cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.5286/isis.e/isis.e.rb2410144
title: Determine the structure of the KRAS:BRAF complex on tethered lipid bilayers using neutron reflectivity

description: Ras genes are the most frequently mutated oncogenes in human cancer, and the KRAS isoform is mutated in 95% of pancreatic cancer. KRAS is peripherally localized at the plasma membrane and, when activated, binds effector proteins such as BRAF. KRAS signaling is enhanced during cancer, and the KRAS/BRAF complex at the lipid membrane is a high-value target in the search for intervening drugs. This proposal seeks to obtain a low-resolution structure of the KRAS/BRAF complex using neutron reflectometry as part of a broader biophysical characterization effort of this potential drug target. Neutron reflectometry is one of the few techniques that yield structural information on this class of peripheral and conformational flexible membrane proteins and is essential for this effort.
DOI: 10.5286/isis.e/isis.e.rb2410144-1
title: Determine the structure of the KRAS:BRAF complex on tethered lipid bilayers using neutron reflectivity

description: Ras genes are the most frequently mutated oncogenes in human cancer, and the KRAS isoform is mutated in 95% of pancreatic cancer. KRAS is peripherally localized at the plasma membrane and, when activated, binds effector proteins such as BRAF. KRAS signaling is enhanced during cancer, and the KRAS/BRAF complex at the lipid membrane is a high-value target in the search for intervening drugs. This proposal seeks to obtain a low-resolution structure of the KRAS/BRAF complex using neutron reflectometry as part of a broader biophysical characterization effort of this potential drug target. Neutron reflectometry is one of the few techniques that yield structural information on this class of peripheral and conformational flexible membrane proteins and is essential for this effort.
DOI: 10.34816/ifao.archives.232797
title: SAQQARA_nb_1994_06022

description: Référence : nb_1994_06022<br />Site : Saqqara<br />Secteur : Mastaba de Ti<br />Type : photographie<br />
DOI: 10.3535/9hh-h2r-w6e
title: Poa L.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/cgk-x79-fv8
title: Agrostis L.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.5286/isis.e/isis.e.rb2410051-1
title: SHINING THE BEAM ON EGYPTIAN MUMMIES IN TOSCA - EFFECTS OF FIRE ON THE EGYPTIAN COLLECTION OF THE NATIONAL MUSEUM-BRAZIL

description: Inelastic neutron scattering spectroscopy in TOSCA will be applied to analyse skeletal remains from mummies of the Egyptian Collection of the brazilian National Museum, which were damaged by fire in 2018. 4 different mummies will be probed, including a particularly interesting one from the Roman Period due to its specific mummification process (1 among 7 worldwide). Based on the team´s previous expertise in the analysis of burned human bones by vibrational spectroscopy, the present results are expected to deliver the burning conditions, and to determine the impact of the mummification process on the heat-induced effects in bone. Understanding how fire affected these mummified bones is a crucial step for the preservation of the Museum´s collection. This is a pioneer neutron study on mummified human bones subjected to burning.
DOI: 10.5286/isis.e/isis.e.rb2410064
title: SANS investigations of the condensates between SARS-CoV-2 nucleocapsid protein and model viral RNA

description: This proposal aims to study the internal structure of the aggregates formed by the SARS-CoV-2 Nucleocapsid (N) protein and RNA, a relevant information for the development of possible therapies. Indeed, N-protein is positively charged at neutral pH, so it shows a strong binding affinity with negatively charged RNAs. Moreover, previous gel filtration and DLS results suggested N-protein oligomerization [1]. Since these features are similar to those of other proteins that have been reported to undergo liquid–liquid phase separation (LLPS) with nucleic acids, we propose to study the in-solution structural and aggregational features of the N-protein in the presence of a model RNA by fully exploiting the contrast variation SANS technique.
For the proposed study, we have already produced the SARS-CoV-2 N-protein through the recombinant DNA technology and we will take advantage of recent fluorescence results that evidence how, at fixed N-protein concentration, liquid-like droplets form at high RNA concentrations. GENFIT software will be used to obtain the form factor of the N-protein in solution, the form factor of the protein inside the condensates, and, finally, the structure factor that describes the correlation between proteins within the condensates.
DOI: 10.5286/isis.e/isis.e.rb2410064-1
title: SANS investigations of the condensates between SARS-CoV-2 nucleocapsid protein and model viral RNA

