cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.57745/mg6ihx
title: 33122004.pdf

description: :unav
DOI: 10.57745/mrdjcl
title: README.md

description: Fichier README suivant le modèle https://recherche.data.gouv.fr/fr/categorie/33/guide/modele-de-readme
DOI: 10.57745/nyfiyh
title: 63189002.pdf

description: :unav
DOI: 10.57745/oogebf
title: 33080002.pdf

description: :unav
DOI: 10.57745/szawq5
title: 97118002.pdf

description: :unav
DOI: 10.57745/vcvlfq
title: 26313003.pdf

description: :unav
DOI: 10.57745/vylxgp
title: 13103002.pdf

description: :unav
DOI: 10.57745/ycbvns
title: 39130003.pdf

description: :unav
DOI: 10.57745/ztrgot
title: 30258005.pdf

description: :unav
DOI: 10.15468/dl.th6dr8
title: Occurrence Download

description: A dataset containing 6210 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Icerya purchasi Maskell, 1879"
 ]
}

 The dataset includes 6210 records from 79 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0032808-250426092105405/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.34622/datarepositorium/efazev
title: Design and Development of Textile Structures for Injury Prevention in Patients with Epidermolysis Bullosa

description: Data from the PhD research in Textile Engineering: "Design of smart clothing for prevention of injuries in users with Epidermolysis Bullosa".
DOI: 10.15468/dl.y9afcs
title: Occurrence Download

description: A dataset containing 135 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Dypsis decaryi (Jum.) Beentje & J.Dransf.)",
 "BasisOfRecord is one of (Specimen, Human Observation, Observation, Living Specimen, Machine Observation, Literature Occurrence)",
 "HasCoordinate is true",
 "HasGeospatialIssue is false"
 ]
}

 The dataset includes 135 records from 28 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0032809-250426092105405/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15126/surreydata.901481
title: Dataset associated with manuscript titled "Wake Characteristics of Multiscale Buildings in a Turbulent Boundary Layer"

description: Abstract from the manuscript associated with this dataset:Urban forms characterised by multi-scale roughness can drastically modify the wind structure within cities affecting both pedestrian comfort and air quality at street level. For simplicity, most urban flow studies focus on cuboid buildings with a single length scale. We consider six forms to assess how additional length scales impact urban flow: two reference cuboid cases (standard and tall) that differ in aspect ratio (mean building height to width), plus two additional fractal iterations of each}. The six models have the same mean building width, height, and frontal area but their length scale characteristics differ. These are used in wind tunnel experiments within a deep turbulent boundary layer. The length scale differences are found to affect the drag force exerted by the buildings in a non-negligible way (up to 5% and 13% for standard and tall buildings, respectively). The added length scales also modify the wake lateral spread and intensity of the turbulence fluctuations, with the smaller length scales having the lower (higher) intensity of fluctuations in the near (far) wake. Additionally, the strength of the vortex shedding emanating from the buildings is reduced by introducing systematically smaller length scales. This work suggests that the omission of additional length scales can lead to inaccuracies in drag and wake recovery estimations. The reduction in the intensity of vortex shedding found with each fractal iteration could have engineering applications (e.g. reducing vibration).
DOI: 10.15468/dl.d9an7q
title: Occurrence Download

