cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.1294944.v1
title: Comparing the health state preferences of older persons, informal caregivers, and healthcare professionals: a vignette study

description: <strong>Abstract</strong> <em><strong>Background</strong></em> The Older Persons and Informal Caregivers Survey- Minimum Dataset (TOPICS-MDS) collects uniform information from research projects funded under the Dutch National Care for the Elderly Programme. To compare the effectiveness of these projects a reference-weighted outcome measure that combined multidimensional TOPICS-MDS outcomes into a composite endpoint (TOPICS-CEP) was developed based on the health state preferences of olde persons and informal caregivers. <strong>Objectives</strong> To derive preference weights for TOPICS-CEP’s components based on health state preferences of healthcare professionals and to investigate whether these weights differ between disciplines and differ from those of older persons and informal caregivers. <em><strong>Materials and methods</strong></em> Vignette studies were conducted. Participants assessed the general wellbeing of older persons described in vignettes on a scale (0-10). Mixed linear analyses were used to obtain and compare the preference weights of the eight TOPICS-CEP components: morbidities, functional limitations, emotional wellbeing, pain experience, cognitive problems, social functioning, self-perceived health, and self-perceived quality of life (QOL). <strong><em>Results</em></strong> Overall, 330 healthcare professionals, 124 older persons and 76 informal caregivers participated. The preference weights were not significantly different between disciplines. However, the professionals’ preference weights differed significantly from those of older persons and informal caregivers. Morbidities and functional limitations were given more weight by older persons and informal caregivers than by healthcare professionals [difference between preference weights: 0.12 and 0.07] while the opposite was true for pain experience, social functioning, and self-perceived QOL [difference between preference weights: 0.13, 0.15 and 0.26]. <em><strong>Conclusion</strong></em> It is important to recognize the discrepancies between the health state preferences of various stakeholders to (1) correctly interpret results when studying the effectiveness of interventions in elderly care and (2) establish appropriate healthcare policies. Furthermore, we should strive to include older persons in our decision making process trough a shared decision making approach.
DOI: 10.6084/m9.figshare.1294943.v1
title: Comparing the health state preferences of older persons, informal

description: <strong>Abstract</strong> <em><strong>Background</strong></em> The Older Persons and Informal Caregivers Survey– Minimum Dataset (TOPICS-MDS) collects uniform information from research projects funded under the Dutch National Care for the Elderly Programme. To compare the effectiveness of these projects a preference-weighted outcome measure that combined multidimensional TOPICS-MDS outcomes into a composite endpoint (TOPICS-CEP) was developed based on the health state preferences of older persons and informal caregivers. <em></em> <strong><em>Objectives</em></strong> To derive preference weights for TOPICS-CEP’s components based on health state preferences of healthcare professionals and to investigate whether these weights differ between disciplines and differ from those of older persons and informal caregivers. <strong><em>Materials and methods</em></strong> Vignette studies were conducted. Participants assessed the general wellbeing of older persons described in vignettes on a scale (0-10). Mixed linear analyses were used to obtain and compare the preference weights of the eight TOPICS-CEP components: morbidities, functional limitations, emotional wellbeing, pain experience, cognitive problems, social functioning, self-perceived health, and self-perceived quality of life (QOL). <strong><em></em></strong> <strong><em>Results</em></strong> Overall, 330 healthcare professionals, 124 older persons and 76 informal caregivers participated. The preference weights were not significantly different between disciplines. However, the professionals’ preference weights differed significantly from those of older persons and informal caregivers. Morbidities and functional limitations were given more weight by older persons and informal caregivers than by healthcare professionals [difference between preference weights: 0.12 and 0.07] while the opposite was true for pain experience, social functioning, and self-perceived QOL [difference between preference weights: 0.13, 0.15 and 0.26]. <em><strong></strong></em> <em><strong>Conclusion</strong></em> It is important to recognize the discrepancies between the health state preferences of various stakeholders to (1) correctly interpret results when studying the effectiveness of interventions in elderly care and (2) establish appropriate healthcare policies. Furthermore, we should strive to include older persons in our decision making process through a shared decision making approach.
DOI: 10.6084/m9.figshare.1294928
title: PLOS1 Bush Mainen simulator "Columnar architecture improves noise robustness in a model cortical network"

description: simulator plus support files, readme
DOI: 10.6084/m9.figshare.1294902
title: Royal Holloway APCs 2014

