cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.14290869.v1
title: Effect of drying methods on the powder and compaction properties of microcrystalline cellulose derived from Gossypium herbaceum

description: The effect of drying method, a process variable, on the powder and compaction properties of microcrystalline cellulose (MCC) obtained from the partial acid hydrolysis of bleached alpha (α) cellulose content of matured linters of Gossypium herbaceum (GH) was investigated. A portion of the wet MCC obtained was fluid bed dried at 60 ± 1 ºC, inlet air of 30 m3 min-1 for 3 h (coded MCC-GossF). The second portion was lyophilized at - 45 ± 2 ºC for 6 h (coded MCC-GossL). The physicochemical, scanning electron micrographs, X ray diffraction patterns and micromeritic properties of the derived MCCs were determined using standard methods. The cohesiveness and compactibility of the powders were investigated using Kawakita model while the deformation and compressibility pattern were determined using Heckel model. Avicel® PH 102 (AV-102) was used as comparing standard. Ash values of &lt; 2%, pH (6.54 ± 0.23 to 6.58 ± 0.08), degree of polymerization, DP (231.50) was obtained. MCC-GossF had higher moisture content, swellability, better flow indices, and lesser porosity than MCC-GossL. Kawakita model demonstrated good consolidation and compactibility for both powders. Compacts of MCC-GossL were significantly (p &lt; 0.05) harder than those of MCC-GossF. Heckel analysis demonstrated good compressibility and deformation pattern that was comparable with AV-102. Compacts of MCC-GossL had better mechanical and tablet compression properties than MCC-GossF. Method of drying significantly (p &lt; 0.05) affected the powder and compaction properties of GH MCC.
DOI: 10.6084/m9.figshare.14290865.v1
title: Polymeric micelles containing resveratrol: development, characterization, cytotoxicity on tumor cells and antimicrobial activity

description: Antimicrobial and antitumor activities of resveratrol, a compound found mainly in grapes, have already been demonstrated. However, its low bioavailability is a limiting factor for therapeutic application. Polymeric micelles can be an approach to solve this problem since they can encapsulate hydrophobic substances. We developed and characterized micellar formulations containing resveratrol and evaluated their cytotoxic and antimicrobial effects. The formulations were prepared by the cold dispersion method with different concentrations of F127 (5 or 10% w/w) and resveratrol (500 or 5000 µM). The formulations were characterized according to size, polydispersity index, pH, encapsulation rate and in vitro release. Cytotoxic effect was evaluated on a bladder cancer cell line and antimicrobial effect was evaluated on E. coli, S. aureus and C. albicans. One of the formulations (10% w/w of F127 and 5000 µM of resveratrol) was a monodispersed solution with high encapsulation rate, thus it was chosen for the cytotoxicity and antimicrobial assays. MS- 10+RES-3 was able to preserve the antimicrobial and cytotoxic activity of resveratrol. This is the first study that evaluated antimicrobial potential and cytotoxicity of micelles containing resveratrol on bladder cancer cells and the results showed that micellar nanostructures could ensure the maintenance of the biological activity of resveratrol.
DOI: 10.6084/m9.figshare.14290864.v1
title: Nonadherence to treatment recommendations is a factor contributing to the clinical failure of daptomycin: Cohort study in Brazil

description: To evaluate the clinical outcomes of daptomycin therapy and adherence to treatment recommendations, a retrospective cohort study was conducted with patients that received daptomycin during the period of the study. The adherence and nonadherence to clinical guidelines were assessed through organism identification, dose and time of treatment, management of bacteremia, and vancomycin treatment failure. A multiple logistic regression model analyzed the association between independent variables and clinical success (dependent variable), considering 5% of statistical significance. The study presented 52 patients who received daptomycin for the treatment of bacteremia (21.1%) or infections (osteomyelitis [63.5%], synovial fluid [15.4%]). Most patients (86.5%) received daptomycin as the second line of treatment, and 51.9% achieved clinical success. The patients had a better chance of clinical success when they followed the guideline indications (OR = 16.86; 95% CI = 1.45-195.88) and the medication was prescribed by a specialist in infectious diseases (OR = 4.84; 95% CI = 1.11-21.09). The study demonstrated lower clinical success than that described in the literature because of patients who were not eligible according to the clinical guidelines. Adherence to recommendations and appropriate prescription of reserve antibiotics is important in limiting early resistance, and avoiding clinical failure and unnecessary expenditure.
DOI: 10.6084/m9.figshare.14290861.v1
title: Enzyme inhibition and antibacterial potential of 4-Hydroxycoumarin derivatives

