cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.12860060
title: Raw data PSS_GAD Psychosocial impact of lockdown.csv

description: Background: Research on the psychosocial toll of the COVID-19 pandemic is being conducted in various countries. This study aimed to examine the levels and the causal stressors for perceived stress and generalized anxiety in the Indian population related to the lockdown during the COVID-19 pandemic. Methods: A total of 300 adults were approached to participate in the online study via snowball and virtual snowball sampling. They were requested to complete electronic survey forms for assessing perceived stress and anxiety, and questions related to psychosocial stressors. Frequency and percentage was used for categorical variables. One-way ANOVA test was applied to compare responses based on gender, level of education, employment, and place of residence. A p-value of &lt;0.05 was considered statistically significant. Result: 257, out of the 300 participants who were requested, responded and completed the survey. Males constituted 58% (n=149) of the respondents. Overall, 84 % (n=217) participants had moderate to severe levels of perceived stress and 88 % (n=228) had moderate to severe levels of anxiety.<em></em> Conclusion: The psychosocial impact of the nationwide lockdown on the Indian population has been high. The vulnerable groups for stress and anxiety include females, younger age, and the unemployed. The stressors recognized include fear of contracting COVID-19, inability to execute routine exercise schedule and worry about the future.
DOI: 10.6084/m9.figshare.12860060.v1
title: Raw data PSS_GAD Psychosocial impact of lockdown.csv

description: Background: Research on the psychosocial toll of the COVID-19 pandemic is being conducted in various countries. This study aimed to examine the levels and the causal stressors for perceived stress and generalized anxiety in the Indian population related to the lockdown during the COVID-19 pandemic. Methods: A total of 300 adults were approached to participate in the online study via snowball and virtual snowball sampling. They were requested to complete electronic survey forms for assessing perceived stress and anxiety, and questions related to psychosocial stressors. Frequency and percentage was used for categorical variables. One-way ANOVA test was applied to compare responses based on gender, level of education, employment, and place of residence. A p-value of &lt;0.05 was considered statistically significant. Result: 257, out of the 300 participants who were requested, responded and completed the survey. Males constituted 58% (n=149) of the respondents. Overall, 84 % (n=217) participants had moderate to severe levels of perceived stress and 88 % (n=228) had moderate to severe levels of anxiety.<em></em> Conclusion: The psychosocial impact of the nationwide lockdown on the Indian population has been high. The vulnerable groups for stress and anxiety include females, younger age, and the unemployed. The stressors recognized include fear of contracting COVID-19, inability to execute routine exercise schedule and worry about the future.
DOI: 10.17632/fp8rjzws6j.4
title: Data for: Correlates of Stalking in Canada: A Model of Social Support and Comorbidity

description: Canadian General Survey, Cycle 23
DOI: 10.5281/zenodo.4035601
title: Data For: Where are Mars' Hypothesized Ocean Shorelines? Large Lateral and Topographic Offsets Between Different Versions of Paleoshoreline Maps.

description: Data used in the analysis of the Arabia and Deuteronilus Levels for Sholes et al. (2020) submitted to the Journal of Geophysical Research: Planets. Contains ArcGIS-ready data and CSV files for all digitized, mapped, and provided putative martian paleoshorelines analyzed in the paper.
DOI: 10.15479/at:ista:8375
title: Supplementary data for "Computational design of curved thin shells: from glass façades to programmable matter"

description: Supplementary movies showing the following sequences for spatio-temporarily programmed shells: input geometry and actuation time landscape; comparison of morphing processes from a camera recording and a simulation; final actuated shape.
DOI: 10.6084/m9.figshare.12992477.v1
title: R0229_20181025a_videos

description: Rat 0229, skilled reaching data collected in Leventhal laboratory by Alexandra Bova
DOI: 10.6084/m9.figshare.12931247
title: Complex interactions of temperature, light and tissue damage on seagrass wasting disease in Zostera marina

