cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.25549/hhrohp-ouc112340436
title: Kasia Malinowska (NJ) & Daniel Wolfe (NY), interview, USA, 2022

description: Kasia Malinowska, New Jersey, USA, and Daniel Wolfe, New York, New York, USA, 2022 June 16, oral history inteview, by Maylis Basturk, Los Angeles, California, USA. The inteview was conducted over the Internet (Zoom) as part of the Health and Human Rights Oral History Project.Kasia Malinowska-Sempruch and Daniel Wolfe both served previously in the role of Director of the International Harm Reduction Development Program at the Open Society Foundations (OSF), which supported the health and human rights of people who use drugs. Wolfe is a leading global expert on the intersection of HIV and drug policy and a member of the UN’s Strategic Advisory Group on HIV and drug use, and prior to OSF served as the Director of Communications at Gay Men’s Health Crisis among many other roles in the New York City AIDS movement. Malinowska-Sempruch, who previously worked for the United Nations Development Program, continues to work with OSF as Director of Global Drug Policy while publishing widely on issues of drug policy. In their oral history, they speak to their partnership shaping harm reduction policy and practice globally with OSF. Their conversation stretches from narcology clinics in Kyrgyzstan where Soviet systems of drug treatment gave way to evidence-based substitution therapy, to working with US-based reporters to increase public knowledge about the efficacy of needle exchange programs and drug decriminalization, to Vietnam during the COVID-19 pandemic, where grantees worked to deliver medicines to patients under lockdown.
DOI: 10.25549/hhrohp-ouc112340433
title: Kasia Malinowska (NJ) & Daniel Wolfe (NY), interview, USA, 2022

description: Kasia Malinowska, New Jersey, USA, and Daniel Wolfe, New York, New York, USA, 2022 June 16, oral history inteview, by Maylis Basturk, Los Angeles, California, USA. The inteview was conducted over the Internet (Zoom) as part of the Health and Human Rights Oral History Project.Kasia Malinowska-Sempruch and Daniel Wolfe both served previously in the role of Director of the International Harm Reduction Development Program at the Open Society Foundations (OSF), which supported the health and human rights of people who use drugs. Wolfe is a leading global expert on the intersection of HIV and drug policy and a member of the UN’s Strategic Advisory Group on HIV and drug use, and prior to OSF served as the Director of Communications at Gay Men’s Health Crisis among many other roles in the New York City AIDS movement. Malinowska-Sempruch, who previously worked for the United Nations Development Program, continues to work with OSF as Director of Global Drug Policy while publishing widely on issues of drug policy. In their oral history, they speak to their partnership shaping harm reduction policy and practice globally with OSF. Their conversation stretches from narcology clinics in Kyrgyzstan where Soviet systems of drug treatment gave way to evidence-based substitution therapy, to working with US-based reporters to increase public knowledge about the efficacy of needle exchange programs and drug decriminalization, to Vietnam during the COVID-19 pandemic, where grantees worked to deliver medicines to patients under lockdown.
DOI: 10.6084/m9.figshare.19608942
title: Identification of differential microRNAs and messenger RNAs resulting from ASXL transcriptional regulator 3 knockdown during during heart development

description: Congenital heart disease (CHD) is the most common birth defect. Although ASXL transcriptional regulator 3 (ASXL3) has been reported to cause hereditary CHD, ASXL3-mediated mechanisms in heart development remain unclear. In this study, we used dimethyl sulfoxide (DMSO) to induce differentiation in P19 cells, observed cell morphology using light microscopy after ASXL3 knockdown, and determined the levels of associated myocardial cell markers using reverse transcription-quantitative polymerase chain reaction and western blotting. Subsequently, we used microRNA sequencing, messenger RNA (mRNA) sequencing, and bioinformatics to initially identify the possible mechanisms through which ASXL3-related microRNAs and mRNAs affect heart development. The results indicated that DMSO induced P19 cell differentiation, which could be inhibited by ASXL3 knockdown. We screened 1214 and 1652 differentially expressed microRNAs and mRNAs, respectively, through ASXL3 knockdown and sequencing; these differentially expressed miRNAs were largely enriched in PI3K-Akt, mitogen-activated protein kinase, and Rap1 signaling pathways. Additionally, 11 miRNAs associated with heart development were selected through a literature review. Our analysis indicated the involvement of mmu-miR-323-3p in P19 cell differentiation through the PI3K-Akt pathway. In conclusion, ASXL3 may be involved in the regulation of heart development. This comprehensive study of differentially expressed microRNAs and mRNAs through ASXL3 knockdown in P19 cells provides new insights that may aid the prevention and treatment of CHD.
DOI: 10.25549/hhrohp-ouc112340432
title: Kasia Malinowska (NJ) & Daniel Wolfe (NY), interview, USA, 2022

