cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.8848346
title: TEACHING-SERVICE INTEGRATION IN THE TRAINING OF PROFESSIONALS FOR PUBLIC HEALTH SYSTEMS

description: Abstract Teaching-service integration, understood through the combined work of students, teachers and workers in a practice setting, has as its goals excellency in professional training and quality of the work in health. The goal of the study is to analyze, through the perception of the students, the teaching-service integration, which takes place during the undergraduate Pharmacy studies. It is a quantitative study conducted in 2018, and characterized as a cross-sectional survey in which a structured questionnaire was applied. A total of 155 undergraduate Pharmacy students, enrolled in three different universities, a private university and two public ones, located in the metropolitan region of the city of Porto Alegre, in the state of Rio Grande do Sul, Brazil, participated in the study. The results found indicate the potentialities of the internships in public health settings for the training of Pharmacy professionals who are more confident regarding their future work at the Brazilian Unified Health System. The data obtained reveal the variable age of the students as a relevant factor for the acknowledgement of the competencies needed for the job. Such findings may contribute to the process of development or reformulation of the syllabi of the Pharmacy undergraduate courses, with the goal of training professionals who are critical, thoughtful and knowledgeable regarding the local health reality.
DOI: 10.6084/m9.figshare.8848349.v1
title: An animal experimental study of porous magnesium scaffold degradation and osteogenesis

description: Our objective was to observe the biodegradable and osteogenic properties of magnesium scaffolding under in vivo conditions. Twelve 6-month-old male New Zealand white rabbits were randomly divided into two groups. The chosen operation site was the femoral condyle on the right side. The experimental group was implanted with porous magnesium scaffolds, while the control group was implanted with hydroxyapatite scaffolds. X-ray and blood tests, which included serum magnesium, alanine aminotransferase (ALT), creatinine (CREA), and blood urea nitrogen (BUN) were performed serially at 1, 2, and 3 weeks, and 1, 2, and 3 months. All rabbits were killed 3 months postoperatively, and the heart, kidney, spleen, and liver were analyzed with hematoxylin and eosin (HE) staining. The bone samples were subjected to microcomputed tomography scanning (micro-CT) and hard tissue biopsy. SPSS 13.0 (USA) was used for data analysis, and values of P&lt;0.05 were considered to be significant. Bubbles appeared in the X-ray of the experimental group after 2 weeks, whereas there was no gas in the control group. There were no statistical differences for the serum magnesium concentrations, ALT, BUN, and CREA between the two groups (P&gt;0.05). All HE-stained slices were normal, which suggested good biocompatibility of the scaffold. Micro-CT showed that magnesium scaffolds degraded mainly from the outside to inside, and new bone was ingrown following the degradation of magnesium scaffolds. The hydroxyapatite scaffold was not degraded and had fewer osteoblasts scattered on its surface. There was a significant difference in the new bone formation and scaffold bioabsorption between the two groups (9.29±1.27 vs 1.40±0.49 and 7.80±0.50 vs 0.00±0.00 mm3, respectively; P&lt;0.05). The magnesium scaffold performed well in degradation and osteogenesis, and is a promising material for orthopedics.
DOI: 10.6084/m9.figshare.8848337
title: 4D-QSAR Study of 17β-Hydroxysteroid Dehydrogenase Type 3 Inhibitors

description: Prostate cancer is one of the most common form of cancer among men, and its incidence has been increasing progressively. Since the prostate depends on androgenic hormones to regulate its growth and development, interference with androgenic biosynthesis are important to control the disease. Thus, in this work, a 4D-quantitative structure-activity relationship (QSAR) receptor independent study was carried out using the Laboratório de Quimiometria Teórica e Aplicada (LQTA)-QSAR approach and the new tool Web-4D-QSAR with a set of benzylidene oxazolidinedione and thiazolidinedione inhibitor of the 17β-hydroxysteroid dehydrogenase type 3. The obtained model is robust, free from chance correlation, and with good predictability in all tests performed. In addition to this result, a good mecanistic interpretation related to the binding with the biological target could be traced, which strengthens its potential application in virtual screening and design of new inhibitors of the studied enzyme with the possibility of use in the pharmacological treatment of prostate cancer.
DOI: 10.6084/m9.figshare.8848340
title: Knowledge sharing in the automotive sector: a comparative study of chinese and brazilian firms

