DOI: 10.7270/q2n018jc
title: BindingDB Entry 50048224: Structure guided design of a series of selective pyrrolopyrimidinone MARK inhibitors.

description: Small molecule binding data for protein 5'-AMP-activated protein kinase Complex 1, AKT/p21CIP1, AMPK alpha2/beta1/gamma1, Activin receptor type-1B, Aurora kinase A/B, Axin-1/Glycogen synthase kinase-3 beta, BR serine/threonine-protein kinase 2, CDK-activating kinase assembly factor MAT1/Cyclin H/Cyclin-dependent kinase 7, CaM kinase IV, Casein kinase I/MDM2, Casein kinase II alpha/beta, Cyclin-Dependent Kinase 5 (CDK5), Cyclin-Dependent Kinase 9 (CDK9), Cyclin-dependent kinase 2, Death-associated protein kinase 1, Dual specificity mitogen-activated protein kinase kinase 1, Dual specificity mitogen-activated protein kinase kinase 6, Dual specificity protein kinase CLK2, Dual-specificity tyrosine-phosphorylation regulated kinase 1A, Ephrin receptor, Ephrin type-A receptor 3 (EPHA3), Epidermal growth factor receptor, Epidermal growth factor receptor and ErbB2 (HER1 and HER2), Fibroblast growth factor receptor 2, G protein-coupled receptor kinase 4, G protein-coupled receptor kinase 6, G-protein coupled receptor kinase 2, Glycogen synthase kinase-3, Hepatocyte growth factor receptor, IKK epsilon/TBK1, Inhibitor of NF-kappa-B kinase (IKK), Insulin receptor, Insulin-like growth factor I receptor, Interleukin-1 receptor-associated kinase 1, Interleukin-1 receptor-associated kinase 4, JAK2/JAK1, JAK2/TYK2, JAK3/JAK1, Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2), Lysyl-tRNA synthetase, MAP kinase ERK2, MAP kinase-activated protein kinase 2, MAP kinase-activated protein kinase 5, MAP/microtubule affinity-regulating kinase 4, Macrophage colony stimulating factor receptor, Mitogen-activated protein kinase 13 (MAPK13), Mitogen-activated protein kinase 14, Mitogen-activated protein kinase 9, Mitogen-activated protein kinase kinase kinase 8, NT-3 growth factor receptor, NUAK family SNF1-like kinase 1, Neurotrophic tyrosine kinase receptor, PAK1, PAS domain-containing serine/threonine-protein kinase, Phosphoinositide 3-Kinase (PI3K), delta, Protein kinase C (PKC), Protein kinase C iota (PKCι), Protein kinase C theta type, Protein kinase N1, Pyruvate dehydrogenase kinase isoenzyme 1 (PDK1), RAF serine/threonine protein kinase, Rho-associated protein kinase, Ribosomal protein S6 kinase (P70S6K), Ribosomal protein S6 kinase alpha 3, SRC, Serine/threonine-protein kinase AKT, Serine/threonine-protein kinase Chk1, Serine/threonine-protein kinase Chk2, Serine/threonine-protein kinase MRCK-A, Serine/threonine-protein kinase MST4, Serine/threonine-protein kinase NEK6, Serine/threonine-protein kinase Nek2, Serine/threonine-protein kinase Nek4, Serine/threonine-protein kinase PIM, Serine/threonine-protein kinase PLK1, Serine/threonine-protein kinase SRPK1, Serine/threonine-protein kinase Sgk1, Serine/threonine-protein kinase TAO2, Serine/threonine-protein kinase c-TAK1, Sphingosine kinase 1 (SPHK1), Testis-specific serine/threonine-protein kinase 1, Tyrosine-protein kinase ABL1, Tyrosine-protein kinase BMX, Tyrosine-protein kinase BRK, Tyrosine-protein kinase BTK, Tyrosine-protein kinase ITK/TSK, Tyrosine-protein kinase JAK1, Tyrosine-protein kinase Kit (Kit), Tyrosine-protein kinase ZAP-70, Tyrosine-protein kinase receptor FLT3, VEGF-receptor 2 and tyrosine-protein kinase SRC, Vascular endothelial growth factor receptor 2, Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2), Voltage-gated potassium channel subunit Kv7.1/Misshapen-like kinase 1, c-Jun N-terminal kinase, JNK, and cAMP-dependent protein kinase (PKA), Uniprot O00141, O00329, O14757, O14920, O15264, O60285, O60563, O60674, O75116, O96017, P00519, P00533, P04626, P04629, P06213, P06239, P07333, P08069, P08581, P08631, P10721, P11309, P12931, P15056, P17612, P21802, P23443, P23458, P24941, P25098, P27448, P27986, P28482, P29320, P29322, P29323, P29597, P31749, P31751, P32298, P35968, P36888, P36896, P41279, P41743, P43250, P43403, P45983, P45984, P48729, P49137, P49760, P49840, P49841, P50613, P50750, P51617, P51812, P51813, P51946, P51948, P51955, P51957, P52333, P52564, P53350, P53355, P54619, P54646, P68400, Q00535, Q02750, Q02763, Q04759, Q05513, Q06187, Q08881, Q13131, Q13153, Q13464, Q13627, Q13882, Q14164, Q15046, Q15078, Q15118, Q16288, Q16512, Q16539, Q16566, Q5S007, Q5VT25, Q8IW41, Q8IWQ3, Q8N4C8, Q96GD4, Q96L34, Q96RG2, Q96SB4, Q9BXA7, Q9HC98, Q9NWZ3, Q9NYA1, Q9P289, Q9UHD2, Q9UL54, Q9Y243, and Q9Y478