cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.23791527
title: Supplementary Material for: Large Ascites in a Cirrhotic Patient Reveal an Isolated and Late Metastasis of Ductal Breast Cancer: Case Study

description: Breast cancer is the most prevalent cancer in women worldwide, and its prevalence has increased since the introduction of screening programs. Most cases are discovered at an early stage; however, despite effective treatment, some cases progress to metastasis. The most common breast cancer metastatic locations are the bone, liver, and lungs. Ascites malignant due to peritoneal involvement is a rare manifestation of metastatic breast cancer. After eight years of well-controlled breast cancer, we report a 54-year-old woman who presents with malignant ascites and is known to have cirrhosis of the liver.
DOI: 10.6084/m9.figshare.23898006
title: Supplementary Material for: Remitting seronegative symmetrical synovitis with pitting edema (RS3PE): A case report of an immune-related adverse event following surgery

description: Immune checkpoint inhibitors (ICIs) have emerged as a novel class of anti-neoplastic agent in oncology. Their integration into practice has been accompanied by “immune-related adverse events” (irAEs) wherein off-target immune responses damage healthy tissues. Severe irAEs can cause irreversible organ dysfunction and death. Despite this, little is known about factors which predispose certain patients to develop irAEs or which precipitate their onset. Here, we report a case of a patient with melanoma who completed adjuvant immunotherapy, underwent elective hip replacement, and developed a rare rheumatologic irAE (remitting seronegative symmetrical synovitis with pitting edema (RS3PE)) post-operatively. Mechanistically, we hypothesize that surgery contributed to irAE pathogenesis as a sensitizing event in which self-antigens were presented to an immune system with diminished peripheral tolerance in the context of recent ICI administration. This case highlights a need for future correlative analyses investigating whether iatrogenic interventions such as surgery might be associated with irAE development.
DOI: 10.6084/m9.figshare.23904918
title: Supplementary Material for: How could different obesity scenarios alter the burden of type 2 diabetes and liver disease in Saudi Arabia?

description: Introduction Obesity is a major risk factor for type 2 diabetes (T2DM) and liver disease, and obesity-attributable liver disease is a common indication for liver transplant. Obesity prevalence in Saudi Arabia (SA) has increased in recent decades. SA has committed to the WHO ‘halt obesity’ target to shift prevalence to 2010 levels by 2025. We estimated the future benefits of reducing obesity in SA on incidence and costs of T2DM and liver disease under two policy scenarios: 1) SA meets the ‘halt obesity’ target; 2) population body mass index (BMI) is reduced by 1% annually from 2020 to 2040. Methods We developed a dynamic microsimulation of working-age people (20-59 years) in SA between 2010 and 2040. Model inputs included population demographic, disease and healthcare cost data, and relative risks of diseases associated with obesity. In our two policy scenarios, we manipulated population BMI and compared predicted disease incidence and associated healthcare costs to a baseline ‘no change’ scenario. Results Adults &lt;35 years are expected to meet the ‘halt obesity’ target, but those ≥35 years are not. Obesity is set to decline for females, but to increase amongst males 35-59 years. If SA’s working-age population achieved either scenario, &gt;1.15 million combined cases of T2DM, liver disease and liver cancer could be avoided by 2040. Healthcare cost savings for the ‘halt obesity’ and 1% reduction scenarios are 46.7 and 32.8 billion USD, respectively. Discussion/Conclusion SA’s younger working-age population is set to meet the ‘halt obesity’ target, but those aged 35-59 are off-track. Even a modest annual 1% BMI reduction could result in substantial future health and economic benefits. Our findings strongly support universal initiatives to reduce population-level obesity, with targeted initiatives for working-age people ≥35 years of age.
DOI: 10.6084/m9.figshare.24031914
title: Supplementary Material for: Scleroderma Secondary to Pembrolizumab: A Case Report and Review of 19 cases of anti PD-1-induced scleroderma.

