cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.23259219
title: Ocular side effects of systemic isotretinoin – a systematic review and summary of case reports

description: <b>Background:</b> Isotretinoin is frequently used for treatment of severe nodulocystic and papulopustular acne, however use is limited by mucocutaneous, ocular, and systemic side effects. <b>Objective:</b> (1) provide a systematic meta-analysis of ocular side effects during isotretinoin use and their corresponding incidences; (2) provide a narrative summary of ocular side effects during isotretinoin use reported in case reports. <b>Methods:</b> A systematic database search using predefined search terms was performed in PubMed, EMBASE, and Scopus from inception to 5 March, 2021. Predetermined inclusion and exclusion criteria were used to select included studies. In total, 53 original studies qualified for meta-analysis, and 41 case reports/series qualified for narrative results. <b>Results:</b> The studies included in the meta-analysis reported incidences of various ocular side effects including dry eye, eye sensitivity, vision changes, and ocular inflammatory conditions. Incidences across studies did vary, leading to considerable heterogeneity. The narrative results summarize more uncommon, but equally important, ocular side effects. <b>Conclusions:</b> Dry eye is the most commonly reported ocular side effect. Other less common, but more serious, ocular side effects including vision changes can occur. We recommend that isotretinoin prescribers monitor for dry eye. Limitations include the heterogeneity of reported incidences of ocular side effects between studies.
DOI: 10.6084/m9.figshare.23259219.v1
title: Ocular side effects of systemic isotretinoin – a systematic review and summary of case reports

description: <b>Background:</b> Isotretinoin is frequently used for treatment of severe nodulocystic and papulopustular acne, however use is limited by mucocutaneous, ocular, and systemic side effects. <b>Objective:</b> (1) provide a systematic meta-analysis of ocular side effects during isotretinoin use and their corresponding incidences; (2) provide a narrative summary of ocular side effects during isotretinoin use reported in case reports. <b>Methods:</b> A systematic database search using predefined search terms was performed in PubMed, EMBASE, and Scopus from inception to 5 March, 2021. Predetermined inclusion and exclusion criteria were used to select included studies. In total, 53 original studies qualified for meta-analysis, and 41 case reports/series qualified for narrative results. <b>Results:</b> The studies included in the meta-analysis reported incidences of various ocular side effects including dry eye, eye sensitivity, vision changes, and ocular inflammatory conditions. Incidences across studies did vary, leading to considerable heterogeneity. The narrative results summarize more uncommon, but equally important, ocular side effects. <b>Conclusions:</b> Dry eye is the most commonly reported ocular side effect. Other less common, but more serious, ocular side effects including vision changes can occur. We recommend that isotretinoin prescribers monitor for dry eye. Limitations include the heterogeneity of reported incidences of ocular side effects between studies.
DOI: 10.6084/m9.figshare.22955101
title: The differential effects of upadacitinib treatment on skin rashes of four anatomical sites in patients with atopic dermatitis

description: Upadacitinib is an oral Janus kinase (JAK) 1 inhibitor approved in Japan for moderate-to-severe atopic dermatitis (AD), and it provides a high therapeutic efficacy. We compared the therapeutic effects of upadacitinib on skin rashes of individual anatomical sites, head and neck, upper limbs, lower limbs, and trunk in patients with AD. From August 2021 to December 2022, 65 Japanese patients with moderate-to-severe AD (aged ≥ 12 years) were treated with oral once daily upadacitinib 15 mg plus twice daily topical corticosteroids of moderate-to-strongest classes. The eczema area and severity indexes (EASIs) of individual sites decreased significantly at weeks 4, 12, and 24 compared to those at week 0 in parallel to total (whole body) EASI. The achievement rates of EASI 75 at week 24 and of EASI 90 at week 12 of lower limbs were significantly higher than those of trunk. The percent reductions of EASI of lower limbs at weeks 12 and 24 were significantly higher than those of head and neck and of trunk. Among the four anatomical sites, the treatment responsiveness to upadacitinib in lower limbs appeared the highest, while those in trunk and in head and neck appeared relatively lower.
DOI: 10.6084/m9.figshare.22955101.v1
title: The differential effects of upadacitinib treatment on skin rashes of four anatomical sites in patients with atopic dermatitis

