cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.11267522.v1
title: Ocular surface changes in the treatment of rosacea: comparison between low-dose oral isotretinoin and doxycycline

description: ABSTRACT Purpose: To compare the impact of ocular changes between systemic treatment with doxycycline and low-dose oral isotretinoin in patients with moderate-to-severe papulopustular rosacea. Methods: Patients were randomized to receive either isotretinoin 0.3-0.4 mg/kg (group A) or doxycycline 100 mg/day (group B) for 16 weeks. Ocular symptoms were searched and evaluated, including best-corrected visual acuity (BCVA), Schirmer test, breakup time, rose bengal staining score, and meibomian gland dysfunction grading. The patients were retested at the end of treatment. Results: The present study included 39 patients (30 females and 9 males). Best-corrected visual acuity was &gt; 20/30 in &gt;90% of patients in both groups and did not change after treatment. After treatment, improvement in ocular symptoms and meibomian gland dysfunction was more pronounced in group B (p&lt;0.05); the other parameters did not reach statistical significance. Conclusion: Doxycycline improved meibomian gland dysfunction, ocular symptoms, and ocular surface in patients with rosacea. Even though some patients experienced worsening meibomian gland dysfunction and symptoms, no subject experienced any serious complications after administration of low-dose isotretinoin.
DOI: 10.6084/m9.figshare.11267489
title: Drying kinetics and thermodynamic properties of patawa pulp (Oenocarpus bataua Mart.)

description: Abstract The patawa is an Amazonian fruit that, due to its sensory and nutritional properties, has aroused the interest of the scientific community. However, its high moisture content confers high perishability to the fresh product. Thus the convective drying kinetics were studied and the thermodynamic properties of the patawa pulp determined. Drying was carried out at different temperatures (40, 50 and 60 °C) and layer thicknesses (0.3 and 0.6 cm), with a constant air velocity of 1.8 m s-1. Different thin layer drying models were adjusted to the experimental data. Increasing the air temperature and decreasing the layer thickness increased the moisture removal rate and thus reduced the overall process time. Based on the statistical parameters, the Midilli model was the one that best described the drying kinetics of the samples under all conditions evaluated. The effective diffusion coefficients increased with increase in air temperature, showing magnitudes to the order of 10-10 m2 s-1, and its temperature dependence was represented by the Arrhenius equation, with the activation energy (Ea) from 32.41 and 40.10 kJ mol-1 for the thicknesses of 0.6 and 0.3 cm, respectively. The variations in enthalpy (ΔH) and entropy (ΔS) decreased with increasing drying temperature, being lowest in the sample dehydrated in a 0.6 cm layer, while the variation in Gibbs free energy (ΔG) increased with the increase in temperature, being higher when dried in a 0.3 cm layer.
DOI: 10.6084/m9.figshare.11267495
title: Effects of Laser Remelting Process on Microstructure and Wear Behavior of WC Coating Sprayed by HVOF

description: ABSTRACT The wear of industrial and agricultural components and equipment represents a major factor of depreciation of capital and source of expenses with maintenance and replacement of mechanical components. As the wear is an essentially superficial phenomenon, involving the undesirable mechanical removal of surface materials, the solution studied in this work was to analyze the abrasive wear behavior of a surface coated with Tungsten Carbide (WC) sprayed by the thermal spray method by High Velocity Oxygen Fuel - HVOF on a SAE 1020 steel substrate. To improve the adhesion between the coating and substrate, to reduce the porosity present in the coating and to obtain better results in the abrasive wear test, a CO2 laser treatment with a power of 125 W was applied to the surface of the WC coating. The samples coated by HVOF and HVOF + CO2 laser treatment were characterized by Scanning Electron Microscopy (SEM) to evaluate the morphology and microstructure of the coating and interface, microhardness analysis, wear and roughness test were done. It was obtained as a result that the sample coated by the HVOF method showed a better performance in tests of microhardness, wear and roughness compared to the sample treated with the laser.
DOI: 10.6084/m9.figshare.11267504.v1
title: Amassing of Hydroxymethylfurfural, 2- Furfural and 5- Methyl furfural in orange (Citrus reticulata) juice during storage

