cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.19977698
title: Age-dependent expression of Pten and Smad4 genes in the urogenital system of Wistar rats

description: PURPOSE: To analyze Pten and Smad4 gene expression in the urogenital system of Wistar rats in differents ages. METHODS: Pten and Smad4 mRNA expression was assessed in the bladder, ventral prostate, testis, ovaries, and uterus by real-time PCR. Statistical analysis using the ANOVA (p&lt;0.05). RESULTS: Pten levels showed a progressive age-dependent increase in the bladder (male and female) and prostate and were elevated in the ovaries of the middle-aged. In the uterus, no statistically significant differences were observed; in the testis, increased and decreased levels were seen in young adult and middle-aged rats, respectively. Smad4 expression was downregulated in the ovaries of the pubertal group but increased in the middle age group. In the uterus, Smad4 expression in the oldest group was higher than the others groups. In the testis, Smad4 expression steadily declined with age; in the prostate, it was higher in middle-aged rats than in younger rats. A similar trend was observed in the bladder of male and female middle-aged rats, compared with the pubertal group. CONCLUSION: The changes in phosphatase tensin homologue and Smad4 mRNA expression in Wistar rats appear to be associated with hormonal modifications in puberty and may be related to early follicular and testicular development.
DOI: 10.6084/m9.figshare.19977710
title: The investigation of airway management capacity of v-gel and cobra-PLA in anaesthetised rabbits

description: PURPOSE:To evaluate the applicability and airway management capacity of v-gel(r) and Cobra PLA in rabbit anaesthesia during assisted (AV) or controlled ventilation (CV).METHODS:This study was carried out in 44 adult New Zealand white rabbit. Baseline arterial pH, PaCO2 and PaO2 values were recorded. Anaesthesia was induced with 5 mg/kg xylasine and 35 mg/kg ketamine HCI combination. AV rabbits were assigned as; control (CG-AV; n=5), LMA (LMA-AV; n=5), cobra PLA (PLA-AV; n=5) and v-gel (v-gelAV; n=5). Rabbits have CV were also assigned as; ET (ET-CV; n=6), LMA (LMA-CV; n=6), cobraPLA (PLA-CV; n=6) and v-gel (v-gelCV; n=6). All measurements were repeated 1st, 5th, 15th and 30th mins during anaesthesia.RESULTS: The less insertion time, number of attempt and complications are recorded in v-gel applied rabbits compared to other apparatus. For arterial pH values significant differences are recorded in especially at 15th and 30th min between groups of CV (p&lt;0.005 or p&lt;0.001). All groups had similar results with each other during anaesthesia for PaCO2 except for LMA-CV group.CONCLUSION:The v-gel may be used as airway device in rabbit anaesthesia undergoing AV or CV and also can be a suitable alternative to endotracheal tubes and laryngeal mask airway.
DOI: 10.6084/m9.figshare.19977710.v1
title: The investigation of airway management capacity of v-gel and cobra-PLA in anaesthetised rabbits

description: PURPOSE:To evaluate the applicability and airway management capacity of v-gel(r) and Cobra PLA in rabbit anaesthesia during assisted (AV) or controlled ventilation (CV).METHODS:This study was carried out in 44 adult New Zealand white rabbit. Baseline arterial pH, PaCO2 and PaO2 values were recorded. Anaesthesia was induced with 5 mg/kg xylasine and 35 mg/kg ketamine HCI combination. AV rabbits were assigned as; control (CG-AV; n=5), LMA (LMA-AV; n=5), cobra PLA (PLA-AV; n=5) and v-gel (v-gelAV; n=5). Rabbits have CV were also assigned as; ET (ET-CV; n=6), LMA (LMA-CV; n=6), cobraPLA (PLA-CV; n=6) and v-gel (v-gelCV; n=6). All measurements were repeated 1st, 5th, 15th and 30th mins during anaesthesia.RESULTS: The less insertion time, number of attempt and complications are recorded in v-gel applied rabbits compared to other apparatus. For arterial pH values significant differences are recorded in especially at 15th and 30th min between groups of CV (p&lt;0.005 or p&lt;0.001). All groups had similar results with each other during anaesthesia for PaCO2 except for LMA-CV group.CONCLUSION:The v-gel may be used as airway device in rabbit anaesthesia undergoing AV or CV and also can be a suitable alternative to endotracheal tubes and laryngeal mask airway.
DOI: 10.25835/nop77eg4
title: Contributions Similarity in the Open Research Knowledge Graph

