cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.28517147.v1
title: Additional file 9 of CTCF is selectively required for maintaining chromatin accessibility and gene expression in human erythropoiesis

description: Additional file 9: Table S8. Hi-C datasets, and annotated TADs and chromatin loops information in CTCF-AID HEL cells with IAA treatment vs. without IAA treatment grown in culture under no hemin treated conditions for 24 hours.
DOI: 10.6084/m9.figshare.28517150
title: Additional file 10 of CTCF is selectively required for maintaining chromatin accessibility and gene expression in human erythropoiesis

description: Additional file 10: Table S9. CTCF direct target genes from ATAC-seq and RNA-seq integrative analysis.
DOI: 10.6084/m9.figshare.28517150.v1
title: Additional file 10 of CTCF is selectively required for maintaining chromatin accessibility and gene expression in human erythropoiesis

description: Additional file 10: Table S9. CTCF direct target genes from ATAC-seq and RNA-seq integrative analysis.
DOI: 10.6084/m9.figshare.28517153
title: Additional file 11 of CTCF is selectively required for maintaining chromatin accessibility and gene expression in human erythropoiesis

description: Additional file 11: Table S10. Gene Ontology analysis, and Transcription factors occupancy analysis for the CTCF direct target genes from ATAC-seq and RNA-seq integrative analysis.
DOI: 10.6084/m9.figshare.28517156
title: Additional file 12 of CTCF is selectively required for maintaining chromatin accessibility and gene expression in human erythropoiesis

description: Additional file 12: Table S11. GATA1 ChIP-seq peaks before and after IAA treatment before and after IAA treatment in both HUDEP-2 and HEL cells in the immature state.
DOI: 10.6084/m9.figshare.28517156.v1
title: Additional file 12 of CTCF is selectively required for maintaining chromatin accessibility and gene expression in human erythropoiesis

description: Additional file 12: Table S11. GATA1 ChIP-seq peaks before and after IAA treatment before and after IAA treatment in both HUDEP-2 and HEL cells in the immature state.
DOI: 10.6084/m9.figshare.28517162
title: Additional file 13 of CTCF is selectively required for maintaining chromatin accessibility and gene expression in human erythropoiesis

description: Additional file 13: Table S12. Oligonucleotides, DNA primers, and antibodies used in this study. Oligonucleotides were used for sgRNA vector construction; DNA primers were used to analyze Cas9-mediated indels by Sanger sequencing; antibodies were used for Western blotting, immunoprecipitation, or ChIP-seq analysis.
DOI: 10.6084/m9.figshare.28517162.v1
title: Additional file 13 of CTCF is selectively required for maintaining chromatin accessibility and gene expression in human erythropoiesis

description: Additional file 13: Table S12. Oligonucleotides, DNA primers, and antibodies used in this study. Oligonucleotides were used for sgRNA vector construction; DNA primers were used to analyze Cas9-mediated indels by Sanger sequencing; antibodies were used for Western blotting, immunoprecipitation, or ChIP-seq analysis.
DOI: 10.6084/m9.figshare.28517174
title: Additional file 1 of Blood metabolites reflect the effect of gut microbiota on differentiated thyroid cancer: a Mendelian randomization analysis

description: Supplementary Material 1.
DOI: 10.6084/m9.figshare.28517174.v1
title: Additional file 1 of Blood metabolites reflect the effect of gut microbiota on differentiated thyroid cancer: a Mendelian randomization analysis

description: Supplementary Material 1.
DOI: 10.6084/m9.figshare.28517177
title: Additional file 2 of Blood metabolites reflect the effect of gut microbiota on differentiated thyroid cancer: a Mendelian randomization analysis

description: Supplementary Material 2.
DOI: 10.6084/m9.figshare.28517180
title: Additional file 3 of Blood metabolites reflect the effect of gut microbiota on differentiated thyroid cancer: a Mendelian randomization analysis

description: Supplementary Material 3.
DOI: 10.6084/m9.figshare.28517180.v1
title: Additional file 3 of Blood metabolites reflect the effect of gut microbiota on differentiated thyroid cancer: a Mendelian randomization analysis

description: Supplementary Material 3.
DOI: 10.6084/m9.figshare.28472877
title: Investigation of bioavailability and anti-pancreatic cancer efficacy of a self-nanoemulsifying erlotinib delivery system

