cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.17632/prmjp3mx58
title: Rewiring macrophage-neuro immunometabolic crosstalk mitigates sepsis-induced lung injury and neurologic damage

description: Sepsis remains a leading cause of mortality in intensive care units, with its associated organ dysfunction primarily driven by uncontrolled inflammation and neuroimmune dysregulation. Among affected organs, the lung is particularly vulnerable, with injury involving both immune-mediated tissue damage and inflammation-induced neuronal impairment. Yet, whether coordinated targeting of immune and neural compartments can achieve synergistic and durable therapeutic benefits remains unknown. Here, we report a rationally engineered, dual-functional, enzyme-responsive nanoplatform (SJNPs) that co-delivers the glutamate production inhibitor JHU083 and the neuroprotective spermine (Spm) to reprogram macrophage-neuron immunometabolic interactions. SJNPs suppressed pro-inflammatory, M1-associated macrophage activation while promoting M2 polarization, which in turn drove robust secretion of the neurotrophic factor nerve growth factor (NGF) and preserved pulmonary neuronal integrity. Mechanistically, inhibition of glutamate metabolism reprogrammed macrophage polarization and activated NGF-mediated neurotrophic signaling, establishing NGF as a key mediator linking immune modulation to neural protection. In murine sepsis models, SJNPs attenuated systemic cytokine storms, mitigated alveolar damage, alleviated neurological injury, and improved survival. This study identifies macrophage-neuron immunometabolic crosstalk as a previously underexplored therapeutic target for septic lung injury characterized by neuronal damage, and establishes metabolic reprogramming of macrophages as a promising strategy for integrated immunomodulatory and neuroprotective therapy in sepsis.
DOI: 10.17632/prmjp3mx58.1
title: Rewiring macrophage-neuro immunometabolic crosstalk mitigates sepsis-induced lung injury and neurologic damage

description: Sepsis remains a leading cause of mortality in intensive care units, with its associated organ dysfunction primarily driven by uncontrolled inflammation and neuroimmune dysregulation. Among affected organs, the lung is particularly vulnerable, with injury involving both immune-mediated tissue damage and inflammation-induced neuronal impairment. Yet, whether coordinated targeting of immune and neural compartments can achieve synergistic and durable therapeutic benefits remains unknown. Here, we report a rationally engineered, dual-functional, enzyme-responsive nanoplatform (SJNPs) that co-delivers the glutamate production inhibitor JHU083 and the neuroprotective spermine (Spm) to reprogram macrophage-neuron immunometabolic interactions. SJNPs suppressed pro-inflammatory, M1-associated macrophage activation while promoting M2 polarization, which in turn drove robust secretion of the neurotrophic factor nerve growth factor (NGF) and preserved pulmonary neuronal integrity. Mechanistically, inhibition of glutamate metabolism reprogrammed macrophage polarization and activated NGF-mediated neurotrophic signaling, establishing NGF as a key mediator linking immune modulation to neural protection. In murine sepsis models, SJNPs attenuated systemic cytokine storms, mitigated alveolar damage, alleviated neurological injury, and improved survival. This study identifies macrophage-neuron immunometabolic crosstalk as a previously underexplored therapeutic target for septic lung injury characterized by neuronal damage, and establishes metabolic reprogramming of macrophages as a promising strategy for integrated immunomodulatory and neuroprotective therapy in sepsis.
DOI: 10.17632/f2yn5jjk43
title: Increased soil salinization slows biochar aging and limits microbial colonization

description: This repository contains the data used in the study “Increased soil salinization slows biochar aging and limits microbial colonization”, including raw sequencing data and key physicochemical datasets. The research investigates the mechanisms by which soil salinization influences biochar aging and microbial colonization characteristics.
DOI: 10.17632/f2yn5jjk43.1
title: Increased soil salinization slows biochar aging and limits microbial colonization

description: This repository contains the data used in the study “Increased soil salinization slows biochar aging and limits microbial colonization”, including raw sequencing data and key physicochemical datasets. The research investigates the mechanisms by which soil salinization influences biochar aging and microbial colonization characteristics.
DOI: 10.17632/5njg46dfj4.1
title: Data-Driven Chemical Domain for Polypharmacology Agents: Focus on Alzheimer’s Disease

