cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.1367717.v1
title: β2 adrenergic receptor, protein kinase A (PKA) and c-Jun N-terminal kinase (JNK) signaling pathways mediate tau pathology in Alzheimer disease models.

description: Alzheimer disease (AD) is characterized by neurodegeneration marked by loss of synapses and spines associated with hyperphosphorylation of tau protein. Accumulating amyloid β peptide (Aβ) in brain is linked to neurofibrillary tangles composed of hyperphosphorylated tau in AD. Here, we identify β2-adrenergic receptor (β2AR) that mediates Aβ-induced tau pathology. In the prefrontal cortex (PFC) of 1-year-old transgenic mice with human familial mutant genes of presenilin 1 and amyloid precursor protein (PS1/APP), the phosphorylation of tau at Ser-214 Ser-262 and Thr-181, and the protein kinases including JNK, GSK3α/β, and Ca(2+)/calmodulin-dependent protein kinase II is increased significantly. Deletion of the β2AR gene in PS1/APP mice greatly decreases the phosphorylation of these proteins. Further analysis reveals that in primary PFC neurons, Aβ signals through a β2AR-PKA-JNK pathway, which is responsible for most of the phosphorylation of tau at Ser-214 and Ser-262 and a significant portion of phosphorylation at Thr-181. Aβ also induces a β2AR-dependent arrestin-ERK1/2 activity that does not participate in phosphorylation of tau. However, inhibition of the activity of MEK, an upstream enzyme of ERK1/2, partially blocks Aβ-induced tau phosphorylation at Thr-181. The density of dendritic spines and synapses is decreased in the deep layer of the PFC of 1-year-old PS1/APP mice, and the mice exhibit impairment of learning and memory in a novel object recognition paradigm. Deletion of the β2AR gene ameliorates pathological effects in these senile PS1/APP mice. The study indicates that β2AR may represent a potential therapeutic target for preventing the development of AD.
DOI: 10.6084/m9.figshare.1367597
title: Gaussian Job Archive for C13H24AlLiO3

description: Archive of work produced using the resources of the Imperial College High Performance Computing Service.
DOI: 10.6084/m9.figshare.1367597.v1
title: Gaussian Job Archive for C13H24AlLiO3

description: Archive of work produced using the resources of the Imperial College High Performance Computing Service.
DOI: 10.6084/m9.figshare.1367546
title: Cumulative PLOS ALM Report - January 2015

description: The PLOS ALM report contains the cumulative stats through January 2015.
DOI: 10.6084/m9.figshare.1367546.v1
title: Cumulative PLOS ALM Report - January 2015

description: The PLOS ALM report contains the cumulative stats through January 2015.
DOI: 10.6084/m9.figshare.1367535
title: Cumulative PLOS ALM Report - February 2015

description: The PLOS ALM report contains the cumulative stats through February 2015.
DOI: 10.6084/m9.figshare.1367535.v1
title: Cumulative PLOS ALM Report - February 2015

description: The PLOS ALM report contains the cumulative stats through February 2015.
DOI: 10.6084/m9.figshare.1367560.v1
title: he acquisition of complex number words in English and Chinese-speaking children

description: SRCD 2015 Poster
DOI: 10.6084/m9.figshare.1367560.v2
title: The acquisition of complex number words in English and Chinese-speaking children

description: SRCD 2015 Poster
DOI: 10.6084/m9.figshare.1367470
title: Implementation of the Pattern Branch and Bound algorithm for the Valued Workflow Satisfiability Problem

