cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.19967679
title: Effect of monoamine oxidase B A644G variant on nicotine dependence and/or schizophrenia risk

description: Abstract Objectives Schizophrenia (Sch) is a severe and chronic mental illness. Smoking prevalence is higher in patients with Sch than general population. We aimed to investigate the effects of MAOB gene A644G variant on nicotine dependence (ND) and Sch+ND risk in Turkish population and to evaluate by bioinformatic analysis. Methods Present study included 161 individuals with ND, 223 patients with Sch+ND, and 96 non-smoker controls. MAOB A644G variant was analyzed using PCR-RFLP method. As the MAOB gene is located on the X chromosome, each gender was analysed separately. Results The total distributions of AA, AG and GG genotypes of MAOB gene A644G were 44.7%, 22.4% and 32.9% in the ND group, 45.3%, 25.1% and 29.6% in the Sch+ND group and, 44.8, 22.9% and 32.3% in non-smoker controls. No significant differences were observed between groups for the MAOB A644G genotype and allele frequencies when female group compared to male group (p &gt; 0.05). Examination of disease associations of SNPs from each miRNA gene region in GWAS databases yielded results for aging, bipolar disorder, autoimmune, and neurological diseases. Discussion Our results indicate that the MAOB gene A644G variant is not associated with ND and/or Sch susceptibility in the Turkish population.
DOI: 10.6084/m9.figshare.19967679.v1
title: Effect of monoamine oxidase B A644G variant on nicotine dependence and/or schizophrenia risk

description: Abstract Objectives Schizophrenia (Sch) is a severe and chronic mental illness. Smoking prevalence is higher in patients with Sch than general population. We aimed to investigate the effects of MAOB gene A644G variant on nicotine dependence (ND) and Sch+ND risk in Turkish population and to evaluate by bioinformatic analysis. Methods Present study included 161 individuals with ND, 223 patients with Sch+ND, and 96 non-smoker controls. MAOB A644G variant was analyzed using PCR-RFLP method. As the MAOB gene is located on the X chromosome, each gender was analysed separately. Results The total distributions of AA, AG and GG genotypes of MAOB gene A644G were 44.7%, 22.4% and 32.9% in the ND group, 45.3%, 25.1% and 29.6% in the Sch+ND group and, 44.8, 22.9% and 32.3% in non-smoker controls. No significant differences were observed between groups for the MAOB A644G genotype and allele frequencies when female group compared to male group (p &gt; 0.05). Examination of disease associations of SNPs from each miRNA gene region in GWAS databases yielded results for aging, bipolar disorder, autoimmune, and neurological diseases. Discussion Our results indicate that the MAOB gene A644G variant is not associated with ND and/or Sch susceptibility in the Turkish population.
DOI: 10.6084/m9.figshare.8259854
title: Screening of social phobia symptoms in a sample of Egyptian university students

description: Abstract Background Public speaking is a main requisite for academic achievement amongst university students. Epidemiological data on social phobia among University students in the Arab World are scarce. Objectives To screen for social phobia symptoms in a representative sample of Egyptian university students, and to highlight some putative risk factors associated with them. Methods Two thousand nine hundred and nineteen Egyptian university students participated in the study. They were screened for social phobia using Brief Social Phobia Scale (BSPS). Students total and subdomain scores on the BSPS were correlated with their demographic and scholastic variables. Results Social phobia symptoms were estimated to be prevalent among (44%) of the study sample. A significant (p &lt; 0.05) negative correlation was found between students’ age and avoidance scores on BSPS and between students’ educational year and their scores on fear, avoidance and physiologic subdomains on the BSPS. Regression analysis pointed out to a number of predictive factors for the higher total BSPS scores such as female gender and being a medical student. Discussion Our study demonstrated a high rate of social phobia symptoms in university students. It also demonstrated a number of significant predictive factors associated with the domains of social phobia such as gender, BMI, scholastic year and faculty type.
DOI: 10.6084/m9.figshare.8259854.v1
title: Screening of social phobia symptoms in a sample of Egyptian university students

