cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.57760/sciencedb.07385
title: The cKIT kinase inhibitor CHMFL-KIT-64 was used in the treatment of gastrointestinal stromal tumors dataset
title: 针对cKIT激酶的抑制剂CHMFL-KIT-64用于治疗胃肠间质瘤数据集

description: Synthesis and characterization of compounds；Antiproliferative effects of compounds CHMFL-KIT-64 against a panel of c-KIT wt/c-KIT-T670I BaF3 cells；Selectivity profiling of compound CHMFL-KIT-64；Antiproliferation effects of compounds antiproliferation efects of compounds CHMFL-KIT-64 against a variety of GIST cancer cell lines；Cellular evaluation of compound CHMFL-KIT-64(for example cell cycle progression, apoptosis and signaling pathways);Antiproliferative effects of compounds CHMFL-KIT-64 against primary cells derived from GIST patients;In vivo PK/PD and efficacy evaluation of compound CHMFL-KIT-64;PK study of compound CHMFL-KIT-64 in mice, sprague dawley rats, and beagle dogs;Antitumor efficacy of CHMFL-KIT-64 in the BaF3-tel-c-KIT-T670I, BaF3-tel-c-KIT-D820G and BaF3-tel-c-KIT-Y823D xenograft mouse model.
description: Synthesis and characterization of compounds；Antiproliferative effects of compounds CHMFL-KIT-64 against a panel of c-KIT wt/c-KIT-T670I BaF3 cells；Selectivity profiling of compound CHMFL-KIT-64；Antiproliferation effects of compounds antiproliferation efects of compounds CHMFL-KIT-64 against a variety of GIST cancer cell lines；Cellular evaluation of compound CHMFL-KIT-64(for example cell cycle progression, apoptosis and signaling pathways);Antiproliferative effects of compounds CHMFL-KIT-64 against primary cells derived from GIST patients;In vivo PK/PD and efficacy evaluation of compound CHMFL-KIT-64;PK study of compound CHMFL-KIT-64 in mice, sprague dawley rats, and beagle dogs;Antitumor efficacy of CHMFL-KIT-64 in the BaF3-tel-c-KIT-T670I, BaF3-tel-c-KIT-D820G and BaF3-tel-c-KIT-Y823D xenograft mouse model.
DOI: 10.57760/sciencedb.05742
title: Study on Vector Radiative Transmission Characteristics of Polarization Optics in Underwater Bubble Environment-- Simulation data and experimental data sets
title: 水中气泡环境偏振光学矢量辐射传输特性研究-仿真数据与实验数据集

description: The data is composed of simulation original data and experimental original data
description: The data is composed of simulation original data and experimental original data
DOI: 10.57760/sciencedb.05743
title: a data set of the manucript :A high throughput plant regeneration of Sapium sebiferum
title: a data set of the manucript :A high throughput plant regeneration of Sapium sebiferum

description: A high-yielding tree (23-year-old) with red-type leaf was selected from a natural S. sebiferum population in Feidong County, Hefei City, Anhui Province, China, and served as the source for explants. The eﬀect of cytokinin, explant orientation, explant type as well as culture vessel type on adventitious shoots induction, themedium supple-mented with various concentrations (0.0, 0.1 or 0.5 mg l−1)of GA3 alone or in combination with 0.2 mg l-1 or 0.5 mg l-1 6-BA on shoot multiplication and elongation, the paramaters on rooting were studied .All the experiments were conducted in a completely randomized design. Every treatment was repeated three times, and each experiment contained at least 20 explants. The cultures were observed periodically and the statistical analysis was carried out using Origin 8.5 software. The data were processed by the analysis of variance (ANOVA) with Tukey’s test at P &lt; 0.05, and they were ﬁnally expressed as mean ± standard deviation (SD).
description: A high-yielding tree (23-year-old) with red-type leaf was selected from a natural S. sebiferum population in Feidong County, Hefei City, Anhui Province, China, and served as the source for explants. The eﬀect of cytokinin, explant orientation, explant type as well as culture vessel type on adventitious shoots induction, themedium supple-mented with various concentrations (0.0, 0.1 or 0.5 mg l−1)of GA3 alone or in combination with 0.2 mg l-1 or 0.5 mg l-1 6-BA on shoot multiplication and elongation, the paramaters on rooting were studied .All the experiments were conducted in a completely randomized design. Every treatment was repeated three times, and each experiment contained at least 20 explants. The cultures were observed periodically and the statistical analysis was carried out using Origin 8.5 software. The data were processed by the analysis of variance (ANOVA) with Tukey’s test at P &lt; 0.05, and they were ﬁnally expressed as mean ± standard deviation (SD).
DOI: 10.57760/sciencedb.05744
title: Characteristics of included studies in the meta-analysis
title: Characteristics of included studies in the meta-analysis

