cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.1394939.v2
title: Exploring the Challenges and Opportunities of Leveraging EHRs for Data-Driven Clinical Research

description: Electronic health records (EHRs) can facilitate faster and cheaper clinical research investigations. By collecting diagnostic, intervention, and outcomes data at all levels of care and across time, EHRs capture a richer picture of clinical effects, relationships, efficiency, and more. With increased clinical reliance on EHR systems, the question remains of how to best leverage EHR data for research purposes.
DOI: 10.6084/m9.figshare.1394955.v1
title: MAstVs ORF2 aminoacid tree

description: Evolutionary relationship of MAstV5 with representative MAstV genera. The percentage of replicates in which the associated virus clustered together in the bootstrap test (1000 replicates) is shown next to the branches in each tree. The trees are drawn to scale; bars represent the number of substitutions per site. All positions except ambiguous positions were included. GenBank accession numbers are shown on the tree. Evolutionary tree based on the partial nucleotide sequences of the ORF2 of 65 sequences of MAstV5. The samples obtained in the present study are highlighted with a symbol (bold).
DOI: 10.6084/m9.figshare.1409398.v298
title: ABO phenotype protected reproduction as it is based on fucosylations.

description: The molecular biological relationship between human fertility and the formation of the ABO(H) blood group phenotype is evident in the rare (Oh) or <i>Bombay</i> blood type, which, based on the history of his own family, the <i>Darwin/Wedgewood Dynasty</i>, Charles Darwin would have interpreted as resulting from reduced fertility in consanguinities. In its native form, the <i>Bombay</i> type occurs in individuals with an extremely rare genotype (h/h;se/se), in whom the fucosyltransferases FUT1 and FUT2 are not produced due to point mutations. These enzymes, which are encoded on chromosome 19, are epistatically connected with the A and B allelic glycotransferase functions encoded on chromosome 9, and the fucosyl residues provide the functional-structural basis for the formation of any ABO(H) phenotype on the cell surface or in secretions and plasma proteins. Immunoglobulins are also heavily fucosylated, and fucosyl residues appear, via developmental variations in their positions on cell surfaces and on the heavy chains of immunoglobulins, to increase or reduce antibody-mediated cellular cytotoxicity involving physiological anti-self-reactivity; moreover, by regulating the assembly and intracellular signalling of precursor B cell receptors, the core fucosylation of immunoglobulin heavy chains represents a key mechanism in clonal selection. In fact, the seminal plasma of leukospermic infertile men has been reported to exhibit high levels of poorly core-fucosylated IgG. Thus, when antibody-dependent cellular cytotoxicity can be increased 50-fold simply by removing the single fucose residue from the Fc glycan, in <i>Bombay </i>type individuals, the non-somatic glycosylation processes of embryogenic stem cell-to-germ cell transformation are most likely exposed to metabolic competition with multiple glycosidic sites of poorly fucosylated, glycan-depleted immunoglobulins, suggesting to promote anti-self-reactive cellular cytotoxicity in male gamete performance.
DOI: 10.6084/m9.figshare.1394910
title: The Rate Model

description: The Rate Model
DOI: 10.6084/m9.figshare.1394939.v1
title: Exploring the Challenges and Opportunities of Leveraging EMRs for Data-Driven Clinical Research

description: Electronic medical records (EMRs) can facilitate faster and cheaper clinical research investigations. By collecting diagnostic, intervention, and outcomes data at all levels of care and across time, EMRs capture a richer picture of clinical effects, relationships, efficiency, and more. With increased clinical reliance on EMR systems, the question remains of how to best leverage EMR data for research purposes.
DOI: 10.6084/m9.figshare.1394910.v1
title: The Rate Model

description: The Rate Model
DOI: 10.6084/m9.figshare.1409398.v299
title: ABO phenotype protected reproduction as it is based on fucosylations.

