cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.28883525
title: Supplementary Material for: GLPG2737, a CFTR Inhibitor, Prevents Cyst Growth in Preclinical Models of Autosomal Dominant Polycystic Kidney Disease

description: Introduction: Autosomal dominant polycystic kidney disease (ADPKD) is a genetic disorder that is characterized by the development of fluid-filled kidney cysts, which often lead to kidney failure. The vasopressin receptor 2 antagonist, tolvaptan, is the only approved treatment that slows the progression of ADPKD. There is an unmet need for treatment options for patients with ADPKD because tolvaptan has limited efficacy and non-negligible side effects. In vitro and in vivo data suggest that inhibition of the cystic fibrosis transmembrane conductance regulator (CFTR) may be a suitable approach to treating ADPKD. Here, we assessed the capacity of GLPG2737, a CFTR inhibitor, to inhibit cyst growth in preclinical models of ADPKD. 

Methods: We investigated the ability of GLPG2737 to modulate CFTR activity in mouse kidney inner medullary collecting duct (mIMCD-3) epithelial cells by measuring chloride flux, and to prevent cyst growth in mIMCD-3 cells, cells from human ADPKD kidney donors, and metanephric organ cultures (MOCs). We assessed cyst volume, kidney weight or volume, and blood urea nitrogen (BUN) in two mouse ADPKD models (Pkd1 kidney-specific knockout mouse model; Pkd1RC/RC mouse model) that received GLPG2737, tolvaptan, or their combination. Statistical tests used for data analysis were based on the normality and variance of the data.

Results: GLPG2737 inhibited chloride flux in mIMCD-3 cells with an IC50 of 2.41 µM. In a 3D assay, GLPG2737 inhibited cyst growth in both wild-type (IC50 = 2.36 µM) and Pkd1 knockout (IC50 = 2.5 µM) mIMCD-3 cells. Preincubation of human ADPKD kidney cells with 10 µM of GLPG2737, 10 µM of tolvaptan, or their combination prevented forskolin-induced cyst growth by 40%, 29%, and 70%, respectively. Furthermore, 10 µM of GLPG2737 inhibited cyst growth in MOCs, decreasing the cyst area by 67% and the number of cysts per area by 46% after 6 days of culture. In both in vivo models, GLPG2737, tolvaptan, or their combination improved the projected cyst volume. In the Pkd1RC/RC model, GLPG2737 also improved the total kidney volume normalized to tibia length (LnTKV) and BUN, while tolvaptan improved the LnTKV and fibrosis but did not lower BUN at sacrifice. The combination reduced all parameters measured in the Pkd1RC/RC model, including cyclic adenosine monophosphate (cAMP) content in the kidneys.

Conclusions: Our findings in preclinical models provide evidence of the therapeutic potential of CFTR inhibition, and its possible combination with tolvaptan. The present work shows that targeting CFTR is a valid strategy to slow ADPKD progression.
DOI: 10.6084/m9.figshare.28883528
title: Supplementary Material for: Efficacy of additional (selective) vidian neurectomy in treating chronic rhinosinusitis with nasal polyp: A systematic review and meta-analysis

description: Introduction: Recently, several reports have been published about the improvement of rhinitis symptoms through posterior nerve ablation. Therefore, we assess the effect of additional (selective) vidian neurectomy in patients with chronic rhinosinusitis with nasal polyp (CRSwNP) compared to conventional endoscopic sinus surgery. 
Methods: We analyzed studies comparing the change of endoscopic findings and patient reporting scores (quality of life and nasal symptoms) related to CRSwNP from baseline (before treatment) to post-treatment between the treatment group (endoscopic sinus surgery plus [selective] vidian neurectomy) and the control group (endoscopic sinus surgery only).
Results: Additional (selective) vidian neurectomy significantly improved the Lund-Kennedy score and sinusitis-related life quality scores compared to the control group. In the subgroup analyses of these results according to neurectomy extent (conventional or selective vidian neurectomy), both types of vidian neurectomy changed the Lund-Kennedy score effectively. Conventional vidian neurectomy showed greater improvement of the patient-reported nasal symptom-related VAS than did selective vidian neurectomy, but there was no significant difference in the changes of sinusitis-related life quality scores between the two groups. Regarding the adverse effects of treatment, conventional vidian neurectomy led to significantly more frequent dry eyes than did selective vidian neurectomy.
Conclusion: Selective vidian neurectomy, when performed in conjunction with endoscopic sinus surgery, provides additional benefits in enhancing endoscopic outcomes and alleviating symptoms in patients with chronic rhinosinusitis with nasal polyps (CRSwNP). Vidian neurectomy can reduce nasal symptoms more effectively than selective vidian neurectomy, but there is no significant difference in sinus-related symptoms and there may be side effects.
DOI: 10.6084/m9.figshare.28883531
title: Supplementary Material for: Clinicopathological features, surgical outcomes and microbial patterns in chronic granulomatous mastitis: A retrospective study from a public hospital in Lima, Peru.

