cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.4524869.v1
title: Metabolic interactions between cysteamine and epigallocatechin gallate

description: Phase II clinical trials indicate that the combination of cysteamine plus epigallocatechin gallate (EGCG) is effective against cystic fibrosis in patients bearing the most frequent etiological mutation (CFTRΔF508). Here, we investigated the interaction between both agents on cultured respiratory epithelia cells from normal and CFTRΔF508-mutated donors. We observed that the combination of both agents affected metabolic circuits (and in particular the tricarboxylic acid cycle) in a unique way and that cysteamine plus EGCG reduced cytoplasmic protein acetylation more than each of the 2 components alone. In a cell-free system, protein cross-linking activity of EGCG was suppressed by cysteamine. Finally, EGCG was able to enhance the conversion of cysteamine into taurine in metabolic flux experiments. Altogether, these results indicate that multiple pharmacological interactions occur between cysteamine and EGCG, suggesting that they contribute to the unique synergy of both agents in restoring the function of mutated CFTRΔF508.
DOI: 10.6084/m9.figshare.4524812
title: Evaluation of complex toxicity of canbon nanotubes and sodium pentachlorophenol based on earthworm coelomocytes test.xlsx

description: <b>Activities of antioxidant enzymes of the earthworm coelomocytes after exposure to different treatments of MWCNTs (M), PCP-Na (P), including SOD, CAT, ROS,MDA, </b><b>LDH, MMP.</b>
DOI: 10.6084/m9.figshare.4524812.v1
title: Evaluation of complex toxicity of canbon nanotubes and sodium pentachlorophenol based on earthworm coelomocytes test.xlsx

description: <b>Activities of antioxidant enzymes of the earthworm coelomocytes after exposure to different treatments of MWCNTs (M), PCP-Na (P), including SOD, CAT, ROS,MDA, </b><b>LDH, MMP.</b>
DOI: 10.6084/m9.figshare.4524848.v1
title: Metabolic effects of fasting on human and mouse blood in vivo

description: Starvation is a strong physiological stimulus of macroautophagy/autophagy. In this study, we addressed the question as to whether it would be possible to measure autophagy in blood cells after nutrient deprivation. Fasting of mice for 48 h (which causes ∼20% weight loss) or starvation of human volunteers for up to 4 days (which causes &lt;2% weight loss) provokes major changes in the plasma metabolome, yet induces only relatively minor alterations in the intracellular metabolome of circulating leukocytes. White blood cells from mice and human volunteers responded to fasting with a marked reduction in protein lysine acetylation, affecting both nuclear and cytoplasmic compartments. In circulating leukocytes from mice that underwent 48-h fasting, an increase in LC3B lipidation (as assessed by immunoblotting and immunofluorescence) only became detectable if the protease inhibitor leupeptin was injected 2 h before drawing blood. Consistently, measurement of an enhanced autophagic flux was only possible if white blood cells from starved human volunteers were cultured in the presence or absence of leupeptin. Whereas all murine leukocyte subpopulations significantly increased the number of LC3B<sup>+</sup> puncta per cell in response to nutrient deprivation, only neutrophils from starved volunteers showed signs of activated autophagy (as determined by a combination of multi-color immunofluorescence, cytofluorometry and image analysis). Altogether, these results suggest that white blood cells are suitable for monitoring autophagic flux. In addition, we propose that the evaluation of protein acetylation in circulating leukocytes can be adopted as a biochemical marker of organismal energetic status.
DOI: 10.6084/m9.figshare.4524776
title: Data from Why do students quit school? Implications from a dynamical modelling study

description: In 2012, more than three million students dropped out from high school. At this pace, we will have more than 30 million Americans without a high school degree by 2022 and relatively high dropout rates among Hispanic and African American students. We have developed and analysed a data-driven mathematical model that includes multiple interacting mechanisms and estimates of parameters using data from a specifically designed survey applied to a certain group of students of a high school in Chicago to understand dynamics of dropouts. Our analysis suggests students' academic achievement is directly related to the level of parental involvement more than any other factors in our study. However, if the negative peer influence (leading to lower academic grades) increases beyond a critical value, the effect of parental involvement on the dynamics of dropouts becomes negligible.
DOI: 10.6084/m9.figshare.4524848.v3
title: Metabolic effects of fasting on human and mouse blood in vivo

