cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.22785366
title: Critical modernity, creative thinking, and innovation: startups in Brazil

description: Abstract This study aims to understand the criteria that influence the decision-making process of selecting startups that have innovated successfully. In this article, this kind of selection was made by venture capital enterprises. We studied the view of the investors, venture capital professionals, and startup entrepreneurs interviewed. We present the actual global characteristics of the main cities where innovation takes place and the modernism and critical modernism aspects and creative thinking beliefs (Einstein, Habermas). The qualitative research was carried out using an exploratory approach and case study methodology based on semi-structured interviews (nine in total) with professionals from venture capital funds, startup entrepreneurs, and investors. The interviews confirmed several relationships between theories found in the business management literature. Findings such as post-bureaucratic environments (Heckscher), Mintzberg’s (1995) Adhocracy, and Simon’s decision-making process (1987) for pattern recognition were corroborated by the analysis of the interviews. We present some initiatives for innovation such as Station F in France, El Espacio La Nave, Madrid, the Project Porto Maravilha in Rio, and Vila Olimpia e Paulista avenue, São Paulo.
DOI: 10.6084/m9.figshare.22785367
title: Comparison between Vacuum-Assisted Closure Technique and Conventional Approach in Patients with Mediastinitis After Isolated Coronary Artery Bypass Graft Surgery

description: ABSTRACT Introduction: Median sternotomy is the most preferred approach in heart surgery. Post-sternotomy mediastinitis is a catastrophic and potentially life-threatening complication with an incidence rate of 0.15% to 5%, and its overall mortality rate reaches 47%. In this study, we aimed to compare the results of vacuum-assisted closure technique and the conventional methods on the management of mediastinitis following isolated coronary artery bypass graft surgery. Methods: Between February 2001 and July 2013, 32,106 patients who underwent cardiac operations were evaluated retrospectively. One hundred and fourteen patients who developed post-sternotomy mediastinitis were included in this study. The patients were divided into two groups and compared - vacuum-assisted closure group (n=52, 45.6%) and conventional treatment group (n=62, 54.4%). Results: There were no differences between the two groups according to the patients’ characteristics, surgical data, and mediastinal cultures. However, we found that total treatment duration for post-sternotomy mediastinitis, time interval from diagnosis to negative culture, hospitalization time, and in-hospital mortality were statistically significantly lower in the vacuum-assisted closure group than in the conventional treatment group (P&lt;0.001, P&lt;0.001, P&lt;0.001, and P=0.03, respectively). Conclusion: This study demonstrates that the vacuum-assisted closure technique improves the medical outcome of patients with post-sternotomy mediastinitis compared with the conventional treatment. The vacuum-assisted closure is a safe and more effective treatment modality for patients with post-sternotomy mediastinitis after cardiac surgery with reasonable morbidity and mortality.
DOI: 10.6084/m9.figshare.22785367.v1
title: Comparison between Vacuum-Assisted Closure Technique and Conventional Approach in Patients with Mediastinitis After Isolated Coronary Artery Bypass Graft Surgery

description: ABSTRACT Introduction: Median sternotomy is the most preferred approach in heart surgery. Post-sternotomy mediastinitis is a catastrophic and potentially life-threatening complication with an incidence rate of 0.15% to 5%, and its overall mortality rate reaches 47%. In this study, we aimed to compare the results of vacuum-assisted closure technique and the conventional methods on the management of mediastinitis following isolated coronary artery bypass graft surgery. Methods: Between February 2001 and July 2013, 32,106 patients who underwent cardiac operations were evaluated retrospectively. One hundred and fourteen patients who developed post-sternotomy mediastinitis were included in this study. The patients were divided into two groups and compared - vacuum-assisted closure group (n=52, 45.6%) and conventional treatment group (n=62, 54.4%). Results: There were no differences between the two groups according to the patients’ characteristics, surgical data, and mediastinal cultures. However, we found that total treatment duration for post-sternotomy mediastinitis, time interval from diagnosis to negative culture, hospitalization time, and in-hospital mortality were statistically significantly lower in the vacuum-assisted closure group than in the conventional treatment group (P&lt;0.001, P&lt;0.001, P&lt;0.001, and P=0.03, respectively). Conclusion: This study demonstrates that the vacuum-assisted closure technique improves the medical outcome of patients with post-sternotomy mediastinitis compared with the conventional treatment. The vacuum-assisted closure is a safe and more effective treatment modality for patients with post-sternotomy mediastinitis after cardiac surgery with reasonable morbidity and mortality.
DOI: 10.6084/m9.figshare.22785369
title: Transfer of knowledge of retirement workers in a higher education institution

