cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.17632/hkhvksr37m.1
title: Temporal genomic analysis of homogeneous tumor models reveals key regulators of immune evasion in melanoma

description: Low intra-tumor heterogeneity (ITH) correlates with increased patient survival and immunotherapy response. However, even highly homogeneous tumors are variably aggressive, and the immunological factors impacting aggressiveness remain understudied. Here, we analyzed the mechanisms underlying immune-escape in murine tumors with low ITH. We used immunophenotyping and single-cell RNA sequencing to compare the temporal growth of in-vivo transplanted, genetically similar rejected vs. non-rejected single-cell clones. Non-rejected clones showed high infiltration of tumor-associated macrophages (TAMs), lower T-cell infiltration, and increased T-cell exhaustion compared to rejected clones. Comparative analysis of rejection-associated gene expression programs, combined with in-vivo CRISPR knockout screens of candidate regulators, identified Mif (macrophage migration inhibitory factor) as a major contributor to immune rejection. Mif knockout resulted in smaller tumors and reduced immunosuppressive macrophage infiltration. These results were validated in melanoma patient data. Overall, our homogeneous tumor system can uncover factors regulating growth variability and identifies Mif as critical in aggressive melanoma.

We profiled the tumor microenvironment of mice transplanted with rejected and non-rejected tumor clones at 10 days post tumor inoculation using CyTOF. We also compared Mif KO and control non-rejected clones using CyTOF. Raw CyTOF data were first bead normalized to remove acquisition sensitivity-related influences on marker expression using Fluidigm’s software. Normalized data were uploaded to the Flowjo analysis platform to identify single, live cells by excluding remaining beads (140Ce and 153Eu) and gating on DNA (193Ir) and viability (195Pt) channels. Next, barcoded cells were assigned back to their initial samples using their unique Cd barcode combination using the MatLab single cell debarcoder.
DOI: 10.17632/786zjg6v6z.1
title: Teaching Strategies

description: Researches about Teaching Strategies
DOI: 10.17632/s2yrrx2s3w.1
title: Classroom Management

description: Research About Classroom Management
DOI: 10.15468/dl.t9jbn4
title: Occurrence Download

description: A dataset containing 18174 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Puma concolor (Linnaeus, 1771))",
 "HasCoordinate is true"
 ]
}

 The dataset includes 18174 records from 291 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0011081-241024112534372/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.17632/nnyywk77v9.1
title: Characterization and Classification of Major Agricultural Soils along Topo-sequence of Tuji Gebisa Subwatershed, Eastern Hararghe, Ethiopia

description: This data is a raw data recorded in the laboratory for assisting morphological characteristics identified in the field experiments and used for analyses of soil properties.
DOI: 10.17632/ry24h5f2r2.1
title: NO-FAIL POLICY: IMPACT ON THE ACADEMIC PERFORMANCE OF THE LEARNERS AMIDST THE PANDEMIC

description: The "No-Fail Policy" in educational contexts generally refers to a system where students are not given failing grades, typically to reduce pressure, support mental health, or address disparities. Amidst the COVID-19 pandemic, many schools implemented such policies to account for the unique challenges students faced, like lack of internet access, health concerns, and increased stress from rapid changes in teaching formats. Here's an outline of how this policy might impact learners' academic performance during the pandemic:

Positive Impacts
Reduced Anxiety and Stress: The pandemic caused unprecedented stress for students, with many balancing personal challenges alongside their studies. A no-fail policy provided a safety net that reduced anxiety around academic pressures.

Increased Focus on Learning Over Grading: Without the pressure of failing grades, students could focus more on understanding material rather than merely striving to avoid failure.

Equitable Treatment Across Different Learning Environments: Since not all students had access to the same resources (e.g., stable internet, quiet learning environments), the policy helped level the playing field for those disproportionately impacted by these limitations.

Encouragement to Continue Education: The policy potentially decreased dropout rates by encouraging students to stay engaged even if their grades suffered, which helped maintain continuity in education.

Negative Impacts
Reduced Academic Accountability: Without the risk of failing, some students might not put in the necessary effort, which could reduce overall learning outcomes and mastery of content.

