cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.14344922
title: Supplementary Material for: The Two Formyl Peptide Receptors Differently Regulate GPR84-Mediated Neutrophil NADPH Oxidase Activity

description: Neutrophils express the two formyl peptide receptors (FPR1 and FPR2) and the medium-chain fatty acid receptor GPR84. The FPRs are known to define a hierarchy among neutrophil G protein-coupled receptors (GPCRs), that is, the activated FPRs can either suppress or amplify GPCR responses. In this study, we investigated the position of GPR84 in the FPR-defined hierarchy regarding the activation of neutrophil nicotine adenine dinucleotide phosphate (NADPH) oxidase, an enzyme system designed to generate reactive oxygen species (ROS), which are important regulators in cell signaling and immune regulation. When resting neutrophils were activated by GPR84 agonists, a modest ROS release was induced. However, vast amounts of ROS were induced by these GPR84 agonists in FPR2-desensitized neutrophils, and the response was inhibited not only by a GPR84-specific antagonist but also by an FPR2-specific antagonist. This suggests that the amplified GPR84 agonist response is achieved through a reactivation of desensitized FPR2s. In addition, the GPR84-mediated FPR2 reactivation was independent of β-arrestin recruitment and sensitive to a protein phosphatase inhibitor. In contrast to FPR2-desensitized cells, FPR1 desensitization primarily resulted in a suppressed GPR84 agonist-induced ROS response, indicating a receptor hierarchical desensitization of GPR84 by FPR1-generated signals. In summary, our data show that the two FPRs in human neutrophils control the NADPH oxidase activity with concomitant ROS production by communicating with GPR84 through different mechanisms. While FPR1 desensitizes GPR84 and by that suppresses the release of ROS induced by GPR84 agonists, amplified ROS release is achieved by GPR84 agonists through reactivation of the desensitized FPR2.
DOI: 10.6084/m9.figshare.14344922.v1
title: Supplementary Material for: The Two Formyl Peptide Receptors Differently Regulate GPR84-Mediated Neutrophil NADPH Oxidase Activity

description: Neutrophils express the two formyl peptide receptors (FPR1 and FPR2) and the medium-chain fatty acid receptor GPR84. The FPRs are known to define a hierarchy among neutrophil G protein-coupled receptors (GPCRs), that is, the activated FPRs can either suppress or amplify GPCR responses. In this study, we investigated the position of GPR84 in the FPR-defined hierarchy regarding the activation of neutrophil nicotine adenine dinucleotide phosphate (NADPH) oxidase, an enzyme system designed to generate reactive oxygen species (ROS), which are important regulators in cell signaling and immune regulation. When resting neutrophils were activated by GPR84 agonists, a modest ROS release was induced. However, vast amounts of ROS were induced by these GPR84 agonists in FPR2-desensitized neutrophils, and the response was inhibited not only by a GPR84-specific antagonist but also by an FPR2-specific antagonist. This suggests that the amplified GPR84 agonist response is achieved through a reactivation of desensitized FPR2s. In addition, the GPR84-mediated FPR2 reactivation was independent of β-arrestin recruitment and sensitive to a protein phosphatase inhibitor. In contrast to FPR2-desensitized cells, FPR1 desensitization primarily resulted in a suppressed GPR84 agonist-induced ROS response, indicating a receptor hierarchical desensitization of GPR84 by FPR1-generated signals. In summary, our data show that the two FPRs in human neutrophils control the NADPH oxidase activity with concomitant ROS production by communicating with GPR84 through different mechanisms. While FPR1 desensitizes GPR84 and by that suppresses the release of ROS induced by GPR84 agonists, amplified ROS release is achieved by GPR84 agonists through reactivation of the desensitized FPR2.
DOI: 10.26180/14344991.v1
title: Data from Senior et al. Journal of Biogeography. Correlates of extinction risk in Australian squamate reptiles

description: Data from Senior et al. Journal of Biogeography. Correlates of extinction risk in Australian squamate reptiles
DOI: 10.26180/14344991
title: Data from Senior et al. Journal of Biogeography. Correlates of extinction risk in Australian squamate reptiles

description: Data from Senior et al. Journal of Biogeography. Correlates of extinction risk in Australian squamate reptiles
DOI: 10.6084/m9.figshare.13019507
title: Metagenome_Summaries

description: This dataset summaries each metagenome used in<i> "Genome-resolved metagenomics suggests a mutualistic relationship between Mycoplasma and salmonid hosts". </i>
DOI: 10.6084/m9.figshare.13019477
title: MAGs: contigs and summary

