cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.17632/v45hr8x8cj.4
title: Supplemental Material: Tolerability and Efficacy of Unorthodox Dosing Regimens of Tofacitinib and Baricitinib in Pediatric Patients with Moderate to Severe Alopecia Areata

description: 1. Research Hypothesis
This study tested the core hypothesis: over a 24-week treatment period, tofacitinib and baricitinib, administered via unorthodox weight-stratified dosing regimens, would exhibit comparable efficacy and tolerability in pediatric patients aged 2–17 years with moderate-to-severe AA.
2. Notable Findings
2.1 Comparable Overall Efficacy with Subtle Differences
Over 24 weeks, the two drugs showed no significant differences in primary efficacy endpoints (all P&gt;0.05), supporting the hypothesis of comparable efficacy under unorthodox dosing. 
2.2 Favorable Tolerability with Pediatric-Specific AE Profiles
Both drugs were well-tolerated in pediatric patients, with no serious AEs and low discontinuation rates. 
2.3 Limitations of Unorthodox Dosing for Baricitinib
The unorthodox BID regimen for baricitinib (2 mg BID) resulted in a lower SALT ≤20 response rate in severe AA (30.77%) compared to the guideline-recommended 4 mg QD regimen (67.7% in literature). This suggests that deviating from guideline dosing may reduce efficacy, likely due to subtherapeutic peak drug concentrations from BID administration, which limits suppression of follicular inflammation.
3. Data Interpretation
3.1 Efficacy: Applicability and Limitations of Unorthodox Dosing
Applicable scenarios: Unorthodox weight-stratified dosing can serve as a short-term (24-week) alternative for pediatric patients who cannot tolerate guideline-recommended doses (e.g., baricitinib 4 mg QD) or require matched dosing frequencies. Tofacitinib may be preferred for patients targeting "significant hair regrowth" (SALT 70 response), while baricitinib could be considered for those pursuing "near-complete regrowth" (given its numerical advantage in SALT 90 response).
Limitations: The reduced efficacy of baricitinib’s unorthodox regimen highlights the priority of guideline-recommended dosing. Unorthodox dosing should only be used in special cases (e.g., poor tolerability in young children) and requires therapeutic drug monitoring (TDM) to adjust doses, ensuring trough concentrations match those of guideline regimens.
3.2 Safety: Risk Profile and Monitoring Priorities
Risk profile: Short-term use of both JAK inhibitors is safe in children, with mild, manageable AEs (acne, transient hepatic enzyme elevations) and no increased risk of serious infections or cardiovascular events. Hematological AEs are less common in children than in adults, reducing concerns about blood-related safety risks.
Monitoring focus: Clinicians should monitor acne in pubertal patients, conduct regular tests for hepatic enzymes, lipids, and creatine kinase (especially in the baricitinib group), and educate caregivers on recognizing mild AEs (e.g., upper respiratory tract infections).
This dataset contains supplemental protocol, 1 supplemental figure, and 1 supplemental table.
DOI: 10.17632/3dh59pp7t3
title: Implementing a GRAFCET following Standard IEC-60848 in an ESP32 or STM32

description: Project in C++ with a template and different examples to codify in an ESP32 a Grafcet that follows the specifications of IEC 60848. It uses Visual Studio Code + PlatformIO
DOI: 10.17632/3dh59pp7t3.2
title: Implementing a GRAFCET following Standard IEC-60848 in an ESP32 or STM32

description: Project in C++ with a template and different examples to codify in an ESP32 a Grafcet that follows the specifications of IEC 60848. It uses Visual Studio Code + PlatformIO
DOI: 10.17632/gp2vrt26cx.2
title: DED-Surface Feature Sample Catalogue

