cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.4249922
title: Supplementary Material for: Developmental Characterization of Tail Movements in the Appendicularian Urochordate Oikopleura dioica

description: Using high-speed video cinematography, we characterized kinematically the spontaneous tail movements made by the appendicularian urochordate <i>Oikopleura dioica</i>. Videos of young adult (1-day-old) animals discriminated 4 cardinal movement types: bending, nodding, swimming and filtering, each of which had a characteristic signature including cyclicity, event or cycle duration, cycle frequency, cycle frequency variation, laterality, tail muscle segment coordination and episode duration. Bending exhibited a more common, unilateral form (single bending) and a rarer, bilateral form (alternating bending). Videos of developing animals showed that bending and swimming appeared in rudimentary form starting just after hatching and exhibited developmental changes in movement excursion, duration and frequency, whereas nodding and filtering appeared in the fully mature form in young adults at the time of first house production. More complex behaviors were associated with inflating, entering and exiting the house. We also assessed the influence of descending inputs by separating the tail (which contains all muscles and most likely the neural circuits that generate most motor outputs) from the head. Isolated tails spontaneously generated either bending or swimming movements in abnormally protracted episodes. This together with other observations of interactions between bending and swimming behaviors indicates the presence of several types of descending inputs that regulate the activity of the pattern generating circuitry in the tail nervous system.
DOI: 10.6084/m9.figshare.4249931
title: Supplementary Material for: A Single-Center, Case-Control Study of Low-Dose-Induction Oral Immunotherapy with Cow's Milk

description: <b><i>Background:</i></b> This study aimed to investigate the efficacy and safety of low-dose-induction oral immunotherapy (OIT) with 3 ml of milk, which is a lower target volume than is conventionally used. <b><i>Methods:</i></b> Children aged ≥5 years with milk allergies [confirmed by oral food challenge (OFC) against 3 ml of milk] were enrolled. The OIT group was admitted to the hospital for 5 days for build-up. Subsequently, at home, the volume was gradually increased by up to a maximum of 3 ml every 5 days. While the OIT group ingested a small amount of milk every day, the control group completely eliminated their milk intake. Both groups underwent OFCs approximately 1 year later in order to assess their responsiveness to 3 ml and 25 ml of cow's milk. <b><i>Results:</i></b> The OIT and control groups had no background differences; the proportion of patients unresponsive to 3 ml of milk after 1 year was 58.3% (7/12) and 13.8% (4/25), respectively (p = 0.018), while the proportion unresponsive to 25 ml of milk was 33.3% (4/12) and 0.0% (0/25), respectively (p = 0.007). Furthermore, a significant decrease in the casein-specific immunoglobulin E levels was seen after 12 months when compared to baseline in the OIT group (p = 0.033). Adverse allergic reactions were rare and most symptoms were mild. <b><i>Conclusion:</i></b> This study of a high-risk population reacting to very low amounts of milk showed that low-dose-induction OIT appeared effective for acquiring unresponsiveness to 3 ml and 25 ml of milk, with severe symptoms being rare, indicating that for improvement of food allergies, continuous intake of small amounts may be as effective as intake of larger amounts.
DOI: 10.6084/m9.figshare.4249940.v1
title: Supplementary Material for: Off-Hour Admission and Outcomes in Patients with Acute Intracerebral Hemorrhage in the INTERACT2 Trial

