cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.14345852
title: Supplementary Material for: Tapering and Discontinuation of Thrombopoietin Receptor Agonist Therapy in Patients with Immune Thrombocytopenia: Results from a Modified Delphi Panel

description: <b><i>Background:</i></b> Recent evidence suggests that in patients with immune thrombocytopenia (ITP) with a stable response on thrombopoietin receptor agonists, treatment may be tapered and/or discontinued. <b><i>Objectives:</i></b> The objective of this study was to provide a guide for tapering and discontinuation of TPO-RA therapy in patients with ITP, based on hematologist survey results, existing evidence, and expert consensus. <b><i>Patients/Methods:</i></b> UK hematologists completed a survey to characterize self-reported practice patterns related to TPO-RA tapering and discontinuation in patients with ITP. Using a modified Delphi panel approach, ITP experts developed consensus statements regarding the use of TPO-RA tapering and discontinuation. <b><i>Results:</i></b> Survey respondents estimated that 30–34% of their patients were suitable for tapering or discontinuation and that 29–35% of these patients required treatment re-initiation after an average treatment-free interval of 86–106 days. No clear predictors of patient suitability or response to tapering or discontinuation were identified. The ITP expert consensus was that approximately 30% of patients are eligible for tapering and discontinuation, which may be considered after 6–12 months for patients demonstrating an adequate treatment response (platelet count &gt;50,000/µL at ≥75% of assessments in the preceding 6 months). Treatment re-initiation may be considered if the platelet count decreases or if the patient becomes symptomatic. Individual differences need to be taken into account when considering TPO-RA tapering or discontinuation. <b><i>Conclusions:</i></b> Tapering and discontinuation of TPO-RA therapy may be considered for certain patients with ITP. Further study is needed to better predict patients likely to achieve sustained off-treatment responses after tapering and discontinuation.
DOI: 10.6084/m9.figshare.14345852.v1
title: Supplementary Material for: Tapering and Discontinuation of Thrombopoietin Receptor Agonist Therapy in Patients with Immune Thrombocytopenia: Results from a Modified Delphi Panel

description: <b><i>Background:</i></b> Recent evidence suggests that in patients with immune thrombocytopenia (ITP) with a stable response on thrombopoietin receptor agonists, treatment may be tapered and/or discontinued. <b><i>Objectives:</i></b> The objective of this study was to provide a guide for tapering and discontinuation of TPO-RA therapy in patients with ITP, based on hematologist survey results, existing evidence, and expert consensus. <b><i>Patients/Methods:</i></b> UK hematologists completed a survey to characterize self-reported practice patterns related to TPO-RA tapering and discontinuation in patients with ITP. Using a modified Delphi panel approach, ITP experts developed consensus statements regarding the use of TPO-RA tapering and discontinuation. <b><i>Results:</i></b> Survey respondents estimated that 30–34% of their patients were suitable for tapering or discontinuation and that 29–35% of these patients required treatment re-initiation after an average treatment-free interval of 86–106 days. No clear predictors of patient suitability or response to tapering or discontinuation were identified. The ITP expert consensus was that approximately 30% of patients are eligible for tapering and discontinuation, which may be considered after 6–12 months for patients demonstrating an adequate treatment response (platelet count &gt;50,000/µL at ≥75% of assessments in the preceding 6 months). Treatment re-initiation may be considered if the platelet count decreases or if the patient becomes symptomatic. Individual differences need to be taken into account when considering TPO-RA tapering or discontinuation. <b><i>Conclusions:</i></b> Tapering and discontinuation of TPO-RA therapy may be considered for certain patients with ITP. Further study is needed to better predict patients likely to achieve sustained off-treatment responses after tapering and discontinuation.
DOI: 10.5281/zenodo.4650245
title: Appendix 1S: Complete dataset with viral Blastn hits from rectal and nasal swabs collected from semi-domesticated and wild Eurasian tundra reindeer (Rangifer tarandus tarandus) in Sweden, Norway, Finland, Iceland and Russia in different geographical locations and during two separate sampling periods.

