cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.5286/isis.e.rb2310176
title: Effect of aggregation states of Aβ42-Monomer and Fibril on the Dynamics of a Neuronal Model Membrane

description: Amyloid Aβ (1-42), Aβ42 is predominantly found in the form of plaques in the brain tissues in Alzheimer's disease. Studies have shown that Aβ42 plaques are mainly responsible for cognitive dysfunctionality in Alzheimer’s. Aβ42 exist in different aggregation states namely monomer (M), β-sheets, oligomer (O), or fibril (F). Studies have shown that the incorporation of amyloid, depending upon the amino acid length and aggregation states, can affect the phospholipid membrane distinctively. This can lead to structural and dynamic changes in the membrane and hence can affect membrane functions. Therefore, it is essential to investigate the effect of the aggregation states of Aβ42 on the dynamics and physiological relevant neuronal phospholipid membrane extracted from mammalian brain tissues on the picosecond time scale. This study can be useful to understand amyloid membrane interaction and add to our understanding of Alzheimer's disease. Here, we wish to investigate the effect of aggregation states of human Aβ42, a neurotoxic peptide, monomer (M) and fibril (F) on the dynamics of neuronal phospholipid membrane extracted from mammalian brain tissues
DOI: 10.5286/isis.e.rb2310176-1
title: Effect of aggregation states of Aβ42-Monomer and Fibril on the Dynamics of a Neuronal Model Membrane

description: Amyloid Aβ (1-42), Aβ42 is predominantly found in the form of plaques in the brain tissues in Alzheimer's disease. Studies have shown that Aβ42 plaques are mainly responsible for cognitive dysfunctionality in Alzheimer’s. Aβ42 exist in different aggregation states namely monomer (M), β-sheets, oligomer (O), or fibril (F). Studies have shown that the incorporation of amyloid, depending upon the amino acid length and aggregation states, can affect the phospholipid membrane distinctively. This can lead to structural and dynamic changes in the membrane and hence can affect membrane functions. Therefore, it is essential to investigate the effect of the aggregation states of Aβ42 on the dynamics and physiological relevant neuronal phospholipid membrane extracted from mammalian brain tissues on the picosecond time scale. This study can be useful to understand amyloid membrane interaction and add to our understanding of Alzheimer's disease. Here, we wish to investigate the effect of aggregation states of human Aβ42, a neurotoxic peptide, monomer (M) and fibril (F) on the dynamics of neuronal phospholipid membrane extracted from mammalian brain tissues
DOI: 10.5286/isis.e.rb2510186
title: Crystal field excitations in a triangular-lattice quantum spin liquid material RbNdSe2

description: RbNdSe2 is a new, previously unexplored species of a recently discovered large family of quantum spin liquid candidates with delafossite structure. We propose to use inelastic neutron scattering to study the crystal field excitations and determine the wavefunction of the ground state Kramer’s doublets and the magnetic anisotropy. The results are essential for understanding the novel low-energy spin dynamics due to correlations.
DOI: 10.3535/6g6-ynw-2d8
title: Senecio jacobaea L.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/6qm-rs1-sal
title: Lagenophora hirsuta Poepp. ex Less.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.5286/isis.e.rb1670521-3
title: mSR study of the chiral superconductivity in the honeycomb-lattice superconducting single crystals
DOI: 10.5286/isis.e.rb2420455
title: Neutron Reflectivity Study of Extrcellular Vesicles fusion with Lipid Membrane

description: The goal of the proposal is to perform neutron reflectivity experiment to study the mechanism of lipid membrane fusion with fibroin nanoparticles encapsulated into extracellular vesicles for designing systems for delivery of anticancer drugs to mesothelloma cells. We developed a novel multicompartment delivery systems, in which cytotoxic drug is encapsulated into fibroin nanoparticles with outer lipid shell. The lipid shell was modified by extracelluar vesicles in order to improve tagreting and transport properties of the nanovectors. However, the mechanism of fusion, the arrangement of the lipids in the membrane after fusion, and the effect of protein corona on fusion remain unclear, that is crucial to optimize shell composition for efficient drug delivery and release. We will study the arrangement of the lipids and proteins in the membrane after fusion of extracellular vesicles with encapsulated silk fibroin nanoparticles and model lipid membrane by neutron reflectivity with contrast variation using deuterated and protonated lipids and by varying H2O-to-D2O ratio.
DOI: 10.5286/isis.e.rb2420455-1
title: Neutron Reflectivity Study of Extrcellular Vesicles fusion with Lipid Membrane

