cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.18393950.v1
title: Supplementary Material for: Real-World Data for Lenvatinib in Hepatocellular Carcinoma (ELEVATOR): A retrospective multicenter study

description: Background Lenvatinib is approved as first-line treatment for patients with advanced hepatocellular carcinoma (HCC). The efficacy of lenvatinib in Caucasian real-world patients is insufficiently defined. The purpose of this study was to evaluate the efficacy of lenvatinib in a multi-center cohort (ELEVATOR) from Germany and Austria. Methods A retrospective data analysis of 205 patients treated with first-line systemic lenvatinib at 14 different sites was conducted. Overall survival, progression free survival, overall response rate and adverse event rates were assessed and analyzed. Results Patients receiving lenvatinib in the real-world setting reached a median overall survival of 12.8 months, which was comparable to the results reported from the REFLECT study. Median overall survival (mOS) and progression free survival (mPFS) was superior in those patients who met the inclusion criteria of the REFLECT study compared to patients who failed to meet the inclusion criteria (mOS 15.6 vs 10.2 months, HR 0.55, 95% CI 0.38-0.81, p=0.002; mPFS 8.1 vs 4.8 months HR 0.65, 95% CI 0.46-0.91, p=0.0015). For patients with an impaired liver function according to the Albumin-Bilirubin (ALBI) grade, or reduced ECOG performance status ≥2, survival was significantly shorter compared to patients with sustained liver function (ALBI grade 1) and good performance status (ECOG performance status 0), respectively (HR 1.69, 95% CI 1.07-2.66, p=0.023; HR 2.25, 95% CI 1.19-4.23, p=0.012). Additionally, macrovascular invasion (HR 1.55, 95% CI 1.02-2.37, p=0.041) and an AFP ≥200 ng/mL (HR 1.56, 95% CI 1.03-2.34, p=0.034) were confirmed as independent negative prognostic factors in our cohort of patients with advanced HCC. Conclusion Overall, our data confirm the efficacy of lenvatinib as first-line treatment and did not reveal new or unexpected side effects in a large retrospective Caucasian real-world cohort, supporting the use of lenvatinib as meaningful alternative for patients that cannot be treated with IO-based combinations in first-line HCC.
DOI: 10.6084/m9.figshare.1125341.v1
title: PTSD & depression amongst survivors of a Bangladesh garment factory collapse_Survey

description: Survey data for "Post-traumatic stress disorder and depression amongst survivors of a Bangladesh garment factory collapse," by Megan Mueller, MPH, Manirul Islam, MBBS, MCPS, DPH, MMedSc, PhD, and M. Sophia Newman, MPH. Mental health system development increases in the aftermath of disasters, but there is a paucity of data on post-disaster mental health in Bangladesh. We assessed the mental health of workers who survived the collapse of Rana Plaza, a nine-story factory in Savar, Bangladesh, on April 24, 2013. Via a cross-sectional observational study method, we collected data from 290 participants, and a psychiatrist completed a diagnostic assessment with 74 of these. Please see data in first tab of Excel workbook and data dictionary and codebooks in subsequent tabs.
DOI: 10.6084/m9.figshare.5126143.v1
title: Supplementary Material for: Postnatal and Adult Immunoglobulin Repertoires of Innate-Like CD19<sup>+</sup>CD45R<sup>lo</sup> B Cells

