cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.24155272.v1
title: Adverse event profile of CGRP monoclonal antibodies: findings from the FDA adverse event reporting database

description: Four CGRP Monoclonal Antibodies (mAbs) have been approved for migraine prophylaxis by the Food and Drug Administration (FDA) since 2018. However, there are concerns about the safety of these four drugs for real-world use. To compare the adverse event profiles of four CGRP-mAbs with FAERS data. The study was based on records from the FAERS database. Only reports containing one of the active ingredients with CGRP-mAbs were included in this study. Disproportionality analyses including but not limited to reporting odds ratio (ROR) and information components (IC) were conducted to identify drug-AE associations. In total, 58110 reports were identified for CGRP-mAbs. 80 overlapping signals were disproportionately reported. They affected a range of organs and systems, including the gastrointestinal and cardiovascular systems, skin, and hair. Additionally, the rare cardiovascular adverse events were significantly different among the four CGRP-mAbs. We identified numerous shared underlying signals (overlapping signals) for CGRP-mAbs as suspected drugs in multiple systems and organs. The unlabeled common signals may indicate potential safety issues. In addition, the underlying safety signals varied among the four CGRP-mAbs, particularly in the cardiovascular system, and further studies are needed to confirm these associations and the potential clinical implications.
DOI: 10.6084/m9.figshare.24815200
title: Comparative study on the occurrence of adverse effects in the concomitant use of azathioprine and aldehyde oxidase inhibitors

description: Aldehyde oxidase (AO) is a molybdenum-containing redox enzyme similar to xanthine oxidase that is involved in the thiopurine metabolism. This study investigated the effects of drug-drug interactions (DDIs) between azathioprine (AZA) and AO inhibitors on hematologic and hepatic disorders using the U.S. Food and Drug Administration Adverse Event Reporting System and the Japanese Adverse Drug Event Report database. The presence of DDI was assessed using the interaction signal scores (ISSs) calculated via the reporting odds ratios and 95% confidence intervals. The study used reports of ‘azathioprine’ as a suspect drug for adverse effects. AO inhibitors were selected based on previous <i>in</i> <i>vitro</i> reports. Some drugs tested positive for ISSs in each database and type of adverse effect (hematologic or hepatic disorder) analysis. Among these drugs, chlorpromazine, clozapine, hydralazine, and quetiapine could inhibit AZA metabolism via AO, given the previously reported clinical blood concentration and inhibitory effects of each drug. Concomitant use of AO inhibitors increased the signals for AZA-induced adverse effects. To date, no studies have evaluated the clinical importance of AO as a drug-metabolizing enzyme, and further <i>in</i> <i>vitro</i> and clinical research is needed to clarify the contribution of AO to the pharmacokinetics of thiopurines.
DOI: 10.6084/m9.figshare.24815200.v1
title: Comparative study on the occurrence of adverse effects in the concomitant use of azathioprine and aldehyde oxidase inhibitors

description: Aldehyde oxidase (AO) is a molybdenum-containing redox enzyme similar to xanthine oxidase that is involved in the thiopurine metabolism. This study investigated the effects of drug-drug interactions (DDIs) between azathioprine (AZA) and AO inhibitors on hematologic and hepatic disorders using the U.S. Food and Drug Administration Adverse Event Reporting System and the Japanese Adverse Drug Event Report database. The presence of DDI was assessed using the interaction signal scores (ISSs) calculated via the reporting odds ratios and 95% confidence intervals. The study used reports of ‘azathioprine’ as a suspect drug for adverse effects. AO inhibitors were selected based on previous <i>in</i> <i>vitro</i> reports. Some drugs tested positive for ISSs in each database and type of adverse effect (hematologic or hepatic disorder) analysis. Among these drugs, chlorpromazine, clozapine, hydralazine, and quetiapine could inhibit AZA metabolism via AO, given the previously reported clinical blood concentration and inhibitory effects of each drug. Concomitant use of AO inhibitors increased the signals for AZA-induced adverse effects. To date, no studies have evaluated the clinical importance of AO as a drug-metabolizing enzyme, and further <i>in</i> <i>vitro</i> and clinical research is needed to clarify the contribution of AO to the pharmacokinetics of thiopurines.
DOI: 10.6084/m9.figshare.14820872.v1
title: Additional file 2 of Zinc transporter SLC39A13/ZIP13 facilitates the metastasis of human ovarian cancer cells via activating Src/FAK signaling pathway

