cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.8053358
title: Economic burden of relapse/recurrence in patients with major depressive disorder

description: <b>Objective</b>: This study was conducted to determine the incremental healthcare resource utilization (HRU) and costs associated with relapse or recurrence (R/R) in patients with major depressive disorder (MDD) treated with antidepressants (AD) in US clinical practice. <b>Methods</b>: In this retrospective cohort study, adult patients with MDD treated with a branded AD were selected from the Truven Health Analytics MarketScan Databases (January 1, 2004–March 31, 2015). Time to first indicator of R/R was described. Characteristics, HRU, and costs were compared between patients with and without R/R. Among patients with R/R, HRU and costs were also compared between the pre- and post-R/R period. <b>Results</b>: From the 22,236 selected patients, 5,541 had ≥ 1 indicator of R/R and 16,695 did not. The 3-year R/R rate varied between 21.3% and 36.4% based on pattern of AD use (continuous, switch/augmentation, or early discontinuation). Patients with and without R/R presented different characteristics—notably, more intensive prior AD use and a higher comorbidity burden. HRU and costs were high in both patients with and without R/R but substantially higher among those with R/R ($20,590 vs $12,368 per-patient-per-year (PPPY); adjusted difference [aDiff] = $7,037), mainly driven by increased inpatient (IP) services (adjusted incidence rate ratio IP days = 3.95; aDiff IP costs = $3,433 PPPY). Among patients with R/R, emergency department visits, IP days, and IP admissions were over 2-times higher during the post-R/R period and total costs increased by over 50% from $19,267 to $29,419 in the post-R/R period. <b>Conclusions</b>: The economic burden in MDD patients is substantial, but is significantly higher among those who experience R/R.
DOI: 10.6084/m9.figshare.8053358.v2
title: Economic burden of relapse/recurrence in patients with major depressive disorder

description: <b>Objective</b>: This study was conducted to determine the incremental healthcare resource utilization (HRU) and costs associated with relapse or recurrence (R/R) in patients with major depressive disorder (MDD) treated with antidepressants (AD) in US clinical practice. <b>Methods</b>: In this retrospective cohort study, adult patients with MDD treated with a branded AD were selected from the Truven Health Analytics MarketScan Databases (January 1, 2004–March 31, 2015). Time to first indicator of R/R was described. Characteristics, HRU, and costs were compared between patients with and without R/R. Among patients with R/R, HRU and costs were also compared between the pre- and post-R/R period. <b>Results</b>: From the 22,236 selected patients, 5,541 had ≥ 1 indicator of R/R and 16,695 did not. The 3-year R/R rate varied between 21.3% and 36.4% based on pattern of AD use (continuous, switch/augmentation, or early discontinuation). Patients with and without R/R presented different characteristics—notably, more intensive prior AD use and a higher comorbidity burden. HRU and costs were high in both patients with and without R/R but substantially higher among those with R/R ($20,590 vs $12,368 per-patient-per-year (PPPY); adjusted difference [aDiff] = $7,037), mainly driven by increased inpatient (IP) services (adjusted incidence rate ratio IP days = 3.95; aDiff IP costs = $3,433 PPPY). Among patients with R/R, emergency department visits, IP days, and IP admissions were over 2-times higher during the post-R/R period and total costs increased by over 50% from $19,267 to $29,419 in the post-R/R period. <b>Conclusions</b>: The economic burden in MDD patients is substantial, but is significantly higher among those who experience R/R.
DOI: 10.6084/m9.figshare.8053187
title: Papers from NICE public health guidelines matched in Web of Science.csv

description: List of papers cited on NICE public health guidelines which were matched in Web of Science, including reference, guideline in which the reference was identified, country and institutional affiliations, year of publication, discipline and specialty.
DOI: 10.6084/m9.figshare.8053190
title: Circulating levels of inflammatory markers and DNA methylation, an analysis of repeated samples from a population based cohort

