cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.17632/j7mrkp6kfn.1
title: n vitro Antiviral Activity of the Favipiravir and their 6- and 3-O-Substituted derivatives Against Coronovirus: Acetylation leads Improvement of Antiviral Activity

description: Synthesis and antiviral evaluation of a new series of functionalized favipiravir
The present manuscript described the optimization of the favipiravir as antiviral against in vitro bovine and human models of coronavirus, which was focused on two chemical functionalizations in pyrazine-structure: (i) functionalization at 6-position using halogens (F, Cl, Br and I) and hydrogen, and (ii) functionalization of 3-hydroxyl using different removal groups like acetyl, triflate, methanosulphonic and benzylic moieties. The first functionalization seeks to interpret the role of the tautomerism in the reactivity of the 3-hydroxypyrazine to form the active T07-RTP (T07-ribonucleoside 5′-triphosphate) metabolite, which was a question generated from previous reports in models of influenza (Huchting, J. et al. J. Med. Chem. 2018, 61, 6193-6210; De Almeida La Porta, F. et al. RSC Adv. 2021, 11, 35228 and other reports). Previously, we performed a full study of the tautomerism of this type of 3-hydroxy-2-pyrazinecarboxamides in solid state and in solution (J. Org. Chem. 2023, 88, 10735-10752) and we found that the keto-tautomerization in solution can be favored with diminution of halogen electronegativity as follows: 6-H &gt;&gt; 6-I &gt; 6-Br &gt;&gt; 6-Cl &gt; 6-F. That issue seeks to verify if the modulation of the keto-tautomerization by 6-halogen substitution can favor the antiviral response in coronavirus models, which is novel to the best of our knowledge. 
Regarding the second functionalization, we seek to improve the cell penetration with the functionalization of the 3-hydroxyl moiety using removal lipophilicity moieties, whose final target was to enhance the antiviral response. The bioavailability of the favipiravir is one of its most significant disadvantages for infective in vitro models and more in particular, in vivo and clinical models (Nguyen TH, et al. PLoS Negl Trop Dis 2017;11(2):e0005389). With these chemical variations in favipiravir structure, we found that the modulation of the tautomer via 6-substitution did not provide an improvement in the antiviral response, whereas interestingly, from 3-O-functionalization, we found that the acetylation is a convenient removal moiety because it generated a compound 2-fold more active than favipiravir with a better selectivity against bovine and human model of coronavirus. Also, we demonstrated through NMR and fluorometric analysis that the diacetylated compound released in short time the favipiravir, being the acetylation a convenient chemical function to improve the penetration and accumulation into cell and its rapid release of favipiravir into cell favored the biological profile of the favipiravir as antiviral. This opens the door to the design of functionalized favipiravir and opens new perspectives on the importance of the lipophilicity to improve the antiviral profile of the favipiravir.
DOI: 10.17632/krtw3h4hb2.1
title: Las Palmas_soil moisture

description: These are daily soil moisture data taken from four (4) in-situ stations located in the Las Palmas Basin of the Municipality of Envigado, Colombia. Each station has three soil moisture sensors located at three depths, according to the thickness of each layer in the soil profile. The data was taken from 01-01-2020 to 08-31-2022. The information is in volume (m3/m3). The stations are located in different types of vegetation cover. Two in crop areas (Crop__station and Crop_2_station), one in a grassland area (Grassland_Station) and the fourth in a forest area (Forest_station).
DOI: 10.5281/zenodo.14677519
title: R code and data (Tao et al., 2025)

description: R code and data for the article, A comprehensive and ultrasensitive isotope calibration method for soil amino compounds using Orbitrap mass spectrometry, authored by Tao et al., (2025).
DOI: 10.17632/krh7cy99wg.1
title: A study of "Tocilizumab treated convalescent COVID-19 patients retain the cross-neutralization potential against SARS-CoV-2 variants". Chauvin et al

description: Supplementary Dataset for the manuscript "Tocilizumab treated convalescent COVID-19 patients retain the cross-neutralization potential against SARS-CoV-2 variants". Description of each patient according to disease severity and treatment. 55 out of 69 patients were recruited during the first COVID-19 wave while 14 patients were recruited during the second/third wave of COVID-19.
DOI: 10.17632/6vy2tvv7jn.1
title: Dataset for study: Association between production and reproduction parameters based on parity and breed of dairy cows in the Czech Republic

