cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.5532265
title: Supplementary Material for: Novel Techniques and the Future of Skull Base Reconstruction

description: The field of endoscopic skull base surgery has evolved considerably in recent years fueled largely by advances in both imaging and instrumentation. While the indications for these approaches continue to be extended, the ability to reconstruct the resultant defects has emerged as a rate-limiting obstacle. Postoperative failures with current multilayer grafting techniques remain significant and may increase as the indications for endoscopic resections continue to expand. Laser tissue welding represents a novel method of wound repair in which laser energy is applied to a chromophore doped biologic solder at the wound edge to create a laser weld (fig. 1). These repairs are capable of withstanding forces far exceeding those exerted by intracranial pressure with negligible collateral thermal tissue injury. Recent clinical trials have demonstrated the safety and feasibility of endoscopic laser welding while exposing the limitations of first generation hyaluronic acid based solders. Novel supersaturated gel based solders are currently being tested in clinical trials and appear to possess significantly improved viscoelastic properties. While laser tissue welding remains an experimental technique, continued success with these novel solder formulations may catalyze the widespread adoption of this technique for skull base repair in the near future.
DOI: 10.6084/m9.figshare.5532265.v1
title: Supplementary Material for: Novel Techniques and the Future of Skull Base Reconstruction

description: The field of endoscopic skull base surgery has evolved considerably in recent years fueled largely by advances in both imaging and instrumentation. While the indications for these approaches continue to be extended, the ability to reconstruct the resultant defects has emerged as a rate-limiting obstacle. Postoperative failures with current multilayer grafting techniques remain significant and may increase as the indications for endoscopic resections continue to expand. Laser tissue welding represents a novel method of wound repair in which laser energy is applied to a chromophore doped biologic solder at the wound edge to create a laser weld (fig. 1). These repairs are capable of withstanding forces far exceeding those exerted by intracranial pressure with negligible collateral thermal tissue injury. Recent clinical trials have demonstrated the safety and feasibility of endoscopic laser welding while exposing the limitations of first generation hyaluronic acid based solders. Novel supersaturated gel based solders are currently being tested in clinical trials and appear to possess significantly improved viscoelastic properties. While laser tissue welding remains an experimental technique, continued success with these novel solder formulations may catalyze the widespread adoption of this technique for skull base repair in the near future.
DOI: 10.6084/m9.figshare.5532688.v1
title: Supplementary Material for: Polymorphisms in Sex Hormone Metabolism Genes and Risk of Preeclampsia in Taiyuan, China

description: <i>Objective:</i> Aberrant synthesis and metabolism of sex hormone are likely to be associated with alterations in vascular function in preeclampsia (PE). The study aims to investigate whether single nucleotide polymorphisms (SNPs) in sex hormone-related genes are associated with PE. <i>Method:</i> We performed a nested case-control study including 436 pregnant women (203 PE and 233 healthy or normal pregnant women) to investigate associations between 96 SNPs in 28 sex hormone-related genes and risk of PE. <i>Results:</i><i>TXNRD2/COMT</i> rs3788314 and <i>SULT1A2/SULT1A1 </i>rs4788073 were associated with an increased risk of PE overall (<i>p</i><i>trend</i> = 0.004 and 0.003, respectively), early-onset PE (<i>p</i><i>trend</i> = 0.007 and 0.009, respectively), and severe PE (<i>p</i><i>trend</i> = 0.002 and 0.005, respectively). Additionally, <i>CYP17A1 </i>rs4919690 and rs4919687 and <i>LHCGR rs10180731</i>were associated with an increased risk of severe PE (<i>p</i><i>trend</i> = 0.005, 0.006, and 0.014, respectively), while <i>GNRHR</i> rs2630488 was associated with a decreased risk of severe PE (<i>p</i><i>trend</i> = 0.014). We also observed that <i>HSD17B3</i> rs8190512 was associated with a decreased risk of early-onset PE (<i>p</i><i>trend</i> = 0.003). We observed strong linkage disequilibrium in SULF1 (rs10106958, rs7813987, and rs6990375). <i>Conclusions:</i> Our study suggested that genetic polymorphisms in <i>TXNRD2/COMT, SULT1A2/SULT1A1, CYP17A1, HSD17B3, GNRHR, LHCGR, </i>and SULF1 might play a role in PE, especially in early-onset PE and severe PE. Future studies are warranted to replicate the observed associations and their functional mechanisms.
DOI: 10.6084/m9.figshare.5532412.v2
title: Lepidium didymum raw data from Sperber et al Nature Communications

