cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.27753000
title: Supplementary Material for: Phase I clinical study of a multi-kinase inhibitor TG02 capsule for the treatment of recurrent high-grade gliomas with failed temozolomide treatment in Chinese patients

description: Introduction: Here, we report the safety, tolerability, pharmacokinetic characteristics and preliminary efficacy of a multi-kinase inhibitor (TG02 capsule) as a new therapy for patients with recurrent high-grade gliomas in China.
Methods: This is a single-center, dose-escalation, open-label phase I study, which enrolled patients with recurrent high-grade gliomas who failed to temozolomide. Patients were assigned sequentially into different dose groups and received TG02 every 4 weeks. The dose was increased in a traditional 3+3 design. Primary endpoints were the dose-limited toxicity (DLT) and the maximum tolerated dose (MTD).
Results: Twelve patients (8 glioblastomas, 4 diffuse astrocytoma) were enrolled between May 2019 and November 2021. Three patients received 100 mg and 9 received 150 mg TG02 twice a week. The plasma concentration of TG02 reached the maximum at 2 hours after administration, and the elimination half-life was about 7 hours. No DLT occurred and MTD was not defined in this study. Eleven patients had one or more investigator-assessed treatment-related adverse events (TRAEs). The most frequent TRAEs were vomiting (91.7%) and diarrhea (75.0%), and 50% of the patients had grade 3 or 4 adverse events. There were no treatment-related deaths. The median progression-free survival and overall survival were 1.77 (95% confidence interval [CI]: 0.82-4.24) and 9.63 (95%CI: 2.66-not estimated) months, respectively.
Conclusions: TG02 capsule 150mg twice a week is safe and tolerable in Chinese patients with recurrent high-grade gliomas. Patients who failed to temozolomide showed obvious tumor reduction when switching to TG02 capsule. The efficacy for recurrent gliomas warrant further investigation.
DOI: 10.6084/m9.figshare.27861519
title: Supplementary Material for: RIP3 augments neuroinflammation by facilitating neutrophil infiltration during an ischemic stroke.

description: Introduction: Neutrophil infiltration is responsible for the neuroinflammation during an ischemic stroke. Here, we explored the role of receptor-interacting protein kinase 3 (RIP3) in neutrophil infiltration during an ischemic stroke.
Methods: The rat middle cerebral artery occlusion (MCAO) model was utilized to identify pivotal proteins involved in neutrophil infiltration during an ischemic stroke. Neutrophils were isolated from the peripheral blood of mice, and a co-immunoprecipitation (co-IP) assay was performed to identify the proteins that interact with RIP3.
Results: The rat MCAO model was successfully established. Myeloperoxidase (MPO) was significantly up-regulated in the MCAO group, indicating the presence of neutrophil infiltration. RIP3 protein level exhibited a similar trend to MPO protein level, suggesting that neuroinflammation might be partly activated by RIP3 through the promotion of neutrophil infiltration. Co-immunoprecipitation (co-IP) and mass spectrometry (MS) analyses suggested that RIP3 facilitated neutrophil infiltration partly by affecting protein kinases (Rock1 and Prkaca) downstream of RIP3, and the interaction between RIP3 and Rock1 or Prkaca was validated by IF and co-IP assays.
Conclusion: In this study, it was observed that RIP3 affects neutrophil infiltration, a critical phenomenon associated with neuronal injury during ischemic stroke, partly by the modulation of downstream proteins such as Rock1 and Prkaca.
DOI: 10.6084/m9.figshare.27861669
title: Supplementary Material for: Exosomal LncRNA and CircRNA Regulate Peripheral Blood Mononuclear Cell Function through a Competitive Endogenous RNA Mechanism in Allergic Rhinitis

