cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.5281/zenodo.8189810
title: HeatResilientCity II - work package 2.3: Interactions between buildings and open space adaptation measures – Results of building performance simulations

description: This repository contains the <strong>results of the building performance simulations</strong> carried out in the working package 2.3: Interactions between buildings and open space adaptation measures of the project HeatResilientCity II. The buildings under consideration are a multi-residential so-called „Gründerzeithaus“ (GZH) and a large-panel construction (LPC) building. The results were extracted for two rooms of each building on the top floor/attic and follow a consistent name convention. Each file contains hourly resolved values for the outdoor air temperature, the indoor air temperature, the indoor operative temperature and the relative humidity indoor and outdoor. Further information can be found in the README of this repository. In addition to the “plain” simulation results, some <strong>heat-indicator variables</strong> were calculated and listed in <em>Calculate_Indicators_Dresden.txt </em>and<em> Calculate_Indicators_Erfurt.txt</em>. The calculated quantities include temperature weighted exceedance hours for the limits of 25, 26 and 27 °C, the maximum operative temperature occurring during the simulation and the operative indoor temperature and outdoor air temperatures at 4 am and 6 pm on the last day of the heat period/simulation. The used <strong>input data</strong> and <strong>building models</strong> can be found in the related identifiers.
description: This research was mainly funded by the Federal Ministry of Education and Research (BMBF) in the joint project "HeatResilientCity" (subproject grant number: 01LR2011A und 01LR2011F) and the European Union's Reconstruction and Resilience Facility (ARF) – NextGenerationEU.
DOI: 10.34740/kaggle/dsv/6505580
title: COVID Vaccination in World (updated daily)
DOI: 10.6084/m9.figshare.24042798.v1
title: Supplementary Material for: The Healthy Ageing Questionnaire (HAQ) Index: Validation in the Singapore Longitudinal Ageing Study

description: Objective: Healthy ageing (HA) indices typically use full questionnaire, performance or blood-based assessment of functional ability which are time-consuming and resource-intensive. We developed and validated a simple and brief Healthy Ageing Questionnaire (HAQ) index with comparable measurement accuracy. Study Design and Setting: The 15-item HAQ (scored 0-100) was developed using data of 500 participants in the Singapore Study of Successful Ageing (SSOSA) a sub-cohort of the Singapore Longitudinal Ageing Study (SLAS2). Its construct, concurrent and predictive validity was evaluated in 2161 participants in the SLAS2 who were non-participants of the SSOSA. Results: The HAQ index (mean=64.0, SD=11.8) showed a coherent 3-factor structure (Cronbach’s alpha=0.735). HAQ scores were higher among participants who were female, highly educated, not living alone, non-smoking, non-alcohol drinkers, not at risk of malnutrition, were robust or pre-frail, not disabled, had no or &lt;5 medical conditions, and no recent fall or hospitalization. It was positively correlated with MMSE and life satisfaction, and negatively correlated with age, logMAR vision, 5 times sit-and-stand, and timed-up-and-go. The HAQ index was significantly correlated but showed modest concordance with the Rowe-Kahn SA index. Increasing HAQ index quintiles were associated with increased mortality risks from 40.6 to 9.7 deaths per 1,000 p-y; covariate-adjusted hazard ratio for the highest Q5 levels (HAQ score &gt;70) was 0.44 (95%CI=0.28-0.67). Using ROC analysis of predictive accuracy for survival, the AUC of HAQ was 0.675, and Rowe-Kahn SA index was 0.660 (p=0.361). Conclusion: The HAQ is a brief and accurate HA index that is potentially useful across diverse settings and purposes in research, healthcare and policy-making.
DOI: 10.6084/m9.figshare.24167949
title: CCS values of {Cr<sub>6</sub>} horseshoe clusters for a manuscript in preparation "Self-Association and Dissociation of {Cr<sub>6</sub>}<sub>n</sub> Horseshoe Clusters: Insights from Ion Mobility Mass Spectrometry"

