cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.19229274
title: Bcl-2 interacting protein 3 (BNIP3) promotes tumor growth in breast cancer under hypoxic conditions through an autophagy-dependent pathway

description: Hypoxia-induced autophagy has been implicated in many cancers. Bcl-2 interacting protein 3 (BNIP3) has been associated with hypoxia, whose aberrant expression is involved in the carcinogenesis of breast cancer (BC). Here, we aim to investigate the role of hypoxia-induced autophagy and the mechanistic actions of the bioinformatically identified BNIP3 in BC. The expression pattern of BNIP3 in BC tissues and cell lines was examined using RT-qPCR and Western blot analyses. The binding affinity among BNIP3, BECN1 and BCL-2 was characterized by co-immunoprecipitation. BNIP3 expression was manipulated to assess its effects on BC cell malignant phenotypes, evaluated by cell counting kit-8, Transwell and wound healing assays, and on BC autophagy under hypoxic conditions. A BC tumor xenografts mouse model was further established to substantiate <i>in vitro</i> findings. Up-regulated expression of BNIP3 was found in BC tissues and cell lines, and BNIP3 expression was positively correlated with hypoxia exposure duration. BNIP3 knockdown restricted BC cell proliferation, invasion, and migration under hypoxic conditions. BNIP3 activated BC cell autophagy by inhibiting the binding between BCL-2 and BECN1 under hypoxic conditions. BNIP3-induced autophagy activation enhanced malignant phenotypes of BC cells, thus accelerating the tumorigenesis of BC cells <i>in vivo</i>. These data collectively supported the tumor-promoting role of BNIP3 in autophagy activation of BC under hypoxic conditions, highlighting a potential therapeutic target against BC.
DOI: 10.6084/m9.figshare.19229274.v1
title: Bcl-2 interacting protein 3 (BNIP3) promotes tumor growth in breast cancer under hypoxic conditions through an autophagy-dependent pathway

description: Hypoxia-induced autophagy has been implicated in many cancers. Bcl-2 interacting protein 3 (BNIP3) has been associated with hypoxia, whose aberrant expression is involved in the carcinogenesis of breast cancer (BC). Here, we aim to investigate the role of hypoxia-induced autophagy and the mechanistic actions of the bioinformatically identified BNIP3 in BC. The expression pattern of BNIP3 in BC tissues and cell lines was examined using RT-qPCR and Western blot analyses. The binding affinity among BNIP3, BECN1 and BCL-2 was characterized by co-immunoprecipitation. BNIP3 expression was manipulated to assess its effects on BC cell malignant phenotypes, evaluated by cell counting kit-8, Transwell and wound healing assays, and on BC autophagy under hypoxic conditions. A BC tumor xenografts mouse model was further established to substantiate <i>in vitro</i> findings. Up-regulated expression of BNIP3 was found in BC tissues and cell lines, and BNIP3 expression was positively correlated with hypoxia exposure duration. BNIP3 knockdown restricted BC cell proliferation, invasion, and migration under hypoxic conditions. BNIP3 activated BC cell autophagy by inhibiting the binding between BCL-2 and BECN1 under hypoxic conditions. BNIP3-induced autophagy activation enhanced malignant phenotypes of BC cells, thus accelerating the tumorigenesis of BC cells <i>in vivo</i>. These data collectively supported the tumor-promoting role of BNIP3 in autophagy activation of BC under hypoxic conditions, highlighting a potential therapeutic target against BC.
DOI: 10.17632/yhgjvf8ynp
title: LACK OF AN EFFECTIVE LEGAL REMEDY AGAINST ARBITRARY RESOLUTIONS OF THE INTER-AMERICAN COMMISSION ON HUMAN RIGHTS

description: This article contends that the institutional design of the Inter-American Human Rights System (IAHRS) suffers from a serious procedural asymmetry because it offers member states no effective legal remedy to challenge arbitrary resolutions of the Inter-American Commission on Human Rights (IACHR), such as precautionary measures or final reports. By analyzing emblematic cases from Guatemala, Brazil, Peru, Uruguay and Argentina, it shows how this omission undermines state sovereignty, generates legal uncertainty and fosters perceptions of arbitrariness. The Commission accumulates investigatory, accusatory and decision-making functions without independent judicial oversight, which contradicts fundamental principles of due process and weakens the legitimacy of the system. As a solution, the article proposes creating a mechanism of judicial review within the Inter-American Court of Human Rights to ensure impartial scrutiny of certain Commission resolutions, thereby balancing the protection of human rights with procedural guarantees for states.
DOI: 10.17632/yhgjvf8ynp.1
title: LACK OF AN EFFECTIVE LEGAL REMEDY AGAINST ARBITRARY RESOLUTIONS OF THE INTER-AMERICAN COMMISSION ON HUMAN RIGHTS

