cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.5281/zenodo.14172161
title: Safety and Efficacy of Mesenchymal Stromal Cells Mitochondria Transplantation as a Cell-Free Therapy for Osteoarthritis

description: Abstract

Objective

The inflammatory responses from synovial fibroblasts and macrophages and the mitochondrial dysfunction in chondrocytes leading to oxidative stress, disrupt extracellular matrix (ECM) homeostasis and accelerate the deterioration process of articular cartilage in osteoarthritis (OA).  In the last years, it has been proposed that mesenchymal stromal cells (MSC) transfer their functional mitochondria to damaged cells in response to cellular stress, becoming one of the mechanisms underpinning their therapeutic effects. Therefore, we hypothesize that a novel cell-free treatment for OA could involve direct mitochondria transplantation, leading to the restoration of both cellular and mitochondrial homeostasis.

Methods

Mitochondria were isolated from Umbilical Cord (UC)-MSC (Mito-MSC) and characterized based on their morphology, phenotype, functions, and their ability to be internalized by different articular cells. Furthermore, the transcriptional changes following mitochondrial uptake by chondrocytes were evaluated using an Affymetrix analysis, Lastly, the dose dependance therapeutic efficacy, biodistribution and immunogenicity of Mito-MSC were assessed in vivo, through an intra-articular injection in male C57BL6 mice in a collagenase-induced OA (CIOA) model.

Results

Our findings demonstrate the functional integrity of Mito-MSC and their ability to be efficiently transferred into chondrocytes, synovial macrophages, and synovial fibroblasts. Moreover, the transcriptomic analysis showed the upregulation of genes involved in stress such as DNA reparative machinery and inflammatory antiviral responses.  Finally, Mito-MSC transplantation yielded significant reductions in joint mineralization, a hallmark of OA progression, as well as improvements in OA-related histological signs, with the lower dose exhibiting better therapeutic efficacy.  Furthermore, Mito-MSC were detected within the knee joint for up to 24 hours post-injection without eliciting an inflammatory response in CIOA mice. 

Conclusion

 Collectively, our results reveal that mitochondria derived from MSC are transferred to key articular cells and are retained in the joint without generating an inflammatory immune response mitigating articular cartilage degradation in OA, probably through a restorative effect trigger by the stress antiviral response within OA chondrocytes.
DOI: 10.15468/dl.ygcukq
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Matsucoccus matsumurae (Kuwana, 1905)",
 "Country is China",
 "Year is greater than or equal to 1500"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0017195-241107131044228/datasets/export for details.
DOI: 10.15468/dl.m6mc9b
title: Occurrence Download

description: A dataset containing 76391 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Microtus pennsylvanicus (Ord, 1815)"
 ]
}

 The dataset includes 76391 records from 160 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0017196-241107131044228/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.4un25v
title: Occurrence Download

description: A dataset containing 34693 species occurrences available in GBIF matching the query:
{
 "and" : [
 "GadmGid is MEX.25.7_2",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 "TaxonKey is Aves"
 ]
}

 The dataset includes 34693 records from 30 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0017199-241107131044228/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.bpr8fz
title: Occurrence Download

description: A dataset containing 2156147 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Meleagris gallopavo Linnaeus, 1758",
 "Country is United States of America",
 "Year is greater than or equal to 1500"
 ]
}

 The dataset includes 2156147 records from 121 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0017198-241107131044228/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.jrx8zu
title: Occurrence Download

description: A dataset containing 4698 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Ambystoma rosaceum Taylor, 1941"
 ]
}

 The dataset includes 4698 records from 38 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0017200-241107131044228/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.k22thj
title: Occurrence Download

description: A dataset containing 2052 species occurrences available in GBIF matching the query:
{
 "DatasetKey" : [
 "is Invasive species - Invasive plants near waterways in West and East Flanders, Belgium"
 ]
}

 The dataset includes 2052 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0017201-241107131044228/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.qxbpex
title: Occurrence Download

description: A dataset containing 595 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Agkistrodon bilineatus Günther, 1863"
 ]
}

 The dataset includes 595 records from 67 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0017202-241107131044228/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.5281/zenodo.14172191
title: Cytvol
DOI: 10.5281/zenodo.14172192
title: Cytvol
DOI: 10.15468/dl.t5b3e7
title: Occurrence Download

description: A dataset containing 8796938 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is Chile",
 "Geometry POLYGON((-72.91856 -54.45363,-64.20563 -54.45363,-72.18106 -52.21376,-73.11411 -49.58883,-72.04339 -48.1808,-72.04339 -45.24527,-71.34351 -39.51878,-71.10112 -36.73415,-69.44307 -29.68931,-67.60755 -18.97983,-72.91856 -18.94367,-72.50227 -30.08716,-78.35155 -48.68822,-72.91856 -54.45363))",
 "HasGeospatialIssue is false"
 ]
}

