cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.29314448
title: Supplementary Material for: Mechanisms of KLF10 in regulating proliferation of endometriotic stromal cells in endometriosis

description: Objectives:
Endometriotic stromal cells (ESCs) are extensively found in endometriosis (EM). This study aims to investigate the effects and regulatory mechanisms of KLF10 on the proliferation of ESCs in EM.
Methods: Human ESCs from eutopic and ectopic endometrium were isolated and identified. Levels of KLF10, miR-200c-3p, and lncRNA NEAT1 in cells were detected by RT-qPCR and western blot analysis. Expression of KLF10, miR-200c-3p and NEAT1 were silenced in ectopic ESCs, followed by an assessment of cell proliferation. Chromatin immunoprecipitation and dual-luciferase reporter assays were conducted to analyze the binding of KLF10 to the miR-200c-3p promoter. RNA immunoprecipitation and dual-luciferase reporter assays were performed to analyze the interaction between miR-200c-3p and NEAT1. NEAT1 RNA stability was measured. 
Results: Compared to Eut-ESCs, Ect-ESCs exhibited decreased KLF10 and miR-200c-3p expression and increased NEAT1 expression. Overexpression of KLF10 inhibited the proliferation of Ect-ESCs. Mechanistically, KLF10 transcriptionally promoted miR-200c-3p expression, reducing the binding of miR-200c-3p to NEAT1 and downregulating NEAT1 expression. Combined experimental results showed that miR-200c-3p downregulation or NEAT1 overexpression could alleviate the inhibitory effect of KLF10 overexpression on the proliferation of Ect-ESCs.
Limitations
We only investigated the function of KLF10 in Ect-ESC proliferation of EM on the cellular level, but the effect of KLF10 on abnormal Ect-ESC migration and invasion remains to be explored. Besides, there is no interference experiments performed on Eut-ESCs, and no animal experiment was included. 
Conclusions
KLF10 transcriptionally promoted miR-200c-3p expression, reduced the binding of miR-200c-3p to NEAT1, thus downregulating NEAT1 expression and inhibiting the proliferation of Ect-ESCs.
DOI: 10.6084/m9.figshare.29314448.v1
title: Supplementary Material for: Mechanisms of KLF10 in regulating proliferation of endometriotic stromal cells in endometriosis

description: Objectives:
Endometriotic stromal cells (ESCs) are extensively found in endometriosis (EM). This study aims to investigate the effects and regulatory mechanisms of KLF10 on the proliferation of ESCs in EM.
Methods: Human ESCs from eutopic and ectopic endometrium were isolated and identified. Levels of KLF10, miR-200c-3p, and lncRNA NEAT1 in cells were detected by RT-qPCR and western blot analysis. Expression of KLF10, miR-200c-3p and NEAT1 were silenced in ectopic ESCs, followed by an assessment of cell proliferation. Chromatin immunoprecipitation and dual-luciferase reporter assays were conducted to analyze the binding of KLF10 to the miR-200c-3p promoter. RNA immunoprecipitation and dual-luciferase reporter assays were performed to analyze the interaction between miR-200c-3p and NEAT1. NEAT1 RNA stability was measured. 
Results: Compared to Eut-ESCs, Ect-ESCs exhibited decreased KLF10 and miR-200c-3p expression and increased NEAT1 expression. Overexpression of KLF10 inhibited the proliferation of Ect-ESCs. Mechanistically, KLF10 transcriptionally promoted miR-200c-3p expression, reducing the binding of miR-200c-3p to NEAT1 and downregulating NEAT1 expression. Combined experimental results showed that miR-200c-3p downregulation or NEAT1 overexpression could alleviate the inhibitory effect of KLF10 overexpression on the proliferation of Ect-ESCs.
Limitations
We only investigated the function of KLF10 in Ect-ESC proliferation of EM on the cellular level, but the effect of KLF10 on abnormal Ect-ESC migration and invasion remains to be explored. Besides, there is no interference experiments performed on Eut-ESCs, and no animal experiment was included. 
Conclusions
KLF10 transcriptionally promoted miR-200c-3p expression, reduced the binding of miR-200c-3p to NEAT1, thus downregulating NEAT1 expression and inhibiting the proliferation of Ect-ESCs.
DOI: 10.6084/m9.figshare.29314451
title: Supplementary Material for: Fetoscopic endoluminal tracheal occlusion in congenital diaphragmatic hernia: Unraveling the impact of prematurity and suboptimal fetal lung growth

description: Introduction
Congenital diaphragmatic hernia (CDH) poses significant challenges in both prenatal diagnosis and postnatal management. Fetoscopic endoluminal tracheal occlusion (FETO) aims to enhance survival rates among patients with severe CDH, defined by an observed-to-expected lung-to-head ratio (o/e LHR) of less than 25%. However, issues such as preterm delivery and suboptimal fetal lung growth (SFLG) complicate outcomes. This study examines the effects of these critical risks on FETO results.

