cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.3394639.v123
title: Spontaneous and therapeutic glycosidic accommodation of host and graft in ABO(H)-incompatible transplantation, a hypothesis.

description: In contrast to non-nucleated ABO(H) red cells, which when transfused to a blood group O(H) recipient undergo destruction within minutes, such hyperacute, humoral rejection occurs relatively rare in transplantations of highly nucleated, metabolically active solid organs, and it is extremely rare in liver transplantations (Adams 1991; Della-Guardia et al. 2008). Moreover, a case of transient, selective disappearance of preexisting donor-specific HLA-antibodies after an incompatible liver transplantation, without any rejection episodes, has been reported by Bastiani (2006), and according to Taner et al. (2014)<i> </i>such transient decrease of donor-specific HLA-antibodies is not uncommon after incompatible liver transplantation. In addition, an exponential fall in both anti-A/B reactive IgM and IgG titers were observed after ABO(H) incompatible bone marrow transplantation ((Rowley et al. 2000; Lee et al. 2003). These phenomena most likely reflect a complex mechanism, in which an adsorption of host immunoglobulins on graft epitopes is completed by graft-phenotype-specific glycosylation of these immunoglobulins, and which suggests the targeted use of this mechanism in a hypothetical therapeutic principle.
DOI: 10.6084/m9.figshare.3394639.v124
title: Spontaneous and therapeutic glycosidic accommodation of host and graft in ABO(H)-incompatible transplantation, a hypothesis.

description: In contrast to non-nucleated ABO(H) red cells, which when transfused to a blood group O(H) recipient undergo destruction within minutes, such hyperacute, humoral rejection occurs relatively rare in transplantations of highly nucleated, metabolically active solid organs, and it is extremely rare in liver transplantations (Adams 1991; Della-Guardia et al. 2008). Moreover, a case of transient, selective disappearance of preexisting donor-specific HLA-antibodies after an incompatible liver transplantation, without any rejection episodes, has been reported by Bastiani (2006), and according to Taner et al. (2014)<i> </i>such transient decrease of donor-specific HLA-antibodies is not uncommon after incompatible liver transplantation. In addition, an exponential fall in both anti-A/B reactive IgM and IgG titers were observed after ABO(H) incompatible bone marrow transplantation ((Rowley et al. 2000; Lee et al. 2003). These phenomena most likely reflect a complex mechanism, in which an adsorption of host immunoglobulins on graft epitopes is completed by graft-phenotype-specific glycosylation of these immunoglobulins, and which suggests its targeted use in a hypothetical therapeutic principle.
DOI: 10.6084/m9.figshare.3394639.v125
title: Spontaneous and therapeutic glycosidic accommodation of host and graft in ABO(H)-incompatible transplantation, a hypothesis.

description: In contrast to non-nucleated ABO(H) red cells, which when transfused to a blood group O(H) recipient undergo destruction within minutes, such hyperacute, humoral rejection occurs relatively rare in transplantations of highly nucleated, metabolically active solid organs, and it is extremely rare in liver transplantations (Adams 1991; Della-Guardia et al. 2008). Moreover, a case of transient, selective disappearance of preexisting donor-specific HLA-antibodies after an incompatible liver transplantation, without any rejection episodes, has been reported by Bastiani (2006), and according to Taner et al. (2014)<i> </i>such transient decrease of donor-specific HLA-antibodies is not uncommon after incompatible liver transplantation. In addition, an exponential fall in both anti-A/B reactive IgM and IgG titers were observed after ABO(H) incompatible bone marrow transplantation (Rowley et al. 2000; Lee et al. 2003). These phenomena most likely reflect a complex mechanism, in which adsorption of host immunoglobulins on graft epitopes is completed by graft-phenotype-specific glycosylation of these host immunoglobulins (Arend, 2016; 2016a), and suggests its targeted use in a hypothetical therapeutic principle.
DOI: 10.6084/m9.figshare.3394639.v126
title: Spontaneous and therapeutic glycosidic accommodation of host and graft in ABO(H)-incompatible transplantation, a hypothesis.