description: CCS values of {Cr<sub>6</sub>} horseshoe clusters for a manuscript in preparation "Self-Association and Dissociation of {Cr<sub>6</sub>}<sub>n</sub> Horseshoe Clusters: Insights from Ion Mobility Mass Spectrometry"
DOI: 10.5517/ccdc.csd.cc2g6xf1
title: CCDC 2270763: Experimental Crystal Structure Determination

description: Related Article: Jose de Jesus Velazquez-Garcia, Krishnayan Basuroy, Darina Storozhuk, Joanne Wong, Serhiy Demeshko, Franc Meyer, Robert Henning, Simone Techert|2023|Dalton Trans.|52|12224|doi:10.1039/D3DT02067C
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5281/zenodo.8363703
title: RBC data

description: RBC data
DOI: 10.5281/zenodo.8363702
title: RBC data

description: RBC data
DOI: 10.6084/m9.figshare.24003954.v1
title: Supplementary Material for: Cognitive impairment is associated with new-onset stroke: evidence from a nationwide prospective cohort study

description: • Background and purpose: Stroke is closely related to cognitive function, and many patients experience cognitive impairment after stroke; however, whether cognitive impairment is associated with an increased risk of stroke remains inconclusive. This study aims to investigate whether cognitive impairment is associated with new-onset stroke (first ever non-fatal stroke) using a national prospective study. Methods: Data from the China Health and Retirement Longitudinal Study (CHARLS) from 2011 to 2018 were used. A total of 11,961 Chinese participants aged &gt;45 years without a history of stroke were included in the present study and divided into a cognitive impairment group and a normal group according to the baseline cognitive score. Logistic regression analysis was used to analyse the association between baseline cognitive function and new-onset stroke. Results: During the 6.96 years follow-up period, 875 participants experienced new-onset stroke. Compared with the cognitively normal group, the odds ratio (95% confidence intervals) for new-onset stroke in the cognitively impaired group was 1.21 (1.04,1.40) when not adjusted for confounders, and 1.22 (1.01, 1.48) after adjusting for established confounding factors, including demographic data, medical history, physical examination, and laboratory indicators. Conclusion: Cognitive impairment was associated with new-onset stroke among middle-aged and elderly Chinese individuals. Further studies should be carried out to confirm the causal relationship between cognitive impairment and stroke.
DOI: 10.34820/fk2/xacwlx/slmpah
title: 18_in_1_1.wav

