cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.5281/zenodo.4059721
title: Coronary artery mechanics induces human saphenous vein remodelling via recruitment of adventitial myofibroblast-like cells mediated by Thrombospondin-1

description: This record contains raw data related to the article "Coronary artery mechanics induces human saphenous vein remodelling via recruitment of adventitial myofibroblast-like cells mediated by Thrombospondin-1". <strong>Rationale</strong>: Despite the preferred application of arterial conduits, the greater saphenous vein (SV) remains indispensable for coronary bypass grafting (CABG), especially in multi-vessel coronary artery disease (CAD). The objective of the present work was to address the role of mechanical forces in the activation of maladaptive vein bypass remodeling, a process determining progressive occlusion and recurrence of ischemic heart disease. <strong>Methods</strong>: We employed a custom bioreactor to mimic the coronary shear and wall mechanics in human SV vascular conduits and reproduce experimentally the biomechanical conditions of coronary grafting and analyzed vein remodeling process by histology, histochemistry and immunofluorescence. We also subjected vein-derived cells to cyclic uniaxial mechanical stimulation in culture, followed by phenotypic and molecular characterization using RNA and proteomic methods. We finally validated our results <em>in vitro</em> and using a model of SV carotid interposition in pigs. <strong>Results</strong>: Exposure to pulsatile flow determined a remodeling process of the vascular wall involving reduction in media thickness. Smooth muscle cells (SMCs) underwent conversion from contractile to synthetic phenotype. A time-dependent increase in proliferating cells expressing mesenchymal (CD44) and early SMC (SM22α) markers, apparently recruited from the SV adventitia, was observed especially in CABG-stimulated vessels. Mechanically stimulated SMCs underwent transition from contractile to synthetic phenotype. MALDI-TOF-based secretome analysis revealed a consistent release of Thrombospondin-1 (TSP-1), a matricellular protein involved in TGF-β-dependent signaling. TSP-1 had a direct chemotactic effect on SV adventitia resident progenitors (SVPs); this effects was inhibited by blocking TSP-1 receptor CD47. The involvement of TSP-1 in adventitial progenitor cells differentiation and graft intima hyperplasia was finally contextualized in the TGF-β-dependent pathway, and validated in a saphenous vein into carotid interposition pig model. <strong>Conclusions</strong>: Our results provide the evidence of a matricellular mechanism involved in the human vein arterialization process controlled by alterations in tissue mechanics, and open the way to novel potential strategies to block VGD progression based on targeting cell mechanosensing-related effectors.
DOI: 10.5281/zenodo.4059720
title: Coronary artery mechanics induces human saphenous vein remodelling via recruitment of adventitial myofibroblast-like cells mediated by Thrombospondin-1

description: This record contains raw data related to the article "Coronary artery mechanics induces human saphenous vein remodelling via recruitment of adventitial myofibroblast-like cells mediated by Thrombospondin-1". <strong>Rationale</strong>: Despite the preferred application of arterial conduits, the greater saphenous vein (SV) remains indispensable for coronary bypass grafting (CABG), especially in multi-vessel coronary artery disease (CAD). The objective of the present work was to address the role of mechanical forces in the activation of maladaptive vein bypass remodeling, a process determining progressive occlusion and recurrence of ischemic heart disease. <strong>Methods</strong>: We employed a custom bioreactor to mimic the coronary shear and wall mechanics in human SV vascular conduits and reproduce experimentally the biomechanical conditions of coronary grafting and analyzed vein remodeling process by histology, histochemistry and immunofluorescence. We also subjected vein-derived cells to cyclic uniaxial mechanical stimulation in culture, followed by phenotypic and molecular characterization using RNA and proteomic methods. We finally validated our results <em>in vitro</em> and using a model of SV carotid interposition in pigs. <strong>Results</strong>: Exposure to pulsatile flow determined a remodeling process of the vascular wall involving reduction in media thickness. Smooth muscle cells (SMCs) underwent conversion from contractile to synthetic phenotype. A time-dependent increase in proliferating cells expressing mesenchymal (CD44) and early SMC (SM22α) markers, apparently recruited from the SV adventitia, was observed especially in CABG-stimulated vessels. Mechanically stimulated SMCs underwent transition from contractile to synthetic phenotype. MALDI-TOF-based secretome analysis revealed a consistent release of Thrombospondin-1 (TSP-1), a matricellular protein involved in TGF-β-dependent signaling. TSP-1 had a direct chemotactic effect on SV adventitia resident progenitors (SVPs); this effects was inhibited by blocking TSP-1 receptor CD47. The involvement of TSP-1 in adventitial progenitor cells differentiation and graft intima hyperplasia was finally contextualized in the TGF-β-dependent pathway, and validated in a saphenous vein into carotid interposition pig model. <strong>Conclusions</strong>: Our results provide the evidence of a matricellular mechanism involved in the human vein arterialization process controlled by alterations in tissue mechanics, and open the way to novel potential strategies to block VGD progression based on targeting cell mechanosensing-related effectors.
DOI: 10.5281/zenodo.4120185
title: Validation of ESA CCI SM combined v04.7 vs ESA CCI SM combined v05.2 vs ISMN 20191211 global

