cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.7270/q2bz695m
title: BindingDB Entry 9763: PRMT5 inhibitors

description: Small molecule binding data for protein Protein arginine N-methyltransferase 5, Uniprot O14744
DOI: 10.7270/q2bz6962
title: BindingDB Entry 10150: Pyrazolo[3,4-b]pyridine compounds as inhibitors of TAM and MET kinases

description: Small molecule binding data for protein Hepatocyte growth factor receptor, Hepatocyte growth factor receptor [1-13,15-1390], Hepatocyte growth factor receptor [D1228H], Hepatocyte growth factor receptor [D1228N], Hepatocyte growth factor receptor [F1200I], Hepatocyte growth factor receptor [L1195V], Hepatocyte growth factor receptor [Y1230C], Hepatocyte growth factor receptor [Y1230H], Hepatocyte growth factor receptor [Y1230S], Tyrosine-protein kinase Mer, Tyrosine-protein kinase receptor TYRO3, and Tyrosine-protein kinase receptor UFO, Uniprot P08581, P30530, Q06418, and Q12866
DOI: 10.6084/m9.figshare.23660724
title: Supplementary Material for: Feasibility, efficacy and safety of peripheral venous access for chronic double-filtration plasmapheresis with regional citrate anticoagulation

description: Introduction: Peripheral venous access (PVA) is recommended as a first-line vascular approach for therapeutic plasmapheresis with centrifugation methods but not filtration, which usually requires high blood flow. We evaluated the feasibility, efficacy and safety of double-filtration plasmapheresis (DFPP) with PVA, using ultrasound guidance and regional citrate anticoagulation (RCA) i.e. PVA-RCA-DFPP in patients undergoing chronic DFPP. Secondly, we assessed the number of central venous catheters (CVCs) avoided. Methods: A single-center retrospective study evaluated 22 adult patients on chronic DFPP to perform PVA-RCA-DFPP. They were classified into 3 groups: successful (i.e. completion of sessions with PVA), primary failure (i.e. no sessions completed), secondary failure (i.e. ≥ 1 session with PVA completed but secondary return with CVC or arteriovenous fistula (AVF)). Results: Among the 22 patients included (64% men), 7 patients (32%) were classified as primary failures (2 patient refusals, 5 inadequate PVAs), 1 patient (5%) as a secondary failure (due to uncomfortable venipunctures), and 14 patients (64%) as successful. In the successful group including 12 patients treated for Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) and 2 patients for Familial Hypercholesterolemia (FH) (2 patients), 116 sessions were performed, with a median treated plasma volume of 4.3L [IQR 3.6-4.6] (45 ml/kg) for a median duration of 134 minutes [IQR 122-144], and a median blood flow of 94 ml/min IQR [87-103]. For the CIDP group, 90 % of sessions achieved a plasma volume &gt; 1 TPV and for the FH group 91% of sessions achieved an LDLc reduction &gt; 60%. Eleven sessions out of 116 (9%) were interrupted, mostly due to PVA dysfunction (5/11) and circuit clotting (4/11). Session interruptions decreased significantly between each patient’s first and following sessions (29% to 7%, p=0.009). Conclusion: Chronic PVA-RCA-DFPP can be performed safely and efficiently, avoiding the use of CVCs.
DOI: 10.6084/m9.figshare.23830116
title: Yalong River-Detrital AFT Data (Yaling Tao).xlsx

description: This dataset belongs to the manuscript entitled "<b>Long-term stability of the low-relief landscape in southeastern Tibet revealed by detrital fission track thermochronometry</b>" by Tao Yaling
DOI: 10.6084/m9.figshare.23830116.v1
title: Yalong River-Detrital AFT Data (Yaling Tao).xlsx

