cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.5281/zenodo.13893271
title: ANALYSIS OF GIRLS' HEALTH PROBLEMS IN ADOLESCENCE AND PREDICTION OF PCOS

description: The relevance of the study of reproductive health and risk assessment of polycystic ovary syndrome (PCOS) is related to the fact that this disease is a common cause of infertility, and is also a global somatic health problem, including disorders of the endocrine-metabolic status, cardiovascular diseases and has a high oncological risk. The aim of the study is to evaluate the results of clinical and anamnestic indicators that contribute to the development of PCOS in adolescent girls. The study included 182 adolescent girls from 13 to 17 years old, who were interviewed with questionnaires that reflected such health issues as the characteristics of menstrual function, metabolic disorders, genetic predisposition to diabetes mellitus and arterial hypertension. The degrees of development of the mammary glands were also assessed according to the Tanner scale and the degree of hirsutism according to the Ferriman-Gallwey scale. Thus, according to the results of the study, it is clear that half of the adolescent girls in Tashkent suffer from algomenorrhea syndrome. Our region is also prone to anemia due to the monthly loss of large amounts of blood. It should be noted that almost half of the girls have intermenstrual bleeding, which may be associated with an unsettled menstrual cycle, but this is observed in every second girl. As is known, theoretically, thelarche occurs a year earlier than menarche. Our studies have confirmed the results of previous studies. More than half of the girls assess their skin condition as unsatisfactory, noting acne, which is considered a physiological norm, but this is not satisfactory and leads to depression. Of particular note is the burden of diabetes mellitus and arterial hypertension in relatives. Most girls suffer from hirsutism. The onset of puberty is a critical moment in the development of PCOS and early intervention is, in the opinion of researchers in recent years, mandatory.

Key words: PCOS, hyperandrogenemia, acne, anovulation, insulin resistance, obesity, body mass index.
DOI: 10.5281/zenodo.13893272
title: ANALYSIS OF GIRLS' HEALTH PROBLEMS IN ADOLESCENCE AND PREDICTION OF PCOS

description: The relevance of the study of reproductive health and risk assessment of polycystic ovary syndrome (PCOS) is related to the fact that this disease is a common cause of infertility, and is also a global somatic health problem, including disorders of the endocrine-metabolic status, cardiovascular diseases and has a high oncological risk. The aim of the study is to evaluate the results of clinical and anamnestic indicators that contribute to the development of PCOS in adolescent girls. The study included 182 adolescent girls from 13 to 17 years old, who were interviewed with questionnaires that reflected such health issues as the characteristics of menstrual function, metabolic disorders, genetic predisposition to diabetes mellitus and arterial hypertension. The degrees of development of the mammary glands were also assessed according to the Tanner scale and the degree of hirsutism according to the Ferriman-Gallwey scale. Thus, according to the results of the study, it is clear that half of the adolescent girls in Tashkent suffer from algomenorrhea syndrome. Our region is also prone to anemia due to the monthly loss of large amounts of blood. It should be noted that almost half of the girls have intermenstrual bleeding, which may be associated with an unsettled menstrual cycle, but this is observed in every second girl. As is known, theoretically, thelarche occurs a year earlier than menarche. Our studies have confirmed the results of previous studies. More than half of the girls assess their skin condition as unsatisfactory, noting acne, which is considered a physiological norm, but this is not satisfactory and leads to depression. Of particular note is the burden of diabetes mellitus and arterial hypertension in relatives. Most girls suffer from hirsutism. The onset of puberty is a critical moment in the development of PCOS and early intervention is, in the opinion of researchers in recent years, mandatory.