description: Abstract Background Public speaking is a main requisite for academic achievement amongst university students. Epidemiological data on social phobia among University students in the Arab World are scarce. Objectives To screen for social phobia symptoms in a representative sample of Egyptian university students, and to highlight some putative risk factors associated with them. Methods Two thousand nine hundred and nineteen Egyptian university students participated in the study. They were screened for social phobia using Brief Social Phobia Scale (BSPS). Students total and subdomain scores on the BSPS were correlated with their demographic and scholastic variables. Results Social phobia symptoms were estimated to be prevalent among (44%) of the study sample. A significant (p &lt; 0.05) negative correlation was found between students’ age and avoidance scores on BSPS and between students’ educational year and their scores on fear, avoidance and physiologic subdomains on the BSPS. Regression analysis pointed out to a number of predictive factors for the higher total BSPS scores such as female gender and being a medical student. Discussion Our study demonstrated a high rate of social phobia symptoms in university students. It also demonstrated a number of significant predictive factors associated with the domains of social phobia such as gender, BMI, scholastic year and faculty type.
DOI: 10.6084/m9.figshare.8259593
title: Sex-differential effects of olanzapine vs. aripiprazole on glucose and lipid metabolism in first-episode schizophrenia

description: Abstract Objective To compare sex difference in metabolic effect of olanzapine versus aripiprazole on schizophrenia. Methods A twelve-week prospective open-label cohort study to compare four subgroups according to first-episode schizophrenia patients’ type of drug usage and sex: female aripiprazole (n = 11), male aripiprazole (n = 11), female olanzapine (n = 10), and male olanzapine (n = 11) for body mass index, fasting serum triglyceride, total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and fasting glucose. Results Aripiprazole may be associated with weight gain in female patients with low-baseline weight. Aripiprazole may have an adverse effect of weight and favorable effects of circulating glucose and lipid on female over male schizophrenia patients. The aripiprazole–induced changes in glucose and lipid may be independent of body fat storage, especially for female schizophrenia patients. Olanzapine may have adverse effects of weight, glucose and lipid profiles on female over male schizophrenic patients. Discussion Our findings fill the gap in knowledge and provide a sex-specific guidance to psychiatrist better tailoring treatment to individual sex-differential characteristics and a key clue to understand the sex-differential mechanism of antipsychotics-induced metabolic dysfunction.
DOI: 10.6084/m9.figshare.8259593.v1
title: Sex-differential effects of olanzapine vs. aripiprazole on glucose and lipid metabolism in first-episode schizophrenia

description: Abstract Objective To compare sex difference in metabolic effect of olanzapine versus aripiprazole on schizophrenia. Methods A twelve-week prospective open-label cohort study to compare four subgroups according to first-episode schizophrenia patients’ type of drug usage and sex: female aripiprazole (n = 11), male aripiprazole (n = 11), female olanzapine (n = 10), and male olanzapine (n = 11) for body mass index, fasting serum triglyceride, total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and fasting glucose. Results Aripiprazole may be associated with weight gain in female patients with low-baseline weight. Aripiprazole may have an adverse effect of weight and favorable effects of circulating glucose and lipid on female over male schizophrenia patients. The aripiprazole–induced changes in glucose and lipid may be independent of body fat storage, especially for female schizophrenia patients. Olanzapine may have adverse effects of weight, glucose and lipid profiles on female over male schizophrenic patients. Discussion Our findings fill the gap in knowledge and provide a sex-specific guidance to psychiatrist better tailoring treatment to individual sex-differential characteristics and a key clue to understand the sex-differential mechanism of antipsychotics-induced metabolic dysfunction.
DOI: 10.6084/m9.figshare.8259251
title: Associations of parental bonding and adolescent internet addiction symptoms with depression and anxiety in parents of adolescents with attention deficit/hyperactivity disorder