description: A dataset containing 368534 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Epialtus brasiliensis Dana, 1852, Ischnoplax pectinata (G.B.Sowerby II, 1840), Lithopoma phoebium (Röding, 1798), Calliostoma zizyphinum (Linnaeus, 1758), Agathistoma viridulum (Gmelin, 1791), Ischnochiton striolatus (Gray, 1828), Malacoctenus delalandii (Valenciennes, 1836), Onchidella celtica (Audouin & Milne-Edwards, 1832), Rhyssoplax olivacea (Spengler, 1797), Lottia subrugosa (d'Orbigny, 1841), Hippolyte obliquimanus Dana, 1852, Fissurella clenchi Pérez Farfante, 1943, Lipophrys trigloides (Valenciennes, 1836), Leptochiton algesirensis (Capellini, 1859), Palaemon northropi (Rankin, 1898), Palaemon longirostris H.Milne-Edwards, 1837, Thorogobius ephippiatus (Lowe, 1839), Liocarcinus navigator (Herbst, 1794), Apherusa jurinei (H.Milne Edwards, 1830), Gobius couchi Miller & El-Tawil, 1974, Apohyale prevostii (H.Milne Edwards, 1830), Haliotis australis Gmelin, 1791, Tegula aureotincta (Forbes, 1852), Lacuna vincta (Montagu, 1803), Haliotis iris Gmelin, 1791, Patella pellucida Linnaeus, 1758, Litopenaeus schmitti (Burkenroad, 1936), Menippe nodifrons Stimpson, 1859, Eulithidium affine (C.B.Adams, 1850), Echinolittorina lineolata (d'Orbigny, 1840), Eriphia verrucosa (Forskål, 1775), Fissurella rosea (Gmelin, 1791), Cerithium atratum (Born, 1778), Eriphia gonagra (Fabricius, 1781), Palaemon serratus (Pennant, 1777), Clibanarius vittatus (Bosc, 1802), Gobius paganellus Linnaeus, 1758, Nymphon gracile Leach, 1814, Diplodus sargus sargus, Pirimela denticulata (Montagu, 1808), Patella depressa Pennant, 1777, Aplysia dactylomela Rang, 1828, Astyris lunata (Say, 1826), Clibanarius antillensis Stimpson, 1859, Engina turbinella (Kiener, 1836), Columbella mercatoria (Linnaeus, 1758), Galathea strigosa (Linnaeus, 1760), Lepidochitona cinerea (Linnaeus, 1767), Symphodus melops (Linnaeus, 1758), Pagurus bernhardus (Linnaeus, 1758))",
 "HasCoordinate is true",
 "HasGeospatialIssue is false"
 ]
}

 The dataset includes 368534 records from 717 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0032795-250426092105405/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.f6j753
title: Occurrence Download

description: A dataset containing 5694 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Azolla filiculoides Lam.",
 "Country is United Kingdom of Great Britain and Northern Ireland",
 "Year is greater than or equal to 1500"
 ]
}

 The dataset includes 5694 records from 100 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0032811-250426092105405/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.4hl8yp
title: Occurrence Download

description: A dataset containing 32 species occurrences available in GBIF matching the query:
{
 "DatasetKey" : [
 "is (Table 1) Proportion of Toxoplasma gondii seropositive arctic foxes (Alopex lagopus) by age group and geographic area"
 ]
}

 The dataset includes 32 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0035882-181108115102211/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.dqc3yr
title: Occurrence Download

description: A dataset containing 469026278 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Geometry POLYGON((-165.48181 6.1622,37.36741 6.1622,37.36741 84.24923,-165.48181 84.24923,-165.48181 6.1622))",
 {
 "or" : [
 "Month is March",
 "Month is April",
 "Month is May",
 "Month is June",
 "Month is July",
 "Month is August"
 ]
 },
 "OccurrenceStatus is Present",
 "TaxonKey is Aves",
 "Year 1990-2019"
 ]
}

 The dataset includes 469026278 records from 2468 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0261898-200613084148143/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.vrpy2v
title: Occurrence Download

description: A dataset containing 1 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Bivalvia)",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "Year is greater than or equal to 1980",
 "OccurrenceStatus is Present",
 {
 "not" : {
 "BasisOfRecord" : [
 "is one of (Fossil, Living Specimen)"
 ]
 }
 },
 "Geometry POLYGON((-10 -40,0 -40,0 -30,-10 -30,-10 -40))"
 ]
}

 The dataset includes 1 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0023399-251009101135966/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.bxhr3m
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Caudofoveata)",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "Year is greater than or equal to 1980",
 "OccurrenceStatus is Present",
 {
 "not" : {
 "BasisOfRecord" : [
 "is one of (Fossil, Living Specimen)"
 ]
 }
 },
 "Geometry POLYGON((150 30,160 30,160 40,150 40,150 30))"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0023401-251009101135966/datasets/export for details.
DOI: 10.15468/dl.2sf3nr
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Psittaciformes)",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "Year is greater than or equal to 1980",
 "OccurrenceStatus is Present",
 {
 "not" : {
 "BasisOfRecord" : [
 "is one of (Fossil, Living Specimen)"
 ]
 }
 },
 "Geometry POLYGON((90 -50,100 -50,100 -40,90 -40,90 -50))"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0023400-251009101135966/datasets/export for details.
DOI: 10.15468/dl.br69dc
title: Occurrence Download

description: A dataset containing 5497 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Scapania nemorosa"
 ]
}

