cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.26799135.v1
title: Transcriptome analyses reveal key features of mouse seminal vesicle during aging

description: Despite the significant morphological changes that occur in the seminal vesicles with aging, the transcriptomic characteristics remain largely unexplored. To address this, we performed bulk RNA sequencing on seminal vesicle samples from mice aged 3, 13, and 21 months to uncover transcriptomic alterations. Our findings reveal that aged seminal vesicles display cystic dilatation, epithelial hypoplasia, disordered muscle layers, fibrosis, and reduced proliferation capability. A comparison between 3-month-old and 21-month-old mice indicated that leukocyte-mediated immunity and leukocyte migration were the most significantly upregulated biological processes among differentially expressed genes (DEGs). Notably, several DEGs associated with "leukocyte migration," such as <i>Vcam1</i>, <i>Cxcl13</i>, and <i>Ccl8</i>, exhibited an increasing trend in transcriptomic and protein expression at three different time points in the seminal vesicles of mice. Additionally, we identified multiple aging-associated DEGs, including <i>P21</i> and <i>Tnfrsf1b</i>. Two genes (<i>Cd209f</i> and <i>Ccl8</i>) were consistently upregulated across all six regions of the male reproductive glands (testis, epididymis, and seminal vesicle) in the comparison of bulk RNA datasets from 3-month-old and 21-month-old mice. These analyses highlight an enhanced state of immune and inflammatory response in aged seminal vesicles. This study represents the first exploration of the overall transcriptome landscape of seminal vesicles in a murine model of natural aging, offering new insights into the mechanisms underlying aging-related seminal vesicle dysfunction.
DOI: 10.6084/m9.figshare.25627876
title: Prediction of deleterious non-synonymous SNPs of human MDC1 gene: an in silico approach

description: MDC1 (Mediator of DNA damage Checkpoint protein 1) functions to facilitate the localization of numerous DNA damage response (DDR) components to DNA double-strand break sites. MDC1 is an integral component in preserving genomic stability and appropriate DDR regulation. There haven’t been systematic investigations of MDC1 mutations that induce cancer and genomic instability. Variations in nsSNPs have the potential to modify the protein chemistry and their function. Describing functional SNPs in disease-associated genes presents a significant conundrum for investigators, it is possible to assess potential functional SNPs before conducting larger population examinations. Multiple sequences and structure-based bioinformatics strategies were implemented in the current in-silico investigation to discern potential nsSNPs of the MDC1 genes. The nsSNPs were identified with SIFT, SNAP2, Align GVGD, PolyPhen-2, and PANTHER, and their stability was determined with MUpro. The conservation, solvent accessibility, and structural effects of the mutations were identified with ConSurf, NetSurfP-2.0, and SAAFEC-SEQ respectively. Cancer-related analysis of the nsSNPs was conducted using cBioPortal and TCGA web servers. The present study appraised five nsSNPs (P1426T, P69S, P194R, P203L, and H131Y) as probably mutilating due to their existence in highly conserved regions and propensity to deplete protein stability. The nsSNPs P194R, P203L, and H131Y were concluded as deleterious and possibly damaging from the 5 prediction tools. The functional nsSNP P194R mutation is associated with skin cutaneous melanoma while no significant records were found for other nsSNPs. The present study concludes that the highly deleterious P194R mutations can potentially induce genomic instability and contribute to various cancers’ pathogenesis. Developing drugs targeting these mutations can undoubtedly be advantageous in large population-based studies, particularly in the development of precision medicine.
DOI: 10.6084/m9.figshare.25627876.v1
title: Prediction of deleterious non-synonymous SNPs of human MDC1 gene: an in silico approach