description: In this dataset, a comprehensive collection of examples of structured feature assessment of real-world workpieces manufactured by directed energy deposition is presented. The examples supplement a tabular technical specification of surface features with visual topology appearances. For more details on source, context and interpretation of the data see research article "Structured approach towards surface feature classification on DED-printed parts" in the related link. Samples #24 … #30 courtesy of GEFERTEC, Berlin.
DOI: 10.17632/z2c84cmk7x
title: Metagenomic Analysis of Chicks in the High-Dose Group

description: Zearalenone (ZEN), a prevalent mycotoxin produced by fungi of the genus Fusarium, poses significant health risks to animals and humans via contaminated food chains. Despite its recognized toxicity, the transgenerational effects of embryonic egg ZEN exposure on avian development and subsequent chick health remain poorly understood. In this study, embryonic egg injection technology and multi-omics approach were used to investigate the effects of embryonic egg injection of ZEN on hatching performance, post-hatch growth, and physiological health in chicks. A total of 480 Hy-line Brown embryonic eggs were administered varying ZEN doses (0, 5, 50, 500 μg/egg) on day 5 of incubation. ZEN exposure significantly reduced hatchability and initial weight, with dose-dependent decreases in net weight, average daily gain, and average daily feed intake, and an increase in feed conversion ratio at 20 days post-hatch. Histological analysis revealed intestinal inflammation and structural damage, accompanied by gut microbiota dysbiosis, characterized by increased abundance of pathogenic bacteria such as Escherichia coli. ZEN exposure also induced liver damage, evidenced by elevated serum biochemical markers, oxidative stress, and inflammatory responses. Metabolomic profiling indicated significant alterations in hepatic metabolites and metabolic pathways related to lipid metabolism, autophagy, and antioxidant defense. In addition, Correlation analysis suggested that gut microbiota dysbiosis and hepatic metabolic disorders are interconnected, potentially mediating ZEN-induced toxicity via the gut-liver axis. These findings provide novel insights into the mechanisms underlying ZEN's developmental toxicity and highlight the importance of mitigating ZEN contamination in poultry farming.
DOI: 10.17632/z2c84cmk7x.1
title: Metagenomic Analysis of Chicks in the High-Dose Group

description: Zearalenone (ZEN), a prevalent mycotoxin produced by fungi of the genus Fusarium, poses significant health risks to animals and humans via contaminated food chains. Despite its recognized toxicity, the transgenerational effects of embryonic egg ZEN exposure on avian development and subsequent chick health remain poorly understood. In this study, embryonic egg injection technology and multi-omics approach were used to investigate the effects of embryonic egg injection of ZEN on hatching performance, post-hatch growth, and physiological health in chicks. A total of 480 Hy-line Brown embryonic eggs were administered varying ZEN doses (0, 5, 50, 500 μg/egg) on day 5 of incubation. ZEN exposure significantly reduced hatchability and initial weight, with dose-dependent decreases in net weight, average daily gain, and average daily feed intake, and an increase in feed conversion ratio at 20 days post-hatch. Histological analysis revealed intestinal inflammation and structural damage, accompanied by gut microbiota dysbiosis, characterized by increased abundance of pathogenic bacteria such as Escherichia coli. ZEN exposure also induced liver damage, evidenced by elevated serum biochemical markers, oxidative stress, and inflammatory responses. Metabolomic profiling indicated significant alterations in hepatic metabolites and metabolic pathways related to lipid metabolism, autophagy, and antioxidant defense. In addition, Correlation analysis suggested that gut microbiota dysbiosis and hepatic metabolic disorders are interconnected, potentially mediating ZEN-induced toxicity via the gut-liver axis. These findings provide novel insights into the mechanisms underlying ZEN's developmental toxicity and highlight the importance of mitigating ZEN contamination in poultry farming.
DOI: 10.15468/dl.4mgv9r
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Cerebratulus tageae",
 "HasCoordinate is true",
 "HasGeospatialIssue is false"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0017633-251025141854904/datasets/export for details.
DOI: 10.17632/f9n5c6ktpy
title: Landslide Susceptibility Assessment in Huizhou, South China