Key words: PCOS, hyperandrogenemia, acne, anovulation, insulin resistance, obesity, body mass index.
DOI: 10.15151/esrf-es-1957740205
title: Structural Biology at EMBL Grenoble, IBS-CIBB and IAB

description: This proposal clusters crystallography and bioSAXS projects at the EMBL Grenoble, IBS-CIBB and IAB. It combines groups working on different topics with a major focus on cell signaling proteins, drug discovery, long non-coding RNAs, nucleic acid-protein complexes, and host-pathogen interactions. The proposers have long-standing experience in the use, as well as the development of beam lines for macromolecular crystallography and biological small angle X-ray scattering and have participated in successive BAG applications over the years, mostly at the ESRF but also at other synchrotrons. The BAG responsible is Andrew McCarthy (EMBL Grenoble) for this application round.
DOI: 10.15151/esrf-es-1897083537
title: SAARLAND BAG: ATOMIC MECHANISMS OF ACTION OF MEMBRANE PROTEINS AND BIOSYNTHETIC ENZYMES

description: Projects are focussed primarily within the framework of local collaborations on "Ca2+signals: Molecular
Mechanisms und Integrative Functions" at Saarland University and on natural bioactive compounds including their interactions with their target proteins with the Food Chemistry Department at Leibniz University in Hannover. These projects involve the structure determination of membrane proteins and soluble proteins.
DOI: 10.15151/esrf-es-1913414824
title: In-operando x-ray imaging on alkaline electrolyzer for improved understanding of bubble dynamics

description: Green hydrogen produced via electrolysis is predicted to be a key technology to enabling the green energy transition. For decreasing the green hydrogen cost to comparable levels to hydrogen produced by steam reforming, the electrolyzer systems must be optimised. One of the most significant energy losses during electrolyzer operation at industrial conditions is due to inefficient mass transport. 
Previous neutron radiographic measurements have indicated that bubbles are immobilized in industrial porous foam electrodes, effectively increasing the resistance and decreasing the available surface area in the system. By performing x-ray imaging we will be able to study the growth, movement, and distribution of bubbles for improved understanding on this critical topic. The electrolyzer is constructed in cooperation with the industry to obtain the most industrially relevant and accurate knowledge on bubble dynamics.
DOI: 10.15151/esrf-es-1919142330
title: SAXS/WAXS studies on morphology of alloying anodes for Na-ion batteries

description: Alloying anode materials for metal-ion batteries provide higher capacity than traditional intercalation materials, at the cost of cycle stability. Many parameters can affect their lifetime and performance in a battery, including particle size and size of the pores in the electrode. With increasing particle size, diffusion limits the progress of chemical reactions. Larger pore size can improve ion diffusion at a cost of lower energy density. Small-angle X-ray scattering (SAXS) is a tool to investigate nanostructural changes occurring in a short range, which are complementary to the atomic scale, long range information obtained with wide-angle Xray scattering (WAXS). We will study the changes in porosity and particle size for Sn, Sb and Bi anode materials during cycling in Na-ion batteries. By measuring these parameters during battery operation, we aim to get a better understanding of morphological changes during cycling, and find the optimal balance between porosity and particle size.
DOI: 10.15151/esrf-es-1919144944
title: Operando studies of cathode materials with antiperovskite structure

description: The aim of this proposal is to study a new class of cathode materials for Li-ion batteries (LIBs): disordered antiperovskites (APs). Specifically, Li2MnSeO and Li2FeSeO are of particular interest due to simplicity of preparation and abundancy of elements. Our preliminary experiments indicated that Li2MnSeO shows high working potential while Li2FeSeO provides high capacity. However, further improvements of these materials are impeded by the lack of understanding of their mechanism during electrochemical cycling in LIB. As the structure evolution upon cycling can be elucidated by the combination of ex situ and operando measurements, we expect to gain deeper insights into the de/lithiation mechanism of AP cathodes.
DOI: 10.15151/esrf-es-1883532581
title: Dynamic interaction of nanoparticles of different curvatures with cell media, proteins and pH

