cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.15151/esrf-es-928404075
title: Danish Biochemistry and Structural biology BAG

description: This BAG application gathers many danish esrf users with the area of structural biochemistry (including both crystallography, cryoEM and SAXS). Some of the work focuses on carbohydrate active enzymes of all classes, with particular focus on biotechnological applications. Several PIs work in the important membrane proteins area, with both receptors and transporters as main focus, almost all potential or current drug targets. Other groups work on non membrane proteins which are also potential drug targets or in some way known to potentially be involved in disease - enzymes, bacterial antibiotic resistance and survival, DNA binding proteins and other regulators, immune system components. One crystallographic method development project is also included as are two principally bioSAXS projects. BioSAXS in addition contributes to several of the other projects, and infact we ask in this round for less Xtal beamtime and more bioSAXS beamtime.
DOI: 10.15151/esrf-es-937821464
title: Synthesis and single-crystal X-ray diffraction characterization of novel yttrium carbides under high pressure up to 200 GPa

description: The systematic investigation of transition metal carbides chemistry under high pressure will allow to produce new forms of polycarbon entities and to understand how their formation alter the physico-chemical properties. In our recent experiments at ID15b at ESRF (Experimental report CH-6139) we successfully synthesized new orthorhombic yttrium carbide, γ-Y4C5, with unusual arrangement of carbon atoms. Here, we propose further study of the Y-C system at pressures up to 200 GPa at ID27 beamline by single-crystal X-ray diffraction (SCXRD). The main aims of this proposal are i) synthesis of new Y-C compounds at multimegabar pressure, ii) characterization of their crystal structure in-situ by employing synchrotron single-crystal X-ray diffraction and compressional behavior in order to establish the produced compounds’ equation of state and find out if they are recoverable to atmospheric pressure.
DOI: 10.15151/esrf-es-942593514
title: In-situ high temperature investigation of series of the binary copper tellurides around Cu3-xTe2 composition

description: The proposed project complements our investigation on binary Cu3-xTe2 (x = 0-0.18) telluride, a synthetic analogue of naturally occurring mineral rickardite. While we recently published the physical properties results, the respective structural behavior of the investigation phase at relevant temperatures (from RT up to 733 K) remains undefined. The aim of this proposal is to investigate the structural behaviour of Cu3-xTe2 at high temperatures to establish the relationship between the structural changes and their effects observed during the examination of physical properties.
DOI: 10.6084/m9.figshare.21505747
title: Flora of Ceará, Brazil: Loranthaceae

description: Abstract This study provides a taxonomic treatment for the species of Loranthaceae in the state of Ceará, Northeastern Brazil. The survey was made based on the previous consultation of virtual herbaria, in loco visits, material loans, and photographs of diagnostic traits sent by herbarium curators. Morphological traits and geographic coordinates of all specimens collected in the State were recorded to prepare the distribution maps, identification key, and taxonomic descriptions for each taxon. A total of 184 specimens (discounting duplicates) from 30 herbaria were studied. Eight species are recorded for Ceará: Passovia pedunculata, Passovia pyrifolia, Psittacanthus cordatus, Psittacanthus dichroos, Psittacanthus eucalyptifolius, Struthanthus marginatus, Struthanthus polyrrhizus, and Struthanthus syringifolius. None are included in the IUCN Red List. However, four of them were collected inside protected areas (i.e., Passovia pedunculata, Psittacanthus cordatus, S. polyrrhizus, and S. syringifolius).
DOI: 10.6084/m9.figshare.21505747.v1
title: Flora of Ceará, Brazil: Loranthaceae

description: Abstract This study provides a taxonomic treatment for the species of Loranthaceae in the state of Ceará, Northeastern Brazil. The survey was made based on the previous consultation of virtual herbaria, in loco visits, material loans, and photographs of diagnostic traits sent by herbarium curators. Morphological traits and geographic coordinates of all specimens collected in the State were recorded to prepare the distribution maps, identification key, and taxonomic descriptions for each taxon. A total of 184 specimens (discounting duplicates) from 30 herbaria were studied. Eight species are recorded for Ceará: Passovia pedunculata, Passovia pyrifolia, Psittacanthus cordatus, Psittacanthus dichroos, Psittacanthus eucalyptifolius, Struthanthus marginatus, Struthanthus polyrrhizus, and Struthanthus syringifolius. None are included in the IUCN Red List. However, four of them were collected inside protected areas (i.e., Passovia pedunculata, Psittacanthus cordatus, S. polyrrhizus, and S. syringifolius).
DOI: 10.6084/m9.figshare.21505748
title: Flora of Rio de Janeiro: Chrysobalanaceae

