cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.14457/cu.the.2011.1722
title: The relationship among DNA methylation, endogenous DNA double strand breaks and genomic instability

description: Inhibition of DNA-PKcs-mediated non-homologous end joining (NHEJs) under drug- induced histone acetylation reduces cell survival. However the mechanism is not well understood. Recently, we developed a new PCR-based technique to measure the amounts and types of epigenetic modification of endogenous DNA double strand breaks (EDSBs). We found that EDSBs in cells at G0 stage, known as replication-independent EDSBs (RIND-EDSBs) exist in two classes, namely, those present at a given level in all cell types under normal physiological conditions (named NRIND-EDSBs), which are hypermethylated, retained in facultative heterochromatin, devoid of γ-H2AX phosphorylation, and are repaired by a slow but more precise ATM-mediated NHEJs; and those (known as PRIND-EDSBs) that are hypomethylated and bound by γ-H2AX are only detected when DSB repair is inhibited. As NRIND-EDSBs are found in all cell types, we propose that they may possess normal physiological function. On the other hand, cells recognize PRIND-EDSBs as equivalent to radiation-induced DSBs and may be pathogenic. NRIND-EDSBs were reduced when chromatin became hyperacetylated by treatment with 100 ng/ml trichostatin A (TSA) (histone deacetylase inhibitor), but were increased when cells were treated with a combination of 100 ng/ml TSA, 2.5 mM vanillin (DNA-PKcs inhibitor) and 5 mM caffeine (ATM inhibitor). Therefore, we hypothesize that NRIND-EDSBs prevent PRIND-EDSB production, and that reduction of NRIND-EDSBs should increase PRIND-EDSBs, leading to cell death when repair of EDSBs are inhibited. We observed a reduction in NRIND-EDSBs under three situations: DNA hypomethylation, histone hyperacetylation and down regulation of high-mobility group protein B1 (HMGB1). We also found variations in NRIND-EDSB levels under normal culture conditions. When TSA-treated cells or those containing reduced levels of HMGB1 were exposed to vanillin, there was an increase in PRIND-EDSBs after 2 hours. Consequently, lower survivals were observed in both types of test cells. There is also a direct correlation between NRIND-EDSB level and resistance to vanillin treatment. In summary, NRIND-EDSBs are maintained in normal cells at a given level by DNA methylation, histone acetylation and an appropriate amount of HMGB1. Reduction in NRIND-EDSBs results in an increase in PRIND-EDSBs, thereby causing cell death when cells are treated with inhibitor of DSB repair (viz. vanillin). We postulate that in the absence of DNA repair inhibitors, PRIND-EDSBs should lead to DSB repair errors. Thus, a reduction of NRIND-EDSBs as a result of global hypomethylation, histone hyperacetylation or reduction of HMGB1 may underlie genomic instability.
DOI: 10.18112/openneuro.ds002237.v1.1.0
title: Briefly cueing memories leads to suppression of their neural representations
DOI: 10.14457/cu.the.2011.1723
title: Comparison inamount of extruded irrigant during final flush using Conventional method and endoactivator® in root canal system with different apical preparation sizes

description: The purpose of this study was to investigate the amount of sodium hypochlorite extrusion from root canal when using the EndoActivator® with different apical preparation sizes compared to the conventional irrigation method. 100 extracted human maxillary anterior teeth with mature apices were instrumented and divided into 3 groups (30 teeth/group) based on the 3 different apical sizes: #35, #50, #80. Each tooth was fixed in agarose gel and irrigated with both needle (NG) and EndoActivator© (EA) techniques. The data of apical extrusion is collected in 2 parts, which are color changed detection and weight difference of model. Differences in apical extrusion volumes were analyzed by Kruskal-Wallis test (p &lt; 0.05). In positive control group and models with increasing weights, the color change of agarose gel was observed from colorless to blue color. On the other hand, there was no color change in negative control group and in teeth with apical preparation of size #35 that corresponded to the result of no weight change. When root canal was prepared to apical size #35, weight change was not observed in both NG and EA groups. However, the extrusion volume was increasing when apical preparation size increased regardless of irrigation technique used. There were significant difference in extrusion volume among root canals with apical size #50 and 80 in NG and EA groups However, there was no significant difference between root canal with apical size #50 in NG group and apical size #80 in EA group (p&gt;0.05). In conclusion, the apical extrusion depended on apical preparation size and irrigating systems. When increased in apical preparation size, amount of NaOCl extrusion was greater. There was few amount of apical extrusion when using EndoActivator®. Although, apical extrusion volume in EndoActivator® using was greater when increased in apical preparation size, the extrusion was less in EndoActivator® system when compared with needle and syringe irrigation.
DOI: 10.14457/cu.the.2011.1724
title: Innovative marketing tool by applying opinion mining on the micro-blog

