cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.22828223.v1
title: Cytotoxicity and genotoxicity of Bio-C Repair, Endosequence BC Root Repair, MTA Angelus and MTA Repair HP

description: Abstract The aim was to evaluate in vitro cytotoxicity and genotoxicity of Bio-C Repair (BCR), compared to Endosequence BC Root Repair (ERRM), MTA Angelus (MTA-Ang), and MTA Repair HP (MTA-HP). MC3T3 osteoblastic cells were exposed to extracts of the repairing bioceramic cements. After 1, 3, and 7 days, cytotoxicity and genotoxicity were evaluated by MTT and Micronucleus tests, respectively. Cells not exposed to biomaterials were used as a negative control. Data were compared using ANOVA two-way, followed by the Tukey Test (α=5%). MTA-Ang and MTA-HP showed no difference in relation to control regarding cytotoxicity in any experimental times. BCR and ERRM reduced cell viability after 3 and 7 days (p&lt;0.05); however, the reduction caused by BCR was less than that caused by ERRM. Considering the micronucleus formation, all biomaterials caused an increase after 3 and 7 days (p&lt;0.05), being greater for the BCR and ERRM groups. It can be concluded that BCR is non-cytotoxic in osteoblastic cells, as well as MTA-Ang e MTA Repair HP. BCR and ERRM showed greater genotoxicity than others tested biomaterials.
DOI: 10.6084/m9.figshare.22828229
title: Impact of reference diet composition on apparent digestibility coefficients of two protein-rich ingredients in Nile tilapia

description: ABSTRACT Protein quality is related to amino acid composition and digestibility. Accurate evaluation of apparent digestibility coefficients (ADCs) of nutrients in commonly used feedstuffs is paramount for formulating efficient aquafeed. ADCs of soybean meal (SBM) and poultry by-product meal (PBM) were evaluated using reference diets formulated with two types of ingredients (semi-purified [SP] and practical [P]) for juvenile Nile tilapia ( Oreochromis niloticus, Linnaeus) of the GIFT strain. Groups of 20 juveniles (65.05 ± 12.37 g) were fed twice a day to apparent satiety with one of the four experimental diets (SBM-SP, SBM-P, PBM-SP, and PBM-P) in quadruplicate for 30 days. After the last feeding, feces were collected by siphoning hourly and the ADCs of dry matter, protein, and amino acids (AAs) were calculated. Nile tilapia exhibited a high capacity to digest SBM and PBM, with most ADCs exceeding 90 %. The type of reference diet affected the ADCs of protein and AAs on the test ingredients, with the SP reference diet providing the highest ADC, mainly in SBM. Digestibility data generated with a P-type reference diet demonstrated more practical relevance than those generated with an SP-type reference diet. They can be applied in digestibility studies for Nile tilapia.
DOI: 10.6084/m9.figshare.22828229.v1
title: Impact of reference diet composition on apparent digestibility coefficients of two protein-rich ingredients in Nile tilapia

description: ABSTRACT Protein quality is related to amino acid composition and digestibility. Accurate evaluation of apparent digestibility coefficients (ADCs) of nutrients in commonly used feedstuffs is paramount for formulating efficient aquafeed. ADCs of soybean meal (SBM) and poultry by-product meal (PBM) were evaluated using reference diets formulated with two types of ingredients (semi-purified [SP] and practical [P]) for juvenile Nile tilapia ( Oreochromis niloticus, Linnaeus) of the GIFT strain. Groups of 20 juveniles (65.05 ± 12.37 g) were fed twice a day to apparent satiety with one of the four experimental diets (SBM-SP, SBM-P, PBM-SP, and PBM-P) in quadruplicate for 30 days. After the last feeding, feces were collected by siphoning hourly and the ADCs of dry matter, protein, and amino acids (AAs) were calculated. Nile tilapia exhibited a high capacity to digest SBM and PBM, with most ADCs exceeding 90 %. The type of reference diet affected the ADCs of protein and AAs on the test ingredients, with the SP reference diet providing the highest ADC, mainly in SBM. Digestibility data generated with a P-type reference diet demonstrated more practical relevance than those generated with an SP-type reference diet. They can be applied in digestibility studies for Nile tilapia.
DOI: 10.6084/m9.figshare.22828231.v1
title: Selection of lima bean accessions for fresh and dry production

