cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.5281/zenodo.4558651
title: Circulating carboxylated osteocalcin correlates with skeletal muscle mass and risk of fall in postmenopausal osteoporotic women

description: <em>Background </em>Bone and skeletal muscle represent a single functional unit. We cross-sectionally investigated body composition, risk of fall and circulating osteocalcin (OC) isoforms in osteoporotic postmenopausal women to test the hypothesis of an involvement of OC in the bone-muscle crosstalk. <em>Materials and methods </em>Twenty-nine non-diabetic, non-obese, postmenopausal osteoporotic women (age 72.4±6.8 years; BMI 23.0±3.3 kg/m2) underwent to: 1) fasting blood sampling for biochemical and hormone assays, including carboxylated (cOC) and uncarboxylated (uOC) osteocalcin; 2) whole-body dual energy X-ray absorptiometry (DXA) to assess total and regional body composition; 3) magnetic resonance imaging to determine cross-sectional muscle area (CSA) and intermuscular adipose tissue (IMAT) of thigh muscles; 4) risk of fall assessment through the OAK system. <em>Results </em>Appendicular skeletal muscle index (ASMMI) was low in 45% of patients. Forty percent got a low OAK score, consistent with moderate-severe risk of fall, which was predicted by low legs lean mass and increased total fat mass. Circulating cOC levels showed significantly correlated with CTx-I, lean mass parameters including IMAT, and OAK score. Fractured and unfractured women did not differ for any of the analyzed parameters, though cOC and uOC positively correlated with legs lean mass, OAK score and bone markers only in fractured women. <em>Conclusions </em>Data supported the relationship between OC and skeletal muscle mass and function in postmenopausal osteoporotic women. Serum cOC, but not uOC, emerges as mediator in the bone- muscle crosstalk. Circulating cOC and uOC levels may be differentially regulated in fractured and unfractured osteoporotic women, suggesting underlying differences in bone metabolism.
DOI: 10.5281/zenodo.4683021
title: The core stem genes SOX2, POU5F1/OCT4, and NANOG are expressed in human parathyroid tumors and modulated by MEN1, YAP1 and -catenin pathways activation.

description: Tumors of the parathyroid glands are the second most common endocrine neoplasia. Epigenetic studies revealed an embryonic signature involved in parathyroid tumorigenesis. Here we investigated the expression of the stem core genes SOX2, POU5F1/OCT4 and NANOG. Rare cells within normal parathyroid glands expressed POU5F1/OCT4 and NANOG, while SOX2 was undetectable. Nuclear SOX2 expression was detectable in 6 out of 34 (18%) parathyroid adenomas (PAds) involving 5-30% of cells, while OCT4 and NANOG were expressed at nuclear level in a more consistent subset of PAds involving 15-40% of cells. Most parathyroid carcinomas expressed the core stem genes. They were co-expressed in few PAds-derived cells, while SOX2-expressing cells co-expressed parathormone (PTH). In PAds-derived primary cultures (n=3), silencing of the tumor suppressor gene <em>MEN1</em> induced the expression of<em> SOX2</em>, while calcium-sensing receptor activation inhibited <em>SOX2</em> expression through YAP1 activation. Besides, inducing nuclear b-catenin accumulation in PAds-derived primary cultures (n=7) by short-term (8 hours) incubation with Lithium Chloride (LiCl, 10-20 mM), <em>SOX2</em> and <em>POU5F1/OCT4</em> expression levels increased, while <em>NANOG</em> transcripts were reduced; 72 hours with LiCl induced an opposite pattern of gene expression. In conclusion, detection of the cores stem genes in parathyroid tumors supports their embryogenic signature, which is modulated by crucial genes involved in parathyroid tumorigenesis.
DOI: 10.5281/zenodo.4683020
title: The core stem genes SOX2, POU5F1/OCT4, and NANOG are expressed in human parathyroid tumors and modulated by MEN1, YAP1 and -catenin pathways activation.

