cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.7284644
title: Supplementary Material for: Increased Risk for Cardiovascular Events in Patients with Diabetic Kidney Disease and Non-Alcoholic Fatty Liver Disease

description: <b><i>Background/Aims:</i></b> Non-alcoholic fatty liver disease (NAFLD) is recognised to be a strong risk factor for causing cardiovascular disease (CVD) and chronic kidney disease (CKD), independent of the presence of diabetes mellitus. The association of NAFLD with outcomes in patients with diabetic kidney disease (DKD) has been variably reported. This study aimed to investigate the association of NAFLD with cardiovascular, renal outcomes and mortality in patients with advanced DKD (CKD 3–5, not on dialysis). <b><i>Methods:</i></b> This observational study was carried out on 192 patients with DKD within a cohort of 2,974 non-dialysis CKD patients, who had an ultrasound (US) of their liver done between January 2000 and end of December 2014. From these 192 patients, 149 patients (NAFLD 48 and normal US 101) were included for comparative analysis, as they had complete datasets. Patient demographics, comorbidities and blood results were collected at study baseline. Follow-up data on non-fatal cardiovascular events (NFCVE), mortality and serial estimated glomerular filtration rate (eGFR) was gathered until study end point. Cox-regression analysis was used to study the association of NAFLD with NFCVE and mortality, and linear regression analysis was used for the estimation of renal progression. <b><i>Results:</i></b> Median follow-up time was 69 months, similar in both groups (<i>p</i> = 0.09). Median eGFR was 31.6 mL/min/1.73 m<sup>2</sup>, with a median urine protein creatinine ratio of 46 g/mol. A total of 20 (41.7%) NFCVE were recorded in the NAFLD group compared to 14 (13.9%) in the normal US group. Multivariable Cox-regression analysis showed NAFLD as an independent risk factor (hazard ratio 2.95; 95% CI 1.31–6.60; <i>p</i> = 0.01) for NFCVE even after including all cardiovascular risks parameters that were significant in the univariable model. There was no significant difference in survival between the 2 groups over the follow-up period (log-rank test, <i>p</i> = 0.76). The overall rate of decline in eGFR was 3.46 mL/min/1.73 m<sup>2</sup>/year and this was not observed to be different between the groups (<i>p</i> = 0.65). <b><i>Conclusion:</i></b> In our cohort of patients with advanced DKD, NAFLD showed a strong independent association with cardiovascular outcomes. Further prospective studies are warranted to strengthen these associations and plan a strategy for screening NAFLD in this high-risk group.
DOI: 10.6084/m9.figshare.7284647.v1
title: Supplementary Material for: Geriatric Assessment in Elderly Patients with End-Stage Kidney Disease

description: <b><i>Background/Aims:</i></b> Decision-making in elderly patients considering dialysis is highly complex. With the increasing number of elderly with end-stage kidney disease (ESKD), it may be important to assess geriatric impairments in this population. The aim of the Geriatric assessment in OLder patients starting Dialysis (GOLD) study was to assess the prevalence of geriatric impairments and frailty in the elderly ESKD population by means of a geriatric assessment (GA), which is a comprehensive tool for overall health assessment. <b><i>Methods:</i></b> This study included 285 patients ≥65 years: 196 patients at the time of dialysis initiation and 89 patients who chose maximal conservative management (MCM). The GA assessed cognition, mood, nutritional status, (instrumental) activities of daily living (ADL), mobility, comorbidity burden, quality of life and overall frailty. <b><i>Results:</i></b> The mean age of the participants was 78 years and 36% were women. Of the incident dialysis patients, 77% started haemodialysis and 23% started peritoneal dialysis. Geriatric impairments were highly prevalent in both dialysis and MCM patients. Most frequently impaired geriatric domains in the dialysis group were functional performance (ADL 29%, instrumental ADL (iADL) 79%), cognition (67%) and comorbidity (41%). According to the GA, 77% in the dialysis group and 88% in the MCM group had 2 or more geriatric impairments. In the MCM group, functional impairment (ADL 45%, iADL 85%) was highly prevalent. <b><i>Conclusions:</i></b> Geriatric impairments are highly prevalent in the elderly ESKD population. Since impairments can be missed when not searched for in regular (pre)dialysis care, the first step of improving nephrologic care is awareness of the extensiveness of geriatric impairment.
DOI: 10.7284/120428
title: Gyrocompass data collected during research cruise SAV-14-05 using a Yokogawa CMZ700B instrument system onboard the platform RV Savannah

