cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.5061/dryad.d2547d81s
title: Supplementary material of article entitled: Neurological adverse events of immune checkpoint inhibitors: A systematic review of 428 cases

description: Objective: To define the clinical characteristics, management, and outcome
 of neurological immune-related adverse events (n-irAEs) of immune
 checkpoint inhibitors (ICIs). Methods: Systematic review of the literature
 following the PRISMA guidelines. Results: A total of 694 articles were
 identified. Two hundred fifty-six articles, with 428 individual patients,
 met the inclusion criteria. Reports regarding neuromuscular disorders
 (319/428, 75%) were more frequent than those on central nervous system
 (CNS) disorders (109/428, 25%). The most common n-irAEs reports
 were: myositis (136/428, 32%), Guillain-Barré syndrome and other
 peripheral neuropathies (94/428, 22%), myasthenic syndromes (58/428, 14%),
 encephalitis (56/428, 13%), cranial neuropathies (31/428, 7%), meningitis
 (13/428, 3%), CNS demyelinating diseases (8/428, 2%), and myelitis (7/428,
 2%). Other CNS disorders were detected in 25/428 (6%) patients. Compared
 to the whole sample, myasthenic syndromes were significantly more
 Ab-positive (33/56, 59%; p&lt;0.001). Anti-PD-1/PD-L1 were more
 frequent in myasthenic syndromes (50/58, 86%; p=0.005) and less common in
 meningitis (2/13, 15%; p&lt;0.001) and cranial neuropathies
 (13/31, 42%; p=0.005). Anti-CTLA-4 ICIs were more frequent in meningitis
 (8/13, 62%; p&lt;0.001) and less common in encephalitis (2/56, 4%;
 p=0.009) and myositis (12/136, 9%; p=0.01). Combination of different ICIs
 was more frequent in cranial neuropathies (12/31, 39%; p=0.005). Tumor
 types were highly heterogeneous, but melanoma was more frequent in
 patients with peripheral neuropathies (64/94, 68%; p=0.003) and less
 common in those with encephalitis (19/56, 34%; p=0.001). The highest
 mortality rate was reached in myasthenic syndromes (28%). Conclusion:
 Considering the increasing use of ICI therapy in the forthcoming future,
 this information can be valuable in assisting neurologists and oncologists
 in early n-irAEs diagnosis and treatment.
description: Syndrome references were collected by means of a comprehensive
 search in PubMed, PubMed Central (PMC), Cochrane, Scopus, and Web of
 Science; additional articles were retrieved by searching through the
 reference list of all articles. References are divided by syndromes, as
 stated in the article.  Supplementary tables file
 contains tables with distributions (value, percentages) and statistical
 analysis (with p values) of associations between ab positivity, ICIs used,
 outcome, with different syndromes.  PRISMA (Preferred
 Reporting Items for Systematic Reviews and Meta-Analyses) checklist
 represents an evidence-based minimum set of items for reporting in
 Systematic Reviews. PRISMA flow diagram shows the process for selection of
 articles/patients, from the initial search to final selection (with
 reasons for exclusion).
DOI: 10.5061/dryad.rxwdbrv6j
title: Clustering of loci controlling species differences in male chemical bouquets of sympatric Heliconius butterflies

