cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.7899887.v1
title: Association of exercise training and angiotensin-converting enzyme 2 activator improves baroreflex sensitivity of spontaneously hypertensive rats

description: The present study sought to determine cardiovascular effects of aerobic training associated with diminazene aceturate (DIZE), an activator of the angiotensin converting enzyme 2, in spontaneously hypertensive rats (SHRs). Male SHRs (280–350 g) were either subjected to exercise training or not (sedentary group). The trained group was subjected to 8 weeks of aerobic training on a treadmill (five times a week, lasting 60 min at an intensity of 50–60% of maximum aerobic speed). In the last 15 days of the experimental protocol, these groups were redistributed into four groups: i) sedentary SHRs with daily treatment of 1 mg/kg DIZE (S+D1); ii) trained SHRs with daily treatment of 1 mg/kg DIZE (T+D1); iii) sedentary SHRs with daily treatment of vehicle (S+V); and iv) trained SHRs with daily treatment of vehicle (T+V). After treatment, SHRs were anesthetized and subjected to artery and femoral vein cannulation prior to the implantation of ECG electrode. After 24 h, mean arterial pressure (MAP) and heart rate (HR) were recorded; the baroreflex sensitivity and the effect of double autonomic blockade (DAB) were evaluated in non-anesthetized SHRs. DIZE treatment improved baroreflex sensitivity in the T+D1 group as compared with the T+V and S+D1 groups. The intrinsic heart rate (IHR) and MAP were reduced in T+D1 group as compared with T+V and S+D1 groups. Hence, we conclude that the association of exercise training with DIZE treatment improved baroreflex function and cardiovascular regulation.
DOI: 10.6084/m9.figshare.7899890.v1
title: Comparison of conventional Papanicolaou cytology samples with liquid-based cervical cytology samples from women in Pernambuco, Brazil

description: In the present study, we compared the performance of a ThinPrep cytological method with the conventional Papanicolaou test for diagnosis of cytopathological changes, with regard to unsatisfactory results achieved at the Central Public Health Laboratory of the State of Pernambuco. A population-based, cross-sectional study was performed with women aged 18 to 65 years, who spontaneously sought gynecological services in Public Health Units in the State of Pernambuco, Northeast Brazil, between April and November 2011. All patients in the study were given a standardized questionnaire on sociodemographics, sexual characteristics, reproductive practices, and habits. A total of 525 patients were assessed by the two methods (11.05% were under the age of 25 years, 30.86% were single, 4.4% had had more than 5 sexual partners, 44% were not using contraception, 38.85% were users of alcohol, 24.38% were smokers, 3.24% had consumed drugs previously, 42.01% had gynecological complaints, and 12.19% had an early history of sexually transmitted diseases). The two methods showed poor correlation (k=0.19; 95%CI=0.11–0.26; P&lt;0.001). The ThinPrep method reduced the rate of unsatisfactory results from 4.38% to 1.71% (χ2=5.28; P=0.02), and the number of cytopathological changes diagnosed increased from 2.47% to 3.04%. This study confirmed that adopting the ThinPrep method for diagnosis of cervical cytological samples was an improvement over the conventional method. Furthermore, this method may reduce possible losses from cytological resampling and reduce obstacles to patient follow-up, improving the quality of the public health system in the State of Pernambuco, Northeast Brazil.
DOI: 10.6084/m9.figshare.7899893
title: Reconfiguration of multi-stage tensegrity structures using infinitesimal mechanisms

description: Abstract The use of tensegrity structures in soft robotics has seen an increased interest in recent years thanks to their mechanical properties, but the control of these systems remains an open problem. This paper presents a reconfiguration strategy for actuated multi-stage tensegrity structures. The algorithm works on the principle of using the infinitesimal mechanisms of the structure to generate a path of positions along which a multi-stage tensegrity structure can change its shape while maintaining the self-equilibrium. Combining the force density method with a marching procedure, the solution to the equilibrium problem is given by a set of differential equations that define the kinematic constraints of the structure. Beginning from an initial stable position, the algorithm calculates a small displacement until a new stable configuration is reached, and recurrently repeats the process during a given interval of time. By means of three numerical examples, we show the efficacy of our algorithm for reconfiguring a two-stage tensegrity mast along different directions.
DOI: 10.6084/m9.figshare.7899872
title: Early neonatal echocardiographic findings in an experimental rabbit model of congenital diaphragmatic hernia

