cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.5545654.v1
title: Origin of Early Cretaceous Guandian adakitic pluton in central eastern China: partial melting of delaminated lower continental crust triggered by ridge subduction

description: Early Cretaceous adakite or adakitic plutons are widely distributed in central eastern China, e.g. lower Yangtze river belt (LYRB), the south Tan–Lu fault (STLF), and the Dabie orogen. Their genesis, however, remains controversial. In this contribution, we present detailed geochemical and geochronological study on the Guandian pluton in central Anhui Province, eastern China, which has been formerly regarded as a part of the north belt in the LYRB and lately classified in the STLF. Namely, it is located near the boundary between ridge subduction related slab melting and partial melting of lower continental crust (LCC). The Guandian pluton consists of quartz monzonite and is metaluminous and high-K calc-alkaline according to the chemical composition. The samples show high SiO<sub>2</sub> (59.15–62.32%), Al<sub>2</sub>O<sub>3</sub> (14.51–15.39%), Sr (892–1184 ppm), Sr/Y (56.74–86.32), and low Y (12.65–18.05 ppm), similar to typical geochemical features of adakite. The Guandian adakitic rocks also exhibit high K<sub>2</sub>O (2.88–3.86%), MgO (3.89–5.24%), and Mg# (55–60), negative anomalies of high field strength elements (e.g. Nb, Ta, and Ti), and positive anomalies of Ba, Pb, and Sr. LA-ICP-MS zircon U–Pb dating yielded a weighted average age of 129.2 ± 0.7 Ma. Calculations of zircon Ce<sup>4+</sup>/Ce<sup>3+</sup> (6.97–145) and (Eu/Eu*)<sub>N</sub> (0.23–0.42) on the basis of <i>in situ</i> zircon trace element analysis indicate that the magma had a lower oxygen fugacity relative to the ore-bearing adakites in the LYRB and Dexing, which is consistent with the fact of ore-barren in the research area. In combination with previous research, we propose that Guandian adakitic pluton was formed by partial melting of delaminated LCC triggered by Early Cretaceous ridge subduction of the Pacific and Izanagi plates. During ridge subduction, physical erosion destructed the thickened LCC and resulted in delamination, while thermal erosion facilitated partial melting of the delaminated LCC.
DOI: 10.6084/m9.figshare.11312750.v1
title: Population Grid for China SSP3RCP6

description: Population Grid for China under SSP3RCP6 from 2010 to 2100
DOI: 10.6084/m9.figshare.12885721
title: Additional file 2 of The fusiform gyrus exhibits an epigenetic signature for Alzheimer’s disease

description: Additional file 2: Table S1. ST1_DEG_of_4_brain_reigons.xls.
DOI: 10.6084/m9.figshare.12885736.v1
title: Additional file 7 of The fusiform gyrus exhibits an epigenetic signature for Alzheimer’s disease

description: Additional file 7: Table S6. ST6_STRING_output_interactions.xlsx.
DOI: 10.6084/m9.figshare.12885811.v1
title: Additional file 4 of Comprehensive analysis of prognostic tumor microenvironment-related genes in osteosarcoma patients

description: Additional file 4.
DOI: 10.6084/m9.figshare.12885715.v1
title: Additional file 10 of The fusiform gyrus exhibits an epigenetic signature for Alzheimer’s disease

description: Additional file 10: Table S9. ST9_Known_AD_risk_factors.txt. All computer codes used in our analyses were deposited in GitHub.
DOI: 10.6084/m9.figshare.12885727
title: Additional file 4 of The fusiform gyrus exhibits an epigenetic signature for Alzheimer’s disease

description: Additional file 4: Table S3. ST3_Venn_common_genes_in_FUS_and_AD-Ns.xlsx.
DOI: 10.6084/m9.figshare.12885739
title: Additional file 8 of The fusiform gyrus exhibits an epigenetic signature for Alzheimer’s disease

