cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.7185698
title: Pharmacokinetic of florfenicol in pulmonary epithelial lining fluid of swine and effects of anesthetic agent on drug plasma disposition kinetics

description: ABSTRACT The primary objective of the current study was to compare the pharmacokinetic (PK) of florfenicol (FFL) in pulmonary epithelial lining fluid and the plasma in swine. The second objectives were to evaluate the effect of anesthesia with ketamine and propofol on the PK of FFL in plasma. Bronchoaveolar lavage was utilized for quantification of PELF volume and the urea dilution method was used to determine the concentration of FFL in PELF. FFL was administered intramuscularly (IM) to swine in a single dose of 20mg/kg body weight. The main PK parameters of FFL in plasma and PELF were as follows: the area under the concentration-time curve, maximal drug concentration, elimination half-life and mean residence time were 69.45±4.36 vs 85.03±9.26μg·hr/ml, 4.65±0.34 vs 5.94±0.86μg/ml, 9.87±1.70 vs 10.69±1.60hr and 12.75±0.35 vs 14.46±1.26hr, respectively. There was no statistically significant difference between the PK profiles of FFL for the anesthetized and unanesthetized pigs. This study suggest that (i) FFL penetrated rapidly into the pulmonary and the drug concentration decay faster in plasma than in the pulmonary, (ii) the PK profile of FFL in swine was not interfered after administration of anesthetic agent.
DOI: 10.6084/m9.figshare.7185728
title: SELECTIVE CHLORINATION OF GLYCEROL TO 3-CHLORO-1,2-PROPANEDIOL CATALYZED BY BRØNSTED ACIDIC IONIC LIQUIDS

description: Abstract Brønsted acidic ionic liquids composed of 1-butyl-3-methylimidazolium, triethylbutylammonium, and 1-butylpyridinium cation counterparts and HSO4‾ and H2PO4‾ anion counterparts were used as the catalysts for the selective chlorination of glycerol with hydrogen chloride to 3-chloro-1,2-propandiol. From the perspective of the glycerol conversion and product yields, the catalytic activities of the ionic liquids containing HSO4‾ were higher than the ionic liquids containing H2PO4‾. As compared with the carboxylic acid catalysts, Brønsted acidic ionic liquids favored the catalytic chlorination of glycerol to 3-chloro-1,2-propandiol. When the glycerol chlorination was catalyzed by the Brønsted acidic ionic liquids at 110 ºC for 12 h with the catalyst loading of 0.75 mol·kg‾1 glycerol, the 3-chloro-1,2-propandiol yield was more than 81% at the complete conversion of glycerol.
DOI: 10.6084/m9.figshare.19768132.v1
title: Additional file 3 of A TetR family transcriptional regulator, SP_2854 can affect the butenyl-spinosyn biosynthesis by regulating glucose metabolism in Saccharopolyspora pogona

description: Additional file 3: DataSet S2. Comparative proteomic analysis of the S. pogona::SP_2854 mutant and S. pogona at 6th day.
DOI: 10.6084/m9.figshare.19768135.v1
title: Additional file 4 of A TetR family transcriptional regulator, SP_2854 can affect the butenyl-spinosyn biosynthesis by regulating glucose metabolism in Saccharopolyspora pogona

description: Additional file 4: DataSet S3. Differentially expressed proteins analysis of the S. pogona::SP_2854 mutant and wild-type S. pogona at 6th day.
DOI: 10.6084/m9.figshare.7185482.v1
title: Determination of Estrogens in Milk Using Polypyrrole Fiber-Mediated Solid-Phase Extraction Followed by High Performance Liquid Chromatography