description: Starvation is a strong physiological stimulus of macroautophagy/autophagy. In this study, we addressed the question as to whether it would be possible to measure autophagy in blood cells after nutrient deprivation. Fasting of mice for 48 h (which causes ∼20% weight loss) or starvation of human volunteers for up to 4 d (which causes &lt;2% weight loss) provokes major changes in the plasma metabolome, yet induces only relatively minor alterations in the intracellular metabolome of circulating leukocytes. White blood cells from mice and human volunteers responded to fasting with a marked reduction in protein lysine acetylation, affecting both nuclear and cytoplasmic compartments. In circulating leukocytes from mice that underwent 48-h fasting, an increase in LC3B lipidation (as assessed by immunoblotting and immunofluorescence) only became detectable if the protease inhibitor leupeptin was injected 2 h before drawing blood. Consistently, measurement of an enhanced autophagic flux was only possible if white blood cells from starved human volunteers were cultured in the presence or absence of leupeptin. Whereas all murine leukocyte subpopulations significantly increased the number of LC3B<sup>+</sup> puncta per cell in response to nutrient deprivation, only neutrophils from starved volunteers showed signs of activated autophagy (as determined by a combination of multi-color immunofluorescence, cytofluorometry and image analysis). Altogether, these results suggest that white blood cells are suitable for monitoring autophagic flux. In addition, we propose that the evaluation of protein acetylation in circulating leukocytes can be adopted as a biochemical marker of organismal energetic status.
DOI: 10.6084/m9.figshare.4524767
title: lowest_e1_d-1_HJ_Lagrange_long.mat from Observation-based correction of dynamical models using thermostats

description: Models used in simulation may give accurate short-term trajectories but distort long-term (statistical) properties. In this work, we augment a given approximate model with a control law (a ‘thermostat’) that gently perturbs the dynamical system to target a thermodynamic state consistent with a set of prescribed (possibly evolving) observations. As proof of concept, we provide an example involving a point vortex fluid model on the sphere, for which we show convergence of equilibrium quantities (in the stationary case) and the ability of the thermostat to dynamically track a transient state.
DOI: 10.6084/m9.figshare.4524776.v1
title: Data from Why do students quit school? Implications from a dynamical modelling study

description: In 2012, more than three million students dropped out from high school. At this pace, we will have more than 30 million Americans without a high school degree by 2022 and relatively high dropout rates among Hispanic and African American students. We have developed and analysed a data-driven mathematical model that includes multiple interacting mechanisms and estimates of parameters using data from a specifically designed survey applied to a certain group of students of a high school in Chicago to understand dynamics of dropouts. Our analysis suggests students' academic achievement is directly related to the level of parental involvement more than any other factors in our study. However, if the negative peer influence (leading to lower academic grades) increases beyond a critical value, the effect of parental involvement on the dynamics of dropouts becomes negligible.
DOI: 10.6084/m9.figshare.4524764
title: higher_e1_d-1_HJ_Lagrange_long.mat from Observation-based correction of dynamical models using thermostats

description: Models used in simulation may give accurate short-term trajectories but distort long-term (statistical) properties. In this work, we augment a given approximate model with a control law (a ‘thermostat’) that gently perturbs the dynamical system to target a thermodynamic state consistent with a set of prescribed (possibly evolving) observations. As proof of concept, we provide an example involving a point vortex fluid model on the sphere, for which we show convergence of equilibrium quantities (in the stationary case) and the ability of the thermostat to dynamically track a transient state.
DOI: 10.6084/m9.figshare.4524767.v1
title: lowest_e1_d-1_HJ_Lagrange_long.mat from Observation-based correction of dynamical models using thermostats

