cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.5281/zenodo.7612312
title: Dataset related to the article "Impact of Prior Statin Therapy on In-Hospital Outcome of STEMI Patients Treated with Primary Percutaneous Coronary Intervention"

description: This record contains raw data related to the article "Impact of Prior Statin Therapy on In-Hospital Outcome of STEMI Patients Treated with Primary Percutaneous Coronary Intervention" <strong>Background</strong>: Prior statin therapy has a cardioprotective effect in patients undergoing elective or urgent percutaneous coronary intervention (PCI). However, data on patients with ST-elevation myocardial infarction (STEMI) undergoing primary PCI are still controversial. We retrospectively evaluated the effect of prior statin therapy on in-hospital clinical outcomes in consecutive STEMI patients undergoing primary PCI. <strong>Methods:</strong> A total of 1790 patients (mean age 67 ± 11 years, 1354 men) were included. At admission, all patients were interrogated about prior (&gt;6 months) statin therapy. The primary endpoint of the study was the composite of in-hospital mortality, acute pulmonary edema, and cardiogenic shock in patients with or without prior statin therapy. <strong>Results:</strong> A total of 427 patients (24%) were on prior statin therapy. The incidence of the primary endpoint was similar in patients with or without prior statin therapy (15% vs. 16%; <em>p</em> = 0.38). However, at multivariate analysis, prior statin therapy was associated with a lower risk of the primary endpoint, after adjustment for major prognostic predictors (odds ratio 0.61 [95% CI 0.39-0.96]; <em>p</em> = 0.03). <strong>Conclusions:</strong> This study demonstrated that prior statin therapy is associated with a better in-hospital clinical outcome in patients with STEMI undergoing primary PCI compared to those without prior statin therapy.
DOI: 10.5281/zenodo.7612311
title: Dataset related to the article "Impact of Prior Statin Therapy on In-Hospital Outcome of STEMI Patients Treated with Primary Percutaneous Coronary Intervention"

description: This record contains raw data related to the article "Impact of Prior Statin Therapy on In-Hospital Outcome of STEMI Patients Treated with Primary Percutaneous Coronary Intervention" <strong>Background</strong>: Prior statin therapy has a cardioprotective effect in patients undergoing elective or urgent percutaneous coronary intervention (PCI). However, data on patients with ST-elevation myocardial infarction (STEMI) undergoing primary PCI are still controversial. We retrospectively evaluated the effect of prior statin therapy on in-hospital clinical outcomes in consecutive STEMI patients undergoing primary PCI. <strong>Methods:</strong> A total of 1790 patients (mean age 67 ± 11 years, 1354 men) were included. At admission, all patients were interrogated about prior (&gt;6 months) statin therapy. The primary endpoint of the study was the composite of in-hospital mortality, acute pulmonary edema, and cardiogenic shock in patients with or without prior statin therapy. <strong>Results:</strong> A total of 427 patients (24%) were on prior statin therapy. The incidence of the primary endpoint was similar in patients with or without prior statin therapy (15% vs. 16%; <em>p</em> = 0.38). However, at multivariate analysis, prior statin therapy was associated with a lower risk of the primary endpoint, after adjustment for major prognostic predictors (odds ratio 0.61 [95% CI 0.39-0.96]; <em>p</em> = 0.03). <strong>Conclusions:</strong> This study demonstrated that prior statin therapy is associated with a better in-hospital clinical outcome in patients with STEMI undergoing primary PCI compared to those without prior statin therapy.
DOI: 10.5281/zenodo.7612371
title: Dataset related to article "Multidisciplinary Tumor Board in the Management of Patients with Colorectal Liver Metastases: A Single-Center Review of 847 Patients "

