cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.22560643.v1
title: Supplementary Material for: Behavioral changes after psychiatric genetic counseling: an exploratory study

description: Introduction: Though it is well established that genetic information does not produce behavior changes, there are limited data regarding whether genetic counseling can facilitate change in life-style and health behaviors that can result in improved health outcomes. Methods: To explore this issue, we conducted semi-structured interviews with eight patients who had lived experience of psychiatric illness, and who had received psychiatric genetic counseling (PGC). Using interpretive description, we used a constant comparative approach to data analysis. Results: Participants talked about how, prior to PGC, they held misconceptions and/or uncertainties about the causes of and protective behaviors associated with mental illness, which caused feelings of guilt, shame, fear and hopeless. Participants reported that PGC reframed things in a way that provided them a sense of agency over illness management, allowed a greater acceptance of illness, and provided release from some of the negative emotions associated with their initial framing of their illness, which seemed to be related to the self-reported increase in engagement in illness management behaviors and consequent improved mental health outcomes. Conclusion: This exploratory study provides data to support that through addressing emotions associated with perceived cause of illness and facilitating understanding of etiology and risk-reducing strategies, PGC may lead to an increase in behaviors, which protect mental health.
DOI: 10.6084/m9.figshare.13615850.v1
title: Tipping points in lowland agricultural landscapes

description: Dataset describing ecosystem service trends in the English county of Dorset, compiled as part of the following project: TPAL –Tipping Points in agricultural landscapes
DOI: 10.6084/m9.figshare.19959530.v1
title: Supplementary Material for: Use of fluoxetine to reduce weight in adults with overweight or obesity: Abridged republication of the Cochrane Systematic Review

description: Introduction: Using fluoxetine is one of many weight-loss strategies. A serotonin reuptake inhibitor indicated for depression believed to impact weight control by changing an individual’s appetite; however, its benefit-risk ratio is unclear. The aim of this review is to assess the efficacy and safety of fluoxetine in reducing weight in adults with overweight or obesity. Methods: We searched Cochrane Library, MEDLINE, Embase and other databases without language restrictions. Cochrane Collaboration tool and GRADE instrument assessed the risk of bias of randomised controlled trials and certainty of their evidence. We conducted random-effects meta-analyses and calculated the risk ratio/mean difference with 95% confidence intervals for the outcomes. Results: We included 19 trials (2,216 adults) and found that fluoxetine may reduce weight by −2.7 kg (95% CI −4 to −1.4; P &lt; 0.001) and body mass index (BMI) by −1.1 kg/m2 (95% CI −3.7 to 1.4), compared with placebo; however, it would cause approximately twice as many adverse events, such as dizziness, drowsiness, fatigue, insomnia or nausea. Conclusions: Although low-certainty evidence suggests that off-label fluoxetine may reduce weight, high-certainty research is needed to be conducted in the future to determine its effects exclusively as well as whether it is useful when combined with other agents. This article is based on a Cochrane Review published in the Cochrane Database of Systematic Reviews 2019, Issue 10, DOI: 10.1002/14651858. CD011688.pub2. Cochrane Reviews are regularly updated as new evidence emerges, and in response to feedback, it should be consulted for the most recent version of the review.
DOI: 10.6084/m9.figshare.28787798.v2
title: BSCCO - 4mm - Voltage-Current-Time PNG

description: Experimental tests were carried out to measure the AC losses of BSCCO tapes with 4mm wide. The used experimental setup comprises a sinusoidal voltage source (Keysight AC6804B) connected to a step-down transformer, with the secondary connected to the HTS tapes. Voltage taps are soldered to both sides of the HTS tape sample. A cancellation coil is employed to align the tape’s voltage and current, thereby reducing errors in computing the active power. The voltage signal undergoes an 80-fold amplification stage in the Low Noise Amplifier (LNA) before being visualized and acquired by an oscilloscope. For each current step, a 5-period signal is acquired 20 times, from which an average 5-period signal is derived. Each measurement step is repeated five times to mitigate noise. From these tests, AC voltage-current (V-I) characteristics and total AC losses are experimentally determined. In addition to the cancelation coil method, the voltage was also measured using a Lock-in amplifier, using the current as a phase reference.
DOI: 10.6084/m9.figshare.10013057.v1
title: LC50 table_FINAL.xlsx

description: Raw and transformed LC50 results for all toxicity testing trials of copper chloride and zinc chloride on five species of nematodes.
DOI: 10.4121/uuid:bbcb782b-5e89-4cb9-8b8e-d4fe42c26de1
title: Supplemental data for the paper: Stretching the limits of dynamic and quasi-static flow testing on cohesive limestone powders

