cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.19096208.v2
title: A MALDI-TOF mass spectrometry-based haemoglobin chain quantification method for rapid screen of thalassaemia

description: Thalassaemia is one of the most common inherited monogenic diseases worldwide with a heavy global health burden. Considering its high prevalence in low and middle-income countries, a cheap, accurate and high-throughput screening test of thalassaemia prior to a more expensive confirmatory diagnostic test is urgently needed. In this study, we constructed a machine learning model based on MALDI-TOF mass spectrometry quantification of haemoglobin chains in blood, and for the first time, evaluated its diagnostic efficacy in 674 thalassaemia (including both asymptomatic carriers and symptomatic patients) and control samples collected in three hospitals. Parameters related to haemoglobin imbalance (α-globin, β-globin, γ-globin, α/β and α-β) were used for feature selection before classification model construction with 8 machine learning methods in cohort 1 and further model efficiency validation in cohort 2. The logistic regression model with 5 haemoglobin peak features achieved good classification performance in validation cohort 2 (AUC 0.99, 95% CI 0.98–1, sensitivity 98.7%, specificity 95.5%). Furthermore, the logistic regression model with 6 haemoglobin peak features was also constructed to specifically identify β-thalassaemia (AUC 0.94, 95% CI 0.91–0.97, sensitivity 96.5%, specificity 87.8% in validation cohort 2). For the first time, we constructed an inexpensive, accurate and high-throughput classification model based on MALDI-TOF mass spectrometry quantification of haemoglobin chains and demonstrated its great potential in rapid screening of thalassaemia in large populations.Key messagesThalassaemia is one of the most common inherited monogenic diseases worldwide with a heavy global health burden.We constructed a machine learning model based on MALDI-TOF mass spectrometry quantification of haemoglobin chains to screen for thalassaemia. Thalassaemia is one of the most common inherited monogenic diseases worldwide with a heavy global health burden. We constructed a machine learning model based on MALDI-TOF mass spectrometry quantification of haemoglobin chains to screen for thalassaemia.
DOI: 10.5061/dryad.1gq66
title: Data from: Transient recovery dynamics of a predator–prey system under press and pulse disturbances

description: Background: Species recovery after disturbances depends on the strength
 and duration of disturbance, on the species traits and on the biotic
 interactions with other species. In order to understand these complex
 relationships, it is essential to understand mechanistically the transient
 dynamics of interacting species during and after disturbances. We combined
 microcosm experiments with simulation modelling and studied the transient
 recovery dynamics of a simple microbial food web under pulse and press
 disturbances and under different predator couplings to an alternative
 resource. Results: Our results reveal that although the disturbances
 affected predator and prey populations by the same mortality, predator
 populations suffered for a longer time. The resulting diminished predation
 stress caused a temporary phase of high prey population sizes (i.e. prey
 release) during and even after disturbances. Increasing duration and
 strength of disturbances significantly slowed down the recovery time of
 the predator prolonging the phase of prey release. However, the additional
 coupling of the predator to an alternative resource allowed the predator
 to recover faster after the disturbances thus shortening the phase of prey
 release. Conclusions: Our findings are not limited to the studied system
 and can be used to understand the dynamic response and recovery potential
 of many natural predator–prey or host–pathogen systems. They can be
 applied, for instance, in epidemiological and conservational contexts to
 regulate prey release or to avoid extinction risk of the top trophic
 levels under different types of disturbances.
description: Disturbance
 treatmentsCell counts of E. coli
 JM109 (prey) and Tetrahymena pyriformis (predator) in three experimental
 treatments: Undisturbed (control), press and pulse disturbance. All
 treatments were replicated three times.disturbance_treatments.csvGrowth CurvesCell counts [cells/ml] of Escherichia coli JM109 (prey) and Tetrahymena pyriformis (predator) within 24 hours in monocultures and in combination.growth_data.csv
DOI: 10.6084/m9.figshare.19096208.v1
title: A MALDI-TOF mass spectrometry-based haemoglobin chain quantification method for rapid screen of thalassaemia

