cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.9899978
title: Potential of Baccharis alnifolia Meyen & Walpan (Chilka) from northern Chile used as a medicinal infusion

description: ABSTRACT: Baccharis alnifolia Meyen & Walp. is a native and medicinal, Chilean Altiplano herb that is used as a poultice and also consumed as an infusion to relieve inflammation. This study evaluated the antioxidant and cytotoxic effect of the ethanolic extract of B. alnifolia and their infusion. It was reported that the ethanol extract contains 4.42 mg GAE/g of dry weight and the infusion contains 35.86 mg GAE/L of total polyphenols. Also, it determined the antioxidant capacity using Ferric reducing antioxidant power (FRAP), Oxygen Radical Absorbance Capacity (ORAC) and Trolox equivalent antioxidant capacity (TEAC) assay. Moreover, seven metabolites including between phenolic acids and flavonoids were identified for the first time in both extracts of the medicinal plant Baccharis alnifolia. The UHPLC-DAD chromatograms revealed the majority presence of ferulic acid and luteolin, both could be responsible for the antioxidant and cytotoxic activity. Furthermore, we realized a preliminary screening of cytotoxicity in different tumor cell lines, finding that these extracts have cytotoxic potential on kidney cells.
DOI: 10.6084/m9.figshare.9899993.v1
title: EDGE EFFECT ON CHEMICAL ATTRIBUTES OF SOIL IN A SEASONAL FOREST

description: ABSTRACT The magnitude of changes in soil attributes can be used to identify the effects of natural or anthropogenic interference on forest fragments. The objective of this work was to evaluate the chemical attributes of the soil as indicators of the edge effect at a Seasonal Semi-deciduous Forest fragment in the Southwest of Bahia, Brazil. Four sampling ranges were defined in the forest fragment (Range 1: 0-10m; Range 2: 40-50 m; Range 3: 80-90 m; and Range 4: 400-410 m from the edge). A degraded native pasture area was used as the reference. Soil samples were collected at depths of 0-5, 5-10 and 10-20 cm. The samples were analyzed for pH and organic matter, P, K, Ca, Mg and Al. The superficial layer of the soil was sensitive to the changes imposed by the fragmentation, reflecting modifications in some of its chemical attributes up to a distance of 90 m from the edge towards the interior of the fragment, with more severe effects in the first 10 meters. Soil organic matter, potential acidity, CEC and pH were the most affected attributes, evidencing a gradient of variation in the edge-interior direction.
DOI: 10.6084/m9.figshare.9899978.v1
title: Potential of Baccharis alnifolia Meyen & Walpan (Chilka) from northern Chile used as a medicinal infusion

description: ABSTRACT: Baccharis alnifolia Meyen & Walp. is a native and medicinal, Chilean Altiplano herb that is used as a poultice and also consumed as an infusion to relieve inflammation. This study evaluated the antioxidant and cytotoxic effect of the ethanolic extract of B. alnifolia and their infusion. It was reported that the ethanol extract contains 4.42 mg GAE/g of dry weight and the infusion contains 35.86 mg GAE/L of total polyphenols. Also, it determined the antioxidant capacity using Ferric reducing antioxidant power (FRAP), Oxygen Radical Absorbance Capacity (ORAC) and Trolox equivalent antioxidant capacity (TEAC) assay. Moreover, seven metabolites including between phenolic acids and flavonoids were identified for the first time in both extracts of the medicinal plant Baccharis alnifolia. The UHPLC-DAD chromatograms revealed the majority presence of ferulic acid and luteolin, both could be responsible for the antioxidant and cytotoxic activity. Furthermore, we realized a preliminary screening of cytotoxicity in different tumor cell lines, finding that these extracts have cytotoxic potential on kidney cells.
DOI: 10.6084/m9.figshare.9899969
title: Adjustable sling for the treatment of post-prostatectomy urinary incontinence: systematic review and meta-analysis

