cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.12017730
title: Hippocampal Atrophy in Systemic Lupus Erythematosus Patients without Major Neuropsychiatric Manifestations

description: This study was conducted to explore hippocampal structural changes and their possible associations with clinical characteristics, emotional status and treatment regimens in patients with systemic lupus erythematosus (SLE) without major neuropsychiatric manifestations (non-NPSLE). Eighty-five non-NPSLE patients with normal conventional magnetic resonance imaging (MRI) and seventy-seven matched healthy control (HC) subjects were recruited. All participants underwent the standard high-resolution volumetric MRI. Bilateral hippocampal volume (HIPV) and hippocampal density (HIPD) were calculated respectively for each participant. We found that the bilateral HIPV and HIPD of the SLE patient group were significantly less than those of HC group. The bilateral HIPV of female patients were significantly less than those of male patients. SLE disease activity index (SLEDAI) was negatively correlated with the bilateral HIPV and the right HIPD. Urine protein quantity was negatively correlated with the bilateral HIPV and HIPD. Hydroxychloroquine (HCQ) showed a protective effect on right HIPV. In conclusion, we found that the early hippocampal atrophy could occur before obvious neuropsychiatric manifestations and might be associated with SLE disease activity and organ damages. Early detection and intervention of hippocampal damage might prevent the progression to NPSLE. More studies are needed to fully understand the underlying mechanisms of hippocampal atrophy in SLE.
DOI: 10.6084/m9.figshare.12017730.v1
title: Hippocampal Atrophy in Systemic Lupus Erythematosus Patients without Major Neuropsychiatric Manifestations

description: This study was conducted to explore hippocampal structural changes and their possible associations with clinical characteristics, emotional status and treatment regimens in patients with systemic lupus erythematosus (SLE) without major neuropsychiatric manifestations (non-NPSLE). Eighty-five non-NPSLE patients with normal conventional magnetic resonance imaging (MRI) and seventy-seven matched healthy control (HC) subjects were recruited. All participants underwent the standard high-resolution volumetric MRI. Bilateral hippocampal volume (HIPV) and hippocampal density (HIPD) were calculated respectively for each participant. We found that the bilateral HIPV and HIPD of the SLE patient group were significantly less than those of HC group. The bilateral HIPV of female patients were significantly less than those of male patients. SLE disease activity index (SLEDAI) was negatively correlated with the bilateral HIPV and the right HIPD. Urine protein quantity was negatively correlated with the bilateral HIPV and HIPD. Hydroxychloroquine (HCQ) showed a protective effect on right HIPV. In conclusion, we found that the early hippocampal atrophy could occur before obvious neuropsychiatric manifestations and might be associated with SLE disease activity and organ damages. Early detection and intervention of hippocampal damage might prevent the progression to NPSLE. More studies are needed to fully understand the underlying mechanisms of hippocampal atrophy in SLE.
DOI: 10.6084/m9.figshare.12017724
title: Supplementary Material for: Interactive Motion-Assisted Exposure Therapy for Veterans with Treatment-Resistant Posttraumatic Stress Disorder: A Randomized Controlled Trial

description: <b><i>Background:</i></b> Veterans with posttraumatic stress disorder (PTSD) tend to benefit less from evidence-based treatments than other PTSD populations. A novel virtual reality and motion-assisted exposure therapy, called 3MDR, provides treatment in an immersive, personalized and activating context. <b><i>Objective:</i></b> To study the efficacy of 3MDR for veterans with treatment-resistant PTSD. <b><i>Method:</i></b> In a randomized controlled trial (<i>n</i> = 43) 3MDR was compared to a non-specific treatment component control group. Primary outcome was clinician-rated PTSD symptoms at baseline, after 3MDR, and at the 12-week and 16-week follow-up (primary end point). Intention-to-treat analyses of covariance and mixed models were applied to study differences between groups at the end point and over the course of intervention, controlling for baseline scores. <b><i>Results:</i></b> The decrease in PTSD symptom severity from baseline to end point was significantly greater for 3MDR as compared to the control group, with a large effect size (<i>F</i>[1, 37] = 6.43, <i>p</i> = 0.016, <i>d</i> = 0.83). No significant between-group difference was detected in the course of PTSD symptoms during treatment when including all time points. The dropout rate was low (7%), and 45% of the patients in the 3MDR group improved clinically. The number needed to treat was 2.86. <b><i>Conclusions:</i></b> In this trial, 3MDR significantly decreased PTSD symptoms in veterans with, on average, a history of 4 unsuccessful treatments. The low dropout rate may be indicative of high engagement. However, a lack of significant differences on secondary outcomes limits conclusions that can be drawn on its efficacy and underlines the need for larger phase III trials. These data show emerging evidence for 3MDR and its potential to progress PTSD treatment for veterans (Dutch Trial Register Identifier: NL5126).
DOI: 10.6084/m9.figshare.12017730.v3
title: Hippocampal Atrophy in Systemic Lupus Erythematosus Patients without Major Neuropsychiatric Manifestations

