cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.4121/21407700.v1
title: Data underlying the publication: Unraveling the Nature of Extraframework Catalytic Ensembles in Zeolites: Flexibility and Dynamics of the Copper-Oxo Trimers in Mordenite

description: This dataset contains the information from the paper: "Unraveling the Nature of Extraframework Catalytic Ensembles in Zeolites: Flexibility and Dynamics of the Copper-Oxo Trimers in Mordenite". It includes the trajectories generated in this study and their post-processing procedures (python scripts and excel data sheets). Moreover, this dataset contains data on energy profiles for methane activation process.
DOI: 10.4121/21400845.v1
title: Data underlying the publication: Global optimization of extraframework ensembles in zeolites: on the structure of extra-framework aluminum species in MOR and MFI zeolites.

description: This dataset contains detailed information on the structures studied in the following paper: "Global optimization of extraframework ensembles in zeolites: on the structure of extra-framework aluminium species in MOR and MFI zeolites". Our data include the computational results of the genetic algorithm runs conducted for each configuration and figures presented in the manuscript.
DOI: 10.4121/21400845
title: Data underlying the publication: Global optimization of extraframework ensembles in zeolites: on the structure of extra-framework aluminum species in MOR and MFI zeolites.

description: This dataset contains detailed information on the structures studied in the following paper: "Global optimization of extraframework ensembles in zeolites: on the structure of extra-framework aluminium species in MOR and MFI zeolites". Our data include the computational results of the genetic algorithm runs conducted for each configuration and figures presented in the manuscript.
DOI: 10.4121/21401148.v1
title: Data underlying the publication: "Regulation of piglet T-cell immune responses by thioredoxin peroxidase from Cysticercus cellulosae excretory-secretory antigens"

description: This dataset contains data collected in in vitro experiments on pigs conducted at Zunyi Medical University as part of Wei He's (first author of the manuscript) master's thesis project. The purpose of this study was toexplore the effect of thioredoxin peroxidase (TPx) protein on piglet T-cell immune responses in vitro, which was mainly identified by flow cytometry and ELISA. This dataset contains raw data, unmodified raw images, as well as data analysis and the production of statistical graphs through Flowjo, SPSS and Graphad Prism.
DOI: 10.4121/21395163.v1
title: I.AM. archive containing box-toss experiments with Box005 for sensitivity analysis

description: I.AM. archive as part of the Impact-Aware Robotics Archives Collection. This archive contains recordings of experiments that are executed under the scenario of TOSS. In these recordings, a UR10 robot is used to toss Box005 on a stationary and a moving conveyor belt, where the box is picked up from different pick-up positions. The purpose of these experiments is to perform a sensitivity analysis of tossing boxes as part of the modeling framework to assess how sensitive the rest-pose of the box is to varying pick-up positions. This modeling framework is used within the H2020 I.AM. project (www.i-am-project.eu) to predict the end pose of a certain box on a conveyor belt, after it is tossed. The involved contact is between the object and the environment, which in these recordings are Box005 and a conveyor, respectively. All the recordings in the archive were performed at the Innovation Lab of Vanderlande, located within the TU/e campus. More information can be found on https://impact-aware-robotics-database.tue.nl/.
DOI: 10.4121/21401148
title: Data underlying the publication: "Regulation of piglet T-cell immune responses by thioredoxin peroxidase from Cysticercus cellulosae excretory-secretory antigens"

description: This dataset contains data collected in in vitro experiments on pigs conducted at Zunyi Medical University as part of Wei He's (first author of the manuscript) master's thesis project. The purpose of this study was toexplore the effect of thioredoxin peroxidase (TPx) protein on piglet T-cell immune responses in vitro, which was mainly identified by flow cytometry and ELISA. This dataset contains raw data, unmodified raw images, as well as data analysis and the production of statistical graphs through Flowjo, SPSS and Graphad Prism.
DOI: 10.4121/21395163
title: I.AM. archive containing box-toss experiments with Box005 for sensitivity analysis

