cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.21923301.v1
title: Supplementary Material for: Intralesional corticosteroid administration in the treatment of keloids: a scoping review on injection methods

description: Background Intralesional corticosteroid administration (ICA) is a first-line treatment for keloids. However, its clinical results are still highly variable and often suboptimal. Treatment results may strongly be influenced by various operator dependent factors. The aim of this study is to map the details of ICA in keloids described in randomized controlled trials (RCTs), hence presenting the scientific practice of a first-line treatment for keloids in the best available evidence. Summary A systematic search was performed on PubMed, Ovid MEDLINE, Ovid EMBASE and CENTRAL. Eligible studies were RCTs including patients with keloids treated with intralesional corticosteroids. Treatment and study design related data were charted on a predefined form. Thirty-eight RCTs were included for data extraction. Triamcinolone acetonide was used in 37 (97.4%) studies. Dosing per cm2 could only be compared among ten (26%) studies, and varied from 1 to 20 mg. The maximum dose per session varied from 20 to 80 mg. Anesthetics were administered locally and orally in seven and one RCT(s). Treatment intervals varied from weekly to monthly, with four weeks most frequently (50%) used. Needle size was reported in eleven (29%) studies and varied from 26 to 30-gauge. Syringe size was specified in four (11%) studies, being 1 mL. The injection level was described in eleven (29%) studies. Blanching as endpoint was reported in ten (26%) studies. Outcome measures varied widely, from height, surface area or volume, to Vancouver Scar Scale, Patient and Observer Scar Assessment Scale, pain and itch scores, patient satisfaction and different efficacy rates. Only six studies had a follow-up of ≥6 months. Recurrence was identified in two studies with 18 weeks and 1 year of follow-up. Adverse events were reported in 25 (66%) studies. Key messages There is incomplete reporting and substantial heterogeneity in many aspects of ICA and study design among RCTs. This scoping review underscores the urgent need for standardization of treatment protocol and study design to enhance and uniform research conduct among keloid studies.
DOI: 10.6084/m9.figshare.21923682
title: Supplementary Material for: Common benign melanocytic and non-melanocytic skin tumors among the elderly. Results of the Graz Study on Health & Aging (GSHA)

description: Background and objectives: Benign skin tumors are the most common skin findings and contribute to the major reasons for consulting a dermatologist. However, the frequency of benign skin tumors concerning different body areas and their relationship with sun-related behavior have not been sufficiently characterized. We aimed to improve knowledge about the anatomic distribution of the most frequently occurring benign skin tumors among a healthy predominant elderly population. Furthermore, we investigated associations with sun-related habits. Methods: In total, 100 participants, 37 men, and 63 women (mean age: 67.2 years; range: 46-86 years) were enrolled in the Graz Study on Health & Aging (GSHA) cohort. Full body images were investigated for melanocytic nevi, seborrheic keratoses, hemangiomas, dermatofibromas, and lentigines. Information on the phenotypic trait, sun exposure, use of sun-protective measures, and history of sunburns was collected in a questionnaire. Results: Common melanocytic nevi were the most frequently encountered skin lesions. Male sex was associated with multiple common nevi on the abdomen and the presence of atypical nevi. High sun exposure in central European latitudes during adolescence was positively associated with multiple common nevi on the total body. Multiple common nevi and atypical nevi on the back correlated with frequent use of sunscreens with SPF during young adulthood and adolescence, respectively. Conclusion: Our study adds new knowledge about the most frequently occurring benign skin tumors, considering all visible body areas. This research may serve as a reference basis for following epidemiological studies.
DOI: 10.5066/p90mn7h5
title: West Lake Boudreaux Shoreline Protection and Marsh Creation (TE-46): 2021 land-water classification

description: The Louisiana State Legislature created the Coastal Wetlands Planning, Protection and Restoration Act (CWPPRA) in order to conserve, restore, create and enhance Louisiana's coastal wetlands. The wetland restoration plans developed pursuant to these acts specifically require an evaluation of the effectiveness of each coastal wetlands restoration project in achieving long-term solutions to arresting coastal wetlands loss. This data set includes mosaicked aerial photographs for the West Lake Boudreaux Shoreline Protection and Marsh Creation (TE-46) project for 2021. This data is used as a basemap land-water classification. It also serves as a visual tool for project managers to help them identify any obvious problems or land loss within their project boundary. To better evaluate the effectiveness of restoration efforts, a land-water classification is performed on specific CWPPRA sites to help assess landscape changes.
DOI: 10.35078/xi7ghl
title: Replication Data for: Ficha epidemiológica de localidade: Distrito: Uberaba| Município: Araguari