description: Additional file 2: Table S1. Clinical properties of the ovarian cancer patients used in the analysis. Table S2. Summary of the sequences of ZIP13 sgRNAs and primers for CRISPR. Table S3. Primers used in quantitative real-time RT-PCR. Table S4. The association of ZIP transporters with overall survival (OS) and progression-free survival (PFS) in patients with serous ovarian cancer. Table S5. Correlation of ZIP13 gene expression with survival in different clinical stages in ovarian cancer patients. Table S6. Correlation of ZIP13 gene expression with survival in different pathological grades in ovarian cancer patients. Table S7. KEGG pathway enrichment analysis of the ZIP13-regulated genes. Table S8. GO analysis of the biological processes associated with ZIP13-regulated genes. Table S9. GO analysis of the molecular functions associated with ZIP13-regulated genes. Table S10. KEGG pathway enrichment analysis of the ZIP13-regulated genes in ovarian cancer patients from TCGA.
DOI: 10.24403/jp.1328716
title: Perspectives on „Monographie der Gattung Epilobium“ of Carl Haussknecht / Peter C. Hoch und Peter H. Raven
DOI: 10.24403/jp.1328724
title: Zur Kenntnis von Galium schultesii VEST in Thüringen und Franken / Karl Peter Buttler und Ludwig Meinunger
DOI: 10.6084/m9.figshare.14820908.v1
title: Additional file 3 of Limited recurrence distance of glioblastoma under modern radiotherapy era

description: Additional file 3.
DOI: 10.6084/m9.figshare.14820929
title: Additional file 2 of Effectiveness of digital interventions to improve household and community infection prevention and control behaviours and to reduce incidence of respiratory and/or gastro-intestinal infections: a rapid systematic review

description: Additional file 2. List of articles excluded after full-text screening. List of excluded English and Chinese studies. List includes reasons identified for exclusion of the studies.
DOI: 10.6084/m9.figshare.14820929.v1
title: Additional file 2 of Effectiveness of digital interventions to improve household and community infection prevention and control behaviours and to reduce incidence of respiratory and/or gastro-intestinal infections: a rapid systematic review

description: Additional file 2. List of articles excluded after full-text screening. List of excluded English and Chinese studies. List includes reasons identified for exclusion of the studies.
DOI: 10.6084/m9.figshare.14820892.v1
title: Additional file 1 of TeaAS: a comprehensive database for alternative splicing in tea plants (Camellia sinensis)

description: Additional file 1: Table S1. Details of 66 RNA-seq dataset.
DOI: 10.6084/m9.figshare.14820872
title: Additional file 2 of Zinc transporter SLC39A13/ZIP13 facilitates the metastasis of human ovarian cancer cells via activating Src/FAK signaling pathway

description: Additional file 2: Table S1. Clinical properties of the ovarian cancer patients used in the analysis. Table S2. Summary of the sequences of ZIP13 sgRNAs and primers for CRISPR. Table S3. Primers used in quantitative real-time RT-PCR. Table S4. The association of ZIP transporters with overall survival (OS) and progression-free survival (PFS) in patients with serous ovarian cancer. Table S5. Correlation of ZIP13 gene expression with survival in different clinical stages in ovarian cancer patients. Table S6. Correlation of ZIP13 gene expression with survival in different pathological grades in ovarian cancer patients. Table S7. KEGG pathway enrichment analysis of the ZIP13-regulated genes. Table S8. GO analysis of the biological processes associated with ZIP13-regulated genes. Table S9. GO analysis of the molecular functions associated with ZIP13-regulated genes. Table S10. KEGG pathway enrichment analysis of the ZIP13-regulated genes in ovarian cancer patients from TCGA.
DOI: 10.6084/m9.figshare.14820901
title: Additional file 4 of TeaAS: a comprehensive database for alternative splicing in tea plants (Camellia sinensis)

description: Additional file 4: Table S3. Information of differentially expressed AS by rMATS analysis.
DOI: 10.6084/m9.figshare.13245826.v1
title: Additional file 1 of A phenome-wide association study of ABO blood groups

