cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.3979194
title: Aging norms for IADS stimulus set

description: Sound rating study: 24 younger (ages 18-30) and 24 older adults (ages 60-77) rated 45 IADS sounds from each of four emotional categories: arousing positive (14 sounds), arousing negative (8 sounds), non-arousing positive (9 sounds), and non-arousing negative (14 sounds). Order of presentation of the sounds was randomized. The ratings were made on the self-assessment manikin (Lang, 1980) which allows participants to rate each sound on its arousal, valence, and dominance (just as in Bradley & Lang, 2007). Participants indicate how the sound makes them feel by bubbling in a circle underneath the appropriate face on a gradient (e.g. smiling to frowning), which is then converted to a score out of 9 (higher scores indicate that the sound was more arousing or more pleasant) <br><br>Bradley, M. M., & Lang, P. J. (2007). The international affective digitized sounds (; IADS-2): Affective ratings of sounds and instruction manual. University of Florida, Gainesville, FL, Tech.Rep.B-3.<br>Lang, P. J. (1980). Self-assessment manikin. <i>Gainesville, FL: The Center for Research in Psychophysiology, University of Florida</i>.<br>
DOI: 10.7910/dvn/v1rjpf/iu0wmp
title: snk20161002_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.3979194.v1
title: Aging norms for IADS stimulus set

description: Sound rating study: 24 younger (ages 18-30) and 24 older adults (ages 60-77) rated 45 IADS sounds from each of four emotional categories: arousing positive (14 sounds), arousing negative (8 sounds), non-arousing positive (9 sounds), and non-arousing negative (14 sounds). Order of presentation of the sounds was randomized. The ratings were made on the self-assessment manikin (Lang, 1980) which allows participants to rate each sound on its arousal, valence, and dominance (just as in Bradley & Lang, 2007). Participants indicate how the sound makes them feel by bubbling in a circle underneath the appropriate face on a gradient (e.g. smiling to frowning), which is then converted to a score out of 9 (higher scores indicate that the sound was more arousing or more pleasant) <br><br>Bradley, M. M., & Lang, P. J. (2007). The international affective digitized sounds (; IADS-2): Affective ratings of sounds and instruction manual. University of Florida, Gainesville, FL, Tech.Rep.B-3.<br>Lang, P. J. (1980). Self-assessment manikin. <i>Gainesville, FL: The Center for Research in Psychophysiology, University of Florida</i>.<br>
DOI: 10.7910/dvn/v1rjpf/252dyj
title: snk20161003_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.3979176
title: Muscle strength and quality of life in patients with childhood cancer at early phase of primary treatment

description: Cancer- and treatment-related side effects in patients with childhood cancer may cause limitations in motor performance affecting activities of daily living (ADLs). Data focusing on long-term effects are available, but little is known with regard to the short-term perspective. Therefore, the purpose of this study was to assess muscle strength performance and quality of life (QoL) in children and adolescents with cancer at the beginning of primary treatment. Forty children and adolescents aged 5–18 years (mean: 11.39 ± 4.08 years) with different types of childhood cancer were enrolled. On average 36 ± 20.5 days after diagnosis, strength performance in 7 muscle groups was assessed by handheld dynamometry. KINDL questionnaires were completed to evaluate QoL (children's self-report and parents' report). All parameters were compared with age- and gender-matched reference values. Patients with childhood cancer showed significantly lower strength values in all muscle groups (<i>P</i> &lt; .01) compared with age- and gender-matched controls. Most affected were the lower extremities, with a −57.1% ± 10.4%, median: −59.2%, minimum: −75.4%, maximum: −41.4% percentage deviation in knee flexion from healthy peers. Children themselves and parents assessed total QoL significantly below age- and gender-matched reference values (<i>P</i> &lt; .01). Correlation between elbow flexion and self-reported QoL was detected. Broader correlations were found for the parents' report. Muscle weakness and decreased QoL in children and adolescents seem to persist already at the beginning of anticancer treatment. This underlines the need of counteracting measures, such as exercise intervention programs, starting as early as possible during the treatment process. Efforts on this topic are currently being carried out by our group.
DOI: 10.6084/m9.figshare.3979176.v1
title: Muscle strength and quality of life in patients with childhood cancer at early phase of primary treatment

