cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.20014253
title: Universal newborn hearing screening: knowledge of pediatricians and neonatologists in the city of Jundiaí, São Paulo, Brazil

description: INTRODUCTION: Hearing loss has severe emotional, psychological, and social consequences. The early identification of hearing impairment is crucial. OBJECTIVE: To evaluate and quantify the knowledge of neonatologists, pediatricians, and residents in pediatrics regarding detection, risk factors, early diagnosis, and referral for rehabilitation of patients with neonatal hearing loss in Jundiaí, state of São Paulo, Brazil. METHODS: This was a cross-sectional contemporary cohort study including 47 physicians from three hospitals, including a questionnaire with 15 items. RESULTS: Most respondents (83%) had received information about hearing loss in their medical courses, but most had no knowledge of techniques for hearing evaluation, and degrees and types of loss. All physicians agreed that in the first six months of life, it is possible to evaluate hearing function and that it is the physician's responsibility to assess the newborn. Regarding the age that the child can receive auditory rehabilitation, the end of the first year and the second year of life predominate. CONCLUSION: Most respondents know the risk factors for the detection of neonatal hearing impairment, know how to perform procedures, and recognize the importance of diagnosis of hearing loss and the need to refer suspected cases, but most do not know the techniques used to assess hearing in newborns.
DOI: 10.6084/m9.figshare.20014253.v1
title: Universal newborn hearing screening: knowledge of pediatricians and neonatologists in the city of Jundiaí, São Paulo, Brazil

description: INTRODUCTION: Hearing loss has severe emotional, psychological, and social consequences. The early identification of hearing impairment is crucial. OBJECTIVE: To evaluate and quantify the knowledge of neonatologists, pediatricians, and residents in pediatrics regarding detection, risk factors, early diagnosis, and referral for rehabilitation of patients with neonatal hearing loss in Jundiaí, state of São Paulo, Brazil. METHODS: This was a cross-sectional contemporary cohort study including 47 physicians from three hospitals, including a questionnaire with 15 items. RESULTS: Most respondents (83%) had received information about hearing loss in their medical courses, but most had no knowledge of techniques for hearing evaluation, and degrees and types of loss. All physicians agreed that in the first six months of life, it is possible to evaluate hearing function and that it is the physician's responsibility to assess the newborn. Regarding the age that the child can receive auditory rehabilitation, the end of the first year and the second year of life predominate. CONCLUSION: Most respondents know the risk factors for the detection of neonatal hearing impairment, know how to perform procedures, and recognize the importance of diagnosis of hearing loss and the need to refer suspected cases, but most do not know the techniques used to assess hearing in newborns.
DOI: 10.6084/m9.figshare.19772119
title: Photosensitivity, circadian rhythm and sophisticated neurons revealed by a deep-sea Venus flytrap sea anemone genome

description: The Venus flytrap sea anemones <em>Actinoscyphia</em> live in the deep-sea environment. Different from other sea anemones, <em>Actinoscyphia</em> show specialized morphology with complete bisymmetry. Moreover, their pedal discs possess unusual abilities to stand upright and flexibly seizuring other objects. To understand the ecological success of this special species, we sequenced the genome of a deep-sea anemone <em>Actinoscyphia</em> sp. collected from 1,403 m on the Kocebu Guyot and focused on their photosensitivity, circadian rhythm and nervous system.
DOI: 10.6084/m9.figshare.19772119.v3
title: Photosensitivity, circadian rhythm and sophisticated neurons revealed by a deep-sea Venus flytrap sea anemone genome

description: The Venus flytrap sea anemones <em>Actinoscyphia</em> live in the deep-sea environment. Different from other sea anemones, <em>Actinoscyphia</em> show specialized morphology with complete bisymmetry. Moreover, their pedal discs possess unusual abilities to stand upright and flexibly seizuring other objects. To understand the ecological success of this special species, we sequenced the genome of a deep-sea anemone <em>Actinoscyphia</em> sp. collected from 1,403 m on the Kocebu Guyot and focused on their photosensitivity, circadian rhythm and nervous system.
DOI: 10.6084/m9.figshare.19772119.v2
title: Signatures of photosensitivity, circadian rhythm and advanced neurons revealed by a deep-sea Venus flytrap sea anemone genome

