cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.24721710
title: Supplementary Material for: Gastric polyps in Familial Adenomatous Polyposis Portuguese patients: the first Western cohort with Asian features

description: Introduction: Chronic atrophic gastritis may contribute to gastric polyps (GP) phenotype in familial adenomatous polyposis (FAP). Considering the high prevalence of Helicobacter-pylori (HP) infection in Portugal, we aim to characterise GP in a series of Portuguese patients.
Methods: In a retrospectively-selected series of 53 FAP patients, clinical data and histopathological features of GP and background gastric mucosa were studied. SPSS (27.0) was used for statistical analysis.
Results: Thirteen patients (24.5%) developed fundic gland polyps (FGP), seven (13.2%) gastric adenomas (GA) and ten (18.9%) both FGP and GA. Out of 100 GP, four were hyperplastic polyps, 58 FGP (24 with dysplasia), 35 intestinal-type GA (intGA) and three foveolar-type GA (fovGA). IntGA were larger (60% &gt;7mm, p=0.03), occurred predominantly in the distal stomach (66.7%, p=0.024), in patients harbouring gastric intestinal metaplasia (IM) (86.7%, p&lt;0.001) and duodenal adenomas (86.7%, p&lt;0.001)
Conclusion: This is the first Western series showing high prevalence of intGA in FAP patients, comparable to Asian cohorts. HP infection and chronic atrophic gastritis/intestinal metaplasia are likely responsible for this difference, with risk of neoplastic transformation and management implications. Biopsy/excision of GP &gt;7mm, in the distal stomach, and in patients harbouring gastric intestinal metaplasia/duodenal adenomas should be considered.
DOI: 10.6084/m9.figshare.24588762.v1
title: Supplementary Material for: Prevalence and Prognostic Value of Atrial Cardiopathy in Embolic Stroke of Undetermined Source

description: Introduction: We utilized data from the Third China National Stroke Registry to investigate the prevalence of atrial cardiopathy markers in patients with embolic stroke of undetermined source (ESUS) and to assess their association with death and stroke recurrence. Methods: In China, patients experiencing transient ischemic attack or ischemic stroke were recruited consecutively by the Third China National Stroke Registry. We compared atrial cardiopathy markers, such as left atrial (LA) enlargement, increased P-wave terminal force in lead V1 (PTFV1), premature atrial contractions, paroxysmal supraventricular tachycardia, advanced interatrial block, prolonged PR interval, prolonged P-wave dispersion, and prolonged P-wave duration between ESUS patients and those with small vessel disease and large artery atherosclerosis strokes. The association between these markers and the recurrence of stroke as well as mortality risk in ESUS patients was evaluated using Cox regression analysis. Results: Of 8528 ischemic stroke patients who underwent a standard diagnostic work-up, 2415 were identified as having ESUS. Multivariable analysis revealed a significant association between elevated PTFV1 and an increased risk of stroke recurrence (HR: 2.50; 95% CI: 1.53-4.09; p &lt; 0.01) as well as mortality (HR: 3.76; 95% CI: 1.58-8.91; p &lt; 0.01) at 1 year in patients with ESUS. Furthermore, we observed that moderate-severe LA enlargement slightly increased the risk of stroke recurrence in patients with ESUS (HR: 1.95; 95% CI: 0.90-4.26; p = 0.09). Both LA diameter (HR: 1.03; 95% CI: 1.00-1.06; p = 0.03) and the top quartile of the LA diameter index (HR: 1.56; 95% CI: 1.03-2.40; p = 0.04) were associated with stroke recurrence in patients with ESUS. Conclusions: PTFV1 was independently associated with an elevated risk of stroke recurrence and mortality in ESUS patients. Additionally, a trend toward a correlation between LA enlargement and high stroke recurrence risk after ESUS was observed.
DOI: 10.6084/m9.figshare.24542056
title: Supplementary Material for: Prevalence and impact of frailty in patients ≥70 years old with acute coronary syndrome referred for coronary angiography

description: Introduction 
Elderly patients with acute coronary syndrome (ACS) have a higher risk of adverse cardiovascular events and may be frail but are underrepresented in clinical trials. Previous studies have proposed that frailty assessment is a better tool than chronological age, in assessing older patients’ biological age, and may exceed conventional risk scores in predicting prognosis. Therefore, we wanted to investigate prevalence and impact on 12-month outcomes of frailty in patients ≥70 years with ACS referred for coronary angiography (CAG).

