cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.8976968.v1
title: Supplementary Material for: Predictors of 90-Day Restart of Renal Replacement Therapy after Discontinuation of Continuous Renal Replacement Therapy, a Prospective Multicenter Study

description: <b><i>Background:</i></b> Restart of renal replacement therapy (RRT) after initial discontinuation of continuous RRT (CRRT) is frequently needed. The aim of the present study was to evaluate whether renal markers after discontinuation of CRRT can predict restart of RRT within 90 days. <b><i>Methods:</i></b> Prospective multicenter observational study in 90 patients, alive, still on the intensive care unit at day 2 after discontinuation of CRRT for expected recovery with urinary neutrophil gelatinase-associated lipocalin (NGAL) available. The endpoint was restart of RRT within 90 days. Baseline and renal characteristics were compared between outcome groups no restart or restart of RRT. Logistic regression and receiver operator characteristic curve analysis were performed to determine the best predictive and discriminative variables. <b><i>Results:</i></b> Restart of RRT was needed in 32/90 (36%) patients. Compared to patients not restarting, patients restarting RRT demonstrated a higher day 2 urinary NGAL, lower day 2 urine output, and higher incremental creatinine ratio (day 2/0). In multivariate analysis, only incremental creatinine ratio (day 2/0) remained independently associated with restart of RRT (OR 5.28, 95% CI 1.45–19.31, <i>p</i> = 0.012). The area under curve for incremental creatinine ratio to discriminate for restart of RRT was 0.76 (95% CI 0.64–0.88). The optimal cutoff was 1.49 (95% CI 1.44–1.62). <b><i>Conclusion:</i></b> In this prospective multicenter study, incremental creatinine ratio (day 2/0) was the best predictor for restart of RRT. Patients with an incremental creatinine ratio at day 2 of 1.5 times creatinine at discontinuation are likely to need RRT within 90 days. These patients might benefit from nephrological follow-up.
DOI: 10.6084/m9.figshare.8977046.v3
title: Secondary structures of rfam group II introns

description: Structures of introns group II of RFAM RF00029 family
DOI: 10.6084/m9.figshare.8977046.v5
title: Secondary structures of rfam group II introns

description: Structures of eukaryotic group II introns of RFAM RF00029 family
DOI: 10.6084/m9.figshare.8976842
title: apecific binding Figure S1

description: data for Figure S1 tagPAINT
DOI: 10.6084/m9.figshare.8976842.v1
title: apecific binding Figure S1

description: data for Figure S1 tagPAINT
DOI: 10.6084/m9.figshare.8977046.v4
title: Secondary structures of rfam group II introns

description: Structures of introns group II of RFAM RF00029 family
DOI: 10.6084/m9.figshare.8976794
title: tagPAINT imaging Figure 1

description: Data from Figure 1 tagPAINT. Data are .csv files used to convolve images in ThunderSTORM. Localisation precision data for Figure S2 are also taken from here.
DOI: 10.6084/m9.figshare.8976791
title: exchange tagPAINT Figure 2

description: LAT and CD3zeta channels from exchange tagPAINT from figure 2.<br>Data are the .csv used for convolution in ThunderSTORM
DOI: 10.6084/m9.figshare.8976791.v1
title: exchange tagPAINT Figure 2

description: LAT and CD3zeta channels from exchange tagPAINT from figure 2.<br>Data are the .csv used for convolution in ThunderSTORM
DOI: 10.6084/m9.figshare.8976719
title: Targeted Metabolic Screening in DCM

description: A total of 149 metabolites were targetedly measured in non-fasting plasma and/or spot urine samples of 273 non-ischemic dilated cardiomyopathy (DCM) patients (anonymized) with different stages of disease.
DOI: 10.6084/m9.figshare.8976719.v1
title: Targeted Metabolic Screening in DCM

description: A total of 149 metabolites were targetedly measured in non-fasting plasma and/or spot urine samples of 273 non-ischemic dilated cardiomyopathy (DCM) patients (anonymized) with different stages of disease.
DOI: 10.6084/m9.figshare.8976686
title: Supplementary Material for: Overcoming Tamoxifen Resistance by Regulation of Del-1 in Breast Cancer

