cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.20131579
title: Cellular consequences of small supernumerary marker chromosome derived from chromosome 12: mosaicism in daughter and father

description: Constitutional genomic imbalances are known to cause malformations, disabilities, neurodevelopmental delay, and dysmorphia and can lead to dysfunctions in the cell cycle. In extremely rare genetic conditions such as small supernumerary marker chromosomes (sSMC), it is important to understand the cellular consequences of this extra marker, as well the factors that contribute to their maintenance or elimination through successive cell cycles and phenotypic impact. The study of chromosomal mosaicism provides a natural model to characterize the effect of aneuploidy on genome stability and compare cells with the same genetic background and environment exposure, but differing in the presence of sSMC. Here, we report the functional characterization of different cell lines from two familial patients with mosaic sSMC derived from chromosome 12. We performed studies of proliferation dynamics, stability, and variability of these cells using fluorescent in situ hybridization (FISH), sister chromatid exchanges (SCE), and conventional staining. We also quantified the telomere-related genomic instability of sSMC cells using 3D telomeric profile analysis by quantitative-FISH. sSMC cells exhibited differences in the cell cycle dynamics compared to normal cells. First, the sSMC cells exhibited lower proliferation index and higher frequency of SCE than normal cells, associated with a higher level of chromosomal instability. Second, sSMC cells exhibited more telomeric-related genomic instability. Lastly, the differences of sSMC cells distribution among tissues could explain different phenotypic repercussions observed in patients. These results will help in our understanding of the sSMC stability, maintenance during cell cycle, and the cell cycle variables involved in the different phenotypic manifestations.
DOI: 10.6084/m9.figshare.20131579.v1
title: Cellular consequences of small supernumerary marker chromosome derived from chromosome 12: mosaicism in daughter and father

description: Constitutional genomic imbalances are known to cause malformations, disabilities, neurodevelopmental delay, and dysmorphia and can lead to dysfunctions in the cell cycle. In extremely rare genetic conditions such as small supernumerary marker chromosomes (sSMC), it is important to understand the cellular consequences of this extra marker, as well the factors that contribute to their maintenance or elimination through successive cell cycles and phenotypic impact. The study of chromosomal mosaicism provides a natural model to characterize the effect of aneuploidy on genome stability and compare cells with the same genetic background and environment exposure, but differing in the presence of sSMC. Here, we report the functional characterization of different cell lines from two familial patients with mosaic sSMC derived from chromosome 12. We performed studies of proliferation dynamics, stability, and variability of these cells using fluorescent in situ hybridization (FISH), sister chromatid exchanges (SCE), and conventional staining. We also quantified the telomere-related genomic instability of sSMC cells using 3D telomeric profile analysis by quantitative-FISH. sSMC cells exhibited differences in the cell cycle dynamics compared to normal cells. First, the sSMC cells exhibited lower proliferation index and higher frequency of SCE than normal cells, associated with a higher level of chromosomal instability. Second, sSMC cells exhibited more telomeric-related genomic instability. Lastly, the differences of sSMC cells distribution among tissues could explain different phenotypic repercussions observed in patients. These results will help in our understanding of the sSMC stability, maintenance during cell cycle, and the cell cycle variables involved in the different phenotypic manifestations.
DOI: 10.6084/m9.figshare.20131580
title: Building maintenance with emphasis in plumbing systems: a systematic review of the literature

description: ABSTRACT With the increasing demand for buildings, it is necessary that conservation and maintenance practices of building systems be properly specified and fulfilled. This research is a systematic review of the literature about the importance, consequences, and performance of plumbing systems. The search for articles was carried out on the Portal de Periódicos Capes covering the period from 2007 to 2017. 252 articles were found, but, based on the topic, just 26 were selected. The content of the articles was discussed in five research questions, including failures in plumbing systems, building maintenance, and assessment tools for plumbing performance and susceptibility to risks. It was observed that the failures in plumbing systems are common, mainly problems with leaks, which result in financial, time, and emotional costs for users. In addition, many of these pathological manifestations are related to the absence or failure of maintenance. However, maintenance is greatly influenced by factors such as material type, costs, and user expectations, requiring efficient maintenance programs and qualified teams to ensure the performance of the building and its systems. In addition, some tools have been developed in order to assess the building systems performance and susceptibility to risks, helping in the decision-making of maintenance and design phase.
DOI: 10.6084/m9.figshare.20131580.v1
title: Building maintenance with emphasis in plumbing systems: a systematic review of the literature