description: Landslide Conditional Factors of Huizhou City: Elevation, Slope, Aspect, Curvature, Stream Power Index (SPI), Terrain Wetness Index (TWI), Normalized Difference Vegetation Index (NDVI), Normalized Difference Built-up Index (NDBI), Land Use, Precipitation, Distance to Road (DTR), Distance to Water (DTW), Distance to Fault (DTF).
DOI: 10.17632/f9n5c6ktpy.1
title: Landslide Susceptibility Assessment in Huizhou, South China

description: Landslide Conditional Factors of Huizhou City: Elevation, Slope, Aspect, Curvature, Stream Power Index (SPI), Terrain Wetness Index (TWI), Normalized Difference Vegetation Index (NDVI), Normalized Difference Built-up Index (NDBI), Land Use, Precipitation, Distance to Road (DTR), Distance to Water (DTW), Distance to Fault (DTF).
DOI: 10.17632/jf394xyb2m.4
title: Dataset on the Distortional Buckling Capacity of Cold-Formed Z-Sections with Stiffened Web: Experimental and Theoretical Studies

description: This dataset supports the investigation of the flexural behavior of cold-formed Z-purlins with stiffened webs, a recently developed cross-section designed to improve structural efficiency under bending. The research hypothesis is that the web stiffeners enhance the purlin’s resistance to local and distortional buckling, potentially increasing its flexural capacity beyond conventional Z-sections. The data include results from full-scale bending tests on isolated and lapped specimens, with measurements of load and displacement. The dataset also comprises theoretical predictions based on the Direct Strength Method (DSM) and Effective Width Method (EWM), following AISI S100:2016, AISI S100:2024, and EN 1993-1-3:2024 provisions. The comparison between experimental and predicted capacities highlights the influence of local–distortional buckling interaction and bending-shear interaction. This dataset can be used to calibrate numerical models, validate design procedures, or perform reliability studies for advanced cold-formed steel applications.
DOI: 10.17632/4vnv6dpnwn
title: A study of Akt2 Regulates Autophagy and Osteogenesis in Diabetic Osteoporosis via PI3K/AKT/mTOR Signaling Axis. QN Ye et al.

description: Original images of western blot in this paper.
DOI: 10.17632/4vnv6dpnwn.1
title: A study of Akt2 Regulates Autophagy and Osteogenesis in Diabetic Osteoporosis via PI3K/AKT/mTOR Signaling Axis. QN Ye et al.

description: Original images of western blot in this paper.
DOI: 10.17632/dcsnssyzm2
title: Fire Dynamics in the central Great Khingan Mountains

description: To explain the relationship between fire activity and climate change in the East Asian summer monsoon (EASM) marginal zone, this study presents a microcharcoal record from Lake Tuofengling, providing a 25.0 kyr reconstruction of fire history in Northeast China. Firstly, microcharcoal particles were divided into large grains (50-200 μm) and small grains (10-50 μm) according to the long axes of each grain. Meanwhile, length to width ratio (L:W) of the microcharcoal particles was applied to distinguish sub-long (&gt;2.5:1) from sub-round (&lt;2.5:1) microcharcoals.
DOI: 10.17632/dcsnssyzm2.1
title: Fire Dynamics in the central Great Khingan Mountains

description: To explain the relationship between fire activity and climate change in the East Asian summer monsoon (EASM) marginal zone, this study presents a microcharcoal record from Lake Tuofengling, providing a 25.0 kyr reconstruction of fire history in Northeast China. Firstly, microcharcoal particles were divided into large grains (50-200 μm) and small grains (10-50 μm) according to the long axes of each grain. Meanwhile, length to width ratio (L:W) of the microcharcoal particles was applied to distinguish sub-long (&gt;2.5:1) from sub-round (&lt;2.5:1) microcharcoals.
DOI: 10.17632/54g89267pf
title: Data Set on Learning Outcomes and Interests of Prospective Teachers in Office Administration: Trial of VR-Based Learning in Non-STEM Fields

