cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.28103565
title: Existence and significance of anti-HLA-C autoantibodies to primary and persistent platelet transfusion refractoriness in patients with hematologic disorders: a retrospective study from a single centre

description: Platelet transfusion refractoriness (PTR) is a frustrating clinical problem, and primary and persistent (P/P) PTR who experienced persistent PTR since the first transfusion was failed to be well recognized. This study aims to investigate the incidence and risk factors for P/P PTR. Patients with hematologic disorders who underwent HLA high-resolution genotyping and donor-specific HLA antibody or panel reactive antibody (PRA) testing between January 2019 and March 2023 were reviewed. Clinical data including infection history, splenomegaly, frequency and quantity of blood transfusions, and transfusions response were delineated and subsequently analyzed. 114 patients were included retrospectively, and 1071 transfusions were recorded. The overall incidence of PTR was 28.95% (33/114), with 63.63% (21/33) being P/P PTR. Anti class I HLA (anti-HLA-I) antibody was identified as an independent risk factor for ineffective platelet transfusion through multivariate logistic regression analysis (<i>p</i> = .034). Interestingly, anti-HLA-C autoantibodies were first found in six patients, and both anti-HLA-A and C autoantibodies were detected in one case, comprising a total of 10.71% (6/56) of HLA-I antibody-positive patients. Further analysis revealed that anti-HLA-C autoantibody was identified as an independent risk factor for P/P PTR (<i>p</i> = .039). Among patients with positive anti-HLA-C antibodies, significant differences in the effectiveness of ABO, D-matched and cross-matching transfusions were observed between patients with or without anti-HLA-C autoantibodies (<i>p</i> &lt; .001 and <i>p</i> = .017). Notably, platelet transfusions independence was achieved by two of the four patients who received rituximab. This work emphasized the significance of anti-HLA-C autoantibody for P/P PTR in hematological patients, and rituximab may therapeutic. 28.95% who experienced platelet transfusion refractoriness (PTR), 23 were primary and persistent (P/P) PTRAnti-HLA-C autoantibody was identified as an independent risk factor for P/P PTRApplication of rituximab may practical in the management of P/P PTR with HLA-C autoantibodies 28.95% who experienced platelet transfusion refractoriness (PTR), 23 were primary and persistent (P/P) PTR Anti-HLA-C autoantibody was identified as an independent risk factor for P/P PTR Application of rituximab may practical in the management of P/P PTR with HLA-C autoantibodies
DOI: 10.6084/m9.figshare.28103565.v1
title: Existence and significance of anti-HLA-C autoantibodies to primary and persistent platelet transfusion refractoriness in patients with hematologic disorders: a retrospective study from a single centre

description: Platelet transfusion refractoriness (PTR) is a frustrating clinical problem, and primary and persistent (P/P) PTR who experienced persistent PTR since the first transfusion was failed to be well recognized. This study aims to investigate the incidence and risk factors for P/P PTR. Patients with hematologic disorders who underwent HLA high-resolution genotyping and donor-specific HLA antibody or panel reactive antibody (PRA) testing between January 2019 and March 2023 were reviewed. Clinical data including infection history, splenomegaly, frequency and quantity of blood transfusions, and transfusions response were delineated and subsequently analyzed. 114 patients were included retrospectively, and 1071 transfusions were recorded. The overall incidence of PTR was 28.95% (33/114), with 63.63% (21/33) being P/P PTR. Anti class I HLA (anti-HLA-I) antibody was identified as an independent risk factor for ineffective platelet transfusion through multivariate logistic regression analysis (<i>p</i> = .034). Interestingly, anti-HLA-C autoantibodies were first found in six patients, and both anti-HLA-A and C autoantibodies were detected in one case, comprising a total of 10.71% (6/56) of HLA-I antibody-positive patients. Further analysis revealed that anti-HLA-C autoantibody was identified as an independent risk factor for P/P PTR (<i>p</i> = .039). Among patients with positive anti-HLA-C antibodies, significant differences in the effectiveness of ABO, D-matched and cross-matching transfusions were observed between patients with or without anti-HLA-C autoantibodies (<i>p</i> &lt; .001 and <i>p</i> = .017). Notably, platelet transfusions independence was achieved by two of the four patients who received rituximab. This work emphasized the significance of anti-HLA-C autoantibody for P/P PTR in hematological patients, and rituximab may therapeutic. 28.95% who experienced platelet transfusion refractoriness (PTR), 23 were primary and persistent (P/P) PTRAnti-HLA-C autoantibody was identified as an independent risk factor for P/P PTRApplication of rituximab may practical in the management of P/P PTR with HLA-C autoantibodies 28.95% who experienced platelet transfusion refractoriness (PTR), 23 were primary and persistent (P/P) PTR Anti-HLA-C autoantibody was identified as an independent risk factor for P/P PTR Application of rituximab may practical in the management of P/P PTR with HLA-C autoantibodies
DOI: 10.6084/m9.figshare.29528759
title: Effect of general anesthesia on postoperative pulmonary embolism

