cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.11821929
title: Raw data - Iuri et al PeerJ 2020.rar

description: Raw data:Figure 2 - fcs files, raw spreadsheet data, statisticsFigure 3 - raw spreadsheet data, array dataset, statisticsFigure 4 - original gels, raw spreadsheet data, statisticsFigure 5 - original images, raw spreadsheet data, statisticsFigure 6 - original images, raw spreadsheet data, statisticsFigure 7 - raw spreadsheet data, statisticsFigure 8 - original imagesFigure 9 - raw spreadsheet data, statisticsFigure 10 - original gels, raw spreadsheet data, statisticsFigure 11 - original images, raw spreadsheet data, statistics
DOI: 10.6084/m9.figshare.11821929.v1
title: Raw data - Iuri et al PeerJ 2020.rar

description: Raw data:Figure 2 - fcs files, raw spreadsheet data, statisticsFigure 3 - raw spreadsheet data, array dataset, statisticsFigure 4 - original gels, raw spreadsheet data, statisticsFigure 5 - original images, raw spreadsheet data, statisticsFigure 6 - original images, raw spreadsheet data, statisticsFigure 7 - raw spreadsheet data, statisticsFigure 8 - original imagesFigure 9 - raw spreadsheet data, statisticsFigure 10 - original gels, raw spreadsheet data, statisticsFigure 11 - original images, raw spreadsheet data, statistics
DOI: 10.6084/m9.figshare.11821767
title: Laccaria bicolor Mobilizes both Labile Aluminum and Inorganic Phosphate in Rhizosphere Soil of Pinus massoniana Seedlings Field-grown in a Yellow Acidic Soil.xlsx

description: 4-week-old <i>Pinus massoniana</i> seedlings were inoculated with three ectomycorrhizal<i> </i>isolates (<i>Laccaria bicolor</i> 270, <i>L. bicolor </i>S238A and <i>L. bicolor</i> S238N), respectively, and grown in a Haplic Alisol field with or without Al treatment for 12 weeks. After 12 weeks of Al treatment, 25 16-week-old seedlings were selectively harvested and then these data described in the dataset were determined.
DOI: 10.6084/m9.figshare.11821767.v1
title: Laccaria bicolor Mobilizes both Labile Aluminum and Inorganic Phosphate in Rhizosphere Soil of Pinus massoniana Seedlings Field-grown in a Yellow Acidic Soil.xlsx

description: 4-week-old <i>Pinus massoniana</i> seedlings were inoculated with three ectomycorrhizal<i> </i>isolates (<i>Laccaria bicolor</i> 270, <i>L. bicolor </i>S238A and <i>L. bicolor</i> S238N), respectively, and grown in a Haplic Alisol field with or without Al treatment for 12 weeks. After 12 weeks of Al treatment, 25 16-week-old seedlings were selectively harvested and then these data described in the dataset were determined.
DOI: 10.6084/m9.figshare.11821641
title: A new Cu(II)-based metal-organic framework constructed from the terpyridine tetrazolate ligand: structural characterization and anticancer activity on nasopharyngeal carcinoma

description: In the current study, a new Cu(II)-based metal-organic framework (MOF) formulated as {[Cu<sub>3</sub>(L)<sub>6</sub>(H<sub>2</sub>O)]·(H<sub>2</sub>O)<sub>4</sub>}<sub>n</sub> (<b>1</b>) (L = 4-(tetrazol-5-yl)phenyl-4,2′:6′,4″-terpyridine), has been synthesized by a solvothermal method and structurally characterized via the single crystal X-ray diffraction, elemental analysis, powder X-ray diffraction along with the thermogravimetric analysis. After the synthesis of the compound <b>1</b>, its inhibitory effect on the viability of CNE-1 nasopharyngeal cancer cells were detected. Firstly, the Cell Counting Kit-8 (CCK-8) was performed to determine the anti-cancer activity of compound <b>1</b> <i>in vitro</i>, as well as the half maximal inhibitory concentration (IC<sub>50</sub>) value of compound <b>1</b>. In addition to this, Annexin V-FITC/PI assay was conducted the apoptosis of CNE-1 cells after compound <b>1</b> treatment. The H2DCF-DA assay was carried out to measure the ROS accumulation in CNE-1 cells after compound <b>1</b> treatment.
DOI: 10.6084/m9.figshare.11821641.v1
title: A new Cu(II)-based metal-organic framework constructed from the terpyridine tetrazolate ligand: structural characterization and anticancer activity on nasopharyngeal carcinoma

