cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.22340443
title: Supplementary Material for: Air versus Gas Tamponade for Primary Rhegmatogenous Retinal Detachment: A Systematic Review and Meta-analysis

description: Background: Air tamponade’s effectiveness in treatment of rhegmatogenous retinal detachment (RRD) remains unclear. Objective: We aimed to review the surgical outcomes between air and gas tamponade after vitrectomy for RRD. Method: PubMed, Cochrane Library, EMBASE, and Web of Science were reviewed. The study protocol was registered in the International Prospective Register of Systematic Reviews (PROSPERO CRD42022342284). The primary outcome was the primary anatomical success after vitrectomy. The secondary outcome was the prevalence of postoperative ocular hypertension. Certainty of evidence was evaluated using the Grading of Recommendations Assessment, Development, and Evaluation system. Results: Ten studies involving 2677 eyes were included. One study was randomized, and the others were non-randomized. The primary anatomical success after vitrectomy was not significantly different between the air and gas groups (odds ratio [OR], 1.00; 95% confidence interval [CI], 0.68–1.48). The risk of ocular hypertension was significantly lower in the air group (OR, 0.14; 95% CI, 0.09–0.24). The certainty of evidence regarding air tamponade having an comparable anatomical outcome and lower frequency of postoperative ocular hypertension in treatment of RRD were low. Discussion: The current evidence base for tamponade selection in treatment of RRD has several major limitations. Further appropriately designed studies are needed to guide tamponade selection.
DOI: 10.6084/m9.figshare.22340905
title: Supplementary Material for: Case Report Successful preoperative QUAD SHOT for bulky parotid carcinoma: Potential preopetative ultra-hypofractionated radiotherapy for conversion surgery

description: QUAD SHOT is an ultra-hypofractionated radiotherapy (RT) technique that prescribes 14.0–14.8 Gy over 2 days. Although this technique has already gained some status as an effective palliative treatment for inoperable head and neck cancer (HNC), its application in other situations has not been given much consideration. Herein, we report a case of a 62-year-old woman who received preoperative QUAD SHOT therapy for poorly differentiated parotid carcinoma. In this case, after two courses of QUAD SHOT plus a standard chemotherapy regimen with pembrolizumab, the patient’s inoperable bulky tumor shrank dramatically and became operable. Best of all, while adequate therapeutic effects were achieved, the patient’s time commitment and physical exertion were limited. RT during this period consisted of only eight fractions over four days. According to previous reports, the response rate for QUAD SHOT is sufficiently high, and the rate of serious adverse events is quite low. This case asks the question of whether the indications for QUAD SHOT irradiation can be expanded as one of the preoperative interventions undertaken by HNC surgeons to achieve conversion surgery.
DOI: 10.6084/m9.figshare.22348090
title: Supplementary Material for: Pembrolizumab induced sclerosing cholangitis, why you need a liver biopsy

description: The advent of checkpoint inhibitor immunotherapy has rapidly changed the landscape of the management of cancers. However, its use has also been associated with the rise of immunotherapy related adverse effects (irAEs). There has been an emergence in recent years of sclerosing cholangitis as a mimic of the classical autoimmune hepatitis irAE. We present a case of a 59-year-old female who received pembrolizumab for stage IV lung adenocarcinoma and developed an immune checkpoint inhibitor (ICI) related sclerosing cholangitis diagnosed on radiological and histopathological grounds. This patient was successfully treated with prednisone, azathioprine and ursodeoxycholic acid. Clinicians should be aware that immune checkpoint inhibitor sclerosing cholangitis is a rare hepatic complication of immune checkpoint inhibitors. The workup for immune checkpoint inhibitor associated mixed liver function test derangement that is steroid resistant should include a magnetic resonance cholangiopancreatography to investigate for changes of sclerosing cholangitis and a liver biopsy if the magnetic resonance cholangiopancreatography is non diagnostic.
DOI: 10.6084/m9.figshare.22566982
title: Supplementary Material for: Generalized pustular psoriasis flare-up after both doses of BBIBP-CorV vaccination in a patient under adalimumab treatment: a case report