description: This study aimed to demonstrate that congenital diaphragmatic hernia (CDH) results in vascular abnormalities that are directly associated with the severity of pulmonary hypoplasia and hypertension. These events increase right ventricle (RV) afterload and may adversely affect disease management and patient survival. Our objective was to investigate cardiac function, specifically right ventricular changes, immediately after birth and relate them to myocardial histological findings in a CDH model. Pregnant New Zealand rabbits underwent the surgical procedure at 25 days of gestation (n=14). CDH was created in one fetus per horn (n=16), and the other fetuses were used as controls (n=20). At term (30 days), fetuses were removed, immediately dried and weighed before undergoing four-parameter echocardiography. The lungs and the heart were removed, weighed, and histologically analyzed. CDH animals had smaller total lung weight (P&lt;0.005), left lung weight (P&lt;0.005), and lung-to-body ratio (P&lt;0.005). Echocardiography revealed a smaller left-to-right ventricle ratio (LV/RV, P&lt;0.005) and larger diastolic right ventricle size (DRVS, P&lt;0.007). Histologic analysis revealed a larger number of myocytes undergoing mitotic division (186 vs 132, P&lt;0.05) in CDH hearts. Immediate RV dilation of CDH hearts is related to myocyte mitosis increase. This information may aid the design of future strategies to address pulmonary hypertension in CDH.
DOI: 10.6084/m9.figshare.7899878.v1
title: Grain yield, efficiency and the allocation of foliar N applied to soybean canopies

description: ABSTRACT: Soybean [Glycine max (L.) Merr.] grain yield is closely associated with the level of optimal nitrogen (N) supply, especially during the reproductive stages. Foliar fertilization with low rates of N have been considered as a strategy for furnishing additional N and enhancing grain yields. Field studies using 15N tracer were conducted over two growing seasons to investigate the impact of foliar N fertilization on grain yield, plant N content, the amount of N derived from fertilizer (NDFF) and N recovery efficiency (NRE). Four foliar N rates (0, 1300, 2600 and 3900 g ha−1) were supplied by two equal split applications at the R1 and R3 stages. Foliar N fertilization of soybean canopies did not affect grain yield, grain N content, shoot N content nor plant N content. Total NDFF was increased from 0.7 to 2.0 kg ha−1 across the N rates. Nonetheless, NRE was unaffected by foliar N fertilization, which averaged 53 %. Soybean plants allocated the same amount of N fertilizer to both grains and shoots. No significant effects of low rate foliar N fertilization were registered on soybean grain yield nor plant N content, despite considerable N fertilizer recovery by plant organs.
DOI: 10.6084/m9.figshare.7899881.v1
title: Anthelmintic resistance of injectable macrocyclic lactones in cattle: A systematic review and meta-analysis

description: Abstract The purpose of this work was to identify, critically assess, and summarize available data from primary research about the anthelmintic resistance of injectable macrocyclic lactones in cattle. Meta-analysis was performed to estimate the pooled Odds Ratio and 95% Confidence Intervals. Of the 1504 abstracts screened for eligibility, 80 were deemed relevant for full publication review. Thirteen publications were included in the qualitative synthesis and assessed for systematic bias. Only five studies were included in the quantitative analysis because they showed a low risk of producing biased results in all the parameters. The forest plot indicated four studies that discuss anthelmintic resistance (P&lt;0.05), while only one study did not discuss anthelmintic resistance (P&lt;0.05). The pooled estimate showed 0.59 (95% Confidence intervals: 0.08, 0.47) times higher odds for studies that report anthelmintic resistance than for studies reporting efficacious anthelmintic treatment, with significant and substantially low heterogeneity (I2=25%). Anthelmintic resistance to injectable macrocyclic lactones is a reality. There are need to improve methodological reporting in studies, which is a problem for investigations that involves systematic review and meta-analysis (SR-MA).
DOI: 10.6084/m9.figshare.7899866
title: Structural heart disease as the cause of syncope