description: Milk production and the efficiency of dairy cow breeding are significantly influenced by reproductive factors. The purpose of our research was to examine the relationships between selected milk production and reproductive parameters. We evaluated 659 dairy cows, including 444 purebreds from the Czech Fleckvieh and Holstein breeds and 215 crossbreds.
The evaluation included data from January to December 2018. Data on average milk yield per lactation (MY, kg), average fat in milk per lactation (F, kg), average protein in milk per lactation (P, kg), average lactose in milk per lactation (L, kg), average percentage of fat in milk (F%), average percentage of protein in milk (P%), and average percentage of lactose in milk (L%) were measured using the Pulsameter 2 (certified by ICAR, Labor- und Messgeräte GmbH, Germany).
The dataset was further supplemented with data on SP (d), CalvInt (d), and summary selection indices for the Czech Fleckvieh (Genetic Total Merit Index – GZW) and Holstein breed index (Selection Index Holstein – SIH) from the performance control database maintained by the Czech Moravian Breeders Corporation (CˇMSCH;Hradištko, Czech Republic).
This dataset provides key information on dairy cows, including individual IDs, breeding details, calving dates, and lactation periods. It tracks cows' reproductive history (parity and calving intervals) and farm location (Farm ID and Stable ID). The dataset also includes performance metrics (potentially related to breeding and health) and detailed records of milk production, including quantity and content analysis for fat, protein, and lactose.
The dataset could be used for various purposes in the field of dairy cattle research, as it contains valuable information about reproduction and production of many dairy cows over an extended period.
DOI: 10.17632/s58z23mvpw.1
title: Resultados do Tratamento de Lesão Renal Aguda

description: Nas unidades hospitalares, a avaliação e o acompanhamento farmacêutico das prescrições médicas constituem uma importante fonte de assistência farmacêutica. Um problema comum e que apresenta altas taxas de incidência hospitalar é a ocorrência de lesão renal aguda (LRA). A farmacovigilância é implementada em hospitais com a finalidade de monitorar relatos de efeitos adversos relacionados aos medicamentos administrados aos pacientes. O objetivo do estudo é avaliar a incidência de LRA em pacientes internados e expostos a antimicrobianos em um hospital público do estado do Pará, Brasil. Foi realizado um estudo de coorte prospectivo e observacional, cujo desfecho de interesse é a ocorrência de LRA em pacientes internados no hospital entre outubro de 2018 e janeiro de 2019. Os dados foram registrados e armazenados em banco de dados, em seguida foi realizada análise descritiva no GraphPad Programa Prisma 6.0. As variáveis quantitativas foram expressas como desvio padrão (DP) da média e o número de casos como percentual. O estudo foi realizado com 70 pacientes que estavam internados no hospital e necessitaram utilizar algum dos antimicrobianos selecionados no período de observação durante o tratamento hospitalar. Os pacientes acompanhados no estudo eram em sua maioria do sexo masculino (64,29%; n = 45). A idade variou de 19 a 96 anos, com média de 52,49 anos (DP = 20,31). Os pacientes incluídos eram em sua maioria oriundos do ambulatório de oncologia (34,29%; n = 24) e aqueles que haviam sido operados (27,14%; n = 19). A maioria dos pacientes críticos internados na UTI adulto (26,47%; n = 9) desenvolveu LRA. Em relação ao número de medicamentos utilizados pelos pacientes, houve variação de 5 a 17, com média de 10,26 (DP = 2,90) medicamentos prescritos por paciente. Nos dados referentes aos antimicrobianos, a maioria dos pacientes fazia uso de ceftriaxona (n = 29), cefepima (n = 27) e piperacilina/tazobactam (n = 23). Em termos do número de antimicrobianos prescritos por paciente, 60% (n = 42) dos pacientes tomaram apenas um, 30% (n = 21) tomaram dois e 10% (n = 7) tomaram três ou mais antimicrobianos para tratamento de infecções. Durante o período do estudo, as concentrações plasmáticas de vancomicina variaram de 3,0 μg/mL a 22,5 μg/mL. Das 10 amostras coletadas, 10,0% (n = 1) estavam acima da faixa terapêutica estabelecida pela literatura (entre 10 a 20 µg/mL), 30,0% (n = 3) estavam dentro dos valores de referência e 60,0% (n = 6) dos pacientes apresentaram valores abaixo dos valores de referência. Os pacientes que desenvolveram LRA (60,0%; n = 6) durante o uso de vancomicina apresentaram valores de concentração entre 3 µg/mL e 15,9 µg/mL, sendo que a maioria apresentou valores abaixo da faixa terapêutica recomendada. Desses pacientes com LRA, 83,33% (n = 5) utilizaram mais de um antimicrobiano nefrotóxico durante o tratamento hospitalar. As concentrações de pacientes que não foram diagnosticados com LRA (40,0%; n = 4) variaram de 3,0 µg/mL a 22,5 µg/mL.
DOI: 10.17632/s58z23mvpw.2
title: RESULTADO DE DADOS ANTIMICROBIANO E OCORRÊNCIA DE LESÃO RENAL AGUDA EM PACIENTES INTERNADOS EM UM HOSPITAL NO OESTE DO PARÁ, BRASIL.

