cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.6974414.v20
title: Prospective Age Dataset

description: Computed prospective ages for 1950-2100 for all countries and regions based on 2017 Revision of the UN World Population Prospects.<br>Content:<br>1. <b><i>codebook.pdf </i></b>contains a brief overview of the dataset, its background and a description of the cases and variables.<br>2. <i><b>methods.pdf</b> </i>is a (draft but complete) write up of the calculations used to create the dataset.<br>3.<b><i> 2017_prospective-ages.csv</i></b> is the human readable form of the prospective age dataset containing the calculated prospective old-age thresholds for 241 countries and regions, for the period 1950-2100, for men, women and both together, as well as the proportions of the population (male, female and total) over these thresholds.<br>This figshare fileset is published directly from the github repository ProspectiveAgeData. <br>For an application of this data see the factsheet on ageing in the Middle East and Northern Africa which will be published in Population Horizons journal.
DOI: 10.6084/m9.figshare.6974414.v21
title: Prospective Age Dataset

description: Computed prospective ages for 1950-2100 for all countries and regions based on 2017 Revision of the UN World Population Prospects.<br>Content:<br>1. <b><i>codebook.pdf </i></b>contains a brief overview of the dataset, its background and a description of the cases and variables.<br>2. <i><b>methods.pdf</b> </i>is a (draft but complete) write up of the calculations used to create the dataset.<br>3.<b><i> 2017_prospective-ages.csv</i></b> is the human readable form of the prospective age dataset containing the calculated prospective old-age thresholds for 241 countries and regions, for the period 1950-2100, for men, women and both together, as well as the proportions of the population (male, female and total) over these thresholds.<br>This figshare fileset is published directly from the github repository ProspectiveAgeData. <br>For an application of this data see the factsheet on ageing in the Middle East and Northern Africa which will be published in Population Horizons journal.
DOI: 10.6084/m9.figshare.6974414.v22
title: Prospective Age Dataset

description: Computed prospective ages for 1950-2100 for all countries and regions based on 2017 Revision of the UN World Population Prospects.<br>Content:<br>1. <b><i>codebook.pdf </i></b>contains a brief overview of the dataset, its background and a description of the cases and variables.<br>2. <i><b>methods.pdf</b> </i>is a (draft but complete) write up of the calculations used to create the dataset.<br>3.<b><i> 2017_prospective-ages.csv</i></b> is the human readable form of the prospective age dataset containing the calculated prospective old-age thresholds for 241 countries and regions, for the period 1950-2100, for men, women and both together, as well as the proportions of the population (male, female and total) over these thresholds.<br>This figshare fileset is published directly from the github repository ProspectiveAgeData. <br>For an application of this data see the factsheet on ageing in the Middle East and Northern Africa which will be published in Population Horizons journal.
DOI: 10.6084/m9.figshare.6974414.v23
title: Prospective Age Dataset

description: Computed prospective ages for 1950-2100 for all countries and regions based on 2017 Revision of the UN World Population Prospects.<br>Content:<br>1. <b><i>codebook.pdf </i></b>contains a brief overview of the dataset, its background and a description of the cases and variables.<br>2. <i><b>methods.pdf</b> </i>is a (draft but complete) write up of the calculations used to create the dataset.<br>3.<b><i> 2017_prospective-ages.csv</i></b> is the human readable form of the prospective age dataset containing the calculated prospective old-age thresholds for 241 countries and regions, for the period 1950-2100, for men, women and both together, as well as the proportions of the population (male, female and total) over these thresholds.<br>This figshare fileset is published directly from the github repository ProspectiveAgeData. <br>For an application of this data see the factsheet on ageing in the Middle East and Northern Africa which will be published in Population Horizons journal.
DOI: 10.6084/m9.figshare.6974414.v25
title: Prospective Age Dataset

description: Computed prospective ages for 1950-2100 for all countries and regions based on 2017 Revision of the UN World Population Prospects.<br>Content:<br>1. <b><i>codebook.pdf </i></b>contains a brief overview of the dataset, its background and a description of the cases and variables.<br>2. <i><b>methods.pdf</b> </i>is a (draft but complete) write up of the calculations used to create the dataset.<br>3.<b><i> 2017_prospective-ages.csv</i></b> is the human readable form of the prospective age dataset containing the calculated prospective old-age thresholds for 241 countries and regions, for the period 1950-2100, for men, women and both together, as well as the proportions of the population (male, female and total) over these thresholds.<br>This figshare fileset is published directly from the github repository ProspectiveAgeData. <br>For an application of this data see the factsheet on ageing in the Middle East and Northern Africa which will be published in Population Horizons journal.
DOI: 10.6084/m9.figshare.6974285
title: Epigenetic alterations associated with early prenatal dexamethasone treatment: Supplementary Table 1 & 2

