cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.7616015.v2
title: Cross-cultural adaptation and psychometric properties of the Falls Efficacy Scale – International in Filipino community-dwelling older adults

description: <b>Purpose:</b> The Falls Efficacy Scale – International is universally used in assessing the level of concern about falling in older adults. The objectives of this study were to conduct a cross-cultural adaptation and to establish psychometric properties of Falls Efficacy Scale – International in Filipino (FES-I F). <b>Methods:</b> The standardized 10-step translation protocol of the Prevention of Falls Network Europe was followed. Community-dwelling older adults aged 60 or above (<i>N</i> = 211) from Manila, Philippines were recruited. The internal consistency and test–retest reliability of the translated tool was assessed. Convergent validity was compared with fall-related factors. The receiver operating characteristics were used to determine the cutoff score. <b>Results:</b> The FES-I F has high internal consistency (<i>α</i> = 0.91) and good test–retest reliability (intraclass correlation coefficient = 0.86). Overall scores were significantly higher among those with subjective report of fear of falling (<i>p</i> p = 0.014), slower gait speed (<i>p</i> = 0.003), and lower perceived well-being scores (<i>p</i> = 0.003) indicating acceptable convergent validity. The cutoff score of FES-I F was 22 points. <b>Conclusions</b>: The FES-I F has high internal reliability and acceptable validity, and can be a practical tool to measure the concern about falling in Filipino older adults. Future research is necessary to establish its utilization as an outcome measure in intervention studies.Implications for rehabilitationThe psychometric properties of the Filipino version of the Falls Efficacy Scale – International were good when assessed in older adults living in the community.The cutoff score to demarcate those with fear of falling from those without is 22 points.Falls Efficacy Scale – International in Filipino is recommended for the assessment of fear of falling for research and clinical purposes. The psychometric properties of the Filipino version of the Falls Efficacy Scale – International were good when assessed in older adults living in the community. The cutoff score to demarcate those with fear of falling from those without is 22 points. Falls Efficacy Scale – International in Filipino is recommended for the assessment of fear of falling for research and clinical purposes.
DOI: 10.6084/m9.figshare.7616015.v1
title: Cross-cultural adaptation and psychometric properties of the Falls Efficacy Scale – International in Filipino community-dwelling older adults

description: <b>Purpose:</b> The Falls Efficacy Scale – International is universally used in assessing the level of concern about falling in older adults. The objectives of this study were to conduct a cross-cultural adaptation and to establish psychometric properties of Falls Efficacy Scale – International in Filipino (FES-I F). <b>Methods:</b> The standardized 10-step translation protocol of the Prevention of Falls Network Europe was followed. Community-dwelling older adults aged 60 or above (<i>N</i> = 211) from Manila, Philippines were recruited. The internal consistency and test–retest reliability of the translated tool was assessed. Convergent validity was compared with fall-related factors. The receiver operating characteristics were used to determine the cutoff score. <b>Results:</b> The FES-I F has high internal consistency (<i>α</i> = 0.91) and good test–retest reliability (intraclass correlation coefficient = 0.86). Overall scores were significantly higher among those with subjective report of fear of falling (<i>p</i> p = 0.014), slower gait speed (<i>p</i> = 0.003), and lower perceived well-being scores (<i>p</i> = 0.003) indicating acceptable convergent validity. The cutoff score of FES-I F was 22 points. <b>Conclusions</b>: The FES-I F has high internal reliability and acceptable validity, and can be a practical tool to measure the concern about falling in Filipino older adults. Future research is necessary to establish its utilization as an outcome measure in intervention studies.Implications for rehabilitationThe psychometric properties of the Filipino version of the Falls Efficacy Scale – International were good when assessed in older adults living in the community.The cutoff score to demarcate those with fear of falling from those without is 22 points.Falls Efficacy Scale – International in Filipino is recommended for the assessment of fear of falling for research and clinical purposes. The psychometric properties of the Filipino version of the Falls Efficacy Scale – International were good when assessed in older adults living in the community. The cutoff score to demarcate those with fear of falling from those without is 22 points. Falls Efficacy Scale – International in Filipino is recommended for the assessment of fear of falling for research and clinical purposes.
DOI: 10.7284/125047
title: CTD (Conductivity, Temperature, Depth) data collected during research cruise EN577 using a Sea-Bird SBE-911+ instrument system onboard the platform RV Endeavor

