cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.8092241.v1
title: Effects of benzalkonium chloride and cyclosporine applied topically to rabbit conjunctiva: a histomorphometric study

description: ABSTRACT Purpose: Chronic instillation of benzalkonium chloride, a preservative, has inflammatory effects on the ocular surface. However, addition of the anti-inflammatory agent cyclosporine to a therapeutic protocol may mitigate these effects. This study compared the toxic effects of a 0.1% benzalkonium chloride solution and the possible protective effect of 0.05% cyclosporine when applied topically to the rabbit conjunctiva. Methods: Fifteen age- and weight-matched, female New Zealand white rabbits were categorized into three groups and treated for 30 consecutive days. Group 1, 2, and 3 - benzalkonium chloride received 0.1% every 24 h, 0.05% cyclosporine every 6 h, and both treatments, respectively. In each rabbit, the left eye was subjected to treatment and the right eye was a control. The rabbits were euthanized at after the experiment. Goblet cells and blood vessels were then enumerated in conjunctival tissues stained with periodic acid-Schiff and hematoxylin-eosin, respectively. Differences between treated and untreated eyes and between groups were compared using the t-test and analysis of variance. Results: Benzalkonium chloride treatment, with and without cyclosporine, significantly reduced (p≤0.05) in the number of goblet cells in treatment eyes compared with that in respective control eyes. Alternatively, adding cyclosporine to benzalkonium chloride did not prevent the loss of conjunctival goblet cells, and a significant reduction in the number of goblet cells was noted. Benzalkonium chloride-induced significant increase in the number of new blood vessels was mitigated significantly by the addition of cyclosporine. Conclusion: This study demonstrated the magnitude of conjunctival injury caused by chronic instillation of benzalkonium chloride. Although cyclosporine did not mitigate the effects on goblet cells, its addition minimized inflammatory angiogenesis induced by benzalkonium chloride.
DOI: 10.6084/m9.figshare.8092223
title: The effect of graft application and simvastatin treatment on tibial bone defect in rats. A histological and immunohistochemical study

description: Abstract Purpose: To evaluate histologically and immunohistochemically the bone regeneration after application of simvastatin on tibial bone defects in rats. Methods: Sixty Wistar albino rats were divided into 3 groups as control (6 mm tibial bone defect), defect + graft (allograft treatment), and defect + graft + simvastatin (10 mg/kg/day) for 28 days. Results: Histopathological examination revealed inflammation in control group (defect group), congestion in blood vessels, and an increase in osteoclast cells. In defect + graft group, osteoclastic activity was observed and osteocyte cells were continued to develop. In defect + graft + simvastatin group, osteocytes and matrix formation were increased in the new bone trabeculae. Osteopontin and osteonectin expression were positive in the osteclast cells in the control group. Osteoblasts and some osteocytes showed a positive reaction of osteopontin and osteopontin. In defect + graft + simvastatin group, osteonectin and osteopontin expression were positive in osteoblast and osteocyte cells, and a positive expression in osteon formation was also seen in new bone trabeculae. Conclusion: The simvastatin application was thought to increase bone turnover by increasing the osteoinductive effect with graft and significantly affect the formation of new bone.
DOI: 10.6084/m9.figshare.8092229
title: The effect of panretinal photocoagulation on confocal laser scanning ophthalmoscopy and stereo photographic parameters of optic disk topography in patients with diabetic retinopathy

description: ABSTRACT Purpose: To determine the effect of panretinal photocoagulation on optic disk topographic parameters in non-glaucomatous patients with proliferative diabetic retinopathy. Methods: This was a prospective, single-center, observational study. Thirty-eight eyes of 26 patients with diabetes underwent panretinal photocoagulation for proliferative diabetic retinopathy. Stereoscopic disk photographs and optic nerve head parameters were evaluated using the Zeiss fundus camera and the confocal scanning laser ophthalmoscope (Heidelberg Retinal Tomograph), respectively, at baseline and 12 months after the completion of panretinal photocoagulation. Results: Thirty-eight eyes of 26 patients (15 female) with a mean age of 53.7 (range 26-74) years were recruited. No significant difference was found between the stereo photography determined mean horizontal and vertical cup-to-disk ratio before and after panretinal photocoagulation treatment (p=0.461 and 0.839, respectively). The global values of the optic nerve head parameters analyzed with the HRT3 showed no significant change from baseline to 12 months, including the disk area, cup area, rim area, cup volume, rim volume, cup-to-disk area ratio, linear cup-to-disk ratio, mean cup depth, maximum cup depth, cup shape measure, height variation contour, mean retinal nerve fiber layer thickness, and cross-sectional area. Conclusion: Our results suggest that panretinal photocoagulation does not cause morphological optic disk changes in patients with diabetic proliferative retinopathy after 1 year of follow-up.
DOI: 10.6084/m9.figshare.8092232.v1
title: Relationship between erythrocyte sedimentation rate and choroidal and retinal thickness in Behçet's disease

