cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.25550/1ww0
title: Shapiro. Shape-Based Retrieval of 3D Craniofacial Data

description: Craniofacial malformations are among the most common structural malformations in humans. Researchers studying disorders of the craniofacial anatomy have many 3D imaging tools available to them, including computed tomography, magnetic resonance imaging, and 3D surface scans. Craniofacial researchers studying particular disorders are constructing large image databases of subjects in their studies. The FaceBase Consortium will provide a central HUB for collection of data from numerous sites, enabling studies that would otherwise not be possible. Since shape is the critical factor in the classification of most craniofacial disorders, tools for analyzing 3D shape are essential to these studies. Quantitative shape descriptors allow for reproducible shape description, while similarity-based shape retrieval allows comparisons to be made between individuals or populations. The goal of this project is to develop tools for shape-based retrieval of 3D craniofacial image data. The specific aims of the project are to: 1) develop software tools that produce quantitative representations of craniofacial anatomy that can assist in the study of mid-face hypoplasia and cleft lip and palate; 2) develop tools for quantifying the similarity of craniofacial data between two individuals, between an individual and an average over a selected population, or between two populations; 3) develop mechanisms for organization and retrieval of multimodality 3D craniofacial data based on their quantitative representations; and 4) design and implement a prototype system for Craniofacial Information Retrieval (CIR) that incorporates quantification, organization, and retrieval; evaluate it on 3D craniofacial data and make it available to the FaceBase HUB. The design of these tools and a pilot system will lead to a general methodology that is immediately applicable to studies of mid-face hypoplasia, cleft lip and cleft palate, but is also scalable and modifiable to all craniofacial abnormalities. NIDCR has awarded a supplement to this project to develop an Ontology of Craniofacial Development and Malformation (OCDM), and to demonstrate its usefulness for both the parent project and the FaceBase consortium as a whole.
DOI: 10.25550/1ww6
title: Hooper/Jones/Williams. RNA Dynamics in the Developing Mouse Face

description: Craniofacial morphogenesis is a complex process requiring coordinated proliferation, movement and differentiation of six distinct facial prominences. The complexity of this process leaves it vulnerable to environmental and genetic perturbations, such that craniofacial malformations are one of the most common classes of birth defects. Facial prominences are made up of a mono-layer of ectoderm encasing a large core of neural crest- and mesodermally-derived mesenchymal cells. Signaling from this minor population of ectodermal cells directs and coordinates the behavior of the underlying mesenchyme, and thence facial morphogenesis. Manipulations that alter these signaling processes and tissue interactions have grave consequences for facial development, resulting in various types of medically important dysmorphology including orofacial clefting. Thus a detailed knowledge of geno-dynamics of the ectoderm is an essential component of the overall description of facial development. A multi-disciplinary team has been assembled with expertise in craniofacial biology, mouse molecular genetics, bioinformatics and computer biology to gain a Systems Biology level understanding of early mammalian facial development. These combined studies should provide a valuable resource detailing the dynamic interplay of ectoderm and mesenchyme during normal facial development. **Aims** * Aim 1 The ectoderm and the mesenchyme of the wild-type facial prominences will be separated at critical timepoints encompassing facial morphogenesis. * Aim 2 These separated tissues will be used to generate contrasting dynamic spatio-temporal profiles of gene expression and post-translational RNA regulation at the level of splicing, turnover, and translation.
DOI: 10.25550/1wwc
title: Hallgrimsson/Klein/Spritz. Developing 3D Craniofacial Morphometry Data and Tools to Transform Dysmorphology

description: Dysmorphology is the branch of pediatrics and clinical genetics concerned with structural birth defects and delineation of syndromes. More than 1500 syndromes that include orofacial dysmorphia have been described. Today, dysmorphology remains largely descriptive, with diagnoses based on subjective or semi-quantitative clinical impressions of facial and other anatomic features. Over the past decade, dramatic technological advances in imaging, quantification, and analysis of variation in complex three-dimensional (3D) shape have revolutionized the assessment of morphologic variation, permitting robust definition of quantitative morphometric phenotypes that can distinguish patients from controls in a variety of syndromes. The goal of this proposal is to develop systems that will enable diagnostic application of craniofacial 3D morphometrics in clinical practice. We aim to define specific quantitative measures that characterize the aberrant facial shapes in a large number of human dysmorphic syndromes. We anticipate that 3D photomorphometric “deep-phenotyping”, in conjunction with the rapid advent of exome and genome sequencing in clinical medicine, will transform dysmorphology from a clinical art into a medical science.
DOI: 10.25550/1www
title: Hallgrimsson/Klein. Inbred Background Genetic Effects on Craniofacial Dysmorphology

