cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.8091776
title: Kin terms in the Tuparian languages (Tupian family)

description: Abstract This article analyzes kinship terminology in the five languages of the Tupari branch of the Tupi family through two distinct approaches. First, the article compares kinship terms used in the Tupari languages and reconstructs ancestral Proto-Tupari forms for the main categories of consanguineous kin and in-laws. The five members of the Tupari branch possess clearly cognate terms which can be reconstructed for the proto-language of the family in various shared kinship configurations: grandparents (FF, FM, MF, MM), parents (M, F), aunts and uncles (MZ, MB, FZ), siblings (B, Z) and cousins (FBS, FBD), children (S, D), nieces and nephews (BS, BD, ZD, ZS), grandchildren (SS, SD, DS, DD), and affines (W, H, DH). Building upon the comparison of kinship terms within the contemporary Tupari languages and the ancestral forms reconstructed for Proto-Tuparí, these kinship systems are then discussed through the lens of anthropological theory, situating them within the theoretical developments in Amazonian kinship studies since 1990.
DOI: 10.6084/m9.figshare.8091782.v1
title: Chemical, ecotoxicological and genotoxicological evaluation of waters of open pit mine lakes

description: ABSTRACT Artificial lakes formed in open pit mining areas are complex units and constitute emerging environmental liabilities arising from the mining industry. Although they are increasing in number in several parts of the world, they still form a recent and little studied environmental problem, especially regarding the quality and toxicity of its waters, which may represent worrying environmental risks. This study describes the results of the seasonal analysis of chemical, ecotoxicological and genotoxicological aspects of the waters of three disused gold mining pit lakes located in Mara Rosa, Goiás, Brazil. Samples were collected in profile in two different climatic seasons, winter and summer, and were chemically analyzed to determine their load of metals and anions. Ecotoxicological Tests and Comet Assays were also developed with fish of the Danio rerio species. The results indicated that the concentrations of the chemical species analyzed were predominantly increased in the surface-bottom direction and higher during the dry season. Lago Azul waters have been shown to be chemically more compromised as they are acidic and rich in potentially toxic analytes such as aluminum, cadmium, lead, copper, manganese, nickel, and zinc. No significant ecotoxicological alterations were identified for any of the analyzed samples, although, in genotoxicological terms, Lago Azul presented DNA damage from concentrations of 25% in the dry season and 50% in the wet season.
DOI: 10.6084/m9.figshare.8091767
title: Familial aggregation and heritability of markers of metabolic risk, physical activity, and physical fitness in nuclear families from Muzambinho (Minas Gerais, Brazil)

description: ABSTRACT Objective This study investigated the familial aggregation and heritability of markers of metabolic risk, physical activity, and physical fitness in nuclear families from Muzambinho (Minas Gerais, Brazil). Subjects and methods The study included members of 139 families, comprising 97 fathers (aged 40 ± 7 years), 129 mothers (35 ± 6 years), 136 sons (12 ± 4 years), and 121 daughters (12 ± 5 years). Evaluated markers included (A) body mass index, waist circumference, glycemia, and cholesterolemia, as metabolic risk markers; (B) total weekly volume of physical activity, as a physical activity marker; and (C) relative muscle strength, as a physical fitness marker. Correlations between family members and heritability (h2) were estimated using the software S.A.G.E. Results Significant familial correlations were obtained between parents-offspring for glycemia and cholesterolemia (both ρ = 0.21, p &lt; 0.05) and relative muscle strength (ρ = 0.23, p &lt; 0.05), and between siblings for waist circumference, glycemia, total weekly volume of physical activity, and relative muscle strength (ρ variation 0.25 to 0.36, p &lt; 0.05). Heritability values were significant for almost all variables (h2 variations: 20% to 57% for metabolic risk markers, 22% for the total weekly volume of physical activity, and 50% for relative muscle strength), except for waist circumference (h2 = 15%, p = 0.059). Conclusion The presence of significant correlations between family members and/or significant heritability strengthens the possible genetic and/or common familial environment influence on metabolic risk markers, total weekly volume of physical activity, and relative muscle strength.
DOI: 10.6084/m9.figshare.8091773
title: Does having Turner syndrome affect quality of life in Brazilian women compared to common population?

