cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.27222558
title: Supplementary Material for: Preliminary efficacy, tolerability, and safety analysis of Darolutamide for metastatic castration‑resistant prostate cancer: a single-center, open-label study

description: Purpose: Darolutamide is a structurally unique second-generation androgen receptor antagonist that has been approved for indications in patients with non-metastatic castration-resistant prostate cancer (nmCRPC) and metastatic hormone-sensitive prostate cancer (mHSPC). The aim is to assess the efficacy and safety of Darolutamide for mCRPC.
Methods: In this single-center, open-label, phase 1 study, patients with previously untreated mCRPC were enrolled and received androgen deprivation therapy (ADT, goserelin acetate 3.6 mg every 28 days) and docetaxel (75 mg per square meter of body surface area every 21 days) with Denosumab (120 mg every 28 days) for bone metastases, Darolutamide (300 mg orally twice daily) in the experimental group, and the control group received the corresponding of placebo. Serum PSA changes were detected and recorded, and imaging changes and adverse events (AEs) were evaluated. The primary endpoints were the safety, tolerability, and antitumor efficacy and the second endpoint was the radiographic progression-free survival (rPFS). 
Results: 37 patients with mCRPC were enrolled. The median time to PSA50 in the Darolutamide group was 1.5 months (95%CI 0.2619- 0.9545), significantly lower than that in the placebo group (3.0 months [95%CI 1.048- 3.818], p= 0.0259); The median time to PSA90 in the experimental group was 4 months (95%CI 0.3094- 1.437), 2 months shorter than that in the placebo group (6.0 months [95%CI 0.6961- 3.232]).With the median follow-up of 6 months, , the median decrease in serum PSA was -81.8% (range -60.4 to -99.9%) in the Darolutamide group and -69.4% (range -50.3 to -89.6%) in the placebo group. Tumor-related pain and AEs were not increased and the median rPFS was not reach.
Conclusions: The combination of Darolutamide and docetaxel was well tolerated with more clinically beneficial than docetaxel alone in previously untreated mCRPC. Darolutamide rapidly reduced PSA levels and prolonged rPFS, and did not increase the incidence of AEs.
DOI: 10.6084/m9.figshare.27677793
title: Supplementary Material for: A comprehensive target panel allows to extend the genetic spectrum of neuroendocrine tumors

description: Introduction. Neuroendocrine tumors (NETs) frequently have a genetic basis, and the range of genes implicated in NETs development continues to expand. Application of targeted gene panels (TGP) in next-generation sequencing (NGS) is a central strategy for elucidating novel variants associated with NETs development. Methods. In this study, we conducted comprehensive molecular-genetic analyses using TGP on a cohort of 93 patients diagnosed with various NETs subtypes, mainly accompanied by various endocrine syndromes: insulinoma (n=26), pheochromocytoma and paraganglioma (PPGL) (n=38), parathyroid adenoma (n=18, including three with insulinoma), and NETs of other locations (n=14). The TGP encompassed genes linked to diverse NETs and other hereditary endocrine disorders, with subsequent variant classification according to the American College of Medical Genetics and Genomics guidelines. Results. Among the identified variants, 20 were found in genes previously linked to specific tumor types, and 10 were found in genes with a limited likelihood and unclear molecular mechanisms of association with observed NETs. Remarkably, 13 variants were discovered in genes not previously associated with the NETs observed in our patients. These genes, such as ABCC8, KCNJ11, KLF11, HABP2, and APC, were implicated in insulinoma; ZNRF3, GNAS, and KCNJ5 were linked with PPGL; parathyroid adenomas were related to variants in SDHB and TP53; while NETs of other locations displayed variants in APC and ABCC8. Conclusion. Our study demonstrates that utilizing broad TGP in examining patients with various functioning NETs, facilitates the identification of new germinal variants in genes that may contribute to the diseases. The verification of revealed findings requires research in vaster sample.
DOI: 10.5281/zenodo.10993424
title: Database of 'Electron Dynamics in Self-Consistent Wave-Particle Interactions with Oblique Chorus Waves'

description: Particle data selected at T=2840 and at T=3050.
DOI: 10.5517/cc1459wh
title: CCDC 1047796: Experimental Crystal Structure Determination