description: This study was conducted to explore hippocampal structural changes and their possible associations with clinical characteristics, emotional status and treatment regimens in patients with systemic lupus erythematosus (SLE) without major neuropsychiatric manifestations (non-NPSLE). Eighty-five non-NPSLE patients with normal conventional magnetic resonance imaging (MRI) and seventy-seven matched healthy control (HC) subjects were recruited. All participants underwent the standard high-resolution volumetric MRI. Bilateral hippocampal volume (HIPV) and hippocampal density (HIPD) were calculated respectively for each participant. We found that the bilateral HIPV and HIPD of the SLE patient group were significantly less than those of HC group. The bilateral HIPV of female patients were significantly less than those of male patients. SLE disease activity index (SLEDAI) was negatively correlated with the bilateral HIPV and the right HIPD. Urine protein quantity was negatively correlated with the bilateral HIPV and HIPD. Hydroxychloroquine (HCQ) showed a protective effect on right HIPV. In conclusion, we found that the early hippocampal atrophy could occur before obvious neuropsychiatric manifestations and might be associated with SLE disease activity and organ damages. Early detection and intervention of hippocampal damage might prevent the progression to NPSLE. More studies are needed to fully understand the underlying mechanisms of hippocampal atrophy in SLE.
DOI: 10.6084/m9.figshare.12017730.v2
title: Hippocampal Atrophy in Systemic Lupus Erythematosus Patients without Major Neuropsychiatric Manifestations

description: This study was conducted to explore hippocampal structural changes and their possible associations with clinical characteristics, emotional status and treatment regimens in patients with systemic lupus erythematosus (SLE) without major neuropsychiatric manifestations (non-NPSLE). Eighty-five non-NPSLE patients with normal conventional magnetic resonance imaging (MRI) and seventy-seven matched healthy control (HC) subjects were recruited. All participants underwent the standard high-resolution volumetric MRI. Bilateral hippocampal volume (HIPV) and hippocampal density (HIPD) were calculated respectively for each participant. We found that the bilateral HIPV and HIPD of the SLE patient group were significantly less than those of HC group. The bilateral HIPV of female patients were significantly less than those of male patients. SLE disease activity index (SLEDAI) was negatively correlated with the bilateral HIPV and the right HIPD. Urine protein quantity was negatively correlated with the bilateral HIPV and HIPD. Hydroxychloroquine (HCQ) showed a protective effect on right HIPV. In conclusion, we found that the early hippocampal atrophy could occur before obvious neuropsychiatric manifestations and might be associated with SLE disease activity and organ damages. Early detection and intervention of hippocampal damage might prevent the progression to NPSLE. More studies are needed to fully understand the underlying mechanisms of hippocampal atrophy in SLE.
DOI: 10.6084/m9.figshare.12017652
title: Table S1.xlsx

description: Summary of the shearing experiments on simulated hornblende gouge
DOI: 10.6084/m9.figshare.12017652.v1
title: Table S1.xlsx

description: Summary of the shearing experiments on simulated hornblende gouge
DOI: 10.6084/m9.figshare.12017640
title: supplementary paper.xlsx

description: Age data for the Cape River Metamorphics, Charters Towers Metamorphics, Puddler Creek Formation, Fenian Granite, Cornelia Orthogneiss and Fat Hen Complex
DOI: 10.6084/m9.figshare.12017640.v1
title: supplementary paper.xlsx

description: Age data for the Cape River Metamorphics, Charters Towers Metamorphics, Puddler Creek Formation, Fenian Granite, Cornelia Orthogneiss and Fat Hen Complex
DOI: 10.6084/m9.figshare.12017634
title: Supplementary Table 1.docx

