cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.17894/ucph.8ab1103b-a93c-4d72-a9a0-c1bf11a231e8
title: Data_Temperature_induced_shifts_of_Yu-Shiba-Rusinov_resonances_in_nanowire-based_hybrid_quantum_dots

description: Experimental data from the manuscript "Temperature induced shifts of Yu-Shiba-Rusinov resonances in nanowire-based hybrid quantum dots". Authors: Juan Carlos Estrada Saldana, Alexandros Vekris, Victoria Sosnovtseva, Thomas Kanne, Peter Krogstrup, Kasper Grove-Rasmussen, and Jesper Nygård Year of Publication: 2020 arXiv:2002.12882
DOI: 10.25625/3dvvvn/0qoish
title: DeHa2010biljou_soil.txt

description: :unav
DOI: 10.25625/3dvvvn/ct1kps
title: GSSandGSE.R

description: :unav
DOI: 10.25625/3dvvvn/kbn0nd
title: DE-Hai_SoilModelResults_Opt_Text_TRUE_useDUL_FALSE_saturationLowerLevel_FALSE.RData

description: :unav
DOI: 10.25625/3dvvvn/lloqxj
title: DE-Tha_SoilModelResults_Opt_Text_FALSE_useDUL_FALSE_saturationLowerLevel_TRUE.RData

description: :unav
DOI: 10.25625/3dvvvn/lzzd9m
title: DE-Tha_SoilModelResults_Opt_Text_FALSE_useDUL_FALSE_saturationLowerLevel_TRUE.RData

description: :unav
DOI: 10.25625/3dvvvn/vsgg3f
title: US-Me2_SoilModelResults_Opt_Text_FALSE_useDUL_FALSE_saturationLowerLevel_TRUE.RData

description: :unav
DOI: 10.25625/3dvvvn/w0yhze
title: DeHa2014_biljou_met.txt

description: :unav
DOI: 10.5281/zenodo.3786444
title: Data for 'Robust Enhancement of Tropical Convective Activity by the 2019 Antarctic Sudden Stratospheric Warming'

description: These data were used for making plots in the manuscript entitled 'Robust Enhancement of Tropical Convective Activity by the 2019 Antarctic Sudden Stratospheric Warming'. Data format is NetCDF.
DOI: 10.25625/3dvvvn/1teqjz
title: US-Syv_SoilModelResults_Opt_Text_TRUE_useDUL_FALSE_saturationLowerLevel_FALSE.RData

description: :unav
DOI: 10.25625/3dvvvn/2e7ft6
title: US-Syv_SoilModelResults_Opt_Text_FALSE_useDUL_TRUE_saturationLowerLevel_TRUE.RData

description: :unav
DOI: 10.25625/3dvvvn/5i9etu
title: DroughtPublication.R

description: :unav
DOI: 10.25625/3dvvvn/9oginn
title: DeHa2005_biljou_met.txt

description: :unav
DOI: 10.25625/3dvvvn/amzgjh
title: ReadData.R

description: :unav
DOI: 10.25625/3dvvvn/dcisjv
title: effectofDepthCalibrated.RData

description: :unav
DOI: 10.25625/3dvvvn/htjyqd
title: IT-Lav_SoilModelResults_Opt_Text_FALSE_useDUL_TRUE_saturationLowerLevel_FALSE.RData

description: :unav
DOI: 10.25625/3dvvvn/v9tz8f
title: US-MMSSoilModelData.RData

description: :unav
DOI: 10.5284/1076946
title: The Charles Archive: A project to digitally preserve and make publicly accessible the practice archive of F W B and Mary Charles Chartered Architects

