cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.14266596
title: Additional file 2 of A non-invasive nanoparticles for multimodal imaging of ischemic myocardium in rats

description: Additional file 2: Movie S1. Echocardiography before operation in rats. Movie S2. Echocardiography after operation in model rats.
DOI: 10.6084/m9.figshare.20037441
title: The activity time of the lesser bamboo bat, Tylonycteris pachypus (Chiroptera: Vespertilionidae)

description: The activity time of the lesser bamboo bat, Tylonycteris pachypus (Temminck, 1840), was investigated at two observation locations in southern China: Longzhou and Guiping. Two bouts of activity (post dusk and predawn), with an intervening period of night roosting at diurnal roosts, were identified. The period of activity within each bout was usually less than 30 minutes. The activity periods of individuals belonging to the Longzhou population right after dusk and just before dawn lasted longer than those of the the Guiping population. We also found that the nocturnal emergence time of T. pachypus from the Longzhou population happened earlier than in the Guiping population. These findings indicate that the activity time of T. pachypus was quite short at night, and that different locations may affect the nocturnal activity rhythm of this species.
DOI: 10.6084/m9.figshare.21610396.v1
title: Macrophage-derived exosomes regulate gastric cancer cell oxaliplatin resistance by wrapping circ 0008253

description: Oxaliplatin (OXA) is a first-line chemotherapy drug for gastric cancer. We aimed to investigate the effect of circ 0008253, contained in M2 polarized macrophage-derived exosomes, on OXA resistance of gastric carcinoma cells. Flow cytometry was performed to detect the differentiation of macrophages and cell apoptosis. Cell Counting Kit-8 assay was conducted to examine the cell viability. Transmission electron microscopy, Nanoparticle Tracking Analysis, Western bolt, and Immunofluorescence were carried out. Cell proliferation was detected with a colony formation experiment. Levels of CD206, Arg1, IL-10, and TGF-β were increased in M2 polarized macrophages. Cell viability was decreased gradually with the increase of time and OXA concentration. Apoptosis of gastric carcinoma cells was decreased after co-culture with M2-polarized macrophages. Exosomes isolated from M2-polarized macrophages (M2-Exos) could be co-located with gastric carcinoma cells. M2-Exos enhanced drug resistance, reduced apoptosis and OXA resistance. Bioinformatics analysis showed that circ 0008253 could be transferred from M2-Exos to gastric carcinoma cells. Overexpressing circ 0008253 increased cell viability, tumor size, and ABCG2 levels, decreased OXA sensitivity. Circ 0008253, contained in M2-Exos, was directly transferred from tumor-associated macrophage to gastric carcinoma cells, finally enhancing OXA resistance.
DOI: 10.6084/m9.figshare.20033196
title: Additional file 4 of Comprehensive identification and characterization of the HERV-K (HML-9) group in the human genome

description: Additional file 4: Table S2. HML-9 solo LTR sequences colocalized with genes.
DOI: 10.6084/m9.figshare.20033196.v1
title: Additional file 4 of Comprehensive identification and characterization of the HERV-K (HML-9) group in the human genome

description: Additional file 4: Table S2. HML-9 solo LTR sequences colocalized with genes.
DOI: 10.6084/m9.figshare.20033208
title: Additional file 6 of Comprehensive identification and characterization of the HERV-K (HML-9) group in the human genome

description: Additional file 6: Table S4. The associations between each proviral LTR and its putative regulated gene(s).
DOI: 10.6084/m9.figshare.22655342.v1
title: Additional file 1 of FACI is a novel clathrin adaptor protein 2-binding protein that facilitates low-density lipoprotein endocytosis

description: Additional file 1: Table S1. Lists of reagents, plasmids, antibodies, and oligonucleotides.
DOI: 10.6084/m9.figshare.14270044.v1
title: Dynamic changes of periostin and collagen I in the sclera during progressive myopia in guinea pigs

