cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.5241358.v1
title: Erratum: The Effect of Inactivated <i>Lactobacillus</i> LB Fermented Culture Medium on Symptom Severity: Observational Investigation in 297 Patients with Diarrhea-Predominant Irritable Bowel Syndrome

description: <i>Introduction:</i> Little is known about the intensity of symptoms of diarrhea-predominant IBS (IBS-D) or the consequences of the disease on patients’ health-related quality of life (HRQOL). This observational investigation assessed the symptoms (abdominal pain, bloating, number of stools per day, and stool consistency), impact on HRQOL, and consequence on anal continence in 297 patients with IBS-D before and after 1 month of probiotic treatment with Lacteol (inactivated <i>Lactobacillus </i>LB plus fermented culture medium). <i>Methods:</i> Functional assessment using a standardized visual analogue scale in order to quantify abdominal pain, bloating, and quality of life before and after 1 month of treatment with 2 capsules/day of Lacteol. The number of symptomatic days per week, number of stools, consistency of stools, secondary fecal incontinence rate, and potential trigger effect of food were quantified. A χ<sup>2</sup> test was used to compare qualitative data and the variance of quantitative criteria was analyzed. <i>Results:</i> The pain score decreased from 4.46 ± 0.15 on a scale of 0–10 before treatment to 2.8 ± 0.14 after treatment (p &lt; 0.0001). Bloating decreased from 4.49 ± 0.18 to 2.5 ± 0.15 on a scale of 0–10 (p &lt; 0.0001). The HRQOL score, which is inversely correlated with quality of life, decreased from 5.99 ± 0.14 to 3.92 ± 0.16 (p &lt; 0.0001). In this cohort study, the fecal incontinence rate secondary to diarrhea was clearly higher than that of the general population: 18% versus a prevalence of 9–10%, according to different studies. The mean number of stools per week decreased from 17.59 to 12.83 after treatment (p &lt; 0.0001). Before treatment, 54% of patients had watery stools and 46% had smooth stools; at the end of treatment, only 18.5% of patients still had watery stools, and 34% had normal stools. 52% of patients attributed their symptoms to their diet: 34% to vegetables, 29% to fruit, 15% to milk, 15% to fat, 6% to peppers and spices, and 4% to sugar. <i>Conclusion:</i> This observational investigation shed new light on patients with IBS-D, the HRQOL of which is altered by a fecal incontinence rate twice as high as that of the general population. Correlation with diet is confirmed by 1 out of 2 patients reporting poor tolerance of fiber and dairy products. Nutritional management should thus be part of these patients’ treatment. Inactivated <i>Lactobacillus</i> LB plus fermented culture medium is a probiotic drug that has been used by physicians for a long time to treat patients with diarrhea. Strongly concentrated, it has no side effects and seems to help these patients. Due to a strong placebo effect in patients with this pathology, however, a controlled study is necessary to confirm this result.
DOI: 10.6084/m9.figshare.7177589.v1
title: Supplementary Material for: Cell-Free DNA and Neuromediators in Detecting Aggressive Variant Prostate Cancer

description: <b><i>Background:</i></b> Aggressive variant transformation in metastatic castration-resistant prostate cancer (mCRPC) represents an under-recognized phenomenon. There is an urgent need for non-invasive biomarkers to detect these variants and identify treatment alternatives. <b><i>Methods:</i></b> A prospective observational pilot study in mCRPC patients receiving treatment with cabazitaxel (CAB) was conducted. Neuromediators were sequentially evaluated and their impact on disease endpoints calculated. Targeted next-generation sequencing (NGS) of cell-free DNA (cfDNA) was also performed in a highly pretreated subset of patients. <b><i>Results:</i></b> 23 patients were included. Estimated effects indicate that neuron-specific enolase (NSE) levels at baseline may be correlated with overall survival (NSE unit 18.3 ng/ml: HR1.262 (95% confidence interval (CI) 0.985-1.616)) and that chromogranin A (CGA) may be correlated with progression-free survival (CGA unit 98.1 ng/ml: HR1.341 (95% CI 1.011-1.778)). cfDNA analysis revealed mutations annotated in prostate cancer (PCA) and small cell cancers (SCC). 1 patient showed elevated neuromediators along with annotated mutations in PCA and SCC, potentially indicating aggressive variant cancer. In 3 patients KIT mutations (e.g. pM541L, pV654A) known to be tissue-based biomarkers with level 1 evidence for the treatment with imatinib and sunitinib were found. <b><i>Conclusions:</i></b> Sequential analysis of neuromediators and targeted NGS of cfDNA provide insight for the estimation of tumor heterogeneity under therapy with CAB.
DOI: 10.6084/m9.figshare.26400157.v1
title: RPM Ascl1 KO SQ tumor associated mIF files. Transplanted into intact host.

