cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.4929524
title: Supplementary Material for: Pre-ESRD Dementia and Post-ESRD Mortality in a Large Cohort of Incident Dialysis Patients

description: <b><i>Background:</i></b> Conservative management may be a desirable option for elderly, fragile, or demented patients who reach end-stage renal disease (ESRD), yet some patients with dementia are placed on renal replacement therapy nonetheless. <b><i>Methods:</i></b> From a nationwide cohort of 45,076 US veterans who transitioned to ESRD over 4 contemporary years (October 1, 2007 to September 30, 2011), we identified 1,336 (3.0%) patients with International Classification of Diseases, Ninth Revision, Clinical Modification code-based dementia diagnosis during the prelude (predialysis) period. We examined the association of prelude dementia with all-cause mortality within the first 6 months following transition to dialysis, using a propensity-matched cohort and Cox proportional hazards models. <b><i>Results:</i></b> In the entire cohort, the overall mean ± standard deviation age at baseline was 72 ± 11 years, 95% were male, 23% were African-American, and 66% were diabetic. There were 8,080 (18.5%) deaths (mortality rate, 412; 95% confidence interval [CI], 403-421/1,000 patient-years) in the dementia-negative group, and 396 (29.6%) deaths (mortality rate, 708; 95% CI, 642-782/1,000 patient-years) in the dementia-positive group in the entire cohort in the first 6 months after dialysis initiation. Presence of dementia was associated with higher risk of all-cause mortality (adjusted hazard ratio, 1.25; 95% CI, 1.12-1.38) compared to dementia-free patients in the first 6 months after dialysis initiation. <b><i>Conclusion:</i></b> Pre-ESRD dementia is associated with increased risk of early post-ESRD mortality in veterans transitioning to dialysis.
DOI: 10.6084/m9.figshare.4929533.v1
title: Supplementary Material for: Changing Epidemiological Patterns in Traumatic Brain Injury: A Longitudinal Hospital-Based Study in Belgium

description: <b><i>Background:</i></b> Various reports have suggested that epidemiological patterns of Traumatic Brain Injury (TBI) are changing in high-income countries, but the evidence to support this is often indirect and only a few longitudinal studies exist. We aimed to explore epidemiological patterns of TBI in Belgium over a 10-year period. <b><i>Methods:</i></b> A retrospective analysis of Minimum Hospital Data provided by Statistics Belgium was performed for the period 2003-2012. ICD-9 classification was used to identify TBI and to differentiate subtypes. The annual incidence of hospital admissions and in-hospital mortality rates were calculated and further differentiated for age, gender and cause of injury. <b><i>Results:</i></b> The age-adjusted incidence of hospital admissions decreased by 3.6% per year. An increase in the number of elderly patients with TBI and a decrease in the younger age groups were found. Falls now represent the main cause of TBI. A mortality rate of 6.5 per 100,000 population per year was found and did not change significantly over time. <b><i>Conclusions:</i></b> This longitudinal study confirms that epidemiological patterns in TBI are changing: overall incidence is steadily decreasing, but in elderly patients, the incidence is increasing. Falls are the leading cause, occurring most frequently in elderly patients. These changes are relevant for prevention.
DOI: 10.6084/m9.figshare.4929530.v1
title: Supplementary Material for: Purification and Biochemical and Kinetic Properties of an Endo-Polygalacturonase from the Industrial Fungus Aspergillus sojae

description: An endo-polygalacturonase secreted by <i>Aspergillus sojae </i>was characterized after being purified to homogeneity from submerged cultures with orange peel as the sole carbon source by gel filtration and ion-exchange chromatographies. According to SDS-PAGE and analytical isoelectric focusing analyses, the enzyme presents a molecular weight of 47 kDa and pI value of 4.2. This enzyme exhibits considerable stability under highly acidic to neutral conditions (pH 1.5-6.5) and presents a half-life of 2 h at 50°C. Besides its activity towards pectin and polygalacturonic acid, the enzyme displays pectin-releasing activity, acting best in a pH range of 3.3-5.0. Thin-layer chromatographic analysis revealed that tri-galacturonate is the main enzymatic end product of polygalacturonic acid hydrolysis, indicating that it is an endo-polygalacturonase. The enzyme exhibits Michaelis-Menten kinetics, with K<sub>M</sub> and V<sub>MAX</sub> values of 0.134 mg/mL and 9.6 µmol/mg/min, respectively, and remained stable and active in the presence of SO<sub>2</sub>, ethanol, and various cations assayed except Hg<sup>2+</sup>.
DOI: 10.6084/m9.figshare.4929518
title: Dataset for: Cellular distribution and function of ion channels involved in transport processes in rat tracheal epithelium