description: I.AM. archive as part of the Impact-Aware Robotics Archives Collection. This archive contains recordings of experiments that are executed under the scenario of TOSS. In these recordings, a UR10 robot is used to toss Box005 on a stationary and a moving conveyor belt, where the box is picked up from different pick-up positions. The purpose of these experiments is to perform a sensitivity analysis of tossing boxes as part of the modeling framework to assess how sensitive the rest-pose of the box is to varying pick-up positions. This modeling framework is used within the H2020 I.AM. project (www.i-am-project.eu) to predict the end pose of a certain box on a conveyor belt, after it is tossed. The involved contact is between the object and the environment, which in these recordings are Box005 and a conveyor, respectively. All the recordings in the archive were performed at the Innovation Lab of Vanderlande, located within the TU/e campus. More information can be found on https://impact-aware-robotics-database.tue.nl/.
DOI: 10.4121/21399879.v1
title: Archive containing experiments with a drone impacting a rigid wall with the purpose of parameter identification

description: Archive as part of the Impact-Aware Robotics Archives Collection. This archive contains recordings of experiments where a drone (CrazyFlie001) is crashed into a rigid wall (ImpactPlane001). In these recordings, CrazyFlie001 slides down from a slide, enters free flight, and then crashes into a wall. The purpose of these experiments is to perform velocity based parameter identification of the contact parameters in a nonsmooth modeling framework. The involved contact is between the object and the environment, which in these recordings are a drone (CrazyFlie001) and a rigid wall (ImpactPlane001), respectively. All the recordings in the archive were performed at the Robotics field of the Robotics Lab, located in the Impuls building at the TU/e campus. More information about the dataset, the objects, and the environments used, can be found on https://impact-aware-robotics-database.tue.nl/.
DOI: 10.4121/21399879
title: Archive containing experiments with a drone impacting a rigid wall with the purpose of parameter identification

description: Archive as part of the Impact-Aware Robotics Archives Collection. This archive contains recordings of experiments where a drone (CrazyFlie001) is crashed into a rigid wall (ImpactPlane001). In these recordings, CrazyFlie001 slides down from a slide, enters free flight, and then crashes into a wall. The purpose of these experiments is to perform velocity based parameter identification of the contact parameters in a nonsmooth modeling framework. The involved contact is between the object and the environment, which in these recordings are a drone (CrazyFlie001) and a rigid wall (ImpactPlane001), respectively. All the recordings in the archive were performed at the Robotics field of the Robotics Lab, located in the Impuls building at the TU/e campus. More information about the dataset, the objects, and the environments used, can be found on https://impact-aware-robotics-database.tue.nl/.
DOI: 10.4121/21387606.v1
title: I.AM. archive containing box-toss experiments with Box005 for repeatability analysis

description: I.AM. archive as part of the Impact-Aware Robotics Archives Collection. This archive contains recordings of experiments that are executed under the scenario of TOSS. In these recordings, a UR10 robot is used to toss and Box005 on a stationary and a moving conveyor belt. The purpose of these experiments is perform a repeatability analysis of tossing boxes as part of the modeling framework. This modeling framework is used within the H2020 I.AM. project (www.i-am-project.eu) to predict the end pose of a certain box on a conveyor belt, after it is tossed. This means that the involved contact is between the object and the environment, which in these recordings are Box005 and a conveyor, respectively. All the recordings in the archive were performed at the Innovation Lab of Vanderlande, located within the TU/e campus. More information can be found on https://impact-aware-robotics-database.tue.nl/.
DOI: 10.4121/21387606
title: I.AM. archive containing box-toss experiments with Box005 for repeatability analysis

description: I.AM. archive as part of the Impact-Aware Robotics Archives Collection. This archive contains recordings of experiments that are executed under the scenario of TOSS. In these recordings, a UR10 robot is used to toss and Box005 on a stationary and a moving conveyor belt. The purpose of these experiments is perform a repeatability analysis of tossing boxes as part of the modeling framework. This modeling framework is used within the H2020 I.AM. project (www.i-am-project.eu) to predict the end pose of a certain box on a conveyor belt, after it is tossed. This means that the involved contact is between the object and the environment, which in these recordings are Box005 and a conveyor, respectively. All the recordings in the archive were performed at the Innovation Lab of Vanderlande, located within the TU/e campus. More information can be found on https://impact-aware-robotics-database.tue.nl/.
DOI: 10.6084/m9.figshare.19740273
title: Reversal of temperature responses to methylone mediated through bi-directional fecal microbiota transplantation between hyperthermic tolerant and naïve rats

