cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.19298807.v2
title: Primary Screening

description: Primary screening results table linked to "Cytopathic SARS-CoV-2 screening on VERO-E6 cells in a large-scale repurposing effort"
DOI: 10.6084/m9.figshare.28423577.v1
title: Mechanically deformable organic ferroelectric crystal with plasticity optimized by fluorination

description: Related properties of a ferroelectric.
DOI: 10.6084/m9.figshare.14422208.v1
title: Data_Microcoleus.zip

description: This figshare file contains the data used in Stanojković et al. entitled "Geography and climate drive the distribution and diversification of the cosmopolitan cyanobacterium Microcoleus (Oscillatoriales, Cyanobacteria)". The dataset includes README.txt file.<br>
DOI: 10.6084/m9.figshare.28104740.v1
title: The Effect of Physical Exercise on Subjective Well-Being of Older Adults-Based on a Mediating Role Study.xlsx

description: Luo he has a large elderly population and faces the challenge of an ageing population. In this study, elderly people aged 60 years and above in Luo he City were selected as survey respondents, and convenience sampling was used to try to conduct the survey according to different ages, educational levels, incomes, and male/female ratios. It took one month to conduct an offline survey through offline face-to-face communication with 339 elderly people aged 60 and above in Luo he City (Yuan hui District, Zhao ling District, and Placebo District). The content of the questionnaire was clarified to the subjects prior to the survey and was dictated by the researcher with the consent of the subjects and their families to ensure that each question was filled in with full understanding of its meaning. At the end of the overall survey, the data were checked and 25 questionnaires that were not filled out according to the specifications or omitted were excluded, and a total of 314 valid questionnaires were recovered, with a validity rate of 93%.
DOI: 10.6084/m9.figshare.24958548.v1
title: Supplementary Material for: Pterin Profiling in Serum, Dried Blood Spot and Urine Samples Using LC-MS/MS in Patients With Inherited Hyperphenylalaninemia

description: Background Hyperphenylalaninemia (HPA) is defined as blood phenylalanine (Phe) levels exceeding the normal values (&gt;120 µmol/L or &gt;2 mg/dL), and is caused by a deficiency in the enzyme phenylalanine hydroxylase (PAH). The widespread screening of Phe levels in newborn screening programs has led to a very high number of patients with HPA. 
Methods Nine pterin derivatives, including isoxanthopterin, sepiapterin, xanthopterin, primapterin, biopterin, neopterin, 7,8-dihydrobiopterin, 7,8-dihydroneopterin and tetrahydrobiopterin (BH4), were analyzed in different HPA classes in serum, dried blood spots (DBS) and urine samples. A total of 18 patients, including six classical phenylketonuria (PKU), eight BH4-responsive PKU and four mild HPA patients, were included in the study. 
Results Among the nine pterin derivatives measured, a significant increase was observed in the levels of isoxanthopterin, biopterin, and 7,8-dihydrobiopterin in serum, dried blood spots (DBS), and urine samples of patients with HPA compared to the control group. However, elevations in isoxanthopterin, biopterin, and 7,8-dihydrobiopterin were observed in all HPA groups, although the extent of elevation varied among the different disease groups. There were also significant differences between HPA subgroups among these high values.
Conclusion In this study, it might be suggested that pterin profiling shows promising potential for its effective utilization in the differential diagnosis of HPA. Pterin profiling demonstrated its efficacy in accurately categorizing patients into distinct subtypes. This approach offers several notable advantages, including the ability to simultaneously screen multiple HPA subtypes through a single test, establish disease decision limits for pterins, shorten the time required for HPA differential diagnosis, reduce the risk of misdiagnosis, and increase overall diagnostic accuracy. This study is the most comprehensive study examining the association between HPA pterin in the literature. In our study, samples obtained from BH4-responsive PKU patients were on treatment. This may have affected the results. Preliminary findings on pterin profiles may need to be replicated in a prospective cohort of samples collected at the time of diagnosis to confirm the results.
DOI: 10.6084/m9.figshare.27968289.v1
title: Deliverable 02 | CT-EX2023D869221-101 | Spatial maps of climate-driven risk to European forests

