cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.4898162
title: PowerPoint Slides for: Thiazide-Associated Hyponatremia, Report of the Hyponatremia Registry: An Observational Multicenter International Study

description: <b><i>Background:</i></b> Hyponatremia is a frequent and potentially life-threatening adverse side effect of thiazide diuretics. This sub-analysis of the Hyponatremia Registry database focuses on current management practices of thiazide-associated hyponatremia (TAH) and compares differences between TAH and syndrome of inappropriate antidiuretic hormone secretion (SIADH). <b><i>Methods:</i></b> We analyzed 477 patients from 225 US and EU sites with euvolemic hyponatremia ([Na<sup>+</sup>] ≤130 mEq/L) who were receiving a thiazide diuretic. Of these, 118 met criteria for true thiazide-induced hyponatremia (TIH). <b><i>Results:</i></b> Thiazide was withdrawn immediately after hyponatremia was diagnosed only in 57% of TAH; in these patients, the median rate of [Na<sup>+</sup>] change (Δ<sub>daily</sub>[Na<sup>+</sup>]) was significantly higher than those with continued thiazide treatment (3.8 [interquartile range: 4.0] vs. 1.7 [3.8] mEq/L/day). The most frequently employed therapies were isotonic saline (29.6%), fluid restriction (19.9%), the combination of these two (8.2%), and hypertonic saline (5.2%). Hypertonic saline produced the greatest Δ<sub>daily</sub>[Na<sup>+</sup>] (8.0[6.4] mEq/L/day) followed by a combination of fluid restriction and normal saline (4.5 [3.8] mEq/L/day) and normal saline alone (3.6 [3.5] mEq/L/day). Fluid restriction was markedly less effective (2.7 [2.7] mEq/L/day). Overly rapid correction of hyponatremia occurred in 3.1% overall, but in up to 21.4% given hypertonic saline. Although there are highly significant differences in the biochemical profiles between TIH and SIADH, no predictive diagnostic test could be derived. <b><i>Conclusions:</i></b> Despite its high incidence and potential risks, the management of TAH is often poor. Immediate withdrawal of the thiazide is crucial for treatment success. Hypertonic saline is most effective in correcting hyponatremia but associated with a high rate of overly rapid correction. We could not establish a diagnostic laboratory-based test to differentiate TIH from SIADH.
DOI: 10.6084/m9.figshare.4898171.v1
title: PowerPoint Slides for: Psychosocial Factors and 30-Day Hospital Readmission among Individuals Receiving Maintenance Dialysis: A Prospective Study

description: <b><i>Background:</i></b> Thirty-day hospital readmissions are common among maintenance dialysis patients. Prior studies have evaluated easily measurable readmission risk factors such as comorbid conditions, laboratory results, and hospital discharge day. We undertook this prospective study to investigate the associations between hospital-assessed depression, health literacy, social support, and self-rated health (separately) and 30-day hospital readmission among dialysis patients. <b><i>Methods:</i></b> Participants were recruited from the University of North Carolina Hospitals, 2014-2016. Validated depression, health literacy, social support, and self-rated health screening instruments were administered during index hospitalizations. Multivariable logistic regression models with 30-day readmission as the dependent outcome were used to examine readmission risk factors. <b><i>Results:</i></b> Of the 154 participants, 58 (37.7%) had a 30-day hospital readmission. In unadjusted analyses, individuals with positive screening for depression, lower health literacy, and poorer social support were more likely to have a 30-day readmission (vs. negative screening). Positive depression screening and poorer social support remained significantly associated with 30-day readmission in models adjusted for race, heart failure, admitting service, weekend discharge day, and serum albumin: adjusted OR (95% CI) 2.33 (1.02-5.15) for positive depressive symptoms and 2.57 (1.10-5.91) for poorer social support. The area under the receiver operating characteristic curve (AUC) of the multivariable model adjusted for social support status was significantly greater than the AUC of the multivariable model without social support status (test for equality; <i>p</i> value = 0.04). <b><i>Conclusion:</i></b> Poor social support and depressive symptoms identified during hospitalizations may represent targetable readmission risk factors among dialysis patients. Our findings suggest that hospital-based assessments of select psychosocial factors may improve readmission risk prediction.
DOI: 10.6084/m9.figshare.4898159
title: PowerPoint Slides for: Pneumatic Compression, But Not Exercise, Can Avoid Intradialytic Hypotension: A Randomized Trial

