cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.25549/hhrohp-ouc112194229
title: Ruth Morgan Thomas, interview, North Middleton, Scotland, UK, 2022

description: Ruth Morgan Thomas, North Middleton, Scotland, United Kingdom, 2022 June 24, oral history inteview, by Maylis Basturk, Los Angeles, California, USA. The inteview was conducted over the Internet (Zoom) as part of the Health and Human Rights Oral History Project.Ruth Morgan Thomas has fought for the health, rights and dignity of sex workers for more than thirty years: eight years as a sex worker, two and a half years as an academic researcher at Edinburgh University looking at HIV-related risks in the sex industry, and twenty-plus years as a sex workers’ rights advocate within UK, European, and global contexts. She is the outgoing Global Coordinator of the Network of Sex Work Projects (NSWP), and currently co-chairs the UNAIDS Advisory Group on HIV and Sex Work on behalf of the NSWP. In her oral history, she shares the trajectory of her career as an advocate for sex workers, from her first engagement with sex workers' rights, through confrontations with sex-work abolionists and decades of work and learnings as a leading human rights defender.
DOI: 10.6084/m9.figshare.19608940
title: Hox transcript antisense RNA knockdown inhibits osteosarcoma progression by regulating the phosphoinositide 3-kinase/AKT pathway through the microRNA miR-6888-3p/spleen tyrosine kinase axis

description: Long non-coding RNA HOX transcript antisense RNA (lncRNA HOTAIR) is thought to be a key regulator of the occurrence and development of osteosarcoma (OS). The expression of HOTAIR, microRNA miR-6888-3p, spleen tyrosine kinase (SYK), and phosphoinositide 3-kinase/AKT (PI3K/AKT) pathway-related proteins in OS was detected by quantitative reverse transcription-PCR (qRT-PCR) and western blotting. Changes in the proliferation and migration of OS cells were detected by Cell Counting Kit-8 (CCK-8) and transwell assays after the knockdown of HOTAIR, miR-6888-3p, or SYK. Luciferase assays, RNA immunoprecipitation (RIP), and RNA pull-down assays were used to detect the relationship between miR-6888-3p and HOTAIR or SYK. We found that HOTAIR and SYK were highly expressed in OS, whereas miR-6888-3p expression was low. In addition, downregulation of HOTAIR or SYK significantly inhibited the growth and migration of OS cells and the PI3K/AKT pathway, both <i>in vitro</i> and <i>in vivo</i>. Additionally, downregulation of miR-6888-3p promoted the proliferation and migration of OS cells and activated the PI3K/AKT pathway. Mechanistically, these results suggest that the HOTAIR sponge, miR-6888-3p, regulates SYK expression. To summarize, HOTAIR regulates SYK by acting on miR-6888-3p, thereby promoting the proliferation and migration of OS cells.
DOI: 10.25549/hhrohp-ouc112194228
title: Ruth Morgan Thomas, interview, North Middleton, Scotland, UK, 2022

description: Ruth Morgan Thomas, North Middleton, Scotland, United Kingdom, 2022 June 24, oral history inteview, by Maylis Basturk, Los Angeles, California, USA. The inteview was conducted over the Internet (Zoom) as part of the Health and Human Rights Oral History Project.Ruth Morgan Thomas has fought for the health, rights and dignity of sex workers for more than thirty years: eight years as a sex worker, two and a half years as an academic researcher at Edinburgh University looking at HIV-related risks in the sex industry, and twenty-plus years as a sex workers’ rights advocate within UK, European, and global contexts. She is the outgoing Global Coordinator of the Network of Sex Work Projects (NSWP), and currently co-chairs the UNAIDS Advisory Group on HIV and Sex Work on behalf of the NSWP. In her oral history, she shares the trajectory of her career as an advocate for sex workers, from her first engagement with sex workers' rights, through confrontations with sex-work abolionists and decades of work and learnings as a leading human rights defender.
DOI: 10.25549/hhrohp-ouc112194227
title: Ruth Morgan Thomas, interview, North Middleton, Scotland, UK, 2022

