cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.7941710.v1
title: Development of a Brazilian anticholinergic activity drug scale

description: ABSTRACT Objective To develop a scale of anticholinergic activity drugs used in Brazil, to be applied in health care and pharmacoepidemiology research. Methods We performed a literature review on PubMed/MEDLINE® to identify previously published scales of anticholinergic drugs. This scale started with anticholinergic drugs, and those with known anticholinergic activity as per the 4th level, chemical-therapeutic subgroup, of the Anatomical Therapeutic Chemical classification. We also included drugs with high anticholinergic activity, as described in a list of potentially inappropriate medications for use in older adults, according to the 2015 American Geriatrics Society Beers Criteria. Drugs listed in at least two anticholinergic scales were added. Then we verified which drugs in the previous steps were marketed in Brazil. We assigned a score of 1, 2 and 3, based on their anticholinergic action. Results A total of 273 anticholinergic drugs were identified, of which 125 were included in the scale. We identified 45 (36.0%) drugs with a score of 3, 13 (10.4%) with a score of 2, and 67 (53.6%) with a score of 1. Drugs for the nervous and respiratory systems were the most frequent in the scale. Eight drugs were not present in previous scales. Conclusion The methodology used for development of the Brazilian anticholinergic activity scale is simple, systematized, reproducible and easy to update. The scale allows evaluating the impact of anticholinergic burden on health outcomes, and can potentially contribute to pharmacoepidemiology research, leading to more accurate measurements of anticholinergic activity.
DOI: 10.34808/zvnw-cs19
title: Malignant neoplasm of testis - Male, 27 - Tissue image [6080730009645291]

description: This is the histopathological image of TESTIS tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format. The detailed information about the patient, sample, and diagnosis are as follows: Patient:Age: 27Clinical description: Tumour of the left testicleGender: MaleDiagnosis:Classification: ICD-10_10-20Classification code: Chapter II - NeoplasmsDiagnosis: Malignant neoplasm of testisResult of the histopathological examination: Mixed testicular germ cell tumor, which includes seminoma, germ cell carcinoma and yolk sac tumor. Diffuse intratubular germ cell neoplasia in the adjacent parenchyma. Seminoma  accounts for approximately 60% of malignant uterus, 35% of germ cell carcinoma and 5% of yolk sac tumour. Germ cell carcinoma  with areas of extensive necrosis (about 70-80% of its tissue).
The seminoma focally infiltrates the testicle network. The tumor is confined to the testicle parenchyma and does not infiltrate the lining.
Vascular invasion has not been identified.
IHC: seminoma-OCT 3/4 (+), germ cell carcinoma -OCT 3/4 (+), CD 30 (+), beta HCG (-), Glipican 3 (-), AFP (-), yolk sac tumor -AFP (+), Glipican 3 (+).Sample:Material: FFPECollecting method: Surgical specimenTopography: MALE GENITAL ORGANSOrgan: TESTISTissue: Testis, NOSType of staining: positive/IHCStaining: Not applicableAntibody: Glypican-3Technology:Equipment: Pannoramic 250 3DHistechLens: 20xOrganization:Source: Medical University Gdańsk
DOI: 10.34808/2hpc-5120
title: Nonspecific lymphadenitis - Female, 16 - Tissue image [6080730009659811]

description: This is the histopathological image of LYMPH NODES tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format. The detailed information about the patient, sample, and diagnosis are as follows: Patient:Age: 16Clinical description: Gender: FemaleDiagnosis:Classification: ICD-10_10-20Classification code: Chapter IX - Diseases of the circulatory systemDiagnosis: Nonspecific lymphadenitisResult of the histopathological examination: Sample:Material: FFPECollecting method: Surgical specimenTopography: LYMPH NODESOrgan: LYMPH NODESTissue: Submandibular lymph nodeType of staining: positive/IHCStaining: Not applicableAntibody: CD 45 (LCA)Technology:Equipment: Pannoramic 250 3DHistechLens: 20xOrganization:Source: Medical University Gdańsk
DOI: 10.6084/m9.figshare.7941539
title: Electrocardiographic changes in spondyloarthritis and use of anti-TNF-α drugs: a retrospective study with 100 patients

