cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.25442/hku.27999536.v1
title: Supporting data for "Current Treatment for Lupus Nephritis Direct Cellular Effects that Impact on Kidney Inflammation and Fibrosis"

description: This data contain the result from in vivo study including the change in body weight, ACR, BUN, serum creatinine, serum anti-dsDNA antibody levels, and havcr1 and lcn2 mRNA expression in renal cortex.Immunosuppressive therapy is a part of the standard-of-care of the lupus nephritis, and some of the immunosuppressants were recently revealed their renal protective effects in renal resident cells apart from their immunosuppressive effects. The purpose of this study is to investigate the effects and molecular mechanism of these renal protective effect in renal resident cells. Our <i>in vivo</i><i> </i>study investigated the effect of immunosuppressive monotherapy on the pro-inflammatory and profibrotic mediators in New Zealand Black and White F1 (NZB/W F1) mice, a well-established lupus-prone murine model. The uploaded results contain the assessment of serological and clinical parameters reflecting the renal function of the experiment mice, including the change in body weight, change in ACR, BUN level, serum creatinine level, serum anti-dsDNA antibody level, and <i>havcr1</i> and <i>lcn2</i> mRNA expression in renal cortex.
DOI: 10.25442/hku.27990539
title: <i>Supporting data for “</i>Preventing proximal caries in neighboring tooth with glass ionomer cement restoration and silver diamine fluoride pretreatment<i> ”</i>

description: To enhance the antimicrobial effect of GIC restoration, this study used silver diamine fluoride (SDF) solution as dentin pretreatment prior to GIC restoration. The first laboratory study assessed the fluoride and silver ion release of GIC restorations, including CGIC and RMGIC restorations, with 38% SDF solution dentin pretreatment. The results showed that 38% SDF dentin pretreatment sustainably increased the fluoride and silver release of GIC restorations for up to 2 years. Hence, the following laboratory studies used an in vitro model to investigate the enamel caries preventive effects of 38% SDF pretreatment on neighboring tooth proximal to GIC restorations. The results indicated that SDF pretreatment enhanced the preventive effect of GIC on proximal enamel surface on neighboring tooth through inhibiting cariogenic biofilm, reducing enamel demineralization and promoting enamel remineralization. After that the preventive effects of 38% SDF pretreatment on GIC restorations against root caries on neighboring tooth was investigated. The results showed that SDF pretreatment enhanced the preventive effect of GIC on the proximal dentin surface of neighboring tooth by inhibiting cariogenic biofilm, dentine demineralization and collagen degradation. The fourth laboratory study was performed to develop an antimicrobial silver zeolite glass ionomer cement (SZ-GIC) and determine its biocompatibility, physical, adhesive and antibacterial properties. The results showed that SZ-GIC exhibited enhanced physical, adhesive and antibacterial properties compared to GIC.
DOI: 10.25442/hku.27990539.v1
title: <i>Supporting data for “</i>Preventing proximal caries in neighboring tooth with glass ionomer cement restoration and silver diamine fluoride pretreatment<i> ”</i>

description: To enhance the antimicrobial effect of GIC restoration, this study used silver diamine fluoride (SDF) solution as dentin pretreatment prior to GIC restoration. The first laboratory study assessed the fluoride and silver ion release of GIC restorations, including CGIC and RMGIC restorations, with 38% SDF solution dentin pretreatment. The results showed that 38% SDF dentin pretreatment sustainably increased the fluoride and silver release of GIC restorations for up to 2 years. Hence, the following laboratory studies used an in vitro model to investigate the enamel caries preventive effects of 38% SDF pretreatment on neighboring tooth proximal to GIC restorations. The results indicated that SDF pretreatment enhanced the preventive effect of GIC on proximal enamel surface on neighboring tooth through inhibiting cariogenic biofilm, reducing enamel demineralization and promoting enamel remineralization. After that the preventive effects of 38% SDF pretreatment on GIC restorations against root caries on neighboring tooth was investigated. The results showed that SDF pretreatment enhanced the preventive effect of GIC on the proximal dentin surface of neighboring tooth by inhibiting cariogenic biofilm, dentine demineralization and collagen degradation. The fourth laboratory study was performed to develop an antimicrobial silver zeolite glass ionomer cement (SZ-GIC) and determine its biocompatibility, physical, adhesive and antibacterial properties. The results showed that SZ-GIC exhibited enhanced physical, adhesive and antibacterial properties compared to GIC.
DOI: 10.25442/hku.27999014
title: Supporting data for “Heterogenous Fenton Catalysis in Filter Media for Effective Removal of Pharmaceuticals and Personal Care Product in Water”

