cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.21161953
title: Empathy in medical students: analysis as a function of the undergraduate period and sociodemographic profile

description: Abstract: Introduction: Empathy, considered one of the most remarkable characteristics of great medical professionals, is the central element of the doctor-patient relationship and of person-centered care. Objective: To investigate how levels of empathy are manifested in medical students throughout their undergraduate course. Method: This is a quantitative, analytical, observational and cross-sectional study, carried out in a private higher education institution, located in the northeast of Brazil. The research was carried out by applying the Jefferson Scale of Empathy-Student version (JSE-S) and the correlation of the data obtained in the scale with the undergraduate school period and sociodemographic profile of the students, aiming to verify which correlations were significant for the expression of students’ empathy levels, as well as whether there is an erosion during training. Data collection took place between the months of October and November 2020. The study assessed 193 participants, including students attending the first year, an intermediate year and last year of the medical course. The sampling method used was by accessibility and convenience. Results: The global average score of the level of empathy in the group of all study participants (n = 193) was 123.56 ± 11.73. Whereas, by period, it was 124.78 ± 9.85 for first-year students, 124.00 ± 11.87 for intermediate-year students and 120.63 ± 13.57 for last-year students. There was no statistical difference between global scores or by psychometric factor when comparing the three studied groups. As for the correlation of JSE-S with the sociodemographic profile, the variables female gender and reason for choosing the course due to vocation were predictors of higher empathy scores. Conclusion: There was no evidence of empathy erosion regarding the levels of empathy among medical students throughout their undergraduate course, and female students and those who chose the course because they felt they had a vocation for Medicine showed significantly higher levels of empathy. More studies on this topic are essential, considering the importance of a balanced technical-scientific-humanistic posture to enable a medical practice of excellence.
DOI: 10.6084/m9.figshare.21161953.v1
title: Empathy in medical students: analysis as a function of the undergraduate period and sociodemographic profile

description: Abstract: Introduction: Empathy, considered one of the most remarkable characteristics of great medical professionals, is the central element of the doctor-patient relationship and of person-centered care. Objective: To investigate how levels of empathy are manifested in medical students throughout their undergraduate course. Method: This is a quantitative, analytical, observational and cross-sectional study, carried out in a private higher education institution, located in the northeast of Brazil. The research was carried out by applying the Jefferson Scale of Empathy-Student version (JSE-S) and the correlation of the data obtained in the scale with the undergraduate school period and sociodemographic profile of the students, aiming to verify which correlations were significant for the expression of students’ empathy levels, as well as whether there is an erosion during training. Data collection took place between the months of October and November 2020. The study assessed 193 participants, including students attending the first year, an intermediate year and last year of the medical course. The sampling method used was by accessibility and convenience. Results: The global average score of the level of empathy in the group of all study participants (n = 193) was 123.56 ± 11.73. Whereas, by period, it was 124.78 ± 9.85 for first-year students, 124.00 ± 11.87 for intermediate-year students and 120.63 ± 13.57 for last-year students. There was no statistical difference between global scores or by psychometric factor when comparing the three studied groups. As for the correlation of JSE-S with the sociodemographic profile, the variables female gender and reason for choosing the course due to vocation were predictors of higher empathy scores. Conclusion: There was no evidence of empathy erosion regarding the levels of empathy among medical students throughout their undergraduate course, and female students and those who chose the course because they felt they had a vocation for Medicine showed significantly higher levels of empathy. More studies on this topic are essential, considering the importance of a balanced technical-scientific-humanistic posture to enable a medical practice of excellence.
DOI: 10.6084/m9.figshare.21161959
title: Selective Cytotoxic effect of Probiotic, Paraprobiotic and Postbiotics of L.casei strains against Colorectal Cancer Cells: Invitro studies