description: Exploratory data domains for Alzheimer's Disease (AD) analysis are inherently complex due to the disease's polyetiological and polypathogenic nature. Addressing this complexity requires a multidisciplinary approach to data exploration. Effective drug discovery and repositioning strategies must account for the diversity of ligand–receptor interactions, aiming to expand the scope of the exploratory domain and identify therapeutic solutions targeting the most prevalent pathological features of AD. Considering the multifactorial characteristics of the disease, we propose a data retrieval and extraction strategy that integrates heterogeneous and relevant information from multiple bioinformatic databases, focusing on the key targets Acetylcholinesterase (AChE), Butyrylcholinesterase (BChE), and Beta-secretase 1 (BACE1). This strategy generates datasets that capture diverse facets of the disease's complexity, enabling comprehensive domain representations. To address the inherent challenges in the investigative process, we leveraged ChEMBL, ZINC, and the Protein Data Bank (PDB), producing an extensive and well-curated dataset that facilitates the analysis of causal relationships and reduces the complexity of AD-related research.
DOI: 10.17632/bzt2y9s7ys.1
title: Integrative Omics, Functional Characterization and Androgen Receptor Regulation Reveal the Dual Roles of SEMA5B in Prostate Cancer

description: This research aimed to study the role of Semaphorin 5B (SEMA5B) in prostate cancer, focusing on its functional characterization, regulation by androgen receptor, and impact on the tumor immune microenvironment. In vitro and in vivo experiments were performed using prostate cancer cell lines and the LNCaP cell line overexpressing SEMA5B was examined using transcriptome sequencing. Immune cell infiltration and metabolic pathways were assessed using bioinformatics tools and functional assays. Despite its association with elevated expression levels in prostate cancer and poorer patient outcomes, SEMA5B demonstrated tumor-suppressive properties in vitro, suppressing cellular proliferation and migration. The androgen receptor was found to transcriptionally upregulate SEMA5B expression. Paradoxically, SEMA5B promoted an immunosuppressive microenvironment by enhancing Tregs and M2 macrophages, potentially explaining its oncogenic association. Metabolic pathway analysis linked SEMA5B to oxidative phosphorylation downregulation. This study uncovers the dual roles of SEMA5B in prostate cancer, highlighting its context-dependent functions as both a tumor suppressor and microenvironment modulator. The AR-SEMA5B axis offers novel therapeutic insights for castration-resistant prostate cancer, emphasizing the need to target immune-metabolic crosstalk in treatment strategies.
DOI: 10.17632/7sswmyct6p
title: Sediment records in Hulun Lake
DOI: 10.17632/7sswmyct6p.1
title: Sediment records in Hulun Lake
DOI: 10.17632/4vbmfj4ksf.2
title: EM Replicate

description: This is a copy of the program and data from the paper Supply chain digitalization and corporate innovation: Evidence from China.
DOI: 10.17632/rbns3nvyhn
title: Dilemas Éticos nas Guerras do Futuro - Supplementary material

description: Planilhas de Excel contendo os dados coletados dos Especialistas e os resultados do AHP.
DOI: 10.17632/rbns3nvyhn.1
title: Dilemas Éticos nas Guerras do Futuro - Supplementary material

description: Planilhas de Excel contendo os dados coletados dos Especialistas e os resultados do AHP.
DOI: 10.17632/ywjm6x2665
title: Digital technology and regional income inequality: are better institutions the solution

description: The do file (ABRP_dofile) and the related dataset (ABRP_db) describe how to obtain the tables of our paper "Digital technology and regional income inequality: are better institutions the solution".
The aim of the paper was to examine the effect of regional digital technology (including computing, communication equipment, software, and databases) on income distribution at the regional level. We aim to fill a gap in existing research by exploring the moderating role of formal and informal institutions —such as bonding and bridging social capital— in shaping how digital technology affects income inequality across European NUTS2 regions from 2006 to 2016. The results indicate that regions with greater access to digital technology are prone to higher levels of income inequality. However, this negative link is mitigated by strong formal and informal institutions, particularly through improved government effectiveness and bridging social capital. The findings are robust to potential endogeneity concerns, as demonstrated by the instrumental variable approach adopted.
DOI: 10.17632/ywjm6x2665.2
title: Digital technology and regional income inequality: are better institutions the solution