description: The Venus flytrap sea anemones <em>Actinoscyphia</em> live in the deep-sea environment. Different from other sea anemones, <em>Actinoscyphia</em> show specialized morphology with complete bisymmetry. Moreover, their pedal discs possess unusual abilities to stand upright and flexibly seizuring other objects. To understand the ecological success of this special species, we sequenced the genome of a deep-sea anemone <em>Actinoscyphia</em> sp. collected from 1,403 m on the Kocebu Guyot and focused on their photosensitivity, circadian rhythm and nervous system.
DOI: 10.6084/m9.figshare.20014255
title: Lack of protection against gentamicin ototoxicity by auditory conditioning with noise

description: INTRODUCTION: Auditory conditioning consists of the pre-exposure to low levels of a potential harmful agent to protect against a subsequent harmful presentation. OBJECTIVE: To confirm if conditioning with an agent different from the used to cause the trauma can also be effective. METHOD: Experimental study with 17 guinea pigs divided as follows: group Som: exposed to 85 dB broadband noise centered at 4 kHz, 30 minutes a day for 10 consecutive days; group Cont: intramuscular administration of gentamicin 160 mg/kg a day for 10 consecutive days; group Expt: conditioned with noise similarly to group Som and, after each noise presentation, received gentamicin similarly to group Cont. The animals were evaluated by distortion product otoacoustic emissions (DPOAEs), brainstem auditory evoked potentials (BAEPs) and scanning electron microscopy. RESULTS: The animals that were conditioned with noise did not show any protective effect compared to the ones that received only the ototoxic gentamicin administration. This lack of protection was observed functionally and morphologically. CONCLUSION: Conditioning with 85 dB broadband noise, 30 min a day for 10 consecutive days does not protect against an ototoxic gentamicin administration of 160 mg/kg a day for 10 consecutive days in the guinea pig.
DOI: 10.6084/m9.figshare.20014255.v1
title: Lack of protection against gentamicin ototoxicity by auditory conditioning with noise

description: INTRODUCTION: Auditory conditioning consists of the pre-exposure to low levels of a potential harmful agent to protect against a subsequent harmful presentation. OBJECTIVE: To confirm if conditioning with an agent different from the used to cause the trauma can also be effective. METHOD: Experimental study with 17 guinea pigs divided as follows: group Som: exposed to 85 dB broadband noise centered at 4 kHz, 30 minutes a day for 10 consecutive days; group Cont: intramuscular administration of gentamicin 160 mg/kg a day for 10 consecutive days; group Expt: conditioned with noise similarly to group Som and, after each noise presentation, received gentamicin similarly to group Cont. The animals were evaluated by distortion product otoacoustic emissions (DPOAEs), brainstem auditory evoked potentials (BAEPs) and scanning electron microscopy. RESULTS: The animals that were conditioned with noise did not show any protective effect compared to the ones that received only the ototoxic gentamicin administration. This lack of protection was observed functionally and morphologically. CONCLUSION: Conditioning with 85 dB broadband noise, 30 min a day for 10 consecutive days does not protect against an ototoxic gentamicin administration of 160 mg/kg a day for 10 consecutive days in the guinea pig.
DOI: 10.6084/m9.figshare.20014256.v1
title: Morphometric analysis of nasal shapes and angles in young adults

description: INTRODUCTION: The size, angle, shape, and type of nose is a signature indicating race, age, and sex. OBJECTIVE: Describe and compare nasal angles, nose types, nostril models, and nasal profiles in young Turkish males and females. METHODS: The study group consisted of university students, 56 males and 59 females. Nasal measurements were obtained from all subjects, using anthropometric methods. RESULTS: The nose types of females and males were 78% and 70% narrow nose, respectively. The means of females' nasofrontal, nasal tip, nasolabial, and alar slope angles were 133.16 ± 8.88; 77.91 ± 9.80 ; 98.91 ± 10.01 , and 80.89 ± 8.33 , respectively. The means of males' nasofrontal, nasal tip, nasolabial, and alar slope angles were 123.85 ± 13.23 ; 82.16 ± 9.98 ; 97.91 ± 8.78 and 85.98 ± 8.72 , respectively. CONCLUSION: The average values of the nose in this population may be used as a guide to plan corrective aesthetic-cosmetic surgery and for burn scars of the nose.
DOI: 10.6084/m9.figshare.20014256
title: Morphometric analysis of nasal shapes and angles in young adults

