cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.5281/zenodo.14881227
title: Sequential changes in serum adipokines and their clinical impacts in critically ill covid-19 patients: a prospective study

description: This dataset contains data from the study titled "Sequential changes in serum adipokines and their clinical impacts in critically ill COVID-19 patients: a prospective study".

The study includes 30 critically ill COVID-19 patients admitted to the intensive care unit (ICU) and 10 healthy controls.Variables: The dataset contains demographic data, body mass index (BMI), APACHE-II scores, mechanical ventilation duration, nutritional parameters, and serum adipokine levels (adiponectin, GLP-1, resistin, visfatin, acyl ghrelin, IGF-1, leptin).Data Collection Process: Data was collected on admission (Day 0) and Day 7 of ICU stay.Purpose: This dataset can be used to investigate the metabolic and inflammatory changes in critically ill COVID-19 patients and explore the role of adipokines in critical illness.License: CC-BY 4.0 – The dataset can be freely used with proper attribution.
DOI: 10.5281/zenodo.14871840
title: Sequential changes in serum adipokines and their clinical impacts in critically ill covid-19 patients: a prospective study

description: This dataset contains data from the study titled "Sequential changes in serum adipokines and their clinical impacts in critically ill COVID-19 patients: a prospective study".

The study includes 30 critically ill COVID-19 patients admitted to the intensive care unit (ICU) and 10 healthy controls.Variables: The dataset contains demographic data, body mass index (BMI), APACHE-II scores, mechanical ventilation duration, nutritional parameters, and serum adipokine levels (adiponectin, GLP-1, resistin, visfatin, acyl ghrelin, IGF-1, leptin).Data Collection Process: Data was collected on admission (Day 0) and Day 7 of ICU stay.Purpose: This dataset can be used to investigate the metabolic and inflammatory changes in critically ill COVID-19 patients and explore the role of adipokines in critical illness.License: CC-BY 4.0 – The dataset can be freely used with proper attribution.
DOI: 10.5281/zenodo.14871841
title: Sequential changes in serum adipokines and their clinical impacts in critically ill covid-19 patients: a prospective study

description: This dataset contains data from the study titled "Sequential changes in serum adipokines and their clinical impacts in critically ill COVID-19 patients: a prospective study".

The study includes 30 critically ill COVID-19 patients admitted to the intensive care unit (ICU) and 10 healthy controls.Variables: The dataset contains demographic data, body mass index (BMI), APACHE-II scores, mechanical ventilation duration, nutritional parameters, and serum adipokine levels (adiponectin, GLP-1, resistin, visfatin, acyl ghrelin, IGF-1, leptin).Data Collection Process: Data was collected on admission (Day 0) and Day 7 of ICU stay.Purpose: This dataset can be used to investigate the metabolic and inflammatory changes in critically ill COVID-19 patients and explore the role of adipokines in critical illness.License: CC-BY 4.0 – The dataset can be freely used with proper attribution.
DOI: 10.5281/zenodo.14881264
title: Sequential changes in serum adipokines and their clinical impacts in critically ill covid-19 patients: a prospective study

description: This dataset contains data from the study titled "Sequential changes in serum adipokines and their clinical impacts in critically ill COVID-19 patients: a prospective study".

The study includes 30 critically ill COVID-19 patients admitted to the intensive care unit (ICU) and 10 healthy controls.Variables: The dataset contains demographic data, body mass index (BMI), APACHE-II scores, mechanical ventilation duration, nutritional parameters, and serum adipokine levels (adiponectin, GLP-1, resistin, visfatin, acyl ghrelin, IGF-1, leptin).Data Collection Process: Data was collected on admission (Day 0) and Day 7 of ICU stay.Purpose: This dataset can be used to investigate the metabolic and inflammatory changes in critically ill COVID-19 patients and explore the role of adipokines in critical illness.License: CC-BY 4.0 – The dataset can be freely used with proper attribution.
DOI: 10.15151/esrf-es-1976131184
title: IBS BAG