description: This dataset summaries each metagenome used in<i> "Genome-resolved metagenomics suggests a mutualistic relationship between Mycoplasma and salmonid hosts".</i><br>This link will give access to three novel Mycoplasma MAGs, including a summary generated by Anvi'o/v6.1 and a fasta formatted set of contigs for each MAG.
DOI: 10.6084/m9.figshare.13019477.v1
title: MAGs: contigs and summary

description: This dataset summaries each metagenome used in<i> "Genome-resolved metagenomics suggests a mutualistic relationship between Mycoplasma and salmonid hosts".</i><br>This link will give access to three novel Mycoplasma MAGs, including a summary generated by Anvi'o/v6.1 and a fasta formatted set of contigs for each MAG.
DOI: 10.6084/m9.figshare.13019543
title: Pan Genome Summary

description: This dataset summaries the pangenome used for comparative analysis <i> "Genome-resolved metagenomics suggests a mutualistic relationship between Mycoplasma and salmonid hosts".</i>
DOI: 10.6084/m9.figshare.13019543.v1
title: Pan Genome Summary

description: This dataset summaries the pangenome used for comparative analysis <i> "Genome-resolved metagenomics suggests a mutualistic relationship between Mycoplasma and salmonid hosts".</i>
DOI: 10.6084/m9.figshare.13515977
title: Radar recorded child vital sign dataset and deep learning-based age group classifier for vehicular application

description: Children vital signs data recorded with FMCW radar and a clinical sensor.
DOI: 10.6084/m9.figshare.14114929
title: Regulation of miR-186-YY1 axis by the p53 translational isoform ∆40p53: implications in cell proliferation

description: We have earlier shown that p53-FL and its translational isoform ∆40p53 are differentially regulated. In this study, we have investigated the cellular effect of ∆40p53 regulation on downstream gene expression, specifically miRNAs. Interestingly, ∆40p53 showed antagonistic regulation of miR-186-5p as compared to either p53 alone or a combination of both the isoforms. We have elucidated the miR-186-5p mediated effect of ∆40p53 in cell proliferation. Upon expression of ∆40p53, we observed a significant decrease in YY1 levels, an established target of miR-186-5p, which is involved in cell proliferation. Further assays with anti-miR-186 established the interdependence of ∆40p53− miR-186-5p−YY1− cell proliferation. The results unravel a new dimension toward the understanding of ∆40p53 functions, which seems to regulate cellular fate independent of p53FL.
DOI: 10.6084/m9.figshare.14114929.v1
title: Regulation of miR-186-YY1 axis by the p53 translational isoform ∆40p53: implications in cell proliferation

description: We have earlier shown that p53-FL and its translational isoform ∆40p53 are differentially regulated. In this study, we have investigated the cellular effect of ∆40p53 regulation on downstream gene expression, specifically miRNAs. Interestingly, ∆40p53 showed antagonistic regulation of miR-186-5p as compared to either p53 alone or a combination of both the isoforms. We have elucidated the miR-186-5p mediated effect of ∆40p53 in cell proliferation. Upon expression of ∆40p53, we observed a significant decrease in YY1 levels, an established target of miR-186-5p, which is involved in cell proliferation. Further assays with anti-miR-186 established the interdependence of ∆40p53− miR-186-5p−YY1− cell proliferation. The results unravel a new dimension toward the understanding of ∆40p53 functions, which seems to regulate cellular fate independent of p53FL.
DOI: 10.6084/m9.figshare.14345183.v1
title: Supplementary Material for: Cell-Free DNA and Clinical Characteristics in Patients with Small Intestinal or Pancreatic Neuroendocrine Tumors

