cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.7284/106769
title: Singlebeam Echosounder data collected during research cruise W1104A using a Knudsen 3260 instrument system onboard the platform RV Wecoma

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.25377/sussex.7172519
title: Data from the behavioural experiments described in the paper: Decreased olfactory discrimination is associated with impulsivity in healthy volunteers

description: <b>Data for paper appearing in Scientific Reports</b><br>Excel workbooks containing data collected and analysed in the paper: "Decreased olfactory discrimination is associated with impulsivity in healthy volunteers". The dataset contains sample demographic, behavioural performance on impulsivity tasks, and olfaction measures. <b><br></b><br><b>Abstract of the paper</b><b><br></b>In clinical populations, olfactory abilities parallel executive function, implicating shared neuroanatomical substrates within the ventral prefrontal cortex. In healthy individuals, the relationship between olfaction and personality traits or certain cognitive and behavioural characteristics remains unexplored. We therefore tested if olfactory function is associated with trait and behavioural impulsivity in nonclinical individuals. <br>Eighty-three healthy volunteers (50 females) underwent quantitative assessment of olfactory function (odour detection threshold, discrimination, and identification). Each participant was rated for trait impulsivity index using the Barratt Impulsiveness Scale and performed a battery of tasks to assess behavioural impulsivity (Stop Signal Task, SST; Information Sampling Task, IST; Delay Discounting). <br>Lower odour discrimination predicted high ratings in non-planning impulsivity (Barratt Non-Planning impulsivity subscale); both, lower odour discrimination and detection threshold predicted low inhibitory control (SST; increased motor impulsivity). <br>These findings extend clinical observations to support the hypothesis that deficits in olfactory ability are linked to impulsive tendencies within the healthy population. In particular, the relationship between olfactory abilities and behavioural inhibitory control (in the SST) reinforces evidence for functional overlap between neural networks involved in both processes. These findings may usefully inform the stratification of people at risk from impulse-control-related problems and support planning early clinical interventions
DOI: 10.7284/107049
title: Water Temperature data collected during research cruise W1104A using a Sea-Bird SBE-38 instrument system onboard the platform RV Wecoma

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.17028/rd.lboro.7172516
title: SI files for "A new NiCe complex derived from ortho-vanillin: Structural characterization and luminescence properties"

description: These are the SI files for "A new NiCe complex derived from ortho-vanillin: Structural characterization and luminescence properties".<br>Abstract for associated article:In this study, a new heteronuclear NiCe complex [NiL2Ce(NO3)2(OAc)(H2O)(X)]·1.25H2O (where L = ortovanillinato; X: H2O or CH3OH) was prepared and characterized by analytical and spectroscopic methods. Molecular structure of the complex was further characterised by single crystal X-ray diffraction study. In the structure of the complex, there are two geometrical isomers with only water as coordinated solvent at the Ni(II) centre, and two others with part water and part methanol at this site. In the structure of the complex, a NiL2 moiety is bound to the Ce(III) ion via two phenolic and two methoxy oxygen atoms of two ligands L. The coordination sphere of the Ce(III) ion is completed by the coordination of oxygen atoms of two bidentate nitrate anions, an acetate which bridges the two metal ions, and a water ligand. Hirshfeld surface analysis was performed to investigate the intermolecular contacts and their percentage contributions within the crystal packing. The complex molecules are linked by hydrogen bond contacts. The complex shows an emission band at 656 nm when excited at 317 nm with large stokes shift. The complex exhibits a reversible redox potential at –0.36 V due to the cerium-based oxidation/reduction process.<br>
DOI: 10.25377/sussex.7172519.v1
title: Data from the behavioural experiments described in the paper: Decreased olfactory discrimination is associated with impulsivity in healthy volunteers

