cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.5281/zenodo.7491596
title: Raw data of the publication: Does moderate hyperkalemia influence survival in HF? Insights from the MECKI score data (Int J Cardiol . 2023 Jan 15;371:273-277. doi: 10.1016/j.ijcard.2022.09.030. Epub 2022 Sep 15)

description: <strong>Background: </strong>The prognostic role of moderate hyperkalemia in reduced ejection fraction (HFrEF) patients is still controversial. Despite this, it affects the use of renin-angiotensin-aldosterone system inhibitors (RAASi) with therapy down-titration or discontinuation. <strong>Objectives: </strong>Aim of the study was to assess the prognostic impact of moderate hyperkalemia in chronic HFrEF optimally treated patients. <strong>Methods and results: </strong>We retrospectively analyzed MECKI (Metabolic Exercise test data combined with Cardiac and Kidney Indexes) database, with median follow-up of 4.2 [IQR 1.9-7.5] years. Data on K<sup>+</sup> levels were available in 7087 cases. Patients with K<sup>+</sup> plasma level ≥ 5.6 mEq/L and &lt; 4 mEq/L were excluded. Remaining patients were categorized into normal &gt;4 and &lt; 5 mEq/L (n = 4826, 68%) and moderately high ≥5.0 and ≤ 5.5 mEq/L (n = 496, 7%) K<sup>+</sup>. Then patients were matched by propensity score in 484 couplets of patients. MECKI score value was 7% [IQR 3.1-14.1%] and 7.3% [IQR 3.4-15%] (p = 0.678) in patients with normal and moderately high K<sup>+</sup> values while cardiovascular mortality events at two years follow-up were 41 (4.2%) and 33 (3.4%) (p = 0.333) in each group respectively. <strong>Conclusions: </strong>Moderate hyperkalemia does not influence patients' outcome in a large cohort of ambulatory HFrEF patients.
DOI: 10.6084/m9.figshare.21805410
title: SI - Solvatochromic sensitivity of BODIPY probes.zip

description: files SI.csv, SI.sdf, SI.docx, SI_FigS4-A-Em_vs_Abs, SI_FigS4-A-Em_vs_Solvent, SI_FigS4-B-Em_vs_Abs, SI_FigS4-B-Em_vs_Solvent, SI_FigS4-C-Em_vs_Abs, SI_FigS4-C-Em_vs_Solvent, SI_FigS4-D-Em_vs_Abs, SI_FigS4-D-Em_vs_Solvent. Additional htm-files: SI_Figure2–SI_Figure10 are corresponding to figures in the text of the paper with tooltip text characterising the compound ID, solvent name, solvatochromic sensitivity, relation E/C, Absorption maxima, Emission maxima, Stokes shift, and Quantum yield.
DOI: 10.6084/m9.figshare.21805410.v1
title: SI - Solvatochromic sensitivity of BODIPY probes.zip

description: files SI.csv, SI.sdf, SI.docx, SI_FigS4-A-Em_vs_Abs, SI_FigS4-A-Em_vs_Solvent, SI_FigS4-B-Em_vs_Abs, SI_FigS4-B-Em_vs_Solvent, SI_FigS4-C-Em_vs_Abs, SI_FigS4-C-Em_vs_Solvent, SI_FigS4-D-Em_vs_Abs, SI_FigS4-D-Em_vs_Solvent. Additional htm-files: SI_Figure2–SI_Figure10 are corresponding to figures in the text of the paper with tooltip text characterising the compound ID, solvent name, solvatochromic sensitivity, relation E/C, Absorption maxima, Emission maxima, Stokes shift, and Quantum yield.
DOI: 10.5281/zenodo.7489414
title: Dtaset related to the article The double anaerobic threshold in heart failure: MECKI score database overview. ESC Heart Fail. 2022;9:2119-2124.