description: QA4SM validation of soil moisture data: ESA CCI SM combined v04.7 vs ESA CCI SM combined v05.2 vs ISMN 20191211 global. URL: https://qa4sm.eu/result/ccfcee99-1d2a-4ee6-9919-8a3d87601d0b/. Produced on QA4SM (https://qa4sm.eu)
DOI: 10.5281/zenodo.4120184
title: Validation of ESA CCI SM combined v04.7 vs ESA CCI SM combined v05.2 vs ISMN 20191211 global

description: QA4SM validation of soil moisture data: ESA CCI SM combined v04.7 vs ESA CCI SM combined v05.2 vs ISMN 20191211 global. URL: https://qa4sm.eu/result/ccfcee99-1d2a-4ee6-9919-8a3d87601d0b/. Produced on QA4SM (https://qa4sm.eu)
DOI: 10.5281/zenodo.4120205
title: Validation of ESA CCI SM combined v04.7 vs ESA CCI SM combined v05.2 vs ISMN 20191211 global

description: QA4SM validation of soil moisture data: ESA CCI SM combined v04.7 vs ESA CCI SM combined v05.2 vs ISMN 20191211 global. URL: https://qa4sm.eu/result/0e820fbe-9bcb-47a2-8c7d-7f31f78b97c1/. Produced on QA4SM (https://qa4sm.eu)
DOI: 10.5281/zenodo.4120204
title: Validation of ESA CCI SM combined v04.7 vs ESA CCI SM combined v05.2 vs ISMN 20191211 global

description: QA4SM validation of soil moisture data: ESA CCI SM combined v04.7 vs ESA CCI SM combined v05.2 vs ISMN 20191211 global. URL: https://qa4sm.eu/result/0e820fbe-9bcb-47a2-8c7d-7f31f78b97c1/. Produced on QA4SM (https://qa4sm.eu)
DOI: 10.5517/ccdc.csd.cc24lz3v
title: CCDC 1984437: Experimental Crystal Structure Determination

description: Related Article: Wenjing Li, Juan Tang, Shun Li, Xueli Zheng, Maolin Yuan, Bin Xu, Weidong Jiang, Haiyan Fu, Ruixiang Li, Hua Chen|2020|Org.Lett.|22|7814|doi:10.1021/acs.orglett.0c02679
DOI: 10.5517/ccdc.csd.cc24lz5x
title: CCDC 1984439: Experimental Crystal Structure Determination

description: Related Article: Wenjing Li, Juan Tang, Shun Li, Xueli Zheng, Maolin Yuan, Bin Xu, Weidong Jiang, Haiyan Fu, Ruixiang Li, Hua Chen|2020|Org.Lett.|22|7814|doi:10.1021/acs.orglett.0c02679
DOI: 10.5517/ccdc.csd.cc246lfd
title: CCDC 1972543: Experimental Crystal Structure Determination