description: ABSTRACT Urinary incontinence after prostatectomy has a significant negative impact on the quality of life of the patient. The surgical treatment includes several models of male slings, such as adjustable slings. The objective of this study was to evaluate the effectiveness and safety of adjustable sling in the treatment of post-prostatectomy urinary incontinence. This is a systematic review of literature. The following electronic databases were searched until January 2018: PubMed®, Embase, CENTRAL and LILACS. The keywords used in the search strategies were: “prostatectomy” [Mesh], “urinary incontinence” [Mesh] and “suburethral slings” [Mesh]. Randomized clinical trials and observational studies, with or without Control Group, and follow-up of more than 12 months were included. Only one randomized study with high risk of bias was included and it concluded the effectiveness equivalence between adjustable and non-adjustable slings. All other studies were cases series with patients of varying levels of incontinence intensity and history of pelvic radiation therapy and previous surgeries. The meta-analysis for 0 pad in 24 hours demonstrated an effectiveness of 53%. For the 0 to 1 pad test in 24 hours, the meta-analysis resulted in an effectiveness of 69%. Risk factors for surgery failure include prior radiation, severity of post-prostatectomy urinary incontinence, and previous surgeries. The meta-analysis of the extrusion rate was 9.8% and the most commonly reported adverse effects were pain and local infection. Evidence of low quality indicates that adjustable slings are effective for treating post-prostatectomy urinary incontinence, with frequency of adverse events similar to the surgical option considered gold standard (the artificial urinary sphincter implant).
DOI: 10.6084/m9.figshare.9899972.v1
title: Calpains of Leishmania braziliensis: genome analysis, differential expression, and functional analysis

description: BACKGROUND Calpains are proteins belonging to the multi-gene family of calcium-dependent cysteine peptidases that undergo tight on/off regulation, and uncontrolled proteolysis of calpains is associated with severe human pathologies. Calpain orthologues are expanded and diversified in the trypanosomatids genome. OBJECTIVES Here, we characterised calpains in Leishmania braziliensis, the main causative agent of cutaneous leishmaniasis in Brazil. METHODS/FINDINGS In total, 34 predicted calpain-like genes were identified. After domain structure evaluation, reverse transcription-quantitative polymerase chain reaction (RT-qPCR) during in vitro metacyclogenesis revealed (i) five genes with enhanced expression in the procyclic stage, (ii) one augmented gene in the metacyclic stage, and (iii) one procyclic-exclusive transcript. Western blot analysis revealed that an antibody against a consensus-conserved peptide reacted with multiple calpain-like proteins, which is consistent with the multi-gene family characteristic. Flow cytometry and immunocytochemistry analyses revealed the presence of calpain-like molecules mainly in the cytoplasm, to a lesser extent in the plasma membrane, and negligible levels in the nucleus, which are all consistent with calpain localisation. Eventually, the calpain inhibitor MDL28170 was used for functional studies revealing (i) a leishmaniostatic effect, (ii) a reduction in the association index in mouse macrophages, (iii) ultra-structural alterations conceivable with autophagy, and (iv) an enhanced expression of the virulence factor GP63. CONCLUSION This report adds novel insights into the domain structure, expression, and localisation of L. braziliensis calpain-like molecules.
DOI: 10.6084/m9.figshare.9899960
title: Liaisons dangereuses: cross-border gene flow and dispersal of insecticide resistance-associated genes in the mosquito Aedes aegypti from Brazil and French Guiana