description: A new self-nanoemulsifying drug delivery system (SNEDDS) was developed for erlotinib (Ert) oral delivery. A pseudo-ternary phase diagram for olive oil, Tween 80 and polyethylene glycol (PEG) 600 mixtures, was firstly constructed. Based on the data about Ert solubility and cytotoxicity of these components, a SNEDDS composed of 10% olive oil, 20% Tween 80 and 70% (V/V) polyethylene glycol 600 was selected for Ert loading (Ert-SNEDDS). SNEDDS formed 31.2-nm droplets upon dilution in water, and Ert loading led to increment in the oil droplets to 83.9 ± 0.6 nm. Ert-SNEDDS represented a loading capacity and an entrapment efficiency of 22.7 ± 0.7 and 40.7 ± 0.5%, respectively. Ert release from Ert-SNEDDS was monitored in both a mixture of phosphate buffer saline and 0.5% Tween 80, and artificial gastric fluid. Ert-SNEDDS was orally administrated in rats, and the Ert plasma level was monitored over time to measure pharmacokinetic parameters. Ert-SNEDDS led to enhancement in the drug bioavailability and changed the release route of Ert. Ert-SNEDDS showed enhanced cytotoxicity toward ASPC-1 and PANC-1 cells, and half-maximal inhibitory concentration values were obtained and compared with free Ert. Ert-SNEDDS may be considered as an alternative route for oral Ert delivery.
DOI: 10.6084/m9.figshare.28472877.v1
title: Investigation of bioavailability and anti-pancreatic cancer efficacy of a self-nanoemulsifying erlotinib delivery system

description: A new self-nanoemulsifying drug delivery system (SNEDDS) was developed for erlotinib (Ert) oral delivery. A pseudo-ternary phase diagram for olive oil, Tween 80 and polyethylene glycol (PEG) 600 mixtures, was firstly constructed. Based on the data about Ert solubility and cytotoxicity of these components, a SNEDDS composed of 10% olive oil, 20% Tween 80 and 70% (V/V) polyethylene glycol 600 was selected for Ert loading (Ert-SNEDDS). SNEDDS formed 31.2-nm droplets upon dilution in water, and Ert loading led to increment in the oil droplets to 83.9 ± 0.6 nm. Ert-SNEDDS represented a loading capacity and an entrapment efficiency of 22.7 ± 0.7 and 40.7 ± 0.5%, respectively. Ert release from Ert-SNEDDS was monitored in both a mixture of phosphate buffer saline and 0.5% Tween 80, and artificial gastric fluid. Ert-SNEDDS was orally administrated in rats, and the Ert plasma level was monitored over time to measure pharmacokinetic parameters. Ert-SNEDDS led to enhancement in the drug bioavailability and changed the release route of Ert. Ert-SNEDDS showed enhanced cytotoxicity toward ASPC-1 and PANC-1 cells, and half-maximal inhibitory concentration values were obtained and compared with free Ert. Ert-SNEDDS may be considered as an alternative route for oral Ert delivery.
DOI: 10.6084/m9.figshare.28490228
title: Gastroretentive microballoons of olmesartan medoxomil: formulation and <i>in vitro-in vivo</i> evaluation

description: Olmesartan medoxomil, classified as BCS class II due to its poor water solubility, exhibits a low oral bioavailability of 28.6%. Microballoons of Olmesartan medoxomil were formulated using the ionotropic gelation technique and subjected to various evaluation parameters. The particles were found to be in the range of 85.11 to 312.6 µm. The prepared microballoons remained buSSoyant for more than 12 hours and showed percentage of cumulative drug release between 56.32–83.62%. <i>In vivo</i> studies showed significant reduction in Systolic blood pressure (SBP) in optimized formulation (OF). The formulated microballoons (hollow microspheres) emerged as a promising option for an oral gastro retentive controlled drug delivery system for Olmesartan medoxomil. Floating microballoons were formulated, optimized, and assessed to achieve improved bioavailability along with sustained release characteristics.
DOI: 10.6084/m9.figshare.28490228.v1
title: Gastroretentive microballoons of olmesartan medoxomil: formulation and <i>in vitro-in vivo</i> evaluation