description: Levantamento Triatomínico com operações de campo ocorridas em Minas Gerais pela Superintendência de Campanhas de Saúde Pública (SUCAM) e FUNASA (Fundação Nacional de Saúde), no período de 1979 a 1999, objetivando a busca da presença de vetores da doença de Chagas ou de vestígios dessa presença. A partir dela são orientadas as operações com inseticida (pt) Triatomine survey with field operations carried out in Minas Gerais by the Public Health Campaigns Superintendence (SUCAM) and FUNASA (National Health Foundation), from 1979 to 1999, aiming to search for the presence of Chagas disease vectors or traces of that presence. From it, operations with insecticide are guided (en) Encuesta de triatominos con operaciones de campo realizada en Minas Gerais por la Superintendencia de Campañas de Salud Pública (SUCAM) y FUNASA (Fundación Nacional de Salud), de 1979 a 1999, con el objetivo de buscar la presencia de vectores de la enfermedad de Chagas o rastros de esa presencia. Desde ella se orientan las operaciones con insecticida (es)
DOI: 10.5281/zenodo.7737614
title: The role of teriflunomide in Multiple Sclerosis patient: an observational study

description: Teriflunomide is a drug with immunosuppressive and selective immunomodulatory action, characterized by anti-inflammatory and antiproliferative properties. Several clinical studies have demonstrated the efficacy and safety of this drug in Multiple Sclerosis, estimating a significant improvement in cognitive performance.The aim of our study is to evaluate the effects of teriflunomide by analysing the correlation between brain atrophy and the general cognitive profile and evaluating long-term changes. The effect of teriflunomide was studied in 30 patients with multiple sclerosis and 30 control subjects. Patients underwent a full cognitive profile assessment using the Brief Repeatable Battery of Neuropsychological Tests and a neuroimaging examination with a 3.0 T working scanner.Our results suggested that treatment with teriflunomide could potentially not only slow down the accumulation of microstructural tissue damage in Grey Matter and With Matter, but also better preserve the cognitive profile, particularly by highlighting the benefits in the memory domain. Thanks to drug therapy, brain volume in our patients has remained constant, leading to improvements in memory, indicating teriflunomide as a neuroprotective potential and further strengthening the evidence of a link between loss of brain volume and cognitive impairment.
DOI: 10.5281/zenodo.7737613
title: The role of teriflunomide in Multiple Sclerosis patient: an observational study

description: Teriflunomide is a drug with immunosuppressive and selective immunomodulatory action, characterized by anti-inflammatory and antiproliferative properties. Several clinical studies have demonstrated the efficacy and safety of this drug in Multiple Sclerosis, estimating a significant improvement in cognitive performance.The aim of our study is to evaluate the effects of teriflunomide by analysing the correlation between brain atrophy and the general cognitive profile and evaluating long-term changes. The effect of teriflunomide was studied in 30 patients with multiple sclerosis and 30 control subjects. Patients underwent a full cognitive profile assessment using the Brief Repeatable Battery of Neuropsychological Tests and a neuroimaging examination with a 3.0 T working scanner.Our results suggested that treatment with teriflunomide could potentially not only slow down the accumulation of microstructural tissue damage in Grey Matter and With Matter, but also better preserve the cognitive profile, particularly by highlighting the benefits in the memory domain. Thanks to drug therapy, brain volume in our patients has remained constant, leading to improvements in memory, indicating teriflunomide as a neuroprotective potential and further strengthening the evidence of a link between loss of brain volume and cognitive impairment.
DOI: 10.6084/m9.figshare.22277419
title: Supplementary Material for: Circulating Iron in Patients with Sickle Cell Disease Mediates the Release of Neutrophil Extracellular Traps

