cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.22785336
title: Surgical Treatment of Constrictive Pericarditis

description: ABSTRACT Introduction: The mainstay of the treatment of constrictive pericarditis is pericardiectomy. However, surgery is associated with high early morbidity and mortality and low long-term survival. The aim of this study is to describe our series of pericardiectomies performed over 30 years. Methods: A descriptive, observational, and retrospective analysis of all pericardiectomies performed at the Institute of Cardiology and Cardiovascular Surgery of the Favaloro Foundation was performed. Results: A total of 45 patients underwent pericardiectomy between June 1992 and June 2022, mean age was 52 years (standard deviation ± 13.9 years), and 73.3% were men. Idiopathic constrictive pericarditis was the most prevalent (46.6%). The variables significantly associated with prolonged hospitalization were preoperative advanced functional class (incidence of 38.4%, P&lt;0.04), persistent pleural effusion (incidence of 81.8%, P&lt;0.01), and although there was no statistical significance with the use of cardiopulmonary bypass, a trend in this association is evident (P&lt;0.07). We found that 100% of the patients with an onset of symptoms greater than six months had a prolonged hospital stay. In-hospital mortality was 6.6%, and 30-day mortality was 8.8%. The preserved functional class is 17 times more likely to improve their symptomatology after pericardiectomy (odds ratio 17, 95% confidence interval 2.66-71; P&lt;0.05). Conclusion: Advanced functional class at the time of pericardiectomy is the variable most strongly associated with mortality and prolonged hospitalization. Onset of the symptoms greater than six months is also a poor prognostic factor mainly associated with prolonged hospitalization; based on these data, we strongly support the recommendation of early intervention.
DOI: 10.6084/m9.figshare.22785336.v1
title: Surgical Treatment of Constrictive Pericarditis

description: ABSTRACT Introduction: The mainstay of the treatment of constrictive pericarditis is pericardiectomy. However, surgery is associated with high early morbidity and mortality and low long-term survival. The aim of this study is to describe our series of pericardiectomies performed over 30 years. Methods: A descriptive, observational, and retrospective analysis of all pericardiectomies performed at the Institute of Cardiology and Cardiovascular Surgery of the Favaloro Foundation was performed. Results: A total of 45 patients underwent pericardiectomy between June 1992 and June 2022, mean age was 52 years (standard deviation ± 13.9 years), and 73.3% were men. Idiopathic constrictive pericarditis was the most prevalent (46.6%). The variables significantly associated with prolonged hospitalization were preoperative advanced functional class (incidence of 38.4%, P&lt;0.04), persistent pleural effusion (incidence of 81.8%, P&lt;0.01), and although there was no statistical significance with the use of cardiopulmonary bypass, a trend in this association is evident (P&lt;0.07). We found that 100% of the patients with an onset of symptoms greater than six months had a prolonged hospital stay. In-hospital mortality was 6.6%, and 30-day mortality was 8.8%. The preserved functional class is 17 times more likely to improve their symptomatology after pericardiectomy (odds ratio 17, 95% confidence interval 2.66-71; P&lt;0.05). Conclusion: Advanced functional class at the time of pericardiectomy is the variable most strongly associated with mortality and prolonged hospitalization. Onset of the symptoms greater than six months is also a poor prognostic factor mainly associated with prolonged hospitalization; based on these data, we strongly support the recommendation of early intervention.
DOI: 10.6084/m9.figshare.22785337
title: Effect of perinatal and postnatal thiamine deficiency on auditory pathway of the Wistar-Albino rats