description: DNA methylation in blood may adapt to conditions affecting our health, such as inflammation, and multiple studies have identified differential DNA methylation related to smoking, obesity and various diseases. The purpose of this study was to evaluate previously reported, and explore possible new, associations between levels of inflammatory markers and DNA methylation in blood. We used a well-characterized study population consisting of 127 individuals, all of whom were participants in the population-based Västerbotten Intervention Programme cohort and had provided two blood samples, ten years apart. Levels of CRP and 160 other proteins were measured in plasma, and DNA methylation levels (assessed using the 850K Illumina Infinium MethylationEPIC BeadChip) were measured in white blood cell DNA. Associations between CpG methylation and protein levels were estimated using linear mixed models. In the study we were able to confirm the direction for 85 of 102 previously reported protein-methylation associations. Depicting associations in a network allowed us to identify CpG sites with associations to multiple proteins, and ten CpG sites were each associated with three or more inflammatory markers. Furthermore, two genetic regions included nine additional unreported CpG sites that may represent trans-acting methylation sites. Our study supports a complex interaction between DNA methylation and circulating proteins involved in the inflammatory response. The notion of trans-acting methylation sites affecting, or being affected by, the expression of genes on completely different chromosomes should be taken into account when interpreting results from epigenome-wide association studies.
DOI: 10.17633/rd.brunel.8053178
title: Portable compressed binary tCONCOORD trajectory file - 3SOA A

description: tCONCOORD trajectory
DOI: 10.6084/m9.figshare.8053187.v1
title: Papers from NICE public health guidelines matched in Web of Science.csv

description: List of papers cited on NICE public health guidelines which were matched in Web of Science, including reference, guideline in which the reference was identified, country and institutional affiliations, year of publication, discipline and specialty.
DOI: 10.6084/m9.figshare.8053190.v1
title: Circulating levels of inflammatory markers and DNA methylation, an analysis of repeated samples from a population based cohort

description: DNA methylation in blood may adapt to conditions affecting our health, such as inflammation, and multiple studies have identified differential DNA methylation related to smoking, obesity and various diseases. The purpose of this study was to evaluate previously reported, and explore possible new, associations between levels of inflammatory markers and DNA methylation in blood. We used a well-characterized study population consisting of 127 individuals, all of whom were participants in the population-based Västerbotten Intervention Programme cohort and had provided two blood samples, ten years apart. Levels of CRP and 160 other proteins were measured in plasma, and DNA methylation levels (assessed using the 850K Illumina Infinium MethylationEPIC BeadChip) were measured in white blood cell DNA. Associations between CpG methylation and protein levels were estimated using linear mixed models. In the study we were able to confirm the direction for 85 of 102 previously reported protein-methylation associations. Depicting associations in a network allowed us to identify CpG sites with associations to multiple proteins, and ten CpG sites were each associated with three or more inflammatory markers. Furthermore, two genetic regions included nine additional unreported CpG sites that may represent trans-acting methylation sites. Our study supports a complex interaction between DNA methylation and circulating proteins involved in the inflammatory response. The notion of trans-acting methylation sites affecting, or being affected by, the expression of genes on completely different chromosomes should be taken into account when interpreting results from epigenome-wide association studies.
DOI: 10.17633/rd.brunel.8053163
title: Portable compressed binary tCONCOORD trajectory file - 3KK8 A d

description: XTC trajectory
DOI: 10.17633/rd.brunel.8053178.v1
title: Portable compressed binary tCONCOORD trajectory file - 3SOA A

description: tCONCOORD trajectory
DOI: 10.17633/rd.brunel.8053160
title: Portable compressed binary tCONCOORD trajectory file - 3KK8 A

description: XTC trajectory
DOI: 10.17633/rd.brunel.8053142
title: Portable compressed binary tCONCOORD trajectory file - 3KK8 A - T286D

description: tCONCOORD trajectory<br>
DOI: 10.17633/rd.brunel.8053172
title: Portable compressed binary tCONCOORD trajectory file - 3KL8 CH

description: tCONCOORD trajectory
DOI: 10.17633/rd.brunel.8053109
title: Portable compressed binary tCONCOORD trajectory file - 3KK8 A - I101D I281D d

description: tCONCOORD trajectory
DOI: 10.17633/rd.brunel.8053172.v1
title: Portable compressed binary tCONCOORD trajectory file - 3KL8 CH

description: tCONCOORD trajectory
DOI: 10.17633/rd.brunel.8053091
title: Portable compressed binary tCONCOORD trajectory file - 2VN9 A

