cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.15468/dl.qbcqfm
title: Occurrence Download

description: A dataset containing 2137 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Perca fluviatilis Linnaeus, 1758",
 "Country is New Zealand",
 "HasCoordinate is true"
 ]
}

 The dataset includes 2137 records from 3 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0082826-250525065834625/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.nrumy7
title: Occurrence Download

description: A dataset containing 8947 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Spodoptera litura (Fabricius, 1775)"
 ]
}

 The dataset includes 8947 records from 109 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0082827-250525065834625/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.q5xhvj
title: Occurrence Download

description: A dataset containing 5458 species occurrences available in GBIF matching the query:
{
 "and" : [
 "BasisOfRecord is Human Observation",
 "CoordinateUncertaintyInMeters 0.0-10000.0",
 "Geometry POLYGON((-130.98214 25.41705,-60.28604 25.41705,-60.28604 52.91158,-130.98214 52.91158,-130.98214 25.41705))",
 "TaxonKey is Bromus tectorum L."
 ]
}

 The dataset includes 5458 records from 6 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0082828-250525065834625/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.gwpsng
title: Occurrence Download

description: A dataset containing 2093 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Amniataba percoides (Günther, 1864)",
 "Country is Australia",
 "HasCoordinate is true"
 ]
}

 The dataset includes 2093 records from 22 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0082829-250525065834625/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.q39uxb
title: Occurrence Download

description: A dataset containing 1449 species occurrences available in GBIF matching the query:
{
 "and" : [
 "OccurrenceStatus is Present",
 "TaxonKey is Sceloporus megalepidurus Smith, 1934"
 ]
}

 The dataset includes 1449 records from 37 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0082830-250525065834625/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.6b3dtj
title: Occurrence Download

description: A dataset containing 31350 species occurrences available in GBIF matching the query:
{
 "and" : [
 "BasisOfRecord is Human Observation",
 "TaxonKey is Hyphantria cunea (Drury, 1773)"
 ]
}

 The dataset includes 31350 records from 40 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0082831-250525065834625/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.57783/ad7j-v614
title: LibreChat-DEV
DOI: 10.57783/y22b-pb12
title: LibreChat-TEST
DOI: 10.5281/zenodo.15778895
title: Targeting STK32C suppresses colon cancer progression with combinatorial potential with 5-fluoruracil via HSP90 and PI3K/AKT/mTOR signaling axis

description: Background: In this work, the oncogenic pathogenesis of STK32C was explored in colorectal cancer cells in association with HSP90 and PI3K/AKT/mTOR signaling. 

Methods: TCGA analysis, tissue microarray, next generation sequencing analysis, RNA interference, wound-healing, transwell, MTT, clonogenic, TUNEL and flow cytometry assays, RT-qPCR and Western blotting were employed in HCT116 and SW620 cells transfected with STK32C depletion or overexpression plasmid. Nude mouse tumor model was used to confirm in vitro data. Close interaction between STK32C and HSP90 was investigated by Homology analysis, Co-immunoprecipitation, Coomassie blue staining, GST pulldown assay and immunofluorescence. CompuSyn and SynergyFinder softwares were employed for synergy analysis with 5-Fu

Results: STK32C was highly expressed in HCT116, HT29, SW480, and SW620 cells compared to CCD-18Co fibroblasts with poor prognosis. STK32C depletion exerted cytotoxic, anti-migratory, and anti-invasive effects, inhibited the expression of pro-PARP, pro-Caspase-3, PI3K, p-AKT, p-mTOR, HSP90, and Bcl-2 and increased Bax, sub-G1 population, Annexin V and TUNEL-positive cells in HCT116 and SW620 cells. Also, STK32C depletion enhanced the antitumor activity of 5-FU in HCT116 cells. STK32C binds directly to N-terminal domain of HSP90 by homology, colocalization and binding. Consistently, HSP90 N-terminal inhibitor Ganetespib reduced STK32C and p-AKT1, while the HSP90 C-terminal inhibitor EGCG or AKT inhibitor LY294002 did not affect STK32C. Furthermore, STK32C depletion reduced the growth of HCT116 cells in BALB/c mice with decreased expression of STK32C, HSP90, PCNA, and AKT and activation of caspase 3. 

Conclusions: Targeting STK32C inhibits colorectal cancer progression with combinatorial potential with 5FU via HSP90 and PI3K/AKT/mTOR signaling.
DOI: 10.5281/zenodo.15778896
title: Targeting STK32C suppresses colon cancer progression with combinatorial potential with 5-fluoruracil via HSP90 and PI3K/AKT/mTOR signaling axis

description: Background: In this work, the oncogenic pathogenesis of STK32C was explored in colorectal cancer cells in association with HSP90 and PI3K/AKT/mTOR signaling. 