description: <strong>Aims: </strong>In heart failure (HF), anaerobic threshold (AT) may be indeterminable but its value held a relevant prognostic role. AT is evaluated joining three methods: V-slope, ventilatory equivalent, and end-tidal methods. The possible non-concordance between the V-slope (met AT) and the other two methods (vent AT) has been highlighted in healthy individuals and named double threshold (DT). <strong>Methods and results: </strong>We reanalysed 1075 cardiopulmonary exercise tests of HF patients recruited in the Metabolic Exercise test data combined with Cardiac and Kidney Indexes (MECKI) score database. We identified DT in 43% of cases. Met AT precedes vent AT being met-ventΔVO<sub>2</sub> 221 (interquartile range: 129-319) mL/min. Peak VO<sub>2</sub> , 1307 ± 485 vs. 1343 ± 446 mL/min (63 ± 17 vs. 63 ± 17 percentage of predicted), was similar between DT+ and DT- patients. Differently, DT+ showed a lower ventilatory vs. carbon dioxide production (VE/VCO<sub>2</sub> ) slope (29.6 ± 6.1 vs. 31.0 ± 6.3), a lower peak exercise end-tidal oxygen tension (PetO<sub>2</sub> ) 115.3 (111.5-118.9) vs. 116.4 (112.4-120.2) mmHg, and a higher carbon dioxide tension (PetCO<sub>2</sub> ) 34.2 (30.9-37.1) vs. 32.4 (28.7-35.5) mmHg. Vent AT showed a significant higher VO<sub>2</sub> , 957 ± 318 vs. 719 ± 252 mL/min, VCO<sub>2</sub> , 939 ± 319 vs. 627 ± 226 mL/min, ventilation, 31.0 ± 8.3 vs. 22.5 ± 6.3 L/min, respiratory exchange ratio, 0.98 ± 0.08 vs. 0.87 ± 0.07, PetO<sub>2</sub> , 108 (104-112) vs. 105 (101-109) mmHg, PetCO<sub>2</sub> , 37 (34-40) vs. 36 (33-39) mmHg, and VE/VO<sub>2</sub> ratio, 33.5 ± 6.7 vs. 32.6 ± 6.9, but lower VE/VCO<sub>2</sub> ratio, 33 (30-37) vs. 36 (32-41), compared with met AT. At 2 year survival by Kaplan-Meier analysis, even adjusted for confounders, DT resulted not associated with survival. <strong>Conclusions: </strong>Double threshold is frequently observed in HF patients. DT+ is associated to a decreased ventilatory response during exercise.
DOI: 10.5281/zenodo.7489415
title: Dtaset related to the article The double anaerobic threshold in heart failure: MECKI score database overview. ESC Heart Fail. 2022;9:2119-2124.

description: <strong>Aims: </strong>In heart failure (HF), anaerobic threshold (AT) may be indeterminable but its value held a relevant prognostic role. AT is evaluated joining three methods: V-slope, ventilatory equivalent, and end-tidal methods. The possible non-concordance between the V-slope (met AT) and the other two methods (vent AT) has been highlighted in healthy individuals and named double threshold (DT). <strong>Methods and results: </strong>We reanalysed 1075 cardiopulmonary exercise tests of HF patients recruited in the Metabolic Exercise test data combined with Cardiac and Kidney Indexes (MECKI) score database. We identified DT in 43% of cases. Met AT precedes vent AT being met-ventΔVO<sub>2</sub> 221 (interquartile range: 129-319) mL/min. Peak VO<sub>2</sub> , 1307 ± 485 vs. 1343 ± 446 mL/min (63 ± 17 vs. 63 ± 17 percentage of predicted), was similar between DT+ and DT- patients. Differently, DT+ showed a lower ventilatory vs. carbon dioxide production (VE/VCO<sub>2</sub> ) slope (29.6 ± 6.1 vs. 31.0 ± 6.3), a lower peak exercise end-tidal oxygen tension (PetO<sub>2</sub> ) 115.3 (111.5-118.9) vs. 116.4 (112.4-120.2) mmHg, and a higher carbon dioxide tension (PetCO<sub>2</sub> ) 34.2 (30.9-37.1) vs. 32.4 (28.7-35.5) mmHg. Vent AT showed a significant higher VO<sub>2</sub> , 957 ± 318 vs. 719 ± 252 mL/min, VCO<sub>2</sub> , 939 ± 319 vs. 627 ± 226 mL/min, ventilation, 31.0 ± 8.3 vs. 22.5 ± 6.3 L/min, respiratory exchange ratio, 0.98 ± 0.08 vs. 0.87 ± 0.07, PetO<sub>2</sub> , 108 (104-112) vs. 105 (101-109) mmHg, PetCO<sub>2</sub> , 37 (34-40) vs. 36 (33-39) mmHg, and VE/VO<sub>2</sub> ratio, 33.5 ± 6.7 vs. 32.6 ± 6.9, but lower VE/VCO<sub>2</sub> ratio, 33 (30-37) vs. 36 (32-41), compared with met AT. At 2 year survival by Kaplan-Meier analysis, even adjusted for confounders, DT resulted not associated with survival. <strong>Conclusions: </strong>Double threshold is frequently observed in HF patients. DT+ is associated to a decreased ventilatory response during exercise.
DOI: 10.5281/zenodo.7489354
title: Dataset related to the article Mapelli M, Zagni P, Ferrara R, Calbi V, Mattavelli I, Muratori M, et al. Unexpected Huge Prevalence of Intracardiac Extension of Wilms Tumor-A Single Center Experience from a Ugandan Hospital. Children (Basel). 2022;9.

