cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.30414883
title: Supplementary Material for: Development and Feasibility Assessment of a Multi-Modal Digital Health Technology for Remote Monitoring of Symptoms in Myasthenia Gravis

description: Myasthenia gravis (MG) is a chronic autoimmune neuromuscular disease. Patients with MG are typically evaluated by neuromuscular experts through in-person neurologic examinations. These assessments are time-consuming, require significant disease expertise, and capture only a snapshot of disease. Given this need, we developed a multi-modal digital health technology (DHT) called BioDigit MG, for monitoring MG symptoms and objectively measuring disease severity. BioDigit MG includes tablet-guided speech and video-based assessments, electronic patient-reported outcomes relevant to MG, and a wearable sensor to measure physical activity and posture during activities of daily living. We assessed the feasibility and acceptability of BioDigit MG by conducting a clinical study with 20 participants with MG who used the DHT. During the study, a total of 219 speech tasks and 119 videos were collected by the DHT, achieving 100% reliability in data collection and transfer. To evaluate technology acceptance and usability, we conducted face-to-face interviews with the 20 MG patients and 5 expert clinicians. Participants found the DHT highly effective, easy to use, and well-suited to their needs. Efficient and reliable data transfer capabilities of BioDigit MG ensured that patient-generated data were promptly and securely delivered to healthcare providers. These feasibility findings demonstrate that BioDigit MG is capable of reliable multimodal data collection and is acceptable to both patients and clinicians, supporting its potential for use in future larger-scale validation studies.
DOI: 10.6084/m9.figshare.30414883.v1
title: Supplementary Material for: Development and Feasibility Assessment of a Multi-Modal Digital Health Technology for Remote Monitoring of Symptoms in Myasthenia Gravis

description: Myasthenia gravis (MG) is a chronic autoimmune neuromuscular disease. Patients with MG are typically evaluated by neuromuscular experts through in-person neurologic examinations. These assessments are time-consuming, require significant disease expertise, and capture only a snapshot of disease. Given this need, we developed a multi-modal digital health technology (DHT) called BioDigit MG, for monitoring MG symptoms and objectively measuring disease severity. BioDigit MG includes tablet-guided speech and video-based assessments, electronic patient-reported outcomes relevant to MG, and a wearable sensor to measure physical activity and posture during activities of daily living. We assessed the feasibility and acceptability of BioDigit MG by conducting a clinical study with 20 participants with MG who used the DHT. During the study, a total of 219 speech tasks and 119 videos were collected by the DHT, achieving 100% reliability in data collection and transfer. To evaluate technology acceptance and usability, we conducted face-to-face interviews with the 20 MG patients and 5 expert clinicians. Participants found the DHT highly effective, easy to use, and well-suited to their needs. Efficient and reliable data transfer capabilities of BioDigit MG ensured that patient-generated data were promptly and securely delivered to healthcare providers. These feasibility findings demonstrate that BioDigit MG is capable of reliable multimodal data collection and is acceptable to both patients and clinicians, supporting its potential for use in future larger-scale validation studies.
DOI: 10.6084/m9.figshare.30414886
title: Supplementary Material for: Use of Robotic-Like Articulated Instruments in Medical Thoracoscopy: A Case Series

description: Introduction: Medical thoracoscopy (MT) is a minimally invasive procedure primarily used for diagnosing pleural diseases. However, its therapeutic role, especially in complex pleural infections, is underexplored. Rising pleural disease incidence and the need for less invasive treatment options have spurred interest in enhancing MT’s capabilities. Disposable articulated wristed instruments, initially designed for laparoscopic surgery, offer improved dexterity and precision, potentially expanding MT’s therapeutic use. 
Case Series: We present three patients with complex pleural effusions managed with medical thoracoscopy (MT), utilizing articulated, robotic-like instruments (ArtiSential, LivsMed) under Monitored Anesthesia Care (MAC) at a tertiary care center:
 A 67-year-old man with a recurrent, loculated exudative effusion underwent dual-port thoracoscopy due to high suspicion of tuberculous pleurisy versus malignancy. The use of articulated instruments enabled precise adhesiolysis and effective drainage, which ultimately facilitated diagnosis and successful initiation of anti-tuberculosis treatment.
 A 64-year-old male with suspected malignant pleural effusion underwent single-port thoracoscopy. The use of an articulated dissector and an articulated monopolar spatula allowed for precise adhesiolysis, facilitating both diagnostic sampling and therapeutic intervention, including successful placement of a tunneled pleural catheter in a cleared pleural space
 A 64-year-old COPD patient with anaerobic empyema had dual-port thoracoscopy. Articulated tools allowed precise debridement and evacuation without the need for adjunct fibrinolytic therapy.
Conclusion: These cases demonstrate that articulated wristed instruments can enhance MT’s precision and reach in complex pleural spaces, overcoming limitations of traditional tools. Their use broadens therapeutic options for patients unsuitable for surgery and supports MT as a minimally invasive, effective intervention. Continued innovation and research are essential to validate benefits on clinical outcomes and healthcare utilization, ensuring MT remains a vital tool in managing pleural diseases
DOI: 10.6084/m9.figshare.30414886.v1
title: Supplementary Material for: Use of Robotic-Like Articulated Instruments in Medical Thoracoscopy: A Case Series

