cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.24646326
title: Delineation of DNA and mRNA COVID-19 vaccine-induced immune responses in preclinical animal models

description: Nucleic acid vaccines are designed based on genetic sequences (DNA or mRNA) of a target antigen to be expressed <i>in vivo</i> to drive a host immune response. In response to the COVID-19 pandemic, mRNA and DNA vaccines based on the SARS-CoV-2 Spike antigen were developed. Surprisingly, head-to-head characterizations of the immune responses elicited by each vaccine type has not been performed to date. Here, we have employed a range of preclinical animal models including the hamster, guinea pig, rabbit, and mouse to compare and delineate the immune response raised by DNA, administered intradermally (ID) with electroporation (EP) and mRNA vaccines (BNT162b2 or mRNA-1273), administered intramuscularly (IM), expressing the SARS-CoV-2 WT spike antigen. The results revealed clear differences in the quality and magnitude of the immune response between the two vaccine platforms. The DNA vaccine immune response was characterized by strong T cell responses, while the mRNA vaccine elicited robust humoral responses. The results may assist in guiding the disease target each vaccine type may be best matched against and suggest mechanisms to further enhance the breadth of each platform’s immune response.
DOI: 10.6084/m9.figshare.24646326.v1
title: Delineation of DNA and mRNA COVID-19 vaccine-induced immune responses in preclinical animal models

description: Nucleic acid vaccines are designed based on genetic sequences (DNA or mRNA) of a target antigen to be expressed <i>in vivo</i> to drive a host immune response. In response to the COVID-19 pandemic, mRNA and DNA vaccines based on the SARS-CoV-2 Spike antigen were developed. Surprisingly, head-to-head characterizations of the immune responses elicited by each vaccine type has not been performed to date. Here, we have employed a range of preclinical animal models including the hamster, guinea pig, rabbit, and mouse to compare and delineate the immune response raised by DNA, administered intradermally (ID) with electroporation (EP) and mRNA vaccines (BNT162b2 or mRNA-1273), administered intramuscularly (IM), expressing the SARS-CoV-2 WT spike antigen. The results revealed clear differences in the quality and magnitude of the immune response between the two vaccine platforms. The DNA vaccine immune response was characterized by strong T cell responses, while the mRNA vaccine elicited robust humoral responses. The results may assist in guiding the disease target each vaccine type may be best matched against and suggest mechanisms to further enhance the breadth of each platform’s immune response.
DOI: 10.6084/m9.figshare.24873202.v1
title: Efficacy of different AV7909 dose regimens in a nonclinical model of pulmonary anthrax

description: Pulmonary anthrax caused by exposure to inhaled <i>Bacillus anthracis</i>, the most lethal form of anthrax disease, is a continued military and public health concern for the United States. The vaccine AV7909, consisting of the licensed anthrax drug substance AVA adjuvanted with CpG7909, induces high levels of toxin neutralizing antibodies in healthy adults using fewer doses than AVA. This study compares the ability of one- or two-dose regimens of AV7909 to induce a protective immune response in guinea pigs challenged with a lethal dose of aerosolized <i>B. anthracis</i> spores 6 weeks after the last vaccine dose. The results indicated that AV7909 was less effective when delivered as a single dose compared to the two-dose regimen that resulted in dose-dependent protection against death. The toxin neutralizing assay (TNA) titer and anti-PA IgG responses were proportional to the protective efficacy, with a 50% TNA neutralizing factor (NF<sub>50</sub>) greater than 0.1 associated with survival in animals receiving two doses of vaccine. The strong protection at relatively low TNA NF<sub>50</sub> titers in this guinea pig model supports the exploration of lower doses in clinical trials to determine if these protective levels of neutralizing antibodies can be achieved in humans; however, protection with a single dose may not be feasible.
DOI: 10.6084/m9.figshare.24873202
title: Efficacy of different AV7909 dose regimens in a nonclinical model of pulmonary anthrax

