cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.15468/dl.wnj2hc
title: Occurrence Download

description: A dataset containing 22 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Eupithecia takao Inoue, 1955",
 "HasCoordinate is true",
 "Country is Japan",
 "HasGeospatialIssue is false"
 ]
}

 The dataset includes 22 records from 5 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0223255-220831081235567/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.b3u4b4
title: Occurrence Download

description: A dataset containing 71686 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Geometry POLYGON((28.49 68.35,30.49 68.35,30.49 70.35,28.49 70.35,28.49 68.35))",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 "TaxonKey is Plantae"
 ]
}

 The dataset includes 71686 records from 104 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0248020-230224095556074/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.cv5qsf
title: Occurrence Download

description: A dataset containing 28 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Wagnerinus costatus Korotyaev, 1981",
 "HasCoordinate is true",
 "Country is Japan",
 "HasGeospatialIssue is false"
 ]
}

 The dataset includes 28 records from 2 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0223256-220831081235567/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.5gfvpk
title: Occurrence Download

description: A dataset containing 178 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Geometry POLYGON((-67.85026 41.31143,-75.67099 47.02811,-99.92715 34.84048,-96.55273 28.01223,-79.87909 27.21824,-67.85026 41.31143))",
 "TaxonKey is Quercus prinus L."
 ]
}

 The dataset includes 178 records from 36 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0259031-230224095556074/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.qq88b3
title: Occurrence Download

description: A dataset containing 41311 species occurrences available in GBIF matching the query:
{
 "Geometry" : [
 "POLYGON((6.59153 46.51114,6.63473 46.51114,6.63473 46.53772,6.59153 46.53772,6.59153 46.51114))"
 ]
}

 The dataset includes 41311 records from 70 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0043576-230530130749713/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.9zm8ba
title: Occurrence Download

description: A dataset containing 35 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Guzmania caricifolia (André) L.B.Sm."
 ]
}

 The dataset includes 35 records from 12 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0234214-230224095556074/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.u6yskm
title: Occurrence Download

description: A dataset containing 94 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Synuchus dulcigradus (Bates, 1873)",
 "HasCoordinate is true",
 "Country is Japan",
 "HasGeospatialIssue is false"
 ]
}

 The dataset includes 94 records from 11 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0211994-220831081235567/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.pzd3u8
title: Occurrence Download

description: A dataset containing 9 species occurrences available in GBIF matching the query:
{
 "and" : [
 "GadmGid is CHN.30_1",
 "OccurrenceStatus is Present",
 "TaxonKey is Aix galericulata (Linnaeus, 1758)",
 "Year 2000-2020"
 ]
}

 The dataset includes 9 records from 2 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0004266-230530130749713/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.xhdqnu
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Istocheta aldrichi (Mesnil, 1953)",
 "HasCoordinate is true",
 "Country is Japan",
 "HasGeospatialIssue is false"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0212005-220831081235567/datasets/export for details.
DOI: 10.15468/dl.ymjpaz
title: Occurrence Download

description: A dataset containing 27 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Glaphyra kojimai Niisato, 2007",
 "HasCoordinate is true",
 "Country is Japan",
 "HasGeospatialIssue is false"
 ]
}

 The dataset includes 27 records from 7 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0211996-220831081235567/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.9gs5kc
title: Occurrence Download

description: A dataset containing 36 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Opistophthalmus fitzsimonsi Hewitt, 1935)",
 "HasCoordinate is true"
 ]
}

 The dataset includes 36 records from 3 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0015121-250402121839773/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.6084/m9.figshare.27262470.v1
title: Data.zip

description: Raw data in the article.
DOI: 10.15468/dl.w7nbbr
title: Occurrence Download

description: A dataset containing 1642 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Geometry POLYGON ((120.642 30.46298, 120.7494 30.46298, 120.7494 30.55714, 120.642 30.55714, 120.642 30.46298))",
 "Year is greater than or equal to 2013",
 "HasGeospatialIssue is false",
 "TaxonKey is Aves",
 "HasCoordinate is true",
 "OccurrenceStatus is Present",
 {
 "not" : {
 "BasisOfRecord" : [
 "is one of (Fossil, Living Specimen, Specimen)"
 ]
 }
 }
 ]
}