description: Abstract This study comprehend the floristic treatment of Chrysobalanaceae from the state of Rio de Janeiro. Twenty-eight species, arranged into seven genera, are recorded. Two species, Licania arianeae and L. belemii, are herein first reported for the state. Descriptions, photographs, illustrations, identification keys, distribution maps and comments are provided based on fieldwork and analysis of herbarium specimens. Among the 92 municipalities in the state of Rio de Janeiro, three stand out for the diversity of Chrysobalanaceae (Rio de Janeiro, Mangaratiba and Petrópolis), while in 47 of them, there are no records of Chrysobalanaceae. The Metropolitan Region has the largest number of specimens collected, as opposed to the Northwestern Region with the smallest number.
DOI: 10.6084/m9.figshare.21505748.v1
title: Flora of Rio de Janeiro: Chrysobalanaceae

description: Abstract This study comprehend the floristic treatment of Chrysobalanaceae from the state of Rio de Janeiro. Twenty-eight species, arranged into seven genera, are recorded. Two species, Licania arianeae and L. belemii, are herein first reported for the state. Descriptions, photographs, illustrations, identification keys, distribution maps and comments are provided based on fieldwork and analysis of herbarium specimens. Among the 92 municipalities in the state of Rio de Janeiro, three stand out for the diversity of Chrysobalanaceae (Rio de Janeiro, Mangaratiba and Petrópolis), while in 47 of them, there are no records of Chrysobalanaceae. The Metropolitan Region has the largest number of specimens collected, as opposed to the Northwestern Region with the smallest number.
DOI: 10.6084/m9.figshare.21505750
title: IMPACT OF THE COVID-19 PANDEMIC ON THE SURGICAL TREATMENT OF SPINE PATHOLOGIES IN SUS

description: ABSTRACT Objective: To evaluate the impact of the COVID-19 pandemic on spine surgeries performed by SUS. To identify changes in surgical volume, as well as which procedures and regions of Brazil were most affected. To correlate such changes with literature data. Methods: A retrospective, descriptive study was conductedwith an analysis of the databases available to the public on the performance of spinal surgical procedures by SUS during the period from 2017 to 2021. The databases were created from variables of interest available in the SIH (Hospital Information System) of the SUS Information Technology Department website (DATASUS; http://datasus.saude.gov.br). The procedures were grouped according to type of surgery, topography, and access route for the construction of tables and statistical analysis. Results: In the years of the pandemic, a greater drop in surgical volume was observed, with a total of 13,276 procedures in 2020 and 12,158 in 2021, equivalent to -28.51% and -34.53%, respectively, of the average of the previous period. Conclusions: Given the paramount importance of attention to the fight against the pandemic, maintaining the level of assistance for spinal pathologies proved to be a great challenge, especially in relation to elective surgical pathologies that, when delayed too much, can seriously impact the quality of life and outcomes of future treatments. Level of Evidence: IV; Retrospective, descriptive.
DOI: 10.6084/m9.figshare.21505750.v1
title: IMPACT OF THE COVID-19 PANDEMIC ON THE SURGICAL TREATMENT OF SPINE PATHOLOGIES IN SUS

description: ABSTRACT Objective: To evaluate the impact of the COVID-19 pandemic on spine surgeries performed by SUS. To identify changes in surgical volume, as well as which procedures and regions of Brazil were most affected. To correlate such changes with literature data. Methods: A retrospective, descriptive study was conductedwith an analysis of the databases available to the public on the performance of spinal surgical procedures by SUS during the period from 2017 to 2021. The databases were created from variables of interest available in the SIH (Hospital Information System) of the SUS Information Technology Department website (DATASUS; http://datasus.saude.gov.br). The procedures were grouped according to type of surgery, topography, and access route for the construction of tables and statistical analysis. Results: In the years of the pandemic, a greater drop in surgical volume was observed, with a total of 13,276 procedures in 2020 and 12,158 in 2021, equivalent to -28.51% and -34.53%, respectively, of the average of the previous period. Conclusions: Given the paramount importance of attention to the fight against the pandemic, maintaining the level of assistance for spinal pathologies proved to be a great challenge, especially in relation to elective surgical pathologies that, when delayed too much, can seriously impact the quality of life and outcomes of future treatments. Level of Evidence: IV; Retrospective, descriptive.
DOI: 10.6084/m9.figshare.21505751
title: New multienzymatic complex formed between human cathepsin D and snake venom phospholipase A2