description: BACKGROUND In recent years, South America has suffered the burden of continuous high impact outbreaks of dengue, chikungunya and Zika. Aedes aegypti is the main mosquito vector of these arboviruses and its control is the only solution to reduce transmission. OBJECTIVES In order to improve vector control it is essential to study mosquito population genetics in order to better estimate the population structures and the geneflow among them. METHODS We have analysed microsatellites and knockdown resistance (kdr) mutations from a trans-border region in Amazonia between the state of Amapá (Brazil) and French Guiana (overseas territory of France), to provide further knowledge on these issues. These two countries have followed distinct vector control policies since last century. For population genetic analyses we evaluated variability in 13 well-established microsatellites loci in Ae. aegypti from French Guiana (Saint Georges and Cayenne) and Brazil (Oiapoque and Macapá). The occurrence and frequency of kdr mutations in these same populations were accessed by TaqMan genotype assays for the sites 1016 (Val/Ile) and 1534 (Phe/Cys). FINDINGS We have detected high levels of gene flow between the closest cross-border samples of Saint-Georges and Oiapoque. These results suggest one common origin of re-colonisation for the populations of French Guiana and Oiapoque in Brazil, and a different source for Macapá, more similar to the other northern Brazilian populations. Genotyping of the kdr mutations revealed distinct patterns for Cayenne and Macapá associated with their different insecticide use history, and an admixture zone between these two patterns in Saint Georges and Oiapoque, in accordance with population genetic results. MAIN CONCLUSIONS The present study highlights the need for regional-local vector surveillance and transnational collaboration between neighboring countries to assess the impact of implemented vector control strategies, promote timely actions and develop preparedness plans.
DOI: 10.6084/m9.figshare.9899969.v1
title: Adjustable sling for the treatment of post-prostatectomy urinary incontinence: systematic review and meta-analysis

description: ABSTRACT Urinary incontinence after prostatectomy has a significant negative impact on the quality of life of the patient. The surgical treatment includes several models of male slings, such as adjustable slings. The objective of this study was to evaluate the effectiveness and safety of adjustable sling in the treatment of post-prostatectomy urinary incontinence. This is a systematic review of literature. The following electronic databases were searched until January 2018: PubMed®, Embase, CENTRAL and LILACS. The keywords used in the search strategies were: “prostatectomy” [Mesh], “urinary incontinence” [Mesh] and “suburethral slings” [Mesh]. Randomized clinical trials and observational studies, with or without Control Group, and follow-up of more than 12 months were included. Only one randomized study with high risk of bias was included and it concluded the effectiveness equivalence between adjustable and non-adjustable slings. All other studies were cases series with patients of varying levels of incontinence intensity and history of pelvic radiation therapy and previous surgeries. The meta-analysis for 0 pad in 24 hours demonstrated an effectiveness of 53%. For the 0 to 1 pad test in 24 hours, the meta-analysis resulted in an effectiveness of 69%. Risk factors for surgery failure include prior radiation, severity of post-prostatectomy urinary incontinence, and previous surgeries. The meta-analysis of the extrusion rate was 9.8% and the most commonly reported adverse effects were pain and local infection. Evidence of low quality indicates that adjustable slings are effective for treating post-prostatectomy urinary incontinence, with frequency of adverse events similar to the surgical option considered gold standard (the artificial urinary sphincter implant).
DOI: 10.6084/m9.figshare.9899951
title: Reinforced concrete corbels strengthened with external prestressing

description: Abstract Reinforced concrete structures may demand, throughout their lifetime, the increase of the capacity load due to eventual changes in the load configuration. In this context, corbels could be considered structural elements which present great challenges for installing strengthening solutions. The referred difficulty is due to the fact that the strength capacity of this kind of element is dependent on the strength of a diagonal concrete strut and a tensile steel tie, both located in a very short region also subjected to interferences. In the present paper, the behavior of reinforced concrete corbels strengthened with external prestressing is investigated. For that, nonlinear analysis of short corbels (a/d ratio between 0,5 and 1,0), strengthened or not, have been applied. Also, analytical models based on the Strut-and-Tie Model were developed and the obtained results were compared with experimental results. The obtained results have demonstrated that strengthening reinforced concrete corbels using external prestressing is a fast, efficient and safe solution.
DOI: 10.6084/m9.figshare.9899957
title: Impact of the inclusion of variable CO2 cost in the distribution network design