description: This dataset belongs to the manuscript entitled "<b>Long-term stability of the low-relief landscape in southeastern Tibet revealed by detrital fission track thermochronometry</b>" by Tao Yaling
DOI: 10.57967/hf/0959
title: Drone-based-Agricultural-Dataset-for-Crop-Yield-Estimation
DOI: 10.5285/621cf434-1517-4b36-887d-4285315af695
title: Reconstructed temperature and tephra deposit age data from Yanou Lake, Fildes Peninsula, South Shetland Islands, northern Antarctic Peninsula

description: The dataset comprises reconstructed temperature and tephra deposits age data from Yanou Lake, Fildes Peninsula, King George Island, South Shetland Islands. Data are calibrated to the 2020 radiocarbon calibration curves. The Antarctic and global glycerol dialkyl glycerol tetraether (GDGT) lipid biomarker temperature calibration are included. GDGT MSAT (mean summer air temperature) data was obtained by recalibrating the Pearson et al. (2011) global and Foster et al. (2016) Antarctic lake surface GDGT MSAT datasets. This dataset includes updates with new calibration of data originally published in Roberts et al. (2017). These revisions were funded as part of the IMCONet (FP7 IRSES, action no. 318718) program led by Doris Abele (AWI); the Natural Environment Research Council (NERC/BAS-CGS Grant no.81); the NERC/BAS science programmes CACHE-PEP: Natural climate variability - extending the Americas palaeoclimate transect through the Antarctic Peninsula to the pole and GRADES-QWAD: Quaternary West Antarctic Deglaciations.
description: Glycerol dialkyl glycerol tetraether (GDGT) analysis of freshwater-brackish sediments from Yanou Lake dating to c. 6 ka was used to reconstruct mean summer air temperature (MSAT) and MSAT anomaly profiles (relative to the pre-industrial mean 1-0.25 cal. ka BP; RMSE = 2.45 degrees C; Pearson et al., 2011; Foster et al., 2016; Roberts et al., 2017). The published GDGT palaeotemperature reconstructions for Yanou Lake in Roberts et al. (2017) overestimated MSAT for data older than 2000 years due to a lack of data at the upper end of the Foster et al. (2016) Antarctic calibration dataset. Therefore, we constructed a new MSAT anomaly profile by combining GDGT-MSAT data from the global (Pearson et al., 2011) and Antarctic (Foster et al., 2016) GDGT calibration datasets and applied a new regression model based on the same compounds used in both (Juggins pers. comm). This produced a revised mean MSAT anomaly of 0.06 +/- 1.50 degrees C for the last 6,000 years of the Yanou Lake record, which is of a similar magnitude to the James Ross Island ice core mean annual temperature anomaly of 0.01 plus/minus 0.35 degrees C in the same period. Revised modelled ages for tephra deposits in the Yanou Lake record were produced using 2020 calibration curves and Bayesian age-depth modelling in BACON v. 2.5 in R (Blaauw and Christen, 2011).
description: RMSE = 2.45±1.44 °C and 1.74±1.44 °C for global calibration temperature reconstructions and Antarctic/revised global+Antarctic calibration temperature reconstructions
DOI: 10.5285/85c30cc3-6ce6-4a3d-be60-0bddbe69e5bb
title: Proxy data from the Emerald Lake sediment record on Macquarie Island.

