cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.7773827.v1
title: Magnetic resonance imaging of the breast: role in the evaluation of ductal carcinoma in situ

description: Abstract Ductal carcinoma in situ (DCIS) is a precursor mammary lesion whose malignant cells do not extend beyond the basement membrane and presents a risk of progression to malignant disease. Its early detection increased with screening mammography. The objective of this study was to review the literature on the main presentations of DCIS on magnetic resonance imaging (MRI), through searches of the Medline/PubMed, Latin-American and Caribbean Center on Health Sciences Information (Lilacs), and Scientific Electronic Library Online (SciELO) databases. DCIS can occur in its pure form or in conjunction with invasive disease, in the same lesion, in different foci, or in the contralateral breast. MRI has a high sensitivity for the detection of pure DCIS, being able to identify the non-calcified component, and its accuracy increases with the nuclear grade of the lesion. The most common pattern of presentation is non-nodular enhancement; heterogeneous internal structures; a kinetic curve showing washout or plateau enhancement; segmental distribution; and restricted diffusion. MRI plays an important role in the detection of DCIS, especially in the evaluation of its extent, contributing to more reliable surgical excision and reducing local recurrence.
DOI: 10.6084/m9.figshare.7773812
title: SYNTHESIS AND NUCLEAR MAGNETIC RELAXATION PROPERTIES OF COMPOSITE IRON OXIDE NANOPARTICLES

description: Superparamagnetic iron oxide nanoparticles are suitable contrast agents for magnetic resonance imaging due to their effect on proton relaxation times, and excellent biocompatibility and biodistribution in tissue. In the present study, a ferrofluid formed by dextran-coated iron oxide nanoparticles was prepared by the coprecipitation method and with subsequent steps of crosslinking and addition of functionalizations on the nanoparticle's surface (amino groups and a fluorophore). The effect of differences in the synthesis route (ratio of dextran to iron salts and temperature of the reaction) on the physico-chemical characteristics of the nanoparticles and their performance as contrast agents for magnetic resonance imaging was investigated. Overall, the nuclear magnetic relaxation times of water protons in aqueous suspensions of the nanoparticles did not show major differences among different batches, with no significant effect due to the addition of the fluorophore or changes in the dextran fraction of up to 50%. Larger reductions in the ratio of dextran to iron salts resulted in particles with slightly larger sizes, higher saturation magnetization and distinct nuclear magnetic relaxation times.
DOI: 10.6084/m9.figshare.7773815.v1
title: BETWEEN TYPES AND RADICALS: THE CONSTRUCTION OF THE CONCEPT OF VALENCE

description: This paper presents a historical case study regarding the development of the concept of valence in late nineteenth and early twentieth centuries. The case study focuses on Edward Frankland’s contribution to the process which lead to the convergence of two theories about the combination of the elements: the theory of types and the theory of radicals. Results show how such process involved many other scientists from various countries and how the concept of valence related to studies on bonding, periodicity and chemical structure. Changes in the nomenclature and notation were also observed. In the beginning of the twentieth century, the empirical concept of valence received theoretical explanations under the light of the then new theories on electronic structure of atoms. Thus, this case study exemplifies the complexity of the process of development of a scientific concept and, in particular, shows the multiplicity of connections of the concept of valence in the body of chemical knowledge.
DOI: 10.6084/m9.figshare.7773818
title: Predictors of Normalization of Circulating Interleukin-6 after Cardiac Myxoma Resection

