cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.19360955.v3
title: COVID-19 and Placement Impact on College Students

description: The research goal was to investigate the impact of mindfulness-based training on stress and self-esteem of college students involved in placements. One hundred college students participating in campus placements were selected using purposive sampling from a Amrita School of Engineering, Coimbatore, India. College students were administered with Perceived Stress Scale, Rosenberg Self-Esteem Scale, and Kuppuswamy Socio-Economic Scale.
DOI: 10.6084/m9.figshare.19901702.v1
title: Dextran Sulfate/Pramlintide Polyelectrolyte Nanoparticles as a Promising Delivery System: Optimization, Evaluation of Supramolecular Interactions and Effect on Conformational Stability of the Peptide Drug

description: In this study, we investigated the feasibility to obtain nanoparticles (NPs) by assembling pramlintide (Pram) with dextran sulfate (DexS), as a new approach for mucosal peptide delivery. DexS/Pram NPs were prepared by dropwise addition of a Pram solution to a DexS solution under magnetic stirring. The physicochemical characteristics of NPs and molecular interactions involved in the co-assembling were evaluated by dynamic light scattering (DLS), transmission electronic microscopy (TEM), isothermal titration microcalorimetry, Fourier-transform infrared spectroscopy (FTIR), fluorescence quenching, and circular dichroism (CD). DexS/Pram NPs displayed a narrow size distribution (ca. 200 nm), negative zeta potential (ca. −40 mV), association efficiency close to 100%, and nanogel behavior. The assembling with DexS increased the Pram α-helical content, stabilizing the peptide in its bioactive form. The colloidal stability of nanoparticles was dependent on the salt concentration and it could be assumed that peptide release from nanoparticles occurs by dissociation of the complex at physiological conditions.
DOI: 10.6084/m9.figshare.19901702
title: Dextran Sulfate/Pramlintide Polyelectrolyte Nanoparticles as a Promising Delivery System: Optimization, Evaluation of Supramolecular Interactions and Effect on Conformational Stability of the Peptide Drug

description: In this study, we investigated the feasibility to obtain nanoparticles (NPs) by assembling pramlintide (Pram) with dextran sulfate (DexS), as a new approach for mucosal peptide delivery. DexS/Pram NPs were prepared by dropwise addition of a Pram solution to a DexS solution under magnetic stirring. The physicochemical characteristics of NPs and molecular interactions involved in the co-assembling were evaluated by dynamic light scattering (DLS), transmission electronic microscopy (TEM), isothermal titration microcalorimetry, Fourier-transform infrared spectroscopy (FTIR), fluorescence quenching, and circular dichroism (CD). DexS/Pram NPs displayed a narrow size distribution (ca. 200 nm), negative zeta potential (ca. −40 mV), association efficiency close to 100%, and nanogel behavior. The assembling with DexS increased the Pram α-helical content, stabilizing the peptide in its bioactive form. The colloidal stability of nanoparticles was dependent on the salt concentration and it could be assumed that peptide release from nanoparticles occurs by dissociation of the complex at physiological conditions.
DOI: 10.6084/m9.figshare.19901700
title: DEVELOPMENT IN GLYCOSYLATION METHODS: A KEY TO ACCESS ITS APPLICATIONS IN THE SYNTHESIS OF BIOACTIVE MOLECULES.

description: Glycosylation reaction is an important class of reactions in organic chemistry, and the development of the method contributes to the synthesis of many biologically active compounds containing various glycoside bonds. Is arguably the most important, albeit challenging, reaction in the field of carbohydrate chemistry. Examples of the products of glycosylation reactions are glycoproteins, glycolipids, glycosaminoglycans, oligosaccharides, and polysaccharides. Glycosylation types are classified according to the identity of the atom which binds the carbohydrate chain, i.e. C-linked, N-linked, O-linked or S-linked. In this short review, recent reports of the main glycosylation methods, basic mechanisms, factors influencing the stereoselectivity and their applications in the synthesis of bioactive molecules are described.
DOI: 10.6084/m9.figshare.19901700.v1
title: DEVELOPMENT IN GLYCOSYLATION METHODS: A KEY TO ACCESS ITS APPLICATIONS IN THE SYNTHESIS OF BIOACTIVE MOLECULES.

