cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.8235692
title: Does childhood experience of attention-deficit hyperactivity disorder symptoms increase sleep/wake cycle disturbances as measured with actigraphy in adult patients with bipolar disorder?

description: Childhood attention-deficit hyperactivity disorder (ADHD) is a common precursor of adult bipolar disorders (BD). Furthermore, actigraphy studies demonstrate that each disorder may be associated with abnormalities in sleep and activity patterns. This study investigates whether the presence or absence of self-reported childhood experiences of ADHD symptoms is associated with different sleep and activity patterns in adults with BD. A sample of 115 euthymic adult patients with BD was assessed for childhood ADHD symptoms using the Wender Utah Rating Scale (WURS) and then completed 21 days of actigraphy monitoring. Actigraphic measures of sleep quantity and variability and daytime activity were compared between BD groups classified as ADHD+ (<i>n</i> = 24) or ADHD− (<i>n</i> = 91), defined according to established cutoff scores for the WURS; then we examined any associations between sleep–wake cycle parameters and ADHD dimensions (using the continuous score on the WURS). Neither approach revealed any statistically significant associations between actigraphy parameters and childhood ADHD categories or dimensions. We conclude that the sleep and activity patterns of adult patients with BD do not differ according to their self-reported history of ADHD symptoms. We discuss the implications of these findings and suggest how future studies might confirm or refute our findings.
DOI: 10.6084/m9.figshare.8235683
title: FINAL_Search results methodology__ CL VAN GRAAN DISSERTATION.xlsx

description: Summary of the search results of the critical literature review of commercial forensic interviewing techniques relevant to South Africa
DOI: 10.6084/m9.figshare.8235689
title: <i>In vivo</i> lifetimes of the three color-sectors in bioluminescence emissions of the firefly <i>Luciola praeusta</i> at different temperatures

description: Bioluminescence emissions from fireflies have been well-studied for over a century. From the apparent features of the emitted light, conclusions have been drawn and hypotheses put forward on the characteristics of the highly efficient light emitting system. The basic emitter oxyluciferin, being chemically unstable, is difficult to study in isolation and, therefore, its analogs have been prepared and analyzed. In this letter, the lifetimes of the excited-state emitter oxyluciferin are measured, and an inference is drawn on the chemiluminescence reaction <i>in vivo</i>. The light from the Indian species of firefly <i>Luciola praeusta</i> contains three color-sectors: green, yellow, and red, and hence three optical filters are used to study time-resolved emissions from these sectors at different temperatures. All the three color-sectors are observed to be temperature sensitive in the time domain. An exponential variation of lifetime with temperature is observed for the emissions in these three regions.
DOI: 10.6084/m9.figshare.8235692.v1
title: Does childhood experience of attention-deficit hyperactivity disorder symptoms increase sleep/wake cycle disturbances as measured with actigraphy in adult patients with bipolar disorder?

description: Childhood attention-deficit hyperactivity disorder (ADHD) is a common precursor of adult bipolar disorders (BD). Furthermore, actigraphy studies demonstrate that each disorder may be associated with abnormalities in sleep and activity patterns. This study investigates whether the presence or absence of self-reported childhood experiences of ADHD symptoms is associated with different sleep and activity patterns in adults with BD. A sample of 115 euthymic adult patients with BD was assessed for childhood ADHD symptoms using the Wender Utah Rating Scale (WURS) and then completed 21 days of actigraphy monitoring. Actigraphic measures of sleep quantity and variability and daytime activity were compared between BD groups classified as ADHD+ (<i>n</i> = 24) or ADHD− (<i>n</i> = 91), defined according to established cutoff scores for the WURS; then we examined any associations between sleep–wake cycle parameters and ADHD dimensions (using the continuous score on the WURS). Neither approach revealed any statistically significant associations between actigraphy parameters and childhood ADHD categories or dimensions. We conclude that the sleep and activity patterns of adult patients with BD do not differ according to their self-reported history of ADHD symptoms. We discuss the implications of these findings and suggest how future studies might confirm or refute our findings.
DOI: 10.6084/m9.figshare.8235689.v1
title: <i>In vivo</i> lifetimes of the three color-sectors in bioluminescence emissions of the firefly <i>Luciola praeusta</i> at different temperatures