description: The do file (ABRP_dofile) and the related dataset (ABRP_db) describe how to obtain the tables of our paper "Digital technology and regional income inequality: are better institutions the solution".
The aim of the paper was to examine the effect of regional digital technology (including computing, communication equipment, software, and databases) on income distribution at the regional level. We aim to fill a gap in existing research by exploring the moderating role of formal and informal institutions —such as bonding and bridging social capital— in shaping how digital technology affects income inequality across European NUTS2 regions from 2006 to 2016. The results indicate that regions with greater access to digital technology are prone to higher levels of income inequality. However, this negative link is mitigated by strong formal and informal institutions, particularly through improved government effectiveness and bridging social capital. The findings are robust to potential endogeneity concerns, as demonstrated by the instrumental variable approach adopted.
DOI: 10.17632/phyx35hcy6
title: Multilayered Hygroscopic Actuation in Pine Cone Scales

description: This repository provides the dataset accompanying the publication “Beyond the Bilayer: Multilayered Hygroscopic Actuation in Pine Cone Scales” in the Beilstein Journal of Nanotechnology by Kim Ulrich, Max David Mylo, Tom Masselter, Fabian Scheckenbach, Sophia Fischerbauer, Martin Nopens, Silja Flenner, Imke Greving, Linnea Hesse, and Thomas Speck.

Additional raw data obtained, e.g., obtained from synchrotron radiation-based nano-tomography, are excluded due to data size, but can be made available upon reasonable request.
DOI: 10.17632/phyx35hcy6.1
title: Multilayered Hygroscopic Actuation in Pine Cone Scales

description: This repository provides the dataset accompanying the publication “Beyond the Bilayer: Multilayered Hygroscopic Actuation in Pine Cone Scales” in the Beilstein Journal of Nanotechnology by Kim Ulrich, Max David Mylo, Tom Masselter, Fabian Scheckenbach, Sophia Fischerbauer, Martin Nopens, Silja Flenner, Imke Greving, Linnea Hesse, and Thomas Speck.

Additional raw data obtained, e.g., obtained from synchrotron radiation-based nano-tomography, are excluded due to data size, but can be made available upon reasonable request.
DOI: 10.15468/dl.mwq5nk
title: Occurrence Download

description: A dataset containing 44603521 species occurrences available in GBIF matching the query:
{
 "and" : [
 {
 "and" : [
 "HasGeospatialIssue is false",
 "HasCoordinate is true",
 "OccurrenceStatus is Present",
 {
 "not" : {
 "BasisOfRecord" : [
 "is one of (Fossil, Living Specimen)"
 ]
 }
 }
 ]
 },
 "TaxonKey is one of (Asteraceae)"
 ]
}

 The dataset includes 44603521 records from 8893 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0009803-250920141307145/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.5281/zenodo.5648918
title: CIFAR-10G

description: Initial release of the CIFAR-10G dataset.
DOI: 10.5281/zenodo.3517209
title: Data for the publication "Meta-analysis of fecal metagenomes reveals global microbial signatures that are specific for colorectal cancer"

description: This dataset encompasses all data needed to reproduce the analyses presented in Meta-analysis of fecal metagenomes reveals global microbial signatures that are specific for colorectal cancer You can also check the GitHub repository
DOI: 10.5281/zenodo.4596571
title: Accompanying data - "The quandary of DNA-based treatment assessment in de novo metastatic prostate cancer in the era of precision oncology"

description: Molecular data of case report described in the manuscript "The quandary of DNA-based treatment assessment in de novo metastatic prostate cancer in the era of precision oncology".
DOI: 10.5281/zenodo.4409306
title: Labeled banana bunch dataset

description: Dataset of multiple labeled images for training a neural network.
DOI: 10.5281/zenodo.4019112
title: CAS FGOALS-f3-L model output

description: The file includes the model output of the CAS FGOALS-f3-L which associated with the assessing of the aerosol effective radiative forcing.
DOI: 10.5281/zenodo.4305410
title: Data for manuscript "The synergistic role of sulfuric acid, bases, and oxidized organics governing new-particle formation in Beijing"

description: Data for the manuscript "The synergistic role of sulfuric acid, bases, and oxidized organics governing new-particle formation in Beijing" submitted to Geophysical Research Letters
DOI: 10.5281/zenodo.6426197
title: An evaluation of new particle formation events in Helsinki during a Baltic Sea cyanobacterial summer bloom

description: The data set is linked to the manuscript: Thakur, R. C., Dada, L., Beck, L. J., Quéléver, L. L. J., Chan, T., Marbouti, M., He, X.-C., Xavier, C., Sulo, J., Lampilahti, J., Lampimäki, M., Tham, Y. J., Sarnela, N., Lehtipalo, K., Norkko, A., Kulmala, M., Sipilä, M., and Jokinen, T.: An evaluation of new particle formation events in Helsinki during a Baltic Sea cyanobacterial summer bloom, Atmos. Chem. Phys. Discuss. 2022.
DOI: 10.5281/zenodo.820592
title: Landslides From Space - Chitan Landslide, China (7Th May 2016)

description: Workers employed for a hydropower project in Fujian province had their dormitories close to the river. On 7th May 2016, a landslide was triggered through heavy rainfall. More than 40 construction workers died in this event.

