cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.13004306
title: Additional file 9 of Genome-wide association studies of ionomic and agronomic traits in USDA mini core collection of rice and comparative analyses of different mapping methods

description: Additional file 9: Supplementary Table 2. The QTLs associated with agronomic traits, ionomic in flooded and unflooded conditions with four different methods.
DOI: 10.6084/m9.figshare.13004306.v1
title: Additional file 9 of Genome-wide association studies of ionomic and agronomic traits in USDA mini core collection of rice and comparative analyses of different mapping methods

description: Additional file 9: Supplementary Table 2. The QTLs associated with agronomic traits, ionomic in flooded and unflooded conditions with four different methods.
DOI: 10.6084/m9.figshare.11955750
title: Efficacy of the sphingosine-1-phosphate receptor agonist fingolimod in animal models of stroke: an updated meta-analysis

description: <b>Objective:</b> Neuroinflammation is a central part of cerebral ischemia/reperfusion injury. The novel immune suppressant, fingolimod, is a promising candidate to ameliorate stroke-induced damage. Fingolimod is efficacious in experimental ischemic models, but a rigorous meta-analysis is lacking that considers how different experiment variables affect outcomes. <b>Methods:</b> We conducted a systematic literature review of fingolimod in stroke models, with the aim of rigorously evaluating fingolimod’s effects on reducing infarct volume improving neurological outcomes. Seventeen variables were evaluated as covariates for the source of heterogeneity, and effect sizes were combined by using normalized mean difference meta-analysis to evaluate efficacy. Study quality was evaluated by the CAMARADES ten-item checklist, and publication bias was evaluated by funnel plots and Egger’s tests. <b>Results:</b> About 123 unduplicated articles were identified in the literature research. Of these papers, 118 articles were excluded after reading titles and abstracts. Another 17 articles were selected in this study. Study quality was moderate (median = 6; interquartile range = 4), and publication bias was statistically insignificant. fingolimod reduced infarct volume by 30.4% (95% CI 22.4%−38.3%; <i>n</i> = 24; I<sup>2</sup> = 90.0%; <i>p</i> &lt; 0.0001) and consistently enhanced neurobehavioral outcome by 34.2% (95% CI 23.1%−45.2%; <i>n</i> = 14; I<sup>2</sup> = 76.5%; <i>p</i> &lt; 0.0001). No single factors accounted for heterogeneity. <b>Conclusions:</b> Our rigorous statistical evaluation confirmed the neuroprotective properties of fingolimod. New data can be used in designing future clinical trials.
DOI: 10.6084/m9.figshare.11955750.v1
title: Efficacy of the sphingosine-1-phosphate receptor agonist fingolimod in animal models of stroke: an updated meta-analysis

description: <b>Objective:</b> Neuroinflammation is a central part of cerebral ischemia/reperfusion injury. The novel immune suppressant, fingolimod, is a promising candidate to ameliorate stroke-induced damage. Fingolimod is efficacious in experimental ischemic models, but a rigorous meta-analysis is lacking that considers how different experiment variables affect outcomes. <b>Methods:</b> We conducted a systematic literature review of fingolimod in stroke models, with the aim of rigorously evaluating fingolimod’s effects on reducing infarct volume improving neurological outcomes. Seventeen variables were evaluated as covariates for the source of heterogeneity, and effect sizes were combined by using normalized mean difference meta-analysis to evaluate efficacy. Study quality was evaluated by the CAMARADES ten-item checklist, and publication bias was evaluated by funnel plots and Egger’s tests. <b>Results:</b> About 123 unduplicated articles were identified in the literature research. Of these papers, 118 articles were excluded after reading titles and abstracts. Another 17 articles were selected in this study. Study quality was moderate (median = 6; interquartile range = 4), and publication bias was statistically insignificant. fingolimod reduced infarct volume by 30.4% (95% CI 22.4%−38.3%; <i>n</i> = 24; I<sup>2</sup> = 90.0%; <i>p</i> &lt; 0.0001) and consistently enhanced neurobehavioral outcome by 34.2% (95% CI 23.1%−45.2%; <i>n</i> = 14; I<sup>2</sup> = 76.5%; <i>p</i> &lt; 0.0001). No single factors accounted for heterogeneity. <b>Conclusions:</b> Our rigorous statistical evaluation confirmed the neuroprotective properties of fingolimod. New data can be used in designing future clinical trials.
DOI: 10.6084/m9.figshare.14052897
title: Additional file 1 of Spatiotemporal characteristics and meteorological determinants of hand, foot and mouth disease in Shaanxi Province, China: a county-level analysis

