DOI: 10.26180/21259491
title: Raw data outputs 1-18

description: Raw data outputs 1-18 <strong>Raw data output 1.</strong> Differentially expressed genes in AML CSCs compared with GTCs as well as in TCGA AML cancer samples compared with normal ones. This data was generated based on the results of AML microarray and TCGA data analysis. <strong>Raw data output 2.</strong> Commonly and uniquely differentially expressed genes in AML CSC/GTC microarray and TCGA bulk RNA-seq datasets. This data was generated based on the results of AML microarray and TCGA data analysis. <strong>Raw data output 3.</strong> Common differentially expressed genes between training and test set samples the microarray dataset. This data was generated based on the results of AML microarray data analysis. <strong>Raw data output 4.</strong> Detailed information on the samples of the breast cancer microarray dataset (GSE52327) used in this study. <strong>Raw data output 5.</strong> Differentially expressed genes in breast CSCs compared with GTCs as well as in TCGA BRCA cancer samples compared with normal ones. <strong>Raw data output 6.</strong> Commonly and uniquely differentially expressed genes in breast cancer CSC/GTC microarray and TCGA BRCA bulk RNA-seq datasets. This data was generated based on the results of breast cancer microarray and TCGA BRCA data analysis. CSC, and GTC are abbreviations of cancer stem cell, and general tumor cell, respectively. <strong>Raw data output 7.</strong> Differential and common co-expression and protein-protein interaction of genes between CSC and GTC samples. This data was generated based on the results of AML microarray and STRING database-based protein-protein interaction data analysis. CSC, and GTC are abbreviations of cancer stem cell, and general tumor cell, respectively. <strong>Raw data output 8.</strong> Differentially expressed genes between AML dormant and active CSCs. This data was generated based on the results of AML scRNA-seq data analysis. <strong>Raw data output 9.</strong> Uniquely expressed genes in dormant or active AML CSCs. This data was generated based on the results of AML scRNA-seq data analysis. <strong>Raw data output 10.</strong> Intersections between the targeting transcription factors of AML key CSC genes and differentially expressed genes between AML CSCs vs GTCs and between dormant and active AML CSCs or the uniquely expressed genes in either class of CSCs. <strong>Raw data output 11.</strong> Targeting desirableness score of AML key CSC genes and their targeting transcription factors. These scores were generated based on an in-house scoring function described in the Methods section. <strong>Raw data output 12.</strong> CSC-specific targeting desirableness score of AML key CSC genes and their targeting transcription factors. These scores were generated based on an in-house scoring function described in the Methods section. <strong>Raw data output 13.</strong> The protein-protein interactions between AML key CSC genes with themselves and their targeting transcription factors. This data was generated based on the results of AML microarray and STRING database-based protein-protein interaction data analysis. <strong>Raw data output 14.</strong> The previously confirmed associations of genes having the highest targeting desirableness and CSC-specific targeting desirableness scores with AML or other cancers’ (stem) cells as well as hematopoietic stem cells. These data were generated based on a PubMed database-based literature mining. <strong>Raw data output 15.</strong> Drug score of available drugs and bioactive small molecules targeting AML key CSC genes and/or their targeting transcription factors. These scores were generated based on an in-house scoring function described in the Methods section. <strong>Raw data output 16.</strong> CSC-specific drug score of available drugs and bioactive small molecules targeting AML key CSC genes and/or their targeting transcription factors. These scores were generated based on an in-house scoring function described in the Methods section. <strong>Raw data output 17.</strong> Candidate drugs for experimental validation. These drugs were selected based on their respective (CSC-specific) drug scores. CSC is the abbreviation of cancer stem cell. <strong>Raw data output 18.</strong> Detailed information on the samples of the AML microarray dataset GSE30375 used in this study.