cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.11636301.v1
title: MOESM1 of A method for functional testing constitutive and ligand-induced interactions of lysin motif receptor proteins

description: Additional file 1: Table S1. List of primers used in this study. Table S2. List of plasmids used in this study. Table S3. Transformation efficiency of L. japonicus MG-20 as estimated by the ratio of GUS-positive hairy roots to the total number of formed hairy roots. Table S4. Transformation efficiency of the L. japonicus mutants nfr1-1 and nfr5-2 as estimated by the ratio of GUS-positive hairy roots to the total number of formed hairy roots.
DOI: 10.6084/m9.figshare.11636253
title: MOESM8 of Enteric infection induces Lark-mediated intron retention at the 5′ end of Drosophila genes

description: Additional file 8. lark differential expression and GSEA analyses. Sheet1. Combined differential expression top tables for the three analyses (rnai = RNAi vs WT, uas = UAS.lark vs WT, infection = all infected vs all uninfected). Sheet2. Results of the GSEA analysis based on the logFC values of each gene and gene ontology terms acquired from go2msig.org (April 2015).
DOI: 10.6084/m9.figshare.11636253.v1
title: MOESM8 of Enteric infection induces Lark-mediated intron retention at the 5′ end of Drosophila genes

description: Additional file 8. lark differential expression and GSEA analyses. Sheet1. Combined differential expression top tables for the three analyses (rnai = RNAi vs WT, uas = UAS.lark vs WT, infection = all infected vs all uninfected). Sheet2. Results of the GSEA analysis based on the logFC values of each gene and gene ontology terms acquired from go2msig.org (April 2015).
DOI: 10.6084/m9.figshare.11636241
title: MOESM7 of Enteric infection induces Lark-mediated intron retention at the 5′ end of Drosophila genes

description: Additional file 7. Intron retention results. Sheet1. Intron retention annotations and results for the DGRP lines. Sheet2. DGRP PSI table per sample. Sheet3. DGRP delta PSI table per strain. Sheet4. DGRP bayes factor table for infection effect comparisons. Sheet5. Significantly changed intron retentions in the w1118 background (Ecc15 or Pe infection). Sheet6. Intron retention events in the different lark perturbation experiments. TRUE means that the event is significantly different in the performed comparison. Sheet7. Summary of overlap with uORF by DGRP line: overlaps were calculated for all, or the significant subset of introns per DGRP strain.
DOI: 10.6084/m9.figshare.11636244
title: MOESM4 of Psychotropic medication non-adherence and its associated factors among patients with major psychiatric disorders: a systematic review and meta-analysis

description: Additional file 4. Data extraction on Excel sheet
DOI: 10.6084/m9.figshare.11636244.v1
title: MOESM4 of Psychotropic medication non-adherence and its associated factors among patients with major psychiatric disorders: a systematic review and meta-analysis

description: Additional file 4. Data extraction on Excel sheet
DOI: 10.6084/m9.figshare.11636241.v1
title: MOESM7 of Enteric infection induces Lark-mediated intron retention at the 5′ end of Drosophila genes

description: Additional file 7. Intron retention results. Sheet1. Intron retention annotations and results for the DGRP lines. Sheet2. DGRP PSI table per sample. Sheet3. DGRP delta PSI table per strain. Sheet4. DGRP bayes factor table for infection effect comparisons. Sheet5. Significantly changed intron retentions in the w1118 background (Ecc15 or Pe infection). Sheet6. Intron retention events in the different lark perturbation experiments. TRUE means that the event is significantly different in the performed comparison. Sheet7. Summary of overlap with uORF by DGRP line: overlaps were calculated for all, or the significant subset of introns per DGRP strain.
DOI: 10.6084/m9.figshare.11636232
title: MOESM6 of Enteric infection induces Lark-mediated intron retention at the 5′ end of Drosophila genes

description: Additional file 6. Lengths of transcripts and effective lengths of genes. Sheet1. Lengths of transcripts and features from reference annotation. Sheet2. transcript lengths by DGRP line (taking indels into account). Sheet3. CDS lengths by DGRP line (taking indels into account). Sheet 4. 5’UTR lengths by DGRP line (taking indels into account). Sheet5. 3’UTR lengths by DGRP line (taking indels into account). Sheet6. Gene effective length by transcript (taking indels and isoform ratios into account). Sheet7. Gene effective length by 5’UTR lengths (taking indels and isoform ratios into account). Sheet8. Gene effective length by 3’UTR lengths (taking indels and isoform ratios into account).
DOI: 10.6084/m9.figshare.11636223
title: MOESM5 of Enteric infection induces Lark-mediated intron retention at the 5′ end of Drosophila genes

