cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.30022648.v1
title: Feasibility and Prognostic Analysis of Neoadjuvant Therapy Followed by Breast-Conserving Surgery for Invasive Ductal Carcinoma Combined with Ductal Carcinoma in Situ

description: This study aim to investigate the oncological safety of neoadjuvant therapy (NAT) followed by breast-conserving surgery (BCS) for invasive ductal carcinoma (IDC) patients with the presence of ductal carcinoma <i>in situ</i> (DCIS) on pre-NAT biopsy. The data of women with IDC who underwent radical surgery between January 2013 and December 2021 were retrospectively reviewed from two institutions. The study endpoints were 5-year disease-free survival (DFS) and local recurrence-fee survival (LRFS). Overall, 994 eligible patients were enrolled. Patients with IDC with DCIS (<i>n</i> = 277) and patients undergoing BCS (<i>n</i> = 285) were selected separately for prognostic analysis. For patients with IDC with DCIS, the 5-year DFS (<i>p</i> = 0.517) and 5-year LRFS (<i>p</i> = 0.397) rates of the patients undergoing BCS were similar to those of patients undergoing mastectomy after propensity score matching. In addition, the 285 patients who underwent BCS were divided into the IDC + DCIS and IDC groups. The 5-year DFS (<i>p</i> = 0.394) and 5-year LRFS (<i>p</i> = 0.341) rates were similar between the IDC and IDC + DCIS groups. NAT followed by BCS combined with adjuvant radiotherapy is a safe and feasible treatment option in patients with IDC with DCIS under the premise of strict adherence to the surgical indications and adequate incision margins.
DOI: 10.6084/m9.figshare.28330815
title: Effects of Hsa-miR-4741/LILRB2 on Senescence of Nucleus Pulposus Cells and Their Prognostic Values in Lumbar Disc Herniation

description: The incidence of lumbar disk herniation (LDH) is usually caused by lumbar disk degeneration. Surgery is a common treatment strategy for LDH, but it can recur, resulting in recurrent disk herniation (RDH). To explore the predictive value of hsa-miR-4741 and LILRB2 in the prognosis of LDH surgery and the mechanism of nucleus pulposus senescence. The ROC curves of RDH based on hsa-miR-4741 and LILRB2 were constructed to evaluate their predictive values in the prognosis of LDH surgery. Human nucleus pulposus cells (NPC) was treated by TNF-α to construct a cell senescence model, studying the senescence mechanism. Oxidative stress and senescence markers were detected after overexpression of hsa-miR-4741 and LILRB2 to evaluate their effects on the senescence of NPC. Dual luciferase assay and the transfection of hsa-miR-4741 mimics or inhibitor were used to investigate the targeted regulation of it to LILRB2. The combination of hsa-miR-4741 and LILRB2 showed higher accuracy in predicting the outcome of RDH (AUC = 0.9367), compared with a single molecule. Overexpression of hsa-miR-4741 enhanced TNF-α-induced oxidative stress and senescence, while LILRB2 overexpression had the opposite effect. Hsa-miR-4741 mimics attenuated the luciferase activity of NPC transfected with wt-LILRB2 vector and significantly down-regulated LILRB2 expression. In addition, the antioxidant NAC reversed the promotion of hsa-miR-4741 on NPC senescence. The combination of hsa-miR-4741 and LILRB2 was a good predictor of LDH prognosis. Hsa-miR-4741 promoted oxidative stress-induced NPC senescence by negatively regulating LILRB2. Hsa-miR-4741 was abnormally expressed in LDH patients, while LILRB2 expression was absent.Hsa-miR-4741 combined with LILRB2 can well predict the postoperative outcome of LDH patients.Hsa-miR-4741 promoted oxidative stress-induced senescence of human nucleus pulposus cells by negatively regulating LILRB2. Hsa-miR-4741 was abnormally expressed in LDH patients, while LILRB2 expression was absent. Hsa-miR-4741 combined with LILRB2 can well predict the postoperative outcome of LDH patients. Hsa-miR-4741 promoted oxidative stress-induced senescence of human nucleus pulposus cells by negatively regulating LILRB2.
DOI: 10.6084/m9.figshare.28330815.v1
title: Effects of Hsa-miR-4741/LILRB2 on Senescence of Nucleus Pulposus Cells and Their Prognostic Values in Lumbar Disc Herniation