description: Abstract Objectives The aim of the present study was to evaluate the associations of parental bonding and adolescents’ Internet addiction symptoms with depression and anxiety in parents of adolescents with attention deficit/hyperactivity disorder (ADHD). Methods Parental depression and anxiety symptoms, parental bonding, and adolescents’ Internet addiction symptoms were assessed in 46 parent-child dyads using the Center for Epidemiological Studies Depression Scale, State-Trait Anxiety Inventory, Parental Bonding Instrument (PBI), and Chen Internet Addiction Scale, respectively. Forward stepwise multiple regression analysis was used to examine the associations of parental bonding and adolescents’ Internet addiction symptoms with parental depression and anxiety. Results Low care/affection on the PBI was significantly associated with parental depression, and overprotection on the PBI and adolescents’ Internet addiction were significantly associated with parental anxiety. Discussion Parental bonding and adolescents’ Internet addiction are related to depression and anxiety in parents of adolescents with ADHD.
DOI: 10.6084/m9.figshare.8259251.v1
title: Associations of parental bonding and adolescent internet addiction symptoms with depression and anxiety in parents of adolescents with attention deficit/hyperactivity disorder

description: Abstract Objectives The aim of the present study was to evaluate the associations of parental bonding and adolescents’ Internet addiction symptoms with depression and anxiety in parents of adolescents with attention deficit/hyperactivity disorder (ADHD). Methods Parental depression and anxiety symptoms, parental bonding, and adolescents’ Internet addiction symptoms were assessed in 46 parent-child dyads using the Center for Epidemiological Studies Depression Scale, State-Trait Anxiety Inventory, Parental Bonding Instrument (PBI), and Chen Internet Addiction Scale, respectively. Forward stepwise multiple regression analysis was used to examine the associations of parental bonding and adolescents’ Internet addiction symptoms with parental depression and anxiety. Results Low care/affection on the PBI was significantly associated with parental depression, and overprotection on the PBI and adolescents’ Internet addiction were significantly associated with parental anxiety. Discussion Parental bonding and adolescents’ Internet addiction are related to depression and anxiety in parents of adolescents with ADHD.
DOI: 10.6084/m9.figshare.8259296
title: Social norms regarding alcohol use and associated factors among university students in Turkey

description: Abstract Background Misperceptions on the higher rates of peer alcohol use are predictive of increased personal use among university students. Objectives This study aims to assess the prevalence, perceived peers’ social norms and other predictors of alcohol use in a sample of Turkish university students. Methods This study is established upon the baseline Turkish data on alcohol use of the project Social Norms Intervention for the prevention of Polydrug usE (SNIPE). The data was obtained by a self-reported, online questionnaire from 858 students of Marmara University who were registered to the study web page. Results Alcohol use and drunkenness rates were 62.6%, and 40.9%, respectively. Twenty point two percent of students reported drinking alcohol at least once a week in the last two months. Majority of students (70.4%) reported that religion has an important or very important role in their lives. Perceived higher frequency of peer alcohol use (p&lt;0.000) and drunkenness (p&lt;0.000) were significantly associated with personal alcohol use frequency. Tobacco use rate was 60.2% and positively associated with alcohol use frequency (p&lt;0.000). In all participants, male gender (OR: 1.56; 95% CI: 1.07-2.28), giving less importance to religion (OR: 20.91; 95% CI: 10.95-39.95), tobacco use everyday/almost everyday (OR: 17.88; 95% CI: 9.33-34.29), perceived positive peer attitude towards alcohol use (OR: 2.192; 95% CI: 1.25-3.82) and perceived higher frequency of peer alcohol use (OR: 3.487; 95% CI: 1.66-7.31) were found to be associated risk factors for alcohol use. Age (OR: 1.186, CI 95%: 1.03-1.36) and perceived positive peer attitude towards alcohol use (OR: 3.86, CI 95%: 1.84-8.09) were the additional risk factors among female student whereas perceived positive peer alcohol use frequency (OR: 8.08, CI 95%: 2.40-27.10) among male students. Discussion As the first study conducted in Turkey applying social norms theory, our results indicate the noticeable misperceptions of students regarding their peers’ alcohol use. Based on our results, targeting both tobacco and alcohol use, and a gender-sensitive approach employing social norms interventions may enhance the preventive strategies for risky alcohol use among university students.
DOI: 10.6084/m9.figshare.8259296.v1
title: Social norms regarding alcohol use and associated factors among university students in Turkey

