cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.30621374.v1
title: Change-Point Detection in Time Series Using Mixed Integer Programming*

description: We use cutting-edge mixed integer optimization (MIO) methods to develop a framework for detection and estimation of structural breaks in time series regression models. The framework is constructed based on the least squares problem subject to a penalty on the number of breakpoints. We restate the l0-penalized regression problem as a quadratic programming problem with integer- and real-valued arguments and show that MIO is capable of finding provably optimal solutions using a well-known optimization solver. Compared to the popular l1-penalized regression (LASSO) and other classical methods, the MIO framework permits simultaneous estimation of the number and location of structural breaks as well as regression coefficients, while accommodating the option of specifying a given or minimal number of breaks. We derive the asymptotic properties of the estimator and demonstrate its effectiveness through extensive numerical experiments, confirming a more accurate estimation of multiple breaks as compared to popular non-MIO alternatives. Two empirical examples demonstrate usefulness of the framework in applications from business and economic statistics.
DOI: 10.6084/m9.figshare.29108118
title: Exploring mechanisms of behavior change for healthcare professionals in cough and secretion management in ALS

description: To explore healthcare professionals’ experiences managing cough and secretion problems in Amyotrophic Lateral Sclerosis (ALS). A qualitative study was completed with 23 individuals participating in four focus groups. Data was analyzed using reflexive thematic analysis and COM-B and theoretical domains framework (TDF) behavior change frameworks. This study found that roles, responsibilities, and expectations needed to be clearly defined and that building relationships was important to support care delivery. Barriers identified included limited access to specialist care, equipment, and opportunities to gain knowledge and skills. A structured clinical assessment was highlighted to enable good-quality care. Data mapped most commonly to the environmental context/resources, knowledge, skills (TDF), and physical capability (COM-B) behavior change domains. Cough and secretion management in ALS is complex due to the multifaceted nature of the disease. This study emphasizes the need for future development of clinical interventions to support care. People living with Amyotrophic Lateral Sclerosis (ALS) frequently have issues with breathing, swallowing, drooling, and cough weakness. There is limited existing knowledge to tell healthcare professionals how to manage these problems and to date there is no research looking at healthcare professionals’ experiences managing these. This study aimed to understand how healthcare professionals in the UK manage cough and secretion problems in people with ALS, what challenges they face and how care can be improved. Four focus groups were completed with 23 healthcare staff. The study found that the roles and responsibilities of healthcare staff needed to be clearly defined and that building relationships was important to support care. Several barriers were identified such as limited access to specialist care, equipment, and opportunities to gain knowledge and skills. Understanding the key problems was noted to be key to providing the right cough and secretion management for people with ALS. We concluded that managing these issues in ALS is complicated as the disease is variable. To provide the best care to people living with ALS we need to develop new tools to support healthcare staff to make decisions around treatment.
DOI: 10.6084/m9.figshare.29108118.v1
title: Exploring mechanisms of behavior change for healthcare professionals in cough and secretion management in ALS

description: To explore healthcare professionals’ experiences managing cough and secretion problems in Amyotrophic Lateral Sclerosis (ALS). A qualitative study was completed with 23 individuals participating in four focus groups. Data was analyzed using reflexive thematic analysis and COM-B and theoretical domains framework (TDF) behavior change frameworks. This study found that roles, responsibilities, and expectations needed to be clearly defined and that building relationships was important to support care delivery. Barriers identified included limited access to specialist care, equipment, and opportunities to gain knowledge and skills. A structured clinical assessment was highlighted to enable good-quality care. Data mapped most commonly to the environmental context/resources, knowledge, skills (TDF), and physical capability (COM-B) behavior change domains. Cough and secretion management in ALS is complex due to the multifaceted nature of the disease. This study emphasizes the need for future development of clinical interventions to support care. People living with Amyotrophic Lateral Sclerosis (ALS) frequently have issues with breathing, swallowing, drooling, and cough weakness. There is limited existing knowledge to tell healthcare professionals how to manage these problems and to date there is no research looking at healthcare professionals’ experiences managing these. This study aimed to understand how healthcare professionals in the UK manage cough and secretion problems in people with ALS, what challenges they face and how care can be improved. Four focus groups were completed with 23 healthcare staff. The study found that the roles and responsibilities of healthcare staff needed to be clearly defined and that building relationships was important to support care. Several barriers were identified such as limited access to specialist care, equipment, and opportunities to gain knowledge and skills. Understanding the key problems was noted to be key to providing the right cough and secretion management for people with ALS. We concluded that managing these issues in ALS is complicated as the disease is variable. To provide the best care to people living with ALS we need to develop new tools to support healthcare staff to make decisions around treatment.
DOI: 10.6084/m9.figshare.30621380
title: A plain language summary on taking medication as prescribed for multiple sclerosis: impact on relapses, disability, and healthcare costs