description: INTRODUCTION: The size, angle, shape, and type of nose is a signature indicating race, age, and sex. OBJECTIVE: Describe and compare nasal angles, nose types, nostril models, and nasal profiles in young Turkish males and females. METHODS: The study group consisted of university students, 56 males and 59 females. Nasal measurements were obtained from all subjects, using anthropometric methods. RESULTS: The nose types of females and males were 78% and 70% narrow nose, respectively. The means of females' nasofrontal, nasal tip, nasolabial, and alar slope angles were 133.16 ± 8.88; 77.91 ± 9.80 ; 98.91 ± 10.01 , and 80.89 ± 8.33 , respectively. The means of males' nasofrontal, nasal tip, nasolabial, and alar slope angles were 123.85 ± 13.23 ; 82.16 ± 9.98 ; 97.91 ± 8.78 and 85.98 ± 8.72 , respectively. CONCLUSION: The average values of the nose in this population may be used as a guide to plan corrective aesthetic-cosmetic surgery and for burn scars of the nose.
DOI: 10.6084/m9.figshare.20014262
title: Effects of the reduction of caffeine consumption on tinnitus perception

description: INTRODUCTION: For many years, excessive caffeine consumption has been touted as an aggravating factor for tinnitus. The pathophysiology behind this effect is probably related to the blockage of adenosine receptors by the action of caffeine on the central nervous system. OBJECTIVE: To evaluate the effects of reduction of coffee consumption on tinnitus sensation and to identify subgroups more prone to benefit from this therapeutic strategy. Study design: prospective. METHODS: Twenty-six tinnitus patients who consumed at least 150 mL of coffee per day were selected. All were asked to reduce their coffee consumption. The Tinnitus Handicap Inventory (THI) questionnaire was completed by the patients before and after the reduction of coffee consumption, as well as a visual-analogue scale (VAS) graduated from 1 to 10. RESULTS: THI and VAS scores were significantly reduced (p &lt; 0.05). In the subgroups less than 60 years old, bilateral tinnitus and daily coffee consumption between 150 and 300 mL showed a significantly greater reduction of THI and VAS scores. CONCLUSION: Patients under 60 years of age with bilateral tinnitus and daily coffee consumption between 150 and 300 mL are more prone to benefit from consumption reduction. Thirty-day observation periods may be helpful for a better therapeutical decision.
DOI: 10.6084/m9.figshare.20014262.v1
title: Effects of the reduction of caffeine consumption on tinnitus perception

description: INTRODUCTION: For many years, excessive caffeine consumption has been touted as an aggravating factor for tinnitus. The pathophysiology behind this effect is probably related to the blockage of adenosine receptors by the action of caffeine on the central nervous system. OBJECTIVE: To evaluate the effects of reduction of coffee consumption on tinnitus sensation and to identify subgroups more prone to benefit from this therapeutic strategy. Study design: prospective. METHODS: Twenty-six tinnitus patients who consumed at least 150 mL of coffee per day were selected. All were asked to reduce their coffee consumption. The Tinnitus Handicap Inventory (THI) questionnaire was completed by the patients before and after the reduction of coffee consumption, as well as a visual-analogue scale (VAS) graduated from 1 to 10. RESULTS: THI and VAS scores were significantly reduced (p &lt; 0.05). In the subgroups less than 60 years old, bilateral tinnitus and daily coffee consumption between 150 and 300 mL showed a significantly greater reduction of THI and VAS scores. CONCLUSION: Patients under 60 years of age with bilateral tinnitus and daily coffee consumption between 150 and 300 mL are more prone to benefit from consumption reduction. Thirty-day observation periods may be helpful for a better therapeutical decision.
DOI: 10.6084/m9.figshare.20014202
title: AffixStat - derivational

description: Data files for AffixStat project (derivational morphology influences suffixing preference) - Slovak and German populations
DOI: 10.6084/m9.figshare.20014202.v1
title: AffixStat - derivational

description: Data files for AffixStat project (derivational morphology influences suffixing preference) - Slovak and German populations
DOI: 10.6084/m9.figshare.20014264
title: Balloon laryngoplasty for acquired subglottic stenosis in children: predictive factors for success

