cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.6016175.v1
title: HPLC JN-02 KAT-II IC50

description: KAT-II (0.5 μg) was incubated at 37 °C for 10 min in a 50 μL reaction mixture containing 50 μM PLP, 5 mM α-ketoglutarate, 5 mM l-kynurenine in PBS, pH 7.4, with the inhibitor being studied (1–2000 μM). Equal volume of formic acid (0.8M) was added to terminate the reaction, and 50 uL of this mixture was diluted to 1 mL. Kynurenine and KYNA produced during the reaction was analyzed by HPLC using a C18 reverse-phase column, with 50% (<i>v</i>/<i>v</i>) methanol and 50% (<i>v</i>/<i>v</i>) water used as the mobile phase. Kynurenine and KYNA were detection by UV detection at a wavelength of 330 nm.<br>
DOI: 10.6084/m9.figshare.6016166
title: HPLC JN-01 KAT-II IC50

description: KAT-II (0.5 μg) was incubated at 37 °C for 10 min in a 50 μL reaction mixture containing 50 μM PLP, 5 mM α-ketoglutarate, 5 mM l-kynurenine in PBS, pH 7.4, with the inhibitor being studied (1–2000 μM). Equal volume of formic acid (0.8M) was added to terminate the reaction, and 50 uL of this mixture was diluted to 1 mL. Kynurenine and KYNA produced during the reaction was analyzed by HPLC using a C18 reverse-phase column, with 50% (<i>v</i>/<i>v</i>) methanol and 50% (<i>v</i>/<i>v</i>) water used as the mobile phase. Kynurenine and KYNA were detection by UV detection at a wavelength of 330 nm.
DOI: 10.6084/m9.figshare.6016166.v1
title: HPLC JN-01 KAT-II IC50

description: KAT-II (0.5 μg) was incubated at 37 °C for 10 min in a 50 μL reaction mixture containing 50 μM PLP, 5 mM α-ketoglutarate, 5 mM l-kynurenine in PBS, pH 7.4, with the inhibitor being studied (1–2000 μM). Equal volume of formic acid (0.8M) was added to terminate the reaction, and 50 uL of this mixture was diluted to 1 mL. Kynurenine and KYNA produced during the reaction was analyzed by HPLC using a C18 reverse-phase column, with 50% (<i>v</i>/<i>v</i>) methanol and 50% (<i>v</i>/<i>v</i>) water used as the mobile phase. Kynurenine and KYNA were detection by UV detection at a wavelength of 330 nm.
DOI: 10.6084/m9.figshare.6016145
title: Data files for Mind Upload Studies

description: Four anonymized datasets used in our study published in Palgrave Communications. Analyses, psychometrics and formation of dependent and independent variables have been described in the manuscript. <br><br>Data for Study 3 is in Stata-13 format and contains 303 participants whom were analyzed. For the retained sample of 303 participants few missing values were imputed, as described in the manuscript. For full details regarding the non imputed data-set (not anonymized), please contact the authors if necessary. Stata 13.1 has a bug in its programming and it does not exporting .csv files correctly. <br><br>Variables related to geolocation, participant numbers and time stamps have been removed. Also personal questions related to possible psychological problems. sexual orientation, occupational details have been removed. Many of the variables have been translated to English. <br><br>We also collected political party affiliations and voting choices, which have been removed. Finland is a multi-party system and voting behavior, combined with age, gender, timestamps and location can be used to identify people. <br><br>For full description of the complete collected data the interested parties are encouraged to contact the authors.<br><br>Other exploratory variables not pertinent to the main study and not reported in the manuscript have also been removed, since this data will be used to explore other research questions and ideas to be published later. Once published, they will be made available as well.<br><br><br>
DOI: 10.6084/m9.figshare.6016145.v1
title: Data files for Mind Upload Studies

