cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.17632/7thk5fhysn
title: Tetrahydrobenzimidazole TMQ0153 triggers apoptosis, autophagy and necroptosis crosstalk in chronic myeloid leukemia (Part 3 Figure 5-9, Supple 1-12))

description: Abstract Chronic myeloid leukemia (CML) results from a t(9;22) (q34; q11) translocation, also called Philadelphia chromosome (Ph). This reciprocal translocation causes a constitutively-activated tyrosine kinase BCR-ABL fusion gene. By comparing imatinib-sensitive and -resistant CML cell models, we investigated the molecular mechanisms by which tetrahydrobenzimidazole derivative TMQ0153 triggered caspase-dependent apoptosis at low concentrations accompanied by loss of mitochondrial membrane potential (MMP) and increase of cytosolic free Ca2+ levels. Interestingly, at higher concentrations, TMQ0153 induced necroptotic cell death with accumulation of ROS, both preventable by N-acetyl-L-cysteine (NAC) pretreatment. At necroptosis-inducing concentrations, we observed increased ROS and decreased ATP and GSH levels, concomitant with protective autophagy induction. Inhibitors such as bafilomycin A1 (baf-A1) and siRNA against beclin 1 abrogated autophagy, sensitized CML cells against TMQ0153 and enhanced necroptotic cell death. Importantly, TMQ153-induced necrosis led to cell surface exposure of calreticulin (CRT) and ERp57 as well as the release of extracellular ATP and high mobility group box (HMGB1) demonstrating the immunological cell death markers by TMQ0153. We validated the anti-cancer potential of TMQ0153 by in vivo inhibition of K562 microtumor formation in zebrafish. Taken together, our findings provide evidence that cellular stress and redox modulation by TMQ0153 concentration-dependently leads to different cell death modalities including controlled necrosis in CML cell models.
DOI: 10.6084/m9.figshare.1170110.v5
title: Salmonella Typhi H58 MinION and Illumina data

description: Here, we report the use of the MinION to resolve the structure of a composite transposon, encoding multidrug resistance, in Salmonella Typhi Haplotype 58 - a multidrug resistant strain that has undergone global expansion. MinION data from a single 18-hour run was used to scaffold Illumina data and identify the chromosomal insertion site and structure of the island.
DOI: 10.6084/m9.figshare.21001849.v1
title: Neogene burial of organic carbon in the global ocean

description: The global rate of OC burial is conventionally established by using the mass balance between inorganic and organic carbon, each with distinct isotopic values (δ<sup>13</sup>C). However, this method is complicated by major uncertainties associated with some key parameters. Here we report a “bottom up” approach independent from mass balance calculations, by using data from 81 globally distributed IODP/ODP/DSDP sites covering all major ocean basins and sedimentary environments, to establish regional and global history of OC burial over the Neogene (~23 – 3 million years ago). Our results show large spatiotemporal variability of OC burial, suggesting that it plays a much more important role in regulating the carbon cycle than previously thought. Globally, the burial was higher towards the early Miocene and Pliocene, but lowest during the mid-Miocene.The enriched carbonate δ<sup>13</sup>C during the mid-Miocene is more likely related to shifts to a volcanic-dominated source of carbon into the Earth’s surficial system,which turns the interpretation of OC burial during the Miocene on its head and demands a reconsideration of the Monterey Hypothesis and the necessity to rethink some of the fundamentals of the global carbon cycle. This dataset contains the calculation process of global organic carbon burial fluxes over the Neogene (23.0-2.6 Ma) period. The mass accumulation rates (MARs) of organic carbon (OC) were calculated for each site based on sedimentation rate, bulk density, and TOC%, and were used to determine the spatial and temporal variability of OC burial in the Neogene.
DOI: 10.6084/m9.figshare.28974224.v1
title: Supplementary materials for The climate niche pressure predominates the diversification of advertisement calls in frogs (<i>Leptobrachella</i>)

description: Supplementary materials for The climate niche pressure predominates the diversification of advertisement calls in frogs (<i>Leptobrachella</i>). The dataset contains data from three aspects: phylogenetics, bioacoustics, and ecology.
DOI: 10.6084/m9.figshare.21739850.v1
title: Annual values of snow season length

