cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.21081005.v1
title: Adipose-derived mesenchymal stem cell-secreted extracellular vesicles alleviate non-alcoholic fatty liver disease <i>via</i> delivering miR-223-3p

description: Increasing studies have identified the potential of mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) in non-alcoholic fatty liver disease (NAFLD) treatment. Hence, we further focused on the potential of adipose-derived MSC (ADSC)-EVs in NAFLD by delivering miR-223-3p. The uptake of isolated ADSC-EVs by hepatocytes was assessed, and the expression of miR-223-3p in ADSC-EVs and hepatocytes was characterized. It was established that miR-223-3p, enriched in ADSC-EVs, could be delivered by ADSC-EVs into hepatocytes. Using co-culture system and gain-of-function approach, we evaluated the effect of ADSC-EVs carrying miR-223-3p on lipid accumulation and liver fibrosis in pyrrolizidine alkaloids (PA)-induced hepatocytes and a high-fat diet-induced NAFLD mouse model. Bioinformatics websites and dual-luciferase reporter gene assay were performed to determine the interactions between miR-223-3p and E2F1, which was further validated by rescue experiments. ADSC-EVs containing miR-223-3p displayed suppressive effects on lipid accumulation and liver fibrosis through E2F1 inhibition, since E2F1 was demonstrated as a target gene of miR-223-3p. The protective role of ADSC-EVs by delivering miR-223-3p was then confirmed in the mouse model. Collectively, this study elucidated that ADSC-EVs delayed the progression NAFLD through the delivery of anti-fibrotic miR-223-3p and subsequent E2F1 suppression, which may suggest miR-223-3p-loaded ADSC-EVs to be a potential therapeutic approach for NAFLD.
DOI: 10.6084/m9.figshare.21081154.v1
title: Design and <i>in silico</i> analysis of mRNA vaccine construct against <i>Salmonella</i>

description: <i>Salmonella</i> infections are continuously growing. Causative serovars have gained enhanced drug resistance and virulence. Current vaccines have fallen short of providing sufficient protection. mRNA vaccines have come up with huge success against SARS-CoV-2; Pfizer-BioNTech and Moderna vaccines have resulted in &gt;90% efficacy with efficient translocation, expression, and presentation of antigen to the host immune system. Herein, based on the same approach a mRNA vaccine construct has been designed and analyzed against <i>Salmonella</i> by joining regions of genes of outer membrane proteins C and F of <i>S</i>. Typhi through a flexible linker. Construct was flanked by regulatory regions that have previously shown better expression and translocation of encoded protein. GC content of the construct was improved to attain structural and thermodynamic stability and smooth translation. Sites of strong binding miRNAs were removed through codon optimization. Protein encoded by this construct is structurally plausible, highly antigenic, non-allergen to humans, and does not cross-react to the human proteome. It is enriched in potent, highly antigenic, and conserved linear and conformational epitopes. Most conserved conformational epitopes of core protein lie on extended beta hairpins exposed to the cellular exterior. Stability and thermodynamic attributes of the final construct were found highly comparable to the Pfizer-BioNTech vaccine construct. Both contain a stable stem-loop structure downstream of the start codon and do not offer destabilizing secondary structures upstream of the start codon. Given structural and thermodynamic stability, effective immune response, and epitope composition the construct is expected to provide broad-spectrum protection against clinically important <i>Salmonella</i> serovars. Communicated by Ramaswamy H. Sarma
DOI: 10.6084/m9.figshare.24312670
title: Data-centric artificial olfactory system based on the eigengraph

description: 1. Source Data File
2. ATX Data and DNN Code
3. Exhaust Gas Code (DNN)
4. Exhaust Gas Code (CNN)
5. Exhaust Gas Code (CNN-LSTM)
6. Exhaust Gas Data
DOI: 10.17632/2wf998hxfv.1
title: Comparison of ten sequential online motor assessment of patients with Parkinson disease by multiple raters in different locations

description: Detection of movements in the extremities of people with Parkinson disease was developed to enhance clinical assessments. This data represents the administration of online motor assessments to detect the movements in the extremities of people with Parkinson's disease by examiners certified in the Movement Disorders Society-sponsored revision of the Unified Parkinson’s Disease Rating Scale (MDS-UPDRS) (Goetz, et al., 2008). 