description: Cancer- and treatment-related side effects in patients with childhood cancer may cause limitations in motor performance affecting activities of daily living (ADLs). Data focusing on long-term effects are available, but little is known with regard to the short-term perspective. Therefore, the purpose of this study was to assess muscle strength performance and quality of life (QoL) in children and adolescents with cancer at the beginning of primary treatment. Forty children and adolescents aged 5–18 years (mean: 11.39 ± 4.08 years) with different types of childhood cancer were enrolled. On average 36 ± 20.5 days after diagnosis, strength performance in 7 muscle groups was assessed by handheld dynamometry. KINDL questionnaires were completed to evaluate QoL (children's self-report and parents' report). All parameters were compared with age- and gender-matched reference values. Patients with childhood cancer showed significantly lower strength values in all muscle groups (<i>P</i> &lt; .01) compared with age- and gender-matched controls. Most affected were the lower extremities, with a −57.1% ± 10.4%, median: −59.2%, minimum: −75.4%, maximum: −41.4% percentage deviation in knee flexion from healthy peers. Children themselves and parents assessed total QoL significantly below age- and gender-matched reference values (<i>P</i> &lt; .01). Correlation between elbow flexion and self-reported QoL was detected. Broader correlations were found for the parents' report. Muscle weakness and decreased QoL in children and adolescents seem to persist already at the beginning of anticancer treatment. This underlines the need of counteracting measures, such as exercise intervention programs, starting as early as possible during the treatment process. Efforts on this topic are currently being carried out by our group.
DOI: 10.7910/dvn/v1rjpf/vxzajn
title: snk20150828_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.3979173
title: field sample training with animals

description: We have a group of four people, and the data was collected at two locations, Grassland and Woodlot at York University. It was modest sunlight and slightly cloudy. The wind was slightly breezing. The temperature was 20 to 22 degrees. We did belt transect of 15 metres with a tape along with the grassland. Transects we chose over grassland was randomly. Our group was divided by two, and every two person do five transects at the grassland. One person holds the timer and the other one sweeping left right direction along transect. The net was sweeping on the tip of the grassland. We count time used for sweeping, Abundance and diversity of insects collected in the sweeping net. <br>
DOI: 10.6084/m9.figshare.3979173.v1
title: field sample training with animals

description: We have a group of four people, and the data was collected at two locations, Grassland and Woodlot at York University. It was modest sunlight and slightly cloudy. The wind was slightly breezing. The temperature was 20 to 22 degrees. We did belt transect of 15 metres with a tape along with the grassland. Transects we chose over grassland was randomly. Our group was divided by two, and every two person do five transects at the grassland. One person holds the timer and the other one sweeping left right direction along transect. The net was sweeping on the tip of the grassland. We count time used for sweeping, Abundance and diversity of insects collected in the sweeping net. <br>
DOI: 10.7910/dvn/v1rjpf/0jllmh
title: snk20160302_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.3979161
title: Transcale average consensus of directed multi-vehicle networks with fixed and switching topologies

description: This paper contributes to solving a class of so-called ‘transcale average consensus’ problems for directed networks of vehicles with single-integrator dynamics. It generalises the idea of average consensus by taking into account the measurement scale of every vehicle's information state. Using the nearest neighbour-interaction rules, distributed algorithms are presented which are shown with the ability to achieve the transcale average consensus for directed networks associated with balanced graphs. Such consensus results are applicable to networks in the presence of both fixed topology and switching topologies, which are also illustrated via simulation tests. Moreover, improved algorithms and results of consensus are given for directed networks associated with unbalanced graphs.
DOI: 10.7910/dvn/v1rjpf/md8kbl
title: snk20150913_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.3979161.v1
title: Transcale average consensus of directed multi-vehicle networks with fixed and switching topologies

