cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.13379025.v2
title: Epigenome-wide association study and network analysis for IgA Nephropathy from CD19<sup>+</sup> B-cell in Chinese Population

description: IgA nephropathy (IgAN) is the most common primary glomerular disease in China and worldwide. The proliferation of B cells is known to be associated with both risk and prognosis of IgAN, but the epigenetic mechanism underlying this association is unknown. In this study we carried out the first Epigenome-wide Association Study (EWAS) by using the latest Infinium Methylation EPIC BeadChip on 184 B cell-specific samples (92 case/control pairs) for Chinese IgAN population. After rigorous data normalization and residual batch effect correction, linear mixed effect model was used to detect methylation CpG sites associated with IgAN adjusting for age, gender and smoking. False discovery rate (<i>FDR</i>) less than 10% was used to account for multiple testing. Weighted gene co-methylation networks were generated to identify gene modules highly correlated with IgAN. A permutation test was performed to account for the potential effect of overfitting. After adjusting clinical covariates and potential technical batch effects, three CpGs corresponding to <i>PCDH17, TERT, WDR82</i> genes and three in the intergenic regions passed the genome-wide significant threshold. Methylation network analysis identified an additional IgAN associated gene module, containing 72 significant CpGs including <i>GALNT6, IQSEC1, CDC16 and SYS1</i>, involved in the pathway related to tubular atrophy/interstitial fibrosis of IgAN. These results suggested important DNA methylation and gene targets in CD19<sup>+</sup> B cells for the pathogenesis of IgAN.
DOI: 10.6084/m9.figshare.13379025.v1
title: Epigenome-wide Association Study and Network Analysis for IgA Nephropathy from CD19 + B-cell in Chinese Population

description: IgA nephropathy (IgAN) is the most common primary glomerular disease in China and worldwide. The proliferation of B cells is known to be associated with both risk and prognosis of IgAN, but the epigenetic mechanism underlying this association is unknown. In this study we carried out the first Epigenome-wide Association Study (EWAS) by using the latest Infinium Methylation EPIC BeadChip on 184 B cell-specific samples (92 case/control pairs) for Chinese IgAN population. After rigorous data normalization and residual batch effect correction, linear mixed effect model was used to detect methylation CpG sites associated with IgAN adjusting for age, gender, and smoking. False discovery rate (<i>FDR</i>) less than 10% was used to account for multiple testing. Weighted gene co-methylation networks were generated to identify gene modules highly correlated with IgAN. Permutation test was performed to account for potential effect of overfitting. After adjusting clinical covariates and potential technical batch effects, 3 CpGs corresponding to <i>PCDH17, TERT, WDR82</i> genes and 3 in the intergenic regions passed genome-wide significant threshold. Methylation network analysis identified an additional IgAN associated gene module, containing 72 significant CpGs including <i>GALNT6, IQSEC1, CDC16 and SYS1</i>, involved in the pathway related to tubular atrophy/interstitial fibrosis of IgAN. These results suggested important DNA methylation and gene targets in CD19 + B cells for the pathogenesis of IgAN.
DOI: 10.4121/8e5df55a-42f4-45a3-9336-501c38bc4b85
title: Data underlying the publication: A Novel Tribometer and a Comprehensive Testing Method for Rolling-Sliding Conditions

description: The following dataset corresponds to the tribological tests presented in the article titled <em>"A Novel Tribometer and a Comprehensive Testing Method for</em><em>Rolling-Sliding Conditions"</em> published in Machines MDPI (2023). The objective of this study was to introduce and validate a novel test setup and an experimental methodology based on torque control for tribological testing of rolling-sliding interfaces, with a spotlight on cam-roller contacts. For the validation process, experimental data generated by the novel test setup under different conditions was collected, processed, and analyzed. These quantitative data (in the present dataset) include measurements of speed, traction force, normal force, and braking torque from two different types of tests (i.e., Torque-Mode Traction Tests and Traction Decay Tests), which have been used to construct the plots in the publication mentioned above.
DOI: 10.4121/8e5df55a-42f4-45a3-9336-501c38bc4b85.v1
title: Data underlying the publication: A Novel Tribometer and a Comprehensive Testing Method for Rolling-Sliding Conditions