description: Additional file 1: Table S1. ABO blood group antigens and corresponding tag SNPs. Table S2. The associations of four tag SNPs for ABO blood group antigens with 3873 phenotypes. Table S3. The number of binary phenotypes and characteristics of their cases by disease category. Table S4. The number of continuous and categorical ordered phenotypes included and characteristics of their sample sizes in each category. Table S5. Comparison between study results and replication results.
DOI: 10.6084/m9.figshare.13245895
title: Additional file 10 of A comprehensive analysis of cotton VQ gene superfamily reveals their potential and extensive roles in regulating cotton abiotic stress

description: Additional file 10: Table S5. List of predicted known microRNA target sites of VQ transcripts in Gossypium species.
DOI: 10.6084/m9.figshare.13245913
title: Additional file 1 of A comprehensive analysis of cotton VQ gene superfamily reveals their potential and extensive roles in regulating cotton abiotic stress

description: Additional file 1: Table S1. Summaries of VQ genes members in Gossypium.
DOI: 10.6084/m9.figshare.13245904.v1
title: Additional file 13 of A comprehensive analysis of cotton VQ gene superfamily reveals their potential and extensive roles in regulating cotton abiotic stress

description: Additional file 13: Table S6. Expression levels of GhVQs and GbVQs. The gene expression was determined by RNA-Seq data (FPKM).
DOI: 10.6084/m9.figshare.13245907
title: Additional file 14 of A comprehensive analysis of cotton VQ gene superfamily reveals their potential and extensive roles in regulating cotton abiotic stress

description: Additional file 14: Table S7. Information regarding the Co-expression and STRING search results of the interaction networks of the GhVQs.
DOI: 10.6084/m9.figshare.14820910
title: Additional file 1 of Transcriptome analysis reveals Vernalization is independent of cold acclimation in Arabidopsis

description: Additional file 1: Table S1. DEGs in cluster 1, 2, 3, 4, 5, 6, 7, 8, 9.
DOI: 10.6084/m9.figshare.14820910.v1
title: Additional file 1 of Transcriptome analysis reveals Vernalization is independent of cold acclimation in Arabidopsis

description: Additional file 1: Table S1. DEGs in cluster 1, 2, 3, 4, 5, 6, 7, 8, 9.
DOI: 10.6084/m9.figshare.14820922
title: Additional file 5 of Transcriptome analysis reveals Vernalization is independent of cold acclimation in Arabidopsis

description: Additional file 5: Table S5. DEGs regulated by alternative splicing mechanism and CAMTA3, MPK3, MPK6 and OST1.
DOI: 10.6084/m9.figshare.14820916
title: Additional file 3 of Transcriptome analysis reveals Vernalization is independent of cold acclimation in Arabidopsis

description: Additional file 3: Table S3. Information of DEGs in weighted gene co-expression network analysis.
DOI: 10.6084/m9.figshare.14820913
title: Additional file 2 of Transcriptome analysis reveals Vernalization is independent of cold acclimation in Arabidopsis

description: Additional file 2: Table S2. DEGs in cold stress and vernalization pathways.
DOI: 10.6084/m9.figshare.14820925.v1
title: Additional file 6 of Transcriptome analysis reveals Vernalization is independent of cold acclimation in Arabidopsis

description: Additional file 6: Table S6. Oligous used as primers in the experiment.
DOI: 10.6084/m9.figshare.14820913.v1
title: Additional file 2 of Transcriptome analysis reveals Vernalization is independent of cold acclimation in Arabidopsis

description: Additional file 2: Table S2. DEGs in cold stress and vernalization pathways.
DOI: 10.15156/bio/sh1127887.09fu
title: SH1127887.09FU

description: UNITE provides a unified way for delimiting, identifying, communicating, and working with DNA-based Species Hypotheses (SH). All fungal ITS sequences in the international nucleotide sequence databases are clustered to approximately the species level by applying a set of dynamic distance values (<0.5 - 3.0%). All species hypotheses are given a unique, stable name in the form of a DOI, and their taxonomic and ecological annotations are verified through distributed, web-based third-party annotation efforts. SHs are connected to a taxon name and its classification as far as possible (phylum, class, order, etc.) by taking into account identifications for all sequences in the SH. An automatically or manually designated sequence is chosen to represent each such SH. These sequences are released (https://unite.ut.ee/repository.php) for use by the scientific community in, for example, local sequence similarity searches and next-generation sequencing analysis pipelines. The system and the data are updated automatically as the number of public fungal ITS sequences grows.
DOI: 10.15156/bio/sh1127888.09fu
title: SH1127888.09FU

