cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.8987795
title: Heart Failure with Mid-Range Ejection Fraction - State of the Art

description: Abstract In 2016, the European Society of Cardiology (ESC) recognized heart failure (HF) with ejection fraction between 40 and 49% as a new HF phenotype, HF with mid-range ejection fraction (HFmrEF), with the main purpose of encouraging studies on this new category. In 2018, the Brazilian Society of Cardiology adhered to this classification and introduced HFmrEF in Brazil. This paper presents a narrative review of what the literature has described about HFmrEF. The prevalence of patients with HFmrEF ranged from 13 to 24% of patients with HF. Analyzing the clinical characteristics, HFmrEF shows intermediate characteristics or is either similar to HF with preserved ejection fraction (HFpEF) or to HF with reduced fraction (HFrEF). Regarding the prognosis, HFmrEF’s all-cause mortality is similar to HFpEF’s and lower than HFrEF’s. Studies that analyzed cardiac mortality concluded that there was no significant difference between HFmrEF and HFrEF, both of which were lower than HFpEF. Despite the significant increase of publications on HFmrEF, there is a great scarcity of prospective studies and clinical trials that allow delineating specific therapies for this new phenotype. To better treat HFmrEF patients, it is fundamental that cardiologists and internists understand the differences and similarities of this new phenotype.
DOI: 10.6084/m9.figshare.8987801.v1
title: Sympatho-Vagal Imbalance is Associated with Sarcopenia in Male Patients with Heart Failure

description: Abstract Background: Resting sympathetic hyperactivity and impaired parasympathetic reactivation after exercise have been described in patients with heart failure (HF). However, the association of these autonomic changes in patients with HF and sarcopenia is unknown. Objective: The aim of this study was to evaluate the impact of autonomic modulation on sarcopenia in male patients with HF. Methods: We enrolled 116 male patients with HF and left ventricular ejection fraction &lt; 40%. All patients underwent a maximal cardiopulmonary exercise testing. Maximal heart rate was recorded and delta heart rate recovery (∆HRR) was assessed at 1st and 2nd minutes after exercise. Muscle sympathetic nerve activity (MSNA) was recorded by microneurography. Dual-energy X-ray absorptiometry was used to measure body composition and sarcopenia was defined by the sum of appendicular lean muscle mass (ALM) divided by height in meters squared and handgrip strength. Results: Sarcopenia was identified in 33 patients (28%). Patients with sarcopenia had higher MSNA than those without (47 [41-52] vs. 40 [34-48] bursts/min, p = 0.028). Sarcopenic patients showed lower ∆HRR at 1st (15 [10-21] vs. 22 [16-30] beats/min, p &lt; 0.001) and 2nd min (25 [19-39] vs. 35 [24-48] beats/min, p = 0.017) than non-sarcopenic. There was a positive correlation between ALM and ∆HRR at 1st (r = 0.26, p = 0.008) and 2nd min (r = 0.25, p = 0.012). We observed a negative correlation between ALM and MSNA (r = -0.29, p = 0.003). Conclusion: Sympatho-vagal imbalance seems to be associated with sarcopenia in male patients with HF. These results highlight the importance of a therapeutic approach in patients with muscle wasting and increased peripheral sympathetic outflow.
DOI: 10.6084/m9.figshare.8987792
title: Genetic evidence of multiple reproductive strategies in a microendemic and threatened cactus (Cactaceae: Discocactus Pfeiff) in Bahia, Brazil

description: ABSTRACT Discocactus zehntneri subsp. petr-halfari, an endangered taxon, is represented by a single population in an anthropized area of Bahia, Brazil, where it is suffering due to extreme extractivism. Thus, information about this cactus, such as its reproductive patterns, is urgently needed to support conservation strategies. A population genetics approach was used to determine if this subspecies has a preferential pattern of reproduction. We sampled 18 individuals, both with and without connection to parental plants, from five clumps and assessed their diversity and genetic structure using five ISSR markers. The results revealed two clumps that are genetically supported by the presence of genetically equal individuals. The other three groups presented individuals that are genetically different and similar to individuals in other clumps. These findings suggest that this subspecies has sexual and clonal reproduction and that its environmental distribution might be shaped by events of dispersion. In addition, a possible hybrid origin may explain its rates of genetic diversity. Despite all these factors, this taxon is in danger and so the development of conservation strategies to preserve its population are urgently needed, including in situ and ex situ actions such as the micropropagation in vitro, living collections and cryopreservation.
DOI: 10.6084/m9.figshare.8987798.v1
title: Utilization of bedded cattle confinement for organic manure of maize crop

