cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.16437768.v1
title: Supplementary Material for: Physical Activity and Long-Term Mortality Risk in Older Adults with and without Cardiovascular Disease: A Nationwide Cohort Study

description: <b><i>Aims:</i></b> To evaluate the association between physical activity (PA) levels and mortality among older adults, to determine whether it differs according to cardiovascular disease (CVD) status, and to assess the optimal weekly duration of PA associated with subsequent survival. <b><i>Methods:</i></b> Participants (<i>n</i> = 1,799) were drawn from a national survey conducted from 2005 to 2006, constituting Israeli adults aged ≥65 years. Sociodemographic, clinical, behavioral, and psychosocial data were collected via interview at study entry. Based on a detailed PA questionnaire and according to published guidelines, participants were classified as sufficiently active, insufficiently active, and inactive. CVD status was self-reported. Mortality data (last follow-up, December 2016) were obtained from the Israeli Ministry of Health. Using Cox models, inverse probability weighted hazard ratios (HRs) for mortality, based on propensity score, were estimated for PA categories. <b><i>Results:</i></b> Among the participants at baseline (mean age, 74.6 years), 559 (31.1%) were sufficiently active, 506 (28.1%) were insufficiently active, and 734 (40.8%) were inactive. During follow-up (mean, 9.0 years), 684 participants (38.0%) died. PA was inversely associated with mortality, with propensity score-adjusted HRs (95% confidence intervals) of 0.84 (0.71–1.01) in insufficiently and 0.73 (0.61–0.88) in sufficiently active participants (<i>p</i><sub>trend</sub> &lt; 0.001). No PA-by-CVD interaction was detected on multiplicative scale (<i>p</i> = 0.36) or additive scale (<i>p</i> = 0.58). A monotonic survival benefit was observed until ∼150 min of PA per week, beyond which no further gain was apparent. <b><i>Conclusions:</i></b> In a nationwide cohort of older adults, nearly 70% did not meet the guideline for PA. PA engagement was inversely associated with long-term mortality risk, similarly in individuals with and without CVD. A maximum survival advantage was achieved at around 150 min of exercise per week.
DOI: 10.6084/m9.figshare.5695564.v1
title: Benchmark WGBS data (sample 2 in 3 versus 3 sample comparison)

description: Benchmark WGBS data (sample 2 in 3 versus 3 sample comparison)<br><br>This file contains simulated benchmark WGBS data for 1 sample from a 3 vs 3 comparison saved as a `.txt.gz` (compressed text file). The tab-delimited text file contains four columns: chromosome, position, number of methylated reads, and total number of reads coverage.<br><br>This benchmark data was created to mimic the properties of real WGBS data in order to evaluate the method dmrseq (described in the preprint at https://doi.org/10.1101/183210). This was done by splitting a set of biological replicates (controls) into two artificial groups and adding methylation differences to randomly selected regions. Differences are added between the first half of samples and the second half of samples. More methodological details and a script to reproduce the generation of this data file is available at the companion repository: https://github.com/kdkorthauer/dmrseqPaper.
DOI: 10.6084/m9.figshare.20222891.v1
title: Spermidine overrides INSR (insulin receptor)-IGF1R (insulin-like growth factor 1 receptor)-mediated inhibition of autophagy in the aging heart

description: Although attenuated IGF1R (insulin-like growth factor 1 receptor) signaling has long been viewed to promote longevity in model organisms, adverse effects on the heart have been the subject of major concern. We observed that IGF1R is overexpressed in cardiac tissues from patients with end-stage non-ischemic heart failure, coupled to the activation of the IGF1R downstream effector AKT/protein kinase B and inhibition of ULK1 (unc-51 like autophagy activating kinase 1). Transgenic overexpression of human IGF1R in cardiomyocytes from mice initially induces physiological cardiac hypertrophy and superior function, but later in life confers a negative impact on cardiac health, causing macroautophagy/autophagy inhibition as well as impaired oxidative phosphorylation, thus reducing life expectancy. Treatment with the autophagy inducer and caloric restriction mimetic spermidine ameliorates most of these IGF1R-induced cardiotoxic effects in vivo. Moreover, inhibition of IGF1R signaling by means of a dominant-negative phosphoinositide 3-kinase (PI3K) mutant induces cardioprotective autophagy, restores myocardial bioenergetics and improves late-life survival. Hence, our results demonstrate that IGF1R exerts a dual biphasic impact on cardiac health, and that autophagy mediates the late-life geroprotective effects of IGF1R inhibition in the heart.
DOI: 10.6084/m9.figshare.24926301.v1
title: Determinants of Oral Squamous Cell Carcinoma.dta