description: <b>What is this summary about?</b> People with multiple sclerosis (MS) may struggle to take their medication as prescribed (treatment adherence), which might impact long-term disease outcomes and healthcare costs. To understand more about the relationship between treatment adherence and disease/cost outcomes, the researchers evaluated insurance <b>claims</b> in the United States from more than 8000 adults with MS between 2011 and 2017. <b>How was the analysis carried out?</b> In this analysis, researchers compared MS disease relapse rates and indicators of disability such as the use of canes, walkers, or wheelchairs as well as healthcare costs among people who took their medication as prescribed (were adherent) and those who did not (were non-adherent). <b>What were the results?</b> People with MS who were non-adherent to their prescribed medication had higher relapse rates and shorter times to first relapse, cane or walker use, and wheelchair use compared with people who were adherent to their medication. Also, people who were non-adherent had higher overall healthcare costs than those who were adherent. <b>What do the results mean?</b> These findings suggest that non-adherence to treatment prescribed for MS increases the risk of relapse, need for cane, walker, or wheelchair use, and healthcare costs.
DOI: 10.6084/m9.figshare.30621380.v1
title: A plain language summary on taking medication as prescribed for multiple sclerosis: impact on relapses, disability, and healthcare costs

description: <b>What is this summary about?</b> People with multiple sclerosis (MS) may struggle to take their medication as prescribed (treatment adherence), which might impact long-term disease outcomes and healthcare costs. To understand more about the relationship between treatment adherence and disease/cost outcomes, the researchers evaluated insurance <b>claims</b> in the United States from more than 8000 adults with MS between 2011 and 2017. <b>How was the analysis carried out?</b> In this analysis, researchers compared MS disease relapse rates and indicators of disability such as the use of canes, walkers, or wheelchairs as well as healthcare costs among people who took their medication as prescribed (were adherent) and those who did not (were non-adherent). <b>What were the results?</b> People with MS who were non-adherent to their prescribed medication had higher relapse rates and shorter times to first relapse, cane or walker use, and wheelchair use compared with people who were adherent to their medication. Also, people who were non-adherent had higher overall healthcare costs than those who were adherent. <b>What do the results mean?</b> These findings suggest that non-adherence to treatment prescribed for MS increases the risk of relapse, need for cane, walker, or wheelchair use, and healthcare costs.
DOI: 10.6084/m9.figshare.30287241
title: Pharmacokinetics, pharmacodynamics, and safety of HE009, a novel selective S1P1 receptor modulator, in healthy Chinese subjects