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7284644.v1
title: Supplementary Material for: Increased Risk for Cardiovascular Events in Patients with Diabetic Kidney Disease and Non-Alcoholic Fatty Liver Disease

description: <b><i>Background/Aims:</i></b> Non-alcoholic fatty liver disease (NAFLD) is recognised to be a strong risk factor for causing cardiovascular disease (CVD) and chronic kidney disease (CKD), independent of the presence of diabetes mellitus. The association of NAFLD with outcomes in patients with diabetic kidney disease (DKD) has been variably reported. This study aimed to investigate the association of NAFLD with cardiovascular, renal outcomes and mortality in patients with advanced DKD (CKD 3–5, not on dialysis). <b><i>Methods:</i></b> This observational study was carried out on 192 patients with DKD within a cohort of 2,974 non-dialysis CKD patients, who had an ultrasound (US) of their liver done between January 2000 and end of December 2014. From these 192 patients, 149 patients (NAFLD 48 and normal US 101) were included for comparative analysis, as they had complete datasets. Patient demographics, comorbidities and blood results were collected at study baseline. Follow-up data on non-fatal cardiovascular events (NFCVE), mortality and serial estimated glomerular filtration rate (eGFR) was gathered until study end point. Cox-regression analysis was used to study the association of NAFLD with NFCVE and mortality, and linear regression analysis was used for the estimation of renal progression. <b><i>Results:</i></b> Median follow-up time was 69 months, similar in both groups (<i>p</i> = 0.09). Median eGFR was 31.6 mL/min/1.73 m<sup>2</sup>, with a median urine protein creatinine ratio of 46 g/mol. A total of 20 (41.7%) NFCVE were recorded in the NAFLD group compared to 14 (13.9%) in the normal US group. Multivariable Cox-regression analysis showed NAFLD as an independent risk factor (hazard ratio 2.95; 95% CI 1.31–6.60; <i>p</i> = 0.01) for NFCVE even after including all cardiovascular risks parameters that were significant in the univariable model. There was no significant difference in survival between the 2 groups over the follow-up period (log-rank test, <i>p</i> = 0.76). The overall rate of decline in eGFR was 3.46 mL/min/1.73 m<sup>2</sup>/year and this was not observed to be different between the groups (<i>p</i> = 0.65). <b><i>Conclusion:</i></b> In our cohort of patients with advanced DKD, NAFLD showed a strong independent association with cardiovascular outcomes. Further prospective studies are warranted to strengthen these associations and plan a strategy for screening NAFLD in this high-risk group.
DOI: 10.7284/120426
title: Meteorological Station data collected during research cruise SAV-14-05 using a RM Young 26800 instrument system onboard the platform RV Savannah

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7284614
title: A potential role of extended simple sequence repeats in competing endogenous RNA crosstalk

description: MicroRNA (miRNA)-mediated crosstalk between coding and non-coding RNAs of various types is known as the competing endogenous RNA (ceRNA) concept. Here, we propose that there is a specific variant of the ceRNA language that takes advantage of simple sequence repeat (SSR) wording. We applied bioinformatics tools to identify human transcripts that may be regarded as repeat-associated ceRNAs (raceRNAs). Multiple protein-coding transcripts, transcribed pseudogenes, long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) showing this potential were identified, and numerous miRNAs were predicted to bind to SSRs. We propose that simple repeats expanded in various hereditary neurological diseases may act as sponges for miRNAs containing complementary repeats that would affect raceRNA crosstalk. Based on the representation of specific SSRs in transcripts, expression data for SSR-binding miRNAs and expression profiling data from patients, we determined that raceRNA crosstalk is most likely to be perturbed in the case of myotonic dystrophy type 1 (DM1) and type 2 (DM2).
DOI: 10.7284/120425
title: Singlebeam Echosounder data collected during research cruise SAV-14-05 using a Furuno FCV-582 instrument system onboard the platform RV Savannah

