cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.18677513
title: The economic burden of overweight and obesity in Saudi Arabia

description: <b>Context</b>: The prevalence of overweight and obesity in Saudi Arabia has been rising. Although the health burden of excess weight is well established, little is known about the economic burden. <b>Aims</b>: To assess the economic burden—both direct medical costs and the value of absenteeism and presenteeism—resulting from overweight and obesity in Saudi Arabia. <b>Settings and Design</b>: The cost of overweight and obesity in Saudi Arabia was estimated from a societal perspective using an epidemiologic approach. <b>Methods and Materials</b>: Data were obtained from previously published studies and secondary databases. <b>Statistical analysis used: </b>Overweight/obesity-attributable costs were calculated for six major noncommunicable diseases; sensitivity analyses were conducted for key model parameters. <b>Results: </b>The impact of overweight and obesity for these diseases is found to directly cost a total of $3.8 billion, equal to 4.3 percent of total health expenditures in Saudi Arabia in 2019. Estimated overweight and obesity–attributable absenteeism and presenteeism costs a total of $15.5 billion, equal to 0.9 percent of GDP in 2019. <b>Conclusions: </b>Even when limited to six diseases and a subset of total indirect costs, results indicate that overweight and obesity are a significant economic burden in Saudi Arabia. Future studies should identify strategies to reduce the health and economic burden resulting from excess weight in Saudi Arabia.
DOI: 10.15161/oar.it/74422
title: CovidStat project data

description: This record contains the daily updated data of the CovidStat project. CovidStat is a project carried out by the CovidStat Working Group at INFN, whose creation was promoted within the Italian National Institute of Nuclear Physics with the aim of making a statistical analysis of the data provided daily by the Civil Protection on the spread of the pandemic in Italy. CovidStat data can interactively be browsed at https://covid19.infn.it.
description: The software to process this Root TTree is in the related identifier. Be sure to use the right corresponding version, based on the data in which Root TTree was generated.
DOI: 10.6084/m9.figshare.16726207.v1
title: STOKES local reflection FITS files

description: Attached tables to the paper "Spectral and polarisation properties of reflected X-ray emission from black-hole accretion discs", Podgorny et al. 2021 (MNRAS).
DOI: 10.20351/29he19970225
title: MAYC-97_ORINOCO Cruise, RV Hespérides

description: MAYC-97_ORINOCO Cruise (29HE19970225) carried out on the Research Vessel Hespérides in 1997.
DOI: 10.5281/zenodo.5877197
title: Optimizing the selection of drug-polymer-water formulations for spray-dried solid dispersions in pharmaceutical manufacturing

description: The files contain 2 MINLP formulations and supplementary material discussed in this publication. The MINLP problems are implemented and solved in GAMS version 36.2.0, using SBB and SCIP, a local and global MINLP solver, respectively.
DOI: 10.5281/zenodo.5637599
title: Optimizing the selection of drug-polymer-water formulations for spray-dried solid dispersions in pharmaceutical manufacturing

description: The files contain 2 MINLP formulations and supplementary material discussed in this publication. The MINLP problems are implemented and solved in GAMS version 36.2.0, using SBB and SCIP, a local and global MINLP solver, respectively.
DOI: 10.6084/m9.figshare.17198300
title: Supplementary Material for: Crizotinib versus Alectinib for the Treatment of ALK-Positive Non-Small Cell Lung Cancer: A Systematic Review and Meta-Analysis

description: Background: Crizotinib and alectinib are the two most commonly used anaplastic lymphoma kinase (ALK) inhibitors for ALK-positive non-small cell lung cancer (NSCLC). We compared their antitumor efficacies and adverse effects based on a pooled analysis of the ALEX, ALESIA and J-ALEX clinical trials. Methods: Seven databases were searched for eligible articles. The primary endpoints included overall survival (OS), progression-free survival (PFS), central nervous system (CNS)-PFS, drug responses and adverse effects (AEs). Results: Seven articles on three randomized controlled clinical trials (ALEX, ALESIA and J-ALEX) that included 697 patients were included. Compared with crizotinib, alectinib exhibited superior efficacy in PFS (HR [hazard ratio]: 0.35, [0.25-0.49], p &lt; 0.00001), OS (HR: 0.66, [0.47-0.92], p = 0.02), CNS-PFS (HR: 0.17, [0.11-0.24], p &lt; 0.00001), duration of response (HR: 0.31, [0.23-0.42], p &lt; 0.00001), objective response rate (ORR) (risk ratio [RR]: 0.87, [0.80-0.94], p = 0.0003), partial response (PR) (RR: 0.88, [0.81-0.96], p = 0.004), and grade 3-5 AEs (RR: 1.43, [1.09-1.87], p = 0.009). Additionally, compared with crizotinib, alectinib exhibited a survival advantage that increased with its prolongation of survival time. The disease control rate, complete response and total AEs were comparable between the two groups. The crizotinib group reported higher rates of constipation, nausea, diarrhea, vomiting, peripheral edema, dysgeusia, visual impairment and levels of alanine aminotransferase and aspartate aminotransferase as well as greater decreases in appetite and neutrophil count. Conclusions: In both antitumor efficacy and safety, alectinib appears to be superior to crizotinib for the treatment of ALK-positive NSCLC.
DOI: 10.1285/i15910725v43pi
title: Copertina
DOI: 10.5281/zenodo.5877314
title: Replication Package for 'Anchoring Code Understandability Evaluations Through Task Descriptions'