description: Introduction: Medical thoracoscopy (MT) is a minimally invasive procedure primarily used for diagnosing pleural diseases. However, its therapeutic role, especially in complex pleural infections, is underexplored. Rising pleural disease incidence and the need for less invasive treatment options have spurred interest in enhancing MT’s capabilities. Disposable articulated wristed instruments, initially designed for laparoscopic surgery, offer improved dexterity and precision, potentially expanding MT’s therapeutic use. 
Case Series: We present three patients with complex pleural effusions managed with medical thoracoscopy (MT), utilizing articulated, robotic-like instruments (ArtiSential, LivsMed) under Monitored Anesthesia Care (MAC) at a tertiary care center:
 A 67-year-old man with a recurrent, loculated exudative effusion underwent dual-port thoracoscopy due to high suspicion of tuberculous pleurisy versus malignancy. The use of articulated instruments enabled precise adhesiolysis and effective drainage, which ultimately facilitated diagnosis and successful initiation of anti-tuberculosis treatment.
 A 64-year-old male with suspected malignant pleural effusion underwent single-port thoracoscopy. The use of an articulated dissector and an articulated monopolar spatula allowed for precise adhesiolysis, facilitating both diagnostic sampling and therapeutic intervention, including successful placement of a tunneled pleural catheter in a cleared pleural space
 A 64-year-old COPD patient with anaerobic empyema had dual-port thoracoscopy. Articulated tools allowed precise debridement and evacuation without the need for adjunct fibrinolytic therapy.
Conclusion: These cases demonstrate that articulated wristed instruments can enhance MT’s precision and reach in complex pleural spaces, overcoming limitations of traditional tools. Their use broadens therapeutic options for patients unsuitable for surgery and supports MT as a minimally invasive, effective intervention. Continued innovation and research are essential to validate benefits on clinical outcomes and healthcare utilization, ensuring MT remains a vital tool in managing pleural diseases
DOI: 10.57841/casdc.0005799
title: 全国城镇精细化预报产品数据集
DOI: 10.6084/m9.figshare.30414889
title: Supplementary Material for: Transcriptomic Insights into Polyomavirus Nephropathy in Kidney Transplants: Evaluating the Utility of the B-HOT Panel

description: Background: Polyomavirus nephropathy (PyVN) is a significant complication following kidney transplantation, characterized by tubulointerstitial inflammation that mimics T cell-mediated rejection (TCMR). The Banff Human Organ Transplant (B-HOT) panel, a transcriptomic analysis tool comprising 770 genes, has been developed to facilitate the diagnosis of allograft rejection. However, its utility in distinguishing PyVN from TCMR remains unclear.
Objective: This study aimed to evaluate the biochemical characteristics of PyVN and TCMR using the B-HOT panel, investigate changes after PyVN treatment, and assess the panel's diagnostic utility.
Methods: Formalin-fixed paraffin-embedded (FFPE) tissue samples from 11 PyVN patients were analyzed at diagnosis and follow-up using the B-HOT panel. Public datasets were compared to identify differentially expressed genes (DEG) and activated pathways. Prognostic factors were explored based on viral clearance and renal function outcomes.
Results: BK VP1 gene expression was significantly elevated in PyVN cases, aiding diagnosis. While tissue homeostasis pathways were upregulated in PyVN compared to TCMR in original data, no specific pathways were identified in public datasets. Successful viral clearance correlated with enhanced T cell checkpoint signaling at diagnosis, suggesting its role in immune-mediated viral elimination.
Conclusion: The B-HOT panel provides limited utility for diagnosing PyVN beyond viral gene quantification. However, T cell checkpoint signaling may serve as a prognostic marker for viral clearance and renal function preservation in PyVN cases. Further studies are needed to refine molecular diagnostics for PyVN and improve transplant outcomes.
DOI: 10.6084/m9.figshare.30414889.v1
title: Supplementary Material for: Transcriptomic Insights into Polyomavirus Nephropathy in Kidney Transplants: Evaluating the Utility of the B-HOT Panel

