cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.5281/zenodo.10423286
title: Hardy Tree (Camden, UK) and gravestones

description: This is the Hardy Tree in [St Pancras Old Church](https://goo.gl/9AiihJ), Camden, London, UK ([OSM](https://goo.gl/ydVXeA)). The tree was reportedly planted by the author Thomas Hardy and the roots are embedded in pile of gravestones. 

![hardy_tree](http://www.estatevaults.com/lm/-Hardy_tree_St_Pancras_London.jpg)

The point cloud is a combination of a RIEGL VZ-400 scan and a ZEB-REVO (to get detail around the gravestones). Scanning done by University College London ([@kungphil](https://twitter.com/kungphil), [@mathiasdisney](https://twitter.com/mathiasdisney), [@UCLgeography](https://twitter.com/UCLgeography)).

This work was funded by the NERC National Centre for Earth Observation (NCEO).

Source: Objaverse 1.0 / Sketchfab
DOI: 10.5281/zenodo.10423287
title: Hardy Tree (Camden, UK) and gravestones

description: This is the Hardy Tree in [St Pancras Old Church](https://goo.gl/9AiihJ), Camden, London, UK ([OSM](https://goo.gl/ydVXeA)). The tree was reportedly planted by the author Thomas Hardy and the roots are embedded in pile of gravestones. 

![hardy_tree](http://www.estatevaults.com/lm/-Hardy_tree_St_Pancras_London.jpg)

The point cloud is a combination of a RIEGL VZ-400 scan and a ZEB-REVO (to get detail around the gravestones). Scanning done by University College London ([@kungphil](https://twitter.com/kungphil), [@mathiasdisney](https://twitter.com/mathiasdisney), [@UCLgeography](https://twitter.com/UCLgeography)).

This work was funded by the NERC National Centre for Earth Observation (NCEO).

Source: Objaverse 1.0 / Sketchfab
DOI: 10.5281/zenodo.10423288
title: PNRP F.1.28.125.1.K View 2

description: This L clavicle fragment was excavated from a 2nd century B.C. - 1st century A.D. tomb (F.1) from the North Ridge cemetery area in Petra, Jordan. 3D modeling and photography of this element was conducted under the permanent loan agreement No. 12/5/2288 between the Department of Antiquities of Jordan and East Carolina University.

Source: Objaverse 1.0 / Sketchfab
DOI: 10.5281/zenodo.10423289
title: PNRP F.1.28.125.1.K View 2

description: This L clavicle fragment was excavated from a 2nd century B.C. - 1st century A.D. tomb (F.1) from the North Ridge cemetery area in Petra, Jordan. 3D modeling and photography of this element was conducted under the permanent loan agreement No. 12/5/2288 between the Department of Antiquities of Jordan and East Carolina University.

Source: Objaverse 1.0 / Sketchfab
DOI: 10.5281/zenodo.10423291
title: Coyolxauhqui Stone at Templo Mayor

description: In Aztec mythology, Coyolxauhqui was a daughter of Coatlicue and Mixcoatl and is the leader of the Centzon Huitznahuas, the southern star gods. Coyolxauhqui ruled over her brothers, the Four Hundred Southerners, she led them in attack against their mother, Coatlicue, when they learned she was pregnant, convinced she dishonored them all.

The disk depicting a dismembered Coyolxauhqui was found during construction in 1978 in Mexico City. Its discovery led to the excavation of the Templo Mayor.

Source: https://en.wikipedia.org/wiki/Coyolxauhqui

Source: Objaverse 1.0 / Sketchfab
DOI: 10.5281/zenodo.10423290
title: Coyolxauhqui Stone at Templo Mayor

description: In Aztec mythology, Coyolxauhqui was a daughter of Coatlicue and Mixcoatl and is the leader of the Centzon Huitznahuas, the southern star gods. Coyolxauhqui ruled over her brothers, the Four Hundred Southerners, she led them in attack against their mother, Coatlicue, when they learned she was pregnant, convinced she dishonored them all.