description: Glycosylation reaction is an important class of reactions in organic chemistry, and the development of the method contributes to the synthesis of many biologically active compounds containing various glycoside bonds. Is arguably the most important, albeit challenging, reaction in the field of carbohydrate chemistry. Examples of the products of glycosylation reactions are glycoproteins, glycolipids, glycosaminoglycans, oligosaccharides, and polysaccharides. Glycosylation types are classified according to the identity of the atom which binds the carbohydrate chain, i.e. C-linked, N-linked, O-linked or S-linked. In this short review, recent reports of the main glycosylation methods, basic mechanisms, factors influencing the stereoselectivity and their applications in the synthesis of bioactive molecules are described.
DOI: 10.6084/m9.figshare.19901741
title: Agro-Industrial Waste Valorization: Transformation of Starch from Mango Kernel into Biocompatible, Thermoresponsive and High Swelling Nanogels

description: Mango industry processing disposes 40-60% of this fruit as residues, such as peels and kernels. The exploration of bioproducts from these industrial rejects can reduce environmental impact besides of producing high value-added materials. In this scenario, carboxymethyl starch nanoparticles were produced from mango (Mangifera indica L.) kernel starch. These nanoparticles were then decorated with thermoresponsive chains of the amino terminated poly(N-isopropylacrylamide) (PNIPAM-NH2), with the intention of evaluating their applicability in the biomedical area. Elemental analysis, Fourier transform infrared (FTIR) and 1H nuclear magnetic resonance (NMR) spectroscopy confirmed successful grafting of PNIPAM-NH2 onto the carboxymethyl starch backbone. Scanning electron microscopy (SEM) images and dynamic light scattering (DLS) data showed sizes of 100 and 112 nm in the dry state and of 744 and 598 nm in the hydrated state, when the grafting degree (GD) was of 6 and 14.3%, respectively. The degree of swelling was of 41,100 and 15,100% for GD of 6 and 14.3% respectively, suggesting that the nanogels are suitable for drug incorporation. The toxicity of the nanogels to human adipose-derived stem cells (ADSCs) and red blood cells (RBCs) was evaluated by lactate dehydrogenase (LDH), alamarBlue and hemolysis assays. Both nanogels were non-cytotoxic and non-hemolytic, suggesting the suitability of these biomaterials for cell-and blood-contacting applications.
DOI: 10.6084/m9.figshare.19901741.v1
title: Agro-Industrial Waste Valorization: Transformation of Starch from Mango Kernel into Biocompatible, Thermoresponsive and High Swelling Nanogels

description: Mango industry processing disposes 40-60% of this fruit as residues, such as peels and kernels. The exploration of bioproducts from these industrial rejects can reduce environmental impact besides of producing high value-added materials. In this scenario, carboxymethyl starch nanoparticles were produced from mango (Mangifera indica L.) kernel starch. These nanoparticles were then decorated with thermoresponsive chains of the amino terminated poly(N-isopropylacrylamide) (PNIPAM-NH2), with the intention of evaluating their applicability in the biomedical area. Elemental analysis, Fourier transform infrared (FTIR) and 1H nuclear magnetic resonance (NMR) spectroscopy confirmed successful grafting of PNIPAM-NH2 onto the carboxymethyl starch backbone. Scanning electron microscopy (SEM) images and dynamic light scattering (DLS) data showed sizes of 100 and 112 nm in the dry state and of 744 and 598 nm in the hydrated state, when the grafting degree (GD) was of 6 and 14.3%, respectively. The degree of swelling was of 41,100 and 15,100% for GD of 6 and 14.3% respectively, suggesting that the nanogels are suitable for drug incorporation. The toxicity of the nanogels to human adipose-derived stem cells (ADSCs) and red blood cells (RBCs) was evaluated by lactate dehydrogenase (LDH), alamarBlue and hemolysis assays. Both nanogels were non-cytotoxic and non-hemolytic, suggesting the suitability of these biomaterials for cell-and blood-contacting applications.
DOI: 10.6084/m9.figshare.19901747
title: Inflammation and kidney involvement in human viral diseases caused by SARS-CoV-2, HIV, HCV and HBV

description: Abstract Inflammation is closely related to renal diseases. This is particularly true for renal diseases caused by infections as in viral diseases. In this review, we highlight the inflammatory mechanisms that underlie kidney dysfunction in SARS-CoV-2, human immunodeficiency (HIV), hepatitis C (HCV), and hepatitis B (HBV) infections. The pathophysiology of renal involvement in COVID-19 is complex, but kidney damage is frequent, and the prognosis is worse when it happens. Virus-like particles were demonstrated mostly in renal tubular epithelial cells and podocytes, which suggest that SARS-CoV-2 directly affects the kidneys. SARS-CoV-2 uses the angiotensin-converting enzyme 2 receptor, which is found in endothelial cells, to infect the human host cells. Critical patients with SARS-CoV-2-associated acute kidney injury (AKI) show an increase in inflammatory cytokines (IL-1β, IL-8, IFN-γ, TNF-α), known as cytokine storm that favors renal dysfunction by causing intrarenal inflammation, increased vascular permeability, volume depletion, thromboembolic events in microvasculature and persistent local inflammation. Besides AKI, SARS-CoV-2 can also cause glomerular disease, as other viral infections such as in HIV, HBV and HCV. HIV-infected patients present chronic inflammation that can lead to a number of renal diseases. Proinflammatory cytokines and TNF-induced apoptosis are some of the underlying mechanisms that may explain the virus-induced renal diseases that are here reviewed.
DOI: 10.6084/m9.figshare.19901747.v1
title: Inflammation and kidney involvement in human viral diseases caused by SARS-CoV-2, HIV, HCV and HBV