description: This evaluation set has been created for evaluating a content-based recommender system in the context of the Open Research Knowledge Graph (ORKG). The recommender system accepts structured ORKG contribution as input and recommends existing contributions in the ORKG semantically relevant to the given one. The evaluation set is manually annotated based on the featured comparisons in the ORKG. In the course of this, it has been distinguished between homogeneous (those who are dissimilar in 2-3 properties) and heterogeneous (otherwise) instances. Multiple annotations have been obtained for the former and exactly one for the latter. It has been also distinguished between "with_response" and "without_response" instances (50 instances for each). The former are those contributions for them the initial version of the contributions similarity service has found similarities and the latter are the opposite case. This evaluation set has been created and applied on a modified version of the contributions similarity service in the context of this master's thesis. The modified version of the service has simplified the document representation of contributions that are stored in an ElasticSearch index by omitting redundant terms.
DOI: 10.5281/zenodo.6598186
title: Insights to HIV-1 coreceptor usage by estimating HLA adaptation with Bayesian generalized linear mixed models

description: This is the data repository to the manuscript "Insights to HIV-1 coreceptor usage by estimating HLA adaptation with Bayesian generalized linear mixed models".<br> It contains a minimal data set to reproduce all results that don't compromise the privacy concerns.<br> The repository contains the following data: adaptscore_acute.csv A csv file that contains the estimated adaptation scores for the acute data set with HLA I model. adaptscore_leftout.csv A csv file that contains the estimated adaptation scores for the leftout data set with the joint HLA I and HLA II model adaptscore_training.csv A csv file that contains the estimated adaptation scores for the traininig data set with the joint HLA I and HLA II model adaptscore_training_hla1_without_clin.csv A csv file that contains the estimated adaptation scores for the training data set with the HLA I model (via cross-validation) adaptscore_training_seed2.csv A csv file that contains the estimated adaptation scores for the training data set with the joint HLA I and HLA II model via cross-validation with another seed env_leftout.fasta A fasta file that contains the consensus nucleotide sequences for the env protein for the leftout data set env_nt_274.fasta A fasta file that contains the consensus nucleotide sequences for the env protein for the training data set gag_leftout.fasta A fasta file that contains the consensus nucleotide sequences for the gag protein for the leftout data set gag_nt_274.fasta A fasta file that contains the consensus nucleotide sequences for the gag protein for the training data set
DOI: 10.6084/m9.figshare.19977800.v1
title: Early postoperative recovery after intracranial surgical procedures. Comparison of the effects of sevoflurane and desflurane

description: ABSTRACT PURPOSE: To compared the effects of sevoflurane and desflurane on early anesthesia recovery in patients undergoing to craniotomy for intracranial lesions. METHODS: After IRB approval, the study included 50 patients aged 18-70 years who had ASA physical statuses of I-II and were scheduled for intracranial surgery. Patients were randomly divided into two groups: sevoflurane and desflurane. Anaesthesia was routinely induced in all patients followed by desflurane 5%-6% or sevoflurane 1%-2%. Moreover remifentanil infusion (0.05-0.2 mcg/kg/min) was adjusted to maintain mean arterial pressure (MAP) within 20% baseline and heart rate &lt;90 bpm. Postoperatively, patients were evaluated over time for responses to painful stimulus, eye opening, hand squeezing, extubation, orientation and time required to achieve a Modified Aldrete Score of 9-10. Parametric and non-parametric data were assessed using Student's t- and Mann-Whitney U tests, respectively. A p&lt;0.05 was taken as statistically significant. RESULTS: The times to responses to painful stimuli (7.7±2.7 vs. 4.8±1.7 min.; p&lt;0.001), emergence (9.5±2.81 vs. 6.3±2.2 min.; p&lt;0.001), hand-squeezing (12.1±2.9 vs. 8.2±2.3 min.; p&lt;0.001), extubation (10.1±2.87 vs. 7.1±1.6 min.; p&lt;0.001), orientation (15.3±3.2 vs. 10.3±2.7 min.; p&lt;0.001) and Aldrete score of 9-10 (23.3±6.1 vs. 15.8±3.8 min.; p&lt;0.001) were significantly lower with desflurane-based anaesthesia vs. sevoflurane-based anaesthesia. CONCLUSION: Desflurane yields early recovery functions and facilitates early postoperative neurologic examinations of intracranial surgery patients.
DOI: 10.6084/m9.figshare.19977800
title: Early postoperative recovery after intracranial surgical procedures. Comparison of the effects of sevoflurane and desflurane

