cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.3509906.v1
title: Anti-aging treatments slow propagation of synucleinopathy by restoring lysosomal function

description: Aging is the major risk factor for neurodegenerative diseases that are also associated with impaired proteostasis, resulting in abnormal accumulation of protein aggregates. However, the role of aging in development and progression of disease remains elusive. Here, we used <i>Caenorhabditis elegans</i> models to show that aging-promoting genetic variations accelerated the rate of cell-to-cell transmission of SNCA/α-synuclein aggregates, hallmarks of Parkinson disease, and the progression of disease phenotypes, such as nerve degeneration, behavioral deficits, and reduced life span. Genetic and pharmacological anti-aging manipulations slowed the spread of aggregates and the associated phenotypes. Lysosomal degradation was significantly impaired in aging models, while anti-aging treatments reduced the impairment. Transgenic expression of <i>hlh-30p::hlh-30</i>, the master controller of lysosomal biogenesis, alleviated intercellular transmission of aggregates in the aging model. Our results demonstrate that the rate of aging closely correlates with the rate of aggregate propagation and that general anti-aging treatments can slow aggregate propagation and associated disease progression by restoring lysosomal function.
DOI: 10.6084/m9.figshare.3509900
title: S1 Table.docx

description: <b>S1 Table. Primer sequences used for real-time fluorescence qPCR.</b> <br><br>
DOI: 10.6084/m9.figshare.3509900.v1
title: S1 Table.docx

description: <b>S1 Table. Primer sequences used for real-time fluorescence qPCR.</b> <br><br>
DOI: 10.6084/m9.figshare.3509852
title: fig1.tif

description: <b>Fig 1. Expression of IL-10 among the different groups.</b> A, mRNA expression of IL-10 in the UT tissue or NP tissue among groups. B, representative images of western blot assay and relative expression of IL-10 in the UT or NP among the groups. C, representative images of IL-10 immunohistochemistry and the number of IL-10 positive cells in the tissues from the different groups. CRSsNP, chronic rhinosinusitis without NP; CRSwNP, chronic rhinosinusitis with NP. *=<i>p</i>&lt;0.05, **=<i>p</i>&lt;0.01, ***=<i>p</i>&lt;0.001. <br><br>
DOI: 10.6084/m9.figshare.3509852.v1
title: fig1.tif

description: <b>Fig 1. Expression of IL-10 among the different groups.</b> A, mRNA expression of IL-10 in the UT tissue or NP tissue among groups. B, representative images of western blot assay and relative expression of IL-10 in the UT or NP among the groups. C, representative images of IL-10 immunohistochemistry and the number of IL-10 positive cells in the tissues from the different groups. CRSsNP, chronic rhinosinusitis without NP; CRSwNP, chronic rhinosinusitis with NP. *=<i>p</i>&lt;0.05, **=<i>p</i>&lt;0.01, ***=<i>p</i>&lt;0.001. <br><br>
DOI: 10.4225/03/57e0a09b60eed
title: The Australia Indonesia Centre (AIC)

description: The Australia-Indonesia Centre was established by the Australian Government in late 2013 to facilitate research-driven innovation and build stronger relationships between Australia and Indonesia. The Centre, hosted by Monash University, is a collaboration between Monash University, the Australian National University, the University of Melbourne and the University of Sydney, working with seven leading Indonesian universities.<br><b>Vision</b>The Australia-Indonesia Centre becomes the pre-eminent facilitator of multi-stakeholder collaboration between Australia and Indonesia to generate high-impact research and activities.<br><b>Objectives</b>The Australia-Indonesia Centre (AIC) has three Core Objectives set in consultation with the Australian Government. They are to:• Strengthen and deepen Australia-Indonesia linkages and relationships across many sectors of society.• Pursue solutions to shared national challenges in areas such as Health, Food, Energy and Infrastructure via highly collaborative research.• Promote greater understanding and cultural awareness – Australians of Indonesia, and Indonesians of Australia.<br><b>Publications</b>The Australia-Indonesia Centre produces a range of reports and publications. Full brochures for our Leaders Programs as well as Scientific, Industry and Sociological Research Reports are available<br>
DOI: 10.6084/m9.figshare.3509816
title: Psychiatric medication preferences of sports psychiatrists

