cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.4964537.v1
title: Transabdominal collection of amniotic fluid “sludge” and identification of <i>Candida albicans</i> intra-amniotic infection

description: A G3P2 patient who conceived while using an intrauterine contraceptive device (IUD) presented at 20 weeks of gestation with mild irregular uterine contractions and vaginal bleeding. Sonographic examination at admission showed the presence of dense amniotic fluid “sludge” and a long sonographic uterine cervix (42 mm). To assess the microbiologic significance of amniotic fluid “sludge”, we performed a transabdominal amniocentesis. The procedure was performed under real-time ultrasound, and fluid resembling pus at gross examination was noted. Rapid amniotic fluid analysis showed the presence of a high white blood cell count and structures resembling hyphae. Amniotic fluid cultures were positive for <i>Candida albicans</i>. Treatment was begun with broad-spectrum antibiotics, including Fluconazole, upon the visualization of pus in the “sludge” material because of the presence of hyphae in the Gram stain. Despite treatment, the patient went into spontaneous preterm labor and delivered five days after admission. Placental examination revealed acute fungal histologic chorioamnionitis and funisitis. This represents the first report of transabdominal collection and analysis of amniotic fluid “sludge” and the microbiologic detection of <i>Candida albicans</i> in this material. This report provides evidence that transabdominal retrieval of “sludge” is possible and may be of significant value for patient management and selection of antimicrobial agents.
DOI: 10.6084/m9.figshare.4964996.v1
title: Remaining useful life prediction for lithium-ion batteries using a quantum particle swarm optimization-based particle filter

description: A novel RUL prediction approach for lithium-ion batteries using quantum particle swarm optimization (QPSO)-based particle filter (PF) is proposed. Compared to particle swarm optimization (PSO)-based PF, QPSO-based PF is proved to have a better performance in global searching and has fewer parameters to control, which makes QPSO-PF easier for applications. Moreover, fewer particles are required by QPSO-PF to accurately track the battery's health status, leading to a reduction of computation complexity. RUL prediction results using real data provided by NASA and compared with benchmark approaches demonstrates the superiority of the proposed approach.
DOI: 10.6084/m9.figshare.4964996
title: Remaining useful life prediction for lithium-ion batteries using a quantum particle swarm optimization-based particle filter

description: A novel RUL prediction approach for lithium-ion batteries using quantum particle swarm optimization (QPSO)-based particle filter (PF) is proposed. Compared to particle swarm optimization (PSO)-based PF, QPSO-based PF is proved to have a better performance in global searching and has fewer parameters to control, which makes QPSO-PF easier for applications. Moreover, fewer particles are required by QPSO-PF to accurately track the battery's health status, leading to a reduction of computation complexity. RUL prediction results using real data provided by NASA and compared with benchmark approaches demonstrates the superiority of the proposed approach.
DOI: 10.6084/m9.figshare.4970477
title: Anti-neuroinflammatory diterpenoids from the endangered conifer <i><i>Podocarpus imbricatus</i></i>

description: Ten diterpenoids including three new abietanes (<b>1</b>–<b>3</b>) were isolated from the twigs and needles of <i>Podocarpus imbricatus</i>, an endangered conifer growing in a Cantonese garden. The new structures were established by means of spectroscopic methods. Among the isolates, 3<i>β</i>-hydroxy-abieta-8,11,13-trien-7-one (<b>5</b>), decandrin G (<b>6</b>), and 7,15-pimaradien-18-oic acid (<b>8</b>) showed significant anti-neuroinflammatory activities by inhibiting the overproduction of nitric oxide (NO) in lipopolysaccharide (LPS)-stimulated murine BV-2 microglial cells, with IC<sub>50</sub> values of 3.7, 11.1, and 4.5 μM, respectively.
DOI: 10.6084/m9.figshare.4970477.v1
title: Anti-neuroinflammatory diterpenoids from the endangered conifer <i><i>Podocarpus imbricatus</i></i>