description: UNITE provides a unified way for delimiting, identifying, communicating, and working with DNA-based Species Hypotheses (SH). All fungal ITS sequences in the international nucleotide sequence databases are clustered to approximately the species level by applying a set of dynamic distance values (<0.5 - 3.0%). All species hypotheses are given a unique, stable name in the form of a DOI, and their taxonomic and ecological annotations are verified through distributed, web-based third-party annotation efforts. SHs are connected to a taxon name and its classification as far as possible (phylum, class, order, etc.) by taking into account identifications for all sequences in the SH. An automatically or manually designated sequence is chosen to represent each such SH. These sequences are released (https://unite.ut.ee/repository.php) for use by the scientific community in, for example, local sequence similarity searches and next-generation sequencing analysis pipelines. The system and the data are updated automatically as the number of public fungal ITS sequences grows.
DOI: 10.15156/bio/sh1127889.09fu
title: SH1127889.09FU

description: UNITE provides a unified way for delimiting, identifying, communicating, and working with DNA-based Species Hypotheses (SH). All fungal ITS sequences in the international nucleotide sequence databases are clustered to approximately the species level by applying a set of dynamic distance values (<0.5 - 3.0%). All species hypotheses are given a unique, stable name in the form of a DOI, and their taxonomic and ecological annotations are verified through distributed, web-based third-party annotation efforts. SHs are connected to a taxon name and its classification as far as possible (phylum, class, order, etc.) by taking into account identifications for all sequences in the SH. An automatically or manually designated sequence is chosen to represent each such SH. These sequences are released (https://unite.ut.ee/repository.php) for use by the scientific community in, for example, local sequence similarity searches and next-generation sequencing analysis pipelines. The system and the data are updated automatically as the number of public fungal ITS sequences grows.
DOI: 10.15156/bio/sh1127890.09fu
title: SH1127890.09FU

description: UNITE provides a unified way for delimiting, identifying, communicating, and working with DNA-based Species Hypotheses (SH). All fungal ITS sequences in the international nucleotide sequence databases are clustered to approximately the species level by applying a set of dynamic distance values (<0.5 - 3.0%). All species hypotheses are given a unique, stable name in the form of a DOI, and their taxonomic and ecological annotations are verified through distributed, web-based third-party annotation efforts. SHs are connected to a taxon name and its classification as far as possible (phylum, class, order, etc.) by taking into account identifications for all sequences in the SH. An automatically or manually designated sequence is chosen to represent each such SH. These sequences are released (https://unite.ut.ee/repository.php) for use by the scientific community in, for example, local sequence similarity searches and next-generation sequencing analysis pipelines. The system and the data are updated automatically as the number of public fungal ITS sequences grows.
DOI: 10.15156/bio/sh1127891.09fu
title: SH1127891.09FU

description: UNITE provides a unified way for delimiting, identifying, communicating, and working with DNA-based Species Hypotheses (SH). All fungal ITS sequences in the international nucleotide sequence databases are clustered to approximately the species level by applying a set of dynamic distance values (<0.5 - 3.0%). All species hypotheses are given a unique, stable name in the form of a DOI, and their taxonomic and ecological annotations are verified through distributed, web-based third-party annotation efforts. SHs are connected to a taxon name and its classification as far as possible (phylum, class, order, etc.) by taking into account identifications for all sequences in the SH. An automatically or manually designated sequence is chosen to represent each such SH. These sequences are released (https://unite.ut.ee/repository.php) for use by the scientific community in, for example, local sequence similarity searches and next-generation sequencing analysis pipelines. The system and the data are updated automatically as the number of public fungal ITS sequences grows.
DOI: 10.15156/bio/sh1127892.09fu
title: SH1127892.09FU