description: This is the raw data from Sperber et al 2018 (Nature Comms).<br>
DOI: 10.6084/m9.figshare.5532412.v1
title: Ledidium didymum raw data from Sperber et al Nature Communications

description: This is the raw data from Sperber et al 2018 (Nature Comms).<br>
DOI: 10.6084/m9.figshare.5532244
title: All Q-Chem output files and optimised geometries from Correction to ‘A DFT investigation of the blue bottle experiment: <i>E</i><sup>°</sup><sub>halfcell</sub> analysis of autoxidation catalysed by redox indicators’

description: Raw output files and geometries
DOI: 10.6084/m9.figshare.5532241
title: Detailed worksheet for energies and graphs from Correction to ‘A DFT investigation of the blue bottle experiment: <i>E</i><sup>°</sup><sub>halfcell</sub> analysis of autoxidation catalysed by redox indicators’

description: Excel worksheet
DOI: 10.6084/m9.figshare.5532244.v1
title: All Q-Chem output files and optimised geometries from Correction to ‘A DFT investigation of the blue bottle experiment: <i>E</i><sup>°</sup><sub>halfcell</sub> analysis of autoxidation catalysed by redox indicators’

description: Raw output files and geometries
DOI: 10.6084/m9.figshare.5532226
title: QST date.pzfx

description: <sub>Effect of low level laser therapy on tooth-related pain and somatosensory function evoked by orthodontic treatment</sub>
DOI: 10.6084/m9.figshare.5532229
title: Supplementary Material for: Pedicled Extranasal Flaps in Skull Base Reconstruction

description: Cerebrospinal fluid (CSF) leaks most commonly arise during or after skull base surgery, although they occasionally present spontaneously. Recent advances in the repair of CSF leaks have enabled endoscopic endonasal surgery to become the preferred option for management of skull base pathology. Small defects (&lt;1 cm) can be repaired by multilayered free grafts. For large defects (&gt;3 cm), pedicled vascular flaps are the repair method of choice, resulting in much lower rates of postoperative CSF leaks. The pedicled nasoseptal flap (NSF) constitutes the primary reconstructive option for the vast majority of skull base defects. It has a large area of potential coverage and high rates of success. However, preoperative planning is required to avoid sacrificing the NSF during resection. In cases where the NSF is unavailable, often due to tumor involvement of the septum or previous resection removing or compromising the flap, other flaps may be considered. These flaps include intranasal options – inferior turbinate or middle turbinate flaps – as well as regional pedicled flaps: pericranial flap, temporoparietal fascial flap, or palatal flap. More recently, novel alternatives such as the pedicled facial buccinator flap and the pedicled occipital galeopericranial flap have been added to the arsenal of options for skull base reconstruction. Characteristics of and appropriate uses for each flap are described.
DOI: 10.6084/m9.figshare.5532226.v1
title: QST date.pzfx

description: <sub>Effect of low level laser therapy on tooth-related pain and somatosensory function evoked by orthodontic treatment</sub>
DOI: 10.6084/m9.figshare.5532241.v1
title: Detailed worksheet for energies and graphs from Correction to ‘A DFT investigation of the blue bottle experiment: <i>E</i><sup>°</sup><sub>halfcell</sub> analysis of autoxidation catalysed by redox indicators’

description: Excel worksheet
DOI: 10.6084/m9.figshare.5532217
title: Supplementary Material for: Anteriorly Based Pedicled Flaps for Skull Base Reconstruction

description: The expansion of endoscopic skull base surgery has resulted in the creation of large defects that must be repaired to ensure separation of the cranial vault from the nasal cavity. The workhorse of anterior skull base reconstruction remains the nasoseptal or Hadad-Bassagasteguy flap. Despite its success, the nasoseptal flap is limited in its ability to reach extremely anterior defects including those involving the frontal break, posterior frontal table, and anterior cribiform plate. Alternative approaches utilizing anteriorly pedicled flaps have been described which exploit the vascular supply to the anterior septum and lateral nasal wall. The diminutive nature of the anterior septal blood supply has led to the elaboration of a bipedicled anterior septal flap which is capable of reliable reconstruction of both the frontal beak as well as posterior frontal table defects. Similarly anteriorly based inferior turbinate flaps pedicled largely on anterior ethmoid arborizations have been used successfully to reconstruct anterior defects. In light of the limitations of the nasoseptal flap, the addition of anteriorly pedicled flaps to the clinical armamentarium offers the opportunity to provide vascularized mucosal coverage of virtually any region of the skull base which can be reached endoscopically.
DOI: 10.6084/m9.figshare.5532229.v1
title: Supplementary Material for: Pedicled Extranasal Flaps in Skull Base Reconstruction