description: Supplemental Table 1. Characteristics of included studies in the meta-analysis
description: Supplemental Table 1. Characteristics of included studies in the meta-analysis
DOI: 10.57760/sciencedb.05747
title: A dataset of the paper:Efficient plant regeneration from in vitro leaves and petioles via shoot organogenesis in Sapium sebiferum Roxb.
title: A dataset of the paper:Efficient plant regeneration from in vitro leaves and petioles via shoot organogenesis in Sapium sebiferum Roxb.

description: In early June of 2018, healthy and fresh shoot stems (Fig. 1a) were collected from a 9-year-old high-yielding tree (S-51) with red autumn leaves growing at the Hefei Institutes of Physical Science, Chinese Academy of Sci-ences (N 31° 49′, E117° 13′).All experiments were conducted in a rand-omized complete block design (RCBD). Every treatment was repeated in three replicate experiments with at least 20 explants per treatment. The data were presented as the mean ± standard error (mean ± SE). All data were analyzed using ANOVA, and means were separated using Tukey’s test at P ≤ 0.05 (Origin 8.5, Origin Lab, USA).
description: In early June of 2018, healthy and fresh shoot stems (Fig. 1a) were collected from a 9-year-old high-yielding tree (S-51) with red autumn leaves growing at the Hefei Institutes of Physical Science, Chinese Academy of Sci-ences (N 31° 49′, E117° 13′).All experiments were conducted in a rand-omized complete block design (RCBD). Every treatment was repeated in three replicate experiments with at least 20 explants per treatment. The data were presented as the mean ± standard error (mean ± SE). All data were analyzed using ANOVA, and means were separated using Tukey’s test at P ≤ 0.05 (Origin 8.5, Origin Lab, USA).
DOI: 10.57760/sciencedb.05746
title: Osimertinib successfully combats EGFR-negative glioblastoma cells by inhibiting the MAPK pathway
title: Osimertinib successfully combats EGFR-negative glioblastoma cells by inhibiting the MAPK pathway

description: figure 2C,2D,2E,2G;Figure 3C;cell titer glotranscriptomic analysis
description: figure 2C,2D,2E,2G;Figure 3C;cell titer glotranscriptomic analysis
DOI: 10.57760/sciencedb.05748
title: A new approach for fault diagnosis with full-scope simulator based on state information imaging in nuclear power plant
title: A new approach for fault diagnosis with full-scope simulator based on state information imaging in nuclear power plant

description: In this paper, a new approach aimed at the Fault Diagnosis with Full-scope Simulator based on the StateInformation Imaging (FDFSSII) in NPP is proposed. The FDFSSII approach first constructs a series of grayimagewhich presents the operating transient (included normal and fault condition) according to the realtime monitoring data. Furthermore, the Machine Learning (ML) technology is employed to achieve imagefeature extraction and classification by analyzing and learning from massive amounts of historical andsynthetic gray-image data – the image feature is extracted by the Kernel Principal Component Analysis(KPCA) and classified by the designed classifiers in different learning methods. Finally, diagnosis effectis evaluated by the F1 score. The simulation result shows that the FDFSSII approach has achieved goodeffect for the fault diagnosis in NPP. Meanwhile, it simplifies the process of nuclear reactor with the largemonitoring data and provides useful support information to the operators.
description: In this paper, a new approach aimed at the Fault Diagnosis with Full-scope Simulator based on the StateInformation Imaging (FDFSSII) in NPP is proposed. The FDFSSII approach first constructs a series of grayimagewhich presents the operating transient (included normal and fault condition) according to the realtime monitoring data. Furthermore, the Machine Learning (ML) technology is employed to achieve imagefeature extraction and classification by analyzing and learning from massive amounts of historical andsynthetic gray-image data – the image feature is extracted by the Kernel Principal Component Analysis(KPCA) and classified by the designed classifiers in different learning methods. Finally, diagnosis effectis evaluated by the F1 score. The simulation result shows that the FDFSSII approach has achieved goodeffect for the fault diagnosis in NPP. Meanwhile, it simplifies the process of nuclear reactor with the largemonitoring data and provides useful support information to the operators.
DOI: 10.57760/sciencedb.05755
title: Articles-Pump fluences dependent hybrid nonlinearities in indium tin oxide films
title: 论文-Pump fluences dependent hybrid nonlinearities in indium tin oxide films