description: Abstract Background Misperceptions on the higher rates of peer alcohol use are predictive of increased personal use among university students. Objectives This study aims to assess the prevalence, perceived peers’ social norms and other predictors of alcohol use in a sample of Turkish university students. Methods This study is established upon the baseline Turkish data on alcohol use of the project Social Norms Intervention for the prevention of Polydrug usE (SNIPE). The data was obtained by a self-reported, online questionnaire from 858 students of Marmara University who were registered to the study web page. Results Alcohol use and drunkenness rates were 62.6%, and 40.9%, respectively. Twenty point two percent of students reported drinking alcohol at least once a week in the last two months. Majority of students (70.4%) reported that religion has an important or very important role in their lives. Perceived higher frequency of peer alcohol use (p&lt;0.000) and drunkenness (p&lt;0.000) were significantly associated with personal alcohol use frequency. Tobacco use rate was 60.2% and positively associated with alcohol use frequency (p&lt;0.000). In all participants, male gender (OR: 1.56; 95% CI: 1.07-2.28), giving less importance to religion (OR: 20.91; 95% CI: 10.95-39.95), tobacco use everyday/almost everyday (OR: 17.88; 95% CI: 9.33-34.29), perceived positive peer attitude towards alcohol use (OR: 2.192; 95% CI: 1.25-3.82) and perceived higher frequency of peer alcohol use (OR: 3.487; 95% CI: 1.66-7.31) were found to be associated risk factors for alcohol use. Age (OR: 1.186, CI 95%: 1.03-1.36) and perceived positive peer attitude towards alcohol use (OR: 3.86, CI 95%: 1.84-8.09) were the additional risk factors among female student whereas perceived positive peer alcohol use frequency (OR: 8.08, CI 95%: 2.40-27.10) among male students. Discussion As the first study conducted in Turkey applying social norms theory, our results indicate the noticeable misperceptions of students regarding their peers’ alcohol use. Based on our results, targeting both tobacco and alcohol use, and a gender-sensitive approach employing social norms interventions may enhance the preventive strategies for risky alcohol use among university students.
DOI: 10.6084/m9.figshare.19967680
title: Personality beliefs as a predictor of smartphone addiction

description: Objective The purpose of this study is to determine the relation between smart phone addiction and personality beliefs of university students. Methods A total of 1007 students, 637 females (63.3%) and 370 males (36.7%) participated in the study. “Smart phone addiction scale short form” was used to measure smart phone addiction and “personality beliefs scale” was used to identify personality beliefs. Results According to the performed multiple regression analysis, it was found out that dependent, antisocial, narcissist, histrionic, borderline, paranoid personality, schizoid personality, obsessive compulsive personality, passive-aggressive personality and avoidant personality beliefs predicted smart phone addiction at significant level (R = 0.38, R2 = 0.15, p &lt; 0.001). The mentioned variables explain 15% of the variance. An examination of the t-test shows that dependent personality (t = 5.585, p &lt; 0.001), passive-aggressive personality (t = -4.485, p &lt; .001) and paranoid personality (t = 2.901, p &lt; .01) belief among the mentioned variables are a significant predictor of smart phone addiction. Discussion The obtained results show that dependent, passive-aggressive and paranoid personality beliefs are a significant predictor of smart phone addiction. Research findings are discussed in the light of relevant literature.
DOI: 10.6084/m9.figshare.19967680.v1
title: Personality beliefs as a predictor of smartphone addiction

description: Objective The purpose of this study is to determine the relation between smart phone addiction and personality beliefs of university students. Methods A total of 1007 students, 637 females (63.3%) and 370 males (36.7%) participated in the study. “Smart phone addiction scale short form” was used to measure smart phone addiction and “personality beliefs scale” was used to identify personality beliefs. Results According to the performed multiple regression analysis, it was found out that dependent, antisocial, narcissist, histrionic, borderline, paranoid personality, schizoid personality, obsessive compulsive personality, passive-aggressive personality and avoidant personality beliefs predicted smart phone addiction at significant level (R = 0.38, R2 = 0.15, p &lt; 0.001). The mentioned variables explain 15% of the variance. An examination of the t-test shows that dependent personality (t = 5.585, p &lt; 0.001), passive-aggressive personality (t = -4.485, p &lt; .001) and paranoid personality (t = 2.901, p &lt; .01) belief among the mentioned variables are a significant predictor of smart phone addiction. Discussion The obtained results show that dependent, passive-aggressive and paranoid personality beliefs are a significant predictor of smart phone addiction. Research findings are discussed in the light of relevant literature.
DOI: 10.6084/m9.figshare.19967682
title: Psychological well-being and health perception: predictors for past, present and future

