cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.14318323.v1
title: Hypolipidemic and antioxidant effects of the juice and water seed extracts of two pomegranate species in high-cholesterol diet fed rats

description: Abstract This study investigated the hypolipidemic and antioxidant effects of the juice and water seed extracts of two pomegranate species from Saudi Arabia and Egypt, and compared them with each other as well as with ellagic acid (EA) in high-cholesterol diet (HCD) fed rats. Compared with the case in rats fed HCD alone, EA and juice or water seed extracts of both pomegranate types significantly reduced the levels of total cholesterol, triglycerides, LDL-c, and GSH, increased the level of HDL-c, increased the activity of SOD and CAT, and decreased the level of MDA in the serum of HCD-fed rats. There were more profound effects of the juice or water seed extract of both the Saudi and Egyptian pomegranates on serum HDL-c and GSH levels and the activities of SOD and CAT than those of EA. In conclusion, this study showed that water seed extracts or juice of both types of pomegranate ameliorated HCD-induced hyperlipidemia, lipid peroxidation, and changes of enzymatic and non-enzymatic antioxidants in the serum of HCD-fed rats.
DOI: 10.6084/m9.figshare.14318335.v1
title: “Yellow Araçá” flour (Psidium cattleyanum cv. Ya-cy) in cereal bars - nutritional and functional potential

description: Abstract Yellow Araçá (Psidium cattleyanum cv. Ya-cy) is a Brazilian native fruit that can be consumed fresh or turned into food products. However, distribution and consumption of fresh fruits are still limited due to faulty post-harvest handling. Thus, the present study aimed to evaluate the nutritional and functional potential of fresh Yellow Araçá fruit, turned into flour, in formulations of cereal bars. Ripe fruits preserved higher nutritional and functional indexes, presenting high antioxidant potential. As observed during the sensory analysis, addition up to 20% of fruit flour into the cereal bar was well accepted by the consumers. The cereal bar showed significant levels of omega-6 (n-6) and omega-9 (n-9), and minerals nutrients such as iron, magnesium, potassium, zinc. Significant levels of phenolic compounds and low levels of sodium and saturated fatty, free from trans fatty acids, were also observed. The cereal bar presented high amount of crude fiber content, indicating a high potential for use as a functional food.
DOI: 10.6084/m9.figshare.14318342.v1
title: miR-223-3p suppresses inflammation to protect cardiomyocytes by targeting NLRP3 in acute myocardial infarction patients

description: Abstract microRNA (miRNA) had been found played an important role in occurrence and development of acute myocardial infarction (AMI) disease. In this paper, we found that the circulating miR-223-3p in AMI patients was significantly higher than that in unstable angina (UA) patients and healthy people. Univariate and logistic regression analysis showed the circulating miR-223-3p was a protective factor in the occurrence of AMI. We also found that the circulating miR-223-3p was negatively correlated with the serum CK-MB, cTnI, AST, LDH, TNF-α, IL-6, IL-1β and IL-8. The luciferase reporter gene system confirmed that miR-223-3p targeted inhibition of NLRP3 expression in THP-1 and human peripheral blood mononuclear cell (PBMC), and miR-223-3p was negatively correlated with the expression of NLRP3 in the PBMC of AMI patients. In PBMC of healthy people, miR-146a-mimic could increase the expression of NLRP3, but decreased the level of TNF-α secretion. Moreover, H2C9 cells apoptosis by TNF-α in a dose-dependent. In conclusion, these results suggested that miR-223-3p suppressed inflammation to protect cardiomyocytes by targeting NLRP3 in AMI patients.
DOI: 10.6084/m9.figshare.14318344
title: Protective effect of sesame (sesamum indicum) seed oil against hypercholesterolemic in sprague-dawley male rats

