cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.8427107.v1
title: Women in Latin American science: gender parity in the twenty-first century and prospects for a post-war Colombia

description: The aim of this study was to evaluate the status of gender parity in science in Colombia throughout the twenty-first century. Data were decomposed by research area, researcher rank level and academic level. Gender disparity was also estimated for changes in average age, access to scholarships for postgraduate studies, and number of doctoral graduates. Using logistic function modeling, temporal projections into the future were performed in order to estimate how long could it take to reach gender parity. Medical and health science is the only field to have reached gender parity, while also showing a steady decrease in women’s representation across time. On the other hand, engineering, humanities and natural sciences had the lowest percentages of women’s representation. Women researchers showed a decreasing presence as they move upward to more senior levels, exemplifying the “leaky-pipeline phenomenon” common in science. Possible drivers of these results are analyzed, suggesting that a combination of lack of research funding, insufficient legal framework, pre-existing biases, and poor protection of women’s rights inhibits women’s participation in science. It is estimated that, without any action to change current trends, it could take between 10 (humanities) and 150 (engineering) years to reach gender parity across all research areas.
DOI: 10.6084/m9.figshare.8427071.v2
title: Global modulation in DNA epigenetics during pro-inflammatory macrophage activation

description: DNA methylation patterns create distinct gene-expression profiles. These patterns are maintained after cell division, thus enabling the differentiation and maintenance of multiple cell types from the same genome sequence. The advantage of this mechanism for transcriptional control is that chemical-encoding allows to rapidly establish new epigenetic patterns ‘<i>on-demand</i>’ through enzymatic methylation and demethylation of DNA. Here we show that this feature is associated with the fast response of macrophages during their pro-inflammatory activation. By using a combination of mass spectroscopy and single-molecule imaging to quantify global epigenetic changes in the genomes of primary macrophages, we followed three distinct DNA marks (methylated, hydroxymethylated and unmethylated), involved in establishing new DNA methylation patterns during pro-inflammatory activation. The observed epigenetic modulation together with gene-expression data generated for the involved enzymatic machinery may suggest that de-methylation upon LPS-activation starts with oxidation of methylated CpGs, followed by excision-repair of these oxidized bases and their replacement with unmodified cytosine.
DOI: 10.6084/m9.figshare.8427062
title: Evaluation of vaccine delivery systems for inducing long-lived antibody responses to <i>Dermanyssus gallinae</i> antigen in laying hens

description: <i>Dermanyssus gallinae</i>, the poultry red mite, is a global threat to the commercial egg-laying industry. Control of <i>D. gallinae</i> is difficult, with only a limited number of effective pesticides and non-chemical treatments available. Here, we characterize the candidate vaccine antigen <i>D. gallinae</i> cathepsin D-1 (Dg-CatD-1) and demonstrate that purified refolded recombinant Dg-Cat-D1 (rDg-CatD-1) is an active aspartyl proteinase which digests haemoglobin with a pH optimum of pH 4. Soluble protein extracts from <i>D. gallinae</i> also have haemoglobinase activity, with a pH optimum comparable to the recombinant protein, and both proteinase activities were inhibited by the aspartyl proteinase inhibitor Pepstatin A. Enzyme activity and the ubiquitous localization of Dg-CatD-1 protein in sections of adult female mites is consistent with Dg-CatD-1 being a lysosomal proteinase. Using Dg-CatD-1 as a model vaccine antigen, we compared vaccine delivery methods in laying hens via vaccination with: (i) purified rDg-CatD-1 with Montanide™ ISA 71 VG adjuvant; (ii) recombinant DNA vaccines for expression of rDg-CatD-1 and (iii) transgenic coccidial parasite <i>Eimeria tenella</i> expressing rDg-CatD-1. In two independent trials, only birds vaccinated with rDg-CatD-1 with Montanide™ ISA 71 VG produced a strong and long-lasting serum anti-rDg-Cat-D1 IgY response, which was significantly higher than that in control birds vaccinated with adjuvant only. Furthermore, we showed that egg-laying rates of <i>D. gallinae</i> mites fed on birds vaccinated with rDg-CatD-1 in Montanide™ ISA 71 VG was reduced significantly compared with mites fed on unvaccinated birds. <b>RESEARCH HIGHLIGHTS</b><i>Dermanyssus gallinae</i> cathepsin D-1 (Dg-CatD-1) digests haemoglobinVaccination of hens with rDg-CatD-1 in Montanide™ ISA 71 VG results in long-lasting IgY levelsSerum anti-rDg-CatD-1 antibodies reduce egg laying in <i>D. gallinae</i> after a single blood meal <i>Dermanyssus gallinae</i> cathepsin D-1 (Dg-CatD-1) digests haemoglobin Vaccination of hens with rDg-CatD-1 in Montanide™ ISA 71 VG results in long-lasting IgY levels Serum anti-rDg-CatD-1 antibodies reduce egg laying in <i>D. gallinae</i> after a single blood meal
DOI: 10.6084/m9.figshare.8427071.v1
title: Global Modulation in DNA Epigenetics during Pro-Inflammatory Macrophage Activation

