cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.3442787.v1
title: Supplementary Material for: Bovine Mammary Nutrigenomics and Changes in the Milk Composition due to Rapeseed or Sunflower Oil Supplementation of High-Forage or High-Concentrate Diets

description: <b><i>Background:</i></b> Fatty acid (FA) composition plays a crucial role in milk nutritional quality. Despite the known nutritional regulation of ruminant milk composition, the overall mammary mechanisms underlying this regulation are far from being understood. The aim of our study was to determine nutritional regulation of mammary transcriptomes in relation to the cow milk composition. <b><i>Methods:</i></b> Twelve cows received diets differing in the forage-to-concentrate ratio [high forage (HF) and low forage (LF)] supplemented or not with lipids [HF with whole intact rapeseeds (RS) and LF sunflower oil (SO)] in a 4 × 4 Latin square design. Milk production and FA composition were determined. The gene expression profile was studied using RT-qPCR and a bovine microarray. <b><i>Results:</i></b> Our results showed a higher amplitude of milk composition and mammary transcriptome responses to lipid supplementation with the LF-SO compared with the LF diet than with the HF-RS compared with the HF diet. Forty-nine differentially expressed genes, including genes involved in lipid metabolism, were identified with LF-SO versus LF, whereas RS supplementation to the HF diet did not affect the mammary transcriptome. <b><i>Conclusions:</i></b> This study highlights different responses to lipid supplementation of milk production and composition and mammary transcriptomes depending on the nature of lipid supplementation and the percentage of dietary concentrate.
DOI: 10.6084/m9.figshare.3442778
title: Supplementary Material for: FAM222B Is Not a Likely Novel Candidate Gene for Cerebral Cavernous Malformations

description: Cerebral cavernous malformations (CCMs) are prevalent slow-flow vascular lesions which harbour the risk to develop intracranial haemorrhages, focal neurological deficits, and epileptic seizures. Autosomal dominantly inherited CCMs were found to be associated with heterozygous inactivating mutations in 3 genes, <i>CCM1</i><i>(KRIT1)</i>, <i>CCM2</i><i>(MGC4607)</i>, and <i>CCM3</i><i>(PDCD10)</i> in 1999, 2003 and 2005, respectively. Despite the availability of high-throughput sequencing techniques, no further <i>CCM</i> gene has been published since. Here, we report on the identification of an autosomal dominantly inherited frameshift mutation in a gene of thus far unknown function, <i>FAM222B</i><i>(C17orf63)</i>, through exome sequencing of CCM patients mutation-negative for <i>CCM1-3</i>. A yeast 2-hybrid screen revealed interactions of FAM222B with the tubulin cytoskeleton and STAMBP which is known to be associated with microcephaly-capillary malformation syndrome. However, a phenotype similar to existing models was not found, neither in <i>fam222bb</i>/<i>fam222ba</i> double mutant zebrafish generated by transcription activator-like effector nucleases nor in an in vitro sprouting assay using human umbilical vein endothelial cells transfected with siRNA against <i>FAM222B</i>. These observations led to the assumption that aberrant <i>FAM222B</i> is not involved in the formation of CCMs.
DOI: 10.6084/m9.figshare.3442778.v1
title: Supplementary Material for: FAM222B Is Not a Likely Novel Candidate Gene for Cerebral Cavernous Malformations

description: Cerebral cavernous malformations (CCMs) are prevalent slow-flow vascular lesions which harbour the risk to develop intracranial haemorrhages, focal neurological deficits, and epileptic seizures. Autosomal dominantly inherited CCMs were found to be associated with heterozygous inactivating mutations in 3 genes, <i>CCM1</i><i>(KRIT1)</i>, <i>CCM2</i><i>(MGC4607)</i>, and <i>CCM3</i><i>(PDCD10)</i> in 1999, 2003 and 2005, respectively. Despite the availability of high-throughput sequencing techniques, no further <i>CCM</i> gene has been published since. Here, we report on the identification of an autosomal dominantly inherited frameshift mutation in a gene of thus far unknown function, <i>FAM222B</i><i>(C17orf63)</i>, through exome sequencing of CCM patients mutation-negative for <i>CCM1-3</i>. A yeast 2-hybrid screen revealed interactions of FAM222B with the tubulin cytoskeleton and STAMBP which is known to be associated with microcephaly-capillary malformation syndrome. However, a phenotype similar to existing models was not found, neither in <i>fam222bb</i>/<i>fam222ba</i> double mutant zebrafish generated by transcription activator-like effector nucleases nor in an in vitro sprouting assay using human umbilical vein endothelial cells transfected with siRNA against <i>FAM222B</i>. These observations led to the assumption that aberrant <i>FAM222B</i> is not involved in the formation of CCMs.
DOI: 10.6084/m9.figshare.3439880
title: Isotopic composition in precipitation and groundwater in the northern mountainous region of the Central Valley of Costa Rica

