cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.7130951.v1
title: Effects of different drying methods on the bioactive compounds and antioxidant properties of edible Centaurea (Centaurea cyanus) petals

description: Abstract The present study aimed to evaluate the effects of hot-air convective drying, shade drying and freeze-drying on the bioactive compounds and antioxidant activity of Centaurea ( Centaurea cyanus L.) petals, as well as on several of their physicochemical properties. All the dried samples showed different appearances as compared to fresh petals, with lower titratable acidity, lower carotenoids and hydrolysable tannins contents, and greater antioxidant activity. Of the drying methods, shade drying presented the highest values for monomeric anthocyanins, flavonoids, hydrolysable tannins, total reducing capacity and antioxidant activity. By contrast, greater losses were observed as a result of hot-air convective drying. Thus shade drying is a highly promising process that should be considered as a suitable drying method for Centaurea petals.
DOI: 10.7284/110011
title: Multibeam Echosounder data collected during research cruise ZHNG09RR using a Kongsberg EM120 instrument system onboard the platform RV Roger Revelle

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7130945
title: Effect of different solutions on color stability of acrylic resin-based dentures

description: The aim of this study was to evaluate the effect of thermocycling and immersion in mouthwash or beverage solutions on the color stability of four different acrylic resin-based dentures (Onda Cryl, OC; QC20, QC; Classico, CL; and Lucitone, LU). The factors evaluated were type of acrylic resin, immersion time, and solution (mouthwash or beverage). A total of 224 denture samples were fabricated. For each type of resin, eight samples were immersed in mouthwashes (Plax-Colgate, PC; Listerine, LI; and Oral-B, OB), beverages (coffee, CP; cola, C; and wine, W), and artificial saliva (AS; control). The color change (DE) was evaluated before (baseline) and after thermocycling (T1), and after immersion in solution for 1 h (T2), 3 h (T3), 24 h (T4), 48 h (T5), and 96 h (T6). The CIE Lab system was used to determine the color changes. The thermocycling test was performed for 5000 cycles. Data were submitted to three-way repeated-measures analysis of variance and Tukey's test (p &lt; 0.05). When the samples were immersed in each mouthwash, all assessed factors, associated or not, significantly influenced the color change values, except there was no association between the mouthwash and acrylic resin. Similarly, when the samples were immersed in each beverage, all studied factors influenced the color change values. In general, regardless of the solution, LU exhibited the greatest DE values in the period from T1 to T5; and QC presented the greatest DE values at T6. Thus, thermocycling and immersion in the various solutions influenced the color stability of acrylic resins and QC showed the greatest color alteration.
DOI: 10.6084/m9.figshare.7130948
title: Effectiveness of rotatory and reciprocating movements in root canal filling material removal

description: The purpose of this study was to compare the efficacy of reciprocating and rotary techniques for removing gutta-percha and sealer from root canals. Forty straight and oval single-rooted premolars were prepared up to size 30, filled with gutta-percha and sealer, and then randomly allocated to two experimental retreatment groups: ProTaper Retreatment System (PTRS) and WaveOne System (WS). Procedural errors, time of retreatment and apically extruded material were recorded for all the roots. The roots were radiographed after retreatment. The percentage of residual material was calculated using image analysis software. The data were analyzed by Kolmogorov-Smirnov and t tests, with a significance level set at 5%. No system completely removed the root filling material from the root canal. No significant differences were observed between the systems, in terms of residual filling material in any tested third (p &gt; 0.05). WS was faster in removing filling material than PTRS (p&lt; 0.05). Extrusion was observed in 4 cases in PTRS and in 5 cases in WS. No procedural errors were observed in either group. It can be concluded that although no differences were observed in the efficacy of PTRS and WS for removing root filling material, WS was faster than PTRS.
DOI: 10.6084/m9.figshare.7130942
title: CNVK paper - reverse crosslink human data

description: Reverse crosslinking experiment for https://www.ncbi.nlm.nih.gov/pubmed/29246928<br>Please contact us for additional information and clarification if you'd like to use this data (it was not used/mentioned in the original manuscript, as reversal of crosslinking involved boiling the RNA at 90C, which resulted in degradation as opposed to bona fide reversal). <br>This data is stored here for purposes of archiving.
DOI: 10.6084/m9.figshare.7130945.v1
title: Effect of different solutions on color stability of acrylic resin-based dentures