description: ABSTRACT Purpose: To investigate periostin and collagen I expression during a scleral remodeling in myopic eyes and to determine their role in collagen remodeling of the myopic sclera. Methods: Fifty one-week-old guinea pigs were divided into the control and form-deprivation myopia (FDM) groups. The eyes of animals in the form-deprivation myopia group were covered for 2, 4, and 8 weeks, or were covered for 4 weeks and then uncovered for 2 weeks. The diopters and axial lengths in the eyes in each group of guinea pigs were measured. Immunohistochemistry and reverse transcription polymerase chain reaction were used to detect the relative protein and mRNA expressions of periostin and collagen I in the scleral tissues of guinea pig. Results: Before masking, guinea pigs in the control and form-deprivation myopia groups were hypermetropic and did not differ significantly (p&gt;0.05). Hypermetropic refraction in the control group gradually decreased. In guinea pigs from the form-deprivation myopia group, the refractive power gradually changed from +2.14 ± 0.33 D to -7.22 ± 0.51 D, and the axial length gradually changed from 5.92 ± 0.37 mm to 8.05 ± 0.34 mm from before until the end of masking. Before covering, no significant difference was observed in the relative collagen I and periostin mRNA and protein expression levels in the sclera of the guinea pig control and form-deprivation myopia groups (p&gt;0.05). The relative collagen I and periostin protein and mRNA expression levels in the sclera of guinea pigs in the form-deprivation myopia group at 2, 4, and 8 weeks, and after covering the eyes for 4 weeks followed by uncovering for 2 weeks, were significantly lower than those in the control group (p&lt;0.05). The collagen I and periostin mRNA expression levels were positively correlated with protein expression levels in the sclera of guinea pigs (protein: r=0.936, p&lt;0.05; mRNA: r=0.909, p&lt;0.05). Conclusions: Periostin was expressed in the myopic sclera of guinea pigs, and changes in periostin and collagen I expression were highly consistent. Periostin and collagen I may be involved in the regulation of scleral remodeling in myopia.
DOI: 10.6084/m9.figshare.20037705
title: A review of Neoproterozoic to early Palaeozoic rocks of the Jiamusi–Khanka Massif, NE China: a rifted fragment from the Siberian Craton?

description: The tectonic setting of the Jiamusi–Khanka Massif in the eastern sector of the Central Asian Orogenic Belt (CAOB) in NE China is still highly controversial. This review considers all existing data to evaluate the origin of the Jiamusi–Khanka Massif. The Precambrian basement in the Jiamusi–Khanka Massif is dominated by the Neoproterozoic orthogneisses (898–891 and 757–751 Ma), the Mashan Complex (peak metamorphism at 530–500 Ma), and syntectonically deformed early Palaeozoic granitoids (530–484 Ma) related to the metamorphism of the Mashan Complex. The Mashan Complex reveals a clockwise orogen-style <i>P–T</i> path with peak conditions of 850–870°C/8–9 kbar followed by isothermal decompression. It was intruded by syn- (530–500 Ma) and post-tectonic (490–476 Ma) granitic rocks. The Jiamusi–Khanka Massif cannot be directly derived from the North China, South China, or Tarim cratons. Instead, it may have originated in the Siberian Craton and formed once part of the Altai-Sayan and Baikal orogens at ~500 Ma. For the Jiamusi Massif, we developed a plate tectonic model, and relate the final granulite facies metamorphism to slab break-off after consumption of a branch of the Palaeo-Asian Ocean.
DOI: 10.6084/m9.figshare.14269912.v1
title: Jingzhaotoxin-X, a gating modifier of Kv4.2 and Kv4.3 potassium channels purified from the venom of the Chinese tarantula Chilobrachys jingzhao

