cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.21640100.v1
title: Association Between Lipid Profile and Clinical Manifestations in Sickle Cell Anemia: A Systematic Review

description: Abstract Introduction Sickle cell anemia (SCA) is a genetic disease associated with frequent episodes of acute illness. Changes in the lipid profile and a chronic inflammatory process make up the molecular aspects observed in this disease. Associations between these mechanisms and clinical manifestations could thus define severity profiles and therapeutic strategies. Objectives To verify whether there is an association between lipid profile and clinical manifestations in patients with SCA and if there is a correlation between lipid profile and laboratory markers in this disease. Methodology According to the PRISMA guidelines, a systematic review of the literature was conducted by searching the MEDLINE/PubMed, LILACS, SciELO, Scopus, and Cochrane databases. Articles were screened by reading the titles and abstracts, reaching those selected for full-text reading. The included studies were published between 2010 and 2020, were fully available in the databases, and addressed the proposed theme. The risk of individual bias was assessed by using the Joanna Briggs Institute checklist and the Newcastle-Ottawa scale. Results Out of the 144 identified articles, 15 were selected for analysis, resulting in a sample size of 2,230 individuals. HDL-C, LDL-C, total cholesterol , and triglycerides were the main variables analyzed in the lipid profiles. A correlation was observed between these variables and some of the most relevant clinical events in the disease, including vaso-occlusive seizures and acute thoracic syndrome. Conclusion Lipid metabolism disorders, especially hypocholesterolemia and hypertriglyceridemia, are linked to clinical events observed in SCA, suggesting they play a relevant role in the multifactorial pathogenesis of this disease.
DOI: 10.6084/m9.figshare.21640105
title: Strain Magnitude Assessed at Rest and During Stress Echocardiography in Patients with Normal Coronary Flow Reserve

description: Abstract Background Coronary flow and myocardial contractile performance assessed by strain magnitude increase during a dobutamine stress echocardiogram (DSE). Normal coronary flow reserve (CFR) can be attained upon completion of a DSE at age-predicted maximum heart rate (HR) (HRmax = 220 - age)] or submaximal HR [(0.85) HRmax] or before completion (early CFR). Objective To ascertain the association between delta strain and HR in patients with early normal CFR. Methods This prospective study included patients whose normal CFR was obtained before the DSE was completed. Percentage of resting HR (%HRrest) = [(HRrest ÷ HRmax) 100]% and %HR CFR = [(HR at the time of CFR attainment) ÷ (HRmax) 100]% were recorded. Strain was assessed in the left ventricular region of interest, and delta strain was calculated as the difference between the measures obtained at HRrest and after the DSE was completed. Strain agreement analysis for HRrest, %HRrest, and %HR CFR was performed using the kappa coefficient. The Shapiro-Wilk test was used to assess data normality, and the Mann-Whitney test was used to compare the groups. A p-value &lt; 0.05 was considered statistically significant. Results Strain measured -23.3% ± 4.3% at baseline and -31.1% ± 4.9% during the DSE. In delta strain &gt; 8 absolute points, the ROC curves showed an area under the curve of 0.874 ± 0.07 for %HRrest (p = 0.001) and an area under the curve of 0.862 ± 0.07 for %HR CFR (p = 0.001). In delta strain &gt; 8 points, %HRrest ≤ 42.6% of HRmax and %HR CFR ≤ 62.5% of HRmax showed an accuracy of 82.9% and 79.8%, respectively. Conclusion In this study, lower HRrest and HR at the time of CFR attainment had a good association with better myocardial contractile performance, according to the change in strain magnitude.
DOI: 10.6084/m9.figshare.21640105.v1
title: Strain Magnitude Assessed at Rest and During Stress Echocardiography in Patients with Normal Coronary Flow Reserve