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/136212
title: Meteorological Station data collected during research cruise PE19-09 using a RM Young 92000 instrument system onboard the platform RV Pelican

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/124977
title: GNSS (Global Navigation Satellite System) data collected during research cruise EN577 using a Furuno GP-90D instrument system onboard the platform RV Endeavor

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/136206
title: Transmissometer data collected during research cruise PE19-09 using a WET Labs C-Star instrument system onboard the platform RV Pelican

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/124978
title: GNSS (Global Navigation Satellite System) data collected during research cruise EN577 using a Northstar 952 instrument system onboard the platform RV Endeavor

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/136205
title: TSG (Thermosalinograph) data collected during research cruise PE19-09 using a Sea-Bird SBE-21 instrument system onboard the platform RV Pelican

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7615946
title: PhyDB.tax.txt

description: taxonomic map for a fasta database used for metabarcoding of Phytophthora species (ATP9-NAD9).<br>
DOI: 10.6084/m9.figshare.7615937
title: PlantsDB.fasta.gz

description: fasta sequences for plant species/genera identification (ITS2)
DOI: 10.6084/m9.figshare.7615943
title: PhyDB.fasta.gz

description: fasta sequences for Phytophthora species identification (ATP9-NAD9)<br>
DOI: 10.6084/m9.figshare.7615946.v1
title: PhyDB.tax.txt

description: taxonomic map for a fasta database used for metabarcoding of Phytophthora species (ATP9-NAD9).<br>
DOI: 10.7284/124981
title: Gyrocompass data collected during research cruise EN577 using a Sperry MK-37 instrument system onboard the platform RV Endeavor

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7615937.v1
title: PlantsDB.fasta.gz

description: fasta sequences for plant species/genera identification (ITS2)
DOI: 10.6084/m9.figshare.7615931
title: OmDB.fasta.gz

description: Fasta sequences for oomycete species/genera identification (ITS1)
DOI: 10.6084/m9.figshare.7615943.v2
title: PhyDB.fasta.gz

description: fasta sequences for Phytophthora species identification (ATP9-NAD9)<br>
DOI: 10.7284/124982
title: Gyrocompass data collected during research cruise EN577 using a Sperry MK-37 instrument system onboard the platform RV Endeavor

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7615943.v1
title: PhyDB.fasta.gz

description: fasta sequences for Phytophthora species identification (ATP9-NAD9)<br>
DOI: 10.6084/m9.figshare.7615898
title: PlantsDB.tax.tsv

description: taxonomic map for a fasta database used for metabarcoding of plant species (ITS2).
DOI: 10.6084/m9.figshare.7615931.v1
title: OmDB.fasta.gz

description: Fasta sequences for oomycete species/genera identification (ITS1)
DOI: 10.6084/m9.figshare.7615886
title: OmDB.tax.txt

description: taxonomic map for a fasta database used for metabarcoding of omycete species (ITS1).
DOI: 10.7284/125089
title: Meteorological Station data collected during research cruise EN577 using a RM Young 26800 instrument system onboard the platform RV Endeavor

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7615898.v1
title: PlantsDB.tax.tsv

description: taxonomic map for a fasta database used for metabarcoding of plant species (ITS2).
DOI: 10.7284/125086
title: Radiometer data collected during research cruise EN577 using a Eppley RAD instrument system onboard the platform RV Endeavor

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7615886.v1
title: OmDB.tax.txt

description: taxonomic map for a fasta database used for metabarcoding of omycete species (ITS1).
DOI: 10.6084/m9.figshare.7615898.v2
title: PlantsDB.tax.tsv

description: taxonomic map for a fasta database used for metabarcoding of plant species (ITS2).
DOI: 10.7284/125135
title: Radiometer data collected during research cruise EN577 using a Eppley RAD instrument system onboard the platform RV Endeavor

