cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.7506293
title: Knowledge assessment of dentistry undergraduate students and dentists in the city of Aracaju/ Sergipe regarding the appropriate use of antimicrobial drugs

description: INTRODUCTION:Antimicrobial agents are a striking example of the evolution of modern medicine. However the adaptability of microorganisms provides resistance to certain antimicrobial drugs.OBJECTIVE:To assess the knowledge of dentistry undergraduate students and dentists in the city of Aracaju, Sergipe State, about antibiotic therapy, thus providing an opportunity to identify and recognize the risks related to improper administration of these drugs.MATERIAL AND METHOD:This is an observational, cross sectional study based on a questionnaire given to 80 undergraduate students of dentistry and 50 dentists, ramdomly chosen, to assess the knowledge on the matter.RESULT: Among the interviewees, about 40% were dentists and 60% were dentistry students, 40% of respondents reported to prescribe antimicrobials using as selection criteria that it be selective and bactericidal, and 90% of respondents said they prescribe antibiotics only when necessary, in order to avoid bacterial resistance.CONCLUSION: According to the methodology applied it can be concluded that both groups showed lack of knowledge about the difference between antibiotic therapy, antimicrobial prophylaxis and drug therapy.
DOI: 10.6084/m9.figshare.7511030
title: Normative changes, socio-legal shifts: analyzing the efficacy of the Inter-American Court of Human Rights

description: Abstract This article aims to analyse the development of Legislative Change into a reparation measure, taking into consideration its use by the Inter-American Court of Human Rights. The study will propose a categorization of decisions based on the legal questions raised by the Court’s orders for legislative change. Subsequently, it will examine the effects of each such order upon the domestic legal system with the purpose of assessing the efficacy of this reparatory measure.
DOI: 10.6084/m9.figshare.7511030.v1
title: Normative changes, socio-legal shifts: analyzing the efficacy of the Inter-American Court of Human Rights

description: Abstract This article aims to analyse the development of Legislative Change into a reparation measure, taking into consideration its use by the Inter-American Court of Human Rights. The study will propose a categorization of decisions based on the legal questions raised by the Court’s orders for legislative change. Subsequently, it will examine the effects of each such order upon the domestic legal system with the purpose of assessing the efficacy of this reparatory measure.
DOI: 10.6084/m9.figshare.7515851
title: Management of gestational hypothyroidism: results of a Brazilian survey

description: Objectives Evaluate the management of hypothyroidism in fertile-aged and pregnant women and compare these practices to the recommendations of the Brazilian Society of Endocrinology and Metabolism (SBEM) and the Latin American Thyroid Society, published in 2013. Materials and methods In the first trimester of 2014, SBEM made available to all members an electronic questionnaire based on clinical scenarios in the management of gestational hypothyroidism. The responses of 406 physicians, most of them endocrinologists, were analyzed. Results Eighty-one per cent of the endocrinologists screen all their pregnant patients for thyroid dysfunction, mostly during the pregestational period or after the first prenatal visit. Following screening, 82% of the respondents initiate treatment when TSH levels are &gt; 2.5 mIU/L while 67% monitor their pregnant patients even if TSH was normal on first trimester screening. For hypothyroid women who are planning pregnancy, 96% of the clinicians are aware of the importance of adjusting the levothyroxine (LT4) dose as soon as pregnancy is confirmed. However, opinions diverge with respect to adjusting the LT4 dose before or after reassessing thyroid function. The most widely used tests for monitoring pregnant women in use of LT4 are TSH and free T4 (62%) or TSH alone (21%). Unanimously, the treatment goal is to achieve the target TSH level for each trimester of gestation. Conclusion The recommendations of the consensus statements are incorporated into the respondents’ clinical practice. It is noteworthy that the great majority of the clinicians favor universal screening.
DOI: 10.6084/m9.figshare.7515851.v1
title: Management of gestational hypothyroidism: results of a Brazilian survey

