cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.22785483.v1
title: Levetiracetam plus Oxcarbazepine Combination Treatment Downregulates Serum Multidrug Resistance Protein 1 Levels and Upregulates Neuropeptide Y Levels in Children with Epilepsy

description: Abstract The aim of the present study was to investigate the usefulness of multidrug resistance protein 1 (MDR1) and neuropeptide Y (NPY) levels in predicting the efficacy of levetiracetam (LEV) plus oxcarbazepine (OXC) treatment administered to children with epilepsy and to determine their prognosis. Overall, 193 children with epilepsy admitted to the hospital were enrolled and randomly divided into two groups according to different treatment methods: group A (n = 106, treated with LEV plus OXC combination) and group B (n = 87, treated with OXC only). After treatment, compared with group B, group A exhibited a remarkably higher total effective rate and a significantly lower total adverse reaction rate. Areas under the curve for MDR1 and NPY for predicting ineffective treatment were 0.867 and 0.834, whereas those for predicting epilepsy recurrence were 0.916 and 0.829, respectively. Electroencephalography abnormalities, intracranial hemorrhage, neonatal convulsion, premature delivery, and MDR1 and NPY levels were independent risk factors for poor prognosis in children with epilepsy. Serum MDR1 and NPY levels exhibited a high predictive value for early epilepsy diagnosis, treatment efficacy assessment, and prognostication in children with epilepsy treated with LEV plus OXC combination.
DOI: 10.6084/m9.figshare.22785484
title: Brief Lower Body Functional Performance Questionnaire (Brief-LBFPQ) for independent older adults

description: Abstract Introduction The literature still lacks evidence about patient-reported outcome measures to fast screen the reduced physical performance of the lower body in older adults to be applied in any clinical setting as primary health care or without specific instruments in prevention campaigns, or even easy to be applied by phone. Objective: To develop a brief questionnaire to screen the lower body functional performance in community-dwelling older adults and to validate this new questionnaire with objective clinical tests. Methods A convenience sampling of 221 community-dwelling older adults was included in this cross-sectional study. The validity between Brief-LBFPQ and objective tests such as gait speed, Timed-Up and Go test (TUG), 5-Time Stand-to-Sit test (5TSST), and step test were assessed by multinominal logistic regression. Internal consistency was determined using Cronbach’s alpha and Test-retest reliability was determined using intraclass correlation coefficient (ICC) for numeral scale and Cohen’s Kappa for ordinal scale. Results Brief-LBFPQ was significantly associated with objective tests. All eight items from Brief-LBFPQ presented an absolute agreement with ICCs values above 0.7. Kappa values of Brief-LBFPQ items ranged from 0.6 to 0.83, showing substantial agreement and perfect agreement. Conclusion Brief-LBFPQ could be very useful in general clinic settings as it provides earlier screening of functional impairment in independent older adults, and consequently may allow an earlier intervention approach.
DOI: 10.6084/m9.figshare.22785484.v1
title: Brief Lower Body Functional Performance Questionnaire (Brief-LBFPQ) for independent older adults

description: Abstract Introduction The literature still lacks evidence about patient-reported outcome measures to fast screen the reduced physical performance of the lower body in older adults to be applied in any clinical setting as primary health care or without specific instruments in prevention campaigns, or even easy to be applied by phone. Objective: To develop a brief questionnaire to screen the lower body functional performance in community-dwelling older adults and to validate this new questionnaire with objective clinical tests. Methods A convenience sampling of 221 community-dwelling older adults was included in this cross-sectional study. The validity between Brief-LBFPQ and objective tests such as gait speed, Timed-Up and Go test (TUG), 5-Time Stand-to-Sit test (5TSST), and step test were assessed by multinominal logistic regression. Internal consistency was determined using Cronbach’s alpha and Test-retest reliability was determined using intraclass correlation coefficient (ICC) for numeral scale and Cohen’s Kappa for ordinal scale. Results Brief-LBFPQ was significantly associated with objective tests. All eight items from Brief-LBFPQ presented an absolute agreement with ICCs values above 0.7. Kappa values of Brief-LBFPQ items ranged from 0.6 to 0.83, showing substantial agreement and perfect agreement. Conclusion Brief-LBFPQ could be very useful in general clinic settings as it provides earlier screening of functional impairment in independent older adults, and consequently may allow an earlier intervention approach.
DOI: 10.6084/m9.figshare.22785487
title: Biological screening of herbal extracts and essential oil from Plectranthus species: α-amylase and 5-lipoxygenase inhibition and antioxidant and anti-Candida potentials

