cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.7509704
title: The thyroid hormone receptor β-selective agonist GC-1 does not affect tolerance to exercise in hypothyroid rats

description: Objective Investigate the effect of GC-1 on tolerance to exercise in rats with experimental hypothyroidism. Materials and methods Hypothyroidism was induced with methimazole sodium and perchlorate treatment. Six groups with eight animals were studied: control group (C), hypothyroid group without treatment (HYPO); hypothyroidism treated with physiological doses of tetraiodothyronine (T4) or 10 times higher (10×T4); hypothyroidism treated with equal molar doses of GC-1 (GC-1) or 10 times higher (10×GC-1). After eight weeks, each animal underwent an exercise tolerance test by measuring the time (seconds), in which the rats were swimming with a load attached to their tails without being submerging for more than 10 sec. After the test, the animals were killed, and blood samples were collected for biochemical analysis, and the heart and soleus muscle were removed for weighing and morphometric analysis of the cardiomyocyte. Results Hypothyroidism significantly reduced tolerance to exercise and, treatment with GC-1 1× or T4 in physiological doses recover tolerance test to normal parameters. However, high doses of T4 also decreased tolerance to physical exercise. Conversely, ten times higher doses of GC-1 did not impair tolerance to exercise. Interestingly, hypothyroidism, treated or not with T4 in a physiological range, GC-1 or even high doses of GC-1 (10X) did not change cardiomyocyte diameters and relative weight of the soleus muscle. In contrast, higher doses of T4 significantly increased cardiomyocyte diameter and induced atrophy of the soleus muscle. Conclusion Unlike T4, GC-1 in high doses did not modify tolerance to physical exercise in the rats with hypothyroidism.
DOI: 10.7284/132669
title: ADCP (Acoustic Doppler Current Profiler) data collected during research cruise KM1907 using a Hawaii UHDAS instrument system onboard the platform RV Kilo Moana

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7509704.v1
title: The thyroid hormone receptor β-selective agonist GC-1 does not affect tolerance to exercise in hypothyroid rats

description: Objective Investigate the effect of GC-1 on tolerance to exercise in rats with experimental hypothyroidism. Materials and methods Hypothyroidism was induced with methimazole sodium and perchlorate treatment. Six groups with eight animals were studied: control group (C), hypothyroid group without treatment (HYPO); hypothyroidism treated with physiological doses of tetraiodothyronine (T4) or 10 times higher (10×T4); hypothyroidism treated with equal molar doses of GC-1 (GC-1) or 10 times higher (10×GC-1). After eight weeks, each animal underwent an exercise tolerance test by measuring the time (seconds), in which the rats were swimming with a load attached to their tails without being submerging for more than 10 sec. After the test, the animals were killed, and blood samples were collected for biochemical analysis, and the heart and soleus muscle were removed for weighing and morphometric analysis of the cardiomyocyte. Results Hypothyroidism significantly reduced tolerance to exercise and, treatment with GC-1 1× or T4 in physiological doses recover tolerance test to normal parameters. However, high doses of T4 also decreased tolerance to physical exercise. Conversely, ten times higher doses of GC-1 did not impair tolerance to exercise. Interestingly, hypothyroidism, treated or not with T4 in a physiological range, GC-1 or even high doses of GC-1 (10X) did not change cardiomyocyte diameters and relative weight of the soleus muscle. In contrast, higher doses of T4 significantly increased cardiomyocyte diameter and induced atrophy of the soleus muscle. Conclusion Unlike T4, GC-1 in high doses did not modify tolerance to physical exercise in the rats with hypothyroidism.
DOI: 10.7284/132674
title: Barometer data collected during research cruise KM1907 using a Vaisala PTB220 instrument system onboard the platform RV Kilo Moana

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/132672
title: Fluorometer data collected during research cruise KM1907 using a WET Labs WETStar instrument system onboard the platform RV Kilo Moana