description: This dataset supports research on the effective removal of PPCPs from water, encompassing comprehensive characterization of catalytic filter through cost analysis, BET, E coli test, EPR, OPI, SEM, and TGA techniques to elucidate the physicochemical properties, catalytic mechanisms, behaviors, and environmental impact for sustainable water treatment applications.
DOI: 10.25442/hku.27999014.v1
title: Supporting data for “Heterogenous Fenton Catalysis in Filter Media for Effective Removal of Pharmaceuticals and Personal Care Product in Water”

description: This dataset supports research on the effective removal of PPCPs from water, encompassing comprehensive characterization of catalytic filter through cost analysis, BET, E coli test, EPR, OPI, SEM, and TGA techniques to elucidate the physicochemical properties, catalytic mechanisms, behaviors, and environmental impact for sustainable water treatment applications.
DOI: 10.25442/hku.27965877
title: Supporting data for "Laser-Induced Synthesis and Augmentation of Non-Precious Metal Electrocatalysts for Sustainable Energy Catalysis"

description: This dataset is related to the thesis titled "Laser-Induced Synthesis and Augmentation of Non-Precious Metal Electrocatalysts for Sustainable Energy Catalysis". It encompasses experimental data, including physical characterizations, assessments of electrochemical catalytic properties, and examinations of mechanisms. This dataset mainly focuses on transition metal-based electrocatalysts and their derivatives generated using pulsed laser irradiation. The study investigates materials like metal complexes, metal-organic frameworks (MOFs), and high entropy alloy (oxy)hydroxides, aiming to enhance their catalytic activity for electrochemical reactions such as hydrogen evolution reaction (HER), oxygen evolution reaction (OER), and oxygen reduction reaction (ORR). Techniques such as scanning electron microscopy (SEM), transmission electron microscopy (TEM), and X-ray diffraction spectroscopy (XRD) were utilized to analyze the samples' structures, compositions, and morphologies. Subsequently, electrochemical potentiostats were employed to evaluate the catalytic performance of these samples. Lastly, mechanistic studies were undertaken to elucidate the impact of pulsed laser treatment and its contribution to the enhancement of catalytic performance.
DOI: 10.25442/hku.27965877.v1
title: Supporting data for "Laser-Induced Synthesis and Augmentation of Non-Precious Metal Electrocatalysts for Sustainable Energy Catalysis"

description: This dataset is related to the thesis titled "Laser-Induced Synthesis and Augmentation of Non-Precious Metal Electrocatalysts for Sustainable Energy Catalysis". It encompasses experimental data, including physical characterizations, assessments of electrochemical catalytic properties, and examinations of mechanisms. This dataset mainly focuses on transition metal-based electrocatalysts and their derivatives generated using pulsed laser irradiation. The study investigates materials like metal complexes, metal-organic frameworks (MOFs), and high entropy alloy (oxy)hydroxides, aiming to enhance their catalytic activity for electrochemical reactions such as hydrogen evolution reaction (HER), oxygen evolution reaction (OER), and oxygen reduction reaction (ORR). Techniques such as scanning electron microscopy (SEM), transmission electron microscopy (TEM), and X-ray diffraction spectroscopy (XRD) were utilized to analyze the samples' structures, compositions, and morphologies. Subsequently, electrochemical potentiostats were employed to evaluate the catalytic performance of these samples. Lastly, mechanistic studies were undertaken to elucidate the impact of pulsed laser treatment and its contribution to the enhancement of catalytic performance.
DOI: 10.25442/hku.27959133
title: Supporting data for "Desymmetric Cyanosilylation of Acyclic 1,3-Diketones & Utilization of Transition Metal-1,3-Dicarbonyl Complexes for the Synthesis of Ni(II), Cu(II)-Dibenzotetraaza[14]annulene(DBTAA) Linked Covalent Organic Frameworks (COFs) and Polymers"