description: The influence of anesthesia type and duration on the occurrence of pulmonary embolism (PE) after surgery remains controversial. This study investigates the association between anesthesia type and duration with postoperative PE. A retrospective cohort of adult patients undergoing surgery from May 2020 to August 2024 at large-scale general hospitals was analyzed. Multivariable logistic regression models were employed to adjust for potential confounders, and sensitivity analyses (using overlap weighting and array approach) were performed to validate the findings. A total of 178,052 patients were included in the analysis, of whom 91 developed PE after surgery. The median duration of general anesthesia (GA) was 1.72 h, with an interquartile range (IQR) of 1.17–2.52 h. The median duration of regional anesthesia was 1.54 h, with an IQR of 1.20–2.03 h. Anesthesia type and the duration of regional anesthesia were not associated with PE occurrence (adjusted odds ratio [aOR] [95% confidence interval, CI], 1.148 [0.671–2.098], <i>p</i> = 0.631), (aOR [95% CI], 1.117 [0.498–1.557], <i>p</i> = 0.738). The rates of PE consistently increased with GA prolongation (aOR [95% CI], 1.308 [1.176–1.432], <i>p</i> &lt; 0.001). Compared with GA durations &lt; 3 h, prolonged anesthesia was significantly associated with increased PE incidence (aOR [95% CI], 4.398 [2.585–7.565], <i>p</i> &lt; 0.001). These findings were also confirmed by sensitivity analyses. Our study demonstrates that prolonged GA, particularly &gt; 3 h, significantly increases the risk of PE.
DOI: 10.6084/m9.figshare.29528759.v1
title: Effect of general anesthesia on postoperative pulmonary embolism

description: The influence of anesthesia type and duration on the occurrence of pulmonary embolism (PE) after surgery remains controversial. This study investigates the association between anesthesia type and duration with postoperative PE. A retrospective cohort of adult patients undergoing surgery from May 2020 to August 2024 at large-scale general hospitals was analyzed. Multivariable logistic regression models were employed to adjust for potential confounders, and sensitivity analyses (using overlap weighting and array approach) were performed to validate the findings. A total of 178,052 patients were included in the analysis, of whom 91 developed PE after surgery. The median duration of general anesthesia (GA) was 1.72 h, with an interquartile range (IQR) of 1.17–2.52 h. The median duration of regional anesthesia was 1.54 h, with an IQR of 1.20–2.03 h. Anesthesia type and the duration of regional anesthesia were not associated with PE occurrence (adjusted odds ratio [aOR] [95% confidence interval, CI], 1.148 [0.671–2.098], <i>p</i> = 0.631), (aOR [95% CI], 1.117 [0.498–1.557], <i>p</i> = 0.738). The rates of PE consistently increased with GA prolongation (aOR [95% CI], 1.308 [1.176–1.432], <i>p</i> &lt; 0.001). Compared with GA durations &lt; 3 h, prolonged anesthesia was significantly associated with increased PE incidence (aOR [95% CI], 4.398 [2.585–7.565], <i>p</i> &lt; 0.001). These findings were also confirmed by sensitivity analyses. Our study demonstrates that prolonged GA, particularly &gt; 3 h, significantly increases the risk of PE.
DOI: 10.6084/m9.figshare.28553881
title: Sustainability in food-based dietary guidelines: a review of recommendations around meat and dairy consumption and their visual representation

