cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.7942139
title: MICROBIOREACTORS AS ENGINEERING TOOLS FOR BIOPROCESS DEVELOPMENT

description: ABSTRACT Within the engineering and development of industrial bioprocesses, microbioreactors are microfluidic tools able to provide high-throughput screening tests in a fast and cheap manner by using small amounts of reagents. In addition, such tools are versatile and may allow a better controllability of parameters when compared to conventional bench-scale reactors. Consequentially, this technology has been gaining attention from the scientific community over the past years. In such scenario, this work provides a review study of the microbioreactor technology, outlining the origin, main concepts and principles of such technology, aiming to elucidate general questions that may emerge when studying such an approach. Past and current approaches are discussed aiming at drawing a comparative picture about such technology regarding future developments.
DOI: 10.6084/m9.figshare.7942142
title: VES-13 and WHOQOL-bref cutoff points to detect quality of life in older adults in primary health care

description: ABSTRACT OBJECTIVE: To determine Vulnerable Elders Survey (VES-13) and WHOQOL-bref cutoff points to detect poor quality of life (QoL) in older individuals. METHODS: This is a cross-sectional study, performed in all primary health care units in Samambaia, DF, Brazil. The data were collected from August 2016 to May 2017. The sample size of 466 older individuals treated in primary health care was obtained considering a 5% margin of error, 95% confidence level, 50% prevalence, and 20% possible losses, in a population of 13,259 older individuals. The subjects answered the VES-13 and WHOQOL-bref questionnaires. They were divided into 3 subgroups: poorQoL (older individuals with self-reported very poor or poor QoL AND very dissatisfied or dissatisfied with their health), goodQoL (very good or good QoL AND very satisfied or satisfied with Health) and indeterminateQoL (NOT belonging to poorQoL or goodQoL subgroups). A receiver-operating characteristic (ROC) curve was performed with poorQoL (case) versus goodQoL (control) to determine the cutoff score in VES-13 and WHOQOL-bref. A diagnostic test using these cutoffs was carried out in all older individuals (n = 466). RESULTS: The VES-13 and WHOQOL-bref cutoff points to detect poorQoL were ≥ 2 and &lt; 60, respectively. The area under ROC curve of VES-13 and WHOQOL-bref was 0.741 (CI95% 0.659-0.823; p &lt; 0.001) and 0.934 (CI95% 0.881-0.987; p &lt; 0.001), respectively. In diagnostic tests, VES-13 showed 84% sensitivity and 98.2% negative predictive value, and WHOQOL-bref, 88% sensitivity and 99% negative predictive value. CONCLUSIONS: VES-13 score ≥ 2 and WHOQOL-bref score &lt; 60 adequately detected poorQoL in patients treated in primary health care. Our data suggest that older individuals with these scores require special treatment such as geriatrics collaborative care to improve this scenario, considering QoL impact on mortality.
DOI: 10.6084/m9.figshare.7942145
title: High definition endoscopy and "narrow band imaging" in the diagnosis of gastroesophageal reflux disease

description: Introduction: The gastroesophageal reflux disease is a common condition in the western world but less than half of patients present endoscopic abnormalities, making a standard procedure unsuitable for diagnosis. High definition endoscopy coupled with narrow band imaging has shown potential for differentiation of lesions and possible biopsy, allowing early diagnosis and treatment. Methods: This review describes the principles of biotic and their influence in obtaining images with better definition of the vessels in the mucosa, through the narrow band imaging. Selected papers using it in patients with reflux disease and Barrett's esophagus are analyzed in several ways, highlighting the findings and limitations. Conclusion: The meaning of the narrow band imaging in the endoscopic diagnosis of reflux disease will be defined by large scale studies, with different categories of patients, including assessment of symptoms and response to treatment.
DOI: 10.6084/m9.figshare.7942136
title: Fetal and maternal factors are associated with mortality due to circulatory system disorders in children

