cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.25347550
title: Supplementary Material for: Peeling Back the Layers: Recurrent Talquetamab Skin Toxicity After Supportive Stem Cell Boost in Multiple Myeloma

description: Bispecific antibodies have meaningfully expanded the therapeutic armentarium in multiple myeloma. Talquetamab is a CD3+ T cell redirecting antibody targeting GPRC5D, which is expressed on multiple myeloma plasma cells as well as in keratinized tissues. Due to the expression pattern, toxicity of talquetamab involves skin toxicity. 
Here we report the case of a patient who was treated with talquetamab after relapse after CAR-T therapy. The patient developed a severe recurrence of talquetamab-mediated skin toxicity after the administration of a supportive hematopoietic stem cell boost to treat persistent late cytopenias after CAR-T therapy. This case underscores the complex dynamics between novel immunotherapies like talquetamab and stem cell-based interventions in the context of MM treatment, shedding light on the need for personalized approaches to maximize the benefits of these therapies while minimizing their associated adverse effects.
DOI: 10.6084/m9.figshare.25399609
title: Supplementary Material for: The IRE1α-endonuclease plays a dual role in regulating the XBP1/miRNA-34a axis and PD-1 expression within Natural Killer cells in Hodgkin Lymphoma

description: Introduction: Hodgkin Lymphoma (HL) is deficient in Major Histocompatibility Complex-class I, rendering it susceptible to anti-tumoral immunity by Natural Killer (NK)-cells. Despite the functional impairment of PD-1+ NK-cells in HL, the underlying mechanisms of NK-cell dysfunction remain unclear. Methods: This study involved 14 HL patients and SNK10/KHYG-1 cell lines to assess NK-cell activation against cancer cells. Activation was measured through transcript (PCR) and protein expression (flow cytometry). Regulatory mechanisms associated with IRE1α activation were validated through knock-down and luciferase reporter assays. Results: Our findings reveal a novel role for IRE1α-endonuclease in fine-tuning NK-cell effector functions by orchestrating the XBP1s/microRNA-34a-5p/PD-1 axis. When NK-cells encounter cancer cells, IRE1α-endonuclease activates the decay of microRNA-34a-5p, resulting in increased expression of XBP1s and PD-1. IRE1α-endonuclease activation enhances NK-cells function while promoting PD-1 expression. In turn, PD-1 is directly regulated by microRNA-34a-5p, which binds to the 3’UTR of PD-1 transcript to repress PD-1 protein on the NK-cell surface. Importantly, IRE1α-pathway activation is impaired in NK-cells from HL patients. Conclusion: The IRE1α-endonuclease emerges as a key player, simultaneously regulating the XBP1s/microRNA-34a-5p/PD-1 axis in NK-cells, a process disrupted in HL. Targeting the IRE1α-pathway holds promise as a therapeutic strategy to optimise NK-cell functions in Hodgkin Lymphoma treatments.
DOI: 10.6084/m9.figshare.27281550
title: Supplementary Material for: Development of an Artificial Intelligence System for Distinguishing Malignant from Benign Soft Tissue Tumors Using Contrast-Enhanced MR Images

description: Introduction: The integration of artificial intelligence (AI) into orthopedics has enhanced the diagnosis of various conditions; however, its use in diagnosing soft-tissue tumors remains limited owing to its complexity. This study aimed to develop and assess an AI-driven diagnostic support system for magnetic resonance imaging (MRI)-based soft-tissue tumor diagnosis, potentially improving accuracy and aiding radiologists and orthopedic surgeons.
Methods: Experienced orthopedic oncologists and radiologists annotated 720 images from 77 cases (41 benign and 36 malignant soft-tissue tumors). Eleven tumor subtypes were identified and classified into benign and malignant groups based on histological diagnosis. Utilizing the standard machine learning classifier pipeline, we examined and down-selected imaging protocols and their predominant radiomic features within the tumor's three-dimensional region to differentiate between benign and malignant tumors. Among the scan protocols, contrast-enhanced T1 weighted fat-suppressed images showed the most accurate classification based on radiomics features. We focused on the two-dimensional features from the largest tumor boundary surface and its neighboring slices, leveraging texture-based radiomic and deep convolutional neural network features from a pretrained VGG19 model.
Results: The test data comprised 44 contrast-enhanced images (22 benign and 22 malignant soft-tissue tumors) containing six malignant and five benign subtypes distinct from the training data. We compared expert and non-expert human performances against AI by assessing malignancy detection and the time required for classification. The AI model showed comparable accuracy (AUC 0.91) to that of radiologists (AUC 0.83) and orthopedic surgeons (AUC 0.73). Notably, the AI model processed data approximately 400 times faster than its human counterparts, showcasing its capacity to significantly boost diagnostic efficiency.
Conclusion: We developed an AI-driven diagnostic support system for MRI-based soft-tissue tumor diagnosis. While additional refinement is necessary for clinical applications, our system has exhibited promising potential in differentiating between benign and malignant soft-tissue tumors based on MRI.
DOI: 10.6084/m9.figshare.27443187
title: Supplementary Material for: Exploring Recovery Priorities in Inpatient Addiction Treatment: A Q-Methodological Study

