cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.5517/ccdc.csd.cc2kfnpc
title: CCDC 2366623: Experimental Crystal Structure Determination

description: Related Article: Milan Gembicky|2024|CSD Communication|||
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2kfnqd
title: CCDC 2366624: Experimental Crystal Structure Determination

description: Related Article: Milan Gembicky|2024|CSD Communication|||
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.18738/t8/uoes4s/jmxor3
title: Vid2RealPhase2_P27_vlp16_000171.bin
DOI: 10.18738/t8/uoes4s/7j99xm
title: Vid2RealPhase2_P27_vlp16_000266.bin
DOI: 10.18738/t8/uoes4s/naiq7y
title: Vid2RealPhase2_P27_vlp16_000103.bin
DOI: 10.18738/t8/uoes4s/chtb9q
title: Vid2RealPhase2_P27_vlp16_000214.bin
DOI: 10.18738/t8/uoes4s/b4obbb
title: Vid2RealPhase2_P27_vlp16_000027.bin
DOI: 10.18738/t8/uoes4s/vs1hho
title: Vid2RealPhase2_P27_vlp16_000268.bin
DOI: 10.18738/t8/uoes4s/tqrs5w
title: Vid2RealPhase2_P27_vlp16_000020.bin
DOI: 10.5517/ccdc.csd.cc2hkyst
title: CCDC 2311167: Experimental Crystal Structure Determination

description: Related Article: Koh sugamata|2024|CSD Communication|||
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.18738/t8/uoes4s/6w6wjx
title: Vid2RealPhase2_P27_vlp16_000178.bin
DOI: 10.18738/t8/uoes4s/3tuycz
title: Vid2RealPhase2_P27_vlp16_000104.bin
DOI: 10.18738/t8/uoes4s/stve7x
title: Vid2RealPhase2_P27_vlp16_000213.bin
DOI: 10.18738/t8/uoes4s/f69tsw
title: Vid2RealPhase2_P27_vlp16_000015.bin
DOI: 10.18738/t8/uoes4s/h0t0fq
title: Vid2RealPhase2_P27_vlp16_000302.bin
DOI: 10.18738/t8/uoes4s/blxsje
title: Vid2RealPhase2_P27_vlp16_000069.bin
DOI: 10.18738/t8/uoes4s/wvffkx
title: Vid2RealPhase2_P27_vlp16_000226.bin
DOI: 10.18738/t8/uoes4s/mbshve
title: Vid2RealPhase2_P27_vlp16_000131.bin
DOI: 10.18738/t8/uoes4s/ruyvdh
title: Vid2RealPhase2_P27_vlp16_000221.bin
DOI: 10.18738/t8/uoes4s/e2wsge
title: Vid2RealPhase2_P27_vlp16_000136.bin
DOI: 10.18738/t8/uoes4s/xetvxk
title: Vid2RealPhase2_P27_vlp16_000012.bin
DOI: 10.18738/t8/uoes4s/wzcipu
title: Vid2RealPhase2_P27_vlp16_000305.bin
DOI: 10.18738/t8/uoes4s/ijzqmw
title: Vid2RealPhase2_P27_vlp16_000060.bin
DOI: 10.18738/t8/uoes4s/mkhkpm
title: Vid2RealPhase2_P27_vlp16_000138.bin
DOI: 10.15468/dl.wara5n
title: Occurrence Download

description: A dataset containing 272 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Hyacinthella pallasiana (Steven) Losinsk."
 ]
}

