cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.5585230.v1
title: Supplementary Material for: Early Nutrition and Growth until the Corrected Age of 2 Years in Extremely Preterm Infants

description: <b><i>Background:</i></b> Extremely preterm birth is associated with a high risk of extrauterine growth retardation, which has been linked with adverse developmental outcomes. <b><i>Objective:</i></b> We investigated whether nutritional management during the first 7 days of life affects growth patterns until the corrected age of 2 years in extremely preterm infants. <b><i>Study Design:</i></b> A retrospective study of 78 extremely preterm (&lt;28 weeks' gestation) neonates was conducted. Data regarding parenteral and enteral intake of energy, protein, lipids, and carbohydrates during the first 7 days of life were collected from patient records. The outcome measures included weight, height, and head circumference with <i>Z</i> scores at term-equivalent age and the corrected ages of 1 and 2 years. Analyses were performed with hierarchical-linear mixed models. <b><i>Results:</i></b> Nutritional intake during the first week of life did not reach the current recommendations. The total energy intake during the first 7 days of life was statistically significantly associated with weight, length, and head circumference until the corrected age of 2 years after adjusting for potential confounding factors. Individual macronutrient intake displayed no association with growth patterns. <b><i>Conclusions:</i></b> Energy intake during the first 7 days of life is associated with growth until the corrected age of 2 years. These results provide support for the aggressive early nutritional management of extremely preterm infants.
DOI: 10.6084/m9.figshare.5584729
title: Supplementary Material for: Increased Bone Morphogenetic Protein Signaling in the Cutaneous Vasculature of Patients with Calciphylaxis

description: <b><i>Background:</i></b> The objective of this study was to investigate the role of bone morphogenetic protein (BMP) signal transduction in the pathogenesis of calciphylaxis. <b><i>Methods:</i></b> Skin biopsy specimens were obtained from 18 patients with, and 12 patients without, calciphylaxis. Tissue sections were stained with antibodies directed against BMP effector proteins phosphorylated-SMAD (p-SMAD) 1/5/9, inhibitor of DNA 1 (Id1), inhibitor of DNA 3 (Id3), and Runx2. The intensity of staining was scored semi-quantitatively as strong versus weak or absent. <b><i>Results:</i></b> Of the 18 patients with calciphylaxis (mean age: 59 ± 8 years), 9 were women and 15 had end-stage renal disease. Of the 12 control patients (mean age: 57 ± 10 years), 8 were women and 8 had end-stage renal disease. Strong staining for p-SMAD 1/5/9 was detected in blood vessels from all calciphylaxis patients. In 1 patient with calciphylaxis, strong staining for p-SMAD 1/5/9 was detected in a blood vessel that did not have evidence of calcification. Id1 and Id3 immunoreactivity was detected in blood vessels from all 12 patients with calciphylaxis that were tested. Runx2 staining was detected in all 6 patients with calciphylaxis who were tested. p-SMAD 1/5/9 immunoreactivity was weak or absent in blood vessels of 10 of the 12 control samples. <b><i>Conclusions:</i></b> The BMP signal transduction pathway is activated in the cutaneous vasculature of calciphylaxis patients. The ability to detect p-SMAD 1/5/9, Id1, and Id3 in cutaneous vasculature may assist in the diagnosis of calciphylaxis. As BMP signaling inhibitors become available, this pathway may serve as a future therapeutic target for calciphylaxis.
DOI: 10.6084/m9.figshare.5584816
title: MLDP-InstanceSet

description: Instance set tested for MLDP PhD research
DOI: 10.6084/m9.figshare.5584729.v1
title: Supplementary Material for: Increased Bone Morphogenetic Protein Signaling in the Cutaneous Vasculature of Patients with Calciphylaxis