description: The incidence of lumbar disk herniation (LDH) is usually caused by lumbar disk degeneration. Surgery is a common treatment strategy for LDH, but it can recur, resulting in recurrent disk herniation (RDH). To explore the predictive value of hsa-miR-4741 and LILRB2 in the prognosis of LDH surgery and the mechanism of nucleus pulposus senescence. The ROC curves of RDH based on hsa-miR-4741 and LILRB2 were constructed to evaluate their predictive values in the prognosis of LDH surgery. Human nucleus pulposus cells (NPC) was treated by TNF-α to construct a cell senescence model, studying the senescence mechanism. Oxidative stress and senescence markers were detected after overexpression of hsa-miR-4741 and LILRB2 to evaluate their effects on the senescence of NPC. Dual luciferase assay and the transfection of hsa-miR-4741 mimics or inhibitor were used to investigate the targeted regulation of it to LILRB2. The combination of hsa-miR-4741 and LILRB2 showed higher accuracy in predicting the outcome of RDH (AUC = 0.9367), compared with a single molecule. Overexpression of hsa-miR-4741 enhanced TNF-α-induced oxidative stress and senescence, while LILRB2 overexpression had the opposite effect. Hsa-miR-4741 mimics attenuated the luciferase activity of NPC transfected with wt-LILRB2 vector and significantly down-regulated LILRB2 expression. In addition, the antioxidant NAC reversed the promotion of hsa-miR-4741 on NPC senescence. The combination of hsa-miR-4741 and LILRB2 was a good predictor of LDH prognosis. Hsa-miR-4741 promoted oxidative stress-induced NPC senescence by negatively regulating LILRB2. Hsa-miR-4741 was abnormally expressed in LDH patients, while LILRB2 expression was absent.Hsa-miR-4741 combined with LILRB2 can well predict the postoperative outcome of LDH patients.Hsa-miR-4741 promoted oxidative stress-induced senescence of human nucleus pulposus cells by negatively regulating LILRB2. Hsa-miR-4741 was abnormally expressed in LDH patients, while LILRB2 expression was absent. Hsa-miR-4741 combined with LILRB2 can well predict the postoperative outcome of LDH patients. Hsa-miR-4741 promoted oxidative stress-induced senescence of human nucleus pulposus cells by negatively regulating LILRB2.
DOI: 10.6084/m9.figshare.29346745
title: Neutrophil-to-Hemoglobin Ratio and Monocyte-to-Hemoglobin Ratio Predict Prolonged Length of Stay in Patients Undergoing Surgery for Pelvic or Acetabular Fractures

description: This study evaluated the neutrophil-to-hemoglobin ratio (NHR) and monocyte-to-hemoglobin ratio (MHR) as predictors of prolonged hospital stay in patients undergoing surgery for pelvic or acetabular fractures. We retrospectively reviewed records of patients aged ≥ 18 years who underwent open reduction and internal fixation (ORIF). NHR and MHR were calculated from blood samples at admission and 24 hours postoperatively. Prolonged hospital length of stay (LOS) was defined as ≥ 25 days (75th percentile). Optimal cutoffs were determined by ROC curve analysis. Multivariable logistic regression identified associations between clinical variables and prolonged LOS. Among 172 patients (mean age 44.5), postoperative NHR &gt; 0.46 and MHR &gt; 0.02 were independently associated with prolonged LOS in patients with acetabular fractures (aOR = 5.90 and 5.42, respectively). No significant associations were found in pelvic fractures. Elevated postoperative NHR and MHR are strongly associated with prolonged LOS in patients with acetabular fractures and may assist in perioperative risk stratification and clinical decision-making.
DOI: 10.6084/m9.figshare.29346745.v1
title: Neutrophil-to-Hemoglobin Ratio and Monocyte-to-Hemoglobin Ratio Predict Prolonged Length of Stay in Patients Undergoing Surgery for Pelvic or Acetabular Fractures

