cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.25573/data.10042577.v25
title: Agua Salud, Celestino Tower_Net Radiation 2 of 3

description: Agua Salud Celestino Tower, Net RadiationLocation 9.21142N, 79.72656W<br>Parameters: <br> albedo (soil albedo), 0-1 (statistics calculated only for data between 7am and 5pm)<br> dnwlwr (down-welling long wave radiation), W/m2<br> dnwsr (down-welling short wave radiation), W/m2<br> netlwr (net long wave radiation), W/m2<br> netswr (net short wave radiation), W/m2<br> netrad (net radiation), W/m2<br> radt (radiometer temperature), C<br> rdnwlwr (raw down-welling long wave radiation), W/m2<br> rupwlwr (raw upwelling long wave radiation), W/m2<br> upwlwr (upwelling long wave radiation), W/m2<br> upwswr (upwelling short wave radiation), W/m2<br> soilt (soil temperature), C<br><br>Established in 2015 and is located at the eastern edge of the Soberania Nation Park, in an area of pastures and forest patches. The tower is 40ft (12.2m) tall
DOI: 10.6084/m9.figshare.24967647
title: Supplementary Material for: Why Language Matters in Digital Endpoint Development: harmonized terminology as a key pre-requisite for evidence generation

description: Developments in the field of digital measures and endpoints derived from digital health technologies (DHTs) demand greater attention on harmonized approaches to enhance acceptance by regulatory authorities and health technology assessment bodies for decision making. As in any nascent field, greater alignment of concepts, definitions and terminology is required. This is a fast-moving complex area, every day brings new technologies, algorithms, and possibilities. A common language is particularly important when working in multifunctional teams and stakeholders to ensure that there is a clear understanding of what is meant and understood.

In the paper the EFPIA digital endpoint subgroup review the challenges facing teams working to advance digital endpoints: different terms used to describe the same things, common terms such as “monitoring” have significantly different meaning under different regulatory frameworks, the preface “e” denoting electronic and “digital” are used in different contexts and significant confusion as to what is understood by “raw” when it comes to data derived from DHTs.

The EFPIA subgroup is calling for an aligned lexicon across stakeholders and regulatory agencies such as FDA and EMA. The paper builds on established glossaries for the concepts of biomarkers, clinical outcome assessment and endpoints (e.g., BEST glossary). We propose where alignment is required and initiates discussion on those terms that are not established yet are important. Alignment provides a more predictable path for development, validation, and use of DHT-derived endpoints supporting standardization and consistency, with the goal of increasing regulatory and payer harmonization and acceptance.
DOI: 10.6084/m9.figshare.24967647.v1
title: Supplementary Material for: Why Language Matters in Digital Endpoint Development: harmonized terminology as a key pre-requisite for evidence generation

description: Developments in the field of digital measures and endpoints derived from digital health technologies (DHTs) demand greater attention on harmonized approaches to enhance acceptance by regulatory authorities and health technology assessment bodies for decision making. As in any nascent field, greater alignment of concepts, definitions and terminology is required. This is a fast-moving complex area, every day brings new technologies, algorithms, and possibilities. A common language is particularly important when working in multifunctional teams and stakeholders to ensure that there is a clear understanding of what is meant and understood.

In the paper the EFPIA digital endpoint subgroup review the challenges facing teams working to advance digital endpoints: different terms used to describe the same things, common terms such as “monitoring” have significantly different meaning under different regulatory frameworks, the preface “e” denoting electronic and “digital” are used in different contexts and significant confusion as to what is understood by “raw” when it comes to data derived from DHTs.

The EFPIA subgroup is calling for an aligned lexicon across stakeholders and regulatory agencies such as FDA and EMA. The paper builds on established glossaries for the concepts of biomarkers, clinical outcome assessment and endpoints (e.g., BEST glossary). We propose where alignment is required and initiates discussion on those terms that are not established yet are important. Alignment provides a more predictable path for development, validation, and use of DHT-derived endpoints supporting standardization and consistency, with the goal of increasing regulatory and payer harmonization and acceptance.
DOI: 10.5519/qd.wepdqscb
title: Query on the Natural History Museum Data Portal (data.nhm.ac.uk) (1955 records)
DOI: 10.5519/qd.7khmbvte
title: Query on the Natural History Museum Data Portal (data.nhm.ac.uk) (266 records)
DOI: 10.5281/zenodo.10473103
title: Measurement report: Vertical and temporal variability of near-surface ozone production rate and sensitivity in an urban area in Pearl River Delta (PRD) region, China

