cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.17608/k6.auckland.5611168
title: cruising speed of flight versus weight

description: A collection of data on flying objects, from the book by henk tennekes<br>
DOI: 10.6084/m9.figshare.5611255.v3
title: Short-term gains in histology knowledge: A veterinary gaming application

description: Data set used in manuscript, "Short-term gains in histology knowledge: A veterinary gaming application"
DOI: 10.6084/m9.figshare.5611255.v2
title: Short-term gains in histology knowledge: A veterinary gamingaapplication

description: Data set used in manuscript, "Short-term gains in histology knowledge: A veterinary gaming application"
DOI: 10.6084/m9.figshare.5607841
title: Machine Learning approach to rupture dynamics

description: The deformation-related energy budget is usually considered in the simplest form or even completely omitted from the energy balance equation. We derive a full energy balance equation that accounts not only for heat energy but also for mechanical (elastic, plastic and viscous) work. The derived equation is implemented in DES3D, an unstructured finite element solver for long-term tectonic deformation. We verify the implementation by comparing numerical solutions to the corresponding semi-analytic solutions in three benchmarks extended from the classical oedometer test. Two of the benchmarks are designed to evaluate the temperature change in a Mohr-Coulomb elasto-plastic square governed by a simplified equation involving plastic power only and by the full temperature evolution equation, respectively. The third benchmark differs in that it computes thermal stresses associated with a prescribed uniform temperature increase. All the solutions from DES3D show relative errors less than 0.1 \%. We also investigate the long-term effects of deformation energetics on the evolution of large offset normal faults.We find that the models considering the full energy balance equation tend to produce more secondary faults and an elongated core complex. Our results for the normal fault system confirm that persistent inelastic deformation has significant impact on the long-term evolution of faults, motivating further exploration of the role of the full energy balance equation in other geodynamic systems.
DOI: 10.6084/m9.figshare.5607637
title: Supplementary Material for: Palmitic Acid Curcumin Ester Facilitates Protection of Neuroblastoma against Oligomeric Aβ<sub>40</sub> Insult

description: <b><i>Background/Aims:</i></b> The generation of reactive oxygen species (ROS) caused by amyloid-β (Aβ) is considered to be one of mechanisms underlying the development of Alzheimer’s disease. Curcumin can attenuate Aβ-induced neurotoxicity through ROS scavenging, but the protective effect of intracellular curcumin on neurocyte membranes against extracellular Aβ may be compromised. To address this issue, we synthesized a palmitic acid curcumin ester (P-curcumin) which can be cultivated on the cell membrane and investigated the neuroprotective effect of P-curcumin and its interaction with Aβ. <b><i>Methods:</i></b> P-curcumin was prepared through chemical synthesis. Its structure was determined via nuclear magnetic resonance (NMR) and high-resolution mass spectrometry (HRMS). An MTT assay was used to assess Aβ cytotoxicity and the protective effect of P-curcumin on SH-SY5Y cells. The effect of P-curcumin on Aβ-induced ROS production <i>in vitro</i> and <i>in vivo</i> were assessed based on changes in dichlorofluorescein (DCF) fluorescence. A spectrophotometric method was employed to detect lipid peroxidation. To mimic the interaction of P-curcumin on cell membranes with Aβ, liposomes were prepared by thin film method. Finally, the interactions between free P-curcumin and P-curcumin cultivated on liposomes and Aβ were determined via spectrophotometry. <b><i>Results:</i></b> A novel derivative, palmitic acid curcumin ester was prepared and characterized. This curcumin, cultivated on the membranes of neurocytes, may prevent Aβ-mediated ROS production and may inhibit the direct interaction between Aβ and the cellular membrane. Furthermore, P-curcumin could scavenge Aβ-mediated ROS as curcumin <i>in vitro</i> and <i>in vivo</i>, and had the potential to prevent lipid peroxidation. Morphological analyses showed that P-curcumin was better than curcumin at protecting cell shape. To examine P-curcumin’s ability to attenuate direct interaction between Aβ and cell membranes, the binding affinity of Aβ to curcumin and P-curcumin was determined. The association constants for free P-curcumin and curcumin were 7.66 × 10<sup>4</sup> M<sup>-1</sup> and 7.61 × 10<sup>5</sup> M<sup>-1</sup>, respectively. In the liposome-trapped state, the association constants were 3.71 × 10<sup>5</sup> M<sup>-1</sup> for P-curcumin and 1.44× 10<sup>6</sup> M<sup>-1</sup> for curcumin. With this data, the thermodynamic constants of P-curcumin association with soluble Aβ <i>(ΔH, ΔS</i>, and Δ<i>G</i>) were also determined. <b><i>Conclusion:</i></b> Cultivated curcumin weakened the direct interaction between Aβ and cell membranes and showed greater neuroprotective effects against Aβ insult than free curcumin.
DOI: 10.6084/m9.figshare.5607634
title: submission_revision.xlsx

