cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.5281/zenodo.5912286
title: Labeled Images of Sand and Coins

description: The dataset consists of images and associated binary masks, as well as augmented images and associated masks. Images depict sand and coins. Masks depict the coin (white) against a sand background (black). There are 132 augmented images and 132 images and associated labels in jpg format The principal purpose is to provide a dataset to help train a model or design an algorithm to segment the image from the coin background
DOI: 10.5281/zenodo.5899716
title: NC fractionation set2 - 2 replicates

description: TBD220012_14167_20220117 NC fractionation set2 - 2 replicates
DOI: 10.5281/zenodo.5899715
title: NC fractionation set2 - 2 replicates

description: TBD220012_14167_20220117 NC fractionation set2 - 2 replicates
DOI: 10.6084/m9.figshare.19085150
title: Supplementary Material for: A Novel Homozygous <b><i>KLHL3</i></b> Mutation as a Cause of Autosomal Recessive Pseudohypoaldosteronism Type II Diagnosed Late in Life

description: <b><i>Introduction:</i></b> Pseudohypoaldosteronism type II (PHA II) is a Mendelian disorder, featuring hyperkalemic acidosis and low plasma renin levels, typically associated with hypertension. Mutations in <i>WNK1</i>, <i>WNK4</i>, <i>CUL3</i>, and <i>KLHL3</i> cause PHA II, with dominant mutations in <i>WNK1</i>, <i>WNK4</i>, and <i>CUL3</i> and either dominant or recessive mutations in <i>KLHL3</i>. Fourteen families with recessive <i>KLHL3</i> mutations have been reported, with diagnosis at the age of 3 months to 56 years, typically in individuals with normal kidney function. <b><i>Methods:</i></b> We performed clinical and genetic investigations in a patient with hyperkalemic hypertension and used molecular dynamics simulations, heterologous expression in COS7 cells, and Western blotting to investigate the effect of a <i>KLHL3</i> candidate disease mutation on WNK4 protein expression. <b><i>Results:</i></b> The patient, a 58-year-old woman from a consanguineous family, showed hypertension, persistent hyperkalemic acidosis associated with severe muscle pain, nephrolithiasis, chronic kidney disease (CKD), and coronary heart disease. Therapy with hydrochlorothiazide corrected hyperkalemia, hypertension, and muscle pain. Genetic analysis revealed a homozygous p.Arg431Trp mutation at a highly conserved KLHL3 position. Simulations suggested reduced stability of the mutant protein, which was confirmed by Western blot. Compared with wild-type KLHL3, cotransfection of p.Arg431Trp KLHL3 led to increased WNK4 protein levels, inferred to cause increased NaCl reabsorption via the thiazide-sensitive carrier and PHA II. <b><i>Conclusions:</i></b> Even in patients presenting late in life and in the presence of CKD, PHA II should be suspected if renin levels are low and hyperkalemic acidosis and hypertension are inadequate for CKD stage, particularly in the presence of a suspicious family history.
DOI: 10.6084/m9.figshare.19085176
title: Additional file 1 of Genome-wide association study for seedling biomass-related traits in Gossypium arboreum L.

description: Additional file 1: Table S1. Primer sequences of selected genes used for qRT-PCR assay in this study. Table S2. Phenotypes of 11 seedling biomass-related traits in 215 G. arboreum accessions. Table S3. Basic descriptive analysis for seedling biomass-related traits. Table S4. Summary of SNPs that detected in 11 seedling biomass-related traits. Table S5. Significant SNPs identified for the seedling biomass-related traits. Table S6. 69 candidate genes associated with seedling biomass-related traits identified by GWAS. Table S7. FPKM of the GWAS candidate genes in 4 representative cotton accessions. Table S8. TPM of the GWAS candidate genes in Shixiya-1.
DOI: 10.6084/m9.figshare.19085176.v1
title: Additional file 1 of Genome-wide association study for seedling biomass-related traits in Gossypium arboreum L.

