cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.48530/isoarch.2022.003.v1
title: Carbon, nitrogen and sulphur isotope data of archaeological fish and mammal bone collagen from Lithuania

description: Until relatively recently, stable sulphur isotope analysis of bone collagen was seldom undertaken in bioarchaeological research. With increasing frequency, its application has proven useful in reconstructing palaeodiets and palaeoecologies, as well as identifying potential migration and mobility patterns. Here, sulphur (δ34S) isotope analysis, together with carbon (δ13C) and nitrogen (δ15N), was performed on six fish and 34 mammal bone collagen samples from 14 prehistoric sites in Lithuania dating from the Late Mesolithic (ca. 7000–5000 cal BC) to the Late Bronze Age (ca. 1100–500 cal BC). We present the first δ34S data from Lithuania, including coupled δ13C and δ15N data, offering a crucial dataset for future research to explore spatial and temporal variability in the region and beyond.
DOI: 10.5067/grgac-20g06
title: GRACE NON-TIDAL ATMOSPHERE AND OCEAN GEOPOTENTIAL COEFFICIENTS GFZ RELEASE 6.0 GAC
DOI: 10.5067/grgac-20j06
title: GRACE NON-TIDAL ATMOSPHERE AND OCEAN GEOPOTENTIAL COEFFICIENTS JPL RELEASE 6.0 GAC
DOI: 10.5067/grgad-20c06
title: GRACE OCEAN BOTTOM GEOPOTENTIAL COEFFICIENTS CSR RELEASE 6.0 GAD
DOI: 10.5067/grgad-20g06
title: GRACE OCEAN BOTTOM GEOPOTENTIAL COEFFICIENTS GFZ RELEASE 6.0 GAD
DOI: 10.15468/dl.zdxvtf
title: Occurrence Download

description: A dataset containing 25023 species occurrences available in GBIF matching the query:
{
 "DatasetKey" : [
 "is Herbarium of the French Institute of Pondicherry"
 ]
}

 The dataset includes 25023 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0004138-260126135527185/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.5067/grgad-20j06
title: GRACE OCEAN BOTTOM GEOPOTENTIAL COEFFICIENTS JPL RELEASE 6.0 GAD
DOI: 10.5067/grgsm-20c06
title: GRACE STATIC FIELD GEOPOTENTIAL COEFFICIENTS CSR RELEASE 6.0
DOI: 10.5067/grgia-05j10
title: TELLUS GRACE Level-3 0.5-degree Glacial Isostatic Adjustment v1.0 datasets produced by JPL
DOI: 10.15468/dl.hmcj6f
title: Occurrence Download

description: A dataset containing 16 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Continent is Asia",
 "TaxonKey is Cryptocoryne wendtii"
 ]
}

 The dataset includes 16 records from 5 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0006494-260129131611470/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.um32qp
title: Occurrence Download

description: A dataset containing 3319732 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is Türkiye",
 "DatasetKey is EOD – eBird Observation Dataset"
 ]
}

 The dataset includes 3319732 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0006487-260129131611470/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.p7wds9
title: Occurrence Download

description: A dataset containing 561 species occurrences available in GBIF matching the query:
{
 "and" : [
 "DatasetKey is KSA Flora Survey 2013",
 "TaxonKey is Nepeta deflersiana"
 ]
}

 The dataset includes 561 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0006495-260129131611470/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.xs5wuw
title: Occurrence Download

description: A dataset containing 219 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Dilodendron costaricense",
 "HasCoordinate is true",
 "BasisOfRecord is one of (Specimen)"
 ]
}

 The dataset includes 219 records from 29 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0006496-260129131611470/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.14278/rodare.4471
title: Ultrafast X-ray CT data of air void distribution in fresh concrete for different concrete compositions

description: This data set includes reconstructed image sequences from ultrafast X-ray CT scans of fresh concrete with different compositions before and after compaction of 30 s on a vibration table. The scans of the concrete samples were performed with a speed of 50 mm/s in vertical direction. The properties of the different compositions are given in the Excel file.
DOI: 10.14278/rodare.4470
title: Ultrafast X-ray CT data of air void distribution in fresh concrete for different concrete compositions