The pre-event acquisition is from 7th February 2016 (Sentinel-2) and the post-event acquisition is from 26th July 2016 (Sentinel-2). A false colour composite with near-infrared, red and green band is visualised as RGB image.<br>
<br>
<em>Contains modified Copernicus Sentinel data (2016)</em>
description: {"references": ["http://blogs.agu.org/landslideblog/2016/05/10/chitan-hydropower-landslide/"]}
DOI: 10.3886/e208322
title: Code and Data for "Constant Discounting, Temporal Instability and Dynamic Inconsistency in Denmark: A Longitudinal Field Experiment"

description: Replication code and data for "Constant Discounting, Temporal Instability and Dynamic Inconsistency in Denmark: A Longitudinal Field Experiment" (Glenn W. Harrison; Morten I. Lau; and Hong Il Yoo), forthcoming in the International Economic Review. See -HarrisonLauYoo_2024_IER_README.pdf-<b> </b>in the 7z folder for further information.
DOI: 10.3886/e208322v1
title: Code and Data for "Constant Discounting, Temporal Instability and Dynamic Inconsistency in Denmark: A Longitudinal Field Experiment"

description: Replication code and data for "Constant Discounting, Temporal Instability and Dynamic Inconsistency in Denmark: A Longitudinal Field Experiment" (Glenn W. Harrison; Morten I. Lau; and Hong Il Yoo), forthcoming in the International Economic Review. See -HarrisonLauYoo_2024_IER_README.pdf-<b> </b>in the 7z folder for further information.
DOI: 10.5281/zenodo.4611494
title: Dataset of manuscript "Automatic fault mapping in remote optical images and topographic data with deep learning", Journal of Geophysical Research - Solid Earth, 2021

description: The dataset includes:<br> - the image and topographic data used in the study<br> - the ground truth used in the study<br> - the parameters of the model MRef developed in the study<br> - the Supplementary documents and figures discussed in the paper
description: Contact : Laboratoire Géoazur 250 rue Albert Einstein - 06560 Valbonne +33 4 83 61 86 35 Emails : matteo@geoazur.unice.fr, lionelmatteo93@gmail.com manighetti@geoazur.unice.fr
DOI: 10.15468/dl.agndfq
title: Occurrence Download

description: A dataset containing 1380766 species occurrences available in GBIF matching the query:
{
 "and" : [
 {
 "and" : [
 "Country is one of (New Zealand)",
 {
 "not" : {
 "Issue" : [
 "is Country coordinate mismatch"
 ]
 }
 }
 ]
 },
 {
 "and" : [
 "Geometry POLYGON((172.07529165789686 -35.75210613325339,172.07529165789686 -36.8723036766541,176.47177967328957 -36.8723036766541,176.47177967328957 -35.75210613325339,172.07529165789686 -35.75210613325339))",
 "HasCoordinate is one of (true)",
 "HasGeospatialIssue is one of (false)"
 ]
 }
 ]
}

 The dataset includes 1380766 records from 384 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0048199-240626123714530/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.5281/zenodo.4771487
title: SiEUGreen - Dataset Landuse

description: The purpose of this collection of data is to give an overview of existing experiences across Europe on the organization and flow of people, land, resources and knowledge on UA in different institutional, natural and technical settings. This datasets provides a useful starting point for further analyses on what are the key areas for in-depth research for developing urban agriculture providing positive impacts for the environment and for local communities.
DOI: 10.5281/zenodo.6299076
title: DeepCAD-RT dataset: mouse neurites

description: DeepCAD-RT dataset: mouse neurites
DOI: 10.15468/dl.pnrbmh
title: Occurrence Download

description: A dataset containing 44 species occurrences available in GBIF matching the query:
{
 "Geometry" : [
 "POLYGON ((149.160023 -32.450082, 149.160023 -32.454573, 149.155531 -32.454573, 149.155531 -32.456819, 149.160023 -32.456819, 149.160023 -32.459065, 149.162269 -32.459065, 149.162269 -32.454573, 149.164515 -32.454573, 149.164515 -32.452327, 149.162269 -32.452327, 149.162269 -32.450082, 149.160023 -32.450082))"
 ]
}