description: RPM SQ tumor associated mIF files. Transplanted into intact host.
DOI: 10.6084/m9.figshare.28022435.v1
title: Supplementary Material for: Vasoproliferative Retinal Tumors – Manifestations, Management, and Outcomes in a Case Series

description: Introduction:
Vasoproliferative retinal tumors (VPRTs) are rare, benign retinal lesions characterized by abnormal vascular proliferation. They may appear sporadically or with systemic conditions like von Hippel-Lindau disease, often resembling other retinal lesions and posing diagnostic challenges. VPRTs can lead to vision loss if not adequately managed. Current management ranges from observation to different treatment strategies, from laser photocoagulation, photodynamic therapy, cryotherapy to intravitreal injections and vitrectomy. However, optimal approach is still debated due to VPRTs’ rarity and varied presentations.
Case Presentations:
This series presents three VPRT cases. The first, a 73-year-old man who presented with sudden vision loss due to a VPRT-related vitreous hemorrhage, required multiple interventions, including vitrectomies and anti-VEGF injections, but suffered recurrent macular edema and glaucoma, requiring ongoing management. The second, a 42-year-old asymptomatic man, showed lipid exudation and peripheral retinal detachment, needing photodynamic therapy, laser, and cryotherapy. The third, a 56-year-old woman with decreased visual acuity and epiretinal membrane, achieved stability and good visual outcomes after vitrectomy with cryotherapy.
Conclusions:
VPRTs pose diagnostic and therapeutic challenges given their heterogeneous presentations and potential for complications. Our cases illustrate that a multimodal management strategy—incorporating tailored combinations of therapies such as laser photocoagulation, cryotherapy, anti-VEGF injections, and surgery—is essential to address individual characteristics of each patient’s disease. Personalized treatment approaches allow for precise targeting of the lesions while minimizing risk of complications, contributing to better disease stabilization and visual outcomes. Early detection and tailored management are essential, though further research is needed to establish standardized treatment protocols.
DOI: 10.6084/m9.figshare.12081624.v1
title: SPSS master file

description: Full data set saved as an SPSS data file and Excel file. Raw data from all
DOI: 10.6084/m9.figshare.5425546.v1
title: China national energy inventory, 2000-2015

description: The dataset provides China national energy inventory from 2000-2015.Raw data are collect from China energy statistical yearbooks 2014-2016
DOI: 10.6084/m9.figshare.16823164.v1
title: Tweets analysis

description: in our study, we performed different analysis such as sentiment analysis on the tweets posted by the visitors of the most popular European museums before and after Covid-19 pandemic in order to understand how emotional responses of the users who are interested in art has changed by this global crisis. <br>
DOI: 10.6084/m9.figshare.26410651.v1
title: Supplementary Material for: Accelerated linear growth during Erdafitinib treatment: An FGFR related, but growth factor and sex steroid independent mechanism?

description: Introduction:
Growth acceleration during postnatal growth only occurs during puberty as a physiological event and during catch-up growth mediated by growth promoting therapies in growth disorders. Here we report on novel observations on skeletal symptoms during treatment with Erdafitinib, a tyrosine kinase inhibitor (TKI) prescribed on the basis of a compassionate-use program.

Methods:
Analysis of anthropometric, biochemical, clinical and radiographic data of patients with CNS tumors who revealed an unanticipated growth spurt with initiation of therapy with Erdafitinib was performed retrospectively.

Results:
Linear growth acceleration was independent of sex steroids and IGF1 levels, which is especially remarkable in the context of heavily pretreated pediatric neuro-oncology patients with severe growth impairment before initiation of therapy. Growth acceleration was accompanied by distinct widening of the growth plate and enhanced metaphyseal mineralization shortly after the start of TKI therapy.