description: HE009, a novel selective sphingosine-1-phosphate receptor-1 (S1P1) modulator, was evaluated in healthy Chinese subjects to assess its pharmacokinetics, pharmacodynamics, and safety profile. This randomized, placebo-controlled phase I study comprised single ascending dose (SAD, 0.05–4.0 mg), multiple ascending dose (MAD, 0.5–3.0 mg), dose titration, and food effect components. HE009 exhibited dose-proportional exposure, with T<sub>max</sub>of 4–6 h and t<sub>1/2</sub> of 16–24 h, supporting once-daily dosing. Steady-state was achieved by day 7 with minimal accumulation (1.7–2.0 fold). A clear concentration-effect relationship was observed, with maximum lymphocyte count reductions of 58% (SAD) and 70–80% (MAD). Notably, HE009 demonstrated a favorable cardiac safety profile, with transient, asymptomatic bradycardia mitigated by dose titration. No events related to hypertension were observed during the study period. These findings suggest HE009 offers potential advantages in efficacy, safety, and dosing flexibility compared to existing S1P receptor modulators for treating autoimmune disorders like systemic lupus erythematosus. The trial was registered on the Chinese Clinical Trial Registry, (Identifier No. ChiCTR2200066345), Registered December 1, 2022.
DOI: 10.6084/m9.figshare.30287241.v2
title: Pharmacokinetics, pharmacodynamics, and safety of HE009, a novel selective S1P1 receptor modulator, in healthy Chinese subjects

description: HE009, a novel selective sphingosine-1-phosphate receptor-1 (S1P1) modulator, was evaluated in healthy Chinese subjects to assess its pharmacokinetics, pharmacodynamics, and safety profile. This randomized, placebo-controlled phase I study comprised single ascending dose (SAD, 0.05–4.0 mg), multiple ascending dose (MAD, 0.5–3.0 mg), dose titration, and food effect components. HE009 exhibited dose-proportional exposure, with T<sub>max</sub>of 4–6 h and t<sub>1/2</sub> of 16–24 h, supporting once-daily dosing. Steady-state was achieved by day 7 with minimal accumulation (1.7–2.0 fold). A clear concentration-effect relationship was observed, with maximum lymphocyte count reductions of 58% (SAD) and 70–80% (MAD). Notably, HE009 demonstrated a favorable cardiac safety profile, with transient, asymptomatic bradycardia mitigated by dose titration. No events related to hypertension were observed during the study period. These findings suggest HE009 offers potential advantages in efficacy, safety, and dosing flexibility compared to existing S1P receptor modulators for treating autoimmune disorders like systemic lupus erythematosus. The trial was registered on the Chinese Clinical Trial Registry, (Identifier No. ChiCTR2200066345), Registered December 1, 2022.
DOI: 10.6084/m9.figshare.30287241.v1
title: Pharmacokinetics, pharmacodynamics, and safety of HE009, a novel selective S1P1 receptor modulator, in healthy Chinese subjects

description: HE009,a novel selective sphingosine-1-phosphate receptor-1(S1P1) modulator, was evaluated in healthy Chinese subjects to assess itspharmacokinetics, pharmacodynamics, and safety profile. This randomized, placebo-controlled phase I studycomprised single ascending dose (SAD, 0.05-4.0 mg), multiple ascending dose(MAD, 0.5-3.0 mg), dose titration, and food effect components. HE009 exhibited dose-proportional exposure, with T<sub>max</sub>of 4-6 hours and t<sub>1/2</sub> of 16-24 hours, supporting once-daily dosing.Steady-state was achieved by day 7 with minimal accumulation (1.7-2.0 fold). Aclear concentration-effect relationship was observed, with maximum lymphocytecount reductions of 58% (SAD) and 70-80% (MAD). Notably, HE009 demonstrated afavorable cardiac safety profile, with transient, asymptomatic bradycardiamitigated by dose titration. No events related to hypertension were observedduring the study period. Thesefindings suggest HE009 offers potential advantages in efficacy, safety, anddosing flexibility compared to existing S1P receptor modulators for treatingautoimmune disorders like systemic lupus erythematosus. The trial was registered on the ChineseClinical Trial Registry, (Identifier No. ChiCTR2200066345), Registered December1, 2022.
DOI: 10.15468/dl.j5vrwz
title: Occurrence Download

description: A dataset containing 24 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Lissotriton kosswigi"
 ]
}

