cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.19920883
title: LASER in periodontal treatment: is it an effective treatment or science fiction?

description: Abstract There are several studies that evaluate the use of lasers in periodontal treatment in non-surgical or surgical therapy. However, while several studies showed clinically beneficial effects of some lasers in periodontal treatment, there are few clinical reports of additional advantages of lasers as adjunctive treatments in periodontology. The aim of this paper is to demonstrate and critically analyze the level of scientific evidence of effects of low-level lasers and high-power lasers in periodontology. A narrative review of the studies was carried out in each topic and type of laser or periodontal treatment. In nonsurgical periodontal therapy the results showed that there is an additional clinical benefit when using a diode laser (DL) associated with scaling and root planing (SRP) in patients with moderate to severe periodontitis. The Er:YAG laser seems to be the most suitable for nonsurgical periodontal therapy and promotes the same clinical effects as conventional therapy. In periodontal surgery vaporization of the gingival or mucosal tissue can be carried out with DL, CO2, Nd:YAG, Er:YAG and Er,Cr:YSGG lasers. Photobiomodulation (PBM), mediated by low-level lasers associated with non-surgical periodontal therapy, promotes additional benefits in the short term and accelerates the bone and gingival tissue repair process and also reduces postoperative symptoms of periodontal surgery. The effect of antimicrobial Photodynamic Therapy is relevant in the initial reevaluation periods. Studies have shown controversial results of the use of lasers in periodontics, and this fact may be due to the lack of standard parameters of irradiation in each clinical application.
DOI: 10.6084/m9.figshare.19920883.v1
title: LASER in periodontal treatment: is it an effective treatment or science fiction?

description: Abstract There are several studies that evaluate the use of lasers in periodontal treatment in non-surgical or surgical therapy. However, while several studies showed clinically beneficial effects of some lasers in periodontal treatment, there are few clinical reports of additional advantages of lasers as adjunctive treatments in periodontology. The aim of this paper is to demonstrate and critically analyze the level of scientific evidence of effects of low-level lasers and high-power lasers in periodontology. A narrative review of the studies was carried out in each topic and type of laser or periodontal treatment. In nonsurgical periodontal therapy the results showed that there is an additional clinical benefit when using a diode laser (DL) associated with scaling and root planing (SRP) in patients with moderate to severe periodontitis. The Er:YAG laser seems to be the most suitable for nonsurgical periodontal therapy and promotes the same clinical effects as conventional therapy. In periodontal surgery vaporization of the gingival or mucosal tissue can be carried out with DL, CO2, Nd:YAG, Er:YAG and Er,Cr:YSGG lasers. Photobiomodulation (PBM), mediated by low-level lasers associated with non-surgical periodontal therapy, promotes additional benefits in the short term and accelerates the bone and gingival tissue repair process and also reduces postoperative symptoms of periodontal surgery. The effect of antimicrobial Photodynamic Therapy is relevant in the initial reevaluation periods. Studies have shown controversial results of the use of lasers in periodontics, and this fact may be due to the lack of standard parameters of irradiation in each clinical application.
DOI: 10.6084/m9.figshare.19920915
title: Rethinking the decision-making process to treat gingival recession associated with non-carious cervical lesions

description: Abstract The presence of a tooth-surface defect, such as a non-carious cervical lesion (NCCL), associated with sites of gingival recession (GR) defects creates a combined soft tissue/tooth defect (CD) that requires a different treatment plan. This study aimed to critically review the literature regarding the available treatment protocols for CDs and suggest a new decision-making process. NCCLs were classified as Class A-: the cementoenamel junction (CEJ) was visible and the root surface discrepancy was &lt; 0.5 mm (no step); Class A+: CEJ was visible and the root surface discrepancy was &gt; 0.5 mm (with a step); Class B-: unidentiﬁable CEJ without a step; Class B+: unidentiﬁable CEJ with a step. NCCLs affecting both root and crown surfaces (Class B) lead to CEJ destruction and consequently eliminate an important landmark used before and after root coverage procedures. The depth of the root surface discrepancy is vital owing to its possible impact on soft tissue adaptation after healing, which, in turn, may influence the treatment options, namely the use of graft and/or composites to compensate for the discrepancy. Clinically, a step with horizontal depth greater than 0.5 mm should be recognized as the minimum threshold value to define this condition. Extremely deep defects tend to assume a V-shaped topography. Therefore, extremely deep V-shaped defects were classified into subclasses A+V, a V-shaped defect, and B+V, a V-shaped defect with loss of CEJ, for management considerations. The treatment options, supported by the literature, and a decision-making process to deal with each condition are presented.
DOI: 10.6084/m9.figshare.19920915.v1
title: Rethinking the decision-making process to treat gingival recession associated with non-carious cervical lesions