description: This file contains source codes of the Pattern Branch and Bound algorithm and a pseudo-random instance generator for the valued workflow satisfiability problem with user-independent constraints. This implementation was used in "Jason Crampton, Gregory Z. Gutin, and Daniel Karapetyan. Valued workflow satisfiability problem. In proc. of ACM symposium on Access control models and technologies (SACMAT), 1–3 June, Vienna, Austria. ACM, 2015." The algorithm and the generator are implemented in C#. The generator is deterministic; to produce distinct instances of the same size and properties, change the seed value. Provided are a Visual Studio 2013 project (including an example of generating an instance and solving it) and compiled x64 .NET executables. In addition, a class to solve the problem with CPLEX is included in the project. The MIP formulation of the problem can be found in the above paper. An installation of CPLEX is only required if this MIP based solver is used. The implementation of the algorithm and the generator is provided for non-commercial use only. When using this source code, please cite the above paper.
DOI: 10.6084/m9.figshare.1367457
title: DISEASES v1

description: These files constitute the last version of the DISEASES database to use STRING v9 protein identifiers.
DOI: 10.6084/m9.figshare.1367470.v1
title: Implementation of the Pattern Branch and Bound algorithm for the Valued Workflow Satisfiability Problem

description: This file contains source codes of the Pattern Branch and Bound algorithm and a pseudo-random instance generator for the valued workflow satisfiability problem with user-independent constraints. This implementation was used in "Jason Crampton, Gregory Z. Gutin, and Daniel Karapetyan. Valued workflow satisfiability problem. In proc. of ACM symposium on Access control models and technologies (SACMAT), 1–3 June, Vienna, Austria. ACM, 2015." The algorithm and the generator are implemented in C#. The generator is deterministic; to produce distinct instances of the same size and properties, change the seed value. Provided are a Visual Studio 2013 project (including an example of generating an instance and solving it) and compiled x64 .NET executables. In addition, a class to solve the problem with CPLEX is included in the project. The MIP formulation of the problem can be found in the above paper. An installation of CPLEX is only required if this MIP based solver is used. The implementation of the algorithm and the generator is provided for non-commercial use only. When using this source code, please cite the above paper.
DOI: 10.6084/m9.figshare.1367456
title: TISSUES v1

description: These files constitute the last version of the TISSUES database to use STRING v9 protein identifiers.
DOI: 10.6084/m9.figshare.1367450
title: COMPARTMENTS benchmark

description: These files constitute the benchmark set used for the COMPARTMENTS publication. All protein identifiers are consistent with STRING v9.
DOI: 10.6084/m9.figshare.1367453
title: COMPARTMENTS v1

description: These files constitute the last version of the COMPARTMENTS database to use STRING v9 protein identifiers.
DOI: 10.6084/m9.figshare.1367456.v1
title: TISSUES v1

description: These files constitute the last version of the TISSUES database to use STRING v9 protein identifiers.
DOI: 10.6084/m9.figshare.1367453.v1
title: COMPARTMENTS v1

description: These files constitute the last version of the COMPARTMENTS database to use STRING v9 protein identifiers.
DOI: 10.6084/m9.figshare.1367443
title: DISEASES v1 (human, text mining, filtered)

description: This file constitutes the filtered text-mining channel on human proteins for the last version of the DISEASES database to use STRING v9 protein identifiers.
DOI: 10.6084/m9.figshare.1367442
title: DISEASES v1 (human, text mining, full)

description: This file constitutes the full text-mining channel on human proteins for the last version of the DISEASES database to use STRING v9 protein identifiers.
DOI: 10.6084/m9.figshare.1367450.v1
title: COMPARTMENTS benchmark

description: These files constitute the benchmark set used for the COMPARTMENTS publication. All protein identifiers are consistent with STRING v9.
DOI: 10.6084/m9.figshare.1367441
title: DISEASES v1 (human, experiments, filtered)

description: This file constitutes the filtered experiments channel on human proteins for the last version of the DISEASES database to use STRING v9 protein identifiers.
DOI: 10.6084/m9.figshare.1367439
title: DISEASES v1 (human, knowledge, filtered)

description: This file constitutes the filtered knowledge channel on human proteins for the last version of the DISEASES database to use STRING v9 protein identifiers.
DOI: 10.6084/m9.figshare.1367440
title: DISEASES v1 (human, experiments, full)