description: The diversity in antibody repertoire relies on different B cell populations working efficiently to fulfil distinct specific functions. We recently described an innate-like CD19<sup>+</sup>CD45R<sup>-/lo</sup> (19<sup>+</sup>45R<sup>lo</sup>) cell population in postnatal unstimulated adult mice, a heterogeneous population containing cells expressing immunoglobulin M (IgM) and others behaving as differentiated mature B lymphocytes (intracytoplasmic IgG1, AID<sup>+</sup>, Blimp-1<sup>+</sup>RAG2<sup>-</sup>). In the present study, we characterized the Ig repertoire expressed by splenic 19<sup>+</sup>45R<sup>lo</sup> cells, assuming that they would bear a restricted repertoire biased for germline rearrangements and low mutation rates similar to other innate-like cells. Sequences from 19<sup>+</sup>45R<sup>lo</sup> cells displayed a variety of V, D and J regions, and the analysis of the CDR-H3 region revealed an intermediate overall CDR-H3 length and moderate hydrophobicity. Both IgM and switched sequences of PD15 19<sup>+</sup>45R<sup>lo</sup> cells had shorter CDR-H3 region and fewer non-template N nucleotides than adult sequences, as expected for profiles that correspond to an immature phenotype. Regarding the mutation rate in the VH regions, IgG1 sequences already carried a high rate of replacement mutations at PD15, which increased further in the sequences obtained from adult mice. Moreover, statistical models suggest that a proportion of the switched sequences in adult 19<sup>+</sup>45R<sup>lo</sup> cells had experienced antigen selection, unlike other innate-like B cell compartments.
DOI: 10.17632/jm4j25hdh3
title: Nicory_2019_goat_MinasFrescal_cheese

description: PHD Thesis from Isis Miranda Carvalho Nicory - Goat Minas Frescal cheese analyses
DOI: 10.17632/chhv8493f7
title: Who Is Imam Mahdi, Prophesied In Other Religions, And From Holy Fatima lineage?

description: Purpose: In this article, we will discuss the narrations and prophecies that exist in Islam, both in Shia, Sunni and other religions regarding Imam Mahdi. This article also attempts to deal with Holy Fatima and her characteristics. Also, we will show that Imam Mahdi is mentioned not only in other religions but also in other books. Also, this research was conducted to answer and clarify three questions that stated in the Introduction section.
Methods: We performed our methods in 4 stages: Identifying studies, Selection of Studies, Collating Studies, Reporting results.
Results: According to Abrahamic religions, a person will reappear and establish fairness and justice with the help of God, who is called Imam Mahdi and based on the opinion of Christians, he is Christ. If the Shiites, may Allah help them in His obedience, had fulfilled their covenant with united hearts, then there would have been no delay in meeting the Promised Saviour. 
Conclusion: The concept of Imam Mahdi is universal and cannot just be rejected. The appearance of Imam Mahdi will coincide with the coming back of Jesus Christ. Imam Mahdi, with the assistance of the Messiah, will ensure the completion and practical actualization of the mission of the Prophet Muhammad. The Hidden Imam wrote to Abu-Omar Ameri: The Prophet’s daughter (Holy Fatima) is a nice model for me. We hope this article will take an important step in acquainting people with Imam Mahdi and Jesus Christ and paving the ground for their reappearance.
DOI: 10.6084/m9.figshare.12423596.v3
title: Clinical_isolate_data

description: Clinical isolate metadata<br>
DOI: 10.6084/m9.figshare.28078913.v2
title: Correlation between Posterior Teeth Loss and Temporomandibular Joint Disorder Symptoms in Adult Patients

description: The relationship between TMD and loss of posterior teeth is still a subject of continuous discussion and remains a controversial issue. The present study aimed to find a correlation between posterior teeth loss and TMJ disorder symptoms in adult patients
DOI: 10.6084/m9.figshare.27221169.v2
title: STRO 1.0 - Legacy Data from Sound Toll Registers Online (version 2021.12.29)

description: This project contains a legacy copy of data that was available at Sound Toll Registers Online (www.soundtoll.nl) until 2024.07.02. Sound Toll Registers Online does not keep track of changes made to the data they offer for download. Since changes are not documented on the website, scripts prepared for one version of the data may results in errors when applied to a newer version. For the purpose of documentation, the legacy data of STRO 1.0 (i.e. the original version that was published on 2021.12.29) is made available here. These files were used to create STRO 2.0 (another project on figshare).
DOI: 10.17632/xn9ws8x6j7
title: The Economic Bomb: A Strategic Financial Warfare Tactic