description: Additional file 8: Table S7. ST7_validated_genes_function_annotation.xlsx.
DOI: 10.6084/m9.figshare.12885805.v1
title: Additional file 2 of Comprehensive analysis of prognostic tumor microenvironment-related genes in osteosarcoma patients

description: Additional file 2.
DOI: 10.6084/m9.figshare.12885724
title: Additional file 3 of The fusiform gyrus exhibits an epigenetic signature for Alzheimer’s disease

description: Additional file 3: Table S2. ST2_Top_DEG_in_heatmap_AD-risk-factor_TF.xlsx.
DOI: 10.6084/m9.figshare.12885808
title: Additional file 3 of Comprehensive analysis of prognostic tumor microenvironment-related genes in osteosarcoma patients

description: Additional file 3.
DOI: 10.6084/m9.figshare.12885730
title: Additional file 5 of The fusiform gyrus exhibits an epigenetic signature for Alzheimer’s disease

description: Additional file 5: Table S4. ST4_common_up_down_expressed_genes_in_FUS_and_AD-Ns.xlsx.
DOI: 10.6084/m9.figshare.12885805
title: Additional file 2 of Comprehensive analysis of prognostic tumor microenvironment-related genes in osteosarcoma patients

description: Additional file 2.
DOI: 10.6084/m9.figshare.12885730.v1
title: Additional file 5 of The fusiform gyrus exhibits an epigenetic signature for Alzheimer’s disease

description: Additional file 5: Table S4. ST4_common_up_down_expressed_genes_in_FUS_and_AD-Ns.xlsx.
DOI: 10.6084/m9.figshare.12885736
title: Additional file 7 of The fusiform gyrus exhibits an epigenetic signature for Alzheimer’s disease

description: Additional file 7: Table S6. ST6_STRING_output_interactions.xlsx.
DOI: 10.6084/m9.figshare.17079923.v1
title: Improvement of intestinal barrier function, gut microbiota, and metabolic endotoxemia in type 2 diabetes rats by Curcumin

description: Type 2 diabetes mellitus (T2DM) is known as a complex genetic disease characterized by genetic and environmental factors. The imbalanced intestinal flora and intestinal mucosal barrier are considered to be related with T2DM. Curcumin has been proved to affect the progression of T2DM. T2DM Animal was established by Low dose streptozotocin intraperitoneal injection combined with high-fat diet (HFD) feeding. Hematoxylin and Eosin (HE) staining and transfer electron microscopy (TEM) were used to observe morphological changes of intestinal tissues of T2DM rats. Insulin and glucose tolerance tests were performed to investigate the influence of curcumin on blood glucose. Curcumin significantly improved the intestinal integrity, hyperglycemia and insulin resistance in diabetic mice. The metabolic endotoxemia induced by HFD in diabetic rat was inhibited remarkably. Curcumin reversed gut microbiota dysbiosis in diabetic rat caused by HFD. We demonstrated that curcumin could protect intestinal mucosal barrier, improve insulin resistance and reduce blood glucose of diabetic mice. This study might provide experimental evidence for the prevention and treatment in T2DM.
DOI: 10.6084/m9.figshare.12885739.v1
title: Additional file 8 of The fusiform gyrus exhibits an epigenetic signature for Alzheimer’s disease

description: Additional file 8: Table S7. ST7_validated_genes_function_annotation.xlsx.
DOI: 10.6084/m9.figshare.12885742
title: Additional file 9 of The fusiform gyrus exhibits an epigenetic signature for Alzheimer’s disease

description: Additional file 9: Table S8. ST8_Samples_info.xlsx.
DOI: 10.6084/m9.figshare.12885808.v1
title: Additional file 3 of Comprehensive analysis of prognostic tumor microenvironment-related genes in osteosarcoma patients

description: Additional file 3.
DOI: 10.6084/m9.figshare.12885742.v1
title: Additional file 9 of The fusiform gyrus exhibits an epigenetic signature for Alzheimer’s disease

description: Additional file 9: Table S8. ST8_Samples_info.xlsx.
DOI: 10.6084/m9.figshare.12885811
title: Additional file 4 of Comprehensive analysis of prognostic tumor microenvironment-related genes in osteosarcoma patients

description: Additional file 4.
DOI: 10.6084/m9.figshare.12885695
title: Additional file 1 of Genome-wide association study reveals the genetic basis of fiber quality traits in upland cotton (Gossypium hirsutum L.)

