cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.57760/sciencedb.j00217.07213
title: Research Progress on the Immune-associated Role of Intratumoral Microbiota in the Occurrence and Development of Lung Cancer
title: 瘤内菌群在肺癌发生发展中的免疫相关研究进展

description: Lung cancer is a malignant tumor with high morbidity and mortality worldwide,and its treatment faces key challenges such as drug resistance and immune escape. Recent studies have found that the intratumoral microbiota play a significant role in the occurrence and development of lung cancer by regulating the immune microenvironment, metabolic reprogramming, and cross-organ interactions with the gut microbiota.Intratumoral pro-tumorigenic microbiota can activate inflammatory pathways such as NF-κB and inhibit T-lymphocyte function, while anti-tumorigenic microbiota enhance anti-tumor immunity through the STING signal and so on.The gut microbiota affect pulmonary immune responses through the "gut-lung axis", and its metabolites such as short-chain fatty acids and secondary bile acids further regulate tumor progression. Targeted microbiota intervention strategies, including engineered bacteria and fecal microbiota transplantation, have shown potential for synergy with immunotherapy in preclinical studies.Despite some progress in this area of research, challenges such as technical difficulties and unclear mechanisms remain.This article reviews the pro-tumorigenic and anti-tumorigenic roles of intratumoral microbiota in the lung cancer microenvironment,and expect to provide new ideas for the early diagnosis and treatment of lung cancer.
description: Lung cancer is a malignant tumor with high morbidity and mortality worldwide,and its treatment faces key challenges such as drug resistance and immune escape. Recent studies have found that the intratumoral microbiota play a significant role in the occurrence and development of lung cancer by regulating the immune microenvironment, metabolic reprogramming, and cross-organ interactions with the gut microbiota.Intratumoral pro-tumorigenic microbiota can activate inflammatory pathways such as NF-κB and inhibit T-lymphocyte function, while anti-tumorigenic microbiota enhance anti-tumor immunity through the STING signal and so on.The gut microbiota affect pulmonary immune responses through the "gut-lung axis", and its metabolites such as short-chain fatty acids and secondary bile acids further regulate tumor progression. Targeted microbiota intervention strategies, including engineered bacteria and fecal microbiota transplantation, have shown potential for synergy with immunotherapy in preclinical studies.Despite some progress in this area of research, challenges such as technical difficulties and unclear mechanisms remain.This article reviews the pro-tumorigenic and anti-tumorigenic roles of intratumoral microbiota in the lung cancer microenvironment,and expect to provide new ideas for the early diagnosis and treatment of lung cancer.
DOI: 10.57760/sciencedb.23694
title: Upwelling metallic ions producing valley region irregularities over low latitude during the 2025 New Year magnetic storm
title: Upwelling metallic ions producing valley region irregularities over low latitude during the 2025 New Year magnetic storm

description: 儋州钙离子激光雷达观测到的2025年1月1日新年磁暴期间的钙离子密度数据，通过激光雷达方程反演获取，钙离子数据的时空分辨率为33s和96m。以及三亚和低纬度多个台站数字测高仪数据，时间分辨率为15min。
description: 儋州钙离子激光雷达观测到的2025年1月1日新年磁暴期间的钙离子密度数据，通过激光雷达方程反演获取，钙离子数据的时空分辨率为33s和96m。以及三亚和低纬度多个台站数字测高仪数据，时间分辨率为15min。
DOI: 10.57760/sciencedb.23683
title: Shifts in functional groups of tree-associated fungi reveal decreasing tree health in German forest ecosystems
title: Shifts in functional groups of tree-associated fungi reveal decreasing tree health in German forest ecosystems