description: <b>Objectives:</b> When prescribing psychiatric medications to athletes, it is important to consider issues that are especially important for this population, including side effects, safety concerns, and anti-doping policies. Only one report, from 2000, describes the prescribing preferences of psychiatrists who work with athletes. This manuscript aims to update the findings from that report, so as to help inform prescribing practices of primary care physicians, psychiatrists, and other clinicians who work with athletes. <b>Methods:</b> Physician members of the International Society for Sports Psychiatry (ISSP) were sent an email invitation in 2016 to complete an anonymous web-based survey on psychiatric medication prescribing preferences in working with athletes with a variety of mental health conditions. <b>Results:</b> Forty of 100 (40%) members of the ISSP who identified as physicians and who were emailed the survey ultimately completed it. Top choices of psychiatric medications for athletes across categories assessed included: bupropion for depression without anxiety and without bipolar spectrum disorder; escitalopram for generalized anxiety disorder; melatonin for insomnia; atomoxetine for attention-deficit/hyperactivity disorder; lamotrigine for bipolar spectrum disorders; and aripiprazole for psychotic disorders. <b>Conclusion:</b> Prescribers of psychiatric medications for athletes tended to favor medications that are relatively more energizing and less likely to cause sedation, weight gain, cardiac side effects, and tremor. Additionally, prescribing preferences for athletes diverged from many of the prescribing trends seen for patients within the general population, in keeping with the assumption that different factors are considered when prescribing for athletes versus for the general population.
DOI: 10.6084/m9.figshare.3509816.v1
title: Psychiatric medication preferences of sports psychiatrists

description: <b>Objectives:</b> When prescribing psychiatric medications to athletes, it is important to consider issues that are especially important for this population, including side effects, safety concerns, and anti-doping policies. Only one report, from 2000, describes the prescribing preferences of psychiatrists who work with athletes. This manuscript aims to update the findings from that report, so as to help inform prescribing practices of primary care physicians, psychiatrists, and other clinicians who work with athletes. <b>Methods:</b> Physician members of the International Society for Sports Psychiatry (ISSP) were sent an email invitation in 2016 to complete an anonymous web-based survey on psychiatric medication prescribing preferences in working with athletes with a variety of mental health conditions. <b>Results:</b> Forty of 100 (40%) members of the ISSP who identified as physicians and who were emailed the survey ultimately completed it. Top choices of psychiatric medications for athletes across categories assessed included: bupropion for depression without anxiety and without bipolar spectrum disorder; escitalopram for generalized anxiety disorder; melatonin for insomnia; atomoxetine for attention-deficit/hyperactivity disorder; lamotrigine for bipolar spectrum disorders; and aripiprazole for psychotic disorders. <b>Conclusion:</b> Prescribers of psychiatric medications for athletes tended to favor medications that are relatively more energizing and less likely to cause sedation, weight gain, cardiac side effects, and tremor. Additionally, prescribing preferences for athletes diverged from many of the prescribing trends seen for patients within the general population, in keeping with the assumption that different factors are considered when prescribing for athletes versus for the general population.
DOI: 10.6084/m9.figshare.3509669
title: Data on effects of fire on cattle-wildlife interactions

description: These are data for our publication in the Journal of Applied Ecology entitled "Fire-induced negative nutritional outcomes for cattle sharing habitat with native ungulates in an African savanna". The file contains data on vegetation attributes, cattle nutrition attributes and wildlife camera trap photos. All measurements were made on burned and unburned areas cattle accessed exclusively or shared with wild herbivores. All data were collected in the Kenya Long-term Exclosure Experiment (KLEE) experimental plots during April 2013-February 2014.
DOI: 10.6084/m9.figshare.3509669.v1
title: Data on effects of fire on cattle-wildlife interactions

description: These are data for our publication in the Journal of Applied Ecology entitled "Fire-induced negative nutritional outcomes for cattle sharing habitat with native ungulates in an African savanna". The file contains data on vegetation attributes, cattle nutrition attributes and wildlife camera trap photos. All measurements were made on burned and unburned areas cattle accessed exclusively or shared with wild herbivores. All data were collected in the Kenya Long-term Exclosure Experiment (KLEE) experimental plots during April 2013-February 2014.
DOI: 10.6084/m9.figshare.3509660
title: DNA sequence of the gp63 fragment encoding the functional domain of leishmanolysin in natural isolates of Leishmania braziliensis from Corte de Pedra, Northeast Brazil: allele 45.