description: Related Article: Sergey V. Loginov, Victor B. Rybakov, Dmitry A. Gordeev, Igor A. Dain, Pavel A. Storozhenko|2015|CSD Communication|||
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.6084/m9.figshare.24161061.v2
title: Rock magnetic dataset, accumulation rates and astrochronology age model for the Trowbarrow section

description: Page 1: rock magnetic datasetPage 2: transformed rock magnetic datasetPage 3: abundance and mineralogy PCA datasetPage 4: sediment accumulation rate modelsPage 5: Astrochronology age modelsPage 6: Horbury allochem data for the sectionPage 7: Microfacies datasetsPage 8 : Separate word file of R-scripts
DOI: 10.5518/1350
title: Gallium ion-binding capacity of mature Pseudomonas aeruginosa biofilm EPS - dataset

description: The CASTEP input and output files for all reported Ga-substitution systems. This includes PolyM and PolyMG alginates, in the 1, 2 and 4 chain forms.
DOI: 10.15468/dl.t73kv8
title: Occurrence Download

description: A dataset containing 3 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Farmeria metzgerioides (Trimen) Willis"
 ]
}

 The dataset includes 3 records from 2 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0014054-241107131044228/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.zztsz4
title: Occurrence Download

description: A dataset containing 451 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Strobilanthes tetrasperma (Champ.) Druce"
 ]
}

 The dataset includes 451 records from 18 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0014055-241107131044228/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.d47anm
title: Occurrence Download

description: A dataset containing 34 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Indotristicha ramosissima (Wight) P.Royen"
 ]
}

 The dataset includes 34 records from 9 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0014057-241107131044228/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.73xeat
title: Occurrence Download

description: A dataset containing 312 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Laodicea undulata (Forbes & Goodsir, 1853)"
 ]
}

 The dataset includes 312 records from 41 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0014058-241107131044228/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.6084/m9.figshare.27282645.v1
title: Supplementary Material for: Analysis of chromosome test results of 24,175 miscarried fetuses in Japan from 2000 to 2021

description: Background : Fetal chromosome abnormalities, the most common cause of spontaneous abortion, were investigated pre-1980s. In recent years, chromosome testing has been outsourced to testing companies in Japan, and there have been few epidemiological studies of chromosome testing of miscarried fetuses on a nationwide scale. 
Methods : We analyzed the chromosome test data of SRL, Inc., one of the largest clinical laboratories that has collected tissue specimens of products of conception derived from miscarried fetuses from hospitals throughout Japan from 2000. 
Results : We collected and analyzed 24,175 cases, among which 8,726 (36.1%) were normal chromosomes, 1,298 (5.4%) were sex chromosome abnormalities, 9,735 (40.3%) were autosomal trisomies, 73 (0.3%) were autosomal monosomies, 840 (3.5%) were ploidy, 512 (2.1%) were chromosome structural abnormalities, and 2,991 (12.4%) were mosaics. The frequency of autosomal trisomy increased at the older maternal ages. By chromosome number, trisomies 22, 16, 21, and 15 were associated with advanced maternal age, but trisomies 13, 14, and 18 were not associated with advanced maternal age. The presence or absence of this maternal age effect was correlated with the chromosome segregation being due to maternal meiosis I or meiosis II. For the sex ratios of the fetuses, we focused on trisomies 22, 21, 18, 16, 15, 14, and 13, and found that only trisomy 16 was significantly more frequently seen in female fetuses. 
Conclusion : The findings of this study provide insights into the basic understanding of miscarriage and will be useful in counseling and medical education.
DOI: 10.6084/m9.figshare.27282645.v2
title: Supplementary Material for: Analysis of chromosome test results of 24,175 miscarried fetuses in Japan from 2000 to 2021