description: Immune checkpoint inhibitors are increasingly being used to treat various malignancies. They are known to potentially cause immune-related adverse effects, including dermatological manifestations. A rare cutaneous immune-related adverse effect is scleroderma, which has been reported to occur with anti-programmed cell death-1 (PD-1) agents such as pembrolizumab and nivolumab. This may present with skin tightening and hardening at any point during or after immunotherapy. We present the case of a 54-year-old Caucasian woman who, following 16 cycles of Pembrolizumab for breast cancer, developed clinical features of scleroderma confirmed on histology. She was initially treated with oral corticosteroids, followed by oral psoralen-UVA (PUVA), with poor response, but eventually improved with methotrexate. A literature review revealed 12 other cases of scleroderma following pembrolizumab treatment and 6 cases of scleroderma following nivolumab treatment . Scleroderma developed at different stages of pembrolizumab therapy. Although scleroderma is not commonly drug-induced, pembrolizumab and nivolumab may be a rare causes and it is important to elicit an accurate drug history, including immunotherapy, in such cases.
DOI: 10.6084/m9.figshare.24057096
title: Supplementary Material for: Risk of Hospital-Acquired Acute Kidney Injury among Adult Opioid Analgesic Users: A Multicenter Real-World Data Analysis

description: Introduction: Comprehensive data on the risk of hospital-acquired (HA) acute kidney injury (AKI) among adult users of opioid analgesics are lacking. This study aimed to systematically compare the risk of HA-AKI among the users of various opioid analgesics. Methods: This multicenter, retrospective real-world study analyzed 255265 adult hospitalized patients who received at least one prescription of opioid analgesic during the ﬁrst 30 days of hospitalization. Primary outcome was the time from the first opioid analgesic prescription to HA-AKI occurrence. 12 subtypes of opioid analgesics were analyzed, including 9 for treating moderate-to-severe pain and 3 for mild-to-moderate pain. We examined the association between the exposure to each subtype of opioid analgesic and the risk of HA-AKI using Cox proportional hazards models, using the most commonly used opioid analgesic as the reference group. Results: As compared to dezocine, the most commonly used opioid analgesic treating moderate-to-severe pain, exposure to morphine, but not the other 7 types of opioid analgesics, was associated with a significantly increased risk of HA-AKI (adjusted hazard ratio 1.56, 95% confidence interval [CI] 1.40–1.78). The association was consistent in stratified analyses and in a propensity-matched cohort. There were no significant differences in the risk of HA-AKI among the opioid analgesics users with mild-to-moderate pain after adjusting for confounders. Conclusion: The use of morphine was associated with an increased risk of HA-AKI in adult patients with moderate-to-severe pain. Opioid analgesics other than morphine should be chosen preferentially in adult patients with high risk of HA-AKI when treating moderate-to-severe pain.
DOI: 10.6084/m9.figshare.24064107
title: Supplementary Material for: Consumption of Sugar-sweetened Soft Drinks and Risk of Gastrointestinal Cancer: A Systematic Review and Meta-analysis of Observational Studies

description: Introduction: Previous observational studies have reported inconsistent findings on the association between consumption of sugar-sweetened soft drinks (SSSDs) and the risk of gastrointestinal (GI) cancer. This study investigated the associations between SSSD consumption and the risk of GI cancer using a systematic review and meta-analysis. Methods: Observational epidemiological studies were searched from the PubMed and EMBASE databases until June 2021. We conducted a meta-analysis of all included studies and subgroup meta-analyses based on various factors. Results: In a meta-analysis of 27 studies with nine case-control studies and 18 cohort studies, the consumption of SSSDs was modestly associated with an increased risk of GI cancer (OR/RR: 1.08; 95% CI, 1.01-1.16), with a significant positive dose-response relationship. In the subgroup meta-analysis by study design, there was a significant positive association between the consumption of SSSDs and GI cancer in cohort studies (RR, 1.11; 95% CI, 1.03-1.20; n = 18), but not in case-control studies. In the subgroup meta-analysis by type of cancer, consumption of SSSDs was significantly associated with an increased risk of colorectal cancer (OR/RR: 1.13; 95% CI, 1.07-1.19). Conclusions: This meta-analysis suggests that SSSD consumption significantly increases the risk of GI cancer, specifically colorectal cancer.
DOI: 10.6084/m9.figshare.24235144
title: Supplementary Material for: Case Report: Sorafenib-induced Capillary Leak Syndrome