description: This file constitutes the full experiments channel on human proteins for the last version of the DISEASES database to use STRING v9 protein identifiers.
DOI: 10.6084/m9.figshare.1367442.v1
title: DISEASES v1 (human, text mining, full)

description: This file constitutes the full text-mining channel on human proteins for the last version of the DISEASES database to use STRING v9 protein identifiers.
DOI: 10.6084/m9.figshare.1367440.v1
title: DISEASES v1 (human, experiments, full)

description: This file constitutes the full experiments channel on human proteins for the last version of the DISEASES database to use STRING v9 protein identifiers.
DOI: 10.6084/m9.figshare.1367437
title: TISSUES v1 (human, text mining, filtered)

description: This file constitutes the filtered text-mining channel on human proteins for the last version of the TISSUES database to use STRING v9 protein identifiers.
DOI: 10.6084/m9.figshare.1367438
title: DISEASES v1 (human, knowledge, full)

description: This file constitutes the full knowledge channel on human proteins for the last version of the DISEASES database to use STRING v9 protein identifiers.
DOI: 10.6084/m9.figshare.1367439.v1
title: DISEASES v1 (human, knowledge, filtered)

description: This file constitutes the filtered knowledge channel on human proteins for the last version of the DISEASES database to use STRING v9 protein identifiers.
DOI: 10.6084/m9.figshare.1367435
title: TISSUES v1 (human, experiments, filtered)

description: This file constitutes the filtered experiments channel on human proteins for the last version of the TISSUES database to use STRING v9 protein identifiers.
DOI: 10.6084/m9.figshare.1367435.v1
title: TISSUES v1 (human, experiments, filtered)

description: This file constitutes the filtered experiments channel on human proteins for the last version of the TISSUES database to use STRING v9 protein identifiers.
DOI: 10.6084/m9.figshare.1367436
title: TISSUES v1 (human, text mining, full)

description: This file constitutes the full text-mining channel on human proteins for the last version of the TISSUES database to use STRING v9 protein identifiers.
DOI: 10.6084/m9.figshare.1367437.v1
title: TISSUES v1 (human, text mining, filtered)

description: This file constitutes the filtered text-mining channel on human proteins for the last version of the TISSUES database to use STRING v9 protein identifiers.
DOI: 10.6084/m9.figshare.1367438.v1
title: DISEASES v1 (human, knowledge, full)

description: This file constitutes the full knowledge channel on human proteins for the last version of the DISEASES database to use STRING v9 protein identifiers.
DOI: 10.6084/m9.figshare.1367434
title: TISSUES v1 (human, experiments, full)

description: This file constitutes the full experiments channel on human proteins for the last version of the TISSUES database to use STRING v9 protein identifiers.
DOI: 10.6084/m9.figshare.1367436.v1
title: TISSUES v1 (human, text mining, full)

description: This file constitutes the full text-mining channel on human proteins for the last version of the TISSUES database to use STRING v9 protein identifiers.
DOI: 10.6084/m9.figshare.1367432
title: TISSUES v1 (human, knowledge, full)

description: This file constitutes the full knowledge channel on human proteins for the last version of the TISSUES database to use STRING v9 protein identifiers.
DOI: 10.6084/m9.figshare.1367433
title: TISSUES v1 (human, knowledge, filtered)

description: This file constitutes the filtered knowledge channel on human proteins for the last version of the TISSUES database to use STRING v9 protein identifiers.
DOI: 10.6084/m9.figshare.1367431
title: COMPARTMENTS v1 (arabidopsis, predictions)

description: This file constitutes the predictions channel on arabidopsis proteins for the last version of the COMPARTMENTS database to use STRING v9 protein identifiers.
DOI: 10.6084/m9.figshare.1367431.v1
title: COMPARTMENTS v1 (arabidopsis, predictions)

description: This file constitutes the predictions channel on arabidopsis proteins for the last version of the COMPARTMENTS database to use STRING v9 protein identifiers.
DOI: 10.6084/m9.figshare.1367433.v1
title: TISSUES v1 (human, knowledge, filtered)

