cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.31286149.v1
title: Aneuploidy, polyploidy, and loss of heterozygosity distinguish serial bloodstream isolates of <i>Candida albicans</i>

description: Supplemental data for Aneuploidy, polyploidy, and loss of heterozygosity distinguish serial bloodstream isolates of <i>Candida albicans.</i> <i>Candida albicans</i> is an important opportunistic fungal pathogen with extensive genomic variation. We performed comparative genomic and phenotypic analysis of 101 <i>C. albicans</i> bloodstream isolates collected from 55 patients in the Twin Cities region of Minnesota, including serial isolates from 19 patients. We analyzed the phylogenetic relationships of these isolates relative to 199 globally-collected public <i>C. albicans</i> genomes. This study’s regional isolates span the phylogenetic diversity of <i>C. albicans</i>; 6 isolates represent novel outliers to known clades. While all serial isolates from the same patient clustered together phylogenetically, we observed extensive large-scale genomic variation between serial isolates including polyploidy, aneuploidy, copy number variation, loss of heterozygosity, and chromosomal rearrangements. We demonstrated how a heterozygous <i>ERG251</i> variant drives azole tolerance in a clinical isolate from a patient with a history of recurrent infections. Using serial isolates, we demonstrated that polyploidy provides an adaptive advantage in the presence of fluconazole despite the absence of overt antifungal drug resistance. Our analysis of closely matched serial isolates reveals the genomic plasticity of <i>C. albicans</i> during invasive infections and identifies variation driving antifungal drug tolerance.The Illumina whole genome sequencing data is deposited at the NCBI SRA, Bioproject ID PRJNA1068683.Supplemental Figure S1: Maximum-likelihood, midpoint-rooted phylogenetic tree with 101 new isolates (this study) and 199 publicly available genomesSupplemental Figure S2: LOH patterns distinguish unrelated strainsSupplemental Figure S3: Single allele ERG251 dysfunction does not have a significant fitness cost and complementation of WT ERG251 allele increases azole sensitivitySupplemental Figure S4: Evidence for reciprocal translocation between Chr2 and Chr6 in isolate 60Supplemental Figure S5: Uncropped karyotype gels and Southern blotsSupplemental Figure S6: Deletion of orf19.4069 (and dubious orf19.4070) in clinical isolates from multiple phylogenetic cladesSupplemental Table S1: Strain table with MIC, SMG, MLST, clade, genome heterozygositySupplemental Table S2: Publicly availabe genomes analyzed in this studySupplemental Table S3: Pearson's correlation of heterozygosity and phenotypesSupplemental Table S4: Aneuploid isolate FACS and estimated relative copy number by read depth analysisSupplemental Table S5: CNV size, breakpoints and associated repeat regionsSupplemental Table S6: Gene amplifications and deletionsSupplemental Table S7: Primers used for WT ERG251 transformationSupplemental Table S8: CFU counts for Figure 7Archive of analysis scripts: 2024_Candida_albicans_MEC_analysis_github_files
DOI: 10.15468/dl.58jvjk
title: Occurrence Download

description: A dataset containing 18 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Eryngium glaziovianum",
 "HasCoordinate is true",
 "OccurrenceStatus is Present",
 {
 "not" : {
 "BasisOfRecord" : [
 "is Fossil"
 ]
 }
 }
 ]
}

 The dataset includes 18 records from 9 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0008489-260208012135463/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.17909/mhby-a603
title: G140M spectrum of Jupiter's northern auroras
DOI: 10.15468/dl.rss5fd
title: Occurrence Download

description: A dataset containing 11 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Tympanopleura cryptica",
 "DecimalLatitude is not null",
 "DecimalLongitude is not null"
 ]
}

 The dataset includes 11 records from 7 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0008490-260208012135463/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.5517/ccdc.csd.cc2873l7
title: CCDC 2092208: Experimental Crystal Structure Determination

description: Related Article: Trevor L. Olson, Ariela W. Kaspi-Kaneti, Adrian Zając, Dominic Agyei Gyimah, Austin Walsh, Jacob A. Weston, Alexander A. Rusakov, Kraig A. Wheeler, Béla Török, Roman Dembinski|2026|ACS Org. Inorg. Au|||doi:10.1021/acsorginorgau.5c00116
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2bhm3l
title: CCDC 2159959: Experimental Crystal Structure Determination

description: Related Article: Parth Raval, Soumik Sao, Triza Pal, Tomasz Pawlak, Sayan Bhattacharjee, Rohit Bhowal, Sayantan Khan, Deepak Chopra, Debangshu Chaudhuri, G. N. Manjunatha Reddy|2026|J.Phys.Chem.C|||doi:10.1021/acs.jpcc.5c07222
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2ffxld
title: CCDC 2247704: Experimental Crystal Structure Determination

