cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.8128034
title: MULTI-AGENT BASED MODELING APPLIED TO PORTFOLIO SELECTION IN THE DOOM-LOOP OF SOVEREIGN DEBT CONTEXT*

description: ABSTRACT This study explores the self-fulfilling dynamic between sovereign debt risk and rational choices of neutral, risk-seeking and risk-averse investors, with implications to the systemic risk emergence. The agent-based model parameterization includes investment strategy (randomly selected assets, stock exchange participation, economic segment, and technical analysis), portfolio rebalance period, and stop gain/loss option. We use Brazilian markets data from 2006 to 2017 to simulate stochastic distributions of investments by a set of 3,000 agents in both stages of model verification and validation (robustness check). Using the Capital Asset Pricing Model, we confirmed our proposition that the optimal rational risk attitude (less risk appetite) constitutes a trigger for the self-fulfilling dynamic, having its foundation on government securities yield and in the debt dynamics. This finding is contrary to the equity premium puzzle in the Brazilian case. The findings have implications to policymakers regarding systemic risk issues, among other public policies.
DOI: 10.6084/m9.figshare.8128031
title: Ultrasonographic evaluation of the fetal central nervous system: review of guidelines

description: Abstract Central nervous system malformations constitute the second most common group of anomalies in fetuses. Such malformations have assumed clinical importance because of their association with high rates of perinatal morbidity and mortality. Therefore, it is extremely important to assess the fetal central nervous system during the prenatal period, in order to identify any changes in its development and thereby gain sufficient information to advise parents about pregnancy follow-up, options for fetal therapy, and the timing/type of delivery, as well as the postnatal treatment and prognosis. The objective of this review was to describe the ultrasonographic evaluation of the fetal central nervous system as per the guidelines of the International Society of Ultrasound in Obstetrics and Gynecology.
DOI: 10.6084/m9.figshare.8128034.v1
title: MULTI-AGENT BASED MODELING APPLIED TO PORTFOLIO SELECTION IN THE DOOM-LOOP OF SOVEREIGN DEBT CONTEXT*

description: ABSTRACT This study explores the self-fulfilling dynamic between sovereign debt risk and rational choices of neutral, risk-seeking and risk-averse investors, with implications to the systemic risk emergence. The agent-based model parameterization includes investment strategy (randomly selected assets, stock exchange participation, economic segment, and technical analysis), portfolio rebalance period, and stop gain/loss option. We use Brazilian markets data from 2006 to 2017 to simulate stochastic distributions of investments by a set of 3,000 agents in both stages of model verification and validation (robustness check). Using the Capital Asset Pricing Model, we confirmed our proposition that the optimal rational risk attitude (less risk appetite) constitutes a trigger for the self-fulfilling dynamic, having its foundation on government securities yield and in the debt dynamics. This finding is contrary to the equity premium puzzle in the Brazilian case. The findings have implications to policymakers regarding systemic risk issues, among other public policies.
DOI: 10.6084/m9.figshare.8128031.v1
title: Ultrasonographic evaluation of the fetal central nervous system: review of guidelines

description: Abstract Central nervous system malformations constitute the second most common group of anomalies in fetuses. Such malformations have assumed clinical importance because of their association with high rates of perinatal morbidity and mortality. Therefore, it is extremely important to assess the fetal central nervous system during the prenatal period, in order to identify any changes in its development and thereby gain sufficient information to advise parents about pregnancy follow-up, options for fetal therapy, and the timing/type of delivery, as well as the postnatal treatment and prognosis. The objective of this review was to describe the ultrasonographic evaluation of the fetal central nervous system as per the guidelines of the International Society of Ultrasound in Obstetrics and Gynecology.
DOI: 10.6084/m9.figshare.8128028
title: THE USE OF SIMULATION TO MODEL THE DISPATCH OF INBOUND CONTAINERS IN PORT TERMINALS