description: Upadacitinib is an oral Janus kinase (JAK) 1 inhibitor approved in Japan for moderate-to-severe atopic dermatitis (AD), and it provides a high therapeutic efficacy. We compared the therapeutic effects of upadacitinib on skin rashes of individual anatomical sites, head and neck, upper limbs, lower limbs, and trunk in patients with AD. From August 2021 to December 2022, 65 Japanese patients with moderate-to-severe AD (aged ≥ 12 years) were treated with oral once daily upadacitinib 15 mg plus twice daily topical corticosteroids of moderate-to-strongest classes. The eczema area and severity indexes (EASIs) of individual sites decreased significantly at weeks 4, 12, and 24 compared to those at week 0 in parallel to total (whole body) EASI. The achievement rates of EASI 75 at week 24 and of EASI 90 at week 12 of lower limbs were significantly higher than those of trunk. The percent reductions of EASI of lower limbs at weeks 12 and 24 were significantly higher than those of head and neck and of trunk. Among the four anatomical sites, the treatment responsiveness to upadacitinib in lower limbs appeared the highest, while those in trunk and in head and neck appeared relatively lower.
DOI: 10.6084/m9.figshare.21806102
title: Intralesional corticosteroid administration in the treatment of keloids: a survey among Dutch dermatologists and plastic surgeons

description: Intralesional corticosteroid administration (ICA) is a first-line therapy in keloid treatment. However, its clinical results are still highly variable and often suboptimal. Treatment results may strongly be influenced by various ways of ICA. To explore the prevailing practice of ICA in keloid treatment among dermatologists and plastic surgeons in the Netherlands. The survey was constructed based on a scoping review on ICA in keloid treatment. Members of the Dutch Society for Plastic surgery and the Dutch Society for Dermatology and Venereology were asked to participate. One hundred and thirty-six responses were obtained. One hundred and thirty (95.6%) participants used triamcinolone acetonide. The majority (54.7%) did not use local anesthesia for pain reduction. Reported corticosteroid dosing that one would inject in one specific keloid differed by a factor of 40. Treatment intervals varied from 1 week to more than 8 weeks. The keloid center was most often injected (46.9%), followed by subepidermal (18.0%). A wide variety in ICA for keloids is noted among dermatologists and plastic surgeons, even in a limited geographic region and when evidence points toward an optimal way of treatment. Future studies and better implementation of existing evidence may reduce variation in ICA and optimize its treatment results.
DOI: 10.6084/m9.figshare.21806102.v2
title: Intralesional corticosteroid administration in the treatment of keloids: a survey among Dutch dermatologists and plastic surgeons

description: Intralesional corticosteroid administration (ICA) is a first-line therapy in keloid treatment. However, its clinical results are still highly variable and often suboptimal. Treatment results may strongly be influenced by various ways of ICA. To explore the prevailing practice of ICA in keloid treatment among dermatologists and plastic surgeons in the Netherlands. The survey was constructed based on a scoping review on ICA in keloid treatment. Members of the Dutch Society for Plastic surgery and the Dutch Society for Dermatology and Venereology were asked to participate. One hundred and thirty-six responses were obtained. One hundred and thirty (95.6%) participants used triamcinolone acetonide. The majority (54.7%) did not use local anesthesia for pain reduction. Reported corticosteroid dosing that one would inject in one specific keloid differed by a factor of 40. Treatment intervals varied from 1 week to more than 8 weeks. The keloid center was most often injected (46.9%), followed by subepidermal (18.0%). A wide variety in ICA for keloids is noted among dermatologists and plastic surgeons, even in a limited geographic region and when evidence points toward an optimal way of treatment. Future studies and better implementation of existing evidence may reduce variation in ICA and optimize its treatment results.
DOI: 10.6084/m9.figshare.24466158.v1
title: Gabapentin and oral antidepressants for chronic pruritus: a prospective cohort study evaluating efficacy and side effects in daily dermatological practice

