cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.9599174
title: Application of Risks Scores in Acute Coronary Syndromes. How Does ProACS Hold Up Against Other Risks Scores?

description: Abstract Background: Multiple risk scores (RS) are approved in the prediction of worse prognosis in acute coronary syndromes (ACS). Recently, the Portuguese Journal of Cardiology has proposed the ProACS RS. Objective: Application of several validated RS, as well as ProACS in patients, admitted for ACS. Evaluation of each RS's performance in predicting in-hospital mortality and the occurrence of all-cause mortality or non-fatal ACS at one-year follow-up and compare them to the ProACS RS. Methods: A retrospective study of ACS was performed. The following RS were applied: GRACE, ACTION Registry-GWTG, PURSUIT, TIMI, EMMACE, SRI, CHA2DS2-VASc-HS, C-ACS and ProACS. ROC Curves were created to determine the predictive power for each RS and then were directly compared to ProACS. Results: The ProACS, ACTION Registry-GWTG and GRACE showed a c-statistics of 0.908, 0.904 and 0.890 for predicting in-hospital mortality, respectively, performing better in ST-segment elevation myocardial infarction patients. The other RS performed satisfactorily, with c-statistics over 0.750, apart from the CHA2DS2-VASc-HS and C-ACS which underperformed. All RS underperformed in predicting worse long-term prognosis revealing c-statistics under 0.700. Conclusion: ProACS is an easily obtained risk score for early stratification of in-hospital mortality. When evaluating all RS, the ProACS, ACTION Registry-GWTG and GRACE RS showed the best performance, demonstrating high capability of predicting a worse prognosis. ProACS was able to demonstrate statistically significant superiority when compared to almost all RS. Thus, the ProACS has showed that it is able to combine simplicity in the calculation of the score with good performance in predicting a worse prognosis.
DOI: 10.6084/m9.figshare.9599174.v1
title: Application of Risks Scores in Acute Coronary Syndromes. How Does ProACS Hold Up Against Other Risks Scores?

description: Abstract Background: Multiple risk scores (RS) are approved in the prediction of worse prognosis in acute coronary syndromes (ACS). Recently, the Portuguese Journal of Cardiology has proposed the ProACS RS. Objective: Application of several validated RS, as well as ProACS in patients, admitted for ACS. Evaluation of each RS's performance in predicting in-hospital mortality and the occurrence of all-cause mortality or non-fatal ACS at one-year follow-up and compare them to the ProACS RS. Methods: A retrospective study of ACS was performed. The following RS were applied: GRACE, ACTION Registry-GWTG, PURSUIT, TIMI, EMMACE, SRI, CHA2DS2-VASc-HS, C-ACS and ProACS. ROC Curves were created to determine the predictive power for each RS and then were directly compared to ProACS. Results: The ProACS, ACTION Registry-GWTG and GRACE showed a c-statistics of 0.908, 0.904 and 0.890 for predicting in-hospital mortality, respectively, performing better in ST-segment elevation myocardial infarction patients. The other RS performed satisfactorily, with c-statistics over 0.750, apart from the CHA2DS2-VASc-HS and C-ACS which underperformed. All RS underperformed in predicting worse long-term prognosis revealing c-statistics under 0.700. Conclusion: ProACS is an easily obtained risk score for early stratification of in-hospital mortality. When evaluating all RS, the ProACS, ACTION Registry-GWTG and GRACE RS showed the best performance, demonstrating high capability of predicting a worse prognosis. ProACS was able to demonstrate statistically significant superiority when compared to almost all RS. Thus, the ProACS has showed that it is able to combine simplicity in the calculation of the score with good performance in predicting a worse prognosis.
DOI: 10.6084/m9.figshare.9599147
title: Incidence of stalk rots in corn hybrids influenced by sowing time and nitrogen rates