description: Additional file 5. sQTL results. Sheet1. All sQTL results in both conditions (Control and Treated). Sheet2. Significant sQTL results in both conditions, along with predicted coding consequence, location within transcript, and matches to the ESE and ISE. Reference list for ESE and ISI.
DOI: 10.6084/m9.figshare.11636223.v1
title: MOESM5 of Enteric infection induces Lark-mediated intron retention at the 5′ end of Drosophila genes

description: Additional file 5. sQTL results. Sheet1. All sQTL results in both conditions (Control and Treated). Sheet2. Significant sQTL results in both conditions, along with predicted coding consequence, location within transcript, and matches to the ESE and ISE. Reference list for ESE and ISI.
DOI: 10.6084/m9.figshare.11636214
title: MOESM4 of Enteric infection induces Lark-mediated intron retention at the 5′ end of Drosophila genes

description: Additional file 4. Shannon diversity results. Sheet1: Shannon diversity per gene per DGRP sample. Sheet2: Delta Shannon diversity (Infected – Control) per gene per DGRP line.
DOI: 10.6084/m9.figshare.11636214.v1
title: MOESM4 of Enteric infection induces Lark-mediated intron retention at the 5′ end of Drosophila genes

description: Additional file 4. Shannon diversity results. Sheet1: Shannon diversity per gene per DGRP sample. Sheet2: Delta Shannon diversity (Infected – Control) per gene per DGRP line.
DOI: 10.6084/m9.figshare.11636205
title: MOESM3 of Enteric infection induces Lark-mediated intron retention at the 5′ end of Drosophila genes

description: Additional file 3. Infection-induced transcript isoform changes. Sheet1. All PSI values per transcript as calculated using MISO. RASP results for infection effect. GO results for infection effect. Differential expression results for infection effect (companion study).
DOI: 10.6084/m9.figshare.11636205.v1
title: MOESM3 of Enteric infection induces Lark-mediated intron retention at the 5′ end of Drosophila genes

description: Additional file 3. Infection-induced transcript isoform changes. Sheet1. All PSI values per transcript as calculated using MISO. RASP results for infection effect. GO results for infection effect. Differential expression results for infection effect (companion study).
DOI: 10.6084/m9.figshare.11636199
title: MOESM2 of Enteric infection induces Lark-mediated intron retention at the 5′ end of Drosophila genes

description: Additional file 2. RNA-samples used in the study and metadata. Sheet1. DGRP RNA samples used in the study. Sheet2. w1118 RNA samples used in the study. Sheet3. lark perturbation samples used in the study.
DOI: 10.6084/m9.figshare.11636199.v1
title: MOESM2 of Enteric infection induces Lark-mediated intron retention at the 5′ end of Drosophila genes

description: Additional file 2. RNA-samples used in the study and metadata. Sheet1. DGRP RNA samples used in the study. Sheet2. w1118 RNA samples used in the study. Sheet3. lark perturbation samples used in the study.
DOI: 10.6084/m9.figshare.11635995
title: Supplementary Material for: The Bidirectional Association between Inflammatory Bowel Disease and Atopic Dermatitis: A Systematic Review and Meta-Analysis