description: The synthetic cathinone (“bath salt”) methylone induces a hyperthermia response and with chronic administration tolerance to this hyperthermia has been reported. The microbiome-gut-brain axis has been implicated in multiple bodily systems and pathologies, and intentional manipulation of the gut-microbiome has yielded clinically significant results. Here, we examined the effects of bi-directional Fecal Microbiota Transplantation (FMT) between methylone-induced hyperthermic tolerant (MHT) and methylone-naïve (MN) rats. Rats treated with methylone once per week developed tolerance to methylone-induced hyperthermia by the fourth week. Once tolerant, daily bi-directional FMT between the two groups were performed for seven days prior to the next methylone treatment. The FMT abated the developed tolerance in the MHT group. When treated with methylone for the first time following FMT, recipient MN rats displayed significant tolerance to hyperthermia despite it being their initial drug treatment. Post-FMT, MHT rats displayed elevations in norepinephrine and expression of <i>UCP1, UCP3</i> and <i>TGR5</i> in brown adipose tissue, with reductions in expression of <i>TGR5</i> and <i>UCP3</i> in skeletal muscle. The pre- and post-FMT methylone tolerance phenotypes of transplant recipients are concurrent with changes in the relative abundance of several classes of Proteobacteria, most evident for Gammaproteobacteria and Alphaproteobacteria. MHT recipients demonstrated a marked increase in the relative proportion of the Firmicutes class Erysipelotrichia. These findings suggest that transplantation of gut-microbiomes can confer phenotypic responses to a drug and that the microbiome may be playing a major role in sympathomimetic-mediated hyperthermia. <b>Abbreviations:</b> 3,4-methylenedioxymethamphetamine (MDMA); methylone-induced hyperthermic tolerant (MHT); methylone-naïve (MN); fecal microbiota transplantation (FMT); uncoupling protein (UCP); subcutaneous (sc); intraperitoneal (ip); brown adipose tissue (BAT); skeletal muscle (SKM); sympathetic nervous system (SNS); norepinephrine (NE); quantitative PCR (qRT-PCR); quantification cycle (Cq); High Performance Liquid Chromatography-Electrochemical Detection (HPLC-EC); amplicon sequence variants (ASVs); principal coordinates analysis (PCoA); permutational multivariate analysis (PERMANOVA)
DOI: 10.6084/m9.figshare.19740273.v1
title: Reversal of temperature responses to methylone mediated through bi-directional fecal microbiota transplantation between hyperthermic tolerant and naïve rats

description: The synthetic cathinone (“bath salt”) methylone induces a hyperthermia response and with chronic administration tolerance to this hyperthermia has been reported. The microbiome-gut-brain axis has been implicated in multiple bodily systems and pathologies, and intentional manipulation of the gut-microbiome has yielded clinically significant results. Here, we examined the effects of bi-directional Fecal Microbiota Transplantation (FMT) between methylone-induced hyperthermic tolerant (MHT) and methylone-naïve (MN) rats. Rats treated with methylone once per week developed tolerance to methylone-induced hyperthermia by the fourth week. Once tolerant, daily bi-directional FMT between the two groups were performed for seven days prior to the next methylone treatment. The FMT abated the developed tolerance in the MHT group. When treated with methylone for the first time following FMT, recipient MN rats displayed significant tolerance to hyperthermia despite it being their initial drug treatment. Post-FMT, MHT rats displayed elevations in norepinephrine and expression of <i>UCP1, UCP3</i> and <i>TGR5</i> in brown adipose tissue, with reductions in expression of <i>TGR5</i> and <i>UCP3</i> in skeletal muscle. The pre- and post-FMT methylone tolerance phenotypes of transplant recipients are concurrent with changes in the relative abundance of several classes of Proteobacteria, most evident for Gammaproteobacteria and Alphaproteobacteria. MHT recipients demonstrated a marked increase in the relative proportion of the Firmicutes class Erysipelotrichia. These findings suggest that transplantation of gut-microbiomes can confer phenotypic responses to a drug and that the microbiome may be playing a major role in sympathomimetic-mediated hyperthermia. <b>Abbreviations:</b> 3,4-methylenedioxymethamphetamine (MDMA); methylone-induced hyperthermic tolerant (MHT); methylone-naïve (MN); fecal microbiota transplantation (FMT); uncoupling protein (UCP); subcutaneous (sc); intraperitoneal (ip); brown adipose tissue (BAT); skeletal muscle (SKM); sympathetic nervous system (SNS); norepinephrine (NE); quantitative PCR (qRT-PCR); quantification cycle (Cq); High Performance Liquid Chromatography-Electrochemical Detection (HPLC-EC); amplicon sequence variants (ASVs); principal coordinates analysis (PCoA); permutational multivariate analysis (PERMANOVA)
DOI: 10.6084/m9.figshare.21444786
title: Effectiveness of Stabilization Exercise in Youth Basketball Players with and without a History Of Ankle Sprain

