cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.22154585
title: Supplementary Material for: Long-lasting COVID-associated brain fog; a follow-up study

description: Background: We investigated the longevity of COVID-associated brain fog in patients who have survived the COVID-19. Methods: This was a follow-up study of 2,696 adult patients with COVID-19 from our previous study (doi: 10.1002/jmv.27404). We selected every other patient in our database. The follow-up data were collected during a phone call to the participants in January-February 2022 (11 months after the initial study): concentration difficulty and the patient’s self-declared status in their ability to concentrate. Results: In total, 1164 people were included; 35 people (3.0%) had concentration difficulty and 65 individuals (5.6%) had a worsened status in their ability to concentrate and think; 26 people (2.2%) responded yes to both questions and were considered as having long-lasting brain fog. People with long-lasting brain fog were more often admitted to ICUs during the initial hospitalization (23.1% vs. 9.3%; p = 0.032) compared with those without long-lasting brain fog. Conclusion: We may conclude that a minority of the hospitalized patients with COVID-19 may suffer from long-lasting post-COVID brain fog, at least for more than one year after their initial illness. Long-lasting post-COVID brain fog has a significant association with the severity of the initial illness.
DOI: 10.6084/m9.figshare.22270207
title: Supplementary Material for: Accidental ingestion of allergic food at eating-out and home meal replacement by children with food allergy

description: Introduction In Japan, there are no regulations for allergy labeling in eating-out and home replacement meal (HRM). Consequently, patients with food allergy are at risk of accidental ingestion when using these services. It is necessary to understand the current situation of accidental food ingestion at eating-out and HRM to consider related legislation in the future. Methods A web-based survey was conducted from August to September 2021 among patients participating in the survey. The survey included information on the use of eating-out and HRM, frequency of accidental ingestion, medical institution visits and treatment, and reasons for accidental ingestion. Results There were 1141 valid responses, with 8 (5–15) years as the median age of the participants. Moreover, 769 (67.4%) participants had a history of anaphylaxis, 622 (54.5%) experienced accidental ingestion, of which 485 (42.5%) and 348 (30.6%) occurred while eating-out and at HRM, respectively. A total of 71 (14.6%) and 31 (8.9%) participants who had accidental ingestion while eating-out and at HRM, respectively, required hospitalization. Age, milk allergy, and a history of anaphylaxis were risk factors significantly associated with accidental ingestion. The reasons for the accidental ingestions were personal and store-side error for a total of 438 cases of 356 cases, respectively. Discussion/Conclusion It is necessary for both stores and patients to take measures to prevent accidental ingestion in eating-out and HRM. Additionally, the fact that the lack of allergy labeling guidelines for eating-out and HRM, is a major factor in the occurrence of accidental ingestion.
DOI: 10.6084/m9.figshare.22270264
title: Supplementary Material for: Adverse reactions associated with intravenous immunoglobulin administration in the treatment of neurological disorders: A systematic review

description: Intravenous immunoglobulin, which is used to treat multiple neurological conditions, may be associated with serious adverse reactions. The individual neurological disease characteristics associated with adverse reactions, along with strategies to prevent and treat adverse reactions, are uncertain. A systematic review was conducted of the databases PubMed, EMBASE and Cochrane library to summarise studies that report adverse reactions of intravenous immunoglobulin therapy in patients with neurological disease. There were 65 studies included in the review. The reported rates of adverse reactions vary widely but the best evidence suggests rates between 25-34% per patient. Common adverse reactions include headache and laboratory abnormalities. Less common but serious adverse reactions included thromboembolic complications and anaphylaxis. Overall, there is a lack of high-quality comparative data to definitively determine if any specific neurological indications are associated with a higher risk of adverse reactions. However, individual neurological disease characteristics possibly associated with an increased likelihood of adverse reactions include limited mobility (as in certain neuromuscular conditions), paraproteinaemia (as in certain peripheral neuropathies) and cardiomyopathy (as in certain myopathies). There is limited evidence to support the effectiveness of prevention and treatment strategies, which may include modification to dose, reduced infusion rate, and premedication. Further studies regarding methods to prevent and treat IVIg ARs in neurology patients are required.
DOI: 10.6084/m9.figshare.22652080
title: Supplementary Material for: The role of brain integrity in the association between occupational complexity and cognitive performance in subjects with increased risk of dementia

