cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.26180/22192846
title: DIC Images and surface view photographs for 'The development of fault networks at the termination of continental transform faults when their connecting plate boundary is ‘misaligned’"

description: Supplementary material for the manuscript: <br> "The development of fault networks at the termination of continental transform faults when their connecting plate boundary is ‘misaligned’"
DOI: 10.26180/22192846.v3
title: DIC Images and surface view photographs for 'The development of fault networks at the termination of continental transform faults when their connecting plate boundary is ‘misaligned’"

description: Supplementary material for the manuscript: <br> "The development of fault networks at the termination of continental transform faults when their connecting plate boundary is ‘misaligned’"
DOI: 10.26180/22192846.v2
title: DIC Images and surface view photographs for 'The development of fault networks at the termination of continental transform faults when their connecting plate boundary is ‘misaligned’"

description: Supplementary material for the manuscript: <br> "The development of fault networks at the termination of continental transform faults when their connecting plate boundary is ‘misaligned’"
DOI: 10.5281/zenodo.8173953
title: Okręgi parafialne diecezji przemyskiej w 1600 roku

description: Okręgi parafialne łacińskiej diecezji przemyskiej na 1600 rok wobec braku źródła przekrojowego zostały zrekonstruowane na podstawie dokumentów fundacyjnych i erekcyjnych parafii, wykazów świadczeń kmiecych oraz materiału wizytacyjnego. Szczególnie przydatne były nieodległe w czasie protokoły wizytacji ks. Fryderyka Alembeka z lat 1636-1642 (niestety niekompletne) oraz późniejsze. Sporadycznie sięgano po materiał z XVIII stulecia, zwłaszcza akta lustracji biskupa Wacława H. Sierakowskiego z lat 1743-1745 i 1753-1757. Dokumentację dla poszczególnych parafii zawiera praca G. Klebowicz, Organizacja parafialna diecezji przemyskiej obrządku łacińskiego w XIV-XVI w., Lublin 2013, s. 149-379.<br> Struktura dekanalna odzwierciedla podział przeprowadzony na synodzie diecezjalnym w 1594 roku. Ponieważ spis parafii w dekanatach nie zachował się w komplecie, brakujące fragmenty zostały uzupełnione i zrekonstruowane na podstawie późniejszych źródeł, zob. G. Klebowicz, Organizacja…, s. 138-145.
DOI: 10.5281/zenodo.8173952
title: Okręgi parafialne diecezji przemyskiej w 1600 roku

description: Okręgi parafialne łacińskiej diecezji przemyskiej na 1600 rok wobec braku źródła przekrojowego zostały zrekonstruowane na podstawie dokumentów fundacyjnych i erekcyjnych parafii, wykazów świadczeń kmiecych oraz materiału wizytacyjnego. Szczególnie przydatne były nieodległe w czasie protokoły wizytacji ks. Fryderyka Alembeka z lat 1636-1642 (niestety niekompletne) oraz późniejsze. Sporadycznie sięgano po materiał z XVIII stulecia, zwłaszcza akta lustracji biskupa Wacława H. Sierakowskiego z lat 1743-1745 i 1753-1757. Dokumentację dla poszczególnych parafii zawiera praca G. Klebowicz, Organizacja parafialna diecezji przemyskiej obrządku łacińskiego w XIV-XVI w., Lublin 2013, s. 149-379.<br> Struktura dekanalna odzwierciedla podział przeprowadzony na synodzie diecezjalnym w 1594 roku. Ponieważ spis parafii w dekanatach nie zachował się w komplecie, brakujące fragmenty zostały uzupełnione i zrekonstruowane na podstawie późniejszych źródeł, zob. G. Klebowicz, Organizacja…, s. 138-145.
DOI: 10.6084/m9.figshare.23731332
title: Data with legends.xls

description: Data set of 821 patients to assess the sleep quality in the urban slum
DOI: 10.34740/kaggle/dsv/6176084
title: AutoXGB
DOI: 10.34740/kaggle/dsv/6176073
title: LUFlow Network Intrusion Detection Data Set
DOI: 10.5281/zenodo.8174001
title: Dataset: GLS variation by ultrasound frequency change

description: This is the dataset containing the global longitudinal strain (GLS) values measured by 3 different ultrasound frequency presets. This was used to investigate the influence of ultrasound frequency on GLS measurement by 2D-speckle tracking echocardiography.
DOI: 10.5281/zenodo.8174000
title: Dataset: GLS variation by ultrasound frequency change

