cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.7594700.v2
title: Clinical Management of High and Very High Risk Patients with Hyperlipidaemia in Central and Eastern Europe: An Observational Study

description: Full copyright for enhanced digital features is owned by <b> </b>Amgen (Europe) GmbH.<br> <strong>Article full text</strong><br> <br> The article associated with this content has been accepted for online publication and is in the final stages of production. The link to the full text will be made available on this page in the next few days. <br> <br> <strong>Provide enhanced digital features for this article</strong><b><br></b> If you are an author of this publication and would like to provide additional enhanced digital features for your article then please contact adisrapidplus@springer.com.<br> <br> The journal offers a range of additional features designed to increase visibility and readership. All features will be thoroughly peer reviewed to ensure the content is of the highest scientific standard and all features are marked as ‘peer reviewed’ to ensure readers are aware that the content has been reviewed to the same level as the articles they are being presented alongside. Moreover, all sponsorship and disclosure information is included to provide complete transparency and adherence to good publication practices. This ensures that however the content is reached the reader has a full understanding of its origin. No fees are charged for hosting additional open access content.<br> <br> Other enhanced features include, but are not limited to:<br> • Videos and animations<br> • Audio abstracts<br> • Audio slides <b> </b>
DOI: 10.7284/133864
title: Gyrocompass data collected during research cruise EN647 using a Sperry MK-37 instrument system onboard the platform RV Endeavor

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/133865
title: Gyrocompass data collected during research cruise EN647 using a Sperry MK-37 instrument system onboard the platform RV Endeavor

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7594538
title: Conservation and historical distribution of two bumblebee species from the Atlantic Forest

description: In this study, we analysed the processes resulting in the origin of two endemic sister species of bumblebees in the Brazilian Atlantic Forest. We studied the historical distribution pattern of <i>Bombus bahiensis</i>, which is restricted to small fragments in eastern Brazil and the phylogeographic pattern and historical demography of <i>B. brasiliensis</i>, which is widely distributed in southern and south-eastern Brazil and neighbouring regions of Uruguay, Paraguay, and Argentina. We used ecological niche models, niche analyses, and genetic and distribution data (i) to test the role of niche differentiation on the divergence between the two species, (ii) to find potential distribution areas for the most restricted <i>B. bahiensis</i>, and (iii) to evaluate the conservation status of both species. Our results showed that <i>B. brasiliensis</i> populations are able to disperse across mosaics of anthropogenic and preserved areas and exhibit low levels of spatial genetic structure. Otherwise, <i>B. bahiensis</i> presented a restricted distribution range and likely a lower diversity, where it is suffering with an increasing habitat loss. The climatic oscillations of the Pleistocene influenced the population structure of both species in different ways, probably due to differences in their effective population sizes, physiology and past demographic fluctuations. Specifically, while <i>B. brasiliensis</i> expanded its distribution range in the last 500, 000 years throughout most of the Atlantic Forest, <i>B. bahiensis</i> remained restricted to a small rainforest area between southern Bahia and northern Espírito Santo states in Brazil. In its southern distribution, in the state of Espírito Santo, <i>B. bahiensis</i> is currently very rare or extinct. Currently, the adjacent ranges of <i>Bombus brasiliensis</i> and <i>B. bahiensis</i> do not overlap and our results indicate that these species may have further diversified through a reinforcement process associated to niche specialization and differentiation.
DOI: 10.6084/m9.figshare.7594538.v1
title: Conservation and historical distribution of two bumblebee species from the Atlantic Forest