description: The goal of the proposal is to perform neutron reflectivity experiment to study the mechanism of lipid membrane fusion with fibroin nanoparticles encapsulated into extracellular vesicles for designing systems for delivery of anticancer drugs to mesothelloma cells. We developed a novel multicompartment delivery systems, in which cytotoxic drug is encapsulated into fibroin nanoparticles with outer lipid shell. The lipid shell was modified by extracelluar vesicles in order to improve tagreting and transport properties of the nanovectors. However, the mechanism of fusion, the arrangement of the lipids in the membrane after fusion, and the effect of protein corona on fusion remain unclear, that is crucial to optimize shell composition for efficient drug delivery and release. We will study the arrangement of the lipids and proteins in the membrane after fusion of extracellular vesicles with encapsulated silk fibroin nanoparticles and model lipid membrane by neutron reflectivity with contrast variation using deuterated and protonated lipids and by varying H2O-to-D2O ratio.
DOI: 10.3535/8s5-242-v51
title: Berberidopsis corallina Hook. fil.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/xna-teg-61q
title: Erysimum cheiranthoides L.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.5286/isis.e.rb2420036
title: Catalytic dehydration of model molecule of bio-oil to produce hydroxymethylfurfural: a potential carbon-neutral intermediate for the synthesis of biofuels and chemicals

description: Hydroxymethylfurfural (HMF) an intermediate used in the production of a broad spectrum of biofuels and chemicals, such as polyester containing furanic compounds, polyamides, polyurethanes, pharmaceuticals and organic derivatives. In this context, the dehydration of frutose and glucose using acid catalysts can be an environmentally friendly synthesis route of HMF. In this proposal, we intend to contribute to increasing knowledge about the mechanism of the catalytic dehydration reaction of glucose in Beta zeolite-based catalysts. More specifically, we will try to differentiate the roles of Brønsted and Lewis acid sites during the reaction, which will be done through Inelastic Neutron Scattering (INS) experiments on the TOSCA instrument.
DOI: 10.5286/isis.e.rb2420036-1
title: Catalytic dehydration of model molecule of bio-oil to produce hydroxymethylfurfural: a potential carbon-neutral intermediate for the synthesis of biofuels and chemicals

description: Hydroxymethylfurfural (HMF) an intermediate used in the production of a broad spectrum of biofuels and chemicals, such as polyester containing furanic compounds, polyamides, polyurethanes, pharmaceuticals and organic derivatives. In this context, the dehydration of frutose and glucose using acid catalysts can be an environmentally friendly synthesis route of HMF. In this proposal, we intend to contribute to increasing knowledge about the mechanism of the catalytic dehydration reaction of glucose in Beta zeolite-based catalysts. More specifically, we will try to differentiate the roles of Brønsted and Lewis acid sites during the reaction, which will be done through Inelastic Neutron Scattering (INS) experiments on the TOSCA instrument.
DOI: 10.5286/isis.e.rb2510007-1
title: Fracton correlations in the square-lattice spiral spin-liquid candidate Sr2FeO4

description: Fractons are novel excitations with highly exotic transport properties, yet their experimental observation in real spin systems is still missing. Here we propose an inelastic neutron scattering experiment on MAPS to study the spin dynamics in a square-lattice compound Sr2FeO4, where fracton excitations may appear as the low-energy excitations of the spiral spin liquid state. Our proposed experiments may provide evidence for the first spiral spin liquid host on a square lattice and verify the theoretically proposed fracton physics.
DOI: 10.3535/lkk-y9f-jk2
title: Brassica rapa L.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.5286/isis.e.rb2510007
title: Fracton correlations in the square-lattice spiral spin-liquid candidate Sr2FeO4