description: The linkage between precipitation and recharge is still poorly understood in the Central America region. This study focuses on stable isotopic composition in precipitation and groundwater in the northern mountainous region of the Central Valley of Costa Rica. During the dry season, rainfall samples corresponded to enriched events with high deuterium excess. By mid-May, the Intertropical Convergence Zone poses over Costa Rica resulting in a depletion of <sup>18</sup>O/<sup>16</sup>O and <sup>2</sup>H/H ratios. A parsimonious four-variable regression model (<i>r</i><sup>2 </sup>= 0.52) was able to predict daily δ<sup>18</sup>O in precipitation. Air mass back trajectories indicated a combination of Caribbean Sea and Pacific Ocean sources, which is clearly depicted in groundwater isoscape. Aquifers relying on Pacific-originated recharge exhibited a more depleted pattern, whereas recharge areas relying on Caribbean parental moisture showed an enrichment trend. These results can be used to enhance modelling efforts in Central America where scarcity of long-term data limits water resources management plans.
DOI: 10.6084/m9.figshare.3439880.v1
title: Isotopic composition in precipitation and groundwater in the northern mountainous region of the Central Valley of Costa Rica

description: The linkage between precipitation and recharge is still poorly understood in the Central America region. This study focuses on stable isotopic composition in precipitation and groundwater in the northern mountainous region of the Central Valley of Costa Rica. During the dry season, rainfall samples corresponded to enriched events with high deuterium excess. By mid-May, the Intertropical Convergence Zone poses over Costa Rica resulting in a depletion of <sup>18</sup>O/<sup>16</sup>O and <sup>2</sup>H/H ratios. A parsimonious four-variable regression model (<i>r</i><sup>2 </sup>= 0.52) was able to predict daily δ<sup>18</sup>O in precipitation. Air mass back trajectories indicated a combination of Caribbean Sea and Pacific Ocean sources, which is clearly depicted in groundwater isoscape. Aquifers relying on Pacific-originated recharge exhibited a more depleted pattern, whereas recharge areas relying on Caribbean parental moisture showed an enrichment trend. These results can be used to enhance modelling efforts in Central America where scarcity of long-term data limits water resources management plans.
DOI: 10.6084/m9.figshare.3439871
title: The contribution of trees and palms to a balanced diet in three rural villages of the Fatick Province, Senegal

description: Improving the quality of people’s diets represents a major challenge for developing countries, particularly in Sahelian African countries. Foods from trees, shrubs, and palms are present in many meals and may improve dietary quality, especially for rural communities but, as their contributions have rarely been quantified, investigating the link between the intake of tree foods and the nutritional composition of diet is important. This study assesses the contribution of tree and palm foods to dietary intake in three rural communities in Senegal, using three household food consumption surveys to quantify the dietary intake of meals. The consumption of tree and palm foods in meals was frequent, mentioned by 93–99% of the families depending on the time of year. Products of 11 tree and palm species were used in meals, with <i>Adansonia digitata</i> (baobab) leaves the most frequently mentioned. The energy contribution of tree and palm foods was low, but their contribution of certain micronutrients was high, with 56% of the daily household food consumption of vitamin A, 45% of vitamin C, 17% of vitamin B6 and 21% of iron (Fe). Products from 18 tree and palm species were consumed as snacks or beverages between meals, and consumption was frequent in February and June, but rare in October. We discuss the possibilities of improving nutrition in rural communities from an increased use of trees and palms.
DOI: 10.6084/m9.figshare.3439871.v1
title: The contribution of trees and palms to a balanced diet in three rural villages of the Fatick Province, Senegal

