cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.24271228
title: Supplementary Material for: Two distinct characteristics of immune microenvironment in human hepatocellular carcinoma with Wnt/β-catenin mutations

description: Introduction Immunotherapy is becoming a promising approach for unresectable-hepatocellular carcinoma (HCC); the anti-tumor response is affected by the tumor microenvironment (TME). Although Wnt/β-catenin mutations are reported to cause non-inflamed phenotype, their role on TME remains controversial. We aimed to clarify the heterogeneity of immunophenotype in HCC with Wnt/β-catenin mutations. Methods This study includes 152 resected HCCs; mutations in the catenin beta-1, adenomatous polyposis coli, or AXIN1, or AXIN2 genes were defined as Wnt/β-catenin mutations. With hierarchical cluster analyses, TME were classified into inflamed or non-inflamed classes based on the gene expressions associated with T-cell activation. Expression profiles of molecules related to cell differentiation and biliary-stem cell markers were compared between the TME classes to investigate whether differences in tumor traits were associated with TME. Results Forty of 152 (26.3%) HCCs carried the Wnt/β-catenin mutations. Of these, 33 were classified as non-inflamed (33/40, 82.5%) and 7 as inflamed (7/40, 17.5%). Non-inflamed class was characterized by low number of CD3+, CD4+, and CD8+ cells on immunostaining, and high mRNA expressions of AXIN2 and GLUL, which are involved in the canonical Wnt/β-catenin signaling and hepatocyte differentiation, respectively. Non-inflamed tumors showed higher enhancement on the hepatobiliary-phase of gadolinium-ethoxybenzyl-diethylenetriamine (Gd-EOB-DTPA)-enhanced magnetic resonance imaging (MRI) compared to inflamed tumors. HCCs classified as inflamed class are revealed to have high numbers of CD3+, CD4+, and CD8+ tumor infiltrating lymphocytes on immunostaining. This class is associated with increased expression of anti-epithelial cell adhesion molecule (EpCAM) and FOXM1 accompanied by upregulation of genes related to interferon-gamma signaling, dendritic cell migration, regulatory T cells and MDSC activation and recognized as low enhancement nodule on Gd-EOB-DTPA-enhanced MRI. Conclusion Heterogeneity of tumor traits and TME was observed in HCC with Wnt/β-catenin mutation. The potential was indicated that tumor traits and TME are determined not only by the activation of the HNF4A but also by FOXM1, both of which are downstream transcription factor of the Wnt/β-catenin signaling pathway.
DOI: 10.6084/m9.figshare.24271228.v1
title: Supplementary Material for: Two distinct characteristics of immune microenvironment in human hepatocellular carcinoma with Wnt/β-catenin mutations

description: Introduction Immunotherapy is becoming a promising approach for unresectable-hepatocellular carcinoma (HCC); the anti-tumor response is affected by the tumor microenvironment (TME). Although Wnt/β-catenin mutations are reported to cause non-inflamed phenotype, their role on TME remains controversial. We aimed to clarify the heterogeneity of immunophenotype in HCC with Wnt/β-catenin mutations. Methods This study includes 152 resected HCCs; mutations in the catenin beta-1, adenomatous polyposis coli, or AXIN1, or AXIN2 genes were defined as Wnt/β-catenin mutations. With hierarchical cluster analyses, TME were classified into inflamed or non-inflamed classes based on the gene expressions associated with T-cell activation. Expression profiles of molecules related to cell differentiation and biliary-stem cell markers were compared between the TME classes to investigate whether differences in tumor traits were associated with TME. Results Forty of 152 (26.3%) HCCs carried the Wnt/β-catenin mutations. Of these, 33 were classified as non-inflamed (33/40, 82.5%) and 7 as inflamed (7/40, 17.5%). Non-inflamed class was characterized by low number of CD3+, CD4+, and CD8+ cells on immunostaining, and high mRNA expressions of AXIN2 and GLUL, which are involved in the canonical Wnt/β-catenin signaling and hepatocyte differentiation, respectively. Non-inflamed tumors showed higher enhancement on the hepatobiliary-phase of gadolinium-ethoxybenzyl-diethylenetriamine (Gd-EOB-DTPA)-enhanced magnetic resonance imaging (MRI) compared to inflamed tumors. HCCs classified as inflamed class are revealed to have high numbers of CD3+, CD4+, and CD8+ tumor infiltrating lymphocytes on immunostaining. This class is associated with increased expression of anti-epithelial cell adhesion molecule (EpCAM) and FOXM1 accompanied by upregulation of genes related to interferon-gamma signaling, dendritic cell migration, regulatory T cells and MDSC activation and recognized as low enhancement nodule on Gd-EOB-DTPA-enhanced MRI. Conclusion Heterogeneity of tumor traits and TME was observed in HCC with Wnt/β-catenin mutation. The potential was indicated that tumor traits and TME are determined not only by the activation of the HNF4A but also by FOXM1, both of which are downstream transcription factor of the Wnt/β-catenin signaling pathway.
DOI: 10.6084/m9.figshare.24064473
title: Data and programs related to the article "Energy Transfer of Imbalanced Alfvénic Turbulence in the Heliosphere"