description: <b><i>Background:</i></b> Conflicting data exist of an association between off-hour (weekend, holiday, or night-time) hospital admission and adverse outcome in intracerebral hemorrhage (ICH). We determined the association between off-hour admissions and poor clinical outcome, and of any differential effect of early intensive blood pressure (BP) lowering treatment between off- and on-hour admissions, among participants of the Intensive BP Reduction in Acute Cerebral Hemorrhage Trial (INTERACT2). <b><i>Methods:</i></b> Subsidiary analysis of INTERACT2, a multinational, multicenter, clinical trial of patients with spontaneous ICH with elevated systolic BP, randomly assigned to intensive (target systolic BP &lt;140 mm Hg) or guideline-based (&lt;180 mm Hg) BP management. Primary outcome was death or major disability (modified Rankin scale of 3-6) at 90 days. Off-hour admission was defined as night-time (4:30 p.m. to 8:30 a.m.) on weekdays, weekends (Saturday and Sunday), and public holidays in each participating country. <b><i>Results:</i></b> Of 2,794 patients with information on the primary outcome, 1,770 (63%) were admitted to study centers during off-hours. Off-hour admission was not associated with risk of poor outcome at 90 days (53% off-hour vs. 55% on-hour; p = 0.49), even after adjustment for comorbid risk factors (odds ratio 0.92; 95% CI 0.76-1.12). Consistency exists in the effects of intensive BP lowering between off- and on-hour admission (p = 0.85 for homogeneity). <b><i>Conclusions:</i></b> Off-hour admission was not associated with increased risks of death or major disability among trial protocol participants with acute ICH. Intensive BP lowering can provide similar treatment effect irrespective of admission hours.
DOI: 10.6084/m9.figshare.4249964.v1
title: Supplementary Material for: Epigenetic Dysregulation in the Prefrontal Cortex of Suicide Completers

description: The epigenome is thought to mediate between genes and the environment, particularly in response to adverse life experiences. Similar to other psychiatric diseases, the suicide liability of an individual appears to be influenced by many genetic factors of small effect size as well as by environmental stressors. To identify epigenetic marks associated with suicide, which is considered the endpoint of complex gene-environment interactions, we compared the cortex DNA methylation patterns of 6 suicide completers versus 6 non-psychiatric sudden-death controls, using Illumina 450K methylation arrays. Consistent with a multifactorial disease model, we found DNA methylation changes in a large number of genes, but no changes with large effects reaching genome-wide significance. Global methylation of all analyzed CpG sites was significantly (0.25 percentage point) lower in suicide than in control brains, whereas the vast majority (97%) of the top 1,000 differentially methylated regions (DMRs) were higher methylated (0.6 percentage point) in suicide brains. Annotation analysis of the top 1,000 DMRs revealed an enrichment of differentially methylated promoters in functional categories associated with transcription and expression in the brain. In addition, we performed a comprehensive literature research to identify suicide genes that have been replicated in independent genetic association, brain methylation and/or expression studies. Although, in general, there was no significant overlap between different published data sets or between our top 1,000 DMRs and published data sets, our methylation screen strengthens a number of candidate genes <i>(APLP2</i>, <i>BDNF</i>, <i>HTR1A</i>, <i>NUAK1</i>, <i>PHACTR3</i>, <i>MSMP</i>, <i>SLC6A4</i>, <i>SYN2</i>, and <i>SYNE2)</i> and supports a role for epigenetics in the pathophysiology of suicide.
DOI: 10.6084/m9.figshare.4249922.v1
title: Supplementary Material for: Developmental Characterization of Tail Movements in the Appendicularian Urochordate Oikopleura dioica

description: Using high-speed video cinematography, we characterized kinematically the spontaneous tail movements made by the appendicularian urochordate <i>Oikopleura dioica</i>. Videos of young adult (1-day-old) animals discriminated 4 cardinal movement types: bending, nodding, swimming and filtering, each of which had a characteristic signature including cyclicity, event or cycle duration, cycle frequency, cycle frequency variation, laterality, tail muscle segment coordination and episode duration. Bending exhibited a more common, unilateral form (single bending) and a rarer, bilateral form (alternating bending). Videos of developing animals showed that bending and swimming appeared in rudimentary form starting just after hatching and exhibited developmental changes in movement excursion, duration and frequency, whereas nodding and filtering appeared in the fully mature form in young adults at the time of first house production. More complex behaviors were associated with inflating, entering and exiting the house. We also assessed the influence of descending inputs by separating the tail (which contains all muscles and most likely the neural circuits that generate most motor outputs) from the head. Isolated tails spontaneously generated either bending or swimming movements in abnormally protracted episodes. This together with other observations of interactions between bending and swimming behaviors indicates the presence of several types of descending inputs that regulate the activity of the pattern generating circuitry in the tail nervous system.
DOI: 10.6084/m9.figshare.4249931.v1
title: Supplementary Material for: A Single-Center, Case-Control Study of Low-Dose-Induction Oral Immunotherapy with Cow's Milk