description: Related Article: Shuang Huang, Xi Hong, He-Zhen Cui, Bing Zhan, Zhi-Ming Li, Xiu-Feng Hou|2020|Organometallics|39|3514|doi:10.1021/acs.organomet.0c00464
DOI: 10.5517/ccdc.csd.cc25h4pj
title: CCDC 2010557: Experimental Crystal Structure Determination

description: Related Article: A-Xiang Song, Xiao-Xiao Zeng, Bei-Bei Ma, Chang Xu, Feng-Shou Liu|2020|Organometallics|39|3524|doi:10.1021/acs.organomet.0c00494
DOI: 10.5517/ccdc.csd.cc25mx2t
title: CCDC 2015126: Experimental Crystal Structure Determination

description: Related Article: Zheng-Wang Shen, Die-Die Meng, Sajid Imran, Chun-Hui Yan, Hong-Mei Sun|2020|Organometallics|39|3540|doi:10.1021/acs.organomet.0c00515
DOI: 10.5517/ccdc.csd.cc25mx5x
title: CCDC 2015129: Experimental Crystal Structure Determination

description: Related Article: Zheng-Wang Shen, Die-Die Meng, Sajid Imran, Chun-Hui Yan, Hong-Mei Sun|2020|Organometallics|39|3540|doi:10.1021/acs.organomet.0c00515
DOI: 10.6084/m9.figshare.13106623
title: Supporting Datasets from Early life variations in temperature exposure affect the epigenetic regulation of the paraventricular nucleus in female rat pups

description: Compiled Datasets for the Temperature, Maternal Care, qPCR, DNA methylation, and ChIP results.
DOI: 10.6084/m9.figshare.13106623.v2
title: Supporting Datasets from Early life variations in temperature exposure affect the epigenetic regulation of the paraventricular nucleus in female rat pups

description: Compiled Datasets for the Temperature, Maternal Care, qPCR, DNA methylation, and ChIP results.
DOI: 10.6084/m9.figshare.13106623.v1
title: Supporting Datasets from Early life variations in temperature exposure affect the epigenetic regulation of the paraventricular nucleus in female rat pups

description: Compiled Datasets for the Temperature, Maternal Care, qPCR, DNA methylation, and ChIP results.
DOI: 10.6084/m9.figshare.13129538.v1
title: Arctic COSMO-CLM Reanalysis 1993

description: COSMO-CLM Russian Arctic climate dataset
DOI: 10.6084/m9.figshare.13129037.v1
title: Arctic COSMO-CLM Reanalysis 1992

description: COSMO-CLM Russian Arctic climate dataset
DOI: 10.6084/m9.figshare.13128734.v1
title: Arctic COSMO-CLM Reanalysis 1991

description: COSMO-CLM Russian Arctic climate dataset
DOI: 10.6084/m9.figshare.13110029.v2
title: Arctic Reanalysis COSMO-CLM 2012

description: COSMO-CLM Russain Arctic climate dataset
DOI: 10.6084/m9.figshare.13109567.v1
title: Arctic Reanalysis COSMO-CLM 2011

description: COSMO-CLM Russian Arctic climate dataset
DOI: 10.6084/m9.figshare.13109435.v1
title: Arctic Reanalysis COSMO-CLM 2010

description: COSMO-CLM Russian Arctic climate dataset
DOI: 10.6084/m9.figshare.13109402.v1
title: Arctic Reanalysis COSMO-CLM 2003

description: COSMO-CLM Russian Arctic climate dataset
DOI: 10.6084/m9.figshare.13108286.v1
title: Arctic Reanalysis COSMO-CLM 2002

description: COSMO-CLM Russian Arctic climate dataset
DOI: 10.6084/m9.figshare.13108208.v1
title: Arctic Reanalysis COSMO-CLM 2001

description: COSMO-CLM Russian Arctic climate dataset
DOI: 10.6084/m9.figshare.13108157.v1
title: Arctic Reanalysis COSMO-CLM 1989

description: COSMO-CLM Russian Arctic climate dataset
DOI: 10.6084/m9.figshare.13108124.v1
title: Arctic Reanalysis COSMO-CLM 1988

description: COSMO-CLM Russian Arctic climate dataset
DOI: 10.6084/m9.figshare.13108034.v1
title: Arctic Reanalysis COSMO-CLM 1987