description: Abstract We sought to understand the importance and contribution of knowledge transfer (KT) of workers in the retirement phase in a higher education institution (HEI). Such research is justified by the fact that KT in retirement is approached by different areas but with little emphasis on administrative sciences. A qualitative case study was carried out based on the theoretical framework of knowledge creation and transference, in which retired workers and managers and young workers participated. Semi-structured interviews and focus groups were carried out with the participation of 32 people and non-participant observation with about 260 workers. Data were organized with the support of NVivo®11 software, triangulated, and analyzed using content analysis. It is stated that KT contributes to improve work relationships and bring people together, acquires a greater degree of autonomy and recognition, perceives opportunities for professional and personal growth, and contributes to the HEI since the institutional history is valued, processes are improved, organizational costs are reduced, and the organizational climate is optimized. It is concluded that different knowledge is important for HEIs and the people who are part of them, and the need to implement actions is highlighted so that knowledge is not lost when the worker retires.
DOI: 10.6084/m9.figshare.22785369.v1
title: Transfer of knowledge of retirement workers in a higher education institution

description: Abstract We sought to understand the importance and contribution of knowledge transfer (KT) of workers in the retirement phase in a higher education institution (HEI). Such research is justified by the fact that KT in retirement is approached by different areas but with little emphasis on administrative sciences. A qualitative case study was carried out based on the theoretical framework of knowledge creation and transference, in which retired workers and managers and young workers participated. Semi-structured interviews and focus groups were carried out with the participation of 32 people and non-participant observation with about 260 workers. Data were organized with the support of NVivo®11 software, triangulated, and analyzed using content analysis. It is stated that KT contributes to improve work relationships and bring people together, acquires a greater degree of autonomy and recognition, perceives opportunities for professional and personal growth, and contributes to the HEI since the institutional history is valued, processes are improved, organizational costs are reduced, and the organizational climate is optimized. It is concluded that different knowledge is important for HEIs and the people who are part of them, and the need to implement actions is highlighted so that knowledge is not lost when the worker retires.
DOI: 10.5281/zenodo.7907062
title: Deep subduction of the Philippine Sea slab and formation of slab window beneath central Japan

description: The travel-time data, the velocity model from seismic tomography and the temperature distributions from numerical simulation.
DOI: 10.5281/zenodo.7907061
title: Deep subduction of the Philippine Sea slab and formation of slab window beneath central Japan

description: The travel-time data, the velocity model from seismic tomography and the temperature distributions from numerical simulation.
DOI: 10.6084/m9.figshare.22785373.v1
title: DNA rare copy number alterations in Reinke’s Edema

description: Abstract Introduction: Reinke’s Edema (RE) is a laryngeal lesion related to excessive tobacco smoking, voice overuse, and laryngopharyngeal reflux. Although the risk of malignancy has been considered low in literature, RE is classified among precancerous lesions. Objectives: We investigated DNA Copy Number Alterations (CNAs) in specimens of RE and its potential association with malignant progression. Methods: We used array-based comparative genomic hybridization (aCGH, Agilent 4 × 180 K platform) to study eight RE cases. All patients were heavy tobacco users for at least 30 years, and none of them progressed to cancer in the follow-up (&gt;8 years). Two RE presented mild dysplasia, one moderate dysplasia, and no histological alterations were found in the remaining five cases. CNAs were compared with the Database of Genomic Variants (DGV) and genes mapped on altered regions had their functions annotated. Results: Six of eight patients showed different rare copy number alterations on chromosomes 2q37.3, 4q13.1, 4q13.3, 7q11.22, 10p14, and 13q34. A gain of the whole chromosome 8 were detected in one case. Of interest, four of eight RE cases showed copy number imbalances involving genes previously described in several tumor types (RASA3, COL6A3, LINC00707, LINP1, SMR3A, and SMR3B). Conclusion: The genomic imbalances herein found in RE have the potential to contribute to the phenotype but with limited or no risk of cancer. A long-term follow-up in a large series of patients could clarify the mechanisms involved in the malignant progression of RE. Level of evidence: 4.
DOI: 10.6084/m9.figshare.22785373
title: DNA rare copy number alterations in Reinke’s Edema

