cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.5907733.v1
title: DFT STUDY ON THE MECHANISTIC, ENERGETIC AND STRUCTURAL ASPECTS OF ADSORPTION OF TIRAPAZAMINE ONTO PRISTINE AND FUNCTIONALIZED CARBON NANOTUBES

description: Using density functional theory, noncovalent interactions and two mechanisms of covalent functionalization of drug tirapazamine with pristine, COOH and COCl functionalized carbon nanotube (NT, NTCOOH and NTCOCl) have been investigated. Quantum molecular descriptors of noncovalent configurations were studied. It was specified that binding of drug tirapazamine with NTCOOH has more binding energy than NTCOCl and NT, so NTCOOH can act as a favorable system for tirapazamine drug delivery within biological and chemical systems (noncovalent). NTCOOH and NTCOCl can bond to the amino group of tirapazamine through OH (COOH mechanism) and Cl (COCl mechanism) groups, respectively. The activation parameters of two pathways were calculated and compared with each other. The activation parameters related to COOH mechanism are higher than those related to COCl mechanism and therefore COCl mechanism is suitable for covalent functionalization. These results could be generalized to other similar drugs.
DOI: 10.6084/m9.figshare.5907730
title: Alkaline Solubilization of Chicken Tissues Monitored by Raman Spectroscopy Followed by Pb Determination by GF AAS

description: This paper proposes a method for chicken tissues preparation using tetramethylammonium hydroxide (TMAH) for Pb determination by graphite furnace atomic absorption spectrometry employing multivariate approaches. Combining Raman spectroscopy with scanning electron microscopy coupled to energy-dispersive X-ray spectroscopy to monitor the solubilization process it was possible to show that TMAH acts in the solubilization of proteins, amino acids and lipids. Besides, this investigation showed that the small residual masses of samples have organic and inorganic compounds. Accuracy tests indicated that such residues have not interfered in the analytical results (recovery between 90-95%). The obtained limits of detection (0.099 µg g -1) and quantification (0.33 µg g -1) are compatible with the detectability required for regulatory purposes. Linearity (R2 = 0.9925) and characteristic mass (13 pg) were also reported. Considering the set of 15 samples comercialized in Brazil, any Pb contamination was successfully observed and this was confirmed by the analysis of digested samples.
DOI: 10.6084/m9.figshare.5907730.v1
title: Alkaline Solubilization of Chicken Tissues Monitored by Raman Spectroscopy Followed by Pb Determination by GF AAS

description: This paper proposes a method for chicken tissues preparation using tetramethylammonium hydroxide (TMAH) for Pb determination by graphite furnace atomic absorption spectrometry employing multivariate approaches. Combining Raman spectroscopy with scanning electron microscopy coupled to energy-dispersive X-ray spectroscopy to monitor the solubilization process it was possible to show that TMAH acts in the solubilization of proteins, amino acids and lipids. Besides, this investigation showed that the small residual masses of samples have organic and inorganic compounds. Accuracy tests indicated that such residues have not interfered in the analytical results (recovery between 90-95%). The obtained limits of detection (0.099 µg g -1) and quantification (0.33 µg g -1) are compatible with the detectability required for regulatory purposes. Linearity (R2 = 0.9925) and characteristic mass (13 pg) were also reported. Considering the set of 15 samples comercialized in Brazil, any Pb contamination was successfully observed and this was confirmed by the analysis of digested samples.
DOI: 10.6084/m9.figshare.5907724
title: Aqueous Nanofluids Based on Copper MPA: Synthesis and Characterization

description: The application and use of efficient cooling fluids have become increasingly important due to the increasing industrial and energy demand associated with the miniaturization of various electronic devices. The search for high-efficiency heat exchanger fluids in the early 1990s led to the development of a new class of refrigerants called nanofluids. The use of nanofluids is linked to obtaining stable colloidal dispersions which exhibit high thermal conductivity. For this purpose, the efficiency of a nanofluid will depend on the type of fluid used and the dispersed nanomaterial. In this work, a stable aqueous nanofluid based on mercaptopropionic acid-coated copper sulfide nanoparticles (Cu2S/MPA), synthesized by the chemical reduction method, was developed. The nanofluid presented colloidal stability in alkaline medium and an average increase of 36% in thermal conductivity for a volumetric fraction of 0.05%.
DOI: 10.6084/m9.figshare.5907724.v1
title: Aqueous Nanofluids Based on Copper MPA: Synthesis and Characterization

