cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.1279394.v190
title: Early ovariectomy reveals the germline encoding of the “natural” mammalian anti-A-reactive IgM reflecting developmental malignancy.

description: The germline encoding of a non-immune immunoglobulin M (IgM) molecule in mammals was experimentally documented for the first time as a result of the specifically timed ovariectomy of C57BL/10 mice. The target of this innate antibody involves a trans-species developmental antigen that signifies malignancy when expressed in any non-developmental tissue. Although ovariectomy and castration result in uncontrolled and/or enhanced humoral and cellular immunity involving increased weights of the spleen and thymus with pronounced B and T cell production, the development of mercaptoethanol-sensitive, complement-binding, non-immune anti-A reactivity in murine plasma was not enhanced after an ovariectomy that was performed in C57BL/10 mice prior to the onset of puberty. This non-immune murine anti-A, which is complementary to the trans-species, syngeneic ovarian GalNAc-glycan-bearing glycolipids and distinct from the cross-reactive adaptive anti-A antibody, was strongly downregulated or did not appear in plasma of animals ovariectomized at the age of 20 days. Thus, contrary to our previous view, this reactivity is unlikely to originate from a somatic, primary immune or autoimmune response. All of the murine tissues expressed the species-specific Forssman<i> </i>reactivity, and further A-like structures were identified in the male and female reproductive and endodermal organs by reaction with innate human anti-A antibody, while the murine anti-A was exclusively inhibited by syngeneic ovarian glycolipids. Moreover, the early ovarian tissue, which represents a last evolutionary and/or developmental location, showed a developmental polymorphism characterized by reactivity to the lectin from <i>Dolichos biflorus</i> and the agglutinin from <i>Helix pomatia </i>indicating the functional involvement of the <i>O</i>-GalNAc-determined mucin-type A-like, Tn- and Thomsen-Friedenreich (TF) epitopes that signify malignancy when accumulated and expressed in non-developmental tissues.
DOI: 10.6084/m9.figshare.1279394.v191
title: Early ovariectomy reveals the germline encoding of the “natural” mammalian anti-A-reactive IgM reflecting developmental malignancy.

description: The germline encoding of a non-immune immunoglobulin M (IgM) molecule in mammals was experimentally documented for the first time as a result of the specifically timed ovariectomy of C57BL/10 mice. The target of this innate antibody involves a trans-species developmental antigen that signifies malignancy when expressed in any non-developmental tissue. Although ovariectomy and castration result in uncontrolled and/or enhanced humoral and cellular immunity involving increased weights of the spleen and thymus with pronounced B and T cell production, the development of mercaptoethanol-sensitive, complement-binding, non-immune anti-A reactivity in murine plasma was not enhanced after an ovariectomy that was performed in C57BL/10 mice prior to the onset of puberty. This non-immune murine anti-A, which is complementary to the trans-species, syngeneic ovarian GalNAc-glycan-bearing glycolipids and distinct from the cross-reactive adaptive anti-A antibody, was strongly downregulated or did not appear in plasma of animals ovariectomized at the age of 20 days. Thus, contrary to our previous view, this reactivity is unlikely to originate from a somatic, primary immune or autoimmune response. All of the murine tissues expressed the species-specific Forssman<i> </i>reactivity, and further A-like structures were identified in the male and female reproductive and endodermal organs by reaction with innate human anti-A antibody, while the murine anti-A was exclusively inhibited by syngeneic ovarian glycolipids. Moreover, the early ovarian tissue, which represents a last evolutionary and/or developmental location, showed a developmental polymorphism characterized by reactivity to the lectin from <i>Dolichos biflorus</i> and the agglutinin from <i>Helix pomatia </i>indicating the functional involvement of the <i>O</i>-GalNAc-determined mucin-type A-like, Tn- and Thomsen-Friedenreich (TF) epitopes that signify malignancy when accumulated and expressed in non-developmental tissues.
DOI: 10.6084/m9.figshare.1270345.v1
title: Decomposing the misery index: A dynamic approach