description: The degree to which loci promoting reproductive isolation cluster in the
 genome – i.e. the genetic architecture of reproductive isolation - can
 influence the tempo and mode of speciation. Tight linkage between these
 loci can facilitate speciation in the face of gene flow. Pheromones play a
 role in reproductive isolation in many Lepidoptera species, and the role
 of endogenously-produced compounds as secondary metabolites decreases the
 likelihood of pleiotropy associated with many barrier loci. Heliconius
 butterflies use male sex pheromones to both court females (aphrodisiac
 wing pheromones) and ward off male courtship (male-transferred
 anti-aphrodisiac genital pheromones), and it is likely that these
 compounds play a role in reproductive isolation between Heliconius
 species. Using a set of backcross hybrids between H. melpomene and H.
 cydno, we investigated the genetic architecture of putative male pheromone
 compound production. We found a set of 40 significant quantitative trait
 loci (QTL) representing 33 potential pheromone compounds. QTL clustered
 significantly on two chromosomes, chromosome 8 for genital compounds and
 chromosome 20 for wing compounds, and chromosome 20 was enriched for
 potential pheromone biosynthesis genes. There was minimal overlap between
 pheromone QTL and known QTL for mate choice and color pattern.
 Nonetheless, we did detect linkage between a QTL for wing androconial area
 and optix, a color pattern locus known to play a role in reproductive
 isolation in these species. This tight clustering of putative pheromone
 loci might contribute to coincident reproductive isolating barriers,
 facilitating speciation despite ongoing gene flow.
description: This dataset consists of n major data subsets: pheromone analysis
 of parent species <em>Heliconius cydno</em> and <em>H.
 melpomene </em>and F1 and backcross individuals between the two
 species (raw GC-MS output files and data tables; note that genital data
 are included here but parental and cross wing pheromone data are
 separately archived in Dryad at https://doi.org/10.5061/dryad.crjdfn31b); androconial analysis of the same individuals (data table and image files); and QTL mapping information (linkage maps and QTL analysis scripts). GC-MS data were analyzed with AMDIS to produce data tables with compound amounts. Image files of wing area were analyzed using GIMP (GNU Image Manipulation Program) for hindwing and hindwing androconial area. QTL linkage maps were produced from whole genome data (separately archived on ENA under project PRJEB34160) and scripts for analysis of QTL using the R/qtl2 package are included.
description: Raw GC-MS files may be viewed and analyzed in the free analysis
 software AMDIS. "MP" in files and filenames refers
 to <em>H. melpomene</em> (MP from
 "<em>melpomene </em>Panama") and "CP"
 to <em>H. cydno</em>.
DOI: 10.5281/zenodo.18395995
title: Spatial distribution of organochlorine pesticide serum concentrations in Mexican children and adolescents living in and out the polluted Atoyac watershed basin - dataset

description: The dataset represents the control group of a population-based case control study investigating the association between acute leukemia and environmental factors in Mexican children and adolescents under 20 years old, conducted between 2021 and 2024 in three central-southern states: Puebla, Oaxaca, and Tlaxcala. This was used for the manuscript "Spatial distribution of organochlorine pesticide serum concentrations in Mexican children and adolescents living in and out the polluted Atoyac watershed basin".
DOI: 10.5281/zenodo.18395996
title: Spatial distribution of organochlorine pesticide serum concentrations in Mexican children and adolescents living in and out the polluted Atoyac watershed basin - dataset

description: The dataset represents the control group of a population-based case control study investigating the association between acute leukemia and environmental factors in Mexican children and adolescents under 20 years old, conducted between 2021 and 2024 in three central-southern states: Puebla, Oaxaca, and Tlaxcala. This was used for the manuscript "Spatial distribution of organochlorine pesticide serum concentrations in Mexican children and adolescents living in and out the polluted Atoyac watershed basin".
DOI: 10.5061/dryad.gtht76hjz
title: Microsatellite genotypes and ITS2 DNA sequence data for Seriatopora hystrix

description: Coral reefs provide essential goods and services but are degrading at an
 alarming rate due to local and global anthropogenic stressors. The main
 limitation that prevents the implementation of adequate conservation
 measures is that connectivity and genetic structure of populations are
 poorly known. Here, the genetic diversity and connectivity of the brooding
 scleractinian coral, Seriatopora hystrix were assessed at two
 scales by genotyping ten microsatellite markers for 356 individual
 colonies. Seriatopora hystrix showed high differentiation, both at large
 scale between the Red Sea and the Western Indian Ocean (WIO), and at
 smaller scale along the coast of East Africa.As such high levels of
 differentiation might indicate the presence of more than one species, a
 haploweb analysis was conducted with the nuclear marker ITS2, confirming
 that the Red Sea populations are genetically distinct from the WIO
 ones.Based on microsatellite analyses three groups could be distinguished
 within the WIO: (I) north Madagascar, (II) south-west Madagascar together
 with one site in northern Mozambique (Nacala), and (III) all other sites
 in northern Mozambique, Tanzania and Kenya. These patterns of restricted
 connectivity could be explained by the short pelagic larval duration of S.
 hystrix, and/or by oceanographic factors, such as eddies in the Mozambique
 Channel (causing larval retention in northern Madagascar but facilitating
 dispersal from northern Mozambique towards south-west Madagascar). This
 study provides an additional line of evidence supporting the conservation
 priority status of the Northern Mozambique Channel and should inform coral
 reef management decisions in the region.
DOI: 10.5061/dryad.qv9s4mwcr
title: Stability of elemental content correlates with plant resistance to soil impoverishment