description: <b><i>Background:</i></b> Previous investigations have suggested a significant association between inflammatory bowel disease (IBD) and atopic dermatitis (AD). Yet, outcomes published remain inconsistent. <b><i>Objective:</i></b> To explore the association between IBD and AD by a systematic review and meta-analysis. <b><i>Methods:</i></b> A comprehensive search of studies published from March 1, 1968, to July 26, 2019, was performed in electronic databases as follows: PubMed, Embase, Cochrane Library, and Web of Science. Methodological quality was assessed based on the Newcastle-Ottawa Scale. Data analysis was conducted using R version 3.6.1 (meta package version 4.9-7). <b><i>Results:</i></b> A total of 14 studies were eligible for exploring the association between IBD and AD. Statistically significant differences were found on the risk of AD comorbidity among patients with IBD (risk ratio [RR] 1.83, 95% CI 1.39–2.40), Crohn’s disease (CD; RR 2.06, 95% CI 1.61–2.64), and ulcerative colitis (UC; RR 1.66, 95% CI 1.23–2.24). Compared with non-AD subjects, patients with AD were 48% (<i>p</i> = 0.019), 44% (<i>p</i> = 0.002), and 38% (<i>p</i> = 0.000) more likely to exhibit IBD, CD as well as UC, respectively. <b><i>Discussion:</i></b> Our evidence supported a significant bidirectional association between IBD and AD. Future prospective studies are warranted to explore underlying mechanisms linking them.
DOI: 10.6084/m9.figshare.11635971
title: Supplementary_Figure_1.newick

description: Newick file used to generate Supplementary Figure 1.
DOI: 10.6084/m9.figshare.11635971.v1
title: Supplementary_Figure_1.newick

description: Newick file used to generate Supplementary Figure 1.
DOI: 10.6084/m9.figshare.11635965
title: Kleb_phage_review_192_genomes.fasta

description: Fasta file of genome sequences used to generate Figure 1.
DOI: 10.6084/m9.figshare.11635965.v1
title: Kleb_phage_review_192_genomes.fasta

description: Fasta file of genome sequences used to generate Figure 1.
DOI: 10.6084/m9.figshare.11635953
title: Figure_1.newick

description: Newick file for Figure 1 in article.
DOI: 10.6084/m9.figshare.11635950
title: Supplementary_Figure_1_genome_table_file.lst

description: List of genomes used to create Figure 1.
DOI: 10.6084/m9.figshare.11635953.v1
title: Figure_1.newick

description: Newick file for Figure 1 in article.
DOI: 10.6084/m9.figshare.11635950.v1
title: Supplementary_Figure_1_genome_table_file.lst

description: List of genomes used to create Figure 1.
DOI: 10.25392/leicester.data.11635914
title: Desert Island Discs Corpus: Guest speaker classifications (1960s, 1980s, 2000s)

description: This file lists guest speakers who were sampled in a study by Nicholas Smith of language use in the BBC Radio show <i>Desert Island Discs</i>. Article title: 'Conversationalization and democratization in a radio chat show: A grammar-led investigation', to be published in <i>Language Sciences</i> in 2020. Corpus design by Nicholas Smith and Cathleen Waters. Speaker classifications by sex, age, occupation and education categories are given for four periods: two periods (1960s, early 1980s) with Roy Plomley as host, and two periods (late 1980s and early 2000s) with Sue Lawley as host. Also included is the start time of each recording sampled. Word counts obtained by Wmatrix (http://ucrel.lancs.ac.uk/wmatrix/).<br>
DOI: 10.25392/leicester.data.11635914.v1
title: Desert Island Discs Corpus: Guest speaker classifications (1960s, 1980s, 2000s)

description: This file lists guest speakers who were sampled in a study by Nicholas Smith of language use in the BBC Radio show <i>Desert Island Discs</i>. Article title: 'Conversationalization and democratization in a radio chat show: A grammar-led investigation', to be published in <i>Language Sciences</i> in 2020. Corpus design by Nicholas Smith and Cathleen Waters. Speaker classifications by sex, age, occupation and education categories are given for four periods: two periods (1960s, early 1980s) with Roy Plomley as host, and two periods (late 1980s and early 2000s) with Sue Lawley as host. Also included is the start time of each recording sampled. Word counts obtained by Wmatrix (http://ucrel.lancs.ac.uk/wmatrix/).<br>
DOI: 10.6084/m9.figshare.11635719
title: Base de datos de tuits de Maldita Ciencia

description: Base de datos de los tuits publicados por Maldita Ciencia en su primer año.<br>
DOI: 10.6084/m9.figshare.11635719.v1
title: Base de datos de tuits de Maldita Ciencia

description: Base de datos de los tuits publicados por Maldita Ciencia en su primer año.<br>
DOI: 10.6084/m9.figshare.11635386
title: Perval - WO.sav

description: research database on perceived value of vegetarian food.
DOI: 10.6084/m9.figshare.11635368
title: An Ag(I)-pyridyl-triazole coordination polymer: treatment effect on HBV-associated glomerulonephritis via inhibiting inflammatory genes expression