description: This data set includes reconstructed image sequences from ultrafast X-ray CT scans of fresh concrete with different compositions before and after compaction of 30 s on a vibration table. The scans of the concrete samples were performed with a speed of 50 mm/s in vertical direction. The properties of the different compositions are given in the Excel file.
DOI: 10.3886/e244845
title: 08122868281 Gregory University 2026/27 Direct Entry/Transfer Application/Admission Form

description: 08122868281 Gregory University 2026/27 Direct Entry/Transfer Application/Admission Form call(08122868281)(+2348122868281 IS STILL ON SALE . Call the school admin office [DR MRS Maryan Adeyemo] Predegree/Part Time Form/Conversion form on (08122868281)(+2348122868281] For HND in Community Health Extension Workers (CHEWs), Junior Community Health Extension Workers (JCHEWs), environmental health officers (EH medical technicians (MT) and records clerks (RC).08122868281 Gregory University 2026/27 Direct Entry/Transfer Application/Admission Form call(08122868281)(+2348122868281 IS STILL ON SALE . Call the school admin office [DR MRS Maryan Adeyemo] Predegree/Part Time Form/Conversion form on (08122868281)(+2348122868281] For HND in Community Health Extension Workers (CHEWs), Junior Community Health Extension Workers (JCHEWs), environmental health officers (EH medical technicians (MT) and records clerks (RC).
DOI: 10.6084/m9.figshare.31228323
title: Single-cell transcriptomics and machine-learning reveal M1 macrophage-driven progression from minimal change disease to focal segmental glomerulosclerosis

description: Minimal change disease (MCD) and focal segmental glomerulosclerosis (FSGS) are two key nephrotic syndrome types with significant clinical implications. MCD predominantly affects children, while FSGS is more common in adults, often leading to irreversible kidney dysfunction. Despite shared features like podocyte injury and immune dysregulation, their pathological and clinical presentations differ. Understanding gene expression changes in these diseases could reveal new therapeutic targets. Single-cell transcriptomic datasets (GSE213030 and GSE176465) were analyzed to investigate cellular interactions in MCD and FSGS. Machine learning algorithms developed diagnostic models, and immune subtypes were identified for detailed subtype analysis. Key genes were validated using qRT-PCR and immunohistochemical staining in a mouse model, focusing on their association with M1 macrophage activation. Integrated single-cell analysis identified six key genes (<i>PTPRC</i>, <i>ACTR2</i>, <i>MYO1F</i>, <i>UBB</i>, <i>CSF1R</i>, and <i>LYN</i>) central to macrophage activation. These genes were closely linked to M1 macrophage activation, as confirmed through transcriptomic profiling and spatial co-expression patterns in Sprague–Dawley (SD) rat models. Machine learning models validated their predictive value in disease progression from MCD to FSGS. This study highlights six hub genes as potential biomarkers for predicting MCD-to-FSGS progression. Their roles in macrophage activation suggest these genes may serve as novel therapeutic targets for personalized treatment strategies, particularly for patients at high risk of disease transition. Overview of the integrative analysis and validation workflow. Part of the picture is taken from GDP by Figdraw.
DOI: 10.6084/m9.figshare.31228323.v1
title: Single-cell transcriptomics and machine-learning reveal M1 macrophage-driven progression from minimal change disease to focal segmental glomerulosclerosis

description: Minimal change disease (MCD) and focal segmental glomerulosclerosis (FSGS) are two key nephrotic syndrome types with significant clinical implications. MCD predominantly affects children, while FSGS is more common in adults, often leading to irreversible kidney dysfunction. Despite shared features like podocyte injury and immune dysregulation, their pathological and clinical presentations differ. Understanding gene expression changes in these diseases could reveal new therapeutic targets. Single-cell transcriptomic datasets (GSE213030 and GSE176465) were analyzed to investigate cellular interactions in MCD and FSGS. Machine learning algorithms developed diagnostic models, and immune subtypes were identified for detailed subtype analysis. Key genes were validated using qRT-PCR and immunohistochemical staining in a mouse model, focusing on their association with M1 macrophage activation. Integrated single-cell analysis identified six key genes (<i>PTPRC</i>, <i>ACTR2</i>, <i>MYO1F</i>, <i>UBB</i>, <i>CSF1R</i>, and <i>LYN</i>) central to macrophage activation. These genes were closely linked to M1 macrophage activation, as confirmed through transcriptomic profiling and spatial co-expression patterns in Sprague–Dawley (SD) rat models. Machine learning models validated their predictive value in disease progression from MCD to FSGS. This study highlights six hub genes as potential biomarkers for predicting MCD-to-FSGS progression. Their roles in macrophage activation suggest these genes may serve as novel therapeutic targets for personalized treatment strategies, particularly for patients at high risk of disease transition. Overview of the integrative analysis and validation workflow. Part of the picture is taken from GDP by Figdraw.
DOI: 10.15468/dl.sm6dsb
title: Occurrence Download