description: Abstract Background Coronary flow and myocardial contractile performance assessed by strain magnitude increase during a dobutamine stress echocardiogram (DSE). Normal coronary flow reserve (CFR) can be attained upon completion of a DSE at age-predicted maximum heart rate (HR) (HRmax = 220 - age)] or submaximal HR [(0.85) HRmax] or before completion (early CFR). Objective To ascertain the association between delta strain and HR in patients with early normal CFR. Methods This prospective study included patients whose normal CFR was obtained before the DSE was completed. Percentage of resting HR (%HRrest) = [(HRrest ÷ HRmax) 100]% and %HR CFR = [(HR at the time of CFR attainment) ÷ (HRmax) 100]% were recorded. Strain was assessed in the left ventricular region of interest, and delta strain was calculated as the difference between the measures obtained at HRrest and after the DSE was completed. Strain agreement analysis for HRrest, %HRrest, and %HR CFR was performed using the kappa coefficient. The Shapiro-Wilk test was used to assess data normality, and the Mann-Whitney test was used to compare the groups. A p-value &lt; 0.05 was considered statistically significant. Results Strain measured -23.3% ± 4.3% at baseline and -31.1% ± 4.9% during the DSE. In delta strain &gt; 8 absolute points, the ROC curves showed an area under the curve of 0.874 ± 0.07 for %HRrest (p = 0.001) and an area under the curve of 0.862 ± 0.07 for %HR CFR (p = 0.001). In delta strain &gt; 8 points, %HRrest ≤ 42.6% of HRmax and %HR CFR ≤ 62.5% of HRmax showed an accuracy of 82.9% and 79.8%, respectively. Conclusion In this study, lower HRrest and HR at the time of CFR attainment had a good association with better myocardial contractile performance, according to the change in strain magnitude.
DOI: 10.6084/m9.figshare.20455073.v1
title: Sedation, analgesia, and delirium management in Portugal: a survey and point prevalence study

description: ABSTRACT Objective: To establish current Portuguese critical care practices regarding analgesia, sedation, and delirium based on a comparison between the activities reported and daily clinical practice. Methods: A national survey was conducted among physicians invited to report their practice toward analgesia, sedation, and delirium in intensive care units. A point prevalence study was performed to analyze daily practices. Results: A total of 117 physicians answered the survey, and 192 patients were included in the point prevalence study. Survey and point prevalence studies reflect a high sedation assessment (92%; 88.5%), with the Richmond Agitated Sedation Scale being the most reported and used scale (41.7%; 58.2%) and propofol being the most reported and used medication (91.4%; 58.6%). Midazolam prescribing was reported by 68.4% of responders, but a point prevalence study revealed a use of 27.6%. Although 46.4% of responders reported oversedation, this was actually documented in 32% of the patients. The survey reports the daily assessment of pain (92%) using standardized scales (71%). The same was identified in the point prevalence study, with 91.1% of analgesia assessment mainly with the Behavioral Pain Scale. In the survey, opioids were reported as the first analgesic. In clinical practice, acetaminophen was the first option (34.6%), followed by opioids. Delirium assessment was reported by 70% of physicians but was performed in less than 10% of the patients. Conclusion: The results from the survey did not accurately reflect the common practices in Portuguese intensive care units, as reported in the point prevalence study. Efforts should be made specifically to avoid oversedation and to promote delirium assessment.
DOI: 10.6084/m9.figshare.20455073
title: Sedation, analgesia, and delirium management in Portugal: a survey and point prevalence study

description: ABSTRACT Objective: To establish current Portuguese critical care practices regarding analgesia, sedation, and delirium based on a comparison between the activities reported and daily clinical practice. Methods: A national survey was conducted among physicians invited to report their practice toward analgesia, sedation, and delirium in intensive care units. A point prevalence study was performed to analyze daily practices. Results: A total of 117 physicians answered the survey, and 192 patients were included in the point prevalence study. Survey and point prevalence studies reflect a high sedation assessment (92%; 88.5%), with the Richmond Agitated Sedation Scale being the most reported and used scale (41.7%; 58.2%) and propofol being the most reported and used medication (91.4%; 58.6%). Midazolam prescribing was reported by 68.4% of responders, but a point prevalence study revealed a use of 27.6%. Although 46.4% of responders reported oversedation, this was actually documented in 32% of the patients. The survey reports the daily assessment of pain (92%) using standardized scales (71%). The same was identified in the point prevalence study, with 91.1% of analgesia assessment mainly with the Behavioral Pain Scale. In the survey, opioids were reported as the first analgesic. In clinical practice, acetaminophen was the first option (34.6%), followed by opioids. Delirium assessment was reported by 70% of physicians but was performed in less than 10% of the patients. Conclusion: The results from the survey did not accurately reflect the common practices in Portuguese intensive care units, as reported in the point prevalence study. Efforts should be made specifically to avoid oversedation and to promote delirium assessment.
DOI: 10.6084/m9.figshare.21627074
title: Running dataset summary

