cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.7850972
title: A novel circular RNA, hsa_circ_0043278, acts as a potential biomarker and promotes non-small cell lung cancer cell proliferation and migration by regulating miR-520f

description: More and more circular RNAs (circRNAs) revealed to play a critical role in the initiation and progression of cancer, however, the effects of circRNAs on non-small cell lung cancer (NSCLC) remain largely undetermined. In the present study, we screened the dysregulated circRNAs in paired NSCLC and normal samples from GEO database and identified circ_0043278 was to be significantly up-regulated in NSCLC and demonstrated it promotes NSCLC progression <i>in vitro</i> and <i>in vivo</i>. Then, we revealed the expression of miR-520f, a downstream factor of circ_0043278, was significantly down-regulated in NSCLC and acted as a tumor inhibitor. In addition, we revealed that circ_0043278 sponged miR-520f, which was demonstrated to target ROCK1, CDKN1B, and AKT3 in NSCLC cells. In conclusion, circ_0043278 promoted NSCLC cell proliferation, invasion, and migration by increasing ROCK1, CDKN1B, and AKT3 expressions through direct inhibition of miR-520f.
DOI: 10.6084/m9.figshare.7850972.v1
title: A novel circular RNA, hsa_circ_0043278, acts as a potential biomarker and promotes non-small cell lung cancer cell proliferation and migration by regulating miR-520f

description: More and more circular RNAs (circRNAs) revealed to play a critical role in the initiation and progression of cancer, however, the effects of circRNAs on non-small cell lung cancer (NSCLC) remain largely undetermined. In the present study, we screened the dysregulated circRNAs in paired NSCLC and normal samples from GEO database and identified circ_0043278 was to be significantly up-regulated in NSCLC and demonstrated it promotes NSCLC progression <i>in vitro</i> and <i>in vivo</i>. Then, we revealed the expression of miR-520f, a downstream factor of circ_0043278, was significantly down-regulated in NSCLC and acted as a tumor inhibitor. In addition, we revealed that circ_0043278 sponged miR-520f, which was demonstrated to target ROCK1, CDKN1B, and AKT3 in NSCLC cells. In conclusion, circ_0043278 promoted NSCLC cell proliferation, invasion, and migration by increasing ROCK1, CDKN1B, and AKT3 expressions through direct inhibition of miR-520f.
DOI: 10.13018/bmr28124
title: 5-Hydroxytryptophan-containing peptide for random coil chemical shifts at pH 2.3 and 7.4
DOI: 10.15468/dl.bgs2kp
title: Occurrence Download

description: A dataset containing 59 species occurrences available in GBIF matching the query:
{
 "and" : [
 "HasGeospatialIssue is false",
 "HasCoordinate is true",
 "OccurrenceStatus is Present",
 {
 "not" : {
 "BasisOfRecord" : [
 "is one of (Fossil, Living Specimen)"
 ]
 }
 },
 "TaxonKey is one of (Valencia letourneuxi)",
 "Geometry POLYGON((19.0 42.0, 19.0 34.5, 29.7 34.5, 29.7 42.0, 19.0 42.0))"
 ]
}

 The dataset includes 59 records from 7 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0003491-260225131425191/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.13018/bmr28125
title: Kynurenine-containing peptide for random coil chemical shifts at pH 2.3 and 7.4
DOI: 10.6084/m9.figshare.8300024
title: Delivery of mesenchymal stem cells-derived extracellular vesicles with enriched miR-185 inhibits progression of OPMD