description: COSMO-CLM Russia Arctic climate dataset
DOI: 10.6084/m9.figshare.13107968.v1
title: Arctic Reanalysis COSMO-CLM 1986

description: COSMO-CLM Russian Arctic climate dataset
DOI: 10.6084/m9.figshare.13107929.v2
title: Arctic Reanalysis COSMO-CLM 1985

description: COSMO-CLM Russian Arctic climate dataset
DOI: 10.6084/m9.figshare.13107872.v1
title: Arctic Reanalysis COSMO-CLM 1984

description: COSMO-CLM Russian Arctic climate dataset
DOI: 10.6084/m9.figshare.13105574.v1
title: Arctic Reanalysis COSMO-CLM 1983

description: COSMO-CLM Russian Arctic climate dataset
DOI: 10.6084/m9.figshare.13105427.v1
title: Arctic Reanalysis COSMO-CLM 1982

description: COSMO-CLM Russian Arctic climate dataset
DOI: 10.6084/m9.figshare.13103477.v1
title: Arctic Reanalysis COSMO-CLM 1981

description: COSMO-CLM Russian Arctic climate reanalysis
DOI: 10.6084/m9.figshare.13103258.v1
title: Arctic Reanalysis COSMO-CLM 1990

description: COSMO-CLM Russian Arctic climate dataset
DOI: 10.23679/502
title: Bulk rock δ13C and δ18O data from Darriwilian carbonates of Baltoscandia
title: Baltoskandia Darriwili lademe karbonaatkivimite δ13C and δ18O kogukivimi andmestik

description: Stable isotope composition of carbonates has been analysed from Darriwilian interval of the Baltoscandian Palaeobasin. Bulk rock δ13C and δ18O data of 446 whole-rock samples collected from 6 outcrop and 4 drillcore sections in Estonia, Latvia, Lithuania, Sweden, and NW Russia. Samples were analysed using a Thermo Fisher Scientific Delta V Advantage mass spectrometers in the Department of Geology, University of Tartu and in the Department of Geology at the Tallinn University of Technology.
DOI: 10.23679/503
title: Ostracod abundances in the Jurmala core
title: Ostrakoodide esinemissagedused Jurmala puursüdamikus

description: The distribution of ostracods in the Ordovician–Silurian boundary interval in the Jurmala core section, Latvia, was studied at the Department of Geology, Institute of Earth Sciences and Ecology, University of Tartu. The material was obtained from the samples of approximate weight 300-500 g by disintegration using sodium hyposulphite as a crystallizing agent. Ostracods were picked from the finely dispersed washed and dried residue (fraction 0.25−2 mm) under a binocular microscope, magnification x20...30. Specimen counting was performed in course of identification and all larger identifiable fragments, valves and complete (bivalved) specimens were counted on equal basis (as one specimen).
DOI: 10.25934/00005579.0
title: Available IPD datapackage for study 'A Phase III, Randomized, Double-Blind, Placebo-Controlled, Multicenter Study To Evaluate the Efficacy and Safety Of Bevacizumab, and Associated Biomarkers, In Combination With Paclitaxel Compared With Paclitaxel Plus Placebo as First-line Treatment Of Patients With Her2-Negative Metastatic Breast Cancer'

description: Vivli is an independent, non-profit organization that has developed a global data-sharing and analytics platform to serve all elements of the international research community. Our mission is to promote, coordinate, and facilitate scientific sharing and reuse of clinical research data through the creation and implementation of a sustainable global data-sharing enterprise. The Vivli platform includes an independent data repository, in-depth search engine and a cloud-based, secure analytics platform.
DOI: 10.5281/zenodo.4120241
title: The impacts of sub-grid physical processes on SEP air-sea fluxes

