cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.14797443.v1
title: Supplementary Material for: High Tissue TLR5 Expression Predicts Better Outcomes in Colorectal Cancer Patients

description: <b><i>Background:</i></b> Colorectal cancer (CRC), the third most common cancer globally, caused 881,000 cancer deaths in 2018. Toll-like receptors (TLRs), the primary sensors of pathogen-associated molecular patterns and damage-associated molecular patterns, activate innate and adaptive immune systems and participate in the development of an inflammatory tumor microenvironment. We aimed to explore the prognostic value of TLR3, TLR5, TLR7, and TLR9 tissue expressions in CRC patients. <b><i>Methods:</i></b> Using immunohistochemistry, we analyzed tissue microarray samples from 825 CRC patients who underwent surgery between 1982 and 2002 at the Department of Surgery, Helsinki University Hospital, Finland. After analyzing a pilot series of 205 tissue samples, we included only TLR5 and TLR7 in the remainder of the patient series. We evaluated the associations between TLR5 and TLR7 tissue expressions, clinicopathologic variables, and survival. Using the Kaplan-Meier method, we generated survival curves, determining significance using the log-rank test. Univariate and multivariate survival analyses relied on the Cox proportional hazards model. <b><i>Results:</i></b> The 5-year disease-specific survival was 55.9% among TLR5-negative (95% confidence interval [CI] 50.6–61.2%) and 61.9% (95% CI 56.6–67.2%; <i>p</i> = 0.011, log-rank test) among TLR5-positive patients. In the Cox multivariate survival analysis adjusted for age, sex, stage, location, and grade, positive TLR5 immunoexpression (hazard ratio [HR] 0.74; 95% CI 0.59–0.92; <i>p</i> = 0.007) served as an independent positive prognostic factor. TLR7 immunoexpression exhibited no prognostic value in the survival analysis across the entire cohort (HR 0.97; 95% CI 0.78–1.20; <i>p</i> = 0.754) nor in subgroup analyses. <b><i>Conclusions:</i></b> We show for the first time that a high TLR5 tumor tissue expression associates with a better prognosis in CRC patients.
DOI: 10.6084/m9.figshare.19773664.v1
title: Qualitative Transcripts

description: Qualitative Interview data for the research project titled, " Qualitative Exploration of the Psychological Dimensions of Telehealth Shared Medical Appointments (SMAs) for Buprenorphine Prescribing"
DOI: 10.17632/dr38z9kz2h
title: Evaluation of the accuracy from thermal imaging results in experimental tests when using 1 MHz therapeutic ultrasound

description: In therapeutic hyperthermia, one of the main concerns is the determination of tissue temperature with minimum delay. However, studies in this area started from the application of models like pence equation and reached to MRI application in hyperthermia thermometry. Some limitations, such as cost, time, and equipment, recent studies have gravitated to other methods such as Infra-red cameras. Due to the superficial nature of IR thermometry, the goal of this study was to investigate the temperature difference in different regions of tissue while utilizing continuous 1 MHz ultrasound waves at the power of 0.2 to 2 W. Ultrasound hyperthermia in this work was done on chicken breast. At power 2 W, a temperature difference above 8.5 ° C was recorded, which indicates an error above 50% in this thermography method. It was also shown that a high percentage of temperature changes happen at the beginning of irradiation. The results of this study showed that due to significant temperature differences, understanding of the relation between surface and deep tissue temperature could lead to a better and more accurate prediction.
DOI: 10.17632/ycy25jfk32
title: Supplementary Tables for Lei et al. (2023) submitted to Geophysical Research Letters

description: This file includes Supplementary Tables S1-S5 for: Lei, K., Wang, H., Wang, Y. L., Zhang, Q., & Li, X.-H. Decoupled Zircon Si–O Isotopes Tracing the Supracrustal Silicification and Komatiitic-derived Fluids in the Source of TTGs. Geophysical Research Letters, submitted in July 2023
DOI: 10.6084/m9.figshare.21559086.v1
title: C-GWAS application of human facial shape GWASs