description: tCONCOORD trajectory
DOI: 10.17633/rd.brunel.8053109.v1
title: Portable compressed binary tCONCOORD trajectory file - 3KK8 A - I101D I281D d

description: tCONCOORD trajectory
DOI: 10.17633/rd.brunel.8053142.v1
title: Portable compressed binary tCONCOORD trajectory file - 3KK8 A - T286D

description: tCONCOORD trajectory<br>
DOI: 10.17633/rd.brunel.8053079
title: Portable compressed binary tCONCOORD trajectory file - 2BDW A

description: tCONCOORD trajectory
DOI: 10.17633/rd.brunel.8053094
title: Portable compressed binary tCONCOORD trajectory file - 2WEL A

description: tCONCOORD trajectory
DOI: 10.17633/rd.brunel.8053043
title: Portable compressed binary MD trajectory file - 3KK8 A dP

description: XTC trajectory
DOI: 10.17633/rd.brunel.8053073
title: Portable compressed binary MD trajectory file - 3KK8 A dT

description: XTC trajectory
DOI: 10.17633/rd.brunel.8053094.v1
title: Portable compressed binary tCONCOORD trajectory file - 2WEL A

description: tCONCOORD trajectory
DOI: 10.17633/rd.brunel.8053034
title: Portable binary run input files - tCONCOORD

description: tCONCOORD TPR input
DOI: 10.17633/rd.brunel.8053016
title: Portable binary run input files - Molecular Dynamics

description: GROMACS TPR input
DOI: 10.17633/rd.brunel.8053034.v1
title: Portable binary run input files - tCONCOORD

description: tCONCOORD TPR input
DOI: 10.17633/rd.brunel.8053016.v1
title: Portable binary run input files - Molecular Dynamics

description: GROMACS TPR input
DOI: 10.6084/m9.figshare.8052893
title: Effect of integrin AV and B8 gene polymorphisms in patients with traumatic brain injury

description: <b>Background:</b> Α few genetic variants are associated with the outcome after traumatic brain injury (TBI). Integrins are glycoprotein receptors that play an important role in the integrity of microvasculature of the brain. <b>Objective:</b> To examine the role of integrin-AV (<i>ITGAV</i>) and integrin-B8 (<i>ITGB8</i>) tag single nucleotide polymorphisms (SNPs) on the outcome of patients with TBI. <b>Methods:</b> 363 participants were included and genotyped for 11 SNPs for <i>ITGAV</i> and 11 for <i>ITGB8</i> gene. SNPs were tested for associations with the 6-month outcome after TBI, the presence of a hemorrhagic event after TBI, and the initial TBI severity after adjustment for TBI’s main predictors. <b>Results:</b> The ITGAV <i>rs3911239</i> CC and <i>rs7596996</i> GG genotypes were associated with an unfavorable outcome after TBI, compared to the TT and AA genotypes, respectively. The ITGB8 <i>rs10239099</i> CC and <i>rs3757727</i> CC genotypes were associated with increased risk of any cerebral hemorrhagic event after TBI compared to GG and TT respectively. The ITGAV <i>rs7589470</i> and <i>rs7565633</i> were associated with the TBI’s initial severity. <b>Conclusions:</b> ITGAV gene SNPs may be implicated in the outcome after TBI, as well as in the initial TBI severity, and also of ITGB8 gene SNPs in the risk of hemorrhagic event after a TBI.
DOI: 10.6084/m9.figshare.8052893.v1
title: Effect of integrin AV and B8 gene polymorphisms in patients with traumatic brain injury

