cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.8197829
title: Supplementary Material for: Exploration of the Product of the 5-Point Investigator’s Global Assessment and Body Surface Area (IGA × BSA) as a Practical Minimal Disease Activity Goal in Patients with Moderate-to-Severe Psoriasis

description: <b><i>Background/Aims:</i></b> In the treat-to-target era, psoriasis disease activity measures that can be easily performed in routine clinical practice are needed. This retrospective pooled analysis explored cutoff values of the product of the 5-point Investigator’s Global Assessment and percentage of affected body surface area (IGA × BSA) correlating with achievement of minimal disease activity (MDA). <b><i>Methods:</i></b> Post hoc analysis of the phase 3 clinical trials ERASURE, FIXTURE, FEATURE, and JUNCTURE was conducted to determine associations between IGA × BSA and 2 MDA definitions (Psoriasis Area and Severity Index [PASI] 90 and Dermatology Life Quality Index [DLQI] 0/1, or PASI score ≤1 or BSA &lt;3%) in patients with moderate-to-severe psoriasis receiving secukinumab 300 mg. For each definition of MDA, a range of possible cutoff values of IGA × BSA was examined at each time point. The optimal cutoff value was determined using Youden index (YI), calculated as (sensitivity + specificity – 1). <b><i>Results:</i></b> For MDA defined as PASI 90 and DLQI 0/1, optimal IGA × BSA cutoffs were 2.10 at week 12 (YI, 0.60; sensitivity, 0.78; specificity, 0.82), 1.02 at week 24 (YI, 0.55; sensitivity, 0.73; specificity, 0.82), and 1.00 at week 52 (YI, 0.65; sensitivity, 0.79; specificity, 0.86). For MDA defined as PASI score ≤1 or BSA &lt;3%, optimal IGA × BSA cutoffs were 2.98 at week 12 (YI, 0.91; sensitivity, 0.99; specificity, 0.92), 2.80 at week 24 (YI, 0.94; sensitivity, 0.99; specificity, 0.95), and 3.00 at week 52 (YI, 0.96; sensitivity, 1.00; specificity, 0.96). <b><i>Conclusion:</i></b> IGA × BSA could be a valid measure highly associated with achievement of MDA.
DOI: 10.6084/m9.figshare.8197823
title: Companion of the Improving Fairness in a Large Scale HTC System Through Workload Analysis and Simulation article

description: This archive is an experimental artifact associated to the paper entitled 
"Improving Fairness in a Large Scale HTC System Through Workload Analysis and Simulation" published in the proceedings of the Euro-Par'19 conference.<br>
DOI: 10.6084/m9.figshare.8197688
title: volatility.xlsxData of article

description: Volatility data of markets
DOI: 10.6084/m9.figshare.8197697
title: return

description: daily return of series
DOI: 10.6084/m9.figshare.8197619
title: Assembled sequences and sequence annotation for Juglans hybrid

description: Assembled sequences and sequence annotation for Juglans hybrid
DOI: 10.6084/m9.figshare.8197577
title: Supplementary Material for: The Recurrence of Onychocryptosis when Treated with Phenolization: Does Phenol Application Time Play a Role? A Follow-Up Study on 622 Procedures

description: <b><i>Introduction:</i></b> Chemical matricectomy using phenol (CMP) is a recognized treatment option for onychocryptosis. However, the appropriate phenol application time to achieve nail matrix destruction is still unknown. Optimal ablation leads to low recurrence rates. The aim of this research was to assess the recurrence rate of onychocryptosis in a cohort of 622 consecutive patients treated with a 4-min CMP. <b><i>Methods:</i></b> We recruited all patients undergoing a 4-min CMP for onychocryptosis at the Istituto Podologico Italiano, Rome, Italy, in 2008–2017. Postoperative follow-up visits were set at 24 h, 7, 14, 21, and 28 days, 6 months, and 1 year after surgery. We used adjusted logistic regression to evaluate the potential risk factors for the disease recurrence including age, gender, toe shape, comorbidities, and disease localization. <b><i>Results:</i></b> The risk of recurrence in all patients treated with a 4-min CMP was 1.1% (<i>n</i> = 622, 95% CI = 0.5%–2.3%). In the subgroup of patients with cardiovascular disease (<i>n</i> = 39) the recurrence risk was 5.1% (95% CI = 0.61–7.3). Young age was also associated with increased odds of recurrence (<i>p</i> = 0.036). <b><i>Conclusion:</i></b> In this observational study, 4 min with no interruptions seems to be the appropriate application time of phenol when using CMP for the treatment of onychocryptosis. A randomized controlled trial should be carried out to confirm our results.
DOI: 10.6084/m9.figshare.8197565
title: Supplementary Material for: A Common Genetic Variation in Langerin (CD207) Compromises Cellular Uptake of <b><i>Staphylococcus aureus</i></b>