description: This file constitutes the filtered knowledge channel on human proteins for the last version of the TISSUES database to use STRING v9 protein identifiers.
DOI: 10.6084/m9.figshare.1367434.v2
title: TISSUES v1 (human, experiments, full)

description: This file constitutes the full experiments channel on human proteins for the last version of the TISSUES database to use STRING v9 protein identifiers.
DOI: 10.6084/m9.figshare.1367429
title: COMPARTMENTS v1 (arabidopsis, knowledge)

description: This file constitutes the knowledge channel on arabidopsis proteins for the last version of the COMPARTMENTS database to use STRING v9 protein identifiers.
DOI: 10.6084/m9.figshare.1367430
title: COMPARTMENTS v1 (arabidopsis, text mining)

description: This file constitutes the text-mining channel on arabidopsis proteins for the last version of the COMPARTMENTS database to use STRING v9 protein identifiers.
DOI: 10.6084/m9.figshare.1367432.v2
title: TISSUES v1 (human, knowledge, full)

description: This file constitutes the full knowledge channel on human proteins for the last version of the TISSUES database to use STRING v9 protein identifiers.
DOI: 10.6084/m9.figshare.1367434.v1
title: TISSUES v1 (human, experiments)

description: This file constitutes the experiments channel on human proteins for the last version of the TISSUES database to use STRING v9 protein identifiers.
DOI: 10.6084/m9.figshare.1367429.v1
title: COMPARTMENTS v1 (arabidopsis, knowledge)

description: This file constitutes the knowledge channel on arabidopsis proteins for the last version of the COMPARTMENTS database to use STRING v9 protein identifiers.
DOI: 10.6084/m9.figshare.1367430.v1
title: COMPARTMENTS v1 (arabidopsis, text mining)

description: This file constitutes the text-mining channel on arabidopsis proteins for the last version of the COMPARTMENTS database to use STRING v9 protein identifiers.
DOI: 10.6084/m9.figshare.1367428
title: COMPARTMENTS v1 (yeast, predictions)

description: This file constitutes the predictions channel on yeast proteins for the last version of the COMPARTMENTS database to use STRING v9 protein identifiers.
DOI: 10.6084/m9.figshare.1367432.v1
title: TISSUES v1 (human, knowledge)

description: This file constitutes the knowledge channel on human proteins for the last version of the TISSUES database to use STRING v9 protein identifiers.
DOI: 10.6084/m9.figshare.1367426
title: COMPARTMENTS v1 (yeast, knowledge)

description: This file constitutes the knowledge channel on yeast proteins for the last version of the COMPARTMENTS database to use STRING v9 protein identifiers.
DOI: 10.6084/m9.figshare.1367427
title: COMPARTMENTS v1 (yeast, text mining)

description: This file constitutes the text-mining channel on yeast proteins for the last version of the COMPARTMENTS database to use STRING v9 protein identifiers.
DOI: 10.6084/m9.figshare.1367428.v1
title: COMPARTMENTS v1 (yeast, predictions)

description: This file constitutes the predictions channel on yeast proteins for the last version of the COMPARTMENTS database to use STRING v9 protein identifiers.
DOI: 10.6084/m9.figshare.1367424
title: COMPARTMENTS v1 (worm, text mining)

description: This file constitutes the text-mining channel on worm proteins for the last version of the COMPARTMENTS database to use STRING v9 protein identifiers.
DOI: 10.6084/m9.figshare.1367425
title: COMPARTMENTS v1 (worm, predictions)

description: This file constitutes the predictions channel on worm proteins for the last version of the COMPARTMENTS database to use STRING v9 protein identifiers.
DOI: 10.6084/m9.figshare.1367426.v1
title: COMPARTMENTS v1 (yeast, knowledge)

description: This file constitutes the knowledge channel on yeast proteins for the last version of the COMPARTMENTS database to use STRING v9 protein identifiers.
DOI: 10.6084/m9.figshare.1367427.v1
title: COMPARTMENTS v1 (yeast, text mining)

