cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.15468/dl.qd7pjd
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Year is greater than or equal to 1980",
 "ScientificName is one of (1043110, 1043647, 1185121, 1187476, 1205635, 1240722, 1317314, 1320787, 1349889, 1385478, 1406929, 1551602, 1554693, 1586570, 1622583, 1673418, 1760927, 1780150, 1783323, 1788425, 1841946, 1846439, 1891701, 1912119, 2031844, 2049579, 2054672, 2056745, 2070879, 2071387, 2074985, 2076178, 2076211, 2077213, 2077747, 2089833, 2149064, 2171960, 2172103, 2173236, 2173887, 2177741, 2296807, 2307593, 2368319, 2373122, 2398535, 2441212, 2570319, 2578737, 2712277, 2712456, 2725082, 2765625, 2891782, 3197970, 3203614, 4290100, 4292492, 4390981, 4410412, 4484307, 4487612, 4532122, 4651573, 4729629, 4799919, 5019591, 5081869, 5157899, 5161881, 5161941, 5162519, 5190459, 5204099, 5239341, 5423446, 5716338, 5731736, 5758819, 5843310, 5865936, 5866314, 5871429, 5892137, 6130380, 7517009, 7592046, 7699709, 7704981, 7999703, 8088000, 8090087, 8095272, 8602203, 9268470, 9325778, 9456300, 9492838, 9649446, 9692339, 10058520, 10069196, 10521098, 10928934)",
 "BasisOfRecord is one of (Human Observation, Observation, Specimen)",
 "HasCoordinate is true"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0043964-250525065834625/datasets/export for details.
DOI: 10.25824/redu/cejlrp
title: Sound attenuation of a periodic array of micro-perforated chamber muffler

description: Database and figures obtained from the doctoral thesis on Sound attenuation of a periodic array of micro-perforated chamber muffler. The data comprises the analyzed results for the following cases: 1 - *ECM Defect Mode: Analysis of defect modes in expansion chambers 2 - CNN MPCM: Results for inverse optimization of micro-perforated expansion chambers using convolutional neural networks 3 - MPCM Graded Diameter: Analysis of micro-perforated expansion chambers with graded outer diameter 4 - MPCM Graded Internal: Analysis of micro-perforated expansion chambers with graded internal micro-perforation diameter 5 - All results uploaded are in MATLAB figure format extension (.fig)MPCM Graded Perforation: Analysis of micro-perforated expansion chambers with graded perforation diameter
DOI: 10.15468/dl.9f7a93
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Askidiosperma nitidum (Mast.) H.Linder",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "BasisOfRecord is one of (Specimen, Living Specimen, Observation, Human Observation, Machine Observation, Material sample, Literature Occurrence, Material citation, Occurrence evidence)",
 "Geometry POLYGON ((32.064 -28.9416,32.4847 -28.5786,30.5701 -28.5786,30.5701 -30.7329,30.6252 -30.6659,31.4179 -29.4257,31.8178 -29.0299,32.064 -28.9416))"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0043965-250525065834625/datasets/export for details.
DOI: 10.15468/dl.t4bftn
title: Occurrence Download

description: A dataset containing 5 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Cymbella cymbiformis C.Agardh, 1830",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "BasisOfRecord is one of (Specimen, Living Specimen, Observation, Human Observation, Machine Observation, Material sample, Literature Occurrence, Material citation, Occurrence evidence)",
 "Geometry POLYGON ((30.5701 -24.0715,25.5395 -24.0715,25.5395 -28.5786,30.5701 -28.5786,30.5701 -24.0715))"
 ]
}

 The dataset includes 5 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0043966-250525065834625/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.3886/e155161v81
title: Advance Layoff Notice Data from the WARN Act

description: We collect novel and timely data from advance layoff notices filed under the Worker Adjustment and Retraining Notification (WARN) Act. The act requires larger employers to notify affected workers at least 60 days before a potential mass layoff. We assemble WARN data from across the United States, and for many large states our data begin in the 1990s. We aggregate these data into an unbalanced, monthly panel of the state-level number of workers affected by WARN notices, and we update this panel twice a month. We also aggregate this panel to a national-level indicator of job loss (the "WARN factor") using a dynamic factor model.<br>

