cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.5281/zenodo.6033699
title: Dataset related to article "Charlson comorbidity index and G8 in older old adult(≥80 years) hepatocellular carcinoma patients treated with stereotactic body radiotherapy "

description: This record contains raw data related to article “Charlson comorbidity index and G8 in older old adult(≥80 years) hepatocellular carcinoma patients treated with stereotactic body radiotherapy" <strong>Introduction: </strong> Hepatocellular Carcinoma (HCC) is characterized, in Western countries, by higher incidence and mortality rates in the older adult population. In frail patients, limited therapeutic resources are available due to limited expected benefit concerning the risk of treatment-related toxicity. The aim of our study is to evaluate the role of Stereotactic Body Radiotherapy (SBRT) in the clinical management of older old adults (age ≥ 80 years) HCC patients and to identify predictors of efficacy and toxicity. <strong>Material and methods: </strong> Clinical and treatment-related data of older old adults HCC patients treated with SBRT at our institution were retrospectively reviewed. Statistical analysis was carried out to identify variables correlated with impaired outcome and toxicity. <strong>Results: </strong> Forty-two patients were included, accounting for 63 treated tumors. Median age was 85 (range 80-91) years. Median Charlson Comorbidity Index (CCI) and G8 scores were 10 (range 7-16) and 11 (range 8-14), respectively. SBRT was administered to a median BED10 of 103 Gy10. Median follow-up interval was 11 (range 3-40) months. Two years Local Control (LC), Progression-Free Survival (PFS), and Overall Survival (OS) were 93%, 31%, and 43%, respectively. Acute toxicity occurred in 28% (n = 13) of treatments. A G8 score &gt; 10 was associated with improved survival (p = 0.045), while a CCI ≥10 was correlated with increased acute toxicity (p = 0.021). <strong>Conclusions: </strong> SBRT is a safe and effective option in older old adults HCC patients. A comprehensive geriatric assessment (CGA) is advised before treatment decisions to select optimal candidates for SBRT.
DOI: 10.5281/zenodo.6033698
title: Dataset related to article "Charlson comorbidity index and G8 in older old adult(≥80 years) hepatocellular carcinoma patients treated with stereotactic body radiotherapy "

description: This record contains raw data related to article “Charlson comorbidity index and G8 in older old adult(≥80 years) hepatocellular carcinoma patients treated with stereotactic body radiotherapy" <strong>Introduction: </strong> Hepatocellular Carcinoma (HCC) is characterized, in Western countries, by higher incidence and mortality rates in the older adult population. In frail patients, limited therapeutic resources are available due to limited expected benefit concerning the risk of treatment-related toxicity. The aim of our study is to evaluate the role of Stereotactic Body Radiotherapy (SBRT) in the clinical management of older old adults (age ≥ 80 years) HCC patients and to identify predictors of efficacy and toxicity. <strong>Material and methods: </strong> Clinical and treatment-related data of older old adults HCC patients treated with SBRT at our institution were retrospectively reviewed. Statistical analysis was carried out to identify variables correlated with impaired outcome and toxicity. <strong>Results: </strong> Forty-two patients were included, accounting for 63 treated tumors. Median age was 85 (range 80-91) years. Median Charlson Comorbidity Index (CCI) and G8 scores were 10 (range 7-16) and 11 (range 8-14), respectively. SBRT was administered to a median BED10 of 103 Gy10. Median follow-up interval was 11 (range 3-40) months. Two years Local Control (LC), Progression-Free Survival (PFS), and Overall Survival (OS) were 93%, 31%, and 43%, respectively. Acute toxicity occurred in 28% (n = 13) of treatments. A G8 score &gt; 10 was associated with improved survival (p = 0.045), while a CCI ≥10 was correlated with increased acute toxicity (p = 0.021). <strong>Conclusions: </strong> SBRT is a safe and effective option in older old adults HCC patients. A comprehensive geriatric assessment (CGA) is advised before treatment decisions to select optimal candidates for SBRT.
DOI: 10.48370/ofd/dxeyus
title: Chalciporus piperatus (Bull.: Fr.) Bat., 3028

description: Fungarium Macromycetes
DOI: 10.17608/k6.auckland.19152809
title: Gait Plantar Loading

description: This dataset includes the ground reaction force, peak and mean plantar pressures, and center of pressure trajectories during gait.<br>
DOI: 10.5281/zenodo.6033757
title: Live capture and handling of Taiwanese leopard cats_Data

