cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.12849959.v1
title: Metformin reduces autoimmune antibody levels in patients with Hashimoto’s thyroiditis: A systematic review and meta-analysis

description: In the past few years, an increasing number of studies have proposed the idea of extending the therapeutic range of metformin from traditional hypoglycaemic to autoimmune diseases, and confirmed in a variety of autoimmune diseases. However, whether metformin can be used to treat Hashimoto’s thyroiditis (HT), which is characterised by thyroid peroxidase antibody (TPOAb) and thyroglobulin antibody (TgAb), is unknown. Therefore, we conducted a systematic review and meta-analysis to evaluate whether metformin can reduce the levels of TPOAb and TgAb in patients with HT or subclinical hypothyroidism (SH), so as to provide a theoretical basis for metformin treatment of these diseases. PubMed, Web Of Science and Embase were searched for observational studies investigating the changes of TPOAb and TgAb in patients with HT after metformin treatment. Two authors extracted data from eligible studies and classified them as HT and subclinical hypothyroidism subgroups. The calculation was then performed by weighted mean difference (WMD) combined with a fixed-effects model analysis or standard mean difference (SMD) with a random-effects model analysis, based on the measurement of the outcome. Metformin significantly reduced TPOAb levels and TgAb levels in patients with HT and SH, especially TPOAb (HT: <i>p</i> <sub>TPOAb</sub> = .009, <i>p</i> <sub>TgAb</sub> = .046; SH: <i>p</i> <sub>TPOAb</sub> = .034, <i>p</i> <sub>TgAb</sub> = .066). In addition, metformin also reduced the levels of thyroid stimulating hormone (TSH), homeostasis model assessment of insulin resistance (HOMA-IR) in patients with HT and SH (HT: <i>p</i> <sub>TSH</sub> = .000 and <i>p</i> <sub>HOMA-IR</sub> = .000; SH: <i>p</i> <sub>TSH</sub> = .000 and <i>p</i> <sub>HOMA-IR</sub> = .000, respectively). Metformin significantly reduces TPOAb level and TgAb level in patients with HT and SH, especially TPOAb. This study is the first to provide a preliminary theoretical basis for the clinical application of metformin in the treatment of HT.
DOI: 10.6084/m9.figshare.5268649.v1
title: iRF scripts and data

description: This repository contains all scripts and data used in the case studies and simulations of <i>iterative Random Forests to discover predictive and stable high-order interactions</i>.
DOI: 10.6084/m9.figshare.5268148
title: NEON Phenology & Temp Time Series Teaching Data Subset (v1 - 2016 data)

description: This teaching data set contains a sample of NEON plant phenology and single-aspirated air temperature data collected in 2016. This teaching data subset was used for several tutorials on the NEON website (neonscience.org) that have now been updated to use a newer version of analogous data. The structure of these data differ slightly from the structure of the data delivered by NEON after 2019. <br>The dataset is for educational purposes, data for research purposes can be obtained from the NEON Data Portal (data.neonscience.org).
DOI: 10.6084/m9.figshare.5268061
title: Immunohistochemical detection of C9orf72 protein in frontotemporal lobar degeneration and motor neurone disease: patterns of immunostaining and an evaluation of commercial antibodies