description: In the current study, a new Cu(II)-based metal-organic framework (MOF) formulated as {[Cu<sub>3</sub>(L)<sub>6</sub>(H<sub>2</sub>O)]·(H<sub>2</sub>O)<sub>4</sub>}<sub>n</sub> (<b>1</b>) (L = 4-(tetrazol-5-yl)phenyl-4,2′:6′,4″-terpyridine), has been synthesized by a solvothermal method and structurally characterized via the single crystal X-ray diffraction, elemental analysis, powder X-ray diffraction along with the thermogravimetric analysis. After the synthesis of the compound <b>1</b>, its inhibitory effect on the viability of CNE-1 nasopharyngeal cancer cells were detected. Firstly, the Cell Counting Kit-8 (CCK-8) was performed to determine the anti-cancer activity of compound <b>1</b> <i>in vitro</i>, as well as the half maximal inhibitory concentration (IC<sub>50</sub>) value of compound <b>1</b>. In addition to this, Annexin V-FITC/PI assay was conducted the apoptosis of CNE-1 cells after compound <b>1</b> treatment. The H2DCF-DA assay was carried out to measure the ROS accumulation in CNE-1 cells after compound <b>1</b> treatment.
DOI: 10.6084/m9.figshare.11821608
title: Supplementary Material for: Translation of Digital Health Technologies to Advance Precision Medicine: Informing Regulatory Science

description: The proliferation of digital technologies and the application of sophisticated data analysis techniques are increasingly viewed as having the potential to transform translational research and precision medicine. While digital technologies are rapidly applied in innovative ways to develop new diagnostics and therapies, the ultimate approval and adoption of these emerging methods presents several scientific and regulatory challenges. To better understand and address these regulatory science gaps, a working group of the Clinical and Translational Science Awards Program convened the Regulatory Science to Advance Precision Medicine Forum focused on digital health, particularly examining gaps in the use, validation, and interpretation of data from sensors that collect and tools that analyze digital biomarkers. The key findings and recommendations provided here emerged from the Forum and include the need to enhance areas related to data standards, data quality and validity, knowledge management, and building trust between all stakeholders.
DOI: 10.6084/m9.figshare.11821656
title: Downregulation of MiR-218 can alleviate high-glucose-induced renal proximal tubule injury by targeting GPRC5A

description: The purpose of this study was to explore the functional implication of microRNA-218 (miR-218) in diabetic nephropathy (DN) through high-glucose-stimulated renal proximal tubule impairment. Biological function experiments showed that miR-218 and inflammatory factors TNF-α and IL-1β were highly expressed in renal proximal tubule under high-glucose conditions. Inhibiting miR-218 alleviated renal tubular cell injury, which was represented by miR-218 inhibitor facilitating renal tubular cell vitality whilst reducing its apoptosis and levels of inflammation factors. In addition, we confirmed that miR-218 directly targeted GPRC5A and negatively regulated its expression. Co-transfection assay showed that overexpression of GPRC5A accentuated the mitigated action of miR-218 inhibitor on renal proximal tubule cell injury induced by high-glucose. Accordingly, these data indicated that downregulation of miR-218 can assuage high-glucose-resulted renal tubular cell damage, and its ameliorative effect was achieved by negative regulation of GPRC5A, which provides a novel direction for unearthing the pathogenesis and even further biological treatment of DN. MiR-218/GPRC5 axis contributes to HK-2 cell viability and apoptosis under high-glucose conditions.
DOI: 10.6084/m9.figshare.11821656.v1
title: Downregulation of MiR-218 can alleviate high-glucose-induced renal proximal tubule injury by targeting GPRC5A