description: Abstract Objective: To disclose the relationships between the anatomic features of cardiac myxomas and plasma interleukin (IL)-6 levels. Methods: Twelve patients undergoing cardiac myxoma resection at The First Hospital of Putian, Teaching Hospital, Fujian Medical University were enrolled into this study. Pre- and postoperative IL-6 levels were determined by an enzyme-linked immunosorbent assay method, and correlations between cardiac myxoma dimension or volume and plasma IL-6 levels were analyzed. C-reactive protein (CRP) levels were also evaluated. Results: IL-6 and CRP levels were significantly decreased one month after cardiac myxoma resection in comparison to preoperative values. IL-6 and CRP levels did not differ between patients with a cardiac myxoma of irregular appearance and those with a myxoma of regular gross appearance, or between patients with a pedicled or a sessile myxoma. Decrement of IL-6 of patients with irregular cardiac myxomas was much higher than that of patients with regular ones, while no intergroup difference was noted in decrement of CRP. A close direct correlation was noted between IL-6 levels and maximal dimension (length) or volume of cardiac myxomas, whereas CRP levels only correlated with maximal dimension of cardiac myxomas. Conclusion: Anatomic features of cardiac myxomas (sessile, irregular appearance, maximal dimension, and volume) could be determinants of the patients' circulating IL-6 levels. IL-6 was likely to be a more sensitive biomarker than CRP in predicting the inflammatory status of patients with cardiac myxoma. Sessile and irregular cardiac myxomas might predict more severe inflammatory conditions for their more abundant endothelial cells and IL-6 overproduction.
DOI: 10.6084/m9.figshare.7773806
title: Treadmill training and kinesiotherapy versus conventional physiotherapy in Parkinson’s disease: a pragmatic study

description: Abstract Introduction: Physiotherapy has been identified in the literature as an important treatment for individuals with Parkinson’s disease (PD) to improve functional capacity. Little is discussed about the physiotherapy practice environment for this population. Objective: To assess pragmatically the effects of two physiotherapy protocols: Conventional Physiotherapy (CP) and Treadmill Training and Kinesiotherapy (TTK) in PD patients. Method: Twenty-four PD patients classified from 1 to 3 on the Hoehn and Yahr scale were randomly distributed into two groups. In CP group (12 patients), exercises aimed to improve range of motion, bradykinesia, postural adjustments and gait. In TTK group (12 patients), exercises aimed to improve physical fitness, mobility and functional independence. The treatments were performed for 50 minutes, twice a week for 14 weeks. The following evaluations were performed before and after the interventions: Unified Parkinson’s Disease Rating Scale (UPDRS); gait speed (GS); up stairs (US) and down stairs (DS) tests; timed get-up-and-go test (TUG) and 6-Minute Walk Distance Test (6-MWDT). Sociodemographic and clinical data were presented as descriptive analysis. Variables with normal and non-normal distributions were analyzed by specific statistical tests. Results: Intragroup analysis showed significant results for the TTK group (TUG, US, DS, GS, UPDRS total and UPDRS II) and for the CP group only UPDRS total. Intergroup analysis was favorable for the TTK group (TUG, US, DS, 6-MWDT). Conclusion: CP group improved the patients’ general clinical status, while treadmill and kinesiotherapy improved the physical-functional and clinical aspects.
DOI: 10.6084/m9.figshare.7773812.v1
title: SYNTHESIS AND NUCLEAR MAGNETIC RELAXATION PROPERTIES OF COMPOSITE IRON OXIDE NANOPARTICLES

description: Superparamagnetic iron oxide nanoparticles are suitable contrast agents for magnetic resonance imaging due to their effect on proton relaxation times, and excellent biocompatibility and biodistribution in tissue. In the present study, a ferrofluid formed by dextran-coated iron oxide nanoparticles was prepared by the coprecipitation method and with subsequent steps of crosslinking and addition of functionalizations on the nanoparticle's surface (amino groups and a fluorophore). The effect of differences in the synthesis route (ratio of dextran to iron salts and temperature of the reaction) on the physico-chemical characteristics of the nanoparticles and their performance as contrast agents for magnetic resonance imaging was investigated. Overall, the nuclear magnetic relaxation times of water protons in aqueous suspensions of the nanoparticles did not show major differences among different batches, with no significant effect due to the addition of the fluorophore or changes in the dextran fraction of up to 50%. Larger reductions in the ratio of dextran to iron salts resulted in particles with slightly larger sizes, higher saturation magnetization and distinct nuclear magnetic relaxation times.
DOI: 10.6084/m9.figshare.7773818.v1
title: Predictors of Normalization of Circulating Interleukin-6 after Cardiac Myxoma Resection