description: ABSTRACT The selection of lima bean accessions in the fresh and dry stages is an excellent tool to increase crop yield in Brazil and ensure a source of vegetable protein for the population. Principal component analysis and nonparametric indices can be used to identify promising accessions based on the desired agronomic variables. The aim of the present study was to select accessions from traditional lima bean varieties in the fresh and dry stages using principal component analysis and nonparametric selection indices. The experiment consisted of a randomized block design, evaluating 13 treatments in four replicates. The experimental plot contained 20 plants in its study area. The first two principal components for the two stages explained more than 80% of the variation found among the accessions. The Mulamba & Mock and Genotype-Ideotype selection indices were efficient in classifying promising varieties for breeding programs. The UFPI 1111 accession can be used in fresh lima bean production, and its UFPI 1248 and 1294 counterparts in lima bean breeding programs.
DOI: 10.6084/m9.figshare.22828231
title: Selection of lima bean accessions for fresh and dry production

description: ABSTRACT The selection of lima bean accessions in the fresh and dry stages is an excellent tool to increase crop yield in Brazil and ensure a source of vegetable protein for the population. Principal component analysis and nonparametric indices can be used to identify promising accessions based on the desired agronomic variables. The aim of the present study was to select accessions from traditional lima bean varieties in the fresh and dry stages using principal component analysis and nonparametric selection indices. The experiment consisted of a randomized block design, evaluating 13 treatments in four replicates. The experimental plot contained 20 plants in its study area. The first two principal components for the two stages explained more than 80% of the variation found among the accessions. The Mulamba & Mock and Genotype-Ideotype selection indices were efficient in classifying promising varieties for breeding programs. The UFPI 1111 accession can be used in fresh lima bean production, and its UFPI 1248 and 1294 counterparts in lima bean breeding programs.
DOI: 10.6084/m9.figshare.22828234
title: In-Vitro and Ex-Vivo Evaluation of Transfersomal Gel of Methotrexate

description: Abstract Methotrexate on its oral and intravenous administration results in unwanted adverse effects. This drawback can be overcome by transdermal delivery because of its painless objective for systemic drug administration. Transfersomes are ultra-deformable vesicles with the flexibility to reach deeper tissues of the skin. The objective of this research work was to develop methotrexate transfersomal gel by thin film hydration technique, evaluated for entrapment efficiency, deformability, mean vesicle size, and stability, and incorporated into carbopol gel for ease of handling and skin applicability for a longer period of retention on skin. MTX-TFS gel & conventional gel were characterized for consistency, transparency, viscosity, and pH. Ex-vivo skin permeation studies were performed using abdominal goat skin and drug release kinetic parameters and transdermal flux were calculated using mathematical models. The results indicate that MTX was successfully entrapped (84.77 ± 2.35 %w/w) in transfersomes having 240±1.6 nm vesicle sizes and 27.13±0.7 deformability index. The gel was permeated through the skin at a rate of 28.12±2.58 µg/cm2/hr as compared to the conventional gel (10.35±2.14 µg/cm2/ hr). From the study, it was concluded that the MTX-TFS gel can be used as a possible substitute for the conventional formulation for transdermal drug delivery due to 3 times improvement in transdermal flux.
DOI: 10.6084/m9.figshare.22828234.v1
title: In-Vitro and Ex-Vivo Evaluation of Transfersomal Gel of Methotrexate