Methods
Patients ≥70 years with ACS referred for CAG underwent frailty scoring with the clinical frailty scale (CFS). Patients were divided into three groups depending on their CFS: Robust (1-3), Vulnerable (4) and Frail (5-9) and followed for 12 months.

Results
Of 455 patients, 69 (15%) patients were frail, 79 (17%) were vulnerable and 307 (68%) were robust. Frail patients were older (frail: 80.9±5.7 years, vulnerable: 78.5±5.5 years and robust 76.6±4.9 years, p&lt;0.001) and less often treated with percutaneous coronary intervention (frail: 56.5%, vulnerable: 53.2% and robust: 68.6%, p=0.014). 12-month mortality was higher among frail patients (frail: 24.6%, vulnerable: 21.8% and robust: 6.2%, p&lt;0.001). Frailty was associated with a higher mortality after adjustment for age, sex, comorbidities, GRACE score and revascularisation (HR 2.67, 95%CI 1.30-5.50, p=0.008). There was no difference between GRACE and CFS in predicting 12-month mortality (p=0.893).

Conclusions 
15% of patients ≥70 years with ACS referred for CAG are frail. Frail patients have significantly higher 12-month mortality. GRACE and CFS are similar in predicting 12-month mortality.
DOI: 10.6084/m9.figshare.24542056.v1
title: Supplementary Material for: Prevalence and impact of frailty in patients ≥70 years old with acute coronary syndrome referred for coronary angiography

description: Introduction 
Elderly patients with acute coronary syndrome (ACS) have a higher risk of adverse cardiovascular events and may be frail but are underrepresented in clinical trials. Previous studies have proposed that frailty assessment is a better tool than chronological age, in assessing older patients’ biological age, and may exceed conventional risk scores in predicting prognosis. Therefore, we wanted to investigate prevalence and impact on 12-month outcomes of frailty in patients ≥70 years with ACS referred for coronary angiography (CAG).

Methods
Patients ≥70 years with ACS referred for CAG underwent frailty scoring with the clinical frailty scale (CFS). Patients were divided into three groups depending on their CFS: Robust (1-3), Vulnerable (4) and Frail (5-9) and followed for 12 months.

Results
Of 455 patients, 69 (15%) patients were frail, 79 (17%) were vulnerable and 307 (68%) were robust. Frail patients were older (frail: 80.9±5.7 years, vulnerable: 78.5±5.5 years and robust 76.6±4.9 years, p&lt;0.001) and less often treated with percutaneous coronary intervention (frail: 56.5%, vulnerable: 53.2% and robust: 68.6%, p=0.014). 12-month mortality was higher among frail patients (frail: 24.6%, vulnerable: 21.8% and robust: 6.2%, p&lt;0.001). Frailty was associated with a higher mortality after adjustment for age, sex, comorbidities, GRACE score and revascularisation (HR 2.67, 95%CI 1.30-5.50, p=0.008). There was no difference between GRACE and CFS in predicting 12-month mortality (p=0.893).

Conclusions 
15% of patients ≥70 years with ACS referred for CAG are frail. Frail patients have significantly higher 12-month mortality. GRACE and CFS are similar in predicting 12-month mortality.
DOI: 10.6073/pasta/a3c42bfbe3a2835fd33c98f8ea1e9565
title: Lake Sediment Pollen from Benson Pond in Washington MA from 13834 BP to Present

description: Aim
 We analyzed a dataset composed of multiple palaeoclimate and lake-sediment pollen records from New England to explore how postglacial changes in the composition and spatial patterns of vegetation were controlled by regional-scale climate change, a subregional environmental gradient, and landscape-scale variations in soil characteristics.
 
 
 Location
 The 120,000-km2 study area includes parts of Vermont and New Hampshire in the north, where sites are 150-200 km from the Atlantic Ocean, and spans the coastline from southeastern New York to Cape Cod and the adjacent islands, including Block Island, the Elizabeth Islands, Nantucket, and Martha’s Vineyard.
 