description: The following dataset corresponds to the tribological tests presented in the article titled <em>"A Novel Tribometer and a Comprehensive Testing Method for</em><em>Rolling-Sliding Conditions"</em> published in Machines MDPI (2023). The objective of this study was to introduce and validate a novel test setup and an experimental methodology based on torque control for tribological testing of rolling-sliding interfaces, with a spotlight on cam-roller contacts. For the validation process, experimental data generated by the novel test setup under different conditions was collected, processed, and analyzed. These quantitative data (in the present dataset) include measurements of speed, traction force, normal force, and braking torque from two different types of tests (i.e., Torque-Mode Traction Tests and Traction Decay Tests), which have been used to construct the plots in the publication mentioned above.
DOI: 10.6084/m9.figshare.8136176
title: Additional file 7: of Nalbuphine suppresses breast cancer stem-like properties and epithelial-mesenchymal transition via the AKT-NFÎşB signaling pathway

description: Table S7. IC50 of nalbuphine in MDA-MB-231, MCF-7 and SK-BR-3 cells. (XLSX 9 kb)
DOI: 10.6084/m9.figshare.8136176.v1
title: Additional file 7: of Nalbuphine suppresses breast cancer stem-like properties and epithelial-mesenchymal transition via the AKT-NFÎşB signaling pathway

description: Table S7. IC50 of nalbuphine in MDA-MB-231, MCF-7 and SK-BR-3 cells. (XLSX 9 kb)
DOI: 10.5281/zenodo.10664507
title: Seed and fruit morphology of Crinodendron brasiliense

description: These data set contains information on the fruit and seed morphology and germination and initial growth of a narrow endemic tree species, Crinodendron brasiliense.

Data was collected by Sühs, R.B.; Casali, S.; Novaes, S.K.; Silveira, J.; and Giehl, E.L.H.
DOI: 10.6084/m9.figshare.19146278
title: Alleviative effects of foraging exercise on depressive-like behaviors in chronic mild stress-induced ischemic rat model

description: Poststroke depression (PSD) is a common complication that seriously affects the functional recovery and prognosis of an individual. As some patients with PSD fail to respond to drug therapy, it is urgent to find a viable alternative treatment. An active exercise program known as foraging exercise (FE), using food as bait, was designed. First, focal ischemia and chronic unpredictable mild stress (CUMS) were used to establish a PSD model in rats. FE was then performed for 4 weeks. Body weight and behavioral assessments were conducted at the end of the 4<sup>th</sup> and 8<sup>th</sup> weeks. After 8 weeks, the results revealed that, compared with the PSD group, the behavioral scores of the rats in the PSD/FE group were significantly improved, the expression of Iba-1 in the affected frontal lobe and striatum was decreased, and serum levels of IL-6 and the IL-6/IL-10 ratio were downregulated. However, the ratio of residual brain volume in rats that had experienced CUMS was significantly less than that in the stroke group. FE can alleviate the behavioral scores of PSD rats, and its mechanism may be related to a modulation of the immune-inflammation response of microglia. Furthermore, chronic, persistent stress may increase the volume of cerebral infarction after stroke.
DOI: 10.6084/m9.figshare.19146278.v1
title: Alleviative effects of foraging exercise on depressive-like behaviors in chronic mild stress-induced ischemic rat model

description: Poststroke depression (PSD) is a common complication that seriously affects the functional recovery and prognosis of an individual. As some patients with PSD fail to respond to drug therapy, it is urgent to find a viable alternative treatment. An active exercise program known as foraging exercise (FE), using food as bait, was designed. First, focal ischemia and chronic unpredictable mild stress (CUMS) were used to establish a PSD model in rats. FE was then performed for 4 weeks. Body weight and behavioral assessments were conducted at the end of the 4<sup>th</sup> and 8<sup>th</sup> weeks. After 8 weeks, the results revealed that, compared with the PSD group, the behavioral scores of the rats in the PSD/FE group were significantly improved, the expression of Iba-1 in the affected frontal lobe and striatum was decreased, and serum levels of IL-6 and the IL-6/IL-10 ratio were downregulated. However, the ratio of residual brain volume in rats that had experienced CUMS was significantly less than that in the stroke group. FE can alleviate the behavioral scores of PSD rats, and its mechanism may be related to a modulation of the immune-inflammation response of microglia. Furthermore, chronic, persistent stress may increase the volume of cerebral infarction after stroke.
DOI: 10.6084/m9.figshare.12854838
title: <i>Taoheodon baizhijuni</i>, gen. et sp. nov. (Anomodontia, Dicynodontoidea), from the upper Permian Sunjiagou Formation of China and its implications

