cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.14601936
title: Additional file 1 of Comparative analysis of chloroplast genome structure and molecular dating in Myrtales

description: Additional file 1: Figures S1–S6. are phylogenetic relationships inferred by Maximum Likelihood and Bayesian inference based on: coding genes; noncoding loci; the LSC (the Large Single-Copy); the SSC (the Small Single-Copy); NO-IRa data set (data set composition is described in the methods) and IRb (Inverted Repeat region). Support values are maximum likelihood bootstrap support/Bayesian posterior probability. The families of Myrtales are indicated by different colors. For each figure, the inset shows the same tree as a phylogram (except for some inconsistencies in the phylogenetic relationships of IR dataset construction). The support value on the branch is bootstrap value/Bayesian posterior probability: “*” means 100% /1.0 support value, and “-” means bootstrap value/Bayesian posterior probability is less than 60 / 0.7. The families of Myrtales are represented by different colors. The small picture in the upper left corner is the ML phylogenetic tree (showing branch length).
DOI: 10.6084/m9.figshare.14601936.v1
title: Additional file 1 of Comparative analysis of chloroplast genome structure and molecular dating in Myrtales

description: Additional file 1: Figures S1–S6. are phylogenetic relationships inferred by Maximum Likelihood and Bayesian inference based on: coding genes; noncoding loci; the LSC (the Large Single-Copy); the SSC (the Small Single-Copy); NO-IRa data set (data set composition is described in the methods) and IRb (Inverted Repeat region). Support values are maximum likelihood bootstrap support/Bayesian posterior probability. The families of Myrtales are indicated by different colors. For each figure, the inset shows the same tree as a phylogram (except for some inconsistencies in the phylogenetic relationships of IR dataset construction). The support value on the branch is bootstrap value/Bayesian posterior probability: “*” means 100% /1.0 support value, and “-” means bootstrap value/Bayesian posterior probability is less than 60 / 0.7. The families of Myrtales are represented by different colors. The small picture in the upper left corner is the ML phylogenetic tree (showing branch length).
DOI: 10.6084/m9.figshare.14601947
title: Additional file 1 of Identifying collateral and synthetic lethal vulnerabilities within the DNA-damage response

description: Additional file 1. The list of the datasets involved in this study.
DOI: 10.6084/m9.figshare.14601947.v1
title: Additional file 1 of Identifying collateral and synthetic lethal vulnerabilities within the DNA-damage response

description: Additional file 1. The list of the datasets involved in this study.
DOI: 10.6084/m9.figshare.14601950
title: Additional file 2 of Identifying collateral and synthetic lethal vulnerabilities within the DNA-damage response

description: Additional file 2. The p value and the HDMI score for each pair of gene clusters.
DOI: 10.6084/m9.figshare.14601950.v1
title: Additional file 2 of Identifying collateral and synthetic lethal vulnerabilities within the DNA-damage response

description: Additional file 2. The p value and the HDMI score for each pair of gene clusters.
DOI: 10.6084/m9.figshare.14601953
title: Additional file 3 of Identifying collateral and synthetic lethal vulnerabilities within the DNA-damage response

description: Additional file 3. 660 gene clusters identified.
DOI: 10.6084/m9.figshare.14601953.v1
title: Additional file 3 of Identifying collateral and synthetic lethal vulnerabilities within the DNA-damage response

description: Additional file 3. 660 gene clusters identified.
DOI: 10.15468/sqdmt9
title: Three New Species Of Tyloperla Sivec & Stark (Plecoptera: Perlidae) From India

description: This dataset contains the digitized treatments in Plazi based on the original journal article Stark, Bill P., Sivec, Ignac (2014): Three New Species Of Tyloperla Sivec & Stark (Plecoptera: Perlidae) From India. Illiesia 10 (4): 32-42, DOI: http://doi.org/10.5281/zenodo.4757611
DOI: 10.15468/2q92vd
title: Morphology And Systematic Position Of Two Leuctra Species (Plecoptera: Leuctridae) Believed To Have No Specilla