description: Abstract Paper aims This study aims to evaluate the economic-financial impact that the inclusion of environmental variable CO2 cost attributed to transportation (fuel consumption) and manufacturing activities (electricity consumption) represents in a distribution network optimization design. Originality This is the first work carried out in Brazil to present a feasible eco-efficient distribution network in the technical and economic aspects considering the tax aspects of ICMS. In addition, this work addresses the inclusion of CO2 as a cost associated with transportation and manufacturing activities. Finally, for the first time in literature, a reference framework that considers environmental variables is presented. Research method This study used the systematic literature review method to review the referential framework and carried out a cost reduction using specialist optimization software. Main findings The technical and economical feasibility in achieving reduction of both total logistic and CO2 costs in a distribution network design in Brazil and the inexistence of trade-offs without technical solution to the eco-efficient configuration of the distribution network. Implications for theory and practice The results of this paper presents a relevant contribution to logistics professionals and researchers, as it was able to present a framework and demonstrated the feasibility of an eco-efficient network design.
DOI: 10.6084/m9.figshare.9899951.v1
title: Reinforced concrete corbels strengthened with external prestressing

description: Abstract Reinforced concrete structures may demand, throughout their lifetime, the increase of the capacity load due to eventual changes in the load configuration. In this context, corbels could be considered structural elements which present great challenges for installing strengthening solutions. The referred difficulty is due to the fact that the strength capacity of this kind of element is dependent on the strength of a diagonal concrete strut and a tensile steel tie, both located in a very short region also subjected to interferences. In the present paper, the behavior of reinforced concrete corbels strengthened with external prestressing is investigated. For that, nonlinear analysis of short corbels (a/d ratio between 0,5 and 1,0), strengthened or not, have been applied. Also, analytical models based on the Strut-and-Tie Model were developed and the obtained results were compared with experimental results. The obtained results have demonstrated that strengthening reinforced concrete corbels using external prestressing is a fast, efficient and safe solution.
DOI: 10.6084/m9.figshare.9899957.v1
title: Impact of the inclusion of variable CO2 cost in the distribution network design

description: Abstract Paper aims This study aims to evaluate the economic-financial impact that the inclusion of environmental variable CO2 cost attributed to transportation (fuel consumption) and manufacturing activities (electricity consumption) represents in a distribution network optimization design. Originality This is the first work carried out in Brazil to present a feasible eco-efficient distribution network in the technical and economic aspects considering the tax aspects of ICMS. In addition, this work addresses the inclusion of CO2 as a cost associated with transportation and manufacturing activities. Finally, for the first time in literature, a reference framework that considers environmental variables is presented. Research method This study used the systematic literature review method to review the referential framework and carried out a cost reduction using specialist optimization software. Main findings The technical and economical feasibility in achieving reduction of both total logistic and CO2 costs in a distribution network design in Brazil and the inexistence of trade-offs without technical solution to the eco-efficient configuration of the distribution network. Implications for theory and practice The results of this paper presents a relevant contribution to logistics professionals and researchers, as it was able to present a framework and demonstrated the feasibility of an eco-efficient network design.
DOI: 10.6084/m9.figshare.9899960.v1
title: Liaisons dangereuses: cross-border gene flow and dispersal of insecticide resistance-associated genes in the mosquito Aedes aegypti from Brazil and French Guiana

description: BACKGROUND In recent years, South America has suffered the burden of continuous high impact outbreaks of dengue, chikungunya and Zika. Aedes aegypti is the main mosquito vector of these arboviruses and its control is the only solution to reduce transmission. OBJECTIVES In order to improve vector control it is essential to study mosquito population genetics in order to better estimate the population structures and the geneflow among them. METHODS We have analysed microsatellites and knockdown resistance (kdr) mutations from a trans-border region in Amazonia between the state of Amapá (Brazil) and French Guiana (overseas territory of France), to provide further knowledge on these issues. These two countries have followed distinct vector control policies since last century. For population genetic analyses we evaluated variability in 13 well-established microsatellites loci in Ae. aegypti from French Guiana (Saint Georges and Cayenne) and Brazil (Oiapoque and Macapá). The occurrence and frequency of kdr mutations in these same populations were accessed by TaqMan genotype assays for the sites 1016 (Val/Ile) and 1534 (Phe/Cys). FINDINGS We have detected high levels of gene flow between the closest cross-border samples of Saint-Georges and Oiapoque. These results suggest one common origin of re-colonisation for the populations of French Guiana and Oiapoque in Brazil, and a different source for Macapá, more similar to the other northern Brazilian populations. Genotyping of the kdr mutations revealed distinct patterns for Cayenne and Macapá associated with their different insecticide use history, and an admixture zone between these two patterns in Saint Georges and Oiapoque, in accordance with population genetic results. MAIN CONCLUSIONS The present study highlights the need for regional-local vector surveillance and transnational collaboration between neighboring countries to assess the impact of implemented vector control strategies, promote timely actions and develop preparedness plans.
DOI: 10.6084/m9.figshare.9899942
title: Peach palm flour (Bactris gasipae KUNTH): potential application in the food industry

