cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.5718613.v1
title: Expression of E-cadherin, Slug and NCAM and its relationship to tumor invasiveness in patients with acromegaly

description: Pituitary adenomas account for 10–15% of primary intracranial tumors. Growth hormone (GH)-secreting adenomas account for 13% of all pituitary adenomas and cause acromegaly. These tumors can be aggressive, invade surrounding structures and are highly recurrent. The objective of this study was to evaluate E-cadherin, Slug and neural cell adhesion molecule (NCAM) expression in GH-secreting pituitary adenomas and its relationship to tumor invasiveness. A cross–sectional study of patients who underwent hypophysectomy due to GH-secreting pituitary adenoma from April 2007 to December 2014 was carried out. The medical records were reviewed to collect clinical data. Immediately after surgery, tumor samples were frozen in liquid nitrogen and stored in a biofreezer at –80°C for assessment of E-cadherin 1 (CDH1), SLUG (SNAI2), and NCAM (NCAM1) by real-time PCR. The samples were fixed in formalin and embedded in paraffin for immunohistochemical analysis of E-cadherin and NCAM. Thirty-five patients with acromegaly were included in the study. Of these, 65.7% had invasive tumors. Immunohistochemically, E-cadherin was expressed in 96.7% of patients, and NCAM in 80% of patients. There was no statistically significant relationship between tumor grade or invasiveness and immunohistochemical expression of these markers. Regarding gene expression, 50% of cases expressed CDH1, none expressed SNAI2, and 53.3% expressed NCAM1. There was no statistically significant relationship between tumor grade or invasiveness and gene expression of CDH1, SNAI2, and NCAM1. The absence of Slug overexpression and of E-cadherin and NCAM suppression suggests that expression of these markers is not associated with tumor invasiveness in GH-secreting pituitary adenomas.
DOI: 10.6084/m9.figshare.5718607
title: Pestalozzi's Intuitive Pedagogy of Elementary School: how Arithmetic was taught?

description: Abstract This article aims to understand the methodological arrangement in Pestalozzi's arithmetic teaching in elementary school. The question arises: How arithmetic was taught in the Pestalozzi elementary school way? By transforming some of Pestalozzi texts in documents, I noticed that the Swiss teacher systematized a pedagogical theory that changed the status of the triad: student-knowledge-teacher. This is a pedagogy based in the activity of the human spirit manifested by intuition. I called it intuitive pedagogy. A pedagogy that psychologized the elementary knowledge, under the pretext of following human nature through the sensitive and rational intuitions. Put together in the simplest form, the knowledge of arithmetic has been reduced, in some way, to the tangible, visible and accessible elements to all senses.
DOI: 10.6084/m9.figshare.5718607.v1
title: Pestalozzi's Intuitive Pedagogy of Elementary School: how Arithmetic was taught?

description: Abstract This article aims to understand the methodological arrangement in Pestalozzi's arithmetic teaching in elementary school. The question arises: How arithmetic was taught in the Pestalozzi elementary school way? By transforming some of Pestalozzi texts in documents, I noticed that the Swiss teacher systematized a pedagogical theory that changed the status of the triad: student-knowledge-teacher. This is a pedagogy based in the activity of the human spirit manifested by intuition. I called it intuitive pedagogy. A pedagogy that psychologized the elementary knowledge, under the pretext of following human nature through the sensitive and rational intuitions. Put together in the simplest form, the knowledge of arithmetic has been reduced, in some way, to the tangible, visible and accessible elements to all senses.
DOI: 10.6084/m9.figshare.5718604
title: MAXILLOFACIAL TRAUMA, ETIOLOGY AND PROFILE OF PATIENTS: AN EXPLORATORY STUDY

description: ABSTRACT Objective: To describe the profile of patients with facial trauma admitted in a hospital located in a metropolitan area of Northeast Brazil. Methods: A cross-sectional and exploratory study was performed. A total of 244 cases were in agreement with the eligibility criteria. The variables include the sociodemographic characteristics of patients, etiology, type of trauma, treatment modalities, length of stay in a hospital and quarter of care. Descriptive statistics and Cluster Analysis were performed. Results: The average age of patients was 31.16 years (SD = 15.17 years) and average hospitalization was 6.32 days (SD = 7.75 days). It was verified the automatic formation of four clusters with different profiles of patients. The variables which most contributed to the external differentiation between clusters were: length of stay in a hospital (p &lt;0.001), etiology (p &lt;0.001), type of facial trauma (p &lt;0.001), presence of associated trauma (p &lt;0.001), treatment modalities (p &lt;0.001) and quarter of care (p &lt;0.001). Conclusion: The most of patients were men, victims of traffic accidents, which suffered fracture of zygomatic complex and underwent surgery. Level of Evidence III, Retrospective Study.
DOI: 10.6084/m9.figshare.5718604.v1
title: MAXILLOFACIAL TRAUMA, ETIOLOGY AND PROFILE OF PATIENTS: AN EXPLORATORY STUDY

