cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.25345/c5rn30j9j
title: MassIVE MSV000093973 - GnRH Induces Citrullination of the Cytoskeleton in Murine Gonadotrope Cells
title: Abstract: Peptidylarginine deiminases (PADs or PADIs) catalyze the conversion of positively charged arginine to neutral citrulline, which alters target protein structure and function. It is well established that a gonadotropin releasing hormone agonist (GnRHa) stimulates PAD2-catalyzed histone citrullination to epigenetically regulate gonadotropin gene expression in the gonadotrope derived LBT2 cell line. However, PADs are also found in the cytoplasm. Given this, we used mass spectrometry to identify additional non-histone proteins that are citrullinated following GnRHa stimulation and characterize the temporal dynamics of this modification. Our results show that actin and tubulin are rapidly citrullinated, which led us to hypothesize that GnRHa might induce their citrullination to modulate cytoskeletal dynamics and architecture. Data shows that 10 nM GnRHa induces citrullination of beta-actin with maximal levels occurring at 10 minutes. The level of beta-actin citrullination is reduced in the presence of the pan-PAD inhibitor bi-phenyl-benzimidazole-Cl-amidine (BB-ClA), which also prevents GnRHa induced actin reorganization in dispersed mouse gonadotrope cells. GnRHa induces citrullination of beta-tubulin with elevated levels occurring at 30 minutes; similarly to beta-actin, this response is attenuated in the presence of BB-ClA. To examine the functional consequence of beta-tubulin citrullination, we utilized fluorescently tagged end binding protein 1 (EB1-GFP) to track the growing plus end of microtubules (MT) in real time in transfected LBT2 cells. Time-lapse confocal microscopy of EB1-GFP reveals that MT average lifetime increases following 30 minutes of GnRHa treatment, but this increase is attenuated by PAD inhibition. Taken together, our data suggest that GnRHa induced citrullination alters actin reorganization and MT lifetime in gonadotrope cells. Keywords: gonadotrope, peptidylarginine deiminase, citrullination, cytoskeleton, beta tubulin, beta actin, microtubules
DOI: 10.7925/drs1.duchas_4728726
title: Care of Our Farm Animals

description: Story collected by Michael Mc Gillicuddy, a student at Oileán Ciarraí school (Castleisland, Co. Kerry) from informant Mrs Mary Mc Gillicuddy.
description: Collected as part of the Schools' Folklore scheme, 1937-1938, under the supervision of teacher Tadhg Ó Céin.
description: Supported by funding from the Department of Arts, Heritage and the Gaeltacht (Ireland), University College Dublin, and the National Folklore Foundation (Fondúireacht Bhéaloideas Éireann), 2014-2016.
DOI: 10.7925/drs1.duchas_5201045
title: Páircainmneacha

description: Story collected by Kevin Moore, a student at Meelick (B.) school (Meelick, Co. Clare) (no informant identified).
description: Collected as part of the Schools' Folklore scheme, 1937-1938, under the supervision of teacher Eoghan Ó Néill.
description: Supported by funding from the Department of Arts, Heritage and the Gaeltacht (Ireland), University College Dublin, and the National Folklore Foundation (Fondúireacht Bhéaloideas Éireann), 2014-2016.
DOI: 10.7925/drs1.duchas_4514914
title: Scálán

description: Story collected by Ailbhe Ó Conáin, a student at Baile na Bó school (Ballyboe, Co. Donegal) from informant an tAthair Ua Frigil.
description: Collected as part of the Schools' Folklore scheme, 1937-1938, under the supervision of teacher Ailbhe Ó Conáin.
description: Supported by funding from the Department of Arts, Heritage and the Gaeltacht (Ireland), University College Dublin, and the National Folklore Foundation (Fondúireacht Bhéaloideas Éireann), 2014-2016.
DOI: 10.7925/drs1.duchas_4728727
title: Young Smith of the Tricks

description: Story collected by Nellie Doyle, a student at Ballyseedy school (Ballyseedy, Co. Kerry) from informant Nóra Ní Shuilleabháin.
description: Collected as part of the Schools' Folklore scheme, 1937-1938, under the supervision of teacher Prionsias Ní Thíodhcháin.
description: Supported by funding from the Department of Arts, Heritage and the Gaeltacht (Ireland), University College Dublin, and the National Folklore Foundation (Fondúireacht Bhéaloideas Éireann), 2014-2016.
DOI: 10.7925/drs1.duchas_5201047
title: Proverbs