description: ABSTRACT Objectives We aimed to measure the quality of life (QoL) of patients with Turner syndrome (PTS) and determine the extent to which their clinical or laboratory alterations influence QoL compared to reference women (RW) of the same age range. Subjects and methods From Dec-2013 to Dec-2014, 90 participants were recruited. They were 18 years and older: 48 with Turner syndrome (TS) (PTS) and 42 without (RW). Recruited subjects completed the Portuguese version of Short Form 36 (SF-36) questionnaire, and blood was drawn to measure LH, FSH, oestradiol (E2), progesterone (P4), SHBG, and SDHEA (by ECLIA) and testosterone (by LC MS/MS). Results Age and schooling were similar between groups. The most common occupations for PTS were health worker, administration and education, and health worker or cashier for RW. Most participants were Catholic or Evangelical. Eighty-one percent (39/48) of cases used Hormonal Replacement Therapy (HRT), mostly transdermal (23/39). RW and PTS scored similarly on the SF-36 questionnaire. RW had higher oestradiol (p = 0,01), lower FSH (p = 0,01) and higher testosterone (p = 0,01) than PTS. Concentrations of P4, LH, SHBG or SDHEA were similar. Significant associations were found among QoL and hormones (E2 with Vitality and LH with Physical Role) only in the PTS group. Conclusions PTS do not consider that TS affects their QoL as measured by domains on the SF-36. Oestradiol was related with QoL, emphasising the importance of HRT.
DOI: 10.6084/m9.figshare.8091776.v1
title: Kin terms in the Tuparian languages (Tupian family)

description: Abstract This article analyzes kinship terminology in the five languages of the Tupari branch of the Tupi family through two distinct approaches. First, the article compares kinship terms used in the Tupari languages and reconstructs ancestral Proto-Tupari forms for the main categories of consanguineous kin and in-laws. The five members of the Tupari branch possess clearly cognate terms which can be reconstructed for the proto-language of the family in various shared kinship configurations: grandparents (FF, FM, MF, MM), parents (M, F), aunts and uncles (MZ, MB, FZ), siblings (B, Z) and cousins (FBS, FBD), children (S, D), nieces and nephews (BS, BD, ZD, ZS), grandchildren (SS, SD, DS, DD), and affines (W, H, DH). Building upon the comparison of kinship terms within the contemporary Tupari languages and the ancestral forms reconstructed for Proto-Tuparí, these kinship systems are then discussed through the lens of anthropological theory, situating them within the theoretical developments in Amazonian kinship studies since 1990.
DOI: 10.6084/m9.figshare.8091773.v1
title: Does having Turner syndrome affect quality of life in Brazilian women compared to common population?

description: ABSTRACT Objectives We aimed to measure the quality of life (QoL) of patients with Turner syndrome (PTS) and determine the extent to which their clinical or laboratory alterations influence QoL compared to reference women (RW) of the same age range. Subjects and methods From Dec-2013 to Dec-2014, 90 participants were recruited. They were 18 years and older: 48 with Turner syndrome (TS) (PTS) and 42 without (RW). Recruited subjects completed the Portuguese version of Short Form 36 (SF-36) questionnaire, and blood was drawn to measure LH, FSH, oestradiol (E2), progesterone (P4), SHBG, and SDHEA (by ECLIA) and testosterone (by LC MS/MS). Results Age and schooling were similar between groups. The most common occupations for PTS were health worker, administration and education, and health worker or cashier for RW. Most participants were Catholic or Evangelical. Eighty-one percent (39/48) of cases used Hormonal Replacement Therapy (HRT), mostly transdermal (23/39). RW and PTS scored similarly on the SF-36 questionnaire. RW had higher oestradiol (p = 0,01), lower FSH (p = 0,01) and higher testosterone (p = 0,01) than PTS. Concentrations of P4, LH, SHBG or SDHEA were similar. Significant associations were found among QoL and hormones (E2 with Vitality and LH with Physical Role) only in the PTS group. Conclusions PTS do not consider that TS affects their QoL as measured by domains on the SF-36. Oestradiol was related with QoL, emphasising the importance of HRT.
DOI: 10.6084/m9.figshare.8091767.v1
title: Familial aggregation and heritability of markers of metabolic risk, physical activity, and physical fitness in nuclear families from Muzambinho (Minas Gerais, Brazil)