description: Langerhans cells are key sentinel cells of the skin and mucosal lining. They sense microorganisms through their repertoire of pattern-recognition receptors to mount and direct appropriate immune responses. We recently demonstrated that human Langerhans cells interact with the Gram-positive pathogen <i>Staphylococcus aureus</i> through the Langerhans cell-specific receptor langerin (CD207). It was previously hypothesized that two linked single nucleotide polymorphisms (SNPs; N288D and K313I) in the carbohydrate recognition domain of langerin would affect interaction with microorganisms. We show that recognition of <i>S. aureus</i> by recombinant langerin molecules is abrogated in the co-inheriting SNP variant, which is mainly explained by the N288D SNP and further enhanced by K313I. Moreover, introduction of SNP N288D in ectopically-expressed langerin affected cellular distribution of the receptor such that langerin displayed enhanced plasma membrane<i></i>expression. Despite this increased binding of <i>S. aureus</i> by the langerin double SNP variant, uptake of bacteria by this langerin variant was compromised. Our findings indicate that in a proportion of the human population, the recognition and uptake of <i>S. aureus</i> by Langerhans cells may be affected, which could have important consequences for proper immune activation and <i>S. aureus</i>-associated disease.
DOI: 10.6084/m9.figshare.8197526
title: DEPTOR inhibits cell proliferation and confers sensitivity to dopamine agonist in pituitary adenoma

description: <b>DEPTOR inhibits cell proliferation and confers sensitivity to dopamine agonist in pituitary adenoma</b>
DOI: 10.6084/m9.figshare.8197520
title: Decoupling of nutrient cycles in a Eucalyptus woodland under elevated CO2

description: Dataset from "Decoupling of nutrient cycles in a Eucalyptus woodland under elevated CO2", published in Journal of Ecology
DOI: 10.6084/m9.figshare.8197487
title: Human epigenetic ageing is logarithmic with time across the entire lifespan

description: Epigenetic changes during ageing have been characterized by multiple epigenetic clocks that allow the prediction of chronological age based on methylation status. Despite their accuracy and utility, epigenetic age biomarkers leave many questions about epigenetic ageing unanswered. Specifically, they do not permit the unbiased characterization of non-linear epigenetic ageing trends across entire life spans, a critical question underlying this field of research. Here we provide an integrated framework to address this question. Our model, inspired from evolutionary models, is able to account for acceleration/deceleration in epigenetic changes by fitting an individual’s model age, the epigenetic age, which is related to chronological age in a non-linear fashion. Application of this model to DNA methylation data measured across broad age ranges, from before birth to old age, and from two tissue types, suggests a universal logarithmic trend characterizes epigenetic ageing across entire lifespans.
DOI: 10.6084/m9.figshare.8197487.v2
title: Human epigenetic ageing is logarithmic with time across the entire lifespan