description: Introduction: Mechanisms underlying the positive association between occupational mental demands and late-life cognition are poorly understood. The objective of this study was to assess whether the association between occupational complexity and cognition is related to and moderated by brain integrity in individuals at-risk for dementia. Brain integrity was appraised throughout structural measures (Magnetic Resonance Imaging, MRI) and amyloid accumulation (Pittsburgh Compound B (PiB)-positron emission tomography, PiB-PET). Methods: Participants from the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) neuroimaging sample -MRI (N=126), PiB-PET (N=41)- were included in a post-hoc cross-sectional analysis. Neuroimaging parameters comprised the Alzheimer´s Disease signature cortical thickness (ADS, Freesurfer 5.3), medial temporal atrophy (MTA), and amyloid accumulation (PiB-PET). Cognition was assessed using the Neuropsychological Test Battery. Occupational complexity with data, people, and substantive complexity were classified through the Dictionary of Occupational Titles. Linear regression models included cognition as dependent variable, occupational complexity, measures of brain integrity, and their interaction terms as predictors. Results: Occupational complexity with data and substantive complexity were associated with better cognition (overall cognition, executive function) when adjusting for ADS and MTA (independent association). Significant interaction effects between occupational complexity and brain integrity were also found, indicating that, for some indicators of brain integrity and cognition (e.g., overall cognition, processing speed), the positive association between occupational complexity and cognition occurred only among persons with higher brain integrity (moderated association). Conclusion: Among individuals at-risk for dementia, occupational complexity does not seem to contribute towards resilience against neuropathology. These exploratory findings require validation in larger populations.
DOI: 10.6084/m9.figshare.22954553
title: Supplementary Material for: The recurrent atypical e8a2 BCR::ABL1 transcript with insertion of an inverted 55 base pair ABL1 intron 1b sequence: a detailed molecular analysis

description: Atypical BCR::ABL1 transcripts are found in approximately 2% of cases of chronic myeloid leukemia. It is important to detect them, since affected patients benefit from tyrosine kinase inhibitor therapy, similar to patients with typical BCR::ABL1 variants. In the rare e8a2 atypical BCR::ABL1 transcript two out-of-frame exons are fused, thus, interposed nucleotides are usually found at the fusion site to restore the reading frame. In approximately half of previously reported e8a2 BCR::ABL1 cases an inserted 55 bp sequence homologous to an inverted sequence from ABL1 intron 1b was detected. The generation of this recurrent transcript variant is not obvious. This work describes the molecular analysis of such an e8a2 BCR::ABL1 translocation from a CML patient. The genomic chromosomal breakpoint is identified, and the formation of this transcript variant is theoretically explained. The clinical course of the patient is reported, and recommendations are provided for the molecular analysis of future e8a2 BCR::ABL1 cases.
DOI: 10.6084/m9.figshare.23144624
title: Supplementary Material for: Cx43-Delivered miR-181b Negatively Regulates Sirt1/FOXO3a Signalling Pathway-Mediated Apoptosis on Intestinal Injury in Sepsis

description: <b><i>Introduction:</i></b> Gap junctions can transmit signals between cells, including miRNAs, leading to the amplification of adjacent cell damage. No previous study has addressed gap junctions and miRNAs in sepsis because the internal mechanism of sepsis-induced intestinal injury is complex. Therefore, we studied the relationship between connexin43 (Cx43) and miR-181b and provided a research direction for further study of sepsis. <b><i>Methods:</i></b> A mouse caecal ligation and puncture method was used to construct a mouse sepsis model. Firstly, damage to intestinal tissues at different time points was analysed. The levels of Cx43, miR-181b, Sirt1, and FOXO3a in intestinal tissues and the transcription and translation of the apoptosis-related genes <i>Bim and puma</i>, which are downstream of FOXO3a were analysed. Secondly, the effect of Cx43 levels on miR-181b and Sirt1/FOXO3a signalling pathway activity was explored by using the Cx43 inhibitor heptanol. Finally, luciferase assays were used to determine miR-181b binding to the predicted target sequence. <b><i>Results:</i></b> The results show that during sepsis, intestinal injury becomes increasingly worse with time, and the expression of Cx43 and miR-181b increase. In addition, we found that heptanol could significantly reduce intestinal injury. This finding indicates that inhibiting Cx43 regulates the transfer of miR-181b between adjacent cells, thereby reducing the activity of the Sirt1/FOXO3a signalling pathway and reducing the degree of intestinal injury during sepsis. <b><i>Conclusions:</i></b> In sepsis, the enhancement of Cx43 gap junctions leads to an increase in miR-181b intercellular transfer, affects the downstream SIRT1/FOXO3a signalling pathway and causes cell and tissue damage.
DOI: 10.6084/m9.figshare.23541447
title: Supplementary Material for: Patient Preferences: Results of a German Adaptive Choice-Based Conjoint Analysis (Market Research Study Sponsored by Eli Lilly and Company) in Patients on Palliative Treatment for Advanced Breast Cancer

