cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.8227091.v1
title: Bank workers’ mental strain: building confrontation strategies

description: Abstract This report aims to present and discuss the basis, development and results of a support group constituted with sick bank workers. The activity was carried out by the Núcleo de Ação em Saúde do Trabalhador - NAST (Workers’ Health Action Center) in partnership with the Bank Workers’ Union of Limeira, state of São Paulo, Brazil. Starting from the workers’ professional life, the objective was to query the current labor organization in this sector. The group held eight meetings of approximately two hours each at the union headquarters in Limeira. During the meetings, workers reported adverse work situations that were determinant in their health-disease process. Most of the workers’ complaints were related to the mental strain caused by pressure to achieve oversized goals, and by the lack of recognition by the institution managers and users. The support group proved to be a powerful confrontation device and an important tool in providing a voice space for workers to articulate the construction of individual and collective strategies for health promotion in the workplace.
DOI: 10.6084/m9.figshare.8227076
title: Secondary lymphedema of limbs and chikungunya fever

description: Abstract Certain systemic viral infections can be related to development of vascular complications, such as deep venous thrombosis and lymphedema of lower and upper limbs. These links have been well-established in patients with human immunodeficiency virus (HIV), hepatitis C, or influenza. Recently introduced into the American continent (2013), chikungunya virus is an arbovirus transmitted by mosquitoes of the Aedes genus and is the etiologic agent of chikungunya fever (CF), but its relationship to these vascular complications has not yet been consolidated. However, the CF outbreak that occurred during 2015 and 2016 resulted in the first cases described in the medical literature of acute and chronic vascular complications secondary to infection by this arbovirus. In this report, we describe the case of a patient who developed lymphedema of upper and lower limbs after an episode of CF.
DOI: 10.6084/m9.figshare.8227085.v1
title: PROXIMAL HUMERUS FRACTURE WITH LOCKING PLATE: FUNCTIONAL AND RADIOGRAPHIC RESULTS

description: ABSTRACT Objective: To correlate the functional outcome and radiographic indices of proximal humerus fractures treated with locking plate. Methods: Seventy patients with proximal humerus fractures treated with locking plate, with mean follow-up of 30 months. These patients were analyzed for the score of the University of California, Los Angeles (UCLA) for the operated shoulder, range of motion measurements and radiography of both shoulders. After that, a graphical correlation was established between the radiographic measurements and the functional outcomes. Results: 78% good and excellent results according to the UCLA score, with mean130° elevation; 45° lateral rotation; and thumb-T10 medial rotation. The type of fracture according to the Neer classification and age had a significant correlation with the range of motion. An association was found between the lowest mean elevation and the UCLA score when the neck-shaft angle variation in the antero-posterior plane was greater than 15° varus (p &lt;0.001). Conclusion: The variation of the neck-shaft angle measurement in the anteroposterior plane showed significant correlation with the range of motion and can be one of the predictors of functional results in proximal humerus fractures treated with locking plate. Level of evidence III, Retrospective Study.
DOI: 10.6084/m9.figshare.8227082.v1
title: SLAP IV IN OVERHEAD SPORTS PRACTICE

description: ABSTRACT Superior labral tear from anterior to posterior (SLAP) is the most common disease in overhead sports practice. Objective: to evaluate the functional outcome after tenodesis of long head biceps tendon (LHBT) in high-performance patients with isolated SLAP lesion refractory to conservative treatment. Methods: Patients underwent the same open repair procedure, using an interference screw. Results: Both patients presented good clinical results and returned to the sport with performance similar to that prior to the injury. Conclusion: The results favor the surgical treatment of these athletes with SLAP IV. Level of Evidence IV, Série de Casos.
DOI: 10.6084/m9.figshare.8227073
title: Clinical research challenges in rare genetic diseases in Brazil