description: F.W.B. 'Freddie' Charles (1912-2002) was an architect and nationally recognised expert on the conservation and repair of timber-framed buildings. Freddie and his wife, architect Mary Charles (nee Logan) (1924-2005) set up in practice in 1962 and were amongst the first to face the challenges associated with timber-frame conservation. They were involved with the restoration of many important timber-framed buildings during their career including over 250 buildings in Worcestershire, many of them of national importance. The practice also worked in a number of other counties including Gloucestershire, Herefordshire, Nottinghamshire, Shropshire, Staffordshire, Warwickshire (including Coventry) and Birmingham. Freddie died in 2002 and prior to his death the practice archive was deposited with the then Worcestershire Record Office and a number of other archive services geographically relevant to the locations where the practice had worked. In 2017 Historic England agreed to fund a project to make the practice archive of F.W.B and Mary Charles more accessible. Project aims included electronically cataloguing the archive, which had previously only been catalogue' on paper, and creating a digital archive of important material, to be made publically available. The Charles Archive digital archive includes an extensive collection of high resolution photographs, slides, plans and drawings, relating to buildings across Worcestershire, held within the practice archive of F.W.B. 'Freddie' Charles (1912-2002) and Mary Charles (nee Logan) (1924-2005). The original archive is under the care of the Worcestershire Archive and Archaeology Service, a service of Worcestershire County Council. The Charles practice also worked in a number of other counties including Gloucestershire, Herefordshire, Nottinghamshire, Shropshire, Staffordshire, Warwickshire (including Coventry) and Birmingham and as such a number of other archive services, geographically relevant to the locations where the practice worked, care for original archive material. The Charles Archive digital archive includes material related to buildings across Worcestershire, including its historic towns and Worcester City. Many of these buildings are nationally protected and registered on Historic England's National Heritage List for England (NHLE). Examples include the Grade I listed Tithe Barn at Bredon (List Entry Number 1319631), the Grade I listed Cruck Barn at Leigh Court (List Entry Number 1349245) and the Grade I listed Tithe Barn at Middle Littleton (List Entry Number 1350092). Others, while not nationally protected, are recognised as locally significant buildings on the Worcestershire County Council Historic Environment Record and Worcester City Historic Environment Record.
DOI: 10.25625/3dvvvn/0y7sv6
title: DE-Hai_SoilModelResults_Opt_Text_FALSE_useDUL_FALSE_saturationLowerLevel_TRUE.RData

description: :unav
DOI: 10.25625/3dvvvn/bn7efo
title: ModelCalibrationMF.RData

description: :unav
DOI: 10.25625/3dvvvn/grwqwr
title: NL-Loo_SoilModelResults_Opt_Text_FALSE_useDUL_TRUE_saturationLowerLevel_TRUE.RData

description: :unav
DOI: 10.25625/3dvvvn/ms36to
title: NL-Loo_SoilModelResults_Opt_Text_TRUE_useDUL_TRUE_saturationLowerLevel_TRUE.RData

description: :unav
DOI: 10.25625/3dvvvn/olhwcy
title: DK-Sor_EffectOfDepth.png

description: :unav
DOI: 10.25625/3dvvvn/qx9mvb
title: DK-Sor_SoilModelResults_Opt_Text_FALSE_useDUL_FALSE_saturationLowerLevel_FALSE.RData

description: :unav
DOI: 10.25625/3dvvvn/vf7iui
title: BE-Vie_SoilModelResults_Opt_Text_TRUE_useDUL_TRUE_saturationLowerLevel_TRUE.RData

description: :unav
DOI: 10.25625/3dvvvn/wgmmhl
title: RU-Fyo.Metdata.png

description: :unav
DOI: 10.25625/3dvvvn/zw8eb5
title: US-MMS_SoilModelResults_Opt_Text_TRUE_useDUL_TRUE_saturationLowerLevel_FALSE.RData

description: :unav
DOI: 10.25625/3dvvvn/0uq5ft
title: US-Syv_SoilModelResults_Opt_Text_FALSE_useDUL_FALSE_saturationLowerLevel_FALSE.RData

description: :unav
DOI: 10.25625/3dvvvn/3caj0k
title: DataPreparation.R

description: :unav
DOI: 10.25625/3dvvvn/6qvyan
title: IT-Lav_SoilModelResults_Opt_Text_FALSE_useDUL_FALSE_saturationLowerLevel_TRUE.RData

description: :unav
DOI: 10.25625/3dvvvn/7dp0km
title: DE-Tha_SoilModelResults_Opt_Text_FALSE_useDUL_FALSE_saturationLowerLevel_FALSE.RData