description: <b>Abstract</b>The temperate seagrass species eelgrass <i>Zostera marina</i> can be infected by the wasting disease pathogen <i>Labyrinthula zosterae, </i>which is believed to have killed about 90% of the seagrass in the Atlantic Ocean in the 1930s. It is not known why this opportunistic pathogen sometimes becomes virulent, but the recurrent outbreaks may be due to a weakening of the <i>Z. marina</i> plants from adverse environmental changes.This study investigated the individual and interactive effects of multiple extrinsic factors (temperature, light, and tissue damage) on the host-pathogen interaction between <i>Z. marina</i> and <i>L. zosterae</i> in a fully crossed infection experiment. The degree of infection was measured as both lesion coverage and<i> L. zosterae</i> cell concentration. We also investigated if the treatment factors affect the chemical defense of the host, measured as the inhibitory capacity of seagrass extracts in bioassays with <i>L. zosterae</i>. Finally, gene expression of a set of targeted genes was quantified in order to investigate how the treatments change <i>Z. marina</i>’s response to infection.Light had a pronounced effect on <i>L. zosterae</i> infection measured as lesion coverage, where reduced light conditions increased lesions by 35%. The response to light on <i>L. zosterae</i> cell concentration was more complex and showed significant interaction with the temperature treatment. Cell concentration was also significantly affected by physical damage, where damage surprisingly resulted in a reduced cell concentration of the pathogen. No treatment factor caused detectable decrease in the inhibitory capacity of the seagrass extracts. There were several interactive effects between <i>L. zosterae</i> infection and the treatment factors on <i>Z. marina</i> growth, and on the expression of genes associated with immune defense, phenol synthesis and primary metabolism, showing that the molecular reaction towards <i>L. zosterae</i> infection depends on prevailing environmental conditions. Our study shows that individual or interactive effects of light, temperature and tissue damage can affect multiple aspects of host-pathogen interactions in seagrass. These results highlights the complexity of marine host-pathogen systems, showing that more multi-factorial investigations are needed to gain a better understanding of disease in marine plants under different environmental conditions.
DOI: 10.6084/m9.figshare.12931247.v1
title: Complex interactions of temperature, light and tissue damage on seagrass wasting disease in Zostera marina

description: <b>Abstract</b>The temperate seagrass species eelgrass <i>Zostera marina</i> can be infected by the wasting disease pathogen <i>Labyrinthula zosterae, </i>which is believed to have killed about 90% of the seagrass in the Atlantic Ocean in the 1930s. It is not known why this opportunistic pathogen sometimes becomes virulent, but the recurrent outbreaks may be due to a weakening of the <i>Z. marina</i> plants from adverse environmental changes.This study investigated the individual and interactive effects of multiple extrinsic factors (temperature, light, and tissue damage) on the host-pathogen interaction between <i>Z. marina</i> and <i>L. zosterae</i> in a fully crossed infection experiment. The degree of infection was measured as both lesion coverage and<i> L. zosterae</i> cell concentration. We also investigated if the treatment factors affect the chemical defense of the host, measured as the inhibitory capacity of seagrass extracts in bioassays with <i>L. zosterae</i>. Finally, gene expression of a set of targeted genes was quantified in order to investigate how the treatments change <i>Z. marina</i>’s response to infection.Light had a pronounced effect on <i>L. zosterae</i> infection measured as lesion coverage, where reduced light conditions increased lesions by 35%. The response to light on <i>L. zosterae</i> cell concentration was more complex and showed significant interaction with the temperature treatment. Cell concentration was also significantly affected by physical damage, where damage surprisingly resulted in a reduced cell concentration of the pathogen. No treatment factor caused detectable decrease in the inhibitory capacity of the seagrass extracts. There were several interactive effects between <i>L. zosterae</i> infection and the treatment factors on <i>Z. marina</i> growth, and on the expression of genes associated with immune defense, phenol synthesis and primary metabolism, showing that the molecular reaction towards <i>L. zosterae</i> infection depends on prevailing environmental conditions. Our study shows that individual or interactive effects of light, temperature and tissue damage can affect multiple aspects of host-pathogen interactions in seagrass. These results highlights the complexity of marine host-pathogen systems, showing that more multi-factorial investigations are needed to gain a better understanding of disease in marine plants under different environmental conditions.
DOI: 10.6084/m9.figshare.12993536
title: hawaii volume

description: hawaii tourism volume
DOI: 10.6084/m9.figshare.12993536.v1
title: hawaii volume

description: hawaii tourism volume
DOI: 10.5517/ccdc.csd.cc22j9rp
title: CCDC 1922302: Experimental Crystal Structure Determination

description: Related Article: Yan-Long Luo, Yu-Feng Liu, Bing-Tao Guan|2020|Org.Biomol.Chem.|18|6622|doi:10.1039/D0OB01499K
DOI: 10.5517/ccdc.csd.cc24sbpz
title: CCDC 1989601: Experimental Crystal Structure Determination