description: Four anonymized datasets used in our study published in Palgrave Communications. Analyses, psychometrics and formation of dependent and independent variables have been described in the manuscript. <br><br>Data for Study 3 is in Stata-13 format and contains 303 participants whom were analyzed. For the retained sample of 303 participants few missing values were imputed, as described in the manuscript. For full details regarding the non imputed data-set (not anonymized), please contact the authors if necessary. Stata 13.1 has a bug in its programming and it does not exporting .csv files correctly. <br><br>Variables related to geolocation, participant numbers and time stamps have been removed. Also personal questions related to possible psychological problems. sexual orientation, occupational details have been removed. Many of the variables have been translated to English. <br><br>We also collected political party affiliations and voting choices, which have been removed. Finland is a multi-party system and voting behavior, combined with age, gender, timestamps and location can be used to identify people. <br><br>For full description of the complete collected data the interested parties are encouraged to contact the authors.<br><br>Other exploratory variables not pertinent to the main study and not reported in the manuscript have also been removed, since this data will be used to explore other research questions and ideas to be published later. Once published, they will be made available as well.<br><br><br>
DOI: 10.6084/m9.figshare.6016112
title: SD2.xlsx

description: Full dataset to accompany "Characterisation of capsule genes in non-pathogenic Neisseria species", published in Microbial Genomics. Contains metadata and original source of pubMLST genomes, as well as the source and/or accession numbers of NCTC 3000 and GenBank genomes used in the study.
DOI: 10.6084/m9.figshare.6016112.v1
title: SD2.xlsx

description: Full dataset to accompany "Characterisation of capsule genes in non-pathogenic Neisseria species", published in Microbial Genomics. Contains metadata and original source of pubMLST genomes, as well as the source and/or accession numbers of NCTC 3000 and GenBank genomes used in the study.
DOI: 10.6084/m9.figshare.6016106
title: Etanercept glycoform assignment

description: ZIP archive containing raw spectra (in RAW and mzML format); MoFi parameter and output files; processed results and the corresponding processing scripts; glycopeptide data. See the readme file for further details.
DOI: 10.6084/m9.figshare.6016088
title: DATA.xlsx

description: Intrinsic and Extrinsic Variables data set of endemic neotropical birds, composed by body size, maximum clutch size, distribution range, diet, habitat and foraging breadths, natural proportion, Night light, Human Population and Human FootPrint.
DOI: 10.6084/m9.figshare.6015998
title: Dataset for: Progesterone administration does not acutely alter LH pulse secretion in the mid-follicular phase in women

description: It remains unclear how rapidly progesterone suppresses luteinizing hormone (LH) pulse frequency in women. Previous studies suggested that progesterone markedly increases LH pulse amplitude but does not slow LH pulse frequency within 10 hours in estradiol-pretreated women studied during the late follicular phase. However, this experimental paradigm may be a model of preovulatory physiology, and progesterone may have different effects at other times of the cycle. We studied regularly cycling, non-obese women without hyperandrogenism to assess the acute effect of progesterone during the mid-follicular phase and in the absence of estradiol pretreatment. The study involved two admissions in separate cycles (cycle days 5-9). For each admission, either oral micronized progesterone (100 mg) or placebo was administered at 0900 h in a randomized, double-blind fashion. Frequent blood sampling was performed between 0900 and 1900 h to define 10-hour LH pulsatility. Treatment crossover (placebo exchanged for progesterone and vice versa) occurred in a subsequent cycle. After an interim futility analysis, the study was halted after 7 women completed study. Mean progesterone concentrations after placebo and progesterone administration were 0.5 ± 0.1 (mean ± SD) and 6.7 ± 1.6 ng/ml, respectively. Compared to placebo, progesterone was not associated with a significant difference in 10-hour LH pulse frequency (0.79 ± 0.35 vs. 0.77 ± 0.28 pulses/hour, p = 1.0) or amplitude (3.6 ± 2.8 vs. 4.3 ± 2.8 IU/L, p = 0.30). This study suggests that LH pulse frequency is not rapidly influenced by progesterone administration during the mid-follicular phase.
DOI: 10.6084/m9.figshare.6015998.v1
title: Dataset for: Progesterone administration does not acutely alter LH pulse secretion in the mid-follicular phase in women

