cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.5057464.v1
title: Supplementary Material for: High-Dose Cannabidiol-Induced Hypotension after Global Hypoxia-Ischemia in Piglets

description: <b><i>Background:</i></b> Cannabidiol (CBD) is considered a promising neuroprotectant after perinatal hypoxia-ischemia (HI). We have previously studied the effects of CBD 1 mg/kg in the early phase after global HI in piglets. In contrast to prior studies, we found no evidence of neuroprotection and hypothesized that higher doses might be required to demonstrate efficacy in this animal model. <b><i>Objective:</i></b> To assess the safety and potential neuroprotective effects of high-dose CBD. <b><i>Methods:</i></b> Anesthetized newborn piglets underwent global HI by ventilation with 8% O<sub>2</sub> until the point of severe metabolic acidosis (base excess -20 mmol/L) and/or hypotension (mean arterial blood pressure ≤20 mm Hg). Piglets were randomized to intravenous treatment with vehicle (<i>n</i> = 9) or CBD (<i>n</i> = 13). The starting dose, CBD 50 mg/kg, was reduced if adverse effects occurred. The piglets were euthanized 9.5 h after HI and tissue was collected for analysis. <b><i>Results:</i></b> CBD 50 mg/kg (<i>n</i> = 4) induced significant hypotension in 2 out of 4 piglets, and 1 out of 4 piglets suffered a fatal cardiac arrest. CBD 25 mg/kg (<i>n</i> = 4) induced significant hypotension in 1 out of 4 piglets, while 10 mg/kg (<i>n</i> = 5) was well tolerated. A significant negative correlation between the plasma concentration of CBD and hypotension during drug infusion was observed (<i>p</i> &lt; 0.005). Neuroprotective effects were evaluated in piglets that did not display significant hypotension (<i>n</i> = 9) and CBD did not alter the degree of neuronal damage as measured by a neuropathology score, levels of the astrocytic marker S100B in CSF, magnetic resonance spectroscopy markers (Lac/NAA and Glu/NAA ratios), or plasma troponin T. <b><i>Conclusions:</i></b> High-dose CBD can induce severe hypotension and did not offer neuroprotection in the early phase after global HI in piglets.
DOI: 10.6084/m9.figshare.5057131
title: Efficacy and safety of glucocorticoids combined with hyperbaric oxygen therapy in the treatment of delayed encephalopathy after acute carbon monoxide poisoning: study protocol for a randomized controlled trial

description: Background: About half of patients with acute carbon monoxide (CO) poisoning suffer from delayed post-anoxic encephalopathy. Days or weeks after apparent recovery from acute CO poisoning, patients present with sudden onset neurophysiological symptoms, mainly symptoms of dementia, with a high risk of permanent disability or death. Glucocorticoids not only regulate the biosynthesis and metabolismof blood glucose, fat, and protein, but also inhibit the immune response and exhibit anti-inflammatory, anti-toxic, and anti-shock effects. Glucocorticoids can improve the clinical symptoms of delayed encephalopathy; however, the therapeutic effects of glucocorticoidscombined with hyperbaric oxygen therapy (HBOT) on delayed encephalopathy after acute CO poisoning are poorly understood.Methods/Design: This is a single-center, prospective, single-blind, randomized controlled trial, which will be performed at Baotou Center Hospital, China. A total of 120 eligible patients with delayed encephalopathy after acute CO poisoning will be randomly assignedto receive either basic treatment + HBOT + intravenous dexamethasone (trial group, n = 60) or basic treatment + HBOT (control group, n = 60). Intravenous injection of dexamethasone (10 mg, once a day, for 14 successive days) will be performed. HBOT (once a day, for 14 successive days) will be administered through a multi-place hyperbaric chamber that will be pressurized with 100% O2 to 2–2.2 atmospheres absolute within 25 minutes, followed by 60 minutes of pressure stabilization, 10 minutes of resting, and 25 minutes of depressurization. The primary and secondary outcome measures of this study will be evaluated at baseline, 7, 14, 30, 60 and 90 days after treatment. The primary outcome measure is the Barthel Index of Activities of Daily Living change. The secondary outcome measures are Mini-Mental State Examination score, modified Ashworth Scale score and European Quality of Life-5 Dimensionsquestionnaire score, as well as adverse reactions and death rate.Discussion: This study will be conducted to analyze the clinical therapeutic efficacy and safety of glucocorticoids combined with hyperbaric oxygen therapy in the treatment of delayed encephalopathy after acute CO poisoning.Trial registration: This study protocol was registered with Chinese Clinical Trial Registry (registration number: ChiCTR-IPR-16009743) on 5 November 2016.doi: 10.4103/2542-3932.198961How to cite this article: Xiang WP, Xue H, Wang BJ (2017) Efficacy and safety of glucocorticoids combined with hyperbaric oxygen therapy in the treatment of delayed encephalopathy after acute carbon monoxide poisoning: study protocol for a randomized controlled trial. Asia Pac J Clin Trials Nerv Syst Dis 2(1):15-22.
DOI: 10.6084/m9.figshare.5057143
title: Supplementary Material for: High-Flux Dialysis: Clinical, Biochemical, and Proteomic Comparison with Low-Flux Dialysis and On-Line Hemodiafiltration