 The dataset includes 44 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0048220-240626123714530/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.5281/zenodo.4656075
title: Kaggle Wikipedia Web Traffic Daily Dataset (without Missing Values)

description: This dataset was used in the Kaggle Wikipedia Web Traffic forecasting competition. It contains 145063 daily time series representing the number of hits or web traffic for a set of Wikipedia pages from 2015-07-01 to 2017-09-10. The original dataset contains missing values. They have been simply replaced by zeros.
description: {"references": ["Google, 2017. Web traffic time series forecasting. URL https://www.kaggle.com/c/web-traffic-time-series-forecasting"]}
DOI: 10.5281/zenodo.5511666
title: ChinaCroplandSM1km: 1km-gridded daily Soil Moisture for Crop drylands across China

description: ChinaCroplandSM1km provides 1km-gridded daily Soil Moisture for Crop drylands across China over 1993–2010, which contains four daily datasets separately by crop type and soil depth (crop-type <sub>soil-depth</sub>). This dataset is wheat<sub>0-10.</sub> *** The data file is in “.tif" format *** Spatial extent: wheat drylands across China *** Soil depth: 0-10cm *** Temporal Resolution: Daily *** Pixel size: 1000 m *** Projection information: GCS_WGS_1984 *** Filename convention: Year_DOY.tif *** Year: Values from 1993 to 2010
DOI: 10.5281/zenodo.1002302
title: In00100 Gwalior Inscription Of Mihirakula

description: Fleet, John F., <em>Inscriptions of the Early Guptas </em>(Corpus Inscriptionum Indicarum, vol. 3) (Calcutta: Government of India, Central Publications Branch, 1888): 163-164.
description: http://siddham.uk/inscription/IN00100
DOI: 10.5281/zenodo.1160410
title: Newcastle Polysomnography And Accelerometer Data

description: # Newcastle PSG+Accelerometer study 2015

This data set contains 55 .bin files, 28 .txt files, and one .csv file,<br>
which were collected in Newcastle upon Tyne (UK) to evaluate an <br>
accelerometer-based algorithm for sleep classification.<br>
The data come form a a single night polysomnography recording in <br>
28 sleep clinic patients. A description of the experimental <br>
protocol can be found in this open access PLoSONE paper from 2015: <br>
https://doi.org/10.1371/journal.pone.0142533.

 

## Polysomnography

Sleep scores derived from polysomnography are stored in the .txt files. <br>
Each file represents a time series (one night) of one participant.<br>
The resolution of the scoring is <br>
30 seconds. Participants are numbered. The participant number is <br>
included in the file names as “mecsleep01_...”. pariticpants_info.csv is a<br>
dictionary of participant number, diagnosis, age, and sex.

## Accelerometer data

Accelerometer data from brand GENEActiv (https://www.activinsights.com) are <br>
stored in .bin files. Per participant two accelerometers were used: <br>
One accelerometer on each wrist (left and right). The right wrist from <br>
participant 10 is missing, hence the total number of 55 bin files. <br>
The tri-axial (three axis) accelerometers were configured to record <br>
at 85.7 Hertz. The accelerometer data can be read with R package <br>
GENEAread https://cran.r-project.org/web/packages/GENEAread/index.html. <br>
Additional information on the accelerometer can be found on the <br>
manufacturers product website: <br>
https://www.activinsights.com/resources-support/geneactiv/downloads-software/, <br>
including a description of the binary file structure on page 27 of <br>
this (pdf) file: https://49wvycy00mv416l561vrj345-wpengine.netdna-ssl.com/wp-content/uploads/2014/03/geneactiv_instruction_manual_v1.2.pdf.<br>
The participant number and the body side on which the accelerometer <br>
is worn are included in the file names as “MECSLEEP01_left wrist...”.

## Participant information

The .csv file as included in this dataset contains a dictionary <br>
of the participant numbers, sleep disorder diagnosis, <br>
participant age at the time of measurement, and sex.

## Example processing

The code we used ourselves to process this data can be found in this <br>
GitHub repository: https://github.com/wadpac/psg-ncl-acc-spt-detection-eval.<br>
Note that we use R package GGIR: https://cran.r-project.org/web/packages/GGIR/, <br>
which calls R package GENEAread for reading the binary data.
description: ## Questions and citation

For questions about this data set please contact v.vanhees@esciencecenter.nl. 
Please cite this dataset with the doi as provided on the zenodo page where 
you downloaded this dataset.