description: Projected biomass loss in European forests due to fires, windthrows, and insect outbreaks are generated by integrating machine learning models of forest disturbances with current forest structure and projected climate. Forest structural variables are derived from Earth observations, whereas future climate is based on EURO-CORDEX experiments under RCP4.5 and RCP8.5. Simulated risk are provided for the 1981-2100 period at 0.1° spatial resolution and expressed in terms of tons of biomass loss per hectare. The folders "fire", "wind", and "insect" contain maps of annual risk estimates caused by projected fires, windthrows, and insect outbreaks, respectively. Machine learning models are based on the following studies:- Forzieri, G. et al. Emergent vulnerability to climate-driven disturbances in European forests. Nature Communications 12, (2021).- Forzieri, G. et al. Ecosystem heterogeneity is key to limiting the increasing climate-driven risks to European forests. One Earth (2024)<br>
DOI: 10.6084/m9.figshare.16436892.v1
title: Supplementary Material for: Association of Hypertension with Mild Cognitive Impairment in Population from Less-Developed Areas of Multiethnic Northwest China

description: <b><i>Background:</i></b> Relationship between hypertension and mild cognitive impairment (MCI) remains undetermined in population from less-developed regions. We aimed to explore whether hypertension is associated with MCI in this specific population. <b><i>Methods:</i></b> In this cross-sectional study, we enrolled subjects aged ≥18 years using multistage random sampling from Emin, China, in 2019. Participants underwent questionnaires and data collection including mini-mental state examination (MMSE) and blood pressure measurement. <b><i>Results:</i></b> Finally, 31,329 subjects were included, with 11,270 hypertensives. Compared with normotensive subjects, hypertensives were characterized by significantly older age (55.19 ± 12.25 vs. 43.26 ± 12.71), more men (52.5% vs. 42.9%), low education attainment (≤primary education: 42.4% vs. 26.3%), more abdominal obesity (39.7% vs. 19.1%), poor sleep quality (39.1% vs. 28.7%), and chronic kidney disease (6.6% vs. 3.4%, <i>p</i> for all &lt;0.001). Prevalence of MCI in hypertensives was significantly higher than that of normotensive subjects (24.3% vs. 15.6%, <i>p</i> &lt; 0.001). Multivariate logistic regression analysis showed in a fully adjusted model that the odds for MCI were significantly increased in hypertensives than in normotensive population (OR = 1.19, 95% CI: 1.09, 1.30, <i>p</i> &lt; 0.001) and independent of all the parameters studied including age, education level, and stroke. In the age-stratified regression model, presence of hypertension significantly increased the odds of MCI by 1.17-fold (95% CI: 1.03, 1.33, <i>p</i> = 0.020) and by 1.22-fold (95% CI: 1.04, 1.44, <i>p</i> = 0.016) in middle-aged and elderly population. Sensitivity analysis of excluding those with stroke history showed that hypertension was still a risk factor for MCI in total, middle-aged, and elderly population. <b><i>Conclusion:</i></b> Hypertension is in independent negative association with MCI in middle-aged and elderly population from underdeveloped regions.
DOI: 10.6084/m9.figshare.19120856.v1
title: The fluorescent introduction has begun in the southern hemisphere: presence and life-history strategies of the transgenic zebrafish <i>Danio rerio</i> (Cypriniformes: Danionidae) in Brazil

description: Transgenic ornamental fish that fluoresce are becoming popular in the aquarium trade worldwide. Some transgenic zebrafish (TZF) records in natural water bodies have been published, but there are no data on their biological attributes in the new areas. This study aimed to evaluate the distribution, trophic ecology, and reproductive condition of the non-native TZF in headwater creeks located in the largest Brazilian ornamental aquaculture center. Insect fragments – identified as chitinous material in the ‘false stomach’- and aquatic insects were the most consumed item. TZF adults were found in breeding conditions during almost all sampling periods. The Gonadosomatic Index of females and males showed peaks during the rainy season and matched with the rising water levels. Breeding females and males were found at small body sizes, indicating early maturation, and these transgenic females produced a moderate amount of small oocytes. Sex-ratio assessment showed that females and males had the same frequencies in one site, while females were significantly more frequent than males at another location. Management recommendations, such as utilization of best management practices (e.g. screens on outlets), not using unapproved genetically modified organisms in aquaculture, and awareness with fish farmers about transgenic animals, are suggested to avoid new introductions.
DOI: 10.6084/m9.figshare.27323064.v1
title: Super pangenome of<i> Vitis</i> empowers identification of downy mildew resistance genes for grapevine improvement