description: ABSTRACT The use of organic wastes from housing systems in a compost bedded pack barn model could supply much of the fertiliser demand in the farm. Moreover, with the increase in food consumption from sustainable livestock, the use of compost generated in the farm itself becomes economically viable. This study aimed to evaluate the effect of organic manure from bedded cattle confinement applied at different moments on maize crop. The experiment was carried out in a randomized blocks with five treatments and five repetitions. The data were submitted to analysis of variance and the means were compared by Scott-Knott test at p ≤ 0.05. The treatments with addition of fresh compost and mature compost with nitrogen cover had higher production of maize shoot dry matter when compared to treatments without compost. For all variables analysed, the treatments with compost were superior to the other ones. The soil used for growing silage maize has improved considerably its chemical characteristics when the compost was applied. The use of bedding material compost from sheds as organic manure is recommended as a sustainable alternative in the reuse and treatment of waste from cattle confinement farm.
DOI: 10.6084/m9.figshare.8987789
title: LIGHT N-PARAFFINS SEPARATION BY INVERSE GAS CHROMATOGRAPHY WITH CUBAN VOLCANIC GLASS

description: ABSTRACT In this work the applicability of a natural volcanic glass (technological type I material) from Cuba is investigated as adsorbent for separation of mixtures of C1-(C5; C6; C7; C8; C9) hydrocarbons by inverse gas chromatography under ﬂow conditions in a temperature range of 328-343 K. The experimental results indicated that the material was mainly composed of silica and, in a lower proportion, of alumina, that provided surface Si-OH and Al-OH groups to favor the interaction and separation of the different components of paraffin mixtures. In fact, the calculated heats of adsorption were high enough to facilitate the separation procedure. The high availability and low cost of these materials make them potential and attractive candidates to be used in large scale applications.
DOI: 10.6084/m9.figshare.8987792.v1
title: Genetic evidence of multiple reproductive strategies in a microendemic and threatened cactus (Cactaceae: Discocactus Pfeiff) in Bahia, Brazil

description: ABSTRACT Discocactus zehntneri subsp. petr-halfari, an endangered taxon, is represented by a single population in an anthropized area of Bahia, Brazil, where it is suffering due to extreme extractivism. Thus, information about this cactus, such as its reproductive patterns, is urgently needed to support conservation strategies. A population genetics approach was used to determine if this subspecies has a preferential pattern of reproduction. We sampled 18 individuals, both with and without connection to parental plants, from five clumps and assessed their diversity and genetic structure using five ISSR markers. The results revealed two clumps that are genetically supported by the presence of genetically equal individuals. The other three groups presented individuals that are genetically different and similar to individuals in other clumps. These findings suggest that this subspecies has sexual and clonal reproduction and that its environmental distribution might be shaped by events of dispersion. In addition, a possible hybrid origin may explain its rates of genetic diversity. Despite all these factors, this taxon is in danger and so the development of conservation strategies to preserve its population are urgently needed, including in situ and ex situ actions such as the micropropagation in vitro, living collections and cryopreservation.
DOI: 10.6084/m9.figshare.8987795.v1
title: Heart Failure with Mid-Range Ejection Fraction - State of the Art

description: Abstract In 2016, the European Society of Cardiology (ESC) recognized heart failure (HF) with ejection fraction between 40 and 49% as a new HF phenotype, HF with mid-range ejection fraction (HFmrEF), with the main purpose of encouraging studies on this new category. In 2018, the Brazilian Society of Cardiology adhered to this classification and introduced HFmrEF in Brazil. This paper presents a narrative review of what the literature has described about HFmrEF. The prevalence of patients with HFmrEF ranged from 13 to 24% of patients with HF. Analyzing the clinical characteristics, HFmrEF shows intermediate characteristics or is either similar to HF with preserved ejection fraction (HFpEF) or to HF with reduced fraction (HFrEF). Regarding the prognosis, HFmrEF’s all-cause mortality is similar to HFpEF’s and lower than HFrEF’s. Studies that analyzed cardiac mortality concluded that there was no significant difference between HFmrEF and HFrEF, both of which were lower than HFpEF. Despite the significant increase of publications on HFmrEF, there is a great scarcity of prospective studies and clinical trials that allow delineating specific therapies for this new phenotype. To better treat HFmrEF patients, it is fundamental that cardiologists and internists understand the differences and similarities of this new phenotype.
DOI: 10.6084/m9.figshare.8987786
title: SIMULATION OF THERMAL DECOMPOSITION IN AN OPEN CAVITY: ENTROPY ANALYSIS