description: Data include the following zip files:Raw Illumina sequencing dataITS.rar (7.9 GB)including forward (R1) and reverse (R2) reads of each sample and replicate of the respective species and marker that have been sequenced. Reads were processed as described in the methods.OTU tablesBeech_ITS_clean.csv (975 KB)Spruce_ITS_clean.csv (1 MB)Trees_ITS.xlsx (5.7 MB)FungiTraits.xlsx (530 KB)including the OTU table of all species for the ITS marker, i.e. Fagus sylvatica and Picea abies. The OTU tables represent the "cleaned dataset" (see methods for details) after merging replicates and removing host DNA as well as any non-target DNA. Only OTUs with at least 177 bp in length and a match of &gt;85% compared to the UNITE database are included. Separate OTU tables for Fagus sylvatica and Picea abies are further provided ("_cleaned"). A table with the respective fungal trait annoation is provided.R Codeincludes the R code for data filtering and data analysis.BuFi_benoit_filter_func_fulltime (37 KB)BuFi_benoit_filter_div_fulltime (115 KB)Supplementary TablesSupplementary tables containing additional information.Table S1: List of all samples including sampling location, year, respective speices, latitude and longitude of sampling locationTable S2: Details of the laboratory workflow
description: Data include the following zip files:Raw Illumina sequencing dataITS.rar (7.9 GB)including forward (R1) and reverse (R2) reads of each sample and replicate of the respective species and marker that have been sequenced. Reads were processed as described in the methods.OTU tablesBeech_ITS_clean.csv (975 KB)Spruce_ITS_clean.csv (1 MB)Trees_ITS.xlsx (5.7 MB)FungiTraits.xlsx (530 KB)including the OTU table of all species for the ITS marker, i.e. Fagus sylvatica and Picea abies. The OTU tables represent the "cleaned dataset" (see methods for details) after merging replicates and removing host DNA as well as any non-target DNA. Only OTUs with at least 177 bp in length and a match of &gt;85% compared to the UNITE database are included. Separate OTU tables for Fagus sylvatica and Picea abies are further provided ("_cleaned"). A table with the respective fungal trait annoation is provided.R Codeincludes the R code for data filtering and data analysis.BuFi_benoit_filter_func_fulltime (37 KB)BuFi_benoit_filter_div_fulltime (115 KB)Supplementary TablesSupplementary tables containing additional information.Table S1: List of all samples including sampling location, year, respective speices, latitude and longitude of sampling locationTable S2: Details of the laboratory workflow
DOI: 10.57760/sciencedb.j00139.00199
title: Genes for Perittopinae phylogeny
title: Genes for Perittopinae phylogeny

description: Perittopinae mitochondrial PCGs, 12SrRNA, 16SrRNA, and nuclear 18S 28SrRNA
description: Perittopinae mitochondrial PCGs, 12SrRNA, 16SrRNA, and nuclear 18S 28SrRNA
DOI: 10.57760/sciencedb.23715
title: Mitochondrial transcription factor A (TFAM) was knocked down in HTR-8/SVneo cells
title: Mitochondrial transcription factor A (TFAM) was knocked down in HTR-8/SVneo cells

description: As shown in the supplementary Figure 1 A, HTR-8/SVneo cells were transfected with negative control siRNA and three different sequences of siTFAM, respectively. Compared with the blank control group, TFAM mRNA levels in the negative control group showed no statistical difference (P = 0.467), but were significantly decreased in siTFAM #1, #2 and #3 (P &lt; 0.001). Furthermore, TFAM protein expression decreased after transfection of siTFAM #1 (B). Moreover, ND-1/β2M and COX-3/β2M in the siTFAM group were significantly lower than those in the negative control group (P = 0.001; P &lt; 0.001), indicating that the mtDNA copy number of trophoblast cells was significantly decreased (C, D). *P&lt; 0.05; **P&lt; 0.01; ***P&lt; 0.001.
description: As shown in the supplementary Figure 1 A, HTR-8/SVneo cells were transfected with negative control siRNA and three different sequences of siTFAM, respectively. Compared with the blank control group, TFAM mRNA levels in the negative control group showed no statistical difference (P = 0.467), but were significantly decreased in siTFAM #1, #2 and #3 (P &lt; 0.001). Furthermore, TFAM protein expression decreased after transfection of siTFAM #1 (B). Moreover, ND-1/β2M and COX-3/β2M in the siTFAM group were significantly lower than those in the negative control group (P = 0.001; P &lt; 0.001), indicating that the mtDNA copy number of trophoblast cells was significantly decreased (C, D). *P&lt; 0.05; **P&lt; 0.01; ***P&lt; 0.001.
DOI: 10.57760/sciencedb.23717
title: Foot acupoint dataset
title: 脚部穴位数据集

description: Dataset of Foot Acupoint Markings
description: Dataset of Foot Acupoint Markings
DOI: 10.57760/sciencedb.23722
title: Local Atom Disorder Mediated Crystal Facet Valence State of PtCu Alloy for Ultrafast Ammonia Oxidation Dehydrogenation
title: Local Atom Disorder Mediated Crystal Facet Valence State of PtCu Alloy for Ultrafast Ammonia Oxidation Dehydrogenation