description: Abstract Objective: To disclose the relationships between the anatomic features of cardiac myxomas and plasma interleukin (IL)-6 levels. Methods: Twelve patients undergoing cardiac myxoma resection at The First Hospital of Putian, Teaching Hospital, Fujian Medical University were enrolled into this study. Pre- and postoperative IL-6 levels were determined by an enzyme-linked immunosorbent assay method, and correlations between cardiac myxoma dimension or volume and plasma IL-6 levels were analyzed. C-reactive protein (CRP) levels were also evaluated. Results: IL-6 and CRP levels were significantly decreased one month after cardiac myxoma resection in comparison to preoperative values. IL-6 and CRP levels did not differ between patients with a cardiac myxoma of irregular appearance and those with a myxoma of regular gross appearance, or between patients with a pedicled or a sessile myxoma. Decrement of IL-6 of patients with irregular cardiac myxomas was much higher than that of patients with regular ones, while no intergroup difference was noted in decrement of CRP. A close direct correlation was noted between IL-6 levels and maximal dimension (length) or volume of cardiac myxomas, whereas CRP levels only correlated with maximal dimension of cardiac myxomas. Conclusion: Anatomic features of cardiac myxomas (sessile, irregular appearance, maximal dimension, and volume) could be determinants of the patients' circulating IL-6 levels. IL-6 was likely to be a more sensitive biomarker than CRP in predicting the inflammatory status of patients with cardiac myxoma. Sessile and irregular cardiac myxomas might predict more severe inflammatory conditions for their more abundant endothelial cells and IL-6 overproduction.
DOI: 10.6084/m9.figshare.7773797
title: Plantar pressure distribution evaluation in children with down syndrome from 2 to 5 years old

description: Abstract Introduction: Some peculiar features of Down Syndrome (DS), such as ligament laxity, hypotonia, delay in gait acquisition, among others, may generate alterations in the distribution of plantar pressures, modifying the plantar support. Objective: To verify whether there are differences in the evaluation of plantar pressure distributions in standing posture between the measurement instruments (Baropodometer, SAPO, and Radiography). Method: This was a cross-sectional study, evaluating ten children with SD and ten children with normal development (ND), aged from two to five years old. Bio-photogrammetry, baropodometry, and foot radiography were used to assess the plantar pressure distribution. Kappa analysis was used to evaluate the agreement index between the different instruments. Results: Children with DS and ND had a higher prevalence of pronated feet in all three instruments, with poor to substantial agreement among the instruments. Conclusion: According to this study instruments, there was a greater prevalence of pronated feet in the two groups . Differences in the evaluation of the distribution of plantar pressures in the standing posture between the Baropodometer, SAPO, and radiography were observed. These instruments should be used in a complementary manner, as they propose to evaluate different aspects of the feet alignment.
DOI: 10.6084/m9.figshare.7773800
title: Accuracy of clinical-functional tools to identify risk of falls among community-dwelling older adults

description: Abstract Introduction: The identification of older adults who present greater chances of falling is the first step in the prevention of falls. Clinical instruments have been shown to be able to differentiate fallers from non-fallers, but their predictive validity remains controversial. Objective: To investigate the accuracy of the Short Physical Performance Battery (SPPB) and Quick Screen Clinical Fall Risk Assessment (QuickScreen) instruments to identify risk of falls in community-dwelling older adults. Method: This is a prospective methodological study with 81 older adults (≥ 60 years), assessed at baseline by SPPB and QuickScreen and monitored after one year to identify the occurrence of falls. Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and area under the ROC curve (AUC) were calculated. Results: 28.4% of the sample reported falls. QuickScreen presented 52.2% sensitivity, 74.1% specificity, 44.4% PPV, 79.6% NPV and 0.656 AUC. The AUC for SPPB was not significant (p = 0.087). Conclusion: QuickScreen presented poor accuracy when predicting falls and SPPB was unable to identify community-dwelling older adults at risk of falls. The QuickScreen instrument stood out for its high potential to identify true negatives.
DOI: 10.6084/m9.figshare.7773803
title: The chronic effects of muscle-resistance training in arterial pressure of hypertensive older adults: a meta-analysis