description: This spreadsheet contains details of article processing charges (APCs) paid by Royal Holloway during 2014. The data is being collected as part of Jisc's APC data collection project to address the Total Cost of Ownership of scholarly communication (https://www.jisc-collections.ac.uk/Jisc-Monitor/APC-data-collection/) and has been released with permission of the Royal Holloway Library.
DOI: 10.6084/m9.figshare.1294902.v1
title: Royal Holloway APCs 2014

description: This spreadsheet contains details of article processing charges (APCs) paid by Royal Holloway during 2014. The data is being collected as part of Jisc's APC data collection project to address the Total Cost of Ownership of scholarly communication (https://www.jisc-collections.ac.uk/Jisc-Monitor/APC-data-collection/) and has been released with permission of the Royal Holloway Library.
DOI: 10.6084/m9.figshare.1294897
title: Infographics

description: A collection of infographics used in papers and presentations on Teacher Education in International Development Contexts, by the Open University and partners around the world.
DOI: 10.6084/m9.figshare.1294928.v2
title: PLOS1 Bush Mainen simulator "Columnar architecture improves noise robustness in a model cortical network"

description: simulator plus support files, readme
DOI: 10.6084/m9.figshare.1294928.v1
title: PLOS1 Bush Mainen simulator

description: simulator plus support files, readme
DOI: 10.6084/m9.figshare.1294897.v2
title: Infographics

description: A collection of infographics used in papers and presentations on Teacher Education in International Development Contexts, by the Open University and partners around the world.
DOI: 10.6084/m9.figshare.1294897.v1
title: Infographics

description: A collection of infographics used in papers and presentations on Teacher Education in International Development Contexts, by the Open University and partners around the world.
DOI: 10.6084/m9.figshare.1294876
title: Data from "Shape matters: lifecycle of cooperative patches promotes cooperation in bulky populations"

description: All data used to generate figures in the main text and the supplementary material for the "Shape matters: lifecycle of cooperative patches promotes cooperation in bulky populations" paper in Evolution journal.
DOI: 10.6084/m9.figshare.1294876.v1
title: Data from "Shape matters: lifecycle of cooperative patches promotes cooperation in bulky populations"

description: All data used to generate figures in the main text and the supplementary material for the "Shape matters: lifecycle of cooperative patches promotes cooperation in bulky populations" paper in Evolution journal.
DOI: 10.6084/m9.figshare.1294803
title: University of Liverpool APCs 2014

description: This spreadsheet contains details of article processing charges (APCs) paid by the University of Liverpool during 2014. The data is being collected as part of Jisc's APC data collection project to address the Total Cost of Ownership of scholarly communication (https://www.jisc-collections.ac.uk/Jisc-Monitor/APC-data-collection/) and has been released with permission of the University of Liverpool Library.
DOI: 10.6084/m9.figshare.1294802
title: Plymouth University APCs 2014

description: This spreadsheet contains details of article processing charges (APCs) paid by Plymouth University during 2014. The data is being collected as part of Jisc's APC data collection project to address the Total Cost of Ownership of scholarly communication (https://www.jisc-collections.ac.uk/Jisc-Monitor/APC-data-collection/) and has been released with permission of the Plymouth University Library.
DOI: 10.6084/m9.figshare.1294801
title: Inhibition of pseudotype virus entry by existing FDA-approved drugs

description: 293T cells were transfected 24hours previous then mixed with set dilutions of drug and infected with PVs (carried out in triplicate). After 48hours incubation firefly and Renilla values were measured using FLUOstar Omega plate reader (BMG Labtech). Firelfly values were normalised to the corresponding Renilla value. Percent infection at each dilution was calculated using the average values of the untreated control. *values for both ESOM and OM were shared and performed on the same 96-well plate.
DOI: 10.6084/m9.figshare.1294802.v1
title: Plymouth University APCs 2014

description: This spreadsheet contains details of article processing charges (APCs) paid by Plymouth University during 2014. The data is being collected as part of Jisc's APC data collection project to address the Total Cost of Ownership of scholarly communication (https://www.jisc-collections.ac.uk/Jisc-Monitor/APC-data-collection/) and has been released with permission of the Plymouth University Library.
DOI: 10.6084/m9.figshare.1294803.v1
title: University of Liverpool APCs 2014