description: <b>Data for paper appearing in Scientific Reports</b><br>Excel workbooks containing data collected and analysed in the paper: "Decreased olfactory discrimination is associated with impulsivity in healthy volunteers". The dataset contains sample demographic, behavioural performance on impulsivity tasks, and olfaction measures. <b><br></b><br><b>Abstract of the paper</b><b><br></b>In clinical populations, olfactory abilities parallel executive function, implicating shared neuroanatomical substrates within the ventral prefrontal cortex. In healthy individuals, the relationship between olfaction and personality traits or certain cognitive and behavioural characteristics remains unexplored. We therefore tested if olfactory function is associated with trait and behavioural impulsivity in nonclinical individuals. <br>Eighty-three healthy volunteers (50 females) underwent quantitative assessment of olfactory function (odour detection threshold, discrimination, and identification). Each participant was rated for trait impulsivity index using the Barratt Impulsiveness Scale and performed a battery of tasks to assess behavioural impulsivity (Stop Signal Task, SST; Information Sampling Task, IST; Delay Discounting). <br>Lower odour discrimination predicted high ratings in non-planning impulsivity (Barratt Non-Planning impulsivity subscale); both, lower odour discrimination and detection threshold predicted low inhibitory control (SST; increased motor impulsivity). <br>These findings extend clinical observations to support the hypothesis that deficits in olfactory ability are linked to impulsive tendencies within the healthy population. In particular, the relationship between olfactory abilities and behavioural inhibitory control (in the SST) reinforces evidence for functional overlap between neural networks involved in both processes. These findings may usefully inform the stratification of people at risk from impulse-control-related problems and support planning early clinical interventions
DOI: 10.6084/m9.figshare.7172513
title: Interdependence and asymmetries: Latin American ADRs and developed markets

description: ABSTRACT The ADRs market presented great growing importance in the last decades, specially for companies based on developing countries, such as those of Latin America. In this context, this research sought to detect and measure the interdependence phenomenon, comprising the returns and volatility spillovers and their asymmetries between the levels 2 and 3 ADRs of the main capital markets of Latin America (Brazil, Argentina, Chile and Mexico) and the developed ones (the United States, Japan, the United Kingdom and France), regarding the last financial crisis scope. This phenomenon was investigated considering both the daily returns of their market stock indices, such as those of the ADRs indices created in this study, from June 2008 to May, 2015, via VAR-MGARCH multivaried skewness models, with diagonal VECH representation. The main conclusion was that the ADR indices presented greater interdependence with the developed countries, compared to the analyzed Latin American equity markets.
DOI: 10.17028/rd.lboro.7172516.v1
title: SI files for "A new NiCe complex derived from ortho-vanillin: Structural characterization and luminescence properties"

description: These are the SI files for "A new NiCe complex derived from ortho-vanillin: Structural characterization and luminescence properties".<br>Abstract for associated article:In this study, a new heteronuclear NiCe complex [NiL2Ce(NO3)2(OAc)(H2O)(X)]·1.25H2O (where L = ortovanillinato; X: H2O or CH3OH) was prepared and characterized by analytical and spectroscopic methods. Molecular structure of the complex was further characterised by single crystal X-ray diffraction study. In the structure of the complex, there are two geometrical isomers with only water as coordinated solvent at the Ni(II) centre, and two others with part water and part methanol at this site. In the structure of the complex, a NiL2 moiety is bound to the Ce(III) ion via two phenolic and two methoxy oxygen atoms of two ligands L. The coordination sphere of the Ce(III) ion is completed by the coordination of oxygen atoms of two bidentate nitrate anions, an acetate which bridges the two metal ions, and a water ligand. Hirshfeld surface analysis was performed to investigate the intermolecular contacts and their percentage contributions within the crystal packing. The complex molecules are linked by hydrogen bond contacts. The complex shows an emission band at 656 nm when excited at 317 nm with large stokes shift. The complex exhibits a reversible redox potential at –0.36 V due to the cerium-based oxidation/reduction process.<br>
DOI: 10.6084/m9.figshare.7172513.v1
title: Interdependence and asymmetries: Latin American ADRs and developed markets