description: Story collected by Class, a student at Tamhnach, Inis school (Toonagh, Co. Clare) (no informant identified).
description: Collected as part of the Schools' Folklore scheme, 1937-1938, under the supervision of teacher Proinnsias Gordún.
description: Supported by funding from the Department of Arts, Heritage and the Gaeltacht (Ireland), University College Dublin, and the National Folklore Foundation (Fondúireacht Bhéaloideas Éireann), 2014-2016.
DOI: 10.7925/drs1.duchas_4514915
title: Ard na Teamhrach

description: Story collected by Siubhan Ní Dhochartaigh, a student at Cruit Island school (Cruit Island, Co. Donegal) from informant Aodh Ó Dhochartaigh.
description: Collected as part of the Schools' Folklore scheme, 1937-1938, under the supervision of teacher Pádraig Ó Domhnaill.
description: Supported by funding from the Department of Arts, Heritage and the Gaeltacht (Ireland), University College Dublin, and the National Folklore Foundation (Fondúireacht Bhéaloideas Éireann), 2014-2016.
DOI: 10.7925/drs1.duchas_4728728
title: Care of Our Farm Animals

description: Story collected by Neilly Mitchel, a student at Oileán Ciarraí school (Castleisland, Co. Kerry) from informant John Lynch.
description: Collected as part of the Schools' Folklore scheme, 1937-1938, under the supervision of teacher Tadhg Ó Céin.
description: Supported by funding from the Department of Arts, Heritage and the Gaeltacht (Ireland), University College Dublin, and the National Folklore Foundation (Fondúireacht Bhéaloideas Éireann), 2014-2016.
DOI: 10.7925/drs1.duchas_5201048
title: Stories of Gold

description: Story collected by William Jones, a student at Currakyle, Feakle school (Corrakyle, Co. Clare) from informant Mrs T. Jones.
description: Collected as part of the Schools' Folklore scheme, 1937-1938, under the supervision of teacher Bean Uí Innseadúin.
description: Supported by funding from the Department of Arts, Heritage and the Gaeltacht (Ireland), University College Dublin, and the National Folklore Foundation (Fondúireacht Bhéaloideas Éireann), 2014-2016.
DOI: 10.7925/drs1.duchas_4728729
title: Ghost of Gleannscoheen

description: Story collected by Thomas Higgins, a student at Ballyseedy school (Ballyseedy, Co. Kerry) from informant an unidentified informant.
description: Collected as part of the Schools' Folklore scheme, 1937-1938, under the supervision of teacher Prionsias Ní Thíodhcháin.
description: Supported by funding from the Department of Arts, Heritage and the Gaeltacht (Ireland), University College Dublin, and the National Folklore Foundation (Fondúireacht Bhéaloideas Éireann), 2014-2016.
DOI: 10.7925/drs1.duchas_5201049
title: Nicknames

description: Story collected by Class, a student at Tamhnach, Inis school (Toonagh, Co. Clare) (no informant identified).
description: Collected as part of the Schools' Folklore scheme, 1937-1938, under the supervision of teacher Proinnsias Gordún.
description: Supported by funding from the Department of Arts, Heritage and the Gaeltacht (Ireland), University College Dublin, and the National Folklore Foundation (Fondúireacht Bhéaloideas Éireann), 2014-2016.
DOI: 10.7925/drs1.duchas_4514916
title: Gentle Places

description: Story collected by Ellen Doohan, a student at Losad school (Losset, Co. Donegal) from informant John Connaghan.
description: Collected as part of the Schools' Folklore scheme, 1937-1938, under the supervision of teacher Úna Bean Uí Laoghaire.
description: Supported by funding from the Department of Arts, Heritage and the Gaeltacht (Ireland), University College Dublin, and the National Folklore Foundation (Fondúireacht Bhéaloideas Éireann), 2014-2016.
DOI: 10.7925/drs1.duchas_5201051
title: Riddles