description: This data repository includes: raw and analyzed data observed from PSP spacecraft, raw data from MHD turbulence simulations as well as data from analysis diagnostics. The raw data of the simulation consists of spatial distributions of Elsässer variables at specific times. The analysis diagnostic data includes information about the propagation and lifetime of Elsässer variables, comparisons of relative magnitudes of each term in the governing equations (particularly comparing linear, nonlinear, and compressible terms), analysis results of the wave-vector dynamics of energy cascade rates, differences in energy spectral indices under different cross helicity conditions, and differences in energy cascade rates.
DOI: 10.6084/m9.figshare.24064473.v2
title: Data and programs related to the article "Energy Transfer of Imbalanced Alfvénic Turbulence in the Heliosphere"

description: This data repository includes: raw and analyzed data observed from PSP spacecraft, raw data from MHD turbulence simulations as well as data from analysis diagnostics. The raw data of the simulation consists of spatial distributions of Elsässer variables at specific times. The analysis diagnostic data includes information about the propagation and lifetime of Elsässer variables, comparisons of relative magnitudes of each term in the governing equations (particularly comparing linear, nonlinear, and compressible terms), analysis results of the wave-vector dynamics of energy cascade rates, differences in energy spectral indices under different cross helicity conditions, and differences in energy cascade rates.
DOI: 10.6084/m9.figshare.24064473.v1
title: Data and programs related to the article "Energy Transfer of Imbalanced Alfvénic Turbulence in the Heliosphere"

description: This data repository includes: raw data from MHD turbulence simulations as well as data from analysis diagnostics. The raw data consists of spatial distributions of Elsässer variables at specific times. The analysis diagnostic data includes information about the propagation and lifetime of Elsässer variables, comparisons of relative magnitudes of each term in the governing equations (particularly comparing linear, nonlinear, and compressible terms), analysis results of the wave-vector dynamics of energy cascade rates, differences in energy spectral indices under different cross helicity conditions, and differences in energy cascade rates.
DOI: 10.6084/m9.figshare.24271237
title: Supplementary Material for: Two distinct characteristics of immune microenvironment in human hepatocellular carcinoma with Wnt/β-catenin mutations

description: Introduction Immunotherapy is becoming a promising approach for unresectable-hepatocellular carcinoma (HCC); the anti-tumor response is affected by the tumor microenvironment (TME). Although Wnt/β-catenin mutations are reported to cause non-inflamed phenotype, their role on TME remains controversial. We aimed to clarify the heterogeneity of immunophenotype in HCC with Wnt/β-catenin mutations. Methods This study includes 152 resected HCCs; mutations in the catenin beta-1, adenomatous polyposis coli, or AXIN1, or AXIN2 genes were defined as Wnt/β-catenin mutations. With hierarchical cluster analyses, TME were classified into inflamed or non-inflamed classes based on the gene expressions associated with T-cell activation. Expression profiles of molecules related to cell differentiation and biliary-stem cell markers were compared between the TME classes to investigate whether differences in tumor traits were associated with TME. Results Forty of 152 (26.3%) HCCs carried the Wnt/β-catenin mutations. Of these, 33 were classified as non-inflamed (33/40, 82.5%) and 7 as inflamed (7/40, 17.5%). Non-inflamed class was characterized by low number of CD3+, CD4+, and CD8+ cells on immunostaining, and high mRNA expressions of AXIN2 and GLUL, which are involved in the canonical Wnt/β-catenin signaling and hepatocyte differentiation, respectively. Non-inflamed tumors showed higher enhancement on the hepatobiliary-phase of gadolinium-ethoxybenzyl-diethylenetriamine (Gd-EOB-DTPA)-enhanced magnetic resonance imaging (MRI) compared to inflamed tumors. HCCs classified as inflamed class are revealed to have high numbers of CD3+, CD4+, and CD8+ tumor infiltrating lymphocytes on immunostaining. This class is associated with increased expression of anti-epithelial cell adhesion molecule (EpCAM) and FOXM1 accompanied by upregulation of genes related to interferon-gamma signaling, dendritic cell migration, regulatory T cells and MDSC activation and recognized as low enhancement nodule on Gd-EOB-DTPA-enhanced MRI. Conclusion Heterogeneity of tumor traits and TME was observed in HCC with Wnt/β-catenin mutation. The potential was indicated that tumor traits and TME are determined not only by the activation of the HNF4A but also by FOXM1, both of which are downstream transcription factor of the Wnt/β-catenin signaling pathway.
DOI: 10.6084/m9.figshare.24271237.v1
title: Supplementary Material for: Two distinct characteristics of immune microenvironment in human hepatocellular carcinoma with Wnt/β-catenin mutations

