cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.19447562
title: Supplementary Material for: Outcomes of patients undergoing PCI of ostial coronary lesions- A single center study

description: Introduction Ostial coronary lesions are a subset of proximal coronary lesions which are relatively more difficult to treat and were associated with worse clinical outcomes in the early percutaneous coronary intervention (PCI) era. Data regarding the outcomes of ostial lesions' PCI in the contemporary era is lacking. Methods We conducted a single center, all-comer, prospective registry study, enrolling patients undergoing PCI with the use of contemporary drug eluting stents (DES) between July 2016 and February 2018. Included in the present analysis were only patients treated for proximal lesions. Clinical outcomes were compared between patients undergoing PCI of ostial versus proximal non-ostial lesions. The primary endpoint was target vessel revascularization (TVR). Secondary endpoints included Target lesion revascularization (TLR) and major cardiovascular adverse events (MACE) at 12 months. Results A total of 334 (84.7% male, 67.3±10.7 years) patients were included, of which 91 patients were treated for ostial lesions and 243 were treated for proximal non-ostial lesions. Baseline and procedural characteristics were similar between the two groups. At 12 months TVR and TLR were numerically higher among patients undergoing PCI of ostial versus non-ostial lesions without reaching statistical significance (5.5% vs. 3.3%; p=0.35 and 4.4% vs. 2.5%; p=0.47 respectively). The rate of MACE was similar between the two groups. Conclusion In patients undergoing PCI with the use of contemporary DES, clinical outcomes were similar among patients treated for ostial compared to proximal non-ostial lesions. Larger studies are required to further evaluate the performance of contemporary DES in this subset of lesions.
DOI: 10.6084/m9.figshare.19447562.v1
title: Supplementary Material for: Outcomes of patients undergoing PCI of ostial coronary lesions- A single center study

description: Introduction Ostial coronary lesions are a subset of proximal coronary lesions which are relatively more difficult to treat and were associated with worse clinical outcomes in the early percutaneous coronary intervention (PCI) era. Data regarding the outcomes of ostial lesions' PCI in the contemporary era is lacking. Methods We conducted a single center, all-comer, prospective registry study, enrolling patients undergoing PCI with the use of contemporary drug eluting stents (DES) between July 2016 and February 2018. Included in the present analysis were only patients treated for proximal lesions. Clinical outcomes were compared between patients undergoing PCI of ostial versus proximal non-ostial lesions. The primary endpoint was target vessel revascularization (TVR). Secondary endpoints included Target lesion revascularization (TLR) and major cardiovascular adverse events (MACE) at 12 months. Results A total of 334 (84.7% male, 67.3±10.7 years) patients were included, of which 91 patients were treated for ostial lesions and 243 were treated for proximal non-ostial lesions. Baseline and procedural characteristics were similar between the two groups. At 12 months TVR and TLR were numerically higher among patients undergoing PCI of ostial versus non-ostial lesions without reaching statistical significance (5.5% vs. 3.3%; p=0.35 and 4.4% vs. 2.5%; p=0.47 respectively). The rate of MACE was similar between the two groups. Conclusion In patients undergoing PCI with the use of contemporary DES, clinical outcomes were similar among patients treated for ostial compared to proximal non-ostial lesions. Larger studies are required to further evaluate the performance of contemporary DES in this subset of lesions.
DOI: 10.6084/m9.figshare.19447568
title: Supplementary Material for: Outcomes of patients undergoing PCI of ostial coronary lesions- A single center study