description: Kasia Malinowska, New Jersey, USA, and Daniel Wolfe, New York, New York, USA, 2022 June 16, oral history inteview, by Maylis Basturk, Los Angeles, California, USA. The inteview was conducted over the Internet (Zoom) as part of the Health and Human Rights Oral History Project.Kasia Malinowska-Sempruch and Daniel Wolfe both served previously in the role of Director of the International Harm Reduction Development Program at the Open Society Foundations (OSF), which supported the health and human rights of people who use drugs. Wolfe is a leading global expert on the intersection of HIV and drug policy and a member of the UN’s Strategic Advisory Group on HIV and drug use, and prior to OSF served as the Director of Communications at Gay Men’s Health Crisis among many other roles in the New York City AIDS movement. Malinowska-Sempruch, who previously worked for the United Nations Development Program, continues to work with OSF as Director of Global Drug Policy while publishing widely on issues of drug policy. In their oral history, they speak to their partnership shaping harm reduction policy and practice globally with OSF. Their conversation stretches from narcology clinics in Kyrgyzstan where Soviet systems of drug treatment gave way to evidence-based substitution therapy, to working with US-based reporters to increase public knowledge about the efficacy of needle exchange programs and drug decriminalization, to Vietnam during the COVID-19 pandemic, where grantees worked to deliver medicines to patients under lockdown.
DOI: 10.6084/m9.figshare.23803228.v1
title: Additional file 2 of Changes in expression levels of erythrocyte and immune-related genes are associated with high altitude polycythemia

description: Supplementary Material 2
DOI: 10.6084/m9.figshare.23803231
title: Additional file 3 of Changes in expression levels of erythrocyte and immune-related genes are associated with high altitude polycythemia

description: Supplementary Material 3
DOI: 10.6084/m9.figshare.19608936
title: Plasmacytoma variant translocation 1 stabilized by EIF4A3 promoted malignant biological behaviors of lung adenocarcinoma by generating circular RNA LMNB2

description: Increasing evidence suggests that plasmacytoma variant translocation 1 (PVT1) plays a vital role in the development of multiple tumors including lung adenocarcinoma (LUAD). Eukaryotic initiation factor 4A-3 (EIF4A3) is considered a key factor in human cancers. However, the role and potential mechanism of PVT1 combined with EIF4A3 in LUAD remain unclear. This study investigated the effects and regulatory mechanisms of PVT1, EIF4A3, and circLMNB2 on the growth, migration, invasion, and epithelial-mesenchymal transition (EMT) of LUAD cells (H1299 and HCC827 cells) The expression level, diagnostic value and prognostic significance of PVT1, EIF4A3, and circLMNB2 were assessed, and enrichment analysis was performed using R package. Rescue experiments and a xenograft model were used to validate the PVT1/EIF4A3/circLMNB2 axis in LUAD. PVT1 and EIF4A3 were upregulated and indicated poor prognosis in LUAD. Knockdown of PVT1 and EIF4A3 suppressed LUAD cell proliferation, migration, invasion, and EMT. Mechanistically, PVT1 was stabilized by EIF4A3. PVT1 could recruit EIF4A3 to promote circLMNB2 expression. Rescue experiments indicated that circLMNB2 overexpression could reverse the reduced behavior caused by PVT1 or EIF4A3 knockdown. Enrichment analysis showed that PVT1/EIF4A3/circLMNB2 may regulate LUAD development by participating in ribosome biogenesis and spliceosome formation. Our findings demonstrate that PVT1/EIF4A3/circLMNB2 enhances the malignant behaviors of LUAD cells, providing a novel perspective for the clinical treatment of LUAD.
DOI: 10.25549/hhrohp-ouc112194240
title: Umunyana Rugege, interview, Johannesburg, South Africa, 2022