description: Understanding the near-ground vertical and temporal photochemical O3 formation mechanism is important to mitigate the O3 pollution. Here, we measured the vertical profiles of O3 and its precursors at six different heights from 5-335 m using a newly built vertical observation system in Pearl River Delta (PRD) region, China. The net photochemical ozone production rate (P(O3)net) and O3 formation sensitivities at various heights were diagnosed using an observation-based model coupled with the Master Chemical Mechanism (MCM v3.3.1). Moreover, for the assessment of model performance and the causative factors behind O3 pollution episodes, the net photochemical ozone production rate (P(O3)net) was measured at 5 m ground level utilizing a custom-built detection system. In total three O3 pollution episodes and two non-episodes were captured. The identified O3 pollution episodes were found to be jointly influenced by both photochemical production and physical transport, with local photochemical reactions play a dominate role. The high index of agreement (IOA) calculated from comparing the modelled and measured P(O3)net values indicated the rationality to investigate the vertical and temporal variability of O3 formation mechanism using modelling results. However, the measured P(O3)net values were generally higher than the modelled P(O3)net values, particularly under high NOx conditions, which may indicate a potential underestimation of total RO2 by the model. Throughout the measurement period, the contribution of different reaction pathways to O3 production remained consistent across various heights, with HO2+NO as the major O3 production pathway, followed by RO2+NO. We saw P(O3)net decreased with the increase of the measurement height, primarily attributed to the decreased O3 precursors anthropogenic organic compounds (AVOC) and oxygenated volatile organic compounds (OVOC). O3 formation regimes were similar at different heights during both episodes and non-episodes, which was located either in volatile organic compounds (VOCs) sensitive regime or in transition regime and more sensitive to VOCs. Diurnally, photochemical O3 formation typically remained in the VOCs sensitive regime during the morning and noon time, but in the transitional regime and more sensitive to VOCs in the afternoon at around 16:00 LT. The vertical and temporal O3 formation are most sensitive to AVOC and OVOC, which suggests that targeting VOCs, especially AVOC and OVOC, for control measures is more practical and feasible at the observation site. The vertical temporal analysis of O3 formation mechanisms near the ground surface in this study provides critical foundational knowledge for formulating effective short-term emergency and long-term strategies to combat O3 pollution in the PRD region of China.
DOI: 10.5281/zenodo.10473104
title: Measurement report: Vertical and temporal variability of near-surface ozone production rate and sensitivity in an urban area in Pearl River Delta (PRD) region, China

description: Understanding the near-ground vertical and temporal photochemical O3 formation mechanism is important to mitigate the O3 pollution. Here, we measured the vertical profiles of O3 and its precursors at six different heights from 5-335 m using a newly built vertical observation system in Pearl River Delta (PRD) region, China. The net photochemical ozone production rate (P(O3)net) and O3 formation sensitivities at various heights were diagnosed using an observation-based model coupled with the Master Chemical Mechanism (MCM v3.3.1). Moreover, for the assessment of model performance and the causative factors behind O3 pollution episodes, the net photochemical ozone production rate (P(O3)net) was measured at 5 m ground level utilizing a custom-built detection system. In total three O3 pollution episodes and two non-episodes were captured. The identified O3 pollution episodes were found to be jointly influenced by both photochemical production and physical transport, with local photochemical reactions play a dominate role. The high index of agreement (IOA) calculated from comparing the modelled and measured P(O3)net values indicated the rationality to investigate the vertical and temporal variability of O3 formation mechanism using modelling results. However, the measured P(O3)net values were generally higher than the modelled P(O3)net values, particularly under high NOx conditions, which may indicate a potential underestimation of total RO2 by the model. Throughout the measurement period, the contribution of different reaction pathways to O3 production remained consistent across various heights, with HO2+NO as the major O3 production pathway, followed by RO2+NO. We saw P(O3)net decreased with the increase of the measurement height, primarily attributed to the decreased O3 precursors anthropogenic organic compounds (AVOC) and oxygenated volatile organic compounds (OVOC). O3 formation regimes were similar at different heights during both episodes and non-episodes, which was located either in volatile organic compounds (VOCs) sensitive regime or in transition regime and more sensitive to VOCs. Diurnally, photochemical O3 formation typically remained in the VOCs sensitive regime during the morning and noon time, but in the transitional regime and more sensitive to VOCs in the afternoon at around 16:00 LT. The vertical and temporal O3 formation are most sensitive to AVOC and OVOC, which suggests that targeting VOCs, especially AVOC and OVOC, for control measures is more practical and feasible at the observation site. The vertical temporal analysis of O3 formation mechanisms near the ground surface in this study provides critical foundational knowledge for formulating effective short-term emergency and long-term strategies to combat O3 pollution in the PRD region of China.
DOI: 10.6084/m9.figshare.24960543
title: Supplementary Material for: International online survey on the management of patent ductus arteriosus