description: ABSTRACT Purpose: To compare retinal and choroidal thickness in patients with Behçet's disease with and without ocular involvement as well as to evaluate the correlation between erythrocyte sedimentation rate and choroidal thickness among patients with Behçet's disease. Methods: This was a prospective interventional study investigating erythrocyte sedimentation as well as choroidal and retinal thickness among patients with Behçet's disease. Patients who were diagnosed based on The International Criteria for Behçet's Disease with (Group A) or without (Group B) ocular involvement and a matched control group (Group C) participated in the study. Optical coherence tomography measurements and blood tests were performed on the same day. Retinal and choroidal thickness were measured using spectral-domain optical coherence tomography (Spectralis, Heidelberg Engineering, Heidelberg, Germany), and central macular thickness, central subfoveal choroidal thickness, and retinal nerve fiber layer thickness were measured using optical coherence tomography. Results: Average erythrocyte sedimentation values were 9.89 mm/h in Group A, 16.21 mm/h in Group B, and 3.89 mm/h in Group C; average central subfoveal choroidal thickness values were 350.66, 331.74, and 325.95 mm, respectively. Average central macular thickness and retinal nerve fiber layer thickness values of patients in Groups A, B and C were 226.39 and 225.97mm; 234.11 and 92.00 mm; and 97.58 and 99.84 mm, respectively. No significant difference was seen between Group A and B patients in central subfoveal choroidal thickness, central macular thickness, or retinal nerve fiber layer thickness values. Central macular thickness was statistically significantly thinner in Groups A and B than in Group C (p=0.016). Group A had thinning in the nasal quadrant of the retinal and general retinal nerve fiber layers when compared with those in Group C (p=0.010 and 0.041, respectively). A connection could not be established between the erythrocyte sedimentation, central subfoveal choroidal thickness, central macular thickness, and retinal nerve fiber layer thickness in the patients with Behçet's disease. Conclusion: The erythrocyte sedimentation rate is typically used to test for activation of Behçet's disease and assess treatment response. In our study, we could not establish a connection between the erythrocyte sedimentation rate and central subfoveal choroidal thickness, central macular thickness, and retinal nerve fiber layer thickness in patients with systematically active Behçet's disease without ocular involvement.
DOI: 10.6084/m9.figshare.8092220
title: The interrelation between public debt and monetary policy in Brazil: a historical review

description: Abstract This paper aims to discuss the connection between monetary policy and public debt in Brazil, highlighting the consequences. To do so, it begins with a historical resumption of the emergence of the market for public debt and the institutions responsible for its management. This is followed by an analysis of the data on the variables related to monetary policy and public debt between 1999 and 2016. From this analysis, we observed the existence of a problematic connection between two policies - monetary and fiscal - given by the Selic rate, which is both an instrument to control the inflation and the rate that remunerates a significant portion of public debt. The paper concludes that this link reduces the effectiveness of these policies, requiring actions such as the untying of monetary policy and public debt, the increase in the term and duration of debt, the change in composition and, particularly, a reduction of the Selic rate.
DOI: 10.6084/m9.figshare.8092220.v1
title: The interrelation between public debt and monetary policy in Brazil: a historical review