description: The raw data corresponding to the images in the paper -Pump fluences dependent hybrid nonlinearities in indium tin oxide films
description: The raw data corresponding to the images in the paper -Pump fluences dependent hybrid nonlinearities in indium tin oxide films
DOI: 10.57760/sciencedb.07383
title: Development of Gd-Si-O dispersed 316L stainless steel for improving neutron shielding performance
title: Development of Gd-Si-O dispersed 316L stainless steel for improving neutron shielding performance

description: Database of “Development of Gd-Si-O dispersed 316L stainless steel for improving neutron shielding performance”
description: Database of “Development of Gd-Si-O dispersed 316L stainless steel for improving neutron shielding performance”
DOI: 10.57760/sciencedb.05759
title: Targeting chaperon protein HSP70 as a novel therapeutic strategy for FLT3-ITD-positive acute myeloid leukemia
title: Targeting chaperon protein HSP70 as a novel therapeutic strategy for FLT3-ITD-positive acute myeloid leukemia

description: Western-blot;LC-MS and MS/MS for the identifification of QL47 modifification site in HSP70;mouse engraftment model;
description: Western-blot;LC-MS and MS/MS for the identifification of QL47 modifification site in HSP70;mouse engraftment model;
DOI: 10.57760/sciencedb.05761
title: Discovery of a Highly Selective VEGFR2 Kinase Inhibitor CHMFL-VEGFR2-002 as a Novel Anti-angiogenesis Agent
title: Discovery of a Highly Selective VEGFR2 Kinase Inhibitor CHMFL-VEGFR2-002 as a Novel Anti-angiogenesis Agent

description: Anti-proliferation activity of CHMFL-VEGFR2-002 in BaF3s cell linesPKs of CHMFL-VEGFR2-002 and sunitinibAcute toxicity test of CHMFL-VEGFR2-002 and sunitinibIntersegmental vessel (ISV) growthTranswell assaymouse xenograft model
description: Anti-proliferation activity of CHMFL-VEGFR2-002 in BaF3s cell linesPKs of CHMFL-VEGFR2-002 and sunitinibAcute toxicity test of CHMFL-VEGFR2-002 and sunitinibIntersegmental vessel (ISV) growthTranswell assaymouse xenograft model
DOI: 10.57760/sciencedb.07387
title: Electromagnetic Design and Mechanical Analysis of a 13-T Superconducting Magne
title: Electromagnetic Design and Mechanical Analysis of a 13-T Superconducting Magne

description: A 13-T superconducting magnet for Neutron Scattering Experiments was being developed at the High Magnetic Field Laboratory, Chinese Academy of Sciences, which will provide a high magnetic field environment to research condensed matter physics. It is made up of 6 Nb3Sn coils and 8 NbTi coils to provide a 13-T central magnetic field with 0.5% field inhomogeneity in the sample region of Ø10 mm×10 mm cylinder. Due to the horizontal opening angle of 320º and the vertical opening angle of ±8º, there is a very limited space for the support structure, which is expected to withstand an electromagnetic force of approximate 200 tons; as a result, the design of the support structure is crucial in order to avoid any harmful plastic deformation. In this paper, the electromagnetic solution, structure design, and mechanical analysis are mainly presented.
description: A 13-T superconducting magnet for Neutron Scattering Experiments was being developed at the High Magnetic Field Laboratory, Chinese Academy of Sciences, which will provide a high magnetic field environment to research condensed matter physics. It is made up of 6 Nb3Sn coils and 8 NbTi coils to provide a 13-T central magnetic field with 0.5% field inhomogeneity in the sample region of Ø10 mm×10 mm cylinder. Due to the horizontal opening angle of 320º and the vertical opening angle of ±8º, there is a very limited space for the support structure, which is expected to withstand an electromagnetic force of approximate 200 tons; as a result, the design of the support structure is crucial in order to avoid any harmful plastic deformation. In this paper, the electromagnetic solution, structure design, and mechanical analysis are mainly presented.
DOI: 10.57760/sciencedb.05764
title: Axitinib overcomes multiple imatinib resistant cKIT mutations including the gatekeeper mutation T670I in gastrointestinal stromal tumors
title: Axitinib overcomes multiple imatinib resistant cKIT mutations including the gatekeeper mutation T670I in gastrointestinal stromal tumors

