cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.22638416
title: Chloroquine and hydroxychloroquine in the environment and aquatic organisms: a review

description: Abstract Chloroquine and hydroxychloroquine are aminoquinolines used in the treatment of endemic diseases in Latin America such as malaria and non-endemic with wide prevalence such as rheumatoid arthritis and lupus erythematosus. Described as persistent, bioaccumulative, and dangerous for aquatic biota, chloroquine and hydroxychloroquine are considered emerging pollutants intensified by the COVID-19 pandemic, occurring in low concentrations that are not totally removed in wastewater treatment plants and are not covered by legislation. This article presents a theoretical approach based on literature review following a semi-systematic methodology covering detection strategies of the chloroquine and hydroxychloroquine drugs in effluent and receiving water bodies; estimates of environmental concentrations during the pandemic; methods that use degradation and removal of compounds from water; and toxic effects on aquatic biota. Concentrations previously detected and estimated in the aquatic environment can lead to significant changes in animal physiology analyzed from biomarker changes, behavior and mortality in studies with native and non-native species. Studies are necessary to reproduce and understand possible environmental scenarios adopting the indiscriminate use of drugs to serve as standards for environmentally safe concentrations when there is no specific legislation.
DOI: 10.6084/m9.figshare.22638416.v1
title: Chloroquine and hydroxychloroquine in the environment and aquatic organisms: a review

description: Abstract Chloroquine and hydroxychloroquine are aminoquinolines used in the treatment of endemic diseases in Latin America such as malaria and non-endemic with wide prevalence such as rheumatoid arthritis and lupus erythematosus. Described as persistent, bioaccumulative, and dangerous for aquatic biota, chloroquine and hydroxychloroquine are considered emerging pollutants intensified by the COVID-19 pandemic, occurring in low concentrations that are not totally removed in wastewater treatment plants and are not covered by legislation. This article presents a theoretical approach based on literature review following a semi-systematic methodology covering detection strategies of the chloroquine and hydroxychloroquine drugs in effluent and receiving water bodies; estimates of environmental concentrations during the pandemic; methods that use degradation and removal of compounds from water; and toxic effects on aquatic biota. Concentrations previously detected and estimated in the aquatic environment can lead to significant changes in animal physiology analyzed from biomarker changes, behavior and mortality in studies with native and non-native species. Studies are necessary to reproduce and understand possible environmental scenarios adopting the indiscriminate use of drugs to serve as standards for environmentally safe concentrations when there is no specific legislation.
DOI: 10.6084/m9.figshare.22638414
title: OUTSOURCING LABORATORY SERVICES FROM A COLOMBIAN AGRICULTURAL RESEARCH COMPANY USING THE FITRADEOFF METHOD UNDER MULTIPLE STAKEHOLDERS ANALYSIS

description: ABSTRACT Since most of the studies about outsourcing are focused on mathematical models, this paper seeks to support from theoretical bases the use of partial information to ease the decision-making process; the practical contribution is to apply the FITradeoff method for solving a multicriteria problem of an agricultural research company that seeks to decide about the need to outsource the operation in case to overhead the limited capacity of the analysis services. After the FITradeoff method was applied to elicit preferences from each decision-maker (DM), the results show whether or not it would be feasible to outsource a given service, and what the most promising options are. The method required the DMs to answer in less time only a few questions, which avoided placing an unnecessary cognitive burden on them and proved to be useful in assisting DMs in the decision-making.
DOI: 10.6084/m9.figshare.22638414.v1
title: OUTSOURCING LABORATORY SERVICES FROM A COLOMBIAN AGRICULTURAL RESEARCH COMPANY USING THE FITRADEOFF METHOD UNDER MULTIPLE STAKEHOLDERS ANALYSIS