description: <b><i>Background:</i></b> The objective of this study was to investigate the role of bone morphogenetic protein (BMP) signal transduction in the pathogenesis of calciphylaxis. <b><i>Methods:</i></b> Skin biopsy specimens were obtained from 18 patients with, and 12 patients without, calciphylaxis. Tissue sections were stained with antibodies directed against BMP effector proteins phosphorylated-SMAD (p-SMAD) 1/5/9, inhibitor of DNA 1 (Id1), inhibitor of DNA 3 (Id3), and Runx2. The intensity of staining was scored semi-quantitatively as strong versus weak or absent. <b><i>Results:</i></b> Of the 18 patients with calciphylaxis (mean age: 59 ± 8 years), 9 were women and 15 had end-stage renal disease. Of the 12 control patients (mean age: 57 ± 10 years), 8 were women and 8 had end-stage renal disease. Strong staining for p-SMAD 1/5/9 was detected in blood vessels from all calciphylaxis patients. In 1 patient with calciphylaxis, strong staining for p-SMAD 1/5/9 was detected in a blood vessel that did not have evidence of calcification. Id1 and Id3 immunoreactivity was detected in blood vessels from all 12 patients with calciphylaxis that were tested. Runx2 staining was detected in all 6 patients with calciphylaxis who were tested. p-SMAD 1/5/9 immunoreactivity was weak or absent in blood vessels of 10 of the 12 control samples. <b><i>Conclusions:</i></b> The BMP signal transduction pathway is activated in the cutaneous vasculature of calciphylaxis patients. The ability to detect p-SMAD 1/5/9, Id1, and Id3 in cutaneous vasculature may assist in the diagnosis of calciphylaxis. As BMP signaling inhibitors become available, this pathway may serve as a future therapeutic target for calciphylaxis.
DOI: 10.6084/m9.figshare.5584816.v1
title: MLDP-InstanceSet

description: Instance set tested for MLDP PhD research
DOI: 10.6084/m9.figshare.5584651
title: Mango's phenological data.xls

description: The Impact of Climate Change on the Reproductive Phenology of Four Local Mango Species (<i>Mangifera</i> spp.) in Makassar, South Sulawesi, Indonesia. This study has been conducted in a forested area of Hasanuddin University campus at Makassar, Indonesia. These data consist of field data collection that were made from June 2013 to December 2014 by observing and recording weekly the production of vegetative shoots, generative shoots, and fruits, as well as the maturity stage of the fruit from the trees of each mango species. The weight and sugar level of the fruits of each species were measured during the fruit ripening season in 2013 and 2014 to assess the impact of seasonal change on fruit quality. Climate data were obtained from two sources: The National Centers for Environmental Prediction (NCEP) and Indonesian Meteorological, Climatological, and Geophysical Agency (BMKG) Region IV Makassar. This study is continued and going on currently
DOI: 10.6084/m9.figshare.5584645
title: Supplementary Material for: Spurious Hyperchloremia in the Presence of Elevated Plasma Salicylate: A Cohort Study

description: <b><i>Background:</i></b> Acute metabolic acidosis is rarely associated with a reduced or negative anion gap (AG), but several case reports have described such an abnormality occurring in the setting of acute salicylate intoxication. The underlying cause of this phenomenon is unclear. <b><i>Methods:</i></b> In this retrospective cohort study, we reviewed our institutional database to identify all patients admitted for salicylate intoxication at Mayo Clinic (Rochester, MN, USA) from January 2010 through December 2012. Serum chloride was measured with the Cobas INTEGRA 400 plus electrode (expedited laboratory test) or Cobas 6000 (routine laboratory test). We compared blood chloride levels measured by the 2 devices in the presence of positive blood salicylate level. <b><i>Results:</i></b> Twelve adult patients with salicylate levels &gt;20 mg/dL had markedly elevated chloride concentrations. The median (interquartile range) chloride level at admission was 120 (107–145) mmol/L on their initial laboratory studies, resulting in reduced or even negative AGs. None of the patients had bromide toxicity, nor did they have any other identifiable cause of hyperchloremia or decreased AG. Further testing of the same blood samples with an alternative measurement system (Roche Cobas 6000) yielded normal chloride values, indicating that falsely elevated chloride values with the initial testing led to the diminished or negative AG values. <b><i>Conclusion:</i></b> Circulating levels of salicylate can interfere with chloride measured by using routine techniques, resulting in spurious hyperchloremia outcomes and erroneous AG values. In patients with acute metabolic acidosis and abnormally reduced or negative AG, salicylate interference with chloride measurement should be suspected.
DOI: 10.6084/m9.figshare.5584666
title: Supplementary Material for: Heritability of End-Stage Renal Disease: A Swedish Adoption Study