<b><br>Data Collection</b><br>We update the data twice a month by collecting WARN
notices from state websites. For many states, we have extended our historical
data by using digital archives of the internet and contacting state
officials.<br> <br><b>Citation</b><br>To learn more about
the data and the dynamic factor model, see:<br>Krolikowski, Pawel M. and Kurt G. Lunsford. 2022. “Advance Layoff Notices and Aggregate Job Loss.” Federal Reserve Bank of Cleveland, Working Paper no. 20-03R. https://doi.org/10.26509/frbc-wp-202003R.<br>Krolikowski, Pawel M., and Kurt G. Lunsford. 2024 “Advance Layoff Notices and Aggregate Job Loss.” Journal of Applied Econometrics. https://doi.org/10.1002/jae.3032.<b><br><br></b><b>File Description</b><br>The file labelled WARNFiles_YYYYMMDD.zip in the
main directory contains our most recent data. All data included in this zip
file were collected as of the date listed in the file name. Previous
vintages of our data appear in the `Archived_Vintages’ folder, with the same
naming convention.<br>
<br>The zip files contain three files:<br>
<br>


1. 
README.txt

<br>2. 
WARNData_NSA_YYYYMMDD.csv


 
 This .csv contains the number of workers affected by
 WARN notices by state and month. These data are not seasonally adjusted.
 These data are the input into the dynamic factor model.
 


3. 
WARNFactors_YYYYMMDD.csv


 
 This .csv contains the output of the dynamic factor
 model. The output is labeled as follows:
 
 WARN Factor: the estimates of the factor from the
 dynamic factor model.
 MSE: the estimated mean squared errors
 of the WARN factor.
 WARN_hat: the number of workers affected by
 WARN notices as implied by the WARN factor.
 WARN_sum: the sum of the number of
 workers affected by WARN notices from several states that form a
 balanced panel beginning in January 2006. These states can change every
 update.<b>Disclaimer</b><br>These data are
updated by the authors and are not an official product of the Federal Reserve Bank of Cleveland.<br>
description: Smallest Geographic Unit: State
DOI: 10.15468/dl.qb367q
title: Occurrence Download

description: A dataset containing 10425 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Notropis texanus (Girard, 1856)"
 ]
}

 The dataset includes 10425 records from 52 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0043967-250525065834625/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.25345/c58g8fw4t
title: MassIVE MSV000098191 - Human tissue cultures if HT29 and HepG2, grown under incubation with small molecules
title: Human colon adenocarcinoma cells (HT29) and liver hepatocytes (HepG2) cultured with incubation of small molecules for 48hrs. The tissues were extracted using 50:50 (MeOH:H2O) for metabolomics analysis.
DOI: 10.48597/wkq5-3kdj
title: Nitrogen_monoxide at Beromünster

description: Measurement of Nitrogen_monoxide at Beromünster
DOI: 10.48597/x3wx-gwug
title: Measurement of Nitrogen_monoxide at Beromünster

description: Measurement of Nitrogen_monoxide at Beromünster
DOI: 10.48597/jwuz-z4dd
title: Measurement of Nitrogen_monoxide at Beromünster

description: Measurement of Nitrogen_monoxide at Beromünster
DOI: 10.48597/hdk5-a2g5
title: Measurement of Nitrogen_monoxide at Beromünster

description: Measurement of Nitrogen_monoxide at Beromünster
DOI: 10.15468/dl.2mq955
title: Occurrence Download

description: A dataset containing 2 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Continent is South America",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "TaxonKey is Deschampsia setacea (Huds.) Hack.",
 "Year 1930-2025"
 ]
}