 The dataset includes 272 records from 20 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0005899-241007104925546/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.18738/t8/uoes4s/dzk8yf
title: Vid2RealPhase2_P27_vlp16_000253.bin
DOI: 10.18738/t8/uoes4s/pdbbmq
title: Vid2RealPhase2_P27_vlp16_000195.bin
DOI: 10.18738/t8/uoes4s/2rouoe
title: Vid2RealPhase2_P27_vlp16_000144.bin
DOI: 10.18738/t8/uoes4s/zvaxgf
title: Vid2RealPhase2_P27_vlp16_000282.bin
DOI: 10.18738/t8/uoes4s/lcgffb
title: Vid2RealPhase2_P27_vlp16_000254.bin
DOI: 10.18738/t8/uoes4s/pq0rrp
title: Vid2RealPhase2_P27_vlp16_000192.bin
DOI: 10.18738/t8/uoes4s/6omxsx
title: Vid2RealPhase2_P27_vlp16_000143.bin
DOI: 10.18738/t8/uoes4s/2cray0
title: Vid2RealPhase2_P27_vlp16_000285.bin
DOI: 10.18738/t8/uoes4s/z3wuyg
title: Vid2RealPhase2_P27_vlp16_000067.bin
DOI: 10.18738/t8/uoes4s/jxbxpg
title: Vid2RealPhase2_P27_vlp16_000228.bin
DOI: 10.18738/t8/uoes4s/mznijd
title: Vid2RealPhase2_P27_vlp16_000271.bin
DOI: 10.18738/t8/uoes4s/z9diyp
title: Vid2RealPhase2_P27_vlp16_000166.bin
DOI: 10.18738/t8/uoes4s/qpb1jb
title: Vid2RealPhase2_P27_vlp16_000042.bin
DOI: 10.18738/t8/uoes4s/wpxlms
title: Vid2RealPhase2_P27_vlp16_000093.bin
DOI: 10.18738/t8/uoes4s/aboh5u
title: Vid2RealPhase2_P27_vlp16_000045.bin
DOI: 10.18738/t8/uoes4s/x9b74u
title: Vid2RealPhase2_P27_vlp16_000094.bin
DOI: 10.18738/t8/uoes4s/yg2cjq
title: Vid2RealPhase2_P27_vlp16_000276.bin
DOI: 10.18738/t8/uoes4s/ho5bty
title: Vid2RealPhase2_P27_vlp16_000161.bin
DOI: 10.18738/t8/uoes4s/gc37bf
title: Vid2RealPhase2_P27_vlp16_000039.bin
DOI: 10.18738/t8/uoes4s/axki9s
title: Vid2RealPhase2_P27_vlp16_000204.bin
DOI: 10.18738/t8/uoes4s/sm0par
title: Vid2RealPhase2_P27_vlp16_000113.bin
DOI: 10.15468/dl.2zvwmf
title: Occurrence Download

description: A dataset containing 1453 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Dipodomys californicus Merriam, 1890"
 ]
}

 The dataset includes 1453 records from 33 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0005900-241007104925546/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.18738/t8/uoes4s/vy1pnx
title: Vid2RealPhase2_P27_vlp16_000278.bin
DOI: 10.18738/t8/uoes4s/leetof
title: Vid2RealPhase2_P27_vlp16_000037.bin
DOI: 10.18738/t8/uoes4s/mrvjdn
title: Vid2RealPhase2_P27_vlp16_000320.bin
DOI: 10.18738/t8/uoes4s/liwiqg
title: Vid2RealPhase2_P27_vlp16_000168.bin
DOI: 10.18738/t8/uoes4s/ic0khj
title: Vid2RealPhase2_P27_vlp16_000030.bin
DOI: 10.18738/t8/uoes4s/km9dvh
title: Vid2RealPhase2_P27_vlp16_000203.bin
DOI: 10.18738/t8/uoes4s/i5mlco
title: Vid2RealPhase2_P27_vlp16_000114.bin
DOI: 10.18738/t8/uoes4s/hlxso2
title: Vid2RealPhase2_P27_vlp16_000312.bin
DOI: 10.18738/t8/uoes4s/dattyk
title: Vid2RealPhase2_P27_vlp16_000005.bin
DOI: 10.18738/t8/uoes4s/3utdmw
title: Vid2RealPhase2_P27_vlp16_000121.bin
DOI: 10.18738/t8/uoes4s/w8ub6r
title: Vid2RealPhase2_P27_vlp16_000236.bin
DOI: 10.18738/t8/uoes4s/ufdipq
title: Vid2RealPhase2_P27_vlp16_000079.bin
DOI: 10.18738/t8/uoes4s/st6n09
title: Vid2RealPhase2_P27_vlp16_000126.bin
DOI: 10.18738/t8/uoes4s/r92u6k
title: Vid2RealPhase2_P27_vlp16_000231.bin
DOI: 10.18738/t8/uoes4s/b8qrru
title: Vid2RealPhase2_P27_vlp16_000315.bin
DOI: 10.18738/t8/uoes4s/gtpwrh
title: Vid2RealPhase2_P27_vlp16_000002.bin
DOI: 10.18738/t8/uoes4s/modiqd
title: Vid2RealPhase2_P27_vlp16_000128.bin
DOI: 10.18738/t8/uoes4s/uqrvfd
title: Vid2RealPhase2_P27_vlp16_000070.bin
DOI: 10.18738/t8/uoes4s/u4gfal
title: Vid2RealPhase2_P27_vlp16_000154.bin
DOI: 10.18738/t8/uoes4s/lwevjs
title: Vid2RealPhase2_P27_vlp16_000292.bin
DOI: 10.18738/t8/uoes4s/ax40r7
title: Vid2RealPhase2_P27_vlp16_000243.bin
DOI: 10.18738/t8/uoes4s/bow64u
title: Vid2RealPhase2_P27_vlp16_000185.bin
DOI: 10.18738/t8/uoes4s/dibqli
title: Vid2RealPhase2_P27_vlp16_000153.bin
DOI: 10.18738/t8/uoes4s/8ulkrq
title: Vid2RealPhase2_P27_vlp16_000295.bin
DOI: 10.18738/t8/uoes4s/s6vutw
title: Vid2RealPhase2_P27_vlp16_000244.bin
DOI: 10.18738/t8/uoes4s/fqeqer
title: Vid2RealPhase2_P27_vlp16_000182.bin
DOI: 10.18738/t8/uoes4s/uuq7ql
title: Vid2RealPhase2_P27_vlp16_000238.bin
DOI: 10.18738/t8/uoes4s/4bnwer
title: Vid2RealPhase2_P27_vlp16_000077.bin
DOI: 10.18738/t8/uoes4s/emd6ft
title: Vid2RealPhase2_P27_vlp16_000255.bin
DOI: 10.15468/dl.g3ftc3
title: Occurrence Download

