cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.17632/m8rxcszxh4.1
title: Immunomodulatory_Roles_of_Statin/Ezetimibe

description: [Title of corresponding article]
Distinct Effects of Rosuvastatin and Rosuvastatin/Ezetimibe on Senescence Markers of CD8+ T cells in Patients with Type 2 Diabetes Mellitus: A Randomized Controlled Trial

[Author list]
Sang-Hyeon Ju1†, Thi Linh Nguyen2†, Joung Youl Lim1, Minchul Song1, Ji Min Kim3,4, Yea Eun Kang1,4, Hyon-Seung Yi1,2,4, Kyong Hye Joung3,4, Ju Hee Lee1,4, Hyun Jin Kim1,4, Bon Jeong Ku1,4*
1Division of Endocrinology and Metabolism, Department of Internal Medicine, Chungnam National University Hospital, Daejeon, Republic of Korea 
2Department of Medical Science, Chungnam National University School of Medicine, Daejeon, Republic of Korea
3Division of Endocrinology and Metabolism, Department of Internal Medicine, Chungnam National University Sejong Hospital, Sejong, Republic of Korea
4Department of Internal Medicine, Chungnam National University School of Medicine, Daejeon, Republic of Korea.
†; equal contribution for co-first author
*; corresponding author

[Abstract]
Objectives
Chronic low-grade inflammation has been widely recognized as a pathophysiological defect contributing to β-cell failure in type 2 diabetes mellitus (T2DM). Statin therapy is known to ameliorate CD8+ T cell senescence, a mediator of chronic inflammation. Additional immunomodulatory roles of ezetimibe are not fully understood. Therefore, we investigated the effect of statin or statin/ezetimibe combination treatment on T cell senescence markers.
Methods
In this two-group parallel and randomized controlled trial, we enrolled 149 patients with T2DM whose low-density lipoprotein cholesterol (LDL-C) was 100 mg/dL or higher. Patients were randomly assigned into rosuvastatin (N=74) or rosuvastatin/ezetimibe group (N=75). Immunophenotype of peripheral blood mononuclear cells and metabolic profiles were analyzed using samples of baseline and post-12 weeks of medication.
Results
Fractions of CD8+CD57+ (senescent CD8+ T cells) and CD4+FoxP3+ (Tregs) significantly decreased after intervention in the rosuvastatin/ezetimibe group (−4.5 ± 14.1 and −1.2 ± 2.3 %, respectively), while these fractions showed minimal change in the rosuvastatin group (2.8 ± 9.4 and 1.4 ± 1.5 %, respectively). The degree of LDL-C reduction was correlated with an improvement in HbA1c (R=0.193, p=0.021). Changes in the CD8+CD57+ fraction positively correlated with patient age (R=0.538, p=0.026). Notably, fraction change in senescent CD8+ T cells showed no significant relationship with changes in either HbA1c (p=0.314) or LDL-C (p=0.592). Finally, the ratio of naïve to memory CD8+ T cells increased in the rosuvastatin/ezetimibe group (p=0.011), but not in the rosuvastatin group (p=0.339).
Conclusions
We observed a reduction in senescent CD8+ T cells and an increase in the ratio of naive to memory CD8+ T cells by rosuvastatin/ezetimibe treatment. Our results demonstrate the immunomodulatory roles of ezetimibe in combination with statins, which are independent of improvements in lipid or HbA1c levels.
DOI: 10.17632/twygbbvyj4.1
title: Estimation of human spine orientation with inertial measurement units (IMU) at low sampling rate: How low can we go?

description: Dataset for the scientific paper

Estimation of human spine orientation with inertial measurement units (IMU) at low sampling rate: How low can we go?
Ryan Riddick, Esther Smits, Gert Faber, Cory Shearwin, Paul Hodges, and Wolbert van den Hoorn


The main dataset file is in "validation2021_dataset.mat", which is Matlab's compressed binary format.

Raw data files for each participant are stored in the folders "s1", "s2", ..., "s12". Optimized filter parameters are stored in the "filterParameters" folder. Figures and tables for the paper are stored in the "figureAndTables" folder.