Methods
 Data were retrospectively gathered from the multi-institutional CDH Study Group registry on patients with CDH who underwent FETO between 2015 and 2023. Key metrics included CDHSG stage, gestational age (with preterm defined as &lt;37 weeks), o/e-LHR, FETO details, and survival outcomes. The primary outcome was survival, correlated with lung growth and prematurity.

Results
Among 4,524 CDH patients, 106 (2.3%) received FETO, however, 43 patients had o/e-LHR data. Analyses revealed an overall survival rate of 72.1%, though survival for patients delivered preterm with SFLG decreased to 57.1%, while survival among term patients with any increase in fetal lung growth was 90.0%. In univariate analyses, the balloon inflation duration (p=0.05), the use of extracorporeal life support (p=0.04), and the post-balloon o/e LHR (p=0.04) were associated with survival, while in a multivariable logistic regression, the change in o/e-LHR after FETO (OR=1.07, p=0.05) was the only variable found to be significantly associated with survival. 

Conclusion
Prematurity and SFLG are critical factors linked to decreased survival in FETO, with improved o/e-LHR correlating with better outcomes. Future research should focus on refining patient selection and procedural protocols, with a particular focus on mitigating known complications such as preterm delivery and SFLG, to enhance survival rates.
DOI: 10.6084/m9.figshare.29314451.v1
title: Supplementary Material for: Fetoscopic endoluminal tracheal occlusion in congenital diaphragmatic hernia: Unraveling the impact of prematurity and suboptimal fetal lung growth

description: Introduction
Congenital diaphragmatic hernia (CDH) poses significant challenges in both prenatal diagnosis and postnatal management. Fetoscopic endoluminal tracheal occlusion (FETO) aims to enhance survival rates among patients with severe CDH, defined by an observed-to-expected lung-to-head ratio (o/e LHR) of less than 25%. However, issues such as preterm delivery and suboptimal fetal lung growth (SFLG) complicate outcomes. This study examines the effects of these critical risks on FETO results.

Methods
 Data were retrospectively gathered from the multi-institutional CDH Study Group registry on patients with CDH who underwent FETO between 2015 and 2023. Key metrics included CDHSG stage, gestational age (with preterm defined as &lt;37 weeks), o/e-LHR, FETO details, and survival outcomes. The primary outcome was survival, correlated with lung growth and prematurity.

Results
Among 4,524 CDH patients, 106 (2.3%) received FETO, however, 43 patients had o/e-LHR data. Analyses revealed an overall survival rate of 72.1%, though survival for patients delivered preterm with SFLG decreased to 57.1%, while survival among term patients with any increase in fetal lung growth was 90.0%. In univariate analyses, the balloon inflation duration (p=0.05), the use of extracorporeal life support (p=0.04), and the post-balloon o/e LHR (p=0.04) were associated with survival, while in a multivariable logistic regression, the change in o/e-LHR after FETO (OR=1.07, p=0.05) was the only variable found to be significantly associated with survival. 

Conclusion
Prematurity and SFLG are critical factors linked to decreased survival in FETO, with improved o/e-LHR correlating with better outcomes. Future research should focus on refining patient selection and procedural protocols, with a particular focus on mitigating known complications such as preterm delivery and SFLG, to enhance survival rates.
DOI: 10.6084/m9.figshare.29314454
title: Supplementary Material for: The Influence of Renal Function on Safety and Effectiveness of Oral Anticoagulant Treatment Among Frail Elderly Patients with Non- Valvular Atrial Fibrillation and Chronic Kidney Disease