description: A dataset containing 240 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Continent is Europe",
 "Country is Germany",
 "OccurrenceStatus is Present",
 "TaxonKey is Bubalus bubalis (Linnaeus, 1758)"
 ]
}

 The dataset includes 240 records from 7 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0005901-241007104925546/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.18738/t8/uoes4s/ga108i
title: Vid2RealPhase2_P27_vlp16_000193.bin
DOI: 10.18738/t8/uoes4s/u6i7u1
title: Vid2RealPhase2_P27_vlp16_000142.bin
DOI: 10.18738/t8/uoes4s/szgfke
title: Vid2RealPhase2_P27_vlp16_000284.bin
DOI: 10.18738/t8/uoes4s/pkko6r
title: Vid2RealPhase2_P27_vlp16_000066.bin
DOI: 10.18738/t8/uoes4s/7tqee1
title: Vid2RealPhase2_P27_vlp16_000229.bin
DOI: 10.18738/t8/uoes4s/ec9zc1
title: Vid2RealPhase2_P27_vlp16_000061.bin
DOI: 10.18738/t8/uoes4s/xpai0a
title: Vid2RealPhase2_P27_vlp16_000139.bin
DOI: 10.18738/t8/uoes4s/t9al9a
title: Vid2RealPhase2_P27_vlp16_000252.bin
DOI: 10.18738/t8/uoes4s/dtnwmt
title: Vid2RealPhase2_P27_vlp16_000194.bin
DOI: 10.18738/t8/uoes4s/7qhtc7
title: Vid2RealPhase2_P27_vlp16_000145.bin
DOI: 10.18738/t8/uoes4s/dbz8hr
title: Vid2RealPhase2_P27_vlp16_000283.bin
DOI: 10.18738/t8/uoes4s/kc85gb
title: Vid2RealPhase2_P27_vlp16_000220.bin
DOI: 10.18738/t8/uoes4s/dxkfpg
title: Vid2RealPhase2_P27_vlp16_000137.bin
DOI: 10.18738/t8/uoes4s/nyvui3
title: Vid2RealPhase2_P27_vlp16_000013.bin
DOI: 10.18738/t8/uoes4s/m2uebw
title: Vid2RealPhase2_P27_vlp16_000304.bin
DOI: 10.18738/t8/uoes4s/yby2c6
title: Vid2RealPhase2_P27_vlp16_000014.bin
DOI: 10.18738/t8/uoes4s/bgptsz
title: Vid2RealPhase2_P27_vlp16_000303.bin
DOI: 10.18738/t8/uoes4s/g4pjuu
title: Vid2RealPhase2_P27_vlp16_000068.bin
DOI: 10.18738/t8/uoes4s/4denbr
title: Vid2RealPhase2_P27_vlp16_000227.bin
DOI: 10.18738/t8/uoes4s/f26ezk
title: Vid2RealPhase2_P27_vlp16_000130.bin
DOI: 10.18738/t8/uoes4s/ow7vdz
title: Vid2RealPhase2_P27_vlp16_000021.bin
DOI: 10.18738/t8/uoes4s/gfc9yp
title: Vid2RealPhase2_P27_vlp16_000179.bin
DOI: 10.18738/t8/uoes4s/hq0ilj
title: Vid2RealPhase2_P27_vlp16_000105.bin
DOI: 10.18738/t8/uoes4s/11grcv
title: Vid2RealPhase2_P27_vlp16_000212.bin
DOI: 10.18738/t8/uoes4s/buvuom
title: Vid2RealPhase2_P27_vlp16_000102.bin
DOI: 10.18738/t8/uoes4s/plrq8m
title: Vid2RealPhase2_P27_vlp16_000215.bin
DOI: 10.18738/t8/uoes4s/pwgik0
title: Vid2RealPhase2_P27_vlp16_000026.bin
DOI: 10.18738/t8/uoes4s/q07dfn
title: Vid2RealPhase2_P27_vlp16_000269.bin
DOI: 10.18738/t8/uoes4s/ejkyuh
title: Vid2RealPhase2_P27_vlp16_000085.bin
DOI: 10.18738/t8/uoes4s/mkeakn
title: Vid2RealPhase2_P27_vlp16_000054.bin
DOI: 10.18738/t8/uoes4s/owju2z
title: Vid2RealPhase2_P27_vlp16_000028.bin
DOI: 10.18738/t8/uoes4s/6jxzl8
title: Vid2RealPhase2_P27_vlp16_000170.bin
DOI: 10.18738/t8/uoes4s/4dlexm
title: Vid2RealPhase2_P27_vlp16_000267.bin
DOI: 10.18738/t8/uoes4s/8inkp6
title: Vid2RealPhase2_P27_vlp16_000177.bin
DOI: 10.21227/2geh-em09
title: Characterizing and Evaluating Mental Health Misinformation on Social Media: A Qualitative and Deep Learning-Based Study

