cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.11841486.v1
title: Practice variation on hospital level in the systemic treatment of metastatic colorectal cancer in The Netherlands: a population-based study

description: <b>Introduction:</b> Population-based data on the implementation of guidelines for cancer patients in daily practice are scarce, while practice variation may influence patient outcomes. Therefore, we evaluated treatment patterns and associated variables in the systemic treatment of metastatic colorectal cancer (mCRC) in the Netherlands. <b>Material and methods:</b> We selected a random sample of adult mCRC patients diagnosed from 2008 to 2015 from the National Cancer Registry in 20 (4 academic, 8 teaching and 8 regional) Dutch hospitals. We examined the influence of patient, demographic and tumour characteristics on the odds of being treated with systemic therapy according to the current guideline and assessed its association with survival. <b>Results:</b> Our study population consisted of 2222 mCRC patients of whom 1307 patients received systemic therapy for mCRC. Practice variation was most obvious in the use of bevacizumab and anti-EGFR therapy in patients with <i>(K)RAS</i> wild-type tumours. Administration rates did not differ between hospital types but fluctuated between individual hospitals for bevacizumab (8–92%; <i>p</i> p = .05). Bevacizumab administration was inversely correlated to higher age (OR:0.2; 95%CI: 0.1–0.3) comorbidity (OR:0.6; 95%CI: 0.5–0.8) and the presence of metachronous metastases (OR:0.5; 95%CI: 0.3–0.7), but patient characteristics did not differ between hospitals with low or high bevacizumab administration rates. The hazard ratios for exposure to bevacizumab and anti-EGFR therapy were 0.8 (95%CI: 0.7–0.9) and 0.6 (95%CI: 0.5–0.8), respectively. <b>Discussion:</b> We identified significant inter-hospital variation in targeted therapy administration for mCRC patients, which may affect outcome. Age and comorbidity were inversely correlated with non-administration of bevacizumab but did not explain inter-hospital practice variation. Our data suggest that practice variation is based on individual strategy of hospitals rather than guideline recommendations or patient-driven decisions. Individual hospital strategies are an additional factor that may explain the observed differences between real-life data and results obtained from clinical trials.
DOI: 10.6084/m9.figshare.11841462
title: Metadata record for: Longitudinal spatial dataset on travel times and distances by different travel modes in Helsinki Region

description: This dataset contains key characteristics about the data described in the Data Descriptor Longitudinal spatial dataset on travel times and distances by different travel modes in Helsinki Region. <br> Contents: <br> 1. human readable metadata summary table in CSV format 2. machine readable metadata file in JSON format <br> <br> Versioning Note:Version 2 was generated when the metadata format was updated from JSON to JSON-LD. This was an automatic process that changed only the format, not the contents, of the metadata.<br>
DOI: 10.6084/m9.figshare.11841468
title: ADDING-SOLAR-POWER-FOR-NET-ENERGY-ZERO-BUILDING.pdf

description: This paper deals with Building Energy Audit conducted at buildings located in a hilly region of West Bengal state and also provides the prospect of using solar energy to make all buildings achieve the status of Net Energy Zero Building. The study was conducted during the month of November-December 2017. This paper focuses on 13 identified buildings having roof of either flat or shed type which are shadow free and suitable to install roof top solar PV power plant. The total connected load, its type and roof area for each building is computed during the audit process. From the preliminary building energy audit data, the cost saving potential is calculated along with payback duration. As the buildings are in hilly region, we have also most hydro power plants (micro , mini and small) located similar to these regions thereby it can be implemented into all of hydro power stations across India. Solar power can be utilized through building integration or through floating solar PV plants in the reservoir (dam water storage areas) of hydro power stations.
DOI: 10.6084/m9.figshare.11841468.v1
title: ADDING-SOLAR-POWER-FOR-NET-ENERGY-ZERO-BUILDING.pdf

description: This paper deals with Building Energy Audit conducted at buildings located in a hilly region of West Bengal state and also provides the prospect of using solar energy to make all buildings achieve the status of Net Energy Zero Building. The study was conducted during the month of November-December 2017. This paper focuses on 13 identified buildings having roof of either flat or shed type which are shadow free and suitable to install roof top solar PV power plant. The total connected load, its type and roof area for each building is computed during the audit process. From the preliminary building energy audit data, the cost saving potential is calculated along with payback duration. As the buildings are in hilly region, we have also most hydro power plants (micro , mini and small) located similar to these regions thereby it can be implemented into all of hydro power stations across India. Solar power can be utilized through building integration or through floating solar PV plants in the reservoir (dam water storage areas) of hydro power stations.
DOI: 10.6084/m9.figshare.11841474
title: Supplementary Material for: Serum Alkaline Phosphatase Level Predicts Cardiac Valve Calcification in Maintenance Hemodialysis Patients