description: This is the meta data as well as the raw experimental data for the paper: "Stretching the limits of dynamic and quasi-static flow testing on limestone powders" that published in Powder Technology.
DOI: 10.5522/04/16732687.v1
title: Perceived risk and condomless sex practice with commercial and non-commercial sexual partners of male migrant sex workers in London: Interview Schedule

description: Interview Schedule: face to face in-depth interview
DOI: 10.6084/m9.figshare.13516376.v1
title: Supplementary Material for: S100P Expression via DNA Hypomethylation Promotes Cell Growth in the Sessile Serrated Adenoma/Polyp-Cancer Sequence

description: <b><i>Background/Aims:</i></b> Sessile serrated adenomas/polyps (SSA/Ps) are a putative precursor lesion of colon cancer. Although the relevance of DNA hypermethylation in the SSA/P-cancer sequence is well documented, the role of DNA hypomethylation is unknown. We investigated the biological relevance of DNA hypomethylation in the SSA/P-cancer sequence by using 3-dimensional organoids of SSA/P. <b><i>Methods:</i></b> We first analyzed hypomethylated genes using datasets from our previous DNA methylation array analysis on 7 SSA/P and 2 cancer in SSA/P specimens. Expression levels of hypomethylated genes in SSA/P specimens were determined by RT-PCR and immunohistochemistry. We established 3-dimensional SSA/P organoids and performed knockdown experiments using a lentiviral shRNA vector. DNA hypomethylation at CpG sites of the gene was quantitated by MassARRAY analysis. <b><i>Results:</i></b> The mean number of hypomethylated genes in SSA/P and cancer in SSA/P was 41.6 ± 27.5 and 214 ± 19.8, respectively, showing a stepwise increment in hypomethylation during the SSA/P-cancer sequence. S100P, S100α2, PKP3, and MUC2 were most commonly hypomethylated in SSA/P specimens. The mRNA and protein expression levels of S100P, S100α2, and MUC2 were significantly elevated in SSA/P compared with normal colon tissues, as revealed by RT-PCR and immunohistochemistry, respectively. Among these, mRNA and protein levels were highest for S100P. Knockdown of the S100P gene using a lentiviral shRNA vector in 3-dimensional SSA/P organoids inhibited cell growth by &gt;50% (<i>p</i> &lt; 0.01). The mean diameter of SSA/P organoids with S100P gene knockdown was significantly smaller compared with control organoids. MassARRAY analysis of DNA hypomethylation in the S100P gene revealed significant hypomethylation at specific CpG sites in intron 1, exon 1, and the 5′-flanking promoter region. <b><i>Conclusion:</i></b> These results suggest that DNA hypomethylation, including S100P hypomethylation, is supposedly associated with the SSA/P-cancer sequence. S100P overexpression via DNA hypomethylation plays an important role in promoting cell growth in the SSA/P-cancer sequence.
DOI: 10.6084/m9.figshare.14465133.v1
title: Supplementary Material for: Carbon Monoxide Poisoning and Chronic Kidney Disease Risk: A Nationwide, Population-Based Study

description: <b><i>Introduction:</i></b> Patients with carbon monoxide poisoning (COP) commonly have long-term morbidities. However, it is not known whether patients with COP exhibit an increased risk of developing chronic kidney disease (CKD) and whether hyperbaric oxygen therapy (HBOT) alters this risk. <b><i>Methods:</i></b> This study identified 8,618 patients who survived COP and 34,464 propensity score-matched non-COP patients from 2000 to 2013 in a nationwide administrative registry. The primary outcome was the development of CKD. The association between COP and the risk of developing CKD was estimated using a Cox proportional hazards regression model; the cumulated incidence of CKD among patients stratified by HBOT was evaluated using a Kaplan-Meier analysis. <b><i>Results:</i></b> After adjusting for covariates, the risk of CKD was 6.15-fold higher in COP patients than in non-COP controls. Based on the subgroup analyses, regardless of demographic characteristics, environmental factors, and comorbidities, the COP cohort exhibited an increased risk of developing CKD compared with the controls. The cumulative incidence of CKD in COP patients did not differ between the HBOT and non-HBOT groups (<i>p</i> = 0.188). <b><i>Conclusions:</i></b> COP might be an independent risk factor for developing CKD. Thus, clinicians should enhance the postdischarge follow-up of kidney function among COP patients.
DOI: 10.6084/m9.figshare.11283758.v2
title: Global Hydropower Database (GHD)