description: The diastereo- and enantioselective creation of vicinal stereocenters from easily accessible starting materials poses a challenge, and the development of acyclic quaternary stereocenters through intermolecular functionalization of linear diketones remains relatively unexplored. The first topic introduces a desymmetric cyanosilylation reaction of acyclic 1,3-diketones. In this study, a bifunctional catalyst derived from dibutyl magnesium and a tetradentate ligand based on pipecolic acid catalyzes an asymmetric cyanosilylation of 1,3-diketones, leading to the formation of vicinal and acyclic tetrasubstituted carbons. This method allows for synthesizing silyl ethers of cyanohydrins with precise stereochemistry and diverse substituents. Additionally, successful demonstrations have been made of converting these compounds into more complex molecules such as heterocycles, triols, and fused rings.The lack of robust linkages and functionalization methods are two obstacles to the development of COFs. Incorporating TM-DBTAA macrocycle into framework materials shows great promise for various applications such as conductive materials, catalysis, and sensors. However, limited methods for synthesizing stable TM-DBTAA-linked COFs hindered the construction of versatile COF structures with functionalized TM-DBTAA linkage. The second topic presents a novel approach to synthesizing TM-DBTAA-linked COFs and polymers, significantly expanding the structural and functional versatility of this valuable material category.<br>
DOI: 10.25442/hku.27959133.v1
title: Supporting data for "Desymmetric Cyanosilylation of Acyclic 1,3-Diketones & Utilization of Transition Metal-1,3-Dicarbonyl Complexes for the Synthesis of Ni(II), Cu(II)-Dibenzotetraaza[14]annulene(DBTAA) Linked Covalent Organic Frameworks (COFs) and Polymers"

description: The diastereo- and enantioselective creation of vicinal stereocenters from easily accessible starting materials poses a challenge, and the development of acyclic quaternary stereocenters through intermolecular functionalization of linear diketones remains relatively unexplored. The first topic introduces a desymmetric cyanosilylation reaction of acyclic 1,3-diketones. In this study, a bifunctional catalyst derived from dibutyl magnesium and a tetradentate ligand based on pipecolic acid catalyzes an asymmetric cyanosilylation of 1,3-diketones, leading to the formation of vicinal and acyclic tetrasubstituted carbons. This method allows for synthesizing silyl ethers of cyanohydrins with precise stereochemistry and diverse substituents. Additionally, successful demonstrations have been made of converting these compounds into more complex molecules such as heterocycles, triols, and fused rings.The lack of robust linkages and functionalization methods are two obstacles to the development of COFs. Incorporating TM-DBTAA macrocycle into framework materials shows great promise for various applications such as conductive materials, catalysis, and sensors. However, limited methods for synthesizing stable TM-DBTAA-linked COFs hindered the construction of versatile COF structures with functionalized TM-DBTAA linkage. The second topic presents a novel approach to synthesizing TM-DBTAA-linked COFs and polymers, significantly expanding the structural and functional versatility of this valuable material category.<br>
DOI: 10.25442/hku.27991631
title: Supporting data for "Role of tumour associated neutrophils in metabolic dysfunction-associated hepatocellular carcinoma development"