description: Supplementary Table 1: Task performances from Wechsler subscales (WAIS and WMS) and the Stroop subscale ‘interference’ with mean raw scores, standard deviations and <i>p</i>-values. Significant associations between cognitive performance and β-values or β-values x sex are marked in bold.<br>Supplementary Table 2: Significantly enriched gene ontology terms from GREAT analysis<br>
DOI: 10.6084/m9.figshare.6974414.v24
title: Prospective Age Dataset

description: Computed prospective ages for 1950-2100 for all countries and regions based on 2017 Revision of the UN World Population Prospects.<br>Content:<br>1. <b><i>codebook.pdf </i></b>contains a brief overview of the dataset, its background and a description of the cases and variables.<br>2. <i><b>methods.pdf</b> </i>is a (draft but complete) write up of the calculations used to create the dataset.<br>3.<b><i> 2017_prospective-ages.csv</i></b> is the human readable form of the prospective age dataset containing the calculated prospective old-age thresholds for 241 countries and regions, for the period 1950-2100, for men, women and both together, as well as the proportions of the population (male, female and total) over these thresholds.<br>This figshare fileset is published directly from the github repository ProspectiveAgeData. <br>For an application of this data see the factsheet on ageing in the Middle East and Northern Africa which will be published in Population Horizons journal.
DOI: 10.6084/m9.figshare.6974282
title: Fox 2018 images, models and software

description: Images, source data and software associated with publication:<b>Fox <i>et al</i>, 2018, Spatiotemporal coordination of cell division and growth during organ morphogenesis. PLOS Biology DOI 10.1371/journal.pbio.2005952</b><br>
DOI: 10.6084/m9.figshare.6974285.v1
title: Epigenetic alterations associated with early prenatal dexamethasone treatment: Supplementary Table 1 & 2

description: Supplementary Table 1: Task performances from Wechsler subscales (WAIS and WMS) and the Stroop subscale ‘interference’ with mean raw scores, standard deviations and <i>p</i>-values. Significant associations between cognitive performance and β-values or β-values x sex are marked in bold.<br>Supplementary Table 2: Significantly enriched gene ontology terms from GREAT analysis<br>
DOI: 10.6084/m9.figshare.6974282.v1
title: Fox 2018 images, models and software

description: Imagess and software associated with publication:<b>Fox <i>et al</i>, 2018, Spatiotemporal coordination of cell division and growth during organ morphogenesis. PLOS Biology DOI 10.1371/journal.pbio.2005952</b><br>
DOI: 10.6084/m9.figshare.6974114
title: Youth data and scripts.zip

description: Data includes the data and scripts used for the analyses.
DOI: 10.6084/m9.figshare.6974282.v2
title: Fox 2018 images, models and software

description: Imagess and software associated with publication:<b>Fox <i>et al</i>, 2018, Spatiotemporal coordination of cell division and growth during organ morphogenesis. PLOS Biology DOI 10.1371/journal.pbio.2005952</b><br>
DOI: 10.6084/m9.figshare.6974114.v1
title: Youth data and scripts.zip

description: Data includes the data and scripts used for the analyses.
DOI: 10.6084/m9.figshare.6974282.v3
title: Fox 2018 images, models and software

description: Imagess and software associated with publication:<b>Fox <i>et al</i>, 2018, Spatiotemporal coordination of cell division and growth during organ morphogenesis. PLOS Biology DOI 10.1371/journal.pbio.2005952</b><br>
DOI: 10.6084/m9.figshare.6974093.v1
title: SNP data from Neurospora intermedia

