cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.17615/6zrg-y832
title: Non-invasive 4D transcranial contrast-enhanced functional ultrasound imaging in mice with Alzheimer’s Disease during vibrotactile stimulation (Part 17)

description: Functional ultrasound (fUS) is an imaging technique that can measure changes in cerebral blood flow (CBF). However, transcranial ultrasound imaging is challenging due to the aberration and reverberation of sound due to the skull. Microbubble contrast-enhancement can overcome sensitivity limitations. Here, we propose a completely non-invasive 4D contrast-enhanced fUS approach to image brain hemodynamics at high spatial (200 um) and temporal resolutions (20 ms), providing a method to better study the localized changes in brain activity. The capabilities of this technique are demonstrated in Alzheimer's Disease (AD), a neurodegenerative disorder that is one of the leading causes of disability and death. Compared to conventional neuroimaging tools that are used for diagnosis and monitoring the proposed technique has higher spatial and temporal resolution. To demonstrate the capabilities of this contrast-enhanced fUS technique to transcranially image volumetric cerebral hemodynamics, it was applied to five wild-type (WT) mice and five mice with AD at rest (baseline) during vibrotactile stimulation of the front or hind paw. WT mice, on average, experienced 10.7-23.9 % higher mean CBF for each stimulation case but 17.0-20.3 % lower mean connectivity than mice with AD. Five specific regions were highlighted in this comparison that are known to be affected by AD. These were the entorhinal cortex, hippocampus, thalamus, parietal cortex, and frontal cortex. AD mice exhibited hyper-connectivity in the hippocampus, one of the first regions affected by AD in this mouse model, and lower CBF in all five regions. Both the CBF and connectivity results from this technique agree with published gold-standard fMRI AD findings that account for the age of the animals. In summary, it is demonstrated that 4D fUS can non-invasively detect and monitor changes in cerebral hemodynamics associated with AD with high temporal resolution, enabling longitudinal functional assessments of these effects in rodent AD models.
DOI: 10.17615/w87a-3c11
title: Non-invasive 4D transcranial contrast-enhanced functional ultrasound imaging in mice with Alzheimer’s Disease during vibrotactile stimulation (Part 18)

description: Functional ultrasound (fUS) is an imaging technique that can measure changes in cerebral blood flow (CBF). However, transcranial ultrasound imaging is challenging due to the aberration and reverberation of sound due to the skull. Microbubble contrast-enhancement can overcome sensitivity limitations. Here, we propose a completely non-invasive 4D contrast-enhanced fUS approach to image brain hemodynamics at high spatial (200 um) and temporal resolutions (20 ms), providing a method to better study the localized changes in brain activity. The capabilities of this technique are demonstrated in Alzheimer's Disease (AD), a neurodegenerative disorder that is one of the leading causes of disability and death. Compared to conventional neuroimaging tools that are used for diagnosis and monitoring the proposed technique has higher spatial and temporal resolution. To demonstrate the capabilities of this contrast-enhanced fUS technique to transcranially image volumetric cerebral hemodynamics, it was applied to five wild-type (WT) mice and five mice with AD at rest (baseline) during vibrotactile stimulation of the front or hind paw. WT mice, on average, experienced 10.7-23.9 % higher mean CBF for each stimulation case but 17.0-20.3 % lower mean connectivity than mice with AD. Five specific regions were highlighted in this comparison that are known to be affected by AD. These were the entorhinal cortex, hippocampus, thalamus, parietal cortex, and frontal cortex. AD mice exhibited hyper-connectivity in the hippocampus, one of the first regions affected by AD in this mouse model, and lower CBF in all five regions. Both the CBF and connectivity results from this technique agree with published gold-standard fMRI AD findings that account for the age of the animals. In summary, it is demonstrated that 4D fUS can non-invasively detect and monitor changes in cerebral hemodynamics associated with AD with high temporal resolution, enabling longitudinal functional assessments of these effects in rodent AD models.
DOI: 10.15468/dl.ysmqyd
title: Occurrence Download

description: A dataset containing 238677 species occurrences available in GBIF matching the query:
{
 "DatasetKey" : [
 "is Nigeria Bird Atlas (Full Protocol Submissions)"
 ]
}

 The dataset includes 238677 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0030940-240626123714530/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.5517/ccdc.csd.cc232jzq
title: CCDC 1938863: Experimental Crystal Structure Determination

description: Related Article: R.J. Puddephatt, A. Behnia, M.A. Fard|2019|CSD Communication|||
description: Related Article: Ava Behnia, Mahmood Azizpoor Fard, Richard J. Puddephatt|2019|J.Organomet.Chem.|902|120962|doi:10.1016/j.jorganchem.2019.120962
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc236mvt
title: CCDC 1942796: Experimental Crystal Structure Determination

description: Related Article: Qi-Pin Qin, Zhen-Feng Wang, Xiao-Ling Huang, Ming-Xiong Tan, Bi-Qun Zou, Hong Liang|2019|Eur.J.Med.Chem.|184|111751|doi:10.1016/j.ejmech.2019.111751
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc236mwv
title: CCDC 1942797: Experimental Crystal Structure Determination