Ten trained raters who were certified in the administration of the Movement Disorders Society-sponsored revision of the Unified Parkinson’s Disease Rating Scale (MDS-UPDRS) (Goetz, et al., 2008) conducted 10 online motor assessments for one patient with Parkinson disease. Each rater utilized a separate computer at different location in three continents. At the beginning of each session the patient was asked for his permission to record the session. Second, the investigator asked the patient about the current medications and weight. Third, the investigator announced each motor assessment by saying the number and the name of each task before conducting the task for all of the raters. Fourth, the investigator gave the patient the specific instructions for each task, demonstrated each task, and asked the participant to begin the task. The investigator didn't continue to demonstrate the task after the participant began the task. For the repetitive items the investigator asked the participant to perform the activities as fully and as fast as possible. After performing each task the raters were given one minute to write their scores. This process was repeated for all of the tasks. At the conclusion of the session the participant was excused after setting the next session date, and then all of the raters shared their scores with the investigator by email. Finally the investigator conducted a consensus conference to attain agreement on each score for each task. 



One expert certified in the MDS-UPDRS (Goetz, et al., 2008) edited the original videotapes to extract only the administration of each task.The videotape segments correspond to the tasks of the protocol (3.17RTU: 3.17 Rest tremor amplitude upper limbs, 3.17RTUC: 3.17 Rest tremor amplitude upper limbs counting, 3.15PT: 3.15 Postural tremor of the hands, 3.4FT: 3.4 Finger tapping, 3.5HM: 3.5 Hand movements, 3.6PS: 3.6 Pronation-supination movements of the hands, 3.9ACU: 3.9 Arising from chair upper limbs).
DOI: 10.6084/m9.figshare.16886874.v1
title: Syntactic priming across highly similar languages is not affected by language proficiency

description: This study explores the mechanism underlying shared syntactic representations for highly similar languages by investigating whether cross-linguistic syntactic priming is affected by language proficiency. In two experiments, native (L1) Mandarin-Chaoshanese speakers with moderate proficiency in Cantonese (L2) heard Chaoshanese and Cantonese dative sentences with a prepositional object (PO) or a double object (DO) structure, and then completed a description of a depicted ditransitive event using Mandarin. Priming from L2 to L1 was equal to that from L1 to L1, irrespective of whether the prime and the target involved cognate verbs. Similarly, priming from L2 to L1 was not affected by speakers’ L2 proficiency, suggesting that shared representations across highly similar languages are insensitive to language proficiency. We interpret the results in terms of the development of shared representations for highly similar languages.
DOI: 10.6084/m9.figshare.24312670.v1
title: Data-centric artificial olfactory system based on the eigengraph

description: 1. Source Data File
2. ATX Data and DNN Code
3. Exhaust Gas Code (DNN)
4. Exhaust Gas Code (CNN)
5. Exhaust Gas Code (CNN-LSTM)
6. Exhaust Gas Data
DOI: 10.6084/m9.figshare.5876646
title: Late Cretaceous tectono-magmatic activity in the Nize region, central Tibet: evidence for lithospheric delamination beneath the Qiangtang–Lhasa collision zone

description: The results of zircon U–Pb age dating and whole-rock geochemistry for the Late Cretaceous Nize granodiorite porphyries, combined with analysis of near-coeval structural deformation of the Lower Cretaceous Langshan Formation, provide new data to better understand the tectonic evolution of the northern Lhasa subterrane, central Tibet. Zircon U–Pb ages of 89.2 ± 0.3 Ma to 87.8 ± 0.3 Ma indicate emplacement during the Late Cretaceous. Granodiorite porphyry intrusions were contemporaneous with the development of a regional angular unconformity, overlain by the Upper Cretaceous Jingzhushan (or Abushan) Formation, within the collision zone between the South Qiangtang and Lhasa terranes. Geochemical data for Nize granodiorite porphyries indicate that they have a calc-alkaline composition enriched in large-ion lithophile elements and light rare earth elements and depleted in high-field-strength elements and heavy rare earth elements. High Al<sub>2</sub>O<sub>3</sub> and Sr contents, low Yb and Y contents, and high Sr/Y ratios are similar to adakitic magmas. Structural analysis indicates two stages of deformation (D<sub>1</sub> and D<sub>2</sub>), with D<sub>1</sub> forming the focus of the present study. The D<sub>1</sub> deformation is represented by large-scale faults and records two periods of faulting. These periods are recognized as early compressional thrust faulting and a dominant late stage characterized by normal faulting and extension, with the latter stages of D<sub>1</sub> being near-coeval with the emplacement of the Nize granodiorite porphyries. The combination of zircon ages, geochemical data, and structural analysis indicates that the Nize granodiorite porphyries formed after collision of the South Qiangtang and Lhasa terranes. Adakitic magma derived from partial melting of the thickened lower or middle crust resulted from lithospheric delamination that may have been promoted by the convective removal of deeper lithospheric mantle.
DOI: 10.17632/46kg8d7nnv.1
title: Push-pull suture: Supplementary Videos