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/132673
title: Fluorometer data collected during research cruise KM1907 using a Turner 10-AU instrument system onboard the platform RV Kilo Moana

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7509674
title: São Paulo’s Azores house: immigration, associativism and religiosity

description: abstract This research focuses on the experiences of the Azorean immigrants in the city of São Paulo, in particular, their associative practice in the Casa dos Açores de São Paulo (Casp), observing their historicity, daily life, recreational and assistance activities, as well as actions aimed at maintaining the traditions, memories, religiosity and festivities such as the Divine Holy Spirit, one of the icons of this group of immigrants.
DOI: 10.6084/m9.figshare.7509668
title: Systematic molecular analysis of hemophilia A patients from Colombia

description: Abstract Hemophilia A (HA) is an X-linked recessive disorder and the second most common coagulation disorder with an incidence of 1 in 5,000 live born males. Worldwide, there are 178,500 affected individuals, 60% with the severe form of the disease. Intron 22 and 1 inversions (Inv22 and Inv1) are the most frequent molecular alterations found in severe HA patients with a frequency of 45-50% and 0.5-5%, respectively. We have implemented a systematic cost-effective strategy for the identification of the molecular alteration in HA patients using Inverse shifting-PCR for Inv22 and Inv1, followed by the analysis of the F8 gene coding region by means of high resolution melting (HRM) PCR and Sanger sequencing in Inv22 and Inv1 negative patients. A total of 33 male HA patients and 6 women were analyzed. Inversion 22 was detected in 14/33 male patients (42.4%), 3/33 (9.1%) had Inv1, 3/33 (9.1%) had large structural variants, and 11/33 (33.3%) single nucleotide/ small frameshift variants. No genetic variant was found in 2/33 patients (6%). With this systematic approach we detected pathogenic variants in 31 out of 33 male affected individuals (94%) tested for the first time.in a cohort of patients from Colombia.
DOI: 10.6084/m9.figshare.7509674.v1
title: São Paulo’s Azores house: immigration, associativism and religiosity

description: abstract This research focuses on the experiences of the Azorean immigrants in the city of São Paulo, in particular, their associative practice in the Casa dos Açores de São Paulo (Casp), observing their historicity, daily life, recreational and assistance activities, as well as actions aimed at maintaining the traditions, memories, religiosity and festivities such as the Divine Holy Spirit, one of the icons of this group of immigrants.
DOI: 10.7284/132670
title: Gravimeter data collected during research cruise KM1907 using a Bell BGM-3 instrument system onboard the platform RV Kilo Moana

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7509668.v1
title: Systematic molecular analysis of hemophilia A patients from Colombia

description: Abstract Hemophilia A (HA) is an X-linked recessive disorder and the second most common coagulation disorder with an incidence of 1 in 5,000 live born males. Worldwide, there are 178,500 affected individuals, 60% with the severe form of the disease. Intron 22 and 1 inversions (Inv22 and Inv1) are the most frequent molecular alterations found in severe HA patients with a frequency of 45-50% and 0.5-5%, respectively. We have implemented a systematic cost-effective strategy for the identification of the molecular alteration in HA patients using Inverse shifting-PCR for Inv22 and Inv1, followed by the analysis of the F8 gene coding region by means of high resolution melting (HRM) PCR and Sanger sequencing in Inv22 and Inv1 negative patients. A total of 33 male HA patients and 6 women were analyzed. Inversion 22 was detected in 14/33 male patients (42.4%), 3/33 (9.1%) had Inv1, 3/33 (9.1%) had large structural variants, and 11/33 (33.3%) single nucleotide/ small frameshift variants. No genetic variant was found in 2/33 patients (6%). With this systematic approach we detected pathogenic variants in 31 out of 33 male affected individuals (94%) tested for the first time.in a cohort of patients from Colombia.
DOI: 10.7284/132671
title: Gyrocompass data collected during research cruise KM1907 using a Sperry NAVIGAT X MK 1 instrument system onboard the platform RV Kilo Moana