description: Pt (200) facet of platinum-based alloys exhibit high potential in ammonia oxidation reaction (AOR), but is still a huge bottleneck in activity enhancement due to the sluggish NHx-dehydrogenation kinetics and H-poisoning. Herein, a novelly local-disordered PtCu alloy, with an increasing low-valence-platinum ratio on the (200) facet by H2/Ar post-annealing ambient, was engineered to atomically boost AOR dehydrogenation behaviour through the reconstruction microenvironment of Pt (200) plane. 
description: Pt (200) facet of platinum-based alloys exhibit high potential in ammonia oxidation reaction (AOR), but is still a huge bottleneck in activity enhancement due to the sluggish NHx-dehydrogenation kinetics and H-poisoning. Herein, a novelly local-disordered PtCu alloy, with an increasing low-valence-platinum ratio on the (200) facet by H2/Ar post-annealing ambient, was engineered to atomically boost AOR dehydrogenation behaviour through the reconstruction microenvironment of Pt (200) plane.
DOI: 10.57760/sciencedb.23728
title: R2Net: Enhancement of railway severe weather images based on reinforcement learning
title: R2Net：基于强化学习的铁路恶劣天气图像增强

description: The application of visual tasks such as object detection and semantic segmentation in the field of rail transit is becoming increasingly widespread. However, most existing visual systems are based on image design in clear environments, and the problem of degraded images is inevitable in actual rail transit scenes. For example, trains may encounter harsh weather conditions (such as fog and rain) and low light environments such as tunnels and nighttime during their year-round operation, which significantly reduces the clarity and recognizability of images, directly affecting the performance of advanced visual tasks such as object detection and semantic segmentation. This study focuses on the low visibility problem caused by adverse weather conditions (such as fog and rainfall) and weak light conditions in rail transit scenarios, aiming to improve the quality of degraded images through image enhancement technology and enhance the robustness and reliability of visual systems in complex environments. Through targeted image enhancement methods, research aims to restore the detailed information of degraded images, enhance their recognizability, provide higher quality input data for visual tasks in the field of rail transit, and optimize overall system performance. 
description: The application of visual tasks such as object detection and semantic segmentation in the field of rail transit is becoming increasingly widespread. However, most existing visual systems are based on image design in clear environments, and the problem of degraded images is inevitable in actual rail transit scenes. For example, trains may encounter harsh weather conditions (such as fog and rain) and low light environments such as tunnels and nighttime during their year-round operation, which significantly reduces the clarity and recognizability of images, directly affecting the performance of advanced visual tasks such as object detection and semantic segmentation. This study focuses on the low visibility problem caused by adverse weather conditions (such as fog and rainfall) and weak light conditions in rail transit scenarios, aiming to improve the quality of degraded images through image enhancement technology and enhance the robustness and reliability of visual systems in complex environments. Through targeted image enhancement methods, research aims to restore the detailed information of degraded images, enhance their recognizability, provide higher quality input data for visual tasks in the field of rail transit, and optimize overall system performance.
DOI: 10.57760/sciencedb.23736
title: An arrhythmogenic cardiomyopathy pig model by PKP2 heterozygous knockout
title: An arrhythmogenic cardiomyopathy pig model by PKP2 heterozygous knockout

description: 1.MRI Cine Vedio for PKP2+/- and WT Pigs2.CT for PKP2+/- and WT Pigs
description: 1.MRI Cine Vedio for PKP2+/- and WT Pigs2.CT for PKP2+/- and WT Pigs
DOI: 10.57760/sciencedb.23740
title: Large-scale groundwater system characterization using pressure responses to barometric perturbations caused by the 2022 Hunga Tonga-Hunga Ha’apai volcanic eruption
title: Large-scale groundwater system characterization using pressure responses to barometric perturbations caused by the 2022 Hunga Tonga-Hunga Ha’apai volcanic eruption

description: Large-scale groundwater system characterization using pressure responses to barometric perturbations caused by the 2022 Hunga Tonga-Hunga Ha’apai volcanic eruption
description: Large-scale groundwater system characterization using pressure responses to barometric perturbations caused by the 2022 Hunga Tonga-Hunga Ha’apai volcanic eruption
DOI: 10.57760/sciencedb.j00124.00198
title: Nickel-molybdenum alloy electrodeposited on nickel substrates for optimized hydrogen evolution reaction in acidic electrolytes
title: Nickel-molybdenum alloy electrodeposited on nickel substrates for optimized hydrogen evolution reaction in acidic electrolytes

description: The successful preparation of composite catalysts with coexisting structures of crystalline nickel-molybdenum alloy and molybdenum dioxide on nickel lattice was achieved by employing electrodeposition, annealing and electrochemical activation methods. The catalysts exhibited excellent hydrogen evolution reaction (HER) performance in acidic medium due to the synergistic effect of Ni3Mo alloy and MoO2
description: The successful preparation of composite catalysts with coexisting structures of crystalline nickel-molybdenum alloy and molybdenum dioxide on nickel lattice was achieved by employing electrodeposition, annealing and electrochemical activation methods. The catalysts exhibited excellent hydrogen evolution reaction (HER) performance in acidic medium due to the synergistic effect of Ni3Mo alloy and MoO2
DOI: 10.15468/dl.z8thk2
title: Occurrence Download

description: A dataset containing 217535 species occurrences available in GBIF matching the query:
{
 "DatasetKey" : [
 "is New Zealand Arthropod Collection (NZAC)"
 ]
}