description: This data set was used in this study, which aimed to investigate the effectiveness of VR in improving learning outcomes and interest among prospective office administration teachers (PST-OA). The study was conducted in Indonesia with 62 participants and 2 evaluators. The personal identities of the participants and evaluators have been removed to protect their privacy.
DOI: 10.17632/54g89267pf.1
title: Data Set on Learning Outcomes and Interests of Prospective Teachers in Office Administration: Trial of VR-Based Learning in Non-STEM Fields

description: This data set was used in this study, which aimed to investigate the effectiveness of VR in improving learning outcomes and interest among prospective office administration teachers (PST-OA). The study was conducted in Indonesia with 62 participants and 2 evaluators. The personal identities of the participants and evaluators have been removed to protect their privacy.
DOI: 10.17632/gcmxns5nmk.2
title: Absolute and adjusted carbon emissions data of European energy and heavy-industry sectors

description: The dataset includes data on absolute and adjusted carbon emissions (i.e., total, per capita, and per unit of industrial gross value added) from energy and heavy-industry sectors in 238 regions across 27 EU countries over a 13-year period (2008–2020).
DOI: 10.17632/n8szyggzm7
title: Doctoral Research Dataset

description: Details about our qualitative research performed in my doctoral research. The study conducted 18 semi-structured interviews with project managers, software engineers, designers, and testers to perform deep interpretive analyses aiming to understand their experiences and challenges in software development contracting stage at CESAR, a leading Brazilian Institute of Science and Technology focused on software-driven innovation projects. The dataset includes research questions, guide interview versions, prompts submitted to some AI-assisted tool (chatGPT, Manus, Gemini) in order to make some qualitative analysis activities like refining interview guide, transcription of audio interview, coding identification over transcription, text translation and revision, etc. Due to the sensitive nature of the questions asked in this study, semi-structured interviews respondents were assured raw data would remain confidential and would not be shared.
DOI: 10.17632/n8szyggzm7.2
title: Doctoral Research Dataset

description: Details about our qualitative research performed in my doctoral research. The study conducted 18 semi-structured interviews with project managers, software engineers, designers, and testers to perform deep interpretive analyses aiming to understand their experiences and challenges in software development contracting stage at CESAR, a leading Brazilian Institute of Science and Technology focused on software-driven innovation projects. The dataset includes research questions, guide interview versions, prompts submitted to some AI-assisted tool (chatGPT, Manus, Gemini) in order to make some qualitative analysis activities like refining interview guide, transcription of audio interview, coding identification over transcription, text translation and revision, etc. Due to the sensitive nature of the questions asked in this study, semi-structured interviews respondents were assured raw data would remain confidential and would not be shared.
DOI: 10.15468/dl.ab2jzh
title: Occurrence Download

description: A dataset containing 151810 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Erica cinerea",
 "HasCoordinate is true"
 ]
}

 The dataset includes 151810 records from 1120 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0017564-251025141854904/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.h9asby
title: Occurrence Download

description: A dataset containing 22 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Phyteuma scheuchzeri",
 "Country is United Kingdom of Great Britain and Northern Ireland",
 "HasCoordinate is true"
 ]
}

 The dataset includes 22 records from 6 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0009482-251009101135966/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.uve28q
title: Occurrence Download

description: A dataset containing 501 species occurrences available in GBIF matching the query:
{
 "DatasetKey" : [
 "is Occurrence records of small and medium sized mammal species in Tana River Basin, Kenya"
 ]
}