description: The transition away from high meat and dairy consumption and towards more plant-based diets is vital for environmental sustainability targets, including reducing greenhouse gas (GHG) emissions and land use associated with food. Food-based dietary guidelines (FBDG) communicate nutrition information to a country’s general public. However, it is unknown how different countries’ FBDG communicate reducing meat and dairy intake in the context of sustainability. To address this gap, we reviewed global consumer-facing FBDG (<i>n</i> = 58) in middle- and high-income countries to examine recommendations and information around meat and dairy consumption, and to explore the pictorial representation of these foods. Few countries used a sustainability argument to recommend reducing meat (6/58) or dairy consumption (2/58). The proportion of dairy images within food guides was consistently higher than meat images. Some countries’ guidelines are starting to consider meat intake in the context of sustainability and implementing meat reduction recommendations. However, this is not the case for dairy, potentially due to complex nutritional implications. Overall, our review shows that very few countries recommend reducing either meat or dairy consumption. To reduce the environmental impact of food systems, clearer guidelines backed by current evidence are needed, which provide justification behind recommendations, actionable advice for how to meet the recommendations, and appropriate quantified food targets or limits. This well-rounded advice is imperative to empower citizens to take action on their dietary habits, to reduce global meat and dairy consumption and replace these with more sustainable alternatives for human and planetary health.
DOI: 10.6084/m9.figshare.28553881.v1
title: Sustainability in food-based dietary guidelines: a review of recommendations around meat and dairy consumption and their visual representation

description: The transition away from high meat and dairy consumption and towards more plant-based diets is vital for environmental sustainability targets, including reducing greenhouse gas (GHG) emissions and land use associated with food. Food-based dietary guidelines (FBDG) communicate nutrition information to a country’s general public. However, it is unknown how different countries’ FBDG communicate reducing meat and dairy intake in the context of sustainability. To address this gap, we reviewed global consumer-facing FBDG (<i>n</i> = 58) in middle- and high-income countries to examine recommendations and information around meat and dairy consumption, and to explore the pictorial representation of these foods. Few countries used a sustainability argument to recommend reducing meat (6/58) or dairy consumption (2/58). The proportion of dairy images within food guides was consistently higher than meat images. Some countries’ guidelines are starting to consider meat intake in the context of sustainability and implementing meat reduction recommendations. However, this is not the case for dairy, potentially due to complex nutritional implications. Overall, our review shows that very few countries recommend reducing either meat or dairy consumption. To reduce the environmental impact of food systems, clearer guidelines backed by current evidence are needed, which provide justification behind recommendations, actionable advice for how to meet the recommendations, and appropriate quantified food targets or limits. This well-rounded advice is imperative to empower citizens to take action on their dietary habits, to reduce global meat and dairy consumption and replace these with more sustainable alternatives for human and planetary health.
DOI: 10.6084/m9.figshare.30411461
title: Clinical and laboratory predictors of mortality in <i>Staphylococcus aureus</i> bacteremia in a high-risk setting: a single-center retrospective analysis of Pitt score, SOFA, neutrophil-to-lymphocyte ratio, and platelet-to-lymphocyte ratio