description: This dataset provides evidence supporting the hypothesis that institutional shorting, ETF outflows, whale wallet movements, and media sentiment drive Bitcoin’s volatility and price manipulation. Central to this dataset is the Decker Sentiment-Short Interest Model (DSSIM)—an original equation developed by Nicolin Decker to quantify the relationship between market sentiment and institutional short interest. By combining sentiment scores from Natural Language Processing (NLP) and short positioning data, DSSIM offers a flexible framework for analyzing volatility in Bitcoin and other assets.

The dataset spans January 2021 to December 2024, capturing daily market activity and key price events. Each file aligns with DSSIM’s variables, enabling replication and further analysis of the findings in the doctoral-level thesis The Economic Bomb: A Strategic Financial Warfare Tactic.

Key Components:
BTC_Price_Data.csv: Daily BTC/USD closing prices from Binance, Coinbase, and Bitstamp, serving as the baseline for volatility and return calculations.

ETF_Holdings_Over_Time_Thesis.csv: Daily BTC holdings of ETFs (Grayscale, BlackRock, and Fidelity), illustrating cumulative outflows and their liquidity impact.

ETF_Outflows_Price_Impact_Data.csv: Correlates ETF outflows with BTC volatility, highlighting timing and magnitude.

Institutional_Shorting_Data.csv: Daily BTC short positions from Binance, BitMEX, Bybit, and OKX, serving as input for DSSIM’s short interest variable.

Whale_Wallet_Movements.csv: Tracks large BTC wallet movements, revealing sell-offs preceding price crashes and influencing DSSIM’s residual noise component.

Market_Liquidity_Data.csv: Daily BTC trading volume, order book depth, and liquidity ratios, validating DSSIM’s predictive capabilities.

Media_Sentiment_Scores.csv: Daily sentiment from Twitter, Reddit, Google News, and YouTube, forming DSSIM’s sentiment variable.

Monte_Carlo_Simulation_Results.csv: Simulates 1,000 BTC price paths to assess potential volatility under market stress.

VAR_Model_Data.csv: Analyzes ETF outflows’ delayed impact on BTC returns using vector autoregression.

Volatility_Clustering_Data.csv: Tracks daily BTC returns and 30-day rolling volatility, confirming persistent volatility after institutional actions.

GARCH_Model_Data.csv: Models BTC volatility using GARCH, validating volatility clustering during market shocks.

The dataset includes adjustments for major market events, such as the May 2021 Flash Crash, June 2022 Liquidation Crisis, and March 2023 Banking Crisis, ensuring realistic volatility patterns aligned with DSSIM’s modeling of sentiment shifts and institutional shorting.

Researchers can use DSSIM’s structure and data to explore similar dynamics in other cryptocurrencies, equities, commodities, and forex markets, advancing financial analysis and predictive modeling.

Access the full dataset: 
https://drive.google.com/drive/folders/1pnwqBTMF_QSJoC5QcNAPSQpVtOST2n8c?usp=drive_link
DOI: 10.17632/zktjjx93sv
title: Health literacy data

description: This data is about cross-culturally adapting the short 16-item version of HLS-EU and assessing the psychometric properties of both the 16- and 6-item versions.
DOI: 10.6084/m9.figshare.28643633.v1
title: <b>DuoOpti-YOLO: Enhanced Multi-Scale Erosion Detection in GFRP Strips via Dual-Layer Channel Optimization</b>

description: DuoOpti-YOLO：通过双层通道优化数据样本，以增强 GFRP 条带中的多尺度侵蚀检测
DOI: 10.17632/pp388fh65j
title: Incidence of hair loss concerns in women who wear the hijab: An exploratory survey