description: Abstract Introduction: Reinke’s Edema (RE) is a laryngeal lesion related to excessive tobacco smoking, voice overuse, and laryngopharyngeal reflux. Although the risk of malignancy has been considered low in literature, RE is classified among precancerous lesions. Objectives: We investigated DNA Copy Number Alterations (CNAs) in specimens of RE and its potential association with malignant progression. Methods: We used array-based comparative genomic hybridization (aCGH, Agilent 4 × 180 K platform) to study eight RE cases. All patients were heavy tobacco users for at least 30 years, and none of them progressed to cancer in the follow-up (&gt;8 years). Two RE presented mild dysplasia, one moderate dysplasia, and no histological alterations were found in the remaining five cases. CNAs were compared with the Database of Genomic Variants (DGV) and genes mapped on altered regions had their functions annotated. Results: Six of eight patients showed different rare copy number alterations on chromosomes 2q37.3, 4q13.1, 4q13.3, 7q11.22, 10p14, and 13q34. A gain of the whole chromosome 8 were detected in one case. Of interest, four of eight RE cases showed copy number imbalances involving genes previously described in several tumor types (RASA3, COL6A3, LINC00707, LINP1, SMR3A, and SMR3B). Conclusion: The genomic imbalances herein found in RE have the potential to contribute to the phenotype but with limited or no risk of cancer. A long-term follow-up in a large series of patients could clarify the mechanisms involved in the malignant progression of RE. Level of evidence: 4.
DOI: 10.6084/m9.figshare.22785375
title: Diagnostic utility of salivary pepsin in laryngopharyngeal reflux: a systematic review and meta-analysis

description: Abstract Objective: Salivary pepsin has emerged as a biomarker for Laryngopharyngeal Reflux (LPR), which, however, has been questioned for its efficacy due to a lack of supporting medical data. Therefore, this study analyzed the diagnostic value of salivary pepsin for LPR and assessed a better cutoff value. Methods: Studies were searched in PubMed, Embase, and Cochrane Library from their receptions to October 1, 2021. Then, RevMan 5.3 and Stata 14.0 were utilized to summarize the diagnostic indexes for further meta-analysis. Data were separately extracted by two reviewers according to the trial data extraction form of the Cochrane Handbook. The risk of bias in Randomized Control Trials (RCTs) was evaluated with the Cochrane Risk of Bias Tool. Results: A total of 16 studies matched the criteria and were subjected to meta-analysis. The results revealed a pooled sensitivity of 61% (95% CI 50%–71%), a pooled specificity of 67% (95% CI 48%–81%), a positive likelihood ratio of 2 (95% CI 1.2–2.8), a negative likelihood ratio of 0.58 (95% CI 0.47–0.72), and the area under the receiver operating characteristic curve of 0.67 (95% CI 0.63–0.71). Subgroup analyses indicated that the cutoff value of pepsin at 50 ng/mL had a higher degree of diagnostic accuracy than that of pepsin at 16 ng/mL in cohort studies. Conclusion: The review demonstrated low diagnostic performance of salivary pepsin for LPR and that the cutoff value of 50 ng/mL pepsin had superior diagnostic accuracy. Nevertheless, the diagnostic value may vary dependent on the utilized diagnostic criteria. Therefore, additional research is needed on the improved way of identifying salivary pepsin in the diagnosis of LPR, and also longer-term and more rigorous RCTs are warranted to further assess the effectiveness of salivary pepsin.
DOI: 10.6084/m9.figshare.22785375.v1
title: Diagnostic utility of salivary pepsin in laryngopharyngeal reflux: a systematic review and meta-analysis