description: In contrast to non-nucleated ABO(H) red cells, which when transfused to a blood group O(H) recipient undergo destruction within minutes, such hyperacute, humoral rejection occurs relatively rare in transplantations of highly nucleated, metabolically active solid organs, and it is extremely rare in liver transplantations (Adams 1991; Della-Guardia et al. 2008). Moreover, a case of transient, selective disappearance of preexisting donor-specific HLA-antibodies after an incompatible liver transplantation, without any rejection episodes, has been reported by Bastiani (2006), and according to Taner et al. (2014)<i> </i>such transient decrease of donor-specific HLA-antibodies is not uncommon after incompatible liver transplantation. In addition, an exponential fall in both anti-A/B reactive IgM and IgG titers were observed after ABO(H) incompatible bone marrow transplantation (Rowley et al. 2000; Lee et al. 2003). These phenomena most likely reflect a complex mechanism, in which adsorption of host immunoglobulins on graft epitopes is, based on fucosylation, completed by graft-phenotype-specific glycosylation of these immunoglobulins, and suggest the targeted use of this mechanism in a hypothetical therapeutic principle. <br>
DOI: 10.6084/m9.figshare.3394639.v127
title: Spontaneous and therapeutic glycosidic accommodation of host and graft in ABO(H)-incompatible transplantation, a hypothesis.

description: In contrast to non-nucleated ABO(H) red cells, which when transfused to a blood group O(H) recipient undergo destruction within minutes, such hyperacute, humoral rejection occurs relatively rare in transplantations of highly nucleated, metabolically active solid organs, and it is extremely rare in liver transplantations (Adams 1991; Della-Guardia et al. 2008). Moreover, a case of transient, selective disappearance of preexisting donor-specific HLA-antibodies after an incompatible liver transplantation, without any rejection episodes, has been reported by Bastiani (2006), and according to Taner et al. (2014)<i> </i>such transient decrease of donor-specific HLA-antibodies is not uncommon after incompatible liver transplantation. In addition, an exponential fall in both anti-A/B reactive IgM and IgG titers were observed after ABO(H) incompatible bone marrow transplantation (Rowley et al. 2000; Lee et al. 2003). These phenomena most likely reflect a complex mechanism, in which adsorption of host immunoglobulins on graft epitopes is, based on fucosylation, completed by graft-phenotype-specific glycosylation of these immunoglobulins, and suggest the targeted use of this mechanism in a hypothetical therapeutic principle. <br>
DOI: 10.6084/m9.figshare.3394639.v128
title: Spontaneous and therapeutic glycosidic accommodation of host and graft in ABO(H)-incompatible transplantation, a hypothesis.

description: In contrast to non-nucleated ABO(H) red cells, which when transfused to a blood group O(H) recipient undergo destruction within minutes, such hyperacute, humoral rejection occurs relatively rare in transplantations of highly nucleated, metabolically active solid organs, and it is extremely rare in liver transplantations (Adams 1991; Della-Guardia et al. 2008). Moreover, a case of transient, selective disappearance of preexisting donor-specific HLA-antibodies after an incompatible liver transplantation, without any rejection episodes, has been reported by Bastiani (2006), and according to Taner et al. (2014)<i> </i>such transient decrease of donor-specific HLA-antibodies is not uncommon after incompatible liver transplantation. In addition, an exponential fall in both anti-A/B reactive IgM and IgG titers were observed after ABO(H) incompatible bone marrow transplantation (Rowley et al. 2000; Lee et al. 2003). These phenomena most likely reflect a complex mechanism, in which adsorption of host immunoglobulins on graft epitopes is, based on fucosylation, completed by graft-phenotype-specific glycosylation of host immunoglobulins, and suggest the targeted use of this mechanism in a hypothetical therapeutic principle. <br>
DOI: 10.6084/m9.figshare.3394639.v129
title: Spontaneous and therapeutic glycosidic accommodation of host and graft in ABO(H)-incompatible transplantation, a hypothesis.

description: In contrast to non-nucleated ABO(H) red cells, which when transfused to a blood group O(H) recipient undergo destruction within minutes, such hyperacute, humoral rejection occurs relatively rare in transplantations of highly nucleated, metabolically active solid organs, and it is extremely rare in liver transplantations (Adams 1991; Della-Guardia et al. 2008). Moreover, a case of transient, selective disappearance of preexisting donor-specific HLA-antibodies after an incompatible liver transplantation, without any rejection episodes, has been reported by Bastiani (2006), and according to Taner et al. (2014)<i> </i>such transient decrease of donor-specific HLA-antibodies is not uncommon after incompatible liver transplantation. In addition, an exponential fall in both anti-A/B reactive IgM and IgG titers were observed after ABO(H) incompatible bone marrow transplantation (Rowley et al. 2000; Lee et al. 2003). These phenomena most likely reflect a complex mechanism, in which an adsorption of host immunoglobulins on graft epitopes is completed by their graft-phenotype-specific glycosylation, and suggest the targeted use of this mechanism in a hypothetical therapeutic principle. <br>
DOI: 10.6084/m9.figshare.3394639.v130
title: Spontaneous and therapeutic glycosidic accommodation of host and graft in ABO(H)-incompatible transplantation, a hypothesis.