description: MDC1 (Mediator of DNA damage Checkpoint protein 1) functions to facilitate the localization of numerous DNA damage response (DDR) components to DNA double-strand break sites. MDC1 is an integral component in preserving genomic stability and appropriate DDR regulation. There haven’t been systematic investigations of MDC1 mutations that induce cancer and genomic instability. Variations in nsSNPs have the potential to modify the protein chemistry and their function. Describing functional SNPs in disease-associated genes presents a significant conundrum for investigators, it is possible to assess potential functional SNPs before conducting larger population examinations. Multiple sequences and structure-based bioinformatics strategies were implemented in the current in-silico investigation to discern potential nsSNPs of the MDC1 genes. The nsSNPs were identified with SIFT, SNAP2, Align GVGD, PolyPhen-2, and PANTHER, and their stability was determined with MUpro. The conservation, solvent accessibility, and structural effects of the mutations were identified with ConSurf, NetSurfP-2.0, and SAAFEC-SEQ respectively. Cancer-related analysis of the nsSNPs was conducted using cBioPortal and TCGA web servers. The present study appraised five nsSNPs (P1426T, P69S, P194R, P203L, and H131Y) as probably mutilating due to their existence in highly conserved regions and propensity to deplete protein stability. The nsSNPs P194R, P203L, and H131Y were concluded as deleterious and possibly damaging from the 5 prediction tools. The functional nsSNP P194R mutation is associated with skin cutaneous melanoma while no significant records were found for other nsSNPs. The present study concludes that the highly deleterious P194R mutations can potentially induce genomic instability and contribute to various cancers’ pathogenesis. Developing drugs targeting these mutations can undoubtedly be advantageous in large population-based studies, particularly in the development of precision medicine.
DOI: 10.6084/m9.figshare.26110707
title: piRNA expression patterns in high vs. low fertility bovine sperm

description: PIWI-interacting RNAs (piRNAs) are 24–32 nucleotide RNA sequences primarily expressed in germ cells and developing embryos that suppress transposable element expression to protect genomic integrity during epigenetic reprogramming events. We characterized the expression of piRNA sequences and their encoding clusters in sperm samples from an idiopathic fertility model of Holstein bulls with high and low Sire Conception Rates. The piRNA populations were determined to be mostly similar between fertility conditions when investigated by principal component and differential expression analysis, suggesting that a high degree of conservation in the piRNA system is likely necessary for the production of viable sperm. Both fertility conditions demonstrated evidence of ‘ping-pong’ activity – a secondary biogenesis pathway associated with active transposable element targeting and suppression. Most sperm-borne piRNAs were between 29-30 nucleotides in length and originated from 226 clusters across the genome, with the exception of chromosome 20. Mapping analysis revealed abundant targeting of several transposable element families, suggesting a suppressive function of sperm piRNAs consistent with their established roles. Expression of genes targeted by sperm-borne piRNAs is significantly reduced throughout early embryogenesis compared to the mRNA population. Limited transposable element expression is known to be essential for spermatogenesis, thus epigenetic regulation of this pathway is likely to influence sperm quality and fertilizing capacity.
DOI: 10.6084/m9.figshare.26110707.v1
title: piRNA expression patterns in high vs. low fertility bovine sperm

description: PIWI-interacting RNAs (piRNAs) are 24–32 nucleotide RNA sequences primarily expressed in germ cells and developing embryos that suppress transposable element expression to protect genomic integrity during epigenetic reprogramming events. We characterized the expression of piRNA sequences and their encoding clusters in sperm samples from an idiopathic fertility model of Holstein bulls with high and low Sire Conception Rates. The piRNA populations were determined to be mostly similar between fertility conditions when investigated by principal component and differential expression analysis, suggesting that a high degree of conservation in the piRNA system is likely necessary for the production of viable sperm. Both fertility conditions demonstrated evidence of ‘ping-pong’ activity – a secondary biogenesis pathway associated with active transposable element targeting and suppression. Most sperm-borne piRNAs were between 29-30 nucleotides in length and originated from 226 clusters across the genome, with the exception of chromosome 20. Mapping analysis revealed abundant targeting of several transposable element families, suggesting a suppressive function of sperm piRNAs consistent with their established roles. Expression of genes targeted by sperm-borne piRNAs is significantly reduced throughout early embryogenesis compared to the mRNA population. Limited transposable element expression is known to be essential for spermatogenesis, thus epigenetic regulation of this pathway is likely to influence sperm quality and fertilizing capacity.
DOI: 10.15468/dl.m84f45
title: Occurrence Download

description: A dataset containing 3 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Rastrelliger faughni Matsui, 1967",
 "Geometry POLYGON((170 20, 170 50, 120 50, 120 20, 170 20))",
 "HasCoordinate is true"
 ]
}

