cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.7284/135120
title: Expendable Probe data collected during research cruise SKQ201912S using a Sippican MK21 instrument system onboard the platform RV Sikuliaq

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7244300
title: The relationship between topical anti-glaucoma medications and the development of lacrimal drainage system obstruction

description: ABSTRACT Purpose: To evaluate whether any topical anti-glaucoma medications increase the risk of lacrimal drainage system obstruction or whether the presence of preservatives alone is sufficient to generate obstruction. Methods: This nested case-control study compared a group of patients with lacrimal duct obstruction who received topical anti-glaucoma medications to a control group of patients without obstruction. Results: The medical records of 255 patients with glaucoma who consulted the Oculoplastic Section with complaints of watery eyes were reviewed. Among these patients, 59 exhibited lacrimal drainage obstruction. Ninety-four percent of patients with lacrimal drainage obstruction used beta-blockers, and 41% used prostaglandin analogs. A logistic regression model was used to adjust for age, sex, and the use of other medications. No significant differences were observed regarding the topical anti-glaucoma medications used between groups. Conclusion: No single topical anti-glaucoma medication demonstrated a stronger association with the development of lacrimal duct obstruction.
DOI: 10.6084/m9.figshare.7244297
title: The β-blocker carvedilol and the benznidazole modulate the cardiac immune response in the acute infection induced by Colombian strain of the Trypanosoma cruzi

description: BACKGROUND The infection led by Trypanosoma cruzi persists in mammalian tissues causing an inflammatory imbalance. Carvedilol (Cv), a non-selective beta blocker drug indicated to treat heart failure and antihypertensive has shown to promote antioxidant and immunomodulatory properties which might improve the inflammation induced by T. cruzi. OBJECTIVES Evaluate the role of Cv on the inflammatory response of C57BL/6 mice acutely infected with the Colombian strain of T. cruzi. METHODS Animals were infected with the Colombian strain of T. cruzi and treated with Cv (25 mg/kg/day), benznidazole (Bz) (100 mg/kg/day) or their combination. On the 28th day of infection and 23 days of treatment, the euthanasia occurred, and the heart preserved for histopathological, oxidative stress (SOD, catalase, TBARs, carbonylated proteins) and plasma (CCL2, CCL5, TNF, IL-10) analyses. Parasitaemia and survival were assessed along the infection. FINDINGS Cv decreased TBARs, but increased the mortality rate, the parasitaemia and the levels of CCL2, CCL5, catalase and the inflammatory infiltrate in the cardiac tissue. Bz led the reduction of the inflammatory infiltrate and circulating levels of oxidative stress and inflammatory mediators in the infected mice. MAIN CONCLUSIONS Our data suggest that Cv, in this experimental model using the Colombian strain of T. cruzi, caused damage to the host.
DOI: 10.6084/m9.figshare.7244300.v1
title: The relationship between topical anti-glaucoma medications and the development of lacrimal drainage system obstruction

description: ABSTRACT Purpose: To evaluate whether any topical anti-glaucoma medications increase the risk of lacrimal drainage system obstruction or whether the presence of preservatives alone is sufficient to generate obstruction. Methods: This nested case-control study compared a group of patients with lacrimal duct obstruction who received topical anti-glaucoma medications to a control group of patients without obstruction. Results: The medical records of 255 patients with glaucoma who consulted the Oculoplastic Section with complaints of watery eyes were reviewed. Among these patients, 59 exhibited lacrimal drainage obstruction. Ninety-four percent of patients with lacrimal drainage obstruction used beta-blockers, and 41% used prostaglandin analogs. A logistic regression model was used to adjust for age, sex, and the use of other medications. No significant differences were observed regarding the topical anti-glaucoma medications used between groups. Conclusion: No single topical anti-glaucoma medication demonstrated a stronger association with the development of lacrimal duct obstruction.
DOI: 10.7284/135122
title: Flowmeter data collected during research cruise SKQ201912S using a Krohne Optiflux 5000 instrument system onboard the platform RV Sikuliaq