description: This study provides baseline data that may inform guidelines for clinicians on the screening and management of OSCC and may help to identify the determinants of OSCC in the current setting and raise awareness to improve individualized patient care and management among those at risk of developing OSCC.
DOI: 10.15131/shef.data.19299539.v1
title: Human-Robot Video Data from a Manufacturing Factory

description: This repository provides videos collected when an operator or several operators are interacting with an UR5 robot in a manufacturing factory. This data repository could be used for object detection, classification and segmentation tasks in videos.
DOI: 10.6084/m9.figshare.1284681.v1
title: A Novel Strategy for the Expansion of Peripheral Blood Stem Cells in Autologous

description: Stem Cells are now the favorite cells used for cell therapy in many disease conditions including spinal cord injury, stroke, Alzheimer’s disease, Parkinson’s disease, and several other problems. They are also a standard of care in the treatment of some selected patients with cancer after high-dose chemotherapy (HDC). This is because of their potential to repair and regenerate damaged cells, tissues and organ. The bottle neck to the clinical application of Peripheral Blood Stem Cells (PBSCs) has been the low level of the concentration recovered after apheresis that is mostly insufficient to produce therapeutic efficacy. Ex vivo expansion of PBSC is a logical step to overcome such problem, but current efforts in this direction are still inefficient. The purpose of this thesis is to demonstrate the efficacy of scaling up of PBSC in manipulated autologous serum coupled with the synergistic action of hematopoietic growth factors (HGFs) in the presence of stromal cell derived factor. We derived PDGF from autologous serum using cellaid protocol, then supplement the serum with interleukin 3 (IL-3), interleukin 6 (IL-6), stem cell factor (SCF), granulocytes colony stimulating factor (G-CSF), megakaryocytes growth and differentiation factor (MGDF) and stromal cell derived factor (SCDF) Our result indicates that bench scale expansion of PBSC is possible in autologous serum. To translate this success into the clinic, the cells need to be expanded in a large scale. Here we describe a proposed design for automation ex vivo that will allow our expansion protocol to be translated into machine/device manipulation to allow for routine clinical application that favors good manufacturing practice
DOI: 10.6084/m9.figshare.28029359.v1
title: Base de datos - ANALISIS BIBLIOMÉTRICO EN SCOPUS RESPECTO AL USO DE LA INTELIGENCIA ARTIFICIAL EN MEDICINA OCUPACIONAL

description: La salud ocupacional es un campo crucial que busca garantizar el bienestar físico, mental y social de los trabajadores en su entorno laboral. La inteligencia artificial (IA) ha surgido como una herramienta poderosa para transformar este campo, ofreciendo nuevas posibilidades para prevenir riesgos, mejorar la salud y promover el bienestar en el trabajo. Se tiene como objetivo realizar el análisis bibliométrico de publicaciones científicas registradas en Scopus sobre inteligencia artificial aplicada a la medicina ocupacional hasta el año 2023.
DOI: 10.6084/m9.figshare.7286282.v1
title: Data

description: Data for a study by Kao-Wei Chua and Isabel Gauthier, submitted to JEP:G in 2018
DOI: 10.6084/m9.figshare.25982530.v1
title: Supplementary Material for: Exploring the Association Between Depression, Suicidality, and Serum BDNF, FAM19A5, TAS, TOS, OSI, and Cytokine Levels: A Case-Control Study of Drug-Naïve Adolescents with First-Episode Major Depressive Disorder

description: Introduction: Considering the importance of neuroinflammation and neurodegeneration in the pathophysiology of major depressive disorder (MDD), peripheral blood biomarkers are promising for the prediction of diagnosis and treatment outcomes. We aim to elucidate the neuroinflammatory pathophysiology of depression by evaluating serum levels of FAM19A5 as a new biomarker of inflammatory activation, proinflammatory cytokines, brain-derived neurotrophic factor (BDNF) and oxidative stress parameters. 
Methods: Adolescents diagnosed with first-episode drug-naive MDD (n=35) were compared neurobiologically healthy control group (n=33). Serum FAM19A5 levels, cytokine levels, BDNF and oxidative stress parameters were evaluated using ELISA method. All participants were assessed with the level 2 depression severity scale, sleep disturbance scale, somatic symptom scale.
Results: BDNF levels were significantly higher in the patient group compared to the control group. While BDNF showed a positive correlation with all scale scores; BDNF was significantly higher in the suicide risk groups than control group. IL1β levels displayed a negative correlation with the severity of sleep disturbances.
Conclusions: In adolescents with MDD, inflammatory and oxidative stress markers were not raised in peripheral blood, unlike in adults. However, BDNF levels, which typically decrease in neurodegenerative conditions, were higher in those with MDD.
DOI: 10.25573/serc.25722627.v1
title: Extended Data Table for Biodiversity effects in the wild are common and as strong as key drivers of productivity