description: Additional file 1: Table S1. Primer sequences of selected genes used for qRT-PCR assay in this study. Table S2. Phenotypes of 11 seedling biomass-related traits in 215 G. arboreum accessions. Table S3. Basic descriptive analysis for seedling biomass-related traits. Table S4. Summary of SNPs that detected in 11 seedling biomass-related traits. Table S5. Significant SNPs identified for the seedling biomass-related traits. Table S6. 69 candidate genes associated with seedling biomass-related traits identified by GWAS. Table S7. FPKM of the GWAS candidate genes in 4 representative cotton accessions. Table S8. TPM of the GWAS candidate genes in Shixiya-1.
DOI: 10.6084/m9.figshare.19085203
title: Additional file 1 of Antihypertensive effects of yoga in a general patient population: real-world evidence from electronic health records, a retrospective case-control study

description: Additional file 1. List of ICD codes. ICD codes of comorbidities most common to hypertension and identified in this data set.
DOI: 10.6084/m9.figshare.19085209.v1
title: Additional file 2 of Antihypertensive effects of yoga in a general patient population: real-world evidence from electronic health records, a retrospective case-control study

description: Additional file 2. List of drugs. Antihypertensives, beta blockers, calcium-channel blockers and diuretics identified in this data set.
DOI: 10.6084/m9.figshare.19085209
title: Additional file 2 of Antihypertensive effects of yoga in a general patient population: real-world evidence from electronic health records, a retrospective case-control study

description: Additional file 2. List of drugs. Antihypertensives, beta blockers, calcium-channel blockers and diuretics identified in this data set.
DOI: 10.6084/m9.figshare.19085203.v1
title: Additional file 1 of Antihypertensive effects of yoga in a general patient population: real-world evidence from electronic health records, a retrospective case-control study

description: Additional file 1. List of ICD codes. ICD codes of comorbidities most common to hypertension and identified in this data set.
DOI: 10.6084/m9.figshare.19085173.v1
title: Additional file 10 of Genome-scale CRISPR screens identify host factors that promote human coronavirus infection

description: Additional file 10. Reanalysis of published human CRISPR screen data sets.
DOI: 10.6084/m9.figshare.19085173
title: Additional file 10 of Genome-scale CRISPR screens identify host factors that promote human coronavirus infection

description: Additional file 10. Reanalysis of published human CRISPR screen data sets.
DOI: 10.6084/m9.figshare.19085185
title: Additional file 2 of Genome-scale CRISPR screens identify host factors that promote human coronavirus infection

description: Additional file 2. AGM CRISPR KO sgRNAs.
DOI: 10.6084/m9.figshare.19085185.v1
title: Additional file 2 of Genome-scale CRISPR screens identify host factors that promote human coronavirus infection

description: Additional file 2. AGM CRISPR KO sgRNAs.
DOI: 10.6084/m9.figshare.19085188.v1
title: Additional file 3 of Genome-scale CRISPR screens identify host factors that promote human coronavirus infection

description: Additional file 3. Raw and normalized counts for each CRISPR screen performed in this study.
DOI: 10.6084/m9.figshare.19085200
title: Additional file 4 of Genome-scale CRISPR screens identify host factors that promote human coronavirus infection

description: Additional file 4. VERO E6 SARS-CoV-2 study analysis.
DOI: 10.6084/m9.figshare.19085188
title: Additional file 3 of Genome-scale CRISPR screens identify host factors that promote human coronavirus infection

description: Additional file 3. Raw and normalized counts for each CRISPR screen performed in this study.
DOI: 10.6084/m9.figshare.19085200.v1
title: Additional file 4 of Genome-scale CRISPR screens identify host factors that promote human coronavirus infection

description: Additional file 4. VERO E6 SARS-CoV-2 study analysis.
DOI: 10.6084/m9.figshare.19085206
title: Additional file 5 of Genome-scale CRISPR screens identify host factors that promote human coronavirus infection

description: Additional file 5. VERO E6 OC43 study analysis.
DOI: 10.6084/m9.figshare.19085218
title: Additional file 7 of Genome-scale CRISPR screens identify host factors that promote human coronavirus infection

description: Additional file 7. HEK293T-Ace2 SARS-CoV-2 CRISPR Study 2 analysis.
DOI: 10.6084/m9.figshare.19085212
title: Additional file 6 of Genome-scale CRISPR screens identify host factors that promote human coronavirus infection

description: Additional file 6. HEK293T-Ace2 SARS-CoV-2 CRISPR Study 1 analysis.
DOI: 10.6084/m9.figshare.19085212.v1
title: Additional file 6 of Genome-scale CRISPR screens identify host factors that promote human coronavirus infection

description: Additional file 6. HEK293T-Ace2 SARS-CoV-2 CRISPR Study 1 analysis.
DOI: 10.6084/m9.figshare.19085218.v1
title: Additional file 7 of Genome-scale CRISPR screens identify host factors that promote human coronavirus infection

description: Additional file 7. HEK293T-Ace2 SARS-CoV-2 CRISPR Study 2 analysis.
DOI: 10.6084/m9.figshare.19085206.v1
title: Additional file 5 of Genome-scale CRISPR screens identify host factors that promote human coronavirus infection