 
 Results
 Boreal forest featuring Picea and Pinus banksiana was present across the region when conditions were cool and dry 14,000-12,000 calibrated 14C years before present (ybp). Pinus strobus became regionally dominant as temperatures increased between 12,000 and 10,000 ybp. The composition of forests in inland and coastal areas diverged in response to further warming after 10,000 ybp, when Quercus and Pinus rigida expanded across southern New England, while conditions remained cool enough in inland areas to maintain Pinus strobus. Increasing precipitation allowed Tsuga canadensis, Fagus grandifolia, and Betula to replace Pinus strobus in inland areas during 9000-8000 ybp, and also led to the expansion of Carya across the coastal part of the region beginning at 7000-6000 ybp. Abrupt cooling at 5500-5000 ybp caused sharp declines in Tsuga in inland areas and Quercus at some coastal sites, and the populations of those taxa remained low until they recovered around 3000 ybp in response to rising precipitation. Throughout most of the Holocene, sites underlain by sandy glacial deposits were occupied by Pinus rigida and Quercus.
 
 
 Main conclusions
 Postglacial changes in the composition and spatial pattern of New England forests were controlled by long-term trends and abrupt shifts in temperature and precipitation, as well as by the environmental gradient between coastal and inland parts of the region. Substrate and soil moisture shaped landscape-scale variations in forest composition.
DOI: 10.6084/m9.figshare.24559177
title: Supplementary Material for: Infectious Disease Screening Prior to Systemic Immunomodulatory Therapy in Hidradenitis Suppurativa: Consensus Guidelines from the Asia-Pacific Hidradenitis Suppurativa Foundation

description: Background: Current infectious disease screening recommendations for hidradenitis suppurativa (HS) are adopted from recommendations in chronic plaque psoriasis. No HS-specific guidelines for infectious disease screening prior to immunomodulatory therapy have been developed.
Objectives: To establish an expert Delphi consensus of recommendations regarding infectious disease screening prior to systemic immunomodulatory therapy in HS.
Methods: Participants were identified via recent publications in the field and were sent a questionnaire regarding infectious diseases encountered in the setting of HS, and opinions regarding infectious disease screening prior to various systemic immunomodulatory therapies. All questions were informed by a systematic literature review regarding infections exacerbated or precipitated by immunomodulatory therapy. Questionnaire responses were followed by round-table discussion with a core group of 8 experts followed by a final round of questionnaires resulting in achievement of consensus.
Results: 44 expert HS physicians from 12 countries on 5 continents participated in the development of the expert consensus recommendations. Consensus recommendations include screening for hepatitis B, hepatitis C and tuberculosis in all individuals with HS prior to therapy. All immunomodulatory therapies (biologic and systemic immunosuppressant therapy) should be preceded by infectious disease screening including patient and location specific considerations for endemic local diseases and high-risk activities and occupations. Clinical assessment has a significant role in determining the need for laboratory screening in the setting of many uncommon or tropical diseases such as leprosy, leishmaniasis and strongyloidiasis. 
Conclusions: The presented consensus recommendations are the first specifically developed for pre-treatment infectious disease screening in Hidradenitis Suppurativa.
DOI: 10.6084/m9.figshare.24559177.v1
title: Supplementary Material for: Infectious Disease Screening Prior to Systemic Immunomodulatory Therapy in Hidradenitis Suppurativa: Consensus Guidelines from the Asia-Pacific Hidradenitis Suppurativa Foundation

description: Background: Current infectious disease screening recommendations for hidradenitis suppurativa (HS) are adopted from recommendations in chronic plaque psoriasis. No HS-specific guidelines for infectious disease screening prior to immunomodulatory therapy have been developed.
Objectives: To establish an expert Delphi consensus of recommendations regarding infectious disease screening prior to systemic immunomodulatory therapy in HS.
Methods: Participants were identified via recent publications in the field and were sent a questionnaire regarding infectious diseases encountered in the setting of HS, and opinions regarding infectious disease screening prior to various systemic immunomodulatory therapies. All questions were informed by a systematic literature review regarding infections exacerbated or precipitated by immunomodulatory therapy. Questionnaire responses were followed by round-table discussion with a core group of 8 experts followed by a final round of questionnaires resulting in achievement of consensus.
Results: 44 expert HS physicians from 12 countries on 5 continents participated in the development of the expert consensus recommendations. Consensus recommendations include screening for hepatitis B, hepatitis C and tuberculosis in all individuals with HS prior to therapy. All immunomodulatory therapies (biologic and systemic immunosuppressant therapy) should be preceded by infectious disease screening including patient and location specific considerations for endemic local diseases and high-risk activities and occupations. Clinical assessment has a significant role in determining the need for laboratory screening in the setting of many uncommon or tropical diseases such as leprosy, leishmaniasis and strongyloidiasis. 
Conclusions: The presented consensus recommendations are the first specifically developed for pre-treatment infectious disease screening in Hidradenitis Suppurativa.
DOI: 10.6073/pasta/2f65a58c1c45bfc6fcbf70d1490e3382
title: Lake Sediment Pollen from Berry Pond in North Andover MA from 13676 BP to Present