description: Background : Fetal chromosome abnormalities, the most common cause of spontaneous abortion, were investigated pre-1980s. In recent years, chromosome testing has been outsourced to testing companies in Japan, and there have been few epidemiological studies of chromosome testing of miscarried fetuses on a nationwide scale. 
Methods : We analyzed the chromosome test data of SRL, Inc., one of the largest clinical laboratories that has collected tissue specimens of products of conception derived from miscarried fetuses from hospitals throughout Japan from 2000. 
Results : We collected and analyzed 24,175 cases, among which 8,726 (36.1%) were normal chromosomes, 1,298 (5.4%) were sex chromosome abnormalities, 9,735 (40.3%) were autosomal trisomies, 73 (0.3%) were autosomal monosomies, 840 (3.5%) were ploidy, 512 (2.1%) were chromosome structural abnormalities, and 2,991 (12.4%) were mosaics. The frequency of autosomal trisomy increased at the older maternal ages. By chromosome number, trisomies 22, 16, 21, and 15 were associated with advanced maternal age, but trisomies 13, 14, and 18 were not associated with advanced maternal age. The presence or absence of this maternal age effect was correlated with the chromosome segregation being due to maternal meiosis I or meiosis II. For the sex ratios of the fetuses, we focused on trisomies 22, 21, 18, 16, 15, 14, and 13, and found that only trisomy 16 was significantly more frequently seen in female fetuses. 
Conclusion : The findings of this study provide insights into the basic understanding of miscarriage and will be useful in counseling and medical education.
DOI: 10.15468/dl.z3mtmt
title: Occurrence Download

description: A dataset containing 5 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Continent is Asia",
 "TaxonKey is Paphiopedilum tigrinum Koop. & N.Haseg."
 ]
}

 The dataset includes 5 records from 3 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0014060-241107131044228/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.6084/m9.figshare.27282645.v3
title: Supplementary Material for: Analysis of chromosome test results of 24,175 miscarried fetuses in Japan from 2000 to 2021

description: Background : Fetal chromosome abnormalities, the most common cause of spontaneous abortion, were investigated pre-1980s. In recent years, chromosome testing has been outsourced to testing companies in Japan, and there have been few epidemiological studies of chromosome testing of miscarried fetuses on a nationwide scale. 
Methods : We analyzed the chromosome test data of SRL, Inc., one of the largest clinical laboratories that has collected tissue specimens of products of conception derived from miscarried fetuses from hospitals throughout Japan from 2000. 
Results : We collected and analyzed 24,175 cases, among which 8,726 (36.1%) were normal chromosomes, 1,298 (5.4%) were sex chromosome abnormalities, 9,735 (40.3%) were autosomal trisomies, 73 (0.3%) were autosomal monosomies, 840 (3.5%) were ploidy, 512 (2.1%) were chromosome structural abnormalities, and 2,991 (12.4%) were mosaics. The frequency of autosomal trisomy increased at the older maternal ages. By chromosome number, trisomies 22, 16, 21, and 15 were associated with advanced maternal age, but trisomies 13, 14, and 18 were not associated with advanced maternal age. The presence or absence of this maternal age effect was correlated with the chromosome segregation being due to maternal meiosis I or meiosis II. For the sex ratios of the fetuses, we focused on trisomies 22, 21, 18, 16, 15, 14, and 13, and found that only trisomy 16 was significantly more frequently seen in female fetuses. 
Conclusion : The findings of this study provide insights into the basic understanding of miscarriage and will be useful in counseling and medical education.
DOI: 10.6084/m9.figshare.27282645.v4
title: Supplementary Material for: Analysis of chromosome test results of 24,175 miscarried fetuses in Japan from 2000 to 2021