description: It remains unclear how rapidly progesterone suppresses luteinizing hormone (LH) pulse frequency in women. Previous studies suggested that progesterone markedly increases LH pulse amplitude but does not slow LH pulse frequency within 10 hours in estradiol-pretreated women studied during the late follicular phase. However, this experimental paradigm may be a model of preovulatory physiology, and progesterone may have different effects at other times of the cycle. We studied regularly cycling, non-obese women without hyperandrogenism to assess the acute effect of progesterone during the mid-follicular phase and in the absence of estradiol pretreatment. The study involved two admissions in separate cycles (cycle days 5-9). For each admission, either oral micronized progesterone (100 mg) or placebo was administered at 0900 h in a randomized, double-blind fashion. Frequent blood sampling was performed between 0900 and 1900 h to define 10-hour LH pulsatility. Treatment crossover (placebo exchanged for progesterone and vice versa) occurred in a subsequent cycle. After an interim futility analysis, the study was halted after 7 women completed study. Mean progesterone concentrations after placebo and progesterone administration were 0.5 ± 0.1 (mean ± SD) and 6.7 ± 1.6 ng/ml, respectively. Compared to placebo, progesterone was not associated with a significant difference in 10-hour LH pulse frequency (0.79 ± 0.35 vs. 0.77 ± 0.28 pulses/hour, p = 1.0) or amplitude (3.6 ± 2.8 vs. 4.3 ± 2.8 IU/L, p = 0.30). This study suggests that LH pulse frequency is not rapidly influenced by progesterone administration during the mid-follicular phase.
DOI: 10.6084/m9.figshare.6015992
title: Dataset for: The nuclear Retinoid-related Orphan Receptor RORα controls circadian thermogenic programming in white fat depots

description: The RORα–deficient staggerer (sg/sg) mouse is lean and resistant to diet-induced obesity. Its thermogenic activity was shown to be increased in brown adipose tissue (BAT), but also in subcutaneous white adipose tissue (WAT) where UCP1 content was enhanced, however without Prdm16 co-expression. Our observation of partial multilocular lipid morphology of WAT in sg/sg mice both in the inguinal and perigonadal sites led us to focus on the phenotype of both fat depots. Because RORα is a nuclear factor acting in the clock machinery, we looked at the circadian expression profile of genes involved in thermogenesis and browning in WAT and BAT depots of sg/sg and WT mice, through Real Time quantitative PCR and Western Blotting. This 24h-period-approach revealed both a rhythmic expression of thermogenic genes in WAT and an increased browning of all the WAT depots tested in sg/sg mice, that indeed involved the canonical browning process (through induction of Pgc-1α and Prdm16). This was associated with an enhanced isoproterenol-induced oxygen consumption rate of WAT explants from sg/sg mice, which was reproducible in WT explants by treatment with a RORα inverse agonist SR 3335, that induced a parallel increase of the UCP1 protein. Inhibitors of browning differentiation such as TLE3 and RIP140 could be new targets of RORα that would be rather implicated in the whitening of adipocytes. Our study showed the pivotal role of RORα as an inhibitor of the thermogenic program in WAT, role that could be counteracted in vivo with the RORα antagonists currently in development.
DOI: 10.6084/m9.figshare.6015992.v1
title: Dataset for: The nuclear Retinoid-related Orphan Receptor RORα controls circadian thermogenic programming in white fat depots

description: The RORα–deficient staggerer (sg/sg) mouse is lean and resistant to diet-induced obesity. Its thermogenic activity was shown to be increased in brown adipose tissue (BAT), but also in subcutaneous white adipose tissue (WAT) where UCP1 content was enhanced, however without Prdm16 co-expression. Our observation of partial multilocular lipid morphology of WAT in sg/sg mice both in the inguinal and perigonadal sites led us to focus on the phenotype of both fat depots. Because RORα is a nuclear factor acting in the clock machinery, we looked at the circadian expression profile of genes involved in thermogenesis and browning in WAT and BAT depots of sg/sg and WT mice, through Real Time quantitative PCR and Western Blotting. This 24h-period-approach revealed both a rhythmic expression of thermogenic genes in WAT and an increased browning of all the WAT depots tested in sg/sg mice, that indeed involved the canonical browning process (through induction of Pgc-1α and Prdm16). This was associated with an enhanced isoproterenol-induced oxygen consumption rate of WAT explants from sg/sg mice, which was reproducible in WT explants by treatment with a RORα inverse agonist SR 3335, that induced a parallel increase of the UCP1 protein. Inhibitors of browning differentiation such as TLE3 and RIP140 could be new targets of RORα that would be rather implicated in the whitening of adipocytes. Our study showed the pivotal role of RORα as an inhibitor of the thermogenic program in WAT, role that could be counteracted in vivo with the RORα antagonists currently in development.
DOI: 10.6084/m9.figshare.6015974
title: Treatment Outcomes with Biosimilars: Be Aware of the Nocebo Effect