description: This is the dataset containing the global longitudinal strain (GLS) values measured by 3 different ultrasound frequency presets. This was used to investigate the influence of ultrasound frequency on GLS measurement by 2D-speckle tracking echocardiography.
DOI: 10.3886/icpsr08690
title: New York Times Survey, December 1985
title: Archival Version

description: The major political parties are the focus of this survey. Respondents were asked to evaluate whether the Democratic or Republican party would do a better job of handling inflation, unemployment, foreign trade problems, the federal budget deficit, and new problems that may arise in the future, and whether either party would be more likely to keep the United States out of war and keep defenses strong. Respondents also were asked to identify which party has more money, is more organized, and cares more about the needs of big business, women, labor unions, farmers, and blacks. In addition, respondents were asked who they considered to be the important leaders of each party and if there were any groups within each party that concerned them. Other items include the respondent's party identification and voting history, Ronald Reagan's performance as President, big corporations, government corruption, the United States Supreme Court, and abortion. Demographic characteristics also are included.
description: The data are not weighted, however there is one weight variable, V7 (WEIGHT), that users may wish to apply during analysis.
description: Stratified random digit dialing.
description: Datasets: DS1: New York Times Survey, December 1985
description: Eligible voters 18 years or older. Smallest Geographic Unit: state
description: telephone interviewThis dataset has a weight variable that must be used in all analyses.
DOI: 10.6084/m9.figshare.21550707
title: Supplementary Material for: Protocol-dependent morphological changes in human embryonic stem cell aggregates during differentiation towards early pancreatic fate

description: Cell therapy is one of the promising approaches used against type1 diabetes. Efficient generation of Human embryonic stem cell (hESC)-derived pancreatic progenitors (PPs) is of great importance. Since signaling pathways underlying human pancreas development is not yet fully understood, various differentiation protocols are conducted each considering variable duration, timing and concentrations of growth factors and small molecules. Therefore, we compared two PP differentiation protocols in static suspension culture. We tested modified protocols developed by Pagliuca et al. (protocol-1) and Royan researchers (protocol-2) until early PP stage. The morphological changes of hESC aggregates during differentiation, and also gene and protein expression after differentiation were evaluated. Different morphological structures were formed in each protocol. Quantitative gene expression analysis, flow cytometry and immunostaining revealed a high level of PDX1 expression on day 13 of Royan’s differentiation protocol compared to protocol-1. Our data showed that using protocol-2, cells were further differentiated until day16 showing higher efficiency of early PPs. Moreover, protocol-2 is able to produce hESCs-PPs in a static suspension culture. Since protocol-2 is inexpensive in terms of media, growth factors and chemicals, it can be used for massive production of PPs using static and dynamic suspension cultures.
DOI: 10.6084/m9.figshare.21815376
title: Supplementary Material for: Adalimumab for the Treatment of Periodontitis in a 35-Year-Old Woman with Hidradenitis Suppurativa

description: Increasing evidence suggests an association between chronic inflammatory conditions and oral health. Herein, we present a case of a 35-year-old woman with concomitant hidradenitis suppurativa (HS) and periodontitis, who was treated successfully with adalimumab. After 3 months of treatment, a marked improvement was observed in her clinical scores of HS, quality of life, as well as her gingival pain and signs of inflammation. This finding calls for a closer collaboration between dermatologists and dentists to further explore the possible beneficial role of biologic therapy for chronic inflammatory skin conditions as well as periodontitis.
DOI: 10.6084/m9.figshare.21976178
title: Supplementary Material for: Medulloblastoma development in a patient with a constitutional balanced t(5;22)(q35.1;q11.2) involving the NF2 gene.

description: Neurofibromatosis type 2 (NF2) is a brain tumor predisposing syndrome caused by inactivating alterations of the NF2 gene mapped at chromosome 22q. Currently, no genetic information exists on medulloblastomas occurring in NF2 patients. We herein report on the genetic alterations observed in a girl in which the NF2 gene was de novo altered due to a constitutional translocation: t(5;22)(q35.1;q11.2). This girl had a particularly aggressive disease course. At the age of 4 she had already been diagnosed with, three lesions classified as schwannomas, and a meningioma. At 10-years-old she developed a medulloblastoma. She died at the age of 14 due to a refractory acute myeloid leukemia (AML). From the genetic point of view, we observed that: 1) the NF2 gene was rearranged in all patient samples: blood, tumor, and leukemic cells; 2) loss of 3’ region of NF2 and the downstream regions of chromosome 22 were only detected in medulloblastoma cells; 3) the known cancer AML related gene: NPM1 which is mapped at 5q35.1 was not the target of any alteration in our patient. Our data suggests that inactivation of the NF2 gene was relevant for the medulloblastoma pathogenesis. Furthermore, we know that malignant cancers are the result of a multi-epi-genetic sequence of events, and although, unquestionably limited to the genetic findings in one case. We may hypothesize, that as described for a fraction of medulloblastomas, the alteration of a gene mapped at 5q might also have been relevant for medulloblastoma development in our patient.
DOI: 10.6084/m9.figshare.21981170
title: Supplementary Material for: Possible Efficacy of Vedolizumab, an Anti-α4β7 Integrin Antibody, in Palmoplantar Pustulosis

