cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.9767513.v1
title: Supplementary Material for: Direct Oral Anticoagulant Plasma Levels for the Management of Acute Ischemic Stroke

description: <b><i>Introduction:</i></b> The management of acute ischemic stroke in patients on direct oral anticoagulants (DOACs) is challenging. However, the substance-specific plasma level could guide treatment decisions on recanalization therapies. We present a plasma-level-based protocol for emergency treatment of stroke patients on oral anticoagulants. Bleeding complications and clinical outcome for patients on DOACs are reported and compared to patients on vitamin K antagonists (VKAs). <b><i>Methods:</i></b> In patients with acute ischemic stroke and suspected use of DOACs within 48 h prior to hospital admission, plasma levels were measured using the calibrated Xa-activity (apixaban, edoxaban, rivaroxaban) or the Hemoclot®-assay (dabigatran). Levels &lt;50 ng/mL were supportive for thrombolysis, while high values &gt;100 ng/mL excluded patients from recombinant tissue plasminogen activator use. For patients on VKAs, the cutoff was set at international normalized ratio of 1.7. Endovascular thrombectomy of a large vessel occlusion was performed independently from coagulation testing. Consecutive patients were included in an observational registry. <b><i>Results:</i></b> Five hundred and twenty-two patients (261 on VKAs and 261 on DOACs) were included. Thirty patients (11.5%) on VKAs and 24 (9.2%) on DOACs received thrombolysis, followed by mechanical thrombectomy in 10 and 14 patients, respectively. Seventeen patients in each group received thrombectomy only. Symptomatic intracranial hemorrhage associated with thrombolysis occurred in 1 patient on VKA (3.3%) and 1 on DOAC (4.2%; <i>p</i> = 0.872). The turnaround time of specific assays did not show a significant delay in comparison to standard coagulation parameters. <b><i>Conclusion:</i></b> DOAC plasma levels could support decisions on emergency treatment of ischemic stroke. Systemic thrombolysis below suggested thresholds appears preliminary feasible and safe without an excess in bleeding complications.
DOI: 10.6084/m9.figshare.9767423
title: Wagg_Nat_Comm_2019_Data

description: See the word document "Data_description.doc" for a detailed description of each .csv data file.
DOI: 10.6084/m9.figshare.9767564.v1
title: Borup Fiord Pass - Metagenome Assembled Genomes (MAGs)

description: These are the Metagenome Assembled Genomes generated and presented for a publication in preparation to AEM.<br><br>These data were generated from samples collected at Borup Fiord Pass between 2014 and 2017.
DOI: 10.6084/m9.figshare.9767732.v3
title: Five Minute Dungeon Timer Data

description: Data from playing Five Minute Dungeon Timer in two classes at YorkU.<br>Rep is the replicate of playing the game.Date is calendar date.Boss is the monster to defeat.Outcome is won or lost defined as whether completed and beat the boss is less than 5 minutes using the timer app associated with the game.Time is in seconds and is the moment a given team called out that they beat that particular boss.Joy is how much fun it was to play based on that instance. These measure is a Likert Scale from 1 to 5 with 1 being not fun at all and 5 being awesome.<br><br>
DOI: 10.6084/m9.figshare.9767732.v4
title: Five Minute Dungeon Timer Data

description: Data from playing Five Minute Dungeon Timer in two classes at YorkU.<br>Rep is the replicate of playing the game.Date is calendar date.Boss is the monster to defeat.Outcome is won or lost defined as whether completed and beat the boss is less than 5 minutes using the timer app associated with the game.Time is in seconds and is the moment a given team called out that they beat that particular boss.Joy is how much fun it was to play based on that instance. These measure is a Likert Scale from 1 to 5 with 1 being not fun at all and 5 being awesome.<br><br>
DOI: 10.6084/m9.figshare.9767732.v5
title: Five Minute Dungeon Timer Data

description: Data from playing Five Minute Dungeon Timer in two classes at YorkU.<br>Rep is the replicate of playing the game.Date is calendar date.Boss is the monster to defeat.Outcome is won or lost defined as whether completed and beat the boss is less than 5 minutes using the timer app associated with the game.Time is in seconds and is the moment a given team called out that they beat that particular boss.Joy is how much fun it was to play based on that instance. These measure is a Likert Scale from 1 to 5 with 1 being not fun at all and 5 being awesome.<br><br>
DOI: 10.6084/m9.figshare.9767732.v6
title: Five Minute Dungeon Timer Data