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7509650
title: Molecular genotyping of G6PD mutations and Duffy blood group in Afro-descendant communities from Brazilian Amazon

description: Abstract Glucose-6-phosphate dehydrogenase deficiency (G6PDd) and Duffy-negative blood group are two red blood cells variants that confer protection against malaria. In this study, the distribution of the most common G6PD variants (G6PD*A-, GGPD*A and G6PD Mediterranean) and the major alleles of the Duffy blood group (FY*A, FY*B and FY*BES) were investigated in an Afro-descendant population from state of Pará, Brazilian Amazon. G6PD variants and Duffy blood group alleles were determined by TaqMan SNP genotyping assay. Overall, molecular genotyping revealed the presence of G6PD variants in 126 (24%) of the individuals studied (5% male and 19% female), and frequencies of the G6PD*A- and G6PD*A alleles were 0.061 and 0.104, respectively. Duffy blood group genotyping showed that 24.3% of people were Duffy-negative and 41.3% were heterozygous for FY*BES. The frequency of allele FY*BES was 41.0%. The results emphasize the need to monitor G6PD deficiency for the use of primaquine in the routine care of the Afro-descendant communities of the Trombetas, Erepecuru and Cumná rivers, evaluating the risks of hemolytic crisis in case of recurrence of malaria in the region. In addition, the possible greater protection against malaria conferred by these erythrocyte polymorphisms deserves to be better investigated and explored among these Afro-descendants.
DOI: 10.6084/m9.figshare.7509650.v1
title: Molecular genotyping of G6PD mutations and Duffy blood group in Afro-descendant communities from Brazilian Amazon

description: Abstract Glucose-6-phosphate dehydrogenase deficiency (G6PDd) and Duffy-negative blood group are two red blood cells variants that confer protection against malaria. In this study, the distribution of the most common G6PD variants (G6PD*A-, GGPD*A and G6PD Mediterranean) and the major alleles of the Duffy blood group (FY*A, FY*B and FY*BES) were investigated in an Afro-descendant population from state of Pará, Brazilian Amazon. G6PD variants and Duffy blood group alleles were determined by TaqMan SNP genotyping assay. Overall, molecular genotyping revealed the presence of G6PD variants in 126 (24%) of the individuals studied (5% male and 19% female), and frequencies of the G6PD*A- and G6PD*A alleles were 0.061 and 0.104, respectively. Duffy blood group genotyping showed that 24.3% of people were Duffy-negative and 41.3% were heterozygous for FY*BES. The frequency of allele FY*BES was 41.0%. The results emphasize the need to monitor G6PD deficiency for the use of primaquine in the routine care of the Afro-descendant communities of the Trombetas, Erepecuru and Cumná rivers, evaluating the risks of hemolytic crisis in case of recurrence of malaria in the region. In addition, the possible greater protection against malaria conferred by these erythrocyte polymorphisms deserves to be better investigated and explored among these Afro-descendants.
DOI: 10.7284/132667
title: INS (Inertial Navigation System) data collected during research cruise KM1907 using a Applanix POS/MV-320 V4 instrument system onboard the platform RV Kilo Moana

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/132668
title: Meteorological Station data collected during research cruise KM1907 using a Campbell CR3000 instrument system onboard the platform RV Kilo Moana

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/132675
title: Meteorological Station data collected during research cruise KM1907 using a Campbell CR3000 instrument system onboard the platform RV Kilo Moana

description: Processed data created by vessel technician during a Field_expedition
DOI: 10.7284/132666
title: Speedlog data collected during research cruise KM1907 using a Yokogawa EML500FA2 instrument system onboard the platform RV Kilo Moana

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/132665
title: SSV (Sound Speed Velocimeter) data collected during research cruise KM1907 using a AML SV&P instrument system onboard the platform RV Kilo Moana