description: Related Article: Zhenzhen Yang, Feng Xu, Guan Wang, Yan Ran, Jian Wang, Jiaxin Teng, Yanghong Lv, Zhelin Fang, Yutong Ye, Xinkai Ye, Yijing Zhou, Weiqiang Yang, Jianbo Yan|2026|ChemMedChem|21|e202501008|doi:10.1002/cmdc.202501008
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2ffxmf
title: CCDC 2247705: Experimental Crystal Structure Determination

description: Related Article: Zhenzhen Yang, Feng Xu, Guan Wang, Yan Ran, Jian Wang, Jiaxin Teng, Yanghong Lv, Zhelin Fang, Yutong Ye, Xinkai Ye, Yijing Zhou, Weiqiang Yang, Jianbo Yan|2026|ChemMedChem|21|e202501008|doi:10.1002/cmdc.202501008
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2fpjwk
title: CCDC 2255029: Experimental Crystal Structure Determination

description: Related Article: Masayuki Kato, Fumio Nakashima, Naoya Ohtsuka, Yukina Nishioka, Atsuto Izumiseki, Takeshi Fujinami, Shunya Oishi, Toshiyasu Suzuki, Norie Momiyama|2026|J.Org.Chem.|||doi:10.1021/acs.joc.5c02704
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2fpjxl
title: CCDC 2255030: Experimental Crystal Structure Determination

description: Related Article: Masayuki Kato, Fumio Nakashima, Naoya Ohtsuka, Yukina Nishioka, Atsuto Izumiseki, Takeshi Fujinami, Shunya Oishi, Toshiyasu Suzuki, Norie Momiyama|2026|J.Org.Chem.|||doi:10.1021/acs.joc.5c02704
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2fpjym
title: CCDC 2255031: Experimental Crystal Structure Determination

description: Related Article: Masayuki Kato, Fumio Nakashima, Naoya Ohtsuka, Yukina Nishioka, Atsuto Izumiseki, Takeshi Fujinami, Shunya Oishi, Toshiyasu Suzuki, Norie Momiyama|2026|J.Org.Chem.|||doi:10.1021/acs.joc.5c02704
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2fpjzn
title: CCDC 2255032: Experimental Crystal Structure Determination

description: Related Article: Masayuki Kato, Fumio Nakashima, Naoya Ohtsuka, Yukina Nishioka, Atsuto Izumiseki, Takeshi Fujinami, Shunya Oishi, Toshiyasu Suzuki, Norie Momiyama|2026|J.Org.Chem.|||doi:10.1021/acs.joc.5c02704
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2g0pck
title: CCDC 2264778: Experimental Crystal Structure Determination

description: Related Article: Masayuki Kato, Fumio Nakashima, Naoya Ohtsuka, Yukina Nishioka, Atsuto Izumiseki, Takeshi Fujinami, Shunya Oishi, Toshiyasu Suzuki, Norie Momiyama|2026|J.Org.Chem.|||doi:10.1021/acs.joc.5c02704
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2g0pdl
title: CCDC 2264779: Experimental Crystal Structure Determination

description: Related Article: Masayuki Kato, Fumio Nakashima, Naoya Ohtsuka, Yukina Nishioka, Atsuto Izumiseki, Takeshi Fujinami, Shunya Oishi, Toshiyasu Suzuki, Norie Momiyama|2026|J.Org.Chem.|||doi:10.1021/acs.joc.5c02704
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2ggl5q
title: CCDC 2278133: Experimental Crystal Structure Determination

description: Related Article: Masayuki Kato, Fumio Nakashima, Naoya Ohtsuka, Yukina Nishioka, Atsuto Izumiseki, Takeshi Fujinami, Shunya Oishi, Toshiyasu Suzuki, Norie Momiyama|2026|J.Org.Chem.|||doi:10.1021/acs.joc.5c02704
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2ggl8t
title: CCDC 2278136: Experimental Crystal Structure Determination

description: Related Article: Masayuki Kato, Fumio Nakashima, Naoya Ohtsuka, Yukina Nishioka, Atsuto Izumiseki, Takeshi Fujinami, Shunya Oishi, Toshiyasu Suzuki, Norie Momiyama|2026|J.Org.Chem.|||doi:10.1021/acs.joc.5c02704
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2ggl9v
title: CCDC 2278137: Experimental Crystal Structure Determination

description: Related Article: Masayuki Kato, Fumio Nakashima, Naoya Ohtsuka, Yukina Nishioka, Atsuto Izumiseki, Takeshi Fujinami, Shunya Oishi, Toshiyasu Suzuki, Norie Momiyama|2026|J.Org.Chem.|||doi:10.1021/acs.joc.5c02704
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2hfppb
title: CCDC 2307072: Experimental Crystal Structure Determination

description: Related Article: Yuxuan Yang, Xintong Ji, Enming Ping, Lingyun Kong, Liming Sun, Lijuan Zhang, Yunshan Zhou|2026|Int.J.Hydro.Eneg|205|153264|doi:10.1016/j.ijhydene.2025.153264
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2jsqgj
title: CCDC 2347458: Experimental Crystal Structure Determination