description: Lipid lyotropic liquid crystalline nanoparticles (LCNPs) have attracted enormous attention for biomedical applications, such as drug delivery, due to their high biocompatibility and different structures giving rise to distinct properties. For e.g., tuning the nanostructure of LCNPs results in a significant difference in the release profile of encapsulated bioactives. However, it is uncertain whether these LCNPs retain their original structure upon contact with physiological relevant media at body temperature, and the link between their internal nanostructure and cell cytotoxicity. Here we will use SAXS to unravel the real-time phase behaviour of LCNPs with different cell media, and further investigate the relationship between nanostructure, cell cytotoxicity and uptake. The results will shed light on future strategies to transform LCNPs into a viable therapeutic entity ideal for biomedical applications.
DOI: 10.15151/esrf-es-1883533888
title: Mechanics of large-format Li-ion cell with attenuation-based- and diffraction-CT

description: The inner mechanics of large-format cylindrical 4680-type Li-ion batteries are proposed to be studied non-destructively using high-resolution CT and XRD-CT supplying a pixel resolution below 1 µm to the object with radial dimensions of 46 mm. Studies will be carried out at different states of charge capable of following the anisotropic expansion of the cell in its inner and outer regions. Based on obtained CT data with sub-µm pixel resolution, the XRD-CT experiment, performed in the field-of-view manner, will allow to extract structural information of the chosen region-of-interest.
DOI: 10.6084/m9.figshare.26085745
title: Scalable production of uniform and mature organoids in a 3D geometrically-engineered permeable membrane

description: Scalable production of uniform and mature organoids in a 3D geometrically-engineered permeable membrane
DOI: 10.6084/m9.figshare.27117540
title: Holographic Multiplexing Metasurface with Twisted Diffractive Neural Network

description: phase mask of the diffractive neural network
DOI: 10.6084/m9.figshare.27117540.v1
title: Holographic Multiplexing Metasurface with Twisted Diffractive Neural Network

description: phase mask of the diffractive neural network
DOI: 10.6084/m9.figshare.25055555
title: CYP5122A1 encodes an essential sterol C4-methyl oxidase in Leishmania donovani and determines the antileishmanial activity of antifungal azoles

description: Source data for plots and tables in the manuscript.
DOI: 10.6084/m9.figshare.25055555.v1
title: CYP5122A1 encodes an essential sterol C4-methyl oxidase in Leishmania donovani and determines the antileishmanial activity of antifungal azoles

description: Source data for plots and tables in the manuscript.
DOI: 10.5281/zenodo.10909223
title: OSTEOPOROSIS IN PERIMENOPAUSAL WOMEN. WAYS OF DI-AGNOSIS, CORRECTION AND PREVENTION (LITERATURE REVIEW)

description: Остеопороз, как хроническое системное заболевание опорно-двигательной системы, снижает прочность костной системы за счёт нарушения обмена веществ и микроархитектоники костей. Это в результате нередко приводит к патологическим переломам. В докладе Международной Ассоциации остеопороза говорится, что ежегодно в мире переломы в результате остеопороза встречаются у 30-33% женщин в возрасте старше 50 лет
DOI: 10.5281/zenodo.10909224
title: OSTEOPOROSIS IN PERIMENOPAUSAL WOMEN. WAYS OF DI-AGNOSIS, CORRECTION AND PREVENTION (LITERATURE REVIEW)

description: Остеопороз, как хроническое системное заболевание опорно-двигательной системы, снижает прочность костной системы за счёт нарушения обмена веществ и микроархитектоники костей. Это в результате нередко приводит к патологическим переломам. В докладе Международной Ассоциации остеопороза говорится, что ежегодно в мире переломы в результате остеопороза встречаются у 30-33% женщин в возрасте старше 50 лет
DOI: 10.15468/dl.ggacby
title: Occurrence Download

description: A dataset listing the 20 species recorded in GBIF matching the query:
{
 "TaxonKey" : [
 "is Coffea arabica L."
 ]
}