description: Story collected by a student at Tamhnach, Inis school (Toonagh, Co. Clare) (no informant identified).
description: Collected as part of the Schools' Folklore scheme, 1937-1938, under the supervision of teacher Proinnsias Gordún.
description: Supported by funding from the Department of Arts, Heritage and the Gaeltacht (Ireland), University College Dublin, and the National Folklore Foundation (Fondúireacht Bhéaloideas Éireann), 2014-2016.
DOI: 10.7925/drs1.duchas_4514917
title: Uaigh an Mhairnéalaigh

description: Story collected by Máire Ní Dhochartaigh, a student at Cruit Island school (Cruit Island, Co. Donegal) from informant Aodh Ó Dhochartaigh.
description: Collected as part of the Schools' Folklore scheme, 1937-1938, under the supervision of teacher Pádraig Ó Domhnaill.
description: Supported by funding from the Department of Arts, Heritage and the Gaeltacht (Ireland), University College Dublin, and the National Folklore Foundation (Fondúireacht Bhéaloideas Éireann), 2014-2016.
DOI: 10.7925/drs1.duchas_4728730
title: Care of Our Farm Animals

description: Story collected by James O' Sullivan, a student at Oileán Ciarraí school (Castleisland, Co. Kerry) from informant John Lynch.
description: Collected as part of the Schools' Folklore scheme, 1937-1938, under the supervision of teacher Tadhg Ó Céin.
description: Supported by funding from the Department of Arts, Heritage and the Gaeltacht (Ireland), University College Dublin, and the National Folklore Foundation (Fondúireacht Bhéaloideas Éireann), 2014-2016.
DOI: 10.7925/drs1.duchas_4728732
title: Local Cures

description: Story collected by Katty Neil, a student at Anabla school (Anablaha, Co. Kerry) from informant John Neil.
description: Collected as part of the Schools' Folklore scheme, 1937-1938, under the supervision of teacher Máighréad Ní Théacháin.
description: Supported by funding from the Department of Arts, Heritage and the Gaeltacht (Ireland), University College Dublin, and the National Folklore Foundation (Fondúireacht Bhéaloideas Éireann), 2014-2016.
DOI: 10.7925/drs1.duchas_4514918
title: Paidreacha

description: Story collected by Nora Ní Gallchóbhair, a student at Cruit Island school (Cruit Island, Co. Donegal) from informant Róise Ní Gallchóbhair.
description: Collected as part of the Schools' Folklore scheme, 1937-1938, under the supervision of teacher Pádraig Ó Domhnaill.
description: Supported by funding from the Department of Arts, Heritage and the Gaeltacht (Ireland), University College Dublin, and the National Folklore Foundation (Fondúireacht Bhéaloideas Éireann), 2014-2016.
DOI: 10.7925/drs1.duchas_5201052
title: Stories of Gold

description: Story collected by Brigid Hayes, a student at Currakyle, Feakle school (Corrakyle, Co. Clare) (no informant identified).
description: Collected as part of the Schools' Folklore scheme, 1937-1938, under the supervision of teacher Bean Uí Innseadúin.
description: Supported by funding from the Department of Arts, Heritage and the Gaeltacht (Ireland), University College Dublin, and the National Folklore Foundation (Fondúireacht Bhéaloideas Éireann), 2014-2016.
DOI: 10.7925/drs1.duchas_4728733
title: Historical Tradition

description: Story collected by James O' Sullivan, a student at Oileán Ciarraí school (Castleisland, Co. Kerry) from informant Mrs Mary O' Sullivan.
description: Collected as part of the Schools' Folklore scheme, 1937-1938, under the supervision of teacher Tadhg Ó Céin.
description: Supported by funding from the Department of Arts, Heritage and the Gaeltacht (Ireland), University College Dublin, and the National Folklore Foundation (Fondúireacht Bhéaloideas Éireann), 2014-2016.
DOI: 10.7925/drs1.duchas_5201054
title: Stories of Gold

description: Story collected by Maureen O' Donnell, a student at Currakyle, Feakle school (Corrakyle, Co. Clare) from informant Miss Nora Cooney.
description: Collected as part of the Schools' Folklore scheme, 1937-1938, under the supervision of teacher Bean Uí Innseadúin.
description: Supported by funding from the Department of Arts, Heritage and the Gaeltacht (Ireland), University College Dublin, and the National Folklore Foundation (Fondúireacht Bhéaloideas Éireann), 2014-2016.
DOI: 10.7925/drs1.duchas_4514919
title: Luibheanna

