cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.5788896.v1
title: <i>Biecheleria tirezensis</i> sp. nov. (Dinophyceae, Suessiales), a new halotolerant dinoflagellate species isolated from the athalassohaline Tirez natural pond in Spain

description: A new euryhaline and eurythermal dinoflagellate species, <i>Biecheleria tirezensis</i> sp. nov., is described based on samples taken from an extreme environment, the athalassohaline and particularly sulphate-rich Tirez natural pond (Spain). This species is able to survive in salinities from almost fresh water up to 56 and over a 5–25°C temperature range. Thus, the ecological characteristics of this isolate differentiate it from other species of the same genus. Its morphology, as examined by light, scanning and transmission electron microscopy, shows that the cells are almost spherical, with several series of amphiesmal vesicles. It also has a single elongate amphiesmal vesicle (EAV) observed by SEM and the eyespot has a type E structure, typical of <i>Biecheleria</i>. Spherical and smooth cysts were observed in old cultures. The pigment composition is typical of a peridinin-containing dinoflagellate. Phylogeny inferred from nuclear rDNA SSU, ITS and LSU sequences showed the isolate belongs to the genus <i>Biecheleria</i>, closest to <i>B. cincta</i> and <i>B. brevisulcata</i>. Modelling and analysis of the secondary structure of its ITS2 region, and that of other species of the same genus and some representatives of the most closely related genera, indicated that the isolate represents a new species clearly separated from but related to <i>B. cincta</i>. The criterion of the presence of Compensatory Base Changes (CBCs) in the secondary structure of the ITS2 region as an indicator of species differentiation confirmed this, supporting the establishment of the Tirez pond isolate as a new species of <i>Biecheleria</i>.
DOI: 10.5281/zenodo.4008690
title: Chilean Subduction Zone rupture scenarios and waveform data

description: Chilean Subduction Zone kinematic rupture scenarios and waveform data for the submitted work <strong>Early warning for great earthquakes from characterization of crustal deformation patterns with deep learning (2020)</strong> by Lin et al.
DOI: 10.6084/m9.figshare.5788863
title: Development and validation of a facial expression database based on the dimensional and categorical model of emotions

description: The present study describes the development and validation of a facial expression database comprising five different horizontal face angles in dynamic and static presentations. The database includes twelve expression types portrayed by eight Japanese models. This database was inspired by the dimensional and categorical model of emotions: surprise, fear, sadness, anger with open mouth, anger with closed mouth, disgust with open mouth, disgust with closed mouth, excitement, happiness, relaxation, sleepiness, and neutral (static only). The expressions were validated using emotion classification and Affect Grid rating tasks [Russell, Weiss, & Mendelsohn, 1989. Affect Grid: A single-item scale of pleasure and arousal. <i>Journal of Personality and Social Psychology</i>, <i>57</i>(3), 493–502]. The results indicate that most of the expressions were recognised as the intended emotions and could systematically represent affective valence and arousal. Furthermore, face angle and facial motion information influenced emotion classification and valence and arousal ratings. Our database will be available online at the following URL. https://www.dh.aist.go.jp/database/face2017/.
DOI: 10.6084/m9.figshare.5788839
title: Supplementary Material for: Smoking and Promoter-Specific Deoxyribonucleic Acid Methylation of the Atrial Natriuretic Peptide Gene: Methylation of Smokers and Non-Smokers Differs Significantly during Withdrawal

description: <b><i>Background:</i></b> Atrial natriuretic peptide (ANP) is well known in psychiatric disorders to modulate hypothalamic-pituitary-adrenal axis activity. Disturbances of ANP have been described in early abstinent alcohol-dependent patients. This is the first longitudinal investigation on cytosine-phosphatidyl-guanine (CpG)-island promoter methylation of the <i>ANP</i> gene in the blood of tobacco-dependent patients. <b><i>Methods:</i></b> In a longitudinal approach, we investigated whether changes in ANP serum levels correlated to CpG methylation of the respective gene promoters on days 1, 7, and 14 of tobacco withdrawal. <b><i>Results</i></b> <b><i>and Conclusion:</i></b> Compared to non-smokers, promoter-related deoxyribonucleic acid methylation of the ANP promoter was significantly elevated on days 7 and 14 of withdrawal in tobacco-dependent patients. Baseline methylation status of the ANP promoter was not significantly different from controls, arguing for an impaired regulation during withdrawal.
DOI: 10.6084/m9.figshare.5788839.v1
title: Supplementary Material for: Smoking and Promoter-Specific Deoxyribonucleic Acid Methylation of the Atrial Natriuretic Peptide Gene: Methylation of Smokers and Non-Smokers Differs Significantly during Withdrawal