description: Cerebrospinal fluid (CSF) leaks most commonly arise during or after skull base surgery, although they occasionally present spontaneously. Recent advances in the repair of CSF leaks have enabled endoscopic endonasal surgery to become the preferred option for management of skull base pathology. Small defects (&lt;1 cm) can be repaired by multilayered free grafts. For large defects (&gt;3 cm), pedicled vascular flaps are the repair method of choice, resulting in much lower rates of postoperative CSF leaks. The pedicled nasoseptal flap (NSF) constitutes the primary reconstructive option for the vast majority of skull base defects. It has a large area of potential coverage and high rates of success. However, preoperative planning is required to avoid sacrificing the NSF during resection. In cases where the NSF is unavailable, often due to tumor involvement of the septum or previous resection removing or compromising the flap, other flaps may be considered. These flaps include intranasal options – inferior turbinate or middle turbinate flaps – as well as regional pedicled flaps: pericranial flap, temporoparietal fascial flap, or palatal flap. More recently, novel alternatives such as the pedicled facial buccinator flap and the pedicled occipital galeopericranial flap have been added to the arsenal of options for skull base reconstruction. Characteristics of and appropriate uses for each flap are described.
DOI: 10.6084/m9.figshare.5532214
title: Microsecond-long molecular dynamics trajectory of an aggregate of elastin-like peptides in water

description: This binary file is provided as supplementary material for a research article on the structure and self-assembly of elastin-like peptides (1). It was generated by the molecular dynamics program GROMACS, version 4.6 (2). It contains the last microsecond of a 5-microsecond molecular dynamics trajectory of 27 (GVPGV)<sub>7</sub> peptides in water. See ref. 1 for details.(1) S. Rauscher and R. Pomès. The liquid structure of elastin. eLife, in press (2017). DOI: 10.7554/eLife.26526(2) Hess, B., Kutzner, C., van der Spoel, D. & Lindahl, E. GROMACS 4: Algorithms for Highly Efficient, Load-Balanced, and Scalable Molecular Simulation. <i>J. Chem. Theory Comput.</i> <b>4,</b> 435–447 (2008). DOI: 10.1021/ct700301q
DOI: 10.6084/m9.figshare.5532217.v1
title: Supplementary Material for: Anteriorly Based Pedicled Flaps for Skull Base Reconstruction

description: The expansion of endoscopic skull base surgery has resulted in the creation of large defects that must be repaired to ensure separation of the cranial vault from the nasal cavity. The workhorse of anterior skull base reconstruction remains the nasoseptal or Hadad-Bassagasteguy flap. Despite its success, the nasoseptal flap is limited in its ability to reach extremely anterior defects including those involving the frontal break, posterior frontal table, and anterior cribiform plate. Alternative approaches utilizing anteriorly pedicled flaps have been described which exploit the vascular supply to the anterior septum and lateral nasal wall. The diminutive nature of the anterior septal blood supply has led to the elaboration of a bipedicled anterior septal flap which is capable of reliable reconstruction of both the frontal beak as well as posterior frontal table defects. Similarly anteriorly based inferior turbinate flaps pedicled largely on anterior ethmoid arborizations have been used successfully to reconstruct anterior defects. In light of the limitations of the nasoseptal flap, the addition of anteriorly pedicled flaps to the clinical armamentarium offers the opportunity to provide vascularized mucosal coverage of virtually any region of the skull base which can be reached endoscopically.
DOI: 10.6084/m9.figshare.5532193
title: Table S4 from Genetic architecture and regulatory impact on hepatic microRNA expression linked to immune and metabolic traits

description: Hepatic miRNAs, which correlated with both, blood serum biochemical and haematological traits.
DOI: 10.6084/m9.figshare.5532193.v1
title: Table S4 from Genetic architecture and regulatory impact on hepatic microRNA expression linked to immune and metabolic traits

description: Hepatic miRNAs, which correlated with both, blood serum biochemical and haematological traits.
DOI: 10.6084/m9.figshare.5532169
title: Table S3 from Genetic architecture and regulatory impact on hepatic microRNA expression linked to immune and metabolic traits

description: Correlation coefficients between miRNAs and haematological traits.
DOI: 10.6084/m9.figshare.5532178
title: Table S7 from Genetic architecture and regulatory impact on hepatic microRNA expression linked to immune and metabolic traits