 The dataset includes 8796938 records from 1149 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0017194-241107131044228/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.5281/zenodo.17227611
title: supplemental files for Transcriptomics uncovers a core set of genes in kochia revealing the molecular physiology behind crop-weed interaction
DOI: 10.5281/zenodo.17227612
title: supplemental files for Transcriptomics uncovers a core set of genes in kochia revealing the molecular physiology behind crop-weed interaction
DOI: 10.15468/dl.dxgg33
title: Occurrence Download

description: A dataset containing 79 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Tenarea tortuosa)",
 "BasisOfRecord is one of (Specimen, Literature Occurrence, Human Observation, Observation)",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "Year is greater than or equal to 1991",
 "Year is less than or equal to 2025"
 ]
}

 The dataset includes 79 records from 10 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0030358-250920141307145/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.26uf2m
title: Occurrence Download

description: A dataset containing 19 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Solanum sisymbriifolium",
 "Country is Japan",
 "HasCoordinate is true"
 ]
}

 The dataset includes 19 records from 8 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0030357-250920141307145/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.334fuc
title: Occurrence Download

description: A dataset containing 79 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Tenarea tortuosa)",
 "BasisOfRecord is one of (Specimen, Literature Occurrence, Human Observation, Observation)",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "Year is greater than or equal to 1991",
 "Year is less than or equal to 2025"
 ]
}

 The dataset includes 79 records from 10 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0030359-250920141307145/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.r84nvy
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Pomatorhinus musicus",
 "Country is one of (Brunei Darussalam, Indonesia, Philippines, Timor-Leste, Singapore)",
 "HasCoordinate is true"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0030360-250920141307145/datasets/export for details.
DOI: 10.15468/dl.x68kb4
title: Occurrence Download

description: A dataset containing 2 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Pediastrum integrum",
 "Geometry POLYGON((119.300000 20.500000, 122.100000 20.500000, 122.100000 25.400000, 119.300000 25.400000, 119.300000 20.500000))",
 "HasCoordinate is true",
 "HasGeospatialIssue is false"
 ]
}

 The dataset includes 2 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0030361-250920141307145/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.7dxg8z
title: Occurrence Download

description: A dataset containing 281410 species occurrences available in GBIF matching the query:
{
 "and" : [
 "BasisOfRecord is one of (Machine Observation, Human Observation, Material sample, Material citation, Specimen, Living Specimen, Occurrence evidence)",
 "Issue is one of (Coordinate rounded, Geodetic datum assumed WGS84, Collection match none, Institution match none, Institution collection mismatch)",
 "OccurrenceStatus is Present",
 "TaxonKey is Mytilidae"
 ]
}

 The dataset includes 281410 records from 832 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0030286-250920141307145/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.f5u9p3
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Solanum sisymbriifolium",
 "Country is Latvia",
 "HasCoordinate is true"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0030362-250920141307145/datasets/export for details.
DOI: 10.15468/dl.qpj7z6
title: Occurrence Download

description: A dataset containing 2 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Solanum sisymbriifolium",
 "Country is Nepal",
 "HasCoordinate is true"
 ]
}

 The dataset includes 2 records from 2 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0030365-250920141307145/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.hpjern
title: Occurrence Download

description: A dataset containing 5080 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Rousettus aegyptiacus)",
 "BasisOfRecord is one of (Specimen, Literature Occurrence, Human Observation, Observation)",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "Year is greater than or equal to 1991",
 "Year is less than or equal to 2025"
 ]
}

 The dataset includes 5080 records from 36 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0030363-250920141307145/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.2vtmhk
title: Occurrence Download

description: A dataset containing 2734 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Talpa occidentalis)",
 "BasisOfRecord is one of (Specimen, Literature Occurrence, Human Observation, Observation)",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "Year is greater than or equal to 1991",
 "Year is less than or equal to 2025"
 ]
}

 The dataset includes 2734 records from 13 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0030364-250920141307145/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.wqrq5c
title: Occurrence Download

description: A dataset containing 73 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Solanum sisymbriifolium",
 "Country is Netherlands",
 "HasCoordinate is true"
 ]
}

 The dataset includes 73 records from 8 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0030366-250920141307145/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.wj4tfx
title: Occurrence Download

description: A dataset containing 1 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Titanoderma ramosissimum)",
 "BasisOfRecord is one of (Specimen, Literature Occurrence, Human Observation, Observation)",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "Year is greater than or equal to 1991",
 "Year is less than or equal to 2025"
 ]
}

 The dataset includes 1 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0030367-250920141307145/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.cgb9s2
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Pomatorhinus schisticeps",
 "Country is one of (Brunei Darussalam, Indonesia, Philippines, Timor-Leste, Singapore)",
 "HasCoordinate is true"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0030368-250920141307145/datasets/export for details.
DOI: 10.15468/dl.36urx9
title: Occurrence Download

description: A dataset containing 1 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Pediastrum ovatum",
 "Geometry POLYGON((119.300000 20.500000, 122.100000 20.500000, 122.100000 25.400000, 119.300000 25.400000, 119.300000 20.500000))",
 "HasCoordinate is true",
 "HasGeospatialIssue is false"
 ]
}