description: Story collected by Nora Ní Gallchóbhair, a student at Cruit Island school (Cruit Island, Co. Donegal) from informant Róise Ní Gallchóbhair.
description: Collected as part of the Schools' Folklore scheme, 1937-1938, under the supervision of teacher Pádraig Ó Domhnaill.
description: Supported by funding from the Department of Arts, Heritage and the Gaeltacht (Ireland), University College Dublin, and the National Folklore Foundation (Fondúireacht Bhéaloideas Éireann), 2014-2016.
DOI: 10.7925/drs1.duchas_4728734
title: Historical Tradition

description: Story collected by Con Houlihan, a student at Oileán Ciarraí school (Castleisland, Co. Kerry) from informant Mrs Ellen Daly.
description: Collected as part of the Schools' Folklore scheme, 1937-1938, under the supervision of teacher Tadhg Ó Céin.
description: Supported by funding from the Department of Arts, Heritage and the Gaeltacht (Ireland), University College Dublin, and the National Folklore Foundation (Fondúireacht Bhéaloideas Éireann), 2014-2016.
DOI: 10.7925/drs1.duchas_5201063
title: Páircainmneacha

description: Story collected by Patrick O Sullivan, a student at Meelick (B.) school (Meelick, Co. Clare) from informant John Doyle.
description: Collected as part of the Schools' Folklore scheme, 1937-1938, under the supervision of teacher Eoghan Ó Néill.
description: Supported by funding from the Department of Arts, Heritage and the Gaeltacht (Ireland), University College Dublin, and the National Folklore Foundation (Fondúireacht Bhéaloideas Éireann), 2014-2016.
DOI: 10.7925/drs1.duchas_4514920
title: Haunted Places

description: Story collected by Nuala Doherty, a student at Losad school (Losset, Co. Donegal) from informant James Doherty.
description: Collected as part of the Schools' Folklore scheme, 1937-1938, under the supervision of teacher Úna Bean Uí Laoghaire.
description: Supported by funding from the Department of Arts, Heritage and the Gaeltacht (Ireland), University College Dublin, and the National Folklore Foundation (Fondúireacht Bhéaloideas Éireann), 2014-2016.
DOI: 10.7925/drs1.duchas_5201067
title: Carraigainmneacha

description: Story collected by Patrick O Sullivan, a student at Meelick (B.) school (Meelick, Co. Clare) from informant John Doyle.
description: Collected as part of the Schools' Folklore scheme, 1937-1938, under the supervision of teacher Eoghan Ó Néill.
description: Supported by funding from the Department of Arts, Heritage and the Gaeltacht (Ireland), University College Dublin, and the National Folklore Foundation (Fondúireacht Bhéaloideas Éireann), 2014-2016.
DOI: 10.7925/drs1.duchas_4728736
title: Historical Tradition

description: Story collected by Neilly Mitchel, a student at Oileán Ciarraí school (Castleisland, Co. Kerry) from informant John Lynch.
description: Collected as part of the Schools' Folklore scheme, 1937-1938, under the supervision of teacher Tadhg Ó Céin.
description: Supported by funding from the Department of Arts, Heritage and the Gaeltacht (Ireland), University College Dublin, and the National Folklore Foundation (Fondúireacht Bhéaloideas Éireann), 2014-2016.
DOI: 10.7925/drs1.duchas_4514921
title: Luibheanna

description: Story collected by Gráine Ní Dhomhnaill, a student at Cruit Island school (Cruit Island, Co. Donegal) from informant Máire Ní Dhomhnaill.
description: Collected as part of the Schools' Folklore scheme, 1937-1938, under the supervision of teacher Pádraig Ó Domhnaill.
description: Supported by funding from the Department of Arts, Heritage and the Gaeltacht (Ireland), University College Dublin, and the National Folklore Foundation (Fondúireacht Bhéaloideas Éireann), 2014-2016.
DOI: 10.7925/drs1.duchas_5201075
title: Hidden Gold