 The dataset includes 3 records from 3 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0001584-250127130748423/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.5683/sp3/8kbiav
title: Enquête canadienne sur le tabac et la nicotine 2021
title: Enquête canadienne sur le tabac et la nicotine
title: ECTN 2021
title: Canadian Tobacco and Nicotine Survey, 2021

description: &lt;p&gt;Les renseignements recueillis dans le cadre de cette enquête serviront à combler d'importantes lacunes en matière de données sur le vapotage et sur l'usage du cannabis et du tabac. Les données contribueront à l'élaboration de politiques et fourniront un portrait de la consommation partout au Canada.&lt;/p&gt; &lt;p&gt;Jusqu'en 2017, Statistique Canada menait l'Enquête canadienne sur le tabac, l'alcool et les drogues (ECTAD). Cette enquête permettait de recueillir des données sur le tabac ainsi que sur l'alcool et les drogues. En 2019, l'Enquête canadienne sur l'alcool et les drogues (ECAD) a été menée afin de collecter des données sur l'alcool et les drogues indépendamment de l'Enquête canadienne sur le tabac et la nicotine (ECTN) qui a été menée principalement afin de collecter des données sur le tabac et la nicotine.&lt;/p&gt;
description: Enquête canadienne sur le tabac et la nicotine
description: Migration from Nesstar, null
DOI: 10.15468/dl.8sgk5f
title: Occurrence Download

description: A dataset containing 142 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is Austria",
 "TaxonKey is Dendrobaena octaedra (Savigny, 1826)"
 ]
}

 The dataset includes 142 records from 5 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0001585-250127130748423/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.5281/zenodo.11217909
title: Mobile comparison data and analysis between a new low-cost meteorological device and the Technical University of Dresden Chair of Meteorology's backpack meteorological device

description: This dataset provides mobile comparison data from Tharandt and Dresden, Germany, which was used to demontrate the suitability of a new low-cost and user-friendly meteorological device for the purpose of thermal comfort mapping. The new device was compared to an established high-end backpack-mounted device from the Dresden University of Technology (TUD) Chair of Meteorology, Germany. The main sensors for comparison were: the low-cost SHT 85 Sensirion sensor vs. the high-cost WXT520 for air temperature and relative humdity and the low-cost SR2AD pyranometer vs. the high-cost SKS 1110 pyranometer. The ability of each device to predict the Universal Thermal Climate Index (UTCI), calculated using the software RayMan Pro, was also compared.
DOI: 10.15468/dl.8fbaff
title: Occurrence Download

description: A dataset containing 213 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Phoca largha Pallas, 1811",
 "Geometry POLYGON((170 20, 170 50, 120 50, 120 20, 170 20))",
 "HasCoordinate is true"
 ]
}

 The dataset includes 213 records from 8 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0001587-250127130748423/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.25345/c5w669m73
title: MassIVE MSV000096978 - GNPS Spirostanols of Costus speciosus FBMN analysis from geographical location A
title: GNPS analysis of Costus speciosus extract from geographical location A
DOI: 10.5281/zenodo.10340570
title: Stationary comparison data and analysis between a new low-cost meteorological device and the Technical University of Dresden Chair of Meteorology's backpack meteorological device

description: This dataset provides stationary comparison data which was used to demontrate the suitability of a new low-cost and user-friendly meteorological device for the purpose of thermal comfort mapping. The new device was compared to an established high-end backpack-mounted device from the Dresden University of Technology (TUD) Chair of Meteorology, Germany. The main sensors for comparison were: the low-cost SHT 85 Sensirion sensor vs. the high-cost WXT520 for air temperature and relative humdity and the low-cost SR2AD pyranometer vs. the high-cost SKS 1110 pyranometer.
DOI: 10.15468/dl.uyzxek
title: Occurrence Download

description: A dataset containing 214927 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Callinectes sapidus Rathbun, 1896"
 ]
}