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/124983
title: Singlebeam Echosounder data collected during research cruise EN577 using a Knudsen 3260 instrument system onboard the platform RV Endeavor

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7615784
title: Loss of CDK5RAP2 affects neural but not non-neural mESC differentiation into cardiomyocytes

description: Biallelic mutations in the gene encoding centrosomal CDK5RAP2 lead to autosomal recessive primary microcephaly (MCPH), a disorder characterized by pronounced reduction in volume of otherwise architectonical normal brains and intellectual deficit. The current model for the microcephaly phenotype in MCPH invokes a premature shift from symmetric to asymmetric neural progenitor-cell divisions with a subsequent depletion of the progenitor pool. The isolated neural phenotype, despite the ubiquitous expression of CDK5RAP2, and reports of progressive microcephaly in individual MCPH cases prompted us to investigate neural and non-neural differentiation of <i>Cdk5rap2</i>-depleted and control murine embryonic stem cells (mESC). We demonstrate an accumulating proliferation defect of neurally differentiating <i>Cdk5rap2</i>-depleted mESC and cell death of proliferative and early postmitotic cells. A similar effect does not occur in non-neural differentiation into beating cardiomyocytes, which is in line with the lack of non-central nervous system features in MCPH patients. Our data suggest that MCPH is not only caused by premature differentiation of progenitors, but also by reduced propagation and survival of neural progenitors.
DOI: 10.6084/m9.figshare.7615790
title: Relative molar sensitivities of carnosol and carnosic acid with respect to diphenylamine allow accurate quantification of antioxidants in rosemary extract

description: We have been developing a high-performance liquid chromatography/photodiode array (HPLC/PDA) employing relative molar sensitivities (RMSs) and adopted it to the accurate quantification of carnosol (CL) and carnosic acid (CA) which are the antioxidants in rosemary extract. The method requires no references of CL or CA and instead uses RMSs with respect to diphenylamine (DPA) whose certified reference material is available from a reagent manufacturer. The molar and response ratios of the analytes to the reference in an artificial mixture of them were determined using <sup>1</sup>H-quantitative nuclear magnetic resonance spectroscopy (<sup>1</sup>H-qNMR) and HPLC/PDA at a wavelength of 284 nm under isocratic condition, respectively, and then RMSs were calculated to be 0.111 for CL/DPA and 0.0809 for CA/DPA as averaged values in three HPLC–PDA instruments. The RMS values varied by up to 1.1% as relative standard deviation. To evaluate the performance of HPLC/PDA with the RMSs, the CL and CA contents in rosemary extracts were determined using DPA as a reference. The CL and CA contents were compared with those determined using calibration curves of CL and CA obtained by HPLC measurement of standard solutions prepared from their reagents whose absolute purities were determined using <sup>1</sup>H-qNMR. The differences between the two methods for CL and CA were ≤3% as relative error. This chromatographic method with RMSs allows a simple and reliable quantification when reference of the analyte is unavailable.
DOI: 10.6084/m9.figshare.7615790.v1
title: Relative molar sensitivities of carnosol and carnosic acid with respect to diphenylamine allow accurate quantification of antioxidants in rosemary extract

description: We have been developing a high-performance liquid chromatography/photodiode array (HPLC/PDA) employing relative molar sensitivities (RMSs) and adopted it to the accurate quantification of carnosol (CL) and carnosic acid (CA) which are the antioxidants in rosemary extract. The method requires no references of CL or CA and instead uses RMSs with respect to diphenylamine (DPA) whose certified reference material is available from a reagent manufacturer. The molar and response ratios of the analytes to the reference in an artificial mixture of them were determined using <sup>1</sup>H-quantitative nuclear magnetic resonance spectroscopy (<sup>1</sup>H-qNMR) and HPLC/PDA at a wavelength of 284 nm under isocratic condition, respectively, and then RMSs were calculated to be 0.111 for CL/DPA and 0.0809 for CA/DPA as averaged values in three HPLC–PDA instruments. The RMS values varied by up to 1.1% as relative standard deviation. To evaluate the performance of HPLC/PDA with the RMSs, the CL and CA contents in rosemary extracts were determined using DPA as a reference. The CL and CA contents were compared with those determined using calibration curves of CL and CA obtained by HPLC measurement of standard solutions prepared from their reagents whose absolute purities were determined using <sup>1</sup>H-qNMR. The differences between the two methods for CL and CA were ≤3% as relative error. This chromatographic method with RMSs allows a simple and reliable quantification when reference of the analyte is unavailable.
DOI: 10.7284/125058
title: TSG (Thermosalinograph) data collected during research cruise EN577 using a Sea-Bird SBE-45 instrument system onboard the platform RV Endeavor