description: Wilms tumor (WT) is the most common primary renal malignancy in young children. WT vascular extension to the inferior vena cava (IVC) occurs in 4–10% of cases and can reach the right atrium (RA) in 1%. Data on WT clinical presentation and outcome in developing countries are limited. The aim of the present study is to describe the prevalence of intracardiac extension in a consecutive population of WT patients observed in a large non-profit Ugandan hospital. A total of 16 patients with a histological diagnosis of 29 WT were screened in a 6-month period. Patient n°2, a 3 y/o child, presented with a 3-week history of abdominal distension, difficulty in breathing, and swelling of the lower limbs. A cardiovascular system exam showed rhythmic heart sounds, a heart rate of 110 beats per minute, and a pansystolic murmur on the tricuspid area; the abdomen was grossly distended with a palpable mass in the right flank, hepatomegaly, and splenomegaly. An abdomen ultrasound showed an intra-abdominal tumor, involving the right kidney and the liver and extended to the IVC. An ultrasound guided biopsy showed a picture consistent with WT. Cardiac echo showed a huge, mobile, cardiac mass attached to the right side of the interatrial septum, involving the tricuspid valve annulus, causing a “functional” tricuspid stenosis. The patient died of cardiogenic shock 7 days after admission. Patient n°3, a 3 y/o child, presented with analogue symptoms and the same diagnosis. The cardiac echo showed a round mass in the RA. Thirteen more patients were screened with cardiac echo, showing a normal heart picture. In our limited series, we found WT cardiac extension in three patients over 16 (19%). Cardiac echo performed routinely can lead to a better staging, prognostic, and therapeutic assessment. In our setting, the intra-cardiac extension could be more frequent than previously reported and might have prognostic implications.
DOI: 10.5281/zenodo.7489355
title: Dataset related to the article Mapelli M, Zagni P, Ferrara R, Calbi V, Mattavelli I, Muratori M, et al. Unexpected Huge Prevalence of Intracardiac Extension of Wilms Tumor-A Single Center Experience from a Ugandan Hospital. Children (Basel). 2022;9.

description: Wilms tumor (WT) is the most common primary renal malignancy in young children. WT vascular extension to the inferior vena cava (IVC) occurs in 4–10% of cases and can reach the right atrium (RA) in 1%. Data on WT clinical presentation and outcome in developing countries are limited. The aim of the present study is to describe the prevalence of intracardiac extension in a consecutive population of WT patients observed in a large non-profit Ugandan hospital. A total of 16 patients with a histological diagnosis of 29 WT were screened in a 6-month period. Patient n°2, a 3 y/o child, presented with a 3-week history of abdominal distension, difficulty in breathing, and swelling of the lower limbs. A cardiovascular system exam showed rhythmic heart sounds, a heart rate of 110 beats per minute, and a pansystolic murmur on the tricuspid area; the abdomen was grossly distended with a palpable mass in the right flank, hepatomegaly, and splenomegaly. An abdomen ultrasound showed an intra-abdominal tumor, involving the right kidney and the liver and extended to the IVC. An ultrasound guided biopsy showed a picture consistent with WT. Cardiac echo showed a huge, mobile, cardiac mass attached to the right side of the interatrial septum, involving the tricuspid valve annulus, causing a “functional” tricuspid stenosis. The patient died of cardiogenic shock 7 days after admission. Patient n°3, a 3 y/o child, presented with analogue symptoms and the same diagnosis. The cardiac echo showed a round mass in the RA. Thirteen more patients were screened with cardiac echo, showing a normal heart picture. In our limited series, we found WT cardiac extension in three patients over 16 (19%). Cardiac echo performed routinely can lead to a better staging, prognostic, and therapeutic assessment. In our setting, the intra-cardiac extension could be more frequent than previously reported and might have prognostic implications.
DOI: 10.5517/ccdc.csd.cc2ckwvp
title: CCDC 2191943: Experimental Crystal Structure Determination