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/132664
title: TSG (Thermosalinograph) data collected during research cruise KM1907 using a Sea-Bird SBE-45 instrument system onboard the platform RV Kilo Moana

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/132899
title: ADCP (Acoustic Doppler Current Profiler) data collected during research cruise KM1909 using a Hawaii UHDAS instrument system onboard the platform RV Kilo Moana

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/132904
title: Barometer data collected during research cruise KM1909 using a Vaisala PTB220 instrument system onboard the platform RV Kilo Moana

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/132902
title: Fluorometer data collected during research cruise KM1909 using a WET Labs WETStar instrument system onboard the platform RV Kilo Moana

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/132903
title: Fluorometer data collected during research cruise KM1909 using a Turner 10-AU instrument system onboard the platform RV Kilo Moana

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7509557
title: Risk factors for elective laparoscopic cholecystectomy morbimortality in elderly.

description: ABSTRACT Objective: to identify risk factors for the occurrence of postoperative complications in laparoscopic cholecystectomies (LC) in elderly patients. Methods: an observational study with analysis of medical records of patients aged 60 years and older, submitted to elective LC at Gaffree e Guinle Universitary Hospital, from 2006 to 2018. Surgeries performed on an emergency basis or converted to the conventional technique were excluded from our study. Results: a total of 345 patients were included in our study, being 80% females and 62% aged 60-69 years. There were 39 cases of postoperative complications (11.3%), mostly (87%) classified as grades I or II of Clavien-Dindo surgical complication scale. There was only one death. The presence and the number of coexisting diseases and ASA II or III physical status classification of preoperative patients conferred a greater risk for the development of postoperative complications and mortality. Conclusion: our study identified the presence of coexisting diseases, as well as their severity, according to ASA classification, as risk factors for the development of postoperative complications of LC in elderly patients. However, LC proved to be a safe technique when used in these patients with low morbidity and mortality rates.
DOI: 10.7284/132900
title: Gravimeter data collected during research cruise KM1909 using a Bell BGM-3 instrument system onboard the platform RV Kilo Moana

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7509557.v1
title: Risk factors for elective laparoscopic cholecystectomy morbimortality in elderly.

description: ABSTRACT Objective: to identify risk factors for the occurrence of postoperative complications in laparoscopic cholecystectomies (LC) in elderly patients. Methods: an observational study with analysis of medical records of patients aged 60 years and older, submitted to elective LC at Gaffree e Guinle Universitary Hospital, from 2006 to 2018. Surgeries performed on an emergency basis or converted to the conventional technique were excluded from our study. Results: a total of 345 patients were included in our study, being 80% females and 62% aged 60-69 years. There were 39 cases of postoperative complications (11.3%), mostly (87%) classified as grades I or II of Clavien-Dindo surgical complication scale. There was only one death. The presence and the number of coexisting diseases and ASA II or III physical status classification of preoperative patients conferred a greater risk for the development of postoperative complications and mortality. Conclusion: our study identified the presence of coexisting diseases, as well as their severity, according to ASA classification, as risk factors for the development of postoperative complications of LC in elderly patients. However, LC proved to be a safe technique when used in these patients with low morbidity and mortality rates.
DOI: 10.7284/132901
title: Gyrocompass data collected during research cruise KM1909 using a Sperry NAVIGAT X MK 1 instrument system onboard the platform RV Kilo Moana

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/132897
title: INS (Inertial Navigation System) data collected during research cruise KM1909 using a Applanix POS/MV-320 V4 instrument system onboard the platform RV Kilo Moana

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/132898
title: Meteorological Station data collected during research cruise KM1909 using a Campbell CR3000 instrument system onboard the platform RV Kilo Moana

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/132905
title: Meteorological Station data collected during research cruise KM1909 using a Campbell CR3000 instrument system onboard the platform RV Kilo Moana

description: Processed data created by vessel technician during a Field_expedition
DOI: 10.7284/132896
title: Speedlog data collected during research cruise KM1909 using a Yokogawa EML500FA2 instrument system onboard the platform RV Kilo Moana