description: Additional file 1: Table S1. Analysis of variance (ANOVA) of the cotton fiber quality traits. Table S2. Significant SNPs detected for cotton fiber quality traits by a GWAS. Table S3. Comparisons of the QTLs identified in this study with those identified in previous studies. Table S4. Annotation information of these genes in the QTL regions. Table S5. Primer sequences for RT-qPCR in this study.
DOI: 10.6084/m9.figshare.11314340
title: Retrospective analysis of efficacy, safety, and prognostic factors in a cohort of Chinese hepatocellular carcinoma patients treated with drug-eluting bead transarterial chemoembolization

description: The aim of our study was to assess the efficacy, safety, and prognostic factors of drug-eluting bead transarterial chemoembolization (DEB-TACE) in Chinese hepatocellular carcinoma (HCC) patients. Patients (n=102) diagnosed as primary HCC were consecutively enrolled in this retrospective cohort study. Treatment responses were assessed following the modified Response Evaluation Criteria in Solid Tumors. Progression-free survival (PFS) and overall survival (OS) were evaluated, and adverse events (AEs) as well as liver function-related laboratory indexes of all DEB-TACE records (N=131) were assessed. Complete response (CR) rate, objective response rate, and disease control rate were 51.0, 87.3, and 95.1%, respectively, at 1–3 months post DEB-TACE. The mean PFS and OS were 227 (95%CI: 200–255) days and 343 (95%CI: 309–377) days, respectively. Multivariate logistic regression revealed that portal vein invasion and abnormal total protein (TP) were independent predictive factors for worse CR, and multivariate Cox's regression analysis showed that multifocal disease independently correlated with shorter PFS. Most of the liver function-related laboratory indexes worsened at 1 week but recovered at 1–3 months post-treatment, only the percentage of patients with abnormal ALP increased at 1–3 months. In addition, 112 (85.5%), 84 (64.1%), 53 (40.5%), 40 (30.5%), and 16 (12.2%) patients had pain, fever, nausea, vomiting, and other AEs, respectively. DEB-TACE is efficient and safe in Chinese HCC patients, and portal vein invasion, abnormal TP level as well as multifocal disease could be used as unfavorable prognostic factors to DEB-TACE treatment.
DOI: 10.6084/m9.figshare.12885715
title: Additional file 10 of The fusiform gyrus exhibits an epigenetic signature for Alzheimer’s disease

description: Additional file 10: Table S9. ST9_Known_AD_risk_factors.txt. All computer codes used in our analyses were deposited in GitHub.
DOI: 10.6084/m9.figshare.11314340.v1
title: Retrospective analysis of efficacy, safety, and prognostic factors in a cohort of Chinese hepatocellular carcinoma patients treated with drug-eluting bead transarterial chemoembolization

description: The aim of our study was to assess the efficacy, safety, and prognostic factors of drug-eluting bead transarterial chemoembolization (DEB-TACE) in Chinese hepatocellular carcinoma (HCC) patients. Patients (n=102) diagnosed as primary HCC were consecutively enrolled in this retrospective cohort study. Treatment responses were assessed following the modified Response Evaluation Criteria in Solid Tumors. Progression-free survival (PFS) and overall survival (OS) were evaluated, and adverse events (AEs) as well as liver function-related laboratory indexes of all DEB-TACE records (N=131) were assessed. Complete response (CR) rate, objective response rate, and disease control rate were 51.0, 87.3, and 95.1%, respectively, at 1–3 months post DEB-TACE. The mean PFS and OS were 227 (95%CI: 200–255) days and 343 (95%CI: 309–377) days, respectively. Multivariate logistic regression revealed that portal vein invasion and abnormal total protein (TP) were independent predictive factors for worse CR, and multivariate Cox's regression analysis showed that multifocal disease independently correlated with shorter PFS. Most of the liver function-related laboratory indexes worsened at 1 week but recovered at 1–3 months post-treatment, only the percentage of patients with abnormal ALP increased at 1–3 months. In addition, 112 (85.5%), 84 (64.1%), 53 (40.5%), 40 (30.5%), and 16 (12.2%) patients had pain, fever, nausea, vomiting, and other AEs, respectively. DEB-TACE is efficient and safe in Chinese HCC patients, and portal vein invasion, abnormal TP level as well as multifocal disease could be used as unfavorable prognostic factors to DEB-TACE treatment.
DOI: 10.6084/m9.figshare.12887222
title: County-level CO2 sequestration in China