description: This dataset is the summary statistics of combining GWASs (C-GWAS) of 78 public facial shape GWASs from our previous work (Xiong, Z.<em> et al.</em> Novel genetic loci affecting facial shape variation in humans. <em>Elife</em> <strong>8</strong>(2019)). Details of C-GWAS and data format can be refered to Methods section and Supplementary Data 2. See and cite publication <strong>Xiong et al. New Method for Combining Genome-wide Association Studies Highlights Novel Loci Involved in Human Facial Variation. </strong><em><strong>Nat Commun</strong></em> <strong>2022 upcoming.</strong>
DOI: 10.6084/m9.figshare.9785246.v1
title: Host tolerance and resistance to parasitic nest flies differs between two wild bird species

description: Data required to replicate the analyses in Grab et al. In press. Host tolerance and resistance to parasitic nest flies differs between two wild bird species. Ecology and Evolution
DOI: 10.17632/dgp2dryc86
title: Predictive Modeling and Mechanistic Validation of Synergistic Pimodivir Combinations for Anti-influenza therapy via PB2cap Affinity Enhancement

description: The rapid discovery of synergistic antiviral combinations remains a critical challenge in combating virus diseases. Here, we present a machine learning (ML) framework integrating drug characterization and cellular activity data to predict efficacious single and combinatorial therapies against influenza A. Our model identified pimodivir—a PB2 cap-binding inhibitor—paired with epinephrine bitartrate or L-adrenaline as top candidates, demonstrating broad-spectrum synergy against pandemic H1N1 and recent circulating bovine H5N1 viruses. Experimental validation revealed these combinations enhance pimodivir’s binding affinity to the PB2cap domain. Minigenome assays confirmed dose-dependent synergistic suppression of viral polymerase activity, despite neither adjuvant showing standalone efficacy. Multi-model synergy scoring methods (ZIP, Loewe, HSA, Bliss) and cytopathic effect profiling further validated the therapeutic potential of the selected drug combinations. Our findings offer a roadmap for rational combination therapy design against influenza and potential other RNA viruses.
DOI: 10.17632/jcms9rxc5g
title: Data for: Low-temperature preparation of humidity self-regulating porous ceramics with high strength performance

description: Effect of water content on the (a) flexural strength and (b) the bulk density of the specimens; Effect of drying time on the (c) flexural strength, linear shrinkage and (d) XR
DOI: 10.17632/psd4hn7htz
title: Data for: Sephadex filtration as successful alternative to density-gradient centrifugation procedures for ram sperm selection

description: Density-gradients centrifugation (DGC) and filtration columns (FC) are used in mammals in order to separate deficient or dead sperm, debris, and other cells than sperm which may negatively affect the fertilizing ability of spermatozoa in fresh, chilled and frozen/thawed semen. The present study was conducted to evaluate the suitability of DGC (BoviPure , Percoll and Accudenz ) and FC (Sephadex G-15 ) sperm selection procedures for fresh-extended and cold-stored ram semen by assessment of post-treatment sperm quality parameters. Twenty normospermic ejaculates from ten adult Merino rams were used. Sperm concentration of recovered spermatozoa was higher (P 0.001) after BoviPure treatment than other procedures in both fresh-extended and cold-stored semen. The Sephadex method showed more advantageous values than DGC procedures in several sperm motility variables measured by CASA system. In non-refrigerated semen samples, the percentage of progressive sperm motility (%PSM) after Sephadex filtration was higher (P 0.05) than after BoviPure treatment; the straight-line velocity (VSL) value after Sephadex filtration was higher (P 0.01) than after Accudenz treatment; the amplitude of lateral head displacement (ALH) after Sephadex and Accudenz treatment was lower than non-filtered semen (P 0.001) and after Percoll (P 0.01) and BoviPure (P 0.05) treatments. In cold-stores semen samples, the %PSM after Sephadex filtration was higher than non-filtered (P 0.05) semen and after BoviPure (P 0.05), Percoll (P 0.05) and Accudenz (P 0.001) treatments; the VSL (P 0.01) values after Accudenz treatment were lower (P&lt;0.01) than non-filtered semen and after other sperm selection methods treatments. The ALH after Sephadex and Accudenz treatments was lower (P&lt;0.01) than non-filtered semen. It is concluded that Sephadex columns filtration can be used to select ram spermatozoa in non-refrigerated and cooled semen, showing an advantage over the tested DGC methods as to percentage progressively motile sperm and sperm motility characteristics.
DOI: 10.6084/m9.figshare.28728782.v1
title: Light-regulated agonists spatiotemporally activating the Vitamin D receptor mitigate psoriasis-like inflammation in mice without inducing hypercalcemia

