cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.6935633
title: Supplementary Material for: Neurogranin and BACE1 in CSF as Potential Biomarkers Differentiating Depression with Cognitive Deficits from Early Alzheimer’s Disease: A Pilot Study

description: <b><i>Background/Aims:</i></b> Major depressive disorder (MDD) can cooccur with early Alzheimer’s disease (AD) or may cause memory problems independently of AD. Previous studies have suggested that the AD-related cerebrospinal fluid (CSF) biomarkers tau and Aβ(1–42) could help discriminate between early AD and depression unrelated to AD. Moreover, the postsynaptic protein neurogranin and presynaptic BACE1 have increasingly gained attention as potential new AD biomarkers, but they have not yet been investigated concerning depression. <b><i>Methods:</i></b> Using ELISAs, we studied CSF neurogranin and BACE1 levels in patients with mild (<i>n</i> = 21) and moderate (<i>n</i> = 19) AD, as well as in MDD patients with (<i>n</i> = 20) and without (<i>n</i> = 20) cognitive deficits. The clinical examinations included analyses of t-tau, Aβ(1–42), and Aβ(1–40), besides neuropsychological tests and cranial magnetic resonance imaging. Depressive symptom severity was assessed using the Geriatric Depression Scale (GDS). <b><i>Results:</i></b> Along with classic AD biomarkers, neurogranin and BACE1 CSF levels differed between moderate AD and MDD (<i>p</i> ≤ 0.01). MDD associated with cognitive deficits was distinguished from mild AD through the CSF neurogranin/BACE1 ratio (<i>p</i> &lt; 0.05), which was strongly correlated with GDS scores (ρ = –0.656; <i>p</i> &lt; 0.01). <b><i>Conclusion:</i></b> The neurogranin/BACE1 ratio in CSF can distinguish between depression and AD among patients with similar cognitive deficits, along with the classic AD biomarkers. Further longitudinal studies are ongoing to identify which biomarkers have prognostic value.
DOI: 10.6084/m9.figshare.6935633.v1
title: Supplementary Material for: Neurogranin and BACE1 in CSF as Potential Biomarkers Differentiating Depression with Cognitive Deficits from Early Alzheimer’s Disease: A Pilot Study

description: <b><i>Background/Aims:</i></b> Major depressive disorder (MDD) can cooccur with early Alzheimer’s disease (AD) or may cause memory problems independently of AD. Previous studies have suggested that the AD-related cerebrospinal fluid (CSF) biomarkers tau and Aβ(1–42) could help discriminate between early AD and depression unrelated to AD. Moreover, the postsynaptic protein neurogranin and presynaptic BACE1 have increasingly gained attention as potential new AD biomarkers, but they have not yet been investigated concerning depression. <b><i>Methods:</i></b> Using ELISAs, we studied CSF neurogranin and BACE1 levels in patients with mild (<i>n</i> = 21) and moderate (<i>n</i> = 19) AD, as well as in MDD patients with (<i>n</i> = 20) and without (<i>n</i> = 20) cognitive deficits. The clinical examinations included analyses of t-tau, Aβ(1–42), and Aβ(1–40), besides neuropsychological tests and cranial magnetic resonance imaging. Depressive symptom severity was assessed using the Geriatric Depression Scale (GDS). <b><i>Results:</i></b> Along with classic AD biomarkers, neurogranin and BACE1 CSF levels differed between moderate AD and MDD (<i>p</i> ≤ 0.01). MDD associated with cognitive deficits was distinguished from mild AD through the CSF neurogranin/BACE1 ratio (<i>p</i> &lt; 0.05), which was strongly correlated with GDS scores (ρ = –0.656; <i>p</i> &lt; 0.01). <b><i>Conclusion:</i></b> The neurogranin/BACE1 ratio in CSF can distinguish between depression and AD among patients with similar cognitive deficits, along with the classic AD biomarkers. Further longitudinal studies are ongoing to identify which biomarkers have prognostic value.
DOI: 10.6084/m9.figshare.6935516
title: Constraints or Complaints? Business Climate and Firm Performance Perceptions in Uganda

