cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.12859657.v1
title: 1-Deoxysphingolipids cause autophagosome and lysosome accumulation and trigger NLRP3 inflammasome activation

description: 1-Deoxysphingolipids (deoxySLs) are atypical sphingolipids of clinical relevance as they are elevated in plasma of patients suffering from hereditary sensory and autonomic neuropathy (HSAN1) or type 2 diabetes. Their neurotoxicity is described best but they inflict damage to various cell types by an uncertain pathomechanism. Using mouse embryonic fibroblasts and an alkyne analog of 1-deoxysphinganine (doxSA), the metabolic precursor of all deoxySLs, we here study the impact of deoxySLs on macroautophagy/autophagy, the regulated degradation of dysfunctional or expendable cellular components. We find that deoxySLs induce autophagosome and lysosome accumulation indicative of an increase in autophagic flux. The autophagosomal machinery targets damaged mitochondria that have accumulated N-acylated doxSA metabolites, presumably deoxyceramide and deoxydihydroceramide, and show aberrant swelling and tubule formation. Autophagosomes and lysosomes also interact with cellular lipid aggregates and crystals that occur upon cellular uptake and N-acylation of monomeric doxSA. As crystals entering the lysophagosomal apparatus in phagocytes are known to trigger the NLRP3 inflammasome, we also treated macrophages with doxSA. We demonstrate the activation of the NLRP3 inflammasome by doxSLs, prompting the release of IL1B from primary macrophages. Taken together, our data establish an impact of doxSLs on autophagy and link doxSL pathophysiology to inflammation and the innate immune system. <b>Abbreviations</b>: alkyne-doxSA: (2S,3R)-2-aminooctadec-17yn-3-ol; alkyne-SA: (2S,3R)-2- aminooctadec-17yn-1,3-diol; aSA: alkyne-sphinganine; ASTM-BODIPY: azido-sulfo-tetramethyl-BODIPY; CerS: ceramide synthase; CMR: clonal macrophage reporter; deoxySLs: 1-deoxysphingolipids; dox(DH)Cer: 1-deoxydihydroceramide; doxCer: 1-deoxyceramide; doxSA: 1-deoxysphinganine; FB1: fumonisin B1; HSAN1: hereditary sensory and autonomic neuropathy type 1; LC3: MAP1LC3A and MAP1LC3B; LPS: lipopolysaccharide; MEF: mouse embryonal fibroblasts; MS: mass spectrometry; N<sub>3</sub>635P: azido-STAR635P; N<sub>3</sub>Cy3: azido-cyanine 3; N<sub>3</sub>picCy3: azido-picolylcyanine 3; NLRP3: NOD-like receptor pyrin domain containing protein 3; P4HB: prolyl 4-hydroxylase subunit beta; PINK1: PTEN induced putative kinase 1; PYCARD/ASC: PYD and CARD domain containing; SPTLC1: serine palmitoyltransferase long chain base subunit 1; SQSTM1: sequestosome 1; TLC: thin layer chromatography.
DOI: 10.6084/m9.figshare.16528806.v1
title: Additional file 16 of Circ-GALNT16 restrains colorectal cancer progression by enhancing the SUMOylation of hnRNPK

description: Additional file 16: Table S6. The mRNA sequencing results constructed in circ-GALNT16 overexpression and control RKO cells.
DOI: 10.17632/6br2sg4mx4.1
title: Study of Residual Alkyl Halide Determinations via Conversion to Alkyl Chlorides

description: This is the complete dataset used to study a new methodology for the determination of residual alkyl iodides and alkyl bromides via conversion to their corresponding alkyl chlorides when analyzed using standard headspace GC methodology.
DOI: 10.17632/6br2sg4mx4.2
title: Study of Residual Alkyl Halide Determinations via Conversion to Alkyl Chlorides