description: Ten diterpenoids including three new abietanes (<b>1</b>–<b>3</b>) were isolated from the twigs and needles of <i>Podocarpus imbricatus</i>, an endangered conifer growing in a Cantonese garden. The new structures were established by means of spectroscopic methods. Among the isolates, 3<i>β</i>-hydroxy-abieta-8,11,13-trien-7-one (<b>5</b>), decandrin G (<b>6</b>), and 7,15-pimaradien-18-oic acid (<b>8</b>) showed significant anti-neuroinflammatory activities by inhibiting the overproduction of nitric oxide (NO) in lipopolysaccharide (LPS)-stimulated murine BV-2 microglial cells, with IC<sub>50</sub> values of 3.7, 11.1, and 4.5 μM, respectively.
DOI: 10.6084/m9.figshare.4975559
title: primary data

description: Primary data of our manuscript entitled "Role of biochar in biodegradation of nonylphenol in sediment：microbial stimulation versus adsorptive
inhibition "
DOI: 10.6084/m9.figshare.4975559.v1
title: primary data

description: Primary data of our manuscript entitled "Role of biochar in biodegradation of nonylphenol in sediment：microbial stimulation versus adsorptive
inhibition "
DOI: 10.6084/m9.figshare.4980791
title: Effect of transcranial direct current stimulation on swallowing apraxia and cortical excitability in stroke patients

description: <b>Background:</b> Swallowing apraxia is characterized by impaired volitional swallowing but relatively preserved reflexive swallowing. Few studies are available on the effectiveness of behavioral therapy and management of the condition. <b>Objective:</b> This study aimed to investigate the effect of transcranial direct current stimulation (tDCS) on swallowing apraxia and cortical activation in stroke patients. <b>Methods:</b> The study included three inpatients (age 48–70 years; 1 male, 2 females; duration of stroke, 35–55 d) with post-stroke swallowing apraxia and six age-matched healthy subjects (age 45–65 years; 3 males, 3 females). Treatments were divided into two phases: Phase A and Phase B. During Phase A, the inpatients received three weeks of sham tDCS and conventional treatments. During Phase B, these patients received three weeks of anodal tDCS over the bilateral primary sensorimotor cortex (S<sub>1</sub>M<sub>1</sub>) of swallowing and conventional treatments. Swallowing apraxia assessments were measured in three inpatients before Phase A, before Phase B, and after Phase B. The electroencephalography (EEG) nonlinear index of approximate entropy (ApEn) was calculated for three patients and six healthy subjects. <b>Results:</b> After tDCS, scores of swallowing apraxia assessments increased, and ApEn indices increased in both stimulated and non-stimulated areas. <b>Conclusions:</b> Anodal tDCS might provide a useful means for recovering swallowing apraxia, and the recovery could be related to increased excitability of the swallowing cortex. Further investigations should explore the relationship between lesion size and/or lesion site and the prognosis of swallowing apraxia. <b>Clinical trial registry:</b>http://www.chictr.org Registration Number: ChiCTR-TRC-14004955
DOI: 10.6084/m9.figshare.4980791.v1
title: Effect of transcranial direct current stimulation on swallowing apraxia and cortical excitability in stroke patients