description: Introduction Immunotherapy is becoming a promising approach for unresectable-hepatocellular carcinoma (HCC); the anti-tumor response is affected by the tumor microenvironment (TME). Although Wnt/β-catenin mutations are reported to cause non-inflamed phenotype, their role on TME remains controversial. We aimed to clarify the heterogeneity of immunophenotype in HCC with Wnt/β-catenin mutations. Methods This study includes 152 resected HCCs; mutations in the catenin beta-1, adenomatous polyposis coli, or AXIN1, or AXIN2 genes were defined as Wnt/β-catenin mutations. With hierarchical cluster analyses, TME were classified into inflamed or non-inflamed classes based on the gene expressions associated with T-cell activation. Expression profiles of molecules related to cell differentiation and biliary-stem cell markers were compared between the TME classes to investigate whether differences in tumor traits were associated with TME. Results Forty of 152 (26.3%) HCCs carried the Wnt/β-catenin mutations. Of these, 33 were classified as non-inflamed (33/40, 82.5%) and 7 as inflamed (7/40, 17.5%). Non-inflamed class was characterized by low number of CD3+, CD4+, and CD8+ cells on immunostaining, and high mRNA expressions of AXIN2 and GLUL, which are involved in the canonical Wnt/β-catenin signaling and hepatocyte differentiation, respectively. Non-inflamed tumors showed higher enhancement on the hepatobiliary-phase of gadolinium-ethoxybenzyl-diethylenetriamine (Gd-EOB-DTPA)-enhanced magnetic resonance imaging (MRI) compared to inflamed tumors. HCCs classified as inflamed class are revealed to have high numbers of CD3+, CD4+, and CD8+ tumor infiltrating lymphocytes on immunostaining. This class is associated with increased expression of anti-epithelial cell adhesion molecule (EpCAM) and FOXM1 accompanied by upregulation of genes related to interferon-gamma signaling, dendritic cell migration, regulatory T cells and MDSC activation and recognized as low enhancement nodule on Gd-EOB-DTPA-enhanced MRI. Conclusion Heterogeneity of tumor traits and TME was observed in HCC with Wnt/β-catenin mutation. The potential was indicated that tumor traits and TME are determined not only by the activation of the HNF4A but also by FOXM1, both of which are downstream transcription factor of the Wnt/β-catenin signaling pathway.
DOI: 10.5281/zenodo.8421050
title: Amazon Rainforest Gross Primary Productivity (GPP) Dataset 2020 (Cleaned Updated .NC Files)

description: Amazon Rainforest Gross Primary Productivity (GPP) Dataset 2020 Product: Gross Primary Productivity (GPP) MODIS Tiles No: h11v09 and h12v09 Year: 2020 Region: Amazon Rainforest Temporal Scale: 8 Days Spatial Resolution: 500 meters Format: NetCDF (.nc) Projection: Geographic Lat/Long Method: Light-use-efficiency (LUE) approach. Referred Publication: https://www.sciencedirect.com/science/article/pii/S0048969718307149 https://onlinelibrary.wiley.com/doi/10.1111/gcb.12261
description: Please contact the authors for further details: S.bandopadhyay@soton.ac.uk j.dash@soton.ac.uk b.o.ogutu@soton.ac.uk
DOI: 10.5281/zenodo.8421049
title: Amazon Rainforest Gross Primary Productivity (GPP) Dataset 2020 (Cleaned Updated .NC Files)