description: Objective: To evaluate the clinicopathological characteristics of patients, surgery-related factors, and microbial patterns in patients diagnosed with chronic granulomatous mastitis treated at a public hospital in Lima, Peru.
Methods: Retrospective study that included 161 women diagnosed with chronic granulomatous mastitis (GM) at the Hospital de Emergencias Grau, Seguro Social de Salud, Lima, Peru, between 2019 and 2021. The diagnosis of GM was established based on anatomical and microbiological criteria. We evaluated clinicopathological features, and factors associated with the need for oncoplastic surgery and post-surgical complications. Additionally, we analyzed 26 out of 161 breast tissue samples to detect the presence of pathogens using Next-Generation Sequencing (NGS).
Results: The average age was 37.7±8.4 years, 53.9% reported the use of hormonal contraceptives, and 14.8% displayed elevated prolactin. Eighty percent of patients received corticosteroids, and 50.9% underwent surgical intervention, with 22.5% experiencing post-surgical complications. Factors associated with the need for surgery included the presence of a tumor, inflammation, shorter disease duration, higher BI-RADS classification, lesion size of 2-5 cm, and corticosteroid use. A recurrence rate of 3.8% was identified. Among the 26 analyzed samples, Corynebacterium was detected in 80.8%, with C. kroppenstedtii identified in 13 of the 26 (50%) samples.
Conclusions: Medical treatment was the initial choice for all patients, nearly half underwent oncoplastic surgery, with some post-surgical complications reported. Nonetheless, chronic GM recurrence was low. Corynebacterium was the most frequently identified genus through NGS.
DOI: 10.15468/dl.qm9hmh
title: Occurrence Download

description: A dataset containing 80 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is China",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "TaxonKey is Eurycorymbus cavaleriei (H.Lév.) Rehder & Hand.-Mazz."
 ]
}

 The dataset includes 80 records from 12 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0006345-250525065834625/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.25549/inscriptifact-ouc110826711
title: Persepolis Fortification Elamite Tablet 2293.105, Fort 2293.105

description: [Text Description:] Administrative text with seal ❧ [Text or Publication Number Note:] Fort 2293.105 ❧ [Excavation Description:] Found during Oriental Institute's excavations in Spring, 1933, near the northeastern corner of the stone platform of Persepolis, in two small rooms of a bastion in the fortification wall ❧ [Medium:] Clay ❧ [Script Note:] Non-Alphabetic Cuneiform ❧ [Physical Object Description:] Clay tablet with cuneiform text. Seal impression on upper edge? ❧ [Physical Object Note:] Upper section of tablet is broken off. Cracks on obverse, reverse.
DOI: 10.25549/inscriptifact-ouc110826700
title: Persepolis Fortification Elamite Tablet 2293.105, Fort 2293.105

description: [Text Description:] Administrative text with seal ❧ [Text or Publication Number Note:] Fort 2293.105 ❧ [Excavation Description:] Found during Oriental Institute's excavations in Spring, 1933, near the northeastern corner of the stone platform of Persepolis, in two small rooms of a bastion in the fortification wall ❧ [Medium:] Clay ❧ [Script Note:] Non-Alphabetic Cuneiform ❧ [Physical Object Description:] Clay tablet with cuneiform text. Seal impression on upper edge? ❧ [Physical Object Note:] Upper section of tablet is broken off. Cracks on obverse, reverse.
DOI: 10.25549/inscriptifact-ouc110826676
title: Persepolis Fortification Elamite Tablet 2293.105, Fort 2293.105