description: The purpose of this study was to explore the functional implication of microRNA-218 (miR-218) in diabetic nephropathy (DN) through high-glucose-stimulated renal proximal tubule impairment. Biological function experiments showed that miR-218 and inflammatory factors TNF-α and IL-1β were highly expressed in renal proximal tubule under high-glucose conditions. Inhibiting miR-218 alleviated renal tubular cell injury, which was represented by miR-218 inhibitor facilitating renal tubular cell vitality whilst reducing its apoptosis and levels of inflammation factors. In addition, we confirmed that miR-218 directly targeted GPRC5A and negatively regulated its expression. Co-transfection assay showed that overexpression of GPRC5A accentuated the mitigated action of miR-218 inhibitor on renal proximal tubule cell injury induced by high-glucose. Accordingly, these data indicated that downregulation of miR-218 can assuage high-glucose-resulted renal tubular cell damage, and its ameliorative effect was achieved by negative regulation of GPRC5A, which provides a novel direction for unearthing the pathogenesis and even further biological treatment of DN. MiR-218/GPRC5 axis contributes to HK-2 cell viability and apoptosis under high-glucose conditions.
DOI: 10.6084/m9.figshare.11821551
title: Supplementary Material for: Evaluation of Biodegradable Stent Graft Coatings in Pig and Rabbit Models

description: <b><i>Aims:</i></b> Percutaneous coronary intervention is routinely performed to treat occlusive coronary artery disease. Coronary perforation is a potential complication and can be treated with a stent graft. Current stent grafts are associated with high restenosis rates. We tested the safety and feasibility of biodegradable stent grafts in pig and rabbit models. <b><i>Methods and Results:</i></b> Stent grafts were examined in pig coronaries with repeated OCT imaging for 42 days. Novel biodegradable coatings were applied on a bare metal stent by either an electrospinning (ES) or dip coating (DC) method. A completely biodegradable system was made by ES coating a magnesium-based stent. A commercially available stent graft served as a control. ES devices showed less restenosis (44.3 ± 8.8 vs. 59.1 ± 11.1% in controls, <i>p</i> &lt; 0.05) and smaller reduction in minimum lumen area (44.3 ± 13.4 vs. 64.4 ± 13.6% in controls, <i>p</i> &lt; 0.05) at day 42. DC devices occluded during follow-up. ES devices showed recanalization through the graft wall at day 42. Feasibility of the ES and DC devices was evaluated in pig coronary aneurysms and rabbit aortic perforation models and sealed aneurysms and perforations without complications. <b><i>Conclusions:</i></b> Recanalization of the graft wall improves biocompatibility. Biodegradable stent grafts may present an alternative to permanent implants by showing reduced restenosis at day 42.
DOI: 10.6084/m9.figshare.11821551.v1
title: Supplementary Material for: Evaluation of Biodegradable Stent Graft Coatings in Pig and Rabbit Models

description: <b><i>Aims:</i></b> Percutaneous coronary intervention is routinely performed to treat occlusive coronary artery disease. Coronary perforation is a potential complication and can be treated with a stent graft. Current stent grafts are associated with high restenosis rates. We tested the safety and feasibility of biodegradable stent grafts in pig and rabbit models. <b><i>Methods and Results:</i></b> Stent grafts were examined in pig coronaries with repeated OCT imaging for 42 days. Novel biodegradable coatings were applied on a bare metal stent by either an electrospinning (ES) or dip coating (DC) method. A completely biodegradable system was made by ES coating a magnesium-based stent. A commercially available stent graft served as a control. ES devices showed less restenosis (44.3 ± 8.8 vs. 59.1 ± 11.1% in controls, <i>p</i> &lt; 0.05) and smaller reduction in minimum lumen area (44.3 ± 13.4 vs. 64.4 ± 13.6% in controls, <i>p</i> &lt; 0.05) at day 42. DC devices occluded during follow-up. ES devices showed recanalization through the graft wall at day 42. Feasibility of the ES and DC devices was evaluated in pig coronary aneurysms and rabbit aortic perforation models and sealed aneurysms and perforations without complications. <b><i>Conclusions:</i></b> Recanalization of the graft wall improves biocompatibility. Biodegradable stent grafts may present an alternative to permanent implants by showing reduced restenosis at day 42.
DOI: 10.6084/m9.figshare.11821512
title: Zero/one-dimensional coordination complexes constructed from the carboxylate and multi-nitrogen chelating ligands: structural insights and photocatalytic degradation of organic dye