description: Abstract Paper aims This research aims to evaluate factors that influence knowledge sharing in automotive production context in Brazil and China. Originality Despite the growing recognition of the factors that enable knowledge sharing in organizations, our understanding about the unique challenges encountered by the blue-collar workers in a production context is rather limited. Also, the paper raises issues and challenges involved for production organizations to engage in cross-national knowledge sharing, which remain relatively under-explored. Research method Drawing on the Analytic Hierarchy Process (AHP) approach, we conduct a comparative survey among the production managers in five automotive plants in China and Brazil. The AHP approach is based on Objective: Promote knowledge sharing among production workers; Criteria of knowledge conversion as Socialization, Externalization, Internalization; and Alternatives as Structure, Communication, Training, Incentive, Standard Operating Procedure, Problem Solving Methodology. The methodology focused on the 3 Brazilian and 2 Chinese automotive plants in our fieldwork. Main findings While many authors argue that socialization (dialogue) is the key form of worker knowledge sharing, our findings indicate that workers and managers perceive internalisation as more important in the automotive context. The significant differences between Chinese and Brazilian workers on the relative importance they attributed to knowledge sharing processes and corresponding enabling factors reinforce our understanding about the challenges of knowledge sharing across cultures and lends support to a more particularistic debate of knowledge management. While automotive workers in Brazil preferred to receive more training and better incentive schemes as essential knowledge sharing support mechanisms, Chinese workers valued more standardization through structure and standard operation procedures. The study reaffirms the role of knowledge sharing in continuous improvement and incremental innovation in shop floor operations. Implications for theory and practice In lieu of the gaps in the extant literature, this research aims to further identify and evaluate factors that influence cross-national knowledge sharing in automotive production contexts. The research addressed the gaps to promote supportive ways to provide employees interaction, best practices and lessons learning sharing.
DOI: 10.6084/m9.figshare.8848343.v1
title: BDD-Electrolysis of Oxalic Acid in Diluted Acidic Solutions

description: Boron doped diamond films (BDD) are the most studied electrocatalytic materials and their efficiency for removing organic compounds is attributed to their ability to produce a large amount of hydroxyl radicals by the electrolysis of water. However, some organic compounds are easy to degrade than others, as well as they also interact with BDD surface. Thus, it is necessary to understand the chemical/electrochemical process at the molecular level. In this frame, this work aims to study the electrochemical oxidation (EO) of oxalic acid (OA) at BDD anode, understanding the reaction mechanism, formation of hydroxyl radicals, the effect of supporting electrolyte concentration, and the role of oxidants in solution taking into consideration the cyclic and linear voltammetric measurements. Voltammetric results clearly reveal that a direct electron transfer is achieved as the main mechanistic behavior suffered by OA on BDD surface before oxygen reaction. However, the concentration of sulfates in solution plays an important role in the solvation, diffusion and adsorption species at BDD surface, promoting parallel mechanisms. From the information provided by experimental measurements, the preferential mechanism on BDD surface at low or high overpotential regions was elucidated.
DOI: 10.6084/m9.figshare.8848346.v1
title: TEACHING-SERVICE INTEGRATION IN THE TRAINING OF PROFESSIONALS FOR PUBLIC HEALTH SYSTEMS

description: Abstract Teaching-service integration, understood through the combined work of students, teachers and workers in a practice setting, has as its goals excellency in professional training and quality of the work in health. The goal of the study is to analyze, through the perception of the students, the teaching-service integration, which takes place during the undergraduate Pharmacy studies. It is a quantitative study conducted in 2018, and characterized as a cross-sectional survey in which a structured questionnaire was applied. A total of 155 undergraduate Pharmacy students, enrolled in three different universities, a private university and two public ones, located in the metropolitan region of the city of Porto Alegre, in the state of Rio Grande do Sul, Brazil, participated in the study. The results found indicate the potentialities of the internships in public health settings for the training of Pharmacy professionals who are more confident regarding their future work at the Brazilian Unified Health System. The data obtained reveal the variable age of the students as a relevant factor for the acknowledgement of the competencies needed for the job. Such findings may contribute to the process of development or reformulation of the syllabi of the Pharmacy undergraduate courses, with the goal of training professionals who are critical, thoughtful and knowledgeable regarding the local health reality.
DOI: 10.6084/m9.figshare.8848331
title: Effect of seminal plasma addition from high and low fertility animals on the cryopreservation of epididymal tail and ejaculated sperm from subfertile stallions