description: <b><i>Introduction:</i></b> Integration of patient preferences into shared decision making improves disease-related outcomes, but such data from patients with advanced breast cancer (aBC) are limited. The objective of this study was to demonstrate the relative importance of overall survival (OS) and progression-free survival (PFS) in relation to quality of life (QoL) and therapy-associated side effects from the perspective of patients with aBC. <b><i>Methods:</i></b> Postmenopausal patients with hormone receptor-positive, human epidermal growth factor receptor 2-negative aBC receiving first- or second-line treatment were recruited throughout Germany. Patient-relevant attributes for aBC therapy assessment were collected using a stepwise multimodal approach. A conjoint matrix was developed, resulting in 2 attributes for therapy goals (OS and PFS), 4 for QoL, and 6 for side effects. An online quantitative survey was then performed using adaptive choice-based conjoint (ACBC) methodology. <b><i>Results:</i></b> The quantitative survey included 104 patients: 67 (64.4%) receiving first-line treatment and 37 (35.6%) receiving second-line treatment. The QoL attribute “physical agility and mobility” received the highest utility score (19.4 of 100%), reflecting the greatest importance to patients, followed by treatment goals (OS [15.2%] and PFS [14.4%]). Therapy-related side effects were less important, with nausea/vomiting being the most important (9.3%), followed by infection (6.4%) and hair loss (5.0%). The McFadden pseudo <i>R</i><sup>2</sup> (0.805), the root likelihood (0.864), and the χ<sup>2</sup> test (2,809.041; <i>p</i> &lt; 0.0001) indicated a very good fit of the statistical model. <b><i>Conclusion:</i></b> Using ACBC analysis, it appears that QoL, OS, and PFS are most important to postmenopausal patients with aBC in relation to cancer treatment. Side effects seem to be less important if OS or PFS are prolonged and the QoL is maintained. Thus, QoL, OS, and PFS should be considered equally when making treatment decisions in aBC.
DOI: 10.6084/m9.figshare.23544432
title: Supplementary Material for: Exploring the Associations and Molecular Impacts of miR-146a/rs2910164 and miR-196a2/rs185070757 with Rheumatoid Arthritis in a Pakistani Population

description: <b><i>Introduction:</i></b> MicroRNAs (miRNAs) are a new class of molecules that participate in post-transcriptional regulation of gene expression and hence have been reported to have a crucial role in the pathogenesis of rheumatoid arthritis (RA). We aimed to investigate the association of miR-146a rs2910164 (G/C) and miR-196a2 rs185070757 (T/G) with RA susceptibility in Pakistani patients and to bioinformatically predict the molecular function of these miRNAs. <b><i>Methods:</i></b> A case-control study on 600 individuals was conducted, including 300 RA patients and 300 matching healthy controls. Genotyping was performed by tetra-primer amplification of refractory mutation system-polymerase chain reaction, and the association between variants and RA was statistically determined using different models. <b><i>Results:</i></b> For the variant rs2910164 (G/C) in miR-146a, no difference in genotype distribution was observed between RA cases and controls, as determined using co-dominant (χ<sup>2</sup> = 4.33; <i>p</i> = 0.114), homozygous dominant (C/C vs. G/G + C/G) (OR = 0.740 [0.531–1.032]; <i>p</i> = 0.091), homozygous recessive (G/G vs. C/C + G/C) (odds ratio [OR] = 01.432 [0.930–2.206]; <i>p</i> = 0.126), heterozygous (G/C vs. C/C + G/G) (OR = 1.084 [0.786–1.494]; <i>p</i> = 0.682), and additive (OR 0.778 [0.617–0.981]; <i>p</i> = 0.039) models. Similarly, the GT genotype in the rs185070757 (T/G) miR-196a2 variant did not differ between cases and controls with any models (<i>p</i> &gt; 0.05). For the first time, we report no association of miR-146a rs2910164 (G/C) and miR-196a2 rs185070757 (T/G) with RA in a Pakistani population. A subsequent bioinformatic analysis revealed that the CC genotype of miR-146a rs2910164 might have a protective role against RA pathogenesis, with no effect observed with the miR-196a2 rs185070757. <b><i>Conclusion:</i></b> Our findings suggest that these miRNAs might have little-to-no impact on the RA pathogenesis in the Pakistani population.
DOI: 10.6084/m9.figshare.23559582
title: Supplementary Material for: Acacetin alleviates cardiac fibrosis via TGF-β1/Smad and AKT/mTOR signal pathways in spontaneous hypertensive rats