description: Abstract The presence of a tooth-surface defect, such as a non-carious cervical lesion (NCCL), associated with sites of gingival recession (GR) defects creates a combined soft tissue/tooth defect (CD) that requires a different treatment plan. This study aimed to critically review the literature regarding the available treatment protocols for CDs and suggest a new decision-making process. NCCLs were classified as Class A-: the cementoenamel junction (CEJ) was visible and the root surface discrepancy was &lt; 0.5 mm (no step); Class A+: CEJ was visible and the root surface discrepancy was &gt; 0.5 mm (with a step); Class B-: unidentiﬁable CEJ without a step; Class B+: unidentiﬁable CEJ with a step. NCCLs affecting both root and crown surfaces (Class B) lead to CEJ destruction and consequently eliminate an important landmark used before and after root coverage procedures. The depth of the root surface discrepancy is vital owing to its possible impact on soft tissue adaptation after healing, which, in turn, may influence the treatment options, namely the use of graft and/or composites to compensate for the discrepancy. Clinically, a step with horizontal depth greater than 0.5 mm should be recognized as the minimum threshold value to define this condition. Extremely deep defects tend to assume a V-shaped topography. Therefore, extremely deep V-shaped defects were classified into subclasses A+V, a V-shaped defect, and B+V, a V-shaped defect with loss of CEJ, for management considerations. The treatment options, supported by the literature, and a decision-making process to deal with each condition are presented.
DOI: 10.6084/m9.figshare.19920955.v1
title: Randomized clinical trials in periodontology: focus on outcomes selection

description: Abstract Randomized clinical trials (RCTs) are human studies carried out to compare different treatments or interventions, and their results are used to support clinical decision-making and improve patient care. Herein, the aim of this study was to review the selection process of study outcomes in periodontology. Primary outcomes should draw the main conclusions of the study, whereas secondary outcomes should only be used to help explain the main findings and generate future research hypothesis. Outcomes are classified as clinically relevant (CROs) or surrogate outcomes. CROs – the first option for primary outcome variables - should convey not only substantial health benefits, but also be deemed important by patients. In periodontology, tooth loss/retention and oral health–related quality of life (OHRQoL) are examples of CROs. While tooth loss has main limitations as a primary outcome, emerging evidence suggest that patient-reported outcome measures (PROMs) can accurately detect OHRQoL following periodontal therapy. When CROs cannot be assessed, validated surrogate outcomes can be used as proxies. Primary outcome variables should reflect a treatment endpoint at the patient level that can be easily used to inform decision-making in daily practice. These outcomes should allow the implementation of a treat-to-target concept in which the intervention can be clearly judged against a prespecified treatment target. Recently, the presence of at most 4 sites with periodontal probing depth ≥5 mm post-treatment was suggested as an effective endpoint for periodontal trials. In perspective, a combination of validated clinical parameters and PROMs will provide a more comprehensive assessment of periodontal treatments.
DOI: 10.6084/m9.figshare.19920955
title: Randomized clinical trials in periodontology: focus on outcomes selection