Conclusions:
While targeted therapies including TKIs have become an essential part in adult cancer treatment, applications in children are still limited. Off-target effects specific to the pediatric population have been observed in various organ systems, however knowledge about the effect of TKIs on the growing skeleton is scarce. As treatment with Erdafitinib inhibits FGFR3-mediated effects and thus represents a very logical hypothetical framework of growth factor and sex steroid independent growth acceleration.
DOI: 10.6084/m9.figshare.28737881.v1
title: image-shenyang(1).7z

description: Shenyang Image
DOI: 10.6084/m9.figshare.24547363.v2
title: Chinese asset managers’ WACI inventories, 2010-2020.xlsx

description: 105 are for asset managers’ WACI inventory (2010-2020）
DOI: 10.6084/m9.figshare.24679656.v1
title: Curated Email-Based Code Reviews Datasets

description: Code review is an important practice that improves the overall quality of a proposed patch (i.e. code changes). While much research focused on tool-based code reviews (e.g. a Gerrit code review tool, GitHub), many traditional open-source software (OSS) projects still conduct code reviews through emails. However, due to the nature of unstructured email-based data, it can be challenging to mine email-based code reviews, hindering researchers from delving into the code review practice of such long-standing OSS projects. Therefore, this paper presents large-scale datasets of email-based code reviews of 167 projects across three OSS communities (i.e. Linux Kernel, OzLabs, and FFmpeg). We mined the data from Patchwork, a web-based patch-tracking system for email-based code review, and curated the data by grouping a submitted patch and its revised versions and grouping email aliases. Our datasets include a total of 4.2M patches with 2.1M patch groups and 169K email addresses belonging to 141K individuals. Our published artefacts include the datasets as well as a tool suite to crawl, curate, and store Patchwork data. With our datasets, future work can directly delve into an email-based code review practice of large OSS projects without additional effort in data collection and curation.
DOI: 10.6084/m9.figshare.4234280.v4
title: ebola.spillover.intensity.final

description: R workspace (set of data), raster datasets, and code used to generate spatiotemporal triggers of Ebola across Africa and figures in the article.<br>
DOI: 10.6084/m9.figshare.25108205.v1
title: Vector analysis of corneal astigmatism in cataractous eyes based in IOLMaster 700 biometry - PlosONE

description: This minimal dataset is used to retrieve the results presented in PlosONE PONE-D-23-32750
DOI: 10.6084/m9.figshare.28520267.v1
title: CESM2-WACCM IVT

description: CESM2-WACCM IVT
DOI: 10.6084/m9.figshare.9276710.v1
title: Low back pain at the third age: distribution and prevalence at the Physical Therapy School Clinic from the Southwestern Bahia State University, Brazil

description: Abstract The degeneration of the spine inherent in the aging process, along with the higher length of exposure to burdens through life, may cause a tendency of the elderly to suffer from low back pain. Therefore, this study is aimed at determining the prevalence and characterization of low back pain on elderly attended in the geriatrics sector of the Physical Therapy School Clinic from the Universidade Estadual do Sudoeste da Bahia. It's a descriptive, cross-sectional study accomplished through research of 44 records of patients who suffered from low back pain, aged 60 or more, from both sexes, among 131 records of elderly, with a prevalence of 33.6%. The subjects were mainly women, belonging to age group of 60 to 69 years, and retired. It was verified that 21 (47.73%) of the elderly had low back pain of unknown origin; 19 (43.18%), chronic pain, and 26 (59.09%), irradiation to the lower extremity. Through this study, a high prevalence of low back pain in elderly people was found, and it is an important data to precocious intervention and prevention, so as to improve the quality of life of this population. for institutionalization.
DOI: 10.6084/m9.figshare.16692229.v4
title: Datasets of "Population connectivity and seascape genomics of Paramuricea biscaya in the northern Gulf of Mexico"

description: Raw<i> </i>SNP dataset (vcftools): filtered_paramuricea_variants_70_123.recode.vcf<i>all_snp </i>SNP dataset (GENIND OBJECT): loci.individuals.het_all.Rneutral SNP dataset (GENIND OBJECT): loci.individuals.neutral_biallelic.RMatrix of environmental variables and individual sampling information (tsv): EnvMatrix_ind.tsv<br><br>
DOI: 10.6084/m9.figshare.27118422.v2
title: QUIC-seq Data