description: Abstract Background: The tarantula Chilobrachys jingzhao is one of the largest venomous spiders in China. In previous studies, we purified and characterized at least eight peptides from C. jingzhao venom. In this report, we describe the purification and characterization of Jingzhaotoxin-X (JZTX-X), which selectively blocks Kv4.2 and Kv4.3 potassium channels. Methods: JZTX-X was purified using a combination of cation-exchange HPLC and reverse-phase HPLC. The amino-acid sequence was determined by automated Edman degradation and confirmed by mass spectrometry (MS). Voltage-gated ion channel currents were recorded in HEK293t cells transiently transfected with a variety of ion channel constructs. In addition, the hyperalgesic activity of JZTX-X and the toxin´s effect on motor function were assessed in mice. Results: JZTX-X contained 31 amino acids, with six cysteine residues that formed three disulfide bonds within an inhibitory cysteine knot (ICK) topology. In whole-cell voltage-clamp experiments, JZTX-X inhibited Kv4.2 and Kv4.3 potassium channels in a concentration- and voltage-dependent manner, without affecting other ion channels (Kv1.1, 1.2, 1.3, 2.1, delayed rectifier potassium channels, high- and low-voltage-activated Ca2+ channels, and voltage-gated sodium channels Nav1.5 and 1.7). JZTX-X also shifted the voltage-dependent channel activation to more depolarized potentials, whereas extreme depolarization caused reversible toxin binding to Kv4.2 channels. JZTX-X shifted the Kv4.2 and Kv4.3 activities towards a resting state, since at the resting potential the toxin completely inhibited the channels, even in the absence of an applied physical stimulus. Intrathecal or intraplantar injection of JZTX-X caused a long-lasting decrease in the mechanical nociceptive threshold (hyperalgesia) but had no effect on motor function as assessed in the rotarod test. Conclusions: JZTX-X selectively suppresses Kv4.2 and Kv4.3 potassium channel activity in a concentration- and voltage-dependent manner and causes long-lasting mechanical hyperalgesia.
DOI: 10.6084/m9.figshare.20037441.v1
title: The activity time of the lesser bamboo bat, Tylonycteris pachypus (Chiroptera: Vespertilionidae)

description: The activity time of the lesser bamboo bat, Tylonycteris pachypus (Temminck, 1840), was investigated at two observation locations in southern China: Longzhou and Guiping. Two bouts of activity (post dusk and predawn), with an intervening period of night roosting at diurnal roosts, were identified. The period of activity within each bout was usually less than 30 minutes. The activity periods of individuals belonging to the Longzhou population right after dusk and just before dawn lasted longer than those of the the Guiping population. We also found that the nocturnal emergence time of T. pachypus from the Longzhou population happened earlier than in the Guiping population. These findings indicate that the activity time of T. pachypus was quite short at night, and that different locations may affect the nocturnal activity rhythm of this species.
DOI: 10.25549/usctheses-ouc11668763
title: Microsoft Word - title.docx
DOI: 10.6084/m9.figshare.22655345.v1
title: Additional file 2 of FACI is a novel clathrin adaptor protein 2-binding protein that facilitates low-density lipoprotein endocytosis

description: Additional file 2: Table S2. BioID-mass spectrometric data. Lists of potential FACI-interacting proteins in AML12 identified with the BioID approach.
DOI: 10.6084/m9.figshare.22655348
title: Additional file 3 of FACI is a novel clathrin adaptor protein 2-binding protein that facilitates low-density lipoprotein endocytosis

description: Additional file 3: Table S3. Affinity purification-mass spectrometric data. Lists of potential FACI-interacting proteins in AML12 identified with affinity purification approach.
DOI: 10.25549/usctheses-ouc11668766
title: Reducing Barriers Influencing Women Entrepreneurs in Community College
DOI: 10.6084/m9.figshare.22655348.v1
title: Additional file 3 of FACI is a novel clathrin adaptor protein 2-binding protein that facilitates low-density lipoprotein endocytosis