description: Data export from the software HDX Workbench in support of 4 differential HDX experiments:VDR+-Compound 11b_UVLightVDR+-Compound 11b_DarkVDR+-2148936_UVLightVDR+-2148936_Dark
DOI: 10.6084/m9.figshare.28814828.v1
title: Supporting information of the genome of <i>Eocanthecona furcellata</i>

description: This dataset includes the first chromosome-level genome assembly and annotation of the predatory stink bug <i>Eocanthecona furcellata</i>, generated using PacBio HiFi long-reads and Hi-C sequencing. It encompasses raw sequencing data, a high-quality genome assembly (1.065 Gb, 8 chromosomes), and comprehensive annotations of protein-coding genes (20,134), transposable elements (70.6% of the genome), and noncoding RNAs. Comparative genomic analyses with 12 other insect species (e.g., <i>Arma custos</i>, <i>Nezara viridula</i>)
DOI: 10.6084/m9.figshare.9631880.v1
title: EC9_B46.nwb

description: The enclosed data is collected using a high-density 256-channel electrocorticography array implanted in a human patient during treatment for epilepsy. The subjects are reading aloud consonant-vowel syllables from a list. The data was collected by Dr. Edward Chang at the University of California, San Francisco, and curated by Ben Dichter.<br>Data is organized by subject ID, and each file is a continuous recording session in Neurodata Without Borders: Neurophysiology (NWB:N) 2.0 format. Voltage traces are included for each of the recorded 256 channels. Microphone signal was recorded at the time but is removed for HIPAA compliance. Detailed hand-marked annotations are provided which mark what syllable was said, and the times of the start, consonant-vowel transition, and end of each syllable. A rest-period time is also included when the subject was silent, which can be used as a baseline. Hand-marked anatomical labels are included for electrodes in the relevant brain regions. All dates have been removed for HIPAA compliance and replaced with Jan 1, 1900.
DOI: 10.17632/kj8kzp8twn
title: Data for: Embedding Individualized Machine Learning Prediction Models for Energy Efficient VM Consolidation within Cloud Data Centers

description: The cross validation results for the prediction models.
DOI: 10.17632/yzbfm4v7y7
title: Identification of novel antiviral drug candidates using an optimized SARS-CoV-2 phenotypic screening platform. Bojkova et al

description: This table presents the results from a screen of kinase inhibitors for activity against a SARS-CoV-2 Delta isolate. Caco-2-F03 cells were infected with an MOI of 0.01 and virus infection was monitored using caspase 3/7 activity as read-out.
DOI: 10.6084/m9.figshare.27004153.v1
title: Groundwater Storage Anomaly derived from monitoring wells of the China National Groundwater Monitoring Project

description: Groundwater Storage Anomaly (GWSA) time series from 2018 to 2021 are derived using data from wells monitored under the China National Groundwater Monitoring Project. To account for the uneven spatial distribution of these wells, the Thiessen polygon method was applied to assign area-based weights to the GWSA, ensuring accurate representation of groundwater storage variations. The GWSA time series is presented in millimeters of equivalent water height.
DOI: 10.6084/m9.figshare.28190444.v2
title: S1.csv

description: Data
DOI: 10.17632/f4twnw8gy5
title: Data for: The NMDA receptor antagonist MK-801 fails to impair long-term recognition memory in mice when the state-dependency of memory is controlled

description: Chan et al. DATA FILE. Contains the relevant data for each animal analyses in the paper.
DOI: 10.6084/m9.figshare.23636252.v2
title: Enabling drip irrigation technology diffusion and adoption among African smallholders: a document analysis of climate action plans and donor projects