description: Abstract Randomized clinical trials (RCTs) are human studies carried out to compare different treatments or interventions, and their results are used to support clinical decision-making and improve patient care. Herein, the aim of this study was to review the selection process of study outcomes in periodontology. Primary outcomes should draw the main conclusions of the study, whereas secondary outcomes should only be used to help explain the main findings and generate future research hypothesis. Outcomes are classified as clinically relevant (CROs) or surrogate outcomes. CROs – the first option for primary outcome variables - should convey not only substantial health benefits, but also be deemed important by patients. In periodontology, tooth loss/retention and oral health–related quality of life (OHRQoL) are examples of CROs. While tooth loss has main limitations as a primary outcome, emerging evidence suggest that patient-reported outcome measures (PROMs) can accurately detect OHRQoL following periodontal therapy. When CROs cannot be assessed, validated surrogate outcomes can be used as proxies. Primary outcome variables should reflect a treatment endpoint at the patient level that can be easily used to inform decision-making in daily practice. These outcomes should allow the implementation of a treat-to-target concept in which the intervention can be clearly judged against a prespecified treatment target. Recently, the presence of at most 4 sites with periodontal probing depth ≥5 mm post-treatment was suggested as an effective endpoint for periodontal trials. In perspective, a combination of validated clinical parameters and PROMs will provide a more comprehensive assessment of periodontal treatments.
DOI: 10.6084/m9.figshare.19920972
title: Additional file 10 of De novo transcriptome assembly of the cotyledon of Camellia oleifera for discovery of genes regulating seed germination

description: Additional file 10: Table S9. The functional annotation of all modules in WGCNA.
DOI: 10.6084/m9.figshare.19920975.v1
title: Additional file 11 of De novo transcriptome assembly of the cotyledon of Camellia oleifera for discovery of genes regulating seed germination

description: Additional file 11: Table S10. The function of 50 most highly connected hub genes in the MEyellow module.
DOI: 10.6084/m9.figshare.19920972.v1
title: Additional file 10 of De novo transcriptome assembly of the cotyledon of Camellia oleifera for discovery of genes regulating seed germination

description: Additional file 10: Table S9. The functional annotation of all modules in WGCNA.
DOI: 10.6084/m9.figshare.19920975
title: Additional file 11 of De novo transcriptome assembly of the cotyledon of Camellia oleifera for discovery of genes regulating seed germination

description: Additional file 11: Table S10. The function of 50 most highly connected hub genes in the MEyellow module.
DOI: 10.6084/m9.figshare.19920981.v1
title: Additional file 13 of De novo transcriptome assembly of the cotyledon of Camellia oleifera for discovery of genes regulating seed germination

description: Additional file 13: Table S12. Primer sequence used in qRT-PCR analysis.
DOI: 10.6084/m9.figshare.19920978
title: Additional file 12 of De novo transcriptome assembly of the cotyledon of Camellia oleifera for discovery of genes regulating seed germination

description: Additional file 12: Table S11. The content of hormone in seeds of C.oleifera.
DOI: 10.6084/m9.figshare.19920981
title: Additional file 13 of De novo transcriptome assembly of the cotyledon of Camellia oleifera for discovery of genes regulating seed germination

description: Additional file 13: Table S12. Primer sequence used in qRT-PCR analysis.
DOI: 10.6084/m9.figshare.19920990.v1
title: Additional file 3 of De novo transcriptome assembly of the cotyledon of Camellia oleifera for discovery of genes regulating seed germination

description: Additional file 3. Table S2. Statistics of sample sequencing data evaluation and assembly results.
DOI: 10.6084/m9.figshare.19920978.v1
title: Additional file 12 of De novo transcriptome assembly of the cotyledon of Camellia oleifera for discovery of genes regulating seed germination

description: Additional file 12: Table S11. The content of hormone in seeds of C.oleifera.
DOI: 10.6084/m9.figshare.19920987
title: Additional file 2 of De novo transcriptome assembly of the cotyledon of Camellia oleifera for discovery of genes regulating seed germination

description: Additional file 2: Table S1. Sequencing statistics of the transcriptome from five stages.
DOI: 10.6084/m9.figshare.19920984.v1
title: Additional file 1 of De novo transcriptome assembly of the cotyledon of Camellia oleifera for discovery of genes regulating seed germination