description: We have employed as ‘gold standards’ two in-house, well-characterised and validated polyclonal antibodies, C9-L and C9-S, which detect the longer and shorter forms of C9orf72, and have compared seven other commercially available antibodies with these in order to evaluate the utility of the latter as credible tools for the demonstration of C9orf72. C9-L and C9-S antibodies immunostained cytoplasmic ‘speckles’, and the nuclear membrane, respectively, in cerebellar Purkinje cells of the cerebellum in patients with behavioural variant frontotemporal dementia (bvFTD) with amyotrophic lateral sclerosis (ALS), and in patients with ALS alone. Similar staining was seen in Purkinje cells in healthy control tissues and in other neurodegenerative disorders, and in pyramidal cells of CA4 and dentate gyrus of hippocampus. However, in the spinal cord there was little cytoplasmic staining with C9-L antibody. C9-S antibody immunostained the nuclear membrane of anterior horn cells in healthy neurons. In patients with bvFTD + ALS, or ALS alone, this C9-S nuclear staining was redistributed to the plasma membrane. In those patients with bvFTD + ALS or ALS bearing an expansion in <i>C9orf72</i>, none of the commercially available antibodies detected TDP-43 inclusions in anterior horn cells, nor were dipeptide repeat proteins demonstrated. Five of the commercial antibodies provided immunohistochemical staining patterns similar in morphological appearance to the in-house C9-L antibody, but distinct from C9-S antibody. However, only three showed sufficient specificity and intensity of staining for C9orf72 at acceptably low concentrations, to make them of practical value and sufficiently reliable for the detection of at least the longer form of C9orf72 protein.
DOI: 10.6084/m9.figshare.5268058
title: Data - Worldclim and GBIF

description: Environment variables are from Worldclim (http://worldclim.org/) and occurrence data, available at GBIF (http://www.gbif.org/) use in Pet snakes Illegally marketed in Brazil: Climatic viability and establishment risk<br>
DOI: 10.6084/m9.figshare.5268061.v1
title: Immunohistochemical detection of C9orf72 protein in frontotemporal lobar degeneration and motor neurone disease: patterns of immunostaining and an evaluation of commercial antibodies

description: We have employed as ‘gold standards’ two in-house, well-characterised and validated polyclonal antibodies, C9-L and C9-S, which detect the longer and shorter forms of C9orf72, and have compared seven other commercially available antibodies with these in order to evaluate the utility of the latter as credible tools for the demonstration of C9orf72. C9-L and C9-S antibodies immunostained cytoplasmic ‘speckles’, and the nuclear membrane, respectively, in cerebellar Purkinje cells of the cerebellum in patients with behavioural variant frontotemporal dementia (bvFTD) with amyotrophic lateral sclerosis (ALS), and in patients with ALS alone. Similar staining was seen in Purkinje cells in healthy control tissues and in other neurodegenerative disorders, and in pyramidal cells of CA4 and dentate gyrus of hippocampus. However, in the spinal cord there was little cytoplasmic staining with C9-L antibody. C9-S antibody immunostained the nuclear membrane of anterior horn cells in healthy neurons. In patients with bvFTD + ALS, or ALS alone, this C9-S nuclear staining was redistributed to the plasma membrane. In those patients with bvFTD + ALS or ALS bearing an expansion in <i>C9orf72</i>, none of the commercially available antibodies detected TDP-43 inclusions in anterior horn cells, nor were dipeptide repeat proteins demonstrated. Five of the commercial antibodies provided immunohistochemical staining patterns similar in morphological appearance to the in-house C9-L antibody, but distinct from C9-S antibody. However, only three showed sufficient specificity and intensity of staining for C9orf72 at acceptably low concentrations, to make them of practical value and sufficiently reliable for the detection of at least the longer form of C9orf72 protein.
DOI: 10.6084/m9.figshare.5268037
title: MBLWHOI network files prepared for Symplectic Elements Workshop

description: Network data generated from MBLWHOI Elements Database
DOI: 10.6084/m9.figshare.5268184.v3
title: University of Surrey Case Study

description: A case study with the University of Surrey discussing their use of the Altmetric Explorer for Institutions.
DOI: 10.6084/m9.figshare.5268037.v1
title: MBLWHOI network files prepared for Symplectic Elements Workshop

description: Network data generated from MBLWHOI Elements Database
DOI: 10.6084/m9.figshare.5268058.v1
title: Data - Worldclim and GBIF

description: Environment variables are from Worldclim (http://worldclim.org/) and occurrence data, available at GBIF (http://www.gbif.org/) use in Pet snakes Illegally marketed in Brazil: Climatic viability and establishment risk<br>
DOI: 10.6084/m9.figshare.5268148.v1
title: NEON Phenology & Temp Time Series Teaching Data Subset