description: <b>Background:</b> Swallowing apraxia is characterized by impaired volitional swallowing but relatively preserved reflexive swallowing. Few studies are available on the effectiveness of behavioral therapy and management of the condition. <b>Objective:</b> This study aimed to investigate the effect of transcranial direct current stimulation (tDCS) on swallowing apraxia and cortical activation in stroke patients. <b>Methods:</b> The study included three inpatients (age 48–70 years; 1 male, 2 females; duration of stroke, 35–55 d) with post-stroke swallowing apraxia and six age-matched healthy subjects (age 45–65 years; 3 males, 3 females). Treatments were divided into two phases: Phase A and Phase B. During Phase A, the inpatients received three weeks of sham tDCS and conventional treatments. During Phase B, these patients received three weeks of anodal tDCS over the bilateral primary sensorimotor cortex (S<sub>1</sub>M<sub>1</sub>) of swallowing and conventional treatments. Swallowing apraxia assessments were measured in three inpatients before Phase A, before Phase B, and after Phase B. The electroencephalography (EEG) nonlinear index of approximate entropy (ApEn) was calculated for three patients and six healthy subjects. <b>Results:</b> After tDCS, scores of swallowing apraxia assessments increased, and ApEn indices increased in both stimulated and non-stimulated areas. <b>Conclusions:</b> Anodal tDCS might provide a useful means for recovering swallowing apraxia, and the recovery could be related to increased excitability of the swallowing cortex. Further investigations should explore the relationship between lesion size and/or lesion site and the prognosis of swallowing apraxia. <b>Clinical trial registry:</b>http://www.chictr.org Registration Number: ChiCTR-TRC-14004955
DOI: 10.6084/m9.figshare.4982708
title: Petrogenesis and tectonic implications of early Devonian mafic dike–granite association in the northern West Junggar, NW China

description: Mafic dike–granite associations are common in extensional tectonic settings and important and pivotal in reconstructing crust–mantle geodynamic processes. We report results of zircon U–Pb and hornblende <sup>40</sup>Ar-<sup>39</sup>Ar ages and major-element and trace-element data for mafic dike–granite association from the northern West Junggar, in order to constrain their ages, petrogenesis, and geodynamic process. The mafic dike–granite association was emplaced in the early Devonian. The Xiemisitai monzogranites have high SiO<sub>2</sub> contents and low MgO, Cr, and Ni concentrations, suggesting that they were mainly derived from crustal sources and were probably generated by partial melt of the juvenile mid-lower crust. The mafic dikes have low Mg<sup>#</sup> and Cr and Ni abundances, suggesting that they have experienced significant fractional crystallization. The Xiemisitai mafic dikes contain hornblende and biotite and display negative Nb–Ta–Ti anomalies, enrichment of LREEs and LILEs, and depletion of HREEs and HFSEs, consistent with an origin from a lithospheric mantle metasomatized by subducted slab-derived fluids. In addition, the Xiemisitai mafic dikes are plotted within melting trends with little to no garnet (Cpx: Grt = 6:1) in their source. The La/Yb <i>versus</i> Tb/Yb plot also indicates the presence of less than 1% residual garnet in the source region for the Xiemisitai mafic dikes. Therefore, it can be inferred that the Xiemisitai mafic dikes were generated at a correspondingly shallow depth, mostly within the spinel stability field. The Xiemisitai mafic dikes were most probably generated by the partial melting of the metasomatized lithospheric mantle at relatively shallow depths (&lt;80 km). The Xiemisitai mafic dike–granite association could have been triggered by asthenospheric upwelling as a result of the rollback of the subducted Irtysh–Zaysan oceanic lithosphere.
DOI: 10.6084/m9.figshare.4982708.v1
title: Petrogenesis and tectonic implications of early Devonian mafic dike–granite association in the northern West Junggar, NW China