 The dataset includes 1642 records from 3 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0001347-241107131044228/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.25442/hku.27330120
title: <i>Supporting data for </i><i>“The Function of LEM-3 Endonuclease in Regulating Cell Fate Determination”</i>

description: This project studies the effects of LEM-3 on cell fate determination in the nematode <i>Caenorhabditis elegans</i>. The study was mostly performed in the touch receptor neurons (TRNs) of <i>C.elegans</i>. There are six TRNs in C.elegans, including ALML, ALMR, PLML, PLMR, AVM, and PVM. We knocked out the <i>lem-3 </i>gene in C. elegans, labeled various neurons with fluorescent proteins driven by specific gene promoters, and observed the effects of <i>lem-3</i> knockout on neuronal cell fate. We also used various biochemical methods to manipulate biological processes in <i>C. elegans</i>, such as using drugs to regulate the activity of topoisomerases to block the DNA replication process. One feature of the cell fate change caused by abnormal <i>lem-3</i> is that its absence causes the formation of intercellular channels between neurons and sister neurons. We evaluated the degree to which cell fate was affected in different situations by quantifying the penetrance of intercellular canals.Figure 3C, 3D, 12C, 14B, 21: penetrance of intercellular canals in different neuronal subtypes; Figure 7E: percentage of independent and mixed transcription of genes in different types of syncytia; Figure 9B: length of intercellular canals at different time points during <i>C.elegans</i> development; Figure 10B, 10C: intensity of fluorescent signals in different neuronal subtypes; Figure 12B: percentage of nuclear membrane connections in syncytia; Figure 15C: penetrance of intercellular canals in AVM neurons under different experimental conditions. Figure 16A: percentage of different syncytia types; Figure 17E: Ratio of different cell fate-affecting outcomes.<br>
DOI: 10.25442/hku.27330120.v1
title: <i>Supporting data for </i><i>“The Function of LEM-3 Endonuclease in Regulating Cell Fate Determination”</i>

description: This project studies the effects of LEM-3 on cell fate determination in the nematode <i>Caenorhabditis elegans</i>. The study was mostly performed in the touch receptor neurons (TRNs) of <i>C.elegans</i>. There are six TRNs in C.elegans, including ALML, ALMR, PLML, PLMR, AVM, and PVM. We knocked out the <i>lem-3 </i>gene in C. elegans, labeled various neurons with fluorescent proteins driven by specific gene promoters, and observed the effects of <i>lem-3</i> knockout on neuronal cell fate. We also used various biochemical methods to manipulate biological processes in <i>C. elegans</i>, such as using drugs to regulate the activity of topoisomerases to block the DNA replication process. One feature of the cell fate change caused by abnormal <i>lem-3</i> is that its absence causes the formation of intercellular channels between neurons and sister neurons. We evaluated the degree to which cell fate was affected in different situations by quantifying the penetrance of intercellular canals.Figure 3C, 3D, 12C, 14B, 21: penetrance of intercellular canals in different neuronal subtypes; Figure 7E: percentage of independent and mixed transcription of genes in different types of syncytia; Figure 9B: length of intercellular canals at different time points during <i>C.elegans</i> development; Figure 10B, 10C: intensity of fluorescent signals in different neuronal subtypes; Figure 12B: percentage of nuclear membrane connections in syncytia; Figure 15C: penetrance of intercellular canals in AVM neurons under different experimental conditions. Figure 16A: percentage of different syncytia types; Figure 17E: Ratio of different cell fate-affecting outcomes.<br>
DOI: 10.25442/hku.27314571
title: Supporting data for “Identification and characterization of pharmacologically active small molecules modulating spheroid attachment and embryo implantation”

description: Infertility affects millions of couples worldwide, with embryo implantation failure being one of the biggest challenges. This research aims to identify and characterize small molecules that can enhance endometrial receptivity and embryo implantation. A multi-step approach was used, including high-throughput screening of 1280 small molecules from the Library of Pharmacologically Active Compounds (LOPAC), bioinformatics analysis, and in vitro co-culture assays with non-receptive endometrial cells to identify promising compounds. RNA sequencing and quantitative PCR were applied to assess differential gene expression, focusing on pathways relevant to implantation. In vivo validation was conducted using a transcervical delivery system in a mouse model, with implantation sites marked by Chicago blue dye at specific time points to precisely evaluate implantation outcomes​​​.
DOI: 10.15468/dl.ttpct8
title: Occurrence Download

description: A dataset containing 22 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Cyperus majestuosus (P.A.Duvign. & G.Léonard) Bauters",
 "Continent is Africa"
 ]
}