description: Bioluminescence emissions from fireflies have been well-studied for over a century. From the apparent features of the emitted light, conclusions have been drawn and hypotheses put forward on the characteristics of the highly efficient light emitting system. The basic emitter oxyluciferin, being chemically unstable, is difficult to study in isolation and, therefore, its analogs have been prepared and analyzed. In this letter, the lifetimes of the excited-state emitter oxyluciferin are measured, and an inference is drawn on the chemiluminescence reaction <i>in vivo</i>. The light from the Indian species of firefly <i>Luciola praeusta</i> contains three color-sectors: green, yellow, and red, and hence three optical filters are used to study time-resolved emissions from these sectors at different temperatures. All the three color-sectors are observed to be temperature sensitive in the time domain. An exponential variation of lifetime with temperature is observed for the emissions in these three regions.
DOI: 10.6084/m9.figshare.8235671
title: Supplementary Material for: Effects of Bardoxolone Methyl on Magnesium in Patients with Type 2 Diabetes Mellitus and Chronic Kidney Disease

description: <b><i>Background:</i></b> Treatment with bardoxolone methyl (Bard) in a multinational phase 3 trial, Bardoxolone Methyl Evaluation in Patients with Chronic Kidney Disease and Type 2 Diabetes (BEACON), resulted in increases in estimated glomerular filtration rate with concurrent reductions in serum magnesium. We analyzed data from several trials to characterize reductions in magnesium with Bard. <b><i>Methods:</i></b> BEACON randomized patients (<i>n</i> = 2,185) with type 2 diabetes (T2DM) and stage 4 chronic kidney disease (CKD) 1:1 to receive Bard (20 mg) or placebo once daily. In a separate open-label study, magnesium levels from 24-hour urine and sublingual epithelial cell samples were analyzed in patients with stage 3b-4 CKD and T2DM administered 20 mg Bard for 56 consecutive days. <b><i>Results:</i></b> BEACON patients randomized to Bard experienced significant reductions in serum magnesium from baseline relative to patients randomized to placebo (–0.17 mEq/L, 95% CI –0.18 to –0.60 mEq/L; <i>p</i> &lt; 0.001). A separate study showed intracellular and urinary magnesium levels were unchanged with Bard treatment. <b><i>Conclusions:</i></b> Bard treatment results in significant decreases in serum magnesium that are not associated with changes in intracellular and urinary magnesium levels, indicating that magnesium decreases are not due to renal magnesium wasting or total body magnesium depletion. Importantly, the decreases in serum magnesium with Bard are not associated with adverse effects on QT interval.
DOI: 10.6084/m9.figshare.8235683.v1
title: FINAL_Search results methodology__ CL VAN GRAAN DISSERTATION.xlsx

description: Summary of the search results of the critical literature review of commercial forensic interviewing techniques relevant to South Africa
DOI: 10.6084/m9.figshare.8235614
title: Synthetic Hunchback P2 Sequences for “Dissecting the sharp response of a canonical developmental enhancer reveals multiple sources of cooperativity”

description: This file contains sequences of synthetic versions of the Hunchback P2 enhancer, computationally designed to contain only Bicoid binding sites and various amounts of flanking sequence. These synthetic enhancers drive expression in the anterior of the Drosophila blastoderm embryo.<br>To create SynHbP2, SiteOut was used to remove motifs of interest (Estrada et al., 2016a). First the sequence of WThbP2 was scrambled to remove known motifs of TFs (Bcd, Cad, dStat, D, Gt, Hb, Kni, Kr, Nub, Tll, Zld) involved in AP patterning of the blastoderm embryo. Then Bcd TFBS were restored to their native locations and the resultant sequence checked for any newly created motifs around the restored Bcd TFBS using PATSER (http://stormo.wustl.edu/software.html). The binding motifs are from FlyFactorSurvey (http://pgfe.umassmed.edu/ffs/; Noyes et al., 2008b), and a pseudocount of 0.1 and a GC (guanine and cytosine) content of 0.406 when generating position weight matrices from these count matrices was used.
DOI: 10.6084/m9.figshare.8235554
title: Supplementary Material for: Shared Decision-Making for Patients with Advanced Urological Malignancies: Evaluation of a Joint Urological-Oncological Clinic Model