The disk depicting a dismembered Coyolxauhqui was found during construction in 1978 in Mexico City. Its discovery led to the excavation of the Templo Mayor.

Source: https://en.wikipedia.org/wiki/Coyolxauhqui

Source: Objaverse 1.0 / Sketchfab
DOI: 10.5281/zenodo.10423292
title: FMP WIP Sword-1

description: Work in Progress Sword I am using as part of my Final Major Project for College. Any tips are greatly recomended in the comments.

Source: Objaverse 1.0 / Sketchfab
DOI: 10.5281/zenodo.10423293
title: FMP WIP Sword-1

description: Work in Progress Sword I am using as part of my Final Major Project for College. Any tips are greatly recomended in the comments.

Source: Objaverse 1.0 / Sketchfab
DOI: 10.5281/zenodo.10423294
title: Calcite Vase No. 20, Mleiha, Sharjah, UAE.

description: Calcite Vase No. 20 of 47, from cache, Mleiha, Sharjah, UAE. The find was made by the Sharjah Archaeology Authority. 2nd-3rd Century CE. 225 photos. Completely processed (aligned, scaled, modeled, cleaned, simplified, unwrapped, textured, meshed) in Reality Capture.

J. Mª Córdoba 2016. La era de Mleiha: navegantes y caravanas antes del Islam. Pp 83-130 (Figure p. 92). In EN LOS CONFINES DE ORIENTE PRÓXIMO: El hallazgo moderno del país de Magán. Museo Arqueológico Nacional Catálogo de la Exposición Temporal Celebrada entre el 18 de abril y el 29 de mayo de 2016. Comisario: J. Mª Córdoba Zoilo. Comisarias adjuntas: C. del Cerro Linares, Mª C. Pérez Díe, E. Pons Mellado.

Source: Objaverse 1.0 / Sketchfab
DOI: 10.5281/zenodo.10423295
title: Calcite Vase No. 20, Mleiha, Sharjah, UAE.

description: Calcite Vase No. 20 of 47, from cache, Mleiha, Sharjah, UAE. The find was made by the Sharjah Archaeology Authority. 2nd-3rd Century CE. 225 photos. Completely processed (aligned, scaled, modeled, cleaned, simplified, unwrapped, textured, meshed) in Reality Capture.

J. Mª Córdoba 2016. La era de Mleiha: navegantes y caravanas antes del Islam. Pp 83-130 (Figure p. 92). In EN LOS CONFINES DE ORIENTE PRÓXIMO: El hallazgo moderno del país de Magán. Museo Arqueológico Nacional Catálogo de la Exposición Temporal Celebrada entre el 18 de abril y el 29 de mayo de 2016. Comisario: J. Mª Córdoba Zoilo. Comisarias adjuntas: C. del Cerro Linares, Mª C. Pérez Díe, E. Pons Mellado.

Source: Objaverse 1.0 / Sketchfab
DOI: 10.5281/zenodo.10423297
title: Drinking Fountain Barnsbury London

description: In small park on corner of Thornhill Road and Lofting Road in Barnsbury.

Photographed November 2018 using Sony a6000. Processed in Agisoft Photoscan.

http://www.mdfcta.co.uk/details-f/f239.html

88 photos taken in November 2018 with a Sony a6000 and processed in Agisoft Metashape.

Source: Objaverse 1.0 / Sketchfab
DOI: 10.5281/zenodo.10423296
title: Drinking Fountain Barnsbury London

description: In small park on corner of Thornhill Road and Lofting Road in Barnsbury.

Photographed November 2018 using Sony a6000. Processed in Agisoft Photoscan.

http://www.mdfcta.co.uk/details-f/f239.html

88 photos taken in November 2018 with a Sony a6000 and processed in Agisoft Metashape.