description: In this study, we analysed the processes resulting in the origin of two endemic sister species of bumblebees in the Brazilian Atlantic Forest. We studied the historical distribution pattern of <i>Bombus bahiensis</i>, which is restricted to small fragments in eastern Brazil and the phylogeographic pattern and historical demography of <i>B. brasiliensis</i>, which is widely distributed in southern and south-eastern Brazil and neighbouring regions of Uruguay, Paraguay, and Argentina. We used ecological niche models, niche analyses, and genetic and distribution data (i) to test the role of niche differentiation on the divergence between the two species, (ii) to find potential distribution areas for the most restricted <i>B. bahiensis</i>, and (iii) to evaluate the conservation status of both species. Our results showed that <i>B. brasiliensis</i> populations are able to disperse across mosaics of anthropogenic and preserved areas and exhibit low levels of spatial genetic structure. Otherwise, <i>B. bahiensis</i> presented a restricted distribution range and likely a lower diversity, where it is suffering with an increasing habitat loss. The climatic oscillations of the Pleistocene influenced the population structure of both species in different ways, probably due to differences in their effective population sizes, physiology and past demographic fluctuations. Specifically, while <i>B. brasiliensis</i> expanded its distribution range in the last 500, 000 years throughout most of the Atlantic Forest, <i>B. bahiensis</i> remained restricted to a small rainforest area between southern Bahia and northern Espírito Santo states in Brazil. In its southern distribution, in the state of Espírito Santo, <i>B. bahiensis</i> is currently very rare or extinct. Currently, the adjacent ranges of <i>Bombus brasiliensis</i> and <i>B. bahiensis</i> do not overlap and our results indicate that these species may have further diversified through a reinforcement process associated to niche specialization and differentiation.
DOI: 10.6084/m9.figshare.7594571.v3
title: High-throughput Discovery of Topologically Non-trivial Materials using Spin-orbit Spillage

description: We present a novel methodology to identify topologically non-trivial materials based on band inversion induced by spin-orbit coupling (SOC) effect. Specifically, we compare the density functional theory (DFT) based wavefunctions with and without spin-orbit coupling and compute the ‘spin-orbit-spillage’ as a measure of band-inversion. Due to its ease of calculation, without any need for symmetry analysis or dense k-point interpolation, the spillage is an excellent tool for identifying topologically non-trivial materials. Out of 30000 materials available in the JARVIS-DFT database, we applied this methodology to more than 4835 non-magnetic materials consisting of heavy atoms and low bandgaps. We found 1868 candidate materials with high-spillage (using 0.5 as a threshold). We validated our methodology by carrying out conventional Wannier-interpolation calculations for 289 candidate materials. We demonstrate that in addition to Z<sub>2</sub> topological insulators, this screening method successfully identified many semimetals and topological crystalline insulators. Importantly, our approach is applicable to the investigation of disordered or distorted as well as magnetic materials, because it is not based on symmetry considerations. We discuss some individual example materials, as well as trends throughout our dataset, which is available at the websites: https://www.ctcms.nist.gov/~knc6/JVASP.html and https://jarvis.nist.gov/.
DOI: 10.7284/133869
title: Meteorological Station data collected during research cruise EN647 using a RM Young 26800 instrument system onboard the platform RV Endeavor

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7594433
title: Unobtrusive Mattress-based Identification of Hypertension by Integrating Classification and Association Rule Mining

description: It contans 128 BCG recordings (61 hypertensive and 67 normotensive), and the software code of association classifier.
DOI: 10.6084/m9.figshare.7594571.v2
title: High-throughput discovery of topological materials using spin-orbit spillage

description: We present the results of a high-throughput, first principles search for topological materials based on identifying materials with band inversion induced by spin-orbit coupling. Out of the currently available 30000 materials in our database, we investigate more than 4835 non-magnetic materials having heavy atoms and low bandgaps. We compute the spillage between the spin-orbit and non-spin-orbit wave functions, resulting in more than 1868 high-spillage candidate materials. We demonstrate that in addition to Z<sub>2</sub> topological insulators, this screening method successfully identifies many semimetals and topological crystalline insulators. Our approach is applicable to the investigation of disordered or distorted as well as magnetic materials, because it is not based on symmetry considerations. After our first screening step, we use Wannier-interpolation to calculate the topological invariants and to search for band crossings. We discuss some individual example materials, as well as trends throughout our dataset, available at the JARVIS-DFT website: https://jarvis.nist.gov/.
DOI: 10.7284/133866
title: Radiometer data collected during research cruise EN647 using a Eppley RAD instrument system onboard the platform RV Endeavor