Lowered Standards of Achievement: Some educators and parents worry that no-fail policies set a precedent that de-emphasizes academic excellence and creates a gap in foundational knowledge.

Difficulty in Measuring True Academic Performance: Teachers may find it challenging to gauge students' true academic progress, which could affect preparation for future coursework or career paths that require strong foundational knowledge.

Long-Term Effects on Work Ethic and Motivation: Critics argue that no-fail policies might inadvertently affect students’ work ethic, making it difficult for them to transition back to environments with more traditional grading standards.

Conclusion
The no-fail policy amidst the pandemic was primarily a support measure, ensuring that students continued to learn in difficult circumstances. However, while it addressed immediate inequities and mental health concerns, its long-term impact on academic performance and motivation is complex and still under study, as educational systems now look at how to balance support with accountability moving forward.
DOI: 10.17632/rh5k7dzr9m.1
title: Protective Role of Bre1 in Mitochondrial Function and Energy Metabolism in Drosophila Models of Parkinson’s disease

description: Bre1 is considered to play a crucial role in the clearance of damaged mitochondria, and the impairment of this clearance process is a major contributor to the progression of Parkinson's disease (PD). Therefore, we hypothesize that Bre1 may have a significant role in the development of PD. To test this hypothesis, we generated Drosophila lines with overexpression and knockdown of Bre1 and crossed them with PD model flies. This resulted in PD model flies with either overexpressed or knocked down Bre1.We used RNA-Seq to analyze the gene expression profiles of these flies and found that overexpression of Bre1 led to a significant enrichment of genes related to energy metabolism. Conversely, knockdown of Bre1 increased the expression of many peroxisomal genes. Based on these findings, we propose that Bre1 may improve PD symptoms by enhancing energy supply in PD.
DOI: 10.17632/wwdrfs5byv.1
title: NDRG1–HIF1α Interaction in Hypoxic Signaling for PAH

description: Uncut original gel
DOI: 10.17632/mgbhhmr3dd.1
title: Global Trends in Atopic Dermatitis Burden

description: Supplemental material for "The Global Burden of Atopic Dermatitis in Children and Adolescents, and Projections to 2036: Findings from the Global Burden of Disease Study, 1990-2021"
DOI: 10.17632/srj3zxjfj5.1
title: Evidence for Using Synthetic Bone Grafts for the Treatment of Osteonecrosis of the Femoral Head: A Systematic Review of the Literature and Meta-analysis.

description: Background: Synthetic bone grafts (SBG) potentially add structural stability after core 
decompression (CD) for osteonecrosis of the femoral head (ONFH). This systematic review and 
meta-analysis assessed the evidence supporting the (1) clinical efficacy, (2) radiographic efficacy; 
(3) revision rates, and (4) safety of CD and CD with SBG for the treatment of ONFH. 
Methods: A total of 6,549 papers were screened. Inclusion criteria were met by 25 studies for CD 
and by 16 studies for CD+SBG. This study included 1,929 hips with ONFH – 1,256 treated with 
CD, 499 treated with CD+SBG, and 174 treated with CD+SBG with adjuvant therapies 
(CD+SBG+ADJ). 
Results: The clinically defined failure rate (CF) was 50% for CD, 22% for CD+SBG and 13% for 
CD+SBG+ADJ with significantly lower CF in CD+SBG than in the CD group (p=0.02). The 
radiographic progression (RP) was 47% for CD, 32% for CD+SBG, and 28% for CD+SBG+ADJ 
with no differences between subgroups (p=0.12). The mean total hip arthroplasty (THA) 
conversion rate was 39% for CD, 23% for CD+SBG and 19% for CD+SBG+ADJ with a 
significantly lower THA conversion rate in the CD+SBG (p&lt;0.01) and CD+SBG+ADJ (p=0.02) 
groups than in the CD group. The complication rates were 7.4% for CD and 2.2% for CD+SBG 
and CD+SBG+ADJ groups combined. When comparing studies from the same period (after year 
2000), there were no significant differences between the three groups in THA conversion rate 
(p=0.14), RP (p=0.58), and CF (p=0.35).
Conclusion: There is no clear evidence that adding synthetic bone grafts to a core decompression 
produces better results than core decompression alone when comparing studies from the same 
period.
DOI: 10.17632/5x54wp7jm7.1
title: Original datasets for Adipocyte-derived ferroptotic signaling mitigates obesity