description: Supplementary Video 1. Intra-op video demonstration of technique of push-pull suture on the face
Supplementary Video 2. Intra-op video demonstration of technique of push-pull suture in a large scar on the back
DOI: 10.6084/m9.figshare.24076626
title: Therapeutic mitigation of measles-like immune amnesia and exacerbated disease after consecutive respiratory virus infections in ferrets

description: All quantitative source data.
DOI: 10.6084/m9.figshare.5876646.v1
title: Late Cretaceous tectono-magmatic activity in the Nize region, central Tibet: evidence for lithospheric delamination beneath the Qiangtang–Lhasa collision zone

description: The results of zircon U–Pb age dating and whole-rock geochemistry for the Late Cretaceous Nize granodiorite porphyries, combined with analysis of near-coeval structural deformation of the Lower Cretaceous Langshan Formation, provide new data to better understand the tectonic evolution of the northern Lhasa subterrane, central Tibet. Zircon U–Pb ages of 89.2 ± 0.3 Ma to 87.8 ± 0.3 Ma indicate emplacement during the Late Cretaceous. Granodiorite porphyry intrusions were contemporaneous with the development of a regional angular unconformity, overlain by the Upper Cretaceous Jingzhushan (or Abushan) Formation, within the collision zone between the South Qiangtang and Lhasa terranes. Geochemical data for Nize granodiorite porphyries indicate that they have a calc-alkaline composition enriched in large-ion lithophile elements and light rare earth elements and depleted in high-field-strength elements and heavy rare earth elements. High Al<sub>2</sub>O<sub>3</sub> and Sr contents, low Yb and Y contents, and high Sr/Y ratios are similar to adakitic magmas. Structural analysis indicates two stages of deformation (D<sub>1</sub> and D<sub>2</sub>), with D<sub>1</sub> forming the focus of the present study. The D<sub>1</sub> deformation is represented by large-scale faults and records two periods of faulting. These periods are recognized as early compressional thrust faulting and a dominant late stage characterized by normal faulting and extension, with the latter stages of D<sub>1</sub> being near-coeval with the emplacement of the Nize granodiorite porphyries. The combination of zircon ages, geochemical data, and structural analysis indicates that the Nize granodiorite porphyries formed after collision of the South Qiangtang and Lhasa terranes. Adakitic magma derived from partial melting of the thickened lower or middle crust resulted from lithospheric delamination that may have been promoted by the convective removal of deeper lithospheric mantle.
DOI: 10.6084/m9.figshare.7974101
title: Pharmacokinetics of oleracimine in rats by ultra-high-performance liquid chromatography

description: The novel alkaloid, oleracimine, presented remarkable anti-inflammatory bioactivity, and therefore, its pharmacokinetics was investigated in rat plasma after intravenous and oral administration by using a rapid ultra-high-performance liquid chromatography (UHPLC) method with UV detection at 270 nm. The analysis was performed on a shim-pack ODS column (75 mm×2 mm, 1.6 µm particle size, Shimadzu, Japan) column using isocratic elution with a mobile phase consisting of methanol-water (62:38, v/v) within 3 min. The results indicated that oleracimine was rapidly distributed with Tmax for 11.7 min after oral administration, which presented the double-peak phenomenon in the pharmacokinetic profile with a higher oral absolute bioavailability of 55.1% ± 7.83%.
DOI: 10.6084/m9.figshare.11901297
title: Additional file 1 of Systemic exosomal miR-193b-3p delivery attenuates neuroinflammation in early brain injury after subarachnoid hemorrhage in mice

description: Additional file 1.
DOI: 10.6084/m9.figshare.7974101.v1
title: Pharmacokinetics of oleracimine in rats by ultra-high-performance liquid chromatography