description: Traditional marketing research approaches may not adequate for today business competitions because they require a large amount of time and resources. As a supportive solution, the researcher proposes a system called the Micro-blog Sentiment Analysis System (MSAS), based on the opinion mining concept to automatically analyze consumer opinions from the micro-blog. The MSAS consists of five main modules to (1) collect micro-blog posts, (2) filter opinion posts from entire posts, (3) detect polarity in each post, (4) categorize product features, and (5) summarize and visualize the overall results. The research process composed of both qualitative and quantitative approaches; starting this study from the focus group discussion to scope the business requirements. Then, five in-depth interviews were conducted to find out the direction of the software development; researchers had chosen some important functions to implement the software prototype by using the smartphone as the case study and collected posts from Twitter as a proper representative of the micro-blog service. Lastly, the research process did focus group discussion to verify the result of the software prototype by adopting Technology Acceptance Model in this session. The final result of both Perceived Usefulness and Perceived Ease of use is “agree” while the attitude toward using this software is “strongly agree”. The outcome of this study is a prototype of innovative marketing tool that applying the opinion mining concept on the micro-blog with Johari Window to answer the consumer insight question. It will be a guideline for people in the software industry to cross the disciplinary to the marketing research field in the future.
DOI: 10.14457/cu.the.2011.1725
title: Effects of curcumin on dna damage, cell proliferation, and incidence of gastric cancer induced by high salt and n-methyl-n-nitrosourea in rats

description: Gastric cancer can generate in any part of the stomach. Because of poorly detected, gastric cancer causes the public health problem worldwide. Curcumin has anti-oxidant and chemopreventive properties. To determine whether curcumin could attenuate the gastric cancer incidence and the key proteins involved in carcinogenesis induced by saturated salt (s-NaCl) and N-methyl-N-nitrosourea (MNU) in rats. Male Wistar rats were divided into 6 groups: 1 control (CO), 2 control supplemented with 200 mg/kg curcumin (CC), 3 MNU+s-NaCl, 4 MNU+s-NaCl supplemented with 200 mg/kg curcumin daily for the first 3 weeks (MNU+s-NaCl+C3W), 5 MNU+s-NaCl rats supplemented with curcumin after induction (MNU+s-NaCl+C17W), and 6 MNU+s-NaCl supplemented with curcumin for 20 weeks (MNU+s-NaCl+C20W). To induce stomach cancer, rats except for group 1 and 2 were orally treated with 100 mg/kg MNU on day 0 and 14, and s-NaCl twice-a-week for the first 3 weeks. The experiment was finished and rats were sacrificed at the end of 20 weeks. The stomachs were removed for histological examination. The expressions of 8-hydroxy-2’-deoxyguanosine (8-OHdG) and cyclin D1 were investigated by immunohistochemistry. Western blot technique was used to examine phosphorylated inhibitor kappaB alpha (ӀҡB∝), and Bcl-2 expressions Cancers were found in the forestomach of all rats in group 3 and 5. Curcumin supplementations in group 4 and 6 showed 40% and 50% reduction of cancer incidence, respectively. Expressions of 8-OHdG, cyclin D1, and Bcl-2 significantly increased in group 3 compared with group 1. The phospho-ӀҡB∝ expression had a tendency to increase in group 3 compared with group 1. Immunoreactive cells of 8-OHdG in group 5 and 6 significantly decreased when compared with group 3 (46.43% ± 4.42 and 46.38% ± 3.14 vs. 53.06% ± 5.96; p = 0.012 and p = 0.011, respectively). The relative intensity of phospho-ӀҡB∝ in group 4 tended to reduce when compared with group 3. In conclusion, MNU and s-NaCl administrations lead to forestomach cancer and increase of 8-OHdG, cyclin D1, and Bcl-2 expressions in rats. Early supplementation of curcumin could attenuate the incidence of cancer at 50% with the significant reduction of 8-OHdG.
DOI: 10.14457/cu.the.2011.1726
title: Graft copolymerization of natural rubber with fluorine containing monomer