description: Additional file 1: Fig. S1. Species distribution of top BLAST hits for matched unigenes sequences. Percentage of unigenes matching the top nine species using Blastx in the NR database. Fig. S2. Principal component analysis (PCA) of all samples. Each color on the right indicates the meaning of legend. Fig. S3. Histogram presentation of GO classification in different genes. 6820 DEGs were matched by GO terms of three categories. Biological process (blue), Cellular component (green), Molecular function (red). Fig. S4. Classification of different genes in the KEGG pathway. The X-axis represents the value of rich factors (the ratio of annotated DEGs to all genes of the enriched pathway). The Y-axis represents the names of pathways. The color depth of each point represents q value. The size of each point represents the number of DEGs. (A) KEGG annotation of DEGs of CAM2 vs. CAM0. (B) KEGG annotation of DEGs of CAM4S vs. CAM2. (C) KEGG annotation of DEGs of CAM6S vs. CAM4S. (D) KEGG annotation of DEGs of CAM26S vs. CAM6S. (E) KEGG annotation of DEGs of CAM6S vs. CAM0. (F) KEGG annotation of DEGs of CAM4S vs. CAM0. (G) KEGG annotation of DEGs of CAM26S vs. CAM0. Fig. S5. The differential expression of TFs across five stages. The differential expression of TFs was depicted in heatmap based on Z-score normalized TPM values. The green color indicates lower expressed genes, while the red indicates higher expressed genes.
DOI: 10.6084/m9.figshare.19920993.v1
title: Additional file 4 of De novo transcriptome assembly of the cotyledon of Camellia oleifera for discovery of genes regulating seed germination

description: Additional file 4: Table S3. Annotation statistics of unigenes in publicly available databases.
DOI: 10.6084/m9.figshare.19920999
title: Additional file 6 of De novo transcriptome assembly of the cotyledon of Camellia oleifera for discovery of genes regulating seed germination

description: Additional file 6: Table S5. The annotation in the eggNOG database.
DOI: 10.6084/m9.figshare.19920984
title: Additional file 1 of De novo transcriptome assembly of the cotyledon of Camellia oleifera for discovery of genes regulating seed germination

description: Additional file 1: Fig. S1. Species distribution of top BLAST hits for matched unigenes sequences. Percentage of unigenes matching the top nine species using Blastx in the NR database. Fig. S2. Principal component analysis (PCA) of all samples. Each color on the right indicates the meaning of legend. Fig. S3. Histogram presentation of GO classification in different genes. 6820 DEGs were matched by GO terms of three categories. Biological process (blue), Cellular component (green), Molecular function (red). Fig. S4. Classification of different genes in the KEGG pathway. The X-axis represents the value of rich factors (the ratio of annotated DEGs to all genes of the enriched pathway). The Y-axis represents the names of pathways. The color depth of each point represents q value. The size of each point represents the number of DEGs. (A) KEGG annotation of DEGs of CAM2 vs. CAM0. (B) KEGG annotation of DEGs of CAM4S vs. CAM2. (C) KEGG annotation of DEGs of CAM6S vs. CAM4S. (D) KEGG annotation of DEGs of CAM26S vs. CAM6S. (E) KEGG annotation of DEGs of CAM6S vs. CAM0. (F) KEGG annotation of DEGs of CAM4S vs. CAM0. (G) KEGG annotation of DEGs of CAM26S vs. CAM0. Fig. S5. The differential expression of TFs across five stages. The differential expression of TFs was depicted in heatmap based on Z-score normalized TPM values. The green color indicates lower expressed genes, while the red indicates higher expressed genes.
DOI: 10.6084/m9.figshare.19920996
title: Additional file 5 of De novo transcriptome assembly of the cotyledon of Camellia oleifera for discovery of genes regulating seed germination

description: Additional file 5: Table S4. The functional annotation of in unigenes.
DOI: 10.6084/m9.figshare.19920987.v1
title: Additional file 2 of De novo transcriptome assembly of the cotyledon of Camellia oleifera for discovery of genes regulating seed germination

description: Additional file 2: Table S1. Sequencing statistics of the transcriptome from five stages.
DOI: 10.6084/m9.figshare.19920999.v1
title: Additional file 6 of De novo transcriptome assembly of the cotyledon of Camellia oleifera for discovery of genes regulating seed germination

description: Additional file 6: Table S5. The annotation in the eggNOG database.
DOI: 10.6084/m9.figshare.19920990
title: Additional file 3 of De novo transcriptome assembly of the cotyledon of Camellia oleifera for discovery of genes regulating seed germination

description: Additional file 3. Table S2. Statistics of sample sequencing data evaluation and assembly results.
DOI: 10.6084/m9.figshare.19920993
title: Additional file 4 of De novo transcriptome assembly of the cotyledon of Camellia oleifera for discovery of genes regulating seed germination