description: Related Article: Qi-Pin Qin, Zhen-Feng Wang, Xiao-Ling Huang, Ming-Xiong Tan, Bi-Qun Zou, Hong Liang|2019|Eur.J.Med.Chem.|184|111751|doi:10.1016/j.ejmech.2019.111751
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc236myx
title: CCDC 1942799: Experimental Crystal Structure Determination

description: Related Article: Qi-Pin Qin, Zhen-Feng Wang, Xiao-Ling Huang, Ming-Xiong Tan, Bi-Qun Zou, Hong Liang|2019|Eur.J.Med.Chem.|184|111751|doi:10.1016/j.ejmech.2019.111751
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc236mzy
title: CCDC 1942800: Experimental Crystal Structure Determination

description: Related Article: Qi-Pin Qin, Zhen-Feng Wang, Xiao-Ling Huang, Ming-Xiong Tan, Bi-Qun Zou, Hong Liang|2019|Eur.J.Med.Chem.|184|111751|doi:10.1016/j.ejmech.2019.111751
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc236n00
title: CCDC 1942801: Experimental Crystal Structure Determination

description: Related Article: Qi-Pin Qin, Zhen-Feng Wang, Xiao-Ling Huang, Ming-Xiong Tan, Bi-Qun Zou, Hong Liang|2019|Eur.J.Med.Chem.|184|111751|doi:10.1016/j.ejmech.2019.111751
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc237zhv
title: CCDC 1944087: Experimental Crystal Structure Determination

description: Related Article: Jahar Lal Pratihar, Paritosh Mandal, Chia-Her Lin|2019|Polyhedron|173|114102|doi:10.1016/j.poly.2019.07.047
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc23bz7p
title: CCDC 1946962: Experimental Crystal Structure Determination

description: Related Article: R.J. Puddephatt, A. Abo-Amer, P.D. Boyle|2019|CSD Communication|||
description: Related Article: Anwar Abo-Amer, Paul D. Boyle, Richard J. Puddephatt|2021|Inorg.Chim.Acta|522|120387|doi:10.1016/j.ica.2021.120387
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc23bz8q
title: CCDC 1946963: Experimental Crystal Structure Determination

description: Related Article: R.J. Puddephatt, A. Abo-Amer, P.D. Boyle|2019|CSD Communication|||
description: Related Article: Anwar Abo-Amer, Paul D. Boyle, Richard J. Puddephatt|2021|Inorg.Chim.Acta|522|120387|doi:10.1016/j.ica.2021.120387
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc23bz9r
title: CCDC 1946964: Experimental Crystal Structure Determination

description: Related Article: R.J. Puddephatt, A. Abo-Amer, P.D. Boyle|2019|CSD Communication|||
description: Related Article: Anwar Abo-Amer, Paul D. Boyle, Richard J. Puddephatt|2021|Inorg.Chim.Acta|522|120387|doi:10.1016/j.ica.2021.120387
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc23bzbs
title: CCDC 1946965: Experimental Crystal Structure Determination

description: Related Article: R.J. Puddephatt, A. Abo-Amer, P.D. Boyle|2019|CSD Communication|||
description: Related Article: Anwar Abo-Amer, Paul D. Boyle, Richard J. Puddephatt|2021|Inorg.Chim.Acta|522|120387|doi:10.1016/j.ica.2021.120387
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc23bzct
title: CCDC 1946966: Experimental Crystal Structure Determination

description: Related Article: R.J. Puddephatt, A. Abo-Amer, P.D. Boyle|2019|CSD Communication|||
description: Related Article: Anwar Abo-Amer, Paul D. Boyle, Richard J. Puddephatt|2021|Inorg.Chim.Acta|522|120387|doi:10.1016/j.ica.2021.120387
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc23cv2f
title: CCDC 1947794: Experimental Crystal Structure Determination

description: Related Article: Atsushi Kobayashi, Shin-ichiro Imada, Yasuhiro Shigeta, Yuki Nagao, Masaki Yoshida, Masako Kato|2019|J.Mater.Chem.C|7|14923|doi:10.1039/C9TC04944D
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc23f3rf
title: CCDC 1949024: Experimental Crystal Structure Determination

description: Related Article: Emilia Kuzniak, James Hooper, Monika Srebro-Hooper, Jedrzej Kobylarczyk, Magdalena Dziurka, Bogdan Musielak, Dawid Pinkowicz, Jesus Raya, Sylvie Ferlay, Robert Podgajny
|2020|Inorg.Chem.Front.|7|1851|doi:10.1039/D0QI00101E
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc23f3sg
title: CCDC 1949025: Experimental Crystal Structure Determination