description: Additional file 1.
DOI: 10.6084/m9.figshare.14052897.v1
title: Additional file 1 of Spatiotemporal characteristics and meteorological determinants of hand, foot and mouth disease in Shaanxi Province, China: a county-level analysis

description: Additional file 1.
DOI: 10.6084/m9.figshare.14577198
title: The characterization of metabolites alterations in white adipose tissue of diabetic GK Rats after ileal transposition surgery by an untargeted metabolomics approach

description: Dysfunction of adipose tissue could lead to insulin resistance, obesity and type 2 diabetes. Thus, our present study aimed to investigate metabolites alterations in white adipose tissue (WAT) of diabetic GK rats after IT surgery. Ten-week-old male diabetic GK rats were randomly subjected to IT and Sham-IT surgery. Six weeks later, the untargeted metabolomics in WAT of diabetic GK rats was performed. Differential metabolites were selected according to the coefficient of variation (CV) of quality control (QC) sample &lt;30%, variable importance in the projection (VIP) &gt;1 and P &lt; 0.05. Then, the hierarchical clustering of differential metabolites was conducted and the KEGG database was used for metabolic pathway analysis. A total of 50 (in positive ion mode) and 68 (in negative ion mode) metabolites were identified as differential metabolites in WAT of diabetic GK rats between IT group and Sham-IT group, respectively. These differential metabolites were well clustered, which in descending order of the number of involved differential metabolites is ubiquinone and other terpenoid-quinone biosynthesis, AMPK signalling pathway, pantothenate and CoA biosynthesis, ferroptosis, vitamin digestion and absorption, glycerophospholipid metabolism, phenylalanine metabolism, steroid hormone biosynthesis, neuroactive ligand–receptor interaction, porphyrin and chlorophyll metabolism and bile secretion, and correlated with the parameters of body weight, food intake, WAT mass and glucose metabolism, which were significantly improved after IT surgery. The differential metabolites in WAT of diabetic GK rats were mainly related to the pathway of energy metabolism, and correlated with the improved phenotypes of diabetic GK rats after IT surgery.
DOI: 10.6084/m9.figshare.14577198.v1
title: The characterization of metabolites alterations in white adipose tissue of diabetic GK Rats after ileal transposition surgery by an untargeted metabolomics approach

description: Dysfunction of adipose tissue could lead to insulin resistance, obesity and type 2 diabetes. Thus, our present study aimed to investigate metabolites alterations in white adipose tissue (WAT) of diabetic GK rats after IT surgery. Ten-week-old male diabetic GK rats were randomly subjected to IT and Sham-IT surgery. Six weeks later, the untargeted metabolomics in WAT of diabetic GK rats was performed. Differential metabolites were selected according to the coefficient of variation (CV) of quality control (QC) sample &lt;30%, variable importance in the projection (VIP) &gt;1 and P &lt; 0.05. Then, the hierarchical clustering of differential metabolites was conducted and the KEGG database was used for metabolic pathway analysis. A total of 50 (in positive ion mode) and 68 (in negative ion mode) metabolites were identified as differential metabolites in WAT of diabetic GK rats between IT group and Sham-IT group, respectively. These differential metabolites were well clustered, which in descending order of the number of involved differential metabolites is ubiquinone and other terpenoid-quinone biosynthesis, AMPK signalling pathway, pantothenate and CoA biosynthesis, ferroptosis, vitamin digestion and absorption, glycerophospholipid metabolism, phenylalanine metabolism, steroid hormone biosynthesis, neuroactive ligand–receptor interaction, porphyrin and chlorophyll metabolism and bile secretion, and correlated with the parameters of body weight, food intake, WAT mass and glucose metabolism, which were significantly improved after IT surgery. The differential metabolites in WAT of diabetic GK rats were mainly related to the pathway of energy metabolism, and correlated with the improved phenotypes of diabetic GK rats after IT surgery.
DOI: 10.6084/m9.figshare.13004341
title: Additional file 2 of GeneMates: an R package for detecting horizontal gene co-transfer between bacteria using gene-gene associations controlled for population structure

