cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.31239385
title: Supplementary Material for: ANGPTL3 in podocytes contributes to the pathogenesis of lupus nephritis by activating MSR1 in macrophages

description: Introduction: Lupus nephritis (LN), a severe complication of systemic lupus erythematosus (SLE), is characterized by persistent immune dysregulation and glomerular injury predominantly driven by macrophage infiltration and type I interferon (IFN‑I) signaling. Crosstalk between injured podocytes and infiltrating macrophages is increasingly recognized as a key contributor to LN progression, however, the molecular mediators and their corresponding receptors remain poorly defined. This study investigates whether ANGPTL3 upregulation in podocytes activates macrophages through MSR1 and drives interferon-biased inflammation in LN. Methods: We employed secretome-based protein–protein interaction screening to identify ANGPTL3 receptors. The ANGPTL3–MSR1 interaction was supported by co-immunoprecipitation. In vitro, bone marrow–derived macrophages (BMDMs) were stimulated with ANGPTL3-conditioned media, and gene expression was analyzed by RNA sequencing. MSR1 was silenced using siRNA. In vivo, a pristane-induced lupus mouse model was used to assess glomerular ANGPTL3/MSR1 expression, renal function, and macrophage infiltration. Clinical relevance was assessed using Nephroseq datasets and human LN kidney specimens. Results: ANGPTL3 was identified as an MSR1-interacting ligand through a cell-based membrane protein screening assay and further supported by co-immunoprecipitation. In vitro, ANGPTL3-conditioned media induced an interferon-dominant transcriptional response in BMDMs, including upregulation of Tnip3 and Isg20. These effects were attenuated upon MSR1 silencing, confirming receptor-dependent activation. Notably, ANGPTL3 had minimal effect on M1/M2 polarization markers, indicating selective regulation of interferon signaling. Analysis of Nephroseq datasets and LN biopsies demonstrated elevated ANGPTL3 and MSR1 expression, which correlated with histopathological severity. Single-cell RNA-seq confirmed MSR1 enrichment in glomerular macrophages. In vivo, pristane-induced lupus mice exhibited increased glomerular ANGPTL3, Synaptopodin loss, proteinuria, and co-localization of F4/80 and MSR1, supporting a pathogenic podocyte–macrophage axis. Conclusion: This study identifies the ANGPTL3-MSR1 axis as a critical pathway linking podocyte injury to macrophage-driven inflammation in LN, highlighting its therapeutic potential. Targeting this axis may disrupt maladaptive immune crosstalk, offering a novel strategy for LN management.
DOI: 10.6084/m9.figshare.31239385.v1
title: Supplementary Material for: ANGPTL3 in podocytes contributes to the pathogenesis of lupus nephritis by activating MSR1 in macrophages

description: Introduction: Lupus nephritis (LN), a severe complication of systemic lupus erythematosus (SLE), is characterized by persistent immune dysregulation and glomerular injury predominantly driven by macrophage infiltration and type I interferon (IFN‑I) signaling. Crosstalk between injured podocytes and infiltrating macrophages is increasingly recognized as a key contributor to LN progression, however, the molecular mediators and their corresponding receptors remain poorly defined. This study investigates whether ANGPTL3 upregulation in podocytes activates macrophages through MSR1 and drives interferon-biased inflammation in LN. Methods: We employed secretome-based protein–protein interaction screening to identify ANGPTL3 receptors. The ANGPTL3–MSR1 interaction was supported by co-immunoprecipitation. In vitro, bone marrow–derived macrophages (BMDMs) were stimulated with ANGPTL3-conditioned media, and gene expression was analyzed by RNA sequencing. MSR1 was silenced using siRNA. In vivo, a pristane-induced lupus mouse model was used to assess glomerular ANGPTL3/MSR1 expression, renal function, and macrophage infiltration. Clinical relevance was assessed using Nephroseq datasets and human LN kidney specimens. Results: ANGPTL3 was identified as an MSR1-interacting ligand through a cell-based membrane protein screening assay and further supported by co-immunoprecipitation. In vitro, ANGPTL3-conditioned media induced an interferon-dominant transcriptional response in BMDMs, including upregulation of Tnip3 and Isg20. These effects were attenuated upon MSR1 silencing, confirming receptor-dependent activation. Notably, ANGPTL3 had minimal effect on M1/M2 polarization markers, indicating selective regulation of interferon signaling. Analysis of Nephroseq datasets and LN biopsies demonstrated elevated ANGPTL3 and MSR1 expression, which correlated with histopathological severity. Single-cell RNA-seq confirmed MSR1 enrichment in glomerular macrophages. In vivo, pristane-induced lupus mice exhibited increased glomerular ANGPTL3, Synaptopodin loss, proteinuria, and co-localization of F4/80 and MSR1, supporting a pathogenic podocyte–macrophage axis. Conclusion: This study identifies the ANGPTL3-MSR1 axis as a critical pathway linking podocyte injury to macrophage-driven inflammation in LN, highlighting its therapeutic potential. Targeting this axis may disrupt maladaptive immune crosstalk, offering a novel strategy for LN management.
DOI: 10.6084/m9.figshare.31239388
title: Supplementary Material for: Aortic valve Calcification Scores versus CT-FFR: Prediction of MACE after Transcatheter Aortic Valve Replacement