description: ABSTRACT This paper describes a study of the dispatch planning/scheduling process for inbound containers handled with a reach stacker. Client container pickup is scheduled at least one day in advance for one of six two-hour time windows (six five-container-high stacks per time window) on a given day. A buffer area is available for the containers to be moved in when clients are being served. The aim of this study was to determine the conditions required to ensure that all the containers are dispatched within the scheduled time window and so meet the clients’ requirements. To this end, the performance indicators were identified and compared using simulations as an analytical tool. The results indicate that the shortest-processing-time (SPT) queueing discipline is preferable to the first-come-first-served (FCFS) discipline and that client arrivals can usefully be restricted to periods shorter than two hours in order to meet container-dispatch and service-quality objectives.
DOI: 10.6084/m9.figshare.8128028.v1
title: THE USE OF SIMULATION TO MODEL THE DISPATCH OF INBOUND CONTAINERS IN PORT TERMINALS

description: ABSTRACT This paper describes a study of the dispatch planning/scheduling process for inbound containers handled with a reach stacker. Client container pickup is scheduled at least one day in advance for one of six two-hour time windows (six five-container-high stacks per time window) on a given day. A buffer area is available for the containers to be moved in when clients are being served. The aim of this study was to determine the conditions required to ensure that all the containers are dispatched within the scheduled time window and so meet the clients’ requirements. To this end, the performance indicators were identified and compared using simulations as an analytical tool. The results indicate that the shortest-processing-time (SPT) queueing discipline is preferable to the first-come-first-served (FCFS) discipline and that client arrivals can usefully be restricted to periods shorter than two hours in order to meet container-dispatch and service-quality objectives.
DOI: 10.6084/m9.figshare.8128025
title: ANALYSIS OF MIXED INTEGER PROGRAMMING FORMULATIONS FOR SINGLE MACHINE SCHEDULING PROBLEMS WITH SEQUENCE DEPENDENT SETUP TIMES AND RELEASE DATES

description: ABSTRACT The scheduling of jobs over a single machine with sequence dependent setups is a classical problem setting that appears in many practical applications in production planning and logistics. In this work, we analyze six mixed-integer formulation paradigms for this classical context considering release dates and two objective functions: the total weighted completion time and the total weighted tardiness. For each paradigm, we present and discuss a MIP formulation, introducing in some cases new constraints to improve performance. A dominance hierarchy in terms of strength of their linear relaxations bounds is developed. We report extensive computational experiments on a variety of instances to capture several aspects of practical situations, allowing a comparison regarding size, linear relaxation and overall performance. Based on the results, discussions and recommendations are made for the considered problems.
DOI: 10.6084/m9.figshare.8128025.v1
title: ANALYSIS OF MIXED INTEGER PROGRAMMING FORMULATIONS FOR SINGLE MACHINE SCHEDULING PROBLEMS WITH SEQUENCE DEPENDENT SETUP TIMES AND RELEASE DATES

description: ABSTRACT The scheduling of jobs over a single machine with sequence dependent setups is a classical problem setting that appears in many practical applications in production planning and logistics. In this work, we analyze six mixed-integer formulation paradigms for this classical context considering release dates and two objective functions: the total weighted completion time and the total weighted tardiness. For each paradigm, we present and discuss a MIP formulation, introducing in some cases new constraints to improve performance. A dominance hierarchy in terms of strength of their linear relaxations bounds is developed. We report extensive computational experiments on a variety of instances to capture several aspects of practical situations, allowing a comparison regarding size, linear relaxation and overall performance. Based on the results, discussions and recommendations are made for the considered problems.
DOI: 10.6084/m9.figshare.8128022
title: STOCHASTIC DISCRETE LOT-SIZING WITH LEAD TIMES FOR FUEL SUPPLY OPTIMIZATION

description: ABSTRACT We address the problem of expected cost minimization of meeting the uncertain fuel demand during a time planning horizon, where supply is provided by selecting discrete shipments with lead times. Due to uncertainty and the passage of time, corrective actions can be taken such as cancellation and postponement on supply of shipments with associated costs and delays. This problem is modeled as a stochastic multi-stage capacitated discrete lot-sizing problem with lead times. Computational experiments were performed on the resolution of various instances of the model for four information structures of uncertainty. The experimental optimal values and stochastic rating measures obtained show the validity and interest of the stochastic model, as well as the benefits that can be obtained with respect to a deterministic variant of the model that considers average demand.
DOI: 10.6084/m9.figshare.8128022.v1
title: STOCHASTIC DISCRETE LOT-SIZING WITH LEAD TIMES FOR FUEL SUPPLY OPTIMIZATION

