cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.11966259.v1
title: Assessment of ventilatory function in patients with spinocerebellar ataxia type 2

description: Abstract Subclinical ventilatory dysfunction is observed in individuals with spinocerebellar ataxias (SCA). No studies have correlated ventilatory dysfunction to clinical and functional decline in SCA2. Objective: To evaluate the relationship between the values of peak expiratory flow (PEF), maximum inspiratory pressure (MIP), and presence of respiratory complaints with age, disease duration, age at onset of symptoms, balance scores, independence in basic (ADL) and instrumental (IADL) Activities of Daily Living (ADLs), and severity of ataxia (SARA) in individuals with SCA2. Methods: Cross-sectional study evaluating age, disease duration, age at onset of symptoms, scores in the Berg Balance Scale and in the SARA, Functional Independence Measure and Lawton’s scale, values of PEF and MIP, and the presence of respiratory complaints. Results: The study included 36 individuals with SCA2, with a mean age of 42.5±2.4 years, disease duration of 7.6±8.2 years, age 33.7±11.5 years at onset of symptoms, and 9.9±10.3 points in the SARA scale. The lowest PEF values correlated with the longer disease duration (p=0.021). The lowest values of PEF and MIP correlated with greater balance impairment (p=0.019 and p=0.045, respectively), increased degree of dependence in the ADL (p=0.006 and p=0.050, respectively) and IADL (p=0.003 and p=0.001, respectively) scales, and highest severity of ataxia (p=0.00 and p=0.017, respectively). Respiratory complaints were observed in 12 (33.3%) individuals and were not related to age, disease duration, age at onset of symptoms, balance, independence, ataxia severity, or PEF and MIP values. Conclusion: Ventilatory dysfunction, even when asymptomatic, is related to balance impairment, independence, and ataxia severity in individuals with SCA2.
DOI: 10.6084/m9.figshare.14268634.v1
title: Asymptomatic Huge Cardiac Hydatid Cyst Located in the Interventricular Septum

description: Abstract The cardiac involvement of hydatid cyst, which is rarely seen, with the location of asymptomatic huge cyst in the interventricular septum (IVS) is an extraordinary condition. We report an isolated cardiac hydatid cyst located in the IVS in an 18-year-old man diagnosed incidentally by transthoracic echocardiography. Cardiac magnetic resonance imaging confirmed a mass lesion of 47×74 mm in diameter located at the base of IVS. The cystic content and its germinative membrane were resected and the cavity was applicated under cardiopulmonary bypass. Postoperative course was uneventful and the patient was discharged on the 6th postoperative day, with oral albendazole therapy.
DOI: 10.6084/m9.figshare.14268636
title: Diagnostic prediction model for levodopa-induced dyskinesia in Parkinson’s disease

description: Abstract Background: There are currently no methods to predict the development of levodopa-induced dyskinesia (LID), a frequent complication of Parkinson's disease (PD) treatment. Clinical predictors and single nucleotide polymorphisms (SNP) have been associated to LID in PD. Objective: To investigate the association of clinical and genetic variables with LID and to develop a diagnostic prediction model for LID in PD. Methods: We studied 430 PD patients using levodopa. The presence of LID was defined as an MDS-UPDRS Part IV score ≥1 on item 4.1. We tested the association between specific clinical variables and seven SNPs and the development of LID, using logistic regression models. Results: Regarding clinical variables, age of PD onset, disease duration, initial motor symptom and use of dopaminergic agonists were associated to LID. Only CC genotype of ADORA2A rs2298383 SNP was associated to LID after adjustment. We developed two diagnostic prediction models with reasonable accuracy, but we suggest that the clinical prediction model be used. This prediction model has an area under the curve of 0.817 (95% confidence interval [95%CI] 0.77‒0.85) and no significant lack of fit (Hosmer-Lemeshow goodness-of-fit test p=0.61). Conclusion: Predicted probability of LID can be estimated with reasonable accuracy using a diagnostic clinical prediction model which combines age of PD onset, disease duration, initial motor symptom and use of dopaminergic agonists.
DOI: 10.6084/m9.figshare.14268636.v1
title: Diagnostic prediction model for levodopa-induced dyskinesia in Parkinson’s disease