description: ABSTRACT OBJECTIVE To analyze the association of characteristics recorded at the time of birth, including weight, occurrence of asphyxia, gestation duration, maternal age and education level, with death from diseases or malformations of the circulatory system in children under 18 years of age. METHODS The Brazilian Information System on Live Births and Information System on Mortality databases were linked and evaluated following a longitudinal cohort analysis strategy. The following independent variables were evaluated: characteristics recorded at the time of birth, including weight, occurrence of asphyxia, gestation duration, maternal age and education level. Dependent variables were death from diseases or malformations of the circulatory system in children under 18 years of age. Crude relative risks were estimated and relative risks were adjusted for the variables. RESULTS 6,380 deaths were linked to 4,282,260 birth records, yielding 5,062 pairs considered as true. Low birth weight (RR = 2.26), asphyxia at 1 (RR = 1.72) and 5 minutes (RR = 1.51), prematurity (RR = 1.50), maternal age ≥ 40 years (RR = 2.06), and low maternal education level (RR = 1.45) increased the probability of death caused by circulatory system diseases. In the association with death by malformations of the circulatory system, the predictive variables showed the same association profile, but with greater intensity. CONCLUSIONS Fetal and maternal factors are associated with increased mortality due to diseases and malformations of the circulatory system. Measures to control these factors and improve access to their diagnosis and treatment would contribute to reducing the number of deaths caused by diseases and malformations of the circulatory system. However, the identification of environmental influences during gestation and birth on the risk of death should be carefully considered due to being influenced by genetic factors.
DOI: 10.6084/m9.figshare.7942139.v1
title: MICROBIOREACTORS AS ENGINEERING TOOLS FOR BIOPROCESS DEVELOPMENT

description: ABSTRACT Within the engineering and development of industrial bioprocesses, microbioreactors are microfluidic tools able to provide high-throughput screening tests in a fast and cheap manner by using small amounts of reagents. In addition, such tools are versatile and may allow a better controllability of parameters when compared to conventional bench-scale reactors. Consequentially, this technology has been gaining attention from the scientific community over the past years. In such scenario, this work provides a review study of the microbioreactor technology, outlining the origin, main concepts and principles of such technology, aiming to elucidate general questions that may emerge when studying such an approach. Past and current approaches are discussed aiming at drawing a comparative picture about such technology regarding future developments.
DOI: 10.6084/m9.figshare.7942142.v1
title: VES-13 and WHOQOL-bref cutoff points to detect quality of life in older adults in primary health care

description: ABSTRACT OBJECTIVE: To determine Vulnerable Elders Survey (VES-13) and WHOQOL-bref cutoff points to detect poor quality of life (QoL) in older individuals. METHODS: This is a cross-sectional study, performed in all primary health care units in Samambaia, DF, Brazil. The data were collected from August 2016 to May 2017. The sample size of 466 older individuals treated in primary health care was obtained considering a 5% margin of error, 95% confidence level, 50% prevalence, and 20% possible losses, in a population of 13,259 older individuals. The subjects answered the VES-13 and WHOQOL-bref questionnaires. They were divided into 3 subgroups: poorQoL (older individuals with self-reported very poor or poor QoL AND very dissatisfied or dissatisfied with their health), goodQoL (very good or good QoL AND very satisfied or satisfied with Health) and indeterminateQoL (NOT belonging to poorQoL or goodQoL subgroups). A receiver-operating characteristic (ROC) curve was performed with poorQoL (case) versus goodQoL (control) to determine the cutoff score in VES-13 and WHOQOL-bref. A diagnostic test using these cutoffs was carried out in all older individuals (n = 466). RESULTS: The VES-13 and WHOQOL-bref cutoff points to detect poorQoL were ≥ 2 and &lt; 60, respectively. The area under ROC curve of VES-13 and WHOQOL-bref was 0.741 (CI95% 0.659-0.823; p &lt; 0.001) and 0.934 (CI95% 0.881-0.987; p &lt; 0.001), respectively. In diagnostic tests, VES-13 showed 84% sensitivity and 98.2% negative predictive value, and WHOQOL-bref, 88% sensitivity and 99% negative predictive value. CONCLUSIONS: VES-13 score ≥ 2 and WHOQOL-bref score &lt; 60 adequately detected poorQoL in patients treated in primary health care. Our data suggest that older individuals with these scores require special treatment such as geriatrics collaborative care to improve this scenario, considering QoL impact on mortality.
DOI: 10.6084/m9.figshare.7942145.v1
title: High definition endoscopy and "narrow band imaging" in the diagnosis of gastroesophageal reflux disease