description: Recently, <i>Repelinosaurus robustus</i> from Laos was proposed as the basal-most member of Kannemeyeriiformes and regarded as Early Triassic in age. A new dicynodont specimen from the Sunjiagou Formation of Shanxi, China, is described and named as <i>Taoheodon baizhijuni</i>, gen. et sp. nov. It is characterized by autapomorphies such as a shallow fossa on a triangular region at the proximal side of the postorbital bar, a basisphenoid contribution to the basisphenoid-basioccipital tubera that slopes anterodorsally at a shallow angle, and the absence of a pterygoid keel. It is further differentiated from other dicynodontoids by the combination of characters such as a narrow median pterygoid plate, a pterygoid that does not contact the maxilla, an occipital condyle that is wide and arc-like in posterior view, and without a circular central depression or fossa, and the lateral dentary shelf that is thin but with distinct dorsal and ventral surfaces. A phylogenetic analysis recovers <i>T. baizhijuni</i> as sister taxon of the Laotian <i>Counillonia superoculis</i> plus <i>Repelinosaurus robustus</i>, a ‘core-<i>Dicynodon</i>’ clade that includes species from Africa, Russia, China, and Laos. Based on the current phylogenetic and geological evidence, the Laotian dicynodonts should be late Permian rather than Early Triassic in age. The migration route of the Laotian clade should have passed through the east margin of the South China Block.
DOI: 10.6084/m9.figshare.12854840
title: A Shock Tube Study of Ethylene/Air Ignition Characteristics over a Wide Temperature Range

description: As a key intermediate product, ethylene plays an important role in the combustion of heavy hydrocarbons. Very limited experiments have focused on the high temperature (&gt;1000 K) ethylene ignition at the real fuel–air condition, but no one on the ethylene/air ignition at low temperatures (&lt;1000 K). In the present work, ignition delay times of ethylene/air mixtures were measured at temperatures of 721 to 1307 K, pressures of 0.97 to 20.54 atm, and equivalence ratios of 0.5, 1.0 and 2.0，and ignition characteristics of ethylene/air were discussed. The high-temperature results show that ignition delay times decrease with the increase of temperature monotonously; the ignition delay of fuel-lean mixture exhibits an unusual behavior of almost zero pressure dependence, and stoichiometric and fuel-rich mixtures still have ordinary pressure dependence, with a pressure increase producing a decrease of ignition delay time. The results at wide temperatures indicate that ethylene/air ignition delay shows no negative temperature coefficient (NTC) behavior at low temperatures, and has an inflection point at the temperature of about 1000 K, showing a two-region ignition feature. The ignition delay times at two regions can be described by Arrhenius-type formulas, respectively, and the ethylene/air ignition delay is much less sensitive to the temperature at the low-temperature region. A good agreement is found between current data and another experimental data for high-temperature ignition. The mechanism used predicts the ethylene/air ignition delay well at high temperatures but must overpredict the ignition delay times at low temperatures. This work contributes to understanding the ethylene ignition properties at a wide temperature range and provides experimental data valuable for validating and refining the chemical kinetics mechanism of ethylene.
DOI: 10.6084/m9.figshare.12854838.v1
title: <i>Taoheodon baizhijuni</i>, gen. et sp. nov. (Anomodontia, Dicynodontoidea), from the upper Permian Sunjiagou Formation of China and its implications

