cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.7284/119712
title: GNSS (Global Navigation Satellite System) data collected during research cruise NH1501 using a Furuno GP-150 instrument system onboard the platform RV New Horizon

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7419260.v1
title: Growth and production of volatile compounds of yarrow (Achillea millefolium L.) under different irrigation depths

description: Abstract Yarrow (Achillea millefolium L., Asteraceae) is an important medicinal plant used worldwide for its medicinal properties such as the analgesic, antioxidant and anti-inflammatory ones. The aim of this study was to evaluate the growth and production of photosynthetic pigments and of volatile constituents of Achillea millefolium L. under different irrigation depths. The treatments were the application of 55, 110, 220, 440 and 880 mm of water for a period of 110 days. Data were submitted to polynomial regression analysis at 5% probability, while the volatile constituents were analyzed by standard deviation. Different irrigation depths provided quadratic growth responses being the highest dry matter production at the depth of 440 mm. The contents of chlorophyll a, b, total and carotenoids were higher at the lower depth tested (55 mm). The major volatile compounds identified were sabinene, 1,8-cineol, borneol and β-caryophyllene. Increased water availability reduced the complexity of the volatile fraction of essential oil. Thus, it is recommended that the species be cultivated at 440 mm irrigation depth to have a higher production of dry matter and lower variation in the volatile profile of the essential oil.
DOI: 10.6084/m9.figshare.7419254
title: Who they are, what they do, and how they interact: understanding stakeholders in Small Hydropower Plants

description: Abstract The use of energy and the different strategies of diffusion and implementation of new energy technologies involve multiple stakeholders who have distinct roles, interests, values, and beliefs. In this context, this study seeks to identify and understand how stakeholders involved in Small Hydropower Plants act and which roles they play based on an qualitative research. Primary data were collected from semi-structured interviews applied to nine representatives of different groups of stakeholders. Secondary data were collected through documentary research, observing the sector legislation, reports, edicts, and instructions available on the websites of government entities and regulatory agencies. Data on stakeholders were assessed by content analysis in three categories: a) who they are; b) what they do; and c) how they interact during the stages of implementation of a small hydropower plant. Seven stakeholder groups and nineteen members that represent them were identified. The following groups of stakeholders were identified: (1) Institutional Agents; (2) Non-governmental organizations; (3) Renewable energy investors and producers; (4) Investment banks; (5) Suppliers of the sector; (6) Associations for renewable energy development; and (7) Local stakeholders. In addition, there is a description of the five stages of implementation of renewable energy projects and how those groups interact in each of them. The results show a lack of collaboration and dialogue between the different stakeholders when deciding about resource management, as well as lack of information leading to loss of confidence of local stakeholders in the projects before their installation and throughout their life cycle. As a contribution, this study points out that, once the stages of implementation and the actors involved have been identified, new forms of communication can be proposed to increase information transparency, as well as workflow models that attempt to collaborate and dialogue with the different stakeholders.
DOI: 10.6084/m9.figshare.7419257
title: Efficacy of sertraline against Trypanosoma cruzi: an in vitro and in silico study

description: Abstract Background: Drug repurposing has been an interesting and cost-effective approach, especially for neglected diseases, such as Chagas disease. Methods: In this work, we studied the activity of the antidepressant drug sertraline against Trypanosoma cruzi trypomastigotes and intracellular amastigotes of the Y and Tulahuen strains, and investigated its action mode using cell biology and in silico approaches. Results: Sertraline demonstrated in vitro efficacy against intracellular amastigotes of both T. cruzi strains inside different host cells, including cardiomyocytes, with IC50 values between 1 to 10 μM, and activity against bloodstream trypomastigotes, with IC50 of 14 μM. Considering the mammalian cytotoxicity, the drug resulted in a selectivity index of 17.8. Sertraline induced a change in the mitochondrial integrity of T. cruzi, resulting in a decrease in ATP levels, but not affecting reactive oxygen levels or plasma membrane permeability. In silico approaches using chemogenomic target fishing, homology modeling and molecular docking suggested the enzyme isocitrate dehydrogenase 2 of T. cruzi (TcIDH2) as a potential target for sertraline. Conclusions: The present study demonstrated that sertraline had a lethal effect on different forms and strains of T. cruzi, by affecting the bioenergetic metabolism of the parasite. These findings provide a starting point for future experimental assays and may contribute to the development of new compounds.
DOI: 10.6084/m9.figshare.7419266.v1
title: Vascular epiphyte biomass in a South Brazilian fragment of Atlantic Forest