description: Introduction Ostial coronary lesions are a subset of proximal coronary lesions which are relatively more difficult to treat and were associated with worse clinical outcomes in the early percutaneous coronary intervention (PCI) era. Data regarding the outcomes of ostial lesions' PCI in the contemporary era is lacking. Methods We conducted a single center, all-comer, prospective registry study, enrolling patients undergoing PCI with the use of contemporary drug eluting stents (DES) between July 2016 and February 2018. Included in the present analysis were only patients treated for proximal lesions. Clinical outcomes were compared between patients undergoing PCI of ostial versus proximal non-ostial lesions. The primary endpoint was target vessel revascularization (TVR). Secondary endpoints included Target lesion revascularization (TLR) and major cardiovascular adverse events (MACE) at 12 months. Results A total of 334 (84.7% male, 67.3±10.7 years) patients were included, of which 91 patients were treated for ostial lesions and 243 were treated for proximal non-ostial lesions. Baseline and procedural characteristics were similar between the two groups. At 12 months TVR and TLR were numerically higher among patients undergoing PCI of ostial versus non-ostial lesions without reaching statistical significance (5.5% vs. 3.3%; p=0.35 and 4.4% vs. 2.5%; p=0.47 respectively). The rate of MACE was similar between the two groups. Conclusion In patients undergoing PCI with the use of contemporary DES, clinical outcomes were similar among patients treated for ostial compared to proximal non-ostial lesions. Larger studies are required to further evaluate the performance of contemporary DES in this subset of lesions.
DOI: 10.6084/m9.figshare.19447568.v1
title: Supplementary Material for: Outcomes of patients undergoing PCI of ostial coronary lesions- A single center study

description: Introduction Ostial coronary lesions are a subset of proximal coronary lesions which are relatively more difficult to treat and were associated with worse clinical outcomes in the early percutaneous coronary intervention (PCI) era. Data regarding the outcomes of ostial lesions' PCI in the contemporary era is lacking. Methods We conducted a single center, all-comer, prospective registry study, enrolling patients undergoing PCI with the use of contemporary drug eluting stents (DES) between July 2016 and February 2018. Included in the present analysis were only patients treated for proximal lesions. Clinical outcomes were compared between patients undergoing PCI of ostial versus proximal non-ostial lesions. The primary endpoint was target vessel revascularization (TVR). Secondary endpoints included Target lesion revascularization (TLR) and major cardiovascular adverse events (MACE) at 12 months. Results A total of 334 (84.7% male, 67.3±10.7 years) patients were included, of which 91 patients were treated for ostial lesions and 243 were treated for proximal non-ostial lesions. Baseline and procedural characteristics were similar between the two groups. At 12 months TVR and TLR were numerically higher among patients undergoing PCI of ostial versus non-ostial lesions without reaching statistical significance (5.5% vs. 3.3%; p=0.35 and 4.4% vs. 2.5%; p=0.47 respectively). The rate of MACE was similar between the two groups. Conclusion In patients undergoing PCI with the use of contemporary DES, clinical outcomes were similar among patients treated for ostial compared to proximal non-ostial lesions. Larger studies are required to further evaluate the performance of contemporary DES in this subset of lesions.
DOI: 10.6084/m9.figshare.19447574
title: Supplementary Material for: Outcomes of patients undergoing PCI of ostial coronary lesions- A single center study

description: Introduction Ostial coronary lesions are a subset of proximal coronary lesions which are relatively more difficult to treat and were associated with worse clinical outcomes in the early percutaneous coronary intervention (PCI) era. Data regarding the outcomes of ostial lesions' PCI in the contemporary era is lacking. Methods We conducted a single center, all-comer, prospective registry study, enrolling patients undergoing PCI with the use of contemporary drug eluting stents (DES) between July 2016 and February 2018. Included in the present analysis were only patients treated for proximal lesions. Clinical outcomes were compared between patients undergoing PCI of ostial versus proximal non-ostial lesions. The primary endpoint was target vessel revascularization (TVR). Secondary endpoints included Target lesion revascularization (TLR) and major cardiovascular adverse events (MACE) at 12 months. Results A total of 334 (84.7% male, 67.3±10.7 years) patients were included, of which 91 patients were treated for ostial lesions and 243 were treated for proximal non-ostial lesions. Baseline and procedural characteristics were similar between the two groups. At 12 months TVR and TLR were numerically higher among patients undergoing PCI of ostial versus non-ostial lesions without reaching statistical significance (5.5% vs. 3.3%; p=0.35 and 4.4% vs. 2.5%; p=0.47 respectively). The rate of MACE was similar between the two groups. Conclusion In patients undergoing PCI with the use of contemporary DES, clinical outcomes were similar among patients treated for ostial compared to proximal non-ostial lesions. Larger studies are required to further evaluate the performance of contemporary DES in this subset of lesions.
DOI: 10.6084/m9.figshare.19447574.v1
title: Supplementary Material for: Outcomes of patients undergoing PCI of ostial coronary lesions- A single center study

