DOI: 10.5061/dryad.x0k6djhs6
title: Endoscopic and histopathological findings in dyspeptic patients with Helicobacter pylori infection

description: Background: Despite advancements in medicine, gastrointestinal
 diseases caused by Helicobacter pylori continue to be common in developing
 countries. This study analyzed gastric mucosal biopsies from the Manipal
 College of Medical Sciences in Pokhara, Nepal, between January 2017 and
 June 2018 to determine the prevalence of H. pylori, its association with
 histopathological changes, and evaluate it using OLGA and OLGIM systems.
 Methods: In this analytical cross-sectional study, 80 patients
 with dyspepsia were included. Biopsies were collected, stored, and
 labeled. The biopsies were fixed, cut into sections, and stained with
 routine H&E and Giemsa stains. Evaluations were made using OLGA
 and OLGIM staging. Statistical analyses were performed using SPSS version
 17.0, with significance determined at p&lt;0.05.
 Results: Hospital-visiting patients had an 8.41% (38/452)
 [10.97–5.85%, 95% Confidence Interval (CI)] rate of H. pylori infection,
 while dyspeptic patients had 47.50% (38/80) (58.44–36.56, 95% CI). Females
 (48%, 12/25) and patients aged 31–40 (62.50%, 5/8) were mostly affected.
 The most common clinical presentation and endoscopic findings relating
 to infection included weight loss (15.79%) and erythema (44.74%),
 respectively. Provisional and histopathological diagnoses of infected
 patients mostly included gastritis (50%) and chronic gastritis (63.16%),
 respectively. Hundred percent of moderate H. pylori infections
 were associated with normal atrophy and intestinal metaplasia, while
 89.66% of mild infections were associated with mild active and chronic
 inflammation. OLGIM downgraded one OLGA stage 2 and 4 and two OLGA stage 3
 cases. Conclusion: H. pylori infections were most common in
 adults and females with chronic gastritis. OLGIM was less accurate than
 OLGA in evaluating high-risk cases, such as adenocarcinomas.
description: Age, sex, and clinical diagnoses were noted in the patient
 information sheet, which was further entered into Microsoft Excel version
 10.0. The data analysis was conducted using the SPSS
 software, version 17.0. Descriptive statistics were calculated and
 presented in tables and figures. The Chi-Square test was used to determine
 the statistical significance of qualitative variables, with a p-value of
 &lt;0.05 considered significant.
description: # Endoscopic and histopathological findings in dyspeptic patients with
 Helicobacter pylori infection
 The dataset is of
 dyspeptic patients with and without Helicobacter pylori infection. Dataset
 comprises a single sheet. The sheet details for demographic information,
 such as age group and gender of the dyspeptic patients; clinical
 manifestations, including upper gastrointestinal bleeding, abdominal pain,
 anorexia, weight loss; endoscopic findings comprising erythema, ulcer,
 atrophy, growth; provisional endoscopic diagnoses, comprising gastritis,
 benign gastric ulcer, malignancy; histopathological diagnoses, corpus and
 antrum abnormalities, and Operative Link on Gastritis Assessment and
 Operative Link on Gastric Intestinal Metaplasia scoring and staging. Exact
 or direct age is removed and is categorized as age group to anonymize the
 data. Data were anonymized with the code. Patients with dyspepsia were
 coded with alphanumeric number with initial P i.e. Pno. Units of the study
 variables were standard and as follows: (a) Age group Years An oral
 lignocaine spray was administered before the procedure for a local
 anesthetic effect. The surgeon performed gastric mucosal biopsies after
 endoscopic evaluation. Hematoxylin and eosin-stained sections were
 examined under a microscope to identify various gastric mucosal
 histopathological changes. The modified Giemsa stain was utilized to
 examine all sections for the presence of H. pylori. The stained sections
 were graded according to the Updated Sydney System,24 OLGA System, and
 OLGIM System. Except for age, the data were qualitative and were
 calculated as frequency (percentage) in SPSS version 17.0. Quantitative
 variables were calculated as median (interquartile range) and were
 analyzed using t-test for statistical correlations, while qualitative
 variables were calculated as number (percentage) and tested using
 chi-square test at 95% confidence interval. S.N. represents serial number
 of patients, 0 represents female, 1 represents male, OLGA represents
 Operative Link on Gastritis Assessment, and OLGIM represents Operative
 Link on Gastric Intestinal Metaplasia Readers may access the data from the
 Dryad repository or with a request email to the corresponding author,
 Ajaya Basnet (), of the article.