description: Introduction
There is uncertainty and lack of consensus regarding optimal management of patent ductus arteriosus (PDA). We aimed to determine current clinical practice in PDA management across a range of different regions internationally.
Materials and Methods
We surveyed PDA management practices in neonatal intensive care units using a pre-piloted web-based survey, which was distributed to perinatal societies in 31 countries. The survey was available online from March 2018 to March 2019. 
Results
There were 812 responses. The majority of clinicians (54%) did not have institutional protocols for PDA treatment and 42% reported variable management within their own unit. Among infants &lt;28 weeks (or &lt;1000g), most clinicians (60%) treat symptomatically. Respondents in Australasia were more likely to treat PDA pre-symptomatically (44% vs 18% all countries [OR 4.1; 95% CI 2.6-6.5; p&lt;0.001]) and respondents from North America were more likely to treat symptomatic PDA (67% vs 60% all countries [OR 2.0; 95% CI 1.5-2.6; p&lt;0.001]). In infants ≥28 weeks (or ≥1000g), most clinicians (54%) treat symptomatically. Respondents in North America were more likely to treat PDAs in this group of infants conservatively (47% vs 38% all countries [OR 2.3; 95% CI 1.7-3.2]; p&lt;0.001) and respondents from Asia were more likely to treat the PDA pre-symptomatically (21% vs 7% all countries [OR 5.5; 95% CI 3.2-9.8; p&lt;0.001]).
Discussion/Conclusion
There were marked international differences in clinical practice, highlighting ongoing uncertainty and a lack of consensus regarding PDA management. An international conglomeration to coordinate research that prioritises and addresses these areas of contention is indicated.
DOI: 10.5281/zenodo.10491816
title: THE ROLE OF DISTANCE LEARNING IN TEACHING PROCESS
DOI: 10.5281/zenodo.10491815
title: THE ROLE OF DISTANCE LEARNING IN TEACHING PROCESS
DOI: 10.25573/data.10042595.v24
title: Culebra_Wind Speed

description: Punta Culebra Nature Center meteorological station. Established in 2002. <br>Location: 8.910718°N, -79.528919°Wind Speed, interval max/min/avg
DOI: 10.6084/m9.figshare.24828549.v1
title: Supplementary Material for: The Effect of The Oral Iron Chelator Deferiprone on Iron Overload and Oxidative Stress in Patients with Myelodysplastic Syndromes A Study by the Israeli MDS Working Group

description: Background: Most patients with lower risk myelodysplastic neoplasms (MDS) become RBC transfusion-dependent, resulting in iron overload, which is associated with an increased oxidative stress state. Iron-chelation therapy is applied to attenuate the toxic effects of this state. Deferiprone (DFP) is an oral iron chelator, which is not commonly used in this patient population, due to safety concerns, mainly agranulocytosis. The purpose of this study was to assess the effect of DFP, on oxidative stress parameters in iron overloaded RBC transfusion-dependent patients with lower risk MDS. 
Methods: Adult lower-risk MDS patients with a cumulative transfusion burden of &gt;20 red blood cells units and evidence of iron overload (serum ferritin &gt;1,000 ng/mL) were included in this study. DFP was administered (100 mg/kg/day) for 4 months. Blood samples for oxidative stress parameters and iron overload parameters were done at baseline and monthly: reactive oxygen species (ROS), phosphatidylserine, reduced glutathione, membrane lipid peroxidation, serum ferritin and cellular labile iron pool. The primary efficacy variable was ROS. Tolerability and side-effects were recorded as well. A paired t-test was applied for statistical analyses. 
Results: Eighteen patients were treated with DFP. ROS significantly decreased in all cell lineages: median decrease of 58.6% in RBC, 33.3% in PMN, and 39.8% in platelets (p&lt;0.01 for all). Other oxidative stress markers improved: phosphatidylserine decreased by 57.95%, lipid peroxidase decreased by 141.3%, and reduced gluthathione increased by 72.8% (p&lt;0.01 for all). The iron-overload marker, cellular labile iron pool, decreased by 35% in RBCs, 44.3% in PMN, and 46.3% in platelets (p&lt;0.01 for all). No significant changes were observed in SF levels. There were no events of agranulocytosis. All AEs were grade 1-2. 
Conclusions: Herein we showed preliminary evidence that DFP decreases iron-induced oxidative stress in MDS patients with a good tolerability profile (albeit a short follow-up period). No cases of severe neutropenia or agranulocytosis were reported. The future challenge is to prove that reduction in iron toxicity will eventually be translated into a clinically meaningful improvement.
DOI: 10.25573/data.10042610.v24
title: Culebra_Air Temperature