description: This is the complete dataset used to study a new methodology for the determination of residual alkyl iodides and alkyl bromides via conversion to their corresponding alkyl chlorides when analyzed using standard headspace GC methodology.
DOI: 10.6084/m9.figshare.12859672
title: A Co(II)-based coordination polymer: inhibitory activity on cervical cancer cells

description: By using a mixed-ligand approach, a new Co(II)-bearing coordination polymer (CP) with the chemical formula of [{Co(BINDI)<sub>0.5</sub>(bpa)<sub>0.5</sub>(H<sub>2</sub>O)}·4H<sub>2</sub>O]<i><sub>n</sub></i> (<b>1</b>, H<sub>4</sub>BINDI = <i>N</i>,<i>N</i>′-bis(5-isophthalic acid)naphthalenediimide, bpa = 1,2-bis(4-pyridyl)ethane) has been synthesized by room temperature self-assembly and structurally characterized successfully. Furthermore, a process of sonochemistry with oleic acid treatment at 453 K was used to produce the nanostructure <b>1</b> (denoted as nano <b>1</b> hereafter). The inhibitory effect of nano <b>1</b> on cervical cancer cells was determined. Firstly, the CCK-8 assay was performed. The Reverse Transcription Polymerase Chain Reaction (RT-PCR) assay was performed and the relative expression levels of miR-16-1 were determined. Then, the western blotting detection was conducted and the Bcl-2 expression level after nano <b>1</b> treatment was evaluated.
DOI: 10.6084/m9.figshare.12859672.v1
title: A Co(II)-based coordination polymer: inhibitory activity on cervical cancer cells

description: By using a mixed-ligand approach, a new Co(II)-bearing coordination polymer (CP) with the chemical formula of [{Co(BINDI)<sub>0.5</sub>(bpa)<sub>0.5</sub>(H<sub>2</sub>O)}·4H<sub>2</sub>O]<i><sub>n</sub></i> (<b>1</b>, H<sub>4</sub>BINDI = <i>N</i>,<i>N</i>′-bis(5-isophthalic acid)naphthalenediimide, bpa = 1,2-bis(4-pyridyl)ethane) has been synthesized by room temperature self-assembly and structurally characterized successfully. Furthermore, a process of sonochemistry with oleic acid treatment at 453 K was used to produce the nanostructure <b>1</b> (denoted as nano <b>1</b> hereafter). The inhibitory effect of nano <b>1</b> on cervical cancer cells was determined. Firstly, the CCK-8 assay was performed. The Reverse Transcription Polymerase Chain Reaction (RT-PCR) assay was performed and the relative expression levels of miR-16-1 were determined. Then, the western blotting detection was conducted and the Bcl-2 expression level after nano <b>1</b> treatment was evaluated.
DOI: 10.6084/m9.figshare.14431549.v3
title: Additional file of LncRNA XIST upregulates TRIM25 via negatively regulating miR-192 in hepatitis B virus-related hepatocellular carcinoma

description: Additional file of LncRNA XIST upregulates TRIM25 via negatively regulating miR-192 in hepatitis B virus-related hepatocellular carcinoma
DOI: 10.6084/m9.figshare.12859708.v1
title: Late Cretaceous adakitic rocks from the western Tibetan Plateau: implications for the subduction of the Neo-Tethys Ocean