 The dataset includes 2 records from 2 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0043970-250525065834625/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.8b7dfz
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Cymbella cymbiformis C.Agardh, 1830",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "BasisOfRecord is one of (Specimen, Living Specimen, Observation, Human Observation, Machine Observation, Material sample, Literature Occurrence, Material citation, Occurrence evidence)",
 "Geometry POLYGON ((27.1332 -20.158,25.5395 -23.2724,25.5395 -24.0715,30.5701 -24.0715,30.5701 -20.3186,29.6496 -19.6123,28.947 -19.4003,28.1821 -19.4609,27.6072 -19.7214,27.1332 -20.158))"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0043971-250525065834625/datasets/export for details.
DOI: 10.15468/dl.qmtp9k
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Askidiosperma nitidum (Mast.) H.Linder",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "BasisOfRecord is one of (Specimen, Living Specimen, Observation, Human Observation, Machine Observation, Material sample, Literature Occurrence, Material citation, Occurrence evidence)",
 "Geometry POLYGON ((35.5808 -24.13,35.5909 -24.0715,30.5701 -24.0715,30.5701 -28.5786,32.4847 -28.5786,32.55 -28.5222,33.0346 -26.8668,32.9741 -26.7838,33.0415 -26.059,32.9304 -26.0011,32.7994 -26.1281,32.6834 -26.0015,32.813 -25.8728,32.8513 -25.7166,33.3048 -25.3731,35.1489 -24.6699,35.5808 -24.13))"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0043972-250525065834625/datasets/export for details.
DOI: 10.17043/lindgren-2025-carbon-model-input-1
title: Soil carbon modelling from the Last Glacial Maximum (LGM) to present for the Northern Hemisphere — input data
DOI: 10.34740/kaggle/dsv/12158281
title: IOT EARLY FLOOD DETECTION AND AVOIDANCE SYSTEM
DOI: 10.15468/dl.9kfdz6
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Askidiosperma nitidum (Mast.) H.Linder",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "BasisOfRecord is one of (Specimen, Living Specimen, Observation, Human Observation, Machine Observation, Material sample, Literature Occurrence, Material citation, Occurrence evidence)",
 "Geometry POLYGON ((25.5395 -28.5786,20.509 -28.5786,20.509 -32.9007,25.5395 -32.9007,25.5395 -28.5786))"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0043977-250525065834625/datasets/export for details.
DOI: 10.15468/dl.r2cr6g
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Cymbella cymbiformis C.Agardh, 1830",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "BasisOfRecord is one of (Specimen, Living Specimen, Observation, Human Observation, Machine Observation, Material sample, Literature Occurrence, Material citation, Occurrence evidence)",
 "Geometry POLYGON ((25.0214 -34.0501,25.5395 -34.1098,25.5395 -32.9007,20.509 -32.9007,20.509 -34.5676,20.524 -34.555,20.8859 -34.5419,20.9606 -34.4398,21.2995 -34.5131,21.5296 -34.4338,21.8696 -34.4439,22.0323 -34.2835,22.221 -34.2428,22.2566 -34.1304,22.5993 -34.0741,22.9652 -34.1674,23.4069 -34.1858,23.4955 -34.0792,23.6056 -34.0563,24.8471 -34.2877,24.9447 -34.2397,25.0214 -34.0501))"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0043975-250525065834625/datasets/export for details.
DOI: 10.15468/dl.u976p4
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "DatasetKey is 62fa4e25-a695-4c6e-9b40-ed7e4a3d1ac6",
 "TaxonKey is Plantae",
 "HasCoordinate is true",
 {
 "not" : {
 "Issue" : [
 "is Country coordinate mismatch"
 ]
 }
 },
 {
 "not" : {
 "Issue" : [
 "is Coordinate uncertainty meters invalid"
 ]
 }
 },
 {
 "not" : {
 "Issue" : [
 "is Presumed swapped coordinate"
 ]
 }
 },
 {
 "not" : {
 "Issue" : [
 "is Presumed negated longitude"
 ]
 }
 },
 {
 "not" : {
 "Issue" : [
 "is Presumed negated latitude"
 ]
 }
 }
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0043963-250525065834625/datasets/export for details.
DOI: 10.15468/dl.yztvt4
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Cymbella cymbiformis C.Agardh, 1830",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "BasisOfRecord is one of (Specimen, Living Specimen, Observation, Human Observation, Machine Observation, Material sample, Literature Occurrence, Material citation, Occurrence evidence)",
 "Geometry POLYGON ((32.064 -28.9416,32.4847 -28.5786,30.5701 -28.5786,30.5701 -30.7329,30.6252 -30.6659,31.4179 -29.4257,31.8178 -29.0299,32.064 -28.9416))"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0043979-250525065834625/datasets/export for details.
DOI: 10.15468/dl.4jnkjv
title: Occurrence Download