description: DNA sequence of the gp63 fragment encoding the functional domain of leishmanolysin in natural isolates of Leishmania braziliensis from Corte de Pedra, Northeast Brazil: allele 45. The stretch of gp 63 previously described as encoding the functional domain of the molecule was amplified by PCR, cloned into pcr 2.1 vector and bidirectionally sequenced. Sequences from a panel of 41 parasite isolates were aligned and 45 alleles of the fragment could be identified based on indel and SNPs presented among cloned domains. Haplotypes of polymorphisms (indel and SNPs) that could be detected in at least two clones of the gp63 domain in a single isolate, and in at least two parasite isolates in the collection were considered alleles. Corte de Pedra is a region highly endemic for American tegumentary leishmaniasis (ATL) due to L. braziliensis. Several forms of ATL occur and close to 1,500 new cases are diagnosed in the region each year.
DOI: 10.6084/m9.figshare.3509660.v2
title: DNA sequence of the gp63 fragment encoding the functional domain of leishmanolysin in natural isolates of Leishmania braziliensis from Corte de Pedra, Northeast Brazil: allele 45.

description: DNA sequence of the gp63 fragment encoding the functional domain of leishmanolysin in natural isolates of Leishmania braziliensis from Corte de Pedra, Northeast Brazil: allele 45. The stretch of gp 63 previously described as encoding the functional domain of the molecule was amplified by PCR, cloned into pcr 2.1 vector and bidirectionally sequenced. Sequences from a panel of 41 parasite isolates were aligned and 45 alleles of the fragment could be identified based on indel and SNPs presented among cloned domains. Haplotypes of polymorphisms (indel and SNPs) that could be detected in at least two clones of the gp63 domain in a single isolate, and in at least two parasite isolates in the collection were considered alleles. Corte de Pedra is a region highly endemic for American tegumentary leishmaniasis (ATL) due to L. braziliensis. Several forms of ATL occur and close to 1,500 new cases are diagnosed in the region each year.
DOI: 10.6084/m9.figshare.3509660.v1
title: Leishmania_braziliensis_gp63_functional_domain_sequence 45.fas

description: Leishmania braziliensis gp63 functional domain sequence 45
DOI: 10.6084/m9.figshare.3509657
title: DNA sequence of the gp63 fragment encoding the functional domain of leishmanolysin in natural isolates of Leishmania braziliensis from Corte de Pedra, Northeast Brazil: allele 44.

description: DNA sequence of the gp63 fragment encoding the functional domain of leishmanolysin in natural isolates of Leishmania braziliensis from Corte de Pedra, Northeast Brazil: allele 44. The stretch of gp 63 previously described as encoding the functional domain of the molecule was amplified by PCR, cloned into pcr 2.1 vector and bidirectionally sequenced. Sequences from a panel of 41 parasite isolates were aligned and 45 alleles of the fragment could be identified based on indel and SNPs presented among cloned domains. Haplotypes of polymorphisms (indel and SNPs) that could be detected in at least two clones of the gp63 domain in a single isolate, and in at least two parasite isolates in the collection were considered alleles. Corte de Pedra is a region highly endemic for American tegumentary leishmaniasis (ATL) due to L. braziliensis. Several forms of ATL occur and close to 1,500 new cases are diagnosed in the region each year.
DOI: 10.6084/m9.figshare.3509657.v2
title: DNA sequence of the gp63 fragment encoding the functional domain of leishmanolysin in natural isolates of Leishmania braziliensis from Corte de Pedra, Northeast Brazil: allele 44.

description: DNA sequence of the gp63 fragment encoding the functional domain of leishmanolysin in natural isolates of Leishmania braziliensis from Corte de Pedra, Northeast Brazil: allele 44. The stretch of gp 63 previously described as encoding the functional domain of the molecule was amplified by PCR, cloned into pcr 2.1 vector and bidirectionally sequenced. Sequences from a panel of 41 parasite isolates were aligned and 45 alleles of the fragment could be identified based on indel and SNPs presented among cloned domains. Haplotypes of polymorphisms (indel and SNPs) that could be detected in at least two clones of the gp63 domain in a single isolate, and in at least two parasite isolates in the collection were considered alleles. Corte de Pedra is a region highly endemic for American tegumentary leishmaniasis (ATL) due to L. braziliensis. Several forms of ATL occur and close to 1,500 new cases are diagnosed in the region each year.
DOI: 10.6084/m9.figshare.3509657.v1
title: Leishmania_braziliensis_gp63_functional_domain_sequence 44.fas

description: Leishmania braziliensis gp63 functional domain sequence 44
DOI: 10.6084/m9.figshare.3509654
title: DNA sequence of the gp63 fragment encoding the functional domain of leishmanolysin in natural isolates of Leishmania braziliensis from Corte de Pedra, Northeast Brazil: allele 43.