description: ABSTRACT Objective: To describe the profile of patients with facial trauma admitted in a hospital located in a metropolitan area of Northeast Brazil. Methods: A cross-sectional and exploratory study was performed. A total of 244 cases were in agreement with the eligibility criteria. The variables include the sociodemographic characteristics of patients, etiology, type of trauma, treatment modalities, length of stay in a hospital and quarter of care. Descriptive statistics and Cluster Analysis were performed. Results: The average age of patients was 31.16 years (SD = 15.17 years) and average hospitalization was 6.32 days (SD = 7.75 days). It was verified the automatic formation of four clusters with different profiles of patients. The variables which most contributed to the external differentiation between clusters were: length of stay in a hospital (p &lt;0.001), etiology (p &lt;0.001), type of facial trauma (p &lt;0.001), presence of associated trauma (p &lt;0.001), treatment modalities (p &lt;0.001) and quarter of care (p &lt;0.001). Conclusion: The most of patients were men, victims of traffic accidents, which suffered fracture of zygomatic complex and underwent surgery. Level of Evidence III, Retrospective Study.
DOI: 10.6084/m9.figshare.5718601
title: Open innovation in the research and development process: an analysis of the cooperation between automotive companies and universities

description: Abstract: The growing demand for innovation and the need for reducing time and cost of new products development have changed the Brazilian automobile scenario, which has been characterized by a closed innovation model for a long time. Flex fuel technology has been a challenge for the companies in this sector, and it is the motivating factor of this study, which aimed to understand the open innovation process within the fuzzy front end context, identifying the main motivations and implementation gaps. In order to reach this goal, a longitudinal case study has been carried out in a consortium composed by nine companies and two universities. The methodology has involved some qualitative and quantitative research. The main theoretical contribution from this research is precisely the pioneering concerning the automobile assembly companies working in a collaborative way. This research has also major managerial implications. It points out the peculiarities that shall be considered in a coopetition environment, as well as makes suggestions to the managers regarding the way of working the initial innovation phases. The research portrays well the role of the Universities in this context.
DOI: 10.6084/m9.figshare.5718601.v1
title: Open innovation in the research and development process: an analysis of the cooperation between automotive companies and universities

description: Abstract: The growing demand for innovation and the need for reducing time and cost of new products development have changed the Brazilian automobile scenario, which has been characterized by a closed innovation model for a long time. Flex fuel technology has been a challenge for the companies in this sector, and it is the motivating factor of this study, which aimed to understand the open innovation process within the fuzzy front end context, identifying the main motivations and implementation gaps. In order to reach this goal, a longitudinal case study has been carried out in a consortium composed by nine companies and two universities. The methodology has involved some qualitative and quantitative research. The main theoretical contribution from this research is precisely the pioneering concerning the automobile assembly companies working in a collaborative way. This research has also major managerial implications. It points out the peculiarities that shall be considered in a coopetition environment, as well as makes suggestions to the managers regarding the way of working the initial innovation phases. The research portrays well the role of the Universities in this context.
DOI: 10.6084/m9.figshare.5718598
title: Risk and protective factors for chronic diseases in adults: a population-based study

description: Abstract The article describes the relative frequency ok of risk and protective behaviors for chronic non-communicable diseases (NCDs) in adults residing in Viçosa, Brazil. A cross-section-al population-based study including 1,226 adults living in the municipality. We used a structured questionnaire containing questions sociodemographic and behavioral The risk and protection factors evaluated were: smoking, physical activity, excessive consumption of alcohol and food consumption. The proportion of risk and protection factors was calculated in the total population, according to gender, education and socioeconomic status. The studied population has a high frequency of risk factors for NCDs, such as excessive consumption of alcoholic beverages, habit of consuming whole milk, habit of eating meat with visible fat, regular consumption of soft drinks and 78.5% did not achieve the minimum recommendation for physical activity in leisure time. With regard to protective factors, 86.2% of the population reported regular consumption of fruits and vegetables, and 73%, of beans. It was found the highest frequency of risk factors in among males, in younger people and middle socioeconomic status. This population has an urgent need for public policy of municipal planning to change this current scenario.
DOI: 10.6084/m9.figshare.5718598.v1
title: Risk and protective factors for chronic diseases in adults: a population-based study