description: Grapevine (Vitis) is one of the oldest domesticated fruit crops with great cultural and economic importance. Here, we assembled and annotated haplotype-resolved genomes of 72 global Vitis accessions including 25 wild and 47 cultivated grapevines, among which genomes for 60 grapevines are newly released. Haplotype-aware phylogenomics disentangled the mysterious hybridization history of grapevines, revealing enormous genetic diversity of Vitis genus. Pangenomic analysis reveals that European cultivars, more susceptible to the most destructive disease downy mildew (DM), have a smaller repertoire of resistance genes in NLR family encoding the TIR-NBARC-LRR domain. Through extensive structural variation (SV) characterization, phenotyping, DM-infection transcriptome profiling of 113 Vitis accessions, and SV-eQTL analysis, we have identified over 63 SVs and their relevant genes significantly associated with DM resistance, exemplified by a lysine histidine transporter, VvLHT8. This haplotype-resolved super pangenome of Vitis genus will accelerate breeding and enrich our understanding of the evolution and biology of grapevines.
DOI: 10.6084/m9.figshare.19426739.v1
title: pnas_dataset.csv

description: <b>About Dataset</b><br>Context<br>The dataset is acquired via the VIRRION platform designed for label-free capture and enrichment of viruses. It consists of Raman spectra of three groups of RNA viruses, including human respiratory viruses (influenza A H1N1 and H3N2, influenza B, rhinovirus, respiratory syncytial virus (RSV)), avian respiratory viruses (influenza A H5N2 and H7N2, infectious bronchitis virus (IBV), reovirus), and human enteroviruses (Coxsackievirus B type 1 and 3 (CVB1, CVB3), enteroviruses EV70 and EV71).<br>Content<br>Each row in the dataset describes:<br>1. the intensity of a raman spectrum at each wavenumber specified by the numerical column names;2. the corresponding label (virus type/subtype) of each raman spectrum specified by the column name 'label';<br>Acknowledgements<br>...<br>
DOI: 10.6084/m9.figshare.3188767.v3
title: Early farmers from across Europe directly descended from Neolithic Aegeans—Hofmanová et al., 3D figure S4

description: Three-dimensional PCA of modern reference populations and projected ancient individuals. The Greek and Anatolian samples reported here cluster tightly with other European farmers close to modern-day Sardinians, however, are clearly distinct from previously published Caucasian hunter-gatherers. This excludes the latter as potential ancestral source population for early European farmers and suggests strong genetic structure in hunter-gatherers of southwest Asia. A two-dimensional version including the legend explaining the colour code are part of Figure 2 of the main text.
DOI: 10.6084/m9.figshare.3559857.v1
title: Appendix C. Supplemental figures and tables detailing the impact of nutrients and enrichment conditions on additional metrics of coral growth and photobiology.

description: Supplemental figures and tables detailing the impact of nutrients and enrichment conditions on additional metrics of coral growth and photobiology.
DOI: 10.6084/m9.figshare.6954857.v1
title: Supplementary Material for: Mortality Effects of Prolonged Hemoperfusion Therapy Using a Polymyxin B-Immobilized Fiber Column for Patients with Septic Shock: A Sub-Analysis of the DESIRE Trial

description: <b><i>Background/Aims:</i></b> The optimal duration of hemoperfusion therapy with a polymyxin B-immobilized fiber column has not yet been verified. <b><i>Methods:</i></b> This analysis examined whether hemoperfusion therapy with a polymyxin B-immobilized fiber column lasting longer than 2 h (prolonged polymyxin) improved outcomes for patients with septic shock compared to 2-h polymyxin therapy (sub-analysis of data from the DESIRE trial). <b><i>Results:</i></b> The 2-h and prolonged polymyxin groups contained 22 and 14 patients, respectively. Both groups had similar characteristics. The polymyxin duration per session in the prolonged polymyxin group was significantly longer (median, 5.5 h) than in the 2-h polymyxin group (<i>p</i> &lt; 0.01). The 28-day mortality rate was significantly higher in the 2-h polymyxin group (7, 31.8%) than in the prolonged polymyxin group (0, 0%; <i>p</i> = 0.019). <b><i>Conclusion:</i></b> Prolonged polymyxin therapy might be associated with better clinical outcomes than 2-h polymyxin therapy in patients with septic shock. Video Journal Club “Cappuccino with Claudio Ronco” at http://www.karger.com/?doi=491744.
DOI: 10.6084/m9.figshare.23608119.v1
title: Supplementary Material for: The 'Weekday effect' on Enhanced Recovery After Surgery Protocol for Gastrectomy