 The dataset's 20 records were derived from 517 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0017023-241024112534372/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.5281/zenodo.10910040
title: ENDOMETRIOZ: SABABLARI, TASNIFI, DAVOLASH, OLDINI OLISH, ASORATLARI VA АYOLLАRNING HАYOT SIFАTINI BАHOLАSH (ADABIYOTLAR TAHLILI)

description: Ginekologik kasalliklar tarkibida endometrioz yallig'lanish kasalliklari va bachadon miomasidan keyin uchinchi o'rinda turadi. Ushbu kasallik bepushtlik bilan og'rigan ayollarning 21-40 foizida tashxis qilinadi, 70-90 foizda surunkali tos a'zolarining og'rig'iga sabab bo'ladi. Shu bilan birga, genital endometrioz. 92-94%, ekstragenital - 6-8% ni tashkil qiladi. Kasallikning yosharishi kuzatilmoqda, endometrioz ko'proq yosh tug'ilgan ayollarda, o'spirinlarda aniqlana boshladi, endometriozni hatto bolalik davrida ham, bachadonda ham aniqlash holatlari tasvirlangan. Shunday qilib, jahon adabiyoti ma'lumotlariga ko'ra yillik kasallanish 0,1-0,3% ni tashkil qiladi
DOI: 10.5281/zenodo.10910041
title: ENDOMETRIOZ: SABABLARI, TASNIFI, DAVOLASH, OLDINI OLISH, ASORATLARI VA АYOLLАRNING HАYOT SIFАTINI BАHOLАSH (ADABIYOTLAR TAHLILI)

description: Ginekologik kasalliklar tarkibida endometrioz yallig'lanish kasalliklari va bachadon miomasidan keyin uchinchi o'rinda turadi. Ushbu kasallik bepushtlik bilan og'rigan ayollarning 21-40 foizida tashxis qilinadi, 70-90 foizda surunkali tos a'zolarining og'rig'iga sabab bo'ladi. Shu bilan birga, genital endometrioz. 92-94%, ekstragenital - 6-8% ni tashkil qiladi. Kasallikning yosharishi kuzatilmoqda, endometrioz ko'proq yosh tug'ilgan ayollarda, o'spirinlarda aniqlana boshladi, endometriozni hatto bolalik davrida ham, bachadonda ham aniqlash holatlari tasvirlangan. Shunday qilib, jahon adabiyoti ma'lumotlariga ko'ra yillik kasallanish 0,1-0,3% ni tashkil qiladi
DOI: 10.15468/dl.p94kw7
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{"type":"and","predicates":[{"type":"equals","key":"TAXON_KEY","value":"6485383","matchCase":false},{"type":"equals","key":"OCCURRENCE_STATUS","value":"PRESENT","matchCase":false},{"type":"equals","key":"HAS_COORDINATE","value":"true","matchCase":false},{"type":"equals","key":"HAS_GEOSPATIAL_ISSUE","value":"false","matchCase":false},{"type":"lessThan","key":"COORDINATE_UNCERTAINTY_IN_METERS","value":"10000","matchCase":false},{"type":"in","key":"YEAR","values":["2008","2009","2010","2011","2012","2013","2014","2015","2016","2017","2018","2019","2020","2021","2022","2023","2024"],"matchCase":false},{"type":"in","key":"BASIS_OF_RECORD","values":["LIVING_SPECIMEN","HUMAN OBSERVATION","OBSERVATION","OCCURRENCE","MACHINE_OBSERVATION"],"matchCase":false}]}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0017104-241024112534372/datasets/export for details.
DOI: 10.15468/dl.6jxk4g
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{"type":"and","predicates":[{"type":"equals","key":"TAXON_KEY","value":"3981803","matchCase":false},{"type":"equals","key":"OCCURRENCE_STATUS","value":"PRESENT","matchCase":false},{"type":"equals","key":"HAS_COORDINATE","value":"true","matchCase":false},{"type":"equals","key":"HAS_GEOSPATIAL_ISSUE","value":"false","matchCase":false},{"type":"lessThan","key":"COORDINATE_UNCERTAINTY_IN_METERS","value":"10000","matchCase":false},{"type":"in","key":"YEAR","values":["2008","2009","2010","2011","2012","2013","2014","2015","2016","2017","2018","2019","2020","2021","2022","2023","2024"],"matchCase":false},{"type":"in","key":"BASIS_OF_RECORD","values":["LIVING_SPECIMEN","HUMAN OBSERVATION","OBSERVATION","OCCURRENCE","MACHINE_OBSERVATION"],"matchCase":false}]}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0017105-241024112534372/datasets/export for details.
DOI: 10.15468/dl.y35dts
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{"type":"and","predicates":[{"type":"equals","key":"TAXON_KEY","value":"7633055","matchCase":false},{"type":"equals","key":"OCCURRENCE_STATUS","value":"PRESENT","matchCase":false},{"type":"equals","key":"HAS_COORDINATE","value":"true","matchCase":false},{"type":"equals","key":"HAS_GEOSPATIAL_ISSUE","value":"false","matchCase":false},{"type":"lessThan","key":"COORDINATE_UNCERTAINTY_IN_METERS","value":"10000","matchCase":false},{"type":"in","key":"YEAR","values":["2008","2009","2010","2011","2012","2013","2014","2015","2016","2017","2018","2019","2020","2021","2022","2023","2024"],"matchCase":false},{"type":"in","key":"BASIS_OF_RECORD","values":["LIVING_SPECIMEN","HUMAN OBSERVATION","OBSERVATION","OCCURRENCE","MACHINE_OBSERVATION"],"matchCase":false}]}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0017103-241024112534372/datasets/export for details.
DOI: 10.15468/dl.7fxgg9
title: Occurrence Download

