cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.14268353.v1
title: Effect of antihistamine-containing syrup on salivary metabolites: an in vitro and in vivo study

description: Abstract This study tested the null hypothesis that antihistamine-containing syrup does not change salivary metabolites in vitro and in vivo. For the in vitro experiments, saliva from 10 volunteers was mixed with a syrup or pill suspension of loratadine (1 mg/ml Claritin®, Schering-Plough, Rio de Janeiro, Brazil). For the in vivo experiment, 10 volunteers performed a mouth rinse with 10 mL of antihistamine syrup (Claritin®; Schering-Plough, Rio de Janeiro, Brazil) for 20 seconds and then discarded the rinse water. After 20 seconds, 5 mL of unstimulated whole saliva was spit into a plastic tube kept on ice. The protein profile of in vitro and in vivo experiments was analyzed using 12% sodium dodecyl sulfate-polyacrylamide gel electrophoresis. The samples were also analyzed by nuclear magnetic resonance (NMR) spectroscopy, followed by Principal Component Analysis and Wilcoxon test (p &lt; 0.05). There were differences in salivary metabolites after syrup interaction. The salivary concentrations of acetate, n-caproate, arginine, glutamate, and lysine among other metabolites were reduced with the syrup in both in vivo and in vitro experiments (p &lt; 0.05), but no differences were observed when the pill suspension was used (p &gt; 0.05). Similar changes in metabolite profiles were observed in both in vitro and in vivo experiments. Electrophoresis revealed no difference in the salivary protein pattern. The null hypothesis was rejected because the intake of syrup medicine changes the salivary composition and influences oral homeostasis and susceptibility to oral diseases.
DOI: 10.6084/m9.figshare.14268152
title: A necessary discussion on consumer vulnerability: advances, gaps, and new perspectives

description: Abstract Consumer research is not usually concerned with problems caused or aggravated by market activities. However, economic, social, environmental, and public health problems can be attributed to certain market practices, which are harmful to different market agents. This article examines how consumer vulnerability has been discussed in the marketing and consumer literature through a national and international literature review of the last 25 years. It seeks to identify the different perspectives and definitions in researches that discuss the topic and suggests a comprehensive definition of vulnerability in the marketing area, which considers the vulnerability of other agents. We identified vulnerability as an issue gaining importance, despite the predominance of a managerialist perspective, which emphasizes the generation of knowledge that benefits companies. It seems urgent that marketing and consumer studies are interested in knowledge that protects and benefits consumers and society in general. We believe that the study of vulnerability should also encourage the development of adequate public policies and the discussion of regulatory activities, in addition to the consumer. Thus, from the results, we suggest that vulnerability can be defined as a state of individuals’ fragility in the face of market practices, which can manifest in different stages in production, commercialization, and consumption processes.
DOI: 10.6084/m9.figshare.14268152.v1
title: A necessary discussion on consumer vulnerability: advances, gaps, and new perspectives

description: Abstract Consumer research is not usually concerned with problems caused or aggravated by market activities. However, economic, social, environmental, and public health problems can be attributed to certain market practices, which are harmful to different market agents. This article examines how consumer vulnerability has been discussed in the marketing and consumer literature through a national and international literature review of the last 25 years. It seeks to identify the different perspectives and definitions in researches that discuss the topic and suggests a comprehensive definition of vulnerability in the marketing area, which considers the vulnerability of other agents. We identified vulnerability as an issue gaining importance, despite the predominance of a managerialist perspective, which emphasizes the generation of knowledge that benefits companies. It seems urgent that marketing and consumer studies are interested in knowledge that protects and benefits consumers and society in general. We believe that the study of vulnerability should also encourage the development of adequate public policies and the discussion of regulatory activities, in addition to the consumer. Thus, from the results, we suggest that vulnerability can be defined as a state of individuals’ fragility in the face of market practices, which can manifest in different stages in production, commercialization, and consumption processes.
DOI: 10.6084/m9.figshare.14268165
title: Effect of seed vigor and sowing densities on the yield and physiological potential of wheat seeds

