cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.5281/zenodo.7040282
title: Protein aggregation and calcium dysregulation are the earliest hallmarks of familial Parkinson's disease in human midbrain dopaminergic neurons

description: Mutations in the <em>SNCA</em> gene cause autosomal dominant Parkinson’s disease (PD), with loss of dopaminergic neurons in the substantia nigra, and aggregation of α-synuclein. The sequence of molecular events that proceed from an <em>SNCA</em> mutation during development, to end stage pathology is unknown. Utilising human induced pluripotent stem cells (hiPSCs), we resolved the temporal sequence of SNCA induced pathophysiological events in order to discover early, and likely causative, events. Our small molecule-based protocol generates highly enriched midbrain dopaminergic (mDA) neurons: molecular identity was confirmed using single-cell RNA sequencing and proteomics, and functional identity through dopamine synthesis, and measures of electrophysiological activity. At the earliest stage of differentiation, prior to maturation to mDA neurons, we demonstrate the initial formation of small β-sheet rich oligomeric aggregates, in <em>SNCA</em>-mutant cultures. Aggregation persists and progresses, ultimately resulting in the accumulation of phosphorylated aggregates. Impaired intracellular calcium signalling, increased basal calcium, and impairments in mitochondrial calcium handling occurred early at day 34-41 post differentiation. Once midbrain identity fully developed, at day 48-62 post differentiation, <em>SNCA</em>-mutant neurons exhibited mitochondrial dysfunction, oxidative stress, lysosomal swelling and increased autophagy. Ultimately these multiple cellular stresses lead to abnormal excitability, altered neuronal activity, and cell death. Our differentiation paradigm generates an efficient model for studying disease mechanisms in PD, and highlights that protein misfolding to generate intraneuronal oligomers is one of the earliest critical events driving disease in human neurons, rather than a late-stage hallmark of the disease.
DOI: 10.5281/zenodo.7138359
title: Protein aggregation and calcium dysregulation are the earliest hallmarks of familial Parkinson's disease in human midbrain dopaminergic neurons

description: Mutations in the <em>SNCA</em> gene cause autosomal dominant Parkinson’s disease (PD), with loss of dopaminergic neurons in the substantia nigra, and aggregation of α-synuclein. The sequence of molecular events that proceed from an <em>SNCA</em> mutation during development, to end stage pathology is unknown. Utilising human induced pluripotent stem cells (hiPSCs), we resolved the temporal sequence of SNCA induced pathophysiological events in order to discover early, and likely causative, events. Our small molecule-based protocol generates highly enriched midbrain dopaminergic (mDA) neurons: molecular identity was confirmed using single-cell RNA sequencing and proteomics, and functional identity through dopamine synthesis, and measures of electrophysiological activity. At the earliest stage of differentiation, prior to maturation to mDA neurons, we demonstrate the initial formation of small β-sheet rich oligomeric aggregates, in <em>SNCA</em>-mutant cultures. Aggregation persists and progresses, ultimately resulting in the accumulation of phosphorylated aggregates. Impaired intracellular calcium signalling, increased basal calcium, and impairments in mitochondrial calcium handling occurred early at day 34-41 post differentiation. Once midbrain identity fully developed, at day 48-62 post differentiation, <em>SNCA</em>-mutant neurons exhibited mitochondrial dysfunction, oxidative stress, lysosomal swelling and increased autophagy. Ultimately these multiple cellular stresses lead to abnormal excitability, altered neuronal activity, and cell death. Our differentiation paradigm generates an efficient model for studying disease mechanisms in PD, and highlights that protein misfolding to generate intraneuronal oligomers is one of the earliest critical events driving disease in human neurons, rather than a late-stage hallmark of the disease.
DOI: 10.25430/researchdata.cab.unipd.it.00000717
title: Assessing the optimal setup for continuous water level monitoring in ephemeral streams: experimental evidence