description: Transport of water and electrolytes in airway epithelia involves chloride-selective ion channels, which are controlled either by cytosolic Ca2+ or by cAMP. The contributions of the two pathways to chloride transport differ among vertebrate species. Because rats are becoming more important as animal model for cystic fibrosis, we have examined how Ca2+- dependent and cAMP- dependent Cl- secretion is organized in the rat tracheal epithelium. We examined the expression of the Ca2+-gated Cl- channel anoctamin 1 (ANO1), the cystic fibrosis transmembrane conductance regulator (CFTR) Cl- channel, the epithelial Na+ channel ENaC, and the water channel aquaporin 5 (AQP5) in rat tracheal epithelium. The contribution of ANO1 channels to nucleotide-stimulated Cl- secretion was determined using the channel blocker Ani9 in short-circuit current recordings obtained from primary cultures of rat tracheal epithelial cells in Ussing chambers. We found that ANO1, CFTR and AQP5 proteins were expressed in non-ciliated cells of the tracheal epithelium, whereas ENaC was expressed in ciliated cells. Among non-ciliated cells, ANO1 occurred together with CFTR and Muc5b and, in addition, in a different cell type without CFTR and Muc5b. Bioelectrical studies with the ANO1-blocker Ani9 indicated that ANO1 mediated the secretory response to the nucleotide uridine-5'-triphosphate. Our data demonstrate that, in rat tracheal epithelium, Cl- secretion and Na+ absorption are routed through different cell types, and that ANO1 channels form the molecular basis of Ca2+-dependent Cl- secretion in this tissue. These characteristic features of Cl--dependent secretion reveal similarities and distinct differences to secretory processes in the human airways.
DOI: 10.6084/m9.figshare.4929515
title: Supplementary Material for: Efficacy, Safety, and Tolerability of Armodafinil Therapy for Hypersomnia Associated with Dementia with Lewy Bodies: A Pilot Study

description: <b><i>Background/Aims:</i></b> Hypersomnia is common in dementia with Lewy bodies (DLB). We assessed the efficacy, safety, and tolerability of armodafinil for hypersomnia associated with DLB. <b><i>Methods:</i></b> We performed a 12-week pilot trial of armodafinil therapy (125-250 mg orally daily) in DLB outpatients with hypersomnia. The patients underwent neurologic examinations, a neuropsychological battery, laboratory testing, electrocardiography, and polysomnography. Efficacy was assessed at 2, 4, 8, and 12 weeks. Safety assessment included laboratory examinations, QTc interval, and heart rate. Tolerability was assessed by analysis of adverse events. Data were analyzed using the last-observation-carried-forward method. <b><i>Results:</i></b> Of 20 participants, 17 completed the protocol. The median age was 72 years, most of the participants were men (80%), and most had spouses as caregivers. The Epworth Sleepiness Scale (<i>p</i> &lt; 0.001), Maintenance of Wakefulness Test (<i>p</i> = 0.003), and Clinical Global Impression of Change (<i>p</i> &lt; 0.001) scores improved at week 12. The Neuropsychiatric Inventory total score (<i>p</i> = 0.003), visual hallucinations (<i>p</i> = 0.003), and agitation (<i>p</i> = 0.02) improved at week 4. Caregiver overall quality of life improved at week 12 (<i>p</i> = 0.004). No adverse events occurred. <b><i>Conclusion:</i></b> These pilot data suggest improvements in hypersomnia and wakefulness and reasonable safety and tolerability of armodafinil therapy in hypersomnolent patients with DLB. Our findings inform the use of pharmacologic strategies for managing hypersomnolence in these patients.
DOI: 10.6084/m9.figshare.4929506
title: Supplementary Material for: Altered Expression of Hippo Signaling Pathway Molecules in Intrahepatic Cholangiocarcinoma