description: Gathered results for calcium volume scores on two phantoms and clinical subjects acquired using clinical calcium score and partial volume corrected scores used in manuscript "Coronary calcium scoring with partial volume correction in anthropomorphic thorax phantom and screening chest CT images" submitted at PLOS ONE.
DOI: 10.6084/m9.figshare.5607565
title: Data and R code supplement to "Tree canopy change in Coastal Los Angeles, 2009 - 2014"

description: This file set accompanies this paper: <br>Locke, D.H., Romolini, R., Galvin, M. F., O’Neil-Dunne, J. P. M., Strauss, E. G.. (2017). Tree canopy change in Coastal Los Angeles, 2009 - 2014. Cities And The Environment (CATE) http://digitalcommons.lmu.edu/cate/vol10/iss2/3<br>The files contain a Census block group shapefile and a parcel .*dbf (1.2 GB). The parcel polygons were not provided to keep the file size manageable. Contact me if you would like the polygons to accompany the tabular parcel data. <br>This script replicates the analyses contained in the paper. Additional data and analyses are provided, by only those appearing in the paper are documented in the script.
DOI: 10.6084/m9.figshare.5607580
title: Estimación de voto/Resultados Metroscopia con Podemos (más Confluencias)

description: Estimación/Resultados en Metroscopia con Podemos (+Confluencias)<br>
DOI: 10.6084/m9.figshare.5607565.v2
title: Data and R code supplement to "Tree canopy change in Coastal Los Angeles, 2009 - 2014"

description: This file set accompanies this paper: <br>Locke, D.H., Romolini, R., Galvin, M. F., O’Neil-Dunne, J. P. M., Strauss, E. G.. (2017). Tree canopy change in Coastal Los Angeles, 2009 - 2014. Cities And The Environment (CATE) http://digitalcommons.lmu.edu/cate/vol10/iss2/3<br>The files contain a Census block group shapefile and a parcel .*dbf (1.2 GB). The parcel polygons were not provided to keep the file size manageable. Contact me if you would like the polygons to accompany the tabular parcel data. <br>This script replicates the analyses contained in the paper. Additional data and analyses are provided, by only those appearing in the paper are documented in the script.
DOI: 10.6084/m9.figshare.5607580.v1
title: Estimación de voto/Resultados Metroscopia con Podemos (más Confluencias)

description: Estimación/Resultados en Metroscopia con Podemos (+Confluencias)<br>
DOI: 10.6084/m9.figshare.5607565.v1
title: Data and R code supplement to "Tree canopy change in Coastal Los Angeles, 2009 - 2014"

description: This file set accompanies this paper: <br>Locke, D.H., Romolini, R., Galvin, M. F., O’Neil-Dunne, J. P. M., Strauss, E. G.. (2017). Tree canopy change in Coastal Los Angeles, 2009 - 2014. Cities And The Environment (CATE) http://digitalcommons.lmu.edu/cate/vol10/iss2/3<br>The files contain a Census block group shapefile and a parcel .*dbf (1.2 GB). The parcel polygons were not provided to keep the file size manageable. Contact me if you would like the polygons to accompany the tabular parcel data. <br>This script replicates the analyses contained in the paper. Additional data and analyses are provided, by only those appearing in the paper are documented in the script.
DOI: 10.6084/m9.figshare.5607247
title: Supplementary Material for: Dietary Fructo-Oligosaccharides Attenuate Early Activation of CD4+ T Cells Which Produce both Th1 and Th2 Cytokines in the Intestinal Lymphoid Tissues of a Murine Food Allergy Model