description: <b><i>Purpose:</i></b> Cardiac valve calcification (CVC) is frequently occurred in maintenance hemodialysis (MHD) patients and is associated with cardiovascular and all-cause mortality. This study aimed to evaluate the relationships between risk factors and extent of CVC and further provide the treatment target in MHD patients. <b><i>Methods:</i></b> One hundred and forty-five patients who received MHD ≥3 months were enrolled. CVC was assessed by an echocardiographic, semi-quantitative manner called global cardiac calcium scoring system (GCCS), and demographic, clinical, and laboratory parameters including mineral metabolism markers were collected. <b><i>Results:</i></b> The average age of the patients was 50 ± 12 years, and 54.5% were men. The mean GCCS was 1.8 ± 2.4; 57.2% of patients had GCCS ≥1. Age, dialysis vintage, serum alkaline phosphatase (ALP), and intact parathyroid hormone levels were positively correlated with CVC, whereas serum albumin levels were negatively related to CVC, based on univariate analysis. With multivariate linear regression analysis, serum ALP was the only bone-derived biomarker that showed significant correlation with CVC. Serum ALP ≥232 U/L was a robust predictor of CVC and was associated with the likelihood of GCCS ≥1 (OR 3.92, 95% CI 1.37–11.2, <i>p</i> = 0.011). The decision tree model was used to identify ALP ≥232 U/L and age ≥60 years as important determinative variables in the prediction of CVC in MHD patients. <b><i>Conclusion:</i></b> Serum ALP level is significantly associated with CVC in MHD patients. ALP is suggested to be a promising interventional target for cardiovascular calcification in MHD patients.
DOI: 10.6084/m9.figshare.11841462.v2
title: Metadata record for: Longitudinal spatial dataset on travel times and distances by different travel modes in Helsinki Region

description: This dataset contains key characteristics about the data described in the Data Descriptor Longitudinal spatial dataset on travel times and distances by different travel modes in Helsinki Region. <br> Contents: <br> 1. human readable metadata summary table in CSV format 2. machine readable metadata file in JSON format <br> <br> Versioning Note:Version 2 was generated when the metadata format was updated from JSON to JSON-LD. This was an automatic process that changed only the format, not the contents, of the metadata.<br>
DOI: 10.6084/m9.figshare.11841462.v1
title: Metadata record for: Longitudinal spatial dataset on travel times and distances by different travel modes in Helsinki Region

description: This dataset contains key characteristics about the data described in the Data Descriptor Longitudinal spatial dataset on travel times and distances by different travel modes in Helsinki Region. <br> Contents: <br> 1. human readable metadata summary table in CSV format 2. machine readable metadata file in JSON format
DOI: 10.6084/m9.figshare.11841441
title: Supplementary Material for: Morphofunctional Effects of C5 Convertase Blockade in Immune Complex-Mediated Membranoproliferative Glomerulonephritis: Report of Two Cases with Evidence of Terminal Complement Activation

description: A membranoproliferative pattern of glomerular injury is frequently observed in patients with complement-mediated disorders, such as C3 glomerulopathies (C3G) and primary immune complex-mediated membranoproliferative glomerulonephritis (IC-MPGN). The outcomes of C3G and ­IC-MPGN are poor, independently of immunosuppressive therapy. However, two 48-week treatment periods with the anti-C5 monoclonal antibody eculizumab, divided by a ­12-week washout period, achieved remission of proteinuria and stabilization/improvement of the glomerular filtration rate (GFR), measured through iohexol plasma clearance, in 3 of 10 patients with biopsy-proven MPGN, nephrotic syndrome and terminal complement complex sC5b-9 plasma levels &gt;1,000 mg/mL, at inclusion. Baseline and end-of-study kidney biopsies were available for 2 patients with IC-MPGN, and their baseline characteristics were similar. However, in 1 patient proteinuria and GFR did not improve during the study, whereas in the other proteinuria decreased from 4.84 to 2.12 g/24-h and GFR increased from 91.5 to 142.7 mL/min/1.73 m<sup>2</sup>. Glomerular inflammation improved and median (interquartile range) glomerular staining for C5b-9 decreased in both cases: from 23.6 to 18.2% (<i>p</i> = 0.021) in the patient who achieved remission and from 15.8 to 10.7% (<i>p</i> = 0.019) in the patient with persistent proteinuria. Chronic glomerular lesions progressed and C3 glomerular staining and electron-dense deposits did not change appreciably in either case. However, in the patient who achieved remission, ultrastructural evaluation revealed features of glomerular microangiopathy at inclusion, which fully recovered posttreatment. Podocyte foot process effacement was observed in both patients at inclusion, but recovered only in the patient with microangiopathy. Thus, in 2 patients with ­IC-MPGN, chronic glomerular changes progressed despite eculizumab-induced amelioration of glomerular inflammation and inhibition of sC5b-9 deposition, and independently of treatment effects on proteinuria and podocytes. The finding that the regression of microangiopathic changes was associated with improved clinical outcomes suggests that C5 blockade might have a therapeutic role in patients with IC-MPGN displaying microangiopathic endothelial injury.
DOI: 10.6084/m9.figshare.11841360
title: Supplementary Material for: Reversible Focal Dystonia Secondary to Giant Perivascular Spaces