description: Dataset about stage length and water level estimation experiments, as analyzed in the manuscript "Assessing the optimal setup for continuous water level monitoring in ephemeral streams: experimental evidence"
DOI: 10.6084/m9.figshare.21258573
title: Murphy et al 2022 data files

description: Data files from "A tool for monitoring cell type specific focused ultrasound neuromodulation and control of chronic epilepsy" Murphy et al 2022 <br>
DOI: 10.5281/zenodo.6505230
title: Statistics of temporal variations in the auroral electrojets over Fennoscandia- Dataset

description: This is the data that is the result of the methodology described in the associated paper and is required to produce the figures in said paper.
DOI: 10.5281/zenodo.6505229
title: Statistics of temporal variations in the auroral electrojets over Fennoscandia- Dataset

description: This is the data that is the result of the methodology described in the associated paper and is required to produce the figures in said paper.
DOI: 10.17862/cranfield.rd.19199765.v1
title: Data supporting: 'Modelling and optimising hybrid process of wire arc additive manufacturing and high-pressure rolling'

description: Figure 7 Predicted distortion of the WAAM component after removal of clamps.<br> <br> Figure 8 Longitudinal RS distributions along the vertical path in the symmetry plane for the long mechanical models after removal of clamps, as compared to experimental measurements [4]. The flat roller (a) and slotted roller (b) were used in the rolling simulations, and the long model was based on the steady-state solution mapped from the reduced-length WAAM + IL rolling model.<br> <br> Figure 10 Concurrent evolution of temperature and longitudinal stress (a), as well as the longitudinal PS (b), in the layer 6 during WAAM deposition of layers 6-8 in conjunction with IL rolling using the flat roller. The data were collected at the top of layer 6 in the inspection plane and the rolling phases are highlighted in the yellow shaded areas.<br> <br> Figure 11 Concurrent evolution of temperature and longitudinal stress (a), as well as longitudinal PS (b), in the layer 6 during WAAM deposition of layers 9-11 in conjunction with IL rolling using the flat roller. The data were collected at the top of layer 6 in the inspection plane and the rolling phases are highlighted in the yellow shaded areas.<br> <br> Figure 12 Concurrent evolution of temperature and longitudinal stress (a), as well as longitudinal PS (b), in the layer 6 during WAAM deposition of layers 12-14 in conjunction with IL rolling using the flat roller. The data were collected at the top of layer 6 in the inspection plane and the rolling phases are highlighted in the yellow shaded areas.<br> <br> Figure 13 Concurrent evolution of the longitudinal PS and stress in the layer 9 during WAAM deposition of layers 9-16 in conjunction with IL rolling using the slotted roller. The data were collected at the top of layer 9 in the inspection plane (the slotted roller started rolling on layer 6) and the rolling phases are highlighted in the yellow shaded areas.<br> <br> Figure 18 Evolution of longitudinal PS in the layer 6 during WAAM deposition and stacked 4L rolling with flat roller. The rolling phases are highlighted in the yellow shaded areas.<br>
DOI: 10.5281/zenodo.7138915
title: Supplementary Material

description: Supplementary Material
DOI: 10.5281/zenodo.7138914
title: Supplementary Material

description: Supplementary Material
DOI: 10.6084/m9.figshare.16529477
title: Calibration and initial validation of a low-cost computer-based screening audiometer coupled to consumer insert phone-earmuff combination for boothless audiometry