description: <b><i>Background:</i></b> Atrial natriuretic peptide (ANP) is well known in psychiatric disorders to modulate hypothalamic-pituitary-adrenal axis activity. Disturbances of ANP have been described in early abstinent alcohol-dependent patients. This is the first longitudinal investigation on cytosine-phosphatidyl-guanine (CpG)-island promoter methylation of the <i>ANP</i> gene in the blood of tobacco-dependent patients. <b><i>Methods:</i></b> In a longitudinal approach, we investigated whether changes in ANP serum levels correlated to CpG methylation of the respective gene promoters on days 1, 7, and 14 of tobacco withdrawal. <b><i>Results</i></b> <b><i>and Conclusion:</i></b> Compared to non-smokers, promoter-related deoxyribonucleic acid methylation of the ANP promoter was significantly elevated on days 7 and 14 of withdrawal in tobacco-dependent patients. Baseline methylation status of the ANP promoter was not significantly different from controls, arguing for an impaired regulation during withdrawal.
DOI: 10.6084/m9.figshare.5788824
title: The systematic review of randomized controlled trials of PCSK9 antibodies challenges their “efficacy breakthrough” and the “lower, the better” theory

description: <b>Background:</b> A Cochrane review with meta-analysis showed controversial results about the efficacy of PCSK9 antibodies in the prevention of cardiovascular diseases. This review gives the opportunity to test the relationship between LDL-C levels and cardiovascular events. <b>Methods:</b> The authors analyzed the relationship between the calculated LDL-C lowering and the risk of all-cause mortality, fatal and non-fatal myocardial infarction, fatal and non-fatal stroke, any adverse event, cardiovascular events and cardiovascular disease mortality. <b>Results:</b> No beneficial relationship was found between LDL-C lowering and cardiovascular events explored by meta-regression; instead, there was a trend toward harm. For any of the other outcomes there was no significant association between LDL-C lowering and risk. Furthermore, the authors calculated the efficacy that would be expected through the LDL-C lowering showed in the meta-analysis, considering widely accepted predictions. These were respected only for stroke, while the observed efficacy on other cardiovascular events was significantly lower than the expected, and no significant result was observed at all for fatal outcomes. A separate meta-analysis of trials recruiting familial hypercholesterolemia patients have showed a tendency to harm for almost all outcomes. <b>Conclusions:</b> The relationship between LDL-C lowering and cardiovascular events has not showed any significant association (and even a tendency toward harm), challenging the “lower the better” theory. A separate meta-analysis of trials recruiting familial hypercholesterolemia patients has showed a tendency to harm for all outcomes with PCSK9 antibodies. Therefore, at the moment, the data available from randomized trials does not clearly support the use of these antibodies.
DOI: 10.6084/m9.figshare.5788824.v2
title: The systematic review of randomized controlled trials of PCSK9 antibodies challenges their “efficacy breakthrough” and the “lower, the better” theory

description: <b>Background:</b> A Cochrane review with meta-analysis showed controversial results about the efficacy of PCSK9 antibodies in the prevention of cardiovascular diseases. This review gives the opportunity to test the relationship between LDL-C levels and cardiovascular events. <b>Methods:</b> The authors analyzed the relationship between the calculated LDL-C lowering and the risk of all-cause mortality, fatal and non-fatal myocardial infarction, fatal and non-fatal stroke, any adverse event, cardiovascular events and cardiovascular disease mortality. <b>Results:</b> No beneficial relationship was found between LDL-C lowering and cardiovascular events explored by meta-regression; instead, there was a trend toward harm. For any of the other outcomes there was no significant association between LDL-C lowering and risk. Furthermore, the authors calculated the efficacy that would be expected through the LDL-C lowering showed in the meta-analysis, considering widely accepted predictions. These were respected only for stroke, while the observed efficacy on other cardiovascular events was significantly lower than the expected, and no significant result was observed at all for fatal outcomes. A separate meta-analysis of trials recruiting familial hypercholesterolemia patients have showed a tendency to harm for almost all outcomes. <b>Conclusions:</b> The relationship between LDL-C lowering and cardiovascular events has not showed any significant association (and even a tendency toward harm), challenging the “lower the better” theory. A separate meta-analysis of trials recruiting familial hypercholesterolemia patients has showed a tendency to harm for all outcomes with PCSK9 antibodies. Therefore, at the moment, the data available from randomized trials does not clearly support the use of these antibodies.
DOI: 10.6084/m9.figshare.5788824.v1
title: The systematic review of randomized controlled trials of PCSK9 antibodies challenges their “efficacy breakthrough” and “the lower, the better” theory