description: This dataset contains the digitized treatments in Plazi based on the original journal article Zwick, Peter, Vinçon, Gilles, Figueroa, José Manuel Tierno de (2014): Morphology And Systematic Position Of Two Leuctra Species (Plecoptera: Leuctridae) Believed To Have No Specilla. Illiesia 10 (5): 43-51, DOI: http://doi.org/10.5281/zenodo.4757634
DOI: 10.6084/m9.figshare.14602014
title: Gene database of Severe acute respiratory syndrome (SARS) virus

description: This work presents the gene database of Severe acute respiratory syndrome (SARS) virus. Using annotated genome sequence downloaded from Genbank, an in-house MATLAB genome analysis software parsed the contents into a gene database comprising gene name, gene function, and gene sequence. Overall, the presented gene database of SARS is fundamental to initiating studies in understanding the origins and pathogenic potential of this virus.
DOI: 10.6084/m9.figshare.14602017
title: Gene database of Middle East respiratory syndrome (MERS) virus

description: This work presents the gene database of Middle East respiratory syndrome (MERS) virus. Using annotated genome sequence downloaded from Genbank, an in-house MATLAB genome analysis software parsed the contents into a gene database comprising gene name, gene function, and gene sequence. Overall, the presented gene database of MERS is fundamental to initiating studies in understanding the origins and pathogenic potential of this virus.
DOI: 10.34944/dspace/6366
title: Tamoxifen Breast Reconstruction Systematic Review Search Strategy

description: To identify studies to include or consider for this systematic review, the review team worked with a medical librarian to develop detailed search strategies for each database. The search was developed for PubMed (NLM) and was translated to Embase (Elsevier), Web of Science (Clarivate Analytics), CINAHL (EBSCOHost) and Cochrane Central (Wiley) using a combination of keywords and subject headings. A grey literature search included ClinicalTrials.gov and the TRIP database. The search included no major limits or date restrictions. The final search was completed on April 27, 2021. The full search details are provided in Appendix(___). PubMed (NLM) from inception to 4/27/21 (4,914 Results) Embase (Elsevier) from inception to 4/27/21 (3,499 Results) Web of Science (Clarivate Analytics) from inception to 4/27/21 (107 Results) CINAHL (EBSCOHost) from inception to 4/27/21 (1,675 Results) Cochrane Central (Wiley) from inception to 4/27/21 (7 Results) The search resulted in 10,280 studies (78 from grey literature sources). 986 duplicate studies were found and omitted using Endnote X.7 for the deduplication of records and 9,294 references were eligible to screen. Studies were screened by title and abstract by two blinded and independent reviewers. If a tiebreaker was needed, a third reviewer was called in. This process was repeated for full text article screening and article selection.
description: To identify studies to include or consider for this systematic review, the review team worked with a medical librarian to develop detailed search strategies for each database. The search was developed for PubMed (NLM) and was translated to Embase (Elsevier), Web of Science (Clarivate Analytics), CINAHL (EBSCOHost) and Cochrane Central (Wiley) using a combination of keywords and subject headings. A grey literature search included ClinicalTrials.gov and the TRIP database. The search included no major limits or date restrictions. The final search was completed on April 27, 2021.
DOI: 10.15468/3fb9ef
title: New And Interesting Records Of Plecoptera (Insecta) From Slovakia And Several Autecology Notes

description: This dataset contains the digitized treatments in Plazi based on the original journal article Žiak, Matej, Krno, Il'ja (2014): New And Interesting Records Of Plecoptera (Insecta) From Slovakia And Several Autecology Notes. Illiesia 10 (6): 52-59, DOI: http://doi.org/10.5281/zenodo.4757651
DOI: 10.6084/m9.figshare.14600409
title: Achi_genome_v1

description: This is the fasta file of Achi genome assembly
DOI: 10.6084/m9.figshare.14600409.v2
title: Achi_genome_v1

description: This is the fasta file of Achi genome assembly
DOI: 10.6084/m9.figshare.14600409.v1
title: A. chinensis's chromosomal genome assembly fasta file

description: This is the fasta file of Achi genome assembly
DOI: 10.6084/m9.figshare.14602020
title: Gene database of Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)

description: This work presents the gene database of Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Using annotated genome sequence downloaded from Genbank, an in-house MATLAB genome analysis software parsed the contents into a gene database comprising gene name, gene function, and gene sequence. Overall, the presented gene database of SARS-CoV-2 is fundamental to initiating studies in understanding the origins and pathogenic potential of this virus.
DOI: 10.15468/2x3g6z
title: Type Designation For Neoperla Furcomaculata Kong & Li, 2014 (Plecoptera: Perlidae)