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7244297.v1
title: The β-blocker carvedilol and the benznidazole modulate the cardiac immune response in the acute infection induced by Colombian strain of the Trypanosoma cruzi

description: BACKGROUND The infection led by Trypanosoma cruzi persists in mammalian tissues causing an inflammatory imbalance. Carvedilol (Cv), a non-selective beta blocker drug indicated to treat heart failure and antihypertensive has shown to promote antioxidant and immunomodulatory properties which might improve the inflammation induced by T. cruzi. OBJECTIVES Evaluate the role of Cv on the inflammatory response of C57BL/6 mice acutely infected with the Colombian strain of T. cruzi. METHODS Animals were infected with the Colombian strain of T. cruzi and treated with Cv (25 mg/kg/day), benznidazole (Bz) (100 mg/kg/day) or their combination. On the 28th day of infection and 23 days of treatment, the euthanasia occurred, and the heart preserved for histopathological, oxidative stress (SOD, catalase, TBARs, carbonylated proteins) and plasma (CCL2, CCL5, TNF, IL-10) analyses. Parasitaemia and survival were assessed along the infection. FINDINGS Cv decreased TBARs, but increased the mortality rate, the parasitaemia and the levels of CCL2, CCL5, catalase and the inflammatory infiltrate in the cardiac tissue. Bz led the reduction of the inflammatory infiltrate and circulating levels of oxidative stress and inflammatory mediators in the infected mice. MAIN CONCLUSIONS Our data suggest that Cv, in this experimental model using the Colombian strain of T. cruzi, caused damage to the host.
DOI: 10.6084/m9.figshare.7244291
title: Silicate fertilization potentiates the nodule formation and symbiotic nitrogen fixation in soybean1

description: ABSTRACT The application of silicon (Si) to the soil can increase the grain yield of the soybean crop by improving the nitrogen biological fixation, due to its beneficial effect on the Bradyrhizobium-soybean symbiosis. This study aimed to investigate the effect of fertilization with calcium and magnesium silicate on plant growth, root nodulation and nitrogen (N) uptake, in two soybean cultivars [BRS 1074 IPRO (transgenic) and BRS-MG 800A (conventional)], under greenhouse conditions. The application of silicate significantly increased the number of root nodules only for the BRS-MG 800A, while the positive effects of the silicate addition on nodule size, chlorophyll level and leaf N concentration were observed in both cultivars. The soybean cultivars show distinct responses to the silicate application, with respect to growth and dry matter yield, being the BRS 1074 IPRO more responsive than the BRS-MG 800A. Therefore, Si may induce the formation of root nodules in soybean plants and lead to significant increases in the nitrogen biological fixation and plant growth. These results highlight that Si is not only involved in the improvement of plant growth, but it can be also considered a crucial element to improve the symbiotic performance of soybean plants. However, the physiological basis of how and where silicate exerts its influence on nodulation and nitrogen biological fixation still remains unknown.
DOI: 10.7284/135123
title: Fluorometer data collected during research cruise SKQ201912S using a Turner Cyclops-7 instrument system onboard the platform RV Sikuliaq

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7244288
title: Vehicular emissions estimate in the Fortaleza, Ceará, Brazil, metropolitan region in 2010

description: ABSTRACT In Brazil and worldwide, the passenger and cargo transportation sectors have decisively been responsible for the increased emissions of air pollutants, which cause serious damages for the environment and human health, as well. Thus, many studies have been carried out to model and simulate pollutant emissions through methodologies and/or specific tools. The vehicle fleet in the state of Ceará has increased by 169% over the last 10 years and, until now, the amount of pollutants released from circulating fleet of the Fortaleza Metropolitan Region (FMR) is unknown. In this context, vehicular exhaust emissions for the FMR were estimated for the year 2010. Emission estimates of carbon monoxide (CO), non-methane hydrocarbons (NMHC), nitrogen oxides (NOx), particulate matter (PM), and aldehydes (RCHO) were performed through the bottom-up methodology. In general, it was observed that motorcycles emitted high amounts of pollutants, mainly CO, NOx and MP, due to the large number of vehicles in the region. Otto cycle vehicles accounted for more than 90% of CO, NMHC and RCHO total emissions, while Diesel cycle vehicles emitted more than 85% of NOx and PM total emissions.
DOI: 10.6084/m9.figshare.7244291.v1
title: Silicate fertilization potentiates the nodule formation and symbiotic nitrogen fixation in soybean1