description: <b>This item contains QUIC-seq sequencing data, </b><b>The BAM files generated from RNA-seq data, based on QUIC-seq and TruSeq, aligned to the maize genome.</b><br><i>Please note that the BAM files from QUIC-seq are deduplicated, while the BAM files from TruSeq have not been deduplicated.</i><br><i>QUICseq.fq.gz </i>and <i>TruSeq.fq.gz </i>are used to compare the relevance of the two techniques;<br><i>QUICseq.fq.gz </i>and <i>QUICseq_repeat.fq.gz</i> for comparing QUIC-seq repeatability;<br><i>At.fq.gz, Os.fq.gz</i> and <i>Zm.fq.gz</i> were used to test the level of contamination between samples from the mixed library;<br><i>quan1n.fq.gz, quan2n.fq.gz, quan3n.fq.gz, que1n.fq.gz, que2n.fq.gz,</i> and <i>que3n.fq.gz</i> are used for the nutrient deficiency experiment with N, P, and K deficiencies. In these file names, "quan" represents the control group, "que" represents the treatment group, and "1n," "2n," and "3n" correspond to replicates 1, 2, and 3, respectively.<br><br>The prefixes "Bst," "SDS," and "Inactivation" represent different steps omitted during the library preparation optimization. For each group, the first three data points (1, 2, 3) correspond to the control group, where the step is not omitted, while the last three data points (4, 5, 6) represent the treatment group, where the step is omitted.<br>
DOI: 10.6084/m9.figshare.7195067.v1
title: Supplementary Material for: Shufeng Jiedu Capsules Alleviate Lipopolysaccharide-Induced Acute Lung Inflammatory Injury via Activation of GPR18 by Verbenalin

description: <b><i>Background/Aims:</i></b> Acute respiratory tract infection (ARTI) is the most common reason for outpatient physician office visits. Although powerful and significant in the treatment of infections, antibiotics used for ARTI inappropriately have been an important contributor to antibiotic resistance. We previously reported that Shufeng Jiedu Capsule (SJC) can effectively amplify anti-inflammatory signaling during infection. In this study, we aimed to systematically explore its composition and the mechanism of its effects in ARTI. <b><i>Methods:</i></b> <i>Pseudomonas aeruginosa</i> (PAK) strain was used to generate a mouse model of ARTI, which were then treated with different drugs or compounds to determine the corresponding anti-inflammatory roles. High-performance liquid chromatography-quadrupole time of flight-tandem mass spectrometry. was conducted to detect the chemical compounds in SJC. RNAs from the lung tissues of mice were prepared for microarray analysis to reveal globally altered genes and the pathways involved after SJC treatment. <b><i>Results:</i></b> SJC significantly inhibited the expression and secretion of inflammatory factors from PAK-induced mouse lung tissues or lipopolysaccharide-induced peritoneal macrophages. Verbenalin, one of the bioactive compounds identified in SJC, also showed notable anti-inflammatory effects. Microarray data revealed numerous differentially expressed genes among the different treatment groups; here, we focused on studying the role of GPR18. We found that the anti-inflammatory role of verbenalin was attenuated in GPR18 knockout mice compared with wild-type mice, although no statistically significant difference was observed in the untreated PAK-induced mice types. <b><i>Conclusion:</i></b> Our data not only showed the chemical composition of SJC, but also demonstrated that verbenalin was a significant anti-inflammatory compound, which may function through GPR18.
DOI: 10.6084/m9.figshare.7330244.v1
title: Human Convalescent Serum Sample after DENV3 seroconversion.

description: Human Convalescent Serum Sample collected after DENV3 seroconversion.
DOI: 10.17632/984bcsp4yt
title: 维生素A儿科数据

description: 记录了基础数据，维生素浓度，膳食数据
DOI: 10.6084/m9.figshare.6096986.v1
title: Twitterstorm data: the Katie Hinde Target t-shirt saga 2017-06-11

