DOI: 10.5061/dryad.7v72n64
title: Data from: Light pollution increases West Nile virus competence of a ubiquitous passerine reservoir species

description: Among the many anthropogenic changes that impact humans and wildlife, one
 of the most pervasive but least understood is light pollution. Although
 detrimental physiological and behavioral effects resulting from exposure
 to light at night are widely appreciated, the impacts of light pollution
 on infectious disease risk have not been studied. Here, we demonstrate
 that artificial light at night (ALAN) extends the infectious-to-vector
 period of the house sparrow (Passer domesticus), an urban-dwelling avian
 reservoir host of West Nile virus (WNV). Sparrows exposed to ALAN
 maintained transmissible viral titers for two days longer than controls
 but did not experience greater WNV-induced mortality during this window.
 Transcriptionally, ALAN altered the expression of gene regulatory networks
 including key hubs (OASL, PLBD1, TRAP1) and effector genes known to affect
 WNV dissemination (SOCS). Despite mounting anti-viral immune responses
 earlier, transcriptomic signatures indicated that ALAN-exposed individuals
 likely experienced pathogen induced damage and immunopathology,
 potentially due to evasion of immune effectors. A simple mathematical
 modelling exercise indicated that ALAN-induced increases of host
 infectious-to-vector period could increase WNV outbreak potential by ~41%.
 ALAN likely affects other host and vector traits relevant to transmission,
 and additional research is needed to advise management of zoonotic
 diseases in light polluted areas.
description: Kernbach_ALANViremiaCORTMortalityRawData2019CSV document that contains the raw data for viremia, CORT, body mass, and survival parameters.ALAN data proc b CSV.csvKernbach_GeneOntology_ALAN2dpevs6dpeGene ontology data for transcriptomic data for ALAN exposed days compared between days 2 and 6 post-exposureKernbach et al. Table S9.csvKernbach_GeneOntology_6dpeALANvsCtrlGene ontology for transcriptomic data comparing ALAN exposed and control birds on day 6Kernbach et al. Table S9_2.csvKernbach_GeneOntology_Ctrl2dpevs6dpeGene ontology transcriptomic results for control birds on day 2 post-exposure and day 6 post-exposureKernbach et al. Table S9_3.csvKernbach_GeneOntology_2dpeALANvsCtrlGene ontrology for transcriptomic results comparing ALAN exposed and control birds on day 2 post-exposureKernbach et al. Table S9_4.csvKernbach_DiffExp2dpeALANvsCtrlDifferential expression of genes comparing ALAN exposed and control birds on day 2 post-exposureKernbach et al. Table S10.csvKernbach_DiffExp6dpeALANvsCtrlDifferential expression on genes compared between ALAN exposed and control birds on day 6 post-exposureKernbach et al. Table S10_2.csvKernbach_DiffExpCtrl2dpes6dpeDifferential expression of genes in control birds between days 2 ad 6 post-exposureKernbach et al. Table S10_3.csvKernbach_DiffExpALAN2dpevs6dpeDifferential expression of genes in ALAN exposed birds between days 2 ad 6 post-exposureKernbach et al. Table S10_4.csvKernbach_WGCNAoverviewOverview of WGCNA results for transcriptomic dataKernbach et al. Table S11_overview.csvKernbach_WGCNA_modulemembershipModule membership of differentially expressed genes from the transcriptomic dataKernbach et al. Table S11_module_membership.csvKernbach_WGCNA_blueGenes belonging to the blue module.Kernbach et al. Table S11_blue.csvKernbach_WGCNA_purpleGenes belonging to the purple module.Kernbach et al. Table S11_purple.csvKernbach_WGCNA_tanGenes belonging to the tan module.Kernbach et al. Table S11_tan.csvKernbach_WGCNA_turquoiseGenes belonging to the turquoise module.Kernbach et al. Table S11_turq.csvKernbach_WGCNA_yellowGenes belonging to the yellow module.Kernbach et al. Table S11_yellow.csvReadME FileREADME file describing labels from all datasets.