description: Oxylipins datasets
DOI: 10.17632/7fh2957bkz.2
title: Evaluating the Adequacy of Public Open Space for the Residents of Subdivisions in Cabanatuan City Central Business District

description: Public Open Spaces (POS) and Urban Green Spaces (UGS) are vital elements of the urban milieu, providing recreational opportunities and enhancing residents’ quality of life. However, in some localities in the Philippines such as the City of Cabanatuan particularly in its inner-city was considered as the urban congested core that caused the city to lack POS and UGS. A mixed methods approach was considered for data collection, including the study of the utilization pattern of residents, and measuring the actual space allocated for POS of each subdivision. According to the results, Cabanatuan City has only 3.6 square meters of POS per person, indicating a shortfall comparable to Manila’s score in GCI. With a growing population and demand for open space, Cabanatuan City would need to provide at least 114.7 hectares of land designated for POS to achieve a good and healthy environment for its residents.
DOI: 10.15468/dl.sfm7bj
title: Occurrence Download

description: A dataset containing 1559 species occurrences available in GBIF matching the query:
{
 "and" : [
 {
 "and" : [
 "TaxonKey is Fabaceae",
 "HasGeospatialIssue is false"
 ]
 },
 {
 "and" : [
 "BasisOfRecord is one of (Living Specimen, Fossil, Specimen, Material sample)",
 "TaxonKey is one of (Phyllolobium Fisch.)"
 ]
 }
 ]
}

 The dataset includes 1559 records from 47 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0011083-241024112534372/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.bh6fpt
title: Occurrence Download

description: A dataset containing 21034 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Continent is one of (Asia, Africa, Antarctica)",
 "OccurrenceStatus is Present",
 "TaxonKey is Eugenia L."
 ]
}

 The dataset includes 21034 records from 217 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0011084-241024112534372/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.6c5rqm
title: Occurrence Download

description: A dataset containing 220 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Geometry POLYGON((20.2148 57.66414,35.12942 57.78437,36.07242 70.80774,20.19539 70.76345,20.2148 57.66414))",
 "HasGeospatialIssue is false",
 "TaxonKey is Pelophylax ridibundus (Pallas, 1771)"
 ]
}

 The dataset includes 220 records from 12 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0011085-241024112534372/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.17632/4ss9zvf5br.1
title: Development of Real-time Nitrate Detection for Deployment into the Great Barrier Reef Catchment Area

description: Supplementary Material for Development of Real-time Nitrate Detection for Deployment into the Great Barrier Reef Catchment Area:
1. Mendeley DataSet - Stability Experiment
2. Mendeley Video - Prototype automated sensor system
DOI: 10.17632/5xbzr9c8md.1
title: The case report of CODAS syndrome

description: CODAS syndrome is a rare autosomal recessive genetic disorder, with an incidence in children of less than 1 in 1 million. Since the first case was discovered in 1991, only a few cases have been reported worldwide. Currently, there are no drug or medical treatment cases documented for all reported CODAS syndrome cases, including indications and contraindications for medication use. This patient is the first case treated with growth hormone and aromatase inhibitors for CODAS syndrome. We monitored the child's growth and skeletal changes for nearly three years before and after treatment, as well as potential adverse events. This may provide clinical significance for future treatment options in CODAS syndrome patients.
DOI: 10.17632/tj462jgznw.1
title: Meta-data from WoS

description: This study is a bibliometric analysis for tourism photograph studies from 1995 until 2023. The meta-data was conducted from one source, namely Web of Science. Using the PRISMA procedure, the final data used in this study is 147 documents. The meta-data final processed by VOSViewer and Biblioshiny from R.
DOI: 10.17632/ybpby5dygt.1
title: Structural optimizations on the scaffold of 7H-pyrrolo[2,3-d]pyrimidine to develop potent iNOS inhibitors with improved anti- arthritis activity in vivo_Supplement

description: Supplementary data
DOI: 10.17632/gy4hfbm9x9.1
title: Dataset for Role of Autoconversion Parameterization in Coupled Climate Model for Simulating Monsoon Subseasonal Oscillations