description: ABSTRACT Objective To investigate the prevalence of electrocardiographic changes in patients with spondyloarthritis and to correlate these changes with use of anti-tumor necrosis factor-alpha (TNF-α) drugs and HLA-B27 positivity. Methods Retrospective study including 100 patients diagnosed with spondyloarthritis according to Assessment of SpondyloArthritis International Society (ASAS) criteria and 50 controls. Epidemiological and clinical features, results of inflammatory activity tests, HLA-B27 positivity, and medication use data were extracted from medical records. Disease activity was assessed using the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI). All participants were submitted to electrocardiogram performed using a 12-lead device; rhythm, heart rate, conduction disorders and QT interval corrected using the Bazett formula were analyzed. Results Of 100 patients with spondyloarthritis, 51 were on anti-TNF-α drugs and 49 were not. HLA-B27 was detected in 53.1% of patients in the sample. Patients with spondyloarthritis had lower heart rate (p=0.06), longer QT interval (p&lt;0.0001) and higher prevalence of right bundle branch block (p=0.014) compared to controls. Duration of disease was weakly correlated with heart rate (Rho=0.26; 95%CI: 0.06-0.44; p=0.008). The prevalence of right bundle branch block was positively correlated with HLA-B27 positivity. Use of Anti-TNF-α drugs did not interfere with electrocardiographic parameters. Conclusion Patients with spondyloarthritis had lower heart rate, longer QT interval and a higher prevalence of right bundle branch block compared to controls. HLA-B27 positivity was associated with the prevalence of right bundle branch block. Anti-TNF-α drugs had no impact on electrocardiographic findings.
DOI: 10.6084/m9.figshare.7941539.v1
title: Electrocardiographic changes in spondyloarthritis and use of anti-TNF-α drugs: a retrospective study with 100 patients

description: ABSTRACT Objective To investigate the prevalence of electrocardiographic changes in patients with spondyloarthritis and to correlate these changes with use of anti-tumor necrosis factor-alpha (TNF-α) drugs and HLA-B27 positivity. Methods Retrospective study including 100 patients diagnosed with spondyloarthritis according to Assessment of SpondyloArthritis International Society (ASAS) criteria and 50 controls. Epidemiological and clinical features, results of inflammatory activity tests, HLA-B27 positivity, and medication use data were extracted from medical records. Disease activity was assessed using the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI). All participants were submitted to electrocardiogram performed using a 12-lead device; rhythm, heart rate, conduction disorders and QT interval corrected using the Bazett formula were analyzed. Results Of 100 patients with spondyloarthritis, 51 were on anti-TNF-α drugs and 49 were not. HLA-B27 was detected in 53.1% of patients in the sample. Patients with spondyloarthritis had lower heart rate (p=0.06), longer QT interval (p&lt;0.0001) and higher prevalence of right bundle branch block (p=0.014) compared to controls. Duration of disease was weakly correlated with heart rate (Rho=0.26; 95%CI: 0.06-0.44; p=0.008). The prevalence of right bundle branch block was positively correlated with HLA-B27 positivity. Use of Anti-TNF-α drugs did not interfere with electrocardiographic parameters. Conclusion Patients with spondyloarthritis had lower heart rate, longer QT interval and a higher prevalence of right bundle branch block compared to controls. HLA-B27 positivity was associated with the prevalence of right bundle branch block. Anti-TNF-α drugs had no impact on electrocardiographic findings.
DOI: 10.6084/m9.figshare.7974287
title: Validity and reliability of the Health Literacy Assessment Scale for adherence to drug treatment among diabetics

description: ABSTRACT Objective To prepare an instrument to evaluate health literacy with regard to adherence to drug treatment among diabetics, identify the validity of its content, and estimate its reliability. Methods Pilot study, with the following stages of instrument construction: literature review, content validation, reliability estimation (internal consistency/Cronbach’s alpha and reproducibility/Kappa). Results The validity of content was completed and presented alpha=0.77 and Kappa values ranged from 0.31 to 1.00. Conclusion The instrument was approved regarding content validity, presented acceptable internal consistency and reproducibility. However, when applied, measurement errors it can produce must be considered.
DOI: 10.6084/m9.figshare.7974287.v1
title: Validity and reliability of the Health Literacy Assessment Scale for adherence to drug treatment among diabetics

description: ABSTRACT Objective To prepare an instrument to evaluate health literacy with regard to adherence to drug treatment among diabetics, identify the validity of its content, and estimate its reliability. Methods Pilot study, with the following stages of instrument construction: literature review, content validation, reliability estimation (internal consistency/Cronbach’s alpha and reproducibility/Kappa). Results The validity of content was completed and presented alpha=0.77 and Kappa values ranged from 0.31 to 1.00. Conclusion The instrument was approved regarding content validity, presented acceptable internal consistency and reproducibility. However, when applied, measurement errors it can produce must be considered.
DOI: 10.34808/cejw-fd16
title: Pilonidal cyst - Male, 32 - Tissue image [6080730009647121]

