DOI: 10.5061/dryad.1j3t3
title: Data from: An overrepresentation of high frequencies in the mouse inferior colliculus supports the processing of ultrasonic vocalizations

description: Mice are of paramount importance in biomedical research and their
 vocalizations are a subject of interest for researchers across a wide
 range of health-related disciplines due to their increasingly important
 value as a phenotyping tool in models of neural, speech and language
 disorders. However, the mechanisms underlying the auditory processing of
 vocalizations in mice are not well understood. The mouse audiogram shows a
 peak in sensitivity at frequencies between 15-25 kHz, but weaker
 sensitivity for the higher ultrasonic frequencies at which they typically
 vocalize. To investigate the auditory processing of vocalizations in mice,
 we measured evoked potential, single-unit, and multi-unit responses to
 tones and vocalizations at three different stages along the auditory
 pathway: the auditory nerve and the cochlear nucleus in the periphery, and
 the inferior colliculus in the midbrain. Auditory brainstem response
 measurements suggested stronger responses in the midbrain relative to the
 periphery for frequencies higher than 32 kHz. This result was confirmed by
 single- and multi-unit recordings showing that high ultrasonic frequency
 tones and vocalizations elicited responses from only a small fraction of
 cells in the periphery, while a much larger fraction of cells responded in
 the inferior colliculus. These results suggest that the processing of
 communication calls in mice is supported by a specialization of the
 auditory system for high frequencies that emerges at central stations of
 the auditory pathway.
description: Auditory Nerve data file
 1 (file 1 out of 2)This Matlab MAT file
 contains single unit electrophysiological data recorded from mouse
 auditory nerve fibres from a sample of 15 animals. Data from individual
 animals are stored as columns in the cell array. For further information
 contact Dr. Jose A. Garcia Lazaro
 (jose.garcia-lazaro@ucl.ac.uk).AN_PooledData_01.matAuditory Nerve data file 2 (file 2 out of 2)This Matlab MAT file contains single unit electrophysiological data recorded from mouse auditory nerve fibers from a sample of 8 animals.AN_PooledData_02.matCochlear nucleus data file 1 (file 1 out of 8)These Matlab MAT files (8 in total) contain multiunit activity electrophysiological data recorded from the mouse dorsal cochlear nucleus. The data were collected using silicon electrode arrays (with recording sites arranged in 4 shanks with 8 sites per shank) from a population of 8 animals. There is one file for each animal and the file name represents the date the experiment was performed. Each file contains the “data” structured array whose size depends on the number of electrode penetrations performed in each experiment (at least five per animal). For further information contact Dr. Jose A. Garcia Lazaro (jose.garcia-lazaro@ucl.ac.uk).CN_Feb05a-2013_PooledData.matCochlear nucleus data file 2 (file 2 out of 8)CN_Apr04b-2013_PooledData.matCochlear nucleus data file 3 (file 3 out of 8)CN_Apr04a-2013_PooledData.matCochlear nucleus data file 4 (file 4 out of 8)CN_Apr08a-2013_PooledData.matCochlear nucleus data file 5 (file 5 out of 8)CN_May13-2013_PooledData.matCochlear nucleus data file 6 (file 6 out of 8)CN_May14a-2013_PooledData.matCochlear nucleus file 7 (file 7 out of 8)CN_May14b-2013_PooledData.matInferior colliculus data file 1 (file 1 out of 5)These Matlab MAT files (5 in total) contain multiunit activity electrophysiological data recorded from the mouse inferior colliculus. The data were collected using silicon electrode arrays (with recording sites arranged in 8 shanks with 8 sites per shank) from a sample of 5 animals. There is one file for each animal and the name of each file represents the date the experiment was performed. Each file contains the “data” structured array whose size depends on the number of electrode penetrations performed in each experiment (at least five per animal). For further information contact Dr. Jose A. Garcia Lazaro (jose.garcia-lazaro@ucl.ac.uk).Mar29b-2012-MUA_PooledData.matInferior colliculus data file 2 (file 2 out of 5)Mar15-2012-MUA_PooledData.matInferior colliculus data file 3 (file 3 out of 5)Apr02-2012-MUA_PooledData.matInferior colliculus data file 4 (file 4 out of 5)Mar30-2012-MUA_PooledData.matInferior colliculus data file 5 (5 out of 5)Mar29a-2012-MUA_PooledData.matCochlear nucleus data file 8 (file 8 out of 8)CN_Apr25-2013ss_PooledData.mat