description: This study evaluated the neutrophil-to-hemoglobin ratio (NHR) and monocyte-to-hemoglobin ratio (MHR) as predictors of prolonged hospital stay in patients undergoing surgery for pelvic or acetabular fractures. We retrospectively reviewed records of patients aged ≥ 18 years who underwent open reduction and internal fixation (ORIF). NHR and MHR were calculated from blood samples at admission and 24 hours postoperatively. Prolonged hospital length of stay (LOS) was defined as ≥ 25 days (75th percentile). Optimal cutoffs were determined by ROC curve analysis. Multivariable logistic regression identified associations between clinical variables and prolonged LOS. Among 172 patients (mean age 44.5), postoperative NHR &gt; 0.46 and MHR &gt; 0.02 were independently associated with prolonged LOS in patients with acetabular fractures (aOR = 5.90 and 5.42, respectively). No significant associations were found in pelvic fractures. Elevated postoperative NHR and MHR are strongly associated with prolonged LOS in patients with acetabular fractures and may assist in perioperative risk stratification and clinical decision-making.
DOI: 10.6084/m9.figshare.30454570
title: Modified Intrascleral Suture Technique for Repairing Iridodialysis Combined with Phacoemulsification Cataract Surgery

description: To introduce a modified intrascleral suture technique (MIST) for repairing iridodialysis combined with phacoemulsification cataract surgery and evaluate its efficacy. We retrospectively analyzed the clinical characteristics and surgical outcomes of patients undergoing iridodialysis repair and cataract surgery (2018–2023). Twelve eyes received MIST, and eleven received the modified sewing-machine technique (MSMT). Both techniques utilized the closed-chamber sewing-machine principle of suture loop formation. MIST utilized a 10-0 polypropylene suture with long straight and short curved needles, guided by a 26-gauge syringe tip for intrascleral suturing. MSMT involved creating a partial-thickness scleral tunnel, through which a prethreaded needle with 10-0 polypropylene suture was passed for fixation. Iridodialysis was successfully repaired in all patients. The median procedure time was significantly shorter in the MIST group (25 min, IQR: 24.0–27.5) than in the MSMT group (34 min, IQR: 29.0–35.0; <i>p</i> &lt; 0.0001). Although postoperative day 1 best-corrected visual acuity (BCVA) did not differ significantly between groups (<i>p</i> = 0.08), the median BCVA was better in the MIST group (0.1 logMAR, IQR: 0.0–0.4) than the MSMT group (0.4 logMAR, IQR: 0.1–0.6). Complication rates were comparable between groups. The MIST technique provides a minimally invasive alternative for iridodialysis repair by eliminating the need for conjunctival or scleral dissection. This approach significantly reduces operative time while maintaining surgical efficacy and safety, making it a valuable option for combined iridodialysis and cataract surgery.
DOI: 10.6084/m9.figshare.30454570.v1
title: Modified Intrascleral Suture Technique for Repairing Iridodialysis Combined with Phacoemulsification Cataract Surgery

description: To introduce a modified intrascleral suture technique (MIST) for repairing iridodialysis combined with phacoemulsification cataract surgery and evaluate its efficacy. We retrospectively analyzed the clinical characteristics and surgical outcomes of patients undergoing iridodialysis repair and cataract surgery (2018–2023). Twelve eyes received MIST, and eleven received the modified sewing-machine technique (MSMT). Both techniques utilized the closed-chamber sewing-machine principle of suture loop formation. MIST utilized a 10-0 polypropylene suture with long straight and short curved needles, guided by a 26-gauge syringe tip for intrascleral suturing. MSMT involved creating a partial-thickness scleral tunnel, through which a prethreaded needle with 10-0 polypropylene suture was passed for fixation. Iridodialysis was successfully repaired in all patients. The median procedure time was significantly shorter in the MIST group (25 min, IQR: 24.0–27.5) than in the MSMT group (34 min, IQR: 29.0–35.0; <i>p</i> &lt; 0.0001). Although postoperative day 1 best-corrected visual acuity (BCVA) did not differ significantly between groups (<i>p</i> = 0.08), the median BCVA was better in the MIST group (0.1 logMAR, IQR: 0.0–0.4) than the MSMT group (0.4 logMAR, IQR: 0.1–0.6). Complication rates were comparable between groups. The MIST technique provides a minimally invasive alternative for iridodialysis repair by eliminating the need for conjunctival or scleral dissection. This approach significantly reduces operative time while maintaining surgical efficacy and safety, making it a valuable option for combined iridodialysis and cataract surgery.
DOI: 10.15468/dl.nvgw57
title: Occurrence Download