description: Generalized pustular psoriasis is a possibly serious condition that can be triggered by various factors. Previous studies show a slight likelihood of disease exacerbation subsequent to COVID-19 vaccination. Here, we present the first (to the best of our knowledge) case of pustular psoriasis flare after each one of the two shots of the BBIBP-CorV (Sinopharm) vaccine despite adalimumab treatment.
DOI: 10.6084/m9.figshare.22619989
title: Supplementary Material for: Digital Gangrene and Antiphospholipid Syndrome in a Retinoblastoma Patient with Chromosome 13q Deletion: A Case Report

description: A 19-month-old girl with Cornelia de Lange-like dysmorphic features presented with left eye leukocoria. She was diagnosed with 13q deletion retinoblastoma grade 4 with high-risk features and bone marrow involvement. She underwent enucleation, and the first-course of intravenous chemotherapy was initiated. On day 10 after the first chemotherapy dose, she developed digital gangrene of her left hand. She was diagnosed with acute artery occlusion and limb ischemia. Thrombophilia work-up revealed antiphospholipid antibodies and paraneoplastic syndrome is another possible cause of digital gangrene. The patient’s left thumb and index finger were amputated. After one month of hospitalization, she was discharged. Before the second course of chemotherapy, the patient died of systemic metastatic retinoblastoma with respiratory failure due to pneumonia. Our postulation of the mechanism for digital gangrene was the combination of chemotherapy, paraneoplastic syndrome, and antiphospholipid syndrome. Digital gangrene could be a poor prognostic indicator in patients with retinoblastoma.
DOI: 10.6084/m9.figshare.22672582
title: Supplementary Material for: The efficacy and safety of air tamponade in the repair of rhegmatogenous retinal detachment: a systematic review and meta-analysis.

description: Background: Rhegmatogenous retinal detachment (RRD) repair by pars plana vitrectomy (PPV) combined air tamponade has many advantages compared with PPV combined gas tamponade. However, there are controversial outcomes in RRD cases involving the lower quadrants. Objective: This study aimed to evaluate the efficacy and safety of PPV combined air tamponade in patients with RRD compared with PPV combined gas tamponade and whether it could be a safe alternative to PPV combined gas tamponade. Methods: The PubMed, Embase, and Cochrane Library databases published until September 2022 were comprehensively searched for studies that compared PPV combined with air tamponade and gas tamponade in patients with RRD. The rate of primary treatment success, best-corrected visual acuity (BCVA), and postoperative complications were extracted from the final eligible studies. The mean difference (MD) and risk ratio (RR) were calculated for continuous and dichotomous variables, respectively, with 95% confidence intervals (CIs). Results: A total of 8 studies with 668 eyes in the air tamponade group and 944 in the gas tamponade group were included. There was no significant difference in the rate of primary treatment success between the air tamponade group and the gas tamponade group (RR = 1.00, P = 0.79). In addition, the subgroup analysis suggested that whether retinal breaks were located above or below, there was no significant difference in either rate of primary treatment success (RR = 0.99, P = 0.89; RR = 1.02, P = 0.45). There was no significant difference in mean BCVA 3 months after surgery (MD = -0.02, P = 0.50). For postoperative complications, mean postoperative IOP was lower in the air tamponade at one day (MD = -4.24, P &lt; 0.001), and there was no significant difference between the two groups at 7 days (MD = -0.45, P = 0.71), one month (MD = -0.69, P = 0.33), and 3 months (MD = 0.69, P = 0.35) after surgery. The rate of epiretinal membrane (ERM) development was lower in the air tamponade group (RR = 0.48, P = 0.04). Conclusions: For patients with uncomplicated RRD, PPV combined air tamponade is a feasible and safe alternative to PPV combined gas tamponade, regardless of the position of retinal breaks, with a similar primary treatment success rate, postoperative BCVA, and fewer postoperative complications.
DOI: 10.6084/m9.figshare.22699885
title: Supplementary Material for: Differentiating between laryngopharyngeal dysesthesia and hypersensitivity reactions to oxaliplatin and addressing dyspnea: Two case reports