description: Abstract Vitamin C is imperative component of our nutrition and used as additive in many foods owing to its high antioxidant activity. The degradation of vitamin C content in orange juice during storage was evaluated in this study. Degradation of vitamin C in orange juice during 40 days storage at 0, 05, 15, 25, and 40 °C was analyzed and evaluated. Hydroxymethylfurfural (HMF) accumulation in orange juice acts as an indicator of ascorbic acid degradation. The initial vitamin C content in orange juice was 34.26 mg/100 mL that reduced when subjected to various storage conditions such as temperature and time. The loss of vitamin C during storage was lowest at 0 °C and the losses increased with rise in temperature. The Vitamin C content after 40 days in orange juice at 0 °C were 7.19 mg/100 mL while the Vitamin C content reduced to 1.89 mg/100 mL in orange juice that were kept at 40 °C. Hence, with increase in temperature, the Vitamin C was degraded and accretion of HMF, 5 methyl furfural, and 2 methyl furfural was increased. The zero-order interaction between storage time and treatment showed significant influence on HMF.
DOI: 10.6084/m9.figshare.11267486
title: Influence of the addition of KCl and CaCl2 blends on the physicochemical parameters of salted meat products throughout the processing steps

description: Abstract The objective of this study was to evaluate the effects of different chloride salts (NaCl, KCl, and CaCl2) on the characteristics of salted meat products through the determination of moisture, pH, aw, chloride, ash levels, cooking loss, and instrumental color during the processing steps. Four salted meat treatments were elaborate using the following salts in the wet and dry salting steps: FC1: 100% NaCl; F1: 50% NaCl + 50% KCl; F2: 50% NaCl + 25% CaCl2; F3: 50% NaCl + 25% KCl + 25% CaCl2. The addition of CaCl2 led to the lowest pH and changes in aw, moisture, ash levels, and instrumental color when compared to the other treatments, which was different from the control (100% NaCl) and F1 (50% NaCl + 50% KCl), thus evidencing the great effect of CaCl2 on the characteristics of salted meat products during the whole processing. The partial replacement of NaCl by KCl and/or CaCl2 greatly increased the cooking loss of salted meat products. The replacement of NaCl by KCl promoted similar quality parameters.
DOI: 10.6084/m9.figshare.11267510.v1
title: Safety assessment of Spirulina platensis through sprague dawley rats modeling

description: Abstract Health safety of spirulina (Spirulina platensis) for food application was evaluated through hematology and histopathology of liver, spleen and kidney in Sprague Dawley rats fed on three isoproteic diets maintained to 10% protein for forty five days. Three groups of rats were maintained as control diet casein (R-C); diet containing crude spirulina (R-S) and diet containing purified spirulina protein (R-SPI). Hematological profile of the rats group fed on spirulina diets showed no significant increase in white blood cells (WBCs), while there was decreasing trend in the levels of neutrophils (60.46 ± 2.60%) and lymphocytes (33.53 ± 1.06%) in rats that were fed on spirulina diet (R-S) than the other tested experimental diet group. Histopathological examination revealed normal architecture of the liver with no abnormality in kidneys and spleen exhibiting safety of spirulina in both forms to mitigate protein energy malnutrition widely prevalent in developing countries.
DOI: 10.6084/m9.figshare.11267483
title: Intra- and interobserver reliability of a modified distraction test based on digital images to assess lower eyelid horizontal tension

description: ABSTRACT Purpose: Inferior eyelid laxity is classically evaluated using “snap-back” and “distraction” tests. This study aimed to assess the reproducibility of the technique used to indirectly quantify the horizontal tension in the lower eyelids using digital image processing. Methods: This longitudinal study was conducted to assess the reproducibility of a new technique that quantifies the horizontal tension in the lower eyelid. The study was conducted at the Hospital das Clínicas of Porto Alegre. The protocol was established by two trained ophthalmologist examiners, allowing intra- and interobserver agreement analyses. Image acquisition was done in two stages: the first image was captured with the eyelid in primary gaze position and the second with the eyelid in traction position. All images and measurements were processed using Image J 1.33m software from the National Institute of Health. The Bland-Altman method, intraclass correlation coefficients, concordance correlation coefficients, and technical measurement error were used to evaluate reproducibility. Results: The study participants comprised healthy individuals with no ophthalmologic pathologies. The measurements obtained in the neutral position showed a slightly higher agreement than those obtained in the traction position. The mean difference between the measurements performed in the traction position was 0.028 ± 0.7 mm and 0.014 ± 0.9 mm in the intra- and interobserver analyses, respectively. The Bland-Altman method demonstrated adequate confidence limits for both measurements. Correlation coefficients for measurements varied between 0.87 [95% confidence interval (CI) 0.68-0.95] and 0.91 (95% CI 0.77-0.97) in the neutral position and between 0.72 (95% CI 0.37-0.89) and 0.76 (95% CI 0.4-0.91) in the traction position. Conclusion: A high intra- and interobserver concordance was observed in the studied method to quantify lower eyelid tension. The proposed method is simple and easily reproducible, and to the best our knowledge, this is the first method that quantifies lower eyelid horizontal tension on the basis of digital image processing. This modified distraction test might be useful in studies quantifying lower eyelid horizontal tension.
DOI: 10.6084/m9.figshare.11267489.v1
title: Drying kinetics and thermodynamic properties of patawa pulp (Oenocarpus bataua Mart.)