description: A solid-phase extraction (SPE) method based on conductive polypyrrole (PPy) nanofibers which were fabricated by electrospinning and in situ polymerization was developed. PPy nanofibers-mediated SPE followed by high performance liquid chromatography (HPLC) was used for the determination of three synthetic estrogens, namely diethylstilbestrol (DES), dienestrol (DIS), or hexestrol (HS) in milk sample. Extraction conditions including extraction nanofibers, donor solution pH and salt concentration were optimized. The target compounds were extracted from a 0.5 mL aqueous sample at pH 5.0 through PPy fibers, and then were eluted with 0.1 mL methanol. After extraction, the eluant was directly injected into an HPLC system for detection. Under the optimized extraction conditions, a large enrichment factor was achieved for three estrogens. The limit of detection (LOD) at a signal to noise ratio (S/N) of 3 ranged from 0.02 to 0.05 µg mL-1 for the estrogens in milk sample.
DOI: 10.6084/m9.figshare.8240231
title: Additional file 3: of TaAMT2;3a, a wheat AMT2-type ammonium transporter, facilitates the infection of stripe rust fungus on wheat

description: Table S1. List of names, accession ID and protein sequences of ammonium transporters genes analyzed in this study. (XLSX 15 kb)
DOI: 10.6084/m9.figshare.8240231.v1
title: Additional file 3: of TaAMT2;3a, a wheat AMT2-type ammonium transporter, facilitates the infection of stripe rust fungus on wheat

description: Table S1. List of names, accession ID and protein sequences of ammonium transporters genes analyzed in this study. (XLSX 15 kb)
DOI: 10.6084/m9.figshare.13476911
title: Investigating the intention to purchase virtual goods in social networking service games: a self-presentation perspective

description: With the rising popularity of SNS games, virtual goods are expected to generate revenue for game providers. However, previous findings may be at odds with changes in this new virtual environment, while some social platforms lack understanding of what motivates users to purchase virtual goods in SNS games either. Considering the social nature of SNS games, this study adopted the self-presentation theory to explore these factors. A conceptual model was proposed and subsequently empirically tested with 302 samples collected from the questionnaire survey. The results show that the desire for online self-presentation is significantly influenced by SNS games involvement, online self-presentation norms, interactivity, and perceived usability. The results also indicate that the effect of the desire for online self-presentation on intention to purchase virtual goods is significant. In addition, the moderated role of perceived usability on the relationship between interactivity and the desire for online self-presentation is established as well. Our findings contribute to the literature on SNS games as well as self-presentation. It also lends insights into how SNS providers can tap this source of revenue.
DOI: 10.6084/m9.figshare.7185482
title: Determination of Estrogens in Milk Using Polypyrrole Fiber-Mediated Solid-Phase Extraction Followed by High Performance Liquid Chromatography

description: A solid-phase extraction (SPE) method based on conductive polypyrrole (PPy) nanofibers which were fabricated by electrospinning and in situ polymerization was developed. PPy nanofibers-mediated SPE followed by high performance liquid chromatography (HPLC) was used for the determination of three synthetic estrogens, namely diethylstilbestrol (DES), dienestrol (DIS), or hexestrol (HS) in milk sample. Extraction conditions including extraction nanofibers, donor solution pH and salt concentration were optimized. The target compounds were extracted from a 0.5 mL aqueous sample at pH 5.0 through PPy fibers, and then were eluted with 0.1 mL methanol. After extraction, the eluant was directly injected into an HPLC system for detection. Under the optimized extraction conditions, a large enrichment factor was achieved for three estrogens. The limit of detection (LOD) at a signal to noise ratio (S/N) of 3 ranged from 0.02 to 0.05 µg mL-1 for the estrogens in milk sample.
DOI: 10.6084/m9.figshare.19768135
title: Additional file 4 of A TetR family transcriptional regulator, SP_2854 can affect the butenyl-spinosyn biosynthesis by regulating glucose metabolism in Saccharopolyspora pogona

description: Additional file 4: DataSet S3. Differentially expressed proteins analysis of the S. pogona::SP_2854 mutant and wild-type S. pogona at 6th day.
DOI: 10.6084/m9.figshare.25250596
title: Resistome diversity values for oropharyngeal and fecal samples