description: Abstract To explore the protective effect of sesame seed oil (SSO) extracted from Til-06 sesame variety in Sprague-Dawley male rats against the management of hypercholesterolemia, the current two-phase study was conducted. In the first phase, oil was taken out from the sesame seeds (Til-06) and physicochemical analysis was carried out to find out the content of oil following by the evaluation of the quality attributes of extracted oil. In the second phase, efficacy was carried out to check the hyperlipidemic activity of sesame seed oil. Randomly distributed twenty (20) rats into 5 different groups with four (04) rats in each group and for 60 days fed as follow; the first group was fed on a basal diet, while the other groups were fed with 2, 4, 6 and 8% SSO plus basal diet. Blood samples were collected at the beginning and end of the study for biochemical study i.e. lipid profile which includes high-density lipoprotein (HDL-C), triglycerides (TG), low-density lipoprotein (LDL-C), total cholesterol (TC), and very-low-density lipoprotein (VLDL) and antioxidant status. Findings of the present study indicate that the oral administration of SSO significantly (P &lt; 0.05) improved the antioxidant status with lower TC, LDL-C, TG, VLDL-C, and higher HDL-C values of hypercholesterolemic rats.
DOI: 10.6084/m9.figshare.14318344.v1
title: Protective effect of sesame (sesamum indicum) seed oil against hypercholesterolemic in sprague-dawley male rats

description: Abstract To explore the protective effect of sesame seed oil (SSO) extracted from Til-06 sesame variety in Sprague-Dawley male rats against the management of hypercholesterolemia, the current two-phase study was conducted. In the first phase, oil was taken out from the sesame seeds (Til-06) and physicochemical analysis was carried out to find out the content of oil following by the evaluation of the quality attributes of extracted oil. In the second phase, efficacy was carried out to check the hyperlipidemic activity of sesame seed oil. Randomly distributed twenty (20) rats into 5 different groups with four (04) rats in each group and for 60 days fed as follow; the first group was fed on a basal diet, while the other groups were fed with 2, 4, 6 and 8% SSO plus basal diet. Blood samples were collected at the beginning and end of the study for biochemical study i.e. lipid profile which includes high-density lipoprotein (HDL-C), triglycerides (TG), low-density lipoprotein (LDL-C), total cholesterol (TC), and very-low-density lipoprotein (VLDL) and antioxidant status. Findings of the present study indicate that the oral administration of SSO significantly (P &lt; 0.05) improved the antioxidant status with lower TC, LDL-C, TG, VLDL-C, and higher HDL-C values of hypercholesterolemic rats.
DOI: 10.6084/m9.figshare.14318345
title: Development and characterization of edible bilayer films based on iron yam–pea starch blend and corn zein

description: Abstract We prepared bilayer films of iron yam–pea starch and corn zein to evaluate their potential application in the packaging of instant foods and condiments. We found that the water resistance and mechanical properties of bilayer films were improved after adding a layer of corn zein compared with the monolayer films of the starch materials. Scanning electron microscopy revealed that the bilayers were close and this was reflected in increased thermal stability and biocompatibility between layers with the addition of zein. Our experimental films showed greater elongation at break than the commercial biaxially oriented polypropylene polyethylene films. Based on the results of this study, the iron yam-pea starch/corn zein films have the mechanical strength and flexibility to be used for convenience food packaging materials, which are expected to provide consumers with clean products.
DOI: 10.6084/m9.figshare.14318349
title: Postharvest ascorbic acid application maintained physiological and antioxidant responses of Guava (Psidium guajava L.) at ambient storage

description: Abstract Guava (Psidium guajava) is a highly perishable fruit with a short shelf life as physico-chemical changes occur continuously and rapidly after harvest leading to heavy postharvest losses. This experiment was laid down to unravel the effects of ascorbic acid (AA) on ripened guava fruits to improve its shelf life and quality. Four different concentrations of AA namely 0, 50, 100, 200 ppm were used to treat guava fruit for five minutes followed by storage at 25±2 °C and ≥80% relative humidity (RH) for 12 days. Physiological and biochemical changes were studied, together with the specific enzymatic activities for catalase (CAT), superoxide dismutase (SOD) and peroxidase (POD). The results revealed that ascorbic acid treatments significantly reduced PWL, fruit decay percentage and suppressed pH and sugar/acid ratio than control fruits. Furthermore, soluble solid content, total acidity, total sugar, vitamin C and total phenolic contents were recorded higher in 200 ppm AA-treated fruits and maintained higher eating quality than control fruits. In addition, SOD, POD and CAT activities were observed higher in 200 ppm AA-treated fruits than control. The results clearly demonstrate that 200 ppm AA application have a potential to improve quality attributes of guava fruit.
DOI: 10.6084/m9.figshare.14318351
title: Improved diagnosis of tuberculous pleural effusion by combining medical thoracoscopy with Interferon-Gamma Release Assay and adenosine deaminase activity