description: Oral leukoplakia is one of the most common oral potentially malignant disorders (OPMDs) and its malignant transformation to oral cancer is highly associated with chronic inflammation. Extracellular vesicles (EVs) or exosome-delivered microRNAs modulate inflammatory responses and alleviate irritations that predisposes to cancer. We previously reported that microRNA-185 (miR-185) was significantly decreased in the buccal tissue of patients with oral cancer. In this study, we utilized genetically modified mesenchymal stem cells (MSCs) derived EVs with high expression of miR-185 to pasted MSC-EV-miR-185 on buccal lesions in dimethylbenzanthracene (DMBA) induced OPMD model. We found that treatment with MSC-EV-miR-185 remarkably attenuated inflammation severity and significantly decreased the incidence and the number of dysplasia in the OPMD tissue. Immunohistochemistry showed significantly decreased expression of proliferation marker PCNA and angiogenic marker CD31 in the lesion treated with MSC-EV-miR-185. Furthermore, miR-185 specifically targeted Akt genes by promoting activation of the apoptotic pathway, confirmed by the increased levels of activated caspase-3 and 9. In conclusion, genetically modified MSC-derived EVs enriched with miR-185 alleviate inflammatory response, inhibit cell proliferation and angiogenesis, and induce cell apoptosis, suggesting that their potential role as a novel therapeutic option for OPMD.
DOI: 10.6084/m9.figshare.8300024.v1
title: Delivery of mesenchymal stem cells-derived extracellular vesicles with enriched miR-185 inhibits progression of OPMD

description: Oral leukoplakia is one of the most common oral potentially malignant disorders (OPMDs) and its malignant transformation to oral cancer is highly associated with chronic inflammation. Extracellular vesicles (EVs) or exosome-delivered microRNAs modulate inflammatory responses and alleviate irritations that predisposes to cancer. We previously reported that microRNA-185 (miR-185) was significantly decreased in the buccal tissue of patients with oral cancer. In this study, we utilized genetically modified mesenchymal stem cells (MSCs) derived EVs with high expression of miR-185 to pasted MSC-EV-miR-185 on buccal lesions in dimethylbenzanthracene (DMBA) induced OPMD model. We found that treatment with MSC-EV-miR-185 remarkably attenuated inflammation severity and significantly decreased the incidence and the number of dysplasia in the OPMD tissue. Immunohistochemistry showed significantly decreased expression of proliferation marker PCNA and angiogenic marker CD31 in the lesion treated with MSC-EV-miR-185. Furthermore, miR-185 specifically targeted Akt genes by promoting activation of the apoptotic pathway, confirmed by the increased levels of activated caspase-3 and 9. In conclusion, genetically modified MSC-derived EVs enriched with miR-185 alleviate inflammatory response, inhibit cell proliferation and angiogenesis, and induce cell apoptosis, suggesting that their potential role as a novel therapeutic option for OPMD.
DOI: 10.13018/bmr28126
title: Methionine sulfoxide-containing peptide for random coil chemical shifts at pH 2.3 and 7.4 (with Ala as succeeding residue)
DOI: 10.6084/m9.figshare.8052740
title: MicroRNA-10b controls the metastasis and proliferation of colorectal cancer cells by regulating Krüppel-like factor 4

description: Mir-10b has been reported as a key regulator of metastasis in many human tumours. Moreover, it has also been regarded as a prognostic marker and therapeutic target of colorectal cancer (CRC). Whether miR-10b could affect the metastasis and proliferation of CRC is unclear. MiR-10b expression was detected by qPCR in human CRC tissues and cell line, Luciferase activity was employed for miR-10b binding to the 3`UTR of KLF4, Genes expression were examined by western blot, and mRNA by qPCR. PI and Annexin V staining were used to evaluate the cell cycle and apoptosis. Cell proliferation was detected with MTT, and cell migration and invasion were performed with Transwell assay. We found that miR-10b expression was up-regulated in metastatic CRC tissues and cell lines. Inhibition of miR-10b prevented cancer cell metastasis and growth by inducing cell-cycle arrest and apoptosis <i>in vitro</i>. Moreover, we found that KLF4 was a direct target of miR-10b. MiR-10b inhibitor led to the up-regulation of E-cadherin expression and the down-regulation of cyclin D1, which were partly abrogated after silencing KLF4.
DOI: 10.6084/m9.figshare.8052740.v1
title: MicroRNA-10b controls the metastasis and proliferation of colorectal cancer cells by regulating Krüppel-like factor 4