description: Improving the quality of people’s diets represents a major challenge for developing countries, particularly in Sahelian African countries. Foods from trees, shrubs, and palms are present in many meals and may improve dietary quality, especially for rural communities but, as their contributions have rarely been quantified, investigating the link between the intake of tree foods and the nutritional composition of diet is important. This study assesses the contribution of tree and palm foods to dietary intake in three rural communities in Senegal, using three household food consumption surveys to quantify the dietary intake of meals. The consumption of tree and palm foods in meals was frequent, mentioned by 93–99% of the families depending on the time of year. Products of 11 tree and palm species were used in meals, with <i>Adansonia digitata</i> (baobab) leaves the most frequently mentioned. The energy contribution of tree and palm foods was low, but their contribution of certain micronutrients was high, with 56% of the daily household food consumption of vitamin A, 45% of vitamin C, 17% of vitamin B6 and 21% of iron (Fe). Products from 18 tree and palm species were consumed as snacks or beverages between meals, and consumption was frequent in February and June, but rare in October. We discuss the possibilities of improving nutrition in rural communities from an increased use of trees and palms.
DOI: 10.6084/m9.figshare.3439814
title: Salaried Strata Investment Behavior towards Financial Products-Review and Prospects for Future Research

description: The financial surface of the globe at all times reveals a weird balanced impact of the public investment preferences, their understanding about the investment requirements, their anticipation of returns on their investments etc. Perhaps forecasting the growth of the business world would be crucial without an apposite comprehension of the investment behavior of the key part of the society called salaried class. This paper covers appraisal of various financial instruments like equity/stocks, term deposits in banks, kisan vikas patra, national savings certificate, insurance policies, mutual fund and converse the factors persuading investment decision process. The major factors influencing the financial investment behavior are demographic factors (like age, income, qualification, gender, etc.) and socio-economic factors (like family income, tax benefits, safety of fund, risk inclination, return on investment). This study aims to serve a channel to the need of a comprehension of the financial objectives of the salaried class investors with that of their determined desire for the investment returns. Certainly, this information could unwrap the prospect of predicting even the future of Indian Economy itself besides, providing span to fine-tuning the investment prudence of the public towards progressive and fruitful choices for themselves and the nation.
DOI: 10.6084/m9.figshare.3439814.v2
title: Salaried Strata Investment Behavior towards Financial Products-Review and Prospects for Future Research

description: The financial surface of the globe at all times reveals a weird balanced impact of the public investment preferences, their understanding about the investment requirements, their anticipation of returns on their investments etc. Perhaps forecasting the growth of the business world would be crucial without an apposite comprehension of the investment behavior of the key part of the society called salaried class. This paper covers appraisal of various financial instruments like equity/stocks, term deposits in banks, kisan vikas patra, national savings certificate, insurance policies, mutual fund and converse the factors persuading investment decision process. The major factors influencing the financial investment behavior are demographic factors (like age, income, qualification, gender, etc.) and socio-economic factors (like family income, tax benefits, safety of fund, risk inclination, return on investment). This study aims to serve a channel to the need of a comprehension of the financial objectives of the salaried class investors with that of their determined desire for the investment returns. Certainly, this information could unwrap the prospect of predicting even the future of Indian Economy itself besides, providing span to fine-tuning the investment prudence of the public towards progressive and fruitful choices for themselves and the nation.
DOI: 10.6084/m9.figshare.3439793
title: BSaladin_Poster_Evolution.pdf

description: Fossils matter: improved estimates of divergence times in Pinus reveal older diversification.
DOI: 10.6084/m9.figshare.3439793.v1
title: BSaladin_Poster_Evolution.pdf

description: Fossils matter: improved estimates of divergence times in Pinus reveal older diversification.
DOI: 10.6084/m9.figshare.3439778
title: Common pathway signature in lung and liver fibrosis