description: Introduction: Peripheral blood mononuclear cells (PBMCs) dysfunction is involved in the pathogenesis and progression of allergic rhinitis (AR). This study aims to investigate the competing endogenous RNA (ceRNA) networks in PBMCs influenced by differentially expressed long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) found in plasma exosomes induced by AR.
Methods: All subjects were from the Affiliated Taizhou People's Hospital of Nanjing Medical University. Differential expression of mRNAs in PBMCs and lncRNAs/circRNAs in plasma exosomes was analyzed using high-throughput sequencing. Differentially expressed lncRNAs and circRNAs that target mRNAs were identified using bioinformatics methods. The predicted target mRNAs were intersected with the differentially expressed mRNAs in PBMCs to construct ceRNA networks. The subcellular localizations of lncRNAs and circRNAs within the ceRNA networks were determined using RNA fluorescence in situ hybridization or bioinformatics methods. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses of differentially expressed mRNAs in PBMCs were conducted using the clusterProfiler R package. Quantitative reverse transcription polymerase chain reaction (qRT-PCR) was used to validate the expression levels of each molecule within the constructed ceRNA networks in clinical samples, along with receiver operating characteristic (ROC) curve analysis to assess diagnostic value. Further validation was performed using in vitro cultured PBMCs and dual-luciferase reporter assays.
Results: Five differentially expressed circRNAs and 31 differentially expressed lncRNAs were identified in exosomes. In PBMCs, 130 differentially expressed mRNAs were identified. Six ceRNA networks were constructed, affecting PBMCs chemorepellent activity, JAK-STAT signaling pathway, and other functions or pathways. The expression level of ENST00000650850 in plasma exosomes was significantly lower in AR patients, suggesting its potential diagnostic value. The expression level of ENST00000650850 in plasma exosomes was positively correlated with the expression levels of ENST00000650850 and IL6 mRNA in PBMCs. PBMCs from healthy individuals were stimulated with plasma exosomes isolated from AR patients, leading to a reduction in IL6R mRNA expression levels in the PBMCs.
Conclusion: Differentially expressed lncRNA (ENST00000650850) in plasma-derived exosomes of AR patients may regulate IL6R mRNA expression in PBMCs via miR-6747-3p, thereby influencing PBMC function and contributing to the pathogenesis and progression of AR.
DOI: 10.15468/dl.urgn8v
title: Occurrence Download

description: A dataset containing 15 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is Peru",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 "TaxonKey is Galictis vittata (Schreber, 1776)"
 ]
}

 The dataset includes 15 records from 7 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0048883-240506114902167/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.17632/djhjjcvwz5.2
title: The Lower and Middle Miocene lithostratigraphy of the northern Vienna Basin (Slovakia) – supporting data

description: The dataset includes a single text file with a detailed description of all lithostratigraphic units for the Lower and Middle Miocene stratigraphic intervals, which were redefined in the accompanied manuscript, following the International Stratigraphic Guide. The information included in the file was gained trough a review of publications and manuscripts with the focus on geological mapping, petroleum, hydrogeological or geothermal prospection, or general basin analysis, stratigraphic, paleontological and geochronological research. This data file is a supplementary material for the accompanied manuscript, submitted in the Geological Society of London Special Publication entitled "The Miocene Extensional Pannonian Superbasin, Volume 1: Regional Geology" with the title of the contribution "Kováč et al.: The Miocene to Quaternary evolution of the Vienna Basin northeastern part: Geodynamics, eustasy, stratigraphy and depositional systems".
DOI: 10.18739/a2rn3078p
title: Beaufort Sea zooplankton, 1951 - 1975

description: The zooplankton collections reported were obtained by the Arctic Biological Station during the years 1941, 1961,1962,1971 and 1973 to 1975 in the Beaufort Sea. Collections were made using nets of various meshes and of various sizes. Hauls were made mainly vertically, but occasionally horizontally or obliquely in depths from 2 to 700 meters. Number of organisms from these are given per cubic metres of water sampled assuming full efficiency . This data was rescued from the technical report. Grainger, E. H. and C. Grohe, 1975. Zooplankton Data from the Beaufort Sea. Fisheries Marine Service Technical Report No 591
DOI: 10.24381/cds.7c27fd20
title: CERRA sub-daily regional reanalysis data for Europe on model levels from 1984 to present
DOI: 10.24381/cds.a7f3cd0b
title: CERRA-Land sub-daily regional reanalysis data for Europe from 1984 to present
DOI: 10.34740/kaggle/dsv/816507
title: Random numbers
DOI: 10.48324/dandi.000292/0.220708.1652
title: UHN whole-cell patch-clamp excitability recordings from mouse cortical neurons

description: Whole-cell patch clamp recordings from acute mouse brain slices of layer 5 cortex.
DOI: 10.5281/zenodo.11658845
title: Mean Relative Amplitude (MRA) dataset in MSTIDs study over China

description: Considering the temporal (10-60 minutes) and spatial scale (50-500 km) of MSTIDs, we initially perform grid partitioning of the detrending TEC data using a spatial grid resolution of 1° × 1° and a time resolution of 15 minutes. Based on similar principles, the mean relative amplitude (MRA) is calculated within each grid to represent the short-term averaged activity intensity of periodic disturbances.

The MRA dataset use the hdf5 data format and stores data on a monthly basis.(from Jan, 2014 to Aug, 2017).

The data variables includes year, day, hour, second, lat (IPP), lon(IPP), and MRA.

keyword: ionosphere, medium scale traveling ionospheic disturbances
DOI: 10.5281/zenodo.13838158
title: Psychological well-being of travellers on long-distance shipping voyages: A systematic review protocol
DOI: 10.6084/m9.figshare.27288708
title: Supplementary Material for: Diurnal profiles of the endocrine stress response in internet gaming disorder

description: Background: Differences in subjective stress perception and acute response of the hypothalamic-pituitary-adrenal (HPA) axis have been reported in internet gaming disorder (IGD). The present study aimed to further investigate alterations in diurnal profiles of the endocrine stress response system in IGD compared to healthy controls (HC). 