description: <b><i>Background:</i></b> Hormone receptor-positive breast cancer accounts for nearly two-thirds of breast cancer cases; it ultimately acquires resistance during endocrine treatment and becomes more aggressive. This study evaluated the role of developmental endothelial locus (Del)-1 in tamoxifen-resistant (TAM-R) breast cancer. <b><i>Methods:</i></b> Del-1 expression in recurrent TAM-R breast cancer tissue was evaluated and compared to that in the original tumor tissue from the same patients. Del-1 expression was also evaluated in TAM-R cells by quantitative real-time PCR, western blotting, and enzyme-linked immunosorbent assay. The effects of Del-1 knockdown on the proliferation, migration, and invasion of TAM-R cells was assessed with wound-healing and Matrigel transwell assays. <b><i>Results:</i></b> Del-1 was more highly expressed in recurrent breast cancer as compared to the original tumor tissues before initiation of endocrine treatment. Del-1 mRNA was upregulated in TAM-R and small interfering RNA-mediated knockdown of Del-1 suppressed the migration and proliferation of TAM-R cells while partly restoring TAM sensitivity. And the TAM resistance was recovered by knockdown of Del-1. <b><i>Conclusions:</i></b> TAM-R breast cancer is characterized by Del-1 overexpression and tumor progression can be inhibited by Del-1 depletion, which restores TAM sensitivity. Thus, therapeutic strategies that target Del-1 may be effective for the treatment of hormone-resistant breast cancer.
DOI: 10.6084/m9.figshare.8976686.v1
title: Supplementary Material for: Overcoming Tamoxifen Resistance by Regulation of Del-1 in Breast Cancer

description: <b><i>Background:</i></b> Hormone receptor-positive breast cancer accounts for nearly two-thirds of breast cancer cases; it ultimately acquires resistance during endocrine treatment and becomes more aggressive. This study evaluated the role of developmental endothelial locus (Del)-1 in tamoxifen-resistant (TAM-R) breast cancer. <b><i>Methods:</i></b> Del-1 expression in recurrent TAM-R breast cancer tissue was evaluated and compared to that in the original tumor tissue from the same patients. Del-1 expression was also evaluated in TAM-R cells by quantitative real-time PCR, western blotting, and enzyme-linked immunosorbent assay. The effects of Del-1 knockdown on the proliferation, migration, and invasion of TAM-R cells was assessed with wound-healing and Matrigel transwell assays. <b><i>Results:</i></b> Del-1 was more highly expressed in recurrent breast cancer as compared to the original tumor tissues before initiation of endocrine treatment. Del-1 mRNA was upregulated in TAM-R and small interfering RNA-mediated knockdown of Del-1 suppressed the migration and proliferation of TAM-R cells while partly restoring TAM sensitivity. And the TAM resistance was recovered by knockdown of Del-1. <b><i>Conclusions:</i></b> TAM-R breast cancer is characterized by Del-1 overexpression and tumor progression can be inhibited by Del-1 depletion, which restores TAM sensitivity. Thus, therapeutic strategies that target Del-1 may be effective for the treatment of hormone-resistant breast cancer.
DOI: 10.6084/m9.figshare.8976677
title: Triangle collaboration assessment of autophagy, ER stress and hypoxia in leukemogenesis: a bright perspective on the molecular recognition of B-ALL

description: B-lineage acute lymphoblastic leukemia (B-ALL) is the most common acute leukemia in childhood and adults, which caused by many various crystalline and unclear agents. Owning to this matter, no significant progress has been made in the patients-recovery. Recently, autophagy pathway is considered as an ambiguous agent in leukemia evaluation. We aim to discover the expression levels of upstream autophagy-regulating genes in newly diagnosed B-ALL patients. In B-ALL group, <i>BECN1</i>, <i>HIF1A</i> and <i>ERN1</i> expressions were significantly down-regulated, while <i>BCL2</i> expression was up-regulated compared to the control group (<i>p</i> BECN1 compared with Hypoxia and endoplasmic reticulum (ER) stress-related genes expression in the patients (<i>p</i> ERN1 and ER stress pathway-related genes could be effective regulators of autophagy in B-ALL. More investigation is recommended to gain a deeper understanding into molecular pathophysiology of B-ALL to improve treatment and monitoring approaches in affected patients.
DOI: 10.6084/m9.figshare.8976683
title: Evaluation of renal function equations to predict amikacin clearance