description: This file contains annual values of snow season length for 1950-2021 in GeoTIFF format.
DOI: 10.6084/m9.figshare.24995828.v1
title: Data sources and raw data.xlsx

description: To facilitate a comprehensive analysis of the spatial settings of geopolitical risk, we have developed an evaluation index system for geopolitical risk, grounded in the multi-scale risk perception framework. Using this system of evaluation indicators, we calculated the geopolitical risk for nine countries in Southeast Asia for the period 2013-2021. The dataset contains sources and raw data for the relevant indicators.
DOI: 10.6084/m9.figshare.5150443.v1
title: Missing in action: species competition is a neglected predictor variable in Species Distribution Modelling _Raw_Data

description: Presence data for buffalo (n = 93), warthog (n = 27), waterbuck (n =21), wildebeest (n = 24) and zebra (n =44) were collected via an aerial survey conducted in Gonarezhou National Park in October 2013. The aerial survey was a sample with transects spaced at 1.5 km and 2.5 km depending on animal density within sampling strata. A Cessna 185 fixed wing plane was used and two observers sitting at the right and left sides of the plane observed animals within strips of width 150 m. The observers searched for animals between two streamers fitted to the wing struts of the plane during pre-calibration flights in such a way that the search strip on the ground was 150 m wide. Each time animals were sighted, the location of the sighting was marked using a handheld GPS device (GPSmap 296, Garmin international). A full description of the method is provided in 'Norton-Griffiths M (1978) Counting animals. Handbooks on techniques currently used in African wildlife ecology. African Wildlife Leadership Foundation, Nairobi'.
DOI: 10.17632/t6s7pcdsyw
title: Data and programs for "Liquidity Regulation and Banks: Theory and Evidence"

description: Data and programs for "Liquidity Regulation and Banks: Theory and Evidence"
DOI: 10.6084/m9.figshare.20264391.v2
title: Standard curves

description: Standard curves used for bacterial quantification using qPCR
DOI: 10.6084/m9.figshare.5271712.v2
title: Experimental demonstration that offspring fathered by old males have shorter telomeres and reduced lifespan

description: Database for the manuscript Noguera et al. PRSB
DOI: 10.17632/58yntjyhh2
title: Understanding the Interplay Between Stress, Anxiety, and Depression and Their Impact on Health in Traffic Police Officers: A Structural Equation Modeling Study (Dataset)

description: Background: Traffic police officers are frequently exposed to stress, anxiety, and depression, which adversely impact their health. This study hypothesized that these factors influence the hormonal, muscular, digestive, and cognitive systems of traffic police officers. Methods: The sample comprised 146 traffic police officers (42 women and 104 men) aged 30 to 38. Gender differences in symptoms were examined, and model fit was assessed using indicators such as chi-square, comparative fit index, root mean square error of approximation (RMSEA), and standardized root means residual (SRMR). Results: Gender differences were observed, with women reporting more significant issues related to muscular, hormonal, and cognitive symptoms. The models demonstrated a good fit, particularly in the model examining digestive symptoms. Conclusions: The findings indicate a substantial impact of stress, anxiety, and depression on traffic police officers' health. Psychological support and monitoring are recommended at traffic police stations. The results align with previous research and underscore the need for targeted interventions to address the health challenges faced by these specialized police groups exposed to daily stressors.
DOI: 10.17632/h4m6r24vy8
title: Emotional Schemas Raw Data

description: Two mediation models were tested through Structural equation modelling (SEM) in which the effects of childhood maltreatment and the mediator variables (emotional schemas and psychological inflexibility) on emotional distress were assessed. The sexual abuse subscale of the CTQ wasn’t predicted by the total scale and thus was eliminated from the model. The remaining subscales were used as manifest indicators for the childhood maltreatment latent variable in both models. Again in both models, there were two mediator variables: negative beliefs about emotion was modeled as a latent variable with LESS-II as the indicator; and psychological inflexibility/experiential avoidance was modeled as a latent variable with AAQ-II as the indicator. In the first model, DASS-21 total scale was used as an indicator for emotional distress latent variable, and in the second model depression, anxiety, and stress subscales of DASS-21 were used distinctively as indicators of the emotional distress latent variable.
DOI: 10.6084/m9.figshare.29095397.v1
title: Definición de categorías

