cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.5061/dryad.kc688
title: Data from: How much would it cost to monitor farmland biodiversity in Europe?

description: To evaluate progress on political biodiversity objectives, biodiversity
 monitoring provides information on whether intended results are being
 achieved. Despite scientific proof that monitoring and evaluation increase
 the (cost) efficiency of policy measures, cost estimates for monitoring
 schemes are seldom available, hampering their inclusion in policy
 programme budgets. Empirical data collected from 12 case studies across
 Europe were used in a power analysis to estimate the number of farms that
 would need to be sampled per major farm type to detect changes in species
 richness over time for four taxa (vascular plants, earthworms, spiders and
 bees). A sampling design was developed to allocate spatially, across
 Europe, the farms that should be sampled. Cost estimates are provided for
 nine monitoring scenarios with differing robustness for detecting temporal
 changes in species numbers. These cost estimates are compared with the
 Common Agricultural Policy (CAP) budget (2014–2020) to determine the
 budget allocation required for the proposed farmland biodiversity
 monitoring. Results show that the bee indicator requires the highest
 number of farms to be sampled and the vascular plant indicator the lowest.
 The costs for the nine farmland biodiversity monitoring scenarios
 corresponded to 0·01%–0·74% of the total CAP budget and to 0·04%–2·48% of
 the CAP budget specifically allocated to environmental targets. Synthesis
 and applications. The results of the cost scenarios demonstrate that,
 based on the taxa and methods used in this study, a Europe-wide farmland
 biodiversity monitoring scheme would require a modest share of the Common
 Agricultural Policy budget. The monitoring scenarios are flexible and can
 be adapted or complemented with alternate data collection options (e.g. at
 national scale or voluntary efforts), data mobilization, data integration
 or modelling efforts.
description: Farmland species
 richness dataData contains species
 richness of plants, earthworm, spiders and bees (wild bees and bumblebees)
 in 195 farms in 12 study regions in Europe. The observed species richness
 are complemented by a 5% lower and a 95% upper confidence level derived
 from species accumulation as well as the number of samples drawn in each
 farm.Geijzendorffer_et_al_2015_farm_species_richness.csv
DOI: 10.5281/zenodo.18377415
title: Comprehensive Dataset of Fast-Disintegrating Tablet (FDT) Formulations (2010–2025): APIs, Excipients, and Tablet Properties

description: This dataset provides a comprehensive collection of fast-disintegrating tablet (FDT) formulations published between 2010 and 2025. It includes detailed information on active pharmaceutical ingredients (APIs), excipients (with quantitative amounts in milligrams), and formulation properties such as disintegration time, hardness, friability, and drug content.

It represents an updated and extended version of previous datasets (2010–2020), compiled and standardized to cover all relevant formulations up to 2025. The dataset is independent and suitable for research in formulation design, data-driven modeling, and machine learning for pharmaceutical development.

Each excipient column reports the amount in milligrams (mg) used in a formulation, with 0 indicating that the excipient was not used.
DOI: 10.5281/zenodo.17395167
title: Comprehensive Dataset of Fast-Disintegrating Tablet (FDT) Formulations (2010–2025): APIs, Excipients, and Tablet Properties

description: This dataset provides a comprehensive collection of fast-disintegrating tablet (FDT) formulations published between 2010 and 2025. It includes detailed information on active pharmaceutical ingredients (APIs), excipients (with quantitative amounts in milligrams), and formulation properties such as disintegration time, hardness, friability, and drug content.

It represents an updated and extended version of previous datasets (2010–2020), compiled and standardized to cover all relevant formulations up to 2025. The dataset is independent and suitable for research in formulation design, data-driven modeling, and machine learning for pharmaceutical development.