description: ABSTRACT With the increasing demand for buildings, it is necessary that conservation and maintenance practices of building systems be properly specified and fulfilled. This research is a systematic review of the literature about the importance, consequences, and performance of plumbing systems. The search for articles was carried out on the Portal de Periódicos Capes covering the period from 2007 to 2017. 252 articles were found, but, based on the topic, just 26 were selected. The content of the articles was discussed in five research questions, including failures in plumbing systems, building maintenance, and assessment tools for plumbing performance and susceptibility to risks. It was observed that the failures in plumbing systems are common, mainly problems with leaks, which result in financial, time, and emotional costs for users. In addition, many of these pathological manifestations are related to the absence or failure of maintenance. However, maintenance is greatly influenced by factors such as material type, costs, and user expectations, requiring efficient maintenance programs and qualified teams to ensure the performance of the building and its systems. In addition, some tools have been developed in order to assess the building systems performance and susceptibility to risks, helping in the decision-making of maintenance and design phase.
DOI: 10.6084/m9.figshare.20131582
title: Consumption inductors of displacement modes linked to ride-hailing in Brazil

description: Abstract The study proposed to survey the consumption inducers related to displacement on demand in Brazil and had 3425 interviews whose data were submitted to exploratory and confirmatory factor analysis using the IBM SPSS Statistics software. In order to have robustness in the results measured, the analysis variables relating to the country's reality were designed through a review of the state of the art and the design of the supply incidence points. Six variables underlying the consumption decision-making process, based on the technological aspect of supply and marked by the utilitarian sense of use, emerged from the research. As theoretical-practical implications, the results corroborate international research linking consumption to the aspect of personal interest to the detriment of the common good and socio-environmental concerns pointed out by the first studies related to the theme. In this way, advances in the field of knowledge are indicated by highlighting the impacts of convenience, technology and individualism in consumption. The study is innovative because it outlines the indicators of consumption direction, indicating trends to be observed by public managers and private organizations, in contrast to studies on the same theme whose observation base is restricted to one location or even region.
DOI: 10.6084/m9.figshare.20131582.v1
title: Consumption inductors of displacement modes linked to ride-hailing in Brazil

description: Abstract The study proposed to survey the consumption inducers related to displacement on demand in Brazil and had 3425 interviews whose data were submitted to exploratory and confirmatory factor analysis using the IBM SPSS Statistics software. In order to have robustness in the results measured, the analysis variables relating to the country's reality were designed through a review of the state of the art and the design of the supply incidence points. Six variables underlying the consumption decision-making process, based on the technological aspect of supply and marked by the utilitarian sense of use, emerged from the research. As theoretical-practical implications, the results corroborate international research linking consumption to the aspect of personal interest to the detriment of the common good and socio-environmental concerns pointed out by the first studies related to the theme. In this way, advances in the field of knowledge are indicated by highlighting the impacts of convenience, technology and individualism in consumption. The study is innovative because it outlines the indicators of consumption direction, indicating trends to be observed by public managers and private organizations, in contrast to studies on the same theme whose observation base is restricted to one location or even region.
DOI: 10.6084/m9.figshare.20131583
title: THE IMPACT OF SEXUALITY WORKSHOPS: A REPORT ON THE EXPERIENCES WITH THE STUDENTS