description: <b><i>Background:</i></b> This study aimed to investigate the efficacy and safety of low-dose-induction oral immunotherapy (OIT) with 3 ml of milk, which is a lower target volume than is conventionally used. <b><i>Methods:</i></b> Children aged ≥5 years with milk allergies [confirmed by oral food challenge (OFC) against 3 ml of milk] were enrolled. The OIT group was admitted to the hospital for 5 days for build-up. Subsequently, at home, the volume was gradually increased by up to a maximum of 3 ml every 5 days. While the OIT group ingested a small amount of milk every day, the control group completely eliminated their milk intake. Both groups underwent OFCs approximately 1 year later in order to assess their responsiveness to 3 ml and 25 ml of cow's milk. <b><i>Results:</i></b> The OIT and control groups had no background differences; the proportion of patients unresponsive to 3 ml of milk after 1 year was 58.3% (7/12) and 13.8% (4/25), respectively (p = 0.018), while the proportion unresponsive to 25 ml of milk was 33.3% (4/12) and 0.0% (0/25), respectively (p = 0.007). Furthermore, a significant decrease in the casein-specific immunoglobulin E levels was seen after 12 months when compared to baseline in the OIT group (p = 0.033). Adverse allergic reactions were rare and most symptoms were mild. <b><i>Conclusion:</i></b> This study of a high-risk population reacting to very low amounts of milk showed that low-dose-induction OIT appeared effective for acquiring unresponsiveness to 3 ml and 25 ml of milk, with severe symptoms being rare, indicating that for improvement of food allergies, continuous intake of small amounts may be as effective as intake of larger amounts.
DOI: 10.6084/m9.figshare.4249907
title: Supplementary Material for: Long-Term Angiotensin II Receptor Blockade Limits Hypertension, Aortic Dysfunction, and Structural Remodeling in a Rat Model of Chronic Kidney Disease

description: <b><i>Background/Aims:</i></b> Chronic kidney disease (CKD) is associated with large artery remodeling, endothelial dysfunction and calcification, with angiotensin II (Ang II) a known driver of these pathologies. We investigated long-term Ang II type 1 receptor inhibition with valsartan on aortic function and structure in the Lewis polycystic kidney (LPK) rat model of CKD. <b><i>Methods:</i></b> Mixed sex LPK and Lewis control (total <i>n</i> = 28) treated (valsartan 60 mg/kg/day p.o. from 4 to 18 weeks) and vehicle groups were studied. Functional responses to noradrenaline (NA), potassium chloride and endothelium-dependent and independent relaxations were investigated in vitro using acetylcholine hydrochloride (ACh) and sodium nitroprusside (SNP), respectively. Effects of the nitric oxide synthase (NOS) substrate L-arginine, NOS inhibitor L-NAME and cyclooxygenase inhibitor indomethacin on ACh responses were examined. <b><i>Results:</i></b> In the LPK, valsartan reduced systolic blood pressure and urinary protein, ameliorated exaggerated sensitivity to NA, and normalized endothelium-dependent (ACh-R<sub>max</sub>; 91 ± 7 vs. 59 ± 6%, <i>p</i> = 0.0001) and independent dysfunction (SNP-R<sub>max</sub>; 99 ± 1 vs. 82 ± 7%, <i>p</i> = 0.040), as well as improving NO-dependent relaxation (R<sub>max</sub>; -51 ± 6 vs. -26 ± 9%, <i>p</i> = 0.008). Valsartan also reduced aortic wall hypertrophy, elastin disruption/fragmentation, calcification, media cystic degeneration, and levels of matrix metalloproteinase 9. <b><i>Conclusions:</i></b> This study highlights the role of Ang II in driving vascular manifestations of CKD and indicates that early treatment can significantly limit pathological changes.
DOI: 10.6084/m9.figshare.4249907.v1
title: Supplementary Material for: Long-Term Angiotensin II Receptor Blockade Limits Hypertension, Aortic Dysfunction, and Structural Remodeling in a Rat Model of Chronic Kidney Disease