description: Replication package for: "Anchoring Code Understandability Evaluations Through Task Descriptions", submission under review. The <em>data</em> folder contains dataset and Rmarkdown analysis script. We recommend loading the script with RStudio. For your convenience, we include a self-contained HTML outputted file. The <em>code snippets</em> folder contains the experimental code snippets and a representation with syntax highlighting in HTML. We have implemented the code in this way in LimeSurvey and think that for replication purposes it may be useful to include the markup in this replication package (see `LimeSurvey` subdirectory).
DOI: 10.5281/zenodo.5876817
title: Replication Package for "Evaluating SZZ Implementations Through a Developer-informed Oracle"

description: This is the replication package for the paper "Evaluating SZZ Implementations Through a Developer-informed Oracle" published in the 43rd International Conference on Software Engineering (ICSE 2021). https://arxiv.org/abs/2102.03300
description: License MIT
DOI: 10.5281/zenodo.5876816
title: Replication Package for "Evaluating SZZ Implementations Through a Developer-informed Oracle"

description: This is the replication package for the paper "Evaluating SZZ Implementations Through a Developer-informed Oracle" published in the 43rd International Conference on Software Engineering (ICSE 2021). https://arxiv.org/abs/2102.03300
description: License MIT
DOI: 10.5283/epub.35102
title: Raw data: Complement components showed a time-dependent local expression pattern in constant and acute white light induced photoreceptor damage

description: Background: Photoreceptor cell death due to extensive light exposure and induced oxidative-stress are associated with retinal degeneration. A correlated dysregulation of the complement system amplifies the damaging effects, but the local and time-dependent progression of this mechanism is not thoroughly understood. Methods: Light-induced photoreceptor damage (LD) was induced in Balb/c mice with white light illumination either for 24 h with 1000 lux (constant model) or 0.5 h with 5000 lux (acute model). Complement protein and mRNA expression levels were compared at 1 d and 3 d post LD for C1s, complement factor B (CFB), mannose binding lectin A (MBL-A), mannose-binding protein-associated serine protease 1 (MASP-1), C3, C4, C9 and complement factor P (CFP) in retina and RPE/choroid. Histological analyses visualized apoptosis, microglia migration, gliosis and deposition of the complement activation marker C3d. Systemic anaphylatoxin serum concentrations were determined using an ELISA. Results: Apoptosis, gliosis and microglia migration into the outer nuclear layer showed similar patterns in both models. Local complement factor expression revealed an early upregulation of complement factor mRNA in the acute and constant light regimen at 1 d post treatment for c1s, cfb, masp-1, c3, c4 and c9 in the RPE/choroid. However, intraretinal complement mRNA expression for c1s, cfb, c3 and c4 was increased at 1 d in the constant and at 3 d in the acute model. A comparable regulation on protein level in the retina following both LD models was observed for C3, which was upregulated at 1 d and correlated with increased C3d staining in the ganglion cell layer and at the RPE. In the RPE/choroid C1s-complex protein detection was increased at 3 d after LD irrespectively of the used light intensities. Conclusions: LD in mouse eyes is correlated with local complement activity. The time-dependent local progression of complement regulation on mRNA and protein levels were comparable in the acute and constant LD model, except for the intraretinal, time-dependent mRNA expression. Knowing the relative time courses of local complement expression and cellular activity can help to elucidate novel therapeutic options in retinal degeneration indicating at which time point of disease complement has to be rebalanced.
DOI: 10.6084/m9.figshare.15142066.v1
title: Immediate stress alters social and object interaction and recognition memory in nearly isogenic rat strains with differing stress reactivity