description: Objectives Evaluate the management of hypothyroidism in fertile-aged and pregnant women and compare these practices to the recommendations of the Brazilian Society of Endocrinology and Metabolism (SBEM) and the Latin American Thyroid Society, published in 2013. Materials and methods In the first trimester of 2014, SBEM made available to all members an electronic questionnaire based on clinical scenarios in the management of gestational hypothyroidism. The responses of 406 physicians, most of them endocrinologists, were analyzed. Results Eighty-one per cent of the endocrinologists screen all their pregnant patients for thyroid dysfunction, mostly during the pregestational period or after the first prenatal visit. Following screening, 82% of the respondents initiate treatment when TSH levels are &gt; 2.5 mIU/L while 67% monitor their pregnant patients even if TSH was normal on first trimester screening. For hypothyroid women who are planning pregnancy, 96% of the clinicians are aware of the importance of adjusting the levothyroxine (LT4) dose as soon as pregnancy is confirmed. However, opinions diverge with respect to adjusting the LT4 dose before or after reassessing thyroid function. The most widely used tests for monitoring pregnant women in use of LT4 are TSH and free T4 (62%) or TSH alone (21%). Unanimously, the treatment goal is to achieve the target TSH level for each trimester of gestation. Conclusion The recommendations of the consensus statements are incorporated into the respondents’ clinical practice. It is noteworthy that the great majority of the clinicians favor universal screening.
DOI: 10.6084/m9.figshare.7518806.v1
title: Puberty beginning in lambs from hairless ewe submitted to caloric or protein restriction

description: AbstractThis study was carried out to evaluate if caloric or protein restriction in lactation ewe affect puberty beginning of its lambs. Had been used 21 lambs, two females and five males per type of treatment. During 60 days the mothers received the treatment for which its lamb was sort out: Control Treatment (TC, maintenance), Energy Restriction Treatment (TRC, ½ of the energy of the TC) and Protein Restriction Treatment (TRP, 1/3 of the protein of the TC). The lambs were weaned and received a diet composed by corn silage and concentrate, weighed and evaluated fortnightly. In males, the ejaculate was collected, scrotal circumference and testicular size measured. In females, it was realized ultrasound to measure the ovaries and verify the corpus luteum presence. For males was considered in puberty if produced ejaculation with at least: motility of 50%, sperm concentration of 50 x 106espermatozoa/mL and maximum of 50% total sperm abnormalities, and females if exhibit corpus luteum. An interaction was found between evaluation period and treatment for scrotum circumference (p=0.0019), testicular volume (p=0.0025) sperm motility (p&lt;0.0001) and concentration (p=0.027), TRP was later than TRC and TC in all variable. In female no treatment effect (p&gt;0.05) were found about follicles characteristics, however that was difference in the presence of corpous luteum (p=0.0179). The TC females showed corpus luteum from the 10th week, TRC 11th and 13th for TRP. It was concluded that mother protein restriction during the lactation delays the beginning of the puberty of its lambs.
DOI: 10.6084/m9.figshare.7835342
title: Relationship between inflammatory markers, glycated hemoglobin and placental weight on fetal outcomes in women with gestational diabetes

description: ABSTRACT Objective: The aim of this study was to evaluate the relationship between inflammatory cytokines, placental weight, glycated hemoglobin and adverse perinatal outcomes (APOs) in women with gestational diabetes mellitus (GDM). Subjects and methods: This was a prospective, longitudinal and observational study conducted from April 2004 to November 2005 in Bauru, Brazil. Included patients had singleton pregnancies and performed a 100 g OGTT and had the levels of C-reactive protein (CRP), interleukin (IL)-6, TNF alfa and glycated hemoglobin (HbA1c) determined at 24-28th gestation weeks. Results: A total of 176 patients were included, of whom 78 had the diagnosis of GDM (44.3%). Multivariate analysis demonstrated that HbA1c, age, body mass index (BMI) and previous history of GDM were independent predictors for GDM diagnosis. ROC curve indicated that HbA1C levels ≥ 5.1% at 24-28 weeks gestation were associated with GDM. No difference was found in IL-6, tumor necrosis factor alpha (TNF-alpha) and CRP serum levels in women with and without GDM. Multivariate analysis showed that placental weight was significantly associated with APOs (p &lt; 0.005), with a cut-off value of 610 grams as demonstrated by the ROC curve. Conclusion: Placental weight ≥ 610 grams and HbA1C ≥ 5.1% were found to be associated with APOs and GDM, respectively, and their evaluation should be part of prenatal care routine.
DOI: 10.6084/m9.figshare.11267828
title: THE ROLE OF INTERSEMITIC TRANSLATION FOR SERIES LEGENDING: ANALYZING LIKE LADY VIOLET SPEAKERS IN DOWNTON ABBEY 1T