 The dataset includes 214927 records from 164 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0001565-250127130748423/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.5281/zenodo.14748897
title: Sea temperature, Dissolved oxygen, Chlorophyll-a from the E1 buoy at the LTER site Delta del Po and Costa Romagnola (2012-2022)

description: The present dataset comprises observations spanning from 2012 to 2022, focusing on parameters collected from the E1 meteo-oceanographic buoy in the Northern Adriatic Sea (north of Rimini city on a bottom depth of 10.5 m), Italy. Specifically, it encompasses measurements taken in the water column at a defined depth (URI: https://vocab.nerc.ac.uk/collection/P01/current/ADEPZZ01/) of Sea temperature with SBE37 (URI: http://vocab.nerc.ac.uk/collection/OD1/current/SEATEMP/) in degC (Degrees Celsius; URI: http://vocab.nerc.ac.uk/collection/P06/current/UPAA/), Dissolved Oxygen concentrations with SBE63 (URI:                   http://vocab.nerc.ac.uk/collection/P35/current/EPC00002/) in mg/l (Milligrams per litre, URI: http://vocab.nerc.ac.uk/collection/P06/current/UMGL/), and Chlorophyll-a concentration (URI:       http://vocab.nerc.ac.uk/collection/R03/current/CHLA/, estimates from in situ chlorophyll fluorometer) in mg/m^3 (Milligrams per cubic meter; URI: http://vocab.nerc.ac.uk/collection/P06/current/UMMC/) by WETLabs ECO Triplet (URI: http://vocab.nerc.ac.uk/collection/L22/current/TOOL0674/2/, three-optical-sensor instrument). The buoy is located at 44,14° N; 12,57° E (WGS-84 coordinate system) and is managed by the Institute of Marine Science of the National Research Council (ISMAR-CNR) in Bologna. The dataset relies on a Comma Separated Values (CSV) file and it is composed by 91164 records, offering an invaluable insight into the dynamic characteristics of the marine environment in this area over nearly a decade. The E1 buoy is part of the site “Delta del Po and Costa Romagnola”, which belongs to the Long Term Ecological Research national and international networks (LTER-Italy, LTER-Europe and ILTER) and eLTER-RI.
DOI: 10.5281/zenodo.14748898
title: Sea temperature, Dissolved oxygen, Chlorophyll-a from the E1 buoy at the LTER site Delta del Po and Costa Romagnola (2012-2022)

description: The present dataset comprises observations spanning from 2012 to 2022, focusing on parameters collected from the E1 meteo-oceanographic buoy in the Northern Adriatic Sea (north of Rimini city on a bottom depth of 10.5 m), Italy. Specifically, it encompasses measurements taken in the water column at a defined depth (URI: https://vocab.nerc.ac.uk/collection/P01/current/ADEPZZ01/) of Sea temperature with SBE37 (URI: http://vocab.nerc.ac.uk/collection/OD1/current/SEATEMP/) in degC (Degrees Celsius; URI: http://vocab.nerc.ac.uk/collection/P06/current/UPAA/), Dissolved Oxygen concentrations with SBE63 (URI:                   http://vocab.nerc.ac.uk/collection/P35/current/EPC00002/) in mg/l (Milligrams per litre, URI: http://vocab.nerc.ac.uk/collection/P06/current/UMGL/), and Chlorophyll-a concentration (URI:       http://vocab.nerc.ac.uk/collection/R03/current/CHLA/, estimates from in situ chlorophyll fluorometer) in mg/m^3 (Milligrams per cubic meter; URI: http://vocab.nerc.ac.uk/collection/P06/current/UMMC/) by WETLabs ECO Triplet (URI: http://vocab.nerc.ac.uk/collection/L22/current/TOOL0674/2/, three-optical-sensor instrument). The buoy is located at 44,14° N; 12,57° E (WGS-84 coordinate system) and is managed by the Institute of Marine Science of the National Research Council (ISMAR-CNR) in Bologna. The dataset relies on a Comma Separated Values (CSV) file and it is composed by 91164 records, offering an invaluable insight into the dynamic characteristics of the marine environment in this area over nearly a decade. The E1 buoy is part of the site “Delta del Po and Costa Romagnola”, which belongs to the Long Term Ecological Research national and international networks (LTER-Italy, LTER-Europe and ILTER) and eLTER-RI.
DOI: 10.15468/dl.2gm4gh
title: Occurrence Download

description: A dataset containing 480 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Okamejei kenojei (Müller & Henle, 1841)",
 "Geometry POLYGON((170 20, 170 50, 120 50, 120 20, 170 20))",
 "HasCoordinate is true"
 ]
}