description: <b><i>Introduction:</i></b> Neuroendocrine tumors (NETs) are rare and characterized by a heterogeneous clinical course and an unmet need for better prognostic markers. Plasma cell-free DNA (cfDNA) has prognostic value in other malignancies but is not previously investigated in NETs. We studied cfDNA levels in patients with mainly low-grade small intestinal NET ­(siNET) or pancreatic NET (pNET) and evaluated the prognostic potential of cfDNA. <b><i>Materials and Methods:</i></b> We included 70 NET patients, siNET (<i>n</i> = 50) and pNET (<i>n</i> = 20). Plasma cfDNA levels were determined by droplet digital PCR for the <i>beta-2-microglobulin</i> gene every 6 months during a period of 3 years, including in a subgroup of 19 patients during peptide receptor radionuclide therapy (PRRT) therapy. <b><i>Results:</i></b> cfDNA levels were higher in both siNET and pNET compared to a previously established healthy cohort (<i>p</i> &lt; 0.0001). ­cfDNA levels did not predict overall survival (crude hazard ratio [HR] 0.95 [0.57–1.58], <i>p</i> = 0.837, adjusted for smoking status HR 0.77 [0.51–1.17], <i>p</i> = 0.22). The impact of cfDNA level on progression-free survival showed different trends in siNET and pNET. There was no effect of PRRT treatment on cfDNA levels and no difference in cfDNA levels between patients with and without progressive disease after PRRT (ANOVA <i>p</i> = 0.66). cfDNA levels were significantly higher in never-smokers and previous smokers than in current smokers (<i>p</i> = 0.029). <b><i>Discussion/Conclusion:</i></b> cfDNA levels are higher in NET patients than in healthy controls; however, there was no association with prognosis, and cfDNA levels were unaffected by PRRT. Our observations suggest that cfDNA levels are not associated with the disease course in low-grade NET in contrast to other malignancies.
DOI: 10.6084/m9.figshare.14345183
title: Supplementary Material for: Cell-Free DNA and Clinical Characteristics in Patients with Small Intestinal or Pancreatic Neuroendocrine Tumors

description: <b><i>Introduction:</i></b> Neuroendocrine tumors (NETs) are rare and characterized by a heterogeneous clinical course and an unmet need for better prognostic markers. Plasma cell-free DNA (cfDNA) has prognostic value in other malignancies but is not previously investigated in NETs. We studied cfDNA levels in patients with mainly low-grade small intestinal NET ­(siNET) or pancreatic NET (pNET) and evaluated the prognostic potential of cfDNA. <b><i>Materials and Methods:</i></b> We included 70 NET patients, siNET (<i>n</i> = 50) and pNET (<i>n</i> = 20). Plasma cfDNA levels were determined by droplet digital PCR for the <i>beta-2-microglobulin</i> gene every 6 months during a period of 3 years, including in a subgroup of 19 patients during peptide receptor radionuclide therapy (PRRT) therapy. <b><i>Results:</i></b> cfDNA levels were higher in both siNET and pNET compared to a previously established healthy cohort (<i>p</i> &lt; 0.0001). ­cfDNA levels did not predict overall survival (crude hazard ratio [HR] 0.95 [0.57–1.58], <i>p</i> = 0.837, adjusted for smoking status HR 0.77 [0.51–1.17], <i>p</i> = 0.22). The impact of cfDNA level on progression-free survival showed different trends in siNET and pNET. There was no effect of PRRT treatment on cfDNA levels and no difference in cfDNA levels between patients with and without progressive disease after PRRT (ANOVA <i>p</i> = 0.66). cfDNA levels were significantly higher in never-smokers and previous smokers than in current smokers (<i>p</i> = 0.029). <b><i>Discussion/Conclusion:</i></b> cfDNA levels are higher in NET patients than in healthy controls; however, there was no association with prognosis, and cfDNA levels were unaffected by PRRT. Our observations suggest that cfDNA levels are not associated with the disease course in low-grade NET in contrast to other malignancies.
DOI: 10.5281/zenodo.4647953
title: Gut Vascular Barrier impairment leads to intestinal bacteria dissemination and colorectal cancer metastasis to liver

description: Code imaging related to<strong> Gut Vascular Barrier impairment leads to intestinal bacteria dissemination and colorectal cancer metastasis to liver</strong>
DOI: 10.5281/zenodo.4560401
title: Gut Vascular Barrier impairment leads to intestinal bacteria dissemination and colorectal cancer metastasis to liver

description: Code imaging related to<strong> Gut Vascular Barrier impairment leads to intestinal bacteria dissemination and colorectal cancer metastasis to liver</strong>
DOI: 10.6084/m9.figshare.14345351
title: Supplementary Material for: A Thermally Stable Protein EPP1 of Corn Borer <b><i>Ostrinia furnacalis</i></b> Regulates Hemocytic Encapsulation