description: This dataset contains the digitized treatments in Plazi based on the original journal article Kong, Fanbin, Li, Weihai (2016): Type Designation For Neoperla Furcomaculata Kong & Li, 2014 (Plecoptera: Perlidae). Illiesia 12 (10): 59, DOI: http://doi.org/10.5281/zenodo.4765418
DOI: 10.15468/7cg26y
title: Distribution Of Hydroperla Fugitans (Plecoptera: Perlodidae) With Notes On Diet

description: This dataset contains the digitized treatments in Plazi based on the original journal article Harrison, Audrey B., DeWalt, R. Edward (2017): Distribution Of Hydroperla Fugitans (Plecoptera: Perlodidae) With Notes On Diet. Illiesia 13 (11): 104-110, DOI: http://doi.org/10.5281/zenodo.4757773
DOI: 10.25934/00003069.0
title: Data Package for study.

description: Vivli is an independent, non-profit organization that has developed a global data-sharing and analytics platform to serve all elements of the international research community. Our mission is to promote, coordinate, and facilitate scientific sharing and reuse of clinical research data through the creation and implementation of a sustainable global data-sharing enterprise. The Vivli platform includes an independent data repository, in-depth search engine and a cloud-based, secure analytics platform.
DOI: 10.25934/00003069.1
title: IPD datapackage for study 'A Double-Blind, Randomized, Parallel-Arm, Multicenter Study to Determine the Dose Response of Methotrexate (MTX) in Combination Therapy With Adalimumab in Subjects With Early Rheumatoid Arthritis (CONCERTO)' and research request: 'Predicting the Treatment Response of Biologics for Individual Patients with Rheumatoid Arthritis: An Individual Participant Data Meta-Analysis '

description: Vivli is an independent, non-profit organization that has developed a global data-sharing and analytics platform to serve all elements of the international research community. Our mission is to promote, coordinate, and facilitate scientific sharing and reuse of clinical research data through the creation and implementation of a sustainable global data-sharing enterprise. The Vivli platform includes an independent data repository, in-depth search engine and a cloud-based, secure analytics platform.
DOI: 10.15468/hf4sgj
title: A New Species Of Isoperla Banks (Plecoptera: Perlodidae) From The Southern Appalachians, With Notes On The I. Montana Group

description: This dataset contains the digitized treatments in Plazi based on the original journal article Verdone, Chris J., Kondratieff, Boris C. (2017): A New Species Of Isoperla Banks (Plecoptera: Perlodidae) From The Southern Appalachians, With Notes On The I. Montana Group. Illiesia 13 (12): 111-126, DOI: http://doi.org/10.5281/zenodo.4757785
DOI: 10.25934/00003024.0
title: Available IPD datapackage for study 'A Non-Randomized, Open-Label, Roll-Over Study With Self Injection of Adalimumab in Adult Japanese Subjects With Rheumatoid Arthritis'

description: Vivli is an independent, non-profit organization that has developed a global data-sharing and analytics platform to serve all elements of the international research community. Our mission is to promote, coordinate, and facilitate scientific sharing and reuse of clinical research data through the creation and implementation of a sustainable global data-sharing enterprise. The Vivli platform includes an independent data repository, in-depth search engine and a cloud-based, secure analytics platform.
DOI: 10.25934/00003024.1
title: IPD datapackage for study 'A Non-Randomized, Open-Label, Roll-Over Study With Self Injection of Adalimumab in Adult Japanese Subjects With Rheumatoid Arthritis' and research request: 'Predicting the Treatment Response of Biologics for Individual Patients with Rheumatoid Arthritis: An Individual Participant Data Meta-Analysis '

description: Vivli is an independent, non-profit organization that has developed a global data-sharing and analytics platform to serve all elements of the international research community. Our mission is to promote, coordinate, and facilitate scientific sharing and reuse of clinical research data through the creation and implementation of a sustainable global data-sharing enterprise. The Vivli platform includes an independent data repository, in-depth search engine and a cloud-based, secure analytics platform.
DOI: 10.25934/00003084.0
title: Available IPD datapackage for study 'A Multicenter, Randomized, Single-Blind Crossover Study of the Safety and Tolerability of Two Adalimumab Formulations in Adult Subjects With Rheumatoid Arthritis'