description: <b><i>Objective:</i></b> MOB1, a core component of the Hippo signaling pathway, suppresses cell proliferation, and MOB1 liver conditional knockout mice develop intrahepatic cholangiocarcinoma (ICC). However, its clinical significance in human ICC has not been established. The aim of this study was to characterize protein levels and the role of Hippo and TGF pathways in ICCs. <b><i>Methods:</i></b> The protein levels of yes-associated protein 1 (YAP1), MOB1, Smad2, and TGFβ2 in 88 ICC cases were analyzed. Protein level was graded by a scoring system; then, the clinicopathological factors, including prognosis, were analyzed based on protein level. <b><i>Results:</i></b> Nuclear overexpression of YAP1 was seen in 28 cases (31.8%), and it was significantly associated with a poor overall survival rate (<i>p</i> = 0.01). MOB1 expression decreased in 42 cases (47.7%) and was associated with a poor overall survival rate (<i>p</i> = 0.02). SMAD2 nuclear localization was significantly correlated with a high YAP1 level independent of TGFβ2. Multivariate analysis revealed that a high YAP1 level, a low MOB1 level, and lymphatic permeation were independent risk factors for overall survival. <b><i>Conclusions:</i></b> These results showed that key components of the Hippo signaling pathway are aberrantly expressed and associated with the malignant potential of human ICC.
DOI: 10.6084/m9.figshare.4929518.v1
title: Dataset for: Cellular distribution and function of ion channels involved in transport processes in rat tracheal epithelium

description: Transport of water and electrolytes in airway epithelia involves chloride-selective ion channels, which are controlled either by cytosolic Ca2+ or by cAMP. The contributions of the two pathways to chloride transport differ among vertebrate species. Because rats are becoming more important as animal model for cystic fibrosis, we have examined how Ca2+- dependent and cAMP- dependent Cl- secretion is organized in the rat tracheal epithelium. We examined the expression of the Ca2+-gated Cl- channel anoctamin 1 (ANO1), the cystic fibrosis transmembrane conductance regulator (CFTR) Cl- channel, the epithelial Na+ channel ENaC, and the water channel aquaporin 5 (AQP5) in rat tracheal epithelium. The contribution of ANO1 channels to nucleotide-stimulated Cl- secretion was determined using the channel blocker Ani9 in short-circuit current recordings obtained from primary cultures of rat tracheal epithelial cells in Ussing chambers. We found that ANO1, CFTR and AQP5 proteins were expressed in non-ciliated cells of the tracheal epithelium, whereas ENaC was expressed in ciliated cells. Among non-ciliated cells, ANO1 occurred together with CFTR and Muc5b and, in addition, in a different cell type without CFTR and Muc5b. Bioelectrical studies with the ANO1-blocker Ani9 indicated that ANO1 mediated the secretory response to the nucleotide uridine-5'-triphosphate. Our data demonstrate that, in rat tracheal epithelium, Cl- secretion and Na+ absorption are routed through different cell types, and that ANO1 channels form the molecular basis of Ca2+-dependent Cl- secretion in this tissue. These characteristic features of Cl--dependent secretion reveal similarities and distinct differences to secretory processes in the human airways.
DOI: 10.6084/m9.figshare.4929506.v1
title: Supplementary Material for: Altered Expression of Hippo Signaling Pathway Molecules in Intrahepatic Cholangiocarcinoma

description: <b><i>Objective:</i></b> MOB1, a core component of the Hippo signaling pathway, suppresses cell proliferation, and MOB1 liver conditional knockout mice develop intrahepatic cholangiocarcinoma (ICC). However, its clinical significance in human ICC has not been established. The aim of this study was to characterize protein levels and the role of Hippo and TGF pathways in ICCs. <b><i>Methods:</i></b> The protein levels of yes-associated protein 1 (YAP1), MOB1, Smad2, and TGFβ2 in 88 ICC cases were analyzed. Protein level was graded by a scoring system; then, the clinicopathological factors, including prognosis, were analyzed based on protein level. <b><i>Results:</i></b> Nuclear overexpression of YAP1 was seen in 28 cases (31.8%), and it was significantly associated with a poor overall survival rate (<i>p</i> = 0.01). MOB1 expression decreased in 42 cases (47.7%) and was associated with a poor overall survival rate (<i>p</i> = 0.02). SMAD2 nuclear localization was significantly correlated with a high YAP1 level independent of TGFβ2. Multivariate analysis revealed that a high YAP1 level, a low MOB1 level, and lymphatic permeation were independent risk factors for overall survival. <b><i>Conclusions:</i></b> These results showed that key components of the Hippo signaling pathway are aberrantly expressed and associated with the malignant potential of human ICC.
DOI: 10.6084/m9.figshare.4929470
title: Neighborhood density and travel mode: new survey findings for high densities

