cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.5281/zenodo.10039539
title: A Systematic Review on Potential Phytoconstituents with Antiulcer Activity

description: A frequent gastrointestinal illness that affects many people is ulcer. Basically, it is a swollen tear in the skin or the mucous membrane lining the digestive tract. When the natural equilibrium is upset by increased aggression or decreased mucosal resistance, ulceration results. It might be brought on by consistent drug use, strange eating patterns, stress, and other factors. Peptic ulcers are a general name for digestive system ulcers in the stomach or duodenum. The presence of acid and peptic activity in gastric juice, as well as a breakdown in mucosal defences, all contributes to the development of peptic ulcers. There are several synthetic medications available to treat ulcers. But compared to herbal remedies, these medications are more expensive and likely to have greater negative effects. According to the literature, many Ayurveda doctors and traditional healers utilize a variety of medicinal herbs and polyherbal combinations to cure ulcers. Pain relief, ulcer healing, and postponing ulcer recurrence are the ideal goals of treatment for peptic ulcer disease. An attempt has been made in this review to learn about various medicinal plants that could be used in both Ayurvedic and modern science for the treatment or prevention of peptic ulcer.
DOI: 10.6084/m9.figshare.9968888
title: Kinetic study on the effect of di-tert-butyl peroxide and 2-ethylhexyl nitrate on the reactivity of toluene primary reference fuels

description: Fuel additives have shown to provide an important contribution to control the auto-ignition process of the homogeneous charge compression ignition (HCCI) and reactivity-controlled compression ignition (RCCI). In this work a kinetic modeling study has been conducted to study the effects of di-tert-butyl peroxide (DTBP) and 2-ethylhexyl nitrate (EHN) on the reactivity of toluene primary reference fuels (TPRF). The kinetic analysis at engine-like conditions showed that for TPRF, the first-stage heat release was similar for the two additives. However, in the case of EHN the OH precursor nitrous acid (common isomer HONO) was formed in significant amounts during the induction period which eventually lead to a faster high-temperature ignition. This was in contrast to primary reference fuels where the ignition enhancing effect of DTBP was more significant compared to EHN as a result of a more pronounced first-stage heat release when adding DTBP and a lesser amount of nitrous acid formed when adding EHN compared to a TPRF. Using a TPRF as gasoline surrogate fuel could reproduce the trends in RON as function of added EHN and DTBP for a commercial gasoline, indicating the importance to include fuel sensitivity (RON-MON) in a surrogate fuel.
DOI: 10.6084/m9.figshare.9968888.v1
title: Kinetic study on the effect of di-tert-butyl peroxide and 2-ethylhexyl nitrate on the reactivity of toluene primary reference fuels

description: Fuel additives have shown to provide an important contribution to control the auto-ignition process of the homogeneous charge compression ignition (HCCI) and reactivity-controlled compression ignition (RCCI). In this work a kinetic modeling study has been conducted to study the effects of di-tert-butyl peroxide (DTBP) and 2-ethylhexyl nitrate (EHN) on the reactivity of toluene primary reference fuels (TPRF). The kinetic analysis at engine-like conditions showed that for TPRF, the first-stage heat release was similar for the two additives. However, in the case of EHN the OH precursor nitrous acid (common isomer HONO) was formed in significant amounts during the induction period which eventually lead to a faster high-temperature ignition. This was in contrast to primary reference fuels where the ignition enhancing effect of DTBP was more significant compared to EHN as a result of a more pronounced first-stage heat release when adding DTBP and a lesser amount of nitrous acid formed when adding EHN compared to a TPRF. Using a TPRF as gasoline surrogate fuel could reproduce the trends in RON as function of added EHN and DTBP for a commercial gasoline, indicating the importance to include fuel sensitivity (RON-MON) in a surrogate fuel.
DOI: 10.5281/zenodo.10039573
title: Development and Validation of UV-Spectrophotometric and Stability Indicating RP-HPLC Method of Calcipotriene in Bulk Drug and Pharmaceutical Formulation