description: Hemodiafiltration on-line (on-line HDF) is a more efficient treatment than low-flux hemodialysis (HD). Unfortunately, it cannot be proposed to all patients. The aim of this study was to evaluate the safety, efficiency, and mechanisms of removal of toxins with high-flux HD vs. low-flux HD and on-line HDF. Randomized cross-over study designed to evaluate efficiency and tolerability of high-flux HD vs. low-flux HD in aged patients; to compare by means of biochemical and proteomic analyses the efficiency and mechanisms of removal of toxins with high-flux HD vs. on-line HDF. The removal of small toxins was similar with high-flux and low-flux HD. β2-microglobulin was removed only with high-flux HD, which had an excellent tolerability. The efficiency of high-flux HD was similar to on-line HDF. Proteomic analysis demonstrated that only high-flux membranes remove and adsorb small proteins. High-flux HD may be an efficient alternative to on-line HDF.
DOI: 10.6084/m9.figshare.5057131.v1
title: Efficacy and safety of glucocorticoids combined with hyperbaric oxygen therapy in the treatment of delayed encephalopathy after acute carbon monoxide poisoning: study protocol for a randomized controlled trial

description: Background: About half of patients with acute carbon monoxide (CO) poisoning suffer from delayed post-anoxic encephalopathy. Days or weeks after apparent recovery from acute CO poisoning, patients present with sudden onset neurophysiological symptoms, mainly symptoms of dementia, with a high risk of permanent disability or death. Glucocorticoids not only regulate the biosynthesis and metabolismof blood glucose, fat, and protein, but also inhibit the immune response and exhibit anti-inflammatory, anti-toxic, and anti-shock effects. Glucocorticoids can improve the clinical symptoms of delayed encephalopathy; however, the therapeutic effects of glucocorticoidscombined with hyperbaric oxygen therapy (HBOT) on delayed encephalopathy after acute CO poisoning are poorly understood.Methods/Design: This is a single-center, prospective, single-blind, randomized controlled trial, which will be performed at Baotou Center Hospital, China. A total of 120 eligible patients with delayed encephalopathy after acute CO poisoning will be randomly assignedto receive either basic treatment + HBOT + intravenous dexamethasone (trial group, n = 60) or basic treatment + HBOT (control group, n = 60). Intravenous injection of dexamethasone (10 mg, once a day, for 14 successive days) will be performed. HBOT (once a day, for 14 successive days) will be administered through a multi-place hyperbaric chamber that will be pressurized with 100% O2 to 2–2.2 atmospheres absolute within 25 minutes, followed by 60 minutes of pressure stabilization, 10 minutes of resting, and 25 minutes of depressurization. The primary and secondary outcome measures of this study will be evaluated at baseline, 7, 14, 30, 60 and 90 days after treatment. The primary outcome measure is the Barthel Index of Activities of Daily Living change. The secondary outcome measures are Mini-Mental State Examination score, modified Ashworth Scale score and European Quality of Life-5 Dimensionsquestionnaire score, as well as adverse reactions and death rate.Discussion: This study will be conducted to analyze the clinical therapeutic efficacy and safety of glucocorticoids combined with hyperbaric oxygen therapy in the treatment of delayed encephalopathy after acute CO poisoning.Trial registration: This study protocol was registered with Chinese Clinical Trial Registry (registration number: ChiCTR-IPR-16009743) on 5 November 2016.doi: 10.4103/2542-3932.198961How to cite this article: Xiang WP, Xue H, Wang BJ (2017) Efficacy and safety of glucocorticoids combined with hyperbaric oxygen therapy in the treatment of delayed encephalopathy after acute carbon monoxide poisoning: study protocol for a randomized controlled trial. Asia Pac J Clin Trials Nerv Syst Dis 2(1):15-22.
DOI: 10.6084/m9.figshare.5057065
title: Development and validation of a drinking water temperature model in domestic drinking water supply systems