description: Abstract This paper aims to discuss the connection between monetary policy and public debt in Brazil, highlighting the consequences. To do so, it begins with a historical resumption of the emergence of the market for public debt and the institutions responsible for its management. This is followed by an analysis of the data on the variables related to monetary policy and public debt between 1999 and 2016. From this analysis, we observed the existence of a problematic connection between two policies - monetary and fiscal - given by the Selic rate, which is both an instrument to control the inflation and the rate that remunerates a significant portion of public debt. The paper concludes that this link reduces the effectiveness of these policies, requiring actions such as the untying of monetary policy and public debt, the increase in the term and duration of debt, the change in composition and, particularly, a reduction of the Selic rate.
DOI: 10.6084/m9.figshare.8092223.v1
title: The effect of graft application and simvastatin treatment on tibial bone defect in rats. A histological and immunohistochemical study

description: Abstract Purpose: To evaluate histologically and immunohistochemically the bone regeneration after application of simvastatin on tibial bone defects in rats. Methods: Sixty Wistar albino rats were divided into 3 groups as control (6 mm tibial bone defect), defect + graft (allograft treatment), and defect + graft + simvastatin (10 mg/kg/day) for 28 days. Results: Histopathological examination revealed inflammation in control group (defect group), congestion in blood vessels, and an increase in osteoclast cells. In defect + graft group, osteoclastic activity was observed and osteocyte cells were continued to develop. In defect + graft + simvastatin group, osteocytes and matrix formation were increased in the new bone trabeculae. Osteopontin and osteonectin expression were positive in the osteclast cells in the control group. Osteoblasts and some osteocytes showed a positive reaction of osteopontin and osteopontin. In defect + graft + simvastatin group, osteonectin and osteopontin expression were positive in osteoblast and osteocyte cells, and a positive expression in osteon formation was also seen in new bone trabeculae. Conclusion: The simvastatin application was thought to increase bone turnover by increasing the osteoinductive effect with graft and significantly affect the formation of new bone.
DOI: 10.6084/m9.figshare.8092235.v1
title: Ultrasonographic characteristics of active ocular toxoplasmosis

description: ABSTRACT Purpose: To evaluate ophthalmic ultrasonographic findings associated with active ocular toxoplasmosis. Methods: Forty-seven eyes with active ocular toxoplasmosis in 47 patients were subjected to ocular ultrasonography using the transpalpebral technique (10-MHz transducer) and fundus photography. Patient medical records were retrospectively reviewed. Results: Ocular ultrasonography revealed vitritis, posterior vitreous detachment, retinal wall thickening, and non-rhegmatogenous retinal detachment in 47 (100%), 36 [76.6%; partial in 12 (25.5%) and total in 23 (48.9%)], 12 (25.5%), and 5 eyes (10.6%). Thirty-five of the 36 eyes with posterior vitreous detachment (97.2%) exhibited posterior hyaloid thickening; moreover, adhesion to the exudative lesion and vitreoschisis were observed in 4 (11.1%) and 12 eyes (25.5%), respectively. Ultrasonography detected the location of the exudative focus in 12 eyes (25.5%). Conclusion: Ultrasonography is helpful for detecting important intraocular findings of acute ocular toxoplasmosis that can be hindered by medial opacity or posterior synechiae.
DOI: 10.6084/m9.figshare.8092214
title: Polymorphism of the BCO2 gene and the content of carotenoids, retinol, and α-tocopherol in the liver and fat of rabbits

description: ABSTRACT The study was carried out to evaluate the effect of AAT-deletion mutation at codon 248 of the BCO2 gene on the content of lutein, β-carotene, retinol, and α-tocopherol in the liver and fat of crossbred rabbits. The experimental animals comprised 90 rabbits, produced by reciprocal crossing between ins/del heterozygous parents of Flemish Giant, New Zealand Red, and Termond White breeds. All rabbits in the litter were genotyped, given the same diet, and finally slaughtered at 140 d of age. It was found that regardless of the mating scheme employed, all del/del homozygotes had the yellow fat trait, whereas heterozygous and homozygotes animals without the AAT deletion (ins/ins) developed white fat. Lutein concentration in fat was over 13-fold higher in rabbits carrying a homozygous AAT-deletion than in the remaining animals. A codon deletion in the BCO2 gene also contributes to an increase in the concentrations of β-carotene and α-tocopherol in the adipose tissue of rabbits. However, no differences were observed in the content of the analyzed components between heterozygous and homozygous rabbits without the deletion.
DOI: 10.6084/m9.figshare.8092217
title: Forty years of the French regulation school: alternating between marxism and historical institutionalism