description: Vivli is an independent, non-profit organization that has developed a global data-sharing and analytics platform to serve all elements of the international research community. Our mission is to promote, coordinate, and facilitate scientific sharing and reuse of clinical research data through the creation and implementation of a sustainable global data-sharing enterprise. The Vivli platform includes an independent data repository, in-depth search engine and a cloud-based, secure analytics platform.
DOI: 10.25934/00003084.1
title: IPD datapackage for study 'A Multicenter, Randomized, Single-Blind Crossover Study of the Safety and Tolerability of Two Adalimumab Formulations in Adult Subjects With Rheumatoid Arthritis' and research request: 'Predicting the Treatment Response of Biologics for Individual Patients with Rheumatoid Arthritis: An Individual Participant Data Meta-Analysis '

description: Vivli is an independent, non-profit organization that has developed a global data-sharing and analytics platform to serve all elements of the international research community. Our mission is to promote, coordinate, and facilitate scientific sharing and reuse of clinical research data through the creation and implementation of a sustainable global data-sharing enterprise. The Vivli platform includes an independent data repository, in-depth search engine and a cloud-based, secure analytics platform.
DOI: 10.25934/00003068.0
title: Available IPD datapackage for study 'A Multicenter, Double-Blind, Randomized, Parallel-Arm Study to Determine the Effect of Methotrexate Dose on Clinical Outcome and Ultrasonographic Signs in Subjects With Moderately to Severely Active Rheumatoid Arthritis Treated With Adalimumab (MUSICA)'

description: Vivli is an independent, non-profit organization that has developed a global data-sharing and analytics platform to serve all elements of the international research community. Our mission is to promote, coordinate, and facilitate scientific sharing and reuse of clinical research data through the creation and implementation of a sustainable global data-sharing enterprise. The Vivli platform includes an independent data repository, in-depth search engine and a cloud-based, secure analytics platform.
DOI: 10.25934/00003068.1
title: IPD datapackage for study 'A Multicenter, Double-Blind, Randomized, Parallel-Arm Study to Determine the Effect of Methotrexate Dose on Clinical Outcome and Ultrasonographic Signs in Subjects With Moderately to Severely Active Rheumatoid Arthritis Treated With Adalimumab (MUSICA)' and research request: 'Predicting the Treatment Response of Biologics for Individual Patients with Rheumatoid Arthritis: An Individual Participant Data Meta-Analysis '

description: Vivli is an independent, non-profit organization that has developed a global data-sharing and analytics platform to serve all elements of the international research community. Our mission is to promote, coordinate, and facilitate scientific sharing and reuse of clinical research data through the creation and implementation of a sustainable global data-sharing enterprise. The Vivli platform includes an independent data repository, in-depth search engine and a cloud-based, secure analytics platform.
DOI: 10.15468/fe297d
title: A New Species Of Diploperla Needham And Claassen (Plecoptera: Perlodidae) From North Carolina And Virginia

description: This dataset contains the digitized treatments in Plazi based on the original journal article Kondratieff, Boris C., Verdone, Chris J. (2017): A New Species Of Diploperla Needham And Claassen (Plecoptera: Perlodidae) From North Carolina And Virginia. Illiesia 13 (13): 127-139, DOI: http://doi.org/10.5281/zenodo.4757827
DOI: 10.15468/sap25c
title: Holomorphology And Systematics Of The Eastern Nearctic Stonefly Genus Remenus Ricker (Plecoptera: Perlodidae)

description: This dataset contains the digitized treatments in Plazi based on the original journal article Verdone, Chris J., Kondratieff, Boris C. (2018): Holomorphology And Systematics Of The Eastern Nearctic Stonefly Genus Remenus Ricker (Plecoptera: Perlodidae). Illiesia 14 (5): 81-125, DOI: http://doi.org/10.5281/zenodo.4757871
DOI: 10.5517/ccdc.csd.cc24vnd2
title: CCDC 1991824: Experimental Crystal Structure Determination