description: The hijab is a religious head-covering worn by many Muslim women around the world from various cultural and racial backgrounds. Although approximately 40% of American Muslim women wear the hijab, there is a gap in the literature regarding hair loss amongst women who wear the hijab. The current study aims to understand the hijab wearing practices of Muslim women and identify factors that could contribute to hair loss to better address the concerns of women who wear the hijab and provide future interventions. An online survey was developed and distributed to women who wear the hijab through mosque email lists, group chats, and social media through RedCap. The inclusion criteria were women who wear the hijab, are over the age of 18, and who reside in the United States.
DOI: 10.6084/m9.figshare.13286090.v1
title: Supplementary Material for: Circulating Levels of Dickkopf-Related Protein 1 Decrease as Measured GFR Declines and Are Associated with PTH Levels

description: <b><i>Background:</i></b> The Wnt/β-catenin pathway has been implicated in the development of adynamic bone disease in early-stage chronic kidney disease (CKD). Dickkopf-related protein 1 (DKK1) and sclerostin are antagonists of the Wnt/β-catenin pathway yet have not been widely used as clinical indicators of bone disease. This study characterized levels of DKK1, sclerostin, and other biomarkers of mineral metabolism in participants across a spectrum of inulin-measured glomerular filtration rate (GFR). <b><i>Methods:</i></b> GFR was measured by urinary inulin clearance (mGFR) in 90 participants. Blood samples were obtained for measurement of circulating DKK1, sclerostin, fibroblast growth factor 23 (FGF-23), parathyroid hormone (PTH), calcium, phosphate, α-klotho, and vitamin D metabolites including 25-hydroxyvitamin D<sub>3</sub> and 1,25-dihydroxyvitamin D<sub>3</sub>. Spearman correlations and linear regressions were used where appropriate to examine the associations between measured values. <b><i>Results:</i></b> The median [IQR] age was 64 years [53.0–71.0], and the median [IQR] mGFR was 32.6 [21.7–60.6] mL/min. DKK1 decreased (<i>r</i> = 0.6, <i>p</i> &lt; 0.001) and sclerostin increased (<i>r</i> = −0.4, <i>p</i> &lt; 0.001) as kidney function declined, and both were associated with phosphate, PTH, FGF-23, and 1,25-dihydroxyvitamin D<sub>3</sub> in the unadjusted analysis. After adjustment for age and mGFR, DKK1 remained significantly associated with PTH. <b><i>Conclusion:</i></b> The results of this study demonstrate opposing trends in Wnt/β-catenin pathway inhibitors, DKK1 and sclerostin, as mGFR declines. Unlike sclerostin, DKK1 levels decreased significantly as mGFR declined and was independently associated with PTH. Future studies should determine whether measurement of Wnt signaling inhibitors may be useful in predicting bone histomorphometric findings and important clinical outcomes in patients with CKD.
DOI: 10.6084/m9.figshare.28182167.v1
title: Supplementary Material for: Efficacy and safety of GutGard® in managing gastro-esophageal reflux (GER)-related symptoms - A Phase III, single centre, double-blind, randomized placebo-controlled trial

