cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.4225/03/589410cc9089e
title: Prehospital pain: epidemiology and management in Victoria, Australia

description: Pain is a commonly encountered condition in the prehospital and emergency medicine settings, and is associated with significant burden of disease.  This thesis explores the epidemiology of pain in the Victorian prehospital setting, and factors associated with the likelihood of clinically important pain severity reduction were identified from the interrogation of a large patient record database.  Seven factors were found to be associated with the likelihood of clinically important pain reduction following multivariate analyses.  These included: age, time criticality of the patient, pain aetiology, initial pain severity, analgesic agent or combination administered to the patient, scene time, and transport time.  

In 2007, ketamine was trialled in the prehospital setting as an analgesic agent.  In this prospective, randomised controlled trial, the administration of morphine followed by ketamine was found to be superior to morphine alone in the reduction of pain intensity in adult patients with moderate to severe pain following trauma in the prehospital setting.  Intravenous ketamine provided safe and effective analgesia to adult patients following injury. After accounting for differences between trial cluster sites, patients in the ketamine group had a mean verbal numerical rating scale (VNRS) pain reduction of 5.6 points compared with the M-group of 3.2 points (p&lt;0.0001).   

This study followed participants up to 12 months following enrolment into the ketamine study, identified those who continued to suffer from persistent pain, and assessed their health-related quality of life using the SF-36 questionnaire.  Statistically and clinically, there was no difference in the long term follow up between study groups with respect to the summary measures, subscale measures or global pain score. 

In light of the superiority of intravenous ketamine over morphine to reduce pain intensity in patients with moderate to severe traumatic injury, this agent warrants consideration by all emergency medical services (EMS) who have appropriate training and clinical governance.  Furthermore, ketamine was administered in a safe manner in this non-physician EMS setting.  It is likely that this work will result in Ambulance Victoria introducing ketamine as an alternative analgesic agent for the prehospital management of moderate to severe pain in trauma patients, and has the potential to influence change in EMS and emergency medicine practice nationally and internationally.  

In time, hopefully, these studies will make a major contribution to the early management of injured patients. Improved early management of pain and interventions aimed at other related factors could lead to more efficient rehabilitation, demonstrable decreases in morbidity, and improved quality of life.
DOI: 10.4225/03/589412645826f
title: The lost comedian (a novel) & beyond the latticed view:  translating self, memory and place in a second language (exegesis)

description: The thesis consists of two parts, a creative component and an accompanying exegesis.
     My novel, The Lost Comedian, explores a young girl’s struggle to find her own moral compass through a religious crisis, her relationships with her peers and with adults in positions of power. It is mainly set in Sweden in the 1960s and 70s, but also moves back to the 1930s. By the time of her father’s death, the protagonist, Christina, is living a modest life in bay-side Melbourne. She returns to Sweden from Australia for her father’s funeral, and is confronted with her past and memories of growing up in the religious community of Svenstorp. The novel entwines two themes: 1) Christina’s development from a child with a strong sense of belonging and identity as a “Believer” to a teenage rebel, and the consequences of her rebellion; 2) Christina’s recovery from a secret, deeply personal loss that she has encountered in Melbourne, and the ever-present temptations of surrendering to a sense of guilt, punishment and self-destruction as a consequence of the “pagan” way of life to which she surrendered as a teenager in Sweden.  
     The exegesis, “Beyond the Latticed View: Translating Self, Memory and Place in a Second Language,” focuses on the linguistic and cultural translation processes when writing in a second language. Investigating gains and losses of this translation process, the exegesis explores the prospect of a “new” sense of self emerging in the “new” language. Specific Swedish social, literary and cultural influences that inform the novel are discussed in the context of its setting. The exegesis also examines the cultural translation processes that these influences instigate, and how writing from both a spatial and temporal distance when “translating” the past influences the novel. As well, practical translation issues when writing from an “other” culture and language are explored. While reflecting on the many challenges when writing in translation, the exegesis argues that translating “self, memory and place,” ultimately creates a richly rewarding narrative.
DOI: 10.4225/03/58941282d9390
title: Monitoring respiratory function during neonatal resuscitation

