cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.21966848
title: mast cell quantification raw data.xlsx

description: raw data of a retrospective study done on hypoplastic bone marrows. Quantification of mast cell is done in hypoplastic bone marrow trephine biopsies to differentiate between aplastic anemia and hypoplastic myelodysplastic neoplasm. Presence of increased number of mast cells has been correlated with decreased number of hematopoietuc stem cells. File: rawdata.xlxs this file provides the excel sheet of the collected raw data of all the cases included in the study. key to excel sheet 0: Absent; 1: Present; NA: Not available; D: Decreased, I: Increased; &lt;: Less than; &gt;: More than <br> File: <strong>STROBE_checklist. Mast cell</strong> quantification.xlxs the study follows the guidelines of STROBE for observational studies. the checklist is uploded in this file. <br> File 1.jpg,2.jpg,3.jpg,4.jpg,5.jpg and 6.jpg these files are the original, uncropped, unedited, unannotated and unprocessed microphotographs of the bone marrow biopsy slides under light microscopy. <br> 1.jpg : apalstic anemia, magnification 4X, hematoxylin and eosin staining 2.jpg: metachromatically stained mast cells, magnification 10X, Toluidine Blue staining 3.jpg: metachromatically stained mast cells, magnification 20X, Toluidine Blue staining 4.jpg: metachromatically stained mast cells, magnification 40X, Toluidine Blue staining 5.jpg : MDS-h, hypoplastic marrow, magnification 4X, hematoxylin and eosin staining 6.jpg: metachromatically stained mast cells, magnification 40X, Toluidine Blue staining <br> File: procedure of CD34 IHC staining this file provides the step by step procedure for CD34 IHC satining including te reagents used and time frames. <br>
DOI: 10.6084/m9.figshare.25027082.v1
title: Risk of Bias-Favipiravir for covid-19

description: Favipiravir for covid-19
DOI: 10.6084/m9.figshare.25620519
title: Small mammal visits to TRASH-Cams

description: Describes the number of visits (foraging bouts) made by small mammals to seed removal stations in a temperate deciduous forest (Hamilton College Experimental Forest.Common variables:<br>Collection.date: describes the month data were collected (0 = October, 2 = December, 3 = January, 6 = April)<br>Site: Categorical variable for plot (14 levels)Species: Categorical variable describing the identity of three species of small mammals (Peromyscus spp., Tamiasciurus hudsonicus, Tamias striatus)<br>Visit data variables:<br>Visit.count: Numerical data describing the number of visits by each speciesID: A unique row ID to account for overdispersion in dataCamera data variables:<br>Tray: Unique ID for seed depotVideo.number: A unique numerical id for each video<br>Date: Date video was recordedTemperature: Air temperature at time of video recording<br>Time.start: The time at which a video started (24 hour clock)Video.length: Length of video in seconds<br>Lonicera.eaten: Number of Lonicera spp. seeds eaten during the visit
DOI: 10.6084/m9.figshare.26537998
title: Hourly-level ozone concentration retrieved by GEMS and relative analysis on model accuracy and environmental implications

description: Due to the large volume of the satellite datasets, this repository would provide the minimum dataset, which contains the processed hourly-level ozone concentrations (demo) and yearly-level analysis results. The codes to process the hourly-level ozone concentration to analyze and validate the figures in the paper are deposited in the Github
with DOI of 10.5281/zenodo.14947640.
DOI: 10.6084/m9.figshare.28691093
title: Data and code for Kaya et al. (2025)

description: Data and code for Kaya et al (2025)
DOI: 10.6084/m9.figshare.28777943
title: Supplementary Material for: Brain metastases of a triple-negative breast cancer – A systematic literature review of the systemic treatment options