description: Abstract Rapid, accurate, affordable, point-of-care tuberculosis (TB) diagnostic tests are essential for controlling TB. We aimed evaluate the diagnostic performance of tuberculous pleural effusion by combining medical thoracoscopy with blood interferon-gamma release assay (IGRA) and pleural fluid adenosine deaminase (ADA). Patients with undiagnosed pleural effusion measured by chest X-ray or ultrasound were prospectively enrolled in this study. Medical thoracoscopy, blood IGRA and pleural fluid ADA were conducted.A total of 154 patients with undiagnosed pleural effusion were enrolled. Among them, 98 patients (63.6%) were diagnosed as TPE. Patients in TPE+ groups were significantly younger. The diagnostic thresholds obtained via receiver operating characteristic curve analysis were: ADA 23.4 U/L with AUC 0.91 (95% CI: 0.85-0.97, Figure 2) and IFN-γ 6.9 pg/mL with AUC 0.87 (95% CI: 0.82-0.93). By combining all three test together, we achieved sensitivity of 0.92, perfect specificity and NLR of 0.082. The AUC of the combination test was 0.96 (0.93-0.99), which was significant higher than any individual test (p &lt; 0.001). The combination of medical thoracoscopy with Interferon-Gamma release assay and adenosine deaminase performs better than individual test in diagnosis TPE. The combination diagnosis has very high diagnostic rate, can be easily and safely carried out.
DOI: 10.6084/m9.figshare.14318349.v1
title: Postharvest ascorbic acid application maintained physiological and antioxidant responses of Guava (Psidium guajava L.) at ambient storage

description: Abstract Guava (Psidium guajava) is a highly perishable fruit with a short shelf life as physico-chemical changes occur continuously and rapidly after harvest leading to heavy postharvest losses. This experiment was laid down to unravel the effects of ascorbic acid (AA) on ripened guava fruits to improve its shelf life and quality. Four different concentrations of AA namely 0, 50, 100, 200 ppm were used to treat guava fruit for five minutes followed by storage at 25±2 °C and ≥80% relative humidity (RH) for 12 days. Physiological and biochemical changes were studied, together with the specific enzymatic activities for catalase (CAT), superoxide dismutase (SOD) and peroxidase (POD). The results revealed that ascorbic acid treatments significantly reduced PWL, fruit decay percentage and suppressed pH and sugar/acid ratio than control fruits. Furthermore, soluble solid content, total acidity, total sugar, vitamin C and total phenolic contents were recorded higher in 200 ppm AA-treated fruits and maintained higher eating quality than control fruits. In addition, SOD, POD and CAT activities were observed higher in 200 ppm AA-treated fruits than control. The results clearly demonstrate that 200 ppm AA application have a potential to improve quality attributes of guava fruit.
DOI: 10.6084/m9.figshare.14318353
title: Physicochemical, microbiological and sensory characteristics of goats reared on organic rationing in Karakoram region

description: Abstract Goat meat is consumed all over the world because of its nutritional profile and delicacy. It is produced in all areas of Pakistan but the meat produced in the Karakoram region of the Pakistan is mostly organic and the animals are fed on the natural vegetation having nutrition benefits for humans. In current study, goats were reared on the different systems having natural flora of alfalfa and grass hey (MS I) sea buckthorn (MS II), Russian Olive (MS III) and the mix ration of sea buckthorn and Russian olive (MS IV). The animals were reared for 6 months and after slaughtering evaluated for fatty acids, physiochemical, microbiological and the sensory evaluation of the smoked meat. It has been observed that the meat has microbiological quality on acceptable degrees, fatty acid profile of the meat was best for MS IV, mineral and sensory characteristics, color and physical properties for all treatments remained non-significant. The basic choice for health-conscious consumer is on the profile of fatty acids in the meat so on the basis of data it could be suggested that the meat fed on the sea buck thorn and Russian olive is best among all treatments.
DOI: 10.6084/m9.figshare.14318352
title: Ameliorative effects of fenugreek (Trigonella foenum-graecum) seed on type 2 diabetes