description: At high densities, land uses get close enough to each other to support walk, bike, and transit modes above 60% of total trips. The San Francisco Bay Area census was used to define five density levels: rural, exurban, suburban, central city, and urban core. The urban core definition, over 50 persons per neighborhood acre, is much denser than in other research. The California Household Transportation Survey supplied new data on block group area, population, trip stages, trip distances, trip time, and travel mode by density. The National Household Transportation Survey supplied block group population, density, travel mode, and income data. Both sources show a strong nonlinear relationship going from rural to urban core: auto miles and trips decrease as walk and transit miles and trips increase. With density, people travel fewer miles and spend less time traveling. High-income households in dense areas travel far fewer miles than those living at higher densities. With sufficient density, complementary features play a role in furthering mode shift. For planning purposes, the need for parking greatly declines. The findings are a basis for similar research elsewhere on high densities and complementary features.
DOI: 10.6084/m9.figshare.4929470.v1
title: Neighborhood density and travel mode: new survey findings for high densities

description: At high densities, land uses get close enough to each other to support walk, bike, and transit modes above 60% of total trips. The San Francisco Bay Area census was used to define five density levels: rural, exurban, suburban, central city, and urban core. The urban core definition, over 50 persons per neighborhood acre, is much denser than in other research. The California Household Transportation Survey supplied new data on block group area, population, trip stages, trip distances, trip time, and travel mode by density. The National Household Transportation Survey supplied block group population, density, travel mode, and income data. Both sources show a strong nonlinear relationship going from rural to urban core: auto miles and trips decrease as walk and transit miles and trips increase. With density, people travel fewer miles and spend less time traveling. High-income households in dense areas travel far fewer miles than those living at higher densities. With sufficient density, complementary features play a role in furthering mode shift. For planning purposes, the need for parking greatly declines. The findings are a basis for similar research elsewhere on high densities and complementary features.
DOI: 10.7935/1502-wj52
title: LIGO Virgo strain data from GW190521 event
DOI: 10.6084/m9.figshare.4928993
title: Presence of B. thailandensis and B. thailandensis expressing B. pseudomallei-like capsular polysaccharide in Thailand, and their associations with serological response to B. pseudomallei

description: The data provided comprises of bacterial culture results for the three organisms (positive/negative), soil physiochemical properties and location information (GPS coordinates, province, region and country) of 61 rice fields in Thailand, and antibodies against <i>B. pseudomallei</i> measured by an indirect haemagglutination assay (IHA) of 92 rice farmers who worked in the sampled rice fields. Sixty one rice field located in 61 villages from the East (19), Central (21) and the Northeast (21) Thailand were randomly selected. Soil was sampled in the dry season (April-June) in 2013, 2014, 2015. In each rice field, gird of 10x10 grid (2.5m apart) was plotted to generate 100 sampling points. We collected 20 grams of soil, 10g for culture for <i>B. thailandensis</i>, BTCV variant and <i>B. pseudomallei</i> and another 10g was for soil physiochemical properties tests. The positive rice field is the field that at least one sample was positive for each organism. An indirect haemagglutination assay (IHA) was used to detect antibodies against <i>B. pseudomallei </i>as described previously (Ileri et al. 1975, Alexander et al. 1970). Blood samples from rice farmers whom worked in the sampled rice fields for within 12 months prior to the sampling date were collected. An IHA titre of &lt;1:80 was define as negative. The study protocol was approved by the Ethics Committee of the Faculty of Tropical Medicine, Mahidol University (MUTM2013-021-01) and the Oxford Tropical Research Ethics Committee, University of Oxford (OXTREC 1013-13). There are two data files, the first file (Data1of2) contains bacterial culture results and soil physicochemical properties. Each row represents presence of <i>B. thailandensis</i>, BTCV and <i>B. pseudomallei</i> and soil characteristics per sampled site. For the second file (Data2of2), each row represents antibodies against <i>B. pseudomallei</i> per each farmer whom exposed to sampled rice fields. In addition, demographic information of farmers (age, gender) and known diagnosis of diabetes militus are also provided in the Data2of2. Please see the data dictionary for descriptions of each variable.
DOI: 10.6084/m9.figshare.4928990
title: Data for "Extrafloral nectar secretion is mainly determined by carbon fixation under herbivore-free condition in the tropical shrub Clerodendrum philippinum var. simplex"

