cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.25345/c51v8g
title: MassIVE MSV000087975 - Effects of Probiotics supplementation on Immune Function and microbiota in neonatal calves infected by E. coli K99
title: Metaproteomic data were obtained from jejunal contents of Holstein calves in three treatment groups: 1) Control group (H group): fed a basal diet and not challenged with E. coli K99; 2) Diarrhea group (D group): fed a basal diet and orally challenged with E. coli K99 and antibiotic support therapy; 3) MSP group (Probiotics group, P group): orally challenged with E. coli K99; fed a basal diet supplemented daily with MSP per day according to our previous research (unpublished data).
DOI: 10.6084/m9.figshare.14844669
title: Dual agonist–antagonist effect of ulipristal acetate in human endometrium and myometrium

description: The aim of this study was to assess the molecular effect of ulipristal acetate (UPA) on gene expression in myometrium and endometrium of patients with symptomatic fibroids. Tissues isolated from four women treated preoperatively with UPA (5 mg) were compared to those from untreated controls using NanoString platform to assess the expression of 75 candidate genes modulated by UPA and ovarian steroids. Deregulated genes were then validated by real-time PCR. In myometrium, UPA exerted an antagonistic effect similar to that observed in fibroids. In UPA-treated endometrium, six genes were identified as highly and significantly upregulated, including matricellular genes <i>CCN1</i> (54-fold, <i>P</i> = 0.0018) and <i>CCN2</i> (11-fold, <i>P</i> = 0.00044), Krüppel-like factor 4 (&gt;3-fold, <i>P</i> = 0.0036), and mast cell markers including tryptases <i>TPSAB1/TPSB2</i> (31-fold, <i>P</i> = 0.023) and carboxypeptidase A (<i>CPA3</i>, 17-fold, <i>P</i> = 0.05). In endometrium, UPA induced the expression of genes involved in fibrogenesis and mast cell function—some of them being widely involved in hepatic injury, which could explain the marked fibrosis and inflammatory cell infiltration observed in explanted livers from patients under UPA treatment.
DOI: 10.6084/m9.figshare.14844669.v1
title: Dual agonist–antagonist effect of ulipristal acetate in human endometrium and myometrium

description: The aim of this study was to assess the molecular effect of ulipristal acetate (UPA) on gene expression in myometrium and endometrium of patients with symptomatic fibroids. Tissues isolated from four women treated preoperatively with UPA (5 mg) were compared to those from untreated controls using NanoString platform to assess the expression of 75 candidate genes modulated by UPA and ovarian steroids. Deregulated genes were then validated by real-time PCR. In myometrium, UPA exerted an antagonistic effect similar to that observed in fibroids. In UPA-treated endometrium, six genes were identified as highly and significantly upregulated, including matricellular genes <i>CCN1</i> (54-fold, <i>P</i> = 0.0018) and <i>CCN2</i> (11-fold, <i>P</i> = 0.00044), Krüppel-like factor 4 (&gt;3-fold, <i>P</i> = 0.0036), and mast cell markers including tryptases <i>TPSAB1/TPSB2</i> (31-fold, <i>P</i> = 0.023) and carboxypeptidase A (<i>CPA3</i>, 17-fold, <i>P</i> = 0.05). In endometrium, UPA induced the expression of genes involved in fibrogenesis and mast cell function—some of them being widely involved in hepatic injury, which could explain the marked fibrosis and inflammatory cell infiltration observed in explanted livers from patients under UPA treatment.
DOI: 10.3886/e147401
title: Replication "Valuing Life as an Asset, as a Statistic, and at Gunpoint"