description: [Text Description:] Administrative text with seal ❧ [Text or Publication Number Note:] Fort 2293.105 ❧ [Excavation Description:] Found during Oriental Institute's excavations in Spring, 1933, near the northeastern corner of the stone platform of Persepolis, in two small rooms of a bastion in the fortification wall ❧ [Medium:] Clay ❧ [Script Note:] Non-Alphabetic Cuneiform ❧ [Physical Object Description:] Clay tablet with cuneiform text. Seal impression on upper edge? ❧ [Physical Object Note:] Upper section of tablet is broken off. Cracks on obverse, reverse.
DOI: 10.5281/zenodo.17592678
title: A temática da Educação a Distância em eventos científicos da área de Biblioteconomia: uma análise bibliométrica a partir dos anais do CBBD e SNBU
DOI: 10.25549/inscriptifact-ouc110826671
title: Persepolis Fortification Elamite Tablet 2293.105, Fort 2293.105

description: [Text Description:] Administrative text with seal ❧ [Text or Publication Number Note:] Fort 2293.105 ❧ [Excavation Description:] Found during Oriental Institute's excavations in Spring, 1933, near the northeastern corner of the stone platform of Persepolis, in two small rooms of a bastion in the fortification wall ❧ [Medium:] Clay ❧ [Script Note:] Non-Alphabetic Cuneiform ❧ [Physical Object Description:] Clay tablet with cuneiform text. Seal impression on upper edge? ❧ [Physical Object Note:] Upper section of tablet is broken off. Cracks on obverse, reverse.
DOI: 10.1285/i20705948v10n3p745
title: Devising a fairer method for adjusting target scores in interrupted one-day international cricket

description: One-day international cricket matches face the problem of weather interruption. In such circumstances, a so-called rain rule is used to decide the outcome. A variety of approaches for constructing such rules has been proposed, with the Duckworth-Lewis method being preferred in the sport. There are a number of issues to consider in reasoning about the effectiveness of a rain rule, notably accuracy (does the rule make the right decision?) and fairness (are both teams treated equally?). We develop an approach that is a hybrid of resource-based and so-called probability-preserving approaches and provide empirical evidence that this hybrid method is superior in terms of fairness while competitive in terms of accuracy.
DOI: 10.25549/inscriptifact-ouc110826232
title: Persepolis Fortification Elamite Tablet 2293.105, Fort 2293.105

description: [Text Description:] Administrative text with seal ❧ [Text or Publication Number Note:] Fort 2293.105 ❧ [Excavation Description:] Found during Oriental Institute's excavations in Spring, 1933, near the northeastern corner of the stone platform of Persepolis, in two small rooms of a bastion in the fortification wall ❧ [Medium:] Clay ❧ [Script Note:] Non-Alphabetic Cuneiform ❧ [Physical Object Description:] Clay tablet with cuneiform text. Seal impression on upper edge? ❧ [Physical Object Note:] Upper section of tablet is broken off. Cracks on obverse, reverse.
DOI: 10.25549/inscriptifact-ouc110826227
title: Persepolis Fortification Elamite Tablet 2293.105, Fort 2293.105

description: [Text Description:] Administrative text with seal ❧ [Text or Publication Number Note:] Fort 2293.105 ❧ [Excavation Description:] Found during Oriental Institute's excavations in Spring, 1933, near the northeastern corner of the stone platform of Persepolis, in two small rooms of a bastion in the fortification wall ❧ [Medium:] Clay ❧ [Script Note:] Non-Alphabetic Cuneiform ❧ [Physical Object Description:] Clay tablet with cuneiform text. Seal impression on upper edge? ❧ [Physical Object Note:] Upper section of tablet is broken off. Cracks on obverse, reverse.
DOI: 10.25549/inscriptifact-ouc110826164
title: Persepolis Fortification Elamite Tablet 2293.105, Fort 2293.105