description: Epigenetic changes during ageing have been characterized by multiple epigenetic clocks that allow the prediction of chronological age based on methylation status. Despite their accuracy and utility, epigenetic age biomarkers leave many questions about epigenetic ageing unanswered. Specifically, they do not permit the unbiased characterization of non-linear epigenetic ageing trends across entire life spans, a critical question underlying this field of research. Here we provide an integrated framework to address this question. Our model, inspired from evolutionary models, is able to account for acceleration/deceleration in epigenetic changes by fitting an individual’s model age, the epigenetic age, which is related to chronological age in a non-linear fashion. Application of this model to DNA methylation data measured across broad age ranges, from before birth to old age, and from two tissue types, suggests a universal logarithmic trend characterizes epigenetic ageing across entire lifespans.
DOI: 10.6084/m9.figshare.8197487.v1
title: Human Epigenetic Aging is Logarithmic with Time across the Entire LifeSpan

description: Epigenetic changes during aging have been characterized by multiple epigenetic clocks, that allow the prediction of chronological age based on methylation status. Despite their accuracy and utility, epigenetic age biomarkers leave many questions about epigenetic aging unanswered. Specifically, they do not permit the unbiased characterization of non-linear epigenetic aging trends across entire life spans, a critical question underlying this field of research. Here we a provide an integrated framework to address this question. Our model, inspired from evolutionary models, is able to account for acceleration/deceleration in epigenetic changes by fitting an individual’s model age, the epigenetic age, which is related to chronological age in a non-linear fashion. Application of this model to DNA methylation data measured across broad age ranges, from before birth to old age, and from two tissue types, suggests a universal logarithmic trend characterizes epigenetic aging across entire lifespans.
DOI: 10.6084/m9.figshare.8197352
title: Supplementary table 1.docx

description: <b>DEPTOR inhibits cell proliferation and confers
sensitivity to dopamine agonist in pituitary adenoma</b><br>
DOI: 10.6084/m9.figshare.8197382
title: Supplementary Material for: Intralesional Triamcinolone for Fistulous Tracts in Hidradenitis Suppurativa: An Uncontrolled Prospective Trial with Clinical and Ultrasonographic Follow-Up

description: <b><i>Background:</i></b> There is little evidence on the use of intralesional triamcinolone (ILT) for managing fistulous tracts in hidradenitis suppurativa (HS). <b><i>Objective:</i></b> To assess the clinical and ultrasound response to ILT for single fistulous lesions in HS patients. <b><i>Methods:</i></b> A prospective open-label study was conducted to assess response to ILT (40 mg/mL) for fistulous tracts in HS. Consecutive patients (Hurley II stage exclusively) presenting to our department were recruited from August 2016 to August 2018. They received a single injection of ILT as the sole treatment. Lesions were assessed clinically and by ultrasound at baseline and 90 days. <b><i>Results:</i></b> Of the 53 included HS patients with fistulous tracts, 36 (67.9%) were women, 30 (56.6%) were smokers, and 36 (67.9%) were obese or overweight (body mass index ≥25). Median Sartorius score was 9.0 (IQR 9.0–36.0), and median duration of the lesion treated was 6 months (IQR 3.0–12.0). Fistulous tracts were injected with 0.5 mL triamcinolone 40 mg/mL. Seven patients were lost to follow-up. At 90 days, 20 (43.5%) lesions showed clinical and ultrasound resolution, 13 (28.3%) showed only clinical resolution while persisting on ultrasound, and 13 (28.3%) persisted both clinically and on ultrasound. Mean clinical size decreased from 17.0 to 5.1 mm (<i>p</i> &lt; 0.0001), while mean length on ultrasound decreased from 16.0 to 8.6 mm (<i>p</i> &lt; 0.0001). <b><i>Limitations:</i></b> Small sample size and no control group. <b><i>Conclusions:</i></b> Our study suggests that ILT is beneficial for small fistulous tracts in HS.
DOI: 10.6084/m9.figshare.8197238
title: Figure 2b and Figure 3

description: The data for Figure 2b and Figure 3 in the manuscript. The prefix "Data_time_ndtime_viscibc_viscm_strainrateibc_strainratem_fibc_fm" specifies the time evolution of average IBC viscosity, average mantle viscosity , average IBC strain rate, average mantle strain rate, average f-factor in IBC and average f-factor in lunar mantle, whereas the prefix "Data_time_ndtime_Tibc_Tm" specifies the time evolution of average IBC temperature and average mantle temperature. The first two columns are time (Myr) and dimensionless time. The postfix of file name specifies the case name.
DOI: 10.6084/m9.figshare.8197232
title: Figure 2a