description: ABSTRACT We address the problem of expected cost minimization of meeting the uncertain fuel demand during a time planning horizon, where supply is provided by selecting discrete shipments with lead times. Due to uncertainty and the passage of time, corrective actions can be taken such as cancellation and postponement on supply of shipments with associated costs and delays. This problem is modeled as a stochastic multi-stage capacitated discrete lot-sizing problem with lead times. Computational experiments were performed on the resolution of various instances of the model for four information structures of uncertainty. The experimental optimal values and stochastic rating measures obtained show the validity and interest of the stochastic model, as well as the benefits that can be obtained with respect to a deterministic variant of the model that considers average demand.
DOI: 10.6084/m9.figshare.8128019
title: Traceability of animal protein byproducts in ruminants by multivariate analysis of isotope ratio mass spectrometry to prevent transmission of prion diseases

description: Abstract Background: Ruminant feed containing animal byproduct proteins (ABPs) is prohibited in many countries due to its risk of transmitting prion diseases (PD). In most cases the entire herd is sacrificed, which causes great harm to the producer countries by preventing their exportation of ruminant derived-products. Methods: We used stable isotope ratio mass spectrometry (IRMS) of carbon (13C/12C) and nitrogen (15N/14N) to trace the animal protein in the blood of 15 buffaloes (Bubalus bubalis) divided into three experimental groups: 1 - received only vegetable protein (VP) during 117 days; 2 - received animal and vegetable protein (AVP); and 3 - received animal and vegetable protein with animal protein subsequently removed (AVPR). Groups 2 and 3 received diets containing 13.7% bovine meat and bone meal (MBM) added to a vegetable diet (from days 21-117 in the AVP group and until day 47 in the AVPR group, when MBM was removed). Results: On the 36th day, differences were detectable in the feeding profile (p &lt;0.01) among the three experimental groups, which remained for a further 49 days (85th day). The AVPR group showed isotopic rate reversibility on the 110th day by presenting values similar to those in the control group (VP) (p&gt; 0.05), indicating that it took 63 days to eliminate MBM in this group. Total atoms exchange (&gt; 95%) of 13C and 15N was observed through incorporation of the diet into the AVP and AVPR groups. Conclusions: IRMS is an accurate and sensitive technique for tracing the feeding profile of ruminants through blood analysis, thus enabling investigation of ABP use.
DOI: 10.6084/m9.figshare.8128016
title: TRACKING OF CARDIORESPIRATORY FITNESS FROM CHILDHOOD TO EARLY ADOLESCENCE: MODERATION EFFECT OF SOMATIC MATURATION

description: ABSTRACT Objective: To evaluate cardiorespiratory fitness’ tracking from childhood to adolescence, as well as to test the moderation role of somatic maturation. Methods: Our sample was composed by 375 children (197 boys), with a baseline age between 7 and 10 years old. The children were followed-up over three years. Body mass and stature were measured as anthropometric indicators and were used to estimate maturity status through Moore’s method. Cardiorespiratory fitness was evaluated through 9-minute running test. Body adiposity was estimated through the subcutaneous skinfold method, with measures of triceps and subscapular skinfolds and used as a covariate. Sample was categorized into tertiles. Thereafter, the Kappa (k) coefficient and Lin’s concordance correlation coefficient (LCCC) tests were adopted to verify stability. Dummy variable in regression was used to test moderation effects. All analyses were conducted in Stata 14.0, adopting p&lt;0.05. Results: Cardiorespiratory fitness presented a moderate to low tracking from childhood to adolescence (k=0.294; LCCC=0.458). Moreover, maturity status significantly moderated the association between cardiorespiratory fitness at childhood and adolescence (regardless of cohort and body adiposity) among boys (β=0.644; p=0.003) and role sample (β=0.184; p=0.020), but not girls (-0.217; p=0.413). Conclusions: Tracking of cardiorespiratory fitness from childhood to adolescence is moderate to low in both sexes. Moreover, maturity status moderated the relationship between cardiorespiratory fitness at baseline and in adolescence. A lower age at peak height velocity was associated to a greater cardiorespiratory fitness.
DOI: 10.6084/m9.figshare.8128019.v1
title: Traceability of animal protein byproducts in ruminants by multivariate analysis of isotope ratio mass spectrometry to prevent transmission of prion diseases