description: We described the clinical evolution of patients with structural heart disease presenting at the emergency room with syncope. Patients were stratified according to their syncope etiology and available scores for syncope prognostication. Cox proportional hazard models were used to investigate the relationship between etiology of the syncope and event-free survival. Of the 82,678 emergency visits during the study period, 160 (0.16%) patients were there due to syncope, having a previous diagnosis of structural heart disease. During the median follow-up of 33.8±13.8 months, mean age at the qualifying syncope event was 68.3 years and 40.6% of patients were male. Syncope was vasovagal in 32%, cardiogenic in 57%, orthostatic hypotension in 6%, and of unknown causes in 5% of patients. The primary composite endpoint death, readmission, and emergency visit in 30 days was 39.4% in vasovagal syncope and 60.6% cardiogenic syncope (P&lt;0.001). Primary endpoint-free survival was lower for patients with cardiogenic syncope (HR=2.97, 95%CI=1.94-4.55; P&lt;0.001). The scores were analyzed for diagnostic performance with area under the curve (AUC) and did not help differentiate patients with an increased risk of adverse events. The differential diagnosis of syncope causes in patients with structural heart disease is important, because vasovagal and postural hypotension have better survival and less probability of emergency room or hospital readmission. The available scores are not reliable tools for prognosis in this specific patient population.
DOI: 10.6084/m9.figshare.7899872.v1
title: Early neonatal echocardiographic findings in an experimental rabbit model of congenital diaphragmatic hernia

description: This study aimed to demonstrate that congenital diaphragmatic hernia (CDH) results in vascular abnormalities that are directly associated with the severity of pulmonary hypoplasia and hypertension. These events increase right ventricle (RV) afterload and may adversely affect disease management and patient survival. Our objective was to investigate cardiac function, specifically right ventricular changes, immediately after birth and relate them to myocardial histological findings in a CDH model. Pregnant New Zealand rabbits underwent the surgical procedure at 25 days of gestation (n=14). CDH was created in one fetus per horn (n=16), and the other fetuses were used as controls (n=20). At term (30 days), fetuses were removed, immediately dried and weighed before undergoing four-parameter echocardiography. The lungs and the heart were removed, weighed, and histologically analyzed. CDH animals had smaller total lung weight (P&lt;0.005), left lung weight (P&lt;0.005), and lung-to-body ratio (P&lt;0.005). Echocardiography revealed a smaller left-to-right ventricle ratio (LV/RV, P&lt;0.005) and larger diastolic right ventricle size (DRVS, P&lt;0.007). Histologic analysis revealed a larger number of myocytes undergoing mitotic division (186 vs 132, P&lt;0.05) in CDH hearts. Immediate RV dilation of CDH hearts is related to myocyte mitosis increase. This information may aid the design of future strategies to address pulmonary hypertension in CDH.
DOI: 10.6084/m9.figshare.7899893.v1
title: Reconfiguration of multi-stage tensegrity structures using infinitesimal mechanisms

description: Abstract The use of tensegrity structures in soft robotics has seen an increased interest in recent years thanks to their mechanical properties, but the control of these systems remains an open problem. This paper presents a reconfiguration strategy for actuated multi-stage tensegrity structures. The algorithm works on the principle of using the infinitesimal mechanisms of the structure to generate a path of positions along which a multi-stage tensegrity structure can change its shape while maintaining the self-equilibrium. Combining the force density method with a marching procedure, the solution to the equilibrium problem is given by a set of differential equations that define the kinematic constraints of the structure. Beginning from an initial stable position, the algorithm calculates a small displacement until a new stable configuration is reached, and recurrently repeats the process during a given interval of time. By means of three numerical examples, we show the efficacy of our algorithm for reconfiguring a two-stage tensegrity mast along different directions.
DOI: 10.6084/m9.figshare.7899863
title: Digital Games and Improvement of the Inhibitory Control: a Study With Children in Specialized Educational Service