description: <b><i>Background:</i></b> Conventional hemodialysis (HD) is associated with dialysis-induced hypotension (DIH) and ineffective phosphate removal. As the main source of extracellular fluid removed during HD are the legs, we sought to reduce DIH and increase phosphate removal by using cycling and pneumatic compression, which would potentially provide higher venous return, preserving central blood flow and also offering more phosphate to the dialyzer. <b><i>Methods:</i></b> We evaluated 21 patients in a randomized crossover fashion in which each patient underwent 3 different HD: control; cycling exercise during the first 60 min; and pneumatic compression during the first 60 min. Data obtained included bioelectrical impedance, hourly blood pressure measurement, biochemical parameters, and direct quantification of phosphate through the dialysate. DIH was defined as a drop in mean arterial pressure (MAP) ≥20 mm Hg. <b><i>Results:</i></b> There was no difference in the ultrafiltration rate (<i>p</i> = 0.628), delta weight (<i>p</i> = 0.415), delta of total, intra and extracellular body water among the control, cycling, and pneumatic compression (<i>p</i> = 0.209, <i>p</i> = 0.348, and <i>p</i> = 0.467 respectively). Delta MAP was less changed by pneumatic compression when compared to control, cycling, and pneumatic compression respectively (-4.7 [-17.2, 8.2], -4.7 [-20.5, -0.2], and -2.3 [-8.1, 9.0] mm Hg; <i>p</i> = 0.021). DIH occurred in 43, 38, and 24% of patients in control, cycling, and pneumatic compression respectively (<i>p</i> = 0.014). Phosphate removal did not increase in any intervention (<i>p</i> = 0.486). Higher phosphate removal was dependent on ultrafiltration, pre dialysis serum phosphate, and higher parathyroid hormone. <b><i>Conclusion:</i></b> Pneumatic compression during the first hour of dialysis was associated with less DIH, albeit there was no effect on fluid parameters. Neither exercise nor pneumatic compression increased phosphate removal.
DOI: 10.6084/m9.figshare.4898147
title: Dataset.sav

description: Dataset on the impact of educative suicide prevention websites on audiences(Papageno vs. Werther effect online: Randomized controlled trial of beneficial and harmful impacts of educative suicide prevention websites)
DOI: 10.6084/m9.figshare.4898138
title: Molecular dynamics, thermodynamic, and mutational binding studies for tumor-specific LyP-1 in complex with p32

description: Recent studies in tumor homing peptides have shown the specificity of LyP-1 (CGNKRTRGC) to tumor lymphatics. In this present work, we evaluated the possible interactions between cyclic LyP-1 and its receptor, p32, with molecular dynamics and docking studies in order to lead the design of novel LyP-1 derivatives, which could bind to p32 more effectively and perform enhanced antitumor effect. The total binding enthalpy energies have been obtained by MM-PBSA thermodynamic computations and the favorability of p32.LyP-1 complex in water has been shown by explicit water MD computations. The last 30 ns of molecular dynamics trajectory have shown the strong interaction of LyP-1 with the inner surface chains of p32, especially with chains B and C. ALA-SCAN mutagenesis studies have indicated the considerable influence of Asn3, Lys4, Arg5, and Arg7 amino acid residues on the specific binding of LyP-1. Within the knowledge of the critical role of p32 receptor in cancer cell metabolism, this study can lead to further developments in anticancer therapy by targeting p32 with LyP-1 derivatives as active targeting moiety. This data can also be applied for the development of new drug delivery systems in which LyP-1 can be used for its targeting and anticancer properties.
DOI: 10.6084/m9.figshare.4898141
title: Standing Iguanodon in Crystal Palace Park: condition survey documents

description: Survey to assess structural deterioration in the Standing Iguanodon in Crystal Palace Park (https://en.wikipedia.org/wiki/Crystal_Palace_Dinosaurs). Complete dataset consists largely of photogrammetry data from a single statue with 2x crack reports taken at an interval of 3 months. Metadata is in Archaeology Data Service recommended formats. For related 3D data see https://doi.org/10.6084/m9.figshare.4898921
DOI: 10.6084/m9.figshare.4898141.v1
title: Standing Iguanodon in Crystal Palace Park: condition survey documents

description: Survey to assess structural deterioration in the Standing Iguanodon in Crystal Palace Park (https://en.wikipedia.org/wiki/Crystal_Palace_Dinosaurs). Complete dataset consists largely of photogrammetry data from a single statue with 2x crack reports taken at an interval of 3 months. Metadata is in Archaeology Data Service recommended formats.
DOI: 10.6084/m9.figshare.4898138.v1
title: Molecular dynamics, thermodynamic, and mutational binding studies for tumor-specific LyP-1 in complex with p32