description: Aims We investigated whether plant resistance to soil impoverishment would
 depend on their flexibility in taking up nutrients and on maintaining
 elemental stoichiometry. Methods We mixed sand with grassland soil in mass
 proportions of 0, 10, 30, 50 and 70% to simulate soil impoverishment as
 caused by a gradient of desertification intensity and examined how plant
 nitrogen (N) uptake (15NH4NO3 and NH415NO3 labelling) and nutrient
 stoichiometry were associated with plant growth responses of a sedge
 (Carex duriuscula) and a forb (Potentilla chinensis). Results With
 increasing intensity of soil impoverishment, plant biomass, cover and
 density decreased for C. duriuscula, but not for P. chinensis.
 Interestingly, uptake of both 15NO3- and 15NH4+ increased for the sedge
 but not for the forb, with the former species showing stronger preference
 of NO3-. However, the sedge showed decreasing nutrient contents and
 concentrations of phosphorus (P) and magnesium (Mg), and thus increasing
 stoichiometric ratios of N:P and calcium (Ca):Mg. In contrast, the forb
 maintained its biomass by showing strong stability in nutrient content,
 concentration and stoichiometry. Conclusions Stability of N uptake and
 nutrient stoichiometry were associated with higher resistance to soil
 impoverishment of the forb than the sedge. Our study highlights the
 importance of stability in nutrient uptake and stoichiometry for
 determining plant-species resistance to nutrient-poor conditions.
DOI: 10.5061/dryad.fn2z34ts5
title: Deep desulfurisation performance of thiophene with deep eutectic solvents loaded carbon nanotubes composites

description: One source of air pollution is the combustion of sulfur compounds in fuel
 oil. Reducing sulfur content in fuel oil has become a hot issue demanding
 timely solutions. Using ionic liquids (ILs) and deep eutectic solvents
 (DESs) to remove sulfides in fuel oil has achieved good results presently.
 However, since DESs are liquid and their transportation and separation are
 inconvenient, a new way is proposed that the DESs are loaded on the carbon
 nanotubes (CNTs) with large specific surface area and good chemical
 stability. A series of composites materials (DESs/CNTs) were prepared.
 Finally, they are applied to the removal of sulfides in fuel oil. This
 loading method, which imparts introduced unique Physico-chemical
 properties of the DESs to the carrier materials, preserves both advantages
 while overcoming some of the problems with DESs. The interaction between
 DESs and CNTs is mutual promotion. Therefore, this study has important
 theoretical significance and industrial application value. Under optimal
 conditions, when the reagent ChCl/p-TsOH (1 : 2) was loaded on
 multi-walled carbon nanotubes CNTs (OD=30-60nm) to prepare the composite
 material (ChCl/p-TsOH)/CNTs, the single desulfurisation rate of the
 composite material was 95.8%. Finally, the catalytic/oxidation mechanism
 was studied systematically and this work would provide a green route for
 the desulfurisation of fuels.
description: Analysis of sulfur concentration in simulated desulfurised oil
 was by gas chromatography. The chromatographic conditions are showed as
 follows: chromatogram column: HP-5; injection volume: 0.06 μL; carrier gas
 (N<sub>2</sub>): 210 mL/min; H<sub>2</sub>: 40
 mL/min; air: 350 mL/min; flux: 1.6 mL/min, constant current mode; inlet
 temperature: 250°C; detector temperature: 250°C; column temperature:
 heating from 60°C to 220°C with 30°C/min increase. Th concentration was
 determined by standard internal method. The n-hexadecane was chosen as the
 standard internal solvent and concentration was 2000 ppm. The correlation
 coefficient was found to be 0.99941.
DOI: 10.5061/dryad.q2bvq83h9
title: Data From: Phylogenomics reveals accelerated late Cretaceous diversification of bee flies (Diptera: Bombyliidae)