description: ABSTRACT The space for discussing sexuality in schools is limited, even with the perspective of preventing Sexually Transmitted Infections (STIs). On demand from a high school, students linked to the Tutorial Education Program of the Psychology course and the STI/AIDS Prevention Pole Extension Project held workshops with adolescents. The objective of this project was to dialogue about sexuality and promote discussions for the prevention of STIs through 9 workshops, with the participation of 18 students. These workshops were evaluated using two questionnaires and the data were treated in three axes: Workshop Evaluation - Methodologies and Facilitators; Assessing Adolescents as Multipliers and Assessing the Theme Importance for Adolescents. It was concluded that the workshops provided a means to promote STI prevention behaviors, to encourage the responsible exercise of sexuality and enabled the formation of bonds between facilitators and adolescents.
DOI: 10.6084/m9.figshare.20131583.v1
title: THE IMPACT OF SEXUALITY WORKSHOPS: A REPORT ON THE EXPERIENCES WITH THE STUDENTS

description: ABSTRACT The space for discussing sexuality in schools is limited, even with the perspective of preventing Sexually Transmitted Infections (STIs). On demand from a high school, students linked to the Tutorial Education Program of the Psychology course and the STI/AIDS Prevention Pole Extension Project held workshops with adolescents. The objective of this project was to dialogue about sexuality and promote discussions for the prevention of STIs through 9 workshops, with the participation of 18 students. These workshops were evaluated using two questionnaires and the data were treated in three axes: Workshop Evaluation - Methodologies and Facilitators; Assessing Adolescents as Multipliers and Assessing the Theme Importance for Adolescents. It was concluded that the workshops provided a means to promote STI prevention behaviors, to encourage the responsible exercise of sexuality and enabled the formation of bonds between facilitators and adolescents.
DOI: 10.6084/m9.figshare.20131585
title: Effects of Exercise Training on Left Ventricular Diastolic Function Markers in Patients with Obstructive Sleep Apnea: A Randomized Study

description: Abstract Background Exercise training (ET) is an adjunctive treatment for obstructive sleep apnea (OSA) and its consequences. However, the effects of exercise on heart remodeling are unknown in the population with OSA. Objective We investigated the effect of ET on markers of diastolic function, sleep parameters, and functional capacity in patients with OSA. Methods Sedentary patients with OSA (apnea-hypopnea index, AHI ≥15 events/hr) were randomly assigned to untrained (n=18) and trained (n=20) strategies. Polysomnography, cardiopulmonary exercise test, and echocardiography were evaluated at the beginning and end of the study. ET consisted of 3 weekly sessions of aerobic exercise, resistance exercises, and flexibility training (72 sessions, completed in 11.65±0.86 months). A two-way analysis of variance (ANOVA) was used, followed by Tukey's post-hoc test. The level of statistical significance was set at p&lt;0.05 for all analyses. Result Thirty-eight patients were included (AHI:45±29 events/hr, age:52±7 y, body mass index: 30±4 kg/m2). They had similar baseline parameters. ET caused a significant change in OSA severity (AHI:4.5±18 versus -5.7±13 events/hr; arousal index:1.5±8 versus -6.1±13 events/hr, in untrained and trained groups respectively, p&lt;0.05). The trained patients had an increase in functional capacity after intervention. ET improved isovolumetric relaxation time (IVRT, untrained=6.5±17.3 versus trained=-5.1±17.1 msec, p&lt;0.05). There was a significant correlation between changes in IVRT and arousal index in the trained group (r =-0.54, p&lt;0.05). No difference occurred in the other diastolic function parameters evaluated. Conclusion ET promotes modest but significant improvement in AHI, functional capacity, and cardiac IVRT, a validated parameter of diastolic function.
DOI: 10.6084/m9.figshare.20131585.v1
title: Effects of Exercise Training on Left Ventricular Diastolic Function Markers in Patients with Obstructive Sleep Apnea: A Randomized Study