description: DNA methylation patterns create distinct gene expression profiles. These patterns are maintained after cell division, thus enabling the differentiation and maintenance of multiple cell types from the same genome sequence. The advantage of this mechanism for transcriptional control is that chemical-encoding allows to rapidly establish new epigenetic patterns “<i>on-demand</i>” through enzymatic methylation and de-methylation of DNA. Here we show that this feature is associated with the fast response of macrophages during their pro-inflammatory activation. By using a combination of mass spectroscopy and single-molecule imaging to quantify global epigenetic changes in the genomes of primary macrophages, we followed three distinct DNA marks (methylated, hydroxymethylated and unmethylated), involved in establishing new DNA methylation patterns during pro-inflammatory activation. The observed epigenetic modulation together with gene expression data generated for the involved enzymatic machinery, may suggest that de-methylation upon LPS-activation starts with oxidation of methylated CpGs, followed by excision-repair of these oxidized bases and their replacement with unmodified cytosine.
DOI: 10.6084/m9.figshare.8427044
title: Just Fuzz It: Solving Floating-point Constraints Using Coverage-guided Fuzzing

description: This is the artifact for our FSE 2019 paper titled "Just Fuzz It: Solving Floating-point Constraints Using Coverage-guided Fuzzing".<br>The corresponding git repository for this can be found at https://github.com/mc-imperial/jfs-fse-2019-artifact .<br>The source code in the archive are under their respective licenses and are not governed by licence of the remainder of the archive.<br>
DOI: 10.6084/m9.figshare.8427056
title: Data for "Teachers’ choice of content and consideration of controversial and sensitive issues in teaching of secondary school genetics"

description: Raw translated (Finnish to English) data from the interviews.
DOI: 10.6084/m9.figshare.8427056.v1
title: Data for "Teachers’ choice of content and consideration of controversial and sensitive issues in teaching of secondary school genetics"

description: Raw translated (Finnish to English) data from the interviews.
DOI: 10.6084/m9.figshare.8427062.v2
title: Evaluation of vaccine delivery systems for inducing long-lived antibody responses to <i>Dermanyssus gallinae</i> antigen in laying hens