description: Punta Culebra Nature Center meteorological station. Established in 2002. <br>Location: 8.910718°N, -79.528919°<br>Temperature, interval max/min/avg<br>
DOI: 10.25573/data.10042598.v24
title: Culebra_Relative Humidity

description: Punta Culebra Nature Center meteorological station. Established in 2002. <br>Location: 8.910718°N, -79.528919°<br>Relative Humidity, interval max/min/avg<br>
DOI: 10.25573/data.10042586.v24
title: Culebra_Precipitation

description: Punta Culebra Nature Center meteorological station. Established in 2002. <br>Location: 8.910718°N, -79.528919°<br>Precipitation, interval total
DOI: 10.5281/zenodo.10491826
title: COBALT FISCHER–TROPSCH CATALYST REGENERATION
DOI: 10.5281/zenodo.10491827
title: COBALT FISCHER–TROPSCH CATALYST REGENERATION
DOI: 10.6084/m9.figshare.24845298
title: Supplementary Material for: Determinants of urine output using advanced hemodynamic monitoring in critically ill patients undergoing continuous renal replacement therapy

description: Introduction: Low cardiac output and hypovolemia are candidate macrocirculatory mechanisms explanatory of de novo anuria in ICU patients undergoing continuous renal replacement therapy (CRRT). We aimed to determine the hemodynamic parameters and CRRT settings associated with the longitudinal course of UO during CRRT.
Methods: This is an ancillary analysis of the PRELOAD CRRT observational, single-center study (NCT03139123). Enrolled adult patients had severe acute kidney injury treated with CRRT for less than 24h, and were monitored with a calibrated continuous cardiac output monitoring device. Hemodynamics (including stroke volume index [SVI] and preload-dependence, identified by continuous cardiac index variation during postural maneuvers), net ultrafiltration (UFNET) and UO were reported 4-hourly, over 7 days. Two study groups were defined at inclusion: non-anuric participants if the cumulative 24h UO at inclusion was ≥0.05 ml.kg-1.h-1, and anuric otherwise. Quantitative data was reported by its median [interquartile range]. 
Results: Forty-two patients (age 68 [58–76] years) were enrolled. At inclusion, 32 patients (76%) were not anuric. During follow-up, UO decreased significantly in non-anuric patients, with 25/32 (78%) progressing to anuria within 19 [10–50] hours. Mean arterial pressure (MAP) and UFNET did not significantly differ between study groups during follow-up, while SVI and preload-dependence were significantly associated with the interaction of study group and time since inclusion. Higher UFNET flow rates were significantly associated with higher systemic vascular resistances and lower cardiac output during follow-up. Multivariate analyses showed that 1/ lower UO was significantly associated with lower SVI, lower MAP, and preload-independence; and 2/ higher UFNET was significantly associated with lower UO.
Conclusions: In ICU patients treated with CRRT, those without anuria showed a rapid loss of diuresis after CRRT initiation. Hemodynamic indicators of renal perfusion and effective volemia were the principal determinants of UO during follow-up, in relation with the hemodynamic impact of UFNET setting.
DOI: 10.6084/m9.figshare.24845298.v1
title: Supplementary Material for: Determinants of urine output using advanced hemodynamic monitoring in critically ill patients undergoing continuous renal replacement therapy