description: Introduction: Liquorice (Glycyrrhiza glabra) is a traditional herbal remedy with various pharmacological activities mainly used for digestive and respiratory ailments. GutGard® is a flavonoid-rich, deglycyrrhinizated liquorice root extract and is standardized to glabridin (≥3.5% w/w), glabrol (≥0.5% w/w), eicosanyl caffeate (≥0.1% w/w), docosyl caffeate (≥0.1% w/w) and total flavonoids (≥10% w/w) with glycyrrhizin (≤0.5% w/w) as glycyrrhizin causes electrolyte imbalance, hypertension and water retention. . Hence, the objective of the current study was to assess the efficacy, safety and tolerability of GutGard® in managing gastro-esophageal reflux (GER) related symptoms when compared to placebo. 
Methods: It was a double blind, parallel group, randomized, placebo-controlled trial with participants randomized in a 1:1 ratio to either the placebo group or GutGard® group. The duration of the interventions/treatment was for 28 days and the follow-up visits were done at day-7, day-14, day-28 and day-35. A telephonic follow-up was also done on day-21. The primary outcome measures studied was the change in the Gastroesophageal Reflux Disease – Health Related Quality of Life (GERD- HRQL) and the Gastroesophageal Reflux Disease Symptom Assessment Scale (GSAS). 
Results: We screened a total of n=296 participants and enrolled n=200 participants and obtained written, informed consent from them. Participants in the GutGard® group reported a significantly better quality of life at the end of the intervention period (p = 0.014). They also reported earlier resolution of symptoms of GER as against the placebo group especially the symptoms of heartburn (p = 0.017 on day-14 and p = 0.005 on day-28) and regurgitation (p = 0. 025 on day-7, p = 0.029 on day-14 and p = 0.022 on day-28). 
Conclusions: The GutGard® group showed better and earlier resolution (within two weeks) of symptoms of GER as against the placebo group especially heartburn and regurgitation.
DOI: 10.17632/xscj6vnkkw
title: PM2D: A parallel GPU-based code for the kinetic simulation of laser plasma instabilities at large scales

description: Laser plasma instabilities (LPIs) have significant influences on the laser energy deposition efficiency and therefore are important processes in inertial confined fusion (ICF). Numerical simulations play important roles in revealing the complex physics of LPIs. Since LPIs are typically a three wave coupling process, the precise simulations of LPIs with kinetic effects require to resolve the laser period (around one femtosecond) and laser wavelength (less than one micron). In the typical ICF experiments, however, LPIs are involved in a spatial scale of several millimeters and a temporal scale of several nanoseconds. Therefore, the precise kinetic simulations of LPIs in such scales require huge computational resources and are hard to be carried out by present kinetic codes like particle-in-cell (PIC) codes. In this paper, a full wave fluid model of LPIs is constructed and numerically solved by the particle-mesh method, where the plasma is described by macro particles that can move across the mesh grids freely. Based upon this model, a two-dimensional (2D) GPU code named PM2D is developed. The PM2D code can simulate the kinetic effects of LPIs self-consistently as normal PIC codes. Moreover, as the physical model adopted in the PM2D code is specifically constructed for LPIs, the required macro particles per grid in the simulations can be largely reduced and thus overall simulation cost is considerably reduced comparing with PIC codes. More importantly, the numerical noise in the PM2D code is much lower, which makes it more robust than PIC codes in the simulation of LPIs for the long-time scale above 10 picoseconds. After the distributed computing is realized, our PM2D code is able to run on GPU clusters with a total mesh grids up to several billions, which meets the requirements for the simulations of LPIs at ICF experimental scale with reasonable cost.
DOI: 10.15468/dl.yf25jk
title: Occurrence Download

description: A dataset containing 155 species occurrences available in GBIF matching the query:
{
 "and" : [
 "BasisOfRecord is Specimen",
 "Continent is South America",
 "TaxonKey is Eriopidion Harley"
 ]
}

 The dataset includes 155 records from 40 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0009215-250426092105405/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.17632/xbz9vsr2sc
title: Geological risk prediction data for petroleum exploration

description: This sample set contains data from 235 exploration wells, each well contains six types of attribute information and exploration results, namely structure (ST), favorite structural index (FST), reservoir thickness (RTH), proportion of sandstone content (PS), hydrocarbon generation intensity (HG), cap rock thickness (CRT) and class label. c = 1 stands for productive well, and c = 0 stands for non-productive well. Supervised learning can be performed using the 6 attribute information and class labels, thereby forming an oil and gas risk prediction model
DOI: 10.6084/m9.figshare.9729314.v1
title: Gene expression profiling of SKOV-3 cells with or without PDK1 knocked down (Control versus siPDK1)

