cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.25442/hku.14762208.v1
title: Supporting data for "Transmembrane protein VMP1 dysregulation in modulating tumour growth and angiogenesis in glioblastoma"

description: This dataset contains data determining the upregulation of VMP1 in glioblastoma compared to normal brain tissues using two publicly available microarray datasets CGGA and TCGA and the candidate’s cohort of clinical specimens. Moreover, Kaplan Meier survival, Cox proportional hazard regression and receiver operating curve analyses revealed that VMP1 could serve as an independent diagnostic and prognostic biomarker for glioma patients. Functional characterization of VMP1 was then performed with loss- and gain-of-function studies and found that VMP1 exerted oncogenic effects on GBM growth in vivo but not in vitro. The inconsistency between in vitro and in vivo findings suggested that VMP1-mediated oncogenic effects might be dependent on a three-dimensional microenvironment. Bioinformatic analysis predicted that VMP1 dysregulation could be associated with altered extracellular matrix (ECM)- receptor interaction and angiogenesis in GBM. Concertedly, direct forced expression of VMP1 was associated with significant increases in the diameter of GBM spheroids in ECM-coated cell culture and the number and diameter of blood vessels in both subcutaneous and intracranial xenografts. Moreover, VMP1-overexpressing cells-derived soluble pro-angiogenic factors were found to activate the angiogenic switch in endothelial cells in both ECM dependent and -independent manners possibly via β-catenin and LOX-mediated signaling pathways, which in turn conferred growth advantage in GBM cells.
DOI: 10.14457/cu.the.1984.29
title: ผลของการใช้ตัวยึดเกาะชนิดต่างๆ ในสูตรยาเม็ด Sulfathiazole
DOI: 10.14457/cu.the.1984.30
title: ผลของการเข้าร่วมกลุ่มจิตสัมพันธ์ต่อความเจริญส่วนบุคคล
DOI: 10.14457/cu.the.1985.4
title: การศึกษาปัญหาและอุปสรรคในการนำกลุ่มคุณภาพมาใช้ ในธุรกิจอุตสาหกรรมการผลิตของประเทศไทย
DOI: 10.14457/cu.the.1985.5
title: การพัฒนาระบบเก็บข้อมูลของเครื่องร่างแผนที่จากภาพถ่ายทางอากา
DOI: 10.14457/cu.the.2004.1435
title: Study of a synthetic method and application of high surface area titania and TS-1 zeolite in photocatalytic membrane reactor
DOI: 10.14457/cu.the.2004.1437
title: Catalytic esterification of candida antarctica lipase B and thermomyces lanuginosa lipase encapsulated in sodium bis(2-ethylhexyl) phosphate reverse micellar system
DOI: 10.14457/tu.the.2019.1476
title: The effects of the reciprocal teaching procedure on Thai high school students’ English reading performance and use of metacognitive reading strategies

description: The purpose of this study was to investigate the effects of the Reciprocal Teaching Procedure (RTP) on Thai high school students’ English reading performance in responding to text-explicit, text-implicit and script-implicit questions, use of metacognitive reading strategies and their attitudes towards the RTP. The present investigation was an experimental study with a pretest-posttest control-group design. The participants were 44 tenth grade students studying at a high school in a province in the north of Thailand. They enrolled in an elective course called English Reading II (ENG31202) in the second semester of the academic year 2017. They received training for 50 minutes twice a week for 14 weeks and were measured for question response accuracy using 6 reading performance tests. The mixed methods study was applied to investigate the use of metacognitive reading strategies. Several sources of data included the Survey of Reading Strategies (SORS), think-aloud sessions, and interviews. They were administered an attitude questionnaire a day after the final day of the intervention. In addition, student interviews were conducted. Data were analyzed using multivariate analysis with testing time as the repeated dimension. The results indicated that the RTP did appear to positively affect Thai high school students’ English reading performance in responding to text-explicit, text-implicit and script-implicit questions. Over the period of the implementation, the mean scores from the six tests increased. In the case of text-implicit questions, the students’ mean scores for testing occasion 6 was higher than that for testing occasion 5. Yet, the difference is not statistically significant. The students scored higher over testing occasions on text-implicit and script-implicit questions. The findings indicated that the students’ use of metacognitive reading strategies was significantly higher after the implementation of the RTP at the .05 level of confidence. The most frequently used metacognitive reading strategies were Problem Solving Strategies (PROB), followed by Global Reading Strategies (GLOB), and then Support Reading Strategies (SUB). The results from the questionnaire and interviews showed that Thai high school students had positive attitudes towards the RTP. The students strongly believed that the RTP provided them with benefits. They were satisfied with the RTP because it helped them improve their reading performance. The results from the interviews confirm the results from the questionnaire and reinforce the positive impact that the RTP has had on the students reading ability.
DOI: 10.14457/tu.the.2019.1477
title: Ideologies presented in social studies textbooks used in English program and bilingual schools