description: The IBS BAG includes in this proposal IBS teams and external groups from CEA-Cadarache (St Paul lez Durance) and IRBA (Brétigny-sur-Orge). We study structure-function relationships of proteins emphasizing in human health, biotechnology and methodology. Most of the projects are a continuation of the MX-2498 proposal and can be grouped into different topics as follows: host-pathogen interaction, new therapy targets, fundamental cellular mechanisms, membrane proteins, biotechnological applications and methodology. Some of these projects use integrative approaches (X-ray crystallography, cryo-EM, SAXS and NMR), together with other biophysical and biochemical studies, and very recently the use of AI, with the aim to fully understand the complexity of the biological macromolecular systems under study.
DOI: 10.15151/esrf-es-2008150048
title: 3D characterization of deformation mechanisms of the Achilles tendon enthesis using Texture tomography and phase contrast µCT

description: The enthesis is an insertion site of tendon into bone with a highly complex organization. Gradients in collagen and mineral content, organization and structure across the enthesis at multiple hierarchical levels provide it with exceptional mechanical properties. However, the local deformation mechanisms, especially at the nano- and microscale, are still poorly understood. This is partly due to the difficulties of studying the smaller length scales of this region in 3D. To this end, we propose to use Texture tomography (TexTOM), together µm phase contrast CT to study the mouse Achilles tendon enthesis during in situ mechanical testing to understand both the nano- and microscale deformation and load transfer mechanisms of the enthesis and their relation to the overall response of this interface.
DOI: 10.15151/esrf-es-2008025296
title: In situ biomineralization in sea urchin skeletogenic cell cultures

description: Biomimetic minerals are not on par with their natural counterpart, mostly due to lack of understanding regarding the biological control that is exerted during the mineral morphogenesis. Not only the physico-chemical attachment of monomers/precursors and their assembly is important, but also the biological control over the system. In addition to specific biomolecules, mechanosensing and subsequent mechanotransduction via the cytoskeleton is thought to shape the forming biomineral. We propose using sea urchin skeletogenic cell cultures to identify the influence of the cytoskeleton on biomineralization in situ, measuring different preparations of skeletogenic cells by means of XRD/XRF mapping to obtain spatially resolved information of processes taking part in shaping the nascent mineral phase and its crystallization. These experiments will allow to answer questions at the interface of the physico-chemical understanding of biomineralization and the biological control over this process.
DOI: 10.15151/esrf-es-2049021021
title: Microelectronic Components Charge Density vs. Temperature in Real Time

description: The objective of this proposal is to investigate the temperature dependence of charge density in microelectronic components under the action of pulsed X-ray as an alternative source that induces SEE. The main focus is on understanding how temperature affects charge density, since thermal generation of charge carriers increases with increasing temperature, which leads to an increase in the number of free carriers (electrons and holes) due to excitation from the valence band to the conduction band. Therefore, the number of SEE should increase with increasing temperature and lead to failure of the component.
DOI: 10.6084/m9.figshare.26332665
title: “Climate-Solutions Polarization”: A Value-based Approach to Understanding Polarization Dynamics around Biomass in Dutch Media Discourse

description: Polarization dynamics around climate change are shifting from debates about the reality and severity of climate change to debates about climate solutions. We propose taking a value-based approach to understanding “climate-solutions polarization”. As a case study, we identified the discursive value expressions underlying the polarized biomass media discourse in the Netherlands, from 2019–2021. A discourse analysis showed how the value expressions (a) climate security, (b) environmental benevolence, and (c) local security produce an opposition discourse, whereas the value expressions (d) climate achievement, (e) technological security, and (f) economic security underpin advocacy discourse. We discuss how the strong presence of security values provides both communication opportunities and risks for transitioning to climate-resilient societies. Further, our research shows how both sides of the debate have scientific actors on their side using distinctive rhetorical strategies, providing insight into debates about the role of values in science. The value-based approach to understanding climate-solutions polarization is promising for both the science and practice of environmental communication.
DOI: 10.6084/m9.figshare.26198936
title: A Risky Business? Climate Change and Meat Reduction in Aotearoa New Zealand. A Media Framing Analysis