description: <b>Background:</b> Α few genetic variants are associated with the outcome after traumatic brain injury (TBI). Integrins are glycoprotein receptors that play an important role in the integrity of microvasculature of the brain. <b>Objective:</b> To examine the role of integrin-AV (<i>ITGAV</i>) and integrin-B8 (<i>ITGB8</i>) tag single nucleotide polymorphisms (SNPs) on the outcome of patients with TBI. <b>Methods:</b> 363 participants were included and genotyped for 11 SNPs for <i>ITGAV</i> and 11 for <i>ITGB8</i> gene. SNPs were tested for associations with the 6-month outcome after TBI, the presence of a hemorrhagic event after TBI, and the initial TBI severity after adjustment for TBI’s main predictors. <b>Results:</b> The ITGAV <i>rs3911239</i> CC and <i>rs7596996</i> GG genotypes were associated with an unfavorable outcome after TBI, compared to the TT and AA genotypes, respectively. The ITGB8 <i>rs10239099</i> CC and <i>rs3757727</i> CC genotypes were associated with increased risk of any cerebral hemorrhagic event after TBI compared to GG and TT respectively. The ITGAV <i>rs7589470</i> and <i>rs7565633</i> were associated with the TBI’s initial severity. <b>Conclusions:</b> ITGAV gene SNPs may be implicated in the outcome after TBI, as well as in the initial TBI severity, and also of ITGB8 gene SNPs in the risk of hemorrhagic event after a TBI.
DOI: 10.6084/m9.figshare.8052884
title: Benevento_etal_dataset_ESM from Patterns of mammalian jaw ecomorphological disparity during the Mesozoic/Cenozoic transition

description: A .cvs file including species names, specimen numbers, locality information, and PCA scores for each taxa included in this study
DOI: 10.17637/rh.8052881
title: Data set for Gange et al metanalysis of plant bodyguards, New Phytologist 2019

description: The file lists all 527 studies of insect herbivore responses to the presence of endophytic fungi within plant tissues. Each study has the sample size plus the calculated values of Hedges' d from the analysis.<br>
DOI: 10.6084/m9.figshare.8052884.v1
title: Benevento_etal_dataset_ESM from Patterns of mammalian jaw ecomorphological disparity during the Mesozoic/Cenozoic transition

description: A .cvs file including species names, specimen numbers, locality information, and PCA scores for each taxa included in this study
DOI: 10.17637/rh.8052881.v1
title: Data set for Gange et al metanalysis of plant bodyguards, New Phytologist 2019

description: The file lists all 527 studies of insect herbivore responses to the presence of endophytic fungi within plant tissues. Each study has the sample size plus the calculated values of Hedges' d from the analysis.<br>
DOI: 10.6084/m9.figshare.8052788
title: Sediment bacteria in Lugu Lake

description: Understanding biodiversity patterns and the role of biotic attributes in governing these patterns remains one of the most important challenges in ecology. Here, taking water depth in Lake Lugu as a typical geographical gradient, we studied how these different taxa, that is bacteria, diatoms and chironomids, respond to the same depth and environmental gradients using molecular and morphological methods. We further evaluated the relative importance of water depth, environmental variables and biotic attributes in explaining biological characteristics, such as biomass, species richness and community composition. The biomass of chironomids and the richness of bacteria and chironomids both showed a nonlinearly decreasing pattern associated with water depth, while biomass and species richness of diatoms showed U-shaped and hump-shaped patterns, respectively. The three taxonomic groups all showed increasing dissimilarity with water depth changes, and there was clear cross-taxon congruence among the variations in community composition. Abiotic variables were pivotal in structuring biological characteristics; however, the biotic attributes also explained a unique portion of their variations. This suggests that biotic interactions significantly influenced the patterns of biomass, species richness and community compositions along the water depth gradients for the three taxonomic groups studied. Our results provide new evidence that biotic attributes could help in predicting the biodiversity of aquatic communities along geographical gradients, such as water depth gradients.
DOI: 10.6084/m9.figshare.8052779
title: Reflectance spectra of lizard colours and substrates from Risk of social colours in an agamid lizard: implications for the evolution of dynamic signals

description: Reflectance spectra of colours expressed by male and female P. dorsalis and of substrates used for visual modelling
DOI: 10.6084/m9.figshare.8052782
title: Data from field experiments from Risk of social colours in an agamid lizard: implications for the evolution of dynamic signals

description: Data from field experiments on predator attacks on the lizard wax models
DOI: 10.6084/m9.figshare.8052953.v3
title: Subject Raw Data

description: Raw data from subjects in the passive group (001-012) and active group (013-024) in a concurrent TMS-EEG study investigating natural frequencies.
DOI: 10.6084/m9.figshare.8052779.v1
title: Reflectance spectra of lizard colours and substrates from Risk of social colours in an agamid lizard: implications for the evolution of dynamic signals

