cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.13346595.v1
title: Additional file 2 of Proteomic signatures of 16 major types of human cancer reveal universal and cancer-type-specific proteins for the identification of potential therapeutic targets

description: Additional file 2: Table S1. Patients’ clinical characteristics and replications for data quality control related to Fig. 1 and Figure S1.
DOI: 10.6084/m9.figshare.14285265
title: ISOKINETIC RESPONSE, VISCOSUPPLEMENTATION AND STRENGTH TRAINING IN GONARTHROSIS

description: ABSTRACT Introduction Viscosupplementation and strength training are proposed interventions in the treatment of knee osteoarthritis. Objective To describe the isokinetic response in women with knee osteoarthritis who underwent both interventions. Methods A double-blind, randomized clinical trial involving thirty women diagnosed with grade II and III bilateral knee osteoarthritis using the radiological criteria of Kellgren & Lawrence. The subjects were randomized into three groups of ten patients each: one group was submitted to viscosupplementation and strength training (VST), another was submitted to strength training (ST) only, and a third to viscosupplementation (VS) only. All evaluations followed the study phases defined as pre-procedure (PRE); after 48 hours of VS (POS-VS); after 12 weeks of training (POS T); and after eight weeks of detraining (POS D). Intra-articular knee infiltrations were performed with a single dose of Hylan GF-20 and isokinetic dynamometry to determine the maximum torque in knee extension and flexion. Pain was measured by the visual analogue scale (VAS). Results The interventions promoted improvements in the isokinetic response in all three groups and in both muscle groups, with advantage for the extensor group. A significant difference was noticed in the isokinetic response of the trained groups when compared only to the viscosupplemented group (p&lt;0.005), and the VST group showed better isokinetic response compared to the ST group. Conclusion Combined treatment with viscosupplementation and strength training, and treatment with strength training only, presented better results in terms of isokinetic response and pain reduction than viscosupplementation alone. Level of evidence I; Therapeutic studies-Investigating the results of treatment.
DOI: 10.6084/m9.figshare.14285269
title: RESISTANCE TRANING PROTOCOLS PROMOTE STRENGTH INCREASE WITHOUT MORPHOLOGICAL CHANGES

description: ABSTRACT Introduction Resistance training (RT) has been related to increased protein synthesis, and in the myocardium it triggers morphological adaptations that result in improved cardiac contractility. In skeletal muscle, RT promotes an improvement in functional capacity and in sarcopenia caused by aging. However, the efficacy of this training method in the cardiac and skeletal systems has not yet been clarified. Objective To investigate the effect of different vertical ladder RT protocols on cardiac and skeletal structure and morphology. Materials and Methods: Wistar rats (n = 28) were randomized into four groups: sedentary (C); RT protocol with 4 to 9 climbs, 3 sessions/week, 120 second interval and intensity of 50% to 100% of the maximum load (ML) with progressive addition of 30 g (RT1); RT protocol with 4 to 5 climbs, 3 sessions/week, 60 second interval and intensity of 50% to 100% of the ML, where a 30 g overload was added in the 5th climb (RT2); RT protocol with 4 to 5 climbs, 5 sessions/week, 60 second interval and intensity of 50% to 100% of the ML; the animals that completed the 4th climb underwent the 5th climb with 100% ML plus 30 g (RT3). RT protocols were performed for 9 weeks with a duration of 30 to 45 minutes/day. The nutritional profile and cardiac/skeletal muscle morphology were evaluated along with the cross sectional area and collagen fraction. Results RT did not promote adaptations in cardiac and musculoskeletal structure and morphology, nor was it able to reduce body weight and body fat deposits. However, RT brought about an increase in absolute and relative strength. Conclusion Vertical ladder RT protocols, regardless of weekly frequency, lead to increased muscle strength without cardiac and skeletal structural adaptations. Level of evidence I, Therapeutic studies - Investigating treatment results.
DOI: 10.6084/m9.figshare.14285267
title: CORTISOL AND SEROTONIN LEVELS IN SCHIZOPHRENIC INPATIENTS UNDERGOING AEROBIC TRAINING

