cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.25450414
title: Supplementary Material for: Neuropsychiatric profiles and cerebral amyloid burden in adults without dementia

description: Introduction: We comprehensively evaluated how self- and informant-reported neuropsychiatric symptoms (NPS) differentially associated with cerebral amyloid-beta (Aβ) PET levels in older adults without dementia.
Methods: 221 participants (48% female, age=73.4y±8.4, CDR=0 [n=184] or 0.5 [n=37]) underwent an Aβ-PET scan (Florbetapir or PIB), comprehensive neuropsychological testing, and self-reported (Geriatric Depression Scale- 30 item), and informant-reported interview (Neuropsychiatric Inventory Questionnaire) of NPS. Cerebral Aβ burden was quantified using Centiloids (CL). NPI-Q and GDS-30 queried presence of NPS within 4 subdomains and 6 subscales, respectively. Regression models examined the relationship between NPS and Aβ-PET CL.
Results: Both higher self- and informant-reported NPS were associated with higher Aβ burden. Among specific NPI-Q subdomains, informant-reported changes in depression, anxiety, and irritability were all associated with higher Aβ-PET. Similarly, self-reported (GDS-30) subscales of depression, apathy, anxiety, and cognitive concern associated with higher Aβ-PET. When simultaneously entered, only self-reported cognitive concern associated with Aβ-PET in the GDS-30 model, while both informant-reported anxiety and depression associated with Aβ-PET in the NPI-Q model. Clinical status moderated the association between self-reported NPS and Aβ-PET, such that the positive relationship between self-perceived NPS and Aβ burden strengthened with increasing functional difficulties.
Conclusions: In a cohort of older adults without dementia, both self- and informant-reported measures of global NPS, particularly patient-reported cognitive concerns and informant-reported anxiety and depression, corresponded with cerebral Aβ burden. NPS may appear early in the prodromal disease state and relate to initial AD proteinopathy burden, a relationship further exaggerated in those with greater clinical severity.
DOI: 10.5281/zenodo.10848456
title: [IO Islamic 2388] ديوان شوكت

description: Dîwân-i-Shaukat

This manuscript is now IO Islamic 1630 in the India Office collections.

[metadata: Hermann Ethé, Catalogue of Persian Manuscripts in the Library of the India Office, 2 vols. (Oxford: India Office, 1903): volume 1, number 2388 here with notations and hyperlinks].


1630

Shaukat’s ghazals.

This copy of Shaukat’s lyrical poems contains the ghazals, intermixed with rubâ’îs and fards, arranged alphabetically in two series.

First series, on ff. 1b-130a, beginning as usually: خدايا رنگ الخ.

This series goes from the rhyme-letter ا to ى.

Second series, on ff. 130b-158b, beginning with a rubâ’î:

رخساره نمود همچو پاى همه را الخ

This series is separated from the first by four rubâ’îs, which stand outside the alphabetical system, and goes down from the rhyme-letter ا to م only.

Dated the 3rd of Ramaḍân, A.H. ١١٤ (1140 ? or 1104 ?=A.D. 1728, April 13, or 1693, May 8), by Ḥâfiż Muḥammad Ṣâliḥ, son of Ḥâfiż Abû-alkhair. Calcutta, March, 1806.

No. 2388, ff. 158, 2 coll., each ll. 11; Nasta’lîḳ; size, 81/4 in. by 45/8 in.
DOI: 10.5281/zenodo.10848457
title: [IO Islamic 2388] ديوان شوكت

description: Dîwân-i-Shaukat

This manuscript is now IO Islamic 1630 in the India Office collections.

[metadata: Hermann Ethé, Catalogue of Persian Manuscripts in the Library of the India Office, 2 vols. (Oxford: India Office, 1903): volume 1, number 2388 here with notations and hyperlinks].


1630

Shaukat’s ghazals.

This copy of Shaukat’s lyrical poems contains the ghazals, intermixed with rubâ’îs and fards, arranged alphabetically in two series.

First series, on ff. 1b-130a, beginning as usually: خدايا رنگ الخ.

This series goes from the rhyme-letter ا to ى.