description: The dataset comprises of proxy data from the Emerald Lake sediment record dating back to 12.1ka BP were extracted on Macquarie Island. Three independent methods to reconstruct past changes in Southern Hemisphere Westerly wind (SHW) intensity. Core scanning (ITRAX XRF) and multispectral data (SPECIM) originally published in Saunders et al. (2018) have been updated to the 2020 radiocarbon calibration curve. This research was funded by NERC Standard grant NE/K004514/1 (D.A.H., S.J.R., L.S.), Swiss National Science Foundation Ambizione Postdoctoral Research Fellowship PZ00P2_136835/1 (K.M.S.), Swiss National Science Foundation Grant 200021_172586 (M.G.) and Australian Antarctic Science grants 3117 and 4156 (K.M.S.). K.M.S. was also supported by PhD funding as part of grant 2663 to A. McMinn, an Australian Postgraduate Award (2004-2008) and an Australian Institute of Nuclear Science and Engineering Postgraduate Research Award.
description: A series of lake sediment cores dating back to c. 12.1 ka BP were extracted from Emerald Lake on the west coast of sub-Antarctic Macquarie Island. We applied three independent methods to reconstruct past changes in SHW intensity. 1) To reconstruct past sea salt aerosol inputs, we developed a method to track past changes in lake water conductivity (a function of sea salt aerosol input) using diatom-based inference models. 2) ITRAX XRF core scanning (XRFCS) analysis was used to track inputs of minerogenic aerosols into the lake, focusing on Ti as the most widely used indicator of allochthonous inputs 3) Cores were scanned using a Specim hyperspectral camera, which measures reflected optical properties between wavelengths from 400-1000 nm. The ratio of reflectance between 850 and 900 nm (R850/R900) was used as an additional indicator of minerogenic inputs We have updated the age depth model in Saunders et al. (2018) and applied this update to these datasets. Recalibration and age depth models have been updated to 2020 calibration curves (Sh20) in the R package BACON v. 2.5 for Bayesian age-depth modelling (Blaauw and Christen, 2011).
description: Age data includes minimum and maximum 95% confidence interval ranges.
DOI: 10.20387/bonares-ymyx-rq93
title: Chlorophyll-Data of eutrophied urban ponds in Lübeck (Germany, Schleswig-Holstein)

description: The dataset contains weekly total chlorophyll data as well as cyano-chlorophyll data gathered in 2022 in eutrophic urban ponds (Krähenteich, Mühlenteich). The ponds are fed by the river Wakenitz in Lübeck (Schleswig-Holstein - Germany). The measuring period spans the timeframe needed for chlorophyll-based assessment of trophic statet according to LAWA (May to October). As measuring-device a fluorometer (bbe AlgaeTorch 10) was used.

Research domain: Other

Research question: None
DOI: 10.5281/zenodo.8211452
title: APObind core set for KarmaDock (229 protein-ligand complexes).

description: APObind core set for KarmaDock (229 protein-ligand complexes).
DOI: 10.5281/zenodo.8211451
title: APObind core set for KarmaDock (229 protein-ligand complexes).

description: APObind core set for KarmaDock (229 protein-ligand complexes).
DOI: 10.6084/m9.figshare.21501135
title: A qualitative evaluation of the revised amyotrophic lateral sclerosis functional rating scale (ALSFRS-R) by the patient community: a web-based cross-sectional survey

description: The revised Amyotrophic Lateral Sclerosis Functional Rating Scale (ALSFRS-R) is the most commonly used outcome measure in ALS studies. The aim of this study was to identify potential limitations of the ALSFRS-R from the perspective of people living with ALS and their caregivers. A web-based survey was developed by investigators, people living with ALS, and their caregivers, and shared across social media. For each item, participants were asked, “Can you think of a situation where you might not be able to answer this item accurately or that your answer might not reflect your abilities?” Responses were divided into two categories: criticisms that could be addressed in a manual or issues with the items/responses that would require measure modification. 57 participants (72% participants with ALS, 28% caregivers) responded to at least one item question, of which 71.9% expressed concern about at least one item. The most frequently identified items were speech, walking, and cutting food. Common criticisms were: language used is of a medical literacy level too high; item is situational; difficult to distinguish the difference between response choices; and the structure and/or underlying assumptions of the item makes it difficult to answer. Several items of the ALSFRS-R were considered to inaccurately reflect the abilities of patients with ALS. The ALSFRS-R may need a revision to address these issues, preferably in co-development with people living with ALS and their caregivers, and/or alternate outcome measures should be considered for patients with ALS.
DOI: 10.6084/m9.figshare.21400268
title: Reliable change indices for the Italian Edinburgh Cognitive and Behavioral ALS Screen (ECAS)

