cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.3422941
title: Mapping and ablation procedures for the treatment of ventricular tachycardia

description: <b>Introduction:</b> Ventricular tachycardia (VT) may occur in the presence or absence of structural heart disease. Given that the management of VT hinges on the presence of symptoms and risk of sudden cardiac death (SCD), the main treatment goals are elimination of symptoms (including frequent implantable cardioverter defibrillator [ICD] therapies) and prevention of SCD. Unfortunately, medical management is suboptimal in a significant proportion of patients. As such, ablative therapy plays a prominent role in the treatment of ventricular tachycardia. <b>Areas covered:</b> In this review, we will discuss various VT disorders that are encountered in patients with and without structural heart disease. Further, we will highlight salient features regarding mapping and ablation of the various VT syndromes. Finally, we will discuss what lies on the horizon for VT ablation. <b>Expert commentary:</b> Meticulous mapping should aim to find the region that is most likely to be successful and least likely to result in a complication. Although recognition of the various mechanisms of VT, familiarity with different methods to mapping and ablation, and awareness of potential limitations of current approaches is critical, a thorough understanding of the fundamental principles and nuances of each facet within EP is required to ensure optimal outcomes for our patients.
DOI: 10.6084/m9.figshare.3422941.v2
title: Mapping and ablation procedures for the treatment of ventricular tachycardia

description: <b>Introduction:</b> Ventricular tachycardia (VT) may occur in the presence or absence of structural heart disease. Given that the management of VT hinges on the presence of symptoms and risk of sudden cardiac death (SCD), the main treatment goals are elimination of symptoms (including frequent implantable cardioverter defibrillator [ICD] therapies) and prevention of SCD. Unfortunately, medical management is suboptimal in a significant proportion of patients. As such, ablative therapy plays a prominent role in the treatment of ventricular tachycardia. <b>Areas covered:</b> In this review, we will discuss various VT disorders that are encountered in patients with and without structural heart disease. Further, we will highlight salient features regarding mapping and ablation of the various VT syndromes. Finally, we will discuss what lies on the horizon for VT ablation. <b>Expert commentary:</b> Meticulous mapping should aim to find the region that is most likely to be successful and least likely to result in a complication. Although recognition of the various mechanisms of VT, familiarity with different methods to mapping and ablation, and awareness of potential limitations of current approaches is critical, a thorough understanding of the fundamental principles and nuances of each facet within EP is required to ensure optimal outcomes for our patients.
DOI: 10.6084/m9.figshare.3422932
title: Influence of hydrothermal treatment on the microstructure and oxidation resistance of a Zn<sub>4</sub>B<sub>2</sub>O<sub>7</sub>·H<sub>2</sub>O (4ZnO·B<sub>2</sub>O<sub>3</sub>·H<sub>2</sub>O) coating for C/C composites

description: Antioxidant modification for C/C composites by <i>in situ</i> hydrothermal synthesise at 140 °C of a 4ZnO·B<sub>2</sub>O<sub>3</sub>·H<sub>2</sub>O crystallite coating has been successfully achieved. The influence of hydrothermal time on the phase composition, microstructure of the as-prepared Zn<sub>4</sub>B<sub>2</sub>O<sub>7</sub>·H<sub>2</sub>O (4ZnO·B<sub>2</sub>O<sub>3</sub>·H<sub>2</sub>O), and its antioxidant modification for C/C composites were investigated. Samples were characterised by XRD, SEM, isothermal oxidation test and TG-DSC. Results show that, 4ZnO·B<sub>2</sub>O<sub>3</sub>·H<sub>2</sub>O crystalline coating is achieved on the surface of C/C composites after the hydrothermal treatment at 140 °C for time in the range of 2–12 h. A smooth and crack-free 4ZnO·B<sub>2</sub>O<sub>3</sub>·H<sub>2</sub>O layer can be obtained when the hydrothermal time reaches 8 h. Isothermal oxidation test demonstrates that the oxidation resistance of C/C composites is improved. The as-modified composites exhibit only 1.52 g·cm<sup>−2</sup> weight loss after oxidation at 600 °C for 15 h, while the non-modified one shows a 6.57 g·cm<sup>−2</sup> weight loss after only 10 h oxidation. For the uncoated C/C composite the oxidation rate is approximately linear with time (non-protective oxidation), thus at 15 h exposure one can estimate the mass loss to be 6.57 g·cm<sup>−2</sup> after 10 h for direct comparison with the coated samples.
DOI: 10.6084/m9.figshare.3422932.v1
title: Influence of hydrothermal treatment on the microstructure and oxidation resistance of a Zn<sub>4</sub>B<sub>2</sub>O<sub>7</sub>·H<sub>2</sub>O (4ZnO·B<sub>2</sub>O<sub>3</sub>·H<sub>2</sub>O) coating for C/C composites