description: Molecular modelingKinase biochemical assayColony formation assay Signaling pathway examinationApoptosis effect examinationallograft tumor modelsWhole transcriptome shotgun sequencing
description: Molecular modelingKinase biochemical assayColony formation assay Signaling pathway examinationApoptosis effect examinationallograft tumor modelsWhole transcriptome shotgun sequencing
DOI: 10.57760/sciencedb.05765
title: Hybrid Organic/PbS Quantum Dot Bilayer Photodetector with Low Dark Current and High Detectivity
title: Hybrid Organic/PbS Quantum Dot Bilayer Photodetector with Low Dark Current and High Detectivity

description: Owing to their ease of fabrication, low cost, and high flexibility, organic materials have attracted great interests in photodetector (PD) applications. However, suffering from large dark current, small photocurrent, low on–off ratio, and low sensitivity, performances of bare organic-based PDs are not satisfactory. Integrating organic materials with other novel semiconductor materials offers an opportunity to overcome these drawbacks. Here, a lateral hybrid organic/lead sulfide (PbS) quantum dot bilayer PD is designed and fabricated, which significantly suppresses the dark current and enhances the photocurrent, leading to improved light detecting capability. Meanwhile, the bilayer PD can be made on a flexible polyimide substrate.
description: Owing to their ease of fabrication, low cost, and high flexibility, organic materials have attracted great interests in photodetector (PD) applications. However, suffering from large dark current, small photocurrent, low on–off ratio, and low sensitivity, performances of bare organic-based PDs are not satisfactory. Integrating organic materials with other novel semiconductor materials offers an opportunity to overcome these drawbacks. Here, a lateral hybrid organic/lead sulfide (PbS) quantum dot bilayer PD is designed and fabricated, which significantly suppresses the dark current and enhances the photocurrent, leading to improved light detecting capability. Meanwhile, the bilayer PD can be made on a flexible polyimide substrate.
DOI: 10.57760/sciencedb.05767
title: Synthetic Antiferromagnets with Steplike Hysteresis Loops and High-T-C Based on All-Perovskite La0.7Sr0.3MnO3 Superlattices
title: Synthetic Antiferromagnets with Steplike Hysteresis Loops and High-T-C Based on All-Perovskite La0.7Sr0.3MnO3 Superlattices

description: Synthetic antiferromagnets with high Curie temperature (approximately 290 K) are realized among all-perovskite La0.7Sr0.3MnO3 (LSMO)/CaRu0.5Ti0.5O3 (CRTO) superlattices, which show antiferromagnetic (AF) interlayer exchange coupling (IEC) rather than traditional interfacial exchange coupling that is usually observed under the Curie temperature of the spacer. The system shows layer-resolved magnetic switching, resulting in sharp steplike hysteresis loops with magnetization plateaus depending on the repetition number of the stacking bilayers. This bilinear IEC can be easily changed to biquadratic IEC by change of orthorhombic NdGaO3(001) substrate to cubic (LaAlO3)(0.3)(SrAl0.5Ta0.5O3)(0.7)(001) substrate. The strength of AF IEC increases with decrease of temperature, and the modeling results suggest that both magnetic LSMO and the CRTO space layer play a role in this behavior. Remarkably, the LSMO/CRTO system shows controllability of AF-IEC behavior under a moderate magnetic field of hundreds of oersteds. These observations may have potential applications in future oxide spintronic devices.
description: Synthetic antiferromagnets with high Curie temperature (approximately 290 K) are realized among all-perovskite La0.7Sr0.3MnO3 (LSMO)/CaRu0.5Ti0.5O3 (CRTO) superlattices, which show antiferromagnetic (AF) interlayer exchange coupling (IEC) rather than traditional interfacial exchange coupling that is usually observed under the Curie temperature of the spacer. The system shows layer-resolved magnetic switching, resulting in sharp steplike hysteresis loops with magnetization plateaus depending on the repetition number of the stacking bilayers. This bilinear IEC can be easily changed to biquadratic IEC by change of orthorhombic NdGaO3(001) substrate to cubic (LaAlO3)(0.3)(SrAl0.5Ta0.5O3)(0.7)(001) substrate. The strength of AF IEC increases with decrease of temperature, and the modeling results suggest that both magnetic LSMO and the CRTO space layer play a role in this behavior. Remarkably, the LSMO/CRTO system shows controllability of AF-IEC behavior under a moderate magnetic field of hundreds of oersteds. These observations may have potential applications in future oxide spintronic devices.
DOI: 10.57760/sciencedb.05770
title: Anisotropic terahertz transmission induced by the external magnetic field in La0.67Ca0.33MnO3 film
title: Anisotropic terahertz transmission induced by the external magnetic field in La0.67Ca0.33MnO3 film