description: Amazon Rainforest Gross Primary Productivity (GPP) Dataset 2020 Product: Gross Primary Productivity (GPP) MODIS Tiles No: h11v09 and h12v09 Year: 2020 Region: Amazon Rainforest Temporal Scale: 8 Days Spatial Resolution: 500 meters Format: NetCDF (.nc) Projection: Geographic Lat/Long Method: Light-use-efficiency (LUE) approach. Referred Publication: https://www.sciencedirect.com/science/article/pii/S0048969718307149 https://onlinelibrary.wiley.com/doi/10.1111/gcb.12261
description: Please contact the authors for further details: S.bandopadhyay@soton.ac.uk j.dash@soton.ac.uk b.o.ogutu@soton.ac.uk
DOI: 10.4121/315b5fdb-c361-4bfd-ba7a-962870fe5c18
title: Experimental data: Quantification of charge carriers and acetate diffusion lengths in intermittent electro-active biofilms using Electrochemical Impedance Spectroscopy

description: The data provided in these files have been generated/collected during the study on the effect of intermittent anode potential regimes on the development and current discharge of electro-active biofilms (EABfs). These data contain measured current density, acetate concentrations, biofilm development over time, and data from Electrochemical Impedance Spectroscopy.
DOI: 10.4121/315b5fdb-c361-4bfd-ba7a-962870fe5c18.v1
title: Experimental data: Quantification of charge carriers and acetate diffusion lengths in intermittent electro-active biofilms using Electrochemical Impedance Spectroscopy

description: The data provided in these files have been generated/collected during the study on the effect of intermittent anode potential regimes on the development and current discharge of electro-active biofilms (EABfs). These data contain measured current density, acetate concentrations, biofilm development over time, and data from Electrochemical Impedance Spectroscopy.
DOI: 10.6084/m9.figshare.24271243
title: <b>Incidence and risk factors of </b><b>postpartum depression in pregnant women with second child and establish predictive model</b>

description: To explore the incidence and associated risk factors of postpartum depression (PPD) in pregnant women with second child and establish predictive model, thus providing clinical guidance for reducing the incidence of PPD.
DOI: 10.15129/421856e3-3fa9-4d4d-9cbf-d9181dfdafdd
title: An updated 2018 UK SAM for CCS deployment with shipping in different industrial clusters

description: This is an updated 2018 Social Accounting Matrix (SAM) of the UK for use in projects aiming to explore the introduction of a Carbon Capture and Storage (CCS), transport and storage (T&S) specifically, sector in the UK economy. We include two variations: one for the Scottish cluster and another for the Viking cluster. In both, a mix of pipelines and shipping is used to transport captured CO2. As a starting point, the CCS sector is assumed to be identical, in terms of its supply chain and production technology, to the existing UK Oil and Gas sector. In fact, it has been created by disaggregating the Oil and Gas sector. However, as we are considering the case of CO2 transportation through a mix of pipelines and shipping is used, the inputs of the CCS sector are adjusted appropriately to reflect the fact that less capital is necessary to be owned and operated by the sector and at the same time more imports of shipping services are necessary. The scope of producing two variants of the SAM for each cluster is so that we can incorporate the different characteristics of each cluster in the structure of the T&S sector. This SAM incorporates the latest input-output tables published by the Office for National Statistics.
DOI: 10.6084/m9.figshare.24271288
title: Supplementary Material for: Two distinct characteristics of immune microenvironment in human hepatocellular carcinoma with Wnt/β-catenin mutations