description: DNA sequence of the gp63 fragment encoding the functional domain of leishmanolysin in natural isolates of Leishmania braziliensis from Corte de Pedra, Northeast Brazil: allele 43. The stretch of gp 63 previously described as encoding the functional domain of the molecule was amplified by PCR, cloned into pcr 2.1 vector and bidirectionally sequenced. Sequences from a panel of 41 parasite isolates were aligned and 45 alleles of the fragment could be identified based on indel and SNPs presented among cloned domains. Haplotypes of polymorphisms (indel and SNPs) that could be detected in at least two clones of the gp63 domain in a single isolate, and in at least two parasite isolates in the collection were considered alleles. Corte de Pedra is a region highly endemic for American tegumentary leishmaniasis (ATL) due to L. braziliensis. Several forms of ATL occur and close to 1,500 new cases are diagnosed in the region each year.
DOI: 10.6084/m9.figshare.3509654.v2
title: DNA sequence of the gp63 fragment encoding the functional domain of leishmanolysin in natural isolates of Leishmania braziliensis from Corte de Pedra, Northeast Brazil: allele 43.

description: DNA sequence of the gp63 fragment encoding the functional domain of leishmanolysin in natural isolates of Leishmania braziliensis from Corte de Pedra, Northeast Brazil: allele 43. The stretch of gp 63 previously described as encoding the functional domain of the molecule was amplified by PCR, cloned into pcr 2.1 vector and bidirectionally sequenced. Sequences from a panel of 41 parasite isolates were aligned and 45 alleles of the fragment could be identified based on indel and SNPs presented among cloned domains. Haplotypes of polymorphisms (indel and SNPs) that could be detected in at least two clones of the gp63 domain in a single isolate, and in at least two parasite isolates in the collection were considered alleles. Corte de Pedra is a region highly endemic for American tegumentary leishmaniasis (ATL) due to L. braziliensis. Several forms of ATL occur and close to 1,500 new cases are diagnosed in the region each year.
DOI: 10.6084/m9.figshare.3509654.v1
title: Leishmania_braziliensis_gp63_functional_domain_sequence 43.fas

description: Leishmania braziliensis gp63 functional domain sequence 43
DOI: 10.6084/m9.figshare.3509651
title: DNA sequence of the gp63 fragment encoding the functional domain of leishmanolysin in natural isolates of Leishmania braziliensis from Corte de Pedra, Northeast Brazil: allele 42.

description: DNA sequence of the gp63 fragment encoding the functional domain of leishmanolysin in natural isolates of Leishmania braziliensis from Corte de Pedra, Northeast Brazil: allele 42. The stretch of gp 63 previously described as encoding the functional domain of the molecule was amplified by PCR, cloned into pcr 2.1 vector and bidirectionally sequenced. Sequences from a panel of 41 parasite isolates were aligned and 45 alleles of the fragment could be identified based on indel and SNPs presented among cloned domains. Haplotypes of polymorphisms (indel and SNPs) that could be detected in at least two clones of the gp63 domain in a single isolate, and in at least two parasite isolates in the collection were considered alleles. Corte de Pedra is a region highly endemic for American tegumentary leishmaniasis (ATL) due to L. braziliensis. Several forms of ATL occur and close to 1,500 new cases are diagnosed in the region each year.
DOI: 10.6084/m9.figshare.3509651.v2
title: DNA sequence of the gp63 fragment encoding the functional domain of leishmanolysin in natural isolates of Leishmania braziliensis from Corte de Pedra, Northeast Brazil: allele 42.

description: DNA sequence of the gp63 fragment encoding the functional domain of leishmanolysin in natural isolates of Leishmania braziliensis from Corte de Pedra, Northeast Brazil: allele 42. The stretch of gp 63 previously described as encoding the functional domain of the molecule was amplified by PCR, cloned into pcr 2.1 vector and bidirectionally sequenced. Sequences from a panel of 41 parasite isolates were aligned and 45 alleles of the fragment could be identified based on indel and SNPs presented among cloned domains. Haplotypes of polymorphisms (indel and SNPs) that could be detected in at least two clones of the gp63 domain in a single isolate, and in at least two parasite isolates in the collection were considered alleles. Corte de Pedra is a region highly endemic for American tegumentary leishmaniasis (ATL) due to L. braziliensis. Several forms of ATL occur and close to 1,500 new cases are diagnosed in the region each year.
DOI: 10.6084/m9.figshare.3509651.v1
title: Leishmania_braziliensis_gp63_functional_domain_sequence 42.fas

description: Leishmania braziliensis gp63 functional domain sequence 42
DOI: 10.6084/m9.figshare.3509648
title: DNA sequence of the gp63 fragment encoding the functional domain of leishmanolysin in natural isolates of Leishmania braziliensis from Corte de Pedra, Northeast Brazil: allele 41.