Methods: TCGA analysis, tissue microarray, next generation sequencing analysis, RNA interference, wound-healing, transwell, MTT, clonogenic, TUNEL and flow cytometry assays, RT-qPCR and Western blotting were employed in HCT116 and SW620 cells transfected with STK32C depletion or overexpression plasmid. Nude mouse tumor model was used to confirm in vitro data. Close interaction between STK32C and HSP90 was investigated by Homology analysis, Co-immunoprecipitation, Coomassie blue staining, GST pulldown assay and immunofluorescence. CompuSyn and SynergyFinder softwares were employed for synergy analysis with 5-Fu

Results: STK32C was highly expressed in HCT116, HT29, SW480, and SW620 cells compared to CCD-18Co fibroblasts with poor prognosis. STK32C depletion exerted cytotoxic, anti-migratory, and anti-invasive effects, inhibited the expression of pro-PARP, pro-Caspase-3, PI3K, p-AKT, p-mTOR, HSP90, and Bcl-2 and increased Bax, sub-G1 population, Annexin V and TUNEL-positive cells in HCT116 and SW620 cells. Also, STK32C depletion enhanced the antitumor activity of 5-FU in HCT116 cells. STK32C binds directly to N-terminal domain of HSP90 by homology, colocalization and binding. Consistently, HSP90 N-terminal inhibitor Ganetespib reduced STK32C and p-AKT1, while the HSP90 C-terminal inhibitor EGCG or AKT inhibitor LY294002 did not affect STK32C. Furthermore, STK32C depletion reduced the growth of HCT116 cells in BALB/c mice with decreased expression of STK32C, HSP90, PCNA, and AKT and activation of caspase 3. 

Conclusions: Targeting STK32C inhibits colorectal cancer progression with combinatorial potential with 5FU via HSP90 and PI3K/AKT/mTOR signaling.
DOI: 10.6084/m9.figshare.29442389
title: <b>Peptide Deformylase Regulates Aldosterone Production through Calbindin 1</b>

description: This is proteomic data for knockdown PDF with lentivirus within H295R cells
DOI: 10.6084/m9.figshare.29442389.v1
title: <b>Peptide Deformylase Regulates Aldosterone Production through Calbindin 1</b>

description: This is proteomic data for knockdown PDF with lentivirus within H295R cells
DOI: 10.15468/dl.4u6jju
title: Occurrence Download

description: A dataset containing 589 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Forsterygion varium (Forster, 1801)",
 "Country is Australia",
 "HasCoordinate is true"
 ]
}

 The dataset includes 589 records from 10 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0082833-250525065834625/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.vtyz53
title: Occurrence Download

description: A dataset containing 5706 species occurrences available in GBIF matching the query:
{
 "and" : [
 "BasisOfRecord is one of (Material sample, Material citation, Specimen, Occurrence evidence)",
 "Continent is one of (North America, South America)",
 "TaxonKey is Scombridae"
 ]
}

 The dataset includes 5706 records from 151 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0082834-250525065834625/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.5281/zenodo.15779046
title: The Impact of the 10 December 2023 ICME Event on Martian Space Environment and Ion Escape Processes: A Multi-fluid Hall-MHD Study
DOI: 10.15468/dl.5szfft
title: Occurrence Download

description: A dataset containing 3148 species occurrences available in GBIF matching the query:
{
 "and" : [
 "BasisOfRecord is one of (Material sample, Material citation, Specimen, Occurrence evidence)",
 "Continent is one of (North America, South America)",
 "TaxonKey is Stromateidae"
 ]
}

 The dataset includes 3148 records from 113 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0082837-250525065834625/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.wr8qky
title: Occurrence Download

description: A dataset containing 208 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Rhinella marina (Linnaeus, 1758)",
 "Country is Dominican Republic",
 "HasCoordinate is true"
 ]
}

 The dataset includes 208 records from 7 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0082840-250525065834625/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.cswuhy
title: Occurrence Download

description: A dataset containing 79 species occurrences available in GBIF matching the query:
{
 "and" : [
 "OccurrenceStatus is Present",
 "TaxonKey is Sceloporus subpictus Lynch & Smith, 1965"
 ]
}

 The dataset includes 79 records from 16 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0082841-250525065834625/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.472aeq
title: Occurrence Download

description: A dataset containing 12350 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Agrostis capillaris L.",
 "Geometry POLYGON((-8.00174339329464 54.1998526673513, 0.202120938926891 54.1998526673513, 0.202120938926891 61.2628565887411, -8.00174339329464 61.2628565887411, -8.00174339329464 54.1998526673513))",
 "CoordinateUncertaintyInMeters is 0,101",
 "HasCoordinate is true",
 "HasGeospatialIssue is false"
 ]
}

