cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.5517/ccdc.csd.cc23k5rm
title: CCDC 1952930: Experimental Crystal Structure Determination

description: Related Article: Qin Ai Wong, Ching Kheng Quah, Xin Ai Wong, Yip-Foo Win, Huey Chong Kwong, Parutagouda Shankaragouda Patil, Neelamma B. Gummagol, S. Venugopal Rao|2022|Phys.Chem.Chem.Phys.(PCCP)|24|21927|doi:10.1039/D2CP02127G
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc23k5sn
title: CCDC 1952931: Experimental Crystal Structure Determination

description: Related Article: Qin Ai Wong, Ching Kheng Quah, Xin Ai Wong, Yip-Foo Win, Huey Chong Kwong, Parutagouda Shankaragouda Patil, Neelamma B. Gummagol, S. Venugopal Rao|2022|Phys.Chem.Chem.Phys.(PCCP)|24|21927|doi:10.1039/D2CP02127G
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2bbbst
title: CCDC 2154896: Experimental Crystal Structure Determination

description: Related Article: Ramadoss Govindarajan, Shubham Deolka, Eugene Khaskin, Robert R. Fayzullin, Shrinwantu Pal, Serhii Vasylevskyi, Julia R. Khusnutdinova|2022|Chem.-Eur.J.|28|e202201639|doi:10.1002/chem.202201639
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2bbbvw
title: CCDC 2154898: Experimental Crystal Structure Determination

description: Related Article: Ramadoss Govindarajan, Shubham Deolka, Eugene Khaskin, Robert R. Fayzullin, Shrinwantu Pal, Serhii Vasylevskyi, Julia R. Khusnutdinova|2022|Chem.-Eur.J.|28|e202201639|doi:10.1002/chem.202201639
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2bbbwx
title: CCDC 2154899: Experimental Crystal Structure Determination

description: Related Article: Ramadoss Govindarajan, Shubham Deolka, Eugene Khaskin, Robert R. Fayzullin, Shrinwantu Pal, Serhii Vasylevskyi, Julia R. Khusnutdinova|2022|Chem.-Eur.J.|28|e202201639|doi:10.1002/chem.202201639
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2bbbxy
title: CCDC 2154900: Experimental Crystal Structure Determination

description: Related Article: Ramadoss Govindarajan, Shubham Deolka, Eugene Khaskin, Robert R. Fayzullin, Shrinwantu Pal, Serhii Vasylevskyi, Julia R. Khusnutdinova|2022|Chem.-Eur.J.|28|e202201639|doi:10.1002/chem.202201639
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2bbbyz
title: CCDC 2154901: Experimental Crystal Structure Determination

description: Related Article: Ramadoss Govindarajan, Shubham Deolka, Eugene Khaskin, Robert R. Fayzullin, Shrinwantu Pal, Serhii Vasylevskyi, Julia R. Khusnutdinova|2022|Chem.-Eur.J.|28|e202201639|doi:10.1002/chem.202201639
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2bbbz0
title: CCDC 2154902: Experimental Crystal Structure Determination

description: Related Article: Ramadoss Govindarajan, Shubham Deolka, Eugene Khaskin, Robert R. Fayzullin, Shrinwantu Pal, Serhii Vasylevskyi, Julia R. Khusnutdinova|2022|Chem.-Eur.J.|28|e202201639|doi:10.1002/chem.202201639
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2bbbtv
title: CCDC 2154897: Experimental Crystal Structure Determination

description: Related Article: Ramadoss Govindarajan, Shubham Deolka, Eugene Khaskin, Robert R. Fayzullin, Shrinwantu Pal, Serhii Vasylevskyi, Julia R. Khusnutdinova|2022|Chem.-Eur.J.|28|e202201639|doi:10.1002/chem.202201639
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2bt65k
title: CCDC 2169168: Experimental Crystal Structure Determination

description: Related Article: Ramadoss Govindarajan, Shubham Deolka, Eugene Khaskin, Robert R. Fayzullin, Shrinwantu Pal, Serhii Vasylevskyi, Julia R. Khusnutdinova|2022|Chem.-Eur.J.|28|e202201639|doi:10.1002/chem.202201639
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2cn4gn
title: CCDC 2194101: Experimental Crystal Structure Determination

description: Related Article: R. Alan Aitken, Joe S. Logan, Alexandra M. Z. Slawin|2022|Molbank|2022|M1445|doi:10.3390/M1445
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2cn4hp
title: CCDC 2194102: Experimental Crystal Structure Determination

description: Related Article: R. Alan Aitken, Joe S. Logan, Alexandra M. Z. Slawin|2022|Molbank|2022|M1445|doi:10.3390/M1445
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2cn4jq
title: CCDC 2194103: Experimental Crystal Structure Determination