description: <b>Objective</b>: To evaluate the predictive performance of eight renal function equations to describe amikacin elimination in a large standard population with a wide range of age. <b>Methods</b>: Retrospective study of adult hospitalized patients treated with amikacin and monitored in the clinical pharmacokinetics laboratory of a pharmacy service. Renal function was calculated as Cockcroft-Gault with total, adjusted and ideal body weight, MDRD-4, CKD-EPI, rLM, BIS1, and FAS. One compartment model with first-order elimination, including interindividual variability on clearance and volume of distribution and combined residual error model was selected as a base structural model. A pharmaco-statistical analysis was performed following a non-linear mixed effects modeling approach (NONMEM 7.3 software). <b>Results</b>: 198 patients (61 years [18–93]) and 566 measured amikacin plasma concentrations were included. All the estimated glomerular filtration rate and creatinine clearance equations evaluated described properly the data. The linear relationship between clearance and glomerular filtration rate based on rLM showed a statistically significant improvement in the fit of the data. rLM must be evaluated carefully in renal failure for amikacin dose adjustment. <b>Conclusions</b>: Revised Lund-Malmö (rLM) and CKD-EPI showed the superior predictive performance of amikacin drug elimination comparing to all the alternative metrics evaluated.
DOI: 10.6084/m9.figshare.8976677.v1
title: Triangle collaboration assessment of autophagy, ER stress and hypoxia in leukemogenesis: a bright perspective on the molecular recognition of B-ALL

description: B-lineage acute lymphoblastic leukemia (B-ALL) is the most common acute leukemia in childhood and adults, which caused by many various crystalline and unclear agents. Owning to this matter, no significant progress has been made in the patients-recovery. Recently, autophagy pathway is considered as an ambiguous agent in leukemia evaluation. We aim to discover the expression levels of upstream autophagy-regulating genes in newly diagnosed B-ALL patients. In B-ALL group, <i>BECN1</i>, <i>HIF1A</i> and <i>ERN1</i> expressions were significantly down-regulated, while <i>BCL2</i> expression was up-regulated compared to the control group (<i>p</i> BECN1 compared with Hypoxia and endoplasmic reticulum (ER) stress-related genes expression in the patients (<i>p</i> ERN1 and ER stress pathway-related genes could be effective regulators of autophagy in B-ALL. More investigation is recommended to gain a deeper understanding into molecular pathophysiology of B-ALL to improve treatment and monitoring approaches in affected patients.
DOI: 10.6084/m9.figshare.8976683.v1
title: Evaluation of renal function equations to predict amikacin clearance

description: <b>Objective</b>: To evaluate the predictive performance of eight renal function equations to describe amikacin elimination in a large standard population with a wide range of age. <b>Methods</b>: Retrospective study of adult hospitalized patients treated with amikacin and monitored in the clinical pharmacokinetics laboratory of a pharmacy service. Renal function was calculated as Cockcroft-Gault with total, adjusted and ideal body weight, MDRD-4, CKD-EPI, rLM, BIS1, and FAS. One compartment model with first-order elimination, including interindividual variability on clearance and volume of distribution and combined residual error model was selected as a base structural model. A pharmaco-statistical analysis was performed following a non-linear mixed effects modeling approach (NONMEM 7.3 software). <b>Results</b>: 198 patients (61 years [18–93]) and 566 measured amikacin plasma concentrations were included. All the estimated glomerular filtration rate and creatinine clearance equations evaluated described properly the data. The linear relationship between clearance and glomerular filtration rate based on rLM showed a statistically significant improvement in the fit of the data. rLM must be evaluated carefully in renal failure for amikacin dose adjustment. <b>Conclusions</b>: Revised Lund-Malmö (rLM) and CKD-EPI showed the superior predictive performance of amikacin drug elimination comparing to all the alternative metrics evaluated.
DOI: 10.6084/m9.figshare.8976662
title: Supplementary Material for: Application of an Easy-to-Perform High-Energy and Low-End Visible Light Transmittance Method and the Influence of Tinted Sunscreens on High-Energy/Low-End Visible Light Transmittance and Infrared Protection