description: The datasets are obtained through the model simulation of CFSv2. The data are processed by using different analytical softwares e.g., Ferret, NCL, CDO and GrADS. 
1. CFS stands for NCEP Climate Forecast System Model.
2. t126 stands for resolution of 100 km datasets.
3. t382 stands for resolution of ~38 km datasets
4. ppt stands for precipitation files
5. olr stands for outgoing longwave radiation
6. cloud data contains cloud fraction
7. omega data contains the pressure vertical velocity.
8. active and break composite data are provided. They are calculated applying time average after selecting active and break spell.
DOI: 10.17632/fjzb9pmrxf.1
title: Datasets on Arsenic and Cadmium Contamination in Nigerian Domestic Water

description: This dataset is a compilation of information on the presence of arsenic and cadmium in Nigerian drinking water sources. Arsenic and cadmium are classified as group 1 carcinogens, which pose serious health risks to the public. The data presented were compiled from the review of research articles published between 2010 and 2023 on Nigerian domestic water sources such as groundwater (hand-dug wells, machine wells, and boreholes) and surface water (rivers, streams, and lakes). The sources of the heavy metals were traced to anthropogenic activities and geogenic sources. The anthropogenic activities that give rise to arsenic and cadmium in drinking water sources include industrial waste discharge into the environment, fertilizer applications, and mining. The geogenic causes of arsenic and cadmium in domestic water sources refer to the natural deposits in soils and stream sediments. The study showed that anthropogenic activities accounted for 61% and 68% of arsenic and cadmium pollution in drinking water, respectively, while the remaining cases were attributed to geogenic causes. Some of the studies linked arsenic and cadmium contamination to chronic illnesses such as kidney failures, liver sclerosis, and central nervous problems in Nigeria. This data is important for understanding arsenic and cadmium's pathways, transport processes, and fate. The data can be used by researchers to understand patterns and trends in water contamination. It can also be used by policymakers and health professionals to plan the necessary interventions to remediate the problem. Furthermore, this data can guide the much-needed epidemiological studies to determine the areas where the problem is prevalent and to link the reports of ailments in the affected areas to water contamination by arsenic and cadmium.
DOI: 10.15468/dl.q55buu
title: Occurrence Download

description: A dataset containing 3893 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Geometry POLYGON((-125.03969 40.22798,-115.54538 40.22798,-115.54538 49.22259,-125.03969 49.22259,-125.03969 40.22798))",
 "TaxonKey is Ailanthus altissima (Mill.) Swingle"
 ]
}

 The dataset includes 3893 records from 32 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0011086-241024112534372/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.17632/6p54bscykt.1
title: Data of triaxial tests on hydrate-bearing sediments

description: The stress and volumetric curves of hydrate-bearing sediments under various hydrate dissociation ratios are uploaded
DOI: 10.17632/ftz4x77z4h.1
title: Comparison of caudal wedge ostectomy with cranial wedge ostectomy for treatment of overriding/impinging spinous processes in horses

description: Background:
Caudal wedge ostectomy has not been investigated for treatment of overriding/impinging spinous processes (SPs) in horses. 
Objectives: 
Establish the feasibility of caudal wedge ostectomy using thoracolumbar cadavers. Compare measures of surgical trauma (volume of bone removed and length of ostectomy cut) and error (angle the ostectomy exits the SP and risk of creating a never ending cut) between hypothetical caudal and cranial wedge ostectomies on SPs of different inclinations. 
Study Design:
Experimental, method comparison study
Methods:
Computed tomography and caudal wedge ostectomy surgery were performed on four cadavers. Observations, technical difficulties and surgical errors were recorded. 
Radiographs from 67 horses with overriding/impinging SPs were reviewed. Hypothetical ‘ideal’ caudal and cranial wedge ostectomies, and ‘error’ ostectomies diverging 12˚ from ideal, were drawn at sites of impingement. Ostectomy area/SP width, ostectomy length/SP width, absolute difference of exit angles (angle the ostectomy exits the SP) from 90˚, and number of error ostectomies failing to exit the SP (never-ending-cuts [NEC]) were calculated. Continuous variables were compared between techniques in caudally and cranially inclined SP groups using Wilcoxon signed-rank tests. Proportions of error ostectomies resulting in NEC were compared using McNemar’s tests. 
Results:
No surgical errors were recorded with caudal wedge ostectomy. Median ostectomy area/SP width (measure of ostectomy volume) was lower for caudal compared to cranial wedge ostectomy in caudally and cranially inclined SP groups. Median exit angles were closer to 90˚for caudal compared to cranial wedge ostectomies in caudally and cranially inclined SP group. The proportion of NEC was lower for caudal compared to cranial wedge ostectomy in caudally but not cranially inclined SP groups