description: Related Article: Yong Wang, Qiaoqiao Zhang, Qi Liu, Brendan F. Abrahams, Jian-Ping Lang|2024|Angew.Chem.,Int.Ed.|63|e202409472|doi:10.1002/anie.202409472
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2jsqhk
title: CCDC 2347459: Experimental Crystal Structure Determination

description: Related Article: Yong Wang, Qiaoqiao Zhang, Qi Liu, Brendan F. Abrahams, Jian-Ping Lang|2024|Angew.Chem.,Int.Ed.|63|e202409472|doi:10.1002/anie.202409472
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2jsqjl
title: CCDC 2347460: Experimental Crystal Structure Determination

description: Related Article: Yong Wang, Qiaoqiao Zhang, Qi Liu, Brendan F. Abrahams, Jian-Ping Lang|2024|Angew.Chem.,Int.Ed.|63|e202409472|doi:10.1002/anie.202409472
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2kvb0s
title: CCDC 2378785: Experimental Crystal Structure Determination

description: Related Article: zhuangzhi Shi, Hairui Ni, Xinyuan Zhao, Xinyuan Chang, Jianduo Yang, Yongqiang Xie, Tongyan Yu, Siliang You, Chao Deng|2025|J.Heterocycl.Chem.|62|1390|doi:10.1002/jhet.70078
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2kybb6
title: CCDC 2381678: Experimental Crystal Structure Determination

description: Related Article: Julio Belmar Mellado, Kristofer Bonilla Winter, Claudio Jiménez Águila, Lucas Romero Albornoz, Tomás Soto Cerna, David Villamán Figueroa|2025|J.Heterocycl.Chem.|62|1396|doi:10.1002/jhet.70034
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2kybc7
title: CCDC 2381679: Experimental Crystal Structure Determination

description: Related Article: Julio Belmar Mellado, Kristofer Bonilla Winter, Claudio Jiménez Águila, Lucas Romero Albornoz, Tomás Soto Cerna, David Villamán Figueroa|2025|J.Heterocycl.Chem.|62|1396|doi:10.1002/jhet.70034
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2l1lfp
title: CCDC 2384812: Experimental Crystal Structure Determination

description: Related Article: Xiang Gao, Xiaowei Zhao, Wanqing Zhao, Anxu Pan, Man Zhang, Nengneng Zhou|2025|Chem.Asian J.|20|e00919|doi:10.1002/asia.202500919
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2l6yyq
title: CCDC 2389974: Experimental Crystal Structure Determination

description: Related Article: Jiongfeng Li, Huaye Tong, Jiangshang Su, Xingya Fan, Zhifen Guo, Daofei Lv, Feng Xu, Junjie Peng, Xun Wang, Jian Yan, Zewei Liu, Xin Chen, Hongxia Xi, Qibin Xia|2025|Chem.Eng.Sci.|318|122228|doi:10.1016/j.ces.2025.122228
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2ldggy
title: CCDC 2395260: Experimental Crystal Structure Determination

description: Related Article: Mostafa A. El-Naggar, Morsy A. M. Abu-Youssef, Matti Haukka, Assem Barakat, Ayman El-Faham, Saied M. Soliman, Amal Yousri|2025|Inorg.Chim.Acta|587|122810|doi:10.1016/j.ica.2025.122810
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2ldghz
title: CCDC 2395261: Experimental Crystal Structure Determination

description: Related Article: Mostafa A. El-Naggar, Morsy A. M. Abu-Youssef, Matti Haukka, Assem Barakat, Ayman El-Faham, Saied M. Soliman, Amal Yousri|2025|Inorg.Chim.Acta|587|122810|doi:10.1016/j.ica.2025.122810
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2ldhr8
title: CCDC 2395300: Experimental Crystal Structure Determination

description: Related Article: Mostafa A. El-Naggar, Morsy A. M. Abu-Youssef, Matti Haukka, Assem Barakat, M. Ali, Ayman El-Faham, Saied M. Soliman, Amal Yousri|2025|Appl.Organomet.Chem.|39|e70394|doi:10.1002/aoc.70394
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2ldhs9
title: CCDC 2395301: Experimental Crystal Structure Determination

description: Related Article: Mostafa A. El-Naggar, Morsy A. M. Abu-Youssef, Matti Haukka, Assem Barakat, M. Ali, Ayman El-Faham, Saied M. Soliman, Amal Yousri|2025|Appl.Organomet.Chem.|39|e70394|doi:10.1002/aoc.70394
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2lp5n4
title: CCDC 2403636: Experimental Crystal Structure Determination

description: Related Article: Shruti Verma, Udit Kumar, Gnanamary Thomas, Santhakumar Yeswanth Kumar, Diksha Tripathi, Ramanathan Padmanaban, Natarajan Sakthivel, Bala Manimaran|2025|ACS Omega|10|53760|doi:10.1021/acsomega.4c10992
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.