description: :unav
DOI: 10.25625/3dvvvn/blw2ah
title: BE-Vie_SoilModelResults_Opt_Text_FALSE_useDUL_FALSE_saturationLowerLevel_FALSE.RData

description: :unav
DOI: 10.25625/3dvvvn/fy326s
title: US-MMS_SoilModelResults_Opt_Text_FALSE_useDUL_FALSE_saturationLowerLevel_TRUE.RData

description: :unav
DOI: 10.25625/3dvvvn/hcbzjb
title: DE-Hai_SoilModelResults_Opt_Text_TRUE_useDUL_TRUE_saturationLowerLevel_FALSE.RData

description: :unav
DOI: 10.25625/3dvvvn/jczap5
title: IT-RenSoilModelData.RData

description: :unav
DOI: 10.25625/3dvvvn/46ijvt
title: US-Syv_SoilModelResults_Opt_Text_TRUE_useDUL_FALSE_saturationLowerLevel_TRUE.RData

description: :unav
DOI: 10.25625/3dvvvn/bp3wbc
title: Fig_Improvement_in_SL_Rsquare_AllCases.jpeg

description: :unav
DOI: 10.25625/3dvvvn/pdxhd6
title: FiguresPaper.R

description: :unav
DOI: 10.25625/3dvvvn/qbd6s3
title: NL-Loo_EffectOfDepth.png

description: :unav
DOI: 10.25625/3dvvvn/rdtmbe
title: DE-LnfSoilModelData.RData

description: :unav
DOI: 10.25625/3dvvvn/uml1cl
title: BE-Bra_SoilModelResults_Opt_Text_TRUE_useDUL_TRUE_saturationLowerLevel_TRUE.RData

description: :unav
DOI: 10.5255/ukda-sn-854317
title: Improving the experience of dementia and enhancing active life: living well with dementia cohort study 2016-2018
DOI: 10.18112/openneuro.ds002727.v1.0.2
title: EMOTIVE IDIOMS
DOI: 10.25625/3dvvvn/029cdb
title: IT-Lav_SoilModelResults_Opt_Text_TRUE_useDUL_TRUE_saturationLowerLevel_FALSE.RData

description: :unav
DOI: 10.25625/3dvvvn/6fpemj
title: DK-Sor_SoilModelResults_Opt_Text_TRUE_useDUL_FALSE_saturationLowerLevel_TRUE.RData

description: :unav
DOI: 10.25625/3dvvvn/6lqd2o
title: MetDataPreparation_Hai-Lnf.R

description: :unav
DOI: 10.25625/3dvvvn/ab4tnf
title: DK-Sor_SoilModelResults_Opt_Text_FALSE_useDUL_TRUE_saturationLowerLevel_TRUE.RData

description: :unav
DOI: 10.25625/3dvvvn/ejpwxg
title: DE-Tha_SoilModelResults_Opt_Text_FALSE_useDUL_TRUE_saturationLowerLevel_FALSE.RData

description: :unav
DOI: 10.25625/3dvvvn/hy77ai
title: BE-Bra_SoilModelResults_Opt_Text_FALSE_useDUL_TRUE_saturationLowerLevel_FALSE.RData

description: :unav
DOI: 10.25625/3dvvvn/ipj2pk
title: IT-Lav_EffectOfDepth.png

description: :unav
DOI: 10.25625/3dvvvn/p5w6up
title: DE-Lnf_SoilModelResults_Opt_Text_FALSE_useDUL_TRUE_saturationLowerLevel_FALSE.RData

description: :unav
DOI: 10.25625/3dvvvn/udbwzi
title: US-Me2_SoilModelResults_Opt_Text_TRUE_useDUL_TRUE_saturationLowerLevel_TRUE.RData

description: :unav
DOI: 10.25625/3dvvvn/xnmtfh
title: ChangeNoOftimeSteps.RData

description: :unav
DOI: 10.5281/zenodo.3786820
title: Inputs for computational electrophysiology of the Glycine Receptor with GROMACS 19