description: Olmesartan medoxomil, classified as BCS class II due to its poor water solubility, exhibits a low oral bioavailability of 28.6%. Microballoons of Olmesartan medoxomil were formulated using the ionotropic gelation technique and subjected to various evaluation parameters. The particles were found to be in the range of 85.11 to 312.6 µm. The prepared microballoons remained buSSoyant for more than 12 hours and showed percentage of cumulative drug release between 56.32–83.62%. <i>In vivo</i> studies showed significant reduction in Systolic blood pressure (SBP) in optimized formulation (OF). The formulated microballoons (hollow microspheres) emerged as a promising option for an oral gastro retentive controlled drug delivery system for Olmesartan medoxomil. Floating microballoons were formulated, optimized, and assessed to achieve improved bioavailability along with sustained release characteristics.
DOI: 10.6084/m9.figshare.28323247
title: SN-38-indoximod conjugate: carrier free nano-prodrug for cancer therapy

description: The integration of immunotherapy alongside chemotherapy represents a crucial approach in the treatment of cancer. Herein we report the SN-38-indoximod conjugate nano-prodrug to address the difficulties encountered by individuals. In this prodrug, SN-38 is connected to indoximod through a specific disulfide linker, which enables the release of the components in response to the tumor microenvironment characterized by elevated levels of glutathione, thereby facilitating programmed chemoimmunotherapy. SN-38-indoximod conjugate was synthesized and fabricated to nano-prodrug by reprecipitation method. It showed comparable anti-cancer activity against A549 cells than SN-38 (IC<sub>50</sub> = 0.24 ± 0.01 µM) with IC<sub>50</sub> value 0.32 ± 0.04 µM. It inhibited 90% A549 cell at very lower concentration (IC<sub>90</sub> = 6.07 ± 0.41 µM) as compared with SN-38 (IC<sub>90</sub> = 24.60 ± 1.24 µM) and mixture of SN-38: indoximod (1:1, IC<sub>90</sub> &gt;30 µM). The nano-prodrug showed better size distribution profile and dispersion stability contains nanoparticles in effective size range (80–160 nm) required for the EPR effect. This research offers valuable insights into the advancement of conjugate nano-prodrugs exhibiting synergistic pharmacological effects, while also presenting novel opportunities for the design of prodrug molecules capable of releasing drugs in response to diverse triggers.
DOI: 10.6084/m9.figshare.28323247.v1
title: SN-38-indoximod conjugate: carrier free nano-prodrug for cancer therapy

description: The integration of immunotherapy alongside chemotherapy represents a crucial approach in the treatment of cancer. Herein we report the SN-38-indoximod conjugate nano-prodrug to address the difficulties encountered by individuals. In this prodrug, SN-38 is connected to indoximod through a specific disulfide linker, which enables the release of the components in response to the tumor microenvironment characterized by elevated levels of glutathione, thereby facilitating programmed chemoimmunotherapy. SN-38-indoximod conjugate was synthesized and fabricated to nano-prodrug by reprecipitation method. It showed comparable anti-cancer activity against A549 cells than SN-38 (IC<sub>50</sub> = 0.24 ± 0.01 µM) with IC<sub>50</sub> value 0.32 ± 0.04 µM. It inhibited 90% A549 cell at very lower concentration (IC<sub>90</sub> = 6.07 ± 0.41 µM) as compared with SN-38 (IC<sub>90</sub> = 24.60 ± 1.24 µM) and mixture of SN-38: indoximod (1:1, IC<sub>90</sub> &gt;30 µM). The nano-prodrug showed better size distribution profile and dispersion stability contains nanoparticles in effective size range (80–160 nm) required for the EPR effect. This research offers valuable insights into the advancement of conjugate nano-prodrugs exhibiting synergistic pharmacological effects, while also presenting novel opportunities for the design of prodrug molecules capable of releasing drugs in response to diverse triggers.
DOI: 10.6084/m9.figshare.28517176
title: Additional file 7 of Comparative transcriptome analysis reveals potential regulatory genes involved in the development and strength formation of maize stalks

description: Supplementary Material 7
DOI: 10.6084/m9.figshare.28517176.v1
title: Additional file 7 of Comparative transcriptome analysis reveals potential regulatory genes involved in the development and strength formation of maize stalks

description: Supplementary Material 7
DOI: 10.6084/m9.figshare.28517179
title: Additional file 8 of Comparative transcriptome analysis reveals potential regulatory genes involved in the development and strength formation of maize stalks

description: Supplementary Material 8
DOI: 10.6084/m9.figshare.28517179.v1
title: Additional file 8 of Comparative transcriptome analysis reveals potential regulatory genes involved in the development and strength formation of maize stalks