description: This file constitutes the text-mining channel on yeast proteins for the last version of the COMPARTMENTS database to use STRING v9 protein identifiers.
DOI: 10.6084/m9.figshare.1367422
title: COMPARTMENTS v1 (fly, predictions)

description: This file constitutes the predictions channel on fly proteins for the last version of the COMPARTMENTS database to use STRING v9 protein identifiers.
DOI: 10.6084/m9.figshare.1367422.v1
title: COMPARTMENTS v1 (fly, predictions)

description: This file constitutes the predictions channel on fly proteins for the last version of the COMPARTMENTS database to use STRING v9 protein identifiers.
DOI: 10.6084/m9.figshare.1367423
title: COMPARTMENTS v1 (worm, knowledge)

description: This file constitutes the knowledge channel on worm proteins for the last version of the COMPARTMENTS database to use STRING v9 protein identifiers.
DOI: 10.6084/m9.figshare.1367424.v1
title: COMPARTMENTS v1 (worm, text mining)

description: This file constitutes the text-mining channel on worm proteins for the last version of the COMPARTMENTS database to use STRING v9 protein identifiers.
DOI: 10.6084/m9.figshare.1367425.v1
title: COMPARTMENTS v1 (worm, predictions)

description: This file constitutes the predictions channel on worm proteins for the last version of the COMPARTMENTS database to use STRING v9 protein identifiers.
DOI: 10.6084/m9.figshare.1367419
title: COMPARTMENTS v1 (rat, predictions)

description: This file constitutes the predictions channel on rat proteins for the last version of the COMPARTMENTS database to use STRING v9 protein identifiers.
DOI: 10.6084/m9.figshare.1367420
title: COMPARTMENTS v1 (fly, knowledge)

description: This file constitutes the knowledge channel on fly proteins for the last version of the COMPARTMENTS database to use STRING v9 protein identifiers.
DOI: 10.6084/m9.figshare.1367421
title: COMPARTMENTS v1 (fly, text mining)

description: This file constitutes the text-mining channel on fly proteins for the last version of the COMPARTMENTS database to use STRING v9 protein identifiers.
DOI: 10.6084/m9.figshare.1367423.v1
title: COMPARTMENTS v1 (worm, knowledge)

description: This file constitutes the knowledge channel on worm proteins for the last version of the COMPARTMENTS database to use STRING v9 protein identifiers.
DOI: 10.6084/m9.figshare.1367418
title: COMPARTMENTS v1 (rat, text mining)

description: This file constitutes the text-mining channel on rat proteins for the last version of the COMPARTMENTS database to use STRING v9 protein identifiers.
DOI: 10.6084/m9.figshare.1367421.v1
title: COMPARTMENTS v1 (fly, text mining)

description: This file constitutes the text-mining channel on fly proteins for the last version of the COMPARTMENTS database to use STRING v9 protein identifiers.
DOI: 10.6084/m9.figshare.1367418.v1
title: COMPARTMENTS v1 (rat, text mining)

description: This file constitutes the text-mining channel on rat proteins for the last version of the COMPARTMENTS database to use STRING v9 protein identifiers.
DOI: 10.6084/m9.figshare.1367416
title: COMPARTMENTS v1 (mouse, predictions)

description: This file constitutes the predictions channel on mouse proteins for the last version of the COMPARTMENTS database to use STRING v9 protein identifiers.
DOI: 10.6084/m9.figshare.1367417
title: COMPARTMENTS v1 (rat, knowledge)

description: This file constitutes the knowledge channel on rat proteins for the last version of the COMPARTMENTS database to use STRING v9 protein identifiers.
DOI: 10.6084/m9.figshare.1367419.v1
title: COMPARTMENTS v1 (rat, predictions)

description: This file constitutes the predictions channel on rat proteins for the last version of the COMPARTMENTS database to use STRING v9 protein identifiers.
DOI: 10.6084/m9.figshare.1367414
title: COMPARTMENTS v1 (mouse, knowledge)