description: <b><i>Introduction:</i></b> Neutrophils promote chronic inflammation and release neutrophil extracellular traps (NETs) that can drive inflammatory responses. Inflammation influences progression of sickle cell disease (SCD), and a role for NETs has been suggested in the onset of vaso-occlusive crisis (VOC). We aimed to identify factors in the circulation of these patients that provoke NET release, with a focus on triggers associated with hemolysis. <b><i>Methods:</i></b> Paired serum and plasma samples during VOC and steady state of 18 SCD patients (HbSS/HbSβ<sup>0</sup>-thal and HbSC/HbSβ<sup>+</sup>-thal) were collected. Cell-free heme, hemopexin, and labile plasma iron have been measured in the plasma samples of the SCD patients. NETs formation by human neutrophils from healthy donors induced by serum of SCD patients was studied using confocal microscopy and staining for extracellular DNA using Sytox, followed by quantification of surface coverage using ImageJ. <b><i>Results:</i></b> Eighteen patients paired samples obtained during VOC and steady state were available (11 HbSS/HbSβ<sup>0</sup>-thal and 7 HbSC/HbSβ<sup>+</sup>-thal). We observed high levels of systemic heme and iron, concomitant with low levels of the heme-scavenger hemopexin in sera of patients with SCD, both during VOC and in steady state. In our in vitro experiments, neutrophils released NETs when exposed to sera from SCD patients. The release of NETs was associated with high levels of circulating iron in these sera. Although hemin triggered NET formation in vitro, addition of hemopexin to scavenge heme did not suppress NET release in SCD sera. By contrast, the iron scavengers deferoxamine and apotransferrin attenuated NET formation in a significant proportion of SCD sera. <b><i>Discussion:</i></b> Our results suggest that redox-active iron in the circulation of non-transfusion-dependent SCD patients activates neutrophils to release NETs, and hence, exerts a direct pro-inflammatory effect. Thus, we propose that chelation of iron requires further investigation as a therapeutic strategy in SCD.
DOI: 10.6084/m9.figshare.22277419.v1
title: Supplementary Material for: Circulating Iron in Patients with Sickle Cell Disease Mediates the Release of Neutrophil Extracellular Traps

description: <b><i>Introduction:</i></b> Neutrophils promote chronic inflammation and release neutrophil extracellular traps (NETs) that can drive inflammatory responses. Inflammation influences progression of sickle cell disease (SCD), and a role for NETs has been suggested in the onset of vaso-occlusive crisis (VOC). We aimed to identify factors in the circulation of these patients that provoke NET release, with a focus on triggers associated with hemolysis. <b><i>Methods:</i></b> Paired serum and plasma samples during VOC and steady state of 18 SCD patients (HbSS/HbSβ<sup>0</sup>-thal and HbSC/HbSβ<sup>+</sup>-thal) were collected. Cell-free heme, hemopexin, and labile plasma iron have been measured in the plasma samples of the SCD patients. NETs formation by human neutrophils from healthy donors induced by serum of SCD patients was studied using confocal microscopy and staining for extracellular DNA using Sytox, followed by quantification of surface coverage using ImageJ. <b><i>Results:</i></b> Eighteen patients paired samples obtained during VOC and steady state were available (11 HbSS/HbSβ<sup>0</sup>-thal and 7 HbSC/HbSβ<sup>+</sup>-thal). We observed high levels of systemic heme and iron, concomitant with low levels of the heme-scavenger hemopexin in sera of patients with SCD, both during VOC and in steady state. In our in vitro experiments, neutrophils released NETs when exposed to sera from SCD patients. The release of NETs was associated with high levels of circulating iron in these sera. Although hemin triggered NET formation in vitro, addition of hemopexin to scavenge heme did not suppress NET release in SCD sera. By contrast, the iron scavengers deferoxamine and apotransferrin attenuated NET formation in a significant proportion of SCD sera. <b><i>Discussion:</i></b> Our results suggest that redox-active iron in the circulation of non-transfusion-dependent SCD patients activates neutrophils to release NETs, and hence, exerts a direct pro-inflammatory effect. Thus, we propose that chelation of iron requires further investigation as a therapeutic strategy in SCD.
DOI: 10.6084/m9.figshare.21539931.v2
title: DATA from: Jack pine of all trades: deciphering intraspecific variability of a key adaptive trait at the rear edge of a widespread fire-embracer North American conifer