description: This proposal aims to study the internal structure of the aggregates formed by the SARS-CoV-2 Nucleocapsid (N) protein and RNA, a relevant information for the development of possible therapies. Indeed, N-protein is positively charged at neutral pH, so it shows a strong binding affinity with negatively charged RNAs. Moreover, previous gel filtration and DLS results suggested N-protein oligomerization [1]. Since these features are similar to those of other proteins that have been reported to undergo liquid–liquid phase separation (LLPS) with nucleic acids, we propose to study the in-solution structural and aggregational features of the N-protein in the presence of a model RNA by fully exploiting the contrast variation SANS technique.
For the proposed study, we have already produced the SARS-CoV-2 N-protein through the recombinant DNA technology and we will take advantage of recent fluorescence results that evidence how, at fixed N-protein concentration, liquid-like droplets form at high RNA concentrations. GENFIT software will be used to obtain the form factor of the N-protein in solution, the form factor of the protein inside the condensates, and, finally, the structure factor that describes the correlation between proteins within the condensates.
DOI: 10.3535/46c-72t-858
title: Rhytachne triaristata (Steud.) Stapf

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.5286/isis.e/isis.e.rb2410051
title: SHINING THE BEAM ON EGYPTIAN MUMMIES IN TOSCA - EFFECTS OF FIRE ON THE EGYPTIAN COLLECTION OF THE NATIONAL MUSEUM-BRAZIL

description: Inelastic neutron scattering spectroscopy in TOSCA will be applied to analyse skeletal remains from mummies of the Egyptian Collection of the brazilian National Museum, which were damaged by fire in 2018. 4 different mummies will be probed, including a particularly interesting one from the Roman Period due to its specific mummification process (1 among 7 worldwide). Based on the team´s previous expertise in the analysis of burned human bones by vibrational spectroscopy, the present results are expected to deliver the burning conditions, and to determine the impact of the mummification process on the heat-induced effects in bone. Understanding how fire affected these mummified bones is a crucial step for the preservation of the Museum´s collection. This is a pioneer neutron study on mummified human bones subjected to burning.
DOI: 10.5286/isis.e/isis.e.rb2420378-1
title: Magnetic ordering in the nanolaminated MAX phase (Mn,Cr)2GaC

description: MAX phases are a class of intrinsically nanolaminated materials which combine features of metals and ceramics, owing to the alternating metallic and covalent bonding between layers. Magnetic MAX phases have been known for a decade but ferromagnetism at room temperature has been elusive, limiting their value as magnets in practice. We have shown for the first time that a MAX phase with a strong ferromagnetic-like response is obtained by alloying with Cr on the M-site in (Mn,Cr)2GaC up to temperatures well exceeding room temperature (489 K). However, the exact nature of the magnetic ordering is unknown and neutron diffraction measurements are required to determine if the ordering is ferromagnetic, ferrimagnetic or some other more complex non-collinear order. We propose performing single-crystal neutron diffraction measurements at the WISH beamline to determine the magnetic ordering and explain the origin of the high remanent moment. This will allow the continued optimization of this complex alloy, with potential applications ranging from bulk magnets in power electronics to spintronic devices.
DOI: 10.5286/isis.e/isis.e.rb2455016
title: High Fidelity Residual Stress Measurement for High Speed Flywheel Rotor Stress
DOI: 10.5286/isis.e/isis.e.rb2455016-1
title: High Fidelity Residual Stress Measurement for High Speed Flywheel Rotor Stress
DOI: 10.34816/ifao.archives.232798
title: SAQQARA_nb_1994_06031

description: Référence : nb_1994_06031<br />Site : Saqqara<br />Secteur : Mastaba de Ti<br />Type : photographie<br />
DOI: 10.3535/0cm-1l7-fax
title: Carex pachystylis J.Gay

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/2y8-4k3-vvb
title: Glebionis coronaria (L.) Tzvelev