description: Drip irrigation can be a transformational technology for smallholders in Sub-Saharan Africa (SSA). However, the diffusion and adoption of drip irrigation remain limited due to the existence of key barriers, and use of drip irrigation has largely been confined to donor- and government-supported irrigation projects. This paper therefore investigates actions to overcome key barriers, with a focus on the role of donors in these efforts. Based on documentary analysis of, respectively, policy reports and the OECD’s database of bilateral aid, we construct a framework for measures that enable the diffusion and adoption of drip irrigation and then assess how bilateral aid organizations have taken part in these measures. Focusing on bilateral aid in the period 2013–2019, we show how a large share of projects, through support for smallholder irrigation schemes, have focused on increasing farmers’ technical skills and linking them with agricultural markets, as well as enhancing extension services and providing capacity-building for public institutions. However, these projects have paid less attention to improving the supply chains for irrigation equipment and farm inputs such as seeds and fertilizers. We therefore recommend that future donor interventions into drip irrigation apply system-oriented perspectives which consider markets conditions for finance and for agricultural inputs and outputs.
DOI: 10.17632/fz2dt9zzbm
title: effect of microbial inoculation on composting process: A meta-analysis

description: Microbial inoculants have been promoted as a strategy to improve compost quality, but general conclusion is hardly be drawn on this topic due to considerable variation between the published studies. This database therefore contains all the necessary information which was used to performed a meta-analysis to estimate the overall effect size of microbial inoculants on carbon, nitrogen, C/N ratio, phosphorus, potassium, pH, germination index, cellulose, hemicellulose, lignin and humus contents. In addition, this database is used to perform a meta-regression and moderator analyses to determine abiotic and biotic factors influencing the efficacy of microbial inoculants. List of references which are used to perform the meta-analysis are also included in the database. Using this database, we performed a meta-analysis and found out that the beneficial effects of microbial inoculants on total nutrient content, lignocellulose degradation and degree of humification. The microbial inoculant effect size was marginal for bioavailable forms of nitrogen and phosphorus. The microbial inoculants efficiency varies between inoculant forms, inoculation time, composting method and experimental duration, but the effect of feedstock type and experimental scale is limited.
DOI: 10.17632/3yp272r56z
title: Reform in the healthcare system in Albania and salary increase for nurses: a perspective on integration into the European Union

description: This material examines the reforms in Albania's healthcare system, particularly the improvement of nurse training and salary increases post-pandemic. By emphasizing the importance of nurses in providing healthcare and the need to align with European standards, this study analyzes the challenges and opportunities for improving the Albanian healthcare system in the context of integration into the European Union.
DOI: 10.17632/bjf5f5zkwh
title: Database considering the employment and establishments in the municipalities of the State of Mato Grosso do Sul  

description: Database considering the employment (file 1) and the establishments (file 2) in the municipalities of the State of Mato Grosso do Sul for the year 2020. 
The spatially weighted Composite Concentration Index (ICCs) was calculated, considering its formation of the levels of productive specialization(QLs), competitive concentration (HHms) and relative participation (PRs). The ICCs was calculated considering the municipal spatial scale listed for the following sectors: Industry ICCs1, Construction ICCs2, Trade ICCs3, Services ICC4 and Farming  ICCs5.
DOI: 10.17632/z6gb952vwd
title: Therapeutic advantages of combined gene/cell therapy strategies in a murine model of GM2 gangliosidosis

description: Genetic deficiency of β-N-acetylhexosaminidase (Hex) functionality leads to accumulation of GM2 ganglioside in Tay-Sachs disease and Sandhoff disease (SD), which presently lack approved therapies. Current experimental gene therapy (GT) approaches with adeno-associated viral vectors (AAVs) still pose safety and efficacy issues, supporting the search for alternative therapeutic strategies. Here we leveraged the lentiviral vector (LV)-mediated intracerebral (IC) GT platform to deliver Hex genes to the CNS and combined this strategy with bone marrow transplantation (BMT) to provide a timely, pervasive, and long-lasting source of the Hex enzyme in the CNS and periphery of SD mice. Combined therapy outperformed individual treatments in terms of lifespan extension and normalization of the neuroinflammatory/neurodegenerative phenotypes of SD mice. These benefits correlated with a time-dependent increase in Hex activity and a remarkable reduction in GM2 storage in brain tissues that single treatments failed to achieve. Our results highlight the synergic mode of action of LV-mediated IC GT and BMT, clarify the contribution of treatments to the therapeutic outcome, and inform on the realistic threshold of corrective enzymatic activity. These results have important implications for interpretation of ongoing experimental therapies and for design of more effective treatment strategies for GM2 gangliosidosis.
DOI: 10.17632/bd25tf499w
title: A data set regarding the application of artificial intelligence technology in gastroenterology