description: Introduction:This study aimed to assess the prognostic value of Aortic valve calcification (AVC) score and CT angiography-derived fractional flow reserve (CT-FFR) for major adverse cardiovascular events (MACE) after transcatheter aortic valve replacement (TAVR). Materials: In this retrospective observational cohort study, we included patients with severe aortic valve diseases undergoing TAVR between February 2016 and April 2022. Patients were followed, and univariable and multivariate Cox regression were applied for outcome analysis using a composite endpoint including all-cause mortality, nonfatal myocardial infarction, unstable angina, heart failure rehospitalization. The incremental prognostic value of CT-FFR was also analyzed. Results: A total of 251 patients were enrolled (mean age, 67 ± 10 years; 176 men). During a mean follow-up period of 36 months, 60 patients (23.9%) experienced MACE. AVC score ≥ 2000 (HR = 1.714, 95%CI: 1.020, 2.882, P = 0.042) and CT-FFR ≤ 0.8 (HR = 3.248, 95% CI: 1.760,5.996, P &lt; 0.001) were independent predictors of MACE. The C statistics revealed that adding CT-FFR to the clinical risk factors alone or combined with AVC score provided incremental prognostic value for MACE after TAVR (C-index: 0.710 vs 0.645 [P = 0.012]; and 0.710 vs 0.672 [P = 0.030]). Conclusion: AVC score and CT-FFR were associated with MACE in patients after TAVR, and CT-FFR presented incremental prognostic value for MACE beyond clinical risk factors alone or combined with AVC score. Therefore, CT-FFR should be incorporated into routine clinical decision-making and risk management for TAVR patients.
DOI: 10.6084/m9.figshare.31239388.v1
title: Supplementary Material for: Aortic valve Calcification Scores versus CT-FFR: Prediction of MACE after Transcatheter Aortic Valve Replacement

description: Introduction:This study aimed to assess the prognostic value of Aortic valve calcification (AVC) score and CT angiography-derived fractional flow reserve (CT-FFR) for major adverse cardiovascular events (MACE) after transcatheter aortic valve replacement (TAVR). Materials: In this retrospective observational cohort study, we included patients with severe aortic valve diseases undergoing TAVR between February 2016 and April 2022. Patients were followed, and univariable and multivariate Cox regression were applied for outcome analysis using a composite endpoint including all-cause mortality, nonfatal myocardial infarction, unstable angina, heart failure rehospitalization. The incremental prognostic value of CT-FFR was also analyzed. Results: A total of 251 patients were enrolled (mean age, 67 ± 10 years; 176 men). During a mean follow-up period of 36 months, 60 patients (23.9%) experienced MACE. AVC score ≥ 2000 (HR = 1.714, 95%CI: 1.020, 2.882, P = 0.042) and CT-FFR ≤ 0.8 (HR = 3.248, 95% CI: 1.760,5.996, P &lt; 0.001) were independent predictors of MACE. The C statistics revealed that adding CT-FFR to the clinical risk factors alone or combined with AVC score provided incremental prognostic value for MACE after TAVR (C-index: 0.710 vs 0.645 [P = 0.012]; and 0.710 vs 0.672 [P = 0.030]). Conclusion: AVC score and CT-FFR were associated with MACE in patients after TAVR, and CT-FFR presented incremental prognostic value for MACE beyond clinical risk factors alone or combined with AVC score. Therefore, CT-FFR should be incorporated into routine clinical decision-making and risk management for TAVR patients.
DOI: 10.34810/data154
title: Seabream cages in Greece and Spain

description: A case study was designed to apply the recommendations obtained in the tasks of the WP2 of MedAID H2020 project in two different sites located along the Mediterranean basin.

Two fish farms in different locationswere selected in West Mediterranean-Spain and East Mediterranean-Greece. A comparison between the results of seabream ongrowing in 2 different sea sites in the Mediterranean sea was carried out during a whole production period (from June 2018 to October 2019) in semi-industrial sea cages (16 m diameter) using the best feeding practices selected from the different research tasks of WP2.

