cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.7624241.v1
title: Supplementary Material for: Vascular Risk Factors and Findings on Brain MRI of Elderly Adult American Indians: The Strong Heart Study

description: <b><i>Background:</i></b> Clinical stroke is prevalent in American Indians, but the risk factors for cerebrovascular pathology have not been well-studied in this population. The purpose of this study was to correlate abnormalities on brain magnetic resonance imaging (MRI) with clinical risk factors in a cohort of elderly American Indians. <b><i>Methods:</i></b> Brain MRI scans from 789 participants of the Strong Heart Study were analyzed for infarcts, hemorrhage, white matter disease, and measures of cerebral atrophy including ventricular and sulcal grade and total brain volume. Clinical risk factors included measures of hypertension, diabetes, and high levels of low-density lipoprotein (LDL) cholesterol. Regression models adjusted for potential confounders were used to estimate associations between risk factors and brain MRI outcomes. <b><i>Results:</i></b> ­Hypertension was associated with the presence of infarcts (<i>p</i> = 0.001), ventricle enlargement (<i>p</i> = 0.01), and increased white matter hyperintensity volume (<i>p</i> = 0.01). Diabetes was associated with increased prevalence of cerebral atrophy (<i>p</i> &lt; 0.001), ventricular enlargement (<i>p</i> = 0.001), and sulcal widening (<i>p</i> = 0.001). High LDL was not significantly associated with any of the measured cranial imaging outcomes. <b><i>Conclusions:</i></b> This study found risk factors for cerebrovascular disease in American Indians similar to those seen in other populations and provides additional evidence for the important roles of hypertension and diabetes in promoting cerebral infarcts and brain atrophy, respectively.
DOI: 10.6084/m9.figshare.7624187
title: Supplementary Material for: Efficacy of a Novel Intranasal Formulation of Azelastine Hydrochloride and Fluticasone Propionate, Delivered in a Single Spray, for the Treatment of Seasonal Allergic Rhinitis: Results from Russia

description: <b><i>Background:</i></b> The novel intranasal formulation of azelastine hydrochloride (AZE) and fluticasone propionate (FP) in a single spray (MP-AzeFlu) was compared with a first-line intranasal antihistamine spray (AZE) in Russian seasonal allergic rhinitis (SAR) patients. <b><i>Methods:</i></b> Moderate-to-severe SAR/rhinoconjunctivitis patients (<i>n</i> = 149; aged 18–65 years) were randomized to receive MP-AzeFlu (137/50 μg AZE/FP per spray) or AZE (137 μg/spray), both as 1 spray/nostril twice daily, in a multicenter, open-label, 14-day, parallel-group trial. The primary outcome was change from baseline in morning and evening reflective total nasal symptom score (rTNSS). Secondary end points included: change from baseline in reflective total ocular symptom score (rTOSS), reflective total of 7 symptom scores (rT7SS), 28-item Rhinoconjunctivitis Quality of Life Questionnaire (RQLQ) overall score, and EuroQol-5D (EQ-5D) questionnaire score. <b><i>Results:</i></b> When compared with AZE-treated patients, those treated with MP-AzeFlu experienced significantly greater reductions in rTNSS (difference: –2.47; 95% confidence interval [CI] –3.65 to –1.30; <i>p</i> &lt; 0.001), rTOSS (difference: –1.62; 95% CI –2.32 to –0.92; <i>p</i> &lt; 0.001), and rT7SS (difference: –4.34; 95% CI –5.98 to –2.70; <i>p</i> &lt; 0.001). Superior relief observed on day 2 with MP-AzeFlu versus AZE was sustained throughout the study. MP-AzeFlu-treated patients experienced a greater improvement in QoL than AZE-treated patients as measured by overall RQLQ score (mean ± SD 2.91 ± 1.08 vs. 2.05 ± 1.15) and EQ-5D score (mean ± SD 87.4 ± 10.3 vs. 83.0 ± 12.8). MP-AzeFlu was well tolerated. <b><i>Conclusions:</i></b> MP-AzeFlu was superior to AZE in reducing moderate-to-severe SAR symptoms, providing earlier and more complete symptom relief.
DOI: 10.7284/113831
title: GNSS (Global Navigation Satellite System) data collected during research cruise EN535 using a Northstar 952 instrument system onboard the platform RV Endeavor