description: ABSTRACT Since most of the studies about outsourcing are focused on mathematical models, this paper seeks to support from theoretical bases the use of partial information to ease the decision-making process; the practical contribution is to apply the FITradeoff method for solving a multicriteria problem of an agricultural research company that seeks to decide about the need to outsource the operation in case to overhead the limited capacity of the analysis services. After the FITradeoff method was applied to elicit preferences from each decision-maker (DM), the results show whether or not it would be feasible to outsource a given service, and what the most promising options are. The method required the DMs to answer in less time only a few questions, which avoided placing an unnecessary cognitive burden on them and proved to be useful in assisting DMs in the decision-making.
DOI: 10.6084/m9.figshare.22638420
title: Effect of propolis on Th2 and Th17 cells: interplay with EtxB- and LPS-treated dendritic cells

description: Dendritic cells (DCs) are antigen-presenting cells that drive the differentiation of T CD4+ cells into different profiles according to the nature of the antigen or immunomodulator. Propolis is a resinous product made by bees that has numerous pharmacological properties, including an immunomodulatory action. To assess whether propolis can modulate the activation of CD4+ T cells by stimulating DCs with heat-labile enterotoxin B subunit (EtxB) or lipopolysaccharide (LPS), we aimed to elucidate the mechanisms affected by propolis in the differential activation of T lymphocytes. Cell viability, lymphocyte proliferation, gene expression (GATA-3 and RORc), and cytokine production (interleukin (IL)-4 and IL-17A) were analyzed. Propolis, EtxB, and LPS induced a higher lymphoproliferation compared with the control. Propolis induced GATA-3 expression and, in combination with EtxB, maintained the baseline levels. Propolis alone or in combination with LPS inhibited RORc expression. EtxB alone and in combination with propolis increased IL-4 production. Propolis in combination with LPS prevented LPS-induced IL-17A production. These results opened perspectives for the study of biological events that may be favored by propolis by promoting Th2 activation or helping in the treatment of inflammatory conditions mediated by Th17 cells.
DOI: 10.6084/m9.figshare.22638420.v1
title: Effect of propolis on Th2 and Th17 cells: interplay with EtxB- and LPS-treated dendritic cells

description: Dendritic cells (DCs) are antigen-presenting cells that drive the differentiation of T CD4+ cells into different profiles according to the nature of the antigen or immunomodulator. Propolis is a resinous product made by bees that has numerous pharmacological properties, including an immunomodulatory action. To assess whether propolis can modulate the activation of CD4+ T cells by stimulating DCs with heat-labile enterotoxin B subunit (EtxB) or lipopolysaccharide (LPS), we aimed to elucidate the mechanisms affected by propolis in the differential activation of T lymphocytes. Cell viability, lymphocyte proliferation, gene expression (GATA-3 and RORc), and cytokine production (interleukin (IL)-4 and IL-17A) were analyzed. Propolis, EtxB, and LPS induced a higher lymphoproliferation compared with the control. Propolis induced GATA-3 expression and, in combination with EtxB, maintained the baseline levels. Propolis alone or in combination with LPS inhibited RORc expression. EtxB alone and in combination with propolis increased IL-4 production. Propolis in combination with LPS prevented LPS-induced IL-17A production. These results opened perspectives for the study of biological events that may be favored by propolis by promoting Th2 activation or helping in the treatment of inflammatory conditions mediated by Th17 cells.
DOI: 10.6084/m9.figshare.22638423.v1
title: Efficacy and safety of Ixekizumab vs. low-dose IL-2 vs. Colchicine vs. standard of care in the treatment of patients hospitalized with moderate-to-critical COVID-19: A pilot randomized clinical trial (STRUCK: Survival Trial Using Cytokine Inhibitors)