description: This paper identifies the business constraints that are most binding for firm performance. Using panel methods on novel quarterly Ugandan business climate data, we exploit perceived changes in business climate constraints to account for changes in firm performance. Not all identified constraints are binding for firm performance. Macroeconomic instability, demand stability, access to finance, corruption/bribery, and weather variability are found to be binding constraints. Firms’ expectations about future performance outcomes are associated with current perceptions about these constraints, alleviating endogeneity concerns to some extent. While taxation constraints are usually highly ranked, we do not find evidence linking them to firm performance.
DOI: 10.6084/m9.figshare.6935516.v1
title: Constraints or Complaints? Business Climate and Firm Performance Perceptions in Uganda

description: This paper identifies the business constraints that are most binding for firm performance. Using panel methods on novel quarterly Ugandan business climate data, we exploit perceived changes in business climate constraints to account for changes in firm performance. Not all identified constraints are binding for firm performance. Macroeconomic instability, demand stability, access to finance, corruption/bribery, and weather variability are found to be binding constraints. Firms’ expectations about future performance outcomes are associated with current perceptions about these constraints, alleviating endogeneity concerns to some extent. While taxation constraints are usually highly ranked, we do not find evidence linking them to firm performance.
DOI: 10.6084/m9.figshare.6935486
title: Museums for the many? Rhetorical optimism and the failure of sustained political will at three London government-funded museums – then and now

description: This article contends that there are considerable similarities between nineteenth- and twenty-first-century aspirations for museums – not least, in respect to promises of “museums for the many”. Despite contemporary policy makers of different political allegiances embracing similar rhetorics, in general they appear to have had little interest in reflecting on previous realities. This article focuses on attendances at three national museums, in particular the British Museum, the National Gallery and, the Victoria & Albert Museum (formerly, the South Kensington Museum) over two periods: from the early 1850s to the late 1880s, and from the late 1970s to the present. It interrogates those and other institutions’ visit data for evidence of whether they did, indeed, deliver to “the many”. It questions the commitment of state-supported museums to those target audiences, both then and now.
DOI: 10.6084/m9.figshare.6935486.v1
title: Museums for the many? Rhetorical optimism and the failure of sustained political will at three London government-funded museums – then and now

description: This article contends that there are considerable similarities between nineteenth- and twenty-first-century aspirations for museums – not least, in respect to promises of “museums for the many”. Despite contemporary policy makers of different political allegiances embracing similar rhetorics, in general they appear to have had little interest in reflecting on previous realities. This article focuses on attendances at three national museums, in particular the British Museum, the National Gallery and, the Victoria & Albert Museum (formerly, the South Kensington Museum) over two periods: from the early 1850s to the late 1880s, and from the late 1970s to the present. It interrogates those and other institutions’ visit data for evidence of whether they did, indeed, deliver to “the many”. It questions the commitment of state-supported museums to those target audiences, both then and now.
DOI: 10.6084/m9.figshare.6935468.v2
title: Dimensions of open research: critical reflections on openness in the ROER4D project

description: Open Research has the potential to advance the scientific process by improving the transparency, rigour, scope and reach of research, but choosing to experiment with Open Research carries with it a set of ideological, legal, technical and operational considerations. Researchers, especially those in resource-constrained situations, may not be aware of the complex interrelations between these different domains of open practice, the additional resources required, or how Open Research can support traditional research practices. Using the Research on Open Educational Resources for Development (ROER4D) project as an example, this paper attempts to demonstrate the interrelation between ideological, legal, technical and operational openness; the resources that conducting Open Research requires; and the benefits of an iterative, strategic approach to one’s own Open Research practice. In this paper we discuss the value of a critical approach towards Open Research to ensure better coherence between ‘open’ ideology (embodied in strategic intention) and ‘open’<br>practice (the everyday operationalisation of open principles).
DOI: 10.6084/m9.figshare.6935441
title: Age-related epigenome-wide DNA methylation and hydroxymethylation in longitudinal mouse blood