description: The aim of this study was to evaluate the effect of thermocycling and immersion in mouthwash or beverage solutions on the color stability of four different acrylic resin-based dentures (Onda Cryl, OC; QC20, QC; Classico, CL; and Lucitone, LU). The factors evaluated were type of acrylic resin, immersion time, and solution (mouthwash or beverage). A total of 224 denture samples were fabricated. For each type of resin, eight samples were immersed in mouthwashes (Plax-Colgate, PC; Listerine, LI; and Oral-B, OB), beverages (coffee, CP; cola, C; and wine, W), and artificial saliva (AS; control). The color change (DE) was evaluated before (baseline) and after thermocycling (T1), and after immersion in solution for 1 h (T2), 3 h (T3), 24 h (T4), 48 h (T5), and 96 h (T6). The CIE Lab system was used to determine the color changes. The thermocycling test was performed for 5000 cycles. Data were submitted to three-way repeated-measures analysis of variance and Tukey's test (p &lt; 0.05). When the samples were immersed in each mouthwash, all assessed factors, associated or not, significantly influenced the color change values, except there was no association between the mouthwash and acrylic resin. Similarly, when the samples were immersed in each beverage, all studied factors influenced the color change values. In general, regardless of the solution, LU exhibited the greatest DE values in the period from T1 to T5; and QC presented the greatest DE values at T6. Thus, thermocycling and immersion in the various solutions influenced the color stability of acrylic resins and QC showed the greatest color alteration.
DOI: 10.6084/m9.figshare.7130948.v1
title: Effectiveness of rotatory and reciprocating movements in root canal filling material removal

description: The purpose of this study was to compare the efficacy of reciprocating and rotary techniques for removing gutta-percha and sealer from root canals. Forty straight and oval single-rooted premolars were prepared up to size 30, filled with gutta-percha and sealer, and then randomly allocated to two experimental retreatment groups: ProTaper Retreatment System (PTRS) and WaveOne System (WS). Procedural errors, time of retreatment and apically extruded material were recorded for all the roots. The roots were radiographed after retreatment. The percentage of residual material was calculated using image analysis software. The data were analyzed by Kolmogorov-Smirnov and t tests, with a significance level set at 5%. No system completely removed the root filling material from the root canal. No significant differences were observed between the systems, in terms of residual filling material in any tested third (p &gt; 0.05). WS was faster in removing filling material than PTRS (p&lt; 0.05). Extrusion was observed in 4 cases in PTRS and in 5 cases in WS. No procedural errors were observed in either group. It can be concluded that although no differences were observed in the efficacy of PTRS and WS for removing root filling material, WS was faster than PTRS.
DOI: 10.7284/107692
title: Winch data collected during research cruise ZHNG09RR using a Markey DUTW-9-11 instrument system onboard the platform RV Roger Revelle

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7130942.v2
title: CNVK paper - reverse crosslink human data

description: Reverse crosslinking experiment for https://www.ncbi.nlm.nih.gov/pubmed/29246928<br>Please contact us for additional information and clarification if you'd like to use this data (it was not used/mentioned in the original manuscript, as reversal of crosslinking involved boiling the RNA at 90C, which resulted in degradation as opposed to bona fide reversal). <br>This data is stored here for purposes of archiving.
DOI: 10.7284/107696
title: GNSS (Global Navigation Satellite System) data collected during research cruise ZHNG10RR using a Furuno GP-90D instrument system onboard the platform RV Roger Revelle
DOI: 10.6084/m9.figshare.7130942.v1
title: CNVK paper - reverse crosslink human data

description: Reverse crosslinking experiment for https://www.ncbi.nlm.nih.gov/pubmed/29246928<br>Please contact us for additional information and clarification if you'd like to use this data (it was not used/mentioned in the original manuscript, as reversal of crosslinking involved boiling the RNA at 90C, which resulted in degradation as opposed to bona fide reversal). <br>This data is stored here for purposes of archiving.
DOI: 10.6084/m9.figshare.7130849
title: A 3D cat object model

description: test
DOI: 10.6084/m9.figshare.7130849.v1
title: A 3D cat object model

description: test
DOI: 10.6084/m9.figshare.7130774.v1
title: Male and Female Mice Uranium Tissue ICP/MS and Water Intake Data

description: Male and Female C57BL/6J Mice, Tissue Uranium ICP/MS and Water intake data for mice exposed to uranium for 60-days
DOI: 10.6084/m9.figshare.7130774.v3
title: Male and Female Mice Uranium Tissue ICP/MS and Water Intake Data. Following a 60-day Drinking Water Exposure to 5 and 50 ppm Uranium (uranyl acetate).