description: <i>Staphylococcus aureus</i> bacteremia (SAB) is associated with significant morbidity and mortality despite advancements in antimicrobial therapies. Timely risk stratification is critical to optimize patient outcomes. This study aimed to evaluate the prognostic value of clinical (Pitt bacteremia score [PBS]), combined clinical and laboratory (Sequential Organ Failure Assessment [SOFA]), and laboratory-based parameters (neutrophil-to-lymphocyte ratio [NLR] and platelet-to-lymphocyte ratio [PLR]) in patients with SAB. We conducted a retrospective observational study of 150 adult patients diagnosed with monomicrobial SAB between November 2023 and November 2024 at a tertiary care center. The predictive value of PBS, SOFA, NLR, and PLR for in-hospital mortality was assessed using ROC analysis and logistic regression. The overall in-hospital mortality rate was 46%. PBS &gt;4 and NLR &gt;21 were independently associated with increased mortality (OR 11.72 and 6.36, respectively; <i>p</i> &lt; 0.001). Absence of fever (OR 0.11) and presence of central venous catheter (OR 4.11) were also significant predictors. ROC analysis demonstrated good predictive performance for both PBS (AUC: 0.82) and SOFA (AUC: 0.795) scores with no statistically significant difference between them. Community-acquired SAB and primary bacteremia were associated with worse prognosis. Methicillin resistance did not significantly affect mortality. Fever response was significantly blunted in older adults but not in immunosuppressed patients. High PBS and NLR are strong and independent predictors of mortality in SAB. As this study was conducted in a high-risk cohort with a considerable proportion of critically ill and immunocompromised patients, the findings are particularly relevant to this vulnerable population. External validation in larger, multicenter cohorts is required to confirm their generalizability.
DOI: 10.6084/m9.figshare.30411461.v1
title: Clinical and laboratory predictors of mortality in <i>Staphylococcus aureus</i> bacteremia in a high-risk setting: a single-center retrospective analysis of Pitt score, SOFA, neutrophil-to-lymphocyte ratio, and platelet-to-lymphocyte ratio

description: <i>Staphylococcus aureus</i> bacteremia (SAB) is associated with significant morbidity and mortality despite advancements in antimicrobial therapies. Timely risk stratification is critical to optimize patient outcomes. This study aimed to evaluate the prognostic value of clinical (Pitt bacteremia score [PBS]), combined clinical and laboratory (Sequential Organ Failure Assessment [SOFA]), and laboratory-based parameters (neutrophil-to-lymphocyte ratio [NLR] and platelet-to-lymphocyte ratio [PLR]) in patients with SAB. We conducted a retrospective observational study of 150 adult patients diagnosed with monomicrobial SAB between November 2023 and November 2024 at a tertiary care center. The predictive value of PBS, SOFA, NLR, and PLR for in-hospital mortality was assessed using ROC analysis and logistic regression. The overall in-hospital mortality rate was 46%. PBS &gt;4 and NLR &gt;21 were independently associated with increased mortality (OR 11.72 and 6.36, respectively; <i>p</i> &lt; 0.001). Absence of fever (OR 0.11) and presence of central venous catheter (OR 4.11) were also significant predictors. ROC analysis demonstrated good predictive performance for both PBS (AUC: 0.82) and SOFA (AUC: 0.795) scores with no statistically significant difference between them. Community-acquired SAB and primary bacteremia were associated with worse prognosis. Methicillin resistance did not significantly affect mortality. Fever response was significantly blunted in older adults but not in immunosuppressed patients. High PBS and NLR are strong and independent predictors of mortality in SAB. As this study was conducted in a high-risk cohort with a considerable proportion of critically ill and immunocompromised patients, the findings are particularly relevant to this vulnerable population. External validation in larger, multicenter cohorts is required to confirm their generalizability.
DOI: 10.6084/m9.figshare.29648777
title: Dual-approach analysis of gut microbiome in patients with type 1 diabetes and diabetic kidney disease

description: Type 1 diabetes (T1D) is a multifactorial autoimmune disease mediated by genetic, epigenetic, and environmental factors. Diabetic kidney disease (DKD) is a major complication of diabetes mellitus which affects 30–40% of T1D patients. Increasing evidence suggests the significant role of the microbiome in the progression of both T1D and DKD. Here we recruited 76 T1D patients and 22 healthy controls and combined data from sigmoid colon biopsy samples analysed with V3–V4 region amplification of 16S rRNA gene and shotgun metagenomics data obtained from faecal samples. Additionally, we compared T1D patients with and without progression of DKD. We observed significant differences within both sample types at various taxonomic and functional levels. T1D patient microbiota detected using biopsy samples had a lower abundance of the <i>Bacteroides</i> genus when compared to healthy controls. Significantly, despite only a few taxonomic differences patients with and without DKD progression were vastly different at the functional pathway level within the faecal samples - we observed 2 and 61 enriched pathways in these groups. respectively, with several of these pathways linked to the mediation of renal function. Altogether, we present novel data about microbial signatures relevant to T1D and DKD progression, which partly supports previous data and also presents possible tissue type or population-specific elements. DKD progression is characterized with significant differences within the functional level of the gut microbiome.
DOI: 10.6084/m9.figshare.29648777.v1
title: Dual-approach analysis of gut microbiome in patients with type 1 diabetes and diabetic kidney disease