description: Aim
 We analyzed a dataset composed of multiple palaeoclimate and lake-sediment pollen records from New England to explore how postglacial changes in the composition and spatial patterns of vegetation were controlled by regional-scale climate change, a subregional environmental gradient, and landscape-scale variations in soil characteristics.
 
 
 Location
 The 120,000-km2 study area includes parts of Vermont and New Hampshire in the north, where sites are 150-200 km from the Atlantic Ocean, and spans the coastline from southeastern New York to Cape Cod and the adjacent islands, including Block Island, the Elizabeth Islands, Nantucket, and Martha’s Vineyard.
 
 
 Results
 Boreal forest featuring Picea and Pinus banksiana was present across the region when conditions were cool and dry 14,000-12,000 calibrated 14C yrs before present (ybp). Pinus strobus became regionally dominant as temperatures increased between 12,000 and 10,000 ybp. The composition of forests in inland and coastal areas diverged in response to further warming after 10,000 ybp, when Quercus and Pinus rigida expanded across southern New England, while conditions remained cool enough in inland areas to maintain Pinus strobus. Increasing precipitation allowed Tsuga canadensis, Fagus grandifolia, and Betula to replace Pinus strobus in inland areas during 9000-8000 ybp, and also led to the expansion of Carya across the coastal part of the region beginning at 7000-6000 ybp. Abrupt cooling at 5500-5000 ybp caused sharp declines in Tsuga in inland areas and Quercus at some coastal sites, and the populations of those taxa remained low until they recovered around 3000 ybp in response to rising precipitation. Throughout most of the Holocene, sites underlain by sandy glacial deposits were occupied by Pinus rigida and Quercus.
 
 
 Main conclusions
 Postglacial changes in the composition and spatial pattern of New England forests were controlled by long-term trends and abrupt shifts in temperature and precipitation, as well as by the environmental gradient between coastal and inland parts of the region. Substrate and soil moisture shaped landscape-scale variations in forest composition.
DOI: 10.6084/m9.figshare.24589614.v1
title: Supplementary Material for: Association between Fibrinogen-to-Albumin Ratio and Adverse Stroke Outcomes among Patients with Acute Ischemic Stroke

description: Introduction: Fibrinogen-to-albumin ratio (FAR) is implicated in prothrombotic states and is associated with an increased risk of acute ischemic stroke (AIS). However, studies investigating whether the prothrombotic effect of FAR is associated with long-term adverse outcomes in patients with AIS are lacking. Therefore, we aimed to investigate the association based on The Third China National Stroke Registry (CNSR-III). 
Methods: Patients with AIS with complete laboratory data for fibrinogen and albumin in the CNRS-III were included in this study. The primary outcomes were poor functional outcomes (modified Rankin scale score 3–6) at 12 months, including disability (modified Rankin scale score 3–5), all-cause death, recurrent stroke, and combined vascular events within 1 year. Univariate and multivariate logistic or Cox regression analyses were used to investigate the association between FAR quartiles and adverse outcomes. 
Results: A total of 8984 patients with AIS were enrolled in this study. After one-year follow-up, 238 patients were lost to follow-up. A total of 1230(14.06%) patients had poor functional outcomes; 932(10.37%) and 981(10.92%) experienced stroke recurrence and combined vascular events, respectively. The adjusted odds ratios/hazard ratios and 95% confidence intervals of the highest quartile of the FAR(&gt;11.44) were 1.64(1.35-2.00) for poor functional outcomes, 1.68(1.34-2.10) for disability, 1.40(1.02-1.94) for all-cause death, 1.11(0.92-1.34) for stroke recurrence, and 1.11(0.92-1.33) for combined vascular event, respectively. 
Conclusion: High FAR(&gt;11.44) increased the risk of short- and long-term poor functional outcomes, including disability and all-cause death among patients with AIS. The FAR may play an important role in the early stratification of patients with AIS.
DOI: 10.6073/pasta/be7e01d7c339220d948aef54e982443f
title: Watershed 18 daily stream discharge, Coweeta Hydrologic Laboratory, Otto, NC, 1936-2018