description: Abstract Background: There are currently no methods to predict the development of levodopa-induced dyskinesia (LID), a frequent complication of Parkinson's disease (PD) treatment. Clinical predictors and single nucleotide polymorphisms (SNP) have been associated to LID in PD. Objective: To investigate the association of clinical and genetic variables with LID and to develop a diagnostic prediction model for LID in PD. Methods: We studied 430 PD patients using levodopa. The presence of LID was defined as an MDS-UPDRS Part IV score ≥1 on item 4.1. We tested the association between specific clinical variables and seven SNPs and the development of LID, using logistic regression models. Results: Regarding clinical variables, age of PD onset, disease duration, initial motor symptom and use of dopaminergic agonists were associated to LID. Only CC genotype of ADORA2A rs2298383 SNP was associated to LID after adjustment. We developed two diagnostic prediction models with reasonable accuracy, but we suggest that the clinical prediction model be used. This prediction model has an area under the curve of 0.817 (95% confidence interval [95%CI] 0.77‒0.85) and no significant lack of fit (Hosmer-Lemeshow goodness-of-fit test p=0.61). Conclusion: Predicted probability of LID can be estimated with reasonable accuracy using a diagnostic clinical prediction model which combines age of PD onset, disease duration, initial motor symptom and use of dopaminergic agonists.
DOI: 10.6084/m9.figshare.14268638
title: Silverleaf whitefly-resistant common beans: an investigation of antibiosis and/or antixenosis

description: ABSTRACT The silverleaf whitefly Bemisia tabaci biotype B is one of the most important sucking pests of common bean, which causes severe damages and requires frequently synthetic insecticides spraying to protect crop productivity. The use of common bean cultivars resistant to whitefly attack is an important strategy within an integrated pest management (IPM) program. The biological development of B. tabaci confined to 17 bean genotypes was evaluated in greenhouse trials to verify the occurrence of antibiosis. Whitefly adults were released on plants of these genotypes to oviposit, afterward the incubation period of eggs, nymphal period, complete development period (egg–adult), and viability of the silverleaf whitefly nymphs were recorded. As main results, genotype CHIP 300 prolonged the developmental period from egg to adult (~10 days) and BRS Estilo, Arcelina 4, IPR Garça, Tybatã, CHIP 300, IPR Eldorado, H96A102-1-1-1-52, SCS-202-Guará and CHIB 06 caused nymphal mortality, suggesting high levels of antibiosis and/or antixenosis. These genotypes may be helpful in common bean breeding programs aimed at developing commercial cultivars resistant to B. tabaci biotype B.
DOI: 10.6084/m9.figshare.14268638.v1
title: Silverleaf whitefly-resistant common beans: an investigation of antibiosis and/or antixenosis

description: ABSTRACT The silverleaf whitefly Bemisia tabaci biotype B is one of the most important sucking pests of common bean, which causes severe damages and requires frequently synthetic insecticides spraying to protect crop productivity. The use of common bean cultivars resistant to whitefly attack is an important strategy within an integrated pest management (IPM) program. The biological development of B. tabaci confined to 17 bean genotypes was evaluated in greenhouse trials to verify the occurrence of antibiosis. Whitefly adults were released on plants of these genotypes to oviposit, afterward the incubation period of eggs, nymphal period, complete development period (egg–adult), and viability of the silverleaf whitefly nymphs were recorded. As main results, genotype CHIP 300 prolonged the developmental period from egg to adult (~10 days) and BRS Estilo, Arcelina 4, IPR Garça, Tybatã, CHIP 300, IPR Eldorado, H96A102-1-1-1-52, SCS-202-Guará and CHIB 06 caused nymphal mortality, suggesting high levels of antibiosis and/or antixenosis. These genotypes may be helpful in common bean breeding programs aimed at developing commercial cultivars resistant to B. tabaci biotype B.
DOI: 10.6084/m9.figshare.14268640
title: Algoritmo de Seguimento do Ponto de Máxima Potência para Sistemas Fotovoltaicos considerando Minimização de Erro e Derivada da Potência