See paper and the code repository ReadMe in the related link for more information about how the data was created, structured, and analyzed.
DOI: 10.17632/jfwfwnfkns.1
title: Rate-dependent adhesion in combination with the synergetic action of limbs facilitates grasshoppers’ reliable attachment under extreme conditions

description: The data shows the maximum force s and corresponding pulling speeds when grasshoppers were challenged with slow and extremely fast pulling.
DOI: 10.17632/73t47wpbw2.1
title: Climatic variables and milk productivity

description: The maximum & minimum temperature, dry bulb & wet bulb temperature (°C), and relative humidity (%) were recorded twice daily at 07.22 hours and 14.22 hours as per (Indian Meteorological Department) IMD protocol. Maximum and minimum average mean ± SD values of all-weather parameters/variables for the months of March, April and May during last three consecutive years (2021, 2022 and 2023).
The daily milk yield data was recorded (Kg/day/animal) in morning and evening for buffalo and thrice daily (morning, noon and evening) for Karan Fries cows.
DOI: 10.17632/sm3cwvnsxb.1
title: Engineering functional materials through bacteria-assisted living grafting

description: The source data for the paper "Engineering functional materials through bacteria-assisted living grafting."
DOI: 10.17632/dnwvysg4rc.1
title: Worm gear and worm gear vibration data

description: Worm gear and worm gear vibration data
DOI: 10.17632/jwmd6z8trf.1
title: The dopamine neuron synaptic map in the striatum. Chuhma et al.

description: Raw data and a Python script for PSC size prediction in Chuhma et al. 
'Raw data PSC mapping' folder has raw data (csv files) for Fig 3, which were also used for prediction of PSC sizes (Fig 4 and Python script). The folder also has a csv file with 3D locations of the 150 µm cubic grid lattice (grid_150um.csv). All other raw data sets are in 'raw_data (NC).xlsx'; each sheet has a single data set.
'GluF_ChI_pred.py' is a Python source code for PSC prediction with deep learning using PSC recording raw data for training. This script shows one example for the iGluR response in ChIs (Glu_fast_ChI.csv) as a training data set. By using different training data sets with the same model, different receptor/cell type prediction maps will be obtained.
'PSC size predictions' folder has results of prediction, with 100 repetitions for each receptor/cell type, as csv files, which were used for this paper.
DOI: 10.17632/c3r9chw9rb.1
title: Comprehensive single-cell genome analysis at nucleotide resolution using the PTA Analysis Toolbox

description: We developed a comprehensive bioinformatic workflow, called the PTA Analysis Toolbox (PTATO), to accurately detect single base substitutions, insertions-deletions (indels) and structural variants in PTA-based WGS data. PTATO includes a machine learning approach and filtering based on recurrency to distinguish PTA-artefacts from true mutations with high sensitivity (up to 90%), outperforming existing bioinformatic approaches. Our results show that PTATO enables studying somatic mutagenesis in the genomes of single cells with unprecedented sensitivity and accuracy.
DOI: 10.17632/rgtz2gm7vv.1
title: RPvdsEx Code for Protocol for playback of phantom echoes from approaching objects to scanning bats

description: Because bats emit ultrasound and listen to echoes to perceive their surroundings, presenting phantom echoes is useful for understanding their perception of echolocation. Here, we describe a protocol for the real-time playback of phantom echoes, especially from approaching objects. This acoustic presentation of virtual objects using a microphone, digital signal processor, and loudspeaker successfully induced the escape behavior of bats, which resembled a natural response to approaching objects, and allowed us to clarify their detection algorithm for approaching objects.
DOI: 10.17632/22xwh6ptk2.2
title: Data for:Improved Population Mapping for China Using the 3D Build-ing, Nighttime Light, Points-of-interest, and Land Use/Cover Data Within a Multiscale Geographically Weighted Regression Model

description: Auxiliary Data.gdb:
Land_use: original land use data
POI_name: interests-point-data from the Amap platform (name indicates category)

New_gridded_population_dataset(.gdb): experimental result data, i.e., a gridded population map of mainland China with a resolution of 100 meters