 The dataset includes 12350 records from 51 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0082836-250525065834625/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.xz9y6m
title: Occurrence Download

description: A dataset containing 48 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Rhinella marina (Linnaeus, 1758)",
 "Country is Barbados",
 "HasCoordinate is true"
 ]
}

 The dataset includes 48 records from 4 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0082839-250525065834625/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.tma3b3
title: Occurrence Download

description: A dataset containing 37448 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Rhinella marina (Linnaeus, 1758)",
 "Country is Australia",
 "HasCoordinate is true"
 ]
}

 The dataset includes 37448 records from 38 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0082838-250525065834625/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.5281/zenodo.15779036
title: Labile Carbon Promotes Nitrous Oxide Uptake in Cropland Soils
DOI: 10.5281/zenodo.15779037
title: Labile Carbon Promotes Nitrous Oxide Uptake in Cropland Soils
DOI: 10.15468/dl.455vmx
title: Occurrence Download

description: A dataset containing 440 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Phellodon tomentosus (L.) Banker",
 "Geometry POLYGON((-8.00174339329464 54.1998526673513, 0.202120938926891 54.1998526673513, 0.202120938926891 61.2628565887411, -8.00174339329464 61.2628565887411, -8.00174339329464 54.1998526673513))",
 "CoordinateUncertaintyInMeters is 0,101",
 "HasCoordinate is true",
 "HasGeospatialIssue is false"
 ]
}

 The dataset includes 440 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0082842-250525065834625/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.uuw3cr
title: Occurrence Download

description: A dataset containing 337 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Rhinella marina (Linnaeus, 1758)",
 "Country is Fiji",
 "HasCoordinate is true"
 ]
}

 The dataset includes 337 records from 9 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0082844-250525065834625/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.hur6gu
title: Occurrence Download

description: A dataset listing the 22 species recorded in GBIF matching the query:
{
 "and" : [
 "Geometry MULTIPOLYGON(((-75.55911 4.95011,-75.56004 4.94893,-75.55728 4.94134,-75.55645 4.92413,-75.54995 4.9244,-75.54269 4.92828,-75.54097 4.92018,-75.53671 4.91646,-75.52841 4.91754,-75.52179 4.92329,-75.51119 4.92419,-75.50754 4.92305,-75.5037 4.91873,-75.49458 4.92024,-75.48058 4.91515,-75.4833 4.91038,-75.47852 4.90465,-75.47358 4.90356,-75.47436 4.8966,-75.47241 4.89052,-75.46763 4.88783,-75.46294 4.88753,-75.46457 4.89078,-75.46178 4.9018,-75.46585 4.91238,-75.47221 4.91666,-75.47312 4.91889,-75.47702 4.91897,-75.47625 4.91547,-75.48215 4.92332,-75.48064 4.92578,-75.4772 4.92329,-75.47685 4.9244,-75.48993 4.93192,-75.49392 4.92823,-75.49062 4.93508,-75.49223 4.93598,-75.4964 4.93192,-75.50011 4.93187,-75.50268 4.92932,-75.50569 4.9351,-75.50363 4.93647,-75.5067 4.93694,-75.50696 4.93385,-75.50892 4.93285,-75.5137 4.93649,-75.51051 4.94032,-75.51242 4.94195,-75.52412 4.94409,-75.52901 4.94765,-75.52766 4.93889,-75.53065 4.9297,-75.53151 4.92874,-75.53615 4.93139,-75.54162 4.93074,-75.54261 4.93766,-75.5469 4.94103,-75.5474 4.94377,-75.55911 4.95011)))",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 "TaxonKey is Plantae"
 ]
}

 The dataset's 22 records were derived from 3 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0082832-250525065834625/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.s7bub4
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Rhinella marina (Linnaeus, 1758)",
 "Country is Egypt",
 "HasCoordinate is true"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0082843-250525065834625/datasets/export for details.
DOI: 10.5281/zenodo.15779055
title: THE PRACTICAL ESSENCE OF SIMULTANEOUS INTERPRETING
DOI: 10.5281/zenodo.15779056
title: THE PRACTICAL ESSENCE OF SIMULTANEOUS INTERPRETING
DOI: 10.15468/dl.b7sur9
title: Occurrence Download

description: A dataset containing 256505 species occurrences available in GBIF matching the query:
{
 "DatasetKey" : [
 "is WELT Herbarium at Museum of New Zealand Te Papa Tongarewa"
 ]
}