description: :unav
DOI: 10.34820/fk2/xacwlx/jtcrny
title: 13_syun_1_2.wav

description: :unav
DOI: 10.34820/fk2/xacwlx/ru4ota
title: 13_syun_1_3.wav

description: :unav
DOI: 10.34820/fk2/xacwlx/vvt26e
title: 19_ghun_1_2.wav

description: :unav
DOI: 10.34820/fk2/xacwlx/jouaio
title: 19_ghu_1_3.wav

description: :unav
DOI: 10.34820/fk2/xacwlx/11rew6
title: 10_ru_1_1.wav

description: :unav
DOI: 10.34820/fk2/xacwlx/ssb8ke
title: 19_gho_1_2.wav

description: :unav
DOI: 10.34820/fk2/xacwlx/grshm4
title: 22_ku_1_1.wav

description: :unav
DOI: 10.34820/fk2/xacwlx/etghtx
title: 25_nu_1_1.wav

description: :unav
DOI: 10.34820/fk2/xacwlx/df73eq
title: 17_dzho_1_4.wav

description: :unav
DOI: 10.34820/fk2/xacwlx/lprpxf
title: 21_qu_1_4.wav

description: :unav
DOI: 10.34820/fk2/xacwlx/31g759
title: 5_jin_1_1.wav

description: :unav
DOI: 10.34820/fk2/xacwlx/ubbu3k
title: 12_sin_1_4.wav

description: :unav
DOI: 10.34820/fk2/xacwlx/0zrixo
title: 3_tu_1_2.wav

description: :unav
DOI: 10.34820/fk2/xacwlx/x6gmbz
title: 23_li_1_2.wav

description: :unav
DOI: 10.34820/fk2/xacwlx/qyanzd
title: 14_shu_1_3.wav

description: :unav
DOI: 10.34820/fk2/xacwlx/cpvxes
title: 18_a_1_3.wav

description: :unav
DOI: 10.34820/fk2/xacwlx/fkkrvn
title: 11_zi_1_4.wav

description: :unav
DOI: 10.34820/fk2/xacwlx/wsbh1r
title: 25_nan_1_2.wav

description: :unav
DOI: 10.34820/fk2/xacwlx/jzc92e
title: 27_hu_1_2.wav

description: :unav
DOI: 10.34820/fk2/xacwlx/jlyhu8
title: 19_ghu_1_1.wav

description: :unav
DOI: 10.34820/fk2/xacwlx/5di7qv
title: 28_yi_1_1.wav

description: :unav
DOI: 10.34820/fk2/xacwlx/upnlbd
title: 7_qhi_1_2.wav

description: :unav
DOI: 10.34820/fk2/xacwlx/mb61be
title: 13_syun_1_1.wav

description: :unav
DOI: 10.34820/fk2/xacwlx/lzu0gb
title: 24_man_1_1.wav

description: :unav
DOI: 10.34820/fk2/xacwlx/tjuqp5
title: 13_syu_1_1.wav

description: :unav
DOI: 10.34820/fk2/xacwlx/nxz0wm
title: 28_yi_1_2.wav

description: :unav
DOI: 10.34820/fk2/xacwlx/gy23my
title: 14_shi_1_2.wav

description: :unav
DOI: 10.34820/fk2/xacwlx/n6jnkk
title: 11_zi_1_1.wav

description: :unav
DOI: 10.6084/m9.figshare.16577768
title: dia_dat_original.xlsx

description: <i>Dianthus carthusianorum</i> original data<br>
DOI: 10.6084/m9.figshare.16577768.v1
title: dia_dat_original.xlsx

description: <i>Dianthus carthusianorum</i> original data<br>
DOI: 10.34820/fk2/xacwlx/xa0xik
title: 7_qhun_1_1.wav

description: :unav
DOI: 10.34820/fk2/xacwlx/tym1kw
title: 25_nin_1_4.wav

description: :unav
DOI: 10.34820/fk2/xacwlx/pfzyvc
title: 11_zun_1_3.wav

description: :unav
DOI: 10.34820/fk2/xacwlx/tr8kcb
title: 24_mi_1_2.wav

description: :unav
DOI: 10.34820/fk2/xacwlx/h1fde8
title: 25_nun_1_1.wav

description: :unav
DOI: 10.34820/fk2/xacwlx/k1fivz
title: 25_na_1_1.wav

description: :unav
DOI: 10.34820/fk2/xacwlx/petjtp
title: 22_ka_1_2.wav

description: :unav
DOI: 10.34820/fk2/xacwlx/qm8z84
title: 6_qin_1_3.wav

description: :unav
DOI: 10.34820/fk2/xacwlx/sul8u8
title: 28_yun_1_3.wav

description: :unav
DOI: 10.34820/fk2/xacwlx/uovpyt
title: 14_shi_1_4.wav

description: :unav
DOI: 10.34820/fk2/xacwlx/9xekjt
title: 15_dhi_1_1.wav

description: :unav
DOI: 10.34820/fk2/xacwlx/cgbxr1
title: 18_un_1_1.wav

description: :unav
DOI: 10.34820/fk2/xacwlx/8yzwow
title: 2_bu_1_2.wav

description: :unav
DOI: 10.34820/fk2/xacwlx/mjjruh
title: 15_dhu_1_4.wav

description: :unav
DOI: 10.34820/fk2/xacwlx/tijaxi
title: 16_thu_1_2.wav

description: :unav
DOI: 10.34820/fk2/xacwlx/74telg
title: 8_dun_1_1.wav

description: :unav
DOI: 10.34820/fk2/xacwlx/ish5er
title: 22_kan_1_2.wav

description: :unav
DOI: 10.6084/m9.figshare.16577771
title: dia_dat_mean.xlsx

description: <i>Dianthus carthusianorum, mean viable seed per individual per season.</i><br>
DOI: 10.34820/fk2/xacwlx/rkh5iu
title: 17_dzhun_1_4.wav