description: ABSTRACT: Interaction with digital games can have an impact on executive functions and offer contributions to education. Among the dimensions of the executive functions, we highlight inhibitory control and its importance for self-control, selective attention, impulse control and behavioral adjustment. Therefore, interventions were proposed in the Specialized Educational Service (SES), with the support of the family for the use of digital games in the school context for the purpose of exercising executive functions. The objective was to evaluate the contributions of the use of digital games as a complementary strategy in SES, aimed at children who were identified by the teachers as having difficulties in the performance of the inhibitory control. For that, it was performed a quasi-experimental study of mixed approach with 8 children divided into a participant and control group, who were evaluated before and after interventions based on performance in proposed playful activities and psychological test application. The results indicated superior improvement in general, in the participant group when compared to the control group that did not participate in the interventions with the digital games. In the playful activities, they showed greater assertiveness, control of actions and performance. In the tests, it was observed better performance when comparing the pre and post interventions and the groups in four of the five tests applied. It is concluded that digital games can be used as an alternative intervention in SES to enhance executive functions and improve the conditions for learning in the school context.
DOI: 10.6084/m9.figshare.7899863.v1
title: Digital Games and Improvement of the Inhibitory Control: a Study With Children in Specialized Educational Service

description: ABSTRACT: Interaction with digital games can have an impact on executive functions and offer contributions to education. Among the dimensions of the executive functions, we highlight inhibitory control and its importance for self-control, selective attention, impulse control and behavioral adjustment. Therefore, interventions were proposed in the Specialized Educational Service (SES), with the support of the family for the use of digital games in the school context for the purpose of exercising executive functions. The objective was to evaluate the contributions of the use of digital games as a complementary strategy in SES, aimed at children who were identified by the teachers as having difficulties in the performance of the inhibitory control. For that, it was performed a quasi-experimental study of mixed approach with 8 children divided into a participant and control group, who were evaluated before and after interventions based on performance in proposed playful activities and psychological test application. The results indicated superior improvement in general, in the participant group when compared to the control group that did not participate in the interventions with the digital games. In the playful activities, they showed greater assertiveness, control of actions and performance. In the tests, it was observed better performance when comparing the pre and post interventions and the groups in four of the five tests applied. It is concluded that digital games can be used as an alternative intervention in SES to enhance executive functions and improve the conditions for learning in the school context.
DOI: 10.6084/m9.figshare.7899857
title: Inflammatory biomarkers responses after acute whole body vibration in fibromyalgia

description: The aims of this study were 1) to characterize the intensity of the vibration stimulation in women diagnosed with fibromyalgia (FM) compared to a control group of healthy women (HW) matched by age and anthropometric parameters, and 2) to investigate the effect of a single session of whole body vibration (WBV) on inflammatory responses. Levels of adipokines, soluble tumor necrosis factor receptors (sTNFr1, sTNFr2), and brain-derived neurotrophic factor (BDNF) were determined by enzyme-linked immunosorbent assay. Oxygen consumption (VO2) was estimated by a portable gas analysis system, heart rate (HR) was measured using a HR monitor, and perceived exertion (RPE) was evaluated using the Borg scale of perceived exertion. Acutely mild WBV increased VO2 and HR similarly in both groups. There was an interaction (disease vs vibration) in RPE (P=0.0078), showing a higher RPE in FM compared to HW at rest, which further increased in FM after acute WBV, whereas it remained unchanged in HW. In addition, there was an interaction (disease vs vibration) in plasma levels of adiponectin (P=0.0001), sTNFR1 (P=0.000001), sTNFR2 (P=0.0052), leptin (P=0.0007), resistin (P=0.0166), and BDNF (P=0.0179). In conclusion, a single acute session of mild and short WBV can improve the inflammatory status in patients with FM, reaching values close to those of matched HW at their basal status. The neuroendocrine mechanism seems to be an exercise-induced modulation towards greater adaptation to stress response in these patients.
DOI: 10.6084/m9.figshare.7899848
title: Low vaspin levels are related to endothelial dysfunction in patients with ankylosing spondylitis