description: Inbred genetic background significantly influences the expression of phenotypes associated with known genetic perturbations and can underlie variation in disease severity between individuals with the same mutation. However, the effect of epistatic interactions on the development of complex traits, such as craniofacial morphology, is poorly understood. We use the morphometric landmarks associated with a previous FaceBase analysis (Genetic Determinants of Orofacial Shape and Relationship to Cleft Lip/Palate) to 1) quantify the effect of three Sprouty null mutations on craniofacial shape and 2) to quantify how the associated dysmorphology is modulated by three inbred backgrounds. While it is commonly known that a given mutation may have different phenotypic effects across mouse backgrounds, our quantitative results represent an important first step towards elucidating genetic interactions underlying variation in robustness to known genetic perturbations in mice. Taking background effects into account will be necessary to identify genetic and developmental interactions that modulate the severity of craniofacial dysmorphology, because variation in the penetrance or severity of a disease mutation among humans is almost certainly based on similar interactions. In addition, identical micro-CT image and landmarking protocols make this a valuable comparative dataset to the Collaborative Cross mouse dataset of adult mouse morphology already found on FaceBase.
DOI: 10.25550/1wwy
title: Kesselman. FaceBase 2 Coordinating Center

description: The collection, sharing and integration of heterogeneous data, including genetic, imaging, and anatomical, from human and animal models are essential for advancing craniofacial research. We will develop and maintain a FaceBase 2 Data Management and Integration Hub infrastructure that will properly store, represent, and serve these data to the research community, and in addition provide access to tools for visualizing, integrating, annotating, linking and analyzing the data. Our three broad aims will provide not only the needed data migration and management, but also a set of user-centered tools for data visualization, comparison and annotation. ### Aims **Aim 1** Create an infrastructure driven by principles of ease of use and user centered design to manage data throughout its lifecycle. By taking a user centric approach and supporting the use of data throughout its lifecycle, the rate of discovery and utility of the hub can be maximized. **Aim 2** Provide tools within the Hub that accelerate craniofacial research by enabling data annotation, integration and analysis. To maximize the utility of the Hub for both spoke projects and outside users, our proposed infrastructure will allow any user to define a personal workspace, organize datasets visualization tools and analysis tools into specific user- driven workflows. **Aim 3** Promote use and collaboration across the FaceBase research network. The Hub will provide a wide range of collaboration tools and services to the consortium as well as organizing face-to-face meetings in order to enhance collaboration. We have assembled an experienced team of experts in bioinformatics, imaging, genetics, mouse and human studies, including FaceBase participants who bring firsthand knowledge of the needs within the craniofacial research community. The FaceBase team is intentionally diverse, to provide each spoke group at least one informed contact who will play an integral role in the development and implementation of the Hub, thereby ensuring that the data of each spoke project will have maximum impact on the community of researchers.
DOI: 10.25550/1wx2
title: Brinkley. The Ontology of Craniofacial Development and Malformation

description: The purpose of the national FaceBase consortium is to systemically acquire and integrate multiple forms of data in order to facilitate a systems level understanding of the causes and possible treatments for craniofacial abnormalities. A basic component of any such data integration effort is a controlled set of terms or keywords that can be associated with the data through data annotation, so that diverse data can be related via common terms. If in addition, the terms are related to each other in an ontology, then integration can occur at the level of meaning rather than simply via keywords. As part of FaceBase1, we designed and partially implemented the Ontology of Craniofacial Development and Malformation (OCDM), based on our Foundational Model of Anatomy ontology (FMA). The OCDM currently consists of components for representing human and mouse adult and developmental anatomy and malformations, as well as mappings between homologous structures in the two organisms. ### Aims **Aim 1** Since the focus of FaceBase1 was cleft lip and palate, the initial focus of the ontology was representation of structures and developmental relations relevant to these conditions in mouse and human. In FaceBase2, we will greatly extend the Ontology of Craniofacial Development and Malformation (OCDM) from FaceBase 1 to accommodate conditions of interest to FaceBase2 researchers, such as human and mouse facial, palatal, and cranial vault development, and dysmorphology such as craniosynostosis, midface hypoplasia, frontonasal dysplasia, craniofacial microsomia and microtia. These malformations will require extensive structural and developmental representation of the entire musculoskeletal system of the head, as well as associated soft tissue anatomy that includes the integumentary system, deep fascial system, viscerocranial mucosa, adipose tissue, eyes, ears, tongue, vasculature and neural network. **Aim 2** Incorporate and add relations to the Zfin ontology to reflect the inclusion of zebrafish in FaceBase 2. **Aim 3** Release versions of the OCDM to the FaceBase Hub in OWL 2. By conforming to ontology best practices such as OWL 2, the OCDM will be interoperable with other efforts that are contributing to the overall world-wide semantic web of linked data and knowledge.
DOI: 10.25550/1wvt
title: Chai. Research on Functional Genomics, Image Analysis and Rescue of Cleft Palate