description: Palmoplantar pustulosis (PPP) is a chronic skin inflammatory disease in which blisters and pustules repeatedly develop on palms and soles. PPP is often refractory to topical therapy, oral therapy, phototherapy, and biologics that are usually applied for PPP. We report a patient with PPP improved by vedolizumab (anti-α4β7 integrin antibody) treatment for ulcerative colitis, suggesting the possibility of a new molecular target for PPP therapy.
DOI: 10.6084/m9.figshare.21988712
title: Supplementary Material for: Synergistic Toxicities from Multiple Therapies for Synchronous Malignancies

description: Patients may present with multiple malignancies in the setting of particular environmental and occupational exposures. These patients often require combination systemic therapy not yet studied for concurrent use. While toxicities for specific chemotherapies and immunotherapies may be well known, the possibility of exaggerated toxicity due to combination therapy exists and is understudied. Several trials are under way that may shed further light on how combination therapies affect patient toxicity. This case report outlines the unfortunate development of severe edema and rash, refractory to traditional methods of management, from combining immunotherapy and chemotherapy.
DOI: 10.6084/m9.figshare.22047311
title: Supplementary Material for: Soluble ST2 Predicts Poor Functional Outcome in Acute Ischemic Stroke Patients

description: Introduction: There is very limited data on the role of biomarkers correlating with the outcome in acute ischemic stroke (AIS). We evaluated the predictive values of the plasma concentrations of soluble Serum Stimulation-2 (sST2), Matrix Metalloproteinase-9 (MMP-9), and Claudin-5 in AIS. Methods: The biomarker levels in the plasma samples of consecutive AIS patients collected at baseline, 12 hours, and 24 hours from stroke onset, were quantified using immunoassays. Stroke severity was assessed using the National Institutes of Health Stroke Scale (NIHSS) and functional outcome at 90 days using the modified Rankin Scale (mRS), with scores of 3-6 defined as poor outcome. Receiver operating characteristic curve analysis and multiple logistic regression was conducted for evaluating the discriminative power of each marker. Results: We included 108 patients in the study (mean age 62.3±11.7 years). Median NIHSS score was 12 [IQR 8-18]. High baseline glucose levels, systolic blood pressure, baseline NIHSS, low ASPECTS (Alberta Stroke Program Early CT Score), and hemorrhagic transformation were associated with poor outcomes. Elevated sST2 at 12 hours (50.4±51.0 ng/mL; P=0.047) and 24 hours (81.8±101.3 ng/mL; P=0.001) positively correlated with poor outcomes. MMP-9 (P=0.086) and Claudin-5 (P=0.2) were not significantly associated with the outcome although increased expressions of both markers were observed at 12 hours. Multiple logistic regression showed that sST2 levels ≥71.8 ng/mL at 24 hours, with a specificity of 96.9%, emerged as an independent predictor of poor functional outcome (OR: 6.44,95% CI:1.40-46.3; P=0.029). Conclusion: Evaluation of soluble ST2 may act as a reliable biomarker of functional outcome in AIS.
DOI: 10.6084/m9.figshare.22093595
title: Supplementary Material for: A case of bilateral synchronous paratesticular leiomyoma

description: Bilateral synchronous paratesticular leiomyoma (BSPL) is a rare tumor that originates from smooth muscle cells in the paratesticular region. Four BSPL cases have been reported sporadically, starting with the 1991 report by Aus and Boiesen. Herein, we report the case of a 60-year-old male with a bilateral scrotal mass with a maximum size of 7.5 cm. Histological examination revealed oval to spindle-shaped tumor cells with a fascicular growth pattern. Immunohistochemically, the tumor cells were positive for α-smooth muscle actin. The pathological diagnosis was a leiomyoma. Based on the simultaneous bilateral nature of the disease, BSPL was diagnosed. In conclusion, we encountered a rare case of BSPL, and our report may contribute to the understanding of this disease.
DOI: 10.6084/m9.figshare.22188997
title: Supplementary Material for: Eosinophilic Fasciitis Presenting as an Ichthyosiform Eruption of the Bilateral Ankles