description: Fractons are novel excitations with highly exotic transport properties, yet their experimental observation in real spin systems is still missing. Here we propose an inelastic neutron scattering experiment on MAPS to study the spin dynamics in a square-lattice compound Sr2FeO4, where fracton excitations may appear as the low-energy excitations of the spiral spin liquid state. Our proposed experiments may provide evidence for the first spiral spin liquid host on a square lattice and verify the theoretically proposed fracton physics.
DOI: 10.5286/isis.e.rb2510371
title: The solution interaction of diatrizoic acid with water towards hydrate formation

description: The incorporation of water into crystalline materials leads to significant problems in pharmaceutical formulation, as these materials show thermodynamically the lowest solubility in water leading to reduced bioavailability and potential inefficiency of the medicine. We are working on determining the interactions between solute and water in the pre-crystallisation solution with the aim to predict hydrate formation before the crystallisation experiment. We have recently worked on diatrizoic acid, an X-ray contrast agent that forms a highly stable dihydrate, and collected neutron total scattering data on the compound in DMSO solution with six equivalents of water. While the found interactions are not strong enough to warrant hydrate formation, we also discovered that the dihydrate does not crystallise from these solutions - they yield previously unknown crystal forms. We now propose to determine the solution structure of diatrizoic acid in DMSO:water 1:1 mixtures, from which the dihydrate does crystallise. With this data, we can determine the interaction characteristics needed for hydrate formation to occur, and why this material does not result from lower water contents.
DOI: 10.5286/isis.e.rb2510371-1
title: The solution interaction of diatrizoic acid with water towards hydrate formation

description: The incorporation of water into crystalline materials leads to significant problems in pharmaceutical formulation, as these materials show thermodynamically the lowest solubility in water leading to reduced bioavailability and potential inefficiency of the medicine. We are working on determining the interactions between solute and water in the pre-crystallisation solution with the aim to predict hydrate formation before the crystallisation experiment. We have recently worked on diatrizoic acid, an X-ray contrast agent that forms a highly stable dihydrate, and collected neutron total scattering data on the compound in DMSO solution with six equivalents of water. While the found interactions are not strong enough to warrant hydrate formation, we also discovered that the dihydrate does not crystallise from these solutions - they yield previously unknown crystal forms. We now propose to determine the solution structure of diatrizoic acid in DMSO:water 1:1 mixtures, from which the dihydrate does crystallise. With this data, we can determine the interaction characteristics needed for hydrate formation to occur, and why this material does not result from lower water contents.
DOI: 10.21233/n3w20s
title: Makar Inlet pollen surface sample dataset

description: Raw data for the Makar Inlet pollen surface sample dataset submitted to the Neotoma Paleoecology Database. Data is available through the landing page in JSON format. The landing page referenced by the DOI also contains links to publications and a map-based viewer for the dataset. The Neotoma Paleoecology Database maintains a homepage at https://www.neotomadb.org.
DOI: 10.34816/ifao.archives.232963
title: SAQQARA_nb_1994_06029

description: Référence : nb_1994_06029<br />Site : Saqqara<br />Secteur : Mastaba de Ti<br />Type : photographie<br />
DOI: 10.3535/nzb-7b3-dg2
title: Bryonia dioica Jacq.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/teb-psd-1sz
title: Chelidonium majus L.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.5286/isis.e.rb2510229-1
title: The structure of liquid pyrrole and solutions of benzene in pyrrole and methylamine: N-H··pi interactions in the liquid state

description: The aim of this proposal is to determine the structure of pure liquid pyrrole and solutions of benzene in liquid methylamine and pyrrole. From this study, we expect gain new understanding of N-H···pi and N(-H)···H-C weak hydrogen bonds, with wide practical and fundamental implications across the chemical, physical and biological sciences. This work will exploit thorough H/D isotope substitution and the wide Q-range of NIMROD. The latter is important to establish the extent of any local molecular clustering. We will use empirical potential structure refinement (EPSR) to analyse our data, complemented by classical Monte Carlo simulations.
DOI: 10.5286/isis.e.rb2510495
title: Enzyme Immobilization via Complex Coacervation with Polyampholytes