description: Introduction: Low cardiac output and hypovolemia are candidate macrocirculatory mechanisms explanatory of de novo anuria in ICU patients undergoing continuous renal replacement therapy (CRRT). We aimed to determine the hemodynamic parameters and CRRT settings associated with the longitudinal course of UO during CRRT.
Methods: This is an ancillary analysis of the PRELOAD CRRT observational, single-center study (NCT03139123). Enrolled adult patients had severe acute kidney injury treated with CRRT for less than 24h, and were monitored with a calibrated continuous cardiac output monitoring device. Hemodynamics (including stroke volume index [SVI] and preload-dependence, identified by continuous cardiac index variation during postural maneuvers), net ultrafiltration (UFNET) and UO were reported 4-hourly, over 7 days. Two study groups were defined at inclusion: non-anuric participants if the cumulative 24h UO at inclusion was ≥0.05 ml.kg-1.h-1, and anuric otherwise. Quantitative data was reported by its median [interquartile range]. 
Results: Forty-two patients (age 68 [58–76] years) were enrolled. At inclusion, 32 patients (76%) were not anuric. During follow-up, UO decreased significantly in non-anuric patients, with 25/32 (78%) progressing to anuria within 19 [10–50] hours. Mean arterial pressure (MAP) and UFNET did not significantly differ between study groups during follow-up, while SVI and preload-dependence were significantly associated with the interaction of study group and time since inclusion. Higher UFNET flow rates were significantly associated with higher systemic vascular resistances and lower cardiac output during follow-up. Multivariate analyses showed that 1/ lower UO was significantly associated with lower SVI, lower MAP, and preload-independence; and 2/ higher UFNET was significantly associated with lower UO.
Conclusions: In ICU patients treated with CRRT, those without anuria showed a rapid loss of diuresis after CRRT initiation. Hemodynamic indicators of renal perfusion and effective volemia were the principal determinants of UO during follow-up, in relation with the hemodynamic impact of UFNET setting.
DOI: 10.25573/data.10042604.v24
title: Culebra_Solar Radiation, Pyranometer

description: Punta Culebra Nature Center meteorological station. Established in 2002. <br>Location: 8.910718°N, -79.528919°<br>Solar Radiation (Pyranometer), interval max/min/avg<br>
DOI: 10.25573/data.10042622.v24
title: Culebra_Wind Direction

description: Punta Culebra Nature Center meteorological station. Established in 2002. <br>Location: 8.910718°N, -79.528919°<br>Wind Direction, interval mean vector, standard deviation<br>
DOI: 10.25573/data.10042619.v15
title: Fortuna, Clearing_Precipitation

description: Fortuna station (Centro de Investigaciones Jorge L. Arauz)<br>South Clearing<br>Location: 8° 43.340'N, 82° 14.241'W<br>Precipitation, Daily total<br><br>Located in the highlands of the Chiriqui Province, in western Panama.There are three sensor locations: north clearing, south clearing, and a 15m tower.<br>
DOI: 10.25573/data.10042607
title: Fortuna, Clearing_Air Temperature

description: Fortuna station (Centro de Investigaciones Jorge L. Arauz)<br>North Clearing shelter<br>Location: 8° 43.340'N, 82° 14.241'W<br>Air Temperature, Interval value<br><br>Located in the highlands of the Chiriqui Province, in western Panama.There are three sensor locations: north clearing, south clearing, and a 15m tower.<br>
DOI: 10.25573/data.10042607.v8
title: Fortuna, Clearing_Air Temperature

description: Fortuna station (Centro de Investigaciones Jorge L. Arauz)<br>North Clearing shelter<br>Location: 8° 43.340'N, 82° 14.241'W<br>Air Temperature, Interval value<br><br>Located in the highlands of the Chiriqui Province, in western Panama.There are three sensor locations: north clearing, south clearing, and a 15m tower.<br>
DOI: 10.25573/data.10042607.v7
title: Fortuna, Clearing_Air Temperature

description: Fortuna station (Centro de Investigaciones Jorge L. Arauz)<br>North Clearing shelter<br>Location: 8° 43.340'N, 82° 14.241'W<br>Air Temperature, Interval value<br><br>Located in the highlands of the Chiriqui Province, in western Panama.There are three sensor locations: north clearing, south clearing, and a 15m tower.<br>