description: A dataset containing 243386 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Succisa pratensis Moench",
 "OccurrenceStatus is Present",
 "HasGeospatialIssue is false",
 "HasCoordinate is true",
 "Year is greater than or equal to 1900",
 "Year is less than or equal to 2010"
 ]
}

 The dataset includes 243386 records from 590 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0043958-250525065834625/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.433pyh
title: Occurrence Download

description: A dataset containing 1 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Cyperus thunbergii Vahl",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "BasisOfRecord is one of (Specimen, Living Specimen, Observation, Human Observation, Machine Observation, Material sample, Literature Occurrence, Material citation, Occurrence evidence)",
 "Geometry POLYGON ((30.5701 -24.0715,25.5395 -24.0715,25.5395 -28.5786,30.5701 -28.5786,30.5701 -24.0715))"
 ]
}

 The dataset includes 1 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0043980-250525065834625/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.tbfnzy
title: Occurrence Download

description: A dataset containing 554536 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Carex flacca Schreb.",
 "HasCoordinate is true",
 "HasGeospatialIssue is false"
 ]
}

 The dataset includes 554536 records from 2278 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0043960-250525065834625/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.5281/zenodo.15154491
title: Table 1 Key correlations from 2 D in Monoterpene indole alkaloids from Vinca minor L. (Apocynaceae): Identification of new structural scaffold for treatment of Alzheimer's disease

description: Table 1 Key correlations from 2D NMR experiments in the structure elucidation of undescribed alkaloid 9 (HMBC interaction – blue arrow; H2BC and COSY interaction – red bond) and its 1 H and 13 C NMR chemical shifts assigned to the related position in ppm with coupling constants (in parenthesis, reported in Hz)..
Positionvincaminorudeine 9500 MHz, CDCl3125 MHz, CDCl32139.134.39, dd (4.1, 2.7)38.742.63–2.55, m31.11.92, dd (14.3, 4.1)542.961.36–1.21, m31.71.06, td (12.5, 5.5)71.52–1.39, m22.31.36–1.21, m82.38–2.22, m55.2102.63–2.55, m53.62.38–2.22, m113.05–2.85, m22.312110.313127.0147.53, dd (7.8, 1.1)118.1157.09, dd (7.8, 1.1)118.5167.19, dd (7.8, 1.1)120.7177.27, dd (7.8, 1.1)108.618136.7193.75–3.70, m, overlap56.61.64, d (12.5)203.47, q (6.5)74.2211.29, d, overlap (6.5)17.6C= O177.03-COOCH33.72, s, overlap52.7N CH33.54, s30.3
description: Published as part of Vrabec, Rudolf, Ma, Jana, ríkov, a, Loc, Miroslav, arek, Kor, Jan, abe, cný, Hulcova, Daniela, Ho, Anna, st, alkov, a, Ji, Kune, rí, s, Chlebek, Jakub, Toma, Ku, s, cera, Hrabinova, Martina, Jun, Daniel, Ond, Soukup, rej, Andrisano, Vincenza, Jen, Jaroslav, co, Marcela, Safratova, Nov, Lucie, akova, Opletal, Lubomír & Cahlíkova, Lucie, 2022, Monoterpene indole alkaloids from Vinca minor L. (Apocynaceae): Identification of new structural scaffold for treatment of Alzheimer's disease, pp. 4 in Phytochemistry (113017) 194 on page 4, DOI: 10.1016/j.phytochem.2021.113017, http://zenodo.org/record/8240066
DOI: 10.5281/zenodo.15154494
title: Table 2 in Monoterpene indole alkaloids from Vinca minor L. (Apocynaceae): Identification of new structural scaffold for treatment of Alzheimer's disease