description: A dataset containing 60 records in GBIF matching the query:
SELECT
 kingdom,
 kingdomkey,
 phylum,
 phylumkey,
 class,
 classkey,
 "order",
 orderkey,
 family,
 familykey,
 genus,
 genuskey,
 species,
 specieskey,
 "year",
 IF(ISNULL(kingdomkey), NULL, SUM(COUNT(*)) OVER (
 PARTITION BY kingdomkey, "year")) kingdomcount,
 IF(ISNULL(phylumkey), NULL, SUM(COUNT(*)) OVER (
 PARTITION BY phylumkey, "year")) phylumcount,
 IF(ISNULL(classkey), NULL, SUM(COUNT(*)) OVER (
 PARTITION BY classkey, "year")) classcount,
 IF(ISNULL(orderkey), NULL, SUM(COUNT(*)) OVER (
 PARTITION BY orderkey, "year")) ordercount,
 IF(ISNULL(familykey), NULL, SUM(COUNT(*)) OVER (
 PARTITION BY familykey, "year")) familycount,
 IF(ISNULL(genuskey), NULL, SUM(COUNT(*)) OVER (
 PARTITION BY genuskey, "year")) genuscount,
 COUNT(*) occurrences,
 MIN(GBIF_TEMPORALUNCERTAINTY(eventdate, eventtime)) mintemporaluncertainty,
 MIN(COALESCE(coordinateuncertaintyinmeters, 1000)) mincoordinateuncertaintyinmeters
FROM
 occurrence
WHERE
 (occurrence.taxonkey IN ('5787236', '5219401', '7193911', '9017563', '6164652', '9546725') OR occurrence.acceptedtaxonkey IN ('5787236', '5219401', '7193911', '9017563', '6164652', '9546725') OR occurrence.kingdomkey IN ('5787236', '5219401', '7193911', '9017563', '6164652', '9546725') OR occurrence.phylumkey IN ('5787236', '5219401', '7193911', '9017563', '6164652', '9546725') OR occurrence.classkey IN ('5787236', '5219401', '7193911', '9017563', '6164652', '9546725') OR occurrence.orderkey IN ('5787236', '5219401', '7193911', '9017563', '6164652', '9546725') OR occurrence.familykey IN ('5787236', '5219401', '7193911', '9017563', '6164652', '9546725') OR occurrence.genuskey IN ('5787236', '5219401', '7193911', '9017563', '6164652', '9546725') OR occurrence.specieskey IN ('5787236', '5219401', '7193911', '9017563', '6164652', '9546725'))
 AND occurrence.hasgeospatialissues = FALSE
 AND NOT GBIF_STRINGARRAYCONTAINS(occurrence.issue, 'TAXON_MATCH_FUZZY', TRUE)
 AND (occurrence.distancefromcentroidinmeters &gt;= 2000.0 OR occurrence.distancefromcentroidinmeters IS NULL)
 AND NOT occurrence.basisofrecord IN ('FOSSIL_SPECIMEN', 'LIVING_SPECIMEN')
 AND occurrence.occurrencestatus = 'PRESENT'
 AND (occurrence.specieskey IS NOT NULL AND occurrence."year" IS NOT NULL)
GROUP BY
 occurrence.kingdom,
 occurrence.kingdomkey,
 occurrence.phylum,
 occurrence.phylumkey,
 occurrence.class,
 occurrence.classkey,
 occurrence."order",
 occurrence.orderkey,
 occurrence.family,
 occurrence.familykey,
 occurrence.genus,
 occurrence.genuskey,
 occurrence.species,
 occurrence.specieskey,
 occurrence."year"