Second series, on ff. 130b-158b, beginning with a rubâ’î:

رخساره نمود همچو پاى همه را الخ

This series is separated from the first by four rubâ’îs, which stand outside the alphabetical system, and goes down from the rhyme-letter ا to م only.

Dated the 3rd of Ramaḍân, A.H. ١١٤ (1140 ? or 1104 ?=A.D. 1728, April 13, or 1693, May 8), by Ḥâfiż Muḥammad Ṣâliḥ, son of Ḥâfiż Abû-alkhair. Calcutta, March, 1806.

No. 2388, ff. 158, 2 coll., each ll. 11; Nasta’lîḳ; size, 81/4 in. by 45/8 in.
DOI: 10.5281/zenodo.10848303
title: Artifacts for "Reviewing War: Unconventional User Reviews as a Side Channel to Circumvent Information Controls"

description: List of keywords used to build the text classifier for the paper Reviewing War: Unconventional User Reviews as a Side Channel to Circumvent Information Controls. For more information on how these keywords were obtained, see the "Data Labeling" section of this paper.

The provided CSV file contains 3 columns:



"keyword": Lowercased keyword in either English, Russian, Ukranian or Polish.

"weight": Score indicating the keyword's war-related affinity, with 3 being the most related. Negative weights are used to correct for exceptions in our classifier.

"topic": Subject of the keyword used for topic analysis.
DOI: 10.5281/zenodo.10848304
title: Artifacts for "Reviewing War: Unconventional User Reviews as a Side Channel to Circumvent Information Controls"

description: List of keywords used to build the text classifier for the paper Reviewing War: Unconventional User Reviews as a Side Channel to Circumvent Information Controls. For more information on how these keywords were obtained, see the "Data Labeling" section of this paper.

The provided CSV file contains 3 columns:



"keyword": Lowercased keyword in either English, Russian, Ukranian or Polish.

"weight": Score indicating the keyword's war-related affinity, with 3 being the most related. Negative weights are used to correct for exceptions in our classifier.

"topic": Subject of the keyword used for topic analysis.
DOI: 10.6084/m9.figshare.22215114
title: Reproductive outcomes in couples with sporadic miscarriage after embryonic chromosomal microarray analysis

description: Chromosomal microarray analysis (CMA) has been widely applied to genetic diagnosis in miscarriages in clinical practice. However, the prognostic value of CMA testing of products of conception (POCs) after the first clinical miscarriage remains unknown. The aim of this study was to evaluate the reproductive outcomes after embryonic genetic testing by CMA in SM couples. In this retrospective study, a total of 1142 SM couples referred for embryonic genetic testing by CMA, and 1022 couples were successfully followed up after CMA. Among 1130 cases without significant maternal cell contamination, pathogenic chromosomal abnormalities were detected in 680 cases (60.2%). The subsequent live birth rate did not differ significantly between couples with chromosomally abnormal and normal miscarriage (88.6% vs. 91.1%, <i>p</i> = .240), as well as the cumulative live birth rate (94.5% vs. 96.7%, <i>p</i> = .131). Couples with partial aneuploid miscarriage had a higher likelihood of spontaneous abortion both in the subsequent pregnancy (19.0% vs. 6.5%, <i>p</i> = .037) and cumulative pregnancies (19.0% vs. 6.8%, <i>p</i> = .044) when compared with couples with chromosomally normal miscarriage. SM couples with chromosomally abnormal miscarriage manifested with a similar reproductive prognosis to couples with chromosomally normal miscarriage. Key messagesCMA testing of POCs could provide an accurate genetic diagnosis for couples with SM.The live birth rate of couples with partial aneuploid miscarriage was as high as couples with chromosomally normal miscarriage, despite a higher risk of adverse pregnancy event.Among couples with the most common single aneuploid miscarriage, the cumulative live birth rates of couples with trisomy 16, sex chromosomal abnormalities and trisomy 22 were 94.1%, 95.8% and 84.0%, respectively. CMA testing of POCs could provide an accurate genetic diagnosis for couples with SM. The live birth rate of couples with partial aneuploid miscarriage was as high as couples with chromosomally normal miscarriage, despite a higher risk of adverse pregnancy event. Among couples with the most common single aneuploid miscarriage, the cumulative live birth rates of couples with trisomy 16, sex chromosomal abnormalities and trisomy 22 were 94.1%, 95.8% and 84.0%, respectively.
DOI: 10.6084/m9.figshare.22215114.v1
title: Reproductive outcomes in couples with sporadic miscarriage after embryonic chromosomal microarray analysis