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/133867
title: Radiometer data collected during research cruise EN647 using a Eppley RAD instrument system onboard the platform RV Endeavor

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7594343
title: Physiological, developmental, and life-history traits datasets

description: Multiple physiological, developmental, and life-history traits measurements in Drosophila melanogaster flies reared under various diet conditions, treated or not with antibiotics in order to alter gut microbiota.
DOI: 10.6084/m9.figshare.7594433.v1
title: Unobtrusive Mattress-based Identification of Hypertension by Integrating Classification and Association Rule Mining

description: It contans 128 BCG recordings (61 hypertensive and 67 normotensive), and the software code of association classifier.
DOI: 10.6084/m9.figshare.7594343.v1
title: Physiological, developmental, and life-history traits datasets

description: Multiple physiological, developmental, and life-history traits measurements in Drosophila melanogaster flies reared under various diet conditions, treated or not in order to remove gut microbiota.
DOI: 10.7284/133875
title: Singlebeam Echosounder data collected during research cruise EN647 using a Knudsen 320B/R instrument system onboard the platform RV Endeavor

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7594265
title: Supplementary Material for: DNA Methylation of the Leptin Gene Promoter is Altered by Chronic Alcohol Exposure in an Animal Model for Alcohol Dependence

description: Appetite-regulating peptides, such as leptin, are linked to craving and have been in the focus of alcohol dependence research for years. The objective of our study was to investigate the dynamics of leptin gene promoter methylation during alcohol withdrawal and specific treatment in a rodent (rat) model for alcohol dependence. DNA methylation was measured using direct bisulfite sequencing at 0 h, 24 h, and 6 days of alcohol withdrawal as well as after treatment with alpha-melanocyte-stimulating hormone (alpha-MSH), Beta-Endorphin, or saline. We found significantly lower methylation levels in alcohol-consuming animals compared to alcohol-naïve animals. During 6 days of alcohol deprivation, this difference in methylation vanished. Leptin methylation of the alpha-MSH-treated group and 6 days alcohol-deprived animals was significantly higher than that in saline-treated animals, possibly indicating compensatory effects of the treatment. Our results further expand on previous findings from human studies that explain leptin’s role in bridging the gap between alcohol consumption and appetite regulation.
DOI: 10.6084/m9.figshare.7594265.v1
title: Supplementary Material for: DNA Methylation of the Leptin Gene Promoter is Altered by Chronic Alcohol Exposure in an Animal Model for Alcohol Dependence

description: Appetite-regulating peptides, such as leptin, are linked to craving and have been in the focus of alcohol dependence research for years. The objective of our study was to investigate the dynamics of leptin gene promoter methylation during alcohol withdrawal and specific treatment in a rodent (rat) model for alcohol dependence. DNA methylation was measured using direct bisulfite sequencing at 0 h, 24 h, and 6 days of alcohol withdrawal as well as after treatment with alpha-melanocyte-stimulating hormone (alpha-MSH), Beta-Endorphin, or saline. We found significantly lower methylation levels in alcohol-consuming animals compared to alcohol-naïve animals. During 6 days of alcohol deprivation, this difference in methylation vanished. Leptin methylation of the alpha-MSH-treated group and 6 days alcohol-deprived animals was significantly higher than that in saline-treated animals, possibly indicating compensatory effects of the treatment. Our results further expand on previous findings from human studies that explain leptin’s role in bridging the gap between alcohol consumption and appetite regulation.
DOI: 10.6084/m9.figshare.7594232
title: EmBeD data

description: <b>EmBeD</b>,<i> Energy-based anomaly detector in the cloud</i>, is an approach to detect anomalies at runtime based on the free energy of a Restricted Boltzmann Machine (RBM) model. The free energy is a stochastic function that can be used to efficiently score anomalies for detecting outliers. EmBeD analyzes the system behavior from raw metric data, does not require extensive training with seeded faults, and classifies the relation of anomalous behaviors with future failures with very few false positives. The file data.zip contains the dataset used for validating <i>EmBeD</i>.
DOI: 10.6084/m9.figshare.7594262
title: Le Bagousse-Pinguet et al. 2019_PNAS_Phylogenetic supertree

description: Phylogenetic supertree used in the present study.<br>
DOI: 10.7284/133872
title: Speedlog data collected during research cruise EN647 using a Furuno DS-50 instrument system onboard the platform RV Endeavor