description: Inputs for computational electrophysiology of the Glycine Receptor (D&B-open model, doi:10.5281/zenodo.3476169) with GROMACS 19 and the CHARMM36 force-field, using: 1- a single membrane system with the application of a constant electric field. 2- a double membrane system with the application of the charge imbalance protocol. The model of the glycine receptor was reduced to its transmembrane domain and simulated with atomic positional restraints. Related to the published article: "On the functional annotation of open-channel structures in the glycine receptor".
description: {"references": ["Adrien Henri Cerdan and Marco Cecchini (2020). On the functional annotation of open-channel structures in the glycine receptor."]}
DOI: 10.5281/zenodo.3786821
title: Inputs for computational electrophysiology of the Glycine Receptor with GROMACS 19

description: Inputs for computational electrophysiology of the Glycine Receptor (D&B-open model, doi:10.5281/zenodo.3476169) with GROMACS 19 and the CHARMM36 force-field, using: 1- a single membrane system with the application of a constant electric field. 2- a double membrane system with the application of the charge imbalance protocol. The model of the glycine receptor was reduced to its transmembrane domain and simulated with atomic positional restraints. Related to the published article: "On the functional annotation of open-channel structures in the glycine receptor".
description: {"references": ["Adrien Henri Cerdan and Marco Cecchini (2020). On the functional annotation of open-channel structures in the glycine receptor."]}
DOI: 10.25625/3dvvvn/7yhiel
title: DeHa2013_biljou_met.txt

description: :unav
DOI: 10.25625/3dvvvn/8apkfu
title: DeHa2012_biljou_met.txt

description: :unav
DOI: 10.25625/3dvvvn/9a2bv5
title: US-Syv_SoilModelResults_Opt_Text_TRUE_useDUL_FALSE_saturationLowerLevel_TRUE.RData

description: :unav
DOI: 10.25625/3dvvvn/cxkvl6
title: US-Me2_EffectOfDepth.png

description: :unav
DOI: 10.25625/3dvvvn/fixcdb
title: SiteCharacteristics.tab

description: :unav
DOI: 10.25625/3dvvvn/kgfdst
title: DeHa2018_biljou_met.txt

description: :unav
DOI: 10.25625/3dvvvn/mieirw
title: DE-Lnf.ObservedSoilMoisture.tab

description: :unav
DOI: 10.25625/3dvvvn/sb4iub
title: DE-Tha_SoilModelResults_Opt_Text_TRUE_useDUL_FALSE_saturationLowerLevel_FALSE.RData

description: :unav
DOI: 10.5281/zenodo.3787023
title: Preparation of thorium dioxide nanofibers by electrospinning_experimental dataset

description: This file contains the raw unprocessed experimental data for the results published in Kundrát et al., Preparation of thorium dioxide nanofibers by electrospinning, Journal of Nuclear Materials, Volume 534, June 2020, 152153. .
description: This research has been financially supported by the MEYS CR under the project CEITEC 2020 (LQ1601) and the Horizon 2020 Research and Innovation Program under the grant agreement no. 810626 (SINNCE). CIISB research infrastructure project LM2018127 funded by the MEYS CR is gratefully acknowledged for the financial support of the measurements at the CEITEC MU CF X-ray Diffraction and Bio-SAXS and the CF Cryo-electron Microscopy and Tomography.
DOI: 10.17632/nxs56ss7cf.7
title: Data for: Metabolomic profiling unveils similar cytotoxicities and protective functionality of quercetin of deoxynivalenol and 15-acetyl deoxynivalenol induced cell apoptosis

description: These data sets are the results of our research.
DOI: 10.17632/xddwncdg2v.2
title: Data for: Structural equation modeling applied to internet consumption forecast in Brazil