description: To undertake calibration and preliminary validation of a custom-designed computer-based screening audiometer connected to consumer insert phone-earmuff combination for adult pure tone audiometry. Part 1 involved electroacoustic measurement and biological calibration of a laptop-earphone pair used for the computer-based audiometry (CBA). Part 2 compared CBA thresholds obtained without a sound booth with those measured using the gold-standard clinical audiometry. 17 young normal-hearing volunteers (Part 1) and 43 normal and hearing loss subjects (Part 2) recruited from an audiology clinic via convenience sampling. The transducer-device combination produced outputs suitable for measuring thresholds down to 0 dB HL. Threshold pairs obtained from the CBA and clinical audiometry were highly correlated (Spearman’s correlation coefficient, <i>ρ</i> = 0.92, <i>p</i> &lt; 0.0001) and had a good degree of agreement (mean difference of −1.06 ± 7.63 dB). Also, the CBA showed about 90% sensitivity and 80% specificity for detecting hearing loss based on low (0.5, 1, 2 kHz) and high frequency (4, 8 kHz) pure tone averages of &gt;25 dB HL. The use of a computer-based audiometer application with consumer insert phone-earmuff combination can offer a cost-effective solution for boothless screening audiometry.
DOI: 10.6084/m9.figshare.16529477.v1
title: Calibration and initial validation of a low-cost computer-based screening audiometer coupled to consumer insert phone-earmuff combination for boothless audiometry

description: To undertake calibration and preliminary validation of a custom-designed computer-based screening audiometer connected to consumer insert phone-earmuff combination for adult pure tone audiometry. Part 1 involved electroacoustic measurement and biological calibration of a laptop-earphone pair used for the computer-based audiometry (CBA). Part 2 compared CBA thresholds obtained without a sound booth with those measured using the gold-standard clinical audiometry. 17 young normal-hearing volunteers (Part 1) and 43 normal and hearing loss subjects (Part 2) recruited from an audiology clinic via convenience sampling. The transducer-device combination produced outputs suitable for measuring thresholds down to 0 dB HL. Threshold pairs obtained from the CBA and clinical audiometry were highly correlated (Spearman’s correlation coefficient, <i>ρ</i> = 0.92, <i>p</i> &lt; 0.0001) and had a good degree of agreement (mean difference of −1.06 ± 7.63 dB). Also, the CBA showed about 90% sensitivity and 80% specificity for detecting hearing loss based on low (0.5, 1, 2 kHz) and high frequency (4, 8 kHz) pure tone averages of &gt;25 dB HL. The use of a computer-based audiometer application with consumer insert phone-earmuff combination can offer a cost-effective solution for boothless screening audiometry.
DOI: 10.6084/m9.figshare.21259335
title: data.xlsx

description: <br> The study was registered in and approved from the Medical Ethics Committee in the University of Kufa, college of medicine with reference: (MEC_13). The study protocol was registered in ClincialTrials.gov (identifier: <strong>NCT05398874</strong><strong>)</strong>. Participants were asked to sign a printed informed consent that explained the aim of study. This was a randomized double blinded clinical trial conducted in a private orthopaedic clinic in Al-Najaf Government in Iraq from November 1st 2021 to June 1st 2022. The doctor of clinic defined the patients that can be enrolled in the study and informed them about aim of study and take oral and written consent from them. Then the researcher randomized patients into two groups using simple randomization (Block size 4 (2A, 2B), allocation:1:1). The doctor and patients did not know in which group they were categorized. Group A received EGb-761 120mg twice daily while group B received placebo (starch) capsule <br> Clinical assessment was done before starting treatment, after two weeks, four weeks, and eight weeks by KOOS questionnaire. KOOS includes 42 items divided into 5 subscales. These are pain, symptoms, ADL, sport and recreational activity, and finally QOL associated with knee activity <br>
DOI: 10.6084/m9.figshare.21259335.v1
title: data.xlsx