Each excipient column reports the amount in milligrams (mg) used in a formulation, with 0 indicating that the excipient was not used.
DOI: 10.5061/dryad.p170v
title: Data from: Respiratory virus infection up-regulates TRPV1, TRPA1 and ASICS3 receptors on airway cells

description: Receptors implicated in cough hypersensitivity are transient receptor
 potential vanilloid 1 (TRPV1), transient receptor potential cation
 channel, Subfamily A, Member 1 (TRPA1) and acid sensing ion channel
 receptor 3 (ASIC3). Respiratory viruses, such as respiratory syncytial
 virus (RSV) and measles virus (MV) may interact directly and/or indirectly
 with these receptors on sensory nerves and epithelial cells in the
 airways. We used in vitro models of sensory neurones (SHSY5Y or
 differentiated IMR-32 cells) and human bronchial epithelium (BEAS-2B
 cells) as well as primary human bronchial epithelial cells (PBEC) to study
 the effect of MV and RSV infection on receptor expression. Receptor mRNA
 and protein levels were examined by qPCR and flow cytometry, respectively,
 following infection or treatment with UV inactivated virus, virus-induced
 soluble factors or pelleted virus. Concentrations of a range of cytokines
 in resultant BEAS-2B and PBEC supernatants were determined by ELISA.
 Up-regulation of TRPV1, TRPA1 and ASICS3 expression occurred by 12 hours
 post-infection in each cell type. This was independent of replicating
 virus, within the same cell, as virus-induced soluble factors alone were
 sufficient to increase channel expression. IL-8 and IL-6 increased in
 infected cell supernatants. Antibodies against these factors inhibited TRP
 receptor up-regulation. Capsazepine treatment inhibited virus induced
 up-regulation of TRPV1 indicating that these receptors are targets for
 treating virus-induced cough.
description: Omar et al data
 tablesData files for graphical
 figures with SDs
DOI: 10.5061/dryad.6g8n1
title: Data from: Patterns and drivers of biodiversity-stability relationships under climate extremes

description: Interactions between biodiversity loss and climate change present
 significant challenges for research, policy and management of ecosystems.
 Evidence suggests that high species diversity tends to increase plant
 community stability under interannual climate fluctuations and mild dry
 and wet events, but the overall pattern of diversity–stability
 relationships under climate extremes is unclear. We comprehensively review
 results from observational and experimental studies to assess the
 importance of diversity effects for ecosystem function under climate
 extremes. Both the broad literature review and a meta-analysis focused on
 the effects of extreme precipitation events on above-ground biomass reveal
 no significant interaction between species richness and climate extremes.
 Causes for variation in diversity effects under climate extremes are
 explored, from stress thresholds to biotic interactions and community
 assembly, and we consider how these may modulate the outcomes of
 biodiversity–stability relationships. We also examine how specific
 characteristics of climate extremes and timing of measurements may
 interact with mechanisms of diversity–stability relationships. Synthesis.
 Hypotheses tailored to the complexity of diversity effects, the
 implementation of standardised experiments and the use of trait-based
 biodiversity measures rather than species richness should lead to better
 causal understanding of whether and how biodiversity may protect
 ecosystems from adverse effects of climate extremes.
description: DeBoeck et al.
 meta-analysisData used in the
 meta-analysisDeBoecketalDryad.xlsx
DOI: 10.5061/dryad.32r3q
title: Data from: Biting disrupts integration to spur skull evolution in eels

description: The demand that anatomical structures work together to perform biological
 functions is thought to impose strong limits on morphological evolution.
 Breakthroughs in diversification can occur, however, when functional
 integration among structures is relaxed. Although such transitions are
 expected to generate variation in morphological diversification across the
 tree of life, empirical tests of this hypothesis are rare. Here we show
 that transitions between suction-based and biting modes of prey capture,
 which require different degrees of coordination among skull components,
 are associated with shifts in the pattern of skull diversification in eels
 (Anguilliformes). Biting eels have experienced greater independence of the
 jaws, hyoid and operculum during evolution and exhibit more varied
 morphologies than closely related suction feeders, and this pattern
 reflects the weakened functional integration among skull components
 required for biting. Our results suggest that behavioural transitions can
 change the evolutionary potential of the vertebrate skeleton by altering
 functional relationships among structures.
description: Morphological data for
 62 species of elopomorph fishThe data file contains
 morphological measurements for aspects of the cranial skeleton from
 individual specimens representing 59 eels (Anguilliformes) plus three
 non-anguilliform elopomorph fishes.elopomorph.data.csv
DOI: 10.5061/dryad.b7fs1j3
title: Data from: Diagnostic accuracy of point shear wave elastography and transient elastography for staging hepatic fibrosis in patients with non-alcoholic fatty liver disease: a meta-analysis

