DOI: 10.5281/zenodo.15059617
title: Data (A wireless device for continuous measurement of brain parenchymal resistance tracks glymphatic function in humans)

description: To access the data, please complete the Data User Agreement by filling out the form provided in the link below. 

https://tinyurl.com/appliedcognition-dua

Once completed, kindly send it to research@appliedcognition.com along with your Zenodo ID for processing.
description: Hypnogram.csv

This file contains the hypnogram labels for every epoch and every sleep recording, labeled by a sleep neurologist as well as the labelling from the Applied Cognition investigational device. The sleep neurologist used all the polysomnography (PSG) channels for hypnogram labeling. The Applied Cognition device used its acquired EEG channel. 





ID: Unique id created from study identifier + participant identifier + sleep period




Channel: Label indicating label by the sleep neurologist reading the full PSG (“human”), algorithmic labeling using device or PSG single channels derivatives




Hypnogram: Hypnogram label



 

samples_morning.csv / samples_night.csv / samples_night_keep_waso.csv

These files contain device data at the block level. A block is approximately 300sec long of device recording that multiplexes EEG recordings with EIS recordings. Data in samples_night_keep_waso.csv file include the “wake after sleep onset” blocks.





Study: Study identifier (Benchmarking / Replication)




ID: Unique identifier created from study identifier + participant identifier + sleep period (morning/night)




Pid: Participant identifier




Visit: Visit number (visit 1 or visit 2)




Intervention: Random assignment to sleep/wake




Sleep: Set to true for sleep intervention




Block Number: Block number




Timestamp: Block start timestamp




Block hypnogram: Hypnogram label assigned to the block using EEG epochs. Hypnogram labels mapping: 0: Wake, 1: N1,  2: N2, 3: N3, 4: REM




dR: Change in resistance from previous block to current block




dDelta: Change in delta power from previous block to current block




dTheta: Change in theta power from previous block to current block




dAlpha: Change in alpha power from previous block to current block




dBeta: Change in beta power from previous block to current block




dGamma: Change in gamma power from previous block to current block




dHR: Change in heart rate from previous block to current block




dLFHFRatio: Change in the HRV ratio of LF and HF from previous block to current block




Dz_ref: Change in electrode impedance of sense electrode (right side) from previous block to current block




Dz_eeg: Change in electrode impedance of sense electrode (left side) from previous block to current block




Dz_bias_drvp: Change in electrode impedance of drive electrode (left side) from previous block to current block




Dz_drvn: Change in electrode impedance of reference electrode (right side) from previous block to current block




dHypno: Change in Hypnogram label from previous block to current block (eg. 2->3)




Resistance: Parenchymal resistance




Resistance_Norm_Factor: Parenchymal resistance starting normalization




Resistance_End_Avg: Parenchymal resistance ending value



 

Summary.csv

This file contains aggregated data for every participant’s visit. This file contains participant information, aggregated device data, MRI data, APOE4 status and screening assessments (MoCa & GDS)

 

Visit and Participant Columns

General visit information and participant details.





Study: Study identifier




Pid: Participant identifier




Visit: Visit number (v1 or v2)




Visit_type: Random assignment to sleep/wake




Age: Participant’s age




Gender: Participant’s gender



 

Device Columns

Data aggregated for each visit with one record per visit. For example, the change in parenchymal resistance for the overnight recording (in the interval between period 1 to period 2) is “Resistance_p1-p2”. Similarly, for the morning recording (interval between period 2 to period 3), the change in parenchymal resistance is “Resistance_p2-p3”.





Visit_p1-p2: Recording identifier of the overnight period (p1-p2)




Resistance_p1-p2: Overnight change in parenchymal resistance




Resistance_p2-p3: Morning change in parenchymal resistance




delta rel_p1-p2: Overnight average delta power normalized to values at start of overnight period




delta rel_p2-p3: Morning average delta power normalized to values at start of morning period




theta rel_p1-p2: Overnight average theta power normalized to values at start of overnight period




theta rel_p2-p3: Morning average theta power normalized to values at start of morning period




alpha rel_p1-p2: Overnight average alpha power normalized to values at start of overnight period




alpha rel_p2-p3: Morning average alpha power normalized to values at start of morning period




beta rel_p1-p2: Overnight average beta power normalized to values at start of overnight period




beta rel_p2-p3: Morning average beta power normalized to values at start of morning period




heart rate_p1-p2: Overnight average heart rate normalized to values at start of overnight period




heart rate_p2-p3: Morning average heart rate normalized to values at start of morning period