description: The 4-Hydroxycoumarin derivatives are known to show a broad spectrum of pharmacological applications. In this paper we are reporting the synthesis of a new series of 4-Hydroxycoumarin derivatives synthesized through Knovenegal condensation; they were characterized by using UV-Vis, FT-IR, NMR spectroscopies. The synthesized compounds were evaluated for antibacterial activity against Staphylococcus aureus and Salmonella typhimurium strains. The compounds (2), (3) and (8) showed favorable antibacterial activity with zone of inhibitions 26.5± 0.84, 26.0 ± 0.56 and 26.0 ± 0.26 against Staphylococcus aureus (Gram-positive) respectively. However, the compounds (5) and (9) were found more active with 19.5 ± 0.59 and 19.5 ± 0.32 zone of inhibitions against Salmonella typhimurium (Gram-negative). Whereas, in urease inhibition assay, none of the synthesized derivatives showed significant anti-urease activity; although, in carbonic anhydrase-II inhibition assay, the compound (2) and (6) showed enzyme inhibition activity with IC50 values 263±0.3 and 456±0.1, respectively.
DOI: 10.6084/m9.figshare.14290857.v1
title: Antitumor efficacy of EDTA co-treatment with cisplatin in tumor-bearing mice

description: Ethylenediamine tetraacetic acid (EDTA) is used in various medical applications. The aim of this study is to investigate the antitumor efficacy of EDTA alone or with cisplatin (Cis). Fifty male albino mice were used to assess the median lethal dose (LD50) of EDTA via intraperitoneal (i.p) injection. To determine the antitumor activity, fifty female albino mice were divided into five groups as the following; Group 1 (Gp1) was negative control; (Gp2-5) inoculated i.p with 2×106 Ehrlich Ascites Carcinoma (EAC) cells/mouse. After one day, Gp3, Gp4 and Gp5 injected with Cis (2 mg/kg), EDTA (25 mg/kg) and Cis (2 mg/kg)/EDTA (25 mg/kg) for six days, respectively. At day 14, all groups were sacrificed to assess the tumor profile, liver enzymes (alanine transaminases and aspartate transaminases), kidney function (urea and creatinine) and electrolytes (Na+, K+ and Ca2+). The results showed that the i.p LD50 of EDTA was 250 mg/kg. Treatment with EDTA alone did not show any antitumor activity and did not interfere with the antitumor efficacy of Cis. Biochemical findings revealed that EDTA had mild toxicity on liver and kidneys functions. In summary, EDTA had no antitumor effect and did not alter the Cis efficacy.
DOI: 10.6084/m9.figshare.14290855.v1
title: Evaluating the effects of vanadyl sulfate on biomarkers of oxidative stress and inflammation in renal tissue of rats with diabetes type 2

description: Vanadyl sulfate (VS) is an ingredient in some food supplements and experimental drugs. This study was designed to assay the effects of VS on biomarkers of oxidative stress and inflammation in renal tissue of rats with diabetes type 2. 30 male Wistar rats were divided into three equal groups as follow: non-diabetics, non-treated diabetics and VS-treated diabetics. Diabetes type 2 has been induced through high fat diet and fructose in the animals. Diabetic rats were treated with 25 mg/kgBW of VS in water for 12 weeks. At the end of study, glucose and insulin were measured using commercially available kits in serum and biomarkers of oxidative stress and inflammation in renal homogenates of animals were measured by related methods. Compared to controls, glucose and insulin were increased significantly in non-treated diabetic rats (p-value &lt;0.05) that showed the induction of diabetes type 2 in rats. The results showed that in VS-treated diabetic rats compared to the non-treated diabetic group, vanadyl sulfate significantly reduced the glucose and insulin secretion and changed renal inflammatory and oxidative markers, except protein carbonyl so that we couldn’t find any significant changes. Our study showed that vanadyl supplementation had positive effects on oxidative stress and inflammation biomarkers in kidney of diabetic rats.
DOI: 10.6084/m9.figshare.14290854.v1
title: Development of amphotericin b Based organogels against mucocutaneous fungal infections