description: Male and Female C57BL/6J Mice, Tissue Uranium ICP/MS and Water intake data for mice exposed to uranium for 60-days (uranyl acetate).Bolt AM. et. al. Title of Manuscript: Minimal uranium accumulation in lymphoid tissues following an oral 60-day uranyl acetate exposure in male and female C57BL/6J mice. PLos One. 2018 PONE-D-18-22528R1<br> <br>
DOI: 10.6084/m9.figshare.7130774.v2
title: Male and Female Mice Uranium Tissue ICP/MS and Water Intake Data. Following a 60-day Drinking Water Exposure to 5 and 50 ppm Uranium (uranyl acetate).

description: Male and Female C57BL/6J Mice, Tissue Uranium ICP/MS and Water intake data for mice exposed to uranium for 60-days (uranyl acetate).Bolt AM. et. al. Title of Manuscript: Minimal uranium accumulation in lymphoid tissues following an oral 60-day uranyl acetate exposure in male and female C57BL/6J mice. PLos One. 2018 PONE-D-18-22528R1<br> <br>
DOI: 10.6084/m9.figshare.7130603.v2
title: SI kinematics data.xlsx

description: Body and wing kinematics
DOI: 10.6084/m9.figshare.7130603.v1
title: SI kinematics data.xlsx

description: Body and wing kinematics
DOI: 10.6084/m9.figshare.7130570
title: iot vulnerability assessment graph

description: The graph shows the statistics of the output of the vulnerability assessment of IoT devices at European Organization for Nuclear Research(CERN).
DOI: 10.6084/m9.figshare.7130402
title: Yurkowski et al. 2018 - Arctic Hotspots DDI shapefiles.zip

description: These filesets support data from the following paper published in <i>Diversity and Distributions</i>:<br><b>Abundance and species diversity hotspots of tracked marine predators across the North American Arctic</b><br><br>DOI: 10.1111/ddi.12860<br>These filesets are GIS shapefiles (WGS84 projection) which contain the Getis-Ord Gi* analysis outputs for abundance densities and hotspots by species group and abundance and species diversity densities and hotspots across species groups by season.<br>Species groups<br>"CP" - cetaceans and pinnipeds"SB" - seabirds"PB" - polar bears<br>Headings<br>"FID" - grid cell number<br>"Count_PTT" - number of unique individuals"Count_Spec" - number of unique species<br>"GiZScore" - Getis-Ord Z score"GiPValue" - Getis-Ord P-value"Gi_Bin" - statistically significant hotspots at a=0.90 (1), 0.95 (2) and 0.99 (3) levels. Statistically significant coldspots at a=0.90 (-1), 0.95 (-2) and 0.99 (-3) levels. A score of 0 is non-significant. <br><br>See the following link for more details on Getis-Ord Gi* output from ArcGIS: http://desktop.arcgis.com/en/arcmap/10.3/tools/spatial-statistics-toolbox/hot-spot-analysis.htm<br><br>
DOI: 10.25373/ctsnet.7129211
title: Robotic Right Upper Lobe Posterior Segmentectomy With ICG Guidance

description: This video demonstrates a robotic right upper lobe segmentectomy using indocyanine green (ICG) guidance. The patient was a 73-year-old woman who had a previous left lower lobectomy for squamous cell cancer and removal of a malignant station L8 lymph node. She presented with a new nodule in the posterior segment of her right upper lobe, which was thought to be a new primary cancer. Segmentectomy was therefore the procedure of choice in order to conserve as much pulmonary function as possible.ICG was used in order to aid and confirm decision making when a posterior ascending artery with an early bifurcation was encountered, helping to determine whether both of the branches provided vascularization to the posterior segment in question.<br>
DOI: 10.25373/ctsnet.7129211.v1
title: Robotic Right Upper Lobe Posterior Segmentectomy With ICG Guidance