description: This file constitutes the knowledge channel on mouse proteins for the last version of the COMPARTMENTS database to use STRING v9 protein identifiers.
DOI: 10.6084/m9.figshare.1367415
title: COMPARTMENTS v1 (mouse, text mining)

description: This file constitutes the text-mining channel on mouse proteins for the last version of the COMPARTMENTS database to use STRING v9 protein identifiers.
DOI: 10.6084/m9.figshare.1367417.v1
title: COMPARTMENTS v1 (rat, knowledge)

description: This file constitutes the knowledge channel on rat proteins for the last version of the COMPARTMENTS database to use STRING v9 protein identifiers.
DOI: 10.6084/m9.figshare.1367415.v1
title: COMPARTMENTS v1 (mouse, text mining)

description: This file constitutes the text-mining channel on mouse proteins for the last version of the COMPARTMENTS database to use STRING v9 protein identifiers.
DOI: 10.6084/m9.figshare.1367416.v1
title: COMPARTMENTS v1 (mouse, predictions)

description: This file constitutes the predictions channel on mouse proteins for the last version of the COMPARTMENTS database to use STRING v9 protein identifiers.
DOI: 10.6084/m9.figshare.1367412
title: COMPARTMENTS v1 (human, text mining)

description: This file constitutes the text-mining channel on human proteins for the last version of the COMPARTMENTS database to use STRING v9 protein identifiers.
DOI: 10.6084/m9.figshare.1367414.v1
title: COMPARTMENTS v1 (mouse, knowledge)

description: This file constitutes the knowledge channel on mouse proteins for the last version of the COMPARTMENTS database to use STRING v9 protein identifiers.
DOI: 10.6084/m9.figshare.1367410
title: COMPARTMENTS v1 (human, experiments)

description: This file constitutes the experiments channel on human proteins for the last version of the COMPARTMENTS database to use STRING v9 protein identifiers.
DOI: 10.6084/m9.figshare.1367412.v1
title: COMPARTMENTS v1 (human, text mining)

description: This file constitutes the text-mining channel on human proteins for the last version of the COMPARTMENTS database to use STRING v9 protein identifiers.
DOI: 10.6084/m9.figshare.1367413
title: COMPARTMENTS v1 (human, predictions)

description: This file constitutes the predictions channel on human proteins for the last version of the COMPARTMENTS database to use STRING v9 protein identifiers.
DOI: 10.6084/m9.figshare.1367409
title: COMPARTMENTS v1 (human, knowledge)

description: This file constitutes the knowledge channel on human proteins for the last version of the COMPARTMENTS database to use STRING v9 protein identifiers.
DOI: 10.6084/m9.figshare.1367410.v1
title: COMPARTMENTS v1 (human, experiments)

description: This file constitutes the experiments channel on human proteins for the last version of the COMPARTMENTS database to use STRING v9 protein identifiers.
DOI: 10.6084/m9.figshare.1367408
title: COMPARTMENTS benchmark (yeast)

description: This file constitutes the yeast benchmark set used for the COMPARTMENTS publication. All protein identifiers are consistent with STRING v9.
DOI: 10.6084/m9.figshare.1367406
title: Passiflora ischnoclada distribution

description: These files are part of the results of a biogeographic research about the potential and real distribution of Passiflora ischnoclada Harms. We started with a single known occurrence point for the species, from where an environmental dissimilarity model was generated to guide new fieldwork. Other models were generated as more points were found, until a final consensus model was generated using 5 algorithms. This final model was used to estimate the real distribution of the species.
DOI: 10.6084/m9.figshare.1367407
title: COMPARTMENTS benchmark (human)

description: This file constitutes the human benchmark set used for the COMPARTMENTS publication. All protein identifiers are consistent with STRING v9.
DOI: 10.6084/m9.figshare.1367409.v1
title: COMPARTMENTS v1 (human, knowledge)

description: This file constitutes the knowledge channel on human proteins for the last version of the COMPARTMENTS database to use STRING v9 protein identifiers.