description: ABSTRACT Background: Cases of coronavirus disease 2019 (COVID-19) requiring hospitalization continue to appear in vulnerable populations, highlighting the importance of novel treatments. The hyperinflammatory response underlies the severity of the disease, and targeting this pathway may be useful. Herein, we tested whether immunomodulation focusing on interleukin (IL)-6, IL-17, and IL-2, could improve the clinical outcomes of patients admitted with COVID-19. Methods: This multicenter, open-label, prospective, randomized controlled trial was conducted in Brazil. Sixty hospitalized patients with moderate-to-critical COVID-19 received in addition to standard of care (SOC): IL-17 inhibitor (ixekizumab 80 mg SC/week) 1 dose every 4 weeks; low-dose IL-2 (1.5 million IU per day) for 7 days or until discharge; or indirect IL-6 inhibitor (colchicine) orally (0.5 mg) every 8 hours for 3 days, followed by 4 weeks at 0.5 mg 2x/day; or SOC alone. The primary outcome was accessed in the “per protocol” population as the proportion of patients with clinical improvement, defined as a decrease greater or equal to two points on the World Health Organization’s (WHO) seven-category ordinal scale by day 28. Results: All treatments were safe, and the efficacy outcomes did not differ significantly from those of SOC. Interestingly, in the colchicine group, all participants had an improvement of greater or equal to two points on the WHO seven-category ordinal scale and no deaths or patient deterioration were observed. Conclusions: Ixekizumab, colchicine, and IL-2 were demonstrated to be safe but ineffective for COVID-19 treatment. These results must be interpreted cautiously because of the limited sample size.
DOI: 10.6084/m9.figshare.22638423
title: Efficacy and safety of Ixekizumab vs. low-dose IL-2 vs. Colchicine vs. standard of care in the treatment of patients hospitalized with moderate-to-critical COVID-19: A pilot randomized clinical trial (STRUCK: Survival Trial Using Cytokine Inhibitors)

description: ABSTRACT Background: Cases of coronavirus disease 2019 (COVID-19) requiring hospitalization continue to appear in vulnerable populations, highlighting the importance of novel treatments. The hyperinflammatory response underlies the severity of the disease, and targeting this pathway may be useful. Herein, we tested whether immunomodulation focusing on interleukin (IL)-6, IL-17, and IL-2, could improve the clinical outcomes of patients admitted with COVID-19. Methods: This multicenter, open-label, prospective, randomized controlled trial was conducted in Brazil. Sixty hospitalized patients with moderate-to-critical COVID-19 received in addition to standard of care (SOC): IL-17 inhibitor (ixekizumab 80 mg SC/week) 1 dose every 4 weeks; low-dose IL-2 (1.5 million IU per day) for 7 days or until discharge; or indirect IL-6 inhibitor (colchicine) orally (0.5 mg) every 8 hours for 3 days, followed by 4 weeks at 0.5 mg 2x/day; or SOC alone. The primary outcome was accessed in the “per protocol” population as the proportion of patients with clinical improvement, defined as a decrease greater or equal to two points on the World Health Organization’s (WHO) seven-category ordinal scale by day 28. Results: All treatments were safe, and the efficacy outcomes did not differ significantly from those of SOC. Interestingly, in the colchicine group, all participants had an improvement of greater or equal to two points on the WHO seven-category ordinal scale and no deaths or patient deterioration were observed. Conclusions: Ixekizumab, colchicine, and IL-2 were demonstrated to be safe but ineffective for COVID-19 treatment. These results must be interpreted cautiously because of the limited sample size.
DOI: 10.6084/m9.figshare.22638425
title: Development of core-shell nanocomposites containing iron oxide,silica and samarium for potential application in cancer treatments involving brachytherapy and magnetic hyperthermia

description: Abstract Nanocomposites formed of natural-origin iron oxide nanoparticles (magnetite and maghemite, Fe3O4 and γ-Fe2O3, respectively) were processed using the sol-gel process into core-shell structures containing silica and samarium to investigate their potential for applications in cancer treatments combining hyperthermia and brachytherapy. Mössbauer characterization showed that the iron oxides contained 64% magnetite, 18% hematite, 12% maghemite, and exhibit superparamagnetic behavior at room temperature. Transmission electron microscopy determined that the iron oxide particles were smaller than 15 nm, while magnetization was measured at 5 emu/g. Fourier transform infrared indicated the material was formed of Si-O-Si and Fe-O-Si bonds, while X-ray diffraction showed bands of amorphous silica from 5° to 23° and bands of iron oxide phases. X-ray fluorescence indicated 5.17% of incorporated samarium. The nanocomposite suspensions were subjected to an alternating magnetic field and the resulting heat dissipation was measured, falling within the ideal range for hyperthermia applications. Theoretical dosimetric calculation determined significant radioactive activity of 1.68x10-8 MBq.mg-1.Φ -1 after 24h decay time for 153Sm. The characteristics and behavior of these nanocomposites indicate that they may offer promise in applications involving hyperthermia for cancer treatment and a more accessible source for brachytherapy materials.
DOI: 10.6084/m9.figshare.22638425.v1
title: Development of core-shell nanocomposites containing iron oxide,silica and samarium for potential application in cancer treatments involving brachytherapy and magnetic hyperthermia