description: [Text Description:] Administrative text with seal ❧ [Text or Publication Number Note:] Fort 2293.105 ❧ [Excavation Description:] Found during Oriental Institute's excavations in Spring, 1933, near the northeastern corner of the stone platform of Persepolis, in two small rooms of a bastion in the fortification wall ❧ [Medium:] Clay ❧ [Script Note:] Non-Alphabetic Cuneiform ❧ [Physical Object Description:] Clay tablet with cuneiform text. Seal impression on upper edge? ❧ [Physical Object Note:] Upper section of tablet is broken off. Cracks on obverse, reverse.
DOI: 10.5281/zenodo.15478540
title: Synchronized observations of sea ice temperature and diffuse attenuation coefficient

description: This dataset comprises synchronous observations of diffuse attenuation coefficients at 443, 488, 531, and 667 nm, along with the corresponding temperatures of thin sea ice.
DOI: 10.5281/zenodo.15478541
title: Synchronized observations of sea ice temperature and diffuse attenuation coefficient

description: This dataset comprises synchronous observations of diffuse attenuation coefficients at 443, 488, 531, and 667 nm, along with the corresponding temperatures of thin sea ice.
DOI: 10.15468/dl.tvth27
title: Occurrence Download

description: A dataset containing 188566 species occurrences available in GBIF matching the query:
{
 "Geometry" : [
 "POLYGON ((33.18264 -10.67257, 36.06141 -10.67257, 36.06141 -7.427288, 33.18264 -7.427288, 33.18264 -10.67257))"
 ]
}

 The dataset includes 188566 records from 367 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0011326-250515123054153/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.4fkv7f
title: Occurrence Download

description: A dataset containing 523 species occurrences available in GBIF matching the query:
{
 "and" : [
 "BasisOfRecord is Human Observation",
 "Country is China",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "TaxonKey is Otis tarda Linnaeus, 1758"
 ]
}

 The dataset includes 523 records from 5 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0011294-250415084134356/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.zcntap
title: Occurrence Download

description: A dataset containing 1555334 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is one of (Aphantopus hyperantus (Linnaeus, 1758))"
 ]
}

 The dataset includes 1555334 records from 1630 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0011282-250415084134356/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.5281/zenodo.15574283
title: The Affective Power of Audio-Visual Politics: Analyzing Political Video Campaigns by Multimodal Approach and Emotional Arcs in the Presidential Elections in Türkiye

description: Links to political campaign videos of two leading candidates in Türkiye 2023 Presidential Elections
DOI: 10.5281/zenodo.15574284
title: The Affective Power of Audio-Visual Politics: Analyzing Political Video Campaigns by Multimodal Approach and Emotional Arcs in the Presidential Elections in Türkiye

description: Links to political campaign videos of two leading candidates in Türkiye 2023 Presidential Elections
DOI: 10.15468/dl.n23zrm
title: Occurrence Download

description: A dataset containing 367 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Ligustrum lucidum",
 "Country is Argentina",
 "HasCoordinate is true"
 ]
}

 The dataset includes 367 records from 10 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0043848-250811113504898/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.xu6wnj
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Ligustrum lucidum",
 "Country is Armenia",
 "HasCoordinate is true"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0043849-250811113504898/datasets/export for details.
DOI: 10.15468/dl.29ukws
title: Occurrence Download

description: A dataset containing 13142 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Ligustrum lucidum",
 "Country is Australia",
 "HasCoordinate is true"
 ]
}

 The dataset includes 13142 records from 30 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0043850-250811113504898/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.fxafs2
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Zosterops paruhbesar",
 "Country is China",
 "HasCoordinate is true"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0043851-250811113504898/datasets/export for details.
DOI: 10.15468/dl.d2tq9p
title: Occurrence Download

description: A dataset containing 1847 species occurrences available in GBIF matching the query:
{
 "and" : [
 "BasisOfRecord is one of (Human Observation, Specimen)",
 "DatasetKey is one of (Colección de Tejidos del Instituto de Investigación de Recursos Biológicos Alexander von Humboldt (IAvH-CT), Colección Ornitológica de la Universidad Industrial de Santander, Academy of Natural Sciences of Philadelphia Ornithology Collection, EOD – eBird Observation Dataset, Xeno-canto - Bird sounds from around the world)",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 "TaxonKey is Thryophilus nicefori"
 ]
}