description: <b><i>Background/Aims:</i></b> Chronic kidney disease (CKD) is associated with large artery remodeling, endothelial dysfunction and calcification, with angiotensin II (Ang II) a known driver of these pathologies. We investigated long-term Ang II type 1 receptor inhibition with valsartan on aortic function and structure in the Lewis polycystic kidney (LPK) rat model of CKD. <b><i>Methods:</i></b> Mixed sex LPK and Lewis control (total <i>n</i> = 28) treated (valsartan 60 mg/kg/day p.o. from 4 to 18 weeks) and vehicle groups were studied. Functional responses to noradrenaline (NA), potassium chloride and endothelium-dependent and independent relaxations were investigated in vitro using acetylcholine hydrochloride (ACh) and sodium nitroprusside (SNP), respectively. Effects of the nitric oxide synthase (NOS) substrate L-arginine, NOS inhibitor L-NAME and cyclooxygenase inhibitor indomethacin on ACh responses were examined. <b><i>Results:</i></b> In the LPK, valsartan reduced systolic blood pressure and urinary protein, ameliorated exaggerated sensitivity to NA, and normalized endothelium-dependent (ACh-R<sub>max</sub>; 91 ± 7 vs. 59 ± 6%, <i>p</i> = 0.0001) and independent dysfunction (SNP-R<sub>max</sub>; 99 ± 1 vs. 82 ± 7%, <i>p</i> = 0.040), as well as improving NO-dependent relaxation (R<sub>max</sub>; -51 ± 6 vs. -26 ± 9%, <i>p</i> = 0.008). Valsartan also reduced aortic wall hypertrophy, elastin disruption/fragmentation, calcification, media cystic degeneration, and levels of matrix metalloproteinase 9. <b><i>Conclusions:</i></b> This study highlights the role of Ang II in driving vascular manifestations of CKD and indicates that early treatment can significantly limit pathological changes.
DOI: 10.6084/m9.figshare.4249883
title: Rugby Scrum - Machine Scrummaging Data

description: Experimental data and simulation output of a 120 kg rugby forward players scrummaging against an instrumented scrum machine.<br>DATA include:-) Scaled and adjusted model-) External loads-) Joint angles from Inverse Kinematics (IK) performed in OpenSim 3.2-) Joint kinetics from Inverse Dynamics (ID) performed in OpenSim 3.2-) Residual Reduction Analysis (RRA) output performed in OpenSim 3.2<br>
DOI: 10.6084/m9.figshare.4249883.v1
title: Rugby Scrum - Machine Scrummaging Data

description: Experimental data of a 120 kg rugby forward players scrummaging against an instrumented scrum machine.<br>DATA include:-) Scaled and adjusted model-) External loads-) Joint angles from Inverse Kinematics-) Joint kinetics from Inverse Dynamics-) Residual Reduction Analysis output-) Joint Reaction Forces calculated by using a modified version of the scaled model (no muscles).<br>
DOI: 10.6084/m9.figshare.4249814
title: Increasing amount of amyloid are associated with the severity of clinical features in hereditary gelsolin (AGel) amyloidosis