description: Abstract Background Cathepsin D (CatD) is a lysosomal proteolytic enzyme expressed in almost all tissues and organs. This protease is a multifunctional enzyme responsible for essential biological processes such as cell cycle regulation, differentiation, migration, tissue remodeling, neuronal growth, ovulation, and apoptosis. The overexpression and hypersecretion of CatD have been correlated with cancer aggressiveness and tumor progression, stimulating cancer cell proliferation, fibroblast growth, and angiogenesis. In addition, some studies report its participation in neurodegenerative diseases and inflammatory processes. In this regard, the search for new inhibitors from natural products could be an alternative against the harmful effects of this enzyme. Methods An investigation was carried out to analyze CatD interaction with snake venom toxins in an attempt to find inhibitory molecules. Interestingly, human CatD shows the ability to bind strongly to snake venom phospholipases A2 (svPLA2), forming a stable muti-enzymatic complex that maintains the catalytic activity of both CatD and PLA2. In addition, this complex remains active even under exposure to the specific inhibitor pepstatin A. Furthermore, the complex formation between CatD and svPLA2 was evidenced by surface plasmon resonance (SPR), two-dimensional electrophoresis, enzymatic assays, and extensive molecular docking and dynamics techniques. Conclusion The present study suggests the versatility of human CatD and svPLA2, showing that these enzymes can form a fully functional new enzymatic complex.
DOI: 10.6084/m9.figshare.21505751.v1
title: New multienzymatic complex formed between human cathepsin D and snake venom phospholipase A2

description: Abstract Background Cathepsin D (CatD) is a lysosomal proteolytic enzyme expressed in almost all tissues and organs. This protease is a multifunctional enzyme responsible for essential biological processes such as cell cycle regulation, differentiation, migration, tissue remodeling, neuronal growth, ovulation, and apoptosis. The overexpression and hypersecretion of CatD have been correlated with cancer aggressiveness and tumor progression, stimulating cancer cell proliferation, fibroblast growth, and angiogenesis. In addition, some studies report its participation in neurodegenerative diseases and inflammatory processes. In this regard, the search for new inhibitors from natural products could be an alternative against the harmful effects of this enzyme. Methods An investigation was carried out to analyze CatD interaction with snake venom toxins in an attempt to find inhibitory molecules. Interestingly, human CatD shows the ability to bind strongly to snake venom phospholipases A2 (svPLA2), forming a stable muti-enzymatic complex that maintains the catalytic activity of both CatD and PLA2. In addition, this complex remains active even under exposure to the specific inhibitor pepstatin A. Furthermore, the complex formation between CatD and svPLA2 was evidenced by surface plasmon resonance (SPR), two-dimensional electrophoresis, enzymatic assays, and extensive molecular docking and dynamics techniques. Conclusion The present study suggests the versatility of human CatD and svPLA2, showing that these enzymes can form a fully functional new enzymatic complex.
DOI: 10.6084/m9.figshare.21505753
title: Simultaneous unilateral central retinal vein occlusion and branch retinal artery occlusion after Coronavirus Disease 2019 (COVID-19) mRNA vaccine

description: ABSTRACT A 51-year-old non-obese woman presented with a one-week history of progressive blurry vision within the inferior visual field of her left eye. Her only relevant past medical history was long-standing hypothyroidism and recent vaccination against Coronavirus Disease 2019 (COVID-19) with an mRNA vaccine 12 days before the onset of symptoms. At examination, the anterior segment was unremarkable, but the retinal fundus revealed a central retinal vein occlusion associated with a branch retinal artery occlusion of the superior temporal branch in her left eye. Ancillary tests to rule out thrombophilia, hyperviscosity, hypercoagulability, or inflammation were negative. Ultrasound tests were also negative for a cardiac or carotid origin of the branch retinal artery occlusion. At two-month follow-up, no new retinal vascular occlusive events were observed. Although the best-corrected visual acuity at presentation was 8/10 in the left eye, the final best-corrected visual acuity remained 3/10.
DOI: 10.6084/m9.figshare.21505753.v1
title: Simultaneous unilateral central retinal vein occlusion and branch retinal artery occlusion after Coronavirus Disease 2019 (COVID-19) mRNA vaccine