description: <b><i>Background:</i></b> About 50% of the sun’s radiation arriving on earth is visible light (VIS). For a long time, its effects on human health have not been fully investigated. But recently, the influence of VIS has gained more attention, especially regarding skin physiology. Studies showed various effects, many of them harmful, comparable to UV radiation. As a result, there are now a few sunscreens commercially available which claim protection against VIS. The question of whether protection is necessary is still much discussed. <b><i>Aims:</i></b> The objective of this study was to develop an easy-to-perform high-energy visible (HEV) and low-end visible (LEV) light transmittance method to determine the direct VIS protection of sunscreens and other cosmetic samples. Furthermore, the influence of the brightness of the tested products on the HEV, LEV, and infrared A protection was investigated. <b><i>Methods:</i></b> An experimental setup consisting of a light source, a VIS-transmissible filter system, and a sensor unit was built to measure the direct VIS protection of sunscreens and other daily skin care products in two ranges of the VIS area. For a closer look, the brightness of the samples was evaluated by photometric assessment. <b><i>Results/Conclusion:</i></b> The experimental setup could be validated. It could be demonstrated for the first time that there is a strong positive linear correlation between transmittance and brightness of tinted sunscreen and daily skin care products with sunscreen properties in the HEV, LEV, and infrared A range. However, tinted samples worked best in the blue light region, and the higher the wavelength range, the lower the protection.
DOI: 10.6084/m9.figshare.8976602
title: Supplementary Material for: Identifying Perceptions and Preferences of the General Public Concerning Universal Screening of Children for Familial Hypercholesterolaemia

description: <b><i>Background/Aims:</i></b> Familial hypercholesterolaemia (FH) is a common genetic disorder that, if untreated, predisposes individuals to premature coronary heart disease. As most individuals with FH remain undiagnosed, new approaches to detection are needed and should be considered a priority in public health genomics. Universal screening of children for FH has been proposed, and this study explores public perspectives on the acceptability of this approach. <b><i>Methods:</i></b> A one-day deliberative public forum was held in Perth, WA, Australia. Thirty randomly selected individuals were recruited, with self-reported sociodemographic characteristics used to obtain discursive representation. Participants were presented with information from a variety of perspectives and asked to discuss the information provided to identify points of consensus and disagreement. The data collected were analysed using thematic analysis. <b><i>Results:</i></b> Of the 17 participants at the forum, 16 deemed universal screening of children for FH to be acceptable. Fifteen of these 16 believed this was best performed at the time of an immunisation. Participants proposed a number of conditions that should be met to reduce the likelihood of unintended harm resulting from the screening process. <b><i>Discussion/Conclusion:</i></b> The outcomes of the forum suggest that establishing a universal screening programme for FH in childhood is acceptable to the general public in WA.
DOI: 10.6084/m9.figshare.8976581
title: Synergistic antibacterial activity of silver nanoparticles and hydrogen peroxide.xlsx

description: Data for manuscript entitled "Synergistic antibacterial activity of silver nanoparticles and hydrogen peroxide" (DOI: 10.1371/journal.pone.0220575)
DOI: 10.6084/m9.figshare.8976581.v1
title: Synergistic antibacterial activity of silver nanoparticles and hydrogen peroxide.xlsx

description: Data for manuscript entitled "Synergistic antibacterial activity of silver nanoparticles and hydrogen peroxide" (DOI: 10.1371/journal.pone.0220575)
DOI: 10.6084/m9.figshare.8976422
title: Observation of rapid seabed erosion near closure depth during a storm period at Hujeong Beach, South Korea

description: Observation data used for creating figures in the paper 'Observation of rapid seabed erosion near closure depth during a storm period at Hujung Beach, South Korea'
DOI: 10.1184/r1/8976410
title: Supplementary Material for Spherical Indexing of Complex Microstructures paper

description: Two experimental EBSD data sets acquired at the Universite de Lorraine, France, along with data analysis using the commercial indexing software as well as a new spherical indexing approach. All input and output files from the data analysis are made available.
DOI: 10.1184/r1/8976410.v1
title: Supplementary Material for Spherical Indexing of Complex Microstructures paper

description: Two experimental EBSD data sets acquired at the Universite de Lorraine, France, along with data analysis using the commercial indexing software as well as a new spherical indexing approach. All input and output files from the data analysis are made available.
DOI: 10.6084/m9.figshare.8976401
title: Supplementary Material for: A Systematic Review of Substance Use (Disorder) in Individuals with Mild to Borderline Intellectual Disability

description: Although the attention for substance use (SU) and SU disorders (SUD) among individuals with mild to borderline intellectual disability (MBID) has been growing exponentially, this form of dual diagnosis has largely been ignored by addiction medicine. In this article, we systematically review the research between January 2000 and June 2018 on the prevalence, assessment, and treatment of SU(D) among children, adolescents, and adults with MBID. A total of 138 articles were included. It is concluded that individuals with MBID are likely to be at a higher risk for developing SUD compared to those without MBID. Future research should focus on the detection of MBID among patients being treated in addiction medicine, the development and implementation of systematic assessment methods of SU(D) among individuals with MBID, and the development and evaluation of prevention and treatment interventions. System integration, interdisciplinary collaboration, and the development of tailored treatment for individuals with MBID are advised to improve treatment access and outcome for those who have developed SUD.
DOI: 10.6084/m9.figshare.8976422.v2
title: Observation of rapid seabed erosion near closure depth during a storm period at Hujeong Beach, South Korea