description: Capillary leak syndrome is a rare life-threatening disorder of acute endothelial hyperpermeability. It consists of initial fluid extravasation resulting in hypotension, hypoalbuminemia and hemoconcentration, followed by noncardiogenic pulmonary edema from rapid fluid remobilization into intravascular compartment. Drug-induced etiology is an important diagnostic consideration in cancer patients, particularly with use of antimetabolites, immunostimulants and monoclonal antibodies. Sorafenib-mediated capillary leak syndrome has never been reported. Here, we present the case of a 29-year-old female patient with a desmoid tumor of the thigh, who was admitted for acute hypoxic respiratory failure after recent initiation of sorafenib. She was found to have extensive pulmonary edema, bilateral pleural effusions, and hemoconcentration, all of which stabilized on supportive care with non-invasive mechanical ventilation and intravenous diuresis. Her infectious and cardiac work-up were negative. Given the temporal relationship between sorafenib use and symptom onset as well as a lack of an alternative etiology of her findings, patient was deemed to have sorafenib-induced acute capillary leak syndrome. Importantly, she did not become hypotensive prior to or during this hospitalization. To our knowledge, we reported for the first time an atypical presentation of acute capillary leak syndrome due to sorafenib use without hemodynamic instability.
DOI: 10.5281/zenodo.8370556
title: Data from: Direct contribution of invertebrate holobionts to methane release from coastal sediments

description: In this study, we incubated 103 animals specimens equivalent to 19 macrofaunal species to quantify holobiont-associated methane (CH<sub>4</sub>) fluxes and metabolic processes [oxygen (O<sub>2</sub>) - respiration and ammonium (NH<sub>4</sub><sup>+</sup>) - excretion rates]. The specific goals were to quantify holobionts CH<sub>4</sub> production/uptake and to establish correlations between CH<sub>4</sub> fluxes and environmental factors (e.g., salinity). Invertebrates were collected in 4 coastal systems and incubated in 22 mL glass microcosms filled with 0.22 µm twice-filtered <em>in situ</em> water. Individual and Mass-standardized CH<sub>4</sub> Production Rates (IPR and MPR, respectively), O<sub>2</sub> Respiration Rates (IRR and MRR) and NH<sub>4</sub><sup>+ </sup>Excretion Rates (IER and MER) were measured in 103 animals’ incubations. 1. IRR were calculated from linear regression analysis of the solute (O<sub>2</sub>) versus time equation: \(IRR=(Reg.Slope × V)/N\) <em> where IRR (µmol O<sub>2</sub> ind.<sup>−1</sup> day<sup>−1</sup>) is the respiration of the chemical species O<sub>2</sub>; Reg.Slope is the slope of the regression (µmol O<sub>2</sub> L<sup>−1</sup> day<sup>−1</sup>); V (L) is the water volume in the glass microcosm; N is the number of incubated animals per microcosm.</em> 2. IER and IPR were calculated from the difference in concentrations (NH<sub>4</sub><sup>+</sup> and CH<sub>4</sub>) in the water using the equation: \(IER and IPR = ((C_f-C_i )×V)/(N×t)\) <em> where IER and IPR (µmol ind.<sup>−1</sup> day<sup>−1</sup> and nmol ind.<sup>−1</sup> day<sup>−1</sup>) are the excretion or production of the chemical species (NH<sub>4</sub><sup>+</sup> or CH<sub>4</sub>); C<sub>f</sub> and C<sub>i</sub> (µmol or nmol L<sup>−1</sup>) are the final and initial concentrations of the chemical species; V (L) is the water volume in the glass microcosm; N is the number of incubated animals per microcosm; and t (days) is the incubation time. Positive values represent productions while negative values represent uptake.</em> Same equations were used to calculated mass-standardized rates, but instead of <em>N</em> the total animal biomass (g<sub>dw</sub>) was used. Animals’ biomass was determined as dry weight (DW) or as dry weight shell free (DWSF) for bivalves, after the desiccation at 70°C until constant mass. Water temperature and salinity were measured in situ with a multiple probe (556 MPS, YSI). Rates are reported as average ± standard error.
description: This work was supported financially by project INBALANCE funded by the European Social Fund (Grant No. 09.3.3-LMT-K-712-01-0069). Stefano Bonaglia was additionally supported by the Swedish Research Council Formas (Grants No. 2017-01513 and No. 2022-00546).
DOI: 10.6084/m9.figshare.23904930
title: Supplementary Material for: Finerenone in Patients with Chronic Kidney Disease and Type 2 Diabetes: FIDELIO-DKD subgroup from China