description: ABSTRACT A 51-year-old non-obese woman presented with a one-week history of progressive blurry vision within the inferior visual field of her left eye. Her only relevant past medical history was long-standing hypothyroidism and recent vaccination against Coronavirus Disease 2019 (COVID-19) with an mRNA vaccine 12 days before the onset of symptoms. At examination, the anterior segment was unremarkable, but the retinal fundus revealed a central retinal vein occlusion associated with a branch retinal artery occlusion of the superior temporal branch in her left eye. Ancillary tests to rule out thrombophilia, hyperviscosity, hypercoagulability, or inflammation were negative. Ultrasound tests were also negative for a cardiac or carotid origin of the branch retinal artery occlusion. At two-month follow-up, no new retinal vascular occlusive events were observed. Although the best-corrected visual acuity at presentation was 8/10 in the left eye, the final best-corrected visual acuity remained 3/10.
DOI: 10.6084/m9.figshare.21505754
title: A novel agent for myeloma causing toxic keratopathy, belantamab mafodotin: a case report and literature review

description: ABSTRACT A 60-year-old-male with refractory relapsed multiple myeloma presented with redness, pain, foreign body sensation, and blurred vision in both eyes that gradually increased after his third belantamab mafotodin infusion. Biomicroscopy revealed bilateral microcyst-like epithelial changes and epithelial crystal-like deposits, whereas in vivo confocal microscopy revealed intraepithelial and subepithelial hyperreflective deposits in corneal epithelium. Belantamab mafodotin therapy was discontinued for seven weeks due to corneal toxicity, which cleared progressively. We aim to demonstrate belantamab mafodotin-related corneal toxicity that may be detected using slit lamp and in vivo confocal biomicroscopy.
DOI: 10.6084/m9.figshare.21505754.v1
title: A novel agent for myeloma causing toxic keratopathy, belantamab mafodotin: a case report and literature review

description: ABSTRACT A 60-year-old-male with refractory relapsed multiple myeloma presented with redness, pain, foreign body sensation, and blurred vision in both eyes that gradually increased after his third belantamab mafotodin infusion. Biomicroscopy revealed bilateral microcyst-like epithelial changes and epithelial crystal-like deposits, whereas in vivo confocal microscopy revealed intraepithelial and subepithelial hyperreflective deposits in corneal epithelium. Belantamab mafodotin therapy was discontinued for seven weeks due to corneal toxicity, which cleared progressively. We aim to demonstrate belantamab mafodotin-related corneal toxicity that may be detected using slit lamp and in vivo confocal biomicroscopy.
DOI: 10.5281/zenodo.3826554
title: Spanish abstracts from PubMed (machine-translated from English)

description: Spanish abstracts from PubMed (machine-translated from English) A state-of-the-art, domain-specific Neural Machine Translation system has been used to automatically translate a large number of articles (titles and abstracts) from PubMed, from English to Spanish. This dataset, in JSON format, provides MeSH terms and DeCS codes (if available), as well as other fields such as the year of publication for all articles. Copyright (c) 2020 Secretaría de Estado de Digitalización e Inteligencia Artificial
description: Funded by the Plan de Impulso de las Tecnologías del Lenguaje (Plan TL).
DOI: 10.5281/zenodo.3826553
title: Spanish abstracts from PubMed (machine-translated from English)

description: Spanish abstracts from PubMed (machine-translated from English) A state-of-the-art, domain-specific Neural Machine Translation system has been used to automatically translate a large number of articles (titles and abstracts) from PubMed, from English to Spanish. This dataset, in JSON format, provides MeSH terms and DeCS codes (if available), as well as other fields such as the year of publication for all articles. Copyright (c) 2020 Secretaría de Estado de Digitalización e Inteligencia Artificial
description: Funded by the Plan de Impulso de las Tecnologías del Lenguaje (Plan TL).
DOI: 10.6084/m9.figshare.21505756
title: The New Precarization of Work: a Conceptual Map