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.5286/isis.e/isis.e.rb2310191
title: Copy of Novel ground state in a new frustrated kagome antiferromagnet: YCu6O8Cl

description: Frustrated kagomé antiferromagnet consists of corner sharing triangles of magnetic moments offers a unique two dimensional spin- lattice to realize exotic phenomena such as quantum spin liquids (QSL) and associated elementary excitations. Quantum spin liquid is a highly entangled state ideal to host fractional excitations coupled to emergent gauge fields and has immense potential for braiding quantum computing technology. Here, we focus on a new Cu-based frustrated magnet YCu6O8Cl, wherein Cu ions constitute a two-dimensional kagome spin-lattice. Neither magnetic susceptibility nor specific-heat data show any signature of magnetic ordering down to 1.9 K despite a large Curie-Weiss temperature of Ѳcw = - 380 K. The magnetic specific heat suggests the presence of a gapless excitation spectrum. We propose to perform low energy inelastic neutron scattering (INS) studies using OSIRIS and high energy INS study on MERLIN for the unambiguous identification of ground state and track the associated magnetic excitations in this new quantum kagome frustrated magnet
DOI: 10.5286/isis.e/isis.e.rb2310191-1
title: Copy of Novel ground state in a new frustrated kagome antiferromagnet: YCu6O8Cl

description: Frustrated kagomé antiferromagnet consists of corner sharing triangles of magnetic moments offers a unique two dimensional spin- lattice to realize exotic phenomena such as quantum spin liquids (QSL) and associated elementary excitations. Quantum spin liquid is a highly entangled state ideal to host fractional excitations coupled to emergent gauge fields and has immense potential for braiding quantum computing technology. Here, we focus on a new Cu-based frustrated magnet YCu6O8Cl, wherein Cu ions constitute a two-dimensional kagome spin-lattice. Neither magnetic susceptibility nor specific-heat data show any signature of magnetic ordering down to 1.9 K despite a large Curie-Weiss temperature of Ѳcw = - 380 K. The magnetic specific heat suggests the presence of a gapless excitation spectrum. We propose to perform low energy inelastic neutron scattering (INS) studies using OSIRIS and high energy INS study on MERLIN for the unambiguous identification of ground state and track the associated magnetic excitations in this new quantum kagome frustrated magnet
DOI: 10.5286/isis.e/isis.e.rb2420378
title: Magnetic ordering in the nanolaminated MAX phase (Mn,Cr)2GaC

description: MAX phases are a class of intrinsically nanolaminated materials which combine features of metals and ceramics, owing to the alternating metallic and covalent bonding between layers. Magnetic MAX phases have been known for a decade but ferromagnetism at room temperature has been elusive, limiting their value as magnets in practice. We have shown for the first time that a MAX phase with a strong ferromagnetic-like response is obtained by alloying with Cr on the M-site in (Mn,Cr)2GaC up to temperatures well exceeding room temperature (489 K). However, the exact nature of the magnetic ordering is unknown and neutron diffraction measurements are required to determine if the ordering is ferromagnetic, ferrimagnetic or some other more complex non-collinear order. We propose performing single-crystal neutron diffraction measurements at the WISH beamline to determine the magnetic ordering and explain the origin of the high remanent moment. This will allow the continued optimization of this complex alloy, with potential applications ranging from bulk magnets in power electronics to spintronic devices.
DOI: 10.3535/gtm-9vy-q4l
title: Calamagrostis stricta (Timm) Koeler

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/k48-ayh-bt0
title: Catabrosa aquatica (L.) P.Beauv.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.5286/isis.e/isis.e.rb2490210-1
title: Neutron scattering study of a new para-dihydroxybenzene phase
DOI: 10.5286/isis.e/isis.e.rb2490212-1
title: Evaluation of Magnetic Excitations and Nature of Spin Waves in Spin-1/2 1D Chain Quantum Spin Liquid Ground State of ZnCoP2O7
DOI: 10.34816/ifao.archives.232799
title: SAQQARA_nb_1994_06040

description: Référence : nb_1994_06040<br />Site : Saqqara<br />Secteur : Mastaba de Ti<br />Type : photographie<br />
DOI: 10.3535/l1j-tgn-9tb
title: Bromus diandrus Roth

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/zb5-c34-rq1
title: Festuca Tourn. ex L.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.5286/isis.e/isis.e.rb2490215-1
title: Magnetic excitations in 1D spin-5/2 chains of BaMn2V2O8
DOI: 10.5286/isis.e/isis.e.rb2490217
title: Inelastic Neutron Scattering on Ni4Nb2O9
DOI: 10.5286/isis.e/isis.e.rb2490217-1
title: Inelastic Neutron Scattering on Ni4Nb2O9
DOI: 10.3535/9s7-7t8-dat
title: Atriplex L.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/l0p-6aw-bnm
title: Oleaceae