description: Related Article: R. Alan Aitken, Joe S. Logan, Alexandra M. Z. Slawin|2022|Molbank|2022|M1445|doi:10.3390/M1445
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.20372/nadre/20604
title: Ethiopian Socio Economic Survey Agriculture Post Planting Crop Cut and Livestock Questionnaire - Dataset

description: Ethiopian Socio Economic Survey Agriculture Post Planting Crop Cut and Livestock Questionnaire - Dataset
DOI: 10.20372/nadre/20605
title: Ethiopian Socio Economic Survey Agriculture Post Planting Crop Cut and Livestock Questionnaire - Dataset

description: Ethiopian Socio Economic Survey Agriculture Post Planting Crop Cut and Livestock Questionnaire - Dataset
DOI: 10.5517/ccdc.csd.cc2d2wx9
title: CCDC 2207321: Experimental Crystal Structure Determination

description: Related Article: Lloyd F. Mackenzie, Geoffrey Earl F. Raymond, Harwig Curtis, Ana Fernández Casares|2018|U.S.Patents|||
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.11588/data/bguokj/o0uahm
title: Datenrepositorium DCO Terenz.zip

description: :unav
DOI: 10.11588/data/bguokj/fbhvvr
title: readme.md

description: :unav
DOI: 10.20372/nadre/20523
title: Ethiopian Socio Economic Survey Household Questionnaire - Dataset

description: Ethiopian Socioeconomic Survey Wave 4 Household Questionnaire - Dataset
DOI: 10.20372/nadre/20522
title: Ethiopian Socio Economic Survey Household Questionnaire - Dataset

description: Ethiopian Socioeconomic Survey Wave 4 Household Questionnaire - Dataset
DOI: 10.6084/m9.figshare.19879864
title: Data from: Population demography maintains biogeographic boundaries

description: Data from: Population demography maintains biogeographic boundaries (2022) Ecology Letters 25(8) https://onlinelibrary.wiley.com/doi/epdf/10.1111/ele.14058 <br> Associated code is available on github: https://github.com/chloewsch/genetics_biogeographic_regions
DOI: 10.6084/m9.figshare.19879864.v1
title: Data from: Population demography maintains biogeographic boundaries

description: Data from: Population demography maintains biogeographic boundaries <br> Associated code is available on github: https://github.com/chloewsch/genetics_biogeographic_regions
DOI: 10.5281/zenodo.7129165
title: Code and data for results and figures of the manuscript "Multi-million year cycles in modelled δ13C as a response to astronomical forcing of organic matter fluxes." submitted to Earth System Dynamics

description: This dataset contains the code of the model used in the manuscript submitted to Earth System Dynamics "Multi-million year cycles in modelled δ13C as a response to astronomical forcing of organic matter fluxes.". It also contains some model outputs and code to draw the figures.
DOI: 10.5281/zenodo.7129059
title: Three-color whole cell LLSM imaging data of ER, H2B, and Mito over 1000 time points during mitosis (H2B channel)

description: This dataset includes the three-color whole cell lattice light-sheet microscopy (LLSM) data of ER, H2B, and Mitochondia over 1000 time points at 6 sec intervals in a HeLa cell stably expressing calnexin-mEmerald, H2B-mCherry and Mito-Halo during mitosis (only H2B channel here due to the file size restriction, other channels can be found in the same depository with different DOI), which was used to demonstrate SiS-rDL denoising algorithm in our Nature Biotechnology paper (DOI: 10.1038/s41587-022-01471-3). This dataset can be used for non-commercial purposes with proper citations of our NBT paper.
DOI: 10.5281/zenodo.7129058
title: Three-color whole cell LLSM imaging data of ER, H2B, and Mito over 1000 time points during mitosis (H2B channel)

description: This dataset includes the three-color whole cell lattice light-sheet microscopy (LLSM) data of ER, H2B, and Mitochondia over 1000 time points at 6 sec intervals in a HeLa cell stably expressing calnexin-mEmerald, H2B-mCherry and Mito-Halo during mitosis (only H2B channel here due to the file size restriction, other channels can be found in the same depository with different DOI), which was used to demonstrate SiS-rDL denoising algorithm in our Nature Biotechnology paper (DOI: 10.1038/s41587-022-01471-3). This dataset can be used for non-commercial purposes with proper citations of our NBT paper.
DOI: 10.6084/m9.figshare.20222891
title: Spermidine overrides INSR (insulin receptor)-IGF1R (insulin-like growth factor 1 receptor)-mediated inhibition of autophagy in the aging heart