description: ABSTRACT The ADRs market presented great growing importance in the last decades, specially for companies based on developing countries, such as those of Latin America. In this context, this research sought to detect and measure the interdependence phenomenon, comprising the returns and volatility spillovers and their asymmetries between the levels 2 and 3 ADRs of the main capital markets of Latin America (Brazil, Argentina, Chile and Mexico) and the developed ones (the United States, Japan, the United Kingdom and France), regarding the last financial crisis scope. This phenomenon was investigated considering both the daily returns of their market stock indices, such as those of the ADRs indices created in this study, from June 2008 to May, 2015, via VAR-MGARCH multivaried skewness models, with diagonal VECH representation. The main conclusion was that the ADR indices presented greater interdependence with the developed countries, compared to the analyzed Latin American equity markets.
DOI: 10.7284/106930
title: Winch data collected during research cruise W1104A using a Markey DUSH-5 instrument system onboard the platform RV Wecoma

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/105066
title: GNSS (Global Navigation Satellite System) data collected during research cruise W1104B using a Ashtech ADU5 instrument system onboard the platform RV Wecoma

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/107055
title: GNSS (Global Navigation Satellite System) data collected during research cruise W1104B using a Garmin GPS-17HVS instrument system onboard the platform RV Wecoma
DOI: 10.6084/m9.figshare.7172468
title: Engineering resistance against <i>Tomato yellow leaf curl virus</i> via the CRISPR/Cas9 system in tomato

description: CRISPR/Cas systems confer molecular immunity against phages and conjugative plasmids in prokaryotes. Recently, CRISPR/Cas9 systems have been used to confer interference against eukaryotic viruses. Here, we engineered <i>Nicotiana benthamiana</i> and tomato (<i>Solanum lycopersicum</i>) plants with the CRISPR/Cas9 system to confer immunity against the <i>Tomato yellow leaf curl virus</i> (TYLCV). Targeting the TYLCV genome with Cas9-single guide RNA at the sequences encoding the coat protein (CP) or replicase (Rep) resulted in efficient virus interference, as evidenced by low accumulation of the TYLCV DNA genome in the transgenic plants. The CRISPR/Cas9-based immunity remained active across multiple generations in the <i>N. benthamiana</i> and tomato plants. Together, our results confirmed the efficiency of the CRISPR/Cas9 system for stable engineering of TYLCV resistance in <i>N. benthamiana</i> and tomato, and opens the possibilities of engineering virus resistance against single and multiple infectious viruses in other crops.
DOI: 10.6084/m9.figshare.7172468.v1
title: Engineering resistance against <i>Tomato yellow leaf curl virus</i> via the CRISPR/Cas9 system in tomato

description: CRISPR/Cas systems confer molecular immunity against phages and conjugative plasmids in prokaryotes. Recently, CRISPR/Cas9 systems have been used to confer interference against eukaryotic viruses. Here, we engineered <i>Nicotiana benthamiana</i> and tomato (<i>Solanum lycopersicum</i>) plants with the CRISPR/Cas9 system to confer immunity against the <i>Tomato yellow leaf curl virus</i> (TYLCV). Targeting the TYLCV genome with Cas9-single guide RNA at the sequences encoding the coat protein (CP) or replicase (Rep) resulted in efficient virus interference, as evidenced by low accumulation of the TYLCV DNA genome in the transgenic plants. The CRISPR/Cas9-based immunity remained active across multiple generations in the <i>N. benthamiana</i> and tomato plants. Together, our results confirmed the efficiency of the CRISPR/Cas9 system for stable engineering of TYLCV resistance in <i>N. benthamiana</i> and tomato, and opens the possibilities of engineering virus resistance against single and multiple infectious viruses in other crops.
DOI: 10.7284/106936
title: Winch data collected during research cruise W1104B using a Markey DUSH-5 instrument system onboard the platform RV Wecoma

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/106774
title: ADCP (Acoustic Doppler Current Profiler) data collected during research cruise W1105A using a Hawaii UHDAS instrument system onboard the platform RV Wecoma

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/106940
title: Anemometer data collected during research cruise W1105A using a RM Young 05103 instrument system onboard the platform RV Wecoma

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/106941
title: Anemometer data collected during research cruise W1105A using a RM Young 05103 instrument system onboard the platform RV Wecoma