description: This dataset contains a VCF file with SNPs from 21 <i>Neurospora intermedia</i> and 5 <i>N. metzenbergii</i> strains mapped to the genome assembly of <i>N. intermedia</i> strain 8807.<br>SNPs are generated from raw paired-end reads which have been deposited to the Sequence Read Archive (SRA) in BioProjects PRJNA486257 (http://www.ncbi.nlm.nih.gov/bioproject/486257).<br>See Svedberg et al., (2018) "Convergent evolution of complex genomic rearrangements in two fungal meiotic drive elements" for further information: https://www.nature.com/articles/s41467-018-06562-x (DOI:10.1038/s41467-018-06562-x)Supplementary Table 11 contains Illumina sequencing statistics.<br><br>Full list of strains: 10411, 1785, 1786, 1787, 1795, 1832, 1938, 2316, 2365, 3194, 5119, 5124, 6249, 6263, 6595, 6795, 7402, 7426, 7427, 7429, 8761, 8767, 8769, 8793, 8853, P4149<br><br>All strains are referred to by their ID numbers at the Fungal Genetics Stock Center (www.fgsc.net), where they also can be ordered.<br>The reference genome of strain 8807 was released with the paper: <br> Sun et al. (2017). Large-scale suppression of recombination predates genomic rearrangements in Neurospora tetrasperma. Nature Communications <i>8</i>, 1140. (https://www.nature.com/articles/s41467-017-01317-6)It can be downloaded here:<br>Sun, Yu; Svedberg, Jesper; Hiltunen, Markus; Corcoran, Pádraic; Johannesson, Hanna (2017): High-quality Neurospora tetrasperma genome assemblies. figshare. Dataset.https://figshare.com/articles/High-quality_Neurospora_tetrasperma_genome_assemblies/5327515<br>
DOI: 10.6084/m9.figshare.6974282.v4
title: Fox 2018 images, models and software

description: Imagess and software associated with publication:<b>Fox <i>et al</i>, 2018, Spatiotemporal coordination of cell division and growth during organ morphogenesis. PLOS Biology DOI 10.1371/journal.pbio.2005952</b><br>
DOI: 10.6084/m9.figshare.6974282.v5
title: Fox 2018 images, models and software

description: Images, source data and software associated with publication:<b>Fox <i>et al</i>, 2018, Spatiotemporal coordination of cell division and growth during organ morphogenesis. PLOS Biology DOI 10.1371/journal.pbio.2005952</b><br>
DOI: 10.6084/m9.figshare.6974282.v7
title: Fox 2018 images, models and software

description: Images, source data and software associated with publication:<b>Fox <i>et al</i>, 2018, Spatiotemporal coordination of cell division and growth during organ morphogenesis. PLOS Biology DOI 10.1371/journal.pbio.2005952</b><br>
DOI: 10.6084/m9.figshare.6974282.v6
title: Fox 2018 images, models and software

description: Images, source data and software associated with publication:<b>Fox <i>et al</i>, 2018, Spatiotemporal coordination of cell division and growth during organ morphogenesis. PLOS Biology DOI 10.1371/journal.pbio.2005952</b><br>
DOI: 10.6084/m9.figshare.6974048
title: Conifer plantations in grassland and subtropical forest: Does spider diversity respond different to edge effect?

description: Two adjacent habitats separated by an abrupt transition often cause strong alterations in environmental conditions resulting in what is called the edge effect. The structural similarity between the adjacent habitats determines how abrupt the transition is. We explored the response of spider communities to the edge effect in mature pine plantations and compared for the first time those responses in contrasting biomes (subtropical forest and grassland) in southern South America. We expect that the higher the contrast between the natural habitat and the conifer plantation, the higher will be the magnitude and the lower the extent of the response of species richness and abundance to edge effect. We sampled spiders using pitfall traps located from the edge to the plantation interior, and environmental variables were measured in pine plantations (<i>Pinus taeda</i>) adjacent to native grassland and subtropical forest. Results revealed that wandering spiders were sensitive to edge effect in both subtropical forest and grassland, primarily reflected by a decline in the abundance toward plantation interiors. However, the magnitude and the extent of spider abundance response to the edge effect were similar between pine plantations developing in forest and grasslands biomes. Microclimatic conditions and vegetation cover partially explained species abundance from the edge to plantation interior. Our findings suggest that conifer plantations would promote spider richness if a wide range of microhabitats were provided and support the use of spider abundance to assess edge effect in forested landscapes.
DOI: 10.6084/m9.figshare.6974048.v1
title: Conifer plantations in grassland and subtropical forest: Does spider diversity respond different to edge effect?

description: Two adjacent habitats separated by an abrupt transition often cause strong alterations in environmental conditions resulting in what is called the edge effect. The structural similarity between the adjacent habitats determines how abrupt the transition is. We explored the response of spider communities to the edge effect in mature pine plantations and compared for the first time those responses in contrasting biomes (subtropical forest and grassland) in southern South America. We expect that the higher the contrast between the natural habitat and the conifer plantation, the higher will be the magnitude and the lower the extent of the response of species richness and abundance to edge effect. We sampled spiders using pitfall traps located from the edge to the plantation interior, and environmental variables were measured in pine plantations (<i>Pinus taeda</i>) adjacent to native grassland and subtropical forest. Results revealed that wandering spiders were sensitive to edge effect in both subtropical forest and grassland, primarily reflected by a decline in the abundance toward plantation interiors. However, the magnitude and the extent of spider abundance response to the edge effect were similar between pine plantations developing in forest and grasslands biomes. Microclimatic conditions and vegetation cover partially explained species abundance from the edge to plantation interior. Our findings suggest that conifer plantations would promote spider richness if a wide range of microhabitats were provided and support the use of spider abundance to assess edge effect in forested landscapes.
DOI: 10.6084/m9.figshare.6974033.v1
title: PacBio based genome assemblies of Neurospora intermedia spore killer strains