description: Fibrosis, a progressive accumulation of extracellular matrix components, encompasses a wide spectrum of distinct organs, and accounts for an increasing burden of morbidity and mortality worldwide. Despite the tremendous clinical impact, the mechanisms governing the fibrotic process are not yet understood, and to date, no clinically reliable therapies for fibrosis have been discovered. Here we applied Regeneration Intelligence, a new bioinformatics software suite for qualitative analysis of intracellular signaling pathway activation using transcriptomic data, to assess a network of molecular signaling in lung and liver fibrosis. In both tissues, our analysis detected major conserved signaling pathways strongly associated with fibrosis, suggesting that some of the pathways identified by our algorithm but not yet wet-lab validated as fibrogenesis related, may be attractive targets for future research. While the majority of significantly disrupted pathways were specific to histologically distinct organs, several pathways have been concurrently activated or downregulated among the hepatic and pulmonary fibrosis samples, providing new evidence of evolutionary conserved pathways that may be relevant as possible therapeutic targets. While future confirmatory studies are warranted to validate these observations, our platform proposes a promising new approach for detecting fibrosis-promoting pathways and tailoring the right therapy to prevent fibrogenesis.
DOI: 10.6084/m9.figshare.3439778.v1
title: Common pathway signature in lung and liver fibrosis

description: Fibrosis, a progressive accumulation of extracellular matrix components, encompasses a wide spectrum of distinct organs, and accounts for an increasing burden of morbidity and mortality worldwide. Despite the tremendous clinical impact, the mechanisms governing the fibrotic process are not yet understood, and to date, no clinically reliable therapies for fibrosis have been discovered. Here we applied Regeneration Intelligence, a new bioinformatics software suite for qualitative analysis of intracellular signaling pathway activation using transcriptomic data, to assess a network of molecular signaling in lung and liver fibrosis. In both tissues, our analysis detected major conserved signaling pathways strongly associated with fibrosis, suggesting that some of the pathways identified by our algorithm but not yet wet-lab validated as fibrogenesis related, may be attractive targets for future research. While the majority of significantly disrupted pathways were specific to histologically distinct organs, several pathways have been concurrently activated or downregulated among the hepatic and pulmonary fibrosis samples, providing new evidence of evolutionary conserved pathways that may be relevant as possible therapeutic targets. While future confirmatory studies are warranted to validate these observations, our platform proposes a promising new approach for detecting fibrosis-promoting pathways and tailoring the right therapy to prevent fibrogenesis.
DOI: 10.6084/m9.figshare.3439757
title: Real-world treatment patterns and associated progression-free survival in relapsed/refractory multiple myeloma among US community oncology practices

description: <b>Background</b>: Evidence supporting optimal treatment sequencing in relapsed/refractory multiple myeloma (RRMM) patients requiring multiple therapy lines is lacking. <b>Methods</b>: Using retrospective chart data, this study describes real-world RRMM treatment patterns and related progression-free survival (PFS) in US community oncology clinics. <b>Results</b>: Bortezomib ± a non-immunomodulatory drug (IMiD), lenalidomide ± a non-proteasome inhibitor (PI), bortezomib + an IMiD were the most commonly used regimens in early lines of therapy. Median PFS was similar in 1<sup>st</sup> (11.1 months) and 2<sup>nd</sup> line (10.5) and decreased in lines 3 through 5 (3<sup>rd</sup>: 7.9; 4<sup>th</sup>: 7.2, 5<sup>th</sup>: 5.4). Longest PFS (12.5 months) in first line was with bortezomib + ImiD; longest PFS in second line was with lenalidomide ± a non-PI was (13.2 months). <b>Conclusions</b>: Re-treatment with bortezomib was common; novel agents were reserved for later therapy lines. Overall, the observed PFS associated with real-world treatment sequences were shorter than those reported in clinical trials.
DOI: 10.6084/m9.figshare.3439757.v1
title: Real-world treatment patterns and associated progression-free survival in relapsed/refractory multiple myeloma among US community oncology practices