description: <br> The study was registered in and approved from the Medical Ethics Committee in the University of Kufa, college of medicine with reference: (MEC_13). The study protocol was registered in ClincialTrials.gov (identifier: <strong>NCT05398874</strong><strong>)</strong>. Participants were asked to sign a printed informed consent that explained the aim of study. This was a randomized double blinded clinical trial conducted in a private orthopaedic clinic in Al-Najaf Government in Iraq from November 1st 2021 to June 1st 2022. The doctor of clinic defined the patients that can be enrolled in the study and informed them about aim of study and take oral and written consent from them. Then the researcher randomized patients into two groups using simple randomization (Block size 4 (2A, 2B), allocation:1:1). The doctor and patients did not know in which group they were categorized. Group A received EGb-761 120mg twice daily while group B received placebo (starch) capsule <br> Clinical assessment was done before starting treatment, after two weeks, four weeks, and eight weeks by KOOS questionnaire. KOOS includes 42 items divided into 5 subscales. These are pain, symptoms, ADL, sport and recreational activity, and finally QOL associated with knee activity <br>
DOI: 10.5517/ccdc.csd.cc2ckwnh
title: CCDC 2191937: Experimental Crystal Structure Determination

description: Related Article: Alex Lovstedt, Steven Kass, George F. Riegel, Keiji Takashige|2022|J.Phys.Org.Chem.|35|e4355|doi:10.1002/poc.4355
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.6084/m9.figshare.21259113
title: Murphy et al 2022 data files

description: Data files from "A tool for monitoring cell type specific focused ultrasound neuromodulation and control of chronic epilepsy" Murphy et al 2022
DOI: 10.6084/m9.figshare.21259113.v1
title: Murphy et al 2022 data files

description: Data files from "A tool for monitoring cell type specific focused ultrasound neuromodulation and control of chronic epilepsy" Murphy et al 2022
DOI: 10.5281/zenodo.7138853
title: Reconstruction of Roman Relics

description: A dataset that consists of various sculptures and artifacts found around Rome. The images are used for SfM reconstruction of the artifcats.
DOI: 10.5281/zenodo.7138852
title: Reconstruction of Roman Relics

description: A dataset that consists of various sculptures and artifacts found around Rome. The images are used for SfM reconstruction of the artifcats.
DOI: 10.5281/zenodo.7138935
title: Analysis code and data for "End-to-end study of the host galaxy and genealogy of GW170817 with BPASS"

description: This folder contains the code and data required to reproduce all figures and values presented in the study titled "End-to-end study of the host galaxy and genealogy of GW170817 with BPASS". The running of the data analysis jupyter notebooks will require the installation of the python package "hoki" v1.7 and the download of the BPASS models that are already publically available. The README.md file contains all the information regarding the dependencies of this directory. Should you need assistance please email hfstevance@gmail.com
DOI: 10.5281/zenodo.7138934
title: Analysis code and data for "End-to-end study of the host galaxy and genealogy of GW170817 with BPASS"

description: This folder contains the code and data required to reproduce all figures and values presented in the study titled "End-to-end study of the host galaxy and genealogy of GW170817 with BPASS". The running of the data analysis jupyter notebooks will require the installation of the python package "hoki" v1.7 and the download of the BPASS models that are already publically available. The README.md file contains all the information regarding the dependencies of this directory. Should you need assistance please email hfstevance@gmail.com
DOI: 10.5281/zenodo.7108327
title: Data set for "The effect of pulling and twisting forces on chameleon sequence peptides"

description: Data set for the publication "The effect of pulling and twisting forces on chameleon sequence peptides"<br> <br> The data contains all energy landscapes explored, structures extracted and analysed, and the necessary utility scripts, written by James Meadows. The README details which data is in each directory. The image directory contains the disconnectivity graphs associated with this data.
DOI: 10.5281/zenodo.7108326
title: Data set for "The effect of pulling and twisting forces on chameleon sequence peptides"

description: Data set for the publication "The effect of pulling and twisting forces on chameleon sequence peptides"<br> <br> The data contains all energy landscapes explored, structures extracted and analysed, and the necessary utility scripts, written by James Meadows. The README details which data is in each directory. The image directory contains the disconnectivity graphs associated with this data.
DOI: 10.5281/zenodo.7125285
title: Effects of meal time feeding

description: Muhammad is a PhD student, working in EU funded project called MonoGutHealth.
DOI: 10.5281/zenodo.7125309
title: Effects of meal time feeding