 The dataset includes 501 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0009483-251009101135966/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.5281/zenodo.15252655
title: anser_albifrons_zanfona_1.fasta.gz
DOI: 10.5281/zenodo.15252656
title: anser_albifrons_zanfona_1.fasta.gz
DOI: 10.57907/mirri/bjbx9e/yitkr1
title: MIRRI0069892.json

description: Strain json file
DOI: 10.57907/mirri/calibe
title: MIRRI0069918

description: Organism type: Filamentous Fungi ; Taxon name: Oidiodendron maius ; Collection: CBS 110450 ; Country: Netherlands
DOI: 10.57907/mirri/cnh5fs/4gka2z
title: MIRRI0069951.json

description: Strain json file
DOI: 10.57907/mirri/d0ijnj/kaiyoz
title: MIRRI0069718.json

description: Strain json file
DOI: 10.57907/mirri/e16avo/7d5zer
title: MIRRI0069870.json

description: Strain json file
DOI: 10.57907/mirri/fsspk3/alhw4j
title: MIRRI0069923.json

description: Strain json file
DOI: 10.57907/mirri/fsvhtt/kb1pxw
title: MIRRI0069963.json

description: Strain json file
DOI: 10.57907/mirri/gjzdsl/fhpztx
title: MIRRI0069836.json

description: Strain json file
DOI: 10.57907/mirri/hoouqi/2k6dx5
title: MIRRI0069899.json

description: Strain json file
DOI: 10.57907/mirri/opphsf
title: MIRRI0069854

description: Organism type: Filamentous Fungi ; Taxon name: Phaeoacremonium krajdenii ; Collection: CBS 110368 ; Country: United States of America
DOI: 10.57907/mirri/oqctj4/bejavq
title: MIRRI0069902.json

description: Strain json file
DOI: 10.57907/mirri/oyuf6d
title: MIRRI0069901

description: Organism type: Filamentous Fungi ; Taxon name: Penicillium dipodomyicola ; Collection: CBS 110427 ; Country: United States of America
DOI: 10.57907/mirri/oyuf6d/e8zmdc
title: MIRRI0069901.json

description: Strain json file
DOI: 10.57907/mirri/wyxqym
title: MIRRI0069873

description: Organism type: Filamentous Fungi ; Taxon name: Purpureocillium lilacinum ; Collection: CBS 110398 ; Country: Canada
DOI: 10.57907/mirri/xycc1e
title: MIRRI0069921

description: Organism type: Filamentous Fungi ; Taxon name: Talaromyces thermophilus ; Collection: CBS 110455 ; Country: United States of America
DOI: 10.3535/6qb-vl3-m8b
title: Thymelaea passerina (L.) Coss. & Germ.

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/h0k-vxk-2yg
title: Globularia cordifolia L.

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.57907/mirri/b0nwf6/rrm37f
title: MIRRI0069909.json

description: Strain json file
DOI: 10.57907/mirri/fhok16
title: MIRRI0069935

description: Organism type: Filamentous Fungi ; Taxon name: Coniochaeta malacotricha ; Collection: CBS 110470 ; Country: Germany
DOI: 10.57907/mirri/hl8mqm/1nqjgs
title: MIRRI0069927.json

description: Strain json file
DOI: 10.57907/mirri/ix39x0/0xxvxz
title: MIRRI0069894.json

description: Strain json file
DOI: 10.57907/mirri/j29oc0/zmscje
title: MIRRI0069924.json

description: Strain json file
DOI: 10.57907/mirri/mkfio4/n8n8og
title: MIRRI0069735.json

description: Strain json file
DOI: 10.57907/mirri/njvdee
title: MIRRI0069721

description: Organism type: Filamentous Fungi ; Taxon name: Nalanthamala psidii ; Collection: CBS 110185 ; Country: South Africa
DOI: 10.57907/mirri/oqctj4
title: MIRRI0069902

description: Organism type: Filamentous Fungi ; Taxon name: Paecilomyces divaricatus ; Collection: CBS 110429 ; Country: Mexico
DOI: 10.57907/mirri/slrck8
title: MIRRI0069737

description: Organism type: Filamentous Fungi ; Taxon name: Verticillium longisporum ; Collection: CBS 110220 ; Country: Sweden
DOI: 10.57907/mirri/tlffpj/aoicey
title: MIRRI0069925.json

description: Strain json file
DOI: 10.57907/mirri/ufz4br/t1daxk
title: MIRRI0069732.json

description: Strain json file
DOI: 10.3535/cld-q4h-k10
title: Luzula plumosa E. Mey.

