cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.1626661.v1
title: Health state utility values associated with advanced gastric, oesophageal, or gastro-oesophageal junction adenocarcinoma: a systematic review

description: Objectives:To systematically identify utility values associated with advanced gastric cancer (GC), oesophageal cancer (OC), or gastro-oesophageal junction (GEJ) cancer. Utility values relating to health states are an essential component for cost-utility analysis (CUA).Methods:MEDLINE, Embase, Cochrane Library, and EconLit databases were reviewed for relevant studies using a pre-defined search strategy. Studies eligible for inclusion reported health state utility values (HSUVs) using direct (standard gamble [SG] and time-trade-off [TTO]) and indirect (such as EuroQol 5D [EQ-5D], short-form 6D [SF-6D], and the 15-dimensional instrument [15D]) methods for patients with advanced GC, OC, or GEJ cancer.Results:A total of 539 unique publications were identified, of which eight met the inclusion criteria (GC, <i>n</i> = 2; mixed population [gastrointestinal cancers], <i>n</i> = 4; OC, <i>n</i> = 2). The most commonly used instrument to estimate HSUVs was the EQ-5D (<i>n</i> = 7). Utilities were also estimated using the SF-6D and the 15D in the same study (<i>n</i> = 1). Direct elicitation methods included the TTO (<i>n</i> = 2) and SG (<i>n</i> = 1). Across the eight identified publications<i>,</i> health states and study populations were heterogeneous and sample sizes were limited.Limitations:This review, as with all summaries of this nature, is only as robust as the data derived from the identified studies. The systematic review process does not resolve any design issues or biases associated with the original studies.Conclusions:Limited data estimate HSUVs in patients with advanced GC, OC<i>,</i> or GEJ cancer. Utilities for advanced GC alone and advanced OC alone were reported in only two publications for each cancer type. No publications considered advanced GEJ utilities alone, and four publications considered utilities for a mixed population of gastrointestinal cancer types. Comparisons are confounded by heterogeneity across the identified publications. Further research into HSUVs associated with advanced GC and OC is required to improve the evidence available for use in CUAs.
DOI: 10.6084/m9.figshare.1626655
title: Mapping epitopes of U1-70K autoantibodies at single-amino acid resolution

description: The mechanisms underlying development of ribonucleoprotein (RNP) autoantibodies are unclear. The U1-70K protein is the predominant target of RNP autoantibodies, and the RNA binding domain has been shown to be the immunodominant autoantigenic region of U1-70K, although the specific epitopes are not known. To precisely map U1-70K epitopes, we developed silicon-based peptide microarrays with &gt;5700 features, corresponding to 843 unique peptides derived from the U1-70K protein. The microarrays feature overlapping peptides, with single-amino acid resolution in length and location, spanning amino acids 110–170 within the U1-70K RNA binding domain. We evaluated the serum IgG of a cohort of patients with systemic lupus erythematosus (SLE; <i>n</i> = 26) using the microarrays, and identified multiple reactive epitopes, including peptides 116–121 and 143–148. Indirect peptide ELISA analysis of the sera of patients with SLE (<i>n</i> = 88) revealed that ∼14% of patients had serum IgG reactivity to 116–121, while reactivity to 143–148 appeared to be limited to a single patient. SLE patients with serum reactivity to 116–121 had significantly lower SLE Disease Activity Index (SLEDAI) scores at the time of sampling, compared to non-reactive patients. Minimal reactivity to the peptides was observed in the sera of healthy controls (<i>n</i> = 92). Competitive ELISA showed antibodies to 116–121 bind a common epitope in U1-70K (68–72) and the matrix protein M1 of human influenza B viruses. Institutional Review Boards approved this study. Knowledge of the precise epitopes of U1-70K autoantibodies may provide insight into the mechanisms of development of anti-RNP, identify potential clinical biomarkers and inform ongoing clinical trails of peptide-based therapeutics.
DOI: 10.6084/m9.figshare.1626657
title: A PCT algorithm for discontinuation of antibiotic therapy is a cost-effective way to reduce antibiotic exposure in adult intensive care patients with sepsis