description: <i>Dermanyssus gallinae</i>, the poultry red mite, is a global threat to the commercial egg-laying industry. Control of <i>D. gallinae</i> is difficult, with only a limited number of effective pesticides and non-chemical treatments available. Here, we characterize the candidate vaccine antigen <i>D. gallinae</i> cathepsin D-1 (Dg-CatD-1) and demonstrate that purified refolded recombinant Dg-Cat-D1 (rDg-CatD-1) is an active aspartyl proteinase which digests haemoglobin with a pH optimum of pH 4. Soluble protein extracts from <i>D. gallinae</i> also have haemoglobinase activity, with a pH optimum comparable to the recombinant protein, and both proteinase activities were inhibited by the aspartyl proteinase inhibitor Pepstatin A. Enzyme activity and the ubiquitous localization of Dg-CatD-1 protein in sections of adult female mites is consistent with Dg-CatD-1 being a lysosomal proteinase. Using Dg-CatD-1 as a model vaccine antigen, we compared vaccine delivery methods in laying hens via vaccination with: (i) purified rDg-CatD-1 with Montanide™ ISA 71 VG adjuvant; (ii) recombinant DNA vaccines for expression of rDg-CatD-1 and (iii) transgenic coccidial parasite <i>Eimeria tenella</i> expressing rDg-CatD-1. In two independent trials, only birds vaccinated with rDg-CatD-1 with Montanide™ ISA 71 VG produced a strong and long-lasting serum anti-rDg-Cat-D1 IgY response, which was significantly higher than that in control birds vaccinated with adjuvant only. Furthermore, we showed that egg-laying rates of <i>D. gallinae</i> mites fed on birds vaccinated with rDg-CatD-1 in Montanide™ ISA 71 VG was reduced significantly compared with mites fed on unvaccinated birds. <b>RESEARCH HIGHLIGHTS</b><i>Dermanyssus gallinae</i> cathepsin D-1 (Dg-CatD-1) digests haemoglobinVaccination of hens with rDg-CatD-1 in Montanide™ ISA 71 VG results in long-lasting IgY levelsSerum anti-rDg-CatD-1 antibodies reduce egg laying in <i>D. gallinae</i> after a single blood meal <i>Dermanyssus gallinae</i> cathepsin D-1 (Dg-CatD-1) digests haemoglobin Vaccination of hens with rDg-CatD-1 in Montanide™ ISA 71 VG results in long-lasting IgY levels Serum anti-rDg-CatD-1 antibodies reduce egg laying in <i>D. gallinae</i> after a single blood meal
DOI: 10.6084/m9.figshare.8427044.v1
title: Just Fuzz It: Solving Floating-point Constraints Using Coverage-guided Fuzzing

description: This is the artifact for our FSE 2019 paper titled "Just Fuzz It: Solving Floating-point Constraints Using Coverage-guided Fuzzing".<br>The corresponding git repository for this can be found at https://github.com/mc-imperial/jfs-fse-2019-artifact .<br>The source code in the archive are under their respective licenses and are not governed by licence of the remainder of the archive.<br>
DOI: 10.6084/m9.figshare.8427062.v1
title: Evaluation of vaccine delivery systems for inducing long-lived antibody responses to <i>Dermanyssus gallinae</i> antigen in laying hens