description: Pulmonary anthrax caused by exposure to inhaled <i>Bacillus anthracis</i>, the most lethal form of anthrax disease, is a continued military and public health concern for the United States. The vaccine AV7909, consisting of the licensed anthrax drug substance AVA adjuvanted with CpG7909, induces high levels of toxin neutralizing antibodies in healthy adults using fewer doses than AVA. This study compares the ability of one- or two-dose regimens of AV7909 to induce a protective immune response in guinea pigs challenged with a lethal dose of aerosolized <i>B. anthracis</i> spores 6 weeks after the last vaccine dose. The results indicated that AV7909 was less effective when delivered as a single dose compared to the two-dose regimen that resulted in dose-dependent protection against death. The toxin neutralizing assay (TNA) titer and anti-PA IgG responses were proportional to the protective efficacy, with a 50% TNA neutralizing factor (NF<sub>50</sub>) greater than 0.1 associated with survival in animals receiving two doses of vaccine. The strong protection at relatively low TNA NF<sub>50</sub> titers in this guinea pig model supports the exploration of lower doses in clinical trials to determine if these protective levels of neutralizing antibodies can be achieved in humans; however, protection with a single dose may not be feasible.
DOI: 10.6084/m9.figshare.24864217
title: Comparing factors influencing seasonal influenza vaccine acceptance and intentions among Chinese university students residing in China and UK: A cross-sectional study

description: University students, who face an elevated risk of influenza due to close living quarters and frequent social interactions, often exhibit low vaccine uptake rates. This issue is particularly pronounced among Chinese students, who encounter unique barriers related to awareness and access, emphasizing the need for heightened attention to this problem within this demographic. This cross-sectional study conducted in May-June 2022 involved 1,006 participants (404 in the UK, 602 in Mainland China) and aimed to explore and compare the factors influencing influenza vaccine acceptance and intentions between Chinese university students residing in the UK (C-UK) and Mainland China (C-M). The study employed a self-administered questionnaire based on the Theoretical Domains Framework and Capability Opportunity Motivation-Behavior model. Results revealed that approximately 46.8% of C-UK students received the influenza vaccine in the past year, compared to 32.9% of C-M students. More than half in both groups (C-UK: 54.5%, C-M: 58.1%) had no plans for vaccination in the upcoming year. Knowledge, belief about consequences, and reinforcement significantly influenced previous vaccine acceptance and intention in both student groups. Barriers to vaccination behavior included insufficient knowledge about the influenza vaccine and its accessibility and the distance to the vaccine center. Enablers included the vaccination behavior of individuals within their social circles, motivation to protect others, and concerns regarding difficulties in accessing medical resources during the COVID-19 pandemic. The findings of this study offer valuable insights for evidence-based intervention design, providing evidence for healthcare professionals, policymakers, and educators working to enhance vaccination rates within this specific demographic.
DOI: 10.6084/m9.figshare.24864217.v1
title: Comparing factors influencing seasonal influenza vaccine acceptance and intentions among Chinese university students residing in China and UK: A cross-sectional study

description: University students, who face an elevated risk of influenza due to close living quarters and frequent social interactions, often exhibit low vaccine uptake rates. This issue is particularly pronounced among Chinese students, who encounter unique barriers related to awareness and access, emphasizing the need for heightened attention to this problem within this demographic. This cross-sectional study conducted in May-June 2022 involved 1,006 participants (404 in the UK, 602 in Mainland China) and aimed to explore and compare the factors influencing influenza vaccine acceptance and intentions between Chinese university students residing in the UK (C-UK) and Mainland China (C-M). The study employed a self-administered questionnaire based on the Theoretical Domains Framework and Capability Opportunity Motivation-Behavior model. Results revealed that approximately 46.8% of C-UK students received the influenza vaccine in the past year, compared to 32.9% of C-M students. More than half in both groups (C-UK: 54.5%, C-M: 58.1%) had no plans for vaccination in the upcoming year. Knowledge, belief about consequences, and reinforcement significantly influenced previous vaccine acceptance and intention in both student groups. Barriers to vaccination behavior included insufficient knowledge about the influenza vaccine and its accessibility and the distance to the vaccine center. Enablers included the vaccination behavior of individuals within their social circles, motivation to protect others, and concerns regarding difficulties in accessing medical resources during the COVID-19 pandemic. The findings of this study offer valuable insights for evidence-based intervention design, providing evidence for healthcare professionals, policymakers, and educators working to enhance vaccination rates within this specific demographic.
DOI: 10.6084/m9.figshare.24865118
title: Evaluating the accessibility and capacity of SARS-CoV-2 vaccination and analyzing convenience-related factors during the Omicron variant epidemic in Beijing, China