description: Abstract The phenolic compound content, the antioxidant and α-amylase inhibition potentials of different extracts of the Plectranthus amboinicus, P. barbatus and P. ornatus were evaluated. We also evaluated the influence of plant growth and harvest time on the chemical composition of the essential oil (EO) of P. amboinicus, its antioxidant and anti-Candida activities and the α-amylase and lipoxygenase inhibitions. The turbo-extract of P. barbatus showed the greatest phenolic compound content and antioxidant activity. No α-amylase inhibition activity was observed in the analyzed extracts, but the turbo-extraction and refluxing extracts possessed high antioxidant activities. Protected cultivation and morning harvest conditions gave the best antioxidant activities, which was associated to the highest carvacrol content. P. amboinicus EO antioxidant activity could contribute to the reduction of oxidative stress in diabetes. Causal Candida strains of diabetic foot ulcers showed sensitivity to P. amboinicus EO. C. albicans and C. dubliniensis were the most sensitive of the selected Candida strains. Turbo-extracts or refluxing of the three species extracts and the EO of P. amboinicus should be considered as a potential candidate for the management the complications of type 2 diabetes.
DOI: 10.6084/m9.figshare.22785487.v1
title: Biological screening of herbal extracts and essential oil from Plectranthus species: α-amylase and 5-lipoxygenase inhibition and antioxidant and anti-Candida potentials

description: Abstract The phenolic compound content, the antioxidant and α-amylase inhibition potentials of different extracts of the Plectranthus amboinicus, P. barbatus and P. ornatus were evaluated. We also evaluated the influence of plant growth and harvest time on the chemical composition of the essential oil (EO) of P. amboinicus, its antioxidant and anti-Candida activities and the α-amylase and lipoxygenase inhibitions. The turbo-extract of P. barbatus showed the greatest phenolic compound content and antioxidant activity. No α-amylase inhibition activity was observed in the analyzed extracts, but the turbo-extraction and refluxing extracts possessed high antioxidant activities. Protected cultivation and morning harvest conditions gave the best antioxidant activities, which was associated to the highest carvacrol content. P. amboinicus EO antioxidant activity could contribute to the reduction of oxidative stress in diabetes. Causal Candida strains of diabetic foot ulcers showed sensitivity to P. amboinicus EO. C. albicans and C. dubliniensis were the most sensitive of the selected Candida strains. Turbo-extracts or refluxing of the three species extracts and the EO of P. amboinicus should be considered as a potential candidate for the management the complications of type 2 diabetes.
DOI: 10.6084/m9.figshare.22785490
title: High microbiome variability in pediatric tracheostomy cannulas in patients with similar clinical characteristics

description: Abstract Objectives: To evaluate the bacterial microbiome found in tracheostomy cannulas of a group of children diagnosed with glossoptosis secondary to Robin Sequence (RS), and its clinical implications. Methods: Pediatric patients were enrolled in the study at the time of the cannula change in the hospital. During this procedure, the removed cannula was collected and stored for amplicon sequencing of 16s rRNA. DNA extraction was performed using DNeasy PowerBiofilm Kit (QIAGEN® - Cat nº 24000-50) while sequencing was performed with the S5 (Ion S5™ System, Thermo Fisher Scientific), following Brazilian Microbiome Project (BMP) protocol. Results: All 12 patients included in the study were using tracheostomy uncuffed cannulas of the same brand, had tracheostomy performed for over 1-year and had used the removed cannula for approximately 3-months. Most abundant genera found were Aggregatibacter, Pseudomonas, Haemophilus, Neisseria, Staphylococcus, Fusobacterium, Moraxella, Streptococcus, Alloiococcus, and Capnocytophaga. Individual microbiome of each individual was highly variable, not correlating to any particular clinical characteristic. Conclusion: The microbiome of tracheostomy cannulas is highly variable, even among patients with similar clinical characteristics, making it challenging to determine a standard for normality. © 2022 Associa¸c˜ao Brasileira de Otorrinolaringologia e Cirurgia C´ervico-Facial. Published by Elsevier Editora Ltda. This is an open access article under the CC BY license (https://creativecommons.org/licenses/by/4.0/).
DOI: 10.6084/m9.figshare.22785490.v1
title: High microbiome variability in pediatric tracheostomy cannulas in patients with similar clinical characteristics