description: Data from playing Five Minute Dungeon in two classes at YorkU.<br>MetadataRep is the replicate of playing the game.Date is calendar date.Boss is the monster to defeat.Outcome is won or lost defined as whether completed and beat the boss in less than 5 minutes using the timer app associated with the game.Time is in seconds and is the moment a given team called out that they beat that particular boss.Joy is how much fun it was to play based on that instance. These measure is a Likert Scale from 1 to 5 with 1 being not fun at all and 5 being awesome.<br><br>
DOI: 10.6084/m9.figshare.9767732.v7
title: Five Minute Dungeon Timer Data

description: Data from playing Five Minute Dungeon in two classes at YorkU.<br>MetadataRep is the replicate of playing the game.Date is calendar date.Boss is the monster to defeat.Outcome is won or lost defined as whether completed and beat the boss in less than 5 minutes using the timer app associated with the game.Time is in seconds and is the moment a given team called out that they beat that particular boss.Joy is how much fun it was to play based on that instance. These measure is a Likert Scale from 1 to 5 with 1 being not fun at all and 5 being awesome.<br><br>
DOI: 10.6084/m9.figshare.9767732.v8
title: Five Minute Dungeon Timer Data

description: Data from playing Five Minute Dungeon in two classes at YorkU.<br>MetadataRep is the replicate of playing the game.Date is calendar date.Boss is the monster to defeat.Outcome is won or lost defined as whether completed and beat the boss in less than 5 minutes using the timer app associated with the game.Time is in seconds and is the moment a given team called out that they beat that particular boss.Joy is how much fun it was to play based on that instance. These measure is a Likert Scale from 1 to 5 with 1 being not fun at all and 5 being awesome.<br><br>
DOI: 10.6084/m9.figshare.9767732.v9
title: Five Minute Dungeon Timer Data

description: Data from playing Five Minute Dungeon in two classes at YorkU.<br>MetadataRep is the replicate of playing the game.Date is calendar date.Boss is the monster to defeat.Outcome is won or lost defined as whether completed and beat the boss in less than 5 minutes using the timer app associated with the game.Time is in seconds and is the moment a given team called out that they beat that particular boss.Joy is how much fun it was to play based on that instance. These measure is a Likert Scale from 1 to 5 with 1 being not fun at all and 5 being awesome.<br><br>
DOI: 10.6084/m9.figshare.9767732.v10
title: Five Minute Dungeon Timer Data

description: Data from playing Five Minute Dungeon in two classes at YorkU.<br>MetadataRep is the replicate of playing the game.Date is calendar date.Boss is the monster to defeat.Outcome is won or lost defined as whether completed and beat the boss in less than 5 minutes using the timer app associated with the game.Time is in seconds and is the moment a given team called out that they beat that particular boss.Joy is how much fun it was to play based on that instance. These measure is a Likert Scale from 1 to 5 with 1 being not fun at all and 5 being awesome.<br><br>
DOI: 10.6084/m9.figshare.9767732.v11
title: Five Minute Dungeon Timer Data

description: Data from playing Five Minute Dungeon in two classes at YorkU.<br>MetadataRep is the replicate of playing the game.Date is calendar date.Boss is the monster to defeat.Outcome is won or lost defined as whether completed and beat the boss in less than 5 minutes using the timer app associated with the game.Time is in seconds and is the moment a given team called out that they beat that particular boss.Joy is how much fun it was to play based on that instance. These measure is a Likert Scale from 1 to 5 with 1 being not fun at all and 5 being awesome.<br><br>
DOI: 10.6084/m9.figshare.9767273
title: Supplementary Material for: Molecular Basis of ABO Variants Including Identification of 16 Novel <b><i>ABO</i></b> Subgroup Alleles in Chinese Han Population