description: Chromosomal microarray analysis (CMA) has been widely applied to genetic diagnosis in miscarriages in clinical practice. However, the prognostic value of CMA testing of products of conception (POCs) after the first clinical miscarriage remains unknown. The aim of this study was to evaluate the reproductive outcomes after embryonic genetic testing by CMA in SM couples. In this retrospective study, a total of 1142 SM couples referred for embryonic genetic testing by CMA, and 1022 couples were successfully followed up after CMA. Among 1130 cases without significant maternal cell contamination, pathogenic chromosomal abnormalities were detected in 680 cases (60.2%). The subsequent live birth rate did not differ significantly between couples with chromosomally abnormal and normal miscarriage (88.6% vs. 91.1%, <i>p</i> = .240), as well as the cumulative live birth rate (94.5% vs. 96.7%, <i>p</i> = .131). Couples with partial aneuploid miscarriage had a higher likelihood of spontaneous abortion both in the subsequent pregnancy (19.0% vs. 6.5%, <i>p</i> = .037) and cumulative pregnancies (19.0% vs. 6.8%, <i>p</i> = .044) when compared with couples with chromosomally normal miscarriage. SM couples with chromosomally abnormal miscarriage manifested with a similar reproductive prognosis to couples with chromosomally normal miscarriage. Key messagesCMA testing of POCs could provide an accurate genetic diagnosis for couples with SM.The live birth rate of couples with partial aneuploid miscarriage was as high as couples with chromosomally normal miscarriage, despite a higher risk of adverse pregnancy event.Among couples with the most common single aneuploid miscarriage, the cumulative live birth rates of couples with trisomy 16, sex chromosomal abnormalities and trisomy 22 were 94.1%, 95.8% and 84.0%, respectively. CMA testing of POCs could provide an accurate genetic diagnosis for couples with SM. The live birth rate of couples with partial aneuploid miscarriage was as high as couples with chromosomally normal miscarriage, despite a higher risk of adverse pregnancy event. Among couples with the most common single aneuploid miscarriage, the cumulative live birth rates of couples with trisomy 16, sex chromosomal abnormalities and trisomy 22 were 94.1%, 95.8% and 84.0%, respectively.
DOI: 10.18715/ipgp.2023.lqdzz72n
title: Simulations of dune morphology under tri-directional wind regimes

description: Dune morphology was simulated using coupled models of wind flow and sand transport for 4728 tri-directional wind regimes and bed conditions. Resources supporting this work were provided by the NASA High-End Computing (HEC) Program through the NASA Advanced Supercomputing (NAS) Division at Ames Research Center from September 2019 to September 2022.
DOI: 10.6084/m9.figshare.25158414.v14
title: “I remember when … ”: The impact of reminiscence therapy on discourse production in older adults with cognitive impairment

description: <b>Purpose:</b> Positive outcomes following reminiscence therapy have been reported for older adults with mild cognitive impairment and dementia in cognition and quality of life and, in a small number of studies, communication. Despite the close relationship between cognition and language, the impact on communication has received limited attention. This study aimed to investigate whether the spoken discourse of older adults with mild cognitive impairment or dementia could be improved within the genre of <i>nostalgic recounts</i> following group reminiscence therapy, and whether change generalised to everyday discourse. <b>Method:</b> Four females (mean: 87 years, SD: 7.3) who lived in a residential aged care facility and were diagnosed with mild (<i>n</i> = 2) or major (<i>n</i> = 2) neurocognitive impairment were recruited to attend a group reminiscence programme delivered in eight one-hour treatment sessions over four weeks. Multiple baseline samples of discourse were obtained in the week prior to intervention to monitor stability. Macrostructure, rate, informativeness and efficiency of discourse production were measured to identify change within nostalgic recounts and monitor evidence of generalised change in everyday discourse genres. Cognitive performance and quality of life were also monitored. <b>Result:</b> While variability was evident, significant increases in macrostructure and richness of nostalgic recounts were found for two participants, with significant generalisation to everyday discourse. Both participants had diagnoses of mild cognitive impairment. No significant improvements were seen in cognition or quality of life with all participants. <b>Conclusion:</b> This study provides promising evidence for the spoken recall of memories having the potential to improve the communication of people with neurocognitive disorders, with some indication that people with milder impairment may be more amenable to this form of intervention. Nostalgic recounts may provide an explicit context in which speech-language pathologists can facilitate the planning of spoken production in people with cognitive impairment, and influence speaking in everyday contexts.
DOI: 10.6084/m9.figshare.25158414
title: “I remember when … ”: The impact of reminiscence therapy on discourse production in older adults with cognitive impairment