N1_p1-p2: Total time in minutes the participant was in N1 sleep overnight computed using the device EEG 




N2_p1-p2: Total time in minutes the participant was in N2 sleep overnight computed using the device EEG 




N3_p1-p2: Total time in minutes the participant was in N3 sleep overnight computed using the device EEG 




REM_p1-p2: Total time in minutes the participant was in REM sleep overnight computed using the device EEG 




WASO_p1-p2: Total time in minutes the participant was in WASO overnight computed using the device EEG 




N1_p2-p3: Total time in minutes the participant was in N1 sleep during the morning visit computed using the device EEG 




N2_p2-p3: Total time in minutes the participant was in N2 sleep during the morning visit computed using the device EEG 




N3_p2-p3: Total time in minutes the participant was in N3 sleep during the morning visit computed using the device EEG 




REM_p2-p3: Total time in minutes the participant was in REM sleep during the morning visit computed using the device EEG 




WASO_p2-p3: Total time in minutes the participant was in WASO during the morning visit computed using the device EEG




EEG Sample Time %_p1: Percentage of time that was spent doing EEG sampling. It is fixed per recording.



 

Polysomnography columns

The columns contain the total time in minutes the participant was in the N1, N2, N3, REM and WASO stages using polysomnography channel C4 either for overnight sleep (visit_type = Sleep) or morning sleep (visit_type = Awake)





C4 N1: Total time in minutes the participant was in N1 sleep




C4 N2: Total time in minutes the participant was in N2 sleep




C4 N3: Total time in minutes the participant was in N3 sleep




C4 REM: Total time in minutes the participant was in REM sleep




C4 WASO: Total time in minutes the participant was in WASO



 

Screening Assessment





MoCA: Montreal Cognitive Assessment




GDS: Geriatric Depression Scale



 

APOEe4



APOEe4: Boolean flag set to true in the presence of at least one copy of APOEe4


 

MRI Columns





CSF Max_Vel_p1: Absolute maximum velocity of CSF in Aqueduct of Sylvius at time point p1




CSF Max_Vel_p2:Absolute maximum velocity of CSF in Aqueduct of Sylvius at time point p2




CSF Max_Vel_p3: Absolute maximum velocity of CSF in Aqueduct of Sylvius at time point p3




Dstr Frontal _p1: Pseudodiffusion coefficient in frontal gray matter in mm2/s at time point p1




Dstr Frontal GM_p2: Pseudodiffusion coefficient in frontal gray matter in mm2/s at time point p2




Dstr Frontal GM_p3: Pseudodiffusion coefficient in frontal gray matter in mm2/s at time point p3




Dstr Frontal WM_p1: Pseudodiffusion coefficient in frontal white matter in mm2/s at time point p1




Dstr Frontal WM_p2: Pseudodiffusion coefficient in frontal white matter in mm2/s at time point p2




Dstr Frontal WM_p3: Pseudodiffusion coefficient in frontal white matter in mm2/s at time point p3




Dstr Parietal GM_p1: Pseudodiffusion coefficient in parietal gray matter in mm2/s at time point p1




Dstr Parietal GM_p2: Pseudodiffusion coefficient in parietal gray matter in mm2/s at time point p2




Dstr Parietal GM_p3: Pseudodiffusion coefficient in parietal gray matter in mm2/s at time point p3




Dstr Parietal WM_p1:Pseudodiffusion coefficient in parietal white matter in mm2/s at time point p1




Dstr Parietal WM_p2: Pseudodiffusion coefficient in parietal white matter in mm2/s at time point p2




Dstr Parietal WM_p3: Pseudodiffusion coefficient in parietal white matter in mm2/s at time point p3




Dstr Temporal GM_p1: Pseudodiffusion coefficient in temporal gray matter in mm2/s at time point p1




Dstr Temporal GM_p2: Pseudodiffusion coefficient in temporal gray matter in mm2/s at time point p2