description: Additional file 5. VERO E6 OC43 study analysis.
DOI: 10.6084/m9.figshare.19085221
title: Additional file 8 of Genome-scale CRISPR screens identify host factors that promote human coronavirus infection

description: Additional file 8. HEK293T-Ace2 OC43 CRISPR study analysis.
DOI: 10.6084/m9.figshare.19085224
title: Additional file 9 of Genome-scale CRISPR screens identify host factors that promote human coronavirus infection

description: Additional file 9. Summaries of HEK293T-Ace2 and VERO E6 screens with SARS-CoV-2 and OC43.
DOI: 10.6084/m9.figshare.19085224.v1
title: Additional file 9 of Genome-scale CRISPR screens identify host factors that promote human coronavirus infection

description: Additional file 9. Summaries of HEK293T-Ace2 and VERO E6 screens with SARS-CoV-2 and OC43.
DOI: 10.6084/m9.figshare.19085221.v1
title: Additional file 8 of Genome-scale CRISPR screens identify host factors that promote human coronavirus infection

description: Additional file 8. HEK293T-Ace2 OC43 CRISPR study analysis.
DOI: 10.6084/m9.figshare.19085242.v1
title: Additional file 14 of The visual pathway in sea spiders (Pycnogonida) displays a simple serial layout with similarities to the median eye pathway in horseshoe crabs

description: Additional file 14: Table S2: Overview of protocerebral sense organs and brain structures identified across pycnogonid families, with details on immunoreactivity for neuroactive substances.
DOI: 10.6084/m9.figshare.19085248
title: Additional file 1 of The visual pathway in sea spiders (Pycnogonida) displays a simple serial layout with similarities to the median eye pathway in horseshoe crabs

description: Additional file 1: Table S1: List of species studied, collection sites and methods applied.
DOI: 10.6084/m9.figshare.19085242
title: Additional file 14 of The visual pathway in sea spiders (Pycnogonida) displays a simple serial layout with similarities to the median eye pathway in horseshoe crabs

description: Additional file 14: Table S2: Overview of protocerebral sense organs and brain structures identified across pycnogonid families, with details on immunoreactivity for neuroactive substances.
DOI: 10.6084/m9.figshare.19085248.v1
title: Additional file 1 of The visual pathway in sea spiders (Pycnogonida) displays a simple serial layout with similarities to the median eye pathway in horseshoe crabs

description: Additional file 1: Table S1: List of species studied, collection sites and methods applied.
DOI: 10.6084/m9.figshare.19085341
title: Additional file 1 of Florigen and its homologs of FT/CETS/PEBP/RKIP/YbhB family may be the enzymes of small molecule metabolism: review of the evidence

description: Additional file 1: Supplemental Data Set 1. Newick-formatted phylogenetic tree of FT/YbhB homologs in bacteria, archaea and eukaryotes.
DOI: 10.6084/m9.figshare.19085341.v1
title: Additional file 1 of Florigen and its homologs of FT/CETS/PEBP/RKIP/YbhB family may be the enzymes of small molecule metabolism: review of the evidence

description: Additional file 1: Supplemental Data Set 1. Newick-formatted phylogenetic tree of FT/YbhB homologs in bacteria, archaea and eukaryotes.
DOI: 10.6084/m9.figshare.19085344
title: Additional file 2 of Florigen and its homologs of FT/CETS/PEBP/RKIP/YbhB family may be the enzymes of small molecule metabolism: review of the evidence

description: Additional file 2: Supplemental Data Set 2. List of ligand-binding domains in PFAM and their usage of conserved amino acid residues.
DOI: 10.6084/m9.figshare.19085344.v1
title: Additional file 2 of Florigen and its homologs of FT/CETS/PEBP/RKIP/YbhB family may be the enzymes of small molecule metabolism: review of the evidence

description: Additional file 2: Supplemental Data Set 2. List of ligand-binding domains in PFAM and their usage of conserved amino acid residues.
DOI: 10.6084/m9.figshare.19085347
title: Additional file 3 of Florigen and its homologs of FT/CETS/PEBP/RKIP/YbhB family may be the enzymes of small molecule metabolism: review of the evidence

description: Additional file 3: Supplemental Data Set 3. Occurrences of the motif with consensus sequence TACACTT in Enterobacteriaceae.
DOI: 10.6084/m9.figshare.19085347.v1
title: Additional file 3 of Florigen and its homologs of FT/CETS/PEBP/RKIP/YbhB family may be the enzymes of small molecule metabolism: review of the evidence