description: Additional file 2 An Excel spreadsheet of sample information, including database accessions, sampling locations and years, sequencing layout, and so forth. It consists of four tables with names Ecoli_reads (Illumina read sets of E. coli isolates), STyphimurium_reads (Illumina read sets of Salmonella isolates), MDR_Ecoli_ref (GenBank records for complete genomes of 10 multidrug-resistant E. coli isolates), and MDR_STyphimurium_ref (GenBank records for complete genomes of 10 multidrug-resistant S. Typhimurium isolates).
DOI: 10.6084/m9.figshare.13004341.v1
title: Additional file 2 of GeneMates: an R package for detecting horizontal gene co-transfer between bacteria using gene-gene associations controlled for population structure

description: Additional file 2 An Excel spreadsheet of sample information, including database accessions, sampling locations and years, sequencing layout, and so forth. It consists of four tables with names Ecoli_reads (Illumina read sets of E. coli isolates), STyphimurium_reads (Illumina read sets of Salmonella isolates), MDR_Ecoli_ref (GenBank records for complete genomes of 10 multidrug-resistant E. coli isolates), and MDR_STyphimurium_ref (GenBank records for complete genomes of 10 multidrug-resistant S. Typhimurium isolates).
DOI: 10.6084/m9.figshare.13004344
title: Additional file 3 of GeneMates: an R package for detecting horizontal gene co-transfer between bacteria using gene-gene associations controlled for population structure

description: Additional file 3 An Excel spreadsheet about prophages identified in reference chromosome sequences and statistics of read mapping and de novo genome assemblies.
DOI: 10.6084/m9.figshare.13004344.v1
title: Additional file 3 of GeneMates: an R package for detecting horizontal gene co-transfer between bacteria using gene-gene associations controlled for population structure

description: Additional file 3 An Excel spreadsheet about prophages identified in reference chromosome sequences and statistics of read mapping and de novo genome assemblies.
DOI: 10.34740/kaggle/dsv/7687902
title: Smoking Crisis
DOI: 10.6084/m9.figshare.17198708
title: Hypermethylation of the <i>OPRM1</i> and <i>ALDH2</i> promoter regions in Chinese Han males with alcohol use disorder in Yunnan Province

description: Alcohol use disorder (AUD) is one of the most serious public health problems worldwide. The <i>OPRM1</i> and <i>ALDH2</i> genes are important factors in the reward and alcohol metabolism pathways, and their DNA methylation patterns are closely related to AUD and are population-specific. Chinese Han people are the most populous ethnic group in the world, and this group experiences severe AUD. No epigenetic study on <i>OPRM1</i> and <i>ALDH2</i> has been performed in Chinese Han patients with AUD. To investigate whether methylation patterns of <i>OPRM1</i> and <i>ALDH2</i> are associated with susceptibility to AUD in Chinese Han males. DNA methylation of the <i>OPRM1</i> and <i>ALDH2</i> promoters was studied in Chinese Han males with AUD in Yunnan Province (N = 50 controls, N = 90 individuals with AUD) using the bisulfite pyrosequencing method. 
In the AUD group, compared with the control group, OPRM1 was hypermethylated(p &lt; .01) but there was no significant difference in the methylation level of ALDH2 (p &gt; .05). 9 CpG sites of OPRM1 (p &lt; .05) and 2 CpG sites of ALDH2 (p &gt; .01) were hypermethylated. Smoking promoted AUD-mediated hypermethylation of <i>OPRM1</i>, in which 3 CpG sites showed significant hypermethylation (<i>p</i> &lt; .01). Age had no significant effect on the DNA methylation levels of these two genes. 
Our study demonstrates that DNA hypermethylation of the <i>OPRM1</i> and <i>ALDH2</i> promoter regions is associated with an increased risk of AUD, which may help to explain the pathogenesis and progression of AUD.
DOI: 10.6084/m9.figshare.17198708.v1
title: Hypermethylation of the <i>OPRM1</i> and <i>ALDH2</i> promoter regions in Chinese Han males with alcohol use disorder in Yunnan Province