description: Although attenuated IGF1R (insulin-like growth factor 1 receptor) signaling has long been viewed to promote longevity in model organisms, adverse effects on the heart have been the subject of major concern. We observed that IGF1R is overexpressed in cardiac tissues from patients with end-stage non-ischemic heart failure, coupled to the activation of the IGF1R downstream effector AKT/protein kinase B and inhibition of ULK1 (unc-51 like autophagy activating kinase 1). Transgenic overexpression of human IGF1R in cardiomyocytes from mice initially induces physiological cardiac hypertrophy and superior function, but later in life confers a negative impact on cardiac health, causing macroautophagy/autophagy inhibition as well as impaired oxidative phosphorylation, thus reducing life expectancy. Treatment with the autophagy inducer and caloric restriction mimetic spermidine ameliorates most of these IGF1R-induced cardiotoxic effects in vivo. Moreover, inhibition of IGF1R signaling by means of a dominant-negative phosphoinositide 3-kinase (PI3K) mutant induces cardioprotective autophagy, restores myocardial bioenergetics and improves late-life survival. Hence, our results demonstrate that IGF1R exerts a dual biphasic impact on cardiac health, and that autophagy mediates the late-life geroprotective effects of IGF1R inhibition in the heart.
DOI: 10.6084/m9.figshare.17702968
title: Simultaneous loss of TSC1 and DEPDC5 in skeletal and cardiac muscles produces early-onset myopathy and cardiac dysfunction associated with oxidative damage and SQSTM1/p62 accumulation

description: By promoting anabolism, MTORC1 is critical for muscle growth and maintenance. However, genetic MTORC1 upregulation promotes muscle aging and produces age-associated myopathy. Whether MTORC1 activation is sufficient to produce myopathy or indirectly promotes it by accelerating tissue aging is elusive. Here we examined the effects of muscular MTORC1 hyperactivation, produced by simultaneous depletion of TSC1 and DEPDC5 (CKM-TD). CKM-TD mice produced myopathy, associated with loss of skeletal muscle mass and force, as well as cardiac failure and bradypnea. These pathologies were manifested at eight weeks of age, leading to a highly penetrant fatality at around twelve weeks of age. Transcriptome analysis indicated that genes mediating proteasomal and macroautophagic/autophagic pathways were highly upregulated in CKM-TD skeletal muscle, in addition to inflammation, oxidative stress, and DNA damage signaling pathways. In CKM-TD muscle, autophagosome levels were increased, and the AMPK and ULK1 pathways were activated; in addition, autophagy induction was not completely blocked in CKM-TD myotubes. Despite the upregulation of autolysosomal markers, CKM-TD myofibers exhibited accumulation of autophagy substrates, such as SQSTM1/p62 and ubiquitinated proteins, suggesting that the autophagic activities were insufficient. Administration of a superoxide scavenger, tempol, normalized most of these molecular pathologies and subsequently restored muscle histology and force generation. However, CKM-TD autophagy alterations were not normalized by rapamycin or tempol, suggesting that they may involve non-canonical targets other than MTORC1. These results collectively indicate that the concomitant muscle deficiency of TSC1 and DEPDC5 can produce early-onset myopathy through accumulation of oxidative stress, which dysregulates myocellular homeostasis. <b>Abbreviations:</b> AMPK: AMP-activated protein kinase; CKM: creatine kinase, M-type; COX: cytochrome oxidase; DEPDC5: DEP domain containing 5, GATOR1 subcomplex subunit; DHE: dihydroethidium; EDL: extensor digitorum longus; EIF4EBP1: eukaryotic translation initiation factor 4E binding protein 1; GAP: GTPase-activating protein; GTN: gastrocnemius; MTORC1: mechanistic target of rapamycin kinase complex 1; PLA: plantaris; QUAD: quadriceps; RPS6KB/S6K: ribosomal protein S6 kinase beta; SDH: succinate dehydrogenase; SOL: soleus; SQSTM1: sequestosome 1; TA: tibialis anterior; TSC1: TSC complex subunit 1; ULK1: unc-51 like autophagy activating kinase 1
DOI: 10.6084/m9.figshare.17702968.v1
title: Simultaneous loss of TSC1 and DEPDC5 in skeletal and cardiac muscles produces early-onset myopathy and cardiac dysfunction associated with oxidative damage and SQSTM1/p62 accumulation