description: Background: The effectiveness and safety of oral anticoagulants (OAC) in patients with chronic kidney disease (CKD) and non-valvular atrial fibrillation (NVAF) in Frail Elderly patients has not been fully established. 
Objectives: To determine the safety and effectiveness related to OACs in Frail Elderly patients with AF and CKD stage II and III. 
Methods: Frail Elderly patients ≥65 years with AF and CKD who received OAC from January 2022 to June 2024 were retrospectively identified. Primary endpoints were composite of ischemic stroke and systemic embolism (IS/SE), and composite of intracranial bleeding (ICH) and/or gastrointestinal (GI) bleeding. Secondary endpoints included any bleeding. 
Results: The study enrolled 365 patients, of whom 141 (38.6%) initiated warfarin therapy and 224 (61.3%) initiated DOACs. CHA2DS2-VASc score was non-significant, (2.6±1.01 vs 2.8±0.89, p value 0.054), for GFR ≥ 60 and GFR &lt; 60 mL/min/1.73m² patients respectively. HAS-BLED score (1.9±0.67 vs 2.3±0.70, p value 0.071) for GFR ≥ 60 and GFR &lt; 60 mL/min/1.73m² patients respectively. While the observed incidence of ICH/GI bleeding was numerically higher in patients with GFR &lt;60 mL/min/1.73m², Cox proportional hazards regression did not demonstrate a statistically significant difference in hazard between the groups. The incidence of composite IS/SE was 8.5% in GFR ≥60 mL/min/1.73m² vs. 8.7% in GFR &lt;60 mL/min/1.73m² (HR 1.02, 95% CI 0.60–1.74, p=0.24). Composite ICH/GI bleeding occurred in 7.1% vs. 9.3% (HR 0.89, 95% CI 0.45–2.72, p=0.41).
Conclusion: In this study comparing Frail Elderly patients with NVAF and CKD stage II versus stage III receiving OACs, we observed No significant difference in the risk of IS/SE or ICH/GI bleeding between groups. These findings suggest that within moderate CKD (eGFR 30-89 mL/min), renal function stage may not independently influence OAC-related outcomes when anticoagulation is well-managed. Our results may not generalize to less frail populations or those with advanced CKD. Further prospective studies with larger sample size are needed to provide clearer guidance on the optimal use of OACs in this challenging clinical scenario.
DOI: 10.6084/m9.figshare.29314454.v1
title: Supplementary Material for: The Influence of Renal Function on Safety and Effectiveness of Oral Anticoagulant Treatment Among Frail Elderly Patients with Non- Valvular Atrial Fibrillation and Chronic Kidney Disease

description: Background: The effectiveness and safety of oral anticoagulants (OAC) in patients with chronic kidney disease (CKD) and non-valvular atrial fibrillation (NVAF) in Frail Elderly patients has not been fully established. 
Objectives: To determine the safety and effectiveness related to OACs in Frail Elderly patients with AF and CKD stage II and III. 
Methods: Frail Elderly patients ≥65 years with AF and CKD who received OAC from January 2022 to June 2024 were retrospectively identified. Primary endpoints were composite of ischemic stroke and systemic embolism (IS/SE), and composite of intracranial bleeding (ICH) and/or gastrointestinal (GI) bleeding. Secondary endpoints included any bleeding. 
Results: The study enrolled 365 patients, of whom 141 (38.6%) initiated warfarin therapy and 224 (61.3%) initiated DOACs. CHA2DS2-VASc score was non-significant, (2.6±1.01 vs 2.8±0.89, p value 0.054), for GFR ≥ 60 and GFR &lt; 60 mL/min/1.73m² patients respectively. HAS-BLED score (1.9±0.67 vs 2.3±0.70, p value 0.071) for GFR ≥ 60 and GFR &lt; 60 mL/min/1.73m² patients respectively. While the observed incidence of ICH/GI bleeding was numerically higher in patients with GFR &lt;60 mL/min/1.73m², Cox proportional hazards regression did not demonstrate a statistically significant difference in hazard between the groups. The incidence of composite IS/SE was 8.5% in GFR ≥60 mL/min/1.73m² vs. 8.7% in GFR &lt;60 mL/min/1.73m² (HR 1.02, 95% CI 0.60–1.74, p=0.24). Composite ICH/GI bleeding occurred in 7.1% vs. 9.3% (HR 0.89, 95% CI 0.45–2.72, p=0.41).
Conclusion: In this study comparing Frail Elderly patients with NVAF and CKD stage II versus stage III receiving OACs, we observed No significant difference in the risk of IS/SE or ICH/GI bleeding between groups. These findings suggest that within moderate CKD (eGFR 30-89 mL/min), renal function stage may not independently influence OAC-related outcomes when anticoagulation is well-managed. Our results may not generalize to less frail populations or those with advanced CKD. Further prospective studies with larger sample size are needed to provide clearer guidance on the optimal use of OACs in this challenging clinical scenario.
DOI: 10.6084/m9.figshare.29314457
title: Supplementary Material for: Evaluating the Applied Knowledge of BRCA Testing Among Spanish-Preferring Latino Americans: The Influence of Acculturation and Literacy

