DOI: 10.5281/zenodo.5503751
title: Immune signatures predict development of autoimmune toxicity in immune checkpoint inhibitor-treated patients with cancer

description: <strong>Immune signatures predict development of autoimmune toxicity in immune</strong><strong> checkpoint inhibitor-treated patients with cancer</strong> Nicolas Gonzalo Nuñez<sup>1</sup>*, Fiamma Berner<sup>2</sup>*, Ekaterina Friebel<sup>1</sup>*, Susanne Unger<sup>1</sup>, Nina Wyss<sup>2,3</sup>, Julia Martinez Gomez<sup>4</sup>, Mette-Triin Purde<sup>2</sup>, Rebekka Niederer<sup>2,3</sup>, Maximilian Porsch<sup>5</sup>, Christa Lichtensteiger<sup>2</sup>, Rafaela Kramer<sup>6</sup>, Michael Erdmann<sup>6</sup>, Christina Schmitt<sup>7</sup>, Lucy Heinzerling<sup>6,7</sup>, Marie-Therese Abdou<sup>2</sup>, Julia Karbach<sup>8</sup>, Dirk Schadendorf<sup>9</sup>, Lisa Zimmer<sup>9</sup>, Selma Ugurel<sup>9</sup>, Niklas Klümper<sup>10,11,12</sup>, Michael Hölzel<sup>10,11</sup>, Laura Power<sup>1</sup>, Stefanie Kreutmair<sup>1</sup>, Mariaelena Capone<sup>13</sup>, Gabriele Madonna<sup>13</sup>, Lacin Cevhertas<sup>14,15</sup>, Anja Heider<sup>14</sup>, Teresa Amaral<sup>16,17</sup>, Omar Hasan Ali<sup>2,3,4,18</sup>, David Bomze<sup>2,19</sup>, Florentia Dimitriou<sup>4</sup>, Stefan Diem<sup>20</sup>, Paolo Antonio Ascierto<sup>13</sup>, Reinhard Dummer<sup>4</sup>, Elke Jäger<sup>8</sup>, Christoph Driessen<sup>20</sup>, Mitchell P. Levesque<sup>4</sup>, Willem van de Veen<sup>14</sup>, Markus Joerger<sup>20</sup>, Martin Früh<sup>20,21</sup>, Burkhard Becher<sup>1</sup>**, Lukas Flatz<sup>2,3,4,20,22</sup>** */** these authors contributed equally Affiliations 1. Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland 2. Institute of Immunobiology, Medical Research Center, Kantonsspital St. Gallen, St.Gallen, Switzerland 3. Department of Dermatology, Kantonsspital St. Gallen, St.Gallen, Switzerland 4. Department of Dermatology, University Hospital Zurich, Zurich, Switzerland 5. Department of Radiology, Kantonsspital St. Gallen, St.Gallen, Switzerland 6. Department of Dermatology, University of Erlangen-Nuremberg, Erlangen, Germany 7. Ludwig Maximilian University of Munich, Munich, Germany 8. Department of Oncology and Hematology, Krankenhaus Nordwest, Frankfurt, Germany 9. Department of Dermatology, Comprehensive Cancer Center (Westdeutsches Tumorzentrum) University Hospital Essen, Essen, Germany 10. Institute for Experimental Oncology, University Hospital Bonn, Bonn, Germany 11. Center for Integrated Oncology Cologne/Bonn, University Hospital Bonn, Bonn, Germany 12. Department of Urology, University Hospital Bonn, Bonn, Germany 13. Istituto Nazionale Tumori-IRCCS-Fondazione G. Pascale, Napoli, Italy 14. Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland 15. Department of Medical Immunology, Institute of Health Sciences, Bursa Uludag University, Bursa, Turkey 16. Skin Cancer Center, Department of Dermatology, University Hospital Tübingen, Tübingen, Germany 17. iFIT Cluster of Excellence (EXC 2180), University of Tübingen, Tübingen, Germany 18. Department of Medical Genetics, Life Sciences Institute, University of British Columbia, Vancouver, Canada 19. Sackler Faculty of Medicine, Tel-Aviv University, Israel 20. Department of Oncology, Kantonsspital St. Gallen, St.Gallen, Switzerland 21. Department of Medical Oncology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland 22. Universitäts-Hautklinik, University of Tübingen, Tübingen, Germany