cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.14277774
title: Performance of Severity Indices to Estimate Postoperative Complications of Myocardial Revascularization

description: Abstract Background Patients in the postoperative period of myocardial revascularization (Coronary Artery Bypass Grafting - CABG) surgery admitted to the intensive care unit (ICU) are at risk of complications which increase the length of stay and morbidity and mortality. Therefore, early recognition of these risks is essential to optimize prevention strategies and a satisfactory clinical outcome. Objective To analyze the performance of severity indices in predicting complications in patients in the postoperative of CABG during the ICU stay. Methods A cross-sectional study with retrospective analysis of electronic medical records of patients aged ≥ 18 years who underwent isolated CABG and were admitted to the ICU of a cardiology hospital in São Paulo, Brazil. The areas under the receiver operating characteristic curves (AUC) with a 95% confidence interval were analyzed to verify the accuracy of the European System for Cardiac Operative Risk Evaluation (EuroScore), Acute Physiology and Chronic Health Evaluation (APACHE II), Simplified Acute Physiology Score (SAPS II) and Sequential Organ Failure Assessment (SOFA) indices in predicting complications. Results The sample consisted of 366 patients (64.58 ± 9.42 years; 75.96% male). The complications identified were: respiratory (24.32%), cardiovascular (19.95%), neurological (10.38%), hematological (10.38%), infectious (6.56%) and renal (3.55%). APACHE II showed satisfactory performance for predicting neurological (AUC 0.72) and renal (AUC 0.78) complications. Conclusion APACHE II excelled in predicting neurological and renal complications. None of the indices performed well in predicting the other analyzed complications. Therefore, severity indices should not be used indiscriminately in order to predict all complications frequently presented by patients after CABG. (Arq Bras Cardiol. 2020; 115(3):452-459)
DOI: 10.6084/m9.figshare.21755426
title: Computational analysis of fusion protein of anti-HER2 scFv and alpha luffin: A new immunotoxin protein for HER2 positive cancers

description: Abstract The present study deals with the computational design and analysis of a novel fusion protein based on a single chain variable fragment that binds to the extracellular domain of human epidermal growth factor receptor 2 (HER2) in breast cancer cells. Alpha luffin, a small ribosome inactivating protein (RIP), was attached to the anti-HER2 antibody fragment. I-TASSER modeling provided the full-length structure of the fusion protein. Molecular docking evaluated the molecular interactions of the complementarity-determining regions of designed fusion protein to HER2. Energy minimization and molecular dynamics simulations were conducted to refine the complexes. RMSD plot revealed reasonable stability of the fusion protein during the simulation. The free binding energy profile of complexes affirmed a favorable binding affinity of proteins in complex with HER2 using molecular mechanics Poisson-Boltzmann surface area (G-MMPBSA) algorithm. In general, this approach looks promising in the development of new fusion proteins in terms of immunotoxins with appropriate cytotoxicity.
DOI: 10.6084/m9.figshare.21755426.v1
title: Computational analysis of fusion protein of anti-HER2 scFv and alpha luffin: A new immunotoxin protein for HER2 positive cancers

description: Abstract The present study deals with the computational design and analysis of a novel fusion protein based on a single chain variable fragment that binds to the extracellular domain of human epidermal growth factor receptor 2 (HER2) in breast cancer cells. Alpha luffin, a small ribosome inactivating protein (RIP), was attached to the anti-HER2 antibody fragment. I-TASSER modeling provided the full-length structure of the fusion protein. Molecular docking evaluated the molecular interactions of the complementarity-determining regions of designed fusion protein to HER2. Energy minimization and molecular dynamics simulations were conducted to refine the complexes. RMSD plot revealed reasonable stability of the fusion protein during the simulation. The free binding energy profile of complexes affirmed a favorable binding affinity of proteins in complex with HER2 using molecular mechanics Poisson-Boltzmann surface area (G-MMPBSA) algorithm. In general, this approach looks promising in the development of new fusion proteins in terms of immunotoxins with appropriate cytotoxicity.
DOI: 10.6084/m9.figshare.21744036
title: Causal Relations Signaled by the Connector porque [because]: Articulating functional-cognitive, and Interactional-discursive Perspectives