description: Ruth Morgan Thomas, North Middleton, Scotland, United Kingdom, 2022 June 24, oral history inteview, by Maylis Basturk, Los Angeles, California, USA. The inteview was conducted over the Internet (Zoom) as part of the Health and Human Rights Oral History Project.Ruth Morgan Thomas has fought for the health, rights and dignity of sex workers for more than thirty years: eight years as a sex worker, two and a half years as an academic researcher at Edinburgh University looking at HIV-related risks in the sex industry, and twenty-plus years as a sex workers’ rights advocate within UK, European, and global contexts. She is the outgoing Global Coordinator of the Network of Sex Work Projects (NSWP), and currently co-chairs the UNAIDS Advisory Group on HIV and Sex Work on behalf of the NSWP. In her oral history, she shares the trajectory of her career as an advocate for sex workers, from her first engagement with sex workers' rights, through confrontations with sex-work abolionists and decades of work and learnings as a leading human rights defender.
DOI: 10.5281/zenodo.10647633
title: Data synthesis of preferred thermotolerances in elasmobranchs

description: A datasynthesis based on existing knowledge summarising preferred thermotolerances in elasmobranchs
DOI: 10.5281/zenodo.10647634
title: Data synthesis of preferred thermotolerances in elasmobranchs

description: A datasynthesis based on existing knowledge summarising preferred thermotolerances in elasmobranchs
DOI: 10.25549/hhrohp-ouc112194225
title: Ruth Morgan Thomas, interview, North Middleton, Scotland, UK, 2022

description: Ruth Morgan Thomas, North Middleton, Scotland, United Kingdom, 2022 June 24, oral history inteview, by Maylis Basturk, Los Angeles, California, USA. The inteview was conducted over the Internet (Zoom) as part of the Health and Human Rights Oral History Project.Ruth Morgan Thomas has fought for the health, rights and dignity of sex workers for more than thirty years: eight years as a sex worker, two and a half years as an academic researcher at Edinburgh University looking at HIV-related risks in the sex industry, and twenty-plus years as a sex workers’ rights advocate within UK, European, and global contexts. She is the outgoing Global Coordinator of the Network of Sex Work Projects (NSWP), and currently co-chairs the UNAIDS Advisory Group on HIV and Sex Work on behalf of the NSWP. In her oral history, she shares the trajectory of her career as an advocate for sex workers, from her first engagement with sex workers' rights, through confrontations with sex-work abolionists and decades of work and learnings as a leading human rights defender.
DOI: 10.25549/hhrohp-ouc112194226
title: Ruth Morgan Thomas, interview, North Middleton, Scotland, UK, 2022

description: Ruth Morgan Thomas, North Middleton, Scotland, United Kingdom, 2022 June 24, oral history inteview, by Maylis Basturk, Los Angeles, California, USA. The inteview was conducted over the Internet (Zoom) as part of the Health and Human Rights Oral History Project.Ruth Morgan Thomas has fought for the health, rights and dignity of sex workers for more than thirty years: eight years as a sex worker, two and a half years as an academic researcher at Edinburgh University looking at HIV-related risks in the sex industry, and twenty-plus years as a sex workers’ rights advocate within UK, European, and global contexts. She is the outgoing Global Coordinator of the Network of Sex Work Projects (NSWP), and currently co-chairs the UNAIDS Advisory Group on HIV and Sex Work on behalf of the NSWP. In her oral history, she shares the trajectory of her career as an advocate for sex workers, from her first engagement with sex workers' rights, through confrontations with sex-work abolionists and decades of work and learnings as a leading human rights defender.
DOI: 10.6084/m9.figshare.7026065
title: Interfering histone deacetylase 4 inhibits the proliferation of vascular smooth muscle cells via regulating MEG3/miR-125a-5p/IRF1

description: In this study, we investigated the role ofhistone deacetylase 4 (HDAC4) and MEG3/miR-125a-5p/interferonregulatoryfactor 1 (IRF1) on vascular smooth muscle cell (VSMCs)proliferation. Platelet derived growth factor (PDGF)-BB was used toinduce the proliferation and migration of VSMCs. The expressionsof MEG3, miR-125a-5p, HDAC4 and IRF1in VSMCs were detectedby qRT-PCR and western blot, respectively. ChIP assay was usedto determine the relationship between MEG3 and HDAC4. Doubleluciferase reporter assay was used to test the regulation betweenmiR-125-5p and IRF1. Results showed that PDGF-BB decreasedthe expression of MEG3 and IRF1, while increased the expressionof miR-125a-5p and HDAC4. In addition, HDAC4 knockdowninhibited the proliferation and migration of VSMCs via upregulatingMEG3 and downregulating miR-125a-5p. MiR-125a-5p inhibitorcould repress the proliferation and migration of VSMCs andalleviate intimal hyperplasia (IH) by directly upregulating IRF1expression. These results suggested that HDAC4 interferenceinhibited PDGF-BB-induced VSMCs proliferation via regulatingMEG3/miR-125a-5p/IRF1 axis, and then alleviated IH.
DOI: 10.25549/hhrohp-ouc112194224
title: Raluca Bunea, interview, Berlin, Germany, 2022

