cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.25586015
title: Serum globulin in children with myasthenia gravis: predicting relapse and prognosis

description: Serum globulin is associated with inflammatory or immune disorders. However, it has not been established whether it is associated with myasthenia gravis (MG). We investigated the association between globulin with relapse and prognosis in children with MG. A cohort of 148 MG cases and 150 healthy children were retrospectively enrolled from January 2015 to December 2021. Multivariate logistic and Cox regression models were used to analyze the treatment outcomes and recurrence of case group, exploring the influence of globulin. Compared with the control group, globulin levels in the MG group were slightly increased (<i>t</i> = 7.244, <i>p</i> &lt; 0.001). After a mean follow-up of 2.25 ± 1.05 years, 35 cases relapsed, with a relapse rate of 23.65%. Logistic regression analysis showed that globulin levels at admission [adjusted odds ratio (OR) = 1.233, 95% confidence interval (CI) 1.028–1.472, <i>p</i> = 0.018] were independent risk factors for relapse. Cox regression analysis confirmed that globulin levels at admission affects relapse-free time [adjusted hazard ratio (HR) = 0.552, 95% CI 0.357–0.852, <i>p</i> = 0.007]. Receiver operating characteristic curve determined 25.10 as the optimal cutoff value for globulin. Cox regression showed that high globulin levels (&gt;25.10) at admission (adjusted HR = 0.607, 95% CI 0.383–0.961, <i>p</i> = 0.033) were independent risk factors for poor therapeutic outcomes at follow-up. Ordinal logistic regression showed that globulin affects the treatment plan (OR = 1.445, 95% CI 1.223–1.847, <i>p</i> = 0.014). Elevated globulin levels in children with MG on admission predicts a high relapse rate and poor long-term therapeutic efficacies. Serum globulin in children with myasthenia gravis: predicting relapse and prognosisFirst, the globulin in the MG children was higher than in the healthy controls, and there was some correlation between the globulin and the level of systemic inflammation.Second, globulin has been associated with relapse of MG in children. The higher the globulin, the higher the relapse rate and the shorter the time to prevent a relapse.Third, both initial and final globulin were related to the effect of MG in children, and the higher the long-term effect, the worse the long-term effect. It also influenced the change in treatment plan. Serum globulin in children with myasthenia gravis: predicting relapse and prognosis First, the globulin in the MG children was higher than in the healthy controls, and there was some correlation between the globulin and the level of systemic inflammation. Second, globulin has been associated with relapse of MG in children. The higher the globulin, the higher the relapse rate and the shorter the time to prevent a relapse. Third, both initial and final globulin were related to the effect of MG in children, and the higher the long-term effect, the worse the long-term effect. It also influenced the change in treatment plan.
DOI: 10.6084/m9.figshare.25586015.v1
title: Serum globulin in children with myasthenia gravis: predicting relapse and prognosis

description: Serum globulin is associated with inflammatory or immune disorders. However, it has not been established whether it is associated with myasthenia gravis (MG). We investigated the association between globulin with relapse and prognosis in children with MG. A cohort of 148 MG cases and 150 healthy children were retrospectively enrolled from January 2015 to December 2021. Multivariate logistic and Cox regression models were used to analyze the treatment outcomes and recurrence of case group, exploring the influence of globulin. Compared with the control group, globulin levels in the MG group were slightly increased (<i>t</i> = 7.244, <i>p</i> &lt; 0.001). After a mean follow-up of 2.25 ± 1.05 years, 35 cases relapsed, with a relapse rate of 23.65%. Logistic regression analysis showed that globulin levels at admission [adjusted odds ratio (OR) = 1.233, 95% confidence interval (CI) 1.028–1.472, <i>p</i> = 0.018] were independent risk factors for relapse. Cox regression analysis confirmed that globulin levels at admission affects relapse-free time [adjusted hazard ratio (HR) = 0.552, 95% CI 0.357–0.852, <i>p</i> = 0.007]. Receiver operating characteristic curve determined 25.10 as the optimal cutoff value for globulin. Cox regression showed that high globulin levels (&gt;25.10) at admission (adjusted HR = 0.607, 95% CI 0.383–0.961, <i>p</i> = 0.033) were independent risk factors for poor therapeutic outcomes at follow-up. Ordinal logistic regression showed that globulin affects the treatment plan (OR = 1.445, 95% CI 1.223–1.847, <i>p</i> = 0.014). Elevated globulin levels in children with MG on admission predicts a high relapse rate and poor long-term therapeutic efficacies. Serum globulin in children with myasthenia gravis: predicting relapse and prognosisFirst, the globulin in the MG children was higher than in the healthy controls, and there was some correlation between the globulin and the level of systemic inflammation.Second, globulin has been associated with relapse of MG in children. The higher the globulin, the higher the relapse rate and the shorter the time to prevent a relapse.Third, both initial and final globulin were related to the effect of MG in children, and the higher the long-term effect, the worse the long-term effect. It also influenced the change in treatment plan. Serum globulin in children with myasthenia gravis: predicting relapse and prognosis First, the globulin in the MG children was higher than in the healthy controls, and there was some correlation between the globulin and the level of systemic inflammation. Second, globulin has been associated with relapse of MG in children. The higher the globulin, the higher the relapse rate and the shorter the time to prevent a relapse. Third, both initial and final globulin were related to the effect of MG in children, and the higher the long-term effect, the worse the long-term effect. It also influenced the change in treatment plan.
DOI: 10.15468/dl.udc0cn
title: Occurrence Download