description: This paper contributes to solving a class of so-called ‘transcale average consensus’ problems for directed networks of vehicles with single-integrator dynamics. It generalises the idea of average consensus by taking into account the measurement scale of every vehicle's information state. Using the nearest neighbour-interaction rules, distributed algorithms are presented which are shown with the ability to achieve the transcale average consensus for directed networks associated with balanced graphs. Such consensus results are applicable to networks in the presence of both fixed topology and switching topologies, which are also illustrated via simulation tests. Moreover, improved algorithms and results of consensus are given for directed networks associated with unbalanced graphs.
DOI: 10.7910/dvn/v1rjpf/gblz5u
title: snk20150425_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.3979131
title: The 3′-untranslated region of mRNAs as a site for ribozyme cleavage-dependent processing and control in bacteria

description: Besides its primary informational role, the sequence of the messenger RNA (mRNA) including its 5′- and 3′- untranslated regions (UTRs), contains important features that are relevant for post-transcriptional and translational regulation of gene expression. In this work a number of bacterial twister motifs are characterized both <i>in vitro</i> and <i>in vivo</i>. The analysis of their genetic contexts shows that these motifs have the potential of being transcribed as part of polycistronic mRNAs, thus we suggest the involvement of bacterial twister motifs in the processing of mRNA. Our data show that the ribozyme-mediated cleavage of the bacterial 3′-UTR has major effects on gene expression. While the observed effects correlate weakly with the kinetic parameters of the ribozymes, they show dependence on motif-specific structural features and on mRNA stabilization properties of the secondary structures that remain on the 3′-UTR after ribozyme cleavage. Using these principles, novel artificial twister-based riboswitches are developed that exert their activity via ligand-dependent cleavage of the 3′-UTR and the removal of the protective intrinsic terminator. Our results provide insights into possible biological functions of these recently discovered and widespread catalytic RNA motifs and offer new tools for applications in biotechnology, synthetic biology and metabolic engineering.
DOI: 10.6084/m9.figshare.3979131.v1
title: The 3′-untranslated region of mRNAs as a site for ribozyme cleavage-dependent processing and control in bacteria

description: Besides its primary informational role, the sequence of the messenger RNA (mRNA) including its 5′- and 3′- untranslated regions (UTRs), contains important features that are relevant for post-transcriptional and translational regulation of gene expression. In this work a number of bacterial twister motifs are characterized both <i>in vitro</i> and <i>in vivo</i>. The analysis of their genetic contexts shows that these motifs have the potential of being transcribed as part of polycistronic mRNAs, thus we suggest the involvement of bacterial twister motifs in the processing of mRNA. Our data show that the ribozyme-mediated cleavage of the bacterial 3′-UTR has major effects on gene expression. While the observed effects correlate weakly with the kinetic parameters of the ribozymes, they show dependence on motif-specific structural features and on mRNA stabilization properties of the secondary structures that remain on the 3′-UTR after ribozyme cleavage. Using these principles, novel artificial twister-based riboswitches are developed that exert their activity via ligand-dependent cleavage of the 3′-UTR and the removal of the protective intrinsic terminator. Our results provide insights into possible biological functions of these recently discovered and widespread catalytic RNA motifs and offer new tools for applications in biotechnology, synthetic biology and metabolic engineering.
DOI: 10.7910/dvn/v1rjpf/hdbter
title: snk20161108_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/ll8epa
title: snk20150808_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/c6p7v5
title: snk20160827_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/2zw4sd
title: snk20150730_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/kutfvw
title: snk20150506_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.3979056
title: PRSA Code and Results

description: Code and Results for PRSA Article
DOI: 10.6084/m9.figshare.3979020
title: Fungal non-reducing polyketide synthases - Plot 2

description: This is a strip plot of fungal non-reducing polyketide synthases PT domain hits across several different environmental metagenomes.
DOI: 10.7910/dvn/v1rjpf/cgl0vq
title: snk20150313_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.3979020.v1
title: Fungal non-reducing polyketide synthases - Plot 2