 The dataset includes 24 records from 8 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0033637-251025141854904/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.c3yay8
title: Occurrence Download

description: A dataset containing 566 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Continent is North America",
 "Country is United States of America",
 "Geometry POLYGON((-69.22138 47.38187,-70.63208 45.50276,-72.98325 44.87309,-70.58506 43.59284,-67.10532 45.10588,-67.8577 46.86997,-69.22138 47.38187))",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 "TaxonKey is Ursus americanus"
 ]
}

 The dataset includes 566 records from 12 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0033638-251025141854904/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.cc2tmh
title: Occurrence Download

description: A dataset containing 394 species occurrences available in GBIF matching the query:
{
 "and" : [
 "BasisOfRecord is one of (Material sample, Specimen)",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "TaxonKey is Hylarana nigrovittata"
 ]
}

 The dataset includes 394 records from 4 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0033640-251025141854904/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.74qjkz
title: Occurrence Download

description: A dataset containing 2862 species occurrences available in GBIF matching the query:
{
 "DatasetKey" : [
 "is Forest bats in Peninsular Malaysia_2007-2009"
 ]
}

 The dataset includes 2862 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0033641-251025141854904/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.6bcvck
title: Occurrence Download

description: A dataset containing 146475 species occurrences available in GBIF matching the query:
{
 "DatasetKey" : [
 "is Butterfly monitoring scheme in Flanders, Belgium"
 ]
}

 The dataset includes 146475 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0033624-251025141854904/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.yvh24u
title: Occurrence Download

description: A dataset containing 210685 species occurrences available in GBIF matching the query:
{
 "DatasetKey" : [
 "is ABV - Common breeding birds in Flanders, Belgium (post 2016)"
 ]
}

 The dataset includes 210685 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0033625-251025141854904/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.hezq5q
title: Occurrence Download

description: A dataset containing 1697 species occurrences available in GBIF matching the query:
{
 "DatasetKey" : [
 "is Meetnetten.be - Exuviae counts for dragonflies in Flanders, Belgium"
 ]
}

 The dataset includes 1697 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0033639-251025141854904/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.17605/osf.io/zxpbn
title: Machine-Readable Table from Richard et al. (2003) "One hundred years of social psychology quantitatively described"

description: A machine-readable table from Appendix B, Richard et al. (2003) - Richard, F. D., Bond, C. F., & Stokes-zoota, J. J. (2003). One hundred years of social psychology quantitatively described. Review of General Psychology, 331–363.
DOI: 10.15468/dl.zfub4t
title: Occurrence Download

description: A dataset containing 126 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Handroanthus lapacho"
 ]
}

 The dataset includes 126 records from 29 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0033643-251025141854904/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.57745/wgqhfn
title: DRYvER_WP2_Macroinvertebrate_raw_data_v0.6.tab

description: :unav
DOI: 10.57745/7cdgbx
title: DRYvER_WP2_Macroinvertebrate_raw_data_04SampleData_v0.6.txt

description: Macroinvertebrate taxalist per sample
DOI: 10.57745/euosi7
title: DRYvER_WP2_Macroinvertebrate_raw_data_03Sample_v0.6.txt

description: Sample informations from one given survey (eg. one surber net sampling)
DOI: 10.57745/v3s2o0
title: DRYvER_WP2_Macroinvertebrate_raw_data_02Survey_v0.6.txt

description: survey information (one survey = one date, one place, one sampling protocol)
DOI: 10.57745/kjdobo
title: DRYvER_WP2_Macroinvertebrate_simplified data diagram.png

description: simplified data diagram
DOI: 10.57745/vbajqw
title: DRYvER_WP2_Macroinvertebrate_raw_data_01Site_v0.6.txt

description: sampling sites information
DOI: 10.57745/hk4ymh
title: DRYvER_WP2_Macroinvertebrate_EU_data.tab

description: :unav
DOI: 10.57745/rv2iur
title: DRYvER_WP2_Macroinvertebrate_EU_DB Schema.jpg

description: :unav
DOI: 10.57745/dz8neb
title: DRYvER_WP2_Macroinvertebrate_EU_Data Dictionary.tab