description: Introduction Immunotherapy is becoming a promising approach for unresectable-hepatocellular carcinoma (HCC); the anti-tumor response is affected by the tumor microenvironment (TME). Although Wnt/β-catenin mutations are reported to cause non-inflamed phenotype, their role on TME remains controversial. We aimed to clarify the heterogeneity of immunophenotype in HCC with Wnt/β-catenin mutations. Methods This study includes 152 resected HCCs; mutations in the catenin beta-1, adenomatous polyposis coli, or AXIN1, or AXIN2 genes were defined as Wnt/β-catenin mutations. With hierarchical cluster analyses, TME were classified into inflamed or non-inflamed classes based on the gene expressions associated with T-cell activation. Expression profiles of molecules related to cell differentiation and biliary-stem cell markers were compared between the TME classes to investigate whether differences in tumor traits were associated with TME. Results Forty of 152 (26.3%) HCCs carried the Wnt/β-catenin mutations. Of these, 33 were classified as non-inflamed (33/40, 82.5%) and 7 as inflamed (7/40, 17.5%). Non-inflamed class was characterized by low number of CD3+, CD4+, and CD8+ cells on immunostaining, and high mRNA expressions of AXIN2 and GLUL, which are involved in the canonical Wnt/β-catenin signaling and hepatocyte differentiation, respectively. Non-inflamed tumors showed higher enhancement on the hepatobiliary-phase of gadolinium-ethoxybenzyl-diethylenetriamine (Gd-EOB-DTPA)-enhanced magnetic resonance imaging (MRI) compared to inflamed tumors. HCCs classified as inflamed class are revealed to have high numbers of CD3+, CD4+, and CD8+ tumor infiltrating lymphocytes on immunostaining. This class is associated with increased expression of anti-epithelial cell adhesion molecule (EpCAM) and FOXM1 accompanied by upregulation of genes related to interferon-gamma signaling, dendritic cell migration, regulatory T cells and MDSC activation and recognized as low enhancement nodule on Gd-EOB-DTPA-enhanced MRI. Conclusion Heterogeneity of tumor traits and TME was observed in HCC with Wnt/β-catenin mutation. The potential was indicated that tumor traits and TME are determined not only by the activation of the HNF4A but also by FOXM1, both of which are downstream transcription factor of the Wnt/β-catenin signaling pathway.
DOI: 10.6084/m9.figshare.24271288.v1
title: Supplementary Material for: Two distinct characteristics of immune microenvironment in human hepatocellular carcinoma with Wnt/β-catenin mutations

description: Introduction Immunotherapy is becoming a promising approach for unresectable-hepatocellular carcinoma (HCC); the anti-tumor response is affected by the tumor microenvironment (TME). Although Wnt/β-catenin mutations are reported to cause non-inflamed phenotype, their role on TME remains controversial. We aimed to clarify the heterogeneity of immunophenotype in HCC with Wnt/β-catenin mutations. Methods This study includes 152 resected HCCs; mutations in the catenin beta-1, adenomatous polyposis coli, or AXIN1, or AXIN2 genes were defined as Wnt/β-catenin mutations. With hierarchical cluster analyses, TME were classified into inflamed or non-inflamed classes based on the gene expressions associated with T-cell activation. Expression profiles of molecules related to cell differentiation and biliary-stem cell markers were compared between the TME classes to investigate whether differences in tumor traits were associated with TME. Results Forty of 152 (26.3%) HCCs carried the Wnt/β-catenin mutations. Of these, 33 were classified as non-inflamed (33/40, 82.5%) and 7 as inflamed (7/40, 17.5%). Non-inflamed class was characterized by low number of CD3+, CD4+, and CD8+ cells on immunostaining, and high mRNA expressions of AXIN2 and GLUL, which are involved in the canonical Wnt/β-catenin signaling and hepatocyte differentiation, respectively. Non-inflamed tumors showed higher enhancement on the hepatobiliary-phase of gadolinium-ethoxybenzyl-diethylenetriamine (Gd-EOB-DTPA)-enhanced magnetic resonance imaging (MRI) compared to inflamed tumors. HCCs classified as inflamed class are revealed to have high numbers of CD3+, CD4+, and CD8+ tumor infiltrating lymphocytes on immunostaining. This class is associated with increased expression of anti-epithelial cell adhesion molecule (EpCAM) and FOXM1 accompanied by upregulation of genes related to interferon-gamma signaling, dendritic cell migration, regulatory T cells and MDSC activation and recognized as low enhancement nodule on Gd-EOB-DTPA-enhanced MRI. Conclusion Heterogeneity of tumor traits and TME was observed in HCC with Wnt/β-catenin mutation. The potential was indicated that tumor traits and TME are determined not only by the activation of the HNF4A but also by FOXM1, both of which are downstream transcription factor of the Wnt/β-catenin signaling pathway.