description: Introduction Ostial coronary lesions are a subset of proximal coronary lesions which are relatively more difficult to treat and were associated with worse clinical outcomes in the early percutaneous coronary intervention (PCI) era. Data regarding the outcomes of ostial lesions' PCI in the contemporary era is lacking. Methods We conducted a single center, all-comer, prospective registry study, enrolling patients undergoing PCI with the use of contemporary drug eluting stents (DES) between July 2016 and February 2018. Included in the present analysis were only patients treated for proximal lesions. Clinical outcomes were compared between patients undergoing PCI of ostial versus proximal non-ostial lesions. The primary endpoint was target vessel revascularization (TVR). Secondary endpoints included Target lesion revascularization (TLR) and major cardiovascular adverse events (MACE) at 12 months. Results A total of 334 (84.7% male, 67.3±10.7 years) patients were included, of which 91 patients were treated for ostial lesions and 243 were treated for proximal non-ostial lesions. Baseline and procedural characteristics were similar between the two groups. At 12 months TVR and TLR were numerically higher among patients undergoing PCI of ostial versus non-ostial lesions without reaching statistical significance (5.5% vs. 3.3%; p=0.35 and 4.4% vs. 2.5%; p=0.47 respectively). The rate of MACE was similar between the two groups. Conclusion In patients undergoing PCI with the use of contemporary DES, clinical outcomes were similar among patients treated for ostial compared to proximal non-ostial lesions. Larger studies are required to further evaluate the performance of contemporary DES in this subset of lesions.
DOI: 10.7910/dvn/mnwoiz
title: Investigations on Weibo Use and Online Identity

description: Investigations on Weibo usage and online identity
DOI: 10.5281/zenodo.6393821
title: Transcriptome sequencie of female and male adults of Chilo sacchariphagus

description: <strong>Table S1</strong> Primers used for qRT-PCR <strong>Table S2</strong> list of total annotated unigenes. <strong>Table S3</strong> list of male-biased genes. <strong>Table S4</strong> list of female-biased genes. <strong>Table S5</strong> list of transcription factors showed differential expression between male and female. <strong>Table S6</strong> list of sex-determining genes identified in this work.
DOI: 10.5281/zenodo.6393820
title: Transcriptome sequencie of female and male adults of Chilo sacchariphagus

description: <strong>Table S1</strong> Primers used for qRT-PCR <strong>Table S2</strong> list of total annotated unigenes. <strong>Table S3</strong> list of male-biased genes. <strong>Table S4</strong> list of female-biased genes. <strong>Table S5</strong> list of transcription factors showed differential expression between male and female. <strong>Table S6</strong> list of sex-determining genes identified in this work.
DOI: 10.6084/m9.figshare.19447580
title: Supplementary Material for: Outcomes of patients undergoing PCI of ostial coronary lesions- A single center study

description: Introduction Ostial coronary lesions are a subset of proximal coronary lesions which are relatively more difficult to treat and were associated with worse clinical outcomes in the early percutaneous coronary intervention (PCI) era. Data regarding the outcomes of ostial lesions' PCI in the contemporary era is lacking. Methods We conducted a single center, all-comer, prospective registry study, enrolling patients undergoing PCI with the use of contemporary drug eluting stents (DES) between July 2016 and February 2018. Included in the present analysis were only patients treated for proximal lesions. Clinical outcomes were compared between patients undergoing PCI of ostial versus proximal non-ostial lesions. The primary endpoint was target vessel revascularization (TVR). Secondary endpoints included Target lesion revascularization (TLR) and major cardiovascular adverse events (MACE) at 12 months. Results A total of 334 (84.7% male, 67.3±10.7 years) patients were included, of which 91 patients were treated for ostial lesions and 243 were treated for proximal non-ostial lesions. Baseline and procedural characteristics were similar between the two groups. At 12 months TVR and TLR were numerically higher among patients undergoing PCI of ostial versus non-ostial lesions without reaching statistical significance (5.5% vs. 3.3%; p=0.35 and 4.4% vs. 2.5%; p=0.47 respectively). The rate of MACE was similar between the two groups. Conclusion In patients undergoing PCI with the use of contemporary DES, clinical outcomes were similar among patients treated for ostial compared to proximal non-ostial lesions. Larger studies are required to further evaluate the performance of contemporary DES in this subset of lesions.
DOI: 10.6084/m9.figshare.19447580.v1
title: Supplementary Material for: Outcomes of patients undergoing PCI of ostial coronary lesions- A single center study