description: Background: The development of brain metastases (BM) is an increasing concern for patients with metastatic triple-negative breast cancer (mTNBC). This systematic review aims to summarize the current evidence regarding systemic treatment options for patients with mTNBC and BM. 
Methods: A systematic literature review was conducted by searching the database 
PubMed with the key words „metastatic triple-negative breast cancer“, ”therapy“ and “brain metastases”. Articles were screened and included if they focused on the treatment of mTNBC. Both prospective and retrospective clinical trials were eligible for inclusion. 
Results:The literature search identified 3,413 articles, of which eight met the inclusion criteria. These studies provided evidence for the treatment of patients with stable BM using Sacituzumab Govitecan (SG), Pembrolizumab combined with chemotherapy, Trastuzumab Deruxtecan (T-DXd), Nab-paclitaxel combined with Cisplatin, and Talazoparib. 
No evidence was found for active BM or leptomeningeal metastases. 
Conclusion: Based on the current evidence discussed in this review, testing for PD-L1, HER2, including immunohistochemistry (IHC) status as well as germline BRCA 1/2 mutation should be considered in all mTNBC patients with BM as the results have significant treatment implications.. Moreover, PD-L1 expression should be evaluated on primary tumor and (if tissue sample available) reevaluated on BMs if negative on primary BC, to maximize the opportunity for treatment with immune checkpoint inhibitors (ICI). Furthemore, if brain tissue available HER2 IHC should also be tested in order to evaluate the status switch and to assess the therapeutic effectiveness of treatment with T-DXd. 
Further targeted agents are urgently needed in order to improve the survival of patients with TNBC and BM
DOI: 10.6084/m9.figshare.28777949
title: Supplementary Material for: Exploring Kidney Injury Molecule-1 and HAVCR1 Polymorphisms as Predictive Biomarkers in Chronic Kidney Disease

description: Introduction
Kidney Injury Molecule-1 (KIM-1), encoded by the Hepatitis A Virus Cellular Receptor 1 (HAVCR1) gene, plays a crucial role in kidney injury progression. Although serum and urinary KIM-1 levels are established biomarkers for kidney damage, the relationship between KIM-1 levels, HAVCR1 gene polymorphism, and chronic kidney disease (CKD) stages remains unclear. This study aimed to investigate KIM-1 as a potential biomarker for CKD progression in the Thai population and explore its association with genetic polymorphisms in the HAVCR1 gene.
Methods
A total of 250 patients with CKD were recruited from Khon Kaen, Thailand. Serum and urinary KIM-1 levels were measured using an indirect enzyme-linked immunosorbent assay. Single-nucleotide polymorphism (SNP) genotyping was conducted using the TaqMan assay to assess the associations between KIM-1 levels, SNPs, and CKD progression. Statistical analyses were conducted to assess the correlations between estimated glomerular filtration rate (eGFR), KIM-1 levels, and SNPs.
Results
Serum and urinary KIM-1 levels showed a significant negative correlation with eGFR, indicating higher KIM-1 levels in patients with more advanced CKD. However, the rs6555820 SNP in the HAVCR1 gene did not show a significant association with KIM-1 levels or eGFR. Interestingly, a significant association between rs6555820 and gender was observed, implying a potential gender-dependent genetic impact.
Conclusion
Serum and urinary KIM-1 levels have been found to be associated with CKD stages and eGFR, suggesting their potential as biomarkers for assessing CKD severity. However, no direct associations were observed between the SNP rs6555820 and KIM-1 levels or eGFR. Further research is required to elucidate the genetic mechanisms underlying CKD progression.
DOI: 10.6084/m9.figshare.28782386
title: Supplementary Material for: The Association of Cumulative Chinese Visceral Adiposity Index and New-Onset Hypertension in Middle-Aged and Elderly Chinese Populations: A cohort study

description: Introduction: Previous studies have reported a significant relationship between the baseline Chinese visceral adipose index (CVAI) and the risk of new-onset hypertension (NOH). However, the long-term effect of the CVAI and the risk of NOH remains uncertain. This study aimed to investigate the association between the cumulative CVAI and the risk of NOH.

Methods: Data were obtained from the China Health and Retirement Longitudinal Study from 2011 to 2020. In total, of 2836 Chinese participants ≥45 years were included. Multivariable logistic regression analysis as well as restricted cubic spline regression analysis were performed to assess the association of the cumulative CVAI, visceral adiposity index (VAI), and lipid accumulation product (LAP) with the risk of NOH. Furthermore, receiver operating characteristic (ROC) curve analysis was used to determine the area under the ROC curves between the risk of NOH and the adiposity indices to compare the predictive powers of the cumulative CVAI, VAI, and LAP for NOH.

Results: During the 5-year follow-up period, 433 cases of NOH were recorded. The cumulative CVAI, VAI, and LAP were positively associated with the risk of NOH. After adjusting for potential confounders, as compared to the lowest quartile of the cumulative CVAI, VAI, and LAP, the participants in the highest quartile had a significantly higher risk for NOH (odds ratio = 1.74, 1.46, and 1.95; 95% confidence interval = 1.25–2.42, 1.05–2.03, and 1.39–2.75, respectively). ROC analysis revealed that the cumulative CVAI had the highest relationship with the risk of NOH.