description: Social media dramatically facilitates social communications and information sharing on the Internet. However, social media also widely and quickly spread mental health misinformation and then amplifies the hazards of these misinformation for public health. Therefore, eliminating mental health misinformation on social media is indispensable and urgent. Unfortunately, information on social media is characterized by diversity, real-time, and wide dissemination. It is impossible to manually evaluate and eliminate massive mental health misinformation on social media. To address this challenge, the present study used qualitative and deep learning-based methods to automatically characterize and evaluate mental health misinformation on social media. Specifically, the present study incorporated expert opinions and specific characteristics of social media information to conduct a comprehensive credibility assessment rater guideline through qualitative methods. A detailed 21 fine-grained classification system comprising 7 key dimensions was developed, and a high-quality dataset of 814 social media posts related to mental health was collected by web crawler and then manually annotated according to this system.  Furthermore, this study developed a deep learning-based monitoring framework trained by the dataset for characterizing and evaluating mental health information. In sum, the present study developed three fine tuned deep learning models to efficiently and automatically characterize and evaluate mental health misinformation on social media. These models have the potential to improve the reliability and accuracy of mental health information on social media platforms.
DOI: 10.18738/t8/uoes4s/8mssvi
title: Vid2RealPhase2_P27_vlp16_000260.bin
DOI: 10.18738/t8/uoes4s/vsunfd
title: Vid2RealPhase2_P27_vlp16_000082.bin
DOI: 10.18738/t8/uoes4s/slysbb
title: Vid2RealPhase2_P27_vlp16_000053.bin
DOI: 10.18738/t8/uoes4s/wqyqu1
title: Vid2RealPhase2_P27_kinect_000041.png
DOI: 10.18738/t8/uoes4s/aobdz0
title: Vid2RealPhase2_P27_kinect_000046.png
DOI: 10.18738/t8/uoes4s/exdh0c
title: Vid2RealPhase2_P27_kinect_000048.png
DOI: 10.18738/t8/uoes4s/gobodm
title: Vid2RealPhase2_P27_kinect_000034.png
DOI: 10.18738/t8/uoes4s/kgpici
title: Vid2RealPhase2_P27_kinect_000033.png
DOI: 10.18738/t8/uoes4s/ubfqba
title: Vid2RealPhase2_P27_kinect_000006.png
DOI: 10.18738/t8/uoes4s/2zfjue
title: Vid2RealPhase2_P27_kinect_000001.png
DOI: 10.18738/t8/uoes4s/plifvn
title: Vid2RealPhase2_P27_kinect_000073.png
DOI: 10.18738/t8/uoes4s/7mqxsa
title: Vid2RealPhase2_P27_kinect_000008.png
DOI: 10.6084/m9.figshare.27200847
title: <b>Efficacy and Safety of Eight-Week Therapy with Ashwagandha Root Extract in Improvement of Sexual Health in Healthy Men: Findings of a Prospective, Randomized, Double-Blind, Placebo-Controlled Study</b>