description: spss file
DOI: 10.6084/m9.figshare.21444786.v1
title: Effectiveness of Stabilization Exercise in Youth Basketball Players with and without a History Of Ankle Sprain

description: spss file
DOI: 10.6084/m9.figshare.21444756
title: Metadata of Laccase Utilization in Wastewater Treatment from Scopus Database (1978-2022)

description: This is a .CSV file exported from Scopus database.
DOI: 10.48432/zajmpq/m0nynb
title: Sequência Haa1 Komagataella phaffii.docx

description: Sequência gênica do fator de transcrição Haa1 da levedura Komagataella phaffii
DOI: 10.48432/zajmpq
title: Sequência de gene codificador para fator de transcrição que confere tolerância a ácido acético a levedura Komagataella phaffii

description: A superexpressão do fator de transcrição Haa1 aumenta a resistência da levedura Saccharomyces cerevisiae ao ácido acético, um importante ácido carboxílico presente em hidrolisados de biomassa. A superexpressão desse fator de transcrição em outros microrganismos produtores de compostos renováveis a partir de hidrolisados lignocelulósicos pode também favorecer o desempenho fermentativo e a produção dos compostos desejados. Como o gene Haa1 representa um ativo de base biotecnológica, esse conjunto de dados reune a sequência de nucleotídeos do fator de transcrição Haa1 da levedura Komagataella phaffii (sin. Pichia pastoris). Para tanto, a sequência do Haa1 foi identificada, superexpressa e a função validada na levedura. Inicialmente, a sequência proteica de Haa1 foi identificada no genoma da levedura K. phaffii por análises de similaridade com o homólogo de Saccharomyces cerevisiae. Posteriormente, a sequência gênica foi amplificada a partir DNA genômico da levedura e clonada sob controle de dois diferentes promotores constitutivos pGAP e pRPP1b (possui força de cerca de 20% do pGAP). Após transformação da levedura K. phaffii X-33 com os vetores, selecionou-se transformantes por resistência a antibiótico e confirmação da integração do vetor de expressão no genoma da levedura. Finalmente, o desempenho de linhagens recombinantes de K. phaffii superexpressando o fator de transcrição Haa1 foi avaliado na presença de ácido acético e hidrolisado lignocelulósico. A superexpressão de Haa1 conferiu à levedura maior tolerância ao ácido acético entre 4 g/L e 6 g/L reduzindo o tempo de destoxificação em até seis horas e aumentando a produção de biomassa da levedura em até 20%. Os resultados obtidos demonstram a eficiência de K. phaffii Haa1 aumentar a tolerância a ácido acético e abrem caminho para melhorar o desempenho da levedura na produção de compostos renováveis a partir de hidrolisado lignocelulósico.
DOI: 10.23729/bbf3a773-7e76-4c7d-a458-920c4fdeabd7
title: Hungarian Soil preview

description: The samples represent the B accumulation and E eluviation horizons of a Luvisol (brown forest soil) from Hungary. B horizon sample with thin clay accumulation layers, and iron rich coatings, layers. The E horizon does not show these features. Preview of PAS-dataset https://doi.org/10.23729/01909e60-d465-4e07-bace-763ce9f854e1
DOI: 10.48432/yzwvvo/lfucca
title: Sequência proteica para transportador de açúcar.docx

description: Sequência proteica para transportador de açúcares
DOI: 10.48432/yzwvvo
title: Sequência proteica para transportador de açúcares que confere a levedura capacidade de internalizar glicose e xilose simultaneamente