description: Dataset with viral Blastn hits from rectal and nasal swabs collected from semi-domesticated Eurasian tundra reindeer (<em>Rangifer tarandus tarandus</em>) in Sweden (Regions A, B, C), Norway (Regions A, B, C), Finland (Regions A, B, C) and Yakutia, Russia (Regions A, B, C) and wild Eurasian tundra reindeer from all hunting areas in Iceland during two separate sampling periods.
DOI: 10.5281/zenodo.4650244
title: Appendix 1S: Complete dataset with viral Blastn hits from rectal and nasal swabs collected from semi-domesticated and wild Eurasian tundra reindeer (Rangifer tarandus tarandus) in Sweden, Norway, Finland, Iceland and Russia in different geographical locations and during two separate sampling periods.

description: Dataset with viral Blastn hits from rectal and nasal swabs collected from semi-domesticated Eurasian tundra reindeer (<em>Rangifer tarandus tarandus</em>) in Sweden (Regions A, B, C), Norway (Regions A, B, C), Finland (Regions A, B, C) and Yakutia, Russia (Regions A, B, C) and wild Eurasian tundra reindeer from all hunting areas in Iceland during two separate sampling periods.
DOI: 10.6084/m9.figshare.13603289
title: Size-dependent chemical depletion of sediments in glacial environments: a case study of Mandakini Valley, central Himalaya, India

description: The size-dependent chemical maturity of sediment cycling in a high-altitude glacial/periglacial environment was studied by examining the sediments of the Chorabari Glacier, Mandakini Valley, central Himalaya, India. Sediments evacuated from glacial debris and a periglacial area were studied via particle-size analysis, X-ray fluorescence, and X-ray diffraction of different grain-size fractions. The results suggest a clear control of grain-size fraction over chemical weathering and release of its attendant nutrients from the glacial substrate. Elemental indices suggest the release of nutrients is principally controlled through comminution and sub-glacial chemical weathering of leachable minerals such as feldspar, mica, and apatite. Owing to biogeochemical cycles, the release of nutrients like phosphorous and calcium is predominantly controlled through mineral dissolution process of aluminosilicate rocks containing apatite, carbonate minerals and organic complexes. Overall, the size-dependent chemical maturity of glacial sediments suggests a much more chemically active system than previously thought. This study is of particular importance for downstream weathering tracer studies of detrital sediments.
DOI: 10.6084/m9.figshare.13603289.v2
title: Size-dependent chemical depletion of sediments in glacial environments: a case study of Mandakini Valley, central Himalaya, India

description: The size-dependent chemical maturity of sediment cycling in a high-altitude glacial/periglacial environment was studied by examining the sediments of the Chorabari Glacier, Mandakini Valley, central Himalaya, India. Sediments evacuated from glacial debris and a periglacial area were studied via particle-size analysis, X-ray fluorescence, and X-ray diffraction of different grain-size fractions. The results suggest a clear control of grain-size fraction over chemical weathering and release of its attendant nutrients from the glacial substrate. Elemental indices suggest the release of nutrients is principally controlled through comminution and sub-glacial chemical weathering of leachable minerals such as feldspar, mica, and apatite. Owing to biogeochemical cycles, the release of nutrients like phosphorous and calcium is predominantly controlled through mineral dissolution process of aluminosilicate rocks containing apatite, carbonate minerals and organic complexes. Overall, the size-dependent chemical maturity of glacial sediments suggests a much more chemically active system than previously thought. This study is of particular importance for downstream weathering tracer studies of detrital sediments.
DOI: 10.6084/m9.figshare.13603289.v1
title: Size-dependent chemical depletion of sediments in glacial environments: a case study of Mandakini valley, central Himalaya, India

description: The size-dependent chemical maturity of sediment cycling in high-altitude glacial/periglacial environment was studied by examining the sediments of the Chorabari Glacier, Mandakini valley, central Himalaya, India. Sediments evacuated from glacial debris and periglacial area were studied through particle-size analysis, X-ray fluorescence, and X-ray diffraction of different grain-size fractions. The results suggest a clear control of grain-size fraction over chemical weathering and its attendant nutrients release from glacial substrate. Elemental indices suggest the release of nutrients is principally controlled through comminution process and sub-glacial chemical weathering of leachable minerals like feldspar, mica, and apatite. Owing to biogeochemical cycles, the release of phosphorus and calcium is predominantly controlled through apatite, organic complexes, and carbonate dissolution of aluminosilcate rocks respectively. Overall, the size-dependent chemical maturity of glacial sediments suggests a much chemically active system than previously thought. This study is explicitly important for downstream weathering tracer studies of detrital sediments.
DOI: 10.15161/oar.it/73618
title: CovidStat project data