Dstr Temporal GM_p3: Pseudodiffusion coefficient in temporal gray matter in mm2/s at time point p3




Dstr Temporal WM_p1: Pseudodiffusion coefficient in temporal white matter in mm2/s at time point p1




Dstr Temporal WM_p2: Pseudodiffusion coefficient in temporal white matter in mm2/s at time point p2




Dstr Temporal WM_p3: Pseudodiffusion coefficient in temporal white matter in mm2/s at time point p3




Dstr Occipital GM_p1: Pseudodiffusion coefficient in occipital gray matter in mm2/s at time point p1




Dstr Occipital GM_p2: Pseudodiffusion coefficient in occipital gray matter in mm2/s at time point p2




Dstr Occipital GM_p3: Pseudodiffusion coefficient in occipital gray matter in mm2/s at time point p2




Dstr Occipital WM_p1: Pseudodiffusion coefficient in occipital white matter in mm2/s at time point p1




Dstr Occipital WM_p2: Pseudodiffusion coefficient in occipital white matter in mm2/s at time point p2




Dstr Occipital WM_p3: Pseudodiffusion coefficient in occipital white matter in mm2/s at time point p3




Dstr SAS_p1: Pseudodiffusion coefficient in the subarachnoid CSF in mm2/s at time point p1




Dstr SAS_p2: Pseudodiffusion coefficient in the subarachnoid CSF in mm2/s at time point p2




Dstr SAS_p3: Pseudodiffusion coefficient in the subarachnoid CSF in mm2/s at time point p3




f SAS_p1: fluid fraction of the subarachnoid space corresponding to Dstr SAS_p1 at time point p1




f SAS_p2: fluid fraction of the subarachnoid space corresponding to Dstr SAS_p1 at time point p2




f SAS_p3: fluid fraction of the subarachnoid space corresponding to Dstr SAS_p1 at time point p3




fDstr SAS_p1: Product of f SAS_p1 and Dstr SAS_p1




fDstr SAS_p2: Product of f SAS_p2 and Dstr SAS_p2




fDstr SAS_p3: Product of f SAS_p3 and Dstr SAS_p3




Cortical CBF_p1: Cortical cerebral blood flow at time point p1




Cortical CBF_p2: Cortical cerebral blood flow at time point p2




Cortical CBF_p3: Cortical cerebral blood flow at time point p3




Frontal CBF_p1: Gray matter cerebral blood flow at time point p1 in the frontal lobe




Frontal CBF_p2: Gray matter cerebral blood flow at time point p2 in the frontal lobe




Frontal CBF_p3: Gray matter cerebral blood flow at time point p3 in the frontal lobe




Parietal CBF_p1: Gray matter cerebral blood flow at time point p1 in the parietal lobe




Parietal CBF_p2: Gray matter cerebral blood flow at time point p2 in the parietal lobe




Parietal CBF_p3: Gray matter cerebral blood flow at time point p3 in the parietal lobe




Temporal CBF_p1: Gray matter cerebral blood flow at time point p1 in the temporal lobe




Temporal CBF_p2: Gray matter cerebral blood flow at time point p2 in the temporal lobe




Temporal CBF_p3: Gray matter cerebral blood flow at time point p3 in the temporal lobe




Occipital CBF_p1: Gray matter cerebral blood flow at time point p1 in the occipital lobe




Occipital CBF_p2: Gray matter cerebral blood flow at time point p2 in the occipital lobe




Occipital CBF_p3: Gray matter cerebral blood flow at time point p3 in the occipital lobe




ACA-MCA CBF_p1: Cerebral blood flow in the borderzone of anterior cerebral artery and middle cerebral artery at time point p1




ACA-MCA CBF_p2: Cerebral blood flow in the borderzone of anterior cerebral artery and middle cerebral artery at time point p2




ACA-MCA CBF_p3: Cerebral blood flow in the borderzone of anterior cerebral artery and middle cerebral artery at time point p3




MCA-PCA CBF_p1: Cerebral blood flow in the borderzone of middle cerebral artery and posterior cerebral artery at time point p1




MCA-PCA CBF_p2: Cerebral blood flow in the borderzone of middle cerebral artery and posterior cerebral artery at time point p2