description: Objective:Procalcitonin (PCT) is a specific marker for differentiating bacterial from non-infective causes of inflammation. It can be used to guide initiation and duration of antibiotic therapy in intensive care unit (ICU) patients with suspected sepsis, and might reduce the duration of hospital stay. Limiting antibiotic treatment duration is highly important because antibiotic over-use may cause patient harm, prolonged hospital stay, and resistance development. Several systematic reviews show that a PCT algorithm for antibiotic discontinuation is safe, but upfront investment required for PCT remains an important barrier against implementation. The current study investigates to what extent this PCT algorithm is a cost-effective use of scarce healthcare resources in ICU patients with sepsis compared to current practice.Methods:A decision tree was developed to estimate the health economic consequences of the PCT algorithm for antibiotic discontinuation from a Dutch hospital perspective. Input data were obtained from a systematic literature review. When necessary, additional information was gathered from open interviews with clinical chemists and intensivists. The primary effectiveness measure is defined as the number of antibiotic days, and cost-effectiveness is expressed as incremental costs per antibiotic day avoided.Results:The PCT algorithm for antibiotic discontinuation is expected to reduce hospital spending by circa €3503 per patient, indicating savings of 9.2%. Savings are mainly due to reductions in length of hospital stay, number of blood cultures performed, and, importantly, days on antibiotic therapy. Probabilistic and one-way sensitivity analyses showed the model outcome to be robust against changes in model inputs.Conclusion:Proven safe, a PCT algorithm for antibiotic discontinuation is a cost-effective means of reducing antibiotic exposure in adult ICU patients with sepsis, compared to current practice. Additional resources required for PCT are more than offset by downstream cost savings. This finding is highly important given the aim of preventing widespread antibiotic resistance.
DOI: 10.6084/m9.figshare.1626657.v1
title: A PCT algorithm for discontinuation of antibiotic therapy is a cost-effective way to reduce antibiotic exposure in adult intensive care patients with sepsis

description: Objective:Procalcitonin (PCT) is a specific marker for differentiating bacterial from non-infective causes of inflammation. It can be used to guide initiation and duration of antibiotic therapy in intensive care unit (ICU) patients with suspected sepsis, and might reduce the duration of hospital stay. Limiting antibiotic treatment duration is highly important because antibiotic over-use may cause patient harm, prolonged hospital stay, and resistance development. Several systematic reviews show that a PCT algorithm for antibiotic discontinuation is safe, but upfront investment required for PCT remains an important barrier against implementation. The current study investigates to what extent this PCT algorithm is a cost-effective use of scarce healthcare resources in ICU patients with sepsis compared to current practice.Methods:A decision tree was developed to estimate the health economic consequences of the PCT algorithm for antibiotic discontinuation from a Dutch hospital perspective. Input data were obtained from a systematic literature review. When necessary, additional information was gathered from open interviews with clinical chemists and intensivists. The primary effectiveness measure is defined as the number of antibiotic days, and cost-effectiveness is expressed as incremental costs per antibiotic day avoided.Results:The PCT algorithm for antibiotic discontinuation is expected to reduce hospital spending by circa €3503 per patient, indicating savings of 9.2%. Savings are mainly due to reductions in length of hospital stay, number of blood cultures performed, and, importantly, days on antibiotic therapy. Probabilistic and one-way sensitivity analyses showed the model outcome to be robust against changes in model inputs.Conclusion:Proven safe, a PCT algorithm for antibiotic discontinuation is a cost-effective means of reducing antibiotic exposure in adult ICU patients with sepsis, compared to current practice. Additional resources required for PCT are more than offset by downstream cost savings. This finding is highly important given the aim of preventing widespread antibiotic resistance.
DOI: 10.6084/m9.figshare.1626652
title: Displaying Variation in Large Datasets: Plotting a Visual Summary of Effect Sizes

description: Displaying the component-wise between-group differences high-dimensional datasets is problematic because widely used plots such as Bland–Altman and Volcano plots do not show what they are colloquially <i>believed</i> to show. Thus, it is difficult for the experimentalist to grasp why the between-group difference of one component is “significant” while that of another component is not. Here, we propose a type of “Effect Plot” that displays between-group differences in relation to respective underlying variability for every component of a high-dimensional dataset. We use synthetic data to show that such a plot captures the essence of what determines “significance” for between-group differences in each component, and provide guidance in the interpretation of the plot. Supplementary online materials contain the code and data for this article and include simple R functions to produce an effect plot from suitable datasets.
DOI: 10.6084/m9.figshare.1626655.v1
title: Mapping epitopes of U1-70K autoantibodies at single-amino acid resolution

