cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.16586015.v1
title: Supplementary Material for: Reference Values for Umbilical Artery Lactate by Mode of Delivery and Gestational Age: A Retrospective Observational Study

description: <b><i>Introduction:</i></b> Umbilical artery cord blood provides information about the intrauterine metabolism during labor. Umbilical artery lactate is a useful parameter in predicting neonatal morbidity, but data on normal values are limited. We aimed to provide reference ranges of umbilical artery lactate values across the combination of gestational age and mode of delivery. <b><i>Methods:</i></b> A single-center retrospective observational study of liveborn infants born between 23 and 42 completed weeks gestation was conducted. Lactate, base deficit (BD), and pH from arterial cord blood were assessed between June 2018 and November 2020 and compared across gestational ages and modes of delivery. <b><i>Results:</i></b> Overall, there were 3,353 infants with evaluable data. Lactate values at the 50th, 90th, and 97th percentile were 3.4, 7.0, and 9.0 mmol/L. Lactate was inversely correlated with pH (<i>r</i> = −0.77, <i>p</i> &lt; 0.001) and positively correlated with BD (<i>r</i> = 0.63, <i>p</i> &lt; 0.001). Lactate values changed significantly across gestational age (Kruskal-Wallis test, <i>p</i> &lt; 0.001) which was attributable to an increase in lactate at 39–41 weeks gestational age. Also, lactate values were different across modes of delivery (Kruskal-Wallis test, <i>p</i> &lt; 0.001) with lowest values in elective CS and highest values in vaginal instrumental deliveries. Comprehensive reference ranges across modes of delivery and gestational ages could be established. <b><i>Discussion:</i></b> Mode of delivery and gestational age contribute to lactate levels with highest values occurring in vaginal instrumental deliveries and between 39 and 41 weeks gestational age. Based on these observations, we provide detailed reference ranges for clinical use.
DOI: 10.6084/m9.figshare.16585997
title: Supplementary Material for: Primary Renal <b><i>BCOR-CCNB3</i></b> Fusion Sarcoma: A Case Report and Review of the Literature

description: <i>BCOR-CCNB3</i> fusion sarcoma is a recently described undifferentiated sarcoma with a novel recurrent inversion of 2 nearby genes <i>BCOR</i> and <i>CCNB3</i>. It typically affects bone and soft tissues of the pelvis, extremity, and paraspinal region and pursues variable clinical course. Primary renal <i>BCOR-CCNB3</i> fusion sarcoma is very rare, and only a small number of cases have been documented. Accurate diagnosis is often challenging, and there is not any agreement for the treatment of this entity due to its rarity. We report findings of primary renal <i>BCOR-CCNB3</i> fusion sarcoma in a 16-year-old boy with a brief review of the literature.
DOI: 10.6084/m9.figshare.16585997.v1
title: Supplementary Material for: Primary Renal <b><i>BCOR-CCNB3</i></b> Fusion Sarcoma: A Case Report and Review of the Literature

description: <i>BCOR-CCNB3</i> fusion sarcoma is a recently described undifferentiated sarcoma with a novel recurrent inversion of 2 nearby genes <i>BCOR</i> and <i>CCNB3</i>. It typically affects bone and soft tissues of the pelvis, extremity, and paraspinal region and pursues variable clinical course. Primary renal <i>BCOR-CCNB3</i> fusion sarcoma is very rare, and only a small number of cases have been documented. Accurate diagnosis is often challenging, and there is not any agreement for the treatment of this entity due to its rarity. We report findings of primary renal <i>BCOR-CCNB3</i> fusion sarcoma in a 16-year-old boy with a brief review of the literature.
DOI: 10.5281/zenodo.5493537
title: Multidimensional Statistical Technique for Interpreting the Spontaneous Breakthrough Cancer Pain Phenomenon. A Secondary Analysis from the IOPS-MS Study