MCA-PCA CBF_p3: Cerebral blood flow in the borderzone of middle cerebral artery and posterior cerebral artery at time point p3




Cortical Tex_p1: Cortical exchange time at time point p1 as a measure of water transport across the endothelium




Cortical Tex_p2: Cortical exchange time at time point p2 as a measure of water transport across the endothelium




Cortical Tex_p3: Cortical exchange time at time point p3 as a measure of water transport across the endothelium




Frontal Tex_p1: Exchange time at time point p1 as a measure of water transport across the endothelium in the frontal lobe gray matter




Frontal Tex_p2: Exchange time at time point p2 as a measure of water transport across the endothelium in the frontal lobe gray matter




Frontal Tex_p3: Exchange time at time point p3 as a measure of water transport across the endothelium in the frontal lobe gray matter




Parietal Tex_p1: Exchange time at time point p1 as a measure of water transport across the endothelium in the parietal lobe gray matter




Parietal Tex_p2: Exchange time at time point p2 as a measure of water transport across the endothelium in the parietal lobe gray matter




Parietal Tex_p3: Exchange time at time point p3 as a measure of water transport across the endothelium in the parietal lobe gray matter




Temporal Tex_p1: Exchange time at time point p1 as a measure of water transport across the endothelium in the temporal lobe gray matter




Temporal Tex_p2: Exchange time at time point p2 as a measure of water transport across the endothelium in the temporal lobe gray matter




Temporal Tex_p3: Exchange time at time point p3 as a measure of water transport across the endothelium in the temporal lobe gray matter




Occipital Tex_p1: Exchange time at time point p1 as a measure of water transport across the endothelium in the occipital lobe gray matter




Occipital Tex_p2: Exchange time at time point p2 as a measure of water transport across the endothelium in the occipital lobe gray matter




Occipital Tex_p3: Exchange time at time point p3  as a measure of water transport across the endothelium in the occipital lobe gray matter




ACA-MCA Tex_p1: Exchange time at time point p1 as a measure of water transport across the endothelium in the anterior cerebral artery-middle cerebral artery borderzone




ACA-MCA Tex_p2: Exchange time at time point p2 as a measure of water transport across the endothelium in the anterior cerebral artery-middle cerebral artery borderzone




ACA-MCA Tex_p3: Exchange time at time point p3 as a measure of water transport across the endothelium in the anterior cerebral artery-middle cerebral artery borderzone




MCA-PCA Tex_p1: Exchange time at time point p1 as a measure of water transport across the endothelium in the middle cerebral artery-posterior cerebral artery borderzone




MCA-PCA Tex_p2: Exchange time at time point p2 as a measure of water transport across the endothelium in the middle cerebral artery-posterior cerebral artery borderzone




MCA-PCA Tex_p3: Exchange time at time point p3 as a measure of water transport across the endothelium in the middle cerebral artery-posterior cerebral artery borderzone




SE Frontal GM_p3: Signal enhancement at timepoint p3 compared to baseline timepoint p1 in the frontal lobe gray matter. Signal intensities were normalized by signal intensity of Vit. E 




SE Frontal WM_p3: Signal enhancement at timepoint p3 compared to baseline timepoint p1 in the frontal lobe white matter. Signal intensities were normalized by signal intensity of Vit. E




SE Parietal GM_p3: Signal enhancement at timepoint p3 compared to baseline timepoint p1 in the parietal lobe gray matter. Signal intensities were normalized by signal intensity of Vit. E




SE Parietal WM_p3: Signal enhancement at timepoint p3 compared to baseline timepoint p1 in the parietal lobe white matter. Signal intensities were normalized by signal intensity of Vit. E




SE Occipital GM_p3: Signal enhancement at timepoint p3 compared to baseline timepoint p1 in the occipital lobe gray matter. Signal intensities were normalized by signal intensity of Vit. E




SE Occipital WM_p3: Signal enhancement at timepoint p3 compared to baseline timepoint p1 in the occipital lobe white matter. Signal intensities were normalized by signal intensity of Vit. E




SE Temporal GM_p3: Signal enhancement at timepoint p3 compared to baseline timepoint p1 in the temporal lobe gray matter. Signal intensities were normalized by signal intensity of Vit. E