description: The data for the time evolution of the fraction of overturned IBC, which are plotted as Figure 2a in the manuscript. In the data files, the first column, the second column and the third column are dimensional time (Myr), dimensionless time and the fraction of overturned IBC respectively.
DOI: 10.6084/m9.figshare.8197202
title: Number of 3-gram Overlaps

description: duplicate 3-grams
DOI: 10.6084/m9.figshare.8197196
title: 3-grams

description: Duplicated 3-grams
DOI: 10.6084/m9.figshare.8197109
title: Additional file 9: of Transcriptome Analysis of Gene Families Involved in Chemosensory Function in Spodoptera littoralis (Lepidoptera: Noctuidae)

description: S. littoralis IR protein sequences. Contains updated amino acid sequences for all annotated S. littoralis ionotropic receptors. (TXT 11 kb)
DOI: 10.6084/m9.figshare.8197109.v1
title: Additional file 9: of Transcriptome Analysis of Gene Families Involved in Chemosensory Function in Spodoptera littoralis (Lepidoptera: Noctuidae)

description: S. littoralis IR protein sequences. Contains updated amino acid sequences for all annotated S. littoralis ionotropic receptors. (TXT 11 kb)
DOI: 10.6084/m9.figshare.8197103
title: Additional file 7: of Transcriptome Analysis of Gene Families Involved in Chemosensory Function in Spodoptera littoralis (Lepidoptera: Noctuidae)

description: S. littoralis GR protein sequences. Contains updated amino acid sequences for all annotated S. littoralis gustatory receptors. (TXT 6 kb)
DOI: 10.6084/m9.figshare.8197100
title: Additional file 6: of Transcriptome Analysis of Gene Families Involved in Chemosensory Function in Spodoptera littoralis (Lepidoptera: Noctuidae)

description: Candidate Chemosensory Gene Abundance Estimates. Contains “FPKM” and “estimated mapped reads” values for candidate chemosensory gene transcripts, sorted by chemosensory gene family, sex and tissue type. (XLSX 47 kb)
DOI: 10.6084/m9.figshare.8197097
title: Additional file 5: of Transcriptome Analysis of Gene Families Involved in Chemosensory Function in Spodoptera littoralis (Lepidoptera: Noctuidae)

description: S. littoralis OR protein sequences. Contains updated amino acid sequences for all annotated S. littoralis odorant receptors. (TXT 24 kb)
DOI: 10.6084/m9.figshare.8197103.v1
title: Additional file 7: of Transcriptome Analysis of Gene Families Involved in Chemosensory Function in Spodoptera littoralis (Lepidoptera: Noctuidae)

description: S. littoralis GR protein sequences. Contains updated amino acid sequences for all annotated S. littoralis gustatory receptors. (TXT 6 kb)
DOI: 10.6084/m9.figshare.8197100.v1
title: Additional file 6: of Transcriptome Analysis of Gene Families Involved in Chemosensory Function in Spodoptera littoralis (Lepidoptera: Noctuidae)

description: Candidate Chemosensory Gene Abundance Estimates. Contains “FPKM” and “estimated mapped reads” values for candidate chemosensory gene transcripts, sorted by chemosensory gene family, sex and tissue type. (XLSX 47 kb)
DOI: 10.6084/m9.figshare.8197088
title: Additional file 2: of Transcriptome Analysis of Gene Families Involved in Chemosensory Function in Spodoptera littoralis (Lepidoptera: Noctuidae)

description: Bioinformatic Information for Male and Female Transcriptomes. Contains basic information on the transcriptomes at various stages of processing, including total number of sequences, mean sequence length, N50 and other parameters. (XLSX 35 kb)
DOI: 10.6084/m9.figshare.8197097.v1
title: Additional file 5: of Transcriptome Analysis of Gene Families Involved in Chemosensory Function in Spodoptera littoralis (Lepidoptera: Noctuidae)