description: Abstract To contribute to the subtitling practices, this paper presents part of a research that was carried out in the Programa de Pós-Graduação em Linguagem e Ensino of the Universidade Federal de Campina Grande. The study analyzes the influence of Intersemiotic Translation on the subtitling of Lady Violet Crawley’s lines in Downton Abbey. As theoretical reference, we use discussions about Intersemiotic Translation by Plaza (2013), Jakobson (2000) and Frías (2011); of Semiotics by Pignatari (2004) and Pierce (2005); of subtitling by Georgakopoulou (2009), Betz (2009) and Skuggevik (2009); as well as studies on facial expressions by Ekman and Friesen (2003) and Darwin (1872), among others. This study is part of Multimedia Translation Studies (Williams; Chesterman, 2002), and it is product-oriented. Results indicate that Intersemiotic Translation generates subtitles that are influenced, compensated and/or complemented by the non-verbal elements of the film and derivates subtitling strategies that respect the semiotic framework of the audiovisual piece.
DOI: 10.6084/m9.figshare.11267828.v1
title: THE ROLE OF INTERSEMITIC TRANSLATION FOR SERIES LEGENDING: ANALYZING LIKE LADY VIOLET SPEAKERS IN DOWNTON ABBEY 1T

description: Abstract To contribute to the subtitling practices, this paper presents part of a research that was carried out in the Programa de Pós-Graduação em Linguagem e Ensino of the Universidade Federal de Campina Grande. The study analyzes the influence of Intersemiotic Translation on the subtitling of Lady Violet Crawley’s lines in Downton Abbey. As theoretical reference, we use discussions about Intersemiotic Translation by Plaza (2013), Jakobson (2000) and Frías (2011); of Semiotics by Pignatari (2004) and Pierce (2005); of subtitling by Georgakopoulou (2009), Betz (2009) and Skuggevik (2009); as well as studies on facial expressions by Ekman and Friesen (2003) and Darwin (1872), among others. This study is part of Multimedia Translation Studies (Williams; Chesterman, 2002), and it is product-oriented. Results indicate that Intersemiotic Translation generates subtitles that are influenced, compensated and/or complemented by the non-verbal elements of the film and derivates subtitling strategies that respect the semiotic framework of the audiovisual piece.
DOI: 10.6084/m9.figshare.7835342.v1
title: Relationship between inflammatory markers, glycated hemoglobin and placental weight on fetal outcomes in women with gestational diabetes

description: ABSTRACT Objective: The aim of this study was to evaluate the relationship between inflammatory cytokines, placental weight, glycated hemoglobin and adverse perinatal outcomes (APOs) in women with gestational diabetes mellitus (GDM). Subjects and methods: This was a prospective, longitudinal and observational study conducted from April 2004 to November 2005 in Bauru, Brazil. Included patients had singleton pregnancies and performed a 100 g OGTT and had the levels of C-reactive protein (CRP), interleukin (IL)-6, TNF alfa and glycated hemoglobin (HbA1c) determined at 24-28th gestation weeks. Results: A total of 176 patients were included, of whom 78 had the diagnosis of GDM (44.3%). Multivariate analysis demonstrated that HbA1c, age, body mass index (BMI) and previous history of GDM were independent predictors for GDM diagnosis. ROC curve indicated that HbA1C levels ≥ 5.1% at 24-28 weeks gestation were associated with GDM. No difference was found in IL-6, tumor necrosis factor alpha (TNF-alpha) and CRP serum levels in women with and without GDM. Multivariate analysis showed that placental weight was significantly associated with APOs (p &lt; 0.005), with a cut-off value of 610 grams as demonstrated by the ROC curve. Conclusion: Placental weight ≥ 610 grams and HbA1C ≥ 5.1% were found to be associated with APOs and GDM, respectively, and their evaluation should be part of prenatal care routine.
DOI: 10.6084/m9.figshare.11452338
title: Ways and Voices of the Affect