description: This record contains the daily updated data of the CovidStat project. CovidStat is a project carried out by the CovidStat Working Group at INFN, whose creation was promoted within the Italian National Institute of Nuclear Physics with the aim of making a statistical analysis of the data provided daily by the Civil Protection on the spread of the pandemic in Italy. CovidStat data can interactively be browsed at https://covid19.infn.it.
description: The software to process this Root TTree is in the related identifier. Be sure to use the right corresponding version, based on the data in which Root TTree was generated.
DOI: 10.5517/ccdc.csd.cc98wp3
title: CCDC 276665: Experimental Crystal Structure Determination

description: Related Article: P.F. Rapheal, E. Manoj, M.R. Prathapachandra Kurup, P. Venugopalan|2021|Chem. Data Collect.|33|100681|doi:10.1016/j.cdc.2021.100681
DOI: 10.5517/ccdc.csd.cc240m3x
title: CCDC 1966798: Experimental Crystal Structure Determination

description: Related Article: Natarajan Arumugam, Abdulrahman I. Almansour, Raju Suresh Kumar, Vagolu Siva Krishna, Dharmarajan Sriram, Necmi Dege|2021|Bioorg.Chem.|110|104798|doi:10.1016/j.bioorg.2021.104798
DOI: 10.5517/ccdc.csd.cc24q8jp
title: CCDC 1987612: Experimental Crystal Structure Determination

description: Related Article: Raed M. Al-Zoubi, Noor H. Al-Shatnawi, Walid K. Al-Jammal, Abdlateef Ibdah, Mazhar S. Al-Zoubi, Michael J. Ferguson, Ahmad S. Zarour, Aksam A. Yassin, Abdullah A. Ansari|2021|J.Organomet.Chem.|940|121786|doi:10.1016/j.jorganchem.2021.121786
DOI: 10.25919/vdd2-b027
title: Parkes observations for project P456 semester 2020OCTS_13

description: The Parkes Pulsar Timing Array (PPTA) project has three primary goals: (a) detection of gravitational waves from astronomical sources, (b) establishment of a pulsar timescale, and (c) improvement of our understanding of Solar-system dynamics. The PPTA is the oldest of three international pulsar timing groups. We have the smallest telescope and the smallest group, but the best measurements and the best results. Our bound on the strength of the incoherent gravitational wave background is the only bound which significantly constrains theoretical models. We have maintained our leading position because: we have the southern sky; we have a small but well-focussed group; we have the best-calibrated receivers; and we have been able to observe with an almost regular cadence of 15 to 20 days over a wide bandwidth. With this proposal we aim to maintain our pre-eminent position in the field. Unlike most observing proposals, this is a continuing proposal for which the observations will continue to improve bounds on ultra-low-frequency gravitational waves until they are finally detected. Continued Parkes observations will remain valuable at least until the first stage of the SKA is able to improve on our sensitivity and observing cadence. Even after the gravitational wave background is detected we will want to continue observations in support of the nascent field of gravitational wave astronomy!
DOI: 10.6084/m9.figshare.12789941
title: Supplementary data and research materials for "The propagation effect of commuting to work in the spatial transmission of COVID-19"

description: This project folder contains supplementary data files and software codes (Stata) to replicate the estimation and simulation results documented in:<br><br>"The propagation effect of commuting to work in the spatial transmission of COVID-19", written by Mitze, T. and Kosfeld, R. (2020).<br>Forthcoming in: Journal of Geographical Systems<br><br>A Preprint of this research work (latest version: 22-03-2021) is attached to the supplementary materials on Figshare.<br>
DOI: 10.6084/m9.figshare.12789941.v3
title: Supplementary data and research materials for "The propagation effect of commuting to work in the spatial transmission of COVID-19"

description: This project folder contains supplementary data files and software codes (Stata) to replicate the estimation and simulation results documented in:<br><br>"The propagation effect of commuting to work in the spatial transmission of COVID-19", written by Mitze, T. and Kosfeld, R. (2020).<br>Forthcoming in: Journal of Geographical Systems<br><br>A Preprint of this research work (latest version: 22-03-2021) is attached to the supplementary materials on Figshare.<br>
DOI: 10.6084/m9.figshare.12789941.v2
title: Supplementary data and research materials for "The propagation effect of commuting to work in the spatial transmission of Covid-19"