description: Abstract Inflammation is closely related to renal diseases. This is particularly true for renal diseases caused by infections as in viral diseases. In this review, we highlight the inflammatory mechanisms that underlie kidney dysfunction in SARS-CoV-2, human immunodeficiency (HIV), hepatitis C (HCV), and hepatitis B (HBV) infections. The pathophysiology of renal involvement in COVID-19 is complex, but kidney damage is frequent, and the prognosis is worse when it happens. Virus-like particles were demonstrated mostly in renal tubular epithelial cells and podocytes, which suggest that SARS-CoV-2 directly affects the kidneys. SARS-CoV-2 uses the angiotensin-converting enzyme 2 receptor, which is found in endothelial cells, to infect the human host cells. Critical patients with SARS-CoV-2-associated acute kidney injury (AKI) show an increase in inflammatory cytokines (IL-1β, IL-8, IFN-γ, TNF-α), known as cytokine storm that favors renal dysfunction by causing intrarenal inflammation, increased vascular permeability, volume depletion, thromboembolic events in microvasculature and persistent local inflammation. Besides AKI, SARS-CoV-2 can also cause glomerular disease, as other viral infections such as in HIV, HBV and HCV. HIV-infected patients present chronic inflammation that can lead to a number of renal diseases. Proinflammatory cytokines and TNF-induced apoptosis are some of the underlying mechanisms that may explain the virus-induced renal diseases that are here reviewed.
DOI: 10.6084/m9.figshare.19901763
title: REACTIVE NITROGEN GASES AS PRECURSORS OF ATMOSPHERIC AEROSOL: FORMATION REACTIONS, GROWTH PROCESSES AND ENVIRONMENTAL IMPLICATIONS

description: The increased emissions of reactive nitrogen gases from anthropogenic sources to the atmosphere has been pointed out as responsible for triggering a series of environmental problems at the local, regional, and global scale. Among the many consequences associated with the excess of reactive nitrogen in the environment is the increase of atmospheric aerosol formation. In this way, the present review article aims to provide an overview of the main aerosol formation reactions from the reactive nitrogen gases, their growth processes, and removal from the atmosphere. The paper also addresses the implications of increasing the atmospheric aerosol load, including effects on the planet’s radiative forcing, cloud formation and precipitation, macronutrient dispersion, visibility and human health. The possible relationship between the long-term exposure to these pollutants and COVID-19 fatality is also discussed. The need for more information related to reactive nitrogen gases and atmospheric aerosols is urgent since they act on fundamental processes on planet Earth and their quantity and composition have been abruptly changed over the last hundred years. Therefore, further investigations on this topic should be stimulated and better integrated in order to guide normative decisions and the delineation of possible solutions.
DOI: 10.6084/m9.figshare.19901763.v1
title: REACTIVE NITROGEN GASES AS PRECURSORS OF ATMOSPHERIC AEROSOL: FORMATION REACTIONS, GROWTH PROCESSES AND ENVIRONMENTAL IMPLICATIONS

description: The increased emissions of reactive nitrogen gases from anthropogenic sources to the atmosphere has been pointed out as responsible for triggering a series of environmental problems at the local, regional, and global scale. Among the many consequences associated with the excess of reactive nitrogen in the environment is the increase of atmospheric aerosol formation. In this way, the present review article aims to provide an overview of the main aerosol formation reactions from the reactive nitrogen gases, their growth processes, and removal from the atmosphere. The paper also addresses the implications of increasing the atmospheric aerosol load, including effects on the planet’s radiative forcing, cloud formation and precipitation, macronutrient dispersion, visibility and human health. The possible relationship between the long-term exposure to these pollutants and COVID-19 fatality is also discussed. The need for more information related to reactive nitrogen gases and atmospheric aerosols is urgent since they act on fundamental processes on planet Earth and their quantity and composition have been abruptly changed over the last hundred years. Therefore, further investigations on this topic should be stimulated and better integrated in order to guide normative decisions and the delineation of possible solutions.
DOI: 10.6084/m9.figshare.19901774
title: Magnetized Biochar as a Gold Nanocatalyst Support for p-Nitrophenol Reduction