description: Thalassaemia is one of the most common inherited monogenic diseases worldwide with a heavy global health burden. Considering its high prevalence in low and middle-income countries, a cheap, accurate and high-throughput screening test of thalassaemia prior to a more expensive confirmatory diagnostic test is urgently needed. In this study, we constructed a machine learning model based on MALDI-TOF mass spectrometry quantification of haemoglobin chains in blood, and for the first time, evaluated its diagnostic efficacy in 674 thalassaemia (including both asymptomatic carriers and symptomatic patients) and control samples collected in three hospitals. Parameters related to haemoglobin imbalance (α-globin, β-globin, γ-globin, α/β and α-β) were used for feature selection before classification model construction with 8 machine learning methods in cohort 1 and further model efficiency validation in cohort 2. The logistic regression model with 5 haemoglobin peak features achieved good classification performance in validation cohort 2 (AUC 0.99, 95% CI 0.98–1, sensitivity 98.7%, specificity 95.5%). Furthermore, the logistic regression model with 6 haemoglobin peak features was also constructed to specifically identify β-thalassaemia (AUC 0.94, 95% CI 0.91–0.97, sensitivity 96.5%, specificity 87.8% in validation cohort 2). For the first time, we constructed an inexpensive, accurate and high-throughput classification model based on MALDI-TOF mass spectrometry quantification of haemoglobin chains and demonstrated its great potential in rapid screening of thalassaemia in large populations.Key messagesThalassaemia is one of the most common inherited monogenic diseases worldwide with a heavy global health burden.We constructed a machine learning model based on MALDI-TOF mass spectrometry quantification of haemoglobin chains to screen for thalassaemia. Thalassaemia is one of the most common inherited monogenic diseases worldwide with a heavy global health burden. We constructed a machine learning model based on MALDI-TOF mass spectrometry quantification of haemoglobin chains to screen for thalassaemia.
DOI: 10.6084/m9.figshare.21173887
title: Sex difference in response to non-small cell lung cancer immunotherapy: an updated meta-analysis

description: Studying sex differences in the efficacy of immunotherapy may contribute to the practice of the precision medicine, especially in non-small cell lung cancer (NSCLC), a kind of cancer with sexual bimorphism. Published randomized controlled trials (RCTs), published by PubMed, Medline, Embase, and Scopus, before 15 June 2022, testing immunotherapy (CTLA-4 or PD-1/L1 inhibitor alone, combination or with chemotherapy) versus non-immunotherapy (receiving chemotherapy or placebo only) were included to assess different efficacy between males and females. The primary endpoint was overall survival (OS). This meta-analysis was registered with PROSPERO (CRD42022298439). Sixteen RCTs, involving 10,155 patients with advanced NSCLC, was collected in this meta-analysis. The pooled HR comparing immunotherapy vs non-immunotherapy were 0.76 (95%CI 0.71–0.81) for males and 0.74 (95%CI 0.63–0.87) for females. The pooled HRs comparing immune-checkpoint inhibitors (ICIs) plus chemotherapy versus chemotherapy were 0.79 (95%CI 0.70–0.89) for males and 0.63 (95%CI 0.42–0.92) for females. The pooled HRs comparing ICIs versus chemotherapy were 0.74 (95%CI 0.67–0.81) for males and 0.83 (95%CI 0.73–0.95) for females. In squamous NSCLC, the pooled HRs comparing immunotherapy vs non-immunotherapy were 0.73 (95%CI 0.58–0.91) for males and 0.74 (95%CI 0.37–1.48) for females. In non-squamous NSCLC, the pooled HRs comparing immunotherapy versus non-immunotherapy were 0.62 (95%CI 0.71–0.94) for males and 0.59 (95%CI 0.39–0.89) for females. Compared to chemotherapy, immunotherapy can improve the prognosis of patients with advanced NSCLC. Meanwhile, there are sex differences in the efficacy of immunotherapy.KEY MESSAGECompared to chemotherapy, immunotherapy can improve the prognosis of patients with advanced NSCLC.The most interesting thing in this study is that immunotherapy showed significant sex differences in the treatment of squamous NSCLC. Compared to chemotherapy, immunotherapy can improve the prognosis of patients with advanced NSCLC. The most interesting thing in this study is that immunotherapy showed significant sex differences in the treatment of squamous NSCLC.
DOI: 10.6084/m9.figshare.21173887.v1
title: Sex difference in response to non-small cell lung cancer immunotherapy: an updated meta-analysis