description: This project folder contains supplementary data files and software codes (Stata) to replicate the estimation and simulation results documented in:<br><br>"The propagation effect of commuting to work in the spatial transmission of Covid-19", written by Mitze, T. and Kosfeld, R. (2020).<br>A preprint of this research work (current version: 22-12-2020) is linked to the supplementary materials on Figshare.<br>
DOI: 10.6084/m9.figshare.14345888
title: Supplementary Material for: Association of Progressive Supranuclear Palsy Rating Scale with Progressive Supranuclear Palsy Quality of Life Scale

description: <b><i>Introduction:</i></b> There is growing interest in using patient-reported outcomes as end points in clinical trials, such as the progressive supranuclear palsy quality of life (PSP-QoL) scale. However, this tool has not been widely validated and its correlation with validated motor scales has not been explored. To evaluate the potential utility of using PSP-QoL as an outcome, it is important to examine its relationship with a standard scale used to evaluate neurologic parameters, such as the PSP Rating Scale. <b><i>Methods:</i></b> PSP-QoL and PSP Rating Scale scores were gathered from 60 clinically diagnosed PSP patients, including patients with Richardson syndrome PSP (PSP-RS, <i>n</i> = 43) and those with non-RS PSP variants (<i>n</i> = 17). Linear regression analysis adjusted for age, sex, and disease duration was used to evaluate the cross-sectional relationship between the total and subscale scores of the 2 instruments. <b><i>Results:</i></b> Among 60 PSP patients, there was a significant correlation between total PSP-QoL and PSP Rating Scale scores. The physical and mentation subscales of each instrument also demonstrated significant correlations. Comparisons among PSP subtypes indicated that worsening PSP-QoL Total and Physical subscale scores correlated with worsening PSP Rating Scale gait subscale scores more strongly for the non-RS PSP variants than for PSP-RS. <b><i>Discussion:</i></b> There is a significant association between the total scores and many of the subscale scores of the PSP-QoL and the PSP Rating Scale. Additionally, the relationship between these measures may differ for PSP-RS and non-RS variants. These findings suggest that the PSP-QoL may be useful in clinical trials as a patient-reported outcome measure. Large prospective multicenter studies utilizing the PSP-QoL are necessary to examine its relationship to disease evolution and changes in the PSP Rating Scale.
DOI: 10.6084/m9.figshare.14345882
title: Supplementary Material for: Development of an Online App to Predict Post-Endoscopic Retrograde Cholangiopancreatography Adverse Events Using a Single-Center Retrospective Cohort

description: <b><i>Introduction:</i></b> Endoscopic retrograde cholangiopancreatography (ERCP) is a technically demanding procedure with a high risk for adverse events (AEs). <b><i>Aim:</i></b> evaluate patient- and procedure-related risk factors for ERCP-related AEs and develop an online app to estimate risk of AEs. <b><i>Methods:</i></b> retrospective study of 1,491 consecutive patients who underwent 1,991 ERCPs between 2012 and 2017 was conducted. AEs definition and severity were classified according to most recent ESGE guidelines. Each variable was tested for association with occurrence of overall AEs, post-ERCP pancreatitis (PEP) and cholangitis. For each outcome, 2 regression models were built, from which an online Shiny-based app was created. <b><i>Results:</i></b> Overall AE rate was 15.3%; in 19 procedures, &gt;1 AE occurred. Main post-ERCP AE was PEP (7.5%), followed by cholangitis (4.9%), bleeding (1.3%), perforation (1%), cardiopulmonary events (0.9%), and cholecystitis (0.3%). Seventy-eight percent of AEs were mild/moderate; of severe (<i>n</i> = 55) and fatal (<i>n</i> = 20) AEs, more than half were related to infection, cardiac/pulmonary AEs, and perforation. AE-related mortality rate was 1%. When testing precannulation, procedural covariates, and ERCP findings, AE occurrence was associated with age (odds ratio [OR] 0.991), previous PEP (OR 2.198), ERCP complexity grade III/IV (OR 1.924), standard bile duct cannulation (OR 0.501), sphincterotomy (OR 1.441), metal biliary stent placement (OR 2.014), periprocedural bleeding (OR 3.024), and biliary duct lithiasis (OR 0.673). <b><i>Conclusion:</i></b> Our app may allow an optimization of the patients’ care, by helping in the process of decision-making, not only regarding patient or endoscopist’s selection but also definition of an adequate and tailored surveillance plan after the procedure.
DOI: 10.6084/m9.figshare.14338916
title: Raw Data Files