description: Abstract The new precarization of work, flexible precarization, presents changes and significant new elements within the context of precarious work. As a historical manifestation, it has gradually been included within structural-economic and institutional-political reforms. This paper aims to propose a conceptual map of the new precarization of work. The conceptual map is a critical tool for developing a scientific investigation and links concepts, context, and theoretical influences to promote the advancement of research in the field of the object studied. Three dimensions embodied the proposed map: the context, synthesized in the rise of neoliberalism, in the hegemony of the financial sector, in productive restructuring, and in economic globalization; flexible practices, in the condition of manifestations and causalities of the social arrangements, exposed in terms of the naturalization of unemployment, economic fatalism, the emptying of the State, the sanctity of contracts, deregulation, work intensification, the capture of savoir faire , decentralization and deterritorialization of productive units, technocratic manipulations, the weakening of the unions, part-time or temporary work, outsourcing, and despecialization; and the categories, relational expressions identified as flexible capitalism, flexible business, flexibility (flexible regulation), social precarization, and the movement from formal to real subsumption. Providing a synthesized image that seeks to critically apprehend the concreteness of the real, the map can be used as a script for new research and to contribute to critiques in the field of organizational studies.
DOI: 10.6084/m9.figshare.21505762
title: Clinical pharmaceutical services in primary health care of the Federal District: Performance frequency and conditioning factors

description: Abstract Pharmaceutical services correspond to a set of actions that aim to guarantee the integral access and rational use of drugs by the population. In this sense, this study aimed to identify the frequency and conditioning factors for clinical services of primary care in the Federal District, Brazil. A quantitative cross-sectional study was conducted, in which 34 pharmacists were interviewed. The most frequently developed clinical pharmaceutical services were dispensing, pharmaceutical guidance for users, and technical-pedagogical activities for the health team. There is a greater frequency of operation of clinical services by pharmacists working in pharmacies with physical infrastructure, with better levels of adequacy, greater support from management and health staff, and the inclusion in Family Health Support Nucleus activities. Although the clinical pharmaceutical services in primary care are incipient, the study raises important data for the reorientation and qualification of these actions.
DOI: 10.6084/m9.figshare.21505762.v1
title: Clinical pharmaceutical services in primary health care of the Federal District: Performance frequency and conditioning factors

description: Abstract Pharmaceutical services correspond to a set of actions that aim to guarantee the integral access and rational use of drugs by the population. In this sense, this study aimed to identify the frequency and conditioning factors for clinical services of primary care in the Federal District, Brazil. A quantitative cross-sectional study was conducted, in which 34 pharmacists were interviewed. The most frequently developed clinical pharmaceutical services were dispensing, pharmaceutical guidance for users, and technical-pedagogical activities for the health team. There is a greater frequency of operation of clinical services by pharmacists working in pharmacies with physical infrastructure, with better levels of adequacy, greater support from management and health staff, and the inclusion in Family Health Support Nucleus activities. Although the clinical pharmaceutical services in primary care are incipient, the study raises important data for the reorientation and qualification of these actions.
DOI: 10.6084/m9.figshare.21505765
title: Congenital ocular toxoplasmosis in consecutive siblings

description: ABSTRACT Toxoplasma gondii infection can cause ocular manifestations after acquired and congenital disease. We report two cases of symptomatic congenital toxoplasmosis with ocular involvement in non-twin siblings, with a 2-year interval between pregnancies. Vertical transmission of toxoplasmosis in successive pregnancies, which was once considered impossible, is now found to be plausible even in immunocompetent subjects.
DOI: 10.6084/m9.figshare.21505765.v1
title: Congenital ocular toxoplasmosis in consecutive siblings

description: ABSTRACT Toxoplasma gondii infection can cause ocular manifestations after acquired and congenital disease. We report two cases of symptomatic congenital toxoplasmosis with ocular involvement in non-twin siblings, with a 2-year interval between pregnancies. Vertical transmission of toxoplasmosis in successive pregnancies, which was once considered impossible, is now found to be plausible even in immunocompetent subjects.