description: The application and use of efficient cooling fluids have become increasingly important due to the increasing industrial and energy demand associated with the miniaturization of various electronic devices. The search for high-efficiency heat exchanger fluids in the early 1990s led to the development of a new class of refrigerants called nanofluids. The use of nanofluids is linked to obtaining stable colloidal dispersions which exhibit high thermal conductivity. For this purpose, the efficiency of a nanofluid will depend on the type of fluid used and the dispersed nanomaterial. In this work, a stable aqueous nanofluid based on mercaptopropionic acid-coated copper sulfide nanoparticles (Cu2S/MPA), synthesized by the chemical reduction method, was developed. The nanofluid presented colloidal stability in alkaline medium and an average increase of 36% in thermal conductivity for a volumetric fraction of 0.05%.
DOI: 10.6084/m9.figshare.5907721
title: THE USE OF HYDROGEL COMBINED WITH APPROPRIATE SUBSTRATE AND FERTILIZER IMPROVE QUALITY AND GROWTH PERFORMANCE OF Mimosa scabrella BENTH. SEEDLINGS

description: ABSTRACT Mimosa scabrella is a pioneer species that occurs mainly in the ombrophilous mixed forests of southern Brazil, assuming considerable economic relevance. As limited information is available concerning the most adequate substrates for producing seedlings of this species, we evaluated the combined effect of hydrogel with three types of substrates and four fertilizers in the initial growth and quality of seedlings of M. scabrella. The substrates were prepared with distinct proportions of a commercial organic substrate, vermiculite (VM) and pine bark (PB): 1 (70% of TF, 10% of VM and 20% of PB), 2 (40% of each TF and VM and 20% of PB), and 3 (70% of TF, 10% of VM and 20% of PB). The fertilizers consisted of a slow release formula (A), a traditional NPK (B), a compost of superphosphate and potassium chloride (C) and no fertilizer (D). The three soil mixtures were combined with each fertilizer in the presence or absence of hydrogel (factorial arrangement). The use of hydrogel promoted a positive effect on the growth of M. scabrella seedlings, probably by retaining more water and enabling increased nutrient absorption. In general, the polymer implicated in increased Dickson quality index (DQI). Additionally, the combination of organic compound and vermiculite in equilibrated proportions aid by pinus bark (substrate 2) were the best substrate. Finally, adding the fertilizers A or B resulted in the best growth performance. In conclusion, the combined effect of hydrogel, substrate mixture and fertilizers improved the quality indexes of M. scabrella seedlings.
DOI: 10.6084/m9.figshare.5907721.v1
title: THE USE OF HYDROGEL COMBINED WITH APPROPRIATE SUBSTRATE AND FERTILIZER IMPROVE QUALITY AND GROWTH PERFORMANCE OF Mimosa scabrella BENTH. SEEDLINGS

description: ABSTRACT Mimosa scabrella is a pioneer species that occurs mainly in the ombrophilous mixed forests of southern Brazil, assuming considerable economic relevance. As limited information is available concerning the most adequate substrates for producing seedlings of this species, we evaluated the combined effect of hydrogel with three types of substrates and four fertilizers in the initial growth and quality of seedlings of M. scabrella. The substrates were prepared with distinct proportions of a commercial organic substrate, vermiculite (VM) and pine bark (PB): 1 (70% of TF, 10% of VM and 20% of PB), 2 (40% of each TF and VM and 20% of PB), and 3 (70% of TF, 10% of VM and 20% of PB). The fertilizers consisted of a slow release formula (A), a traditional NPK (B), a compost of superphosphate and potassium chloride (C) and no fertilizer (D). The three soil mixtures were combined with each fertilizer in the presence or absence of hydrogel (factorial arrangement). The use of hydrogel promoted a positive effect on the growth of M. scabrella seedlings, probably by retaining more water and enabling increased nutrient absorption. In general, the polymer implicated in increased Dickson quality index (DQI). Additionally, the combination of organic compound and vermiculite in equilibrated proportions aid by pinus bark (substrate 2) were the best substrate. Finally, adding the fertilizers A or B resulted in the best growth performance. In conclusion, the combined effect of hydrogel, substrate mixture and fertilizers improved the quality indexes of M. scabrella seedlings.
DOI: 10.6084/m9.figshare.5907718
title: High-Intensity Interval Training in Heart Transplant Recipients: A Systematic Review with Meta-Analysis

