cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.22730336
title: Personal protective equipment simulation training is associated with lower COVID-19 infection among healthcare workers

description: ABSTRACT Objective To describe the personal protective equipment training strategies during the beginning of the pandemic and to investigate the association between training and COVID-19 infection among healthcare workers. Methods This cross-sectional study conducted between March and May 2020 included 7,142 healthcare professionals who were eligible for both online and face-to-face simulation-based training on personal protective equipment use. Simulation training attendance was assessed by reviewing the attendance list, and the COVID-19 sick leave records recovered from the institutional RT-PCR database used to grant sick leave. The association between personal protective equipment training and COVID-19 was investigated using logistic regression, adjusted for sociodemographic and occupational characteristics. Results The mean age was 36.9 years (± 8.3), and 72.6% of participants were female. A total of 5,502 (77.0%) professionals were trained: 3,012 (54.7%) through online training, 691 (12.6%) through face-to-face training, and 1,799 (32.7%) through both strategies. During the study period, 584 (8.2%) COVID-19 cases were diagnosed among these professionals. The number of positive RT-PCR tests was 180 (11.0%) for untrained professionals, 245 (8.1%) for those trained only online, 35 (5.1%) for those trained face-to-face, and 124 (6.9%) for those trained with both strategies (p&lt;0.001). Participants who received face-to-face training had a 0.43 lower risk of contracting COVID-19. Conclusion Personal protective equipment training decreased the odds of COVID-19 among healthcare professionals, with face-to-face simulation-based training being most effective.
DOI: 10.6084/m9.figshare.22730336.v1
title: Personal protective equipment simulation training is associated with lower COVID-19 infection among healthcare workers

description: ABSTRACT Objective To describe the personal protective equipment training strategies during the beginning of the pandemic and to investigate the association between training and COVID-19 infection among healthcare workers. Methods This cross-sectional study conducted between March and May 2020 included 7,142 healthcare professionals who were eligible for both online and face-to-face simulation-based training on personal protective equipment use. Simulation training attendance was assessed by reviewing the attendance list, and the COVID-19 sick leave records recovered from the institutional RT-PCR database used to grant sick leave. The association between personal protective equipment training and COVID-19 was investigated using logistic regression, adjusted for sociodemographic and occupational characteristics. Results The mean age was 36.9 years (± 8.3), and 72.6% of participants were female. A total of 5,502 (77.0%) professionals were trained: 3,012 (54.7%) through online training, 691 (12.6%) through face-to-face training, and 1,799 (32.7%) through both strategies. During the study period, 584 (8.2%) COVID-19 cases were diagnosed among these professionals. The number of positive RT-PCR tests was 180 (11.0%) for untrained professionals, 245 (8.1%) for those trained only online, 35 (5.1%) for those trained face-to-face, and 124 (6.9%) for those trained with both strategies (p&lt;0.001). Participants who received face-to-face training had a 0.43 lower risk of contracting COVID-19. Conclusion Personal protective equipment training decreased the odds of COVID-19 among healthcare professionals, with face-to-face simulation-based training being most effective.
DOI: 10.6084/m9.figshare.22730340
title: Ella escribía poscrítica (despite the ruins): Margarita Mateo Palmer between criticism and fiction

description: Abstract This paper presents an analysis of Ella escribía poscrítica, by Margarita Mateo Palmer, first published in 1995, with a second definitive edition in 2005. More than to discuss its argument, we seek to analyze the book's characteristic genre transgressions and read it defending that it was constructed with the collage of diverse textualities. The main objective is to analyze some of the meanings produced by this writing strategy in literary criticism, especially regarding the relationship with the context of the Cuban Special Period.
DOI: 10.6084/m9.figshare.22730340.v1
title: Ella escribía poscrítica (despite the ruins): Margarita Mateo Palmer between criticism and fiction