description: Domestic drinking water supply systems (DDWSs) are the final step in the delivery of drinking water to consumers. Temperature is one of the rate-controlling parameters for many chemical and microbiological processes and is, therefore, considered as a surrogate parameter for water quality processes. In this study, a mathematical model is presented that predicts temperature dynamics of the drinking water in DDWSs. A full-scale DDWS resembling a conventional system was built and run according to one year of stochastic demands with a time step of 10 s. The drinking water temperature was measured at each point-of-use in the systems and the data-set was used for model validation. The temperature model adequately reproduced the temperature profiles, both in cold and hot water lines, in the full-scale DDWS. The model showed that inlet water temperature and ambient temperature have a large effect on the water temperature in the DDWSs.
DOI: 10.6084/m9.figshare.5057065.v1
title: Development and validation of a drinking water temperature model in domestic drinking water supply systems

description: Domestic drinking water supply systems (DDWSs) are the final step in the delivery of drinking water to consumers. Temperature is one of the rate-controlling parameters for many chemical and microbiological processes and is, therefore, considered as a surrogate parameter for water quality processes. In this study, a mathematical model is presented that predicts temperature dynamics of the drinking water in DDWSs. A full-scale DDWS resembling a conventional system was built and run according to one year of stochastic demands with a time step of 10 s. The drinking water temperature was measured at each point-of-use in the systems and the data-set was used for model validation. The temperature model adequately reproduced the temperature profiles, both in cold and hot water lines, in the full-scale DDWS. The model showed that inlet water temperature and ambient temperature have a large effect on the water temperature in the DDWSs.
DOI: 10.6084/m9.figshare.5057053
title: Scalp acupuncture for dyskinesia after ischemic stroke: study protocol for a parallel randomized controlled clinical trial

description: Fugl-Meyer Motor AssessmentBackground: Scalp acupuncture formed by combining traditional Chinese acupuncture techniques and modern theories in medical anatomy has been widely used to treat ischemic stroke in China, but effective clinical trials that verify its efficacy are lacking. This study proposes to verify the effects of Lu’s scalp acupuncture on ischemic stroke by comparing differential improvement of motor function between conventional rehabilitation alone and conventional rehabilitation with Lu’s scalp acupuncture.Methods/Design: We will conduct a randomized, controlled, parallel, clinical trial. We will collect 116 ischemic stroke patients with dyskinesia from Longhua Hospital, Shanghai University of Traditional Chinese Medicine and Huashan Hospital, Fudan University in China. All patients will be equally randomized into either a control group (conventional rehabilitation) or an experimental group (scalp acupuncture + conventional rehabilitation). In the control group, patients will receive conventional rehabilitation according to the Guidelines for Stroke Rehabilitation in China. In the experimental group, conventional rehabilitation will be supplemented with oblique acupuncture at approximately 30° and an insertion depth of 25–35 mm in the anterior oblique line of vertex-temporal (MS6). Twisting speed will be 200 times per minute. Acupuncture will be performed 30 minutes, once per day. Patients in both groups will receive rehabilitation five times per week for 8 consecutive weeks. The primary outcome will be the difference in Fugl-Meyer assessmentmotor function score between posttreatment (4 weeks, 8 weeks, and 6 months of follow-up) and baseline. The secondary outcomes will be differences in the Modified Barthel Index, stroke-specific quality of life, and stroke syndrome of traditional Chinese medicine.Discussion: This trial will provide objective data on the effectiveness of scalp acupuncture in ischemic stroke patients with dyskinesia.Trial registration: ClinicalTrials.gov identifier: NCT03120650.
DOI: 10.6084/m9.figshare.5057041
title: Alien plant invasion in European woodlands

description: Depository for R scripts and selected data underlying the publication: <br><br>Wagner, V., Chytrý, M., Jiménez-Alfaro, B., Pergl, J., Hennekens, S., Biurrun, I. Knollová, I., Berg, C., Vassilev, K., Rodwell, J., Škvorc, Ž., Jandt, J., Ewald, J., Jansen, F., Tsiripidis, I., Botta-Dukát, Z., Casella, L., Attorre, F., Rašomavičius, V., Ćušterevska, R., Schaminée, R.H.J, Brunet, J., Lenoir, F., Svenning, J.-C, Kącki, Z., Petrášová-Šibíková, M., Šilc, U., García-Mijangos, I., Campos, J.A., Fernández-González, F., Wohlgemuth, T., Onyshchenko, V., Pyšek, P. (in press) Alien plant invasions across European woodlands. Diversity and Distributions. <br><br> Important notes:<br>(1) R scripts can only be fully executed if all data are supplied. (2) Data files are listed in Overview_data.xlsx. (3) Data include open-access and non-open-access files. The latter encompass mostly files based on the European Vegetation Archive (EVA), which cannot be posted publically due to the EVA bylaws. (4) To obtain the folder with non-open-access data, please contact the following scientists: <br>Viktoria Wagner, wagner@sci.muni.cz Milan Chytrý, chytry@sci.muni.cz Ilona Knollová, ikuzel@sci.muni.cz
DOI: 10.6084/m9.figshare.5057053.v1
title: Scalp acupuncture for dyskinesia after ischemic stroke: study protocol for a parallel randomized controlled clinical trial