description: Abstract Methotrexate on its oral and intravenous administration results in unwanted adverse effects. This drawback can be overcome by transdermal delivery because of its painless objective for systemic drug administration. Transfersomes are ultra-deformable vesicles with the flexibility to reach deeper tissues of the skin. The objective of this research work was to develop methotrexate transfersomal gel by thin film hydration technique, evaluated for entrapment efficiency, deformability, mean vesicle size, and stability, and incorporated into carbopol gel for ease of handling and skin applicability for a longer period of retention on skin. MTX-TFS gel & conventional gel were characterized for consistency, transparency, viscosity, and pH. Ex-vivo skin permeation studies were performed using abdominal goat skin and drug release kinetic parameters and transdermal flux were calculated using mathematical models. The results indicate that MTX was successfully entrapped (84.77 ± 2.35 %w/w) in transfersomes having 240±1.6 nm vesicle sizes and 27.13±0.7 deformability index. The gel was permeated through the skin at a rate of 28.12±2.58 µg/cm2/hr as compared to the conventional gel (10.35±2.14 µg/cm2/ hr). From the study, it was concluded that the MTX-TFS gel can be used as a possible substitute for the conventional formulation for transdermal drug delivery due to 3 times improvement in transdermal flux.
DOI: 10.5281/zenodo.7758208
title: Supplemetary Data for the article: Machine-learning identified molecular fragments responsible for infrared emission features of polycyclic aromatic hydrocarbons

description: This is a set of Supplementary materials for the article 'Machine-learning identified molecular fragments responsible for infrared emission features of polycyclic aromatic hydrocarbons', by Meng et al. Supplementary_Data_I.pdf contains an extensive table spanning 36 pages that lists the top-10 molecular fragments accountable for the spectral bands between 2.761 and 1172.745 μm. To access this table, hyperlinks within the document can be used for navigation. Supplementary_Data_II.pdf comprises a large table that encompasses 10,691 pages, including the top-100 molecular fragments responsible for the spectral bands between 2.761 and 1172.745 μm. Navigation through the hyperlinks enables access to this table. Supplementary_Data_III.csv encompasses the chemical formulas, number of unpaired valence electrons, spin multiplicities, xyz data, and SMILES strings of the PAHs carrying the additional spectra. Supplementary_data_IV.zip includes the input and output datasets along with the ML code. The code script is written in Python 3.7, and is supported by the following libraries: sklearn, json, numpy, and pandas. Supplementary_Information.pdf contains the evidence supporting the choice of the cutoff radius, as well as the figures of the count of the molecules in the dataset, the FI with changing datasets and hyperparameters, of cross-validation, and of UIE bands and emission features of four SH PAHs. Importance of three carbon skeleton fragments for bands in different intervals is also demonstrated.
DOI: 10.5281/zenodo.7758209
title: Supplemetary Data for the article: Machine-learning identified molecular fragments responsible for infrared emission features of polycyclic aromatic hydrocarbons

description: This is a set of Supplementary materials for the article 'Machine-learning identified molecular fragments responsible for infrared emission features of polycyclic aromatic hydrocarbons', by Meng et al. Supplementary_Data_I.pdf contains an extensive table spanning 36 pages that lists the top-10 molecular fragments accountable for the spectral bands between 2.761 and 1172.745 μm. To access this table, hyperlinks within the document can be used for navigation. Supplementary_Data_II.pdf comprises a large table that encompasses 10,691 pages, including the top-100 molecular fragments responsible for the spectral bands between 2.761 and 1172.745 μm. Navigation through the hyperlinks enables access to this table. Supplementary_Data_III.csv encompasses the chemical formulas, number of unpaired valence electrons, spin multiplicities, and SMILES strings of the PAHs carrying the additional spectra. Supplementary_data_IV.zip includes the input and output datasets along with the ML code. The code script is written in Python 3.7, and is supported by the following libraries: sklearn, json, numpy, and pandas. Supplementary_Information.pdf contains the evidence supporting the choice of the cutoff radius, as well as the figures of the count of the molecules in the dataset, the FI with changing datasets and hyperparameters, of cross-validation, and of UIE bands and emission features of four SH PAHs.
DOI: 10.5281/zenodo.7873339
title: Supplemetary Data for the article: Machine-learning identified molecular fragments responsible for infrared emission features of polycyclic aromatic hydrocarbons