Source: Objaverse 1.0 / Sketchfab
DOI: 10.5281/zenodo.10423298
title: PERCUTOR EMPLEADO EN EL PROCESO METALÚRGICO

description: Source: Objaverse 1.0 / Sketchfab
DOI: 10.5281/zenodo.10423299
title: PERCUTOR EMPLEADO EN EL PROCESO METALÚRGICO

description: Source: Objaverse 1.0 / Sketchfab
DOI: 10.5281/zenodo.10423300
title: Door leaf from the house of Szymon Kluger

description: Full name: **Door leaf from the house of Szymon Kluger in Oświęcim, Poland**

Door leaf from the over century-old Kluger Family House in Oświęcim, preserved before the 2013-14 renovation of the building. In all probability the door led from the kitchen to the corridor. At present, it is part of the interior design of Café Bergson, run by the Auschwitz Jewish Center (AJC). 

**For more images and further information, visit:** https://muzea.malopolska.pl/pl/lista-obiektow/3014

Inventory number: MZ-414-O

Localisation of the physical object: [Auschwitz Jewish Center](https://ajcf.pl/en/), Oświęcim, Poland 

**Digitalisation: Regional Digitalisation Lab, Małopolska Institute of Culture in Kraków, Poland; "Virtual Museums of Małopolska" project**

Source: Objaverse 1.0 / Sketchfab
DOI: 10.5281/zenodo.10423301
title: Door leaf from the house of Szymon Kluger

description: Full name: **Door leaf from the house of Szymon Kluger in Oświęcim, Poland**

Door leaf from the over century-old Kluger Family House in Oświęcim, preserved before the 2013-14 renovation of the building. In all probability the door led from the kitchen to the corridor. At present, it is part of the interior design of Café Bergson, run by the Auschwitz Jewish Center (AJC). 

**For more images and further information, visit:** https://muzea.malopolska.pl/pl/lista-obiektow/3014

Inventory number: MZ-414-O

Localisation of the physical object: [Auschwitz Jewish Center](https://ajcf.pl/en/), Oświęcim, Poland 

**Digitalisation: Regional Digitalisation Lab, Małopolska Institute of Culture in Kraków, Poland; "Virtual Museums of Małopolska" project**

Source: Objaverse 1.0 / Sketchfab
DOI: 10.5281/zenodo.10423302
title: GEK-6986

description: Source: Objaverse 1.0 / Sketchfab
DOI: 10.5281/zenodo.10423303
title: GEK-6986

description: Source: Objaverse 1.0 / Sketchfab
DOI: 10.7910/dvn/5itqa9
title: Dataset for the paper: Institutional Gap and Enterprise Behavior: Evidence from China

description: Enterprise data
DOI: 10.6084/m9.figshare.24222730
title: Data and Do File

description: In this file are the data and the Do File used for the econometric logit model.
DOI: 10.6084/m9.figshare.24222730.v1
title: Data and Do File

description: In this file are the data and the Do File used for the econometric logit model.
DOI: 10.34740/kaggle/dsv/7300181
title: Glaucoma Dataset: EyePACS-AIROGS-light-V2
DOI: 10.34740/kaggle/dsv/7300206
title: Glaucoma Dataset: EyePACS-AIROGS-light-V2
DOI: 10.6084/m9.figshare.22362002
title: Identifying novel therapeutic inhibitors to target FMS-like tyrosine kinase-3 (FLT3) against acute myeloid leukemia: a molecular docking, molecular dynamics, and DFT study