description: Studying sex differences in the efficacy of immunotherapy may contribute to the practice of the precision medicine, especially in non-small cell lung cancer (NSCLC), a kind of cancer with sexual bimorphism. Published randomized controlled trials (RCTs), published by PubMed, Medline, Embase, and Scopus, before 15 June 2022, testing immunotherapy (CTLA-4 or PD-1/L1 inhibitor alone, combination or with chemotherapy) versus non-immunotherapy (receiving chemotherapy or placebo only) were included to assess different efficacy between males and females. The primary endpoint was overall survival (OS). This meta-analysis was registered with PROSPERO (CRD42022298439). Sixteen RCTs, involving 10,155 patients with advanced NSCLC, was collected in this meta-analysis. The pooled HR comparing immunotherapy vs non-immunotherapy were 0.76 (95%CI 0.71–0.81) for males and 0.74 (95%CI 0.63–0.87) for females. The pooled HRs comparing immune-checkpoint inhibitors (ICIs) plus chemotherapy versus chemotherapy were 0.79 (95%CI 0.70–0.89) for males and 0.63 (95%CI 0.42–0.92) for females. The pooled HRs comparing ICIs versus chemotherapy were 0.74 (95%CI 0.67–0.81) for males and 0.83 (95%CI 0.73–0.95) for females. In squamous NSCLC, the pooled HRs comparing immunotherapy vs non-immunotherapy were 0.73 (95%CI 0.58–0.91) for males and 0.74 (95%CI 0.37–1.48) for females. In non-squamous NSCLC, the pooled HRs comparing immunotherapy versus non-immunotherapy were 0.62 (95%CI 0.71–0.94) for males and 0.59 (95%CI 0.39–0.89) for females. Compared to chemotherapy, immunotherapy can improve the prognosis of patients with advanced NSCLC. Meanwhile, there are sex differences in the efficacy of immunotherapy.KEY MESSAGECompared to chemotherapy, immunotherapy can improve the prognosis of patients with advanced NSCLC.The most interesting thing in this study is that immunotherapy showed significant sex differences in the treatment of squamous NSCLC. Compared to chemotherapy, immunotherapy can improve the prognosis of patients with advanced NSCLC. The most interesting thing in this study is that immunotherapy showed significant sex differences in the treatment of squamous NSCLC.
DOI: 10.5061/dryad.fh347
title: Data from: A global analysis of plant recovery performance from water stress

description: Plant post-drought recovery performance is essential to predict shifts in
 ecosystem dynamics and production during frequent climate change-driven
 drought events. Yet, it is not clear how post-drought recovery is related
 to evolutionary and geographic variations in plants. In this study, we
 generated a global data set of post-drought recovery performance in 140
 plant species from published studies. We quantified the plant post-drought
 recovery performance by calculating a recovery index for multiple plant
 physiological and hydraulic parameters, including leaf water potential,
 net photosynthetic rate, leaf hydraulic conductance, and shoot biomass.
 The magnitude of recovery among four plant functional types (deciduous
 angiosperms, evergreen angiosperms, gymnosperms, and crops), two plant
 growth forms (shrubs and trees), two water management strategies
 (isohydric and anisohydric), four xylem porosity types (diffuse, ring,
 semi-ring, and tracheid), and four major biomes (dry sclerophyll forest,
 boreal forest, temperate forest, and tropical/subtropical forest) were
 compared. We found the inability to completely recover immediately after
 severe water stress is ubiquitous across all plant functional types and
 growth forms, while the rate and magnitude of post-drought recovery varied
 greatly across different plant taxonomic categories and geographic ranges.
 In general, plant hydraulic architecture, leaf anatomy and physiology
 affect plants’ propensity towards recovery, and reflect evolutionary
 consequences of plant adaptation to their habitat. Due to the essential
 role of plant functional traits in regulating carbon storage in each
 biome, a better understanding plant post-drought recovery performance
 could improve our predictions on ecosystem productivity in a rapidly
 changing climate.
description: Data_DroughtRecoveryPerformance_YinBauerle_2017
DOI: 10.6084/m9.figshare.20318611
title: A prospective randomized clinical trial of active-fluidics versus gravity-fluidics system in phacoemulsification for age-related cataract (AGSPC)