description: The objective of current study was to develop and validate stability indicating UV Spectrophotometric and RP-HPLC method for Calcipotriene in bulk drug and pharmaceutical formulation. UV Spectrophotometric method was developed utilizing Analytical Technologies limited. Detection was carried out at absorption maxima at 260nm using methanol as a solvent. Beer's law was followed in the concentration range of 5-25 µg/mL, and the drug was quantitated using A1% 1cm at 260 nm, which produced a correlation coefficient that was less than 1. The Chromatographic separation of analyte was achieved on Agilent C18 (4.6mm x 250mm, 5µm) column with mobile phase consisting of Methanol and 0.1 % Acetic Acid in the ratio of 65:35% v/v at flow rate of 1.0 ml/min. The retention time was found to be 5.273 min. Calcipotriene was subjected to forced degradation studies under different stress conditions like acid hydrolysis, alkaline hydrolysis, and hydrogen peroxide oxidation. The developed method was validated according to the guidelines of International Conference on Harmonization (ICH) for various parameters like linearity, precision, accuracy, robustness, limit of detection and limit of quantitation. The findings showed that the method performed well in accordance with the standards. The proposed method is simple, accurate, precise, economic, reproducible and stability indicating and hence suitable for routine quality control analysis of Calcipotriene in bulk drug as well as in formulations.
DOI: 10.5281/zenodo.10039572
title: Development and Validation of UV-Spectrophotometric and Stability Indicating RP-HPLC Method of Calcipotriene in Bulk Drug and Pharmaceutical Formulation

description: The objective of current study was to develop and validate stability indicating UV Spectrophotometric and RP-HPLC method for Calcipotriene in bulk drug and pharmaceutical formulation. UV Spectrophotometric method was developed utilizing Analytical Technologies limited. Detection was carried out at absorption maxima at 260nm using methanol as a solvent. Beer's law was followed in the concentration range of 5-25 µg/mL, and the drug was quantitated using A1% 1cm at 260 nm, which produced a correlation coefficient that was less than 1. The Chromatographic separation of analyte was achieved on Agilent C18 (4.6mm x 250mm, 5µm) column with mobile phase consisting of Methanol and 0.1 % Acetic Acid in the ratio of 65:35% v/v at flow rate of 1.0 ml/min. The retention time was found to be 5.273 min. Calcipotriene was subjected to forced degradation studies under different stress conditions like acid hydrolysis, alkaline hydrolysis, and hydrogen peroxide oxidation. The developed method was validated according to the guidelines of International Conference on Harmonization (ICH) for various parameters like linearity, precision, accuracy, robustness, limit of detection and limit of quantitation. The findings showed that the method performed well in accordance with the standards. The proposed method is simple, accurate, precise, economic, reproducible and stability indicating and hence suitable for routine quality control analysis of Calcipotriene in bulk drug as well as in formulations.
DOI: 10.18716/dch/a.00000028
title: Russian Sign Language conversations

description: This corpus is a collection of video recordings of natural face-to-face conversations in Russian Sign Language by Deaf native Russian signers who live in Germany. At the moment 3 dialogue conversations of 40-60 minutes each were recorded at the University of Cologne from 2021-2023, in total ca. 3 hours of data. Most of the signers were well acquainted. Only two participants did not know each other. The participants were allowed to talk about any topic they wanted. The conversations cover a rage of topics (e.g. their life in Russian before they immigrated to Germany, the Deaf lives in Europe and Russian etc.). The language material was captured in optimal conditions using frontal view HD camera with green background. At the moment the corpus contains data from 5 participants (mean age 53 years old). The video recordings will be accompanied with ELAN transcriptions and annotations with a focus on discourse organization and conversational interaction and with particular attention to non-manual signals (such as head nods, head shake, eye gaze, eye blinks, mouth gesture, nose wrinkles, face expressions, eyebrow and lip movement). The data has been elicited for the purposes of conducting the project "Eine korpusbasierte Untersuchung der Mundbilder und des Fingeralphabets in der Russischen Gebärdensprache: Beschreibung und Implikationen für den intermodalen Sprachkontakt" funded by DGF (2017-2022). As the project is aimed at describing two cross-modal sign language phenomena (mouthing and fingerspelling), a special focus has given to the annotations of mouth movements and fingeralphabet.
DOI: 10.6084/m9.figshare.24433327
title: Supplementary Material for: The applicability of scoring calyculin A-induced premature chromosome condensation (PCC) objects for dose assessment including for radiotherapy patients