description: Amphotericin B is a broad spectrum antifungal agent used to treat fungal infections. Organogel is a semisolid preparation in which the apolar phase gets immobilized within spaces of the three-dimensional structure. The current study aimed at the formulation and comparative evaluation of sorbitan monostearate organogels and pluronic lecithin organogels (PLO). Different compositions of span 60 based organogels were prepared by varying the concentrations of the span 60 and PLO gels were prepared by varying the concentration of Pluronic F 127. The developed organogels were subjected to various characteristics such as pH, viscosity, spreadability, extrudability, and drug release studies. The optimized formulations were evaluated against Candida albicans and carried out ex vivo release study. The optimized formulation was selected from span 60 based organogels, and pluronic lecithin organogels were S1 and P1, respectively. The optimized formulation (S1) showed effective inhibition against Candida albicans. The skin irritation test was carried out on albino mice for optimized formulations and results showed that no irritation to the skin. Based on the results, organogels prepared by sorbitan monostearate showed better antifungal activity, and also all the formulations were found to be stable and safe throughout the study period.
DOI: 10.6084/m9.figshare.14290852.v1
title: Nesiritide protects endothelial function after balloon-induced trauma in the iliac artery in rabbits

description: To assess the effect of nesiritide on the endothelial function of iliac arteries following endothelia trauma. Right iliac artery trauma was created with a balloon catheter. Ten rabbits were treated with a 4-week subcutaneous injection of nesiritide at a fixed daily dose of 0.1mg/kg. Ten rabbits received daily normal saline injection. Plasma endothelin 1 (ET-1), nitric oxide (NO), and Von Willebrand Factor (vWF) were measured before and after the therapies. Tissue proliferating cell nuclear antigen (PCNA) was measured after the treatment. After the treatment, in the therapeutic group, the area under internal elastic membrane and the residual lumen area were higher than in the normal saline group (P &lt;0.05). The plasma levels of ET-1 (91.6±6.8 vs 114.9±6.3 ng/L, P =0.001), vWF (134.6±10.8% vs 188.8±10.4%, P =0.001) and the ratio of PCNA positive expression (11.7±4.2% vs 36.2±11.4%, P =0.005) in the therapeutic group was lower than in the normal saline group, while the plasma levels of NO was higher (89.7±9.3 vs 43.5±5.3 µmol/L, P =0.001). Nesiritide inhibited remodeling of rabbit iliac artery following endothelial trauma. The inhibition of vascular remodeling may be related to the alleviated endothelial dysfunction and reduced expression of tissue proliferating cell nuclear antigen.
DOI: 10.6084/m9.figshare.14290851.v1
title: Evaluation of the bioequivalence of two formulations containing the combination of 400 mg of acetaminophen (paracetamol), 4 mg of phenylephrine and 4 mg of chlorpheniramine in capsules: open-label, three-way crossover study, partially replicated in healthy volunteers of both sexes

description: This study was carried out in order to compare the relative bioavailability of two different formulations containing 400 mg of acetaminophen + 4 mg of phenylephrine hydrochloride + 4 mg of chlorpheniramine maleate, Test formulation (Cimegripe®) and Reference formulation (Resfenol®) in 84 healthy volunteers of both sexes under fasting conditions. The study was conducted in a single dose, randomized, open-label, crossover 3-way and partially replicated. The tolerability was evaluated by the monitoring of adverse events and vital signs, results of clinical and laboratory tests. Plasma concentrations were quantified by validated bioanalytical methods using the ultra-performance liquid chromatography coupled to tandem mass spectrometry. The Cmax, Tmax, AUC0-t, AUC0-inf, T1/2 and Kel pharmacokinetic parameters were calculated from these obtained concentrations. The 90% confidence intervals were constructed for the ratio reference/test from the geometric average of the Cmax and AUC parameters which were comprised between 80% and 125%. Only the Cmax parameter of the phenylephrine was applied the scaled average bioequivalence due to the intraindividual coefficient of variation &gt; 30% obtained, thus extending the acceptance limits of the interval. It can be concluded that the two formulations were bioequivalent in terms of rate and absorption extent and thus interchangeable.
DOI: 10.6084/m9.figshare.14290849.v1
title: Lupine as a potential agent against diet-induced obesity through adenosine monophosphate-activated protein kinase pathway: crude oil versus nanoemulsion formulations