description: ABSTRACT This paper presents a numerical analysis of entropy generation in a two-dimensional rectangular channel where the inlet flow undergoes thermal decomposition resulting from a chemical reaction. The model considered viscosity and thermal conductivity to be dependent of temperature. Irreversibility due to mass transport was included in the entropy generation analysis. Relevant applications of this study are possible for the design of power generation systems and reactors. The effects of the Reynolds number, Schmidt number, and length of the heat source on thermal fluid dynamics, mass transfer, and irreversibility were also investigated. It was found that thermal decomposition increases at: a) low Reynolds numbers, b) low Schmidt numbers, and c) increased length of heat source. Additionally, overall entropy generation increased when Reynolds number and length of heat source were increased, although in all cases, overall irreversibility attains a minimum value at a specific Schmidt number.
DOI: 10.6084/m9.figshare.8987789.v1
title: LIGHT N-PARAFFINS SEPARATION BY INVERSE GAS CHROMATOGRAPHY WITH CUBAN VOLCANIC GLASS

description: ABSTRACT In this work the applicability of a natural volcanic glass (technological type I material) from Cuba is investigated as adsorbent for separation of mixtures of C1-(C5; C6; C7; C8; C9) hydrocarbons by inverse gas chromatography under ﬂow conditions in a temperature range of 328-343 K. The experimental results indicated that the material was mainly composed of silica and, in a lower proportion, of alumina, that provided surface Si-OH and Al-OH groups to favor the interaction and separation of the different components of paraffin mixtures. In fact, the calculated heats of adsorption were high enough to facilitate the separation procedure. The high availability and low cost of these materials make them potential and attractive candidates to be used in large scale applications.
DOI: 10.6084/m9.figshare.8987783
title: SYNTHESIS, CHARACTERIZATION AND in vitro CYTOTOXICITY OF Acacia mearnsii PROANTHOCYANIDIN LOADED PLGA MICROPARTICLES

description: ABSTRACT One of the highlighted areas in the development of new materials is the generation of micro- and nanoparticles as drug carriers which allow the progress in formulations with the ability to release active agents in a controlled way. The proanthocyanidins (PAC) extracted from the bark of the Black Wattle have stood out for their biological activities. However, most polyflavonoids have some features which limit their application in the pharmaceutical field, such as light fastness, low bioavailability of active agents, and unpleasant taste. In this context, this study aims to present the synthesis and characterization of PAC-loaded lactic-co-glycolic acid (PLGA) microparticles obtained by the multiple emulsion method. The incorporation of PAC into PLGA was successfully achieved with PAC encapsulation efficiency around 73%. Spherical microparticles were obtained with a size distribution in the range of 0.6 to 2.4 μm. The presence of PAC modified the thermal properties of the PLGA matrix. The results of in vitro assays with Vero and T24 lineage celss showed that PLGA/PAC microparticles did not promote any effect on cell proliferation by MTT assay after 24 h. The novel Acacia mearnsii proanthocyanidin-loaded PLGA microparticles have potential for application in biological systems.
DOI: 10.6084/m9.figshare.8987777
title: Microbial Profile and Endotoxin Levels in Primary Periodontal Lesions with Secondary Endodontic Involvement