description: This is the histopathological image of SKIN tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format. The detailed information about the patient, sample, and diagnosis are as follows: Patient:Age: 32Clinical description: Pilonidal cyst.Gender: MaleDiagnosis:Classification: ICD-10_10-20Classification code: Chapter XII - Diseases of the skin and subcutaneous tissueDiagnosis: Pilonidal cystResult of the histopathological examination: Pilonidal cyst.Sample:Material: FFPECollecting method: Surgical specimenTopography: SKINOrgan: SKINTissue: Skin, NOSType of staining: positive/HEStaining: Not applicableAntibody: Not applicableTechnology:Equipment: Pannoramic 250 3DHistechLens: 20xOrganization:Source: Medical University Gdańsk
DOI: 10.34808/qy6y-tk76
title: Nonspecific lymphadenitis - Female, 16 - Tissue image [6080730009656751]

description: This is the histopathological image of LYMPH NODES tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format. The detailed information about the patient, sample, and diagnosis are as follows: Patient:Age: 16Clinical description: Gender: FemaleDiagnosis:Classification: ICD-10_10-20Classification code: Chapter IX - Diseases of the circulatory systemDiagnosis: Nonspecific lymphadenitisResult of the histopathological examination: Sample:Material: FFPECollecting method: Surgical specimenTopography: LYMPH NODESOrgan: LYMPH NODESTissue: Submandibular lymph nodeType of staining: positive/HEStaining: Not applicableAntibody: Not applicableTechnology:Equipment: Pannoramic 250 3DHistechLens: 20xOrganization:Source: Medical University Gdańsk
DOI: 10.34808/9gfb-m755
title: Nonspecific lymphadenitis - Female, 16 - Tissue image [6080730009659291]

description: This is the histopathological image of LYMPH NODES tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format. The detailed information about the patient, sample, and diagnosis are as follows: Patient:Age: 16Clinical description: Gender: FemaleDiagnosis:Classification: ICD-10_10-20Classification code: Chapter IX - Diseases of the circulatory systemDiagnosis: Nonspecific lymphadenitisResult of the histopathological examination: Sample:Material: FFPECollecting method: Surgical specimenTopography: LYMPH NODESOrgan: LYMPH NODESTissue: Submandibular lymph nodeType of staining: positive/IHCStaining: Not applicableAntibody: BCL2Technology:Equipment: Pannoramic 250 3DHistechLens: 20xOrganization:Source: Medical University Gdańsk
DOI: 10.34808/px91-ty65
title: OTHER AND UNSPECIFIED MALE GENITAL ORGANS, Spermatic cord - Male, 27 - Tissue image [6080730009644901]

description: This is the histopathological image of OTHER AND UNSPECIFIED MALE GENITAL ORGANS tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format. The detailed information about the patient, sample, and diagnosis are as follows: Patient:Age: 27Clinical description: Tumour of the left testicleGender: MaleDiagnosis:Classification: HealthyClassification code: Diagnosis: Result of the histopathological examination: Surgical margin of the spermatic cord is free from malignancy.Sample:Material: FFPECollecting method: Surgical specimenTopography: MALE GENITAL ORGANSOrgan: OTHER AND UNSPECIFIED MALE GENITAL ORGANSTissue: Spermatic cordType of staining: positive/HEStaining: Not applicableAntibody: Not applicableTechnology:Equipment: Pannoramic 250 3DHistechLens: 20xOrganization:Source: Medical University Gdańsk
DOI: 10.48567/wedz-n953
title: Bonaparte Point Automatic Weather Station, 2004 unmodified ten-minute observational data.
DOI: 10.48567/e20t-bk59
title: Brianna Automatic Weather Station, 2004 unmodified ten-minute observational data.
DOI: 10.34808/wcbe-2027
title: Nonspecific lymphadenitis - Female, 16 - Tissue image [6080730009656961]