description: Construction of shared patriotic ideas and sentiments can ensure a nation’s harmony and cooperation. Ideology is often rooted in formal education. Ideally, education must be presented as neutral and child-centered, but we all know that identity construction through education is values-oriented in varying degrees. Children’s identities may be shaped through resonation of ideals and traditions established as important in the curricula, seen mostly in social studies. Social studies textbooks, therefore, can be a source and record of political and cultural regulation designated by the powerful group in the society. Thailand, a country where stability appears to be a commodity in short, has witnessed conflicts between classes, political affiliations and ideological beliefs for decades. Recently, despite the military regime, in the wake of openness towards world cultures, discourse of human dignity has been firmly taking root in public. Critical questions have been addressed against conventions and traditions. This study joins the movement.It investigates ideologies in social studies textbooks endorsed to be used in bilingual and international schools (grades 1 to 6) in Thailand. Bringing together the notions of ideology and content analysis, I focus on identifying lexical items and phrases indicating positioning of children according to their practices in specific context. The analyses of linguistic evidence can reveal what ideological moralities are constructed through formal education and how they are made to enforce particular agendas with prioritization of social conformity.
DOI: 10.14457/tu.the.2019.1478
title: Intercultural communication perspectives on international teamwork: a case study of Singaporean-Thai corporate staff

description: This research is the application of an intercultural communication framework in the internationalteamwork of Singaporean and Thai staff in a Singaporean-Thai corporate. The main objective of the studywas to explore two aspects: the intercultural communication patterns that were reported to be used inteamwork, and the perspectives of teamwork of Singaporean and Thai staff. The data was collected fromsix participants, which were three Singaporeans and three Thais, by conducting a semi-structured interviewand implementing an active listening strategy. Data transcribing and scheme coding were used to analyzeand interpret the data, respectively. The reported intercultural communication patterns were using verbalcommunication, knowing the appropriateness of place and time, depersonalizing disagreement, and sharingspace between team members. The perspective of teamwork of Singaporean and Thai colleagues wasgroup work preference, however; they preferred to work on their own if they had confidence, andcompetency. The majority of participants agreed that reinforcement should be granted for the teamaccomplishment. They were aware of the importance of time. There were differences in how theparticipants managed their work. Singaporean employees preferred to do a variety of things at once, butThai employees believed things were scheduled to be done at particular times. Singaporean colleaguesproceeded their thought from general specific. In contrast, Thai employees proceeded their thought fromspecific to general. Lastly, both shared the same idea that decision making should be based on the facts,not personal likes or dislikes.
DOI: 10.25442/hku.14768004
title: Supporting data for "Adjuvant berberine for the management of antipsychotic-associated metabolic syndrome in patients with chronic schizophrenia: a literature review and a randomised controlled trial"

description: This is a dataset of the clinical trial "Berberine for antipsychotic-induced weight gain and metabolic syndrome: a randomised controlled trial". The demographic and clinical characteristics of 113 recruited subjects, as well as their study outcomes, are included in spreadsheets.
DOI: 10.25442/hku.14768004.v1
title: Supporting data for "Adjuvant berberine for the management of antipsychotic-associated metabolic syndrome in patients with chronic schizophrenia: a literature review and a randomised controlled trial"