description: Abstract Heart transplantation (HTx) is considered an efficient and gold-standard procedure for patients with end-stage heart failure. After surgery, patients have lower aerobic power (VO2max) and compensatory hemodynamic responses. The aim of the present study was to assess through a systematic review with meta-analysis whether high-intensity interval training (HIIT) can provide benefits for those parameters. This is a systematic review with meta-analysis, which searched the databases and data portals PubMed, Web of Science, Scopus, Science Direct and Wiley until December 2016 (pairs). The following terms and descriptors were used: “heart recipient” OR “heart transplant recipient” OR ”heart transplant” OR “cardiac transplant” OR “heart graft”. Descriptors via DeCS and Mesh were: “heart transplantation’’ OR “cardiac transplantation”. The words used in combination (AND) were: “exercise training” OR “interval training” OR “high intensity interval training” OR “high intensity training” OR “anaerobic training” OR “intermittent training” OR “sprint training”. The initial search identified 1064 studies. Then, only those studies assessing the influence of HIIT on the post-HTx period were added, resulting in three studies analyzed. The significance level adopted was 0.05. Heart transplant recipients showed significant improvement in VO2peak, heart rate and peak blood pressure in 8 to 12 weeks of intervention.
DOI: 10.6084/m9.figshare.5907718.v1
title: High-Intensity Interval Training in Heart Transplant Recipients: A Systematic Review with Meta-Analysis

description: Abstract Heart transplantation (HTx) is considered an efficient and gold-standard procedure for patients with end-stage heart failure. After surgery, patients have lower aerobic power (VO2max) and compensatory hemodynamic responses. The aim of the present study was to assess through a systematic review with meta-analysis whether high-intensity interval training (HIIT) can provide benefits for those parameters. This is a systematic review with meta-analysis, which searched the databases and data portals PubMed, Web of Science, Scopus, Science Direct and Wiley until December 2016 (pairs). The following terms and descriptors were used: “heart recipient” OR “heart transplant recipient” OR ”heart transplant” OR “cardiac transplant” OR “heart graft”. Descriptors via DeCS and Mesh were: “heart transplantation’’ OR “cardiac transplantation”. The words used in combination (AND) were: “exercise training” OR “interval training” OR “high intensity interval training” OR “high intensity training” OR “anaerobic training” OR “intermittent training” OR “sprint training”. The initial search identified 1064 studies. Then, only those studies assessing the influence of HIIT on the post-HTx period were added, resulting in three studies analyzed. The significance level adopted was 0.05. Heart transplant recipients showed significant improvement in VO2peak, heart rate and peak blood pressure in 8 to 12 weeks of intervention.
DOI: 10.6084/m9.figshare.5907712
title: Suspended and Immobilized TiO2 Photocatalytic Degradation of Estrogens: Potential for Application in Wastewater Treatment Processes

description: This work evaluated the photocatalytic activity of suspended TiO2, and TiO2-coated glass Raschig rings with respect to degradation of estrogens estrone (E1), 17β-estradiol (E2), and 17α-ethinylestradiol (EE2) in aqueous solutions and wastewater effluent samples. Gas chromatography/tandem mass spectrometry (GC-MS/MS) studies were carried out to identify degradation products for EE2. TiO2 suspensions allowed degradation rates higher than 90% for all studied estrogens in 30 min for an artificial (ultraviolet A) UVA-assisted process and aqueous solution. Immobilized TiO2 showed less favorable degradation kinetics, requiring ca. 60 min to achieve almost complete estrogen degradation. Some derivatized degradation products were identified for the first time by GC-MS/MS applying ultraviolet C (UVC) photolysis and TiO2/UVA photocatalysis. A degradation route was suggested for EE2 in UVC photolysis and TiO2/UVA processes. In the degradation of pretreated sewage samples, the immobilized TiO2 was more efficient than free TiO2, allowing ca. 85% removal of E2 and EE2 in 60 min.
DOI: 10.6084/m9.figshare.5907712.v1
title: Suspended and Immobilized TiO2 Photocatalytic Degradation of Estrogens: Potential for Application in Wastewater Treatment Processes