description: A biomassa lignocelulósica é uma matéria-prima renovável para a produção de diversos produtos químicos e combustíveis de alto valor agregado. Em geral, xilose e glicose são os principais açúcares em hidrolisados de biomassa, e sua utilização eficiente por microrganismos é fundamental para um processo de produção econômico. Leveduras capazes de co-consumir açúcares mistos podem levar a maiores rendimentos e produtividades em processos de fermentação industrial. Ensaio de evolução adaptativa com a levedura fermentadora de xilose Spathaspora passalidarum foi realizado para se obter clones derivados com capacidades aprimoradas de co-consumo de glicose e xilose. As cepas adaptadas foram obtidas após seleção de crescimento sucessiva usando xilose e o análogo de glicose não metabolizado 2-desoxi-D-glicose (2-DOG) como pressão seletiva. A capacidade de co-fermentação da linhagem evoluída e parental foi avaliada em açúcares puros e misturas de xilose-glicose. Os resultados revelaram uma melhor capacidade de co-assimilação pela cepa evoluída. O resequenciamento do genoma da cepa evoluída revelou genes afetados por mutações não sinônimas que podem estar envolvidas com o fenótipo de co-consumo, incluindo o gene HXT2.4 que codifica um suposto transportador de glicose em S. passalidarum. Para validar a funcionalidade do HXT2.4 mutante, este e o gene nativo foram expressos na levedura Saccharomyces cerevisiae. Ensaios de crescimento e fermentativo com as leveduras transformadas demonstraram que a expressão do HXT2.4 mutante permitiu a co-assimilação de glicose e xilose pelas células, enquanto o gene nativo transporta somente glicose. Dessa forma, um novo transportador de glicose de S. passalidarum e seu correspondente mutado capaz de transportar glicose e xilose foram identificados. A sequencia do transportador HXT2.4 nativo e as mutações encontradas na versão capaz de fazer o co-transporte de glicose e xilose são disponibilizados.
DOI: 10.25402/cer.21444834
title: Evaluation of emerging NASH therapies: the impact of treatment efficacy profiles on long-term health outcomes: Supplementary materials

description: Aim: Evaluations of nonalcoholic steatohepatitis (NASH) treatments require predicting lifetime outcomes from short-term clinical trials. Materials & methods: A Markov model with NASH fibrosis stages F0– F3, NASH resolution, compensated cirrhosis (F4/CC), and liver-related complication (LRC) states was developed using literature-based standard of care (SoC) data. Hypothetical efficacy profiles were defined affecting resolution (100%-increase), fibrosis improvement (100% increase), or fibrosis worsening (50% decrease). Results: For the SoC, 10-year LRC rates increased with baseline fibrosis stage (F1: 3.0%; F2: 9.8%; F3: 27.2%; F4/CC: 64.9%). The fibrosis worsening profile reduced predicted 10-year LRC rates (F1: 1.9%; F2: 6.5%; F3: 19.1%; F4/CC: 55.0%) more than the resolution and fibrosis improvement profiles (F1: 2.6%/2.6%; F2: 8.5%/8.3%; F3: 23.3%/23.0%; F4/CC: NA/59.0%). Scenario analyses considered alternative SoC progression, treatment efficacy and treatment-stopping rules. Conclusion: Potential NASH efficacy profiles have differing impacts on predicted long-term outcomes, providing insights for future stakeholders.
DOI: 10.25402/cer.21444834.v1
title: Evaluation of emerging NASH therapies: the impact of treatment efficacy profiles on long-term health outcomes: Supplementary materials

description: Aim: Evaluations of nonalcoholic steatohepatitis (NASH) treatments require predicting lifetime outcomes from short-term clinical trials. Materials & methods: A Markov model with NASH fibrosis stages F0– F3, NASH resolution, compensated cirrhosis (F4/CC), and liver-related complication (LRC) states was developed using literature-based standard of care (SoC) data. Hypothetical efficacy profiles were defined affecting resolution (100%-increase), fibrosis improvement (100% increase), or fibrosis worsening (50% decrease). Results: For the SoC, 10-year LRC rates increased with baseline fibrosis stage (F1: 3.0%; F2: 9.8%; F3: 27.2%; F4/CC: 64.9%). The fibrosis worsening profile reduced predicted 10-year LRC rates (F1: 1.9%; F2: 6.5%; F3: 19.1%; F4/CC: 55.0%) more than the resolution and fibrosis improvement profiles (F1: 2.6%/2.6%; F2: 8.5%/8.3%; F3: 23.3%/23.0%; F4/CC: NA/59.0%). Scenario analyses considered alternative SoC progression, treatment efficacy and treatment-stopping rules. Conclusion: Potential NASH efficacy profiles have differing impacts on predicted long-term outcomes, providing insights for future stakeholders.