cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.25442/hku.19918951
title: Supporting data for "Role of STING in MSC senescence"

description: This dataset contains raw data for the thesis "Role of STING in MSC senescence." <br> Mesenchymal stem cells (MSC) are a population of stem cells that possess a strong capacity for self-renewal, differentiation, and immunoregulation. Due to its easy accessibility and powerful potential, MSC has been considered a promising therapeutic reagent for various diseases. By 2020, there are more than 1000 clinical trials registered exploring the clinical application of MSC, and around 10 commercial MSC products have been approved. However, most of the clinical trials failed to meet the primary therapeutic end point in their late stage. Compromised therapeutic efficacy resulted from properties alteration and function loss of MSC can be induced by multiple factors in the process of MSC transplantation, including cellular senescence. Cellular senescence is a process which elicits upon various insults, resulting in a series of alterations such as morphology changes, chromatin rearrangement and metabolic reprogramming. During senescence, cells could secret a wide range of cytokines, chemokines and proteinases termed senescence-associated secretory phenotype (SASP), which could pose an effect on the senescent cells and the microenvironment and accelerate the senescence process in turn. MSC senescence has been reported to be observed in those cells isolated from elder donors and harvested from long period expansion in vitro. In addition, MSCs can also grow senescence in inflammation environment, which may help explain the short duration of MSC after transplanted into recipients. Since the immunomodulatory properties of MSC are exerted through soluble mediators, the senescence of MSC can greatly impair its function in immunosuppression. Due to the prominent effect of MSC senescence on its function and therapeutic efficacy after transplantation, it is essential to monitor senescence and understand the underlying mechanism of this process. Recent studies demonstrated that STING pathway was activated during senescence, mediating the type I interferon secretion and SASP response. However, most of the experiments were performed in MEF cells or fibroblast cells. Thus, we aimed to explore the role of STING pathway in MSC senescence and how this process may contribute to improve the therapeutic efficacy of MSCs transplantation. <br> This dataset consists of the results of the experiments involved in this thesis, including Western Blotting, Immunofluorescence staining, MTT assay, SA-β-gal staining, and flow cytometry. All mice models and results were included.
DOI: 10.25442/hku.19918951.v1
title: Supporting data for "Role of STING in MSC senescence"

description: This dataset contains raw data for the thesis "Role of STING in MSC senescence." <br> Mesenchymal stem cells (MSC) are a population of stem cells that possess a strong capacity for self-renewal, differentiation, and immunoregulation. Due to its easy accessibility and powerful potential, MSC has been considered a promising therapeutic reagent for various diseases. By 2020, there are more than 1000 clinical trials registered exploring the clinical application of MSC, and around 10 commercial MSC products have been approved. However, most of the clinical trials failed to meet the primary therapeutic end point in their late stage. Compromised therapeutic efficacy resulted from properties alteration and function loss of MSC can be induced by multiple factors in the process of MSC transplantation, including cellular senescence. Cellular senescence is a process which elicits upon various insults, resulting in a series of alterations such as morphology changes, chromatin rearrangement and metabolic reprogramming. During senescence, cells could secret a wide range of cytokines, chemokines and proteinases termed senescence-associated secretory phenotype (SASP), which could pose an effect on the senescent cells and the microenvironment and accelerate the senescence process in turn. MSC senescence has been reported to be observed in those cells isolated from elder donors and harvested from long period expansion in vitro. In addition, MSCs can also grow senescence in inflammation environment, which may help explain the short duration of MSC after transplanted into recipients. Since the immunomodulatory properties of MSC are exerted through soluble mediators, the senescence of MSC can greatly impair its function in immunosuppression. Due to the prominent effect of MSC senescence on its function and therapeutic efficacy after transplantation, it is essential to monitor senescence and understand the underlying mechanism of this process. Recent studies demonstrated that STING pathway was activated during senescence, mediating the type I interferon secretion and SASP response. However, most of the experiments were performed in MEF cells or fibroblast cells. Thus, we aimed to explore the role of STING pathway in MSC senescence and how this process may contribute to improve the therapeutic efficacy of MSCs transplantation. <br> This dataset consists of the results of the experiments involved in this thesis, including Western Blotting, Immunofluorescence staining, MTT assay, SA-β-gal staining, and flow cytometry. All mice models and results were included.
DOI: 10.25442/hku.19929725
title: Supporting data for “Elucidating the Pathogenesis of Enterovirus A71 Infection Using a Multi-omics Approach”