description: Abstract In this work, we study how the connector porque [because] acts in signaling causality in the last presidential debate of the 2018 Brazilian presidential campaign. The objective was to verify if the connector is characterized by multifunctionality, not only signaling a cause-and-effect relationship but introducing arguments to justify speech acts and support opinions, beliefs, and judgments expressed in the sentence to which it is connected. Understanding these roles required articulating two distinct but complementary theoretical perspectives: the cognitive-functional and the discursive-interactional. Analyzing the 89 occurrences of the connector, we show that the agonizing nature of the debate genre makes the majority of occurrences of causal sentences with porque allowing the performance of a wide range of speech acts and to supporting (explaining or justifying) beliefs or judgments expressed in the main constituent.
DOI: 10.6084/m9.figshare.21744036.v1
title: Causal Relations Signaled by the Connector porque [because]: Articulating functional-cognitive, and Interactional-discursive Perspectives

description: Abstract In this work, we study how the connector porque [because] acts in signaling causality in the last presidential debate of the 2018 Brazilian presidential campaign. The objective was to verify if the connector is characterized by multifunctionality, not only signaling a cause-and-effect relationship but introducing arguments to justify speech acts and support opinions, beliefs, and judgments expressed in the sentence to which it is connected. Understanding these roles required articulating two distinct but complementary theoretical perspectives: the cognitive-functional and the discursive-interactional. Analyzing the 89 occurrences of the connector, we show that the agonizing nature of the debate genre makes the majority of occurrences of causal sentences with porque allowing the performance of a wide range of speech acts and to supporting (explaining or justifying) beliefs or judgments expressed in the main constituent.
DOI: 10.5519/qd.ylftv1ie
title: Query on the Natural History Museum Data Portal (data.nhm.ac.uk) (16 records)
DOI: 10.6084/m9.figshare.21755432
title: Coronary Blood Flow Measurement in Conventional Coronary Angiograms by a New Method Based on Contrast Density Detection. A Physiological Insight

description: Abstract Background TIMI flow grade and corrected TIMI frame count (CTFC) are widely used methods to evaluate angiographic coronary blood flow. Measurement of coronary blood flow (CBF) on standard coronary angiography (CAG) has aroused great interest recently, trying to combine the CTFC concept with new methods for post-angioplasty and for cardiac syndrome X assessment. Additionally, coronary slow flow it is now considered a major criterion for microvascular angina. Objective Explore a new approach of quantitative angiographic measurement of CBF based on densitometric contrast detection in CAG off-line, using an accessible software to obtain a more precise and reliable CBF assessment. Methods Thirty patients were studied and divided in 2 groups, normal coronary blood flow (NF) and slow coronary blood flow (SF), according to CTFC definition. The DM was applied to the study sample to differentiate between NF and SF. Non-parametric statistics was used to assess differences between groups at p&lt;0.05. Results The DM normal reference value obtained for coronary blood flow was 9 [5–10] frames. NF vs SF group were compared and expressed as median [interquartile range], for the left anterior descending: 10 [7-11] vs 21 [8-33];p= 0.016; circumflex: 9 [4-13] vs 14 [11-30]; p= 0.012 and right coronary artery: 5 [3-11] vs 13 [8-26]; p=0.009. Conclusion The DM showed the feasibility of measuring coronary blood flow with precision, consistency and reproducible in a standard coronary angiogram, showing the additional capability to differentiate between NF and SF in chest pain patients with normal coronary arteries. (Arq Bras Cardiol. 2020; 115(3):503-512)
DOI: 10.6084/m9.figshare.21755432.v1
title: Coronary Blood Flow Measurement in Conventional Coronary Angiograms by a New Method Based on Contrast Density Detection. A Physiological Insight