description: Vaspin is a novel adipocytokine associated with glucose tolerance and chronic inflammation. Some studies reveal that vaspin may be involved in cardiovascular diseases. Our objective was to investigate the relationship between serum vaspin levels and endothelial function in patients with ankylosing spondylitis. One hundred and twenty patients with newly diagnosed ankylosing spondylitis and 100 healthy subjects were studied. Serum vaspin levels were measured with enzyme-linked immunosorbent assay. High resolution ultrasound was used to measure brachial artery diameter at rest, after reactive hyperemia (flow-mediated dilation, FMD) and after sublingual glyceryltrinitrate. Serum vaspin level in patients was 1.92±1.03 ng/mL, which was significantly lower than that in healthy subjects (2.88±0.81 ng/mL). By dividing the distribution of serum vaspin levels into quartiles, FMD levels increased gradually with the increase of serum vaspin levels in patients (P&lt;0.01). Univariate analysis showed a correlation between vaspin and FMD (r=0.73, P=0.003), low-density lipoprotein cholesterol (r=-0.45, P=0.033), high-density lipoprotein cholesterol (r=0.63, P=0.025), fasting blood glucose (r=-0.79, P=0.006), triglycerides (TG) (r=-0.68, P=0.036), systolic blood pressure (r=-0.35, P=0.021), C-reactive protein (r=-0.67, P=0.011), homeostatic model assessment of insulin resistance (HOMA-IR) (r=-0.77, P=0.023) and erythrocyte sedimentation rate (r=-0.88, P=0.039) in patients. Multivariate analysis indicated that serum vaspin levels were independently associated with FMD, HOMA-IR and TG in patients. Our study found that serum vaspin levels were decreased in patients with ankylosing spondylitis and were associated with FMD levels. Vaspin may serve as an independent marker for detecting early stage atherosclerosis in patients with ankylosing spondylitis.
DOI: 10.6084/m9.figshare.7899851
title: Meta-analysis of the efficacy of proton pump inhibitors for the symptoms of laryngopharyngeal reflux

description: The objective of this study was to perform a systematic review and meta-analysis to assess the effectiveness of proton pump inhibitors (PPI) for reflux disease in adult patients with laryngopharyngeal symptoms. A comprehensive search of Cochrane Library, EMBASE, Ovid EBM Reviews, and PubMed was performed for English-language literature about laryngopharyngeal reflux (LPR), in September 2014. The papers were filtered using pre-defined inclusion and exclusion criteria. Eight papers were identified and included in this meta-analysis. The sample comprised a pooled total of 370 patients, of which 210 and 160 patients took PPIs and placebo, respectively. The difference between PPIs and placebo groups in overall improvement of symptoms in adult patients with LPR was not statistically significant (RR=1.22; 95%CI=0.93-1.58; P=0.149). The difference in cough improvement was also not significant between PPIs and placebo groups (RR=0.65; 95%CI=0.30-1.41; P=0.279).
DOI: 10.6084/m9.figshare.7899851.v1
title: Meta-analysis of the efficacy of proton pump inhibitors for the symptoms of laryngopharyngeal reflux

description: The objective of this study was to perform a systematic review and meta-analysis to assess the effectiveness of proton pump inhibitors (PPI) for reflux disease in adult patients with laryngopharyngeal symptoms. A comprehensive search of Cochrane Library, EMBASE, Ovid EBM Reviews, and PubMed was performed for English-language literature about laryngopharyngeal reflux (LPR), in September 2014. The papers were filtered using pre-defined inclusion and exclusion criteria. Eight papers were identified and included in this meta-analysis. The sample comprised a pooled total of 370 patients, of which 210 and 160 patients took PPIs and placebo, respectively. The difference between PPIs and placebo groups in overall improvement of symptoms in adult patients with LPR was not statistically significant (RR=1.22; 95%CI=0.93-1.58; P=0.149). The difference in cough improvement was also not significant between PPIs and placebo groups (RR=0.65; 95%CI=0.30-1.41; P=0.279).