description: A dataset of county-level CO2 sequestration in China.
DOI: 10.6084/m9.figshare.11314370
title: Outcomes of Chronic Total Occlusions in Coronary Arteries According to Three Therapeutic Strategies: A Meta-analysis with 6985 Patients from 8 Published Observational Studies

description: Abstract Objective: To perform a systematic review and meta-analysis of studies comparing coronary artery bypass grafting (CABG), percutaneous coronary intervention (PCI), and medical treatment (MT) in patients with chronic total occlusions (CTOs). Methods: We identified eligible observational studies published in the China National Knowledge Infrastructure database, PubMed, Excerpta Medica database, Google Scholar, Cochrane Library, Web of Science, and "Clinical trials" registration from 1999 to October 2018. Main outcome measures were all-cause mortality, cardiac death, major adverse cardiac events (MACEs), and myocardial infarction (MI). Results: There were eight observational studies including 6985 patients. Patients' mean age was 64.4 years. Mean follow-up time was 4.3 years. Comparing with MT (2958 patients), PCI (3157 patients) presented decreased all-cause mortality (odd ratio [OR]: 0.46, 95% confidence interval [CI]: 0.36-0.60; P&lt;0.001), cardiac death (OR: 0.40, 95% CI: 0.31-0.52; P&lt;0.001), MACE (OR: 0.55, 95% CI: 0.43-0.71; P&lt;0.001), and MI (OR: 0.40, 95% CI: 0.26-0.62; P&lt;0.001). Comparing with MT, CABG (613 patients) presented lower all-cause mortality (OR: 0.50, 95% CI: 0.36-0.69; P&lt;0.001) and MACE (OR: 0.50, 95% CI: 0.26-0.96; P=0.04), but not lower MI (OR: 0.23, 95% CI: 0.03-1.54; P=0.13) and cardiac death (OR: 0.83, 95% CI: 0.51-1.35). Comparing with CABG, PCI did not present decreased risk for those outcomes. Conclusions: PCI or CABG was associated with better clinical outcome in patients with CTO than MT. PCI is not better than CABG in decreasing mortality, MI, cardiac death, and MACE in coronary CTO patients.
DOI: 10.6084/m9.figshare.11314370.v1
title: Outcomes of Chronic Total Occlusions in Coronary Arteries According to Three Therapeutic Strategies: A Meta-analysis with 6985 Patients from 8 Published Observational Studies