description: Giant perivascular spaces (PVS) are rare, CSF-filled, dilated cavities lined by the pia mater that are most often asymptomatic radiological findings but can sometimes cause neurological symptoms. We present two exceptional cases of secondary focal dystonia induced by the mass effect on the basal ganglia caused by giant diencephalic PVSs. In both cases, we chose a surgical stereotactic drainage approach as a treatment strategy that allowed controlling the movement disorders. The beneficial therapeutic effect was sustained at long-term follow-up. We believe that similar cases could be addressed successfully with this method.
DOI: 10.24376/rd.sgul.11841333
title: Newcotiana Farmer interview data

description: Codes with references and full code book for data of N=24 interviews with tobacco farmers, agronomists, policymakers and researchers in Spain and Italy. Codes are de-contexualized to preserve confidentiality.
DOI: 10.6084/m9.figshare.11841330
title: Supplementary Material for: Kellner’s Symptom Questionnaire, a Highly Sensitive Patient-Reported Outcome Measure: Systematic Review of Clinimetric Properties

description: <b><i>Introduction:</i></b> Patient-reported outcomes (PROs) are of increasing importance in clinical medicine. However, their evaluation by classic psychometric methods carries considerable limitations. The clinimetric approach provides a viable framework for their assessment. <b><i>Objective:</i></b> The aim of this paper was to provide a systematic review of clinimetric properties of the Symptom Questionnaire (SQ), a simple, self-rated instrument for the assessment of psychological symptoms (depression, anxiety, hostility, and somatization) and well-being (contentment, relaxation, friendliness, and physical well-being). <b><i>Methods:</i></b> The PRISMA guidelines were used. Electronic databases were searched from inception up to March 2019. Only original research articles, published in English, reporting data about the clinimetric properties of the SQ, were included. <b><i>Results:</i></b> A total of 284 studies was selected. The SQ has been used in populations of adults, adolescents, and older individuals. The scale significantly discriminated between subgroups of subjects in both clinical and nonclinical settings, and differentiated medical and psychiatric patients from healthy controls. In longitudinal studies and in controlled pharmacological and psychotherapy trials, it was highly sensitive to symptoms and well-being changes and discriminated between the effects of psychotropic drugs and placebo. <b><i>Conclusions:</i></b> The SQ is a highly sensitive clinimetric index. It may yield clinical information that similar scales would fail to provide and has a unique position among the PROs that are available. Its use in clinical trials is strongly recommended.
DOI: 10.24376/rd.sgul.11841333.v1
title: Newcotiana Farmer interview data

description: Codes with references and full code book for data of N=24 interviews with tobacco farmers, agronomists, policymakers and researchers in Spain and Italy. Codes are de-contexualized to preserve confidentiality.
DOI: 10.6084/m9.figshare.11841330.v1
title: Supplementary Material for: Kellner’s Symptom Questionnaire, a Highly Sensitive Patient-Reported Outcome Measure: Systematic Review of Clinimetric Properties