description: Model outputs from CAM5_CLUBB when parameters of ZM deep convection and CLUBB scheme are disturbed in SEP, ITCZ and SPCZ, respectively. And observations of surface energy fluxes.
DOI: 10.25934/00005579.1
title: IPD datapackage for study 'A Phase III, Randomized, Double-Blind, Placebo-Controlled, Multicenter Study To Evaluate the Efficacy and Safety Of Bevacizumab, and Associated Biomarkers, In Combination With Paclitaxel Compared With Paclitaxel Plus Placebo as First-line Treatment Of Patients With Her2-Negative Metastatic Breast Cancer' and research request: 'Effectiveness of cytotoxic chemotherapy for the treatment metastatic breast cancer subtypes (Garfin 11387)'

description: Vivli is an independent, non-profit organization that has developed a global data-sharing and analytics platform to serve all elements of the international research community. Our mission is to promote, coordinate, and facilitate scientific sharing and reuse of clinical research data through the creation and implementation of a sustainable global data-sharing enterprise. The Vivli platform includes an independent data repository, in-depth search engine and a cloud-based, secure analytics platform.
DOI: 10.5281/zenodo.4120240
title: The impacts of sub-grid physical processes on SEP air-sea fluxes

description: Model outputs from CAM5_CLUBB when parameters of ZM deep convection and CLUBB scheme are disturbed in SEP, ITCZ and SPCZ, respectively. And observations of surface energy fluxes.
DOI: 10.25934/00005813
title: Effectiveness of cytotoxic chemotherapy for the treatment metastatic breast cancer subtypes (Garfin 11387)

description: Vivli is an independent, non-profit organization that has developed a global data-sharing and analytics platform to serve all elements of the international research community. Our mission is to promote, coordinate, and facilitate scientific sharing and reuse of clinical research data through the creation and implementation of a sustainable global data-sharing enterprise. The Vivli platform includes an independent data repository, in-depth search engine and a cloud-based, secure analytics platform.
DOI: 10.5281/zenodo.4120318
title: Effort data from the FLT Mediterranean Network 2008-2018

description: Effort data used for the analysis presented in the manuscript "Trends in summer presence of fin whales in the Western Mediterranean Sea Region: new insights from a long-term monitoring program" - submitted for publication on PeerJ. Shape file represent transect monitored under favourable weather condition (sea state &lt;=4) using ferries as platform of opportunity.
description: Additional info on the dataset can be found as supplementary material to the manuscript or by contacting paola.tepsich@cimafoundation.org
DOI: 10.5281/zenodo.4095258
title: Data set accompanying: Topology of the Warm plasma dispersion relation at the second Harmonic Electron Cyclotron Resonance Layer

description: The Warm Plasma Dispersion Relation, for waves in the electron cyclotron resonance range of frequencies, can be cast into the form of a bi-quadratic equation for $N_\perp$, where the coefficients are a function of $N_\perp^2$ and an iterative procedure is required to obtain a solution. However, this iterative procedure is not well understood and fails to converge towards a solution at the second harmonic resonance layer. In particular at higher densities where the wave can couple to an electron Bernstein wave.<br> This paper focuses on a solution to the poor convergence of the iterative method, enabling determination of the topology of the dispersion relation around the second harmonic using a fully relativistic code for oblique waves.<br> A feed-forward controller is proposed with the ability to adjust the rotation of a step of $N_\perp^2$ within the complex plane, while also limiting the step-size.<br> It is shown that implementation of the controller stabilizes unstable solutions, while improving overall robustness of the iteration. This allows the evaluation of the coupling between the fast extraordinary mode and electron Bernstein waves at the second harmonic electron cyclotron resonance layer, for non-perpendicularly propagating waves.
description: {"references": ["P.L. Joostens and E. Westerhof (2020) Topology of the Warm plasma dispersion relation at the second Harmonic Electron Cyclotron Resonance Layer, arXiv: 2010.08363"]}
DOI: 10.5281/zenodo.4095257
title: Data set accompanying: Topology of the Warm plasma dispersion relation at the second Harmonic Electron Cyclotron Resonance Layer