description: In this study, a new Ag(I)-based coordination polymer (CP) with the chemical formula of {[Ag(L)(NO<sub>3</sub>)](H<sub>2</sub>O)(MeOH)}<sub>n</sub> (Ag(I)-CP, L = 3,5-bis(4-pyridyl)-4-(3-pyridyl)-1,2,4-triazole) has been prepared via assembling the pyridyl-triazole linker L and AgNO<sub>2</sub> in a mixed solvent of CH<sub>2</sub>Cl<sub>2</sub> and MeOH. Furthermore, a green grinding treatment method was used to produce the nano sheets of Ag(I)-CP with good water dispersibility. In biological experiment, the relative expression level of the nuclear factor-κB (NF-κB), phosphoinositide 3 kinase (PI3K), Ras-Raf-mitogen-activated protein kinase (MAPK) in mRNA level and protein level in HBV infected human renal proximal tubule epithelial cells after nano Ag(I)-CP treatment was detected by RT-PCR and western blot. Molecular docking was finally employed to probe the possible binding interaction of the structure Ag(I)-CP to the DNA protein and non-covalent binding mode was found.
DOI: 10.6084/m9.figshare.11635368.v1
title: An Ag(I)-pyridyl-triazole coordination polymer: treatment effect on HBV-associated glomerulonephritis via inhibiting inflammatory genes expression

description: In this study, a new Ag(I)-based coordination polymer (CP) with the chemical formula of {[Ag(L)(NO<sub>3</sub>)](H<sub>2</sub>O)(MeOH)}<sub>n</sub> (Ag(I)-CP, L = 3,5-bis(4-pyridyl)-4-(3-pyridyl)-1,2,4-triazole) has been prepared via assembling the pyridyl-triazole linker L and AgNO<sub>2</sub> in a mixed solvent of CH<sub>2</sub>Cl<sub>2</sub> and MeOH. Furthermore, a green grinding treatment method was used to produce the nano sheets of Ag(I)-CP with good water dispersibility. In biological experiment, the relative expression level of the nuclear factor-κB (NF-κB), phosphoinositide 3 kinase (PI3K), Ras-Raf-mitogen-activated protein kinase (MAPK) in mRNA level and protein level in HBV infected human renal proximal tubule epithelial cells after nano Ag(I)-CP treatment was detected by RT-PCR and western blot. Molecular docking was finally employed to probe the possible binding interaction of the structure Ag(I)-CP to the DNA protein and non-covalent binding mode was found.
DOI: 10.6084/m9.figshare.11635332
title: Synthesis of a crystalline nanoscale Co(II)-coordination polymer based on the 4,4′-bis(imidazol-1-yl)-biphenyl ligand: structural characterization and liver cancer cell growth inhibition

description: A new Co(II)-bearing coordination polymer (CP) namely, [Co<sub>2</sub>(bimb)<sub>2</sub>(HCOO)<sub>3</sub>](NO<sub>3</sub>) (<b>1</b>) has been successfully prepared by reaction of Co(NO<sub>3</sub>)<sub>2</sub>·6H<sub>2</sub>O and 4,4′-bis(imidazol-1-yl)-biphenyl (bimb) in a mixed solvent of DMF and water though adopting a solvothermal technique. Furthermore, a green hand grinding technique has been implemented to reduce the particle size of the complex <b>1</b> to generate nanoscale <b>1</b> (denoted as nano <b>1</b> hereafter). Then, the cell Counting Kit-8 (CCK-8) assay was performed to evaluate the anti-viability activity of compound. The reactive oxygen species (ROS) in the cells after compound was measured with detection kit, and the ROS relative genes expression were detected by RT-PCR.
DOI: 10.6084/m9.figshare.11635332.v1
title: Synthesis of a crystalline nanoscale Co(II)-coordination polymer based on the 4,4′-bis(imidazol-1-yl)-biphenyl ligand: structural characterization and liver cancer cell growth inhibition