description: Supplementary Material 8
DOI: 10.6084/m9.figshare.28517182
title: Additional file 9 of Comparative transcriptome analysis reveals potential regulatory genes involved in the development and strength formation of maize stalks

description: Supplementary Material 9
DOI: 10.6084/m9.figshare.28517182.v1
title: Additional file 9 of Comparative transcriptome analysis reveals potential regulatory genes involved in the development and strength formation of maize stalks

description: Supplementary Material 9
DOI: 10.6084/m9.figshare.28517185
title: Additional file 10 of Comparative transcriptome analysis reveals potential regulatory genes involved in the development and strength formation of maize stalks

description: Supplementary Material 10
DOI: 10.6084/m9.figshare.28517185.v1
title: Additional file 10 of Comparative transcriptome analysis reveals potential regulatory genes involved in the development and strength formation of maize stalks

description: Supplementary Material 10
DOI: 10.6084/m9.figshare.28517188
title: Additional file 11 of Comparative transcriptome analysis reveals potential regulatory genes involved in the development and strength formation of maize stalks

description: Supplementary Material 11
DOI: 10.6084/m9.figshare.28517188.v1
title: Additional file 11 of Comparative transcriptome analysis reveals potential regulatory genes involved in the development and strength formation of maize stalks

description: Supplementary Material 11
DOI: 10.6084/m9.figshare.28517191
title: Additional file 12 of Comparative transcriptome analysis reveals potential regulatory genes involved in the development and strength formation of maize stalks

description: Supplementary Material 12
DOI: 10.6084/m9.figshare.28517191.v1
title: Additional file 12 of Comparative transcriptome analysis reveals potential regulatory genes involved in the development and strength formation of maize stalks

description: Supplementary Material 12
DOI: 10.6084/m9.figshare.28517194
title: Additional file 13 of Comparative transcriptome analysis reveals potential regulatory genes involved in the development and strength formation of maize stalks

description: Supplementary Material 13
DOI: 10.6084/m9.figshare.28517194.v1
title: Additional file 13 of Comparative transcriptome analysis reveals potential regulatory genes involved in the development and strength formation of maize stalks

description: Supplementary Material 13
DOI: 10.6084/m9.figshare.28517197
title: Additional file 14 of Comparative transcriptome analysis reveals potential regulatory genes involved in the development and strength formation of maize stalks

description: Supplementary Material 14
DOI: 10.6084/m9.figshare.28517197.v1
title: Additional file 14 of Comparative transcriptome analysis reveals potential regulatory genes involved in the development and strength formation of maize stalks

description: Supplementary Material 14
DOI: 10.6084/m9.figshare.28517200
title: Additional file 15 of Comparative transcriptome analysis reveals potential regulatory genes involved in the development and strength formation of maize stalks

description: Supplementary Material 15
DOI: 10.6084/m9.figshare.28517200.v1
title: Additional file 15 of Comparative transcriptome analysis reveals potential regulatory genes involved in the development and strength formation of maize stalks

description: Supplementary Material 15
DOI: 10.6084/m9.figshare.28517203
title: Additional file 16 of Comparative transcriptome analysis reveals potential regulatory genes involved in the development and strength formation of maize stalks

description: Supplementary Material 16
DOI: 10.58033/v0tf-xj82
title: Dolutegravir pharmacokinetics in pregnant and postpartum women living with HIV (dataset)
DOI: 10.17632/2hght7dmk5
title: Deubiquitinases in macrophages infected with Salmonella enterica or Yersinia enterocolitica

description: We used an activity-based proteomics screen of deubiquitinases in human macrophages to identify several deubiquitinases regulated in THP-1 derived macrophages during infection with Salmonella Typhimurium and Yersinia enterocolitica at 2 and 18 hours of infection.
DOI: 10.17632/4sk92gx628
title: Data from: Deciphering the biology and chemistry of the mutualistic partnership between Bacillus velezensis and the mycorrhizal fungus Rhizophagus irregularis