description: Obesity represents a major challenge to the pharmaceutical community due to the minimal availability of anti-obesity drugs and the drawbacks of current weight-loss agents. The study described herein presents lupine oil, in two pharmaceutical formulations, as a potential anti-obesity agent via its effect on different physiological, biochemical, and hormonal parameters. Rats were divided into two groups; one group was continued on a standard commercial rodent diet and served as the non-obese control. The other group was fed a high-fat diet for 7 weeks to prepare an obese rat model. Then, the obese rats were divided into groups to receive 100 mg/kg of the crude lupine oil or nanoemulsion for 10 or 20 days. Lupine oil showed a potent body weight-reducing effect and improved insulin resistance. The oil altered obesity-induced hyperlipidemia and it enhanced the leptin/adiponectin/AMPK hormonal system in epididymal fat, serum, and liver, to which all the above physiological activities could be attributed. The nanoemulsion formulation of lupine oil significantly amplified the activity for all the above physiological and hormonal parameters when compared to the crude oil formulation. Lupine oil nanoemulsion could be used as a potential drug against diet-induced obesity.
DOI: 10.6084/m9.figshare.14290847.v1
title: Passion fruit (Passiflora edulis) leaf extract modulates the oxidative metabolism of rat peritoneal neutrophils in a model of inflammation

description: This study was conducted to evaluate the effect of extracts of Passiflora edulis Sims leaves on the oxidative metabolism of rat peritoneal neutrophils using a model of acute inflammation. The extract was obtained by maceration in 70% ethanol, evaporation under reduced pressure and lyophilisation. Total phenolic content (TP) was determined by the Folin-Ciocalteu assay. The P. edulis extract, in different doses, was administered by gavage 1 h prior to inflammation induction by carrageenan (8 mg/kg, i.p.); five hours later, the neutrophils were obtained by intraperitoneal lavage. The tests performed in neutrophils were cytochrome C and chemiluminescence assay as well as myeloperoxidase (MPO), superoxide dismutase (SOD), glutathione peroxidase (GPx) and catalase (CAT) activities. The administration of the extract reduced the number of neutrophils recruited to the site of inflammation; however, the extract did not alter the activity of NADPH oxidase as well as SOD activity in these cells. The MPO and CAT activities in peritoneal neutrophils of rat treated with extract was lower than in the control group, and the GPx activity was increased. Based on the experimental model utilised, the anti-inflammatory potential of P. edulis leaf extract could be related to the presence of phenolic compounds in the extract.
DOI: 10.6084/m9.figshare.14290662.v1
title: MORPHOSYNTACTIC ALIGNMENT OF HÑÄHÑU (MEZQUITAL VALLEY OTOMI)

description: ABSTRACT: This paper describes the subject and object alignments in Hñähñu (Mezquital Valley Otomi), and compares some of their grammatical, lexical, and semantic features to those in the corresponding descriptions of Querétaro Otomi and Acazulco Otomi. The analysis presented is based on the characterization of semantic alignment by Mithun (1991) and Donohue (2008), and that of object alignment by Dryer (1986) and Haspelmath (2005); thematic roles are defined by following Bickel's (2012) grammatical relation typology. With respect to subject alignment, the split-S systems in the three languages being compared has two classes of intransitive verbs: verbs with a non-agentive S (O-verbs), and the rest (A-verbs). The three languages differ in the number of lexemes within the O-verb class, and in the number of fluid-S verbs; the morphology of O-verbs presents minor contrasts among the three. As for object alignment, the mixed characterization (i.e., indirective, as well as secundative, features) of the Hñähñu system derived from four morphosyntactic criteria suggests that the marking of object in Otomi languages obeys mechanisms that go beyond thematic roles.
DOI: 10.6084/m9.figshare.14290657.v1
title: CRITICAL PERIOD AND PHONOLOGICAL ACQUISITION OF ENGLISH BY BRAZILIAN SPEAKERS