description: Bombyliidae is a very species-rich and widespread family of parasitoid
 flies with more than 250 genera classified into 17 extant subfamilies.
 However, little is known about their evolutionary history or how their
 present-day diversity was shaped. Transcriptomes of 15 species and
 anchored hybrid enrichment (AHE) sequence captures of 86 species,
 representing 94 bee fly species and 14 subfamilies, were used to
 reconstruct the phylogeny of Bombyliidae. We integrated data from
 transcriptomes across each of the main lineages in our AHE tree to build a
 data set with more genes (550 loci versus 216 loci) and higher support
 levels. Our overall results show strong congruence with the current
 classification of the family, with 11 out of 14 included subfamilies
 recovered as monophyletic. Heterotropinae and Mythicomyiinae are
 successive sister groups to the remainder of the family. We examined the
 evolution of key morphological characters through our phylogenetic
 hypotheses and show that neither the “sand chamber subfamilies” nor the
 “Tomophthalmae” are monophyletic in our phylogenomic analyses. Based on
 our results, we reinstate two tribes at the subfamily level (Phthiriinae
 stat. rev. and Ecliminae stat. rev.) and we include the genus Sericosoma
 Macquart (previously incertae sedis) in the subfamily Oniromyiinae,
 bringing the total number of bee fly subfamilies to 19. Our dating
 analyses indicate a Jurassic origin of the family (165–194 Ma), with the
 sand chamber evolving early in bee fly evolution, in the late Jurassic or
 mid-Cretaceous (100–165 Ma). We hypothesize that the angiosperm radiation
 and the hothouse climate established during the late Cretaceous
 accelerated the diversification of bee flies, by providing an expanded
 range of resources for the parasitoid larvae and nectarivorous adults.
DOI: 10.5061/dryad.4j0zpc891
title: Adaptation to elevation but limited local adaptation in an amphibian

description: We performed a reciprocal transplant experiment to estimate “parallel”
 adaptation to elevation and “unique” adaptation to local sites at the same
 elevation, using the frog Rana temporaria in the Swiss Alps. It is
 important to distinguish these two processes because they have different
 implications for population structure and ecological specialization.
 Larvae were reared from hatching to metamorphosis within enclosures
 installed in their pond of origin, in three foreign ponds at the same
 elevation, and in four ponds at different elevation (1500-2000 m higher or
 lower). There were two source populations from each elevation, and adults
 were held in a common environment for one year before they were crossed to
 produce offspring for the experiment. Fitness was a measure that
 integrated larval survival, development rate, and body size. Parallel
 adaptation to elevation was indicated by an advantage at the home
 elevation (11.5% fitness difference at low elevation and 47% at high
 elevation). This effect was stronger than that observed in most other
 studies, according to a survey of previous transplant experiments across
 elevation (N = 8 animal species and 71 plants). Unique local adaptation
 within elevational zones was only 0.3-0.7 times as strong as parallel
 adaptation, probably because gene flow is comparatively high among nearby
 wetlands at the same elevation. The home-elevation advantage may reduce
 gene flow across the elevational gradient and enable the evolution of
 habitat races specialized on elevation.
description: Data loggers, measuring individual tadpoles, extracting data from
 the literature.
description: Explained in the README.txt file, the Excel files, and the R
 scripts.
DOI: 10.15468/dl.7xebcx
title: Occurrence Download

description: A dataset containing 3361 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Cercis canadensis",
 "HasCoordinate is true",
 "BasisOfRecord is one of (Specimen)"
 ]
}

 The dataset includes 3361 records from 196 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0002605-260126135527185/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.pbx8zv
title: Occurrence Download

description: A dataset containing 1856631 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Piranga olivacea"
 ]
}

 The dataset includes 1856631 records from 289 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0002570-260126135527185/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.7280/d18h5v
title: Spatiotemporal analysis of wildfires in California from 2000 to 2019