description: Variables Economic: Domestic credit to private sector; GDP; GDP per capita; Gross capital formation; Gross domestic income; Gross domestic savings; Gross national expenditure; Gross savings; Net investment in nonfinancial assets; Population, total; Unemployment rate (World Bank, 2019c) Innovation: R&D employees IBGE and Firms IBGE (2019c); Firms that spend on R&D (World Bank, 2019a), R&D expenditure, Researchers in R&D and Technicians in R&D (UNESCO, 2019); and Scientific and technical journal articles (NSF, 2019). Internet supply: Households with computers IBGE and Households connected to the internet IBGE (2019a); Fixed broadband subscriptions, Fixed telephone subscriptions and Individuals using the Internet (ITU, 2019). Technologic: Telecommunications employees, Telecommunications companies, Information and communications technology employees and Information and communications technology companies (IBGE, 2019c); Valores do Índice de Serviços de Telecomunicações (Anatel, 2019); Investment in ICT with private participation (World Bank, 2019b); Information and communication sector activity Index IBGE (2019b); High-technology exports (United Nations, 2019). Internet consumption: Internet consumption (ITU, 2018). References ANATEL (2019). Valores do Índice de Serviços de Telecomunicações (IST). Retrieved January 02, 2020, form https://anatel.gov.br/setorregulado/tarifas-e-precos/valores-do-indice-de-servicos-de-telecomunicacoes-ist. IBGE (2019a). Domicílios particulares permanentes (existência de microcomputador, acesso à Internet e tipo de telefone). Retrieved January 02, 2020, form https://sidra.ibge.gov.br/tabela/2387. IBGE (2019b). Série encadeada do índice de volume trimestral da atividade de informação e comunicação. Retrieved January 02, 2020, form https://sidra.ibge.gov.br/tabela/1620 IBGE (2019c). Unidades locais e pessoal ocupado por atividade. Retrieved January 02, 2020, form https://sidra.ibge.gov.br/tabela/988. ITU (2018). Measuring the Information Society Report 2017. Geneva: ITU. Retrieved January 02, 2020, form https://www.itu.int/en/ITU-D/Statistics/Documents/publications/misr2018/MISR-2018-Vol-1-E.pdf. ITU (2019). World Telecommunication/ICT Development Report and database. NSF (2019). Science and Engineering Indicators. Retrieved January 02, 2020, form https://www.nsf.gov/statistics. UNESCO (2019). Institute for Statistics, Science, Technology & Innovation. Retrieved January 02, 2020, form http://uis.unesco.org. United Nations (2019). Comtrade database through the WITS platform. Retrieved January 02, 2020, form https://comtrade.un.org. World Bank (2019a). Enterprise Surveys. Retrieved January 02, 2020, form http://www.enterprisesurveys.org. World Bank (2019b). Private Participation in Infrastructure Project Database. Retrieved January 02, 2020, form http://ppi.worldbank.org. World Bank (2019c). World Development Indicators. Retrieved January 02, 2020, form https://databank.worldbank.org/source/world-development-indicators.
DOI: 10.18112/openneuro.ds002778.v1.0.0
title: UC San Diego Resting State EEG Data from Patients with Parkinson's Disease
DOI: 10.25625/3dvvvn/7wpe2j
title: US-Syv_SoilModelResults_Opt_Text_FALSE_useDUL_TRUE_saturationLowerLevel_TRUE.RData

description: :unav
DOI: 10.25625/3dvvvn/kicrkb
title: growingSeasonCalc.Rmd

description: :unav
DOI: 10.25625/3dvvvn/l9u5lm
title: DE-Lnf_SoilModelResults_Opt_Text_FALSE_useDUL_FALSE_saturationLowerLevel_TRUE.RData

description: :unav
DOI: 10.25625/3dvvvn/lcideq
title: DE-Hai.SoilTextureDifferentStudies.tab

description: :unav
DOI: 10.25625/3dvvvn/p8koxs
title: GeneralSiteData_old.tab

description: :unav
DOI: 10.25625/3dvvvn/qvu8cj
title: US-MMS_SoilModelResults_Opt_Text_TRUE_useDUL_FALSE_saturationLowerLevel_FALSE.RData

description: :unav
DOI: 10.25625/3dvvvn/xebriv
title: US-Syv_EffectOfDepth.png

description: :unav
DOI: 10.25625/3dvvvn/yvbcci
title: UsingNewPET.png

description: :unav
DOI: 10.5281/zenodo.3787022
title: Preparation of thorium dioxide nanofibers by electrospinning_experimental dataset