description: Objective: This study aimed to assess the accuracy of staging liver
 fibrosis in Non-Alcoholic Fatty Liver Disease Patients (NAFLD) via Point
 shear wave Elastography (pSWE) and Transient Elastography (TE). Setting:
 Relevant records concerning NAFLD were retrieved from Pubmed, Embase, Web
 of Science, and the China National Knowledge Infrastructure databases up
 to 20th of December, 2017. A bivariate mixed-effects model was conducted
 to combine sensitivity (SE), specificity (SP), positive likelihood ratio
 (LR+), negative likelihood ratio (LR-) and Area Under Summary Receiver
 Operating Characteristic Curve (AUC) between TE and pSWE. A sensitivity
 analysis was implemented to explore the source of heterogeneity.
 Participants: Patients with NAFLD who had a liver stiffness measurement
 using pSWE and TE before liver biopsy were enrolled according to the
 following criteria : 2×2 contingency tables can be calculated via the
 reported numbers of cases, sensitivity and specificity and were excluded
 according to the following criteria: with histories of other hepatic
 damage, such as chronic hepatitis C, concurrent active hepatitis B
 infection, autoimmune hepatitis, suspicious drug usage, and alcohol abuse.
 Results: Nine pSWE studies comprising a total 982 of patients and eleven
 TE studies comprising a total of 1753 patients were included. For
 detection of significant fibrosis, advanced fibrosis and cirrhosis, the
 summary AUC were 0.86 (95% CI: 0.83–0.89), 0.94 (95% CI: 0.91–0.95) and
 0.95 (95% CI: 0.93–0.97) for pSWE and the summary AUC was 0.85 (95% CI:
 0.82–0.88), 0.92 (95% CI: 0.89–0.94) and 0.94 (95% CI: 0.93–0.97) for TE,
 respectively. The proportion of failure measurement was over tenfold as
 common with TE using an M probe compared to pSWE Conclusion: pSWE and TE,
 providing precise non-invasive staging of liver fibrosis in NAFLD, are
 promising techniques, particularly for advanced fibrosis and cirrhosis.
description: metaanalysis for
 diagnostic accuracyWe provide original data
 extracted from literature, the search strategy of this meta-analysis.The
 summary sensitivity, specificity, positive likelihood ratio, and negative
 likelihood ratio with their confidence intervals and heterogeneities and
 summary receiver operating characteristic curves for the pSWE and TE can
 be reached by itoriginal
 data_metaanalysis.rar
DOI: 10.5061/dryad.hb34s
title: Data from: Efficacy and safety of bevacizumab plus erlotinib versus bevacizumab or erlotinib alone in the treatment of non-small-cell lung cancer: a systematic review and meta-analysis