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/120429
title: TSG (Thermosalinograph) data collected during research cruise SAV-14-05 using a Sea-Bird SBE-21 instrument system onboard the platform RV Savannah

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7284614.v1
title: A Potential Role of Extended Simple Sequence Repeats in Competing Endogenous RNA Crosstalk

description: MicroRNA (miRNA)-mediated crosstalk between coding and non-coding RNAs of various types is known as the competing endogenous RNA (ceRNA) concept. Here, we propose that there is a specific variant of the ceRNA language that takes advantage of simple sequence repeat (SSR) wording. We applied bioinformatics tools to identify human transcripts that may be regarded as repeat-associated ceRNAs (raceRNAs). Multiple protein-coding transcripts, transcribed pseudogenes, long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) showing this potential were identified, and numerous miRNAs were predicted to bind to SSRs. We propose that simple repeats expanded in various hereditary neurological diseases may act as sponges for miRNAs containing complementary repeats that would affect raceRNA crosstalk. Based on the representation of specific SSRs in transcripts, expression data for SSR-binding miRNAs and expression profiling data from patients, we determined that raceRNA crosstalk is most likely to be perturbed in the case of myotonic dystrophy type 1 (DM1) and type 2 (DM2).
DOI: 10.7284/116965
title: GNSS (Global Navigation Satellite System) data collected during research cruise SAV-14-06 using a Furuno GP-90 instrument system onboard the platform RV Savannah

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7284614.v3
title: A potential role of extended simple sequence repeats in competing endogenous RNA crosstalk

description: MicroRNA (miRNA)-mediated crosstalk between coding and non-coding RNAs of various types is known as the competing endogenous RNA (ceRNA) concept. Here, we propose that there is a specific variant of the ceRNA language that takes advantage of simple sequence repeat (SSR) wording. We applied bioinformatics tools to identify human transcripts that may be regarded as repeat-associated ceRNAs (raceRNAs). Multiple protein-coding transcripts, transcribed pseudogenes, long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) showing this potential were identified, and numerous miRNAs were predicted to bind to SSRs. We propose that simple repeats expanded in various hereditary neurological diseases may act as sponges for miRNAs containing complementary repeats that would affect raceRNA crosstalk. Based on the representation of specific SSRs in transcripts, expression data for SSR-binding miRNAs and expression profiling data from patients, we determined that raceRNA crosstalk is most likely to be perturbed in the case of myotonic dystrophy type 1 (DM1) and type 2 (DM2).
DOI: 10.6084/m9.figshare.7284614.v2
title: A potential role of extended simple sequence repeats in competing endogenous RNA crosstalk

description: MicroRNA (miRNA)-mediated crosstalk between coding and non-coding RNAs of various types is known as the competing endogenous RNA (ceRNA) concept. Here, we propose that there is a specific variant of the ceRNA language that takes advantage of simple sequence repeat (SSR) wording. We applied bioinformatics tools to identify human transcripts that may be regarded as repeat-associated ceRNAs (raceRNAs). Multiple protein-coding transcripts, transcribed pseudogenes, long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) showing this potential were identified, and numerous miRNAs were predicted to bind to SSRs. We propose that simple repeats expanded in various hereditary neurological diseases may act as sponges for miRNAs containing complementary repeats that would affect raceRNA crosstalk. Based on the representation of specific SSRs in transcripts, expression data for SSR-binding miRNAs and expression profiling data from patients, we determined that raceRNA crosstalk is most likely to be perturbed in the case of myotonic dystrophy type 1 (DM1) and type 2 (DM2).
DOI: 10.7284/120433
title: Gyrocompass data collected during research cruise SAV-14-06 using a Yokogawa CMZ700B instrument system onboard the platform RV Savannah