description: Mir-10b has been reported as a key regulator of metastasis in many human tumours. Moreover, it has also been regarded as a prognostic marker and therapeutic target of colorectal cancer (CRC). Whether miR-10b could affect the metastasis and proliferation of CRC is unclear. MiR-10b expression was detected by qPCR in human CRC tissues and cell line, Luciferase activity was employed for miR-10b binding to the 3`UTR of KLF4, Genes expression were examined by western blot, and mRNA by qPCR. PI and Annexin V staining were used to evaluate the cell cycle and apoptosis. Cell proliferation was detected with MTT, and cell migration and invasion were performed with Transwell assay. We found that miR-10b expression was up-regulated in metastatic CRC tissues and cell lines. Inhibition of miR-10b prevented cancer cell metastasis and growth by inducing cell-cycle arrest and apoptosis <i>in vitro</i>. Moreover, we found that KLF4 was a direct target of miR-10b. MiR-10b inhibitor led to the up-regulation of E-cadherin expression and the down-regulation of cyclin D1, which were partly abrogated after silencing KLF4.
DOI: 10.6084/m9.figshare.10248905.v1
title: MiR-199a-5p regulates rat liver regeneration and hepatocyte proliferation by targeting TNF-α TNFR1/TRADD/CASPASE8/CASPASE3 signalling pathway

description: Abnormally expressed miR-199a-5p (miR-199a) has been frequently reported in multiple types of malignancies. Nevertheless, its effect in liver regeneration (LR) is largely still unclear. Herein, we investigated the function of miR-199a in hepatocyte proliferation during LR. As a result, miR-199a expression was significantly increased 12–30 h, in rat hepatic tissue, after partial hepatectomy (PH). The down-regulated expression of miR-199a inhibited proliferation as well as promoted cell apoptosis of BRL-3A. Additionally, TNF-α was found as a target of miR-199a. The administration of TNF-α siRNA regulated the effects of miR-199a on hepatocyte proliferation as well as miR-199a-modulated TNF-α/TNFR1/TRADD/CASPASE8/CASPASE3 signalling pathways. Taken together, these present findings suggested that miR-199a promoted hepatocyte proliferation as well as LR via targeting TNF-α/TNFR1/TRADD/CASPASE8/CASPASE3.
DOI: 10.13018/bmr28127
title: Methionine sulfoxide-containing peptide for random coil chemical shifts at pH 2.3 and 7.4 (with Pro as succeeding residue)
DOI: 10.6084/m9.figshare.10248905
title: MiR-199a-5p regulates rat liver regeneration and hepatocyte proliferation by targeting TNF-α TNFR1/TRADD/CASPASE8/CASPASE3 signalling pathway

description: Abnormally expressed miR-199a-5p (miR-199a) has been frequently reported in multiple types of malignancies. Nevertheless, its effect in liver regeneration (LR) is largely still unclear. Herein, we investigated the function of miR-199a in hepatocyte proliferation during LR. As a result, miR-199a expression was significantly increased 12–30 h, in rat hepatic tissue, after partial hepatectomy (PH). The down-regulated expression of miR-199a inhibited proliferation as well as promoted cell apoptosis of BRL-3A. Additionally, TNF-α was found as a target of miR-199a. The administration of TNF-α siRNA regulated the effects of miR-199a on hepatocyte proliferation as well as miR-199a-modulated TNF-α/TNFR1/TRADD/CASPASE8/CASPASE3 signalling pathways. Taken together, these present findings suggested that miR-199a promoted hepatocyte proliferation as well as LR via targeting TNF-α/TNFR1/TRADD/CASPASE8/CASPASE3.
DOI: 10.13018/bmr28128
title: Methionine sulfone-containing peptide for random coil chemical shifts at pH 2.3 and 7.4
DOI: 10.6084/m9.figshare.8948822
title: Large-scale quantitative genomics analyzes the circRNA expression profile and identifies the key circRNA in regulating cell proliferation during the proliferation phase of rat LR

