cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.8194934.v1
title: Clinicopathological characteristics of surgically treated localized renal masses in patients previously exposed to chemotherapy

description: ABSTRACT  Purpose: To explore the potential association between renal mass characteristics and a history of chemotherapy.  Materials and methods: A retrospective review of records of patients surgically treated for a localized renal mass between 2000 and 2012 was undertaken following an institutional review board approval. Patients age and sex, renal mass clinical characteristics (radiological size and mode of presentation) and pathological characteristics (diagnosis, renal cell carcinoma subtype, Fuhrman grade and stage) were compared between patients with and without a history of chemotherapy, using Fisher's exact test, Student's t-test and Wilcoxon rank sum test. A multivariate logistic analysis was performed to evaluate the independent association of chemotherapy and tumor pathology.  Results: Of the 1,038 eligible patients, 33 (3%) had a history of chemotherapy. The distribution of clinical stage, renal mass diagnosis, renal cell carcinoma subtype, Fuhrman grade, pathological stage, sex and median age were similar between the general population and the chemotherapy group. However, the latter had a higher rate of incidental presentation (P = 0.003) and a significantly smaller median radiological tumor size (P = 0.01). In a subset analysis of T1a renal cell carcinoma, the chemotherapy group presented an increased rate of high Fuhrman grade (P = 0.03). On multivariate analysis adjusted for radiological tumor size, sex and age the chemotherapy cohort had a 3.92 higher odds for high Fuhrman grade.  Conclusion: Patients with a history of chemotherapy typically present with smaller renal masses that, if malignant, have higher odds of harboring a high Fuhrman grade and thus may not be suitable for active surveillance.
DOI: 10.6084/m9.figshare.8194937
title: Hematologic parameters and Neutrophil / Lymphocyte ratio in the prediction of urethroplasty success

description: ABSTRACT  Objective: The pathophysiology of urethral stricture and its recurrence remains vague and one of the important causes is progressive inflammation. It has been shown in recent years that the neutrophil / lymphocyte ratio is a marker of systemic inflammation and is associated with prognosis in many cardiovascular diseases, malignancies and chronic inflammatory diseases. We assessed simple systemic inflammation markers preoperatively and surgical techniques for urethral stricture recurrence after urethroplasty.  Patients and Methods: After exclusion criteria applied, a total of 117 male cases operated with urethroplasty in our clinic between January 2012 and June 2017 were included in the study and analyzed retrospectively. Localization and length of the strictures of the patients, neutrophil counts and percentages, lymphocyte counts and percentages, and neutrophil / lymphocyte ratios in preoperative peripheral blood samples were statistically analyzed. Recurrent stricture during first 12 months follow-up after the surgery has been assessed as recurrence.  Results: The mean age of the patients was 54.12 ± 16.35 and the mean urethral stricture length was 3.44 ± 1.83 cm. Recurrence was observed in 30.1% of cases who received buccal graft, 30% in penile skin applied cases and 26.1% of cases treated with end-to-end anastomosis and there was no statistically significant difference between neutrophil, lymphocyte, neutrophil / lymphocyte ratio and average stricture segment length between recurrent and non-recurrent cases (p &gt; 0.005).  Conclusions: We consider that neutrophil, lymphocyte counts and their ratio prior to urethroplasty and the technique performed are not parameters that can be used to predict stricture recurrence. Prospective and randomized new trials with larger patient populations are needed to make more accurate judgments about the role of these inflammatory parameters.
DOI: 10.6084/m9.figshare.8194943
title: Palliative Care: Practice of Family Health Strategy Physicians