description: ABSTRACT Introduction Individuals with schizophrenia tend to have high levels of cortisol and changes in the serotonergic mechanism. However, the effects of aerobic exercises on cortisol and serotonin levels in schizophrenic inpatients are not well established. Objective To evaluate the effects of an aerobic training program on serotonin and cortisol levels in schizophrenic inpatients. Methods Thirty schizophrenic subjects were randomly assigned to an exercise group (EG; n = 15; age: 29 ± 9.08 years; BMI: 23.57 ± 4.33 kg/m2) or a control group (CG; n = 15; age: 33.17 ± 12.8 years; BMI: 22.89 ± 5.68 kg/m2). EG performed an aerobic training program in a cycle ergometer (57% to 67% of the maximum heart rate) for 30 minutes, five days a week, with a total of twenty sessions. The analysis of cortisol (Chemiluminescence Method) and serotonin (High Performance Liquid Chromatography) was performed before and after testing in both groups. The level of significance was of p&lt;0.05. Results After the exercise sessions, EG showed a significant reduction in cortisol levels (Δ = -5.68 mcg/dl%, p &lt; 0.0001) and a significant increase in serotonin levels (Δ = 47.63 ng/ml, p = 0.015) compared to CG. Conclusion The aerobic training program was effective in reducing cortisol levels and increasing serotonin levels in schizophrenic inpatients. Level of evidence I; Randomized clinical trial.
DOI: 10.6084/m9.figshare.14285267.v1
title: CORTISOL AND SEROTONIN LEVELS IN SCHIZOPHRENIC INPATIENTS UNDERGOING AEROBIC TRAINING

description: ABSTRACT Introduction Individuals with schizophrenia tend to have high levels of cortisol and changes in the serotonergic mechanism. However, the effects of aerobic exercises on cortisol and serotonin levels in schizophrenic inpatients are not well established. Objective To evaluate the effects of an aerobic training program on serotonin and cortisol levels in schizophrenic inpatients. Methods Thirty schizophrenic subjects were randomly assigned to an exercise group (EG; n = 15; age: 29 ± 9.08 years; BMI: 23.57 ± 4.33 kg/m2) or a control group (CG; n = 15; age: 33.17 ± 12.8 years; BMI: 22.89 ± 5.68 kg/m2). EG performed an aerobic training program in a cycle ergometer (57% to 67% of the maximum heart rate) for 30 minutes, five days a week, with a total of twenty sessions. The analysis of cortisol (Chemiluminescence Method) and serotonin (High Performance Liquid Chromatography) was performed before and after testing in both groups. The level of significance was of p&lt;0.05. Results After the exercise sessions, EG showed a significant reduction in cortisol levels (Δ = -5.68 mcg/dl%, p &lt; 0.0001) and a significant increase in serotonin levels (Δ = 47.63 ng/ml, p = 0.015) compared to CG. Conclusion The aerobic training program was effective in reducing cortisol levels and increasing serotonin levels in schizophrenic inpatients. Level of evidence I; Randomized clinical trial.
DOI: 10.6084/m9.figshare.14285268
title: AUTONOMIC, CARDIOVASCULAR & PHYSIOLOGICAL RESPONSES IN STRENGTH TRAINING PROTOCOLS

description: ABSTRACT Introduction Strength training is a recurrent practice among several publics and the topic of several studies, yet there is a shortage of previous studies that analyzed these parameters in the same subjects in training sessions involving volume, interval and different repetitions maximum ranges. Objective The study was aimed at measuring and comparing the acute effect of different ST (strength training) protocols on HR (heart rate), HRV (heart rate variability), [LAC] (lactate concentration), [CK] (creatine kinase) and SPE (subjective perceived exertion). Methods Eleven individuals with previous experience were recruited and in three sessions they performed three different training models, namely: high load (4 sets at 90% of 1RM, 180s rest between sets), medium load (3 sets at 75% of 1 RM, 90s rest between sets), and low load (2 sets at 50% of 1 RM, 45s rest between sets) in free squat, bench press, deadlift and bent-over row exercises. Results There was no difference in CK between low load (resistance) and medium load (hypertrophy) (p = 0.60), between resistance and high load (strength) (p = 0.84), and between hypertrophy and strength (p = 0.91), while there was higher lactate accumulation in training with medium and low loads in comparison to training with high loads (p &lt;0.001). Conclusion It can be noted that workouts with high loads, few repetitions and longer intervals (maximum strength) generate lower blood lactate concentrations and SPE values when compared to training with lower loads and shorter intervals (resistance training and hypertrophy). Additionally, when evaluating autonomic and cardiovascular variables, it would appear that manipulating the percentage of 1RM and the interval time does not generate significant changes in HRV, blood pressure (BP) and HR when the repetitions are executed until failure. Level of evidence II; Prospective comparative study.
DOI: 10.6084/m9.figshare.14285269.v1
title: RESISTANCE TRANING PROTOCOLS PROMOTE STRENGTH INCREASE WITHOUT MORPHOLOGICAL CHANGES