description: A table of resistome diversity values for oropharyngeal and fecal samples calculated as the number of AR genes that have at least one gene variant fully covered with reads
DOI: 10.6084/m9.figshare.25250596.v1
title: Resistome diversity values for oropharyngeal and fecal samples

description: A table of resistome diversity values for oropharyngeal and fecal samples calculated as the number of AR genes that have at least one gene variant fully covered with reads
DOI: 10.6084/m9.figshare.7185698.v1
title: Pharmacokinetic of florfenicol in pulmonary epithelial lining fluid of swine and effects of anesthetic agent on drug plasma disposition kinetics

description: ABSTRACT The primary objective of the current study was to compare the pharmacokinetic (PK) of florfenicol (FFL) in pulmonary epithelial lining fluid and the plasma in swine. The second objectives were to evaluate the effect of anesthesia with ketamine and propofol on the PK of FFL in plasma. Bronchoaveolar lavage was utilized for quantification of PELF volume and the urea dilution method was used to determine the concentration of FFL in PELF. FFL was administered intramuscularly (IM) to swine in a single dose of 20mg/kg body weight. The main PK parameters of FFL in plasma and PELF were as follows: the area under the concentration-time curve, maximal drug concentration, elimination half-life and mean residence time were 69.45±4.36 vs 85.03±9.26μg·hr/ml, 4.65±0.34 vs 5.94±0.86μg/ml, 9.87±1.70 vs 10.69±1.60hr and 12.75±0.35 vs 14.46±1.26hr, respectively. There was no statistically significant difference between the PK profiles of FFL for the anesthetized and unanesthetized pigs. This study suggest that (i) FFL penetrated rapidly into the pulmonary and the drug concentration decay faster in plasma than in the pulmonary, (ii) the PK profile of FFL in swine was not interfered after administration of anesthetic agent.
DOI: 10.6084/m9.figshare.19768555
title: LncRNA NEAT1 affects endometrial receptivity by regulating HOXA10 promoter activity

description: <i>In vitro</i> fertilization and embryo transfer (IVF-ET) is one of the effective methods to treat female infertility. Poor endometrial receptivity (ER) is an important factor leading to embryo implantation dysfunction, which can reduce pregnancy rate of IVF-ET. The mice model with embryo implantation dysfunction <i>in vivo</i> and attachment model of trophoblast (JAR) spheroids <i>in vitro</i> were constructed. The levels of lncRNA NEAT1, HOXA10, CTCF and markers of ER were detected. The cell proliferation was measured. The interaction between lncRNA NEAT1 and CTCF, HOXA10 promoter and CTCF were confirmed. LncRNA NEAT1 and HOXA10 levels in infertile patients and mice model with embryo implantation dysfunction were increased. <i>In vitro</i> experiments showed that down-regulation of lncRNA NEAT1 improved EECs proliferation and ER marker expressions. LncRNA NEAT1 could bind to CTCF, and CTCF could bind to HOXA10 promoter and down-regulate HOXA10 gene expression by regulating histone modification level. The lncRNA NEAT1/CTCF/HOXA10 signaling pathway regulated EECs proliferation and ER establishment <i>in vitro</i> and <i>in vivo</i>. Our study suggested that lncRNA NEAT1 could up-regulate HOXA10 promoter activity and its expression by combining with CTCF, thus improving EECs proliferation and ER establishment, and ultimately facilitating embryo implantation.
DOI: 10.6084/m9.figshare.13476867
title: Metadata record for the manuscript: Urban Access Across the Globe: An International Comparison of Different Transport Modes

description: <b>Summary</b>

This
metadata record provides details of the data supporting the claims of the
related manuscript: “Urban Access Across the Globe: An
International Comparison of Different Transport Modes ”.

The
related study examines the relationship between population-weighted access (the
ease of reaching valued destinations) and metropolitan population in global
metropolitan areas (cities).