description: Ashwagandha, a traditional Indian Ayurvedic remedy, an adaptogen, may improve sexual dysfunction in men and women. This 8-week prospective, double-blind, randomized, placebo-controlled study evaluated the efficacy and safety of Ashwagandha Root Extract (ARE) on improving sexual health in healthy adult men based on Satisfying Sexual Events (SSEs), the Sexual Desire Inventory (SDI-2), the International Index of Erectile Function (IIEF) score, semen parameters and the Quality Of Life (QOL) using the SF-12 tool. A total of 100 healthy men aged 30 to 50 years were randomly assigned to receive ARE 300 mg twice daily (n=50), or identical placebo (n=50) in a 1:1 ratio for 8 weeks. Study assessments were done at baseline, week 2, week 4, and week 8. Three participants from ARE and four participants from the placebo group were excluded due to follow-up loss. The efficacy analyses were done on Per-Protocol (PP) dataset of 93, whereas safety analyses were done on all 100 participants. Significant improvements were observed with ARE for semen volume (p=0.005), sperm number (p=0.006), sperm concentration (p=0.007), and sperm morphology (p=0.007). The improvement in scores was better with ARE for SDI-2 (p&lt;0.05), orgasm and sexual desire domains of IIEF (p&lt;0.05), and SF-12 (p&lt;0.0001). No adverse events were reported in the study.
DOI: 10.6084/m9.figshare.27200847.v1
title: <b>Efficacy and Safety of Eight-Week Therapy with Ashwagandha Root Extract in Improvement of Sexual Health in Healthy Men: Findings of a Prospective, Randomized, Double-Blind, Placebo-Controlled Study</b>