description: This dataset accompanies the thesis submitted for PhD candidature by Teo Jia Ming Nickolas. The data is also available under the GEO accession GSE240840.The thesis regards the role of tumour associated neutrophils in metabolic dysfunction-associated hepatocellular carcinoma development. Neutrophils accumulate in solid tumours and their abundance are often associated with poor prognosis. Emerging evidence reveals that tumour-associated neutrophils (TANs) are highly heterogeneous, comprising of both pro- and anti-tumour subsets. Hence, TANs can differentially influence tumour progression and therapy efficacy depending on their diversity within the tumour microenvironment (TME). However, the factors driving TAN diversity, the functions of specific TAN subsets, and the spread of their heterogeneity in different cancer contexts remain largely unknown. Metabolic dysfunction-associated steatohepatitis (MASH) is the fastest growing cause of hepatocellular carcinoma (HCC). Crucially, despite abundant T cell infiltration, this fatty liver etiology is notoriously resistant towards immune checkpoint blockade (ICB) therapy. This treatment deficit likely arises from immunosuppressive factors in the TME. As neutrophils are one of the most prominent immune populations in the HCC TME, their diversity likely play key roles in MASH-HCC pathogenesis and ICB resistance. This thesis investigates how these TANs affect MASH-HCC progression, and how the MASH TME in turn shapes TAN development and diversification. Overall, this thesis has outlined a novel mechanism by which TANs promoted immune evasion and tumour aggressiveness. It also highlighted the importance of understanding how cancer etiology impacts the immune response within the TME.During this investigation, two major types of datasets were generated. Firstly, single cell RNA-sequencing was performed on NRAS/AKT HCC-bearing mice bone marrow, spleen, and tumours (with or without aLy6G depletion). One sample of each was submitted for sequencing, and the resulting data is uploaded as feature-barcode matrices. Secondly, bulk RNA-seq of various experiments was performed, including: Transcriptomic profile of sort-purified TANs; Co-culture of RIL-175 HCC cells with sort-purified TANs; and Bone marrow neutrophils after overnight reprograming. Each experiment is available as count matrices, with the number of replicates indicated within the count matrix.
DOI: 10.25442/hku.27991631.v1
title: Supporting data for "Role of tumour associated neutrophils in metabolic dysfunction-associated hepatocellular carcinoma development"

description: This dataset accompanies the thesis submitted for PhD candidature by Teo Jia Ming Nickolas. The data is also available under the GEO accession GSE240840.The thesis regards the role of tumour associated neutrophils in metabolic dysfunction-associated hepatocellular carcinoma development. Neutrophils accumulate in solid tumours and their abundance are often associated with poor prognosis. Emerging evidence reveals that tumour-associated neutrophils (TANs) are highly heterogeneous, comprising of both pro- and anti-tumour subsets. Hence, TANs can differentially influence tumour progression and therapy efficacy depending on their diversity within the tumour microenvironment (TME). However, the factors driving TAN diversity, the functions of specific TAN subsets, and the spread of their heterogeneity in different cancer contexts remain largely unknown. Metabolic dysfunction-associated steatohepatitis (MASH) is the fastest growing cause of hepatocellular carcinoma (HCC). Crucially, despite abundant T cell infiltration, this fatty liver etiology is notoriously resistant towards immune checkpoint blockade (ICB) therapy. This treatment deficit likely arises from immunosuppressive factors in the TME. As neutrophils are one of the most prominent immune populations in the HCC TME, their diversity likely play key roles in MASH-HCC pathogenesis and ICB resistance. This thesis investigates how these TANs affect MASH-HCC progression, and how the MASH TME in turn shapes TAN development and diversification. Overall, this thesis has outlined a novel mechanism by which TANs promoted immune evasion and tumour aggressiveness. It also highlighted the importance of understanding how cancer etiology impacts the immune response within the TME.During this investigation, two major types of datasets were generated. Firstly, single cell RNA-sequencing was performed on NRAS/AKT HCC-bearing mice bone marrow, spleen, and tumours (with or without aLy6G depletion). One sample of each was submitted for sequencing, and the resulting data is uploaded as feature-barcode matrices. Secondly, bulk RNA-seq of various experiments was performed, including: Transcriptomic profile of sort-purified TANs; Co-culture of RIL-175 HCC cells with sort-purified TANs; and Bone marrow neutrophils after overnight reprograming. Each experiment is available as count matrices, with the number of replicates indicated within the count matrix.
DOI: 10.25442/hku.27932217
title: <b><i>Supporting data for</i></b> " The Establishment of Ovarian Follicles from Mouse Expanded Potential Stem Cells"

description: This is the supporting data for thesis entitled "The Establishment of Ovarian Follicles from Mouse Expanded Potential Stem Cells" . This study demonstrated for the first time the PGCLC and pre-GC differentiation potential of mEPSC. The modified stepwise protocol was shown efficiently differentiate male and female mEPSC into PGCLC. More importantly, female mEPSC-derived PGCLC were transcriptionally closer to <i>in-vivo</i> PGC when compared to those derived from female mESC. This study further demonstrated the inefficient pre-GC differentiation from mEPSC. The approach of pinpointing key pathways and the related drugs led to the discovery of two FDA-approved drugs that enhanced pre-GC differentiation from mEPSC. This file contains data supporting the above results.
DOI: 10.25442/hku.27932217.v1
title: <b><i>Supporting data for</i></b> " The Establishment of Ovarian Follicles from Mouse Expanded Potential Stem Cells"