description: ABSTRACT The application of silicon (Si) to the soil can increase the grain yield of the soybean crop by improving the nitrogen biological fixation, due to its beneficial effect on the Bradyrhizobium-soybean symbiosis. This study aimed to investigate the effect of fertilization with calcium and magnesium silicate on plant growth, root nodulation and nitrogen (N) uptake, in two soybean cultivars [BRS 1074 IPRO (transgenic) and BRS-MG 800A (conventional)], under greenhouse conditions. The application of silicate significantly increased the number of root nodules only for the BRS-MG 800A, while the positive effects of the silicate addition on nodule size, chlorophyll level and leaf N concentration were observed in both cultivars. The soybean cultivars show distinct responses to the silicate application, with respect to growth and dry matter yield, being the BRS 1074 IPRO more responsive than the BRS-MG 800A. Therefore, Si may induce the formation of root nodules in soybean plants and lead to significant increases in the nitrogen biological fixation and plant growth. These results highlight that Si is not only involved in the improvement of plant growth, but it can be also considered a crucial element to improve the symbiotic performance of soybean plants. However, the physiological basis of how and where silicate exerts its influence on nodulation and nitrogen biological fixation still remains unknown.
DOI: 10.6084/m9.figshare.7244288.v1
title: Vehicular emissions estimate in the Fortaleza, Ceará, Brazil, metropolitan region in 2010

description: ABSTRACT In Brazil and worldwide, the passenger and cargo transportation sectors have decisively been responsible for the increased emissions of air pollutants, which cause serious damages for the environment and human health, as well. Thus, many studies have been carried out to model and simulate pollutant emissions through methodologies and/or specific tools. The vehicle fleet in the state of Ceará has increased by 169% over the last 10 years and, until now, the amount of pollutants released from circulating fleet of the Fortaleza Metropolitan Region (FMR) is unknown. In this context, vehicular exhaust emissions for the FMR were estimated for the year 2010. Emission estimates of carbon monoxide (CO), non-methane hydrocarbons (NMHC), nitrogen oxides (NOx), particulate matter (PM), and aldehydes (RCHO) were performed through the bottom-up methodology. In general, it was observed that motorcycles emitted high amounts of pollutants, mainly CO, NOx and MP, due to the large number of vehicles in the region. Otto cycle vehicles accounted for more than 90% of CO, NMHC and RCHO total emissions, while Diesel cycle vehicles emitted more than 85% of NOx and PM total emissions.
DOI: 10.7284/135124
title: GNSS (Global Navigation Satellite System) data collected during research cruise SKQ201912S using a C&C C-Nav 3050 instrument system onboard the platform RV Sikuliaq

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7244276
title: 4-Phenyl-1,3-thiazole-2-amines as scaffolds for new antileishmanial agents

description: Abstract Background: There is still a need for new alternatives in pharmacological therapy for neglected diseases, as the drugs available show high toxicity and parenteral administration. That is the case for the treatment of leishmaniasis, particularly to the cutaneous clinical form of the disease. In this study, we present the synthesis and biological screening of eight 4-phenyl-1,3-thiazol-2-amines assayed against Leishmania amazonensis. Herein we propose that these compounds are good starting points for the search of new antileishmanial drugs by demonstrating some of the structural aspects which could interfere with the observed activity, as well as suggesting potential macromolecular targets. Methods: The compounds were easily synthesized by the methodology of Hantzsch and Weber, had their purities determined by Gas Chromatography-Mass spectrometry and assayed against the promastigote forms of Leishmania amazonensis as well as against two white cell lines (L929 and THP-1) and the monkey's kidney Vero cells. PrestoBlue® and MTT viability assays were the methodologies applied to measure the antileishmanial and cytotoxic activities, respectively. A molecular modeling target fishing study was performed aiming to propose potential macromolecular targets which could explain the observed biological behavior. Results: Four out of the eight compounds tested exhibited important anti-promastigote activity associated with good selectivity indexes when considering Vero cells. For the most promising compound, compound 6, IC50 against promastigotes was 20.78 while SI was 5.69. Compounds 3 (IC50: 46.63 μM; SI: 26.11) and 4 (IC50: 53.12 μM; SI: 4.80) also presented important biological behavior. A target fishing study suggested that S-methyl-5-thioadenosine phosphorylase is a potential target to these compounds, which could be explored to enhance activity and decrease the potential toxic side effects. Conclusions: This study shows that 4-phenyl-1,3-thiazol-2-amines could be good scaffolds to the development of new antileishmanial agents. The S-methyl-5-thioadenosine phosphorylase could be one of the macromolecular targets involved in the action.
DOI: 10.6084/m9.figshare.7244279
title: Capsaicinoids and pungency in Capsicum chinense and Capsicum baccatum fruits1