description: A Cochrane review with meta-analysis showed controversial results about the efficacy of PCSK9 antibodies in the prevention of cardiovascular diseases. This review gives the opportunity to test the relation between LDL-C levels and cardiovascular events. The authors analysed the relation between the calculated LDL-C lowering and the risk of all-cause mortality, fatal and non-fatal myocardial infarction, fatal and non-fatal stroke, any adverse event, cardiovascular events and cardiovascular disease mortality. No beneficial relation was found between LDL-C lowering and cardiovascular events explored by meta-regression; instead, there was a trend toward harm. For any of the other outcomes there was no significant association between LDL-C lowering and risk. Furthermore, the authors calculated the efficacy that would be expected through the LDL-C lowering showed in the meta-analysis, considering widely accepted predictions. These were respected only for stroke, while the observed efficacy on other cardiovascular events was significantly lower than the expected, and no significant result was observed at all for fatal outcomes. A separate meta-analysis of trials recruiting familial hypercholesterolemia patients have showed a tendency to harm for almost all outcomes. The relationship between LDL-C lowering and cardiovascular events have not showed any significant association (and even a tendency toward harm), challenging “the lower the better” theory. A separate meta-analysis of trials recruiting familial hypercholesterolemia patients has showed a tendency to harm for all outcomes with PCSK9 antibodies. Therefore, at the moment, the data available from randomized trials do not clearly support the use of these antibodies.
DOI: 10.6084/m9.figshare.5788773
title: Accidental pharmacological poisonings in young children: population-based study in three settings

description: <b>Introduction:</b> Pharmacological poisonings in young children are avoidable. Previous studies report calls to poisons centres, presentations to emergency departments (ED) or hospital admissions. There are limited data assessing concurrent management of poisonings across all three settings. We aimed to describe accidental pharmacological poisonings in young children across our Poisons Information Centre (PIC), EDs and hospitals. <b>Methods:</b> A population-based study in New South Wales, Australia, of PIC calls, ED presentations and hospital admissions for accidental pharmacological poisoning in children aged &lt;5 years, 2007–2013. We examined trends, medicines responsible and subsequent management. Medicines were coded using ICD10-AM diagnosis codes (T36-50). <b>Results:</b> Over 2007–2013, pharmacological poisonings accounted for 67,816 PIC calls, 7739 ED presentations and 2082 admissions. Rates (per 10,000 children) of PIC calls declined from 220 to 178; ED presentations were stable (∼22–24), with a decrease in emergency cases offset by an increase in semi- or non-urgent presentations; hospital admissions declined (8–5). Most PIC calls related to “non-opioid analgesics” (25%), and “topical agents” (18%). Nearly every day, one child aged &lt;5 years was admitted to hospital for poisoning. “Benzodiazepines”, “other and unspecified antidepressants”, “uncategorised antihypertensives”, and “4-aminophenol derivatives” accounted for over one-third of all admissions. Most PIC calls (90%) were advised to stay home, 6% referred to hospital. One-quarter of ED presentations resulted in admission. <b>Conclusions:</b> Poisonings reported to PIC and hospitals declined, however, non-urgent ED presentations increased. Strategies to reduce therapeutic errors and access to medicines, and education campaigns to improve Poisons Centre call rates to prevent unnecessary ED presentations are needed.
DOI: 10.6084/m9.figshare.5788773.v1
title: Accidental pharmacological poisonings in young children: population-based study in three settings