description: Abstract Rare diseases are defined as conditions with a prevalence of no more than 6.5 per 10,000 people. Although each rare disease individually affects a small number of people, collectively, the 6,000 to 8,000 rare conditions (80% of them with genetic cause) affect around 8% of the world’s population. Research about the natural history and underlying pathophysiological mechanisms of rare diseases, as well as clinical trials with new drugs, are important and necessary to develop new strategies for the treatment of these conditions. This report describes the experience of a clinical research group working with rare diseases in a reference center for lysosomal diseases in Brazil (Medical Genetics Service, Hospital de Clínicas de Porto Alegre). The activities of this research group enabled its participation in several international multicenter clinical research protocols related to the natural history or therapy development for rare genetic diseases. This participation has allowed the development of personal skills and institutional facilities for clinical research. The clinical research developed in our center has raised the quality of the medical assistance provided to non-clinical research patients in addition to enabling early access to new therapies to many patients with orphan conditions.
DOI: 10.6084/m9.figshare.8227076.v1
title: Secondary lymphedema of limbs and chikungunya fever

description: Abstract Certain systemic viral infections can be related to development of vascular complications, such as deep venous thrombosis and lymphedema of lower and upper limbs. These links have been well-established in patients with human immunodeficiency virus (HIV), hepatitis C, or influenza. Recently introduced into the American continent (2013), chikungunya virus is an arbovirus transmitted by mosquitoes of the Aedes genus and is the etiologic agent of chikungunya fever (CF), but its relationship to these vascular complications has not yet been consolidated. However, the CF outbreak that occurred during 2015 and 2016 resulted in the first cases described in the medical literature of acute and chronic vascular complications secondary to infection by this arbovirus. In this report, we describe the case of a patient who developed lymphedema of upper and lower limbs after an episode of CF.
DOI: 10.6084/m9.figshare.8227070
title: The natural history of pregnancies with prenatal diagnosis of Trisomy 18 or Trisomy 13: Retrospective cases of a 23-year experience in a Brazilian public hospital

description: Abstract Trisomy 18 (T18) and trisomy 13 (T13) are polymalformative syndromes associated with a high rate of spontaneous abortions, intrauterine death, and short postnatal life. This study describes the overall outcome in a country where the therapeutic interruption of pregnancy is not available. The medical records of women with prenatal diagnosis of full trisomy of T13 or T18 between October 1994 and October 2017 were analyzed in order to describe their natural outcomes. Thirteen cases of T13 and 29 cases of T18 were included. The miscarriage rate was 9% for T18 and no cases for T13. Intrauterine fetal death occurred in 46% and 52% of cases for T13 and T18, respectively. The rate of live births for T13 was 54%, and the median survival was one day (95% CI -33.55 - 90.40) and 71% died in the first 24 hours of life. The rate of live births for T18 was 37% and the median survival was two days (95% CI -1.89 - 13.17); 90% of the affected babies died within first week of life. For the affected babies reaching the first year of life and for those who lived longer, multiple invasive and expensive procedures were required, without success in prolonging life beyond 180 days. This large series provides information for professionals and women regarding the natural histories of T13 and T18. Results of this study are consistent with those referenced in the literature, emphasizing the need of structured protocols and guidelines aiming early T13 and T18 diagnosis, prenatal care, gestation/parents follow-up, and counseling processes. For those couples with earlier diagnosis, a better follow-up and counseling during the prenatal care lead to the option for a support or palliative management of the newborn. Finally, when the counseling process is appropriate, it becomes easier to take decisions respecting the parent’s autonomy and to look for better outcomes for both, the mother and the fetus.
DOI: 10.6084/m9.figshare.8227067
title: Performance of the Gail and Tyrer-Cuzick breast cancer risk assessment models in women screened in a primary care setting with the FHS-7 questionnaire