description: ABSTRACT In this work, a new maximum power point tracking algorithm (MPPT) for photovoltaic systems is proposed. The considered system is composed by a photovoltaic panel charging a battery using a buck-type dc-dc converter. Computational simulations are carried out to compare the performance of the MPPT algorithms, analyzing the output voltage and output power behavior at the photovoltaic panel. Three evaluation scenarios were considered: with constant irradiance and temperature, randomly chosen and using real data. The results of the simulations show that the proposed algorithm provides better performance for the photovoltaic system than the main MPPT algorithms in the literature.
DOI: 10.6084/m9.figshare.14268640.v1
title: Algoritmo de Seguimento do Ponto de Máxima Potência para Sistemas Fotovoltaicos considerando Minimização de Erro e Derivada da Potência

description: ABSTRACT In this work, a new maximum power point tracking algorithm (MPPT) for photovoltaic systems is proposed. The considered system is composed by a photovoltaic panel charging a battery using a buck-type dc-dc converter. Computational simulations are carried out to compare the performance of the MPPT algorithms, analyzing the output voltage and output power behavior at the photovoltaic panel. Three evaluation scenarios were considered: with constant irradiance and temperature, randomly chosen and using real data. The results of the simulations show that the proposed algorithm provides better performance for the photovoltaic system than the main MPPT algorithms in the literature.
DOI: 10.6084/m9.figshare.14268642
title: An Expedient Synthesis of Tacrine-Squaric Hybrids as Potent, Selective and Dual-Binding Cholinesterase Inhibitors

description: The restoration of acetylcholine levels in the brain by inhibition of cholinesterases is currently the most successful therapeutic strategy to treat neurodegenerative disorders. In this context, tacrine has been largely investigated as a starting scaffold for the development of promising new anticholinesterases compounds for the treatment of neurodegenerative illnesses, including Alzheimer’s disease. Here we present a series of compounds containing the tacrine nucleus connected with squaric moiety by a diaminoalkylene chain. The compounds were obtained through a simple and short synthetic route and showed high inhibitory activity against acetylcholinesterase (AChE) within nanomolar IC50 (half maximal inhibitory concentration). The molecular modelling study showed that these compounds act as dual-binding inhibitors of AChE, interacting with both catalytic active site (CAS) and peripheral anionic site (PAS) of the enzyme’s binding cavity. The investigated compounds also demonstrated outstanding selectivity for AChE than in butyrylcholinesterase (BuChE). These results evince these compounds as promising agents for the treatment of neurodegenerative disorders and a fuller synthetic scope jointly with complementary biological evaluations are currently under investigation in our laboratory.
DOI: 10.6084/m9.figshare.14268642.v1
title: An Expedient Synthesis of Tacrine-Squaric Hybrids as Potent, Selective and Dual-Binding Cholinesterase Inhibitors

description: The restoration of acetylcholine levels in the brain by inhibition of cholinesterases is currently the most successful therapeutic strategy to treat neurodegenerative disorders. In this context, tacrine has been largely investigated as a starting scaffold for the development of promising new anticholinesterases compounds for the treatment of neurodegenerative illnesses, including Alzheimer’s disease. Here we present a series of compounds containing the tacrine nucleus connected with squaric moiety by a diaminoalkylene chain. The compounds were obtained through a simple and short synthetic route and showed high inhibitory activity against acetylcholinesterase (AChE) within nanomolar IC50 (half maximal inhibitory concentration). The molecular modelling study showed that these compounds act as dual-binding inhibitors of AChE, interacting with both catalytic active site (CAS) and peripheral anionic site (PAS) of the enzyme’s binding cavity. The investigated compounds also demonstrated outstanding selectivity for AChE than in butyrylcholinesterase (BuChE). These results evince these compounds as promising agents for the treatment of neurodegenerative disorders and a fuller synthetic scope jointly with complementary biological evaluations are currently under investigation in our laboratory.
DOI: 10.6084/m9.figshare.14268649
title: History of fluoridation policies as a strategy by the Brazilian Legislative Branch to fight dental caries, 1963 to 2019