description: ABSTRACT With the advance of scientific knowledge and increased life expectancy, the illusion has been created that the human being is immortal. In addition, there is a deficiency in current medical training, whereby professional technicians are trained without being prepared to take care of a patient with serious and incurable disease. Towards the middle of the 20th century, there were movements aimed at the humanization of health care, which took into account the integrality of the individual. Palliative care is an approach that improves the quality of life of patients and their families in the face of life-threatening illnesses by relieving suffering, treating pain, and other symptoms of a physical, psychosocial and spiritual nature. Considering that this type of care can be offered in different contexts, it has recently been highlighted that Primary Health Care can be a suitable setting for palliative care assistance. However, there is still a difficulty for Primary Care services in Brazil to offer this kind of assistance. Thus, the research was aimed at understanding the perception of physicians of the Family Health Strategy about palliative care. A descriptive study, with a qualitative approach, using thematic analysis method. The participants were 16 physicians who work in the Family Health Strategy Units of the city of Lavras, Minas Gerais. Data were collected through a semi-structured interview. From the data analysis it was identified that the doctors have incipient knowledge regarding the concept of palliative care and that although they had some type of experience with this type of patient, they encounter difficulties in approaching it in a holistic way. This is mainly due to the deficiency in academic training, which still favors biomedical knowledge and the cure of diseases to the detriment of the relief of human suffering. It is concluded that it is essential that this topic be addressed during medical training, as well as discussed among the professionals already working in the health services so as to provide a better quality of life and death.
DOI: 10.6084/m9.figshare.8194949
title: Safety and effectiveness evaluation of open reanastomosis for obliterative or recalcitrant anastomotic stricture after radical retropubic prostatectomy

description: ABSTRACT  Purpose: To evaluate safety, efficacy and functional outcomes after open vesicourethral re - anastomosis using different approaches based on previous urinary continence.  Materials and Methods: Retrospective study of patients treated from 2002 to 2017 due to vesicourethral anastomosis stricture (VUAS) post radical prostatectomy (RP) who failed endoscopic treatment with at least 3 months of follow-up. Continent and incontinent patients post RP were assigned to abdominal (AA) or perineal approach (PA), respectively. Demographic and perioperative variables were registered. Follow-up was completed with clinical interview, uroflowmetry and cystoscopy every 4 months. Success was defined as asymptomatic patients with urethral lumen that allows a 14 French flexible cystoscope.  Results: Twenty patients underwent open re-anastomosis for VUAS after RP between 2002 and 2017. Mean age was 63.7 years (standard deviation 1.4) and median follow-up was 10 months (range 3 – 112). The approach distribution was PA 10 patients (50%) and AA 10 patients (50%). The mean surgery time and median hospital time were 246.2 ± 35.8 minutes and 4 days (range 2 – 10), respectively with no differences between approaches. No significant complication rate was found. Three patients in the AA group had gait disorder with favorable evolution and no sequels. Estimated 2 years primary success rate was 80%. After primary procedures 89.9% remained stenosis - free. All PA patients remained incontinent, and 90% AA remained continent during follow-up.  Conclusion: Open vesicourethral re - anastomosis treatment is a reasonable treatment option for recurrent VUAS after RP. All patients with perineal approach remained incontinent while incontinence rate in abdominal approach was rather low.
DOI: 10.6084/m9.figshare.8194958
title: Gold Supported on Strontium Surface-Enriched CoFe2O4 Nanoparticles: a Strategy for the Selective Oxidation of Benzyl Alcohol

description: The synthesis of efficient and reusable gold-based catalysts for the selective oxidation of alcohols is a strategy for the development of green processes. Pre-formed nanoparticles syntheses are an easy way to produce controlled-nanosized gold materials; however, the selection of a support is not trivial. Herein, we proposed a CoFe2O4 support enriched with Sr(OH)2, which holds remarkable properties and is suitable for the synthesis of a stable gold-based catalyst for the oxidation of benzyl alcohol. We suggested that the interaction between the CoFe2O4 and the Sr(OH)2 is highly important for the performance of the catalyst. Under the base-free condition of 2.5 h, 100 ºC and 2 bar of O2, the catalyst reached 58% of conversion with 76% of selectivity to benzaldehyde. With K2CO3 addition, the conversion and selectivity to benzaldehyde increased to 87% and 88%, respectively. Any gold leaching was detected in 5 successive runs, attesting the noticeable stability that the catalyst presents. This work provides great potential for the selective oxidation of alcohols with high activity since the magnetic properties of the catalyst provide an easy route and allows the separation of the medium reaction. In addition, we are here proposing an important interaction between the Sr(OH)2 and the magnetic nanoparticles.
DOI: 10.6084/m9.figshare.8194958.v1
title: Gold Supported on Strontium Surface-Enriched CoFe2O4 Nanoparticles: a Strategy for the Selective Oxidation of Benzyl Alcohol