description: This is a dataset of the clinical trial "Berberine for antipsychotic-induced weight gain and metabolic syndrome: a randomised controlled trial". The demographic and clinical characteristics of 113 recruited subjects, as well as their study outcomes, are included in spreadsheets.
DOI: 10.6084/m9.figshare.14783613
title: Supplementary Material for: Pseudoprogression with Neoadjuvant Immunotherapy for Cutaneous Melanoma

description: Immune checkpoint inhibitors (ICI) have drastically changed the landscape of metastatic melanoma management, thus significantly improving survival. Clinically, assessing treatment response may be challenging in a portion of cases due to a massive influx of immune cells into the tumor microenvironment, causing a transient increase in the target lesion size. This phenomenon, coined pseudoprogression, can occur in 5–10% of metastatic patients, and it is commonly followed by a tumor regression. Its incidence, however, may be underestimated, given its ephemeral nature and often being documented in visceral metastatic lesions, which are only assessed by imaging scans every 2–3 months. More recently, ICI has been studied in the neoadjuvant setting, yielding durable pathological responses in patients with cutaneous melanoma. Here, we report a case of a large retroauricular melanoma mass with regional lymph node involvement treated with ipilimumab and nivolumab combination therapy that developed pseudoprogression. Initially documented as an increase in size along with inflammatory features, followed by a dramatic clinical improvement. A complete regression was pathologically documented after 3 months and the patient remains disease-free for 14 months after treatment initiation. In conclusion, we document a pseudoprogression case during neoadjuvant ICI treatment and raise the question of whether the incidence of this phenomenon is higher when observed in superficial lesions, which can be assessed by routine physical exam.
DOI: 10.6084/m9.figshare.14783640
title: Supplementary Material for: Drug-Induced Liver Injury in a Patient with Nonsmall Cell Lung Cancer after the Self-Administration of Fenbendazole Based on Social Media Information

description: Fenbendazole is a benzimidazole anthelmintic agent, with a broad antiparasitic range in animals such as dogs and pigs. The agent is also reported to exert antitumor effects and inhibit microtubule-associated tubulin polymerization, but its safety and tolerability profile in humans remains unclear. An 80-year-old female patient with advanced nonsmall cell lung cancer (NSCLC) was started on pembrolizumab monotherapy. The patient experienced severe liver injury 9 months later. An interview with her and her family revealed that she had been taking fenbendazole for a month, solely based on social media reports suggesting its effectiveness against cancer. After discontinuation of the self-administration of fenbendazole, the patient’s liver dysfunction spontaneously resolved. The antitumor inhibitory effects of fenbendazole have been reported; however, she did not experience tumor shrinkage. This is the first case report of a patient with advanced NSCLC who self-administered the anthelmintic, fenbendazole. Twitter and Facebook are online social media platforms which have been constructively used to exchange information among cancer patients. However, sources of medical information on these platforms are often unproven, and it is difficult for nonmedical professionals to accurately select and filter complex medical information. Physicians should enquire patients about self-administration of orally ingested products, including dietary supplements, herbs, or bioactive compounds, in cases of unexpected adverse reactions.
DOI: 10.6084/m9.figshare.14783640.v1
title: Supplementary Material for: Drug-Induced Liver Injury in a Patient with Nonsmall Cell Lung Cancer after the Self-Administration of Fenbendazole Based on Social Media Information

description: Fenbendazole is a benzimidazole anthelmintic agent, with a broad antiparasitic range in animals such as dogs and pigs. The agent is also reported to exert antitumor effects and inhibit microtubule-associated tubulin polymerization, but its safety and tolerability profile in humans remains unclear. An 80-year-old female patient with advanced nonsmall cell lung cancer (NSCLC) was started on pembrolizumab monotherapy. The patient experienced severe liver injury 9 months later. An interview with her and her family revealed that she had been taking fenbendazole for a month, solely based on social media reports suggesting its effectiveness against cancer. After discontinuation of the self-administration of fenbendazole, the patient’s liver dysfunction spontaneously resolved. The antitumor inhibitory effects of fenbendazole have been reported; however, she did not experience tumor shrinkage. This is the first case report of a patient with advanced NSCLC who self-administered the anthelmintic, fenbendazole. Twitter and Facebook are online social media platforms which have been constructively used to exchange information among cancer patients. However, sources of medical information on these platforms are often unproven, and it is difficult for nonmedical professionals to accurately select and filter complex medical information. Physicians should enquire patients about self-administration of orally ingested products, including dietary supplements, herbs, or bioactive compounds, in cases of unexpected adverse reactions.
DOI: 10.14457/cu.the.1985.6
title: การออกแบบแผ่นพื้นสี่เหลี่ยมผืนผ้าซึ่งมีช่องเปิด และที่รองรับเป็นแนวเส้นโดยทฤษฎียีลด์ไลน์
DOI: 10.14457/cu.the.2010.2191
title: Optimization of chemical saccharification of sweet sorghum straw and bagasse for ethanol fermentation