description: This study aimed at providing standardized regression-based (SRB) reliable change indices (RCIs) for the Italian Edinburgh Cognitive and Behavioral ALS Screen (ECAS). Thirty-one consecutive ALS patients undergoing the ECAS were followed-up (T1) at 6.5 ± 1 months (<i>range</i> = 5–8). Ceiling/floor effects, practice effect, and test–retest reliability were assessed. Each ECAS measure was regressed by stepwise-entering as predictors demographics, respective T0 scores, T0 disease duration and ALSFRS-R, retest interval, and progression rate (ΔFS) – i.e., (48 - ALSFRS-R<sub>T0</sub>)/disease duration<sub>T0</sub> in months. Ceiling effects were infrequently detected, no practice effect emerged and all ECAS measures were reliable at retest (except for Language and Visuo-spatial subscales). T0 scores predicted all ECAS measures except for the Visuo-spatial subscale. The availability of RCIs for the Italian ECAS will aid ALS-related clinical practice and research within the longitudinal dimension.
DOI: 10.6084/m9.figshare.21400268.v1
title: Reliable change indices for the Italian Edinburgh Cognitive and Behavioral ALS Screen (ECAS)

description: This study aimed at providing standardized regression-based (SRB) reliable change indices (RCIs) for the Italian Edinburgh Cognitive and Behavioral ALS Screen (ECAS). Thirty-one consecutive ALS patients undergoing the ECAS were followed-up (T1) at 6.5 ± 1 months (<i>range</i> = 5–8). Ceiling/floor effects, practice effect, and test–retest reliability were assessed. Each ECAS measure was regressed by stepwise-entering as predictors demographics, respective T0 scores, T0 disease duration and ALSFRS-R, retest interval, and progression rate (ΔFS) – i.e., (48 - ALSFRS-R<sub>T0</sub>)/disease duration<sub>T0</sub> in months. Ceiling effects were infrequently detected, no practice effect emerged and all ECAS measures were reliable at retest (except for Language and Visuo-spatial subscales). T0 scores predicted all ECAS measures except for the Visuo-spatial subscale. The availability of RCIs for the Italian ECAS will aid ALS-related clinical practice and research within the longitudinal dimension.
DOI: 10.6084/m9.figshare.21501135.v1
title: A qualitative evaluation of the revised amyotrophic lateral sclerosis functional rating scale (ALSFRS-R) by the patient community: a web-based cross-sectional survey

description: The revised Amyotrophic Lateral Sclerosis Functional Rating Scale (ALSFRS-R) is the most commonly used outcome measure in ALS studies. The aim of this study was to identify potential limitations of the ALSFRS-R from the perspective of people living with ALS and their caregivers. A web-based survey was developed by investigators, people living with ALS, and their caregivers, and shared across social media. For each item, participants were asked, “Can you think of a situation where you might not be able to answer this item accurately or that your answer might not reflect your abilities?” Responses were divided into two categories: criticisms that could be addressed in a manual or issues with the items/responses that would require measure modification. 57 participants (72% participants with ALS, 28% caregivers) responded to at least one item question, of which 71.9% expressed concern about at least one item. The most frequently identified items were speech, walking, and cutting food. Common criticisms were: language used is of a medical literacy level too high; item is situational; difficult to distinguish the difference between response choices; and the structure and/or underlying assumptions of the item makes it difficult to answer. Several items of the ALSFRS-R were considered to inaccurately reflect the abilities of patients with ALS. The ALSFRS-R may need a revision to address these issues, preferably in co-development with people living with ALS and their caregivers, and/or alternate outcome measures should be considered for patients with ALS.
DOI: 10.6084/m9.figshare.20411363
title: Remote digital assessment of amyotrophic lateral sclerosis functional rating scale – a multicenter observational study