description: Antioxidant modification for C/C composites by <i>in situ</i> hydrothermal synthesise at 140 °C of a 4ZnO·B<sub>2</sub>O<sub>3</sub>·H<sub>2</sub>O crystallite coating has been successfully achieved. The influence of hydrothermal time on the phase composition, microstructure of the as-prepared Zn<sub>4</sub>B<sub>2</sub>O<sub>7</sub>·H<sub>2</sub>O (4ZnO·B<sub>2</sub>O<sub>3</sub>·H<sub>2</sub>O), and its antioxidant modification for C/C composites were investigated. Samples were characterised by XRD, SEM, isothermal oxidation test and TG-DSC. Results show that, 4ZnO·B<sub>2</sub>O<sub>3</sub>·H<sub>2</sub>O crystalline coating is achieved on the surface of C/C composites after the hydrothermal treatment at 140 °C for time in the range of 2–12 h. A smooth and crack-free 4ZnO·B<sub>2</sub>O<sub>3</sub>·H<sub>2</sub>O layer can be obtained when the hydrothermal time reaches 8 h. Isothermal oxidation test demonstrates that the oxidation resistance of C/C composites is improved. The as-modified composites exhibit only 1.52 g·cm<sup>−2</sup> weight loss after oxidation at 600 °C for 15 h, while the non-modified one shows a 6.57 g·cm<sup>−2</sup> weight loss after only 10 h oxidation. For the uncoated C/C composite the oxidation rate is approximately linear with time (non-protective oxidation), thus at 15 h exposure one can estimate the mass loss to be 6.57 g·cm<sup>−2</sup> after 10 h for direct comparison with the coated samples.
DOI: 10.6084/m9.figshare.3422917
title: The leishmanicidal activity of oleuropein

description: Different datasets on which the conclusions of the manuscript rely.
DOI: 10.6084/m9.figshare.3422917.v1
title: The leishmanicidal activity of oleuropein

description: Different datasets on which the conclusions of the manuscript rely.
DOI: 10.6084/m9.figshare.3422905
title: OpenZika: An IBM World Community Grid Project to Accelerate Zika Virus Drug Discovery

description: A preprint of an article submitted to a journal - The Zika virus outbreak in the Americas has caused global concern, and to help this fight against Zika we launched the OpenZika project. OpenZika is an IBM World Community Grid Project that uses distributed computing on millions of computers and Android devices to run docking experiments, in order to dock millions of drug-like compounds against crystal structures and homology models of Zika proteins (and other related flavivirus targets). This will enable the identification of new virtual candidates that can then be tested <i>in vitro</i>, to advance the discovery and development of new antiviral drugs against the Zika virus. The docking data will be made openly accessible so that all members of the global research community can use it to further advance drug discovery studies for Zika and other viruses. <br>
DOI: 10.6084/m9.figshare.3422905.v2
title: OpenZika: An IBM World Community Grid Project to Accelerate Zika Virus Drug Discovery

description: A preprint of an article submitted to a journal - The Zika virus outbreak in the Americas has caused global concern, and to help this fight against Zika we launched the OpenZika project. OpenZika is an IBM World Community Grid Project that uses distributed computing on millions of computers and Android devices to run docking experiments, in order to dock millions of drug-like compounds against crystal structures and homology models of Zika proteins (and other related flavivirus targets). This will enable the identification of new virtual candidates that can then be tested <i>in vitro</i>, to advance the discovery and development of new antiviral drugs against the Zika virus. The docking data will be made openly accessible so that all members of the global research community can use it to further advance drug discovery studies for Zika and other viruses. <br>
DOI: 10.6084/m9.figshare.3422905.v1
title: OpenZika: An IBM World Community Grid Project to Accelerate Zika Virus Drug Discovery

description: A preprint of an article submitted to a journal - The Zika virus outbreak in the Americas has caused global concern, and to help this fight against Zika we launched the OpenZika project. OpenZika is an IBM World Community Grid Project that uses distributed computing on millions of computers and Android devices to run docking experiments, in order to dock millions of drug-like compounds against crystal structures and homology models of Zika proteins (and other related flavivirus targets). This will enable the identification of new virtual candidates that can then be tested <i>in vitro</i>, to advance the discovery and development of new antiviral drugs against the Zika virus. The docking data will be made openly accessible so that all members of the global research community can use it to further advance drug discovery studies for Zika and other viruses. <br>
DOI: 10.6084/m9.figshare.3422812
title: Understanding soot particle size evolution in laminar ethylene/air diffusion flames using novel soot coalescence models