description: The synthesis of efficient and reusable gold-based catalysts for the selective oxidation of alcohols is a strategy for the development of green processes. Pre-formed nanoparticles syntheses are an easy way to produce controlled-nanosized gold materials; however, the selection of a support is not trivial. Herein, we proposed a CoFe2O4 support enriched with Sr(OH)2, which holds remarkable properties and is suitable for the synthesis of a stable gold-based catalyst for the oxidation of benzyl alcohol. We suggested that the interaction between the CoFe2O4 and the Sr(OH)2 is highly important for the performance of the catalyst. Under the base-free condition of 2.5 h, 100 ºC and 2 bar of O2, the catalyst reached 58% of conversion with 76% of selectivity to benzaldehyde. With K2CO3 addition, the conversion and selectivity to benzaldehyde increased to 87% and 88%, respectively. Any gold leaching was detected in 5 successive runs, attesting the noticeable stability that the catalyst presents. This work provides great potential for the selective oxidation of alcohols with high activity since the magnetic properties of the catalyst provide an easy route and allows the separation of the medium reaction. In addition, we are here proposing an important interaction between the Sr(OH)2 and the magnetic nanoparticles.
DOI: 10.6084/m9.figshare.8194961
title: Synthesis of Hydrotalcite-Supported CdTe Semiconductor Nanocrystals for Electrochemical Detection of Ciprofloxacin

description: In this work, CdTe quantum dots (QDs) were controllably grown onto the surface of layered double hydroxide (LDH) aiming to develop a sensitive and selective method for the electrochemical detection of ciprofloxacin (CPX). Emission and absorption spectroscopy results as well as high-resolution transmission electron microscopy (HRTEM) images evidenced the formation of LDH/QD hybrid material. Unmodified carbon paste electrodes (CPE) as well as CPE chemically modified (MCPE) with native LDH and with the LDH/QD hybrid were prepared for CPX detection, revealing that MCPE-LDH/QD had the highest sensitivity for the detection of ciprofloxacin. Optimum detection conditions included a modifier dosage of 20% in MCPE, Britton-Robinson (BR) buffer (pH 6.0) as analytical medium, 300 s accumulation time and a scanning rate of 20 mV s-1. Linear current versus concentration curve was observed from 2.5 × 10-8-1.2 × 10-5 mol L-1 (coefficient of determination (R2) = 0.995), with sensitivity (limit of detection (LOD) = 4.2 × 10-8 mol L-1; limit of quantification (LOQ) = 1.3 × 10-7 mol L-1), precision (relative standard deviation (RSD) = 3.0%), accuracy (94.0%) and satisfactory selectivity in the presence of Zn2+, Fe2+, Cu2+, citric acid and ascorbic acid. Tests of CPX determination in commercial 500 mg ciprofloxacin tablets evidenced the applicability of the method.
DOI: 10.6084/m9.figshare.8194964
title: Embolization of Ruptured Renal Angiomyolipoma in Puerpera

description: Abstract Angiomyolipomas (AMLs) are rare benign tumors derived from mesenchymal tissue and composed of varying degrees of adipose tissue, muscle and blood vessels. Renal AMLs (RAMLs) are the result of a sporadic event, and, in most of cases, the diagnosis is usually incidental, but hemorrhage and shock may be present. During pregnancy, the size of AMLs may increase and they may rupture, probably due to the high expression of hormone receptors, and the increase in maternal circulation and abdominal pressure. The authors present a case of a woman with ruptured RAML submitted to urgent endovascular treatment four days after giving birth by cesarean section.
DOI: 10.6084/m9.figshare.8194964.v1
title: Embolization of Ruptured Renal Angiomyolipoma in Puerpera

description: Abstract Angiomyolipomas (AMLs) are rare benign tumors derived from mesenchymal tissue and composed of varying degrees of adipose tissue, muscle and blood vessels. Renal AMLs (RAMLs) are the result of a sporadic event, and, in most of cases, the diagnosis is usually incidental, but hemorrhage and shock may be present. During pregnancy, the size of AMLs may increase and they may rupture, probably due to the high expression of hormone receptors, and the increase in maternal circulation and abdominal pressure. The authors present a case of a woman with ruptured RAML submitted to urgent endovascular treatment four days after giving birth by cesarean section.
DOI: 10.6084/m9.figshare.8194967.v1
title: Inflated Kumaraswamy distributions