description: This is the histopathological image of LYMPH NODES tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format. The detailed information about the patient, sample, and diagnosis are as follows: Patient:Age: 16Clinical description: Gender: FemaleDiagnosis:Classification: ICD-10_10-20Classification code: Chapter IX - Diseases of the circulatory systemDiagnosis: Nonspecific lymphadenitisResult of the histopathological examination: Sample:Material: FFPECollecting method: Surgical specimenTopography: LYMPH NODESOrgan: LYMPH NODESTissue: Submandibular lymph nodeType of staining: positive/IHCStaining: Not applicableAntibody: MyeloperoxidaseTechnology:Equipment: Pannoramic 250 3DHistechLens: 20xOrganization:Source: Medical University Gdańsk
DOI: 10.34808/x0gc-br04
title: Malignant neoplasm of testis - Male, 27 - Tissue image [6080730009648821]

description: This is the histopathological image of TESTIS tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format. The detailed information about the patient, sample, and diagnosis are as follows: Patient:Age: 27Clinical description: Tumour of the left testicleGender: MaleDiagnosis:Classification: ICD-10_10-20Classification code: Chapter II - NeoplasmsDiagnosis: Malignant neoplasm of testisResult of the histopathological examination: Mixed testicular germ cell tumor, which includes seminoma, germ cell carcinoma and yolk sac tumor. Diffuse intratubular germ cell neoplasia in the adjacent parenchyma. Seminoma  accounts for approximately 60% of malignant uterus, 35% of germ cell carcinoma and 5% of yolk sac tumour. Germ cell carcinoma  with areas of extensive necrosis (about 70-80% of its tissue).
The seminoma focally infiltrates the testicle network. The tumor is confined to the testicle parenchyma and does not infiltrate the lining.
Vascular invasion has not been identified.
IHC: seminoma-OCT 3/4 (+), germ cell carcinoma -OCT 3/4 (+), CD 30 (+), beta HCG (-), Glipican 3 (-), AFP (-), yolk sac tumor -AFP (+), Glipican 3 (+).Sample:Material: FFPECollecting method: Surgical specimenTopography: MALE GENITAL ORGANSOrgan: TESTISTissue: Testis, NOSType of staining: positive/IHCStaining: Not applicableAntibody: Alpha-1-FetoproteinTechnology:Equipment: Pannoramic 250 3DHistechLens: 20xOrganization:Source: Medical University Gdańsk
DOI: 10.34808/6re0-0943
title: OTHER AND UNSPECIFIED MALE GENITAL ORGANS, Other specified parts of male genital organs - Male, 27 - Tissue image [6080730009646521]

description: This is the histopathological image of OTHER AND UNSPECIFIED MALE GENITAL ORGANS tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format. The detailed information about the patient, sample, and diagnosis are as follows: Patient:Age: 27Clinical description: Tumour of the left testicleGender: MaleDiagnosis:Classification: HealthyClassification code: Diagnosis: Result of the histopathological examination: Small cysts in the epididymis. No tumour infiltration was found.Sample:Material: FFPECollecting method: Surgical specimenTopography: MALE GENITAL ORGANSOrgan: OTHER AND UNSPECIFIED MALE GENITAL ORGANSTissue: Other specified parts of male genital organsType of staining: positive/HEStaining: Not applicableAntibody: Not applicableTechnology:Equipment: Pannoramic 250 3DHistechLens: 20xOrganization:Source: Medical University Gdańsk
DOI: 10.48567/men7-y966
title: Butler Island Automatic Weather Station, 2004 unmodified ten-minute observational data.
DOI: 10.34808/at1p-8x78
title: Malignant neoplasm of testis - Male, 27 - Tissue image [6080730009641661]

description: This is the histopathological image of TESTIS tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format. The detailed information about the patient, sample, and diagnosis are as follows: Patient:Age: 27Clinical description: Tumour of the left testicleGender: MaleDiagnosis:Classification: ICD-10_10-20Classification code: Chapter II - NeoplasmsDiagnosis: Malignant neoplasm of testisResult of the histopathological examination: Mixed testicular germ cell tumor, which includes seminoma, germ cell carcinoma and yolk sac tumor. Diffuse intratubular germ cell neoplasia in the adjacent parenchyma. Seminoma  accounts for approximately 60% of malignant uterus, 35% of germ cell carcinoma and 5% of yolk sac tumour. Germ cell carcinoma  with areas of extensive necrosis (about 70-80% of its tissue).
The seminoma focally infiltrates the testicle network. The tumor is confined to the testicle parenchyma and does not infiltrate the lining.
Vascular invasion has not been identified.
IHC: seminoma-OCT 3/4 (+), germ cell carcinoma -OCT 3/4 (+), CD 30 (+), beta HCG (-), Glipican 3 (-), AFP (-), yolk sac tumor -AFP (+), Glipican 3 (+).Sample:Material: FFPECollecting method: Surgical specimenTopography: MALE GENITAL ORGANSOrgan: TESTISTissue: Testis, NOSType of staining: positive/HEStaining: Not applicableAntibody: Not applicableTechnology:Equipment: Pannoramic 250 3DHistechLens: 20xOrganization:Source: Medical University Gdańsk
DOI: 10.48567/168x-g305
title: Byrd Automatic Weather Station, 2004 unmodified ten-minute observational data.
DOI: 10.48567/m94a-2f64
title: Cape Bird Automatic Weather Station, 2004 unmodified ten-minute observational data.
DOI: 10.34808/y004-ch76
title: Polyp of colon - Male, 78 - Tissue image [608073000964331]