description: Tumors of the parathyroid glands are the second most common endocrine neoplasia. Epigenetic studies revealed an embryonic signature involved in parathyroid tumorigenesis. Here we investigated the expression of the stem core genes SOX2, POU5F1/OCT4 and NANOG. Rare cells within normal parathyroid glands expressed POU5F1/OCT4 and NANOG, while SOX2 was undetectable. Nuclear SOX2 expression was detectable in 6 out of 34 (18%) parathyroid adenomas (PAds) involving 5-30% of cells, while OCT4 and NANOG were expressed at nuclear level in a more consistent subset of PAds involving 15-40% of cells. Most parathyroid carcinomas expressed the core stem genes. They were co-expressed in few PAds-derived cells, while SOX2-expressing cells co-expressed parathormone (PTH). In PAds-derived primary cultures (n=3), silencing of the tumor suppressor gene <em>MEN1</em> induced the expression of<em> SOX2</em>, while calcium-sensing receptor activation inhibited <em>SOX2</em> expression through YAP1 activation. Besides, inducing nuclear b-catenin accumulation in PAds-derived primary cultures (n=7) by short-term (8 hours) incubation with Lithium Chloride (LiCl, 10-20 mM), <em>SOX2</em> and <em>POU5F1/OCT4</em> expression levels increased, while <em>NANOG</em> transcripts were reduced; 72 hours with LiCl induced an opposite pattern of gene expression. In conclusion, detection of the cores stem genes in parathyroid tumors supports their embryogenic signature, which is modulated by crucial genes involved in parathyroid tumorigenesis.
DOI: 10.5281/zenodo.4533868
title: Effect of Denosumab on Glucose Homeostasis in Postmenopausal Women with Breast Cancer Treated with Aromatase Inhibitors: A Pilot Study.

description: Raw Data Effect of Denosumab on Glucose Homeostasis in Postmenopausal Women with Breast Cancer Treated with Aromatase Inhibitors: A Pilot Study.
DOI: 10.5281/zenodo.4533867
title: Effect of Denosumab on Glucose Homeostasis in Postmenopausal Women with Breast Cancer Treated with Aromatase Inhibitors: A Pilot Study.

description: Raw Data Effect of Denosumab on Glucose Homeostasis in Postmenopausal Women with Breast Cancer Treated with Aromatase Inhibitors: A Pilot Study.
DOI: 10.5281/zenodo.4485746
title: Clinical, biochemical and genetic findings in adult patients with low bone mineral density and chronic hypophosphatasemia

description: Clinical, biochemical and genetic findings in adult patients with low bone mineral density and chronic hypophosphatasemia
DOI: 10.5281/zenodo.4485745
title: Clinical, biochemical and genetic findings in adult patients with low bone mineral density and chronic hypophosphatasemia

description: Clinical, biochemical and genetic findings in adult patients with low bone mineral density and chronic hypophosphatasemia
DOI: 10.21343/9p70-4q69
title: Sea ice drifter trajectories from the Arven Etter Nansen Physical Process Cruise 2018
DOI: 10.5281/zenodo.5341298
title: Investigation of CO2 Orientational Dynamics through Simulated NMR Line Shapes

description: Raw data set relating to publication.
DOI: 10.5281/zenodo.4905822
title: Investigation of CO2 Orientational Dynamics through Simulated NMR Line Shapes

description: Raw data set relating to publication.
DOI: 10.6084/m9.figshare.16553082.v1
title: Data: Non-Equilibrium Dynamics and Weakly Broken Integrability

description: Data required to produce plots shown in Non-Equilibrium Dynamics and Weakly Broken Integrability, and the associated supplemental material.
DOI: 10.15161/oar.it/74093
title: CovidStat project data

description: This record contains the daily updated data of the CovidStat project. CovidStat is a project carried out by the CovidStat Working Group at INFN, whose creation was promoted within the Italian National Institute of Nuclear Physics with the aim of making a statistical analysis of the data provided daily by the Civil Protection on the spread of the pandemic in Italy. CovidStat data can interactively be browsed at https://covid19.infn.it.
description: The software to process this Root TTree is in the related identifier. Be sure to use the right corresponding version, based on the data in which Root TTree was generated.
DOI: 10.6084/m9.figshare.16611739.v1
title: IPCC_WGII_Continental_Regions.zip

description: Continental regions used for the Cross-Chapter Paper on Mountains in the IPCC's 6th Assessment Report (Working Group II)
DOI: 10.6084/m9.figshare.16611739
title: IPCC_WGII_Continental_Regions.zip

description: Continental regions used for the Cross-Chapter Paper on Mountains in the IPCC's 6th Assessment Report (Working Group II)
DOI: 10.5281/zenodo.5506748
title: Test

description: lkklk hulfhulfglufugl
description: RB, ZALF
DOI: 10.5281/zenodo.5506747
title: Test

description: lkklk hulfhulfglufugl
description: RB, ZALF
DOI: 10.6084/m9.figshare.16616409
title: Code.m from Scalability of resonant motor-driven flapping wing propulsion systems