description: Abstract This paper presents an analysis of Ella escribía poscrítica, by Margarita Mateo Palmer, first published in 1995, with a second definitive edition in 2005. More than to discuss its argument, we seek to analyze the book's characteristic genre transgressions and read it defending that it was constructed with the collage of diverse textualities. The main objective is to analyze some of the meanings produced by this writing strategy in literary criticism, especially regarding the relationship with the context of the Cuban Special Period.
DOI: 10.6084/m9.figshare.22730342
title: Voices are much more than a symptom

description: Abstract The international Hearing Voices Movement, which emerged in the 1980s, understands the phenomenon of hearing voices not just as a symptom, but helps in the development of strategies to deal with these voices. The objective of this study was to understand how people who participated in groups of voice hearers in the Brazilian health system dealt with such experiences. This was a qualitative research study, carried out in 2020, with data collection from in-depth interviews and field diary, analyzed using content analysis. Adult participants (4) attended the group for more than a month. It was possible to explore the individual coping strategies developed from the experiences of each one with their voices. The group was also an instrument of socialization and, from the normalization of the experience, of greater self-acceptance and reduction of stigma.
DOI: 10.6084/m9.figshare.22730342.v1
title: Voices are much more than a symptom

description: Abstract The international Hearing Voices Movement, which emerged in the 1980s, understands the phenomenon of hearing voices not just as a symptom, but helps in the development of strategies to deal with these voices. The objective of this study was to understand how people who participated in groups of voice hearers in the Brazilian health system dealt with such experiences. This was a qualitative research study, carried out in 2020, with data collection from in-depth interviews and field diary, analyzed using content analysis. Adult participants (4) attended the group for more than a month. It was possible to explore the individual coping strategies developed from the experiences of each one with their voices. The group was also an instrument of socialization and, from the normalization of the experience, of greater self-acceptance and reduction of stigma.
DOI: 10.6084/m9.figshare.22730345
title: Performance assessment of Primary Health Care: balance and perspective for the ‘Previne Brasil’ Program

description: ABSTRACT This article describes and analyzes the response of municipal governments to the payment-for-performance guideline in Primary Health Care (PHC) in the ‘Previne Brasil’ (PB) program in the 2020-2022 period. By establishing the PB in 2019, the Ministry of Health (MS) broke with the PHC financing model, which was based on linear per capita transfer to municipalities and the Federal District. Under the new policy, financial transfers from the MS would result from the analysis of the results of seven performance indicators of health teams reported in the National Register of Health Establishments. The article evaluates the response of subnational governments to the indicators defined by the PB, using data from the Health Information System for Primary Care of the Ministry of Health. The municipalities showed low effectiveness in relation to the performance commitments proposed by the tripartite agreement of the PB in the three-year period investigated. In general, the coverage results agreed in PB are exceptionally low and especially indicative of the risk of an epidemic due to failure in vaccination actions. Decisions to implement payment for performance were repeatedly postponed by the MS, favoring the demobilization of municipal governments in the development of PHC actions.
DOI: 10.6084/m9.figshare.22730345.v1
title: Performance assessment of Primary Health Care: balance and perspective for the ‘Previne Brasil’ Program

description: ABSTRACT This article describes and analyzes the response of municipal governments to the payment-for-performance guideline in Primary Health Care (PHC) in the ‘Previne Brasil’ (PB) program in the 2020-2022 period. By establishing the PB in 2019, the Ministry of Health (MS) broke with the PHC financing model, which was based on linear per capita transfer to municipalities and the Federal District. Under the new policy, financial transfers from the MS would result from the analysis of the results of seven performance indicators of health teams reported in the National Register of Health Establishments. The article evaluates the response of subnational governments to the indicators defined by the PB, using data from the Health Information System for Primary Care of the Ministry of Health. The municipalities showed low effectiveness in relation to the performance commitments proposed by the tripartite agreement of the PB in the three-year period investigated. In general, the coverage results agreed in PB are exceptionally low and especially indicative of the risk of an epidemic due to failure in vaccination actions. Decisions to implement payment for performance were repeatedly postponed by the MS, favoring the demobilization of municipal governments in the development of PHC actions.
DOI: 10.6084/m9.figshare.22730348
title: The health systems resilience: notes for a research agenda for the SUS