 The dataset includes 22 records from 3 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0001348-241107131044228/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.25442/hku.27313137
title: Supporting data for “<b>Human Lipocalin-2 Variants: Therapeutic Evaluations</b>”

description: Neutrophil extracellular traps (NETs) play a key role in the immune response to inflammatory stimuli but can lead to chronic inflammation when produced in excess. This study investigates the dual role of NETs in both infectious and sterile inflammation, particularly in the context of cardiovascular disease. We focused on the association of lipocalin-2 variants—specifically polyaminated lipocalin-2 (hLcn2), non-polyaminated lipocalin-2 (C87A), and highly polyaminated lipocalin-2 (R81E)—with NETs formation and inflammatory processes. Using transgenic TG-hLcn2/LKO and global lipocalin-2 knockout (LKO) mouse models, we examined the expression of these lipocalin-2 variants during high-fat dietary exposure and assessed their effects on neutrophil lifespan and phenotype.Following a high-fat diet, our findings demonstrated that C87A levels were significantly elevated in cardiac and epididymal white adipose tissue (eWAT). Neutralization with an anti-C87A antibody effectively reduced NET formation and downregulated key inflammatory chemokines, including CXCL1 and CXCL2, which are critical for recruiting neutrophils via the CXCR4 chemokine receptor. Enhanced signalling through CXCR4 was observed in the presence of elevated C87A, correlating with increased neutrophil infiltration and NETosis, suggesting a direct link between lipocalin-2 variants and the regulation of neutrophil activity in inflammatory conditions.Furthermore, we assessed the pathogenic role of C87A in models of obesity-induced hypertension and heart failure with preserved ejection fraction (HFpEF). Our results showed that modulation of C87A not only decreased neutrophil infiltration and NETosis but also mitigated the associated cardiovascular complications. Additionally, macrophage polarization was found to be protective against C87A-induced inflammation, while astrocytes in the brain contributed to obesity-induced hypertension through the paracrine release of inflammatory factors, including lipocalin-2.These findings highlight the complex interplay between lipocalin-2 variants, NETs, and inflammation, suggesting that targeting lipocalin-2 variant C87A may represent a novel therapeutic strategy to mitigate chronic inflammatory conditions and their cardiovascular complications. This research underscores the importance of understanding the mechanisms underlying NETs formation and the potential for lipocalin-2 variants as therapeutic targets in managing obesity-related cardiovascular diseases.
DOI: 10.25442/hku.27313137.v1
title: Supporting data for “<b>Human Lipocalin-2 Variants: Therapeutic Evaluations</b>”

description: Neutrophil extracellular traps (NETs) play a key role in the immune response to inflammatory stimuli but can lead to chronic inflammation when produced in excess. This study investigates the dual role of NETs in both infectious and sterile inflammation, particularly in the context of cardiovascular disease. We focused on the association of lipocalin-2 variants—specifically polyaminated lipocalin-2 (hLcn2), non-polyaminated lipocalin-2 (C87A), and highly polyaminated lipocalin-2 (R81E)—with NETs formation and inflammatory processes. Using transgenic TG-hLcn2/LKO and global lipocalin-2 knockout (LKO) mouse models, we examined the expression of these lipocalin-2 variants during high-fat dietary exposure and assessed their effects on neutrophil lifespan and phenotype.Following a high-fat diet, our findings demonstrated that C87A levels were significantly elevated in cardiac and epididymal white adipose tissue (eWAT). Neutralization with an anti-C87A antibody effectively reduced NET formation and downregulated key inflammatory chemokines, including CXCL1 and CXCL2, which are critical for recruiting neutrophils via the CXCR4 chemokine receptor. Enhanced signalling through CXCR4 was observed in the presence of elevated C87A, correlating with increased neutrophil infiltration and NETosis, suggesting a direct link between lipocalin-2 variants and the regulation of neutrophil activity in inflammatory conditions.Furthermore, we assessed the pathogenic role of C87A in models of obesity-induced hypertension and heart failure with preserved ejection fraction (HFpEF). Our results showed that modulation of C87A not only decreased neutrophil infiltration and NETosis but also mitigated the associated cardiovascular complications. Additionally, macrophage polarization was found to be protective against C87A-induced inflammation, while astrocytes in the brain contributed to obesity-induced hypertension through the paracrine release of inflammatory factors, including lipocalin-2.These findings highlight the complex interplay between lipocalin-2 variants, NETs, and inflammation, suggesting that targeting lipocalin-2 variant C87A may represent a novel therapeutic strategy to mitigate chronic inflammatory conditions and their cardiovascular complications. This research underscores the importance of understanding the mechanisms underlying NETs formation and the potential for lipocalin-2 variants as therapeutic targets in managing obesity-related cardiovascular diseases.
DOI: 10.15468/dl.wh955d
title: Occurrence Download

description: A dataset containing 642 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Eunectes notaeus Cope, 1862"
 ]
}