description: A dataset containing 20869 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (, , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , Alternanthera philoxeroides, , , , , , , , , , , Lispe setuligera, , , , , , Mogiphanes philoxeroides, , Terniopsis yongtaiensis, , Alternanthera ebracteolata, , Phenrica littoralis, Hydrophylita neusae, , , Altica gravida, Bucholzia philoxeroides, Celosia amphibia, , , , , Achyranthes philoxeroides, Mogiphanes philorexoides, , Brandesia martiana, , , , , , , , , , , Alternanthera aphylla, , Alternanthera philoxerina, , , , , , Brandesia martiana, , , , , , , , Achyranthes paludosa, , , , , , , , , , , Achyranthes aphylla, , , , , , Celosia amphibia, , , , , , , , , , , Telanthera philoxeroides, , , , , )",
 "BasisOfRecord is one of (Specimen, Human Observation, Observation, Living Specimen, Machine Observation, Literature Occurrence)",
 "Geometry POLYGON((-180 -90,180 -90,180 90,-180 90,-180 -90))",
 "HasCoordinate is true",
 "HasGeospatialIssue is false"
 ]
}

 The dataset includes 20869 records from 305 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0006497-260129131611470/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.6084/m9.figshare.30847347
title: Advances in the applications of stimulus-responsive nanomedicines for anti-cancer therapy

description: Current major cancer therapies are limited by nonspecific drug distribution and severe off-target toxicity. Nanomedicine has emerged as a promising strategy for targeted tumor drug delivery, leveraging nanoparticles’ unique properties to enhance drug solubility, extend circulation, and enable imaging, while relying on the enhanced permeability and retention (EPR) effect and antibody/ligand recognition for passive and active targeting to accumulate at tumor sites. Stimulus-responsive nanomedicines are another trend accompanying both targeting strategies to address further issues of tissue penetration, cellular internalization, and drug release that are critical for the payload’s therapeutic efficacy, they exploit the internal tumor microenvironment (TME)-specific features of pH, glutathione (GSH), Reactive oxygen species (ROS), Enzymes, and adenosine triphosphate (ATP) that are differential from normal tissues or externally introduced triggers of light, magnetic fields, ultrasound to release the therapeutic modality via a spatiotemporally controlled manner to overcome encountered barriers and enable optimal therapeutic efficacy. This review will summarize recent advances in the application of these stimulus-responsive nanomedicines in cancer therapy, focusing on their functions of achieving targeted release, improved tumor penetration, maximum efficacy, multidrug resistance reversal, TME modulation, and synergistic combination therapies. It also discusses current challenges and future directions for facilitating stimulus-responsive nanomedicines.
DOI: 10.6084/m9.figshare.30847347.v1
title: Advances in the applications of stimulus-responsive nanomedicines for anti-cancer therapy