description: Alcohol use disorder (AUD) is one of the most serious public health problems worldwide. The <i>OPRM1</i> and <i>ALDH2</i> genes are important factors in the reward and alcohol metabolism pathways, and their DNA methylation patterns are closely related to AUD and are population-specific. Chinese Han people are the most populous ethnic group in the world, and this group experiences severe AUD. No epigenetic study on <i>OPRM1</i> and <i>ALDH2</i> has been performed in Chinese Han patients with AUD. To investigate whether methylation patterns of <i>OPRM1</i> and <i>ALDH2</i> are associated with susceptibility to AUD in Chinese Han males. DNA methylation of the <i>OPRM1</i> and <i>ALDH2</i> promoters was studied in Chinese Han males with AUD in Yunnan Province (N = 50 controls, N = 90 individuals with AUD) using the bisulfite pyrosequencing method. 
In the AUD group, compared with the control group, OPRM1 was hypermethylated(p &lt; .01) but there was no significant difference in the methylation level of ALDH2 (p &gt; .05). 9 CpG sites of OPRM1 (p &lt; .05) and 2 CpG sites of ALDH2 (p &gt; .01) were hypermethylated. Smoking promoted AUD-mediated hypermethylation of <i>OPRM1</i>, in which 3 CpG sites showed significant hypermethylation (<i>p</i> &lt; .01). Age had no significant effect on the DNA methylation levels of these two genes. 
Our study demonstrates that DNA hypermethylation of the <i>OPRM1</i> and <i>ALDH2</i> promoter regions is associated with an increased risk of AUD, which may help to explain the pathogenesis and progression of AUD.
DOI: 10.6084/m9.figshare.12480128
title: Additional file 5 of PHGDH supports liver ceramide synthesis and sustains lipid homeostasis

description: Additional file 5: Supplementary Table 1. Analysis parameters for targeted lipidomics.
DOI: 10.6084/m9.figshare.12480128.v1
title: Additional file 5 of PHGDH supports liver ceramide synthesis and sustains lipid homeostasis

description: Additional file 5: Supplementary Table 1. Analysis parameters for targeted lipidomics.
DOI: 10.6084/m9.figshare.12480131
title: Additional file 6 of PHGDH supports liver ceramide synthesis and sustains lipid homeostasis

description: Additional file 6: Supplementary Table 2. Lipidomics data from Figure5A. Lipidomics analysis of shPHGDH (N = 11) serum compared to shREN (N = 12).
DOI: 10.6084/m9.figshare.12480131.v1
title: Additional file 6 of PHGDH supports liver ceramide synthesis and sustains lipid homeostasis

description: Additional file 6: Supplementary Table 2. Lipidomics data from Figure5A. Lipidomics analysis of shPHGDH (N = 11) serum compared to shREN (N = 12).
DOI: 10.6084/m9.figshare.12480134
title: Additional file 7 of PHGDH supports liver ceramide synthesis and sustains lipid homeostasis

description: Additional file 7: Supplementary Table 3. Lipidomics data from Figure5B. Lipidomics analysis of shPHGDH (N = 11) liver compared to shREN (N = 11).
DOI: 10.6084/m9.figshare.12480134.v1
title: Additional file 7 of PHGDH supports liver ceramide synthesis and sustains lipid homeostasis

description: Additional file 7: Supplementary Table 3. Lipidomics data from Figure5B. Lipidomics analysis of shPHGDH (N = 11) liver compared to shREN (N = 11).
DOI: 10.6084/m9.figshare.12480137
title: Additional file 8 of PHGDH supports liver ceramide synthesis and sustains lipid homeostasis

description: Additional file 8: Supplementary Table 4. Lipidomics data from Supplementary Figure4C. Lipidomics analysis of shPHGDH (N = 15) brain compared to shREN (N = 14).
DOI: 10.6084/m9.figshare.12480137.v1
title: Additional file 8 of PHGDH supports liver ceramide synthesis and sustains lipid homeostasis