description: :unav
DOI: 10.57745/otlww9
title: DRYvER_WP2_Macroinvertebrate_simplified data diagram.jpg

description: simplified data diagram
DOI: 10.57745/ckxvrf
title: DRYvER_WP2_Macroinvertebrate_EU_data.tab

description: :unav
DOI: 10.57745/iczr01
title: DRYvER_WP2_Macroinvertebrate_simplified data diagram.jpg

description: simplified data diagram
DOI: 10.57745/qcrm7j
title: DRYvER_WP2_Macroinvertebrate_EU_DB Schema.jpg

description: :unav
DOI: 10.57745/phevxv
title: DRYvER_WP2_Macroinvertebrate_EU_data.tab

description: :unav
DOI: 10.15468/dl.5sjk88
title: Occurrence Download

description: A dataset containing 2848 species occurrences available in GBIF matching the query:
{
 "DatasetKey" : [
 "is Meetnetten.be - Larvae and metamorph counts for Amphibia in Flanders, Belgium"
 ]
}

 The dataset includes 2848 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0033646-251025141854904/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.xv4x8e
title: Occurrence Download

description: A dataset containing 2374 species occurrences available in GBIF matching the query:
{
 "DatasetKey" : [
 "is Meetnetten.be - Occupancy estimates of priority vascular plants species in Flanders, Belgium"
 ]
}

 The dataset includes 2374 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0033647-251025141854904/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.me6tvq
title: Occurrence Download

description: A dataset containing 8810 species occurrences available in GBIF matching the query:
{
 "DatasetKey" : [
 "is Meetnetten.be - Fyke counts for Amphibia in Flanders, Belgium"
 ]
}

 The dataset includes 8810 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0033645-251025141854904/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.7bzzm3
title: Occurrence Download

description: A dataset containing 12 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is Iran (Islamic Republic of)",
 "TaxonKey is Cichorium pumilum"
 ]
}

 The dataset includes 12 records from 4 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0033649-251025141854904/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.6084/m9.figshare.25062014
title: Data from: Herbivory and vegetation openness in a pre-farming European landscape

description: Sediment properties and palaeoecological data from investigations at the Well-Aijen archaeological site (Limburg, the Netherlands).For further details see the associated publication:Published in: Plant Ecology & Diversity<br>Title: Herbivory and vegetation openness in a pre-farming European landscapeAuthors: William D. Gosling, Iris K. de Wolf, Nina H. Witteveen, Suzanne B. de Zwaan, Corné van Teulingen, Dante Föllmi, Waas Thissen, Veerle B. Vink, Amber Woutersen, Annemarie L. Philip, Maria van Herk, Majoi N. Nascimento, Maarten A. Prins, Crystal N.H. McMichaelDOI: https://doi.org/10.1080/17550874.2025.2576566
DOI: 10.6084/m9.figshare.25062014.v1
title: Data from: Herbivory and vegetation openness in a pre-farming European landscape

description: Sediment properties and palaeoecological data from investigations at the Well-Aijen archaeological site (Limburg, the Netherlands).For further details see the associated publication:Published in: Plant Ecology & Diversity<br>Title: Herbivory and vegetation openness in a pre-farming European landscapeAuthors: William D. Gosling, Iris K. de Wolf, Nina H. Witteveen, Suzanne B. de Zwaan, Corné van Teulingen, Dante Föllmi, Waas Thissen, Veerle B. Vink, Amber Woutersen, Annemarie L. Philip, Maria van Herk, Majoi N. Nascimento, Maarten A. Prins, Crystal N.H. McMichaelDOI: https://doi.org/10.1080/17550874.2025.2576566
DOI: 10.15468/dl.f5xfhu
title: Occurrence Download

description: A dataset listing the 119 species recorded in GBIF matching the query:
{
 "and" : [
 "GadmGid is COL.4_2",
 "OccurrenceStatus is Present",
 "TaxonKey is one of (Squamata, Crocodylia, Testudines)"
 ]
}

 The dataset's 119 records were derived from 25 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0033629-251025141854904/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.