description: The reduction of red meat in high-income countries is an impactful climate action and necessary to balance the projected growth of meat consumption in middle-income countries. Aotearoa New Zealand (herein Aotearoa) is a high-income country with elevated per capita greenhouse gas emissions. This research presents a media framing analysis of 58 news media stories on meat reduction as a climate action. It illuminates how arguments are constructed rhetorically and debates about meat reduction made convincing. Within Aotearoa media, a “risk” frame has been adopted for both pro meat reduction and anti-meat reduction positions. Arguments favoring reduction considered the risks of meat consumption to both human health and ecological systems. Arguments against meat reduction focused on risks to humans, relying on nutritional science to support claims. Both positions emphasized individual action and responsibility, presenting dietary “choice” as the foremost way to manage risk. In doing so, structural changes such as government policy change or food regulation were de-emphasized.
DOI: 10.6084/m9.figshare.26198936.v1
title: A Risky Business? Climate Change and Meat Reduction in Aotearoa New Zealand. A Media Framing Analysis

description: The reduction of red meat in high-income countries is an impactful climate action and necessary to balance the projected growth of meat consumption in middle-income countries. Aotearoa New Zealand (herein Aotearoa) is a high-income country with elevated per capita greenhouse gas emissions. This research presents a media framing analysis of 58 news media stories on meat reduction as a climate action. It illuminates how arguments are constructed rhetorically and debates about meat reduction made convincing. Within Aotearoa media, a “risk” frame has been adopted for both pro meat reduction and anti-meat reduction positions. Arguments favoring reduction considered the risks of meat consumption to both human health and ecological systems. Arguments against meat reduction focused on risks to humans, relying on nutritional science to support claims. Both positions emphasized individual action and responsibility, presenting dietary “choice” as the foremost way to manage risk. In doing so, structural changes such as government policy change or food regulation were de-emphasized.
DOI: 10.6084/m9.figshare.26332665.v1
title: “Climate-Solutions Polarization”: A Value-based Approach to Understanding Polarization Dynamics around Biomass in Dutch Media Discourse

description: Polarization dynamics around climate change are shifting from debates about the reality and severity of climate change to debates about climate solutions. We propose taking a value-based approach to understanding “climate-solutions polarization”. As a case study, we identified the discursive value expressions underlying the polarized biomass media discourse in the Netherlands, from 2019–2021. A discourse analysis showed how the value expressions (a) climate security, (b) environmental benevolence, and (c) local security produce an opposition discourse, whereas the value expressions (d) climate achievement, (e) technological security, and (f) economic security underpin advocacy discourse. We discuss how the strong presence of security values provides both communication opportunities and risks for transitioning to climate-resilient societies. Further, our research shows how both sides of the debate have scientific actors on their side using distinctive rhetorical strategies, providing insight into debates about the role of values in science. The value-based approach to understanding climate-solutions polarization is promising for both the science and practice of environmental communication.
DOI: 10.15468/dl.4fda4j
title: Occurrence Download

description: A dataset containing 186351 species occurrences available in GBIF matching the query:
{
 "and" : [
 "BasisOfRecord is one of (Observation, Human Observation, Specimen, Occurrence evidence)",
 "Month is one of (January, February, March, April, May, June, July, August, September, October, November, December)",
 "OccurrenceStatus is Present",
 "TaxonKey is Brassica L.",
 "Year 1990-2025"
 ]
}

 The dataset includes 186351 records from 1455 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0002599-250214102907787/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15151/esrf-es-1998133293
title: Investigating the interaction between SiC nanowhiskers and alpha-Mg dendrites during solidification via time resolved in situ X-Ray tomograp