description: The mechanisms underlying development of ribonucleoprotein (RNP) autoantibodies are unclear. The U1-70K protein is the predominant target of RNP autoantibodies, and the RNA binding domain has been shown to be the immunodominant autoantigenic region of U1-70K, although the specific epitopes are not known. To precisely map U1-70K epitopes, we developed silicon-based peptide microarrays with &gt;5700 features, corresponding to 843 unique peptides derived from the U1-70K protein. The microarrays feature overlapping peptides, with single-amino acid resolution in length and location, spanning amino acids 110–170 within the U1-70K RNA binding domain. We evaluated the serum IgG of a cohort of patients with systemic lupus erythematosus (SLE; <i>n</i> = 26) using the microarrays, and identified multiple reactive epitopes, including peptides 116–121 and 143–148. Indirect peptide ELISA analysis of the sera of patients with SLE (<i>n</i> = 88) revealed that ∼14% of patients had serum IgG reactivity to 116–121, while reactivity to 143–148 appeared to be limited to a single patient. SLE patients with serum reactivity to 116–121 had significantly lower SLE Disease Activity Index (SLEDAI) scores at the time of sampling, compared to non-reactive patients. Minimal reactivity to the peptides was observed in the sera of healthy controls (<i>n</i> = 92). Competitive ELISA showed antibodies to 116–121 bind a common epitope in U1-70K (68–72) and the matrix protein M1 of human influenza B viruses. Institutional Review Boards approved this study. Knowledge of the precise epitopes of U1-70K autoantibodies may provide insight into the mechanisms of development of anti-RNP, identify potential clinical biomarkers and inform ongoing clinical trails of peptide-based therapeutics.
DOI: 10.6084/m9.figshare.1626652.v1
title: Displaying Variation in Large Datasets: Plotting a Visual Summary of Effect Sizes

description: Displaying the component-wise between-group differences high-dimensional datasets is problematic because widely used plots such as Bland–Altman and Volcano plots do not show what they are colloquially <i>believed</i> to show. Thus, it is difficult for the experimentalist to grasp why the between-group difference of one component is “significant” while that of another component is not. Here, we propose a type of “Effect Plot” that displays between-group differences in relation to respective underlying variability for every component of a high-dimensional dataset. We use synthetic data to show that such a plot captures the essence of what determines “significance” for between-group differences in each component, and provide guidance in the interpretation of the plot. Supplementary online materials contain the code and data for this article and include simple R functions to produce an effect plot from suitable datasets.
DOI: 10.6084/m9.figshare.1626645
title: New material of <i>Seggeurius amourensis</i> (Paenungulata, Hyracoidea), including a partial skull with intact basicranium

description: <i>Seggeurius</i> is the basal-most hyracoid known to date, and one of the earliest known fossil afrotherians. This taxon has a dramatic importance in mammalian phylogeny, but until now it was known from dental remains only. Here we describe previously unpublished material of <i>Seggeurius</i>, including some mandibular and maxillary fragments, and a braincase. This study is the first to thoroughly describe and discuss the morphology of the ear region and osseous inner ear of a Paleogene hyracoid. It allows a reappraisal of some important characters that are often used in cladistic analyses of Paenungulata. In particular, it seems that in stem hyracoids the orbit is located caudally, the eustachian sac is absent or reduced, the course of the internal carotid artery is intrabullar and medial, and a deep epitympanic sinus, a basisphenoid contribution to the bulla, and the stapedial artery are present. The cochlear canal is rather flattened, and the secondary common crus was rapidly lost. A cladistic analysis of stem placental mammals highlights three derived traits shared by <i>Seggeurius</i> and stem sirenians (the tuber-shaped postglenoid process, the squared and massive mastoid apophysis of the petrosal, and the presence of a swelling on the septum metacochleare) and supports molecular analysis that hypothesizes a Hyracoidea-Sirenia sister-group relationship. This study demonstrates how useful the petrosal and labyrinthine characters of fossils can be for mammalian phylogenetic inference. SUPPLEMENTAL DATA—Supplemental materials are available for this article for free at www.tandfonline.com/UJVP Citation for this article: Benoit, J., J.-Y. Crochet, M. Mahboubi, J.-J. Jaeger, M. Bensalah, M. Adaci, and R. Tabuce. 2015. New material of <i>Seggeurius amourensis</i> (Paenungulata, Hyracoidea), including a partial skull with intact basicranium. Journal of Vertebrate Paleontology. DOI: 10.1080/02724634.2015.1034358.
DOI: 10.6084/m9.figshare.1626645.v1
title: New material of <i>Seggeurius amourensis</i> (Paenungulata, Hyracoidea), including a partial skull with intact basicranium