description: <b><i>Background/Aims:</i></b> The heritability of end-stage renal disease (ESRD) among adoptees has not been examined so far. By studying adoptees and their biological and adoptive parents, it is possible to differentiate between the genetic causes and environmental causes of familial aggregation. This nationwide study aimed to disentangle the genetic and shared environmental contribution to the familial transmission of ESRD. <b><i>Methods:</i></b> We performed a family study for Swedish-born adoptees (born between 1945 until 1995) and their biological and adoptive parents. The Swedish Multi-Generation Register was linked to the National Patient Registry for the period 1964–2012. ESRD was defined as patients in active uremic care, that is, chronic dialysis or kidney transplantation. OR for ESRD was determined for adoptees with an affected biological parent with ESRD compared with adoptees without a biological parent with ESRD. The OR for ESRD was also calculated in adoptees with an adoptive parent with ESRD compared with adoptees with an adoptive parent without ESRD. Moreover, heritability for ESRD was estimated with Falconer’s regression. <b><i>Results:</i></b> A total of 111 adoptees, 463 adoptive parents, and 397 biological parents were affected by ESRD. The OR for ESRD was 6.41 in adoptees (95% CI 2.96–13.89) of biological parents diagnosed with ESRD. The OR for ESRD was 2.40 in adoptees (95% CI 0.76–7.60) of adoptive parents diagnosed with ESRD. The heritability of ESRD was 59.5 ± 18.2%. <b><i>Conclusion:</i></b> The family history of ESRD in a biological parent is an important risk factor for ESRD. The high heritability indicates that genetic factors play an important role in understanding the etiology of ESRD.
DOI: 10.6084/m9.figshare.5584645.v1
title: Supplementary Material for: Spurious Hyperchloremia in the Presence of Elevated Plasma Salicylate: A Cohort Study

description: <b><i>Background:</i></b> Acute metabolic acidosis is rarely associated with a reduced or negative anion gap (AG), but several case reports have described such an abnormality occurring in the setting of acute salicylate intoxication. The underlying cause of this phenomenon is unclear. <b><i>Methods:</i></b> In this retrospective cohort study, we reviewed our institutional database to identify all patients admitted for salicylate intoxication at Mayo Clinic (Rochester, MN, USA) from January 2010 through December 2012. Serum chloride was measured with the Cobas INTEGRA 400 plus electrode (expedited laboratory test) or Cobas 6000 (routine laboratory test). We compared blood chloride levels measured by the 2 devices in the presence of positive blood salicylate level. <b><i>Results:</i></b> Twelve adult patients with salicylate levels &gt;20 mg/dL had markedly elevated chloride concentrations. The median (interquartile range) chloride level at admission was 120 (107–145) mmol/L on their initial laboratory studies, resulting in reduced or even negative AGs. None of the patients had bromide toxicity, nor did they have any other identifiable cause of hyperchloremia or decreased AG. Further testing of the same blood samples with an alternative measurement system (Roche Cobas 6000) yielded normal chloride values, indicating that falsely elevated chloride values with the initial testing led to the diminished or negative AG values. <b><i>Conclusion:</i></b> Circulating levels of salicylate can interfere with chloride measured by using routine techniques, resulting in spurious hyperchloremia outcomes and erroneous AG values. In patients with acute metabolic acidosis and abnormally reduced or negative AG, salicylate interference with chloride measurement should be suspected.
DOI: 10.6084/m9.figshare.5584666.v1
title: Supplementary Material for: Heritability of End-Stage Renal Disease: A Swedish Adoption Study