description: This article contends that the institutional design of the Inter-American Human Rights System (IAHRS) suffers from a serious procedural asymmetry because it offers member states no effective legal remedy to challenge arbitrary resolutions of the Inter-American Commission on Human Rights (IACHR), such as precautionary measures or final reports. By analyzing emblematic cases from Guatemala, Brazil, Peru, Uruguay and Argentina, it shows how this omission undermines state sovereignty, generates legal uncertainty and fosters perceptions of arbitrariness. The Commission accumulates investigatory, accusatory and decision-making functions without independent judicial oversight, which contradicts fundamental principles of due process and weakens the legitimacy of the system. As a solution, the article proposes creating a mechanism of judicial review within the Inter-American Court of Human Rights to ensure impartial scrutiny of certain Commission resolutions, thereby balancing the protection of human rights with procedural guarantees for states.
DOI: 10.17632/v8byjvp5bv
title: THE EUROPEAN HUMAN RIGHTS PROTECTION SYSTEM AS A MODEL FOR REFORMING THE INTER-AMERICAN SYSTEM

description: This article discusses the relevance of the European Human Rights Protection System as a model for reforming the Inter-American System. It highlights how both systems emerged after the Second World War to prevent human-rights violations, with the European system standing out for its effectiveness. The structure and operation of both systems are analyzed, noting that the European system has been more effective in implementing judgments and influencing national legislation. Despite challenges in the Inter-American System, such as the implementation of
decisions and limited resources, it is suggested that the system can be strengthened through reforms inspired by the European model. These include improving the implementation of judgments, increasing efficiency in handling cases, expanding jurisprudence and encouraging civil-society participation. It is argued that such reforms would greatly enhance the Inter-American System’s effectiveness in protecting and promoting human rights in the Americas.
DOI: 10.17632/v8byjvp5bv.1
title: THE EUROPEAN HUMAN RIGHTS PROTECTION SYSTEM AS A MODEL FOR REFORMING THE INTER-AMERICAN SYSTEM

description: This article discusses the relevance of the European Human Rights Protection System as a model for reforming the Inter-American System. It highlights how both systems emerged after the Second World War to prevent human-rights violations, with the European system standing out for its effectiveness. The structure and operation of both systems are analyzed, noting that the European system has been more effective in implementing judgments and influencing national legislation. Despite challenges in the Inter-American System, such as the implementation of
decisions and limited resources, it is suggested that the system can be strengthened through reforms inspired by the European model. These include improving the implementation of judgments, increasing efficiency in handling cases, expanding jurisprudence and encouraging civil-society participation. It is argued that such reforms would greatly enhance the Inter-American System’s effectiveness in protecting and promoting human rights in the Americas.
DOI: 10.17632/c5429jd3hw.3
title: "Supplementary Figures for Atypical fibroxanthoma, pleomorphic dermal sarcoma, and undifferentiated sarcoma: Updates on diagnosis, management, and surveillance"

description: Atypical fibroxanthoma, pleomorphic dermal sarcoma, undifferentiated sarcoma Whole Section and High Power H&E Images
DOI: 10.17632/yx3jt7ggp9
title: Lower Public Awareness of Hidradenitis Suppurativa in U.S. Hispanic Populations

description: This repository contains the raw state-level dataset and supplementary figures used in the analysis of U.S. public awareness of hidradenitis suppurativa (HS). Data include Google Trends state-level relative search interest scores (2004–2023) and corresponding demographic, socioeconomic, and health-related variables derived from U.S. Census and publicly available sources. Supplementary figures display Pearson correlation plots between HS search interest and key state-level variables, including smoking prevalence, obesity prevalence, racial and ethnic composition, and insurance status. These materials support the analyses and findings presented in the accompanying manuscript.
DOI: 10.17632/yx3jt7ggp9.1
title: Lower Public Awareness of Hidradenitis Suppurativa in U.S. Hispanic Populations