description: Table 2 Comparison of experimental NMR data of this work with those presented by Farahanikia et al. (2011) for the very same structure of vincaminoreine 2. The specific optical rotation was consistent with the published one by Farahanikia et al. (2011) and Mokrý et al. (1964). 1 H and 13 C NMR chemical shifts are assigned to the related position in ppm with coupling constants for 1 H NMR (in parenthesis, reported in Hz)..
PositionExperimental vincaminoreine 2published vincaminoreine 2 (Farahanikia et al., 2011)500 MHz, CDCl3125 MHz, CDCl3500 MHz, CDCl3125 MHz, CDCl32139.3139.333.90, dd (4.8, 2.9)38.11.96–1.93, m33.842.46, dd (13.7, 2.9)33.92.95–2.93, m22.51.97, d (13.7)538.124.861.43–1.36, m34.21.35–1.30, m31.01.24–1.12, m1.20–1.18, m71.54–1.44, m22.51.54–1.47, m22.31.35–1.24, m1.29–1.25, m82.38–2.32, m55.32.51–2.49, m53.32.32–2.20, m2.27–2.24, m102.55–2.50, m53.32.33–2.29, m55.32.32–2.20, m2.29–2.27, m113.00–2.89, m22.31.41–1.36, m34.21.18–1.16, m12110.0110.013127.1127.1147.50, dd (7.8, 1.0)118.07.50, d (7.1)118.0157.18, td (7.8, 1.0)118.57.17, t (7.0)120.6167.09, td (7.8, 1.0)120.67.07, t (7.0)118.5177.26, dd (7.8, 1.0)108.67.24, overlap108.618136.8136.7193.16, d (12.5)57.93.16, d (15.0)57.91.61, d (12.5)1.61, d (15.0)201.35–1.24, m31.01.25–1.20, m14.21.24–1.12, m210.95, t (7.5)7.40.93, t (7.2)7.4C= O175.2175.23-COOCH33.71, s52.53.70, s52.5NCH33.54, s30.23.52, s30.2[a]D+ 27.6 (c 0.18, CHCl3)+ 26.5 (CHCl3)(Farahanikia et al., 2011; Mokrý et al., 1964)
description: Published as part of Vrabec, Rudolf, Ma, Jana, ríkov, a, Loc, Miroslav, arek, Kor, Jan, abe, cný, Hulcova, Daniela, Ho, Anna, st, alkov, a, Ji, Kune, rí, s, Chlebek, Jakub, Toma, Ku, s, cera, Hrabinova, Martina, Jun, Daniel, Ond, Soukup, rej, Andrisano, Vincenza, Jen, Jaroslav, co, Marcela, Safratova, Nov, Lucie, akova, Opletal, Lubomír & Cahlíkova, Lucie, 2022, Monoterpene indole alkaloids from Vinca minor L. (Apocynaceae): Identification of new structural scaffold for treatment of Alzheimer's disease, pp. 6 in Phytochemistry (113017) 194 on page 6, DOI: 10.1016/j.phytochem.2021.113017, http://zenodo.org/record/8240066
DOI: 10.5281/zenodo.15154498
title: Table 3 in Monoterpene indole alkaloids from Vinca minor L. (Apocynaceae): Identification of new structural scaffold for treatment of Alzheimer's disease