description: Abstract This study was carried out to investigate the microbial profile and endotoxin levels of endodontic-periodontal lesions of periodontal origin. Periodontal and endodontic samples were taken from periodontal pockets and necrotic root canals of 10 teeth with endodontic-periodontal lesions. Evidencing of 40 different bacterial species were determined in each endodontic and periodontal sample using the checkerboard DNA-DNA hybridization method and Kinetic chromogenic LAL assay was used for quantification of endotoxins. Fisher’s exact test correlated the bacterial species with the endodontic or periodontal microbiota. The endotoxin levels (EU/mL) found in samples of the root canal and periodontal pocket were compared by the Wilcoxon test (p&lt;0.05). Bacteria and LPS units were found in 100% of the endodontic and periodontal samples. The species E. faecium, P. acnes, G. morbillorum, C. sputigena and L. buccalis were strongly correlated with the endodontic microbiota and P. nigrescens with the periodontal microbiota. P. intermedia, P. endodontalis and V. parvula were more prevalent in both endodontic and periodontal microbiots. The endotoxin levels in the periodontal pocket (89600 EU/mL) were significantly higher than in the root canal (2310 EU/mL). It was concluded that the microbiota present in the periodontal and endodontic tissues is similar, with a higher prevalence of species of the orange complex and a higher level of endotoxin in the periodontal pockets.
DOI: 10.6084/m9.figshare.8987780
title: The Signs of alert and Labor: knowledge among pregnant women

description: Abstract Objectives: ididentify the scores on the pregnant women’s knowledge on the signs of alert and labor and correlate the scores with the maternal age, number of children and the guidance they received during pregnancy. Methods: this is a descriptive, cross-sectional study with a quantitative approach on pregnant women's previous knowledge of the signs of alert and labor performed with 100 pregnant women on their 30th week of gestation at the Hospital de Clínicas da UFTM (Clinical Hospital). The data collection was carried out from April to June 2016, using a semi-structured instrument tested as a pilot study. Results: only 21% of the pregnant women reported taking part in the pregnant women's group; 61% of them referred to not receiving any information on the signs of alert and labor. A statistically significant association was verified between the number of correct answers and the guidance they received during prenatal consultations. However, there was no correlation between the correct scores on maternal age and the number of children. Conclusions: the pregnant women who did not receive any kind of guidance, they had lower scores on the correct answers, which shows the importance of guiding them about Health Education during their prenatal consultations.
DOI: 10.6084/m9.figshare.8987786.v1
title: SIMULATION OF THERMAL DECOMPOSITION IN AN OPEN CAVITY: ENTROPY ANALYSIS

description: ABSTRACT This paper presents a numerical analysis of entropy generation in a two-dimensional rectangular channel where the inlet flow undergoes thermal decomposition resulting from a chemical reaction. The model considered viscosity and thermal conductivity to be dependent of temperature. Irreversibility due to mass transport was included in the entropy generation analysis. Relevant applications of this study are possible for the design of power generation systems and reactors. The effects of the Reynolds number, Schmidt number, and length of the heat source on thermal fluid dynamics, mass transfer, and irreversibility were also investigated. It was found that thermal decomposition increases at: a) low Reynolds numbers, b) low Schmidt numbers, and c) increased length of heat source. Additionally, overall entropy generation increased when Reynolds number and length of heat source were increased, although in all cases, overall irreversibility attains a minimum value at a specific Schmidt number.
DOI: 10.6084/m9.figshare.8987771
title: Prevalence and determinants of the use of pacifiers and feedingbottle: a study in Southwest Bahia

description: Abstract Objectives: to assess the use of pacifier and feedingbottle and their determinants in children from a municipality of Southwest Bahia. Methods: a cross-sectional study was performed with 354 children younger than 12 months old. The event was categorized in: exclusive use of pacifier, exclusive use of feeding bottle,use of pacifier and feeding bottle, and not use any of them. Multinomial analysis with logistic regression was applied, and those who did not use any artificial nipples were thereference variable. Results: it was observed that 11.9% of the children exclusively used pacifiers, 21.2% only use bottles and 32.8% used both of them. The following factors were associated with the exclusive use of pacifiers: low maternal schooling level (eight or less years of education), lack of previous experience with breastfeeding, difficulty in postpartum breastfeeding, and lack of incentive to breastfeeding in puericulture. The exclusive use of feeding bottle was associated with unmarried mothers, aged 35 years old or older, and with less years of education (eight or less years). Women who worked outside home and had difficulty in breastfeeding had greater chance of giving both artificial nipples to the children. Conclusions: the findingspresent different featuresrelated to the exclusive or combined use of pacifiers and feeding bottles, being important to direct health professionals conducts towards mothers’ orientation.
DOI: 10.6084/m9.figshare.8987780.v1
title: The Signs of alert and Labor: knowledge among pregnant women

