cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.21904882.v1
title: Risk factors for the recurrence of pelvic organ prolapse: a meta-analysis

description: Female pelvic organ prolapse (POP) is a common condition, which has a high recurrence rate after reconstructive surgery, and the risk factors for POP recurrence are unclear. The aim of this study was to perform a meta-analysis to determine risk factors for POP recurrence. A thorough search of PubMed, Medline, EMBASE, Cochrane Central Register of Controlled Trials, and China Academic Journal Network Publishing Database was conducted for relevant publications until 29 October 2022, without language restrictions. A total of 29 studies involving 6597 patients were included, and the recurrence rate of POP after surgery was 37.7%. Significant OR and CI were found for levator avulsion (OR: 2.46, 95% CI: 1.80–3.36), preoperative stage ≥ III (OR: 1.87, 95% CI: 1.53–2.27), hiatal area on Valsalva manoeuvre (OR: 1.08, 95% CI: 1.03–1.12) and previous pelvic floor surgery (OR: 1.60, 95% CI: 1.07–2.39). Levator avulsion, preoperative stage ≥ III, hiatal area on Valsalva manoeuvre and previous pelvic floor surgery are significant risk factors for POP recurrence.IMPACT STATEMENT<b>What is already known on this subject?</b> It has been reported that genetic factors, parity, obesity, birth-induced injury during delivery, etc. are risk factors for POP development and recurrence after operation.<b>What do the results of this study add?</b> There are few literatures about the risk factors of POP recurrence at present. Our research has increased the information regarding risk factors for POP recurrence.<b>What are the implications of these findings for clinical practice and/or further research?</b> Our study provides an overview of the risk factors affecting POP recurrence and their contribution (OR, CI) to POP recurrence, which provides valuable evidence-based basis for clinical decision-making in POP treatment and prevention of POP recurrence. <b>What is already known on this subject?</b> It has been reported that genetic factors, parity, obesity, birth-induced injury during delivery, etc. are risk factors for POP development and recurrence after operation. <b>What do the results of this study add?</b> There are few literatures about the risk factors of POP recurrence at present. Our research has increased the information regarding risk factors for POP recurrence. <b>What are the implications of these findings for clinical practice and/or further research?</b> Our study provides an overview of the risk factors affecting POP recurrence and their contribution (OR, CI) to POP recurrence, which provides valuable evidence-based basis for clinical decision-making in POP treatment and prevention of POP recurrence.
DOI: 10.6084/m9.figshare.22297095
title: Clinical significance of the CD98hc-CD147 complex in ovarian cancer: a bioinformatics analysis

description: Ovarian cancer is one of the most common malignant tumours affecting the female reproductive organs. CD147 (BSG) and CD98hc (SLC3A2) are oncogenes that form the CD98hc-CD147 complex, which regulates the proliferation, metastasis, metabolism, and cell cycle of cancer cells. The roles of the CD98hc-CD147 complex in ovarian cancer remain unclear. We analysed the expression and prognostic value of CD147 and CD98hc in ovarian cancer using the TCGA and ICGC databases. The effect of CD147 and CD98hc on the tumour immune response was analysed using the TIMER database. CD98hc was more highly expressed in normal tissues than primary tumour tissues, while CD147 was more highly expressed in primary tumour tissues than normal tissues. CD98hc expression was significantly associated with neutrophil and dendritic cell levels. CD147 and CD98hc were correlated with DNA repair, the cell cycle, and DNA replication. The CD98hc-CD147 complex could serve as a target for ovarian cancer treatment. <b>What is already known on this subject?</b> CD98hc and CD147 are oncogenes that induce the proliferation and metastasis of cancer cells. The CD98hc-CD147 complex has been identified as a risk factor for cancer patients and causes resistance to cancer treatment.<b>What do the results of this study add?</b> We confirmed the expression levels of CD98hc and CD147 in ovarian cancer tissues and the effects of these oncogenes on the tumour immune response.<b>What are the implications of these findings for clinical practice and/or further research?</b> The CD98hc-CD147 complex may serve as a new target for ovarian cancer therapy. <b>What is already known on this subject?</b> CD98hc and CD147 are oncogenes that induce the proliferation and metastasis of cancer cells. The CD98hc-CD147 complex has been identified as a risk factor for cancer patients and causes resistance to cancer treatment. <b>What do the results of this study add?</b> We confirmed the expression levels of CD98hc and CD147 in ovarian cancer tissues and the effects of these oncogenes on the tumour immune response. <b>What are the implications of these findings for clinical practice and/or further research?</b> The CD98hc-CD147 complex may serve as a new target for ovarian cancer therapy.