description: Abstract Nanocomposites formed of natural-origin iron oxide nanoparticles (magnetite and maghemite, Fe3O4 and γ-Fe2O3, respectively) were processed using the sol-gel process into core-shell structures containing silica and samarium to investigate their potential for applications in cancer treatments combining hyperthermia and brachytherapy. Mössbauer characterization showed that the iron oxides contained 64% magnetite, 18% hematite, 12% maghemite, and exhibit superparamagnetic behavior at room temperature. Transmission electron microscopy determined that the iron oxide particles were smaller than 15 nm, while magnetization was measured at 5 emu/g. Fourier transform infrared indicated the material was formed of Si-O-Si and Fe-O-Si bonds, while X-ray diffraction showed bands of amorphous silica from 5° to 23° and bands of iron oxide phases. X-ray fluorescence indicated 5.17% of incorporated samarium. The nanocomposite suspensions were subjected to an alternating magnetic field and the resulting heat dissipation was measured, falling within the ideal range for hyperthermia applications. Theoretical dosimetric calculation determined significant radioactive activity of 1.68x10-8 MBq.mg-1.Φ -1 after 24h decay time for 153Sm. The characteristics and behavior of these nanocomposites indicate that they may offer promise in applications involving hyperthermia for cancer treatment and a more accessible source for brachytherapy materials.
DOI: 10.6084/m9.figshare.22638428
title: The influence of network ties on entrepreneurial orientation in Mexican farmers: An institutional perspective

description: ABSTRACT Purpose: This study focuses on analyzing the institutional context and collaborative networks affecting farmers’ entrepreneurial capacity in Mexico. Originality/value: Both the institutional framework and collaborative networks are part of the environment faced by the farmer and empower them to decide about their business, being decisive elements to generate confidence in the environment and reduce the risk of assuming economic responsibilities Design/methodology/approach: We incorporate the moderating effect of the institutional context considering its influence on collaboration networks. The statistical technique of structural equation models was used to test the hypotheses. The sample comprised 192 farmers from the state of Aguascalientes, Mexico. Findings: The results showed significant and positive effects of institutional pillars and collaborative networks on the capacity to undertake. Regarding the non-significant effects of the institutional context as a moderating variable, further research is suggested to review the relationship of institutional pillars with collaboration networks and their possible negative relationship. Institutional pillars represent the perception of the social structure relevant to measuring society’s position regarding the capacities, in this case, of rural entrepreneurship, especially when making public policies. The impact of current government actions on the commercial activity should be considered. Subsequently, public policies must have a practical application by the legal framework and the formation of an environment of certainty based on the normative and cognitive pillars of the institutional context.
DOI: 10.6084/m9.figshare.22638428.v1
title: The influence of network ties on entrepreneurial orientation in Mexican farmers: An institutional perspective

description: ABSTRACT Purpose: This study focuses on analyzing the institutional context and collaborative networks affecting farmers’ entrepreneurial capacity in Mexico. Originality/value: Both the institutional framework and collaborative networks are part of the environment faced by the farmer and empower them to decide about their business, being decisive elements to generate confidence in the environment and reduce the risk of assuming economic responsibilities Design/methodology/approach: We incorporate the moderating effect of the institutional context considering its influence on collaboration networks. The statistical technique of structural equation models was used to test the hypotheses. The sample comprised 192 farmers from the state of Aguascalientes, Mexico. Findings: The results showed significant and positive effects of institutional pillars and collaborative networks on the capacity to undertake. Regarding the non-significant effects of the institutional context as a moderating variable, further research is suggested to review the relationship of institutional pillars with collaboration networks and their possible negative relationship. Institutional pillars represent the perception of the social structure relevant to measuring society’s position regarding the capacities, in this case, of rural entrepreneurship, especially when making public policies. The impact of current government actions on the commercial activity should be considered. Subsequently, public policies must have a practical application by the legal framework and the formation of an environment of certainty based on the normative and cognitive pillars of the institutional context.
DOI: 10.6084/m9.figshare.22638426.v1
title: Effects of surface hardeners on the performance of concrete floors prepared with different mixture proportions