description: Abstract Ways and Voices of the AffectThe article analyses the different treatments of affect in the field of semiotic researches opened by Greimas. It highlights the premises, their developments, their disappearances and their resurgences, and more generally the complementarities and solidary derivations. In Sémantique Structurale, Greimas already posed some milestones with the thymic category and proprioceptivity. Much later, the theory of passions will encounter tensiveness, and Claude Zilberberg will even make affect the point of origin of all tensiveness. Then arrives the contribution of Eric Landowski, who, under the heading of “feeling” (l’éprouver), renders obsolete the distinction between lexicalized passions (nameable) and “passions without names”. The proposals of Jacques Geninasca, Herman Parret and more recently Waldir Beividas will also be evoked. But above all we shall insist on the path developed by Greimas himself in De l’Imperfection, starting from the esthetic experience in existence itself.
DOI: 10.6084/m9.figshare.7507271
title: Six-week anaerobic training improves proteolytic profile of diabetic rats

description: Objective To evaluate the effect of six-week anaerobic training on the mRNA expression of genes related to proteolysis Ubb (Ubiquitin), E2-14kDa, Trim63 (MuRF1 protein) and Nfkb1 in the skeletal muscle of diabetic rats.Materials and methods Four groups were established: DE (DiabetesExercised), DS (Diabetes Sedentary), CE (Control Exercised) and CS (Control Sedentary). The training consisted of 3 sets of 12 jumps in the liquid mean with load equivalent to 50% of BW for 6 weeks. Euthanasia occurred under ip anesthesia, and blood, adipose tissue and skeletal muscles were collected. Gene expression was quantified by RT–PCR in the gastrocnemius muscle. ANOVA one-way was used for comparison among groups, with post-hoc (Tukey) when necessary, considering p &lt; 0.05.Results We observed reduction in the body weight and adipose tissue in the diabetic groups. The muscle mass was reduced in DS, which could be reversed by training (DE). Although DS and DE have presented similar body weight, the training protocol in DE promoted reduction in the adipose tissue, and increase of muscle mass. Anaerobic training was efficient to reduce glycaemia only in the diabetic animals until 6 hours after the end of training. The Trim63 gene expression was increased in DS; decreased Ubb gene level was observed in trained rats (CE and DE) compared to sedentary (CS and DS), and DE presented the lowest level of E2-14kDa gene expression.Conclusion Six-week anaerobic training promoted muscle mass gain, improved glycemic control, and exerted inhibitory effect on the proteolysis of gastrocnemius muscle of diabetic rats.
DOI: 10.6084/m9.figshare.7506293.v1
title: Knowledge assessment of dentistry undergraduate students and dentists in the city of Aracaju/ Sergipe regarding the appropriate use of antimicrobial drugs

description: INTRODUCTION:Antimicrobial agents are a striking example of the evolution of modern medicine. However the adaptability of microorganisms provides resistance to certain antimicrobial drugs.OBJECTIVE:To assess the knowledge of dentistry undergraduate students and dentists in the city of Aracaju, Sergipe State, about antibiotic therapy, thus providing an opportunity to identify and recognize the risks related to improper administration of these drugs.MATERIAL AND METHOD:This is an observational, cross sectional study based on a questionnaire given to 80 undergraduate students of dentistry and 50 dentists, ramdomly chosen, to assess the knowledge on the matter.RESULT: Among the interviewees, about 40% were dentists and 60% were dentistry students, 40% of respondents reported to prescribe antimicrobials using as selection criteria that it be selective and bactericidal, and 90% of respondents said they prescribe antibiotics only when necessary, in order to avoid bacterial resistance.CONCLUSION: According to the methodology applied it can be concluded that both groups showed lack of knowledge about the difference between antibiotic therapy, antimicrobial prophylaxis and drug therapy.
DOI: 10.6084/m9.figshare.7507271.v1
title: Six-week anaerobic training improves proteolytic profile of diabetic rats