description: Abstract Objective: Salivary pepsin has emerged as a biomarker for Laryngopharyngeal Reflux (LPR), which, however, has been questioned for its efficacy due to a lack of supporting medical data. Therefore, this study analyzed the diagnostic value of salivary pepsin for LPR and assessed a better cutoff value. Methods: Studies were searched in PubMed, Embase, and Cochrane Library from their receptions to October 1, 2021. Then, RevMan 5.3 and Stata 14.0 were utilized to summarize the diagnostic indexes for further meta-analysis. Data were separately extracted by two reviewers according to the trial data extraction form of the Cochrane Handbook. The risk of bias in Randomized Control Trials (RCTs) was evaluated with the Cochrane Risk of Bias Tool. Results: A total of 16 studies matched the criteria and were subjected to meta-analysis. The results revealed a pooled sensitivity of 61% (95% CI 50%–71%), a pooled specificity of 67% (95% CI 48%–81%), a positive likelihood ratio of 2 (95% CI 1.2–2.8), a negative likelihood ratio of 0.58 (95% CI 0.47–0.72), and the area under the receiver operating characteristic curve of 0.67 (95% CI 0.63–0.71). Subgroup analyses indicated that the cutoff value of pepsin at 50 ng/mL had a higher degree of diagnostic accuracy than that of pepsin at 16 ng/mL in cohort studies. Conclusion: The review demonstrated low diagnostic performance of salivary pepsin for LPR and that the cutoff value of 50 ng/mL pepsin had superior diagnostic accuracy. Nevertheless, the diagnostic value may vary dependent on the utilized diagnostic criteria. Therefore, additional research is needed on the improved way of identifying salivary pepsin in the diagnosis of LPR, and also longer-term and more rigorous RCTs are warranted to further assess the effectiveness of salivary pepsin.
DOI: 10.6084/m9.figshare.22785376
title: Morphophysiological and biochemical changes in Enterolobium contortisiliquum seedlings under abiotic stresses

description: ABSTRACT Among the main problems that compromise the development of forest species are water and salt stresses, especially in the early stages of development, when seedlings are more sensitive. Thus, the objective of this study was to evaluate the morphophysiological and biochemical changes in Enterolobium contortisiliquum seedlings subjected to abiotic stresses. The experimental design was randomized complete blocks (RCB), composed of five treatments, with four replicates, and the experimental plot consisted of twenty plants. From the 31st day after sowing, when the seedlings reached approximately 15 cm in height, they began to receive the treatments, which consisted of different levels of electrical conductivity of irrigation water (0.3; 2; 4; 6; 8 dS m-1) for salt stress and periods of water restriction (0; 4; 8; 12 and 16 days without irrigation) for water stress. The traits evaluated were: plant height, root length, stem diameter, number of leaves, leaf area, total dry matter, Dickson quality index, height/shoot dry matter ratio, total soluble sugars, starch, total amino acids and proline. An increase in the electrical conductivity of irrigation water and days without irrigation compromised the development of E. contortisiliquum seedlings, which was intensified from 2 dS m-1 and four days without irrigation for salt and water stresses, respectively. The mechanism of survival of E. contortisiliquum to abiotic stresses involves reduction in the growth and quality of seedlings, with activation of biochemical defense mechanisms of the species.
DOI: 10.6084/m9.figshare.22785376.v1
title: Morphophysiological and biochemical changes in Enterolobium contortisiliquum seedlings under abiotic stresses

description: ABSTRACT Among the main problems that compromise the development of forest species are water and salt stresses, especially in the early stages of development, when seedlings are more sensitive. Thus, the objective of this study was to evaluate the morphophysiological and biochemical changes in Enterolobium contortisiliquum seedlings subjected to abiotic stresses. The experimental design was randomized complete blocks (RCB), composed of five treatments, with four replicates, and the experimental plot consisted of twenty plants. From the 31st day after sowing, when the seedlings reached approximately 15 cm in height, they began to receive the treatments, which consisted of different levels of electrical conductivity of irrigation water (0.3; 2; 4; 6; 8 dS m-1) for salt stress and periods of water restriction (0; 4; 8; 12 and 16 days without irrigation) for water stress. The traits evaluated were: plant height, root length, stem diameter, number of leaves, leaf area, total dry matter, Dickson quality index, height/shoot dry matter ratio, total soluble sugars, starch, total amino acids and proline. An increase in the electrical conductivity of irrigation water and days without irrigation compromised the development of E. contortisiliquum seedlings, which was intensified from 2 dS m-1 and four days without irrigation for salt and water stresses, respectively. The mechanism of survival of E. contortisiliquum to abiotic stresses involves reduction in the growth and quality of seedlings, with activation of biochemical defense mechanisms of the species.
DOI: 10.5281/zenodo.6390797
title: Human embryo time-lapse video dataset