description: A systemic investigation of the terahertz (THz) transmission of La0.67Ca0.33MnO3 film on the (001)-oriented NdGaO3 substrate under external magnetic field and low temperature have been performed. The significant THz absorption difference between the out-of-plane and the in-plane magnetic field direction is observed, which is consistent with the electrical transport measurement using the standard four-probe technique. Furthermore, we find that the complex THz conductivities can be reproduced in terms of the Drude Smith equation as the magnetic field is perpendicular to the film plane, whereas it deviates from this model when the in-plane magnetic field is applied. We suggest that such anisotropies in THz transport dynamics have close correspondences with the phase separation and anisotropic magnetoresistance effects in the perovskite-structured manganites. Our work demonstrates that the THz time-domain spectroscopy (TDS) can be an effective non-contact method for studying the magneto-transport properties of the perovskite-structured manganites. (C) 2021 Author(s). All article content, except where otherwise noted, is licensed under a Creative Commons Attribution (CC BY) license
description: A systemic investigation of the terahertz (THz) transmission of La0.67Ca0.33MnO3 film on the (001)-oriented NdGaO3 substrate under external magnetic field and low temperature have been performed. The significant THz absorption difference between the out-of-plane and the in-plane magnetic field direction is observed, which is consistent with the electrical transport measurement using the standard four-probe technique. Furthermore, we find that the complex THz conductivities can be reproduced in terms of the Drude Smith equation as the magnetic field is perpendicular to the film plane, whereas it deviates from this model when the in-plane magnetic field is applied. We suggest that such anisotropies in THz transport dynamics have close correspondences with the phase separation and anisotropic magnetoresistance effects in the perovskite-structured manganites. Our work demonstrates that the THz time-domain spectroscopy (TDS) can be an effective non-contact method for studying the magneto-transport properties of the perovskite-structured manganites. (C) 2021 Author(s). All article content, except where otherwise noted, is licensed under a Creative Commons Attribution (CC BY) license
DOI: 10.57760/sciencedb.05773
title: Water movement and solute transport in deep vadose zone under four irrigated agricultural land-use types in the North China Plain
title: Water movement and solute transport in deep vadose zone under four irrigated agricultural land-use types in the North China Plain

description: Water movement and solute transport in deep vadose zone under four irrigated agricultural land-use types in the North China Plain
description: Water movement and solute transport in deep vadose zone under four irrigated agricultural land-use types in the North China Plain
DOI: 10.57760/sciencedb.05776
title: Discovery of (E)-N1-(3-fluorophenyl)-N3-(3-(2-(pyridin-2-yl)vinyl)-1Hindazol-6-yl)malonamide (CHMFL-KIT-033) as a Novel c-KIT T670I Mutant Selective Kinase Inhibitor for Gastrointestinal Stromal Tumors (GISTs)
title: Discovery of (E)-N1-(3-fluorophenyl)-N3-(3-(2-(pyridin-2-yl)vinyl)-1Hindazol-6-yl)malonamide (CHMFL-KIT-033) as a Novel c-KIT T670I Mutant Selective Kinase Inhibitor for Gastrointestinal Stromal Tumors (GISTs)

description: Biochemical Kinase AssayMolecular ModelingAntiproliferation AssaysSignaling Pathway StudyApoptosis Effect ExaminationRodent Pharmacokinetics.Xenograft Model
description: Biochemical Kinase AssayMolecular ModelingAntiproliferation AssaysSignaling Pathway StudyApoptosis Effect ExaminationRodent Pharmacokinetics.Xenograft Model
DOI: 10.57760/sciencedb.05779
title: DataSet of highway transport of spent fuel
title: 乏燃料公路运输事故条件下放射性核素弥散模型研究论文数据集

description: The data in the file related the tables and figures of the paper, which including:The compared data about with tree and without tree;The mesh indepent tests.
description: The data in the file related the tables and figures of the paper, which including:The compared data about with tree and without tree;The mesh indepent tests.