SE Temporal WM_p3: Signal enhancement at timepoint p3 compared to baseline timepoint p1 in the temporal lobe white matter. Signal intensities were normalized by signal intensity of Vit. E




SAS_p3: Signal enhancement at timepoint p3 compared to baseline timepoint p3 in the SAS. Signal intensities were normalized by signal intensity of Vit. E




Ventricles_p3: Signal enhancement at timepoint p3 compared to baseline timepoint p1 in the lateral ventricles. Signal intensities were normalized by signal intensity of Vit. E




ICA_p3: Signal enhancement at timepoint p3 compared to baseline timepoint p1 in the ICA. Signal intensities were normalized by signal intensity of Vit. E




SS_p3: Signal enhancement at timepoint p3 compared to baseline timepoint p1 in the SS.. Signal intensities were normalized by signal intensity of Vit. E




CSS_p3: Signal enhancement at timepoint p3 compared to baseline timepoint p1 in the confluence of sinuses. Signal intensities were normalized by signal intensity of Vit. E




Hippocampus_p3: Signal enhancement at timepoint p3 compared to baseline timepoint p1 in the hippocamppus. Signal intensities were normalized by signal intensity of Vit. E




CBV Frontal GM_p2: Cerebral blood volume in the frontal lobe gray matter at timepoint p2




CBV Frontal WM_p2:Cerebral blood volume in the frontal lobe white matter at timepoint p2




CBV Parietal GM_p2: Cerebral blood volume in the parietal lobe gray matter at timepoint p2




CBV Parietal WM_p2: Cerebral blood volume in the parietal lobe white matter at timepoint p2




CBV Occipital GM_p2: Cerebral blood volume in the occipital  lobe gray matter at timepoint p2




CBV Occipital WM_p2: Cerebral blood volume in the occipital lobe white matter at timepoint p2




CBV Temporal GM_p2: Cerebral blood volume in the temporal lobe gray matter at timepoint p2




CBV Temporal WM_p2: Cerebral blood volume in the temporal lobe white matter at timepoint p




CSS/ICA_p2: Ratio of signal intensity in the confluence of sinuses to that in the internal carotid artery




Vit E (Pre)_p1: Raw signal intensity in the Vit E capsule at time point p1, precontrast




Vit E (Pre)_p2: Raw signal intensity in the Vit E capsule at time point p2, precontrast




Vit E (Post)_p2: Raw signal intensity in the Vit E capsule at time point p2, postcontrast




Vit E (post)_p3: Raw signal intensity in the Vit E capsule at time point p3, postcontrast




Frontal GM (Pre)_p1: Raw signal intensity in the frontal gray matter at time point p1, precontrast




Frontal GM (Pre)_p2: Raw signal intensity in the frontal gray matter at time point p2, precontrast




Frontal GM (Post)_p2: Raw signal intensity in the frontal gray matter at time point p2, postcontrast




Frontal GM (post)_p3: Raw signal intensity in the frontal gray matter at time point p1, postcontrast




Parietal GM (Pre)_p1: Raw signal intensity in the parietal  gray matter at time point p1, precontrast




Parietal GM (Pre)_p2: Raw signal intensity in the parietal gray matter at time point p2, precontrast




Parietal GM (Post)_p2: Raw signal intensity in the parietal gray matter at time point p2, postcontrast




Parietal GM (post)_p3: Raw signal intensity in the parietal gray matter at time point p3, postcontrast




Occipital GM (Pre)_p1: Raw signal intensity in the occipital gray matter at time point p1, precontrast




Occipital GM (Pre)_p2: Raw signal intensity in the occipital gray matter at time point p2, precontrast




Occipital GM (Post)_p2: Raw signal intensity in the occipital gray matter at time point p2, postcontrast




Occipital GM (post)_p3: Raw signal intensity in the occipital gray matter at time point p3, postcontrast




Temporal GM (Pre)_p1: Raw signal intensity in the temporal gray matter at time point p1, precontrast




Temporal GM (Pre)_p2: Raw signal intensity in the temporal gray matter at time point p2, precontrast




Temporal GM (Post)_p2: Raw signal intensity in the temporal gray matter at time point p2, postcontrast




