DOI: 10.5061/dryad.jm63xsjhj
title: Data from: de-stabilizing innate immunity in Covid-19: effects of its own positive feedback and erratic viremia on the alternative pathway of complement

description: Complement provides powerful, fast responses in the human circulation to
 SARS-CoV-2 (Covid-19 virus) infection of the lower respiratory tract.
 Covid-19 effects were investigated in a revised human in silico Mass
 Action model of Complement’s Alternative pathway (AP) responses. Bursts of
 newly circulating virions increased the fission of Complement protein C3
 into C3a and C3b via stimulation of the lectin pathway or inhibited
 Complement factor H. Viral reproduction sub-models incorporated smoothly
 exponential or step-wise exponential growth. Starting complement protein
 concentrations were drawn randomly from published normal male or female
 ranges and each infection model run for 10 days. C3 and factor B (FB)
 syntheses driven by Lectin Pathway stimulation led to declining plasma C3
 and increasing FB concentrations. The C3 convertase concentration, a
 driver of viral elimination, could match viral growth over three orders of
 magnitude but near-complete exhaustion of circulating C3 was more
 prevalent with step-wise than with “smooth” increases in viral
 stimulation. C3 exhaustion could be prolonged. Type 2 Diabetes and
 hypertension led to greatly increased peak C3 convertase concentrations,
 as did short-term variability of Covid-19 viremia, pulmonary capillary
 clotting and secondary acidosis. Positive feedback in the Alternative
 pathway greatly extends its response range at the expense of stability.
description: The data was collected over a half century by many scientists and
 published in the available literature. It includes normal protein
 concentrations with their inter-individual variability (statistical
 distributions, where available). Also included are data on enzyme kinetics
 related to the processing of these proteins in health and
 disease.
description: # Data from: de-stabilizing innate immunity in Covid-19: effects of its
 own positive feedback and erratic viremia on the alternative pathway of
 complement
 [https://doi.org/10.5061/dryad.jm63xsjhj](https://doi.org/10.5061/dryad.jm63xsjhj) ## Description of the data and file structure Each jmp file (except the two stubs) contains data representing the evolution over 10 days of modelled alternative pathway protein concentrations in the the human extracellular fluid of one simulated male or female person, either in the healthy steady state or during stimulation via the simulated lectin pathway (or after reduction in simulated factor H concentration) provoked by SARS-Cov2 infection. The individual files are labelled as follows (see "Description of Variables in JMP Spreadsheets.pdf" file for definitions): PR = progressive (exponential growth of coronavirus); SW = Stepwise - mostly tenfold - "instantaneous" growth of coronavirus, per 2 days (along an exponential 10-fold per two day pathway) see model description in Methods); First, Second, Third etc when each simulation was repeated twenty times to model inter-individual variation, each simulation was given a serial number; Male, Female indicates starting values derived from sex specific data; in the event of clotting being programmed the number following "clotting" defines the proportion, as the reciprocal of this number, of the infected lobules remaining patent after a clotting event. ###### NB do NOT remove/add rows or random changes will occur in JMP ## Code/Software JMP13