description: GHD comprises 8748 hydropower plants distributed across 134 countries.
DOI: 10.6084/m9.figshare.27823281.v1
title: Data of temporal variation of concentrations of PM2.5, BC, SO2, NO2, and CO, and meteorological condition in Hangzhou

description: Thedata of temporal variation of concentrations of PM2.5, BC, SO2, NO2, and CO, and meteorological conditions in Hangzhou, during the period of 2022-12-04 to 2024-01-15.
DOI: 10.6084/m9.figshare.28611935.v1
title: Data used in: "Seed-dispersing vertebrates and the abiotic environment shape functional diversity of the pantropical Annonaceae"

description: <b>Data for</b>:<b> </b>‘Seed-dispersing vertebrates and the abiotic environment shape functional diversity of the pantropical Annonaceae’<b>Article </b><b>DOI</b>: 10.1111/nph.70113<br><br><b>Journal</b>: New<b> </b>Phytologist<br><b>Authors</b>:<b> </b>Andressa Cabral, Irene Bender, Thomas Couvreur, Søren Faurby, Oskar Hagen, Isabell Hensen, Ingolf Kühn, Carlos Rodriguez-Vaz, Hervé Sauquet, Joseph A. Tobias & Renske E. Onstein<br>________________________________________________________________________________<br><b>FOLDER STRUCTURE</b>Data/README.pdf: Documentation for dataset usage<br>Annonaceae_trait_matrix: Trait matrix for Annonaceae (raw data)<br>Annonaceae_reference_entries: References for data entries<br>Annonaceae_reference_details: Full citation details<br>sem_f50_bc: SEM input; frugivorous species, botanical countries<br>sem_f50_grid: SEM input; frugivorous species, grid cells<br>sem_f0_bc: SEM input; non-frugivorous species, botanical countries<br>sem_f0_grid: SEM input; non-frugivorous species, grid cells<br>traits_annon_FC: Annonaceae trait data used in the fourth-corner analyses<br>traits_mammals_FC: Trait data for frugivorous mammals used in the fourth-corner analyses<br>binary_cooccurrence_FC: Co-occurrence matrix (Annonaceae × frugivorous mammals) for fourth-corner analyses<br>TDWG_level3_shp/ : Shapefile of botanical countries<br>
DOI: 10.6084/m9.figshare.28787948.v1
title: XRD crystallographic results after heat treatment at different temperatures for 30 minutes after coating the 3Y-TZP surface with acetate.

description: <b>To enhance the osseointegration capacity of yttria-stabilized tetragonal zirconia (Y-TZP) ceramics, this study employed a dip-coating technique to construct calcium (Ca²⁺), magnesium (Mg²⁺), strontium (Sr²⁺), and zinc (Zn²⁺) acetate films on the material surface, followed by heat treatment at elevated temperatures. The surface morphology, chemical composition, and in vitro biological behavior of the modified Y-TZP were systematically evaluated. Results demonstrated that Ca²⁺, Mg²⁺, and Sr²⁺ ion implantation layers, with a depth of approximately 500 nm, were successfully formed on the heat-treated Y-TZP surface. All ion-implanted samples exhibited stable metal oxide nanoparticles on their surfaces and sustained release of metal ions. Although Mg²⁺ implantation reduced the flexural strength of Y-TZP, it remained at 723.18 ± 128.24 MPa. In vitro cellular experiments revealed that metal ion implantation significantly promoted the adhesion, proliferation, and osteogenic differentiation of human bone marrow mesenchymal stem cells. These findings confirm that heat-treated bioactive ion implantation is an effective surface modification strategy to enhance the osteogenic properties of Y-TZP, offering economic feasibility and practical applicability.</b>
DOI: 10.6084/m9.figshare.26067691.v1
title: Impacts of warming and nutrient enrichment on the fate and effects of nanoplastics in a freshwater food web

description: Source data for Figures 2-6 in the manuscript.
DOI: 10.6084/m9.figshare.17918450.v1
title: E. sideroxylon v's E. melliodora synteny and rearrangements

description: tsv file describing all syntenic, rearranged, and not-aligned regions bewteen E. sideroxylon (reference) and E. milliodora (query).<br>These are the results of aligning the genomes with nucmer (MUMmer) and analysiing alignments with SyRI.
DOI: 10.6084/m9.figshare.20547933.v1
title: Supplementary Material for: Expansion of Phenotypically Altered Dendritic Cell Populations in the Small Airways and Alveolar Parenchyma in Patients with Chronic Obstructive Pulmonary Disease