description: Abstract: The aim of this study was to analyze legislative proceedings on fluoridation policies in Brazil from 1963 to 2019. The theoretical reference was Pierre Bourdieu. A document search was performed on legislative proceedings that address the theme of fluoridation in Brazil as a public health measure and the discussions in the National Congress. The sources for the article were the official websites of the Chamber of Deputies (lower house) and the Senate to consult the legislative acts related to fluoridation in Brazil. The study showed that from 1963 to 2001 and in 2017 there was a dispute between fluoridation methods for the water supply, mineral water, and table salt fluoridation. However, there was a crosscutting understanding of the importance and benefits of systemic fluoride use. From 2003 to 2013, the bills challenged the use of systemic fluoride, proposing its use only in topical applications. In the 1960s, 1970, and 2017, the legislative bills showed a closer approach to the scientific field and were submitted by opposition members of Congress. Unlike the issue of water fluoridation, of the 6 legislative bills in favor of salt fluoridation, only one was drafted by a health professional da health, and only two by legislators from the Southeast region. There were more bills by legislators from the Central and Northeast. Those with training in health exhibited positions in defense of some method of systemic fluoridation. The analysis allowed interpreting the historical process of developing the response to the caries problem and the different strategies employed in this process.
DOI: 10.6084/m9.figshare.14268649.v1
title: History of fluoridation policies as a strategy by the Brazilian Legislative Branch to fight dental caries, 1963 to 2019

description: Abstract: The aim of this study was to analyze legislative proceedings on fluoridation policies in Brazil from 1963 to 2019. The theoretical reference was Pierre Bourdieu. A document search was performed on legislative proceedings that address the theme of fluoridation in Brazil as a public health measure and the discussions in the National Congress. The sources for the article were the official websites of the Chamber of Deputies (lower house) and the Senate to consult the legislative acts related to fluoridation in Brazil. The study showed that from 1963 to 2001 and in 2017 there was a dispute between fluoridation methods for the water supply, mineral water, and table salt fluoridation. However, there was a crosscutting understanding of the importance and benefits of systemic fluoride use. From 2003 to 2013, the bills challenged the use of systemic fluoride, proposing its use only in topical applications. In the 1960s, 1970, and 2017, the legislative bills showed a closer approach to the scientific field and were submitted by opposition members of Congress. Unlike the issue of water fluoridation, of the 6 legislative bills in favor of salt fluoridation, only one was drafted by a health professional da health, and only two by legislators from the Southeast region. There were more bills by legislators from the Central and Northeast. Those with training in health exhibited positions in defense of some method of systemic fluoridation. The analysis allowed interpreting the historical process of developing the response to the caries problem and the different strategies employed in this process.
DOI: 10.6084/m9.figshare.14268646
title: Financial abuse: circumstances of occurrences against older adults

description: Abstract Objective: To analyze the occurrences of financial abuse against older adults. Methods: a descriptive and retrospective cross-sectional study with a qualitative and quantitative approach was conducted through the analysis of 209 Police Reports (PR) of financial abuse against older adults, dated between October 2016 and March 2017. Data analysis was performed by content analysis in the thematic modality. Results: The profile of the victims was characterized as follows: male (50.72%), aged from 60 to 69 years old (56.6%) and living with a partner (48.33%). Financial abuse against older adults is mainly committed by strangers, in 85.6% of cases, and in 6.7% of cases by family members. The sociodemographic characteristics of most offenders were unknown. Three cores of meaning relating to the types of financial abuse were identified: appropriation and damage; exposure to fraud/extortion and theft/robbery. Conclusion: There is a need for actions aimed at preventing and protecting against the financial abuse of older adults, in order to avoid suffering and emotional, physical and social harm. In addition, further studies are needed to more effectively highlight the association of alterations during the aging process and financial violence.
DOI: 10.6084/m9.figshare.14268646.v1
title: Financial abuse: circumstances of occurrences against older adults