description: UNITE provides a unified way for delimiting, identifying, communicating, and working with DNA-based Species Hypotheses (SH). All fungal ITS sequences in the international nucleotide sequence databases are clustered to approximately the species level by applying a set of dynamic distance values (<0.5 - 3.0%). All species hypotheses are given a unique, stable name in the form of a DOI, and their taxonomic and ecological annotations are verified through distributed, web-based third-party annotation efforts. SHs are connected to a taxon name and its classification as far as possible (phylum, class, order, etc.) by taking into account identifications for all sequences in the SH. An automatically or manually designated sequence is chosen to represent each such SH. These sequences are released (https://unite.ut.ee/repository.php) for use by the scientific community in, for example, local sequence similarity searches and next-generation sequencing analysis pipelines. The system and the data are updated automatically as the number of public fungal ITS sequences grows.
DOI: 10.15156/bio/sh1127893.09fu
title: SH1127893.09FU

description: UNITE provides a unified way for delimiting, identifying, communicating, and working with DNA-based Species Hypotheses (SH). All fungal ITS sequences in the international nucleotide sequence databases are clustered to approximately the species level by applying a set of dynamic distance values (<0.5 - 3.0%). All species hypotheses are given a unique, stable name in the form of a DOI, and their taxonomic and ecological annotations are verified through distributed, web-based third-party annotation efforts. SHs are connected to a taxon name and its classification as far as possible (phylum, class, order, etc.) by taking into account identifications for all sequences in the SH. An automatically or manually designated sequence is chosen to represent each such SH. These sequences are released (https://unite.ut.ee/repository.php) for use by the scientific community in, for example, local sequence similarity searches and next-generation sequencing analysis pipelines. The system and the data are updated automatically as the number of public fungal ITS sequences grows.
DOI: 10.15156/bio/sh1127894.09fu
title: SH1127894.09FU

description: UNITE provides a unified way for delimiting, identifying, communicating, and working with DNA-based Species Hypotheses (SH). All fungal ITS sequences in the international nucleotide sequence databases are clustered to approximately the species level by applying a set of dynamic distance values (<0.5 - 3.0%). All species hypotheses are given a unique, stable name in the form of a DOI, and their taxonomic and ecological annotations are verified through distributed, web-based third-party annotation efforts. SHs are connected to a taxon name and its classification as far as possible (phylum, class, order, etc.) by taking into account identifications for all sequences in the SH. An automatically or manually designated sequence is chosen to represent each such SH. These sequences are released (https://unite.ut.ee/repository.php) for use by the scientific community in, for example, local sequence similarity searches and next-generation sequencing analysis pipelines. The system and the data are updated automatically as the number of public fungal ITS sequences grows.
DOI: 10.15156/bio/sh1127895.09fu
title: SH1127895.09FU

description: UNITE provides a unified way for delimiting, identifying, communicating, and working with DNA-based Species Hypotheses (SH). All fungal ITS sequences in the international nucleotide sequence databases are clustered to approximately the species level by applying a set of dynamic distance values (<0.5 - 3.0%). All species hypotheses are given a unique, stable name in the form of a DOI, and their taxonomic and ecological annotations are verified through distributed, web-based third-party annotation efforts. SHs are connected to a taxon name and its classification as far as possible (phylum, class, order, etc.) by taking into account identifications for all sequences in the SH. An automatically or manually designated sequence is chosen to represent each such SH. These sequences are released (https://unite.ut.ee/repository.php) for use by the scientific community in, for example, local sequence similarity searches and next-generation sequencing analysis pipelines. The system and the data are updated automatically as the number of public fungal ITS sequences grows.
DOI: 10.15156/bio/sh1127896.09fu
title: SH1127896.09FU

description: UNITE provides a unified way for delimiting, identifying, communicating, and working with DNA-based Species Hypotheses (SH). All fungal ITS sequences in the international nucleotide sequence databases are clustered to approximately the species level by applying a set of dynamic distance values (<0.5 - 3.0%). All species hypotheses are given a unique, stable name in the form of a DOI, and their taxonomic and ecological annotations are verified through distributed, web-based third-party annotation efforts. SHs are connected to a taxon name and its classification as far as possible (phylum, class, order, etc.) by taking into account identifications for all sequences in the SH. An automatically or manually designated sequence is chosen to represent each such SH. These sequences are released (https://unite.ut.ee/repository.php) for use by the scientific community in, for example, local sequence similarity searches and next-generation sequencing analysis pipelines. The system and the data are updated automatically as the number of public fungal ITS sequences grows.