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7624187.v1
title: Supplementary Material for: Efficacy of a Novel Intranasal Formulation of Azelastine Hydrochloride and Fluticasone Propionate, Delivered in a Single Spray, for the Treatment of Seasonal Allergic Rhinitis: Results from Russia

description: <b><i>Background:</i></b> The novel intranasal formulation of azelastine hydrochloride (AZE) and fluticasone propionate (FP) in a single spray (MP-AzeFlu) was compared with a first-line intranasal antihistamine spray (AZE) in Russian seasonal allergic rhinitis (SAR) patients. <b><i>Methods:</i></b> Moderate-to-severe SAR/rhinoconjunctivitis patients (<i>n</i> = 149; aged 18–65 years) were randomized to receive MP-AzeFlu (137/50 μg AZE/FP per spray) or AZE (137 μg/spray), both as 1 spray/nostril twice daily, in a multicenter, open-label, 14-day, parallel-group trial. The primary outcome was change from baseline in morning and evening reflective total nasal symptom score (rTNSS). Secondary end points included: change from baseline in reflective total ocular symptom score (rTOSS), reflective total of 7 symptom scores (rT7SS), 28-item Rhinoconjunctivitis Quality of Life Questionnaire (RQLQ) overall score, and EuroQol-5D (EQ-5D) questionnaire score. <b><i>Results:</i></b> When compared with AZE-treated patients, those treated with MP-AzeFlu experienced significantly greater reductions in rTNSS (difference: –2.47; 95% confidence interval [CI] –3.65 to –1.30; <i>p</i> &lt; 0.001), rTOSS (difference: –1.62; 95% CI –2.32 to –0.92; <i>p</i> &lt; 0.001), and rT7SS (difference: –4.34; 95% CI –5.98 to –2.70; <i>p</i> &lt; 0.001). Superior relief observed on day 2 with MP-AzeFlu versus AZE was sustained throughout the study. MP-AzeFlu-treated patients experienced a greater improvement in QoL than AZE-treated patients as measured by overall RQLQ score (mean ± SD 2.91 ± 1.08 vs. 2.05 ± 1.15) and EQ-5D score (mean ± SD 87.4 ± 10.3 vs. 83.0 ± 12.8). MP-AzeFlu was well tolerated. <b><i>Conclusions:</i></b> MP-AzeFlu was superior to AZE in reducing moderate-to-severe SAR symptoms, providing earlier and more complete symptom relief.
DOI: 10.7284/113833
title: Gyrocompass data collected during research cruise EN535 using a Sperry MK-37 instrument system onboard the platform RV Endeavor

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/113834
title: Gyrocompass data collected during research cruise EN535 using a Sperry MK-37 instrument system onboard the platform RV Endeavor

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/113836
title: Speedlog data collected during research cruise EN535 using a EDO MRQ-4015D instrument system onboard the platform RV Endeavor

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/113835
title: TSG (Thermosalinograph) data collected during research cruise EN535 using a Sea-Bird SBE-45 instrument system onboard the platform RV Endeavor

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7624001
title: Uncropped Western blots for Tubulin, Albumin, Transferrin, AFP and C/EBPbeta (https://doi.org/10.1371/journal.pone.0013650)

description: Uncropped Western blot for Tubulin.
DOI: 10.6084/m9.figshare.7624010
title: Supplementary Material for: Trauma Disclosure Moderates the Effects of Oxytocin on Intrusions and Neural Responses to Fear

description: Medicine
DOI: 10.6084/m9.figshare.7623983
title: Intracameral Phenylephrine to Arrest Intraoperative Intraocular Bleeding

description: Full copyright for enhanced digital features is owned by the authors. <strong>Article full text</strong> <br> The full text of this article can be found <b>here</b>. <br> <br> <strong>Provide enhanced digital features for this article</strong><br> If you are an author of this publication and would like to provide additional enhanced digital features for your article then please contact adisrapidplus@springer.com.<br> <br> The journal offers a range of additional features designed to increase visibility and readership. All features will be thoroughly peer reviewed to ensure the content is of the highest scientific standard and all features are marked as ‘peer reviewed’ to ensure readers are aware that the content has been reviewed to the same level as the articles they are being presented alongside. Moreover, all sponsorship and disclosure information is included to provide complete transparency and adherence to good publication practices. This ensures that however the content is reached the reader has a full understanding of its origin. No fees are charged for hosting additional open access content.<br> <br> Other enhanced features include, but are not limited to:<br> • Slide decks<br> • Videos and animations<br> • Audio abstracts<br> • Audio slides
DOI: 10.7284/113837
title: TSG (Thermosalinograph) data collected during research cruise EN535 using a Sea-Bird SBE-21 instrument system onboard the platform RV Endeavor