description: Remote self-assessment of the revised amyotrophic lateral sclerosis functional rating scale (ALSFRS-R) using digital data capture was investigated for its feasibility as an add-on to ALSFRS-R assessments during multidisciplinary clinic visits. From August 2017 to December 2021, at 12 ALS centers in Germany, an observational study on remote assessment of the ALSFRS-R was performed. In addition to the assessment of ALSFRS-R during clinic visits, patients were offered a digital self-assessment of the ALSFRS-R – either on a computer or on a mobile application (“ALS-App”). An estimated multicenter cohort of 4,670 ALS patients received care at participating ALS centers. Of these patients, 971 remotely submitted the ALSFRS-R, representing 21% of the multicenter cohort. Of those who opted for remote assessment, 53.7% (<i>n</i> = 521) completed a minimum of 4 ALSFRS-R per year with a mean number of 10.9 assessments per year. Different assessment frequencies were found for patients using a computer (7.9 per year, <i>n</i> = 857) and mobile app (14.6 per year, <i>n</i> = 234). Patients doing remote assessments were more likely to be male and less functionally impaired but many patients with severe disability managed to complete it themselves or with a caregiver (35% of remote ALSFRS-R cohort in King’s Stage 4). In a dedicated ALS center setting remote digital self-assessment of ALSFRS-R can provide substantial data which is complementary and potentially an alternative to clinic assessments and could be used for research purposes and person-level patient management. Addressing barriers relating to patient uptake and adherence are key to its success.
DOI: 10.6084/m9.figshare.20411363.v1
title: Remote digital assessment of amyotrophic lateral sclerosis functional rating scale – a multicenter observational study

description: Remote self-assessment of the revised amyotrophic lateral sclerosis functional rating scale (ALSFRS-R) using digital data capture was investigated for its feasibility as an add-on to ALSFRS-R assessments during multidisciplinary clinic visits. From August 2017 to December 2021, at 12 ALS centers in Germany, an observational study on remote assessment of the ALSFRS-R was performed. In addition to the assessment of ALSFRS-R during clinic visits, patients were offered a digital self-assessment of the ALSFRS-R – either on a computer or on a mobile application (“ALS-App”). An estimated multicenter cohort of 4,670 ALS patients received care at participating ALS centers. Of these patients, 971 remotely submitted the ALSFRS-R, representing 21% of the multicenter cohort. Of those who opted for remote assessment, 53.7% (<i>n</i> = 521) completed a minimum of 4 ALSFRS-R per year with a mean number of 10.9 assessments per year. Different assessment frequencies were found for patients using a computer (7.9 per year, <i>n</i> = 857) and mobile app (14.6 per year, <i>n</i> = 234). Patients doing remote assessments were more likely to be male and less functionally impaired but many patients with severe disability managed to complete it themselves or with a caregiver (35% of remote ALSFRS-R cohort in King’s Stage 4). In a dedicated ALS center setting remote digital self-assessment of ALSFRS-R can provide substantial data which is complementary and potentially an alternative to clinic assessments and could be used for research purposes and person-level patient management. Addressing barriers relating to patient uptake and adherence are key to its success.
DOI: 10.5281/zenodo.7538266
title: Extreme precipitation records in Antarctica [Dataset]

