DOI: 10.5061/dryad.crjdfn32f
title: Umbilical artery lactate levels and associated maternal and newborn characteristics at Mulago National Referral Hospital: A cross-sectional observational study

description: Objective: To determine the maternal and newborn characteristics
 associated with high umbilical artery lactate levels at Mulago National
 Referral Hospital. Design: Cross-sectional observational study. Setting:
 Department of Obstetrics and Gynecology at a national referral hospital
 located in the capital of Uganda, Kampala. Participants: We randomly
 selected 720 pregnant mothers at term who presented in labour and their
 newborn babies. Primary outcome: Umbilical artery lactate level. Results:
 During the study, there were 579 vaginal deliveries (18 instrumental) and
 141 caesarean sections which met the inclusion criteria. One hundred
 eighty seven neonates (187) had high arterial lactate levels. The
 following factors were associated with an increased likelihood of high
 lactate concentration: male sex (aOR = 1.71; 95%CI 1.16–2.54;
 P&lt;0.05), primigravidity (aOR = 2.78; 95%CI 1.89-4.08; P &lt;
 0.001), Meconium stained liquor (MSL) (aOR = 5.85; 95%CI 4.08-8.47;
 P&lt;0.001) and, Administration of oxytocin (aOR = 1.97; 95%CI
 1.00-3.77; P&lt;0.05). Conclusion: About a fifth of the babies born in
 Mulago national referral hospital during the study period had high
 umbilical artery lactate. The maternal-fetal factors significantly
 associated with high umbilical artery lactate levels included: baby’s sex,
 mother’s gravidity, meconium stained amniotic fluid, and oxytocin
 administration during labour.
description: The
 participants’ baseline characteristics such as age, gravidity, gestational
 age, and blood pressure were collected using a data form. Following
 vaginal or caesarean delivery, a 20 cm segment of umbilical cord was
 doubly clamped and one sample of 2 ml of arterial blood drawn from between
 the clamps within 5 minutes of delivery. The first
 study assistant immediately used 20-30 µL of sampled blood and measured
 its lactate concentration using a point-of-care lactate meter (Accutrend
 Plus system; Roche Diagnostics, Rotkreuz Switzerland). The precision range
 of the meter is 0.8-22 mmol/L at 15 – 35<sup>o</sup>C and the
 coefficient of variation is 1.8 to 3%. The newborn
 characteristic such as mode of delivery, sex, birth weight, and exposure
 to meconium stained amniotic fluid were also documented. We documented the
 Apgar score at 1 and 5 minutes, if the neonate was resuscitated after
 birth, admitted to the nursery, and if they died. It was also documented
 if the mother received any medication during the intrapartum period such
 as oxytocin, antibiotics, anti-convulsants (magnesium sulfate), and
 prostaglandins for labour induction.
description: - The dataset file has an extension
 <strong>'.epx'</strong> - The
 dataset was created using software EpiData Ver 4.4; <strong>EpiData
 Entry Client</strong> - This software can be
 downloaded using the following link: https://www.epidata.dk/php/downloadc.php?file=setup_epidata.exe Copy and paste the above link into your browser and open it. You will be prompted to '<strong>save</strong>' the executable setup file Open the file and install the EpiData Ver 4.4 complete suite. Use the EpiData Entry client to view the dataset - The <strong>EpiData Manager Ver 4.4</strong> can be use to open and export the dataset to other formats such as STATA for analysis