description: Abstract Background TIMI flow grade and corrected TIMI frame count (CTFC) are widely used methods to evaluate angiographic coronary blood flow. Measurement of coronary blood flow (CBF) on standard coronary angiography (CAG) has aroused great interest recently, trying to combine the CTFC concept with new methods for post-angioplasty and for cardiac syndrome X assessment. Additionally, coronary slow flow it is now considered a major criterion for microvascular angina. Objective Explore a new approach of quantitative angiographic measurement of CBF based on densitometric contrast detection in CAG off-line, using an accessible software to obtain a more precise and reliable CBF assessment. Methods Thirty patients were studied and divided in 2 groups, normal coronary blood flow (NF) and slow coronary blood flow (SF), according to CTFC definition. The DM was applied to the study sample to differentiate between NF and SF. Non-parametric statistics was used to assess differences between groups at p&lt;0.05. Results The DM normal reference value obtained for coronary blood flow was 9 [5–10] frames. NF vs SF group were compared and expressed as median [interquartile range], for the left anterior descending: 10 [7-11] vs 21 [8-33];p= 0.016; circumflex: 9 [4-13] vs 14 [11-30]; p= 0.012 and right coronary artery: 5 [3-11] vs 13 [8-26]; p=0.009. Conclusion The DM showed the feasibility of measuring coronary blood flow with precision, consistency and reproducible in a standard coronary angiogram, showing the additional capability to differentiate between NF and SF in chest pain patients with normal coronary arteries. (Arq Bras Cardiol. 2020; 115(3):503-512)
DOI: 10.6084/m9.figshare.21639977
title: Corporations and the Brazilian civil-military dictatorship: the editorials of Folha de S. Paulo newspaper from a historical perspective

description: Abstract In alignment with historical organizational studies (Decker, Hassard, & Rowlinson, 2021; Maclean, Harvey, & Clegg, 2016) and seeking a geographical (re)orientation, more to the Global South, to historical research in organizational and management studies (A. S. M. Costa & Wanderley, 2021; Wanderley & A. Barros, 2019), the article aims to understand the ideological positioning and the political-discursive performance of the newspaper Folha de S. Paulo in the early period of the Brazilian civil-military dictatorship (1964-1985). A theoretical framework was built, supported by two historiographical currents (Business and Dictatorship; History and Press) and by the concepts of discourse, ideology, and power articulated by critical discourse analysis. In terms of documental sources, 112 daily editorials were collected, published from January to June 1964, and available in the historical archive of the researched company. The theoretical and methodological contribution of Norman Fairclough’s (2016) three-dimensional model and its proposed use by J.B. Thompson’s (2011) model of analysis of strategies of ideological constructions were used. As a result, it was possible to identify three different moments in the discursive trajectory of the positioning of the Folha de S. Paulo newspaper concerning the military coup of 1964 in Brazil: (1) significant contribution to the destabilization of the democratic government of President João Goulart, (2) strong alignment with the military coup and its immediate unfoldings; and (3) support for the subsequent Castelo Branco government, but already with the enunciation of some reservations. Finally, it is possible to affirm that this journalistic organization acted strongly not only as an instrument of information but mainly as a producer and reproducer of specific discourses in favor of a particular social group and its subsequent dictatorial acts. Against this background, historical research into the political and socio-economic relations between business, government, and society over time and their unfolding today is becoming increasingly necessary.
DOI: 10.6084/m9.figshare.21639977.v1
title: Corporations and the Brazilian civil-military dictatorship: the editorials of Folha de S. Paulo newspaper from a historical perspective