description: The biomass use is of considerable ecological and economical interest and here, biochar, a by-product of biomass carbonization, is magnetized with Fe3O4 for its use as gold nanoparticle (NP) support towards catalysis of p-nitrophenol (4-NP) reduction. Biochar was synthesized from coffee straw biomass via pyrolysis, while magnetite functionalization was obtained using the precipitation method. The magnetite was identified by X-ray diffraction (XRD). The material had a specific surface area of 30 m2 g-1 and a zero point charge of 7.5. The gold NPs were deposited via reduction with NaBH4, which yielded Au and Fe3O4 NP of 4.61 and 10.9 nm, respectively. The materials were applied in the 4-NP reduction, Fe3O4Fe 3 O 4 NPs was observed. Remarkably, comparison with graphene oxide to which biochar resembles showed similar behavior, and the material was reused in several catalytic cycles.
DOI: 10.6084/m9.figshare.19901774.v1
title: Magnetized Biochar as a Gold Nanocatalyst Support for p-Nitrophenol Reduction

description: The biomass use is of considerable ecological and economical interest and here, biochar, a by-product of biomass carbonization, is magnetized with Fe3O4 for its use as gold nanoparticle (NP) support towards catalysis of p-nitrophenol (4-NP) reduction. Biochar was synthesized from coffee straw biomass via pyrolysis, while magnetite functionalization was obtained using the precipitation method. The magnetite was identified by X-ray diffraction (XRD). The material had a specific surface area of 30 m2 g-1 and a zero point charge of 7.5. The gold NPs were deposited via reduction with NaBH4, which yielded Au and Fe3O4 NP of 4.61 and 10.9 nm, respectively. The materials were applied in the 4-NP reduction, Fe3O4Fe 3 O 4 NPs was observed. Remarkably, comparison with graphene oxide to which biochar resembles showed similar behavior, and the material was reused in several catalytic cycles.
DOI: 10.6084/m9.figshare.19901802
title: EVALUATION OF THE CHEMICAL COMPOSITION AND STRUCTURE OF ASPHALTENES FROM THREE OFFSHORE BRAZILIAN BIODEGRADED HEAVY OILS

description: Asphaltenes fractions were extracted and purified from three heavy Brazilian oils. Their mass compositions of C, H, N, Ni and V were obtained from elemental analysis and S and O atomic percentages from EDS. The H/C ratios showed high degree of unsaturation, while the O atomic percentages indicated more pronounced biodegradation effects on two samples. Quantitative data on N, Ni, and V and semi-quantitative data on S were related to oils origins. The structural data of asphaltenes were explored by combining Fourier transform infrared spectroscopy (FTIR) and proton nuclear magnetic resonance (1H NMR). The oil with the lower degree of biodegradation contained asphaltenes with a lower level of condensed aromatic rings and longer aliphatic chain substituents. The asphaltenes obtained from the two most biodegraded oils showed similarities of polar groups and the presence of carboxylic functions, as well as lower contents of aliphatic substituents. The quality and quantity of occluded hydrocarbons were assessed after the mild oxidation of the separated asphaltenes fractions. It was suggested that the severe biodegradation which altered these structures may also be responsible to affect their occluded hydrocarbons.
DOI: 10.6084/m9.figshare.19901802.v1
title: EVALUATION OF THE CHEMICAL COMPOSITION AND STRUCTURE OF ASPHALTENES FROM THREE OFFSHORE BRAZILIAN BIODEGRADED HEAVY OILS

description: Asphaltenes fractions were extracted and purified from three heavy Brazilian oils. Their mass compositions of C, H, N, Ni and V were obtained from elemental analysis and S and O atomic percentages from EDS. The H/C ratios showed high degree of unsaturation, while the O atomic percentages indicated more pronounced biodegradation effects on two samples. Quantitative data on N, Ni, and V and semi-quantitative data on S were related to oils origins. The structural data of asphaltenes were explored by combining Fourier transform infrared spectroscopy (FTIR) and proton nuclear magnetic resonance (1H NMR). The oil with the lower degree of biodegradation contained asphaltenes with a lower level of condensed aromatic rings and longer aliphatic chain substituents. The asphaltenes obtained from the two most biodegraded oils showed similarities of polar groups and the presence of carboxylic functions, as well as lower contents of aliphatic substituents. The quality and quantity of occluded hydrocarbons were assessed after the mild oxidation of the separated asphaltenes fractions. It was suggested that the severe biodegradation which altered these structures may also be responsible to affect their occluded hydrocarbons.
DOI: 10.5281/zenodo.6586837
title: Dataset for I. Latella, A. Campa, L. Casetti, P. Di Cintio, J. M. Rubi, and S. Ruffo, Monte Carlo simulations in the unconstrained ensemble, Phys. Rev. E 103, L061303 (2021)