description: ABSTRACT The COVID-19 pandemic highlighted the resilience of health systems. In this paper, we seek to explore elements to support a research agenda on resilience for the Unified Health System (SUS). First, based on a scoping review, we analyzed the conceptual and methodological development of resilience applied to health systems research both at international and national levels, identifying who the formulating groups are and what they propose as analytical frameworks. Then, we propose an analytical framework adapted for the Brazilian health system features. The framework underpinned the pointing out of critical issues to be investigated in research on SUS resilience, based on four dimensions: governance and leadership, financing, resources (workforce, infrastructure, medicines, and technologies), and service provision. Finally, we discuss opportunities and challenges for implementing a research agenda on resilience for the SUS.
DOI: 10.6084/m9.figshare.22730348.v1
title: The health systems resilience: notes for a research agenda for the SUS

description: ABSTRACT The COVID-19 pandemic highlighted the resilience of health systems. In this paper, we seek to explore elements to support a research agenda on resilience for the Unified Health System (SUS). First, based on a scoping review, we analyzed the conceptual and methodological development of resilience applied to health systems research both at international and national levels, identifying who the formulating groups are and what they propose as analytical frameworks. Then, we propose an analytical framework adapted for the Brazilian health system features. The framework underpinned the pointing out of critical issues to be investigated in research on SUS resilience, based on four dimensions: governance and leadership, financing, resources (workforce, infrastructure, medicines, and technologies), and service provision. Finally, we discuss opportunities and challenges for implementing a research agenda on resilience for the SUS.
DOI: 10.6084/m9.figshare.22730351
title: Association of human papillomavirus (HPV), p16, p53 and p63 expression with non-bilharzia-associated squamous cell carcinoma of the bladder and algorithm construction for histopathological grading prediction

description: ABSTRACT Objective To investigate the expression of human papillomavirus (HPV), p16, p53, and p63 in non-schistosomiasis-related squamous cell carcinoma of the bladder and to develop an accurate and automated tool to predict histological classification based on clinicopathological features. Methods Twenty-eight patients with primary bladder pure squamous cell carcinoma who underwent cystectomy or transurethral resection of bladder tumor (TURBT) for bladder cancer between January 2011 and July 2017 were evaluated. Clinical data and follow-up information were obtained from medical records. Formalin-fixed, paraffin-embedded surgical specimens were used for immunohistochemical staining for p16, p53, and p63. Human papillomavirus detection was evaluated by PCR. Statistical analysis was performed, and statistical significance was set at p&lt;0.05. Finally, decision trees were built to classify patients’ prognostic features. Leave-one-out cross-validation was used to test the generalizability of the model. Results Neither direct HPV detection nor its indirect marker (p16 protein) was identified in most cases. The absence of p16 was correlated with less aggressive histological grading (p=0.040). The positive p16 staining detection found only in pT1 and pT2 cases in our sample suggests a possible role for this tumor suppressor protein in the initial stages of bladder squamous cell carcinoma. The decision trees constructed described the relationship between clinical features, such as hematuria/dysuria, the level of tumor invasion, HPV status, lymphovascular invasion, gender, age, compromised lymph nodes, and tumor degree differentiation, with high classification accuracy. Conclusion The algorithm classifier approach established decision pathways for semi-automatic tumor histological classification, laying the foundation for tailored semi-automated decision support systems for pathologists.
DOI: 10.6084/m9.figshare.22730351.v1
title: Association of human papillomavirus (HPV), p16, p53 and p63 expression with non-bilharzia-associated squamous cell carcinoma of the bladder and algorithm construction for histopathological grading prediction