description: Introduction: The gastroesophageal reflux disease is a common condition in the western world but less than half of patients present endoscopic abnormalities, making a standard procedure unsuitable for diagnosis. High definition endoscopy coupled with narrow band imaging has shown potential for differentiation of lesions and possible biopsy, allowing early diagnosis and treatment. Methods: This review describes the principles of biotic and their influence in obtaining images with better definition of the vessels in the mucosa, through the narrow band imaging. Selected papers using it in patients with reflux disease and Barrett's esophagus are analyzed in several ways, highlighting the findings and limitations. Conclusion: The meaning of the narrow band imaging in the endoscopic diagnosis of reflux disease will be defined by large scale studies, with different categories of patients, including assessment of symptoms and response to treatment.
DOI: 10.6084/m9.figshare.7942124
title: Quality as perceived by nursing professionals in an accredited specialized hospital

description: ABSTRACT Objective: To identify quality of service in an accredited specialized hospital according to nursing professionals' expectations and perceptions. Method: This is a cross-sectional quantitative study with the participation of 34 employees, conducted from August to October 2017 by administration of an adapted and validated version of the SERVQUAL scale. Results: The interviewees reported as their highest expectations the transmission of confidence and provision of safe services, the latter also turning out to be the best perception of service. Promotional materials were considered as the least important expectation. The perception with the lowest scores was related to the time of service delivery at the institution, which may be associated with specific factors. Safety of service was considered as the quality dimension with greater relevance. Conclusion: It is highlighted the importance of measures for maintenance of schedules and preservation of good forms of promotion, communication and team training.
DOI: 10.6084/m9.figshare.7942130
title: Strategies to minimize medication errors in emergency units: an integrative review

description: ABSTRACT Objective: To assess the strategies used by the Nursing team to minimize medication errors in emergency units. Method: Integrative literature review in the PubMed, BDenf, Cochrane and LILACS databases. Timeless research, without language limitation, performed by peers. Articles published in full that answered the guiding question were included in research. Results: Educational strategies (conducting campaigns, elaborating explanatory manuals, creating a multidisciplinary committee involved in the prevention and reduction of adverse drug events); organizational (meetings, Deviance positive, creation of protocols and changes in the work process) and new technologies (implementation of prescription by computerized system, introduction of the unit doses and of the bar code in the administration of medicines) were evidenced in the studies with the purpose of minimizing medication errors in an emergency unit. Conclusion: The strategies identified were effective in minimizing medication errors in emergency units.
DOI: 10.6084/m9.figshare.7942136.v1
title: Fetal and maternal factors are associated with mortality due to circulatory system disorders in children