description: Abstract The French regulation school originated in the mid-1970s, with the aim of developing and updating Marx’s analysis of capitalism, in order to understand the economic transformations of the twentieth century. This marks the origin of the regime of accumulation, mode of regulation, institutional forms and Fordism concepts. Since the 1980s, the school has distanced itself from Marxism and has become more concerned with developing a historical and institutional approach. It was only after 2000 that the regulation approach identified the possibility of the existence of a finance-led regime of accumulation, argued by the school to have collapsed after the 2008 crisis. The problems that the French regulation school has in understanding capitalism from the 1980s onwards are associated with an inadequate theoretical view on the basic characteristics of the capitalist mode of production.
DOI: 10.6084/m9.figshare.8092229.v1
title: The effect of panretinal photocoagulation on confocal laser scanning ophthalmoscopy and stereo photographic parameters of optic disk topography in patients with diabetic retinopathy

description: ABSTRACT Purpose: To determine the effect of panretinal photocoagulation on optic disk topographic parameters in non-glaucomatous patients with proliferative diabetic retinopathy. Methods: This was a prospective, single-center, observational study. Thirty-eight eyes of 26 patients with diabetes underwent panretinal photocoagulation for proliferative diabetic retinopathy. Stereoscopic disk photographs and optic nerve head parameters were evaluated using the Zeiss fundus camera and the confocal scanning laser ophthalmoscope (Heidelberg Retinal Tomograph), respectively, at baseline and 12 months after the completion of panretinal photocoagulation. Results: Thirty-eight eyes of 26 patients (15 female) with a mean age of 53.7 (range 26-74) years were recruited. No significant difference was found between the stereo photography determined mean horizontal and vertical cup-to-disk ratio before and after panretinal photocoagulation treatment (p=0.461 and 0.839, respectively). The global values of the optic nerve head parameters analyzed with the HRT3 showed no significant change from baseline to 12 months, including the disk area, cup area, rim area, cup volume, rim volume, cup-to-disk area ratio, linear cup-to-disk ratio, mean cup depth, maximum cup depth, cup shape measure, height variation contour, mean retinal nerve fiber layer thickness, and cross-sectional area. Conclusion: Our results suggest that panretinal photocoagulation does not cause morphological optic disk changes in patients with diabetic proliferative retinopathy after 1 year of follow-up.
DOI: 10.6084/m9.figshare.8092208
title: Oxidative stress assessment in intestine of newborn rats submitted to hypoxia and reoxygenation with tadalafil

description: Abstract Purpose: To evaluate the functional and structural response of tadalafil effects in the intestinal mucosa, using an experimental model of hypoxia and reoxygenation injury in rats. Methods: The animals were divided into 4 groups: CTL, H/R, H/R+Td and M+Td. The newborn rats allocated in groups H/R, H/R+Td and M+Td were submitted twice a day, to a gas chamber with CO2 at 100% for 10 minutes and afterward reoxygenation with O2 at 98% for 10 minutes, in the three first days of life. Tadalafil dose was given to newborn of group H/R+Td and to the pregnant rat of group M+Td. Histological analysis was made with hematoxylin-eosin technique and oxidative stress through nitrite and nitrate levels and lipid peroxidation. Results: The histological analysis showed a reduction of mucosa alterations in the groups that received tadalafil. In the oxidative stress evaluation, occurred an increase of NO levels and less lipidic peroxidation in the ileum segments that received tadalafil. Conclusion: Tadalafil provides tissue protection when administered independently to both, pregnant or newborns.
DOI: 10.6084/m9.figshare.8092211
title: The competitiveness matrix and the role of emerging markets in Argentine and Brazilian exports

description: Abstract The general objective of this study is to analyze the evolution of Argentina and Brazil’s export structures between 1985 and 2010, through the competitiveness matrix developed by Fajnzylber and Mandeng. The specific objective is to identify links between the form that the competitiveness matrix takes over time and the evolution of the markets analyzed (OECD, Mercosur, Asia Developing and WORLD). The results confirm that the markets of emerging countries favor the most dynamic and competitive exports from Argentina and Brazil. However, while the Argentine and Brazilian exports to Mercosur are composed of more sophisticated manufactures, exports to developing countries in Asia are almost entirely natural resources and commodities.
DOI: 10.6084/m9.figshare.8092214.v1
title: Polymorphism of the BCO2 gene and the content of carotenoids, retinol, and α-tocopherol in the liver and fat of rabbits