description: The development of the FaceBase Consortium calls for a comprehensive research collaboration to facilitate data collection, organization, and optimized utilization of new and existing data on mid-facial development and malformations. Our laboratory has a long history of investigating the molecular and cellular mechanism of cleft palate. We have developed a proposal that builds on our strength and will focus on genomic and imaging analysis of selected and highly clinically relevant cleft palate animal models. Specifically, we will use the Tgfb, Tgfbr, Smad4, Msx1 and Fgfr2 mutant animal models that represent complete and sub-mucous cleft palate defects in humans as our entry point. Taking advantage of these animal models, we will work closely with several scientists to address the regulatory mechanism of CNC cell fate determination. Specifically, working with Dr. Marianne Bronner-Fraser at California Institute of Technology (Caltech), we will investigate whether the neural crest gene regulatory network of traditional vertebrate models is conserved and may exert its regulatory function during palatogenesis. In collaboration with Dr. Joseph Hacia at USC, we will discover critical components of the Tgf-b signaling network that are specifically involved in regulating the fate of CNC cells during palatogenesis. Working with Dr. Scott Fraser at Caltech, we will generate comprehensive and dynamic three-dimensional images of palatogenesis and malformations using microMRI and microCT. Finally, we have developed a strategy to screen for specific points of intervention within the gene regulatory network that will allow us to develop therapeutic strategies to prevent and rescue cleft palate. Our collective effort will not only generate tremendous resources for the FaceBase Consortium but will also offer opportunities for extensive collaborations for future translational research on craniofacial birth defects.
DOI: 10.25550/1wwa
title: Maas. Rapid Identification and Validation of Human Craniofacial Development Genes

description: The advent of new genomic sequencing technologies has made the task of gene discovery in human developmental disorders highly efficient. Simultaneously, advances in gene targeting in model organisms, specifically in zebrafish, have made semi-high throughput validation and analysis of human candidate genes feasible, including those responsible for craniofacial disorders. This project will take advantage of this convergence of new technologies to identify and functionally validate approximately two dozen genes involved in novel aspects of human craniofacial development. Specifically, we will take advantage of already ascertained collections of craniofacial dysmorphoses from Boston Children’s Hospital (BCH) and from King Faisal Specialist Hospital and Research Center (KFSHRC) in Saudi Arabia, where the high incidence of consanguinity makes autozygosity mapping and the identification of recessive causal loci highly feasible. We will extend the work of FaceBase beyond its current focus on disorders of palatal development by including a relatively wide range of craniofacial disorders that involve other components of the craniofacial complex. In addition, use of resources already compiled by FaceBase, including detailed gene expression data in mouse and zebrafish, enhancer analyses, and genome wide association studies, in combination with the present data and publicly available datasets, will further facilitate the functional annotation of these newly validated genes.
DOI: 10.25550/1wwm
title: Fraser. Functional Analysis of Neural Crest and Palate

description: The research plan will refine and deploy a set of advanced tools for the imaging of tissue structure, gene expression domains and cellular dynamics during craniofacial development. Volumetric imaging tools will be used to create accurate 3D atlases that can be digitally dissected to permit the tissue interactions and cellular events to be better understood in the forming faces of normal, mutant and perturbed mouse and avian embryos. Molecular imaging agents, optimized for imaging intact tissues, will be employed to create atlases of the molecular correlates of these embryos. Finally, intravital imaging tools will be used to study cell and tissue interactions as they take place, offering a view into the dynamic events that execute craniofacial development. The data will be assembled into atlases that will offer unprecedented tools for exploring the cellular, tissue and molecular correlates of craniofacial development. These atlases will be made widely available for the use of others in the Face Base consortium and the broader community of craniofacial researchers through an online resource created locally. In addition, they will be linked to other Face Base resources through established hubs, so that the data in our atlases can be used in concert with the molecular and structural data provided by other members of the consortium. The data acquisition pipeline established here in close collaboration with the laboratories of Dr. Yang Chai (University of Southern California) and Dr. Marianne Bronner-Fraser (Caltech) will create a model that can be expanded to phenotype and analyze other experimental systems.
DOI: 10.6084/m9.figshare.11862861.v12
title: Simulated zero-crossing wave period (3-hourly, 150a) from FIO-ESM v2.0 abrupt-4xCO2 experiment r1i1p1f1