description: Abstract The article describes the relative frequency ok of risk and protective behaviors for chronic non-communicable diseases (NCDs) in adults residing in Viçosa, Brazil. A cross-section-al population-based study including 1,226 adults living in the municipality. We used a structured questionnaire containing questions sociodemographic and behavioral The risk and protection factors evaluated were: smoking, physical activity, excessive consumption of alcohol and food consumption. The proportion of risk and protection factors was calculated in the total population, according to gender, education and socioeconomic status. The studied population has a high frequency of risk factors for NCDs, such as excessive consumption of alcoholic beverages, habit of consuming whole milk, habit of eating meat with visible fat, regular consumption of soft drinks and 78.5% did not achieve the minimum recommendation for physical activity in leisure time. With regard to protective factors, 86.2% of the population reported regular consumption of fruits and vegetables, and 73%, of beans. It was found the highest frequency of risk factors in among males, in younger people and middle socioeconomic status. This population has an urgent need for public policy of municipal planning to change this current scenario.
DOI: 10.6084/m9.figshare.5718595
title: REPEATABILITY OF FRUIT QUALITY TRAITS OF CACTUS PEAR

description: ABSTRACT Repeatability analysis has been used to study traits in several crops, assisting in the definition of the minimum number needed to evaluate genotypes more efficiently and with less time and resource consumption. So far, however, no repeatability studies on cactus pear have been found in the literature. The objective of this study was to determine the coefficient of repeatability for cactus pear fruits traits and the minimum number of evaluations (fruit) that can provide acceptable accuracy for the prediction of the true value. The experiment was conducted at the Federal Institute of Bahia/Campus Guanambi, with 150 fruits collected from three municipalities in the state of Bahia. The coefficients of repeatability were estimated by the methods of analysis of variance, principal components based on the covariance (PCCV) and correlation (PCC) matrices, and structural analysis based on the correlation matrix (SA). The analysis of variance showed that, except for fruit diameter, the effect of the production site (municipality) was significant for all traits evaluated. The PCCV method was proven the most suitable for studying the repeatability of quality traits of cactus pear fruits. Seven fruits were required to determine, with 90% confidence, the traits length, diameter, fruit firmness, skin thickness, number of seeds, fruit mass, bark mass, pulp mass, pH, titratable acidity, soluble solids, SS/AT ratio, and pulp yield.
DOI: 10.6084/m9.figshare.5718595.v1
title: REPEATABILITY OF FRUIT QUALITY TRAITS OF CACTUS PEAR

description: ABSTRACT Repeatability analysis has been used to study traits in several crops, assisting in the definition of the minimum number needed to evaluate genotypes more efficiently and with less time and resource consumption. So far, however, no repeatability studies on cactus pear have been found in the literature. The objective of this study was to determine the coefficient of repeatability for cactus pear fruits traits and the minimum number of evaluations (fruit) that can provide acceptable accuracy for the prediction of the true value. The experiment was conducted at the Federal Institute of Bahia/Campus Guanambi, with 150 fruits collected from three municipalities in the state of Bahia. The coefficients of repeatability were estimated by the methods of analysis of variance, principal components based on the covariance (PCCV) and correlation (PCC) matrices, and structural analysis based on the correlation matrix (SA). The analysis of variance showed that, except for fruit diameter, the effect of the production site (municipality) was significant for all traits evaluated. The PCCV method was proven the most suitable for studying the repeatability of quality traits of cactus pear fruits. Seven fruits were required to determine, with 90% confidence, the traits length, diameter, fruit firmness, skin thickness, number of seeds, fruit mass, bark mass, pulp mass, pH, titratable acidity, soluble solids, SS/AT ratio, and pulp yield.
DOI: 10.6084/m9.figshare.5718592
title: Postgraduate teacher education: building a pedagogy of experience, towards a more democratic education

description: ABSTRACT Postgraduate teacher education can reframe teachers' thinking and actions towards a more democratic education in schools. On the basis of this assumption, a pedagogy of experience in teacher education settings is advocated and a strategy developed in a course of master degree for in-service teachers is described. In that context, teachers develop action-research experiences focused on the learners' autonomy and they produce narratives in which they describe and theorize those experiences, reflecting on their pedagogical and formative value. Through the analysis of six narratives, I will discuss the empowering potential of the approach in the construction of a critical view of education and democratic pedagogical practices.
DOI: 10.6084/m9.figshare.5718589
title: Algorithm for dry eye disease diagnosis in individuals infected with human T-cell lymphotropic virus type 1