description: <b><i>Background:</i></b> To provide rapid evaluation of patients with advanced urological malignancies, a joint urological-oncological clinic was initiated at our institution in January 2015. We present the first 3-year evaluation of this joint urological-oncological clinic in Switzerland. <b><i>Method:</i></b> We performed a retrospective analysis of the characteristics and treatment of all patients reviewed at the joint clinic between January 2015 and December 2017. Statistical analysis was performed by survival analysis. A patient satisfaction questionnaire was handed out to new patients (from April to September 2017). <b><i>Results:</i></b> A total of 135 new patients were counseled in the joint clinic and 563 consultations were performed in the period from January 2015 to December 2017. The majority were men with prostate cancer (85%), followed by bladder cancer (9%), and renal cell carcinoma (4%). Men with newly diagnosed metastatic prostate cancer (<i>n</i> = 69) received ADT alone (57%), ADT with docetaxel or abiraterone (33%), and metastasis-directed therapy (10%). High rates of patient satisfaction were reported based on the questionnaire. <b><i>Conclusions:</i></b> The joint clinic model has been successfully implemented at our institution and continues on a weekly basis. The clinic is increasingly used, not only for newly diagnosed metastatic prostate cancer, but also for other complex uro-oncological cases. The clinic allows optimized oncological treatment without delay and with a reduced effort for patients.
DOI: 10.6084/m9.figshare.8235587
title: Position Weight Matrices used for HbP2 sequence analysis in “Dissecting the sharp response of a canonical developmental enhancer reveals multiple sources of cooperativity”

description: This file contains the position weight matrices used to analyze the sequence of the Hunchback P2 enhancer for transcription factor binding sites.<br>For SynHbP2, we used Position Weight Matrices to predict binding sites for other TFs to screen against the creation of those sites in our neutral backbone<br>
DOI: 10.6084/m9.figshare.8235554.v1
title: Supplementary Material for: Shared Decision-Making for Patients with Advanced Urological Malignancies: Evaluation of a Joint Urological-Oncological Clinic Model

description: <b><i>Background:</i></b> To provide rapid evaluation of patients with advanced urological malignancies, a joint urological-oncological clinic was initiated at our institution in January 2015. We present the first 3-year evaluation of this joint urological-oncological clinic in Switzerland. <b><i>Method:</i></b> We performed a retrospective analysis of the characteristics and treatment of all patients reviewed at the joint clinic between January 2015 and December 2017. Statistical analysis was performed by survival analysis. A patient satisfaction questionnaire was handed out to new patients (from April to September 2017). <b><i>Results:</i></b> A total of 135 new patients were counseled in the joint clinic and 563 consultations were performed in the period from January 2015 to December 2017. The majority were men with prostate cancer (85%), followed by bladder cancer (9%), and renal cell carcinoma (4%). Men with newly diagnosed metastatic prostate cancer (<i>n</i> = 69) received ADT alone (57%), ADT with docetaxel or abiraterone (33%), and metastasis-directed therapy (10%). High rates of patient satisfaction were reported based on the questionnaire. <b><i>Conclusions:</i></b> The joint clinic model has been successfully implemented at our institution and continues on a weekly basis. The clinic is increasingly used, not only for newly diagnosed metastatic prostate cancer, but also for other complex uro-oncological cases. The clinic allows optimized oncological treatment without delay and with a reduced effort for patients.
DOI: 10.6084/m9.figshare.8235614.v1
title: Synthetic Hunchback P2 Sequences

description: This file contains sequences of synthetic versions of the Hunchback P2 enhancer, computationally designed to contain only Bicoid binding sites and various amounts of flanking sequence. These synthetic enhancers drive expression in the anterior of the Drosophila blastoderm embryo.
DOI: 10.15156/bio/sh2744762.08fu
title: SH2744762.08FU