description: Abstract The hyperglycaemia defines features of type 2 diabetes (T2DM), which is a real time problem and poses a significant economic burden on the globe and is spreading like an epidemic. Currently it affects 384 million people on the globe and this number is expected to reach 592 million in 2035 as reiterated by International Diabetes Federation (IDF). By improving the quality of diet and decreasing the intake of sugary foods T2DM can be treated. Fenugreek seeds powder in sachet form of 20 g/day used to treat type 2 diabetes mellitus as a natural supplement. Anthropometric parameters of height, weight, age and BMI of T2DM patient was also calculated. In this study patients from Rawalpindi and Islamabad region were selected for study purpose. Blood sugar levels such as fasting blood glucose (FBG), random blood glucose (RBG), and HbA1c of both the groups (treated and control) were taken at baseline, after one month and at the end of study. When fenugreek seeds were given to T2DM patients significant decrease in their glucose levels were seen after 30 and then 60 days of treatment.
DOI: 10.6084/m9.figshare.14318345.v1
title: Development and characterization of edible bilayer films based on iron yam–pea starch blend and corn zein

description: Abstract We prepared bilayer films of iron yam–pea starch and corn zein to evaluate their potential application in the packaging of instant foods and condiments. We found that the water resistance and mechanical properties of bilayer films were improved after adding a layer of corn zein compared with the monolayer films of the starch materials. Scanning electron microscopy revealed that the bilayers were close and this was reflected in increased thermal stability and biocompatibility between layers with the addition of zein. Our experimental films showed greater elongation at break than the commercial biaxially oriented polypropylene polyethylene films. Based on the results of this study, the iron yam-pea starch/corn zein films have the mechanical strength and flexibility to be used for convenience food packaging materials, which are expected to provide consumers with clean products.
DOI: 10.6084/m9.figshare.14318351.v1
title: Improved diagnosis of tuberculous pleural effusion by combining medical thoracoscopy with Interferon-Gamma Release Assay and adenosine deaminase activity

description: Abstract Rapid, accurate, affordable, point-of-care tuberculosis (TB) diagnostic tests are essential for controlling TB. We aimed evaluate the diagnostic performance of tuberculous pleural effusion by combining medical thoracoscopy with blood interferon-gamma release assay (IGRA) and pleural fluid adenosine deaminase (ADA). Patients with undiagnosed pleural effusion measured by chest X-ray or ultrasound were prospectively enrolled in this study. Medical thoracoscopy, blood IGRA and pleural fluid ADA were conducted.A total of 154 patients with undiagnosed pleural effusion were enrolled. Among them, 98 patients (63.6%) were diagnosed as TPE. Patients in TPE+ groups were significantly younger. The diagnostic thresholds obtained via receiver operating characteristic curve analysis were: ADA 23.4 U/L with AUC 0.91 (95% CI: 0.85-0.97, Figure 2) and IFN-γ 6.9 pg/mL with AUC 0.87 (95% CI: 0.82-0.93). By combining all three test together, we achieved sensitivity of 0.92, perfect specificity and NLR of 0.082. The AUC of the combination test was 0.96 (0.93-0.99), which was significant higher than any individual test (p &lt; 0.001). The combination of medical thoracoscopy with Interferon-Gamma release assay and adenosine deaminase performs better than individual test in diagnosis TPE. The combination diagnosis has very high diagnostic rate, can be easily and safely carried out.
DOI: 10.6084/m9.figshare.14318355.v1
title: Wine composition of Merlot and Cabernet Sauvignon vine clones under the environmental conditions of Serra Gaúcha, Brazil

description: Abstract This study aimed to evaluate the wine composition from vine clones of Merlot (181, 346, 347, 348) and Cabernet Sauvignon (R5, 18A, 163, 338, 341). The grapes were harvested between 2010 and 2012, then on the same day, taken to the winery facility for winemaking. After crushing and destemming the grapes, the musts were transferred to glass containers, where the alcoholic and later malolactic fermentations occurred. Next, the wines were bottled and analyzed, where the classical variables were determined by physicochemical methods, volatile compounds by gas chromatography, and minerals by atomic absorption spectrophotometry. Data were submitted to ANOVA, Tukey test, correlation analysis, and Principal Component Analysis. The clone effect was significant for some variables; however, year and varietal group exerted greater effects. The Merlot group generally had higher values of ethanol, absorbance at 520 nm, color intensity, total polyphenols index, and methanol. On the other hand, the Cabernet Sauvignon group presented higher pH, ashes, alkalinity of ashes, hue, and potassium. Therefore, the three-year average data demonstrate that the evaluated Merlot and Cabernet Sauvignon clones are suitable to produce quality wines in the region, especially Merlot 181, 346, and 348 and Cabernet Sauvignon 18A and 163.
DOI: 10.6084/m9.figshare.14318356
title: Mineral profile and characterisation of cookies made from legume green grain flour