description: Additional file 8: Supplementary Table 4. Lipidomics data from Supplementary Figure4C. Lipidomics analysis of shPHGDH (N = 15) brain compared to shREN (N = 14).
DOI: 10.25549/impa-c123-89394
title: Rev. Henry Rusillon

description: Rev. Henry Rusillon ; Portrait of Rev. Henry Rusillon (1872-1938), a missionary of the Société des missions évangéliques de Paris (Paris evangelical missionary society), sent to Madagascar from 1897 to 1928.
DOI: 10.25549/impa-c123-89395
title: Adolphe Jalla

description: Adolphe Jalla ; Portrait of Adolphe Jalla (1864-1946), a missionary of the Société des missions évangéliques de Paris (Paris evangelical missionary society), sent to Barotseland from 1889 to 1946.
DOI: 10.25549/impa-c123-89396
title: F. H. Krüger

description: F. H. Krüger ; Portrait of F. H. Krüger (1851-1900), a missionary of the Société des missions évangéliques de Paris (Paris evangelical missionary society) sent to Basutoland as pastor from 1882 to 1883. He become Director of the École des Missions (a missionary training institution) in Paris from 1884 to his death.
DOI: 10.25549/impa-c123-89397
title: Portrait of PEMS missionary Paul Ramseyer

description: Portrait of PEMS missionary, Paul Ramseyer ; Comment : Paul Ramseyer (1870-1929) was a missionary of the Société des missions évangéliques de Paris (Paris evangelical missionary society), sent to Barotseland and to Basutoland.
DOI: 10.25549/impa-c123-89398
title: Maurice Robert

description: Maurice Robert ; Portrait of Rev. Maurice Robert (1878-1913), a missionary of the Société des missions évangéliques de Paris (Paris evangelical missionary society) sent to Gabon from 1902 to 1911.
DOI: 10.25549/impa-c123-89399
title: Reverend Joseph Rabetafika

description: Reverend Joseph Rabetafika
DOI: 10.5517/ccdc.csd.cc224p53
title: CCDC 1911124: Experimental Crystal Structure Determination

description: Related Article: Yoshiki Sasaki, Masayoshi Takase, Nagao Kobayashi, Shigeki Mori, Keishi Ohara, Tetsuo Okujima, Hidemitsu Uno|2021|J.Org.Chem.|86|4290|doi:10.1021/acs.joc.0c02825
DOI: 10.25549/impa-c123-89400
title: Razafimahefa

description: Razafimahefa ; Portrait of a Malagasy pastor, Razafimahefa Rainy (1867-1961)
DOI: 10.5517/ccdc.csd.cc224p64
title: CCDC 1911125: Experimental Crystal Structure Determination

description: Related Article: Yoshiki Sasaki, Masayoshi Takase, Nagao Kobayashi, Shigeki Mori, Keishi Ohara, Tetsuo Okujima, Hidemitsu Uno|2021|J.Org.Chem.|86|4290|doi:10.1021/acs.joc.0c02825
DOI: 10.25549/impa-c123-89401
title: Mrs L. Jacottet

description: Mrs L. Jacottet ; Portrait of Mrs L. Jacottet (Born Barrelet), wife of Rev. Édouard Jacottet, a missionary of the Société des missions évangéliques de Paris (Paris evangelical missionary society) sent to Basutoland.
DOI: 10.5517/ccdc.csd.cc224p75
title: CCDC 1911126: Experimental Crystal Structure Determination

description: Related Article: Yoshiki Sasaki, Masayoshi Takase, Nagao Kobayashi, Shigeki Mori, Keishi Ohara, Tetsuo Okujima, Hidemitsu Uno|2021|J.Org.Chem.|86|4290|doi:10.1021/acs.joc.0c02825
DOI: 10.25549/impa-c123-89402
title: Mrs Louis Jalla, who died in 1899

description: Mrs Louis Jalla, who died in 1899 ; Portrait of Marie (Born Turin), the first wife of PEMS missionary Louis Jalla.
DOI: 10.25549/impa-c123-89403
title: Mr and Mrs Adolphe Jalla