description: Introduction Ostial coronary lesions are a subset of proximal coronary lesions which are relatively more difficult to treat and were associated with worse clinical outcomes in the early percutaneous coronary intervention (PCI) era. Data regarding the outcomes of ostial lesions' PCI in the contemporary era is lacking. Methods We conducted a single center, all-comer, prospective registry study, enrolling patients undergoing PCI with the use of contemporary drug eluting stents (DES) between July 2016 and February 2018. Included in the present analysis were only patients treated for proximal lesions. Clinical outcomes were compared between patients undergoing PCI of ostial versus proximal non-ostial lesions. The primary endpoint was target vessel revascularization (TVR). Secondary endpoints included Target lesion revascularization (TLR) and major cardiovascular adverse events (MACE) at 12 months. Results A total of 334 (84.7% male, 67.3±10.7 years) patients were included, of which 91 patients were treated for ostial lesions and 243 were treated for proximal non-ostial lesions. Baseline and procedural characteristics were similar between the two groups. At 12 months TVR and TLR were numerically higher among patients undergoing PCI of ostial versus non-ostial lesions without reaching statistical significance (5.5% vs. 3.3%; p=0.35 and 4.4% vs. 2.5%; p=0.47 respectively). The rate of MACE was similar between the two groups. Conclusion In patients undergoing PCI with the use of contemporary DES, clinical outcomes were similar among patients treated for ostial compared to proximal non-ostial lesions. Larger studies are required to further evaluate the performance of contemporary DES in this subset of lesions.
DOI: 10.6084/m9.figshare.19447586
title: Supplementary Material for: Outcomes of patients undergoing PCI of ostial coronary lesions- A single center study

description: Introduction Ostial coronary lesions are a subset of proximal coronary lesions which are relatively more difficult to treat and were associated with worse clinical outcomes in the early percutaneous coronary intervention (PCI) era. Data regarding the outcomes of ostial lesions' PCI in the contemporary era is lacking. Methods We conducted a single center, all-comer, prospective registry study, enrolling patients undergoing PCI with the use of contemporary drug eluting stents (DES) between July 2016 and February 2018. Included in the present analysis were only patients treated for proximal lesions. Clinical outcomes were compared between patients undergoing PCI of ostial versus proximal non-ostial lesions. The primary endpoint was target vessel revascularization (TVR). Secondary endpoints included Target lesion revascularization (TLR) and major cardiovascular adverse events (MACE) at 12 months. Results A total of 334 (84.7% male, 67.3±10.7 years) patients were included, of which 91 patients were treated for ostial lesions and 243 were treated for proximal non-ostial lesions. Baseline and procedural characteristics were similar between the two groups. At 12 months TVR and TLR were numerically higher among patients undergoing PCI of ostial versus non-ostial lesions without reaching statistical significance (5.5% vs. 3.3%; p=0.35 and 4.4% vs. 2.5%; p=0.47 respectively). The rate of MACE was similar between the two groups. Conclusion In patients undergoing PCI with the use of contemporary DES, clinical outcomes were similar among patients treated for ostial compared to proximal non-ostial lesions. Larger studies are required to further evaluate the performance of contemporary DES in this subset of lesions.
DOI: 10.6084/m9.figshare.19176289
title: A novel fluorescent reporter sensitive to serine mis-incorporation