description: Recent studies in tumor homing peptides have shown the specificity of LyP-1 (CGNKRTRGC) to tumor lymphatics. In this present work, we evaluated the possible interactions between cyclic LyP-1 and its receptor, p32, with molecular dynamics and docking studies in order to lead the design of novel LyP-1 derivatives, which could bind to p32 more effectively and perform enhanced antitumor effect. The total binding enthalpy energies have been obtained by MM-PBSA thermodynamic computations and the favorability of p32.LyP-1 complex in water has been shown by explicit water MD computations. The last 30 ns of molecular dynamics trajectory have shown the strong interaction of LyP-1 with the inner surface chains of p32, especially with chains B and C. ALA-SCAN mutagenesis studies have indicated the considerable influence of Asn3, Lys4, Arg5, and Arg7 amino acid residues on the specific binding of LyP-1. Within the knowledge of the critical role of p32 receptor in cancer cell metabolism, this study can lead to further developments in anticancer therapy by targeting p32 with LyP-1 derivatives as active targeting moiety. This data can also be applied for the development of new drug delivery systems in which LyP-1 can be used for its targeting and anticancer properties.
DOI: 10.6084/m9.figshare.4898114
title: Home range and habitat use of Trumpeter Hornbills <i>Bycanistes bucinator</i> in an urban–forest mosaic, Eshowe, South Africa<sup>§</sup>

description: Despite the negative impacts of urbanisation, some species adapt to pressures of habitat loss and fragmentation. Trumpeter Hornbills <i>Bycanistes bucinator</i> are a large avian forest frugivore that uses urban environments in South Africa. Consequently, we used GPS/UHF transmitters to study their home range size, movement and habitat use in an urban–forest mosaic in Eshowe, South Africa from March to October 2014. We estimated the home range size using three methods: minimum convex polygon (MCP), kernel density estimation (KDE) and local convex hull (LoCoH). Our results showed that overall monthly home range size was 5.1 ± 1.28 km<sup>2</sup> (mean ± SE; 95% MCP), 4.6 ± 1.14 km<sup>2</sup> (95% KDE) and 1.9 ± 0. 46 km<sup>2</sup> (95% LoCoH). However, individual home range sizes varied monthly and seasonally. We found that all individuals tagged used mostly the indigenous forest and frequently utilised urban residential areas (gardens) with little or no use of cultivated land. Observed individual variations in monthly and seasonal home ranges could be a response to variations in availability of key fruit resources in the urban residential and indigenous forest mosaic. This study supports the use of more than one method of home range estimation for insight regarding home range and habitat use in urban–forest mosaics for this large forest frugivore.
DOI: 10.6084/m9.figshare.4898108
title: Supplementary Material for: The Aachen Minipig: Phenotype, Genotype, Hematological and Biochemical Characterization, and Comparison to the Göttingen Minipig