description: In the current study, two new coordination complexes with the chemical formulae of [Co(cbba)(bimb)](H<sub>2</sub>O) (<b>1</b>, H<sub>2</sub>cbba = 3-((3-carboxybenzyl)oxy)benzoic acid, bimb = 6,6′-bis(1H-benzo[d]imidazol-2-yl)-2,2’-bipyridine) and {[Co(pdc)(bimb)](DMF)}<sub>n</sub> (<b>2</b>, H<sub>2</sub>pda = pyrazine-2,5-dicarboxylic acid) have been successfully prepared by reaction of the Co(NO<sub>3</sub>)<sub>2</sub>·6H<sub>2</sub>O with the bimb ligand in the presence of different carboxylate ligands (H<sub>2</sub>cbba for <b>1</b> and H<sub>2</sub>pda for <b>2</b>). The as-prepared two complexes have been determined via the elemental analysis, single crystal X-ray diffraction along with the powder X-ray diffraction. In addition, the photocatalytic activity of complex <b>2</b> toward the degradation of methyl violet (MV) in simulated polluted water was explored.
DOI: 10.6084/m9.figshare.11821509
title: Two Co(II)-based coordination polymers: structural diversity and treatment activity on chronic primary glomerulonephritis by reducing ROS accumulation and inflammatory response in glomerular epithelial cells

description: Two new three-dimensional (3 D) cobalt-based coordination polymers [Co(L)(5-hypa)]<sub>n</sub> (<b>1</b>, H<sub>2</sub>hypa = 5-hydroxyisophthalic acid), and [Co(L)(1,4-NDC)]<sub>n</sub> (<b>2</b>, 1,4-H<sub>2</sub>NDC = naphthalene-1,4-dicarboxylic acid) have been successfully prepared by using the 3,6-bis(N-imidazolyl) pyridazine (L) and different carboxylate ligands as co-linkers. In the biological study, the treatment effect of compounds <b>1</b> and <b>2</b> on CPGN was evaluated <i>in vivo</i> and <i>in vitro</i>. After the construction of the CPGN animal model, compounds <b>1</b> and <b>2</b> were given for treatment. The relative expression of the <i>TGFβ</i> and <i>1Smad</i> in the glomerular epithelial cells was measured by RT-PCR. The ROS accumulation in the glomerular epithelial cells was detected by ROS detection kit.
DOI: 10.6084/m9.figshare.11821512.v1
title: Zero/one-dimensional coordination complexes constructed from the carboxylate and multi-nitrogen chelating ligands: structural insights and photocatalytic degradation of organic dye

description: In the current study, two new coordination complexes with the chemical formulae of [Co(cbba)(bimb)](H<sub>2</sub>O) (<b>1</b>, H<sub>2</sub>cbba = 3-((3-carboxybenzyl)oxy)benzoic acid, bimb = 6,6′-bis(1H-benzo[d]imidazol-2-yl)-2,2’-bipyridine) and {[Co(pdc)(bimb)](DMF)}<sub>n</sub> (<b>2</b>, H<sub>2</sub>pda = pyrazine-2,5-dicarboxylic acid) have been successfully prepared by reaction of the Co(NO<sub>3</sub>)<sub>2</sub>·6H<sub>2</sub>O with the bimb ligand in the presence of different carboxylate ligands (H<sub>2</sub>cbba for <b>1</b> and H<sub>2</sub>pda for <b>2</b>). The as-prepared two complexes have been determined via the elemental analysis, single crystal X-ray diffraction along with the powder X-ray diffraction. In addition, the photocatalytic activity of complex <b>2</b> toward the degradation of methyl violet (MV) in simulated polluted water was explored.
DOI: 10.6084/m9.figshare.11821509.v1
title: Two Co(II)-based coordination polymers: structural diversity and treatment activity on chronic primary glomerulonephritis by reducing ROS accumulation and inflammatory response in glomerular epithelial cells