description: This work aims to develop an integrated conceptual design process to assess the scalability and performance of propulsion systems of resonant motor-driven flapping wing vehicles. The developed process allows designers to explore the interaction between electrical, mechanical and aerodynamic domains in a single transparent design environment. Wings are modelled based on a quasi-steady treatment that evaluates aerodynamics from geometry and kinematic information. System mechanics is modelled as a damped second order dynamic system operating at resonance with nonlinear aerodynamic damping. Motors are modelled using standard equations that relate operational parameters and AC voltage input. Design scaling laws are developed using available data based on current levels of technology. The design method provides insights into the effects of changing core design variables such as the actuator size, actuator mass fraction and pitching kinematics on the overall design solution. It is shown that system efficiency achieves peak values of 25–30% at motor masses of 0.5–1 g when a constant angle of attack kinematics is employed. While sinusoidal angle of attack kinematics demands more aerodynamic and electric powers compared to the constant angle of attack case, sinusoidal angle of attack kinematics leads to an increase of around 15% in the peak system efficiency.
DOI: 10.6084/m9.figshare.16616409.v1
title: Code.m from Scalability of resonant motor-driven flapping wing propulsion systems

description: This work aims to develop an integrated conceptual design process to assess the scalability and performance of propulsion systems of resonant motor-driven flapping wing vehicles. The developed process allows designers to explore the interaction between electrical, mechanical and aerodynamic domains in a single transparent design environment. Wings are modelled based on a quasi-steady treatment that evaluates aerodynamics from geometry and kinematic information. System mechanics is modelled as a damped second order dynamic system operating at resonance with nonlinear aerodynamic damping. Motors are modelled using standard equations that relate operational parameters and AC voltage input. Design scaling laws are developed using available data based on current levels of technology. The design method provides insights into the effects of changing core design variables such as the actuator size, actuator mass fraction and pitching kinematics on the overall design solution. It is shown that system efficiency achieves peak values of 25–30% at motor masses of 0.5–1 g when a constant angle of attack kinematics is employed. While sinusoidal angle of attack kinematics demands more aerodynamic and electric powers compared to the constant angle of attack case, sinusoidal angle of attack kinematics leads to an increase of around 15% in the peak system efficiency.
DOI: 10.17030/uclan.data.00000304
title: Primary Research Data for Analysing the Marketing Strategies for UK Fish Farming Businesses
DOI: 10.6084/m9.figshare.14757978
title: Evaluation of whole genome sequencing-based subtyping methods for the surveillance of Shigella spp. and the confounding effect of mobile genetic elements in long-term outbreaks

description: Supplementary Material for ‘Evaluation of whole genome sequencing-based subtyping methods for the surveillance of Shigella spp. and the confounding effect of mobile genetic elements in long-term outbreaks’ as published in <i>Microbial Genomics</i>.<br>
DOI: 10.6084/m9.figshare.14757978.v1
title: Evaluation of whole genome sequencing-based subtyping methods for the surveillance of Shigella spp. and the confounding effect of mobile genetic elements in long-term outbreaks

description: Supplementary Material for ‘Evaluation of whole genome sequencing-based subtyping methods for the surveillance of Shigella spp. and the confounding effect of mobile genetic elements in long-term outbreaks’ as published in <i>Microbial Genomics</i>.<br>
DOI: 10.5281/zenodo.5500088
title: Comprehensive discovery of CRISPR-targeted terminally redundant sequences in the human gut metagenome: viruses, plasmids, and more

description: S1 Data Dataset including the discovered CRISPR spacers, direct repeats, protospacers, co-occurrence-based spacer clustering results, predicted protein sequences, built HMMs, database comparison results, phylogenetic analysis results, predicted targeting hosts, and CRISPR-targeted TR sequences.
DOI: 10.6084/m9.figshare.16616299
title: Supplementary Material for: Limitations of SARC-F as a Screening Tool for Sarcopenia in Patients on Hemodialysis