description: Around 30% of acute myeloid leukemia (AML) patients have triggering mutations in Feline McDonough Sarcoma (FMS)-like tyrosine kinase 3 (FLT3), which has been suggested as a possible therapeutic candidate for AML therapy. Many tyrosine kinase inhibitors are available and have a wide variety of applications in the treatment of cancer by inhibiting subsequent steps of cell proliferation. Therefore, our study aims to identify effective antileukemic agents against FLT3 gene. Initially, well-known antileukemic drug candidates have been chosen to generate a structure-based pharmacophore model to assist the virtual screening of 217,77,093 compounds from the Zinc database. The final hits compounds were retrieved and evaluated by docking against the target protein, where the top four compounds have been selected for the analysis of ADMET. Based on the density functional theory (DFT), the geometry optimization, frontier molecular orbital (FMO), HOMO-LUMO, and global reactivity descriptor values have been evaluated that confirming a satisfactory profile and reactivity order for the selected candidates. In comparison to control compounds, the docking results revealed that the four compounds had substantial binding energies (-11.1 to −11.5 kcal/mol) with FLT3. The physicochemical and ADMET (adsorption, distribution, metabolism, excretion, toxicity) prediction results corresponded to the bioactive and safe candidates. Molecular dynamics (MD) confirmed the better binding affinity and stability compared to gilteritinib as a potential FLT3 inhibitor. In this study, a computational approach has been performed that found a better docking and dynamics score against target proteins, indicating potent and safe antileukemic agents, furthermore <i>in-vivo</i> and <i>in-vitro</i> investigations are recommended. Communicated by Ramaswamy H. Sarma
DOI: 10.6084/m9.figshare.22362002.v1
title: Identifying novel therapeutic inhibitors to target FMS-like tyrosine kinase-3 (FLT3) against acute myeloid leukemia: a molecular docking, molecular dynamics, and DFT study

description: Around 30% of acute myeloid leukemia (AML) patients have triggering mutations in Feline McDonough Sarcoma (FMS)-like tyrosine kinase 3 (FLT3), which has been suggested as a possible therapeutic candidate for AML therapy. Many tyrosine kinase inhibitors are available and have a wide variety of applications in the treatment of cancer by inhibiting subsequent steps of cell proliferation. Therefore, our study aims to identify effective antileukemic agents against FLT3 gene. Initially, well-known antileukemic drug candidates have been chosen to generate a structure-based pharmacophore model to assist the virtual screening of 217,77,093 compounds from the Zinc database. The final hits compounds were retrieved and evaluated by docking against the target protein, where the top four compounds have been selected for the analysis of ADMET. Based on the density functional theory (DFT), the geometry optimization, frontier molecular orbital (FMO), HOMO-LUMO, and global reactivity descriptor values have been evaluated that confirming a satisfactory profile and reactivity order for the selected candidates. In comparison to control compounds, the docking results revealed that the four compounds had substantial binding energies (-11.1 to −11.5 kcal/mol) with FLT3. The physicochemical and ADMET (adsorption, distribution, metabolism, excretion, toxicity) prediction results corresponded to the bioactive and safe candidates. Molecular dynamics (MD) confirmed the better binding affinity and stability compared to gilteritinib as a potential FLT3 inhibitor. In this study, a computational approach has been performed that found a better docking and dynamics score against target proteins, indicating potent and safe antileukemic agents, furthermore <i>in-vivo</i> and <i>in-vitro</i> investigations are recommended. Communicated by Ramaswamy H. Sarma
DOI: 10.6084/m9.figshare.22691792
title: Comparative analysis of SilA-laccase mediated degradation of ciprofloxacin, norfloxacin and ofloxacin and interpretation of the possible catalytic mechanism

description: Fluoroquinolones (FQs) are the most commonly used antimicrobial drugs and regardless of their advantages in the healthcare sector, the pollution of these antimicrobial drugs in the environment has big concerns about human and environmental health. The presence of these antibiotic drugs even at the lowest concentrations in the environment has resulted in the emergence and spread of antibiotic resistance. Hence, it is necessary to remediate these pollutants from the environment. Previously alkaline laccase (SilA) from <i>Streptomyces ipomoeae</i> has been demonstrated to show degrading potentials against two of the FQs, Ciprofloxacin (CIP) and Norfloxacin (NOR); however, the molecular mechanism was not elucidated in detail. In this study, we have analyzed the possible molecular catalytic mechanism of FQ degrading SilA-laccase for the degradation of the FQs, CIP, NOR and Ofloxacin (OFL) using three-dimensional protein structure modeling, molecular docking and molecular dynamic (MD) studies. The comparative protein sequence analysis revealed the presence of tetrapeptide conserved catalytic motif, His<sup>102</sup>-X-His<sup>104</sup>-Gly<sup>105</sup>. After evaluating the active site of the enzyme in depth using CDD, COACH and S-site tools, we have identified the catalytic triad composed of three conserved amino acid residues, His<sup>102</sup>, Val<sup>103</sup> and Tyr<sup>108</sup> with which ligands interacted during the catalysis process. By analyzing the MD trajectories, it is revealed that the highest degradation potential of SilA is for CIP followed by NOR and OFL. Ultimately, this study provides the possible comparative catalytic mechanism for the degradation of CIP, NOR and OFL by the SilA enzyme. Communicated by Ramaswamy H. Sarma
DOI: 10.6084/m9.figshare.22691792.v1
title: Comparative analysis of SilA-laccase mediated degradation of ciprofloxacin, norfloxacin and ofloxacin and interpretation of the possible catalytic mechanism