description: Umunyana Rugege, Johannesburg, South Africa, 2022 August 19, oral history interview, by Maylis Basturk, Los Angeles, California, USA. The inteview was conducted over the Internet (Zoom) as part of the Health and Human Rights Oral History Project.Umunyana Rugege is Executive Director of the South African public interest law center SECTION27, where she focuses on advancing constitutionally recognized economic and social rights, including the right to health. Her work has centered on health policy development and high impact litigation to help advance the right to healthcare, equality, and human dignity in South Africa. Rugege’s oral history charts the arc of SECTION27’s work on access to medicines, including the Fix the Patent Laws Campaign, which seeks to maximize the policy space available to respond to health emergencies and prevent monopoly patents from pricing essential medicines out of reach. She also describes the organization’s work to strengthen programs on comprehensive sexuality education and TB and to respond to the COVID-19 pandemic. Rugege reflects candidly on the structural and systemic issues within South Africa’s National Health Insurance scheme and calls for equitable governance structures that bring members of the community into decision-making roles across the healthcare system.
DOI: 10.6084/m9.figshare.19608942.v1
title: Identification of differential microRNAs and messenger RNAs resulting from ASXL transcriptional regulator 3 knockdown during during heart development

description: Congenital heart disease (CHD) is the most common birth defect. Although ASXL transcriptional regulator 3 (ASXL3) has been reported to cause hereditary CHD, ASXL3-mediated mechanisms in heart development remain unclear. In this study, we used dimethyl sulfoxide (DMSO) to induce differentiation in P19 cells, observed cell morphology using light microscopy after ASXL3 knockdown, and determined the levels of associated myocardial cell markers using reverse transcription-quantitative polymerase chain reaction and western blotting. Subsequently, we used microRNA sequencing, messenger RNA (mRNA) sequencing, and bioinformatics to initially identify the possible mechanisms through which ASXL3-related microRNAs and mRNAs affect heart development. The results indicated that DMSO induced P19 cell differentiation, which could be inhibited by ASXL3 knockdown. We screened 1214 and 1652 differentially expressed microRNAs and mRNAs, respectively, through ASXL3 knockdown and sequencing; these differentially expressed miRNAs were largely enriched in PI3K-Akt, mitogen-activated protein kinase, and Rap1 signaling pathways. Additionally, 11 miRNAs associated with heart development were selected through a literature review. Our analysis indicated the involvement of mmu-miR-323-3p in P19 cell differentiation through the PI3K-Akt pathway. In conclusion, ASXL3 may be involved in the regulation of heart development. This comprehensive study of differentially expressed microRNAs and mRNAs through ASXL3 knockdown in P19 cells provides new insights that may aid the prevention and treatment of CHD.
DOI: 10.25549/hhrohp-ouc112194241
title: Umunyana Rugege, interview, Johannesburg, South Africa, 2022

description: Umunyana Rugege, Johannesburg, South Africa, 2022 August 19, oral history interview, by Maylis Basturk, Los Angeles, California, USA. The inteview was conducted over the Internet (Zoom) as part of the Health and Human Rights Oral History Project.Umunyana Rugege is Executive Director of the South African public interest law center SECTION27, where she focuses on advancing constitutionally recognized economic and social rights, including the right to health. Her work has centered on health policy development and high impact litigation to help advance the right to healthcare, equality, and human dignity in South Africa. Rugege’s oral history charts the arc of SECTION27’s work on access to medicines, including the Fix the Patent Laws Campaign, which seeks to maximize the policy space available to respond to health emergencies and prevent monopoly patents from pricing essential medicines out of reach. She also describes the organization’s work to strengthen programs on comprehensive sexuality education and TB and to respond to the COVID-19 pandemic. Rugege reflects candidly on the structural and systemic issues within South Africa’s National Health Insurance scheme and calls for equitable governance structures that bring members of the community into decision-making roles across the healthcare system.
DOI: 10.25549/hhrohp-ouc112194142
title: Sofia Gruskin, interview, Los Angeles, CA, USA, 2022