description: <b><i>Introduction:</i></b> There are limited screening tools for sarcopenia in patients undergoing hemodialysis. This study aimed to investigate the reliability and validity of the SARC-F (Strength, Assistance in walking, Rise from a chair, Climb stairs, and Falls) questionnaire as a screening tool for sarcopenia (defined by the Asian Working Group for Sarcopenia [AWGS2019]) in patients undergoing hemodialysis. <b><i>Methods:</i></b> This cross-sectional study enrolled 179 patients (mean age: 66.5 ± 12 years, 58% men) undergoing maintenance hemodialysis 3 times per week at a hemodialysis center in Japan. The SARC-F score, handgrip strength, usual gait speed, sit-to-stand test time, short physical performance battery (SPPB), and appendicular skeletal muscle mass were evaluated. The reliability and validity of the SARC-F were analyzed using receiver-operating characteristic curve, area under the curve (AUC), and sensitivity/specificity analyses. <b><i>Results:</i></b> There were 49 (27.4%) patients with sarcopenia. Patients with SARC-F ≥4 (59 patients, 33.0%) had poorer grip strength, lower SPPB score, and slower gait speed than those with SARC-F &lt;4, while the skeletal muscle mass index did not differ significantly between the two groups. The sensitivity and specificity values of the SARC-F for identifying sarcopenia were 42.9% and 70.8%, respectively, while those for identifying severe sarcopenia were 66.7% and 72.3%, respectively. The AUCs of SARC-F were 0.57 for sarcopenia and 0.70 for severe sarcopenia. <b><i>Discussion/Conclusion:</i></b> The SARC-F alone is an inadequate screening tool for sarcopenia in patients undergoing hemodialysis. It should be used in combination with objective assessment measures, rather than as a first-step screening tool, to diagnose sarcopenia.
DOI: 10.6084/m9.figshare.15059799
title: Supplementary Material for: CART Peptides Differently Regulate Firing Rates and GABAergic Synaptic Inputs of DMV Neurons Innervating the Stomach Antrum and Cecum of Adult Male Rats

description: Medicine
DOI: 10.6084/m9.figshare.15059799.v1
title: Supplementary Material for: CART Peptides Differently Regulate Firing Rates and GABAergic Synaptic Inputs of DMV Neurons Innervating the Stomach Antrum and Cecum of Adult Male Rats

description: Medicine
DOI: 10.6084/m9.figshare.16616326
title: Supplementary Material for: Temporal Trends in the Severity and Mortality of Neonatal Hypoxic-Ischemic Encephalopathy in the Era of Hypothermia

description: <b><i>Introduction:</i></b> There is a paucity of studies examining temporal trends in the incidence and mortality of moderate-to-severe hypoxic-ischemic encephalopathy (HIE) during the last decade of therapeutic hypothermia (TH). <b><i>Methods:</i></b> Multicenter cross-sectional study of all infants ≥35 weeks gestational age diagnosed with moderate-to-severe HIE within 6 h of birth in an extensive region of Spain between 2011 and 2019, in order to detect trend changes over time in the (1) annual incidence, (2) severity of neurological and systemic organ involvement, and (3) neonatal death from HIE. <b><i>Results:</i></b> Annual incidence rate of moderate-to-severe HIE was 0.84 (95% confidence interval [CI] 0.7–0.97) per 1,000 births, without trend changes over time (<i>p</i> = 0.8), although the proportion of severe HIE infants showed an average annual decline of 0.86 points (95% CI 0.75–0.98). There were 102 (70%) infants diagnosed with moderate HIE and 44 (30%) with severe HIE. TH was offered to 139/146 (95%) infants. Infants with clinical and/or electrical seizures showed a decreasing trend from 56 to 28% (<i>p</i> = 0.006). Mortality showed a nonstatistically significant decline (<i>p</i> = 0.4), and the severity of systemic damage showed no changes (<i>p</i> = 0.3). Obstetric characteristics remained unchanged, while higher perinatal pH values (<i>p</i> = 0.03) and Apgar scores (<i>p</i> = 0.05), and less need for resuscitation (<i>p</i> = 0.07), were found over time. <b><i>Conclusion:</i></b> The annual incidence of moderate-to-severe HIE has stabilized at around 1 per 1,000 births, with a temporal trend toward a decrease in severe HIE infants and a slight decline of mortality. No association was found between temporal trends and changes in perinatal/obstetric characteristics over time.
DOI: 10.5519/qd.xo6oae47
title: Query on the Natural History Museum Data Portal (data.nhm.ac.uk) (1001 records)
DOI: 10.5519/qd.blypv687
title: Query on the Natural History Museum Data Portal (data.nhm.ac.uk) (997 records)
DOI: 10.6084/m9.figshare.12477563
title: Tasmanian devil (Sarcophilus harrisii) whisker growth, position and length data by Attard et al. 2021