description: Data from: Jack pine of all trades: deciphering intraspecific variability of a key adaptive trait at the rear edge of a widespread fire-embracer North American conifer. American Journal of Botany. A MSExcel spreadsheet reporting results of 1) an experiment whereby closed jack pine (Pinus banksiana) cones were submitted to incrementing temperatures, and 2) a seed germination tests in order to investigate if and how various ecological factors (cone age, branch height, tree size, tree age) are related to cone dehiscence and seed viability in jack pines from the rear-edge (n = 17 sites) and the core (n = 7 sites) of the species’ range in eastern Canada. <br> <br> Sheet 1 - Metadata. Provides details about the study sites (Region, Site abbreviation, Site name, Sampling date, Longitude, Latitude, Altitude) <br> Sheet 2 - Stand-scale serotiny. At each site, up to 100 mature jack pine individuals were assigned to to one of six serotiny levels: class 0 (0% closed cones), class 1 (1−25% closed cones), class 2 (26−50% closed cones), class 3 (51−75% closed cones), class 4 (76−99% closed cones), or class 5 (100% closed cones). The diameter at breast height (DBH) of each tree sampled for serotiny is also provided in this sheet. <br> Sheet 3 - Experiments. At each site, 10 randomly-chosen mature jack pines were sampled. Three cone-bearing branches from different measured heights (lower, middle, and upper parts of the tree crown) were cut. For each tree, diameter at breast heigth (Tree DBH) was recorded and a core was sampled using a Pressler increment borer as close to the ground as possible. At the laboratory, three fully closed cones of contrasted ages were sampled from each branch (n = 1381 cones). Cone age and tree age was determined by counting growth rings. The cone opening temperatures correspond to the temperature required to reach each opening level, which refers to the relative abundance of opened scales on each individual cone (level 1: 1-25% opening, level 2: 26-50% opening, level 3: 51-75% opening and level 4: 76-100% opening). For each cone, the total number of seeds and the number of filled seeds were recorded. The filled seeds of each cone were batch-weighed. A total of 23,404 seeds were set to germinate. Every day (n = 33 days), germinated seeds (radicle &gt; 2 mm) were counted.
DOI: 10.5281/zenodo.7737532
title: Demo data to evaluate zenodo-govdata integration

description: This data will be used to investigate the feasibility of using Zenodo as a data repository for publishing BMWK data. In particular, the linking of Zenonod with GovData will be examined.
DOI: 10.5281/zenodo.7737531
title: Demo data to evaluate zenodo-govdata integration

description: This data will be used to investigate the feasibility of using Zenodo as a data repository for publishing BMWK data. In particular, the linking of Zenonod with GovData will be examined.
DOI: 10.5281/zenodo.7737626
title: Spreadsheet working analysis (uncleaned): correlation of global warming with Gross World Product (PPP) for 1850–2021

description: This workbook has not been peer-reviewed. Do not cite. Use with caution. For analysis charts see the sheet entitled <em>CHARTS GDP totals and CO2.</em> <strong>Source data:</strong> Gross world product data from:<br> Bolt, J., van Zanden, J.L., 2020. Maddison Project Database 2020 [WWW Document]. Univ. Gron. URL https://www.rug.nl/ggdc/historicaldevelopment/maddison/releases/maddison-project-database-2020 (accessed 11.22.22). Global CO2 data from:<br> CDIAC, 2017. Global, Regional, and National Fossil-Fuel CO2 Emissions. Carbon Dioxide Information Analysis Center.<br> Friedlingstein, P., O’Sullivan, M., Jones, M.W., Andrew, R.M., Gregor, L., Hauck, J., Le Quéré, C., Luijkx, I.T., Olsen, A., Peters, G.P., Peters, W., Pongratz, J., Schwingshackl, C., Sitch, S., Canadell, J.G., Ciais, P., Jackson, R.B., Alin, S.R., Alkama, R., Arneth, A., Arora, V.K., Bates, N.R., Becker, M., Bellouin, N., Bittig, H.C., Bopp, L., Chevallier, F., Chini, L.P., Cronin, M., Evans, W., Falk, S., Feely, R.A., Gasser, T., Gehlen, M., Gkritzalis, T., Gloege, L., Grassi, G., Gruber, N., Gürses, Ö., Harris, I., Hefner, M., Houghton, R.A., Hurtt, G.C., Iida, Y., Ilyina, T., Jain, A.K., Jersild, A., Kadono, K., Kato, E., Kennedy, D., Klein Goldewijk, K., Knauer, J., Korsbakken, J.I., Landschützer, P., Lefèvre, N., Lindsay, K., Liu, J., Liu, Z., Marland, G., Mayot, N., McGrath, M.J., Metzl, N., Monacci, N.M., Munro, D.R., Nakaoka, S.-I., Niwa, Y., O’Brien, K., Ono, T., Palmer, P.I., Pan, N., Pierrot, D., Pocock, K., Poulter, B., Resplandy, L., Robertson, E., Rödenbeck, C., Rodriguez, C., Rosan, T.M., Schwinger, J., Séférian, R., Shutler, J.D., Skjelvan, I., Steinhoff, T., Sun, Q., Sutton, A.J., Sweeney, C., Takao, S., Tanhua, T., Tans, P.P., Tian, X., Tian, H., Tilbrook, B., Tsujino, H., Tubiello, F., van der Werf, G.R., Walker, A.P., Wanninkhof, R., Whitehead, C., Willstrand Wranne, A., Wright, R., Yuan, W., Yue, C., Yue, X., Zaehle, S., Zeng, J., Zheng, B., 2022. Global Carbon Budget 2022. Earth Syst. Sci. Data 14, 4811–4900. https://doi.org/10.5194/essd-14-4811-2022
description: Uncleaned rough working draft workbook archived as the source for a working analysis entitled No sign of effective climate action: global warming remains strongly coupled to gross world product
DOI: 10.5281/zenodo.7737625
title: Spreadsheet working analysis (uncleaned): correlation of global warming with Gross World Product (PPP) for 1850–2021

