cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.29150022
title: Improved antidiabetic potential of quercetin-loaded chitosan–lecithin nanoparticles for effective glycaemic control

description: Diabetes mellitus is a major global health challenge, causing significant morbidity and mortality. Quercetin (QTN), a natural flavonoid, has potential antidiabetic and insulin-sensitising effects. However, its clinical use is limited by poor solubility and bioavailability. We developed the QTN loaded chitosan–lecithin nanoparticles (QTN/LCHS-NPs) to enhance its therapeutic profile. QTN/LCHS-NPs were synthesised using a 20:1 lecithin:chitosan ratio. Characterisation included encapsulation efficiency (�), particle size and zeta potential (ZP). <i>In vitro</i>, drug release studies were conducted to evaluate release kinetics. <i>In vivo,</i> pharmacokinetic and pharmacodynamic studies were performed in male Wistar rats to assess bioavailability, antidiabetic activity and lipid-modulating effects. The optimised QTN/LCHS-NP formulation exhibited 79.72% �, diameter of 130.1 nm, and a ZP of 23.46 mV. <i>In vitro</i> release studies showed a biphasic pattern, with an initial burst release followed by a sustained release of 86.10% over 24 h. Bioavailability (area under the curve, AUC: 167.22 h⋅µg/mL) exceeded free QTN (AUC: 26.2 h⋅µg/mL). Fasting blood glucose decreased from 292.9 to 107.7 mg/dL, along with improved lipid profiles. QTN/LCHS-NPs significantly enhanced the oral bioavailability of QTN and improved its antidiabetic and antihyperlipidaemic effects, demonstrating their potential as an effective delivery system for addressing metabolic disorders.
DOI: 10.6084/m9.figshare.29150022.v2
title: Improved antidiabetic potential of quercetin-loaded chitosan–lecithin nanoparticles for effective glycaemic control

description: Diabetes mellitus is a major global health challenge, causing significant morbidity and mortality. Quercetin (QTN), a natural flavonoid, has potential antidiabetic and insulin-sensitising effects. However, its clinical use is limited by poor solubility and bioavailability. We developed the QTN loaded chitosan–lecithin nanoparticles (QTN/LCHS-NPs) to enhance its therapeutic profile. QTN/LCHS-NPs were synthesised using a 20:1 lecithin:chitosan ratio. Characterisation included encapsulation efficiency (�), particle size and zeta potential (ZP). <i>In vitro</i>, drug release studies were conducted to evaluate release kinetics. <i>In vivo,</i> pharmacokinetic and pharmacodynamic studies were performed in male Wistar rats to assess bioavailability, antidiabetic activity and lipid-modulating effects. The optimised QTN/LCHS-NP formulation exhibited 79.72% �, diameter of 130.1 nm, and a ZP of 23.46 mV. <i>In vitro</i> release studies showed a biphasic pattern, with an initial burst release followed by a sustained release of 86.10% over 24 h. Bioavailability (area under the curve, AUC: 167.22 h⋅µg/mL) exceeded free QTN (AUC: 26.2 h⋅µg/mL). Fasting blood glucose decreased from 292.9 to 107.7 mg/dL, along with improved lipid profiles. QTN/LCHS-NPs significantly enhanced the oral bioavailability of QTN and improved its antidiabetic and antihyperlipidaemic effects, demonstrating their potential as an effective delivery system for addressing metabolic disorders.
DOI: 10.5517/ccdc.csd.cc10q0pf
title: CCDC 944684: Experimental Crystal Structure Determination

description: Related Article: Christopher M. Kane, Arash Banisafar, Timothy P. Dougherty, Leonard J. Barbour, and K. Travis Holman|2016|J.Am.Chem.Soc.|138|4377|doi:10.1021/jacs.5b11395
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.6084/m9.figshare.29150022.v1
title: Improved Antidiabetic Potential of Quercetin-Loaded Chitosan-Lecithin Nanoparticles for Effective Glycemic Control

description: Introduction Diabetes mellitus is a major global health challenge, causing significant morbidity and mortality. Quercetin, a natural flavonoid, has potential antidiabetic and insulin-sensitizing effects. However, its clinical use is limited by poor solubility and bioavailability. We developed the quercetin (QTN) loaded chitosan-lecithin nanoparticles (QTN/LCHS-NPs) to enhance its therapeutic profile. Materials and Methods QTN/LCHS-NPs were synthesized using a 20:1 lecthin:chitosan ratio. Characterization included encapsulation efficiency, particle size, and zeta potential. <i>In vitro</i>, drug release studies were conducted to evaluate release kinetics. <i>In vivo,</i> pharmacokinetic and pharmacodynamic studies were performed in male Wistar rats to assess bioavailability, antidiabetic activity, and lipid-modulating effects. Results The optimized QTN/LCHS-NP formulation exhibited 79.72% encapsulation efficiency, diameter of 130.1 nm, and a zeta potential of 23.46 mV. <i>In vitro</i> release studies showed a biphasic pattern, with an initial burst release followed by a sustained release of 86.10% over 24 h. Bioavailability (AUC: 167.22 h⋅µg/mL) exceeded free QTN (AUC: 26.2 h⋅µg/mL). Fasting blood glucose decreased from 292.9 to 107.7 mg/dL, along with improved lipid profiles. Conclusion QTN/LCHS-NPs significantly enhanced the oral bioavailability of quercetin and improved its antidiabetic and antihyperlipidemic effects, demonstrating their potential as an effective delivery system for addressing metabolic disorders.
DOI: 10.5517/ccdc.csd.cc111p0s
title: CCDC 954924: Experimental Crystal Structure Determination