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/106938
title: Fluorometer data collected during research cruise W1105A using a Turner 10-AU instrument system onboard the platform RV Wecoma

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/105067
title: GNSS (Global Navigation Satellite System) data collected during research cruise W1105A using a Ashtech ADU5 instrument system onboard the platform RV Wecoma

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/107060
title: GNSS (Global Navigation Satellite System) data collected during research cruise W1105A using a Garmin GPS-17HVS instrument system onboard the platform RV Wecoma

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/106939
title: Gyrocompass data collected during research cruise W1105A using a Sperry MK-37 instrument system onboard the platform RV Wecoma

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/106937
title: Meteorological Station data collected during research cruise W1105A using a Vaisala PTU301 instrument system onboard the platform RV Wecoma

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/107056
title: Radiometer data collected during research cruise W1105A using a Eppley RAD instrument system onboard the platform RV Wecoma

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/107057
title: Rain Gauge data collected during research cruise W1105A using a RM Young 50202 instrument system onboard the platform RV Wecoma

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/106773
title: Singlebeam Echosounder data collected during research cruise W1105A using a Knudsen 3260 instrument system onboard the platform RV Wecoma

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7172408
title: Adaptive radiotherapy for head and neck cancer

description: <b>Introduction:</b> Large anatomical variations can be observed during the treatment course intensity-modulated radiotherapy (IMRT) for head and neck cancer (HNC), leading to potential dose variations. Adaptive radiotherapy (ART) uses one or several replanning sessions to correct these variations and thus optimize the delivered dose distribution to the daily anatomy of the patient. This review, which is focused on ART in the HNC, aims to identify the various strategies of ART and to estimate the dosimetric and clinical benefits of these strategies. <b>Material and methods:</b> We performed an electronic search of articles published in PubMed/MEDLINE and Science Direct from January 2005 to December 2016. Among a total of 134 articles assessed for eligibility, 29 articles were ultimately retained for the review. Eighteen studies evaluated dosimetric variations without ART, and 11 studies reported the benefits of ART. <b>Results:</b> Eight <i>in silico</i> studies tested a number of replanning sessions, ranging from 1 to 6, aiming primarily to reduce the dose to the parotid glands. The optimal timing for replanning appears to be early during the first two weeks of treatment. Compared to standard IMRT, ART decreases the mean dose to the parotid gland from 0.6 to 6 Gy and the maximum dose to the spinal cord from 0.1 to 4 Gy while improving target coverage and homogeneity in most studies. Only five studies reported the clinical results of ART, and three of those studies included a non-randomized comparison with standard IMRT. These studies suggest a benefit of ART in regard to decreasing xerostomia, increasing quality of life, and increasing local control. Patients with the largest early anatomical and dose variations are the best candidates for ART. <b>Conclusion:</b> ART may decrease toxicity and improve local control for locally advanced HNC. However, randomized trials are necessary to demonstrate the benefit of ART before using the technique in routine practice.
DOI: 10.7284/107059
title: Singlebeam Echosounder data collected during research cruise W1105A using a Knudsen 3260 instrument system onboard the platform RV Wecoma

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7172408.v1
title: Adaptive radiotherapy for head and neck cancer