description: Objectives: Bevacizumab and erlotinib inhibit different tumour growth
 pathways, and both exhibit beneficial effects in the treatment of
 non-small-cell lung cancer (NSCLC). However, the efficacy of bevacizumab
 in combination with erlotinib remains controversial. Therefore, we
 conducted a meta-analysis to compare combination treatment with
 bevacizumab and erlotinib to bevacizumab or erlotinib monotherapy in the
 treatment of NSCLC. Methods: Randomised controlled trials (RCTs) published
 in PubMed, Web of Science and EMBASE were systematically reviewed. The
 main outcome measures included overall survival (OS), progression-free
 survival (PFS), overall response rate (ORR) and adverse events. Results
 were expressed as HRs or risk ratios (RRs) with 95% CIs. Results: 5 RCTs
 involving a total of 1736 patients were included in this meta-analysis.
 The combination of bevacizumab and erlotinib significantly improved PFS
 (HR=0.63, 95% CI 0.53 to 0.75; p=0.000) and the ORR (RR=1.91, 95% CI 1.19
 to 3.06; p=0.007) in the second-line treatment of NSCLC compared with
 bevacizumab or erlotinib alone. However, no significant difference in OS
 was observed between the combination and monotherapy groups (HR=0.96, 95%
 CI 0.83 to 1.11; p=0.573). A subgroup analysis has shown that the greatest
 PFS benefit was associated with an age of &lt;65 years(HR=0.74, 95% CI
 0.57 to 0.96; p=0.026), Asian/Pacific Islander ethnicity (HR=0.23, 95% CI
 0.10 to 0.54; p=0.001), Eastern Cooperative Oncology Group performance
 status (ECOG PS) 1 (HR=0.82, 95% CI 0.68 to 0.98; p=0.033), stage IIIB or
 IV disease (HR=0.68, 95% CI 0.57 to 0.82; p=0.000) and no history of
 smoking (HR=0.48, 95% CI 0.32 to 0.71; p=0.000). The incidence of grade
 3/4 adverse events such as rash and diarrhoea was higher in the
 combination group than in the monotherapy group. Conclusions: The addition
 of bevacizumab to erlotinib can significantly improve PFS and the ORR in
 the second-line treatment of NSCLC with an acceptable and manageable risk
 of rash and diarrhoea. Further well-conducted, large-scale trials are
 needed to validate these findings.
description: Data from: The efficacy
 and safety of bevacizumab plus erlotinib versus bevacizumab or
 erlotinibalone in the treatment of non-small-cell lung cancer: a
 systematic review and meta-analysisdata
 extraction-bmjopen-2016-011714.xlsx
DOI: 10.5061/dryad.6p9v5
title: Data from: Community assembly and functional diversity along succession post-management

description: 1. Despite extensive development of successional theory, few empirical
 studies have evaluated whether existing models are applicable to
 human-modified landscapes. Seasonally dry tropical forests are
 experiencing widespread transformation, and represent a critical system to
 assess in a successional framework to infer the mechanisms that shape
 assembly of secondary forests post-management. 2. We used a functional
 trait-based approach to assess changes in community assembly mechanisms
 along succession in secondary dry forests of varying stages following
 abandonment of cattle activity, as well as nearby old-growth forests. We
 evaluated whether re-assembly proceeded consistent with existing theory,
 in early successional stages via habitat filtering, leading to reduced
 trait range, and via competitive exclusion in later stages, leading to
 increased trait evenness. Using three orthogonal traits and two functional
 diversity indices we tested for evidence of assembly mechanisms along
 resource axes that may be particularly important to dry forest systems,
 dynamic changes in habitat filtering and competitive exclusion, and
 potential legacy effects of management. 3. We found little support of a
 progression from habitat filtering to competitive exclusion, with the
 exception of dispersion patterns for specific leaf area and multi-variate
 functional richness. Water may underlie species sorting in most stages, as
 evidenced by range reduction in wood density, and might be a resource
 particularly important to dry forest assembly. Early successional stages
 displayed an unexpected pattern of low evenness, which may be due to
 initial stand composition including remnants and resprouts, a regeneration
 strategy typical to dry forest species. Beyond influencing initial
 conditions, management legacy was apparent in late secondary forests,
 which differed in range, even dispersion, and functional richness from
 old-growth forests, suggesting the operation of different assembly
 mechanisms. 4. The departures from expectations suggest the need to
 re-assess successional models to include effects of management legacies on
 the operation of community assembly mechanisms in human-modified
 landscapes, as well as characteristics that distinguish wet and dry forest
 dynamics.
description: TraitDatDRYADSpecies list and mean trait values for each species x stage included in the study
DOI: 10.5061/dryad.hr348
title: Data from: Matrix composition and patch edges influence plant-herbivore interactions in marine landscapes