description: Contrasting the antigen-presenting dendritic cells (DCs) in the conducting airways, the alveolar DC populations in human lungs have remained poorly investigated. Consequently, little is known about how alveolar DCs are altered in diseases such as chronic obstructive pulmonary disease (COPD). This study maps multiple tissue DC categories in the distal lung across COPD severities. Specifically, single-multiplex immunohistochemistry was applied to quantify langerin/CD207<sup>+</sup>, CD1a<sup>+</sup>, BDCA2<sup>+</sup>, and CD11c<sup>+</sup> subsets in distal lung compartments from patients with COPD (GOLD stage I–IV) and never-smoking and smoking controls. In the alveolar parenchyma, increased numbers of CD1a<sup>+</sup>langerin<sup>−</sup> (<i>p</i> &lt; 0.05) and BDCA-2<sup>+</sup> DCs (<i>p</i> &lt; 0.001) were observed in advanced COPD compared with controls. Alveolar CD11c<sup>+</sup> DCs also increased in advanced COPD (<i>p</i> &lt; 0.01). In small airways, langerin<sup>+</sup> and BDCA-2<sup>+</sup> DCs were also significantly increased. Contrasting the small airway DCs, most alveolar DC subsets frequently extended luminal protrusions. Importantly, alveolar and small airway langerin<sup>+</sup> DCs in COPD lungs displayed site-specific marker profiles. Further, multiplex immunohistochemistry with single-cell quantification was used to specifically profile langerin DCs and reveal site-specific expression patterns of the maturation and activation markers S100, fascin, MHC2, and B7. Taken together, our results show that clinically advanced COPD is associated with increased levels of multiple alveolar DC populations exhibiting features of both adaptive and innate immunity phenotypes. This expansion is likely to contribute to the distal lung immunopathology in COPD patients.
DOI: 10.6084/m9.figshare.3566592.v1
title: Appendix A. Covariance stucture of leaf, stem, and root traits for 54 woody species.

description: Covariance stucture of leaf, stem, and root traits for 54 woody species.
DOI: 10.6084/m9.figshare.28554299.v1
title: Trying To Conceive Misconceptions Survey 2024

description: This anonymous survey was designed in September 2023 to begin thinking about making a public resource about approaching parenthood. It ran online for the duration of the (Mis)Conceptions project (until February 2025), but it was particularly promoted at the onset of the project, to gather initial ideas for public engagement. It was circulated via social media (Twitter and Instagram) and a project website. 64 people responded to a 10-question survey, asking for people's feelings, rituals, and thoughts during the process of trying to conceive.
DOI: 10.6084/m9.figshare.28621547.v1
title: Six human cases of spatial metabolomics

description: Spatial metabolomics data from six clinical hepatocellular carcinoma (HCC) patients
DOI: 10.15468/dl.z3pe3m
title: Occurrence Download

description: A dataset containing 1800 species occurrences available in GBIF matching the query:
{
 "and" : [
 "HasGeospatialIssue is false",
 "HasCoordinate is true",
 "OccurrenceStatus is Present",
 {
 "not" : {
 "BasisOfRecord" : [
 "is one of (Observation, Human Observation, Machine Observation, Living Specimen)"
 ]
 }
 },
 "TaxonKey is Polydrusus cervinus (Linnaeus, 1758)"
 ]
}

 The dataset includes 1800 records from 72 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0009559-250426092105405/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.6084/m9.figshare.28831442.v1
title: Differentially expressed genes used for enrichment analysis

description: Differentially expressed genes used for enrichment analysis
DOI: 10.6084/m9.figshare.13241507.v1
title: Dataset #1 THYM Significant

description: Dataset #1 THYM Significant
DOI: 10.6084/m9.figshare.13636817.v1
title: Supplementary Material for: Altered Immune Regulation of Dendritic Cells and Enhanced Cytokine Production of T Cells in the Pathogenesis of Eosinophilic Chronic Rhinosinusitis