description: Two coalescence models based on different merging mechanisms are introduced. The effects of the soot coalescence process on soot particle diameter predictions are studied using a detailed sectional aerosol dynamic model. The models are applied to a laminar ethylene/air diffusion flame, and comparisons are made with experimental data to validate the models. The implementation of coalescence models significantly improves the agreement of prediction of particle diameters with the experimental data. Sensitivity of the soot prediction to the coalescence parameters is analysed. Finally, an update to the coalescence model based on experimental observations of soot particles in the flame oxidation regions has been introduced to improve its predicting capabilities.
DOI: 10.6084/m9.figshare.3422812.v1
title: Understanding soot particle size evolution in laminar ethylene/air diffusion flames using novel soot coalescence models

description: Two coalescence models based on different merging mechanisms are introduced. The effects of the soot coalescence process on soot particle diameter predictions are studied using a detailed sectional aerosol dynamic model. The models are applied to a laminar ethylene/air diffusion flame, and comparisons are made with experimental data to validate the models. The implementation of coalescence models significantly improves the agreement of prediction of particle diameters with the experimental data. Sensitivity of the soot prediction to the coalescence parameters is analysed. Finally, an update to the coalescence model based on experimental observations of soot particles in the flame oxidation regions has been introduced to improve its predicting capabilities.
DOI: 10.6084/m9.figshare.3422809
title: Stratified Gaussian graphical models

description: Gaussian graphical models represent the backbone of the statistical toolbox for analyzing continuous multivariate systems. However, due to the intrinsic properties of the multivariate normal distribution, use of this model family may hide certain forms of context-specific independence that are natural to consider from an applied perspective. Such independencies have been earlier introduced to generalize discrete graphical models and Bayesian networks into more flexible model families. Here, we adapt the idea of context-specific independence to Gaussian graphical models by introducing a stratification of the Euclidean space such that a conditional independence may hold in certain segments but be absent elsewhere. It is shown that the stratified models define a curved exponential family, which retains considerable tractability for parameter estimation and model selection.
DOI: 10.6084/m9.figshare.3422809.v2
title: Stratified Gaussian graphical models

description: Gaussian graphical models represent the backbone of the statistical toolbox for analyzing continuous multivariate systems. However, due to the intrinsic properties of the multivariate normal distribution, use of this model family may hide certain forms of context-specific independence that are natural to consider from an applied perspective. Such independencies have been earlier introduced to generalize discrete graphical models and Bayesian networks into more flexible model families. Here, we adapt the idea of context-specific independence to Gaussian graphical models by introducing a stratification of the Euclidean space such that a conditional independence may hold in certain segments but be absent elsewhere. It is shown that the stratified models define a curved exponential family, which retains considerable tractability for parameter estimation and model selection.
DOI: 10.6084/m9.figshare.3422809.v1
title: Stratified Gaussian Graphical Models

description: Gaussian graphical models represent the backbone of the statistical toolbox for analyzing continuous multivariate systems. However, due to the intrinsic properties of the multivariate normal distribution, use of this model family may hide certain forms of context-specific independence that are natural to consider from an applied perspective. Such independencies have been earlier introduced to generalize discrete graphical models and Bayesian networks into more flexible model families. Here we adapt the idea of context-specific independence to Gaussian graphical models by introducing a stratification of the Euclidean space such that a conditional independence may hold in certain segments but be absent elsewhere. It is shown that the stratified models define a curved exponential family, which retains considerable tractability for parameter estimation and model selection.
DOI: 10.6084/m9.figshare.3422788
title: hSSB1-ssDNA structural model (lowest energy)

description: PDB coordinates of a molecular model of a complex between the protein hSSB1 and single-stranded DNA (ssDNA)<br><br>if used please cite:<br>------------------------<br>Christine Touma, Ruvini Kariawasam, Adrian X. Gimenez, Ray E. Bernardo, Nicholas W. Ashton, Mark N. Adams, Nicolas Paquet, Tristan I. Croll, Kenneth J. O’Byrne, Derek J. Richard, Liza Cubeddu and Roland Gamsjaeger (2016); A structural analysis of DNA binding by hSSB1 (NABP2/OBFC2B) in solution; Nucleic Acids Research; doi:10.1093/nar/gkw617<br>
DOI: 10.6084/m9.figshare.3422716
title: Relationship between <i>Fusarium</i> spp. diversity and mycotoxin contents of mature grains in southern Belgium