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7615763
title: Efficacy and tolerability of EH301 for amyotrophic lateral sclerosis: a randomized, double-blind, placebo-controlled human pilot study

description: <i>Background</i>: Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease, characterized by progressive loss of spinal and cortical motor neurons, leading to muscular atrophy, respiratory failure, and ultimately death. There is no known cure, and the clinical benefit of the two drugs approved to treat ALS remains unclear. Novel disease-modifying therapeutics that are able to modulate the disease course are desperately needed. Our objective was to evaluate the efficacy and tolerability of Elysium Health’s candidate drug EH301 in people with ALS (PALS). <i>Methods</i>: This was a single-center, prospective, double-blind, randomized, placebo-controlled pilot study. Thirty-two PALS were recruited thanks to the collaboration of the Spanish Foundation for ALS Research (FUNDELA). Study participants were randomized to receive either EH301 or placebo and underwent evaluation for 4 months. Differences between EH301 and placebo-treated participants were evaluated based on standard clinical endpoints, including the revised ALS functional rating scale (ALSFRS-R), forced vital capacity (FVC), and the Medical Research Council (MRC) grading scale. <i>Results</i>: Compared to placebo, participants treated with EH301 demonstrated significant improvements in the ALSFRS-R score, pulmonary function, muscular strength, and in skeletal muscle/fat weight ratio. EH301 was shown to significantly slow the progression of ALS relative to placebo, and even showed improvements in several key outcome measures compared with baseline. <i>Conclusions</i>: This study provides evidence in support of the disease-modifying effects of EH301 for the treatment of ALS. <b>Trial registration:</b>ClinicalTrials.gov identifier: NCT03489200.
DOI: 10.7284/125059
title: TSG (Thermosalinograph) data collected during research cruise EN577 using a Sea-Bird SBE-21 instrument system onboard the platform RV Endeavor

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7615760
title: brazilian_politics_tweets_id.txt

description: We collected more than 1M of public tweets of 692 Brazilian deputies from October 2013 toOctober 2015 by means of the Twitter API (Application Programming Interface).The names of the active congressmen during this period were retrieved and validated by a researcher in March 2015.
DOI: 10.6084/m9.figshare.7615784.v1
title: Loss of CDK5RAP2 affects neural but not non-neural mESC differentiation into cardiomyocytes

description: Biallelic mutations in the gene encoding centrosomal CDK5RAP2 lead to autosomal recessive primary microcephaly (MCPH), a disorder characterized by pronounced reduction in volume of otherwise architectonical normal brains and intellectual deficit. The current model for the microcephaly phenotype in MCPH invokes a premature shift from symmetric to asymmetric neural progenitor-cell divisions with a subsequent depletion of the progenitor pool. The isolated neural phenotype, despite the ubiquitous expression of CDK5RAP2, and reports of progressive microcephaly in individual MCPH cases prompted us to investigate neural and non-neural differentiation of <i>Cdk5rap2</i>-depleted and control murine embryonic stem cells (mESC). We demonstrate an accumulating proliferation defect of neurally differentiating <i>Cdk5rap2</i>-depleted mESC and cell death of proliferative and early postmitotic cells. A similar effect does not occur in non-neural differentiation into beating cardiomyocytes, which is in line with the lack of non-central nervous system features in MCPH patients. Our data suggest that MCPH is not only caused by premature differentiation of progenitors, but also by reduced propagation and survival of neural progenitors.
DOI: 10.7284/124987
title: ADCP (Acoustic Doppler Current Profiler) data collected during research cruise EN578 using a Hawaii UHDAS instrument system onboard the platform RV Endeavor