description: ABSTRACT OBJECTIVE To analyze the association of characteristics recorded at the time of birth, including weight, occurrence of asphyxia, gestation duration, maternal age and education level, with death from diseases or malformations of the circulatory system in children under 18 years of age. METHODS The Brazilian Information System on Live Births and Information System on Mortality databases were linked and evaluated following a longitudinal cohort analysis strategy. The following independent variables were evaluated: characteristics recorded at the time of birth, including weight, occurrence of asphyxia, gestation duration, maternal age and education level. Dependent variables were death from diseases or malformations of the circulatory system in children under 18 years of age. Crude relative risks were estimated and relative risks were adjusted for the variables. RESULTS 6,380 deaths were linked to 4,282,260 birth records, yielding 5,062 pairs considered as true. Low birth weight (RR = 2.26), asphyxia at 1 (RR = 1.72) and 5 minutes (RR = 1.51), prematurity (RR = 1.50), maternal age ≥ 40 years (RR = 2.06), and low maternal education level (RR = 1.45) increased the probability of death caused by circulatory system diseases. In the association with death by malformations of the circulatory system, the predictive variables showed the same association profile, but with greater intensity. CONCLUSIONS Fetal and maternal factors are associated with increased mortality due to diseases and malformations of the circulatory system. Measures to control these factors and improve access to their diagnosis and treatment would contribute to reducing the number of deaths caused by diseases and malformations of the circulatory system. However, the identification of environmental influences during gestation and birth on the risk of death should be carefully considered due to being influenced by genetic factors.
DOI: 10.6084/m9.figshare.7942121
title: Prevalence of smoking in nursing professionals of a cardiovascular hospital

description: ABSTRACT Objective: to identify the prevalence of smoking in nursing professionals and to determine the relationship of the habit with clinical and socio-demographic characteristics. Method: nursing professionals of a cardiovascular hospital answered a questionnaire on smoking and dependence degree, socio-demographic characteristics, personal and family background, smoking characteristics, motivational stages, depression, perceived and occupational stress. The relationship between the explanatory variables and smoking was investigated. Results: among 656 participants, 77.6% were non smokers, 12.2% former smokers, and 10.2% smokers. Most were female, with complete high school, Catholic, married, household income between three and five minimum wages, position as nursing assistant, had double shifts, and were responsible for family income. The nicotine dependence of smokers ranged from low to moderate. Conclusion: the study has shown low prevalence of smoking in nursing professionals. Education level, religion, marital status, job position, responsibility for family income, history of depression and alcoholism, chest "wheezing" and other symptoms were significantly associated with being a smoker or former smoker.
DOI: 10.6084/m9.figshare.7942130.v1
title: Strategies to minimize medication errors in emergency units: an integrative review

description: ABSTRACT Objective: To assess the strategies used by the Nursing team to minimize medication errors in emergency units. Method: Integrative literature review in the PubMed, BDenf, Cochrane and LILACS databases. Timeless research, without language limitation, performed by peers. Articles published in full that answered the guiding question were included in research. Results: Educational strategies (conducting campaigns, elaborating explanatory manuals, creating a multidisciplinary committee involved in the prevention and reduction of adverse drug events); organizational (meetings, Deviance positive, creation of protocols and changes in the work process) and new technologies (implementation of prescription by computerized system, introduction of the unit doses and of the bar code in the administration of medicines) were evidenced in the studies with the purpose of minimizing medication errors in an emergency unit. Conclusion: The strategies identified were effective in minimizing medication errors in emergency units.
DOI: 10.6084/m9.figshare.7942112
title: Estimate of the correction of sewage return rate in housing with rain water recovery systems: case study of Bauru city, SP, Brazil

description: ABSTRACT The return coefficient (f) of the sewage disposal system, which presents the ratio given by the volume of wastewater by the public supply system water volume is employed in the design and management of sanitary sewer collection system. The use of alternative sources, such as reuse and rainwater harvesting, are not considered by f. This article aims at applying the methodology to evaluate the potential release of rainwater in the collection and transportation of sanitary sewage system through recovery practices in Bauru city/SP. Variables were quoted by means of number of inhabitants. The statistical sampling procedure was applied for roof area determination. Results pointed out for f correction (f corrected ) values varying from 0,86 to 1.14 for Bauru city.
DOI: 10.6084/m9.figshare.7942124.v1
title: Quality as perceived by nursing professionals in an accredited specialized hospital