description: Watershed 18 or Grady Branch is a northwest facing reference catchment encompassing 30.84ac (12.48ha) or .04819 sq. miles. The elevation ranges from 2382ft (726m) at the weir to 3258ft (993m). The average land slope is 52.5%, and the average channel slope is 18.9%. The channel is a total of 924ft (281.6m) long. Additional USDA Forest Service Data can be found at this link: http://www.srs.fs.usda.gov/coweeta/tools-and-data/
DOI: 10.60520/ieda/113073
title: NWERN Dust Microbial Community Results

description: Dust was collected from NWERN sites spanning the western United States. DNA extractions and sequencing were performed on samples. Metadata can be found in the "mapper" file, with community details in the Bacterial Commonality Plot.
DOI: 10.6073/pasta/75fc67212f315c52cfe14b29627315df
title: Watershed 27 daily stream discharge, Coweeta Hydrologic Laboratory, Otto, NC, 1946-2018

description: Watershed 27 or Hard Luck Creek is a north-northeast facing reference catchment encompassing 96.5 acres (39ha) or .15080 sq. miles. The elevation ranges from 3380ft (1061m) at the weir to 4770ft (1454m). The average land slope is 54.7%, and the average channel slope is 33.2%. The channel is a total of 3894ft (1187m) long. Additional USDA Forest Service Data can be found at this link: http://www.srs.fs.usda.gov/coweeta/tools-and-data/
DOI: 10.26093/cds/aladin/17gt-cfe
title: HLA-B : F450W, F439W, F438W, F435W HiPS

description: The HST-HLA Hierarchical Progressive Survey (HiPS) has been built by Daniel Durand from CADC and distributed by CDS. It sets together all HST observations done in F450W, F439W, F438W, F435W filters between the beginning of the mission to the 4th of October 2014.The Hubble Space Telescope (HST) is a cooperative program of the European Space Agency (ESA) and the National Aeronautics and Space Administration (NASA) to operate a space-based observatory for the benefit of the international astronomical community. The Hubble Legacy Archive (HLA) is designed to optimize science from the Hubble Space Telescope by providing online, enhanced Hubble products and advanced browsing capabilities. The HLA is a joint project of the Space Telescope Science Institute (STScI), the Space Telescope European Coordinating Facility (ST-ECF), and the Canadian Astronomy Data Centre (CADC). Currently we have enhanced image products for ACS, WFPC2, WFC3, and NICMOS, extracted spectra from NICMOS and ACS grism observations. The enhanced data products were generated from the standard HST pipeline products. The ACS, WFPC2, and WFC3, and NICMOS images have been combin ed using MultiDrizzle, are aligned north up, and, except for WFC3, have been astrometrically corrected when possible (for approximately 80% of the cases). All HLA-produced images are in units of electrons/second, which for WFPC2 and NICMOS differs from calibration pipeline products; photometric zeropoints must be adjusted to reflect the units used.
DOI: 10.6073/pasta/94e5a3203dc10ce1497813191a3e9f25
title: Microclimate Measurements from the Terrestrial Gradient Plots, Coweeta Hydrologic Laboratory, North Carolina

description: The terrestrial gradient study at Coweeta compares vegetation, soils, and understory microclimate of five sites: 118 low elevation (782 m) pine-oak, 218 low elevation (795 m) cove hardwood, 318 low elevation (865 m) mixed oak, 427 high elevation (1001 m) mixed oak, 527 high elevation (1347 m) northern hardwood. Understory microclimate stations were installed in representative locations at the downslope margin of each 20 x 40 m gradient plot (within the 80 x 80 m plot).