description: <b>Introduction:</b> Pharmacological poisonings in young children are avoidable. Previous studies report calls to poisons centres, presentations to emergency departments (ED) or hospital admissions. There are limited data assessing concurrent management of poisonings across all three settings. We aimed to describe accidental pharmacological poisonings in young children across our Poisons Information Centre (PIC), EDs and hospitals. <b>Methods:</b> A population-based study in New South Wales, Australia, of PIC calls, ED presentations and hospital admissions for accidental pharmacological poisoning in children aged &lt;5 years, 2007–2013. We examined trends, medicines responsible and subsequent management. Medicines were coded using ICD10-AM diagnosis codes (T36-50). <b>Results:</b> Over 2007–2013, pharmacological poisonings accounted for 67,816 PIC calls, 7739 ED presentations and 2082 admissions. Rates (per 10,000 children) of PIC calls declined from 220 to 178; ED presentations were stable (∼22–24), with a decrease in emergency cases offset by an increase in semi- or non-urgent presentations; hospital admissions declined (8–5). Most PIC calls related to “non-opioid analgesics” (25%), and “topical agents” (18%). Nearly every day, one child aged &lt;5 years was admitted to hospital for poisoning. “Benzodiazepines”, “other and unspecified antidepressants”, “uncategorised antihypertensives”, and “4-aminophenol derivatives” accounted for over one-third of all admissions. Most PIC calls (90%) were advised to stay home, 6% referred to hospital. One-quarter of ED presentations resulted in admission. <b>Conclusions:</b> Poisonings reported to PIC and hospitals declined, however, non-urgent ED presentations increased. Strategies to reduce therapeutic errors and access to medicines, and education campaigns to improve Poisons Centre call rates to prevent unnecessary ED presentations are needed.
DOI: 10.6084/m9.figshare.5788746
title: Additional file 4: Table S3. of Global analysis of prokaryotic tRNA-derived cyclodipeptide biosynthesis

description: Complete set of 739 unique cyclodipeptide synthases identified in a global analysis of publicly available prokaryotic genomes. (XLSX 144Â kb)
DOI: 10.6084/m9.figshare.5788746.v1
title: Additional file 4: Table S3. of Global analysis of prokaryotic tRNA-derived cyclodipeptide biosynthesis

description: Complete set of 739 unique cyclodipeptide synthases identified in a global analysis of publicly available prokaryotic genomes. (XLSX 144Â kb)
DOI: 10.6084/m9.figshare.5788740
title: Additional file 2: Table S2. of Global analysis of prokaryotic tRNA-derived cyclodipeptide biosynthesis

description: Active site residues annotated by Jacques et al... and predicted by PRISM. (XLSX 47Â kb)
DOI: 10.6084/m9.figshare.5788740.v1
title: Additional file 2: Table S2. of Global analysis of prokaryotic tRNA-derived cyclodipeptide biosynthesis

description: Active site residues annotated by Jacques et al... and predicted by PRISM. (XLSX 47Â kb)
DOI: 10.6084/m9.figshare.5788737
title: Additional file 1: Table S1. of Global analysis of prokaryotic tRNA-derived cyclodipeptide biosynthesis

description: Hidden Markov models developed for this study, and their bit score cutoffs and associated tailoring reactions. (XLSX 41Â kb)
DOI: 10.6084/m9.figshare.5788737.v1
title: Additional file 1: Table S1. of Global analysis of prokaryotic tRNA-derived cyclodipeptide biosynthesis

description: Hidden Markov models developed for this study, and their bit score cutoffs and associated tailoring reactions. (XLSX 41Â kb)
DOI: 10.6084/m9.figshare.5788683
title: Additional file 6: of Association between sequence variants in panicle development genes and the number of spikelets per panicle in rice

description: Summary of statistics for four traits of 45 varieties. (XLSX 10Â kb)
DOI: 10.6084/m9.figshare.5788683.v1
title: Additional file 6: of Association between sequence variants in panicle development genes and the number of spikelets per panicle in rice

description: Summary of statistics for four traits of 45 varieties. (XLSX 10Â kb)
DOI: 10.6084/m9.figshare.5788659
title: Additional file 4: of Association between sequence variants in panicle development genes and the number of spikelets per panicle in rice

description: FASTA format files containing coding sequences for 9 genes. (ZIP 19Â kb)
DOI: 10.6084/m9.figshare.5788659.v1
title: Additional file 4: of Association between sequence variants in panicle development genes and the number of spikelets per panicle in rice

description: FASTA format files containing coding sequences for 9 genes. (ZIP 19Â kb)
DOI: 10.6084/m9.figshare.5788653
title: Additional file 1 of Tackling the challenges of matching biomedical ontologies

description: Manual evaluation of the HP-MP mappings found through logical definitions Tab-separated text file listing each mapping (URI and label of the source and target classes) and its classification. (TSV 13 kb)
DOI: 10.6084/m9.figshare.5788653.v1
title: Additional file 1 of Tackling the challenges of matching biomedical ontologies