description: Created on 24 Aug 2019 - 01:28 by Michelle SiuTo examine the downstream targets of PDK1 in ovarian cancer. siRNA specifically targeting PDK1 (sc-36203) and control siRNA (Santa Cruz Biotechnology) were introduced into SKOV-3 cells using SilentFect for 48 hr. RNA was harvested using Trizol reagent. RNA preparation, library construction and sequencing with the BGISEQ-500 platform were performed at Beijing Genomics Institute (BGI, Shenzhen, China). 1) There are two methods to treat total RNA. Oligo (dT) magnetic beads are used to select mRNA with polyA tail, or hybridize the rRNA with DNA probe and digest the DNA/RNA hybrid strand, followed by DNase I reaction to remove DNA probe. Then obtain the target RNA after purification. 2) Fragment the target RNA and reverse transcription to double- strand cDNA (dscDNA) by N6 random primer. 3) End repair the dscDNA with phosphate at 5' end and stickiness 'A' at 3' end, then ligate and adaptor with stickiness 'T' at 3' end to the dscDNA. 4) Two specific primers are used to amplify the ligation product. 5) Denature the PCR product by heat and the single strand DNA is cyclized by splint oligo and DNA ligase. 6) Perform sequencing on prepared library. Gene expression levels were quantified using RNA-Seq by Expectation Maximization (RSEM) (Li and Dewey, 2011). The DEseq2 method was applied to detect differentially expressed genes (DEG) between groups. genome build: hg19Sample 1 (SK_C1_1): Control 1, SKOV-3<br>Sample 2 (SK_C2_1): Control 2, SKOV-3<br>Sample 3 (SK_siPD1_1): siPDK1 1, SKOV-3<br>Sample 4 (SK_siPD2_1): siPDK1 2, SKOV-3<br>SK_C-VS-SK_siPD.DEseq2_Method_GEO<br>
DOI: 10.17632/tgj8fpnp4t
title: One Dimensional Finite Element Analysis C# Program

description: One Dimensional Finite Element Analysis C# Program
DOI: 10.6084/m9.figshare.5242036.v1
title: Erratum: Docosahexaenoic Acid

description: Docosahexaenoic acid (DHA) is a long-chain, highly unsaturated omega-3 (n-3) fatty acid. It has a structure that gives it unique physical and functional properties. DHA is metabolically related to other n-3 fatty acids: it can be synthesised from the plant essential fatty acid α-linolenic acid (ALA). However, this pathway does not appear to be very efficient in many individuals, although the conversion of ALA to DHA is much better in young women than in young men. Furthermore, young infants may be more efficient converters of ALA to DHA than many adults, although the conversion rate is variable among infants. Many factors have been identified that affect the rate of conversion. The implication of poor conversion is that preformed DHA needs to be consumed. DHA is found in fairly high amounts in seafood, especially fatty fish, and in various forms of n-3 supplements. The amount of DHA in seafood and in supplements varies. Breast milk contains DHA. DHA is found esterified into complex lipids within the bloodstream, in adipose stores and in cell membranes. Its concentration in different compartments varies greatly. The brain and eye have high DHA contents compared to other organs. DHA is especially concentrated in the grey matter of the brain and in the rod outer segments of the retina. In the brain DHA is involved in neuronal signalling, while in the eye it is involved in the quality of vision. DHA is accumulated in the brain and eye late in pregnancy and in early infancy. A lower DHA content is linked to poorer cognitive development and visual function. DHA affects cell and tissue physiology and function through numerous mechanisms, including alterations in membrane structure and function, in membrane protein function, in cellular signalling and in lipid mediator production.
DOI: 10.17632/v7ckyyxv5j
title: IN2SIGHT_DES_POLIMI_WP2_PhysicalData_20220425

description: This dataset contains a set of data related to the characterization of the 2-photon polymerized microstructures for the IN2SIGHT project. Mostly, they are supplementary data for publications.