description: Stress prior to learning and recall is known to affect both processes depending on the learning paradigm, the sex of the animal, and their reactivity to stress. Male and female animals of the inbred Wistar-Kyoto More Immobile (WMI) and Less Immobile (WLI) strains were tested in the modified novel object and spatial recognition paradigm and in the social interaction-recognition paradigm immediately after a 30 min restraint stress. The WMI strain shows enhanced stress reactivity compared to its near isogenic WLI control and thus, represents a genetically stress-susceptible rodent model. Without stress, there were no strain differences in social or object recognition, but there were sex differences in both types of investigation. Immediate stress generally increased object investigation, but decreased social interaction in all groups, except the WMI males, who exhibited increased aggression toward the juveniles. While stress increased plasma corticosterone and decreased testosterone levels in WLI males as expected, it increased testosterone in the aggressive WMI males, despite elevated levels of corticosterone. Stress generally decreased recognition, except the spatial recognition of WMI females, which paradoxically improved after stress. The strain-specific effects of immediate stress indicate that stress unlocks the vulnerability encoded by the stable genetic differences between WLIs and WMIs to result in the observed phenotypes.
DOI: 10.6084/m9.figshare.15015964
title: Methylomic and transcriptomic predictors of one-month exposure to cortisol in healthy individuals

description: Allostatic load (AL) refers to the cumulative “wear and tear” on an organism throughout its lifetime. One of the primary contributing factors to AL is prolonged exposure to stress or its primary catabolic agent cortisol. Chronic exposure to stress or cortisol is associated with numerous diseases, including cardiovascular disease, metabolic disorders, and psychiatric disorders. Therefore, a molecular marker capable of integrating a past history of cortisol exposure would be of great utility for assessing disease risk. To this end, we recruited 87 healthy males and females of European ancestry between 18 and 60 years old, extracted genomic DNA and RNA from leukocytes, and implemented a gene-centric DNA enrichment method coupled with bisulfite sequencing and RNA-Seq of total RNA for the determination of genome-wide methylation and gene transcription, respectively. Sequencing data were analyzed against awakening and bedtime cortisol data to identify differentially methylated regions (DMRs) and CpGs (DMCs) and differentially expressed genes (DEGs). Six candidate DMCs (<i>p</i><sub>unadjusted</sub> &lt; 0.005) and nine DEGs (<i>p</i><sub>unadjusted</sub> &lt; 0.0005) were used to construct a prediction model that could capture past 30+ days of both bedtime and awakening cortisol levels. Utilizing a cross-validation approach, we obtained a regression coefficient of <i>R</i><sup>2</sup> = 0.308 for predicting continuous awakening cortisol and an area under the curve (AUC) = 0.753 for dichotomous (high vs. low tertile) awakening cortisol, and <i>R</i><sup>2</sup> = 0.224 and AUC = 0.723 for continuous and dichotomous bedtime cortisol levels, respectively. To our knowledge, the current study represents the first attempt to identify genome-wide predictors of cortisol exposure that utilizes both methylation and transcription targets. The utility of our approach needs to be replicated in an independent cohort of samples for which similar cortisol metrics are available.
DOI: 10.6084/m9.figshare.15142066
title: Immediate stress alters social and object interaction and recognition memory in nearly isogenic rat strains with differing stress reactivity

description: Stress prior to learning and recall is known to affect both processes depending on the learning paradigm, the sex of the animal, and their reactivity to stress. Male and female animals of the inbred Wistar-Kyoto More Immobile (WMI) and Less Immobile (WLI) strains were tested in the modified novel object and spatial recognition paradigm and in the social interaction-recognition paradigm immediately after a 30 min restraint stress. The WMI strain shows enhanced stress reactivity compared to its near isogenic WLI control and thus, represents a genetically stress-susceptible rodent model. Without stress, there were no strain differences in social or object recognition, but there were sex differences in both types of investigation. Immediate stress generally increased object investigation, but decreased social interaction in all groups, except the WMI males, who exhibited increased aggression toward the juveniles. While stress increased plasma corticosterone and decreased testosterone levels in WLI males as expected, it increased testosterone in the aggressive WMI males, despite elevated levels of corticosterone. Stress generally decreased recognition, except the spatial recognition of WMI females, which paradoxically improved after stress. The strain-specific effects of immediate stress indicate that stress unlocks the vulnerability encoded by the stable genetic differences between WLIs and WMIs to result in the observed phenotypes.
DOI: 10.6084/m9.figshare.15015964.v1
title: Methylomic and transcriptomic predictors of one-month exposure to cortisol in healthy individuals