Methods: The diurnal course of endocrine markers (salivary cortisol and α-amylase) was investigated in a clinical sample of n = 29 adolescents with IGD compared to n = 26 HC. Further, the effect of unrestricted gaming versus restricted gaming was examined within the IGD group.

Results: No significant differences in salivary cortisol and α-amylase were observed comparing adolescents with IGD and HC. In addition, in the IGD group, there were no significant differences in salivary cortisol and α-amylase between conditions of unrestricted gaming versus restricted gaming. Compared to the HC group, the IGD group showed a significantly higher body mass index (BMI).

Conclusions: Our results indicate no alteration in diurnal profiles of the endocrine stress response in IGD.
DOI: 10.6084/m9.figshare.27860532
title: Supplementary Material for: Effects of childhood trauma and anxiety on the hypothalamic-pituitary-adrenal axis in chronic subjective tinnitus with distress

description: Introduction: There is some evidence for hypothalamic-pituitary-adrenal (HPA) axis hypofunction in chronic tinnitus, but findings are contradicting possibly due to clinical heterogeneity. This study aims to assess differential effects of childhood trauma and anxiety on HPA-axis functioning in adults suffering from chronic subjective tinnitus with distress. 
Methods: Salivary cortisol data were collected in 22 chronic subjective tinnitus sufferers (without major depression) and 29 healthy controls after awakening, at baseline and after a low-dose (0.5 mg) dexamethasone challenge. A factorial ANCOVA was conducted to compare the main effects of group (tinnitus versus controls), trauma and their interaction effect on the cortisol awakening response (CAR). Linear mixed models were fitted for baseline and post-dexamethasone cortisol levels with group, sampling time, trauma and their interactions as fixed factors and subject as the random effect. The Beck Anxiety Index, Anxiety Sensitivity Index and Panic Disorder Severity Scale were included to investigate effects of anxiety.
Results: A significant interaction between group and trauma (F(1, 47) = 6.9755, p = 0.0112) was found, with the tinnitus group showing lower CARs (M = 5.1808, SD = 0.5821) than the comparison group (M = 5.9974; SD = 0.5251) in traumatised individuals only. No effects were found for baseline or post-dexamethasone cortisol. Anxiety scores had no effects on any of the outcome variables.
Conclusion: A differential effect of childhood trauma, but not anxiety, on the HPA-axis function in chronic subjective tinnitus was partly confirmed by the finding of a blunted CAR in tinnitus sufferers reporting early-life adversity.
DOI: 10.6084/m9.figshare.27861819
title: Supplementary Material for: Human Amniotic Membrane (hAM) graft in the management of Peripheral Hypertrophic Subepithelial Corneal Degeneration – A case report

description: Abstract: 

Introduction: 
In this report, we describe the case of Peripheral Hypertrophic Subepithelial Corneal Degeneration (PHSCD), managed with surgical excision and a human amniotic membrane (hAM) graft. In this article, we also propose a table for differential diagnosis, which might help physicians recognize this uncommon clinical entity in practice. 


Case presentation: 
A 45-year-old female Caucasian patient presented with decreased vision, itching and burning in both eyes, and a presence of pseudopterygium in the right eye, causing visual decline. Routine ocular exams an Anterior Segment OCT led to the diagnosis of PHSCD, after a careful differential diagnosis with other similar clinical occurrences. Subsequently, the patient was successfully managed with surgical intervention and an amniotic membrane graft placement. 


Conclusion: 
PHSCD is a rare disease, which in advanced cases can be successfully managed with hAM graft. No recurrence of the lesions was observed at one-year follow-up in our patient.
DOI: 10.6084/m9.figshare.27866610
title: Supplementary Material for: Patient Preferences with Anti–Vascular Endothelial Growth Factor Treatment for Neovascular Age-Related Macular Degeneration and Diabetic Macular Edema: A Multinational Discrete Choice Experiment Study

description: Introduction: New anti–vascular endothelial growth factor (VEGF) treatments are emerging for the treatment of diabetic macular edema (DME)/neovascular age-related macular degeneration (nAMD). This study aimed to explore the treatment attributes patients find important when deciding on treatment options. 

Methods: This noninterventional survey study assessed treatment preferences through a discrete choice experiment (DCE) among patients with DME/nAMD in the United States, Canada, France, Italy, Spain, and the United Kingdom. The DCE design was informed by a targeted literature review and qualitative interview research and included five treatment attributes: mode of administration, frequency of examinations, frequency of injections or refills, likely change in visual acuity, and eye-related side effects. Conditional logit models were used to analyze the choice data. 