description: <b>Supplementary Table 1</b> Primer sequences
DOI: 10.6084/m9.figshare.12017634.v1
title: Supplementary Table 1.docx

description: <b>Supplementary Table 1</b> Primer sequences
DOI: 10.6084/m9.figshare.12017610
title: Data for "Distribution characteristics and release mechanisms of Pb in surface sediments in different aquatic environments"

description: Data for "Distribution characteristics and release mechanisms of Pb in surface sediments in different aquatic environments"
DOI: 10.6084/m9.figshare.12017610.v1
title: Data for "Distribution characteristics and release mechanisms of Pb in surface sediments in different aquatic environments"

description: Data for "Distribution characteristics and release mechanisms of Pb in surface sediments in different aquatic environments"
DOI: 10.6084/m9.figshare.12017562
title: Extended data SPIRIT Checklist

description: SPIRIT Checklist for COPCOV
DOI: 10.6084/m9.figshare.12017562.v1
title: Extended data SPIRIT Checklist

description: SPIRIT Checklist for COPCOV
DOI: 10.6084/m9.figshare.12017532
title: Table 1.xlsx

description: List of Experiments and Constitutive Parameters
DOI: 10.6084/m9.figshare.12017532.v1
title: Table 1.xlsx

description: List of Experiments and Constitutive Parameters
DOI: 10.6084/m9.figshare.12017382
title: Additional file 2 of Clinical-grade cryopreserved doxorubicin-loaded platelets: role of cancer cells and platelet extracellular vesicles activation loop

description: Additional file 2: Fig. S1. Time-lapse video using deconvolution microscopy demonstrates the capacity of DOX-loaded PLT to transfer DOX to MCF-7 breast cancer-derived cells.
DOI: 10.6084/m9.figshare.12017373
title: Additional file 3 of Identifying potential causal effects of age at menarche: a Mendelian randomization phenome-wide association study

description: Additional file 3:Table S1. Strength of the genetic instrument in predicting age at menarche in UK Biobank. Table S2. Findings from the main analysis of the genetic risk score for age at menarche. Table S3. Finding from the main analysis of the genetic risk score for age at menarche after additional adjustment for chip used for the genotyping. Table S4. Finding from the main analysis of the genetic risk score for age at menarche after Steiger filtering. Table S5. Findings from the sensitivity analysis of the genetic risk score for age at menarche excluding SNPs associated with childhood body-mass index. Table S6. Findings from the sensitivity analysis of the genetic risk score for age at menarche excluding SNPs associated with childhood and/or adult body-mass index. Table S7. MR-Egger intercept. Table S8. Results from MR-PRESSO global test for pleoitropy and distortion tests. Table S9. Strength of the genetic instrument in predicting age at menarche in ALSPAC. Table S10. Strength of the genetic instrument in predicting body-mass index and height in UK Biobank. Table S11. Findings from the multivariable mendelian randomization analysis further adjusting for body-mass index and height. Table S12. Post hoc power calculation analyses for the replication analyses.
DOI: 10.6084/m9.figshare.12017373.v1
title: Additional file 3 of Identifying potential causal effects of age at menarche: a Mendelian randomization phenome-wide association study

description: Additional file 3:Table S1. Strength of the genetic instrument in predicting age at menarche in UK Biobank. Table S2. Findings from the main analysis of the genetic risk score for age at menarche. Table S3. Finding from the main analysis of the genetic risk score for age at menarche after additional adjustment for chip used for the genotyping. Table S4. Finding from the main analysis of the genetic risk score for age at menarche after Steiger filtering. Table S5. Findings from the sensitivity analysis of the genetic risk score for age at menarche excluding SNPs associated with childhood body-mass index. Table S6. Findings from the sensitivity analysis of the genetic risk score for age at menarche excluding SNPs associated with childhood and/or adult body-mass index. Table S7. MR-Egger intercept. Table S8. Results from MR-PRESSO global test for pleoitropy and distortion tests. Table S9. Strength of the genetic instrument in predicting age at menarche in ALSPAC. Table S10. Strength of the genetic instrument in predicting body-mass index and height in UK Biobank. Table S11. Findings from the multivariable mendelian randomization analysis further adjusting for body-mass index and height. Table S12. Post hoc power calculation analyses for the replication analyses.
DOI: 10.6084/m9.figshare.12017178
title: 4-20-19 final dataset.xlsx