description: The plant EFN secretion rate can be best explained by plant carbon fixation. EFN secretion was correlated positively to photosynthesis rate at both plant and leaf levels, but negatively to leaf age at leaf level. <br>
DOI: 10.6084/m9.figshare.4928993.v1
title: Presence of B. thailandensis and B. thailandensis expressing B. pseudomallei-like capsular polysaccharide in Thailand, and their associations with serological response to B. pseudomallei

description: The data provided comprises of bacterial culture results for the three organisms (positive/negative), soil physiochemical properties and location information (GPS coordinates, province, region and country) of 61 rice fields in Thailand, and antibodies against <i>B. pseudomallei</i> measured by an indirect haemagglutination assay (IHA) of 92 rice farmers who worked in the sampled rice fields. Sixty one rice field located in 61 villages from the East (19), Central (21) and the Northeast (21) Thailand were randomly selected. Soil was sampled in the dry season (April-June) in 2013, 2014, 2015. In each rice field, gird of 10x10 grid (2.5m apart) was plotted to generate 100 sampling points. We collected 20 grams of soil, 10g for culture for <i>B. thailandensis</i>, BTCV variant and <i>B. pseudomallei</i> and another 10g was for soil physiochemical properties tests. The positive rice field is the field that at least one sample was positive for each organism. An indirect haemagglutination assay (IHA) was used to detect antibodies against <i>B. pseudomallei </i>as described previously (Ileri et al. 1975, Alexander et al. 1970). Blood samples from rice farmers whom worked in the sampled rice fields for within 12 months prior to the sampling date were collected. An IHA titre of &lt;1:80 was define as negative. The study protocol was approved by the Ethics Committee of the Faculty of Tropical Medicine, Mahidol University (MUTM2013-021-01) and the Oxford Tropical Research Ethics Committee, University of Oxford (OXTREC 1013-13). There are two data files, the first file (Data1of2) contains bacterial culture results and soil physicochemical properties. Each row represents presence of <i>B. thailandensis</i>, BTCV and <i>B. pseudomallei</i> and soil characteristics per sampled site. For the second file (Data2of2), each row represents antibodies against <i>B. pseudomallei</i> per each farmer whom exposed to sampled rice fields. In addition, demographic information of farmers (age, gender) and known diagnosis of diabetes militus are also provided in the Data2of2. Please see the data dictionary for descriptions of each variable.
DOI: 10.4225/03/5902b67f2f229
title: Duffy_et_al_AntarcticSDM_DDI_results

description: <b>Supplementary data for Duffy et al., 2017, Barriers to globally invasive species are weakening across the Antarctic, <i>Diversity & Distributions</i>, doi:10.1111/ddi.12593.</b><br>Species distribution modelling results for a full 10-model ensemble for 69 globally invasive species and 24 cold-tolerant species under current and future climate conditions. <br>Models are named by species and compressed using the 7-zip file format.
DOI: 10.6084/m9.figshare.4928990.v4
title: Data for "Extrafloral nectar secretion is mainly determined by carbon fixation under herbivore-free condition in the tropical shrub Clerodendrum philippinum var. simplex"

description: The plant EFN secretion rate can be best explained by plant carbon fixation. EFN secretion was correlated positively to photosynthesis rate at both plant and leaf levels, but negatively to leaf age at leaf level. <br>
DOI: 10.6084/m9.figshare.4928900
title: Sub-volcanic xenoliths from Raoul Volcano: a window on petrogenetic processes in an intra-oceanic subduction system

description: Gabbroic and tonalitic xenoliths from c. 3 ka pyroclastic deposits on Raoul Island in the intra-oceanic Kermadec arc are samples of shallow crust formed 2 and incompatible trace element abundances are lower. The rare earth element (REE) patterns of the gabbros manifest strong positive Eu anomalies indicative of cumulate plagioclase. Tonalitic xenoliths comprise plagioclase, quartz, magnesiohornblende, magnetite, ilmenite and titanite. Their REE patterns feature strong negative Eu anomalies, which could indicate extensive plagioclase fractionation, but some have orthocumulate textures. In contrast to Raoul dacites, tonalitic xenoliths commonly contain amphibole. They also have higher total REE, and lower K, Ba and Rb abundances, and more evolved Sr isotope compositions. They represent a spectrum from highly fractionated felsic melts, through crystal mushes to felsic cumulates and were generated during an earlier phase in the evolution of the Raoul magmatic system.