description: Ashwagandha, a traditional Indian Ayurvedic remedy, an adaptogen, may improve sexual dysfunction in men and women. This 8-week prospective, double-blind, randomized, placebo-controlled study evaluated the efficacy and safety of Ashwagandha Root Extract (ARE) on improving sexual health in healthy adult men based on Satisfying Sexual Events (SSEs), the Sexual Desire Inventory (SDI-2), the International Index of Erectile Function (IIEF) score, semen parameters and the Quality Of Life (QOL) using the SF-12 tool. A total of 100 healthy men aged 30 to 50 years were randomly assigned to receive ARE 300 mg twice daily (n=50), or identical placebo (n=50) in a 1:1 ratio for 8 weeks. Study assessments were done at baseline, week 2, week 4, and week 8. Three participants from ARE and four participants from the placebo group were excluded due to follow-up loss. The efficacy analyses were done on Per-Protocol (PP) dataset of 93, whereas safety analyses were done on all 100 participants. Significant improvements were observed with ARE for semen volume (p=0.005), sperm number (p=0.006), sperm concentration (p=0.007), and sperm morphology (p=0.007). The improvement in scores was better with ARE for SDI-2 (p&lt;0.05), orgasm and sexual desire domains of IIEF (p&lt;0.05), and SF-12 (p&lt;0.0001). No adverse events were reported in the study.
DOI: 10.18738/t8/uoes4s/s9dvfy
title: Vid2RealPhase2_P27_kinect_000074.png
DOI: 10.18738/t8/uoes4s/nwd4nd
title: Vid2RealPhase2_P27_kinect_000019.png
DOI: 10.18738/t8/uoes4s/5qhsir
title: Vid2RealPhase2_P27_kinect_000065.png
DOI: 10.57967/hf/3226
title: HWR200
DOI: 10.18738/t8/uoes4s/iu5dur
title: Vid2RealPhase2_P27_kinect_000062.png
DOI: 10.18738/t8/uoes4s/z47ycp
title: Vid2RealPhase2_P27_kinect_000010.png
DOI: 10.18738/t8/uoes4s/olullc
title: Vid2RealPhase2_P27_kinect_000017.png
DOI: 10.18738/t8/uoes4s/0xxsvx
title: Vid2RealPhase2_P27_kinect_000022.png
DOI: 10.18738/t8/uoes4s/alp5cy
title: Vid2RealPhase2_P27_kinect_000059.png
DOI: 10.18738/t8/uoes4s/peivzl
title: Vid2RealPhase2_P27_kinect_000025.png
DOI: 10.18738/t8/uoes4s/rvnvi9
title: Vid2RealPhase2_P27_kinect_000057.png
DOI: 10.18738/t8/uoes4s/yhpobj
title: Vid2RealPhase2_P27_kinect_000050.png
DOI: 10.18738/t8/uoes4s/kraayp
title: Vid2RealPhase2_P27_kinect_000009.png
DOI: 10.18738/t8/uoes4s/oncs2d
title: Vid2RealPhase2_P27_kinect_000075.png
DOI: 10.18738/t8/uoes4s/zlbpq2
title: Vid2RealPhase2_P27_kinect_000072.png
DOI: 10.18738/t8/uoes4s/5zap7q
title: Vid2RealPhase2_P27_kinect_000000.png
DOI: 10.18738/t8/uoes4s/twbzdl
title: Vid2RealPhase2_P27_kinect_000007.png
DOI: 10.18738/t8/uoes4s/skjcwk
title: Vid2RealPhase2_P27_kinect_000032.png
DOI: 10.18738/t8/uoes4s/plazb0
title: Vid2RealPhase2_P27_kinect_000049.png
DOI: 10.18738/t8/uoes4s/teuhgx
title: Vid2RealPhase2_P27_kinect_000035.png
DOI: 10.18738/t8/uoes4s/1yagpq
title: Vid2RealPhase2_P27_kinect_000047.png
DOI: 10.18738/t8/uoes4s/szaqac
title: Vid2RealPhase2_P27_kinect_000040.png
DOI: 10.18738/t8/uoes4s/dy24px
title: Vid2RealPhase2_P27_kinect_000051.png
DOI: 10.18738/t8/uoes4s/hmfb0n
title: Vid2RealPhase2_P27_kinect_000056.png
DOI: 10.18738/t8/uoes4s/cxuobo
title: Vid2RealPhase2_P27_kinect_000058.png
DOI: 10.18738/t8/uoes4s/4szt5p
title: Vid2RealPhase2_P27_kinect_000024.png
DOI: 10.18738/t8/uoes4s/ovzktf
title: Vid2RealPhase2_P27_kinect_000023.png
DOI: 10.18738/t8/uoes4s/agkv9o
title: Vid2RealPhase2_P27_kinect_000016.png
DOI: 10.18738/t8/uoes4s/t2fnmt
title: Vid2RealPhase2_P27_kinect_000011.png
DOI: 10.18738/t8/uoes4s/dosb6v
title: Vid2RealPhase2_P27_kinect_000063.png
DOI: 10.18738/t8/uoes4s/bp3onx
title: Vid2RealPhase2_P27_kinect_000018.png
DOI: 10.18738/t8/uoes4s/ctnfla
title: Vid2RealPhase2_P27_kinect_000064.png
DOI: 10.6084/m9.figshare.26105280
title: Comparative analysis of GMO regulatory requirements for AAV vectors in the EU and Japan focusing on the shedding data and containment measures

description: Recombinant viral-based gene therapy products, such as those incorporating adeno-associated viruses (AAVs), fall under the category of genetically modified organisms (GMOs). The European Union (EU) countries and Japan must obtain environmental risk assessment (ERA) approval for the use of GMOs before starting any clinical trials. It has been reported that the development of GMO-containing products in these two regions encounters several regulatory obstacles due to the longer regulatory procedures and document preparation for ERA. In this article, we comparatively analyzed the ERA document requirements in the EU and Japan for AAV-based recombinant medicinal products to highlight the differences in the context of potential future attempts of convergence. Additionally, we analyzed non-clinical and clinical shedding data requirements, which are key components of ERA reviews in the EU and Japan. Lastly, we compared the containment measures to minimize the spread of GMOs in the environment in the EU and Japan. Based on our comparative analysis, we present several policy recommendations of standardizing and simplifying the application materials and procedures for the ERA regulations on GMOs in the EU and Japan in the mid-, and long-term timeframe to achieve global regulatory convergence.
DOI: 10.6084/m9.figshare.26105280.v2
title: Comparative analysis of GMO regulatory requirements for AAV vectors in the EU and Japan focusing on the shedding data and containment measures