description: Nas unidades hospitalares, a avaliação e o acompanhamento farmacêutico das prescrições médicas constituem uma importante fonte de assistência farmacêutica. Um problema comum e que apresenta altas taxas de incidência hospitalar é a ocorrência de lesão renal aguda (LRA). A farmacovigilância é implementada em hospitais com a finalidade de monitorar relatos de efeitos adversos relacionados aos medicamentos administrados aos pacientes. O objetivo do estudo é avaliar a incidência de LRA em pacientes internados e expostos a antimicrobianos em um hospital público do estado do Pará, Brasil. Foi realizado um estudo de coorte prospectivo e observacional, cujo desfecho de interesse é a ocorrência de LRA em pacientes internados no hospital entre outubro de 2018 e janeiro de 2019. Os dados foram registrados e armazenados em banco de dados, em seguida foi realizada análise descritiva no GraphPad Programa Prisma 6.0. As variáveis quantitativas foram expressas como desvio padrão (DP) da média e o número de casos como percentual. O estudo foi realizado com 70 pacientes que estavam internados no hospital e necessitaram utilizar algum dos antimicrobianos selecionados no período de observação durante o tratamento hospitalar. Os pacientes acompanhados no estudo eram em sua maioria do sexo masculino (64,29%; n = 45). A idade variou de 19 a 96 anos, com média de 52,49 anos (DP = 20,31). Os pacientes incluídos eram em sua maioria oriundos do ambulatório de oncologia (34,29%; n = 24) e aqueles que haviam sido operados (27,14%; n = 19). A maioria dos pacientes críticos internados na UTI adulto (26,47%; n = 9) desenvolveu LRA. Em relação ao número de medicamentos utilizados pelos pacientes, houve variação de 5 a 17, com média de 10,26 (DP = 2,90) medicamentos prescritos por paciente. Nos dados referentes aos antimicrobianos, a maioria dos pacientes fazia uso de ceftriaxona (n = 29), cefepima (n = 27) e piperacilina/tazobactam (n = 23). Em termos do número de antimicrobianos prescritos por paciente, 60% (n = 42) dos pacientes tomaram apenas um, 30% (n = 21) tomaram dois e 10% (n = 7) tomaram três ou mais antimicrobianos para tratamento de infecções. Durante o período do estudo, as concentrações plasmáticas de vancomicina variaram de 3,0 μg/mL a 22,5 μg/mL. Das 10 amostras coletadas, 10,0% (n = 1) estavam acima da faixa terapêutica estabelecida pela literatura (entre 10 a 20 µg/mL), 30,0% (n = 3) estavam dentro dos valores de referência e 60,0% (n = 6) dos pacientes apresentaram valores abaixo dos valores de referência. Os pacientes que desenvolveram LRA (60,0%; n = 6) durante o uso de vancomicina apresentaram valores de concentração entre 3 µg/mL e 15,9 µg/mL, sendo que a maioria apresentou valores abaixo da faixa terapêutica recomendada. Desses pacientes com LRA, 83,33% (n = 5) utilizaram mais de um antimicrobiano nefrotóxico durante o tratamento hospitalar. As concentrações de pacientes que não foram diagnosticados com LRA (40,0%; n = 4) variaram de 3,0 µg/mL a 22,5 µg/mL.
DOI: 10.17632/s58z23mvpw.3
title: RESULTADO DE DADOS ANTIMICROBIANO E OCORRÊNCIA DE LESÃO RENAL AGUDA EM PACIENTES INTERNADOS EM UM HOSPITAL NO OESTE DO PARÁ, BRASIL.