description: Abstract Background Exercise training (ET) is an adjunctive treatment for obstructive sleep apnea (OSA) and its consequences. However, the effects of exercise on heart remodeling are unknown in the population with OSA. Objective We investigated the effect of ET on markers of diastolic function, sleep parameters, and functional capacity in patients with OSA. Methods Sedentary patients with OSA (apnea-hypopnea index, AHI ≥15 events/hr) were randomly assigned to untrained (n=18) and trained (n=20) strategies. Polysomnography, cardiopulmonary exercise test, and echocardiography were evaluated at the beginning and end of the study. ET consisted of 3 weekly sessions of aerobic exercise, resistance exercises, and flexibility training (72 sessions, completed in 11.65±0.86 months). A two-way analysis of variance (ANOVA) was used, followed by Tukey's post-hoc test. The level of statistical significance was set at p&lt;0.05 for all analyses. Result Thirty-eight patients were included (AHI:45±29 events/hr, age:52±7 y, body mass index: 30±4 kg/m2). They had similar baseline parameters. ET caused a significant change in OSA severity (AHI:4.5±18 versus -5.7±13 events/hr; arousal index:1.5±8 versus -6.1±13 events/hr, in untrained and trained groups respectively, p&lt;0.05). The trained patients had an increase in functional capacity after intervention. ET improved isovolumetric relaxation time (IVRT, untrained=6.5±17.3 versus trained=-5.1±17.1 msec, p&lt;0.05). There was a significant correlation between changes in IVRT and arousal index in the trained group (r =-0.54, p&lt;0.05). No difference occurred in the other diastolic function parameters evaluated. Conclusion ET promotes modest but significant improvement in AHI, functional capacity, and cardiac IVRT, a validated parameter of diastolic function.
DOI: 10.6084/m9.figshare.20131588.v1
title: The medium-term agenda in Brazil and the future of Petrobrás

description: Abstract This paper discusses the possible privatization of Petrobrás. It is argued that, despite the economic reasons that recommend its sale, probably the prerequisites for it will not exist in the short term. The purpose of the paper is to contribute to the discussion of this proposal, through the organization of the arguments related to the privatization - the “YPF model”. The alternative is the “PDVSA model”, opening up the oil sector, with Petrobrás remaining a State-owned company. Finally, some issues for reflection are suggested and some data associated with the company’s actual value are presented.
DOI: 10.6084/m9.figshare.20131588
title: The medium-term agenda in Brazil and the future of Petrobrás

description: Abstract This paper discusses the possible privatization of Petrobrás. It is argued that, despite the economic reasons that recommend its sale, probably the prerequisites for it will not exist in the short term. The purpose of the paper is to contribute to the discussion of this proposal, through the organization of the arguments related to the privatization - the “YPF model”. The alternative is the “PDVSA model”, opening up the oil sector, with Petrobrás remaining a State-owned company. Finally, some issues for reflection are suggested and some data associated with the company’s actual value are presented.
DOI: 10.6084/m9.figshare.20131589
title: Patterns of specialization, technological hiatus and foreign-exchange constrained growth

description: Abstract This paper presents a North-South model on the interaction between foreign trade and foreign-exchange constrained growth, a model in which patterns of specialization associated to production structures of the economies play a crucial role. Economic growth is conditioned by sector dynamics of innovation and imitation, as well as by income-elasticities and price-elasticities.
DOI: 10.6084/m9.figshare.20131589.v1
title: Patterns of specialization, technological hiatus and foreign-exchange constrained growth

description: Abstract This paper presents a North-South model on the interaction between foreign trade and foreign-exchange constrained growth, a model in which patterns of specialization associated to production structures of the economies play a crucial role. Economic growth is conditioned by sector dynamics of innovation and imitation, as well as by income-elasticities and price-elasticities.
DOI: 10.6084/m9.figshare.20131591
title: Acceptance of Low-Sodium Hospital Diet by Cardiac Patients: A Randomized Controlled Crossover Trial