description: This is the supporting data for thesis entitled "The Establishment of Ovarian Follicles from Mouse Expanded Potential Stem Cells" . This study demonstrated for the first time the PGCLC and pre-GC differentiation potential of mEPSC. The modified stepwise protocol was shown efficiently differentiate male and female mEPSC into PGCLC. More importantly, female mEPSC-derived PGCLC were transcriptionally closer to <i>in-vivo</i> PGC when compared to those derived from female mESC. This study further demonstrated the inefficient pre-GC differentiation from mEPSC. The approach of pinpointing key pathways and the related drugs led to the discovery of two FDA-approved drugs that enhanced pre-GC differentiation from mEPSC. This file contains data supporting the above results.
DOI: 10.25442/hku.27914190
title: Research data for the thesis "<b>The impact of sleep on lab-analogue trauma memory</b>"

description: Laboratory research data: The data consist of EEG recordings collected from 18 participants over 2 of sessions. The EEG data was collected using standardized methodologies for neuroscience research.All recordings will adhere to the 10-20 system for electrode placement to ensure consistencyand comparability with other EEG studies. During data collection, the equipment was becalibrated before each session to maintain data integrity, and environmental conditions (e.g.,noise, lighting) were controlled to reduce artifacts.
DOI: 10.25442/hku.27914190.v1
title: Research data for the thesis "<b>The impact of sleep on lab-analogue trauma memory</b>"

description: Laboratory research data: The data consist of EEG recordings collected from 18 participants over 2 of sessions. The EEG data was collected using standardized methodologies for neuroscience research.All recordings will adhere to the 10-20 system for electrode placement to ensure consistencyand comparability with other EEG studies. During data collection, the equipment was becalibrated before each session to maintain data integrity, and environmental conditions (e.g.,noise, lighting) were controlled to reduce artifacts.
DOI: 10.25442/hku.27977721
title: Supporting data for “Synthesized Complex-Frequency Waves for Optical Sensing and Superimaging”

description: This dataset supports the thesis titled “Synthesized Complex-Frequency Waves for Optical Sensing and Superimaging.” Synthesized complex-frequency waves (CFWs) represent an innovative method for loss compensation through the coherent combination of multiple real-frequency responses. Unlike other solutions such as gain materials and low-loss materials, the synthesized CFW method can be universally applied across various application scenarios without incurring additional experimental challenges and costs, thereby facilitating the study of light-matter interactions. This thesis investigates the physical mechanisms and mathematical principles underlying the synthesized CFW method, as well as its practical applications in optical sensing and superimaging. The dataset consists of two components: (1) mid-infrared spectra of various molecules and (2) superimaging results in the microwave frequency range, both of which are used to validate the effectiveness of our CFW method. The dataset is stored in .mat files and requires MATLAB software to be read.
DOI: 10.25442/hku.27977721.v1
title: Supporting data for “Synthesized Complex-Frequency Waves for Optical Sensing and Superimaging”

description: This dataset supports the thesis titled “Synthesized Complex-Frequency Waves for Optical Sensing and Superimaging.” Synthesized complex-frequency waves (CFWs) represent an innovative method for loss compensation through the coherent combination of multiple real-frequency responses. Unlike other solutions such as gain materials and low-loss materials, the synthesized CFW method can be universally applied across various application scenarios without incurring additional experimental challenges and costs, thereby facilitating the study of light-matter interactions. This thesis investigates the physical mechanisms and mathematical principles underlying the synthesized CFW method, as well as its practical applications in optical sensing and superimaging. The dataset consists of two components: (1) mid-infrared spectra of various molecules and (2) superimaging results in the microwave frequency range, both of which are used to validate the effectiveness of our CFW method. The dataset is stored in .mat files and requires MATLAB software to be read.
DOI: 10.15468/dl.huuyc5
title: Occurrence Download

description: A dataset containing 32 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is China",
 "TaxonKey is Calopogonium mucunoides Desv."
 ]
}

 The dataset includes 32 records from 10 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0049824-241126133413365/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.