description: This project provides the data sets to replicate the results of the paper "Valuing Life as an Asset, as Statistics, and at Gunpoint" of Hugonnier, Pelgrin, and Saint-Amour (2021). The paper can be summarized as follows.<br><br>Rationalizing the stark differences between the Human Capital (HK) and the StatisticalValues (VSL) of a human life is complicated by the absence of common foundations.We solve a human capital investment model with longevity risk to characterize the HK.The associated indirect utility yields the willingness to pay (WTP) against mortality; themarginal WTP solves the VSL. Indifference between life and certain death characterizesthe limiting WTP and provides a Gunpoint Value (GPV). A structural estimation revealssimilar HK (300 K$) and GPV (251 K$) and explains a much larger VSL (4.98 M$) by astrongly concave WTP.
description: We use a sample of 7949 U.S. individuals obtained from the 2017 wave of the Panel Study of Income Dynamics, (PSID, Institute of Social Research, 2020) and weighted with corresponding individual and family weights. We also use the same data from the 2009 (respectively, 2013) wave. .
DOI: 10.3886/e147401v1
title: Replication "Valuing Life as an Asset, as a Statistic, and at Gunpoint"

description: This project provides the data sets to replicate the results of the paper "Valuing Life as an Asset, as Statistics, and at Gunpoint" of Hugonnier, Pelgrin, and Saint-Amour (2021). The paper can be summarized as follows.<br><br>Rationalizing the stark differences between the Human Capital (HK) and the StatisticalValues (VSL) of a human life is complicated by the absence of common foundations.We solve a human capital investment model with longevity risk to characterize the HK.The associated indirect utility yields the willingness to pay (WTP) against mortality; themarginal WTP solves the VSL. Indifference between life and certain death characterizesthe limiting WTP and provides a Gunpoint Value (GPV). A structural estimation revealssimilar HK (300 K$) and GPV (251 K$) and explains a much larger VSL (4.98 M$) by astrongly concave WTP.
description: We use a sample of 7949 U.S. individuals obtained from the 2017 wave of the Panel Study of Income Dynamics, (PSID, Institute of Social Research, 2020) and weighted with corresponding individual and family weights. We also use the same data from the 2009 (respectively, 2013) wave. .
DOI: 10.6073/pasta/04c1a5d3f43d6a4eae68137c7238d561
title: Meiobenthos abundance. Long-term variability and dynamics of estuarine meiobenthic populations for North Inlet Estuary, South Carolina, from 1972 to 1992, North Inlet LTER (Reformatted to a Darwin Core Archive)

description: This data package is formatted as a Darwin Core Archive (DwC-A, event core). For more information on Darwin Core see https://www.tdwg.org/standards/dwc/. This Level 2 data package was derived from the Level 1 data package found here: https://pasta.lternet.edu/package/metadata/eml/edi/350/3, which was derived from the Level 0 data package found here: https://pasta.lternet.edu/package/metadata/eml/knb-lter-nin/6/1. The abstract below was extracted from the Level 0 data package and is included for context: The original purpose of this research was to determine if natural meiobenthic assemblages exhibited continuity over time and to monitor several physical variables to determine if these influenced long-term temporal patterns. The most recent study focused on variation and the relations of meiobenthos abundance with environmental factors over 11 years. Typically marine benthic community studies are limited temporally and the majority of previously published 'longterm' meiofauna results (all taxa) were based on about a year's duration.
DOI: 10.6073/pasta/b7c5a878c0df94170785ee1eeedbc1f8
title: Zooplankton Data for North Inlet Estuary, South Carolina, from 1981 to 1992, North Inlet LTER (Reformatted to a Darwin Core Archive)

description: This data package is formatted as a Darwin Core Archive (DwC-A, event core). For more information on Darwin Core see https://www.tdwg.org/standards/dwc/. This Level 2 data package was derived from the Level 1 data package found here: https://pasta.lternet.edu/package/metadata/eml/edi/352/2, which was derived from the Level 0 data package found here: https://pasta.lternet.edu/package/metadata/eml/knb-lter-nin/2/1. The abstract below was extracted from the Level 0 data package and is included for context: This data package consists of Zooplankton Data for North Inlet Estuary, South Carolina, from 1981 to 1992, North Inlet LTER. The purpose of the long term monitoring of zooplankton was to characterize the fauna in the water column larger than or equal to 153 microns and to obtain some basic information on each of the taxa encountered there. A sampling regime of collections made at regular biweekly intervals was implemented to provide the best quantitative assessment of long term changes in the zooplankton population dynamics.
DOI: 10.6084/m9.figshare.15156528
title: 20210601_MeSCN#319.zip