description: This data set forms the basis of a scientific open access publication in Wildlife Biology: <strong>van der Meer E, Dullemont H, Chen WL, Chang AM, Chen CC, Pei KJC, Lai YC (2022) Live capture and handling of Taiwanese leopard cats (<em>Prionailurus bengalensis</em>): an evaluation of trap designs and capture protocol. Wildlife Biology.</strong> It contains data on trap characteristics, leopard cat visits, domestic dog visits and bycatch for various trap designs used for the live trapping of leopard cats in Taiwan. It also includes data on leopard cat movement in the first six days after trapping and handling, based on triangulation of the signal from the VHF collars of the study animals.
DOI: 10.5281/zenodo.6033756
title: Live capture and handling of Taiwanese leopard cats_Data

description: This data set forms the basis of a scientific open access publication in Wildlife Biology: <strong>van der Meer E, Dullemont H, Chen WL, Chang AM, Chen CC, Pei KJC, Lai YC (2022) Live capture and handling of Taiwanese leopard cats (<em>Prionailurus bengalensis</em>): an evaluation of trap designs and capture protocol. Wildlife Biology.</strong> It contains data on trap characteristics, leopard cat visits, domestic dog visits and bycatch for various trap designs used for the live trapping of leopard cats in Taiwan. It also includes data on leopard cat movement in the first six days after trapping and handling, based on triangulation of the signal from the VHF collars of the study animals.
DOI: 10.17632/6h37h7357n.1
title: Hepcidin levels predict COVID-19 severity and mortality in a cohort of hospitalized italian patients

description: Several risk factors for SARS-COV2 infection are well established, including advanced age, male gender, strong inflammatory response, neutropenia and lymphopenia, and more recently hypoferremia. Hepcidin, the liver peptide hormone whose role is to regulate iron concentration in the blood stream, is at the crossroad between iron metabolism and inflammation, being positively regulated by iron itself and proinflammatory cytokines. However, its role as potential biomarker of COVID-19 severity has only partially been explored. In this paper, we analyzed plasma hepcidin levels in a well-characterized cohort of 111 Italian COVID-19 patients admitted at San Raffaele University Hospital, in Milan. In this cohort, all patients are hypoferremic and hepcidin levels do not correlate with iron, instead hepcidin expression is mainly driven by inflammation and correlates with markers of lung function. Although plasma iron levels remain equally low in all groups examined, both in hypoxemic and in non-surviving patients hepcidin levels are higher than in the corresponding control groups likely due to the strong inflammation. More interestingly, in critical patients in intensive care unit hepcidin is an independent predictor of mortality, at difference with parameters of inflammation. Overall our data add hepcidin as a marker of morbidity and outcome, especially in severely compromised patients. 
doi: 10.1002/ajh.26027
DOI: 10.48370/ofd/zmwswg
title: Cheilymenia fimicola (De Not. Bagl.) Dennis, 3657

description: Fungarium Macromycetes
DOI: 10.5517/ccdc.csd.cc27186s
title: CCDC 2056794: Experimental Crystal Structure Determination

description: Related Article: Ziyan Wu, Jingjing Wang, Feng Li, Hanhui Zhai, Qiuyue Ding, Dongyun Han, Zubin Cao|2022|Tetrahedron Lett.|91|153642|doi:10.1016/j.tetlet.2022.153642
DOI: 10.5281/zenodo.6033784
title: Dataset related to article " Behavioural and cognitive phenotypes of patients with amyotrophic lateral sclerosis carrying SOD1 mutations" (manuscript submitted)

description: Clinical and neuropsychological anonymized data of patients involved in the study presented in the submitted article mentioned at title
DOI: 10.5281/zenodo.6033783
title: Dataset related to article " Behavioural and cognitive phenotypes of patients with amyotrophic lateral sclerosis carrying SOD1 mutations" (manuscript submitted)

description: Clinical and neuropsychological anonymized data of patients involved in the study presented in the submitted article mentioned at title
DOI: 10.48370/ofd/aedrgy
title: Cheilymenia stercorea (F.H.Wigg.) Boud., 1719

description: Fungarium Macromycetes
DOI: 10.25919/7g9r-ab16
title: RV Investigator Voyage IN2019_V01 End of Voyage (EOV) Archive