description: DNA sequence of the gp63 fragment encoding the functional domain of leishmanolysin in natural isolates of Leishmania braziliensis from Corte de Pedra, Northeast Brazil: allele 41. The stretch of gp 63 previously described as encoding the functional domain of the molecule was amplified by PCR, cloned into pcr 2.1 vector and bidirectionally sequenced. Sequences from a panel of 41 parasite isolates were aligned and 45 alleles of the fragment could be identified based on indel and SNPs presented among cloned domains. Haplotypes of polymorphisms (indel and SNPs) that could be detected in at least two clones of the gp63 domain in a single isolate, and in at least two parasite isolates in the collection were considered alleles. Corte de Pedra is a region highly endemic for American tegumentary leishmaniasis (ATL) due to L. braziliensis. Several forms of ATL occur and close to 1,500 new cases are diagnosed in the region each year.
DOI: 10.6084/m9.figshare.3509648.v2
title: DNA sequence of the gp63 fragment encoding the functional domain of leishmanolysin in natural isolates of Leishmania braziliensis from Corte de Pedra, Northeast Brazil: allele 41.

description: DNA sequence of the gp63 fragment encoding the functional domain of leishmanolysin in natural isolates of Leishmania braziliensis from Corte de Pedra, Northeast Brazil: allele 41. The stretch of gp 63 previously described as encoding the functional domain of the molecule was amplified by PCR, cloned into pcr 2.1 vector and bidirectionally sequenced. Sequences from a panel of 41 parasite isolates were aligned and 45 alleles of the fragment could be identified based on indel and SNPs presented among cloned domains. Haplotypes of polymorphisms (indel and SNPs) that could be detected in at least two clones of the gp63 domain in a single isolate, and in at least two parasite isolates in the collection were considered alleles. Corte de Pedra is a region highly endemic for American tegumentary leishmaniasis (ATL) due to L. braziliensis. Several forms of ATL occur and close to 1,500 new cases are diagnosed in the region each year.
DOI: 10.6084/m9.figshare.3509648.v1
title: Leishmania_braziliensis_gp63_functional_domain_sequence 41.fas

description: Leishmania braziliensis gp63 functional domain sequence 41
DOI: 10.6084/m9.figshare.3509645
title: DNA sequence of the gp63 fragment encoding the functional domain of leishmanolysin in natural isolates of Leishmania braziliensis from Corte de Pedra, Northeast Brazil: allele 40.

description: DNA sequence of the gp63 fragment encoding the functional domain of leishmanolysin in natural isolates of Leishmania braziliensis from Corte de Pedra, Northeast Brazil: allele 40. The stretch of gp 63 previously described as encoding the functional domain of the molecule was amplified by PCR, cloned into pcr 2.1 vector and bidirectionally sequenced. Sequences from a panel of 41 parasite isolates were aligned and 45 alleles of the fragment could be identified based on indel and SNPs presented among cloned domains. Haplotypes of polymorphisms (indel and SNPs) that could be detected in at least two clones of the gp63 domain in a single isolate, and in at least two parasite isolates in the collection were considered alleles. Corte de Pedra is a region highly endemic for American tegumentary leishmaniasis (ATL) due to L. braziliensis. Several forms of ATL occur and close to 1,500 new cases are diagnosed in the region each year.
DOI: 10.6084/m9.figshare.3509645.v1
title: Leishmania_braziliensis_gp63_functional_domain_sequence 40.fas

description: DNA sequence of the gp63 fragment encoding the functional domain of leishmanolysin in natural isolates of Leishmania braziliensis from Corte de Pedra, Northeast Brazil: allele 40. The stretch of gp 63 previously described as encoding the functional domain of the molecule was amplified by PCR, cloned into pcr 2.1 vector and bidirectionally sequenced. Sequences from a panel of 41 parasite isolates were aligned and 45 alleles of the fragment could be identified based on indel and SNPs presented among cloned domains. Haplotypes of polymorphisms (indel and SNPs) that could be detected in at least two clones of the gp63 domain in a single isolate, and in at least two parasite isolates in the collection were considered alleles. Corte de Pedra is a region highly endemic for American tegumentary leishmaniasis (ATL) due to L. braziliensis. Several forms of ATL occur and close to 1,500 new cases are diagnosed in the region each year.