description: Story collected by a student at Currakyle, Feakle school (Corrakyle, Co. Clare) from informant James Moloney.
description: Collected as part of the Schools' Folklore scheme, 1937-1938, under the supervision of teacher Bean Uí Innseadúin.
description: Supported by funding from the Department of Arts, Heritage and the Gaeltacht (Ireland), University College Dublin, and the National Folklore Foundation (Fondúireacht Bhéaloideas Éireann), 2014-2016.
DOI: 10.7925/drs1.duchas_4728738
title: Herbs

description: Story collected by Neilly Mitchel, a student at Oileán Ciarraí school (Castleisland, Co. Kerry) from informant John Lynch.
description: Collected as part of the Schools' Folklore scheme, 1937-1938, under the supervision of teacher Tadhg Ó Céin.
description: Supported by funding from the Department of Arts, Heritage and the Gaeltacht (Ireland), University College Dublin, and the National Folklore Foundation (Fondúireacht Bhéaloideas Éireann), 2014-2016.
DOI: 10.7925/drs1.duchas_4514922
title: Fairies

description: Story collected by Nuala Doherty, a student at Losad school (Losset, Co. Donegal) from informant James Doherty.
description: Collected as part of the Schools' Folklore scheme, 1937-1938, under the supervision of teacher Úna Bean Uí Laoghaire.
description: Supported by funding from the Department of Arts, Heritage and the Gaeltacht (Ireland), University College Dublin, and the National Folklore Foundation (Fondúireacht Bhéaloideas Éireann), 2014-2016.
DOI: 10.7925/drs1.duchas_5201076
title: Riddles

description: Story collected by a student at Currakyle, Feakle school (Corrakyle, Co. Clare) from informant John Hayes.
description: Collected as part of the Schools' Folklore scheme, 1937-1938, under the supervision of teacher Bean Uí Innseadúin.
description: Supported by funding from the Department of Arts, Heritage and the Gaeltacht (Ireland), University College Dublin, and the National Folklore Foundation (Fondúireacht Bhéaloideas Éireann), 2014-2016.
DOI: 10.7925/drs1.duchas_4514923
title: Teampall Ráithe

description: Story collected by Ailbhe Ó Conáin, a student at Baile na Bó school (Ballyboe, Co. Donegal) from 3 informants.
description: Collected as part of the Schools' Folklore scheme, 1937-1938, under the supervision of teacher Ailbhe Ó Conáin.
description: Supported by funding from the Department of Arts, Heritage and the Gaeltacht (Ireland), University College Dublin, and the National Folklore Foundation (Fondúireacht Bhéaloideas Éireann), 2014-2016.
DOI: 10.7925/drs1.duchas_4728739
title: My Home District

description: Story collected by Katty Neil, a student at Anabla school (Anablaha, Co. Kerry) from informant John Neil.
description: Collected as part of the Schools' Folklore scheme, 1937-1938, under the supervision of teacher Máighréad Ní Théacháin.
description: Supported by funding from the Department of Arts, Heritage and the Gaeltacht (Ireland), University College Dublin, and the National Folklore Foundation (Fondúireacht Bhéaloideas Éireann), 2014-2016.
DOI: 10.7925/drs1.duchas_4728741
title: Herbs

description: Story collected by Con Houlihan, a student at Oileán Ciarraí school (Castleisland, Co. Kerry) from informant Mrs E. Daly.
description: Collected as part of the Schools' Folklore scheme, 1937-1938, under the supervision of teacher Tadhg Ó Céin.
description: Supported by funding from the Department of Arts, Heritage and the Gaeltacht (Ireland), University College Dublin, and the National Folklore Foundation (Fondúireacht Bhéaloideas Éireann), 2014-2016.
DOI: 10.7925/drs1.duchas_4514924
title: Scéal

description: Story collected by a student at Mágh Rua (Murroe) school (Murroe, Co. Donegal) from informant Domhnall Mac an Bhaird.
description: Collected as part of the Schools' Folklore scheme, 1937-1938, under the supervision of teacher P. S. Ó Dochartaigh.
description: Supported by funding from the Department of Arts, Heritage and the Gaeltacht (Ireland), University College Dublin, and the National Folklore Foundation (Fondúireacht Bhéaloideas Éireann), 2014-2016.
DOI: 10.7925/drs1.duchas_5201078
title: Áitainmneacha