description: As an extension to a previous study, a linear calibration curve covering doses from 0 to 10 Gy was constructed and evaluated in the present study using calyculin A-induced premature chromosome condensation (PCC) by scoring excess PCC objects. The main aim of this study was to assess the applicability of this PCC assay for doses below 2 Gy that are critical for triage categorisation. Two separate blind tests involving a total of 6 doses were carried out. 4 out of 6 dose estimates were within the 95% confidence limits (95%CL) with the other 2 just outside. In addition, blood samples from five cancer patients undergoing external beam radiotherapy (RT) were also analysed and the results showed whole-body dose estimates statistically comparable to the dicentric chromosome assay (DCA) results. This is the first time that calyculin A-induced PCC was used to analyse clinical samples by scoring excess objects. Although dose estimates for the pre-RT patient samples were found to be significantly higher than the mean value for the healthy donors and were also significantly higher than those obtained using DCA, all these pre-treatment patients fell into the same category as those who may have received a low dose (&lt; 1 Gy) and do not require immediate medical care during emergency triage. Additionally, for radiological accidents with unknown exposure scenario, PCC objects and rings can be scored in parallel for the assessment of both low and high dose exposures. In conclusion, scoring excess objects using calyculin A-induced PCC is confirmed to be another potential biodosimetry tool in radiological emergency particularly in mass casualty scenarios even though the data need to be interpreted with caution when cancer patients are among the casualties.
DOI: 10.6084/m9.figshare.24433327.v1
title: Supplementary Material for: The applicability of scoring calyculin A-induced premature chromosome condensation (PCC) objects for dose assessment including for radiotherapy patients

description: As an extension to a previous study, a linear calibration curve covering doses from 0 to 10 Gy was constructed and evaluated in the present study using calyculin A-induced premature chromosome condensation (PCC) by scoring excess PCC objects. The main aim of this study was to assess the applicability of this PCC assay for doses below 2 Gy that are critical for triage categorisation. Two separate blind tests involving a total of 6 doses were carried out. 4 out of 6 dose estimates were within the 95% confidence limits (95%CL) with the other 2 just outside. In addition, blood samples from five cancer patients undergoing external beam radiotherapy (RT) were also analysed and the results showed whole-body dose estimates statistically comparable to the dicentric chromosome assay (DCA) results. This is the first time that calyculin A-induced PCC was used to analyse clinical samples by scoring excess objects. Although dose estimates for the pre-RT patient samples were found to be significantly higher than the mean value for the healthy donors and were also significantly higher than those obtained using DCA, all these pre-treatment patients fell into the same category as those who may have received a low dose (&lt; 1 Gy) and do not require immediate medical care during emergency triage. Additionally, for radiological accidents with unknown exposure scenario, PCC objects and rings can be scored in parallel for the assessment of both low and high dose exposures. In conclusion, scoring excess objects using calyculin A-induced PCC is confirmed to be another potential biodosimetry tool in radiological emergency particularly in mass casualty scenarios even though the data need to be interpreted with caution when cancer patients are among the casualties.
DOI: 10.25747/2rdd-rc08
title: Data of real-time prediction of Wikipedia articles' quality
DOI: 10.5281/zenodo.10039590
title: Overview of Stress: Insights from the Stress System, Posttraumatic Stress Disorder and Recent Approaches

description: Stress is an excessive, improper, or exaggerated response to a circumstance. Stress is a common occurrence in a rapidly expanding global population, with most people experiencing stress as a result of daily issues such as financial problems, family problems, educational problems, and so on. Despite the fact that the entire CNS has a direct or indirect function in maintaining general body homeostasis, several regions of the brain play crucial, unique roles in coordinating the stress response. The stress system plays a major role here via two different pathways, i.e., the HPA axis pathway and the sympatho-adreno-medulary (SAM) axis pathway. These two pathways work in response to stress by releasing different neurotransmitters in the brain and managing stress with positive and negative feedback mechanisms. This long-term exposure to chronic stress increases the chances of developing stress-related disorders like PTSD. Post-traumatic stress disorder (PTSD) is a disabling condition that often arises after exposure to a stressful event and affects around 8% of the population during their lifetime. To date, there is no effective treatment available for PSTD other than some antidepressants. Recently Ketamine has gained popularity in recent PSTD approaches as a good candidate for treating PTSD. In this review, we focus on the entire stress system, its treatments, and recent approaches.
DOI: 10.5281/zenodo.10039589
title: Overview of Stress: Insights from the Stress System, Posttraumatic Stress Disorder and Recent Approaches