Results: Overall, 537 patients completed the DCE (DME, n = 173; nAMD, n = 364). Patients reported preferring “injection” over “implant surgery and refills” and better visual outcomes over “stabilization”, which were also the most important attributes driving preference (35.1% and 31.5%, respectively). They also showed a preference for less-frequent treatment and examinations and for “mild-moderate, frequent” over “severe, rare” side effects. These findings were generally consistent across the two conditions, although significant differences were found depending on anti-VEGF treatment duration (nAMD, DME) and number of reported barriers (nAMD). 

Conclusion: Patient preferences for treatment are driven by several factors. Considering these is essential when designing/introducing new therapies. Individual treatment preferences should be identified and given key consideration when helping patients select from an expanding array of treatment options.
DOI: 10.18739/a2h41jn16
title: Autonomous Ice Mass Balance Buoys for an Arctic Observing Network

description: Please find the near real time data available at http://imb.crrel.usace.army.mil/ This award supports the deployment of ice mass balance (IMB) buoys as part of the Arctic Observing Network (AON) and the Study of Environmental Arctic Change (SEARCH). The autonomous, ice-based drifting buoys measure, delineate and, importantly, attribute thermodynamically-driven changes in the thickness of the ice cover. The IMBs will be deployed strategically and in coordination with other elements of AON to optimize the observation of changes and trends in sea ice throughout the Arctic Basin. The Broader Impacts of this award are many. IMB data have and will continue to assist large-scale modeling efforts to improve the treatment of ice growth and decay in GCMs and to assess the relative impact of ice thermodynamics on the observed changes in the Arctic sea ice cover. Results will also provide baseline data to support the development of instruments and algorithms to remotely sense snow depth, ice thickness, and the onset of freeze-up. More generally, this work presents an extraordinary opportunity to capture the attention and imagination of the public and of schoolchildren. The centerpiece of active commitment to educational outreach will be the design and implementation of the Adopt-a-Buoy program, where K-12 students will have the opportunity to name and follow a designated buoy after it is deployed in the Arctic. Our participation in a recently funded Integrative Graduate Education and Research Traineeship Program (IGERT), Polar Environmental Change with Dartmouth College, will facilitate the involvement of graduate students.
DOI: 10.18739/a2cc0tt6z
title: Searching for Abrupt Climate Change Precursors Using Ultra High Resolution Ice Core Analysis

description: The project will undertake an ultra high resolution, multi-parameter investigation of past climate to develop predictors for future abrupt climate change through identification of the "tipping points" which occur prior to an abrupt climate change events. Ultra-high resolution (up to 4 micron) ice core records will be produced -- well beyond the ~1cm resolution currently available -- using continuous flow injection into both a Thermo Element 2 ICP-MS and a Picarro Inc. L-2130-I H2O isotope analyzer sampled using a newly developed state-of-the-art cryocell chamber integrated with digital image recording and annotating software. The PI will look for precursors that reveal evidence of changes in, for example, the timing and magnitude of temperature, precipitation and atmospheric circulation from multi-decadal down to hundreds of sampling levels per year. The project will train students to be well versed in advanced laboratory and numerical modeling methods. Students will learn data reduction and visualization algorithms while also helping to provide a data stream that has broad applicability to climate. Cyberinfrastructure developed under NSF funding to the Climate Change Institute will be used to store, process, and visualize this high volume of ice core data while also making the information available to the public with high transparency for climate change use and attribution.
DOI: 10.21227/n68k-tc79
title: weibo-senti-100.zip

description:  Publicly available dataset weibo_senti_100k, which consists of Weibo comments, verify the validity of the model. We have assigned the label of 0 to negative semantics, 1 to neutral statements, and 2 to positive semantics in the dataset,comments data is divided into a training set, a test set and a validation set, distributed in a ratio of 3:1:1 to facilitate the training and evaluation of our machine learning model.
DOI: 10.5281/zenodo.10962520
title: GPR dataset: pulsed radar and SFCW data for rebar detection (experimental data)

description: GPR data corresponding to the article "Rebar detection: Comparison of stepped frequency continuous wave and pulsed GPR" presented in the 7th International Conference on Smart Monitoring, Assessment and Rehabilitation of Civil Structures (SMAR 2024). 

This work presents a comparison in rebar mapping between two GPR systems with different modulation techniques: Stepped frequency continuous wave (SFCW) and pulsed radar. The SFCW system used has a frequency range of 400-6000 MHz, while the pulsed system used a ground-coupled central frequency antenna of 2.3 GHz. Measurements were conducted on laboratory specimens, with rebar diameters ranging from 8 to 32 mm. Three different specimens were used, with one for calibration and other two to analyze both the horizontal and vertical resolutions of the frequency antennas.
description: The SFCW GPR data is provided by Screening Eagle Tech. 

The pulsed GPR data is provided by Universidade de Vigo.