description: UNITE provides a unified way for delimiting, identifying, communicating, and working with DNA-based Species Hypotheses (SH). All fungal ITS sequences in the international nucleotide sequence databases are clustered to approximately the species level by applying a set of dynamic distance values (<0.5 - 3.0%). All species hypotheses are given a unique, stable name in the form of a DOI, and their taxonomic and ecological annotations are verified through distributed, web-based third-party annotation efforts. SHs are connected to a taxon name and its classification as far as possible (phylum, class, order, etc.) by taking into account identifications for all sequences in the SH. An automatically or manually designated sequence is chosen to represent each such SH. These sequences are released (https://unite.ut.ee/repository.php) for use by the scientific community in, for example, local sequence similarity searches and next-generation sequencing analysis pipelines. The system and the data are updated automatically as the number of public fungal ITS sequences grows.
DOI: 10.15156/bio/sh2744763.08fu
title: SH2744763.08FU

description: UNITE provides a unified way for delimiting, identifying, communicating, and working with DNA-based Species Hypotheses (SH). All fungal ITS sequences in the international nucleotide sequence databases are clustered to approximately the species level by applying a set of dynamic distance values (<0.5 - 3.0%). All species hypotheses are given a unique, stable name in the form of a DOI, and their taxonomic and ecological annotations are verified through distributed, web-based third-party annotation efforts. SHs are connected to a taxon name and its classification as far as possible (phylum, class, order, etc.) by taking into account identifications for all sequences in the SH. An automatically or manually designated sequence is chosen to represent each such SH. These sequences are released (https://unite.ut.ee/repository.php) for use by the scientific community in, for example, local sequence similarity searches and next-generation sequencing analysis pipelines. The system and the data are updated automatically as the number of public fungal ITS sequences grows.
DOI: 10.15156/bio/sh2744764.08fu
title: SH2744764.08FU

description: UNITE provides a unified way for delimiting, identifying, communicating, and working with DNA-based Species Hypotheses (SH). All fungal ITS sequences in the international nucleotide sequence databases are clustered to approximately the species level by applying a set of dynamic distance values (<0.5 - 3.0%). All species hypotheses are given a unique, stable name in the form of a DOI, and their taxonomic and ecological annotations are verified through distributed, web-based third-party annotation efforts. SHs are connected to a taxon name and its classification as far as possible (phylum, class, order, etc.) by taking into account identifications for all sequences in the SH. An automatically or manually designated sequence is chosen to represent each such SH. These sequences are released (https://unite.ut.ee/repository.php) for use by the scientific community in, for example, local sequence similarity searches and next-generation sequencing analysis pipelines. The system and the data are updated automatically as the number of public fungal ITS sequences grows.
DOI: 10.26093/cds/vizier.51590090
title: Li, C and O abundances of FGK stars

description: VizieR online Data Catalogue associated with article published in journal Astronomical Journal (AAS) with title 'High-resolution spectroscopic study of dwarf stars in the northern sky: lithium, carbon, and oxygen abundances.' (bibcode: 2020AJ....159...90S)
DOI: 10.15156/bio/sh2744765.08fu
title: SH2744765.08FU

description: UNITE provides a unified way for delimiting, identifying, communicating, and working with DNA-based Species Hypotheses (SH). All fungal ITS sequences in the international nucleotide sequence databases are clustered to approximately the species level by applying a set of dynamic distance values (<0.5 - 3.0%). All species hypotheses are given a unique, stable name in the form of a DOI, and their taxonomic and ecological annotations are verified through distributed, web-based third-party annotation efforts. SHs are connected to a taxon name and its classification as far as possible (phylum, class, order, etc.) by taking into account identifications for all sequences in the SH. An automatically or manually designated sequence is chosen to represent each such SH. These sequences are released (https://unite.ut.ee/repository.php) for use by the scientific community in, for example, local sequence similarity searches and next-generation sequencing analysis pipelines. The system and the data are updated automatically as the number of public fungal ITS sequences grows.
DOI: 10.15156/bio/sh2744766.08fu
title: SH2744766.08FU