description: <i>Seggeurius</i> is the basal-most hyracoid known to date, and one of the earliest known fossil afrotherians. This taxon has a dramatic importance in mammalian phylogeny, but until now it was known from dental remains only. Here we describe previously unpublished material of <i>Seggeurius</i>, including some mandibular and maxillary fragments, and a braincase. This study is the first to thoroughly describe and discuss the morphology of the ear region and osseous inner ear of a Paleogene hyracoid. It allows a reappraisal of some important characters that are often used in cladistic analyses of Paenungulata. In particular, it seems that in stem hyracoids the orbit is located caudally, the eustachian sac is absent or reduced, the course of the internal carotid artery is intrabullar and medial, and a deep epitympanic sinus, a basisphenoid contribution to the bulla, and the stapedial artery are present. The cochlear canal is rather flattened, and the secondary common crus was rapidly lost. A cladistic analysis of stem placental mammals highlights three derived traits shared by <i>Seggeurius</i> and stem sirenians (the tuber-shaped postglenoid process, the squared and massive mastoid apophysis of the petrosal, and the presence of a swelling on the septum metacochleare) and supports molecular analysis that hypothesizes a Hyracoidea-Sirenia sister-group relationship. This study demonstrates how useful the petrosal and labyrinthine characters of fossils can be for mammalian phylogenetic inference. SUPPLEMENTAL DATA—Supplemental materials are available for this article for free at www.tandfonline.com/UJVP Citation for this article: Benoit, J., J.-Y. Crochet, M. Mahboubi, J.-J. Jaeger, M. Bensalah, M. Adaci, and R. Tabuce. 2015. New material of <i>Seggeurius amourensis</i> (Paenungulata, Hyracoidea), including a partial skull with intact basicranium. Journal of Vertebrate Paleontology. DOI: 10.1080/02724634.2015.1034358.
DOI: 10.6084/m9.figshare.1626651.v1
title: Technical Note: Cost Estimation Using ANFIS

description: Cost function estimation is vital for decision making in project management. In this paper, a novel cost estimator is investigated based on adaptive neuro-fuzzy inference system (ANFIS). In the numerical studies, ANFIS is tested to modeling pressure vessel cost as a case study. According to the comparative results, ANFIS shows better accuracy than multiple linear regression (MLR), taylor kriging (TK) and artificial neural network (ANN). Hence, ANFIS can be applicable to various cost function estimation problems.
DOI: 10.6084/m9.figshare.1626651
title: Cost estimation using ANFIS

description: Cost function estimation is vital for decision-making in project management. In this article, a novel cost estimator is investigated based on an adaptive neuro-fuzzy inference system (ANFIS). In the numerical studies, ANFIS is tested to modeling pressure vessel cost as a case study. According to the comparative results, ANFIS shows better accuracy than multiple linear regression (MLR), Taylor Kriging (TK), and artificial neural networks (ANNs). Hence, ANFIS can be applicable to various cost function estimation problems.
DOI: 10.6084/m9.figshare.1626642
title: A high-latitude dromaeosaurid, <i>Boreonykus certekorum</i>, gen. et sp. nov. (Theropoda), from the upper Campanian Wapiti Formation, west-central Alberta

description: Dromaeosaurids were rare components of most Late Cretaceous terrestrial ecosystems and are poorly known from high palaeolatitudes. New dromaeosaurid material, including a frontal and associated postcranial elements, is described from a dense monodominant ceratopsid bonebed on Pipestone Creek, near the city of Grande Prairie (Unit 3, Wapiti Formation, upper Campanian), central-western Alberta, Canada. This stratigraphic interval is significant because it records a period of terrestrial deposition at a time when much of the western interior of Canada and the United States was inundated by the Bearpaw Sea. A phylogenetic analysis recovers <i>Boreonykus certekorum</i>, gen. et sp. nov., as a derived eudromaeosaur, possibly within Velociraptorinae. The identification of a new dromaeosaurid from the Wapiti Formation simultaneously helps fill an important gap in the record of late Campanian dromaeosaurids, bolsters support for a partly endemic fauna within the Wapiti Formation, and potentially adds to the North American record of a predominantly Asian Velociraptorinae. http://zoobank.org/urn:lsid:zoobank.org:pub:8A64DF33-58C3-4C43-830E-78F725094A13 SUPPLEMENTAL DATA—Supplemental materials are available for this article for free at www.tandfonline.com/UJVP Citation for this article: Bell, P. R., and P. J. Currie. 2015. A high-latitude dromaeosaurid, <i>Boreonykus certekorum</i>, gen. et sp. nov. (Theropoda), from the upper Campanian Wapiti Formation, west-central Alberta. Journal of Vertebrate Paleontology. DOI: 10.1080/02724634.2015.1034359.
DOI: 10.6084/m9.figshare.1626651.v3
title: Cost estimation using ANFIS