description: The studies presented in this thesis show that a RFM can be used during mannequin based neonatal training program to: 1) teach correct mask hold and positioning techniques to diminish leak; 2) teach assessment of PIP and PEEP; 3) teach assessment of tidal volumes and adjustment of PIP to deliver an appropriate tidal volume. During neonatal resuscitation a RFM can provide continuous information about: 1) tidal volume 2) mask or ETT leak, 3) tube placement after endotracheal intubation, 5) the PIP and PEEP being delivered. In addition, I believe it provides valuable information about 1) ventilation rate, 2) inflation and expiration times, 3) the spontaneous breathing patterns, tidal volume and interaction with the inflations. Awards: Winner of the Mollie Holman Doctoral Medal for Excellence, Faculty of  Medicine, Nursing and Health Sciences, 2011.
DOI: 10.5517/ccdc.csd.cc1mhnf6
title: CCDC 1504598: Experimental Crystal Structure Determination

description: Related Article: Michelle A. Kroc, Aditi Patil, Anthony Carlos, Josiah Ballantine, Stephanie Aguilar, Dong-Liang Mo, Heng-Yen Wang, Daniel S. Mueller, Donald J. Wink, Laura L. Anderson|2017|Tetrahedron|73|4125|doi:10.1016/j.tet.2017.01.061
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.14457/cu.the.2007.627
title: การศึกษาเปรียบเทียบการใช้พลังงานของการออกกำลังกายเพื่อสุขภาพชนิดต่างๆ ระหว่างหญิงที่มีภาวะน้ำหนักเกินและหญิงที่มีน้ำหนักปกติ /
DOI: 10.14457/cu.the.2007.631
title: ผลของควันบุหรี่และสารทำความสะอาดฟันเทียม ต่อความแข็งผิวและสีของผิวเคลือบเรซินอะคริลิก /
DOI: 10.14457/kmutt.res.2010.111
title: การพัฒนาเนื้อผลิตภัณฑ์เซรามิกส์จากทรัพยากรธรณีสรรหาใหม่เพื่อเพิ่มผลผลิต /
DOI: 10.4225/03/58941245c3d3d
title: Targeting the NO/sGC/cGMP signaling pathway in health and disease

description: The therapeutic utility of the nitric oxide (NO)/soluble guanylyl cyclase (sGC)/cyclic guanosine 3’5’-monophosphate (cGMP) pathway is well-recognised, with NO donors used in the treatment of diseases such as heart failure, acute hypertensive crisis and pulmonary hypertension. However, traditional nitrovasodilator therapy is somewhat limited due to the development of tolerance following prolonged administration. Furthermore, in vascular disease states such as hypertension, the NO/sGC/cGMP pathway appears to be dysfunctional. Such dysfunction is thought to arise as a consequence of oxidative stress and the associated increase in vascular superoxide anion radical (•O2-) levels, leading to enhanced scavenging of NO to form the oxidant, peroxynitrite (ONOO-). Indeed, ONOO- is able to oxidise the reduced (Fe2+) heme group of sGC, converting it into its NO-insensitive ferric (Fe3+) or heme-free forms. Under such conditions, the efficacy of NO donors/nitrovasodilators are compromised, due to their inability to target these altered states of sGC, underlining the need for novel non-NO based compounds. As such, this thesis examines the vaso-protective actions and therapeutic potential of the redox sibling of NO, nitroxyl (HNO), as well as NO-independent sGC stimulators (BAY 41-2272) and activators (BAY 58-2667) in a number of cardiovascular disease states.
From a clinical perspective, NO-independent compounds such as HNO donors and/or stimulators and activators of sGC may offer considerable therapeutic advantages over traditional nitrovasodilator therapies due to their well-documented resistance to •O2- scavenging and vascular tolerance development, as well as the ability to target oxidised/heme-free sGC (i.e. BAY 58-2667) and the potential to mediate their effects via cGMP-independent mechanisms of action. Such compounds may also offer the basis from which future therapies, for the treatment of cardiovascular diseases, are designed.
DOI: 10.4225/03/589412b9c7a8e
title: Inhibition of oxidative protein folding in gram-negative bacteria : fragment-based design of DsbA inhibitors.