description: It is still hotly debated whether the subduction of the Indus-Yarlung Zangbo Tethyan oceanic lithosphere led to Cretaceous magmatism in the north Lhasa terrane or not. Here, we provide new data on adakitic dacite in the Rutog area, western Tibetan Plateau. Zircon U-Pb dating and Lu-Hf analyses yielded a weighted-mean <sup>206</sup>Pb/<sup>238</sup>U age of <i>ca</i>. 97 Ma for a dacite sample, and corresponding positive zircon ε<sub>Hf</sub>(<i>t</i>) values of +5.3 to +10.1. All samples have high Sr (796–1091ppm), but low Y (10.4–11.9 ppm) and Yb (0.68–0.79 ppm) contents, with pronounced high Sr/Y (72.5–97.6) ratios. Furthermore, they have low K<sub>2</sub>O (1.11–1.49 wt.%) and Th (4.18–4.54 ppm) contents, and low K<sub>2</sub>O/Na<sub>2</sub>O (0.18–0.28) and Th/La (0.22–0.24) ratios. These geochemical features are most simialr to those of adakite derived from partial melting of subducted oceanic slab. These new data, in combination with regional geology, enable us to suggest that the Late Cretaceous arc-affinity magmatic rocks were probably triggered by northward subduction of the Indus-Yarlung Zangbo oceanic lithosphere. This will give new insights into the geodynamic evolution of the Indus-Yarlung Zangbo Neo-Tethys Ocean.
DOI: 10.6084/m9.figshare.14431549
title: Additional file of LncRNA XIST upregulates TRIM25 via negatively regulating miR-192 in hepatitis B virus-related hepatocellular carcinoma

description: Additional file of LncRNA XIST upregulates TRIM25 via negatively regulating miR-192 in hepatitis B virus-related hepatocellular carcinoma
DOI: 10.6084/m9.figshare.14431549.v1
title: Additional file of LncRNA XIST upregulates TRIM25 via negatively regulating miR-192 in hepatitis B virus-related hepatocellular carcinoma

description: Additional file of LncRNA XIST upregulates TRIM25 via negatively regulating miR-192 in hepatitis B virus-related hepatocellular carcinoma
DOI: 10.6084/m9.figshare.14432072.v1
title: Additional file of Circular RNA circCSPP1 knockdown attenuates doxorubicin resistance and suppresses tumor progression of colorectal cancer via miR-944/FZD7 axis

description: Additional file of Circular RNA circCSPP1 knockdown attenuates doxorubicin resistance and suppresses tumor progression of colorectal cancer via miR-944/FZD7 axis
DOI: 10.6084/m9.figshare.14955867
title: Additional file 4 of Epidemiological and genomic characteristics of Acinetobacter baumannii from different infection sites using comparative genomics

description: Additional file 4:
DOI: 10.6084/m9.figshare.14432288
title: Additional file 1 of A signature of seven immune‐related genes predicts overall survival in male gastric cancer patients

description: Additional file 1. The detail of risk score for each male GC patient in TCGA dataset.
DOI: 10.6084/m9.figshare.12858732.v1
title: Additional file 2 of Third-generation sequencing found LncRNA associated with heat shock protein response to heat stress in Populus qiongdaoensis seedlings

description: Additional file 2 Table S1. Top 10 plant species compared according to the NR database. Table S2. Read count of known miRNA-mature leaves. Table S3. Base type of each position of the known miRNA. Table S4. Read count of novel miRNA-mature leaves. Table S5. Base type of each position of the novel miRNA. Table S6. Mapping of Illumina sequencing reads and reference reads. Table S7. Classification of lncRNA predicted under heat stress in P. qiongdaoensis.
DOI: 10.6084/m9.figshare.14956011
title: Additional file 2 of DNA methylation under the major depression pathway predicts pediatric quality of life four-month post-pediatric mild traumatic brain injury

description: Additional file 2. Genes and CpG sites included.
DOI: 10.6084/m9.figshare.12858860.v1
title: Additional file 2 of HDNA methylation data-based molecular subtype classification related to the prognosis of patients with hepatocellular carcinoma

description: Additional file 2: Table S2. HCC RNA-Seq data from TCGA database. RNA-Seq data included 424 HCC samples.
DOI: 10.6084/m9.figshare.12858872
title: Additional file 6 of HDNA methylation data-based molecular subtype classification related to the prognosis of patients with hepatocellular carcinoma

description: Additional file 6: Table S6. Differentially expressed sites were analysed by multivariate Cox model. A total of 10,699 significant methylation sites were obtained by multivariate Cox proportional hazards regression model analysis, with the T, N and M stages as the covariants in the model.
DOI: 10.6084/m9.figshare.14955957.v1
title: Additional file 2 of Characterization of TGFβ-associated molecular features and drug responses in gastrointestinal adenocarcinoma