 The dataset includes 217535 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0001287-250426092105405/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.57760/sciencedb.23743
title: Vegetation phenology of geese's summering grounds in MP
title: Vegetation phenology of geese's summering grounds in MP

description: Combining geese tracking data and MODIS NDVI data, we demonstrated synchrony between goose breeding phenology and vegetation growing seasons: gosling hatching coincided with vegetation greening peak (Start of Season, SOS), autumn migration with vegetation yellowing peak (End of Season, EOS). We determined temporal and geographical variation in vegetation SOS, EOS and the Length of Season (LOS = EOS-SOS) as a proxy for gosling development windows across the MP.
description: Combining geese tracking data and MODIS NDVI data, we demonstrated synchrony between goose breeding phenology and vegetation growing seasons: gosling hatching coincided with vegetation greening peak (Start of Season, SOS), autumn migration with vegetation yellowing peak (End of Season, EOS). We determined temporal and geographical variation in vegetation SOS, EOS and the Length of Season (LOS = EOS-SOS) as a proxy for gosling development windows across the MP.
DOI: 10.57760/sciencedb.23744
title: DNMT1 inhibition reprograms T cells to NK-like cells with potent antitumor effects
title: DNMT1 inhibition reprograms T cells to NK-like cells with potent antitumor effects

description: BCL11B ablation reprograms T cells into induced-T-to-NK cells (ITNKs). However, it remains unclear how BCL11B suppresses NK cell programs in T cells. Here, we demonstrate that the maintenance DNA methyltransferase DNMT1 interacts with BCL11B and safeguards the transition from T to NK-like cells. This involves a collective cooperation between DNMT1 and BCL11B that increases BCL11B protein stability and the fidelity of DNA methylation maintenance for NK cell-related genes, while also jointly suppressing NK cell programs in T cells. Moreover, DNMT1 maintains the epigenetic silencing of a distinct subset of NK cell-related genes independent of BCL11B. DNMT1 inhibitor (DNMT1i) or DNMT1 depletion reprograms T cells and chimeric antigen receptor (CAR) T cells into NK-like cells. These NK-like cells exhibit more robust antitumor effects than BCL11B-deficient ITNKs and parental CAR-T cells. Moreover, H3K27me3 synergizes with DNA methylation to repress NK cell-related pathways, and the combination of an EZH2 inhibitor (EZH2i) and DNMT1i potentiate both the reprogramming and cytotoxicity of NK-like cells. Our findings uncover the molecular mechanisms that safeguard T cell identity and provide a rationale for deriving NK-like cell sources with epigenetic inhibitors for cancer immunotherapy.
description: BCL11B ablation reprograms T cells into induced-T-to-NK cells (ITNKs). However, it remains unclear how BCL11B suppresses NK cell programs in T cells. Here, we demonstrate that the maintenance DNA methyltransferase DNMT1 interacts with BCL11B and safeguards the transition from T to NK-like cells. This involves a collective cooperation between DNMT1 and BCL11B that increases BCL11B protein stability and the fidelity of DNA methylation maintenance for NK cell-related genes, while also jointly suppressing NK cell programs in T cells. Moreover, DNMT1 maintains the epigenetic silencing of a distinct subset of NK cell-related genes independent of BCL11B. DNMT1 inhibitor (DNMT1i) or DNMT1 depletion reprograms T cells and chimeric antigen receptor (CAR) T cells into NK-like cells. These NK-like cells exhibit more robust antitumor effects than BCL11B-deficient ITNKs and parental CAR-T cells. Moreover, H3K27me3 synergizes with DNA methylation to repress NK cell-related pathways, and the combination of an EZH2 inhibitor (EZH2i) and DNMT1i potentiate both the reprogramming and cytotoxicity of NK-like cells. Our findings uncover the molecular mechanisms that safeguard T cell identity and provide a rationale for deriving NK-like cell sources with epigenetic inhibitors for cancer immunotherapy.
DOI: 10.57760/sciencedb.23747
title: Mid-infrared supercontinuum based on heterogeneous fiber cascade and inline amplification
title: 基于异质光纤级联和内联放大的中红外超连续谱