description: This workbook has not been peer-reviewed. Do not cite. Use with caution. For analysis charts see the sheet entitled <em>CHARTS GDP totals and CO2.</em> <strong>Source data:</strong> Gross world product data from:<br> Bolt, J., van Zanden, J.L., 2020. Maddison Project Database 2020 [WWW Document]. Univ. Gron. URL https://www.rug.nl/ggdc/historicaldevelopment/maddison/releases/maddison-project-database-2020 (accessed 11.22.22). Global CO2 data from:<br> CDIAC, 2017. Global, Regional, and National Fossil-Fuel CO2 Emissions. Carbon Dioxide Information Analysis Center.<br> Friedlingstein, P., O’Sullivan, M., Jones, M.W., Andrew, R.M., Gregor, L., Hauck, J., Le Quéré, C., Luijkx, I.T., Olsen, A., Peters, G.P., Peters, W., Pongratz, J., Schwingshackl, C., Sitch, S., Canadell, J.G., Ciais, P., Jackson, R.B., Alin, S.R., Alkama, R., Arneth, A., Arora, V.K., Bates, N.R., Becker, M., Bellouin, N., Bittig, H.C., Bopp, L., Chevallier, F., Chini, L.P., Cronin, M., Evans, W., Falk, S., Feely, R.A., Gasser, T., Gehlen, M., Gkritzalis, T., Gloege, L., Grassi, G., Gruber, N., Gürses, Ö., Harris, I., Hefner, M., Houghton, R.A., Hurtt, G.C., Iida, Y., Ilyina, T., Jain, A.K., Jersild, A., Kadono, K., Kato, E., Kennedy, D., Klein Goldewijk, K., Knauer, J., Korsbakken, J.I., Landschützer, P., Lefèvre, N., Lindsay, K., Liu, J., Liu, Z., Marland, G., Mayot, N., McGrath, M.J., Metzl, N., Monacci, N.M., Munro, D.R., Nakaoka, S.-I., Niwa, Y., O’Brien, K., Ono, T., Palmer, P.I., Pan, N., Pierrot, D., Pocock, K., Poulter, B., Resplandy, L., Robertson, E., Rödenbeck, C., Rodriguez, C., Rosan, T.M., Schwinger, J., Séférian, R., Shutler, J.D., Skjelvan, I., Steinhoff, T., Sun, Q., Sutton, A.J., Sweeney, C., Takao, S., Tanhua, T., Tans, P.P., Tian, X., Tian, H., Tilbrook, B., Tsujino, H., Tubiello, F., van der Werf, G.R., Walker, A.P., Wanninkhof, R., Whitehead, C., Willstrand Wranne, A., Wright, R., Yuan, W., Yue, C., Yue, X., Zaehle, S., Zeng, J., Zheng, B., 2022. Global Carbon Budget 2022. Earth Syst. Sci. Data 14, 4811–4900. https://doi.org/10.5194/essd-14-4811-2022
description: Uncleaned rough working draft workbook archived as the source for a working analysis entitled No sign of effective climate action: global warming remains strongly coupled to gross world product