description: ABSTRACT Stalk rots compromise the translocation of water and nutrients, affecting grain filling. This study aimed to quantify the incidence of stalk rots in corn hybrids depending on sowing time and nitrogen topdressing rate, and to assess any correlation with grain yield. The experiment was conducted under field conditions in Atalanta, Santa Catarina state, Brazil, using a split-split-plot randomized block design. The hybrids AG 9025 PRO3 (super-early) and 30F53 VYH (early) were sown in the preferential (September 20) and late (December 5) sowing seasons with four nitrogen rates (0, 150, 300, and 450 kg·ha–1). The population density was 75,000 plants·ha–1 andthe nitrogen topdressing was carried out at the V4, V8, and V12 stages. The fungus Colletotrichum graminicola predominated in both hybrids and its presence was negatively correlated with stalk diameter and yield. The hybrid AG9025 PRO3 was more susceptible to stalk rot (35.1%) than the hybrid 30F53 VYH (8.8%). A higher incidence of stalk rot was observed in the late sowing season (31.1%) than in the preferential sowing season (11.2%). A decrease in the incidence of stalk rot was observed in the hybrid AG9025 PRO3 as nitrogen rates increased, but this behavior was not clearly observed in the hybrid 30F53 VYH.
DOI: 10.6084/m9.figshare.9599150
title: Persistence of imazapyr+imazapic in irrigated rice area and effect on soybean due to soil moisture and phytoremediation in the off-season

description: ABSTRACT The residue of imidazolinone herbicides in soil can be detrimental to soybean cultivation in rotation with Clearfield® rice. Thus, this research aimed to evaluate the ryegrass phytoremediation capacity on the imazapyr+imazapic residue in the soil in two soil moisture conditions in the off-season, and the effect on soybean growth in the next growing season. Two experiments were conducted between 2016 and 2017 in Santa Maria, Rio Grande do Sul state, Brazil. It was used the randomized block design in a 3 × 2 factorial. The first factor being the residue in the soil of 0, 210 and 420 g c.p.·ha–1 of the formulated mixture of the herbicides imazapyr+imazapic(525 + 175 g a.i.·kg–1) applied to rice in the 2015/2016 growing season, and the second factor being the presence or absence of ryegrass in the off-season. One experiment was conducted under soil moisture above 70% of field capacity in the off-season, and the other under ambient condition of soil moisture. The soil residue of the application of 420 g c.p.·ha–1 of the imazapyr+imazapic herbicides performed129 days before planting caused phytotoxicity and reduced dry matter of ryegrass under high soil moisture condition in the off-season in irrigated rice areas. Soybean, when planted 359 days after application, has its initial root and shoot growth affected by the residue of 210 and 420 g c.p.·ha–1 rates in high soil moisture condition in the off-season, regardless of ryegrass cultivation during the same period. However, grain yield is not affected.
DOI: 10.6084/m9.figshare.9599150.v1
title: Persistence of imazapyr+imazapic in irrigated rice area and effect on soybean due to soil moisture and phytoremediation in the off-season

description: ABSTRACT The residue of imidazolinone herbicides in soil can be detrimental to soybean cultivation in rotation with Clearfield® rice. Thus, this research aimed to evaluate the ryegrass phytoremediation capacity on the imazapyr+imazapic residue in the soil in two soil moisture conditions in the off-season, and the effect on soybean growth in the next growing season. Two experiments were conducted between 2016 and 2017 in Santa Maria, Rio Grande do Sul state, Brazil. It was used the randomized block design in a 3 × 2 factorial. The first factor being the residue in the soil of 0, 210 and 420 g c.p.·ha–1 of the formulated mixture of the herbicides imazapyr+imazapic(525 + 175 g a.i.·kg–1) applied to rice in the 2015/2016 growing season, and the second factor being the presence or absence of ryegrass in the off-season. One experiment was conducted under soil moisture above 70% of field capacity in the off-season, and the other under ambient condition of soil moisture. The soil residue of the application of 420 g c.p.·ha–1 of the imazapyr+imazapic herbicides performed129 days before planting caused phytotoxicity and reduced dry matter of ryegrass under high soil moisture condition in the off-season in irrigated rice areas. Soybean, when planted 359 days after application, has its initial root and shoot growth affected by the residue of 210 and 420 g c.p.·ha–1 rates in high soil moisture condition in the off-season, regardless of ryegrass cultivation during the same period. However, grain yield is not affected.
DOI: 10.6084/m9.figshare.9599144
title: A SYLLABUS IN THE TEACHING-SERVICE INTEGRATION OF THE MORE DOCTORS PROGRAM AND POSSIBLE CULTURAL EFFECTS