description: Abstract: Initial seed vigor and sowing density interact in establishment of plants in the field, and can thus affect expression of the plasticity of the wheat crop and the yield and physiological quality of the seeds produced. The aim of this study was to evaluate the effect of seed vigor levels in combination with sowing densities on the yield and physiological potential of wheat seeds. The cultivars BRS Gralha-Azul and BRS Sabiá were used in a randomized block experimental design in a 2 × 4 factorial arrangement, with four replications. The treatments consisted of seeds of high and low vigor and four sowing densities (150, 250, 350, and 450 seeds.m-2). The following evaluations were made: seed yield, germination, first germination count, seedling length, seedling dry matter, accelerated aging, emergence speed index, and seedling emergence in sand. An increase in sowing density favors the seed yield of both cultivars; however, it reduces the vigor of the seeds produced by the cultivar BRS Gralha-Azul, especially of the seeds produced by plants originating from high vigor seeds. For the cultivar BRS Sabiá, an increase in sowing density decreases the germination performance of seeds produced by plants originating from low vigor seeds.
DOI: 10.6084/m9.figshare.14268269
title: Antioxidant enzyme activity in germination of Dalbergia spruceana seeds under different temperatures

description: Abstract: Antioxidant enzyme activity can be used to measure heat stress and predict the tolerance of a species to heat stress. This study investigated the effects of temperature on germination and antioxidant enzyme activity in Dalbergia spruceana Benth. seeds. Seeds were incubated at constant temperatures of 20, 25, 30, 35, and 40 °C for ten days; and germination percentage, germination speed index, antioxidant enzyme activity, and electrical conductivity were evaluated. Temperature affected the seed germination process but not antioxidant enzyme activity. Germination percentage and germination speed index were higher at 25 and 35 °C and lower at 20 and 40 °C. Superoxide dismutase activity was not affected by temperature. Catalase and peroxidase activities were too low to be used as indicators of temperature stress. The pattern of increasing electrolyte leakage manifested a trend toward loss of cell membrane semipermeability at higher temperatures.
DOI: 10.6084/m9.figshare.14268269.v1
title: Antioxidant enzyme activity in germination of Dalbergia spruceana seeds under different temperatures

description: Abstract: Antioxidant enzyme activity can be used to measure heat stress and predict the tolerance of a species to heat stress. This study investigated the effects of temperature on germination and antioxidant enzyme activity in Dalbergia spruceana Benth. seeds. Seeds were incubated at constant temperatures of 20, 25, 30, 35, and 40 °C for ten days; and germination percentage, germination speed index, antioxidant enzyme activity, and electrical conductivity were evaluated. Temperature affected the seed germination process but not antioxidant enzyme activity. Germination percentage and germination speed index were higher at 25 and 35 °C and lower at 20 and 40 °C. Superoxide dismutase activity was not affected by temperature. Catalase and peroxidase activities were too low to be used as indicators of temperature stress. The pattern of increasing electrolyte leakage manifested a trend toward loss of cell membrane semipermeability at higher temperatures.
DOI: 10.6084/m9.figshare.14268168
title: Open Government Partnership in São Paulo City and the São Paulo Aberta program: challenges in the diffusion and institutionalization of a global policy

description: Abstract Brasil ha sido un lugar importante para implementar prácticas participativas después de su democratización. En 2011, junto con otros siete gobiernos fundadores, Brasil respaldó la Alianza para el de Gobierno Abierto (OGP) y anunció los planes del país para promover una mayor transparencia en las prácticas gubernamentales. El país se convirtió en parte de una iniciativa multilateral que hoy reúne a más de 70 países. Desde su difusión internacional, esta iniciativa fue incorporada por la ciudad de San Pablo, que creó el Comité Intersecretarial de Gobierno Abierto en 2014. Describimos la incorporación de la OGP y de su proceso de difusión y discutimos los desafíos de difusión e institucionalización de una política global a nivel local, entre 2013 y 2016. Las principales conclusiones abordan la importancia de institucionalizar las prácticas políticas además de la difusión de políticas; la importancia del análisis microinstitucional y del trabajo institucional en la teoría organizacional para comprender la importancia de los actores clave en el proceso de implementación; y la influencia de la arquitectura institucional en la implementación de la OGP.
DOI: 10.6084/m9.figshare.14268165.v1
title: Effect of seed vigor and sowing densities on the yield and physiological potential of wheat seeds