description: This teaching data set contains a sample of NEON plant phenology and single-aspirated air temperature data. They are provided for use with online tutorials designed to teach how to work with NEON phenology and temperature data.<br>This teaching data subset is used for several tutorials on the NEON website (neonscience.org). The dataset is for educational purposes, data for research purposes can be obtained from the NEON Data Portal (data.neonscience.org).<br>
DOI: 10.6084/m9.figshare.5268007
title: <i>Orthrozanclus elongata</i> NIGPAS164893B - detail

description: Orthrozanclus elongata NIGPAS164893B - details of specimen under various lighting conditions
DOI: 10.6084/m9.figshare.5268025
title: The cranial morphology of <i>Anosteira maomingensis</i> (Testudines, Pan-Carettochelys) and the evolution of pan-carettochelyid turtles

description: This paper describes the cranial morphology of <i>Anosteira maomingensis</i>, a turtle of the clade Pan-Carettochelys, based on a skull that is part of a more complete specimen from the middle-upper Eocene Youganwo Formation of Maoming, Guangdong Province, China. The cranial data of <i>An. maomingensis</i> were included in a phylogenetic analysis of pan-carettochelyids, one that was complemented with new codings and characters and also including cranial and non-shell postcranial characters of <i>Kizylkumemys schultzi</i> (Late Cretaceous of Uzbekistan). It also included characters of vertebral scutes of pan-carettochelyids based on a newly proposed nomenclature of vertebral scutes for this group. The result of our phylogenetic analyses supports a recently proposed hypothesis of probable paraphyly of Anosteirinae, <i>Kizylkumemys, Anosteira</i>, and <i>Allaeochelys</i>. In addition, our study summarizes data on cranial morphology of pan-carettochelyid turtles and discusses some aspects of their evolution.
DOI: 10.6084/m9.figshare.5267998
title: <i>Orthrozanclus elongata</i> NIGPAS164893B

description: Orthrozanclus elongata NIGPAS164893B - photographs of entire specimen under selected lighting conditions
DOI: 10.6084/m9.figshare.5268007.v1
title: <i>Orthrozanclus elongata</i> NIGPAS164893B - detail

description: Orthrozanclus elongata NIGPAS164893B - details of specimen under various lighting conditions
DOI: 10.6084/m9.figshare.5268025.v1
title: The cranial morphology of <i>Anosteira maomingensis</i> (Testudines, Pan-Carettochelys) and the evolution of pan-carettochelyid turtles

description: This paper describes the cranial morphology of <i>Anosteira maomingensis</i>, a turtle of the clade Pan-Carettochelys, based on a skull that is part of a more complete specimen from the middle-upper Eocene Youganwo Formation of Maoming, Guangdong Province, China. The cranial data of <i>An. maomingensis</i> were included in a phylogenetic analysis of pan-carettochelyids, one that was complemented with new codings and characters and also including cranial and non-shell postcranial characters of <i>Kizylkumemys schultzi</i> (Late Cretaceous of Uzbekistan). It also included characters of vertebral scutes of pan-carettochelyids based on a newly proposed nomenclature of vertebral scutes for this group. The result of our phylogenetic analyses supports a recently proposed hypothesis of probable paraphyly of Anosteirinae, <i>Kizylkumemys, Anosteira</i>, and <i>Allaeochelys</i>. In addition, our study summarizes data on cranial morphology of pan-carettochelyid turtles and discusses some aspects of their evolution.
DOI: 10.6084/m9.figshare.5267956
title: Orthrozanclus elongata NIGPAS164892B - detail

description: Orthrozanclus elongata NIGPAS164892B - detailed images under a variety of lighting conditions
DOI: 10.6084/m9.figshare.5267998.v1
title: <i>Orthrozanclus elongata</i> NIGPAS164893B

description: Orthrozanclus elongata NIGPAS164893B - photographs of entire specimen under selected lighting conditions
DOI: 10.6084/m9.figshare.12801110.v1
title: AMBER barreir density polygons and field validation catchments