description: Related Article: Emilia Kuzniak, James Hooper, Monika Srebro-Hooper, Jedrzej Kobylarczyk, Magdalena Dziurka, Bogdan Musielak, Dawid Pinkowicz, Jesus Raya, Sylvie Ferlay, Robert Podgajny
|2020|Inorg.Chem.Front.|7|1851|doi:10.1039/D0QI00101E
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc23f3th
title: CCDC 1949026: Experimental Crystal Structure Determination

description: Related Article: Emilia Kuzniak, James Hooper, Monika Srebro-Hooper, Jedrzej Kobylarczyk, Magdalena Dziurka, Bogdan Musielak, Dawid Pinkowicz, Jesus Raya, Sylvie Ferlay, Robert Podgajny
|2020|Inorg.Chem.Front.|7|1851|doi:10.1039/D0QI00101E
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc23f3vj
title: CCDC 1949027: Experimental Crystal Structure Determination

description: Related Article: Emilia Kuzniak, James Hooper, Monika Srebro-Hooper, Jedrzej Kobylarczyk, Magdalena Dziurka, Bogdan Musielak, Dawid Pinkowicz, Jesus Raya, Sylvie Ferlay, Robert Podgajny
|2020|Inorg.Chem.Front.|7|1851|doi:10.1039/D0QI00101E
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc23fkpt
title: CCDC 1949456: Experimental Crystal Structure Determination

description: Related Article: Braden A. Zahora, Michael R. Gau, Karen I. Goldberg|2020|Organometallics|39|1230|doi:10.1021/acs.organomet.0c00023
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc23flcj
title: CCDC 1949477: Experimental Crystal Structure Determination

description: Related Article: Braden A. Zahora, Michael R. Gau, Karen I. Goldberg|2020|Organometallics|39|1230|doi:10.1021/acs.organomet.0c00023
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc23fpcm
title: CCDC 1949570: Experimental Crystal Structure Determination

description: Related Article: Aisling L. Ryan, Marie-Claire Fitzgerald, András Ozsváth, Brendan Twamley, Péter Buglyó, Brona M. Murphy, Darren M. Griffith|2019|Inorg.Chem.|58|16075|doi:10.1021/acs.inorgchem.9b02632
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc23fpdn
title: CCDC 1949571: Experimental Crystal Structure Determination

description: Related Article: Aisling L. Ryan, Marie-Claire Fitzgerald, András Ozsváth, Brendan Twamley, Péter Buglyó, Brona M. Murphy, Darren M. Griffith|2019|Inorg.Chem.|58|16075|doi:10.1021/acs.inorgchem.9b02632
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc23g3g5
title: CCDC 1949976: Experimental Crystal Structure Determination

description: Related Article: Karoline Mueller, Christina Schütz, Tobias Rüffer, Martin Bette, Goran N. Kaluđerović, Dirk Steinborn, Harry Schmidt|2020|Inorg.Chim.Acta|507|119539|doi:10.1016/j.ica.2020.119539
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc23kh6d
title: CCDC 1953223: Experimental Crystal Structure Determination

description: Related Article: Umut Doğan, Özge Özcan, Gizem Alaca, Aydan Arı, Salih Günnaz, H. Tansel Yalçın, Onur Şahin, Sevil İrişli|2021|J.Mol.Struct.|1229|129785|doi:10.1016/j.molstruc.2020.129785
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc23gydy
title: CCDC 1950780: Experimental Crystal Structure Determination

description: Related Article: Krishna Mistry, Paul G. Pringle, Hazel A. Sparkes, Duncan F. Wass|2020|Organometallics|39|468|doi:10.1021/acs.organomet.9b00568
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc23kh7f
title: CCDC 1953224: Experimental Crystal Structure Determination

description: Related Article: Umut Doğan, Özge Özcan, Gizem Alaca, Aydan Arı, Salih Günnaz, H. Tansel Yalçın, Onur Şahin, Sevil İrişli|2021|J.Mol.Struct.|1229|129785|doi:10.1016/j.molstruc.2020.129785
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc23b5tg
title: CCDC 1946205: Experimental Crystal Structure Determination

description: Related Article: Maria V. Kashina, Mikhail A. Kinzhalov, Andrey S. Smirnov, Daniil M. Ivanov, Alexander S. Novikov, Vadim Yu. Kukushkin|2019|Chem.Asian J.|14|3915|doi:10.1002/asia.201901127
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc23b6c1
title: CCDC 1946222: Experimental Crystal Structure Determination

description: Related Article: Maria V. Kashina, Mikhail A. Kinzhalov, Andrey S. Smirnov, Daniil M. Ivanov, Alexander S. Novikov, Vadim Yu. Kukushkin|2019|Chem.Asian J.|14|3915|doi:10.1002/asia.201901127
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc23m20v
title: CCDC 1954736: Experimental Crystal Structure Determination

description: Related Article: Guijie Li, Feng Zhan, Jianbing Zheng, Yun-Fang Yang, Qunmin Wang, Qidong Chen, Gang Shen, Yuanbin She|2020|Inorg.Chem.|59|3718|doi:10.1021/acs.inorgchem.9b03376
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.