description: The blending of two elastomers with different polarities and vulcanization systems such as natural rubber (NR) and fluoroelastomers (FKM) leads to the incompatibility and phase separation resulting in poor mechanical properties of finishing rubber products. The chemical modification via graft copolymerization is the technique to promote the compatibility of the blends with dissimilar properties. In this study, the fluorine containing monomer used for grafting onto NR backbone was 2,2,2-trifluoroethyl methacrylate (TFEM) via free radical graft copolymerization carried out by both of melt-mixing and solution-grafting processes initiated by benzoyl peroxide (BPO). The grafting properties were investigated as functions of grafting process, initiator and monomer concentration, reaction temperature and time. Under the optimum conditions, it was found that the obtained graft natural rubber (GNR) contained the maximum level of grafting efficiency as 1.34 % with grafted poly (2,2,2-trifluoroethyl methacrylate) (PTFEM) content as 0.26 phr. The structure of GNR was analyzed by using attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR) and nuclear magnetic resonance spectroscopy (NMR). The glass transition temperature of samples was characterized by differential scanning calorimetry (DSC). The GNR was then applied as the compatibilizer for NR/FKM vulcanizates. The amount of GNR at 15 phr yielded the maximum tensile strength of the vulcanizate as 9.93 MPa, which was 5.31 times higher than that of incompatibilized one (1.87 MPa) due to the higher homogeneity of constituent phases.
DOI: 10.14457/cu.the.2011.1727
title: Heterogeneous base catalysts from natural dolomite for transesterification of vegetable oil

description: The present thesis investigated preparation of heterogeneous base catalysts from natural dolomite for transesterification of plam oil with methanol. The catalysts were prepared by dissolution-precipitation method. Typically, the calcined dolomite was mixed with aluminium oxide as a binder, sodium aluminate and hydroxyethyl cellulose (HEC) as a plasticizer in a solution of nitric acid with pH of 1. The resulting catalyst paste was formulated as extrudates (5 mm) by using a manual extruder. The extrudates attained were finally calcined at 500-800 °C. Effects of the preparation conditions, including pH of nitric acid solution, amount of deionized water, amount of HEC, drying temperature, calcination temperature and addition of sodium aluminate on the physicochemical and the catalytic properties were investigated. The properties of the catalysts were studied by using X-ray fluorescence spectroscopy (XRF), X-ray diffraction (XRD), scanning electron microscopy (SEM), thermogravimetric/ differential thermal analysis (TG/DTA), N₂ adsorption-desorption measurement, temperature-programammed desorption of CO₂ (CO₂-TPD) and CO₂-pluse chemisorption analysis. The suitable conditions for the catalyst preparation are the mass ratio of dolomite/alumina/sodium aluminate = 70:20:10, the amount of HEC is 3 wt.% relative to the solid mass, the pH of nitric acid solution of 1, the amount of deionized water of 1.5 times of the total solid, the calcination temperature of 800 °C. The catalyst extrudates attained can catalyze the transesterification of palm oil with methanol in a fixed-bed reactor giving a high fatty acid methyl ester yield (54.3%) with retention of the extrudate shape.
DOI: 10.14457/cu.the.2011.1728
title: Quality and drying characteristics of dried papaya pretreated with binary and ternary osmotic solutions

description: In this study, the effect of using binary (sucrose - water) and ternary solution (sucrose - salt - water) on mass transfer, drying characteristics, and final quality of dried papaya was investigated. Papaya pieces were immersed in three different sucrose solutions (50, 55, and 60 oBrix) with three different levels of sodium chloride (0, 3, and 5 % w/v) for five hours. Every hour, water loss, solid gain, and weight reduction of papaya in each treatment were calculated. It was found that the addition of sodium chloride led to a significant increase in both water loss and solid gain. The osmosed papaya chunks were then dried in a hot air dryer at 60 ℃. Results obtained from drying curve showed that the samples soaked in ternary solution had a higher drying rate, leading to shorter drying time. In general, the modified Henderson & Pabis appeared to be the best model to predict the drying curve of osmosed papaya from all treatments. For the final product quality, the use of ternary solution has an effect on water activity, water mobility, color, and texture properties. From the microstructure analysis, the disruption of the shape and deformation of the cell structure of papaya was likely to be seen in the sample pretreated with ternary solution compared to the sample pretreated with binary solution. Based on sensory analysis, the use of ternary solution led to better quality in color and appearance, with the overall acceptance can be considered as acceptable.
DOI: 10.14457/cu.the.2011.1729
title: Application of wide area monitoring system for securing voltage stability