description: Dataset that accompanies Duffy, James Emmett, Godwin, Casey M., and Cardinale, Bradley J. 2017. "Biodiversity effects in the wild are common and as strong as key drivers of productivity." <i>Nature</i> (549): 261‚Äì264. https://doi.org/10.1038/nature23886
DOI: 10.6084/m9.figshare.3527774.v1
title: Appendix A. A figure showing results of the simulation study.

description: A figure showing results of the simulation study.
DOI: 10.6084/m9.figshare.6949064.v1
title: Supplementary Material for: Detection of Antibiotic Resistance Determinants and Their Transmissibility among Clinically Isolated Carbapenem-Resistant <b><i>Escherichia coli</i></b> from South India

description: <b><i>Objectives:</i></b> The aim of this study was to analyze the prevalence of the CTX-M, TEM, SHV, VIM, NDM, and OXA genes in carbapenemase-producing <i>Escherichia coli</i> and their transmissibility at a tertiary care hospital in south India. <b><i>Materials and Methods:</i></b> Twenty-one carbapenem-resistant <i>E. coli</i> (carbapenem-resistant Enterobacteriaceae; CRE) were collected from the Sri Sathya Sai Institute of Higher Medical Sciences (Puttaparthi India). Resistance to antibiotics was analyzed by Vitek-2, and the identity of the isolates was confirmed by 16S rDNA sequencing. RAPD and enterobacterial repetitive intergenic consensus (ERIC)-PCR were performed for molecular typing. Metallo-β-lactamase production was confirmed by a double disc synergy test. The presence of the extended-spectrum β-lactamases CTX-M, TEM, and SHV and of the carbapenemases NDM, VIM, and OXA was determined by PCR. Carbapenemase variants were further confirmed by sequencing. The transmissibility of the genes was tested by conjugation. <b><i>Results:</i></b> Twelve of the 21 (57%) carbapenem-resistant <i>E. coli</i> isolates were community acquired, indicating the spread of CRE in environmental samples. TEM and NDM-5 were found to be the major β-lactamases produced by the pathogens. OXA-181 was found in 5 of the isolates. All 21 isolates were found to harbor more than one of the tested β-lactamases, and all of the isolates were found to have the capacity to participate in conjugation; 15 of the transconjugants were found to have acquired the tested β-lactamases, substantiating their ability to be transferred to other strains of bacteria. <b><i>Conclusion:</i></b> Monitoring of community-acquired carbapenem-resistant bacteria is very important as the association of resistance determinants with mobile genetic elements would present a serious clinical challenge.
DOI: 10.6084/m9.figshare.17707220.v1
title: EEG Dataset for RSVP and P300 Speller Brain-Computer Interfaces

description: EEG dataset for subject 01
DOI: 10.6084/m9.figshare.28466906.v1
title: Predicting Olympic Medal Tally: An XGBoost Model for Forecasting and Investment in Sports Development

description: We developed an XGBoost prediction model based on historical medal data, host country factors, participant numbers, and other non-economic variables. The model successfully forecasted Olympic medal totals from 1960 to 2024, achieving an outstanding performance with an NRMSE of ~0.05 and R² of ~0.9, outperforming Random Forest (RF) and Support Vector Machine (SVM) models. Using this model, we predicted the 2028 Olympic medal table and optimized it for countries that have never won medals, achieving an NRMSE of 0.0589 by incorporating the medal share of key nations. Our model also suggests a high probability (0.2655, odds: 2.77) that three countries will secure their first Olympic medal in 2028. Furthermore, we analyzed the "Great Coach Effect," identifying it as the most influential factor in medal success. Based on this, we highlighted three promising coaching investment opportunities. This model can also be utilized for calculating Olympic medal odds and guiding future investments in sports development.
DOI: 10.6084/m9.figshare.9751841.v1
title: Supplementary Material for: Aneurysm Architecture: First in vivo Imaging of Human Cerebral Aneurysms with Extravascular Optical Coherence Tomography