description: Observation data used for creating figures in the paper 'Observation of rapid seabed erosion near closure depth during a storm period at Hujung Beach, South Korea'
DOI: 10.6084/m9.figshare.8976401.v1
title: Supplementary Material for: A Systematic Review of Substance Use (Disorder) in Individuals with Mild to Borderline Intellectual Disability

description: Although the attention for substance use (SU) and SU disorders (SUD) among individuals with mild to borderline intellectual disability (MBID) has been growing exponentially, this form of dual diagnosis has largely been ignored by addiction medicine. In this article, we systematically review the research between January 2000 and June 2018 on the prevalence, assessment, and treatment of SU(D) among children, adolescents, and adults with MBID. A total of 138 articles were included. It is concluded that individuals with MBID are likely to be at a higher risk for developing SUD compared to those without MBID. Future research should focus on the detection of MBID among patients being treated in addiction medicine, the development and implementation of systematic assessment methods of SU(D) among individuals with MBID, and the development and evaluation of prevention and treatment interventions. System integration, interdisciplinary collaboration, and the development of tailored treatment for individuals with MBID are advised to improve treatment access and outcome for those who have developed SUD.
DOI: 10.6084/m9.figshare.8976422.v1
title: Observation of rapid seabed erosion near closure depth during a storm period at Hujeong Beach, South Korea

description: Observation data used for creating figures in the paper 'Observation of rapid seabed erosion near closure depth during a storm period at Hujung Beach, South Korea'
DOI: 10.6084/m9.figshare.8976116
title: Revision of the subfamily Pitarinae Stewart, 1930 (<i>Eucallista</i> Dall, 1902; <i>Austrocallista</i> Erdmann & Morra, 1985; <i>Proteopitar</i> gen. nov.) from Cenozoic southern South America: systematic and phylogenetic analyses

description: Systematic and phylogenetic analyses of fossil and extant Pitarinae of the South-Western Atlantic Ocean and Chile have been performed. The group is represented by <i>Eucallista</i> Dall, 1902 (early Miocene–Recent), <i>Austrocallista</i> Erdmann & Morra, 1985 (Eocene–Pliocene) and <i>Proteopitar</i> gen. nov. (middle Miocene–Recent). <i>Eucallista</i> and <i>Austrocallista</i> have sculptured nymphs and include species previously assigned to <i>Amiantis</i> Carpenter, 1864. <i>Eucallista</i> is represented by three species: the extant <i>E. purpurata</i> (Lamarck, 1818) (Pleistocene–Recent, South-Western Atlantic Ocean from Golfo San Matías [Argentina] to Espirito Santo [Brazil]) and two fossil taxa, <i>E. laziarina</i> (Ihering, 1907) from the Miocene and Pliocene of Chile, Argentina and Uruguay, and <i>E. domeykoana</i> (Philippi, 1887) from the Miocene and Pliocene of Chile and Peru. <i>Austrocallista</i> has four taxa: <i>Austrocallista</i> sp. from the Eocene of Santa Cruz Province, <i>A. iheringi</i> (Cossmann, 1898) from the late Oligocene–middle Miocene of Patagonia, <i>A. australis</i> (Feruglio, 1935) (lectotype MGGC 607) from the early Miocene of Santa Cruz Province, and <i>A. boliviana</i> (Philippi, 1887) from the Miocene and Pliocene of Chile and Peru. <i>Proteopitar</i> gen. nov. is erected to incorporate two species previously assigned to <i>Pitar</i> Römer, 1857: <i>Proteopitar mutabilis</i> (del Río & Martínez, 1998) from the middle Miocene–late Miocene of Argentina and the Pleistocene–Recent species <i>Proteopitar patagonicus</i> (d’Orbigny, 1835–1847) (from Rio de Janeiro [Brazil] to Bahía Vera [Chubut, Argentina]). These systematic hypotheses are corroborated by the phylogenetic analysis performed, which is the first one of the subfamily that includes fossil and extant taxa based on morphological characters of the shell. In addition, a new site on the coast of Río Negro Province which contains shells of the extant species is dated as 830 Ka BP (MIS21), being the oldest record of both extant species. http://www.zoobank.org/urn:lsid:zoobank.org:pub:16519263-4F9E-41AB-A009-EAC030681826