description: Related Article: Christopher M. Kane, Arash Banisafar, Timothy P. Dougherty, Leonard J. Barbour, and K. Travis Holman|2016|J.Am.Chem.Soc.|138|4377|doi:10.1021/jacs.5b11395
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.ccz1kzj
title: CCDC 895248: Experimental Crystal Structure Determination

description: Related Article: Christopher M. Kane, Arash Banisafar, Timothy P. Dougherty, Leonard J. Barbour, and K. Travis Holman|2016|J.Am.Chem.Soc.|138|4377|doi:10.1021/jacs.5b11395
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/cc1jhlby
title: CCDC 1415160: Experimental Crystal Structure Determination

description: Related Article: Jiangjiao Shi, Chunhua Gong, Xianghua Zeng, Junyong Zhang, Chengfeng Zhu, Jingli Xie|2015|Polyhedron|102|562|doi:10.1016/j.poly.2015.10.002
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.ccz1lq9
title: CCDC 895271: Experimental Crystal Structure Determination

description: Related Article: Christopher M. Kane, Arash Banisafar, Timothy P. Dougherty, Leonard J. Barbour, and K. Travis Holman|2016|J.Am.Chem.Soc.|138|4377|doi:10.1021/jacs.5b11395
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.ccz1l5r
title: CCDC 895254: Experimental Crystal Structure Determination

description: Related Article: Christopher M. Kane, Arash Banisafar, Timothy P. Dougherty, Leonard J. Barbour, and K. Travis Holman|2016|J.Am.Chem.Soc.|138|4377|doi:10.1021/jacs.5b11395
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.ccz1stl
title: CCDC 895460: Experimental Crystal Structure Determination

description: Related Article: Christopher M. Kane, Arash Banisafar, Timothy P. Dougherty, Leonard J. Barbour, and K. Travis Holman|2016|J.Am.Chem.Soc.|138|4377|doi:10.1021/jacs.5b11395
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/cc1jhnth
title: CCDC 1415237: Experimental Crystal Structure Determination

description: Related Article: Manisha Devi, Abhimanew Dhir, Chullikkattil P. Pradeep|2016|New J.Chem.|40|1269|doi:10.1039/C5NJ02175H
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.ccz1lp8
title: CCDC 895270: Experimental Crystal Structure Determination

description: Related Article: Christopher M. Kane, Arash Banisafar, Timothy P. Dougherty, Leonard J. Barbour, and K. Travis Holman|2016|J.Am.Chem.Soc.|138|4377|doi:10.1021/jacs.5b11395
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc10p3xq
title: CCDC 943823: Experimental Crystal Structure Determination

description: Related Article: Christopher M. Kane, Arash Banisafar, Timothy P. Dougherty, Leonard J. Barbour, and K. Travis Holman|2016|J.Am.Chem.Soc.|138|4377|doi:10.1021/jacs.5b11395
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.ccz1ldz
title: CCDC 895261: Experimental Crystal Structure Determination

description: Related Article: Christopher M. Kane, Arash Banisafar, Timothy P. Dougherty, Leonard J. Barbour, and K. Travis Holman|2016|J.Am.Chem.Soc.|138|4377|doi:10.1021/jacs.5b11395
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.15468/dl.d6ux4f
title: Occurrence Download

description: A dataset containing 9 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Geometry POLYGON((8.30337 42.97977,8.45885 41.37674,9.83134 41.2856,9.55791 43.08699,8.30337 42.97977))",
 "TaxonKey is Cupido alcetas"
 ]
}

 The dataset includes 9 records from 6 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0052305-251009101135966/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.5517/cc1jhnvj
title: CCDC 1415238: Experimental Crystal Structure Determination

description: Related Article: R.R. Swamy, R. Gowda, K.V.A. Gowda, M. Basanagouda|2015|Acta Crystallogr.,Sect.E:Cryst.Commun.|71|o617|doi:10.1107/S2056989015014103
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.ccz1lh2
title: CCDC 895264: Experimental Crystal Structure Determination

description: Related Article: Christopher M. Kane, Arash Banisafar, Timothy P. Dougherty, Leonard J. Barbour, and K. Travis Holman|2016|J.Am.Chem.Soc.|138|4377|doi:10.1021/jacs.5b11395
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.ccz1lm6
title: CCDC 895268: Experimental Crystal Structure Determination