description: Related Article: Chandrashekhar Rapelli, Balasubramanian Sridhar, B. V. Subba Reddy|2020|Org.Biomol.Chem.|18|6710|doi:10.1039/D0OB01384F
DOI: 10.5517/ccdc.csd.cc250r76
title: CCDC 1996717: Experimental Crystal Structure Determination

description: Related Article: Yu-Chao Wang, Zhuang Fang, KeKe Huang, Guanyinsheng Qiu, Jin-Biao Liu|2020|Mol.Catal.|495|111163|doi:10.1016/j.mcat.2020.111163
DOI: 10.5517/ccdc.csd.cc250r87
title: CCDC 1996718: Experimental Crystal Structure Determination

description: Related Article: Yu-Chao Wang, Zhuang Fang, KeKe Huang, Guanyinsheng Qiu, Jin-Biao Liu|2020|Mol.Catal.|495|111163|doi:10.1016/j.mcat.2020.111163
DOI: 10.6084/m9.figshare.12993479
title: Supplementary Material for: Characterization of Clinical Cases of Malignant PEComa via Comprehensive Genomic Profiling of DNA and RNA

description: <b><i>Purpose:</i></b> Perivascular epithelioid cell tumor (PEComa) is a rare mesenchymal soft tissue neoplasm often linked to mTOR pathway activation via TSC2 mutation. We analyzed a series of 31 consecutive metastatic PEComa (mPEComa) cases using a combined DNA/RNA hybrid capture-based comprehensive genomic profiling (CGP) assay to assess the genomic landscape of mPEComa. <b><i>Patients and Methods:</i></b> Formalin-fixed, paraffin-embedded (FFPE) blocks or slides were obtained from tumors from 31 unique patients with mPEC­oma. DNA and RNA were extracted and CGP was performed on 405 genes using a targeted next-generation sequencing (NGS) assay in a CLIA-certified lab. <b><i>Results:</i></b> All cases had locally advanced or metastatic disease, and 58% of patients were female with a median age of 50 years (range 8–76), and 17 and 14 specimens were from primary and metastatic sites, respectively. One hundred genomic alterations were identified in the cohort, with an average of 3.2 genomic alterations/case including alterations in <i>TSC2</i> 32.3% of cases (10), <i>TSC1</i> 9.6% (3), <i>TFE3</i> 16.1% (5, all fusions), and folliculin (<i>FLCN</i>) 6.4% (2), with all occurring in mutually exclusive fashion. Of <i>TSC2</i> mutant cases, 70% had biallelic inactivation of this locus, as were 100% of <i>TSC1</i> mutant cases. Two <i>TSC1/2</i> wildtype cases harbored truncating mutations in <i>FLCN</i>, both of which were under LOH. Five <i>TFE3</i> fusion cases were identified including the novel 5′ fusion partner <i>ZC3H4</i>. <b><i>Conclusions:</i></b> We describe for the first time mPEComa cases with <i>FLCN</i> mutations under LOH, further characterizing dysregulation of the mTOR pathway as a unifying theme in mPEC­oma. Cumulatively, we demonstrate the feasibility and potential utility of segregating mPEComa by <i>TSC</i>, <i>TFE3</i>, and <i>FLCN</i> status via CGP in clinical care.
DOI: 10.6084/m9.figshare.12993398
title: Supplementary Material for: Exenatide and Renal Outcomes in Patients with Type 2 Diabetes and Diabetic Kidney Disease