description: <i>Background</i>: Patients with hereditary gelsolin (AGel) amyloidosis (HGA) present with hanging skin (cutis laxa) and bilateral cranial neuropathy, and require symptomatic plastic surgery. Our clinical observation of tissue fragility prompted us to design a prospective study. <i>Methods</i>: Twenty-nine patients with HGA undergoing surgery were interviewed and clinically examined. The height and thickness of skin folds in standard anatomical localizations were measured. The presence and distribution of amyloid in skin samples were analyzed using Congo red staining and immunohistochemistry using antibodies against gelsolin amyloid (AGel) subunit. <i>Results</i>: The measured skin folds stretched more in patients with HGA (e.g. skin over olecranon, <i>p</i> p <i>Conclusions</i>: The AGel amyloid in the skin and subcutis, together with morphologic changes in the dermal stroma and skin adnexa contribute to the atrophied and fragile structure of HGA skin. This is the first study to demonstrate the correlation between AGel amyloid accumulation and clinical disease severity.
DOI: 10.6084/m9.figshare.4249814.v1
title: Increasing amount of amyloid are associated with the severity of clinical features in hereditary gelsolin (AGel) amyloidosis

description: <i>Background</i>: Patients with hereditary gelsolin (AGel) amyloidosis (HGA) present with hanging skin (cutis laxa) and bilateral cranial neuropathy, and require symptomatic plastic surgery. Our clinical observation of tissue fragility prompted us to design a prospective study. <i>Methods</i>: Twenty-nine patients with HGA undergoing surgery were interviewed and clinically examined. The height and thickness of skin folds in standard anatomical localizations were measured. The presence and distribution of amyloid in skin samples were analyzed using Congo red staining and immunohistochemistry using antibodies against gelsolin amyloid (AGel) subunit. <i>Results</i>: The measured skin folds stretched more in patients with HGA (e.g. skin over olecranon, <i>p</i> p <i>Conclusions</i>: The AGel amyloid in the skin and subcutis, together with morphologic changes in the dermal stroma and skin adnexa contribute to the atrophied and fragile structure of HGA skin. This is the first study to demonstrate the correlation between AGel amyloid accumulation and clinical disease severity.
DOI: 10.6084/m9.figshare.4249808.v1
title: MASI

description: Provides the MASI (.osim) file that can be used in OpenSim.<br> The ‘Musculoskeletal model for the Analysis of Spinal Injury’ (MASI) wascreated in OpenSim (OpenSim 3.2, Simbios, Stanford, CA, USA) and Matlab software (Matlab 2013b, MathWorks, Natick, MA, USA).MASI inherited the structure of the OpenSim head and neck model (Vasavada Model) which we embedded into a full body model (‘2354’), and was implemented to provide, for the first time, the linkage between cervical spine, upper limb, torso and lower limbs. MASI comprises 35 rigid anatomical segments, 78 upper and lower cervical muscles divided into 19 muscle groups, along with 23 torque actuators representing lower and upper limb muscles’ actions. Motion between body segments was permitted via 34 joints and 30 kinematic constraints. To incorporate the effect of upper limb position, a new scapula-clavicular joint (SCJ) (combining the joint motions of the acromioclavicular and sternoclavicular joints) was developed and included in the MASI, replacing the welded scapula-clavicular joint of the original head and neck model. The model had 43 degrees of freedom, though these were reduced to 37 by locking the metatarsophalangeal and wrist joints into the neutral position.
DOI: 10.6084/m9.figshare.4249778
title: Supplementary Dataset 2 from <i>In situ</i> developmental responses of tropical sea urchin embryos to ocean acidification conditions at naturally elevated <i>p</i>CO<sub>2</sub> vent sites

description: Experiment 2 Larval Measurements
DOI: 10.6084/m9.figshare.4249781
title: Supplementary Dataset 2 from <i>In situ</i> developmental responses of tropical sea urchin embryos to ocean acidification conditions at naturally elevated <i>p</i>CO<sub>2</sub> vent sites

description: Experiment 2 Larval Measurements
DOI: 10.6084/m9.figshare.4249778.v1
title: Supplementary Dataset 2 from <i>In situ</i> developmental responses of tropical sea urchin embryos to ocean acidification conditions at naturally elevated <i>p</i>CO<sub>2</sub> vent sites