description: Abstract The present study aimed at sampling the biomass of vascular epiphytes within a protected area in South Brazilian Atlantic Forest. All tree specimens with diameter at breast height equal or greater than 4.8 cm were measured and divided into classes. In each class, 10% of tree specimens were randomly selected for epiphytic biomass measuring. Furthermore, we divided the phorophytes into five tree parts to analyze epiphytic biomass. We generated mathematical models to estimate epiphytic biomass in similar forest areas. We analyzed 55 phorophytes and found an estimated epiphytic biomass of 5.3 Mg/ha. Epiphytic biomass ranged from 0.02 to 135 kg and the lower values were found on small-sized phorophytes. Higher values of epiphytic biomass were found on phorophytes with diameter at breast height between 30 and 36.5 cm. The tree part with higher epiphytic biomass was the outer crown. The epiphytic biomass showed a high correlation with phorophyte diameter, according to the mathematical models. We selected two equations which presented the most similar values to the ones we measured. Our results corroborate that epiphytes play a very important role as to the biomass level within tropical forests.
DOI: 10.6084/m9.figshare.7419251
title: Activity of the antiarrhythmic drug amiodarone against Leishmania (L.) infantum: an in vitro and in vivo approach

description: Abstract Background: Considering the high toxicity and limited therapies available for treating visceral leishmaniasis (VL), the drug repositioning approach represents a faster way to deliver new therapies to the market. Methods: In this study, we described for the first time the activity of a potent antiarrhythmic, amiodarone (AMD), against L. (L.)infantum and its in vitro and in vivo activity. Results: The evaluation against promastigotes has shown that amiodarone presents leishmanicidal effect against the extracellular form, with an IC50 value of 10 μM. The activity was even greater against amastigotes in comparison with promastigotes with an IC50 value of 0.5 μM. The selectivity index in relation to the intracellular form demonstrated that the antiparasitic activity was approximately 56 times higher than its toxicity to mammalian cells. Investigation of the in vivo AMD activity in the L. infantum-infected hamster model showed that 51 days after the initial infection, amiodarone was unable to reduce the parasite burden in the spleen and liver when treated for 10 consecutive days, intraperitoneally, at 50 mg/kg/day, as determined by qPCR. Although not statistically significant, AMD was able to reduce the parasite burden by 20% in the liver when treated for 10 consecutive days, orally, at 100 mg/kg/day; no reduction in the spleen was found by qPCR. Conclusions: Our findings may help further drug design studies seeking new AMD derivatives that may provide new candidates with an in vitro selectivity close to or even greater than that observed in the prototype delivering effectiveness in the experimental model of VL.
DOI: 10.6084/m9.figshare.7419257.v1
title: Efficacy of sertraline against Trypanosoma cruzi: an in vitro and in silico study