description: This is a strip plot of fungal non-reducing polyketide synthases PT domain hits across several different environmental metagenomes.
DOI: 10.7910/dvn/v1rjpf/jqicvw
title: snk20151001_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.3979014
title: Student answers to a questionnaire to assess a project-based learning software design course in 14/15 and 15/16

description: Answers to the questionnaire in courses 14/15 and 15/16: scanned hand-written responses (in PDF), and CSV files with the answers to the Likert scale questions.
DOI: 10.7910/dvn/v1rjpf/f4v0e8
title: snk20150118_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/c1zkyh
title: snk20161205_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/gsgaky
title: snk20151230_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/qko06u
title: snk20150410_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/n8fgmx
title: snk20150129_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.3978894
title: Development of a combined radiation and full thickness burn injury minipig model to study the effects of uncultured adipose-derived regenerative cell therapy in wound healing

description: <b>Purpose:</b> To develop an approach that models the cutaneous healing that occurs in a patient with full thickness thermal burn injury complicated by total body radiation exposure sufficient to induce sub-lethal prodromal symptoms. An assessment of the effects of an autologous cell therapy on wound healing on thermal burn injury with concomitant radiation exposure was used to validate the utility of the model. <b>Methods:</b> Göttingen minipigs were subjected to a 1.2 Gy total body irradiation by exposure to a 6 MV X-ray linear accelerator followed by ∼10 cm<sup>2</sup> full thickness burns (pre-heated brass block with calibrated spring). Three days after injury, wounds were excised to the underlying fascia and each animal was randomized to receive treatment with autologous adipose-derived regenerative cells (ADRC) delivered by local or intravenous injection, or vehicle control. Blood counts were used to assess radiation-induced marrow suppression. All animals were followed using digital imaging to assess wound healing. Full-thickness biopsies were obtained at 7, 14, 21 and 30 days’ post-treatment. <b>Results:</b> Compared to animals receiving burn injury alone, significant transient neutropenia and thrombocytopenia were observed in irradiated subjects with average neutrophil nadir of 0.79 × 10<sup>3</sup>/μl (day 15) and platelet nadir of 60 × 10<sup>3</sup>/μl (day 12). Wound closure through a combination of contraction and epithelialization from the wound edges occurred over a period of approximately 28 days’ post excision and treatment. Re-epithelialization was accelerated in wounds treated with ADRC (mean 3.5-fold increase at 2 weeks post-treatment relative to control). This acceleration was accompanied by an average 67% increase in blood vessel density and 30% increase in matrix (collagen) deposition. Similar results were observed when ADRC were injected either directly into the wound or by intravenous administration. <b>Conclusions:</b> Although preliminary, this study provides a reproducible minipig model of thermal burn injury complicated by myelosuppressive total body irradiation that utilizes standardized procedures to evaluate novel countermeasures for potential use following attack by an improvised nuclear device.
DOI: 10.7910/dvn/v1rjpf/zmmjsp
title: snk20150526_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/zmx4hi
title: snk20160607_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.3978894.v1
title: Development of a Combined Radiation and Full Thickness Burn Injury Minipig Model to Study the Effects of Uncultured Adipose-Derived Regenerative Cell Therapy in Wound Healing