description: Recently, <i>Repelinosaurus robustus</i> from Laos was proposed as the basal-most member of Kannemeyeriiformes and regarded as Early Triassic in age. A new dicynodont specimen from the Sunjiagou Formation of Shanxi, China, is described and named as <i>Taoheodon baizhijuni</i>, gen. et sp. nov. It is characterized by autapomorphies such as a shallow fossa on a triangular region at the proximal side of the postorbital bar, a basisphenoid contribution to the basisphenoid-basioccipital tubera that slopes anterodorsally at a shallow angle, and the absence of a pterygoid keel. It is further differentiated from other dicynodontoids by the combination of characters such as a narrow median pterygoid plate, a pterygoid that does not contact the maxilla, an occipital condyle that is wide and arc-like in posterior view, and without a circular central depression or fossa, and the lateral dentary shelf that is thin but with distinct dorsal and ventral surfaces. A phylogenetic analysis recovers <i>T. baizhijuni</i> as sister taxon of the Laotian <i>Counillonia superoculis</i> plus <i>Repelinosaurus robustus</i>, a ‘core-<i>Dicynodon</i>’ clade that includes species from Africa, Russia, China, and Laos. Based on the current phylogenetic and geological evidence, the Laotian dicynodonts should be late Permian rather than Early Triassic in age. The migration route of the Laotian clade should have passed through the east margin of the South China Block.
DOI: 10.6084/m9.figshare.12854840.v1
title: A Shock Tube Study of Ethylene/Air Ignition Characteristics over a Wide Temperature Range

description: As a key intermediate product, ethylene plays an important role in the combustion of heavy hydrocarbons. Very limited experiments have focused on the high temperature (&gt;1000 K) ethylene ignition at the real fuel–air condition, but no one on the ethylene/air ignition at low temperatures (&lt;1000 K). In the present work, ignition delay times of ethylene/air mixtures were measured at temperatures of 721 to 1307 K, pressures of 0.97 to 20.54 atm, and equivalence ratios of 0.5, 1.0 and 2.0，and ignition characteristics of ethylene/air were discussed. The high-temperature results show that ignition delay times decrease with the increase of temperature monotonously; the ignition delay of fuel-lean mixture exhibits an unusual behavior of almost zero pressure dependence, and stoichiometric and fuel-rich mixtures still have ordinary pressure dependence, with a pressure increase producing a decrease of ignition delay time. The results at wide temperatures indicate that ethylene/air ignition delay shows no negative temperature coefficient (NTC) behavior at low temperatures, and has an inflection point at the temperature of about 1000 K, showing a two-region ignition feature. The ignition delay times at two regions can be described by Arrhenius-type formulas, respectively, and the ethylene/air ignition delay is much less sensitive to the temperature at the low-temperature region. A good agreement is found between current data and another experimental data for high-temperature ignition. The mechanism used predicts the ethylene/air ignition delay well at high temperatures but must overpredict the ignition delay times at low temperatures. This work contributes to understanding the ethylene ignition properties at a wide temperature range and provides experimental data valuable for validating and refining the chemical kinetics mechanism of ethylene.
DOI: 10.6084/m9.figshare.8136257
title: Additional file 1: of Comparative transcriptome analysis revealing the potential mechanism of seed germination stimulated by exogenous gibberellin in Fraxinus hupehensis

description: Table S1. Evaluation of sample sequencing data. (XLSX 9 kb)
DOI: 10.6084/m9.figshare.8136257.v1
title: Additional file 1: of Comparative transcriptome analysis revealing the potential mechanism of seed germination stimulated by exogenous gibberellin in Fraxinus hupehensis

description: Table S1. Evaluation of sample sequencing data. (XLSX 9 kb)
DOI: 10.6084/m9.figshare.8136266
title: Additional file 2: of Comparative transcriptome analysis revealing the potential mechanism of seed germination stimulated by exogenous gibberellin in Fraxinus hupehensis

description: Table S2. All DEGs from the transcriptome of F. hupehensis seeds. (XLSX 5488 kb)
DOI: 10.6084/m9.figshare.8136266.v1
title: Additional file 2: of Comparative transcriptome analysis revealing the potential mechanism of seed germination stimulated by exogenous gibberellin in Fraxinus hupehensis

description: Table S2. All DEGs from the transcriptome of F. hupehensis seeds. (XLSX 5488 kb)
DOI: 10.6084/m9.figshare.8136296
title: Additional file 6: of Comparative transcriptome analysis revealing the potential mechanism of seed germination stimulated by exogenous gibberellin in Fraxinus hupehensis

description: Table S3. Key DEGs related to F. hupehensis seed germination. (XLSX 17 kb)
DOI: 10.6084/m9.figshare.8136296.v1
title: Additional file 6: of Comparative transcriptome analysis revealing the potential mechanism of seed germination stimulated by exogenous gibberellin in Fraxinus hupehensis