description: This spreadsheet contains details of article processing charges (APCs) paid by the University of Liverpool during 2014. The data is being collected as part of Jisc's APC data collection project to address the Total Cost of Ownership of scholarly communication (https://www.jisc-collections.ac.uk/Jisc-Monitor/APC-data-collection/) and has been released with permission of the University of Liverpool Library.
DOI: 10.6084/m9.figshare.1294799
title: Natural hybridization in eastern-Mediterranean firs: The case of <i>Abies borisii-regis</i>

description: The genus <i>Abies</i> is represented in southern Balkans by <i>A. alba</i>, <i>A. cephalonica</i>, and <i>A. borisii-regis</i>. To infer the status of southern-Balkans firs, as well as the extent and patterns of introgression within this taxonomical complex, we analyzed genetic variation patterns of 29 indigenous fir populations in Bulgaria, Macedonia, Greece, and Calabria using a combination of maternally and biparentally inherited markers. Three mitochondrial lineages were observed, one comprising Calabrian populations and two distributed in the Balkans, coinciding with <i>A. alba</i> and <i>A. cephalonica</i>. The boundary between lineages is sharp; only two populations containing a mixture of haplotypes were found. Bayesian analysis of population structure based on seven nuclear microsatellite (nSSR) loci revealed the existence of two clusters whose proportions exhibited a latitudinal cline with a width of 2.3° ( ≈ 255 km). Populations in the center of the latitudinal cline exhibit the most symmetrical, the flattest, and the broadest distributions of cluster proportions within individual tree genomes. A neighbor-net network reflects the cline resulting from the Bayesian analysis. The observed variation patterns are not consistent with the hypothesis of <i>A. borisii-regis</i> as a monophyletic taxon or a stabilized hybridogenous species resulted from ancient hybridization; the taxon rather is a product of recent introgression.
DOI: 10.6084/m9.figshare.1294799.v2
title: Natural hybridization in eastern-Mediterranean firs: The case of <i>Abies borisii-regis</i>

description: The genus <i>Abies</i> is represented in southern Balkans by <i>A. alba</i>, <i>A. cephalonica</i>, and <i>A. borisii-regis</i>. To infer the status of southern-Balkans firs, as well as the extent and patterns of introgression within this taxonomical complex, we analyzed genetic variation patterns of 29 indigenous fir populations in Bulgaria, Macedonia, Greece, and Calabria using a combination of maternally and biparentally inherited markers. Three mitochondrial lineages were observed, one comprising Calabrian populations and two distributed in the Balkans, coinciding with <i>A. alba</i> and <i>A. cephalonica</i>. The boundary between lineages is sharp; only two populations containing a mixture of haplotypes were found. Bayesian analysis of population structure based on seven nuclear microsatellite (nSSR) loci revealed the existence of two clusters whose proportions exhibited a latitudinal cline with a width of 2.3° ( ≈ 255 km). Populations in the center of the latitudinal cline exhibit the most symmetrical, the flattest, and the broadest distributions of cluster proportions within individual tree genomes. A neighbor-net network reflects the cline resulting from the Bayesian analysis. The observed variation patterns are not consistent with the hypothesis of <i>A. borisii-regis</i> as a monophyletic taxon or a stabilized hybridogenous species resulted from ancient hybridization; the taxon rather is a product of recent introgression.
DOI: 10.6084/m9.figshare.1294799.v1
title: Natural hybridization in eastern-Mediterranean firs: The case of <i>Abies borisii-regis</i>

description: The genus <i>Abies</i> is represented in southern Balkans by <i>A. alba</i>, <i>A. cephalonica</i> and <i>A. borisii-regis</i>. To infer the status of southern-Balkans firs, as well as the extent and patterns of introgression within this taxonomical complex, we analyzed genetic variation patterns of 29 indigenous fir populations in Bulgaria, Macedonia, Greece and Calabria using a combination of maternally and biparentally inherited markers. Three mitochondrial lineages were observed, one comprising Calabrian populations and two distributed in the Balkans, coinciding with <i>A. alba</i> and <i>A. cephalonica</i>. The boundary between lineages is sharp; only two populations containing a mixture of haplotypes were found. Bayesian analysis of population structure based on seven nSSR loci revealed the existence of two clusters whose proportions exhibited a latitudinal cline with a width of 2.3° ( ≈ 255 km). Populations in the center of the latitudinal cline exhibit the most symmetrical, the flattest and the broadest distributions of cluster proportions within individual tree genomes. A neighbour-net network reflects the cline resulting from the Bayesiananalysis. The observed variation patterns are not consistent with the hypothesis of <i>A. borisii-regis</i> as a monophyletic taxon or a stabilized hybridogenous species resulted from ancient hybridization, the taxon rather is a product of recent introgression.
DOI: 10.6084/m9.figshare.1294744
title: Taxi GPS data for Beijing ring roads