description: Abstract: The Kumaraswamy distribution is useful for modeling variables whose support is the standard unit interval, i.e., (0, 1). It is not uncommon, however, for the data to contain zeros and/or ones. When that happens, the interest shifts to modeling variables that assume values in [0, 1), (0, 1] or [0, 1]. Our goal in this paper is to introduce inflated Kumaraswamy distributions that can be used to that end. We consider inflation at one of the extremes of the standard unit interval and also the more challenging case in which inflation takes place at both interval endpoints. We introduce inflated Kumaraswamy distributions, discuss their main properties, show how to estimate their parameters (point and interval estimation) and explain how testing inferences can be performed. We also present Monte Carlo evidence on the finite sample performances of point estimation, confidence intervals and hypothesis tests. An empirical application is presented and discussed.
DOI: 10.6084/m9.figshare.8194970
title: CHEMICAL CHARACTERIZATION AND CYTOTOXIC ACTIVITY OF THE HETEROPOLYSACHARIDE FROM Colletotrichum gloeosporioides BIOMASS

description: Colletotrichum gloeosporioides biomass was submitted to ethanolic extraction (78 ºC, 12 h) to remove low molecular weight compounds followed by hot aqueous extraction (100 ºC, 4 h, 4x) to obtain polysaccharides. Consecutive freezing/thawing treatments of the aqueous extract yielded a soluble fraction in cold water that was separated on five components (PI to PV) by gel exclusion chromatography on Sepharose CL-6B. The PIV was homogeneous on HPSEC/RID, with apparent MW of 2.8 x 104 g mol-1, Mw/Mn 1.17, 100% of total sugar. The PIV was composed by galactose (61%), glucose (34%) and mannose (5%). 1H and 13C NMR analysis mono- and two-dimensional, homo- (COSY) and heteronuclear (HSQC and HMBC) showed that PIV is a heteropolysacharide with a main chain constituted by β-D-galactofuranosidic units (1→5) and (1→6) linked with some of the β-D-galactofuranosidic (1→6) units substituted in O-3 by α-D-glucopiranosidic residues. Cytotoxic assays (MTT) indicated that the viability of CHO-K1 cells, when exposed to different heteropolysaccharide concentrations, did not show significant differences when compared to the viability of the negative control (CN), in the experimental times of 24 and 48 hours. These results suggest the possibility of new cytotoxic assays in other normal cell lines as well as in tumor cells.
DOI: 10.6084/m9.figshare.8194973.v1
title: COLLECTIVE AUTHORSHIP IN A COMPUTER-BASED ENVIRONMENT IN UNDERGRADUATE CHEMISTRY TEACHING

description: Collective authorship or a text written by more than one person in a computer-based environment can bring significant benefits to chemistry teaching, mainly concerning flexibilizing forms of interaction among those involved and collaborative construction of knowledge. This work investigates collective authorship activities based on constructing argumentative texts in groups with the participation of undergraduate chemistry students. In the activity, those involved, divided into groups, followed the textual production process aiming to present a joint solution for case studies. It was possible to understand aspects of collective work in the authorship process in question regarding collaboration and cooperation based on two perspectives considered crucial for collaborative writing: conditions offered by the electronic platform called eduqui.info, and in which contexts these possibilities were present in the writing process; and the organisational aspects of the activity. Overall, groups chose to collaborate more than cooperate. In other words, data shows that most of the students worked collaboratively in groups.
DOI: 10.6084/m9.figshare.8194976
title: DFT Study of the Interaction between the Ni2+ and Zn2+ Metal Cations and the 1,2-Dithiolene Ligands: Electronic, Geometric and Energetic Analysis