 The dataset includes 642 records from 50 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0001349-241107131044228/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.25442/hku.27302238
title: Supporting data for Investigation on the Virological Characteristics of SARS-CoV-2 Omicron

description: Since the emergence of Omicron subvariants, the BA.1, BA.2, and BA.5 lineages and their related sublineages have been implicated in most infections. Although there is evidence that all Omicron sublineages can significantly evade the neutralizing antibody response, it is still unknown if these subvariants share evolutionary patterns with regard to their replication fitness and pathogenicity.In this work, we examined Omicron's virological characteristics by assessing TMPRSS2 usage, spike cleavage, cell-cell fusion, and virus replication and pathogenicity in virto and in vivo. We found that Omicron BA.1 is attenuated compared to ancestral WT and Delta strains in lung tissues of K18-hACE2 mice, and BA.2 is similarly attenuated compared to BA.1. Our data also indicates that BA.5 has replication advantages in the human nasal epithelium and followed by the BA.1 and BA.2.Consistently, BA.5 infected K18-hACE2 mice produce more infectious viral particles in the nasal turbinate. In sharp contrast, omicron sublineages continue to be less pathogenic than the lungs of K18-hACE2 and C57BL/6 mice.To investigate viral determinants of increased fitness of Omicron in the human nasal epithelium,we constructed infectious clones of WT and BA.1 by reverse genetics and found that spike defines the replication advantages of Omicron BA.1 in the nasal epithelium;RBD and SD domains are the minimal factors to contribute to this phenotype. Our study suggested that the Omicron subvariant has gained intrinsic replication fitness in the upper respiratory tract; however, the pathogenicity of Omciron is less severe in the lower respiratory tract. Immunocompromised individuals should be vaccinated and receive other treatments to prohibit serious illness caused by SARS-CoV-2 infection.My dataset contains the raw data of three chapters, each of which is in a separate folder. Within each folder, there are additional subfolders containing the Prism data and images from immunofluorescence. The Prism data and immunofluorescence data correspond directly to the figures in the paper.
DOI: 10.25442/hku.27302238.v1
title: Supporting data for Investigation on the Virological Characteristics of SARS-CoV-2 Omicron

description: Since the emergence of Omicron subvariants, the BA.1, BA.2, and BA.5 lineages and their related sublineages have been implicated in most infections. Although there is evidence that all Omicron sublineages can significantly evade the neutralizing antibody response, it is still unknown if these subvariants share evolutionary patterns with regard to their replication fitness and pathogenicity.In this work, we examined Omicron's virological characteristics by assessing TMPRSS2 usage, spike cleavage, cell-cell fusion, and virus replication and pathogenicity in virto and in vivo. We found that Omicron BA.1 is attenuated compared to ancestral WT and Delta strains in lung tissues of K18-hACE2 mice, and BA.2 is similarly attenuated compared to BA.1. Our data also indicates that BA.5 has replication advantages in the human nasal epithelium and followed by the BA.1 and BA.2.Consistently, BA.5 infected K18-hACE2 mice produce more infectious viral particles in the nasal turbinate. In sharp contrast, omicron sublineages continue to be less pathogenic than the lungs of K18-hACE2 and C57BL/6 mice.To investigate viral determinants of increased fitness of Omicron in the human nasal epithelium,we constructed infectious clones of WT and BA.1 by reverse genetics and found that spike defines the replication advantages of Omicron BA.1 in the nasal epithelium;RBD and SD domains are the minimal factors to contribute to this phenotype. Our study suggested that the Omicron subvariant has gained intrinsic replication fitness in the upper respiratory tract; however, the pathogenicity of Omciron is less severe in the lower respiratory tract. Immunocompromised individuals should be vaccinated and receive other treatments to prohibit serious illness caused by SARS-CoV-2 infection.My dataset contains the raw data of three chapters, each of which is in a separate folder. Within each folder, there are additional subfolders containing the Prism data and images from immunofluorescence. The Prism data and immunofluorescence data correspond directly to the figures in the paper.
DOI: 10.15468/dl.wbhs8k
title: Occurrence Download

description: A dataset containing 3022 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is Colombia",
 "TaxonKey is one of (Aedes aegypti (Linnaeus, 1762), Euglossa imperialis Cockerell, 1922)"
 ]
}

 The dataset includes 3022 records from 20 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0001350-241107131044228/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.25442/hku.27300882
title: Supporting Data for Synthesis and Catalytic Studies of Copper(I) Complexes Coordinated by Catenane and Rotaxane Ligands

description: Catenane and rotaxane are representative classes of mechanically interlocked molecules (MIMs) consisting of physically entangled components in non-trivial topologies. The interlocked components held by mechanical bonds can undergo co-conformational motions with respect to each other, which are characteristic to MIMs and their unique chemistry. The application of MIMs as coordination ligand for metal-based catalysis has gained interest in rotaxanes but remained very limited for catenanes. The interlocked ligands offered a way to modify the metal coordination properties, enabling new potentials in catalysis showing different reactivity and selectivity. and applications of transition metal catenane complexes in catalysis are yet to be explored. In this thesis, the research will focus on developing new Cu(I)-based MIMs including post-synthetic modifications to modify physical properties and investigating catalytic activity in carbon–carbon bond formation reaction.<br>