description: Table S3. Key DEGs related to F. hupehensis seed germination. (XLSX 17 kb)
DOI: 10.6084/m9.figshare.8136302
title: Additional file 7: of Comparative transcriptome analysis revealing the potential mechanism of seed germination stimulated by exogenous gibberellin in Fraxinus hupehensis

description: Table S4. Differentially expressed TFs related to F. hupehensis seed germination. (XLSX 11 kb)
DOI: 10.6084/m9.figshare.8136302.v1
title: Additional file 7: of Comparative transcriptome analysis revealing the potential mechanism of seed germination stimulated by exogenous gibberellin in Fraxinus hupehensis

description: Table S4. Differentially expressed TFs related to F. hupehensis seed germination. (XLSX 11 kb)
DOI: 10.6084/m9.figshare.8136308
title: Additional file 8: of Comparative transcriptome analysis revealing the potential mechanism of seed germination stimulated by exogenous gibberellin in Fraxinus hupehensis

description: Table S5. Primers used in qRT-PCR. (XLSX 12 kb)
DOI: 10.6084/m9.figshare.8136308.v1
title: Additional file 8: of Comparative transcriptome analysis revealing the potential mechanism of seed germination stimulated by exogenous gibberellin in Fraxinus hupehensis

description: Table S5. Primers used in qRT-PCR. (XLSX 12 kb)
DOI: 10.6084/m9.figshare.8136323
title: MOESM2 of Influence of gene modification in biological behaviors and responses of mouse lung telocytes to inflammation

description: Additional file 2: Table S1. The profiles of transcriptional factor and lncRNA genes (Table S1) between primary lung TCs and TCsSV40 were compared and listed Tables 1 and 2, and the hotmap was shown in Fig. 4.
DOI: 10.6084/m9.figshare.8136323.v1
title: MOESM2 of Influence of gene modification in biological behaviors and responses of mouse lung telocytes to inflammation

description: Additional file 2: Table S1. The profiles of transcriptional factor and lncRNA genes (Table S1) between primary lung TCs and TCsSV40 were compared and listed Tables 1 and 2, and the hotmap was shown in Fig. 4.
DOI: 10.5281/zenodo.10664506
title: Seed and fruit morphology of Crinodendron brasiliense

description: These data set contains information on the fruit and seed morphology and germination and initial growth of a narrow endemic tree species, Crinodendron brasiliense.

Data was collected by Sühs, R.B.; Casali, S.; Novaes, S.K.; Silveira, J.; and Giehl, E.L.H.
DOI: 10.6084/m9.figshare.12855004
title: Identification of a new strain of mouse kidney parvovirus associated with inclusion body nephropathy in immunocompromised laboratory mice

description: Inclusion body nephropathy (IBN) and kidney fibrosis in aged immunodeficient mice and, to lesser extent, in immunocompetent mice have been recently linked to infection of mouse kidney parvovirus (MKPV), also known as murine chapparvovirus (MuCPV). Knowledge about its prevalence and the complete genome sequence of more MKPV strains is essential for understanding phylogenetic relationships and pathogenicity among MKPV strains. In the present study using PCR and genome walking, we determined the complete 4440-nucleotide genome of a new MKPV strain, namely MIT-WI1, which was identified in IBN-affected <i>Il2rg<sup>−/–</sup>Rag2<sup>−/–</sup> c-Kit <sup>W–sh/W–sh</sup></i> mice housed in the vivarium at Whitehead Institute for Biomedical Research (WI). The overall nucleotide (&gt;94%) and deduced amino acid sequences (&gt;98%) of p10, p15, NS1 (replicase), NS2 and VP1 (capsid protein) within the MIT-WI1 genome, are closely related to MKPV/MuCPV strains described in laboratory and wild <i>Mus musculus</i> mice. In addition, PCR and qPCR assays using newly designed primers conserved among the known MKPV/MuCPV genomes were developed and utilized to assess MKPV status in selected laboratory mice. MKPV was also detected in immunodeficient (NSG) and immunocompetent (Crl:CD1(ICR), UTX<sup>flox</sup>) mouse strains/stocks. The abundance of the MKPV genome copies was significantly correlated with the severity of IBN. Our data indicate that MKPV is present in selected mouse strains/stocks, and provides new insights into the genome evolution of MKPV.