description: Nas unidades hospitalares, a avaliação e o acompanhamento farmacêutico das prescrições médicas constituem uma importante fonte de assistência farmacêutica. Um problema comum e que apresenta altas taxas de incidência hospitalar é a ocorrência de lesão renal aguda (LRA). A farmacovigilância é implementada em hospitais com a finalidade de monitorar relatos de efeitos adversos relacionados aos medicamentos administrados aos pacientes. O objetivo do estudo é avaliar a incidência de LRA em pacientes internados e expostos a antimicrobianos em um hospital público do estado do Pará, Brasil. Foi realizado um estudo de coorte prospectivo e observacional, cujo desfecho de interesse é a ocorrência de LRA em pacientes internados no hospital entre outubro de 2018 e janeiro de 2019. Os dados foram registrados e armazenados em banco de dados, em seguida foi realizada análise descritiva no GraphPad Programa Prisma 6.0. As variáveis quantitativas foram expressas como desvio padrão (DP) da média e o número de casos como percentual. O estudo foi realizado com 70 pacientes que estavam internados no hospital e necessitaram utilizar algum dos antimicrobianos selecionados no período de observação durante o tratamento hospitalar. Os pacientes acompanhados no estudo eram em sua maioria do sexo masculino (64,29%; n = 45). A idade variou de 19 a 96 anos, com média de 52,49 anos (DP = 20,31). Os pacientes incluídos eram em sua maioria oriundos do ambulatório de oncologia (34,29%; n = 24) e aqueles que haviam sido operados (27,14%; n = 19). A maioria dos pacientes críticos internados na UTI adulto (26,47%; n = 9) desenvolveu LRA. Em relação ao número de medicamentos utilizados pelos pacientes, houve variação de 5 a 17, com média de 10,26 (DP = 2,90) medicamentos prescritos por paciente. Nos dados referentes aos antimicrobianos, a maioria dos pacientes fazia uso de ceftriaxona (n = 29), cefepima (n = 27) e piperacilina/tazobactam (n = 23). Em termos do número de antimicrobianos prescritos por paciente, 60% (n = 42) dos pacientes tomaram apenas um, 30% (n = 21) tomaram dois e 10% (n = 7) tomaram três ou mais antimicrobianos para tratamento de infecções. Durante o período do estudo, as concentrações plasmáticas de vancomicina variaram de 3,0 μg/mL a 22,5 μg/mL. Das 10 amostras coletadas, 10,0% (n = 1) estavam acima da faixa terapêutica estabelecida pela literatura (entre 10 a 20 µg/mL), 30,0% (n = 3) estavam dentro dos valores de referência e 60,0% (n = 6) dos pacientes apresentaram valores abaixo dos valores de referência. Os pacientes que desenvolveram LRA (60,0%; n = 6) durante o uso de vancomicina apresentaram valores de concentração entre 3 µg/mL e 15,9 µg/mL, sendo que a maioria apresentou valores abaixo da faixa terapêutica recomendada. Desses pacientes com LRA, 83,33% (n = 5) utilizaram mais de um antimicrobiano nefrotóxico durante o tratamento hospitalar. As concentrações de pacientes que não foram diagnosticados com LRA (40,0%; n = 4) variaram de 3,0 µg/mL a 22,5 µg/mL.
DOI: 10.17632/p8d3xyvfnp.1
title: Cross-cultural adaptation and preliminary analysis of the measurement properties of the Telehealth Usability Questionnaire for the Brazilian population (TUQ Brazil)