description: Abstract: Initial seed vigor and sowing density interact in establishment of plants in the field, and can thus affect expression of the plasticity of the wheat crop and the yield and physiological quality of the seeds produced. The aim of this study was to evaluate the effect of seed vigor levels in combination with sowing densities on the yield and physiological potential of wheat seeds. The cultivars BRS Gralha-Azul and BRS Sabiá were used in a randomized block experimental design in a 2 × 4 factorial arrangement, with four replications. The treatments consisted of seeds of high and low vigor and four sowing densities (150, 250, 350, and 450 seeds.m-2). The following evaluations were made: seed yield, germination, first germination count, seedling length, seedling dry matter, accelerated aging, emergence speed index, and seedling emergence in sand. An increase in sowing density favors the seed yield of both cultivars; however, it reduces the vigor of the seeds produced by the cultivar BRS Gralha-Azul, especially of the seeds produced by plants originating from high vigor seeds. For the cultivar BRS Sabiá, an increase in sowing density decreases the germination performance of seeds produced by plants originating from low vigor seeds.
DOI: 10.6084/m9.figshare.14268168.v1
title: Open Government Partnership in São Paulo City and the São Paulo Aberta program: challenges in the diffusion and institutionalization of a global policy

description: Abstract Brasil ha sido un lugar importante para implementar prácticas participativas después de su democratización. En 2011, junto con otros siete gobiernos fundadores, Brasil respaldó la Alianza para el de Gobierno Abierto (OGP) y anunció los planes del país para promover una mayor transparencia en las prácticas gubernamentales. El país se convirtió en parte de una iniciativa multilateral que hoy reúne a más de 70 países. Desde su difusión internacional, esta iniciativa fue incorporada por la ciudad de San Pablo, que creó el Comité Intersecretarial de Gobierno Abierto en 2014. Describimos la incorporación de la OGP y de su proceso de difusión y discutimos los desafíos de difusión e institucionalización de una política global a nivel local, entre 2013 y 2016. Las principales conclusiones abordan la importancia de institucionalizar las prácticas políticas además de la difusión de políticas; la importancia del análisis microinstitucional y del trabajo institucional en la teoría organizacional para comprender la importancia de los actores clave en el proceso de implementación; y la influencia de la arquitectura institucional en la implementación de la OGP.
DOI: 10.6084/m9.figshare.14268174
title: GEOGRAPHICAL TRAJECTORY OF FORESTRY IN MINAS GERAIS, BRAZIL

description: Abstract From the Historical Geography perspective, we aimed at understanding how the expansion of forestry in Minas Gerais occurred, by pursuing a synchronic and diachronic investigation of the used territory. We verified that public policies, the partnership between university-industry and the advances in silvicultural techniques as well drove the trajectory of forestry in the state, particularly of eucalyptus. In addition, the evolution of the reforestation took place from the south of the state to regions of flat relief and low land cost, consolidating in the North and in the Jequitinhonha Valley.
DOI: 10.6084/m9.figshare.14268174.v1
title: GEOGRAPHICAL TRAJECTORY OF FORESTRY IN MINAS GERAIS, BRAZIL

description: Abstract From the Historical Geography perspective, we aimed at understanding how the expansion of forestry in Minas Gerais occurred, by pursuing a synchronic and diachronic investigation of the used territory. We verified that public policies, the partnership between university-industry and the advances in silvicultural techniques as well drove the trajectory of forestry in the state, particularly of eucalyptus. In addition, the evolution of the reforestation took place from the south of the state to regions of flat relief and low land cost, consolidating in the North and in the Jequitinhonha Valley.
DOI: 10.6084/m9.figshare.14268179
title: Effect of S. mutans combinations with bifidobacteria/lactobacilli on biofilm and enamel demineralization