description: Abstract Breast cancer (BC) risk assessment models base their estimations on different aspects of a woman’s personal and familial history. The Gail and Tyrer–Cuzick models are the most commonly used, and BC risks assigned by them vary considerably especially concerning familial history. In this study, our aim was to compare the Gail and Tyrer-Cuzick models after initial screening for familial history of cancer in primary care using the FHS-7 questionnaire. We compared 846 unrelated women with at least one positive answer to any of the seven FHS-7 questions (positive group) and 892 unrelated women that answered negatively (negative group). Concordance between BC risk estimates was compared by Bland-Altman graphics. Mean BC risk estimates were higher using the Tyrer-Cuzick Model in women from the positive group, while women from the negative group had higher BC risk estimates using the Gail model. With increasing estimates, discordance also increased, mainly in the FHS-7 positive group. Our results show that in women with a familial history of cancer, the Gail model underestimates risk and the Tyrer-Cuzick seems to be more appropriate. FHS-7 can be a useful tool for the identification of women with higher breast cancer risks in the primary care setting.
DOI: 10.6084/m9.figshare.8227070.v1
title: The natural history of pregnancies with prenatal diagnosis of Trisomy 18 or Trisomy 13: Retrospective cases of a 23-year experience in a Brazilian public hospital

description: Abstract Trisomy 18 (T18) and trisomy 13 (T13) are polymalformative syndromes associated with a high rate of spontaneous abortions, intrauterine death, and short postnatal life. This study describes the overall outcome in a country where the therapeutic interruption of pregnancy is not available. The medical records of women with prenatal diagnosis of full trisomy of T13 or T18 between October 1994 and October 2017 were analyzed in order to describe their natural outcomes. Thirteen cases of T13 and 29 cases of T18 were included. The miscarriage rate was 9% for T18 and no cases for T13. Intrauterine fetal death occurred in 46% and 52% of cases for T13 and T18, respectively. The rate of live births for T13 was 54%, and the median survival was one day (95% CI -33.55 - 90.40) and 71% died in the first 24 hours of life. The rate of live births for T18 was 37% and the median survival was two days (95% CI -1.89 - 13.17); 90% of the affected babies died within first week of life. For the affected babies reaching the first year of life and for those who lived longer, multiple invasive and expensive procedures were required, without success in prolonging life beyond 180 days. This large series provides information for professionals and women regarding the natural histories of T13 and T18. Results of this study are consistent with those referenced in the literature, emphasizing the need of structured protocols and guidelines aiming early T13 and T18 diagnosis, prenatal care, gestation/parents follow-up, and counseling processes. For those couples with earlier diagnosis, a better follow-up and counseling during the prenatal care lead to the option for a support or palliative management of the newborn. Finally, when the counseling process is appropriate, it becomes easier to take decisions respecting the parent’s autonomy and to look for better outcomes for both, the mother and the fetus.
DOI: 10.6084/m9.figshare.8227061
title: Multifractal Properties of Daily Air Temperature Records Over Northeast, Brazil

description: Abstract The investigation of the dynamics of climatic variables provides important information about their spatio-temporal variability. Understanding these processes is fundamental for the development of climate models that serve as a basis for analysis of future scenarios and prediction of climate change. In this work, we analyze multifractal properties of daily air temperature series in Northeast Brazil recorded during the period 1990 to 2015, in 94 meteorological stations distributed over the region. We applied the Multifractal Detrended Fluctuation Analysis (MF-DFA) method that was developed to quantify long-range correlations in multifractal time series. The results show that the process that generates the variability of the air temperature follows the multifractal dynamics, with greater influence of the seasonal component. A persistent auto-correlation was observed, with stronger persistence in the proximity of the equator. The degree of multifractality indicated by the width of the multifractal spectrum varies according to the climatic classification of the region. The strongest multifractality was observed in the Mata and Agreste Zone. The results indicate that long memory in time series of the daily average air temperature of the Brazilian Northeast should be modeled as a multifractal process and may contribute to the development of more reliable regional climate models.
DOI: 10.6084/m9.figshare.8227073.v1
title: Clinical research challenges in rare genetic diseases in Brazil