description: This dataset could provide kinematic data of lower limbs and vertical ground reaction forces (vGRFs) during treadmill running at 12, 14, and 16km/h, as well as include the originally predicted result of the Wavelet Neural Network model. The study recruited 9 high-lever runners (3 males and 6 females) to participate in this experiment. These kinematic data and vGRFs were synchronously recorded by using the motion capture system and instrumented treadmill. The 12 kinematic variables included the velocity of segment center mass in the thigh, shank, and foot, as well as the joint ankle, joint angular velocity, and joint angular acceleration in the hip, knee, and ankle. All data on the right and left limbs were totally recorded about 540 running cycles.
DOI: 10.5281/zenodo.7375477
title: Habibpourmehraban et al Supplementary data file updated 25Nov2022

description: Supplementary data for a publication submitted to International Journal of Molecular Sciences, Habibpourmehraban et al, November 2022. This version updated to also include raw data from parallel reaction monitoring experiments.
description: Version updated 25 Nov 2022 for manuscript resubmission.
DOI: 10.5281/zenodo.7375476
title: Habibpourmehraban et al Supplementary data file updated 25Nov2022

description: Supplementary data for a publication submitted to International Journal of Molecular Sciences, Habibpourmehraban et al, November 2022. This version updated to also include raw data from parallel reaction monitoring experiments.
description: Version updated 25 Nov 2022 for manuscript resubmission.
DOI: 10.5281/zenodo.7215069
title: Dataset. Catalogue of Sites. Saronic Gulf 'Islands in-between'

description: The following catalogue was compiled in support of an article focusing on the islands of the Saronic Gulf and in particular, small islands termed there the ‘Little Saronics’. In the first part of this catalogue, the evidence is listed first by island/region, and then by site. If there are substantial chronological horizons to the site, then this forms the next division. The second part of this catalogue presents a short overview of each chronological period. This database (and the article it supports) were funded by the Enbomsdonantionsfond of Vitterhetsakademien, Sweden, under the project: 'Island-hopping in the Saronic Gulf: preliminary research in advance of a seascape-focused survey' (ENB2022-0011). I am most grateful for their support of this project.
description: The dataset will be updated monthly until December 31st.
DOI: 10.5281/zenodo.7215070
title: Dataset. Catalogue of Sites. Saronic Gulf 'Islands in-between'

description: The following catalogue was compiled in support of an article focusing on the islands of the Saronic Gulf and in particular, small islands termed there the ‘Little Saronics’. In the first part of this catalogue, the evidence is listed first by island/region, and then by site. If there are substantial chronological horizons to the site, then this forms the next division. The second part of this catalogue presents a short overview of each chronological period. This database (and the article it supports) were funded by the Enbomsdonantionsfond of Vitterhetsakademien, Sweden, under the project: 'Island-hopping in the Saronic Gulf: preliminary research in advance of a seascape-focused survey' (ENB2022-0011). I am most grateful for their support of this project.
description: The dataset will be updated monthly until December 31st.
DOI: 10.5281/zenodo.7375481
title: Dataset. Catalogue of Sites. Saronic Gulf 'Islands in-between'

description: The following catalogue was compiled in support of an article focusing on the islands of the Saronic Gulf and in particular, small islands termed there the ‘Little Saronics’. In the first part of this catalogue, the evidence is listed first by island/region, and then by site. If there are substantial chronological horizons to the site, then this forms the next division. The second part of this catalogue presents a short overview of each chronological period. This database (and the article it supports) were funded by the Enbomsdonantionsfond of Vitterhetsakademien, Sweden, under the project: 'Island-hopping in the Saronic Gulf: preliminary research in advance of a seascape-focused survey' (ENB2022-0011). I am most grateful for their support of this project.
description: The dataset will be updated monthly until December 31st.
DOI: 10.15151/esrf-es-1005220115
title: High energy CDI

description: Bragg coherent diffraction imaging with high energy X-rays
DOI: 10.5281/zenodo.6395451
title: nPOGA and nATMO