 The dataset includes 5497 records from 112 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0023403-251009101135966/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.y84tgr
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "ScientificName is one of (Geothlypis trichas)",
 "HasCoordinate is true"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0062283-210914110416597/datasets/export for details.
DOI: 10.15468/dl.ly0mkk
title: Occurrence Download

description: A dataset containing 32 species occurrences available in GBIF matching the query:
{
 "DatasetKey" : [
 "is (Table 1) Proportion of Toxoplasma gondii seropositive arctic foxes (Alopex lagopus) by age group and geographic area"
 ]
}

 The dataset includes 32 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0012660-181003121212138/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.v2tpq4
title: Occurrence Download

description: A dataset containing 2939 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Wigandia urens (Ruiz & Pav.) Kunth"
 ]
}

 The dataset includes 2939 records from 164 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0204093-200613084148143/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.qzng7n
title: Occurrence Download

description: A dataset containing 32 species occurrences available in GBIF matching the query:
{
 "DatasetKey" : [
 "is (Table 1) Proportion of Toxoplasma gondii seropositive arctic foxes (Alopex lagopus) by age group and geographic area"
 ]
}

 The dataset includes 32 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0014129-190320150433242/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.spdxam
title: Occurrence Download

description: A dataset containing 57925 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Recurvirostra novaehollandiae Vieillot, 1816)",
 "BasisOfRecord is one of (Specimen, Human Observation, Observation, Machine Observation)",
 "HasCoordinate is true",
 "HasGeospatialIssue is false"
 ]
}

 The dataset includes 57925 records from 50 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0013698-230224095556074/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.9fv4wk
title: Occurrence Download

description: A dataset containing 32 species occurrences available in GBIF matching the query:
{
 "DatasetKey" : [
 "is (Table 1) Proportion of Toxoplasma gondii seropositive arctic foxes (Alopex lagopus) by age group and geographic area"
 ]
}

 The dataset includes 32 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0014154-190320150433242/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.kgzhvk
title: Occurrence Download

description: A dataset containing 718257345 species occurrences available in GBIF matching the query:
{
 "and" : [
 {
 "or" : [
 "BasisOfRecord is Machine Observation",
 "BasisOfRecord is Observation",
 "BasisOfRecord is Human Observation"
 ]
 },
 {
 "or" : [
 "License is CC-BY 4.0",
 "License is CC0 1.0"
 ]
 }
 ]
}

 The dataset includes 718257345 records from 10242 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0045017-181108115102211/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.3535/gmh-qk0-ae1
title: †Onychocella piriformis (Goldfuss, 1826)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.15468/dl.6b7cge
title: Occurrence Download

description: A dataset containing 4 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Gelidium spinosum",
 "Country is Türkiye",
 "HasCoordinate is true"
 ]
}

 The dataset includes 4 records from 4 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0021664-250811113504898/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.3535/82d-ytb-wf9
title: †Beisselina Canu, 1913

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/lyl-k4l-wg2
title: Mammalia Linnaeus, 1758

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/4ge-e1f-zkz
title: Olcostephanus

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/wfs-kvs-ct1
title: Olcostephanus

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/72s-08n-c76
title: Thynnichthys

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/l55-hl7-6el
title: Olcostephanus

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/ym6-t2f-gnp
title: Animalia

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/4cc-2z3-lqr
title: Animalia

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/yxf-9jt-klt
title: Rodentia Bowdich, 1821

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/5xq-55b-zx9
title: Mammalia Linnaeus, 1758

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/vd7-2qa-jmq
title: Mammalia Linnaeus, 1758

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.15468/dl.84vc86
title: Occurrence Download

description: A dataset containing 3 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Annona squamosa",
 "Country is Equatorial Guinea",
 "HasCoordinate is true"
 ]
}