description: Abstract Peach palm flours prepared from the landraces microcarpa (MIF), mesocarpa (MEF), and macrocarpa (MAF) were assessed for their functional and morphological characteristics. The flours had moisture contents in accordance with the current legislation, considerable lipid (≥3.95%) and carbohydrate (≥66.68%) contents, and potential as an energy source (≥300 kcal/100 g). MEF and MAF can be considered rich in dietary fibers since their fiber contents were above 6 g/100 g, which contributes to the nutritional enrichment of products prepared with those flours. The assessment of the technological properties, WAC (≥255%) and OAC (≥65%) showed the peach palm flours can be used as raw material in different products such as breads, cakes, meat products, and breaded foods, thus adding energy, nutritional, and economic value. It is worth pointing out that peach palm is gluten free, hence it is an option for the development of new products targeted at consumers with celiac disease.
DOI: 10.6084/m9.figshare.9899945
title: The electric boat charging problem

description: Abstract Paper aims This paper studies a new optimization problem called the Electric Boat Charging Problem (EBCP), which is based on the application of electric mobility in a river transport operation problem. Originality This work pioneers the studies of the electric mobility on the river operations, by proposing the EBCP. This problem includes real features of the electric mobility such as nonlinear charging functions, battery degradation costs, and speed variation. Research method For solving the EBCP, we propose a Mixed-Integer Linear Programming (MILP) formulation. For testing our MILP formulation, we use a set of instances based on a future transport operation. We also analyze the impact of some problem parameters on the objective function, and decision variables. Main findings Our MILP formulation is capable to optimally solve different type of instances in competitive CPU times. The battery capacity and a time limit constraint have and important impact on the objective function and the decision-making variables. Implications for theory and practice We model the EBCP as a MILP formulation. This model allows to optimally solve industrial scale instances. Moreover, using a sensitivity analysis, we unveil that both the battery capacity and the time limit constraint of the EB route are critical parameters.
DOI: 10.6084/m9.figshare.9899936
title: Use of client-centered virtual reality in rehabilitation after stroke: a feasibility study

description: ABSTRACT Patient-centered virtual reality (VR) programs could assist in the functional recovery of people after a stroke. Objectives: To analyze the feasibility of a rehabilitation protocol using client-centered VR and to evaluate changes in occupational performance and social participation. Methods: This was a mixed methods study. Ten subacute and chronic stroke patients participated in the rehabilitation program using games in non-immersive VR for 40 minutes/day, three days/week, for 12 weeks. Sociodemographic information was collected and the outcome variables included were the Canadian Occupational Performance Measure (COPM) and the Participation Scale. A field diary was used to record the frequency of attendance and adherence of participants and an interview was conducted at the end of program. Results: There were significant and clinically-relevant statistical improvements in the COPM performance score (p &lt; 0.001; CI = 1.29 − 4.858) and in the COPM satisfaction score (p &lt; 0.001; CI = 1.37 − 5.124), with a difference greater than 4.28 points for performance and 4.58 points for satisfaction. The change in the scores for participation was statistically significant (p = 0.046), but there was no clinical improvement (dcohen = −0.596, CI = −1.862 − 0.671). The majority of participants reported more than 75% consecutive attendance of sessions and there was 100% adherence to the program. In the interviews, the participants described their post-stroke difficulties; how the video game motivated their engagement in rehabilitation; and the improvement of occupational performance and social participation after participating in the program. Conclusions: VR is a viable tool for the rehabilitation of stroke patients with functional gains, mainly regarding occupational performance and performance satisfaction.