description: nPOGA: A North Pacific pacemaker experiment A North Pacific pacemaker experiment nATMO: A North Pacific atmosphere-only experiment. More details on the nPOGA and nATMO configuration can be referred to Amaya et al. (2019).
DOI: 10.5281/zenodo.6396317
title: nPOGA and nATMO

description: nPOGA: A North Pacific pacemaker experiment. nATMO: A North Pacific atmosphere-only experiment. More details on the nPOGA and nATMO configuration can be referred to Amaya et al. (2019).
DOI: 10.5281/zenodo.6395450
title: nPOGA and nATMO

description: nPOGA: A North Pacific pacemaker experiment. nATMO: A North Pacific atmosphere-only experiment. More details on the nPOGA and nATMO configuration can be referred to Amaya et al. (2019).
DOI: 10.5281/zenodo.7375378
title: nPOGA and nATMO

description: nPOGA: A North Pacific pacemaker experiment. nATMO: A North Pacific atmosphere-only experiment. More details on the nPOGA and nATMO configuration can be referred to Amaya et al. (2019).
DOI: 10.6084/m9.figshare.21220307.v1
title: Astrocyte diversity: the adult dentate gyrus is populated by layer-specific astrocyte subtypes

description: Data contain all original TIFFs of confocal images displayed in the manuscript. For most images, we here display the merge as well as the single channels images. Images that are cropped or zoomed in in the Figures are here displayed as the entire image.
DOI: 10.6084/m9.figshare.21220307
title: Astrocyte diversity: the adult dentate gyrus is populated by layer-specific astrocyte subtypes

description: Data contain all original TIFFs of confocal images displayed in the manuscript. For most images, we here display the merge as well as the single channels images. Images that are cropped or zoomed in in the Figures are here displayed as the entire image.
DOI: 10.25934/pr00007372.9
title: Available IPD datapackage for study 'A Phase III, Open-Label, Randomized Study of Atezolizumab in Combination With Bevacizumab Compared With Sorafenib in Patients With Untreated Locally Advanced or Metastatic Hepatocellular Carcinoma'

description: This study will evaluate the efficacy and safety of atezolizumab in combination with bevacizumab compared with sorafenib in participants with locally advanced or metastatic Hepatocellular Carcinoma (HCC) who have received no prior systemic treatment.
DOI: 10.25934/pr00005804.6
title: Available IPD datapackage for study 'A Phase II, Multicenter, Single-Arm Study of Atezolizumab in Patients With Locally Advanced or Metastatic Urothelial Bladder Cancer'

description: This Phase II, single-arm study is designed to evaluate the effect of atezolizumab treatment in participants with locally advanced or metastatic urothelial bladder cancer. Participants will be enrolled into 1 of 2 cohorts. Cohort 1 (reported here) will consist of participants who are treatment-naïve and ineligible for cisplatin-containing chemotherapy. Cohort 2 will contain participants who have progressed during or following a prior platinum-based chemotherapy regimen. The results of the second cohort are reported separately (NCT02108652). Participants in both cohorts will be given a 1200 milligrams (mg) intravenous (IV) dose of atezolizumab on Day 1 of 21-day cycles. Treatment of participants in Cohort 1 will continue until disease progression per Response Evaluation Criteria in Solid Tumors Version 1.1 (RECIST v1.1) or unmanageable toxicity. Treatment of participants in Cohort 2 will continue until loss of clinical benefit or unmanageable toxicity.
DOI: 10.57770/7hgtij
title: Replication Data for: Herbal Formula SS-1 Increases Tear Secretion for Sjögren's Syndrome.

