DOI: 10.7270/q22n52n1
title: BindingDB Entry 50034012: Discovery of 3-(2,6-dichloro-3,5-dimethoxy-phenyl)-1-{6-[4-(4-ethyl-piperazin-1-yl)-phenylamino]-pyrimidin-4-yl}-1-methyl-urea (NVP-BGJ398), a potent and selective inhibitor of the fibroblast growth factor receptor family of receptor tyrosine kinase.

description: Small molecule binding data for protein AKT/p21CIP1, ALK tyrosine kinase receptor, AXL receptor tyrosine kinase, CAMK2B, Casein kinase I isoform gamma-3, Cyclin-dependent kinase 1, Cyclin-dependent kinase 2, Cyclin-dependent kinase 4, Cytochrome P450 1A, Cytochrome P450 2C19, Cytochrome P450 2C9, Cytochrome P450 2D6 (2D6), Cytochrome P450 3A, EPHB1, Ephrin receptor, Ephrin type-B receptor 4 (EphB4), Epidermal growth factor receptor, Epidermal growth factor receptor and ErbB2 (HER1 and HER2), Fibroblast growth factor receptor 1, Fibroblast growth factor receptor 2, Fibroblast growth factor receptor 3, Fibroblast growth factor receptor 4, Focal adhesion kinase 1/vascular endothelial growth factor receptor 3, Glycogen synthase kinase-3, Hepatocyte growth factor receptor, Insulin receptor, Insulin-like growth factor I receptor, Interleukin-1 receptor-associated kinase 4, JAK2/TYK2, JAK3/JAK1, Kinesin-1 heavy chain/ Tyrosine-protein kinase receptor RET, MAP kinase ERK2, MAP kinase signal-integrating kinase 2, MAP kinase-activated protein kinase 2, MAP kinase-activated protein kinase 5, MAP kinase-interacting serine/threonine-protein kinase MNK1, MER intracellular domain/EGFR extracellular domain chimera, Macrophage-stimulating protein receptor, Mitogen-activated protein kinase 10, Mitogen-activated protein kinase 14, Mitogen-activated protein kinase 9, Mitogen-activated protein kinase kinase kinase 8, Neurotrophic tyrosine kinase receptor type 2, PI3-kinase subunit alpha, PI3-kinase subunit beta, PI3-kinase subunit delta, Phosphatidylinositol 3-kinase catalytic subunit type 3, Phosphatidylinositol 4-kinase beta (PIK4KB), Platelet-derived growth factor receptor, Protein kinase C alpha type, Protein kinase C theta type, Protein kinase N1, Protein kinase N2, Proto-oncogene tyrosine-protein kinase ROS, Pyruvate dehydrogenase kinase isoenzyme 1 (PDK1), Receptor tyrosine-protein kinase erbB-4 (HER4), Rho-associated protein kinase, SRC, Serine/threonine-protein kinase Aurora, Serine/threonine-protein kinase PIM, Serine/threonine-protein kinase PLK1, Serine/threonine-protein kinase WNK1, Serine/threonine-protein kinase mTOR, Tyrosine-protein kinase ABL1, Tyrosine-protein kinase BMX, Tyrosine-protein kinase BTK, Tyrosine-protein kinase CSK, Tyrosine-protein kinase JAK1, Tyrosine-protein kinase JAK2, Tyrosine-protein kinase Kit (Kit), Tyrosine-protein kinase SYK, Tyrosine-protein kinase Yes, Tyrosine-protein kinase ZAP-70, Tyrosine-protein kinase receptor FLT3, VEGF-receptor 2 and tyrosine-protein kinase SRC, Vascular endothelial growth factor receptor, Vascular endothelial growth factor receptor 2, Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2), p21-Activated kinase 2 (PAK2), and p38 delta/gamma, Uniprot L7RSL3, O00329, O14965, O60674, O75116, P00519, P00533, P04626, P05177, P06213, P06239, P06241, P06493, P07947, P07948, P07949, P08069, P08581, P08631, P08684, P08922, P10635, P10721, P11362, P11712, P11802, P12931, P16234, P17252, P17948, P21802, P22455, P22607, P23458, P24941, P28482, P29597, P30530, P31749, P33261, P35916, P35968, P36888, P41240, P41279, P42336, P42338, P42345, P43403, P43405, P45984, P49137, P49841, P51813, P52333, P53350, P53778, P53779, P54760, P54762, P54764, Q02763, Q04759, Q04912, Q05397, Q06187, Q12866, Q13177, Q13554, Q15118, Q15303, Q16512, Q16513, Q16539, Q16620, Q541P7, Q8IW41, Q8NEB9, Q9BUB5, Q9H4A3, Q9HBH9, Q9NWZ3, Q9P1W9, Q9UBF8, Q9UM73, and Q9Y6M4