description: Full data from a measurement run using a Phasetech 2D-spectrometer powered by a HE Topas. The sample is MeSCN, an commonly used test sample with a rather long virbational lifetime.<br>
DOI: 10.6084/m9.figshare.15156528.v1
title: 20210601_MeSCN#319.zip

description: Full data from a measurement run using a Phasetech 2D-spectrometer powered by a HE Topas. The sample is MeSCN, an commonly used test sample with a rather long virbational lifetime.<br>
DOI: 10.5281/zenodo.5186547
title: ObstacleTrack-images

description: images and sources for the Obstacle track of segmentmeifyoucan.com
description: Robin Chan and Svenja Uhlemeyer acknowledge funding by the German Federal Ministry for Economic Affairs and Energy, within the projects "KI Absicherung", grant no. 19A19005R, and "KI Delta Learning", grant no. 19A19013Q, respectively. We thank the consortiums for the successful cooperation. We would also like to thank the "BUW-KI" team who substantially contributed to collecting and labeling of data.
DOI: 10.5281/zenodo.5186454
title: Argania spinosa SPAdes preassembly

description: .
DOI: 10.5281/zenodo.5186453
title: Argania spinosa SPAdes preassembly

description: .
DOI: 10.6084/m9.figshare.15156267
title: Supplementary Material for: Use of the HAVOC Score to Identify Patients at Highest Risk of Developing Atrial Fibrillation

description: <b><i>Background:</i></b> Recent studies using insertable cardiac monitors (ICMs) show a high incidence of atrial fibrillation (AF). Further identifying subsets of patients who could benefit most from ICMs is desirable. We evaluated whether the HAVOC risk score which predicts AF in patients with cryptogenic stroke also predicts AF detection by ICMs in those without recent stroke. <b><i>Methods:</i></b> Participants were included from the prospective, industry-sponsored REVEAL AF study assessing AF incidence in patients with CHADS<sub>2</sub> scores ≥3 or =2 with 1 or more additional AF risk factors, who had ICM data and were not receiving anti-arrhythmic drugs. Ischemic stroke occurring less than 1 year prior to enrollment or documented AF were exclusion criteria. AF was defined as an adjudicated ICM-detected episode ≥6 min in duration. HAVOC scores were calculated by assigning 4 points for congestive heart failure, 2 points for each of hypertension, age ≥75 years, valvular disease, and coronary artery disease, and 1 point for each of peripheral vascular disease and obesity (body mass index &gt;30). Scores classified risk as low (0–4), intermediate (5–9), or high (10–14); corresponding AF detection rates were compared using the log-rank test. AF incidence rates in patients with and without a history of remote stroke at baseline were also compared. <b><i>Results:</i></b> Among 391 participants, the mean age was 71.5 ± 9.8 years and 186 (47.6%) were women. In total, 130 (33.2%) developed AF over 18 months. Stratification by HAVOC risk score was: 95 (24%) low, 241 (62%) intermediate, and 55 (14%) high. At 18 months, AF incidence in patients with low HAVOC scores (19.5%) was lower than in those with intermediate (32.1%) or high (34.2%) scores. AF incidence was similar among those with (<i>n</i> = 78) versus without (<i>n</i> = 313) remote stroke (27.3% vs. 29.8%; median time from stroke to ICM insertion was 4.2 [2.2–8.2] years). <b><i>Conclusions:</i></b> The HAVOC risk score identified a subset of individuals at greatest risk of developing AF, while AF incidence rates were similar among those with and without remote stroke. The use of the HAVOC score could help identify those at greatest likelihood of manifesting AF during long-term monitoring.
DOI: 10.6084/m9.figshare.15156648
title: Supplementary Material for: Hyperoncotic Albumin Solution in Continuous Renal Replacement Therapy Patients