description: This record contains raw data related to article “Multidisciplinary Tumor Board in the Management of Patients with Colorectal Liver Metastases: A Single-Center Review of 847 Patients" Abstract There is still debate over how reviewing oncological histories and addressing appropriate therapies in multidisciplinary team (MDT) discussions may affect patients' overall survival (OS). The aim of this study was to describe MDT outcomes for a single cancer center's patients affected by colorectal liver metastases (CRLMs). From 2010 to 2020, a total of 847 patients with CRLMs were discussed at our weekly MDT meeting. Patients' characteristics and MDT decisions were analyzed in two groups: patients receiving systemic therapy (ST) versus patients receiving locoregional treatment (LRT). Propensity-score matching (PSM) was run to reduce the risk of selection bias. The median time from MDT indication to treatment was 27 (IQR 13-51) days. The median OS was 30 (95%CI = 27-34) months. After PSM, OS for patients undergoing LRT was 51 (95%CI = 36-64) months compared with 15 (95%CI = 13-20) months for ST patients (<em>p</em> &lt; 0.0001). In this large retrospective study, the MDT discussions were useful in providing the patients with all available locoregional options.
DOI: 10.5281/zenodo.7612370
title: Dataset related to article "Multidisciplinary Tumor Board in the Management of Patients with Colorectal Liver Metastases: A Single-Center Review of 847 Patients "

description: This record contains raw data related to article “Multidisciplinary Tumor Board in the Management of Patients with Colorectal Liver Metastases: A Single-Center Review of 847 Patients" Abstract There is still debate over how reviewing oncological histories and addressing appropriate therapies in multidisciplinary team (MDT) discussions may affect patients' overall survival (OS). The aim of this study was to describe MDT outcomes for a single cancer center's patients affected by colorectal liver metastases (CRLMs). From 2010 to 2020, a total of 847 patients with CRLMs were discussed at our weekly MDT meeting. Patients' characteristics and MDT decisions were analyzed in two groups: patients receiving systemic therapy (ST) versus patients receiving locoregional treatment (LRT). Propensity-score matching (PSM) was run to reduce the risk of selection bias. The median time from MDT indication to treatment was 27 (IQR 13-51) days. The median OS was 30 (95%CI = 27-34) months. After PSM, OS for patients undergoing LRT was 51 (95%CI = 36-64) months compared with 15 (95%CI = 13-20) months for ST patients (<em>p</em> &lt; 0.0001). In this large retrospective study, the MDT discussions were useful in providing the patients with all available locoregional options.
DOI: 10.6084/m9.figshare.22016132
title: TRKB interaction with PSD95 is associated with latency of fluoxetine and 2R,6R-hydroxynorketamine

description: Dataset of the manuscript
DOI: 10.6084/m9.figshare.22016132.v1
title: TRKB interaction with PSD95 is associated with latency of fluoxetine and 2R,6R-hydroxynorketamine

description: Dataset of the manuscript
DOI: 10.25387/g3.21737312
title: Supplemental Material for Kumar et al., 2022

description: Supplemental Figures: Figure S1, Figure S2, Figure S3, Figure S4, and Figure S1, Supplemental_Data_Tables: Table S1, Table S2, phenotypes, genotypes and gene information <br>
DOI: 10.25387/g3.21737312.v1
title: Supplemental Material for Kumar et al., 2022

description: Supplemental Figures: Figure S1, Figure S2, Figure S3, Figure S4, and Figure S1, Supplemental_Data_Tables: Table S1, Table S2, phenotypes, genotypes and gene information <br>
DOI: 10.5281/zenodo.7608255
title: Non-targeted metabolome profiling in splenic monocyte-derived dendritic cells from Plasmodium chabaudi-infecetd mice