description: Eosinophilic fasciitis (EF) is a rare connective tissue disease which closely resembles other scleroderma-like diseases. EF presents with painful swelling and hardening of the distal limbs and is often preceded by a history of strenuous exercise. The marked fascial fibrosis in EF can lead to joint contractures and causes significant morbidity in affected individuals. The authors present a rare case of EF presenting as an ichthyosiform eruption of the bilateral ankles with gradual improvement after the implementation of oral prednisone, hydroxychloroquine, and methotrexate.
DOI: 10.6084/m9.figshare.22284343
title: Supplementary Material for: Case Report of AdAPT-001-Mediated Sensitization to a Previously Failed Checkpoint Inhibitor in a Metastatic Chordoma Patient

description: Chordoma is a rare, but aggressive bone tumor with a high recurrence rate that primarily arises at the cranial and caudal ends of the axial skeleton. Systemic chemotherapies are not effective against the tumor, and outside of surgical resection and radiation, no approved options are available. Prognosis depends on the extent of surgical resection, with the more the better, and adjuvant radiotherapy. Herein is presented the first ever case of a recurrent chordoma patient that responded to the combination of one dose of an experimental TGF-beta (TGFβ) trap carrying oncolytic adenovirus, known as AdAPT-001, followed by immune checkpoint inhibitor therapy, despite prior progression on an anti-PD-1. This case report highlights the potential of AdAPT-001 as a treatment modality in combination with checkpoint inhibition for recurrent chordoma.
DOI: 10.6084/m9.figshare.22284379
title: Supplementary Material for: Zanubrutinib in the maintenance treatment of elderly people with primary central nervous system lymphoma (PCNSL): a report of two cases

description: Primary central nervous system lymphoma (PCNSL) is a rare and aggressive extranodal non-Hodgkin lymphoma. The predominant subtype is diffuse large B-cell lymphoma (DLBCL), and no systematic lesion is identified at diagnosis. BTKi (Bruton's tyrosine kinase inhibitor) has demonstrated significant clinical activity in DLBCL. We retrospectively reported two patients who began with memory deterioration or right limb movement disabilities. A cranial magnetic resonance imaging (MRI) scan and a brain biopsy were used to diagnose PCNSLs. For induction treatment, middle-dose methotrexate (HD-MTX) regimens were initiated. Due to the patients' inability to tolerate continuous MTX regimens due to severe infections, zanubrutinib was chosen as the maintenance regimen instead. For one patient, the drug was well-tolerated, he achieved sustained complete remission (CR) as demonstrated by MRI, and he survived 14 months after diagnosis. Another patient achieved partial remission (PR) and continued to live six months after diagnosis. As an intriguing possibility, we successfully extended the PFS and OS in elderly PCNSL patients treated with zanubrutinib.
DOI: 10.6084/m9.figshare.22304329
title: Supplementary Material for: Sotorasib as first-line treatment for Advanced KRAS G12C-mutated Non-small cell lung cancer-A case report.

description: Mutations in the KRAS gene are the most common gain-of-function mutations found in lung adenocarcinomas. The most common mutation, KRAS G12C, is present in 13% of lung adenocarcinomas. Sotorasib (AMG-510) is an irreversible small molecule inhibitor targeting KRAS G12C. In preclinical studies, sotorasib treatment led to regression of KRAS G12C-mutated tumors and clinical efficacy in NSCLC was demonstrated in clinical trials. In May 2021, sotorasib received FDA approval for the treatment of locally advanced or metastatic KRAS G12C-mutated NSCLC who have received at least one prior systemic therapy. In this report, we present a case with metastatic, KRAS G12C mutated NSCLC who responded favorably to sotorasib as first-line therapy. The efficacy of sotorasib as first-line treatment in this patient was remarkable, which supports further study of sotorasib as first-line therapy for KRAS G12C-mutated NSCLC, especially fragile patients with comorbidities.
DOI: 10.6084/m9.figshare.22324978
title: Supplementary Material for: Circulating tumor DNA testing overcomes limitations of comprehensive genomic profiling from tumor tissue