DOI: 10.6084/m9.figshare.22297095.v1
title: Clinical significance of the CD98hc-CD147 complex in ovarian cancer: a bioinformatics analysis

description: Ovarian cancer is one of the most common malignant tumours affecting the female reproductive organs. CD147 (BSG) and CD98hc (SLC3A2) are oncogenes that form the CD98hc-CD147 complex, which regulates the proliferation, metastasis, metabolism, and cell cycle of cancer cells. The roles of the CD98hc-CD147 complex in ovarian cancer remain unclear. We analysed the expression and prognostic value of CD147 and CD98hc in ovarian cancer using the TCGA and ICGC databases. The effect of CD147 and CD98hc on the tumour immune response was analysed using the TIMER database. CD98hc was more highly expressed in normal tissues than primary tumour tissues, while CD147 was more highly expressed in primary tumour tissues than normal tissues. CD98hc expression was significantly associated with neutrophil and dendritic cell levels. CD147 and CD98hc were correlated with DNA repair, the cell cycle, and DNA replication. The CD98hc-CD147 complex could serve as a target for ovarian cancer treatment. <b>What is already known on this subject?</b> CD98hc and CD147 are oncogenes that induce the proliferation and metastasis of cancer cells. The CD98hc-CD147 complex has been identified as a risk factor for cancer patients and causes resistance to cancer treatment.<b>What do the results of this study add?</b> We confirmed the expression levels of CD98hc and CD147 in ovarian cancer tissues and the effects of these oncogenes on the tumour immune response.<b>What are the implications of these findings for clinical practice and/or further research?</b> The CD98hc-CD147 complex may serve as a new target for ovarian cancer therapy. <b>What is already known on this subject?</b> CD98hc and CD147 are oncogenes that induce the proliferation and metastasis of cancer cells. The CD98hc-CD147 complex has been identified as a risk factor for cancer patients and causes resistance to cancer treatment. <b>What do the results of this study add?</b> We confirmed the expression levels of CD98hc and CD147 in ovarian cancer tissues and the effects of these oncogenes on the tumour immune response. <b>What are the implications of these findings for clinical practice and/or further research?</b> The CD98hc-CD147 complex may serve as a new target for ovarian cancer therapy.
DOI: 10.6084/m9.figshare.21941503
title: Identification of potential prognostic biomarkers in vulval squamous cell carcinoma based on human papillomavirus infection Status-Analysis of GSE183454

description: This study aimed to elucidate the differences in vulval squamous cell carcinomas (VSCC) based on the HPV infection status. The sequencing data GSE183454 which contains 23 VSCC samples based on its HPV infection status was obtained from the Gene Expression Omnibus (GEO) database. We comprehensively dissected the differences of genomic and tumour microenvironment (TME) immune cell infiltration landscapes between HPV + and HPV- VSCC. The potential molecular mechanisms of prognostic genes were explored by functional enrichment analysis. Five novel key molecules (SYCP2, SMC1B, RNF212, MAJIN and C14orf39) with significantly up-regulated expression in HPV + VSCC were identified while protein-protein interaction (PPI) networks were created upon Cytoscape software. Additionally, VSCC with up-regulated expression of these key molecules exhibited a significantly decreased TME immune cell infiltration. SYCP2 is overexpressed in HPV + VSCC and could be a candidate therapy target for further research.IMPACT STATEMENT<b>What is already known on this subject?</b> VSCC are characterised by two aetiological pathways. The former occurs in the background of lichen sclerosus, while the latter is related to HPV infection. VSCC most commonly arises from the non-HPV related pathway portends worse prognosis than VSCC derived from HPV infection.<b>What do the results of this study add?</b> Five key molecules are identified and significantly up-regulated in HPV + VSCC. In which, SYCP2 is overexpressed in HPV + VSCC and exhibited a significantly decreased TME immune cell infiltration. SYCP2 constant expression could be a potential biomarker of neoplasms associated with HPV and could be a candidate therapy target in VSCC especially HPV + VSCC for further research.<b>What are the implications of these findings for clinical practice and/or further research?</b> SYCP2 could be a candidate therapy target in VSCC especially with HPV + for further research. <b>What is already known on this subject?</b> VSCC are characterised by two aetiological pathways. The former occurs in the background of lichen sclerosus, while the latter is related to HPV infection. VSCC most commonly arises from the non-HPV related pathway portends worse prognosis than VSCC derived from HPV infection. <b>What do the results of this study add?</b> Five key molecules are identified and significantly up-regulated in HPV + VSCC. In which, SYCP2 is overexpressed in HPV + VSCC and exhibited a significantly decreased TME immune cell infiltration. SYCP2 constant expression could be a potential biomarker of neoplasms associated with HPV and could be a candidate therapy target in VSCC especially HPV + VSCC for further research. <b>What are the implications of these findings for clinical practice and/or further research?</b> SYCP2 could be a candidate therapy target in VSCC especially with HPV + for further research.