description: Simple Summary: Pain is one of the most common and debilitating symptoms in cancer patients. A clinical peculiarity of cancer pain is the breakthrough cancer pain (BTcP), which is defined as a temporary exacerbation of pain that “breaks through” a phase of adequate pain control by an opioid-based therapy. The NP-BTcP occurs in the absence of any specific activity. In this paper, we addressed the topic through a mathematical approach to provide many indications for identifying the diagnostic and therapeutic gaps in NP-BTcP management. Abstract: Breakthrough cancer pain (BTcP) is a temporary exacerbation of pain that “breaks through” a phase of adequate pain control by an opioid-based therapy. The non-predictable BTcP (NP-BTcP) is a subtype of BTcP that occurs in the absence of any specific activity. Since NP-BTcP has an important clinical impact, this analysis is aimed at characterizing the NP-BTcP phenomenon through a multidimensional statistical technique. This is a secondary analysis based on the Italian Oncologic Pain multiSetting—Multicentric Survey (IOPS-MS). A correlation analysis was performed to characterize the NP-BTcP profile about its intensity, number of episodes per day, and type. The multiple correspondence analysis (MCA) determined the identification of four groups (phenotypes). A univariate analysis was performed to assess differences between the four phenotypes and selected covariates. The four phenotypes represent the hierarchical classification according to the status of NP-BTcP: from the best (phenotype 1) to the worst (phenotype 4). The univariate analysis found a significant association between the onset time &gt;10 min in the phenotype 1 (37.3%)’ vs. the onset &gt; 10 min in phenotype 4 (25.8%) (p &lt; 0.001). Phenotype 1 was characterized by the gastrointestinal type of cancer (26.4%) with respect to phenotype 4, where the most frequent cancer affected the lung (28.8%) (p &lt; 0.001). Phenotype 4 was mainly managed with rapid-onset opioids, while in phenotype 1, many patients were treated with oral, subcutaneous, or intravenous morphine (56.4% and 44.4%, respectively; p = 0.008). The ability to characterize NP-BTcP can offer enormous benefits for the management of this serious aspect of cancer pain. Although requiring validation, this strategy can provide many indications for identifying the diagnostic and therapeutic gaps in NP-BTcP management.
DOI: 10.5281/zenodo.5482508
title: Multidimensional Statistical Technique for Interpreting the Spontaneous Breakthrough Cancer Pain Phenomenon. A Secondary Analysis from the IOPS-MS Study

description: Simple Summary: Pain is one of the most common and debilitating symptoms in cancer patients. A clinical peculiarity of cancer pain is the breakthrough cancer pain (BTcP), which is defined as a temporary exacerbation of pain that “breaks through” a phase of adequate pain control by an opioid-based therapy. The NP-BTcP occurs in the absence of any specific activity. In this paper, we addressed the topic through a mathematical approach to provide many indications for identifying the diagnostic and therapeutic gaps in NP-BTcP management. Abstract: Breakthrough cancer pain (BTcP) is a temporary exacerbation of pain that “breaks through” a phase of adequate pain control by an opioid-based therapy. The non-predictable BTcP (NP-BTcP) is a subtype of BTcP that occurs in the absence of any specific activity. Since NP-BTcP has an important clinical impact, this analysis is aimed at characterizing the NP-BTcP phenomenon through a multidimensional statistical technique. This is a secondary analysis based on the Italian Oncologic Pain multiSetting—Multicentric Survey (IOPS-MS). A correlation analysis was performed to characterize the NP-BTcP profile about its intensity, number of episodes per day, and type. The multiple correspondence analysis (MCA) determined the identification of four groups (phenotypes). A univariate analysis was performed to assess differences between the four phenotypes and selected covariates. The four phenotypes represent the hierarchical classification according to the status of NP-BTcP: from the best (phenotype 1) to the worst (phenotype 4). The univariate analysis found a significant association between the onset time &gt;10 min in the phenotype 1 (37.3%)’ vs. the onset &gt; 10 min in phenotype 4 (25.8%) (p &lt; 0.001). Phenotype 1 was characterized by the gastrointestinal type of cancer (26.4%) with respect to phenotype 4, where the most frequent cancer affected the lung (28.8%) (p &lt; 0.001). Phenotype 4 was mainly managed with rapid-onset opioids, while in phenotype 1, many patients were treated with oral, subcutaneous, or intravenous morphine (56.4% and 44.4%, respectively; p = 0.008). The ability to characterize NP-BTcP can offer enormous benefits for the management of this serious aspect of cancer pain. Although requiring validation, this strategy can provide many indications for identifying the diagnostic and therapeutic gaps in NP-BTcP management.
DOI: 10.5281/zenodo.5493484
title: GeoMx DSP dataset of "Integrated multi-omics reveals cellular and molecular interactions governing the invasive niche of skin cancer"

description: This data set is linked to the paper "Integrated multi-omics reveals cellular and molecular interactions governing the invasive niche of skin cancer". It contains datasets from GeoMx DSP analysis.
DOI: 10.6084/m9.figshare.16586027
title: Untitled Item

description: This data is used in the Examining priors and outcoms of decent work among Korean workers paper. It is saved in sav format.
DOI: 10.6084/m9.figshare.16586027.v2
title: Untitled Item