description: Introduction: Attenuation of the activation of cardiac fibroblasts contributes to reduce the excessive extracellular matrix deposition and cardiac structural remodeling in hypertensive hearts. Acacetin has shown to play a protective role in doxorubicin-induced cardiomyopathy. The aim of this study was to investigate the potential molecular mechanisms underlying the protective role of acacetin on hypertension-induced fibrosis in the heart. Methods: Echocardiography, pathological morphological and western-blotting techniques were used to evaluate the anti-fibrosis effects in spontaneous hypertensive rat (SHR) which were daily intragastric administrated with acacetin (10mg/kg and 20mg/kg) for 6 weeks. Angiotensin II (Ang II) was used to induce cellular fibrosis in human cardiac fibroblasts in the absence and presence of acacetin treatment for 48 hours. Results: Acacetin alleviated hypertension-induced left ventricular posterior wall thickness and relieved cardiac remodeling in SHR. The expressions of collagen-1, collagen-III and alpha-SMA were remarkedly decreased after treatment with acacetin (n=6, P&lt;0.05). The wound closure rate and the number of migratory cells per field were decreased by 3 and 10 µmol/L acacetin in Ang II-treated fibroblasts (n=6, P &lt; 0.05). Acacetin (10µmol/L) inhibited Ang II-induced upregulation of collagen-1 and collagen-III (n=6, P &lt; 0.05), and downregulation of the expression of alpha-SMA reversed the differentiation of fibroblasts to myofibroblasts. Acacetin also decreased the expression of TGF-β1, the fraction of p-Smad3/Smad3, and p-AKT and p-mTOR, but increased the expression of Smad7 (n=6, P &lt; 0.05). Furthermore, acacetin inhibited TGF-β1 agonist SRI and AKT agonist SC79 caused fibrotic effect. Conclusion: In summary, acacetin inhibits the hypertension-associated cardiac fibrotic processes through regulating TGF-β/Smad3, AKT/mTOR signal transduction pathways.
DOI: 10.6084/m9.figshare.23731314
title: Fully Resolved Assembly and Comparative Genomics of Fusarium proliferatum DSM106835

description: The genome annotation and functional classification of<em> Fusarium proliferatum </em>DSM106835 and its subfiles.
DOI: 10.6084/m9.figshare.23939478
title: Supplementary Material for: The External Validation of the Nursing Homes Short Depression Inventory in Older Adults with Major Neurocognitive Disorders in Long-Term Care Centers

description: Introduction: Depression is often difficult to detect in long-term care (LTC) patients with major neurocognitive disorders (MNCD) and an observer-rated screening scale could facilitate assessments. This study aimed to establish the external validity and reliability of the Nursing Homes Short Depression Inventory (NH-SDI) in LTC patients with MNCD and to compare its estimates to the Cornell Scale for Depression in Dementia (CSDD), the most used scale for depression in MNCD. Methods: A focus discussion group of experts assessed the content validity of the NH-SDI. Then, a convenience sample of 93 LTC patients with MNCD were observer-rated by trained nurses with the NH-SDI and CSDD. For 57 patients, a medical assessment of depression was obtained, and screening accuracy estimates generated. Results: The prevalence of depression was 8.8% as per reference standard. NH-SDI's content validity was judged acceptable with minor item wording modifications and specifications. The NH-SDI (cut-off &gt; 3) achieved 100% (95%CI: 46-100%) sensitivity, 83% (95%CI: 69-91%) specificity and 36% (95%CI: 14-64%) positive predictive value (PPV). The CSDD (cut-off &gt; 3) achieved 100% (95%CI: 46-100%) sensitivity, 75% (95%CI: 61-86%) specificity and 28% (95%CI: 11-54%) PPV. No significant differences in AUCs were found between scales. The NH-SDI and CSDD were highly correlated (rs = 0.913; p &lt; 0.001) and reliable (ICC = 0.77, p &lt; 0.001). Discussion/Conclusion: The NH-SDI appears valid and reliable in LTC patients with MNCD and quicker than the CSDD to rule-out depression in a busy or short-staffed setting.
DOI: 10.6084/m9.figshare.24204060
title: Supplementary Material for: Acanthosis Nigricans in a patient with urothelial carcinoma treated with PD-L1 inhibitor Avelumab, and secondary adrenal insufficiency