description: ABSTRACT The study was carried out to evaluate the effect of AAT-deletion mutation at codon 248 of the BCO2 gene on the content of lutein, β-carotene, retinol, and α-tocopherol in the liver and fat of crossbred rabbits. The experimental animals comprised 90 rabbits, produced by reciprocal crossing between ins/del heterozygous parents of Flemish Giant, New Zealand Red, and Termond White breeds. All rabbits in the litter were genotyped, given the same diet, and finally slaughtered at 140 d of age. It was found that regardless of the mating scheme employed, all del/del homozygotes had the yellow fat trait, whereas heterozygous and homozygotes animals without the AAT deletion (ins/ins) developed white fat. Lutein concentration in fat was over 13-fold higher in rabbits carrying a homozygous AAT-deletion than in the remaining animals. A codon deletion in the BCO2 gene also contributes to an increase in the concentrations of β-carotene and α-tocopherol in the adipose tissue of rabbits. However, no differences were observed in the content of the analyzed components between heterozygous and homozygous rabbits without the deletion.
DOI: 10.6084/m9.figshare.8092205
title: Mapping the action patterns of countries in Global Value Chains and the gains in terms of structural change

description: Abstract This article aims to map the patterns of actions carried out by countries in Global Value Chains (GVC) and their gains, in order to identify under which circumstances such actions were accompanied by structural change. These patterns refer to the insertion of countries in GVC and possible evolutions through different types of upgrading. The mapping was carried out using a sample of 40 countries between 1995 and 2008, with 12 indicators that captured characteristics of the participation in this process. Due to the amount of information, we used cluster analysis, which combined with other analytical criteria, identified six patterns of insertion and upgrading of countries in global chains related to structural change potential. It was found that the intensity of structural change is associated with specific action patterns in the chains related to functional and chain upgrading, and by the latter, the structural change occurring only in countries located at the initial productive stage.
DOI: 10.6084/m9.figshare.8092208.v1
title: Oxidative stress assessment in intestine of newborn rats submitted to hypoxia and reoxygenation with tadalafil

description: Abstract Purpose: To evaluate the functional and structural response of tadalafil effects in the intestinal mucosa, using an experimental model of hypoxia and reoxygenation injury in rats. Methods: The animals were divided into 4 groups: CTL, H/R, H/R+Td and M+Td. The newborn rats allocated in groups H/R, H/R+Td and M+Td were submitted twice a day, to a gas chamber with CO2 at 100% for 10 minutes and afterward reoxygenation with O2 at 98% for 10 minutes, in the three first days of life. Tadalafil dose was given to newborn of group H/R+Td and to the pregnant rat of group M+Td. Histological analysis was made with hematoxylin-eosin technique and oxidative stress through nitrite and nitrate levels and lipid peroxidation. Results: The histological analysis showed a reduction of mucosa alterations in the groups that received tadalafil. In the oxidative stress evaluation, occurred an increase of NO levels and less lipidic peroxidation in the ileum segments that received tadalafil. Conclusion: Tadalafil provides tissue protection when administered independently to both, pregnant or newborns.
DOI: 10.6084/m9.figshare.8092217.v1
title: Forty years of the French regulation school: alternating between marxism and historical institutionalism

description: Abstract The French regulation school originated in the mid-1970s, with the aim of developing and updating Marx’s analysis of capitalism, in order to understand the economic transformations of the twentieth century. This marks the origin of the regime of accumulation, mode of regulation, institutional forms and Fordism concepts. Since the 1980s, the school has distanced itself from Marxism and has become more concerned with developing a historical and institutional approach. It was only after 2000 that the regulation approach identified the possibility of the existence of a finance-led regime of accumulation, argued by the school to have collapsed after the 2008 crisis. The problems that the French regulation school has in understanding capitalism from the 1980s onwards are associated with an inadequate theoretical view on the basic characteristics of the capitalist mode of production.