description: This data is used in the Examining priors and outcoms of decent work among Korean workers paper. It is saved in sav format.
DOI: 10.6084/m9.figshare.16586027.v1
title: Untitled Item

description: This data is used in the Examining priors and outcoms of decent work among Korean workers paper. It is saved in sav format.
DOI: 10.5281/zenodo.5482187
title: CFD dataset for AMR-Net

description: This dataset contains the two dimensional fluid simulation data for AMR-Net. The inputs of simulations are signed distance functions (SDFs) and the outputs are 2D flow fields u and v. In each simulation, 1-5 objects are placed randomly at the center of the computational domain. The objects are randomly chosen from circles, ellipses, rectangles and rounded rectangles. Each hdf5 file includes the pair of input and output data. The details of the dataset is described in the Github page.
DOI: 10.5281/zenodo.5482186
title: CFD dataset for AMR-Net

description: This dataset contains the two dimensional fluid simulation data for AMR-Net. The inputs of simulations are signed distance functions (SDFs) and the outputs are 2D flow fields u and v. In each simulation, 1-5 objects are placed randomly at the center of the computational domain. The objects are randomly chosen from circles, ellipses, rectangles and rounded rectangles. Each hdf5 file includes the pair of input and output data. The details of the dataset is described in the Github page.
DOI: 10.5281/zenodo.5493548
title: Opinion of ethics committee representatives on the use of social networks and new technologies in clinical trials. Nominal group

description: Nominal group database to find out the opinion of ethics committee representatives on the use of social networks and new technologies in clinical trials.
DOI: 10.7910/dvn/zo6erx
title: DATW

description: Dataset used for the paper intitled "Leveraging User Data to Investigate the Effectiveness of Interstitial Ads in Mobile Game Applications: Evidence from a Field Experiment"
DOI: 10.5281/zenodo.5493556
title: Opinion of ethics committee representatives on the use of social networks and new technologies in clinical trials. Nominal group

description: Nominal group database to find out the opinion of ethics committee representatives on the use of social networks and new technologies in clinical trials.
DOI: 10.5281/zenodo.5482382
title: Lithuanian Household Energy Expenditure and Energy Poverty Data, 2019

description: This dataset provides data about household energy expenditure and energy poverty in Lithuania. The dataset contains detailed data about 5031 households and is based on the Lithuanian Survey on Income and Living Conditions (2019) micro dataset provided by Statistics Lithuania. It includes additional data derived from original survey data and energy poverty calculation results at household level. Duomenų rinkinyje pateikiami duomenys apie namų ūkių energijos išlaidas ir energijos nepriteklių Lietuvoje 2019 metais. Duomenų rinkinys apima 5131 namų ūkį. Rinkinio pagrindas - Pajamų ir gyvenimo sąlygų statistinio tyrimo duomenys, skelbiami Lietuvos Statistikos departamento. Duomenų rinkinys apima ir papildomus duomenis gautus remiantis originalios apklausos duomenimis bei energijos nepritekliaus skaičiavimų rezultatus namų ūkio lygmenyje.
description: This project has received funding from the Research Council of Lithuania (LMTLT), agreement No S-REP-20-3.
DOI: 10.5281/zenodo.5482381
title: Lithuanian Household Energy Expenditure and Energy Poverty Data, 2019

description: This dataset provides data about household energy expenditure and energy poverty in Lithuania. The dataset contains detailed data about 5031 households and is based on the Lithuanian Survey on Income and Living Conditions (2019) micro dataset provided by Statistics Lithuania. It includes additional data derived from original survey data and energy poverty calculation results at household level. Duomenų rinkinyje pateikiami duomenys apie namų ūkių energijos išlaidas ir energijos nepriteklių Lietuvoje 2019 metais. Duomenų rinkinys apima 5131 namų ūkį. Rinkinio pagrindas - Pajamų ir gyvenimo sąlygų statistinio tyrimo duomenys, skelbiami Lietuvos Statistikos departamento. Duomenų rinkinys apima ir papildomus duomenis gautus remiantis originalios apklausos duomenimis bei energijos nepritekliaus skaičiavimų rezultatus namų ūkio lygmenyje.
description: This project has received funding from the Research Council of Lithuania (LMTLT), agreement No S-REP-20-3.
DOI: 10.5281/zenodo.5493561
title: Opinion of ethics committee representatives on the use of social networks and new technologies in clinical trials. Nominal group

description: Nominal group database to find out the opinion of ethics committee representatives on the use of social networks and new technologies in clinical trials.
DOI: 10.5281/zenodo.5416263
title: Dataset related to article "C3a receptor blockade protects podocytes from injury in diabetic nephropathy"