description: Introduction: Recovery from Substance Use Disorder (SUD) is increasingly recognized as a personal journey, necessitating an approach that considers individual goals and priorities. Research on recovery priorities in inpatient settings is limited. Our study employs Q-methodology to explore recovery priorities among clients with multimorbid SUD, aiming to guide targeted, recovery-oriented care.
Methods: This cross-sectional study employed Q-methodology to explore recovery priorities among 129 individuals entering inpatient addiction treatment. A collaboratively developed Q-set of 42 statements covered clinical, functional, and personal recovery goals. Participants ranked statements by importance, and rotated factor analysis was used to identify clusters of recovery priorities. Qualitative interview data were then analyzed for further interpretation.
Results: We found 12 consensus statements and two distinct factors. Factor 1 (n=60) emphasized personal growth and coping, while Factor 2 (n=51) highlighted practical aspects such as securing income and housing. Qualitative data supported these findings.
Conclusions: Despite the individual nature of recovery and the diversity within the addiction treatment population, our study identified shared goals and two distinct factors. This insight can inform tailored interventions, with Factor 1 individuals potentially favoring psychological approaches and Factor 2 individuals focusing on practical goals.
DOI: 10.6084/m9.figshare.27929796
title: Supplementary Material for: Screening for cognitive impairment in the emergency department: agreement between older adult patient- and informant-completed Ascertain Dementia 8 tool

description: Introduction
Emergency department (ED) screening for cognitive impairment (CI) is crucial for early intervention, yet guidance on dementia screening protocols remains limited. Our objective was to assess the concordance between the Ascertain Dementia 8 (AD8), a brief screening tool for CI, administered to ED patients and their informants.

Methods
We conducted a prospective observational study of dyads, including patients ≥65 years without a diagnosis of dementia seeking care in the ED and their informants (e.g. family, friend with close contact). Trained research assistants used the 4AT to exclude patients with concern for delirium. The AD8 was then administered to blinded patients (pAD8) and informants (iAD8), with scores ranging from 0-8 and scores of ≥2 indicating CI. We used the Intraclass Correlation Coefficient (ICC) to calculate the level of agreement between AD8 scores.

Results
Our analytic sample included 538 dyads, of which 63.3% of patients were female with a mean age of 73.5 years. A total of 131 (24.3%) patients without a diagnosis of dementia self-identified as having CI using the pAD8, in comparison to 110 (20.4%) informants using the iAD8. The ICC of 0.519 (95% CI 0.454-0.578) indicated moderate agreement between pAD8 and iAD8 scores.

Conclusions
When seeking emergency care, one in four older adults without a diagnosis of dementia and approximately 20% of informants indicated that patients were cognitively impaired. Our finding of moderate agreement between the pAD8 and iAD8 has important implications for clinicians providing care to patients with suspected CI and investigators conducting dementia-related studies.
DOI: 10.6084/m9.figshare.27929946
title: Supplementary Material for: Prevalence of patent processus vaginalis diagnosed using laparoscopy during peritoneal dialysis catheter insertion and subsequent genital edema: A prospective observational study