description: Background: This prespecified subgroup analysis of the FIDELIO-DKD trial aimed to evaluate the efficacy and safety of finerenone in patients with chronic kidney disease (CKD) and type 2 diabetes mellitus (T2DM) in China. Methods: Three hundred and seventy-two participants were recruited from 67 centers in China and randomized 1:1 to oral finerenone or placebo with standard therapy for T2DM. The primary composite outcome included kidney failure, sustained decrease of estimated glomerular filtration rate (eGFR) ≥ 40% from baseline over at least 4 weeks, or renal death. The key secondary composite outcome included death from cardiovascular causes, nonfatal myocardial infarction, nonfatal stroke, or hospitalization for heart failure. Results: After a median follow-up of 30 months, the finerenone group showed a relative risk reduction (RRR) of 41% (hazard ratio [HR]=0.59, 95% confidence interval [CI], 0.39 to 0.88; p=0.009) for the primary composite outcome compared with placebo, consistent across its components with treatment benefits with finerenone. Based on an absolute between-group difference of 12.2% after 30 months, the number of patients who needed to be treated (NNT) with finerenone to prevent one primary outcome event was eight (95%CI: 4 to 84). For the key secondary composite outcome, the finerenone group showed a RRR of 25% (HR=0.75, 95% CI, 0.38 to 1.48; p=0.408). Adverse events were similar between the two groups. The effects of finerenone on blood pressure were modest. No gynecomastia events were reported in the study. Hyperkalemia leading to discontinuation occurred in eight (4.3%) and two (1.1%) participants in the finerenone and control groups, respectively. The incidence of acute kidney injury was comparable between the two groups (1.6% vs. 1.6%). Conclusions: Finerenone resulted in lower risks of CKD progression than placebo and a balanced safety profile in Chinese patients with CKD and T2DM.
DOI: 10.6084/m9.figshare.23909547
title: Supplementary Material for: The impact of thrombocytopenia and lymphopenia on mortality in patients infected with Influenza virus – a retrospective cohort study

description: Introduction Influenza virus causes significant global annual morbidity and mortality. Thrombocytopenia is recognized as a poor prognostic factor in sepsis and is associated with mortality, while lymphopenia has been established as a poor prognostic factor in other viral infections. We aimed to assess the incidence of thrombocytopenia and lymphopenia in seasonal influenza and their effect on clinical outcomes. Methods This single-center, retrospective, cohort study included consecutive adult patients, hospitalized in Rabin Medical Center between October 2017 - April 2018, with laboratory confirmed influenza. Patients were grouped according to blood counts on admission: 1. Thrombocytopenia (&lt;150 K/ml), 2. lymphopenia (&lt;0.5K/ml), and 3. both thrombocytopenia and lymphopenia. Patients without thrombocytopenia and lymphopenia were designated as controls. The primary outcome was 30-days all-cause mortality. Risk factors were identified by univariable and multivariable analyses, using logistic regression and reported as odds ratios (OR) and 95% confidence intervals (CI). Results A total of 625 patients were included, 112 (18%) had thrombocytopenia, 98 (15.6%) had lymphopenia and 107 (17%) had both. The crude 30-days all-cause mortality was 7.6% (48/625). Mortality rates were 7.1% (8/112) for the thrombocytopenia group, 11.2% (11/98) for the lymphopenia group, and 14.9% (16/107) for patients with both vs 4.2% (13/308) in the control (p=0.000 for all). In a multivariable regression model, significant thrombocytopenia (&lt;100 K/microL) [OR 5.07, (95% CI 1.5-16.2)[, age [OR 1.07, (95% CI 1.02-1.11)], time to oseltamivir ]OR 1.006, (95%1.002-1.11)], and significant respiratory support [OR 8.85, (3.4-22.6)], were associated with 30-day all-cause mortality. Conclusion Patients hospitalized with seasonal influenza and thrombocytopenia &lt; 100K/mL on admission, have an increased 30-days all-cause mortality.
DOI: 10.7942/320620140320
title: P16S 2014

description: Oceanographic Survey
DOI: 10.25345/c5t43jd1z
title: MassIVE MSV000093100 - [SYPHU-SongLab] The Dataset of eudesmane-type sesquiterpenes from the daphne genus
title: The datasets for the eudesmane-type sesquiterpenes from the daphne genus. To support the further studies of plants of daphne genus.
DOI: 10.1285/i20380313v35p1
title: Frontespizio e pagine iniziali
DOI: 10.1285/i20380313v35p3
title: Sommario
DOI: 10.1285/i20380313v35p7
title: Foto
DOI: 10.5285/b80870de014a43a498fc2684e78f32af
title: Retrieved sulfur dioxide column amounts and heights from the IASI instrument (9-30 April 2021) v1.0