 The dataset includes 3 records from 2 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0021665-250811113504898/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.3535/8t8-f1e-rcj
title: †Beisselina variabilis (von Hagenow, 1851)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/ng1-sew-336
title: Mammalia Linnaeus, 1758

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/c26-fmf-32t
title: Callianassa Leach, 1814

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/hwx-5rk-6x8
title: †Rodighieroites cardulus Company, 1987

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.15468/dl.mgfkz2
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Annona squamosa",
 "Country is Micronesia (Federated States of)",
 "HasCoordinate is true"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0021666-250811113504898/datasets/export for details.
DOI: 10.3535/s6b-54w-17t
title: Joannites

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.5281/zenodo.16899811
title: SARS-CoV-2 Infektionen in Deutschland

description: Der vorliegende Datansatz enthält umfassende Informationen zu SARS-CoV-2-Infektionen in Deutschland, die gemäß dem Infektionsschutzgesetze (IfSG) von den Gesundheitsämtern an das Robert Koch-Institut (RKI) gemeldet wurden. Die Daten umfassen Informationen zur Anzahl der bestätigten Fälle, Todesfälle und Genesungen, aus denen sich weitere Kennzahlen im Zusammenhang mit der COVID-19-Pandemie ableiten lassen. Der Datensatz wird täglich aktualisiert und enthält detaillierte Informationen auf Landkreisebene, die nach verschiedenen Altersgruppen aufgeschlüsselt sind. Die Bereitstellung des Datensatzes soll dazu beitragen, das Verständnis der COVID-19-Pandemie in Deutschland zu verbessern und die Berichterstattung, Forschung und Analyse in diesem Bereich zu unterstützen.
DOI: 10.3535/21h-vdn-vnc
title: Animalia

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/yl0-j5c-zep
title: Halorites

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/g1j-bhe-fkq
title: Animalia

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/xbh-f2d-e6b
title: †Neocomites peregrinus (Rawson & Kemper, 1978)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/bt2-6z9-ncm
title: Geochelone

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/550-9qn-nfr
title: Olcostephanus

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/xlw-r6d-2h6
title: Neolissoceras

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.15468/dl.hjyha9
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Annona squamosa",
 "Country is Fiji",
 "HasCoordinate is true"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0021667-250811113504898/datasets/export for details.
DOI: 10.3535/g7g-t8h-hy2
title: Animalia

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/gkd-kh1-zyf
title: Animalia

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/aae-l80-g5t
title: Animalia

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/mpt-fm6-0pf
title: †Belemnitida

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/sc1-tbp-bbe
title: Mammalia Linnaeus, 1758

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/v6g-pb9-57e
title: Cervus Linnaeus, 1758

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/zn2-55s-qed
title: †Belemnitida

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/269-gjc-3z2
title: Mammalia Linnaeus, 1758

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/xlq-w90-m14
title: Duvalia

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/8rv-vtz-2z7
title: Pseudobelus

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/efy-hgq-feg
title: Mammalia Linnaeus, 1758

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/60p-5vk-n1j
title: †Belemnitida

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/smj-ye4-gnp
title: †Belemnitida

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/hdf-fb0-q3a
title: Mammalia Linnaeus, 1758

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/pf3-k59-a0x
title: Mammalia Linnaeus, 1758

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/zey-8pp-f1g
title: Mammalia Linnaeus, 1758

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.25934/pr00012656
title: A Phase I/II, Randomized, Safety and Ascending Dose Ranging Study of Intrathecal Idursulfase-IT Administered in Conjunction With Intravenous Elaprase in Pediatric Patients With Hunter Syndrome and Cognitive Impairment

description: Elaprase (idursulfase), a large molecular protein, is not expected to cross the blood brain barrier at therapeutic levels when administered intravenously. A new formulation of idursulfase, idursulfase-IT, that differs from that of the intravenous (IV) formulation, Elaprase, has been developed to be suitable for delivery into the cerebrospinal fluid (CSF) via intrathecal administration.This Phase I/II study is designed to obtain necessary safety and exposure data, as well as secondary and exploratory outcome measures, to be interpreted and used in the design of subsequent clinical trials.