description: Abstract Objectives: To evaluate the bacterial microbiome found in tracheostomy cannulas of a group of children diagnosed with glossoptosis secondary to Robin Sequence (RS), and its clinical implications. Methods: Pediatric patients were enrolled in the study at the time of the cannula change in the hospital. During this procedure, the removed cannula was collected and stored for amplicon sequencing of 16s rRNA. DNA extraction was performed using DNeasy PowerBiofilm Kit (QIAGEN® - Cat nº 24000-50) while sequencing was performed with the S5 (Ion S5™ System, Thermo Fisher Scientific), following Brazilian Microbiome Project (BMP) protocol. Results: All 12 patients included in the study were using tracheostomy uncuffed cannulas of the same brand, had tracheostomy performed for over 1-year and had used the removed cannula for approximately 3-months. Most abundant genera found were Aggregatibacter, Pseudomonas, Haemophilus, Neisseria, Staphylococcus, Fusobacterium, Moraxella, Streptococcus, Alloiococcus, and Capnocytophaga. Individual microbiome of each individual was highly variable, not correlating to any particular clinical characteristic. Conclusion: The microbiome of tracheostomy cannulas is highly variable, even among patients with similar clinical characteristics, making it challenging to determine a standard for normality. © 2022 Associa¸c˜ao Brasileira de Otorrinolaringologia e Cirurgia C´ervico-Facial. Published by Elsevier Editora Ltda. This is an open access article under the CC BY license (https://creativecommons.org/licenses/by/4.0/).
DOI: 10.6084/m9.figshare.22785489
title: The political risk of the Ukrainian war for the global fuel market: the case of British Petroleum in Russia

description: Abstract In February 2022, Russia invaded the eastern territories of Ukraine. Three days after the invasion, pressured by public opinion and the British government, British Petroleum (BP) announced the abandonment of its almost 20% equity shareholding in Russian state-owned Rosneft at an estimated cost of USD 25 billion for the company. The case puts the reader in the position of CEO Bernard Looney to reflect on the redesign of the company’s strategy with regard to assessing the impact of political risk on its other businesses in the world. The case was designed for undergraduate and graduate students in Business Administration, International Relations, and related areas who want to address topics such as oil geopolitics, business strategy, political risk, and international business.
DOI: 10.6084/m9.figshare.22785489.v1
title: The political risk of the Ukrainian war for the global fuel market: the case of British Petroleum in Russia

description: Abstract In February 2022, Russia invaded the eastern territories of Ukraine. Three days after the invasion, pressured by public opinion and the British government, British Petroleum (BP) announced the abandonment of its almost 20% equity shareholding in Russian state-owned Rosneft at an estimated cost of USD 25 billion for the company. The case puts the reader in the position of CEO Bernard Looney to reflect on the redesign of the company’s strategy with regard to assessing the impact of political risk on its other businesses in the world. The case was designed for undergraduate and graduate students in Business Administration, International Relations, and related areas who want to address topics such as oil geopolitics, business strategy, political risk, and international business.
DOI: 10.17632/m6syy2ndsn.1
title: PSSS Patellofemoral Pain Severity Scale in Patients with Patellofemoral Pain Syndrome