description: <b><i>Background/Aims:</i></b> The heritability of end-stage renal disease (ESRD) among adoptees has not been examined so far. By studying adoptees and their biological and adoptive parents, it is possible to differentiate between the genetic causes and environmental causes of familial aggregation. This nationwide study aimed to disentangle the genetic and shared environmental contribution to the familial transmission of ESRD. <b><i>Methods:</i></b> We performed a family study for Swedish-born adoptees (born between 1945 until 1995) and their biological and adoptive parents. The Swedish Multi-Generation Register was linked to the National Patient Registry for the period 1964–2012. ESRD was defined as patients in active uremic care, that is, chronic dialysis or kidney transplantation. OR for ESRD was determined for adoptees with an affected biological parent with ESRD compared with adoptees without a biological parent with ESRD. The OR for ESRD was also calculated in adoptees with an adoptive parent with ESRD compared with adoptees with an adoptive parent without ESRD. Moreover, heritability for ESRD was estimated with Falconer’s regression. <b><i>Results:</i></b> A total of 111 adoptees, 463 adoptive parents, and 397 biological parents were affected by ESRD. The OR for ESRD was 6.41 in adoptees (95% CI 2.96–13.89) of biological parents diagnosed with ESRD. The OR for ESRD was 2.40 in adoptees (95% CI 0.76–7.60) of adoptive parents diagnosed with ESRD. The heritability of ESRD was 59.5 ± 18.2%. <b><i>Conclusion:</i></b> The family history of ESRD in a biological parent is an important risk factor for ESRD. The high heritability indicates that genetic factors play an important role in understanding the etiology of ESRD.
DOI: 10.6084/m9.figshare.5584609
title: Patterns and strategies in scientific collaboration: the perception of researchers - Annex I (complementary tables and figures) [Patrones y estrategias en la colaboración científica: la percepción de los investigadores - Anexo I (tablas y figuras complementarias)].

description: Collaboration is a widespread practice in research activities, whose characteristics and implications are usually analyzed from the co-authorship of scientific publications. A questionnaire was administered to a sample of 3,070 researchers from the universities of the Valencian Region (Spain), in order to deepen the knowledge of this phenomenon, analyzing by branches of knowledge, academic categories and sex, how the contacts between researchers have been established (Pre-collaboration); the development of collaboration as a process (main tasks and motives for collaboration, number of regular collaborators and personal and group factors that make the collaboration successful); the degree of satisfaction with the presentation of collaborative work through scientific publications; and identifying the problems and barriers that hamper it. [La colaboración constituye una práctica generalizada en las actividades de investigación, cuyas características e implicaciones se han analizado generalmente a partir de las coautorías de las publicaciones científicas. Con el objeto de profundizar en el conocimiento de este fenómeno, se ha administrado un cuestionario a una muestra de 3070 investigadores de las universidades de la Comunidad Valenciana (España), analizando por ramas de conocimiento (Artes y Humanidades, Ciencias, Ciencias de la Salud, Ciencias Sociales y Jurídicas e Ingeniería y Arquitectura), categorías académicas y sexo, cómo se establecen los contactos entre los investigadores (pre-colaboración), el desarrollo de la colaboración como proceso (tareas y motivos principales para colaborar, número de colaboradores habituales y factores personales y a nivel de grupos de investigación que hacen que la colaboración resulte exitosa), el grado de satisfacción con la plasmación del trabajo en colaboración a través de las publicaciones científicas e identificando los problemas y barreras que dificultan la colaboración].<br>
DOI: 10.6084/m9.figshare.5584519
title: Deforestation since independence: a quantitative assessment of four decades of land-cover change in Malawi