description: Abstract Objective: To perform a systematic review and meta-analysis of studies comparing coronary artery bypass grafting (CABG), percutaneous coronary intervention (PCI), and medical treatment (MT) in patients with chronic total occlusions (CTOs). Methods: We identified eligible observational studies published in the China National Knowledge Infrastructure database, PubMed, Excerpta Medica database, Google Scholar, Cochrane Library, Web of Science, and "Clinical trials" registration from 1999 to October 2018. Main outcome measures were all-cause mortality, cardiac death, major adverse cardiac events (MACEs), and myocardial infarction (MI). Results: There were eight observational studies including 6985 patients. Patients' mean age was 64.4 years. Mean follow-up time was 4.3 years. Comparing with MT (2958 patients), PCI (3157 patients) presented decreased all-cause mortality (odd ratio [OR]: 0.46, 95% confidence interval [CI]: 0.36-0.60; P&lt;0.001), cardiac death (OR: 0.40, 95% CI: 0.31-0.52; P&lt;0.001), MACE (OR: 0.55, 95% CI: 0.43-0.71; P&lt;0.001), and MI (OR: 0.40, 95% CI: 0.26-0.62; P&lt;0.001). Comparing with MT, CABG (613 patients) presented lower all-cause mortality (OR: 0.50, 95% CI: 0.36-0.69; P&lt;0.001) and MACE (OR: 0.50, 95% CI: 0.26-0.96; P=0.04), but not lower MI (OR: 0.23, 95% CI: 0.03-1.54; P=0.13) and cardiac death (OR: 0.83, 95% CI: 0.51-1.35). Comparing with CABG, PCI did not present decreased risk for those outcomes. Conclusions: PCI or CABG was associated with better clinical outcome in patients with CTO than MT. PCI is not better than CABG in decreasing mortality, MI, cardiac death, and MACE in coronary CTO patients.
DOI: 10.6084/m9.figshare.7643126
title: Table S2 from Distinct effects of short-term reconstructed topsoil on soya bean and corn rhizosphere bacterial abundance and communities in Chinese Mollisol

description: The correlations between soil biogeochemical characteristics and significantly affected genus by topsoil depths
DOI: 10.6084/m9.figshare.7643126.v1
title: Table S2 from Distinct effects of short-term reconstructed topsoil on soya bean and corn rhizosphere bacterial abundance and communities in Chinese Mollisol

description: The correlations between soil biogeochemical characteristics and significantly affected genus by topsoil depths
DOI: 10.6084/m9.figshare.7643129
title: Table S1 from Distinct effects of short-term reconstructed topsoil on soya bean and corn rhizosphere bacterial abundance and communities in Chinese Mollisol

description: The correlation of OTU numbers, a-diversity, bacterial abundance and soil respiration with soil properties
DOI: 10.6084/m9.figshare.7643129.v1
title: Table S1 from Distinct effects of short-term reconstructed topsoil on soya bean and corn rhizosphere bacterial abundance and communities in Chinese Mollisol

description: The correlation of OTU numbers, a-diversity, bacterial abundance and soil respiration with soil properties
DOI: 10.6084/m9.figshare.20224834
title: Additional file 2 of Efficacy and safety of a 3D-printed arthrodesis prosthesis for reconstruction after resection of the proximal humerus: preliminary outcomes with a minimum 2-year follow-up

description: Additional file 2: Supplemental file 2. Raw data of the eleven patients who underwent replacement of a 3D-printed arthrodesis prosthesis after resection of the proximal humerus.
DOI: 10.25442/hku.25201871
title: <b>Additional materials for the journal article titled "Survey of anatomical organization of archosaurian skulls reveals major evolutionary and ontogenetic transformations in modern birds."</b>