description: Reflectance spectra of colours expressed by male and female P. dorsalis and of substrates used for visual modelling
DOI: 10.6084/m9.figshare.8052782.v1
title: Data from field experiments from Risk of social colours in an agamid lizard: implications for the evolution of dynamic signals

description: Data from field experiments on predator attacks on the lizard wax models
DOI: 10.6084/m9.figshare.8052725
title: Genome-wide detection of genetic loci and candidate genes for teat number and conformation traits at birth in Chinese Sushan pigs

description: The phenotypes and genotypes for Sushan pigs
DOI: 10.6084/m9.figshare.8052953.v5
title: Subject Raw Data

description: Raw data from subjects in the passive group (001-012) and active group (013-024) in a concurrent TMS-EEG study investigating natural frequencies.
DOI: 10.6084/m9.figshare.8052953.v6
title: Subject Raw Data

description: Raw data from subjects in the passive group (001-012) and active group (013-024) in a concurrent TMS-EEG study investigating natural frequencies.
DOI: 10.6084/m9.figshare.8052953.v7
title: Subject Raw Data

description: Raw data from subjects in the passive group (001-012) and active group (013-024) in a concurrent TMS-EEG study investigating natural frequencies.
DOI: 10.6084/m9.figshare.8052953
title: Subject Raw Data

description: Raw data from subjects in the passive group (001-012) and active group (013-024) in a concurrent TMS-EEG study investigating natural frequencies. [See Readme.txt file for details.]
DOI: 10.17870/bathspa.8052602
title: Mbira Hut Project - Chartwell Dutiro - Interview with Museum of Contemporary Cuts

description: Click the below link to view the full interview:<br>https://vimeo.com/176602346<br>This item relates to the PhD research of Chartwell Dutiro at Bath Spa University, the Mbira Hut Project. <br><br>Chartwell Dutiro is a musician-singer-songwriter-composer-teacher also founder and Artistic Director of Mhararano Mbira Academy. Mbira is an ancient mystic traditional musical instrument from Zimbabwe. It is sometimes played in all night ritual ceremonies called Bira. For centuries Shona people of Zimbabwe have always believe in connecting with the ancestral spirits for daily guidance. Mbira music is the lynch pin between the Shaman/Spirit medium and the spirits of the ancestors.Chartwell now living in UK grew up in Zimbabwe. From the age of 4 he was already playing mbira for all night ritual ceremonies and publicperformances,and is now regarded as a World-Class Mbira player. He uses the instrument as an education tool,to encompass both traditional and contemporary perspectives,challenge stereotypes and encourage creative engagement.<br>Chartwell draws on his experience of growing up in rural segregated Zimbabwe to build bridges between cultures and make links between contemporary Zimbabwe and life in Britain and around the world today.Chartwell Dutiro holds a Masters degree in Ethnomusicology from SOAS University of London. Currently is a Visiting Research Fellow at Bath Spa University in UK. For more info:chartwellusa.wordpress.com<br>Black Sheep Talks is a series of podcast interviews with artists, academics, and activists across the globe who self-define with the concept of the black sheep. Conceived by Lanfranco Aceti and realized in collaboration with Sarah Bradshaw and Rosemary Bucher, students of Arts Administration – the interviews showcase conceptual innovators at the forefront of their respective fields, challenging and blurring the stereotypical notions of boundaries and success while enveloping elements of contemporary issues. Black Sheep Talks is a production of Arts Administration @ Boston University and the Museum of Contemporary Cuts (MoCC).
DOI: 10.6084/m9.figshare.8052605
title: Intelligent walking of humans and robots

description: The data underlying results contain the first exposures (first trial) of dependent variables of interest, including spatiotemporal, kinematic and kinetic parameters arranged for two-way repeated-measurement ANOVAs using two within-subjects factors: (1) velocity (comfortable and fast), and (2) stepdown (X0<sub>ST</sub>, X10<sub>ST</sub>, X20<sub>ST</sub>, and UX10<sub>ST</sub>). X0<sub>ST</sub>, X10<sub>ST</sub> and X20<sub>ST</sub>, expected stepdown of 0-, ˗10- and ˗20-cm, respectively; UX10<sub>ST</sub>, ˗10-cm unexpected stepdown.