description: This record describes the End of Voyage (EOV) archive from the Marine National Facility (MNF) RV Investigator research voyage IN2019_V01. The voyage is known as "ENRICH (Euphausiids and Nutrient Recycling in Cetacean Hotspots)", with a voyage proposal titled "The availability of Antarctic krill to large predators and their role in biogeochemical recycling in the Southern Ocean." The voyage took place from Hobart (TAS) to Hobart between January 19 and March 5, 2019 (AEST). For further information refer to the Voyage documentation links below. Instruments used and data collected include: Regular measurements: Acoustic Doppler Current Profiler (ADCP; 75, 150 KHz ), Lowered ADCP (LADCP), Fisheries echosounder (EK60), Multibeam Echosounder (EM710, EM122), Sub-bottom Profiler (SBP120), Gravimeter, GPS Positioning System, Doppler Velocity Log, Temperature, Humidity, Pressure, Wind and Rain sensors, Photosynthetically Active Radiation (PAR) sensor, Precision Infrared Radiometer (PIR), Precision Spectral Pyranometer (PSP), Nephelometer, pCO2, Condensation Particle Counters (CPC), Cloud Condensation Nuclei counter (CCN), Scanning Mobility Particle Sizers (SMPS), Multiangle Absorption Photometer (MAAP), Starboard and Portside Radiometers, Radon and Ozone sensors, Weather Radar, Greenhouse Gas Analysers (Picarro), Infrared Sea Surface Temperature Autonomous Radiometer (ISAR), Fluorometer, Oxygen optode, Thermosalinographs (TSG), CTD, Hydrochemistry, Expendable Bathythermographs (XBTs). Voyage-specific measurements: Fisheries echosounder (ME70, SH90), Continuous Plankton Recorder (CPR), Fluorescence Induction and Relaxation System (FIRe), ITI Trawl net, Trace Metals, ECO Triplet, Ultra Short BaseLine Underwater Positioning System (USBL), Bird Observations, Whale Observations. The archive for the IN2019_V01 EOV raw data is curated by the CSIRO NCMI Information and Data Centre (IDC) in Hobart, with a permanent archive at the CSIRO Data Access Portal (DAP, https://data.csiro.au/dap/), providing access to participants and processors of the data collected in the voyage. All voyage documentation is available electronically to MNF support via the local network. Access to voyage documentation for non-CSIRO participants can be made via NCMI_DataLibrarians@csiro.au.
DOI: 10.25403/upresearchdata.19145783.v1
title: Angiogenic, apoptotic and autophagic profiling of chronic myeloid leukaemia patients’ platelets ex vivo before and after treatment with Imatinib

description: The data presented here was to determine the angiogenic, apoptotic, and autophagic profiles of chronic myeloid leukaemia patients <i>ex vivo</i> on platelets before and after treatment with Imatinib. Platelet counts, viability and activation were determined by human cluster of differentiation (CD) 41 and -62 markers. The possible occurrence of apoptosis and autophagy was measured by means of flow cytometry and western blot analysis via Annexin V-fluorescein isothiocyanate (FITC), caspase 3, autophagy related gene 5 (Atg5) and light chain I and II (LC3) markers. Angiogenesis expression was determined through vascular endothelial growth factor (VEGF) and transforming growth factor β (TGFβ) markers.
DOI: 10.25403/upresearchdata.19145783
title: Angiogenic, apoptotic and autophagic profiling of chronic myeloid leukaemia patients’ platelets ex vivo before and after treatment with Imatinib

description: The data presented here was to determine the angiogenic, apoptotic, and autophagic profiles of chronic myeloid leukaemia patients <i>ex vivo</i> on platelets before and after treatment with Imatinib. Platelet counts, viability and activation were determined by human cluster of differentiation (CD) 41 and -62 markers. The possible occurrence of apoptosis and autophagy was measured by means of flow cytometry and western blot analysis via Annexin V-fluorescein isothiocyanate (FITC), caspase 3, autophagy related gene 5 (Atg5) and light chain I and II (LC3) markers. Angiogenesis expression was determined through vascular endothelial growth factor (VEGF) and transforming growth factor β (TGFβ) markers.
DOI: 10.6084/m9.figshare.18133796
title: Supplementary Material for: Developmental iron deficiency dysregulates TET activity and DNA hydroxymethylation in the rat hippocampus and cerebellum