description: This is a set of Supplementary materials for the article 'Machine-learning identified molecular fragments responsible for infrared emission features of polycyclic aromatic hydrocarbons', by Meng et al. Supplementary_Data_I.pdf contains an extensive table spanning 36 pages that lists the top-10 molecular fragments accountable for the spectral bands between 2.761 and 1172.745 μm. To access this table, hyperlinks within the document can be used for navigation. Supplementary_Data_II.pdf comprises a large table that encompasses 10,691 pages, including the top-100 molecular fragments responsible for the spectral bands between 2.761 and 1172.745 μm. Navigation through the hyperlinks enables access to this table. Supplementary_Data_III.csv encompasses the chemical formulas, number of unpaired valence electrons, spin multiplicities, xyz data, and SMILES strings of the PAHs carrying the additional spectra. Supplementary_data_IV.zip includes the input and output datasets along with the ML code. The code script is written in Python 3.7, and is supported by the following libraries: sklearn, json, numpy, and pandas. Supplementary_Information.pdf contains the evidence supporting the choice of the cutoff radius, as well as the figures of the count of the molecules in the dataset, the FI with changing datasets and hyperparameters, of cross-validation, and of UIE bands and emission features of four SH PAHs.
DOI: 10.5281/zenodo.7939919
title: Supplemetary Data for the article: Machine-learning identified molecular fragments responsible for infrared emission features of polycyclic aromatic hydrocarbons

description: This is a set of Supplementary materials for the article 'Machine-learning identified molecular fragments responsible for infrared emission features of polycyclic aromatic hydrocarbons', by Meng et al. Supplementary_Data_I.pdf contains an extensive table spanning 36 pages that lists the top-10 molecular fragments accountable for the spectral bands between 2.761 and 1172.745 μm. To access this table, hyperlinks within the document can be used for navigation. Supplementary_Data_II.pdf comprises a large table that encompasses 10,691 pages, including the top-100 molecular fragments responsible for the spectral bands between 2.761 and 1172.745 μm. Navigation through the hyperlinks enables access to this table. Supplementary_Data_III.csv encompasses the chemical formulas, number of unpaired valence electrons, spin multiplicities, xyz data, and SMILES strings of the PAHs carrying the additional spectra. Supplementary_data_IV.zip includes the input and output datasets along with the ML code. The code script is written in Python 3.7, and is supported by the following libraries: sklearn, json, numpy, and pandas. Supplementary_Information.pdf contains the evidence supporting the choice of the cutoff radius, as well as the figures of the count of the molecules in the dataset, the FI with changing datasets and hyperparameters, of cross-validation, and of UIE bands and emission features of four SH PAHs. Importance of three carbon skeleton fragments for bands in different intervals is also demonstrated.
DOI: 10.6084/m9.figshare.22828235.v1
title: Rural internship in medical schools in Brazil

description: Abstract: Introduction: The consolidation of rural internship programs is not a simple phenomenon, although its importance is currently recognized by students and teachers as a differentiated activity in their training itineraries. Medical schools still face considerable challenges in carrying out this type of activity. The existence of evidence that recruiting students to rural internships, offering meaningful experiences during undergraduate school and implementing a specific training program for rural areas after graduation, are the most effective interventions for recruitment and retention. Objective: Identify the rural internship programs in operation in Brazil, through the evaluation of Curricular Pedagogical Projects (PPCs,) of medical courses, fostering the debate on medical training for rural and remote areas, as well as emphasizing the importance of this type of training. Method: Cross-sectional, descriptive and documentary analysis study, with a quantitative characteristic, with a sampling of the access to the Curricular Pedagogical Projects (PPCs) of medical schools in Brazil with rural internships in the curriculum. Result: Of the 357 Medical Schools in Brazil, the authors found 18 programs with rural internships, corresponding to 5% of the institutions. The Southeast Region, when compared to the North region, concentrates the largest number of medical schools in Brazil (148), but the largest number of PPCs with rural internship is in the North Region of Brazil, totaling 6 (16%) in relation to medical schools in the region. Furthermore, of the 47 medical schools in the Southeast Region, in Minas Gerais, 2 rural internship programs were identified by the authors, in relation to other states in the same region. Conclusion: There are few rural internship programs identified in the PPCs in Brazilian medical schools. Changes are needed in the PPCs, with the inclusion of rural internships, with the inclusion of well-defined competencies and based on people’s health needs; construction of knowledge and development of skills and attitudes to solve problems, consistent with the reality of Brazil.
DOI: 10.6084/m9.figshare.22828235
title: Rural internship in medical schools in Brazil