description: ABSTRACT The aim of this study was to compare the effect of the addition of seminal plasma from high and low fertility stallions on sperm viability of frozen-thawed sperm cells from ejaculate and from epididymal tail of subfertile stallions. Six stallions with a history of subfertility were used. After collection, ejaculate spermatozoa were divided into three aliquots: Botu-Semen® (EJ-CT); High-quality seminal plasma (EJ-PS1); Low-quality seminal plasma (EJ-PS2). The same was done with sperm cells from epididymis tail after orchiectomy (EP-CT; EP-PS1; EP-PS2). Evaluations of sperm kinetics were assessed by CASA and membrane and acrosome integrity, DNA fragmentation, sperm capacitation and sperm peroxidation were assessed by flow cytometry. After thawing, no differences were observed between ejaculated sperm (EJ) and epididymal sperm (EP) in any CASA evaluations. However, higher (P&lt; 0.05) percentage of cells with intact plasma and acrossomal membranes was observed in EP groups (EP-CT:31.7±7.5b; EP-PS1:35.2±7.0b; EP-PS2:33.9±7.2b) compared to EJ groups (EJ-CT:15.1±4.9a, EJ-PS1:11.7±4.5a, EJ-PS2:13.1±5,2a). In addition, differences in DNA fragmentation index were observed (EJ-CT:2.6±0.6a; EJ-PS1:2.4±0.8a; EJ-PS2:3.0±0.8a; CT:1.4±0.4b; EP-PS1:1.2±0.3b; EP-PS2:1.3±0.2b). It was concluded that the addition of 20% seminal plasma from fertile or subfertile animals prior to the freezing of epididymal spermatozoa from subfertile animals does not interfere in sperm quality.
DOI: 10.6084/m9.figshare.8848337.v1
title: 4D-QSAR Study of 17β-Hydroxysteroid Dehydrogenase Type 3 Inhibitors

description: Prostate cancer is one of the most common form of cancer among men, and its incidence has been increasing progressively. Since the prostate depends on androgenic hormones to regulate its growth and development, interference with androgenic biosynthesis are important to control the disease. Thus, in this work, a 4D-quantitative structure-activity relationship (QSAR) receptor independent study was carried out using the Laboratório de Quimiometria Teórica e Aplicada (LQTA)-QSAR approach and the new tool Web-4D-QSAR with a set of benzylidene oxazolidinedione and thiazolidinedione inhibitor of the 17β-hydroxysteroid dehydrogenase type 3. The obtained model is robust, free from chance correlation, and with good predictability in all tests performed. In addition to this result, a good mecanistic interpretation related to the binding with the biological target could be traced, which strengthens its potential application in virtual screening and design of new inhibitors of the studied enzyme with the possibility of use in the pharmacological treatment of prostate cancer.
DOI: 10.6084/m9.figshare.8848340.v1
title: Knowledge sharing in the automotive sector: a comparative study of chinese and brazilian firms

description: Abstract Paper aims This research aims to evaluate factors that influence knowledge sharing in automotive production context in Brazil and China. Originality Despite the growing recognition of the factors that enable knowledge sharing in organizations, our understanding about the unique challenges encountered by the blue-collar workers in a production context is rather limited. Also, the paper raises issues and challenges involved for production organizations to engage in cross-national knowledge sharing, which remain relatively under-explored. Research method Drawing on the Analytic Hierarchy Process (AHP) approach, we conduct a comparative survey among the production managers in five automotive plants in China and Brazil. The AHP approach is based on Objective: Promote knowledge sharing among production workers; Criteria of knowledge conversion as Socialization, Externalization, Internalization; and Alternatives as Structure, Communication, Training, Incentive, Standard Operating Procedure, Problem Solving Methodology. The methodology focused on the 3 Brazilian and 2 Chinese automotive plants in our fieldwork. Main findings While many authors argue that socialization (dialogue) is the key form of worker knowledge sharing, our findings indicate that workers and managers perceive internalisation as more important in the automotive context. The significant differences between Chinese and Brazilian workers on the relative importance they attributed to knowledge sharing processes and corresponding enabling factors reinforce our understanding about the challenges of knowledge sharing across cultures and lends support to a more particularistic debate of knowledge management. While automotive workers in Brazil preferred to receive more training and better incentive schemes as essential knowledge sharing support mechanisms, Chinese workers valued more standardization through structure and standard operation procedures. The study reaffirms the role of knowledge sharing in continuous improvement and incremental innovation in shop floor operations. Implications for theory and practice In lieu of the gaps in the extant literature, this research aims to further identify and evaluate factors that influence cross-national knowledge sharing in automotive production contexts. The research addressed the gaps to promote supportive ways to provide employees interaction, best practices and lessons learning sharing.
DOI: 10.6084/m9.figshare.8848331.v1
title: Effect of seminal plasma addition from high and low fertility animals on the cryopreservation of epididymal tail and ejaculated sperm from subfertile stallions