description: Abstract Background: Drug repurposing has been an interesting and cost-effective approach, especially for neglected diseases, such as Chagas disease. Methods: In this work, we studied the activity of the antidepressant drug sertraline against Trypanosoma cruzi trypomastigotes and intracellular amastigotes of the Y and Tulahuen strains, and investigated its action mode using cell biology and in silico approaches. Results: Sertraline demonstrated in vitro efficacy against intracellular amastigotes of both T. cruzi strains inside different host cells, including cardiomyocytes, with IC50 values between 1 to 10 μM, and activity against bloodstream trypomastigotes, with IC50 of 14 μM. Considering the mammalian cytotoxicity, the drug resulted in a selectivity index of 17.8. Sertraline induced a change in the mitochondrial integrity of T. cruzi, resulting in a decrease in ATP levels, but not affecting reactive oxygen levels or plasma membrane permeability. In silico approaches using chemogenomic target fishing, homology modeling and molecular docking suggested the enzyme isocitrate dehydrogenase 2 of T. cruzi (TcIDH2) as a potential target for sertraline. Conclusions: The present study demonstrated that sertraline had a lethal effect on different forms and strains of T. cruzi, by affecting the bioenergetic metabolism of the parasite. These findings provide a starting point for future experimental assays and may contribute to the development of new compounds.
DOI: 10.7284/119713
title: GNSS (Global Navigation Satellite System) data collected during research cruise NH1501 using a Garmin GPS-17HVS instrument system onboard the platform RV New Horizon

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7419251.v1
title: Activity of the antiarrhythmic drug amiodarone against Leishmania (L.) infantum: an in vitro and in vivo approach

description: Abstract Background: Considering the high toxicity and limited therapies available for treating visceral leishmaniasis (VL), the drug repositioning approach represents a faster way to deliver new therapies to the market. Methods: In this study, we described for the first time the activity of a potent antiarrhythmic, amiodarone (AMD), against L. (L.)infantum and its in vitro and in vivo activity. Results: The evaluation against promastigotes has shown that amiodarone presents leishmanicidal effect against the extracellular form, with an IC50 value of 10 μM. The activity was even greater against amastigotes in comparison with promastigotes with an IC50 value of 0.5 μM. The selectivity index in relation to the intracellular form demonstrated that the antiparasitic activity was approximately 56 times higher than its toxicity to mammalian cells. Investigation of the in vivo AMD activity in the L. infantum-infected hamster model showed that 51 days after the initial infection, amiodarone was unable to reduce the parasite burden in the spleen and liver when treated for 10 consecutive days, intraperitoneally, at 50 mg/kg/day, as determined by qPCR. Although not statistically significant, AMD was able to reduce the parasite burden by 20% in the liver when treated for 10 consecutive days, orally, at 100 mg/kg/day; no reduction in the spleen was found by qPCR. Conclusions: Our findings may help further drug design studies seeking new AMD derivatives that may provide new candidates with an in vitro selectivity close to or even greater than that observed in the prototype delivering effectiveness in the experimental model of VL.
DOI: 10.6084/m9.figshare.7419254.v1
title: Who they are, what they do, and how they interact: understanding stakeholders in Small Hydropower Plants

description: Abstract The use of energy and the different strategies of diffusion and implementation of new energy technologies involve multiple stakeholders who have distinct roles, interests, values, and beliefs. In this context, this study seeks to identify and understand how stakeholders involved in Small Hydropower Plants act and which roles they play based on an qualitative research. Primary data were collected from semi-structured interviews applied to nine representatives of different groups of stakeholders. Secondary data were collected through documentary research, observing the sector legislation, reports, edicts, and instructions available on the websites of government entities and regulatory agencies. Data on stakeholders were assessed by content analysis in three categories: a) who they are; b) what they do; and c) how they interact during the stages of implementation of a small hydropower plant. Seven stakeholder groups and nineteen members that represent them were identified. The following groups of stakeholders were identified: (1) Institutional Agents; (2) Non-governmental organizations; (3) Renewable energy investors and producers; (4) Investment banks; (5) Suppliers of the sector; (6) Associations for renewable energy development; and (7) Local stakeholders. In addition, there is a description of the five stages of implementation of renewable energy projects and how those groups interact in each of them. The results show a lack of collaboration and dialogue between the different stakeholders when deciding about resource management, as well as lack of information leading to loss of confidence of local stakeholders in the projects before their installation and throughout their life cycle. As a contribution, this study points out that, once the stages of implementation and the actors involved have been identified, new forms of communication can be proposed to increase information transparency, as well as workflow models that attempt to collaborate and dialogue with the different stakeholders.
DOI: 10.6084/m9.figshare.7419245
title: Antiprotozoal action of synthetic cinnamic acid analogs

