cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.30170959
title: Supplementary Material for: Phoxilium® as a Phosphate-Sparing Solution for Continuous Renal Replacement Therapy in Paracetamol-Induced Acute Liver Failure

description: Background: Hypophosphatemia is common in Acute Liver Failure (ALF) and may worsen during continuous renal replacement therapy (CRRT) with phosphate-free fluids. We aimed to evaluate the safety and efficacy of Phoxilium®, a phosphate-containing CRRT fluid.
Methods: We conducted a retrospective single-centre cohort study of paracetamol-induced ALF patients treated with CRRT between as our ICU transitioned from Accusol® to Phoxilium®. We obtained data on demographics, biochemistry, and outcomes. We compared biochemical variables every 6 hours up to 48 hours post-CRRT initiation and then every 12 hours until 168 hours. The primary outcome was the occurrence of severe hypophosphatemia (&lt; 0.32 mmol/L).
Results: In 38 ALF patients (Phoxilium®=14 and Accusol®=24). Phoxilium® was associated with elimination of severe hypophosphatemia (0% vs. 38%; p=0.014), a reduction in its median burden (proportion of phosphate readings &lt; 0.81 mmol/L: 13% [IQR; 2–33%] vs. 44% [29–51%]; p=0.001), and significantly lower phosphate supplementation requirements (median, 45 mmol [20–70 mmol] vs. 100 mmol [60–210 mmol]; p=0.008). Phoxilium® patients experienced a small but significant decrease in median arterial pH and standard base excess, which remained within normal limits, but lower than with Accusol® (p = 0.018 and p = 0.046, respectively). No significant differences were observed in clinical outcomes.
Conclusions: In paracetamol-induced ALF patients, Phoxilium® was associated with reduced incidence of severe hypophosphatemia, hypophosphatemia burden, and need of phosphate supplementation. Larger studies are needed to further assess its impact on ALF patient outcomes.
DOI: 10.6084/m9.figshare.30170959.v1
title: Supplementary Material for: Phoxilium® as a Phosphate-Sparing Solution for Continuous Renal Replacement Therapy in Paracetamol-Induced Acute Liver Failure

description: Background: Hypophosphatemia is common in Acute Liver Failure (ALF) and may worsen during continuous renal replacement therapy (CRRT) with phosphate-free fluids. We aimed to evaluate the safety and efficacy of Phoxilium®, a phosphate-containing CRRT fluid.
Methods: We conducted a retrospective single-centre cohort study of paracetamol-induced ALF patients treated with CRRT between as our ICU transitioned from Accusol® to Phoxilium®. We obtained data on demographics, biochemistry, and outcomes. We compared biochemical variables every 6 hours up to 48 hours post-CRRT initiation and then every 12 hours until 168 hours. The primary outcome was the occurrence of severe hypophosphatemia (&lt; 0.32 mmol/L).
Results: In 38 ALF patients (Phoxilium®=14 and Accusol®=24). Phoxilium® was associated with elimination of severe hypophosphatemia (0% vs. 38%; p=0.014), a reduction in its median burden (proportion of phosphate readings &lt; 0.81 mmol/L: 13% [IQR; 2–33%] vs. 44% [29–51%]; p=0.001), and significantly lower phosphate supplementation requirements (median, 45 mmol [20–70 mmol] vs. 100 mmol [60–210 mmol]; p=0.008). Phoxilium® patients experienced a small but significant decrease in median arterial pH and standard base excess, which remained within normal limits, but lower than with Accusol® (p = 0.018 and p = 0.046, respectively). No significant differences were observed in clinical outcomes.
Conclusions: In paracetamol-induced ALF patients, Phoxilium® was associated with reduced incidence of severe hypophosphatemia, hypophosphatemia burden, and need of phosphate supplementation. Larger studies are needed to further assess its impact on ALF patient outcomes.
DOI: 10.6084/m9.figshare.30170962
title: Supplementary Material for: Disease complexity and nodule-specific responses to atezolizumab plus bevacizumab in advanced hepatocellular carcinoma