description: The skull is a hallmark of Vertebrata clade critical both for their phylogenetic success and taxonomic nomenclature. The evolution of vertebrate skull morphology is characterized by changes in skull shape and topology. Cranial skeleton topology traits tend to be less understood and include the number cranial bones and their relative arrangement, believed to be important for biomechanical and other functions. Rearrangement and co-option of pre-existing bones occur as the skeletal morphology of tetrapods evolves to produce new functions or structures. During development, evolutionary rearrangement of a given bone is limited by heterochrony and the development of neighbouring bones. Cranial rearrangement was previously explored in archosaurs using Anatomical Network Analysis (AnNA) but unable to reconstruct their vast diversity, nor pinpoint these rearrangements in time. To address this, we compiled the most comprehensive dataset to date, including 109 species of non-archosaurian archosauriformes, pseudosuchians, Paleogene birds, and modern birds. To identify the ontogenetic stage during which topological disparity is initiated, we used juvenile theropods, and for the first time, late-stage embryos, juvenile, and subadult pseudosuchians, and constructed the topological morphospace using AnNA. Specialization via fusion of cranial bones in archosaurs could be traced from crown archosaurs with subtle changes throughout the Mesozoic, when pseudosuchians and avemetatarsalians overlapped with non-archosaurian archosauriforms in the morphospace. The morphospace subsequently expanded with the rise of Aves, which were remarkably distinct from their predecessors. Interestingly, juvenile birds from different orders were not significantly different from each other, or non-avian dinosaurs, whereas their adult stages demonstrated remarkable differences. In contrast, extant crocodylians were different from non-crocodylian pseudosuchians since young. Ancestral state reconstruction analysis by maximum-likelihood showed the last common ancestor of Aves and Ichthyornis had an intermediately fused skull and kinetic closest to waterfowls (Anseriforms). Observations from bird skulls suggested that functional limitations from cranial arrangement may be compensated by morphological modification to adapt to similar environmental stimuli. When trends on skull shape and topological changes are combined, it becomes evident that these two dimensions of archosaur skull morphology are largely independent and are both needed to explain the observed diversity.
DOI: 10.25442/hku.25201871.v1
title: <b>Additional materials for the journal article titled "Survey of anatomical organization of archosaurian skulls reveals major evolutionary and ontogenetic transformations in modern birds."</b>

description: The skull is a hallmark of Vertebrata clade critical both for their phylogenetic success and taxonomic nomenclature. The evolution of vertebrate skull morphology is characterized by changes in skull shape and topology. Cranial skeleton topology traits tend to be less understood and include the number cranial bones and their relative arrangement, believed to be important for biomechanical and other functions. Rearrangement and co-option of pre-existing bones occur as the skeletal morphology of tetrapods evolves to produce new functions or structures. During development, evolutionary rearrangement of a given bone is limited by heterochrony and the development of neighbouring bones. Cranial rearrangement was previously explored in archosaurs using Anatomical Network Analysis (AnNA) but unable to reconstruct their vast diversity, nor pinpoint these rearrangements in time. To address this, we compiled the most comprehensive dataset to date, including 109 species of non-archosaurian archosauriformes, pseudosuchians, Paleogene birds, and modern birds. To identify the ontogenetic stage during which topological disparity is initiated, we used juvenile theropods, and for the first time, late-stage embryos, juvenile, and subadult pseudosuchians, and constructed the topological morphospace using AnNA. Specialization via fusion of cranial bones in archosaurs could be traced from crown archosaurs with subtle changes throughout the Mesozoic, when pseudosuchians and avemetatarsalians overlapped with non-archosaurian archosauriforms in the morphospace. The morphospace subsequently expanded with the rise of Aves, which were remarkably distinct from their predecessors. Interestingly, juvenile birds from different orders were not significantly different from each other, or non-avian dinosaurs, whereas their adult stages demonstrated remarkable differences. In contrast, extant crocodylians were different from non-crocodylian pseudosuchians since young. Ancestral state reconstruction analysis by maximum-likelihood showed the last common ancestor of Aves and Ichthyornis had an intermediately fused skull and kinetic closest to waterfowls (Anseriforms). Observations from bird skulls suggested that functional limitations from cranial arrangement may be compensated by morphological modification to adapt to similar environmental stimuli. When trends on skull shape and topological changes are combined, it becomes evident that these two dimensions of archosaur skull morphology are largely independent and are both needed to explain the observed diversity.
DOI: 10.6084/m9.figshare.9740654
title: Additional file 7: of Intrarenal microRNA signature related to the fibrosis process in chronic kidney disease: identification and functional validation of key miRNAs

description: Results for GO annotation and KEGG pathway enrichment analysis for predicted target genes of miR-4709-3p. (XLSX 111 kb)
DOI: 10.6084/m9.figshare.12886058.v1
title: Additional file 1 of DLBCL with amplification of JAK2/PD-L2 exhibits PMBCL-like CNA pattern and worse clinical outcome resembling those with MYD88 L265P mutation

description: Additional file 1. MLPA results and clinical follow-up data. The clinicopathological characteristics, clinical follow-up data and MLPA results are showed in this file.