description: This repository contains the raw state-level dataset and supplementary figures used in the analysis of U.S. public awareness of hidradenitis suppurativa (HS). Data include Google Trends state-level relative search interest scores (2004–2023) and corresponding demographic, socioeconomic, and health-related variables derived from U.S. Census and publicly available sources. Supplementary figures display Pearson correlation plots between HS search interest and key state-level variables, including smoking prevalence, obesity prevalence, racial and ethnic composition, and insurance status. These materials support the analyses and findings presented in the accompanying manuscript.
DOI: 10.17632/wfssjzws8d
title: TN Data

description: TN Data
DOI: 10.17632/wfssjzws8d.1
title: TN Data

description: TN Data
DOI: 10.5281/zenodo.18375372
title: Instances for the two-stage fixed-charge transportation problem

description: This repository contains a collection of instance files used in the computational experiments reported in:

Calvete, H. I., Galé, C., Iranzo, J. A., & Toth, P. (2018). A matheuristic for the two-stage fixed-charge transportation problem. Computers & Operations Research, 95, 113–122.

The instances correspond to large-scale test cases for the two-stage fixed-charge transportation problem and are provided as plain text files.

File name convention

Each .txt file name follows the format pN_I_J_K.txt, where N is the instance number, I is the number of plants, J is the number of depots, and K is the number of customers.

For example, the file p1_2_4_6.txt corresponds to instance 1 with I = 2 plants, J = 4 depots and K = 6 customers.

File structure

Each .txt file contains all the data required to define one instance of the problem, organized as follows:



I, J, K: integer values indicating the number of plants, depots and customers, respectively.

demand: a vector of length K specifying the demand of each customer.

supply: a vector of length I specifying the production capacity of each plant.

variableCost1: an I × J matrix where element (i, j) represents the unit variable transportation cost from plant i to depot j.

variableCost2: a J × K matrix where element (j, k) represents the unit variable transportation cost from depot j to customer k.

fixedCost1: an I × J matrix where element (i, j) represents the fixed cost incurred if the link from plant i to depot j is used.

fixedCost2: a J × K matrix where element (j, k) represents the fixed cost incurred if the link from depot j to customer k is used.


Contact

For any questions or further information regarding these instances, please contact José A. Iranzo at joseani@unizar.es
DOI: 10.5281/zenodo.18375373
title: Instances for the two-stage fixed-charge transportation problem

description: This repository contains a collection of instance files used in the computational experiments reported in:

Calvete, H. I., Galé, C., Iranzo, J. A., & Toth, P. (2018). A matheuristic for the two-stage fixed-charge transportation problem. Computers & Operations Research, 95, 113–122.

The instances correspond to large-scale test cases for the two-stage fixed-charge transportation problem and are provided as plain text files.

File name convention

Each .txt file name follows the format pN_I_J_K.txt, where N is the instance number, I is the number of plants, J is the number of depots, and K is the number of customers.

For example, the file p1_2_4_6.txt corresponds to instance 1 with I = 2 plants, J = 4 depots and K = 6 customers.

File structure

Each .txt file contains all the data required to define one instance of the problem, organized as follows:



I, J, K: integer values indicating the number of plants, depots and customers, respectively.

demand: a vector of length K specifying the demand of each customer.

supply: a vector of length I specifying the production capacity of each plant.

variableCost1: an I × J matrix where element (i, j) represents the unit variable transportation cost from plant i to depot j.

variableCost2: a J × K matrix where element (j, k) represents the unit variable transportation cost from depot j to customer k.

fixedCost1: an I × J matrix where element (i, j) represents the fixed cost incurred if the link from plant i to depot j is used.

fixedCost2: a J × K matrix where element (j, k) represents the fixed cost incurred if the link from depot j to customer k is used.