description: Abstract INTRODUCTION Leishmaniasis, Chagas disease, and malaria cause morbidity globally. The drugs currently used for treatment have limitations. Activity of cinnamic acid analogs against Leishmania spp., Trypanosoma cruzi, and Plasmodium falciparum was evaluated in the interest of identifying new antiprotozoal compounds. METHODS In vitro effects of analogs against L. braziliensis, L. infantum chagasi, T. cruzi, and P. falciparum, and hemolytic and cytotoxic activities on NCTC 929 were determined. RESULTS Three analogs showed leishmanicidal and tripanocidal activity. No antiplasmodial, hemolytic, or cytotoxic activity was observed. CONCLUSIONS Antiprotozoal activity of analogs against L. infantum braziliensis, L. infantum chagasi, and T. cruzi was demonstrated.
DOI: 10.6084/m9.figshare.7419245.v1
title: Antiprotozoal action of synthetic cinnamic acid analogs

description: Abstract INTRODUCTION Leishmaniasis, Chagas disease, and malaria cause morbidity globally. The drugs currently used for treatment have limitations. Activity of cinnamic acid analogs against Leishmania spp., Trypanosoma cruzi, and Plasmodium falciparum was evaluated in the interest of identifying new antiprotozoal compounds. METHODS In vitro effects of analogs against L. braziliensis, L. infantum chagasi, T. cruzi, and P. falciparum, and hemolytic and cytotoxic activities on NCTC 929 were determined. RESULTS Three analogs showed leishmanicidal and tripanocidal activity. No antiplasmodial, hemolytic, or cytotoxic activity was observed. CONCLUSIONS Antiprotozoal activity of analogs against L. infantum braziliensis, L. infantum chagasi, and T. cruzi was demonstrated.
DOI: 10.7284/119714
title: GNSS (Global Navigation Satellite System) data collected during research cruise NH1501 using a Ashtech ADU2 instrument system onboard the platform RV New Horizon

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/119715
title: GNSS (Global Navigation Satellite System) data collected during research cruise NH1501 using a Furuno GP-90D instrument system onboard the platform RV New Horizon

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7419224
title: Absorptive capacity, exploration, and exploitation: an analysis of the companies in Palmas, Tocantins

description: Abstract This research is about the relationship between the exploitation, exploration, and absorptive capacity of the organizational knowledge. The three themes are of great importance to the sustainable competitive advantage of organizations. In general, although they are inserted in the discussion of organizational learning, they are still in the evolutionary process regarding antecedents, moderators, and outcomes, as can be observed in the theoretical reference. It has not been possible to identify studies with similar characteristics as the one presented here, i.e., studies linking exploration and exploitation with absorptive capacity, particularly in the Brazilian context. The main objective was to evaluate the degree of association between exploration, exploitation, and absorptive capacity. This study used quantitative research in 100 companies operating in commerce and services sectors, all located in the city of Palmas, Tocantins State. The sector was chosen based on the concentration of commercial and services companies in the city. The informants were the managers who worked in these companies. The questionnaire involved the use of two scales: one scale for the measurement of exploration and exploitation, and the other scale for measuring the absorptive capacity, both validated by early studies. The technique involved structural equation modeling using Partial Least Square-Path Modeling (PLS-PM) software was used for the verification of the principal hypothesis. The concepts of exploration and exploitation were based on six dimensions: organizational knowledge practices, innovation practices, strategic orientation, competition, partnerships, and efficiency. The concept of absorptive capacity was based on four dimensions: porosity, routines and structures, public knowledge, and individual abilities. The results showed that companies had exploitation orientation. Regarding the absorptive capacity, companies had a high relationship with the environment, with routines and with procedures, and with public knowledge. The main hypothesis was confirmed, indicating a positive relationship between exploration, exploitation, and absorptive capacity.
DOI: 10.7284/119718
title: Gyrocompass data collected during research cruise NH1501 using a Sperry MK-37 instrument system onboard the platform RV New Horizon