description: Spleens from mice infected with Plasmodium chabaudi were processed and stained for localization of monocyte-derived dendritic cells (MODCs) by flow cytometry. The markers utilized were: Live/Dead, F4/80, CD11b, DCSign, MHCII, CD11c and CD3. After sorted out, MODCs were frozen in liquid nitrogen, followed by metabolite extraction, as recommended by The Metabolomics Facility at MD Anderson. Metabolites were extracted using ice-cold 0.1% Ammonium hydroxide in 80/20 (v/v) methanol/water. Extracts were centrifuged at 17,000 g for 5 min at 4°C, and supernatants were transferred to clean tubes, followed by evaporation to dryness under nitrogen. Dried extracts were reconstituted in deionized water, and 5 μL was injected for analysis by ion chromatography (IC)-MS. IC mobile phase A (MPA; weak) was water, and mobile phase B (MPB; strong) was water containing 100 mM KOH. A Thermo Scientific Dionex ICS-5000+ system included a Thermo IonPac AS11 column (4 µm particle size, 250 x 2 mm) with column compartment kept at 30°C. The autosampler tray was chilled to 4°C. The mobile phase flow rate was 350 µL/min and gradient from 1mM to 100mM KOH was used. The total run time was 60 min. To assist the desolvation for better sensitivity, methanol was delivered by an external pump and combined with the eluent via a low dead volume mixing tee. Data were acquired using a Thermo Orbitrap Fusion Tribrid Mass Spectrometer under ESI negative ionization mode at a resolution of 240,000.
DOI: 10.5281/zenodo.7608254
title: Non-targeted metabolome profiling in splenic monocyte-derived dendritic cells from Plasmodium chabaudi-infecetd mice

description: Spleens from mice infected with Plasmodium chabaudi were processed and stained for localization of monocyte-derived dendritic cells (MODCs) by flow cytometry. The markers utilized were: Live/Dead, F4/80, CD11b, DCSign, MHCII, CD11c and CD3. After sorted out, MODCs were frozen in liquid nitrogen, followed by metabolite extraction, as recommended by The Metabolomics Facility at MD Anderson. Metabolites were extracted using ice-cold 0.1% Ammonium hydroxide in 80/20 (v/v) methanol/water. Extracts were centrifuged at 17,000 g for 5 min at 4°C, and supernatants were transferred to clean tubes, followed by evaporation to dryness under nitrogen. Dried extracts were reconstituted in deionized water, and 5 μL was injected for analysis by ion chromatography (IC)-MS. IC mobile phase A (MPA; weak) was water, and mobile phase B (MPB; strong) was water containing 100 mM KOH. A Thermo Scientific Dionex ICS-5000+ system included a Thermo IonPac AS11 column (4 µm particle size, 250 x 2 mm) with column compartment kept at 30°C. The autosampler tray was chilled to 4°C. The mobile phase flow rate was 350 µL/min and gradient from 1mM to 100mM KOH was used. The total run time was 60 min. To assist the desolvation for better sensitivity, methanol was delivered by an external pump and combined with the eluent via a low dead volume mixing tee. Data were acquired using a Thermo Orbitrap Fusion Tribrid Mass Spectrometer under ESI negative ionization mode at a resolution of 240,000.
DOI: 10.6084/m9.figshare.22016009
title: Biotyper evaluation

description: Additional data for the University of Oxford/UKHSA evaluation of the IR-Biotyper.
DOI: 10.6084/m9.figshare.22016009.v1
title: Biotyper evaluation

description: Additional data for the University of Oxford/UKHSA evaluation of the IR-Biotyper.
DOI: 10.6084/m9.figshare.22016147
title: A Two-Sample Conditional Distribution Test Using Conformal Prediction and Weighted Rank Sum

description: We consider the problem of testing the equality of conditional distributions of a response variable given a vector of covariates between two populations. Such a hypothesis testing problem can be motivated from various machine learning and statistical inference scenarios, including transfer learning and causal predictive inference. We develop a nonparametric test procedure inspired from the conformal prediction framework. The construction of our test statistic combines recent developments in conformal prediction with a novel choice of conformity score, resulting in a weighted rank-sum test statistic that is valid and powerful under general settings. To our knowledge, this is the first successful attempt of using conformal prediction for testing statistical hypotheses beyond exchangeability. Our method is suitable for modern machine learning scenarios where the data has high dimensionality and large sample sizes, and can be effectively combined with existing classification algorithms to find good conformity score functions. The performance of the proposed method is demonstrated in various numerical examples.
DOI: 10.6084/m9.figshare.22016147.v1
title: A Two-Sample Conditional Distribution Test Using Conformal Prediction and Weighted Rank Sum