description: <b><i>Background:</i></b> Cardiovascular outcomes in clinical trials with type 2 diabetes mellitus (T2DM) patients have shown that glucagon-like peptide-1 receptor agonist can have a beneficial effect on the kidney. This trial aimed to assess the effects of exenatide on renal outcomes in patients with T2DM and diabetic kidney disease (DKD). <b><i>Methods:</i></b> We performed a randomized parallel study encompassing 4 general hospitals. T2DM patients with an estimated glomerular filtration rate (eGFR) ≥30 mL/min/1.73 m<sup>2</sup> and macroalbuminuria, defined as 24-h urinary albumin excretion rate (UAER) &gt;0.3 g/24 h were randomized 1:1 to receive exenatide twice daily plus insulin glargine (intervention group) or insulin lispro plus glargine (control group) for 24 weeks. The primary outcome was the UAER percentage change from the baseline after 24 weeks of intervention. The rates of hypoglycemia, adverse events (AEs), and change in eGFR during the follow-up were measured as safety outcomes. <b><i>Results:</i></b> Between March 2016 and April 2019, 92 patients were randomized and took at least 1 dose of the study drug. The mean age of the participants was 56 years. At baseline, the median UAER was 1,512.0 mg/24 h and mean eGFR was 70.4 mL/min/1.73 m<sup>2</sup>. After 24 weeks of treatment, the UAER percentage change was significantly lower in the intervention group than in the control group (<i>p</i> = 0.0255). Moreover, the body weight declined by 1.3 kg in the intervention group (the difference between the 2 groups was 2.7 kg, <i>p</i> = 0.0001). Compared to the control group, a lower frequency of hypoglycemia and more gastrointestinal AEs were observed in the intervention group. <b><i>Conclusion:</i></b> Exenatide plus insulin glargine treatment for 24 weeks resulted in a reduction of albuminuria in T2DM patients with DKD.
DOI: 10.6084/m9.figshare.12993389
title: Supplementary Material for: Real World Use and Effects of Calcimimetics in Treating Mineral and Bone Disorder in Hemodialysis Patients

description: <b><i>Background:</i></b> Calcimimetics are used to treat mineral and bone disorder by reducing parathyroid hormone (PTH), calcium (Ca), and phosphorus (Phos). The study objectives were to assess the control of PTH, Ca, and Phos over time in patients receiving cinacalcet or etelcalcetide as well as dosing and time to discontinuation for etelcalcetide. <b><i>Methods:</i></b> This was a retrospective cohort study using electronic medical records from small and independent dialysis centers. Adults ≥18 years of age were identified as cinacalcet or etelcalcetide users based on the first calcimimetic received in 2018 (index date). Patients were followed from the index date until parathyroidectomy, kidney transplant, death, or end of data (December 31, 2018). Analyses of mean PTH, Ca, and Phos, as well as target achievement of PTH, Ca, and Phos were conducted over a 9-month period. Discontinuation with etelcalcetide was measured with the Kaplan-Meier estimator. <b><i>Results:</i></b> There were 1,346 cinacalcet patients (mean age 60.5 years, 43.5% female, and 47.1% Black) and 1,255 etelcalcetide patients (mean age 63.4 years, 46.6% female, and 38.5% Black). At baseline, the proportions in target were similar for etelcalcetide versus cinacalcet: 36 versus 38% for PTH, 79 versus 80% for Ca, and 43 versus 44% for Phos. Overall, 40–47% of cinacalcet users and 48–62% of etelcalcetide users were observed to be in target for PTH over 9 months. The proportion in target for Phos ranged from 41 to 46% for cinacalcet and 46–51% for etelcalcetide. The proportion in target for Ca ranged from 74 to 78% for cinacalcet and 60–73% for etelcalcetide. Etelcalcetide 12-month discontinuation was 37.4%. <b><i>Conclusion:</i></b> Both calcimimetics were effective in keeping PTH, Ca, and Phos levels within target. Patients receiving etelcalcetide tended to have lower laboratory values for PTH, Ca, and Phos over time, while patients receiving cinacalcet tended to be more likely to be in target for Ca over time.
DOI: 10.6084/m9.figshare.12993494
title: Supplementary Material for: Inflammatory Dietary Patterns and Risk of Keratinocyte Cancers in Kidney Transplant Recipients: Prospective Cohort Study