New_minus_WorldPop_PopulationResidual(.gdb): pixel-level residuals of the new gridded population dataset with the Worldpop dataset

PopulationData_AdministrativeUnitLevel.gdb:
Population_data_mainlandChina_level3: population data at the district and county level in mainland China
Population_data_Name_level4_Table: township and street-level population data for provinces and municipalities

POI_Correlation_Coefficient:
Python script: programming implementation for selecting the optimal bandwidth for POI
Zonal statistical output of POI kernel density values: summary of various POI kernel densities in residential areas of administrative units
Summary of POI Pearson correlation coefficients: sum of Pearson's correlation coefficients for 13 types of POIs at a certain bandwidth

Note: 
Due to the storage space limitation, 3D building, nighttime light, and WorldPop datasets have not been uploaded. To access these publicly available data, please visit the official website via the "Related links" at the bottom. In addition, we are not authorized to share data for the fourth level of administrative boundaries, so we only share the corresponding population data in tabular form.
DOI: 10.17632/zjb5ynz5n4.1
title: Data for "Risk assessment during nest defense against three simulated predators by northern house wrens (Troglodytes aedon aedon)"

description: Offspring predation is one of the greatest obstacles to an organism’s reproductive success, but parents vary in the strength of their response to potential predators. One explanation for this variable investment is that defending current offspring has the potential to lower future reproductive success if the predator is also capable of injuring or killing the parent. House wrens (Troglodytes aedon aedon) are cavity-nesting songbirds that defend against multiple species of nest predators including small mammals, birds of prey, and snakes. Here, we used three different predator decoys: two nest predators - an eastern chipmunk (Tamias striatus) and an eastern ratsnake (Pantherophis alleghaniensis) - as well as a predator of both offspring and adults - a juvenile Cooper’s hawk (Accipiter cooperi) - to elicit nest defense and test whether females use risk assessment to modulate their antipredator behavior. We found that antipredator behaviors were not significantly different between the two nest predators, which posed a high risk to the nestlings, but lower risk to the parents as neither species frequently captures adult wrens. Females also did not differ significantly in their responses to the snake between years, suggesting that the population-level response might be consistent through time despite substantial individual variation among females. However, female wrens never dove at or attacked the Cooper’s hawk while they frequently attacked both the snake and chipmunk decoys. Neighboring house wrens from adjacent territories were also less likely to respond to the hawk, but more heterospecifics mobbed the hawk than the snake decoy. Collectively, these results show that risk assessment and the strength of the antipredator response varies substantially both within and among species. Female house wrens exhibit plasticity in their nest defense behavior, and they respond to different types of predators in a way that could maximize lifetime fitness while risking the loss of their current offspring. 

Please see our BioRxiv Preprint (and eventual publication) for more information on the specific details of our protocol and statistical analysis.
DOI: 10.17632/zjb5ynz5n4.3
title: Data for "Risk assessment during nest defense against three simulated predators by northern house wrens (Troglodytes aedon aedon)"

description: Offspring predation is one of the greatest obstacles to an organism’s reproductive success, but parents vary in the strength of their response to potential predators. One explanation for this variable investment is that defending current offspring has the potential to lower future reproductive success if the predator is also capable of injuring or killing the parent. House wrens (Troglodytes aedon aedon) are cavity-nesting songbirds that defend against multiple species of nest predators including small mammals, birds of prey, and snakes. Here, we used three different predator decoys: two nest predators - an eastern chipmunk (Tamias striatus) and an eastern ratsnake (Pantherophis alleghaniensis) - as well as a predator of both offspring and adults - a juvenile Cooper’s hawk (Accipiter cooperi) - to elicit nest defense and test whether females use risk assessment to modulate their antipredator behavior. We found that antipredator behaviors were not significantly different between the two nest predators, which posed a high risk to the nestlings, but lower risk to the parents as neither species frequently captures adult wrens. Females also did not differ significantly in their responses to the snake between years, suggesting that the population-level response might be consistent through time despite substantial individual variation among females. However, female wrens never dove at or attacked the Cooper’s hawk while they frequently attacked both the snake and chipmunk decoys. Neighboring house wrens from adjacent territories were also less likely to respond to the hawk, but more heterospecifics mobbed the hawk than the snake decoy. Collectively, these results show that risk assessment and the strength of the antipredator response varies substantially both within and among species. Female house wrens exhibit plasticity in their nest defense behavior, and they respond to different types of predators in a way that could maximize lifetime fitness while risking the loss of their current offspring. 