description: ABSTRACT PURPOSE: To compared the effects of sevoflurane and desflurane on early anesthesia recovery in patients undergoing to craniotomy for intracranial lesions. METHODS: After IRB approval, the study included 50 patients aged 18-70 years who had ASA physical statuses of I-II and were scheduled for intracranial surgery. Patients were randomly divided into two groups: sevoflurane and desflurane. Anaesthesia was routinely induced in all patients followed by desflurane 5%-6% or sevoflurane 1%-2%. Moreover remifentanil infusion (0.05-0.2 mcg/kg/min) was adjusted to maintain mean arterial pressure (MAP) within 20% baseline and heart rate &lt;90 bpm. Postoperatively, patients were evaluated over time for responses to painful stimulus, eye opening, hand squeezing, extubation, orientation and time required to achieve a Modified Aldrete Score of 9-10. Parametric and non-parametric data were assessed using Student's t- and Mann-Whitney U tests, respectively. A p&lt;0.05 was taken as statistically significant. RESULTS: The times to responses to painful stimuli (7.7±2.7 vs. 4.8±1.7 min.; p&lt;0.001), emergence (9.5±2.81 vs. 6.3±2.2 min.; p&lt;0.001), hand-squeezing (12.1±2.9 vs. 8.2±2.3 min.; p&lt;0.001), extubation (10.1±2.87 vs. 7.1±1.6 min.; p&lt;0.001), orientation (15.3±3.2 vs. 10.3±2.7 min.; p&lt;0.001) and Aldrete score of 9-10 (23.3±6.1 vs. 15.8±3.8 min.; p&lt;0.001) were significantly lower with desflurane-based anaesthesia vs. sevoflurane-based anaesthesia. CONCLUSION: Desflurane yields early recovery functions and facilitates early postoperative neurologic examinations of intracranial surgery patients.
DOI: 10.6084/m9.figshare.19977802
title: Publication rate of abstracts presented in a Brazilian experimental surgery congress

description: ABSTRACT PURPOSE: To verify the publication rate of the abstracts presented at the XII Brazilian Congress of Experimental Surgery. METHODS: We performed a cross-sectional study that evaluated if the abstracts accepted for presentation at the XII Brazilian Congress of Experimental Surgery were published in periodics. The information was acquired using the Scielo, Medline / Pubmed, LILACS and Google Scholar databases. RESULTS: From all the abstracts presented, only 77 (40.52%) were published in scientific journals. Of this total, 14 (18.18%) were published prior to the conference 35 (45.45%) in the same year that occurred congress, 56 (72.72%) in the period 2011-2013 and 63 (81, 81%) between the Congress and the year 2015. Regarding the geographical distribution of summaries, 42 (22%) were from the northern region, 19 (10%) from the Northeast, 8 (4%) Midwest, 116 (61%) from the Southeast and 5 (3%) from the south. CONCLUSION: The publication rate of the abstracts presented at the XII Brazilian Congress of Experimental Surgery was 40,52%, most from the state of Sao Paulo.
DOI: 10.6084/m9.figshare.19977802.v1
title: Publication rate of abstracts presented in a Brazilian experimental surgery congress

description: ABSTRACT PURPOSE: To verify the publication rate of the abstracts presented at the XII Brazilian Congress of Experimental Surgery. METHODS: We performed a cross-sectional study that evaluated if the abstracts accepted for presentation at the XII Brazilian Congress of Experimental Surgery were published in periodics. The information was acquired using the Scielo, Medline / Pubmed, LILACS and Google Scholar databases. RESULTS: From all the abstracts presented, only 77 (40.52%) were published in scientific journals. Of this total, 14 (18.18%) were published prior to the conference 35 (45.45%) in the same year that occurred congress, 56 (72.72%) in the period 2011-2013 and 63 (81, 81%) between the Congress and the year 2015. Regarding the geographical distribution of summaries, 42 (22%) were from the northern region, 19 (10%) from the Northeast, 8 (4%) Midwest, 116 (61%) from the Southeast and 5 (3%) from the south. CONCLUSION: The publication rate of the abstracts presented at the XII Brazilian Congress of Experimental Surgery was 40,52%, most from the state of Sao Paulo.
DOI: 10.34740/kaggle/dsv/3739215
title: WallStreetBets 2022
DOI: 10.15151/esrf-es-788651229
title: Rational Design of Inhibitors of Poxviral RNA Polymerase