description: Introduction: Inguinal hernia and genital edema are relatively common complications of peritoneal dialysis (PD). Although patent processus vaginalis (PV) is considered an important factor associated with these complications, the prevalence of patent PV at PD initiation and whether it leads to these complications have not been fully identified. 
Methods: A total of 71 patients were included in this study, 41 of whom underwent laparoscopy-assisted catheter placement. The remaining 30 patients did not undergo laparoscopy mainly because of a lack of patient consent. During laparoscopy, if a dimple or small canal toward the deep inguinal ring was observed, the groin was diagnosed as a patent PV.
Results: Laparoscopy revealed that nine of 41 patients (22%) had patent PV (male, 29.6%; female, 7.1%). Genital edema occurred in two of the nine patients with patent PV at 8.9 and 11.4 months after PD initiation, respectively. However, none of 32 patients without patent PV developed this complication. Two of 30 patients without laparoscopic inspection presented with genital edema at 6.7 and 12.4 months after PD initiation, respectively. Among the 71 patients, body mass index was significantly higher in patients with this complication than in those without (28.8 vs. 22.8, P 0.013).
Conclusion: Although the number of patients with patent PV who manifested genital edema was small, our results suggest that patent PV at PD initiation may be an important contributor for genital edema in patients undergoing PD. Further studies are needed to determine whether the repair of patent PV could prevent subsequent genital edema.
DOI: 10.6084/m9.figshare.27605637
title: Supplementary Material for: The temporal relation of physical function with cognition and the influence of brain health in the oldest-old

description: Introduction
Physical function and cognition seem to be interrelated, especially in the oldest-old. However, the temporal order in which they are related and the role of brain health remain uncertain.
Methods
We included 338 participants (mean age 93.1 years) from two longitudinal cohorts: The UCI 90+ Study and EMIF-AD 90+ Study. We tested the association between physical function (Short Physical Performance Battery, gait speed and handgrip strength) at baseline with cognitive decline (MMSE, memory tests, Animal fluency, Trail Making Test (TMT) A and Digit Span Backward), and the association between cognition at baseline with physical decline (mean follow-up 3.3 years). We also tested whether measures for brain health (hippocampal, white matter lesion and gray matter volume) were related to physical function and cognition, and whether brain health was a common driver of the association between physical function and cognition by adding it as confounder (if applicable).
Results
Better performance on all physical tests at baseline was associated with less decline on MMSE, memory and TMT A. Conversely, fewer associations were significant but better scores on memory, TMT A and Digit Span Backward were associated with less physical decline. When adding measures for brain health as confounder, all associations stayed significant except for memory with gait speed decline.
Discussion
In the oldest-old, physical function and cognition are strongly related, independently of brain health. Also, the association between physical function and cognitive decline is more pronounced than the other way around, suggesting a potential for slowing cognitive decline by optimizing physical function.
DOI: 10.6084/m9.figshare.27088168
title: Supplementary Material for: COVID-19 Related Spinal Subdural Hematoma Presented with Acute Compressive Myelopathy with review of the literature

description: Neurological complication due to Coronavirus Disease 2019 is accumulating and compressive myelopathy due to spinal subdural hematoma is rarely reported in association with COVID-19. A 55-year-old male was presented with sudden onset of areflexic paraparesis, urinary retention, loss of all sensations below twelve spinal thoracic segment, and severe back pain. This condition necessitated an immediate order of spinal cord MRI followed by an urgent surgery, which was crucial to save the spinal cord. COVID-19 was confirmed by positive RT-PCR and spinal MRI showed SSDH.
DOI: 10.6084/m9.figshare.27928785
title: Supplementary Material for: Hub metabolites promote the bioflocculants’ production in a biomass-degrading bacterium Pseudomonas boreopolis GO2