description: <b>Purpose:</b> Positive outcomes following reminiscence therapy have been reported for older adults with mild cognitive impairment and dementia in cognition and quality of life and, in a small number of studies, communication. Despite the close relationship between cognition and language, the impact on communication has received limited attention. This study aimed to investigate whether the spoken discourse of older adults with mild cognitive impairment or dementia could be improved within the genre of <i>nostalgic recounts</i> following group reminiscence therapy, and whether change generalised to everyday discourse. <b>Method:</b> Four females (mean: 87 years, SD: 7.3) who lived in a residential aged care facility and were diagnosed with mild (<i>n</i> = 2) or major (<i>n</i> = 2) neurocognitive impairment were recruited to attend a group reminiscence programme delivered in eight one-hour treatment sessions over four weeks. Multiple baseline samples of discourse were obtained in the week prior to intervention to monitor stability. Macrostructure, rate, informativeness and efficiency of discourse production were measured to identify change within nostalgic recounts and monitor evidence of generalised change in everyday discourse genres. Cognitive performance and quality of life were also monitored. <b>Result:</b> While variability was evident, significant increases in macrostructure and richness of nostalgic recounts were found for two participants, with significant generalisation to everyday discourse. Both participants had diagnoses of mild cognitive impairment. No significant improvements were seen in cognition or quality of life with all participants. <b>Conclusion:</b> This study provides promising evidence for the spoken recall of memories having the potential to improve the communication of people with neurocognitive disorders, with some indication that people with milder impairment may be more amenable to this form of intervention. Nostalgic recounts may provide an explicit context in which speech-language pathologists can facilitate the planning of spoken production in people with cognitive impairment, and influence speaking in everyday contexts.
DOI: 10.6084/m9.figshare.25158414.v16
title: “I remember when … ”: The impact of reminiscence therapy on discourse production in older adults with cognitive impairment

description: <b>Purpose:</b> Positive outcomes following reminiscence therapy have been reported for older adults with mild cognitive impairment and dementia in cognition and quality of life and, in a small number of studies, communication. Despite the close relationship between cognition and language, the impact on communication has received limited attention. This study aimed to investigate whether the spoken discourse of older adults with mild cognitive impairment or dementia could be improved within the genre of <i>nostalgic recounts</i> following group reminiscence therapy, and whether change generalised to everyday discourse. <b>Method:</b> Four females (mean: 87 years, SD: 7.3) who lived in a residential aged care facility and were diagnosed with mild (<i>n</i> = 2) or major (<i>n</i> = 2) neurocognitive impairment were recruited to attend a group reminiscence programme delivered in eight one-hour treatment sessions over four weeks. Multiple baseline samples of discourse were obtained in the week prior to intervention to monitor stability. Macrostructure, rate, informativeness and efficiency of discourse production were measured to identify change within nostalgic recounts and monitor evidence of generalised change in everyday discourse genres. Cognitive performance and quality of life were also monitored. <b>Result:</b> While variability was evident, significant increases in macrostructure and richness of nostalgic recounts were found for two participants, with significant generalisation to everyday discourse. Both participants had diagnoses of mild cognitive impairment. No significant improvements were seen in cognition or quality of life with all participants. <b>Conclusion:</b> This study provides promising evidence for the spoken recall of memories having the potential to improve the communication of people with neurocognitive disorders, with some indication that people with milder impairment may be more amenable to this form of intervention. Nostalgic recounts may provide an explicit context in which speech-language pathologists can facilitate the planning of spoken production in people with cognitive impairment, and influence speaking in everyday contexts.
DOI: 10.6084/m9.figshare.7931738
title: Assessment of potentially abuse-related events in two phase 3 studies of NKTR-181, a novel opioid analgesic, using the MADDERS® system (Misuse, Abuse, and Diversion Drug Event Reporting System)