Contact

For any questions or further information regarding these instances, please contact José A. Iranzo at joseani@unizar.es
DOI: 10.17632/2zm8v7nnj3
title: THE POTENTIAL FOR MITIGATING THE IMPACTS OF MICROCLIMATE REGULATION URBANIZATION IN SUBURBAN CITIES.

description: This repository contains the data that support the results presented in the manuscript submitted to Trees, Forests and People, which it is titled THE POTENTIAL FOR MITIGATING THE IMPACTS OF MICROCLIMATE REGULATION URBANIZATION IN INTERMEDIATE CITIES. The dataset includes field measurements, processed data tables, and analysis scripts used to assess the structure of urban forests and associated ecosystem services.
DOI: 10.17632/2zm8v7nnj3.1
title: THE POTENTIAL FOR MITIGATING THE IMPACTS OF MICROCLIMATE REGULATION URBANIZATION IN SUBURBAN CITIES.

description: This repository contains the data that support the results presented in the manuscript submitted to Trees, Forests and People, which it is titled THE POTENTIAL FOR MITIGATING THE IMPACTS OF MICROCLIMATE REGULATION URBANIZATION IN INTERMEDIATE CITIES. The dataset includes field measurements, processed data tables, and analysis scripts used to assess the structure of urban forests and associated ecosystem services.
DOI: 10.17632/nfgkgkw2f7
title: All publications

description: All publications from Google scholar until 01.2026
DOI: 10.17632/nfgkgkw2f7.1
title: All publications

description: All publications from Google scholar until 01.2026
DOI: 10.17632/93pfpppm6f
title: Linguistic Features of Climate Video Messages and Dietary Motivation

description: This dataset supports a study investigating how linguistic features embedded in climate-related short video messages influence climate-friendly dietary motivation among Chinese young adults. Participants (N = 711) were randomly assigned to view six short videos promoting sustainable eating and reported their motivational responses after each video.

The dataset is structured at two levels. Level 1 data consist of repeated observations at the video-viewing level, including post-viewing dietary motivation measures and linguistic characteristics of each video derived from the Linguistic Inquiry and Word Count (LIWC) dictionary, covering emotional, motivational, and cognitive word categories. Level 2 data include participant-level information, such as demographic variables (e.g., age, gender, education) and psychological measures related to values, emotions, and efficacy that were used for audience segmentation.

Together, the Level 1 and Level 2 data enable multilevel analyses of how message-level linguistic features interact with individual-level psychological characteristics to shape motivation for climate-friendly dietary behaviour.
DOI: 10.17632/93pfpppm6f.1
title: Linguistic Features of Climate Video Messages and Dietary Motivation

description: This dataset supports a study investigating how linguistic features embedded in climate-related short video messages influence climate-friendly dietary motivation among Chinese young adults. Participants (N = 711) were randomly assigned to view six short videos promoting sustainable eating and reported their motivational responses after each video.

The dataset is structured at two levels. Level 1 data consist of repeated observations at the video-viewing level, including post-viewing dietary motivation measures and linguistic characteristics of each video derived from the Linguistic Inquiry and Word Count (LIWC) dictionary, covering emotional, motivational, and cognitive word categories. Level 2 data include participant-level information, such as demographic variables (e.g., age, gender, education) and psychological measures related to values, emotions, and efficacy that were used for audience segmentation.

Together, the Level 1 and Level 2 data enable multilevel analyses of how message-level linguistic features interact with individual-level psychological characteristics to shape motivation for climate-friendly dietary behaviour.
DOI: 10.5281/zenodo.18375099
title: Received Signal Strength Measurements for Below-ground Potato Tuber Biomass Estimation in Outdoor Environments

description: This dataset contains received signal strength (RSS) data collected in outdoor environments for below-ground biomass estimation. Specifically, we construct an outdoor potato tuber planting scenario and perform preliminary experiments. In this outdoor scenario, we build two ridges to bury potato tubers, each with a length of 4 m. We select 18 potato tubers for data collection, with weights ranging from 101.3 g to 204.1 g. These tubers are evenly planted in the two ridges, with a 0.5 m spacing between adjacent tubers. Then, our testbed is deployed along each ridge to collect RSS data for each tuber. The testbed consists of 16 sensor nodes arranged in a square, with 13.5 cm between adjacent nodes. To facilitate mobility, these sensor nodes are mounted on a white rack measuring 54 cm × 54 cm. During data collection, each tuber is located at the center of the sensing area, and RSS data are recorded for one minute per tuber. More details on tuber weights and file naming conventions can be found in the 'ReadMe.txt' file. In addition, this dataset can be used as a supplement to the dataset at https://zenodo.org/records/15000852, which is collected in a greenhouse environment.
DOI: 10.5281/zenodo.18375100
title: Received Signal Strength Measurements for Below-ground Potato Tuber Biomass Estimation in Outdoor Environments