description: Abstract Objective: In this study, we created an animal model to demonstrate the effects of thiamine on the hearing pathways of new-borns during pregnancy and lactation by inducing a dietary thiamine deficiency in the mother. Methods: The study included 16 female Wistar albino rats. The animals were separated into four groups and provided the appropriate amounts of dietary thiamine according to their groups during pre-pregnancy, pregnancy, and lactation periods. Three pups from each mother were included in the study, and 12 pups were selected from each group. On the fortieth day after birth, the auditory pathways of 48 pups in the 4 groups were examined electro physiologically and ultra-structurally. Results: In Group N-N, morphology of hair cells stereocilia degeneration was not obtained in all turns of cochlea. In Group N-T, Inner Hair Cells (IHCs) and Outher Hair Cells (OHCs) stereocilia didn’t show degeneration in all turns of cochlea but had rupture inrows of HCs stereocilia. In group T-N IHCs stereocilia less degeneration was observed in all turns of cochlea. OHC stereocilia partial loss was observed only in basal turn of cochlea. In Group T-T IHCs stereocilia was observed less degeneration and rupture in all turns of cochlea. Conclusion: Thiamine is vital for the development of cochlear hair cells during both prenatal and postnatal periods. Even partial deficiency of thiamine causes significant degeneration to the auditory pathway. Level of evidence: The level of evidence of this article is 5. This article is an experimental animal and laboratory study.
DOI: 10.6084/m9.figshare.22785337.v1
title: Effect of perinatal and postnatal thiamine deficiency on auditory pathway of the Wistar-Albino rats

description: Abstract Objective: In this study, we created an animal model to demonstrate the effects of thiamine on the hearing pathways of new-borns during pregnancy and lactation by inducing a dietary thiamine deficiency in the mother. Methods: The study included 16 female Wistar albino rats. The animals were separated into four groups and provided the appropriate amounts of dietary thiamine according to their groups during pre-pregnancy, pregnancy, and lactation periods. Three pups from each mother were included in the study, and 12 pups were selected from each group. On the fortieth day after birth, the auditory pathways of 48 pups in the 4 groups were examined electro physiologically and ultra-structurally. Results: In Group N-N, morphology of hair cells stereocilia degeneration was not obtained in all turns of cochlea. In Group N-T, Inner Hair Cells (IHCs) and Outher Hair Cells (OHCs) stereocilia didn’t show degeneration in all turns of cochlea but had rupture inrows of HCs stereocilia. In group T-N IHCs stereocilia less degeneration was observed in all turns of cochlea. OHC stereocilia partial loss was observed only in basal turn of cochlea. In Group T-T IHCs stereocilia was observed less degeneration and rupture in all turns of cochlea. Conclusion: Thiamine is vital for the development of cochlear hair cells during both prenatal and postnatal periods. Even partial deficiency of thiamine causes significant degeneration to the auditory pathway. Level of evidence: The level of evidence of this article is 5. This article is an experimental animal and laboratory study.
DOI: 10.6084/m9.figshare.22785340
title: Evaluation of phytotoxic, cytotoxic, and genotoxic potential of hemodialysis effluent

description: ABSTRACT The number of patients undergoing hemodialysis treatment increases and, consequently, the volume of effluent generated. This effluent presents high concentration of salts, nitrogen, and organic matter; furthermore, it may contain drugs and microorganisms. At the municipal level, hemodialysis effluent is piped to sewage networks and discharged to surface water. Toxicological tests using seeds provide reliable answers, with simplicity and low cost of procedures and materials; however, it does not allow to identify the agent that causes toxicity, but the toxicity of the set of contaminants. In this sense, the objective of this work was to evaluate phytotoxicity, cytotoxicity, and genotoxicity of the hemodialysis effluent generated in the largest hospital of the southern region of Rio Grande do Sul. Composite samples collected at the beginning, middle and end of each session on five machines and different shifts were used. Pure and diluted effluent, water for the composition of the dialysate, pure and diluted dialysate and control were tested. The phytotoxicity tests were performed with seeds of Verde Comprido cucumber, and Regina de Verão and Rabo-de-Galo lettuce. For cytogenotoxicity analyses, Baia Periforme onion seeds were used. It was observed that the pure hemodialysis effluent and dialysate had a toxic effect on all analyzed seeds. Although the diluted effluent did not cause phytotoxicity in lettuce and cucumber, cytogenotoxicity tests showed a decrease in mitotic index and appearance of chromosomal aberrations in onion cells, indicating toxicity at a cellular and genetic level. These results allow to conclude that this effluent cannot be directly dumped into water resources, nor can it be reused in irrigation without prior treatment.
DOI: 10.6084/m9.figshare.22785340.v1
title: Evaluation of phytotoxic, cytotoxic, and genotoxic potential of hemodialysis effluent