description: High-fidelity translation was considered a requirement for living cells. The frozen accident theory suggested that any deviation from the standard genetic code should result in the production of so much mis-made and non-functional proteins that cells cannot remain viable. Studies in bacterial, yeast, and mammalian cells show that significant levels of mistranslation (1–10% per codon) can be tolerated or even beneficial under conditions of oxidative stress. Single tRNA mutants, which occur naturally in the human population, can lead to amino acid mis-incorporation at a codon or set of codons. The rate or level of mistranslation can be difficult or impossible to measure in live cells. We developed a novel red fluorescent protein reporter that is sensitive to serine (Ser) mis-incorporation at proline (Pro) codons. The mCherry Ser151Pro mutant is efficiently produced in <i>Escherichia coli</i> but non-fluorescent. We demonstrated in cells and with purified mCherry protein that the fluorescence of mCherry Ser151Pro is rescued by two different tRNA<sup>Ser</sup> gene variants that were mutated to contain the Pro (UGG) anticodon. Ser mis-incorporation was confirmed by mass spectrometry. Remarkably, <i>E. coli</i> tolerated mistranslation rates of ~10% per codon with negligible reduction in growth rate. Conformational sampling simulations revealed that the Ser151Pro mutant leads to significant changes in the conformational freedom of the chromophore precursor, which is indicative of a defect in chromophore maturation. Together our data suggest that the mCherry Ser151 mutants may be used to report Ser mis-incorporation at multiple other codons, further expanding the ability to measure mistranslation in living cells.
DOI: 10.6084/m9.figshare.19176289.v1
title: A novel fluorescent reporter sensitive to serine mis-incorporation

description: High-fidelity translation was considered a requirement for living cells. The frozen accident theory suggested that any deviation from the standard genetic code should result in the production of so much mis-made and non-functional proteins that cells cannot remain viable. Studies in bacterial, yeast, and mammalian cells show that significant levels of mistranslation (1–10% per codon) can be tolerated or even beneficial under conditions of oxidative stress. Single tRNA mutants, which occur naturally in the human population, can lead to amino acid mis-incorporation at a codon or set of codons. The rate or level of mistranslation can be difficult or impossible to measure in live cells. We developed a novel red fluorescent protein reporter that is sensitive to serine (Ser) mis-incorporation at proline (Pro) codons. The mCherry Ser151Pro mutant is efficiently produced in <i>Escherichia coli</i> but non-fluorescent. We demonstrated in cells and with purified mCherry protein that the fluorescence of mCherry Ser151Pro is rescued by two different tRNA<sup>Ser</sup> gene variants that were mutated to contain the Pro (UGG) anticodon. Ser mis-incorporation was confirmed by mass spectrometry. Remarkably, <i>E. coli</i> tolerated mistranslation rates of ~10% per codon with negligible reduction in growth rate. Conformational sampling simulations revealed that the Ser151Pro mutant leads to significant changes in the conformational freedom of the chromophore precursor, which is indicative of a defect in chromophore maturation. Together our data suggest that the mCherry Ser151 mutants may be used to report Ser mis-incorporation at multiple other codons, further expanding the ability to measure mistranslation in living cells.
DOI: 10.6084/m9.figshare.19447586.v1
title: Supplementary Material for: Outcomes of patients undergoing PCI of ostial coronary lesions- A single center study

description: Introduction Ostial coronary lesions are a subset of proximal coronary lesions which are relatively more difficult to treat and were associated with worse clinical outcomes in the early percutaneous coronary intervention (PCI) era. Data regarding the outcomes of ostial lesions' PCI in the contemporary era is lacking. Methods We conducted a single center, all-comer, prospective registry study, enrolling patients undergoing PCI with the use of contemporary drug eluting stents (DES) between July 2016 and February 2018. Included in the present analysis were only patients treated for proximal lesions. Clinical outcomes were compared between patients undergoing PCI of ostial versus proximal non-ostial lesions. The primary endpoint was target vessel revascularization (TVR). Secondary endpoints included Target lesion revascularization (TLR) and major cardiovascular adverse events (MACE) at 12 months. Results A total of 334 (84.7% male, 67.3±10.7 years) patients were included, of which 91 patients were treated for ostial lesions and 243 were treated for proximal non-ostial lesions. Baseline and procedural characteristics were similar between the two groups. At 12 months TVR and TLR were numerically higher among patients undergoing PCI of ostial versus non-ostial lesions without reaching statistical significance (5.5% vs. 3.3%; p=0.35 and 4.4% vs. 2.5%; p=0.47 respectively). The rate of MACE was similar between the two groups. Conclusion In patients undergoing PCI with the use of contemporary DES, clinical outcomes were similar among patients treated for ostial compared to proximal non-ostial lesions. Larger studies are required to further evaluate the performance of contemporary DES in this subset of lesions.