description: Related Article: Zhenxing Yu, Guangjin Shi, Kun-Peng Wang, Liang-Zhong Xu, Shaojin Chen, Zhi-Qiang Hu|2022|Tetrahedron|130|133178|doi:10.1016/j.tet.2022.133178
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2czbk8
title: CCDC 2203900: Experimental Crystal Structure Determination

description: Related Article: Xiao-Fang Song, Li-Jing Zhang, Xing-Guo Zhang, Hai-Yong Tu|2022|Tetrahedron|130|133166|doi:10.1016/j.tet.2022.133166
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2d9z2s
title: CCDC 2214115: Experimental Crystal Structure Determination

description: Related Article: Fei Li, Hui-Min Li, Ren-Feng Xiu, Jin-Ke Zhang, Bao-Dong Cui, Nan-Wei Wan, Yong-Zheng Chen, Wen-Yong Han|2022|Org.Lett.|24|9392|doi:10.1021/acs.orglett.2c03713
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2d9z3t
title: CCDC 2214116: Experimental Crystal Structure Determination

description: Related Article: Fei Li, Hui-Min Li, Ren-Feng Xiu, Jin-Ke Zhang, Bao-Dong Cui, Nan-Wei Wan, Yong-Zheng Chen, Wen-Yong Han|2022|Org.Lett.|24|9392|doi:10.1021/acs.orglett.2c03713
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2d9z4v
title: CCDC 2214117: Experimental Crystal Structure Determination

description: Related Article: Fei Li, Hui-Min Li, Ren-Feng Xiu, Jin-Ke Zhang, Bao-Dong Cui, Nan-Wei Wan, Yong-Zheng Chen, Wen-Yong Han|2022|Org.Lett.|24|9392|doi:10.1021/acs.orglett.2c03713
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2d9z5w
title: CCDC 2214118: Experimental Crystal Structure Determination

description: Related Article: Fei Li, Hui-Min Li, Ren-Feng Xiu, Jin-Ke Zhang, Bao-Dong Cui, Nan-Wei Wan, Yong-Zheng Chen, Wen-Yong Han|2022|Org.Lett.|24|9392|doi:10.1021/acs.orglett.2c03713
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2d9z6x
title: CCDC 2214119: Experimental Crystal Structure Determination

description: Related Article: Fei Li, Hui-Min Li, Ren-Feng Xiu, Jin-Ke Zhang, Bao-Dong Cui, Nan-Wei Wan, Yong-Zheng Chen, Wen-Yong Han|2022|Org.Lett.|24|9392|doi:10.1021/acs.orglett.2c03713
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5281/zenodo.7488605
title: Dataset related to the publication Rovai S, Contini M, Sciomer S, Vignati C, Agostoni P. The double anaerobic threshold in heart failure. Int J Cardiol. 2022;353:68-70.

description: <strong>Background: </strong>Cardiopulmonary exercise test (CPET) has an important role in assessing heart failure (HF) patients. Among CPET parameters, a pivotal role is attributed to the anaerobic threshold (AT), normally determined by V-slope, ventilatory equivalent and end-tidal methods. In about 10% of healthy subjects, a lack of concordance between these methods has been reported. This event was named double AT (DT). We hypothesized that DT was due to a delay in chemoreflex response. <strong>Methods: </strong>We reanalyzed CPET data of two cross-over studies in which we compared CPET in stable HF patients treated for two months with bisoprolol and carvedilol. In chronic HF, carvedilol has a greater sympathetic inhibition than bisoprolol, as shown by a lower chemoreflex response. <strong>Results: </strong>In 87 patients, we identified DT in 46% and 66% of cases during bisoprolol and carvedilol treatment, respectively (p &lt; 0.01). Compared with bisoprolol, carvedilol treatment was associated to a lower peak oxygen uptake (from 17.4 ± 4.3 to 16.4 ± 4.1 mL/min/kg) and oxygen pulse (from 11.8 ± 2.9 to 11.1 ± 2.9 mL/min/kg) suggestive of lower peak cardiac output. <strong>Conclusions: </strong>DT is frequent in HF and more often with carvedilol than bisoprolol treatment, may be due to a greater inhibition of sympathetic tone and prolonged circulatory time. These findings open an unexplored research field.
DOI: 10.5281/zenodo.7488606
title: Dataset related to the publication Rovai S, Contini M, Sciomer S, Vignati C, Agostoni P. The double anaerobic threshold in heart failure. Int J Cardiol. 2022;353:68-70.