description: We consider the problem of testing the equality of conditional distributions of a response variable given a vector of covariates between two populations. Such a hypothesis testing problem can be motivated from various machine learning and statistical inference scenarios, including transfer learning and causal predictive inference. We develop a nonparametric test procedure inspired from the conformal prediction framework. The construction of our test statistic combines recent developments in conformal prediction with a novel choice of conformity score, resulting in a weighted rank-sum test statistic that is valid and powerful under general settings. To our knowledge, this is the first successful attempt of using conformal prediction for testing statistical hypotheses beyond exchangeability. Our method is suitable for modern machine learning scenarios where the data has high dimensionality and large sample sizes, and can be effectively combined with existing classification algorithms to find good conformity score functions. The performance of the proposed method is demonstrated in various numerical examples.
DOI: 10.5066/p9zgei67
title: Compiled data for groundwater levels, groundwater withdrawals by wells and quarries, and point-source discharges to streams in the vicinity of Willow Grove and Warminster, Bucks and Montgomery Counties, Pennsylvania, for selected years during 1999-2017

description: This USGS Data Release includes hydrologic data compiled for selected years during the period 1990-2017 to support the development and calibration of a numerical groundwater model used to simulate groundwater flow paths at and near former and currently active military bases in Montgomery and Bucks Counties in southeastern Pennsylvania (Goode and Senior, 2020). The hydrologic data compiled for the study area include: 1) withdrawal (pumping) rates for production and other wells; 2) quarry pumping rates; 3) rates of flow discharged to streams from the National Pollution Discharge Elimination System (NPDES) sources, and 4) measured water levels in wells. The data were compiled from various sources described in the metadata for each type of data, with complete references for data sources listed in (Goode and Senior, 2020). Withdrawal (pumping) and discharge rates in the data release represent annual average rates computed as needed from data compiled from various sources. The principal time periods for compiled data include 1990's, 2010, 2013, 2016, and 2017. Some values are estimated where data were missing or not available.
DOI: 10.6073/pasta/f7c0a43cd1ec918e7c48b87fd4071eff
title: Biomass in wet sedge tundra near the Atigun River crossing of the Dalton Highway, North Slope AK, 1982.

description: Biomass in wet sedge tundra near the Atigun River crossing of the Dalton Highway, North Slope AK. There were three harvests; Late May-early June; Late July-early August; Late August-early September. See Shaver and Chapin (Ecological Monographs, 61, 1991 pp.1-31).
DOI: 10.25446/oxford.21632654
title: Round 1 - Test scores

description: The folder contains datasets of the test scores on Math and Literature of primary school grade 2 and lower secondary school grade 7 students in Vietnam in 2017.
DOI: 10.6084/m9.figshare.22015910
title: AOTF SPR spectroscopy experimental data

description: The obtained experimental data is a set of images from the camera (.png) and their corresponding numpy image data (.npy) arrays and spectrum data (.dat) files, and angular scale calibration points (.jpg). The object of the study was a thin film of silver (Ag) with a thickness of 55 nm. At first, a set of silver-coated prisms was made, and in a second step, each prism in a separate process was coated with a thin layer of silicon dioxide with corresponding thicknesses: 13 nm, 17 nm, and 30 nm. Using the PC, we sequentially tune the AOTF starting at a wavelength of approximately 480 nm ending at approximately 780 nm. The camera shoots at 5 exposures (1/1000=0.1 ms, 1/2000=0.5 ms, 1/500=2 ms, 1/200=5 ms, 1/50=20 ms) to achieve a high dynamic range. Data processing source code published at https://github.com/KhasanovISh/Public Materials 2023
DOI: 10.6084/m9.figshare.22015910.v2
title: AOTF SPR spectroscopy experimental data