description: This dataset is for paper: Jingyuan Wang, Yu Mao, Jing Li, Zhang Xiong, Wen-Xu Wang. Predictability of road traffic and congestion in urban areas.
DOI: 10.6084/m9.figshare.1294743
title: Future of Scholarly communication through Social Media

description: The Ubiquity of social media in the 21st century has put the scientific community to rethink the<br>traditional way of publication model as present mode of publication not only costly to produce scientific<br>knowledge but also costly to publish, managing and access it, it is also slow in the transmission as<br>compared in Social media platform.
DOI: 10.6084/m9.figshare.1294716
title: Microbe-Vinculin cross reactivity provides a molecular basis for the HLA-RA connection

description: Molecular modelling of DERAA peptides in complex with HLA-DQ molecules as determined by energy minimization or molecular dynamics. See Supplementary Notes for additonal information.
DOI: 10.6084/m9.figshare.1294712
title: DQ8 MD-PDB file

description: DQ8-vinculin complex. for more details: see note
DOI: 10.6084/m9.figshare.1294716.v2
title: Microbe-Vinculin cross reactivity provides a molecular basis for the HLA-RA connection

description: Molecular modelling of DERAA peptides in complex with HLA-DQ molecules as determined by energy minimization or molecular dynamics. See Supplementary Notes for additonal information.
DOI: 10.6084/m9.figshare.1294711
title: EM DQ8_004.PDB

description: DQ8-DERAA complex. for more details: see note
DOI: 10.6084/m9.figshare.1294710
title: EM DQ8_003.PDB

description: DQ8-DERAA complex. for more details: see note
DOI: 10.6084/m9.figshare.1294712.v1
title: DQ8 MD-PDB file

description: DQ8-vinculin complex. for more details: see note
DOI: 10.6084/m9.figshare.1294716.v1
title: Vinculin-DQ8 dcd-file

description: DCD-file of Vinculin in complex with HLA-DQ8.
DOI: 10.6084/m9.figshare.1294708
title: EM DQ8_001.PDB

description: DQ8-DERAA complex. for more details: see note
DOI: 10.6084/m9.figshare.1294710.v1
title: EM DQ8_003.PDB

description: DQ8-DERAA complex. for more details: see note
DOI: 10.6084/m9.figshare.1294711.v1
title: EM DQ8_004.PDB

description: DQ8-DERAA complex. for more details: see note
DOI: 10.6084/m9.figshare.1294708.v1
title: EM DQ8_001.PDB

description: DQ8-DERAA complex. for more details: see note
DOI: 10.6084/m9.figshare.1294709
title: EM DQ8_002.PDB

description: DQ8-DERAA complex. for more details: see note
DOI: 10.6084/m9.figshare.1294709.v1
title: EM DQ8_002.PDB

description: DQ8-DERAA complex. for more details: see note
DOI: 10.6084/m9.figshare.1294209
title: Benchmark for Fingerprint Segmentation Performance Evaluation

description: Benchmark Dataset for Fingerprint Segmentation Performance Evaluation. Contains manually marked ground truth segmentation for 10560 images from FVC2000, FVC2002 and FVC2004. Published together with the paper: "Filter Design and Performance Evaluation for Fingerprint Image Segmentation". Preprint available at: http://arxiv.org/abs/1501.02113
DOI: 10.6084/m9.figshare.1294210
title: Matlab Implementation of the FDB Method for Fingerprint Segmentation

description: Matlab implementation of the method described in: "Filter Design and Performance Evaluation for Fingerprint Image Segmentation" by Duy Hoang Thai, Stephan Huckermann, and Carsten Gottschlich A preprint is available at: http://arxiv.org/abs/1501.02113 The Benchmark for Fingerprint Segmentation Performance Evaluation<br>(manually marked ground truth information for 10560 images)<br>is available at: http://dx.doi.org/10.6084/m9.figshare.1294209
DOI: 10.6084/m9.figshare.1294153
title: MySciBlog Survey Topline Results

