DOI: 10.5281/zenodo.13621947
title: GenCoNet

description: GenCoNet – A Graph Database for the Analysis of Comorbidities by Gene Networks

Alban Shoshi, Ralf Hofestädt, Olga Zolotareva, Marcel Friedrichs, Alex Maier, Vladimir A. Ivanisenko, Victor E. Dosenko, Elena Yu Bragina

The prevalence of comorbid diseases poses a major health issue for millions of people worldwide and an enormous socio-economic burden for society. The molecular mechanisms for the development of comorbidities need to be investigated. For this purpose, a workflow system was developed to aggregate data on biomedical entities from heterogeneous data sources. The process of integrating and merging all data sources of the workflow system was implemented as a semi-automatic pipeline that provides the import, fusion, and analysis of the highly connected biomedical data in a Neo4j database GenCoNet. As a starting point, data on the common comorbid diseases essential hypertension and bronchial asthma was integrated. GenCoNet (https://genconet.kalis-amts.de) is a curated database that provides a better understanding of hereditary bases of comorbidities.

Results

The following results table was extracted from the Neo4j database. It represents all integrated drugs that treat either asthma or essential hypertension and are tagged as approved in DrugBank. Additional drugs contained in the database but not listed here are either not approved or have contraindicates but no treats relationships.




DrugBank ID
Drug Name
Treats
Contraindicates
Induces




DB09273
Doxofylline
Asthma
 
 


DB13139
Levosalbutamol
Asthma
 
 


DB08979
Fenspiride
Asthma
 
 


DB09076
Umeclidinium bromide
Asthma
 
 


DB00043
Omalizumab
Asthma
 
 


DB00180
Flunisolide
Asthma
 
 


DB00221
Isoetarine
Asthma
 
 


DB00332
Ipratropium bromide
Asthma
 
 


DB00394
Beclometasone
Asthma
 
 


DB00443
Betamethasone
Asthma
 
 


DB00471
Montelukast
Asthma
 
 


DB00549
Zafirlukast
Asthma
 
 


DB00651
Dyphylline
Asthma
 
 


DB00716
Nedocromil
Asthma
 
 


DB00744
Zileuton
Asthma
 
 


DB00764
Mometasone
Asthma
 
 


DB00824
Enprofylline
Asthma
 
 


DB00816
Orciprenaline
Asthma
 
 


DB00871
Terbutaline
Asthma
 
 


DB00920
Ketotifen
Asthma
 
 


DB00983
Formoterol
Asthma
 
 


DB00938
Salmeterol
Asthma
 
 


DB01001
Salbutamol
Asthma
 
 


DB00986
Glycopyrronium bromide
Asthma
 
 


DB01025
Amlexanox
Asthma
 
 


DB01003
Cromoglicate
Asthma
 
 


DB01222
Budesonide
Asthma
 
 


DB01064
Isoprenaline
Asthma
 
 


DB01288
Fenoterol
Asthma
 
 


DB01366
Procaterol
Asthma
 
 


DB01407
Clenbuterol
Asthma
 
 


DB01291
Pirbuterol
Asthma
 
 


DB01410
Ciclesonide
Asthma
 
 


DB01411
Pranlukast
Asthma
 
 


DB01408
Bambuterol
Asthma
 
 


DB01409
Tiotropium
Asthma
 
 


DB01656
Roflumilast
Asthma
 
 


DB05039
Indacaterol
Asthma
 
 


DB08906
Fluticasone furoate
Asthma
 
 


DB08957
Hexoprenaline
Asthma
 
 


DB06612
Mepolizumab
Asthma
 
 


DB08897
Aclidinium
Asthma
 
 


DB09082
Vilanterol
Asthma
 
 


DB09080
Olodaterol
Asthma
 
 


DB00277
Theophylline
Asthma
 
Essential Hypertension


DB00588
Fluticasone Propionate
Asthma
 
Essential Hypertension


DB01223
Aminophylline
Asthma
 
Essential Hypertension


DB01303
Oxtriphylline
Asthma
 
Essential Hypertension


DB05266
Ibudilast
Asthma
 
Essential Hypertension


DB00620
Triamcinolone
Asthma
Essential Hypertension
 


DB01363
Ephedra
Asthma
Essential Hypertension
 


DB00668
Epinephrine
Asthma
Essential Hypertension
 


DB00860
Prednisolone
Asthma
Essential Hypertension
 


DB00436
Bendroflumethiazide
Essential Hypertension
 
 


DB00457
Prazosin
Essential Hypertension
 
 


DB00524
Metolazone
Essential Hypertension
 
 


DB00528
Lercanidipine
Essential Hypertension
 
 


DB00325
Nitroprusside
Essential Hypertension
 
 


DB00343
Diltiazem
Essential Hypertension
 
 


DB00381
Amlodipine
Essential Hypertension
 
 


DB00384
Triamterene
Essential Hypertension
 
 


DB00212
Remikiren
Essential Hypertension
 
 


DB00206
Reserpine
Essential Hypertension
 
 


DB00226
Guanadrel
Essential Hypertension
 
 


DB00214
Torasemide
Essential Hypertension
 
 