description: The obtained experimental data is a set of images from the camera (.png) and their corresponding numpy image data (.npy) arrays and spectrum data (.dat) files, and angular scale calibration points (.jpg). The object of the study was a thin film of silver (Ag) with a thickness of 55 nm. At first, a set of silver-coated prisms was made, and in a second step, each prism in a separate process was coated with a thin layer of silicon dioxide with corresponding thicknesses: 13 nm, 17 nm, and 30 nm. Using the PC, we sequentially tune the AOTF starting at a wavelength of approximately 480 nm ending at approximately 780 nm. The camera shoots at 5 exposures (1/1000=0.1 ms, 1/2000=0.5 ms, 1/500=2 ms, 1/200=5 ms, 1/50=20 ms) to achieve a high dynamic range. Data processing source code published at https://github.com/KhasanovISh/Public Materials 2023
DOI: 10.6084/m9.figshare.22015910.v1
title: AOTF SPR spectrosopy experimental data

description: The obtained experimental data is a set of images from the camera (.png) and their corresponding numpy image data (.npy) arrays and spectrum data (.dat) files, and angular scale calibration points (.jpg). The object of the study was a thin film of silver (Ag) with a thickness of 55 nm. At first, a set of silver-coated prisms was made, and in a second step, each prism in a separate process was coated with a thin layer of silicon dioxide with corresponding thicknesses: 13 nm, 17 nm, and 30 nm. Using the PC, we sequentially tune the AOTF starting at a wavelength of approximately 480 nm ending at approximately 780 nm. The camera shoots at 5 exposures (1/1000=0.1 ms, 1/2000=0.5 ms, 1/500=2 ms, 1/200=5 ms, 1/50=20 ms) to achieve a high dynamic range. Data processing source code published at https://github.com/KhasanovISh/Public
DOI: 10.5281/zenodo.7612435
title: Raw data: Role of cardiopulmonary exercise test in the prediction of hemodynamic impairment in patients with pulmonary arterial hypertension

description: Periodic repetition of right heart catheterization (RHC) in pulmonary arterial hypertension (PAH) can be challenging. We evaluated the correlation between RHC and cardiopulmonary exercise test (CPET) aiming at CPET use as a potential noninvasive tool for hemodynamic burden evaluation. One hundred and forty‐four retrospective PAH patients who had performed CPET and RHC within 2 months were enrolled. The following analyses were performed: (a) CPET parameters in hemodynamic variables tertiles; (b) position of hemodynamic parameters in the peak end‐tidal carbon dioxide pressure (P<sub>ET</sub>CO<sub>2</sub>) versus ventilation/carbon dioxide output (VE/VCO<sub>2</sub>) slope scatterplot, which is a specific hallmark of exercise respiratory abnormalities in PAH; (c) association between CPET and a hemodynamic burden score developed including mean pulmonary arterial pressure (mPAP), pulmonary vascular resistance (PVR), cardiac index, and right atrial pressure. VE/VCO<sub>2</sub> slope and peak P<sub>ET</sub>CO<sub>2</sub> significantly varied in mPAP and PVR tertiles, while peak oxygen uptake (peak VO<sub>2</sub>) and O<sub>2</sub> pulse varied in the tertiles of all hemodynamic parameters. P<sub>ET</sub>CO<sub>2</sub> versus VE/VCO<sub>2</sub> slope showed a strong hyperbolic relationship (<em>R</em> <sup>2</sup> =&thinsp;0.7627). Patients with peak P<sub>ET</sub>CO<sub>2</sub> &gt; median (26 mmHg) and VE/VCO<sub>2</sub> slope &lt; median (44) presented lower mPAP and PVR (p &lt; 0.005) than patients with peak P<sub>ET</sub>CO<sub>2</sub> &lt; median and VE/VCO<sub>2</sub> slope &gt; median. Multivariate analysis individuated peak VO<sub>2</sub> (<em>p</em> =&thinsp;0.0158) and peak P<sub>ET</sub>CO<sub>2</sub> (<em>p</em> =&thinsp;0.0089) as hemodynamic score independent predictors; the formula 11.584 − 0.0925 × peak VO<sub>2</sub> − 0.0811 × peak P<sub>ET</sub>CO<sub>2</sub> best predicts the hemodynamic score value from CPET data. A significant correlation was found between estimated and calculated scores (<em>p</em> &lt; 0.0001), with a precise match for patients with mild‐to‐moderate hemodynamic burden (76% of cases). The results of the present study suggest that CPET could allow to estimate the hemodynamic burden in PAH patients.
DOI: 10.5281/zenodo.7612434
title: Raw data: Role of cardiopulmonary exercise test in the prediction of hemodynamic impairment in patients with pulmonary arterial hypertension