description: Stress is an excessive, improper, or exaggerated response to a circumstance. Stress is a common occurrence in a rapidly expanding global population, with most people experiencing stress as a result of daily issues such as financial problems, family problems, educational problems, and so on. Despite the fact that the entire CNS has a direct or indirect function in maintaining general body homeostasis, several regions of the brain play crucial, unique roles in coordinating the stress response. The stress system plays a major role here via two different pathways, i.e., the HPA axis pathway and the sympatho-adreno-medulary (SAM) axis pathway. These two pathways work in response to stress by releasing different neurotransmitters in the brain and managing stress with positive and negative feedback mechanisms. This long-term exposure to chronic stress increases the chances of developing stress-related disorders like PTSD. Post-traumatic stress disorder (PTSD) is a disabling condition that often arises after exposure to a stressful event and affects around 8% of the population during their lifetime. To date, there is no effective treatment available for PSTD other than some antidepressants. Recently Ketamine has gained popularity in recent PSTD approaches as a good candidate for treating PTSD. In this review, we focus on the entire stress system, its treatments, and recent approaches.
DOI: 10.6084/m9.figshare.24298600
title: Supplementary Material for: Two cases of exacerbation of asthma during treatment with enfortumab vedotin

description: Enfortumab vedotin is an antibody-drug conjugate against nectin-4 that is recently being used in the management of patients with urothelial carcinoma. The common adverse events include rashes, peripheral neuropathy, and hyperglycemia. Only a few cases of associated respiratory symptoms have been reported. Herein, we describe two patients with advanced urothelial carcinoma who experienced asthma exacerbation after initiating enfortumab vedotin treatment. Both patients improved with inhalation therapy. Since nectin-4 is expressed in the tracheal epithelium, its association with asthma is likely. This study highlights that clinicians should caution patients with a history of asthma against the worsening of respiratory symptoms when enfortumab vedotin is administered.
DOI: 10.6084/m9.figshare.24433348
title: Synergistic effects of climate, soil and human activities on plant competition and facilitation across five global major biomes

description: The dataset of the GCB paper
DOI: 10.6084/m9.figshare.24433348.v1
title: Synergistic effects of climate, soil and human activities on plant competition and facilitation across five global major biomes

description: The dataset of the GCB paper
DOI: 10.6084/m9.figshare.24137403
title: Supplementary Material for: Continuous erythropoietin receptor activator for the treatment of chronic dialysis patients with renal anemia in daily clinical practice in Poland: A non-interventional, multi-center, pragmatic NAVIGO trial

description: Background: Renal anemia is one of the most common complications of chronic kidney disease. This real-life study assessed the effectiveness of methoxy polyethylene glycol-epoetin beta, a continuous erythropoietin receptor activator (C.E.R.A.), for the treatment of chronic kidney disease (CKD)-associated anemia in patients receiving dialysis in daily clinical practice. Methods: 247 patients receiving chronic intermitted dialysis in 26 centers in Poland with CKD-associated symptomatic anemia, ESA-naïve, and with balanced iron stores in the investigators’ opinion were enrolled this real-life study. Over 12 months, the following data were collected: Hb concentration and dosage, route of administration and dosing scheme of C.E.R.A., dialysis adequacy, adverse events, iron therapy, and blood transfusions. Results: During the treatment, a Hb concentration of ≥10 g/dL was noted in 90.9% of hemodialysis patients (n=224) and 96.0% of peritoneal dialysis patients (n=23). At baseline, 7.8% of patients had a Hb concentration of 10–12 g/dL, which increased to 63.3% after 12 months. The median time when Hb concentration was maintained within 10–12 g/dL was 115.2 [IQR 49.1–188.7] days. A Hb concentration ≥12 g/dL was observed after 7 months of treatment in a maximum of 24.1% of hemodialysis patients, and 31.8% of peritoneal dialysis patients. The median time elapsed between the start of treatment and the first Hb concentration &gt;10 g/dL was 42.0 [21.0–78.2] days. C.E.R.A. was well tolerated. Conclusions: C.E.R.A. corrects CKD-associated anemia in dialysis patients, and maintains Hb levels within the recommended target range. The study also confirmed the acceptable safety profile of the drug. Study identifier at ClinicalTrials.gov: NCT01690455
DOI: 10.6084/m9.figshare.24137403.v1
title: Supplementary Material for: Continuous erythropoietin receptor activator for the treatment of chronic dialysis patients with renal anemia in daily clinical practice in Poland: A non-interventional, multi-center, pragmatic NAVIGO trial