description: <b><i>Aim:</i></b> The aim of this study was to investigate the association of hyperoncotic (20%) human albumin solution (HAS) with outcomes among critically ill patients receiving continuous renal replacement therapy (RRT). <b><i>Methods:</i></b> Analysis of the Randomized Evaluation of Normal versus Augmented Level (RENAL) RRT trial data. <b><i>Results:</i></b> Of 1,508 patients, 771 (51%) received albumin. Of these, 345 (45%) received 4% HAS only, 155 (20%) received 20% HAS only, and 271 (35%) received both. Patients who received combined 4% and 20% HAS were more severely ill, received more days of RENAL trial therapy and required mechanical ventilation for longer. Mean daily fluid balance was −288 mL (−904 to 261) with 20% HAS only versus 245 mL (−248 to 1,050) with 4% HAS only (<i>p</i> &lt; 0.001). On Cox proportional hazards regression, 20% HAS exposure was not associated with greater 90-day mortality (odds ratio 1.12, 95% confidence interval [CI]: 0.77–1.62; <i>p</i> = 0.55) or longer recovery to RRT independence (sub-hazard ratio 1.04, 95% CI: 0.84–1.30; <i>p</i> = 0.70) compared to those who received 4% HAS only. <b><i>Conclusions:</i></b> RENAL trial patients commonly received albumin in varying concentrations. The administration of 20% HAS was associated with a more negative fluid balance but was not independently associated with increased mortality or RRT dependence when compared to 4% HAS only.
DOI: 10.5255/ukda-sn-855140
title: Perception of Professional Boundaries and Experiences of Misconduct among Different Demographic Groups Within Higher Education in the UK, 2017-2018

description: The data contain questions measuring: student perceptions of professional boundaries, experiences of misconduct by HE staff on students, gender and occupation of perpetrators, the effect of experiencing conduct, responses to misconduct, reporting behaviours and demographic questions.
DOI: 10.6084/m9.figshare.15156504
title: Supplementary Material for: Alteration of Allergen Fold of Bos d 5 into a Hypoallergenic Vaccine for Immunotherapy of Cow’s Milk Allergy

description: <b><i>Background:</i></b> Cow’s milk allergy (CMA) is the most common IgE-mediated food allergy and Bos d 5 is the major allergen in cow’s milk proteins. More than 60% of the patients with CMA are sensitized to this protein. <b><i>Methods and Results:</i></b> A recombinant protein, encoded by a synthetic gene and consisting of reassembled Bos d 5 fragments, was expressed in <i>E. coli</i> strain BL21 (DE3) cells and purified to homogeneity. The B5M lacked relevant IgE-reactivity and allergenic activity compared with Bos d 5 in dot-blot and basophil activation assays. T-cell proliferation experiments demonstrated that B5M preserved the main T cell epitopes of Bos d 5. Immunization of rabbits with B5M induced protective IgG antibodies that blocked the binding of patients’ IgE antibodies to the wild-type allergen and inhibited the degranulation of basophils induced by Bos d 5. <b><i>Conclusion:</i></b> Thus, we developed a new strategy, which was based on rational molecular reassembly for allergen-specific immunotherapy (AIT) of CMA and food allergy.
DOI: 10.6084/m9.figshare.14822382
title: Supplementary Material for: Inhibitory Effects of Chitosan on Sebum Production on Facial Skin

description: Medicine
DOI: 10.6084/m9.figshare.14822382.v1
title: Supplementary Material for: Inhibitory Effects of Chitosan on Sebum Production on Facial Skin

description: Medicine
DOI: 10.6084/m9.figshare.15156423
title: Supplementary Material for: Development of a Third Trimester Contingent Prognostic Prediction Scheme for Suspected Early-Onset Pre-Eclampsia