 

Type of data:
access, calculated as the cumulative number of jobs reachable under a 30-minute
travel time threshold

Subject of
data: 117 cities from 16 countries and 6 continents

 

<b>Data
access</b>

The access
data are openly available as part of this <i>figshare
</i>metadata record in the file ‘AllCities.csv. A list of all cities included
in the study, along with the sources of the data used for each city, is
available in the file ‘SI for Urban Access Across the Globe-An International
Comparison of Different Transport Modes.pdf’. Both of these files are also
available in PDF format via the Supplementary Information of the related
article.

 

<b>Corresponding author(s) for this study</b>

Hao
Wu, School of Civil Engineering, University of Sydney, h.wu@sydney.edu.au.
DOI: 10.6084/m9.figshare.16620862
title: Additional file 1 of Construction and investigation of a circRNA-associated ceRNA regulatory network in Tetralogy of Fallot

description: Additional file 1. Table 1 Differentially expressed circRNAs between the TOF group and the healthy control group.
DOI: 10.21227/pcvh-0j22
title: Simulated aircraft trajectory for theoretical velocity ranking

description: This data set is a data set used for aircraft theoretical velocity ranking. Four sensors are randomly arranged in a 1*1 square map, and three aircraft will fly over the map coverage area at the same time. The velocity of the aircraft is simulated by a random process. The theoretical velocities of the three aircraft are similar, and the velocity of the aircraft will be disturbed during actual flight, causing large fluctuations, so that it is difficult to distinguish the theoretical velocity order of the aircraft flying into the map. The coverage area of the sensor is circular with a fixed radius. The four sensors have a unified detection interval event and will detect the position of the aircraft within the coverage area with unified accuracy. The target task is to reason the theoretical velocity ranking of three aircraft through the trajectory data collected by the sensors.
DOI: 10.6084/m9.figshare.8240417
title: Additional file 1: of A novel lncRNA-miRNA-mRNA triple network identifies lncRNA TWF1 as an important regulator of miRNA and gene expression in coronary artery disease

description: Table S1. PCR primers for quantitative real-time PCR. Table S2. Differentially expressed mRNAs (DEGs). Table S3. Differentially expressed miRNAs (DEMis). Table S4. Differentially expressed lncRNAs (DELs). (XLSX 113 kb)
DOI: 10.6084/m9.figshare.25017767
title: Additional file 1 of Protein profiling in systemic sclerosis patients with different pulmonary complications using proteomic antibody microarray

description: Additional file 1. Serum samples from 15 patients with SSc and five HCs.
DOI: 10.6084/m9.figshare.25017767.v1
title: Additional file 1 of Protein profiling in systemic sclerosis patients with different pulmonary complications using proteomic antibody microarray

description: Additional file 1. Serum samples from 15 patients with SSc and five HCs.
DOI: 10.34740/kaggle/ds/4469109
title: 2024's Most-Watched YouTube Videos 📈
DOI: 10.6084/m9.figshare.13476732.v1
title: Metadata record for the manuscript: Characterization of evolution trajectory and immune profiling of brain metastasis in lung adenocarcinoma

description: <b>Summary</b>

This
metadata record provides details of the data supporting the claims of the
related manuscript: “Characterization of evolution
trajectory and immune profiling of brain metastasis in lung adenocarcinoma”.

The
related study aimed to characterise the evolutionary trajectory and immune
profiling of brain metastasis (BM), towards providing insights into the
development of novel therapeutic strategies.

 

Type of data:
whole exome sequencing, multiplex immunofluorescence 

Subject of
data: samples from lung adenocarcinoma (LUAD) patients with BM and their paired
primary tumours

Sample size:
40 samples from 12 LUAD patients

Recruitment:
Patients with histologically or pathologically diagnosed lung cancer and
radiologically (CT and/or MRI) or pathologically confirmed brain metastasis
were recruited. Primary lung cancers, matched brain metastasis and peripheral
blood were collected.