description: Additional file 2. Molecular characterization of TGF-beta in GIACs.
DOI: 10.6084/m9.figshare.12858875.v1
title: Additional file 7 of HDNA methylation data-based molecular subtype classification related to the prognosis of patients with hepatocellular carcinoma

description: Additional file 7: Table S7. Identifying the methylation-based molecular subtypes. To identify methylation-based molecular subtype sites, the obtained 10,699 × 6 matrix was used as the input data of EpiDiff software.
DOI: 10.6084/m9.figshare.14955870.v1
title: Additional file 5 of Epidemiological and genomic characteristics of Acinetobacter baumannii from different infection sites using comparative genomics

description: Additional file 5:
DOI: 10.17632/27c6d6xthp.2
title: Tribometer pin-on-disc: Cr100 sphere against lead cast bronze coated disc

description: Seven pin-on-disc tests performed between Cr100 sphere (9.52mm diameter) and SAE 1015 steel–AMS 5060 discs with cast lead bronze (22-27 % Pb, 3-4 %
Sn and Cu remaining part) coating. Dry conditions. Room ambient control: 23 °C and 50% (rel. humidity). Track radius, sliding speed, sliding distance are all indicated in the file name. "GROUNDSURF" files correspond to freshly ground coating without any presence of copper oxide. Normal load on all tests: 10 N reference mantained with a PID controller acting on the Z displacement of the tribometer.

Files contain data on: tangential force (Fx), normal force (Fn), coefficient of friction (COF), wear depth (Z depth), timestep.

Tests performed on MFT-5000 multi function tribometer.


Financed by the European Union - NextGenerationEU (National Sustainable Mobility Center CN00000023, Italian Ministry of University and Research Decree n.
1033 - 17/06/2022, Spoke 11 - Innovative Materials & Lightweighting). The opinions expressed are those of the authors only and should not be considered as
representative of the European Union or the European Commission’s official position. Neither the European Union nor the European Commission can be held
responsible for them.
DOI: 10.17632/27c6d6xthp.1
title: Tribometer pin-on-disc: Cr100 sphere against lead cast bronze coated disc

description: Seven pin-on-disc tests performed between Cr100 sphere (9.52mm diameter) and SAE 1015 steel–AMS 5060 discs with cast lead bronze (22-27 % Pb, 3-4 %
Sn and Cu remaining part) coating. Dry conditions. Room ambient control: 23 °C and 50% (rel. humidity). Track radius, sliding speed, sliding distance are all indicated in the file name. "GROUNDSURF" files correspond to freshly ground coating without any presence of copper oxide. Normal load on all tests: 10 N reference mantained with a PID controller acting on the Z displacement of the tribometer.

Files contain data on: tangential force (Fx), normal force (Fn), coefficient of friction (COF), wear depth (Z depth), timestep.

Tests performed on MFT-5000 multi function tribometer.
DOI: 10.6084/m9.figshare.14432132.v1
title: Additional file of High expression of CDCA7 predicts poor prognosis for clear cell renal cell carcinoma and explores its associations with immunity

description: Additional file of High expression of CDCA7 predicts poor prognosis for clear cell renal cell carcinoma and explores its associations with immunity
DOI: 10.6084/m9.figshare.14432048
title: Additional file 2 of Gut microbiota composition and functional prediction in diarrhea-predominant irritable bowel syndrome

description: Additional file 2: Table S2. OTUs of two groups.
DOI: 10.6084/m9.figshare.14432558.v1
title: Additional file 2 of Non-invasive lung cancer diagnosis and prognosis based on multi-analyte liquid biopsy

description: Additional file 2: Supplementary Tables.
DOI: 10.6084/m9.figshare.14432291
title: Additional file 2 of A signature of seven immune‐related genes predicts overall survival in male gastric cancer patients