description: Abstract Introduction: Little research has been done on the effects of muscle-resistance training (RT) in hypertensive older adults. Objective: The aim of this meta-analysis was to verify the efficacy of RT, on a chronic basis, on the systolic (SBP) and diastolic blood pressure (DBP) of hypertensive older adults. Method: Several literature databases were explored to find studies on controlled and randomized trials that evaluated the effects of RT in hypertensive older adults for more than 10 weeks. Profile of the participants, sample size, intervention protocol, and results of SBP and DBP were analyzed. The PEDro scale and the Cochrane tool were used to analyze the methodological quality of the studies and the risk of bias, respectively. The RevMan5.3 program was used to analyze the results on the SBP and DBP after the RT intervention and in the control groups. Results: The meta-analysis of five studies considering 96 hypertensive individuals who underwent RT and 104 hypertensive control subjects showed that the regular practice of RT from 12 to 16 weeks, three times a week, with three sets from 8 to 12 repetitions at an intensity of 60% to 80% of one-repetition maximum (1-RM), significantly reduced SBP by 7.26 mmHg (95%CI = -9.16 - 5.37) and DBP by 4.84 mmHg (95%CI = -5.89 - 3.79). Conclusion: The muscle-resistance training was effective in reducing, chronically, the blood pressure of hypertensive older adults. It can also decrease the need for medication inherent to hypertension.
DOI: 10.6084/m9.figshare.7773797.v1
title: Plantar pressure distribution evaluation in children with down syndrome from 2 to 5 years old

description: Abstract Introduction: Some peculiar features of Down Syndrome (DS), such as ligament laxity, hypotonia, delay in gait acquisition, among others, may generate alterations in the distribution of plantar pressures, modifying the plantar support. Objective: To verify whether there are differences in the evaluation of plantar pressure distributions in standing posture between the measurement instruments (Baropodometer, SAPO, and Radiography). Method: This was a cross-sectional study, evaluating ten children with SD and ten children with normal development (ND), aged from two to five years old. Bio-photogrammetry, baropodometry, and foot radiography were used to assess the plantar pressure distribution. Kappa analysis was used to evaluate the agreement index between the different instruments. Results: Children with DS and ND had a higher prevalence of pronated feet in all three instruments, with poor to substantial agreement among the instruments. Conclusion: According to this study instruments, there was a greater prevalence of pronated feet in the two groups . Differences in the evaluation of the distribution of plantar pressures in the standing posture between the Baropodometer, SAPO, and radiography were observed. These instruments should be used in a complementary manner, as they propose to evaluate different aspects of the feet alignment.
DOI: 10.6084/m9.figshare.7773800.v1
title: Accuracy of clinical-functional tools to identify risk of falls among community-dwelling older adults

description: Abstract Introduction: The identification of older adults who present greater chances of falling is the first step in the prevention of falls. Clinical instruments have been shown to be able to differentiate fallers from non-fallers, but their predictive validity remains controversial. Objective: To investigate the accuracy of the Short Physical Performance Battery (SPPB) and Quick Screen Clinical Fall Risk Assessment (QuickScreen) instruments to identify risk of falls in community-dwelling older adults. Method: This is a prospective methodological study with 81 older adults (≥ 60 years), assessed at baseline by SPPB and QuickScreen and monitored after one year to identify the occurrence of falls. Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and area under the ROC curve (AUC) were calculated. Results: 28.4% of the sample reported falls. QuickScreen presented 52.2% sensitivity, 74.1% specificity, 44.4% PPV, 79.6% NPV and 0.656 AUC. The AUC for SPPB was not significant (p = 0.087). Conclusion: QuickScreen presented poor accuracy when predicting falls and SPPB was unable to identify community-dwelling older adults at risk of falls. The QuickScreen instrument stood out for its high potential to identify true negatives.
DOI: 10.6084/m9.figshare.7773803.v1
title: The chronic effects of muscle-resistance training in arterial pressure of hypertensive older adults: a meta-analysis