description: <b><i>Introduction:</i></b> Patient-reported outcomes (PROs) are of increasing importance in clinical medicine. However, their evaluation by classic psychometric methods carries considerable limitations. The clinimetric approach provides a viable framework for their assessment. <b><i>Objective:</i></b> The aim of this paper was to provide a systematic review of clinimetric properties of the Symptom Questionnaire (SQ), a simple, self-rated instrument for the assessment of psychological symptoms (depression, anxiety, hostility, and somatization) and well-being (contentment, relaxation, friendliness, and physical well-being). <b><i>Methods:</i></b> The PRISMA guidelines were used. Electronic databases were searched from inception up to March 2019. Only original research articles, published in English, reporting data about the clinimetric properties of the SQ, were included. <b><i>Results:</i></b> A total of 284 studies was selected. The SQ has been used in populations of adults, adolescents, and older individuals. The scale significantly discriminated between subgroups of subjects in both clinical and nonclinical settings, and differentiated medical and psychiatric patients from healthy controls. In longitudinal studies and in controlled pharmacological and psychotherapy trials, it was highly sensitive to symptoms and well-being changes and discriminated between the effects of psychotropic drugs and placebo. <b><i>Conclusions:</i></b> The SQ is a highly sensitive clinimetric index. It may yield clinical information that similar scales would fail to provide and has a unique position among the PROs that are available. Its use in clinical trials is strongly recommended.
DOI: 10.6084/m9.figshare.11841309
title: Supplementary Material for: Effect of Breathing Oxygen-Enriched Air on Exercise Performance in Patients with Chronic Obstructive Pulmonary Disease: Randomized, Placebo-Controlled, Cross-Over Trial

description: <b><i>Background:</i></b> Patients with chronic obstructive pulmonary disease (COPD) experience dyspnea and hypoxemia during exercise. <b><i>Objective:</i></b> The aim of this study was to evaluate the effects of breathing oxygen-enriched air on exercise performance and associated physiological changes in patients with COPD. <b><i>Methods:</i></b> In a randomized, placebo-controlled, single-blind, cross-over trial, 20 patients with COPD (11 women, age 65 ± 6 years, FEV<sub>1</sub> 64 ± 19% pred., resting SpO<sub>2</sub> ≥90%) performed 4 cycle ergospirometries to exhaustion using an incremental exercise test (IET) and a constant work rate (at 75% maximal workload with air) exercise test (CWRET), each with ambient (FiO<sub>2</sub> 0.21) and oxygen-enriched (FiO<sub>2</sub> 0.5) air. The main outcomes were the change in maximal workload in the IET and the change in exercise duration in the CWRET with oxygen versus air. Electrocardiogram, pulmonary gas exchange, thoracic volumes by inductance plethysmography, arterial blood gases, and cerebral and quadriceps muscle tissue oxygenation (CTO and MTO) were additionally measured. <b><i>Results:</i></b> In the IET, maximal workload increased from 96 ± 21 to 104 ± 28 W with oxygen. In the CWRET, exercise duration increased from 605 ± 274 to 963 ± 444 s with oxygen. At end-exercise with oxygen, CTO, MTO, PaO<sub>2</sub>, and PaCO<sub>2</sub> were increased, while V’E/V’CO<sub>2</sub> was reduced and thoracic volumes were similar. At the corresponding time to end of exercise with ambient air, oxygen decreased heart rate, respiratory rate, minute ventilation, and V’E/V’CO<sub>2</sub>, while oxygenation was increased. <b><i>Conclusion:</i></b> In COPD patients without resting hypoxemia, breathing oxygen-enriched air improves exercise performance. This relates to a higher arterial oxygen saturation promoting oxygen availability to muscle and cerebral tissue and an enhanced ventilatory efficiency. COPD patients may benefit from oxygen therapy during exercise training.
DOI: 10.6084/m9.figshare.11841261
title: Transcriptome data of tea variety zhenong 139 under 50 mg / L fluoride stress (first leaf, fifth leaf and root)

description: Transcriptome data of tea variety zhenong 139 under 50 mg / L fluoride stress (first leaf, fifth leaf and root)
DOI: 10.6084/m9.figshare.11841261.v1
title: Transcriptome data of tea variety zhenong 139 under 50 mg / L fluoride stress (first leaf, fifth leaf and root)

description: Transcriptome data of tea variety zhenong 139 under 50 mg / L fluoride stress (first leaf, fifth leaf and root)
DOI: 10.6084/m9.figshare.11841240
title: Climate_2020 Travel Award_cv.zip

description: Cover letter, cv and the recommendation letter of Climate_2020 Travel Award.
DOI: 10.6084/m9.figshare.11841240.v1
title: Climate_2020 Travel Award_cv.zip