description: A dataset containing 2828 species occurrences available in GBIF matching the query:
{
 "and" : [
 {
 "or" : [
 "BasisOfRecord is Human Observation",
 "BasisOfRecord is Observation",
 "BasisOfRecord is Specimen"
 ]
 },
 "Country is Mexico",
 "TaxonKey is Didelphis virginiana Kerr, 1792",
 "HasGeospatialIssue is false"
 ]
}

 The dataset includes 2828 records from 75 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0024479-190415153152247/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.6084/m9.figshare.25586617
title: microRNA-mRNA expression profiles in the skeletal muscle of myotonic dystrophy type 1

description: Myotonic dystrophy type 1 (DM1) is the most common muscular dystrophy in adults, yet there are currently no disease-modifying treatments. Disrupted miRNA expressions may lead to dysregulation of target mRNAs and dysfunction involved in DM1 pathogenic mechanism. We used microarray platforms to examine the miRNA/mRNA expression profiles in skeletal muscle biopsies derived from DM1 patients and matched controls. Bioinformatics analysis and dual-luciferase reporter assay were conducted to provide insight into miRNA-mRNA regulatory networks altered in DM1. Twenty-three differentially expressed miRNAs and 135 differentially expressed genes were identified. qPCR confirmed that miR-3201, myogenic factor 5 (MYF5), myogenic differentiation 1 (MYOD1), CUGBP, Elav-like family member 1 (CELF1), and CELF2 were significantly up-regulated, while miR-196a, miR-200c, and miR-146a were significantly down-regulated. Enriched functions and pathways such as multicellular organismal development, RNA splicing, cell differentiation, and spliceosome are relevant to DM1. The miRNA-mRNA interaction network revealed that miR-182, miR-30c-2, and miR-200c were the critical nodes that potentially interacted with hub genes. Luciferase reporter assay confirmed the direct interaction between miR-196a and CELF2. Those results implied that the observed miRNA/mRNA dysregulation could contribute to specific functions and pathways related to DM1 pathogenesis, highlighting the dysfunction of miR-196a and CELF2.
DOI: 10.6084/m9.figshare.25586617.v1
title: microRNA-mRNA expression profiles in the skeletal muscle of myotonic dystrophy type 1

description: Myotonic dystrophy type 1 (DM1) is the most common muscular dystrophy in adults, yet there are currently no disease-modifying treatments. Disrupted miRNA expressions may lead to dysregulation of target mRNAs and dysfunction involved in DM1 pathogenic mechanism. We used microarray platforms to examine the miRNA/mRNA expression profiles in skeletal muscle biopsies derived from DM1 patients and matched controls. Bioinformatics analysis and dual-luciferase reporter assay were conducted to provide insight into miRNA-mRNA regulatory networks altered in DM1. Twenty-three differentially expressed miRNAs and 135 differentially expressed genes were identified. qPCR confirmed that miR-3201, myogenic factor 5 (MYF5), myogenic differentiation 1 (MYOD1), CUGBP, Elav-like family member 1 (CELF1), and CELF2 were significantly up-regulated, while miR-196a, miR-200c, and miR-146a were significantly down-regulated. Enriched functions and pathways such as multicellular organismal development, RNA splicing, cell differentiation, and spliceosome are relevant to DM1. The miRNA-mRNA interaction network revealed that miR-182, miR-30c-2, and miR-200c were the critical nodes that potentially interacted with hub genes. Luciferase reporter assay confirmed the direct interaction between miR-196a and CELF2. Those results implied that the observed miRNA/mRNA dysregulation could contribute to specific functions and pathways related to DM1 pathogenesis, highlighting the dysfunction of miR-196a and CELF2.
DOI: 10.15468/dl.y7wypm
title: Occurrence Download

description: A dataset containing 231 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Carex alopecoidea Tuck.",
 "BasisOfRecord is one of (Specimen)",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "Continent is North America"
 ]
}