description: Abstract This study highlights the cytotoxic effect of three L. casei strains on colorectal cell lines in invitro conditions. Different concentrations of live, heat killed (HK) and cell free supernatant (CFS) of three L.casei strains were subjected to CaCo2 and MRC5 cell lines. The viability of the treated and untreated cells was determined after 72 hrs by MTT assay, and IC50 estimated. Apoptosis was evaluated by Annexin V-propidium iodide method using flow cytometry. The live, HK and CFS of the L. casei strains showed cytotoxic effects on colorectal cell lines with significant differences. The cytotoxicity effects of live cells on CaCo2 cells were significantly higher (p˂0.01) than the HK cells. A dose dependent response was observed, as higher concentrations resulted in enhanced cytotoxicity effects. Live L.casei 1296-2cells inhibited 91% of CaCo2 cell growth, with IC50 of less than 108 cfu/ml. MRS medium and concentrations of CFS at above 20% v/v, were cytotoxic to the normal cell lines. Flow cytometry analyses of L. casei 1296-2 indicated that cytotoxicity effects on CaCo2 cells is related to apoptotic induction. Invitro studies indicate that Live and CFS of L. casei 1296-2 might be promising candidate for the control of colorectal cancers.
DOI: 10.6084/m9.figshare.21161959.v1
title: Selective Cytotoxic effect of Probiotic, Paraprobiotic and Postbiotics of L.casei strains against Colorectal Cancer Cells: Invitro studies

description: Abstract This study highlights the cytotoxic effect of three L. casei strains on colorectal cell lines in invitro conditions. Different concentrations of live, heat killed (HK) and cell free supernatant (CFS) of three L.casei strains were subjected to CaCo2 and MRC5 cell lines. The viability of the treated and untreated cells was determined after 72 hrs by MTT assay, and IC50 estimated. Apoptosis was evaluated by Annexin V-propidium iodide method using flow cytometry. The live, HK and CFS of the L. casei strains showed cytotoxic effects on colorectal cell lines with significant differences. The cytotoxicity effects of live cells on CaCo2 cells were significantly higher (p˂0.01) than the HK cells. A dose dependent response was observed, as higher concentrations resulted in enhanced cytotoxicity effects. Live L.casei 1296-2cells inhibited 91% of CaCo2 cell growth, with IC50 of less than 108 cfu/ml. MRS medium and concentrations of CFS at above 20% v/v, were cytotoxic to the normal cell lines. Flow cytometry analyses of L. casei 1296-2 indicated that cytotoxicity effects on CaCo2 cells is related to apoptotic induction. Invitro studies indicate that Live and CFS of L. casei 1296-2 might be promising candidate for the control of colorectal cancers.
DOI: 10.6084/m9.figshare.21161961
title: Characterization of a complex carbonate-silicate apatite ore and its concentration by a two-stage anionic flotation method

description: Abstract A carbonate-silicate low weathering phosphate ore from an igneous origin deposit in Southeastern Brazil presents a challenge mainly for apatite flotation from its gangue minerals, calcite and dolomite, plus the presence of phlogopite, diopside, magnetite, richterite, ilmenite, vermiculite, quartz and many other minor impurities. Recently, selectivity has been greatly enhanced by using CO2 instead of air, so in this study a variant process was used. In a first stage, carbonate minerals were floated with the use of CO2 as bubble gas; the collector was a saponified fatty acid, medium hydrocarbon chain. Then, the depressed minerals were floated using a sulfosuccinate collector and air as the froth gas. A significant improvement in the apatite concentration has been achieved: the initial 5.28% P2O5 tenor was raised to 21.58%. The overall P2O5 recovery was 61.8% and 12.0% of the global mass recovery. However, the amount of impurities was still significant with the presence of carbonates, phlogopite and minor magnetite. Therefore, the processing route presented herein is quite viable, but further research is necessary to improve the whole method.
DOI: 10.6084/m9.figshare.21161961.v1
title: Characterization of a complex carbonate-silicate apatite ore and its concentration by a two-stage anionic flotation method