description: The disulfide-dithioloxidoreductase enzyme DsbA is an oxidative folding catalyst found
in the bacterial periplasm and is a key determinant of virulence in Gram-negative
pathogens. DsbA has a wide spectrum of substrate specificity and has been demonstrated
to catalyse the formation of disulfides in numerous secreted proteins. DsbA operates at a
central point in the production of virulence-determinants because most virulence factors
are proteins that require disulfide bonds to be active. DsbA knockout mutants in E. coli,
have been shown to be impaired in a range of processes related to virulence.
Significantly, DsbA mutations in many pathogenic bacteria attenuate their virulence,
demonstrating the value of targeting DsbA to develop anti-bacterial agents to counteract
virulence. DsbA is a structurally as well as functionally well characterized protein which
has no direct homologue in eukaryotes. To date there are no known small molecule
inhibitors of this protein. Hence DsbA represents an attractive antibacterial target and is
the protein of interest for this project.
The current thesis reports the identification of scaffolds that are suitable starting points for
designing inhibitors of DsbA. These scaffolds were identified using a fragment-based
drug design (FBDD) approach. This study describes a structure assisted-FBDD process
performed to validate DsbA as an antibacterial drug target. A broad range of
complementary techniques were employed to identify inhibitors of DsbA from two
different Gram negative bacterial species; Escherichia coli and Vibrio cholerae. NMR
based screening of a fragment library was carried out in two rounds. Theprimary screen
employed STD (Saturation Transfer Difference) experiments to identify candidate hits and 1H-15N HSQC (Heteronuclear Single Quantum Coherence) experiments were used
to confirm binding. A number of strong hits were identified and the binding locations
were identified from the HSQC data. The binding efficiency of the fragments was
determined by calculating NMR-based dissociation constants.Several of these initial
binding fragments also show inhibitory activity in a phenotype assaysin E.coli. X-ray
crystallographic studies revealed that the most potent fragment hits bind in the
hydrophobic groove of EcDsbA in adjacent or overlapping positions.
Charactisation of the structures of complexes of EcDsbA with theoriginal NMR hits was
followed by fragment elaboration through structure-guided medicinal chemistry efforts.
Preliminary structure-activity relationships(SAR) were identified for several series. This
SAR will facilitate the development of novel DsbA inhibitors that specifically target
functionally important protein surface sites.
In conclusion, this study presentsthe discovery of novel small molecule inhibitors of
DsbA and provides insights into the development of potential DsbA inhibitors as
antibacterial drug candidates.
DOI: 10.5281/zenodo.268515
title: Maline

description: About the Data

Overview of Data

This data set contains execution logs of 12,000 Android applications and machine learning feature matrices constructed from them.

Paper Abstract

With Android being the most widespread mobile platform, protecting it against malicious applications is essential. Android users typically install applications from large remote repositories, which provides ample opportunities for malicious newcomers. In this paper, we evaluate a few techniques for detecting malicious Android applications on a repository level. The techniques perform automatic classification based on tracking system calls while applications are executed in a sandbox environment. We implemented the techniques in the maline tool, and performed extensive empirical evaluation on a suite of around 12,000 applications. The evaluation considers the size and type of inputs used in analyses. We show that simple and relatively small inputs result in an overall detection accuracy of 93% with a 5% benign application classification error, while results are improved to a 96% detection accuracy with up-sampling. This indicates that system-call based techniques are viable to be used in practice. Finally, we show that even simplistic feature choices are effective, suggesting that more heavyweight approaches should be thoroughly (re)evaluated.
DOI: 10.5523/bris.2296dq53gzrr72rhk2j46vz6g8
title: Hygroscopic Properties of Aminium Sulphate Aerosols