description: Researchers have been exploring the genetic mechanisms underlying the control of liver regeneration (LR). However, an integrated analysis of circRNAs expression of rat regenerating livers during the proliferation phase has not been performed yet. For this purpose, circRNAs expression profile was globally analyzed by high-throughput sequencing. It showed that 10,003 circRNAs were detected, and 164 circRNAs were differentially expressed. Subsequently, 27 circRNAs were predicted to bind to 58 candidate miRNAs and compete for miRNA-binding sites with 2195 mRNAs. By applying GO and KEGG analysis, it was predicted that these circRNAs significantly participated in tissue regeneration, regulation of cell proliferation and Ras, p53, Wnt, Jak-STAT, MAPK signalling pathways. Based on the number of the corresponding miRNAs and their role enriched and reported in cell proliferation of LR or hepatocellular carcinoma, four kinds of circRNAs (circ_03848, circ_08236, circ_13398 and circ_15013) were considered as the key circRNAs. The predicted competing endogenous RNA networks and bioinformatics analysis revealed the potential role of these circRNAs in LR, which would provide useful information for understanding the mechanism of LR.
DOI: 10.6084/m9.figshare.8948822.v1
title: Large-scale quantitative genomics analyzes the circRNA expression profile and identifies the key circRNA in regulating cell proliferation during the proliferation phase of rat LR

description: Researchers have been exploring the genetic mechanisms underlying the control of liver regeneration (LR). However, an integrated analysis of circRNAs expression of rat regenerating livers during the proliferation phase has not been performed yet. For this purpose, circRNAs expression profile was globally analyzed by high-throughput sequencing. It showed that 10,003 circRNAs were detected, and 164 circRNAs were differentially expressed. Subsequently, 27 circRNAs were predicted to bind to 58 candidate miRNAs and compete for miRNA-binding sites with 2195 mRNAs. By applying GO and KEGG analysis, it was predicted that these circRNAs significantly participated in tissue regeneration, regulation of cell proliferation and Ras, p53, Wnt, Jak-STAT, MAPK signalling pathways. Based on the number of the corresponding miRNAs and their role enriched and reported in cell proliferation of LR or hepatocellular carcinoma, four kinds of circRNAs (circ_03848, circ_08236, circ_13398 and circ_15013) were considered as the key circRNAs. The predicted competing endogenous RNA networks and bioinformatics analysis revealed the potential role of these circRNAs in LR, which would provide useful information for understanding the mechanism of LR.
DOI: 10.13018/bmr28129
title: N-formylkynurenine-containing peptide for random coil chemical shifts at pH 2.3 and 7.4
DOI: 10.5281/zenodo.18786782
title: PHILOSOPHICAL VIEWS IN IRIS MURDOCH'S NOVEL THE BLACK PRINCE

description: This article examines the philosophical views presented in Iris Murdoch’s novel The Black Prince. In these works, creativity is understood not merely as an aesthetic or imaginative activity, but as a means of achieving moral awakening through the purification of the inner self and the transcendence of the limits of egoism. While reading the novel, the reader witnesses a realistic portrayal of the characters, revealed through their flaws and psychological complexities.
DOI: 10.5281/zenodo.18786781
title: PHILOSOPHICAL VIEWS IN IRIS MURDOCH'S NOVEL THE BLACK PRINCE

description: This article examines the philosophical views presented in Iris Murdoch’s novel The Black Prince. In these works, creativity is understood not merely as an aesthetic or imaginative activity, but as a means of achieving moral awakening through the purification of the inner self and the transcendence of the limits of egoism. While reading the novel, the reader witnesses a realistic portrayal of the characters, revealed through their flaws and psychological complexities.
DOI: 10.13018/bmr28130
title: Oxindolylalanine-containing peptide for random coil chemical shifts at pH 2.3 and 7.4
DOI: 10.15468/dl.kguxft
title: Occurrence Download

description: A dataset containing 2327 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Mesocentrotus franciscanus",
 "DecimalLongitude is greater than or equal to -162",
 "DecimalLongitude is less than or equal to -121",
 "DecimalLatitude is greater than or equal to 44",
 "DecimalLatitude is less than or equal to 64",
 "HasCoordinate is true"
 ]
}