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/133874
title: Timeserver data collected during research cruise EN647 using a Spectracom SecureSync instrument system onboard the platform RV Endeavor

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.25376/hra.7594124
title: Brach_CE-1304-6301_FRR_CE.pdf

description: <b>Objectives: </b>To compare the effectiveness and sustainability of <i>On the Move</i> against a Standard group exercise program consisting of seated strength, endurance, and flexibility exercises in community-dwelling older adults who reside in independent living facilities and senior apartment buildings, and who live elsewhere but regularly attend senior community centers. <b>Methods:</b> The study was a cluster randomized, single-blind intervention trial that compared the effects on function, disability, and mobility of a Standard group exercise program and the <i>On the Move</i> group exercise program in community-dwelling older adults. Thirty-two facilities were randomized, encompassing 424 individuals. <b>Results:</b> The mean ± standard deviation age of the participants was 80.7 ± 7.8 years. The <i>On the Move</i> group had greater improvements than the Standard group in the primary measures of mobility, the 6MWT (20.6 ± 57.1 versus 4.1 ± 55.6 m; adjusted difference = 16.7 ± 7.4; <i>p</i> = 0.0262), and gait speed (0.05 ± 0.13 versus –0.01 ± 0.11 m/s; adjusted difference = 0.05 ± 0.02; <i>p</i> = 0.0008). The between-group differences were adjusted for the baseline value of the outcome and represent a small but meaningful difference. There were no significant differences in self-reported function and disability as measured by the LLFDI scores. <b>Conclusions:</b> When taught by exercise leaders, the <i>On the Move</i> group exercise program was more effective at improving mobility than the Standard group exercise program, more safe, and well-liked by community-dwelling older adults.
DOI: 10.6084/m9.figshare.7594154
title: <i>In vitro</i> anti-inflammatory and free radical scavenging properties of <i>Oldenlandia auricularia</i>

description: The <i>in vitro</i> anti-inflammatory and antioxidant properties of extract of <i>Oldenlandia auricularia with</i> 70% aqueous alcohol have been evaluated. The inhibition of nuclear translocation of nuclear factor kappa-light-chain-enhancer of activated B cells in lipopolysaccharide stimulated murine macrophage cells was evaluated. Messenger ribonucleic acid levels of tumor necrosis factor-α and cyclooxygenase-2 were analysed by quantitative real time polymerase chain reaction. <i>O. auricularia</i> (100 mg/L) showed better anti-inflammatory and antioxidant activities when compared to its lower doses, whereas the standard drugs curcumin and diclofenac sodium showed significant anti-inflammatory and antioxidant potential. Treatment at this concentration inhibited the signalling pathway of nuclear factor kappa-light-chain-enhancer of activated B cells and messenger ribonucleic acid expression of tumor necrosis factor- α, and cyclooxygenase-2. Liquid chromatography/quadrupole time-of-flight mass spectrometry revealed the presence of previously reported compounds auricularine, ursolic acid and β-sitosterol. The observed anti-inflammatory property of <i>O. auricularia</i> could be due to the inhibition of nuclear factor kappa-light-chain-enhancer of activated B cells p65 sub unit nuclear translocation and inhibition of its signalling pathway.
DOI: 10.6084/m9.figshare.7594154.v1
title: <i>In vitro</i> anti-inflammatory and free radical scavenging properties of <i>Oldenlandia auricularia</i>