description: Wide Area Monitoring System (WAMS) using Phasor Measurement Unit (PMU) as the input devices is an advanced tool, which can help system operators monitor a power system condition, including voltage stability performance, in real time. The objectives of this thesis have two folds which are to determine the minimum number and location of the PMU to be installed given power network topology, and to propose the application of WAMS for monitoring voltage stability performance. The solution method of determining the minimum number and location of the PMU has been selected by comparing the effectiveness of the three methods proposed in the literatures, which are the Graph Theoretic Procedure, the Recursive N Method and the Generalized Integer Linear Programming. In this thesis, the Generalized Integer Linear Programming is chosen in regard to the observability performance. Then, the implementation of WAMS consisting of selecting suitable voltage stability indexes (VSI), employing linearly formulated state estimation technique, and designing graphic user interface (GUI) has been developed. The Synchrophasor-Based Real-Time Voltage Stability Index (SBRT VSI) and the PQ Voltage Stability Index (PQVSI), which suit well for on-line application, are used to identify the weak bus and the weak line rankings, respectively. The effectiveness of the developed WAMS has been successfully demonstrated using the simulated data of the IEEE 14-bus test system under four scenarios combining the effects of continued load increases at various load buses simultaneously, and short circuit faults. All the computed, on-line performance indexes including the critical point on the PV curve shown in the GUI have been verified against the actual values obtained later from the dynamic simulation of the system for the corresponding conditions.
DOI: 10.5281/zenodo.3518238
title: A Validated Set of Smells in Model-View-Controller Architectures: ICSME 2016 appendix

description: Appendix of our ICSME 2016 paper.
DOI: 10.5281/zenodo.3518239
title: A Validated Set of Smells in Model-View-Controller Architectures: ICSME 2016 appendix

description: Appendix of our ICSME 2016 paper.
DOI: 10.14457/cu.the.2011.1730
title: Moving toward multicultural society? : South Korea’s migration trends and policies with the focus on foreign labor

description: The purpose of this thesis is to study the migration trends and immigration policies of South Korea with the focus on foreign labor and to discuss the obstacles and problems that might occur as a result of the increase of foreign population. The study is done by using the secondary academic data collected through various sources including special reports, findings from previous studies, books, periodicals, journals and internet by focusing on the First Basic Plan for Immigration Policy 2008-2012, the related policies, and the information related to the immigration in South Korea. Findings of this study reveal the main purpose of South Korea’s immigration policies that aim to achieve multicultural society and its high demand for foreign labor in order to help the country accelerating economic development and enhancing the national competitiveness. However, widely recognized as a homogeneous nation with a strong consciousness of ethnic nationalism, the government’s determination to achieve multicultural society might be obstructed. Moreover, the aim to attract more foreign talents and manpower might result in social frictions and social problems caused by ethnic and cultural diversities and miscommunication between the Korean nationals and the newcomers. Therefore, in addition to the encouragement and support of the language and cultural study for foreigners to help them adjust themselves more comfortably to the Korean society, the government has tried to create a better understanding among the natives through public education about the change that will occur in order to strengthen the social cohesion where the Koreans and foreigners could live together happily. Thus, if South Korea could eliminate the conflicts and discrimination that caused by the difference in ethnicity and cultures, more foreigners with desirable potentials would immigrate into South Korea and possibly help South Korea push ahead the economic development without causing social frictions. However, to achieve the goal of being a multicultural society might be a time-consuming process.
DOI: 10.14457/cu.the.2011.1731
title: Electricity generation from cassava wastewater by a single chamber microbial fuel cell