description: This dataset contains received signal strength (RSS) data collected in outdoor environments for below-ground biomass estimation. Specifically, we construct an outdoor potato tuber planting scenario and perform preliminary experiments. In this outdoor scenario, we build two ridges to bury potato tubers, each with a length of 4 m. We select 18 potato tubers for data collection, with weights ranging from 101.3 g to 204.1 g. These tubers are evenly planted in the two ridges, with a 0.5 m spacing between adjacent tubers. Then, our testbed is deployed along each ridge to collect RSS data for each tuber. The testbed consists of 16 sensor nodes arranged in a square, with 13.5 cm between adjacent nodes. To facilitate mobility, these sensor nodes are mounted on a white rack measuring 54 cm × 54 cm. During data collection, each tuber is located at the center of the sensing area, and RSS data are recorded for one minute per tuber. More details on tuber weights and file naming conventions can be found in the 'ReadMe.txt' file. In addition, this dataset can be used as a supplement to the dataset at https://zenodo.org/records/15000852, which is collected in a greenhouse environment.
DOI: 10.17632/ygky8cv8v8
title: Assessing Motivations, Challenges, and Restraints of the Honduran Nonprofit Sector in the Adoption of Crowdfunding

description: Abstract. Introduction. Crowdfunding strategies for the Non-Profit Sector in Honduras have been challenging for a long time. This research evaluates barriers, motivations, and responses from Honduran organizations, using Diffusion of Innovations Theory as a sensitizing analytical framework to interpret and evaluate nonprofit organization leaders’ perceptions of crowdfunding adoption. Methods. This study took a qualitative approach, developing a thematic analysis of in-depth interviews with 20 nonprofit organization leaders to identify cultural, contextual, and institutional factors that define and influence decision-making in crowdfunding strategies. Results. A total of eight big themes emerged from the thematic analysis that describe the motivations, barriers, and responses associated with the adoption, and non-adoption, of crowdfunding: 1) Sustainability, 2) International Donations, 3) Country’s context, 4) Institutional Weaknesses, 5) Emerging donating culture, 6) Outreach, 7) Fundraising policy; and 8) Communications. Conclusion. The study suggests that, unlike the global north, Honduras' decisions about adopting crowdfunding are not simply a matter of expanding or utilizing technology or innovation, but rather a series of cultural, political, and social factors that influence perceptions of trust and visibility, both internally and externally with donors. Several limitations should be considered when interpreting the findings of this study. Nevertheless, the study has practical implications as it highlights the need for more sensitive and adaptive approaches to crowdfunding adoption in Honduras compared to the realities in the global north.
DOI: 10.17632/ygky8cv8v8.1
title: Assessing Motivations, Challenges, and Restraints of the Honduran Nonprofit Sector in the Adoption of Crowdfunding

description: Abstract. Introduction. Crowdfunding strategies for the Non-Profit Sector in Honduras have been challenging for a long time. This research evaluates barriers, motivations, and responses from Honduran organizations, using Diffusion of Innovations Theory as a sensitizing analytical framework to interpret and evaluate nonprofit organization leaders’ perceptions of crowdfunding adoption. Methods. This study took a qualitative approach, developing a thematic analysis of in-depth interviews with 20 nonprofit organization leaders to identify cultural, contextual, and institutional factors that define and influence decision-making in crowdfunding strategies. Results. A total of eight big themes emerged from the thematic analysis that describe the motivations, barriers, and responses associated with the adoption, and non-adoption, of crowdfunding: 1) Sustainability, 2) International Donations, 3) Country’s context, 4) Institutional Weaknesses, 5) Emerging donating culture, 6) Outreach, 7) Fundraising policy; and 8) Communications. Conclusion. The study suggests that, unlike the global north, Honduras' decisions about adopting crowdfunding are not simply a matter of expanding or utilizing technology or innovation, but rather a series of cultural, political, and social factors that influence perceptions of trust and visibility, both internally and externally with donors. Several limitations should be considered when interpreting the findings of this study. Nevertheless, the study has practical implications as it highlights the need for more sensitive and adaptive approaches to crowdfunding adoption in Honduras compared to the realities in the global north.