description: :unav
DOI: 10.34820/fk2/xacwlx/tfwoos
title: 21_qon_1_3.wav

description: :unav
DOI: 10.34820/fk2/xacwlx/be8ppl
title: 11_zu_1_4.wav

description: :unav
DOI: 10.34820/fk2/xacwlx/kwdmsg
title: 8_da_1_4.wav

description: :unav
DOI: 10.34820/fk2/xacwlx/slfudo
title: 18_in_1_4.wav

description: :unav
DOI: 10.34820/fk2/xacwlx/4wgbm0
title: 3_ta_1_4.wav

description: :unav
DOI: 10.34820/fk2/xacwlx/8qbfem
title: 20_fa_1_1.wav

description: :unav
DOI: 10.34820/fk2/xacwlx/cjokhg
title: 24_mun_1_1.wav

description: :unav
DOI: 10.34820/fk2/xacwlx/0rn1m1
title: 21_qi_1_4.wav

description: :unav
DOI: 10.34820/fk2/xacwlx/hqinlw
title: 15_dho_1_2.wav

description: :unav
DOI: 10.6084/m9.figshare.16577774
title: sca_dat_mean.xlsx

description: <i>Scabiosa ochroleuca </i>mean viable seeds per individual per season<br>
DOI: 10.6084/m9.figshare.16577774.v1
title: sca_dat_mean.xlsx

description: <i>Scabiosa ochroleuca </i>mean viable seeds per individual per season<br>
DOI: 10.34820/fk2/xacwlx/3guiqg
title: 11_zu_1_2.wav

description: :unav
DOI: 10.34820/fk2/xacwlx/9ohzpk
title: 28_yin_1_1.wav

description: :unav
DOI: 10.34820/fk2/xacwlx/fa2bkh
title: 22_ka_1_1.wav

description: :unav
DOI: 10.34820/fk2/xacwlx/pa20kk
title: 3_tun_1_1.wav

description: :unav
DOI: 10.34820/fk2/xacwlx/myxdje
title: 17_dzhu_1_1.wav

description: :unav
DOI: 10.34820/fk2/xacwlx/k763q4
title: 2_bi_1_3.wav

description: :unav
DOI: 10.34820/fk2/xacwlx/qd2h2e
title: 5_ju_1_4.wav

description: :unav
DOI: 10.6084/m9.figshare.16577777
title: sca_dat_original.xlsx

description: <i>Scabiosa ochroleuca</i> original data<br>
DOI: 10.6084/m9.figshare.16577777.v1
title: sca_dat_original.xlsx

description: <i>Scabiosa ochroleuca</i> original data<br>
DOI: 10.34820/fk2/xacwlx/wzis7d
title: 15_dho_1_3.wav