description: This is the histopathological image of COLON tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format. The detailed information about the patient, sample, and diagnosis are as follows: Patient:Age: 78Clinical description: Sigmoid diverticula.Gender: MaleDiagnosis:Classification: ICD-10_10-20Classification code: Chapter XI - Diseases of the digestive systemDiagnosis: Polyp of colonResult of the histopathological examination: Colonic tubulo-villous adenoma with low-grade dysplasia, probably completely removed.Sample:Material: FFPECollecting method: Surgical specimenTopography: DIGESTIVE ORGANSOrgan: COLONTissue: Sigmoid colonType of staining: positive/HEStaining: Not applicableAntibody: Not applicableTechnology:Equipment: Pannoramic 250 3DHistechLens: 20xOrganization:Source: Medical University Gdańsk
DOI: 10.48567/0rsw-3j18
title: Cape Denison Automatic Weather Station, 2004 unmodified ten-minute observational data.
DOI: 10.48567/18rr-6769
title: Cape Spencer Automatic Weather Station, 2004 unmodified ten-minute observational data.
DOI: 10.34808/4k33-c923
title: Malignant neoplasm of testis - Male, 27 - Tissue image [6080730009644701]

description: This is the histopathological image of TESTIS tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format. The detailed information about the patient, sample, and diagnosis are as follows: Patient:Age: 27Clinical description: Tumour of the left testicleGender: MaleDiagnosis:Classification: ICD-10_10-20Classification code: Chapter II - NeoplasmsDiagnosis: Malignant neoplasm of testisResult of the histopathological examination: Mixed testicular germ cell tumor, which includes seminoma, germ cell carcinoma and yolk sac tumor. Diffuse intratubular germ cell neoplasia in the adjacent parenchyma. Seminoma  accounts for approximately 60% of malignant uterus, 35% of germ cell carcinoma and 5% of yolk sac tumour. Germ cell carcinoma  with areas of extensive necrosis (about 70-80% of its tissue).
The seminoma focally infiltrates the testicle network. The tumor is confined to the testicle parenchyma and does not infiltrate the lining.
Vascular invasion has not been identified.
IHC: seminoma-OCT 3/4 (+), germ cell carcinoma -OCT 3/4 (+), CD 30 (+), beta HCG (-), Glipican 3 (-), AFP (-), yolk sac tumor -AFP (+), Glipican 3 (+).Sample:Material: FFPECollecting method: Surgical specimenTopography: MALE GENITAL ORGANSOrgan: TESTISTissue: Testis, NOSType of staining: positive/IHCStaining: Not applicableAntibody: beta - hCGTechnology:Equipment: Pannoramic 250 3DHistechLens: 20xOrganization:Source: Medical University Gdańsk
DOI: 10.34808/c3f8-fb97
title: Nonspecific lymphadenitis - Female, 16 - Tissue image [6080730009656651]

description: This is the histopathological image of LYMPH NODES tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format. The detailed information about the patient, sample, and diagnosis are as follows: Patient:Age: 16Clinical description: Gender: FemaleDiagnosis:Classification: ICD-10_10-20Classification code: Chapter IX - Diseases of the circulatory systemDiagnosis: Nonspecific lymphadenitisResult of the histopathological examination: Sample:Material: FFPECollecting method: Surgical specimenTopography: LYMPH NODESOrgan: LYMPH NODESTissue: Submandibular lymph nodeType of staining: positive/IHCStaining: Not applicableAntibody: CD 10Technology:Equipment: Pannoramic 250 3DHistechLens: 20xOrganization:Source: Medical University Gdańsk
DOI: 10.48567/r6sj-0j66
title: Clean Air Automatic Weather Station, 2004 unmodified ten-minute observational data.