description: Enterovirus A71 (EV-A71) is an important human-pathogenic virus that causes hand, foot, and mouth disease (HFMD) outbreaks. Severe EV-A71 infection may be associated with neurological and cardiopulmonary complications which have a high mortality. However, the pathogenesis underlying these severe complications is not fully understood and effective antiviral treatment for EV-A71 infection is unavailable currently. Lipidomics and metabolomics applied in this study aimed to provide insights on EVA-71-induced changes on the host lipidome and metabolome and advance the knowledge of EV-A71 pathogenesis and the development of treatment strategy against EV-A71 infection. <br> The dataset is organized into two individual folders. Each of them includes all the dataset for the lipidomic and metabolic studies in my PhD thesis separately. The raw data of lipidomics, metabolomics, and RT-qPCR which contains name of samples, identified compounds, date of experiment, and treatments are reserved in the dataset. Other summarized data of experiments with different treatments are all shown in the dataset.
DOI: 10.25442/hku.19929725.v1
title: Supporting data for “Elucidating the Pathogenesis of Enterovirus A71 Infection Using a Multi-omics Approach”

description: Enterovirus A71 (EV-A71) is an important human-pathogenic virus that causes hand, foot, and mouth disease (HFMD) outbreaks. Severe EV-A71 infection may be associated with neurological and cardiopulmonary complications which have a high mortality. However, the pathogenesis underlying these severe complications is not fully understood and effective antiviral treatment for EV-A71 infection is unavailable currently. Lipidomics and metabolomics applied in this study aimed to provide insights on EVA-71-induced changes on the host lipidome and metabolome and advance the knowledge of EV-A71 pathogenesis and the development of treatment strategy against EV-A71 infection. <br> The dataset is organized into two individual folders. Each of them includes all the dataset for the lipidomic and metabolic studies in my PhD thesis separately. The raw data of lipidomics, metabolomics, and RT-qPCR which contains name of samples, identified compounds, date of experiment, and treatments are reserved in the dataset. Other summarized data of experiments with different treatments are all shown in the dataset.
DOI: 10.25442/hku.19932095
title: Supporting data for "Investigating the Development of University Students’ Leadership Skills Self-efficacy Beliefs During Collaborative Learning"

description: This dataset includes the quantitative and qualitative dataset for the thesis entitled "Investigating the Development of University Students’ Leadership Skills Self-efficacy Beliefs During Collaborative Learning" by Katherine KW Lee, for her degree of Doctor of Philosophy at The University of Hong Kong. <br> This study looks at students' transferable skills development, focusing specifically on leadership skills, and utilises Bandura's (1997) construct of self-efficacy to explore the ways in which students' leadership skills self-efficacy beliefs (LSSE) are formed and impacted during their various experiences, including during collaborative learning activities. <br> The dataset includes quantitative data (survey scale item responses) and qualitative data (survey open-ended questions, journal reflection responses, and individual interview transcripts).
DOI: 10.25442/hku.19932095.v1
title: Supporting data for "Investigating the Development of University Students’ Leadership Skills Self-efficacy Beliefs During Collaborative Learning"

description: This dataset includes the quantitative and qualitative dataset for the thesis entitled "Investigating the Development of University Students’ Leadership Skills Self-efficacy Beliefs During Collaborative Learning" by Katherine KW Lee, for her degree of Doctor of Philosophy at The University of Hong Kong. <br> This study looks at students' transferable skills development, focusing specifically on leadership skills, and utilises Bandura's (1997) construct of self-efficacy to explore the ways in which students' leadership skills self-efficacy beliefs (LSSE) are formed and impacted during their various experiences, including during collaborative learning activities. <br> The dataset includes quantitative data (survey scale item responses) and qualitative data (survey open-ended questions, journal reflection responses, and individual interview transcripts).
DOI: 10.34740/kaggle/dsv/3768258
title: BBC News
DOI: 10.5281/zenodo.6626349
title: Data_ANU_Jang et al.

description: Mortality and infection rate data.
DOI: 10.5281/zenodo.6626348
title: Data_ANU_Jang et al.