 The dataset includes 1847 records from 5 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0043852-250811113504898/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.dbmj8c
title: Occurrence Download

description: A dataset containing 1 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Molinia caerulea villosa, Molinia caerulea hispanica, Molinia caerulea littoralis, Molinia caerulea minor, Molinia caerulea varia, Molinia caerulea africana, Molinia caerulea albiflora, Molinia caerulea altissima, Molinia caerulea altissima, Molinia caerulea atrovirens)",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 {
 "not" : {
 "BasisOfRecord" : [
 "is one of (Fossil, Living Specimen, Machine Observation)"
 ]
 }
 },
 "Continent is Europe",
 "Year is greater than or equal to 1980",
 "Year is less than or equal to 2024"
 ]
}

 The dataset includes 1 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0043853-250811113504898/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.hzjnxy
title: Occurrence Download

description: A dataset containing 152 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Ligustrum lucidum",
 "Country is Brazil",
 "HasCoordinate is true"
 ]
}

 The dataset includes 152 records from 38 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0043854-250811113504898/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.gpxrsg
title: Occurrence Download

description: A dataset containing 9 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Ligustrum lucidum",
 "Country is Croatia",
 "HasCoordinate is true"
 ]
}

 The dataset includes 9 records from 3 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0043855-250811113504898/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.b9f7kv
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Ligustrum lucidum",
 "Country is Eswatini",
 "HasCoordinate is true"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0043856-250811113504898/datasets/export for details.
DOI: 10.15468/dl.3w2ta9
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Zosterops auriventer",
 "Country is China",
 "HasCoordinate is true"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0043857-250811113504898/datasets/export for details.
DOI: 10.7910/dvn/qgdjck
title: Interpretative 3D MHD modelling of deuterium SPI into a JET H-mode plasma

description: The pre-thermal quench (pre-TQ) dynamics of a pure deuterium (D2) shattered pellet injection (SPI) into a 3MA/7MJ JET H-mode plasma is studied via 3D non-linear MHD modelling with the JOREK code. The interpretative modelling captures the overall evolution of the measured density and radiated power. The simulations also identify the importance of the drifts of ablation plasmoids towards the tokamak low field side (LFS) and the impurities in the background plasma in fragment penetration, assimilation, radiative cooling and MHD activity in D2 SPI experiments. It is found that plasmoid drifts lead to an about 70% reduction of the central line-integrated density (compared to a simulation without drifts) in the JET D2 SPI discharge considered. Impurities that pre-exist before the SPI as well as those from possible impurity influxes related to the SPI are shown to dominate the radiation in the considered discharge. With inputs from JOREK simulations, modelling with the Lagrangian particle-based pellet code PELOTON reproduces the deviation of the SPI fragments in the direction of the major radius as observed by the fast camera. This confirms the role of rocket effects and plasmoid drifts in the considered discharge and reinforces the validity of the JOREK modelling. The limited core density rise due to plasmoid drifts and the strong radiative cooling and MHD activity with impurities (depending on their species and concentration) could limit the effectiveness of LFS D2 SPI in runaway electron avoidance and are worth considering in the design of the ITER disruption mitigation system.
description: CITATION: M. Kong et al 2024 Nucl. Fusion 64 066004<br><br>PUBLISHED VERSION DOI: http://doi.org/10.1088/1741-4326/ad3b1c<br><br>PSFC REPORT PSFC/JA-24-45<br><br>This work was supported in part by the U.S. Department of Energy, Fusion Energy Sciences Agreement DE-SC0014264.<br><br>If this record does not contain the full text, then the manuscript has been embargoed by the publisher thus restricting open access for 12 to 24 months after publication.
description: B. Stein-Lubrano contributed the data for the "Emis3D" trace of figure 4.