description: <b><i>Background:</i></b> The pig is one of the most frequently used large animal models for biomedical research, especially in the field of translational research and surgical models. While standard livestock breeds are used in short-term and acute studies, minipig breeds are the preferred breeds in long-term and chronic studies due to their limited growth and body weight. <b><i>Objective:</i></b> In consideration of the 3R principle (refinement, reduction, replacement) and the increasing demand, the aim of this study was to generate a new, robust, non-specific-pathogen-free minipig breed, the Aachen minipig. <b><i>Methods:</i></b> Phenotype, genotype, and hematological as well as clinical chemistry parameters were characterized, and reference values of the Aachen minipig were generated and compared to the values in the commonly used Göttingen minipig. Organ weights of the heart, kidney, liver, lung, spleen, and brain were determined using a laboratory balance. Blood samples were collected for hematology and clinical chemistry. Assessment of genetic diversity was performed by microsatellite markers. Nasal swabs were collected from 11 individual minipigs representing 6 races for DNA extraction. DNA was quantified and the identity and origin of the Aachen minipigs at the genomic level was determined by microsatellites. <b><i>Results:</i></b> The Aachen minipig established here is based on the Mini-LEWE breed and consists of the Vietnamese potbelly pig, the Schwäbisch Hällisch Landpig, the German Landrace, and the Minnesota minipig. Relative organ weights (lung, heart, kidneys, brain), hematology (hemoglobin, hematocrit, platelet count, mean corpuscular hemoglobin concentration, segmented neutrophils, lymphocytes, eosinophils, basophils), and clinical chemistry parameters (sodium, calcium, chloride, alkaline phosphatase, aspartate aminotransferase, alanine aminotransferase, gamma-glutamyl transferase, lactate dehydrogenase, triglycerides, blood urea nitrogen, creatinine, total bilirubin, total protein, creatine kinase) of the Aachen minipigs and the Göttingen minipigs were not significantly different. Significant differences where only seen in relative organ weights (liver, spleen), hematology (red blood cell count, mean corpuscular volume, mean corpuscular hemoglobin, white blood cell count, banded neutrophils, monocytes), and clinical chemistry parameters (inorganic phosphorus, potassium, glucose, cholesterol, albumin, amylase). <b><i>Conclusion:</i></b> The Aachen minipig is a suitable model for research due to its similarity to other minipig breeds, especially the Göttingen minipig. The reference values established in this study may be used for the comparison of scientific data and encourage the use of the Aachen minipig as an animal model for biomedical research.
DOI: 10.6084/m9.figshare.4898111
title: Supplementary Material for: The cHS4 Chromatin Insulator Reduces the Rate of Retroviral Vector-Mediated Gene Dysregulation Associated with Aberrant Vector Transcription

description: Integrating gammaretroviral vectors can dysregulate the expression of cellular genes through a variety of mechanisms, leading to genotoxicity and malignant transformation. Although most attention has focused on the activation of cellular genes by vector enhancers, aberrant fusion transcripts involving cellular gene sequences and vector promoters, vector splice elements, and vector transcription termination sequences have also been mechanistically associated with dysregulated expression of cellular genes. Chromatin insulators have emerged as an effective tool for reducing the frequency of vector-mediated genotoxicity and malignant transformation and have been shown to block the activation of cellular genes by vector enhancers. We report here evidence that flanking a gammaretroviral reporter vector with the cHS4 chromatin insulator also reduces the frequency of vector-mediated cellular gene dysregulation associated with aberrant vector transcripts, including vector transcription run-through and aberrant splicing. We demonstrate that the cHS4 element does not function to terminate transcription directly, implicating other mechanisms for this activity.
DOI: 10.6084/m9.figshare.4898144.v1
title: Multilanguage Written Picture Naming Database

description: Timed naming data in 14 European languages for pictures in the Rossion and Pourtois (2004) colourised version of the Snodgrass and Vanderwart (1980) set of pictures of 260 everyday objects. For each language we provide by-picture "norms", including name and spelling diversity, response time and mean interkey-interval. We also provide the by-trial data from which these were derived. Please see the Readme file for more details and <br>Torrance, M., Nottbusch, G., Alves, R. A., Arfé, B., Chanquoy, L., Chukharev-Hudilainen, E., … Wengelin, Å. (in press). Timed Written Picture Naming in 14 European Languages. <i>Behavior Research Methods</i>.for a full explanation.<br>
DOI: 10.6084/m9.figshare.4898099
title: Multiscale modeling of in-room temperature distribution with human occupancy data: a practical case study

description: This paper develops a method for modelling of in-room temperature distribution incorporated with data collected by human sensors. This modelling is based on a standard two-dimensional heat diffusion equation with an effective diffusion coefficient. The effective diffusion coefficient is nominally identified from characteristics of air flow inside a room and its architectural design. For modelling multiple time-scale influence of human occupancy on the in-room temperature distribution, two independent parameters—the effective diffusion coefficient and human heat input—of the equation are modulated with the human sensor data that capture spatio-temporal dynamics of the occupancy in high resolution. The developed method is applied to a practical office space in commercial building in Japan so that its effectiveness is demonstrated by comparing numerical simulations of the equation with measured data on temperature.
DOI: 10.6084/m9.figshare.4898111.v1
title: Supplementary Material for: The cHS4 Chromatin Insulator Reduces the Rate of Retroviral Vector-Mediated Gene Dysregulation Associated with Aberrant Vector Transcription