description: <b>Objective:</b> To prospectively evaluate the abuse potential of NKTR-181, a novel opioid analgesic, in two phase 3 clinical trials using a newly developed reporting system: the Misuse, Abuse, and Diversion Drug Event Reporting System (MADDERS®). <b>Methods:</b> SUMMIT-07 was an enriched enrollment randomized withdrawal study that examined the safety and efficacy of NKTR-181 across 12 weeks in opioid-naïve subjects with chronic low back pain. SUMMIT-LTS was a 52 week open-label study in opioid-naïve and experienced subjects with chronic low back pain or noncancer pain rolled over from SUMMIT-07 or enrolled <i>de novo</i>. System evaluations were triggered by adverse events of interest and drug accountability discrepancies signaling potentially abuse-related events. Each event was assigned a primary classification and supplementary classification(s) by investigators and by a blinded, independent committee of substance abuse experts (adjudicators). At the final study visit, investigators administered a survey to subjects to identify overlooked events of interest. <b>Results:</b> Seventy-nine (6.6%) of 1189 subjects were associated with 86 events in SUMMIT-07 and 51 (8.0%) of 638 subjects were associated with 59 events in SUMMIT-LTS. Most events were attributed to “Withdrawal” and, primarily in SUMMIT-07, “Therapeutic Error” (unintentional overuse) or “Misuse” (intentional overuse for a therapeutic purpose) of study medication. Adjudicators identified five possible “Abuse” events (three NKTR-181, two placebo) in SUMMIT-07 and four possible “Abuse” events (all NKTR-181) in SUMMIT-LTS. <b>Conclusions:</b> The MADDERS® system discerns potentially abuse-related events and identified low rates of withdrawal and a low risk of abuse potential, diversion or addiction associated with NKTR-181 in phase 3 trials.
DOI: 10.6084/m9.figshare.7931738.v1
title: Assessment of potentially abuse-related events in two phase 3 studies of NKTR-181, a novel opioid analgesic, using the MADDERS® system (Misuse, Abuse, and Diversion Drug Event Reporting System)

description: <b>Objective:</b> To prospectively evaluate the abuse potential of NKTR-181, a novel opioid analgesic, in two phase 3 clinical trials using a newly developed reporting system: the Misuse, Abuse, and Diversion Drug Event Reporting System (MADDERS®). <b>Methods:</b> SUMMIT-07 was an enriched enrollment randomized withdrawal study that examined the safety and efficacy of NKTR-181 across 12 weeks in opioid-naïve subjects with chronic low back pain. SUMMIT-LTS was a 52 week open-label study in opioid-naïve and experienced subjects with chronic low back pain or noncancer pain rolled over from SUMMIT-07 or enrolled <i>de novo</i>. System evaluations were triggered by adverse events of interest and drug accountability discrepancies signaling potentially abuse-related events. Each event was assigned a primary classification and supplementary classification(s) by investigators and by a blinded, independent committee of substance abuse experts (adjudicators). At the final study visit, investigators administered a survey to subjects to identify overlooked events of interest. <b>Results:</b> Seventy-nine (6.6%) of 1189 subjects were associated with 86 events in SUMMIT-07 and 51 (8.0%) of 638 subjects were associated with 59 events in SUMMIT-LTS. Most events were attributed to “Withdrawal” and, primarily in SUMMIT-07, “Therapeutic Error” (unintentional overuse) or “Misuse” (intentional overuse for a therapeutic purpose) of study medication. Adjudicators identified five possible “Abuse” events (three NKTR-181, two placebo) in SUMMIT-07 and four possible “Abuse” events (all NKTR-181) in SUMMIT-LTS. <b>Conclusions:</b> The MADDERS® system discerns potentially abuse-related events and identified low rates of withdrawal and a low risk of abuse potential, diversion or addiction associated with NKTR-181 in phase 3 trials.
DOI: 10.6084/m9.figshare.25415206
title: Road Surface Type Dataset of Kenya

description: Road Surface Type Dataset of Kenya