description: Background: Polyomavirus nephropathy (PyVN) is a significant complication following kidney transplantation, characterized by tubulointerstitial inflammation that mimics T cell-mediated rejection (TCMR). The Banff Human Organ Transplant (B-HOT) panel, a transcriptomic analysis tool comprising 770 genes, has been developed to facilitate the diagnosis of allograft rejection. However, its utility in distinguishing PyVN from TCMR remains unclear.
Objective: This study aimed to evaluate the biochemical characteristics of PyVN and TCMR using the B-HOT panel, investigate changes after PyVN treatment, and assess the panel's diagnostic utility.
Methods: Formalin-fixed paraffin-embedded (FFPE) tissue samples from 11 PyVN patients were analyzed at diagnosis and follow-up using the B-HOT panel. Public datasets were compared to identify differentially expressed genes (DEG) and activated pathways. Prognostic factors were explored based on viral clearance and renal function outcomes.
Results: BK VP1 gene expression was significantly elevated in PyVN cases, aiding diagnosis. While tissue homeostasis pathways were upregulated in PyVN compared to TCMR in original data, no specific pathways were identified in public datasets. Successful viral clearance correlated with enhanced T cell checkpoint signaling at diagnosis, suggesting its role in immune-mediated viral elimination.
Conclusion: The B-HOT panel provides limited utility for diagnosing PyVN beyond viral gene quantification. However, T cell checkpoint signaling may serve as a prognostic marker for viral clearance and renal function preservation in PyVN cases. Further studies are needed to refine molecular diagnostics for PyVN and improve transplant outcomes.
DOI: 10.6084/m9.figshare.30414892
title: Supplementary Material for: Adverse effects and functional outcome after salvage lymph node dissection in prostate cancer

description: Introduction: 
To generate a standardized assessment of postoperative complications and functional results in patients undergoing salvage lymph node dissection (sLND) in a multi-modal setting with prior primary therapy and possibly multiple courses of radiation due to nodal-recurrent prostate cancer.
Patients and methods: 
This study included 173 patients that were performed between 2005 and 2019. Postoperative complications were reported according to Clavien-Dindo-Classification (CDC). Health-related quality of life (QoL) was assessed prospectively using a validated questionnaire (EORTC QLQ-C30). Postoperative urinary incontinence was quantified with the assessment of pad usage and the ICIQ-SF questionnaire.
Results: 
The any-grade complication complication rate after sLND was 67% (n=115 patients). 24% of patients (n=42) had severe postoperative complications (CDC Grade ≥IIIa). No Grade V complications were reported. The number of lymph nodes removed was higher in patients with any-grade complications (median 32 versus 25, p=0.03), while the number of lymph node metastases was higher in patients with severe complications (median 7 versus 3, p=0.03). However, no clinical parameter was independently associated with complications. 56% of patients didn’t require any pads postoperatively. Median postoperative ICIQ-SF score was 5, and was higher in patients with any prior radiation (median 6 versus 0, p=0.03). Radical prostatectomy as primary therapy (p=0.01) and any prior radiation (p=0.01) were independent predictors of any incontinence. Patients’ QoL was rated as moderate, with an impairment in QoL in 39% of the follow-up cohort.
Conclusion:
SLND is a treatment option in selected patients with nodal-recurrent prostate cancer with considerable complication rates and possible functional impairments that need to be discussed with the patient when balancing the indication for this metastasis-directed treatment option.
DOI: 10.6084/m9.figshare.30414892.v1
title: Supplementary Material for: Adverse effects and functional outcome after salvage lymph node dissection in prostate cancer