 The dataset includes 480 records from 24 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0001589-250127130748423/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.4722rn
title: Occurrence Download

description: A dataset containing 13955 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is Denmark",
 "Month is December",
 "TaxonKey is Fungi",
 "Year 2020-2024"
 ]
}

 The dataset includes 13955 records from 7 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0011973-241024112534372/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.48597/t6ub-xxct
title: Precipitation_amount_off at Koksijde

description: Measurement of Precipitation_amount_off at Koksijde
DOI: 10.48597/3udt-hd8w
title: Measurement of Precipitation_amount_off at Koksijde

description: Measurement of Precipitation_amount_off at Koksijde
DOI: 10.48597/cxvd-hmgn
title: Measurement of Inorganics in precipitation at Koksijde

description: Measurement of Inorganics in precipitation at Koksijde
DOI: 10.48597/xy2c-q2zc
title: Measurement of Inorganics in precipitation at Koksijde

description: Measurement of Inorganics in precipitation at Koksijde
DOI: 10.18150/zxlinp
title: Novel adducts of acyclovir with 2,6-dihydroxybenzoic acid

description: Cocrystallization experiments of acyclovir (ACV) using 2,6-dihydroxybenzoic acid (26DHBA) as a coformer were performed. Two new ionic ACV-26DHBA complexes were obtained. Salts were obtained not only by cocrystallization from the solution. The above systems were obtained by milling and cocrystallization from suspension with, and without microwave radiation. The new adducts were characterized using X-ray diffraction. The deposited CIF files include crystallographic information regarding the single-crystal X-ray data collection and the crystal structures of the obtained adducts. The analysis of the arrangement of molecules in the crystal lattice through a series of hydrogen bonds was performed using the Mercury program.
DOI: 10.15468/dl.gt4gn8
title: Occurrence Download

description: A dataset containing 577020 species occurrences available in GBIF matching the query:
{
 "and" : [
 "BasisOfRecord is Specimen",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 "TaxonKey is Melastomataceae"
 ]
}

 The dataset includes 577020 records from 632 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0011972-241024112534372/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.34740/kaggle/dsv/9762579
title: Daily Public Opinion on Israel-Palestine War
DOI: 10.48597/88p6-h4as
title: Inorganics in precipitation at Koksijde

description: Measurement of Inorganics in precipitation at Koksijde
DOI: 10.48597/j3y9-wpqr
title: Pm10_mass at Bukit Kototabang

description: Measurement of Pm10_mass at Bukit Kototabang
DOI: 10.48597/e2p9-fzrs
title: Measurement of Inorganics in precipitation at Koksijde

description: Measurement of Inorganics in precipitation at Koksijde
DOI: 10.48597/gnqm-wf5y
title: Measurement of Pm10_mass at Bukit Kototabang

description: Measurement of Pm10_mass at Bukit Kototabang
DOI: 10.48597/n599-tdk8
title: Measurement of Pm10_mass at Bukit Kototabang

description: Measurement of Pm10_mass at Bukit Kototabang
DOI: 10.48597/pe9c-rrb6
title: Measurement of Inorganics in precipitation at Koksijde

description: Measurement of Inorganics in precipitation at Koksijde
DOI: 10.21227/3vas-r509
title: Numerical Assessment of Radiator, Floor, and Ceiling Heaters

description: Numerical simulations are used to assess the efficiency of floor heating, ceiling heating, and plane radiator heating in a selected family house room under winter conditions in the Central European climate zone. COMSOL Multiphysics software was used for computer simulations. The output data were subsequently processed and analyzed using MATLAB software. Results indicate that floor and ceiling heating systems achieve higher and more rapid temperature increases compared to plane radiators. The distribution of air temperature within the room was also analyzed, revealing that floor heating provides the most uniform temperature distribution. These findings contribute to developing effective heating strategies for residential buildings in similar climatic conditions. Furthermore, appropriate processing of output data obtained from computer simulations using artificial intelligence tools contributes to increasing the accuracy and efficiency of numerical analysis methods.