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7623977
title: microbiota data

description: microibota data
DOI: 10.6084/m9.figshare.7623977.v1
title: microbiota data

description: microibota data
DOI: 10.6084/m9.figshare.7623983.v1
title: Intracameral Phenylephrine to Arrest Intraoperative Intraocular Bleeding

description: Full copyright for enhanced digital features is owned by the authors. <strong>Article full text</strong> <br> The full text of this article can be found <b>here</b>. <br> <br> <strong>Provide enhanced digital features for this article</strong><br> If you are an author of this publication and would like to provide additional enhanced digital features for your article then please contact adisrapidplus@springer.com.<br> <br> The journal offers a range of additional features designed to increase visibility and readership. All features will be thoroughly peer reviewed to ensure the content is of the highest scientific standard and all features are marked as ‘peer reviewed’ to ensure readers are aware that the content has been reviewed to the same level as the articles they are being presented alongside. Moreover, all sponsorship and disclosure information is included to provide complete transparency and adherence to good publication practices. This ensures that however the content is reached the reader has a full understanding of its origin. No fees are charged for hosting additional open access content.<br> <br> Other enhanced features include, but are not limited to:<br> • Slide decks<br> • Videos and animations<br> • Audio abstracts<br> • Audio slides
DOI: 10.7284/113839
title: GNSS (Global Navigation Satellite System) data collected during research cruise EN536 using a Furuno GP-90D instrument system onboard the platform RV Endeavor
DOI: 10.6084/m9.figshare.7623953
title: Plots source data

description: Contains the data necessary for the plots of the figures of the article.<br>
DOI: 10.7284/113840
title: GNSS (Global Navigation Satellite System) data collected during research cruise EN536 using a Northstar 952 instrument system onboard the platform RV Endeavor

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7623938
title: Transthyretin deposition in the eye in the era of effective therapy for hereditary ATTRV30M amyloidosis

description: <b>Background:</b> Ocular abnormalities have been known to occur in hereditary amyloidotic polyneuropathy since the 1950s. While vitreous opacities and scalloped pupils were described early it has become evident that every component of the eye from the conjunctiva to the retinal vasculature can be involved. Reports from the major centres in Japan, Portugal and Sweden, which primarily treat patients with ATTRV30M, have indicated that with the increased longevity seen in patients treated with liver transplantation the frequency of the more severe eye findings, notably vitreous opacities and subsequent glaucoma, are being detected more frequently. <b>Methods:</b> In an attempt to confirm that the experience was similar in a broader range of locales we performed a survey of ten treatment centres in eight countries to determine the frequency of severe ocular abnormalities (vitreous opacities and glaucoma) in 804 patients with V30M disease and whether there was any relationship to treatment with liver transplantation or the transthyretin stabilizer tafamidis. <b>Results:</b> The data indicate that the frequency of these abnormalities increases with increasing duration of disease. In patients broadly matched for duration of disease the frequency was higher in subjects who had undergone liver transplantation than in those who were untreated. <b>Conclusions:</b> Retrospective surveys are subject to a number of potential biases. In this case, the major potential confounders were defining the time of disease onset and physician bias in choice of therapy, particularly regarding the choice of patients and the time in their course when they should undergo liver transplantation, and when and whether they should receive tafamidis. Nonetheless it appears that the incidence of severe ocular abnormalities in V30M subjects from centres around the world is similar to those found in centres in the areas endemic for this variant protein. The incidence increased with duration of disease regardless of therapy with the highest frequencies seen in patients more than ten years after diagnosis who had undergone liver transplantation.
DOI: 10.6084/m9.figshare.7623911
title: Networks