description: Current major cancer therapies are limited by nonspecific drug distribution and severe off-target toxicity. Nanomedicine has emerged as a promising strategy for targeted tumor drug delivery, leveraging nanoparticles’ unique properties to enhance drug solubility, extend circulation, and enable imaging, while relying on the enhanced permeability and retention (EPR) effect and antibody/ligand recognition for passive and active targeting to accumulate at tumor sites. Stimulus-responsive nanomedicines are another trend accompanying both targeting strategies to address further issues of tissue penetration, cellular internalization, and drug release that are critical for the payload’s therapeutic efficacy, they exploit the internal tumor microenvironment (TME)-specific features of pH, glutathione (GSH), Reactive oxygen species (ROS), Enzymes, and adenosine triphosphate (ATP) that are differential from normal tissues or externally introduced triggers of light, magnetic fields, ultrasound to release the therapeutic modality via a spatiotemporally controlled manner to overcome encountered barriers and enable optimal therapeutic efficacy. This review will summarize recent advances in the application of these stimulus-responsive nanomedicines in cancer therapy, focusing on their functions of achieving targeted release, improved tumor penetration, maximum efficacy, multidrug resistance reversal, TME modulation, and synergistic combination therapies. It also discusses current challenges and future directions for facilitating stimulus-responsive nanomedicines.
DOI: 10.6084/m9.figshare.31113125
title: An AlFu MOF nanoadjuvant functionalized with mannose for potential dendritic-cell targeting and dual TLR9–STING activation

description: Aluminum adjuvants remain the most widely used adjuvants in licensed vaccines. Their broader application, however, is restricted by local and systemic adverse effects and limited antigen compatibility, slowing vaccine development. A nanoscale aluminum – fumarate metal – organic framework (AlFu‑MOF) was synthesized in water using Pluronic F127 and acetic acid. Based on this framework, a composite nanoadjuvant—(D)-mannose‑cTAT‑CpG@M@AlFu‑MOF (DCC@M@AlFu‑MOF) – was designed and characterized. The loading capacity for immunostimulatory cargos, including MSA‑2, CpG, cTAT, (D)-mannose, and OVA, was evaluated. Cellular uptake and immune activation of antigen‑presenting cells were tested <i>in vitro</i>. AlFu‑MOF displayed high loading efficiency and improved antigen availability. DCC@M@AlFu‑MOF promoted dendritic cell maturation and activation and also triggered the STING signaling pathway. DCC@M@AlFu‑MOF is an aluminum‑based nanoadjuvant with potential dendritic cell‑targeting ability. It can coordinate innate immune signaling and shows promise for enhancing vaccine‑induced immune responses.
DOI: 10.6084/m9.figshare.31113125.v1
title: An AlFu MOF nanoadjuvant functionalized with mannose for potential dendritic-cell targeting and dual TLR9–STING activation

description: Aluminum adjuvants remain the most widely used adjuvants in licensed vaccines. Their broader application, however, is restricted by local and systemic adverse effects and limited antigen compatibility, slowing vaccine development. A nanoscale aluminum – fumarate metal – organic framework (AlFu‑MOF) was synthesized in water using Pluronic F127 and acetic acid. Based on this framework, a composite nanoadjuvant—(D)-mannose‑cTAT‑CpG@M@AlFu‑MOF (DCC@M@AlFu‑MOF) – was designed and characterized. The loading capacity for immunostimulatory cargos, including MSA‑2, CpG, cTAT, (D)-mannose, and OVA, was evaluated. Cellular uptake and immune activation of antigen‑presenting cells were tested <i>in vitro</i>. AlFu‑MOF displayed high loading efficiency and improved antigen availability. DCC@M@AlFu‑MOF promoted dendritic cell maturation and activation and also triggered the STING signaling pathway. DCC@M@AlFu‑MOF is an aluminum‑based nanoadjuvant with potential dendritic cell‑targeting ability. It can coordinate innate immune signaling and shows promise for enhancing vaccine‑induced immune responses.
DOI: 10.6084/m9.figshare.31046585
title: Antibacterial efficacy and adaptive proteomic strategies of antibiotic-resistant pathogens on nanostructured copper surfaces