description: Mafic dike–granite associations are common in extensional tectonic settings and important and pivotal in reconstructing crust–mantle geodynamic processes. We report results of zircon U–Pb and hornblende <sup>40</sup>Ar-<sup>39</sup>Ar ages and major-element and trace-element data for mafic dike–granite association from the northern West Junggar, in order to constrain their ages, petrogenesis, and geodynamic process. The mafic dike–granite association was emplaced in the early Devonian. The Xiemisitai monzogranites have high SiO<sub>2</sub> contents and low MgO, Cr, and Ni concentrations, suggesting that they were mainly derived from crustal sources and were probably generated by partial melt of the juvenile mid-lower crust. The mafic dikes have low Mg<sup>#</sup> and Cr and Ni abundances, suggesting that they have experienced significant fractional crystallization. The Xiemisitai mafic dikes contain hornblende and biotite and display negative Nb–Ta–Ti anomalies, enrichment of LREEs and LILEs, and depletion of HREEs and HFSEs, consistent with an origin from a lithospheric mantle metasomatized by subducted slab-derived fluids. In addition, the Xiemisitai mafic dikes are plotted within melting trends with little to no garnet (Cpx: Grt = 6:1) in their source. The La/Yb <i>versus</i> Tb/Yb plot also indicates the presence of less than 1% residual garnet in the source region for the Xiemisitai mafic dikes. Therefore, it can be inferred that the Xiemisitai mafic dikes were generated at a correspondingly shallow depth, mostly within the spinel stability field. The Xiemisitai mafic dikes were most probably generated by the partial melting of the metasomatized lithospheric mantle at relatively shallow depths (&lt;80 km). The Xiemisitai mafic dike–granite association could have been triggered by asthenospheric upwelling as a result of the rollback of the subducted Irtysh–Zaysan oceanic lithosphere.
DOI: 10.6084/m9.figshare.4985075
title: Two Novel SNPs of <i>PPARγ</i> Significantly Affect Weaning Growth Traits of Nanyang Cattle

description: Peroxisome-proliferator-activated receptor gamma (<i>PPARγ</i>) is a key transcription factor that controls adipocyte differentiation and energy in mammals. Therefore, <i>PPARγ</i> is a potential factor influencing animal growth traits. This study primarily evaluates <i>PPARγ</i> as candidate gene for growth traits of cattle and identifies potential molecular marker for cattle breeding. Per previous studies, <i>PPARγ</i> mRNA was mainly expressed at extremely high levels in adipose tissues as shown by quantitative real-time polymerase chain reaction analysis. Three novel SNPs of the bovine <i>PPARγ</i> gene were identified in 514 individuals from six Chinese cattle breeds: SNP1 (AC_000179.1 g.57386668 C &gt; G) in intron 2 and SNP2 (AC_000179.1 g.57431964 C &gt; T) and SNP3 (AC_000179.1 g.57431994 T &gt; C) in exon 7. The present study also investigated genetic characteristics of these SNP loci in six populations. Association analysis showed that SNP1 and SNP3 loci significantly affect weaning growth traits, especially body weight of Nanyang cattle. These results revealed that SNP1 and SNP3 are potential molecular markers for cattle breeding.
DOI: 10.6084/m9.figshare.4985075.v1
title: Two Novel SNPs of <i>PPARγ</i> Significantly Affect Weaning Growth Traits of Nanyang Cattle

description: Peroxisome-proliferator-activated receptor gamma (<i>PPARγ</i>) is a key transcription factor that controls adipocyte differentiation and energy in mammals. Therefore, <i>PPARγ</i> is a potential factor influencing animal growth traits. This study primarily evaluates <i>PPARγ</i> as candidate gene for growth traits of cattle and identifies potential molecular marker for cattle breeding. Per previous studies, <i>PPARγ</i> mRNA was mainly expressed at extremely high levels in adipose tissues as shown by quantitative real-time polymerase chain reaction analysis. Three novel SNPs of the bovine <i>PPARγ</i> gene were identified in 514 individuals from six Chinese cattle breeds: SNP1 (AC_000179.1 g.57386668 C &gt; G) in intron 2 and SNP2 (AC_000179.1 g.57431964 C &gt; T) and SNP3 (AC_000179.1 g.57431994 T &gt; C) in exon 7. The present study also investigated genetic characteristics of these SNP loci in six populations. Association analysis showed that SNP1 and SNP3 loci significantly affect weaning growth traits, especially body weight of Nanyang cattle. These results revealed that SNP1 and SNP3 are potential molecular markers for cattle breeding.
DOI: 10.6084/m9.figshare.4985189
title: Phylogeny and comparative genomic analysis of Pteriomorphia (Mollusca: Bivalvia) based on complete mitochondrial genomes