description: ABSTRACT Objective To investigate the expression of human papillomavirus (HPV), p16, p53, and p63 in non-schistosomiasis-related squamous cell carcinoma of the bladder and to develop an accurate and automated tool to predict histological classification based on clinicopathological features. Methods Twenty-eight patients with primary bladder pure squamous cell carcinoma who underwent cystectomy or transurethral resection of bladder tumor (TURBT) for bladder cancer between January 2011 and July 2017 were evaluated. Clinical data and follow-up information were obtained from medical records. Formalin-fixed, paraffin-embedded surgical specimens were used for immunohistochemical staining for p16, p53, and p63. Human papillomavirus detection was evaluated by PCR. Statistical analysis was performed, and statistical significance was set at p&lt;0.05. Finally, decision trees were built to classify patients’ prognostic features. Leave-one-out cross-validation was used to test the generalizability of the model. Results Neither direct HPV detection nor its indirect marker (p16 protein) was identified in most cases. The absence of p16 was correlated with less aggressive histological grading (p=0.040). The positive p16 staining detection found only in pT1 and pT2 cases in our sample suggests a possible role for this tumor suppressor protein in the initial stages of bladder squamous cell carcinoma. The decision trees constructed described the relationship between clinical features, such as hematuria/dysuria, the level of tumor invasion, HPV status, lymphovascular invasion, gender, age, compromised lymph nodes, and tumor degree differentiation, with high classification accuracy. Conclusion The algorithm classifier approach established decision pathways for semi-automatic tumor histological classification, laying the foundation for tailored semi-automated decision support systems for pathologists.
DOI: 10.6084/m9.figshare.22730357
title: Baru Seed Extracted Oil (Dipteryx alata Vog.): Chemical Composition and Thermal and Oxidative Stability

description: Baru seeds are commonly found in the Brazilian savanna and present potential to be used by the food industry due to their high content of fat. In this sense, this study aimed to determine the physicochemical properties, and chemical composition of baru seed oil. The thermal and oxidative stability, as well as the interfacial properties of the oil were also evaluated. The free fatty acid, peroxide, moisture, density, viscosity and the refractive index of the oil extracted from baru seeds were 0.08% oleic acid, 6.69 meq O2 kg–1 of oil, 0.03%, 0.92 g cm–3, 32.9 mPa s and 1.47, respectively. Since linoleic acid (L), oleic acid (O), palmitic acid (P) and linolenic acid (Ln) are the main fatty acids present in the oil, the most common predominant triacylglycerols in the oil are POO, POL, OOO, OOL, OLL and LLL. The oil extracted from baru seeds presented good thermal and oxidative stability. Moreover, the oil contains high contents of total phenolics and carotenoids. The reduction of oil-water dynamic interfacial tension was promoted by the presence of small molecules. Therefore, the oil extracted from baru seeds presents promising properties for processing in the food industry.
DOI: 10.6084/m9.figshare.22730357.v1
title: Baru Seed Extracted Oil (Dipteryx alata Vog.): Chemical Composition and Thermal and Oxidative Stability

description: Baru seeds are commonly found in the Brazilian savanna and present potential to be used by the food industry due to their high content of fat. In this sense, this study aimed to determine the physicochemical properties, and chemical composition of baru seed oil. The thermal and oxidative stability, as well as the interfacial properties of the oil were also evaluated. The free fatty acid, peroxide, moisture, density, viscosity and the refractive index of the oil extracted from baru seeds were 0.08% oleic acid, 6.69 meq O2 kg–1 of oil, 0.03%, 0.92 g cm–3, 32.9 mPa s and 1.47, respectively. Since linoleic acid (L), oleic acid (O), palmitic acid (P) and linolenic acid (Ln) are the main fatty acids present in the oil, the most common predominant triacylglycerols in the oil are POO, POL, OOO, OOL, OLL and LLL. The oil extracted from baru seeds presented good thermal and oxidative stability. Moreover, the oil contains high contents of total phenolics and carotenoids. The reduction of oil-water dynamic interfacial tension was promoted by the presence of small molecules. Therefore, the oil extracted from baru seeds presents promising properties for processing in the food industry.
DOI: 10.6084/m9.figshare.22730352
title: Effect of Camellia sinensis Origin and Heat Treatment in the Iron Oxides Nanomaterials Composition and Fenton Degradation of Methyl Orange