description: This study examined the effects of the organic loading rate (OLR), pH and the temperature in cassava wastewater treatment and the power generated by a single microbial fuel cell. The study was divided into two parts under temperature of 45 ℃ and 30 ℃. The first part was examined the effect of OLR of 0.56, 1.44, 2.79, 4.14 to 6.25 kg-COD/m³-d at pH 7.0 to remove COD and generate electricity. The second part was examined the effect of pH at 5.0, 5.5, 6.0, 6.5, 7.5, 8.0, 8.5 and 9.0 on OLR of 0.56 kg-COD/m³-d to remove COD and generate electricity. When controlled pH 7.0, the efficiency of COD removal was achieved at maximum from the OLR of 0.56 kg-COD/m³-d at both temperatures. The efficiency of COD removal was 91.44 ± 0.72% and 90.72± 0.87% at 30 ℃ and 45 ๐C respectively. The maximum of power density was obtained from OLR of 6.25 kg-COD/m³-d, which the value was 28.68 W/m3 at 30 ๐C and 27.85 W/m3 at 45 ℃. The maximum of coulombic efficiency was obtained from the OLR of 0.56 kg-COD/m³-d which was 30.2% at 30 ℃ and 28.5% at 45 ℃. The temperature affected on the electron transferring from anode to cathode. At the lower temperature, electron was able to transfer from anode to cathode more effectively than at higher temperature. High temperature caused high electrical resistant, so the power output decreased when temperature increased. At OLR of 0.56 kg-COD/m³-d, the maximum efficiency of COD removal was achieved at a pH of 7.5 at both temperatures. The efficiency of COD removal was as 96.77 ± 0.93% and 95.93± 1.44% at 30 ℃ and 45 ℃ respectively. The maximum of power density obtained from pH 8.5 which the values were 30.30 W/m³ at 30 ℃ and 26.06 W/m³ at 45 ℃. The maximum of coulombic efficiency was obtained from pH 8.5 which was 52.9% at 30 ℃ and 50.6% at 45 ℃. The microbial communities in the anode of a single chamber microbial fuel cell under 30 ℃ could be divided into four groups as Gammaproteobacteria, Betaprotobacteria, Bacteroidetes and Firmicutes. While under 45 ℃ operation, the microbial communities could be divided into three groups as Gammaproteobacteria, Betaprotobacteria and Firmicutes. The microbial communities included several fermentative bacteria, exocellular electron-transfer, methane oxidizers, sulfate-reducing bacteria and groups of facultative bacteria.
DOI: 10.14457/cu.the.2011.1732
title: Synthesis and characterization of ziegler-natta catalyst with various support systems

description: Heterogeneous Ziegler-Natta catalysts for ethylene polymerization were prepared with various support systems, MgCl₂, MgCl₂/SiO₂ and Mg(OEt)₂. The objectives are to improve the morphology of catalyst and to decrease the fragmentation of catalyst’s particle during catalyst preparation. For MgCl₂/TiCl4 and MgCl₂/SiO₂/TiCl4, the MgCl₂ support was prepared via recrystallization of anhydrous MgCl₂ in ethanol-hydrocarbon solution. The bi-support (MgCl₂/SiO₂) was prepared by impregnation of MgCl₂•nEtOH adduct on SiO₂ surface in heptane media. After that, reaction with TiCl₄ was performed to obtain the catalyst. In the case of Mg(OEt)₂/TiCl₄, the MgCl₂ support was prepared by chemical reaction between Mg(OEt)₂ and TiCl4. The result shows that using of SiO₂ in bi-support system could improve morphology of MgCl₂-based catalyst with spherical shape. Moreover, SiO₂ could reduce the effect of ethanol, which is the key parameter to control the morphology and activity of MgCl₂/TiCl₄ catalyst. Hydrogen response in ethylene polymerization and stability of catalyst were also studied. For Mg(OEt)₂/TiCl₄ system, the results show that the morphology of catalyst replicated the morphology of Mg(OEt)₂ precursor and highly catalytic activity was achieved. Additional, the effect of internal electron donor and catalyst’s preparation conditions and catalyst’s performance in ethylene and propylene polymerization were also studied.
DOI: 10.14457/cu.the.2011.1733
title: Preparation of sewage sludge-based adsorbent for ammonia gas removal

description: Adsorbents derived from waste sewage sludge for ammonia gas removal were prepared by carbonization under air atmosphere and modification with H₃PO₄, H₂PO₄ or ZnCl₂. The physical properties of obtained adsorbents were characterized by thermogravimetric analysis, scanning electron microscopy and surface area analysis and the chemical properties by titration method and flame atomic absorption spectroscopy. The ammonia adsorption study was carried out in a fixed bed reactor. The surface area and the fixed carbon content of adsorbents increased after carbonization. The suitable condition for adsorbent preparation was the carbonization at 500℃ and modification with 3M of H₃PO₄, H₂SO₄ and ZnCl₂, the ammonia adsorption efficiency of the adsorbents was found to be 81.95, 90.59, 109.78 mg/g, respectively. The initial ammonia concentration and column size strongly affected the adsorption efficiency. The mechanism of ammonia adsorption on acid and ZnCl2 modified adsorbents occurred via Brønsted-Lowry acid-base reaction and the formation of ZnCl₂•NH₄Cl on surface.