description: Introduction: 
To generate a standardized assessment of postoperative complications and functional results in patients undergoing salvage lymph node dissection (sLND) in a multi-modal setting with prior primary therapy and possibly multiple courses of radiation due to nodal-recurrent prostate cancer.
Patients and methods: 
This study included 173 patients that were performed between 2005 and 2019. Postoperative complications were reported according to Clavien-Dindo-Classification (CDC). Health-related quality of life (QoL) was assessed prospectively using a validated questionnaire (EORTC QLQ-C30). Postoperative urinary incontinence was quantified with the assessment of pad usage and the ICIQ-SF questionnaire.
Results: 
The any-grade complication complication rate after sLND was 67% (n=115 patients). 24% of patients (n=42) had severe postoperative complications (CDC Grade ≥IIIa). No Grade V complications were reported. The number of lymph nodes removed was higher in patients with any-grade complications (median 32 versus 25, p=0.03), while the number of lymph node metastases was higher in patients with severe complications (median 7 versus 3, p=0.03). However, no clinical parameter was independently associated with complications. 56% of patients didn’t require any pads postoperatively. Median postoperative ICIQ-SF score was 5, and was higher in patients with any prior radiation (median 6 versus 0, p=0.03). Radical prostatectomy as primary therapy (p=0.01) and any prior radiation (p=0.01) were independent predictors of any incontinence. Patients’ QoL was rated as moderate, with an impairment in QoL in 39% of the follow-up cohort.
Conclusion:
SLND is a treatment option in selected patients with nodal-recurrent prostate cancer with considerable complication rates and possible functional impairments that need to be discussed with the patient when balancing the indication for this metastasis-directed treatment option.
DOI: 10.6084/m9.figshare.30414895
title: Supplementary Material for: “An amazing transformation!” The lived experiences of elexacaftor/tezacaftor/ivacaftor in adults with CF

description: Introduction: Cystic fibrosis (CF) is associated with a high respiratory symptom and treatment burden. Elexacaftor/tezacaftor/ivacaftor (ETI) provides substantial improvements in physiological outcomes such as respiratory function and sweat chloride. This study sought to comprehensively examine an area of limited research in this field: the lived experiences of adults with CF after ETI initiation. 
Methods: Adults with CF completed semi-structured interviews at least six weeks following the initiation of ETI. Participants shared their experiences regarding respiratory-related symptoms, airway clearance routines, and their capacity to participate in physical activity. Interviews were audio-recorded, transcribed verbatim and analysed using the Framework Method.
Results: Seventeen participants completed interviews (FEV1 range before ETI initiation 31 to 87 %pred). All participants reported improvements in respiratory-related symptoms including cough, sputum expectoration, dyspnoea, and chest tightness. As a result, there was a reduction in participants airway clearance treatment burden and improvements in their capacity to participate in physical activity, health-related quality of life (HRQoL) and outlook for the future. The overall theme highlighted in this study was that ETI had “completely changed everything” and they can now do “everything I wasn’t able to do before” due to the reductions in symptom and treatment burden.
Conclusion: Participants consistently described their experiences with ETI in positive terms. The results of this study confirm that ETI is in fact perceived to be a “miracle drug” and has had a transformative effect on the everyday lives of adults with CF through improved HRQoL and overall wellbeing, which led to positive views regarding their future with CF and ongoing medical care.
DOI: 10.6084/m9.figshare.30414895.v1
title: Supplementary Material for: “An amazing transformation!” The lived experiences of elexacaftor/tezacaftor/ivacaftor in adults with CF

description: Introduction: Cystic fibrosis (CF) is associated with a high respiratory symptom and treatment burden. Elexacaftor/tezacaftor/ivacaftor (ETI) provides substantial improvements in physiological outcomes such as respiratory function and sweat chloride. This study sought to comprehensively examine an area of limited research in this field: the lived experiences of adults with CF after ETI initiation. 
Methods: Adults with CF completed semi-structured interviews at least six weeks following the initiation of ETI. Participants shared their experiences regarding respiratory-related symptoms, airway clearance routines, and their capacity to participate in physical activity. Interviews were audio-recorded, transcribed verbatim and analysed using the Framework Method.
Results: Seventeen participants completed interviews (FEV1 range before ETI initiation 31 to 87 %pred). All participants reported improvements in respiratory-related symptoms including cough, sputum expectoration, dyspnoea, and chest tightness. As a result, there was a reduction in participants airway clearance treatment burden and improvements in their capacity to participate in physical activity, health-related quality of life (HRQoL) and outlook for the future. The overall theme highlighted in this study was that ETI had “completely changed everything” and they can now do “everything I wasn’t able to do before” due to the reductions in symptom and treatment burden.
Conclusion: Participants consistently described their experiences with ETI in positive terms. The results of this study confirm that ETI is in fact perceived to be a “miracle drug” and has had a transformative effect on the everyday lives of adults with CF through improved HRQoL and overall wellbeing, which led to positive views regarding their future with CF and ongoing medical care.
DOI: 10.57841/casdc.0005801
title: 中国气象辐射逐小时数据集
DOI: 10.15468/dl.22caqk
title: Occurrence Download