description: Alkylaminium sulphates originate from the neutralisation reaction between short-chained amines and sulphuric acid and have been detected in atmospheric aerosol particles. Their physicochemical behaviour is less well characterised than their inorganic equivalent, ammonium sulphate, even though they play a role in atmospheric processes such as the nucleation and growth of new particles and cloud droplet formation. In this work, a comparative evaporation kinetics experimental technique using a cylindrical electrodynamic balance is applied to determine the hygroscopic properties of six short-chained alkylaminium sulphates, specifically mono-, di- and tri-methylaminium sulphate and mono-, di- and tri-ethyl aminium sulphate.  This approach allows the retrieval of a water activity dependent growth curve in less than 10 s, avoiding the uncertainties that can arise from the volatilisation of semi-volatile components. Measurements are made on particles &gt;5 m in radius, avoiding the need to correct equilibrium measurements for droplet surface curvature with assumed values of the droplet surface tension. Variations in equilibrium solution droplet composition with varying water activity are reported over the range 0.5 to &gt;0.98, along with accurate parameterisations of solution density and refractive index. The uncertainties in water activities associated with the hygroscopicity measurements are typically 0.9 and ∼±1% below 0.9, with maximum uncertainties in diameter growth factors of ±0.7%. Comparison with previously reported measurements show deviation across the whole water activity range.
DOI: 10.14457/cu.the.2007.634
title: การประยุกต์ใช้แบบจำลองการจัดสรรตำแหน่ง ในการวิเคราะห์กำหนดที่ตั้งสถานีไฟฟ้าและวางแผนระบบสายจำหน่าย /
DOI: 10.17632/xw2c7vvc3n.1
title: Appendix for Master's thesis: LAI development, Reflectance Curves

description: Appendix for Master's thesis. Additional graphs for the ones exemplary printed in the thesis
DOI: 10.4225/08/589802df574bb
title: Silver Nanoparticle Structure Set

description: This is a set of 428 silver nanoparticle INITIAL CONFIGURATIONS, for use in computational studies. These structures have not been optimized or relaxed. Sizes range from 13 Ag atoms to 2947 Ag atoms, with all surfaces remaining clean and unpassivated. All files are in XYZ format, and the naming convention is Ag[number of  atoms]-[shape identifier].xyz .  A spreadsheet is provided in the supporting documents with shape identifiers geometric shape, aspect ratio, average Ag-Ag coordination number, number of Ag-Ag bonds, number of Ag-Ag-Ag angles, and spherically averaged hydrostatic diameter.  Assignment of specific shapes can be ambiguous, particularity for small structures, and so the "best fit" shape has been provided.
DOI: 10.4225/08/58980320a7c53
title: Kinetics of drug binding to hERG at room temperature

description: This collection contains raw data files (pClamp format) relating to the measurement of the kinetics of drug binding to hERG channels at ambient temperatures. Data was acquired on behalf of the Ion Channel Working Group of CiPA, funded by the Safety Pharmacology Society.

A description of methods and implementation is published in the manuscript: Measuring Potency and Kinetics of hERG block for CiPA in Journal of Pharmacological and Toxicological methods.