description: Abstract Objectives: ididentify the scores on the pregnant women’s knowledge on the signs of alert and labor and correlate the scores with the maternal age, number of children and the guidance they received during pregnancy. Methods: this is a descriptive, cross-sectional study with a quantitative approach on pregnant women's previous knowledge of the signs of alert and labor performed with 100 pregnant women on their 30th week of gestation at the Hospital de Clínicas da UFTM (Clinical Hospital). The data collection was carried out from April to June 2016, using a semi-structured instrument tested as a pilot study. Results: only 21% of the pregnant women reported taking part in the pregnant women's group; 61% of them referred to not receiving any information on the signs of alert and labor. A statistically significant association was verified between the number of correct answers and the guidance they received during prenatal consultations. However, there was no correlation between the correct scores on maternal age and the number of children. Conclusions: the pregnant women who did not receive any kind of guidance, they had lower scores on the correct answers, which shows the importance of guiding them about Health Education during their prenatal consultations.
DOI: 10.6084/m9.figshare.8987768
title: Postprandial metabolic effects of fructose and glucose in type 1 diabetes patients: a pilot randomized crossover clinical trial

description: ABSTRACT Objective To test the influence of oral fructose and glucose dose-response solutions in blood glucose (BG), glucagon, triglycerides, uricaemia, and malondialdehyde in postprandial states in type 1 diabetes mellitus (T1DM) patients. Subjects and methods The study had a simple-blind, randomized, two-way crossover design in which T1DM patients were selected to receive fructose and glucose solutions (75g of sugars dissolved in 200 mL of mineral-water) in two separate study days, with 2-7 weeks washout period. In each day, blood samples were drawn after 8h fasting and at 180 min postprandial to obtain glucose, glucagon, triglycerides, uric acid, lactate, and malondialdehyde levels. Results Sixteen T1DM patients (seven men) were evaluated, with a mean age of 25.19 ± 8.8 years, a mean duration of disease of 14.88 ± 4.73 years, and glycated hemoglobin of 8.13 ± 1.84%. Fructose resulted in lower postprandial BG levels than glucose (4.4 ± 5.5 mmol/L; and 12.9 ± 4.1 mmol/L, respectively; p &lt; 0.01). Uric acid levels increased after fructose (26.1 ± 49.9 µmol/L; p &lt; 0.01) and reduced after glucose (-13.6 ± 9.5 µmol/L; p &lt; 0.01). The malondialdehyde increased after fructose (1.4 ± 1.6 µmol/L; p &lt; 0.01) and did not change after glucose solution (-0.2 ± 1.6 µmol/L; p = 0.40). Other variables did not change. Conclusions Fructose and glucose had similar sweetness, flavor and aftertaste characteristics and did not change triglycerides, lactate or glucagon levels. Although fructose resulted in lower postprandial BG than glucose, it increased uric acid and malondialdehyde levels in T1DM patients. Therefore it should be used with caution. ClinicalTrials.gov registration: NCT01713023.
DOI: 10.6084/m9.figshare.8987771.v1
title: Prevalence and determinants of the use of pacifiers and feedingbottle: a study in Southwest Bahia

description: Abstract Objectives: to assess the use of pacifier and feedingbottle and their determinants in children from a municipality of Southwest Bahia. Methods: a cross-sectional study was performed with 354 children younger than 12 months old. The event was categorized in: exclusive use of pacifier, exclusive use of feeding bottle,use of pacifier and feeding bottle, and not use any of them. Multinomial analysis with logistic regression was applied, and those who did not use any artificial nipples were thereference variable. Results: it was observed that 11.9% of the children exclusively used pacifiers, 21.2% only use bottles and 32.8% used both of them. The following factors were associated with the exclusive use of pacifiers: low maternal schooling level (eight or less years of education), lack of previous experience with breastfeeding, difficulty in postpartum breastfeeding, and lack of incentive to breastfeeding in puericulture. The exclusive use of feeding bottle was associated with unmarried mothers, aged 35 years old or older, and with less years of education (eight or less years). Women who worked outside home and had difficulty in breastfeeding had greater chance of giving both artificial nipples to the children. Conclusions: the findingspresent different featuresrelated to the exclusive or combined use of pacifiers and feeding bottles, being important to direct health professionals conducts towards mothers’ orientation.