description: Additional file 3: Table S3. Affinity purification-mass spectrometric data. Lists of potential FACI-interacting proteins in AML12 identified with affinity purification approach.
DOI: 10.6084/m9.figshare.5357833
title: Spatial-temporal relationships of late Mesozoic granitoids in Zhejiang Province, Southeast China: constraints on tectonic evolution

description: Late Mesozoic granitoids in South China are generally considered to have been generated under the Palaeo–Pacific tectonic regime, however, the precise subduction mechanism remains controversial. Detailed zircon U–Pb geochronological, major and trace element, and Sr–Nd–Hf isotopic data are used to document the spatiotemporal distribution of the granitoids in Zhejiang Province. Three periods of late Mesozoic magmatism, including stage 1 (170–145 Ma), stage 2 (145–125 Ma), and stage 3 (125–90 Ma), can be distinguished based on systematic zircon U–Pb ages that become progressively younger towards the SE. Stage 1 granitic rocks are predominantly I-type granitoids, but minor S- or A-type rocks also occur. Sr–Nd–Hf isotopic data suggest that these granitoids were generated from hybrid magmas that resulted from mixing between depleted mantle-derived and ancient crust-derived magmas that formed in an active continental margin environment related to the low-angle subduction of the Palaeo–Pacific plate beneath Southeast China mainland. Stage 2 granitic rocks along the Jiangshan–Shaoxing Fault are predominantly I- and A-type granitoids with high initial <sup>87</sup>Sr/<sup>86</sup>Sr, low <i>ε</i><sub>Nd</sub>(<i>t</i>), <i>ε</i><sub>Hf</sub>(<i>t</i>) values and Mesoproterozoic Nd–Hf model ages. These results suggest that stage 2 granitoids were derived from mixing between enriched mantle-derived mafic magmas and ancient crust-derived magmas in an extensional back-arc setting related to rollback of the Palaeo–Pacific slab. Stage 3 granitic rocks along the Lishui–Yuyao Fault comprise mainly A- and I-type granitoids with high initial <sup>87</sup>Sr/<sup>86</sup>Sr ratios, and low <i>ε</i><sub>Nd</sub>(<i>t</i>) and <i>ε</i><sub>Hf</sub>(<i>t</i>) values, again suggesting mixing of enriched mantle-derived mafic magmas with more ancient crustal magmas in an extensional back-arc setting, related in this case to the continued rollback the Palaeo–Pacific plate and the outboard retreat of its subduction zone.
DOI: 10.6084/m9.figshare.19519327
title: Circ_0007841 knockdown confers cisplatin sensitivity to ovarian cancer cells by down-regulation of NFIB expression in a miR-532-5p-dependent manner

description: Cisplatin (DDP) is first-line management for ovarian cancer (OC). Previous data have suggested that circular RNA_0007841 (circ_0007841) regulates OC progression; however, there is no data on its role in the sensitivity of OC cells to DDP. RNA expression of circ_0007841, microRNA-532-5p (miR-532-5p) and nuclear factor I B (NFIB) was detected by quantitative real-time polymerase chain reaction in OC patient samples and OC cell lines. Protein expression was checked by Western blotting analysis. Cell viability, proliferation, cell apoptotic rate, migration and invasion were investigated by 3-(4,5)-dimethylthiahiazo (-z-y1)-3,5-diphenytetrazoliumromide, 5-Ethynyl-29-deoxyuridine, flow cytometry analysis, scratch test and transwell assays, respectively. The interactions among circ_0007841, miR-532-5p and NFIB were identified by a dual-luciferase reporter assay. Xenograft mouse model assay was performed to determine the effect of circ_0007841 on DDP sensitivity in vivo. Circ_0007841 and NFIB expression were upregulated, whereas miR-532-5p was downregulated in DDP-resistant OC tissues and cells compared with controls. Circ_0007841 silencing improved DDP sensitivity, inhibited cell proliferation, invasion and migration, but induced cell apoptosis in DDP-resistant OC cells. Circ_0007841 acted as a miR-532-5p sponge and regulated DDP resistance and OC cell malignancy through miR-532-5p in DDP-resistant OC cells. Besides, the overexpression of NFIB, a target of miR-532-5p, remitted miR-532-5p-mediated effects in DDP-resistant OC cells. Circ_0007841 depletion conferred DDP sensitivity to DDP-resistant OC cells in vivo. Further, circ_0007841 was secreted from DDP-resistant OC cells through being packaged into exosomes. Circ_0007841 conferred DDP resistance to DDP-resistant OC cells through the miR-532-5p/NFIB axis, suggesting the potential of circ_0007841 as a therapeutic target for OC.
DOI: 10.6084/m9.figshare.19519327.v1
title: Circ_0007841 knockdown confers cisplatin sensitivity to ovarian cancer cells by down-regulation of NFIB expression in a miR-532-5p-dependent manner