description: Abstract Rare diseases are defined as conditions with a prevalence of no more than 6.5 per 10,000 people. Although each rare disease individually affects a small number of people, collectively, the 6,000 to 8,000 rare conditions (80% of them with genetic cause) affect around 8% of the world’s population. Research about the natural history and underlying pathophysiological mechanisms of rare diseases, as well as clinical trials with new drugs, are important and necessary to develop new strategies for the treatment of these conditions. This report describes the experience of a clinical research group working with rare diseases in a reference center for lysosomal diseases in Brazil (Medical Genetics Service, Hospital de Clínicas de Porto Alegre). The activities of this research group enabled its participation in several international multicenter clinical research protocols related to the natural history or therapy development for rare genetic diseases. This participation has allowed the development of personal skills and institutional facilities for clinical research. The clinical research developed in our center has raised the quality of the medical assistance provided to non-clinical research patients in addition to enabling early access to new therapies to many patients with orphan conditions.
DOI: 10.6084/m9.figshare.8227067.v1
title: Performance of the Gail and Tyrer-Cuzick breast cancer risk assessment models in women screened in a primary care setting with the FHS-7 questionnaire

description: Abstract Breast cancer (BC) risk assessment models base their estimations on different aspects of a woman’s personal and familial history. The Gail and Tyrer–Cuzick models are the most commonly used, and BC risks assigned by them vary considerably especially concerning familial history. In this study, our aim was to compare the Gail and Tyrer-Cuzick models after initial screening for familial history of cancer in primary care using the FHS-7 questionnaire. We compared 846 unrelated women with at least one positive answer to any of the seven FHS-7 questions (positive group) and 892 unrelated women that answered negatively (negative group). Concordance between BC risk estimates was compared by Bland-Altman graphics. Mean BC risk estimates were higher using the Tyrer-Cuzick Model in women from the positive group, while women from the negative group had higher BC risk estimates using the Gail model. With increasing estimates, discordance also increased, mainly in the FHS-7 positive group. Our results show that in women with a familial history of cancer, the Gail model underestimates risk and the Tyrer-Cuzick seems to be more appropriate. FHS-7 can be a useful tool for the identification of women with higher breast cancer risks in the primary care setting.
DOI: 10.6084/m9.figshare.8227049
title: Long Term Monitoring and Climatology of Stratospheric Fields when the Occurrence of Influence of the Antarctic Ozone Hole Over South of Brazil Events

description: Abstract The long-term monitoring of Influence of the Antarctic Ozone Hole over South of Brazil events was carried out for the period of 35 years between 1979 and 2013 and the climatology and anomalies of the stratospheric fields were calculated when this type of phenomenon occurred. For this, the data of the total ozone column (TOC) was obtained by Brewer Spectrophotometers, installed at the Southern Space Observatory - SSO / CRS / INPE - MCTIC (29.4 °S, 53.8 °W, 488, 7 m) and the Total Ozone Mapping Spectrometer (TOMS) and Ozone Monitoring Instrument (OMI) satellite instruments, as well as the reanalysis II of the NCEP / DOE (National Centers for Environmental Prediction / Department of Energy) and retroactive trajectories by HYSPLIT ( HYbrid Single-Particle Lagrangian Integrated Trajectory) model. The methodology used was effective in identifying 62 events with a mean reduction of -9.35 ± 2.93% in the ozone content. In addition, the stratospheric circulation pattern was identified through mean fields and anomalies of potential vorticity, wind and temperature for the occurrence days of the phenomenon, with a wave displacement pattern embedded within a wide cyclonic circulation region, with predominantly southern winds is advected toward the south of Brazil.
DOI: 10.6084/m9.figshare.8227061.v1
title: Multifractal Properties of Daily Air Temperature Records Over Northeast, Brazil