description: Fluoroquinolones (FQs) are the most commonly used antimicrobial drugs and regardless of their advantages in the healthcare sector, the pollution of these antimicrobial drugs in the environment has big concerns about human and environmental health. The presence of these antibiotic drugs even at the lowest concentrations in the environment has resulted in the emergence and spread of antibiotic resistance. Hence, it is necessary to remediate these pollutants from the environment. Previously alkaline laccase (SilA) from <i>Streptomyces ipomoeae</i> has been demonstrated to show degrading potentials against two of the FQs, Ciprofloxacin (CIP) and Norfloxacin (NOR); however, the molecular mechanism was not elucidated in detail. In this study, we have analyzed the possible molecular catalytic mechanism of FQ degrading SilA-laccase for the degradation of the FQs, CIP, NOR and Ofloxacin (OFL) using three-dimensional protein structure modeling, molecular docking and molecular dynamic (MD) studies. The comparative protein sequence analysis revealed the presence of tetrapeptide conserved catalytic motif, His<sup>102</sup>-X-His<sup>104</sup>-Gly<sup>105</sup>. After evaluating the active site of the enzyme in depth using CDD, COACH and S-site tools, we have identified the catalytic triad composed of three conserved amino acid residues, His<sup>102</sup>, Val<sup>103</sup> and Tyr<sup>108</sup> with which ligands interacted during the catalysis process. By analyzing the MD trajectories, it is revealed that the highest degradation potential of SilA is for CIP followed by NOR and OFL. Ultimately, this study provides the possible comparative catalytic mechanism for the degradation of CIP, NOR and OFL by the SilA enzyme. Communicated by Ramaswamy H. Sarma
DOI: 10.6084/m9.figshare.22316610
title: Detection of natural compounds by virtual screening, molecular docking and dynamics studies and evaluation of their effects on tau level <i>in vitro</i> Alzheimer’s model

description: In Alzheimer’s disease (AD), neurofibrillary tangles are composed of hyperphosphorylated tau protein, and tau hyperphosphorylation reduces microtubule binding. Many protein kinases are thought to be involved in tau hyperphosphorylation. Based on the fact that tau hyperphosphorylation can be prevented by inhibition of glycogen synthase kinase-3β (GSK-3β), which is one of the tau kinases, the effectiveness of potential GSK-3β inhibitors determined by virtual screening, molecular docking, and dynamics simulations studies on Alzheimer’s pathology has been examined and its role in neurodegeneration has been investigated by studies. Neomangiferin was determined as the most effective molecule according to the results of studies with potential compounds determined by virtual screening and molecular docking to be GSK-3β inhibitors in the <i>in vitro</i> Alzheimer’s model created by neuronal differentiation studies. Neomangiferin has been shown to have a protective role in induced neurodegeneration by the MTT method and Real Time Cell Analysis. It has been determined that Neomangiferin inhibits GSK-3β and reduces the level of phosphorylated tau. In summary, our findings suggested Neomangiferin can be a therapeutic candidate for AD treatment. Communicated by Ramaswamy H. Sarma
DOI: 10.6084/m9.figshare.22316610.v2
title: Detection of natural compounds by virtual screening, molecular docking and dynamics studies and evaluation of their effects on tau level <i>in vitro</i> Alzheimer’s model