description: Land cover has changed rapidly across the tropics over the past century; however, detailed historical information describing the extent and possible drivers of such change is widely lacking. Here, we constructed a history of land-cover change at the district level in Malawi over a 37-year period from 1972 to 2009, the immediate post-colonial phase. Overall, there was a loss of 12 760 km2 (36%) of original forested area but also 11 161 km2 of new forest establishment, resulting in a relatively modest overall net loss of 1 599 km2 (5%). We correlated changes in deforestation and forest establishment with changes in socio-economic variables derived from spatially explicit data from the same time period. Deforestation was positively correlated with (in order of influence) changes in male school attendance, sex ratio, population density, hospital bed numbers, protected areas and dependency rate, but negatively correlated with changes in cattle density; forest establishment broadly showed the inverse relationships with the same variables. Although direct drivers of deforestation are well known for Malawi and much of Africa, the significance of socio-economic variables within this study can help to understand the underlying social pressures behind such drivers. In particular, development, population pressure and demographic factors are important predictors of deforestation rate within our study area.
DOI: 10.6084/m9.figshare.5584519.v1
title: Deforestation since independence: a quantitative assessment of four decades of land-cover change in Malawi

description: Land cover has changed rapidly across the tropics over the past century; however, detailed historical information describing the extent and possible drivers of such change is widely lacking. Here, we constructed a history of land-cover change at the district level in Malawi over a 37-year period from 1972 to 2009, the immediate post-colonial phase. Overall, there was a loss of 12 760 km2 (36%) of original forested area but also 11 161 km2 of new forest establishment, resulting in a relatively modest overall net loss of 1 599 km2 (5%). We correlated changes in deforestation and forest establishment with changes in socio-economic variables derived from spatially explicit data from the same time period. Deforestation was positively correlated with (in order of influence) changes in male school attendance, sex ratio, population density, hospital bed numbers, protected areas and dependency rate, but negatively correlated with changes in cattle density; forest establishment broadly showed the inverse relationships with the same variables. Although direct drivers of deforestation are well known for Malawi and much of Africa, the significance of socio-economic variables within this study can help to understand the underlying social pressures behind such drivers. In particular, development, population pressure and demographic factors are important predictors of deforestation rate within our study area.
DOI: 10.6084/m9.figshare.5584492
title: Distributions of times to first division for persister and untreated control cells

description: Distributions of time elapsed to first cell division for persister cells surviving a 3 hours treatment with ampicillin at 25xMIC <br>and then exposed to Lysogeny broth (t&gt;3h). The distributions of time elapsed to first cell division for untreated control cells were measured in separate control experiments where LB only, without ampicillin, was added in the mother machine device at t=0.<br>
DOI: 10.6084/m9.figshare.5584609.v1
title: Patterns and strategies in scientific collaboration: the perception of researchers - Annex I (complementary tables and figures) [Patrones y estrategias en la colaboración científica: la percepción de los investigadores - Anexo I (tablas y figuras complementarias)].

description: Collaboration is a widespread practice in research activities, whose characteristics and implications are usually analyzed from the co-authorship of scientific publications. A questionnaire was administered to a sample of 3,070 researchers from the universities of the Valencian Region (Spain), in order to deepen the knowledge of this phenomenon, analyzing by branches of knowledge, academic categories and sex, how the contacts between researchers have been established (Pre-collaboration); the development of collaboration as a process (main tasks and motives for collaboration, number of regular collaborators and personal and group factors that make the collaboration successful); the degree of satisfaction with the presentation of collaborative work through scientific publications; and identifying the problems and barriers that hamper it. [La colaboración constituye una práctica generalizada en las actividades de investigación, cuyas características e implicaciones se han analizado generalmente a partir de las coautorías de las publicaciones científicas. Con el objeto de profundizar en el conocimiento de este fenómeno, se ha administrado un cuestionario a una muestra de 3070 investigadores de las universidades de la Comunidad Valenciana (España), analizando por ramas de conocimiento (Artes y Humanidades, Ciencias, Ciencias de la Salud, Ciencias Sociales y Jurídicas e Ingeniería y Arquitectura), categorías académicas y sexo, cómo se establecen los contactos entre los investigadores (pre-colaboración), el desarrollo de la colaboración como proceso (tareas y motivos principales para colaborar, número de colaboradores habituales y factores personales y a nivel de grupos de investigación que hacen que la colaboración resulte exitosa), el grado de satisfacción con la plasmación del trabajo en colaboración a través de las publicaciones científicas e identificando los problemas y barreras que dificultan la colaboración].<br>