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7419221
title: Evolução do Pronaf Crédito no Período 1996-2013: redimensionando o acesso pelos cadastros de pessoa física

description: Abstract: The analysis about the National Program for Strengthening Family Agriculture (Pronaf) in Brazil generally mobilize the amounts applied and the number of contracts as quantitative performance indicators. The empirical evidence points to a great overlap in this indicator, the existence of family establishments (EF) with more than one Pronaf contract in the same year. The present study uses the indicator of the beneficiary’s CPF (Individual Taxpayer Registration Number) to demonstrate that access is well below that indicated by the number of contracts. In 2013, 2,099,279 Pronaf contracts, equivalent to 48% of the EF registered in the 2006 Census of Agriculture, were computed. When access is measured by the CPF, this number drops to 1,154,613 insured persons, which is equivalent to only 26% of the registered in terms of concentration of resources, the average value financed by the CPF registered strong growth in relation to 2008, which is partially hidden if the indicator IS the average value of the contracts. It is concluded that the evaluation of the effectiveness of Pronaf based on the number of CPFs is more precise than the number of contracts, constituting a relevant indicator to improve the analysis of its social reach.
DOI: 10.6084/m9.figshare.7419221.v1
title: Evolução do Pronaf Crédito no Período 1996-2013: redimensionando o acesso pelos cadastros de pessoa física

description: Abstract: The analysis about the National Program for Strengthening Family Agriculture (Pronaf) in Brazil generally mobilize the amounts applied and the number of contracts as quantitative performance indicators. The empirical evidence points to a great overlap in this indicator, the existence of family establishments (EF) with more than one Pronaf contract in the same year. The present study uses the indicator of the beneficiary’s CPF (Individual Taxpayer Registration Number) to demonstrate that access is well below that indicated by the number of contracts. In 2013, 2,099,279 Pronaf contracts, equivalent to 48% of the EF registered in the 2006 Census of Agriculture, were computed. When access is measured by the CPF, this number drops to 1,154,613 insured persons, which is equivalent to only 26% of the registered in terms of concentration of resources, the average value financed by the CPF registered strong growth in relation to 2008, which is partially hidden if the indicator IS the average value of the contracts. It is concluded that the evaluation of the effectiveness of Pronaf based on the number of CPFs is more precise than the number of contracts, constituting a relevant indicator to improve the analysis of its social reach.
DOI: 10.6084/m9.figshare.7419215
title: Molecular detection of vector borne pathogens in anemic and thrombocytopenic dogs in southern Brazil

description: Abstract Arthropod-borne pathogens are medically important because of their ability to cause diseases in their hosts. The purpose of this study was to detect the occurrence of Ehrlichia spp., piroplasmids and Hepatozoon spp. in dogs with anemia and thrombocytopenia in southern Brazil. EDTA-whole blood was collected from 75 domestic dogs presenting anemia or/and thrombocytopenia from Guarapuava, state of Paraná, Brazil. DNA samples were subjected to conventional PCR assays for Ehrlichia spp. (dsb), piroplasmids (18S rRNA) and Hepatozoon spp. (18S rRNA), followed by sequencing and phylogenetic analyses. Among the 75 dogs, one (1.33%) was positive for Hepatozoon sp. and six (8%) were positive for piroplasmids in 18S rRNA cPCR assays. None of the dogs showed positive results in Ehrlichia spp.-cPCR targeting dsb gene. The phylogenetic analyses revealed that three piroplasm sequences were clustered with Rangellia vitalii, while one sequence was grouped with B. vogeli. The only sequence obtained from Hepatozoon spp.-PCR protocol was pooled with H. canis. Therefore, there is urgent need for differential molecular diagnosis of the two piroplasm species cited as etiological agents in clinical cases of canine hemoparasitic diseases, given the higher pathogenic potential of R. vitalii than of B. vogeli.
DOI: 10.7284/119717
title: Meteorological Station data collected during research cruise NH1501 using a SIO MET-System instrument system onboard the platform RV New Horizon

description: Original (unprocessed) data collected during a Field_expedition