Conclusion: The cumulative CVAI was positively associated with an increased risk of NOH in middle-aged and elderly Chinese populations. In addition, the performance of the cumulative CVAI to predict NOH was superior to other visceral obesity indices. Monitoring long-term changes to the CVAI may assist with early identification of individuals at high risk of NOH.
DOI: 10.6084/m9.figshare.28787243
title: Supplementary Material for: Global, regional, and national burden of leukemia, 1990–2021: a systematic analysis for the global burden of disease study 2021

description: Background: Leukemia is a group of diseases caused by malignant hematopoietic stem cell clones. Leukemia ranks 13th in incidence and 10th in mortality, according to the Global Cancer Statistics 2022. 
Method: We computed the prevalence, incidence, mortality, and disability-adjusted life years (DALYs) using the Global Burden of Disease (GBD) 2021 data. We rigorously tested the time trend from 1990 to 2021 using Joinpoint regression analysis. This method facilitates the calculation of annual percentage change (APC), average annual percentage change (AAPC), and 95% confidence interval (CI). 
Results: In 2021, the age-standardized prevalence rate (ASPR), age-standardized incidence rate (ASIR), age-standardized mortality rate (ASMR), and age-standardized DALYs rate of leukemia were 21.07 per 100,000 people (95% CI:17.65-23.61), 5.63 per 100,000 people (95% CI: 4.83-6.17), 3.89 per 100,000 people (95% CI:3.34-4.25), and 136.94 per 100,000 people (95% CI:111.89-153.71), respectively. These figures have been obtained globally. Gender comparisons show that men have a higher burden of disease.The 90-94 age group has the highest global prevalence of leukemia, with the prevalence increasing with age. Age-standardized DALYs rates, ASMR, and ASIR demonstrated a general declining trend from 1990 to 2021. The results of the Joinpoint analysis showed that between 2019 and 2021, there was a drop in the global ASPR (APC=-2.68%; 95% CI:-4.76% to -0.54%; P=0.017), ASIR (APC=-2.46%; 95% CI:-3.33% to -1.59%; P&lt;0.001), and ASMR (APC=-1.87%; 95% CI: -2.75% to -0.99%; P&lt;0.001).
Conclusion: The results indicated an overall decrease in the burden of leukemia. These results provide important epidemiological data for the development of novel treatments.
DOI: 10.6084/m9.figshare.28787249
title: Supplementary Material for: Tolerance evaluation of non-steroidal anti-inflammatory drug hypersensitivity in children: Is age the crucial factor?

description: Introduction: Little is known about the natural history of pediatric nonsteroidal anti-inflammatory drug hypersensitivity (NSAID-H). The aim of this prospective study was to evaluate tolerance development in pediatric patients with confirmed, immediate NSAID-H and to determine the risk factors for NSAID-H persistence.
Methods: Children with a confirmed diagnosis of NSAID-H were assessed for tolerance by drug provocation test (DPT) at least three years after diagnosis. Factors associated with developing tolerance in NSAID-H were investigated.
Results: Of the 34 cases with confirmed NSAID-H diagnosis, 23 (67.65%) were included. The median (range) age at the last DPT was 16.5 (13.2-20.4) years. Tolerance developed in 12 (52.1%) of the 23 patients evaluated. Survival analysis showed that median duration to develop tolerance was 6.16 years from the initial reaction (SE=18.6). ROC analysis gave a cut-off value for initial reaction age as ≤11.75 years in predicting NSAID-H tolerance with specificity 83.3%, sensitivity 81.8%, (AUC=0.830, 95%CI 0.616-0.952, p&lt;0.001). Univariate logistic regression analysis showed that the risk of persistence of NSAID-H was 1.3-fold higher with each additional year from the initial reaction [1/Odds Ratio(OR)] (OR=0.754, 95%CI 0.964-0.590; p=0.024). At the diagnostic DPT, in the tolerant group, urticaria (42.7%) was more common (p=0.006) and the persistent group reacted at a significantly lower cumulative dose (p=0.044).
Conclusion: Half of the patients with NSAID-H developed tolerance, around six years after the initial reaction. The probability of tolerance rises if the initial reaction occurs before the age of 11.75 years and if urticaria was observed at presentation. Reaction at low doses on diagnostic DPT may be a predictor of persistence.
DOI: 10.6084/m9.figshare.28787252
title: Supplementary Material for: Primary Vitreoretinal Lymphomas: A Diagnostic Challenge. Report of two recent cases with retinal biopsies and molecular investigations in Halifax, Nova Scotia.