description: Background : Fetal chromosome abnormalities, the most common cause of spontaneous abortion, were investigated pre-1980s. In recent years, chromosome testing has been outsourced to testing companies in Japan, and there have been few epidemiological studies of chromosome testing of miscarried fetuses on a nationwide scale. 
Methods : We analyzed the chromosome test data of SRL, Inc., one of the largest clinical laboratories that has collected tissue specimens of products of conception derived from miscarried fetuses from hospitals throughout Japan from 2000. 
Results : We collected and analyzed 24,175 cases, among which 8,726 (36.1%) were normal chromosomes, 1,298 (5.4%) were sex chromosome abnormalities, 9,735 (40.3%) were autosomal trisomies, 73 (0.3%) were autosomal monosomies, 840 (3.5%) were ploidy, 512 (2.1%) were chromosome structural abnormalities, and 2,991 (12.4%) were mosaics. The frequency of autosomal trisomy increased at the older maternal ages. By chromosome number, trisomies 22, 16, 21, and 15 were associated with advanced maternal age, but trisomies 13, 14, and 18 were not associated with advanced maternal age. The presence or absence of this maternal age effect was correlated with the chromosome segregation being due to maternal meiosis I or meiosis II. For the sex ratios of the fetuses, we focused on trisomies 22, 21, 18, 16, 15, 14, and 13, and found that only trisomy 16 was significantly more frequently seen in female fetuses. 
Conclusion : The findings of this study provide insights into the basic understanding of miscarriage and will be useful in counseling and medical education.
DOI: 10.57745/3kgko3
title: CASSIS_N.zip

description: Surplus azotés départementaux (1920-2020) - résultats du modèle CASSIS-N
DOI: 10.57745/srnsdz
title: readme.txt

description: Dataset description and folder organisation
DOI: 10.15468/dl.73cwdj
title: Occurrence Download

description: A dataset containing 2010 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is China",
 "TaxonKey is Picea likiangensis (Franch.) E.Pritz."
 ]
}

 The dataset includes 2010 records from 41 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0014059-241107131044228/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.27zh4f
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Indotristicha tirunelveliana B.D.Sharma, Karthik. & B.V.Shetty"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0014061-241107131044228/datasets/export for details.
DOI: 10.15468/dl.z7ub8q
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "HasGeospatialIssue is false",
 "HasCoordinate is true",
 "OccurrenceStatus is Present",
 {
 "not" : {
 "BasisOfRecord" : [
 "is one of (Fossil, Living Specimen)"
 ]
 }
 },
 "TaxonKey is one of (Rohdea wangiana H.Z.Feng & Z.Qiang Lu)"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0014062-241107131044228/datasets/export for details.
DOI: 10.15468/dl.mg3dft
title: Occurrence Download

description: A dataset containing 36544 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Vipera aspis (Linnaeus, 1758)"
 ]
}

 The dataset includes 36544 records from 867 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0014053-241107131044228/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.6084/m9.figshare.26598353
title: Additional file 3 of Sex specific molecular networks and key drivers of Alzheimer’s disease

description: Additional file 3: Supplemental Table 3. Jonckheere Trend analysis to identify genes correlated with each clinical trait and APOE genotype in each sex in the PHG of MSBB and the PFC of ROSMAP. Multiple tests were adjusted using the Benjamini–Hochberg’s FDR method. Differences in trend between males and females were assessed as well. A-B) the PHG of MSBB cohort and C-D) the PFC of ROSMAP cohort. E) Intersection among the Jonckheere based DTG signatures in the PHG of the MSBB cohort. F) Intersection of the known AD risk genes and the Jonckheere based DTG signatures in the PHG of the MSBB cohort.
DOI: 10.15468/dl.rr8tjd
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "Geometry" : [
 "POLYGON ((144.962625 -36.84511, 144.962625 -36.847356, 144.960379 -36.847356, 144.960379 -36.851848, 144.985083 -36.851848, 144.985083 -36.847356, 144.971608 -36.847356, 144.971608 -36.84511, 144.962625 -36.84511))"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0066453-240626123714530/datasets/export for details.
DOI: 10.6084/m9.figshare.26567669
title: Additional file 1 of Decoding the underlying mechanisms of Di-Tan-Decoction in treating intracerebral hemorrhage based on network pharmacology

description: Additional file 1: Supplementary Table 1. Protein-Protein Interaction Network.
DOI: 10.6084/m9.figshare.26598476.v1
title: Additional file 1 of The regulatory role and mechanism of lncTUG1 on cartilage apoptosis and inflammation in osteoarthritis

description: Additional file 1.
DOI: 10.6084/m9.figshare.26598476
title: Additional file 1 of The regulatory role and mechanism of lncTUG1 on cartilage apoptosis and inflammation in osteoarthritis

description: Additional file 1.
DOI: 10.6084/m9.figshare.26598362
title: Additional file 6 of Sex specific molecular networks and key drivers of Alzheimer’s disease