description: ABSTRACT Purpose: To evaluate the accuracy of lacrimal film tests and propose an algorithm for the diagnosis of dry eye disease in individuals infected with human T-cell lymphotropic virus type 1. Methods: Ninety-six patients infected with human T-cell lymphotropic virus type 1 were enrolled in the study. To assess clinical complaints, patients completed the Ocular Surface Disease Index questionnaire. To evaluate lacrimal film quality, patients underwent the tear breakup time test, Schirmer I test, and Rose Bengal staining. Dry eye disease was diagnosed when at least two of the three test results were abnormal. The sensitivity, specificity, positive and negative predictive values, and overall accuracy of the questionnaire as well as of each test alone and combined in parallel and in series were determined. Results: The most sensitive test was the tear breakup time test (98%), whereas the most specific was the Schirmer I test (100%). Rose Bengal staining had the highest overall accuracy (88.64%), whereas the Ocular Surface Disease Index had the lowest overall accuracy (62.65%). The tear breakup time test, Schirmer I test, and Ocular Surface Disease Index combined in parallel showed increased sensitivity and decreased specificity for all tests. In contrast, when combined in series, these tests demonstrated increased specificity and decreased sensitivity. Conclusion: This study shows the need to use multiple tests to evaluate tear film quality and include a symptom questionnaire as part of the diagnostic algorithm for dry eye disease.
DOI: 10.6084/m9.figshare.5718589.v1
title: Algorithm for dry eye disease diagnosis in individuals infected with human T-cell lymphotropic virus type 1

description: ABSTRACT Purpose: To evaluate the accuracy of lacrimal film tests and propose an algorithm for the diagnosis of dry eye disease in individuals infected with human T-cell lymphotropic virus type 1. Methods: Ninety-six patients infected with human T-cell lymphotropic virus type 1 were enrolled in the study. To assess clinical complaints, patients completed the Ocular Surface Disease Index questionnaire. To evaluate lacrimal film quality, patients underwent the tear breakup time test, Schirmer I test, and Rose Bengal staining. Dry eye disease was diagnosed when at least two of the three test results were abnormal. The sensitivity, specificity, positive and negative predictive values, and overall accuracy of the questionnaire as well as of each test alone and combined in parallel and in series were determined. Results: The most sensitive test was the tear breakup time test (98%), whereas the most specific was the Schirmer I test (100%). Rose Bengal staining had the highest overall accuracy (88.64%), whereas the Ocular Surface Disease Index had the lowest overall accuracy (62.65%). The tear breakup time test, Schirmer I test, and Ocular Surface Disease Index combined in parallel showed increased sensitivity and decreased specificity for all tests. In contrast, when combined in series, these tests demonstrated increased specificity and decreased sensitivity. Conclusion: This study shows the need to use multiple tests to evaluate tear film quality and include a symptom questionnaire as part of the diagnostic algorithm for dry eye disease.
DOI: 10.6084/m9.figshare.5718577
title: The influence of non-steroidal anti-inflammatory drugs and paracetamol used for pain control of orthodontic tooth movement: a systematic review

description: ABSTRACT The present study aimed to perform a systematic literature review to determine if there is a non-steroidal anti-inflammatory drug (NSAID) that interferes less within tooth movement. This research was performed according to the PRISMA statement. Articles were searched in eight electronic databases (PubMed, Scopus, Embase, Web of Science, LILACS, SciELO, Google Scholar, and Open Grey). Only experimental studies on male Wistar rats were selected, which included experiments related to the influence of NSAIDs on orthodontic movement. Studies in animals with pathological conditions, literature review articles, letters to the editor and/or editorials, case reports, abstracts, books, and book chapters were excluded. Each of the steps of this systematic literature review was performed by two examiners independently. Results: the total sample consisted of 505 articles, from which 6 studies were eligible after a qualitative analysis. From the drugs assessed, paracetamol was unanimous for not interfering within orthodontic movement when compared to the control group. However, drugs such as aspirin, ibuprofen, sodium diclofenac, and selective cyclooxygenase-2 inhibitors caused a reduction in tooth movement when compared to the control group. Conclusion: paracetamol could be considered the drug of choice for pain relief because it interferes less within tooth movement.
DOI: 10.6084/m9.figshare.5718577.v1
title: The influence of non-steroidal anti-inflammatory drugs and paracetamol used for pain control of orthodontic tooth movement: a systematic review

description: ABSTRACT The present study aimed to perform a systematic literature review to determine if there is a non-steroidal anti-inflammatory drug (NSAID) that interferes less within tooth movement. This research was performed according to the PRISMA statement. Articles were searched in eight electronic databases (PubMed, Scopus, Embase, Web of Science, LILACS, SciELO, Google Scholar, and Open Grey). Only experimental studies on male Wistar rats were selected, which included experiments related to the influence of NSAIDs on orthodontic movement. Studies in animals with pathological conditions, literature review articles, letters to the editor and/or editorials, case reports, abstracts, books, and book chapters were excluded. Each of the steps of this systematic literature review was performed by two examiners independently. Results: the total sample consisted of 505 articles, from which 6 studies were eligible after a qualitative analysis. From the drugs assessed, paracetamol was unanimous for not interfering within orthodontic movement when compared to the control group. However, drugs such as aspirin, ibuprofen, sodium diclofenac, and selective cyclooxygenase-2 inhibitors caused a reduction in tooth movement when compared to the control group. Conclusion: paracetamol could be considered the drug of choice for pain relief because it interferes less within tooth movement.