DOI: 10.5061/dryad.20c5c
title: Data from:A computational study of cancer hyperthermia based on vascular magnetic nanoconstructs

description: The application of hyperthermia to cancer treatment is studied using a
 novel model arising from the fundamental principles of flow, mass and heat
 transport in biological tissues. The model is defined at the scale of the
 tumour microenvironment and an advanced computational scheme called the
 embedded multiscale method is adopted to solve the governing equations.
 More precisely, this approach involves modelling capillaries as
 one-dimensional channels carrying flow, and special mathematical operators
 are used to model their interaction with the surrounding tissue. The
 proposed computational scheme is used to analyse hyperthermic treatment of
 cancer based on systemically injected vascular magnetic nanoconstructs
 carrying super-paramagnetic iron oxide nanoparticles. An alternating
 magnetic field is used to excite the nanoconstructs and generate localized
 heat within the tissue. The proposed model is particularly adequate for
 this application, since it has a unique capability of incorporating
 microvasculature configurations based on physiological data combined with
 coupled capillary flow, interstitial filtration and heat transfer. A
 virtual tumour model is initialized and the spatio-temporal distribution
 of nanoconstructs in the vascular network is analysed. In particular, for
 a reference iron oxide concentration, temperature maps of several
 different hypothesized treatments are generated in the virtual tumour
 model. The observations of the current study might in future guide the
 design of more efficient treatments for cancer hyperthermia.
description: Cv_IONP_Injection_40minIONP particle injection, 40 min circulation time, particle concentration mapsCv.vtkTt_IONP_Injection_40minIONP particle injection, 40 min circulation time, temperature mapsTt.vtkTt_VMN_Injection_40minCirculationVMN particle injection, 40 min circulation time, temperature mapCt.vtkCv_VMN_Injection_40minCirculationVMN particle injection, 40 min circulation time, particle concentration mapCv.vtkPsi_VMN_Injection_40minCirculationVMN particle injection, 40 min circulation time, map of the particles adhering to the capillary wallsPsi.vtkTt_VMN_Injection_12hCirculationVMN particle injection, 12 hours circulation time, temperature mapCt.vtkCv_VMN_Injection_12hCirculationVMN particle injection, 12 hours circulation time, particle concentration mapCv.vtkPsi_VMN_Injection_12hCirculationVMN particle injection, 12 hours circulation time, map of the particles adhering to the capillary wallsPsi.vtkTt_VMN_Injection_24hCirculationVMN particle injection, 24 hours circulation time, temperature mapCt.vtkCv_VMN_Injection_24hCirculationVMN particle injection, 24 hours circulation time, particle concentration mapCv.vtkPsi_VMN_Injection_24hCirculationVMN particle injection, 24 hours circulation time, map of the particles adhering to the capillary wallsPsi.vtkTt_VMN_Injection_48hCirculationVMN particle injection, 48 hours circulation time, temperature mapCt.vtkCv_VMN_Injection_48hCirculationVMN particle injection, 48 hours circulation time, particle concentration mapCv.vtkPsi_VMN_Injection_48hCirculationVMN particle injection, 48 hours circulation time, map of the particles adhering to the capillary wallsPsi.vtk