description: DNA methylation at cytosine-phosphate-guanine (CpG) dinucleotides changes as a function of age in humans and animal models, a process that may contribute to chronic disease development. Recent studies have investigated the role of an oxidized form of DNA methylation – 5-hydroxymethylcytosine (5hmC) – in the epigenome, but its contribution to age-related DNA methylation remains unclear. We tested the hypothesis that 5hmC changes with age, but in a direction opposite to 5-methylcytosine (5mC), potentially playing a distinct role in aging. To characterize epigenetic aging, genome-wide 5mC and 5hmC were measured in longitudinal blood samples (2, 4, and 10 months of age) from isogenic mice using two sequencing methods – enhanced reduced representation bisulfite sequencing and hydroxymethylated DNA immunoprecipitation sequencing. Examining the epigenome by age, we identified 28,196 unique differentially methylated CpGs (DMCs) and 8,613 differentially hydroxymethylated regions (DHMRs). Mouse blood showed a general pattern of epigenome-wide hypermethylation and hypo-hydroxymethylation with age. Comparing age-related DMCs and DHMRs, 1,854 annotated genes showed both differential 5mC and 5hmC, including one gene – <i>Nfic</i> – at five CpGs in the same 250 bp chromosomal region. At this region, 5mC and 5hmC levels both decreased with age. Reflecting these age-related epigenetic changes, <i>Nfic</i> RNA expression in blood decreased with age, suggesting that age-related regulation of this gene may be driven by 5hmC, not canonical DNA methylation. Combined, our genome-wide results show age-related differential 5mC and 5hmC, as well as some evidence that changes in 5hmC may drive age-related DNA methylation and gene expression.
DOI: 10.6084/m9.figshare.6935441.v2
title: Age-related epigenome-wide DNA methylation and hydroxymethylation in longitudinal mouse blood

description: DNA methylation at cytosine-phosphate-guanine (CpG) dinucleotides changes as a function of age in humans and animal models, a process that may contribute to chronic disease development. Recent studies have investigated the role of an oxidized form of DNA methylation – 5-hydroxymethylcytosine (5hmC) – in the epigenome, but its contribution to age-related DNA methylation remains unclear. We tested the hypothesis that 5hmC changes with age, but in a direction opposite to 5-methylcytosine (5mC), potentially playing a distinct role in aging. To characterize epigenetic aging, genome-wide 5mC and 5hmC were measured in longitudinal blood samples (2, 4, and 10 months of age) from isogenic mice using two sequencing methods – enhanced reduced representation bisulfite sequencing and hydroxymethylated DNA immunoprecipitation sequencing. Examining the epigenome by age, we identified 28,196 unique differentially methylated CpGs (DMCs) and 8,613 differentially hydroxymethylated regions (DHMRs). Mouse blood showed a general pattern of epigenome-wide hypermethylation and hypo-hydroxymethylation with age. Comparing age-related DMCs and DHMRs, 1,854 annotated genes showed both differential 5mC and 5hmC, including one gene – <i>Nfic</i> – at five CpGs in the same 250 bp chromosomal region. At this region, 5mC and 5hmC levels both decreased with age. Reflecting these age-related epigenetic changes, <i>Nfic</i> RNA expression in blood decreased with age, suggesting that age-related regulation of this gene may be driven by 5hmC, not canonical DNA methylation. Combined, our genome-wide results show age-related differential 5mC and 5hmC, as well as some evidence that changes in 5hmC may drive age-related DNA methylation and gene expression.
DOI: 10.6084/m9.figshare.6935441.v1
title: Age-related Epigenome-wide DNA Methylation and Hydroxymethylation in Longitudinal Mouse Blood