 The dataset includes 231 records from 18 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0163904-200613084148143/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.g4v7h0
title: Occurrence Download

description: A dataset containing 7327 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is Mexico",
 "TaxonKey is Selaginella P.Beauv."
 ]
}

 The dataset includes 7327 records from 140 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0024489-180508205500799/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.2d3z8z
title: Occurrence Download

description: A dataset containing 28 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Dalea foliosa (A.Gray) Barneby",
 "BasisOfRecord is one of (Specimen)",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "Continent is North America"
 ]
}

 The dataset includes 28 records from 6 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0175488-200613084148143/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.ihuysw
title: Occurrence Download

description: A dataset containing 26 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Geometry POLYGON((-73.5071175989239 7.0881810535483964,-73.35868248070872 7.0707371921777735,-73.2629809035872 7.074613671017744,-73.20634119771955 7.128880727350733,-73.16142002342622 7.18507916112074,-73.16532622545253 7.314890209906537,-73.19657572990609 7.373002322389581,-73.26493400460036 7.429170181648772,-73.30399587585424 7.481457893527065,-73.38407268212282 7.485330825059819,-73.5129768833372 7.456283112147162,-73.60477227705857 7.427233471748551,-73.63797486389913 7.351695409200673,-73.65750579952606 7.2509580488333825,-73.65750579952606 7.140508595197005,-73.5071175989239 7.0881810535483964))",
 "HasCoordinate is true",
 "TaxonKey is Rodentia",
 "HasGeospatialIssue is false"
 ]
}

 The dataset includes 26 records from 6 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0024484-180131172636756/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.q73hbv
title: Occurrence Download

description: A dataset containing 291 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Morpho peleides Kollar, 1850"
 ]
}

 The dataset includes 291 records from 28 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0151455-200613084148143/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.uiiill
title: Occurrence Download

description: A dataset containing 47 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is Ecuador",
 "Geometry POLYGON((-77.3811 0.67674,-78.45337 -1.22159,-79.78931 -4.64432,-79.01587 -5.36227,-78.11938 -4.10099,-77.85571 -3.31163,-76.20337 -2.57433,-75.67603 -2.15281,-74.93774 -0.65916,-75.42993 0.30762,-76.18579 0.60643,-77.3811 0.67674))",
 "HasCoordinate is true",
 "TaxonKey is Sterculia frondosa Rich.",
 "HasGeospatialIssue is false"
 ]
}

 The dataset includes 47 records from 3 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0024484-180508205500799/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.wfkhbb
title: Occurrence Download

description: A dataset containing 119752 species occurrences available in GBIF matching the query:
{
 "GadmGid" : [
 "is RUS.35_1"
 ]
}

 The dataset includes 119752 records from 251 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0163853-200613084148143/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.nzdm9l
title: Occurrence Download

description: A dataset containing 12148 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Sedum annuum L."
 ]
}

 The dataset includes 12148 records from 100 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0024482-160910150852091/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.r7un6u
title: Occurrence Download

description: A dataset containing 1180 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Dalea candida Willd.",
 "BasisOfRecord is one of (Specimen)",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "Continent is North America"
 ]
}

 The dataset includes 1180 records from 16 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0175485-200613084148143/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.8ybamz
title: Occurrence Download

description: A dataset containing 206201 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is Mexico",
 "TaxonKey is Trochilidae"
 ]
}

 The dataset includes 206201 records from 134 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0024485-181108115102211/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.7setnp
title: Occurrence Download

description: A dataset containing 1574741 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is China",
 "OccurrenceStatus is Present",
 "Year 1000-1960"
 ]
}

 The dataset includes 1574741 records from 805 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0182395-200613084148143/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.wcd3sy
title: Occurrence Download

description: A dataset containing 92 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is Mexico",
 "Year 1970-2019",
 "HasCoordinate is true",
 "TaxonKey is Desmoncus quasillarius Bartlett",
 "HasGeospatialIssue is false"
 ]
}

 The dataset includes 92 records from 15 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0024485-190415153152247/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.r53cyz
title: Occurrence Download

description: A dataset containing 2 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is Mexico",
 "OccurrenceStatus is Present",
 {
 "or" : [
 "StateProvince is OAXAcA",
 "StateProvince is Puebla",
 "StateProvince is HIdalgo",
 "StateProvince is Queretaro"
 ]
 },
 "TaxonKey is Ophioglossum nudicaule L.f."
 ]
}