description: <b><i>Objective:</i></b> The present study was conducted to explore the value of 3-dimensional microscope integrated extravascular optical coherence tomography (OCT) as the first suitable intraoperative imaging modality of cerebral aneurysm (CA) and parent vessel wall morphology. <b><i>Methods:</i></b> Incidental CAs (<i>n</i> = 16) of the anterior circulation with indication for microsurgical clipping were scanned. <b><i>Results:</i></b> Analysis revealed that intraoperative OCT achieved to delineate the microstructural composition of the parent vessel in all cases and the CA wall in 68.8%. Clinical relevant characteristics such as thickness, calcification, residual tunica media, and atherosclerotic plaque of CA wall could be demonstrated with high image quality approaching the spatial resolution of histopathology. <b><i>Conclusion:</i></b> Our findings demonstrate that intraoperative OCT may hold promise as an additional imaging tool during neurovascular procedures.
DOI: 10.6084/m9.figshare.16800925.v1
title: Raw data for DeepImageTranslator V2

description: Raw data for "DeepImageTranslator V2: analysis of multimodal medical images using semantic segmentation maps generated through deep learning"
DOI: 10.6084/m9.figshare.14798346.v1
title: CNKI_118

description: This text file, exported from CNKI, has 118 selected translation technology teaching research papers.
DOI: 10.6084/m9.figshare.27029080.v1
title: Supplementary Material for: Bibliometric insights into research hotspots and trends in obesity and asthma from 2013 to 2023

description: Introduction: Obesity and asthma are closely linked, but the current state of research on this topic and future research directions have yet to be comprehensively explored. This study aims to provide an up-to-date overview of the research landscape in the field of obesity and asthma.
Methods: A bibliometric analysis was conducted using the Web of Science Core Collection database to identify papers published on obesity and asthma between 2013 and 2023. VOSviewer software was utilized for statistical analysis and visualization of collaborative networks, research trends, literature sources, citation analysis, co-citation analysis, and keyword analysis.
Results: A total of 3406 records from 1010 journals authored by 17347 researchers affiliated with 4573 institutes across 117 countries and regions were retrieved. The number of publications and citations increased annually. The United States and China contributed the majority of records. Major nodes in the collaboration network map included Harvard Medical School, Johns Hopkins University, University of Newcastle, Karolinska Institution, University of Toronto, and Seoul National University. Prolific authors included Anne E. Dixon, Erick Forno, Lisa G. Wood, Deepa Rastogi, and Fernando Holguin. Research trends and hotspots focused on metabolism studies, Mendelian randomization, gut microbiome, inflammation response, gene, biomarker research, and comorbidities were identified as potential future research frontiers.
Conclusion: This study provides a comprehensive overview of the current research status and trends in the field of obesity and asthma. Our findings highlight the importance of understanding collaboration patterns, research hotspots, and emerging frontiers to guide future research in this area.
DOI: 10.6084/m9.figshare.7991315.v1
title: soil quality

description: soil quality
DOI: 10.25403/upresearchdata.28535291.v1
title: The role of trade unions in green transitions from a power resources approach in the automotive industry

description: Data from this research was collected from 10 participants. It includes 10 consent forms, 10 interview transcripts, and 1 thematic analysis sheet, which was the method of data collection. The study explored efforts between trade unions and the automotive industry from a different lens, that is, by focusing on the role of automotive trade unions in the green transition, more particularly what trade unions are doing to become green within the automotive industry. Research design, approach, and method: A qualitative study was conducted, where a non-probability purposive sample was selected. The study consisted of 10 participants, who ranged from various levels within trade unions and the automotive industry. Data collection took place through semi-structured interviews with the consent of participants, and data was analysed according to thematic analysis.
DOI: 10.6084/m9.figshare.20424951.v1
title: Simulation: PreCracked Plate

description: The results are calculated with the FEM code FEAP 8.6 and an electro-mechanical phase-field element. <br> The result files (*.vtu) are for the Visualization Toolkit library (VTK, https://vtk.org/). The grafical frontend ParaView (https://www.paraview.org/) is used for visualisation and further data processing. <br> The data contain a ParaView state file (*.pvsm) and the field data along a path (*.csv), which are used for Fig. 10b. <br>
DOI: 10.6084/m9.figshare.23276999.v1
title: A Visible-Light-Driven Molecular Motor Based on Barbituric Acid

description: cartesian coordinates
DOI: 10.6084/m9.figshare.23266643.v1
title: <strong>Pisos bioclimáticos para la Cuenca Mediterránea como capas SIG de acceso abierto</strong>