Please see our BioRxiv Preprint (and eventual publication) for more information on the specific details of our protocol and statistical analysis.

Note: version 3 now includes an updated R Markdown file (v2) with the revised code that we used to conduct our statistical analyses and create our figures.
DOI: 10.17632/zjb5ynz5n4.4
title: Data for "Risk assessment during nest defense against three simulated predators by northern house wrens (Troglodytes aedon aedon)"

description: Offspring predation is one of the greatest obstacles to an organism’s reproductive success, but parents vary in the strength of their response to potential predators. One explanation for this variable investment is that defending current offspring has the potential to lower future reproductive success if the predator is also capable of injuring or killing the parent. House wrens (Troglodytes aedon aedon) are cavity-nesting songbirds that defend against multiple species of nest predators including small mammals, birds of prey, and snakes. Here, we used three different predator decoys: two nest predators - an eastern chipmunk (Tamias striatus) and an eastern ratsnake (Pantherophis alleghaniensis) - as well as a predator of both offspring and adults - a juvenile Cooper’s hawk (Accipiter cooperi) - to elicit nest defense and test whether females use risk assessment to modulate their antipredator behavior. We found that antipredator behaviors were not significantly different between the two nest predators, which posed a high risk to the nestlings, but lower risk to the parents as neither species frequently captures adult wrens. Females also did not differ significantly in their responses to the snake between years, suggesting that the population-level response might be consistent through time despite substantial individual variation among females. However, female wrens never dove at or attacked the Cooper’s hawk while they frequently attacked both the snake and chipmunk decoys. Neighboring house wrens from adjacent territories were also less likely to respond to the hawk, but more heterospecifics mobbed the hawk than the snake decoy. Collectively, these results show that risk assessment and the strength of the antipredator response varies substantially both within and among species. Female house wrens exhibit plasticity in their nest defense behavior, and they respond to different types of predators in a way that could maximize lifetime fitness while risking the loss of their current offspring. 

Please see our BioRxiv Preprint (and eventual publication) for more information on the specific details of our protocol and statistical analysis.

Note: version 3 now includes an updated R Markdown file (v3) with the revised code that we used to conduct our statistical analyses and create our figures.
DOI: 10.17632/zjb5ynz5n4.2
title: Data for "Risk assessment during nest defense against three simulated predators by northern house wrens (Troglodytes aedon aedon)"

description: Offspring predation is one of the greatest obstacles to an organism’s reproductive success, but parents vary in the strength of their response to potential predators. One explanation for this variable investment is that defending current offspring has the potential to lower future reproductive success if the predator is also capable of injuring or killing the parent. House wrens (Troglodytes aedon aedon) are cavity-nesting songbirds that defend against multiple species of nest predators including small mammals, birds of prey, and snakes. Here, we used three different predator decoys: two nest predators - an eastern chipmunk (Tamias striatus) and an eastern ratsnake (Pantherophis alleghaniensis) - as well as a predator of both offspring and adults - a juvenile Cooper’s hawk (Accipiter cooperi) - to elicit nest defense and test whether females use risk assessment to modulate their antipredator behavior. We found that antipredator behaviors were not significantly different between the two nest predators, which posed a high risk to the nestlings, but lower risk to the parents as neither species frequently captures adult wrens. Females also did not differ significantly in their responses to the snake between years, suggesting that the population-level response might be consistent through time despite substantial individual variation among females. However, female wrens never dove at or attacked the Cooper’s hawk while they frequently attacked both the snake and chipmunk decoys. Neighboring house wrens from adjacent territories were also less likely to respond to the hawk, but more heterospecifics mobbed the hawk than the snake decoy. Collectively, these results show that risk assessment and the strength of the antipredator response varies substantially both within and among species. Female house wrens exhibit plasticity in their nest defense behavior, and they respond to different types of predators in a way that could maximize lifetime fitness while risking the loss of their current offspring. 