description: Arbuscular mycorrhizal (AM) fungi (e.g. Rhizophagus species) recruit specific bacterial species in their hyphosphere. However, the chemical interplay and the mutual benefit of this intricate partnership have not been investigated yet, especially as it involves bacteria known as strong producers of antifungal compounds such as Bacillus velezensis. Here, we show that the soil dwelling B. velezensis migrates along the hyphal network of the AM fungus R. irregularis, forming biofilms and inducing cytoplasmic flow in the AM fungus that contributes to host plant root colonization by the bacterium. During hyphosphere colonization, R. irregularis modulates the biosynthesis of specialized metabolites in B. velezensis to ensure stable coexistence and as a mechanism toward-off mycoparasitic fungi and bacteria. These mutual benefits are extended into a tripartite context via the provision of enhanced protection to the host plant through the induction of systemic resistance.
DOI: 10.5281/zenodo.14948645
title: Anonymous dataset for ICCV
DOI: 10.5281/zenodo.14948646
title: Anonymous dataset for ICCV
DOI: 10.5281/zenodo.14948709
title: Anonymous dataset for ICCV
DOI: 10.5281/zenodo.14948731
title: Anonymous dataset for ICCV
DOI: 10.15468/dl.3t9674
title: Occurrence Download

description: A dataset containing 13 species occurrences available in GBIF matching the query:
{
 "and" : [
 "OccurrenceStatus is Present",
 "TaxonKey is Lithocarpus perakensis Soepadmo"
 ]
}

 The dataset includes 13 records from 4 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0001678-250227182430271/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.vy9f5f
title: Occurrence Download

description: A dataset containing 669117 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Poa annua L.)",
 "BasisOfRecord is one of (Machine Observation, Human Observation, Observation, Literature Occurrence)",
 "HasCoordinate is true"
 ]
}

 The dataset includes 669117 records from 2765 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0001627-250227182400228/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.qzm5ak
title: Occurrence Download

description: A dataset containing 1298 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Lasioglossum anhypops McGinley, 1986"
 ]
}

 The dataset includes 1298 records from 15 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0011665-250402121839773/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.13145/bacdive6418.20241212.9.2
title: Ligilactobacillus araffinosus (Fujisawa et al. 1986) Zheng et al. 2020

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.13145/bacdive6418.20251217.10
title: Ligilactobacillus araffinosus (Fujisawa et al. 1986) Zheng et al. 2020

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.15156/bio/sh0074459.10fu
title: SH0074459.10FU

description: UNITE provides a unified way for delimiting, identifying, communicating, and working with DNA-based Species Hypotheses (SH). All fungal ITS sequences in the international nucleotide sequence databases are clustered to approximately the species level by applying a set of dynamic distance values (<0.5 - 3.0%). All species hypotheses are given a unique, stable name in the form of a DOI, and their taxonomic and ecological annotations are verified through distributed, web-based third-party annotation efforts. SHs are connected to a taxon name and its classification as far as possible (phylum, class, order, etc.) by taking into account identifications for all sequences in the SH. An automatically or manually designated sequence is chosen to represent each such SH. These sequences are released (https://unite.ut.ee/repository.php) for use by the scientific community in, for example, local sequence similarity searches and next-generation sequencing analysis pipelines. The system and the data are updated automatically as the number of public fungal ITS sequences grows.
DOI: 10.13145/bacdive6419.20241212.9.2
title: Ligilactobacillus aviarius (Fujisawa et al. 1985) Zheng et al. 2020

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.13145/bacdive6419.20251217.10
title: Ligilactobacillus aviarius (Fujisawa et al. 1985) Zheng et al. 2020

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.15156/bio/sh0074460.10fu
title: SH0074460.10FU

description: UNITE provides a unified way for delimiting, identifying, communicating, and working with DNA-based Species Hypotheses (SH). All fungal ITS sequences in the international nucleotide sequence databases are clustered to approximately the species level by applying a set of dynamic distance values (<0.5 - 3.0%). All species hypotheses are given a unique, stable name in the form of a DOI, and their taxonomic and ecological annotations are verified through distributed, web-based third-party annotation efforts. SHs are connected to a taxon name and its classification as far as possible (phylum, class, order, etc.) by taking into account identifications for all sequences in the SH. An automatically or manually designated sequence is chosen to represent each such SH. These sequences are released (https://unite.ut.ee/repository.php) for use by the scientific community in, for example, local sequence similarity searches and next-generation sequencing analysis pipelines. The system and the data are updated automatically as the number of public fungal ITS sequences grows.
DOI: 10.13145/bacdive6420.20250331.9.3
title: Ligilactobacillus aviarius (Fujisawa et al. 1985) Zheng et al. 2020

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.