description: Table 3 Biological activities of isolated Vinca minor alkaloids.
CompoundIC50 h AChE ± SEM (μM) aIC50 h BuChE ± SEM (μM) aIC50 POP ± SEM (μM) a% inhibition of GSK-3β SEM b ±logBB cPAMPA (P e; 10 6 cm s 1)dvincaminorine (1)> 100> 100429 ± 30–n.c.–vincaminoreine (2)> 1008.71 ± 0.49408 ± 60–0.262–eburnamonine (3)> 10093.49 ± 15.90n.d.–n.c.–minovine (4)> 10026.32 ± 2.52n.d.–n.c.–16-methoxyminovine (5)> 10025.01 ± 3.27n.t.–n.c.–vincatine (6)> 10043.47 ± 3.30n.d.–n.c.–minovincine (7)> 100> 100301 ± 15–n.c.–16-methoxyminovincine (8)> 100> 100n.d.–n.c.–vincaminorudeine (9)> 10084.91 ± 2.98n.d.–n.c.–demethoxyalstonamide (10)> 10056.38 ± 2.58n.d.–n.c.–vincorine (11)> 1009.75 ± 0.45n.t.–0.022–minovincinine (12)> 100> 100n.d.–n.c.–aspidospermidine (13)> 10033.60 ± 1.52n.d.–n.c.–19-oxoeburnamonine (14)> 100> 100n.t.–n.c.–akuammicine (15)> 10038.17 ± 0.84n.t.–n.c.–tubotaiwine (16)> 10011.70 ± 0.11n.d.–n.c.–raucubainine (17)> 10093.96 ± 6.80> 500–n.c.–aspidofractinine (18)> 100> 100n.d.–n.c.–2-ethyl-3[2-(3-ethylpiperidinyl)-ethyl]-1 H -> 1000.650 ± 0.01658 ± 431.43 ± 3.05¡0.16415.7 ± 1.3 (CNSþ)indole (19)dihydrovindolinine (20)> 100> 100n.d.–n.c.–strictamine (21)> 100> 100190 ± 11–n.c.–5-oxoaspidofractinine (22)> 100> 100n.t.–n.c.–raucubaine (23)> 100> 100n.t.–n.c.–galanthamine e1.72 ± 0.1242 ± 1––0.0475.1 (CNS) f +eserine e0.063 ± 0.0050.13 ± 0.01––0.177–berberine e0.72 ± 0.1131 ± 4142 ± 21–0.420–chlorothiazide e––––0.4181.1 ± 0.5 (CNS)
a Compound concentration required to decrease enzyme activity by 50%; the values are the mean SEM of three independent measurements, each performed in ± triplicate.
b Measured at a concentration of 100 μM.
c calculated at http://www.way2drug.com/geb.
d CNS(): high BBB permeation predicted with P (10 6 cm s 1)> 4.0, CNS(): low BBB permeation predicted with P (10 6 cm s 1) <2.0, CNS(): BBB permeation + e e ± uncertain with P (10 6 cm s 1) from 4.0 to 2.0.
e e Reference compound; f Taken from reference (Stavrakov et al., 2017); n.t. stands for not tested due to the isolation of low amount; n.d. stands for not measurable due to a problem with solubility; n.c. stands for not calculated.
description: Published as part of Vrabec, Rudolf, Ma, Jana, ríkov, a, Loc, Miroslav, arek, Kor, Jan, abe, cný, Hulcova, Daniela, Ho, Anna, st, alkov, a, Ji, Kune, rí, s, Chlebek, Jakub, Toma, Ku, s, cera, Hrabinova, Martina, Jun, Daniel, Ond, Soukup, rej, Andrisano, Vincenza, Jen, Jaroslav, co, Marcela, Safratova, Nov, Lucie, akova, Opletal, Lubomír & Cahlíkova, Lucie, 2022, Monoterpene indole alkaloids from Vinca minor L. (Apocynaceae): Identification of new structural scaffold for treatment of Alzheimer's disease, pp. 7 in Phytochemistry (113017) 194 on page 7, DOI: 10.1016/j.phytochem.2021.113017, http://zenodo.org/record/8240066