description: Network bla bla bla bla
DOI: 10.7284/113847
title: GNSS (Global Navigation Satellite System) data collected during research cruise EN536 using a Trimble NT-300D instrument system onboard the platform RV Endeavor
DOI: 10.6084/m9.figshare.7623938.v2
title: Transthyretin deposition in the eye in the era of effective therapy for hereditary ATTRV30M amyloidosis

description: <b>Background:</b> Ocular abnormalities have been known to occur in hereditary amyloidotic polyneuropathy since the 1950s. While vitreous opacities and scalloped pupils were described early it has become evident that every component of the eye from the conjunctiva to the retinal vasculature can be involved. Reports from the major centres in Japan, Portugal and Sweden, which primarily treat patients with ATTRV30M, have indicated that with the increased longevity seen in patients treated with liver transplantation the frequency of the more severe eye findings, notably vitreous opacities and subsequent glaucoma, are being detected more frequently. <b>Methods:</b> In an attempt to confirm that the experience was similar in a broader range of locales we performed a survey of ten treatment centres in eight countries to determine the frequency of severe ocular abnormalities (vitreous opacities and glaucoma) in 804 patients with V30M disease and whether there was any relationship to treatment with liver transplantation or the transthyretin stabilizer tafamidis. <b>Results:</b> The data indicate that the frequency of these abnormalities increases with increasing duration of disease. In patients broadly matched for duration of disease the frequency was higher in subjects who had undergone liver transplantation than in those who were untreated. <b>Conclusions:</b> Retrospective surveys are subject to a number of potential biases. In this case, the major potential confounders were defining the time of disease onset and physician bias in choice of therapy, particularly regarding the choice of patients and the time in their course when they should undergo liver transplantation, and when and whether they should receive tafamidis. Nonetheless it appears that the incidence of severe ocular abnormalities in V30M subjects from centres around the world is similar to those found in centres in the areas endemic for this variant protein. The incidence increased with duration of disease regardless of therapy with the highest frequencies seen in patients more than ten years after diagnosis who had undergone liver transplantation.
DOI: 10.6084/m9.figshare.7623911.v1
title: Networks

description: Network bla bla bla bla
DOI: 10.7284/113844
title: Speedlog data collected during research cruise EN536 using a EDO MRQ-4015D instrument system onboard the platform RV Endeavor

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7623854
title: Variability of functional traits and their syndromes in a freshwater fish species (Phoxinus phoxinus): The role of adaptive and non‐adaptive processes

description: Functional traits can covary to form “functional syndromes.” Describing and understanding functional syndromes is an important prerequisite for predicting the effects of organisms on ecosystem functioning. At the intraspecific level, functional syndromes have recently been described, but very little is known about their variability among populations and—if they vary—what the ecological and evolutionary drivers of this variation are. Here, we quantified and compared the variability in four functional traits (body mass, metabolic rate, excretion rate, and boldness), their covariations and the subsequent syndromes among thirteen populations of a common freshwater fish (the European minnow, Phoxinus phoxinus). We then tested whether functional traits and their covariations, as well as the subsequent syndromes, were underpinned by the phylogenetic relatedness among populations (historical effects) or the local environment (i.e., temperature and predation pressure), and whether adaptive (selection or plasticity) or non‐adaptive (genetic drift) processes sustained among‐population variability. We found substantial among‐population variability in functional traits and trait covariations and in the emerging syndromes. We further found that adaptive mechanisms (plasticity and/or selection) related to water temperature and predation pressure modulated the covariation between body mass and metabolic rate. Other trait covariations were more likely driven by genetic drift, suggesting that non‐adaptive processes can also lead to substantial differences in trait covariations among populations. Overall, we concluded that functional syndromes are population‐specific, and that both adaptive and non‐adaptive processes are shaping functional traits. Given the pivotal role of functional traits, differences in functional syndromes within species provide interesting perspectives regarding the role of intraspecific diversity for ecosystem functioning.
DOI: 10.7284/113851
title: ADCP (Acoustic Doppler Current Profiler) data collected during research cruise EN537 using a Hawaii UHDAS instrument system onboard the platform RV Endeavor