description: Raluca Bunea, Berlin, Germany, 2022 April 28, oral history interview, by Asna Tabassum, Los Angeles, California, USA. The inteview was conducted over the Internet (Zoom) as part of the Health and Human Rights Oral History Project, Institute on Inequalities in Global Health, University of Southern California, Los Angeles, California, USA.This oral history covers Raluca Bunea’s years as a program officer and then director of the Open Society Foundations’ global work on mental health and rights within the Public Health Program (PHP), during which she also helped to oversee portfolios of work on race, ethnicity, and health equity. During her tenure with the PHP, Bunea developed programming to support the systemic shift from institutional to community-based care in Europe and Eurasia and co-led advocacy to repurpose European Funds for institutional reforms in this area. She also led the establishment of a new body of work at the Foundations focused on the social and political determinants of mental health, and the influence of the pharmaceutical industry in mental health policy in the development space. In her interview, she recounts how she entered into the disability rights space in Eastern Europe in the early 2000’s, and how the PHP played a significant role in mental health policy and financing. She describes the interplay of philanthropy with community-based organizations, NGOs, and the pharmaceutical industry to mobilize advocacy around the social and political determinants of mental health globally.
DOI: 10.6084/m9.figshare.13317580
title: A new symmetrical nickel(II) complex with isothiocyanate coordination: synthesis, crystal structure, Hirshfeld surface analysis, DFT calculation and antibacterial activities

description: The metal salts KSCN, Ni(CH<sub>3</sub>COO)<sub>2</sub>·4H<sub>2</sub>O, and auxiliary ligand pyridine were added respectively to the salamo-like ligand H<sub>2</sub>L, and it is expected that the Ni(II) complex coordinated by H<sub>2</sub>L will be obtained. X-ray analysis of the obtained blue bulk single crystal revealed that the ligand H<sub>2</sub>L did not participate in the coordination, and a mononuclear Ni(II) complex [Ni(Py)<sub>4</sub>(NCS)<sub>2</sub>] contained four coordinated pyridine molecules was unexpectedly obtained, and characterized by IR, UV-Visible spectroscopy, and X-ray diffraction. The Ni(II) atom was surrounded by six N atoms, formed a slightly distorted octahedral geometry configuration. Hirshfeld surfaces analyses were performed to determine the various interactions presented in the molecule. DFT calculations were also conducted. In antimicrobial tests, the Ni(II) complex exhibited better inhibition of <i>Escherichia coli</i> relative to <i>Staphylococcus aureus</i>.
DOI: 10.6084/m9.figshare.13317580.v1
title: A new symmetrical nickel(II) complex with isothiocyanate coordination: synthesis, crystal structure, Hirshfeld surface analysis, DFT calculation and antibacterial activities

description: The metal salts KSCN, Ni(CH<sub>3</sub>COO)<sub>2</sub>·4H<sub>2</sub>O, and auxiliary ligand pyridine were added respectively to the salamo-like ligand H<sub>2</sub>L, and it is expected that the Ni(II) complex coordinated by H<sub>2</sub>L will be obtained. X-ray analysis of the obtained blue bulk single crystal revealed that the ligand H<sub>2</sub>L did not participate in the coordination, and a mononuclear Ni(II) complex [Ni(Py)<sub>4</sub>(NCS)<sub>2</sub>] contained four coordinated pyridine molecules was unexpectedly obtained, and characterized by IR, UV-Visible spectroscopy, and X-ray diffraction. The Ni(II) atom was surrounded by six N atoms, formed a slightly distorted octahedral geometry configuration. Hirshfeld surfaces analyses were performed to determine the various interactions presented in the molecule. DFT calculations were also conducted. In antimicrobial tests, the Ni(II) complex exhibited better inhibition of <i>Escherichia coli</i> relative to <i>Staphylococcus aureus</i>.
DOI: 10.25549/hhrohp-ouc112194223
title: Raluca Bunea, interview, Berlin, Germany, 2022