description: The misery index (the unweighted sum of unemployment and inflation rates) was probably the first attempt to develop a single statistic to measure the level of a population’s economic malaise. In this letter, we develop a dynamic approach to decompose the misery index using two basic relations of modern macroeconomics: the expectations-augmented Phillips curve and Okun’s law. Our reformulation of the misery index is closer in spirit to Okun’s idea. However, we are able to offer an improved version of the index, mainly based on output and unemployment. Specifically, this new Okun’s index measures the level of economic discomfort as a function of three key factors: (1) the misery index in the previous period; (2) the output gap in growth rate terms; and (3) cyclical unemployment. This dynamic approach differs substantially from the standard one utilised to develop the misery index, and allow us to obtain an index with five main interesting features: (1) it focuses on output, unemployment and inflation; (2) it considers only objective variables; (3) it allows a distinction between short-run and long-run phenomena; (4) it places more importance on output and unemployment rather than inflation; and (5) it weights recessions more than expansions.
DOI: 10.6084/m9.figshare.1270345.v3
title: Decomposing the misery index: A dynamic approach

description: The misery index (the unweighted sum of unemployment and inflation rates) was probably the first attempt to develop a single statistic to measure the level of a population’s economic malaise. In this letter, we develop a dynamic approach to decompose the misery index using two basic relations of modern macroeconomics: the expectations-augmented Phillips curve and Okun’s law. Our reformulation of the misery index is closer in spirit to Okun’s idea. However, we are able to offer an improved version of the index, mainly based on output and unemployment. Specifically, this new Okun’s index measures the level of economic discomfort as a function of three key factors: (1) the misery index in the previous period; (2) the output gap in growth rate terms; and (3) cyclical unemployment. This dynamic approach differs substantially from the standard one utilised to develop the misery index, and allow us to obtain an index with five main interesting features: (1) it focuses on output, unemployment and inflation; (2) it considers only objective variables; (3) it allows a distinction between short-run and long-run phenomena; (4) it places more importance on output and unemployment rather than inflation; and (5) it weights recessions more than expansions.
DOI: 10.6084/m9.figshare.1279394.v192
title: Early ovariectomy reveals the germline encoding of the “natural” mammalian anti-A-reactive IgM reflecting developmental malignancy.

description: The germline encoding of a non-immune immunoglobulin M (IgM) molecule in mammals was experimentally documented for the first time as a result of the specifically timed ovariectomy of C57BL/10 mice. The target of this innate antibody involves a trans-species developmental antigen that signifies malignancy when expressed in any non-developmental tissue. Although ovariectomy and castration result in uncontrolled and/or enhanced humoral and cellular immunity involving increased weights of the spleen and thymus with pronounced B and T cell production, the development of mercaptoethanol-sensitive, complement-binding, non-immune anti-A reactivity in murine plasma was not enhanced after an ovariectomy that was performed in C57BL/10 mice prior to the onset of puberty. This non-immune murine anti-A, which is complementary to the trans-species, syngeneic ovarian GalNAc-glycan-bearing glycolipids and distinct from the cross-reactive adaptive anti-A antibody, was strongly downregulated or did not appear in plasma of animals ovariectomized at the age of 20 days. Thus, contrary to our previous view, this reactivity is unlikely to originate from a somatic, primary immune or autoimmune response. All of the murine tissues expressed the species-specific Forssman<i> </i>reactivity, and further A-like structures were identified in the male and female reproductive and endodermal organs by reaction with innate human anti-A antibody, while the murine anti-A was exclusively inhibited by syngeneic ovarian glycolipids. Moreover, the early ovarian tissue, which represents a last evolutionary and/or developmental location, showed a developmental polymorphism characterized by reactivity to the lectin from <i>Dolichos biflorus</i> and the agglutinin from <i>Helix pomatia </i>indicating the functional involvement of the <i>O</i>-GalNAc-determined mucin-type A-like, Tn- and Thomsen-Friedenreich (TF) epitopes that signify malignancy when accumulated and expressed in non-developmental tissues.
DOI: 10.6084/m9.figshare.1270345.v2
title: Decomposing the misery index: A dynamic approach