description: Dataset compiling at our institution 1) All ED visits for renal colic, 2) all ureteroscopies for stones meeting study criteria, 3) excluded subjects from set 2, 4) Average monthly temperature data from NOAA, 5) Original raw ureteroscopy data set. See Attached legend for explanation of numerical values
DOI: 10.6084/m9.figshare.12017178.v1
title: 4-20-19 final dataset.xlsx

description: Dataset compiling at our institution 1) All ED visits for renal colic, 2) all ureteroscopies for stones meeting study criteria, 3) excluded subjects from set 2, 4) Average monthly temperature data from NOAA, 5) Original raw ureteroscopy data set. See Attached legend for explanation of numerical values
DOI: 10.6084/m9.figshare.12017178.v2
title: 4-20-19 final dataset.xlsx

description: Dataset compiling at our institution 1) All ED visits for renal colic, 2) all ureteroscopies for stones meeting study criteria, 3) excluded subjects from set 2, 4) Average monthly temperature data from NOAA, 5) Original raw ureteroscopy data set. See Attached legend for explanation of numerical values
DOI: 10.6084/m9.figshare.12017139
title: Caribou in the cross-fire? Considering terrestrial lichen forage in the face of mountain pine beetle (Dendroctonus ponderosae) expansion

description: This dataset was prepared and made public as a requirement to publish the scientific article "Caribou in the cross-fire? Considering terrestrial lichen forage in the face of mountain pine beetle (<i>Dendroctonus ponderosae</i>) expansion" in the journal PLOS ONE. <br><br>All data used in this manuscript are housed within this repository. <br>
DOI: 10.6084/m9.figshare.12017133
title: RStudioTest.csv

description: i just want to get my bonus points
DOI: 10.6084/m9.figshare.12017139.v1
title: Caribou in the cross-fire? Considering terrestrial lichen forage in the face of mountain pine beetle (Dendroctonus ponderosae) expansion

description: This dataset was prepared and made public as a requirement to publish the scientific article "Caribou in the cross-fire? Considering terrestrial lichen forage in the face of mountain pine beetle (<i>Dendroctonus ponderosae</i>) expansion" in the journal PLOS ONE. <br><br>All data used in this manuscript are housed within this repository. <br>
DOI: 10.6084/m9.figshare.12017049
title: Supplementary Table 1

description: <b>Supplementary Table 1. Detailed clinical information of subjects.</b><b><br></b><b>Supplementary Table 2. Cluster of genes in hierarchical clustering analysis.</b><b>Supplementary Table 3. Genes with adjusted p-value less than 0.05 compared with healthy controls.</b><b>Supplementary Table 4. Differentially upregulated genes in comparison between diffuse cutaneous systemic sclerosis and healthy controls.</b><b>Supplementary Table 5. Differentially downregulated genes in comparison between diffuse cutaneous systemic sclerosis and healthy controls.</b>ACA, anti-centromere antibody; ATA, anti-topoisomerase antibody; RNAP, anti-RNA polymerase 3 antibody; RNP, anti-U1RNP antibody.
DOI: 10.6084/m9.figshare.12017028
title: Internationalization of Intrastate Armed Conflicts Dataset v.2.0-2020 (RFBR 18-314-00006\18)

description: This dataset is part of the research project on internationalization of intrastate armed conflicts funded by the Russian Foundation for Basic Research (RFBR). It proceeds from an alternative expanded conceptualization of the phenomenon of internationalized internal conflict which argues that accounting for involvement of external state-based actors into intrastate conflict is insufficient for understanding the complex interplay between various international, transnational and cross-border processes that form multiple reinforcing and counterbalancing links and feedback loops. To this end, we offer re-operationalization of the internationalization phenomenon based on an integrated three-dimensional framework which differentiates between three dimensions of internationalization (interpreted in a broader sense). The horizontal dimension (horizontal escalation) represents varied processes through which the spatial spread of organized violence (often originated on the sub-state level) affects the territory of other (usually neighboring) countries leading to consequences (usually destabilizing) for both the source state and the recipient state. The vertical dimension (vertical escalation) covers the processes by which either the structure of a conflict gets expanded to involve outside (foreign) actors, normally as secondary (supporting) parties, or (often as a result of the former) the nominal level of conflict gets upgraded from intrastate to interstate. Vertical escalation is enabled either through an attack by a source state on the territory or subjects of one or more of its neighbors (outward-directed vertical escalation), or alternatively through intervention by a state-based external actor into the original internal conflict (inward-directed vertical escalation). Finally, the systemic dimension (systemic escalation) denotes the expansion of international systemic limits of original conflict by increased political stake, interest and/or attention of various international actors vis-à-vis the conflict in question, through its “proxy-fication” or connectedness with other conflicts in the neighborhood. The proposed dimensions are conceptual constructs aimed at facilitating the analysis of conflict dynamics and are not intended to be interpreted literally.<br>This current version of the dataset (2.0) covers the universe of armed conflicts in the regions of Europe (excl. FSU), Former Soviet Union (FSU), and Asia for the period from 1975 to 2018, and the Middle East and North Africa region for the period from 1989 to 2018.<br>
DOI: 10.25375/uct.12017010
title: Children, Technology and Play – Qualitative Data