description: This work evaluated the photocatalytic activity of suspended TiO2, and TiO2-coated glass Raschig rings with respect to degradation of estrogens estrone (E1), 17β-estradiol (E2), and 17α-ethinylestradiol (EE2) in aqueous solutions and wastewater effluent samples. Gas chromatography/tandem mass spectrometry (GC-MS/MS) studies were carried out to identify degradation products for EE2. TiO2 suspensions allowed degradation rates higher than 90% for all studied estrogens in 30 min for an artificial (ultraviolet A) UVA-assisted process and aqueous solution. Immobilized TiO2 showed less favorable degradation kinetics, requiring ca. 60 min to achieve almost complete estrogen degradation. Some derivatized degradation products were identified for the first time by GC-MS/MS applying ultraviolet C (UVC) photolysis and TiO2/UVA photocatalysis. A degradation route was suggested for EE2 in UVC photolysis and TiO2/UVA processes. In the degradation of pretreated sewage samples, the immobilized TiO2 was more efficient than free TiO2, allowing ca. 85% removal of E2 and EE2 in 60 min.
DOI: 10.6084/m9.figshare.5907709
title: Study of the Young's Modulus in Microstructures through the Resonance Frequency Technique for Applications in Commercial CMOS Processes

description: The companies that manufacture devices with techniques inherited from microelectronics, called foundries, generally provide the electrical characteristics of the layers of their manufacturing processes, but they do not provide the mechanical parameters, which prevents the mechanical optimization of any design used in this manufacturing. Thus, the extraction of mechanical properties from the layers of a commercial process is important and it requires specific techniques and microstructures for this purpose. This work presents a study on the Young's modulus of cooper thin films using the resonance frequency technique to extract this parameter. The microstructures used for the application of the technique are cooper cantilevers with lengths of 100-700 µm, width 40 µm and thickness 2 µm suspended in such a way that it is possible to measure their resonant frequency. These structures are also simulated using the finite element method. The experimental results are compared with the simulations and presented equivalence.
DOI: 10.6084/m9.figshare.5907709.v1
title: Study of the Young's Modulus in Microstructures through the Resonance Frequency Technique for Applications in Commercial CMOS Processes

description: The companies that manufacture devices with techniques inherited from microelectronics, called foundries, generally provide the electrical characteristics of the layers of their manufacturing processes, but they do not provide the mechanical parameters, which prevents the mechanical optimization of any design used in this manufacturing. Thus, the extraction of mechanical properties from the layers of a commercial process is important and it requires specific techniques and microstructures for this purpose. This work presents a study on the Young's modulus of cooper thin films using the resonance frequency technique to extract this parameter. The microstructures used for the application of the technique are cooper cantilevers with lengths of 100-700 µm, width 40 µm and thickness 2 µm suspended in such a way that it is possible to measure their resonant frequency. These structures are also simulated using the finite element method. The experimental results are compared with the simulations and presented equivalence.
DOI: 10.6084/m9.figshare.5907706
title: Heart Transplantation for Peripartum Cardiomyopathy: A Single-Center Experience