description: Cost function estimation is vital for decision-making in project management. In this article, a novel cost estimator is investigated based on an adaptive neuro-fuzzy inference system (ANFIS). In the numerical studies, ANFIS is tested to modeling pressure vessel cost as a case study. According to the comparative results, ANFIS shows better accuracy than multiple linear regression (MLR), Taylor Kriging (TK), and artificial neural networks (ANNs). Hence, ANFIS can be applicable to various cost function estimation problems.
DOI: 10.6084/m9.figshare.1626640
title: Efficient and convenient synthesis, characterization, and antimicrobial evaluation of some new tetracyclic 1,4-benzothiazines

description: In the present study, 20 new tetracyclic 1,4-benzothiazines (<b>4a</b>–<b>4 t</b>) were conveniently synthesized in good yields and characterized by different spectral and physical techniques. The in vitro antimicrobial evaluation of the synthesized benzothiazine derivatives was performed by serial dilution against two Gram-positive bacteria [<i>Bacillus subtilis</i> (MTCC 441) and <i>Staphylococcus epidermidis</i> (MTCC 6880)], two Gram-negative bacteria [<i>Escherichia coli</i> (MTCC 1652) and <i>Pseudomonas aeruginosa</i> (MTCC 424)], and two fungal strains [<i>Candida albicans</i> (MTCC 227) and <i>Aspergillus niger</i> (MTCC 8189)]. The derivatives <b>4 l</b> and <b>4 t</b> were found to be more potent than standard drug, i.e., fluconazole, against <i>A. niger</i> and <i>C. albicans</i>, respectively.
DOI: 10.6084/m9.figshare.1626642.v1
title: A high-latitude dromaeosaurid, <i>Boreonykus certekorum</i>, gen. et sp. nov. (Theropoda), from the upper Campanian Wapiti Formation, west-central Alberta

description: Dromaeosaurids were rare components of most Late Cretaceous terrestrial ecosystems and are poorly known from high palaeolatitudes. New dromaeosaurid material, including a frontal and associated postcranial elements, is described from a dense monodominant ceratopsid bonebed on Pipestone Creek, near the city of Grande Prairie (Unit 3, Wapiti Formation, upper Campanian), central-western Alberta, Canada. This stratigraphic interval is significant because it records a period of terrestrial deposition at a time when much of the western interior of Canada and the United States was inundated by the Bearpaw Sea. A phylogenetic analysis recovers <i>Boreonykus certekorum</i>, gen. et sp. nov., as a derived eudromaeosaur, possibly within Velociraptorinae. The identification of a new dromaeosaurid from the Wapiti Formation simultaneously helps fill an important gap in the record of late Campanian dromaeosaurids, bolsters support for a partly endemic fauna within the Wapiti Formation, and potentially adds to the North American record of a predominantly Asian Velociraptorinae. http://zoobank.org/urn:lsid:zoobank.org:pub:8A64DF33-58C3-4C43-830E-78F725094A13 SUPPLEMENTAL DATA—Supplemental materials are available for this article for free at www.tandfonline.com/UJVP Citation for this article: Bell, P. R., and P. J. Currie. 2015. A high-latitude dromaeosaurid, <i>Boreonykus certekorum</i>, gen. et sp. nov. (Theropoda), from the upper Campanian Wapiti Formation, west-central Alberta. Journal of Vertebrate Paleontology. DOI: 10.1080/02724634.2015.1034359.
DOI: 10.6084/m9.figshare.1626651.v2
title: Technical note: Cost estimation using ANFIS

description: Cost function estimation is vital for decision making in project management. In this paper, a novel cost estimator is investigated based on adaptive neuro-fuzzy inference system (ANFIS). In the numerical studies, ANFIS is tested to modeling pressure vessel cost as a case study. According to the comparative results, ANFIS shows better accuracy than multiple linear regression (MLR), taylor kriging (TK) and artificial neural network (ANN). Hence, ANFIS can be applicable to various cost function estimation problems.