description: Related Article: Hyunchul Kwon, Ewa Pietrasiak, Takashi Ohhara, Akiko Nakao, Boknam Chae, Chan-Cuk Hwang, Daesung Jung, In-Chul Hwang, Young Ho Ko, Kimoon Kim, Eunsung Lee|2021|Inorg.Chem.|60|6403|doi:10.1021/acs.inorgchem.1c00106
DOI: 10.5517/ccdc.csd.cc24vng4
title: CCDC 1991826: Experimental Crystal Structure Determination

description: Related Article: Hyunchul Kwon, Ewa Pietrasiak, Takashi Ohhara, Akiko Nakao, Boknam Chae, Chan-Cuk Hwang, Daesung Jung, In-Chul Hwang, Young Ho Ko, Kimoon Kim, Eunsung Lee|2021|Inorg.Chem.|60|6403|doi:10.1021/acs.inorgchem.1c00106
DOI: 10.5517/ccdc.csd.cc24vnh5
title: CCDC 1991827: Experimental Crystal Structure Determination

description: Related Article: Hyunchul Kwon, Ewa Pietrasiak, Takashi Ohhara, Akiko Nakao, Boknam Chae, Chan-Cuk Hwang, Daesung Jung, In-Chul Hwang, Young Ho Ko, Kimoon Kim, Eunsung Lee|2021|Inorg.Chem.|60|6403|doi:10.1021/acs.inorgchem.1c00106
DOI: 10.5517/ccdc.csd.cc24vnj6
title: CCDC 1991828: Experimental Crystal Structure Determination

description: Related Article: Hyunchul Kwon, Ewa Pietrasiak, Takashi Ohhara, Akiko Nakao, Boknam Chae, Chan-Cuk Hwang, Daesung Jung, In-Chul Hwang, Young Ho Ko, Kimoon Kim, Eunsung Lee|2021|Inorg.Chem.|60|6403|doi:10.1021/acs.inorgchem.1c00106
DOI: 10.5517/ccdc.csd.cc24vnk7
title: CCDC 1991829: Experimental Crystal Structure Determination

description: Related Article: Hyunchul Kwon, Ewa Pietrasiak, Takashi Ohhara, Akiko Nakao, Boknam Chae, Chan-Cuk Hwang, Daesung Jung, In-Chul Hwang, Young Ho Ko, Kimoon Kim, Eunsung Lee|2021|Inorg.Chem.|60|6403|doi:10.1021/acs.inorgchem.1c00106
DOI: 10.5517/ccdc.csd.cc24vnl8
title: CCDC 1991830: Experimental Crystal Structure Determination

description: Related Article: Hyunchul Kwon, Ewa Pietrasiak, Takashi Ohhara, Akiko Nakao, Boknam Chae, Chan-Cuk Hwang, Daesung Jung, In-Chul Hwang, Young Ho Ko, Kimoon Kim, Eunsung Lee|2021|Inorg.Chem.|60|6403|doi:10.1021/acs.inorgchem.1c00106
DOI: 10.5517/ccdc.csd.cc24vnqd
title: CCDC 1991834: Experimental Crystal Structure Determination

description: Related Article: Hyunchul Kwon, Ewa Pietrasiak, Takashi Ohhara, Akiko Nakao, Boknam Chae, Chan-Cuk Hwang, Daesung Jung, In-Chul Hwang, Young Ho Ko, Kimoon Kim, Eunsung Lee|2021|Inorg.Chem.|60|6403|doi:10.1021/acs.inorgchem.1c00106
DOI: 10.5517/ccdc.csd.cc260mrm
title: CCDC 2026400: Experimental Crystal Structure Determination

description: Related Article: Yair Cohen, André U. Augustin, Laura Levy, Peter G. Jones, Daniel B. Werz, Ilan Marek|2021|Angew.Chem.,Int.Ed.|60|11804|doi:10.1002/anie.202102509
DOI: 10.5517/ccdc.csd.cc26bmnv
title: CCDC 2036007: Experimental Crystal Structure Determination

description: Related Article: Hongfang Li, Ijaz Khan, Meiqi Li, Zheng Wang, Xue Wu, Kuiling Ding, Yong Jian Zhang|2021|Org.Lett.|23|3567|doi:10.1021/acs.orglett.1c00959
description: Related Article: Ijaz khan|2020|CSD Communication|||
DOI: 10.5517/ccdc.csd.cc26bmpw
title: CCDC 2036008: Experimental Crystal Structure Determination