description: Abstract A carbonate-silicate low weathering phosphate ore from an igneous origin deposit in Southeastern Brazil presents a challenge mainly for apatite flotation from its gangue minerals, calcite and dolomite, plus the presence of phlogopite, diopside, magnetite, richterite, ilmenite, vermiculite, quartz and many other minor impurities. Recently, selectivity has been greatly enhanced by using CO2 instead of air, so in this study a variant process was used. In a first stage, carbonate minerals were floated with the use of CO2 as bubble gas; the collector was a saponified fatty acid, medium hydrocarbon chain. Then, the depressed minerals were floated using a sulfosuccinate collector and air as the froth gas. A significant improvement in the apatite concentration has been achieved: the initial 5.28% P2O5 tenor was raised to 21.58%. The overall P2O5 recovery was 61.8% and 12.0% of the global mass recovery. However, the amount of impurities was still significant with the presence of carbonates, phlogopite and minor magnetite. Therefore, the processing route presented herein is quite viable, but further research is necessary to improve the whole method.
DOI: 10.6084/m9.figshare.21137375
title: Production and essential oil quality of Varroniacurassavica DC.submitted to different spacing between plants, harvest season and drying temperatures of leaves

description: ABSTRACT: Varroniacurassavica is a Brazilian native medicinal species. Among the critical points influencing the phytochemical quality of bioactive compounds is the spacing between plants, harvest and post-harvest. This research aimed evaluated the influence of plant distance, harvest season, and leaves drying temperature on the yield and phytochemical quality of V. curassavica essential oil. The organic cultivation was carried out in 2018/2019 using 0.6 x 1.0; 0.8 x 1.0; 1.0 x 1.0; 1.0 x 1.6 m spacing between plants. The macro and micronutrient contents of the leaves were evaluated and no considerable changes were observed. In 2018 the harvest was performed in summer, autumn, and winter, and the harvested leaves were immediately submitted to the drying process at 40 °C. In 2019 the harvest was performed in winter, and the leaves were submitted to the drying process at 40, 50, and 60 °C. The essential oil was extracted by hydrodistillation and the chemical constituents were evaluated using CG-MS. The essential oil yield was significantly higher in winter and used 0.8 x 1.0 m and 1.0 x 1.0 m spacing between plants. The alpha-humulene content remained within the recommended standards at all analyzed temperatures. Although, the drying temperatures tested did not compromise the alpha-humulene content, the increasing temperature caused a reduction in the essential oil yield. Thus, it is recommended for the organic cultivation of V. currassavica the spacing of 0.8 x 1.0 m and 1.0 m x 1.0 m, and the drying of its leaves between 40 and 50 °C to earn the highest essential oil yield and phytochemical quality.
DOI: 10.6084/m9.figshare.21137375.v1
title: Production and essential oil quality of Varroniacurassavica DC.submitted to different spacing between plants, harvest season and drying temperatures of leaves

description: ABSTRACT: Varroniacurassavica is a Brazilian native medicinal species. Among the critical points influencing the phytochemical quality of bioactive compounds is the spacing between plants, harvest and post-harvest. This research aimed evaluated the influence of plant distance, harvest season, and leaves drying temperature on the yield and phytochemical quality of V. curassavica essential oil. The organic cultivation was carried out in 2018/2019 using 0.6 x 1.0; 0.8 x 1.0; 1.0 x 1.0; 1.0 x 1.6 m spacing between plants. The macro and micronutrient contents of the leaves were evaluated and no considerable changes were observed. In 2018 the harvest was performed in summer, autumn, and winter, and the harvested leaves were immediately submitted to the drying process at 40 °C. In 2019 the harvest was performed in winter, and the leaves were submitted to the drying process at 40, 50, and 60 °C. The essential oil was extracted by hydrodistillation and the chemical constituents were evaluated using CG-MS. The essential oil yield was significantly higher in winter and used 0.8 x 1.0 m and 1.0 x 1.0 m spacing between plants. The alpha-humulene content remained within the recommended standards at all analyzed temperatures. Although, the drying temperatures tested did not compromise the alpha-humulene content, the increasing temperature caused a reduction in the essential oil yield. Thus, it is recommended for the organic cultivation of V. currassavica the spacing of 0.8 x 1.0 m and 1.0 m x 1.0 m, and the drying of its leaves between 40 and 50 °C to earn the highest essential oil yield and phytochemical quality.
DOI: 10.21227/gc4d-b330
title: face