description: Spatial base layers used in Figure 2 and Extended Data Figure 3 of Belletti et al. (2020). Derived from European catchments and Rivers network system
DOI: 10.6084/m9.figshare.5267956.v1
title: Orthrozanclus elongata NIGPAS164892B - detail

description: Orthrozanclus elongata NIGPAS164892B - detailed images under a variety of lighting conditions
DOI: 10.6084/m9.figshare.5267938
title: Orthrozanclus elongata NIGPAS164893A - entire specimen

description: NIGPAS164892A - entire specimen
DOI: 10.6084/m9.figshare.5267899
title: Orthrozanclus elongata NIGPAS164892A - entire specimen

description: NIGPAS164892A, entire specimen
DOI: 10.6084/m9.figshare.5267899.v1
title: Orthrozanclus elongata NIGPAS164892A - entire specimen

description: NIGPAS164892A, entire specimen
DOI: 10.6084/m9.figshare.5267827
title: First record of fossil Trachycarpeae in Africa: three new species of <i>Palmoxylon</i> from the Oligocene (Rupelian) Gebel Qatrani Formation, Fayum, Egypt

description: Based on a survey of the fossil wood flora of Gebel Qatrani (Rupelian, Fayum, Egypt), three new species of palm stem are described: <i>Palmoxylon araneus</i> Nour-El-Deen, El-Saadawi & Thomas sp. nov., <i>Palmoxylon elsaadawii</i> Nour-El-Deen & Thomas sp. nov. and <i>Palmoxylon qatraniense</i> Nour-El-Deen, El-Saadawi & Thomas sp. nov. The specimens are the first petrified palm wood to be reported from the deposits in the upper sequence of the Gebel Qatrani Formation. They are characterized by fibrovascular bundles with two vessels, the presence of a ground parenchyma sustained growth, fibrous bundles, globular echinate phytoliths, radiating parenchyma, and multiseriate scalariform thickening of metaxylem elements. Palaeoclimatic inferences and comparisons with similar fossil stems are discussed for each of the three taxa. Comparisons with extant palms allow identification of these species to tribal (Trachycarpeae) and subfamilial (Coryphoideae) levels. They are the first representatives of tribe Trachycarpeae on the African continent. An attempt is also made to explain migration events and discuss the current and fossil distribution of the tribe in Africa.
DOI: 10.6084/m9.figshare.5267824
title: Supplementary Material for: Septic Complications after Resection for Middle or Low Rectal Cancer: Role of Gut Barrier Function and Inflammatory Serum Markers

description: <b><i>Background:</i></b> The focus of this study was to understand the relationship between the failure of gut barrier function, inflammatory markers and septic complications after resection for extraperitoneal rectal cancer. <b><i>Methods:</i></b> One hundred seven patients were enrolled into this prospective observational study and underwent open colorectal resection for extraperitoneal cancer. All patients underwent an assessment of intestinal permeability (L/M ratio), endotoxemia, interleukin-1β (IL-1β), interleukin-6 (IL-6), C-reactive protein (CRP) and elastase levels before surgery and on postoperative days 1, 3, and 7. <b><i>Results:</i></b> Septic complications developed in 23.3% of patients. There were no significant differences in preoperative L/M ratio, endotoxine, CRP, interleukin-1 (IL-1), IL-6, and elastase levels between septic and non-septic groups. All patients showed a significant increase in intestinal permeability, endotoxemia, IL-1, IL-6, CRP, and elastase on the first postoperative day. At postoperative day 7, the septic group continued to demonstrate an increase in intestinal permeability, endotoxemia and elastase and significant difference was observed between the 2 groups (<i>p</i> &lt; 0.05), whereas there was no significant difference in IL-1, IL-6, and CRP levels. <b><i>Conclusion:</i></b> The pattern of change in the postoperative period of intestinal permeability, systemic endotoxemia and elastase concentration is significantly higher in patients in whom sepsis develops, while the concentration of IL-1β, IL-6, and CRP does not permit to distinguish infection from inflammation.
DOI: 10.6084/m9.figshare.5267827.v1
title: First record of fossil Trachycarpeae in Africa: three new species of <i>Palmoxylon</i> from the Oligocene (Rupelian) Gebel Qatrani Formation, Fayum, Egypt