description: In contrast to non-nucleated ABO(H) red cells, which when transfused to a blood group O(H) recipient undergo destruction within minutes, such hyperacute, humoral rejection occurs relatively rare in transplantations of highly nucleated, metabolically active solid organs, and it is extremely rare in liver transplantations (Adams 1991; Della-Guardia et al. 2008). Moreover, a case of transient, selective disappearance of preexisting donor-specific HLA-antibodies after an incompatible liver transplantation, without any rejection episodes, has been reported by Bastiani (2006), and according to Taner et al. (2014)<i> </i>such transient decrease of donor-specific HLA-antibodies is not uncommon after incompatible liver transplantation. In addition, an exponential fall in both anti-A/B reactive IgM and IgG titers were observed after ABO(H) incompatible bone marrow transplantation (Rowley et al. 2000; Lee et al. 2003). These phenomena most likely reflect a complex mechanism, in which pre-existing anti-graft reactive immunoglobulins are adsorbed on their corresponding graft epitopes and are spontaneously completed by graft-phenotype-specific glycosylation that suggests the targeted use of this mechanism in a hypothetical therapeutic principle. <br>
DOI: 10.6084/m9.figshare.3394639.v131
title: Spontaneous and therapeutic glycosidic accommodation of host and graft in ABO(H)-incompatible transplantation, a hypothesis.

description: In contrast to non-nucleated ABO(H) red cells, which when transfused to a blood group O(H) recipient undergo destruction within minutes, such hyperacute, humoral rejection occurs relatively rare in transplantations of highly nucleated, metabolically active solid organs, and it is extremely rare in liver transplantations (Adams 1991; Della-Guardia et al. 2008). Moreover, a case of transient, selective disappearance of preexisting donor-specific HLA-antibodies after an incompatible liver transplantation, without any rejection episodes, has been reported by Bastiani (2006), and according to Taner et al. (2014)<i> </i>such transient decrease of donor-specific HLA-antibodies is not uncommon after incompatible liver transplantation. In addition, an exponential fall in both anti-A/B reactive IgM and IgG titers were observed after ABO(H) incompatible bone marrow transplantation (Rowley et al. 2000; Lee et al. 2003).These phenomena most likely reflect a complex mechanism, in which pre-existing anti-graft-reactive immunoglobulins are primarily adsorbed on complementary sites on the cell surfaces of the graft, but other than in suspensions of non-nucleated red cells, are spontaneously completed by graft-phenotype-specific glycosylation that suggests the targeted use of this mechanism in a hypothetical therapeutic principle.
DOI: 10.6084/m9.figshare.3394639.v132
title: Spontaneous and therapeutic glycosidic accommodation of host and graft in ABO(H)-incompatible transplantation, a hypothesis.

description: In contrast to non-nucleated ABO(H) red cells, which when transfused to a blood group O(H) recipient undergo destruction within minutes, such hyperacute, humoral rejection occurs relatively rare in transplantations of highly nucleated, metabolically active solid organs, and it is extremely rare in liver transplantations (Adams 1991; Della-Guardia et al. 2008). Moreover, a case of transient, selective disappearance of preexisting donor-specific HLA-antibodies after an incompatible liver transplantation, without any rejection episodes, has been reported by Bastiani (2006), and according to Taner et al. (2014)<i> </i>such transient decrease of donor-specific HLA-antibodies is not uncommon after incompatible liver transplantation. In addition, an exponential fall in both anti-A/B reactive IgM and IgG titers were observed after ABO(H) incompatible bone marrow transplantation (Rowley et al. 2000; Lee et al. 2003). These phenomena most likely reflect a complex mechanism, in which pre-existing anti-graft-reactive immunoglobulins are primarily adsorbed on complementary sites on the cell surfaces of the graft, however, other than at the surfaces of non-nucleated red cells, they are spontaneously completed by graft-phenotype-specific, protective glycosylation that suggests the targeted use of this mechanism in a hypothetical therapeutic principle.
DOI: 10.6084/m9.figshare.3394639.v133
title: Spontaneous and therapeutic glycosidic accommodation of host and graft in ABO(H)-incompatible transplantation, a hypothesis.