description: Simulated zero-crossing wave period (3-hourly, 150a) from FIO-ESM v2.0 abrupt-4xCO2 experiment (CO2 abruptly quadrupled and then held constant) r1i1p1f1, which is branch from Jan 1, 301 of piControl experiment. The grid, named gx1v6, is the displaced pole (the North Pole displaced to the Greenland) grid with 1.1 degree in longitude and 0.27-0.54 degree in latitude.
DOI: 10.34619/qexq-m560
title: Metabolic and Transcriptional Response to Cofactor Perturbations in Escherichia coli [Datasets]

description: Data from the manuscript: Holm AK, Blank LM, Oldiges M, et al. Metabolic and transcriptional response to cofactor perturbations in Escherichia coli. J Biol Chem. 2010;285(23):17498-17506. doi:10.1074/jbc.M109.095570
DOI: 10.5519/qd.03azjjs4
title: Query on the Natural History Museum Data Portal (data.nhm.ac.uk) (744340 records)
DOI: 10.7910/dvn/uqzmon/aikie9
title: DIM_PUBLICATIONS_INFO.tab

description: :unav
DOI: 10.7910/dvn/uqzmon/s3napz
title: DIM_PHASES.tab

description: :unav
DOI: 10.7910/dvn/uqzmon/ev3s7w
title: FACT_PUBLICATIONS.tab

description: :unav
DOI: 10.7910/dvn/uqzmon/mlfzgb
title: DIM_CRPS.tab

description: :unav
DOI: 10.7910/dvn/uqzmon/m6qksu
title: DIM_EXT_PARTNERS.tab

description: :unav
DOI: 10.6084/m9.figshare.11862861.v13
title: Simulated zero-crossing wave period (3-hourly, 150a) from FIO-ESM v2.0 abrupt-4xCO2 experiment r1i1p1f1

description: Simulated zero-crossing wave period (3-hourly, 150a) from FIO-ESM v2.0 abrupt-4xCO2 experiment (CO2 abruptly quadrupled and then held constant) r1i1p1f1, which is branch from Jan 1, 301 of piControl experiment. The grid, named gx1v6, is the displaced pole (the North Pole displaced to the Greenland) grid with 1.1 degree in longitude and 0.27-0.54 degree in latitude.
DOI: 10.34619/8qdf-kk03
title: Metabolic and Transcriptional Response to Cofactor Perturbations in Escherichia coli [Datasets]

description: Data from the manuscript: Holm AK, Blank LM, Oldiges M, et al. Metabolic and transcriptional response to cofactor perturbations in Escherichia coli. J Biol Chem. 2010;285(23):17498-17506. doi:10.1074/jbc.M109.095570
DOI: 10.25919/5e4e057d6bced
title: Parkes observations for project PX500 semester 2019OCTS_08

description: This proposal relates to time purchased by the Chinese Academy of Sciences for Parkes follow-up confirmation and timing of FAST discoveries. As the observing time has been purchased this proposal (and the related PX501) does not require TAC grading. The primary reason for submitting a proposal is to ensure an outreach statement and that the proposal is entered into OPAL for the data archive to access. The Chinese team have two time requests. The time scheduled for the first, relating to this proposal, will be allocated in blocks of 24 hours and the data will become available in the data archive with an 18 month embargo period. The second type of time will be scheduled in shorter blocks and the data archived with a 10 year embargo.
DOI: 10.25919/5e4e042605e93
title: Parkes observations for project P958 semester 2019OCTS_52

description: Fast radio bursts (FRBs) continue to raise more questions than they answer. Until last year, only one burst – the only one known to repeat - had been localized to a bright radio nebula (either a young supernova remnant or pulsar wind nebulae) in a distant dwarf galaxy. Over the last two year searches with the Australian Square Kilometre Array Pathfinder (ASKAP) have detected 31 bursts, five of which have been localised to host galaxies at redshifts ranging from 0.1 to 0.5. These bursts and their hosts are very unlike the repeater, suggesting there may be a dichotomy in the population. However one of the arcminute-localised ASKAP FRBs has recently been found to repeat. Here we propose to search and study repetitions in this FRB population. Our comprehensive sample and a dense monitoring campaign of well localised bursts, at a fluence limit more than 60 times lower than that of their detections to characterise the fraction of bursts that repeat. For bursts that repeat the unique wide bandwidth observations will be used to test leading models of burst emission.
DOI: 10.5281/zenodo.3674512
title: Tables of the paper"A Conceptual Model of Chinese Oral Memory Based on Digital Humanities"