description: A human embryo time-lapse video dataset.
DOI: 10.5281/zenodo.6390798
title: Human embryo time-lapse video dataset

description: A human embryo time-lapse video dataset.
DOI: 10.5281/zenodo.7885222
title: Human embryo time-lapse video dataset

description: A human embryo time-lapse video dataset.
DOI: 10.5281/zenodo.7912264
title: Human embryo time-lapse video dataset

description: A human embryo time-lapse video dataset.
DOI: 10.6084/m9.figshare.22785378
title: Geastrum tupiense: a new earthstar fungi species from the Brazilian Atlantic Forest and a new insertion in the Velutina subsection (Geastrales, Basidiomycota)

description: Abstract Geastrum tupiense is a new species belonging to subsect. Velutina (Sect. Myceliostroma). The fundamental diagnostic characteristics are reddish immature basidiomata and rhizomorphs with bipyramidal crystals. It was found in two areas of the Atlantic Forest biome, considered one of the main hotspots in the world for its high level of endemism and biodiversity. Delimitation of this new species was based on morphological characters and phylogenetic analyses of ITS/LSU nrDNA. Descriptions, phylogenetic tree, photographs, and taxonomic discussion are provided.
DOI: 10.6084/m9.figshare.22785378.v1
title: Geastrum tupiense: a new earthstar fungi species from the Brazilian Atlantic Forest and a new insertion in the Velutina subsection (Geastrales, Basidiomycota)

description: Abstract Geastrum tupiense is a new species belonging to subsect. Velutina (Sect. Myceliostroma). The fundamental diagnostic characteristics are reddish immature basidiomata and rhizomorphs with bipyramidal crystals. It was found in two areas of the Atlantic Forest biome, considered one of the main hotspots in the world for its high level of endemism and biodiversity. Delimitation of this new species was based on morphological characters and phylogenetic analyses of ITS/LSU nrDNA. Descriptions, phylogenetic tree, photographs, and taxonomic discussion are provided.
DOI: 10.6084/m9.figshare.22785381
title: Why and how to reform an innovative curriculum? An experience report from Londrina

description: Abstract: Introduction: The undergraduate medical course of the State University of Londrina was the second in Brazil to adopt an integrated curriculum and Problem-Based Learning (PBL). Despite its innovative curriculum, which became a reference for other schools, new assessments showed the need to reform it. Experience Report: Systematic course evaluations showed some issues: difficulties in adaptation of new students attending the first year; disorganized sequence of contents throughout the course; teachers’ lack of motivation for activities from first to the fourth years; need to include new contents; and deterioration of the methodology (PBL) in third and fourth years. A wide collective effort for curricular reform was initiated, which led to important changes, such as: a more welcoming first year, by including mentoring and activities for the leveling of basic knowledge; chronological reorganization of contents; redesign of modules around great areas of knowledge or related specialties; adoption of new and more motivating active learning and teaching methodologies, and the inclusion of new topics/trends. Discussion: The adoption of other active learning and teaching methodologies present strategic advantages in replacement for PBL. Team-Based Learning (TBL) is a more structured method than PBL, so it can help newcomers to adapt to the first year and make it easier to implement active methodologies in a context of teacher shortage. Case-Based Learning (CBL) generates higher motivation and can be more effective to foster the development of clinical reasoning skills in the preclinical years. Conclusion: The new curriculum, incorporating the changes described above, started in 2022. Further evaluations will show whether the changes will improve the course in terms of adaptability, motivation and learning outcomes.