description: Introduction
Primary vitreoretinal lymphomas (PVRL) are a type of central nervous system lymphoma that arise in the retina, vitreous, or optic nerve without initial brain involvement. The clinical diagnosis can be a challenge since the disease mimics uveoretinitis in its presentation and initial treatment response to steroids. Diagnostic confirmation with vitreous cytology has been the gold standard for diagnosis. However, there are limitations of vitreous cytology such as low volume of sample, low number of lymphoma cells within the sample, and poor preservation of cells due to shearing forces of vitrectomy. There has been a long-standing need for alternative options to improve the diagnostic yield of PVRLs. Recently, MYD88 gene mutations (myeloid differentiation response gene 88) have been found in 69-82.4% of PVRLs.
Case Presentations
Case 1: 89-year-old male with a retinal detachment post cataract surgery. He had subsequent surgical repair but continued to have poor and worsening vision and developed constitutional symptoms including weight loss and decreased appetite. A vitreous sample submitted for molecular studies, demonstrated MYD88 L265P mutation and a retinal biopsy showed large B lymphocytes infiltrating the retina. 
Case 2: 62-year-old female referred to the Uveitis Clinic for assessment of chronic right eye panuveitis and left eye anterior uveitis. The patient developed symptoms (blurry vision and photophobia) 9 months prior to the referral. A vitreous biopsy was conducted and was negative for MYD88 mutations and large B cells were not seen on vitreous cytology. The fundus view post-vitrectomy revealed an area of necrotizing retinitis. The patient was started on empiric treatment for herpetic and parasitic etiologies and on high dose oral prednisone shortly after. She had a further decline in her right eye vision with significant extension of the necrotizing retinitis into the macula and optic disc. A retinal biopsy then revealed atypical large B-cells infiltrating the retina.
Conclusion
PVRLs are rare and establishing the diagnosis is difficult. The traditional use of vitreous cytology has its limitations. Recent molecular advances, in particular the detection of MYD88 mutation is extremely helpful to confirm the diagnosis, but in certain cases retinal biopsies may still be required.
DOI: 10.6084/m9.figshare.28787255
title: Supplementary Material for: The moderating effect of tobacco smoking on the efficacy of a computer-based brief alcohol intervention: Results from a randomized controlled trial

description: Objective: Alcohol consumption and tobacco smoking may have synergistic harmful effects when present in combination. This combination is highly prevalent and associated with a multitude of diseases. Brief alcohol intervention (BAI) may be less effective among persons who drink alcohol and smoke tobacco than among persons who drink alcohol and do not smoke. The aim of this study was to find out whether BAI is more effective among adults who do not smoke than among those who smoke.
Methods: This study reports secondary outcome analyses of the randomized controlled trial “Testing a proactive expert system intervention to prevent and to quit at-risk alcohol use”. Among municipal office clients, 1646 who were aged 18-64 and consumed alcohol in the last year participated. Using latent growth curve models the impact of BAI was compared by incidence rate ratios (IRRs) of self-reported heavy drinking days and the moderating effect of smoking was investigated.
Results: There was no significant difference between intervention and control in reducing heavy drinking days in persons who never smoked (IRR 1.01, 95% Confidence Interval (CI) 0.92-1.10, P = 0.847), formerly smoked (IRR 0.91, CI 0.77-1.07, P = 0.234), currently smoked less than daily (IRR 0.98, CI 0.86-1.12, P = 0.782) and persons who currently smoked daily (IRR 1.09, CI 0.98-1.22, P = 0.125). 
Conclusion: The effect of BAI did not differ among study participants who currently smoked as among participants who did not. Although not statistically significant, persons who formerly smoked tended to benefit. Persons who currently smoked did not benefit.
DOI: 10.6084/m9.figshare.28787258
title: Supplementary Material for: Living donor liver transplantation for neo-adjuvant treated, unresectable intrahepatic cholangiocarcinoma (LIVINCA): study protocol for a one-armed, mono-centric, non-randomized trial

description: Background
Intrahepatic cholangiocarcinoma has demonstrated a consistently increasing incidence in recent years. In cases of unresectability, palliative chemotherapy often remains the only option, typically associated with a poor prognosis. Liver transplantation might be an option for otherwise unresectable intrahepatic cholangiocarcinoma. We aim to conduct a prospective, non-randomized study to further explore the effects of living-donor liver transplantation in the treatment of unresectable neoadjuvant treated intrahepatic cholangiocarcinoma.