description: The misery index (the unweighted sum of unemployment and inflation rates) was probably the first attempt to develop a single statistic to measure the level of a population’s economic malaise. In this letter, we develop a dynamic approach to decompose the misery index using two basic relations of modern macroeconomics: the expectations-augmented Phillips curve and Okun’s law. Our reformulation of the misery index is closer in spirit to Okun’s idea. However, we are able to offer an improved version of the index, mainly based on output and unemployment. Specifically, this new Okun’s index measures the level of economic discomfort as a function of three key factors: (1) the misery index in the previous period; (2) the output gap in growth rate terms; and (3) cyclical unemployment. This dynamic approach differs substantially from the standard one utilised to develop the misery index, and allow us to obtain an index with five main interesting features: (1) it focuses on output, unemployment and inflation; (2) it considers only objective variables; (3) it allows a distinction between short-run and long-run phenomena; (4) it places more importance on output and unemployment rather than inflation; and (5) it weights recessions more than expansions.
DOI: 10.6084/m9.figshare.1279394.v193
title: Early ovariectomy reveals the germline encoding of the “natural” mammalian anti-A-reactive IgM reflecting developmental malignancy.

description: The germline encoding of a non-immune immunoglobulin M (IgM) molecule in mammals was experimentally documented for the first time as a result of the specifically timed ovariectomy of C57BL/10 mice. The target of this innate antibody involves a trans-species developmental antigen that signifies malignancy when expressed in any non-developmental tissue. Although ovariectomy and castration result in uncontrolled and/or enhanced humoral and cellular immunity involving increased weights of the spleen and thymus with pronounced B and T cell production, the development of mercaptoethanol-sensitive, complement-binding, non-immune anti-A reactivity in murine plasma was not enhanced after an ovariectomy that was performed in C57BL/10 mice prior to the onset of puberty. This non-immune murine anti-A, which is complementary to the trans-species, syngeneic ovarian GalNAc-glycan-bearing glycolipids and distinct from the cross-reactive adaptive anti-A antibody, was strongly downregulated or did not appear in plasma of animals ovariectomized at the age of 20 days. Thus, contrary to our previous view, this reactivity is unlikely to originate from a somatic, primary immune or autoimmune response. All of the murine tissues expressed the species-specific Forssman<i> </i>reactivity, and further A-like structures were identified in the male and female reproductive and endodermal organs by reaction with innate human anti-A antibody, while the murine anti-A was exclusively inhibited by syngeneic ovarian glycolipids. Moreover, the early ovarian tissue, which represents a last evolutionary and/or developmental location, showed a developmental polymorphism characterized by reactivity to the lectin from <i>Dolichos biflorus</i> and the agglutinin from <i>Helix pomatia </i>indicating the functional involvement of the <i>O</i>-GalNAc-determined mucin-type A-like, Tn- and Thomsen-Friedenreich (TF) epitopes that signify malignancy when accumulated and expressed in non-developmental tissues.
DOI: 10.6084/m9.figshare.1270272
title: Drug testing database

description: <em>Dec 13, 2014. </em> <strong>Drug testing database:</strong> ClinicalTrials.gov ―24640 found for 'drug testing' (Search Date: Dec 13, 2014). More data will be added to this figshare article in the future. <em>Analysis will be disclosed in any or all of these sites:</em> fig<strong>share</strong>, disruptedphysician.com, chaoticpharmacology.com, or a peer-review medical journal. This database complies with terms and conditions of ClinicalTrials.gov: http://clinicaltrials.gov/ct2/about-site/terms-conditions
DOI: 10.6084/m9.figshare.1270272.v1
title: Drug testing database