In order to produce comparative data between sites the same batch of fish (provided by Galaxidi Marine Farm in June 2018) and feeds (provided by Dibaq Group when the fish reached 100 g) were used. The fish were fed 2 different feeds in the studied period of low (January-June 2019, 45/16 Protein/Lipid ratio and 22/7 FM/FO) and high (July-October 2019, 45/20 P/L, and 16/7 FM/FO) temperatures with diferent DP/DE and FM/FO ratios, using only one dose per day.

The fish were harvested (420-455 g) and the results in production yield, fillet composition and sensory attributes compared
DOI: 10.6084/m9.figshare.31239340
title: 16S rRNA sequencing of toliet bacterial communities

description: 16S rRNA sequencing of the 35 environmental samples collected in the toilets was performed. The resultant raw sequence dataset (fasta format) is provided. The details can be found in the paper.
DOI: 10.6084/m9.figshare.31239340.v1
title: 16S rRNA sequencing of toliet bacterial communities

description: 16S rRNA sequencing of the 35 environmental samples collected in the toilets was performed. The resultant raw sequence dataset (fasta format) is provided. The details can be found in the paper.
DOI: 10.15151/esrf-es-2303733336
title: Elucidating High Voltage Redox Activity in Cu-based Layered Oxide Materials with High Na content for Sodium-Ion Batteries

description: In this proposal we aim to study the oxygen redox activity in high voltage cathode materials for sodium ion batteries. For this, we plan to measure oxygen K-edge and TM L-edge of layered transition metal oxides with Cu substitution at different states of charge via X-ray Raman scattering spectroscopy (XRS).
DOI: 10.21950/p9jj2p
title: Force vs. deflection in the flexural test

description: El objetivo principal de estos datos es comparar el rendimiento mecánico de muestras de mortero producidas mediante moldeo tradicional e impresión 3D, centrándose en el comportamiento a la flexión. 

La investigación completa se puede encontrar aquí: 
Gil-Lopez, Tomas; Amirfiroozkoohi, Alireza; Valiente-Lopez, Mercedes; Verdu-Vazquez, Amparo (2026). The Impact of 3D Printing on Mortar Strength and Flexibility: A Comparative Analysis of Conventional and Additive Manufacturing Techniques. Accesible online en: https://oa.upm.es/93015/
description: Excel
description: (Dataset.xlsx) con los Fuerza-desplazamiento de las probetas de mortero producidas mediante moldeo tradicional y las obtenidas mediante impresión 3D.
DOI: 10.1594/pangaea.990216
title: Master tracks in different resolutions of POLARSTERN cruise PS151, Bremerhaven - Walvis Bay, 2025-11-13 - 2025-12-12

description: Raw data acquired by position sensors on board RV Polarstern during expedition PS151 was processed to receive a validated master track which can be used as reference of further expedition data. During PS151 two Trimble Marine R750 GPS receivers and the iXBlue HYDRINS hydrographic survey inertial navigation system were used as navigation sensors. Data were downloaded from DAVIS SHIP data base (https://dship.awi.de) with a resolution of 1 sec. Processed data are provided as a master track with 1 sec resolution derived from the position sensors' data selected by priority and a generalized track with a reduced set of the most significant positions of the master track.
description: This dataset contains the master track in 10 min resolution, for other resolutions please see "Other version" references.
DOI: 10.34973/ekbh-q516
title: ENIGMA_3013020.01

description: Archived folders from 3013020.01 ENIGMA-ADHD project space - last update: 31/01/2025

Contents:
- ENIGMA3_Lifespan.zip
- ENIGMA3_QC_BIG.zip
- ENIGMA-CNV.zip
- ENIGMA-plasticity_GWAS.zip
- ENIGMA2_QC_BIG.zip
- MAGeTbrain.zip 
- enigma.backup-30-1-2025.sql.gz
DOI: 10.57710/alba-es-20250340336
title: An in-situ SAXS/WAXD study on the effect of molecular weight distribution and entanglement state on structure evolution in extrusion-based additive manufacturing; part II