description: :unav
DOI: 10.34820/fk2/xacwlx/gyc6y6
title: 23_lin_1_2.wav

description: :unav
DOI: 10.34820/fk2/xacwlx/munefv
title: 13_syin_1_2.wav

description: :unav
DOI: 10.34820/fk2/xacwlx/kyb6mx
title: 4_tsan_1_4.wav

description: :unav
DOI: 10.34820/fk2/xacwlx/uzue4d
title: 11_zin_1_3.wav

description: :unav
DOI: 10.34820/fk2/xacwlx/uc4epb
title: 16_thin_1_4.wav

description: :unav
DOI: 10.34820/fk2/xacwlx/dukodi
title: 1_a_1_2.wav

description: :unav
DOI: 10.34820/fk2/xacwlx/feepl6
title: 12_sa_1_1.wav

description: :unav
DOI: 10.34820/fk2/xacwlx/499tj0
title: 26_wa_1_1.wav

description: :unav
DOI: 10.34820/fk2/xacwlx/8xj2jf
title: 3_tun_1_2.wav

description: :unav
DOI: 10.34820/fk2/xacwlx/joarvp
title: 8_dan_1_2.wav

description: :unav
DOI: 10.34820/fk2/xacwlx/kvhnfm
title: 24_mun_1_4.wav

description: :unav
DOI: 10.34820/fk2/xacwlx/bluzmw
title: 17_dzhon_1_4.wav

description: :unav
DOI: 10.34820/fk2/xacwlx/bz7mv6
title: 10_rin_1_4.wav

description: :unav
DOI: 10.34820/fk2/xacwlx/dlulps
title: 27_hin_1_2.wav

description: :unav
DOI: 10.34820/fk2/xacwlx/p7ft6h
title: 1_u_1_4.wav

description: :unav
DOI: 10.34820/fk2/xacwlx/lvjlv5
title: 9_dzin_1_2.wav

description: :unav
DOI: 10.34820/fk2/xacwlx/e6yx5w
title: 12_sun_1_4.wav

description: :unav
DOI: 10.34820/fk2/xacwlx/rjb7cp
title: 8_da_1_2.wav

description: :unav
DOI: 10.34820/fk2/xacwlx/coepc3
title: 14_shun_1_2.wav

description: :unav
DOI: 10.34820/fk2/xacwlx/wxrqjq
title: 1_a_1_4.wav

description: :unav
DOI: 10.34820/fk2/xacwlx/nitvhj
title: 22_ki_1_2.wav

description: :unav
DOI: 10.34820/fk2/xacwlx/9bj8qy
title: 7_qhu_1_2.wav

description: :unav
DOI: 10.34820/fk2/xacwlx/qtfiux
title: 17_dzhu_1_3.wav

description: :unav
DOI: 10.34820/fk2/xacwlx/0dlxg1
title: 24_min_1_2.wav

description: :unav
DOI: 10.34820/fk2/xacwlx/pluxmz
title: 4_tsan_1_3.wav

description: :unav
DOI: 10.34820/fk2/xacwlx/cv75bs
title: 12_sa_1_2.wav

description: :unav
DOI: 10.34820/fk2/xacwlx/s7p2re
title: 11_zin_1_2.wav

description: :unav
DOI: 10.34820/fk2/xacwlx/vzd412
title: 22_ka_1_3.wav

description: :unav
DOI: 10.34820/fk2/xacwlx/9hp4vv
title: 9_dzin_1_3.wav

description: :unav
DOI: 10.34820/fk2/xacwlx/yjft48
title: 12_su_1_3.wav

description: :unav
DOI: 10.6084/m9.figshare.6392369
title: Pain severity as a predictor of negative affect following a self-guided quit attempt: An ecological momentary assessment study

description: <i>Background</i>: Past work has documented bidirectional associations between pain and cigarette smoking behaviors such that those who smoke evidence greater pain, and those in pain tend to smoke more. However, such work has not focused on the role of pain in relation to negative affect, which plays an important role during cessation attempts. <i>Objective</i>: The current study evaluated pain as a predictor of negative affect as well as level of interference associated with negative affect among individuals undergoing a self-guided quit attempt. <i>Methods</i>: Study variables were assessed via ecological momentary assessment (EMA) during the 2 weeks following a self-guided quit attempt. Participants included 54 daily smokers (33.3% female; <i>M</i><sub>age</sub> = 34.7, <i>SD</i> = 13.9). <i>Results</i>: There were statistically significant within-person associations of pain ratings with negative affect and interference due to negative affect, such that greater pain was associated with higher levels of each dependent variable. Additionally, there was a within-person effect of smoking status (i.e., smoking vs. abstinence, measured via EMA) on negative affect, but not ratings of interference; smoking was associated with greater negative affect. <i>Conclusion</i>: These findings highlight the importance of bodily pain in relation to negative mood following a quit attempt. Clinically, the results suggest a greater focus on the experience of pain during quit attempts may be warranted.
DOI: 10.34820/fk2/xacwlx/gojkhh
title: 24_ma_1_4.wav

description: :unav
DOI: 10.6084/m9.figshare.6392369.v2
title: Pain severity as a predictor of negative affect following a self-guided quit attempt: An ecological momentary assessment study