description: This file contains the raw unprocessed experimental data for the results published in Kundrát et al., Preparation of thorium dioxide nanofibers by electrospinning, Journal of Nuclear Materials, Volume 534, June 2020, 152153. .
description: This research has been financially supported by the MEYS CR under the project CEITEC 2020 (LQ1601) and the Horizon 2020 Research and Innovation Program under the grant agreement no. 810626 (SINNCE). CIISB research infrastructure project LM2018127 funded by the MEYS CR is gratefully acknowledged for the financial support of the measurements at the CEITEC MU CF X-ray Diffraction and Bio-SAXS and the CF Cryo-electron Microscopy and Tomography.
DOI: 10.17632/3zy2f7zfy8.6
title: Data for: WHEN BASIC SUPPLIES ARE MISSING, WHAT TO DO? SPECIFIC DEMANDS OF THE LOCAL STREET POPULATION IN TIMES OF CORONAVIRUS – A CONCERN OF SOCIAL PSYCHIATRY

description: Homeless experts and some federal housing officials are sounding the alarm that the patchwork of government efforts to address the coronavirus outbreak risks leaving out one group of acutely vulnerable people: the homeless. In terms of isolation, it is too unclear what that looks like if you normally sleep on the streets. In this tough moment, when people should be turned away, not only it feels inhumane, but it is also a big public health risk, because where are they going to go? With more cities suspecting community transmission of the novel coronavirus, people who sleep in shelters or hunker down outside already have a lower life expectancy and often have underlying health conditions that put them at greater risk if they develop COVID-19. A large population of homeless people experience their pain and psychological distress intermittently. For low-income patients, the various borderline situations related to health/illness involve growing expectations regarding the basic needs. This is a serious concern when linked to the pandemic
DOI: 10.17632/sk9nptb76r.3
title: Efficacy of 755 nm Q-Switched Alexandrite Laser for Hori’s Nevus

description: 755 nm Q-Switched Alexandrite Laser benefits Hori’s Nevus
DOI: 10.17632/t4kvkg7cdt.5
title: Data for: PEOPLE EXPERIENCING HOMELESSNESS: THEIR POTENTIAL EXPOSURE TO COVID-19

description: Insufficient housing quality is associated with stress and mental health impacts. Homeless organizations have been sounding the alarm for weeks. They have been warning that the coronavirus could cause catastrophic harm to unhoused communities amid the absence of a coordinated strategy to aid people already struggling to survive in tents and overcrowded shelters. Depression and stress weaken our immune systems. Individuals with low incomes are disproportionately likely to suffer from poor mental health. As the coronavirus continues to unleash mayhem, we could be on an economic precipice.
DOI: 10.25625/3dvvvn/bpeapy
title: Fig_DK-Sor_Eval.jpeg

description: :unav
DOI: 10.25625/3dvvvn/jwzt6v
title: Fig_SMmeasurements.jpeg

description: :unav
DOI: 10.25625/3dvvvn/ktnv2x
title: US-MMS_SoilModelResults_Opt_Text_FALSE_useDUL_TRUE_saturationLowerLevel_FALSE.RData

description: :unav
DOI: 10.25625/3dvvvn/mi71zj
title: US-Syv_SoilModelResults_Opt_Text_FALSE_useDUL_FALSE_saturationLowerLevel_FALSE.RData

description: :unav
DOI: 10.25625/3dvvvn/ocaxsq
title: BE-Bra_SoilModelResults_Opt_Text_TRUE_useDUL_TRUE_saturationLowerLevel_TRUE.RData

description: :unav
DOI: 10.25625/3dvvvn/oru1ui
title: RegressionTemperature.R

description: :unav
DOI: 10.25625/3dvvvn/qlic6r
title: BE-Bra_SoilModelResults_Opt_Text_FALSE_useDUL_FALSE_saturationLowerLevel_TRUE.RData

description: :unav
DOI: 10.25625/3dvvvn/vwhgwu
title: US-Me2_SoilModelResults_Opt_Text_FALSE_useDUL_TRUE_saturationLowerLevel_TRUE.RData

description: :unav
DOI: 10.25625/3dvvvn/wgtsvz
title: DeHa2006_biljou_met.txt

description: :unav
DOI: 10.17632/rnk3pyk24g.1
title: Use of teledermatology by dermatology hospitalists is effective in the diagnosis and management of inpatient disease.