description: Patellofemoral Pain Severity Scale in Patients with Patellofemoral Pain Syndrome
Reliability and Validity of the Turkish version of the Patellofemoral Pain Severity Scale in Patients with Patellofemoral Pain Syndrome
Abstract
Purpose: It was planned to investigate the Turkish validity and reliability of the Patellofemoral Pain Severity Scale (PFPS) and to ensure its adaptation to the Turkish language.
Materials and methods: A pilot study was conducted with 10 academic physiotherapists and 10 patients to test content validity. 123 patients underwent PPPS test-retest at 24-48 hour intervals.  Construct validity, correlations of PPPS with other scales Timed Up and Go Test (TUG), Stair Climbing and Descending Test (SCD), Anterior Knee Pain Scale (AKPS), Tegner Activity Scale (TAS), Lysholm Knee Scoring Scale (LDSS), Knee Outcome Survey Activities of Daily Living Scale (KOS-ADL) were evaluated.
Results: The content validity index value of the scale was 0.95. The overall internal consistency (Cronbach α: 0.88) was high. Item-total correlations of the scale were between 0.51 (PSSS 9) and 0.71 (PSSS 4). In the evaluation of the convergent validity of the PSSS, it was found that there was a positive correlation between the PSSS and TUG and SCD, and a negative correlation between the PSSS, TAS, LDSS and KOS-ADL (p=0.000).
Conclusions: In this study, it was determined that the PSSS scale had good internal consistency, test-retest validity and adequate construct validity when compared with the KOS-ADL, LDSS and ACPS. These findings suggest that the scale is a reliable and valid measurement tool for native Turkish-speaking patients with PFPS.
Key words: Patellofemoral pain syndrome, pain, function; outcome measures; reliability; validity
DOI: 10.5281/zenodo.7641280
title: Supporting information for the RNAct Data Science Wizard (DSW) knowledge model for early-stage researchers.

description: The two attached Excel sheets contain information about the datasets collected by the Early Stage Researchers (ESRs) in the RNAct MSCA-ITN project (RNAct_datasets.xlsx) and on the questionnaire that was put to the ESRs in relation to the Data Science Wizard (DSW) knowledge model that was developed as part of RNAct.
DOI: 10.5281/zenodo.7641279
title: Supporting information for the RNAct Data Science Wizard (DSW) knowledge model for early-stage researchers.

description: The two attached Excel sheets contain information about the datasets collected by the Early Stage Researchers (ESRs) in the RNAct MSCA-ITN project (RNAct_datasets.xlsx) and on the questionnaire that was put to the ESRs in relation to the Data Science Wizard (DSW) knowledge model that was developed as part of RNAct. The zip file contains data in relation to the Data Science Wizard template development: - DMP_1stRound_introductory_presentation.pdf: Presentation for the ESRs to prepare them for filling in the first version of the DMP - DMPs_1stRound, DMPs_2ndRound: The filled in DMPs by the ESRs in the first and second round - RNAct-ESRtraining-KM_1.0.3.km: The first version of the knowledge model to create the DMP - RNAct-ESRtraining-KM_1.0.14.km: The second and final version of the knowledge model to create the DMP - TemplateDMP_RNAct-ESRtraining-KM_1.0.14.pdf: A PDF overview of the second and final version of the knowledge model
DOI: 10.5281/zenodo.7912419
title: Supporting information for the RNAct Data Science Wizard (DSW) knowledge model for early-stage researchers.

description: The two attached Excel sheets contain information about the datasets collected by the Early Stage Researchers (ESRs) in the RNAct MSCA-ITN project (RNAct_datasets.xlsx) and on the questionnaire that was put to the ESRs in relation to the Data Science Wizard (DSW) knowledge model that was developed as part of RNAct. The zip file contains data in relation to the Data Science Wizard template development: - DMP_1stRound_introductory_presentation.pdf: Presentation for the ESRs to prepare them for filling in the first version of the DMP - DMPs_1stRound, DMPs_2ndRound: The filled in DMPs by the ESRs in the first and second round - RNAct-ESRtraining-KM_1.0.3.km: The first version of the knowledge model to create the DMP - RNAct-ESRtraining-KM_1.0.14.km: The second and final version of the knowledge model to create the DMP - TemplateDMP_RNAct-ESRtraining-KM_1.0.14.pdf: A PDF overview of the second and final version of the knowledge model
DOI: 10.6084/m9.figshare.22785492
title: Effectiveness of the self-regulation educational program in increasing knowledge about COVID-19 in Peruvian soldiers