description: Oxaliplatin is a key drug for colorectal cancer and causes peripheral neuropathy. Oxaliplatin-induced laryngopharyngeal dysesthesia is an acute peripheral neuropathy similar to a hypersensitivity reaction. Hypersensitivity reactions to oxaliplatin do not require immediate discontinuation, but re-challenge and desensitization therapy can be very burdensome for patients. We encountered two cases in which laryngopharyngeal dysesthesia could be differentiated from hypersensitivity reactions to oxaliplatin, and treatment could continue. The first case was that of a 58-year-old woman who developed dyspnea during the first course of combination therapy with capecitabine and oxaliplatin as the primary treatment for advanced rectal cancer. After laryngopharyngeal dysesthesia was differentiated from hypersensitivity reaction based on these typical symptoms, she was considered to have grade 3 (Common Terminology Criteria for Adverse Events (CTCAE) ver.5) laryngopharyngeal dysesthesia. The second course of oxaliplatin was extended from two to four hours, but symptoms recurred. The third course was performed with a reduced dose of oxaliplatin from 130 mg/m2 to 100 mg/m2, and the patient could complete the treatment without symptom recurrence. The second case involved a 76-year-old woman who developed grade 3 laryngopharyngeal dysesthesia during the first course of combination therapy with capecitabine and oxaliplatin as the primary treatment for localized colon cancer. Based on the experience of the first case, we reduced the oxaliplatin dose from 130 mg/m2 to 100 mg/m2 for the second course, and the patient completed the treatment without symptoms. This dose reduction was effective for grade 3 laryngopharyngeal dysesthesia caused by oxaliplatin without reducing therapeutic efficacy.
DOI: 10.5281/zenodo.7738094
title: Hourly Air Temperature Datasets from city of Novi Sad - NSUNET system

description: This dataset captures hourly air temperature data from 12 urban sites in Novi Sad (Serbia) over a period of 2 years covering 2016 and 2017 (measurement time is in UTC). There are 2 datasets in the collection: one dataset provides details about the 12 sites at which the temperature sensors are placed (Table 1, excel file), while the second file contains air temperature data at the 12 locations (.csv file). In all, the second dataset contains 17,544 instances of air temperature data. The temperature data has been cleaned and gap-filled so there are 24 measures at each site for each day. There are multiple potential uses for this data. It can provide insights when trying to understand intra-urban and inter-urban research, urban climate modeling on local or micro scales, heat-related public health investigations and urban environment inquiries. It can also be used in machine learning experiments, for example, to test the accuracy of classification algorithms or to build and validate spatio-temporal machine learning functions, either for classification purposes or for gap filling.
description: Quality Control methodology guideline, 2023. Available at: https://drive.google.com/drive/folders/1tvDpMMvN10JQni4o6X3SIql5bJ5yls3r?usp=sharing
description: {"references": ["I. \u0160e\u0107erov, S. Savi\u0107, D. Milo\u0161evi\u0107, D. Arsenovi\u0107, D. Dolinaj, S. Popov, 2019. Progressing urban climate research using a high-density monitoring network system. Environ. Monit. Assess. 191, 89. https://doi.org/10.1007/s10661-019-7210-0"]}
DOI: 10.5291/ill-data.9-13-858
title: Investigating structural organization of cell-penetrating peptides and insulin complexes
DOI: 10.6084/m9.figshare.22308628
title: Supplementary Material for: The consistency between registered acupuncture-moxibustion clinical studies and their published studies and update status of registered information

description: Background: Few studies have analyzed the consistency between registered acupuncture-moxibustion clinical studies and their published research results as well as their update status of registered information. Methods: We searched for acupuncture-moxibustion clinical studies that were registered at the World Health Organization International Clinical Trials Registry Platform between 2013 and 2015 and collected data regarding their characteristics and update status. Published results of these registered studies were identified and compared with registered information. Results: A total of 425 registered acupuncture-moxibustion clinical studies were included; 379 (89.2%) of them were interventional studies, and the remaining 46 (10.8%) were observational studies. Forty-six studies (10.8%) were found to have published results, and 51 published articles were identified. Overall, 73.2% (311) of registered studies did not update the research status in time; 46.6% (198) stopped updating before recruiting; 21.6% (92) stopped updating after recruiting; and 4.9% (21) stopped updating after completion. Regarding the 46 studies with published results, 29 (63.0%) were considered to be affected by reporting bias. These reporting biases predominantly involved the omission of some predefined outcomes or endpoints (16 studies), contradictions regarding descriptions of sample sizes (9 studies), discrepancies in treatment measurements or group distribution (7 studies), and inconsistent treatment durations (4 studies). When compared with other studies, significant and various reporting biases could also be commonly found in fields other than acupuncture-moxibustion. Conclusions: There were many discrepancies between registered information and published reports on acupuncture-moxibustion, which could also be commonly observed in other fields. Moreover, a large proportion of registered studies did not update their research status in time. Efforts should be made to improve the reporting quality and timely updates.
DOI: 10.6084/m9.figshare.23530008
title: Supplementary Material for: Diffuse Infiltrating Retinoblastoma with Anterior Chamber Involvement: Conservative Management and Identification of <i>RB1</i> Alterations in Aqueous Humor