description: Chronic pruritus is frequently seen in daily dermatological practice and is associated with marked impact on quality of life. Research on the use of gabapentin and oral antidepressants in daily dermatological practice is scarce. To evaluate the efficacy and safety of gabapentin and oral antidepressants in patients with chronic pruritus in daily clinical practice. A prospective observational single-center cohort study was conducted including adult patients with chronic pruritus and an indication for systemic treatment between June 2016 and May 2019. Systemic treatment with gabapentin and/or antidepressants was initiated in 31 patients with severe chronic pruritus (median average pruritus NRS score 7.0), in which most cases no underlying origin was identified (83.9%). In patients treated with gabapentin 900–1800 mg/day (<i>N</i> = 25), median average pruritus NRS decreased to 5.5 (IQR 3.0) after 4 weeks and remained stable up to 24 weeks of treatment. Efficacy of antidepressants was variable, with the highest response after initiation of amitriptyline, nortriptyline, and mirtazapine. Side effects were frequently observed in both gabapentin and antidepressant treatments; however, were mostly mild and temporary. This was a single-site observational study, with limited sample size. Treatment with gabapentin and antidepressants should be considered in patients with chronic pruritus unresponsive to conventional treatment.
DOI: 10.6084/m9.figshare.24466158
title: Gabapentin and oral antidepressants for chronic pruritus: a prospective cohort study evaluating efficacy and side effects in daily dermatological practice

description: Chronic pruritus is frequently seen in daily dermatological practice and is associated with marked impact on quality of life. Research on the use of gabapentin and oral antidepressants in daily dermatological practice is scarce. To evaluate the efficacy and safety of gabapentin and oral antidepressants in patients with chronic pruritus in daily clinical practice. A prospective observational single-center cohort study was conducted including adult patients with chronic pruritus and an indication for systemic treatment between June 2016 and May 2019. Systemic treatment with gabapentin and/or antidepressants was initiated in 31 patients with severe chronic pruritus (median average pruritus NRS score 7.0), in which most cases no underlying origin was identified (83.9%). In patients treated with gabapentin 900–1800 mg/day (<i>N</i> = 25), median average pruritus NRS decreased to 5.5 (IQR 3.0) after 4 weeks and remained stable up to 24 weeks of treatment. Efficacy of antidepressants was variable, with the highest response after initiation of amitriptyline, nortriptyline, and mirtazapine. Side effects were frequently observed in both gabapentin and antidepressant treatments; however, were mostly mild and temporary. This was a single-site observational study, with limited sample size. Treatment with gabapentin and antidepressants should be considered in patients with chronic pruritus unresponsive to conventional treatment.
DOI: 10.6084/m9.figshare.23523622
title: Engineering extracellular vesicles with macrophage membrane fusion for ameliorating imiquimod-induced psoriatic skin inflammation

description: Herein, we developed an engineered extracellular vehicle (EV)-based method for ameliorating inflammatory responses in psoriasis. EVs, derived from annexin A1 (ANXA1) overexpressing T cells, were co-extruded with M2 macrophage membrane to obtain engineered EVs. <i>In vitro</i>, the effect of engineered EVs on macrophage polarization was evaluated by real-time PCR. In imiquimod (IMQ)-induced psoriasis-like mouse model, the efficacy of engineered EVs in ameliorating psoriatic inflammation was evaluated by Psoriasis Area and Severity Index (PASI) score and immunohistochemistry staining after subcutaneous injection of EVs. The engineered EVs not only preserved the high stability of M2 macrophage membrane but also retained the macrophage reprogramming potential of ANXA1 overexpressed in T cells. In the psoriasis-like mouse model, subcutaneous injection of engineered EVs successfully reduced the PASI score and the levels of pro-inflammatory cytokines, including IL-1β, IL-6, and TNF-α. Along with high biosafety, the administration of EVs also rescued the histomorphological changes of spleen, liver, and kidney. The engineered EVs exhibited the potential to alleviate inflammation of psoriasis, providing new insights and potential strategies for the immunotherapies of psoriasis.
DOI: 10.6084/m9.figshare.23523622.v1
title: Engineering extracellular vesicles with macrophage membrane fusion for ameliorating imiquimod-induced psoriatic skin inflammation

description: Herein, we developed an engineered extracellular vehicle (EV)-based method for ameliorating inflammatory responses in psoriasis. EVs, derived from annexin A1 (ANXA1) overexpressing T cells, were co-extruded with M2 macrophage membrane to obtain engineered EVs. <i>In vitro</i>, the effect of engineered EVs on macrophage polarization was evaluated by real-time PCR. In imiquimod (IMQ)-induced psoriasis-like mouse model, the efficacy of engineered EVs in ameliorating psoriatic inflammation was evaluated by Psoriasis Area and Severity Index (PASI) score and immunohistochemistry staining after subcutaneous injection of EVs. The engineered EVs not only preserved the high stability of M2 macrophage membrane but also retained the macrophage reprogramming potential of ANXA1 overexpressed in T cells. In the psoriasis-like mouse model, subcutaneous injection of engineered EVs successfully reduced the PASI score and the levels of pro-inflammatory cytokines, including IL-1β, IL-6, and TNF-α. Along with high biosafety, the administration of EVs also rescued the histomorphological changes of spleen, liver, and kidney. The engineered EVs exhibited the potential to alleviate inflammation of psoriasis, providing new insights and potential strategies for the immunotherapies of psoriasis.
DOI: 10.14473/csda/xh0j15/kpspnw
title: Nesstar_NS_DataFile_0706.tab