description: <b>Article full text</b> <br> The full text of this article can be found here<b>.</b> https://link.springer.com/article/10.1007/s40744-017-0085-z <br> <b>Provide enhanced content for this article</b> <br> If you are an author of this publication and would like to provide additional enhanced content for your article then please contact <b>adisrapidplus@springer.com</b>. <br> The journal offers a range of additional features designed to increase visibility and readership. All features will be thoroughly peer reviewed to ensure the content is of the highest scientific standard and all features are marked as ‘peer reviewed’ to ensure readers are aware that the content has been reviewed to the same level as the articles they are being presented alongside. Moreover, all sponsorship and disclosure information is included to provide complete transparency and adherence to good publication practices. This ensures that however the content is reached the reader has a full understanding of its origin. No fees are charged for hosting additional open access content. <br> Other enhanced features include, but are not limited to: <br> • Slide decks • Videos and animations • Audio abstracts • Audio slides
DOI: 10.6084/m9.figshare.6015974.v2
title: Treatment Outcomes with Biosimilars: Be Aware of the Nocebo Effect

description: <b>Article full text</b> <br> The full text of this article can be found here<b>.</b> https://link.springer.com/article/10.1007/s40744-017-0085-z <br> <b>Provide enhanced content for this article</b> <br> If you are an author of this publication and would like to provide additional enhanced content for your article then please contact <b>adisrapidplus@springer.com</b>. <br> The journal offers a range of additional features designed to increase visibility and readership. All features will be thoroughly peer reviewed to ensure the content is of the highest scientific standard and all features are marked as ‘peer reviewed’ to ensure readers are aware that the content has been reviewed to the same level as the articles they are being presented alongside. Moreover, all sponsorship and disclosure information is included to provide complete transparency and adherence to good publication practices. This ensures that however the content is reached the reader has a full understanding of its origin. No fees are charged for hosting additional open access content. <br> Other enhanced features include, but are not limited to: <br> • Slide decks • Videos and animations • Audio abstracts • Audio slides
DOI: 10.6084/m9.figshare.6015974.v1
title: Treatment Outcomes with Biosimilars: Be Aware of the Nocebo Effect

description: <b>Article full text</b> <br> The full text of this article can be found here<b>.</b> https://link.springer.com/article/10.1007/s40744-017-0085-z <br> <b>Provide enhanced content for this article</b> <br> If you are an author of this publication and would like to provide additional enhanced content for your article then please contact <b>adisrapidplus@springer.com</b>. <br> The journal offers a range of additional features designed to increase visibility and readership. All features will be thoroughly peer reviewed to ensure the content is of the highest scientific standard and all features are marked as ‘peer reviewed’ to ensure readers are aware that the content has been reviewed to the same level as the articles they are being presented alongside. Moreover, all sponsorship and disclosure information is included to provide complete transparency and adherence to good publication practices. This ensures that however the content is reached the reader has a full understanding of its origin. No fees are charged for hosting additional open access content. <br> Other enhanced features include, but are not limited to: <br> • Slide decks • Videos and animations • Audio abstracts • Audio slides
DOI: 10.6084/m9.figshare.6015971
title: Supplementary Material for: Testosterone Deprivation Aggravates Left-Ventricular Dysfunction in Male Obese Insulin-Resistant Rats via Impairing Cardiac Mitochondrial Function and Dynamics Proteins