description: This dataset contains data associated to plots published in the paper I. Latella, A. Campa, L. Casetti, P. Di Cintio, J. M. Rubi, and S. Ruffo, Monte Carlo simulations in the unconstrained ensemble, Phys. Rev. E 103, L061303 (2021), https://doi.org/10.1103/PhysRevE.103.L061303
DOI: 10.5281/zenodo.6586836
title: Dataset for I. Latella, A. Campa, L. Casetti, P. Di Cintio, J. M. Rubi, and S. Ruffo, Monte Carlo simulations in the unconstrained ensemble, Phys. Rev. E 103, L061303 (2021)

description: This dataset contains data associated to plots published in the paper I. Latella, A. Campa, L. Casetti, P. Di Cintio, J. M. Rubi, and S. Ruffo, Monte Carlo simulations in the unconstrained ensemble, Phys. Rev. E 103, L061303 (2021), https://doi.org/10.1103/PhysRevE.103.L061303
DOI: 10.6084/m9.figshare.19901826
title: Ketones as Electrophile in Nitroaldol Reaction: Synthesis of β,β-Disubstituted- 1,3-dinitroalkanes and Allylic Nitro Compounds

description: Abstract β,β-Disubstituted-1,3-dinitro compounds were obtained exclusively with an overall yield of 83% through a domino nitroaldol/elimination/1,4-addition process, when excess nitromethane was added to cyclohexanone or butanone using DBU (1,8-diazabicyclo[5.4.0]undec-7-ene), as a basic catalyst. On the other hand, β-nitroalcohols could be obtained in 30-84% yield, when nitromethane reacts with different aliphatic ketones in stoichiometric amounts, in the presence of catalytic amounts of K2CO3(s), Amberlyst® -A21 or TBAF.3H2O (tetra-n-butylammonium fluoride trihydrate)/THF (tetrahydrofuran). In addition, a new and versatile route to obtainment of allylic nitro compounds, by treatment of acetylated nitroalcohols and aldehydes in catalytic amounts of DBU or TBAF.3H2O, via a one-pot elimination/nitroaldol reaction sequence, was developed.
DOI: 10.6084/m9.figshare.19901826.v1
title: Ketones as Electrophile in Nitroaldol Reaction: Synthesis of β,β-Disubstituted- 1,3-dinitroalkanes and Allylic Nitro Compounds

description: Abstract β,β-Disubstituted-1,3-dinitro compounds were obtained exclusively with an overall yield of 83% through a domino nitroaldol/elimination/1,4-addition process, when excess nitromethane was added to cyclohexanone or butanone using DBU (1,8-diazabicyclo[5.4.0]undec-7-ene), as a basic catalyst. On the other hand, β-nitroalcohols could be obtained in 30-84% yield, when nitromethane reacts with different aliphatic ketones in stoichiometric amounts, in the presence of catalytic amounts of K2CO3(s), Amberlyst® -A21 or TBAF.3H2O (tetra-n-butylammonium fluoride trihydrate)/THF (tetrahydrofuran). In addition, a new and versatile route to obtainment of allylic nitro compounds, by treatment of acetylated nitroalcohols and aldehydes in catalytic amounts of DBU or TBAF.3H2O, via a one-pot elimination/nitroaldol reaction sequence, was developed.
DOI: 10.5281/zenodo.6586811
title: Dataset for I. Latella, P. Ben-Abdallah and M. Nikbakht, Radiative thermal rectification in many-body systems, Phys. Rev. B 104, 045410 (2021)

description: This dataset contains data associated to plots published in the paper I. Latella, P. Ben-Abdallah and M. Nikbakht, Radiative thermal rectification in many-body systems, Phys. Rev. B 104, 045410 (2021). https://doi.org/10.1103/PhysRevB.104.045410
DOI: 10.5281/zenodo.6586810
title: Dataset for I. Latella, P. Ben-Abdallah and M. Nikbakht, Radiative thermal rectification in many-body systems, Phys. Rev. B 104, 045410 (2021)

description: This dataset contains data associated to plots published in the paper I. Latella, P. Ben-Abdallah and M. Nikbakht, Radiative thermal rectification in many-body systems, Phys. Rev. B 104, 045410 (2021). https://doi.org/10.1103/PhysRevB.104.045410