description: En este documento se encuentra la definición de las categorías y subcategorías diseñadas, y un ejemplo de cómo se utiliza dicha categoría para codificar diferentes segmentos de nuestra investigación. Posteriormente está la tabla que presenta la unidad de análisis, las categorías y subcategorías y sus definiciones generadas para realizar la codificación del conocimiento conceptual y procedimental.
DOI: 10.1184/r1/14456124
title: BOLD5000 Release 2.0

description: BOLD5000 Release 2.0 is a complete re-release of functional data from BOLD5000, with optimized procedures for GLM estimation of brain-wide percent signal change in response to the experimental stimuli, yielding significant increases in the reliability of BOLD signal estimates compared to the initial data release.<br> For documentation and processing scripts, see: https://github.com/BOLD5000-dataset/BOLD5000<br>For related materials see the BOLD5000 Collection at https://doi.org/10.1184/R1/c.5325683<br>
DOI: 10.6084/m9.figshare.11799342.v1
title: SI - Vlaeminck et al. (2020) - Raw data 2

description: Supplemental information to Vlaeminck et al. (2020 - draft): "Validation of a mixture toxicity implementation in DEB-IBM: effects of copper and zinc on Daphnia magna populations."<br>Raw data on a population experiment with Dapnia magna populations exposed to mixtures of copper and zinc.
DOI: 10.17632/ny8rgnmw37
title: Replication data for "Fiscal decentralization and social sector spending: The role of women’s political representation and gender quotas"

description: This data file contains clean data and information on variables related to fiscal decentralization, women's political representation, empowerment, political regimes, and health and education spending. The dataset has been compiled by combining data from multiple sources, including IMF-GFS, World Development Indicators, and V-Dem, among others. This dataset has been used to examine the impact of fiscal decentralization on social sector spending, considering the role of women's political representation as analyzed in our paper. Additionally, the influence of gender quotas has been explored. The dataset is an unbalanced panel spanning the period 2000–2019 for 54 countries. It is sufficient to replicate all the results presented in the study. Using this data, we tested our hypothesis. We found a positive association between fiscal decentralization and social sector spending (health and education spending), which is further enhanced by a higher proportion of women in national parliaments.
DOI: 10.6084/m9.figshare.16818415.v1
title: GeoMx DSP project- pT1 CRC

description: GeoMx Digital Spatial Profiling gene expression data corresponding to manuscript "<strong>Transcriptomic and immunophenotypic profiling reveals molecular and immunological hallmarks of colorectal cancer tumorigenesis</strong>".
DOI: 10.17632/h8jsf45skc
title: SiC-1SSF-MLFF

description: Trained MLFF to simulate 1SSFs in 4H-SiC. See "Machine-learning enhanced thermal stability investigation of single Shockley stacking faults in 4H-SiC" for details.
DOI: 10.17632/ws58h3crzh
title: LC-MS/MS measurements of ketoacids isotopologues distribution in HeLa cells after 90 min of intramitochondrial pyruvate influx by Grubraw

description: We analysed 13C metabolic inclusion into ketoacids in HeLa cell lines stably expressing Pseudomonas aeruginosa DadA (FAD-dependent D-amino acid dehydrogenase) gene with mitochondrial targeting (named Grubraw) after the addition of 12C D-alanine comparing to no D-alanine. We used HeLa cell lines with functional DadA and mutated DadA for control. In cells expressing functionally active DadA, D-alanine generates additional influx of intra-mitochondrial pyruvate. If cells grows on labelled carbone source and unlabeled D-alanine is used, this upcoming pyruvate shifts original mass-isotopologue distribution that can be registered by LC-MS. Our cells were cultured for in a medium with labeled glucose or glutamine. To obtain current data, we changed rich growth media to pure phosphate medium containing labeled carbon substrate (with only labeled glucose, or a mixture of glucose and glutamine with only one labeled component), added D-alanine, and incubated cells under these conditions for 90 minutes before extraction. Using this scheme, we focused on acute effects of Grubraw activation. We publish original RAW data from Orbitrap mass-spectrometer of intra- and extracellular ketoacid analysis. In “G” folders we put experiments with glucose as the only carbon source. In “GQ” folders, there are measurements for glucose+glutamine experiments. All files are named in a similar way. C12/C13 in the beginning indicates using of isotopically labeled carbon source or non-labeled one. “M”/“D” at the second position indicate using a cell line with mutated (M) or functional (D) DadA. “Plus”/“minus” indicates the addition of D-alanine. G/Q in the end of files inside “GQ” folder indicate the experiment with labelled glucose or glutamine correspondingly (the other source is unlabelled). First number is a biological replicate, second number - technical replicate.
DOI: 10.6084/m9.figshare.3530621.v1
title: Appendix B. Residual correlograms of four methods of spatial regression.