 The dataset includes 2327 records from 27 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0003492-260225131425191/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.13018/bmr28131
title: 1H 15N 13C Resonance Assignments of Receptor Binding Domain 2 of CDTb (757-876)
DOI: 10.13018/bmr28132
title: Backbone and side chain 1H, 15N, 13C chemical shift assignments and kinetic datas of polyketide cyclase [Mycobacterium tuberculosis]
DOI: 10.6084/m9.figshare.7618529
title: MiR-30a-5p frequently downregulated in prostate cancer inhibits cell proliferation via targeting PCLAF

description: MicroRNAs (miRNAs) have vastly expanded our view of RNA world in intracellular signal regulating networks. Here, we functionally characterized a normally highly expressed miRNA, miR-30a-5p (MIMAT0000087), which exhibits downregulated expression profiles in prostate cancer samples. MiR-30a-5p knockdown and overexpression in PC-3 cell line alters cell proliferation supporting a tumour suppressor role. We also discovered that PCLAF is the direct target of miR-30a-5p. Notably, PC-3 cell proliferation is inhibited by miR-30a-5p/PCLAF axis. miR-30a-5p represents a novel molecule of functionally important miRNAs which may shed light on the novel therapeutic targets for prostate cancer.
DOI: 10.6084/m9.figshare.7618529.v2
title: MiR-30a-5p frequently downregulated in prostate cancer inhibits cell proliferation via targeting PCLAF

description: MicroRNAs (miRNAs) have vastly expanded our view of RNA world in intracellular signal regulating networks. Here, we functionally characterized a normally highly expressed miRNA, miR-30a-5p (MIMAT0000087), which exhibits downregulated expression profiles in prostate cancer samples. MiR-30a-5p knockdown and overexpression in PC-3 cell line alters cell proliferation supporting a tumour suppressor role. We also discovered that PCLAF is the direct target of miR-30a-5p. Notably, PC-3 cell proliferation is inhibited by miR-30a-5p/PCLAF axis. miR-30a-5p represents a novel molecule of functionally important miRNAs which may shed light on the novel therapeutic targets for prostate cancer.
DOI: 10.13018/bmr28133
title: Backbone 1H, 13C, 15N, and CB chemical shift assignments for the PDE6 inhibitory gamma-subunit (1-58)
DOI: 10.6084/m9.figshare.7618529.v1
title: MiR-30a-5p frequently downregulated in prostate cancer inhibits cell proliferation via targeting PCLAF

description: MicroRNAs (miRNAs) have vastly expanded our view of RNA world in intracellular signal regulating networks. Here, we functionally characterized a normally highly expressed miRNA, miR-30a-5p (MIMAT0000087), which exhibits downregulated expression profiles in prostate cancer samples. MiR-30a-5p knockdown and overexpression in PC-3 cell line alters cell proliferation supporting a tumour suppressor role. We also discovered that PCLAF is the direct target of miR-30a-5p. Notably, PC-3 cell proliferation is inhibited by miR-30a-5p/PCLAF axis. miR-30a-5p represents a novel molecule of functionally important miRNAs which may shed light on the novel therapeutic targets for prostate cancer.
DOI: 10.13018/bmr28134
title: Backbone 1H, 13C, 15N chemical shift assignment for the intrinsically disordered domain of chicken ANP32A
DOI: 10.15468/dl.j9t7de
title: Occurrence Download

description: A dataset containing 210 species occurrences available in GBIF matching the query:
{
 "and" : [
 "HasGeospatialIssue is false",
 "HasCoordinate is true",
 "OccurrenceStatus is Present",
 {
 "not" : {
 "BasisOfRecord" : [
 "is one of (Fossil, Living Specimen)"
 ]
 }
 },
 "DistanceFromCentroidInMeters is greater than or equal to 2000",
 "Geometry POLYGON ((105.610544 14.999999, 179.999961 14.999999, 179.999961 65.08290100000001, 105.610544 65.08290100000001, 105.610544 14.999999))",
 "TaxonKey is Plectroglyphidodon phoenixensis"
 ]
}