description: ABSTRACT Introduction Resistance training (RT) has been related to increased protein synthesis, and in the myocardium it triggers morphological adaptations that result in improved cardiac contractility. In skeletal muscle, RT promotes an improvement in functional capacity and in sarcopenia caused by aging. However, the efficacy of this training method in the cardiac and skeletal systems has not yet been clarified. Objective To investigate the effect of different vertical ladder RT protocols on cardiac and skeletal structure and morphology. Materials and Methods: Wistar rats (n = 28) were randomized into four groups: sedentary (C); RT protocol with 4 to 9 climbs, 3 sessions/week, 120 second interval and intensity of 50% to 100% of the maximum load (ML) with progressive addition of 30 g (RT1); RT protocol with 4 to 5 climbs, 3 sessions/week, 60 second interval and intensity of 50% to 100% of the ML, where a 30 g overload was added in the 5th climb (RT2); RT protocol with 4 to 5 climbs, 5 sessions/week, 60 second interval and intensity of 50% to 100% of the ML; the animals that completed the 4th climb underwent the 5th climb with 100% ML plus 30 g (RT3). RT protocols were performed for 9 weeks with a duration of 30 to 45 minutes/day. The nutritional profile and cardiac/skeletal muscle morphology were evaluated along with the cross sectional area and collagen fraction. Results RT did not promote adaptations in cardiac and musculoskeletal structure and morphology, nor was it able to reduce body weight and body fat deposits. However, RT brought about an increase in absolute and relative strength. Conclusion Vertical ladder RT protocols, regardless of weekly frequency, lead to increased muscle strength without cardiac and skeletal structural adaptations. Level of evidence I, Therapeutic studies - Investigating treatment results.
DOI: 10.6084/m9.figshare.14285271
title: SPORTS PARTICIPATION ASSOCIATED WITH HEALTH RISK BEHAVIORS IN ADOLESCENT ATHLETES

description: ABSTRACT Introduction Participation in structured sports activities is essential for the health of adolescents, since adolescence is a period in which several physical, psychological, cognitive and social changes occur, where the sense of autonomy in decision-making may prompt them to adhere to certain health risk behaviors. Objective To verify the association of sports participation with health risk behaviors in adolescent athletes. Methods A cross-sectional study with 367 athletes (15.68 ± 0.78 years) from Curitiba/PR (state of Paraná). Associated factors and health risk behaviors (HRB) were assessed using questionnaires. Poisson regression with robust variance was used to analyze factors associated with HRB, adopting p &lt;0.05. Results Team sport was positively associated with longer TV viewing time (PR: 3.11; 95% CI: 1.13-8.58). Years of participation were positively associated with longer TV viewing (PR: 1.14, 95% CI: 1.01-1.29) and video game playing time (PR: 1.12, 95% CI: 1.01-1.25). Negative associations were found for weekly training volume in longer video game playing time (OR: 0.92, 95% CI: 0.86-0.99), low vegetable consumption (PR: 0.98, 95% CI: 0.96-0.99), and in light (PR: 0.95, 95%CI: 0.92-0.99) and excessive (PR: 0.94, 95%CI: 0.89-0.99) alcoholic consumption. Conclusion The weekly training volume favors a reduction in video game playing time, lower alcohol consumption, and increased vegetable consumption in adolescent athletes. Level of Evidence III; Diagnostic studies - Investigation of a diagnostic test; Study of non-consecutive patients, without a “gold standard” applied uniformly.
DOI: 10.6084/m9.figshare.14285268.v1
title: AUTONOMIC, CARDIOVASCULAR & PHYSIOLOGICAL RESPONSES IN STRENGTH TRAINING PROTOCOLS