description: <strong>Background: </strong>Cardiopulmonary exercise test (CPET) has an important role in assessing heart failure (HF) patients. Among CPET parameters, a pivotal role is attributed to the anaerobic threshold (AT), normally determined by V-slope, ventilatory equivalent and end-tidal methods. In about 10% of healthy subjects, a lack of concordance between these methods has been reported. This event was named double AT (DT). We hypothesized that DT was due to a delay in chemoreflex response. <strong>Methods: </strong>We reanalyzed CPET data of two cross-over studies in which we compared CPET in stable HF patients treated for two months with bisoprolol and carvedilol. In chronic HF, carvedilol has a greater sympathetic inhibition than bisoprolol, as shown by a lower chemoreflex response. <strong>Results: </strong>In 87 patients, we identified DT in 46% and 66% of cases during bisoprolol and carvedilol treatment, respectively (p &lt; 0.01). Compared with bisoprolol, carvedilol treatment was associated to a lower peak oxygen uptake (from 17.4 ± 4.3 to 16.4 ± 4.1 mL/min/kg) and oxygen pulse (from 11.8 ± 2.9 to 11.1 ± 2.9 mL/min/kg) suggestive of lower peak cardiac output. <strong>Conclusions: </strong>DT is frequent in HF and more often with carvedilol than bisoprolol treatment, may be due to a greater inhibition of sympathetic tone and prolonged circulatory time. These findings open an unexplored research field.
DOI: 10.5281/zenodo.7488541
title: Dataset related to the publication "Mapelli M, Romani S, Magri D, Merlo M, Cittar M, Mase M, et al. Exercise oxygen pulse kinetics in patients with hypertrophic cardiomyopathy". Heart.

description: <strong>Objectives: </strong>Reduced cardiac output (CO) has been considered crucial in symptoms' genesis in hypertrophic cardiomyopathy (HCM). Absolute value and temporal behaviour of O<sub>2</sub>-pulse (oxygen uptake/heart rate (VO<sub>2</sub>/HR)), and the VO<sub>2</sub>/work relationship during exercise reflect closely stroke volume (SV) and CO changes, respectively. We hypothesise that adding O<sub>2</sub>-pulse absolute value and kinetics, and VO<sub>2</sub>/work relationship to standard cardiopulmonary exercise testing (CPET) could help identify more exercise-limited patients with HCM. <strong>Methods: </strong>CPETs were performed in 3 HCM dedicated clinical units. We retrospectively enrolled non-end-stage consecutive patients with HCM, grouped according to left ventricle outflow tract obstruction (LVOTO) at rest or during Valsalva manoeuvre (72% of patients with LVOTO &lt;30; 10% between 30 and 49 and 18% ≥50 mm Hg). We evaluated the CPET response in HCM focusing on parameters strongly associated with SV and CO, such as O<sub>2</sub>-pulse and VO<sub>2</sub>, respectively, considering their absolute values and temporal behaviour during exercise. <strong>Results: </strong>We included 312 patients (70% males, age 49±18 years). Peak VO<sub>2</sub> (percentage of predicted), O<sub>2</sub>-pulse and ventilation to carbon dioxide production (VE/VCO<sub>2</sub>) slope did not change across LVOTO groups. Ninety-six (31%) patients with HCM presented an abnormal O<sub>2</sub>-pulse temporal behaviour, irrespective of LVOTO values. These patients showed lower peak systolic pressure, workload (106±45 vs 130±49 W), VO<sub>2</sub> (21.3±6.6 vs 24.1±7.7 mL/min/kg; 74%±17% vs 80%±20%) and O<sub>2</sub>-pulse (12 (9-14) vs 14 (11-17) mL/beat), with higher VE/VCO<sub>2</sub> slope (28 (25-31) vs 27 (24-31)) (p&lt;0.005 for all). Only 2 patients had an abnormal VO<sub>2</sub>/work slope. <strong>Conclusion: </strong>None of the frequently used CPET parameters, either as absolute values or dynamic relationships, were associated with LVOTO. Differently, an abnormal temporal behaviour of O<sub>2</sub>-pulse during exercise, which is strongly related to inadequate SV increase, correlates with reduced functional capacity (peak and anaerobic threshold VO<sub>2</sub> and workload) and increased VE/VCO<sub>2</sub> slope, identifying more advanced disease irrespectively of LVOTO.