description: The aims of this collaborative research study between University of Cape Town and University of Sheffield study were to explore the contemporary play environments of children in order to identify the ways in which children’s play is shaped by technology, to examine the relationship between digital play, learning and creativity, and to explore the role of adults in mediating digital play. One of the five objectives was to understand the dynamics operating across the digital ecology of children’s play (in homes, communities and schools) in terms of synergies, dissonance and transfer, and to identify the implications for learning.<br>The study adopted a mixed-methods approach. Parents of 3-11 year-olds were invited to complete a survey, and 30 parents then took part in telephone interviews in order to follow-up themes from the survey in greater detail. Case studies with families were undertaken. In the case studies, parents and children were interviewed and videoed. Parents also filmed their children using technologies, and they and their children were asked questions about the videos. Parents were invited to share images and videos with researchers using WhatsApp. In addition, children in the families were given diaries to record their use of social media and television, and used Go-Pro cameras to record their digital play. Further, children were invited to build a toy they would like to be invented using LEGO bricks. Children were invited to create concept maps on a number of questions relating to play, technology and learning. In addition, the children were observed in schools using technology, and were also observed in a regular after-school club or community venue they visited. In each case, the child’s class teacher and the community/ after school club leader were interviewed. Finally, children in schools took part in focus group interviews in which they were invited to create collages, complete concept maps and build a toy they would like to be invented using LEGO bricks.<br>In this study, we started with 10 families (one family with twins) from 9 schools in the Cape Town area, that is, 11 case-study children (see Table 1), who were selected by the teachers and observed in school. After the school visits, one family (case-study child Fahiema) decided not to participate in the family visits part of the field work. The transcripts for each of the case-study children and the telephonic interviews of 30 parents on follow-up themes from the survey is shared. To protect identities of participants, pseudonyms are used.<br>The following qualitative data is shared: interviews with their teachers; focus-group discussions; community visits; family visits and telephonic parent interviews. <br>NOTE: The research instruments used in this study were adapted from Marsh, J. Stjerne Thomsen, B., Parry, B., Scott, F. Bishop, J.C., Bannister, C., Driscoll, A., Margary, T., Woodgate, A., (2019) Children, Technology and Play. UK Survey Questions. LEGO Foundation.<br>
DOI: 10.6084/m9.figshare.12017049.v1
title: Supplementary Table 1

description: <b>Supplementary Table 1. D</b><b>ifferentially expressed genes in patients with systemic sclerosis compared with controls. </b>ACA, anti-centromere antibody; ATA, anti-topoisomerase antibody; RNAP, anti-RNA polymerase 3 antibody; RNP, anti-U1RNP antibody.
DOI: 10.6084/m9.figshare.12017049.v2
title: Supplementary Table 1

description: <b>Supplementary Table 1. Cluster of genes in hierarchical clustering analysis. <br></b><b>Supplementary Table 2. Genes with adjusted p-value less than 0.05 compared with healthy controls. </b>ACA, anti-centromere antibody; ATA, anti-topoisomerase antibody; RNAP, anti-RNA polymerase 3 antibody; RNP, anti-U1RNP antibody.
DOI: 10.6084/m9.figshare.12017049.v3
title: Supplementary Table 1

description: <b>Supplementary Table 1. Cluster of genes in hierarchical clustering analysis. <br></b><b>Supplementary Table 2. Genes with adjusted p-value less than 0.05 compared with healthy controls. </b>ACA, anti-centromere antibody; ATA, anti-topoisomerase antibody; RNAP, anti-RNA polymerase 3 antibody; RNP, anti-U1RNP antibody.