description: Abstract The present study evaluated the ability of Bifidobacterium and Lactobacillus species associated with streptococci to increase insoluble extracellular polysaccharide (EPS) production and initial caries lesion progression. Bovine enamel blocks (n = 190; 4 mm x 4 mm) were prepared, selected according to initial surface hardness (SH), and divided into two groups: a) double combinations: S. mutans with Bifidobacterium or Lactobacillus, and b) triple combinations: S. mutans and S. sobrinus with Bifidobacterium or Lactobacillus species. The blocks were exposed to the bacterial associations for 7 days. Subsequently, quantity of EPS from biofilms and caries lesion depth were determined by means of colorimetric and cross-sectional enamel hardness (ΔKHN) analysis. The data were submitted to one-way analysis of variance, followed by the Bonferroni test (p &lt; 0.05). S. mutans with B. animalis or B. dentium produced a higher quantity of EPS; S. mutans + B. animalis led to the highest ∆KHN. S. mutans + S. sobrinus + B. longum induced greater EPS and ∆KHN values. In conclusion, associations of B. animalis and B. longum with streptococci promoted EPS production and caries lesion progression.
DOI: 10.6084/m9.figshare.14268179.v1
title: Effect of S. mutans combinations with bifidobacteria/lactobacilli on biofilm and enamel demineralization

description: Abstract The present study evaluated the ability of Bifidobacterium and Lactobacillus species associated with streptococci to increase insoluble extracellular polysaccharide (EPS) production and initial caries lesion progression. Bovine enamel blocks (n = 190; 4 mm x 4 mm) were prepared, selected according to initial surface hardness (SH), and divided into two groups: a) double combinations: S. mutans with Bifidobacterium or Lactobacillus, and b) triple combinations: S. mutans and S. sobrinus with Bifidobacterium or Lactobacillus species. The blocks were exposed to the bacterial associations for 7 days. Subsequently, quantity of EPS from biofilms and caries lesion depth were determined by means of colorimetric and cross-sectional enamel hardness (ΔKHN) analysis. The data were submitted to one-way analysis of variance, followed by the Bonferroni test (p &lt; 0.05). S. mutans with B. animalis or B. dentium produced a higher quantity of EPS; S. mutans + B. animalis led to the highest ∆KHN. S. mutans + S. sobrinus + B. longum induced greater EPS and ∆KHN values. In conclusion, associations of B. animalis and B. longum with streptococci promoted EPS production and caries lesion progression.
DOI: 10.6084/m9.figshare.14268173
title: Immediate outcome of endovascular treatment of ruptured juxtarenal aneurysm with parallel stents

description: Abstract Rupture of an abdominal aortic aneurysm is an event with a high mortality rate and treatment is a medical emergency. Endovascular treatment of these aneurysms has become established as a minimally invasive alternative to classical open surgery and is now the first-choice option. However, 20 to 50% of patients with abdominal aortic aneurysms do not have anatomy favorable for endovascular treatment because of a short aneurysm neck or because visceral branches are involved by the aneurysm. We report the case of a 70-year-old patient who underwent endovascular repair of a ruptured juxtarenal aneurysm with deployment of parallel stents in the renal arteries (in a chimney technique). Clinical data and details of the procedure are reported. Technical success was achieved and there were no postoperative complications.
DOI: 10.6084/m9.figshare.14268173.v1
title: Immediate outcome of endovascular treatment of ruptured juxtarenal aneurysm with parallel stents

description: Abstract Rupture of an abdominal aortic aneurysm is an event with a high mortality rate and treatment is a medical emergency. Endovascular treatment of these aneurysms has become established as a minimally invasive alternative to classical open surgery and is now the first-choice option. However, 20 to 50% of patients with abdominal aortic aneurysms do not have anatomy favorable for endovascular treatment because of a short aneurysm neck or because visceral branches are involved by the aneurysm. We report the case of a 70-year-old patient who underwent endovascular repair of a ruptured juxtarenal aneurysm with deployment of parallel stents in the renal arteries (in a chimney technique). Clinical data and details of the procedure are reported. Technical success was achieved and there were no postoperative complications.
DOI: 10.6084/m9.figshare.14268429
title: Design, synthesis, and evaluation of Bothrops venom serine protease peptidic inhibitors