description: Objective To evaluate the effect of six-week anaerobic training on the mRNA expression of genes related to proteolysis Ubb (Ubiquitin), E2-14kDa, Trim63 (MuRF1 protein) and Nfkb1 in the skeletal muscle of diabetic rats.Materials and methods Four groups were established: DE (DiabetesExercised), DS (Diabetes Sedentary), CE (Control Exercised) and CS (Control Sedentary). The training consisted of 3 sets of 12 jumps in the liquid mean with load equivalent to 50% of BW for 6 weeks. Euthanasia occurred under ip anesthesia, and blood, adipose tissue and skeletal muscles were collected. Gene expression was quantified by RT–PCR in the gastrocnemius muscle. ANOVA one-way was used for comparison among groups, with post-hoc (Tukey) when necessary, considering p &lt; 0.05.Results We observed reduction in the body weight and adipose tissue in the diabetic groups. The muscle mass was reduced in DS, which could be reversed by training (DE). Although DS and DE have presented similar body weight, the training protocol in DE promoted reduction in the adipose tissue, and increase of muscle mass. Anaerobic training was efficient to reduce glycaemia only in the diabetic animals until 6 hours after the end of training. The Trim63 gene expression was increased in DS; decreased Ubb gene level was observed in trained rats (CE and DE) compared to sedentary (CS and DS), and DE presented the lowest level of E2-14kDa gene expression.Conclusion Six-week anaerobic training promoted muscle mass gain, improved glycemic control, and exerted inhibitory effect on the proteolysis of gastrocnemius muscle of diabetic rats.
DOI: 10.6084/m9.figshare.7507799.v1
title: Prevalence and reasons for refusal to participate in clinical research

description: Abstract The information provided regarding the prevalence and reasons why volunteers refuse to participate in scientific research is sparse. This article aims to describe the prevalence and reasons for refusing to voluntarily participate in the cohort study whose objective is to evaluate morbidity and mortality amongst people living with HIV/AIDS (PLWHA), through a cross-sectional study conducted at the Centro de Treinamento e Referência em Doenças Infecciosas e Parasitárias (Training and Referral Center for Infectious and Parasitic Diseases). The following information was obtained: origin, date of birth, age, gender, and reason for not consenting, when applicable. The lack of time to devote to the research was the main reason given (63%), followed by fear of lack of confidentiality (17%). There was no statistical difference among those who accepted or not to participate in terms of gender, age or origin of the service. The percentage of PLWHA who refused to participate in the study (40.7%) and lack of time available for their participation (63%) were considered high.
DOI: 10.6084/m9.figshare.7507799
title: Prevalence and reasons for refusal to participate in clinical research

description: Abstract The information provided regarding the prevalence and reasons why volunteers refuse to participate in scientific research is sparse. This article aims to describe the prevalence and reasons for refusing to voluntarily participate in the cohort study whose objective is to evaluate morbidity and mortality amongst people living with HIV/AIDS (PLWHA), through a cross-sectional study conducted at the Centro de Treinamento e Referência em Doenças Infecciosas e Parasitárias (Training and Referral Center for Infectious and Parasitic Diseases). The following information was obtained: origin, date of birth, age, gender, and reason for not consenting, when applicable. The lack of time to devote to the research was the main reason given (63%), followed by fear of lack of confidentiality (17%). There was no statistical difference among those who accepted or not to participate in terms of gender, age or origin of the service. The percentage of PLWHA who refused to participate in the study (40.7%) and lack of time available for their participation (63%) were considered high.
DOI: 10.6084/m9.figshare.7511171
title: Peripheral device to quantify grip and pinch capacity of children

description: Abstract Introduction Grip and pinch movements are important to perform daily activities and to manipulate objects. In this paper we describe the development and evaluation of a peripheral device to quantify cylindrical grip, pulp-to-pulp pinch, pulp-to-side pinch strength and range of motion of children. Methods Three objects were selected: a door handle, a switch, and a key, which were instrumented with force sensing resistors to analyse the strength. Potentiometers were used to verify the range of motion and micro switches to assure the correct position of the fingers during the movement execution. Thirty volunteers (8.77 ± 1.28), both male and female, were selected to test the peripheral device functionality. Results The results determined the minimum necessary strength values for the object activation and maximum displacement, in which the values are 2.5N, 40°; 2.7N, 55°; and 2.8N, 100%, for door handle object, key object, and switch object, respectively. In the functionally tests, volunteers have shown a superior strength for activating each object and 73.33% of them have completed the range movement in the key object, 86.67% in the switch object, and 93.33% in the door handle object. Conclusion The developed peripheral device enabled the measurement of range and static and dynamic strength of grip and pinch movements of children.