description: Introduction: The low yield of bioflocculants has been a bottleneck problem that limits their industrial applications. Understanding the metabolic mechanism of bacteria that produce bioflocculants, could provide valuable insights and strategies to directly regulate their yield in future. Methods: To investigate the change of metabolites in the process of bioflocculant production by a biomass-degrading bacterium, Pseudomonas boreopolis GO2, an untargeted metabolome analysis was performed. Results: The results showed that metabolites significantly differed during the fermentation process when corn stover was used as the sole carbon source. The differential metabolites were divided into four co-expression modules based on the weighted gene co-expression network analysis. Among them, a module (yellow module) was closely related to the flocculating efficiency, and the metabolites in this module were mainly involved in carbohydrate, lipid and amino acid metabolism. The top 30 metabolites with the highest degree in the yellow module were identified as hub metabolites for bioflocculants’ production. Finally, 10 hub metabolites were selected to perform the additional experiments, and the addition of L-rhamnose, tyramine, tryptophan, and glutaric acid alone all could significantly improve the flocculating efficiency of GO2 strain. Conclusion: These results indicated that the hub metabolites were key for bioflocculant production in GO2 strain, and could help guide the improvement of high-efficiency and low-cost bioflocculant production.
DOI: 10.1285/i20705948v16n1p165
title: Intention to Purchase Family Takaful Policy: Evaluation of the Mediating E

description: This paper aims to investigate the factors affecting individuals' intention to purchase family takaful policies in Pakistan. The extended version of the Decomposed Theory of Planned Behaviour (DTPB) with perceived trust was adopted as a theoretical foundation of the current study model. A total of 449 questionnaires were collected using a judgemental sampling technique and analyzed using SmartPLS. Of all the hypotheses, one was rejected. Attitude and subjective norms were found to have a positive relationship with intention. Perceived religiosity and knowledge were found to have a positive relationship with attitude. In addition to that, media referent and word of mouth were found to have a positive relationship with subjective norm while financial self-efficacy and resource facilitating conditions were found to have a positive relationship with perceived behavioral control. The mediating analysis suggested that trust mediates the relationship between religiosity and attitude. However, perceived behavioral control was found to have an insignificant relationship with intention. The results of this study highlight the applicability of DTPB into life insurance research and suggest marketing strategies for sustainable and survival of the takaful companies in Pakistan. The value of this paper lies in its presentation of a model for factors that affect an individual's intention to purchase family takaful policy.
DOI: 10.15121/1572361
title: GeoVision: Harnessing the Heat Beneath Our Feet - Analysis Inputs and Results

description: This submission includes input and results data from analysis done as part of the Geothermal Technology Office's Geothermal Vision Study (GeoVision). The submission includes data for both analysis of the electricity sector and the heating and cooling sector. For the electricity sector, the submission includes geothermal resource potential and development cost inputs for the ReEDS model and ReEDS model results of projected installed capacity and generation of geothermal and other technologies under the GeoVision scenarios. It also includes results from environmental and social impacts analysis. For the cooling sector, the submission includes geothermal resource potential and development cost inputs for the dGeo model and dGeo model results of economic, market, and deployment potential.
DOI: 10.17189/1519440
title: MSL MARS ALPHA PARTICLE X-RAY SPECTROMETER 4/5 RDR V1.0
DOI: 10.17189/1519534
title: MSL MARS ALPHA PARTICLE X-RAY SPECTROMETER 2 EDR V1.0
DOI: 10.17632/275fcvkhkg.1
title: Smuggling_JIE

description: Replication Folder for smuggling paper
DOI: 10.17632/65f4f4j3mg.2
title: Data for " Thermoelastic Properties of Seifertite at High Pressures and Temperatures: Implications for Negative Velocity Discontinuities in the D'' layer"

description: The thermoelastic properties of seifertite under high-temperature and high-pressure conditions
DOI: 10.24403/jp.1296775
title: Professionalisierung erleben, gestalten, begleiten und erforschen: Einleitung zur ersten Ausgabe von KONTEXTE / Julia Feike, Věra Janíková, Tatsuya Ohta, Kristina Peuschel, Constanze Saunders & Michael Schart
DOI: 10.5281/zenodo.11552040
title: Data for "An insect pheromone primes tolerance of herbivory in goldenrod plants"

description: Data for "An insect pheromone primes tolerance of herbivory in goldenrod plants"
Data include all raw data necessary for the analyses of the manuscript.  These include data on the growth, flower production, rhizome production, and gall induction of goldenrod plants (Solidago altissima) after exposure to a priming cue gradient and a specialist herbivore that is the source of the priming cue.  It also contains data on female herbivore oviposition preference.
 
Description of the data and file structure
The data are divided into four sheets.  The first contains data necessary for analyses presented in the main text.  The second contains data for analyses presented in the supplement.  The third presents data from a separate experiment presented in the supplement, and the fourth contains R code for the analyses performed.
 