description: S. littoralis OR protein sequences. Contains updated amino acid sequences for all annotated S. littoralis odorant receptors. (TXT 24 kb)
DOI: 10.6084/m9.figshare.8197079
title: Additional file 22: of Transcriptome Analysis of Gene Families Involved in Chemosensory Function in Spodoptera littoralis (Lepidoptera: Noctuidae)

description: PCR primer sequences and expected fragment sizes. (XLSX 10 kb)
DOI: 10.6084/m9.figshare.8197070
title: Additional file 20: of Transcriptome Analysis of Gene Families Involved in Chemosensory Function in Spodoptera littoralis (Lepidoptera: Noctuidae)

description: S. littoralis SNMP protein sequences. Contains updated amino acid sequences for all annotated S. littoralis sensory neuron membrane proteins. (TXT 1 kb)
DOI: 10.6084/m9.figshare.8197067
title: Additional file 1: of Transcriptome Analysis of Gene Families Involved in Chemosensory Function in Spodoptera littoralis (Lepidoptera: Noctuidae)

description: Metrics on Biological Samples. Includes input RNA concentration, purity, and also number of quality controlled and filtered read pairs per sequenced samples. (XLSX 39 kb)
DOI: 10.6084/m9.figshare.8197052
title: Additional file 17: of Transcriptome Analysis of Gene Families Involved in Chemosensory Function in Spodoptera littoralis (Lepidoptera: Noctuidae)

description: S. littoralis CYP protein sequences. Contains updated amino acid sequences for all annotated S. littoralis Cytochrome p450 proteins. (TXT 41 kb)
DOI: 10.6084/m9.figshare.8197037
title: Additional file 14: of Transcriptome Analysis of Gene Families Involved in Chemosensory Function in Spodoptera littoralis (Lepidoptera: Noctuidae)

description: S. littoralis CXE/CCE protein sequences. Contains updated amino acid sequences for all annotated S. littoralis carboxy/cholinesterase proteins. (TXT 29 kb)
DOI: 10.6084/m9.figshare.8197019
title: Additional file 12: of Transcriptome Analysis of Gene Families Involved in Chemosensory Function in Spodoptera littoralis (Lepidoptera: Noctuidae)

description: S. littoralis CSP protein sequences. Contains updated amino acid sequences for all annotated S. littoralis chemosensory proteins. (TXT 2 kb)
DOI: 10.6084/m9.figshare.8197022
title: Additional file 1: of Liver function assessment using indocyanine green plasma disappearance rate in a young male with icteric leptospirosis: a case report

description: Numeric values of indocyanine green plasma disappearance rates (ICG-PDR) and serum total bilirubin as well as alanine aminotransferase (ALAT) levels during hospitalization and a 3-month follow-up period. (XLSX 9 kb)
DOI: 10.6084/m9.figshare.8197022.v1
title: Additional file 1: of Liver function assessment using indocyanine green plasma disappearance rate in a young male with icteric leptospirosis: a case report

description: Numeric values of indocyanine green plasma disappearance rates (ICG-PDR) and serum total bilirubin as well as alanine aminotransferase (ALAT) levels during hospitalization and a 3-month follow-up period. (XLSX 9 kb)
DOI: 10.6084/m9.figshare.8197019.v1
title: Additional file 12: of Transcriptome Analysis of Gene Families Involved in Chemosensory Function in Spodoptera littoralis (Lepidoptera: Noctuidae)

description: S. littoralis CSP protein sequences. Contains updated amino acid sequences for all annotated S. littoralis chemosensory proteins. (TXT 2 kb)
DOI: 10.6084/m9.figshare.8197010
title: Additional file 10: of Transcriptome Analysis of Gene Families Involved in Chemosensory Function in Spodoptera littoralis (Lepidoptera: Noctuidae)