description: Poxviruses are large cytosolic DNA viruses with a propensity to cause zoonoses. They are present in animal reservoirs and responsible for a large spectrum of disorders, including human smallpox. Only few causative treatment options are available, but vaccination with the non-pathogenic vaccinia virus enabled the eradication of the smallpox-causing variola virus. However, the herd immunity against poxviruses is dwindling in humans. Accordingly, poxviruses including monkeypox virus are considered as potentially highly threatening for their pandemic ‘spillover’ risk. Here, we strive to develop novel virostatics for the fight of poxviral dieases. Our approach is based on a set of atomic resolution cryo EM structures of vaccinia transcription complexes that we have recently determined. We use in silico screening to identify novel binders, test them in a radionuclide transcription assay for inhibition and will characterize the resulting ligand-RNA polymerase complexes by cryo EM.
DOI: 10.6084/m9.figshare.19663494
title: Supplementary Material for: Evaluation of the effects of vitrectomy with primary epiretinal membrane peel on optical quality using double-pass aberrometry

description: Introduction: We performed a prospective, single-center, cohort study in order to evaluate the effects of vitrectomy with epiretinal membrane (ERM) peel on optical quality in patients with primary ERM. Methods: Thirty patients treated for primary ERM by vitrectomy with ERM peel were included from our tertiary university hospital ophthalmology department. The main study outcome was variation in optical quality parameters measured using the HD Analyzer™ between pre-operative and two-month post-operative evaluations in operated eyes. Optical quality parameters comprised point spread function (PSF) width at 10% and 50%, objective scatter index (OSI), and modulation transfer function (MTF) cutoff. Contralateral non-operated eyes were used as an internal control for measurement reproducibility. Results: Mean PSF width at 10% (42.22 vs 27.37 arc/min; p = 0.0002) and mean OSI (3.32 vs 2.32; p = 0.0003) were significantly improved between pre- versus post-operative evaluations. Mean PSF width at 50% and mean MTF cutoff showed no changes. Subgroup analysis according to crystalline lens status gave similar results demonstrating that improvements in mean PSF width at 10% and OSI were not lens-related. Non-operated eyes showed no changes in any of the parameters analyzed. Conclusion: Reduced light scattering measured by OSI indicates improved optical quality following vitrectomy with ERM peel among patients with primary ERM. OSI measurement could thus be a new parameter of interest in the pre-operative assessment of primary ERM and other pre-vitrectomy assessments.
DOI: 10.6084/m9.figshare.19663494.v1
title: Supplementary Material for: Evaluation of the effects of vitrectomy with primary epiretinal membrane peel on optical quality using double-pass aberrometry

description: Introduction: We performed a prospective, single-center, cohort study in order to evaluate the effects of vitrectomy with epiretinal membrane (ERM) peel on optical quality in patients with primary ERM. Methods: Thirty patients treated for primary ERM by vitrectomy with ERM peel were included from our tertiary university hospital ophthalmology department. The main study outcome was variation in optical quality parameters measured using the HD Analyzer™ between pre-operative and two-month post-operative evaluations in operated eyes. Optical quality parameters comprised point spread function (PSF) width at 10% and 50%, objective scatter index (OSI), and modulation transfer function (MTF) cutoff. Contralateral non-operated eyes were used as an internal control for measurement reproducibility. Results: Mean PSF width at 10% (42.22 vs 27.37 arc/min; p = 0.0002) and mean OSI (3.32 vs 2.32; p = 0.0003) were significantly improved between pre- versus post-operative evaluations. Mean PSF width at 50% and mean MTF cutoff showed no changes. Subgroup analysis according to crystalline lens status gave similar results demonstrating that improvements in mean PSF width at 10% and OSI were not lens-related. Non-operated eyes showed no changes in any of the parameters analyzed. Conclusion: Reduced light scattering measured by OSI indicates improved optical quality following vitrectomy with ERM peel among patients with primary ERM. OSI measurement could thus be a new parameter of interest in the pre-operative assessment of primary ERM and other pre-vitrectomy assessments.
DOI: 10.5281/zenodo.4704593
title: Study Data: Obtaining Semi-Formal Models from Qualitative Data: From Interviews into BPMN Models in User-Centered Design Processes