description: Abstract In alignment with historical organizational studies (Decker, Hassard, & Rowlinson, 2021; Maclean, Harvey, & Clegg, 2016) and seeking a geographical (re)orientation, more to the Global South, to historical research in organizational and management studies (A. S. M. Costa & Wanderley, 2021; Wanderley & A. Barros, 2019), the article aims to understand the ideological positioning and the political-discursive performance of the newspaper Folha de S. Paulo in the early period of the Brazilian civil-military dictatorship (1964-1985). A theoretical framework was built, supported by two historiographical currents (Business and Dictatorship; History and Press) and by the concepts of discourse, ideology, and power articulated by critical discourse analysis. In terms of documental sources, 112 daily editorials were collected, published from January to June 1964, and available in the historical archive of the researched company. The theoretical and methodological contribution of Norman Fairclough’s (2016) three-dimensional model and its proposed use by J.B. Thompson’s (2011) model of analysis of strategies of ideological constructions were used. As a result, it was possible to identify three different moments in the discursive trajectory of the positioning of the Folha de S. Paulo newspaper concerning the military coup of 1964 in Brazil: (1) significant contribution to the destabilization of the democratic government of President João Goulart, (2) strong alignment with the military coup and its immediate unfoldings; and (3) support for the subsequent Castelo Branco government, but already with the enunciation of some reservations. Finally, it is possible to affirm that this journalistic organization acted strongly not only as an instrument of information but mainly as a producer and reproducer of specific discourses in favor of a particular social group and its subsequent dictatorial acts. Against this background, historical research into the political and socio-economic relations between business, government, and society over time and their unfolding today is becoming increasingly necessary.
DOI: 10.6084/m9.figshare.21755435
title: APPLICATION OF ARTIFICIAL INTELLIGENCE FOR IRRIGATION MANAGEMENT: A SYSTEMATIC REVIEW

description: ABSTRACT A literature review on artificial intelligence in irrigation management was performed, using the Systematic Literature Review (SLR) method with explicit search criteria. More than 45,000 complete titles in 130 reference bases were consulted at once. A total of 38 primary studies were selected, which formed the basis of this review. The findings showed increasing use of Artificial Neural Networks (ANN) fed with climate and soil sensor data for irrigation management solutions. ANNs have been the most popular choice for solutions that require machine learning techniques. Fuzzy-logic-based technologies stood out in Decision Support Systems (SSD). Hybrid neuro-fuzzy approaches manage the best aspects contained in each of the two techniques (ANN and fuzzy logic). Moreover, autonomous wireless and networked sensors have been the most often used. Good chances of developing solutions for irrigation management point to the growing application of ANN-based machine learning, Support Vector Machine (SVM), and Random Forests techniques, using wireless sensor networks and computer vision with remote sensing images.
DOI: 10.6084/m9.figshare.21755435.v1
title: APPLICATION OF ARTIFICIAL INTELLIGENCE FOR IRRIGATION MANAGEMENT: A SYSTEMATIC REVIEW

description: ABSTRACT A literature review on artificial intelligence in irrigation management was performed, using the Systematic Literature Review (SLR) method with explicit search criteria. More than 45,000 complete titles in 130 reference bases were consulted at once. A total of 38 primary studies were selected, which formed the basis of this review. The findings showed increasing use of Artificial Neural Networks (ANN) fed with climate and soil sensor data for irrigation management solutions. ANNs have been the most popular choice for solutions that require machine learning techniques. Fuzzy-logic-based technologies stood out in Decision Support Systems (SSD). Hybrid neuro-fuzzy approaches manage the best aspects contained in each of the two techniques (ANN and fuzzy logic). Moreover, autonomous wireless and networked sensors have been the most often used. Good chances of developing solutions for irrigation management point to the growing application of ANN-based machine learning, Support Vector Machine (SVM), and Random Forests techniques, using wireless sensor networks and computer vision with remote sensing images.
DOI: 10.6084/m9.figshare.21755438.v1
title: Development of microsatellite panels for molecular fingerprinting of Napier grass (Cenchrus purpureus) cultivars

description: Abstract Napier grass is a perennial tropical forage that is used in beef and dairy production systems. Despite its significance in animal nutrition, molecular information available, such as microsatellite or simple sequence repeat (SSR) or single nucleotide polymorphism (SNP) markers, is limited. Using an assembled transcriptome, 50 novel SSR markers were developed, of which 21 were found to be polymorphic. These polymorphic markers were tested for DNA fingerprinting of Embrapa cultivars, five of which revealed distinct allele patterns for cultivar identification. SSR markers 05, 17, and 44 identified a unique pattern in the BRS Kurumi cultivar. The BRS Capiaçu cultivar was identified using SSR markers 17, 43, and 44. The Pioneiro cultivar exhibited a rare fragment amplification pattern using SSR marker 46, while SSR marker 44 revealed a distinct allele in the BRS Canará cultivar. SSR marker panels could be utilized as DNA fingerprinting tools to assist in cultivar identification.
DOI: 10.6084/m9.figshare.21755438
title: Development of microsatellite panels for molecular fingerprinting of Napier grass (Cenchrus purpureus) cultivars