description: DNA methylation at cytosine-phosphate-guanine (CpG) dinucleotides changes as a function of age in humans and animal models, a process that may contribute to chronic disease development. Recent studies have investigated the role of an oxidized form of DNA methylation – 5-hydroxymethylcytosine (5hmC) – in the epigenome, but its contribution to age-related DNA methylation remains unclear. We tested the hypothesis that 5hmC changes with age, but in a direction opposite to 5-methylcytosine (5mC), potentially playing a distinct role in aging. To characterize epigenetic aging, genome-wide 5mC and 5hmC were measured in longitudinal blood samples (2, 4, and 10 months of age) from isogenic mice using two sequencing methods – enhanced reduced representation bisulfite sequencing and hydroxymethylated DNA immunoprecipitation sequencing. Examining the epigenome by age, we identified 28,196 unique differentially methylated CpGs (DMCs) and 8,613 differentially hydroxymethylated regions (DHMRs). Mouse blood showed a general pattern of epigenome-wide hypermethylation and hypo-hydroxymethylation with age. Comparing age-related DMCs and DHMRs, 1,854 annotated genes showed both differential 5mC and 5hmC, including one gene – <i>Nfic</i> – at five CpGs in the same 250 bp chromosomal region. At this region, 5mC and 5hmC levels both decreased with age. Reflecting these age-related epigenetic changes, <i>Nfic</i> RNA expression in blood decreased with age, suggesting that age-related regulation of this gene may be driven by 5hmC, not canonical DNA methylation. Combined, our genome-wide results show age-related differential 5mC and 5hmC, as well as some evidence that changes in 5hmC may drive age-related DNA methylation and gene expression.
DOI: 10.6084/m9.figshare.6935195
title: 2013_raw_census_data.xlsx

description: 2013-14 breeding season census data for live pups of the Australian fur seal
DOI: 10.6084/m9.figshare.6935117
title: Additional file 5: of A practical guide for probiotics applied to the case of antibiotic-associated diarrhea in The Netherlands

description: Probiotic products available in The Netherlands. List of probiotic products available in the Netherlands, with information on composition (strains), dosage form, and number of colony-forming units (CFU) per daily dose. (XLSX 54 kb)
DOI: 10.6084/m9.figshare.6935117.v1
title: Additional file 5: of A practical guide for probiotics applied to the case of antibiotic-associated diarrhea in The Netherlands

description: Probiotic products available in The Netherlands. List of probiotic products available in the Netherlands, with information on composition (strains), dosage form, and number of colony-forming units (CFU) per daily dose. (XLSX 54 kb)
DOI: 10.6084/m9.figshare.6935105
title: Additional file 3: of A practical guide for probiotics applied to the case of antibiotic-associated diarrhea in The Netherlands

description: Characteristics of included studies. For every study included in this review, information on study population (number of patients enrolled, age, setting, country, diagnosis and antibiotics prescribed), probiotic treatment (composition, daily dose, intake form, brand, duration of treatment) and outcome (definition of AAD, incidence in probiotic and placebo groups, significance of difference, relative risk) is summarized. (XLSX 39 kb)
DOI: 10.6084/m9.figshare.6935105.v1
title: Additional file 3: of A practical guide for probiotics applied to the case of antibiotic-associated diarrhea in The Netherlands

description: Characteristics of included studies. For every study included in this review, information on study population (number of patients enrolled, age, setting, country, diagnosis and antibiotics prescribed), probiotic treatment (composition, daily dose, intake form, brand, duration of treatment) and outcome (definition of AAD, incidence in probiotic and placebo groups, significance of difference, relative risk) is summarized. (XLSX 39 kb)
DOI: 10.6084/m9.figshare.6935096
title: Additional file 2: of A practical guide for probiotics applied to the case of antibiotic-associated diarrhea in The Netherlands

description: List of reviewed studies. All the clinical trials that were reviewed are listed with indication of first author, publication title, publication date, whether they were included in the review, and, in case, reasons for exclusion. (XLSX 26 kb)
DOI: 10.6084/m9.figshare.6935096.v1
title: Additional file 2: of A practical guide for probiotics applied to the case of antibiotic-associated diarrhea in The Netherlands