description: To value the directionality in for example patient-specific braces and exoskeletons, extrusion-based Additive Manufacturing (AM) strategies and molecular materials design demand alignment first. Properties transverse to the weld interfaces are the everlasting Achilles heel due to the lack of molecular mixing and entangling across the weld interfaces. Contrary, shear and elongational flow-induced shish-kebab morphology, provides design opportunities in the spatial deposition of strength. Our last experiment (2021035145) proved that standard molecular weight designs cannot tie in both requirements. Molecular designs that promote shish-kebab morphology have poor interfacial strength, while shish-kebab structures are lost in molecular designs that provide interfacial strength. A new so-called reactor blend did meet both structural requirements but turned out to be difficult to print in reality. Learning from the soon-published data, we have developed two new blends being discriminative by a reactor-induced disentangled state. The disentangled state facilitates high interfacial strength and good printability. To conclude our study, complement our tensile thermal analysis data, and develop the ultimate polymer formulation for extrusion-based AM, we aim to follow in-situ shish-kebab formation and potential melting as a function of time and spatial position as the AM process proceeds by in situ SAXS/WAXD measurements.
DOI: 10.21227/y8ex-0j18
title: "UniHM"

description: "Human motion synthesis in complex scenes requires rich, multimodal data integrating human motion, static environments, movable objects, and natural language descriptions. Existing datasets are often limited in scale, modality diversity, or scene complexity, constraining the development of scene-aware motion models. To address this, we present the UniHM dataset, a large-scale, unified dataset for human motion and human-object interaction (HOI) in 3D scenes. UniHM combines sequences from HumanML3D, OMOMO, and the newly introduced Lingo Human-Scene-Interaction dataset, standardized to a global SMPL representation and enriched with scene voxels, object point clouds, and multi-text annotations. The dataset contains 44,962 sequences of up to 300 frames each, supporting both Text-to-Motion and Text-to-HOI tasks. By providing comprehensive motion, scene, and object modalities with consistent annotations, UniHM enables the development and evaluation of robust, scene-aware motion synthesis models."
DOI: 10.34810/data41
title: Descriptive statistics of plasma AA concentrations (µmol/L) of calves fed a milk replacer supplemented with different AA combinations

description: The effects on growth performance of supplementation of four different AA combinations in a milk replacer (MR, 25.4% CP and 20.3% fat) based on skimmed milk powder and whey protein concentrate were evaluated in 76 Holstein male calves (3 ± 1.7 d old). The 4 MR were: CTRL with no AA supplementation; PG supplying additional 0.3% Pro and 0.1% Gly; FY supplying additional 0.2% Phe and 0.2% Tyr; KMT providing additional 0.62% Lys, 0.22% Met, and 0.61% Thr. All calves were fed the same milk allowance program and were weaned at 56 d of study. Concentrate intake was limited to minimize interference of potential differences in solid feed intake among treatments. Animals were weighed weekly, intakes recorded daily, and blood samples obtained at 2, 5, and 7 wk of study to determine serum urea and plasma AA concentrations. The file presents data of the backwards selection process to assess the model that fitted better ADG with the study variables (performance, intake, plasma AA balances). Data was collected at Torre Marimon IRTA calf facilities (Caldes de Montbui, Spain) during 2017.
description: Agency Name: Spanish Ministry of Economy and Competitivity
ID: AGL2015-68463-C2-1-P and AGL2015-68463-C2-2
DOI: 10.5281/zenodo.18466130
title: Dexamethasone affects circadian clock in the fetal mouse suprachiasmatic nucleus at transcriptional level

description: Raw RNAseq counts, filtered RNAseq data, quality control report and Python script for analysis.

 

Manuscript abstract

Dexamethasone (DEX) is used in clinical practice as a life-saving therapy in threatened preterm birth; however, such treatment also represents a powerful signal that can reprogram fetal physiology, including circadian system. The effect of DEX on the fetal circadian clock in the suprachiasmatic nuclei (SCN) has been demonstrated, but the underlying mechanism has been unaddressed. The aim of this study was to provide insight into the DEX-induced transcriptional effects in the fetal SCN of mPer2Luc mice. We used triple-labeled immunofluorescence to localize glucocorticoid receptors (GR) in the fetal SCN, cultured ex vivo fetal SCN explants to monitor PER2-driven bioluminescence (PER2::LUC) rhythms, and RNA-seq and RT qPCR analyses to identify genes differentially expressed after DEX and vehicle treatments. We demonstrate that GRs are homogenously expressed in all cells (neuronal and glial nuclei and glial processes) of the fetal SCN. Monitoring PER::LUC in fetal SCN explants confirmed that most cells respond to DEX with improved rhythm quality, a shortened period and increased amplitude. The RNA-seq and RT-qPCR data revealed that DEX increases expression of GR-sensitive clock gene Per1 and changes the expression of other genes that may affect the clock (e.g., Hif3a, Klf9, Zbtb16, Mt1-3). The effects were more significant when the treatment timing matched the temporal window of highest sensitivity of the SCN clock to DEX. Our findings advance the largely unexplored field of chrono-ontogenesis and define the effects of DEX on the fetal brain transcriptional landscape, with specific implications for the circadian clock.
DOI: 10.5281/zenodo.18466131
title: Dexamethasone affects circadian clock in the fetal mouse suprachiasmatic nucleus at transcriptional level

description: Raw RNAseq counts, filtered RNAseq data, quality control report and Python script for analysis.