description: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination service system lacks standardized indicators to assess resource allocation. Moreover, data on specific vaccination-promoting measures is limited. This study aimed to evaluate vaccination accessibility and capacity and investigate convenience-related factors in China during the Omicron variant epidemic. We collected information on SARS-CoV-2 vaccination services among vaccination sites in Beijing. Analysis was performed using nearest neighbor, Ripley’s K, hot spot analysis, and generalized estimating equations. Overall, 299 vaccination sites were included. The demand for the SARS-CoV-2 vaccine increased with the increase in daily new cases, and the number of staff administering vaccines should be increased in urban areas at the beginning of the epidemic. Providing vaccination for both children and adults, extending vaccination service hours, and offering a wider range of vaccine categories significantly increased the doses of vaccines administered (all <i>P</i> &lt; .05). The provision of mobile vaccination vehicles effectively increased the doses of vaccines administered to individuals aged ≥ 60 years (<i>P</i> &lt; .05). The allocation of SARS-CoV-2 vaccination services should be adjusted according to geographic location, population size, and vaccination demands. Simultaneous provision of vaccination services for children and their guardians, flexible service hours, prompt innovative vaccine production, and tailored vaccination strategies can foster vaccination uptake.
DOI: 10.15468/dl.yd5dxf
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Alectoris magna",
 "Country is Chinese Taipei",
 "HasCoordinate is true"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0050186-250811113504898/datasets/export for details.
DOI: 10.5258/soton/d3507
title: Dataset for publication "Wearable sensor system for monitoring atopic dermatitis in patients"

description: Dataset for a publication in print in IEEE Sensors Journal, named "Wearable Sensor System for Monitoring Atopic Dermatitis in Patients"
The dataset includes .csv files of all the data used to create the plots in the publication.
DOI: 10.3535/52f-r7b-ka9
title: Animalia

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/sxt-r46-ber
title: Bivalvia Linnaeus, 1758

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.15468/dl.tcqjpr
title: Occurrence Download

description: A dataset containing 10771 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Rhopilema nomadica",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "Geometry POLYGON ((-6.6 29.26705, -6.6 50.94, 40.81373 50.94, 40.81373 29.26705, -6.6 29.26705))",
 "BasisOfRecord is one of (Human Observation, Machine Observation, Observation, Material sample)"
 ]
}

 The dataset includes 10771 records from 9 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0000044-250827131500795/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.kxpj3w
title: Occurrence Download

description: A dataset containing 508 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Adelges tsugae",
 "Country is Canada",
 "HasCoordinate is true",
 "Year is greater than or equal to 2012"
 ]
}

 The dataset includes 508 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0001075-250827131500795/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.kdtvuk
title: Occurrence Download

description: A dataset containing 3094 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Syringa vulgaris",
 "Country is Russian Federation",
 "HasCoordinate is true"
 ]
}

 The dataset includes 3094 records from 41 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0001076-250827131500795/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.c7yyg8
title: Occurrence Download

description: A dataset containing 17 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Syringa vulgaris",
 "Country is Türkiye",
 "HasCoordinate is true"
 ]
}

 The dataset includes 17 records from 3 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0001077-250827131500795/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.thmsnb
title: Occurrence Download

description: A dataset containing 212226 species occurrences available in GBIF matching the query:
{
 "and" : [
 "ScientificName is Prunus serotina Ehrh.",
 "Year is greater than or equal to 1990",
 "Year is less than or equal to 2025",
 "HasCoordinate is true",
 {
 "not" : {
 "DatasetKey" : [
 "is Catalogue of Life"
 ]
 }
 }
 ]
}

 The dataset includes 212226 records from 604 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0001033-250827131500795/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.drpqxj
title: Occurrence Download

description: A dataset containing 911 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Syringa vulgaris",
 "Country is Ukraine",
 "HasCoordinate is true"
 ]
}

 The dataset includes 911 records from 53 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0001078-250827131500795/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.x8a3bb
title: Occurrence Download

description: A dataset containing 370 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Continent is one of (South America, North America)",
 "EarliestEpochOrLowestSeries is Pleistocene",
 "PublishingOrg is ff418020-1d67-11d9-8435-b8a03c50a862",
 "TaxonKey is Bovidae"
 ]
}