description: In contrast to non-nucleated ABO(H) red cells, which when transfused to a blood group O(H) recipient undergo destruction within minutes, such hyperacute, humoral rejection occurs relatively rare in transplantations of highly nucleated, metabolically active solid organs, and it is extremely rare in liver transplantations (Adams 1991; Della-Guardia et al. 2008). Moreover, a case of transient, selective disappearance of preexisting donor-specific HLA-antibodies after an incompatible liver transplantation, without any rejection episodes, has been reported by Bastiani (2006), and according to Taner et al. (2014)<i> </i>such transient decrease of donor-specific HLA-antibodies is not uncommon after incompatible liver transplantation. In addition, an exponential fall in both anti-A/B reactive IgM and IgG titers were observed after ABO(H) incompatible bone marrow transplantation (Rowley et al. 2000; Lee et al. 2003).These phenomena most likely reflect a complex mechanism, in which pre-existing anti-graft-reactive immunoglobulins are primarily adsorbed on complementary sites on the cell surfaces of the graft, however, other than on the surfaces of non-nucleated, metabolically weak red cells, they appear to be completed by graft-phenotype-specific, protective glycosylation that suggests the targeted use of this mechanism in a hypothetical therapeutic principle.
DOI: 10.6084/m9.figshare.3394639.v134
title: Spontaneous and therapeutic glycosidic accommodation of host and graft in ABO(H)-incompatible transplantation, a hypothesis.

description: In contrast to non-nucleated ABO(H) red cells, which when transfused to a blood group O(H) recipient undergo destruction within minutes, such hyperacute, humoral rejection occurs relatively rare in transplantations of highly nucleated, metabolically active solid organs, and it is extremely rare in liver transplantations (Adams 1991; Della-Guardia et al. 2008). Moreover, a case of transient, selective disappearance of preexisting donor-specific HLA-antibodies after an incompatible liver transplantation, without any rejection episodes, has been reported by Bastiani (2006), and according to Taner et al. (2014)<i> </i>such transient decrease of donor-specific HLA-antibodies is not uncommon after incompatible liver transplantation. In addition, an exponential fall in both anti-A/B reactive IgM and IgG titers were observed after ABO(H) incompatible bone marrow transplantation (Rowley et al. 2000; Lee et al. 2003). These phenomena most likely reflect a complex mechanism, in which pre-existing anti-graft-reactive immunoglobulins are adsorbed on complementary sites on the cell surfaces of the graft, however, other than on the surfaces of metabolically weak red cells, are transiently completed by graft-phenotype-specific, protective glycosylation, until depletion of the enzymatic power competing with the primarily superior host. <br>
DOI: 10.6084/m9.figshare.3394639.v135
title: Spontaneous and therapeutic glycosidic accommodation of host and graft in ABO(H)-incompatible transplantation, a hypothesis.

description: In contrast to non-nucleated ABO(H) red cells, which when transfused to a blood group O(H) recipient undergo destruction within minutes, such hyperacute, humoral rejection occurs relatively rare in transplantations of highly nucleated, metabolically active solid organs, and it is extremely rare in liver transplantations (Adams 1991; Della-Guardia et al. 2008). Moreover, a case of transient, selective disappearance of preexisting donor-specific HLA-antibodies after an incompatible liver transplantation, without any rejection episodes, has been reported by Bastiani (2006), and according to Taner et al. (2014)<i> </i>such transient decrease of donor-specific HLA-antibodies is not uncommon after incompatible liver transplantation. In addition, an exponential fall in both anti-A/B reactive IgM and IgG titers were observed after ABO(H) incompatible bone marrow transplantation (Rowley et al. 2000; Lee et al. 2003)These phenomena most likely reflect a complex mechanism, in which pre-existing anti-graft-reactive immunoglobulins are adsorbed on complementary sites on the cell surfaces of the graft, however, other than on the surfaces of metabolically weak red cells, are transiently completed by graft-phenotype-specific, protective glycosylation, until depletion of the graft-intrinsic enzymatic power competing with the primarily superior host. . <br>
DOI: 10.6084/m9.figshare.3394639.v136
title: Spontaneous and therapeutic glycosidic accommodation of host and graft in ABO(H)-incompatible transplantation, a hypothesis.

