v1
title: Additional file 1: of CXCL9/10/11, a regulator of PD-L1 expression in gastric cancer

description: Table S1. The first 20 significantly enriched gene pathways in TCGA dataset. (XLS 18Â kb)
DOI: 10.6084/m9.figshare.6181514
title: Additional file 1: of Identification of genes directly responding to DLK1 signaling in Callipyge sheep

description: Quantitative PCR primer sequences and amplification conditions. (XLSX 13Â kb)
DOI: 10.6084/m9.figshare.6181514.v1
title: Additional file 1: of Identification of genes directly responding to DLK1 signaling in Callipyge sheep

description: Quantitative PCR primer sequences and amplification conditions. (XLSX 13Â kb)
DOI: 10.6084/m9.figshare.6181532
title: Additional file 2: of CXCL9/10/11, a regulator of PD-L1 expression in gastric cancer

description: Table S2. The first 23 significantly enriched gene pathways in GSE15459 dataset. (XLS 21Â kb)
DOI: 10.6084/m9.figshare.6181532.v1
title: Additional file 2: of CXCL9/10/11, a regulator of PD-L1 expression in gastric cancer

description: Table S2. The first 23 significantly enriched gene pathways in GSE15459 dataset. (XLS 21Â kb)
DOI: 10.6084/m9.figshare.6181535
title: Additional file 2: of Identification of genes directly responding to DLK1 signaling in Callipyge sheep

description: The plasmids compositions of effector luciferase assay. (XLSX 9Â kb)
DOI: 10.6084/m9.figshare.6181535.v1
title: Additional file 2: of Identification of genes directly responding to DLK1 signaling in Callipyge sheep

description: The plasmids compositions of effector luciferase assay. (XLSX 9Â kb)
DOI: 10.6084/m9.figshare.6181550
title: Additional file 3: of CXCL9/10/11, a regulator of PD-L1 expression in gastric cancer

description: Table S3. The first 24 pathways significantly enriched gene pathways in GSE62254 dataset. (XLS 19Â kb)
DOI: 10.6084/m9.figshare.6181550.v1
title: Additional file 3: of CXCL9/10/11, a regulator of PD-L1 expression in gastric cancer

description: Table S3. The first 24 pathways significantly enriched gene pathways in GSE62254 dataset. (XLS 19Â kb)
DOI: 10.6084/m9.figshare.6181559
title: Additional file 3: of Identification of genes directly responding to DLK1 signaling in Callipyge sheep

description: Quantitative analysis of gene expression in 7 muscles (log). (XLSX 16Â kb)
DOI: 10.6084/m9.figshare.6181559.v1
title: Additional file 3: of Identification of genes directly responding to DLK1 signaling in Callipyge sheep

description: Quantitative analysis of gene expression in 7 muscles (log). (XLSX 16Â kb)
DOI: 10.6084/m9.figshare.6181577
title: Additional file 4: of CXCL9/10/11, a regulator of PD-L1 expression in gastric cancer

description: Table S4. 81 genes that had a close relationship to PD-L1 were selected for Gene functional classification after spearman correlation analysis. (XLS 25Â kb)
DOI: 10.6084/m9.figshare.6181577.v1
title: Additional file 4: of CXCL9/10/11, a regulator of PD-L1 expression in gastric cancer

description: Table S4. 81 genes that had a close relationship to PD-L1 were selected for Gene functional classification after spearman correlation analysis. (XLS 25Â kb)
DOI: 10.6084/m9.figshare.6181580
title: Additional file 4: of Identification of genes directly responding to DLK1 signaling in Callipyge sheep

description: Analysis of variance of genotype effects in qPCR analysis. (XLSX 14Â kb)
DOI: 10.6084/m9.figshare.6181580.v1
title: Additional file 4: of Identification of genes directly responding to DLK1 signaling in Callipyge sheep

description: Analysis of variance of genotype effects in qPCR analysis. (XLSX 14Â kb)
DOI: 10.6084/m9.figshare.6181598
title: Additional file 5: of CXCL9/10/11, a regulator of PD-L1 expression in gastric cancer

description: Table S5. CXCL9/10/11 and CCL4 were grouped together after Gene functional classification in DAVID. (XLS 20Â kb)
DOI: 10.6084/m9.figshare.6181598.v1
title: Additional file 5: of CXCL9/10/11, a regulator of PD-L1 expression in gastric cancer

description: Table S5. CXCL9/10/11 and CCL4 were grouped together after Gene functional classification in DAVID. (XLS 20Â kb)
DOI: 10.6084/m9.figshare.6181610
title: Additional file 2: of PPI network analyses of human WD40 protein family systematically reveal their tendency to assemble complexes and facilitate the complex predictions

description: Table S1. ALL-PPI (including HC-PPI) interactions annotated with confidence scores and PCCs. (XLSX 9754 kb)
DOI: 10.6084/m9.figshare.6181610.v1
title: Additional file 2: of PPI network analyses of human WD40 protein family systematically reveal their tendency to assemble complexes and facilitate the complex predictions

description: Table S1. ALL-PPI (including HC-PPI) interactions annotated with confidence scores and PCCs. (XLSX 9754 kb)
DOI: 10.6084/m9.figshare.6181631
title: Additional file 3: of PPI network analyses of human WD40 protein family systematically reveal their tendency to assemble complexes and facilitate the complex predictions