description: Genetic regulation of hepatic miRNA expression (miRNA-eQTL)
DOI: 10.6084/m9.figshare.5532172
title: Supplementary Data from Multi-scale mechanics of granular solids from grain-resolved X-ray measurements

description: Grain positions and stresses, volume-averaged strains, inter-particle forces, and load cell force data, described in more detail in the supplementary text.
DOI: 10.6084/m9.figshare.5532169.v1
title: Table S3 from Genetic architecture and regulatory impact on hepatic microRNA expression linked to immune and metabolic traits

description: Correlation coefficients between miRNAs and haematological traits.
DOI: 10.6084/m9.figshare.5532172.v1
title: Supplementary Data from Multi-scale mechanics of granular solids from grain-resolved X-ray measurements

description: Grain positions and stresses, volume-averaged strains, inter-particle forces, and load cell force data, described in more detail in the supplementary text.
DOI: 10.6084/m9.figshare.5532178.v1
title: Table S7 from Genetic architecture and regulatory impact on hepatic microRNA expression linked to immune and metabolic traits

description: Genetic regulation of hepatic miRNA expression (miRNA-eQTL)
DOI: 10.6084/m9.figshare.5532151
title: Table S6 from Genetic architecture and regulatory impact on hepatic microRNA expression linked to immune and metabolic traits

description: Correlations between miRNAs, mRNAs and haematological traits (mRNAs listed are predicted as targets and are negatively correlated to miRNA), (miRNA and mRNA are also correlated with the same phenotypes)
DOI: 10.6084/m9.figshare.5532148
title: Supporting file 3 from Beyond cancer genes: colorectal cancer as robust intrinsic states formed by molecular interactions

description: Hypothesis testing and details for figure 5.
DOI: 10.6084/m9.figshare.5532151.v1
title: Table S6 from Genetic architecture and regulatory impact on hepatic microRNA expression linked to immune and metabolic traits

description: Correlations between miRNAs, mRNAs and haematological traits (mRNAs listed are predicted as targets and are negatively correlated to miRNA), (miRNA and mRNA are also correlated with the same phenotypes)
DOI: 10.6084/m9.figshare.5532148.v1
title: Supporting file 3 from Beyond cancer genes: colorectal cancer as robust intrinsic states formed by molecular interactions

description: Hypothesis testing and details for figure 5.
DOI: 10.6084/m9.figshare.5532133
title: Table S5 from Genetic architecture and regulatory impact on hepatic microRNA expression linked to immune and metabolic traits

description: Correlations between miRNAs, mRNAs and biochemical traits (mRNAs listed are predicted as targets and are negatively correlated to miRNA), (miRNA and mRNA were also correlated with the same phenotypes)
DOI: 10.6084/m9.figshare.5532127
title: Supporting file 1 from Beyond cancer genes: colorectal cancer as robust intrinsic states formed by molecular interactions

description: Details and references for figure 4.
DOI: 10.6084/m9.figshare.5532133.v1
title: Table S5 from Genetic architecture and regulatory impact on hepatic microRNA expression linked to immune and metabolic traits

description: Correlations between miRNAs, mRNAs and biochemical traits (mRNAs listed are predicted as targets and are negatively correlated to miRNA), (miRNA and mRNA were also correlated with the same phenotypes)
DOI: 10.6084/m9.figshare.5532118
title: Toy Train from Toy trains, loaded dice and the origin of life: dimerization on mineral surfaces under thermochemical-pH periodic drive with Gaussian inputs

description: XPPAUT code for equations 2.1-2.3
DOI: 10.6084/m9.figshare.5532127.v1
title: Supporting file 1 from Beyond cancer genes: colorectal cancer as robust intrinsic states formed by molecular interactions

description: Details and references for figure 4.
DOI: 10.6084/m9.figshare.5532109
title: Table S8 from Genetic architecture and regulatory impact on hepatic microRNA expression linked to immune and metabolic traits

description: Common SNPs which regulated both mRNA and miRNA and correlated with biochemical or haematological traits.
DOI: 10.6084/m9.figshare.5532118.v1
title: Toy Train from Toy trains, loaded dice and the origin of life: dimerization on mineral surfaces under thermochemical-pH periodic drive with Gaussian inputs

description: XPPAUT code for equations 2.1-2.3
DOI: 10.6084/m9.figshare.5532109.v1
title: Table S8 from Genetic architecture and regulatory impact on hepatic microRNA expression linked to immune and metabolic traits

description: Common SNPs which regulated both mRNA and miRNA and correlated with biochemical or haematological traits.
DOI: 10.6084/m9.figshare.5532088
title: Figures 3 and 4 data from Toy trains, loaded dice and the origin of life: dimerization on mineral surfaces under thermochemical-pH periodic drive with Gaussian inputs