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/skp-6r6-1l6
title: Veronica catenata Pennell

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.57907/mirri/dz1cfw/0itar7
title: MIRRI0069928.json

description: Strain json file
DOI: 10.57907/mirri/t8rqut
title: MIRRI0070016

description: Organism type: Filamentous Fungi ; Taxon name: Wallemia sebi ; Collection: CBS 110594
DOI: 10.3535/x3v-h2g-g2v
title: Pilosella densiflora subsp. ochrocephaloides (K. Harz & Zahn) Gottschl.

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.57907/mirri/3p5foe/jpmszy
title: MIRRI0069910.json

description: Strain json file
DOI: 10.57907/mirri/5f8cwv
title: MIRRI0069950

description: Organism type: Filamentous Fungi ; Taxon name: Devonomyces endophyticus ; Collection: CBS 110501 ; Country: Australia
DOI: 10.57907/mirri/5h6ua2/42qgfn
title: MIRRI0069961.json

description: Strain json file
DOI: 10.57907/mirri/6ceucg
title: MIRRI0069890

description: Organism type: Filamentous Fungi ; Taxon name: Penicillium griseofulvum ; Collection: CBS 110416 ; Country: South Africa
DOI: 10.57907/mirri/6fjgs5
title: MIRRI0069893

description: Organism type: Filamentous Fungi ; Taxon name: Penicillium griseofulvum ; Collection: CBS 110419 ; Country: Canada
DOI: 10.57907/mirri/aeorgx/ojmfyk
title: MIRRI0069761.json

description: Strain json file
DOI: 10.57907/mirri/ajzwwf
title: MIRRI0069880

description: Organism type: Filamentous Fungi ; Taxon name: Penicillium flavigenum ; Collection: CBS 110406 ; Country: United States of America
DOI: 10.57907/mirri/b0nwf6
title: MIRRI0069909

description: Organism type: Filamentous Fungi ; Taxon name: Umbelopsis ramanniana ; Collection: CBS 110439 ; Country: Netherlands
DOI: 10.57907/mirri/bdca1p
title: MIRRI0069979

description: Organism type: Filamentous Fungi ; Taxon name: Phytophthora ramorum ; Collection: CBS 110542 ; Country: United States of America
DOI: 10.57907/mirri/gaifhu/umctbv
title: MIRRI0069876.json

description: Strain json file
DOI: 10.57907/mirri/gcbp5m/efaztx
title: MIRRI0069947.json

description: Strain json file
DOI: 10.57907/mirri/hoouqi
title: MIRRI0069899

description: Organism type: Filamentous Fungi ; Taxon name: Penicillium dipodomyicola ; Collection: CBS 110425 ; Country: United States of America
DOI: 10.57907/mirri/jsiq9e/eob6vp
title: MIRRI0069878.json

description: Strain json file
DOI: 10.57907/mirri/m4j6cn
title: MIRRI0069912

description: Organism type: Filamentous Fungi ; Taxon name: Lignincola laevis ; Collection: CBS 110443 ; Country: Hong Kong
DOI: 10.57907/mirri/m4j6cn/edghv5
title: MIRRI0069912.json

description: Strain json file
DOI: 10.57907/mirri/m6mh8c
title: MIRRI0069994

description: Organism type: Filamentous Fungi ; Taxon name: Fusarium culmorum ; Collection: CBS 110566 ; Country: France
DOI: 10.57907/mirri/mhahrh
title: MIRRI0069937

description: Organism type: Filamentous Fungi ; Taxon name: Coniochaeta velutina ; Collection: CBS 110472 ; Country: Germany
DOI: 10.57907/mirri/mub4fp/bvzepp
title: MIRRI0069747.json

description: Strain json file