description: <b><i>Introduction:</i></b> The aim of the study was to describe the successful conservative management of diffuse infiltrating retinoblastoma (DIR). Identification of <i>RB1</i> pathogenic variant was done after cell-free DNA (cfDNA) analysis in aqueous humor. <b><i>Case presentation:</i></b> Herein, we report 2 patients with unilateral, non-familial DIR with anterior and posterior involvement. Both patients underwent liquid biopsy for tumor cfDNA analysis in aqueous humor. Treatment consisted of a combination of systemic and intra-arterial chemotherapy, with consecutive intracameral and intravitreal injections of melphalan. One patient also required iodine-125 brachytherapy. In both cases, tumor cfDNA analysis revealed biallelic somatic alterations of the <i>RB1</i> gene. These alterations were not found in germline DNA. Both patients retained their eyes and had a useful vision after a follow-up of 2 years. <b><i>Conclusion:</i></b> In selected cases, conservative management of DIR is safe and effective. Tumor cfDNA analysis in aqueous humor is an effective technique to disclose <i>RB1</i> somatic alterations that guide the germline molecular explorations and improve genetic counseling after conservative treatment.
DOI: 10.25493/kjqn-am0
title: Whole-brain parcellation of the Julich-Brain Cytoarchitectonic Atlas (v2.6)

description: This dataset contains the whole-brain parcellation of the Julich-Brain Cytoarchitectonic Atlas in the MNI ICBM 152 2009c nonlinear asymmetric reference space ([Evans et al., 2012](https://www.sciencedirect.com/science/article/pii/S1053811912000419?via%3Dihub)). The parcellation is derived from the individual probability maps (PMs) of the cytoarchitectonic regions released in the Julich-Brain Cytoarchitectonic Atlas, that are further combined into a Maximum Probability Map (MPM). The MPM is calculated by considering for each voxel the probability of all cytoarchitectonic areas released in the atlas, and determining the most probable assignment ([Eickhoff 2005](https://www.sciencedirect.com/science/article/pii/S105381190400792X?via%3Dihub)). Gap maps complement cortical maps to achieve full cortical coverage.
DOI: 10.25835/n3l98dkt
title: MW-source-component-list

description: Component list for the microwave source described in “Dynamical low-noise microwave source for cold atom experiments” by Meyer-Hoppe et al.
DOI: 10.6084/m9.figshare.21915042
title: Supplementary Material for: Efficacy of Local Treatment in Lymph Node Metastasis from Hepatocellular Carcinoma

description: Introduction: We aimed to investigate the significance of lymph node metastasis from hepatocellular carcinoma and the efficacy of local treatment. Methods : We included patients diagnosed with hepatocellular carcinoma with lymph node metastasis. The pattern of lymph node metastasis was evaluated based on imaging examinations and stratified by three locations: regional (group A), beyond regional intra-abdomen (group B), and extra-abdomen (group C) lymph node metastasis. Results: Among 14474 patients, 852 (5.8%) were identified as having lymph node metastasis. Regarding the location of presentation, group A showed the highest incidence, followed by groups B and C. The 1-year overall survival of patients was 31.7%. The survival significantly differed according to the location of lymph node metastasis. The 1-year overall survival rates were 39.8%, 25.5%, and 22.2% in groups A, B, and C, respectively. All patients underwent systemic treatment, with others receiving additional local treatment. Local treatment yielded superior overall survival compared with no local treatment. After propensity score matching, local treatment was associated with improved survival. Additionally, patients were stratified based on disease status at the time of diagnosis of lymph node metastasis: lymph node alone and combined extra-nodal metastasis. The survival benefits of local treatment were observed in both groups. Conclusions: Our findings demonstrated the clinical significance of lymph node metastasis from hepatocellular carcinoma, which was well discriminated according to location, favoring regional metastasis. In patients with hepatocellular carcinoma presenting lymph node metastasis, active application of local treatment for lymph node metastasis can improve oncologic outcomes.
DOI: 10.6084/m9.figshare.21929610
title: Supplementary Material for: IMPACT OF THE COVID-19 PANDEMIC ON CERVICAL CANCER SCREENING IN SÃO PAULO STATE, BRAZIL