description: S. littoralis OBP protein sequences. Contains updated amino acid sequences for all annotated S. littoralis odorant binding proteins. (TXT 9 kb)
DOI: 10.6084/m9.figshare.8197010.v1
title: Additional file 10: of Transcriptome Analysis of Gene Families Involved in Chemosensory Function in Spodoptera littoralis (Lepidoptera: Noctuidae)

description: S. littoralis OBP protein sequences. Contains updated amino acid sequences for all annotated S. littoralis odorant binding proteins. (TXT 9 kb)
DOI: 10.6084/m9.figshare.8196986
title: Additional file 2: of Assessment of risk based on variant pathways and establishment of an artificial neural network model of thyroid cancer

description: Table S2. The clinical information of thyroid cancer samples downloaded from the GEO database. (XLSX 25 kb)
DOI: 10.6084/m9.figshare.8196986.v1
title: Additional file 2: of Assessment of risk based on variant pathways and establishment of an artificial neural network model of thyroid cancer

description: Table S2. The clinical information of thyroid cancer samples downloaded from the GEO database. (XLSX 25 kb)
DOI: 10.6084/m9.figshare.8196977
title: Additional file 1: of Assessment of risk based on variant pathways and establishment of an artificial neural network model of thyroid cancer

description: Table S1. The clinical information of thyroid cancer samples downloaded from the Cancer Genome Atlas (TCGA) database. (XLSX 136 kb)
DOI: 10.6084/m9.figshare.8196932
title: Additional file 8: of WhoGEM: an admixture-based prediction machine accurately predicts quantitative functional traits in plants

description: Code 2. R code for the ProvenancePredictor cross-validation function (R (txt) (R 13 kb)
DOI: 10.6084/m9.figshare.8196929
title: MOESM4 of Surface sterilization methods impact measures of internal microbial diversity in ticks

description: Additional file 4: Table S3. OTU abundance without contaminants and intracellular endosymbiont retrieved in cuticle smears, wash samples, and ethanol-treated whole-tick samples.
DOI: 10.6084/m9.figshare.8196926
title: Additional file 7: of WhoGEM: an admixture-based prediction machine accurately predicts quantitative functional traits in plants

description: Code 1. R code for the ProvenancePredictor function (R (txt) (R 13 kb)
DOI: 10.6084/m9.figshare.8196923
title: MOESM3 of Surface sterilization methods impact measures of internal microbial diversity in ticks

description: Additional file 3: Table S2. OTU abundance without contaminants retrieved in tick-organ samples (guts and carcasses).
DOI: 10.6084/m9.figshare.8196926.v1
title: Additional file 7: of WhoGEM: an admixture-based prediction machine accurately predicts quantitative functional traits in plants

description: Code 1. R code for the ProvenancePredictor function (R (txt) (R 13 kb)
DOI: 10.6084/m9.figshare.8196929.v1
title: MOESM4 of Surface sterilization methods impact measures of internal microbial diversity in ticks

description: Additional file 4: Table S3. OTU abundance without contaminants and intracellular endosymbiont retrieved in cuticle smears, wash samples, and ethanol-treated whole-tick samples.
DOI: 10.6084/m9.figshare.8196932.v1
title: Additional file 8: of WhoGEM: an admixture-based prediction machine accurately predicts quantitative functional traits in plants

description: Code 2. R code for the ProvenancePredictor cross-validation function (R (txt) (R 13 kb)
DOI: 10.6084/m9.figshare.8196920
title: MOESM2 of Surface sterilization methods impact measures of internal microbial diversity in ticks

description: Additional file 2: Table S1. OTU abundance without contaminants retrieved in whole-tick samples.
DOI: 10.6084/m9.figshare.8196923.v1
title: MOESM3 of Surface sterilization methods impact measures of internal microbial diversity in ticks

description: Additional file 3: Table S2. OTU abundance without contaminants retrieved in tick-organ samples (guts and carcasses).
DOI: 10.6084/m9.figshare.8196920.v1
title: MOESM2 of Surface sterilization methods impact measures of internal microbial diversity in ticks

description: Additional file 2: Table S1. OTU abundance without contaminants retrieved in whole-tick samples.