description: The functioning of ecosystems can be strongly driven by landscape
 attributes. Despite its importance, however, our understanding of how
 landscape influences ecosystem function derives mostly from species
 richness and abundance patterns, with few studies assessing how these
 relate to actual functional rates. We examined the influence of landscape
 attributes on the rates of herbivory in seagrass meadows, where herbivory
 has been identified as a key process structuring these relatively simple
 systems. The study was conducted in three representative Posidonia
 oceanica meadows. The principal herbivores in these meadows are the fish
 Sarpa salpa and the sea urchin Paracentrotus lividus, and we hypothesised
 that differences in their interaction with landscape attributes would
 significantly influence herbivory rates. We measured herbivore abundance,
 herbivory rates, primary production and plant quality (C:N) in seagrass
 patches embedded either in rock or in sand (matrix attribute), in patches
 either near or far from a rocky reef (distance attribute) and at the edges
 and interior of meadows. Our results show that matrix and meadow edges
 significantly affected the actual levels of herbivory. Herbivory rates
 were higher in seagrass patches embedded in a rocky matrix compared to
 those on sand, and herbivory at the centre of seagrass meadows was higher
 than at the edges. In contrast, patch distance to rocky reefs did not
 affect herbivory. Neither herbivore abundance nor food quality explained
 the patterns across different landscape attributes. This suggests that
 variation in herbivory across the landscape may be related much more to
 behavioural differences between species in their evaluation of risk,
 movement, and food preference in relation to the landscape structure. Our
 results indicate that richness and abundance patterns may mask critical
 interactions between landscape attributes and species responses, which
 result in considerable heterogeneity in the way key functional processes
 like herbivory are distributed across the ecosystem mosaic.
description: Data from: Matrix
 composition and patch edges influence plant-herbivore interactions in
 marine landscapesEcological data from
 seagrass meadows located in the NW Mediterranean Sea.herbivory_seascape.zip
DOI: 10.5061/dryad.4rs855v
title: Data from: Pollinator-mediated interactions between cultivated papaya and co-flowering plant species

description: Many modern crop varieties rely on animal pollination to set fruit and
 seeds. Intensive crop plantations usually do not provide suitable habitats
 for pollinators so crop yield may depend on the surrounding vegetation to
 maintain pollination services. However, little is known about the effect
 of pollinator-mediated interactions among co-flowering plants on crop
 yield or the underlying mechanisms. Plant reproductive success is complex,
 involving several pre- and post-pollination events; however, the current
 literature has mainly focused on pre-pollination events in natural plant
 communities. We assessed pollinator sharing and the contribution to
 pollinator diet in a community of wild and cultivated plants that
 co-flower with a focal papaya plantation. In addition, we assessed
 heterospecific pollen transfer to the stigmatic loads of papaya and its
 effect on fruit and seed production. We found that papaya shared at least
 one pollinator species with the majority of the co-flowering plants.
 Despite this, heterospecific pollen transfer in cultivated papaya was low
 in open-pollinated flowers. Hand pollination experiments suggest that
 heterospecific pollen transfer has no negative effect on fruit production
 or weight, but does reduce seed production. These results suggest that
 co-flowering plants offer valuable floral resources to pollinators that
 are shared with cultivated papaya with little or no cost in terms of
 heterospecific pollen transfer. Although HP reduced seed production, a
 reduced number of seeds per se is not negative, given that from an
 agronomic perspective the number of seeds does not affect the monetary
 value of the papaya fruit.
description: Data sets
 Badillo-Montaño et alRaw data of:
 plant-pollination visits, pollen loads and hand
 pollinationsDataBadilloetal.xlsx