description: In Alzheimer’s disease (AD), neurofibrillary tangles are composed of hyperphosphorylated tau protein, and tau hyperphosphorylation reduces microtubule binding. Many protein kinases are thought to be involved in tau hyperphosphorylation. Based on the fact that tau hyperphosphorylation can be prevented by inhibition of glycogen synthase kinase-3β (GSK-3β), which is one of the tau kinases, the effectiveness of potential GSK-3β inhibitors determined by virtual screening, molecular docking, and dynamics simulations studies on Alzheimer’s pathology has been examined and its role in neurodegeneration has been investigated by studies. Neomangiferin was determined as the most effective molecule according to the results of studies with potential compounds determined by virtual screening and molecular docking to be GSK-3β inhibitors in the <i>in vitro</i> Alzheimer’s model created by neuronal differentiation studies. Neomangiferin has been shown to have a protective role in induced neurodegeneration by the MTT method and Real Time Cell Analysis. It has been determined that Neomangiferin inhibits GSK-3β and reduces the level of phosphorylated tau. In summary, our findings suggested Neomangiferin can be a therapeutic candidate for AD treatment. Communicated by Ramaswamy H. Sarma
DOI: 10.6084/m9.figshare.22316610.v1
title: Detection of natural compounds by virtual screening, molecular docking and dynamics studies and evaluation of their effects on tau level <i>in vitro</i> Alzheimer’s model

description: In Alzheimer’s disease (AD), neurofibrillary tangles are composed of hyperphosphorylated tau protein, and tau hyperphosphorylation reduces microtubule binding. Many protein kinases are thought to be involved in tau hyperphosphorylation. Based on the fact that tau hyperphosphorylation can be prevented by inhibition of glycogen synthase kinase-3β (GSK-3β), which is one of the tau kinases, the effectiveness of potential GSK-3β inhibitors determined by virtual screening, molecular docking, and dynamics simulations studies on Alzheimer’s pathology has been examined and its role in neurodegeneration has been investigated by studies. Neomangiferin was determined as the most effective molecule according to the results of studies with potential compounds determined by virtual screening and molecular docking to be GSK-3β inhibitors in the <i>in vitro</i> Alzheimer’s model created by neuronal differentiation studies. Neomangiferin has been shown to have a protective role in induced neurodegeneration by the MTT method and Real Time Cell Analysis. It has been determined that Neomangiferin inhibits GSK-3β and reduces the level of phosphorylated tau. In summary, our findings suggested Neomangiferin can be a therapeutic candidate for AD treatment. Communicated by Ramaswamy H. Sarma
DOI: 10.6084/m9.figshare.22362116
title: Computational analysis and molecular dynamics simulation of high-risk single nucleotide polymorphisms of the <i>ADAM10</i> gene

description: Polymorphisms of the disintegrin and metalloproteinase domain-containing protein 10 (ADAM10) are linked to pathophysiological changes in lung inflammation, cancer, Alzheimer’s disease (AD), encephalopathy, liver fibrosis, and cardiovascular diseases. In this study, we predicted the pathogenicity of <i>ADAM10</i> non-synonymous single nucleotide polymorphisms (nsSNPs) in a wide array of mutation analyzing bioinformatics tools. We retrieved 423 nsSNPs from dbSNP-NCBI for the analysis, and 13 were predicted deleterious by each of the ten tools: SIFT, PROVEAN, CONDEL, PANTHER-PSEP, SNAP2, SuSPect, PolyPhen-2, Meta-SNP, Mutation Assessor and Predict-SNP. Further assessment of amino acid sequences, homology models, conservation profiles, and inter-atomic interactions identified C222G, G361E and C639Y as the most pathogenic mutations. We validated this prediction through structural stability analysis using DUET, I-Mutant Suite, SNPeffect and Dynamut. Molecular dynamics simulations and principal component analysis also indicated considerable instability of the C222G, G361E and C639Y variants. Therefore, these <i>ADAM10</i> nsSNPs could be candidates for diagnostic genetic screening and therapeutic molecular targeting. Communicated by Ramaswamy H. Sarma