 The dataset includes 1 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0030369-250920141307145/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.zbtmgp
title: Occurrence Download

description: A dataset containing 1290 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Rugulopteryx okamurae)",
 "BasisOfRecord is one of (Specimen, Literature Occurrence, Human Observation, Observation)",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "Year is greater than or equal to 1991",
 "Year is less than or equal to 2025"
 ]
}

 The dataset includes 1290 records from 21 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0030370-250920141307145/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.bf36mb
title: Occurrence Download

description: A dataset containing 18342 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Tamias sibiricus)",
 "BasisOfRecord is one of (Specimen, Literature Occurrence, Human Observation, Observation)",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "Year is greater than or equal to 1991",
 "Year is less than or equal to 2025"
 ]
}

 The dataset includes 18342 records from 139 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0030371-250920141307145/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.29t2kv
title: Occurrence Download

description: A dataset containing 9 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Solanum sisymbriifolium",
 "Country is Poland",
 "HasCoordinate is true"
 ]
}

 The dataset includes 9 records from 2 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0030372-250920141307145/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.b64t6d
title: Occurrence Download

description: A dataset containing 45 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Solanum sisymbriifolium",
 "Country is Sweden",
 "HasCoordinate is true"
 ]
}

 The dataset includes 45 records from 4 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0030373-250920141307145/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.3886/e199145
title: Data and Code for: Real Exchange Rates and Endogenous Productivity

description: Two-thirds of the real exchange rate's (RER) volatility occurs at low frequencies. We provide empirical evidence that links movements in the RER to changes in research and development spending and patents. A two-country real business cycle model with endogenous productivity and a gradual dissemination of ideas can rationalize these facts. Endogenous productivity alters RER dynamics by inducing (1) a persistent gap in productivity between countries and (2) a reallocation of resources towards research and development spending. The estimated full model effortlessly replicates the dynamic properties of the RER at all horizons without sacrificing the model's fit along other dimensions.
DOI: 10.15468/dl.skj9ej
title: Occurrence Download

description: A dataset containing 25673 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is Mexico",
 "TaxonKey is Ageratina"
 ]
}

 The dataset includes 25673 records from 217 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0030374-250920141307145/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.3886/e199145v1
title: Data and Code for: Real Exchange Rates and Endogenous Productivity

description: Two-thirds of the real exchange rate's (RER) volatility occurs at low frequencies. We provide empirical evidence that links movements in the RER to changes in research and development spending and patents. A two-country real business cycle model with endogenous productivity and a gradual dissemination of ideas can rationalize these facts. Endogenous productivity alters RER dynamics by inducing (1) a persistent gap in productivity between countries and (2) a reallocation of resources towards research and development spending. The estimated full model effortlessly replicates the dynamic properties of the RER at all horizons without sacrificing the model's fit along other dimensions.
DOI: 10.15468/dl.ggw73k
title: Occurrence Download

description: A dataset containing 472 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Tonna galea)",
 "BasisOfRecord is one of (Specimen, Literature Occurrence, Human Observation, Observation)",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "Year is greater than or equal to 1991",
 "Year is less than or equal to 2025"
 ]
}

 The dataset includes 472 records from 37 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0030376-250920141307145/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.apd94u
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Solanum sisymbriifolium",
 "Country is Uzbekistan",
 "HasCoordinate is true"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0030375-250920141307145/datasets/export for details.
DOI: 10.15468/dl.vdhzw5
title: Occurrence Download

description: A dataset containing 265 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is one of (Brazil, Argentina, Uruguay)",
 "TaxonKey is Adurgoa"
 ]
}

 The dataset includes 265 records from 2 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0030378-250920141307145/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.rsctd6
title: Occurrence Download

description: A dataset containing 472 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Tonna galea)",
 "BasisOfRecord is one of (Specimen, Literature Occurrence, Human Observation, Observation)",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "Year is greater than or equal to 1991",
 "Year is less than or equal to 2025"
 ]
}

 The dataset includes 472 records from 37 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0030377-250920141307145/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.6zzftx
title: Occurrence Download

description: A dataset containing 28618 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Rupicapra pyrenaica)",
 "BasisOfRecord is one of (Specimen, Literature Occurrence, Human Observation, Observation)",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "Year is greater than or equal to 1991",
 "Year is less than or equal to 2025"
 ]
}

 The dataset includes 28618 records from 140 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0030380-250920141307145/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.h9922d
title: Occurrence Download

description: A dataset containing 36 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Pediastrum simplex",
 "Geometry POLYGON((119.300000 20.500000, 122.100000 20.500000, 122.100000 25.400000, 119.300000 25.400000, 119.300000 20.500000))",
 "HasCoordinate is true",
 "HasGeospatialIssue is false"
 ]
}

 The dataset includes 36 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0030381-250920141307145/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.