description: Introduction: This study examines applied knowledge about BRCA testing among Spanish-preferring Latino adults in the United States and identifies factors influencing this knowledge, addressing gaps in understanding genetic literacy within this demographic.
Methods: A national survey was conducted with 196 Spanish- preferring Latino adults. Participants completed a questionnaire measuring applied knowledge of BRCA testing, acculturation variables, and literacy measures. Linear regression analysis explored relationships between these factors and applied knowledge scores.
Results: The mean applied knowledge score was 2.33 out of 6, with 26.7% of participants scoring zero. Regression analysis revealed that younger age, female, higher education, higher e-health literacy, and higher numeracy were associated with greater applied knowledge. US identity and critical media literacy was negatively associated with applied knowledge scores.
Conclusion: Spanish-preferring Latino adults demonstrated lower applied knowledge of BRCA testing compared to the general U.S. population, highlighting a significant knowledge disparity. The study identified key factors influencing applied knowledge, such as age, ethnic identity, and e-health literacy, providing insights for developing targeted interventions to improve genetic literacy in this population. These findings can inform culturally competent genetic education initiatives to enhance health outcomes and decision-making regarding genetic testing among Spanish- preferring Latinos.
DOI: 10.6084/m9.figshare.29314457.v1
title: Supplementary Material for: Evaluating the Applied Knowledge of BRCA Testing Among Spanish-Preferring Latino Americans: The Influence of Acculturation and Literacy

description: Introduction: This study examines applied knowledge about BRCA testing among Spanish-preferring Latino adults in the United States and identifies factors influencing this knowledge, addressing gaps in understanding genetic literacy within this demographic.
Methods: A national survey was conducted with 196 Spanish- preferring Latino adults. Participants completed a questionnaire measuring applied knowledge of BRCA testing, acculturation variables, and literacy measures. Linear regression analysis explored relationships between these factors and applied knowledge scores.
Results: The mean applied knowledge score was 2.33 out of 6, with 26.7% of participants scoring zero. Regression analysis revealed that younger age, female, higher education, higher e-health literacy, and higher numeracy were associated with greater applied knowledge. US identity and critical media literacy was negatively associated with applied knowledge scores.
Conclusion: Spanish-preferring Latino adults demonstrated lower applied knowledge of BRCA testing compared to the general U.S. population, highlighting a significant knowledge disparity. The study identified key factors influencing applied knowledge, such as age, ethnic identity, and e-health literacy, providing insights for developing targeted interventions to improve genetic literacy in this population. These findings can inform culturally competent genetic education initiatives to enhance health outcomes and decision-making regarding genetic testing among Spanish- preferring Latinos.
DOI: 10.6084/m9.figshare.29314460
title: Supplementary Material for: Examining Different Motor Learning Paradigms for Improving Balance Recovery Abilities Among Older Adults Random versus Block training: A Randomized Controlled Pilot Trial

description: Introduction: Older adults can reduce the risk of falls after participation in a Perturbation-Based Balance Training (PBBT). We aimed to compare two perturbation motor learning paradigms: random vs block practice. 
Methods: Twenty community-dwelling older adults were recruited and randomly allocated to a random PBBT group (n=8), participants were exposed to unannounced perturbations in multiple directions during each training session, or a block PBBT group (n=12) participants experienced perturbations from a single during every training session during treadmill walking. Both groups received eight training sessions over a four-weeks period that included a concurrent cognitive task during training. Primary outcome measures were parameters of reactive stepping i.e., step-thresholds in walking and kinematics of reactive stepping during walking; and secondary outcome measures were proactive balance, i.e. voluntary step test and cognitive performance. All outcomes were measured before and after PBBT. 
Results: Both PBBT groups improved their ability to cope with higher perturbations post training and a reduction in Center of Mass path displacement during the recovery after the perturbation in walking. No improvement was found in voluntary stepping post training, both groups, however, showed improvement in cognitive performance post-training. 
Discussion: Results show some improvements in reactive stepping performance but not in proactive voluntary stepping in both random and block PBBT methods, with no superiority of one training method over the other. Some improvements in cognitive performance in both groups suggest a transfer effect post training, regardless of training method. Given the small sample size, results are preliminary and should be interpreted with caution.
DOI: 10.6084/m9.figshare.29314460.v1
title: Supplementary Material for: Examining Different Motor Learning Paradigms for Improving Balance Recovery Abilities Among Older Adults Random versus Block training: A Randomized Controlled Pilot Trial