description: Abstract Background: Peripartum cardiomyopathy is an idiopathic disorder defined by the occurrence of acute heart failure during late pregnancy or post-partum period in the absence of any other definable cause. Its clinical course is variable and severe cases might require heart transplantation. Objective: To investigate long-term outcomes after heart transplantation (HT) for peripartum cardiomyopathy (PPCM). Methods: Out of a single-center series of 1938 HT, 14 HT were performed for PPCM. We evaluated clinical characteristics, transplant-related complications, and long-term outcomes, in comparison with 28 sex-matched controls. Primary endpoint was death from any cause; secondary endpoints were transplant-related complications (rejection, infection, cardiac allograft vasculopathy). A value of p &lt; 0.05 was considered of statistical significance. Results: PPCM patients and matched controls were comparable for most variables (all p values &gt; 0.05), except for a higher use of inotropes at the time of HT in PPCM group (p = 0.03). During a median follow-up of 7.7 years, 16 patients died, 3 (21.5%) in PPCM group and 13 (46.5%) in control group. Mortality was significantly lower in PPCM group (p = 0.03). No significant difference was found in terms of transplant-related complications (p &gt; 0.05). Conclusions: Long-term outcomes following HT for PPCM are favorable. Heart transplantation is a valuable option for PPCM patients who did not recover significantly under medical treatment.
DOI: 10.6084/m9.figshare.5907706.v1
title: Heart Transplantation for Peripartum Cardiomyopathy: A Single-Center Experience

description: Abstract Background: Peripartum cardiomyopathy is an idiopathic disorder defined by the occurrence of acute heart failure during late pregnancy or post-partum period in the absence of any other definable cause. Its clinical course is variable and severe cases might require heart transplantation. Objective: To investigate long-term outcomes after heart transplantation (HT) for peripartum cardiomyopathy (PPCM). Methods: Out of a single-center series of 1938 HT, 14 HT were performed for PPCM. We evaluated clinical characteristics, transplant-related complications, and long-term outcomes, in comparison with 28 sex-matched controls. Primary endpoint was death from any cause; secondary endpoints were transplant-related complications (rejection, infection, cardiac allograft vasculopathy). A value of p &lt; 0.05 was considered of statistical significance. Results: PPCM patients and matched controls were comparable for most variables (all p values &gt; 0.05), except for a higher use of inotropes at the time of HT in PPCM group (p = 0.03). During a median follow-up of 7.7 years, 16 patients died, 3 (21.5%) in PPCM group and 13 (46.5%) in control group. Mortality was significantly lower in PPCM group (p = 0.03). No significant difference was found in terms of transplant-related complications (p &gt; 0.05). Conclusions: Long-term outcomes following HT for PPCM are favorable. Heart transplantation is a valuable option for PPCM patients who did not recover significantly under medical treatment.
DOI: 10.6084/m9.figshare.5907700
title: Moderate Continuous Aerobic Exercise Training Improves Cardiomyocyte Contractility in Β1 Adrenergic Receptor Knockout Mice

description: Abstract Background: The lack of cardiac β1-adrenergic receptors (β1-AR) negatively affects the regulation of both cardiac inotropy and lusitropy, leading, in the long term, to heart failure (HF). Moderate-intensity aerobic exercise (MCAE) is recommended as an adjunctive therapy for patients with HF. Objective: We tested the effects of MCAE on the contractile properties of left ventricular (LV) myocytes from β1 adrenergic receptor knockout (β1ARKO) mice. Methods: Four- to five-month-old male wild type (WT) and β1ARKO mice were divided into groups: WT control (WTc) and trained (WTt); and β1ARKO control (β1ARKOc) and trained (β1ARKOt). Animals from trained groups were submitted to a MCAE regimen (60 min/day; 60% of maximal speed, 5 days/week) on a treadmill, for 8 weeks. P ≤ 0.05 was considered significant in all comparisons. Results: The β1ARKO and exercised mice exhibited a higher (p &lt; 0.05) running capacity than WT and sedentary ones, respectively. The β1ARKO mice showed higher body (BW), heart (HW) and left ventricle (LVW) weights, as well as the HW/BW and LVW/BW than WT mice. However, the MCAE did not affect these parameters. Left ventricular myocytes from β1ARKO mice showed increased (p &lt; 0.05) amplitude and velocities of contraction and relaxation than those from WT. In addition, MCAE increased (p &lt; 0.05) amplitude and velocities of contraction and relaxation in β1ARKO mice. Conclusion: MCAE improves myocyte contractility in the left ventricle of β1ARKO mice. This is evidence to support the therapeutic value of this type of exercise training in the treatment of heart diseases involving β1-AR desensitization or reduction.