description: Abstract Introduction: Little research has been done on the effects of muscle-resistance training (RT) in hypertensive older adults. Objective: The aim of this meta-analysis was to verify the efficacy of RT, on a chronic basis, on the systolic (SBP) and diastolic blood pressure (DBP) of hypertensive older adults. Method: Several literature databases were explored to find studies on controlled and randomized trials that evaluated the effects of RT in hypertensive older adults for more than 10 weeks. Profile of the participants, sample size, intervention protocol, and results of SBP and DBP were analyzed. The PEDro scale and the Cochrane tool were used to analyze the methodological quality of the studies and the risk of bias, respectively. The RevMan5.3 program was used to analyze the results on the SBP and DBP after the RT intervention and in the control groups. Results: The meta-analysis of five studies considering 96 hypertensive individuals who underwent RT and 104 hypertensive control subjects showed that the regular practice of RT from 12 to 16 weeks, three times a week, with three sets from 8 to 12 repetitions at an intensity of 60% to 80% of one-repetition maximum (1-RM), significantly reduced SBP by 7.26 mmHg (95%CI = -9.16 - 5.37) and DBP by 4.84 mmHg (95%CI = -5.89 - 3.79). Conclusion: The muscle-resistance training was effective in reducing, chronically, the blood pressure of hypertensive older adults. It can also decrease the need for medication inherent to hypertension.
DOI: 10.6084/m9.figshare.7773806.v1
title: Treadmill training and kinesiotherapy versus conventional physiotherapy in Parkinson’s disease: a pragmatic study

description: Abstract Introduction: Physiotherapy has been identified in the literature as an important treatment for individuals with Parkinson’s disease (PD) to improve functional capacity. Little is discussed about the physiotherapy practice environment for this population. Objective: To assess pragmatically the effects of two physiotherapy protocols: Conventional Physiotherapy (CP) and Treadmill Training and Kinesiotherapy (TTK) in PD patients. Method: Twenty-four PD patients classified from 1 to 3 on the Hoehn and Yahr scale were randomly distributed into two groups. In CP group (12 patients), exercises aimed to improve range of motion, bradykinesia, postural adjustments and gait. In TTK group (12 patients), exercises aimed to improve physical fitness, mobility and functional independence. The treatments were performed for 50 minutes, twice a week for 14 weeks. The following evaluations were performed before and after the interventions: Unified Parkinson’s Disease Rating Scale (UPDRS); gait speed (GS); up stairs (US) and down stairs (DS) tests; timed get-up-and-go test (TUG) and 6-Minute Walk Distance Test (6-MWDT). Sociodemographic and clinical data were presented as descriptive analysis. Variables with normal and non-normal distributions were analyzed by specific statistical tests. Results: Intragroup analysis showed significant results for the TTK group (TUG, US, DS, GS, UPDRS total and UPDRS II) and for the CP group only UPDRS total. Intergroup analysis was favorable for the TTK group (TUG, US, DS, 6-MWDT). Conclusion: CP group improved the patients’ general clinical status, while treadmill and kinesiotherapy improved the physical-functional and clinical aspects.
DOI: 10.6084/m9.figshare.7773791
title: Increased urinary losses in piglets fed diets containing high levels of glycerin

description: ABSTRACT This study evaluated the nutritional value of glycerin added to diets of weaned piglets and its effects on animal performance and urinary losses. Weaned piglets were individually housed in metabolic cages and fed diets in which a basal diet containing lactose (Gly0) was replaced by 50 (Gly50), 100 (Gly100), or 150 g kg−1 (Gly150) of glycerin; or a diet in which 100 g kg−1 of the lactose in the basal diet was replaced by glycerin (Gly100Lac0). Diets were offered for two periods of 12 days (phase I and phase II). Performance, nutrient digestibility, nitrogen retention (NR), and urinary production were measured. Digestible (DE) and metabolizable energy (ME) of glycerin were calculated using substitution method and compared to iso-nutritional diets formulated with or without glycerin. No significant differences on average daily gain, average daily feed intake, and feed conversion ratio were found. Glycerin inclusion caused a linear increase in urinary production. Piglets fed Gly100Lac0 diet had higher urinary production, compared with piglets fed Gly0. Glycerin had no significant effects on total tract apparent digestibility (TTAD) coefficients of dry matter (DM), crude protein, and gross energy (GE). Also, no significant effects were found in total tract apparent metabolizability (TTAM) coefficient of GE, NR coefficient, DE, ME, and fecal GE losses. Urinary production and GE in urine increased linearly and quadratically, respectively, with increased levels of glycerin in diets. The Gly100Lac0 diet resulted in lower DM TTAD and GE TTAM and higher GE losses in urine and feces compared with Gly0. The nutritional value of glycerin allows its inclusion at up to 100 g kg−1 in diets of weaned piglets without impairing animal performance and metabolism. Also, glycerin can replace 100 g kg−1 of lactose without impairing performance.