description: <b><i>Introduction:</i></b> Short-term prediction of pre-eclampsia (PE) using soluble FMS-like tyrosine kinase-1 (sFlt-1)/ placental growth factor (PlGF) ratio has high false-positive rate. Therefore, we developed a prognostic prediction tool that predicts early-onset PE leading to delivery within 1 week on pregnancies with an sFlt-1/PlGF ratio above 38 and compared it with an analogous model based on sFlt-1/PlGF ratio and with the 655 sFlt-1/PlGF ratio cutoff. <b><i>Methods:</i></b> Cohort study of 363 singleton pregnancies with clinical suspicion of PE before 34 weeks of gestation, allowing repeated assessments (522). 213 samples with an sFlt-1/PlGF ratio above 38 were assessed to construct and identify the best-fit linear mixed model. N-terminal pro-B-type natriuretic peptide (NT-proBNP), sFlt-1 MoM, PlGF MoM, and sFlt-1/PlGF ratio combined with gestational age (GA) were assessed. <b><i>Results:</i></b> None of the pregnancies with an sFlt-1/PlGF ratio of 38 or below developed early-onset PE (309 samples from 240 pregnancies). Conversely, 47 women of 213 assessments (22.1%) with an sFlt-1/PlGF ratio above 38 developed the assessed outcome. The selected model included sFlt-1 MoM, NT-proBNP, and GA. Differences in area under the curve were observed between the selected model and the GA + sFlt-1/PlGF model (<i>p</i> = 0.04). At an sFlt-1/PlGF ratio cutoff of 655, detection rate was 31.9% (15/47), while the selected model detection was 55.3% (26/47) (<i>p</i> = 0.008). <b><i>Discussion:</i></b> Considering repeated assessments, the sFlt-1/PlGF ratio of 38 or below adequately ruled out early-onset PE, leading to delivery within 1 week. However, when sFlt-1/PlGF ratio is above 38, the prediction tool derived from linear mixed model based on GA, NT-proBNP, and sFlt-1 MoM, provided a better prognosis prediction than the sFlt-1/PlGF ratio.
DOI: 10.6084/m9.figshare.15156423.v1
title: Supplementary Material for: Development of a Third Trimester Contingent Prognostic Prediction Scheme for Suspected Early-Onset Pre-Eclampsia

description: <b><i>Introduction:</i></b> Short-term prediction of pre-eclampsia (PE) using soluble FMS-like tyrosine kinase-1 (sFlt-1)/ placental growth factor (PlGF) ratio has high false-positive rate. Therefore, we developed a prognostic prediction tool that predicts early-onset PE leading to delivery within 1 week on pregnancies with an sFlt-1/PlGF ratio above 38 and compared it with an analogous model based on sFlt-1/PlGF ratio and with the 655 sFlt-1/PlGF ratio cutoff. <b><i>Methods:</i></b> Cohort study of 363 singleton pregnancies with clinical suspicion of PE before 34 weeks of gestation, allowing repeated assessments (522). 213 samples with an sFlt-1/PlGF ratio above 38 were assessed to construct and identify the best-fit linear mixed model. N-terminal pro-B-type natriuretic peptide (NT-proBNP), sFlt-1 MoM, PlGF MoM, and sFlt-1/PlGF ratio combined with gestational age (GA) were assessed. <b><i>Results:</i></b> None of the pregnancies with an sFlt-1/PlGF ratio of 38 or below developed early-onset PE (309 samples from 240 pregnancies). Conversely, 47 women of 213 assessments (22.1%) with an sFlt-1/PlGF ratio above 38 developed the assessed outcome. The selected model included sFlt-1 MoM, NT-proBNP, and GA. Differences in area under the curve were observed between the selected model and the GA + sFlt-1/PlGF model (<i>p</i> = 0.04). At an sFlt-1/PlGF ratio cutoff of 655, detection rate was 31.9% (15/47), while the selected model detection was 55.3% (26/47) (<i>p</i> = 0.008). <b><i>Discussion:</i></b> Considering repeated assessments, the sFlt-1/PlGF ratio of 38 or below adequately ruled out early-onset PE, leading to delivery within 1 week. However, when sFlt-1/PlGF ratio is above 38, the prediction tool derived from linear mixed model based on GA, NT-proBNP, and sFlt-1 MoM, provided a better prognosis prediction than the sFlt-1/PlGF ratio.
DOI: 10.5281/zenodo.5186715
title: Data Collection - Overturning in the Subpolar North Atlantic Program (OSNAP)