description: Abstract Background Increasing evidence supports an association between psychological well-being and overall health, however, much remains to be understood about this association. The current study addresses this issue by presenting a new perspective focusing on health perceptions. Additionally, it examines the impact of each of six dimensions of psychological well-being on health perception. Methods Data for this study were collected from a sample of 1,155 Portuguese adults in various settings. Findings reveal that psychological well-being dimensions' impact differently on prior, current, and health outlookperceptions. Furthermore, the dimension depressed mood influences current health perception; in turn, current health perception is the strongest predictor for psychological well-being. Our results provide support for a bidirectional relationship between health perception and psychological well-being.
DOI: 10.6084/m9.figshare.19967682.v1
title: Psychological well-being and health perception: predictors for past, present and future

description: Abstract Background Increasing evidence supports an association between psychological well-being and overall health, however, much remains to be understood about this association. The current study addresses this issue by presenting a new perspective focusing on health perceptions. Additionally, it examines the impact of each of six dimensions of psychological well-being on health perception. Methods Data for this study were collected from a sample of 1,155 Portuguese adults in various settings. Findings reveal that psychological well-being dimensions' impact differently on prior, current, and health outlookperceptions. Furthermore, the dimension depressed mood influences current health perception; in turn, current health perception is the strongest predictor for psychological well-being. Our results provide support for a bidirectional relationship between health perception and psychological well-being.
DOI: 10.6084/m9.figshare.19967683
title: Serum level of cathelicidin LL-37 is increased in euthymic patients with bipolar disorder irrespective of their cardio-metabolic status

description: Abstract Background Antimicrobial peptides are components of the innate immune system. Cathelicidin LL-37 plays an important role in antimicrobial defense, exerts proinflammatory effect and strongly affects the immune system functioning. Our recent study revealed that serum concentration of LL-37 is increased in patients with bipolar disorder. Objectives The aim of this study is to re-evaluate serum LL-37 levels in patients with euthymic bipolar disorder and in healthy controls, matched for anthropometric and body composition parameters. Methods 36 adult patients with euthymic bipolar disorder and 68 non-depressed adults were included into the study. Concentration of LL-37 in serum was assessed using ELISA method. Detailed anthropometric measurements, body composition and biochemical analyses were performed. Results There was a statistically significant difference (p = 0.01) in serum LL-37 level between patients with bipolar disorder (4.97 ± 7.98 ng/mL) and control subjects (1.78 ± 2.69 ng/mL). Discussion Results of this study indicate that LL-37 serum level is increased in euthymic bipolar disorder patients. We found that this increase could not be attributed to analyzed anthropometric or body composition parameters.
DOI: 10.6084/m9.figshare.19967683.v1
title: Serum level of cathelicidin LL-37 is increased in euthymic patients with bipolar disorder irrespective of their cardio-metabolic status

description: Abstract Background Antimicrobial peptides are components of the innate immune system. Cathelicidin LL-37 plays an important role in antimicrobial defense, exerts proinflammatory effect and strongly affects the immune system functioning. Our recent study revealed that serum concentration of LL-37 is increased in patients with bipolar disorder. Objectives The aim of this study is to re-evaluate serum LL-37 levels in patients with euthymic bipolar disorder and in healthy controls, matched for anthropometric and body composition parameters. Methods 36 adult patients with euthymic bipolar disorder and 68 non-depressed adults were included into the study. Concentration of LL-37 in serum was assessed using ELISA method. Detailed anthropometric measurements, body composition and biochemical analyses were performed. Results There was a statistically significant difference (p = 0.01) in serum LL-37 level between patients with bipolar disorder (4.97 ± 7.98 ng/mL) and control subjects (1.78 ± 2.69 ng/mL). Discussion Results of this study indicate that LL-37 serum level is increased in euthymic bipolar disorder patients. We found that this increase could not be attributed to analyzed anthropometric or body composition parameters.