description: ABSTRACT Objective: To identify quality of service in an accredited specialized hospital according to nursing professionals' expectations and perceptions. Method: This is a cross-sectional quantitative study with the participation of 34 employees, conducted from August to October 2017 by administration of an adapted and validated version of the SERVQUAL scale. Results: The interviewees reported as their highest expectations the transmission of confidence and provision of safe services, the latter also turning out to be the best perception of service. Promotional materials were considered as the least important expectation. The perception with the lowest scores was related to the time of service delivery at the institution, which may be associated with specific factors. Safety of service was considered as the quality dimension with greater relevance. Conclusion: It is highlighted the importance of measures for maintenance of schedules and preservation of good forms of promotion, communication and team training.
DOI: 10.6084/m9.figshare.7942106
title: Follicular helper T cell in immunity and autoimmunity

description: The traditional concept that effector T helper (Th) responses are mediated by Th1/Th2 cell subtypes has been broadened by the recent demonstration of two new effector T helper cells, the IL-17 producing cells (Th17) and the follicular helper T cells (Tfh). These new subsets have many features in common, such as the ability to produce IL-21 and to express the IL-23 receptor (IL23R), the inducible co-stimulatory molecule ICOS, and the transcription factor c-Maf, all of them essential for expansion and establishment of the final pool of both subsets. Tfh cells differ from Th17 by their ability to home to B cell areas in secondary lymphoid tissue through interactions mediated by the chemokine receptor CXCR5 and its ligand CXCL13. These CXCR5+ CD4+ T cells are considered an effector T cell type specialized in B cell help, with a transcriptional profile distinct from Th1 and Th2 cells. The role of Tfh cells and its primary product, IL-21, on B-cell activation and differentiation is essential for humoral immunity against infectious agents. However, when deregulated, Tfh cells could represent an important mechanism contributing to exacerbated humoral response and autoantibody production in autoimmune diseases. This review highlights the importance of Tfh cells by focusing on their biology and differentiation processes in the context of normal immune response to infectious microorganisms and their role in the pathogenesis of autoimmune diseases.
DOI: 10.6084/m9.figshare.7942109
title: Gender and Sexuality Teaching-Learning in a Medical School in Brazil: Promoting Comprehensive Health Care and Human Rights

description: ABSTRACT The aim of this article is to present the structure of a curricular unit for the discussion of gender and sexuality, as well as the initial results of the implementation of this discussion in a medical course of a Brazilian Federal University. The Context / Input / Process / Product (CIPP) model for program evaluation was used to present the structure of this curricular unit, and the heterogeneity of the steps and paths taken for its realization (steps 1, 2 and 3 of the CIPP). It also presents the initial results of the implementation of this discussion on a medical course (Step 4 of the CIPP). In stage 1, a document analysis of the curriculum of the medical school under study was carried out; Stages 2 and 3 give a descriptive narrative of the process of planning and implementing the curricular unit, based on the Paulino & Raimondi Arch for the Teaching-Learning of Public Policies in interface with Care for Health Degrees Programs; In step 4, a retrospective pre-post questionnaire was filled out voluntarily, in the end of the intervention, to the students. It consisted of closed questions, using a 7-point Likert scale to assess the students’ perceptions about the improvement of their competences in the areas of gender and sexuality in health care, following this pedagogical experience. This step also included a descriptive and inferential statistical analysis, using the student’s t-test, the effect size calculation (Cohen’s d), and the general linear model of mixed design, to determine whether there is significant difference between the genders before and after the intervention of each of the questions. The results show that the intervention/curricular unit developed, through the Paulino & Raimondi Arch, was statistically significant, having a significant impact on the improvement of competences, from the students’ perspective, in relation to this theme. This impact was most evident in female gender. It is concluded that this pedagogical strategy proved to be powerful in education for the health professions, promoting integrality in health care regarding gender and sexuality issues, through the improvement of competences related to those issues, thereby promoting the principles of the Unified Health System (SUS – Sistema Único de Saúde), social justice, and human rights.