description: Experiment 2 Larval Measurements
DOI: 10.6084/m9.figshare.4249781.v2
title: Supplementary Dataset 2 from <i>In situ</i> developmental responses of tropical sea urchin embryos to ocean acidification conditions at naturally elevated <i>p</i>CO<sub>2</sub> vent sites

description: Experiment 2 Larval Measurements
DOI: 10.6084/m9.figshare.4249781.v1
title: Supplementary Dataset 1 from <i>In situ</i> developmental responses of tropical sea urchin embryos to ocean acidification conditions at naturally elevated <i>p</i>CO<sub>2</sub> vent sites

description: Experiment 1 Larval Measurements
DOI: 10.6084/m9.figshare.4249691
title: Model code 2:ESM Pavlova etal CODE Allee WC from Allee effect in polar bears: a potential consequence of polychlorinated biphenyls contamination

description: Model code: weight-rule competition
DOI: 10.6084/m9.figshare.4249688
title: Model code 3:ESM Pavlova etal CODE Allee RC from Allee effect in polar bears: a potential consequence of polychlorinated biphenyls contamination

description: Model code: no competition
DOI: 10.6084/m9.figshare.4249691.v1
title: Model code 2:ESM Pavlova etal CODE Allee WC from Allee effect in polar bears: a potential consequence of polychlorinated biphenyls contamination

description: Model code: weight-rule competition
DOI: 10.6084/m9.figshare.4249685
title: Model code 1:ESM Pavlova etal CODE Allee RC from Allee effect in polar bears: a potential consequence of polychlorinated biphenyls contamination

description: Model code: random-rule competition
DOI: 10.6084/m9.figshare.4249688.v1
title: Model code 3:ESM Pavlova etal CODE Allee RC from Allee effect in polar bears: a potential consequence of polychlorinated biphenyls contamination

description: Model code: no competition
DOI: 10.6084/m9.figshare.4249676
title: Reactivation of Mandarin unaccusative and unergative verbs

description: Reactivation of Mandarin unaccusative and unergative verbs<br>
DOI: 10.6084/m9.figshare.4249646
title: Single dose caffeine protects the neonatal mouse brain against hypoxia ischemia - Flow cytometric data

description: Caffeine 5mg/kg or phosphate buffered saline given directly after sham operation or brain hypoxia ischemia. Flow cytometric evaluation of brain immune cell content 24h, 72h and 2 weeks after brain injury. <br>
DOI: 10.6084/m9.figshare.4249676.v1
title: Reactivation of Mandarin unaccusative and unergative verbs

description: Reactivation of Mandarin unaccusative and unergative verbs<br>
DOI: 10.6084/m9.figshare.4249676.v2
title: Reactivation of Mandarin unaccusative and unergative verbs

description: Reactivation of Mandarin unaccusative and unergative verbs<br>
DOI: 10.6084/m9.figshare.4249676.v4
title: Reactivation of Mandarin unaccusative and unergative verbs

description: Reactivation of Mandarin unaccusative and unergative verbs<br>
DOI: 10.6084/m9.figshare.4249676.v3
title: Reactivation of Mandarin unaccusative and unergative verbs

description: Reactivation of Mandarin unaccusative and unergative verbs<br>
DOI: 10.6084/m9.figshare.4249613
title: SI to "Radical Reaction Control in the AdoMet Radical Enzyme CDG Synthase (QueE): Consolidate, Destabilize, Accelerate"

description: Supporting Information for "Radical Reaction Control in the AdoMet Radical Enzyme CDG Synthase (QueE): Consolidate, Destabilize, Accelerate"
DOI: 10.6084/m9.figshare.4249613.v1
title: SI to "Radical Reaction Control in the AdoMet Radical Enzyme CDG Synthase (QueE): Consolidate, Destabilize, Accelerate"

description: Supporting Information for "Radical Reaction Control in the AdoMet Radical Enzyme CDG Synthase (QueE): Consolidate, Destabilize, Accelerate"