description: High-quality genome assemblies of six Neurospora intermedia strains, based on PacBio RSII long-read sequencing data.<br>See Svedberg et al., (2018) "Convergent evolution of complex genomic rearrangements in two fungal meiotic drive elements" for further information: https://www.nature.com/articles/s41467-018-06562-x (DOI:10.1038/s41467-018-06562-x) Table 1 contains statistics for the PacBio sequencing and assemblies.<br><br>Raw PacBio reads have been deposited in the Sequence Read Archive (SRA) in BioProjects PRJNA486257 (http://www.ncbi.nlm.nih.gov/bioproject/486257).<br>Five of the strains carry Spore Killer meiotic drive elements, and one is sensitive to spore killing.<br>All strains can be ordered from the Fungal Genetics Stock Center at http://www.fgsc.net/ <br><br><b>Strains</b><br>FGSC number: 8761Phenotype: sensitive<br>Assembly: Nint.8761pb.corr.order.fasta.gz<br>FGSC number: 7401Phenotype: Sk-2<br>Assembly: Nint.sk2-7401pb.order.fasta.gz<br><br>FGSC number: 7426Phenotype: Sk-2<br>Assembly: Nint.sk2-7426pb.order.corr.fasta.gz<br><br>FGSC number: 7427Phenotype: Sk-2<br>Assembly: Nint.sk2-7427pb.order.corr.fasta.gz<br><br>FGSC number: 7429Phenotype: Sk-2<br>Assembly: Nint.sk2-7429pb.order.corr.fasta.gz<br><br>FGSC number: 3194Phenotype: Sk-3<br>Assembly: Nint.sk3-3194pb.order.corr.fasta.gz<br>
DOI: 10.6084/m9.figshare.6974012
title: Supplementary Material for: Anti-Cancer Effects of Radix Angelica Sinensis (Danggui) and N-Butylidenephthalide on Gastric Cancer: Implications for REDD1 Activation and mTOR Inhibition

description: <b><i>Background/Aims:</i></b> <i>Radix Angelica Sinensis</i> (danggui in Chinese) is widely used in traditional chinese medicine (TCM). N-butylidenephthalide (BP), a bioactive compound in <i>danggui</i>, is a potential antitumor agent for various cancer types. However, its clinical effect and mechanism in the treatment of gastric cancer remain undetermined. <b><i>Methods:</i></b> The <i>in vivo</i> protective effect of <i>danggui</i> in patients with gastric cancer were validated using data from Taiwan’s National Health Insurance Research Database (NHIRD). The genes induced by BP-treatment were analyzed by whole transcriptome RNA sequencing (RNA-seq) and validated by real-time PCR, western blot and siRNA transfection. The effect of BP on AGS cell migration and invasion was evaluated in transwell assays. The antitumor effects of BP were evaluated <i>in vivo</i> in an AGS xenograft animal model. <b><i>Results:</i></b> <i>Danggui</i> users were found to have an increased survival rate when compared with <i>danggui</i> nonusers (log-rank test <i>p</i> = 0.002) . The use of <i>danggui</i> highly associated with decreased mortality (the adjusted hazard ratio (HR) of <i>danggui</i> user was 0.72 [95 % CI, 0.57-0.92] (<i>p</i> = 0.009). The <i>in vitro</i> results showed that BP inhibited gastric cancer cell proliferation, and triggered cellular apoptosis depending on the activation of mitochondrial apoptotic pathway. Using RNA-seq analysis we found that REDD1 was the highest transcript induced by BP in gastric cancer cells. BP induce an increase of REDD1 expression that inhibits mTOR signaling, thus inhibiting gastric cancer growth. We used RNA interference to demonstrate that the knock-down of REDD1 attenuated the BP-induced mTORC1 activation and growth inhibition. BP suppressed the growth of AGS xenografts tumor <i>in vivo</i>. <b><i>Conclusion:</i></b> <i>Danggui</i> can prolong the survival rate of gastric cancer patients in Taiwan. BP caused gastric cancer cell death through the activation of mitochondria-intrinsic pathway and induced the REDD1 expression leading to mTOR signal pathway inhibition in gastric cancer cells. BP inhibited the <i>in vivo</i> growth of AGS xenograft tumors. These results may provide the basis for a new therapeutic approach toward the treatment of gastric cancer progression.
DOI: 10.6084/m9.figshare.6973910
title: Supplementary Material for: <b><i>ANTXR1</i></b> Intronic Variants Are Associated with Fetal Hemoglobin in the Arab-Indian Haplotype of Sickle Cell Disease