description: Abstract The investigation of the dynamics of climatic variables provides important information about their spatio-temporal variability. Understanding these processes is fundamental for the development of climate models that serve as a basis for analysis of future scenarios and prediction of climate change. In this work, we analyze multifractal properties of daily air temperature series in Northeast Brazil recorded during the period 1990 to 2015, in 94 meteorological stations distributed over the region. We applied the Multifractal Detrended Fluctuation Analysis (MF-DFA) method that was developed to quantify long-range correlations in multifractal time series. The results show that the process that generates the variability of the air temperature follows the multifractal dynamics, with greater influence of the seasonal component. A persistent auto-correlation was observed, with stronger persistence in the proximity of the equator. The degree of multifractality indicated by the width of the multifractal spectrum varies according to the climatic classification of the region. The strongest multifractality was observed in the Mata and Agreste Zone. The results indicate that long memory in time series of the daily average air temperature of the Brazilian Northeast should be modeled as a multifractal process and may contribute to the development of more reliable regional climate models.
DOI: 10.6084/m9.figshare.8227049.v1
title: Long Term Monitoring and Climatology of Stratospheric Fields when the Occurrence of Influence of the Antarctic Ozone Hole Over South of Brazil Events

description: Abstract The long-term monitoring of Influence of the Antarctic Ozone Hole over South of Brazil events was carried out for the period of 35 years between 1979 and 2013 and the climatology and anomalies of the stratospheric fields were calculated when this type of phenomenon occurred. For this, the data of the total ozone column (TOC) was obtained by Brewer Spectrophotometers, installed at the Southern Space Observatory - SSO / CRS / INPE - MCTIC (29.4 °S, 53.8 °W, 488, 7 m) and the Total Ozone Mapping Spectrometer (TOMS) and Ozone Monitoring Instrument (OMI) satellite instruments, as well as the reanalysis II of the NCEP / DOE (National Centers for Environmental Prediction / Department of Energy) and retroactive trajectories by HYSPLIT ( HYbrid Single-Particle Lagrangian Integrated Trajectory) model. The methodology used was effective in identifying 62 events with a mean reduction of -9.35 ± 2.93% in the ozone content. In addition, the stratospheric circulation pattern was identified through mean fields and anomalies of potential vorticity, wind and temperature for the occurrence days of the phenomenon, with a wave displacement pattern embedded within a wide cyclonic circulation region, with predominantly southern winds is advected toward the south of Brazil.
DOI: 10.6084/m9.figshare.8227043
title: Genome-wide identification, characterisation and expression profiling of the ubiquitin-proteasome genes in Biomphalaria glabrata

description: BACKGROUND Biomphalaria glabrata is the major species used for the study of schistosomiasis-related parasite-host relationships, and understanding its gene regulation may aid in this endeavor. The ubiquitin-proteasome system (UPS) performs post-translational regulation in order to maintain cellular protein homeostasis and is related to several mechanisms, including immune responses. OBJECTIVE The aims of this work were to identify and characterise the putative genes and proteins involved in UPS using bioinformatic tools and also their expression on different tissues of B. glabrata. METHODS The putative genes and proteins of UPS in B. glabrata were predicted using BLASTp and as queries reference proteins from model organism. We characterised these putative proteins using PFAM and CDD software describing the conserved domains and active sites. The phylogenetic analysis was performed using ClustalX2 and MEGA5.2. Expression evaluation was performed from 12 snail tissues using RPKM. FINDINGS 119 sequences involved in the UPS in B. glabrata were identified, which 86 have been related to the ubiquitination pathway and 33 to proteasome. In addition, the conserved domains found were associated with the ubiquitin family, UQ_con, HECT, U-box and proteasome. The main active sites were lysine and cysteine residues. Lysines are responsible and the starting point for the formation of polyubiquitin chains, while the cysteine residues of the enzymes are responsible for binding to ubiquitin. The phylogenetic analysis showed an organised distribution between the organisms and the clades of the sequences, corresponding to the tree of life of the animals, for all groups of sequences analysed. The ubiquitin sequence was the only one with a high expression profile found in all libraries, inferring its wide range of performance. MAIN CONCLUSIONS Our results show the presence, conservation and expression profile of the UPS in this mollusk, providing a basis and new knowledge for other studies involving this system. Due to the importance of the UPS and B. glabrata, this work may influence the search for new methodologies for the control of schistosomiasis.