description: Fugl-Meyer Motor AssessmentBackground: Scalp acupuncture formed by combining traditional Chinese acupuncture techniques and modern theories in medical anatomy has been widely used to treat ischemic stroke in China, but effective clinical trials that verify its efficacy are lacking. This study proposes to verify the effects of Lu’s scalp acupuncture on ischemic stroke by comparing differential improvement of motor function between conventional rehabilitation alone and conventional rehabilitation with Lu’s scalp acupuncture.Methods/Design: We will conduct a randomized, controlled, parallel, clinical trial. We will collect 116 ischemic stroke patients with dyskinesia from Longhua Hospital, Shanghai University of Traditional Chinese Medicine and Huashan Hospital, Fudan University in China. All patients will be equally randomized into either a control group (conventional rehabilitation) or an experimental group (scalp acupuncture + conventional rehabilitation). In the control group, patients will receive conventional rehabilitation according to the Guidelines for Stroke Rehabilitation in China. In the experimental group, conventional rehabilitation will be supplemented with oblique acupuncture at approximately 30° and an insertion depth of 25–35 mm in the anterior oblique line of vertex-temporal (MS6). Twisting speed will be 200 times per minute. Acupuncture will be performed 30 minutes, once per day. Patients in both groups will receive rehabilitation five times per week for 8 consecutive weeks. The primary outcome will be the difference in Fugl-Meyer assessmentmotor function score between posttreatment (4 weeks, 8 weeks, and 6 months of follow-up) and baseline. The secondary outcomes will be differences in the Modified Barthel Index, stroke-specific quality of life, and stroke syndrome of traditional Chinese medicine.Discussion: This trial will provide objective data on the effectiveness of scalp acupuncture in ischemic stroke patients with dyskinesia.Trial registration: ClinicalTrials.gov identifier: NCT03120650.
DOI: 10.6084/m9.figshare.5057014
title: Species status and origin

description: Data on species status and geographic origin, accompanying the publication <strong>Wagner, V.</strong>, Chytrý, M., Jiménez-Alfaro, B., Pergl, J., Hennekens, S., Biurrun, I., Knollová, I., Berg, C., Vassilev, K., Rodwell, J. S., Škvorc, Ž., Jandt, U., Ewald, J., Jansen, F., Tsiripidis, I., Botta-Dukát, Z., Casella, L., Attorre, F., Rašomavičius, V., Ćušterevska, R., Schaminée, J. H. J., Brunet, J., Lenoir, J., Svenning, J.-C., Kaçki, Z., Petrášová-Šibíková, M., Šilc, U., García-Mijangos, I., Campos, J. A., Fernández-González, F., Wohlgemuth, T., Onyshchenko, V., Pyšek, P. (accepted) Alien plant invasions across European woodlands. <em>Diversity and Distributions</em>.<br><br>Species.name.original = Original species name as specified in EVA. <br>Species.name = Species name after spell-checking and taxonomic standardization. <br>Region = Geographic region as defined in the paper. <br>Status = Species status in the region (see paper for details on methods). <br>Origin = Species geographic origin (extra: outside of Europe, intra: from another region in Europe).<br><br>See also accompanying R-script.<br>
DOI: 10.6084/m9.figshare.5057041.v1
title: Alien plant invasion in European woodlands