description: Abstract Objective: To analyze the occurrences of financial abuse against older adults. Methods: a descriptive and retrospective cross-sectional study with a qualitative and quantitative approach was conducted through the analysis of 209 Police Reports (PR) of financial abuse against older adults, dated between October 2016 and March 2017. Data analysis was performed by content analysis in the thematic modality. Results: The profile of the victims was characterized as follows: male (50.72%), aged from 60 to 69 years old (56.6%) and living with a partner (48.33%). Financial abuse against older adults is mainly committed by strangers, in 85.6% of cases, and in 6.7% of cases by family members. The sociodemographic characteristics of most offenders were unknown. Three cores of meaning relating to the types of financial abuse were identified: appropriation and damage; exposure to fraud/extortion and theft/robbery. Conclusion: There is a need for actions aimed at preventing and protecting against the financial abuse of older adults, in order to avoid suffering and emotional, physical and social harm. In addition, further studies are needed to more effectively highlight the association of alterations during the aging process and financial violence.
DOI: 10.6084/m9.figshare.14268651.v1
title: Chitosan and Agaricus brasiliensis Polysaccharides Films: A Preliminary Study

description: The known biotechnological properties of chitosan and the recent biological activities attributed to polysaccharides from Agaricus brasiliensis have been of interest to obtain films constituted by these two polymers. The glucans obtained from the mushroom inhibited about 96.5% of the ferrous ion, besides not promoting a significant increase of lactate dehydrogenase enzyme (LDH), which indicates that the polysaccharide is able to inhibit the production of radical species and also presents low cytotoxicity to the biological systems. The results of spectroscopy analyses in the infrared region (FTIR) and X-ray diffraction suggest an existing electrostatic interaction between the substances. A reduction in the films’ swelling capacity was observed with an increase in the polysaccharide content in the composition. In addition, scanning electron microscopy (SEM) revealed greater surface density of the films. In convening the biological properties of the substances, it is expected that this study raises interest in evaluating the films and their capacity for healing wounds and burns.
DOI: 10.6084/m9.figshare.14268651
title: Chitosan and Agaricus brasiliensis Polysaccharides Films: A Preliminary Study

description: The known biotechnological properties of chitosan and the recent biological activities attributed to polysaccharides from Agaricus brasiliensis have been of interest to obtain films constituted by these two polymers. The glucans obtained from the mushroom inhibited about 96.5% of the ferrous ion, besides not promoting a significant increase of lactate dehydrogenase enzyme (LDH), which indicates that the polysaccharide is able to inhibit the production of radical species and also presents low cytotoxicity to the biological systems. The results of spectroscopy analyses in the infrared region (FTIR) and X-ray diffraction suggest an existing electrostatic interaction between the substances. A reduction in the films’ swelling capacity was observed with an increase in the polysaccharide content in the composition. In addition, scanning electron microscopy (SEM) revealed greater surface density of the films. In convening the biological properties of the substances, it is expected that this study raises interest in evaluating the films and their capacity for healing wounds and burns.
DOI: 10.6084/m9.figshare.14268655
title: A nationwide study on prevalence and factors associated with dynapenia in older adults: ELSI-Brazil

description: This study aimed to assess the prevalence and factors associated with dynapenia in a nationally representative sample of Brazilians aged 50 years and older. A cross-sectional study was performed with baseline data from the Brazilian Longitudinal Study of Aging (ELSI-Brazil). Dynapenia was defined as low muscle strength (&lt; 27kg for men and &lt; 16kg for women). Explanatory variables were sociodemographic characteristics, health conditions, health behaviors and physical performance. Analyses were based on multivariate logistic regression and population attributable fractions. Among the 8,396 participants, the prevalence of dynapenia was 17.2% (16.6% among men and 17.7% among women); for those aged 65 years and older, the prevalence was 28.2% (29.1% and 27.5% among men and women, respectively). Dynapenia was positively associated with age, low gait speed, limitations in performing two or more basic daily activities, falls and self-reported chronic diseases; and negatively associated with education level, physical activity and body mass index (overweight/obese, OR = 0.26). Prevalence of dynapenia is high in Brazilian older adults. Educational skills and physical activity improvement present greater potential to reduce dynapenia in this population.