description: Mortality and infection rate data.
DOI: 10.6084/m9.figshare.16955847
title: Microalgal competence in urban wastewater management: phycoremediation and lipid production

description: The present study was conducted to assess the strain aptness, phycoremediation potential and lipid yield in microalgae <i>Chloroccocum humicola</i> and <i>Oscillatoria</i> sp. Results revealed that microalgae treated with different concentration of wastewater (25%, 50%, 75% and 100%) recovered nutrients (Nitrogen: 50.55–85.90%, Phosphorus: 69.98–93.72%) and removed heavy metals (24.17–88.10%) from wastewater. Microalgae <i>C. humicola</i> showed significant reduction in physico-chemical parameters of wastewater at 25% and 50% respectively with considerable increase in lipid production (1.61 folds) at 50% wastewater concentration. In order to counterbalance the wastewater induced toxicity, both microalgae exhibited stimulated antioxidants viz., proline (1.26–4.04 folds), ascorbic acid (1.01–9.21 folds), cysteine (1.44–4.92 folds), catalase (0.99–3.63 folds), superoxide dismutase (1.15–1.43 folds) and glutathione reductase (1.43–6.67 folds) at different wastewater concentrations. Further, Fourier transforms infrared spectroscopy spectral elucidation of <i>Chloroccocum humicola</i> at 50% reflected high lipid peak in the regions 3000–2800<b> </b>cm<sup>−1</sup> as compared to <i>Oscillatoria</i> sp. Thus, growth characteristics, biochemical responses and lipid yield presented the suitability of the <i>Chloroccocum humicola</i> to be used in phycoremedation, resource recovery as well as lipid production, which may be further utilized as potent feedstock for third generation energy demand.
DOI: 10.6084/m9.figshare.16955847.v1
title: Microalgal competence in urban wastewater management: phycoremediation and lipid production

description: The present study was conducted to assess the strain aptness, phycoremediation potential and lipid yield in microalgae <i>Chloroccocum humicola</i> and <i>Oscillatoria</i> sp. Results revealed that microalgae treated with different concentration of wastewater (25%, 50%, 75% and 100%) recovered nutrients (Nitrogen: 50.55–85.90%, Phosphorus: 69.98–93.72%) and removed heavy metals (24.17–88.10%) from wastewater. Microalgae <i>C. humicola</i> showed significant reduction in physico-chemical parameters of wastewater at 25% and 50% respectively with considerable increase in lipid production (1.61 folds) at 50% wastewater concentration. In order to counterbalance the wastewater induced toxicity, both microalgae exhibited stimulated antioxidants viz., proline (1.26–4.04 folds), ascorbic acid (1.01–9.21 folds), cysteine (1.44–4.92 folds), catalase (0.99–3.63 folds), superoxide dismutase (1.15–1.43 folds) and glutathione reductase (1.43–6.67 folds) at different wastewater concentrations. Further, Fourier transforms infrared spectroscopy spectral elucidation of <i>Chloroccocum humicola</i> at 50% reflected high lipid peak in the regions 3000–2800<b> </b>cm<sup>−1</sup> as compared to <i>Oscillatoria</i> sp. Thus, growth characteristics, biochemical responses and lipid yield presented the suitability of the <i>Chloroccocum humicola</i> to be used in phycoremedation, resource recovery as well as lipid production, which may be further utilized as potent feedstock for third generation energy demand.
DOI: 10.6084/m9.figshare.20033089
title: Evaluation of common bean morphological traits identifies grain thickness directly correlated with cooking time

description: ABSTRACT The development of new common bean cultivars with grain characteristics that achieve greater acceptance by consumers and faster cooking time is a recent trend in bean breeding programs. This study aimed at evaluating whether different common bean lines exhibit differences in grain morphological traits and cooking time, investigating the linear relationships between these traits and cooking time, and selecting lines with superior grain commercial characteristics and faster cooking times. A randomized blocks design with three replications was used. Treatments consisted of 14 common bean genotypes grown during two seasons. Differences in the mass of 100 grains and grain length, width, thickness, shape, flatness, percentage of water uptake and cooking time were observed between lines. A high positive correlation was observed between grain thickness and cooking time (r = 0.9727). The path analysis revealed that grain thickness had the highest positive direct effect on cooking time (0.62). Therefore, fast-cooking common bean lines can be indirectly selected based on lower grain thicknesses. The DF 06-17 line presents fast-cooking grains with characteristics well accepted by the market and consumers.
DOI: 10.6084/m9.figshare.20033089.v1
title: Evaluation of common bean morphological traits identifies grain thickness directly correlated with cooking time