description: This video demonstrates a robotic right upper lobe segmentectomy using indocyanine green (ICG) guidance. The patient was a 73-year-old woman who had a previous left lower lobectomy for squamous cell cancer and removal of a malignant station L8 lymph node. She presented with a new nodule in the posterior segment of her right upper lobe, which was thought to be a new primary cancer. Segmentectomy was therefore the procedure of choice in order to conserve as much pulmonary function as possible.ICG was used in order to aid and confirm decision making when a posterior ascending artery with an early bifurcation was encountered, helping to determine whether both of the branches provided vascularization to the posterior segment in question.<br>
DOI: 10.6084/m9.figshare.7128689
title: Leviathan Biomonitoring Data Archive DB Herbst.xlsx

description: Data matrix on several spreadsheet tabs that show stream sites monitored by name and date. One tab with metals chemsitry, another that converts metals chemistry to cumulative criterion units of toxicological response, and another tab that shows the density of macroinvertebrate taxa corresponding to the site and date where water quality data was collected.<br>
DOI: 10.6084/m9.figshare.7128566
title: S2_main_data.csv

description: Main dataset for the analysis in "Datasets for the analysis of venom from "Comparative analysis of snake venom supports prey-specific evolution of potency and that yield is driven by snake metabolic rate and habitat."
DOI: 10.6084/m9.figshare.7128689.v1
title: Leviathan Biomonitoring Data Archive DB Herbst.xlsx

description: Data matrix on several spreadsheet tabs that show stream sites monitored by name and date. One tab with metals chemsitry, another that converts metals chemistry to cumulative criterion units of toxicological response, and another tab that shows the density of macroinvertebrate taxa corresponding to the site and date where water quality data was collected.<br>
DOI: 10.6084/m9.figshare.7128527
title: An overview of glycopyrrolate/eFlow® CS in COPD

description: <b>Introduction</b>: COPD is highly prevalent in the US and globally, requiring new treatment strategies due to the high disease burden and increase in the aging population. Here, we profile the newly FDA-approved LONHALA MAGNAIR (glycopyrrolate [GLY]/eFlow® Closed System [CS]; 25 mcg twice daily), a nebulized long-acting muscarinic antagonist (LAMA) for the long-term maintenance treatment of COPD, including chronic bronchitis and/or emphysema. <b>Areas covered</b>: An overview of COPD and treatment landscape, focusing on GLY/eFlow CS, reviewing the published literature pertinent to the drug/device combination is reported. <b>Expert commentary</b>: GLY/eFlow CS consists of glycopyrrolate delivered via a novel electronic nebulizer and is the first nebulized LAMA to be approved by the FDA. GLY/eFlow CS has been studied in an extensive clinical development program, including phase II dose-ranging studies, two 12-week phase III studies demonstrating statistically significant and clinically important improvements in pulmonary function and patient-reported outcomes with a well-tolerated safety profile, and a 48-week phase III study highlighting the long-term safety of GLY/eFlow CS, along with long-term improvements in lung function and patient-reported outcomes. Additional studies are required to assess the impact of GLY/eFlow CS on COPD exacerbations, identify alternative uses of the eFlow CS nebulizer, and direct comparisons to other LAMAs.
DOI: 10.6084/m9.figshare.7128524
title: Supplementary Dataset S1 from Social bonds facilitate cooperative resource sharing in wild chimpanzees

description: All data used to fit the models
DOI: 10.6084/m9.figshare.7128524.v1
title: Supplementary Dataset S1 from Social bonds facilitate cooperative resource sharing in wild chimpanzees

description: All data used to fit the models
DOI: 10.5281/zenodo.4005582
title: GMC career progression data by UK medical school 1997-2007

description: The following data were extracted from the GMC register freely available online (https://data.gmc-uk.org/gmcdata/home/#/reports/Undergraduate%20training/Stats/report): · The proportion of graduates from 19 UK medical schools from 1997-2007 who entered the GP register, following research norms from McManus et al. (2000). · The proportion of graduates from 19 UK medical schools from 1997-2007 who entered the any specialist register · The proportion of graduates from 19 UK medical schools from 1997-2007 who remain in postgraduate training · The proportion of graduates from 19 medical schools from 1997-2007 who gained membership to the Royal College of Physicians. · The following data were extracted from a mix of University websites and the GMC register: · The size of graduating cohorts from 19 UK medical schools from 1997-2007 The following data were extrapolated from the above data: Number of graduates on the GP register · The national proportion of graduates who had entered the GP register · The proportion of missing data (1- (proportion in postgraduate training + proportion on any specialist register)
DOI: 10.5281/zenodo.4005581
title: GMC career progression data by UK medical school 1997-2007