description: Recombinant viral-based gene therapy products, such as those incorporating adeno-associated viruses (AAVs), fall under the category of genetically modified organisms (GMOs). The European Union (EU) countries and Japan must obtain environmental risk assessment (ERA) approval for the use of GMOs before starting any clinical trials. It has been reported that the development of GMO-containing products in these two regions encounters several regulatory obstacles due to the longer regulatory procedures and document preparation for ERA. In this article, we comparatively analyzed the ERA document requirements in the EU and Japan for AAV-based recombinant medicinal products to highlight the differences in the context of potential future attempts of convergence. Additionally, we analyzed non-clinical and clinical shedding data requirements, which are key components of ERA reviews in the EU and Japan. Lastly, we compared the containment measures to minimize the spread of GMOs in the environment in the EU and Japan. Based on our comparative analysis, we present several policy recommendations of standardizing and simplifying the application materials and procedures for the ERA regulations on GMOs in the EU and Japan in the mid-, and long-term timeframe to achieve global regulatory convergence.
DOI: 10.18738/t8/uoes4s/dukl7b
title: Vid2RealPhase2_P27_kinect_000055.png
DOI: 10.18738/t8/uoes4s/7d3fvy
title: Vid2RealPhase2_P27_kinect_000029.png
DOI: 10.18738/t8/uoes4s/ljhjgk
title: Vid2RealPhase2_P27_kinect_000052.png
DOI: 10.18738/t8/uoes4s/n4gxnt
title: Vid2RealPhase2_P27_kinect_000020.png
DOI: 10.18738/t8/uoes4s/sbynon
title: Vid2RealPhase2_P27_kinect_000027.png
DOI: 10.15468/dl.ky9j96
title: Occurrence Download

description: A dataset containing 544 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is China",
 "Month is January",
 "TaxonKey is Tringa erythropus (Pallas, 1764)"
 ]
}

 The dataset includes 544 records from 9 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0005903-241007104925546/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.18738/t8/uoes4s/ukkjnf
title: Vid2RealPhase2_P27_kinect_000012.png
DOI: 10.18738/t8/uoes4s/summmt
title: Vid2RealPhase2_P27_kinect_000015.png
DOI: 10.18738/t8/uoes4s/gorrs9
title: Vid2RealPhase2_P27_kinect_000069.png
DOI: 10.18738/t8/uoes4s/jr7ln0
title: Vid2RealPhase2_P27_kinect_000067.png
DOI: 10.18738/t8/uoes4s/2zxmr4
title: Vid2RealPhase2_P27_kinect_000060.png
DOI: 10.18738/t8/uoes4s/u8zmpv
title: Vid2RealPhase2_P27_kinect_000071.png
DOI: 10.18738/t8/uoes4s/shi1cb
title: Vid2RealPhase2_P27_kinect_000076.png
DOI: 10.18738/t8/uoes4s/tzgrsp
title: Vid2RealPhase2_P27_kinect_000004.png
DOI: 10.18738/t8/uoes4s/27wpdi
title: Vid2RealPhase2_P27_kinect_000003.png
DOI: 10.18738/t8/uoes4s/ozfrtw
title: Vid2RealPhase2_P27_kinect_000036.png
DOI: 10.18738/t8/uoes4s/yvr8zn
title: Vid2RealPhase2_P27_kinect_000031.png
DOI: 10.18738/t8/uoes4s/o98piw
title: Vid2RealPhase2_P27_kinect_000043.png
DOI: 10.18738/t8/uoes4s/tlykdt
title: Vid2RealPhase2_P27_kinect_000044.png
DOI: 10.18738/t8/uoes4s/k9qc0c
title: Vid2RealPhase2_P27_kinect_000038.png
DOI: 10.18738/t8/uoes4s/cyoprn
title: Vid2RealPhase2_P27_kinect_000014.png
DOI: 10.18738/t8/uoes4s/n3uegy
title: Vid2RealPhase2_P27_kinect_000068.png