description: <b><i>Introduction:</i></b> The characteristic of ABO blood subgroup is crucial for elucidating the mechanisms of such variant phenotypes and offering useful information in blood transfusion. <b><i>Methods:</i></b> In total, 211 ABO variants including part of available family members were investigated in this study. The phenotypes of these individuals were typed with serologic methods. The full coding regions of <i>ABO</i> gene and the erythroid cell-specific regulatory elements in intron 1 of them were amplified with polymerase chain reaction and then directly sequenced. The novel alleles were confirmed by cloning and sequencing. Phylogenetic tree was made using CLUSTAL W software. 3D structural analyses of the glycosyltransferases (GTs) with some typical mutations were performed by PyMOL software. <b><i>Results:</i></b> Forty-eight distinctly rare <i>ABO</i> alleles were identified in 211 Chinese variant individuals, including 16 novel <i>ABO</i> alleles. All of the alleles were categorized as 5 groups: 16 <i>ABO</i>*<i>A</i> alleles, 23<i> ABO</i>*<i>B</i> alleles, 4 <i>ABO</i>*<i>BA</i> alleles, 4 <i>ABO</i>*<i>cisAB</i> alleles, and 1 <i>ABO</i>*<i>O</i> alleles. <i>ABO</i>*<i>A2.08</i> and <i>ABO</i>*<i>BA.02</i> were the relatively predominant <i>A</i> and <i>B</i> subgroup alleles, respectively. According to the phylogenetic tree, 28 alleles (5 common alleles and 23 alleles identified in our laboratory) were classified into 3 major allelic lineages. The structural analysis of 3D homology modeling predicted reduced protein stability of the mutant GTs and may explain the reduced ABO antigen expression. <b><i>Conclusions:</i></b> The molecular basis of ABO variants was analyzed, and 16 novel <i>ABO</i> alleles were identified. The results extended the information of ABO variants and provided a basis for better transfusion strategies and helped to improve blood transfusion safety.
DOI: 10.6084/m9.figshare.9767267
title: Supplementary data-BNs.xlsx

description: Node probability tables for the Bayesian networks models of different SSM approaches.
DOI: 10.6084/m9.figshare.9767267.v1
title: Supplementary data-BNs.xlsx

description: Node probability tables for the Bayesian networks models of different SSM approaches.
DOI: 10.6084/m9.figshare.9767273.v1
title: Supplementary Material for: Molecular Basis of ABO Variants Including Identification of 16 Novel <b><i>ABO</i></b> Subgroup Alleles in Chinese Han Population

description: <b><i>Introduction:</i></b> The characteristic of ABO blood subgroup is crucial for elucidating the mechanisms of such variant phenotypes and offering useful information in blood transfusion. <b><i>Methods:</i></b> In total, 211 ABO variants including part of available family members were investigated in this study. The phenotypes of these individuals were typed with serologic methods. The full coding regions of <i>ABO</i> gene and the erythroid cell-specific regulatory elements in intron 1 of them were amplified with polymerase chain reaction and then directly sequenced. The novel alleles were confirmed by cloning and sequencing. Phylogenetic tree was made using CLUSTAL W software. 3D structural analyses of the glycosyltransferases (GTs) with some typical mutations were performed by PyMOL software. <b><i>Results:</i></b> Forty-eight distinctly rare <i>ABO</i> alleles were identified in 211 Chinese variant individuals, including 16 novel <i>ABO</i> alleles. All of the alleles were categorized as 5 groups: 16 <i>ABO</i>*<i>A</i> alleles, 23<i> ABO</i>*<i>B</i> alleles, 4 <i>ABO</i>*<i>BA</i> alleles, 4 <i>ABO</i>*<i>cisAB</i> alleles, and 1 <i>ABO</i>*<i>O</i> alleles. <i>ABO</i>*<i>A2.08</i> and <i>ABO</i>*<i>BA.02</i> were the relatively predominant <i>A</i> and <i>B</i> subgroup alleles, respectively. According to the phylogenetic tree, 28 alleles (5 common alleles and 23 alleles identified in our laboratory) were classified into 3 major allelic lineages. The structural analysis of 3D homology modeling predicted reduced protein stability of the mutant GTs and may explain the reduced ABO antigen expression. <b><i>Conclusions:</i></b> The molecular basis of ABO variants was analyzed, and 16 novel <i>ABO</i> alleles were identified. The results extended the information of ABO variants and provided a basis for better transfusion strategies and helped to improve blood transfusion safety.
DOI: 10.6084/m9.figshare.9767732.v12
title: Five Minute Dungeon Timer Data

description: Data from playing Five Minute Dungeon in two classes at YorkU.<br>MetadataRep is the replicate of playing the game.Date is calendar date.Boss is the monster to defeat.Outcome is won or lost defined as whether completed and beat the boss in less than 5 minutes using the timer app associated with the game.Time is in seconds and is the moment a given team called out that they beat that particular boss.Joy is how much fun it was to play based on that instance. These measure is a Likert Scale from 1 to 5 with 1 being not fun at all and 5 being awesome.<br><br>
DOI: 10.6084/m9.figshare.9767231
title: The importance of time limits in detecting signs of left visual peripersonal neglect: a multiple single-case, pilot study