description: INTRODUCTION: The treatment of subglottic stenosis in children remains a challenge for the otorhinolaryngologist, and may involve both endoscopic and open surgery. OBJECTIVE: To report the experience of two tertiary facilities in the treatment of acquired subglottic stenosis in children with balloon laryngoplasty, and to identify predictive factors for success of the technique and its complications. METHODS: Descriptive, prospective study of children diagnosed with acquired subglottic stenosis and submitted to balloon laryngoplasty as primary treatment. RESULTS: Balloon laryngoplasty was performed in 37 children with an average age of 22.5 months; 24 presented chronic subglottic stenosis and 13 acute subglottic stenosis. Success rates were 100% for acute subglottic stenosis and 32% for chronic subglottic stenosis. Success was significantly associated with acute stenosis, initial grade of stenosis, children of a smaller age, and the absence of tracheostomy. Transitory dysphagia was the only complication observed in three children. CONCLUSION: Balloon laryngoplasty may be considered the first line of treatment for acquired subglottic stenosis. In acute cases, the success rate is 100%, and although the results are less promising in chronic cases, complications are not significant and the possibility of open surgery remains without prejudice.
DOI: 10.6084/m9.figshare.20014264.v1
title: Balloon laryngoplasty for acquired subglottic stenosis in children: predictive factors for success

description: INTRODUCTION: The treatment of subglottic stenosis in children remains a challenge for the otorhinolaryngologist, and may involve both endoscopic and open surgery. OBJECTIVE: To report the experience of two tertiary facilities in the treatment of acquired subglottic stenosis in children with balloon laryngoplasty, and to identify predictive factors for success of the technique and its complications. METHODS: Descriptive, prospective study of children diagnosed with acquired subglottic stenosis and submitted to balloon laryngoplasty as primary treatment. RESULTS: Balloon laryngoplasty was performed in 37 children with an average age of 22.5 months; 24 presented chronic subglottic stenosis and 13 acute subglottic stenosis. Success rates were 100% for acute subglottic stenosis and 32% for chronic subglottic stenosis. Success was significantly associated with acute stenosis, initial grade of stenosis, children of a smaller age, and the absence of tracheostomy. Transitory dysphagia was the only complication observed in three children. CONCLUSION: Balloon laryngoplasty may be considered the first line of treatment for acquired subglottic stenosis. In acute cases, the success rate is 100%, and although the results are less promising in chronic cases, complications are not significant and the possibility of open surgery remains without prejudice.
DOI: 10.6084/m9.figshare.20014265.v1
title: Repeated fine-needle aspiration cytology for the diagnosis and follow-up of thyroid nodules

description: INTRODUCTION: The recently-proposed Bethesda reporting system has offered clinical recommendations for each category of reported thyroid cytology, including repeated fine-needle aspiration (FNA) for non-diagnostic and atypia/follicular lesions of undetermined significance, but there are no sound indications for repeated examination after an initial benign exam. OBJECTIVE: To investigate the clinical validity of repeated FNA in the management of patients with thyroid nodules. METHOD: The present study evaluated 412 consecutive patients who had repeated aspiration biopsies of thyroid nodules after an initial non-diagnostic, atypia/follicular lesion of undetermined significance, or benign cytology. RESULTS: The majority of patients were female (93.5%) ranging from 13 to 83 years. Non-diagnostic cytology was the most common indication for a repeated examination in 237 patients (57.5%), followed by benign (36.8%), and A/FLUS (5.6%) cytology. A repeated examination altered the initial diagnosis in 70.5% and 78.3% of the non-diagnostic and A/FLUS patients, respectively, whereas only 28.9% of patients with a benign cytology presented with a different diagnosis on a sequential FNA. CONCLUSIONS: Repeat FNA is a valuable procedure in cases with initial non-diagnostic or A/FLUS cytology, but its routine use for patients with an initial benign examination appears to not increase the expected likelihood of a malignant finding.
DOI: 10.6084/m9.figshare.20014265
title: Repeated fine-needle aspiration cytology for the diagnosis and follow-up of thyroid nodules