DOI: 10.6084/m9.figshare.21941503.v1
title: Identification of potential prognostic biomarkers in vulval squamous cell carcinoma based on human papillomavirus infection Status-Analysis of GSE183454

description: This study aimed to elucidate the differences in vulval squamous cell carcinomas (VSCC) based on the HPV infection status. The sequencing data GSE183454 which contains 23 VSCC samples based on its HPV infection status was obtained from the Gene Expression Omnibus (GEO) database. We comprehensively dissected the differences of genomic and tumour microenvironment (TME) immune cell infiltration landscapes between HPV + and HPV- VSCC. The potential molecular mechanisms of prognostic genes were explored by functional enrichment analysis. Five novel key molecules (SYCP2, SMC1B, RNF212, MAJIN and C14orf39) with significantly up-regulated expression in HPV + VSCC were identified while protein-protein interaction (PPI) networks were created upon Cytoscape software. Additionally, VSCC with up-regulated expression of these key molecules exhibited a significantly decreased TME immune cell infiltration. SYCP2 is overexpressed in HPV + VSCC and could be a candidate therapy target for further research.IMPACT STATEMENT<b>What is already known on this subject?</b> VSCC are characterised by two aetiological pathways. The former occurs in the background of lichen sclerosus, while the latter is related to HPV infection. VSCC most commonly arises from the non-HPV related pathway portends worse prognosis than VSCC derived from HPV infection.<b>What do the results of this study add?</b> Five key molecules are identified and significantly up-regulated in HPV + VSCC. In which, SYCP2 is overexpressed in HPV + VSCC and exhibited a significantly decreased TME immune cell infiltration. SYCP2 constant expression could be a potential biomarker of neoplasms associated with HPV and could be a candidate therapy target in VSCC especially HPV + VSCC for further research.<b>What are the implications of these findings for clinical practice and/or further research?</b> SYCP2 could be a candidate therapy target in VSCC especially with HPV + for further research. <b>What is already known on this subject?</b> VSCC are characterised by two aetiological pathways. The former occurs in the background of lichen sclerosus, while the latter is related to HPV infection. VSCC most commonly arises from the non-HPV related pathway portends worse prognosis than VSCC derived from HPV infection. <b>What do the results of this study add?</b> Five key molecules are identified and significantly up-regulated in HPV + VSCC. In which, SYCP2 is overexpressed in HPV + VSCC and exhibited a significantly decreased TME immune cell infiltration. SYCP2 constant expression could be a potential biomarker of neoplasms associated with HPV and could be a candidate therapy target in VSCC especially HPV + VSCC for further research. <b>What are the implications of these findings for clinical practice and/or further research?</b> SYCP2 could be a candidate therapy target in VSCC especially with HPV + for further research.