description: Mr and Mrs Adolphe Jalla ; Adolphe Jalla (1864-1946) was a missionary of the Société des missions évangéliques de Paris (Paris evangelical missionary society), sent to Barotseland from 1889 to 1946. Here he was with his first wife Emma (Born Pons).
DOI: 10.25549/impa-c123-89404
title: Dr Jeanmairet

description: Dr Jeanmairet ; Portrait of Dorwald Jeanmairet (1856-1942), a missionary of the Société des missions évangéliques de Paris (Paris evangelical missionary society) sent to Barotseland and Basutoland as pastor from 1883.
DOI: 10.25549/impa-c123-89405
title: Théophile Jousse, missionary in Lesotho

description: Théophile Jousse, missionary in Lesotho ; Portrait of Rev. Théophile Jousse (1823-1890). He was missionary to Lesotho from 1850 to 1882. He became Acting Director of the Société des missions évangéliques de Paris (Paris evangelical missionary society) from 1883.
DOI: 10.25549/impa-c123-89406
title: Mrs Jousse

description: Mrs Jousse ; Portrait of Mrs Clémentine Jousse (Born Gilet), the wife of Rev. Théophile Jousse (Missionary to Lesotho, Acting Director of the Société des missions évangéliques de Paris (Paris evangelical missionary society).
DOI: 10.25549/impa-c123-89407
title: Théophile Jousse

description: Théophile Jousse ; Portrait of Rev. Théophile Jousse (1823-1890). He was missionary to Lesotho from 1850 to 1882. He became Acting Director of the Société des missions évangéliques de Paris (Paris evangelical missionary society) from 1883. ; Use of document : Photograph published in "Le livre d'or de la mission au Lessouto, SMEP, 1912", p. 227.
DOI: 10.25549/impa-c123-89408
title: Mrs Jousse

description: Mrs Jousse ; Portrait of Mrs Clémentine Jousse (Born Gilet), the wife of Rev. Théophile Jousse (Missionary to Lesotho, Acting Director of the Société des missions évangéliques de Paris (Paris evangelical missionary society).
DOI: 10.25549/impa-c123-89409
title: Miss Elise Kiener (left Paris to Barotseland on February 17th, 1890)

description: Miss Elise Kiener (left Paris to Barotseland on February 17th, 1890) ; Miss Kiener was a teacher, sent by the Société des missions évangéliques de Paris (Paris evangelical missionary society) to Barotseland from 1890 to 1919.
DOI: 10.25549/impa-c123-89410
title: Miss Kiener

description: Miss Kiener ; Miss Kiener was a teacher, sent by the Société des missions évangéliques de Paris (Paris evangelical missionary society) to Barotseland from 1890 to 1919.
DOI: 10.25549/impa-c123-89411
title: PEMS missionary Louis Jalla

description: PEMS missionary Louis Jalla ; Portrait of Louis Jalla (1860-1943), a missionary of the Société des missions évangéliques de Paris (Paris evangelical missionary society), sent to Barotseland in Sesheké and Mazungula from 1886 to 1931.
DOI: 10.5517/ccdc.csd.cc2724cv
title: CCDC 2057636: Experimental Crystal Structure Determination

description: Related Article: Jun-Xia Li, Tian Zhang, He-Jun Chen, Zhong-Xiang Du|2021|Z.Krist.Cryst.Mater.|236|251|doi:10.1515/zkri-2021-2043
DOI: 10.25549/impa-c123-89412
title: Hermann Dieterlen, left for Africa on October, 1874

description: Hermann Dieterlen, left for Africa on October, 1874 ; Portrait of Hermann Dieterlen (1850-1933), a missionary of the Société des missions évangéliques de Paris (Paris evangelical missionary society), sent to Basutoland from 1874 to 1919.
DOI: 10.25549/impa-c123-89413
title: Robert Pearsall Smith

description: Robert Pearsall Smith
DOI: 10.25549/impa-c123-89414
title: Robert Pearsall Smith

description: Robert Pearsall Smith ; Robert Pearsall Smith (1827-1899),a lay leader in the Holiness movement.
DOI: 10.25549/impa-c123-89415
title: Émile Vollet

description: Émile Vollet ; Portrait of Émile Vollet (1862-1927), a missionary of the Société des missions évangéliques de Paris (Paris evangelical missionary society), sent to Barotseland and then to Basutoland.