description: ABSTRACT: This article discusses the influence of age of acquisition on the process of learning a foreign language. We analyzed the acquisition of three phonological processes in English by speakers of Brazilian Portuguese and applied experiments on fricative voicing, stress shift and stress assignment to participants at three levels of proficiency: basic, intermediate and advanced. The results demonstrated that the age factor was relevant in two processes (stress shift and stress assignment) – at least at certain levels of proficiency. On the other hand, fricative voicing was not acquired by Brazilian speakers in any level of proficiency, regardless of age of acquisition.
DOI: 10.6084/m9.figshare.14290636.v1
title: “SÓ”, “EXCLUSIVAMENTE” AND THEIR POSITIONS IN THE SENTENCE

description: In this paper, I examine some properties of higher and lower adverbs to suggest that the focusing só ‘only’ belongs to the first group. I argue that the behavior of exclusive só in Brazilian Portuguese is better explained on syntactic grounds, i.e. in terms of its position in the universal hierarchy. The key to arrive at this conclusion comes from the distribution of the focusing exclusivamente ‘exclusively’ which is also an exclusive adverb but behaves differently from só with respect to some syntactic properties which discriminate between lower and higher adverbs. I will show that Bever and Clark’s (2008) predictions that Semantics would be responsible for the asymmetries between quantificational adverbs and the exclusive só is not accurate inasmuch as exclusive exclusivamente ‘exclusively’, in Brazilian Portuguese, goes together with quantificational adverbs as far as some syntactic properties are examined.
DOI: 10.6084/m9.figshare.14290444.v1
title: Effects of rainwater intrusion on an activated sludge sewer treatment system

description: Abstract Effluent collection and stormwater management make use of different drainage systems, which should remain unconnected with one another. If stormwater drains into sewage collection systems, it often causes changes in effluent quality indicators at sewage treatment plants. This study sought to quantify the changes caused by rain in a Wastewater Treatment Plant (WWTP) located in Paulista, PE, which uses the activated sludge system. Accordingly, changes in pH, temperature, BOD, and treatment efficiency at the inlet and outlet, as well as inlet flow were analyzed on dry and rainy days at the plant, which has a sewage capacity of 400 L s-1. The input volume was found to be greater than the design flow of the station, about 25%. With this, some relevant operational controls were identified, such as temporarily shutting down sewage pumping stations in order to maintain full operation of the system and avoid overload. The pH increases slightly in alkalinity, about 0.3, but this does not interfere with the treatment process. The temperature of the influent on rainy days is about 3 to 5 degrees cooler, depending on the intensity of the event. Using the T and Z tests, it was possible to identify that BOD concentrations in the influent and the effluent were not significantly different (uneq. var. t: 1.18 &gt; 0.26 and uneq var. z: 0.71 &gt; 0.48, respectively), and the organic load removal efficiency was maintained, contrary to what is expected with other, more simple types of treatment.
DOI: 10.13139/ornlnccs/1772222
title: Las Vegags Block Group Buildings Data

description: These data include a comprehensive summary of all residential and commercial buildings in the Las Vegas Assessors office dataset as it was on Feb 28th 2021. Building level data has been summarized to the US Census 2020 Block Group geographies.
DOI: 10.6084/m9.figshare.14289850.v1
title: Quality of life and informal labor among elderly persons in an intermediate Colombian city, 2012-2013

description: Abstract Objective: Describe the quality of life of elderly informal workers in an intermediate Colombian city. Method: A descriptive study of 320 randomly selected informal workers aged older than 18 from Manizales was performed. A sub-sample of 153 people aged older than 50, representing 47.8 percent of the study population, was performed. Two instruments were applied: one testing demographic variables and the WHOQOL-BREF quality of life questionnaire. Univariate and bivariate analyzes were performed using frequency distributions and the chi-squared test was used to identify association between variables. Results: 69.9% of the participants were men, the average age was 59.4 (+7.2) years, 62.0% had no or basic education, 52.0% belonged to social class 1 and 2; 6.5% had no affiliation with the health and social security system. The different dimensions of quality of life were perceived favorably, as was health. More than 50.0% were autonomous, had strong social and family networks, had not experienced negative feelings and found meaning to life. Statistical differences (p&lt;0.05) by gender and age were found for environment, sex life, daily living skills, and satisfaction with work capacity. Conclusion: The quality of life of older informal workers is well perceived and is related to a positive assessment of health. From the perspective of human development, work gives meaning to the lives of older people and encourages active, healthy and productive aging.