description: Two new three-dimensional (3 D) cobalt-based coordination polymers [Co(L)(5-hypa)]<sub>n</sub> (<b>1</b>, H<sub>2</sub>hypa = 5-hydroxyisophthalic acid), and [Co(L)(1,4-NDC)]<sub>n</sub> (<b>2</b>, 1,4-H<sub>2</sub>NDC = naphthalene-1,4-dicarboxylic acid) have been successfully prepared by using the 3,6-bis(N-imidazolyl) pyridazine (L) and different carboxylate ligands as co-linkers. In the biological study, the treatment effect of compounds <b>1</b> and <b>2</b> on CPGN was evaluated <i>in vivo</i> and <i>in vitro</i>. After the construction of the CPGN animal model, compounds <b>1</b> and <b>2</b> were given for treatment. The relative expression of the <i>TGFβ</i> and <i>1Smad</i> in the glomerular epithelial cells was measured by RT-PCR. The ROS accumulation in the glomerular epithelial cells was detected by ROS detection kit.
DOI: 10.6084/m9.figshare.11821170
title: soil respiration, measured by using automated dynamic closed chamber. in a warm temperate broad-leaved forest in Japan

description: Data includes timestamps, soil respiration measuremed by using automated dynamic closed chamber, soil temperature and soil moisture.
DOI: 10.6084/m9.figshare.11821062
title: Additional file 9 of A transcriptomic and proteomic atlas of expression in the Nezara viridula (Heteroptera: Pentatomidae) midgut suggests the compartmentalization of xenobiotic metabolism and nutrient digestion

description: Additional file 9: Table S5. Other Stink Bug Transcriptomes. A table showing information regarding the other stink bug transcriptomes used in this study. A unigene set was obtained from the sequenced H. halys genome while the other three stink bugs were assembled de novo using the same pipeline that was used for N. viridula. Accession numbers can be found in column 3.
DOI: 10.6084/m9.figshare.11821062.v1
title: Additional file 9 of A transcriptomic and proteomic atlas of expression in the Nezara viridula (Heteroptera: Pentatomidae) midgut suggests the compartmentalization of xenobiotic metabolism and nutrient digestion

description: Additional file 9: Table S5. Other Stink Bug Transcriptomes. A table showing information regarding the other stink bug transcriptomes used in this study. A unigene set was obtained from the sequenced H. halys genome while the other three stink bugs were assembled de novo using the same pipeline that was used for N. viridula. Accession numbers can be found in column 3.
DOI: 10.6084/m9.figshare.11821053
title: Additional file 7 of A transcriptomic and proteomic atlas of expression in the Nezara viridula (Heteroptera: Pentatomidae) midgut suggests the compartmentalization of xenobiotic metabolism and nutrient digestion

description: Additional file 7:Â Table S3. Transcript TPMs. A full table of all unigenes identified in this study with their predicted expression (average TPM values across 4 samples) are shown for each midgut compartment along with an annotation based on Uniref50. Corresponding sequences for transcripts can be found in the bioproject PRJNA557118.
DOI: 10.6084/m9.figshare.11821056
title: Additional file 8 of A transcriptomic and proteomic atlas of expression in the Nezara viridula (Heteroptera: Pentatomidae) midgut suggests the compartmentalization of xenobiotic metabolism and nutrient digestion

description: Additional file 8:Â Table S4. Full proteome. A full table of all unigenes identified in this study with an indication of whether the unigene was detected in the proteome of a given tissue. Corresponding sequences for transcripts can be found in the bioproject PRJNA557118.
DOI: 10.6084/m9.figshare.11821050
title: Additional file 6 of A transcriptomic and proteomic atlas of expression in the Nezara viridula (Heteroptera: Pentatomidae) midgut suggests the compartmentalization of xenobiotic metabolism and nutrient digestion