DOI: 10.17026/dans-xts-grze
title: Retranchement Prins Mauritsstraat - Dorpsstraat Retranchement Prins Mauritsstraat (SLU00K691) - Dorpsstraat (SLU00K53-SLU00K90). Gemeente Sluis. Archeologisch Bureauonderzoek en Inventariserend Veldonderzoek door middel van verkennende boringen

description: &lt;p&gt;Het voornemen is om de riolering in de Prins Mauritsstraat en een deel van de Dorpsstraat in het centrum van Retranchement te vernieuwen. Er wordt een gescheiden stelsel aangelegd en de openbare ruimte wordt opnieuw ingericht. In het kader van de hiertoe benodigde omgevingsvergunning heeft Artefact! Advies en Onderzoek in Erfgoed een archeologisch vooronderzoek uitgevoerd.&lt;/p&gt;&lt;p&gt;Dit onderzoek bestond in eerste instantie uit een bureauonderzoek waarbij een gespecificeerd verwachtingsmodel werd opgesteld voor het plangebied. Dit model is vervolgens getoetst door het uitvoeren van een inventariserend veldonderzoek door middel van boringen (verkennende fase). Tijdens deze verkennende fase werden de landschappelijke vormeenheden bepaald met als doel kansarme zones uit te sluiten en kansrijke zones aan te duiden voor eventuele volgende vormen van onderzoek. Op basis van de resultaten van dit onderzoek kan gesteld worden dat: - In het oosten van het plangebied ter plaatste van de boringen 9 en 10 op een diepte vanaf 0,65 m -mv/ vanaf 1,15 m +NAP een middelhoge verwachting geldt op het voorkomen van vindplaatsen uit de Late Middeleeuwen en vroege Nieuwe Tijd, met name massief roodbakkend puin (boring 9) en een leef- of erflaag (boring 10) die zich beiden onmiddellijk bovenop het niveau van het Laagpakket van Walcheren bevinden.&lt;br&gt;- In de rest van het plangebied voor het niveau van het Laagpakket van Walcheren en de erboven gelegen antropogene ophooglagen een lage verwachting geldt voor vindplaatsen uit de Late Middeleeuwen en Nieuwe Tijd.&lt;/p&gt;
DOI: 10.17026/dans-xtt-xz4m
title: Enkco terrein Archeologisch proefsleuvenonderzoek op het Enkco-terrein te Holten.

description: &lt;p&gt;In opdracht van de gemeente Rijssen-Holten heeft Archol bv op 10 en 11 januari 2024 een archeologisch proefsleuvenonderzoek (IVO-p) uitgevoerd op het voormalige bedrijventerrein Enkco. Aanleiding voor het onderzoek is het voornemen van de gemeente om het plangebied te herontwikkelen.&lt;br&gt;Op basis van het uitgevoerde aanvullende bureau- en booronderzoek is in de deelgebieden Weverstraat en Industriestraat / Kolweg in verschillende boringen een plaggendek aangetroffen met daaronder een aangeploegde C-horizont.1 Het oorspronkelijke leefniveau is zeer waarschijnlijk wel aangetast maar archeologische grondsporen kunnen nog wel verwacht worden. Op basis hiervan is een gespecificeerde verwachting opgesteld, waarbij voor het onderzoeksgebied een hoge verwachting voor resten uit het laat neolithicum is vastgesteld. Voor de zuidrand van het deelgebied industriestraat Kolweg geldt tevens een hoge verwachting op resten uit de Nieuwe tijd.&lt;br&gt;De gemeente Holten-Rijssen heeft in haar rol als bevoegd gezag besloten dat vervolgonderzoek in de vorm van een waarderend proefsleuvenonderzoek noodzakelijk was.&lt;br&gt;Doel van het proefsleuvenonderzoek is het vaststellen van de aan- of afwezigheid van archeologische vindplaatsen op het terrein. Van eventuele vindplaatsen dient de aard, omvang, datering, gaafheid, conservering en inhoudelijke kwaliteit vastgesteld te worden.&lt;br&gt;De profielen in het westen en zuiden laten zien dat er binnen het onderzoeksgebied op de stuwwal oorspronkelijk een (deels) intacte holtpodzolbodem is gevormd. Vanaf de late-middeleeuwen heeft plaggenbemesting plaatsgevonden en heeft zich een esdek gevormd en is het terrein mogelijk verkaveld.