description: This dataset contains retrievals of sulfur dioxide (SO2) from the Infrared Atmospheric Sounding Interferometer (IASI) on the MetOp platforms. This is a global dataset for 9-30th April 2021 which includes plumes from La Soufrière (St Vincent), Sabancaya (Peru) and Sangay (Ecuador). Two retrieval schemes have been used: (1) Walker et al. (2011,2012) linear retrieval which flags pixels containing SO2 and (2) Carboni et al. (2012,2016) iterative retrieval which quantifies information about the SO2 including the column amount, height and the associated errors. The retrieved outputs are provided for individual IASI orbits. This dataset was used to study the large plume of SO2 from the April 2021 eruption of La Soufrière on St Vincent in the Eastern Caribbean. The data has been produced by the Earth Observation Data Group at the University of Oxford, as part of the NERC Centre for the Observation and Modelling of Earthquakes, Volcanoes and Tectonics (COMET).
DOI: 10.1285/i20380313v35p11
title: Presentazione
DOI: 10.1285/i20380313v35p13
title: PRIMA SEZIONE - Il contesto storico e la letteratura
DOI: 10.1285/i20380313v35p15
title: Il mondo attorno a Cosimo De Giorgi. La scienza nella Puglia della Belle Époque

description: Starting from Cosimo De Giorgi's broad scientific interest, this contribution aims to offer a mapping of belle époque science in Apulia. The purpose is to describe the world that surrounded De Giorgi, a world with which he was in constant and fruitful intellectual interaction. After giving a glance to the most important scientific disciplines developed in Apulia during that period, particular attention is paid to the field of agronomy. This issue is examined through a case study that shows the interactions between De Giorgi and other local agronomists, such as Achille Bruni, who was committed to promote the growth of new crops in the area. In conclusion, it is highlighted how knowledge in transit in Apulia was finally channelled in the foundation of the University of Bari.
description: Partendo dal poliedrico interesse scientifico di Cosimo De Giorgi, il presente contributo intende fornire una cartografia della scienza pugliese nella belle époque. L'obiettivo è di osservare il mondo che letteralmente circondava De Giorgi, un mondo con cui il lizzanellese era in costante e proficuo scambio intellettuale. Pur gettando un vasto sguardo alle più importanti discipline scientifiche in piena evoluzione in Puglia, particolare attenzione è riservata all'ambito agronomico, attraverso cui viene approfondito un caso di studio che mostra le interazioni tra De Giorgi e altri agronomi locali come Achille Bruni, intento a promuovere lo sviluppo di nuove culture sul territorio. In conclusione, si evidenzia come i saperi in transizione che animavano la vivacità scientifica dei pugliesi vennero canalizzati nell'istituzione dell'Università di Bari.
DOI: 10.1285/i20380313v35p45
title: Cosimo De Giorgi tra positivismo e bozzettismo

description: De Giorgi represents the figure of the scholar of his time, engaged in many aspects of knowledge: the natural sciences, history, geography. He did not want to renounce to follow, as far as possible, the various paths of knowledge, animated, moreover, not only by the scientific spirit, but also by the strong awareness of the civil value of his commitment: he intended to contribute to the improvement of the conditions of the society in which lived.
description: Cosimo De Giorgi incarna la figura dello studioso della sua epoca, impegnato su molti versanti del sapere: le scienze naturali, la storia, la geografia. Non ha voluto rinunciare a percorrere, per quanto gli era possibile, le diverse vie della conoscenza, animato, peraltro, oltre che dallo spirito scientifico, dalla forte coscienza del valore civile del suo impegno: egli intendeva contribuire al miglioramento delle condizioni della società in cui viveva.
DOI: 10.1285/i20380313v35p53
title: Cosimo De Giorgi e gli albori della Storia dell'Arte salentina

description: The essay focuses on the dawn of Salento art history, identifying Cosimo De Giorgi as the pioneer of sector studies, by method and by purpose. De Giorgi, however, anticipating the concept of "cultural heritage" by about a century, indicates the direction that must be followed methodologically for the conservation and protection of works of art, not separated from the maintenance of their memory, which can only be implemented through correct knowledge.
description: Il saggio mette a fuoco gli albori della Storia dell'Arte salentina, individuando in Cosimo De Giorgi il pioniere degli studi di settore, per metodo e per finalità. De Giorgi, peraltro, anticipando di circa un secolo il concetto di "bene culturale", indica la direzione che occorre seguire metodologicamente per la conservazione e la tutela delle opere d'arte, non disgiunte dalla manutenzione della loro memoria, che può essere attuata soltanto mediante una corretta conoscenza.
DOI: 10.6084/m9.figshare.24271744
title: 2023-01-01101B_additional_source_data

description: Additional source data for Main Figures and Extended Data.