description: Background: Sjögren's syndrome (SS) is an autoimmune inflammatory disease that primarily affects the exocrine glands, leading to glandular dysfunction. The hallmark symptoms of SS are dry eyes and mouth, compromising the quality of life of patients and decreasing their capacity to perform their daily activities. Objective: This study aims to evaluate the efficacy of the herbal formula SS-1 for its potential therapeutic benefits for patients with Sjögren's syndrome. Materials and Methods: The bioactivity profile of SS-1 was determined using four different SS-1 concentrations across 12 human primary cell systems of the BioMAP profile. After that, a randomized, double-blind, crossover, placebo-controlled trial was performed including 57 patients treated with SS-1 for 28 weeks. Results: Biologically multiplexed activity profiling in cell-based models indicated that SS-1 exerted anti-proliferative activity in B cells and promoted anti-inflammatory and immunomodulatory activity. In the clinical trial, Schirmer's test results revealed significant improvements in both eyes, with increases of 3.42 mm (95% CI, 2.44-4.41 mm) and 3.45 mm (95% CI, 2.32-4.59 mm), respectively, and a significant reduction in artificial tear use, which was -1.38 times/day, 95% CI, -1.95 to -0.81 times/day. Moreover, the increases in B-cell activating factor (BAFF) and B-cell maturation antigen (BCMA) levels were dampened by 53.20% (295.29 versus 555.02 pg/ml) and 58.33% (99.16 versus 169.99 pg/ml), respectively. Conclusion: SS-1 treatment significantly inhibited B-cell maturation antigen. No serious drug-related adverse effects were observed. Oral SS-1 administration may be a complementary treatment for Sjögren's syndrome.
DOI: 10.14278/rodare.1975
title: research data: Rsn-2-mediated directed foam enrichment of β-lactamase

description: the excel data attached includes the flotation data, the surface tension data, and the activity of the enzyemes before and after the flotation.
DOI: 10.14278/rodare.1974
title: research data: Rsn-2-mediated directed foam enrichment of β-lactamase

description: the excel data attached includes the flotation data, the surface tension data, and the activity of the enzyemes before and after the flotation.
DOI: 10.21227/n27q-7e06
title: VisioDECT Dataset: An Aerial Dataset for Scenario-Based Multi-Drone Detection and Identification Research

description: The deployment of unmanned aerial vehicles (UAV) for logistics and other civil purposes is consistently disrupting airspace security. Consequently, there is a scarcity of robust datasets for the development of real-time systems that can checkmate the incessant deployment of UAVs in carrying out criminal or terrorist activities. VisioDECT is a robust vision-based drone dataset for classifying, detecting, and countering unauthorized drone deployment using visual and electro-optical infra-red detection technologies.The dataset consists of 20924 sample images and annotations from 6 drone models across 3 scenarios (cloudy, sunny, and evening), at different altitudes and distances (30m-100m), and in 3 different file formats (txt, xml, csv) that was generated at 12 different locations within a period of 1 year, 8 months by a team of domain experts.The materials used for the data capturing includes drone models (Anafi-Extended, DJI FPV, DJI Phantom, EFT-E410S, Mavic2-Air, and Mavic2-Enterprise), drone controllers, mobile phone with controller application, high-definition digital cameras, and tripod stands. Each drone model was flown at different altitudes and distances at different times of day, week, and month. The video sequence of each scenario is recorded.  Using reputable software applications, each video sequence is converted to JPEG image frames of 852 x 480 pixels and stored in repositories representing each model class and scenario sub-class. To minimize error, trained professionals carried out data cleaning on each repository by manually eliciting image frames without corresponding drones at the background. Data annotation was carried out by trained experts on each scenario sub-class in 3 file formats (txt, xml, and csv) by manually drawing bounding boxes around each image file to generate corresponding label files. To ensure consistency in naming convention and minimize error, each scenario sub-class label files are named to correspond to their image files and stored in repositories accordingly. VisioDECT dataset is arranged in 6 folders (representing the 6 drone models) with each folder having 2 sub-folders (representing the images folders and labels folders). Each image folder is made up of 3 scenario folders (representing cloudy, sunny, and evening) containing the image files stored in .JPG format. Each label folder contains 3 scenario annotation files (stored in .txt, .csv, and xml format) corresponding to the 3 scenario image folders. This makes it easy for classification, detection, and other image processing simulations on the dataset using developed models or different state-of-the-art artificial intelligence (AI) models.
DOI: 10.13016/ztmh-4a0a
title: PIC simulation data for "Magnetic reconnection and instabilities in the Earth's quasi-parallel bow shock": foreshock region

description: Simulation data for a study of magnetic reconnection in foreshock waves, supported by a NASA grant 80NSSC20K1312, "Magnetic reconnection and instabilities in the Earth's quasi-parallel bow shock". Please see the data description file about details for the data.