description: Abstract The study had the goal of identifying current changes in the training of medicine professionals that have been brought about by the demands of the More Doctors Program (‘Programa Mais Médicos,’ in Portuguese) in Brazil. The discussions were guided by formulations of the cultural studies in the field of the syllabus. We analyzed articles and research reports on the effects that connect work, learning and changes in the practices of the doctors who integrate the Program. The context of strengthening and development of the Unified Health System (‘Sistema Único de Saúde,’ in Portuguese), certain reforms and political agendas that affect the formal syllabus, and, recently, the implementation of the More Doctors Program itself, are actions that are identified as possibilities created and as spaces where new practices take place within a professional culture that is still biomedical/flexnerian. The results confirmed micro changes in the More Doctors Program that are treated as cultural effects and put into practice in the teaching-service integration, in which the approach of a more humanized work is observed.
DOI: 10.6084/m9.figshare.9599147.v1
title: Incidence of stalk rots in corn hybrids influenced by sowing time and nitrogen rates

description: ABSTRACT Stalk rots compromise the translocation of water and nutrients, affecting grain filling. This study aimed to quantify the incidence of stalk rots in corn hybrids depending on sowing time and nitrogen topdressing rate, and to assess any correlation with grain yield. The experiment was conducted under field conditions in Atalanta, Santa Catarina state, Brazil, using a split-split-plot randomized block design. The hybrids AG 9025 PRO3 (super-early) and 30F53 VYH (early) were sown in the preferential (September 20) and late (December 5) sowing seasons with four nitrogen rates (0, 150, 300, and 450 kg·ha–1). The population density was 75,000 plants·ha–1 andthe nitrogen topdressing was carried out at the V4, V8, and V12 stages. The fungus Colletotrichum graminicola predominated in both hybrids and its presence was negatively correlated with stalk diameter and yield. The hybrid AG9025 PRO3 was more susceptible to stalk rot (35.1%) than the hybrid 30F53 VYH (8.8%). A higher incidence of stalk rot was observed in the late sowing season (31.1%) than in the preferential sowing season (11.2%). A decrease in the incidence of stalk rot was observed in the hybrid AG9025 PRO3 as nitrogen rates increased, but this behavior was not clearly observed in the hybrid 30F53 VYH.
DOI: 10.6084/m9.figshare.9599141
title: Alternative Non-Ionic Pathway for Uncatalyzed Prins Cyclization: DFT Approach

description: Density functional theory calculations (ωB97X-D/6-311++G(d,p)) are employed to investigate an alternative pathway for Prins-like cyclization. Although strong acids usually catalyze this reaction, 4-amino-1,3-dioxanes are rapidly obtained in high yields without catalyst when benzenamines and acetaldehyde react at low temperatures, in aqueous medium. Considering these conditions, we applied a supermolecule model with explicit water molecules to compute the mechanism for 4-amino-1,3-dioxanes formation from the reactants. The structure of the primary solvation shell was determined by Metropolis Monte Carlo method. In the Prins-cyclization step, we found an unpredicted pathway with non-ionic transition structures or intermediates. Explicit water molecules establish a net of hydrogen bonds allowing prototropism, maintaining the electrical neutrality in the system while two protons transfer occurs. To provide data to further experimental confirmation of this hypothesis, we estimated the kinetic isotope effect for the reaction. We also investigated the use of aliphatic amines, which indicates that the reaction may be of a broader application than first observed experimentally.
DOI: 10.6084/m9.figshare.9599144.v1
title: A SYLLABUS IN THE TEACHING-SERVICE INTEGRATION OF THE MORE DOCTORS PROGRAM AND POSSIBLE CULTURAL EFFECTS

description: Abstract The study had the goal of identifying current changes in the training of medicine professionals that have been brought about by the demands of the More Doctors Program (‘Programa Mais Médicos,’ in Portuguese) in Brazil. The discussions were guided by formulations of the cultural studies in the field of the syllabus. We analyzed articles and research reports on the effects that connect work, learning and changes in the practices of the doctors who integrate the Program. The context of strengthening and development of the Unified Health System (‘Sistema Único de Saúde,’ in Portuguese), certain reforms and political agendas that affect the formal syllabus, and, recently, the implementation of the More Doctors Program itself, are actions that are identified as possibilities created and as spaces where new practices take place within a professional culture that is still biomedical/flexnerian. The results confirmed micro changes in the More Doctors Program that are treated as cultural effects and put into practice in the teaching-service integration, in which the approach of a more humanized work is observed.
DOI: 10.6084/m9.figshare.9599132
title: Micro-CT evaluation of apical enlargement of molar root canals using rotary or reciprocating heat-treated NiTi instruments