description: ABSTRACT Capsicum chinense Jacq. and C. baccatum var. pendulum fruits are widely used in the food and processed food industry, in Peru, but their seeds and placentas are discarded as residues. This study aimed to quantify the proportion of edible (pericarp) and non-edible (seeds, placenta and interlocular septa) parts of the fruits, in market condition (semi-dried fruits of C. chinense and fresh fruits of C. baccatum), as well as to quantify the capsaicinoids and their pungency, in extracts of each fruit part previously dried. The pericarp represents 63 % and 85 % of the fruit, respectively for C. chinense and C. baccatum. The placenta stands for ~10 % of the fruit in both species, whereas, for the seeds, the index is 23 % in C. chinense and 5 % in C. baccatum. The content of capsaicinoids and pungency vary among the fruit parts and the species. High contents of capsaicinoids and pungency are found in non-edible parts of the fruit, mainly in the placenta (79 % in C. chinense and 51 % in C. baccatum). Regardless of the fruit part and species, the capsaicin was the major component of capsaicinoids (4,399 ug g-1 and 1,582 ug g-1 of the dry weight in C. chinense and C. baccatum, respectively), while dihydrocapsaicin and nordihydrocapsaicin reached a lower content. C. chinense contains more capsaicinoids and, thus, a much higher level of pungency than the C. baccatum fruits.
DOI: 10.6084/m9.figshare.7244276.v1
title: 4-Phenyl-1,3-thiazole-2-amines as scaffolds for new antileishmanial agents

description: Abstract Background: There is still a need for new alternatives in pharmacological therapy for neglected diseases, as the drugs available show high toxicity and parenteral administration. That is the case for the treatment of leishmaniasis, particularly to the cutaneous clinical form of the disease. In this study, we present the synthesis and biological screening of eight 4-phenyl-1,3-thiazol-2-amines assayed against Leishmania amazonensis. Herein we propose that these compounds are good starting points for the search of new antileishmanial drugs by demonstrating some of the structural aspects which could interfere with the observed activity, as well as suggesting potential macromolecular targets. Methods: The compounds were easily synthesized by the methodology of Hantzsch and Weber, had their purities determined by Gas Chromatography-Mass spectrometry and assayed against the promastigote forms of Leishmania amazonensis as well as against two white cell lines (L929 and THP-1) and the monkey's kidney Vero cells. PrestoBlue® and MTT viability assays were the methodologies applied to measure the antileishmanial and cytotoxic activities, respectively. A molecular modeling target fishing study was performed aiming to propose potential macromolecular targets which could explain the observed biological behavior. Results: Four out of the eight compounds tested exhibited important anti-promastigote activity associated with good selectivity indexes when considering Vero cells. For the most promising compound, compound 6, IC50 against promastigotes was 20.78 while SI was 5.69. Compounds 3 (IC50: 46.63 μM; SI: 26.11) and 4 (IC50: 53.12 μM; SI: 4.80) also presented important biological behavior. A target fishing study suggested that S-methyl-5-thioadenosine phosphorylase is a potential target to these compounds, which could be explored to enhance activity and decrease the potential toxic side effects. Conclusions: This study shows that 4-phenyl-1,3-thiazol-2-amines could be good scaffolds to the development of new antileishmanial agents. The S-methyl-5-thioadenosine phosphorylase could be one of the macromolecular targets involved in the action.
DOI: 10.6084/m9.figshare.7244279.v1
title: Capsaicinoids and pungency in Capsicum chinense and Capsicum baccatum fruits1