description: Iron deficiency (ID) during neurodevelopment is associated with lasting cognitive and socioemotional deficits, and increased risk for neuropsychiatric disease throughout the lifespan. These neurophenotypical changes are underlain by gene dysregulation in the brain that outlasts the period of ID; however, the mechanisms by which ID establishes and maintains gene expression changes are incompletely understood. The epigenetic modification 5-hydroxymethylcytosine (5hmC), or DNA hydroxymethylation, is one candidate mechanism because of its dependence on iron-containing TET enzymes. The aim of the present study was to determine the effect of fetal-neonatal ID on regional brain TET activity, Tet expression, and 5hmC in the developing rat hippocampus and cerebellum, and to determine whether changes are reversible with dietary iron treatment. Timed pregnant Sprague-Dawley rats were fed iron deficient diet (ID; 4 mg/kg Fe) from gestational day (G)2 to generate iron deficient anemic (IDA) offspring. Control dams were fed iron sufficient diet (IS; 200 mg/kg Fe). At postnatal day (P)7, a subset of ID-fed litters was randomized to IS diet, generating treated IDA (TIDA) offspring. At P15, hippocampus and cerebellum were isolated for subsequent analysis. TET activity was quantified by ELISA from nuclear proteins. Expression of Tet1, Tet2, and Tet3 was quantified by qPCR from total RNA. Global %5hmC was quantified by ELISA from genomic DNA. ID increased DNA hydroxymethylation (p=0.0105), with a corresponding increase in TET activity (p&lt;0.0001) and Tet3 expression (p&lt;0.0001) in the P15 hippocampus. In contrast, ID reduced TET activity (p=0.0016) in the P15 cerebellum, with minimal effect on DNA hydroxymethylation. Neonatal dietary iron treatment resulted in partial normalization of these changes in both brain regions. These results demonstrate that the TET/DNA hydroxymethylation system is disrupted by developmental ID in a brain region-specific manner. Differential regional disruption of this epigenetic system may contribute to the lasting neural circuit dysfunction and neurobehavioral dysfunction associated with developmental ID.
DOI: 10.6084/m9.figshare.18133796.v1
title: Supplementary Material for: Developmental iron deficiency dysregulates TET activity and DNA hydroxymethylation in the rat hippocampus and cerebellum

description: Iron deficiency (ID) during neurodevelopment is associated with lasting cognitive and socioemotional deficits, and increased risk for neuropsychiatric disease throughout the lifespan. These neurophenotypical changes are underlain by gene dysregulation in the brain that outlasts the period of ID; however, the mechanisms by which ID establishes and maintains gene expression changes are incompletely understood. The epigenetic modification 5-hydroxymethylcytosine (5hmC), or DNA hydroxymethylation, is one candidate mechanism because of its dependence on iron-containing TET enzymes. The aim of the present study was to determine the effect of fetal-neonatal ID on regional brain TET activity, Tet expression, and 5hmC in the developing rat hippocampus and cerebellum, and to determine whether changes are reversible with dietary iron treatment. Timed pregnant Sprague-Dawley rats were fed iron deficient diet (ID; 4 mg/kg Fe) from gestational day (G)2 to generate iron deficient anemic (IDA) offspring. Control dams were fed iron sufficient diet (IS; 200 mg/kg Fe). At postnatal day (P)7, a subset of ID-fed litters was randomized to IS diet, generating treated IDA (TIDA) offspring. At P15, hippocampus and cerebellum were isolated for subsequent analysis. TET activity was quantified by ELISA from nuclear proteins. Expression of Tet1, Tet2, and Tet3 was quantified by qPCR from total RNA. Global %5hmC was quantified by ELISA from genomic DNA. ID increased DNA hydroxymethylation (p=0.0105), with a corresponding increase in TET activity (p&lt;0.0001) and Tet3 expression (p&lt;0.0001) in the P15 hippocampus. In contrast, ID reduced TET activity (p=0.0016) in the P15 cerebellum, with minimal effect on DNA hydroxymethylation. Neonatal dietary iron treatment resulted in partial normalization of these changes in both brain regions. These results demonstrate that the TET/DNA hydroxymethylation system is disrupted by developmental ID in a brain region-specific manner. Differential regional disruption of this epigenetic system may contribute to the lasting neural circuit dysfunction and neurobehavioral dysfunction associated with developmental ID.
DOI: 10.5525/gla.researchdata.1247
title: Simulated Assessment of light transport through ischaemic skin flaps

description: The dataset contains all the optical models and the corresponding fluence maps generated for reproducing the scenarios detailed in the publication. Additionally, the optical properties calculated and the final results are also provided in the folders.
DOI: 10.17632/mspt9hx4sy.1
title: 10.1021/acs.jmedchem.1c00533: Halting the Spread of Herpes Simplex Virus-1: The Discovery of an Effective Dual αvβ6/αvβ8 Integrin Ligand

description: 1. Data_supplementary_tableS2.csv  contains the 1H Amide chemical shifts of the molecule 6 as function of temperature. These values have been used to calculate the corresponding  temperature factors reported in  Supplementary Table S3 in
10.1021/acs.jmedchem.1c00533
2. Data_supplementary_tableS3.csv  thsi table continas the data (NOE intensities) of molecule 6 used to generate the distance restraints displayd in Supplementary table S3 in 10.1021/acs.jmedchem.1c00533
DOI: 10.17632/62r6g586b7.1
title: Delay in Pancreatic Endoscopic Ultrasound During the COVID-19 Pandemic in a Pancreas/Tertiary Referral Center.