description: <i>Dermanyssus gallinae</i>, the poultry red mite, is a global threat to the commercial egg-laying industry. Control of <i>D. gallinae</i> is difficult, with only a limited number of effective pesticides and non-chemical treatments available. Here, we characterize the candidate vaccine antigen <i>D. gallinae</i> cathepsin D-1 (Dg-CatD-1) and demonstrate that purified refolded recombinant Dg-Cat-D1 (rDg-CatD-1) is an active aspartyl proteinase which digests haemoglobin with a pH optimum of pH 4. Soluble protein extracts from <i>D. gallinae</i> also have haemoglobinase activity, with a pH optimum comparable to the recombinant protein, and both proteinase activities were inhibited by the aspartyl proteinase inhibitor Pepstatin A. Enzyme activity and the ubiquitous localization of Dg-CatD-1 protein in sections of adult female mites is consistent with Dg-CatD-1 being a lysosomal proteinase. Using Dg-CatD-1 as a model vaccine antigen, we compared vaccine delivery methods in laying hens via vaccination with: (i) purified rDg-CatD-1 with Montanide™ ISA 71 VG adjuvant; (ii) recombinant DNA vaccines for expression of rDg-CatD-1 and (iii) transgenic coccidial parasite <i>Eimeria tenella</i> expressing rDg-CatD-1. In two independent trials, only birds vaccinated with rDg-CatD-1 with Montanide™ ISA 71 VG produced a strong and long-lasting serum anti-rDg-Cat-D1 IgY response, which was significantly higher than that in control birds vaccinated with adjuvant only. Furthermore, we showed that egg-laying rates of <i>D. gallinae</i> mites fed on birds vaccinated with rDg-CatD-1 in Montanide™ ISA 71 VG was reduced significantly compared with mites fed on unvaccinated birds. <b>RESEARCH HIGHLIGHTS</b><i>Dermanyssus gallinae</i> cathepsin D-1 (Dg-CatD-1) digests haemoglobinVaccination of hens with rDg-CatD-1 in Montanide™ ISA 71 VG results in long-lasting IgY levelsSerum anti-rDg-CatD-1 antibodies reduce egg laying in <i>D. gallinae</i> after a single blood meal <i>Dermanyssus gallinae</i> cathepsin D-1 (Dg-CatD-1) digests haemoglobin Vaccination of hens with rDg-CatD-1 in Montanide™ ISA 71 VG results in long-lasting IgY levels Serum anti-rDg-CatD-1 antibodies reduce egg laying in <i>D. gallinae</i> after a single blood meal
DOI: 10.6084/m9.figshare.8426993
title: Supplementary Table1.docx

description: Supplementary Table 1 of the article <b>Diagnostic Roles of Urinary Kidney Injury Molecule 1 and Soluble C5b-9 in Acute Tubulointerstitial Nephritis</b>
DOI: 10.6084/m9.figshare.8427044.v3
title: Just Fuzz It: Solving Floating-point Constraints Using Coverage-guided Fuzzing

description: This is the artifact for our FSE 2019 paper titled "Just Fuzz It: Solving Floating-point Constraints Using Coverage-guided Fuzzing".<br>The corresponding git repository for this can be found at https://github.com/mc-imperial/jfs-fse-2019-artifact .<br>The source code in the archive are under their respective licenses and are not governed by licence of the remainder of the archive.<br>
DOI: 10.6084/m9.figshare.8426996
title: Supplementary Material for: Determinants of Functional Independence or Its Loss following Subthalamic Nucleus Stimulation in Parkinson’s Disease

description: <b><i>Objective:</i></b> This study aimed to describe the change in functional status following bilateral subthalamic nucleus stimulation (STN-DBS) in Parkinson’s disease (PD) and to identify predictors of postoperative functional dependence. <b><i>Methods:</i></b> We included PD patients with bilateral STN-DBS who had complete Schwab & England Activities of Daily Living (S&E ADL) Scale data at baseline and 6 months after surgery from our prospective registry. Functional dependence was defined as an S&E ADL score of less than 80%. All data were collected from the <i>on</i>-medication state and <i>on</i>-stimulation state (after surgery). Logistic regression analyses were performed to determine the factors predictive of functional dependence after surgery. <b><i>Results:</i></b> A total of 196 patients were included. At baseline, 41 patients were functionally dependent and the other 155 were functionally independent. Among the patients with preoperative dependence, 32 (78%) became functionally independent after surgery, and this conversion was associated with a lower baseline axial score (<i>p</i> = 0.012). Among the patients with preoperative independence, 21 (14%) developed postoperative dependence, and this conversion was associated with a higher baseline axial score (<i>p</i> = 0.013) and its smaller improvement (<i>p</i> &lt; 0.001). Female sex (odds ratio [OR] 3.214; 95% confidence interval [CI] 1.210–8.542; <i>p</i> = 0.019) and a higher baseline axial score (OR 1.184; 95% CI 1.056–1.327; <i>p</i> = 0.004) significantly predicted the risk of postoperative functional dependence. <b><i>Conclusions:</i></b> We found that functional status following bilateral STN-DBS is closely related to preoperative axial symptoms. When loss of independence is a potential target for STN-DBS, clinicians should take into consideration the severity of axial impairment before surgery.
DOI: 10.6084/m9.figshare.8427044.v2
title: Just Fuzz It: Solving Floating-point Constraints Using Coverage-guided Fuzzing