description: Manual evaluation of the HP-MP mappings found through logical definitions Tab-separated text file listing each mapping (URI and label of the source and target classes) and its classification. (TSV 13 kb)
DOI: 10.6084/m9.figshare.5788632
title: Additional file 2: of Association between sequence variants in panicle development genes and the number of spikelets per panicle in rice

description: General information for total accessions used in this study. (XLSX 16Â kb)
DOI: 10.6084/m9.figshare.5788554
title: Additional file 3: of Challenges imposed by minor reference alleles on the identification and reporting of clinical variants from exome data

description: NA12878_MRA.xls. Homozygous minor reference alleles in GIAB NA12878 reference sample. (XLS 395Â kb)
DOI: 10.6084/m9.figshare.5788554.v1
title: Additional file 3: of Challenges imposed by minor reference alleles on the identification and reporting of clinical variants from exome data

description: NA12878_MRA.xls. Homozygous minor reference alleles in GIAB NA12878 reference sample. (XLS 395Â kb)
DOI: 10.6084/m9.figshare.5788530
title: Additional file 2: of Challenges imposed by minor reference alleles on the identification and reporting of clinical variants from exome data

description: ExAC_MRA_vcf.xls. ExAC minor reference alleles aligned to hg19 and hg38 in VCF formatting. The tabular data can be exported as tab separated files with vcf extension for use with standard VCF file viewers. (XLS 7347Â kb)
DOI: 10.6084/m9.figshare.5788530.v1
title: Additional file 2: of Challenges imposed by minor reference alleles on the identification and reporting of clinical variants from exome data

description: ExAC_MRA_vcf.xls. ExAC minor reference alleles aligned to hg19 and hg38 in VCF formatting. The tabular data can be exported as tab separated files with vcf extension for use with standard VCF file viewers. (XLS 7347Â kb)
DOI: 10.6084/m9.figshare.5788518
title: Additional file 1: of Challenges imposed by minor reference alleles on the identification and reporting of clinical variants from exome data

description: ExAC_MRA.xls. Minor reference alleles in ExAC database. (XLS 5024Â kb)
DOI: 10.6084/m9.figshare.5788518.v1
title: Additional file 1: of Challenges imposed by minor reference alleles on the identification and reporting of clinical variants from exome data

description: ExAC_MRA.xls. Minor reference alleles in ExAC database. (XLS 5024Â kb)
DOI: 10.6084/m9.figshare.5788428
title: Additional file 2: of Antisense suppression of the nonsense mediated decay factor Upf3b as a potential treatment for diseases caused by nonsense mutations

description: This file contains four supplementary tables (Tables S1â S4). (XLSX 95 kb)
DOI: 10.6084/m9.figshare.5788428.v1
title: Additional file 2: of Antisense suppression of the nonsense mediated decay factor Upf3b as a potential treatment for diseases caused by nonsense mutations

description: This file contains four supplementary tables (Tables S1â S4). (XLSX 95 kb)
DOI: 10.6084/m9.figshare.5788353
title: Additional file 2 of seq-seq-pan: building a computational pan-genome data structure on whole genome alignment

description: Supplementary Tables for â seq-seq-pan: Building a computational pan-genome data structure on whole genome alignmentâ . Additional fileÂ 2 provides detailed description of the used datasets, including accession numbers and sort order. (XLSX 83 kb)
DOI: 10.6084/m9.figshare.5788353.v1
title: Additional file 2 of seq-seq-pan: building a computational pan-genome data structure on whole genome alignment

description: Supplementary Tables for â seq-seq-pan: Building a computational pan-genome data structure on whole genome alignmentâ . Additional fileÂ 2 provides detailed description of the used datasets, including accession numbers and sort order. (XLSX 83 kb)
DOI: 10.6084/m9.figshare.5788293
title: Additional file 2: Table S1. of Epidermal Wnt signalling regulates transcriptome heterogeneity and proliferative fate in neighbouring cells

description: Related to Fig. 1e. List of marker genes for each keratinocyte cell state (states A–E). Table S2. Related to Fig. 3f. Differentially dispersed genes for states A–E. Table S3. Related to Fig. 4a. Genes dynamically expressed (and statistically significant) along the NCA Wnt-induced cell state transition. Cluster represents the four clusters of gene expression shown in Fig. 4a. Table S4. Related to Fig. 4b-d. List of TFs identified as regulating the NCA Wnt-induced cell state transition. (XLSX 71 kb)