description: Residual correlograms of four methods of spatial regression.
DOI: 10.6084/m9.figshare.27291462.v1
title: Appendix tables to paper titled <b>Do women pay for working from home? Exploring gender gaps in pay and wellbeing by work location in the UK Cohort Studies</b>

description: Working from home has seen a rise in prevalence, particularly in the wake of the covid-19 pandemic. Although it is widely believed that wfh enables employees to better combine paid work with domestic duties, potentially enhancing work-life balance, emerging evidence suggests that it may also hinder career advancement and adversely affect mental health, with notable impacts on women. We employ longitudinal data from three British Cohort Studies, collected one year into the covid-19 pandemic, to investigate the characteristics of those who report working from home and the relationship with gender disparities in hourly wages, mental health, and well-being. Using longitudinal data also allows us to control for cohort members’ labour market situation prior to the pandemic, thereby helping to isolate the pandemic’s effects. Our findings indicate that individuals who work from home typically receive higher wages compared to those who work from employers’ premises, but the gender wage gap is most pronounced among those who work from home. Furthermore, consistent with the flexibility paradox, our analysis reveals that women who work from home - particularly those who work hybrid - experience the most detrimental mental health outcomes.
DOI: 10.6084/m9.figshare.23514048.v1
title: Global Dike-Pond System Dataset (1984-2020)

description: <br>The global dike-pond system dataset was generated using a deep learning-based method based on the Global Surface Water dataset. The dataset includes polygons of dike-pond systems for three periods (1984-2000, 2001-2010, and 2011-2020), along with the maximum extent from 1984 to 2020 and the maximum extent of coastal dike-pond systems. Inland dike-pond systems can be derived by excluding coastal ones from the total dike-pond systems. Each polygon is formatted within a 10° x 10° grid, with the latitude and longitude of the upper left corner recored in the filename.
DOI: 10.6084/m9.figshare.27134661.v6
title: Extended Dataset for “Carbapenem-resistant Enterobacterales/Enterobacteriaceae (CRE) in Indonesia: protocol for systematic review and meta-analysis”

description: This extended data set contains:Appendix 1. Search strategy for PubmedAppendix 2. PRISMA FlowchartPrisma-P checklist<br>
DOI: 10.17632/ky72sb6w6h
title: SAGE-Dataset

description: SAGE-Dataset: Dataset for Knowledge Graph based Recommendation Generation Algorithms
DOI: 10.17632/ykmfygxsr8
title: Corrosion inhibition of steel in seawater through surface phosphate formed from oil

description: To assess the molecule’s effectiveness as an anti-corrosion additive, bis(2-ethylhexyl) phosphate (BEHP) was exposed to carbon steel surfaces from dry and water-saturated dodecane. The resulting changes to the surfaces were characterised using energy dispersive X-ray spectroscopy (EDX), X-ray photoelectron spectroscopy (XPS), polarised neutron reflectometry (PNR), and far-infrared reflection absorption infrared spectroscopy (far-IR RAIRS). We conclude that, although the BEHP molecules showed no observable affinity to the steel surface in dry solvent, a layer of rough iron (III) phosphate formed in water-saturated dodecane. The phosphate-reacted steel surface was resistant to corrosion by seawater, suggesting the formation of a cohesive barrier against corrosive species. The results support the use of BEHP as an anti-corrosion additive and suggest it is a viable phosphating agent for steel surfaces.
DOI: 10.6084/m9.figshare.7570250.v1
title: Additional file 8: of Joint QTL mapping and transcriptome sequencing analysis reveal candidate flowering time genes in Brassica napus L