description: Background: Renal anemia is one of the most common complications of chronic kidney disease. This real-life study assessed the effectiveness of methoxy polyethylene glycol-epoetin beta, a continuous erythropoietin receptor activator (C.E.R.A.), for the treatment of chronic kidney disease (CKD)-associated anemia in patients receiving dialysis in daily clinical practice. Methods: 247 patients receiving chronic intermitted dialysis in 26 centers in Poland with CKD-associated symptomatic anemia, ESA-naïve, and with balanced iron stores in the investigators’ opinion were enrolled this real-life study. Over 12 months, the following data were collected: Hb concentration and dosage, route of administration and dosing scheme of C.E.R.A., dialysis adequacy, adverse events, iron therapy, and blood transfusions. Results: During the treatment, a Hb concentration of ≥10 g/dL was noted in 90.9% of hemodialysis patients (n=224) and 96.0% of peritoneal dialysis patients (n=23). At baseline, 7.8% of patients had a Hb concentration of 10–12 g/dL, which increased to 63.3% after 12 months. The median time when Hb concentration was maintained within 10–12 g/dL was 115.2 [IQR 49.1–188.7] days. A Hb concentration ≥12 g/dL was observed after 7 months of treatment in a maximum of 24.1% of hemodialysis patients, and 31.8% of peritoneal dialysis patients. The median time elapsed between the start of treatment and the first Hb concentration &gt;10 g/dL was 42.0 [21.0–78.2] days. C.E.R.A. was well tolerated. Conclusions: C.E.R.A. corrects CKD-associated anemia in dialysis patients, and maintains Hb levels within the recommended target range. The study also confirmed the acceptable safety profile of the drug. Study identifier at ClinicalTrials.gov: NCT01690455
DOI: 10.18167/dvn1/tebfmy
title: Modélisation et prédiction des surfaces en eau en périphérie des aires protégées du Zimbabwe

description: L'objectif de ce projet est de modéliser les surfaces en eau quotidiennes des points d'eau en milieu semi-aride à l'aide d'un modèle développé par Soti et al. Le modèle hydraulique a besoin en entrée des précipitations journalières (ici sous forme raster, issues de TAMSAT) et de la surface maximale de chaque point d'eau étudié. Cette étude s'est concentrée sur un site en bordure d'une aire protégée, entre les parcs nationaux de Dete et Hwange, au Zimbabwe. Les données pluviométriques utilisées sont datées du 15/09/2007 au 15/09/2017.
DOI: 10.18167/dvn1/fhwgze
title: Corpus annoté de transcriptions de vidéos Youtube concernant les actualités en Afrique de l’Ouest de janvier à mars 2022

description: Corpus annoté de 1109 transcriptions de vidéos Youtube concernant les actualités en Afrique de l’Ouest de janvier à mars 2022.
DOI: 10.5281/zenodo.10039607
title: Development and Validation of UV-Spectroscopy and UHPLC Method for Gemfibrozil in Bulk Drug and Pharmaceutical Dosage Form

description: The present study attempts to validate the approach by UV-Spectroscopy at a wavelength of 273nm. The UHPLC separation was performed using reversed phase chromatography on a C18 column (100mmX4.6mm, 2.5m) in gradient mode at a flow rate of 1.0 mL min. At a wavelength of 273nm, diode array detection was performed using a mobile phase composed of a 50:50 (v/v) mixture of methanol and water (0.1% acetic acid).The technique for Gemfibrozil was linear in the concentration range of 5 - 25 g/ml, with a correlation coefficient of 0.9991. For Gemfibrozil, the limit of detection was 0.1058 g/ml. The limit of quantification for Gemfibrozil was 0.3208 g/ml. The analyte recovers at a rate of 98%-102% on average. The approach was found to be accurate, precise, specific, linear calibration curve, and resilient for both pure and pharmaceutical dosage forms. The method was validated in terms of linearity, recovery, accuracy, specificity, LOD/LOQ values, and solution stability, and it was effectively employed for Gemfibrozil determination. For Gemfibrozil, a simple, precise, accurate, and fast ultra high-performance liquid chromatographic (UHPLC) method has been designed and validated.