description: Models used in simulation may give accurate short-term trajectories but distort long-term (statistical) properties. In this work, we augment a given approximate model with a control law (a ‘thermostat’) that gently perturbs the dynamical system to target a thermodynamic state consistent with a set of prescribed (possibly evolving) observations. As proof of concept, we provide an example involving a point vortex fluid model on the sphere, for which we show convergence of equilibrium quantities (in the stationary case) and the ability of the thermostat to dynamically track a transient state.
DOI: 10.6084/m9.figshare.4524848.v2
title: Metabolic effects of fasting on human and mouse blood <i>in vivo</i>

description: Starvation is a strong physiological stimulus of macroautophagy/autophagy. In this study, we addressed the question as to whether it would be possible to measure autophagy in blood cells after nutrient deprivation. Fasting of mice for 48 h (which causes ∼20% weight loss) or starvation of human volunteers for up to 4 d (which causes &lt;2% weight loss) provokes major changes in the plasma metabolome, yet induces only relatively minor alterations in the intracellular metabolome of circulating leukocytes. White blood cells from mice and human volunteers responded to fasting with a marked reduction in protein lysine acetylation, affecting both nuclear and cytoplasmic compartments. In circulating leukocytes from mice that underwent 48-h fasting, an increase in LC3B lipidation (as assessed by immunoblotting and immunofluorescence) only became detectable if the protease inhibitor leupeptin was injected 2 h before drawing blood. Consistently, measurement of an enhanced autophagic flux was only possible if white blood cells from starved human volunteers were cultured in the presence or absence of leupeptin. Whereas all murine leukocyte subpopulations significantly increased the number of LC3B<sup>+</sup> puncta per cell in response to nutrient deprivation, only neutrophils from starved volunteers showed signs of activated autophagy (as determined by a combination of multi-color immunofluorescence, cytofluorometry and image analysis). Altogether, these results suggest that white blood cells are suitable for monitoring autophagic flux. In addition, we propose that the evaluation of protein acetylation in circulating leukocytes can be adopted as a biochemical marker of organismal energetic status.
DOI: 10.6084/m9.figshare.4524755
title: low_e1_d-1_HJ_Lagrange_long.mat from Observation-based correction of dynamical models using thermostats

description: Models used in simulation may give accurate short-term trajectories but distort long-term (statistical) properties. In this work, we augment a given approximate model with a control law (a ‘thermostat’) that gently perturbs the dynamical system to target a thermodynamic state consistent with a set of prescribed (possibly evolving) observations. As proof of concept, we provide an example involving a point vortex fluid model on the sphere, for which we show convergence of equilibrium quantities (in the stationary case) and the ability of the thermostat to dynamically track a transient state.
DOI: 10.6084/m9.figshare.4524761
title: high_e1_d-1_HJ_Lagrange_long.mat from Observation-based correction of dynamical models using thermostats

description: Models used in simulation may give accurate short-term trajectories but distort long-term (statistical) properties. In this work, we augment a given approximate model with a control law (a ‘thermostat’) that gently perturbs the dynamical system to target a thermodynamic state consistent with a set of prescribed (possibly evolving) observations. As proof of concept, we provide an example involving a point vortex fluid model on the sphere, for which we show convergence of equilibrium quantities (in the stationary case) and the ability of the thermostat to dynamically track a transient state.
DOI: 10.6084/m9.figshare.4524758
title: highest_e1_d-1_HJ_Lagrange_long.mat from Observation-based correction of dynamical models using thermostats

description: Models used in simulation may give accurate short-term trajectories but distort long-term (statistical) properties. In this work, we augment a given approximate model with a control law (a ‘thermostat’) that gently perturbs the dynamical system to target a thermodynamic state consistent with a set of prescribed (possibly evolving) observations. As proof of concept, we provide an example involving a point vortex fluid model on the sphere, for which we show convergence of equilibrium quantities (in the stationary case) and the ability of the thermostat to dynamically track a transient state.
DOI: 10.6084/m9.figshare.4524764.v1
title: higher_e1_d-1_HJ_Lagrange_long.mat from Observation-based correction of dynamical models using thermostats