description: Related Article: Hongfang Li, Ijaz Khan, Meiqi Li, Zheng Wang, Xue Wu, Kuiling Ding, Yong Jian Zhang|2021|Org.Lett.|23|3567|doi:10.1021/acs.orglett.1c00959
DOI: 10.5517/ccdc.csd.cc26jh8j
title: CCDC 2041637: Experimental Crystal Structure Determination

description: Related Article: Luis Nóvoa, Laura Trulli, Alejandro Parra, Mariola Tortosa|2021|Angew.Chem.,Int.Ed.|60|11763|doi:10.1002/anie.202101445
DOI: 10.5517/ccdc.csd.cc26jhbl
title: CCDC 2041639: Experimental Crystal Structure Determination

description: Related Article: Luis Nóvoa, Laura Trulli, Alejandro Parra, Mariola Tortosa|2021|Angew.Chem.,Int.Ed.|60|11763|doi:10.1002/anie.202101445
DOI: 10.5517/ccdc.csd.cc26jhgq
title: CCDC 2041643: Experimental Crystal Structure Determination

description: Related Article: Luis Nóvoa, Laura Trulli, Alejandro Parra, Mariola Tortosa|2021|Angew.Chem.,Int.Ed.|60|11763|doi:10.1002/anie.202101445
DOI: 10.25505/fiz.icsd.cc26pgds
title: CSD 2046415: Experimental Crystal Structure Determination

description: Related Article: Shannon J. Lee, Juyeon Won, Lin-Lin Wang, Dapeng Jing, Colin P. Harmer, Justin Mark, Georgiy Akopov, Kirill Kovnir|2021|Chem.-Eur.J.|27|7383|doi:10.1002/chem.202005312
DOI: 10.25505/fiz.icsd.cc26pgft
title: CSD 2046416: Experimental Crystal Structure Determination

description: Related Article: Shannon J. Lee, Juyeon Won, Lin-Lin Wang, Dapeng Jing, Colin P. Harmer, Justin Mark, Georgiy Akopov, Kirill Kovnir|2021|Chem.-Eur.J.|27|7383|doi:10.1002/chem.202005312
DOI: 10.25505/fiz.icsd.cc26pggv
title: CSD 2046417: Experimental Crystal Structure Determination

description: Related Article: Shannon J. Lee, Juyeon Won, Lin-Lin Wang, Dapeng Jing, Colin P. Harmer, Justin Mark, Georgiy Akopov, Kirill Kovnir|2021|Chem.-Eur.J.|27|7383|doi:10.1002/chem.202005312
DOI: 10.5517/ccdc.csd.cc26v48h
title: CCDC 2050906: Experimental Crystal Structure Determination

description: Related Article: Yair Cohen, André U. Augustin, Laura Levy, Peter G. Jones, Daniel B. Werz, Ilan Marek|2021|Angew.Chem.,Int.Ed.|60|11804|doi:10.1002/anie.202102509
DOI: 10.5517/ccdc.csd.cc26yg4s
title: CCDC 2054095: Experimental Crystal Structure Determination

description: Related Article: Marc Schnierle, Marie Leimkühler, Mark R. Ringenberg|2021|Inorg.Chem.|60|6367|doi:10.1021/acs.inorgchem.1c00094
DOI: 10.5517/ccdc.csd.cc26yg5t
title: CCDC 2054096: Experimental Crystal Structure Determination

description: Related Article: Marc Schnierle, Marie Leimkühler, Mark R. Ringenberg|2021|Inorg.Chem.|60|6367|doi:10.1021/acs.inorgchem.1c00094
DOI: 10.5517/ccdc.csd.cc26yp73
title: CCDC 2054315: Experimental Crystal Structure Determination

description: Related Article: Monika Kijewska, Miosz Siczek, Miosz Pawlicki|2021|Org.Lett.|23|3652|doi:10.1021/acs.orglett.1c01047
DOI: 10.5517/ccdc.csd.cc26yp84
title: CCDC 2054316: Experimental Crystal Structure Determination

description: Related Article: Monika Kijewska, Miosz Siczek, Miosz Pawlicki|2021|Org.Lett.|23|3652|doi:10.1021/acs.orglett.1c01047