description: We propose a mid infrared spectral broadening and broadband amplification technology based on heterogeneous fiber optic systems. Using step index As2S3 fiber, a wide continuous spectrum covering 1.9 to 3.6 μ m was generated at pump energies as low as 0.8 nJ. Coupling erbium-doped fluorozirconate fiber with sulfur based fiber for amplification at around 2.8 μ m, resulting in a frequency band spectrum covering 1.9 to 4.1 μ m. The optical power in the 2.7 to 3 μ m band accounts for 73.2% of the total output power, significantly higher than the proportion in the original continuous spectrum (12.6%). This system provides an all fiber solution for spectral shaping of mid infrared supercontinuum spectra. 
description: We propose a mid infrared spectral broadening and broadband amplification technology based on heterogeneous fiber optic systems. Using step index As2S3 fiber, a wide continuous spectrum covering 1.9 to 3.6 μ m was generated at pump energies as low as 0.8 nJ. Coupling erbium-doped fluorozirconate fiber with sulfur based fiber for amplification at around 2.8 μ m, resulting in a frequency band spectrum covering 1.9 to 4.1 μ m. The optical power in the 2.7 to 3 μ m band accounts for 73.2% of the total output power, significantly higher than the proportion in the original continuous spectrum (12.6%). This system provides an all fiber solution for spectral shaping of mid infrared supercontinuum spectra.
DOI: 10.57760/sciencedb.23751
title: The influence of physical-activity level on negative emotions in college students: the chain-mediated effect of psychological resilience and coping styles
title: The influence of physical-activity level on negative emotions in college students: the chain-mediated effect of psychological resilience and coping styles

description: Purpose: This paper aimed to explore the influence of physical-activity level on college students’ negative emotions and its mediating effect on psychological resilience and coping style.Method: We used a questionnaire on physical-exercise levels that included scales for negative emotions, psychological resilience, and coping style to assess the psychology of 887 college students. Structural-equation modeling and the bootstrap method were used to test and analyze the mediating effect of exercise on psychological resilience and coping style.
description: Purpose: This paper aimed to explore the influence of physical-activity level on college students’ negative emotions and its mediating effect on psychological resilience and coping style.Method: We used a questionnaire on physical-exercise levels that included scales for negative emotions, psychological resilience, and coping style to assess the psychology of 887 college students. Structural-equation modeling and the bootstrap method were used to test and analyze the mediating effect of exercise on psychological resilience and coping style.
DOI: 10.57760/sciencedb.j00139.00201
title: Oryctolagus cuniculus CPA1S282P mutation pancreas Transcriptome
title: Oryctolagus cuniculus CPA1S282P mutation pancreas Transcriptome

description: Oryctolagus cuniculus CPA1S282P mutation pancreas Transcriptome
description: Oryctolagus cuniculus CPA1S282P mutation pancreas Transcriptome
DOI: 10.57760/sciencedb.23755
title: DATA of the study CUB in Mitochondrial Genomes of Three Medicago Species
title: DATA of the study CUB in Mitochondrial Genomes of Three Medicago Species

description: DATA of the study Natural Selection as the Primary Driver of Codon Usage Bias in Mitochondrial Genomes of Three Medicago Species
description: DATA of the study Natural Selection as the Primary Driver of Codon Usage Bias in Mitochondrial Genomes of Three Medicago Species
DOI: 10.15468/dl.nqzvsy
title: Occurrence Download

description: A dataset containing 2677 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Continent is North America",
 "Month is April",
 "OccurrenceStatus is Present",
 "TaxonKey is Zonotrichia leucophrys (J.R.Forster, 1772)",
 "Year 2004-2004"
 ]
}

 The dataset includes 2677 records from 12 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0001280-250426092105405/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.57760/sciencedb.23756
title: WB original data about the article "Astragaloside IV Modulates RNMT to Drive Microglial Phenotypic Shift and Alleviate Cerebral Ischemia-Reperfusion Injury"
title: WB original data about the article "Astragaloside IV Modulates RNMT to Drive Microglial Phenotypic Shift and Alleviate Cerebral Ischemia-Reperfusion Injury"

description: WB original data about the article "Astragaloside IV Modulates RNMT to Drive Microglial Phenotypic Shift and Alleviate Cerebral Ischemia-Reperfusion Injury"
description: WB original data about the article "Astragaloside IV Modulates RNMT to Drive Microglial Phenotypic Shift and Alleviate Cerebral Ischemia-Reperfusion Injury"