 The dataset includes 2 records from 2 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0186879-200613084148143/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.ehe2kv
title: Occurrence Download

description: A dataset containing 389 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Geometry POLYGON((-126.03515624999999 21.845187762357327,-108.45703124999997 22.17113149442808,-98.96484374999997 30.660599519588175,-98.61328124999997 46.486293526486975,-102.48046874999997 58.576274543096616,-127.08984374999999 62.867174841886396,-145.01953124999997 59.48080274689863,-149.58984374999997 40.36663995568577,-126.03515624999999 21.845187762357327))",
 "TaxonKey is Rhamnus purshiana (Pursh) DC."
 ]
}

 The dataset includes 389 records from 12 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0024486-180131172636756/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15156/bio/sh1161779.10fu
title: SH1161779.10FU

description: UNITE provides a unified way for delimiting, identifying, communicating, and working with DNA-based Species Hypotheses (SH). All fungal ITS sequences in the international nucleotide sequence databases are clustered to approximately the species level by applying a set of dynamic distance values (<0.5 - 3.0%). All species hypotheses are given a unique, stable name in the form of a DOI, and their taxonomic and ecological annotations are verified through distributed, web-based third-party annotation efforts. SHs are connected to a taxon name and its classification as far as possible (phylum, class, order, etc.) by taking into account identifications for all sequences in the SH. An automatically or manually designated sequence is chosen to represent each such SH. These sequences are released (https://unite.ut.ee/repository.php) for use by the scientific community in, for example, local sequence similarity searches and next-generation sequencing analysis pipelines. The system and the data are updated automatically as the number of public fungal ITS sequences grows.
DOI: 10.15156/bio/sh1161780.10fu
title: SH1161780.10FU

description: UNITE provides a unified way for delimiting, identifying, communicating, and working with DNA-based Species Hypotheses (SH). All fungal ITS sequences in the international nucleotide sequence databases are clustered to approximately the species level by applying a set of dynamic distance values (<0.5 - 3.0%). All species hypotheses are given a unique, stable name in the form of a DOI, and their taxonomic and ecological annotations are verified through distributed, web-based third-party annotation efforts. SHs are connected to a taxon name and its classification as far as possible (phylum, class, order, etc.) by taking into account identifications for all sequences in the SH. An automatically or manually designated sequence is chosen to represent each such SH. These sequences are released (https://unite.ut.ee/repository.php) for use by the scientific community in, for example, local sequence similarity searches and next-generation sequencing analysis pipelines. The system and the data are updated automatically as the number of public fungal ITS sequences grows.
DOI: 10.15156/bio/sh1161781.10fu
title: SH1161781.10FU

description: UNITE provides a unified way for delimiting, identifying, communicating, and working with DNA-based Species Hypotheses (SH). All fungal ITS sequences in the international nucleotide sequence databases are clustered to approximately the species level by applying a set of dynamic distance values (<0.5 - 3.0%). All species hypotheses are given a unique, stable name in the form of a DOI, and their taxonomic and ecological annotations are verified through distributed, web-based third-party annotation efforts. SHs are connected to a taxon name and its classification as far as possible (phylum, class, order, etc.) by taking into account identifications for all sequences in the SH. An automatically or manually designated sequence is chosen to represent each such SH. These sequences are released (https://unite.ut.ee/repository.php) for use by the scientific community in, for example, local sequence similarity searches and next-generation sequencing analysis pipelines. The system and the data are updated automatically as the number of public fungal ITS sequences grows.
DOI: 10.15156/bio/sh1161785.10fu
title: SH1161785.10FU

description: UNITE provides a unified way for delimiting, identifying, communicating, and working with DNA-based Species Hypotheses (SH). All fungal ITS sequences in the international nucleotide sequence databases are clustered to approximately the species level by applying a set of dynamic distance values (<0.5 - 3.0%). All species hypotheses are given a unique, stable name in the form of a DOI, and their taxonomic and ecological annotations are verified through distributed, web-based third-party annotation efforts. SHs are connected to a taxon name and its classification as far as possible (phylum, class, order, etc.) by taking into account identifications for all sequences in the SH. An automatically or manually designated sequence is chosen to represent each such SH. These sequences are released (https://unite.ut.ee/repository.php) for use by the scientific community in, for example, local sequence similarity searches and next-generation sequencing analysis pipelines. The system and the data are updated automatically as the number of public fungal ITS sequences grows.