 

Manuscript abstract

Dexamethasone (DEX) is used in clinical practice as a life-saving therapy in threatened preterm birth; however, such treatment also represents a powerful signal that can reprogram fetal physiology, including circadian system. The effect of DEX on the fetal circadian clock in the suprachiasmatic nuclei (SCN) has been demonstrated, but the underlying mechanism has been unaddressed. The aim of this study was to provide insight into the DEX-induced transcriptional effects in the fetal SCN of mPer2Luc mice. We used triple-labeled immunofluorescence to localize glucocorticoid receptors (GR) in the fetal SCN, cultured ex vivo fetal SCN explants to monitor PER2-driven bioluminescence (PER2::LUC) rhythms, and RNA-seq and RT qPCR analyses to identify genes differentially expressed after DEX and vehicle treatments. We demonstrate that GRs are homogenously expressed in all cells (neuronal and glial nuclei and glial processes) of the fetal SCN. Monitoring PER::LUC in fetal SCN explants confirmed that most cells respond to DEX with improved rhythm quality, a shortened period and increased amplitude. The RNA-seq and RT-qPCR data revealed that DEX increases expression of GR-sensitive clock gene Per1 and changes the expression of other genes that may affect the clock (e.g., Hif3a, Klf9, Zbtb16, Mt1-3). The effects were more significant when the treatment timing matched the temporal window of highest sensitivity of the SCN clock to DEX. Our findings advance the largely unexplored field of chrono-ontogenesis and define the effects of DEX on the fetal brain transcriptional landscape, with specific implications for the circadian clock.
DOI: 10.5281/zenodo.17633095
title: Data for "Ultrafast propagation of magnon-polaritons"

description: This repository contains data and code presented in paper titled: Ultrafast propagation of magnon-polaritons

 

The structure of this archive is divided by the usage of the data in individual figures in paper titled "Ultrafast propagation of magnon-polaritons"

All the presented data are in .csv files with axis includedThe .pdf files of resulting figures are includedThe .pdf file of Fig. 1 was prepared in freeware tool Inkscape and thus the .pdf can be edited in it: https://inkscape.org/The .opju is the source file of OriginLab software and can be opened by freely available tools - https://www.originlab.com/viewer/
DOI: 10.5281/zenodo.17633094
title: Data for "Ultrafast propagation of magnon-polaritons"

description: This repository contains data and code presented in paper titled: Ultrafast propagation of magnon-polaritons

 

The structure of this archive is divided by the usage of the data in individual figures in paper titled "Ultrafast propagation of magnon-polaritons"

All the presented data are in .csv files with axis includedThe .pdf files of resulting figures are includedThe .pdf file of Fig. 1 was prepared in freeware tool Inkscape and thus the .pdf can be edited in it: https://inkscape.org/The .opju is the source file of OriginLab software and can be opened by freely available tools - https://www.originlab.com/viewer/
DOI: 10.6084/m9.figshare.31239412
title: Sediment greenhouse gas production potential and environmental parameter data of bare mudflat wetlands and their neighboring aquaculture ponds in the Dagu River estuary

description: Sediment greenhouse gas production potential and environmental parameter data of bare mudflat wetlands and their neighboring aquaculture ponds in the Dagu River estuary
DOI: 10.6084/m9.figshare.31239412.v1
title: Sediment greenhouse gas production potential and environmental parameter data of bare mudflat wetlands and their neighboring aquaculture ponds in the Dagu River estuary

description: Sediment greenhouse gas production potential and environmental parameter data of bare mudflat wetlands and their neighboring aquaculture ponds in the Dagu River estuary
DOI: 10.5281/zenodo.18466233
title: Dataset for "Quality of Norwegian online health information on ADHD treatment for children and adolescents: Cross-sectional study"
DOI: 10.5281/zenodo.18466232
title: Dataset for "Quality of Norwegian online health information on ADHD treatment for children and adolescents: Cross-sectional study"
DOI: 10.5281/zenodo.17570006
title: Hotspots of multidimensional biodiversity are overlooked by protected areas

description: This folder contains data and R code to reproduce the analyses and results presented in the manuscript entitled "Hotspots of multidimensional biodiversity are overlooked by protected areas". It also contains SI Appendix Dataset S1 [specieslist.csv]