description: Complex coacervation is a liquid-liquid phase separation that is driven by non-covalent interactions and entropy gain as a result of counterion release. Coacervation is considered as the basis of membraneless organelles, and is used in various industrial applications. Our goal is to use coacervation for enzyme immobilization to maintain or enhance enzyme activity. Considering that biologically-origined macromolecules will have a higher range of application areas in medicine, we have chosen to work on coacervation of hyaluronic-acid derived polyampholytes with lysozyme. SANS measurements coupled with contrast matching will allow us to understand the structure of their coacervates, including the respective distribution of the enzymes and polyampholytes in the coacervate.
DOI: 10.5286/isis.e.rb2510495-1
title: Enzyme Immobilization via Complex Coacervation with Polyampholytes

description: Complex coacervation is a liquid-liquid phase separation that is driven by non-covalent interactions and entropy gain as a result of counterion release. Coacervation is considered as the basis of membraneless organelles, and is used in various industrial applications. Our goal is to use coacervation for enzyme immobilization to maintain or enhance enzyme activity. Considering that biologically-origined macromolecules will have a higher range of application areas in medicine, we have chosen to work on coacervation of hyaluronic-acid derived polyampholytes with lysozyme. SANS measurements coupled with contrast matching will allow us to understand the structure of their coacervates, including the respective distribution of the enzymes and polyampholytes in the coacervate.
DOI: 10.3535/ksp-znq-6el
title: Fumaria officinalis L.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/l5m-8cn-h4m
title: Plantae

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.5286/isis.e.rb2510185
title: Inelastic Neutron scattering study of Crystal Field Effect in CeAgAl3 and PrAgAl3

description: Kondo lattice systems CeCuAl3 and Ag-doped CeCu1-xAgxAl3 (x  0.3) present clear evidence for rare phenomenon of magnetoelastic coupling of crystal electric field (CEF) excitations and lattice vibrons. This motivated us to investigate the spin dynamics and CEF excitations in the end point compound CeAgAl3 which should help us understand the origin of magnetoelastic coupling in CeCu1-xAgxAl3 (0  x  0.3). CeAgAl3 forms in orthorhombic Cmcm structure which admits Ag/Al site-mixing. It has ferromagnetically ordered ground state below 3.8 K, but the short range magnetic correlations develop below 15 K. PrAgAl3 which also forms in orthorhombic Cmcm structure orders ferromagnetically below 5.5 K. We performed MERLIN express measurements on CeAgAl3 [RB2490017] and obtained interesting CEF excitations, but statistics is not enough for the publication. Further investigations of RAgAl3 (R=Ce and Pr) using the inelastic neutron scattering experiment are highly desired to determine the crystal field states of these compounds in order to understand the effect of single ion anisotropy. We propose to carry inelastic neutron scattering measurements on CeAgAl3 and PrAgAl3 using MARI spectrometer to determine the crystal field level scheme.
DOI: 10.5286/isis.e.rb2510185-1
title: Inelastic Neutron scattering study of Crystal Field Effect in CeAgAl3 and PrAgAl3

description: Kondo lattice systems CeCuAl3 and Ag-doped CeCu1-xAgxAl3 (x  0.3) present clear evidence for rare phenomenon of magnetoelastic coupling of crystal electric field (CEF) excitations and lattice vibrons. This motivated us to investigate the spin dynamics and CEF excitations in the end point compound CeAgAl3 which should help us understand the origin of magnetoelastic coupling in CeCu1-xAgxAl3 (0  x  0.3). CeAgAl3 forms in orthorhombic Cmcm structure which admits Ag/Al site-mixing. It has ferromagnetically ordered ground state below 3.8 K, but the short range magnetic correlations develop below 15 K. PrAgAl3 which also forms in orthorhombic Cmcm structure orders ferromagnetically below 5.5 K. We performed MERLIN express measurements on CeAgAl3 [RB2490017] and obtained interesting CEF excitations, but statistics is not enough for the publication. Further investigations of RAgAl3 (R=Ce and Pr) using the inelastic neutron scattering experiment are highly desired to determine the crystal field states of these compounds in order to understand the effect of single ion anisotropy. We propose to carry inelastic neutron scattering measurements on CeAgAl3 and PrAgAl3 using MARI spectrometer to determine the crystal field level scheme.
DOI: 10.5286/isis.e.rb2510229
title: The structure of liquid pyrrole and solutions of benzene in pyrrole and methylamine: N-H··pi interactions in the liquid state