 

<b><br></b><b>Data
access</b>

The whole
exome sequencing data are openly available in the <i>NCBI Sequence Read Archive</i> via the following accession: https://identifiers.org/ncbi/insdc.sra:SRP170084.
These data underlie Figures 2, 3 and 4 in the related article. Additionally,
the Supplementary Material file is available as part of this metadata record
as well as with the article itself. This Supplementary Material file contains
data associated with Figures 2, 3, 5 and 6 in the related article. 

 

<b><br></b><b>Corresponding author(s) for this study</b>

Prof.
Caicun Zhou, M.D., Ph.D., Department of Medical Oncology, Shanghai Pulmonary
Hospital & Thoracic Cancer Institute, Tongji University School of Medicine,
No. 507, Zheng Min Road, Shanghai, 200433, P.R. China. Tel: +86-21-65115006;
Fax +86-21-65111298; E-mail: caicunzhou_dr@163.com.

Prof.
Jun Zhang, M.D., Ph.D., Division of Medical Oncology, Department of Internal Medicine;
Department of Cancer Biology, University of Kansas Cancer Center; University of
Kansas Medical Center, Kansas City, KS 66160, USA. Tel: +1 (913) 588-8150; Fax
+1 (913) 588-4085; E-mail: jzhang3@kumc.edu.

Prof.
Jie Lin, M.D., Ph.D., Department of Oncology, The Second Affiliated Hospital of
Kunming Medical University, No. 377, Dianmian Road, Kunming, 650101, P.R.
China. Tel: +86-0871-65351281; Fax +86-0871-65361017; E-mail: linjieshi@126.com.

<br>
<b>Study approval </b>

The
study protocol was approved by the Institutional Review Board of Shanghai
Pulmonary Hospital, Tongji University School of Medicine (No. 2015-0709).
Written informed consent was obtained from all participants. The study was
conducted in accordance with the Declaration of Helsinki.
DOI: 10.6084/m9.figshare.13476867.v1
title: Metadata record for the manuscript: Urban Access Across the Globe: An International Comparison of Different Transport Modes

description: <b>Summary</b>

This
metadata record provides details of the data supporting the claims of the
related manuscript: “Urban Access Across the Globe: An
International Comparison of Different Transport Modes ”.

The
related study examines the relationship between population-weighted access (the
ease of reaching valued destinations) and metropolitan population in global
metropolitan areas (cities).

 

Type of data:
access, calculated as the cumulative number of jobs reachable under a 30-minute
travel time threshold

Subject of
data: 117 cities from 16 countries and 6 continents

 

<b>Data
access</b>

The access
data are openly available as part of this <i>figshare
</i>metadata record in the file ‘AllCities.csv. A list of all cities included
in the study, along with the sources of the data used for each city, is
available in the file ‘SI for Urban Access Across the Globe-An International
Comparison of Different Transport Modes.pdf’. Both of these files are also
available in PDF format via the Supplementary Information of the related
article.

 

<b>Corresponding author(s) for this study</b>

Hao
Wu, School of Civil Engineering, University of Sydney, h.wu@sydney.edu.au.
DOI: 10.6084/m9.figshare.19768555.v1
title: LncRNA NEAT1 affects endometrial receptivity by regulating HOXA10 promoter activity