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7623836
title: TableS5_PCA

description: Association with development of GDM and and variable importance index provided by random forest analysis.<br>
DOI: 10.6084/m9.figshare.7623836.v1
title: TableS5_PCA

description: Association with development of GDM and and variable importance index provided by random forest analysis.<br>
DOI: 10.6084/m9.figshare.7623854.v1
title: Variability of functional traits and their syndromes in a freshwater fish species (Phoxinus phoxinus): The role of adaptive and non‐adaptive processes

description: Functional traits can covary to form “functional syndromes.” Describing and understanding functional syndromes is an important prerequisite for predicting the effects of organisms on ecosystem functioning. At the intraspecific level, functional syndromes have recently been described, but very little is known about their variability among populations and—if they vary—what the ecological and evolutionary drivers of this variation are. Here, we quantified and compared the variability in four functional traits (body mass, metabolic rate, excretion rate, and boldness), their covariations and the subsequent syndromes among thirteen populations of a common freshwater fish (the European minnow, Phoxinus phoxinus). We then tested whether functional traits and their covariations, as well as the subsequent syndromes, were underpinned by the phylogenetic relatedness among populations (historical effects) or the local environment (i.e., temperature and predation pressure), and whether adaptive (selection or plasticity) or non‐adaptive (genetic drift) processes sustained among‐population variability. We found substantial among‐population variability in functional traits and trait covariations and in the emerging syndromes. We further found that adaptive mechanisms (plasticity and/or selection) related to water temperature and predation pressure modulated the covariation between body mass and metabolic rate. Other trait covariations were more likely driven by genetic drift, suggesting that non‐adaptive processes can also lead to substantial differences in trait covariations among populations. Overall, we concluded that functional syndromes are population‐specific, and that both adaptive and non‐adaptive processes are shaping functional traits. Given the pivotal role of functional traits, differences in functional syndromes within species provide interesting perspectives regarding the role of intraspecific diversity for ecosystem functioning.
DOI: 10.6084/m9.figshare.7623824
title: TableS3_PCA

description: Correlation of the principal component scores (PCS) with glucometabolic parameters at 24+0 to 28+6.<br>
DOI: 10.6084/m9.figshare.7623827
title: TableS4_PCA

description: Correlation of the principal component scores (PCS) with glucometabolic parameters at 2 to 11 months after delivery.<br>
DOI: 10.7284/113850
title: CTD (Conductivity, Temperature, Depth) data collected during research cruise EN537 using a Sea-Bird SBE-911+ instrument system onboard the platform RV Endeavor

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7623824.v1
title: TableS3_PCA

description: Correlation of the principal component scores (PCS) with glucometabolic parameters at 24+0 to 28+6.<br>
DOI: 10.6084/m9.figshare.7623827.v1
title: TableS4_PCA

description: Correlation of the principal component scores (PCS) with glucometabolic parameters at 2 to 11 months after delivery.<br>
DOI: 10.6084/m9.figshare.7623812
title: TableS2_PCA

description: Correlation of the principal component scores (PCS) with glucometabolic parameters at 12+0 to 22+6.<br>
DOI: 10.6084/m9.figshare.7623812.v1
title: TableS2_PCA

description: Correlation of the principal component scores (PCS) with glucometabolic parameters at 12+0 to 22+6.<br>
DOI: 10.7284/113857
title: Fluorometer data collected during research cruise EN537 using a Turner 10-AU instrument system onboard the platform RV Endeavor

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7623800
title: TableS1_PCA

description: Loadings of each variable on the first three components. <br>
DOI: 10.6084/m9.figshare.7623779
title: How do faults grow above dykes? Data Videos

description: Videos showing a playthrough of seismic reflection data imaging dykes and overlying dyke-induced normal faults. The 3D volume shown is part of the Chandon 3D seismic survey, located on the Exmouth Plateau offshore NW Australia, available from Geoscience Australia at http://www.ga.gov.au/nopims. In the 'Dyke & Fault Reveal Video', line interpretations shown: red = dykes; black = dyke-induced normal faults; white = tectonic faults. The 'Surfaces 3D' video reveals the local 3D interpretations of two dyke-induced normal faults, with one having a blue (high dip) to white (low dip) scale corresponding to fault dip whilst the other shows variations in fault displacement (high displacement = warm colours; low displacement = black and grey). Also shown are the mapped Top Mungaroo surface (near Top Triassic) and vertical dyke. The 'Surfaces 3D extended' video was added at a later date but shows the same, this time including a legend, as the 'Surfaces 3D' video.