description: Encapsulation is a vital cellular immune reaction of host insects against endoparasitoids; however, how encapsulation is regulated is still unclear. Utilizing a cell line, SYSU-<i>Of</i>Hem C, derived from larval hemocytes of the Asian corn borer <i>Ostrinia furnacalis</i> to assay for encapsulation response<i>,</i> an encapsulation-promoting protein (<i>Of</i>EPP1) was isolated from the plasma of <i>O. furnacalis</i> larvae. <i>Of</i>EPP1 is a novel secretory protein, which exists only in <i>O. furnacalis</i> to date. The <i>OfEpp1</i> gene is intronless and encodes a protein containing several groups of short repetitive sequences and a high proportion of proline residues (18.3%). <i>Of</i>EPP1 is a thermally stable protein that is mainly expressed in fat bodies, and its accumulation could be induced by the injection of foreign objects (Sephadex beads). Eukaryotically expressed recombinant <i>Of</i>EPP1 promoted hemocytes to encapsulate Sephadex beads, while prokaryotically expressed protein did not, indicating that posttranscriptional modification affects the function of <i>Of</i>EPP1. The encapsulation-promoting function of <i>Of</i>EPP1 could be neutralized by the addition of polyclonal antibodies against <i>Of</i>EPP1 or disrupted by the injection of dsRNA targeting <i>OfEpp1.</i> Eukaryotically expressed <i>Of</i>EPP1 promoted the aggregation, but not spreading, of both granulocytes and plasmatocytes. Immunocytochemistry analysis showed that eukaryotically expressed <i>Of</i>EPP1 could bind to the surface of hemocytes. Therefore, we speculate that <i>Of</i>EPP1 possibly promotes hemocytic encapsulation by binding to the surface of hemocytes as a ligand to induce their aggregation. This study provides evidence clarifying the mechanism of encapsulation in insects.
DOI: 10.6084/m9.figshare.14345342
title: Supplementary Material for: Effect of Peer Mentoring on Quality of Life among CKD Patients: Randomized Controlled Trial

description: <b><i>Introduction:</i></b> CKD is associated with decreased quality of life (QOL). Peer mentoring (PM) leads to improved QOL in various chronic diseases. The effectiveness of PM on QOL of patients with CKD has not been previously studied. We conducted a randomized clinical trial to test the effectiveness of face-to-face (FTF) and online mentoring by trained peers, compared with usual care, on CKD patients’ QOL. <b><i>Methods:</i></b> We randomized 155 patients in one of 3 groups: (1) FTF PM (<i>n</i> = 52), (2) online PM (<i>n</i> = 52), and (3) textbook only (<i>n</i> = 51). Peer mentors were patients with CKD, who received formal training through 16 h of instruction. Participants in all 3 groups received a copy of an informational textbook about CKD. Participants assigned to PM received either 6 months of FTF or online PM. The outcomes included time-related changes in domain scores of the Kidney Disease Quality of Life (KDQOL)-36 for each of the groups over the 18-month study period. <b><i>Results:</i></b> Compared with baseline, online PM led to improved scores in domains of the KDQOL-36 at 18 months: Effects of Kidney Disease (<i>p</i> = 0.01), Burden of Kidney Disease (<i>p</i> = 0.01), Symptoms and Problems of Kidney Disease (<i>p</i> = 0.006), SF-12 Physical Composite Summary (<i>p</i> = 0.001), and SF-12 Mental Composite Summary (<i>p</i> &lt; 0.001). There were no statistically significant changes from baseline in domain scores of KDQOL-36 within the FTF PM and textbook-only groups. <b><i>Conclusions:</i></b> Among patients with CKD, online PM led to increased scores in domains of the KDQOL-36 at 18 months. The study was limited to English-speaking subjects with computer literacy and internet access.
DOI: 10.26066/rds.1972554
title: Snow Water Equivalent Station at Yala Basecamp

description: Gamma Ray Station close to Yala Basecamp measuring Snow Water Equivalent as well as radiation (shortwave and longwave radiation) and distance to surface/snow depth
DOI: 10.26066/rds.1972547
title: Eddy Covariance Station Lirung Glacier

description: Eddy Covariance Station measuring turbulent fluxes on Lirung Glacier over approximately 16 days in October 2016.
DOI: 10.26066/rds.1972553
title: GST (Ground surface temperature) loggers Langtang Valley

description: Collection of ground surface temperaure loggers (39) placed on the Yala Plateau on different surface types.
DOI: 10.26066/rds.1972570
title: Habitat suitability data for the Clouded Leopard