description: Abstract The patawa is an Amazonian fruit that, due to its sensory and nutritional properties, has aroused the interest of the scientific community. However, its high moisture content confers high perishability to the fresh product. Thus the convective drying kinetics were studied and the thermodynamic properties of the patawa pulp determined. Drying was carried out at different temperatures (40, 50 and 60 °C) and layer thicknesses (0.3 and 0.6 cm), with a constant air velocity of 1.8 m s-1. Different thin layer drying models were adjusted to the experimental data. Increasing the air temperature and decreasing the layer thickness increased the moisture removal rate and thus reduced the overall process time. Based on the statistical parameters, the Midilli model was the one that best described the drying kinetics of the samples under all conditions evaluated. The effective diffusion coefficients increased with increase in air temperature, showing magnitudes to the order of 10-10 m2 s-1, and its temperature dependence was represented by the Arrhenius equation, with the activation energy (Ea) from 32.41 and 40.10 kJ mol-1 for the thicknesses of 0.6 and 0.3 cm, respectively. The variations in enthalpy (ΔH) and entropy (ΔS) decreased with increasing drying temperature, being lowest in the sample dehydrated in a 0.6 cm layer, while the variation in Gibbs free energy (ΔG) increased with the increase in temperature, being higher when dried in a 0.3 cm layer.
DOI: 10.6084/m9.figshare.11267480
title: Numerical implementation of a micromechanics-based viscoelastic model for geomaterials with isotropically distributed micro-fractures

description: Abstract The constitutive behavior of geomaterials is generally affected by the presence at different scales of discontinuity surfaces with different sizes and orientations. According to their mechanical behavior, such discontinuities can be distinguished as cracks or fractures. Fractures are interfaces that can transfer normal and tangential stresses, whereas cracks are discontinuities without stress transfer. Regarding the formulation of the behavior of materials with isotropic distribution of micro-cracks or fractures, previous works had essentially focused on their instantaneous response induced by structural loading. Few research works have addressed time-dependent (delayed) behavior of such materials. The present contribution describes the formulation and computational implementation of a micromechanics-based modeling for viscoelastic media with an isotropic distribution of micro-fractures. The homogenized viscoelastic properties are assessed by implementing a reasoning based on linear homogenization schemes (Mori-Tanaka) together with the correspondence principle for non-aging viscoelastic materials. It is shown that the homogenized viscoelastic behavior can be described by means of a generalized Maxwell rheological model. The computational implementation is developed within the finite element framework to analyze the delayed behavior of geomaterials with the presence of isotropically distributed micro-fractures under plane strain conditions. Several examples of applications are presented with the aim to illustrate the performance of the finite element modeling. The assessment of the approach accuracy and the corresponding code verification are performed by comparing the numerical predictions with analytical solutions for simple and complex geo-structures.
DOI: 10.6084/m9.figshare.11267483.v1
title: Intra- and interobserver reliability of a modified distraction test based on digital images to assess lower eyelid horizontal tension