description: ABSTRACT The development of new common bean cultivars with grain characteristics that achieve greater acceptance by consumers and faster cooking time is a recent trend in bean breeding programs. This study aimed at evaluating whether different common bean lines exhibit differences in grain morphological traits and cooking time, investigating the linear relationships between these traits and cooking time, and selecting lines with superior grain commercial characteristics and faster cooking times. A randomized blocks design with three replications was used. Treatments consisted of 14 common bean genotypes grown during two seasons. Differences in the mass of 100 grains and grain length, width, thickness, shape, flatness, percentage of water uptake and cooking time were observed between lines. A high positive correlation was observed between grain thickness and cooking time (r = 0.9727). The path analysis revealed that grain thickness had the highest positive direct effect on cooking time (0.62). Therefore, fast-cooking common bean lines can be indirectly selected based on lower grain thicknesses. The DF 06-17 line presents fast-cooking grains with characteristics well accepted by the market and consumers.
DOI: 10.6084/m9.figshare.19930586
title: Mass spectrometry of short peptides reveals common features of metazoan peptidergic neurons.

description: PAM_Alignment.docx: Alignment of PAM AA sequences. clsutalwPAM5_mv_TspLpAc_mvID.fa: Alignment of PAM AA sequences in FASTA format. cleavage_sites.xlsx: Statistics of AA found in the cleavage sites of peptide precursors (Figure 1f). Bmi_ykhm_S5_R1:B.mikado Illumina paired-end sequences R1 Bmi_ykhm_S5_R2:B.mikado Illumina paired-end sequences R2 Transcriptome.xlsx: statistics of transcriptome data Bmikykhm_trinity_out_dir.Trinity.fasta: Assembled transcriptome sequence file <code>Nv_umi_per_cluster: Nematostealla vectensis gene list, used to generate plots in Extended Figure 5, Extended Figure 6, and Supplementary Data 3. For each cell cluster, all genes with raw UMI count =&gt; 1 are reported.</code> <code>Ml_umi_per_cluster: Mnemiopsis leidyi gene list, used to generate plots in Figure 3, Figure 4f-g, Extended Figure 6, and Supplementary Data 3. For each cell cluster, all genes with raw UMI count =&gt; 1 are reported.</code> <code>Fig2: Raw data of fluorescent immunostaining of Bolinopsis mikado.</code> Fig4a-e: Raw dataset of Fig4a-e. Ex.fig3: Raw dataset of fluoroscent immunostaining of N. vectensis. <code>Ex.fig4: Raw data of fluorescent immunostaining of Vallicula multiformis.</code> <code>Supple.Fig6: Raw data of B. mikado NPWa immunostaining with and without primary antibody.</code> <code>Supple.Fig7: Raw data of V. multiformis VWYa immunostaining with and without primary antibody.</code>
DOI: 10.6084/m9.figshare.20033139
title: Additional file 2 of Transcriptional and post-transcriptional regulation of young genes in plants

description: Additional file 2: NGS data. Table S1. Mapping percentage of FAIRE-seq and RNA-seq data. Table S2. Expression of young and old genes in rice seedlings.
DOI: 10.6084/m9.figshare.20033139.v1
title: Additional file 2 of Transcriptional and post-transcriptional regulation of young genes in plants

description: Additional file 2: NGS data. Table S1. Mapping percentage of FAIRE-seq and RNA-seq data. Table S2. Expression of young and old genes in rice seedlings.
DOI: 10.6084/m9.figshare.20033214
title: Additional file 4 of Mapping the global distribution of Strongyloides stercoralis and hookworms by ecological niche modeling

description: Additional file 4: Total_data: csv file with the longitude, latitude, PP (for each species), country identification and population number for each pixel of the hookworm and S. stercoralis ecological niche models.
DOI: 10.6084/m9.figshare.20033214.v1
title: Additional file 4 of Mapping the global distribution of Strongyloides stercoralis and hookworms by ecological niche modeling