description: Introduction: While Enhanced Recovery After Surgery (ERAS) protocol demonstrated to improve outcomes after gastrectomy, some papers evidenced a detrimental effect on postoperative morbidity related to the "weekday effect". We aimed to understand whether the day of gastrectomy could affect postoperative outcomes and compliance with ERAS items. Methods: We included all patients that underwent gastrectomy for cancer between January 2017 and September 2021. Cohort was divided considering the day of surgery: Early group (Monday-Wednesday) and Late group (Thursday-Friday). Compliance with protocol and postoperative outcomes were compared. Results: 227 patients were included in Early group, while 154 in Late group. The groups were comparable in pre-operative characteristics. No significant difference in pre/intraoperative and postoperative ERAS items' compliance was apparent between Early and Late groups, with most items exceeding the 70% threshold. Median length of stay was 6.5 days and 6 days in Early and Late groups (p=0.616), respectively. Morbidity was 50% in both groups, with severe complications that occurred in 13% of Early patients and 15% of Late patients. Ninety-day mortality was 2%, and it was similar between the two groups. Conclusions: In a Center with a standardized ERAS protocol, the weekday of gastrectomy has no significant impact on the success of each ERAS item and on postoperative surgical and oncological outcomes.
DOI: 10.6084/m9.figshare.16802056.v1
title: Plume-lithosphere Interaction and Delamination at Yellowstone and its Implications for the Boundary of Craton Stability

description: This file contains all the modelling data generated in the paper. Under each directory, there are different kinds of files: hfaac*.txt are for composition data; hfaact* are for temperature data; hfaau* are for velocity data, hfaav* are for viscosity data, hfaae* are for the strain rate data.vis_c_t.m, vis_u_v.m, and vis_e are used for plotting composition and temperature, velocity and viscosity, and strain rate fields in Matlab.
DOI: 10.6084/m9.figshare.18241244.v1
title: Impact of domestic investment on the FDI-growth relationship

description: <i>Empirical puzzle regarding the FDI-growth relationship has recently been explained in terms of the host country’s absorptive capacities. Countries with good absorptive capacity tend to harness benefits while others experience negative impacts from FDI. Nonetheless, extant literature fails to recognize the importance of domestic investment in explaining the growth productivity of foreign capitals. This paper, therefore, examines if the level of domestic investment in developing countries can affect the relationship between growth and FDI inflows. It is unveiled that irrespective of the level of domestic investment, the inflow of foreign capital leads to the displacement of local firms, thereby, experiencing zero or negative net impact of foreign capital on income growth of developing countries. We propose that national leaders must carefully assess MNC’s impact on the local economy before making any decisions regarding FDI and related policies.</i>
DOI: 10.6084/m9.figshare.22120514.v2
title: Teacher's Perceptions Regarding Role Playing Activities, Empathy Skills and Comforting Behavior. Empathy Skills and Comforting Behaviors Through Role-Playing in Early Childhood Education: A Phenomenological Study

description: Teacher's Perceptions Regarding Role Playing Activities, Empathy Skills and Comforting Behavior. Empathy Skills and Comforting Behaviors Through Role-Playing in Early Childhood Education: A Phenomenological Study
DOI: 10.6084/m9.figshare.22718437.v6
title: <b>Data for "</b><b>On the ice microphysics of isolated thunderstorms and non-thunderstorms in southern China: A radar polarimetric perspective</b><b>"</b>

description: In a manuscript entitled " <b>On the ice microphysics of isolated thunderstorms and non-thunderstorms in southern China: A radar polarimetric perspective</b><b> </b>". The data of our results are including in the Data_for_Fig_x.fig. These files can be opened by MATLAB R2020b(or later). The data supports the aforementioned manuscript and can be used freely for scientific purposes with appropriate citation.
DOI: 10.6084/m9.figshare.23708520.v1
title: GEE-CA data and code availability

description: This dataset supports the generation of figures and conclusions in the article "An online GEE-CA tool for seamlessly simulating global urban expansion with high resolutions". It includes simulated urban expansion from 2020 to 2050 under 5 SSP scenarios, projected urban demands, and other data for model performance analysis.
DOI: 10.6084/m9.figshare.24182106.v1
title: Supplementary Material for: Clinical application of confocal laser endomircoscopy combined with cryobiopsy in the diagnosis of interstitial lung disease