description: INTRODUCTION: The recently-proposed Bethesda reporting system has offered clinical recommendations for each category of reported thyroid cytology, including repeated fine-needle aspiration (FNA) for non-diagnostic and atypia/follicular lesions of undetermined significance, but there are no sound indications for repeated examination after an initial benign exam. OBJECTIVE: To investigate the clinical validity of repeated FNA in the management of patients with thyroid nodules. METHOD: The present study evaluated 412 consecutive patients who had repeated aspiration biopsies of thyroid nodules after an initial non-diagnostic, atypia/follicular lesion of undetermined significance, or benign cytology. RESULTS: The majority of patients were female (93.5%) ranging from 13 to 83 years. Non-diagnostic cytology was the most common indication for a repeated examination in 237 patients (57.5%), followed by benign (36.8%), and A/FLUS (5.6%) cytology. A repeated examination altered the initial diagnosis in 70.5% and 78.3% of the non-diagnostic and A/FLUS patients, respectively, whereas only 28.9% of patients with a benign cytology presented with a different diagnosis on a sequential FNA. CONCLUSIONS: Repeat FNA is a valuable procedure in cases with initial non-diagnostic or A/FLUS cytology, but its routine use for patients with an initial benign examination appears to not increase the expected likelihood of a malignant finding.
DOI: 10.6084/m9.figshare.20014268
title: Review of experimental models: sinusitis in rabbits

description: INTRODUCTION: In order to better understand the pathophysiology of rhinosinusitis, several attempts have been made to create the disease in an animal model. Among the studied rodents each has its advantages and disadvantages. Rabbits are considered more appropriate for studies that require surgical manipulation or invasive procedures. OBJECTIVES: To evaluate the most viable experimental model of rhinosinusitis in rabbits to be adopted in future studies. METHODS: An electronic search for studies with experimental models of rhinosinusitis in rabbits published in English and Portuguese between July of 1967 and January of 2013 was conducted in Medline, Pub Med, Cochrane, and CAPES databases, using the keywords "sinusitis", "rabbits", and "polyps". RESULTS: A total of 256 studies were retrieved, but in accordance with the inclusion and exclusion criteria, only ten studies were selected. Many different methods of response assessment were used in these studies. CONCLUSION: To date, there is no ideal experimental model for induction of acute or chronic rhinosinusitis in rabbits, but the rhinogenic model appears to be the most viable option for the continuity of studies of the disease.
DOI: 10.6084/m9.figshare.20014268.v1
title: Review of experimental models: sinusitis in rabbits

description: INTRODUCTION: In order to better understand the pathophysiology of rhinosinusitis, several attempts have been made to create the disease in an animal model. Among the studied rodents each has its advantages and disadvantages. Rabbits are considered more appropriate for studies that require surgical manipulation or invasive procedures. OBJECTIVES: To evaluate the most viable experimental model of rhinosinusitis in rabbits to be adopted in future studies. METHODS: An electronic search for studies with experimental models of rhinosinusitis in rabbits published in English and Portuguese between July of 1967 and January of 2013 was conducted in Medline, Pub Med, Cochrane, and CAPES databases, using the keywords "sinusitis", "rabbits", and "polyps". RESULTS: A total of 256 studies were retrieved, but in accordance with the inclusion and exclusion criteria, only ten studies were selected. Many different methods of response assessment were used in these studies. CONCLUSION: To date, there is no ideal experimental model for induction of acute or chronic rhinosinusitis in rabbits, but the rhinogenic model appears to be the most viable option for the continuity of studies of the disease.
DOI: 10.6084/m9.figshare.20014270
title: Impact of early elective tracheotomy in critically ill patients

description: INTRODUCTION: Tracheotomy is one of the most frequent surgical procedures performed in critically ill patients hospitalized at intensive care units. The ideal timing for a tracheotomy is still controversial, despite decades of experience. OBJECTIVE: To determine the impact of performing early tracheotomies in critically ill patients on duration of mechanical ventilation, intensive care unit stay, overall hospital stay, morbidity, and mortality. METHODS: Retrospective and observational study of cases subjected to elective tracheotomy at one of the intensive care units of this hospital during five consecutive years. The patients were stratified into two groups: early tracheotomy group (tracheotomy performed from day one up to and including day seven of mechanical ventilation) and late tracheotomy group (tracheotomy performed after day seven). The outcomes of the groups were compared. RESULTS: In the early tracheotomy group, there was a statistically significant reduction in duration of mechanical ventilation (6 days vs. 19 days; p &lt; 0.001), duration of intensive care unit stay (10 days vs. 28 days; p = 0.001), and incidence of ventilator-associated pneumonia (1 case vs. 44 cases; p = 0.001). CONCLUSION: Early tracheotomy has a significant positive impact on critically ill patients hospitalized at this intensive care unit. These results support the tendency to balance the risk-benefit analysis in favor of early tracheotomy.