description: The following data were extracted from the GMC register freely available online (https://data.gmc-uk.org/gmcdata/home/#/reports/Undergraduate%20training/Stats/report): · The proportion of graduates from 19 UK medical schools from 1997-2007 who entered the GP register, following research norms from McManus et al. (2000). · The proportion of graduates from 19 UK medical schools from 1997-2007 who entered the any specialist register · The proportion of graduates from 19 UK medical schools from 1997-2007 who remain in postgraduate training · The proportion of graduates from 19 medical schools from 1997-2007 who gained membership to the Royal College of Physicians. · The following data were extracted from a mix of University websites and the GMC register: · The size of graduating cohorts from 19 UK medical schools from 1997-2007 The following data were extrapolated from the above data: Number of graduates on the GP register · The national proportion of graduates who had entered the GP register · The proportion of missing data (1- (proportion in postgraduate training + proportion on any specialist register)
DOI: 10.6084/m9.figshare.7128479
title: Data from Hunter selection for larger and older male bobcats affects annual harvest demography

description: Data for statistical analyses
DOI: 10.6084/m9.figshare.7128458
title: The <i>Francisella novicida</i> Cas12a is sensitive to the structure downstream of the terminal repeat in CRISPR arrays

description: The Class 2 Type V-A CRISPR effector protein Cas12a/Cpf1 has gained widespread attention in part because of the ease in achieving multiplexed genome editing, gene regulation, and DNA detection. Multiplexing derives from the ability of Cas12a alone to generate multiple guide RNAs from a transcribed CRISPR array encoding alternating conserved repeats and targeting spacers. While array design has focused on how to optimize guide-RNA sequences, little attention has been paid to sequences outside of the CRISPR array. Here, we show that a structured hairpin located immediately downstream of the 3ʹ repeat interferes with utilization of the adjacent encoded guide RNA by <i>Francisella novicida</i> (Fn)Cas12a. We first observed that a synthetic Rho-independent terminator immediately downstream of an array impaired DNA cleavage based on plasmid clearance in <i>E. coli</i> and DNA cleavage in a cell-free transcription-translation (TXTL) system. TXTL-based cleavage assays further revealed that inhibition was associated with incomplete processing of the transcribed CRISPR array and could be attributed to the stable hairpin formed by the terminator. We also found that the inhibitory effect partially extended to upstream spacers in a multi-spacer array. Finally, we found that removing the terminal repeat from the array increased the inhibitory effect, while replacing this repeat with an unprocessable terminal repeat from a native FnCas12a array restored cleavage activity directed by the adjacent encoded guide RNA. Our study thus revealed that sequences surrounding a CRISPR array can interfere with the function of a CRISPR nuclease, with implications for the design and evolution of CRISPR arrays.
DOI: 10.6084/m9.figshare.7128458.v2
title: The <i>Francisella novicida</i> Cas12a is sensitive to the structure downstream of the terminal repeat in CRISPR arrays

description: The Class 2 Type V-A CRISPR effector protein Cas12a/Cpf1 has gained widespread attention in part because of the ease in achieving multiplexed genome editing, gene regulation, and DNA detection. Multiplexing derives from the ability of Cas12a alone to generate multiple guide RNAs from a transcribed CRISPR array encoding alternating conserved repeats and targeting spacers. While array design has focused on how to optimize guide-RNA sequences, little attention has been paid to sequences outside of the CRISPR array. Here, we show that a structured hairpin located immediately downstream of the 3ʹ repeat interferes with utilization of the adjacent encoded guide RNA by <i>Francisella novicida</i> (Fn)Cas12a. We first observed that a synthetic Rho-independent terminator immediately downstream of an array impaired DNA cleavage based on plasmid clearance in <i>E. coli</i> and DNA cleavage in a cell-free transcription-translation (TXTL) system. TXTL-based cleavage assays further revealed that inhibition was associated with incomplete processing of the transcribed CRISPR array and could be attributed to the stable hairpin formed by the terminator. We also found that the inhibitory effect partially extended to upstream spacers in a multi-spacer array. Finally, we found that removing the terminal repeat from the array increased the inhibitory effect, while replacing this repeat with an unprocessable terminal repeat from a native FnCas12a array restored cleavage activity directed by the adjacent encoded guide RNA. Our study thus revealed that sequences surrounding a CRISPR array can interfere with the function of a CRISPR nuclease, with implications for the design and evolution of CRISPR arrays.