description: Abstract Background Cardiovascular diseases are the major cause of hospitalization. Dietary salt restriction is indicated as part of clinical treatment, however, it is not always well accepted by the patients, resulting in low food intake and malnutrition. Objective To compare acceptance of a low-sodium diet cooked with salt with a standard low-sodium diet in cardiac inpatients. Methods A randomized controlled crossover trial in patients with low-sodium diet prescriptions (Clinical Trials NCT03481322). Patients were given a control standard low sodium diet (cooked without salt; salt [2g per meal] added by the patient at the time of consumption) on one day and on the next day patients were given the intervention diet – a low sodium diet cooked with salt (2 grams of salt, divided between preparations). Dietary acceptance was evaluated by weighing leftover food and calculating intake. A questionnaire was used to verify reasons that influenced acceptance. For data analysis, parametric data are presented as mean and standard deviation, Student’s t test was used to compare means, with significance defined as p&lt;0.05. Results Sixty-four patients were evaluated, with a mean age of 66 ± 11.3 years; 64% were male. There were no differences in percentage acceptance between the standard low-sodium diet and the low-sodium diet cooked with salt at lunch (p= 0.876) or at dinner (p= 0.255). Around 80% of what was offered at each meal was consumed by the patients, with no significant difference between groups. Conclusions The low-sodium diet cooked with salt was well accepted, but there was no difference when compared with the standard low-sodium diet, which also had adequate acceptance.
DOI: 10.6084/m9.figshare.20131591.v1
title: Acceptance of Low-Sodium Hospital Diet by Cardiac Patients: A Randomized Controlled Crossover Trial

description: Abstract Background Cardiovascular diseases are the major cause of hospitalization. Dietary salt restriction is indicated as part of clinical treatment, however, it is not always well accepted by the patients, resulting in low food intake and malnutrition. Objective To compare acceptance of a low-sodium diet cooked with salt with a standard low-sodium diet in cardiac inpatients. Methods A randomized controlled crossover trial in patients with low-sodium diet prescriptions (Clinical Trials NCT03481322). Patients were given a control standard low sodium diet (cooked without salt; salt [2g per meal] added by the patient at the time of consumption) on one day and on the next day patients were given the intervention diet – a low sodium diet cooked with salt (2 grams of salt, divided between preparations). Dietary acceptance was evaluated by weighing leftover food and calculating intake. A questionnaire was used to verify reasons that influenced acceptance. For data analysis, parametric data are presented as mean and standard deviation, Student’s t test was used to compare means, with significance defined as p&lt;0.05. Results Sixty-four patients were evaluated, with a mean age of 66 ± 11.3 years; 64% were male. There were no differences in percentage acceptance between the standard low-sodium diet and the low-sodium diet cooked with salt at lunch (p= 0.876) or at dinner (p= 0.255). Around 80% of what was offered at each meal was consumed by the patients, with no significant difference between groups. Conclusions The low-sodium diet cooked with salt was well accepted, but there was no difference when compared with the standard low-sodium diet, which also had adequate acceptance.
DOI: 10.6084/m9.figshare.20131592
title: Production costs and land appraisal: A case study of Polatlı, Turkey

description: ABSTRACT: In this study, the share of land rent in the fixed costs of wheat production was examined, and the aim of the study was to find land values using cost tables. To this purpose, we showed the effect of these on land values from the difference between field rents and net income. The study covered the district of Polatlı in Ankara province. Data on wheat production in Polatlı in 2017 was collected from six villages and 37 farms by means of a questionnaire. In selecting the farms, the ability to determine the land rent was taken into account as a selection criterion. The farms examined used on average per hectare, 11.9 hours of labor, 7.7 hours of draft power, 354.3 kg of fertilizer, 205.5 kg of seed, and 1.5 liters of agricultural chemicals. The average wheat production cost per hectare was $865.42; the average unit production cost was $0.23, and the production value was reported to be $1012.40/da. In this study, the land rent was of $225.40, and the net income from the land was reported to be $372.42. It was reported an evaluation performed using the taxation tables that land values according to rental incomes were $4508.80/ha, and $7448.40 when the land was worked by the landowner. Land rent constituted 26.05% of total production costs, and were equivalent to 22.26% of production value. When crop prices increased by 1%, income from the land increased by 4.49%.