description: ABSTRACT Objective This study investigated the familial aggregation and heritability of markers of metabolic risk, physical activity, and physical fitness in nuclear families from Muzambinho (Minas Gerais, Brazil). Subjects and methods The study included members of 139 families, comprising 97 fathers (aged 40 ± 7 years), 129 mothers (35 ± 6 years), 136 sons (12 ± 4 years), and 121 daughters (12 ± 5 years). Evaluated markers included (A) body mass index, waist circumference, glycemia, and cholesterolemia, as metabolic risk markers; (B) total weekly volume of physical activity, as a physical activity marker; and (C) relative muscle strength, as a physical fitness marker. Correlations between family members and heritability (h2) were estimated using the software S.A.G.E. Results Significant familial correlations were obtained between parents-offspring for glycemia and cholesterolemia (both ρ = 0.21, p &lt; 0.05) and relative muscle strength (ρ = 0.23, p &lt; 0.05), and between siblings for waist circumference, glycemia, total weekly volume of physical activity, and relative muscle strength (ρ variation 0.25 to 0.36, p &lt; 0.05). Heritability values were significant for almost all variables (h2 variations: 20% to 57% for metabolic risk markers, 22% for the total weekly volume of physical activity, and 50% for relative muscle strength), except for waist circumference (h2 = 15%, p = 0.059). Conclusion The presence of significant correlations between family members and/or significant heritability strengthens the possible genetic and/or common familial environment influence on metabolic risk markers, total weekly volume of physical activity, and relative muscle strength.
DOI: 10.6084/m9.figshare.8091770
title: Searching for mutations in the HNF1B gene in a Brazilian cohort with renal cysts and hyperglycemia

description: ABSTRACT Objective To verify the presence of variants in HNF1B in a sample of the Brazilian population selected according to the presence of renal cysts associated with hyperglycemia. Subjects and methods We evaluated 28 unrelated patients with clinical suspicion of HNF1B mutation because of the concomitant presence of diabetes mellitus (DM) or prediabetes and renal cysts. Genotyping was accomplished using Sanger sequencing or multiplex ligation-dependent probe amplification (MLPA). In positive cases, available relatives were recruited. Results We found two patients with HNF1B mutations. The first presented the variant p.Pro328Leufs*48(c.983delC) and had DM, renal cysts, and hypomagnesemia. The second presented a heterozygous whole gene deletion in HNF1B, DM, renal cysts, body and tail pancreatic agenesis, and hypomagnesemia; this alteration was also found in his two siblings and his father. Conclusion The recruitment of suspected cases of HNF1B gene mutations in Brazilians due to hyperglycemia and renal cysts presents two positive cases. Our cases contribute to the annotation of clinical and biochemical phenotypes of this rare form of maturity-onset diabetes of the young (MODY).
DOI: 10.6084/m9.figshare.8091770.v1
title: Searching for mutations in the HNF1B gene in a Brazilian cohort with renal cysts and hyperglycemia

description: ABSTRACT Objective To verify the presence of variants in HNF1B in a sample of the Brazilian population selected according to the presence of renal cysts associated with hyperglycemia. Subjects and methods We evaluated 28 unrelated patients with clinical suspicion of HNF1B mutation because of the concomitant presence of diabetes mellitus (DM) or prediabetes and renal cysts. Genotyping was accomplished using Sanger sequencing or multiplex ligation-dependent probe amplification (MLPA). In positive cases, available relatives were recruited. Results We found two patients with HNF1B mutations. The first presented the variant p.Pro328Leufs*48(c.983delC) and had DM, renal cysts, and hypomagnesemia. The second presented a heterozygous whole gene deletion in HNF1B, DM, renal cysts, body and tail pancreatic agenesis, and hypomagnesemia; this alteration was also found in his two siblings and his father. Conclusion The recruitment of suspected cases of HNF1B gene mutations in Brazilians due to hyperglycemia and renal cysts presents two positive cases. Our cases contribute to the annotation of clinical and biochemical phenotypes of this rare form of maturity-onset diabetes of the young (MODY).
DOI: 10.6084/m9.figshare.8091755
title: Hypothyroid offspring replacement with euthyroid wet nurses during lactation improves thyroid programming without modifying metabolic programming