description: Allostatic load (AL) refers to the cumulative “wear and tear” on an organism throughout its lifetime. One of the primary contributing factors to AL is prolonged exposure to stress or its primary catabolic agent cortisol. Chronic exposure to stress or cortisol is associated with numerous diseases, including cardiovascular disease, metabolic disorders, and psychiatric disorders. Therefore, a molecular marker capable of integrating a past history of cortisol exposure would be of great utility for assessing disease risk. To this end, we recruited 87 healthy males and females of European ancestry between 18 and 60 years old, extracted genomic DNA and RNA from leukocytes, and implemented a gene-centric DNA enrichment method coupled with bisulfite sequencing and RNA-Seq of total RNA for the determination of genome-wide methylation and gene transcription, respectively. Sequencing data were analyzed against awakening and bedtime cortisol data to identify differentially methylated regions (DMRs) and CpGs (DMCs) and differentially expressed genes (DEGs). Six candidate DMCs (<i>p</i><sub>unadjusted</sub> &lt; 0.005) and nine DEGs (<i>p</i><sub>unadjusted</sub> &lt; 0.0005) were used to construct a prediction model that could capture past 30+ days of both bedtime and awakening cortisol levels. Utilizing a cross-validation approach, we obtained a regression coefficient of <i>R</i><sup>2</sup> = 0.308 for predicting continuous awakening cortisol and an area under the curve (AUC) = 0.753 for dichotomous (high vs. low tertile) awakening cortisol, and <i>R</i><sup>2</sup> = 0.224 and AUC = 0.723 for continuous and dichotomous bedtime cortisol levels, respectively. To our knowledge, the current study represents the first attempt to identify genome-wide predictors of cortisol exposure that utilizes both methylation and transcription targets. The utility of our approach needs to be replicated in an independent cohort of samples for which similar cortisol metrics are available.
DOI: 10.6084/m9.figshare.15059349
title: Supplementary table 1 of "Pelle and Tube contribute to the Toll pathway dependent anti-microbial peptide productions in the red flour beetle, Tribolium castanuem (Coleoptera:Tenebrionidae) "

description: Primer sequences for qRT-PCR.
DOI: 10.6084/m9.figshare.15059349.v1
title: Supplementary table 1 of "Pelle and Tube contribute to the Toll pathway dependent anti-microbial peptide productions in the red flour beetle, Tribolium castanuem (Coleoptera:Tenebrionidae) "

description: Primer sequences for qRT-PCR.
DOI: 10.6084/m9.figshare.17134304
title: Supplementary Material for: Radiologic response as a prognostic factor in advanced hepatocellular carcinoma with macroscopic vascular invasion after transarterial chemoembolization and radiotherapy

description: Introduction: We evaluated the radiologic response rate of combined transarterial chemoembolization (TACE) plus radiotherapy (RT) in treatment-naïve patients with liver-confined hepatocellular carcinoma (HCC) with macroscopic vascular invasion (MVI) and analyzed its clinical importance in overall survival (OS) outcomes. Methods: Patients who were treated with TACE plus RT as a first-line treatment for HCC with MVI between January 2010 and December 2015 were retrospectively reviewed. Radiologic response was assessed according to the modified Response Evaluation Criteria in Solid Tumors (mRECIST) at 2- and 4-months after completion of RT. Landmark analysis at 2- and 4-months and time-dependent Cox regression analysis using response as a time-dependent covariate were performed for univariable and multivariable analyses. Results: The 2-month landmark analysis included 427 patients, and the 4-month landmark analysis included 355 patients after excluding patients without imaging studies for response evaluation at 4 months. Radiologic responses were observed in 210 (49.2%) patients at 2 months and 181 (51.8%) at 4 months. In multivariable analyses, radiologic response was identified as an independent prognosticator for OS at 2 months (median OS: responders, 23.1 months vs. non-responders, 8.0 months; hazard ratio [HR], 3.194; P &lt; 0.001) and 4 months (median OS: responders, 26.5 months vs. non-responders, 9.3 months; HR, 4.534; P &lt; 0.001). Conclusion: Radiologic response assessed by mRECIST was a significant prognostic factor for OS in patients with advanced-stage HCC showing MVI treated with combined TACE plus RT.
DOI: 10.6084/m9.figshare.17134304.v1
title: Supplementary Material for: Radiologic response as a prognostic factor in advanced hepatocellular carcinoma with macroscopic vascular invasion after transarterial chemoembolization and radiotherapy