description: Background: Confocal laser endomicroscopy (CLE) has the characteristics of high resolution, real-time imaging and no radiation, which is helpful for the precise and effective implementation of transbronchial cryobiopsy (TBCB). Objectives: The study aimed to compare the efficacy and safety of TBCB combined with CLE (CLE group) or fluoroscopy (fluoroscopy group) in the diagnosis of interstitial lung disease (ILD). Method: From a prospective randomized controlled trial, eighty patients with undiagnosed ILD or ILD requiring biopsy between January 2022 and November 2022 were randomly assigned to CLE group and fluoroscopy group. The rate to reach an etiological diagnosis of ILD, maximum cross-sectional area of specimens, operation time and complications were compared between the two groups. Results: The rate to reach an etiological diagnosis in the CLE group was significantly higher than that in the fluoroscopy group (95.0% vs 80.0%, p&lt;0.05), but there was no difference in the maximum cross-sectional area of the specimens (42.1±10.1 mm2 vs 41.5±10.3 mm2, p&gt;0.05). In terms of operation time, the CLE group was significantly shorter than the fluoroscopy group (37.6±10.6 min vs 54.8±24.9 min, p&lt;0.05). The bleeding volume in the CLE group was significantly lower than that in the fluoroscopy group (4.9±3.6 ml/case vs 9.0±9.2 ml/case, p&lt;0.05). Further analysis showed that the incidence of moderate bleeding was also lower in the CLE group (20.0% vs 75.0%, p&lt;0.001). In addition, the incidence of pneumothorax in the CLE group was significantly lower than that in the fluoroscopy group (0 vs 25.0%, p&lt;0.001). Conclusions: Compared with simple fluoroscopy, the combination of CLE significantly improves the rate of etiological diagnosis, shortens the operation time, and reduces complications such as bleeding and pneumothorax.
DOI: 10.6084/m9.figshare.26503525.v2
title: Supplementary files for "Diversity and impact of single-stranded RNA viruses in Czech <i>Heterobasidion</i> populations" https://doi.org/10.1128/msystems.00506-24

description: <i>Heterobasidion annosum</i> sensu lato comprises some of the most devastating pathogens of conifers. Exploring virocontrol as a potential strategy to mitigate economic losses caused by these fungi holds promise for the future. In this study, we conducted a comprehensive screening for viruses in 98 <i>H. annosum</i> s.l. specimens from different regions of Czechia aiming to identify viruses inducing hypovirulence. Initial examination for dsRNA presence was followed by RNA-seq analyses using pooled RNA libraries constructed from <i>H. annosum</i> and<i> Heterobasidion parviporum</i>, with diverse bioinformatic pipelines employed for virus discovery. Our study uncovered 25 distinct ssRNA viruses, including two ourmia-like viruses, one mitovirus, one fusarivirus, one tobamo-like virus, one cogu-like virus, one bisegmented narna-like virus and one segment of another narna-like virus, and 17 ambi-like viruses, for which hairpin and hammerhead ribozymes were detected. Coinfections of up to 10 viruses were observed in six Heterobasidion isolates, whereas another six harbored a single virus. Seventy-three percent of the isolates analyzed by RNA-seq were virus-free. These findings show that the virome of Heterobasidion populations in Czechia is highly diverse and differs from that in the boreal region. We further investigated the host effects of certain identified viruses through comparisons of the mycelial growth rate and proteomic analyses and found that certain tested viruses caused growth reductions of up to 22% and significant alterations in the host proteome profile. Their intraspecific transmission rates ranged from 0% to 33%. Further studies are needed to fully understand the biocontrol potential of these viruses in planta.
DOI: 10.17633/rd.brunel.13191365.v1
title: Functional recovery in survivors of severe stroke dataset

description: The evidence on functional gains following rehabilitation in severe stroke survivors is unclear due to slow recovery and a perceived reduced potential to improve; this impacts on the provision of rehabilitation. There is limited research providing objective, temporal data on functional recovery after severe strokes. Hence, cohort study was conducted( as a part of a doctoral study) using prospective observational design where changes in functional abilities were investigated in a group of severe stroke survivors (NIHSS score &gt;10, MRS &gt;4 at admission).Patient outcomes over the first six months post-stroke were longitudinally measured using standardized, validated tools and statistically analysed.<br>This data set presents the anonymous raw data collected during the study. Ethical approval was obtained from the East Central Research Ethics Committee (Reference No: 16/EE/0072) prior to the commencement of the study.<br>Participants gave their consent to archive and publish anonymised data. <br>