 The dataset includes 256505 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0082835-250525065834625/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.5281/zenodo.15779058
title: weecology/EvergladesWadingBird: 1.79.0

description: v1.79.0
DOI: 10.15468/dl.m73egc
title: Occurrence Download

description: A dataset containing 64 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Rhinella marina (Linnaeus, 1758)",
 "Country is Haiti",
 "HasCoordinate is true"
 ]
}

 The dataset includes 64 records from 3 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0082846-250525065834625/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.ujwgxa
title: Occurrence Download

description: A dataset containing 124 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Rhinella marina (Linnaeus, 1758)",
 "Country is Jamaica",
 "HasCoordinate is true"
 ]
}

 The dataset includes 124 records from 5 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0082848-250525065834625/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.26180/22133105.v6
title: The DREAM database

description: Overview
The Dream EEG and Mentation (DREAM) database collects and stores metadata about DREAM datasets, and is accessible to the public. DREAM datasets provide polysomnography and associated subjective mentation reports. Some datasets may also contain personally identifiable information about participants, but such information are not stored by the DREAM database.
Datasets are contributed to DREAM from many different labs in many different studies and, where possible, made openly accessible in the hope of pushing the fields of sleep, dream, brain-computer interface, and consciousness research forward. If you have data that others in the community might find useful, please consider contributing it to DREAM.
Contents
The DREAM database consists of a following data tables:

 Datasets
 Data records
 People

The records in <em>Datasets</em> list all officially accepted DREAM datasets and their summary metadata. <em>Data records</em> lists metadata of each individual datum from these datasets. <em>People</em> provides information on the data contributors, referred to by <em>Key ID</em> in <em>Datasets</em>.
DOI: 10.15468/dl.97urka
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Rhinella marina (Linnaeus, 1758)",
 "Country is Indonesia",
 "HasCoordinate is true"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0082847-250525065834625/datasets/export for details.
DOI: 10.5281/zenodo.15779061
title: AN ALGORITHM FOR PREDICTING COMPLICATIONS IN TOXIC ALCOHOLIC LIVER DAMAGE
DOI: 10.5281/zenodo.15779062
title: AN ALGORITHM FOR PREDICTING COMPLICATIONS IN TOXIC ALCOHOLIC LIVER DAMAGE
DOI: 10.15468/dl.e42gy9
title: Occurrence Download

description: A dataset containing 35 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Rhinella marina (Linnaeus, 1758)",
 "Country is Japan",
 "HasCoordinate is true"
 ]
}

 The dataset includes 35 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0082850-250525065834625/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.gb2ux5
title: Occurrence Download

description: A dataset containing 97 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is China",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "TaxonKey is Cedrus deodara (Lamb.) G.Don"
 ]
}

 The dataset includes 97 records from 10 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0082851-250525065834625/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.tnfs3y
title: Occurrence Download

description: A dataset containing 445 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Rhinella marina (Linnaeus, 1758)",
 "Country is Papua New Guinea",
 "HasCoordinate is true"
 ]
}

 The dataset includes 445 records from 18 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0082853-250525065834625/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.uz69bw
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Rhinella marina (Linnaeus, 1758)",
 "Country is Mauritius",
 "HasCoordinate is true"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0082852-250525065834625/datasets/export for details.
DOI: 10.15468/dl.492dpn
title: Occurrence Download

description: A dataset containing 1164 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Rhinella marina (Linnaeus, 1758)",
 "Country is Philippines",
 "HasCoordinate is true"
 ]
}

 The dataset includes 1164 records from 14 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0082855-250525065834625/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.6864q8
title: Occurrence Download

description: A dataset containing 4724 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Hypnum jutlandicum Holmen & E.Warncke",
 "Geometry POLYGON((-8.00174339329464 54.1998526673513, 0.202120938926891 54.1998526673513, 0.202120938926891 61.2628565887411, -8.00174339329464 61.2628565887411, -8.00174339329464 54.1998526673513))",
 "CoordinateUncertaintyInMeters is 0,101",
 "HasCoordinate is true",
 "HasGeospatialIssue is false"
 ]
}

 The dataset includes 4724 records from 32 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0082854-250525065834625/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.3886/e234462v1
title: ECIN Replication Package for "The Economic Effects of Long-Term Climate Change: Evidence from the Little Ice Age: Replication"

description: Code for "The Economic Effects of Long-Term Climate Change: Evidence from the Little Ice Age: Replication" <br><br>Data is exactly the same as, and publicly available from, the original article "The Economic Effects of Long-Term Climate Change: Evidence from the Little Ice Age"