description: Background: Advanced hepatocellular carcinoma (HCC) presents a range of presentations and responses to immunotherapy. We sought to determine the effects of Atez/Bev in patients with advanced HCC and various prognostic factors.
Methods: We analyzed 183 patients with advanced HCC who received Atez/Bev and targeted the response patterns of 517 intrahepatic tumors and 88 extrahepatic tumors, organized by poor prognostic indicators: extrahepatic metastasis (EHM), microvascular invasion (MVI) and large intrahepatic tumors (≥5 cm).
Results: The median progression-free survival (PFS) and overall survival (OS) were recorded at 8.0 months and 22.6 months, respectively, with an objective response rate of 19.7%. Response patterns differed significantly for large intrahepatic tumors (≥5 cm): these tumors progressed more slowly than smaller tumors, accompanied by a similar incidence of new lesions and target lesion progression. The correlation between PFS and OS varied notably between patients with large tumors and those without, with correlation coefficients of 0.662 (95% CI 0.559–0.764) and 0.475 (95% CI 0.326–0.624), respectively. Intrahepatic lesions displayed homogenous responses (correlation coefficient = 0.682), while the correlation between intrahepatic and extrahepatic responses was weaker (correlation coefficient = 0.474). Tumors with MVI varied their response patterns according to their associated vascular invasion, although MVI did not influence survival. EHM affected PFS and OS, while tumor size only influenced OS.
Conclusions: Large intrahepatic tumors treated with Atez/Bev demonstrate prolonged stability, incomplete responses, and worse survival. The differing correlations between PFS and OS based on tumor size have significant implications for the design of clinical trials. This may indicate a potential advantage in incorporating locoregional interventions for treating large tumors in HCC strategies.
DOI: 10.6084/m9.figshare.30170962.v1
title: Supplementary Material for: Disease complexity and nodule-specific responses to atezolizumab plus bevacizumab in advanced hepatocellular carcinoma

description: Background: Advanced hepatocellular carcinoma (HCC) presents a range of presentations and responses to immunotherapy. We sought to determine the effects of Atez/Bev in patients with advanced HCC and various prognostic factors.
Methods: We analyzed 183 patients with advanced HCC who received Atez/Bev and targeted the response patterns of 517 intrahepatic tumors and 88 extrahepatic tumors, organized by poor prognostic indicators: extrahepatic metastasis (EHM), microvascular invasion (MVI) and large intrahepatic tumors (≥5 cm).
Results: The median progression-free survival (PFS) and overall survival (OS) were recorded at 8.0 months and 22.6 months, respectively, with an objective response rate of 19.7%. Response patterns differed significantly for large intrahepatic tumors (≥5 cm): these tumors progressed more slowly than smaller tumors, accompanied by a similar incidence of new lesions and target lesion progression. The correlation between PFS and OS varied notably between patients with large tumors and those without, with correlation coefficients of 0.662 (95% CI 0.559–0.764) and 0.475 (95% CI 0.326–0.624), respectively. Intrahepatic lesions displayed homogenous responses (correlation coefficient = 0.682), while the correlation between intrahepatic and extrahepatic responses was weaker (correlation coefficient = 0.474). Tumors with MVI varied their response patterns according to their associated vascular invasion, although MVI did not influence survival. EHM affected PFS and OS, while tumor size only influenced OS.
Conclusions: Large intrahepatic tumors treated with Atez/Bev demonstrate prolonged stability, incomplete responses, and worse survival. The differing correlations between PFS and OS based on tumor size have significant implications for the design of clinical trials. This may indicate a potential advantage in incorporating locoregional interventions for treating large tumors in HCC strategies.
DOI: 10.6084/m9.figshare.30170965
title: Supplementary Material for: Municipal oral healthcare coverage and dental caries among Brazilian children