Sharing/Access information
These data are currently only available on Zenodo.
DOI: 10.5281/zenodo.7428803
title: The potential for natural forest regeneration in tropical regions

description: Extensive forest restoration is a key strategy to meet nature-based sustainable development goals and provide multiple social and environmental benefits. Yet achieving forest restoration at scale requires cost-effective methods. Tree planting in degraded landscapes is a popular but costly forest restoration method, which often results in less biodiverse forests when compared to natural regeneration techniques under similar conditions. Here, we assess the current spatial distribution of pantropical natural forest (from 2000-2016) and use this information to present the first model of the potential for natural regeneration across tropical forested countries and biomes at 30-meter spatial resolution. We estimate that 215 million hectares - an area greater than the entire country of Mexico - have potential for natural forest regeneration, representing an above-ground carbon sequestration potential of 23.4 Gt CO2 (range 21.1-25.7 Gt) over 30 years. Five countries (Brazil, Indonesia, China, Mexico, and Colombia) account for 52% of this estimated potential, showcasing the need for targeting restoration initiatives that leverage natural regeneration potential. Our results facilitate broader equitable decision-making processes that capitalise on the widespread opportunity for natural regeneration to help achieve national and global environmental agendas. 

File descriptions:

pnv_pct_30m - files named with this prefix are the 30m continuous probability predictions of the potential for natural regeneration, stored as integers representing percentages to minimise file sizes 

tile_index_number_map.jpg – corresponding locations of the ‘pnv_pct_30m’ tiles 

prop pnv v1 1km.tif - for display purposes only (not used in the Williams et al. analysis) the approximately 1km resolution overview raster representing the proportion of the area of each pixel that has the potential for natural regeneration  

pnv_bin_30m.zip - this .zip folder contains the 30m resolution binary predictions (where a value of >0.5 is allocated a value of 1, acknowledging users may prefer to use a different threshold for their context) of areas suitable for natural regeneration 

The 30m resolution datasets have been tiled into 10 degree latitude/longitude tiles
DOI: 10.6073/pasta/920fe947b69eea415bdca0af3b3e33c9
title: Pollinator visitation, flower count, and seed set in Black Sand plots, 2020.

description: Anthropogenic climate change is altering interactions among numerous
 species, including plants and pollinators. Plant-pollinator
 interactions, crucial for the persistence of most plant and many
 insect species, are threatened by climate change-driven phenological
 shifts. Phenological mismatches between plants and their pollinators
 may affect pollination services, and simulations indicated that
 these mismatches may reduce floral resources available to up to 50%
 of insect pollinator species. Although alpine plants rely heavily on
 vegetative reproduction, seedling recruitment and seed dispersal are
 likely to be important drivers of alpine community structure.
 Similarly, advanced flowering may expose plants to increased risk of
 frost damage and shifted soil moisture regimes; phenologically
 advanced plants will experience these environmental factors
 differently, which may alter their floral resource production. These
 effects may be dependent upon topography. Some species of alpine
 plants on the Niwot Ridge have displayed advanced phenology under
 treatments of advanced snowmelt (Forrester, 2021). However, little
 is understood about how these differences in distribution and
 phenology affect pollinator community composition and plant
 fecundity. Here we strive to examine how experimentally-induced
 changes in the timing of flowering and number of flowers produced by
 plants impact plant-pollinator interactions and seed set. We also
 ask how topography and the number of flowers interact with early
 snowmelt to affect pollination rates and the diversity of
 pollinating insects. Finally, we ask how seed set of Geum rossii is
 affected by pollinator visitation at different times of the season,
 under experimentally advanced snowmelt versus unmanipulated
 snowmelt, and with visitation by different insect taxa. In summer
 2020, we found that plots with advanced phenology experienced peaks
 in pollinator visitation rates and pollinator diversity earlier than
 plots with unmanipulated snowmelt. We expect this to be because of
 the advanced floral phenology of certain key species in these plots.
 
 
 References:
 
 
 Forrester, C.C. (2021). Advancing, Using, and Teaching Climate
 Change Ecology Research. [Doctoral dissertation, University of
 Colorado, Boulder]. ProQuest Dissertations and Theses.