description: Integrating gammaretroviral vectors can dysregulate the expression of cellular genes through a variety of mechanisms, leading to genotoxicity and malignant transformation. Although most attention has focused on the activation of cellular genes by vector enhancers, aberrant fusion transcripts involving cellular gene sequences and vector promoters, vector splice elements, and vector transcription termination sequences have also been mechanistically associated with dysregulated expression of cellular genes. Chromatin insulators have emerged as an effective tool for reducing the frequency of vector-mediated genotoxicity and malignant transformation and have been shown to block the activation of cellular genes by vector enhancers. We report here evidence that flanking a gammaretroviral reporter vector with the cHS4 chromatin insulator also reduces the frequency of vector-mediated cellular gene dysregulation associated with aberrant vector transcripts, including vector transcription run-through and aberrant splicing. We demonstrate that the cHS4 element does not function to terminate transcription directly, implicating other mechanisms for this activity.
DOI: 10.6084/m9.figshare.4898144.v2
title: Multilanguage Written Picture Naming Database

description: Timed naming data in 14 European languages for pictures in the Rossion and Pourtois (2004) colourised version of the Snodgrass and Vanderwart (1980) set of pictures of 260 everyday objects. For each language we provide by-picture "norms", including name and spelling diversity, response time and mean interkey-interval. We also provide the by-trial data from which these were derived. Please see the Readme file for more details and <br>Torrance, M., Nottbusch, G., Alves, R. A., Arfé, B., Chanquoy, L., Chukharev-Hudilainen, E., … Wengelin, Å. (in press). Timed Written Picture Naming in 14 European Languages. <i>Behavior Research Methods</i>.for a full explanation.<br>
DOI: 10.6084/m9.figshare.4898099.v1
title: Multiscale modeling of in-room temperature distribution with human occupancy data: a practical case study

description: This paper develops a method for modelling of in-room temperature distribution incorporated with data collected by human sensors. This modelling is based on a standard two-dimensional heat diffusion equation with an effective diffusion coefficient. The effective diffusion coefficient is nominally identified from characteristics of air flow inside a room and its architectural design. For modelling multiple time-scale influence of human occupancy on the in-room temperature distribution, two independent parameters—the effective diffusion coefficient and human heat input—of the equation are modulated with the human sensor data that capture spatio-temporal dynamics of the occupancy in high resolution. The developed method is applied to a practical office space in commercial building in Japan so that its effectiveness is demonstrated by comparing numerical simulations of the equation with measured data on temperature.
DOI: 10.6084/m9.figshare.4898114.v2
title: Home range and habitat use of Trumpeter Hornbills <i>Bycanistes bucinator</i> in an urban–forest mosaic, Eshowe, South Africa<sup>§</sup>

description: Despite the negative impacts of urbanisation, some species adapt to pressures of habitat loss and fragmentation. Trumpeter Hornbills <i>Bycanistes bucinator</i> are a large avian forest frugivore that uses urban environments in South Africa. Consequently, we used GPS/UHF transmitters to study their home range size, movement and habitat use in an urban–forest mosaic in Eshowe, South Africa from March to October 2014. We estimated the home range size using three methods: minimum convex polygon (MCP), kernel density estimation (KDE) and local convex hull (LoCoH). Our results showed that overall monthly home range size was 5.1 ± 1.28 km<sup>2</sup> (mean ± SE; 95% MCP), 4.6 ± 1.14 km<sup>2</sup> (95% KDE) and 1.9 ± 0. 46 km<sup>2</sup> (95% LoCoH). However, individual home range sizes varied monthly and seasonally. We found that all individuals tagged used mostly the indigenous forest and frequently utilised urban residential areas (gardens) with little or no use of cultivated land. Observed individual variations in monthly and seasonal home ranges could be a response to variations in availability of key fruit resources in the urban residential and indigenous forest mosaic. This study supports the use of more than one method of home range estimation for insight regarding home range and habitat use in urban–forest mosaics for this large forest frugivore.
DOI: 10.6084/m9.figshare.4898144
title: Multilanguage Written Picture Naming Dataset

description: Timed naming data in 14 European languages for pictures in the Rossion and Pourtois (2004) colourised version of the Snodgrass and Vanderwart (1980) set of pictures of 260 everyday objects. For each language we provide by-picture "norms", including name and spelling diversity, response time and mean interkey-interval. We also provide the by-trial data from which these were derived. Please see the Readme file for more details and <br>Torrance, M., Nottbusch, G., Alves, R. A., Arfé, B., Chanquoy, L., Chukharev-Hudilainen, E., … Wengelin, Å. (2017). Timed written picture naming in 14 European languages. <i>Behavior Research Methods</i>. http://doi.org/10.3758/s13428-017-0902-xfor a full explanation (open access).<br>