description: In contrast to non-nucleated ABO(H) red cells, which when transfused to a blood group O(H) recipient undergo destruction within minutes, such hyperacute, humoral rejection occurs relatively rare in transplantations of highly nucleated, metabolically active solid organs, and it is extremely rare in liver transplantations (Adams 1991; Della-Guardia et al. 2008). Moreover, a case of transient, selective disappearance of preexisting donor-specific HLA-antibodies after an incompatible liver transplantation, without any rejection episodes, has been reported by Bastiani (2006), and according to Taner et al. (2014)<i> </i>such transient decrease of donor-specific HLA-antibodies is not uncommon after incompatible liver transplantation. In addition, an exponential fall in both anti-A/B reactive IgM and IgG titers were observed after ABO(H) incompatible bone marrow transplantation (Rowley et al. 2000; Lee et al. 2003). These phenomena most likely reflect a complex mechanism, in which pre-existing anti-graft-reactive immunoglobulins are adsorbed on complementary sites on the cell surfaces of the graft, however are, unlike on the surfaces of metabolically weak red cells, temporarily completed by graft-phenotype-specific protective glycosylation, until depletion of the graft-intrinsic enzymatic power competing with the primarily superior host.<br>
DOI: 10.6084/m9.figshare.3394639.v137
title: Spontaneous and therapeutic glycosidic accommodation of host and graft in ABO(H)-incompatible transplantation, a hypothesis.

description: In contrast to non-nucleated ABO(H) red cells, which when transfused to a blood group O(H) recipient undergo destruction within minutes, such hyperacute, humoral rejection occurs relatively rare in transplantations of highly nucleated, metabolically active solid organs, and it is extremely rare in liver transplantations (Adams 1991; Della-Guardia et al. 2008). Moreover, a case of transient, selective disappearance of preexisting donor-specific HLA-antibodies after an incompatible liver transplantation, without any rejection episodes, has been reported by Bastiani (2006), and according to Taner et al. (2014)<i> </i>such transient decrease of donor-specific HLA-antibodies is not uncommon after incompatible liver transplantation. In addition, an exponential fall in both anti-A/B reactive IgM and IgG titers were observed after ABO(H) incompatible bone marrow transplantation (Rowley et al. 2000; Lee et al. 2003).These phenomena most likely reflect a complex mechanism, in which pre-existing anti-graft-reactive immunoglobulins are adsorbed on complementary sites on the cell surfaces of the graft, but other than on the surfaces of metabolically weak red cells, appear transiently to be completed by graft-phenotype-specific protective glycosylation and reappear when the graft-intrinsic enzymatic power is exhausted.
DOI: 10.6084/m9.figshare.3394639.v138
title: Spontaneous and therapeutic glycosidic accommodation of host and graft in ABO(H)-incompatible transplantation, a hypothesis.

description: In contrast to non-nucleated ABO(H) red cells, which when transfused to a blood group O(H) recipient undergo destruction within minutes, such hyperacute, humoral rejection occurs relatively rare in transplantations of highly nucleated, metabolically active solid organs, and it is extremely rare in liver transplantations (Adams 1991; Della-Guardia et al. 2008). Moreover, a case of transient, selective disappearance of preexisting donor-specific HLA-antibodies after an incompatible liver transplantation, without any rejection episodes, has been reported by Bastiani (2006), and according to Taner et al. (2014)<i> </i>such transient decrease of donor-specific HLA-antibodies is not uncommon after incompatible liver transplantation. In addition, an exponential fall in both anti-A/B reactive IgM and IgG titers were observed after ABO(H) incompatible bone marrow transplantation (Rowley et al. 2000; Lee et al. 2003).These phenomena most likely reflect a complex mechanism, in which pre-existing anti-graft-reactive immunoglobulins are adsorbed on complementary sites on the cell surfaces of the graft, but other than on the surfaces of metabolically weak red cells, appear transiently to be completed by graft-phenotype-specific protective glycosylation and reappear when the graft-intrinsic enzymatic power and supply of specific substrates are exhausted.