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.5286/isis.e/isis.e.rb2300013-2
title: Structural study of high-pressure cubic inclusion compound of arsenic(III) oxide with deuterium

description: Studying of hydrogen (and deuterium) inclusion compounds is vital to elucidate details of hydrogen dynamics and its interactions with host material. The interest in them is justified by the prediction that hydrogen-rich compounds are expected to be high-temperature superconductors. We propose to carry out neutron powder diffraction study of arsenic(III) oxide inclusion compound with deuterium at high pressure, at room and low temperature. The goal of the experiments is to elucidate exact stoichiometry and a better crystal structure model of the compound. We also hope to gain insight into the dynamics of hydrogen molecules.
DOI: 10.5286/isis.e/isis.e.rb2310624-1
title: Phonon anomalies and structural instabilities in TbScO3 (MERLIN)

description: Distorted perovskite TbScO3 is a particularly interesting lanthanide scandate, exhibiting a dramatic flexoelectric effect, along with the common features of the wider family of lanthanide scandates. Accurate knowledge of its structure and dynamics is of particular importance, for example due to its use as a substrate for epitaxial growth of high-quality perovskite thin films. However, the structure and dynamics of this material at low temperatures are not properly understood. We plan to investigate these by combining phonon studies with powder and single crystal neutron diffraction. Powder diffraction on HRPD and single crystal diffraction on SXD will be used to study structural models and characterise subtle distortions of this material. Phonon spectrometry on MERLIN – preceded by careful phonon characterization using CASTEP with Horace and the Euphonic package – will be used to clarify discrepancies between phonon modes allowed by symmetry and those previously experimentally observed.
DOI: 10.5286/isis.e/isis.e.rb2490223-1
title: Crystal structure of Tm-doped BaF2
DOI: 10.34816/ifao.archives.232800
title: SAQQARA_nb_1994_06047

description: Référence : nb_1994_06047<br />Site : Saqqara<br />Secteur : Mastaba de Ti<br />Type : photographie<br />
DOI: 10.3535/wpb-6ra-9hh
title: Reseda L.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.5286/isis.e/isis.e.rb2368063-2
title: Muon Spin Rotation and Relaxation Study of Ferrimagnetic Sodium-rich Manganese Hexacyanoferrate Energy Material with Open Framework

description: The alkali metal ion-based batteries is the key component of electrical vehicles and future of renewable energy sources for grid technology. Therefore, their demands are continuously increasing day by day with better capacities and longer life cyles. However, addressing these demands require, design and development of new battery materials with a better understanding of ion diffusion beacuse ion diffusion in batteries is the basic principle by which these devices function. Therefore, the proposed muon spin rotation and relaxation study suing EMU instrument, is to understand the origin of microscopic Na+ ion diffusion mechanism in Na2xMn[Fe(CN)6]2(x+1)/3·zH2O (x= 0, 0.5 and 1) Prussian blue analouges (PBAs) energy storage materials. This will be a first experimental study to reveal micro transport properties of PBAs molecular magnets-based energy materials.
DOI: 10.5286/isis.e/isis.e.rb2455003-2
title: Residual Stress Testing of the Mirror Structure for the ESA ATHENA Mission Telescope
DOI: 10.3535/cfv-r0k-gh7
title: Schizachyrium brevifolium (Sw.) Nees ex Buse

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/gj3-461-f47
title: Hyparrhenia involucrata Stapf