description: The Warm Plasma Dispersion Relation, for waves in the electron cyclotron resonance range of frequencies, can be cast into the form of a bi-quadratic equation for $N_\perp$, where the coefficients are a function of $N_\perp^2$ and an iterative procedure is required to obtain a solution. However, this iterative procedure is not well understood and fails to converge towards a solution at the second harmonic resonance layer. In particular at higher densities where the wave can couple to an electron Bernstein wave.<br> This paper focuses on a solution to the poor convergence of the iterative method, enabling determination of the topology of the dispersion relation around the second harmonic using a fully relativistic code for oblique waves.<br> A feed-forward controller is proposed with the ability to adjust the rotation of a step of $N_\perp^2$ within the complex plane, while also limiting the step-size.<br> It is shown that implementation of the controller stabilizes unstable solutions, while improving overall robustness of the iteration. This allows the evaluation of the coupling between the fast extraordinary mode and electron Bernstein waves at the second harmonic electron cyclotron resonance layer, for non-perpendicularly propagating waves.
description: {"references": ["P.L. Joostens and E. Westerhof (2020) Topology of the Warm plasma dispersion relation at the second Harmonic Electron Cyclotron Resonance Layer, arXiv: 2010.08363"]}
DOI: 10.5281/zenodo.4120406
title: Effort data from the FLT Mediterranean Network 2008-2018

description: Effort data used for the analysis presented in the manuscript "Trends in summer presence of fin whales in the Western Mediterranean Sea Region: new insights from a long-term monitoring program" - submitted for publication on PeerJ. Shape file represent transect monitored under favourable weather condition (sea state &lt;=4) using ferries as platform of opportunity.
description: Additional info on the dataset can be found as supplementary material to the manuscript or by contacting paola.tepsich@cimafoundation.org
DOI: 10.5281/zenodo.4120317
title: Effort data from the FLT Mediterranean Network 2008-2018

description: Effort data used for the analysis presented in the manuscript "Trends in summer presence of fin whales in the Western Mediterranean Sea Region: new insights from a long-term monitoring program" - submitted for publication on PeerJ. Shape file represent transect monitored under favourable weather condition (sea state &lt;=4) using ferries as platform of opportunity.
description: Additional info on the dataset can be found as supplementary material to the manuscript or by contacting paola.tepsich@cimafoundation.org
DOI: 10.5517/ccdc.csd.cc2661r7
title: CCDC 2031608: Experimental Crystal Structure Determination

description: Related Article: Haruka Homma, Shingo Harada, Tsubasa Ito, Ayaka Kanda, Tetsuhiro Nemoto|2020|Org.Lett.|22|8132|doi:10.1021/acs.orglett.0c03110
DOI: 10.21227/qkgp-8q43
title: Forecast Testing

description: Energy Forecasts
DOI: 10.5286/isis.e.rb1810120-3
title: Spin Dynamics of the Elemental Quantum Spin Liquid beta-Mn

description: The beta-phase of manganese metal is the only form which is non-magnetic at all temperatures and has been classified as an elemental metallic quantum spin liquid. This is thought to be due to the fact that the Mn spins are connected by interlocking 2d Ising triangular planes normal to (111) cubic directions. However, the spin-correlations in beta-Mn have never been properly measured, since this requires large incident energies with which to cover the massive spin-fluctuation bandwidth. Previous attempts to measure the full integrated S(Q) on HET were hampered by restrictive detector coverage and low resolution. We propose here to use the MAPS spectrometer to measure the magnetic S(Q) of pure beta-Mn in order to validate our spin-structure model, derived from single crystal Co-doped samples. We will require 2 days on MAPS to complete this study.
DOI: 10.6084/m9.figshare.12045582.v9
title: Integrated genetic analyses revealed novel human longevity loci and reduced risks of multiple diseases in a cohort study of 15,651 Chinese individuals

description: Supplementary tables for the Paper published
DOI: 10.5286/isis.e.rb2010062
title: Magnetic structure of non-centrosymmetric metal AgCrSe2

description: The aim of the proposed experiment is to establish the magnetic structure of non-centrosymmetric metallic antiferromagnet AgCrSe2 using both polycrystalline and single crystal samples. For the experiment on single crystal, we propose to use the WISH to collect a large number of reflections to properly refine the wavelength dependent extinction. The large number of reflections measured in the present experiment will allow for a comprehensive symmetry assisted refinement of the magnetic structure, including refinement of possible magnetic domain population.