description: Abstract Objective The aim of this study was to evaluate the root canal preparation and apical enlargement of molar root canals with rotary or reciprocating heat-treated nickel-titanium (NiTi) instruments, by using micro-computed tomography (micro-CT). Methodology Mesial root canals (n=48) of mandibular molars, with a curvature between 20° and 40°, were prepared with ProDesign Logic (PDL) 25.01 and 25.06 in rotary motion, or ProDesign R (PDR) 25.06 in reciprocating motion (PDR). Apical enlargement was performed with PDL35.01 and PDL35.05 or PDR35.05. Scanning with 9 µm resolution was performed before and after preparation, and, after apical enlargement, by using micro-CT. The percentage of volume increase, debris and untouched root canal surface, transportation, centralization and preparation time were analyzed. ANOVA and Tukey or Kruskall-Wallis and Dunn statistical tests were conducted (α=.05). Results PDL promoted a higher apical percentage of volume increase, and lower percentage of debris and untouched root canal surface than PDR 25.06 preparation in entire canal and in all thirds (P.05). Centralization and transportation showed no difference (P&gt;.05). PDR required less time to perform preparation and apical enlargement (P
DOI: 10.6084/m9.figshare.9599135
title: Timing and growing conditions of nitrogen topdressing influence the grain yield and protein content of four wheat cultivars

description: ABSTRACT The application of an adequate rate and splitting of nitrogen is essential for wheat grain yield and protein content. The aim of this work was to adjust nitrogen management approaches regarding agronomic performance and protein content of wheat cultivars in various environments. Field experiments were conducted under no-tillage system on soybean mulch during the 2011 and 2012 growing seasons in Londrina and Pato Branco regions. The experimental design was a randomized block in split plot with four replicates. Four wheat cultivars (IPR Catuara TM, BRS Gaivota, Quartzo, CD 120) were tested with six nitrogen (N) management forms. Were evaluated: number of ears per unit area (NEA); plant height (PH); thousand-kernel weight (TKW); test weight (TW); grain yield (GY); and protein content (PC). The combined ANOVA (p ? 0.01) and Tukey’s test (p ? 0.01) were used. The interaction between cultivars and environments influence all yield components, GY and PC. The interaction management forms of N and environments affected the TKW, NEA, GY and PC. The results showed that in low-rainfall environments, nitrogen topdressing could be suppressed with no negative effects on GY or PC. Under ideal weather conditions, the GY of wheat cultivars was enhanced on application of 60 kg.ha–1 N of urea at the beginning of tillering as well 20 kg.ha–1 of N at booting. Matching the appropriate cultivars to the ideal growth environment is essential for achieving high GY values. The nitrogen forms on the topdressing do not influence the PC of cultivars in Pato Branco.
DOI: 10.6084/m9.figshare.9599141.v1
title: Alternative Non-Ionic Pathway for Uncatalyzed Prins Cyclization: DFT Approach

description: Density functional theory calculations (ωB97X-D/6-311++G(d,p)) are employed to investigate an alternative pathway for Prins-like cyclization. Although strong acids usually catalyze this reaction, 4-amino-1,3-dioxanes are rapidly obtained in high yields without catalyst when benzenamines and acetaldehyde react at low temperatures, in aqueous medium. Considering these conditions, we applied a supermolecule model with explicit water molecules to compute the mechanism for 4-amino-1,3-dioxanes formation from the reactants. The structure of the primary solvation shell was determined by Metropolis Monte Carlo method. In the Prins-cyclization step, we found an unpredicted pathway with non-ionic transition structures or intermediates. Explicit water molecules establish a net of hydrogen bonds allowing prototropism, maintaining the electrical neutrality in the system while two protons transfer occurs. To provide data to further experimental confirmation of this hypothesis, we estimated the kinetic isotope effect for the reaction. We also investigated the use of aliphatic amines, which indicates that the reaction may be of a broader application than first observed experimentally.
DOI: 10.6084/m9.figshare.9599129
title: Assessment of a conservative approach for restoration of extensively destroyed posterior teeth