description: Additional file 4: Table S3. Annotation statistics of unigenes in publicly available databases.
DOI: 10.6084/m9.figshare.19921005.v1
title: Additional file 7 of De novo transcriptome assembly of the cotyledon of Camellia oleifera for discovery of genes regulating seed germination

description: Additional file 7: Table S6. The different genes in each comparison.
DOI: 10.6084/m9.figshare.19921008
title: Additional file 8 of De novo transcriptome assembly of the cotyledon of Camellia oleifera for discovery of genes regulating seed germination

description: Additional file 8: Table S7. The functional annotation of common expression genes in the Venn diagram.
DOI: 10.6084/m9.figshare.19920996.v1
title: Additional file 5 of De novo transcriptome assembly of the cotyledon of Camellia oleifera for discovery of genes regulating seed germination

description: Additional file 5: Table S4. The functional annotation of in unigenes.
DOI: 10.6084/m9.figshare.19921005
title: Additional file 7 of De novo transcriptome assembly of the cotyledon of Camellia oleifera for discovery of genes regulating seed germination

description: Additional file 7: Table S6. The different genes in each comparison.
DOI: 10.6084/m9.figshare.19921011
title: Additional file 9 of De novo transcriptome assembly of the cotyledon of Camellia oleifera for discovery of genes regulating seed germination

description: Additional file 9: Table S8. The functional annotation of GO and KEGG in all different genes.
DOI: 10.6084/m9.figshare.19921011.v1
title: Additional file 9 of De novo transcriptome assembly of the cotyledon of Camellia oleifera for discovery of genes regulating seed germination

description: Additional file 9: Table S8. The functional annotation of GO and KEGG in all different genes.
DOI: 10.6084/m9.figshare.19921008.v1
title: Additional file 8 of De novo transcriptome assembly of the cotyledon of Camellia oleifera for discovery of genes regulating seed germination

description: Additional file 8: Table S7. The functional annotation of common expression genes in the Venn diagram.
DOI: 10.6084/m9.figshare.19921019
title: Additional file 1 of The effectiveness of the use of telehealth programs in the care of individuals with hypertension and, or diabetes mellitus: systematic review and meta-analysis

description: Additional file 1: “Selected studies for the SR”. It shows all the studies selected for the SR, with their respective titles, authors, year of publication, country of study, type of Telehealth, number of participants in the study, disease addressed and the level of quality of the study. File format: .xls.
DOI: 10.6084/m9.figshare.19921019.v1
title: Additional file 1 of The effectiveness of the use of telehealth programs in the care of individuals with hypertension and, or diabetes mellitus: systematic review and meta-analysis

description: Additional file 1: “Selected studies for the SR”. It shows all the studies selected for the SR, with their respective titles, authors, year of publication, country of study, type of Telehealth, number of participants in the study, disease addressed and the level of quality of the study. File format: .xls.
DOI: 10.6084/m9.figshare.19921042.v1
title: Investigation of the strength of copper and zinc bonds with other constituents of ruminant feedstuffs

description: ABSTRACT The objective of the present study was to evaluate the effect of feed type, pH, and Cu and Zn concentration on Cu and Zn binding with different feedstuffs after in vitro incubation in water. For this purpose, six feedstuffs (wheat straw, grass hay, corn silage, dried distillers grains with solubles, ground corn, and soybean meal) were incubated in ultrapure water (pH≈6.4) with supplemental Cu concentrations equivalent to 0, 5, 10, 15, 20, 30, and 40 mg Cu/kg DM or supplemental Zn concentrations equivalent to 0, 15, 30, 45, 60, 90, and 120 mg Zn/kg DM for 48 h. This experiment was repeated; however, following the 48-h incubation in ultrapure water (pH≈6.4), samples were incubated for one additional hour at a fitted pH of 2.3. Following incubation, the indigestible residue was analyzed for the presence of Cu and Zn. Copper and zinc bind to other dietary constituents at a pH similar to that of the rumen, regardless of the type of feedstuffs (concentrate or roughage). However, in a pH condition similar to that of the abomasum, part of these bonds is broken. In these pH conditions, there is greater breakdown of bonds in concentrate feedstuffs than in roughages, regardless of the mineral analyzed. Comparing these minerals, zinc forms weaker bonds than copper.