 The dataset includes 210 records from 5 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0003494-260225131425191/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.13018/bmr28135
title: Backbone 1H, 13C, and 15N Chemical Shift Assignments for the Intrinsically Disordered Domain of human ANP32A
DOI: 10.13018/bmr28136
title: Resonance Assignments for the Rabies Phosphoprotein RavP
DOI: 10.13018/bmr28137
title: Triple Resonance Assignments for the Rabies Phosphoprotein RavP (1-152)
DOI: 10.13018/bmr28138
title: Resonance Assignments for the Rabies Phosphoprotein RavP C terminus (140-297)
DOI: 10.13018/bmr28139
title: Backbone resonance assignment of dopamine N-acetyltransferase (Dat) in complex with Ac-CoA
DOI: 10.13018/bmr30000
title: Solution NMR structure of De novo designed PLOOP2X3_50 fold protein, Northeast Structural Genomics Consortium (NESG) target OR258
DOI: 10.13018/bmr30002
title: Solution Structure of p53TAD-TAZ1
DOI: 10.13018/bmr30003
title: Solution Structure of TAZ2-p53AD2
DOI: 10.13018/bmr30004
title: Solution Structure of TAZ2-p53TAD
DOI: 10.13018/bmr30005
title: Solution structure of coiled coil domain of myosin binding subunit of myosin light chain phosphatase
DOI: 10.13018/bmr30006
title: Solution structure of an octanoyl- loaded acyl carrier protein domain from module MLSA2 of the mycolactone polyketide synthase
DOI: 10.13018/bmr30007
title: Solution structure of the apo state of the acyl carrier protein from the MLSA2 subunit of the mycolactone polyketide synthase
DOI: 10.13018/bmr30008
title: Quantitative characterization of configurational space sampled by HIV-1 nucleocapsid using solution NMR and X-ray scattering
DOI: 10.13018/bmr30009
title: Resonance assignments and NMR structure determination of tarantula toxin, F8A mutant of beta-TRTX-Pre1a
DOI: 10.13018/bmr30010
title: Amphiphysin SH3 in complex with Chikungunya virus nsP3 peptide
DOI: 10.13018/bmr30011
title: Resonance assignments and NMR structure determination of tarantula toxin- W7A mutant of mu-TRTX-Pre1a
DOI: 10.13018/bmr30012
title: NMR structure of a new G-quadruplex forming sequence within the KRAS proto-oncogene promoter region
DOI: 10.13018/bmr30013
title: Solution structure of porcinelactoferricin in TFE
DOI: 10.5281/zenodo.18479901
title: Thermographic data for manuscript Mus.3356-D-45 (SLUB)

description: This data set contains thermographic images for the visualisation of watermarks. An IRCAM Equus 327k with Watermark Imager software (Fraunhofer) version 8.416 (R2016b) was used.
DOI: 10.13018/bmr30015
title: DNA duplex containing a ribonolactone lesion
DOI: 10.5281/zenodo.18479900
title: Thermographic data for manuscript Mus.3356-D-45 (SLUB)

description: This data set contains thermographic images for the visualisation of watermarks. An IRCAM Equus 327k with Watermark Imager software (Fraunhofer) version 8.416 (R2016b) was used.
DOI: 10.13018/bmr30016
title: DNA duplex containing a ribonolactone lesion
DOI: 10.13018/bmr30017
title: Solution Structure of human calcium-binding S100A9 (C3S) protein
DOI: 10.13018/bmr30019
title: NMR structure of UHRF1 Tandem Tudor Domains in a complex with Spacer peptide
DOI: 10.13018/bmr30020
title: The C-terminal domain of rice beta-galactosidase 1
DOI: 10.15468/dl.mg25e3
title: Occurrence Download

description: A dataset listing the 218 species recorded in GBIF matching the query:
{
 "DatasetKey" : [
 "is Inland water macroinvertebrate occurrences in Flanders, Belgium"
 ]
}

 The dataset's 218 records were derived from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0003480-260225131425191/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.