&lt;br&gt;In het noordwesten van het onderzoeksgebied is een gedeelte van een huisplattegrond blootgelegd. De sporen zijn aangetroffen in het grindige zand van de stuwwal. Uit de sporen is geen dateerbaar materiaal verzameld waardoor de ouderdom vooralsnog onbekend blijft. De diepteligging en het voorkomen van de sporen doen vermoeden dat het nederzettingssporen uit de prehistorie of vroege middeleeuwen betreft.&lt;br&gt;In het zuiden van het onderzoeksgebied zijn sporen aangetroffen die op basis van het aardewerk dateren in de late middeleeuwen tot en met de Nieuwe tijd. Een aantal van deze sporen werd direct onder de recente bouwvoor al zichtbaar wat deze jonge datering ondersteund. Het betreft waarschijnlijk sporen van een boeren erf. De boerderij van dit erf heeft mogelijk langs de huidige Kolweg gestaan.&lt;br&gt;Op basis van de verspreiding van de sporen zijn twee vindplaatsen gedefinieerd (1 en 2). Archol acht beide vindplaatsen behoudenswaardig en adviseren behoud ‘in situ’. Mocht dit niet mogelijk zijn, dienen de vindplaatsen middels een opgraving ‘ex situ’ bewaard te blijven.&lt;/p&gt;
DOI: 10.6084/m9.figshare.22578690
title: Highly expressed circ_0000285 from serum and cervical exfoliated cells as a novel biomarker for the diagnosis of early stage-cervical cancer

description: Circ_0000285 is reported to play an oncogenic role in the development of cervical cancer (CC). The aim of this research was to investigate the diagnostic power of circ_0000285 in CC. The expression of circ_0000285 in 116 healthy volunteers, 65 early-stage CC (ESCC) patients, and 87 locally advanced CC (LACC) patients was detected by qRT-PCR. The diagnostic values of circ_0000285 for CC and ESCC were evaluated by ROC curves analysis. The circ_0000285 expression was upregulated in serum and cervical exfoliated cells from preoperative CC patients compared to that of healthy volunteers. Increased circ_0000285 expression was found in preoperative LACC patients more than that in ESCC patients. The circ_0000285 expression was downregulated in serum from CC patients after surgery. The postoperative CC patients with high serum circ_0000285 expression was more prone to have a tumour relapse. High circ_0000285 expression was positively correlated with SCC-Ag level and HPV positive rate. The AUC of circ_0000285 for the diagnosis of CC and ESCC were 0.855 and 0.804, better than CA125 and SCC-Ag. When circ_0000285, CA125, SCC-Ag and HPV were combined, the AUC could reach 0.911 and 0.894. In summary, highly expressed circ_0000285 from serum and cervical exfoliated cells might be a promising diagnostic biomarker for ESCC.Impact statement<b>What is already known on this subject?</b> The CA125 and SCC-Ag have limitations in the diagnosis of ESCC. Recently, circRNAs have caused great attention and have been developing rapidly in clinical diagnosis of malignant tumours.<b>What do the results of this study add?</b> Highly expressed circ_0000285 from serum and cervical exfoliated cells might be used as a novel, non-invasive biomarker for the diagnosis of ESCC.<b>What are the implications of these findings for clinical practice and/or further research?</b> Circ_0000285 is superior to CA125 and SCC-Ag for the diagnosis of ESCC in clinical practice. The results help to supplement the shortcomings of traditional tumour markers and improve the diagnosis of ESCC. <b>What is already known on this subject?</b> The CA125 and SCC-Ag have limitations in the diagnosis of ESCC. Recently, circRNAs have caused great attention and have been developing rapidly in clinical diagnosis of malignant tumours. <b>What do the results of this study add?</b> Highly expressed circ_0000285 from serum and cervical exfoliated cells might be used as a novel, non-invasive biomarker for the diagnosis of ESCC. <b>What are the implications of these findings for clinical practice and/or further research?</b> Circ_0000285 is superior to CA125 and SCC-Ag for the diagnosis of ESCC in clinical practice. The results help to supplement the shortcomings of traditional tumour markers and improve the diagnosis of ESCC.