description: Type 1 diabetes (T1D) is a multifactorial autoimmune disease mediated by genetic, epigenetic, and environmental factors. Diabetic kidney disease (DKD) is a major complication of diabetes mellitus which affects 30–40% of T1D patients. Increasing evidence suggests the significant role of the microbiome in the progression of both T1D and DKD. Here we recruited 76 T1D patients and 22 healthy controls and combined data from sigmoid colon biopsy samples analysed with V3–V4 region amplification of 16S rRNA gene and shotgun metagenomics data obtained from faecal samples. Additionally, we compared T1D patients with and without progression of DKD. We observed significant differences within both sample types at various taxonomic and functional levels. T1D patient microbiota detected using biopsy samples had a lower abundance of the <i>Bacteroides</i> genus when compared to healthy controls. Significantly, despite only a few taxonomic differences patients with and without DKD progression were vastly different at the functional pathway level within the faecal samples - we observed 2 and 61 enriched pathways in these groups. respectively, with several of these pathways linked to the mediation of renal function. Altogether, we present novel data about microbial signatures relevant to T1D and DKD progression, which partly supports previous data and also presents possible tissue type or population-specific elements. DKD progression is characterized with significant differences within the functional level of the gut microbiome.
DOI: 10.6084/m9.figshare.29257370
title: Comparing efficacy of different scoring models to predict hepatic encephalopathy after TIPS in cirrhotic patients

description: Assessing hepatic encephalopathy (HE) risk post-transjugular intrahepatic portosystemic shunt (TIPS) in cirrhotic patients is crucial. This study compares the predictive performance of Child-Pugh and Model for End-Stage Liver Disease (MELD), CLIFC-AD and Freiburg index of post-TIPS survival (FIPS) scores for overt and severe HE. To compare the predictive value of Child-Pugh, MELD, CLIFC-AD and FIPS scores for overt and severe HE post-TIPS in cirrhotic patients. We retrospectively analysed data from 406 cirrhotic TIPS patients (January 2017–January 2021). Scoring models were assessed for differentiation (C-index), calibration, clinical utility and overall performance at 1, 3, 6 and 12 months post-TIPS. Predictive performance for overt HE post-TIPS was low across models. FIPS had superior predictive ability for severe HE at 1 and 12 months post-TIPS (C-index: 0.781, 0.705). FIPS and CLIFC-AD showed good predictive capacity for severe HE in sarcopenic patients at 1 and 12 months (FIPS: C-index 0.863, 0.757; CLIFC-AD: C-index 0.748, 0.732). FIPS had the highest hazard ratio for severe HE (HR = 3.520, 95% CI: 2.134–5.807) and CLIFC-AD for overt HE (HR = 2.132, 95% CI: 1.581–2.874). FIPS and CLIFC-AD scores demonstrate significant predictive ability for severe HE post-TIPS, particularly in sarcopenic patients. The study compares Child-Pugh, MELD, CLIFC-AD and FIPS scores for predicting hepatic encephalopathy post-TIPS.FIPS excels in predicting post-TIPS severe hepatic encephalopathy.FIPS and CLIFC-AD scores effectively predict severe hepatic encephalopathy in sarcopenic patients. The study compares Child-Pugh, MELD, CLIFC-AD and FIPS scores for predicting hepatic encephalopathy post-TIPS. FIPS excels in predicting post-TIPS severe hepatic encephalopathy. FIPS and CLIFC-AD scores effectively predict severe hepatic encephalopathy in sarcopenic patients.