description: This is the dataset associated to the research 'Extreme precipitation records in Antarctica' published in <em>International Journal of Climatology</em>. This repository contains: Precipitation extremes for each <em>model</em> at every grid point for a duration of <em>xxx</em> days. Files named: [<em>model</em>]_PCP_max_[<em>xxx</em>]d.csv Dimensions for ERA5: [lons, lats] Dimensions for RACMO2: [grid_x, grid_y] Units: mm Dimensions to plot the precipitation extremes: lons (longitudes), lats (latitudes) and duration. Files named: [<em>model</em>]_PCP_max_lats.csv Dimensions for ERA5: [lats] Dimensions for RACMO2: [grid_x, grid_y] Units: degrees [<em>model</em>]_PCP_max_lons.csv Dimensions for ERA5: [lons] Dimensions for RACMO2: [grid_x, grid_y] Units: degrees [<em>model</em>]_PCP_max_duration.csv Dimensions: [time] Units: days World Precipitation Records from 1 day. File named: Max_WR_from1day.csv (first row duration [days]; second row precipitation [mm]) <strong>How to cite</strong> If you use this dataset, please cite the accompanying paper as: González-Herrero, S.,Vasallo, F., Bech, J., Gorodetskaya, I., Elvira, B., & Justel, A. (2023). Extreme precipitation records in Antarctica.International Journal of Climatology, 43(7), 3125–3138. https://doi.org/10.1002/joc.8020 <strong>Complementary code</strong> You can find the jupyter notebooks to complement the research in: https://doi.org/10.1002/joc.8020 <strong>Contact</strong> If you have any question, please contact with Sergi at sergi.gonzalez@slf.ch
description: {"references": ["Gonz\u00e1lez-Herrero, S.,Vasallo, F., Bech, J., Gorodetskaya, I., Elvira, B., & Justel, A. (2023). Extreme precipitation records in Antarctica.International Journal of Climatology, 43(7), 3125\u20133138.\u00a0https://doi.org/10.1002/joc.8020"]}
DOI: 10.5281/zenodo.7538265
title: Extreme precipitation records in Antarctica [Dataset]

description: This is the dataset associated to the research 'Extreme precipitation records in Antarctica' published in <em>International Journal of Climatology</em>. This repository contains: Precipitation extremes for each <em>model</em> at every grid point for a duration of <em>xxx</em> days. Files named: [<em>model</em>]_PCP_max_[<em>xxx</em>]d.csv Dimensions for ERA5: [lons, lats] Dimensions for RACMO2: [grid_x, grid_y] Units: mm Dimensions to plot the precipitation extremes: lons (longitudes), lats (latitudes) and duration. Files named: [<em>model</em>]_PCP_max_lats.csv Dimensions for ERA5: [lats] Dimensions for RACMO2: [grid_x, grid_y] Units: degrees [<em>model</em>]_PCP_max_lons.csv Dimensions for ERA5: [lons] Dimensions for RACMO2: [grid_x, grid_y] Units: degrees [<em>model</em>]_PCP_max_duration.csv Dimensions: [time] Units: days World Precipitation Records from 1 day. File named: Max_WR_from1day.csv (first row duration [days]; second row precipitation [mm]) <strong>How to cite</strong> If you use this dataset, please cite the accompanying paper as: González-Herrero, S.,Vasallo, F., Bech, J., Gorodetskaya, I., Elvira, B., & Justel, A. (2023). Extreme precipitation records in Antarctica.International Journal of Climatology, 43(7), 3125–3138. https://doi.org/10.1002/joc.8020 <strong>Complementary code</strong> You can find the jupyter notebooks to complement the research in: https://doi.org/10.1002/joc.8020 <strong>Contact</strong> If you have any question, please contact with Sergi at sergi.gonzalez@slf.ch
description: {"references": ["Gonz\u00e1lez-Herrero, S.,Vasallo, F., Bech, J., Gorodetskaya, I., Elvira, B., & Justel, A. (2023). Extreme precipitation records in Antarctica.International Journal of Climatology, 43(7), 3125\u20133138.\u00a0https://doi.org/10.1002/joc.8020"]}
DOI: 10.5281/zenodo.8211468
title: Evaluation and optimisation of the soil carbon turnover routine in the MONICA model (version 3.3.1) - Data

description: Zip file consisting of the data used in the manuscript "Evaluation and optimisation of the soil carbon turnover routine in the MONICA model".
DOI: 10.5281/zenodo.8211467
title: Evaluation and optimisation of the soil carbon turnover routine in the MONICA model (version 3.3.1) - Data

description: Zip file consisting of the data used in the manuscript "Evaluation and optimisation of the soil carbon turnover routine in the MONICA model".