description: <b><i>Background:</i></b> Fructo-oligosaccharides (FOS) are prebiotic agents with immunomodulatory effects involving improvement of the intestinal microbiota and metabolome. In this study, we investigated the cellular mechanisms through which FOS modulate intestinal antigen-specific CD4<sup>+</sup> T cell responses in food allergy, using OVA23-3 mice. <b><i>Methods:</i></b> OVA23-3 mice were fed an experimental diet containing either ovalbumin (OVA) or OVA and FOS for 1 week. Body weight and mucosal mast cell protease 1 in the serum were measured as the indicator of intestinal inflammation. Single-cell suspensions were prepared from intestinal and systemic lymphoid tissues for cellular analysis. Cytokine production was measured by ELISA. Activation markers and intracellular cytokines in CD4<sup>+</sup> T cells were analyzed by flow cytometry. Activated CD4<sup>+</sup> T cells were purified to examine cytokine production. <b><i>Results:</i></b> Dietary intake of FOS provided moderate protection from the intestinal inflammation induced by the OVA-containing diet. FOS significantly reduced food allergy-induced Th2 cytokine responses in intestinal tissues but not in systemic tissues. FOS decreased OVA diet-induced IFN-γ<sup>+</sup>IL-4<sup>+</sup> double-positive CD4<sup>+</sup> T cells and early-activated CD45RB<sup>high</sup>CD69<sup>+</sup>CD4<sup>+</sup> T cells in the mesenteric lymph nodes. Furthermore, we confirmed that these CD45RB<sup>high</sup>CD69<sup>+</sup>CD4<sup>+</sup> T cells are able to produce high levels of IFN-γ and moderate level of IL-4, IL-10, and IL-13. <b><i>Conclusions:</i></b> Dietary intake of FOS during the development of food allergy attenuates the induction of intestinal Th2 cytokine responses by regulating early activation of naïve CD4<sup>+</sup> T cells, which produce both Th1 and Th2 cytokines. Our results suggest FOS might be a potential food agent for the prevention of food allergy by modulating oral sensitization to food antigens.
DOI: 10.6084/m9.figshare.5607247.v1
title: Supplementary Material for: Dietary Fructo-Oligosaccharides Attenuate Early Activation of CD4+ T Cells Which Produce both Th1 and Th2 Cytokines in the Intestinal Lymphoid Tissues of a Murine Food Allergy Model

description: <b><i>Background:</i></b> Fructo-oligosaccharides (FOS) are prebiotic agents with immunomodulatory effects involving improvement of the intestinal microbiota and metabolome. In this study, we investigated the cellular mechanisms through which FOS modulate intestinal antigen-specific CD4<sup>+</sup> T cell responses in food allergy, using OVA23-3 mice. <b><i>Methods:</i></b> OVA23-3 mice were fed an experimental diet containing either ovalbumin (OVA) or OVA and FOS for 1 week. Body weight and mucosal mast cell protease 1 in the serum were measured as the indicator of intestinal inflammation. Single-cell suspensions were prepared from intestinal and systemic lymphoid tissues for cellular analysis. Cytokine production was measured by ELISA. Activation markers and intracellular cytokines in CD4<sup>+</sup> T cells were analyzed by flow cytometry. Activated CD4<sup>+</sup> T cells were purified to examine cytokine production. <b><i>Results:</i></b> Dietary intake of FOS provided moderate protection from the intestinal inflammation induced by the OVA-containing diet. FOS significantly reduced food allergy-induced Th2 cytokine responses in intestinal tissues but not in systemic tissues. FOS decreased OVA diet-induced IFN-γ<sup>+</sup>IL-4<sup>+</sup> double-positive CD4<sup>+</sup> T cells and early-activated CD45RB<sup>high</sup>CD69<sup>+</sup>CD4<sup>+</sup> T cells in the mesenteric lymph nodes. Furthermore, we confirmed that these CD45RB<sup>high</sup>CD69<sup>+</sup>CD4<sup>+</sup> T cells are able to produce high levels of IFN-γ and moderate level of IL-4, IL-10, and IL-13. <b><i>Conclusions:</i></b> Dietary intake of FOS during the development of food allergy attenuates the induction of intestinal Th2 cytokine responses by regulating early activation of naïve CD4<sup>+</sup> T cells, which produce both Th1 and Th2 cytokines. Our results suggest FOS might be a potential food agent for the prevention of food allergy by modulating oral sensitization to food antigens.
DOI: 10.6084/m9.figshare.5607232
title: Supplementary Material for: GSK3α/β: A Novel Therapeutic Target for Neuroendocrine Tumors?