description: The novel alkaloid, oleracimine, presented remarkable anti-inflammatory bioactivity, and therefore, its pharmacokinetics was investigated in rat plasma after intravenous and oral administration by using a rapid ultra-high-performance liquid chromatography (UHPLC) method with UV detection at 270 nm. The analysis was performed on a shim-pack ODS column (75 mm×2 mm, 1.6 µm particle size, Shimadzu, Japan) column using isocratic elution with a mobile phase consisting of methanol-water (62:38, v/v) within 3 min. The results indicated that oleracimine was rapidly distributed with Tmax for 11.7 min after oral administration, which presented the double-peak phenomenon in the pharmacokinetic profile with a higher oral absolute bioavailability of 55.1% ± 7.83%.
DOI: 10.6084/m9.figshare.24648198
title: Decoupled oxidation process enabled by atomically dispersed copper electrodes for in-situ chemical water treatment

description: data of the figures and calculations involved in the manuscript
DOI: 10.6084/m9.figshare.24648198.v1
title: Decoupled oxidation process enabled by atomically dispersed copper electrodes for in-situ chemical water treatment

description: data of the figures and calculations involved in the manuscript
DOI: 10.6084/m9.figshare.21601442
title: Additional file 9 of Neuronal nuclear calcium signaling suppression of microglial reactivity is mediated by osteoprotegerin after traumatic brain injury

description: Additional file 9: Table S4. Statistical Summary. Full information on statistical analysis for each experiment has been listed.
DOI: 10.6084/m9.figshare.24607668
title: Neural network enabled nanoplasmonic hydrogen sensors with 100 ppm limit of detection in humid air

description: These data constitute the full set of results used to generate the corresponding study.
DOI: 10.6084/m9.figshare.24847581.v1
title: Motility and tumor infiltration are key aspects of invariant natural killer T cell anti-tumor function

description: The source data for "Motility and tumor infiltration are key aspects of invariant natural killer T cell anti-tumor function".
DOI: 10.6084/m9.figshare.7974164.v1
title: Ustekinumab treats psoriasis by suppressing RORC and T-box but its suppression of GATA restrains its efficacy

description: Psoriasis is a T-cell mediated disease that involves IL-23/Th17 and IL-12/Th1 axes. Ustekinumab, a fully human monoclonal antibody targeting the p40 subunit of both IL-12 and IL-23, has proven to be efficient and safe for treating patients with psoriasis. Yet, there have been no reports with human skin/blood samples that would elucidate the molecular mechanisms by which ustekinumab calms psoriasis skin lesions. To investigate the efficacy and molecular pathway (RORC, t-BOX and GATA) of ustekinumab in treating patients with psoriasis skin lesions. A total of 30 patients with psoriasis were randomized into placebo group and treatment group. PASI of each patient was calculated at 0, 12 and 24 weeks post-treatment. The mRNA levels of RORC, t-BOX and GATA in peripheral blood mononuclear cells separated from patients’ whole blood were analyzed using qPCR. Decreased mRNA of RORC, t-BOX and GATA were observed after continuous injections, indicating that ustekinumab exerts its effect by interacting with these molecules; while no significant difference in foxp3 mRNA levels were found between placebo group and treatment group.
DOI: 10.17632/ggywzpf8mf.1
title: Karst Depression Dataset

description: The dataset consists of images and corresponding labels designed to study karst landscapes. Each image in the dataset is a composite patch composed of multiple layers or spectral bands, encapsulating a wealth of geographical and topographical information. These patches have dimensions of 128 pixels by 128 pixels, with each pixel representing a specific area on the ground. The dataset contains a total of 55 spectral bands, organized as follows:

- SRTM (Shuttle Radar Topography Mission) Bands (0-10): These bands are derived from the SRTM mission and provide elevation data, crucial for identifying karst features such as sinkholes and ridges. The SRTM data offers a foundational layer for understanding the surface topography.

- ASTER GDEM (Advanced Spaceborne Thermal Emission and Reflection Radiometer Global Digital Elevation Model) Bands (11-21): These bands offer additional elevation data with a focus on thermal emissions and reflection, which helps in differentiating between various landforms and can be particularly useful in karst terrain analysis.

- AW3D30 (ALOS World 3D - 30m) Bands (22-32): Derived from the ALOS (Advanced Land Observing Satellite), these bands provide high-resolution elevation data, enhancing the detail with which karst features can be identified and analyzed.

- GLO-30 (Global Digital Elevation Model - 30m) Bands (33-43): GLO-30 bands offer a global perspective on elevation, sourced from a compilation of high-resolution satellite images, aiding in a comprehensive understanding of karst landscapes on a broader scale.

- NASADEM (NASA Digital Elevation Model) Bands (44-54): These bands are the latest in elevation modeling from NASA, offering refined elevation data that incorporates data from previous missions like SRTM, but with improved accuracy and resolution.