description: Additional file 2. The detail of risk score for each male GC patient in GSE15460.
DOI: 10.6084/m9.figshare.14432558
title: Additional file 2 of Non-invasive lung cancer diagnosis and prognosis based on multi-analyte liquid biopsy

description: Additional file 2: Supplementary Tables.
DOI: 10.17632/6br2sg4mx4.3
title: Study of Residual Alkyl Halide Determinations via Conversion to Alkyl Chlorides

description: This is the complete dataset used to study a new methodology for the determination of residual alkyl iodides and alkyl bromides via conversion to their corresponding alkyl chlorides when analyzed using standard headspace GC methodology.
DOI: 10.6084/m9.figshare.14432087.v2
title: Additional file of TMEFF2 promoter hypermethylation is an unfavorable prognostic marker in gliomas

description: Additional file of TMEFF2 promoter hypermethylation is an unfavorable prognostic marker in gliomas
DOI: 10.6084/m9.figshare.12858732
title: Additional file 2 of Third-generation sequencing found LncRNA associated with heat shock protein response to heat stress in Populus qiongdaoensis seedlings

description: Additional file 2 Table S1. Top 10 plant species compared according to the NR database. Table S2. Read count of known miRNA-mature leaves. Table S3. Base type of each position of the known miRNA. Table S4. Read count of novel miRNA-mature leaves. Table S5. Base type of each position of the novel miRNA. Table S6. Mapping of Illumina sequencing reads and reference reads. Table S7. Classification of lncRNA predicted under heat stress in P. qiongdaoensis.
DOI: 10.6084/m9.figshare.14432006
title: Additional file 3 of CircNEIL3 regulatory loop promotes pancreatic ductal adenocarcinoma progression via miRNA sponging and A-to-I RNA-editing

description: Additional file 3: Table S3. Antibodies used in the present study.
DOI: 10.6084/m9.figshare.14432009
title: Additional file 4 of CircNEIL3 regulatory loop promotes pancreatic ductal adenocarcinoma progression via miRNA sponging and A-to-I RNA-editing

description: Additional file 4: Table S4. 95 candidate miRNAs binding to circNEIL3 predicted by cross-analyzing three miRNA target prediction databases.
DOI: 10.6084/m9.figshare.14432084
title: Additional file 1 of TMEFF2 promoter hypermethylation is an unfavorable prognostic marker in gliomas

description: Additional file 1. Supplementary Metierial 1 (TableS1–S6 and Fig S1)
DOI: 10.6084/m9.figshare.14432000
title: Additional file 1 of CircNEIL3 regulatory loop promotes pancreatic ductal adenocarcinoma progression via miRNA sponging and A-to-I RNA-editing

description: Additional file 1: Table S1. The original sequencing results of all differentially expressed circRNAs in three pairs of PDAC and adjacent normal tissues.
DOI: 10.17632/bv6nxvfxcz.1
title: Innovation and Waste Disposal Italian Metropolitan Areas

description: Patents and Waste Disposal for 106 Italian Metropolitan Areas over a period of 20 years (2001-2020)
DOI: 10.6084/m9.figshare.14432084.v1
title: Additional file 1 of TMEFF2 promoter hypermethylation is an unfavorable prognostic marker in gliomas

description: Additional file 1. Supplementary Metierial 1 (TableS1–S6 and Fig S1)
DOI: 10.6084/m9.figshare.14955957
title: Additional file 2 of Characterization of TGFβ-associated molecular features and drug responses in gastrointestinal adenocarcinoma

description: Additional file 2. Molecular characterization of TGF-beta in GIACs.
DOI: 10.6084/m9.figshare.19151059
title: Additional file 1 of Motivations and future plans of the final year students in a Chinese dental school

description: Additional file 1.
DOI: 10.6084/m9.figshare.14432132
title: Additional file of High expression of CDCA7 predicts poor prognosis for clear cell renal cell carcinoma and explores its associations with immunity