description: Abstract Napier grass is a perennial tropical forage that is used in beef and dairy production systems. Despite its significance in animal nutrition, molecular information available, such as microsatellite or simple sequence repeat (SSR) or single nucleotide polymorphism (SNP) markers, is limited. Using an assembled transcriptome, 50 novel SSR markers were developed, of which 21 were found to be polymorphic. These polymorphic markers were tested for DNA fingerprinting of Embrapa cultivars, five of which revealed distinct allele patterns for cultivar identification. SSR markers 05, 17, and 44 identified a unique pattern in the BRS Kurumi cultivar. The BRS Capiaçu cultivar was identified using SSR markers 17, 43, and 44. The Pioneiro cultivar exhibited a rare fragment amplification pattern using SSR marker 46, while SSR marker 44 revealed a distinct allele in the BRS Canará cultivar. SSR marker panels could be utilized as DNA fingerprinting tools to assist in cultivar identification.
DOI: 10.6084/m9.figshare.21755441
title: COVID-19 AND THE INFLUENCE OF SOCIAL RESTRICTION ON PHYSICAL ACTIVITY AMONG CHILDREN AND ADOLESCENTS

description: ABSTRACT The objectives of this study were to verify the influence of the procedures adopted to contain the Covid-19 pandemic on the levels of physical activity (PA) of children and adolescents, as well as to check if there are any differences between the sexes and age groups. A quick literature review was carried out by means of a search in journals available in the PubMed, Scopus and Web of Science databases, using the following keywords: Children, Adolescents, Physical Exercise, Physical Activity, and Covid-19. Of the 449 studies identified, 17 were selected by the criterion of containing data referring to before and during the social restriction period in the same study. With the exception of one article, the synthesis of results indicated a decrease in PA levels and an increase in time spent on screen activities during the social restriction period, in greater proportions for adolescents and for females. Results are similar among countries in the same region than comparing different continents, due to differences in the sociocultural environment in which young people live, mainly encouraged by their guardians. From a public health point of view, there should be a concern about the continuity of this pattern of behavior after the end of the pandemic, which would further increase the risk of already existing problems, such as delays in motor development, overweight, obesity, cardiovascular diseases and diabetes in adulthood.
DOI: 10.6084/m9.figshare.21755441.v1
title: COVID-19 AND THE INFLUENCE OF SOCIAL RESTRICTION ON PHYSICAL ACTIVITY AMONG CHILDREN AND ADOLESCENTS

description: ABSTRACT The objectives of this study were to verify the influence of the procedures adopted to contain the Covid-19 pandemic on the levels of physical activity (PA) of children and adolescents, as well as to check if there are any differences between the sexes and age groups. A quick literature review was carried out by means of a search in journals available in the PubMed, Scopus and Web of Science databases, using the following keywords: Children, Adolescents, Physical Exercise, Physical Activity, and Covid-19. Of the 449 studies identified, 17 were selected by the criterion of containing data referring to before and during the social restriction period in the same study. With the exception of one article, the synthesis of results indicated a decrease in PA levels and an increase in time spent on screen activities during the social restriction period, in greater proportions for adolescents and for females. Results are similar among countries in the same region than comparing different continents, due to differences in the sociocultural environment in which young people live, mainly encouraged by their guardians. From a public health point of view, there should be a concern about the continuity of this pattern of behavior after the end of the pandemic, which would further increase the risk of already existing problems, such as delays in motor development, overweight, obesity, cardiovascular diseases and diabetes in adulthood.