description: SiC has long been the most widely recognised reinforcement for magnesium matrix composites (MgMC), yet the grain refinement mechanisms of SiC nanowhiskers (SiCnw) are still not fully understood. No direct observations of nanoparticles interacting with Mg dendrites have yet been documented. This study intends to conduct in-situ solidification experiments on MgMC using X-ray tomography at the ID19 beamline, observing the effects of SiCnw (diameter 650 nm, length 5 μm) on the nucleation and dendritic growth evolution of alpha-Mg grains. Subsequently, solidified samples will be scanned using diffraction contrast tomography (DCT) at the ID11 beamline to study the crystallographic orientation relationships between SiCnw, T2-Al2MgC2 phase and alpha-Mg. The experimental data will also be integrated with numerical simulations of grain growth, offering substantial insights into the study of the grain refining mechanism of SiCnw on Mg.
DOI: 10.15151/esrf-es-2007905037
title: Morphological and elemental characterization of human Glioblastoma Multiforme by multiscale and multimodal synchrotron analysis

description: We want to evaluate morphologic and elemental parameters of the human Glioblastoma Multiforme (GBM) brain tumor by using multi-scale and multi-modal synchrotron techniques, i.e. X-ray phase contrast tomography (X-PCI-CT) and X-ray fluorescence (XRF). GBM biopsies are studied to identify different tumor subtypes to be correlated with treatment outcome and illness progression. We intend: 1.to characterize the GBM microenvironment by micro & nano X-PCI-CT and quantify 3D microvasculature and cell stratification; 2.to characterize GBM elementally by XRF and create element maps within cells and vessels of GBM microenvironment; 3.to correlate synchrotron-derived information with parameters from non-invasive imaging, histopathology and molecular genetics; 4.to study the predictive value of the found parameters on disease classification and progression.
Success in this study will have a tremendous impact on GBM diagnosis and therapy. This study is the extension of the pilot experiment MD1376.
DOI: 10.15151/esrf-es-2007905323
title: The origin of jaws revealed by exceptional articulated fossils

description: The origin of jaws and teeth more than 420 million years ago is considered a key evolutionary innovation underpinning the diversity of modern vertebrates (animals with backbones). However, we lack a clear understanding of the origins of jaws and jawed vertebrates due to the extreme rarity of well-preserved and articulated fossils of the group’s oldest representatives. In this project, we will use synchrotron x-ray microtomography to reveal the anatomy of a series of unusually complete early jawed vertebrate fossils that preserve key anatomy for resolving this puzzle. We will use these results to generate three-dimensional virtual anatomical reconstructions, helping to fill a major gap in the origin of this important group. These data will allow us to test hypotheses about the origins of jaws and teeth, as well as testing theories about the wider evolution of the oldest jawed vertebrates.
DOI: 10.15151/esrf-es-2007905452
title: Distribution of different uranium oxidation states in thin sections of uranium-incubated bacterial cells

description: The microbial transformation of U(VI) to relatively insoluble U(IV) is a subject of extensive investigation but lacks a comprehensive understanding. This proposal aims to characterize the spatial distribution of different oxidation states of uranium following bioreduction by Desulfosporosinus hippei DSM 8344T, an anaerobic sulfate-reducing microorganism, and Desulfitobacterium sp. G1-2, an iron-reducing bacterium isolated from a bentonite sample. Thin-sectioned samples of uranium-incubated cells will be utilized for the first time for these investigations using High-Energy Resolution Fluorescence Detection (HERFD) at U M4 edge. Obtaining information about the various oxidation states and their distribution within or outside of the cells is crucial for gaining a more detailed understanding of the reduction process. This is of particular importance for the understanding of the bioreduction of U.
DOI: 10.15151/esrf-es-2007906912
title: High-pressure Synthesis of Aluminium Nitrides and Antimony Nirrides

description: Creating new high-energy density materials containing polymeric nitrogen is of great interest. Improved theoretical methods help predict crystal structures under extreme conditions of pressure and temperature. This approach has predicted several new Al-N phases with possible high-energy density properties. However, these phases still need to be experimentally verified. We have observed a new Al-N phase in our preliminary experiments with high-pressure laser heating (LH) experiments. This discovery motivates us to propose further investigations into this and other theoretically predicted phases. In this proposal, we propose to carry out the synthesis of metal nitrides and study their structural stability up to 50 GPa using synchrotron x-ray diffraction facilities.
DOI: 10.15151/esrf-es-2007782337
title: X-ray absorption spectroscopy for tracking the biomineralization of iron-based nanoparticles within cells