description: UNITE provides a unified way for delimiting, identifying, communicating, and working with DNA-based Species Hypotheses (SH). All fungal ITS sequences in the international nucleotide sequence databases are clustered to approximately the species level by applying a set of dynamic distance values (<0.5 - 3.0%). All species hypotheses are given a unique, stable name in the form of a DOI, and their taxonomic and ecological annotations are verified through distributed, web-based third-party annotation efforts. SHs are connected to a taxon name and its classification as far as possible (phylum, class, order, etc.) by taking into account identifications for all sequences in the SH. An automatically or manually designated sequence is chosen to represent each such SH. These sequences are released (https://unite.ut.ee/repository.php) for use by the scientific community in, for example, local sequence similarity searches and next-generation sequencing analysis pipelines. The system and the data are updated automatically as the number of public fungal ITS sequences grows.
DOI: 10.15156/bio/sh2744767.08fu
title: SH2744767.08FU

description: UNITE provides a unified way for delimiting, identifying, communicating, and working with DNA-based Species Hypotheses (SH). All fungal ITS sequences in the international nucleotide sequence databases are clustered to approximately the species level by applying a set of dynamic distance values (<0.5 - 3.0%). All species hypotheses are given a unique, stable name in the form of a DOI, and their taxonomic and ecological annotations are verified through distributed, web-based third-party annotation efforts. SHs are connected to a taxon name and its classification as far as possible (phylum, class, order, etc.) by taking into account identifications for all sequences in the SH. An automatically or manually designated sequence is chosen to represent each such SH. These sequences are released (https://unite.ut.ee/repository.php) for use by the scientific community in, for example, local sequence similarity searches and next-generation sequencing analysis pipelines. The system and the data are updated automatically as the number of public fungal ITS sequences grows.
DOI: 10.15156/bio/sh2744768.08fu
title: SH2744768.08FU

description: UNITE provides a unified way for delimiting, identifying, communicating, and working with DNA-based Species Hypotheses (SH). All fungal ITS sequences in the international nucleotide sequence databases are clustered to approximately the species level by applying a set of dynamic distance values (<0.5 - 3.0%). All species hypotheses are given a unique, stable name in the form of a DOI, and their taxonomic and ecological annotations are verified through distributed, web-based third-party annotation efforts. SHs are connected to a taxon name and its classification as far as possible (phylum, class, order, etc.) by taking into account identifications for all sequences in the SH. An automatically or manually designated sequence is chosen to represent each such SH. These sequences are released (https://unite.ut.ee/repository.php) for use by the scientific community in, for example, local sequence similarity searches and next-generation sequencing analysis pipelines. The system and the data are updated automatically as the number of public fungal ITS sequences grows.
DOI: 10.26093/cds/vizier.51590092
title: Yarkovsky drift measurements for NEAs

description: VizieR online Data Catalogue associated with article published in journal Astronomical Journal (AAS) with title 'Yarkovsky drift detections for 247 Near-Earth Asteroids.' (bibcode: 2020AJ....159...92G)
DOI: 10.15156/bio/sh2744769.08fu
title: SH2744769.08FU

description: UNITE provides a unified way for delimiting, identifying, communicating, and working with DNA-based Species Hypotheses (SH). All fungal ITS sequences in the international nucleotide sequence databases are clustered to approximately the species level by applying a set of dynamic distance values (<0.5 - 3.0%). All species hypotheses are given a unique, stable name in the form of a DOI, and their taxonomic and ecological annotations are verified through distributed, web-based third-party annotation efforts. SHs are connected to a taxon name and its classification as far as possible (phylum, class, order, etc.) by taking into account identifications for all sequences in the SH. An automatically or manually designated sequence is chosen to represent each such SH. These sequences are released (https://unite.ut.ee/repository.php) for use by the scientific community in, for example, local sequence similarity searches and next-generation sequencing analysis pipelines. The system and the data are updated automatically as the number of public fungal ITS sequences grows.