DB00270
Isradipine
Essential Hypertension
 
 


DB00310
Chlorthalidone
Essential Hypertension
 
 


DB00275
Olmesartan
Essential Hypertension
 
 


DB00177
Valsartan
Essential Hypertension
 
 


DB00187
Esmolol
Essential Hypertension
 
 


DB09236
Lacidipine
Essential Hypertension
 
 


DB09242
Moxonidine
Essential Hypertension
 
 


DB01349
Tasosartan
Essential Hypertension
 
 


DB01275
Hydralazine
Essential Hypertension
 
 


DB08822
Azilsartan medoxomil
Essential Hypertension
 
 


DB00590
Doxazosin
Essential Hypertension
 
 


DB00575
Clonidine
Essential Hypertension
 
 


DB00657
Mecamylamine
Essential Hypertension
 
 


DB09026
Aliskiren
Essential Hypertension
 
 


DB00629
Guanabenz
Essential Hypertension
 
 


DB00880
Chlorothiazide
Essential Hypertension
 
 


DB00678
Losartan
Essential Hypertension
 
 


DB00695
Furosemide
Essential Hypertension
 
 


DB00692
Phentolamine
Essential Hypertension
 
 


DB00966
Telmisartan
Essential Hypertension
 
 


DB00968
Methyldopa
Essential Hypertension
 
 


DB00700
Eplerenone
Essential Hypertension
 
 


DB00742
Mannitol
Essential Hypertension
 
 


DB00796
Candesartan
Essential Hypertension
 
 


DB00808
Indapamide
Essential Hypertension
 
 


DB00876
Eprosartan
Essential Hypertension
 
 


DB01162
Terazosin
Essential Hypertension
 
 


DB01158
Bretylium
Essential Hypertension
 
 


DB01116
Trimethaphan
Essential Hypertension
 
 


DB01170
Guanethidine
Essential Hypertension
 
 


DB01023
Felodipine
Essential Hypertension
 
 


DB01018
Guanfacine
Essential Hypertension
 
 


DB00999
Hydrochlorothiazide
Essential Hypertension
 
 


DB01090
Pentolinium
Essential Hypertension
 
 


DB01089
Deserpidine
Essential Hypertension
 
 


DB01054
Nitrendipine
Essential Hypertension
 
 


DB00492
Fosinopril
Essential Hypertension
 
Asthma


DB00519
Trandolapril
Essential Hypertension
 
Asthma


DB00178
Ramipril
Essential Hypertension
 
Asthma


DB00335
Atenolol
Essential Hypertension
 
Asthma


DB01348
Spirapril
Essential Hypertension
 
Asthma


DB01626
Pargyline
Essential Hypertension
 
Asthma


DB01580
Oxprenolol
Essential Hypertension
 
Asthma


DB01214
Metipranolol
Essential Hypertension
 
Asthma


DB01340
Cilazapril
Essential Hypertension
 
Asthma


DB00264
Metoprolol
Essential Hypertension
 
Asthma


DB09477
Enalaprilat
Essential Hypertension
 
Asthma


DB00622
Nicardipine
Essential Hypertension
 
Asthma


DB00691
Moexipril
Essential Hypertension
 
Asthma


DB00542
Benazepril
Essential Hypertension
 
Asthma


DB00584
Enalapril
Essential Hypertension
 
Asthma


DB00594
Amiloride
Essential Hypertension
 
Asthma


DB00612
Bisoprolol
Essential Hypertension
 
Asthma


DB01197
Captopril
Essential Hypertension
 
Asthma


DB00722
Lisinopril
Essential Hypertension
 
Asthma


DB01193
Acebutolol
Essential Hypertension
 
Asthma


DB01180
Rescinnamine
Essential Hypertension
 
Asthma


DB01029
Irbesartan
Essential Hypertension
 
Asthma


DB00790
Perindopril
Essential Hypertension
 
Asthma


DB04846
Celiprolol
Essential Hypertension
 
Asthma


DB00797
Tolazoline
Essential Hypertension
 
Asthma


DB01115
Nifedipine
Essential Hypertension
 
Asthma


DB04861
Nebivolol
Essential Hypertension
 
Asthma


DB00881
Quinapril
Essential Hypertension
 
Asthma


DB00925
Phenoxybenzamine
Essential Hypertension
 
Asthma


DB00195
Betaxolol
Essential Hypertension
 
Asthma


DB00350
Minoxidil
Essential Hypertension
 
Asthma


DB00661
Verapamil
Essential Hypertension
 
Asthma


DB00421
Spironolactone
Essential Hypertension
 
Asthma


DB00393
Nimodipine
Essential Hypertension
 
Asthma


DB01203
Nadolol
Essential Hypertension
Asthma
Asthma


DB00489
Sotalol
Essential Hypertension
Asthma
Asthma


DB00598
Labetalol
Essential Hypertension
Asthma
Asthma


DB00571
Propranolol
Essential Hypertension
Asthma
Asthma


DB00373
Timolol
Essential Hypertension
Asthma
Asthma


DB01136
Carvedilol
Essential Hypertension
Asthma
Asthma


DB00960
pindolol
Essential Hypertension
Asthma
Asthma