description: The molecular biological relationship between human fertility and the formation of the ABO(H) blood group phenotype is evident in the rare (Oh) or <i>Bombay</i> blood type, which, based on the history of his own family, the <i>Darwin/Wedgewood Dynasty</i>, Charles Darwin would have interpreted as resulting from reduced fertility in consanguinities. In its native form, the <i>Bombay</i> type occurs in individuals with an extremely rare genotype (h/h;se/se), in whom the fucosyltransferases FUT1 and FUT2 are not produced due to point mutations. These enzymes, which are encoded on chromosome 19, are epistatically connected with the A and B allelic glycotransferase functions encoded on chromosome 9, and the fucosyl residues provide the functional-structural basis for the formation of any ABO(H) phenotype on the cell surface or in secretions and plasma proteins. Immunoglobulins are also heavily fucosylated, and fucosyl residues appear, via developmental variations in their positions on cell surfaces and on the heavy chains of immunoglobulins, to increase or reduce antibody-mediated cellular cytotoxicity involving physiological anti-self-reactivity; moreover, by regulating the assembly and intracellular signalling of precursor B cell receptors, the core fucosylation of immunoglobulin heavy chains represents a key mechanism in clonal selection. In fact, the seminal plasma of leukospermic infertile men has been reported to exhibit high levels of poorly core-fucosylated IgG. Thus, when antibody-dependent cellular cytotoxicity can be increased 50-fold simply by removing the single fucose residue from the Fc glycan, in <i>Bombay </i>type individuals, the non-somatic glycosylation processes of embryogenic stem cell-to-germ cell transformation are most likely exposed to metabolic competition with multiple glycosidic sites of poorly fucosylated, glycan-depleted immunoglobulins, suggesting to promote anti-self-reactive cellular cytotoxicity in male gamete performance.
DOI: 10.6084/m9.figshare.1394874
title: Modelling Inhibitors of Plasmepsin II

description: In 2014, Malaria is thought to have killed between 360 000 -750 000 people of which most were young children.The cause of Malaria is the parasite genus Plasmodium, which has begun to show considerable resistance to many of the available medicines. Thus it is clear that new drugs need to be discovered with new mechanisms of parasite inhibition. One such thread of research is to inhibit the ability to catabolise the haemoglobin, a process essential to parasite survival. The enzymes in question to be inhibited are a group of proteases called plasmepsins (Plm I, II and IV). Several inhibitors of Plm II have been identified by Esmark et al and using their activity test data a model can be created to try and predict activity based on other characteristics, or descriptors, of the molecule.
DOI: 10.6084/m9.figshare.1409398.v300
title: ABO phenotype protected reproduction as it is based on fucosylations.

description: The molecular biological relationship between human fertility and the formation of the ABO(H) blood group phenotype is evident in the rare (Oh) or <i>Bombay</i> blood type, which, based on the history of his own family, the <i>Darwin/Wedgewood Dynasty</i>, Charles Darwin would have interpreted as resulting from reduced fertility in consanguinities. In its native form, the <i>Bombay</i> type occurs in individuals with an extremely rare genotype (h/h;se/se), in whom the fucosyltransferases FUT1 and FUT2 are not produced due to point mutations. These enzymes, which are encoded on chromosome 19, are epistatically connected with the A and B allelic glycotransferase functions encoded on chromosome 9, and the fucosyl residues provide the functional-structural basis for the formation of any ABO(H) phenotype on the cell surface or in secretions and plasma proteins. Immunoglobulins are also heavily fucosylated, and fucosyl residues appear, via developmental variations in their positions on cell surfaces and on the heavy chains of immunoglobulins, to increase or reduce antibody-mediated cellular cytotoxicity involving physiological anti-self-reactivity; moreover, by regulating the assembly and intracellular signalling of precursor B cell receptors, the core fucosylation of immunoglobulin heavy chains represents a key mechanism in clonal selection. In fact, the seminal plasma of leukospermic infertile men has been reported to exhibit high levels of poorly core-fucosylated IgG. Thus, when antibody-dependent cellular cytotoxicity can be increased 50-fold simply by removing the single fucose residue from the Fc glycan, in <i>Bombay </i>type individuals, the non-somatic glycosylation processes of embryogenic stem cell-to-germ cell transformation are most likely exposed to metabolic competition with multiple glycosidic sites of poorly fucosylated, glycan-depleted immunoglobulins, suggesting to promote anti-self-reactive cellular cytotoxicity in male gamete performance.
DOI: 10.6084/m9.figshare.1394874.v2
title: Modelling Inhibitors of Plasmepsin II