description: The <i>in vitro</i> anti-inflammatory and antioxidant properties of extract of <i>Oldenlandia auricularia with</i> 70% aqueous alcohol have been evaluated. The inhibition of nuclear translocation of nuclear factor kappa-light-chain-enhancer of activated B cells in lipopolysaccharide stimulated murine macrophage cells was evaluated. Messenger ribonucleic acid levels of tumor necrosis factor-α and cyclooxygenase-2 were analysed by quantitative real time polymerase chain reaction. <i>O. auricularia</i> (100 mg/L) showed better anti-inflammatory and antioxidant activities when compared to its lower doses, whereas the standard drugs curcumin and diclofenac sodium showed significant anti-inflammatory and antioxidant potential. Treatment at this concentration inhibited the signalling pathway of nuclear factor kappa-light-chain-enhancer of activated B cells and messenger ribonucleic acid expression of tumor necrosis factor- α, and cyclooxygenase-2. Liquid chromatography/quadrupole time-of-flight mass spectrometry revealed the presence of previously reported compounds auricularine, ursolic acid and β-sitosterol. The observed anti-inflammatory property of <i>O. auricularia</i> could be due to the inhibition of nuclear factor kappa-light-chain-enhancer of activated B cells p65 sub unit nuclear translocation and inhibition of its signalling pathway.
DOI: 10.6084/m9.figshare.7594115
title: Transparency and credibility of industry-sponsored clinical trial publications: a survey of journal editors

description: <b>Objective:</b> To examine how medical journal editors perceive changes in transparency and credibility of industry-sponsored clinical trial publications over a 5 year period (2010 to 2015). <b>Methods:</b> From July to September 2015, a survey link was emailed to journal editors identified from the Thomson Reuters registry. Editors ranked their perception of: a) change in transparency and credibility of industry-sponsored clinical trial publications; b) 8 “Publication Best Practices” and the impact of each on transparency; and c) the importance and adoption of the previously published “10 Recommendations for Closing the Credibility Gap in Reporting Industry-Sponsored Clinical Research”. <b>Results:</b> Of 510 editors who opened the survey, the analysis pool comprised a total of 293 editors. The majority of respondents reported their location as the US (46%) or EU (45%) and most commonly reported editorial titles were deputy/assistant editor (36%), editor-in-chief (35%) and section editor (24%). More editors reported improved versus worsened transparency (63.5% vs. 6.1%) and credibility (53.2% vs. 10.4%). Best practices that contributed most to improved transparency were “disclosure of the study sponsor” and “registration and posting of trial results”. Respondents ranked the importance of nine recommendations as moderate or extremely important, and adoption of all recommendations was ranked minimal to moderate. <b>Conclusions:</b> The 293 editors who responded perceived an improvement in the transparency and credibility of industry-sponsored publications from 2010 to 2015. Confirmation of the importance of 9/10 recommendations by the respondents was encouraging. Yet, low adoption rates suggest that additional work is required by all stakeholders to improve best practices, transparency and credibility.
DOI: 10.6084/m9.figshare.7594232.v1
title: EmBeD data

description: <b>EmBeD</b>,<i> Energy-based anomaly detector in the cloud</i>, is an approach to detect anomalies at runtime based on the free energy of a Restricted Boltzmann Machine (RBM) model. The free energy is a stochastic function that can be used to efficiently score anomalies for detecting outliers. EmBeD analyzes the system behavior from raw metric data, does not require extensive training with seeded faults, and classifies the relation of anomalous behaviors with future failures with very few false positives.The file data.zip contains the dataset used for validating <i>EmBeD</i>.<br>
DOI: 10.7284/133868
title: TSG (Thermosalinograph) data collected during research cruise EN647 using a Sea-Bird SBE-45 instrument system onboard the platform RV Endeavor

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7594232.v3
title: EmBeD data

description: <b>EmBeD</b>,<i> Energy-based anomaly detector in the cloud</i>, is an approach to detect anomalies at runtime based on the free energy of a Restricted Boltzmann Machine (RBM) model. The free energy is a stochastic function that can be used to efficiently score anomalies for detecting outliers. EmBeD analyzes the system behavior from raw metric data, does not require extensive training with seeded faults, and classifies the relation of anomalous behaviors with future failures with very few false positives. The file data.zip contains the dataset used for validating <i>EmBeD</i>.