description: <b>Background</b>: Evidence supporting optimal treatment sequencing in relapsed/refractory multiple myeloma (RRMM) patients requiring multiple therapy lines is lacking. <b>Methods</b>: Using retrospective chart data, this study describes real-world RRMM treatment patterns and related progression-free survival (PFS) in US community oncology clinics. <b>Results</b>: Bortezomib ± a non-immunomodulatory drug (IMiD), lenalidomide ± a non-proteasome inhibitor (PI), bortezomib + an IMiD were the most commonly used regimens in early lines of therapy. Median PFS was similar in 1<sup>st</sup> (11.1 months) and 2<sup>nd</sup> line (10.5) and decreased in lines 3 through 5 (3<sup>rd</sup>: 7.9; 4<sup>th</sup>: 7.2, 5<sup>th</sup>: 5.4). Longest PFS (12.5 months) in first line was with bortezomib + ImiD; longest PFS in second line was with lenalidomide ± a non-PI was (13.2 months). <b>Conclusions</b>: Re-treatment with bortezomib was common; novel agents were reserved for later therapy lines. Overall, the observed PFS associated with real-world treatment sequences were shorter than those reported in clinical trials.
DOI: 10.6084/m9.figshare.3439706
title: Stress coping skills in adolescent high school students / Afrontamiento del estrés en adolescentes estudiantes de nivel medio superior

description: La adolescencia supone una reorganización de las interacciones sociales, interpersonales (Ávila, Heredia, Gómez y Martínez, 2006; Cardozo y Alderete 2009), lo que genera estrés (Frydenberg y Lewis, 2000). Para afrontarla, se emplea un conjunto de acciones y cogniciones que capacitan para tolerar o minimizar los efectos producidos (González, Montoya, Martina y Bernabéu, 2002). El propósito de la investigación es describir las estrategias de afrontamiento que emplean los adolescentes estudiantes del nivel medio superior, realizando comparaciones por género y edad. Se trabajó con 724 adolescentes, 413 mujeres y 311 hombres, con un rango de edad entre 14 a 17 años, del Valle de Toluca, Estado de México. Se aplicó la Escala de Afrontamiento para Adolescentes (ACS), elaborada por Frydenberg y Lewis (2000). Los resultados obtenidos de las estrategias que emplean los adolescentes ante situaciones estresantes son: esforzarse y tener éxito, buscar diversiones relajantes y preocuparse. Las mujeres emplean más estrategias centradas en resolver el problema e intervienen sus emociones, a diferencia de los hombres que evaden el problema y son más reservados emocionalmente. Con respecto a la comparación por edad, se encontró que los de 16 años emplean estrategias de evasión del problema. Se discuten las implicancias del estudio.<br><b>AUTOR: </b><b>Morales Salinas,Brenda Guadalupe</b>; <b>Moysén Chimal,Alejandra</b><b>EDITORIAL: </b><b>UniversidadPeruana de Ciencias Aplicadas (UPC)</b><b>REVISTA: </b><b>Revista Digital deInvestigación en Docencia Universitaria (RIDU)</b><b>FECHA DE PUBLICACIÓN: </b>jun-2015<b>URL: </b>http://hdl.handle.net/10757/604869<b>DOI: </b>10.19083/ridu.9.380<br><b>ENLACES ADICIONALES: </b>http://revistas.upc.edu.pe/index.php/docencia/article/view/380<b>PDF: </b>TEXTO COMPLETO / FULL TEXT
DOI: 10.6084/m9.figshare.3439589
title: Helminths of 13 species of microhylid frogs (Anura: Microhylidae) from Papua New Guinea

description: In an attempt to better document the invertebrate biodiversity of the threatened fauna of Papua New Guinea (PNG), 208 microhylid frogs representing 13 species collected in 2009 and 2010 in PNG were examined for endoparasitic helminths. This study found mature individuals of one species of Digenea (<i>Opisthioglyphe cophixali</i>), adults of two species of Cestoda (<i>Nematotaenia hylae, Cylindrotaenia</i> sp.) and cysticerci of an unidentified cestode species; adults of nine species of Nematoda (<i>Aplectana krausi</i>, <i>Bakeria bakeri</i>, <i>Cosmocerca novaeguineae</i>, <i>Cosmocercella phrynomantisi</i>, <i>Falcaustra papuensis</i>, <i>Icosiella papuensis</i>, <i>Ochtoterenella papuensis</i>, <i>Parathelandros allisoni</i>, <i>Parathelandros andersoni</i>), and one species of Acanthocephala (cystacanths in the family Centrorhynchidae). There was a high degree of endemism among the helminth species infecting the microhylids, with 83% of the species known only from PNG. Yet the helminth fauna infecting Papuan microhylids are generalists with direct life cycles (no intermediate host) that also infect other anuran species. We thus conclude infection is more dependent upon habitat conditions than diet. Twenty-nine new host records are reported.