 The dataset's 60 records were derived from 24 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0047126-251120083545085/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.60656/6ad016517ee4485c
title: Custom collection of categorize, classification, disdrometer, drizzle, droplet effective radius, and 10 other products from Limassol between 1 Jan and 11 Dec 2025
DOI: 10.6084/m9.figshare.29389936
title: The Safety of Primary Anastomosis Without Protective Stoma in Emergency Left Colon Surgery: A Meta-Analysis

description: This study aims to evaluate the safety of primary anastomosis (PA) without a protective stoma in emergency left colon surgery. A systematic search was conducted in the PubMed, Web of Science, Embase, and Cochrane Library databases, covering articles from the inception of these databases until September 2024. The primary outcome was the incidence of anastomotic leakage. The PA group exhibited a higher incidence of anastomotic leakage compared to the stoma surgery group (odds ratios (OR) = 5.86, <i>p</i> = 0.05). However, in cases of perforated diverticulitis (OR = 3.80, <i>p</i> = 0.19) and malignant obstruction (OR = 5.40, <i>p</i> = 0.23), the PA group did not show an increased risk of anastomotic leakage. In terms of other outcomes, the reoperation rate in the PA group was higher compared to the stoma surgery group (OR = 1.89, <i>p</i> &lt; 0.001). However, there were no statistically significant differences in the mortality rate (OR = 1.04, <i>p</i> = 0.80) or the incidence of postoperative complications (OR = 1.50, <i>p</i> = 0.27) between the two groups. Primary anastomosis without a protective stoma is generally safe and can be considered a viable option in emergency left colon surgery.
DOI: 10.6084/m9.figshare.29389936.v1
title: The Safety of Primary Anastomosis Without Protective Stoma in Emergency Left Colon Surgery: A Meta-Analysis

description: This study aims to evaluate the safety of primary anastomosis (PA) without a protective stoma in emergency left colon surgery. A systematic search was conducted in the PubMed, Web of Science, Embase, and Cochrane Library databases, covering articles from the inception of these databases until September 2024. The primary outcome was the incidence of anastomotic leakage. The PA group exhibited a higher incidence of anastomotic leakage compared to the stoma surgery group (odds ratios (OR) = 5.86, <i>p</i> = 0.05). However, in cases of perforated diverticulitis (OR = 3.80, <i>p</i> = 0.19) and malignant obstruction (OR = 5.40, <i>p</i> = 0.23), the PA group did not show an increased risk of anastomotic leakage. In terms of other outcomes, the reoperation rate in the PA group was higher compared to the stoma surgery group (OR = 1.89, <i>p</i> &lt; 0.001). However, there were no statistically significant differences in the mortality rate (OR = 1.04, <i>p</i> = 0.80) or the incidence of postoperative complications (OR = 1.50, <i>p</i> = 0.27) between the two groups. Primary anastomosis without a protective stoma is generally safe and can be considered a viable option in emergency left colon surgery.
DOI: 10.6084/m9.figshare.28416952
title: Deciphering the Function of lncRNA XIST/miR-329-3p/TMBIM6 Axis in the Proliferation of Non-Small Cell Lung Cancer

description: Non-small cell lung cancer (NSCLC) remains a major health concern due to its high incidence and mortality rates. This study aimed to investigate the role and underlying mechanism of the long non-coding X inactivation-specific transcript (lncRNA XIST)/microRNA-329-3p (miR-329-3p)/transmembrane BAX Inhibitor Motif-6 (TMBIM6) axis in the proliferation, migration, and invasion of NSCLC, and its potential as a therapeutic target. The expression levels of XIST, miR-329-3p, and TMBIM6 in NSCLC tissues and cell lines were assessed using quantitative real-time PCR (qRT-PCR), and their correlations with clinicopathological characteristics were examined. Dual-luciferase reporter assays and RNA immunoprecipitation (RIP) were used to validate the binding interactions among XIST and miR-329-3p, and TMBIM6. The malignant phenotypes of NSCLC cells, including proliferation, migration, invasion, and apoptosis, were assessed using CCK-8, Transwell assays, and flow cytometry. Silencing XIST significantly suppressed the proliferation, migration, and invasion of NSCLC cells while promoting apoptosis. Mechanistically, XIST functioned as a competitive endogenous RNA (ceRNA), sponging miR-329-3p and thereby downregulating its expression. Overexpression of miR-329-3p counteracted the oncogenic effects of XIST in NSCLC cells. Additionally, miR-329-3p downregulated TMBIM6 expression, while TMBIM6 overexpression counteracted the tumor-suppressive effects of miR-329-3p. Silencing XIST upregulates miR-329-3p, leading to the suppression of TMBIM6 expression and inhibition of NSCLC progression. These findings suggest that the XIST/miR-329-3p/TMBIM6 axis could serve as a promising molecular target for therapeutic strategies in NSCLC.
DOI: 10.6084/m9.figshare.28416952.v1
title: Deciphering the Function of lncRNA XIST/miR-329-3p/TMBIM6 Axis in the Proliferation of Non-Small Cell Lung Cancer