description: In 2014, Malaria is thought to have killed between 360 000 -750 000 people of which most were young children.The cause of Malaria is the parasite genus Plasmodium, which has begun to show considerable resistance to many of the available medicines. Thus it is clear that new drugs need to be discovered with new mechanisms of parasite inhibition. One such thread of research is to inhibit the ability to catabolise the haemoglobin, a process essential to parasite survival. The enzymes in question to be inhibited are a group of proteases called plasmepsins (Plm I, II and IV). Several inhibitors of Plm II have been identified by Esmark et al and using their activity test data a model can be created to try and predict activity based on other characteristics, or descriptors, of the molecule.
DOI: 10.6084/m9.figshare.1394874.v1
title: Modelling Inhibitors of Plasmepsin II

description: In 2014, Malaria is thought to have killed between 360 000 -750 000 people of which most were young children.The cause of Malaria is the parasite genus Plasmodium, which has begun to show considerable resistance to many of the available medicines. Thus it is clear that new drugs need to be discovered with new mechanisms of parasite inhibition. One such thread of research is to inhibit the ability to catabolise the haemoglobin, a process essential to parasite survival. The enzymes in question to be inhibited are a group of proteases called plasmepsins (Plm I, II and IV). Several inhibitors of Plm II have been identified by Esmark et al and using their activity test data a model can be created to try and predict activity based on other characteristics, or descriptors, of the molecule.
DOI: 10.6084/m9.figshare.1409398.v301
title: ABO phenotype protected reproduction as it is based on fucosylations.

description: The molecular biological relationship between human fertility and the formation of the ABO(H) blood group phenotype is evident in the rare (Oh) or <i>Bombay</i> blood type, which, based on the history of his own family, the <i>Darwin/Wedgewood Dynasty</i>, Charles Darwin would have interpreted as resulting from reduced fertility in consanguinities. In its native form, the <i>Bombay</i> type occurs in individuals with an extremely rare genotype (h/h;se/se), in whom the fucosyltransferases FUT1 and FUT2 are not produced due to point mutations. These enzymes, which are encoded on chromosome 19, are epistatically connected with the A and B allelic glycotransferase functions encoded on chromosome 9, and the fucosyl residues provide the functional-structural basis for the formation of any ABO(H) phenotype on the cell surface or in secretions and plasma proteins. Immunoglobulins are also heavily fucosylated, and fucosyl residues appear, via developmental variations in their positions on cell surfaces and on the heavy chains of immunoglobulins, to increase or reduce antibody-mediated cellular cytotoxicity involving physiological anti-self-reactivity; moreover, by regulating the assembly and intracellular signalling of precursor B cell receptors, the core fucosylation of immunoglobulin heavy chains represents a key mechanism in clonal selection. In fact, the seminal plasma of leukospermic infertile men has been reported to exhibit high levels of poorly core-fucosylated IgG. Thus, when antibody-dependent cellular cytotoxicity can be increased 50-fold simply by removing the single fucose residue from the Fc glycan, in <i>Bombay </i>type individuals, the non-somatic glycosylation processes of embryogenic stem cell-to-germ cell transformation are most likely exposed to metabolic competition with multiple glycosidic sites of poorly fucosylated, glycan-depleted immunoglobulins, suggesting to promote anti-self-reactive cellular cytotoxicity in male gamete performance.
DOI: 10.6084/m9.figshare.1394866
title: Identification of viruses associated with larvae of the dragonfly <i>Leucorrhinia dubia</i>, and damselfly <i>Coenagrion puella</i> from RNA sequencing data

description: Dragonflies and damselflies are hosts to a variety of parasites and pathogens. However, very few studies have investigated which viruses infect dragonflies and damselflies. Here, based on next generation RNA sequencing of RNA from <i>Leucorrhinia dubia</i> (Libellulidae, Anisoptera) and <i>Coenagrion puella</i> (Coenagrionidae, Zygoptera) larvae, data on putative viruses present in odonates are reported. In both species around 20 different putative viruses, often belonging to genera known from other insect species, were found. The annotated genome structure of one novel putative iflavirus in <i>C. puella</i> and new putative iflavirus, dicistrovirus and posa-lika viruses in <i>L. dubia</i> are described<i>.</i> The influence of these viruses on host fitness and their modes of transmission remain to be determined.
DOI: 10.6084/m9.figshare.1394867
title: Temperature response of growth of larval dragonflies – an overview