description: <b><i>Introduction:</i></b> Glycogen synthase kinase 3α/β (GSK3α/β) is a serine/threonine kinase that plays a critical role in cancer. <b><i>Aims:</i></b> In this study, we evaluated the effects of the specific GSK3α/β inhibitor AR-A014418 in vitro to gain novel insights into GSK3α/β signaling in neuroendocrine tumors (NETs). <b><i>Materials and Methods:</i></b> Human NET cell lines (BON1, QGP1, H727, and GOT1) were treated with different concentrations of AR-A014418 alone and in combination with lovastatin, everolimus, 5-fluorouracil (5-FU), and γ-irradiation. <b><i>Results:</i></b> AR-A014418 significantly dose- and time-dependently decreased cell viability in all 4 NET cell lines through inhibition of epithelial growth factor receptor and mTORC1/p70S6K signaling, as well as cyclin D3 downregulation and induction of pChk1. In all cell lines tested, FACS analysis showed an AR-A014418-induced increase in the sub-G1 phase, reflecting cell death. Apoptosis induction was observed in H727, GOT1 and QGP1 cells, but not in BON1 cells. Furthermore, significant antimigratory effects upon GSK3α/β inhibition were found and were associated with β-catenin downregulation in all cell lines tested. Compensatory upregulation of pAkt and pERK in response to GSK3α/β inhibition was prevented by combining AR-A014418 with the ERK and Akt inhibitor lovastatin. Accordingly, the lovastatin/AR-A014418 combination was synergistic in BON1 and QGP1 cells. Moreover, AR-A014418 displayed promising chemosensitizing effects on 5-FU in QGP1 and slight radiosensitizing properties in BON1 and QGP1 cells. <b><i>Conclusion:</i></b> Our data provide new insights into the role of GSK3α/β in NETs and suggest that GSK3α/β inhibition could be a novel therapeutic option in NETs, especially in combination with lovastatin or 5-FU, depending on tumor entity.
DOI: 10.6084/m9.figshare.5607160
title: Seismic interpretation of sill complexes in sedimentary basins: implications for the sub-sill imaging problem

description: This is a supplement to the paper "Seismic interpretation of Sill-Complexes in Sedimentary Basins: Implications for the Sub-Sill Imaging Problem" by "Christian Haug Eide, Nick Schofield, Isabelle Lecomte, Simon J. Buckley and John A. Howell*published in the "Journal of the Geological Society", published in 2018.<br><br>DOI of peer-reviewed paper: https://doi.org/10.1144/jgs2017-096,DOI to publically available preprint: https://dx.doi.org/10.17605/OSF.IO/JFS9X<br><br>*If you use any of the files provided here, you should cite this paper.*<br><br>Description:The input model in this paper is provided here so that it can be used by anyone who would like a complex geological model to test numerical geophysical methods. It shows Jurassic siliciclastic rocks intruded by a mafic sill complex. It is particularly interesting because of the complex shape of the sill complex, and because of the strong difference in density and acoustic velocity between sedimentary rocks and intrusives.<br>Dimensions:The model is 21 198 m long and 414 m high. The resolution of the model is 3 m/pixel laterally, and 0.5 m vertically. <br>Contents: <br>A1: Input model to seismic modelling, presented in paper as Figure 5D. Extrapolated architectural model of the sill-bearing parts of the Hurry Inlet section. Each pixel is 3 m in horizontal extent and 0.5 m in vertical extent. The gray values correspont to the following facies associations (FA in Table 1): FA1 (igneous intrusions, 97), FA2 (homogeneous sandstone. 159), FA3 (Sandstone, 124), FA4 (Poorly cemented sandstone, 55), FA5 (Heterolithic, 130), FA6 (mudstone, 111), and FA7 (Organic rich mudstone, 0). <br>A2: Very high-resolution versions of panels on left side of Fig. 11, showing comments and synthetic seismograms overlain the outcrop model. <br>A3: Very high-resolution version of panels on right side of Fig. 11, showing A) outcrop; B) reflectivity model; C) synthetic seismogram generated with seismogram using a 40 Hz wavelet and 80° max dip; D) Synthetic seismogram generated with seismogram using a 20 Hz wavelet and 50° max dip; E) Synthetic seismogram generated with seismogram using a 15Hz wavelet and 30° max dip. F) Synthetic seismogram generated with seismogram using a 10 Hz wavelet and 30° max dip. PSF: Point-spread function.<br>A4: Text version of A1.<br>A5: Spreadsheet showing input values and gray values used in modelling. <br>
DOI: 10.6084/m9.figshare.5607157
title: Better Science through Better Data 2017 (#scidata17) - Lightning talk slides (session 2)

description: Slides from the second lightning talk session (Tools and policies for Open Research explored) from the Better Science through Better data 2017 (#scidata17) conference
DOI: 10.6084/m9.figshare.5607160.v2
title: Seismic interpretation of sill complexes in sedimentary basins: implications for the sub-sill imaging problem