description: ABSTRACT Purpose: Inferior eyelid laxity is classically evaluated using “snap-back” and “distraction” tests. This study aimed to assess the reproducibility of the technique used to indirectly quantify the horizontal tension in the lower eyelids using digital image processing. Methods: This longitudinal study was conducted to assess the reproducibility of a new technique that quantifies the horizontal tension in the lower eyelid. The study was conducted at the Hospital das Clínicas of Porto Alegre. The protocol was established by two trained ophthalmologist examiners, allowing intra- and interobserver agreement analyses. Image acquisition was done in two stages: the first image was captured with the eyelid in primary gaze position and the second with the eyelid in traction position. All images and measurements were processed using Image J 1.33m software from the National Institute of Health. The Bland-Altman method, intraclass correlation coefficients, concordance correlation coefficients, and technical measurement error were used to evaluate reproducibility. Results: The study participants comprised healthy individuals with no ophthalmologic pathologies. The measurements obtained in the neutral position showed a slightly higher agreement than those obtained in the traction position. The mean difference between the measurements performed in the traction position was 0.028 ± 0.7 mm and 0.014 ± 0.9 mm in the intra- and interobserver analyses, respectively. The Bland-Altman method demonstrated adequate confidence limits for both measurements. Correlation coefficients for measurements varied between 0.87 [95% confidence interval (CI) 0.68-0.95] and 0.91 (95% CI 0.77-0.97) in the neutral position and between 0.72 (95% CI 0.37-0.89) and 0.76 (95% CI 0.4-0.91) in the traction position. Conclusion: A high intra- and interobserver concordance was observed in the studied method to quantify lower eyelid tension. The proposed method is simple and easily reproducible, and to the best our knowledge, this is the first method that quantifies lower eyelid horizontal tension on the basis of digital image processing. This modified distraction test might be useful in studies quantifying lower eyelid horizontal tension.
DOI: 10.6084/m9.figshare.11267486.v1
title: Influence of the addition of KCl and CaCl2 blends on the physicochemical parameters of salted meat products throughout the processing steps

description: Abstract The objective of this study was to evaluate the effects of different chloride salts (NaCl, KCl, and CaCl2) on the characteristics of salted meat products through the determination of moisture, pH, aw, chloride, ash levels, cooking loss, and instrumental color during the processing steps. Four salted meat treatments were elaborate using the following salts in the wet and dry salting steps: FC1: 100% NaCl; F1: 50% NaCl + 50% KCl; F2: 50% NaCl + 25% CaCl2; F3: 50% NaCl + 25% KCl + 25% CaCl2. The addition of CaCl2 led to the lowest pH and changes in aw, moisture, ash levels, and instrumental color when compared to the other treatments, which was different from the control (100% NaCl) and F1 (50% NaCl + 50% KCl), thus evidencing the great effect of CaCl2 on the characteristics of salted meat products during the whole processing. The partial replacement of NaCl by KCl and/or CaCl2 greatly increased the cooking loss of salted meat products. The replacement of NaCl by KCl promoted similar quality parameters.
DOI: 10.6084/m9.figshare.11267495.v1
title: Effects of Laser Remelting Process on Microstructure and Wear Behavior of WC Coating Sprayed by HVOF

description: ABSTRACT The wear of industrial and agricultural components and equipment represents a major factor of depreciation of capital and source of expenses with maintenance and replacement of mechanical components. As the wear is an essentially superficial phenomenon, involving the undesirable mechanical removal of surface materials, the solution studied in this work was to analyze the abrasive wear behavior of a surface coated with Tungsten Carbide (WC) sprayed by the thermal spray method by High Velocity Oxygen Fuel - HVOF on a SAE 1020 steel substrate. To improve the adhesion between the coating and substrate, to reduce the porosity present in the coating and to obtain better results in the abrasive wear test, a CO2 laser treatment with a power of 125 W was applied to the surface of the WC coating. The samples coated by HVOF and HVOF + CO2 laser treatment were characterized by Scanning Electron Microscopy (SEM) to evaluate the morphology and microstructure of the coating and interface, microhardness analysis, wear and roughness test were done. It was obtained as a result that the sample coated by the HVOF method showed a better performance in tests of microhardness, wear and roughness compared to the sample treated with the laser.
DOI: 10.6084/m9.figshare.11267462
title: Optical coherence tomography angiography findings in patients with branch retinal vein occlusion treated with Anti-VEGF