description: <i>In vitro</i> fertilization and embryo transfer (IVF-ET) is one of the effective methods to treat female infertility. Poor endometrial receptivity (ER) is an important factor leading to embryo implantation dysfunction, which can reduce pregnancy rate of IVF-ET. The mice model with embryo implantation dysfunction <i>in vivo</i> and attachment model of trophoblast (JAR) spheroids <i>in vitro</i> were constructed. The levels of lncRNA NEAT1, HOXA10, CTCF and markers of ER were detected. The cell proliferation was measured. The interaction between lncRNA NEAT1 and CTCF, HOXA10 promoter and CTCF were confirmed. LncRNA NEAT1 and HOXA10 levels in infertile patients and mice model with embryo implantation dysfunction were increased. <i>In vitro</i> experiments showed that down-regulation of lncRNA NEAT1 improved EECs proliferation and ER marker expressions. LncRNA NEAT1 could bind to CTCF, and CTCF could bind to HOXA10 promoter and down-regulate HOXA10 gene expression by regulating histone modification level. The lncRNA NEAT1/CTCF/HOXA10 signaling pathway regulated EECs proliferation and ER establishment <i>in vitro</i> and <i>in vivo</i>. Our study suggested that lncRNA NEAT1 could up-regulate HOXA10 promoter activity and its expression by combining with CTCF, thus improving EECs proliferation and ER establishment, and ultimately facilitating embryo implantation.
DOI: 10.57992/nmrxiv.p55
title: Antimicrobial Prenylated Isoflavones from the Leaves of the Amazonian Medicinal Plant Vatairea guianensis Aubl.
DOI: 10.6084/m9.figshare.19768099.v1
title: Additional file 8 of Epigenetic regulation of innate immune memory in microglia

description: Additional file 8: Genes and associated gene ontology terms for each cluster identified in the priming mouse model (related to Figs. 2 and S3).
DOI: 10.6084/m9.figshare.7185953
title: MOLECULAR DESCRIPTION OF COPPER (I) OXIDE AND COPPER (II) OXIDE

description: The topological index of a molecular structure correlate certain physicochemical properties such as boiling point and stability of that molecular structure. Recently several topological indices have been introduced and studies have shown their association with certain physical and chemical properties of other molecules. Specifically, Zagreb, Atom-bound connectivity (ABC) and Sanskruti indices have been correlated with extent of branching, enthalpy and entropy of some organic molecules. In this study we have calculated Zagreb, Atom-bound connectivity (ABC) and Sanskruti indices (S) for Copper (I) oxide and Copper (II) oxide CuO. Additionally, from the experimentally available data, we calculated entropy and enthalpy per unit cell for both the oxides and compared with Atom-bound connectivity and Sanskruti indices. It appears that these indices have very poor relation with these physical properties in both oxides of copper and they may need some modifications to show considerable compliance as reported in other organic molecules."
DOI: 10.6084/m9.figshare.5612881
title: Recycling of palaeo-Pacific subducted oceanic crust related to a Fe–Cu–Au mineralization in the Xu-Huai region of North Anhui-Jiangsu, East China: Geochronological and geochemical constraints

description: In this study, Early Cretaceous skarn deposits and genesis of their host diorite/monzodiorite porphyry in the Xuzhou-Huaibei (Xu-Huai) region, northern Anhui-Jiangsu have been discussed by detailed geochemical work. In-situ zircon U–Pb dating of the diorites related to Fe–Cu–Au deposits shows that they were formed between 131.4 ± 1.5 Ma and 130.8 ± 1.8 Ma. Geochemical data indicate a depletion of high field strength elements (HFSE) in the diorite porphyry with similarity to that of arc-related igneous rocks. The diorite porphyry was probably derived from typical arc magmas related to continental margin subduction characterized by light rare earth elements (LREEs) enrichment and HFSE depletion. REEs compositions of apatite in the diorite porphyry indicate that the dioritic magma was produced from the metasomatized subcontinental mantle by slab-derived fluids. The magma was proven to be a high oxygen fugacity; thus, it was particularly conducive to the precipitation of Fe, Cu, Au and other ore-forming elements. The δ<sup>34</sup>S values of pyrite and chalcopyrite of Fe–Cu–Au ores range from −0.2‰ to 2.8‰, indicating that the sulphur in the ore was probably derived from deep-seated magmas. Integrated with geochronological and geochemical analyses, we suggest that the Early Cretaceous igneous suites associated with Fe–Cu–Au deposits in the Xu-Huai region are related to recycling subduction of Pacific oceanic crust.