description: Abstract Background: In Central and South America, snakebite envenomation is mainly caused by Bothrops spp. snakes, whose venoms feature significant biochemical richness, including serine proteases. The available bothropic antivenoms are efficient in avoiding fatalities, but do not completely neutralize venom serine proteases, which are co-responsible for some disorders observed during envenomation. Methods: In order to search for tools to improve the antivenom’s, 6-mer peptides were designed based on a specific substrate for Bothrops jararaca venom serine proteases, and then synthesized, with the intention to selectively inhibit these enzymes. Results: Using batroxobin as a snake venom serine protease model, two structurally similar inhibitor peptides were identified. When tested on B. jararaca venom, one of the new inhibitors displayed a good potential to inhibit the activity of the venom serine proteases. These inhibitors do not affect human serine proteases as human factor Xa and thrombin, due to their selectivity. Conclusion: Our study identified two small peptides able to inhibit bothropic serine proteases, but not human ones, can be used as tools to enhance knowledge of the venom composition and function. Moreover, one promising peptide (pepC) was identified that can be explored in the search for improving Bothrops spp. envenomation treatment.
DOI: 10.6084/m9.figshare.14268433
title: Reliability and geotechnical safety applied to deep foundations in precast concrete piles - case study

description: Abstract The Brazilian standard pertinent to the design and execution of foundations, NBR 6122/2019, establishes that the safety inspection of foundations of a given project must be conducted based on compliance with specified safety factors. Safety factor verification is imperative to meet regulatory requirements; however, it is not enough to guarantee the safety of a foundation. As there is variability in the resistance and solicitation of the piles that make up a foundation, each safety factor value reflects a failure probability. Therefore, it is fictitious that the use of an adequate safety factor value implies the absence of failure risk. Thus, a reliability analysis, applied to a real building with an access ramp whose foundations are composed of precast concrete piles, based on the probabilistic moments, mean, and coefficient of variation, associated with the variability of pile resistance and solicitation, is presented in this article. The values obtained for the safety factors (2.14 and 1.98 for the building and the ramp foundations, respectively) and failure probabilities (1:2,244 and 1:3,131 for the building and the ramp foundations, respectively) implies that the project in question has an acceptable safety level. This article allows us to conclude that a small variation in the reliability index results in a large variation in failure probability; that a greater global safety factor does not necessarily lead to a lower failure probability and it becomes evident that this reliability analysis is a practical way, to manage the uncertainties inherent in foundation design, allowing rational decision making regarding performance.
DOI: 10.6084/m9.figshare.14268429.v1
title: Design, synthesis, and evaluation of Bothrops venom serine protease peptidic inhibitors

description: Abstract Background: In Central and South America, snakebite envenomation is mainly caused by Bothrops spp. snakes, whose venoms feature significant biochemical richness, including serine proteases. The available bothropic antivenoms are efficient in avoiding fatalities, but do not completely neutralize venom serine proteases, which are co-responsible for some disorders observed during envenomation. Methods: In order to search for tools to improve the antivenom’s, 6-mer peptides were designed based on a specific substrate for Bothrops jararaca venom serine proteases, and then synthesized, with the intention to selectively inhibit these enzymes. Results: Using batroxobin as a snake venom serine protease model, two structurally similar inhibitor peptides were identified. When tested on B. jararaca venom, one of the new inhibitors displayed a good potential to inhibit the activity of the venom serine proteases. These inhibitors do not affect human serine proteases as human factor Xa and thrombin, due to their selectivity. Conclusion: Our study identified two small peptides able to inhibit bothropic serine proteases, but not human ones, can be used as tools to enhance knowledge of the venom composition and function. Moreover, one promising peptide (pepC) was identified that can be explored in the search for improving Bothrops spp. envenomation treatment.