description: <em>Dec 13, 2014. </em> <strong>Drug testing database:</strong> ClinicalTrials.gov ―24640 found for 'drug testing' (Search Date: Dec 13, 2014). More data will be added to this figshare article in the future. <em>Analysis will be disclosed in any or all of these sites:</em> fig<strong>share</strong>, disruptedphysician.com, chaoticpharmacology.com, or a peer-review medical journal. This database complies with terms and conditions of ClinicalTrials.gov: http://clinicaltrials.gov/ct2/about-site/terms-conditions
DOI: 10.6084/m9.figshare.1279394.v194
title: Early ovariectomy reveals the germline encoding of the “natural” mammalian anti-A-reactive IgM reflecting developmental malignancy.

description: The germline encoding of a non-immune immunoglobulin M (IgM) molecule in mammals was experimentally documented for the first time as a result of the specifically timed ovariectomy of C57BL/10 mice. The target of this innate antibody involves a trans-species developmental antigen that signifies malignancy when expressed in any non-developmental tissue. Although ovariectomy and castration result in uncontrolled and/or enhanced humoral and cellular immunity involving increased weights of the spleen and thymus with pronounced B and T cell production, the development of mercaptoethanol-sensitive, complement-binding, non-immune anti-A reactivity in murine plasma was not enhanced after an ovariectomy that was performed in C57BL/10 mice prior to the onset of puberty. This non-immune murine anti-A, which is complementary to the trans-species, syngeneic ovarian GalNAc-glycan-bearing glycolipids and distinct from the cross-reactive adaptive anti-A antibody, was strongly downregulated or did not appear in plasma of animals ovariectomized at the age of 20 days. Thus, contrary to our previous view, this reactivity is unlikely to originate from a somatic, primary immune or autoimmune response. All of the murine tissues expressed the species-specific Forssman<i> </i>reactivity, and further A-like structures were identified in the male and female reproductive and endodermal organs by reaction with innate human anti-A antibody, while the murine anti-A was exclusively inhibited by syngeneic ovarian glycolipids. Moreover, the early ovarian tissue, which represents a last evolutionary and/or developmental location, showed a developmental polymorphism characterized by reactivity to the lectin from <i>Dolichos biflorus</i> and the agglutinin from <i>Helix pomatia </i>indicating the functional involvement of the <i>O</i>-GalNAc-determined mucin-type A-like, Tn- and Thomsen-Friedenreich (TF) epitopes that signify malignancy when accumulated and expressed in non-developmental tissues.
DOI: 10.6084/m9.figshare.1270074
title: Identification and bioactivity of the growth inhibitors in <i>Tuber</i> spp. methanolic extracts

description: The methanolic extracts of fresh fruiting bodies of <i>Tuber melanosporum</i>, <i>T. aestivum</i>, <i>T. magnatum</i> and <i>T. borchii</i> were evaluated for their free fatty acids (FFAs) content to test their contribution to truffle allelopathic activity. Linoleic acid was the major FFA detected in all truffle species. In addition to linoleic acid, oleic acid and palmitic acid were the other abundant FFAs in the <i>Tuber</i> spp. extracts. Looking at the total production, <i>T. melanosporum</i> and <i>T. aestivum</i> synthesized significantly higher amounts of all identified FFA than <i>T. magnatum</i> and <i>T. borchii.</i> The allelopathic activity, based on the specific activity (EC<sub>50</sub>) of the identified compounds, was evaluated in the growth of <i>Arabidopsis thaliana</i>, <i>Lotus corniculatus</i>, <i>Melica ciliata</i> and <i>Silene vulgaris</i>. Linoleic acid had the lowest specific activity and palmitic acid had the highest. The black truffle extracts had a higher inhibitory activity than white truffles, and this could be explained by the high relative amount of FFAs in them.
DOI: 10.6084/m9.figshare.1270108
title: Ecological features affect patterns of plant communities in Mediterranean temporary rock pools