description: By promoting anabolism, MTORC1 is critical for muscle growth and maintenance. However, genetic MTORC1 upregulation promotes muscle aging and produces age-associated myopathy. Whether MTORC1 activation is sufficient to produce myopathy or indirectly promotes it by accelerating tissue aging is elusive. Here we examined the effects of muscular MTORC1 hyperactivation, produced by simultaneous depletion of TSC1 and DEPDC5 (CKM-TD). CKM-TD mice produced myopathy, associated with loss of skeletal muscle mass and force, as well as cardiac failure and bradypnea. These pathologies were manifested at eight weeks of age, leading to a highly penetrant fatality at around twelve weeks of age. Transcriptome analysis indicated that genes mediating proteasomal and macroautophagic/autophagic pathways were highly upregulated in CKM-TD skeletal muscle, in addition to inflammation, oxidative stress, and DNA damage signaling pathways. In CKM-TD muscle, autophagosome levels were increased, and the AMPK and ULK1 pathways were activated; in addition, autophagy induction was not completely blocked in CKM-TD myotubes. Despite the upregulation of autolysosomal markers, CKM-TD myofibers exhibited accumulation of autophagy substrates, such as SQSTM1/p62 and ubiquitinated proteins, suggesting that the autophagic activities were insufficient. Administration of a superoxide scavenger, tempol, normalized most of these molecular pathologies and subsequently restored muscle histology and force generation. However, CKM-TD autophagy alterations were not normalized by rapamycin or tempol, suggesting that they may involve non-canonical targets other than MTORC1. These results collectively indicate that the concomitant muscle deficiency of TSC1 and DEPDC5 can produce early-onset myopathy through accumulation of oxidative stress, which dysregulates myocellular homeostasis. <b>Abbreviations:</b> AMPK: AMP-activated protein kinase; CKM: creatine kinase, M-type; COX: cytochrome oxidase; DEPDC5: DEP domain containing 5, GATOR1 subcomplex subunit; DHE: dihydroethidium; EDL: extensor digitorum longus; EIF4EBP1: eukaryotic translation initiation factor 4E binding protein 1; GAP: GTPase-activating protein; GTN: gastrocnemius; MTORC1: mechanistic target of rapamycin kinase complex 1; PLA: plantaris; QUAD: quadriceps; RPS6KB/S6K: ribosomal protein S6 kinase beta; SDH: succinate dehydrogenase; SOL: soleus; SQSTM1: sequestosome 1; TA: tibialis anterior; TSC1: TSC complex subunit 1; ULK1: unc-51 like autophagy activating kinase 1
DOI: 10.6084/m9.figshare.19525068
title: Lamp1 mediates lipid transport, but is dispensable for autophagy in <i>Drosophila</i>

description: The endolysosomal system not only is an integral part of the cellular catabolic machinery that processes and recycles nutrients for synthesis of biomaterials, but also acts as signaling hub to sense and coordinate the energy state of cells with growth and differentiation. Lysosomal dysfunction adversely influences vesicular transport-dependent macromolecular degradation and thus causes serious problems for human health. In mammalian cells, loss of the lysosome associated membrane proteins LAMP1 and LAMP2 strongly affects autophagy and cholesterol trafficking. Here we show that the previously uncharacterized <i>Drosophila</i> Lamp1 is a <i>bona fide</i> ortholog of vertebrate LAMP1 and LAMP2. Surprisingly and in contrast to <i>lamp1 lamp2</i> double-mutant mice, <i>Drosophila</i> Lamp1 is not required for viability or autophagy, suggesting that fly and vertebrate LAMP proteins acquired distinct functions, or that autophagy defects in <i>lamp1 lamp2</i> mutants may have indirect causes. However, Lamp1 deficiency results in an increase in the number of acidic organelles in flies. Furthermore, we find that <i>Lamp1</i> mutant larvae have defects in lipid metabolism as they show elevated levels of sterols and diacylglycerols (DAGs). Because DAGs are the main lipid species used for transport through the hemolymph (blood) in insects, our results indicate broader functions of Lamp1 in lipid transport. Our findings make <i>Drosophila</i> an ideal model to study the role of LAMP proteins in lipid assimilation without the confounding effects of their storage and without interfering with autophagic processes. <b>Abbreviations</b>: aa: amino acid; AL: autolysosome; AP: autophagosome; APGL: autophagolysosome; AV: autophagic vacuole (i.e. AP and APGL/AL); AVi: early/initial autophagic vacuoles; AVd: late/degradative autophagic vacuoles; <i>Atg</i>: autophagy-related; CMA: chaperone-mediated autophagy; Cnx99A: Calnexin 99A; DAG: diacylglycerol; eMI: endosomal microautophagy; ESCRT: endosomal sorting complexes required for transport; FB: fat body; HDL: high-density lipoprotein; Hrs: Hepatocyte growth factor regulated tyrosine kinase substrate; LAMP: lysosomal associated membrane protein; LD: lipid droplet; LDL: low-density lipoprotein; Lpp: lipophorin; LTP: Lipid transfer particle; LTR: LysoTracker Red; MA: macroautophagy; MCC: Manders colocalization coefficient; MEF: mouse embryonic fibroblast MTORC: mechanistic target of rapamycin kinase complex; PV: parasitophorous vacuole; SNARE: soluble N-ethylmaleimide sensitive factor attachment protein receptor; Snap: Synaptosomal-associated protein; st: starved; TAG: triacylglycerol; TEM: transmission electron microscopy; TFEB/Mitf: transcription factor EB; TM: transmembrane domain; tub: tubulin; UTR: untranslated region.