description: Based on a survey of the fossil wood flora of Gebel Qatrani (Rupelian, Fayum, Egypt), three new species of palm stem are described: <i>Palmoxylon araneus</i> Nour-El-Deen, El-Saadawi & Thomas sp. nov., <i>Palmoxylon elsaadawii</i> Nour-El-Deen & Thomas sp. nov. and <i>Palmoxylon qatraniense</i> Nour-El-Deen, El-Saadawi & Thomas sp. nov. The specimens are the first petrified palm wood to be reported from the deposits in the upper sequence of the Gebel Qatrani Formation. They are characterized by fibrovascular bundles with two vessels, the presence of a ground parenchyma sustained growth, fibrous bundles, globular echinate phytoliths, radiating parenchyma, and multiseriate scalariform thickening of metaxylem elements. Palaeoclimatic inferences and comparisons with similar fossil stems are discussed for each of the three taxa. Comparisons with extant palms allow identification of these species to tribal (Trachycarpeae) and subfamilial (Coryphoideae) levels. They are the first representatives of tribe Trachycarpeae on the African continent. An attempt is also made to explain migration events and discuss the current and fossil distribution of the tribe in Africa.
DOI: 10.6084/m9.figshare.5267815
title: Supplementary Material for: Tracking Cognitive Decline in Amnestic Mild Cognitive Impairment and Early-Stage Alzheimer Dementia: Mini-Mental State Examination versus Neuropsychological Battery

description: <b><i>Background/Aims:</i></b> Although the Mini-Mental State Examination (MMSE), Clinical Dementia Rating-Sum of Boxes (CDR-SOB), and neuropsychological batteries are widely used for evaluating cognitive function, it remains elusive which instrument best reflects the longitudinal disease progression in amnestic mild cognitive impairment (aMCI) and probable Alzheimer disease (AD). We investigated whether changes in these three instruments over time correlate with loss of cortical gray matter volume (cGMV). <b><i>Methods:</i></b> We retrospectively investigated 204 patients (aMCI, <i>n</i> = 114; AD, <i>n</i> = 90) who had undergone MMSE, CDR-SOB, the dementia version of the Seoul Neuropsychological Screening Battery (SNSB-D), and 3-dimensional T1-weighted magnetic resonance images at least twice. We investigated the partial correlation between annual decline in test scores and percent change of cGMV. <b><i>Results:</i></b> In aMCI patients, changes in the SNSB-D total score (<i>r</i> = 0.340, <i>p</i> &lt; 0.001) and CDR-SOB (<i>r</i> = 0.222, <i>p</i> = 0.020), but not MMSE, showed a correlation with cGMV loss, with the SNSB-D total score showing the strongest correlation. In AD patients, decline in all three test scores correlated significantly with cGMV loss, with MMSE exhibiting the strongest correlation (<i>r</i> = 0.464, <i>p</i> &lt; 0.001). <b><i>Conclusion:</i></b> In aMCI patients, neuropsychological battery, though time-consuming, was the most adequate tool in tracking disease progression. In AD patients, however, MMSE may be the most effective longitudinal monitoring tool when considering cost-effectiveness.
DOI: 10.6084/m9.figshare.5267818
title: Supplementary Material for: Presence of Concomitant Systemic Cancer is Not Associated with Worse Functional Long-Term Outcome in Patients with Intracerebral Hemorrhage