Abstract:
The Comprehensive in vitro Proarrhythmic assay (CiPA) aims to update current cardiac safety testing to better evaluate arrhythmic risk. A central theme of CiPA is the use of in silico approaches to risk prediction incorporating models of drug binding to hERG. To parameterize these models, accurate in vitro measurement of potency and kinetics of block is required. The Ion Channel Working Group was tasked with: i) selecting a protocol that could measure kinetics of block and was easily implementable on automated platforms for future rollout in industry and ii) acquiring a reference dataset using the standardized protocol. Potency, kinetics and trapping characteristics of hERG block for the CiPA training panel of twelve drugs were measured. Timecourse of block and trapping characteristics could be reliably measured if the time constant for onset of block was between ~500 ms and ~15 sec. Seven drugs, however had time courses of block faster than this cut-off. The dataset from this study is being used by the In Silico Working Group to develop models of drug binding for risk prediction and is being made here freely available as a ‘gold standard’ ambient temperature dataset to evaluate variability across high throughput platforms.
DOI: 10.14457/cu.the.2007.635
title: การวิเคราะห์ภาพรังสีวัดศีรษะด้านข้างในผู้ป่วยไทยกลุ่มหนึ่ง ที่มีภาวะหยุดหายใจขณะหลับ เนื่องจากทางเดินอาหารอุดกั้น /
DOI: 10.14457/cu.the.2007.638
title: การวิเคราะห์ตัวประกอบสมรรถนะของพยาบาลหัวหน้าเวร โรงพยาบาลมหาวิทยาลัยของรัฐ /
DOI: 10.14457/kku.res.2013.40
title: การผลิตน้ำตาลจากวัสดุเหลือทิ้งทางการเกษตร โดยการย่อยสลาย ด้วยเอนไซม์ไซลาเนสจากเชื้อรา
DOI: 10.14457/cu.the.2007.640
title: ความสัมพันธ์ระหว่างภาวะผู้นำเชิงกลยุทธ์ของหัวหน้าหอผู้ป่วย บรรยากาศองค์การกับประสิทธิผลของหอผู้ป่วยตามการรับรู้ของพยาบาลวิชาชีพ โรงพยาบาลมหาวิทยาลัยของรัฐ /
DOI: 10.14457/cu.the.2007.642
title: การนำเสนอยุทธศาสตร์การพัฒนาระบบการจัดการศึกษาระดับอุดมศึกษา ของกองทัพบกเพื่อส่งเสริมความมั่นคงของชาติ /
DOI: 10.15468/ujanoe
title: CHINCHES PATINADORAS (HEMIPTERA: HETEROPTERA: GERRIDAE) DE COLOMBIA: TAXONOMÍA, DISTRIBUCIÓN Y DATOS BIOLÓGICOS

description: Los insectos acuáticos son un grupo bien estudiado en el país ya que cumplen con la función de ser bioindicadores de procesos ambientales tales como contaminación. Sin embargo, las chinches patinadoras (Hemiptera: Gerridae) es un grupo con varias especies por describir y existen vacíos en el conocimiento de la distribución y ecología de las especies para Colombia. Es por esto que se pretende completar el conocimiento de este importante grupo de insectos acuáticos para el país, así como conocer la biología y distribución de las especies.
DOI: 10.5281/zenodo.268540
title: Msr09

description: Overview of Data

This dataset contains the complete SVN repositories for the 69 MSR Prediction Challenge projects.
DOI: 10.14457/cu.the.2007.644
title: บทบาทของยาไธอะโซลิดีนไดโอนต่อความไวของอินสุลิน และผลในการป้องกันเยื่อบุผนังช่องท้องเสื่อมในผู้ป่วยไตวายเรื้อรัง ที่ได้รับการล้างไตทางช่องท้อง /
DOI: 10.14457/sut.res.2014.49
title: มีเทนจากหัวมันและกากมันสำปะหลังเพื่อใช้เป็นแหล่งพลังงาน
DOI: 10.14457/cmu.res.2004.348
title: ความสัมพันธ์ระหว่างรูปแบบการอบรมเลี้ยงดูกับพฤติกรรมก้าวร้าว ในนักเรียนชั้นมัธยมศึกษาตอนต้น จังหวัดเชียงใหม่ /
DOI: 10.14457/kmitl.the.2002.419
title: การศึกษาแนวทางการอนุรักษ์ย่านประวัติศาสตร์ในเมือง กรณีศึกษา เมืองท่าแขก แขวงคำม่วน /
DOI: 10.14457/sut.res.2014.50
title: พอลิเมอร์ไฮโดรเจลสำหรับการประยุกต์เป็นวัสดุเพื่อควบคุมการปล่อยยา
DOI: 10.14457/sut.res.2014.51
title: การบีบอัดข้อมูลในเครือข่ายตรวจรู้ไร้สายสำหรับประยุกต์ใช้งาน ด้านเกษตรกรรมด้วยเทคนิคทางปัญญาประดิษฐ์
DOI: 10.17632/85f9c7x7fw.1
title: Nutritional status of pregnant women at Sidi Bel Abbes, Algeria (2014)