description: Muhammad is a PhD student, working in EU funded project called MonoGutHealth.
DOI: 10.5281/zenodo.7125286
title: effects of meal and time

description: Muhammad is a PhD student, working in EU funded project called MonoGutHealth.
DOI: 10.5281/zenodo.6658134
title: Transcriptome data of social defeat stress of various durations

description: Data of meta-analysis of transcriptomic changes in the PFC after SDS of various durations. This analysis enabled us to identify clusters of the most reproducible changes in gene expression after 10 and 30 days of SDS and to determine which genes are associated with susceptibility and resistance to SDS after 10 days. Furthermore, we compared such changes in mice after SDS of various durations with data from a meta-analysis of postmortem transcriptomes of the dorsolateral PFC from depressed patients and data of the transcriptomic study on the PFC from patients with PTSD.
DOI: 10.5281/zenodo.6658135
title: Transcriptome data of social defeat stress of various durations

description: Data of meta-analysis of transcriptomic changes in the PFC after SDS of various durations. This analysis enabled us to identify clusters of the most reproducible changes in gene expression after 10 and 30 days of SDS and to determine which genes are associated with susceptibility and resistance to SDS after 10 days. Furthermore, we compared such changes in mice after SDS of various durations with data from a meta-analysis of postmortem transcriptomes of the dorsolateral PFC from depressed patients and data of the transcriptomic study on the PFC from patients with PTSD.
DOI: 10.5281/zenodo.6908429
title: Transcriptome data of social defeat stress of various durations

description: Data of meta-analysis of transcriptomic changes in the PFC after SDS of various durations. This analysis enabled us to identify clusters of the most reproducible changes in gene expression after 10 and 30 days of SDS and to determine which genes are associated with susceptibility and resistance to SDS after 10 days. Furthermore, we compared such changes in mice after SDS of various durations with data from a meta-analysis of postmortem transcriptomes of the dorsolateral PFC from depressed patients and data of the transcriptomic study on the PFC from patients with PTSD.
DOI: 10.5281/zenodo.7139041
title: Transcriptome data of social defeat stress of various durations

description: Data of meta-analysis of transcriptomic changes in the PFC after SDS of various durations. This analysis enabled us to identify clusters of the most reproducible changes in gene expression after 10 and 30 days of SDS and to determine which genes are associated with susceptibility and resistance to SDS after 10 days. Furthermore, we compared such changes in mice after SDS of various durations with data from a meta-analysis of postmortem transcriptomes of the dorsolateral PFC from depressed patients and data of the transcriptomic study on the PFC from patients with PTSD.
DOI: 10.3886/e120065v2-128360
title: Data and Code for: Hunger and the Gender Gap

description: Temporary changes in biological state, such as hunger, can impact decision making differently for men and women. Food scarcity is correlated with a host of negative economic outcomes. Two explanations for this correlation are that hunger affects economic preferences directly or that hunger creates a mindset that focuses on scarcity management to the detriment of other decisions. To test these predictions, we conduct a lab-in-the-feld experiment in a health screening clinic in Shanghai, recruiting participants who finish their annual physical exam either before or after they have eaten breakfast. We compare the hungry and sated groups on their risk, time and generosity preferences as well as their cognitive performance. Our results show that men and women respond to hunger in opposite directions, thus hunger reduces the gender gap in decision quality, risk aversion and cognitive performance, but creates one in generosity. Finally, we examine several biomarkers and find that higher blood lipid levels are correlated with greater choice inconsistency, risk aversion and generosity. We contribute to emerging insights on the biological foundations for economic preferences and outcomes
description: individuals visiting one of the health screening clinics of the company MeiNian.
description: The experiment was conducted immediately after the employee annual physical at a health clinic in Shanghai.
DOI: 10.34740/kaggle/dsv/4277849
title: UNET Lung Segmentation Weights for Chest X Rays