description: This is the artifact for our FSE 2019 paper titled "Just Fuzz It: Solving Floating-point Constraints Using Coverage-guided Fuzzing".<br>The corresponding git repository for this can be found at https://github.com/mc-imperial/jfs-fse-2019-artifact .<br>The source code in the archive are under their respective licenses and are not governed by licence of the remainder of the archive.<br>
DOI: 10.6084/m9.figshare.8426993.v1
title: Supplementary Table1.docx

description: Supplementary Table 1 of the article <b>Diagnostic Roles of Urinary Kidney Injury Molecule 1 and Soluble C5b-9 in Acute Tubulointerstitial Nephritis</b>
DOI: 10.6084/m9.figshare.8426996.v1
title: Supplementary Material for: Determinants of Functional Independence or Its Loss following Subthalamic Nucleus Stimulation in Parkinson’s Disease

description: <b><i>Objective:</i></b> This study aimed to describe the change in functional status following bilateral subthalamic nucleus stimulation (STN-DBS) in Parkinson’s disease (PD) and to identify predictors of postoperative functional dependence. <b><i>Methods:</i></b> We included PD patients with bilateral STN-DBS who had complete Schwab & England Activities of Daily Living (S&E ADL) Scale data at baseline and 6 months after surgery from our prospective registry. Functional dependence was defined as an S&E ADL score of less than 80%. All data were collected from the <i>on</i>-medication state and <i>on</i>-stimulation state (after surgery). Logistic regression analyses were performed to determine the factors predictive of functional dependence after surgery. <b><i>Results:</i></b> A total of 196 patients were included. At baseline, 41 patients were functionally dependent and the other 155 were functionally independent. Among the patients with preoperative dependence, 32 (78%) became functionally independent after surgery, and this conversion was associated with a lower baseline axial score (<i>p</i> = 0.012). Among the patients with preoperative independence, 21 (14%) developed postoperative dependence, and this conversion was associated with a higher baseline axial score (<i>p</i> = 0.013) and its smaller improvement (<i>p</i> &lt; 0.001). Female sex (odds ratio [OR] 3.214; 95% confidence interval [CI] 1.210–8.542; <i>p</i> = 0.019) and a higher baseline axial score (OR 1.184; 95% CI 1.056–1.327; <i>p</i> = 0.004) significantly predicted the risk of postoperative functional dependence. <b><i>Conclusions:</i></b> We found that functional status following bilateral STN-DBS is closely related to preoperative axial symptoms. When loss of independence is a potential target for STN-DBS, clinicians should take into consideration the severity of axial impairment before surgery.
DOI: 10.6084/m9.figshare.8426984
title: Impact of recreational scuba diving on coral reefs in Seychelles

description: This datset was obtained from 205 recreational scuba divers who dived around the island of Praslin, Seychelles. Data on diver demographics, environmental variables and dive characteristics were collected and collated in order to assess what variables were mostly influencing diver contact rates on coral reefs at dive sites. <br>Information for diver demographics were taken from the forms required by the dive operator to dive with them. Environmental variables (depth and temperature) were taken with a Scubapro Chromis dive computer. <br><br>Diver contacts were recorded for the first 20 minutes of a scuba diver after a 1 minute adjustment period. Up to four divers in a group were surveyed per dive and divers were only surveyed once. The surveyor was responsible for all the data collection and stayed approximately 3-5 metres behind or to the side of the dive group and posed as a client to avoid arousing suspicion, thus influecing behavioural changes.<br>The type of physical contact made by divers were first classified into categories (grabbing hold, pushing offs, leg touches, knee etc) and were then split into intentional and unintentional contacts. Each contact was then classified by the severity of the impact i.e. break, fragment, abrasion etc. Also noted was the marine organism that was contacted at that time. Contacts from the contact type were totalled. Variables from the diver demographics, environmental factors and dive characteristics were analysed against the total contacts made by individual divers. <br>This research was commissioned by the Seychelles National Park Authority and abided by the ethical requirements of undertaking this study. <br><br>
DOI: 10.6084/m9.figshare.8426963
title: Supplementary Material for: Validation of the German Version of the Power of Food Scale in a General Population Sample