description: <b>Purpose:</b> The objective of this study was to develop an approach that models the cutaneous healing that occurs in a patient with full thickness thermal burn injury complicated by total body radiation exposure sufficient to induce sub-lethal prodromal symptoms. An assessment of the effects of an autologous cell therapy on wound healing on thermal burn injury with concomitant radiation exposure was used to validate the utility of the model. <b>Methods:</b> Göttingen minipigs were subjected to a 1.2 Gy total body irradiation by exposure to a 6 MV X-ray linear accelerator followed by ∼10 cm<sup>2</sup> full thickness burns (pre-heated brass block with calibrated spring). Three days after injury, wounds were excised to the underlying fascia and each animal was randomized to receive treatment with autologous Adipose-Derived Regenerative Cells (ADRCs) delivered by local or intravenous injection, or vehicle control. Blood counts were used to assess radiation-induced marrow suppression. All animals were followed using digital imaging to assess wound healing. Full-thickness biopsies were obtained at 7, 14, 21 and 30 days post-treatment. <b>Results:</b> Compared to animals receiving burn injury alone, significant transient neutropenia and thrombocytopenia were observed in irradiated subjects with average neutrophil nadir of 0.79x10<sup>3</sup>/μl (day 15) and platelet nadir of 60x10<sup>3</sup>/μl (day 12). Wound closure through a combination of contraction and epithelialization from the wound edges occurred over a period of approximately 28 days post excision and treatment. Re-epithelialization was accelerated in wounds treated with ADRCs (mean 3.5-fold increase at two weeks post- treatment relative to control). This acceleration was accompanied by an average 67% increase in blood vessel density and 30% increase in matrix (collagen) deposition. Similar results were observed when ADRCs were injected either directly into the wound or by intravenous administration. <b>Conclusions:</b> Although preliminary, this study provides a reproducible minipig model of thermal burn injury complicated by myelosuppressive total body irradiation that utilizes standardized procedures to evaluate novel countermeasures for potential use following attack by an improvised nuclear device.
DOI: 10.6084/m9.figshare.3978783
title: Feeding trials of bromeliad invertebrates

description: To test whether related predators eat similar prey, we fed prey to predators in laboratory feeding trials. We conducted 314 feeding trials of 10 predator taxa and 14 prey taxa between March and April 2011. We performed as many feeding trials as possible, however many combinations between rare taxa are still missing. We tested 56 pairwise combinations. Most trials were replicated at least five times, but the number of replicates ranged from 1 to 11. To conduct the trials, we placed predators together with prey in a 50ml vial, with a stick for substrate. The only exception was the tabanid larvae, which we placed between two vertical surfaces to imitate the narrow space found in bromeliad leaf axils (their preferred microhabitat, necessary for successful feeding). Generally our trials contained a single predator and a single prey individual, except in the case of very small prey (_Elpidium_ sp.) or predators (_Monopelopia_ sp.) in which case we increased the density of the small taxon to five. We recorded whether prey was consumed after 24 hours. <br><br>All tests were performed at the Parque Estadual da Ilha do Cardoso, in São Paulo State, Brazil (25° 03' S, 47° 53' W)<br>
DOI: 10.7910/dvn/v1rjpf/mafnjh
title: snk20150905_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.3978783.v1
title: Feeding trials of bromeliad invertebrates

description: To test whether related predators eat similar prey, we fed prey to predators in laboratory feeding trials. We conducted 314 feeding trials of 10 predator taxa and 14 prey taxa between March and April 2011. We performed as many feeding trials as possible, however many combinations between rare taxa are still missing. We tested 56 pairwise combinations. Most trials were replicated at least five times, but the number of replicates ranged from 1 to 11. To conduct the trials, we placed predators together with prey in a 50ml vial, with a stick for substrate. The only exception was the tabanid larvae, which we placed between two vertical surfaces to imitate the narrow space found in bromeliad leaf axils (their preferred microhabitat, necessary for successful feeding). Generally our trials contained a single predator and a single prey individual, except in the case of very small prey (_Elpidium_ sp.) or predators (_Monopelopia_ sp.) in which case we increased the density of the small taxon to five. We recorded whether prey was consumed after 24 hours. <br><br>All tests were performed at the Parque Estadual da Ilha do Cardoso, in São Paulo State, Brazil (25° 03' S, 47° 53' W)<br>
DOI: 10.7910/dvn/v1rjpf/mubjiu
title: snk20160821_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/ndfu2k
title: snk20150413_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/g12ixw
title: snk20161119_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/ypmhyb
title: snk20160309_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/jfhijc
title: snk20150330_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/u1zrzi
title: snk20160716_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/p2tb6z
title: snk20160711_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/bjbnf1
title: snk20161004_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/q6oopb
title: snk20150329_03.txt.gz

description: :unav