description: Abstract Background: Ruminant feed containing animal byproduct proteins (ABPs) is prohibited in many countries due to its risk of transmitting prion diseases (PD). In most cases the entire herd is sacrificed, which causes great harm to the producer countries by preventing their exportation of ruminant derived-products. Methods: We used stable isotope ratio mass spectrometry (IRMS) of carbon (13C/12C) and nitrogen (15N/14N) to trace the animal protein in the blood of 15 buffaloes (Bubalus bubalis) divided into three experimental groups: 1 - received only vegetable protein (VP) during 117 days; 2 - received animal and vegetable protein (AVP); and 3 - received animal and vegetable protein with animal protein subsequently removed (AVPR). Groups 2 and 3 received diets containing 13.7% bovine meat and bone meal (MBM) added to a vegetable diet (from days 21-117 in the AVP group and until day 47 in the AVPR group, when MBM was removed). Results: On the 36th day, differences were detectable in the feeding profile (p &lt;0.01) among the three experimental groups, which remained for a further 49 days (85th day). The AVPR group showed isotopic rate reversibility on the 110th day by presenting values similar to those in the control group (VP) (p&gt; 0.05), indicating that it took 63 days to eliminate MBM in this group. Total atoms exchange (&gt; 95%) of 13C and 15N was observed through incorporation of the diet into the AVP and AVPR groups. Conclusions: IRMS is an accurate and sensitive technique for tracing the feeding profile of ruminants through blood analysis, thus enabling investigation of ABP use.
DOI: 10.6084/m9.figshare.8128016.v1
title: TRACKING OF CARDIORESPIRATORY FITNESS FROM CHILDHOOD TO EARLY ADOLESCENCE: MODERATION EFFECT OF SOMATIC MATURATION

description: ABSTRACT Objective: To evaluate cardiorespiratory fitness’ tracking from childhood to adolescence, as well as to test the moderation role of somatic maturation. Methods: Our sample was composed by 375 children (197 boys), with a baseline age between 7 and 10 years old. The children were followed-up over three years. Body mass and stature were measured as anthropometric indicators and were used to estimate maturity status through Moore’s method. Cardiorespiratory fitness was evaluated through 9-minute running test. Body adiposity was estimated through the subcutaneous skinfold method, with measures of triceps and subscapular skinfolds and used as a covariate. Sample was categorized into tertiles. Thereafter, the Kappa (k) coefficient and Lin’s concordance correlation coefficient (LCCC) tests were adopted to verify stability. Dummy variable in regression was used to test moderation effects. All analyses were conducted in Stata 14.0, adopting p&lt;0.05. Results: Cardiorespiratory fitness presented a moderate to low tracking from childhood to adolescence (k=0.294; LCCC=0.458). Moreover, maturity status significantly moderated the association between cardiorespiratory fitness at childhood and adolescence (regardless of cohort and body adiposity) among boys (β=0.644; p=0.003) and role sample (β=0.184; p=0.020), but not girls (-0.217; p=0.413). Conclusions: Tracking of cardiorespiratory fitness from childhood to adolescence is moderate to low in both sexes. Moreover, maturity status moderated the relationship between cardiorespiratory fitness at baseline and in adolescence. A lower age at peak height velocity was associated to a greater cardiorespiratory fitness.
DOI: 10.6084/m9.figshare.8128013
title: Sensitivity Analysis of Flexible Rotor Subjected to Interval Uncertainties

description: Abstract This paper aims at analyzing the sensitivity of the structural response of flexible rotors subjected to uncertain interval parameters. The interval approach encompasses both an uncertainty and sensitivity analyses. The uncertainty analysis consists in computing the interval uncertain structural responses by using the global optimization method. The sensitivity analysis computes the normalized relative sensitivity indices that quantify the degree of importance of each uncertain interval parameter on the uncertain structural responses of the flexible rotor. The uncertain structural responses and the sensitivity of the flexible rotor subjected to interval parameters are analyzed in terms of the Frequency Response Function (FRF), orbits, Campbell diagram, and run-up operating condition. Numerical simulation results illustrate the interval approach conveyed.
DOI: 10.6084/m9.figshare.8128013.v1
title: Sensitivity Analysis of Flexible Rotor Subjected to Interval Uncertainties