description: ABSTRACT The number of patients undergoing hemodialysis treatment increases and, consequently, the volume of effluent generated. This effluent presents high concentration of salts, nitrogen, and organic matter; furthermore, it may contain drugs and microorganisms. At the municipal level, hemodialysis effluent is piped to sewage networks and discharged to surface water. Toxicological tests using seeds provide reliable answers, with simplicity and low cost of procedures and materials; however, it does not allow to identify the agent that causes toxicity, but the toxicity of the set of contaminants. In this sense, the objective of this work was to evaluate phytotoxicity, cytotoxicity, and genotoxicity of the hemodialysis effluent generated in the largest hospital of the southern region of Rio Grande do Sul. Composite samples collected at the beginning, middle and end of each session on five machines and different shifts were used. Pure and diluted effluent, water for the composition of the dialysate, pure and diluted dialysate and control were tested. The phytotoxicity tests were performed with seeds of Verde Comprido cucumber, and Regina de Verão and Rabo-de-Galo lettuce. For cytogenotoxicity analyses, Baia Periforme onion seeds were used. It was observed that the pure hemodialysis effluent and dialysate had a toxic effect on all analyzed seeds. Although the diluted effluent did not cause phytotoxicity in lettuce and cucumber, cytogenotoxicity tests showed a decrease in mitotic index and appearance of chromosomal aberrations in onion cells, indicating toxicity at a cellular and genetic level. These results allow to conclude that this effluent cannot be directly dumped into water resources, nor can it be reused in irrigation without prior treatment.
DOI: 10.6084/m9.figshare.22785339
title: Tumor risk markers in recurrent respiratory papillomatosis

description: Abstract Objectives: This study aims to investigate the pattern of immunoexpression of proteins p16, p53 and Ki-67 in RRP, as well as to evaluate its influence on the number of surgeries that patients have undergone to date and to analyze the benefit of immunohistochemistry in this disease. Methods: Clinical-demographic data and tumor samples were obtained from 33 patients with RRP. The expression of proteins p16, p53 and Ki-67 was analyzed by immunohistochemical method. Results: Most patients had already undergone more than one surgery. The p16 marker was negative in 24.2% of the cases, with little positivity in 27.3% of the cases, moderate in 36.4% and intense in 12.1%. The p53 marker was positive in all cases, with little immunoexpression in 39.4% of cases, moderate in 36.4% and intense in 24.2%. The Ki-67 marker showed nuclear positivity in all lesions, although in varying degrees, with a mean proliferative index ±SD (standard deviation) of 51.7±26. Conclusions: The papillomatous lesions had varying degrees of immunoexpression of proteins p16, p53 and Ki-67, but no specific immunohistochemical pattern was observed. It was found, with statistical difference, that the number of surgeries was higher in cases with greater intensity of p53 expression, without correlation with the other markers. The benefit of immunohistochemistry in recurrent respiratory papillomatosis may lie in the prognostic assessment. However, further studies are needed to evaluate the use of this technique for this purpose. Level of evidence:: 4.
DOI: 10.6084/m9.figshare.22785339.v1
title: Tumor risk markers in recurrent respiratory papillomatosis