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.5286/isis.e/isis.e.rb2220739-1
title: Measuring absorption coefficient of Si using photoexcited muon spin spectroscopy

description: Here we propose a photoexcited muon spin spectroscopy experiment to measure absorption coefficient - a key parameter in optical/photovoltaic applications in semiconductor engineering. We plan to utilize the photo-uSR technique originally developed for measuring charge carrier lifetime in Si, which utilizes the carrier exchange interaction of Mu. The project, therefore, aims for future applications in a wide range of semiconductors. We recently manufactured a new mirror box for HIFI, which would enable us to pump samples from the same side as muons. This proposal would be the first user experiment to use it and provide a good opportunity for testing.
DOI: 10.5286/isis.e/isis.e.rb2420454
title: Crystal field excitations in the new pyrochlore compounds Nd2-xYbxTi2O7

description: This study investigates a novel approach to dilution or mixing of cations in pyrochlores, where the magnetic lattice site accommodates two rare-earth cations simultaneously. Specifically, the compounds Nd2-xYbxTi2O7 (x = 1.5, 1.0, 0.5) are explored, leveraging the distinct properties of Nd3+ and Yb3+ ions, including their Kramers-type nature and differing ionic radii sizes. This unique arrangement is anticipated to induce fundamental modifications in the crystalline electric field (CEF) levels. The primary objective is to elucidate the CEF levels of Nd2-xYbxTi2O7, potentially revealing a new energetic configuration resulting from the presence of two different cations with doublet ground states. Through this investigation, a precise understanding of the implications of Nd/Yb mixing on the magnetism of the pyrochlore Nd2-xYbxTi2O7 is sought, offering insights into complex phenomena or emergent magnetic ground states than can be expected in this series.
DOI: 10.5286/isis.e/isis.e.rb2420454-1
title: Crystal field excitations in the new pyrochlore compounds Nd2-xYbxTi2O7

description: This study investigates a novel approach to dilution or mixing of cations in pyrochlores, where the magnetic lattice site accommodates two rare-earth cations simultaneously. Specifically, the compounds Nd2-xYbxTi2O7 (x = 1.5, 1.0, 0.5) are explored, leveraging the distinct properties of Nd3+ and Yb3+ ions, including their Kramers-type nature and differing ionic radii sizes. This unique arrangement is anticipated to induce fundamental modifications in the crystalline electric field (CEF) levels. The primary objective is to elucidate the CEF levels of Nd2-xYbxTi2O7, potentially revealing a new energetic configuration resulting from the presence of two different cations with doublet ground states. Through this investigation, a precise understanding of the implications of Nd/Yb mixing on the magnetism of the pyrochlore Nd2-xYbxTi2O7 is sought, offering insights into complex phenomena or emergent magnetic ground states than can be expected in this series.
DOI: 10.34816/ifao.archives.232801
title: SAQQARA_nb_1994_06053

description: Référence : nb_1994_06053<br />Site : Saqqara<br />Secteur : Mastaba de Ti<br />Type : photographie<br />
DOI: 10.3535/wlt-dhs-3fd
title: Eragrostis multiflora Trin.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/ym6-q5b-0p9
title: Sporobolus R.Br.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.5286/isis.e/isis.e.rb2220739
title: Measuring absorption coefficient of Si using photoexcited muon spin spectroscopy

description: Here we propose a photoexcited muon spin spectroscopy experiment to measure absorption coefficient - a key parameter in optical/photovoltaic applications in semiconductor engineering. We plan to utilize the photo-uSR technique originally developed for measuring charge carrier lifetime in Si, which utilizes the carrier exchange interaction of Mu. The project, therefore, aims for future applications in a wide range of semiconductors. We recently manufactured a new mirror box for HIFI, which would enable us to pump samples from the same side as muons. This proposal would be the first user experiment to use it and provide a good opportunity for testing.
DOI: 10.5286/isis.e/isis.e.rb2410084-1
title: Neutron Diffraction Studies of Metal-Organic Frameworks for Ammonia Adsorption

description: Porous metal-organic frameworks (MOFs) are gaining increasing attention due to their recently commercialised application in gas adsorption. There is a strong interest in ammonia adsorption owing to the high volumetric and gravimetric hydrogen energy density of ammonia. We seek to develop MOF materials with exceptional ammonia capacity and request 4 days on WISH to study the preferred binding sites and orientation of adsorbed ND3 molecules in the MOFs. This proposed study will investigate the precise locations of ND3 and CO2 molecules within two robust MOFs, namely Al-BTA-1 and Al-BTA-2. These MOFs exhibit exceptionally high capacity for ammonia at extremely low concentration with repeatable cycles, representing the best-performing materials to date. The high resolution, low background and large d-spacing capabilities of WISH will enable structural insight to study the precise locations and preferred orientation of ND3 molecules. The proposed study aims to reveal the change in host-guest interaction with respect to different surface coverage.