description: Depository for R scripts and selected data underlying the publication: <br><br>Wagner, V., Chytrý, M., Jiménez-Alfaro, B., Pergl, J., Hennekens, S., Biurrun, I. Knollová, I., Berg, C., Vassilev, K., Rodwell, J., Škvorc, Ž., Jandt, J., Ewald, J., Jansen, F., Tsiripidis, I., Botta-Dukát, Z., Casella, L., Attorre, F., Rašomavičius, V., Ćušterevska, R., Schaminée, R.H.J, Brunet, J., Lenoir, F., Svenning, J.-C, Kącki, Z., Petrášová-Šibíková, M., Šilc, U., García-Mijangos, I., Campos, J.A., Fernández-González, F., Wohlgemuth, T., Onyshchenko, V., Pyšek, P. (in revision) Alien plant invasions across European woodlands. Diversity and Distributions. <br><br>Please note that the R scripts will not run unless the non-open-source data from the European Vegetation Archive and other selected data sources are supplied. To obtain these data, please contact the European Vegetation Archive.<br>
DOI: 10.6084/m9.figshare.5056906
title: IDENTIFICATION OF VOLATILES RELEASED BY DIAPAUSING BROWN MARMORATED STINK BUGS, Halyomorpha halys (HEMIPTERA: PENTATOMIDAE)

description: Raw data being made available to go alongside the open access paper and thesis chapter of the same name.<br>
DOI: 10.6084/m9.figshare.5056912
title: 否定词集合.xlsx

description: Negative words
DOI: 10.6084/m9.figshare.5056912.v1
title: 否定词集合.xlsx

description: Negative words
DOI: 10.6084/m9.figshare.5056903
title: 实验数据集.xlsx

description: experimental data
DOI: 10.6084/m9.figshare.5056900
title: 基于手机评论的补充情感词典.xlsx

description: Mobile emotion dictionary for experiment
DOI: 10.6084/m9.figshare.5056903.v1
title: 实验数据集.xlsx

description: experimental data
DOI: 10.6084/m9.figshare.5056891
title: 否定词集合.txt

description: Negative words of experiment
DOI: 10.6084/m9.figshare.5056900.v1
title: 基于手机评论的补充情感词典.xlsx

description: Mobile emotion dictionary for experiment
DOI: 10.6084/m9.figshare.5056906.v1
title: IDENTIFICATION OF VOLATILES RELEASED BY DIAPAUSING BROWN MARMORATED STINK BUGS, Halyomorpha halys (HEMIPTERA: PENTATOMIDAE)

description: Raw data being made available to go alongside the open access paper of the same name.<br>
DOI: 10.6084/m9.figshare.5056891.v1
title: N_Words.txt

description: Negative words of experiment
DOI: 10.6084/m9.figshare.5056891.v3
title: 否定词集合.txt

description: Negative words of experiment
DOI: 10.6084/m9.figshare.5056906.v2
title: IDENTIFICATION OF VOLATILES RELEASED BY DIAPAUSING BROWN MARMORATED STINK BUGS, Halyomorpha halys (HEMIPTERA: PENTATOMIDAE)

description: Raw data being made available to go alongside the open access paper and thesis chapter of the same name.<br>
DOI: 10.6084/m9.figshare.5056867
title: landsat-scenes

description: some test data for stack overflow<br>
DOI: 10.6084/m9.figshare.5056906.v3
title: IDENTIFICATION OF VOLATILES RELEASED BY DIAPAUSING BROWN MARMORATED STINK BUGS, Halyomorpha halys (HEMIPTERA: PENTATOMIDAE)

description: Raw data being made available to go alongside the open access paper and thesis chapter of the same name.<br>
DOI: 10.6084/m9.figshare.5056837
title: HIV-1 full-genome phylogenetics of generalized epidemics in sub-Saharan Africa: impact of missing nucleotide characters in next-generation sequences

description: Simulation studies were conducted to characterise the implications of missing nucleotide characters in PANGEA-HIV sequences on tree reconstruction accuracy. An individual-level transmission model was used to generate regional HIV-1 epidemics, as well as corresponding HIV-1 phylogenies and full genome sequences. Each simulated sequence was paired at random with a PANGEA-HIV sequence, and missing nucleotide patterns of PANGEA-HIV sequences were superimposed onto the simulated sequences. This data contains the simulated sequence alignments, and might be useful to benchmark tree reconstruction tools.
DOI: 10.6084/m9.figshare.5056906.v5
title: IDENTIFICATION OF VOLATILES RELEASED BY DIAPAUSING BROWN MARMORATED STINK BUGS, Halyomorpha halys (HEMIPTERA: PENTATOMIDAE)

description: Raw data being made available to go alongside the open access paper and thesis chapter of the same name.<br>
DOI: 10.6084/m9.figshare.5056867.v2
title: landsat-scenes

description: some test data for stack overflow<br>
DOI: 10.6084/m9.figshare.5056906.v4
title: IDENTIFICATION OF VOLATILES RELEASED BY DIAPAUSING BROWN MARMORATED STINK BUGS, Halyomorpha halys (HEMIPTERA: PENTATOMIDAE)

description: Raw data being made available to go alongside the open access paper and thesis chapter of the same name.<br>