description: Raw data for figures 3 and 4
DOI: 10.6084/m9.figshare.5532088.v1
title: Figures 3 and 4 data from Toy trains, loaded dice and the origin of life: dimerization on mineral surfaces under thermochemical-pH periodic drive with Gaussian inputs

description: Raw data for figures 3 and 4
DOI: 10.6084/m9.figshare.5532058
title: Supporting file 2 from Beyond cancer genes: colorectal cancer as robust intrinsic states formed by molecular interactions

description: Original microarray data.
DOI: 10.6084/m9.figshare.5532055
title: Figure 5 data from Toy trains, loaded dice and the origin of life: dimerization on mineral surfaces under thermochemical-pH periodic drive with Gaussian inputs

description: Raw data for Figure 5
DOI: 10.6084/m9.figshare.5532058.v1
title: Supporting file 2 from Beyond cancer genes: colorectal cancer as robust intrinsic states formed by molecular interactions

description: Original microarray data.
DOI: 10.6084/m9.figshare.5532052
title: Table S2 from Genetic architecture and regulatory impact on hepatic microRNA expression linked to immune and metabolic traits

description: Correlation coefficients between miRNAs and biochemical traits.
DOI: 10.6084/m9.figshare.5532055.v1
title: Figure 5 data from Toy trains, loaded dice and the origin of life: dimerization on mineral surfaces under thermochemical-pH periodic drive with Gaussian inputs

description: Raw data for Figure 5
DOI: 10.6084/m9.figshare.5532043
title: Data from Exploring the role of competition induced by non-vaccine serotypes for herd protection following pneumococcal vaccination

description: The data corresponding to Figures 1-4
DOI: 10.6084/m9.figshare.5532052.v1
title: Table S2 from Genetic architecture and regulatory impact on hepatic microRNA expression linked to immune and metabolic traits

description: Correlation coefficients between miRNAs and biochemical traits.
DOI: 10.6084/m9.figshare.5532043.v1
title: Data from Exploring the role of competition induced by non-vaccine serotypes for herd protection following pneumococcal vaccination

description: The data corresponding to Figures 1-4
DOI: 10.6084/m9.figshare.5532034
title: Supplementary Material for: Sphenopalatine-Derived Pedicled Flaps

description: A variety of local flaps based on the sphenopalatine artery are available for endoscopic skull base reconstruction including the nasoseptal flap, middle turbinate flap, and posteriorly based inferior turbinate flap. This section will describe the alternatives to the nasoseptal flap, emphasizing the relevant anatomy, indications and technical aspects involved with their use.
DOI: 10.6084/m9.figshare.5532007
title: Data to accompany "Maintenance of muscle strength retains a normal metabolic cost in simulated walking after below-knee limb loss"

description: Data to accompany "Maintenance of muscle strength retains a normal metabolic cost in simulated walking after below-knee limb loss"<br>The files included are:<br>(1) Matlab script (LoadAndPlotData.m) for loading and plotting the data<br>(2) Matlab datafiles (Y_S[id]_[condition].mat) for individual subject results(3) Matlab scripts (ModPars_S[id].m) with the model parameter values for each subject(4) Matlab datafiles (Ytar.mat, Yw.mat) for the referenced experimental data (Miller et al., 2014)<br>
DOI: 10.6084/m9.figshare.5532034.v1
title: Supplementary Material for: Sphenopalatine-Derived Pedicled Flaps

description: A variety of local flaps based on the sphenopalatine artery are available for endoscopic skull base reconstruction including the nasoseptal flap, middle turbinate flap, and posteriorly based inferior turbinate flap. This section will describe the alternatives to the nasoseptal flap, emphasizing the relevant anatomy, indications and technical aspects involved with their use.
DOI: 10.6084/m9.figshare.5532007.v1
title: Data to accompany "Maintenance of muscle strength retains a normal metabolic cost in simulated walking after below-knee limb loss"

description: Data to accompany "Maintenance of muscle strength retains a normal metabolic cost in simulated walking after below-knee limb loss"<br>The files included are:<br>(1) Matlab script (LoadAndPlotData.m) for loading and plotting the data<br>(2) Matlab datafiles (Y_S[id]_[condition].mat) for individual subject results(3) Matlab scripts (ModPars_S[id].m) with the model parameter values for each subject(4) Matlab datafiles (Ytar.mat, Yw.mat) for the referenced experimental data (Miller et al., 2014)<br>