description: The R script and data used in Attard <i>et al.</i> 2021 "Whisker growth in Tasmanian devils (<i>Sarcophilus harrisii</i>) and applications for stable isotope studies" published in the journal <i>Ecosphere</i>. Descriptions of each file are provided below.<br><b><br></b><b>R script: </b><b>Tasmanian devil vibrissae growth rate and length</b>This R script contains all code used to analyse data and create figures for the manuscript. The script uses Tasmanian devil whisker growth rate and length data available in csv files 1 to 3. <br><b>File 1: Tasmanian devil stable isotope whisker growth data</b><br><br>Stable isotope data for the longest facial whisker taken from six captive Tasmanian devils. A single whisker was taken per individual. Each whisker was cut into sections starting from the follicle (base) using a scalpel. The sections were standardised to weigh between 0.6 to 0.8 mg (2-8 mm length). The length of each whisker segment was recorded. The base of the whisker represents the date the whisker was removed, and peaks in nitrogen stable isotope values represent separate isotope labelling events, whereby animals were fed enriched isotope-labelled glycine (99% for carbon and 98% for nitrogen). These peaks were used to calculate the increase in whisker length over a unit of time.<br><b>File 2: Tasmanian devil whisker position and length data</b><br>Raw data for intradermal, extradermal and total length of whiskers taken from 13 Tasmanian devils used to assess the arrangement and relative length of mystacial whiskers on the face. Whisker length was taken at all positions on the left and right side of the face for each individual.<br><b>File 3: Asymptotic whisker length of wild Tasmanian devils</b><b><br></b>Raw data used to measure asymptotic length (L<sub>a</sub>) of the longest whisker collected from 617 live wild Tasmanian devils. For each position, estimated intradermal length is the mean intradermal length of 13 preserved Tasmanian devils (see File 2). Extradermal length is the length of the longest whisker cut from live wild Tasmanian devils. Estimated total length is the sum of estimated intradermal length and measured extradermal length of the longest whisker. Asymptotic length is the estimated total length + 1% of the estimated total length.<br><b>File 4: </b><b>Tasmanian devil average growth rate with root estimate</b>Average whisker growth rate is exported from the R script as a csv file. File 3 updates the total length of the whisker for two specimens with whiskers that were cut rather than plucked for the captive stable isotope study by adding the estimated intradermal root length (3.8 mm) of Tasmanian devil whiskers.
DOI: 10.5281/zenodo.5501388
title: Synthetic data set to evaluate and benchmark the performance of multiple linear regression algorithms in Scikit-Learn and SANElib

description: The datasets respresent different numbers of columns and rows to measure the scalability of linear regression algorihms in terms of columns and rows.
DOI: 10.5281/zenodo.5354981
title: Synthetic data set to evaluate and benchmark the performance of multiple linear regression algorithms in Scikit-Learn and SANElib

description: The datasets respresent different numbers of columns and rows to measure the scalability of linear regression algorihms in terms of columns and rows.
DOI: 10.5519/qd.nbf1xmxa
title: Query on the Natural History Museum Data Portal (data.nhm.ac.uk) (269 records)
DOI: 10.25646/9026
title: Tagesdaten-CSV aus dem DIVI-Intensivregister

description: Die Tagesdaten-CSV entspricht einem Auszug der Daten des DIVI-Intensivregisters. Die Datei enthält eine Aggregation der aktuellsten Meldungen pro Landkreis. Es werden die aktuell gemeldeten Anzahlen der COVID-19 Intensivfälle sowie die gemeldeten intensivmedizinischen Behandlungskapazitäten angezeigt. Die Tagesdaten-CSV liefert dabei ausschließlich einen Blick auf die Daten gemäß dem Stand des betrachteten Tages. Die Daten sind im situationsbedingten Kontext aufbereitet, damit sind verschiedene Tagesdaten-CSVs u.U. nicht direkt miteinander vergleichbar. Die aktuellsten Meldungen werden im gewählten Betrachtungszeitfenster über alle Meldebereiche und Standorte aufsummiert. Weitere Informationen sind zu finden unter https://www.intensivregister.de/#/faq
DOI: 10.5281/zenodo.5506919
title: Ontogenetic changes in the tooth morphology of bull sharks (Carcharhinus leucas)

description: Teeth are an integral component of feeding ecology with a clear link between tooth morphology and diet, as without suitable dentition prey cannot be captured nor broken down for consumption. Bull sharks <em>Carcharhinus leucas</em> undergo an ontogenetic niche shift from freshwater to marine habitats, which raises the question: does tooth morphology change with ontogeny? Tooth shape, surface area and thickness were measured using both traditional morphometrics and an Elliptic Fourier Analysis, to determine if morphology varied with position in the jaw and if there was an ontogenetic change concordant with this niche shift. Significant ontogenetic differences in tooth morphology as a function of position in the jaw and shark total length were found, with upper and lower jaws of bull sharks presenting two different tooth morphologies. Tooth shape and thickness fell into two groupings, anterior and posterior, in both the upper and lower jaws. Tooth surface area, however, indicated three groupings, mesial, intermediate and distal, in both the upper and lower jaws. While tooth morphology changed significantly with size, showing an inflexion at sharks of 135 cm total length, each morphological aspect retained the same tooth groupings throughout. These ontogenetic differences in tooth morphologies reflect tooth strength, prey handling and heterodonty.