description: ABSTRACT Objective: To determine the effectiveness of the educational program based on self-regulation of learning in the level of knowledge about COVID-19 in the soldiers. Methods: Pre-experimental study with a pre-test and post-test design with a single group, carried out in 2020. 179 soldiers from Puno, Peru participated. Two expository-participatory sessions and a demonstrative workshop were developed. A valid (Aiken’s V = 0.69) and reliable (McDonald’s Omega = 0.81) questionnaire was used. The Friedman’s test was used to compare the results pre and post-test. Results: The level of knowledge about COVID-19 and in two of its dimensions changed from poor (pre-test) to regular (post-test). However, in the preventive measures dimension, it changed from poor (pre-test) to excellent (post-test). Conclusion: The proposed educational intervention was effective in increasing knowledge about COVID-19 in the soldiers, mainly in terms of preventive measures.
DOI: 10.6084/m9.figshare.22785492.v1
title: Effectiveness of the self-regulation educational program in increasing knowledge about COVID-19 in Peruvian soldiers

description: ABSTRACT Objective: To determine the effectiveness of the educational program based on self-regulation of learning in the level of knowledge about COVID-19 in the soldiers. Methods: Pre-experimental study with a pre-test and post-test design with a single group, carried out in 2020. 179 soldiers from Puno, Peru participated. Two expository-participatory sessions and a demonstrative workshop were developed. A valid (Aiken’s V = 0.69) and reliable (McDonald’s Omega = 0.81) questionnaire was used. The Friedman’s test was used to compare the results pre and post-test. Results: The level of knowledge about COVID-19 and in two of its dimensions changed from poor (pre-test) to regular (post-test). However, in the preventive measures dimension, it changed from poor (pre-test) to excellent (post-test). Conclusion: The proposed educational intervention was effective in increasing knowledge about COVID-19 in the soldiers, mainly in terms of preventive measures.
DOI: 10.6084/m9.figshare.22785493
title: Optimization of the ellagic acid synthesis process at the bioreactor level using non-conventional yeasts

description: Abstract Ellagic acid (EA) is a phenolic biomolecule. For its biosynthesis, a source of ellagitannins is required, such as strawberries and yeasts, as precursors of the tannase and β-glucosidase enzymes responsible for hydrolysis of ellagitannins. Two experimental mixture designs were applied., varying the yeast concentration and the number of ellagitannins in the culture medium, evaluating the enzymatic activity and ellagic acid biosynthesis. Aiming to find the optimal compositions of the non-conventional yeasts assessed in the research to biosynthesize ellagic acid feasibly and efficiently using a response surface performing the statistical analysis in the StatGraphics® program for obtaining a higher yield and optimizing the ellagic acid synthesis process, the results indicate that the strains Candida parapsilosis ITM LB33 and Debaryomyces hansenii ISA 1510 have a positive effect on the synthesis of ellagic acid, since as its concentration increases in the mixture the concentration of ellagic acid in the medium also increases; on the other hand, the addition of Candida utilis ITM LB02 causes a negative effect, resulting in the compositions of 0.516876, 0.483124 and 2.58687E-9 respectively, for a treatment under the same conditions, an optimal value of ellagic acid production would be obtained. With an approximate value of 7.33036 mg/mL.
DOI: 10.6084/m9.figshare.22785493.v1
title: Optimization of the ellagic acid synthesis process at the bioreactor level using non-conventional yeasts

description: Abstract Ellagic acid (EA) is a phenolic biomolecule. For its biosynthesis, a source of ellagitannins is required, such as strawberries and yeasts, as precursors of the tannase and β-glucosidase enzymes responsible for hydrolysis of ellagitannins. Two experimental mixture designs were applied., varying the yeast concentration and the number of ellagitannins in the culture medium, evaluating the enzymatic activity and ellagic acid biosynthesis. Aiming to find the optimal compositions of the non-conventional yeasts assessed in the research to biosynthesize ellagic acid feasibly and efficiently using a response surface performing the statistical analysis in the StatGraphics® program for obtaining a higher yield and optimizing the ellagic acid synthesis process, the results indicate that the strains Candida parapsilosis ITM LB33 and Debaryomyces hansenii ISA 1510 have a positive effect on the synthesis of ellagic acid, since as its concentration increases in the mixture the concentration of ellagic acid in the medium also increases; on the other hand, the addition of Candida utilis ITM LB02 causes a negative effect, resulting in the compositions of 0.516876, 0.483124 and 2.58687E-9 respectively, for a treatment under the same conditions, an optimal value of ellagic acid production would be obtained. With an approximate value of 7.33036 mg/mL.