description: Abstract: Introduction: The consolidation of rural internship programs is not a simple phenomenon, although its importance is currently recognized by students and teachers as a differentiated activity in their training itineraries. Medical schools still face considerable challenges in carrying out this type of activity. The existence of evidence that recruiting students to rural internships, offering meaningful experiences during undergraduate school and implementing a specific training program for rural areas after graduation, are the most effective interventions for recruitment and retention. Objective: Identify the rural internship programs in operation in Brazil, through the evaluation of Curricular Pedagogical Projects (PPCs,) of medical courses, fostering the debate on medical training for rural and remote areas, as well as emphasizing the importance of this type of training. Method: Cross-sectional, descriptive and documentary analysis study, with a quantitative characteristic, with a sampling of the access to the Curricular Pedagogical Projects (PPCs) of medical schools in Brazil with rural internships in the curriculum. Result: Of the 357 Medical Schools in Brazil, the authors found 18 programs with rural internships, corresponding to 5% of the institutions. The Southeast Region, when compared to the North region, concentrates the largest number of medical schools in Brazil (148), but the largest number of PPCs with rural internship is in the North Region of Brazil, totaling 6 (16%) in relation to medical schools in the region. Furthermore, of the 47 medical schools in the Southeast Region, in Minas Gerais, 2 rural internship programs were identified by the authors, in relation to other states in the same region. Conclusion: There are few rural internship programs identified in the PPCs in Brazilian medical schools. Changes are needed in the PPCs, with the inclusion of rural internships, with the inclusion of well-defined competencies and based on people’s health needs; construction of knowledge and development of skills and attitudes to solve problems, consistent with the reality of Brazil.
DOI: 10.6084/m9.figshare.22828237
title: Evaluation of iron dextran application programs to prevent iron deficiency anemia in piglets

description: ABSTRACT To evaluate the effect of different iron dextran application programs on the performance, fecal score, and skin color of suckling piglets, as well as sow performance, 288 piglets from 24 sows were allocated to four treatments in six replications with 12 piglets per experimental unit, in a block design. The treatments were as follows: T200_000, T200_100, T200_200, and T100_100, whose respective values (in mg) corresponded to the applications of the first dose of iron dextran on the second day of life and of the second dose on the 10th day. Piglets on T200_000 and T200_200 showed the highest feed intake. In the period from 10 to 22 days, piglets receiving T100_100 exhibited the highest fecal score. On the 10th day of age, the lowest lightness (L*) value on the ear was obtained with T200_100, and the highest with T100_100. Treatments T200_000, T200_100, and T200_200 generated the highest red color (a*) intensity on the ear, whereas T100_100 provided the lowest hue and parameter b* values on the leg and snout. On the 22nd day of age, the highest b* and hue values of the ear and snout were found in the group fed T100_100. In conclusion, all evaluated programs were efficient in preventing iron deficiency anemia in newborn piglets. To reduce expenses, we recommend administering a single dose of 200 mg of iron dextran to piglets on the second day of life.
DOI: 10.6084/m9.figshare.22828237.v1
title: Evaluation of iron dextran application programs to prevent iron deficiency anemia in piglets

description: ABSTRACT To evaluate the effect of different iron dextran application programs on the performance, fecal score, and skin color of suckling piglets, as well as sow performance, 288 piglets from 24 sows were allocated to four treatments in six replications with 12 piglets per experimental unit, in a block design. The treatments were as follows: T200_000, T200_100, T200_200, and T100_100, whose respective values (in mg) corresponded to the applications of the first dose of iron dextran on the second day of life and of the second dose on the 10th day. Piglets on T200_000 and T200_200 showed the highest feed intake. In the period from 10 to 22 days, piglets receiving T100_100 exhibited the highest fecal score. On the 10th day of age, the lowest lightness (L*) value on the ear was obtained with T200_100, and the highest with T100_100. Treatments T200_000, T200_100, and T200_200 generated the highest red color (a*) intensity on the ear, whereas T100_100 provided the lowest hue and parameter b* values on the leg and snout. On the 22nd day of age, the highest b* and hue values of the ear and snout were found in the group fed T100_100. In conclusion, all evaluated programs were efficient in preventing iron deficiency anemia in newborn piglets. To reduce expenses, we recommend administering a single dose of 200 mg of iron dextran to piglets on the second day of life.