description: The subclass Pteriomorphia is a morphologically diverse and economically important group of Mollusca. We retrieved 42 mitochondrial genomes (mtGenomes) of Pteriomorphia and concatenated protein-coding genes, rRNAs and tRNAs to assess phylogenetic relationships and divergence times among the families with maximum likelihood (ML) and Bayesian inference (BI) analyses. Both ML and BI analyses strongly support the same topology except for the position of <i>Atrina pectinata</i>. Our study confirms the monophyly of the families Arcidae, Mytilidae, Pteriidae, Ostreidae and Pectinidae. Within Pteriomorphia, we recovered two clusters, one comprising Mytilidae, Arcidae and Pectinidae, the other consisting of Ostreidae, Pteriidae and Pinnidae, but we did not confirm a basal position for any family. The phylogenetic trees suggest that Ostreidae, Pteriidae and Pinnidae should be grouped as the order Ostreoida. Divergence times of major families are estimated as follows: Arcidae, 315.9 Ma; Pectinidae, 384.4 Ma; Ostreidae, 240.8 Ma; Mytilidae, 390.8 Ma. Comparative analysis indicates a low-level codon usage bias (with an average of 50.29) in mtGenomes of Pteriomorphia. In Mytilidae and Ostreidae, the codon usage bias was under mutation pressure rather than selection. Contrastingly, mutation is not the main factor in defining the codon usage in Pectinidae and Pteriidae. Among Ostreidae, Pectinidae and Mytilidae, Ka/Ks ratios range from 0.00 to 1.22 and most values (89.11%) are less than 0.20, indicating that most genes are under strong negative or purifying selection. The protein-coding gene orders show dramatically different patterns in Pteriomorphia. There is no gene block even consisting of two genes that is shared by five families.
DOI: 10.6084/m9.figshare.4985189.v1
title: Phylogeny and comparative genomic analysis of Pteriomorphia (Mollusca: Bivalvia) based on complete mitochondrial genomes

description: The subclass Pteriomorphia is a morphologically diverse and economically important group of Mollusca. We retrieved 42 mitochondrial genomes (mtGenomes) of Pteriomorphia and concatenated protein-coding genes, rRNAs and tRNAs to assess phylogenetic relationships and divergence times among the families with maximum likelihood (ML) and Bayesian inference (BI) analyses. Both ML and BI analyses strongly support the same topology except for the position of <i>Atrina pectinata</i>. Our study confirms the monophyly of the families Arcidae, Mytilidae, Pteriidae, Ostreidae and Pectinidae. Within Pteriomorphia, we recovered two clusters, one comprising Mytilidae, Arcidae and Pectinidae, the other consisting of Ostreidae, Pteriidae and Pinnidae, but we did not confirm a basal position for any family. The phylogenetic trees suggest that Ostreidae, Pteriidae and Pinnidae should be grouped as the order Ostreoida. Divergence times of major families are estimated as follows: Arcidae, 315.9 Ma; Pectinidae, 384.4 Ma; Ostreidae, 240.8 Ma; Mytilidae, 390.8 Ma. Comparative analysis indicates a low-level codon usage bias (with an average of 50.29) in mtGenomes of Pteriomorphia. In Mytilidae and Ostreidae, the codon usage bias was under mutation pressure rather than selection. Contrastingly, mutation is not the main factor in defining the codon usage in Pectinidae and Pteriidae. Among Ostreidae, Pectinidae and Mytilidae, Ka/Ks ratios range from 0.00 to 1.22 and most values (89.11%) are less than 0.20, indicating that most genes are under strong negative or purifying selection. The protein-coding gene orders show dramatically different patterns in Pteriomorphia. There is no gene block even consisting of two genes that is shared by five families.
DOI: 10.6084/m9.figshare.5002088
title: Dataset for: Zinc finger protein X-linked promotes expansion of EpCAM+ cancer stem-like cells in hepatocellular carcinoma