description: Conjunto de datos asociado al artículo "<strong>Pisos bioclimáticos para la Cuenca Mediterránea como capas SIG de acceso abierto"</strong>
DOI: 10.6084/m9.figshare.24784164.v1
title: hbrc R package test data files

description: These test datasets are for use with the hbrc R package available here. The datasets correspond to a small region of the Hawke's Bay Region in Aotearoa New Zealand. They are used within the R package documentation to explain some of the capabilities.The test datasets were provided by Jan Schindler. The methods for preparing these data were developed with support from the MBIE Catalyst: Strategic Fund through the programme “Bridging the gap between remote sensing and tree modelling” Contract C09X1923.The work was supported by: the Strategic Science Investment Funding for Crown Research Institutes from the New Zealand Ministry of Business, Innovation and Employment’s Science and Innovation Group. This work was also supported by the Environmental Science section of Hawke’s Bay Regional Council via the LiDAR tools partnership project Contract Number HBRC-22-716.
DOI: 10.6084/m9.figshare.19836151.v1
title: Profile-HMMs

description: profile-hmms.tar.gz contains the profile hidden Markov models used in this work. cld.hmm - All Cld proteins cld1.hmm - Lineage 1 Cld cld2.hmm - Lineage 2 Cld PF00174.hmm - Pfam 00174 PF00384.hmm - Pfam 00384 PF00384_PCRA.hmm - A Pfam 00384 subfamily with reductase acitivity
DOI: 10.6084/m9.figshare.20763790.v1
title: Aktas_Prostatitis_Youtube.xlsx

description: Datasheet of the manuscript entitled "YouTube™ as a source of information on prostatitis: A quality and reliability analysis".
DOI: 10.6084/m9.figshare.5696218.v1
title: Evaluation of phenolic compounds and lipid-lowering effect of Morus nigra leaves extract

description: ABSTRACT Morus nigra L. (Moraceae) is a tree known as black mulberry and the leaves are used in folk medicine in the treatment of diabetes, high cholesterol and menopause symptoms. The aim of this study was to evaluate the M. nigra leaves phytochemical profile in different extractions and the hypolipidemic effect of the infusion comparing to the fenofibrate. Morus nigra infusion (MN) showed higher amounts of phenolics and flavonoids (83.85 mg/g and 79.96 µg/g, respectively), as well as antioxidant activity (83.85%) than decoction or hydromethanolic extracts. Although, decoction showed the best result for ascorbic acid (4.35 mg/100 g) than hydromethanolic or infusion (2.51 or 2.13 mg/100 g, respectively). The phenolic acids gallic, chlorogenic and caffeic and the flavonoids quercetin, rutin and catechin were found in the M. nigra extracts. Hyperlipidemic rats treated with 100, 200 or 400 mg/kg of MN decreased serum cholesterol, triglycerides and normalized lipoproteins. Furthermore, MN inhibited lipid peroxidation in liver, kidney and brain of hyperlipidemic rats. This study provides evidence that M. nigra leaves extracts are rich in polyphenols, mainly chlorogenic acid, which normalized hyperlipidemic disturbance. The results suggest a potential therapeutic effect of the M. nigra leaves infusion on dislipidemic condition and related oxidative stress.
DOI: 10.6084/m9.figshare.5650126.v1
title: Two phase flow through rough fractures

description: The simulation results are from solving the two-phase flow through normally-distributed rough fractures with a broad range of roughness (0.1-0.4) and correlation length (0.001-0.1m) of aperture field; the total fracture length L=0.1m. Each given roughness and correlation length has its own sub-folder with 100 realizations. Moreover, we conducted two phase flow simulations with increasing pressure gradient (as denoted by P_nw in Pascal).
DOI: 10.17632/t7tms7c62x.1
title: Accessory mineral isotope compositions constrain on anatexis and magma extraction in the deep crust and their implications for granite genesis

description: This is the supplementary materials for the article entitled "Accessory mineral isotope compositions constrain on anatexis and magma extraction in the deep crust and their implications for granite genesis". It includes two files. Supplementary Material 1: Tables S1-S8; Supplementary Material 2: Standard values.
DOI: 10.6084/m9.figshare.22188103.v3
title: Solar steam-driven membrane filtration for high flux water purification

description: Source Data Supplementary Figures
DOI: 10.6084/m9.figshare.21078340.v1
title: Table 1 - Outcomes.docx

description: Mental Health of Sports Coaches: A Systematic Review