description: <i>Background</i>: Past work has documented bidirectional associations between pain and cigarette smoking behaviors such that those who smoke evidence greater pain, and those in pain tend to smoke more. However, such work has not focused on the role of pain in relation to negative affect, which plays an important role during cessation attempts. <i>Objective</i>: The current study evaluated pain as a predictor of negative affect as well as level of interference associated with negative affect among individuals undergoing a self-guided quit attempt. <i>Methods</i>: Study variables were assessed via ecological momentary assessment (EMA) during the 2 weeks following a self-guided quit attempt. Participants included 54 daily smokers (33.3% female; <i>M</i><sub>age</sub> = 34.7, <i>SD</i> = 13.9). <i>Results</i>: There were statistically significant within-person associations of pain ratings with negative affect and interference due to negative affect, such that greater pain was associated with higher levels of each dependent variable. Additionally, there was a within-person effect of smoking status (i.e., smoking vs. abstinence, measured via EMA) on negative affect, but not ratings of interference; smoking was associated with greater negative affect. <i>Conclusion</i>: These findings highlight the importance of bodily pain in relation to negative mood following a quit attempt. Clinically, the results suggest a greater focus on the experience of pain during quit attempts may be warranted.
DOI: 10.34820/fk2/xacwlx/wtygvn
title: 13_syi_1_2.wav

description: :unav
DOI: 10.34820/fk2/xacwlx/oxzoeg
title: 14_shi_1_3.wav

description: :unav
DOI: 10.34820/fk2/xacwlx/qu7lvq
title: 20_fin_1_1.wav

description: :unav
DOI: 10.34820/fk2/xacwlx/rqwpzs
title: 27_han_1_2.wav

description: :unav
DOI: 10.34820/fk2/xacwlx/c189ba
title: 27_hu_1_4.wav

description: :unav
DOI: 10.34820/fk2/xacwlx/bicrse
title: 15_dho_1_1.wav

description: :unav
DOI: 10.34820/fk2/xacwlx/joop36
title: 7_qhu_1_4.wav

description: :unav
DOI: 10.34820/fk2/xacwlx/7rnoyb
title: 2_ba_1_4.wav

description: :unav
DOI: 10.34820/fk2/xacwlx/2y2wfj
title: 22_kan_1_1.wav

description: :unav
DOI: 10.6084/m9.figshare.16577624
title: Supplementary Material for: Jak1/Stat3 Activation Alters Phosphate Metabolism Independently of Sex and Extracellular Phosphate Levels

description: <b><i>Introduction:</i></b> Phosphate homeostasis is regulated by a complex network involving the parathyroid hormone (PTH), fibroblast growth factor 23 (FGF23), and calcitriol acting on several organs including the kidney, intestine, bone, and parathyroid gland. Previously, we showed that activation of the Janus kinase 1 (Jak1)-signal transducer and activator of transcription 3 (Stat3) signaling pathway leads to altered mineral metabolism with higher FGF23 levels, lower PTH, and higher calcitriol levels. Here, we investigated if there are sex differences in the role of Jak1/Stat3 signaling pathway on phosphate metabolism and if this pathway is sensitive to extracellular phosphate alterations. <b><i>Methods:</i></b> We used a mouse model (<i>Jak1</i><sup>S645P+/−</sup>) that resembles a constitutive activating mutation of the Jak1/Stat3 signaling pathway in humans and analyzed the impact of sex on mineral metabolism parameters. Furthermore, we challenged <i>Jak1</i><sup>S645P+/−</sup> male and female mice with a high (1.2% w/w) and low (0.1% w/w) phosphate diet and a diet with phosphate with organic origin with lower bioavailability. <b><i>Results:</i></b> Female mice, as male mice, showed higher intact FGF23 levels but no phosphaturia, and higher calcitriol and lower PTH levels in plasma. A phosphate challenge did not alter the effect of Jak1/Stat3 activation on phosphate metabolism for both genders. However, under a low phosphate diet or a diet with lower phosphate availability, the animals showed a tendency to develop hypophosphatemia. Moreover, male and female mice showed similar phosphate metabolism parameters. The only exception was higher PTH levels in male mice than those in females. <b><i>Discussion/Conclusion:</i></b> Sex and extracellular phosphate levels do not affect the impact of Jak1/Stat3 activation on phosphate metabolism.
DOI: 10.34820/fk2/xacwlx/vsveq8
title: 18_i_1_2.wav