description: Sustainable and environmentally friendly methods for nanomaterials synthesis have been emerging recently. The use of extracts of polyphenol-rich plants with high reducing and chelating power is advantageous because the polyphenol can protect the nanomaterial from agglomeration and deactivation. Green nanomaterials have been applied in several areas, including remediation of toxic organic pollutants from contaminated effluents. Herein, we describe the preparation of green iron oxide nanoparticles (IONPs) with extracts of the plant Camellia sinensis as black tea for dye removal application. The as-prepared IONPs were composed of amorphous FeOOH and FeII/III-polyphenol complexes. To obtain crystalline and pure iron-based nanomaterials, the amorphous precursor was annealed at 900 ºC. Samples of black tea from different regions were used to verify the reproducibility of the iron phases formed. The same iron phases were obtained for all black tea samples, α-Fe2O3 (hematite), FePO4, and Fe3PO7, but in different proportions. The materials were applied as heterogeneous-Fenton catalysts for the removal of the dye methyl orange. The amorphous as-prepared IONPs were more active than the respective annealed IONPs due to the proton release from the polyphenol into the reaction medium, setting the pH to around 3, which is the optimum pH for the Fenton system.
DOI: 10.6084/m9.figshare.22730352.v1
title: Effect of Camellia sinensis Origin and Heat Treatment in the Iron Oxides Nanomaterials Composition and Fenton Degradation of Methyl Orange

description: Sustainable and environmentally friendly methods for nanomaterials synthesis have been emerging recently. The use of extracts of polyphenol-rich plants with high reducing and chelating power is advantageous because the polyphenol can protect the nanomaterial from agglomeration and deactivation. Green nanomaterials have been applied in several areas, including remediation of toxic organic pollutants from contaminated effluents. Herein, we describe the preparation of green iron oxide nanoparticles (IONPs) with extracts of the plant Camellia sinensis as black tea for dye removal application. The as-prepared IONPs were composed of amorphous FeOOH and FeII/III-polyphenol complexes. To obtain crystalline and pure iron-based nanomaterials, the amorphous precursor was annealed at 900 ºC. Samples of black tea from different regions were used to verify the reproducibility of the iron phases formed. The same iron phases were obtained for all black tea samples, α-Fe2O3 (hematite), FePO4, and Fe3PO7, but in different proportions. The materials were applied as heterogeneous-Fenton catalysts for the removal of the dye methyl orange. The amorphous as-prepared IONPs were more active than the respective annealed IONPs due to the proton release from the polyphenol into the reaction medium, setting the pH to around 3, which is the optimum pH for the Fenton system.
DOI: 10.6084/m9.figshare.22730358
title: Synthesis of Isatins and Oxindoles Derivatives as SARS-CoV-2 Inhibitors Evaluated through Phenotypic Screening with Vero Cells

description: To expand the variety of density functionalized compounds evaluated against severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2), we decided to prepare new acetylated and disubstituted 3-hydroxy bis-oxindoles and isoindigos coupling compounds using known protocols. The corresponding isatin derivatives were synthesized by ZrCl4/EtOH/reflux or HCl/AcOH/reflux coupling conditions using oxindole and functionalized isatins, furnishing new 3-hydroxy bis-oxindoles, which were dehydrated into new isoindigos. A total of 27 compounds bearing halogen, nitro and/or hydroxy groups on the isatin moiety at the 3-, 5- and 7-positions, were prepared, including 5 new 3-hydroxy bis-oxindoles and 3 new halogenated isoindigos prepared according to adapted procedures described in the literature. This library of nitrogen-isatin derivatives was evaluated against SARS-CoV-2 using a phenotypic screening assay. In this investigation, isatin derivatives 3d, 3e, 3h and 3i showed antiviral activity when tested at a single concentration. Compound 3e showed antiviral activity against SARS-CoV-2 in the concentration-response assay; however, it showed cellular toxicity in Vero cells. The present study identified substituted isatins as a promising new starting point for the development of anti-SARS-CoV-2 agents.