description: Artificial intelligence (AI) has been widely used in the field of medicine. Therefore, it can potentially be used for the inspection and diagnosis of gastrointestinal diseases. Herein, we summarized past research on AI and reviewed the challenges faced and future development opportunities associated with the application of AI in gastrointestinal diseases.Therefore, we here collected 17,758 data on AI techniques to identify and diagnose 13 common digestive disorders.
DOI: 10.17632/t47tw94mzd
title: Athlete and physiotherapists experiences of pain and pain assessment - A Data set of focus group transcripts

description: This data set comprises 5 focus groups with 16 participants in total. (12 athletes 4 physiotherapists). The focus groups explored athlete pain and pain assessment experiences and priorities for future pain assessment practice. The topic guide used is included at the bottom of the data set file.
DOI: 10.17632/d8fh6ty4mh
title: Data from Complex Network Representation of the Structure–Mechanical Property Relationships in Elastomers with Heterogeneous Connectivity

description: This data set was prepared for a paper entitled "Complex Network Representation of the Structure–Mechanical Property Relationships in Elastomers with Heterogeneous Connectivity". It contains the simulation data, and intermediate data with script files to draw main figures. The simulation data was obtained and analyzed using J-OCTA V5.0 with COGNAC 9.2.2. The intermediate data was obtained from the simulation data using COGNAC 9.2.2 or python 3.7.0. The script file could be executed in python3 with some libraries to draw main figures in the paper.
DOI: 10.17632/n4kvzzwsvy
title: Data for: TiO2 nanopowder as a high rate, long cycle life electrode in aqueous aluminium electrolyte

description: Supporting data for TiO2 nanopowder as a high rate, long cycle life electrode in aqueous aluminium electrolyte.
DOI: 10.6084/m9.figshare.26800249.v1
title: Fluorescence In Situ Hybridization Microscopy images of novel Mollicutes in Callogorgia delta

description: Fluorescence In Situ Hybridization microscopy images of novel Mollicutes, Oceanoplasmataceae, in the deep-sea coral, Callogorgia delta. See publication in Nature Communications for methodological details: "Discovery of deep-sea coral symbionts from a novel clade of marine bacteria with severely reduced genomes". Images are grouped in folders by coral colony (Ex: T4-4) which appears at the beginning of the folder name. See supplementary information in publication for metadata associated with these colonies.
DOI: 10.17632/yvm7ttkfz8
title: QRL MODEL FOR ELECTROLYTE SOLUTIONS. Theory and computational methods. An example of software implementation.

description: The most recent publication concerned with the Quasi-Random Lattice (QRL) Model and its application to electrolyte solutions is now available at https://doi.org/10.1016/j.fluid.2024.114243
Temporary share link https://authors.elsevier.com/a/1jtWx1M2A%7ESaAC

The Supplementary Information includes a software version (MATLAB code) implementing computational methods and procedures connected with QRL theory and equations.

The code is cast into four modules, each of them is a stand-alone module.
The examplifying case considered is aqueous HCl at 25°C. 
Short overview of the code (currently present in the Supporting Information, https://doi.org/10.1016/j.fluid.2024.114243)
 - Module "Power_Series_Density_HCl_25.m"
 Implementation of the procedure to calculate solution density and apparent 
 molar volume of solute from 0 to 8 mol/kg; the calibration set (experimental
 densities used) refers to molalities within 1-3 mol/kg (about).
 - Module "cL_Parameterization_HCl_25.m"
 Calculation of mean activity / osmotic coefficient from 0 to 1.88 mol/kg 
 after determining the main QRL parameterization (cL) by means of experimental osmotic data (at molalities 1, 1.5, 2, 2.5 mol/kg). 
- Module "dcL_dP_Parameterization_HCl_25.m"
 Computation of the pressure derivative (dcL_dP) of the cL parameterization and further quantities propeduetical to next module.
- Module "QRL_Extended_Parameterization_HCl_25.m"
 Implementation of the procedure to calculate mean activity coefficient, osmotic coefficient, (Abelian) solution density and apparent molar volume of solute for molalities from 1.88 to 16 mol/kg; the calibration set (experimental density and experimental osmotic data used in addition to previous ones) refers to 16 mol/kg (about).