description: :unav
DOI: 10.6084/m9.figshare.16577624.v1
title: Supplementary Material for: Jak1/Stat3 Activation Alters Phosphate Metabolism Independently of Sex and Extracellular Phosphate Levels

description: <b><i>Introduction:</i></b> Phosphate homeostasis is regulated by a complex network involving the parathyroid hormone (PTH), fibroblast growth factor 23 (FGF23), and calcitriol acting on several organs including the kidney, intestine, bone, and parathyroid gland. Previously, we showed that activation of the Janus kinase 1 (Jak1)-signal transducer and activator of transcription 3 (Stat3) signaling pathway leads to altered mineral metabolism with higher FGF23 levels, lower PTH, and higher calcitriol levels. Here, we investigated if there are sex differences in the role of Jak1/Stat3 signaling pathway on phosphate metabolism and if this pathway is sensitive to extracellular phosphate alterations. <b><i>Methods:</i></b> We used a mouse model (<i>Jak1</i><sup>S645P+/−</sup>) that resembles a constitutive activating mutation of the Jak1/Stat3 signaling pathway in humans and analyzed the impact of sex on mineral metabolism parameters. Furthermore, we challenged <i>Jak1</i><sup>S645P+/−</sup> male and female mice with a high (1.2% w/w) and low (0.1% w/w) phosphate diet and a diet with phosphate with organic origin with lower bioavailability. <b><i>Results:</i></b> Female mice, as male mice, showed higher intact FGF23 levels but no phosphaturia, and higher calcitriol and lower PTH levels in plasma. A phosphate challenge did not alter the effect of Jak1/Stat3 activation on phosphate metabolism for both genders. However, under a low phosphate diet or a diet with lower phosphate availability, the animals showed a tendency to develop hypophosphatemia. Moreover, male and female mice showed similar phosphate metabolism parameters. The only exception was higher PTH levels in male mice than those in females. <b><i>Discussion/Conclusion:</i></b> Sex and extracellular phosphate levels do not affect the impact of Jak1/Stat3 activation on phosphate metabolism.
DOI: 10.34820/fk2/xacwlx/04mop9
title: 3_tan_1_3.wav

description: :unav
DOI: 10.34820/fk2/xacwlx/08lca6
title: 24_ma_1_3.wav

description: :unav
DOI: 10.34820/fk2/xacwlx/cion2g
title: 24_min_1_4.wav

description: :unav
DOI: 10.34820/fk2/xacwlx/3wjo43
title: 10_ru_1_4.wav

description: :unav
DOI: 10.34820/fk2/xacwlx/spmc0s
title: 7_qhin_1_4.wav

description: :unav
DOI: 10.34820/fk2/xacwlx/kp3w4r
title: 20_fi_1_3.wav

description: :unav
DOI: 10.34820/fk2/xacwlx/r5krjj
title: 8_din_1_4.wav

description: :unav
DOI: 10.34820/fk2/xacwlx/fafjae
title: 17_dzhi_1_2.wav

description: :unav
DOI: 10.34820/fk2/xacwlx/0wikwd
title: 3_ti_1_3.wav

description: :unav
DOI: 10.34820/fk2/xacwlx/q01sbd
title: 24_man_1_4.wav

description: :unav
DOI: 10.34820/fk2/xacwlx/aehwyz
title: 23_lu_1_3.wav

description: :unav
DOI: 10.34820/fk2/xacwlx/yg5rko
title: 20_fun_1_3.wav

description: :unav
DOI: 10.34820/fk2/xacwlx/gfzwro
title: 12_su_1_1.wav

description: :unav
DOI: 10.34820/fk2/xacwlx/g0budo
title: 7_qhin_1_3.wav

description: :unav
DOI: 10.34820/fk2/xacwlx/wn8yic
title: 6_qi_1_4.wav

description: :unav
DOI: 10.34820/fk2/xacwlx/ds8r0a
title: 7_qhu_1_1.wav

description: :unav