DOI: 10.5281/zenodo.16249929
title: KazumichiOta/elderly-brain-template: Elderly Brain Template v1.0

description: Elderly Brain Template — Supplementary Data Repository

This repository accompanies the manuscript



Developing and Validating an Elderly Brain Template:A Comprehensive Comparison with MNI152 for Age-Specific Neuroimaging Analyses


and provides all supplementary data, masks and metrics required to reproduce the figures and statistics in the paper.

1. Overview



Template construction– 90 OASIS-1 scans (65–84 y)

Template validation– 282 IXI scans (QC-passed; 20–80 y)

Age range addressed– older adults, 65 years and above

Content highlights



Final 1 mm isotropic T1 template

Brain, tissue-class and 7 subcortical masks

CSV tables with Dice and whole-brain metrics (3D-SSIM, CC, MSE)

Convergence log of 20 iterative template-building updates




2. File Contents

| Path | Description | |-----|-------------| | tpl-Elderly_res-01_T1w.nii.gz | 1 mm T1-weighted elderly template (176 × 208 × 176, RAS) | | desc-brain_mask.nii.gz | Intracranial brain mask | | gm_mask.nii.gz / wm_mask.nii.gz / csf_mask.nii.gz | Tissue-class probability masks generated with SynthSeg | | atlas-Subcortex7_dseg.nii.gz | 7 binary masks: amygdala, caudate, hippocampus, pallidum, putamen, thalamus, brainstem | | IXI_region_dice.csv | Dice coefficients for each ROI × template × subject | | IXI_metrics.csv | Whole-brain 3D-SSIM, CC, MSE for each subject | | template_construction_metrics.csv | 20-step convergence metrics (phase, CC, MSE, 3D-SSIM) | | Oasis_Japan_demographics.csv | Age / sex table for the 90 OASIS-1 subjects |

All masks are provided under `masks/`.```textmasks/├─ subcortical/          # 7 binary ROI masks│   ├─ brainstem_mask.nii.gz│   ├─ amygdala_mask.nii.gz│   ├─ caudate_mask.nii.gz│   ├─ hippocampus_mask.nii.gz│   ├─ pallidum_mask.nii.gz│   ├─ putamen_mask.nii.gz│   └─ thalamus_mask.nii.gz└─ tissue/               # tissue-class masks (SynthSeg)    ├─ gm_mask.nii.gz    ├─ wm_mask.nii.gz    └─ csf_mask.nii.gz```

3. Usage



Download the NIfTI template and masks from the release assets or Zenodo (DOI below).

Register your subject images to tpl-Elderly_res-01_T1w.nii.gz using ANTs or your preferred tool.

Compute overlap or similarity metrics by loading the CSV templates or running the supplied scripts (see /scripts).




Age-group note: the Age_Group column in the CSV files (A = 20-29 … F = ≥ 70) is only for visual grouping; all statistical models in the paper treat age as continuous.


4. License

All files are released under Creative Commons Attribution-ShareAlike 4.0 (CC BY-SA 4.0).Because the template derives from IXI (CC BY-SA 3.0) and OASIS-1 (OASIS DUA) MRI data, users must also respect those original licences and DUAs.

5. Citation

If you use this template or any associated data, please cite **both** the article and the dataset:

Ota K (Corresponding author), Nakazato Y., Oyama G.Developing and Validating an Elderly Brain Template:A Comprehensive Comparison with MNI152 for Age-Specific Neuroimaging Analyses.NeuroImage. 2025; 320:121473. https://doi.org/10.1016/j.neuroimage.2025.121473

Dataset (concept DOI; latest): https://doi.org/10.5281/zenodo.16249928

Dataset DOI  https://doi.org/10.5281/zenodo.16249929  (Elderly Brain Template v1.0)

6. Contact

Corresponding authorKazumichi Ota, M.D., Ph.D.Department of Neurology, Saitama Medical UniversityE-mail: kota24@saitama-med.ac.jp

7. Acknowledgements

We acknowledge the open-access IXI and OASIS projects for providing the foundational MRI datasets that enabled this work. No dedicated external funding was received.