description: Cisplatin (DDP) is first-line management for ovarian cancer (OC). Previous data have suggested that circular RNA_0007841 (circ_0007841) regulates OC progression; however, there is no data on its role in the sensitivity of OC cells to DDP. RNA expression of circ_0007841, microRNA-532-5p (miR-532-5p) and nuclear factor I B (NFIB) was detected by quantitative real-time polymerase chain reaction in OC patient samples and OC cell lines. Protein expression was checked by Western blotting analysis. Cell viability, proliferation, cell apoptotic rate, migration and invasion were investigated by 3-(4,5)-dimethylthiahiazo (-z-y1)-3,5-diphenytetrazoliumromide, 5-Ethynyl-29-deoxyuridine, flow cytometry analysis, scratch test and transwell assays, respectively. The interactions among circ_0007841, miR-532-5p and NFIB were identified by a dual-luciferase reporter assay. Xenograft mouse model assay was performed to determine the effect of circ_0007841 on DDP sensitivity in vivo. Circ_0007841 and NFIB expression were upregulated, whereas miR-532-5p was downregulated in DDP-resistant OC tissues and cells compared with controls. Circ_0007841 silencing improved DDP sensitivity, inhibited cell proliferation, invasion and migration, but induced cell apoptosis in DDP-resistant OC cells. Circ_0007841 acted as a miR-532-5p sponge and regulated DDP resistance and OC cell malignancy through miR-532-5p in DDP-resistant OC cells. Besides, the overexpression of NFIB, a target of miR-532-5p, remitted miR-532-5p-mediated effects in DDP-resistant OC cells. Circ_0007841 depletion conferred DDP sensitivity to DDP-resistant OC cells in vivo. Further, circ_0007841 was secreted from DDP-resistant OC cells through being packaged into exosomes. Circ_0007841 conferred DDP resistance to DDP-resistant OC cells through the miR-532-5p/NFIB axis, suggesting the potential of circ_0007841 as a therapeutic target for OC.
DOI: 10.6084/m9.figshare.21610396
title: Macrophage-derived exosomes regulate gastric cancer cell oxaliplatin resistance by wrapping circ 0008253