description: Density functional theory (DFT) (B3LYP/6-311++G(d,p)) calculations of the interacting strength 1,2-dithiolene anionic ligands with the [M(OH2)4]2+ and [M(OH2)2]2+ complexes (M = Ni and Zn) were performed. Three series of ligands were studied: compounds with an aromatic ring, with an ethylene moiety and with a heterocyclic ring. The ligands have substituents electron donors and acceptors by induction and resonance. Two substitution reactions were studied: the first is the substitution of two water molecules from the [M(OH2)6]2+ by a dithiolene anionic ligand (L2-) and the second is the substitution of two water molecules from the [M(OH2)4L] by another dithiolene anionic ligand. Geometric, electronic and energetic properties of the substituted aquacations are correlated with the metal-ligand affinity. All the substitution processes for both metal cations are spontaneous and are modulated by the electronic effect of each substituent of the ligand. Geometric parameters and chelation angle are correlated with the interaction strength. The energy decomposition analysis (EDA) results show that the electrostatic component is the main stabilizing term for the monosubstituted complexes, while for the disubstituted complexes the covalent term is the main stabilizing component. The polarization term is the main one to describe the covalent character. Natural bond orbital (NBO) shows the acid-base interaction nature of the metal-ligand bond.
DOI: 10.6084/m9.figshare.8194982.v1
title: CCAAT/enhancer-binding protein alpha (CEBPA) gene haploinsufficiency does not alter hematopoiesis or induce leukemia in Lck-CALM/AF10 transgenic mice

description: Although rare, CALM/AF10 is a chromosomal rearrangement found in immature T-cell acute lymphoblastic leukemia (T-ALL), acute myeloid leukemia, and mixed phenotype acute leukemia of T/myeloid lineages with poor prognosis. Moreover, this translocation is detected in 50% of T-ALL patients with gamma/delta T cell receptor rearrangement, frequently associated with low expression of transcription factor CCAAT/enhancer-binding protein alpha (CEBPA). However, the relevance of CEBPA low expression for CALM/AF10 leukemogenesis has not yet been evaluated. We generated double mutant mice, which express the Lck-CALM/AF10 fusion gene and are haploinsufficient for the Cebpa gene. To characterize the hematopoiesis, we quantified hematopoietic stem cells, myeloid progenitor cells, megakaryocyte-erythrocyte progenitor cells, common myeloid progenitor cells, and granulocyte-macrophage progenitor cells. No significant difference was detected in any of the progenitor subsets. Finally, we tested if Cebpa haploinsufficiency would lead to the expansion of Mac-1+/B220+/c-Kit+ cells proposed as the CALM/AF10 leukemic progenitor. Less than 1% of bone marrow cells expressed Mac-1, B220, and c-Kit with no significant difference between groups. Our results showed that the reduction of Cebpa gene expression in Lck-CALM/AF10 mice did not affect their hematopoiesis or induce leukemia. Our data corroborated previous studies suggesting that the CALM/AF10 leukemia-initiating cells are early progenitors with lymphoid/myeloid differentiating potential.
DOI: 10.6084/m9.figshare.8194985
title: EFFECT OF THE NATURE OF THE ELECTROLYTE AND THE NATURE OF THE INTERFACE ON THE HYDROGEN EVOLUTION POTENTIAL: EXPERIMENTS FOR CHEMISTRY STUDENTS

description: This work presents an experiment done for chemistry students about the effect of the nature of the electrolyte and the nature of the interface on the hydrogen evolution reaction by electrolysis. Two techniques are suggested: method A - two identical copper electrodes in a direct current circuit and method B - three different electrodes in a dc potentiostatic circuit, with copper electrode (working), platinum electrode (counter) and silver-silver chloride-KCl sat electrode (reference). The hydrogen evolution was observed using the A technique by increasing potentials between the two electrodes and the visual observation of the gas production at the cathode. The results showed “semi-quantitative” effect of the pH on the hydrogen evolution. It was observed a larger potential difference in alkaline medium than in acid medium. The results obtained with the B technique from polarization curves showed quantitatively the thermodynamic effect of the pH in addition to the least catalytic effect of copper presented in alkaline medium when compared to copper in acid medium for hydrogen evolution. The technique A can be used in technical courses, high school and general chemistry class for under graduate students. The technique B is appropriate for under graduate electrochemistry class and graduate students.