description: Table S8. Expression analysis of genes of QTL regions in the four samples using RNA-Seq data. EL: leaves of early-flowering bulks; LL: leaves of early-flowering bulks; ES: shoots of late-flowering bulks; LS: shoots of late-flowering bulks. (XLSX 242 kb)
DOI: 10.6084/m9.figshare.1044120.v1
title: HIV and syphilis antenatal screening data at SMRU 2012-13

description: The file is a SAV type file with all variables used in the analysis available in the dataset (syp_hivF1000.sav)
DOI: 10.6084/m9.figshare.5121307.v1
title: Supplementary Material for: Microarray Analysis of Irradiated Growth Plate Zones following Laser Microdissection Shows Later Importance of Differentially Expressed Genes during Radiorecovery

description: <i>Purpose:</i> Potential targets for selective radiorecovery modulation were investigated via the identification of late upregulated genes and pathways during growth plate chondrocyte recovery. <i>Methods and Materials:</i> Three groups of six 5-week-old male Sprague-Dawley rats underwent fractionated irradiation to the right tibiae over 5 days totaling 17.5 Gy and were then killed at 7, 11, and 16 days following the first radiotherapy fraction. The growth plates were collected from the proximal tibiae bilaterally and subsequently underwent laser microdissection to separate reserve, perichondral, proliferative, and hypertrophic zones. Differential gene expression was analyzed between irradiated right and nonirradiated left tibiae using RAE230 2.0 GeneChip microarray, compared between zones and time points, and subjected to functional pathway cluster analysis with real-time polymerase chain reaction (PCR) to confirm selected results. <i>Results:</i> The reserve zone showed the greatest number of differentially expressed genes and enriched pathways: 259 and 134, respectively. Differentially expressed genes included: Timp3, Gpx1, Gas6, Notch2, VEGF, and HIF-1. Enriched pathways included the developmental processes of regeneration, antiapoptosis, developmental growth, tissue regeneration, mesenchymal cell proliferation, negative regulation of immune response, and determination of symmetry. The reserve zone late upregulation of genes was validated using real-time PCR for Mgp, Gas6, and Eef1a1. <i>Conclusions:</i> A significant difference in late upregulated genes between growth plate zones exists. The reserve zone shows the greatest change, containing a 10-fold increase in the total number of genes differentially expressed between days 7 and 16. These findings suggest that reserve zone chondrocytes may play a later role in growth plate recovery response following irradiation.
DOI: 10.6084/m9.figshare.28261658.v1
title: Data from: [Long-term ammonium nitrate addition strengthens soil microbial cross-trophic interactions in a Tibetan alpine steppe]

description: Global nitrogen (N) enrichment is modifying microbial interactions, which can be represented bynetwork complexity. While a number of studies have explored how N addition influences microbial intra-trophic network, its effects on inter-trophic network have rarely been investigated. Here, we examined the effects of 8 years of multi-level N additions(i.e., 0, 1, 2, 4, 8, 16, 24 and 32 g N m-2 year-1) on inter-trophic interactions of soil microbial communities (i.e., protist-fungi, protist-prokaryote and fungi-prokaryote) in a Tibetan alpine steppe. Generally, there was a first increasing and then saturated trend of the complexity of inter-trophic networks along the N-addition gradient, which contrast with the simplified or minimal response of intra-trophic network complexity reported previously. The intensified cross-trophic interactions were mainly explained by increased plant and litter biomass, which indicates that the N-induced increases in carbon supplies may have alleviated microbial energy limitation and thus resulted in more active metabolic processes, consequently stimulating various biotic interactions (e.g., predation, competition and commensalism). Further, the enhanced inter-trophic network relationships were found to associate with increased soil carbon and N mineralization processes. These findings highlight the importance of microbial cross-trophic interactions and indicate that they should be considered in predictions of ecosystem functioning under global N enrichment.
DOI: 10.17632/htm8v59x68
title: Data for: MILP models to minimise makespan in additive manufacturing machine scheduling problems