description: <b><i>Background:</i></b> Data on clinical characteristics and outcome of patients with intracerebral hemorrhage (ICH) and concomitant systemic cancer disease are very limited. <b><i>Methods:</i></b> Nine hundred and seventy three consecutive primary ICH patients were analyzed using our prospective institutional registry over a period of 9 years (2006-2014). We compared clinical and radiological parameters as well as outcome - scored using the modified Rankin Scale (mRS) and analyzed in a dichotomized fashion as favorable outcome (mRS = 0-3) and unfavorable outcome (mRS = 4-6) - of ICH patients with and without cancer. Relevant imbalances in baseline clinical and radiological characteristics were adjusted using propensity score (PS) matching. <b><i>Results:</i></b> Prevalence of systemic cancer among patients with ICH was 8.5% (83/973). ICH patients with cancer were older (77 [70-82] vs. 72 [63-80] years; <i>p</i> = 0.002), had more often prior renal dysfunction (19/83 [22.9%] vs.107/890 [12.0%]; <i>p</i> = 0.005), and smaller hemorrhage volumes (10.1 [4.8-24.3] vs. 15.3 [5.4-42.9] mL; <i>p</i> = 0.017). After PS-matching there were no significant differences neither in mortality nor in functional outcome both at 3 months (mortality: 33/81 [40.7%] vs. 55/158 [34.8%]; <i>p</i> = 0.368; mRS = 0-3: 28/81 [34.6%] vs. 52/158 [32.9%]; <i>p</i> = 0.797) and 12 months (mortality: 39/78 [50.0%] vs. 70/150 [46.7%]; <i>p</i> = 0.633; mRS = 0-3: 25/78 [32.1%] vs. 53/150 [35.3%]; <i>p</i> = 0.620) among patients with and without concomitant systemic cancer. ICH volume tended to be highest in patients with hematooncologic malignancy and smallest in urothelial cancer. <b><i>Conclusions:</i></b> Patients with ICH and concomitant systemic cancer on average are older; however, they show smaller ICH volumes compared to patients without cancer. Yet, mortality and functional outcome is not different in ICH patients with and without cancer. Thus, the clinical history or the de novo diagnosis of concomitant malignancies in ICH patients should not lead to unjustified treatment restrictions.
DOI: 10.6084/m9.figshare.5267743
title: Burden of rheumatoid arthritis in the Nordic region, 1990–2015: a comparative analysis using the Global Burden of Disease Study 2015

description: <b>Objective</b>: To report mortality and disability due to rheumatoid arthritis (RA) in the Nordic region (Denmark, Finland, Greenland, Iceland, Norway, and Sweden) using data from the Global Burden of Disease Study (GBD) 2015. <b>Method</b>: Using the results of GBD 2015, we present rates and trends in prevalence, mortality, years of life lost, years lived with disability (YLD), and disability-adjusted life-years (DALYs) of RA in the Nordic region during 1990–2015. <b>Results</b>: In 2015, the age-standardized prevalence of RA was higher in the Nordic region than the global level (0.44%, 95% uncertainty interval 0.40–0.48%, vs 0.35%, 0.32–0.38%). For women (men), DALYs increased by 2.4% (12.9%), from 29 263 (10 909) in 1990 to 29 966 (12 311) in 2015. The burden of RA as a proportion of total DALYs in women (men) increased from 0.90% (0.29%) in 1990 to 0.94% (0.36%) in 2015. Age-standardized DALY rates declined in all countries except Denmark and Greenland between 1990 and 2015. Of 315 conditions studied, RA was ranked as the 16th (37th) leading cause of YLD in women (men) in the region. Of 195 countries studied, Greenland, Finland, Denmark, Norway, Sweden, and Iceland had the 7th, 11th, 28th, 38th, 48th, and 78th highest age-standardized YLD rates for RA, respectively. <b>Conclusions</b>: The prevalence of RA in the Nordic region is higher than the global average. Current trends in population growth and ageing suggest a potential increase in RA burden in the coming decades in the region that should be considered in healthcare resources allocation.
DOI: 10.15131/shef.data.5267722
title: Shear database of FRP RC beams with shear FRP reinforcement

description: This database collects the main experimental results form the tests performed on the FRP reinforced concrete beams with FRP shear reinforcement.<br>Note: A description of each spreadsheet column is available as a comment, on downloading and opening the excel file.