description: A new Co(II)-bearing coordination polymer (CP) namely, [Co<sub>2</sub>(bimb)<sub>2</sub>(HCOO)<sub>3</sub>](NO<sub>3</sub>) (<b>1</b>) has been successfully prepared by reaction of Co(NO<sub>3</sub>)<sub>2</sub>·6H<sub>2</sub>O and 4,4′-bis(imidazol-1-yl)-biphenyl (bimb) in a mixed solvent of DMF and water though adopting a solvothermal technique. Furthermore, a green hand grinding technique has been implemented to reduce the particle size of the complex <b>1</b> to generate nanoscale <b>1</b> (denoted as nano <b>1</b> hereafter). Then, the cell Counting Kit-8 (CCK-8) assay was performed to evaluate the anti-viability activity of compound. The reactive oxygen species (ROS) in the cells after compound was measured with detection kit, and the ROS relative genes expression were detected by RT-PCR.
DOI: 10.6084/m9.figshare.11635068
title: Additional file 1: of Genomic surveillance for hypervirulence and multi-drug resistance in invasive Klebsiella pneumoniae from South and Southeast Asia

description: Table S1. Sample information and genotyping results for all BSI Kp included in this study.
DOI: 10.6084/m9.figshare.11635068.v1
title: Additional file 1: of Genomic surveillance for hypervirulence and multi-drug resistance in invasive Klebsiella pneumoniae from South and Southeast Asia

description: Table S1. Sample information and genotyping results for all BSI Kp included in this study.
DOI: 10.6084/m9.figshare.11635056
title: MOESM2 of Establishing content validity for a conceptualized instrument to measure barriers to eating a healthful diet in adults: a consensus approach

description: Additional file 2: Task spreadsheet with list of identified items assigned to TDF domains. Excel spreadsheet containing the task performed by expert reviewers.
DOI: 10.6084/m9.figshare.11635056.v1
title: MOESM2 of Establishing content validity for a conceptualized instrument to measure barriers to eating a healthful diet in adults: a consensus approach

description: Additional file 2: Task spreadsheet with list of identified items assigned to TDF domains. Excel spreadsheet containing the task performed by expert reviewers.
DOI: 10.6084/m9.figshare.11635035
title: MOESM2 of A comparative study on predicting influenza outbreaks using different feature spaces: application of influenza-like illness data from Early Warning Alert and Response System in Syria

description: Additional file 2. Dataset used in manuscript. .csv file contains the EWARS data about ILI in SYRIA from the first week of 2014 to the the 42nd week of 2018.
DOI: 10.6084/m9.figshare.11635029
title: Additional file 2 of Maternal blood folate status during early pregnancy and occurrence of autism spectrum disorder in offspring: a study of 62 serum biomarkers

description: Additional file 2: Figure S2. Associations between sampling year and studied biomarkers. The smooth line was fitted with loess. a All participants. b Case group. c Control group.
DOI: 10.6084/m9.figshare.11635035.v1
title: MOESM2 of A comparative study on predicting influenza outbreaks using different feature spaces: application of influenza-like illness data from Early Warning Alert and Response System in Syria