description: This is a supplement to the paper "Seismic interpretation of Sill-Complexes in Sedimentary Basins: Implications for the Sub-Sill Imaging Problem" by "Christian Haug Eide, Nick Schofield, Isabelle Lecomte, Simon J. Buckley and John A. Howell*published in the "Journal of the Geological Society", published in 2018.<br><br>DOI of peer-reviewed paper: https://doi.org/10.1144/jgs2017-096,DOI to publically available preprint: https://dx.doi.org/10.17605/OSF.IO/JFS9X<br><br>*If you use any of the files provided here, you should cite this paper.*<br><br>Description:The input model in this paper is provided here so that it can be used by anyone who would like a complex geological model to test numerical geophysical methods. It shows Jurassic siliciclastic rocks intruded by a mafic sill complex. It is particularly interesting because of the complex shape of the sill complex, and because of the strong difference in density and acoustic velocity between sedimentary rocks and intrusives.<br>Dimensions:The model is 21 198 m long and 414 m high. The resolution of the model is 3 m/pixel laterally, and 0.5 m vertically. <br>Contents: <br>A1: Input model to seismic modelling, presented in paper as Figure 5D. Extrapolated architectural model of the sill-bearing parts of the Hurry Inlet section. Each pixel is 3 m in horizontal extent and 0.5 m in vertical extent. The gray values correspont to the following facies associations (FA in Table 1): FA1 (igneous intrusions, 97), FA2 (homogeneous sandstone. 159), FA3 (Sandstone, 124), FA4 (Poorly cemented sandstone, 55), FA5 (Heterolithic, 130), FA6 (mudstone, 111), and FA7 (Organic rich mudstone, 0). <br>A2: Very high-resolution versions of panels on left side of Fig. 11, showing comments and synthetic seismograms overlain the outcrop model. <br>A3: Very high-resolution version of panels on right side of Fig. 11, showing A) outcrop; B) reflectivity model; C) synthetic seismogram generated with seismogram using a 40 Hz wavelet and 80° max dip; D) Synthetic seismogram generated with seismogram using a 20 Hz wavelet and 50° max dip; E) Synthetic seismogram generated with seismogram using a 15Hz wavelet and 30° max dip. F) Synthetic seismogram generated with seismogram using a 10 Hz wavelet and 30° max dip. PSF: Point-spread function.<br>A4: Text version of A1.<br>A5: Spreadsheet showing input values and gray values used in modelling. <br>
DOI: 10.6084/m9.figshare.5607127
title: Geochemical and foraminiferal data. Influence of dominant wind patterns in a distal region of the NW Iberian Margin during the last glaciation

description: Geochemical and foraminiferal data.
DOI: 10.6084/m9.figshare.5607130
title: Pearson Correlations. Influence of dominant wind patterns in a distal region of the NW Iberian Margin during the last glaciation

description: Pearson Correlations between the analysed data.
DOI: 10.6084/m9.figshare.5607130.v1
title: Pearson Correlations. Influence of dominant wind patterns in a distal region of the NW Iberian Margin during the last glaciation

description: Pearson Correlations between the analysed data.
DOI: 10.6084/m9.figshare.5607160.v1
title: Seismic interpretation of sill complexes in sedimentary basins: implications for the sub-sill imaging problem

description: Supplementary files to the paper Seismic interpretation of sill complexes in sedimentary basins: implications for the sub-sill imaging problem by CH Eide et al<br>https://doi.org/10.1144/jgs2017-096<br>
DOI: 10.6084/m9.figshare.5607124

description: Observes convergence behaviour of different propagation algorithms. Generates Fig. 2 in the upcoming publication ''Finite difference methods for stationary and time-dependent x-ray propagation''.
DOI: 10.17045/sthlmuni.5607112
title: Species richness and composition differ in response to landscape and biogeography: data from Stockholm (outer) Archipelago (Baltic Sea), summer months 2009-2010.

description: Data for "Species richness and composition differ in response to landscape and biogeography" by Aggemyr, Auffret, Jädergård and Cousins.<br>The plant survey was conducted during the summers of 2009 and 2010 in the outher archipleago of Stockholm, Baltic Sea. A total of 112 islands are included in the data.<br><br>The data includes:"2009-2010Baltic_explanatoryVariables.csv" - explanatory variables from 112 islands: island area, height, group, distance to mainland, shannon diversity index for habitat heterogeneity, structural connectivity for buffer radii 100, 1000, and 4000 metres, and also geographical position in WGS84.<br>"2009-2010Baltic_speciesComposition.csv" - a matrix of species presence/absence on each island.<br>"2009-2010Baltic_speciesRichness.csv" - number of species on each island.<br>"2009-2010Baltic_lifeFormClassification.csv" - species classified into four different life forms.<br>"2009-2010Baltic_map.jpg" - a map illustrating Stockholm archipelago, Baltic Sea, and the surveyed islands.<br>"2009-2010Baltic_readMe.txt" - a more detailed file description.<br><br>Please feel free to get in touch!<br>