description: Cover letter, cv and the recommendation letter of Climate_2020 Travel Award.
DOI: 10.6084/m9.figshare.11841231
title: Beaver (2014) wildfire growth curve reconstruction using nonconstant growth model

description: See project description for general summary of data structure. The attached file is table reporting the estimates of the posterior daily wildfire size time series for the Beaver Fire in California 2014.
DOI: 10.6084/m9.figshare.11841231.v1
title: Beaver (2014) wildfire growth curve reconstruction using nonconstant growth model

description: See project description for general summary of data structure. The attached file is table reporting the estimates of the posterior daily wildfire size time series for the Beaver Fire in California 2014.
DOI: 10.6084/m9.figshare.11841168
title: Figshare_Carreira_2020Feb.xlsx

description: Our data was collected using a specially build device to take 25 samples at the same time, at small scales (separated by a few cm). The samples were collected at several reefs during a cruise in the Great Barrier Reef in December 2014 (spatial study) and at a specific location (Bowling Green Bay; temporal study) during January 2015, both in Australia. Samples were collected for inorganic (NH<sub>4</sub><sup>+</sup>, NO<sub>3</sub><sup>-</sup>/NO<sub>2</sub><sup>-</sup> and HPO<sub>4</sub><sup>2-</sup>, total dissolved nitrogen – TDN) and organic nutrients (dissolved organic matter – DOC), chl <i>a</i> (as a proxy for phytoplankton, bacteria, and viruses. Finally, extra samples were taken using a Niskin bottle during the spatial study, measuring the same parameters as described above.
DOI: 10.6084/m9.figshare.11841168.v1
title: Figshare_Carreira_2020Feb.xlsx

description: Our data was collected using a specially build device to take 25 samples at the same time, at small scales (separated by a few cm). The samples were collected at several reefs during a cruise in the Great Barrier Reef in December 2014 (spatial study) and at a specific location (Bowling Green Bay; temporal study) during January 2015, both in Australia. Samples were collected for inorganic (NH<sub>4</sub><sup>+</sup>, NO<sub>3</sub><sup>-</sup>/NO<sub>2</sub><sup>-</sup> and HPO<sub>4</sub><sup>2-</sup>, total dissolved nitrogen – TDN) and organic nutrients (dissolved organic matter – DOC), chl <i>a</i> (as a proxy for phytoplankton, bacteria, and viruses. Finally, extra samples were taken using a Niskin bottle during the spatial study, measuring the same parameters as described above.
DOI: 10.6084/m9.figshare.11841156
title: Wind, STEREO-A, STEREO-B in situ data 2007-2018

description: These are python pickle files containing data for the publication Amerstorfer, U.V. et al. 2020 (to be published)
DOI: 10.6084/m9.figshare.11841156.v1
title: Wind, STEREO-A, STEREO-B in situ data 2007-2018

description: These are python pickle files containing data for the publication Amerstorfer, U.V. et al. 2020 (to be published)
DOI: 10.6084/m9.figshare.11841099
title: The anatomy of institutions: diagnosing the formation of legal rules

description: The explanation for the outcomes of environmental policies is often sought either in policy design or in the behaviour of street-level bureaucrats, thus tending to examine only one level of the policy process and neglecting its multi-level nested nature. Specifically, most of the studies omit addressing policy specification, which is located between design and adoption of primary legislation and the actions of public service workers. Considering the policy process as a multi-level nested process of shaping and carrying out legal rules, this paper uses an institutional economics approach and the institutional grammar tool for its analysis. Using the example of the Ukrainian soil protection policy, it examines the way legal rules are being co-created and the policy objectives shaped at the policy specification stage and discusses the implications for the discretion of street-level bureaucrats, behaviour of the policy target group, and soil protection. The results of the study reveal that the desired outcomes of the Ukrainian soil protection policy are undermined because many institutional statements written in primary legislation are not supported by the expectation of remedy in case of non-compliance and are therefore dysfunctional.
DOI: 10.6084/m9.figshare.11841105
title: King (2014) wildfire growth curve reconstruction using nonconstant growth model

description: See project description for general summary of data structure. The attached file is table reporting the estimates of the posterior daily wildfire size time series for the King Fire in California 2014.
DOI: 10.6084/m9.figshare.11841027
title: AIBECS-OCIM2

description: This is the control version of the Ocean Circulation Inverse Model (OCIM) version 2 (with Helium), or "OCIM2_CTL_He", converted to an AIBECS-ready format.<br><br>If you use this data, please cite the DeVries and Holzer reference (doi attached to this file).<br><br>