description: Abstract Constant growth in the concrete floor sector claims new techniques to improve concrete performance and avoid undesirable issues. In this way, materials used in concrete floors are essential, and it is critical to investigate them. Therefore, this study evaluated the influence of surface hardeners on the surface hardness determined by the rebound hammer test of concrete floors prepared with distinct water/cement ratios, curing ages, and cement types. The control parameters of the concrete’s production, including the compressive strength, flexural tensile strength, and bleeding tests were analyzed. In addition, data were assessed by multifactorial analysis of variance (ANOVA). Thus, hardeners increased the surface resistance of the composites, therefore reducing the chances of pathological manifestations occurring. Taken together, we demonstrated that hardeners improved the concrete surface prepared with all mixture proportions, but it was more significant when using the cementitious hardener and higher w/c content (0.6).
DOI: 10.6084/m9.figshare.22638426
title: Effects of surface hardeners on the performance of concrete floors prepared with different mixture proportions

description: Abstract Constant growth in the concrete floor sector claims new techniques to improve concrete performance and avoid undesirable issues. In this way, materials used in concrete floors are essential, and it is critical to investigate them. Therefore, this study evaluated the influence of surface hardeners on the surface hardness determined by the rebound hammer test of concrete floors prepared with distinct water/cement ratios, curing ages, and cement types. The control parameters of the concrete’s production, including the compressive strength, flexural tensile strength, and bleeding tests were analyzed. In addition, data were assessed by multifactorial analysis of variance (ANOVA). Thus, hardeners increased the surface resistance of the composites, therefore reducing the chances of pathological manifestations occurring. Taken together, we demonstrated that hardeners improved the concrete surface prepared with all mixture proportions, but it was more significant when using the cementitious hardener and higher w/c content (0.6).
DOI: 10.6084/m9.figshare.22638429.v1
title: Indigenous identity: a view from social psychology

description: Abstract This study consists in a integrative review whose aim is to identify how social psychology has abroached the questions relating to indigenous identity. The survey was done from articles that deal with indigenous questions in the perspective of social psychology in electronic bases: SciELO, Pepsic, LILACS, BVS-Psi e APA. The descriptors were: ethnic identity, indigenous, indian, social identity and social psychology. By considering the inclusion and exclusion criteria, 19 national and internacional studies were compiled, referring to the last decade, published Psychology magazines, by making evident the recent character of studies that may approximate Social Psychology and indigenous identity. By means of accomplished survey, it was found that the publications about the theme were organized in four axes: (1) comprehension of ethnic identity to arise from Social Psychology; (2) Social representations, preconception and discrimination against indigenous; (3) Effects of the interethnic relationship for indigenous and (4) The challenges of the relationship between the researcher and indigenous.
DOI: 10.6084/m9.figshare.22638429
title: Indigenous identity: a view from social psychology

description: Abstract This study consists in a integrative review whose aim is to identify how social psychology has abroached the questions relating to indigenous identity. The survey was done from articles that deal with indigenous questions in the perspective of social psychology in electronic bases: SciELO, Pepsic, LILACS, BVS-Psi e APA. The descriptors were: ethnic identity, indigenous, indian, social identity and social psychology. By considering the inclusion and exclusion criteria, 19 national and internacional studies were compiled, referring to the last decade, published Psychology magazines, by making evident the recent character of studies that may approximate Social Psychology and indigenous identity. By means of accomplished survey, it was found that the publications about the theme were organized in four axes: (1) comprehension of ethnic identity to arise from Social Psychology; (2) Social representations, preconception and discrimination against indigenous; (3) Effects of the interethnic relationship for indigenous and (4) The challenges of the relationship between the researcher and indigenous.