description: ABSTRACT Capsicum chinense Jacq. and C. baccatum var. pendulum fruits are widely used in the food and processed food industry, in Peru, but their seeds and placentas are discarded as residues. This study aimed to quantify the proportion of edible (pericarp) and non-edible (seeds, placenta and interlocular septa) parts of the fruits, in market condition (semi-dried fruits of C. chinense and fresh fruits of C. baccatum), as well as to quantify the capsaicinoids and their pungency, in extracts of each fruit part previously dried. The pericarp represents 63 % and 85 % of the fruit, respectively for C. chinense and C. baccatum. The placenta stands for ~10 % of the fruit in both species, whereas, for the seeds, the index is 23 % in C. chinense and 5 % in C. baccatum. The content of capsaicinoids and pungency vary among the fruit parts and the species. High contents of capsaicinoids and pungency are found in non-edible parts of the fruit, mainly in the placenta (79 % in C. chinense and 51 % in C. baccatum). Regardless of the fruit part and species, the capsaicin was the major component of capsaicinoids (4,399 ug g-1 and 1,582 ug g-1 of the dry weight in C. chinense and C. baccatum, respectively), while dihydrocapsaicin and nordihydrocapsaicin reached a lower content. C. chinense contains more capsaicinoids and, thus, a much higher level of pungency than the C. baccatum fruits.
DOI: 10.7284/135121
title: Gravimeter data collected during research cruise SKQ201912S using a Bell BGM-3 instrument system onboard the platform RV Sikuliaq

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7244273
title: Students with Deafness in Brazil: Spaces of Schooling and Academic Production in Three Different Regional Contexts

description: ABSTRACT: This paper presents results of a research that had as objective to analyze the schooling of pupils with deafness, considering the educational and academic production indexes on this theme, in three Brazilian States. The interest in researching about this phenomenon is justified by the increased contemporary debate on the schooling of students with disabilities and by the changes in the Brazilian educational laws, which indicates that the schooling of these pupils must occur in the common classrooms of Regular Education. The study has a qualitative nature, and it was based on documentary analysis, combined with bibliographical revision and the search of schooling indexes. It was possible to identify that there were intense changes in the schooling of students with deafness, with the increase of school enrollment in Regular Education and the decrease of school enrollment in Special Education; this happened especially in the States of Espírito Santo and São Paulo, and with lower frequency in the State of Rio Grande do Sul. Regarding the academic production developed by Graduate studies programs in Education in the different states, it was perceived that the themes investigated with higher frequency are linked to the changes that occurred in the contexts of reference of each program.
DOI: 10.6084/m9.figshare.7244273.v1
title: Students with Deafness in Brazil: Spaces of Schooling and Academic Production in Three Different Regional Contexts

description: ABSTRACT: This paper presents results of a research that had as objective to analyze the schooling of pupils with deafness, considering the educational and academic production indexes on this theme, in three Brazilian States. The interest in researching about this phenomenon is justified by the increased contemporary debate on the schooling of students with disabilities and by the changes in the Brazilian educational laws, which indicates that the schooling of these pupils must occur in the common classrooms of Regular Education. The study has a qualitative nature, and it was based on documentary analysis, combined with bibliographical revision and the search of schooling indexes. It was possible to identify that there were intense changes in the schooling of students with deafness, with the increase of school enrollment in Regular Education and the decrease of school enrollment in Special Education; this happened especially in the States of Espírito Santo and São Paulo, and with lower frequency in the State of Rio Grande do Sul. Regarding the academic production developed by Graduate studies programs in Education in the different states, it was perceived that the themes investigated with higher frequency are linked to the changes that occurred in the contexts of reference of each program.