description: Introduction: Older adults can reduce the risk of falls after participation in a Perturbation-Based Balance Training (PBBT). We aimed to compare two perturbation motor learning paradigms: random vs block practice. 
Methods: Twenty community-dwelling older adults were recruited and randomly allocated to a random PBBT group (n=8), participants were exposed to unannounced perturbations in multiple directions during each training session, or a block PBBT group (n=12) participants experienced perturbations from a single during every training session during treadmill walking. Both groups received eight training sessions over a four-weeks period that included a concurrent cognitive task during training. Primary outcome measures were parameters of reactive stepping i.e., step-thresholds in walking and kinematics of reactive stepping during walking; and secondary outcome measures were proactive balance, i.e. voluntary step test and cognitive performance. All outcomes were measured before and after PBBT. 
Results: Both PBBT groups improved their ability to cope with higher perturbations post training and a reduction in Center of Mass path displacement during the recovery after the perturbation in walking. No improvement was found in voluntary stepping post training, both groups, however, showed improvement in cognitive performance post-training. 
Discussion: Results show some improvements in reactive stepping performance but not in proactive voluntary stepping in both random and block PBBT methods, with no superiority of one training method over the other. Some improvements in cognitive performance in both groups suggest a transfer effect post training, regardless of training method. Given the small sample size, results are preliminary and should be interpreted with caution.
DOI: 10.57701/suf.vskt.2009.1-0
title: Versicherungskontenstichprobe 2009
title: SUF
title: VSKT

description: Scientific Use File Versicherungskontenstichprobe (SUF.VSKT): Grundlage des Verlaufsdatensatzes SUF.VSKT ist die Versicherungskontenstichprobe (§ 1 RSVwV Abs. 2, SK79), die ein rund 500.000 Fälle umfassendes, geschichtetes Panel der Versicherten im Alter zwischen 15 und 67 umfasst. Die Grundgesamtheit des SUF.VSKT bilden im Inland lebende deutsche Versicherte, die im Berichtsjahr zwischen 30 und 67 Jahre alt sind. Die Größe der geschichteten Substichprobe umfasst 25 Prozent.Monatsgenau abgebildet wird die soziale Erwerbssituation eines Versicherten, aber auch Informationen über beispielsweise Krankheit, Arbeitslosigkeit, Kindererziehung und Entgelt. Die monatlichen Angaben sind dabei lebenszeitbezogen (Januar des 14. bis Dezember des 65. Lebensjahres) als Querschnitt organisiert. Flankiert wird der Biografie bezogene Teil vom fixen Teil, der neben demographischen Angaben diverse Summen- bzw. Durchschnittsinformationen bereitstellt, die die Rentenanwartschaft des Versicherten beschreiben.
DOI: 10.15468/dl.acqzrm
title: Occurrence Download

description: A dataset containing 1244 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is one of (China, Chinese Taipei)",
 "TaxonKey is Pleione D.Don"
 ]
}

 The dataset includes 1244 records from 49 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0043083-250525065834625/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.25592/uhhfdm.14428
title: An Interview About The History of The Sonko Clan in Giffine And Fode Kabaa (NCAC_RDD_TAPE_0437A)

description: No audio available


 Sonko clan in Giffine
 Fode Kabaa
 Battle of Genier


<em><sup>Alternative names: Foday, Kaba, Dumbuya, Mamanding, Sidibe, Bakary, Bakari, Bakery, Kebba</sup></em>
description: Published by NCAC - National Digital Archive of The Gambia, initiated by University of Hamburg, Asia-Africa-Institute, Germany, funded by Gerda Henkel Foundation, Germany
DOI: 10.25592/uhhfdm.14427
title: An Interview About The History of The Sonko Clan in Giffine And Fode Kabaa (NCAC_RDD_TAPE_0437A)

description: No audio available


 Sonko clan in Giffine
 Fode Kabaa
 Battle of Genier


<em><sup>Alternative names: Foday, Kaba, Dumbuya, Mamanding, Sidibe, Bakary, Bakari, Bakery, Kebba</sup></em>
description: Published by NCAC - National Digital Archive of The Gambia, initiated by University of Hamburg, Asia-Africa-Institute, Germany, funded by Gerda Henkel Foundation, Germany
DOI: 10.15468/dl.z8qpdb
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Cosmarium Corda ex Ralfs, 1848",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "BasisOfRecord is one of (Specimen, Living Specimen, Observation, Human Observation, Machine Observation, Material sample, Literature Occurrence, Material citation, Occurrence evidence)",
 "Geometry POLYGON ((25.5395 -28.5786,20.509 -28.5786,20.509 -32.9007,25.5395 -32.9007,25.5395 -28.5786))"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0043084-250525065834625/datasets/export for details.