description: Sweet sorghum straw and sugarcane bagasse are lignocellulosic materials that are promoted as an alternative feedstock for ethanol production because it is available and inexpensive. Due to its composition of cellulose and hemicellulose, that could be hydrolyzed into fermentable sugars. Conversion of these potential feedstocks requires a pretreatment step to alter the microscopic size and structure of the lignocellulose. This research was studied in order to find the optimum conditions on hydrolysis of sweet sorghum straw and sugarcane bagasse using dilute-acid or dilute-alkaline pretreatment. The biomass was mixed with dilute sulfuric acid (0-3%v/v) or dilute sodium hydroxide (0-4%w/v) with solid loading of 10% w/v and then pretreatment at hight temperatures (120-190°C) for 10-30 min of pretreated times. The maximum yield of glucose and xylose from sorghum straw was 0.234 g glucose/g dry substrate and 0.208 g xylose/g dry substrate, respectively, at the pretreatment condition : 120ºC, 3%H₂SO₄ for 10 min. In this case, a total of 50.04% of glucan and 76.41% of xylan were converted to glucose and xylose, respectively. In the case of bagasse, pretreatment at 170°C, 3%H₂SO₄ for 20 min gave the maximum yield of glucose of 0.367 g glucose/g dry substrate and a total of 78.52% of glucan was converted to glucose. Pretreatment at 120°C, 3%H₂SO₄ for 20 min, gave the maximum yield of xylose of 0.226 g xylose/g dry substrate and a total of 83.05% of xylan was converted to xylose. After chemical pretreatment, the hydrolyzates of sorghum straw and bagasse were detoxified and concentrated by overliming and evaporation method, respectively. The hydrolyzates containing 20 g/l and 50 g/l of reducing sugars were fermented with separate hydrolysis and fermentation (SHF) process using Saccharomyces cerevisiae and Pichia stipitis at 30ºC, pH 5.5 and agitation rate of 150 rpm. The fermentation of sorghum straw hydrolyzate, containing 20 g/l of reducing sugars by P. stipitis gave the highest ethanol concentration of 10.17 g/l at 46 hr. Whereas S. cerevisiae gave the ethanol concentration of 6.38 g/l at 12 hr. In case of fermentation bagasse hydrolyzate by P. stipitis and S. cerevisiae gave ethanol concentration of 3.73 g/l at 32 hr and 1.78 g/l at 9 hr, respectively.
DOI: 10.14457/cu.the.1985.7
title: การศึกษาการปรับปรุงคุณภาพดินที่บริเวณงานก่อสร้างท่าอากาศยาน กรุงเทพแห่งที่สอง (หนองงูเห่า)
DOI: 10.14457/cu.the.2010.2192
title: Different quality of HIV-1 GAG P24 specific T cell response between viraemic controllers and progressors