description: The Hindu Kush Himalayan region (HKH) is an important biodiversity hotspot with more than 488 protected areas covering 39% of the region's geographical coverage. A majority of the protected areas are small and isolated and are not large enough to address conservation challenges. Only about 20% of the protected areas are transboundary in nature. There is limited data available on habitat suitability for conservation planning and landscape management in the Far Eastern Himalayan Landscape. A study carried out under the Landscape Initiative for Far Eastern Himalayas (HI-LIFE) Initiative at ICIMOD, estimates habitat suitability for the Clouded Leopard in the Far Eastern Himalayas using remote sensing and geographic information system tools, and available secondary information.
DOI: 10.26066/rds.1972571
title: Habitat suitability data for the Badger

description: The Hindu Kush Himalayan region (HKH) is an important biodiversity hotspot with more than 488 protected areas covering 39% of the region's geographical coverage. A majority of the protected areas are small and isolated and are not large enough to address conservation challenges. Only about 20% of the protected areas are transboundary in nature. There is limited data available on habitat suitability for conservation planning and landscape management in the Far Eastern Himalayan Landscape. A study carried out under the Landscape Initiative for Far Eastern Himalayas (HI-LIFE) Initiative at ICIMOD, estimates habitat suitability for the Badger in the Far Eastern Himalayas using remote sensing and geographic information system tools, and available secondary information.
DOI: 10.26066/rds.1972573
title: Habitat suitability data for the Western hoolock gibbon

description: The Hindu Kush Himalayan region (HKH) is an important biodiversity hotspot with more than 488 protected areas covering 39% of the region's geographical coverage. A majority of the protected areas are small and isolated and are not large enough to address conservation challenges. Only about 20% of the protected areas are transboundary in nature. There is limited data available on habitat suitability for conservation planning and landscape management in the Far Eastern Himalayan Landscape. A study carried out under the Landscape Initiative for Far Eastern Himalayas (HI-LIFE) Initiative at ICIMOD, estimates habitat suitability for the Western hoolock gibbon in the Far Eastern Himalayas using remote sensing and geographic information system tools, and available secondary information.
DOI: 10.26066/rds.1972574
title: Habitat suitability data for the Sambar deer

description: The Hindu Kush Himalayan region (HKH) is an important biodiversity hotspot with more than 488 protected areas covering 39% of the region's geographical coverage. A majority of the protected areas are small and isolated and are not large enough to address conservation challenges. Only about 20% of the protected areas are transboundary in nature. There is limited data available on habitat suitability for conservation planning and landscape management in the Far Eastern Himalayan Landscape. A study carried out under the Landscape Initiative for Far Eastern Himalayas (HI-LIFE) Initiative at ICIMOD, estimates habitat suitability for the Sambar deer in the Far Eastern Himalayas using remote sensing and geographic information system tools, and available secondary information.
DOI: 10.26066/rds.1972575
title: Habitat suitability data for the Myanmar snubnosed monkey

description: The Hindu Kush Himalayan region (HKH) is an important biodiversity hotspot with more than 488 protected areas covering 39% of the region's geographical coverage. A majority of the protected areas are small and isolated and are not large enough to address conservation challenges. Only about 20% of the protected areas are transboundary in nature. There is limited data available on habitat suitability for conservation planning and landscape management in the Far Eastern Himalayan Landscape. A study carried out under the Landscape Initiative for Far Eastern Himalayas (HI-LIFE) Initiative at ICIMOD, estimates habitat suitability for the Myanmar snubnosed monkey in the Far Eastern Himalayas using remote sensing and geographic information system tools, and available secondary information.
DOI: 10.26066/rds.1972576
title: Habitat suitability data for the Eastern hoolock gibbon

description: The Hindu Kush Himalayan region (HKH) is an important biodiversity hotspot with more than 488 protected areas covering 39% of the region's geographical coverage. A majority of the protected areas are small and isolated and are not large enough to address conservation challenges. Only about 20% of the protected areas are transboundary in nature. There is limited data available on habitat suitability for conservation planning and landscape management in the Far Eastern Himalayan Landscape. A study carried out under the Landscape Initiative for Far Eastern Himalayas (HI-LIFE) Initiative at ICIMOD, estimates habitat suitability for the Eastern hoolock gibbon in the Far Eastern Himalayas using remote sensing and geographic information system tools, and available secondary information.
DOI: 10.6084/m9.figshare.13655276.v3
title: Materials Informatics Platform with Three-Dimensional Structures - Workflow and Thermoelectric Applications

description: We present a large dataset of 3D materials. with more than 30,000 entries in the database, which contain the relaxed crystal structures, density of states, and band structures. Calculation of the equations of state and sound velocities is performed for over 12,000 entries. The electrical transport properties for approximately 4,400 entries are also calculated.