description: Additional file 2. Dataset used in manuscript. .csv file contains the EWARS data about ILI in SYRIA from the first week of 2014 to the the 42nd week of 2018.
DOI: 10.17876/plate/dr.3/plates/203_31766
title: Digital object identifier (DOI) for the plate 31766 in archive 203 from the APPLAUSE DR3
DOI: 10.17876/plate/dr.3/plates/203_31767
title: Digital object identifier (DOI) for the plate 31767 in archive 203 from the APPLAUSE DR3
DOI: 10.17876/plate/dr.3/plates/203_31768
title: Digital object identifier (DOI) for the plate 31768 in archive 203 from the APPLAUSE DR3
DOI: 10.17876/plate/dr.3/plates/203_31769
title: Digital object identifier (DOI) for the plate 31769 in archive 203 from the APPLAUSE DR3
DOI: 10.17876/plate/dr.3/plates/203_31770
title: Digital object identifier (DOI) for the plate 31770 in archive 203 from the APPLAUSE DR3
DOI: 10.17876/plate/dr.3/plates/203_31771
title: Digital object identifier (DOI) for the plate 31771 in archive 203 from the APPLAUSE DR3
DOI: 10.17876/plate/dr.3/plates/203_31772
title: Digital object identifier (DOI) for the plate 31772 in archive 203 from the APPLAUSE DR3
DOI: 10.17876/plate/dr.3/plates/203_31773
title: Digital object identifier (DOI) for the plate 31773 in archive 203 from the APPLAUSE DR3
DOI: 10.17876/plate/dr.3/plates/203_31774
title: Digital object identifier (DOI) for the plate 31774 in archive 203 from the APPLAUSE DR3
DOI: 10.17876/plate/dr.3/plates/203_31775
title: Digital object identifier (DOI) for the plate 31775 in archive 203 from the APPLAUSE DR3
DOI: 10.17876/plate/dr.3/plates/203_31776
title: Digital object identifier (DOI) for the plate 31776 in archive 203 from the APPLAUSE DR3
DOI: 10.17876/plate/dr.3/plates/203_31777
title: Digital object identifier (DOI) for the plate 31777 in archive 203 from the APPLAUSE DR3
DOI: 10.17876/plate/dr.3/plates/203_31778
title: Digital object identifier (DOI) for the plate 31778 in archive 203 from the APPLAUSE DR3
DOI: 10.17876/plate/dr.3/plates/203_31779
title: Digital object identifier (DOI) for the plate 31779 in archive 203 from the APPLAUSE DR3
DOI: 10.17876/plate/dr.3/plates/203_31780
title: Digital object identifier (DOI) for the plate 31780 in archive 203 from the APPLAUSE DR3
DOI: 10.17876/plate/dr.3/plates/203_31781
title: Digital object identifier (DOI) for the plate 31781 in archive 203 from the APPLAUSE DR3
DOI: 10.17876/plate/dr.3/plates/203_31782
title: Digital object identifier (DOI) for the plate 31782 in archive 203 from the APPLAUSE DR3
DOI: 10.17876/plate/dr.3/plates/203_31783
title: Digital object identifier (DOI) for the plate 31783 in archive 203 from the APPLAUSE DR3
DOI: 10.17876/plate/dr.3/plates/203_31784
title: Digital object identifier (DOI) for the plate 31784 in archive 203 from the APPLAUSE DR3
DOI: 10.17876/plate/dr.3/plates/203_31785
title: Digital object identifier (DOI) for the plate 31785 in archive 203 from the APPLAUSE DR3
DOI: 10.17876/plate/dr.3/plates/203_31786
title: Digital object identifier (DOI) for the plate 31786 in archive 203 from the APPLAUSE DR3
DOI: 10.17876/plate/dr.3/plates/203_31787
title: Digital object identifier (DOI) for the plate 31787 in archive 203 from the APPLAUSE DR3
DOI: 10.17876/plate/dr.3/plates/203_31788
title: Digital object identifier (DOI) for the plate 31788 in archive 203 from the APPLAUSE DR3
DOI: 10.17876/plate/dr.3/plates/203_31789
title: Digital object identifier (DOI) for the plate 31789 in archive 203 from the APPLAUSE DR3
DOI: 10.17876/plate/dr.3/plates/203_31790
title: Digital object identifier (DOI) for the plate 31790 in archive 203 from the APPLAUSE DR3
DOI: 10.17876/plate/dr.3/plates/203_31791
title: Digital object identifier (DOI) for the plate 31791 in archive 203 from the APPLAUSE DR3
DOI: 10.17876/plate/dr.3/plates/203_31792
title: Digital object identifier (DOI) for the plate 31792 in archive 203 from the APPLAUSE DR3
DOI: 10.17876/plate/dr.3/plates/203_31793
title: Digital object identifier (DOI) for the plate 31793 in archive 203 from the APPLAUSE DR3
DOI: 10.17876/plate/dr.3/plates/203_31794
title: Digital object identifier (DOI) for the plate 31794 in archive 203 from the APPLAUSE DR3
DOI: 10.17876/plate/dr.3/plates/203_31795
title: Digital object identifier (DOI) for the plate 31795 in archive 203 from the APPLAUSE DR3
DOI: 10.17876/plate/dr.3/plates/203_31796
title: Digital object identifier (DOI) for the plate 31796 in archive 203 from the APPLAUSE DR3
DOI: 10.17876/plate/dr.3/plates/203_31797
title: Digital object identifier (DOI) for the plate 31797 in archive 203 from the APPLAUSE DR3
DOI: 10.17876/plate/dr.3/plates/203_31798
title: Digital object identifier (DOI) for the plate 31798 in archive 203 from the APPLAUSE DR3