description: Story collected by Patrick Hogan, a student at Meelick (B.) school (Meelick, Co. Clare) from informant Denis Hogan.
description: Collected as part of the Schools' Folklore scheme, 1937-1938, under the supervision of teacher Eoghan Ó Néill.
description: Supported by funding from the Department of Arts, Heritage and the Gaeltacht (Ireland), University College Dublin, and the National Folklore Foundation (Fondúireacht Bhéaloideas Éireann), 2014-2016.
DOI: 10.7925/drs1.duchas_4728744
title: Herbs

description: Story collected by James O' Sullivan, a student at Oileán Ciarraí school (Castleisland, Co. Kerry) from informant Mrs Mary O' Sullivan.
description: Collected as part of the Schools' Folklore scheme, 1937-1938, under the supervision of teacher Tadhg Ó Céin.
description: Supported by funding from the Department of Arts, Heritage and the Gaeltacht (Ireland), University College Dublin, and the National Folklore Foundation (Fondúireacht Bhéaloideas Éireann), 2014-2016.
DOI: 10.7925/drs1.duchas_5201079
title: Páircainmneacha

description: Story collected by Patrick Hogan, a student at Meelick (B.) school (Meelick, Co. Clare) from informant Denis Hogan.
description: Collected as part of the Schools' Folklore scheme, 1937-1938, under the supervision of teacher Eoghan Ó Néill.
description: Supported by funding from the Department of Arts, Heritage and the Gaeltacht (Ireland), University College Dublin, and the National Folklore Foundation (Fondúireacht Bhéaloideas Éireann), 2014-2016.
DOI: 10.7925/drs1.duchas_4514925
title: Haunted Places

description: Story collected by Nuala Doherty, a student at Losad school (Losset, Co. Donegal) from informant James Doherty.
description: Collected as part of the Schools' Folklore scheme, 1937-1938, under the supervision of teacher Úna Bean Uí Laoghaire.
description: Supported by funding from the Department of Arts, Heritage and the Gaeltacht (Ireland), University College Dublin, and the National Folklore Foundation (Fondúireacht Bhéaloideas Éireann), 2014-2016.
DOI: 10.7925/drs1.duchas_4728746
title: Greedy Girl

description: Story collected by Joan Sugrue, a student at Ballyseedy school (Ballyseedy, Co. Kerry) from informant Denis Sugrue.
description: Collected as part of the Schools' Folklore scheme, 1937-1938, under the supervision of teacher Prionsias Ní Thíodhcháin.
description: Supported by funding from the Department of Arts, Heritage and the Gaeltacht (Ireland), University College Dublin, and the National Folklore Foundation (Fondúireacht Bhéaloideas Éireann), 2014-2016.
DOI: 10.7925/drs1.duchas_4514926
title: Story about Colmcille

description: Story collected by John Doherty, a student at Losad school (Losset, Co. Donegal) from informant James Doherty.
description: Collected as part of the Schools' Folklore scheme, 1937-1938, under the supervision of teacher Úna Bean Uí Laoghaire.
description: Supported by funding from the Department of Arts, Heritage and the Gaeltacht (Ireland), University College Dublin, and the National Folklore Foundation (Fondúireacht Bhéaloideas Éireann), 2014-2016.
DOI: 10.7925/drs1.duchas_5201081
title: Riddles

description: Story collected by Mary Nugent, a student at Currakyle, Feakle school (Corrakyle, Co. Clare) from informant Mrs Nugent.
description: Collected as part of the Schools' Folklore scheme, 1937-1938, under the supervision of teacher Bean Uí Innseadúin.
description: Supported by funding from the Department of Arts, Heritage and the Gaeltacht (Ireland), University College Dublin, and the National Folklore Foundation (Fondúireacht Bhéaloideas Éireann), 2014-2016.
DOI: 10.7925/drs1.duchas_4728748
title: Churning

description: Story collected by Michael Mc Gillicuddy, a student at Oileán Ciarraí school (Castleisland, Co. Kerry) from informant Mrs Mary Mc Gillicuddy.
description: Collected as part of the Schools' Folklore scheme, 1937-1938, under the supervision of teacher Tadhg Ó Céin.
description: Supported by funding from the Department of Arts, Heritage and the Gaeltacht (Ireland), University College Dublin, and the National Folklore Foundation (Fondúireacht Bhéaloideas Éireann), 2014-2016.