Conclusions: 
Experimentally, caudal wedge ostectomy was a feasible technique to perform, removed less bone and resulted in reduced frequency of NEC in caudally inclined SPs. Further investigation of the technique is warranted in vivo.
DOI: 10.17632/35fs9gktx5.1
title: LDHU3_18.2060

description: Protein of unknown function - conserved; Leishmania donovani (HU3 strain)
DOI: 10.17632/y6z3wjrprd.1
title: LDHU3_18.2100

description: Protein of unknown function - conserved; Leishmania donovani (HU3 strain)
DOI: 10.17632/533d5ttydp.1
title: Supplemental material: Evaluation of a fully automated 2D imaging system for real-time cattle lameness detection using machine learning

description: Supplemental material: Evaluation of a fully automated 2D imaging system for real-time cattle lameness detection using machine learning
DOI: 10.17632/k6395ns5pk.1
title: Itaconate transporter SLC13A3 confers immunotherapy resistance via alkylation-mediated stabilization of PD-L1

description: Original western blotting data
DOI: 10.17632/gz8r3spkns.1
title: Handwritten Hindko Language Dataset (HHLD)

description: Dataset consists of 100 Hindko numbers written in words from 1 to 100 so these words were written on pages and every candidate was asked to write these 100 words twice. So 200 samples are taken from every candidate. Every candidate signed an undertaking that he/she have no objection on usage of this writing for academic and research purposes. Then by using advanced scanning machines these pages were scanned by setting dpi on 1200. Then words are cropped by using cropping tool from these scan images and saved into the folders. For every class separate folder is created and labelled from 1 to 100. Every sample is saved into their relevant folder so that 100 folder is used for 100 different words. As size of every image was different so for better results every image is resized into same size that is 50x50 pixels. The dataset consists of 224782 samples. The storage size of image dataset is 394MB and storage size of CSV version of dataset is 1098MB.
DOI: 10.17632/gz8r3spkns.2
title: Handwritten Hindko Language Dataset (HHLD)

description: Dataset consists of 100 Hindko numbers written in words from 1 to 100 so these words were written on pages and every candidate was asked to write these 100 words twice. So 200 samples are taken from every candidate. Every candidate signed an undertaking that he/she have no objection on usage of this writing for academic and research purposes. Then by using advanced scanning machines these pages were scanned by setting dpi on 1200. Then words are cropped by using cropping tool from these scan images and saved into the folders. For every class separate folder is created and labelled from 1 to 100. Every sample is saved into their relevant folder so that 100 folder is used for 100 different words. As size of every image was different so for better results every image is resized into same size that is 50x50 pixels. The dataset consists of 224782 samples. The storage size of image dataset is 394MB and storage size of CSV version of dataset is 1098MB.
DOI: 10.17632/gz8r3spkns.3
title: Handwritten Hindko Digits Dataset (HHDD)

description: Dataset consists of 100 Hindko numbers written in words from 1 to 100 so these words were written on pages and every candidate was asked to write these 100 words twice. So 200 samples are taken from every candidate. Every candidate signed an undertaking that he/she have no objection on usage of this writing for academic and research purposes. Then by using advanced scanning machines these pages were scanned by setting dpi on 1200. Then words are cropped by using cropping tool from these scan images and saved into the folders. For every class separate folder is created and labelled from 1 to 100. Every sample is saved into their relevant folder so that 100 folder is used for 100 different words. As size of every image was different so for better results every image is resized into same size that is 50x50 pixels. The dataset consists of 224782 samples. The storage size of image dataset is 394MB and storage size of CSV version of dataset is 1098MB.