description: To figure out the efficacy, effects, safety and patient’s subjective perceptions of phacoemulsification with the active-fluidics system (AFS). This was a prospective, randomized, double-masked, controlled clinical study. Age-related cataract patients were recruited and randomly assigned to the AFS group and gravity-fluidics system (GFS) group in a ratio of 1:1 to have phacoemulsification. Participants were followed up at one day, one week, one month and three months postoperatively (Chinese Clinical Trial Registry, ChiCTR2100044409). The overall included participants were 107 finally. The total aspiration time of the AFS group was significantly less than that of the GFS group (<i>p</i> = .020), while no significant difference existed in cumulative dissipated energy and estimated fluid usage between the two groups. The best corrected visual acuity was significantly better in the AFS group at one day and one week postoperatively (<i>p</i> = .002, <i>p</i> = .038 respectively). The recovery of central corneal thickening and macular superficial vasculature increase was earlier in the AFS group. The central retinal thickness was significantly higher in the GFS group at one month and three months postoperatively (<i>p</i> = .029, <i>p</i> = .016 respectively). The incidence of corneal adverse events was higher in GFS group (<i>p</i> = .035). No serious adverse events occurred in either group. Pain scores and the scores of Cat-PROM5 questionnaire of the AFS group were significantly lower than that of the GFS group (<i>p</i> = .011, <i>p</i> = .002 respectively). AFS improves the efficiency, effects, safety and patients’ subjective perceptions of phacoemulsification compared with GFS. It is worthwhile to promote its application in cataract surgery.KEY MESSAGESThe active-fluidics system automatically detects and maintains stable intraocular pressure at the set value.The active-fluidics system improves the efficiency, effects, safety and patients’ subjective perceptions in phacoemulsification. The active-fluidics system automatically detects and maintains stable intraocular pressure at the set value. The active-fluidics system improves the efficiency, effects, safety and patients’ subjective perceptions in phacoemulsification.
DOI: 10.6084/m9.figshare.20318611.v1
title: A prospective randomized clinical trial of active-fluidics versus gravity-fluidics system in phacoemulsification for age-related cataract (AGSPC)

description: To figure out the efficacy, effects, safety and patient’s subjective perceptions of phacoemulsification with the active-fluidics system (AFS). This was a prospective, randomized, double-masked, controlled clinical study. Age-related cataract patients were recruited and randomly assigned to the AFS group and gravity-fluidics system (GFS) group in a ratio of 1:1 to have phacoemulsification. Participants were followed up at one day, one week, one month and three months postoperatively (Chinese Clinical Trial Registry, ChiCTR2100044409). The overall included participants were 107 finally. The total aspiration time of the AFS group was significantly less than that of the GFS group (<i>p</i> = .020), while no significant difference existed in cumulative dissipated energy and estimated fluid usage between the two groups. The best corrected visual acuity was significantly better in the AFS group at one day and one week postoperatively (<i>p</i> = .002, <i>p</i> = .038 respectively). The recovery of central corneal thickening and macular superficial vasculature increase was earlier in the AFS group. The central retinal thickness was significantly higher in the GFS group at one month and three months postoperatively (<i>p</i> = .029, <i>p</i> = .016 respectively). The incidence of corneal adverse events was higher in GFS group (<i>p</i> = .035). No serious adverse events occurred in either group. Pain scores and the scores of Cat-PROM5 questionnaire of the AFS group were significantly lower than that of the GFS group (<i>p</i> = .011, <i>p</i> = .002 respectively). AFS improves the efficiency, effects, safety and patients’ subjective perceptions of phacoemulsification compared with GFS. It is worthwhile to promote its application in cataract surgery.KEY MESSAGESThe active-fluidics system automatically detects and maintains stable intraocular pressure at the set value.The active-fluidics system improves the efficiency, effects, safety and patients’ subjective perceptions in phacoemulsification. The active-fluidics system automatically detects and maintains stable intraocular pressure at the set value. The active-fluidics system improves the efficiency, effects, safety and patients’ subjective perceptions in phacoemulsification.
DOI: 10.5061/dryad.nr2m3
title: Data from: Sex-dependent expression and fitness consequences of sunlight-derived color phenotypes