description: Additional file 3: Supplemental Data Set 3. Occurrences of the motif with consensus sequence TACACTT in Enterobacteriaceae.
DOI: 10.6084/m9.figshare.19085362
title: Additional file 2 of An advanced method for the release, enrichment and purification of high-quality Arabidopsis thaliana rosette leaf trichomes enables profound insights into the trichome proteome

description: Additional file 2: Data S1. Overview of the proteomics data.
DOI: 10.6084/m9.figshare.19085362.v1
title: Additional file 2 of An advanced method for the release, enrichment and purification of high-quality Arabidopsis thaliana rosette leaf trichomes enables profound insights into the trichome proteome

description: Additional file 2: Data S1. Overview of the proteomics data.
DOI: 10.6084/m9.figshare.17031045.v1
title: Additional file 4 of Focal adhesion kinase inhibitor TAE226 combined with Sorafenib slows down hepatocellular carcinoma by multiple epigenetic effects

description: Additional file 4: Table S4. Nuclear interactors of FAK.
DOI: 10.6084/m9.figshare.17031045
title: Additional file 4 of Focal adhesion kinase inhibitor TAE226 combined with Sorafenib slows down hepatocellular carcinoma by multiple epigenetic effects

description: Additional file 4: Table S4. Nuclear interactors of FAK.
DOI: 10.6084/m9.figshare.19085165
title: Original data

description: SMARCD1; microRNA; lncRNA肝细胞癌;
DOI: 10.6084/m9.figshare.19085165.v1
title: Original data

description: SMARCD1; microRNA; lncRNA肝细胞癌;
DOI: 10.6084/m9.figshare.19085417
title: Supplementary Material for: Instrumented Functional Test for Objective Outcome Evaluation of Balance Rehabilitation in Elderly Fallers: A Clinical Study

description: <b><i>Introduction:</i></b> Observational tests, e.g., the Berg Balance Scale (BBS) are widely used for balance evaluation in the elderly fallers. However, they do not allow objective outcome evaluation of rehabilitative interventions. This study aimed to investigate, in a clinical setting, the use of inertial measurement units (IMUs) integrated into the BBS test for objective outcome evaluation of balance rehabilitation in elderly fallers compared to conventional BBS scores. <b><i>Methods:</i></b> Thirty-six elderly fallers were recruited from the in-patient population of a geriatrics Clinic. Participants performed the BBS test while wearing 3 IMUs placed on the sternum, sacrum, and tibia of the dominant leg following admission to the clinic. Subsequently, they completed a rehabilitation program for 2–4 weeks. They performed a similar test before their discharge. The physical therapist recorded the BBS scores at both sessions, and the sensor data of the 2-min quiet standing task (BBS task 2) were extracted for objective balance evaluation. Moreover, eleven young adults were recruited to perform a 2-min quiet standing test while wearing the same IMUs. Center-of-pressure (COP) and segmental center-of-mass (COM) accelerations were calculated to estimate time-domain, frequency-domain, and intersegment coordination biomarkers of balance. <b><i>Results:</i></b> COP time- and frequency-domain measures, COM acceleration time-domain measures, and intersegment coordination measures could identify age-related changes in balance of seniors compared to young adults (<i>p</i> &lt; 0.05). Moreover, balance biomarkers of senior adults exhibited a reduced sway acceleration and jerkiness in the medial-lateral direction post-rehabilitation (<i>p</i> &lt; 0.05). Although the total BBS scores increased post-rehabilitation, sway displacement and velocity did not significantly improve. We observed a significant association between pelvis-leg coordination at high sway oscillations and the total BBS scores pre- and post-rehabilitation. <b><i>Conclusion:</i></b> IMUs enable not only the characterization of underlying causes of impaired balance but also the identification of improved and yet impaired aspects of balance post-rehabilitation. Hence, IMUs allow us to characterize risk factors post-rehabilitation in elderly fallers, whereas the BBS scores only show changes in overall balance. It is crucial to objectively evaluate the effectiveness of such interventions to reduce future falls and their adverse consequences. Therefore, instrumented balance assessment is recommended since it can provide quantitative and objective measures for clinical outcome evaluations.
DOI: 10.6084/m9.figshare.19085417.v1
title: Supplementary Material for: Instrumented Functional Test for Objective Outcome Evaluation of Balance Rehabilitation in Elderly Fallers: A Clinical Study