description: Biochemical, hematological and nutritional characteristics of pregnant women in Sidi Bel Abbes (Algeria, 2014)
DOI: 10.4231/r7sf2t6n
title: Stieltjes-Wigert orthogonal polynomials with parameters σ and m

description: Matlab routine for the first N recurrence coefficients of Stieltjes-Wigert orthogonal polynomials with parameters σ and m
DOI: 10.14457/cmu.res.2006.261
title: ความสัมพันธ์ระหว่างรูปแบบการอบรมเลี้ยงดูเด็ก กับพฤติกรรมการแสดงออกที่เหมาะสม ของนักเรียนมัธยมศึกษาตอนปลาย /
DOI: 10.14457/cmu.res.2006.262
title: ความสัมพันธ์ระหว่างรูปแบบการอบรมเลี้ยงดูและพฤติกรรมการดื่มเครื่องดื่มแอลกอฮอล์ ของนักเรียนชั้นมัธยมศึกษาตอนปลาย /
DOI: 10.14457/kmitl.the.2002.417
title: บทเรียนผ่านระบบอินเทอร์เน็ตวิชาระบบการจัดการฐานข้อมูล /
DOI: 10.14457/kmitl.the.2002.418
title: การจัดสรรช่องสัญญาณแบบพลวัตลักษณะกระจายการควบคุมในเครือข่ายระบบเซลลูล่าร์ที่รองรับบริการมัลติมิเดีย /
DOI: 10.14457/kmitl.the.2002.420
title: บทเรียนวีดิทัศน์ เรื่อง เทคนิคในการพิมพ์ดีด /
DOI: 10.4231/r7np22fv
title: 32-digit values of the first 100 recurrence coefficients for the upper subrange Hermite weight function on [c,Inf], c=√1/2

description: 32-digit values of the first 100 recurrence coefficients for the weight function w(x)=exp(-x^2) on [c,Inf], c=√1/2
DOI: 10.4231/r7x63jxz
title: Monic Hahn orthogonal polynomials with parameters N, a, and b

description: Matlab routine for the N+1 recurrence coefficients of monic Hahn orthogonal polynomials with parameters N, a, and b
DOI: 10.5281/zenodo.268538
title: Msr08

description: Overview of Data

Eclipse: 5 files, ~7GB, possibly update from 2007 MSR

The first four of these files are CVS repository dumps form Eclipse-JDT, Eclipse-SWT, Eclipse-Platform, and Eclipse-Rest. In order to mine these, you will need to have a means of handling CVS repositories. These files are listed as:


	eclipse-cvs-jdt.tgz
	eclipse-cvs-swt.tgz
	eclipse-cvs-plarform.tgz
	eclipse-cvs-rest.tgz


The fifth data file XML bug reports dumped from the Eclipse Bugzilla page. It is listed as:


	eclipse-bugs-000001-213000.zip
DOI: 10.14457/cmu.res.2008.340
title: ความสัมพันธ์ระหว่างรูปแบบภาวะผู้นำ กับผลการพัฒนาคณาจารย์ ของมหาวิทยาลัยแม่โจ้ /
DOI: 10.14457/cu.the.2007.641
title: พัฒนาการของมหาวิทยาลัยไทย พ.ศ.2459-2500 /
DOI: 10.14457/cu.the.2007.643
title: ตำนานพระเจ้าห้าพระองค์ : โครงสร้าง เนื้อหา และบทบาทในสังคมไทย /
DOI: 10.14457/kmitl.the.2002.421
title: การใช้พรรณไม้เพื่อปรับปรุงคุณภาพอากาศในท้องถนนของเมือง กรณีศึกษา : ถนนสีลม /