description: List of reviewed studies. All the clinical trials that were reviewed are listed with indication of first author, publication title, publication date, whether they were included in the review, and, in case, reasons for exclusion. (XLSX 26 kb)
DOI: 10.6084/m9.figshare.6935087
title: Additional file 1: of A practical guide for probiotics applied to the case of antibiotic-associated diarrhea in The Netherlands

description: Side-effects of antibiotics. List of commonly prescribed antibiotics in The Netherlands, with information on class, mode of action, indication and side effects. (XLSX 29 kb)
DOI: 10.6084/m9.figshare.6935087.v1
title: Additional file 1: of A practical guide for probiotics applied to the case of antibiotic-associated diarrhea in The Netherlands

description: Side-effects of antibiotics. List of commonly prescribed antibiotics in The Netherlands, with information on class, mode of action, indication and side effects. (XLSX 29 kb)
DOI: 10.6084/m9.figshare.6934970
title: The economic value of neighborhoods: Predicting real estate prices from the urban environment

description: Intermediary files and source files for the paper "The economic value of neighborhoods: Predicting real estate prices from the urban environment".<br>
DOI: 10.6084/m9.figshare.6934970.v1
title: The economic value of neighborhoods: Predicting real estate prices from the urban environment

description: Intermediary files and source files for the paper "The economic value of neighborhoods: Predicting real estate prices from the urban environment".<br>
DOI: 10.15468/dl.m3j2c4
title: Occurrence Download

description: A dataset containing 71 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Linum mysorense B.Heyne ex Benth."
 ]
}

 The dataset includes 71 records from 12 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0045428-240321170329656/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.wp9wav
title: Occurrence Download

description: A dataset containing 1340 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is New Zealand",
 "OccurrenceStatus is Present",
 "TaxonKey is Otariidae",
 "Year 2000-2010"
 ]
}

 The dataset includes 1340 records from 9 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0045420-240321170329656/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.dspwts
title: Occurrence Download

description: A dataset containing 106 species occurrences available in GBIF matching the query:
{
 "and" : [
 "BasisOfRecord is Specimen",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "TaxonKey is Phoenicopterus chilensis Molina, 1782"
 ]
}

 The dataset includes 106 records from 21 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0045424-240321170329656/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.2ghz7z
title: Occurrence Download

description: A dataset containing 870 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is Mexico",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "TaxonKey is Olneya tesota A.Gray"
 ]
}

 The dataset includes 870 records from 38 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0045425-240321170329656/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.bh5x4p
title: Occurrence Download

description: A dataset containing 13 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Geometry POLYGON((26.04041 44.3688,26.17413 44.3688,26.17413 44.51337,26.04041 44.51337,26.04041 44.3688))",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "License is CC-BY 4.0",
 "OccurrenceStatus is Present",
 "TaxonKey is Fringilla montifringilla Linnaeus, 1758"
 ]
}

 The dataset includes 13 records from 2 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0045423-240321170329656/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.pf8cbf
title: Occurrence Download

description: A dataset containing 5 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Lobelia acutidens Hook.f."
 ]
}

 The dataset includes 5 records from 4 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0045429-240321170329656/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.s66w4w
title: Occurrence Download

description: A dataset containing 11227 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is Mexico",
 "TaxonKey is Justicia L."
 ]
}

 The dataset includes 11227 records from 203 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0045421-240321170329656/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.bbeprg
title: Occurrence Download

description: A dataset containing 121 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Lysimachia pumila (Baudo) Franch."
 ]
}

 The dataset includes 121 records from 20 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0045426-240321170329656/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.dywb8s
title: Occurrence Download

description: A dataset containing 61 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Limonium carnosum (Boiss.) Kuntze"
 ]
}

 The dataset includes 61 records from 19 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0045427-240321170329656/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.