description: A dataset containing 267 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is Indonesia",
 "HasCoordinate is false",
 "TaxonKey is Coffea L."
 ]
}

 The dataset includes 267 records from 20 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0017101-241024112534372/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.tfk3xs
title: Occurrence Download

description: A dataset containing 6 species occurrences available in GBIF matching the query:
{
 "and" : [
 "GadmGid is IDN",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "TaxonKey is Gonystylus borneensis (Tiegh.) Gilg"
 ]
}

 The dataset includes 6 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0017102-241024112534372/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.pjcwz6
title: Occurrence Download

description: A dataset containing 432 species occurrences available in GBIF matching the query:
{
 "DatasetKey" : [
 "is Données collectées dans le cadre des activités de Locusta-Sorties internes de Locusta (non ouvertes au public)"
 ]
}

 The dataset includes 432 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0017106-241024112534372/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.5281/zenodo.10910059
title: SEMIZLIK QAYT ETILGAN AYOLLARDA ORAL KONTRATSEPTIV VOSITALARDAN FOYDALANISHNING    MUAMMOLARI

description: Semizlik jiddiy tibbiy-ijtimoiy va iqtisodiy muammosi bo‘lib hisoblanadi Ayni paytda ortiqcha tana vazni ayol reproduktiv tizimining endokrin boshqarilishiga, bepushtlikning rivojlanishiga, tuxumdonlar va endometriydagi anomal jarayonlarga, shuningdek, homiladorlik va tug‘ruqning asoratli kechishiga sezilarli darajada salbiy ta’sir ko‘rsatadi. Shuning uchun semizlikning turli tiplari mavjud bo‘lgan ayollarda metabolizmning qayd etilgan xususiyatlarini aniqlash, gormonal dori vositalarining va oral kontraseptivlarni qo‘llanilishida kuzatilgan ba’zi bir jihatlarini inobatga olgan holda davolashning eng maqbul usulini tanlash, ularni qo‘llashning optimal vaqtini belgilash hamda davolashning natijalarini baholash ginekologiya amaliyotida yechimi topilishi zarur
DOI: 10.5281/zenodo.10910060
title: SEMIZLIK QAYT ETILGAN AYOLLARDA ORAL KONTRATSEPTIV VOSITALARDAN FOYDALANISHNING    MUAMMOLARI