description: Models used in simulation may give accurate short-term trajectories but distort long-term (statistical) properties. In this work, we augment a given approximate model with a control law (a ‘thermostat’) that gently perturbs the dynamical system to target a thermodynamic state consistent with a set of prescribed (possibly evolving) observations. As proof of concept, we provide an example involving a point vortex fluid model on the sphere, for which we show convergence of equilibrium quantities (in the stationary case) and the ability of the thermostat to dynamically track a transient state.
DOI: 10.6084/m9.figshare.4524755.v1
title: low_e1_d-1_HJ_Lagrange_long.mat from Observation-based correction of dynamical models using thermostats

description: Models used in simulation may give accurate short-term trajectories but distort long-term (statistical) properties. In this work, we augment a given approximate model with a control law (a ‘thermostat’) that gently perturbs the dynamical system to target a thermodynamic state consistent with a set of prescribed (possibly evolving) observations. As proof of concept, we provide an example involving a point vortex fluid model on the sphere, for which we show convergence of equilibrium quantities (in the stationary case) and the ability of the thermostat to dynamically track a transient state.
DOI: 10.6084/m9.figshare.4524758.v1
title: highest_e1_d-1_HJ_Lagrange_long.mat from Observation-based correction of dynamical models using thermostats

description: Models used in simulation may give accurate short-term trajectories but distort long-term (statistical) properties. In this work, we augment a given approximate model with a control law (a ‘thermostat’) that gently perturbs the dynamical system to target a thermodynamic state consistent with a set of prescribed (possibly evolving) observations. As proof of concept, we provide an example involving a point vortex fluid model on the sphere, for which we show convergence of equilibrium quantities (in the stationary case) and the ability of the thermostat to dynamically track a transient state.
DOI: 10.6084/m9.figshare.4524761.v1
title: high_e1_d-1_HJ_Lagrange_long.mat from Observation-based correction of dynamical models using thermostats

description: Models used in simulation may give accurate short-term trajectories but distort long-term (statistical) properties. In this work, we augment a given approximate model with a control law (a ‘thermostat’) that gently perturbs the dynamical system to target a thermodynamic state consistent with a set of prescribed (possibly evolving) observations. As proof of concept, we provide an example involving a point vortex fluid model on the sphere, for which we show convergence of equilibrium quantities (in the stationary case) and the ability of the thermostat to dynamically track a transient state.
DOI: 10.6084/m9.figshare.4524746
title: lower_e1_d-1_HJ_Lagrange_long.mat from Observation-based correction of dynamical models using thermostats

description: Models used in simulation may give accurate short-term trajectories but distort long-term (statistical) properties. In this work, we augment a given approximate model with a control law (a ‘thermostat’) that gently perturbs the dynamical system to target a thermodynamic state consistent with a set of prescribed (possibly evolving) observations. As proof of concept, we provide an example involving a point vortex fluid model on the sphere, for which we show convergence of equilibrium quantities (in the stationary case) and the ability of the thermostat to dynamically track a transient state.
DOI: 10.6084/m9.figshare.4524749
title: Observation-based-correction.zip from Observation-based correction of dynamical models using thermostats

description: Models used in simulation may give accurate short-term trajectories but distort long-term (statistical) properties. In this work, we augment a given approximate model with a control law (a ‘thermostat’) that gently perturbs the dynamical system to target a thermodynamic state consistent with a set of prescribed (possibly evolving) observations. As proof of concept, we provide an example involving a point vortex fluid model on the sphere, for which we show convergence of equilibrium quantities (in the stationary case) and the ability of the thermostat to dynamically track a transient state.
DOI: 10.6084/m9.figshare.4524752
title: neutral_e1_d-1_HJ_Lagrange_long.mat from Observation-based correction of dynamical models using thermostats

description: Models used in simulation may give accurate short-term trajectories but distort long-term (statistical) properties. In this work, we augment a given approximate model with a control law (a ‘thermostat’) that gently perturbs the dynamical system to target a thermodynamic state consistent with a set of prescribed (possibly evolving) observations. As proof of concept, we provide an example involving a point vortex fluid model on the sphere, for which we show convergence of equilibrium quantities (in the stationary case) and the ability of the thermostat to dynamically track a transient state.
DOI: 10.6084/m9.figshare.4524740
title: Weakening Self-Control Biases the Emotional Evaluation of Appetitive Cues