description: Raluca Bunea, Berlin, Germany, 2022 April 28, oral history interview, by Asna Tabassum, Los Angeles, California, USA. The inteview was conducted over the Internet (Zoom) as part of the Health and Human Rights Oral History Project, Institute on Inequalities in Global Health, University of Southern California, Los Angeles, California, USA.This oral history covers Raluca Bunea’s years as a program officer and then director of the Open Society Foundations’ global work on mental health and rights within the Public Health Program (PHP), during which she also helped to oversee portfolios of work on race, ethnicity, and health equity. During her tenure with the PHP, Bunea developed programming to support the systemic shift from institutional to community-based care in Europe and Eurasia and co-led advocacy to repurpose European Funds for institutional reforms in this area. She also led the establishment of a new body of work at the Foundations focused on the social and political determinants of mental health, and the influence of the pharmaceutical industry in mental health policy in the development space. In her interview, she recounts how she entered into the disability rights space in Eastern Europe in the early 2000’s, and how the PHP played a significant role in mental health policy and financing. She describes the interplay of philanthropy with community-based organizations, NGOs, and the pharmaceutical industry to mobilize advocacy around the social and political determinants of mental health globally.
DOI: 10.25549/hhrohp-ouc112194221
title: Raluca Bunea, interview, Berlin, Germany, 2022

description: Raluca Bunea, Berlin, Germany, 2022 April 28, oral history interview, by Asna Tabassum, Los Angeles, California, USA. The inteview was conducted over the Internet (Zoom) as part of the Health and Human Rights Oral History Project, Institute on Inequalities in Global Health, University of Southern California, Los Angeles, California, USA.This oral history covers Raluca Bunea’s years as a program officer and then director of the Open Society Foundations’ global work on mental health and rights within the Public Health Program (PHP), during which she also helped to oversee portfolios of work on race, ethnicity, and health equity. During her tenure with the PHP, Bunea developed programming to support the systemic shift from institutional to community-based care in Europe and Eurasia and co-led advocacy to repurpose European Funds for institutional reforms in this area. She also led the establishment of a new body of work at the Foundations focused on the social and political determinants of mental health, and the influence of the pharmaceutical industry in mental health policy in the development space. In her interview, she recounts how she entered into the disability rights space in Eastern Europe in the early 2000’s, and how the PHP played a significant role in mental health policy and financing. She describes the interplay of philanthropy with community-based organizations, NGOs, and the pharmaceutical industry to mobilize advocacy around the social and political determinants of mental health globally.
DOI: 10.6084/m9.figshare.7026065.v1
title: Interfering histone deacetylase 4 inhibits the proliferation of vascular smooth muscle cells via regulating MEG3/miR-125a-5p/IRF1

description: In this study, we investigated the role ofhistone deacetylase 4 (HDAC4) and MEG3/miR-125a-5p/interferonregulatoryfactor 1 (IRF1) on vascular smooth muscle cell (VSMCs)proliferation. Platelet derived growth factor (PDGF)-BB was used toinduce the proliferation and migration of VSMCs. The expressionsof MEG3, miR-125a-5p, HDAC4 and IRF1in VSMCs were detectedby qRT-PCR and western blot, respectively. ChIP assay was usedto determine the relationship between MEG3 and HDAC4. Doubleluciferase reporter assay was used to test the regulation betweenmiR-125-5p and IRF1. Results showed that PDGF-BB decreasedthe expression of MEG3 and IRF1, while increased the expressionof miR-125a-5p and HDAC4. In addition, HDAC4 knockdowninhibited the proliferation and migration of VSMCs via upregulatingMEG3 and downregulating miR-125a-5p. MiR-125a-5p inhibitorcould repress the proliferation and migration of VSMCs andalleviate intimal hyperplasia (IH) by directly upregulating IRF1expression. These results suggested that HDAC4 interferenceinhibited PDGF-BB-induced VSMCs proliferation via regulatingMEG3/miR-125a-5p/IRF1 axis, and then alleviated IH.
DOI: 10.6084/m9.figshare.25213787
title: Dataset identifying the posts and comments used in our

description: Dataset identifies the number of posts per day during our data collection efforts and the posts/comments included in our analysis
DOI: 10.6084/m9.figshare.25213787.v1
title: Dataset identifying the posts and comments used in our

description: Dataset identifies the number of posts per day during our data collection efforts and the posts/comments included in our analysis
DOI: 10.25549/hhrohp-ouc112194222
title: Raluca Bunea, interview, Berlin, Germany, 2022