description: Disease severity of sickle cell anemia is highly variable, and it is commonly accepted that fetal hemoglobin (HbF) levels play a major role as an ameliorating factor. Investigation of genetic variants have identified several genes to be the principal influencers of HbF regulation. Here, we further elucidated the association of rs4527238 and rs35685045 of <i>ANTXR1</i> genes in the context of HbF level variance in sickle cell anemia patients of the Arab-Indian haplotype. Samples from 630 sickle cell anemia patients were analyzed for the mutations at 2 specific locations of the <i>ANTXR1</i> gene by TaqMan®-based real-time PCR. The CC genotype (<i>p</i> = 0.018) of rs4527238 and the TT genotype (<i>p</i> = 0.048) of rs35685045 of <i>ANTXR1</i> were found to be significantly associated with low HbF expression. The frequency of the CC genotype of rs4527238 was observed to be high in the low HbF patient group compared to the high HbF group (<i>p</i> = 0.009). Likewise, the frequency of the TT genotype of rs35685045 was also high among the low HbF group (<i>p</i> = 0.017). The <i>ANTXR1</i> genetic mutations and the association with HbF expression in the Arab-Indian haplotype sickle cell patients revealed that the <i>ANTXR1</i> gene may be a major HbF modulator leading to potential therapeutic options that should be further explored.
DOI: 10.6084/m9.figshare.6973892
title: Potential value of patient record review to assess and improve patient safety in general practice: A systematic review

description: <b>Background:</b> There is limited research, and guidance, on how to address safety in general practice proactively. <b>Objectives:</b> This review aimed to synthesize the literature describing the use of patient record review (PRR) to measure and improve patient safety in primary care. The PRR methodologies utilized and the resulting outcomes were examined. <b>Methods:</b> Searches were conducted using Medline, Embase, CINAHL and PsycINFO in February 2017. Reference lists of included studies and existing review papers were also screened. English language, peer-reviewed studies that utilized PRR to identify patient safety incidents (PSIs) occurring in general practice were included. Two researchers independently extracted data from articles and applied the Quality Assessment Tool for Studies with Diverse Designs. <b>Results:</b> A total of 3265 studies were screened, with 15 included. Trigger tools were the most frequent method used for the PRRs (<i>n</i> = 6). The mean number of safety incidents per 100 records was 12.6. Within studies, a mean of 30.6% of incidents were associated with severe harm (range 8.6–50%), and a mean of 55.6% of incidents was considered preventable (range 32.7–93.5%). The most commonly identified types of PSIs related to medication and prescribing, diagnosis, communication and treatment. Three studies reported on improvement actions taken after the PRRs. <b>Conclusion:</b> This review suggests that PRR may be a promising means of proactively identifying patient safety incidents and informing improvements.
DOI: 10.6084/m9.figshare.6973910.v1
title: Supplementary Material for: <b><i>ANTXR1</i></b> Intronic Variants Are Associated with Fetal Hemoglobin in the Arab-Indian Haplotype of Sickle Cell Disease

description: Disease severity of sickle cell anemia is highly variable, and it is commonly accepted that fetal hemoglobin (HbF) levels play a major role as an ameliorating factor. Investigation of genetic variants have identified several genes to be the principal influencers of HbF regulation. Here, we further elucidated the association of rs4527238 and rs35685045 of <i>ANTXR1</i> genes in the context of HbF level variance in sickle cell anemia patients of the Arab-Indian haplotype. Samples from 630 sickle cell anemia patients were analyzed for the mutations at 2 specific locations of the <i>ANTXR1</i> gene by TaqMan®-based real-time PCR. The CC genotype (<i>p</i> = 0.018) of rs4527238 and the TT genotype (<i>p</i> = 0.048) of rs35685045 of <i>ANTXR1</i> were found to be significantly associated with low HbF expression. The frequency of the CC genotype of rs4527238 was observed to be high in the low HbF patient group compared to the high HbF group (<i>p</i> = 0.009). Likewise, the frequency of the TT genotype of rs35685045 was also high among the low HbF group (<i>p</i> = 0.017). The <i>ANTXR1</i> genetic mutations and the association with HbF expression in the Arab-Indian haplotype sickle cell patients revealed that the <i>ANTXR1</i> gene may be a major HbF modulator leading to potential therapeutic options that should be further explored.