description: Over a 4-year period (2010–13), a survey aiming at determining the occurrence of <i>Fusarium</i> spp. and their relations to mycotoxins in mature grains took place in southern Belgium. The most prevalent species were <i>F. graminearum</i>, <i>F. avenaceum, F. poae</i> and <i>F. culmorum</i>, with large variations between years and locations. An even proportion of mating type found for <i>F. avenaceum</i>, <i>F. culmorum</i>, <i>F. cerealis</i> and <i>F. tricinctum</i> is usually a sign of ongoing sexual recombination. In contrast, an unbalanced proportion of mating type was found for <i>F. poae</i> and no <i>MAT1-2</i> allele was present in the <i>F. langsethiae</i> population. Genetic chemotyping indicates a majority of deoxynivalenol (DON)-producing strains in <i>F. culmorum</i> (78%, all 3-ADON producers) and <i>F. graminearum</i> (95%, mostly 15-ADON producers), while all <i>F. cerealis</i> strains belong to the nivalenol (NIV) chemotype. Between 2011 and 2013, DON, NIV, enniatins (ENNs) and moniliformin (MON) were found in each field in various concentrations. By comparison, beauvericin (BEA) was scarcely detected and T-2 toxin, zearalenone and α- and β-zearalenols were never detected. Principal component analysis revealed correlations of DON with <i>F. graminearum</i>, ENNs and MON with <i>F. avenaceum</i> and NIV with <i>F. culmorum</i>, <i>F. cerealis</i> and <i>F. poae</i>. BEA was associated with the presence of <i>F. tricinctum</i> and, to a lesser extent, with the presence of <i>F. poae</i>. The use of genetic chemotype data revealed that DON concentrations were mostly influenced by DON-producing strains of <i>F. graminearum</i> and <i>F. culmorum</i>, whereas the concentrations of NIV were influenced by the number of NIV-producing strains of both species added to the number of <i>F. cerealis</i> and <i>F. poae</i> strains. This study emphasises the need to pay attention to less-studied <i>Fusarium</i> spp. for future <i>Fusarium</i> head blight management strategies, as they commonly co-occur in the field and are associated with a broad spectrum of mycotoxins.
DOI: 10.6084/m9.figshare.3422716.v1
title: Relationship between <i>Fusarium</i> spp. diversity and mycotoxin contents of mature grains in southern Belgium

description: Over a 4-year period (2010–13), a survey aiming at determining the occurrence of <i>Fusarium</i> spp. and their relations to mycotoxins in mature grains took place in southern Belgium. The most prevalent species were <i>F. graminearum</i>, <i>F. avenaceum, F. poae</i> and <i>F. culmorum</i>, with large variations between years and locations. An even proportion of mating type found for <i>F. avenaceum</i>, <i>F. culmorum</i>, <i>F. cerealis</i> and <i>F. tricinctum</i> is usually a sign of ongoing sexual recombination. In contrast, an unbalanced proportion of mating type was found for <i>F. poae</i> and no <i>MAT1-2</i> allele was present in the <i>F. langsethiae</i> population. Genetic chemotyping indicates a majority of deoxynivalenol (DON)-producing strains in <i>F. culmorum</i> (78%, all 3-ADON producers) and <i>F. graminearum</i> (95%, mostly 15-ADON producers), while all <i>F. cerealis</i> strains belong to the nivalenol (NIV) chemotype. Between 2011 and 2013, DON, NIV, enniatins (ENNs) and moniliformin (MON) were found in each field in various concentrations. By comparison, beauvericin (BEA) was scarcely detected and T-2 toxin, zearalenone and α- and β-zearalenols were never detected. Principal component analysis revealed correlations of DON with <i>F. graminearum</i>, ENNs and MON with <i>F. avenaceum</i> and NIV with <i>F. culmorum</i>, <i>F. cerealis</i> and <i>F. poae</i>. BEA was associated with the presence of <i>F. tricinctum</i> and, to a lesser extent, with the presence of <i>F. poae</i>. The use of genetic chemotype data revealed that DON concentrations were mostly influenced by DON-producing strains of <i>F. graminearum</i> and <i>F. culmorum</i>, whereas the concentrations of NIV were influenced by the number of NIV-producing strains of both species added to the number of <i>F. cerealis</i> and <i>F. poae</i> strains. This study emphasises the need to pay attention to less-studied <i>Fusarium</i> spp. for future <i>Fusarium</i> head blight management strategies, as they commonly co-occur in the field and are associated with a broad spectrum of mycotoxins.
DOI: 10.6084/m9.figshare.3422698
title: Involvement of MAK-1 and MAK-2 MAP kinases in cell wall integrity in <i>Neurospora crassa</i>