description: Additional file 6: Supplemental Table 6. Correlations between clinical and pathological traits and gene modules in the male and female gene co-expression networks in the PHG of the MSBB cohort and the PFC of the ROSMAP cohort. Spearman’s rank correlation was used. Nominal correlation p values and corrected p values by the Benjamini–Hochberg’s method were reported for A) female and B) male gene co-expression network modules in the PHG brain region from the MSBB cohort, as well as C) female and D) male gene co-expression network modules in the PFC brain region from the ROSMAP cohort.
DOI: 10.6084/m9.figshare.26598386
title: Additional file 14 of Sex specific molecular networks and key drivers of Alzheimer’s disease

description: Additional file 14: Supplemental Table 14. Sub-clustering analysis of neurons in mouse scRNA-seq data. A) Number of cells of each neuronal subtype in each sample. B) Proportions of the four neuronal subtypes in each sample. C) Number of differentially expressed genesin each of neuronal subtypes induced by LRP10 OE. In each microglia subtype, differential expression was performed on four comparisons including Female LRP10 OE E4FAD versus Female E4FAD ctrl, Female LRP10 OE E3FAD versus Female E3FAD ctrl, Male LRP10 OE E4FAD versus Male E4FAD ctrl, and Male LRP10 OE E3FAD versus Male E3FAD ctrl.
DOI: 10.24376/rd.sgul.26520106.v1
title: Feasibility study for the development of a sero-correlate of protection against invasive Group B Streptococcus disease (the iGBS study) - iGBS Feasibility

description: <b>Primary objective</b>To establish a control group of GBS colonised women for the main seroepidemiology studyTo test the feasibility of establishing national infant iGBS surveillance through our networks in preparation for the main seroepidemiology study<br><b>Secondary objectives</b>- To establish:the serotype-specific GBS anti-CPS IgG concentrations in cord blood in subjects colonised with GBS at deliverythe rate of serotype-specific GBS anti-CPS IgG concentrations decline during the at risk period of the first three months of lifean opt out approach to cord blood serum collection
DOI: 10.6084/m9.figshare.26598386.v1
title: Additional file 14 of Sex specific molecular networks and key drivers of Alzheimer’s disease

description: Additional file 14: Supplemental Table 14. Sub-clustering analysis of neurons in mouse scRNA-seq data. A) Number of cells of each neuronal subtype in each sample. B) Proportions of the four neuronal subtypes in each sample. C) Number of differentially expressed genesin each of neuronal subtypes induced by LRP10 OE. In each microglia subtype, differential expression was performed on four comparisons including Female LRP10 OE E4FAD versus Female E4FAD ctrl, Female LRP10 OE E3FAD versus Female E3FAD ctrl, Male LRP10 OE E4FAD versus Male E4FAD ctrl, and Male LRP10 OE E3FAD versus Male E3FAD ctrl.
DOI: 10.24376/rd.sgul.26520106
title: Feasibility study for the development of a sero-correlate of protection against invasive Group B Streptococcus disease (the iGBS study) - iGBS Feasibility

description: <b>Primary objective</b>To establish a control group of GBS colonised women for the main seroepidemiology studyTo test the feasibility of establishing national infant iGBS surveillance through our networks in preparation for the main seroepidemiology study<br><b>Secondary objectives</b>- To establish:the serotype-specific GBS anti-CPS IgG concentrations in cord blood in subjects colonised with GBS at deliverythe rate of serotype-specific GBS anti-CPS IgG concentrations decline during the at risk period of the first three months of lifean opt out approach to cord blood serum collection
DOI: 10.6084/m9.figshare.26598359
title: Additional file 5 of Sex specific molecular networks and key drivers of Alzheimer’s disease

description: Additional file 5: Supplemental Table 5. The top ranked modules and their enriched pathways in the male and female gene co-expression networks in the PHG and PFC brain regions. Fold enrichment and Fisher’s Exact Test based enrichment significance were reported. The top ranked 100 modules from A) female and B) male gene co-expression networks in the PHG brain regions, as well as the top ranked 50 modules from C) female and D) male gene co-expression networks in the PFC from the ROSMAP cohort.