Temporal GM (post)_p3: Raw signal intensity in the temporal gray matter at time point p3, postcontrast




Frontal WM (Pre)_p1: Raw signal intensity in the frontal white matter at time point p1, precontrast




Frontal WM (Pre)_p2: Raw signal intensity in the frontal white matter at time point p2, precontrast




Frontal WM (Post)_p2: Raw signal intensity in the frontal white matter at time point p2, postcontrast




Frontal WM (post)_p3: Raw signal intensity in the frontal white matter at time point p3, postcontrast




Parietal WM (Pre)_p1: Raw signal intensity in the parietal white matter at time point p1, precontrast




Parietal WM (Pre)_p2: Raw signal intensity in the parietal white matter at time point p2, precontrast




Parietal WM (Post)_p2: Raw signal intensity in the parietal white matter at time point p2, postcontrast




Parietal WM (post)_p3: Raw signal intensity in the parietal white matter at time point p3, postcontrast




Occipital WM (Pre)_p1: Raw signal intensity in the occipital white matter at time point p1, precontrast




Occipital WM (Pre)_p2: Raw signal intensity in the occipital white matter at time point p2, precontrast




Occipital WM (Post)_p2: Raw signal intensity in the occipital white matter at time point p2, postcontrast




Occipital WM (post)_p3: Raw signal intensity in the occipital white matter at time point p3, postcontrast




Temporal WM (Pre)_p1: Raw signal intensity in the temporal white matter at time point p1, precontrast




Temporal WM (Pre)_p2: Raw signal intensity in the temporal white matter at time point p2, precontrast




Temporal WM (Post)_p2: Raw signal intensity in the temporal white matter at time point p2, postcontrast




Temporal WM (post)_p3: Raw signal intensity in the temporal white matter at time point p3, postcontrast




SAS (Pre)_p1: Raw signal intensity in the SAS at time point p1, precontrast




SAS (Pre)_p2: Raw signal intensity in the SAS at time point p2, precontrast




SAS (Post)_p2: Raw signal intensity in the SAS at time point p2, postcontrast




SAS (post)_p3: Raw signal intensity in the SAS at time point p3, postcontrast




Ventricles (Pre)_p1: Raw signal intensity in the ventricles at time point p1, precontrast




Ventricles (Pre)_p2: Raw signal intensity in the ventricles at time point p2, precontrast




Ventricles (Post)_p2: Raw signal intensity in the ventricles at time point p2, postcontrast




Ventricles (post)_p3: Raw signal intensity in the ventricles at time point p3, postcontrast




ICA (Pre)_p1: Raw signal intensity in the internal carotid artery at time point p1, precontrast




ICA (Pre)_p2: Raw signal intensity in the internal carotid artery at time point p2, precontrast




ICA (Post)_p2: Raw signal intensity in the internal carotid artery at time point p2, postcontrast




ICA (post)_p3: Raw signal intensity in the internal carotid artery at time point p3, postcontrast




SS (Pre)_p1: Raw signal intensity in the sagittal sinus at time point p1, precontrast




SS (Pre)_p2: Raw signal intensity in the sagittal sinus at time point p2, precontrast




SS (Post)_p2: Raw signal intensity in the sagittal sinus at time point p2, postcontrast




SS (post)_p3: Raw signal intensity in the sagittal sinus at time point p3, postcontrast




CSS (Pre)_p1: Raw signal intensity in the confluence of sinuses at time point p1, precontrast




CSS (Pre)_p2: Raw signal intensity in the confluence of sinuses at time point p2, precontrast




CSS (Post)_p2: Raw signal intensity in the confluence of sinuses at time point p2, postcontrast




CSS (post)_p3: Raw signal intensity in the confluence of sinuses at time point p3, postcontrast




Hippocampus (Pre)_p1: Raw signal intensity in the hippocampus at time point p1, precontrast




Hippocampus (Pre)_p2: Raw signal intensity in the hippocampus at time point p2, precontrast




Hippocampus (Post)_p2: Raw signal intensity in the hippocampus at time point p2, postcontrast




Hippocampus (post)_p3: Raw signal intensity in the hippocampus at time point p3, postcontrast