description: This dataset (Data.zip) contains the raw data of a user study on the investigation of transforming think aloud interviews into BPMN models. All information on how to use the data are provide in the SPSS files and as a readme file. This transformation is executed following a manual additionally provided in Documents.zip. For the training phase, a website was used provided in Website.zip including Screenshots for simpler re-use. Further information are also included as readme file in the zip container. Main research question answered is in how far the manual reduces interpretation and variance in the created models.
DOI: 10.5281/zenodo.4704592
title: Study Data: Obtaining Semi-Formal Models from Qualitative Data: From Interviews into BPMN Models in User-Centered Design Processes

description: This dataset (Data.zip) contains the raw data of a user study on the investigation of transforming think aloud interviews into BPMN models. All information on how to use the data are provide in the SPSS files and as a readme file. This transformation is executed following a manual additionally provided in Documents.zip. For the training phase, a website was used provided in Website.zip including Screenshots for simpler re-use. Further information are also included as readme file in the zip container. Main research question answered is in how far the manual reduces interpretation and variance in the created models.
DOI: 10.5281/zenodo.6609895
title: rolling-stock-data

description: A collection of vehicle data for running time estimation in YAML format.
DOI: 10.5281/zenodo.6467448
title: rolling-stock-data

description: A collection of vehicle data for running time estimation in YAML format.
DOI: 10.5281/zenodo.6609904
title: Dataset fashion

description: The data contains consumer preferences and habits related to the purchase of second-hand clothes and clothes made from bio-based materials.
DOI: 10.5281/zenodo.6537442
title: Dataset fashion

description: The data contains consumer preferences and habits related to the purchase of second-hand clothes and clothes made from bio-based materials.
DOI: 10.34740/kaggle/dsv/3739289
title: AutoXGB
DOI: 10.6084/m9.figshare.19978001
title: Supplementary Material for: Das Beste aus zwei Welten: Eine systematische Übersicht zu Faktoren der Implementierung einer “Blended Therapy” (Gemischte Therapie) in der Psychotherapeutischen Routineversorgung

description: <b><i>Ziel:</i></b> Diese Arbeit gibt einen Überblick über bisherige wissenschaftliche Empfehlungen zur Implementierung der blended therapy, d.h. der Kombination von Therapien in Präsenz und via digitaler Medien. Die Empfehlungen um­fassen die Themen: (1) wahrgenommene Barrieren von Psychotherapeut*innen, (2) Format der blended therapy und (3) Indikationen für Patient*innen. In diesem Rahmen werden Faktoren aufgezeigt, die Akteur*innen im Gesundheitssystem als Orientierung dienen können, welche Determinanten bei der Implementierung in die Routineversorgung zu berücksichtigen sind. <b><i>Methodik:</i></b> Die systematische Suche erfolgte in den Datenbanken PsycArticles, PsycInfo, PSYNDEX und PubMed. <b><i>Ergebnisse:</i></b> Die Publikationen umfassen vier quantitative, neun qualitative sowie drei Mixed-Methods-Studien. Die bisherigen Arbeiten kommen zu dem Ergebnis, dass Psychotherapeut*innen frühzeitig in den Implementierungsprozess einbezogen und langfristige supportive Maßnahmen für die Umstrukturierung der bisherigen Arbeitsroutine geschaffen werden sollten. Das Format der blended therapy sollte nicht standardisiert angewandt, sondern vielmehr individuell an die Patient*innen angepasst werden. Hinsichtlich möglicher Indikationen werden verschiedene Einflussfaktoren der Patient*innen diskutiert, die bisher jedoch nur unzureichend untersucht wurden. <b><i>Diskussion:</i></b> Bisherige Studien weisen größtenteils homogene Charakteristika und Ergebnisse auf. Forschungslücken bestehen hinsichtlich der Frage, inwieweit sich die Ergebnisse auf andere Therapieschulen, Berufsgruppen und Störungsbilder übertragen lassen. <b><i>Schlussfolgerung:</i></b> Das Review veranschaulicht, dass es wichtiger Vorarbeit hinsichtlich der Anwendungsunterstützung für Psychotherapeut*innen sowie weiterer Forschungsaktivität bedarf, um die Implementierung von blended therapy im Sinne einer möglichen Verbesserung der psychotherapeutischen Versorgung voranzutreiben.