description: ABSTRACT Introduction Strength training is a recurrent practice among several publics and the topic of several studies, yet there is a shortage of previous studies that analyzed these parameters in the same subjects in training sessions involving volume, interval and different repetitions maximum ranges. Objective The study was aimed at measuring and comparing the acute effect of different ST (strength training) protocols on HR (heart rate), HRV (heart rate variability), [LAC] (lactate concentration), [CK] (creatine kinase) and SPE (subjective perceived exertion). Methods Eleven individuals with previous experience were recruited and in three sessions they performed three different training models, namely: high load (4 sets at 90% of 1RM, 180s rest between sets), medium load (3 sets at 75% of 1 RM, 90s rest between sets), and low load (2 sets at 50% of 1 RM, 45s rest between sets) in free squat, bench press, deadlift and bent-over row exercises. Results There was no difference in CK between low load (resistance) and medium load (hypertrophy) (p = 0.60), between resistance and high load (strength) (p = 0.84), and between hypertrophy and strength (p = 0.91), while there was higher lactate accumulation in training with medium and low loads in comparison to training with high loads (p &lt;0.001). Conclusion It can be noted that workouts with high loads, few repetitions and longer intervals (maximum strength) generate lower blood lactate concentrations and SPE values when compared to training with lower loads and shorter intervals (resistance training and hypertrophy). Additionally, when evaluating autonomic and cardiovascular variables, it would appear that manipulating the percentage of 1RM and the interval time does not generate significant changes in HRV, blood pressure (BP) and HR when the repetitions are executed until failure. Level of evidence II; Prospective comparative study.
DOI: 10.6084/m9.figshare.14285275
title: RESPONSES OF PLASMA ADIPOKINES TO HIGH INTENSITY INTERVAL TRAINING: SYSTEMATIC REVIEW

description: ABSTRACT Introduction Obesity is one of the major diseases of modern times. However, the explanation for its pathophysiology is recent and has not yet been fully elucidated. White adipose tissue synthesizes and secretes adipokines that affect several pathologies related to obesity. Excessive growth of this tissue results in increased levels of pro-inflammatory adipokines and a consequent decrease in anti-inflammatory adipokines. Nevertheless, most studies use moderate intensity training, limiting the understanding of high intensity interval training in these proteins. Objective To verify the latest information on the effects of HIIT in improving the profile of circulating adipokines. Methods A search was performed on the databases PUBMED, Lilacs, HighWire, BVS and the Cochrane Database of Systematic Reviews, with the following keywords: HIIT adipokines, HIIT leptin, HIIT adiponectin. Eleven studies were selected, published in English and Portuguese between 2013 and 2017. Results HIIT proved to be effective in increasing adiponectin in the adolescent population and in Olympic athletes, but this depended on a good prescription parameter and exercise intensity. However, maximum or supramaximal intensities were superior to low and moderate intensities. In turn, leptin presented a significant decrease in response to HIIT due to the reduction of adipose tissue, demonstrating a directly proportional relation. Other adipokines, such as omentin-1 and interleukin-10, also responded positively to HIIT, resulting in improved anti-inflammatory status. Conclusion HIIT proved to be an efficient method to reduce inflammation due to obesity, as well as inducing an improvement in sports performance. However, the effects depend on training volume, intensity and prescription method. Level of evidence I; Therapeutic study–Investigating the results of treatment.
DOI: 10.6084/m9.figshare.14285273
title: THE EFFECT OF COLD WATER IMMERSION ON PAIN, MUSCLE RECRUITMENT AND POSTURAL CONTROL IN ATHLETES