description: ABSTRACT Objective Determine the milk quality effect during lactation on the metabolic and thyroid programming of hypothyroid offspring. Materials and methods Ten-week-old female Wistar rats were divided into two groups: euthyroid and thyroidectomy-caused hypothyroidism. The rats were matted and, one day after birth, the pups were divided into three groups: euthyroid offspring (EO), hypothyroid offspring (HO) and hypothyroid with a euthyroid replacement wet nurse (HRO). During lactation, the milk quality and offspring body length were evaluated. The body weight and energy intake were determined on a weekly basis, as well as the metabolic profile at the prepubertal (P35-36) and postpubertal (P55-56) ages. At P56, the animals were sacrificed, the adipose tissues were weighed and the thyroid glands were dissected for histological processing. Results The milk of the hypothyroid wet nurse decreases proteins (16-26%), lipids (22-29%) and lactate (22-37%) with respect to euthyroid. The HO has a lower body weight gain (23-33%), length (11-13%) and energy intake (15-21%). In addition, HO presents impaired fasting glucose and dyslipidemia, as well as a reduction in seric thyroid hormone (18-34%), adipose reserves (26-68%) and thyroid gland weight (25-34%). The HO present thyroid gland cytoarchitecture alteration. The HRO develop the same metabolic alterations as the HO. However, the thyroid gland dysfunction was partially prevented because the HRO improved under about 10% of the serum thyroid hormone concentration, the thyroid gland weight although histological glandular changes presented. Conclusions The replacement of hypothyroid offspring with a euthyroid wet nurse during lactation can improve the thyroid programming without modifying metabolic programming.
DOI: 10.6084/m9.figshare.8091746
title: Papers_FeatureSelectionAlgorith.csv

description: This Database belongs to “A Database for Using Machine Learning and Data Mining Techniques for Coronary Artery Disease diagnosis” research paper. This database includes 15 tables. We chose to index papers related to CAD detection using machine learning and data mining approaches that are published between 1992 and 2018. These criteria result in 126 papers in which 490 authors contributed to these papers. These papers studied 68 different datasets with almost more than 360 distinct features collected in 18 countries from Asia, Europe, and America. In these papers, 140 different machine learning or data mining techniques were applied to diagnose CAD. To use csv file, open it in excel or import it in your database.
DOI: 10.6084/m9.figshare.8091755.v1
title: Hypothyroid offspring replacement with euthyroid wet nurses during lactation improves thyroid programming without modifying metabolic programming

description: ABSTRACT Objective Determine the milk quality effect during lactation on the metabolic and thyroid programming of hypothyroid offspring. Materials and methods Ten-week-old female Wistar rats were divided into two groups: euthyroid and thyroidectomy-caused hypothyroidism. The rats were matted and, one day after birth, the pups were divided into three groups: euthyroid offspring (EO), hypothyroid offspring (HO) and hypothyroid with a euthyroid replacement wet nurse (HRO). During lactation, the milk quality and offspring body length were evaluated. The body weight and energy intake were determined on a weekly basis, as well as the metabolic profile at the prepubertal (P35-36) and postpubertal (P55-56) ages. At P56, the animals were sacrificed, the adipose tissues were weighed and the thyroid glands were dissected for histological processing. Results The milk of the hypothyroid wet nurse decreases proteins (16-26%), lipids (22-29%) and lactate (22-37%) with respect to euthyroid. The HO has a lower body weight gain (23-33%), length (11-13%) and energy intake (15-21%). In addition, HO presents impaired fasting glucose and dyslipidemia, as well as a reduction in seric thyroid hormone (18-34%), adipose reserves (26-68%) and thyroid gland weight (25-34%). The HO present thyroid gland cytoarchitecture alteration. The HRO develop the same metabolic alterations as the HO. However, the thyroid gland dysfunction was partially prevented because the HRO improved under about 10% of the serum thyroid hormone concentration, the thyroid gland weight although histological glandular changes presented. Conclusions The replacement of hypothyroid offspring with a euthyroid wet nurse during lactation can improve the thyroid programming without modifying metabolic programming.
DOI: 10.6084/m9.figshare.8091740
title: An update on the tools for creating transgenic animal models of human diseases – focus on atherosclerosis