description: This proposal aims to investigate changes in iron oxide-based nanoheterostructures within the cellular environment for potential biomedical applications. Efficacy and toxicity are influenced by their transformation and degradation processes in the body. These nanoheterostructures can undergo remagnetization and recrystallization due to the biosynthesis of degraded elements in cells. Recent findings have shown that non-magnetic iron-based salts induce the formation of intracellular bioinorganic magnetic nanoparticles, with X-ray absorption spectroscopy (XAS) playing a crucial role in unraveling their progressive synthesis in mammalian cells. We propose a comprehensive study covering various maturation time points, using XAS at the Fe K-edge and Au L3-edge to examine iron-based nanoparticles combined with elements like Au in the cellular environment during different tissue maturation stages.
DOI: 10.15151/esrf-es-2007783903
title: Impact of implant-associated particle exposure in human lymph nodes on the immune-cell profiles

description: Modern medicine relies heavily on metal implants. Recent studies suggest that even low levels of metal exposure can activate T-cell-mediated hypersensitivity reactions, leading to chronic inflammation and implant failure. However, the causal link between 'metal allergy' and the condition of the implant is still unknown. Our initial feasibility analysis revealed the presence of implant-associated particles in the lymph nodes of one patient, providing a basis for further systematic investigation. It is essential to reveal how implant –associated metals are presented to T cells in the lymph nodes. We aim to quantify and spatially correlate metal exposure, protein and immune cell distribution in human lymph node sections by combining µXRF and µXANES analysis with mass spectrometry-based molecular imaging techniques. We will provide new insights into the biological effects of implant-related metal exposure and their role in the chronic inflammation associated with implant failure.
DOI: 10.15151/esrf-es-2007785525
title: In-situ EXAFS measurements of multi-principal metal alloy under pressure

description: We propose to perform in-situ EXAFS in CrCoNi alloy during compression in a diamond anvil cell (DAC) to reveal local chemical ordering. We hypothesize that, under GPa pressures, the massively induced dislocations and slip bands will cause a directional version of chemical redistribution. Specifically, rapid Ni diffusion could enable its segregation and ordering along the shear band, in which the deformation strain is highly concentrated. As EXAFS measures the pair distribution function (PDF) with elemental specificity, we will measure if the applied pressure creates anisotropy in the PDF reminiscent of solute segregation along slip bands. By integrating the measured PDFs with our molecular dynamics simulations under analogous conditions, we will explore how different types of slip systems could cause the pressure-dependent segregation. Our study will enhance current knowledge of how solute segregation and local chemical order govern the mechanism of pressure-induced plasticity.
DOI: 10.15151/esrf-es-2007785680
title: Density of carbonatite melts under pressure and the mobility of carbon in the upper mantle

description: Here we aim at measuring the density of hydrous carbonatite melts (&gt; 40 wt% CO2, &lt; 15 wt% SiO2, &lt; 10 wt% H2O) that are representative of carbon-rich melts
 produced by the partial melting of carbonated mantle rocks between 50 and 200 km depth. These melts play a key role in the geochemical and geodynamical
 evolution of the mantle, in the transport of carbon to the surface and in the regulation of the deep carbon cycle. Density will be measured between 1-5 GPa and
 1300-2000 K in a panoramic Paris-Edinburgh (PE) press by the X-ray absorption technique at ID27 beamline. The results will provide insights into the mobility of
 carbonated melts at depth and their role as carbon reservoirs and carriers in the Earth’s interior.
DOI: 10.15151/esrf-es-2007786151
title: In-situ microstructural evolution study of additively manufactured Zr-based bulk metallic glasses using advanced laser beam shaping technolo

description: It is planned to perform in-situ during x-ray diffraction during laser powder bed fusion (LPBF) of metallic glasses (Zr-based) using a mini LPBF device with new laser optical system that allows to better control the energy input in order to achieve highly optimized conditions to better control the reheating of the material. As metallic glasses are very sensitive to the reheating conditions they are a perfect probe material to test this new technology and new understanding regarding the structure formation are expected.