description: The “liquid biopsy” is an established technique for examining circulating tumor DNA (ctDNA) from a routine blood draw and detecting actionable biomarkers. Nonetheless, ctDNA testing is rarely utilized for patients with newly diagnosed metastatic colorectal cancer (CRC). We report a case in which ctDNA testing uncovered an actionable biomarker that was not detected by comprehensive genomic profiling of tumor tissue. An 81-year-old woman with a remote history of non-Hodgkin’s lymphoma presented with primary masses in the ascending colon and sigmoid colon. The ascending colon and sigmoid colon tumors were classified as microsatellite stable (MSS) and mismatch repair proficient (pMMR), and both ctDNA and tissue next-generation sequencing (NGS) from the ascending colon mass were ordered. Because tissue NGS results indicated that the ascending colon tumor was MSS, palliative 5-fluorouracil, leucovorin, and oxaliplatin (FOLFOX) chemotherapy was started. However, the ctDNA NGS results that arrived after the start of FOLFOX found high microsatellite instability (MSI-H) and mismatch repair deficient (dMMR) disease with a serine/threonine-protein kinase B-Raf (BRAFV600E) mutation. To treat both her MSS/pMMR ascending colon and sigmoid colon tumors and MSI-H/dMMR metastatic disease, the immunotherapy nivolumab was added to FOLFOX. After 8 months of combined nivolumab and chemotherapy, the patient’s metastatic disease had a complete clinical response. This case highlights the complementary role of ctDNA testing for biomarker identification. By performing simultaneous ctDNA testing at the time of diagnosis, an actionable biomarker was discovered that significantly altered this patient’s prognosis and treatment options. Orthogonal testing of key molecular alterations offers significant advantages for identifying actionable biomarkers and improving management of metastatic CRC.
DOI: 10.6084/m9.figshare.22360516
title: Supplementary Material for: Mistaken Metastasis: Radiation-Induced Rib Fracture Mimicking Malignancy on CT Case Report

description: A 62-year-old woman with a 40-pack-year smoking history and severe chronic obstructive pulmonary disease (COPD) with early-stage right upper lobe non-small cell lung cancer (NSCLC) was treated with stereotactic ablative radiotherapy (SABR). Two years after treatment, a surveillance computerized tomography (CT) scan showed lesions of the posterior 4th and 5th ribs including expansion of the medulla that was unusual and of concern for possible malignant infiltration. A follow-up magnetic resonance (MRI) scan revealed these lesions to be healing fractures post-radiotherapy. Although generally well-tolerated, SABR is known to produce inflammatory and fibrotic changes both in-field and in organs at risk, and rib fractures are a well-established adverse event. Magnetic resonance imaging has high diagnostic accuracy and sensitivity for rib fractures and was able to rule out malignant spread. This case demonstrates the need for regular follow-up following stereotactic ablative radiotherapy for early-stage NSCLC, as well as the challenge of interpreting indeterminate post-stereotactic ablative radiotherapy radiography findings.
DOI: 10.6084/m9.figshare.22691554
title: Supplementary Material for: Brain Structural Correlates of Obstacle Negotiation in Mild Cognitive Impairment: Results from The Gait and Brain Study

description: Introduction- Mild Cognitive Impairment (MCI) affects obstacle negotiation capabilities, potentially increasing the risk of falls in older adults. However, it is unclear whether smaller brain volumes typically observed in older individuals with MCI are related to the observed hazardous obstacle negotiation in this population. Methods- A total of 93 participants (71.9±5.36years of age; MCI=53 / Control=40) from the Gait and Brain Study were analyzed. Gray matter (GM) volumes from the frontal, temporal and parietal lobes were entered in the analysis. Gait performance was recorded using a 6-m electronic walkway during two cognitive load conditions while approaching and stepping over an obstacle: 1) single-task; 2) while counting backwards by 1s from 100 (dual-task). Anticipatory adjustments in gait performance to cross an “ad hoc” obstacle were electronically measured during pre-crossing phases: early(3 steps before the late phase) and late(3 steps before obstacle). Association between the percentage of change in average gait speed and step length from early to late (i.e. anticipatory adjustments) and GM volumes were investigated using multivariate models adjusted for potential confounders. Results- Anticipatory adjustments in gait speed (Wilks’ lambda .35; eta2 .64; p=.01) and step length (Wilks’ lambda .33; eta2 .66; p=.01) during dual-task condition were globally associated with GM volumes in MCI. Individuals with MCI with smaller GM volumes in the left inferior frontal gyrus, left hippocampus, right hippocampus and right entorhinal cortex made significantly fewer anticipatory gait adjustments prior to crossing the obstacle. Discussion/Conclusion- Frontotemporal atrophy may affect obstacle negotiation capabilities potentially increasing the risk of falls in MCI.