description: To understand whether early phenotypes are adaptive, knowledge of the
 environmental factors involved in their variation and the derived benefits
 from their expression is needed. Temperature and sunlight are considered
 two major selective forces influencing phenotypic coloration of birds at a
 global scale. However, within-population color adaptations in response to
 sunlight-temperature variation have been scarcely investigated and their
 acclimatization capacity is currently unknown. In addition, the sexes
 differ in their sensitivity to environmental factors during growth. This
 study evaluates how melanin plumage coloration varies in relation to sex
 and sunlight exposure in developing griffon vultures Gyps fulvus, and how
 this correlates with survival. The results show that individuals growing
 in nests more exposed to sunlight developed paler plumages as predicted by
 the thermal melanism hypothesis. In addition, paler males, but not
 females, have lower survival probability. Finally, a significant sexual
 dichromatism in fledgling plumage was observed, with females being paler
 than males. These results reveal within-population color variation related
 to sunlight-temperature conditions, probably as a capacity for local
 acclimatization through color plasticity and also provide evidence of sex
 differences in fitness optima for this trait under ecological pressures.
description: Griffon vulture
 coloration and nest sunlight exposureFour excel sheets: 1.
 Variables: variable descriptions. 2.Exposure-color: general database. 3.
 Melanin-color: melanin and color data of feathers. 4. Reflectance:
 reflectance spectra of light for mean values of visual color scores
 (Figure S1).AmNat.VultureColoration.xlsx
DOI: 10.5061/dryad.26th0
title: Data from: Selection for costly sexual traits results in a vacant mating niche and male dimorphism

description: The expected strong directional selection for traits that increase a
 male's mating ability conflicts with the frequent observation that
 within species, males may show extreme variation in sexual traits. These
 male reproductive polymorphisms are usually attributed to direct male-male
 competition. It is currently unclear, however, how directional selection
 for sexually selected traits may convert into disruptive selection, and if
 female preference for elaborate traits may be an alternative mechanism
 driving the evolution of male polymorphism. Here we explore this mechanism
 using the polyandric dwarf spider Oedothorax gibbosus as a model. We first
 show that males characterized by conspicuous cephalic structures serving
 as a nuptial feeding device (‘gibbosus males’) significantly outperform
 other males in siring offspring of previously fertilized females. However,
 significant costs in terms of development time of gibbosus males open a
 mating niche for an alternative male type lacking expensive secondary
 sexual traits. These ‘tuberosus males’ obtain virtually all fertilizations
 early in the breeding season. Individual-based simulations demonstrate a
 hitherto unknown general principle, by which males selected for high
 investment to attract females suffer constrained mating opportunities.
 This creates a vacant mating niche of unmated females for non-investing
 males and, consequently, disruptive selection on male secondary sexual
 traits.
description: Data mating
 experimentRaw data of the mating
 experiment. First sheet present the data of a single male exposure
 (corresponding to left panel of Fig. 3), second sheet multiple male
 exposure (corresponding to right panel Fig. 3). Column 1 and 2 describe
 the morph type of the respectively first and second male to which a female
 was mated (t = tuberosus, g = gibbosus). "ncop" = number of
 copulations in a session; "cop" = binary variable describing if
 a copulation took place (1 = yes; 0 = no).Mating
 experiment.xlsxPhenological
 dataRaw data presented in
 Fig. 4. ('nfem' = total number of females (mated and unmated);
 'n unmated fem' = number of unmated females; n tub = number of
 tuberosus males; n gib = number of gibbosus males; n juv = number of
 immature individuals)Phenology.xlsxSperm competition dataSperm competition data ('exp' = Experimental series, with FS representing fertile male -sterile male sequence and SF representing sterile male - fertile male sequence). ID is a unique identifier of each female. 'n1st' are the number of offspring sired by the first male (i.e. fertile in FS and sterile in SF). 'n2nd' are the number of offspring sired by the second male (i.e. sterile in FS and fertile in SF)Sperm competition.xlsx