description: Additional file 4: Total_data: csv file with the longitude, latitude, PP (for each species), country identification and population number for each pixel of the hookworm and S. stercoralis ecological niche models.
DOI: 10.6084/m9.figshare.20033235
title: Additional file 7 of Mapping the global distribution of Strongyloides stercoralis and hookworms by ecological niche modeling

description: Additional file 7: asc file S. stercoralis_Niche_Raster_map.
DOI: 10.6084/m9.figshare.20033235.v1
title: Additional file 7 of Mapping the global distribution of Strongyloides stercoralis and hookworms by ecological niche modeling

description: Additional file 7: asc file S. stercoralis_Niche_Raster_map.
DOI: 10.6084/m9.figshare.20033238
title: Additional file 8 of Mapping the global distribution of Strongyloides stercoralis and hookworms by ecological niche modeling

description: Additional file 8: asc file HKW_Niche_Raster_Map.
DOI: 10.6084/m9.figshare.20033238.v1
title: Additional file 8 of Mapping the global distribution of Strongyloides stercoralis and hookworms by ecological niche modeling

description: Additional file 8: asc file HKW_Niche_Raster_Map.
DOI: 10.6084/m9.figshare.20025884
title: partial raw dataset of mass spectrometry-based peptide identification and related work

description: partial raw dataset related neuropeptide identification in basal metazoans
DOI: 10.6084/m9.figshare.20025884.v2
title: partial raw dataset of mass spectrometry-based peptide identification and related work

description: partial raw dataset related neuropeptide identification in basal metazoans
DOI: 10.6084/m9.figshare.20025884.v1
title: test

description: test
DOI: 10.5517/ccdc.csd.cc29zb2q
title: CCDC 2144303: Experimental Crystal Structure Determination

description: Related Article: M.L. Davidson, S. Grabowsky, D. Jayatilaka|2022|Acta Crystallogr.,Sect.B:Struct.Sci.,Cryst.Eng. and Mat.|78|397|doi:10.1107/S2052520622004103
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.6084/m9.figshare.20033111
title: An experimental dataset of the equilibrium scour depth in sandy and silty seabeds beneath non-buried and half-buried pipelines under regular waves

description: This is an experimental dataset of the equilibrium scour depth in sandy and silty seabeds beneath non-buried and half-buried pipelines under regular waves, which is analyzed in the paper "An optimal statistical regression model for predicting wave-induced equilibrium scour depth in sandy and silty seabeds beneath pipelines".
DOI: 10.6084/m9.figshare.20033111.v1
title: An experimental dataset of the equilibrium scour depth in sandy and silty seabeds beneath non-buried and half-buried pipelines under regular waves

description: This is an experimental dataset of the equilibrium scour depth in sandy and silty seabeds beneath non-buried and half-buried pipelines under regular waves, which is analyzed in the paper "An optimal statistical regression model for predicting wave-induced equilibrium scour depth in sandy and silty seabeds beneath pipelines".
DOI: 10.6084/m9.figshare.20033105
title: Figure 1.zip

description: <strong>Modulation of mesenchymal stem cells</strong> <strong>protection against senescence during</strong> <strong>long-term expansion by the PI3K/Akt signaling</strong>
DOI: 10.6084/m9.figshare.20033105.v1
title: Figure 1.zip

description: <strong>Modulation of mesenchymal stem cells</strong> <strong>protection against senescence during</strong> <strong>long-term expansion by the PI3K/Akt signaling</strong>
DOI: 10.5281/zenodo.6541955
title: The data of acp-2022-336

description: Data used in the work "Fluorescence characteristics, absorption properties, and radiative effects of water-soluble organic carbon in seasonal snow across northeastern China".
DOI: 10.6084/m9.figshare.20032988
title: The GWAS summaries of 21 agronomic traits in Simmental cattle

description: The genotyped with Illumina Bovine 770K Bead chip were imputed to sequence level using Beagle 5.4 based on a multiple-breed reference population consisted of 1,847 individuals from run 8 of the 1000 Bull Genomes Project. A total of 8.2 million SNPs (MAF &gt; 5% and missing rate &lt; 10%) for 854 ~2,622 individuals were used to perform the genome-wide association analysis. Before running the GWAS, the phenotype were adjusted for year, sex, age (month), and the first two principal components produced by PLINK and normalized by rank-transformation separately using the transform function included in the GenABEL. The associations among SNPs and traits were tested using mixed linear models in GCTA software.