description: This repository contains data from the Twitterstorm that occurred from June 11-13 2017 following a controversial tweet by scientist and public figure Katie Hinde (@Mammals_Suck on Twitter). This is a good dataset for practicing the analysis of text and/or social network data in R. <br><br>1. <b>tweets_raw.Rds </b>contains raw text data for all 33261 tweets mentioning @Mammals_Suck in the 36 hours following the original tweet. This file can be read into R using the 'readRDS' function.<br><br>2.<b> tweets_clean.csv </b>contains clean data on all 4843 quote & reply tweets responding to the original tweet over a 36 hour period, including: tweet text, user name, tweet time, # of favorites, # of retweets, # of friends of the user, # of followers of the user, user self-description, user location, type (quote or reply).<br><br>3. <b>social_network.rds </b>contains a social network for users in the twitterstorm an an 'igraph' object. Vertex names correspond to Twitter users, and edge weights are based on co-followers (i.e., the number of mutually followed accounts, which is a proxy for overlap in the interests of two users). Additional vertex attributes can be added to the graph using information about users from the 'tweets_clean.csv' file, such as the time they entered the twitterstorm, their geographic location, or the text content of their tweets. This file can be read into R using the 'readRDS' function. <br><br>For more information, check out the blog posts written by myself and Katie Hinde. Mine focuses on data analysis, while hers focuses on her experience and understanding of the events. <br><br><b>My blog post:</b> https://rgriff23.github.io/2017/06/29/Katie-Hinde-Twitterstorm.html <br><br><b>Katie Hinde's blog post:</b> https://mammalssuck.blogspot.co.uk/2017/06/portrait-of-unexpected-twitter-storm.html <br><br>The R code I used to compile and analyze this data can be found in this GitHub repository: https://github.com/rgriff23/Katie_Hinde_Twitter_storm_text_analysis<br><br>Note that the data in the GitHub repo does not match the data included in this figshare repo exactly. This is because the data provided here has been reduced to information collected from Twitter: I eliminated data columns that were produced using subsequent analysis, such as tweet classifications based on sentiment analysis or social network analysis. <br>
DOI: 10.17632/zjhjmrz4vh
title: Comparison of ultrasound signs, computed tomography data and morphological examination of the lungs in patients with coronavirus infection: post hoc analysis

description: INTRODUCTION: Ultrasound examination (US) of the lungs has shown high efficiency in the diagnosis of COVID-19 pneumonia. The aim of the research was studying the correspondence of computed tomography (CT) US signs of the lungs and morphological data in patients with COVID-19 pneumonia. 
MATERIALS AND METHODS. The post hoc analysis included 388 patients who simultaneously underwent ultrasound and CT of the lungs. Lung ultrasound was performed according to the 16-zone "Russian Protocol". Morphological data were obtained from the results of pathoanatomic examination of deceased patients. 
RESULTS. The comparison of signs detected by CT and ultrasound of the lungs was performed during a multidimensional correspondence analysis. The analysis was carried out using a three-dimensional solution that explained 64.9% of inertia (p<0.001). CT signs of "ground glass opacity" (100%) corresponded to the B line at ultrasound (100%); CT of the consolidation sign (44.8%) – ultrasound signs of consolidation (46.9%); aerobronchogram of CT (34%) – aerobronchogram of ultrasound (36.9%); free liquid CT (11.1%) – free liquid Ultrasound (13.9%). CT signs of reticular changes (29.6%) and "cobblestone pavement" (12.4%) corresponded to various combinations of ultrasound signs of subpleural consolidation and B-lines.
The B-lines were caused by the exudation of fluid and protein molecules into the intraalveolar space against the background of massive death of alveolocytes and formed by the development of intraalveolar edema and the formation of hyaline membranes. The ultrasonic sign of consolidation appeared in the airless zone of the lungs. Subpleural consolidation are caused by thickening and inflammatory infiltration of the pleura, diffuse alveolar damage, with intraalveolar edema, death and decay of alveolocytes, perivascular inflammatory cell reaction/ During treatment for more than 7 days, consolidation in the lung tissue developed due to the disorganization of the organ structure due to the progression of fibrosis.
CONCLUSION. Multivariate correspondence analysis showed correlation of CT signs and US signs of the lungs. Morphological analysis showed polymorphism of histological data that caused the formation of ultrasound signs.
DOI: 10.6084/m9.figshare.19544410.v1
title: Synthetic HIV Dataset

description: Synthetic HIV dataset generated using the Health Gym GAN.
DOI: 10.6084/m9.figshare.21586344.v1
title: Supplementary Table 1_SourceData for Figure 3

description: Here we provide the Data Source file for generating Figure 3 for our review. <strong>Extracellular matrix dynamics as an emerging yet understudied hallmark of aging and longevity</strong> Cyril Statzer, Ji Young Cecilia Park, and Collin Y. Ewald Aging and Disease http://dx.doi.org/10.14336/AD.2022.1116