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7284584
title: QuickPALM: STORM over the Eiffel Tower

description: Single-molecule localization microscopy analysis being applied to a movie of the Eiffel Tower at night where a random activation of lights is being used. Movies where created in Institut Pasteur during my PhD while being hosted by the Christophe Zimmer laboratory, circa 2010.
DOI: 10.7284/120431
title: Meteorological Station data collected during research cruise SAV-14-06 using a RM Young 26800 instrument system onboard the platform RV Savannah

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/120430
title: Singlebeam Echosounder data collected during research cruise SAV-14-06 using a Furuno FCV-582 instrument system onboard the platform RV Savannah

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/120434
title: TSG (Thermosalinograph) data collected during research cruise SAV-14-06 using a Sea-Bird SBE-21 instrument system onboard the platform RV Savannah

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/120437
title: CTD (Conductivity, Temperature, Depth) data collected during research cruise SAV-14-07 using a Sea-Bird SBE-25 instrument system onboard the platform RV Savannah

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/116966
title: GNSS (Global Navigation Satellite System) data collected during research cruise SAV-14-07 using a Furuno GP-90 instrument system onboard the platform RV Savannah

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/120438
title: Gyrocompass data collected during research cruise SAV-14-07 using a Yokogawa CMZ700B instrument system onboard the platform RV Savannah

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/120436
title: Meteorological Station data collected during research cruise SAV-14-07 using a RM Young 26800 instrument system onboard the platform RV Savannah

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/120435
title: Singlebeam Echosounder data collected during research cruise SAV-14-07 using a Furuno FCV-582 instrument system onboard the platform RV Savannah

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/120439
title: TSG (Thermosalinograph) data collected during research cruise SAV-14-07 using a Sea-Bird SBE-21 instrument system onboard the platform RV Savannah

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/116967
title: GNSS (Global Navigation Satellite System) data collected during research cruise SAV-14-08 using a Furuno GP-90 instrument system onboard the platform RV Savannah

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/116968
title: GNSS (Global Navigation Satellite System) data collected during research cruise SAV-14-09 using a Furuno GP-90 instrument system onboard the platform RV Savannah

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/120454
title: CTD (Conductivity, Temperature, Depth) data collected during research cruise SAV-14-10 using a Sea-Bird SBE-25 instrument system onboard the platform RV Savannah

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/116969
title: GNSS (Global Navigation Satellite System) data collected during research cruise SAV-14-10 using a Furuno GP-90 instrument system onboard the platform RV Savannah

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/120455
title: Gyrocompass data collected during research cruise SAV-14-10 using a Yokogawa CMZ700B instrument system onboard the platform RV Savannah

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/120453
title: Meteorological Station data collected during research cruise SAV-14-10 using a RM Young 26800 instrument system onboard the platform RV Savannah

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7284416
title: Characterization of Methylation and Hydroxymethylation of 146 Microsatellites based on MeDIP-seq and hMeDIP-seq in Precocious Eriocheir sinensis Testes_sup

description: <b>Characterization of Methylation and Hydroxymethylation of 146 Microsatellites based on MeDIP-seq and hMeDIP-seq in Precocious Eriocheir sinensis Testes_sup</b><br>
DOI: 10.7284/120452
title: Singlebeam Echosounder data collected during research cruise SAV-14-10 using a Furuno FCV-582 instrument system onboard the platform RV Savannah

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7284416.v1
title: Characterization of Methylation and Hydroxymethylation of 146 Microsatellites based on MeDIP-seq and hMeDIP-seq in Precocious Eriocheir sinensis Testes_sup

description: <b>Characterization of Methylation and Hydroxymethylation of 146 Microsatellites based on MeDIP-seq and hMeDIP-seq in Precocious Eriocheir sinensis Testes_sup</b><br>
DOI: 10.7284/120456
title: TSG (Thermosalinograph) data collected during research cruise SAV-14-10 using a Sea-Bird SBE-21 instrument system onboard the platform RV Savannah