description: Introduction: Universal coverage for oral healthcare is expected to improve population oral health. However, empirical evidence to substantiate this expectation is scarce and inconsistent. This study investigated the association between municipal oral healthcare coverage and dental caries among 5-year-old children. Methods: This study pooled together individual-level data from 7185 five-year-old children who participated in the National Oral Health Survey - SB Brasil 2023 and monthly data on municipal oral healthcare coverage from January 2019 to December 2023. Dental caries was determined at cavity level in clinical examinations and summarised using the numbers of decayed teeth (dt), missing and filled teeth (mft) and decayed, missing and filled teeth (dmft). Group-based trajectory modelling was used to identify four distinct classes of municipal oral healthcare coverage: always-low, medium-low, medium-high and always-high. Multilevel negative binomial regression models, with children nested within municipalities, were fitted to test the association between municipal oral healthcare coverage and each caries measure, adjusting for demographic factors, socioeconomic conditions and oral healthcare-seeking behaviour. Results: The variance partition coefficient of the empty model (no predictors) indicated that 4.1%, 3.1% and 4.4% of the variance in the dmft, dt and mft scores was attributable to differences between municipalities. Greater municipal oral healthcare coverage was not associated with the dmft and dt scores after adjusting for covariates. In contrast, municipal oral healthcare coverage was associated with the mft score after adjustments. Children in municipalities with medium-low (1.09, 95%CI: 0.72-1.66), medium-high (1.45, 95% CI: 0.93-2.26) and always-high coverage (1.50, 95%CI: 0.88, 2.56) had on average higher mft scores compared to those in municipalities with always-low coverage (p-value for trend=0.047). Conclusion: This study shows that greater oral healthcare coverage was positively associated with more caries treatment experience but not with current untreated disease.
DOI: 10.6084/m9.figshare.30170965.v1
title: Supplementary Material for: Municipal oral healthcare coverage and dental caries among Brazilian children

description: Introduction: Universal coverage for oral healthcare is expected to improve population oral health. However, empirical evidence to substantiate this expectation is scarce and inconsistent. This study investigated the association between municipal oral healthcare coverage and dental caries among 5-year-old children. Methods: This study pooled together individual-level data from 7185 five-year-old children who participated in the National Oral Health Survey - SB Brasil 2023 and monthly data on municipal oral healthcare coverage from January 2019 to December 2023. Dental caries was determined at cavity level in clinical examinations and summarised using the numbers of decayed teeth (dt), missing and filled teeth (mft) and decayed, missing and filled teeth (dmft). Group-based trajectory modelling was used to identify four distinct classes of municipal oral healthcare coverage: always-low, medium-low, medium-high and always-high. Multilevel negative binomial regression models, with children nested within municipalities, were fitted to test the association between municipal oral healthcare coverage and each caries measure, adjusting for demographic factors, socioeconomic conditions and oral healthcare-seeking behaviour. Results: The variance partition coefficient of the empty model (no predictors) indicated that 4.1%, 3.1% and 4.4% of the variance in the dmft, dt and mft scores was attributable to differences between municipalities. Greater municipal oral healthcare coverage was not associated with the dmft and dt scores after adjusting for covariates. In contrast, municipal oral healthcare coverage was associated with the mft score after adjustments. Children in municipalities with medium-low (1.09, 95%CI: 0.72-1.66), medium-high (1.45, 95% CI: 0.93-2.26) and always-high coverage (1.50, 95%CI: 0.88, 2.56) had on average higher mft scores compared to those in municipalities with always-low coverage (p-value for trend=0.047). Conclusion: This study shows that greater oral healthcare coverage was positively associated with more caries treatment experience but not with current untreated disease.
DOI: 10.15468/dl.f7n8xx
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Physella acuta",
 "Country is Belarus",
 "HasCoordinate is true"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0021233-250914085247600/datasets/export for details.
DOI: 10.15468/dl.gqy2qm
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Physella acuta",
 "Country is Iceland",
 "HasCoordinate is true"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0021234-250914085247600/datasets/export for details.
DOI: 10.15468/dl.4p6jnu
title: Occurrence Download

description: A dataset containing 1 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Physella acuta",
 "Country is Ireland",
 "HasCoordinate is true"
 ]
}