description: Oxaliplatin (OXA) is a first-line chemotherapy drug for gastric cancer. We aimed to investigate the effect of circ 0008253, contained in M2 polarized macrophage-derived exosomes, on OXA resistance of gastric carcinoma cells. Flow cytometry was performed to detect the differentiation of macrophages and cell apoptosis. Cell Counting Kit-8 assay was conducted to examine the cell viability. Transmission electron microscopy, Nanoparticle Tracking Analysis, Western bolt, and Immunofluorescence were carried out. Cell proliferation was detected with a colony formation experiment. Levels of CD206, Arg1, IL-10, and TGF-β were increased in M2 polarized macrophages. Cell viability was decreased gradually with the increase of time and OXA concentration. Apoptosis of gastric carcinoma cells was decreased after co-culture with M2-polarized macrophages. Exosomes isolated from M2-polarized macrophages (M2-Exos) could be co-located with gastric carcinoma cells. M2-Exos enhanced drug resistance, reduced apoptosis and OXA resistance. Bioinformatics analysis showed that circ 0008253 could be transferred from M2-Exos to gastric carcinoma cells. Overexpressing circ 0008253 increased cell viability, tumor size, and ABCG2 levels, decreased OXA sensitivity. Circ 0008253, contained in M2-Exos, was directly transferred from tumor-associated macrophage to gastric carcinoma cells, finally enhancing OXA resistance.
DOI: 10.6084/m9.figshare.23707003.v1
title: Additional file 4 of Potential prognostic and therapeutic value of ANXA8 in renal cell carcinoma: based on the comprehensive analysis of annexins family

description: Supplementary Material 4
DOI: 10.6084/m9.figshare.20037705.v1
title: A review of Neoproterozoic to early Palaeozoic rocks of the Jiamusi–Khanka Massif, NE China: a rifted fragment from the Siberian Craton?

description: The tectonic setting of the Jiamusi–Khanka Massif in the eastern sector of the Central Asian Orogenic Belt (CAOB) in NE China is still highly controversial. This review considers all existing data to evaluate the origin of the Jiamusi–Khanka Massif. The Precambrian basement in the Jiamusi–Khanka Massif is dominated by the Neoproterozoic orthogneisses (898–891 and 757–751 Ma), the Mashan Complex (peak metamorphism at 530–500 Ma), and syntectonically deformed early Palaeozoic granitoids (530–484 Ma) related to the metamorphism of the Mashan Complex. The Mashan Complex reveals a clockwise orogen-style <i>P–T</i> path with peak conditions of 850–870°C/8–9 kbar followed by isothermal decompression. It was intruded by syn- (530–500 Ma) and post-tectonic (490–476 Ma) granitic rocks. The Jiamusi–Khanka Massif cannot be directly derived from the North China, South China, or Tarim cratons. Instead, it may have originated in the Siberian Craton and formed once part of the Altai-Sayan and Baikal orogens at ~500 Ma. For the Jiamusi Massif, we developed a plate tectonic model, and relate the final granulite facies metamorphism to slab break-off after consumption of a branch of the Palaeo-Asian Ocean.
DOI: 10.6084/m9.figshare.23706997.v1
title: Additional file 2 of Potential prognostic and therapeutic value of ANXA8 in renal cell carcinoma: based on the comprehensive analysis of annexins family

description: Supplementary Material 2
DOI: 10.6084/m9.figshare.20037471.v1
title: Evolution of erythrocyte morphology in amphibians (Amphibia: Anura)

description: ABSTRACT We compared the morphology of the erythrocytes of five anurans, two toad species - Bufo gargarizans (Cantor, 1842) and Duttaphrynus melanostictus (Schneider, 1799) and three frog species - Fejervarya limnocharis (Gravenhorst, 1829), Microhyla ornata (Duméril & Bibron, 1841), and Rana zhenhaiensis (Ye, Fei & Matsui, 1995). We then reconstructed the ancestral state of erythrocyte size (ES) and nuclear size (NS) in amphibians based on a molecular tree. Nine morphological traits of erythrocytes were all significantly different among the five species. The results of principal component analysis showed that the first component (49.1% of variance explained) had a high positive loading for erythrocyte length, nuclear length, NS and ratio of erythrocyte length/erythrocyte width; the second axis (28.5% of variance explained) mainly represented erythrocyte width and ES. Phylogenetic generalized least squares analysis showed that the relationship between NS and ES was not affected by phylogenetic relationships although there was a significant linear relationship between these two variables. These results suggested that (1) the nine morphological traits of erythrocytes in the five anuran species were species-specific; (2) in amphibians, larger erythrocytes generally had larger nuclei.