description: We developed a new visual search test to assess signs of left visual peripersonal neglect. Five right-hemisphere-damaged patients, 10 healthy controls, and 10 orthopedic controls were administered the test in four conditions: easy task (no distractors)/time-limited (45’’), easy task (no distractors)/time-unlimited, difficult task (distractors)/time-limited (45’’), difficult task (distractors)/time-unlimited. With respect to controls, most RHDP showed signs of left visual peripersonal neglect in the time-limited condition, but not in the time-unlimited condition, particularly on the difficult task. We suggest that the presence of appropriate time limits, in difficult visual search tasks, could considerably improve the diagnosis of left visual peripersonal neglect.
DOI: 10.6084/m9.figshare.9767732.v14
title: Five Minute Dungeon Timer Data

description: Data from playing Five Minute Dungeon in two classes at YorkU.<br>MetadataRep is the replicate of playing the game.Date is calendar date.Boss is the monster to defeat.Outcome is won or lost defined as whether completed and beat the boss in less than 5 minutes using the timer app associated with the game.Time is in seconds and is the moment a given team called out that they beat that particular boss.Joy is how much fun it was to play based on that instance. These measure is a Likert Scale from 1 to 5 with 1 being not fun at all and 5 being awesome.<br><br>
DOI: 10.6084/m9.figshare.9767222
title: Supplementary R Code from Host genetic diversity limits parasite success beyond agricultural systems: a meta-analysis

description: There is evidence that human activities are reducing the population genetic diversity of species worldwide. Given the prediction that parasites better exploit genetically homogeneous host populations, many species could be vulnerable to disease outbreaks. While agricultural studies have shown the devastating effects of infectious disease in crop monocultures, the widespread nature of this diversity–disease relationship remains unclear in natural systems. Here, we provide broad support that high population genetic diversity can protect against infectious disease by conducting a meta-analysis of 23 studies, with a total of 67 effect sizes. We found that parasite functional group (micro- or macroparasite) affects the presence of the effect and study setting (field or laboratory-based environment) influences the magnitude. Our study also suggests that host genetic diversity is overall a robust defence against infection regardless of host reproduction, parasite's host range, parasite diversity, virulence and the method by which parasite success was recorded. Combined, these results highlight the importance of monitoring declines of host population genetic diversity as shifts in parasite distributions could have devastating effects on at-risk populations in nature.
DOI: 10.6084/m9.figshare.9767219
title: Dataset from Host genetic diversity limits parasite success beyond agricultural systems: a meta-analysis

description: There is evidence that human activities are reducing the population genetic diversity of species worldwide. Given the prediction that parasites better exploit genetically homogeneous host populations, many species could be vulnerable to disease outbreaks. While agricultural studies have shown the devastating effects of infectious disease in crop monocultures, the widespread nature of this diversity–disease relationship remains unclear in natural systems. Here, we provide broad support that high population genetic diversity can protect against infectious disease by conducting a meta-analysis of 23 studies, with a total of 67 effect sizes. We found that parasite functional group (micro- or macroparasite) affects the presence of the effect and study setting (field or laboratory-based environment) influences the magnitude. Our study also suggests that host genetic diversity is overall a robust defence against infection regardless of host reproduction, parasite's host range, parasite diversity, virulence and the method by which parasite success was recorded. Combined, these results highlight the importance of monitoring declines of host population genetic diversity as shifts in parasite distributions could have devastating effects on at-risk populations in nature.
DOI: 10.6084/m9.figshare.9767222.v1
title: Supplementary R Code from Host genetic diversity limits parasite success beyond agricultural systems: a meta-analysis

description: There is evidence that human activities are reducing the population genetic diversity of species worldwide. Given the prediction that parasites better exploit genetically homogeneous host populations, many species could be vulnerable to disease outbreaks. While agricultural studies have shown the devastating effects of infectious disease in crop monocultures, the widespread nature of this diversity–disease relationship remains unclear in natural systems. Here, we provide broad support that high population genetic diversity can protect against infectious disease by conducting a meta-analysis of 23 studies, with a total of 67 effect sizes. We found that parasite functional group (micro- or macroparasite) affects the presence of the effect and study setting (field or laboratory-based environment) influences the magnitude. Our study also suggests that host genetic diversity is overall a robust defence against infection regardless of host reproduction, parasite's host range, parasite diversity, virulence and the method by which parasite success was recorded. Combined, these results highlight the importance of monitoring declines of host population genetic diversity as shifts in parasite distributions could have devastating effects on at-risk populations in nature.
DOI: 10.6084/m9.figshare.9767231.v1
title: The importance of time limits in detecting signs of left visual peripersonal neglect: a multiple single-case, pilot study