description: In this paper, the results of a study on the ecology, floristic composition and spatial assemblages of temporary limestone rock pool plant communities of a central Mediterranean area (S Sicily, the Maltese Islands and Lampedusa) are presented. A total of 76 temporary pools were studied, distributed between the infra-mediterranean and thermo-mediterranean bioclimatic belt. For each temporary rock pools, the floristic composition and cover of the species were determined using standard relevé methods. Moreover, for 50 of these pools, pH, conductivity, soil depth, water-level, altitude and floristic richness and diversity index were assessed. The plant communities were analysed using unweighted pair group method using arithmetic averages and Euclidean distance classification and ordination methods such as canonical correspondence analysis (CCA). A total of four plant communities with specific floristic composition were established, each one with a different dominant species: <i>Callitriche truncata</i>; <i>Elatine gussonei</i>; <i>Tillaea vaillantii</i> and <i>Lythrum hyssopifolia</i>. According to the CCA, the spatial patterns of plant communities follow an ecological gradient related to water level and depth/size of the rock pools: these are the main ecological features affecting the distribution of the plant communities of rock pools. In addition, floristic richness and diversity index showed a slight increase in trend from temporary pools submerged for long periods towards pools submerged for short periods.
DOI: 10.6084/m9.figshare.1270108.v2
title: Ecological features affect patterns of plant communities in Mediterranean temporary rock pools

description: In this paper, the results of a study on the ecology, floristic composition and spatial assemblages of temporary limestone rock pool plant communities of a central Mediterranean area (S Sicily, the Maltese Islands and Lampedusa) are presented. A total of 76 temporary pools were studied, distributed between the infra-mediterranean and thermo-mediterranean bioclimatic belt. For each temporary rock pools, the floristic composition and cover of the species were determined using standard relevé methods. Moreover, for 50 of these pools, pH, conductivity, soil depth, water-level, altitude and floristic richness and diversity index were assessed. The plant communities were analysed using unweighted pair group method using arithmetic averages and Euclidean distance classification and ordination methods such as canonical correspondence analysis (CCA). A total of four plant communities with specific floristic composition were established, each one with a different dominant species: <i>Callitriche truncata</i>; <i>Elatine gussonei</i>; <i>Tillaea vaillantii</i> and <i>Lythrum hyssopifolia</i>. According to the CCA, the spatial patterns of plant communities follow an ecological gradient related to water level and depth/size of the rock pools: these are the main ecological features affecting the distribution of the plant communities of rock pools. In addition, floristic richness and diversity index showed a slight increase in trend from temporary pools submerged for long periods towards pools submerged for short periods.
DOI: 10.6084/m9.figshare.1270108.v1
title: Ecological features affect patterns of plant communities in Mediterranean temporary rock pools

description: In this paper, the results of a study on the ecology, floristic composition and spatial assemblages of temporary limestone rock pool plant communities of a central Mediterranean area (S Sicily, the Maltese Islands and Lampedusa) are presented. A total of 76 temporary pools were studied, distributed between the infra-mediterranean and thermo-mediterranean bioclimatic belt. For each temporary rock pools, the floristic composition and cover of the species were determined using standard relevé methods. Moreover, for 50 of these pools, pH, conductivity, soil depth, water-level, altitude and floristic richness and diversity index were assessed. The plant communities were analysed using unweighted pair group method using arithmetic averages and Euclidean distance classification and ordination methods such as canonical correspondence analysis (CCA). A total of four plant communities with specific floristic composition were established, each one with a different dominant species: <i>Callitriche truncata</i>; <i>Elatine gussonei</i>; <i>Tillaea vaillantii</i> and <i>Lythrum hyssopifolia</i>. According to the CCA, the spatial patterns of plant communities follow an ecological gradient related to water level and depth/size of the rock pools: these are the main ecological features affecting the distribution of the plant communities of rock pools. In addition, floristic richness and diversity index showed a slight increase in trend from temporary pools submerged for long periods towards pools submerged for short periods.