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/120457
title: ADCP (Acoustic Doppler Current Profiler) data collected during research cruise SAV-14-11 using a RDI WM-300 instrument system onboard the platform RV Savannah

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7284392
title: nautical cargo mail id.txt

description: nautical mail ids<br>
DOI: 10.6084/m9.figshare.7284392.v1
title: nautical cargo mail id.txt

description: nautical mail ids<br>
DOI: 10.7284/116970
title: GNSS (Global Navigation Satellite System) data collected during research cruise SAV-14-11 using a Furuno GP-90 instrument system onboard the platform RV Savannah

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/120461
title: Gyrocompass data collected during research cruise SAV-14-11 using a Yokogawa CMZ700B instrument system onboard the platform RV Savannah

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7284251.v1
title: Lake Catchment Set

description: A freely available data set of inland lake catchments including lakes, location, shape, area, perimeter, etc. over the Qiangtang Plateau which is a main part of the Tibetan Plateau. The data set is derived from Landset8 images, Google Earth and Digital Elevation Model (DEM). It will provide important basic information for researchers to study the changes of meteorology, hydrology and environment and its mechanism in Qinghai-Tibet Plateau.
DOI: 10.7284/120459
title: Meteorological Station data collected during research cruise SAV-14-11 using a RM Young 26800 instrument system onboard the platform RV Savannah

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/120458
title: Singlebeam Echosounder data collected during research cruise SAV-14-11 using a Furuno FCV-582 instrument system onboard the platform RV Savannah

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/120462
title: TSG (Thermosalinograph) data collected during research cruise SAV-14-11 using a Sea-Bird SBE-21 instrument system onboard the platform RV Savannah

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/116971
title: GNSS (Global Navigation Satellite System) data collected during research cruise SAV-14-12 using a Furuno GP-90 instrument system onboard the platform RV Savannah

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/120471
title: CTD (Conductivity, Temperature, Depth) data collected during research cruise SAV-14-13 using a Sea-Bird SBE-25 instrument system onboard the platform RV Savannah

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7283807
title: 11 plants genome

description: <b>The eleven species of genome-sequenced plant</b>
DOI: 10.7284/116972
title: GNSS (Global Navigation Satellite System) data collected during research cruise SAV-14-13 using a Furuno GP-90 instrument system onboard the platform RV Savannah

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7283807.v1
title: table4.xlsx

description: <b>The eleven species of genome-sequenced plant</b>
DOI: 10.7284/120472
title: Gyrocompass data collected during research cruise SAV-14-13 using a Yokogawa CMZ700B instrument system onboard the platform RV Savannah

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7283690
title: <i>In Silico</i> development of new SSRs primer for aquaporin linked to drought tolerance in plants

description: Plants are exposed to various stress factors including biotic and abiotic stresses. Drought is a limiting factor that minimizes the development and growth of several plants in arid and semi-arid regions. Stress response is usually occur at different levels, Morphological, physiological and biochemical while at the molecular level a large number of genes are involved. This study aims at developing a new SSR primer for aquaporin related to drought stress in plants. A total of 177 complete coding sequences (CDS) available in the NCBI database are downloaded. After analyzing with BLAST, 163 sequences are selected. 1294 SSR derived from these sequences are characterized with MISA and indicating that all sequences contained SSRs. The most abundant SSR has been tetra-nucleotide repeat motif (36%) and among all the tetra-nucleotide repeats, the motif AAAG/CTTT was the most common type, whereas in tri-nucleotide, the motif CCG/CGG has been the predominate type. By using Primer3, 1120 primer pairs are generated and after analyzing, only 735 non redundant primer pairs that present the good characteristics are selected. Among them, some of the pairs of primers are randomly selected and validated on DNA of various species using PCR and agarose gel.