description: face
DOI: 10.6084/m9.figshare.21161968
title: Abnormal Origin of the Pulmonary Artery from the Ascending Aorta in the Neonate

description: ABSTRACT The anomalous origin of one pulmonary artery from the ascending aorta is a rare congenital heart disease, generally diagnosed based on the clinical information and on echocardiographic and computed tomography angiography findings. Here we report two neonates successfully treated with surgery early in life.
DOI: 10.6084/m9.figshare.21161968.v1
title: Abnormal Origin of the Pulmonary Artery from the Ascending Aorta in the Neonate

description: ABSTRACT The anomalous origin of one pulmonary artery from the ascending aorta is a rare congenital heart disease, generally diagnosed based on the clinical information and on echocardiographic and computed tomography angiography findings. Here we report two neonates successfully treated with surgery early in life.
DOI: 10.6084/m9.figshare.21161970
title: Delayed diagnosis of homocystinuria presenting with coronavirus disease 2019 in a 17-year-old boy

description: ABSTRACT Homocystinuria is a treatable autosomal recessive inherited disorder. This condition may cause life-threatening complications such as thromboembolic events. Coronavirus disease 2019 (COVID-19) is associated with an increased risk of venous thromboembolic events. Here, we report a case of late diagnosis of homocystinuria presenting with deep venous thrombosis and COVID-19. This study highlights a sustained high index of suspicion for homocystinuria to prevent severe thromboembolic complications.
DOI: 10.6084/m9.figshare.21161970.v1
title: Delayed diagnosis of homocystinuria presenting with coronavirus disease 2019 in a 17-year-old boy

description: ABSTRACT Homocystinuria is a treatable autosomal recessive inherited disorder. This condition may cause life-threatening complications such as thromboembolic events. Coronavirus disease 2019 (COVID-19) is associated with an increased risk of venous thromboembolic events. Here, we report a case of late diagnosis of homocystinuria presenting with deep venous thrombosis and COVID-19. This study highlights a sustained high index of suspicion for homocystinuria to prevent severe thromboembolic complications.
DOI: 10.6084/m9.figshare.21161991
title: Characterization and mechanical properties of one-part geopolymer based on a pure metakaolin

description: Abstract Geopolymers are amorphous silicate polymers that have been extensively studied due to their applications, scientific and technical relevance, and their potential as cement in substitution to Portland. Much of the focus has been in the use of precursors and aggregates that are rarely pure and homogeneous with the use of tailings being very common. The presence of these impurities complicates the interpretation of some spectral methods, mainly infrared spectrometry. Therefore, this research focuses on the use of a nearly pure kaolin main precursor, having only a trace of iron and titanium, along with other almost pure reagents, to achieve an ideal geopolymer. It was possible to produce metakaolinite, resulting in a material with a good size particle (8.24µm) and surface specific area (6.57m2/g). The XRD result shows that the calcination process resulted in 100% of amorphous material. FTIR data revealed the presence of H2O and NaCO3 in the geopolymer. More important, the Si-Al-O various bands located between 1100 and 500cm-1 validate the polymerization reaction effectiveness. SEM-EDS analyses have demonstrated that the reaction with Na2SiO3 and NaOH were nearly complete, concerning the finer metakaolinite particles that comprised the material’s matrix. However, the coarser metakaolinite lamellae, in the 15-35µm range, did not react completely; a thin border layer was enriched with sodium and most of the interior material maintained its Si-Al-O composition. The presence of traces of iron and titanium did not influence in the polymerization reaction. Compressive strength values of the geopolymer have presented good values in the range of 25 to 35 MPa.
DOI: 10.6084/m9.figshare.21161991.v1
title: Characterization and mechanical properties of one-part geopolymer based on a pure metakaolin