description: Non-small cell lung cancer (NSCLC) remains a major health concern due to its high incidence and mortality rates. This study aimed to investigate the role and underlying mechanism of the long non-coding X inactivation-specific transcript (lncRNA XIST)/microRNA-329-3p (miR-329-3p)/transmembrane BAX Inhibitor Motif-6 (TMBIM6) axis in the proliferation, migration, and invasion of NSCLC, and its potential as a therapeutic target. The expression levels of XIST, miR-329-3p, and TMBIM6 in NSCLC tissues and cell lines were assessed using quantitative real-time PCR (qRT-PCR), and their correlations with clinicopathological characteristics were examined. Dual-luciferase reporter assays and RNA immunoprecipitation (RIP) were used to validate the binding interactions among XIST and miR-329-3p, and TMBIM6. The malignant phenotypes of NSCLC cells, including proliferation, migration, invasion, and apoptosis, were assessed using CCK-8, Transwell assays, and flow cytometry. Silencing XIST significantly suppressed the proliferation, migration, and invasion of NSCLC cells while promoting apoptosis. Mechanistically, XIST functioned as a competitive endogenous RNA (ceRNA), sponging miR-329-3p and thereby downregulating its expression. Overexpression of miR-329-3p counteracted the oncogenic effects of XIST in NSCLC cells. Additionally, miR-329-3p downregulated TMBIM6 expression, while TMBIM6 overexpression counteracted the tumor-suppressive effects of miR-329-3p. Silencing XIST upregulates miR-329-3p, leading to the suppression of TMBIM6 expression and inhibition of NSCLC progression. These findings suggest that the XIST/miR-329-3p/TMBIM6 axis could serve as a promising molecular target for therapeutic strategies in NSCLC.
DOI: 10.57680/asep.0643052
title: Růstové parametry mikrořas
title: Microalgae growth parameters

description: Tabulky s hodnotami sušiny, optické hustoty, konduktivity, změny pH, obsahu pigmentů sinic Trichormus, Nostoc a Desmonostoc pro stanovení fyziologického stavu buněk a optimálních růstových podmínek během přechodu z laboratorních podmínek k pilotní venkovní kultivaci tohoto kmene ve větším objemu (20L).
description: Tables with values of dry matter, optical density, conductivity, pH change, pigment content of cyanobacteria Trichormus, Nostoc and Desmonostoc for determining the physiological state of cells and optimal growth conditions during the transition from laboratory conditions to pilot outdoor cultivation of this strain in a larger volume (20L).
DOI: 10.15468/dl.4n6jm5
title: Occurrence Download

description: A dataset containing 9308 species occurrences available in GBIF matching the query:
{
 "and" : [
 "CoordinateUncertaintyInMeters 0.0-1000.0",
 "Geometry POLYGON((-6.25617 41.0851,27.48128 41.0851,27.48128 72.26782,-6.25617 72.26782,-6.25617 41.0851))",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "TaxonKey is Cryptogramma crispa"
 ]
}

 The dataset includes 9308 records from 156 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0047146-251120083545085/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.5281/zenodo.17899559
title: Binders in Biomass Pelletization and Combustion Analysis
DOI: 10.5281/zenodo.17899560
title: Binders in Biomass Pelletization and Combustion Analysis