description: Abstract Objectives: This study aims to investigate the pattern of immunoexpression of proteins p16, p53 and Ki-67 in RRP, as well as to evaluate its influence on the number of surgeries that patients have undergone to date and to analyze the benefit of immunohistochemistry in this disease. Methods: Clinical-demographic data and tumor samples were obtained from 33 patients with RRP. The expression of proteins p16, p53 and Ki-67 was analyzed by immunohistochemical method. Results: Most patients had already undergone more than one surgery. The p16 marker was negative in 24.2% of the cases, with little positivity in 27.3% of the cases, moderate in 36.4% and intense in 12.1%. The p53 marker was positive in all cases, with little immunoexpression in 39.4% of cases, moderate in 36.4% and intense in 24.2%. The Ki-67 marker showed nuclear positivity in all lesions, although in varying degrees, with a mean proliferative index ±SD (standard deviation) of 51.7±26. Conclusions: The papillomatous lesions had varying degrees of immunoexpression of proteins p16, p53 and Ki-67, but no specific immunohistochemical pattern was observed. It was found, with statistical difference, that the number of surgeries was higher in cases with greater intensity of p53 expression, without correlation with the other markers. The benefit of immunohistochemistry in recurrent respiratory papillomatosis may lie in the prognostic assessment. However, further studies are needed to evaluate the use of this technique for this purpose. Level of evidence:: 4.
DOI: 10.6084/m9.figshare.22785342
title: Translating management ideas: consultants as language artificers

description: Abstract Using translation theory and management ideas literature, we aim to understand how organizational consultants use linguistic elements to circulate management ideas. We carried out a qualitative study with 16 consultants, using content and rhetoric analysis in semi-structured interviews. Results indicate the use of translation throughout the consultants’ work, allowing them to obtain legitimacy in the field. We showed that to move between different segments and organizational sizes, consultants persuasively use rhetoric, combined with practical and theoretical knowledge, through a mechanism we call ‘translation into practice,’ which aims to adapt concepts to the realities consulted. Consultants also resort to specific vocabularies and language games, emphasizing the strategic importance of language use for this occupational group that aims to professionalize itself in contemporary society.
DOI: 10.6084/m9.figshare.22785342.v1
title: Translating management ideas: consultants as language artificers

description: Abstract Using translation theory and management ideas literature, we aim to understand how organizational consultants use linguistic elements to circulate management ideas. We carried out a qualitative study with 16 consultants, using content and rhetoric analysis in semi-structured interviews. Results indicate the use of translation throughout the consultants’ work, allowing them to obtain legitimacy in the field. We showed that to move between different segments and organizational sizes, consultants persuasively use rhetoric, combined with practical and theoretical knowledge, through a mechanism we call ‘translation into practice,’ which aims to adapt concepts to the realities consulted. Consultants also resort to specific vocabularies and language games, emphasizing the strategic importance of language use for this occupational group that aims to professionalize itself in contemporary society.
DOI: 10.6084/m9.figshare.22785343
title: Amorphous breast calcifications: is BI-RADS 4a appropriate?

description: Abstract Objective: To evaluate the positive predictive value (PPV) of amorphous calcifications and to analyze the imaging variables that could alter the risk of malignancy associated with this finding. Materials and Methods: This was a retrospective study of 138 stereotactically guided percutaneous vacuum-assisted biopsies of amorphous calcifications, performed between January 2012 and December 2017. All of the patients included were referred for radiological follow-up for a minimum of one year (if the histopathology showed a benign lesion) or for surgical treatment (if the histopathology showed malignancy or a lesion of uncertain malignant potential). Results: We found that the PPV of amorphous calcifications was 9.42%. However, most of the malignant amorphous calcifications were in cases of invasive carcinoma or high-grade ductal carcinoma in situ, indicating clinically relevant disease. The relative risk of malignancy associated with amorphous calcifications was 6.15 times higher in patients with a family or personal history of breast or ovarian cancer. Neither being postmenopausal nor having dense breasts was found to be predictive of malignancy in patients with amorphous calcifications. Conclusion: Amorphous calcifications in the breast had a PPV for malignancy of 9.42%, indicating the possibility of placing the finding in subcategory 4a, which requires histopathological analysis. Our finding that the risk of malignancy associated with this subtype of calcifications is up to 6.15 times higher in patients with a family or personal history of breast cancer warrants greater concern regarding the clinical, radiologic, and histopathologic correlations after biopsy.
DOI: 10.6084/m9.figshare.22785343.v1
title: Amorphous breast calcifications: is BI-RADS 4a appropriate?