description: <em>The file contains raw data related to the article "C3a receptor blockade protects podocytes from injury in diabetic nephropathy", available from https://insight.jci.org/articles/view/131849.</em> <strong>Raw data vivo 1</strong>: evaluations of complement protein renal expression in vivo <strong>Raw data vivo 2</strong>: evaluations of systemic and laboratory parameters in vivo <strong>Raw data vivo 3</strong>: histological evaluation of glomerular damage in vivo <strong>Raw data vivo 4</strong>: histological evaluation of podocyte and mitochondrial dysfunction in vivo <strong>Raw data vitro 1</strong>: evaluations of mitochondrial functional integrity in cultured podocytes <strong>Raw data vitro 2</strong>: western blot analyses of mitochondrial proteins in cultured podocytes <strong>Raw data vitro 3</strong>: evaluations of mitochondrial bioenergetic changes in cultured podocytes <strong>Raw data vitro 4</strong>: evaluations of the effect of SS-31 in cultured podocytes <strong>Abstract of the manuscript</strong>: Renal activation of the complement system has been described in patients with diabetic nephropathy (DN), although its pathological relevance is still ill-defined. Here, we studied whether glomerular C3a, generated by uncontrolled complement activation, promotes podocyte damage, leading to proteinuria and renal injury in mice with type 2 diabetes. BTBR ob/ob mice exhibited podocyte loss, albuminuria, and glomerular injury accompanied by C3 deposits and increased C3a and C3a receptor (C3aR) levels. Decreased glomerular nephrin and α-actinin4 expression, coupled with integrin-linked kinase induction, were also observed. Treatment of DN mice with a C3aR antagonist enhanced podocyte density and preserved their phenotype, limiting proteinuria and glomerular injury. Mechanistically, ultrastructural and functional mitochondrial alterations, accompanied by downregulation of antioxidant superoxide dismutase 2 (SOD2) and increased protein oxidation, occurred in podocytes and were normalized by C3aR blockade. In cultured podocytes, C3a induced cAMP-dependent mitochondrial fragmentation. Alterations of mitochondrial membrane potential, SOD2 expression, and energetic metabolism were also found in response to C3a. Notably, C3a-induced podocyte motility was inhibited by SS-31, a peptide with mitochondrial protective effects. These data indicate that C3a blockade represents a potentially novel therapeutic strategy in DN for preserving podocyte integrity through the maintenance of mitochondrial functions.
description: {"references": ["Morigi M, Perico L, Corna D, Locatelli M, Cassis P, Carminati CE, Bolognini S, Zoja C, Remuzzi G, Benigni A, Buelli S. C3a receptor blockade protects podocytes from injury in diabetic nephropathy. JCI Insight. 2020 Mar 12;5(5):e131849. doi: 10.1172/jci.insight.131849. PMID: 32161193; PMCID: PMC7141402."]}
DOI: 10.5281/zenodo.5416262
title: Dataset related to article "C3a receptor blockade protects podocytes from injury in diabetic nephropathy"

description: <em>The file contains raw data related to the article "C3a receptor blockade protects podocytes from injury in diabetic nephropathy", available from https://insight.jci.org/articles/view/131849.</em> <strong>Raw data vivo 1</strong>: evaluations of complement protein renal expression in vivo <strong>Raw data vivo 2</strong>: evaluations of systemic and laboratory parameters in vivo <strong>Raw data vivo 3</strong>: histological evaluation of glomerular damage in vivo <strong>Raw data vivo 4</strong>: histological evaluation of podocyte and mitochondrial dysfunction in vivo <strong>Raw data vitro 1</strong>: evaluations of mitochondrial functional integrity in cultured podocytes <strong>Raw data vitro 2</strong>: western blot analyses of mitochondrial proteins in cultured podocytes <strong>Raw data vitro 3</strong>: evaluations of mitochondrial bioenergetic changes in cultured podocytes <strong>Raw data vitro 4</strong>: evaluations of the effect of SS-31 in cultured podocytes <strong>Abstract of the manuscript</strong>: Renal activation of the complement system has been described in patients with diabetic nephropathy (DN), although its pathological relevance is still ill-defined. Here, we studied whether glomerular C3a, generated by uncontrolled complement activation, promotes podocyte damage, leading to proteinuria and renal injury in mice with type 2 diabetes. BTBR ob/ob mice exhibited podocyte loss, albuminuria, and glomerular injury accompanied by C3 deposits and increased C3a and C3a receptor (C3aR) levels. Decreased glomerular nephrin and α-actinin4 expression, coupled with integrin-linked kinase induction, were also observed. Treatment of DN mice with a C3aR antagonist enhanced podocyte density and preserved their phenotype, limiting proteinuria and glomerular injury. Mechanistically, ultrastructural and functional mitochondrial alterations, accompanied by downregulation of antioxidant superoxide dismutase 2 (SOD2) and increased protein oxidation, occurred in podocytes and were normalized by C3aR blockade. In cultured podocytes, C3a induced cAMP-dependent mitochondrial fragmentation. Alterations of mitochondrial membrane potential, SOD2 expression, and energetic metabolism were also found in response to C3a. Notably, C3a-induced podocyte motility was inhibited by SS-31, a peptide with mitochondrial protective effects. These data indicate that C3a blockade represents a potentially novel therapeutic strategy in DN for preserving podocyte integrity through the maintenance of mitochondrial functions.
description: {"references": ["Morigi M, Perico L, Corna D, Locatelli M, Cassis P, Carminati CE, Bolognini S, Zoja C, Remuzzi G, Benigni A, Buelli S. C3a receptor blockade protects podocytes from injury in diabetic nephropathy. JCI Insight. 2020 Mar 12;5(5):e131849. doi: 10.1172/jci.insight.131849. PMID: 32161193; PMCID: PMC7141402."]}
DOI: 10.5281/zenodo.5493571
title: Opinion of ethics committee representatives on the use of social networks and new technologies in clinical trials. Nominal group