description: Abstract This paper aims at analyzing the sensitivity of the structural response of flexible rotors subjected to uncertain interval parameters. The interval approach encompasses both an uncertainty and sensitivity analyses. The uncertainty analysis consists in computing the interval uncertain structural responses by using the global optimization method. The sensitivity analysis computes the normalized relative sensitivity indices that quantify the degree of importance of each uncertain interval parameter on the uncertain structural responses of the flexible rotor. The uncertain structural responses and the sensitivity of the flexible rotor subjected to interval parameters are analyzed in terms of the Frequency Response Function (FRF), orbits, Campbell diagram, and run-up operating condition. Numerical simulation results illustrate the interval approach conveyed.
DOI: 10.6084/m9.figshare.8128010
title: NEW THEORETICAL INVESTIGATIONS ON THE GAP OF THE SKIVING STOCK PROBLEM

description: ABSTRACT The one-dimensional skiving stock problem is a combinatorial optimization problem being of high relevance whenever an efficient and sustainable utilization of given resources is intended. In the classical formulation, a given supply of (small) item lengths has to be used to build as many large objects (specified by some target length) as possible. For this ����-hard (discrete) optimization problem, we investigate the quality of the continuous relaxation by considering the additive integrality gap, i.e., the difference between the optimal values of the integer problem and its LP relaxation. In a first step, we derive an improved upper bound for the gap by focusing on the concept of residual instances. Moreover, we show how further upper bounds can be obtained if all problem-specific input data are considered. Additionally, we constructively prove the integer round-down property for two new classes of instances, and introduce several construction principles to obtain gaps greater than or equal to one.
DOI: 10.6084/m9.figshare.8128010.v1
title: NEW THEORETICAL INVESTIGATIONS ON THE GAP OF THE SKIVING STOCK PROBLEM

description: ABSTRACT The one-dimensional skiving stock problem is a combinatorial optimization problem being of high relevance whenever an efficient and sustainable utilization of given resources is intended. In the classical formulation, a given supply of (small) item lengths has to be used to build as many large objects (specified by some target length) as possible. For this ����-hard (discrete) optimization problem, we investigate the quality of the continuous relaxation by considering the additive integrality gap, i.e., the difference between the optimal values of the integer problem and its LP relaxation. In a first step, we derive an improved upper bound for the gap by focusing on the concept of residual instances. Moreover, we show how further upper bounds can be obtained if all problem-specific input data are considered. Additionally, we constructively prove the integer round-down property for two new classes of instances, and introduce several construction principles to obtain gaps greater than or equal to one.
DOI: 10.6084/m9.figshare.8128007
title: Cognitive functions in children with congenital adrenal hyperplasia

description: ABSTRACT Objective There is controversy regarding cognitive function in patients with congenital adrenal hyperplasia (CAH). This study is aimed at the assessment of cognitive functions in children with CAH, and their relation to hydrocortisone (HC) therapy and testosterone levels. Subjects and methods Thirty children with CAH due to 21 hydroxylase deficiency were compared with twenty age- and sex-matched healthy controls. HC daily and cumulative doses were calculated, the socioeconomic standard was assessed, and free testosterone was measured. Cognitive function assessment was performed using the Wechsler Intelligence Scale – Revised for Children and Adults (WISC), the Benton Visual Retention Test, and the Wisconsin Card Sorting Test (WCST). Results The mean age (SD) of patients was 10.22 (3.17) years [11 males (36.7%), 19 females (63.3%)]. Mean (SD) HC dose was 15.78 (4.36) mg/m 2 /day. Mean (SD) cumulative HC dose 44,689. 9 (26,892.02) mg. Patients had significantly lower scores in all domains of the WISC test, performed significantly worse in some components of the Benton Visual Retention Test, as well as in the Wisconsin Card Sorting Test. There was no significant difference in cognitive performance when patients were subdivided according to daily HC dose (&lt; 10, 10 – 15, &gt; 15 mg/m 2 /day). A positive correlation existed between cumulative HC dose and worse results of the Benton test. No correlation existed between free testosterone and any of the three tests. Conclusion Patients with CAH are at risk of some cognitive impairment. Hydrocortisone therapy may be implicated. This study highlights the need to assess cognitive functions in CAH.