description: Zinc finger protein X-linked (ZFX) is frequently upregulated in multiple human malignancies and also plays a critical role in the maintenance of self-renewal in embryonic stem cells. However, the role of ZFX in liver cancer stem cells (CSCs) remains obscure. We observed that the elevated expression of both ZFX and epithelial cell adhesion molecule (EpCAM) was associated with aggressive clinicopathological features and indicated poor prognosis in patients with hepatocellular carcinoma (HCC). ZFX was commonly enriched in liver EpCAM+ CSCs. Knockdown of ZFX decreased the proportion of EpCAM+ CSCs in HCC cells and suppressed their expression of stemness-related genes, self-renewal capacity, chemoresistance, metastatic potential, and tumorigenicity. Conversely, upregulation of ZFX in CSCs rescued these inhibitory effects and enhanced stem-like properties. Mechanistically, depletion of ZFX reduced nuclear translocation and transactivation of β-catenin, thereby inhibiting the self-renewal capacity of EpCAM+ CSCs. Moreover, knockdown of β-catenin attenuated the self-renewal of EpCAM+ HCC cells stably expressing ZFX, further indicating that β-catenin is required for ZFX-mediated expansion and maintenance of EpCAM+ CSCs. Taken together, our findings indicate that ZFX activates and maintains EpCAM+ liver CSCs by promoting nuclear translocation and transactivation of β-catenin. Furthermore, combination of ZFX and EpCAM may serve as a significant indicator for prognosis of patients with HCC.
DOI: 10.6084/m9.figshare.5002088.v1
title: Dataset for: Zinc finger protein X-linked promotes expansion of EpCAM+ cancer stem-like cells in hepatocellular carcinoma

description: Zinc finger protein X-linked (ZFX) is frequently upregulated in multiple human malignancies and also plays a critical role in the maintenance of self-renewal in embryonic stem cells. However, the role of ZFX in liver cancer stem cells (CSCs) remains obscure. We observed that the elevated expression of both ZFX and epithelial cell adhesion molecule (EpCAM) was associated with aggressive clinicopathological features and indicated poor prognosis in patients with hepatocellular carcinoma (HCC). ZFX was commonly enriched in liver EpCAM+ CSCs. Knockdown of ZFX decreased the proportion of EpCAM+ CSCs in HCC cells and suppressed their expression of stemness-related genes, self-renewal capacity, chemoresistance, metastatic potential, and tumorigenicity. Conversely, upregulation of ZFX in CSCs rescued these inhibitory effects and enhanced stem-like properties. Mechanistically, depletion of ZFX reduced nuclear translocation and transactivation of β-catenin, thereby inhibiting the self-renewal capacity of EpCAM+ CSCs. Moreover, knockdown of β-catenin attenuated the self-renewal of EpCAM+ HCC cells stably expressing ZFX, further indicating that β-catenin is required for ZFX-mediated expansion and maintenance of EpCAM+ CSCs. Taken together, our findings indicate that ZFX activates and maintains EpCAM+ liver CSCs by promoting nuclear translocation and transactivation of β-catenin. Furthermore, combination of ZFX and EpCAM may serve as a significant indicator for prognosis of patients with HCC.
DOI: 10.6084/m9.figshare.5005556
title: A novel nonsense NBEAL2 gene mutation causing severe bleeding in a patient with gray platelet syndrome

description: Gray platelet syndrome (GPS) is a rare, inherited bleeding disorder characterized by the defect of platelet α-granule. Up to date, these are only four studies identifying NBEAL2 gene correlated with GPS. In the current report, we present a Chinese GPS patient who had severe bleeding tendency, abnormalities of platelet functions, and absence of platelet α-granules. Genomic DNA sequencing for the patient identified a nonsense mutation (g.27713C&gt;A) of NBEAL2 gene (g.NG__031914.1) resulting in a premature protein (p.Glu1726*). In comparison with the reported patients, we conclude that homozygotes with nonsense or deletion mutation leading to a premature stop codon exhibit more serious bleeding problem than those with missense mutations.