description: Immune correlates of protection against HIV infection are crucial for a successful HIV-1 vaccine development. Study in a unique group of infected individuals who are able to control HIV naturally (HIV controllers; HIV load less than 2,000 copies/ml without antiretroviral therapy) have provided us a chance to investigate the role of host immune responses in HIV protection. In this study, the functional quality of HIV-1 Gag p24-specific-CD8⁺ T cell responses on HIV-1 control were assessed and compared between the groups of clinically distinct HIV-1 infected individuals, viraemic controllers (VC, pVL &lt; 2,000 copies/ml) and typical progressors (TP, pVL &gt; 2,000 copies/ml) to determine their impacts on natural HIV-1 clinical outcome. The functional quality of specific-CD8⁺ T cell responses was defined as the number of function simultaneously performed (from single to full 5 functions of IL-2, TNF-α, IFN-γ, MIP1-β and CD107a expression). In agreement with previous study, HIV-1 Gag p24-specific-CD8⁺ T cell responses of VC were composed of higher functional quality CD8⁺ T cells than that of TP (p &lt; 0.05). This high functional quality of HIV-1 Gag p24-specific-CD8⁺ T cell responses observed in VC were independent of age, duration of HIV-1 infection or even presence of protective HLA-I alleles (HLA-B*27, -B*57 and –B*58) and were observed at both a whole p24 protein specific and a single epitope specific level. Moreover, the absolute number of high functional quality HIV-1 Gag p24-specific-CD8⁺ T cells was significantly in a negative correlation with pVL (r = -0.6984, p = 0.0006) and also in a positive correlation with CD4⁺ T cell count (r = 0.5648, p = 0.0095), hence clearly illustrated their roles in determining HIV-1 clinical outcome. In conclusion, this study indicated that possession of an adequate numbers of high functional quality HIV-1 p24-specific-CD8⁺ T cells is important in order to become a natural HIV controller and provided a solid evidence supporting their roles as an immune correlate of HIV-1 protection. The information obtained from this study will pave the way toward a successful HIV-1 T-cell based vaccine in the near future.
DOI: 10.14457/cu.the.2010.2193
title: Mechanisms of carbapenem resistance in acinetobacter baumannii clinical isolates

description: Acinetobacter baumannii is an important cause of nosocomial infection. Carbapenems are the first line drug for treatment of multidrug-resistant A. baumannii infections. Currently, carbapenem-resistant A. baumannii isolates have been increasingly reported worldwide. In this study, the prevalence and the mechanisms of carbapenem resistance in A. baumannii including the production of carbapenemases, the presence of efflux pump and the loss or decrease of outer membrane protein were investigated. A total of 453 A. baumannii isolated from patients at King Chulalongkorn Memorial Hospital between 2008-2010 were studied. The prevalence of imipenem and meropenem resistance were both 88.7%. Carbapenemase activity was found in all carbapenem-resistant A. baumannii isolates but metallo-β-lactamase enzymes were not detected in any isolates. Screening for the presence of carbapenemase genes by multiplex PCR revealed that blaOXA-51-like was detected in all isolates. Of the 402 carbapenem-resistant A. baumannii isolates, 99.8% carried blaOXA-51-like with blaOXA-23-like, 0.2% haboured blaOXA-51-like with blaOXA-24-like and 4% had blaOXA-51-like with blaOXA-23-like and blaOXA-58-like. The metallo-β-lactamase genes were not found in any isolate. The ISAba1 was found in the upstream region of blaOXA-23 in all 38 representative carbapenem-resistant A. baumannii isolates and ISAba3 was found upstream region of blaOXA-58 in all 4 representative isolates. Sequencing analysis of entire blaOXA-like showed that all 15 representative blaOXA-23-like genes were blaOXA-23 and all 4 blaOXA-58-like genes were blaOXA-58. Twelve representative blaOXA-51-like genes were blaOXA-65 (4 isolates), blaOXA-66 (7 isolates) and blaOXA-69 (1 isolate). Five representative ISAba1 upstream region blaOXA-23-like and all 4 ISAba3 upstream region blaOXA-58-like genes had -35 and -10 sequences. The presence of efflux pump mechanism by using carbonyl cyanide m-chlorophenylhydrazone (CCCP), the efflux pump inhibitor, was determined in all 453 isolates. No carbapenem-resistant A. baumannii isolates had this mechanism. Twenty-three A. baumannii isolates were determined for the loss or decrease of outer membrane protein. Five carbapenem-resistant isolates had decreased 43 kDa outer membrane protein. This study showed high rate of carbapenem-resistant A. baumannii isolates in Thailand and demonstrated that carbapenem resistance was attributed to the production of carbapenemases and the reduction of outer membrane protein. The main mechanism of resistance was the production of OXA-23-like carbapenemases.