description: Additional file of High expression of CDCA7 predicts poor prognosis for clear cell renal cell carcinoma and explores its associations with immunity
DOI: 10.6084/m9.figshare.14432159
title: Additional file of Exosomal miR-335 derived from mature dendritic cells enhanced mesenchymal stem cell-mediated bone regeneration of bone defects in athymic rats

description: Additional file of Exosomal miR-335 derived from mature dendritic cells enhanced mesenchymal stem cell-mediated bone regeneration of bone defects in athymic rats
DOI: 10.6084/m9.figshare.14956011.v1
title: Additional file 2 of DNA methylation under the major depression pathway predicts pediatric quality of life four-month post-pediatric mild traumatic brain injury

description: Additional file 2. Genes and CpG sites included.
DOI: 10.6084/m9.figshare.14432066
title: Additional file 8 of Gut microbiota composition and functional prediction in diarrhea-predominant irritable bowel syndrome

description: Additional file 8: Table S8. Predicted metagenomes KEGG at L3.
DOI: 10.34740/kaggle/ds/5607552
title: Formasi CASN 2024 S1 Teknologi Pendidikan
DOI: 10.15468/dl.kf3s4n
title: Occurrence Download

description: A dataset containing 1829 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is Ecuador",
 "TaxonKey is Tapirus pinchaque (Roulin, 1829)"
 ]
}

 The dataset includes 1829 records from 18 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0106264-240626123714530/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.25574/01055
title: Chandra X-ray Observatory ObsId 01055
DOI: 10.15468/dl.6hf4s7
title: Occurrence Download

description: A dataset containing 3510 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Nothoscordum gracile (Aiton) Stearn"
 ]
}

 The dataset includes 3510 records from 240 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0106265-240626123714530/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.5281/zenodo.12684768
title: Unlocking hidden mineral resources: Characterization and potential of bitterns as alternative sources of critical raw materials_dataset
DOI: 10.5281/zenodo.12684769
title: Unlocking hidden mineral resources: Characterization and potential of bitterns as alternative sources of critical raw materials_dataset
DOI: 10.15468/dl.kecdhx
title: Occurrence Download

description: A dataset containing 385681365 species occurrences available in GBIF matching the query:
{
 "and" : [
 {
 "or" : [
 "TaxonKey is Plantae",
 "TaxonKey is Animalia"
 ]
 },
 "HasCoordinate is true",
 "Year is greater than or equal to 1970"
 ]
}

 The dataset includes 385681365 records from 5432 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0000129-150523225239109/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.7wf4ky
title: Occurrence Download

description: A dataset containing 34 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Vachellia farnesiana (L.) Wight & Arn., Adenanthera pavonina L., Bacopa monnieri (L.) Pennell, Casuarina equisetifolia L., Cedrela odorata L., Chromolaena odorata (L.) R.M.King & H.Rob., Halophila stipulacea (Forssk.) Asch., Heliotropium curassavicum L., Leucaena leucocephala (Lam.) de Wit, Dolichandra unguis-cati (L.) L.G.Lohmann, Melaleuca quinquenervia (Cav.) S.T.Blake, Miconia calvescens DC., Psidium guajava L., Tabebuia heterophylla (DC.) Britton)",
 "BasisOfRecord is one of (Specimen, Human Observation, Observation, Living Specimen, Machine Observation, Literature Occurrence)",
 "Country is one of (Grenada)",
 "HasCoordinate is true",
 "HasGeospatialIssue is false"
 ]
}

 The dataset includes 34 records from 7 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0021812-250402121839773/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.xseaez
title: Occurrence Download

description: A dataset containing 13 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is Thailand",
 "TaxonKey is Eriocaulon echinulatum Mart."
 ]
}

 The dataset includes 13 records from 3 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0007612-181108115102211/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.qpyp1s
title: Occurrence Download

description: A dataset containing 123 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Lepus sinensis Gray, 1832"
 ]
}

 The dataset includes 123 records from 11 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0000839-150330110031120/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.