description: Acanthosis Nigricans (AN) describes a hyperkeratotic and hyperpigmented skin changes and its pathophysiology is linked to activation of epidermal growth factor receptors. Current literature shows AN is most commonly diagnosed at time of the underlying pathology, which may occur in benign or malignant conditions. This case presentation demonstrates occurrence of AN following diagnosis of urothelial carcinoma and ongoing treatment with PD-L1 inhibitor immunotherapy. Subsequent investigations ruled out a secondary malignancy or disease progression, however metabolic screening identified secondary glucocorticoid-induced adrenal insufficiency. AN was persistent in this patient despite adequate treatment, which highlights its co-occurrence in both benign and paraneoplastic conditions.
DOI: 10.6084/m9.figshare.24260041
title: Supplementary Material for: Complete response of Triple Negative Metaplastic Carcinoma of the Breast Using Pembrolizumab

description: Metaplastic breast cancer (MpBC) is a rare form of breast malignancy with a poor prognosis and limited treatment guidance. Here, we report on a case of triple-negative MpBC that was successfully treated following the Keynote-522 clinical algorithm using pembrolizumab, paclitaxel, carboplatin, adriamycin and cyclophosphamide in a neo-adjuvant fashion. The radiographic and histologic findings of the tumor are reviewed here along with the treatment regimen and response. No major toxicities associated with pembrolizumab were observed in this case. This case report serves as an example of complete pathological response of triple-negative MpBC with pembrolizumab plus chemotherapy and demonstrates the need for further research on chemoimmunotherapy for MpBC.
DOI: 10.6084/m9.figshare.24271447
title: Supplementary Material for: Three pediatric patients with congenital nephrogenic diabetes insipidus due to AVPR2 nonsense mutations and different clinical manifestations

description: Congenital nephrogenic diabetes insipidus (CNDI), a rare hereditary disorder, is characterized by the inability of the kidneys to concentrate urine in response to the antidiuretic hormone arginine vasopressin (AVP); as a result, large volumes of unconcentrated urine are excreted. In addition to the clinical manifestations of CNDI, such as dehydration and electrolyte disturbances (hypernatremia and hyperchloremia), developmental delay can result without prompt treatment. In approximately 90% of cases, CNDI is an X-linked disease caused by mutations in the arginine vasopressin receptor 2 (AVPR2) gene. In approximately 9% of cases, CNDI is an autosomal recessive disease caused by mutations in the water channel protein aquaporin 2 (AQP2), and 1% of cases are autosomal dominant. We report a case of CNDI caused by a novel AVPR2 nonsense mutation, c.520C&gt;T (p.Q174X), and cases of siblings in another family who had a different AVPR2 nonsense mutation, c.852G&gt;A (p.W284X). Both cases responded well to treatment with hydrochlorothiazide and spironolactone. If CNDI is suspected especially in carriers and neonates, aggressive genetic testing, and early treatment may alleviate growth disorders and prevent irreversible central nervous system disorders and developmental delay.
DOI: 10.22002/d1.2152
title: Images for "Motor processivity and speed determine structure and dynamics of microtubule-motor assemblies"

description: Images of asters formed by light activation of various activation regions. The structure of the folders is dat > motor name > excitation diameter. Images from the first frames are also included for background subtraction and flattening the field. Motor competition images are also included under the folder "motor_competition_images." These are separated between K401-Ncd and Kif11-Ncd. Finally, calculated merger speeds are included.
description: Related Publication:
"Motor processivity and speed determine structure and dynamics of microtubule-motor assemblies"
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