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7615760.v1
title: brazilian_politics_tweets_id.txt

description: We collected more than 1M of public tweets of 692 Brazilian deputies from October 2013 toOctober 2015 by means of the Twitter API (Application Programming Interface).The names of the active congressmen during this period were retrieved and validated by a researcher in March 2015.
DOI: 10.6084/m9.figshare.7615754
title: Effect of diet on oxygen uptake rate in the talitrid amphipod <i>Platorchestia platensis</i>

description: The primary ecotope for <i>Platorchestia platensis</i> is supralittoral wrack, but occasionally this species may be found living in, and feeding on, rotting driftwood as a secondary ecotope. Lower oxygen uptake rates were measured for driftwood-fed compared with wrack-fed <i>P. platensis</i>. The null hypothesis that the metabolic rate in <i>P. platensis</i> would remain unchanged after reversing the diet from driftwood to wrack was rejected. Diet reversal experiments demonstrated that the oxygen consumption rates of <i>P. platensis</i> were reversible and gradually attained. This is consistent with the change of diet from wrack to driftwood, or vice versa, causing physiological changes involving oxygen consumption in <i>P. platensis</i>, which are described as acclimation rather than adaptation.
DOI: 10.7284/125091
title: Anemometer data collected during research cruise EN578 using a RM Young 05103 instrument system onboard the platform RV Endeavor

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7615754.v1
title: Effect of diet on oxygen uptake rate in the talitrid amphipod <i>Platorchestia platensis</i>

description: The primary ecotope for <i>Platorchestia platensis</i> is supralittoral wrack, but occasionally this species may be found living in, and feeding on, rotting driftwood as a secondary ecotope. Lower oxygen uptake rates were measured for driftwood-fed compared with wrack-fed <i>P. platensis</i>. The null hypothesis that the metabolic rate in <i>P. platensis</i> would remain unchanged after reversing the diet from driftwood to wrack was rejected. Diet reversal experiments demonstrated that the oxygen consumption rates of <i>P. platensis</i> were reversible and gradually attained. This is consistent with the change of diet from wrack to driftwood, or vice versa, causing physiological changes involving oxygen consumption in <i>P. platensis</i>, which are described as acclimation rather than adaptation.
DOI: 10.6084/m9.figshare.7615763.v1
title: Efficacy and tolerability of EH301 for amyotrophic lateral sclerosis: a randomized, double-blind, placebo-controlled human pilot study

description: <i>Background</i>: Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease, characterized by progressive loss of spinal and cortical motor neurons, leading to muscular atrophy, respiratory failure, and ultimately death. There is no known cure, and the clinical benefit of the two drugs approved to treat ALS remains unclear. Novel disease-modifying therapeutics that are able to modulate the disease course are desperately needed. Our objective was to evaluate the efficacy and tolerability of Elysium Health’s candidate drug EH301 in people with ALS (PALS). <i>Methods</i>: This was a single-center, prospective, double-blind, randomized, placebo-controlled pilot study. Thirty-two PALS were recruited thanks to the collaboration of the Spanish Foundation for ALS Research (FUNDELA). Study participants were randomized to receive either EH301 or placebo and underwent evaluation for 4 months. Differences between EH301 and placebo-treated participants were evaluated based on standard clinical endpoints, including the revised ALS functional rating scale (ALSFRS-R), forced vital capacity (FVC), and the Medical Research Council (MRC) grading scale. <i>Results</i>: Compared to placebo, participants treated with EH301 demonstrated significant improvements in the ALSFRS-R score, pulmonary function, muscular strength, and in skeletal muscle/fat weight ratio. EH301 was shown to significantly slow the progression of ALS relative to placebo, and even showed improvements in several key outcome measures compared with baseline. <i>Conclusions</i>: This study provides evidence in support of the disease-modifying effects of EH301 for the treatment of ALS.
DOI: 10.7284/125092
title: Anemometer data collected during research cruise EN578 using a RM Young 05103 instrument system onboard the platform RV Endeavor

description: Original (unprocessed) data collected during a Field_expedition