description: <b><i>Introduction:</i></b> Eosinophilic chronic rhinosinusitis (ECRS) is a refractory chronic disease defined by recurrent nasal polyps with severe eosinophilic infiltration. This is mainly due to enhanced type 2-dominant immune responses, but the underlying mechanism is still not fully understood. <b><i>Objective and Methods:</i></b> In the present study, we aimed to determine the characteristics of dendritic cells (DCs) and cytokine profiles of T cells in the peripheral blood of individuals with ECRS and age- and sex-matched healthy controls (HC). <b><i>Results and Conclusion:</i></b> The ratios of myeloid (m)DC1s to DCs and PD-L1<sup>+</sup> mDC1s to mDC1s were higher in ECRS patients than in HC. The proportions of plasmacytoid (p)DCs in DCs, and human leukocyte antigen-DR<sup>+</sup> pDCs and ILT3<sup>+</sup> pDCs in pDCs were lower in ECRS patients than in HC. In a characterization of T cells, IL-4<sup>+</sup>CD4<sup>+</sup>, IFN-γ<sup>+</sup>CD4<sup>+</sup>, IL-4<sup>+</sup>IFN-γ<sup>+</sup>CD4<sup>+</sup>, IL-4<sup>+</sup>Foxp3<sup>+</sup>CD4<sup>+</sup>, IFN-γ<sup>+</sup>Foxp3<sup>+</sup>CD4<sup>+</sup>, IFN-γ<sup>+</sup>IL-4<sup>−</sup>Foxp3<sup>−</sup>CD4<sup>+</sup>, IL-4<sup>+</sup>CD8<sup>+</sup>, IL-4<sup>+</sup>IFN-γ<sup>+</sup>CD8<sup>+</sup>, and IL-4<sup>+</sup>Foxp3<sup>+</sup>CD8<sup>+</sup> T-cell populations were significantly higher in ECRS patients than in HC. These results suggest that the enhanced immune regulation of mDC1, diminished capacity of pDCs, and increased proportion of the T-cell phenotypes in peripheral blood might be factors in ECRS pathogenesis.
DOI: 10.6084/m9.figshare.5873451.v1
title: GRID release 2018-02-08

description: A database of over 85,000 research institutes with persistent identifiers.<br>Institutes added from various sources including the US, China, France, Germany, Netherlands, Australia and other countries.<br>Metadata:* US dependencies (American Samoa, Micronesia, Guam, Marshall Islands, Northern Mariana Islands, Puerto Rico, U.S. Minor Outlying Islands, U.S. Virgin Islands) are treated as states of the US.* Chinese dependency Hong Kong is treated as a state/region of China.* Changed country name from "Palestinian Territories" to UN and ISO standard "State of Palestine".* Created parent-child relationships for around 200 multinational companies.<br>QA<br>* Review of all EU bodies and agencies.* Review of parent-child relationships of Sea Grant and Space Grant organisations.* Adaption of country name changes: Czech Republic is now Czechia.* Review of potential duplicates.<br>Note: the geonames information is from geonames.org and licensed as CC-BY 3.0.<br><br>
DOI: 10.6084/m9.figshare.24125127.v1
title: Supplementary Material for: DNA methylation pattern in somatotroph pituitary neuroendocrine tumors

description: Introduction. Growth hormone secretion by sporadic somatotroph neuroendocrine pituitary tumors (PitNETs) is major cause of acromegaly. These tumors are relatively heterogenous in terms of histopathological and molecular features. Our previous transcriptomic profiling of somatotroph tumors revealed three distinct molecular subtypes. This study was aimed to investigate difference in DNA methylation pattern in subtypes of somatotroph PitNETs and its role in distinctive gene expression. Methods. Genome-wide DNA methylation was investigated in 48 somatotroph PitNETs with EPIC microarrays. Gene expression was assessed with RNAseq. Bisulfite pyrosequencing and qRT-PCR were used for verifying results of DNA methylation and gene expression. Results. Clustering tumor samples based on methylation data reflected the transcriptome-related classification. Subtype 1 tumors are densely granulated without GNAS mutation, characterized by high expression of NR5A1 (SF-1) and GIPR. The expression of both genes is correlated with specific methylation of gene body and promoter. This subtype has lower methylation level of 5’ gene regions and CpG islands than the remaining tumors. Subtype 2 PitNETs are densely granulated, frequently GNAS-mutated while those in subtype 3 are mainly sparsely granulated. Methylation/expression analysis indicates that ~50% genes located in differentially methylated regions are those differentially expressed between tumor subtypes. Correlation analysis revealed DNA methylation-controlled genes including CDKN1B, CCND2, EBF3, CDH4, CDH12, MGMT, STAT5A, PLXND1, PTPRE, MMP16 and genes encoding ion channels and semaphorins. Conclusion. DNA methylation profiling confirmed the existence of three molecular subtypes of somatotroph PitNETs. High expression of NR5A1 and GIPR in subtype 1 tumors is correlated with specific methylation of both genes.
DOI: 10.6084/m9.figshare.25857304.v1
title: Supplementary Data S3.xlsx

description:  <strong>Supplementary Data S3.xlsx</strong>