 The dataset includes 1 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0021235-250914085247600/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.jbeg7q
title: Occurrence Download

description: A dataset containing 1635 species occurrences available in GBIF matching the query:
{
 "and" : [
 {
 "and" : [
 "HasGeospatialIssue is false",
 "HasCoordinate is true",
 "OccurrenceStatus is Present",
 {
 "not" : {
 "BasisOfRecord" : [
 "is one of (Fossil, Living Specimen)"
 ]
 }
 }
 ]
 },
 "TaxonKey is one of (Pennisetum)"
 ]
}

 The dataset includes 1635 records from 162 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0021236-250914085247600/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.6084/m9.figshare.27719451
title: <b>Multi-resolution dataset </b><b>of electricity consumption</b><b> in </b><b>Chinese cities</b>

description: Timely and spatially refined electricity consumption data are essential for supporting urban energy transition, electricity demand response, and supply-demand balancing strategies. However, publicly accessible datasets with high temporal resolution and city-level granularity remain scarce, particularly in developing countries such as China. In this study, we generate electricity consumption estimate for 296 Chinese cities in 2022 at both daily and monthly resolutions. In addition, this study presents a top-down framework for estimating city-level daily and monthly electricity consumption by integrating open-access multi-source data, including nighttime light imagery and high-resolution meteorological variables. The validation results demonstrate a strong alignment between the estimated multi-resolution values and officially reported annual statistics. This dataset addresses critical data gaps in urban-scale electricity studies by providing a publicly accessible, lower-cost, and scalable proxy for capturing electricity consumption dynamics at both daily and monthly scales. It is particularly valuable for academic research, exploratory analysis, and understanding spatiotemporal patterns of urban electricity consumption.
DOI: 10.6084/m9.figshare.27719451.v6
title: <b>Multi-resolution electricity consumption data of Chinese cities estimated using open data</b>

description: Timely and spatially refined electricity consumption data are essential for supporting urban energy transition, electricity demand response, and supply-demand balancing strategies. However, publicly accessible datasets with high temporal resolution and city-level granularity remain scarce, particularly in developing countries such as China. In this study, we generate electricity consumption estimate for 296 Chinese cities in 2022 at both daily and monthly resolutions. In addition, this study presents a top-down framework for estimating city-level daily and monthly electricity consumption by integrating open-access multi-source data, including nighttime light imagery and high-resolution meteorological variables. The validation results demonstrate a strong alignment between the estimated multi resolutions values and officially reported annual statistics. This dataset addresses critical data gaps in urban-scale electricity studies by providing a publicly accessible, lower-cost, and scalable proxy for capturing electricity consumption dynamics at both daily and monthly scales. It is particularly valuable for academic research, exploratory analysis, and understanding spatiotemporal patterns of urban electricity consumption.
DOI: 10.6084/m9.figshare.27719451.v7
title: <b>Multi-resolution dataset </b><b>of electricity consumption</b><b> in </b><b>Chinese cities</b>

description: Timely and spatially refined electricity consumption data are essential for supporting urban energy transition, electricity demand response, and supply-demand balancing strategies. However, publicly accessible datasets with high temporal resolution and city-level granularity remain scarce, particularly in developing countries such as China. In this study, we generate electricity consumption estimate for 296 Chinese cities in 2022 at both daily and monthly resolutions. In addition, this study presents a top-down framework for estimating city-level daily and monthly electricity consumption by integrating open-access multi-source data, including nighttime light imagery and high-resolution meteorological variables. The validation results demonstrate a strong alignment between the estimated multi-resolution values and officially reported annual statistics. This dataset addresses critical data gaps in urban-scale electricity studies by providing a publicly accessible, lower-cost, and scalable proxy for capturing electricity consumption dynamics at both daily and monthly scales. It is particularly valuable for academic research, exploratory analysis, and understanding spatiotemporal patterns of urban electricity consumption.
DOI: 10.15468/dl.53j6k8
title: Occurrence Download

description: A dataset containing 21 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Physella acuta",
 "Country is Israel",
 "HasCoordinate is true"
 ]
}