description: Abstract Objective: To evaluate the positive predictive value (PPV) of amorphous calcifications and to analyze the imaging variables that could alter the risk of malignancy associated with this finding. Materials and Methods: This was a retrospective study of 138 stereotactically guided percutaneous vacuum-assisted biopsies of amorphous calcifications, performed between January 2012 and December 2017. All of the patients included were referred for radiological follow-up for a minimum of one year (if the histopathology showed a benign lesion) or for surgical treatment (if the histopathology showed malignancy or a lesion of uncertain malignant potential). Results: We found that the PPV of amorphous calcifications was 9.42%. However, most of the malignant amorphous calcifications were in cases of invasive carcinoma or high-grade ductal carcinoma in situ, indicating clinically relevant disease. The relative risk of malignancy associated with amorphous calcifications was 6.15 times higher in patients with a family or personal history of breast or ovarian cancer. Neither being postmenopausal nor having dense breasts was found to be predictive of malignancy in patients with amorphous calcifications. Conclusion: Amorphous calcifications in the breast had a PPV for malignancy of 9.42%, indicating the possibility of placing the finding in subcategory 4a, which requires histopathological analysis. Our finding that the risk of malignancy associated with this subtype of calcifications is up to 6.15 times higher in patients with a family or personal history of breast cancer warrants greater concern regarding the clinical, radiologic, and histopathologic correlations after biopsy.
DOI: 10.6084/m9.figshare.22785345
title: Health education can save the environment from medicine residues

description: Abstract The incorrect disposal of medicines and their environmental impact has been related to the health medicalization and the improper use of medication by society. In this sense, it is very important to know the profile of drug disposal for foster health policies. The aim was to identify the profile of disposal of medicines by the population, including the cost perspective. This is an inquiry descriptive study that began in September 2019. Medicine disposal health education program was carried out over six months in two University pharmacies. A questionnaire for sociodemographic and discarded medicines data collection was applied. Logistic regression analysis for variables association of correct disposal and the chi-square and t-student analysis for comparison between disposal programs were performed for a level of 5% and test power of 80%. Medicines weighed 23.3 kg and 28.5 kg, with the cost variation from US$ 13.5 to US$ 16.1 until the final treatment. The correct disposal was strongly associated with the disposal reason (p=0.013), source of information (p=0.006), prescription (p=0.03), form of use (p=0.01), acquisition source (p=0.001), cost with medication (p=0.0001), education (p=0.028) and age (p=0.05). The correct medicine disposal was associated with important features of the community related to education health.
DOI: 10.6084/m9.figshare.22785345.v1
title: Health education can save the environment from medicine residues

description: Abstract The incorrect disposal of medicines and their environmental impact has been related to the health medicalization and the improper use of medication by society. In this sense, it is very important to know the profile of drug disposal for foster health policies. The aim was to identify the profile of disposal of medicines by the population, including the cost perspective. This is an inquiry descriptive study that began in September 2019. Medicine disposal health education program was carried out over six months in two University pharmacies. A questionnaire for sociodemographic and discarded medicines data collection was applied. Logistic regression analysis for variables association of correct disposal and the chi-square and t-student analysis for comparison between disposal programs were performed for a level of 5% and test power of 80%. Medicines weighed 23.3 kg and 28.5 kg, with the cost variation from US$ 13.5 to US$ 16.1 until the final treatment. The correct disposal was strongly associated with the disposal reason (p=0.013), source of information (p=0.006), prescription (p=0.03), form of use (p=0.01), acquisition source (p=0.001), cost with medication (p=0.0001), education (p=0.028) and age (p=0.05). The correct medicine disposal was associated with important features of the community related to education health.