description: Table S8. Maximal cliques derived from HC_PPI network. (XLSX 103 kb)
DOI: 10.6084/m9.figshare.6181631.v1
title: Additional file 3: of PPI network analyses of human WD40 protein family systematically reveal their tendency to assemble complexes and facilitate the complex predictions

description: Table S8. Maximal cliques derived from HC_PPI network. (XLSX 103 kb)
DOI: 10.6084/m9.figshare.6181649
title: Additional file 4: of PPI network analyses of human WD40 protein family systematically reveal their tendency to assemble complexes and facilitate the complex predictions

description: Table S10. Reference human WD40 complexes derived from the CORUM database. (XLSX 27 kb)
DOI: 10.6084/m9.figshare.6181649.v1
title: Additional file 4: of PPI network analyses of human WD40 protein family systematically reveal their tendency to assemble complexes and facilitate the complex predictions

description: Table S10. Reference human WD40 complexes derived from the CORUM database. (XLSX 27 kb)
DOI: 10.6084/m9.figshare.6182027
title: Numerical modelling of ion transport in flames

description: This paper presents a modelling framework to compute the diffusivity and mobility of ions in flames. The (<i>n</i>, 6, 4) interaction potential is adopted to model collisions between neutral and charged species. All required parameters in the potential are related to the polarizability of the species pair via semi-empirical formulas, which are derived using the most recently published data or best estimates. The resulting framework permits computation of the transport coefficients of any ion found in a hydrocarbon flame. The accuracy of the proposed method is evaluated by comparing its predictions with experimental data on the mobility of selected ions in single-component neutral gases. Based on this analysis, the value of a model constant available in the literature is modified in order to improve the model's predictions. The newly determined ion transport coefficients are used as part of a previously developed numerical approach to compute the distribution of charged species in a freely propagating premixed lean CH<sub>4</sub>/O<sub>2</sub> flame. Since a significant scatter of polarizability data exists in the literature, the effects of changes in polarizability on ion transport properties and the spatial distribution of ions in flames are explored. Our analysis shows that changes in polarizability propagate with decreasing effect from binary transport coefficients to species number densities. We conclude that the chosen polarizability value has a limited effect on the ion distribution in freely propagating flames. We expect that the modelling framework proposed here will benefit future efforts in modelling the effect of external voltages on flames. Supplemental data for this article can be accessed at http://dx.doi.org/10.1080/13647830.2015.1090018.
DOI: 10.6084/m9.figshare.6182027.v1
title: Numerical modelling of ion transport in flames

description: This paper presents a modelling framework to compute the diffusivity and mobility of ions in flames. The (<i>n</i>, 6, 4) interaction potential is adopted to model collisions between neutral and charged species. All required parameters in the potential are related to the polarizability of the species pair via semi-empirical formulas, which are derived using the most recently published data or best estimates. The resulting framework permits computation of the transport coefficients of any ion found in a hydrocarbon flame. The accuracy of the proposed method is evaluated by comparing its predictions with experimental data on the mobility of selected ions in single-component neutral gases. Based on this analysis, the value of a model constant available in the literature is modified in order to improve the model's predictions. The newly determined ion transport coefficients are used as part of a previously developed numerical approach to compute the distribution of charged species in a freely propagating premixed lean CH<sub>4</sub>/O<sub>2</sub> flame. Since a significant scatter of polarizability data exists in the literature, the effects of changes in polarizability on ion transport properties and the spatial distribution of ions in flames are explored. Our analysis shows that changes in polarizability propagate with decreasing effect from binary transport coefficients to species number densities. We conclude that the chosen polarizability value has a limited effect on the ion distribution in freely propagating flames. We expect that the modelling framework proposed here will benefit future efforts in modelling the effect of external voltages on flames. Supplemental data for this article can be accessed at http://dx.doi.org/10.1080/13647830.2015.1090018.
DOI: 10.6084/m9.figshare.6182612
title: Datasets from Interaction between polymorphisms in cell-cycle genes and environmental factors in regulating cholinesterase activity in people with exposure to omethoate

description: Cholinesterase activity (ChA), the effective biomarker for organophosphate pesticide exposure, is possibly affected by single nucleotide polymorphisms (SNPs) in cell-cycle-related genes. One hundred and eighty workers with long-term exposure to omethoate and 115 healthy controls were recruited to explore the gene–gene and gene–environment interactions. The acetylthiocholine and dithio-bis-(nitrobenzoic acid) method was used to detect the cholinesterase activities in whole blood, erythrocyte and plasma. Genetic polymorphisms were determined by the PCR-RFLP and direct PCR electrophoresis methods. Statistical results showed that the cholinesterase activities of whole blood, erythrocyte and plasma in the exposure group were significantly lower than those in the control group (<i>p </i>&lt; 0.001), and erythrocyte cholinesterase activities were associated with gender, smoking and drinking in the exposure group (<i>p </i>&lt; 0.05). Single-locus analyses showed that there is a statistically significant difference in the ChA among the genotypes CC, CA and AA of the <i>p21</i> rs1801270 locus in the control group (<i>p </i>= 0.033), but not in the exposure group. A significant interaction between genes and environmental factors (i.e. <i>p53</i>, <i>p21</i>, <i>mdm2,</i> gender, smoking and drinking) affecting ChA was found through a generalized multifactor dimensionality reduction analysis. These obtained markers will be useful in further marker-assisted selection in workers with exposure to omethoate.