description: #MySciBlog Survey instrument and select topline frequency report. Survey of 610 science bloggers in 2014. All data collected by Paige Brown Jarreau, for dissertation work at Louisiana State University.
DOI: 10.6084/m9.figshare.1294153.v2
title: MySciBlog Survey Topline Results

description: #MySciBlog Survey instrument and select topline frequency report. Survey of 610 science bloggers in 2014. All data collected by Paige Brown Jarreau, for dissertation work at Louisiana State University.
DOI: 10.6084/m9.figshare.1294147.v1
title: The cell cycle regulator Ecdysoneless cooperates with H-Ras to promote oncogenic transformation of human mammary epithelial cells

description: The mammalian ortholog of Drosophila ecdysoneless (Ecd) gene product regulates Rb-E2F interaction and is required for cell cycle progression. Ecd is overexpressed in breast cancer and its overexpression predicts shorter survival in patients with ErbB2-positive tumors. Here, we demonstrate Ecd knock down (KD) in human mammary epithelial cells (hMECs) induces growth arrest, similar to the impact of Ecd Knock out (KO) in mouse embryonic fibroblasts. Furthermore, whole-genome mRNA expression analysis of control vs. Ecd KD in hMECs demonstrated that several of the top 40 genes that were down-regulated were E2F target genes. To address the role of Ecd in mammary oncogenesis, we overexpressed Ecd and/or mutant H-Ras in hTERT-immortalized hMECs. Cell cycle analyses revealed hMECs overexpressing Ecd+Ras showed incomplete arrest in G1 phase upon growth factor deprivation, and more rapid cell cycle progression in growth factor-containing medium. Analyses of cell migration, invasion, acinar structures in 3-D Matrigel and anchorage-independent growth demonstrated that Ecd+Ras-overexpressing cells exhibit substantially more dramatic transformed phenotype as compared to cells expressing vector, Ras or Ecd. Under conditions of nutrient deprivation, Ecd+Ras-overexpressing hMECs exhibited better survival, with substantial upregulation of the autophagy marker LC3 both at the mRNA and protein levels. Significantly, while hMECs expressing Ecd or mutant Ras alone did not form tumors in NOD/SCID mice, Ecd+Ras-overexpressing hMECs formed tumors, clearly demonstrating oncogenic cooperation between Ecd and mutant Ras. Collectively, we demonstrate an important co-oncogenic role of Ecd in the progression of mammary oncogenesis through promoting cell survival.
DOI: 10.6084/m9.figshare.1294147.v3
title: The cell cycle regulator ecdysoneless cooperates with H-Ras to promote oncogenic transformation of human mammary epithelial cells

description: The mammalian ortholog of Drosophila ecdysoneless (Ecd) gene product regulates Rb-E2F interaction and is required for cell cycle progression. Ecd is overexpressed in breast cancer and its overexpression predicts shorter survival in patients with ErbB2-positive tumors. Here, we demonstrate Ecd knock down (KD) in human mammary epithelial cells (hMECs) induces growth arrest, similar to the impact of Ecd Knock out (KO) in mouse embryonic fibroblasts. Furthermore, whole-genome mRNA expression analysis of control vs. Ecd KD in hMECs demonstrated that several of the top 40 genes that were down-regulated were E2F target genes. To address the role of Ecd in mammary oncogenesis, we overexpressed Ecd and/or mutant H-Ras in hTERT-immortalized hMECs. Cell cycle analyses revealed hMECs overexpressing Ecd+Ras showed incomplete arrest in G1 phase upon growth factor deprivation, and more rapid cell cycle progression in growth factor-containing medium. Analyses of cell migration, invasion, acinar structures in 3-D Matrigel and anchorage-independent growth demonstrated that Ecd+Ras-overexpressing cells exhibit substantially more dramatic transformed phenotype as compared to cells expressing vector, Ras or Ecd. Under conditions of nutrient deprivation, Ecd+Ras-overexpressing hMECs exhibited better survival, with substantial upregulation of the autophagy marker LC3 both at the mRNA and protein levels. Significantly, while hMECs expressing Ecd or mutant Ras alone did not form tumors in NOD/SCID mice, Ecd+Ras-overexpressing hMECs formed tumors, clearly demonstrating oncogenic cooperation between Ecd and mutant Ras. Collectively, we demonstrate an important co-oncogenic role of Ecd in the progression of mammary oncogenesis through promoting cell survival.