description: ABSTRACT Purpose: To investigate retinal microvasculature changes in patients treated with anti-VEGF for macular edema secondary to branch retinal vein occlusion. Methods: We examined 38 eyes of 19 patients for the study. We measured superficial and deep capillary plexus vessel densities (%), foveal avascular zone areas (mm2), and central macular thicknesses. Results: Parafoveal superficial and deep capillary plexus values were significantly lower in eyes with branch retinal vein occlusion than in fellow eyes (p&lt;0.001). We found a significant increase in parafoveal deep capillary plexus values after the anti-VEGF treatment (p=0.032). The mean foveal avascular zone was larger in eyes with branch retinal vein occlusion than in control eyes (p&lt;0.001). The mean central macular thickness was significantly higher in eyes with branch retinal vein occlusion than in controls, and we observed a significant decrease in central macular thickness after anti-VEGF treatment (&lt;0.001). In addition, the cystic structures in the deep capillary plexus regressed. Conclusion: Optical coherence tomography angiography enables qualitative and quantitative evaluations during follow-up of patients treated for branch retinal vein occlusion.
DOI: 10.6084/m9.figshare.11267471
title: Extract of Ellagitannins starting with Strawberries (Fragaria sp.) and Blackberries (Rubus sp.)

description: Abstract Characterize the content of phytochemical compounds present in samples of extracts of strawberry (Fragaria sp.) and blackberry (Rubus sp.). The extraction of said compounds was carried out with solutions of polar solvents, such as acetone, ethanol and methanol, using an experimental design with three factors: state of maturity, resting time and temperature. The characterization of these fruits is the beginning of the utilization mainly of ellagitannins to produce ellagic acid. Total phytochemical content was determined by spectrophotometric techniques, for phenolic content it was used Folin-Ciocalteu, for flavonoids it was determined with aluminium chloride, the antioxidant activity was evaluated by the methods of DPPH and ABTS+, the bactericidal effect of the extracts was shown for strains of E. coli and S. aureus. The determination of ellagitannins was performed by spectrometry. The influence of the state of maturity on the response variable was evaluated; it was observed that concentration of phytochemicals increases proportionally to maturity stage. The antioxidant activity was evaluated, determining that extracts obtained exhibit 94% - 95% inhibition. The determination of ellagitannins, finding that the highest concentration of ellagitannins was found in a state of green maturity, for strawberries as well as blackberries.
DOI: 10.6084/m9.figshare.11267477
title: Analysis of the alkalinity reduction of the wood-cement composites in the function of the partial replacement of the Portland cement by pozzolans

description: ABSTRACT The objective of this research was to evaluate the alkalinity reduction of the wood-cement composites produced with Portland cement and residual particles of Pinus spp., as a function of the gradual replacement of the Portland cement by the pozzolans silica fume (SA) metakaolin (MK), fly ash (CV), blast slag furnace (EAF), rice husk ash (CCA) and calcined ceramic residue (RCC). For this, 5 cm diameter cylindrical specimens were produced with composites wiyh 100% Portland cement and residual Pinus spp. particles, adopted as reference and with partial cement replacements by 0%, 5%, 10%, 15% and 20% of SA, 0%, 10%, 20%, 30% e 40% de MK, CV, CCA e RCC e 0%, 30%, 40%, 50% e 60% de EAF. The Pinus spp. residue initially underwent pre-treatment type extraction in cold water for a period of 24 hours to improve compatibility with the cementitious matrix. In the production of the composites a superplasticizer additive of 1st generation was used, based on lignosulphonates, naphthalenes and melanins in contents ranging from 0.20% to 7.8% of the cement and pozzolan and content and hydrated calcium chloride (CaCl2.2H2O) was used with accelerator additive in amounts ranging from 0% to 4.5% calculated in mass in relation to the cement content of the composites. The composites were immersed for a period of 91 days and after that period were grounded and added to the deionized water, and the pH was determined through the equilibrium solution. Significant reductions in the pH of the composites were determined in relation to the pH value of the reference composite (12.67) of the order of 10.02% (20% de SA, with 4.5% of CaCl2.2H2O and 4.4% of SP), 12.55% (40% de MK, with 4.5% of CaCl2.2H2O and 7.8% of SP), 5.13% (40% of CVwith 4.5% of CaCl2.2H2O), 3.87% (60% of EAF with 4.5% of CaCl2.2H2O), 15.15% (40% of CCA, with 4.5% of CaCl2.2H2O and 4.2%of SP) and 8.29% (40% of RCC, with 4.5% of CaCl2.2H2O and 2.6% of SP).