description: We developed a new visual search test to assess signs of left visual peripersonal neglect. Five right-hemisphere-damaged patients, 10 healthy controls, and 10 orthopedic controls were administered the test in four conditions: easy task (no distractors)/time-limited (45’’), easy task (no distractors)/time-unlimited, difficult task (distractors)/time-limited (45’’), difficult task (distractors)/time-unlimited. With respect to controls, most RHDP showed signs of left visual peripersonal neglect in the time-limited condition, but not in the time-unlimited condition, particularly on the difficult task. We suggest that the presence of appropriate time limits, in difficult visual search tasks, could considerably improve the diagnosis of left visual peripersonal neglect.
DOI: 10.6084/m9.figshare.9767732.v13
title: Five Minute Dungeon Timer Data

description: Data from playing Five Minute Dungeon in two classes at YorkU.<br>MetadataRep is the replicate of playing the game.Date is calendar date.Boss is the monster to defeat.Outcome is won or lost defined as whether completed and beat the boss in less than 5 minutes using the timer app associated with the game.Time is in seconds and is the moment a given team called out that they beat that particular boss.Joy is how much fun it was to play based on that instance. These measure is a Likert Scale from 1 to 5 with 1 being not fun at all and 5 being awesome.<br><br>
DOI: 10.6084/m9.figshare.9767216
title: Cranial osteology and systematics of the enigmatic early ‘sail-backed’ synapsid <i>Echinerpeton intermedium</i> Reisz, 1972, and a review of the earliest ‘pelycosaurs’

description: The early synapsid <i>Echinerpeton intermedium</i> from Florence, Nova Scotia, was first described as a basal ophiacodontid ‘pelycosaur’, displaying the oldest record of hyper-elongated neural spines in an amniote. Since its initial discovery, the systematic placement of <i>Echinerpeton intermedium</i> has been less clear than that of its contemporary <i>Archaeothyris florensis.</i> The difficulty in assigning the remains of <i>Echinerpeton</i> firmly to any broader clade is largely the result of the incomplete nature of specimens, particularly the lack of diagnostic cranial material. The most recent large-scale phylogenies of basal synapsid interrelationships do not consistently recover <i>Echinerpeton</i> in a stable position. Despite being one of the earliest known synapsids, the volatility of the phylogenetic position of <i>Echinerpeton</i> has resulted in its exclusion from many large-scale phylogenetic analyses. Here, we describe the first new remains of <i>Echinerpeton</i> since its initial discovery. RM 206866 includes substantial new cranial material, and we provide the first comprehensive description of its skull. Informative remains include a relatively complete parabasisphenoid complex. Additionally, we revisit the phylogenetic position of <i>Echinerpeton</i> using Bayesian inference and parsimony-based methods, confirming the taxon as a member of Ophiacodontidae.
DOI: 10.6084/m9.figshare.9767219.v1
title: Dataset from Host genetic diversity limits parasite success beyond agricultural systems: a meta-analysis

description: There is evidence that human activities are reducing the population genetic diversity of species worldwide. Given the prediction that parasites better exploit genetically homogeneous host populations, many species could be vulnerable to disease outbreaks. While agricultural studies have shown the devastating effects of infectious disease in crop monocultures, the widespread nature of this diversity–disease relationship remains unclear in natural systems. Here, we provide broad support that high population genetic diversity can protect against infectious disease by conducting a meta-analysis of 23 studies, with a total of 67 effect sizes. We found that parasite functional group (micro- or macroparasite) affects the presence of the effect and study setting (field or laboratory-based environment) influences the magnitude. Our study also suggests that host genetic diversity is overall a robust defence against infection regardless of host reproduction, parasite's host range, parasite diversity, virulence and the method by which parasite success was recorded. Combined, these results highlight the importance of monitoring declines of host population genetic diversity as shifts in parasite distributions could have devastating effects on at-risk populations in nature.