description: A dataset containing 17084 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Cornus drummondii"
 ]
}

 The dataset includes 17084 records from 176 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0048950-251009101135966/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.8zhgqg
title: Occurrence Download

description: A dataset containing 129808 species occurrences available in GBIF matching the query:
{
 "and" : [
 {
 "and" : [
 "HasGeospatialIssue is false",
 "HasCoordinate is true",
 "OccurrenceStatus is Present",
 {
 "not" : {
 "BasisOfRecord" : [
 "is one of (Fossil, Living Specimen)"
 ]
 }
 }
 ]
 },
 "TaxonKey is one of (Allium orestis, Allium lazikkiyense, Allium maghrebinum, Astragalus adunciformis, Astragalus cretaceus, Astragalus cymbibracteatus, Astragalus czorochensis, Astragalus scabrifolius, Astragalus trachytrichus, Astragalus transjordanicus, Astragalus turcicus, Allium aybukeae, Crepis bupleurifolia, Astragalus ertterae, Astragalus kirchhoffiae, Arceuthobium littorum, Serapias alberti, Juncus anatolicus, Juncus capillaris, Juncus chlorocephalus, Allium galileum, Aristida behriana, Aristida meridionalis, Pattalias palmeri, Allium pervariensis, Microdon orbicularis, Astragalus mugliensis, Hedyosmum mexicanum, Astragalus fabaceus, Astragalus iranicus, Astragalus mareoticus, Allium polyanthum, Allium rupestre, Allium suaveolens, Juncus laccatus, Juncus macrandrus, Juncus microcephalus, Juncus ochrocoleus, Trifolium meduseum, Trifolium setiferum, Astragalus layneae, Astragalus prusianus, Astragalus pungens, Berberis repens, Juncus valbrayi, Allium albanicum, Crepis athoa, Crepis foetida, Crepis lacera, Astragalus uraniolimneus, Trifolium sonorense, Haplopappus glutinosus, Ferulago platycarpa, Ferulago sandrasica, Ferulago stellata, Ferulago syriaca, Aldama dentata, Allium corsicum, Allium djimilense, Allium dumetorum, Allium longanum, Allium orientale, Allium parciflorum, Gethyllis fimbriatula, Gethyllis lata, Allium tingitanum, Leucadendron cadens, Leucadendron comosum, Petalonyx nitidus, Arceuthobium campylopodum, Astragalus cinereus, Astragalus demirizii, Astragalus marivanensis, Astragalus rhodochrous, Astragalus sericophyllus, Astragalus sosnowskyi, Astragalus tawilicus, Elymus clivorum, Crepis macropus, Astragalus antalyensis, Astragalus pachypus, Astragalus tauricola, Astragalus tricarinatus, Ferulago aucheri, Ferulago blancheana, Ferulago macrosciadea, Juncus dubius, Trifolium bocconei, Leucadendron macowanii, Leucadendron galpinii, Levenhookia dubia, Astragalus funereus, Astragalus aybarsii, Lasthenia kunthii, Disperis macowanii, Allium platycaule, Allium proponticum, Allium pseudoampeloprasum, Allium schoenoprasum, Allium serra)",
 "Year is greater than or equal to 1950"
 ]
}

 The dataset includes 129808 records from 1397 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0048937-251009101135966/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.ssuwaw
title: Occurrence Download

description: A dataset containing 387 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Pseudocentrotus depressus (A.Agassiz, 1864)"
 ]
}

 The dataset includes 387 records from 29 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0005429-250227182430271/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.