description: Animal models of diseases are invaluable tools of modern medicine. More than forty years have passed since the first successful experiments and the spectrum of available models, as well as the list of methods for creating them, have expanded dramatically. The major step forward in creating specific disease models was the development of gene editing techniques, which allowed for targeted modification of the animal's genome. In this review, we discuss the available tools for creating transgenic animal models, such as transgenesis methods, recombinases, and nucleases, including zinc finger nuclease (ZFN), transcription activator-like effector nuclease (TALEN), and CRISPR/Cas9 systems. We then focus specifically on the models of atherosclerosis, especially mouse models that greatly contributed to improving our understanding of the disease pathogenesis and we outline their characteristics and limitations.
DOI: 10.6084/m9.figshare.8091737
title: Estimates of reference evapotranspiration in the municipality of Ariquemes (RO) using neural networks GMDH-type

description: ABSTRACT Reference evapotranspiration is a climatological variable of great importance for water use dimensioning in irrigation methods. In order to contribute to the climatic understanding of Ariquemes, Rodônia state, Brazil, the study aims to model the behavior of the time series of reference evapotranspiration using a GMDH-type (Group Method of Data Handling) artificial neural network (ANN) and to compare it with the SARIMA (Seasonal Autoregressive Integrated Moving Average) methodology. Data from the National Institute of Meteorology - INMET, obtained at the Automatic Weather Station of Ariquemes, from January 2011 to January 2014, were used. Data analysis was performed using software R version 3.3.1 through the GMDH-type ANN package. Modeling by GMDH-type ANN led to results similar to the results of the SARIMA model, thus constituting an option to predict climatic time series. GMDH-type models with larger numbers of inputs and layers presented lowest mean square error.
DOI: 10.6084/m9.figshare.8091740.v1
title: An update on the tools for creating transgenic animal models of human diseases – focus on atherosclerosis

description: Animal models of diseases are invaluable tools of modern medicine. More than forty years have passed since the first successful experiments and the spectrum of available models, as well as the list of methods for creating them, have expanded dramatically. The major step forward in creating specific disease models was the development of gene editing techniques, which allowed for targeted modification of the animal's genome. In this review, we discuss the available tools for creating transgenic animal models, such as transgenesis methods, recombinases, and nucleases, including zinc finger nuclease (ZFN), transcription activator-like effector nuclease (TALEN), and CRISPR/Cas9 systems. We then focus specifically on the models of atherosclerosis, especially mouse models that greatly contributed to improving our understanding of the disease pathogenesis and we outline their characteristics and limitations.
DOI: 10.6084/m9.figshare.8091734
title: Analysis of the scientific production on the evaluation of oral health policies in Brazil

description: ABSTRACT With the aim of analyzing the scientific production on the evaluation of oral health public policies in Brazil, a bibliometric study of publications between January 1980 and May 2015was conducted, using the SciELO and BVS/Bireme/Paho databases. Forty five papers in Portuguese and/or English were included, and those in duplicate and out of the subject scope were excluded. The classification was carried out by two researchers regarding design/study strategy, the main findings and characteristics of the evaluative study according to the attributes of research in the field. The articles were published between 2002 and 2015. The Southeastern region (48.9%) and public institutions (82.2%) account for the highest production. The highest concentration of articles was in Qualis A2 journals (48.9%). Most of the studies (86.6%) were quantitative and the largest proportion was about coverage and utilization (22.2%) and monitoring of health interventions (20%). The studies’ main characteristic was the availability and social distribution of resources (64.4%). The production in the field has been published in relevant journals in collective health, which confers its importance for understanding the dynamics of care delivery, as a critical analysis and a way of pointing out successful experiences and directions to be corrected in the policies, as recommended in the oral health conferences.
DOI: 10.6084/m9.figshare.8091731
title: Lack of institutional work and organizational change failure in Brazilian local governments

description: Abstract This article proposes a theoretical framework to explain the failure of the compulsory adoption of new practices in the financial management cycle in local governments. The empirical analysis applies the framework to the control systems implementation in Brazilian municipalities. The findings of a qualitative comparative analysis applied to seven local governments show that despite human capabilities and information systems being a necessary condition, they are insufficient to deeply implement such internal control practices. Institutional capital is a condition sine qua non for the adoption of new practices on financial management and control in Brazilian local governments. The adoption of such reforms depends on an active network of powerful actors involved in institutional work supporting the changes.