 The dataset includes 370 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0001080-250827131500795/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.cg7km2
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Haplochromis chrysogynaion)",
 "BasisOfRecord is one of (Specimen, Literature Occurrence, Human Observation, Observation)",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "Year is greater than or equal to 1991",
 "Year is less than or equal to 2025"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0001079-250827131500795/datasets/export for details.
DOI: 10.15468/dl.k3hwgu
title: Occurrence Download

description: A dataset containing 9027 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Cupressus macrocarpa"
 ]
}

 The dataset includes 9027 records from 375 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0001081-250827131500795/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.4js4ya
title: Occurrence Download

description: A dataset containing 849 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Luria lurida",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "Geometry POLYGON ((-6.6 29.26705, -6.6 50.94, 40.81373 50.94, 40.81373 29.26705, -6.6 29.26705))",
 "BasisOfRecord is one of (Human Observation, Machine Observation, Observation, Material sample)"
 ]
}

 The dataset includes 849 records from 14 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0001083-250827131500795/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.36s8cq
title: Occurrence Download

description: A dataset containing 14706 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Syringa vulgaris",
 "Country is United Kingdom of Great Britain and Northern Ireland",
 "HasCoordinate is true"
 ]
}

 The dataset includes 14706 records from 86 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0001084-250827131500795/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.stgkaa
title: Occurrence Download

description: A dataset containing 2031 species occurrences available in GBIF matching the query:
{
 "and" : [
 "BasisOfRecord is Human Observation",
 "Continent is North America",
 "Country is United States of America",
 "TaxonKey is Cupressus macrocarpa",
 "Year 2018-2025"
 ]
}

 The dataset includes 2031 records from 2 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0001087-250827131500795/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.uhbf9r
title: Occurrence Download

description: A dataset containing 9020 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Syringa vulgaris",
 "Country is United States of America",
 "HasCoordinate is true"
 ]
}

 The dataset includes 9020 records from 117 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0001085-250827131500795/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.87fny2
title: Occurrence Download

description: A dataset containing 19733 species occurrences available in GBIF matching the query:
{
 "DatasetKey" : [
 "is LSUMZ Herp Tissues"
 ]
}

 The dataset includes 19733 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0001086-250827131500795/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.gmv5vr
title: Occurrence Download

description: A dataset containing 90 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Boulengerella lateristriga)",
 "BasisOfRecord is one of (Specimen, Literature Occurrence, Human Observation, Observation)",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "Year is greater than or equal to 1991",
 "Year is less than or equal to 2025"
 ]
}

 The dataset includes 90 records from 16 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0001089-250827131500795/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.34740/kaggle/dsv/12871811
title: Ethereum Fraud Dataset by Activity
DOI: 10.15468/dl.am9z4f
title: Occurrence Download

description: A dataset containing 2159450 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Ranunculus psilostachys, Ranunculus repens, Ranunculus sardous, Ranunculus sceleratus, Raphanus raphanistrum, Raphanus sativus, Rapistrum rugosum, Rauvolfia caffra, Ravenala madagascariensis, Reseda alba, Reseda lutea, Reynoutria bohemica, Reynoutria japonica, Reynoutria sachalinensis, Rhamnus alaternus, Rhamnus cathartica, Rhamnus utilis, Rhaphidophora korthalsii, Rhaphiolepis indica, Rhaponticum repens)",
 "BasisOfRecord is one of (Machine Observation, Human Observation, Observation)",
 "HasCoordinate is true",
 "Year is greater than or equal to 1990"
 ]
}

 The dataset includes 2159450 records from 4107 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0001063-250827131500795/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.5281/zenodo.15512130
title: 2017-London-L1#1

description: University of Reading Urban Micromet Group  

Contact Zenodo.micromet@gmail.com

 2017 London L0 #1/#2/#3

2017 London -L1 #1

2017 London RAW

MUHD metadata
DOI: 10.5281/zenodo.15512131
title: 2017-London-L1#1

description: University of Reading Urban Micromet Group  

Contact Zenodo.micromet@gmail.com

 2017 London L0 #1/#2/#3

2017 London -L1 #1

2017 London RAW

MUHD metadata