description: We review the knowledge about the thermal reaction norms of larval growth in Odonata with a focus on the temperature response function. We re-analyze literature data and present our own results on growth rates of larvae of 14 species of Libellulidae reared at different temperatures. Temperature response curves (TRC) were fitted in order to estimate two relevant components of the thermal reaction, namely the optimum temperature for growth (T<sub>opt</sub>) and the increase of growth rate with temperature (Q<sub>10</sub>). We also examined what is known about the thermal minimum (T<sub>min</sub>) and the thermal maximum (T<sub>max</sub>) for growth to delimit the thermal ranges of odonates. All information indicates that larval growth is generally warm adapted, with species-specific variation of T<sub>opt</sub> of 21–31°C, T<sub>min</sub> of 8–12°C, and T<sub>max</sub> of up to 44°C (the latter being the upper lethal limit, the true T<sub>max</sub> for growth remains unknown). The values of Q<sub>10</sub> distinguish some more specialized species, mostly with high T<sub>opt</sub> and of tropical origin, and others being more thermal generalists, often being temperate species and/or from lotic habitats. We examine some biotic and abiotic factors affecting the temperature response of growth and we discuss the temperature response in the light of global warming.
DOI: 10.6084/m9.figshare.1394865
title: A new teiid lizard from the Late Cretaceous of the Haţeg Basin, Romania and its phylogenetic and palaeobiogeographical relationships

description: A new lizard genus and species is described based on a three-dimensionally preserved partial skull and associated lower jaws from the Pui Islaz locality (Late Cretaceous, early Maastrichtian) in the Haţeg Basin, western Romania. <i>Barbatteius vremiri</i> gen. et sp. nov. is diagnosed by a unique combination of symplesiomorphies and synapomorphies. A nested set of synapomorphies support assigning <i>Barbatteius</i> to Teiidae as the first unambiguous Late Cretaceous record of this family from Laurasia. <i>Barbatteius</i> differs from other teiids by having more extensive osteodermal sculpture on the skull roof and suspensorium, and by a pentagonal occipital osteoscute exhibiting more or less parallel lateral margins. <i>Barbatteius</i> is a large-bodied lizard, estimated to be up to 800 mm in total length. It has weakly heterodont dentition, but without enlarged posterior crushing teeth, suggesting that it fed on arthropods, small vertebrates and plants. The mix of taxa with affinities to Euramerica (paramacellodid and borioteiioid lizards) and Gondwana (madtsoiid snakes and the teiid <i>Barbatteius</i>) currently known for the Maastrichtian squamate assemblage from Haţeg Basin supports the growing realization that ‘Haţeg Island’ has a complex palaeobiogeographical history. http://zoobank.org/urn:lsid:zoobank.org:pub:75C2D80F-8DDB-4FB2-9844-1552D626F63D
DOI: 10.6084/m9.figshare.1394866.v1
title: Identification of viruses associated with larvae of the dragonfly <i>Leucorrhinia dubia</i>, and damselfly <i>Coenagrion puella</i> from RNA sequencing data

description: Dragonflies and damselflies are hosts to a variety of parasites and pathogens. However, very few studies have investigated which viruses infect dragonflies and damselflies. Here, based on next generation RNA sequencing of RNA from <i>Leucorrhinia dubia</i> (Libellulidae, Anisoptera) and <i>Coenagrion puella</i> (Coenagrionidae, Zygoptera) larvae, data on putative viruses present in odonates are reported. In both species around 20 different putative viruses, often belonging to genera known from other insect species, were found. The annotated genome structure of one novel putative iflavirus in <i>C. puella</i> and new putative iflavirus, dicistrovirus and posa-lika viruses in <i>L. dubia</i> are described<i>.</i> The influence of these viruses on host fitness and their modes of transmission remain to be determined.
DOI: 10.6084/m9.figshare.1394867.v1
title: Temperature response of growth of larval dragonflies – an overview