description: <b><i>Objective:</i></b> The Power of Food Scale (PFS) is a self-report instrument for assessing appetitive motivation in the absence of caloric needs. The study aim was to validate the German PFS version in a large population sample. <b><i>Methods:</i></b> Complete information on all PFS items was available from 2,421 respondents (age ≥14) of a nationally representative sample of the German population. We examined the psychometric properties of the German PFS version and provided population-based normative data. <b><i>Results:</i></b> The 3-factor structure of the original scale was replicated in confirmatory factor analysis. The German PFS version demonstrated good internal consistency (α = 0.92 for the total scale). It was well accepted by the respondents, as indicated by a low proportion of missing item values (≤0.56%). While no significant differences were observed in the PFS mean scores between men and women, the scores increased across BMI categories. PFS was positively correlated with a measure of global eating disorder psychopathology (Eating Disorder Examination-Questionnaire 8) and the ultra-brief Patient Health Questionnaire for depression and anxiety. <b><i>Conclusions:</i></b> Our findings suggest that the German PFS version has adequate psychometric properties and good reliability for measuring hedonic hunger in the general population. The provided population-based norms can be used for individual assessment.
DOI: 10.6084/m9.figshare.8426942
title: ss_survival_nibmg

description: <br>This is a zipped (compressed) data set file containing two <b>R </b>data packages: <b>"ssnibmgsurv"</b>, <b>"nibmgsurvmeta". </b>The data package <b>"ssnibmgsurv" </b>contains gene expression data of Indian sepsis patients. The data package <b>"</b><b>nibmgsurvmeta</b><b>" </b>contains gene expression data of 8 sepsis datasets published in GEO (gene expression omnibus) repository.
DOI: 10.6084/m9.figshare.8426936
title: Tarball from Minimal <i>n</i>-noids in hyperbolic and anti-de Sitter 3-space

description: Tarball contains computer data pertaining to the manuscript, along with a documentation text.
DOI: 10.6084/m9.figshare.8426936.v1
title: Tarball from Minimal <i>n</i>-noids in hyperbolic and anti-de Sitter 3-space

description: Tarball contains computer data pertaining to the manuscript, along with a documentation text.
DOI: 10.6084/m9.figshare.8426942.v2
title: ss_survival_nibmg

description: <br>This is a zipped (compressed) data set file containing two <b>R </b>data packages: <b>"ssnibmgsurv"</b>, <b>"nibmgsurvmeta". </b>The data package <b>"ssnibmgsurv" </b>contains gene expression data of Indian sepsis patients. The data package <b>"</b><b>nibmgsurvmeta</b><b>" </b>contains gene expression data of 8 sepsis datasets published in GEO (gene expression omnibus) repository.
DOI: 10.6084/m9.figshare.8426942.v1
title: ss_survival_nibmg

description: <br>This is a zipped (compressed) data set file containing two <b>R </b>data packages: <b>"ssnibmgsurv"</b>, <b>"nibmgsurvmeta". </b>The data package <b>"ssnibmgsurv" </b>contains gene expression data of Indian sepsis patients. The data package <b>"</b><b>nibmgsurvmeta</b><b>" </b>contains gene expression data of 8 sepsis datasets published in GEO (gene expression omnibus) repository.