description: Sofia Gruskin, Los Angeles, California, USA, 2022 September 15, oral history interview, by Maylis Basturk, Los Angeles, California, USA. The inteview was conducted over the Internet (Zoom) as part of the Health and Human Rights Oral History Project.Sofia Gruskin directs the USC Institute on Inequalities in Global Health (IIGH). She is Professor of Preventive Medicine and Chief of the Disease Prevention, Policy and Global Health Division at the Keck School of Medicine; Professor of Law and Preventive Medicine at the Gould School of Law; and an affiliate faculty member with the Spatial Sciences Institute at the USC Dornsife College of Letters, Arts and Sciences. A pioneer in bringing together multidisciplinary approaches to global health, Gruskin’s work — which ranges from global policy to the grassroots level — has been instrumental in developing the conceptual, methodological and empirical links between health and human rights. In her oral history, she returns to the origins of her work, from which has emerged a long-standing focus on HIV, sexual and reproductive health, child and adolescent health, gender-based violence, non-communicable disease, and health systems. She discusses the central role she played in first conceptualizing and popularizing the application of a human rights framework to health, and how she and her colleagues worked to integrate the concept across governments, civil society, UN agencies, and those in the public health space.
DOI: 10.25549/hhrohp-ouc112194239
title: Sofia Gruskin, interview, Los Angeles, CA, USA, 2022

description: Sofia Gruskin, Los Angeles, California, USA, 2022 September 15, oral history interview, by Maylis Basturk, Los Angeles, California, USA. The inteview was conducted over the Internet (Zoom) as part of the Health and Human Rights Oral History Project.Sofia Gruskin directs the USC Institute on Inequalities in Global Health (IIGH). She is Professor of Preventive Medicine and Chief of the Disease Prevention, Policy and Global Health Division at the Keck School of Medicine; Professor of Law and Preventive Medicine at the Gould School of Law; and an affiliate faculty member with the Spatial Sciences Institute at the USC Dornsife College of Letters, Arts and Sciences. A pioneer in bringing together multidisciplinary approaches to global health, Gruskin’s work — which ranges from global policy to the grassroots level — has been instrumental in developing the conceptual, methodological and empirical links between health and human rights. In her oral history, she returns to the origins of her work, from which has emerged a long-standing focus on HIV, sexual and reproductive health, child and adolescent health, gender-based violence, non-communicable disease, and health systems. She discusses the central role she played in first conceptualizing and popularizing the application of a human rights framework to health, and how she and her colleagues worked to integrate the concept across governments, civil society, UN agencies, and those in the public health space.
DOI: 10.25549/hhrohp-ouc112194238
title: Sofia Gruskin, interview, Los Angeles, CA, USA, 2022

description: Sofia Gruskin, Los Angeles, California, USA, 2022 September 15, oral history interview, by Maylis Basturk, Los Angeles, California, USA. The inteview was conducted over the Internet (Zoom) as part of the Health and Human Rights Oral History Project.Sofia Gruskin directs the USC Institute on Inequalities in Global Health (IIGH). She is Professor of Preventive Medicine and Chief of the Disease Prevention, Policy and Global Health Division at the Keck School of Medicine; Professor of Law and Preventive Medicine at the Gould School of Law; and an affiliate faculty member with the Spatial Sciences Institute at the USC Dornsife College of Letters, Arts and Sciences. A pioneer in bringing together multidisciplinary approaches to global health, Gruskin’s work — which ranges from global policy to the grassroots level — has been instrumental in developing the conceptual, methodological and empirical links between health and human rights. In her oral history, she returns to the origins of her work, from which has emerged a long-standing focus on HIV, sexual and reproductive health, child and adolescent health, gender-based violence, non-communicable disease, and health systems. She discusses the central role she played in first conceptualizing and popularizing the application of a human rights framework to health, and how she and her colleagues worked to integrate the concept across governments, civil society, UN agencies, and those in the public health space.
DOI: 10.25549/hhrohp-ouc112194237
title: Sofia Gruskin, interview, Los Angeles, CA, USA, 2022