description: INTRODUCTION: The early identification of precursor lesions followed by appropriate treatment prevents development of cervical cancer and its consequences OBJECTIVE: The present study evaluated the influence of the Covid-19 pandemic on cervical cancer screening by comparing the quantity of tests to detect cervical cellular changes performed in Sao Paulo state in 2019, prior to the detection of SARS-CoV-2 in Brazil, to the first (2020) and second (2021) years following its appearance. MATERIALS AND METHODS: Data from Fundação Oncocentro de São Paulo (FOSP), the agency that analyses approximately 220,000 Pap tests annually, was reviewed. RESULTS: A median of 1835 Papanicolaou (Pap) tests were performed in 55 municipalities in 2019. This was reduced to 815 tests in 2020, a 56% decrease (p = 0.0026). In 2021, the median number was 1745, a 53% increase over 2020 levels (p = 0.0233). The 26 municipalities with &gt;1000 tests in 2020 had a median reduction from 4433 in 2019 to 2580 in 2020 (p = 0. 0046). The 29 municipalities with &lt;1000 tests had a median reduction from 951 in 2019 to 554 in 2020 (p &lt; 0.0001). There was a 44% reduction in the number of follow-up cytological evaluations from 2019 to 2020, followed by a 30% increase the following year. However, the percentage of women with a normal finding or with any abnormality remained unchanged. The findings from a histological evaluation of women in Sao Paulo city indicated that the percent of cases positive for CIN-1 (p&lt;0.0410) and CIN-3 (p&lt;0.0012) increased in 2020 and 2021 as compared to 2019 levels. CONCLUSION: A reduction in testing for cervical cancer in the first year of the Covid-19 pandemic, accompanied by an elevated incidence of precancerous lesions in each of the first two years following its initiation, may portend a subsequent increased occurrence of cervical cancer in Brazil.
DOI: 10.6084/m9.figshare.21931290
title: Supplementary Material for: Comparative Efficacy of Subthreshold Micropulse Laser Photocoagulation vs. Conventional Laser Photocoagulation for Diabetic Macular Edema: A Meta-analysis

description: Background Laser photocoagulation is an effective procedure for the treatment of diabetic macular edema (DME). However, the beneficial effects of conventional laser photocoagulation (CLP) are accompanied by the destruction of retinal photoreceptors. Therefore, subthreshold micropulse laser photocoagulation (SMLP) was proposed for DME. Objectives This meta-analysis study was performed to evaluate the efficacy and safety of SMLP compared with CLP for the management of DME. Methods The PubMed, Embase, Web of Science, Cochrane, SinoMed, ClinicalTrials.gov, Wanfang and China National Knowledge Infrastructure (CNKI) databases, published until Dec 2021, were searched to identify studies evaluating the clinical outcomes of SMLP for DME. Results 8 randomized controlled trials (RCTs) were selected for this meta-analysis involving a total of 546 eyes (275 eyes in SMLP group and 271 eyes in CLP group). SMLP of different wavelengths (577nm and 810nm) and duty cycles (5% and 15%) were applied. The pooled outcomes showed that SMLP group, especially 577nm and 810nm 15% duty cycle parameter settings, had a statistically significant higher efficacy than CLP group in terms of BCVA(MD = -0.02, 95% CI: -0.03 to -0.01, P&lt;0.01; MD = -0.09, 95% CI: -0.09 to -0.09, P&lt;0.01) and showed more significant advantages than CLP group in resolving macular edema assessed by reduction of CMT (MD = -32.87, 95% CI: -37.61 to -28.13, P&lt;0.01; MD = -8.01, 95% CI: -9.06 to -6.96, P&lt;0.01), whereas the efficacy of 577nm and 810nm 5% duty cycle SMLP subgroups remained numerically superior to CLP group, but non-significantly (P&gt;0.05); In the field of CS, SMLP group (no matter parameter settings) resulted in better preservation of CS compared to CLP group (MD = 1.96, 95% CI: 1.47 to 2.46, P&lt;0.01). Conclusions Compared with CLP, SMLP may get superior efficacy and safety on improvement of BCVA, reduction of CMT and preservation of CS. In clinical, SMLP can be considered as a safe and effective therapy in the management of DME.