A label with dimensions of 128x128 accompanies each image patch. These labels are crucial for supervised learning tasks, as they provide the ground truth for the presence or absence of karst features within each patch. The labels are designed to facilitate the training of machine learning models that can automatically detect and classify karst phenomena from the spectral data provided.
DOI: 10.6084/m9.figshare.7974212.v1
title: Swertiamarin attenuates carbon tetrachloride (CCl4)-induced liver injury and inﬂammation in rats by regulating the TLR4 signaling pathway

description: The aim of the present study is to illustrate the effects of swertiamarin (STM), a natural iridoid from herbal medicines, on hepatic inﬂammation induced by carbon tetrachloride (CCl4) in rats. Male Sprague Dawley rats were exposed to CCl4 with or without STM co-administration for 8 weeks. Our results revealed that STM administration (100 and 200 mg/kg b.w.) signiﬁcantly attenuated inflammation in livers of CCl4-treated rats. STM remarkably reduced the production of interleukin-1β (IL-1β), interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-α), macrophage inflammatory protein-1a (MIP-1α), and monocyte chemotactic protein-1 (MCP-1) in liver tissue of CCl4-treated rats. In addition, STM treatment downregulated connective tissue growth factor (CTGF) and ser307pIRS-1 expression, which was induced by CCl4 exposure. In the process of exploring the anti-inflammatory mechanisms of STM action, we demonstrated that STM signiﬁcantly inhibited Toll-like receptor 4 (TLR4) and nuclear factor kappa B (NF-κB) p65 expression in the liver. In conclusion, these results suggested that the inhibition of CCl4-induced inﬂammation by STM was, at least in part, due to its regulation of the TLR4 /NF-κB signaling pathway.
DOI: 10.17632/7wynp4yxkh.1
title: Comparison of twelve sequential online motor assessment of patients with Parkinson disease by multiple raters in different locations

description: Detection of movements in the extremities of people with Parkinson disease was developed to enhance clinical assessments. This data represents the administration of online motor assessments to detect the movements in the extremities of people with Parkinson's disease by examiners certified in the Movement Disorders Society-sponsored revision of the Unified Parkinson’s Disease Rating Scale (MDS-UPDRS) (Goetz, et al., 2008). 


Ten trained raters who were certified in the administration of the Movement Disorders Society-sponsored revision of the Unified Parkinson’s Disease Rating Scale (MDS-UPDRS) (Goetz, et al., 2008) conducted 10 online motor assessments for one patient with Parkinson disease. Each rater utilized a separate computer at different location in three continents. At the beginning of each session the patient was asked for his permission to record the session. Second, the investigator asked the patient about the current medications and weight. Third, the investigator announced each motor assessment by saying the number and the name of each task before conducting the task for all of the raters. Fourth, the investigator gave the patient the specific instructions for each task, demonstrated each task, and asked the participant to begin the task. The investigator didn't continue to demonstrate the task after the participant began the task. For the repetitive items the investigator asked the participant to perform the activities as fully and as fast as possible. After performing each task the raters were given one minute to write their scores. This process was repeated for all of the tasks. At the conclusion of the session the participant was excused after setting the next session date, and then all of the raters shared their scores with the investigator by email. Finally the investigator conducted a consensus conference to attain agreement on each score for each task. 



One expert certified in the MDS-UPDRS (Goetz, et al., 2008) edited the original videotapes to extract only the administration of each task.The videotape segments correspond to the tasks of the protocol (3.17RTU: 3.17 Rest tremor amplitude upper limbs, 3.17RTUC: 3.17 Rest tremor amplitude upper limbs counting, 3.15PT: 3.15 Postural tremor of the hands, 3.4FT: 3.4 Finger tapping, 3.5HM: 3.5 Hand movements, 3.6PS: 3.6 Pronation-supination movements of the hands, 3.9ACU: 3.9 Arising from chair upper limbs).
DOI: 10.6084/m9.figshare.21601436
title: Additional file 7 of Neuronal nuclear calcium signaling suppression of microglial reactivity is mediated by osteoprotegerin after traumatic brain injury

description: Additional file 7: Table S2. Targeted transcriptome analysis reveals new neuronal nuclear calcium-regulated mediators of neuro–glia crosstalk upon TBI. All significantly differentially regulated genes between the PV.NLS TBI (PT) and Control TBI (CT) /PV.NLS Sham (PS) are listed with name, log FC and their adjusted p-value.