 The dataset includes 21 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0021237-250914085247600/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.gtnqvc
title: Occurrence Download

description: A dataset containing 390 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Physella acuta",
 "Country is Japan",
 "HasCoordinate is true"
 ]
}

 The dataset includes 390 records from 17 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0021238-250914085247600/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.2t4sdr
title: Occurrence Download

description: A dataset containing 2 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Physella acuta",
 "Country is Latvia",
 "HasCoordinate is true"
 ]
}

 The dataset includes 2 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0021239-250914085247600/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.21227/ew3q-g883
title: "Plastic Surgery Orland Park Services at a Leading Plastic Surgery Center"

description: "Discover CiPlastic Surgery, the best plastic surgery clinic Orland Park. Trusted specialists at our plastic surgery center Orland Park deliver safe, natural results."
DOI: 10.15468/dl.a5dsmy
title: Occurrence Download

description: A dataset containing 16624 species occurrences available in GBIF matching the query:
{
 "and" : [
 {
 "and" : [
 "HasGeospatialIssue is false",
 "HasCoordinate is true",
 "OccurrenceStatus is Present",
 {
 "not" : {
 "BasisOfRecord" : [
 "is one of (Fossil, Living Specimen)"
 ]
 }
 }
 ]
 },
 "TaxonKey is one of (Phalaris canariensis)"
 ]
}

 The dataset includes 16624 records from 534 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0021240-250914085247600/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.6084/m9.figshare.30170953.v1
title: Selected Paper.docx

description: Selected Paper for systematic literature review regarding the design of syntax error message
DOI: 10.6084/m9.figshare.30170953
title: Selected Paper.docx

description: Selected Paper for systematic literature review regarding the design of syntax error message
DOI: 10.6084/m9.figshare.30170983.v1
title: Azoreductases of <i>Pseudomonas</i> sp. PNPG3: a bioinformatics and molecular simulation study for azo dye detoxification

description: Synthetic dyes represent a significant environmental concern due to their persistence and toxicity. These compounds are extensively used across various industries, especially textiles, and are engineered to resist degradation, making them recalcitrant in natural ecosystems. This study focused on azoreductase (Azo) enzymes as potential bioremediation agents capable of degrading diverse azo dyes. Genome analysis of <i>Pseudomonas</i> sp. strain PNPG3 identified the presence of two distinct Azo genes, which were subsequently subjected to structural modelling. The models exhibited notably high aliphatic index values which are indicative of considerable thermostability. Structural validation of both models were performed using the ERRAT, PROCHECK, and QMEAN4 tools, confirming their reliability. Among the azo dyes evaluated, solvent black 3 exhibited the highest binding affinity, with a binding energy of −10.1 kcal/mol. It formed multiple h bonds and van der Waals interactions within the active sites of Azo-1. Congo red showed a maximum binding energy of −9.4 kcal/mol with Azo-2 from strain PNPG3, forming three h bonds within its active site. The Azo2–solvent black 3 complex exhibited the highest structural stability, as indicated by consistently low RMSD values averaging approximately 0.6 nm. Additionally, the complex maintained a low and uniform RMSF profile ranging from ∼0.2 to 0.34 nm, alongside the formation of multiple h bonds and a notable reduction in SASA, further suggested a more compact conformation with limited solvent exposure. PCA analysis further confirmed this stability. Overall, the study highlights the robust azo dye-degrading potential of strain PNPG3, emphasizing its promise for large-scale dye remediation.