description: Semizlik jiddiy tibbiy-ijtimoiy va iqtisodiy muammosi bo‘lib hisoblanadi Ayni paytda ortiqcha tana vazni ayol reproduktiv tizimining endokrin boshqarilishiga, bepushtlikning rivojlanishiga, tuxumdonlar va endometriydagi anomal jarayonlarga, shuningdek, homiladorlik va tug‘ruqning asoratli kechishiga sezilarli darajada salbiy ta’sir ko‘rsatadi. Shuning uchun semizlikning turli tiplari mavjud bo‘lgan ayollarda metabolizmning qayd etilgan xususiyatlarini aniqlash, gormonal dori vositalarining va oral kontraseptivlarni qo‘llanilishida kuzatilgan ba’zi bir jihatlarini inobatga olgan holda davolashning eng maqbul usulini tanlash, ularni qo‘llashning optimal vaqtini belgilash hamda davolashning natijalarini baholash ginekologiya amaliyotida yechimi topilishi zarur
DOI: 10.5281/zenodo.10910085
title: РОЛЬ АУТОИММУННОГО ТИРЕОИДИТА В ГЕНЕЗЕ НЕВЫНАШИВАНИЯ БЕРЕМЕННОСТИ

description: Представлены  гестационные осложнения, особенности плацентарной системы и неонатальный статус у беременных с аутоиммунным тиреоидитом. Установлено, что у беременных с аутоиммунным тиреоидитом достоверно чаще наблюдаются такие осложнения беременности, как угроза прерывания на всех сроках беременности, анемия, гестоз, плацентарная недостаточность, хроническая гипоксия плода. Особенностью течения беременности у женщин с аутоиммунным тиреоидитом является наиболее высокий риск выкидыша до 12 недель гестации. 

Ключевые слова: беременность, аутоиммунный тиреоидит, невынашивание беременности, маточно-плацентарно-плодовый кровоток, плод.
DOI: 10.5281/zenodo.10910086
title: РОЛЬ АУТОИММУННОГО ТИРЕОИДИТА В ГЕНЕЗЕ НЕВЫНАШИВАНИЯ БЕРЕМЕННОСТИ

description: Представлены  гестационные осложнения, особенности плацентарной системы и неонатальный статус у беременных с аутоиммунным тиреоидитом. Установлено, что у беременных с аутоиммунным тиреоидитом достоверно чаще наблюдаются такие осложнения беременности, как угроза прерывания на всех сроках беременности, анемия, гестоз, плацентарная недостаточность, хроническая гипоксия плода. Особенностью течения беременности у женщин с аутоиммунным тиреоидитом является наиболее высокий риск выкидыша до 12 недель гестации. 

Ключевые слова: беременность, аутоиммунный тиреоидит, невынашивание беременности, маточно-плацентарно-плодовый кровоток, плод.
DOI: 10.5281/zenodo.10910099
title: РЕКОНСТРУКТИВНО-ПЛАСТИЧЕСКИЕ ОПЕРАЦИИ ПРИ ЛЕЧЕНИИ ГИПОСПАДИИ В ДЕТСКОМ ВОЗРАСТЕ

description: Аннотация: Гипоспадия - порок развития  полового органа мальчиков , при котором происходить искревление полового члена в сторону мошонки в следствии недоразвития губчатой части уретры. Наружное отверстие находится на нижней поверхности головки полового члена, мошонки или промежности мальчиков. Половой член деформирован и изогнут книзу. Гипоспадия развивается в результате нарушения эмбриогенеза на 7-14 недели внутриутробного развития плода. Тяжелые формы гипоспадии могут сочетаться с нарушением развития внутренних половых органов. Выделяют 3 основные формы гипоспадии, головчатую, стволовую, мошоночную. Примерно в 45% случаев сочетается с другими аномалиями, среди которых первое место занимает крипторхизм, меатостеноз, паховая грыжа. По данным Ю,Ф. Исакова гипоспадия является самой частой аномалией уретры и встречается у 1 из 150 новорожденных мальчиков. По частоте и развития гипоспадия занимает первое место среди аномалией и пороков развития уретры.

Ключевые слова: Гипоспадия, реконструктивно-пластические операции, ультразвуковая диагностика.