description: The study aimed to translate and cross-culturally adapt into Brazilian Portuguese the Telehealth Usability Questionnaire (TUQ) and to evaluate preliminary indicators of its reliability and validity when applied to this population.
This dataset describes and documents the process of translation and cross-cultural adaptation that included five steps as follows: (1) initial translations: translation of the instrument from English as a source language to the target language, Brazilian Portuguese. Two translations from English into Brazilian Portuguese were generated independently by two native-speakers translators of Brazilian Portuguese - documents Translation 1 (T1).docx and Translation 2 (T2).docx; (2) Synthesis of translations: a synthesis of the translated versions into Brazilian Portuguese were discussed by the two translators, the researchers and the study coordinator. A single translated version was created – document Synthesis of translation (ST).docx; (3) Reverse translations: reverse translations of the Synthesis of translation from Brazilian Portuguese to English were performed by two native-speakers translators of English who created the back-translated versions BT1 and BT2 – documents Back-translation 1 (BT1).docx and  Back-translation 2 (BT2).docx; (4) expert committee evaluation: a committee of experts was invited to consolidate the previous versions of the questionnaire and to develop a pre-final version of the questionnaire in Brazilian Portuguese – document Pre-final version.docx; (5) evaluation of the pre-final version: fifty-four individuals from the target population responded in a self-administered manner the pre-final version of the TUQ-Brazil questionnaire, and their comprehension and answer of each item of the questionnaire were assessed and described in the Methods section of the manuscript. 
A culturally adapted version of the TUQ for the Brazilian population was documented following cross-cultural adaptations, expert committee recommendations, and the pre-final version test results.
DOI: 10.17632/p8d3xyvfnp.2
title: Cross-cultural adaptation and analysis of the measurement properties of the Telehealth Usability Questionnaire for the Brazilian population (TUQ Brazil)

description: The study aimed to translate and cross-culturally adapt into Brazilian Portuguese the Telehealth Usability Questionnaire (TUQ) and to evaluate its reliability and validity when applied to this population.
This dataset describes and documents the process of translation and cross-cultural adaptation that included five steps as follows: (1) initial translations: translation of the instrument from English as a source language to the target language, Brazilian Portuguese. Two translations from English into Brazilian Portuguese were generated independently by two native-speakers translators of Brazilian Portuguese - documents Translation 1 (T1).docx and Translation 2 (T2).docx; (2) Synthesis of translations: a synthesis of the translated versions into Brazilian Portuguese were discussed by the two translators, the researchers and the study coordinator. A single translated version was created – document Synthesis of translation (ST).docx; (3) Reverse translations: reverse translations of the Synthesis of translation from Brazilian Portuguese to English were performed by two native-speakers translators of English who created the back-translated versions BT1 and BT2 – documents Back-translation 1 (BT1).docx and  Back-translation 2 (BT2).docx; (4) expert committee evaluation: a committee of experts was invited to consolidate the previous versions of the questionnaire and to develop a pre-final version of the questionnaire in Brazilian Portuguese – document Pre-final version.docx; (5) evaluation of the pre-final version: fifty-four individuals from the target population responded in a self-administered manner the pre-final version of the TUQ-Brazil questionnaire, and their comprehension and answer of each item of the questionnaire were assessed and described in the Methods section of the manuscript. 
A culturally adapted version of the TUQ for the Brazilian population was documented following cross-cultural adaptations, expert committee recommendations, and the final version test results.
DOI: 10.17632/p8d3xyvfnp.3
title: Cross-cultural adaptation and analysis of the measurement properties of the Telehealth Usability Questionnaire for the Brazilian population (TUQ Brazil)

description:  The study aimed to translate and cross-culturally adapt into Brazilian Portuguese the Telehealth Usability Questionnaire (TUQ) and to evaluate its reliability and validity when applied to this population.
This dataset describes and documents the process of translation and cross-cultural adaptation that included five steps as follows: (1) initial translations: translation of the instrument from English as a source language to the target language, Brazilian Portuguese. Two translations from English into Brazilian Portuguese were generated independently by two native-speakers translators of Brazilian Portuguese - documents Translation 1 (T1).docx and Translation 2 (T2).docx; (2) Synthesis of translations: a synthesis of the translated versions into Brazilian Portuguese were discussed by the two translators, the researchers and the study coordinator. A single translated version was created – document Synthesis of translation (ST).docx; (3) Reverse translations: reverse translations of the Synthesis of translation from Brazilian Portuguese to English were performed by two native-speakers translators of English who created the back-translated versions BT1 and BT2 – documents Back-translation 1 (BT1).docx and  Back-translation 2 (BT2).docx; (4) expert committee evaluation: a committee of experts was invited to consolidate the previous versions of the questionnaire and to develop a pre-final version of the questionnaire in Brazilian Portuguese – document Pre-final version.docx; (5) evaluation of the pre-final version: fifty-four individuals from the target population responded in a self-administered manner the pre-final version of the TUQ-Brazil questionnaire, and their comprehension and answer of each item of the questionnaire were assessed and described in the Methods section of the manuscript. 
A culturally adapted version of the TUQ for the Brazilian population was documented following cross-cultural adaptations, expert committee recommendations, and the final version test results.