description: ABSTRACT The aim of this study was to compare the effect of the addition of seminal plasma from high and low fertility stallions on sperm viability of frozen-thawed sperm cells from ejaculate and from epididymal tail of subfertile stallions. Six stallions with a history of subfertility were used. After collection, ejaculate spermatozoa were divided into three aliquots: Botu-Semen® (EJ-CT); High-quality seminal plasma (EJ-PS1); Low-quality seminal plasma (EJ-PS2). The same was done with sperm cells from epididymis tail after orchiectomy (EP-CT; EP-PS1; EP-PS2). Evaluations of sperm kinetics were assessed by CASA and membrane and acrosome integrity, DNA fragmentation, sperm capacitation and sperm peroxidation were assessed by flow cytometry. After thawing, no differences were observed between ejaculated sperm (EJ) and epididymal sperm (EP) in any CASA evaluations. However, higher (P&lt; 0.05) percentage of cells with intact plasma and acrossomal membranes was observed in EP groups (EP-CT:31.7±7.5b; EP-PS1:35.2±7.0b; EP-PS2:33.9±7.2b) compared to EJ groups (EJ-CT:15.1±4.9a, EJ-PS1:11.7±4.5a, EJ-PS2:13.1±5,2a). In addition, differences in DNA fragmentation index were observed (EJ-CT:2.6±0.6a; EJ-PS1:2.4±0.8a; EJ-PS2:3.0±0.8a; CT:1.4±0.4b; EP-PS1:1.2±0.3b; EP-PS2:1.3±0.2b). It was concluded that the addition of 20% seminal plasma from fertile or subfertile animals prior to the freezing of epididymal spermatozoa from subfertile animals does not interfere in sperm quality.
DOI: 10.6084/m9.figshare.8848313
title: Solid Phase Extraction Using SiO2/Al2O3/TiO2 Ternary Oxide for Cu2+ Preconcentration

description: The present work aims at studying the preconcentration of Cu2+ ions by solid phase extraction using SiO2/Al2O3/TiO2 ternary oxide as adsorbent material. This methodology consists of the affinity of the analyte for the adsorbent material and its subsequent elution with the least amount of solvent. Subsequently, the aqueous phase containing the extracted analyte was collected and analyzed by square wave anodic stripping voltammetry (SW-ASV). For the applied solid phase extraction (SPE) methodology, a complete factorial design was carried out with 3 variables at 2 levels (pH, elution flow rate and analyte concentration) to optimize the extraction conditions. The results showed that at pH 9, the SiO2/Al2O3/TiO2 oxide presents excellent Cu2+ adsorption capacity with recovery values between 81.0 and 104% for this pH range. The limit of detection (LOD) and limit of quantification (LOQ) values were determined to be 1.71 and 5.64 µg L-1, respectively. The study of recovery for SPE method revealed results of 102 and 103%.
DOI: 10.6084/m9.figshare.8848307
title: Assessing the Spatial Distribution of Key Flavonoids in Mentha × piperita Leaves: An Application of Desorption Electrospray Ionization Mass Spectrometry Imaging (DESI-MSI)