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/132895
title: SSV (Sound Speed Velocimeter) data collected during research cruise KM1909 using a AML SV&P instrument system onboard the platform RV Kilo Moana

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/132894
title: TSG (Thermosalinograph) data collected during research cruise KM1909 using a Sea-Bird SBE-45 instrument system onboard the platform RV Kilo Moana

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/134222
title: ADCP (Acoustic Doppler Current Profiler) data collected during research cruise KM1910 using a Hawaii UHDAS instrument system onboard the platform RV Kilo Moana

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/134228
title: Barometer data collected during research cruise KM1910 using a Vaisala PTB220 instrument system onboard the platform RV Kilo Moana

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/134223
title: CTD (Conductivity, Temperature, Depth) data collected during research cruise KM1910 using a Sea-Bird SBE-911+ instrument system onboard the platform RV Kilo Moana

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/134226
title: Fluorometer data collected during research cruise KM1910 using a WET Labs WETStar instrument system onboard the platform RV Kilo Moana

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/134227
title: Fluorometer data collected during research cruise KM1910 using a Turner 10-AU instrument system onboard the platform RV Kilo Moana

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/134224
title: Gravimeter data collected during research cruise KM1910 using a Bell BGM-3 instrument system onboard the platform RV Kilo Moana

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/134225
title: Gyrocompass data collected during research cruise KM1910 using a Sperry NAVIGAT X MK 1 instrument system onboard the platform RV Kilo Moana

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/134220
title: INS (Inertial Navigation System) data collected during research cruise KM1910 using a Applanix POS/MV-320 V4 instrument system onboard the platform RV Kilo Moana

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7509413
title: The power in the nurse-patient relationship: integrative review

description: Abstract An integrative literature review was performed by searching seven of the main electronic health databases order to describe and analyse the production of knowledge about the power in nursing care relationships to hospitalised patients. According to the established criteria, 10 articles were selected from the year 2000 to September 2015. The analysis of these data evidenced that the scientific knowledge and the hospital routines and norms are instruments of exercise of power that end up violating the identity of the person who is transformed into a patient. However, the studies revealed that nursing professionals do not always perceive themselves as exercising power over patients, arguing that they act according to the needs diagnosed care, prescribing interventions, not always agreed with the patients, but resolutive. In short, nursing professionals need to reflect on their work processes to perceive themselves as care professionals and to guarantee the space for autonomy.
DOI: 10.6084/m9.figshare.7509413.v1
title: The power in the nurse-patient relationship: integrative review

description: Abstract An integrative literature review was performed by searching seven of the main electronic health databases order to describe and analyse the production of knowledge about the power in nursing care relationships to hospitalised patients. According to the established criteria, 10 articles were selected from the year 2000 to September 2015. The analysis of these data evidenced that the scientific knowledge and the hospital routines and norms are instruments of exercise of power that end up violating the identity of the person who is transformed into a patient. However, the studies revealed that nursing professionals do not always perceive themselves as exercising power over patients, arguing that they act according to the needs diagnosed care, prescribing interventions, not always agreed with the patients, but resolutive. In short, nursing professionals need to reflect on their work processes to perceive themselves as care professionals and to guarantee the space for autonomy.
DOI: 10.7284/134221
title: Meteorological Station data collected during research cruise KM1910 using a Hawaii MET-System instrument system onboard the platform RV Kilo Moana

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/134229
title: Meteorological Station data collected during research cruise KM1910 using a Hawaii MET-System instrument system onboard the platform RV Kilo Moana

description: Processed data created by vessel technician during a Field_expedition
DOI: 10.7284/134219
title: Speedlog data collected during research cruise KM1910 using a Yokogawa EML500FA2 instrument system onboard the platform RV Kilo Moana

description: Original (unprocessed) data collected during a Field_expedition