Please see our BioRxiv Preprint (and eventual publication) for more information on the specific details of our protocol and statistical analysis.

Note: version 2 now includes an R Markdown file with all of the code that we used to conduct our statistical analyses and create our figures.
DOI: 10.17632/wg4dmwddjy.1
title: 3D composite architectures manufactured via AFP for improved delamination resistance - Repeated Segment Stacking

description: Composite laminates are vulnerable to delamination failure between the plies. With the increased usage of Automated Fibre Placement (AFP) to manufacture composites it is important to develop delamination mitigation strategies which are compatible with AFP manufacture. In this work we highlight the strategy of segmenting plies and stacking segment-by-segment via AFP, rather than ply-by-ply, to provide interlocks which resist delamination. We develop a novel category of segmented ply laminates, `Repeated Segment Stacking (RSS)’, to create significant through-thickness fibre reinforcements throughout the laminate thickness with AFP. We demonstrate successful AFP prototyping of the RSS mesostructures, including the ability to control the fibre undulation geometry. Our results show that low amplitude designs provide reinforcement across all horizontal planes whilst not significantly compromising in-plane performance, whilst increased amplitude designs mimic the impact resistant Herringbone structure of the Mantis shrimp’s dactyl club. Experimental testing to HVI, LVI, and CAI reveals the RSS designs reduce the delamination footprint and can contain damage at undulation boundaries. This first investigation of these original concepts demonstrates that the proposed RSS concept provides a promising development route for AFP-manufactured delamination resistant CFRP structures.

This repository contains raw data from the HVI, LVI & CAI tests and c-scan data post impact.
DOI: 10.17632/rfcgc5f2d9.1
title: LINF_210010500

description: protein of unknown function - conserved; Leishmania infantum (strain JPCM5)
DOI: 10.17632/fhymr9m9tc.1
title: LINF_210010300

description: DnaJ domain-containing protein | JDP3 | J3; Leishmania infantum (strain JPCM5)
DOI: 10.17632/pcwnxc2tpj.1
title: LINF_210009100

description: Rtr1/RPAP2 domain-containing protein; Leishmania infantum (strain JPCM5)
DOI: 10.17632/6rfnsxsn8h.1
title: Nature-based vs indoor calisthenics on performance and well-being (affect)

description: The present data stems from a trial where two groups of participants exercised a 12-exercise calisthenics routine in a nature-based environment (group A) and indoors (group B). The aim was to test how exercising the same routine in different environments would affect well-being and cognitive measures, performance, and movement adaptability measured by body segment accelerations. 

Data sets 1 and 2 include all of the outcomes and process measures, for use in SPSS.

DFA code is a python file and includes code from fathon - a python package for detrended fluctuation analysis (DFA) and related algorithms. Find it at https://pypi.org/project/fathon/

SampEn code is a python file with the code for sample entropy
DOI: 10.17632/vrtgv9wyc6.1
title: Raw waveform microtremor data recorded in the City of Meulaboh

description: The microtremor data herein was collected using two seismometers set at a close distance. The first seismometer is a surface-type Geobit S100 seismometer (ST Geobit S100). The second one is a low-cost Raspberry Shake 3D (RS-3D) seismometer.
DOI: 10.17632/vrtgv9wyc6.2
title: Raw waveform microtremor data recorded in the City of Meulaboh

description: The microtremor data herein was collected using two seismometers set at a close distance. The first seismometer is a surface-type Geobit S100 seismometer (ST Geobit S100). The second one is a low-cost Raspberry Shake 3D (RS-3D) seismometer.
DOI: 10.17632/vrtgv9wyc6.3
title: Raw waveform microtremor data recorded in the City of Meulaboh

description: The microtremor data herein was collected using two seismometers set at a close distance. The first seismometer is a surface-type Geobit S100 seismometer (ST Geobit S100). The second one is a low-cost Raspberry Shake 3D (RS-3D) seismometer.