description: Desorption electrospray ionization mass spectrometry imaging (DESI-MSI) was used to assess the spatial distribution of some key flavonoids in peppermint (Mentha × piperita L.) leaves. The chemical images were generated by applying DESI-MSI on the peppermint leaves imprinting while acquiring the spectra in the negative ion mode. The following key flavonoids were detected and grouped within well-known biosynthetic routes in plants: naringenin route [naringenin, sakuranetin, hesperetin, hesperidin, luteolin, and apigenin]; luteolin route [luteolin, chrysoeriol, luteolin-7-O-D-glucuronide, luteolin-7-O-D-glucoside, luteolin-7-O-neohesperidoside]; apigenin route [apigenin, apigenin-7-O-gentiobioside, apigenin-7-O-neohesperidoside, thymusin/pilosin, pebrellin, acacetin/genkwanin, ladanein, xanthomicrol/pedunculin/nevadensin]. Maps of the spatial distribution of these flavonoids throughout the peppermint leaves within each route were then displayed. The results described herein comprise an important (although still underexplored) subject that certainly will experience a remarkable growth in the next years.
DOI: 10.6084/m9.figshare.8848313.v1
title: Solid Phase Extraction Using SiO2/Al2O3/TiO2 Ternary Oxide for Cu2+ Preconcentration

description: The present work aims at studying the preconcentration of Cu2+ ions by solid phase extraction using SiO2/Al2O3/TiO2 ternary oxide as adsorbent material. This methodology consists of the affinity of the analyte for the adsorbent material and its subsequent elution with the least amount of solvent. Subsequently, the aqueous phase containing the extracted analyte was collected and analyzed by square wave anodic stripping voltammetry (SW-ASV). For the applied solid phase extraction (SPE) methodology, a complete factorial design was carried out with 3 variables at 2 levels (pH, elution flow rate and analyte concentration) to optimize the extraction conditions. The results showed that at pH 9, the SiO2/Al2O3/TiO2 oxide presents excellent Cu2+ adsorption capacity with recovery values between 81.0 and 104% for this pH range. The limit of detection (LOD) and limit of quantification (LOQ) values were determined to be 1.71 and 5.64 µg L-1, respectively. The study of recovery for SPE method revealed results of 102 and 103%.
DOI: 10.6084/m9.figshare.8848304
title: Evaluation of muscle tissue and liver glycogen of cattle submitted to transport over long distances and subjected to emergency slaughter

description: ABSTRACT The study evaluated the effect of transportation over long distances on cattle muscle tissue of submitted to emergency slaughter in slaughterhouses in northern Tocantins, Brazil. The evaluations consisted in pH, muscle and liver glycogen, muscle histopathology and creatine kinase (CK), alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activity. Animals were placed into two groups: Experimental Group (EG), consisting of 19 bovines intended for immediate emergency slaughter, and Control Group (CG), composed of 24 bovines slaughtered in accordance with the normal flow. CK and ALT levels were high in EG. AST did not differ between groups. EG showed higher muscle pH and mean of degenerate fibers, mainly on the intercostal. However, muscle and liver glycogen did not differ between groups. In conclusion, cattle transported over long distances and subjected to immediate emergency slaughter showed markedly stress condition, with changes in biochemical parameters in the muscle tissue, determined by cellular degeneration.
DOI: 10.6084/m9.figshare.8848307.v1
title: Assessing the Spatial Distribution of Key Flavonoids in Mentha × piperita Leaves: An Application of Desorption Electrospray Ionization Mass Spectrometry Imaging (DESI-MSI)

description: Desorption electrospray ionization mass spectrometry imaging (DESI-MSI) was used to assess the spatial distribution of some key flavonoids in peppermint (Mentha × piperita L.) leaves. The chemical images were generated by applying DESI-MSI on the peppermint leaves imprinting while acquiring the spectra in the negative ion mode. The following key flavonoids were detected and grouped within well-known biosynthetic routes in plants: naringenin route [naringenin, sakuranetin, hesperetin, hesperidin, luteolin, and apigenin]; luteolin route [luteolin, chrysoeriol, luteolin-7-O-D-glucuronide, luteolin-7-O-D-glucoside, luteolin-7-O-neohesperidoside]; apigenin route [apigenin, apigenin-7-O-gentiobioside, apigenin-7-O-neohesperidoside, thymusin/pilosin, pebrellin, acacetin/genkwanin, ladanein, xanthomicrol/pedunculin/nevadensin]. Maps of the spatial distribution of these flavonoids throughout the peppermint leaves within each route were then displayed. The results described herein comprise an important (although still underexplored) subject that certainly will experience a remarkable growth in the next years.