description: ABSTRACT Introduction Numerous recovery strategies have been used to minimize performance loss related to delayed onset muscle soreness in athletes, and are part of prevention programs and training of most high-level sports. Objective To analyze the effects of cold-water immersion on delayed-onset muscle soreness, muscle recruitment, and postural control in soccer players. Objective The maximum load of the quadriceps femoris muscle strength was determined. After three days, the pain scale was used to measure the subject’s pain intensity. The recruitment of the quadriceps muscle was determined at the moment of the kick, and was associated with postural control. Methods Randomized, blinded clinical trial study. Two repeated series of maximum load sets at 60% MVC, performed in a knee extension chair, were used to induce quadriceps fatigue in the athletes. Participants Twenty-eight soccer players were allocated to four intervention groups: cold water immersion (CWIG, n = 7), thermoneutral water immersion (TWIG, n = 7), active recovery (ARG, n = 7), and rest (RG, n = 7), with each intervention being carried out for ten minutes. Revaluations were carried out after 24, 48, and 72 hours of the fatigue protocol. Results Pain intensity in the CWIG returned to baseline after 72 hours, while the TWIG, ARG, and RG continued to feel greater pain. For the other outcomes, no differences were found between the groups. Conclusion With regard to muscle recruitment and postural control at the time of the kick, no significant differences were found for the time periods or intervention established. Level of evidence I; High-quality randomized clinical trial with or without statistically significant difference, but with narrow confidence intervals.
DOI: 10.6084/m9.figshare.14285274
title: REFERENCE VALUES FOR BALANCE IN PHYSICALLY ACTIVE ELDERLY WOMEN

description: ABSTRACT Introduction Body balance is one of the most important factors related to falls, quality of life, and independence, and its evaluation is therefore important. Objective To establish reference values for balance tests in physically active older women from different age groups. Methods The sample consisted of 192 physically active women aged 60 to 79 years who were submitted to the following tests: timed up and go (TUG), one-leg stand (OLS), five-repetition chair stand (CS-5), functional reach (FR), and tandem stand test (TST). Descriptive statistics (percentile analysis) and the Mann-Whitney U test were used. Results In older women aged 60 to 69 years, the values indicating “good” balance were a score less than 5.7 s in the TUG, achieving 30 s of OLS, performing the CS-5 test in less than 8.5 s, and a result greater than 35.5 cm in the FR test. In older women aged 70 to 79 years, the values indicating “good” balance were a score less than 5.9 s in the TUG, achieving 30 s of OLS, performing the CS-5 in less than 8.5 s, and a result greater than 33 cm in the FR test. In the TST, most of the physically active subjects achieved the ceiling performance. Conclusion The reference values obtained are similar to or better than those reported in the literature. The use of the TST is not recommended for physically active older women because of its low discriminatory power in this group. Level of evidence III; Study of non consecutive patients; without consistently applied reference ‘‘gold’’ standard.
DOI: 10.6084/m9.figshare.14285275.v1
title: RESPONSES OF PLASMA ADIPOKINES TO HIGH INTENSITY INTERVAL TRAINING: SYSTEMATIC REVIEW

description: ABSTRACT Introduction Obesity is one of the major diseases of modern times. However, the explanation for its pathophysiology is recent and has not yet been fully elucidated. White adipose tissue synthesizes and secretes adipokines that affect several pathologies related to obesity. Excessive growth of this tissue results in increased levels of pro-inflammatory adipokines and a consequent decrease in anti-inflammatory adipokines. Nevertheless, most studies use moderate intensity training, limiting the understanding of high intensity interval training in these proteins. Objective To verify the latest information on the effects of HIIT in improving the profile of circulating adipokines. Methods A search was performed on the databases PUBMED, Lilacs, HighWire, BVS and the Cochrane Database of Systematic Reviews, with the following keywords: HIIT adipokines, HIIT leptin, HIIT adiponectin. Eleven studies were selected, published in English and Portuguese between 2013 and 2017. Results HIIT proved to be effective in increasing adiponectin in the adolescent population and in Olympic athletes, but this depended on a good prescription parameter and exercise intensity. However, maximum or supramaximal intensities were superior to low and moderate intensities. In turn, leptin presented a significant decrease in response to HIIT due to the reduction of adipose tissue, demonstrating a directly proportional relation. Other adipokines, such as omentin-1 and interleukin-10, also responded positively to HIIT, resulting in improved anti-inflammatory status. Conclusion HIIT proved to be an efficient method to reduce inflammation due to obesity, as well as inducing an improvement in sports performance. However, the effects depend on training volume, intensity and prescription method. Level of evidence I; Therapeutic study–Investigating the results of treatment.