description: Data
DOI: 10.14473/csda/xh0j15/sssuia
title: K_V0706.pdf

description: Karty
DOI: 10.14473/csda/xh0j15/pzrhtb
title: OM_V0706.pdf

description: Ostatní materiály
DOI: 10.14473/csda/xh0j15/mblv65
title: TI_V0706.pdf

description: Technická informace
DOI: 10.14473/csda/xh0j15/qes9io
title: PR02_V0706.pdf

description: Čeští občané o nezaměstnanosti. Tisková zpráva CVVM.
DOI: 10.14473/csda/xh0j15/yodrji
title: D_V0706.pdf

description: Dotazník
DOI: 10.14473/csda/xh0j15/aopdu5
title: PR06_V0706.pdf

description: Důvěra k ústavním institucím a spokojenost s politickou situací v červnu 2007. Tisková zpráva CVVM.
DOI: 10.14473/csda/xh0j15/nzp2wd
title: PR01_V0706.pdf

description: Prestiž povolání. Tisková zpráva CVVM.
DOI: 10.14473/csda/xh0j15/dw6hsm
title: PR08_V0706.pdf

description: Spokojenost se stavem některých oblastí. Tisková zpráva CVVM.
DOI: 10.14473/csda/xh0j15/janrpm
title: PR07_V0706.pdf

description: Veřejné mínění o americké radarové základně v ČR. Tisková zpráva CVVM.
DOI: 10.14473/csda/xh0j15/vxyfbf
title: PR03_V0706.pdf

description: Češi o některých aspektech pracovního života. Tisková zpráva CVVM.
DOI: 10.14473/csda/xh0j15/vdqwdh
title: PR04_V0706.pdf

description: Hodnocení ekonomické transformace po roce 1989. Tisková zpráva CVVM.
DOI: 10.14473/csda/xh0j15/tsohbw
title: PR05_V0706.pdf

description: Ekonomická situace a materiální životní podmínky z pohledu veřejného mínění ve středoevropském srovnání. Tisková zpráva CVVM.
DOI: 10.14473/csda/xh0j15
title: Naše společnost 2007 - červen

description: Kontinuální měsíční výzkum provedl výzkumný tým CVVM Sociologického ústavu AV ČR v rámci pravidelného měsíčního výzkumného projektu. Jsou při něm zjišťovány postoje a názory občanů. Výzkum provedl výzkumný tým CVVM Sociologického ústavu AV ČR v rámci výzkumu. "Naše společnost 2007". Sběr dat provedla tazatelská síť CVVM.
DOI: 10.14473/csda/xh0j15/w2egps
title: PR09_V0706.pdf

description: Stranické preference a volební model v červnu 2007. Tisková zpráva CVVM.
DOI: 10.6084/m9.figshare.25451449.v1
title: Supplementary Material for: Association between sense of coherence and caries activity and caries experience among male adolescents from southern Brazil: a cross-sectional study

description: Introduction: This cross-sectional study assessed the association between sense of coherence (SoC) and caries activity (number of active caries lesions) and caries experience (DMFT index) among 18-19-year-old male adolescents who joined the Brazilian Army as draftees for mandatory military service (n=507). Methods: Data collection included a questionnaire (level of education, family income, and tooth brushing frequency), the Brazilian short version of the SoC scale (SOC-13), and clinical caries examination (non-cavitated/cavitated, inactive/active). The main predictor variable was SoC, categorized as low, moderate, or high. Poisson regression models were used for statistical analysis. Results: A high SoC was significantly associated with a lower number of active lesions (adjusted rate ratio = 0.85; 95% confidence interval = 0.74-0.98). No association between SoC and DMFT was detected. Conclusion: A high SoC was found to be a protective factor to caries activity in this population.
DOI: 10.5281/zenodo.7829131
title: Experimental Data for Dynamic Flow Reactions of 1,2,4-Triazole with Acrylonitrile

description: The reaction input flow rates, temperatures and concentrations are provided for time intervals of roughly 12 s. At each of these points, the concentration of four species was measured by online benchtop NMR analysis and these concentrations are provided. Experiments 1-7 and the self-optimization data are detailed in the manuscript (part 1).
DOI: 10.5281/zenodo.10849200
title: Experimental Data for Dynamic Flow Reactions of 1,2,4-Triazole with Acrylonitrile

description: The reaction input flow rates, temperatures and concentrations are provided for time intervals of roughly 12 s. At each of these points, the concentration of four species was measured by online benchtop NMR analysis and these concentrations are provided.