description: Sofia Gruskin, Los Angeles, California, USA, 2022 September 15, oral history interview, by Maylis Basturk, Los Angeles, California, USA. The inteview was conducted over the Internet (Zoom) as part of the Health and Human Rights Oral History Project.Sofia Gruskin directs the USC Institute on Inequalities in Global Health (IIGH). She is Professor of Preventive Medicine and Chief of the Disease Prevention, Policy and Global Health Division at the Keck School of Medicine; Professor of Law and Preventive Medicine at the Gould School of Law; and an affiliate faculty member with the Spatial Sciences Institute at the USC Dornsife College of Letters, Arts and Sciences. A pioneer in bringing together multidisciplinary approaches to global health, Gruskin’s work — which ranges from global policy to the grassroots level — has been instrumental in developing the conceptual, methodological and empirical links between health and human rights. In her oral history, she returns to the origins of her work, from which has emerged a long-standing focus on HIV, sexual and reproductive health, child and adolescent health, gender-based violence, non-communicable disease, and health systems. She discusses the central role she played in first conceptualizing and popularizing the application of a human rights framework to health, and how she and her colleagues worked to integrate the concept across governments, civil society, UN agencies, and those in the public health space.
DOI: 10.25549/hhrohp-ouc112194236
title: Sofia Gruskin, interview, Los Angeles, CA, USA, 2022

description: Sofia Gruskin, Los Angeles, California, USA, 2022 September 15, oral history interview, by Maylis Basturk, Los Angeles, California, USA. The inteview was conducted over the Internet (Zoom) as part of the Health and Human Rights Oral History Project.Sofia Gruskin directs the USC Institute on Inequalities in Global Health (IIGH). She is Professor of Preventive Medicine and Chief of the Disease Prevention, Policy and Global Health Division at the Keck School of Medicine; Professor of Law and Preventive Medicine at the Gould School of Law; and an affiliate faculty member with the Spatial Sciences Institute at the USC Dornsife College of Letters, Arts and Sciences. A pioneer in bringing together multidisciplinary approaches to global health, Gruskin’s work — which ranges from global policy to the grassroots level — has been instrumental in developing the conceptual, methodological and empirical links between health and human rights. In her oral history, she returns to the origins of her work, from which has emerged a long-standing focus on HIV, sexual and reproductive health, child and adolescent health, gender-based violence, non-communicable disease, and health systems. She discusses the central role she played in first conceptualizing and popularizing the application of a human rights framework to health, and how she and her colleagues worked to integrate the concept across governments, civil society, UN agencies, and those in the public health space.
DOI: 10.25549/hhrohp-ouc112194231
title: Ruth Morgan Thomas, interview, North Middleton, Scotland, UK, 2022

description: Ruth Morgan Thomas, North Middleton, Scotland, United Kingdom, 2022 June 24, oral history inteview, by Maylis Basturk, Los Angeles, California, USA. The inteview was conducted over the Internet (Zoom) as part of the Health and Human Rights Oral History Project.Ruth Morgan Thomas has fought for the health, rights and dignity of sex workers for more than thirty years: eight years as a sex worker, two and a half years as an academic researcher at Edinburgh University looking at HIV-related risks in the sex industry, and twenty-plus years as a sex workers’ rights advocate within UK, European, and global contexts. She is the outgoing Global Coordinator of the Network of Sex Work Projects (NSWP), and currently co-chairs the UNAIDS Advisory Group on HIV and Sex Work on behalf of the NSWP. In her oral history, she shares the trajectory of her career as an advocate for sex workers, from her first engagement with sex workers' rights, through confrontations with sex-work abolionists and decades of work and learnings as a leading human rights defender.
DOI: 10.25549/hhrohp-ouc112194230
title: Ruth Morgan Thomas, interview, North Middleton, Scotland, UK, 2022

description: Ruth Morgan Thomas, North Middleton, Scotland, United Kingdom, 2022 June 24, oral history inteview, by Maylis Basturk, Los Angeles, California, USA. The inteview was conducted over the Internet (Zoom) as part of the Health and Human Rights Oral History Project.Ruth Morgan Thomas has fought for the health, rights and dignity of sex workers for more than thirty years: eight years as a sex worker, two and a half years as an academic researcher at Edinburgh University looking at HIV-related risks in the sex industry, and twenty-plus years as a sex workers’ rights advocate within UK, European, and global contexts. She is the outgoing Global Coordinator of the Network of Sex Work Projects (NSWP), and currently co-chairs the UNAIDS Advisory Group on HIV and Sex Work on behalf of the NSWP. In her oral history, she shares the trajectory of her career as an advocate for sex workers, from her first engagement with sex workers' rights, through confrontations with sex-work abolionists and decades of work and learnings as a leading human rights defender.
DOI: 10.5281/zenodo.10648128
title: Reptile thermal tolerance breadth
DOI: 10.5281/zenodo.10648129
title: Reptile thermal tolerance breadth