description: Abstract Geopolymers are amorphous silicate polymers that have been extensively studied due to their applications, scientific and technical relevance, and their potential as cement in substitution to Portland. Much of the focus has been in the use of precursors and aggregates that are rarely pure and homogeneous with the use of tailings being very common. The presence of these impurities complicates the interpretation of some spectral methods, mainly infrared spectrometry. Therefore, this research focuses on the use of a nearly pure kaolin main precursor, having only a trace of iron and titanium, along with other almost pure reagents, to achieve an ideal geopolymer. It was possible to produce metakaolinite, resulting in a material with a good size particle (8.24µm) and surface specific area (6.57m2/g). The XRD result shows that the calcination process resulted in 100% of amorphous material. FTIR data revealed the presence of H2O and NaCO3 in the geopolymer. More important, the Si-Al-O various bands located between 1100 and 500cm-1 validate the polymerization reaction effectiveness. SEM-EDS analyses have demonstrated that the reaction with Na2SiO3 and NaOH were nearly complete, concerning the finer metakaolinite particles that comprised the material’s matrix. However, the coarser metakaolinite lamellae, in the 15-35µm range, did not react completely; a thin border layer was enriched with sodium and most of the interior material maintained its Si-Al-O composition. The presence of traces of iron and titanium did not influence in the polymerization reaction. Compressive strength values of the geopolymer have presented good values in the range of 25 to 35 MPa.
DOI: 10.6084/m9.figshare.21161998
title: A voyage to Argentina: the Asuero case and the illegal practice of medicine (Buenos Aires, 1930)

description: Abstract This article examines the activities of a well-known figure who, during his stay in Argentina, influenced life in Buenos Aires by cultivating his connections to medical science, the political sphere and the news media. The person in question was Fernando Asuero, an ear, nose and throat specialist from San Sebastián (Spain), whose activities in Buenos Aires in 1930 allow us to examine the conflicts within the healing arts, a field rife with competitors and numerous concurrent and opposing traditions. Using a biographical approach centered on a case study, this article shows that, at certain points, the disputes over cognitive monopoly ended up being debated within a courtroom.
DOI: 10.6084/m9.figshare.21161998.v1
title: A voyage to Argentina: the Asuero case and the illegal practice of medicine (Buenos Aires, 1930)

description: Abstract This article examines the activities of a well-known figure who, during his stay in Argentina, influenced life in Buenos Aires by cultivating his connections to medical science, the political sphere and the news media. The person in question was Fernando Asuero, an ear, nose and throat specialist from San Sebastián (Spain), whose activities in Buenos Aires in 1930 allow us to examine the conflicts within the healing arts, a field rife with competitors and numerous concurrent and opposing traditions. Using a biographical approach centered on a case study, this article shows that, at certain points, the disputes over cognitive monopoly ended up being debated within a courtroom.
DOI: 10.6084/m9.figshare.21162000
title: Unplanned dilution back analysis in an underground mine using numerical models

description: Abstract In underground mines, stability problems can cause unplanned dilution, increasing the costs of mining operations, such as loading, transport, crushing and grinding. This is usually dealt with by simply increasing investments with support. However, the design geometry of stopes and drifts also has a great effect on a stope’s stability. The use of empirical stability methods is a very common practice, however because of their few input parameters, it cannot predict the actual performance related to each stope and drift design. This study has as main goals a back analysis of the actual dilution, using the Equivalent Linear Overbreak Slough (ELOS) method and analysis in the drift developments at the hanging wall contact, using numerical models. The case study is an underground hard rock gold mine, with a pillar-less Transversal Stope method. The hanging wall failure was quantified using a database from 19 stopes measured by the Cavity Monitoring System (CMS). Numerical finite elements models (FEM) were used, and 5 primary stopes were selected to calibrate models. The volumes of actual dilution showed a good correlation with the volumes of the relaxation zones produced by the models. Then, new optimized drift geometry layouts at the hanging wall contact were proposed, showing a decrease in 2.35 times in the relaxation zone of the numerical models, therefore justifying the use of these models as a dilution optimization tool. This methodology also proved to be useful in the definition of cable bolt length.