Methods
Patients with unresectable intrahepatic cholangiocarcinoma having a stable disease or tumor regression after systemic chemotherapy without an extrahepatic tumor burden are suitable for study inclusion. For a local control of the tumor, an additional local-ablative therapy in means of a selective internal radio-therapy is mandatory. 
The main concept of the surgical procedure is a liver transplantation using the left (segments II – IV) or the right lobe (segments V – VIII) of a living donor. In oncosurgical optimal conditions, a two-staged hepatectomy combined with the (initially) auxiliary transplantation of a left-lateral lobe of a living donor is the possible. 

Results
The patient recruitment will start in September 2024.

Conclusion
The design of the LIVINCA study may provide patients with otherwise unresectable intrahepatic cholangiocarcinoma a chance for a curative treatment option. This procedure does not reduce the deceased donor organ supply because living donation is the primary treatment option in these patients.

Trial registration
Registered at Clinical Trials; NCT06539377; registered on August 6, 2024.
DOI: 10.7265/skbg-kf16
title: Circum-Arctic Map of Permafrost and Ground-Ice Conditions, Version 2
DOI: 10.7939/dvn/ejue1g
title: Diamond Inclusion Database

description: Database of major element compositions of mineral inclusions in diamond, combined with physical, IR-spectroscopic and stable isotopic characteristics of their host diamonds
DOI: 10.7946/p2g596
title: Improved kabuli reference genome
DOI: 10.7946/p2kw2q
title: Improved desi reference genome
DOI: 10.17632/rvt89578g5.1
title: Swahili Verb Conjugation Dataset: A Comprehensive Analysis of Agglutination and Verb Structure Across Tenses and Persons

description: This Swahili Verb Conjugation Dataset offers a rich and detailed collection of over 319,156 conjugated verb forms, meticulously compiled to capture the complexity of Swahili’s agglutinative verb morphology. Swahili is known for its rich inflectional system, where verbs are modified by adding prefixes and suffixes to encode grammatical information such as tense, aspect, person, number, and mood.

The dataset consists of a single CSV file, where each row represents a unique verb root (mzizi_wa_neno) and its conjugated forms across multiple dimensions:

Tenses: The dataset captures five core tenses: past, perfect, present, future, and simple present. These tenses play a critical role in Swahili verb conjugation and vary significantly from English tense structures, making this dataset an essential resource for handling these tense markers in NLP tasks.
Persons and Numbers: Conjugations are provided for the 1st, 2nd, and 3rd persons, both singular (umoja) and plural (wingi). Each of these persons is conjugated across the five tenses, providing a comprehensive overview of the morphological changes that occur depending on the subject.
Moods: The dataset includes the habitual mood (hali_ya_mazoea), as well as other modal forms and auxiliary verbs that are part of Swahili’s verb system, such as kum (ability), kuwa (to be), and various hypothetical forms (e.g., ninge, unge, ange for conditional tense).
The columns in the dataset include:

Verb Root (mzizi_wa_neno): The base form of the verb from which all conjugated forms are derived.
Conjugated Forms: These columns represent the verb conjugations for the 1st, 2nd, and 3rd persons, both singular and plural, across all tenses. For example, nafsi_ya_kwanza_umoja_wakati_uliopita refers to the 1st person singular in the past tense.
This dataset not only provides standard conjugations for Swahili verbs but also covers various auxiliary and hypothetical forms. The extensive collection of forms makes this dataset an invaluable resource for researchers interested in Swahili Natural Language Processing (NLP), as it offers the morphological richness needed for tasks like tokenization, lemmatization, and syntactic parsing.

Additionally, this dataset is adaptable for linguistic research beyond computational applications. It can be used to study Swahili verb morphology, tense-aspect systems, and cross-linguistic comparisons with other agglutinative languages.
DOI: 10.17909/8by2-x206
title: Data from ERS 1386 AMI papers Ray et al. and Sallum et al.