description: The aim of this proposal is to determine the structure of pure liquid pyrrole and solutions of benzene in liquid methylamine and pyrrole. From this study, we expect gain new understanding of N-H···pi and N(-H)···H-C weak hydrogen bonds, with wide practical and fundamental implications across the chemical, physical and biological sciences. This work will exploit thorough H/D isotope substitution and the wide Q-range of NIMROD. The latter is important to establish the extent of any local molecular clustering. We will use empirical potential structure refinement (EPSR) to analyse our data, complemented by classical Monte Carlo simulations.
DOI: 10.34816/ifao.archives.232964
title: SAQQARA_nb_1994_06030

description: Référence : nb_1994_06030<br />Site : Saqqara<br />Secteur : Mastaba de Ti<br />Type : photographie<br />
DOI: 10.3535/mr0-v40-afw
title: Plantae

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/t4z-q7b-vhh
title: Hypericum perforatum L.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.5286/isis.e.rb2510289
title: Crystal field excitations of heavy fermion antiferromagnetic superconductor using inelastic neutron scattering

description: Rare earth intermetallic compounds exhibit fascinating phenomena, such as heavy fermion behaviour and superconductivity, owing to the interplay of interactions like RKKY exchange, spin-orbit coupling, and the crystal electric field (CEF). Specifically, Ce2RhIn8 displays pressure-induced superconductivity and acts as a three-dimensional counterpart to the well-studied CeRhIn5. The CEF splitting of Ce energy levels is a pivotal parameter for tuning the electronic properties of these materials, and previous studies indicate that Ce2RhIn8 has two low-lying CEF states that significantly influence its ground-state physics. However, the proposed CEF schemes from these studies are inconsistent as they were derived indirectly from the data. We propose a direct measurement of the CEF scheme in Ce2RhIn8 using inelastic neutron scattering, which will allow us to examine transitions between the CEF states and obtain precise values for energy levels, wave functions, and transition strengths. To this end, we will utilize the MERLIN instrument, which offers high flux at Ei = 50 meV and can operate in repetition-rate multiplication mode. This enables simultaneous data collection at Ei = 50 meV, 21.76 meV, and 12.12 meV (using a Gd chopper at 300 Hz), covering the relevant energy region. Data collected at 5 K and 180 K will be analyzed simultaneously to extract the necessary CEF parameters.
DOI: 10.5286/isis.e.rb2510289-1
title: Crystal field excitations of heavy fermion antiferromagnetic superconductor using inelastic neutron scattering

description: Rare earth intermetallic compounds exhibit fascinating phenomena, such as heavy fermion behaviour and superconductivity, owing to the interplay of interactions like RKKY exchange, spin-orbit coupling, and the crystal electric field (CEF). Specifically, Ce2RhIn8 displays pressure-induced superconductivity and acts as a three-dimensional counterpart to the well-studied CeRhIn5. The CEF splitting of Ce energy levels is a pivotal parameter for tuning the electronic properties of these materials, and previous studies indicate that Ce2RhIn8 has two low-lying CEF states that significantly influence its ground-state physics. However, the proposed CEF schemes from these studies are inconsistent as they were derived indirectly from the data. We propose a direct measurement of the CEF scheme in Ce2RhIn8 using inelastic neutron scattering, which will allow us to examine transitions between the CEF states and obtain precise values for energy levels, wave functions, and transition strengths. To this end, we will utilize the MERLIN instrument, which offers high flux at Ei = 50 meV and can operate in repetition-rate multiplication mode. This enables simultaneous data collection at Ei = 50 meV, 21.76 meV, and 12.12 meV (using a Gd chopper at 300 Hz), covering the relevant energy region. Data collected at 5 K and 180 K will be analyzed simultaneously to extract the necessary CEF parameters.
DOI: 10.5286/isis.e.rb2590010-1
title: PNR of BFPT/FM Heterostructures
DOI: 10.3535/77k-yvs-mm4
title: Plantae

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.