description: To evaluate the antibacterial activity of nanostructured copper oxide surfaces synthesized by hot water treatment (HWT) and to elucidate the underlying mechanisms of copper-induced stress responses in antibiotic-resistant Citrobacter freundii CF51 and Staphylococcus aureus HAR12. Copper sheets were subjected to HWT to generate Cu<sub>2</sub>O/CuO nanostructures. Antibacterial and antibiofilm activities were assessed using viability and biofilm assays. Cellular morphology was examined by FESEM. Whole-proteome and KEGG pathway analyses were performed to identify bacterial adaptive responses. Nanostructured copper rapidly inactivated C. freundii and eliminated S. aureus with longer exposure. FESEM imaging showed membrane disruption, deformation, and lysis, with more severe damage on nanostructured surfaces. Proteomic analysis revealed species-specific regulation of pathways related to energy metabolism, transcription, ion transport, and cell envelope biogenesis. ABC transporters were upregulated in C. freundii but downregulated in S. aureus. The Staphylococcus aureus infection pathway was markedly suppressed. Efflux transporters (CorA, MdtF, YhiI) were consistently upregulated in both species, indicating conserved copper-detoxification mechanisms. Nanostructured copper oxide surfaces demonstrate potent antibacterial and antibiofilm activity and induce distinct proteomic stress responses. These findings support the potential of nanostructured copper as an effective antimicrobial surface against antibiotic-resistant pathogens.
DOI: 10.6084/m9.figshare.31046585.v1
title: Antibacterial efficacy and adaptive proteomic strategies of antibiotic-resistant pathogens on nanostructured copper surfaces

description: To evaluate the antibacterial activity of nanostructured copper oxide surfaces synthesized by hot water treatment (HWT) and to elucidate the underlying mechanisms of copper-induced stress responses in antibiotic-resistant Citrobacter freundii CF51 and Staphylococcus aureus HAR12. Copper sheets were subjected to HWT to generate Cu<sub>2</sub>O/CuO nanostructures. Antibacterial and antibiofilm activities were assessed using viability and biofilm assays. Cellular morphology was examined by FESEM. Whole-proteome and KEGG pathway analyses were performed to identify bacterial adaptive responses. Nanostructured copper rapidly inactivated C. freundii and eliminated S. aureus with longer exposure. FESEM imaging showed membrane disruption, deformation, and lysis, with more severe damage on nanostructured surfaces. Proteomic analysis revealed species-specific regulation of pathways related to energy metabolism, transcription, ion transport, and cell envelope biogenesis. ABC transporters were upregulated in C. freundii but downregulated in S. aureus. The Staphylococcus aureus infection pathway was markedly suppressed. Efflux transporters (CorA, MdtF, YhiI) were consistently upregulated in both species, indicating conserved copper-detoxification mechanisms. Nanostructured copper oxide surfaces demonstrate potent antibacterial and antibiofilm activity and induce distinct proteomic stress responses. These findings support the potential of nanostructured copper as an effective antimicrobial surface against antibiotic-resistant pathogens.
DOI: 10.14469/hpc/15681
title: Quantum crystallography: The structure of [18]-annulene.

description: The structure of [18]annulene (CCDC refcode ANULEN03[cite]10.5517/ccdc.csd.cc2gzmz2[/cite]) was re-refined using modern quantum crystallography (NoSpherA2[cite]10.1107/S0021889808042726[/cite],[cite],[cite]10.1039/d0sc05526c[/cite]). To do this, we used Def2-SVP as the basis set and wB97X-V for the method, with a multiplicity of 2 in the settings for the OLEX2 program.

The published structure has the molecule sitting across a centre of symmetry so only half of it is unique, and it was found to be disordered with a second orientation of the complete molecule (effectively the macrocycle rotated in plane by ca. 30°) in a ca. 84:16 ratio. This caused trouble with the quantum crystallography refinements as allowing all of the hydrogen atoms to be positionally free (i.e. removing the AFIX commands) and anisotropic at the same time caused 6 of the 8 hydrogen atoms of the minor occupancy component to “wander off” into chemically nonsensical positions, and 4 of the major occupancy plus all 8 of the minor occupancy hydrogen atoms went non positive definite (one of the thermal ellipsoid radii refined to a negative length).

However, we discovered that doing the refinement in stages allowed a more settled structure. Starting with the published structure and allowing all of the hydrogen atoms to be positionally free gave a nice stable result. Allowing the hydrogens to go anisotropic afterwards did result in 1 of the major occupancy and all 8 of the minor occupancy hydrogen atoms going non positive definite (n.p.d.), but the positions of the hydrogen atoms remained sensible.

Subsequently reverting all 8 hydrogen atoms of the minor occupancy component to be isotropic resulted in a stable and sensible refinement where the sole non positive definite atom of the major occupancy component corrected itself into being normal (i.e. no longer non positive definite). This is the version of the structure we used for further analysis.