description: <b>Introduction:</b> Large anatomical variations can be observed during the treatment course intensity-modulated radiotherapy (IMRT) for head and neck cancer (HNC), leading to potential dose variations. Adaptive radiotherapy (ART) uses one or several replanning sessions to correct these variations and thus optimize the delivered dose distribution to the daily anatomy of the patient. This review, which is focused on ART in the HNC, aims to identify the various strategies of ART and to estimate the dosimetric and clinical benefits of these strategies. <b>Material and methods:</b> We performed an electronic search of articles published in PubMed/MEDLINE and Science Direct from January 2005 to December 2016. Among a total of 134 articles assessed for eligibility, 29 articles were ultimately retained for the review. Eighteen studies evaluated dosimetric variations without ART, and 11 studies reported the benefits of ART. <b>Results:</b> Eight <i>in silico</i> studies tested a number of replanning sessions, ranging from 1 to 6, aiming primarily to reduce the dose to the parotid glands. The optimal timing for replanning appears to be early during the first two weeks of treatment. Compared to standard IMRT, ART decreases the mean dose to the parotid gland from 0.6 to 6 Gy and the maximum dose to the spinal cord from 0.1 to 4 Gy while improving target coverage and homogeneity in most studies. Only five studies reported the clinical results of ART, and three of those studies included a non-randomized comparison with standard IMRT. These studies suggest a benefit of ART in regard to decreasing xerostomia, increasing quality of life, and increasing local control. Patients with the largest early anatomical and dose variations are the best candidates for ART. <b>Conclusion:</b> ART may decrease toxicity and improve local control for locally advanced HNC. However, randomized trials are necessary to demonstrate the benefit of ART before using the technique in routine practice.
DOI: 10.6084/m9.figshare.7172402
title: Activated kinase screening identifies the <i>IKBKE</i> oncogene as a positive regulator of autophagy

description: Macroautophagy/autophagy is one of the major responses to stress in eukaryotic cells and is implicated in several pathological conditions such as infections, neurodegenerative diseases and cancer. Interestingly, cancer cells take full advantage of autophagy both to support tumor growth in adverse microenvironments and to oppose damages induced by anti-neoplastic therapies. Importantly, different human oncogenes are able to modulate this survival mechanism to support the transformation process, ultimately leading to ‘autophagy addiction’. Still, oncogenic signaling events, impinging on the control of autophagy, are poorly characterized, limiting our possibilities to take advantage of these mechanisms for therapeutic purposes. Here, we screened a library of activated kinases for their ability to stimulate autophagy. By this approach, we identified novel potential regulators of the autophagic process and, among them, the IKBKE oncogene. Specifically, we demonstrate that this oncoprotein is able to stimulate autophagy when overexpressed, an event frequently found in breast tumors, and that its activity is strictly required for breast cancer cells to support the autophagic process. Interestingly, different oncogenic pathways typically involved in breast cancer, namely ERBB2 and PI3K-AKT-MTOR, also rely on IKBKE to control this process. Ultimately, we show that IKBKE-dependent autophagy is necessary for breast cancer cell proliferation, suggesting an important supporting role for this oncogene and autophagy in these tumors. <b>Abbreviations:</b> AAK1: AP2 associated kinase 1; AMPK: 5ʹ-prime-AMP-activated protein kinase; AKT1: AKT serine/threonine kinase 1; BAF: bafilomycin A<sub>1</sub>; CA: constitutively activated; CDK17: cyclin dependent kinase 17; CDK18: cyclin dependent kinase 18; CHUK: conserved helix-loop-helix ubiquitous kinase; EGF: epidermal growth factor; ERBB2: erb-b2 receptor tyrosine kinase 2; FGF: fibroblast growth factor; FM: full medium; GALK2: galactokinase 2; IKBKB: inhibitor of nuclear factor kappa B kinase subunit beta; IKBKE: inhibitor of nuclear factor kappa B kinase subunit epsilon; IKK: IκB kinase complex; KD: kinase dead; MAP1LC3B/LC3B: microtubule associated protein 1 light chain 3 beta; MAPK1: mitogen-activated protein kinase 1; MAPK15: mitogen-activated protein kinase 15; MTORC1: mammalian target of rapamycin kinase complex 1; myr: myristoylation/myristoylated; NFKBIA: NFKB inhibitor alpha; PDGF: platelet derived growth factor; PFKL: phosphofructokinase, liver type; PRKAA1: protein kinase AMP-activated catalytic subunit alpha 1; PRKCD: protein kinase C delta; SQSTM1: sequestosome 1; TBK1: TANK binding kinase 1; TNBC: triple-negative breast cancer; TSC2: TSC complex subunit 2; WB: western blot; WT: wild-type.
DOI: 10.7284/107058
title: Water Temperature data collected during research cruise W1105A using a Sea-Bird SBE-38 instrument system onboard the platform RV Wecoma

description: Original (unprocessed) data collected during a Field_expedition