Experiments 1-7 and the self-optimization data are detailed in the manuscript (part 1).
description: 25.06.2023: File "Dynamic data_Experiment 1.xlsx" has been updated, due to incorrect data in one column.

21.03.2024: File "Dynamic data_Experiment 6.xlsx" has been re-uploaded, since this was a duplicate of the "Experiment 7" file.
DOI: 10.5281/zenodo.7829130
title: Experimental Data for Dynamic Flow Reactions of 1,2,4-Triazole with Acrylonitrile

description: The reaction input flow rates, temperatures and concentrations are provided for time intervals of roughly 12 s. At each of these points, the concentration of four species was measured by online benchtop NMR analysis and these concentrations are provided.


Experiments 1-7 and the self-optimization data are detailed in the manuscript (part 1).
description: 25.06.2023: File "Dynamic data_Experiment 1.xlsx" has been updated, due to incorrect data in one column.

21.03.2024: File "Dynamic data_Experiment 6.xlsx" has been re-uploaded, since this was a duplicate of the "Experiment 7" file.
DOI: 10.5281/zenodo.8079894
title: Experimental Data for Dynamic Flow Reactions of 1,2,4-Triazole with Acrylonitrile

description: The reaction input flow rates, temperatures and concentrations are provided for time intervals of roughly 12 s. At each of these points, the concentration of four species was measured by online benchtop NMR analysis and these concentrations are provided. Experiments 1-7 and the self-optimization data are detailed in the manuscript (part 1).
DOI: 10.5281/zenodo.8079910
title: Experimental Data for Dynamic Flow Reactions of 1,2,4-Triazole with Acrylonitrile

description: The reaction input flow rates, temperatures and concentrations are provided for time intervals of roughly 12 s. At each of these points, the concentration of four species was measured by online benchtop NMR analysis and these concentrations are provided. Experiments 1-7 and the self-optimization data are detailed in the manuscript (part 1).
description: 25.06.2023: File "Dynamic data_Experiment 1.xlsx" has been updated, due to incorrect data in one column.
DOI: 10.6084/m9.figshare.25449355
title: <b>Integrated Analysis of Tumor-Associated Macrophages and M2 Macrophages in CRC: Unraveling Molecular Heterogeneity and Developing a Novel Risk Signature</b>

description: Background: Emerging investigations have increasingly highlighted the critical role of tumor-associated macrophages (TAMs) and M2 macrophages in cancer development, progression, and metastasis, marking them as potential targets in various cancer types. The main objective of this research is to discover new biomarkers associated with TAM-M2 macrophages in colorectal cancer (CRC) and to dissect the molecular heterogeneity of CRC by combining single-cell RNA sequencing and bulk RNA-seq data.Methods: By utilizing weighted gene co-expression network analysis (WGCNA), we acquired TAM-M2-associated genes by intersecting TAM marker genes obtained from scRNA-seq data with module genes of M2 macrophages derived from bulk RNA-seq data. We employed least absolute shrinkage and selection operator (LASSO) Cox analysis to select predictive biomarkers from these TAM-M2-related genes. Quantitative polymerase chain reaction (qPCR) was employed to validate the mRNA expression levels of the genes identified in the screening. This led to the development of the TAM-M2-related signature (TAMM2RS). We also conducted functional and immune landscape analyses of different risk groups.Results: The combination of scRNA-seq and bulk RNA-seq analyses yielded 377 TAM-M2-related genes. DAPK1, NAGK, and TRAF1 emerged as key prognostic genes in CRC, which were identified through LASSO Cox analysis. Utilizing these genes, we constructed and validated the TAMM2RS, demonstrating its effectiveness in predicting survival in CRC patients.Conclusion: Our research offers a thorough investigation into the molecular mechanisms associated with TAM-M2 macrophages in CRC and unveils potential therapeutic targets, offering new insights for treatment strategies in colorectal cancer.<br>