description: The environmental pollution, property losses and casualties caused by
 wildfires in California are getting worse by the year. To minimize the
 interference of wildfires on economic and social development, and
 formulate targeted mitigation strategies, it is imperative to understand
 the scale and extent of previous wildfire occurrences. In this study, we
 first investigated the temporal distributions of past wildfires in
 California divided by size and causes and analyzed the changes observed in
 the past two decades against the last century. The trend of wildfires in
 different time scales (yearly and monthly), as well as the distribution of
 wildfires across different spatial scales (administrative units, climate
 divisions in California from 2000 to 2019) were also studied. Furthermore,
 to extract the significant variables on the risk of wildfire occurrence,
 multivariate analyses of environmental and human-related variables with
 wildfire densities were carried out. The results show that the wildfire
 density distribution of the burned area in California conforms to the
 characteristics of the Pareto distribution. Over the past two decades, the
 frequency of small (&lt; 500 acres), human-caused wildfires has
 increased most rapidly, and they are widely distributed in central and
 western California. The wildfire season has lengthened and the peak months
 have been advanced from August to July. In terms of the variables related
 to the risk of wildfire occurrence, the temperature, vapor pressure
 deficit, grass cover, and the distance to roads are crucial. This study
 reveals the relationship between environmental and social background
 conditions and the spatial-temporal distribution of wildfires, which can
 provide a reference for wildfire management, the formulation of future
 targeted wildfire emergency plans, and the planning of future land use in
 California.
DOI: 10.5061/dryad.h9w0vt4g9
title: Endocannabinoid signalling in stem cells and cerebral organoids drives differentiation to deep layer projection neurons via CB1 receptors

description: The endocannabinoid (eCB) system, via cannabinoid CB1 receptor, regulates
 neurodevelopment by controlling neural progenitor proliferation and
 neurogenesis. CB1 receptor signalling in vivo drives corticofugal deep
 layer projection neuron development through the regulation of BCL11B and
 Satb2 transcription factors. Here, we investigated the role of eCB
 signalling in mouse pluripotent embryonic stem cell-derived neuronal
 differentiation. Characterization of the eCB system revealed increased
 expression of eCB-metabolizing enzymes, eCB ligands and CB1 receptors
 along neuronal differentiation. CB1 receptor knockdown inhibited neuronal
 differentiation of deep layer neurons and increased upper layer neuron
 generation, and this phenotype was rescued by CB1 re-expression.
 Pharmacological regulation with CB1 receptor agonists or elevation of eCB
 tone with a monoacylglycerol lipase inhibitor promoted neuronal
 differentiation of deep layer neurons at the expense of upper layer
 neurons. Patch-clamp analyses revealed that enhancing cannabinoid
 signalling facilitated neuronal differentiation and functionality.
 Noteworthy, incubation with CB1 receptor agonists during human
 iPSC-derived cerebral organoid formation also promoted the expansion of
 BCL11B+ neurons. These findings unveil a cell-autonomous role of eCB
 signalling that, via CB1 receptor, promotes mouse and human deep layer
 cortical neuron development.
DOI: 10.5061/dryad.wwpzgmshf
title: Data from: Geographical patterns in phylogenetic diversity of Chinese woody plants and its application for conservation planning

description: Aim: Biodiversity hotspots are widely used as conservation priorities to
 preserve the tree of life. However, many conservation practices identify
 biodiversity hotspots without considering phylogenetic diversity (PD),
 which reflects total evolutionary history and feature diversity of a
 region. Moreover, conservation planning rarely distinguishes between neo-
 and paleo-biodiversity hotspots despite their differences. Here, we 1)
 estimated large-scale patterns in PD of woody plants, 2) identified neo-
 and paleo-biodiversity hotspots, and 3) demonstrated their implication in
 conservation planning, with special focus on Hengduan Mountains and
 southern China. Location: China. Methods: Distributions
 of 11,405 woody species from the Atlas of Woody Plants in China were
 updated, and were transformed into a grid of 50 × 50 km2. By integrating
 distribution maps with a genus-level phylogeny of angiosperms, we
 estimated Faith’s PD of each grid cell and evaluated the contribution of
 species relatedness to PD at given levels of species diversity (i.e.
 standardized PD, sPD) using regressions and three null models. Then we
 identified areas with significantly lower or higher sPD than expected as
 neo- and paleo-hotspots and estimated the coverage of protected areas in
 these regions. Results: Species diversity and PD decreased towards the
 north. Southern China had high species diversity, PD and sPD, while
 Hengduan Mountains had high species diversity and PD but low sPD. The
 coverage of protected areas in southern China was less than half of that
 in Hengduan Mountains and entire China. Main conclusions: Our results
 identified Hengduan Mountains as a neo-hotspot and southern China as a
 paleo-hotspot, highlighting their importance for biodiversity
 conservation. Compared to Hengduan Mountains, southern China has low
 coverage of protected areas, which calls for more conservation attention.
 Our study demonstrates a way of incorporating the phylogenetic component
 in the identification of neo- and paleo-hotspots, and hence of achieving a
 more complete perception of biodiversity patterns for conserving the tree
 of life.