description: Abstract The aim of this work was to determine and compare the mineral composition and physico-chemical parameters of formulations of cookies developed by hand based on Lablab purpureus (L.) Sweet (mangalo—BFM), Vigna unguiculata (L.) Walp. (cowpea beans—BFC) and Cajanus cajan (L.) Huth (pigeon pea—BFP) flours. The results indicate that the cookies have a high content of essential minerals (mainly K, P and Ca). Moisture (4.48-8.44%) was below the maximum value established by Brazilian legislation, and lipids (6.35-6.56%) and ash (3.33-3.96%) were like products found in the market and literature. High levels of protein (8.37-9.28%), fibre (3.88-6.39%) and carbohydrates (66.28-71.19%) give the product high nutritional potential. No oxidation products were detected. Water activity and acidity remained satisfactory for good food preservation for 45 days. Sensory evaluation indicates a satisfactory acceptability for the BFM and BFC (overall quality above 7). The desirability data indicated that the BFC obtained the best performance for the chosen parameters. Therefore, the elaborated cookies have high nutritional quality and the pulse flour has potential for the enrichment of food products.
DOI: 10.6084/m9.figshare.14318353.v1
title: Physicochemical, microbiological and sensory characteristics of goats reared on organic rationing in Karakoram region

description: Abstract Goat meat is consumed all over the world because of its nutritional profile and delicacy. It is produced in all areas of Pakistan but the meat produced in the Karakoram region of the Pakistan is mostly organic and the animals are fed on the natural vegetation having nutrition benefits for humans. In current study, goats were reared on the different systems having natural flora of alfalfa and grass hey (MS I) sea buckthorn (MS II), Russian Olive (MS III) and the mix ration of sea buckthorn and Russian olive (MS IV). The animals were reared for 6 months and after slaughtering evaluated for fatty acids, physiochemical, microbiological and the sensory evaluation of the smoked meat. It has been observed that the meat has microbiological quality on acceptable degrees, fatty acid profile of the meat was best for MS IV, mineral and sensory characteristics, color and physical properties for all treatments remained non-significant. The basic choice for health-conscious consumer is on the profile of fatty acids in the meat so on the basis of data it could be suggested that the meat fed on the sea buck thorn and Russian olive is best among all treatments.
DOI: 10.6084/m9.figshare.14318358
title: Comparison of multispectral modeling of physiochemical attributes of greengage: Brix and pH values

description: Abstract Chemometric modeling concerns both accuracy and computational expense for the prediction of quality-indicating attributes of food materials. Modeling approaches were explored with the hyperspectral images with pH and Brix values of greengages. A two-phase architecture was applied for modeling. Firstly, waveband selection was performed using two approaches, i.e., succession projection algorithm (SPA) and its combination with genetic algorithm (SPA+GA). Secondly, multispectral models based on the two feature sets of wavebands were built via a total of six different modeling methods, i.e., partial least squares regression (PLSR) and extreme learning machine (ELM) in their respective stand-alone versions, their applications combined with genetic algorithm (GA), and their ensemble enhancements with modified Adaboost.RT (MAdaboost.RT). Analysis of accuracy and computational expense showed that supervised feature selection with SPA+GA was superior to unsupervised SPA for better modeling accuracy. MAdaboost.RT-ELM showed high accuracy at low computational expense. ELM models were the better base models than the PLSR ones, for being more randomized and diverse. It indicates that MAdaboost.RT-ELM on SPA is the best choice for a quick test on a newly available dataset, while switching the dimensionality reduction from SPA to SPA+GA may yield more accurate models with added, but well worthy, computational expense.