description: <b><i>Introduction:</i></b> Observational tests, e.g., the Berg Balance Scale (BBS) are widely used for balance evaluation in the elderly fallers. However, they do not allow objective outcome evaluation of rehabilitative interventions. This study aimed to investigate, in a clinical setting, the use of inertial measurement units (IMUs) integrated into the BBS test for objective outcome evaluation of balance rehabilitation in elderly fallers compared to conventional BBS scores. <b><i>Methods:</i></b> Thirty-six elderly fallers were recruited from the in-patient population of a geriatrics Clinic. Participants performed the BBS test while wearing 3 IMUs placed on the sternum, sacrum, and tibia of the dominant leg following admission to the clinic. Subsequently, they completed a rehabilitation program for 2–4 weeks. They performed a similar test before their discharge. The physical therapist recorded the BBS scores at both sessions, and the sensor data of the 2-min quiet standing task (BBS task 2) were extracted for objective balance evaluation. Moreover, eleven young adults were recruited to perform a 2-min quiet standing test while wearing the same IMUs. Center-of-pressure (COP) and segmental center-of-mass (COM) accelerations were calculated to estimate time-domain, frequency-domain, and intersegment coordination biomarkers of balance. <b><i>Results:</i></b> COP time- and frequency-domain measures, COM acceleration time-domain measures, and intersegment coordination measures could identify age-related changes in balance of seniors compared to young adults (<i>p</i> &lt; 0.05). Moreover, balance biomarkers of senior adults exhibited a reduced sway acceleration and jerkiness in the medial-lateral direction post-rehabilitation (<i>p</i> &lt; 0.05). Although the total BBS scores increased post-rehabilitation, sway displacement and velocity did not significantly improve. We observed a significant association between pelvis-leg coordination at high sway oscillations and the total BBS scores pre- and post-rehabilitation. <b><i>Conclusion:</i></b> IMUs enable not only the characterization of underlying causes of impaired balance but also the identification of improved and yet impaired aspects of balance post-rehabilitation. Hence, IMUs allow us to characterize risk factors post-rehabilitation in elderly fallers, whereas the BBS scores only show changes in overall balance. It is crucial to objectively evaluate the effectiveness of such interventions to reduce future falls and their adverse consequences. Therefore, instrumented balance assessment is recommended since it can provide quantitative and objective measures for clinical outcome evaluations.
DOI: 10.6084/m9.figshare.16726972
title: Gls1 in Sjogren's syndrome

description: The original analyzed data of the investigation of Gls1 in Sjogren's syndrome<br>
DOI: 10.6084/m9.figshare.16726972.v1
title: Gls1 in Sjogren's syndrome

description: The original analyzed data of the investigation of Gls1 in Sjogren's syndrome<br>
DOI: 10.15151/esrf-es-661842139
title: Study of novel P and S fertilizers

description: This proposal will continue the work on novel P coated with polysulfides
DOI: 10.6084/m9.figshare.17372048
title: Supplementary Material for: The effect of various fluoride products on dentine lesions during pH-cycling

description: This study compared the effect of topically applied fluoride products on dentine lesions in an in vitro experiment. Demineralized bovine dentine specimens were treated once with either SDF solution (35,400 ppm F), NaF varnish (22,600 ppm F), TiF4 solution (9,200 ppm F), SnF2 gel (1,000 ppm F), no treatment (control) or preserved as baseline lesions. After the application and subsequent removal of the fluoride products, the specimens were subjected to pH-cycling. Calcium loss and uptake in the de- and remineralization buffers were assessed daily. Fluoride release into the buffers was analyzed on day 1, 2, 3, 5, 8 and 13. After the pH-cycling period, mineral distribution throughout the lesion depth was analyzed using transversal microradiography (TMR). X-ray energy-dispersive spectroscopy (EDS) examined the deposition of silver, titanium and tin after application of SDF, TiF4, and SnF2, respectively. Overall, calcium loss and uptake analysis in the de- and remineralization buffers revealed that the SDF product was the most effective in inhibiting lesion progression, followed by the TiF4, NaF, and SnF2 products. Fluoride analysis disclosed a steep reduction of the amount of fluoride released into de- and remineralization buffers with time. The fluoride effects on de- and remineralization continued beyond the days that fluoride was released into the buffers. TMR analysis showed significant remineralization in the outer zone of the dentine lesions for all fluoride products, with SDF giving hyper-mineralization in this zone. In the inner zone, lesions developed in all fluoride groups, with the smallest in the SDF group. EDS showed silver and titanium deposition in depth up to 85 μm and 8 μm, respectively, while no tin deposition was observed. The silver in the dentine lesions did not contribute significantly to the density of the TMR profiles in the SDF group. In conclusion, all topical fluoride products protected the dentine lesions against lesion progression, but at different degrees. SDF showed a superior effect in protection against further demineralization and enhancement of remineralization. This was probably attributed to its fluoride concentration that was the highest among the fluoride products.