description: Among three MAPK disruptants of <i>Neurospora crassa</i>, <i>Δmak</i>-<i>1</i> was sensitive and <i>Δmak</i>-<i>2</i> was hypersensitive to micafungin, a beta-1,3-glucan synthase inhibitor, than the wild-type or <i>Δos</i>-<i>2</i> strains. We identified six micafungin-inducible genes that are involved in cell wall integrity (CWI) and found that MAK-1 regulated the transcription of non-anchored cell wall protein gene, <i>ncw</i>-<i>1,</i> and the beta-1,3-endoglucanase gene, <i>bgt</i>-<i>2</i>, whereas MAK-2 controlled the expression of the glycosylhydrolase-like protein gene, <i>gh76</i>-<i>5</i>, and the C4-dicarboxylate transporter gene, <i>tdt</i>-<i>1</i>. Western blotting analysis revealed that, in the wild-type strain, MAK-1 was constitutively phosphorylated from conidial germination to hyphal development. In contrast, the phosphorylation of MAK-2 was growth phase-dependent, and micafungin induced the phosphorylation of unphosphorylated MAK-2. It should be noted that the phosphorylation of MAK-1 was virtually abolished in the <i>Δmak</i>-<i>2</i> strain, but was significantly induced by micafungin, suggesting functional cross talk between MAK-1 and MAK-2 signalling pathway in CWI. Both MAP kinases, MAK-1 and MAK-2, are activated by micafungin, and upregulate the expression of cell wall-related genes.
DOI: 10.6084/m9.figshare.3422698.v1
title: Involvement of MAK-1 and MAK-2 MAP kinases in cell wall integrity in <i>Neurospora crassa</i>

description: Among three MAPK disruptants of <i>Neurospora crassa</i>, <i>Δmak</i>-<i>1</i> was sensitive and <i>Δmak</i>-<i>2</i> was hypersensitive to micafungin, a beta-1,3-glucan synthase inhibitor, than the wild-type or <i>Δos</i>-<i>2</i> strains. We identified six micafungin-inducible genes that are involved in cell wall integrity (CWI) and found that MAK-1 regulated the transcription of non-anchored cell wall protein gene, <i>ncw</i>-<i>1,</i> and the beta-1,3-endoglucanase gene, <i>bgt</i>-<i>2</i>, whereas MAK-2 controlled the expression of the glycosylhydrolase-like protein gene, <i>gh76</i>-<i>5</i>, and the C4-dicarboxylate transporter gene, <i>tdt</i>-<i>1</i>. Western blotting analysis revealed that, in the wild-type strain, MAK-1 was constitutively phosphorylated from conidial germination to hyphal development. In contrast, the phosphorylation of MAK-2 was growth phase-dependent, and micafungin induced the phosphorylation of unphosphorylated MAK-2. It should be noted that the phosphorylation of MAK-1 was virtually abolished in the <i>Δmak</i>-<i>2</i> strain, but was significantly induced by micafungin, suggesting functional cross talk between MAK-1 and MAK-2 signalling pathway in CWI. Both MAP kinases, MAK-1 and MAK-2, are activated by micafungin, and upregulate the expression of cell wall-related genes.
DOI: 10.6084/m9.figshare.3422665
title: Potential involvement of drought-induced Ran GTPase <i>CLRan1</i> in root growth enhancement in a xerophyte wild watermelon

description: Enhanced root growth is known as the survival strategy of plants under drought. Previous proteome analysis in drought-resistant wild watermelon has shown that Ran GTPase, an essential regulator of cell division and proliferation, was induced in the roots under drought. In this study, two cDNAs were isolated from wild watermelon, <i>CLRan1</i> and <i>CLRan2</i>, which showed a high degree of structural similarity with those of other plant Ran GTPases. Quantitative RT-PCR and promoter-GUS assays suggested that <i>CLRan1</i> was expressed mainly in the root apex and lateral root primordia, whereas <i>CLRan2</i> was more broadly expressed in other part of the roots. Immunoblotting analysis confirmed that the abundance of CLRan proteins was elevated in the root apex region under drought stress. Transgenic Arabidopsis overexpressing CLRan1 showed enhanced primary root growth, and the growth was maintained under osmotic stress, indicating that <i>CLRan1</i> functions as a positive factor for maintaining root growth under stress conditions. Ran GTPase (CLRan1), which is expressed in the roots of drought-resistant wild watermelon, functions as a positive factor for maintaining root growth under osmotic stress.