description: Nominal group database to find out the opinion of ethics committee representatives on the use of social networks and new technologies in clinical trials.
DOI: 10.5281/zenodo.5234075
title: Data for Pelgrim et al. (2021) Scientific Reports

description: Dataset for Pelgrim et al. (2021). Functional connectivity (FC) matrices were created by computing Pearson correlation coefficients between the mean time course of 105 regions of interest (ROIs) of the functional MRI images, then converted to normally distributed <em>Z</em>-scores using Fisher's r-to-<em>Z</em>-transformation. - 40 connectivity matrices of 22q11 deletion syndrome patients<br> - 76 connectivity matrices of healthy controls <br> - subject data<br> - names of 105 ROIs 22q11 deletion syndrome, psychosis, functional MRI, network analysis, graph theory, functional connectivity
description: This work was funded by the Agencia Nacional de Investigación y Desarrollo from Chile (ANID), through its grants ANILLO PIA ACT192064, FONDECYT regular 1200601, and Millenium Nucleus for Cardiovascular Disease NCN17_129.
DOI: 10.5281/zenodo.5234074
title: Data for Pelgrim et al. (2021) Scientific Reports

description: Dataset for Pelgrim et al. (2021). Functional connectivity (FC) matrices were created by computing Pearson correlation coefficients between the mean time course of 105 regions of interest (ROIs) of the functional MRI images, then converted to normally distributed <em>Z</em>-scores using Fisher's r-to-<em>Z</em>-transformation. - 40 connectivity matrices of 22q11 deletion syndrome patients<br> - 76 connectivity matrices of healthy controls <br> - subject data<br> - names of 105 ROIs 22q11 deletion syndrome, psychosis, functional MRI, network analysis, graph theory, functional connectivity
description: This work was funded by the Agencia Nacional de Investigación y Desarrollo from Chile (ANID), through its grants ANILLO PIA ACT192064, FONDECYT regular 1200601, and Millenium Nucleus for Cardiovascular Disease NCN17_129.
DOI: 10.5281/zenodo.5464959
title: Evaluation of the loss of cut by photodiode intensity with modulated power

description: Laser cutting is widely used in the industry as a manufacturing method for metallic sheet processing. On it a laser source melts the material, which is evacuated with the use of an assisted gas. However, system or material irregularities can move the process out of the stable condition and lead to a loss of cut, producing material and economic losses. Several monitoring methods are being investigated in the industry in order to detect the loss of cut and anticipate it. Our work focusses on the detection of the loss of cut by analysing the radiation emitted during the process by means of a photodiode.
DOI: 10.5281/zenodo.5464958
title: Evaluation of the loss of cut by photodiode intensity with modulated power

description: Laser cutting is widely used in the industry as a manufacturing method for metallic sheet processing. On it a laser source melts the material, which is evacuated with the use of an assisted gas. However, system or material irregularities can move the process out of the stable condition and lead to a loss of cut, producing material and economic losses. Several monitoring methods are being investigated in the industry in order to detect the loss of cut and anticipate it. Our work focusses on the detection of the loss of cut by analysing the radiation emitted during the process by means of a photodiode.