description: Introduction: We evaluated the radiologic response rate of combined transarterial chemoembolization (TACE) plus radiotherapy (RT) in treatment-naïve patients with liver-confined hepatocellular carcinoma (HCC) with macroscopic vascular invasion (MVI) and analyzed its clinical importance in overall survival (OS) outcomes. Methods: Patients who were treated with TACE plus RT as a first-line treatment for HCC with MVI between January 2010 and December 2015 were retrospectively reviewed. Radiologic response was assessed according to the modified Response Evaluation Criteria in Solid Tumors (mRECIST) at 2- and 4-months after completion of RT. Landmark analysis at 2- and 4-months and time-dependent Cox regression analysis using response as a time-dependent covariate were performed for univariable and multivariable analyses. Results: The 2-month landmark analysis included 427 patients, and the 4-month landmark analysis included 355 patients after excluding patients without imaging studies for response evaluation at 4 months. Radiologic responses were observed in 210 (49.2%) patients at 2 months and 181 (51.8%) at 4 months. In multivariable analyses, radiologic response was identified as an independent prognosticator for OS at 2 months (median OS: responders, 23.1 months vs. non-responders, 8.0 months; hazard ratio [HR], 3.194; P &lt; 0.001) and 4 months (median OS: responders, 26.5 months vs. non-responders, 9.3 months; HR, 4.534; P &lt; 0.001). Conclusion: Radiologic response assessed by mRECIST was a significant prognostic factor for OS in patients with advanced-stage HCC showing MVI treated with combined TACE plus RT.
DOI: 10.6084/m9.figshare.17754188
title: Genome-wide microsatellite panel for Salminus brasiliensis

description: Supplementary Table S1 - A broad genomic panel with potentially amplifiable microsatellite loci for Salminus brasiliensis (Cuvier, 1816) is publicly made available.
DOI: 10.6084/m9.figshare.17754188.v1
title: Genome-wide microsatellite panel for Salminus brasiliensis

description: Supplementary Table S1 - A broad genomic panel with potentially amplifiable microsatellite loci for Salminus brasiliensis (Cuvier, 1816) is publicly made available.
DOI: 10.6084/m9.figshare.15059367
title: Supplementary Table 2 of "Pelle and Tube contribute to the Toll pathway dependent anti-microbial peptide productions in the red flour beetle, Tribolium castanuem (Coleoptera:Tenebrionidae) "

description: Primer sequences for synthesizing T7-tagged cDNA.
DOI: 10.6084/m9.figshare.15059367.v1
title: Supplementary Table 2 of "Pelle and Tube contribute to the Toll pathway dependent anti-microbial peptide productions in the red flour beetle, Tribolium castanuem (Coleoptera:Tenebrionidae) "

description: Primer sequences for synthesizing T7-tagged cDNA.
DOI: 10.6084/m9.figshare.18685694
title: PMEN1.aln.gz

description: Whole genome alignment of 11 S. pneumoniae PMEN1 isolates.<br>
DOI: 10.5281/zenodo.5877439
title: Impacts of Carbon Neutrality on carbon emissions, economy and industrial water use in China

description: The sectoral carbon emission, industrial water use, and output simulated by IMED|CGE model under the BaU and CNS scenarios in 2017, 2030, and 2060.
DOI: 10.5281/zenodo.5877438
title: Impacts of Carbon Neutrality on carbon emissions, economy and industrial water use in China

description: The sectoral carbon emission, industrial water use, and output simulated by IMED|CGE model under the BaU and CNS scenarios in 2017, 2030, and 2060.
DOI: 10.6084/m9.figshare.18685697
title: ST239.aln.gz

description: Whole genome alignment of 14 <i>S. aureus</i> ST239 isolates.<br>
DOI: 10.5281/zenodo.5877533
title: Replication package for: The Value of Political Connections: Evidence from China's Anti-Corruption Campaign

description: The replication materials contain this README file, two do-files <br> ("ChinaConnections_Alonso_etal_dofilePREP.do" and "ChinaConnections_Alonso_etal_dofileRESULTS.do"),<br> two excel datasets ("CPI" and "DataPrep_POLITICIANS"), and the Appendix to the paper. <br> In order to run the codes, the user will need additional proprietary data from CSMAR that we cannot share. Alonso, M., Palma, N. and Simon-Yarza, B. (2022). The Value of Political Connections: Evidence from China's Anti-Corruption Campaign. Journal of Institutional Economics, forthcoming