description: Raluca Bunea, Berlin, Germany, 2022 April 28, oral history interview, by Asna Tabassum, Los Angeles, California, USA. The inteview was conducted over the Internet (Zoom) as part of the Health and Human Rights Oral History Project, Institute on Inequalities in Global Health, University of Southern California, Los Angeles, California, USA.This oral history covers Raluca Bunea’s years as a program officer and then director of the Open Society Foundations’ global work on mental health and rights within the Public Health Program (PHP), during which she also helped to oversee portfolios of work on race, ethnicity, and health equity. During her tenure with the PHP, Bunea developed programming to support the systemic shift from institutional to community-based care in Europe and Eurasia and co-led advocacy to repurpose European Funds for institutional reforms in this area. She also led the establishment of a new body of work at the Foundations focused on the social and political determinants of mental health, and the influence of the pharmaceutical industry in mental health policy in the development space. In her interview, she recounts how she entered into the disability rights space in Eastern Europe in the early 2000’s, and how the PHP played a significant role in mental health policy and financing. She describes the interplay of philanthropy with community-based organizations, NGOs, and the pharmaceutical industry to mobilize advocacy around the social and political determinants of mental health globally.
DOI: 10.6084/m9.figshare.7026512
title: Neonatal respiratory outcomes in pregnancy induced hypertension: introducing a novel index

description: <b>Objective:</b> To evaluate short-term respiratory outcomes, mortality and bronchopulmonary dysplasia (BPD) in preterm infants born to mothers with and without pregnancy induced hypertension (PIH). <b>Methods:</b> Exposed infants &lt;33 weeks’ gestation were matched to controls in a 1:2 ratio, based on gestation, sex and antenatal steroid exposure in this retrospective cohort study. Primary outcomes were a novel cumulative respiratory index (cRI) (product of mean airway pressure-hours and FiO<sub>2</sub>-hours while on invasive ventilation during first 72 hours), mortality and BPD. <b>Results:</b> Seventy-nine exposed infants were matched with 158 controls. cRI was higher in exposed infants (median 1854; IQR 186–13,901) versus controls (median 1359; IQR 210–11,302) but not statistically significant (<i>p</i> = .63). On conditional regression analysis, PIH did not predict cRI (adjusted <i>β</i> = 0.96; 95% CI = 0.79–1.17; <i>p</i> = .712). No association between PIH and mortality (unadjusted odds ratio [OR] = 3.14; 95% CI = 0.76–13.0; <i>p</i>=.11) was identified. PIH was significantly associated with BPD on univariate analysis (OR = 2.29; 95% CI = 1.02–5.17; <i>p</i>=.046), but not after adjustment (aOR = 1.26; 95% CI = 0.38–4.19; <i>p</i>=.7). <b>Conclusions:</b> PIH was not associated with cRI, mortality or BPD in this study. Further validation of cRI and exploration of its relationship with PIH as well as neonatal outcomes is warranted.
DOI: 10.25549/hhrohp-ouc112194141
title: Nina Schwalbe, interview, New York, NY, USA, 2022

description: Nina Schwalbe, New York, New York, USA, 2022 June 9, oral history interview, by Asna Tabassum, Los Angeles, California, USA. The inteview was conducted over the Internet (Zoom) as part of the Health and Human Rights Oral History Project, Institute on Inequalities in Global Health, University of Southern California, Los Angeles, California, USA.Nina Schwalbe has held numerous leadership positions in public health including recently establishing USAID's COVID-19 Vaccine Access and Delivery Initiative and serving as its first director. She was Managing Director for Policy and Performance at Gavi, the vaccine alliance, and served as the principal advisor and acting chief of health at Unicef, overseeing their health programs in over 150 countries. Schwalbe's oral history centers on the early years of her career working for the Open Society Foundations' Moscow Office and going on to direct its Public Health Program, showing how her early work in Russia provided a blueprint for decades of subsequent health and human rights work within the foundations. This included Schwalbe’s leadership in combating MDR tuberculosis in Russian prisons, which laid the groundwork for the global fight against TB.
DOI: 10.25549/hhrohp-ouc112194140
title: Nina Schwalbe, interview, New York, NY, USA, 2022

description: Nina Schwalbe, New York, New York, USA, 2022 June 9, oral history interview, by Asna Tabassum, Los Angeles, California, USA. The inteview was conducted over the Internet (Zoom) as part of the Health and Human Rights Oral History Project, Institute on Inequalities in Global Health, University of Southern California, Los Angeles, California, USA.Nina Schwalbe has held numerous leadership positions in public health including recently establishing USAID's COVID-19 Vaccine Access and Delivery Initiative and serving as its first director. She was Managing Director for Policy and Performance at Gavi, the vaccine alliance, and served as the principal advisor and acting chief of health at Unicef, overseeing their health programs in over 150 countries. Schwalbe's oral history centers on the early years of her career working for the Open Society Foundations' Moscow Office and going on to direct its Public Health Program, showing how her early work in Russia provided a blueprint for decades of subsequent health and human rights work within the foundations. This included Schwalbe’s leadership in combating MDR tuberculosis in Russian prisons, which laid the groundwork for the global fight against TB.