description: Those are the tables used for the paper "A Conceptual Model of Chinese Oral Memory Based on Digital Humanities".
DOI: 10.5281/zenodo.3674513
title: Tables of the paper"A Conceptual Model of Chinese Oral Memory Based on Digital Humanities"

description: Those are the tables used for the paper "A Conceptual Model of Chinese Oral Memory Based on Digital Humanities".
DOI: 10.18141/1599565
title: Newberry Volcano magnetotelluric impedance data

description: This submission includes all magnetotelluric (MT) transfer functions acquired during the 2014 EGS stimulation at Newberry Volcano in central Oregon as well as previously acquired MT data for the overall volcano. Plots of all data are provided (including forward response from a model used in a publication now in review in G-cubed). Also included is a kmz file giving all station locations.
DOI: 10.17632/5ykfj2cg6x.1
title: Data for: Activity profile, mass distribution index, radiants, and orbits of the 2018 Draconid meteor shower outburst.

description: Geocentric radiants and heliocentric orbit of 2018 Draconid meteors
DOI: 10.14457/sdu.res.2019.3
title: การพัฒนารูปแบบเครือข่ายความร่วมมือเพื่อเพิ่มคุณภาพการจัดการศึกษา ระดับปฐมวัยของศูนย์พัฒนาเด็กเล็ก สังกัดองค์กรปกครองส่วนท้องถิ่น: การวิจัยเชิงปฏิบัติการแบบมีส่วนร่วม
DOI: 10.14457/sdu.res.2019.4
title: การพัฒนารูปแบบการสื่อสารการตลาดออนไลน์สินค้าเกษตรอินทรีย์ของวิสาหกิจชุมชน
DOI: 10.14457/sdu.res.2019.5
title: การจัดกิจกรรมการเรียนรู้แบบบูรณาการผสานกับภูมิปัญญาท้องถิ่น เพื่อพัฒนาความคิดสร้างสรรค์ของเด็กปฐมวัยกลุ่มชาติพันธุ์ลาวครั่ง อำเภอด่านช้าง จังหวัดสุพรรณบุรี
DOI: 10.14457/sdu.res.2018.80
title: การหาสภาวะที่เหมาะสมในการสกัดและการทดสอบฤทธิ์ยับยั้งเอนไซม์ไทโรซิเนสของเปลือกหุ้มเมล็ดมะขามเปรี้ยวยักษ์
DOI: 10.14457/sdu.res.2019.6
title: ความเครียดในการปฏิบัติงานของอาจารย์ผู้รับผิดชอบหลักสูตร ตามเกณฑ์มาตรฐานหลักสูตรระดับอุดมศึกษา
DOI: 10.14457/sdu.res.2019.7
title: การพัฒนาการตลาดท่องเที่ยวของผู้สูงอายุเพื่อส่งเสริมอุตสาหกรรม การท่องเที่ยวในประเทศไทย
DOI: 10.14457/sdu.res.2019.8
title: การผลิตซอสพริกแบบผงกึ่งสำเร็จรูปโดยวิธีการทำแห้งแบบโฟมแมท
DOI: 10.14457/sdu.res.2019.9
title: การท่องเที่ยวเชิงวัฒนธรรมไทยเพื่อพัฒนาสุขภาพผู้สูงอายุ ตำบลหนองแก อำเภอหัวหิน จังหวัดประจวบคีรีขันธ์
DOI: 10.14457/sdu.res.2019.10
title: ดิ โนอิ้ง เกม ยกระดับการเรียนรู้สู่ห้องเรียน
DOI: 10.14457/sdu.res.2019.11
title: มรดกภูมิปัญญาทางวัฒนธรรมของไทย กับการพัฒนาระบบพาณิชย์อิเล็กทรอนิกส์ตามหลักเศรษฐกิจสร้างสรรค์
DOI: 10.5519/qd.7lh3svwu
title: Query on the Natural History Museum Data Portal (data.nhm.ac.uk) (2350932 records)
DOI: 10.5519/qd.usljrjkz
title: Query on the Natural History Museum Data Portal (data.nhm.ac.uk) (1246084 records)