description: Periodic repetition of right heart catheterization (RHC) in pulmonary arterial hypertension (PAH) can be challenging. We evaluated the correlation between RHC and cardiopulmonary exercise test (CPET) aiming at CPET use as a potential noninvasive tool for hemodynamic burden evaluation. One hundred and forty‐four retrospective PAH patients who had performed CPET and RHC within 2 months were enrolled. The following analyses were performed: (a) CPET parameters in hemodynamic variables tertiles; (b) position of hemodynamic parameters in the peak end‐tidal carbon dioxide pressure (P<sub>ET</sub>CO<sub>2</sub>) versus ventilation/carbon dioxide output (VE/VCO<sub>2</sub>) slope scatterplot, which is a specific hallmark of exercise respiratory abnormalities in PAH; (c) association between CPET and a hemodynamic burden score developed including mean pulmonary arterial pressure (mPAP), pulmonary vascular resistance (PVR), cardiac index, and right atrial pressure. VE/VCO<sub>2</sub> slope and peak P<sub>ET</sub>CO<sub>2</sub> significantly varied in mPAP and PVR tertiles, while peak oxygen uptake (peak VO<sub>2</sub>) and O<sub>2</sub> pulse varied in the tertiles of all hemodynamic parameters. P<sub>ET</sub>CO<sub>2</sub> versus VE/VCO<sub>2</sub> slope showed a strong hyperbolic relationship (<em>R</em> <sup>2</sup> =&thinsp;0.7627). Patients with peak P<sub>ET</sub>CO<sub>2</sub> &gt; median (26 mmHg) and VE/VCO<sub>2</sub> slope &lt; median (44) presented lower mPAP and PVR (p &lt; 0.005) than patients with peak P<sub>ET</sub>CO<sub>2</sub> &lt; median and VE/VCO<sub>2</sub> slope &gt; median. Multivariate analysis individuated peak VO<sub>2</sub> (<em>p</em> =&thinsp;0.0158) and peak P<sub>ET</sub>CO<sub>2</sub> (<em>p</em> =&thinsp;0.0089) as hemodynamic score independent predictors; the formula 11.584 − 0.0925 × peak VO<sub>2</sub> − 0.0811 × peak P<sub>ET</sub>CO<sub>2</sub> best predicts the hemodynamic score value from CPET data. A significant correlation was found between estimated and calculated scores (<em>p</em> &lt; 0.0001), with a precise match for patients with mild‐to‐moderate hemodynamic burden (76% of cases). The results of the present study suggest that CPET could allow to estimate the hemodynamic burden in PAH patients.
DOI: 10.5281/zenodo.7612471
title: Fast Initiating Furan-Containing Hoveyda-Type Complexes: Synthesis and Applications in Metathesis Reactions

description: Data confirming the structure of the new compounds obtained within the project, published in <em>Chemistry</em> <strong>2022</strong>, <em>4</em>(3), 786-795; https://doi.org/10.3390/chemistry4030056 The research was performed within SONATA BIS project and was funded by National Science Centre, Poland, grant number DEC-2021/42/E/ST4/00187.