description: Abstract Extensive restorations in posterior teeth always bring doubts to the clinicians regarding the best protocol, mainly when structures of reinforcement were lost. Objective This study aimed to evaluate the effect of beveling on the fracture resistance and pattern of class II (MOD) restored teeth. Methodology Ninety human premolars were randomly assigned into 9 groups: CTR (control/sound); NC (cavity preparation, non-restored); RU (restored, unbeveled); RTB (restored, entire angle beveling); RPB (restored, partial/occlusal beveling); EC (endodontic access/EA, non-restored); EU (EA, unbeveled); ETB (EA, entire angle beveling); EPB (EA, partial/occlusal beveling). Teeth were restored with Esthet X resin composite and stored in distilled water for 24 h before the inclusion in PVC cylinders. The axial loading tests were performed with 500 kgF at 0.5 mm/min crosshead speed until fracture of the specimens. Fracture resistance and pattern were accessed and data were analyzed using one-way ANOVA and Tukey’s HSD test (α=0.05). Results Mean (±SD) failure loads ranged from 136.56 (11.62) to 174.04 (43.5) kgF in the groups tested without endodontic access. For endodontically accessed teeth, fracture resistance ranged from 95.54 (13.05) to 126.51 (19.88) kgF. Beveling of the cavosurface angle promoted the highest fracture resistance values (p&lt;0.05) and prevented catastrophic fractures. Conclusions Cavosurface angle beveling is capable of improving fracture resistance and pattern for both endodonticaly accessed and non-accessed teeth.
DOI: 10.6084/m9.figshare.9599132.v1
title: Micro-CT evaluation of apical enlargement of molar root canals using rotary or reciprocating heat-treated NiTi instruments

description: Abstract Objective The aim of this study was to evaluate the root canal preparation and apical enlargement of molar root canals with rotary or reciprocating heat-treated nickel-titanium (NiTi) instruments, by using micro-computed tomography (micro-CT). Methodology Mesial root canals (n=48) of mandibular molars, with a curvature between 20° and 40°, were prepared with ProDesign Logic (PDL) 25.01 and 25.06 in rotary motion, or ProDesign R (PDR) 25.06 in reciprocating motion (PDR). Apical enlargement was performed with PDL35.01 and PDL35.05 or PDR35.05. Scanning with 9 µm resolution was performed before and after preparation, and, after apical enlargement, by using micro-CT. The percentage of volume increase, debris and untouched root canal surface, transportation, centralization and preparation time were analyzed. ANOVA and Tukey or Kruskall-Wallis and Dunn statistical tests were conducted (α=.05). Results PDL promoted a higher apical percentage of volume increase, and lower percentage of debris and untouched root canal surface than PDR 25.06 preparation in entire canal and in all thirds (P.05). Centralization and transportation showed no difference (P&gt;.05). PDR required less time to perform preparation and apical enlargement (P
DOI: 10.6084/m9.figshare.9599135.v1
title: Timing and growing conditions of nitrogen topdressing influence the grain yield and protein content of four wheat cultivars

description: ABSTRACT The application of an adequate rate and splitting of nitrogen is essential for wheat grain yield and protein content. The aim of this work was to adjust nitrogen management approaches regarding agronomic performance and protein content of wheat cultivars in various environments. Field experiments were conducted under no-tillage system on soybean mulch during the 2011 and 2012 growing seasons in Londrina and Pato Branco regions. The experimental design was a randomized block in split plot with four replicates. Four wheat cultivars (IPR Catuara TM, BRS Gaivota, Quartzo, CD 120) were tested with six nitrogen (N) management forms. Were evaluated: number of ears per unit area (NEA); plant height (PH); thousand-kernel weight (TKW); test weight (TW); grain yield (GY); and protein content (PC). The combined ANOVA (p ? 0.01) and Tukey’s test (p ? 0.01) were used. The interaction between cultivars and environments influence all yield components, GY and PC. The interaction management forms of N and environments affected the TKW, NEA, GY and PC. The results showed that in low-rainfall environments, nitrogen topdressing could be suppressed with no negative effects on GY or PC. Under ideal weather conditions, the GY of wheat cultivars was enhanced on application of 60 kg.ha–1 N of urea at the beginning of tillering as well 20 kg.ha–1 of N at booting. Matching the appropriate cultivars to the ideal growth environment is essential for achieving high GY values. The nitrogen forms on the topdressing do not influence the PC of cultivars in Pato Branco.