description: abg_df.pickle: dataframe containing the names of all German MPs during the 19th election period (starting on 2017-09-24) who possess a public Twitter account, as well as some personal information and Twitter usernames.<br><br>se_df.pickle: dataframe containing socioeconomic information and 2017 election results for all 299 German electoral districts; matchable with abg_df.pickle based on electoral district number.<br>tweepy_df.pickle: dataframe containing all accessible tweets by German MPs from 2017-09-24 through 2020-04-24, scraped using tweepy; using Twitter usernames from abg_df.pickle.
DOI: 10.6084/m9.figshare.14338916.v1
title: Raw Data Files

description: abg_df.pickle: dataframe containing the names of all German MPs during the 19th election period (starting on 2017-09-24) who possess a public Twitter account, as well as some personal information and Twitter usernames.<br><br>se_df.pickle: dataframe containing socioeconomic information and 2017 election results for all 299 German electoral districts; matchable with abg_df.pickle based on electoral district number.<br>tweepy_df.pickle: dataframe containing all accessible tweets by German MPs from 2017-09-24 through 2020-04-24, scraped using tweepy; using Twitter usernames from abg_df.pickle.
DOI: 10.5281/zenodo.4650215
title: Whole-genome analyses of 286 Magnaporthe oryzae genomes suggest that an independent introduction of a global pandemic lineage is at the origin of the Zambia wheat blast outbreak

description: The emergence of agricultural pests is a severe threat to global food security. The recent wheat blast outbreak in Bangladesh had devastating consequences for the country. More recently, a wheat blast outbreak in Zambia was assigned to the same tight group of genotypes originally introduced from Brazil into Bangladesh. Here, I analyzed publicly available whole-genome sequencing datasets shared by the OpenWheatBlast initiative. The aim is to contrast the Zambian outbreak strains with genome-wide differentiation of <em>Magnaporte oryzae </em>infecting different hosts. The genome-wide SNP analyses show that the Zambian outbreak strains are indeed highly similar to the strains responsible for the outbreak in Bangladesh as recently reported. The genomic data suggest that the Zambian outbreak may have originated from Brazil rather than a secondary introduction from the South Asian gene pool. The genome analyses confirm that wheat blast has emerged in recent years as a pandemic lineage across three continents. I provide the analyses as an open science contribution to the OpenWheatBlast initiative.
DOI: 10.6084/m9.figshare.13373867
title: DBEMv3 evaluation input ICME list

description: Supplementary table with the input model data for DBEMv3 evaluation published in paper "Probabilistic Drag-Based Ensemble Model (DBEM) evaluation for heliospheric propagation of CMEs", Calogovic et al., 2021
DOI: 10.6084/m9.figshare.13373867.v1
title: DBEMv3 evaluation input ICME list

description: Supplementary table with the input model data for DBEMv3 evaluation published in paper "Probabilistic Drag-Based Ensemble Model (DBEM) evaluation for heliospheric propagation of CMEs", Calogovic et al., 2021
DOI: 10.5281/zenodo.4650325
title: Dataset related to article "Biallelic mutations in SORD cause a common and potentially treatable hereditary neuropathy with implications for diabetes"

description: Clinical features of patients from C. Besta Institute
description: Study supported by IOWA University
DOI: 10.5281/zenodo.4650324
title: Dataset related to article "Biallelic mutations in SORD cause a common and potentially treatable hereditary neuropathy with implications for diabetes"

description: Clinical features of patients from C. Besta Institute
description: Study supported by IOWA University
DOI: 10.5281/zenodo.4650331
title: Dataset related to article "Optical coherence tomography in adult adrenoleukodystrophy: a cross-sectional and longitudinal study"

description: OCT parameters in the cohort of X-ALD patients and in the age- and sex-matched healthy subjects
description: Study partially funded by the Italian Ministry of Health, Current Research Funds and grant RF-2016- 02361285.
DOI: 10.5281/zenodo.4650330
title: Dataset related to article "Optical coherence tomography in adult adrenoleukodystrophy: a cross-sectional and longitudinal study"

description: OCT parameters in the cohort of X-ALD patients and in the age- and sex-matched healthy subjects
description: Study partially funded by the Italian Ministry of Health, Current Research Funds and grant RF-2016- 02361285.