description: Related Article: Christopher M. Kane, Arash Banisafar, Timothy P. Dougherty, Leonard J. Barbour, and K. Travis Holman|2016|J.Am.Chem.Soc.|138|4377|doi:10.1021/jacs.5b11395
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.ccz1lj3
title: CCDC 895265: Experimental Crystal Structure Determination

description: Related Article: Christopher M. Kane, Arash Banisafar, Timothy P. Dougherty, Leonard J. Barbour, and K. Travis Holman|2016|J.Am.Chem.Soc.|138|4377|doi:10.1021/jacs.5b11395
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.ccz1ltd
title: CCDC 895274: Experimental Crystal Structure Determination

description: Related Article: Christopher M. Kane, Arash Banisafar, Timothy P. Dougherty, Leonard J. Barbour, and K. Travis Holman|2016|J.Am.Chem.Soc.|138|4377|doi:10.1021/jacs.5b11395
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/cc14gnv3
title: CCDC 1056785: Experimental Crystal Structure Determination

description: Related Article: Jiaming Tang, Bingqing Xu, Xi Mao, Hongyan Yang, Xiaoxia Wang, and Xin Lv|2015|J.Org.Chem.|80|11108|doi:10.1021/acs.joc.5b01745
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.15468/dl.jzbjyz
title: Occurrence Download

description: A dataset containing 35 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Cinnamodendron sampaioanum"
 ]
}

 The dataset includes 35 records from 16 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0052306-251009101135966/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.5517/cc149lxy
title: CCDC 1051920: Experimental Crystal Structure Determination

description: Related Article: Ming Luo, Congqing Zhu, Lina Chen, Hong Zhang, Haiping Xia|2016|Chemical Science|7|1815|doi:10.1039/C5SC03963K
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/cc1jhnxl
title: CCDC 1415240: Experimental Crystal Structure Determination

description: Related Article: Caroline Bosch, Béla Fiser, Enrique Gómez-Bengoa, Ben Bradshaw, and Josep Bonjoch|2015|Org.Lett.|17|5084|doi:10.1021/acs.orglett.5b02581
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/cc1jhs93
title: CCDC 1415345: Experimental Crystal Structure Determination

description: Related Article: Ming Luo, Congqing Zhu, Lina Chen, Hong Zhang, Haiping Xia|2016|Chemical Science|7|1815|doi:10.1039/C5SC03963K
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc1jhnzn
title: CCDC 1415242: Experimental Crystal Structure Determination

description: Related Article: Oksana Toma, Magali Allain, Franco Meinardi, Alessandra Forni, Chiara Botta, Nicolas Mercier|2016|Angew.Chem.,Int.Ed.|55|7998|doi:10.1002/anie.201602602
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc1jhp1r
title: CCDC 1415244: Experimental Crystal Structure Determination

description: Related Article: Oksana Toma, Magali Allain, Franco Meinardi, Alessandra Forni, Chiara Botta, Nicolas Mercier|2016|Angew.Chem.,Int.Ed.|55|7998|doi:10.1002/anie.201602602
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/cc1jhpg5
title: CCDC 1415257: Experimental Crystal Structure Determination

description: Related Article: M.B. Diop, L. Diop, T. Maris|2015|Acta Crystallogr.,Sect.E:Cryst.Commun.|71|1064|doi:10.1107/S2056989015014127
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/cc1jhph6
title: CCDC 1415258: Experimental Crystal Structure Determination

description: Related Article: Oksana Toma, Maxime Leroux, Nicolas Mercier, Magali Allain, Abdel Hadi Kassiba, Shashi Kumar Kumara Swamy, Jens Dittmer|2016|Eur.J.Org.Chem.|2016|1036|doi:10.1002/ejic.201501206
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/cc1jhpj7
title: CCDC 1415259: Experimental Crystal Structure Determination

description: Related Article: Oksana Toma, Maxime Leroux, Nicolas Mercier, Magali Allain, Abdel Hadi Kassiba, Shashi Kumar Kumara Swamy, Jens Dittmer|2016|Eur.J.Org.Chem.|2016|1036|doi:10.1002/ejic.201501206
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/cc1jhpk8
title: CCDC 1415260: Experimental Crystal Structure Determination

description: Related Article: Oksana Toma, Maxime Leroux, Nicolas Mercier, Magali Allain, Abdel Hadi Kassiba, Shashi Kumar Kumara Swamy, Jens Dittmer|2016|Eur.J.Org.Chem.|2016|1036|doi:10.1002/ejic.201501206
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/cc1jhpl9
title: CCDC 1415261: Experimental Crystal Structure Determination

description: Related Article: Jian Yang, Yang Gao, Xiaorong Tang|2015|CSD Communication|||
description: Related Article: J.Yang, Ya.Gao, H.Liu, X.Tang|2017|Khim.Prir.Soedin|53|1112|doi:10.1007/s10600-017-2212-z
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/cc1jhppd
title: CCDC 1415264: Experimental Crystal Structure Determination

description: Related Article: A.H. Haines, D.L. Hughes|2015|Acta Crystallogr.,Sect.E:Cryst.Commun.|71|993|doi:10.1107/S2056989015014139
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.