description: Weakening Self-Control Biases the Emotional Evaluation of Appetitive Cues<br><br><br>
DOI: 10.6084/m9.figshare.4524746.v1
title: lower_e1_d-1_HJ_Lagrange_long.mat from Observation-based correction of dynamical models using thermostats

description: Models used in simulation may give accurate short-term trajectories but distort long-term (statistical) properties. In this work, we augment a given approximate model with a control law (a ‘thermostat’) that gently perturbs the dynamical system to target a thermodynamic state consistent with a set of prescribed (possibly evolving) observations. As proof of concept, we provide an example involving a point vortex fluid model on the sphere, for which we show convergence of equilibrium quantities (in the stationary case) and the ability of the thermostat to dynamically track a transient state.
DOI: 10.6084/m9.figshare.4524749.v1
title: Observation-based-correction.zip from Observation-based correction of dynamical models using thermostats

description: Models used in simulation may give accurate short-term trajectories but distort long-term (statistical) properties. In this work, we augment a given approximate model with a control law (a ‘thermostat’) that gently perturbs the dynamical system to target a thermodynamic state consistent with a set of prescribed (possibly evolving) observations. As proof of concept, we provide an example involving a point vortex fluid model on the sphere, for which we show convergence of equilibrium quantities (in the stationary case) and the ability of the thermostat to dynamically track a transient state.
DOI: 10.6084/m9.figshare.4524752.v1
title: neutral_e1_d-1_HJ_Lagrange_long.mat from Observation-based correction of dynamical models using thermostats

description: Models used in simulation may give accurate short-term trajectories but distort long-term (statistical) properties. In this work, we augment a given approximate model with a control law (a ‘thermostat’) that gently perturbs the dynamical system to target a thermodynamic state consistent with a set of prescribed (possibly evolving) observations. As proof of concept, we provide an example involving a point vortex fluid model on the sphere, for which we show convergence of equilibrium quantities (in the stationary case) and the ability of the thermostat to dynamically track a transient state.
DOI: 10.6084/m9.figshare.4524626
title: Table 3: Sample coordinates. The detrital record of Cretaceous to Pliocene sandstones across the NE South American margin

description: Table 3: Sample coordinates
DOI: 10.6084/m9.figshare.4524623
title: Table 1: Qualitative descriptions. The detrital record of Cretaceous to Pliocene sandstones across the NE South American margin

description: Table 1: Qualitative descriptions, all samples.
DOI: 10.6084/m9.figshare.4524626.v1
title: Table 3: Sample coordinates. The detrital record of Cretaceous to Pliocene sandstones across the NE South American margin

description: Table 3: Sample coordinates
DOI: 10.6084/m9.figshare.4524620
title: Table 2: Raw point counts. The detrital record of Cretaceous to Pliocene sandstones across the NE South American margin

description: Table 2: Raw point counts, all samples.
DOI: 10.6084/m9.figshare.4524623.v1
title: Table 1: Qualitative descriptions. The detrital record of Cretaceous to Pliocene sandstones across the NE South American margin

description: Table 1: Qualitative descriptions, all samples.
DOI: 10.6084/m9.figshare.4524617
title: A Survey of the Trajectories Conceptual Framework: Dataset

description: We began by identifying three works—two papers and a book—that constitute the original academic sources of the <i>trajectories framework</i>. We then looked at bibliographical databases to identify works that cited any of these. Starting from over 250 distinct works, we narrowed the list down to 60, selecting only those papers that we considered to be actively engaging with the <i>trajectories framework</i>. We then analyzed the resulting corpus, carefully reading the papers and developing a coding scheme to classify them according to (i) the purpose behind using <i>trajectories</i> and (ii) which particular trajectory concepts they employed.
DOI: 10.6084/m9.figshare.4524620.v1
title: Table 2: Raw point counts. The detrital record of Cretaceous to Pliocene sandstones across the NE South American margin

description: Table 2: Raw point counts, all samples.