description: <b><i>Background:</i></b> We have previously reported that testosterone deprivation at a very young age accelerated, but did not aggravate, left-ventricular (LV) dysfunction in obese insulin-resistant rats. However, the effects of testosterone deprivation during adulthood on LV function in obese insulin-resistant rats remains unclear. We hypothesized that testosterone deprivation aggravates LV dysfunction and cardiac autonomic imbalance via the impairment of cardiac mitochondrial function and dynamics proteins, a reduction in insulin receptor function, and an increase in apoptosis in obese insulin-resistant rats. <b><i>Methods:</i></b> Male rats were fed on either a normal diet (ND) or a high-fat diet (HFD) for 12 weeks. They were then subdivided into 2 groups: sham operation (NDS, HFS) and orchiectomy (NDO, HFO). Metabolic parameters, blood pressure, heart rate variability (HRV), and LV function were determined at baseline and before and after orchiectomy. Mitochondrial function and dynamics proteins, insulin signaling, and apoptosis were determined 12 weeks postoperatively. <b><i>Results:</i></b> HFS rats exhibited obese insulin resistance, depressed HRV, and LV dysfunction. In HFO rats, systolic blood pressure was increased with more excessive depression of HRV and increased LV dysfunction, compared with HFS rats. These adverse cardiac effects were consistent with markedly increased mitochondrial dysfunction, reduced mitochondrial complex I and III proteins, reduced mitochondrial fusion proteins, and increased apoptosis, compared with HFS rats. However, testosterone deprivation did not lead to any alteration in the insulin-resistant condition in HFO rats, compared with HFS rats. <b><i>Conclusion:</i></b> We concluded that testosterone deprivation during adulthood aggravated the impairment of mitochondrial function, mitochondrial respiratory complex, mitochondrial dynamics proteins, and apoptosis, leading to LV dysfunction in obese insulin-resistant rats.
DOI: 10.6084/m9.figshare.6015959
title: Test data of electricity-gas UC

description: 1. Two integrated electrical and gas systems are included.2. Please refer to my paper "Unit Commitment of Integrated Electrical and Gas System with an Enhanced SOC Gas Flow Model" if published online.
DOI: 10.6084/m9.figshare.6015959.v1
title: Test data of electricity-gas UC

description: 1. Two integrated electrical and gas systems are included.2. Please refer to my paper "Unit Commitment of Integrated Electrical and Gas System with an Enhanced SOC Gas Flow Model" if published online.
DOI: 10.6084/m9.figshare.6015905
title: Brodalumab for the Treatment of Psoriasis: A Review of Phase III Trials

description: <b>Article full text</b> <br> The full text of this article can be found here<b>.</b> https://link.springer.com/article/10.1007/s13555-016-0121-x <br> <b>Provide enhanced content for this article</b> <br> If you are an author of this publication and would like to provide additional enhanced content for your article then please contact <b>adisrapidplus@springer.com</b>. <br> The journal offers a range of additional features designed to increase visibility and readership. All features will be thoroughly peer reviewed to ensure the content is of the highest scientific standard and all features are marked as ‘peer reviewed’ to ensure readers are aware that the content has been reviewed to the same level as the articles they are being presented alongside. Moreover, all sponsorship and disclosure information is included to provide complete transparency and adherence to good publication practices. This ensures that however the content is reached the reader has a full understanding of its origin. No fees are charged for hosting additional open access content. <br> Other enhanced features include, but are not limited to: <br> • Slide decks • Videos and animations • Audio abstracts • Audio slides
DOI: 10.6084/m9.figshare.6015905.v1
title: Brodalumab for the Treatment of Psoriasis: A Review of Phase III Trials

description: <b>Article full text</b> <br> The full text of this article can be found here<b>.</b> https://link.springer.com/article/10.1007/s13555-016-0121-x <br> <b>Provide enhanced content for this article</b> <br> If you are an author of this publication and would like to provide additional enhanced content for your article then please contact <b>adisrapidplus@springer.com</b>. <br> The journal offers a range of additional features designed to increase visibility and readership. All features will be thoroughly peer reviewed to ensure the content is of the highest scientific standard and all features are marked as ‘peer reviewed’ to ensure readers are aware that the content has been reviewed to the same level as the articles they are being presented alongside. Moreover, all sponsorship and disclosure information is included to provide complete transparency and adherence to good publication practices. This ensures that however the content is reached the reader has a full understanding of its origin. No fees are charged for hosting additional open access content. <br> Other enhanced features include, but are not limited to: <br> • Slide decks • Videos and animations • Audio abstracts • Audio slides
DOI: 10.6084/m9.figshare.6015902
title: Dataset - Assessing naturally acquired immune response and malaria treatment outcomes in Lagos, Nigeria

description: The study examined antibody responses against malaria<i> </i>and the influence on the efficacy of artemether-lumefantrine in Lagos, Nigeria. Plasma samples were collected prior to treatment from individuals presenting with uncomplicated malaria. Participants were stratified into early and late clearance groups. Luminex assay was used to profile antibody response specific to 21 malaria parasite antigens.Ethical approval was obtained from the Nigerian Institute of Medical Research, Nigeria. <br>