description: In our tertiary referral Pancreas Center, we observed a reduction in the number of pancreatic endoscopic ultrasound (EUSP) procedures, mostly performed for neoplastic and pre-neoplastic reasons, during lockdown. We compared the period of major spreading of Covid-19 Infection in Italy, between February 1st and April 30th, 2020, with the same period in 2019.
DOI: 10.48370/ofd/fpab7b
title: Chlorociboria aeruginosa (Pers.: Fr.) Seaver ex C. S.Ramamuthri, Korf L.R.Batra, 1586

description: Fungarium Macromycetes
DOI: 10.17632/8wvxff49g8.1
title: Use of edge-to-edge percutaneous mitral valve repair for severe mitral regurgitation in cardiogenic shock: A multicenter observational experience (MITRA-SHOCK study)

description: DOI: 10.1002/ccd.29683
Patients with cardiogenic shock and concomitant severe mitral regurgitation have high mortality rates. This study evaluated the procedural safety and efficacy at short and mid-term of edge-to-edge percutaneous mitral valve repair (PMVR) in this setting. We found that edge-to-edge PMVR had an acceptable complication rate and procedural success was a predictor of both 30-day and 6-month survival. We concluded that edge-to-edge PMVR is a safe and effective procedure in patients with severe mitral regurgitation complicating cardiogenic shock and could be considered a bailout option in this setting.
DOI: 10.17632/gzvvg9khz7.1
title: Right ventricular systolic function in severe tricuspid regurgitation: prognostic relevance of longitudinal strain

description: doi: 10.1093/ehjci/jeab030
The aim of this study is to analyse the prognostic implications of right ventricular (RV) dysfunction as detected by strain analysis in patients with severe tricuspid regurgitation (TR). The evaluation of RV systolic function in presence of severe TR is of paramount importance for operative risk stratification; however, it remains challenging, as conventional echocardiographic indexes usually lead to overestimation. The study population included 250 patietns with severe TR. Different ranges of RVFWLS have different implications in patients with severe TR, allowing to identify a preclinical and a clinical window, with correlations to RVHF and survival.
DOI: 10.17632/zj3hc94rfx.1
title: Subclinical myocardial dysfunction in patients recovered from COVID-19

description: doi: 10.1111/echo.15215
Myocardial injury (MI) can be detected during the acute phase of Coronavirus disease 19 (COVID-19) and is associated with a dismal prognosis.  Recent imaging studies described the persistence of cardiac abnormalities after the recovery. The aim of the study was to investigate the spectrum of cardiac abnormalities at mid-term follow-up in patients recovered from COVID-19 using clinical assessment, laboratory tests and imaging evaluation with comprehensive echocardiography.1 The study included 123 patients divided into two groups according to the presence of MI during hospitalization. At 3 months follow-up patients with prior MI showed lower values of global longitudinale strain, higher frequency of8 impaired diastolic funcion and higher values of pulmonary pressure. Echocardiography with speckle-tracking analysis may be a usefull tool to identify subclinical myocardial dysfunction in patients recovered from COVID-19.
DOI: 10.48370/ofd/sggbr9
title: Chlorociboria aeruginosa (Pers.: Fr.) Seaver ex C. S.Ramamuthri, Korf L.R.Batra, 2889

description: Fungarium Macromycetes
DOI: 10.6084/m9.figshare.19152911.v1
title: Risk of bias assessment

description: Risk of bias assessment
DOI: 10.6084/m9.figshare.19152911
title: Risk of bias assessment

description: Risk of bias assessment
DOI: 10.5286/isis.e.rb2210128
title: Elucidating the structure of DNA linkers tethered to electrode surfaces

description: Recent results have pointed to an unexpected role of DNA as a possible agent for electron transfer. This could be crucial in understanding the purpose of DNA in bacterial biofilms, in which electron transfer from the cells to external acceptors (such as an electrode surface) is essential for the wellbeing and survival of the biofilm. However, the ability of DNA to conduct is thought to be strongly linked to its structure, and it is unclear how this may be affected by external conditions such as applied potential, or the presence and binding of small redox molecules. This proposal aims to study tethered DNA layers at electrode surfaces to model these more complex systems. Neutron reflectometry will allow us an unprecedented opportunity to monitor the structure and how it changes in situ during the electron-transfer processes of interest.