description: <b><i>Background:</i></b> Kidney transplant recipients (KTRs) are at increased risk of cutaneous squamous (SCC) and basal cell carcinomas (BCC) due to immunosuppression and sun exposure. Skin carcinogenesis involves inflammation, and foods that promote inflammation may promote carcinogenesis. <b><i>Methods:</i></b> We prospectively examined the association between pro-inflammatory diets and SCC and BCC incidence in KTRs in Queensland, Australia. We recruited KTRs at high risk of skin cancer (aged ≥18 years and previously affected; or aged ≥40; or immunosuppressed ≥10 years) between 2012 and 2014 and followed up until June 2016. A baseline dietary questionnaire was used to calculate modified-Empirical Dietary Inflammatory Pattern (EDIP) scores to indicate dietary inflammatory capacity; higher scores indicated pro-inflammatory diets. EDIP scores were ranked into 3 groups. Outcomes were histologically confirmed SCC and BCC. Adjusted relative risks (RR<sub>adj</sub>) and 95% CIs were estimated using negative binomial regression. <b><i>Results:</i></b> Among 260 KTRs, 100 (38%) and 93 (36%) developed at least 1 new SCC and BCC, with 426 SCC and 343 BCC diagnosed in the follow-up period. The highest modified-EDIP score group (vs. lowest) were at increased risk of SCC (RR<sub>adj</sub> 1.79, 95% CI 1.01–3.16) but not BCC. Pro-inflammatory diets may increase SCC but not BCC risk among KTRs. <b><i>Conclusions:</i></b> Inflammatory diets may increase the risk of SCC in KTRs.
DOI: 10.6084/m9.figshare.12993509
title: Supplementary Material for: Thyroid Disease and Active Smoking May Be Associated with More Severe Hidradenitis Suppurativa: Data from a Prospective Cross Sectional Single-Center Study

description: <b><i>Introduction:</i></b> Hidradenitis suppurativa (HS) is an obscure disease presenting with painful, deep-seated nodules and abscess formation in body areas rich in apocrine glands. Several factors, including thyroid disease and active smoking, have been reported to be associated with HS, but it remains unclear if such associations are related to clinical HS severity. The aim of this prospective cross-sectional study is to investigate the association between active smoking and thyroid disease and HS, as well as to determine if these associations are related to HS severity. <b><i>Methods:</i></b> Eligible were all patients seen in our HS outpatient clinic between September 2018 and February 2020. Data regarding demographic characteristics, clinical disease severity, comorbidities, and treatment modalities were registered. Descriptive statistics of demographic and disease characteristics was conducted. In order to evaluate the association between the disease stage and certain variables of interest, ordered logistic regression was performed. <b><i>Results:</i></b> A total of 290 patients were included in the study. Of these, 48.9% were males, and 51.1% females. The patients had a mean age of 37.3 years. A total of 42.4% of the patients were at Hurley stage I, 43.1% at stage II, and 14.5% at stage III. According to the IHS4 score system, 30.7% of the patients had mild, 50.3% moderate, and 19.0% severe disease. The median duration of disease was 10 years. Among the patients, 56.5% were active smokers, and 55.5% patients reported that stress triggers the disease’s flares. Univariable analyses demonstrated that among the various covariates, active smoking and thyroid disease were associated with a higher stage of disease. <b><i>Conclusion:</i></b> We conclude that thyroid disease and active smoking may be associated with more severe HS.
DOI: 10.6084/m9.figshare.12993509.v1
title: Supplementary Material for: Thyroid Disease and Active Smoking May Be Associated with More Severe Hidradenitis Suppurativa: Data from a Prospective Cross Sectional Single-Center Study

description: <b><i>Introduction:</i></b> Hidradenitis suppurativa (HS) is an obscure disease presenting with painful, deep-seated nodules and abscess formation in body areas rich in apocrine glands. Several factors, including thyroid disease and active smoking, have been reported to be associated with HS, but it remains unclear if such associations are related to clinical HS severity. The aim of this prospective cross-sectional study is to investigate the association between active smoking and thyroid disease and HS, as well as to determine if these associations are related to HS severity. <b><i>Methods:</i></b> Eligible were all patients seen in our HS outpatient clinic between September 2018 and February 2020. Data regarding demographic characteristics, clinical disease severity, comorbidities, and treatment modalities were registered. Descriptive statistics of demographic and disease characteristics was conducted. In order to evaluate the association between the disease stage and certain variables of interest, ordered logistic regression was performed. <b><i>Results:</i></b> A total of 290 patients were included in the study. Of these, 48.9% were males, and 51.1% females. The patients had a mean age of 37.3 years. A total of 42.4% of the patients were at Hurley stage I, 43.1% at stage II, and 14.5% at stage III. According to the IHS4 score system, 30.7% of the patients had mild, 50.3% moderate, and 19.0% severe disease. The median duration of disease was 10 years. Among the patients, 56.5% were active smokers, and 55.5% patients reported that stress triggers the disease’s flares. Univariable analyses demonstrated that among the various covariates, active smoking and thyroid disease were associated with a higher stage of disease. <b><i>Conclusion:</i></b> We conclude that thyroid disease and active smoking may be associated with more severe HS.