description: The data set is a collection of observations carried out under the framework of the Overturning in the Subpolar North Atlantic Program (OSNAP) international program, which is designed to provide continuous records of water hydrographic properties and currents in the subpolar North Atlantic. The data are logged by moored instruments and floats. The array of moored instruments is aligned along two transects / legs. The first one extends from the Labrador coast to the southwestern tip of Greenland across the mouth of the Labrador Sea (OSNAP West). The second transect is orientated from the southeastern tip of Greenland to Scotland (OSNAP East). Archived in this repository is the collection of moored data from the OSNAP West, which covers the periods 2014-2016, 2016-2018, 2018-2020. Five types of instruments were recovered from nine moorings: Microcats, Onsets, ADCPs, RCM-8 and RCM-11. The data have been quality-controlled and are stored in NetCDF data format. The nine moorings were deployed in different years at the four OSNAP sites on the Labrador shelf: K7, C1, C2 and C3. The collected data span the vertical range from 40 to 800 m. The coordinates, times and other essential metadata are stored in the attributes of the data files and the data inventory (file: OSNAP_Running_Log.xlsx). This repository includes static named branch releases which can be cited and pointed to by DOI along with the master branch that includes the latest updated content past the most recent named branch release.
description: Subject to Open Government Licence - Canada (http://open.canada.ca/en/open-government-licence-canada).
DOI: 10.6084/m9.figshare.15156348
title: Supplementary Material for: Safety and Efficacy of 2 Intracavernous Injections of Allogeneic Wharton’s Jelly-Derived Mesenchymal Stem Cells in Diabetic Patients with Erectile Dysfunction: Phase 1/2 Clinical Trial

description: <b><i>Background and Objectives:</i></b> Stem cell therapy is a novel treatment with regenerative ability that can treat erectile dysfunction (ED). This phase 1/2 clinical trial (NCT02945449) using 2 consecutive intracavernous (IC) injections of allogeneic Wharton’s jelly-derived mesenchymal stem cells (WJ-MSCs) was studied for the first time in the treatment of diabetic patients with ED. The primary outcome was to assess the safety and tolerability, and the secondary outcome was to assess the efficacy of 2 consecutive IC injections of allogeneic WJ-MSCs in diabetic ED. <b><i>Patients and Methods:</i></b> Twenty-two diabetic patients with refractory ED were included. Two consecutive IC injections of allogeneic WJ-MSCs were performed. Tolerability was assessed immediately, and at 24 h, safety was evaluated for 12 months. Efficacy was assessed using International Index of Erectile Function-5 (IIEF-5), Erection Hardness Score (EHS), and Color Duplex Doppler Ultrasound for 12 months. <b><i>Results:</i></b> The procedure was well-tolerated. Minimal and transient adverse events were redness and bruising at the site of injections. There were no patient-reported serious adverse effects. There were significant improvements in IIEF-5, EHS, peak systolic velocity (PSV) basal, and 20-min PSV, all over the follow-up time points in comparison to the baseline. <b><i>Conclusion:</i></b> This is the first human study with proven tolerability, safety, and efficacy of IC injections of allogeneic WJ-MSCs for the treatment of diabetic patients with ED.
DOI: 10.6084/m9.figshare.15156669
title: Initial Cenozoic magmatic activity in East Africa: New geochemical constraints on magma distribution within the Eocene continental flood basalt province

description: Table S2. Whole rock trace element compositions of Amaro and Gamo basalts
DOI: 10.6084/m9.figshare.15156669.v1
title: Initial Cenozoic magmatic activity in East Africa: New geochemical constraints on magma distribution within the Eocene continental flood basalt province

description: Table S2. Whole rock trace element compositions of Amaro and Gamo basalts