description: We review the knowledge about the thermal reaction norms of larval growth in Odonata with a focus on the temperature response function. We re-analyze literature data and present our own results on growth rates of larvae of 14 species of Libellulidae reared at different temperatures. Temperature response curves (TRC) were fitted in order to estimate two relevant components of the thermal reaction, namely the optimum temperature for growth (T<sub>opt</sub>) and the increase of growth rate with temperature (Q<sub>10</sub>). We also examined what is known about the thermal minimum (T<sub>min</sub>) and the thermal maximum (T<sub>max</sub>) for growth to delimit the thermal ranges of odonates. All information indicates that larval growth is generally warm adapted, with species-specific variation of T<sub>opt</sub> of 21–31°C, T<sub>min</sub> of 8–12°C, and T<sub>max</sub> of up to 44°C (the latter being the upper lethal limit, the true T<sub>max</sub> for growth remains unknown). The values of Q<sub>10</sub> distinguish some more specialized species, mostly with high T<sub>opt</sub> and of tropical origin, and others being more thermal generalists, often being temperate species and/or from lotic habitats. We examine some biotic and abiotic factors affecting the temperature response of growth and we discuss the temperature response in the light of global warming.
DOI: 10.6084/m9.figshare.1394865.v1
title: A new teiid lizard from the Late Cretaceous of the Haţeg Basin, Romania and its phylogenetic and palaeobiogeographical relationships

description: A new lizard genus and species is described based on a three-dimensionally preserved partial skull and associated lower jaws from the Pui Islaz locality (Late Cretaceous, early Maastrichtian) in the Haţeg Basin, western Romania. <i>Barbatteius vremiri</i> gen. et sp. nov. is diagnosed by a unique combination of symplesiomorphies and synapomorphies. A nested set of synapomorphies support assigning <i>Barbatteius</i> to Teiidae as the first unambiguous Late Cretaceous record of this family from Laurasia. <i>Barbatteius</i> differs from other teiids by having more extensive osteodermal sculpture on the skull roof and suspensorium, and by a pentagonal occipital osteoscute exhibiting more or less parallel lateral margins. <i>Barbatteius</i> is a large-bodied lizard, estimated to be up to 800 mm in total length. It has weakly heterodont dentition, but without enlarged posterior crushing teeth, suggesting that it fed on arthropods, small vertebrates and plants. The mix of taxa with affinities to Euramerica (paramacellodid and borioteiioid lizards) and Gondwana (madtsoiid snakes and the teiid <i>Barbatteius</i>) currently known for the Maastrichtian squamate assemblage from Haţeg Basin supports the growing realization that ‘Haţeg Island’ has a complex palaeobiogeographical history. http://zoobank.org/urn:lsid:zoobank.org:pub:75C2D80F-8DDB-4FB2-9844-1552D626F63D
DOI: 10.6084/m9.figshare.1409398.v302
title: ABO phenotype protected reproduction as it is based on fucosylations.

description: The molecular biological relationship between human fertility and the formation of the ABO(H) blood group phenotype is evident in the rare (Oh) or <i>Bombay</i> blood type, which, based on the history of his own family, the <i>Darwin/Wedgewood Dynasty</i>, Charles Darwin would have interpreted as resulting from reduced fertility in consanguinities. In its native form, the <i>Bombay</i> type occurs in individuals with an extremely rare genotype (h/h;se/se), in whom the fucosyltransferases FUT1 and FUT2 are not produced due to point mutations. These enzymes, which are encoded on chromosome 19, are epistatically connected with the A and B allelic glycotransferase functions encoded on chromosome 9, and the fucosyl residues provide the functional-structural basis for the formation of any ABO(H) phenotype on the cell surface or in secretions and plasma proteins. Immunoglobulins are also heavily fucosylated, and fucosyl residues appear, via developmental variations in their positions on cell surfaces and on the heavy chains of immunoglobulins, to increase or reduce antibody-mediated cellular cytotoxicity involving physiological anti-self-reactivity; moreover, by regulating the assembly and intracellular signalling of precursor B cell receptors, the core fucosylation of immunoglobulin heavy chains represents a key mechanism in clonal selection. In fact, the seminal plasma of leukospermic infertile men has been reported to exhibit high levels of poorly core-fucosylated IgG. Thus, when antibody-dependent cellular cytotoxicity can be increased 50-fold simply by removing the single fucose residue from the Fc glycan, in <i>Bombay </i>type individuals, the non-somatic glycosylation processes of embryogenic stem cell-to-germ cell transformation are most likely exposed to metabolic competition with multiple glycosidic sites of poorly fucosylated, glycan-depleted immunoglobulins, suggesting to promote anti-self-reactive cellular cytotoxicity in male gamete performance.