description: Additional file 6:Â Table S2. Proteomics Enrichment. A comparison of the number of proteins identified during different protein extraction methods is shown. As the pellet sample is thought to be enriched in transmembrane proteins, comparisons were made between proteins with predicted transmembrane domains and others. However, no difference in membrane proteins was found among the two techniques.
DOI: 10.6084/m9.figshare.11821056.v1
title: Additional file 8 of A transcriptomic and proteomic atlas of expression in the Nezara viridula (Heteroptera: Pentatomidae) midgut suggests the compartmentalization of xenobiotic metabolism and nutrient digestion

description: Additional file 8:Â Table S4. Full proteome. A full table of all unigenes identified in this study with an indication of whether the unigene was detected in the proteome of a given tissue. Corresponding sequences for transcripts can be found in the bioproject PRJNA557118.
DOI: 10.6084/m9.figshare.11821053.v1
title: Additional file 7 of A transcriptomic and proteomic atlas of expression in the Nezara viridula (Heteroptera: Pentatomidae) midgut suggests the compartmentalization of xenobiotic metabolism and nutrient digestion

description: Additional file 7:Â Table S3. Transcript TPMs. A full table of all unigenes identified in this study with their predicted expression (average TPM values across 4 samples) are shown for each midgut compartment along with an annotation based on Uniref50. Corresponding sequences for transcripts can be found in the bioproject PRJNA557118.
DOI: 10.6084/m9.figshare.11821041
title: Additional file 5 of A transcriptomic and proteomic atlas of expression in the Nezara viridula (Heteroptera: Pentatomidae) midgut suggests the compartmentalization of xenobiotic metabolism and nutrient digestion

description: Additional file 5: Table S1. Transporter nomenclature comparisons.Â An equivalency table is shown indicating the nomenclature of transporter families and their proposed substrates. Transporters are generally named according to their SLC family, Transporter Classification Database code (e.g. 2.A.22) or their common name, which indicates their general function.
DOI: 10.6084/m9.figshare.11821050.v1
title: Additional file 6 of A transcriptomic and proteomic atlas of expression in the Nezara viridula (Heteroptera: Pentatomidae) midgut suggests the compartmentalization of xenobiotic metabolism and nutrient digestion

description: Additional file 6:Â Table S2. Proteomics Enrichment. A comparison of the number of proteins identified during different protein extraction methods is shown. As the pellet sample is thought to be enriched in transmembrane proteins, comparisons were made between proteins with predicted transmembrane domains and others. However, no difference in membrane proteins was found among the two techniques.
DOI: 10.6084/m9.figshare.11821041.v1
title: Additional file 5 of A transcriptomic and proteomic atlas of expression in the Nezara viridula (Heteroptera: Pentatomidae) midgut suggests the compartmentalization of xenobiotic metabolism and nutrient digestion

description: Additional file 5: Table S1. Transporter nomenclature comparisons.Â An equivalency table is shown indicating the nomenclature of transporter families and their proposed substrates. Transporters are generally named according to their SLC family, Transporter Classification Database code (e.g. 2.A.22) or their common name, which indicates their general function.
DOI: 10.6084/m9.figshare.11821017
title: Additional file 1 of A transcriptomic and proteomic atlas of expression in the Nezara viridula (Heteroptera: Pentatomidae) midgut suggests the compartmentalization of xenobiotic metabolism and nutrient digestion

description: Additional file 1: Figure S1. Comparison of transcript expression with protein detection. A boxplot comparing the output of the RNA-seq analysis with the proteomic analysis is shown. All unigenes were categorized as either “Present” or “Absent” in the proteome (x axis) and plotted according to their transcription level (y axis) in terms of log (base 2) transformed TPM value. These data suggest that genes detected in the proteome had generally higher transcript expression compared to those proteins that were not detected.