description: Supplemental figures and tables for "Use of teledermatology by dermatology hospitalists is effective in the diagnosis and management of inpatient disease."
DOI: 10.25625/3dvvvn/8gl660
title: Fig_DE-Tha_Eval.jpeg

description: :unav
DOI: 10.25625/3dvvvn/9v6kvu
title: DE-Tha_SoilModelResults_Opt_Text_FALSE_useDUL_FALSE_saturationLowerLevel_FALSE.RData

description: :unav
DOI: 10.25625/3dvvvn/apootu
title: BE-Vie_SoilModelResults_Opt_Text_FALSE_useDUL_TRUE_saturationLowerLevel_FALSE.RData

description: :unav
DOI: 10.25625/3dvvvn/frn90j
title: DE-Lnf_EffectOfDepth.png

description: :unav
DOI: 10.25625/3dvvvn/gqp0nz
title: US-UMBSoilModelData.RData

description: :unav
DOI: 10.25625/3dvvvn/jjhjr0
title: DeHa2011_biljou_met.txt

description: :unav
DOI: 10.25625/3dvvvn/nthuil
title: DeHa2006biljou_soil.txt

description: :unav
DOI: 10.25625/3dvvvn/vclgkl
title: DK-Sor_SoilModelResults_Opt_Text_TRUE_useDUL_TRUE_saturationLowerLevel_FALSE.RData

description: :unav
DOI: 10.17632/4gvjr85866.2
title: Research Article- Interaction of Cu(II) with Microtubule Binding Repeats of Tau Protein-A New Insight into the Molecular Mechanism of Alzheimer's Disease

description: Understanding the factors that give rise to tau aggregation and reactive oxygen species (ROS) is the key aspect of Alzheimer’s disease pathogenesis. Microtubule (MT) binding repeats of tau protein were suggested to play a critical role in tau aggregation. Here, we show that the interaction of Cu(II) with full-length MT binding repeats R1−R4 leads to the aggregation, and Cys-based redox chemistry is critically involved in tau aggregation leading to disulfide-bridge dimerization of R2 and R3 and further aggregation into a fibrillar structure. Notably, ascorbate and glutathione, the most abundant antioxidants in neurons, cannot prevent the effect of Cu(II) on R2 and R3 aggregation. Detailed ESI-MS and NMR experiments demonstrate the interaction of Cu(II) with MT binding repeats. We show that redox activity of copper increases when bound to the MT repeats leading to ROS formation, which significantly contributes to cellular damage and neuron death. Results presented here provide new insights into the molecular mechanism of tau aggregation and ROS formation and suggest a new target domain for tau aggregation inhibitors. References: (1) Ahmadi, S.; Wu, B.; Song, R.; Zhu, S.; Simpson, A.; Wilson, D. J.; Kraatz, H. B. Exploring the Interactions of Iron and Zinc with the Microtubule Binding Repeats R1 and R4. J. Inorg. Biochem. 2020, 205, 110987. https://doi.org/10.1016/j.jinorgbio.2019.110987. (2)Ahmadi, S.; Zhu, S.; Sharma, R.; Wilson, D. J.; Kraatz, H.-B. Interaction of Metal Ions with Tau Protein. The Case for a Metal-Mediated Tau Aggregation. J. Inorg. Biochem. 2019, 194, 44–51. (3) Ahmadi, S.; Ebralidze, I. I.; She, Z.; Kraatz, H.-B. Electrochemical Studies of Tau Protein-Iron Interactions—Potential Implications for Alzheimer’s Disease. Electrochim. Acta 2017, 236, 384–393. https://doi.org/10.1016/j.electacta.2017.03.175.