cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.21936699.v1
title: The influence of fluoxetine on orthodontic tooth movement in rats

description: Abstract This study aimed to evaluate the effects of chronic use of fluoxetine on the amount of orthodontic tooth movement and tissue changes in rats. A total of 192 Wistar rats were divided into 4 groups: S, 0.9% saline solution; F, 20 mg/kg of fluoxetine; SM, 0.9% saline solution with orthodontic movement; and FM, 20 mg/kg of fluoxetine with orthodontic movement. After 30 days of daily saline or fluoxetine administration, an orthodontic device (25cN) was used to mesially displace the first molar in animals of the groups SM and FM. The animals were euthanized 2, 7, 14, and 28 days after placement of the orthodontic appliances and animals of groups S and F were euthanized at the same time. The assessment of tooth movement was made in gypsum castings, the collagen neoformation was assessed by polarization microscopy, the number of osteoclasts and root resorption were evaluated using tartrate-resistant acid phosphatase, and presence of hyalinized areas was assessed by hematoxylin-eosin staining. Fluoxetine did not affect the amount of tooth displacement, percentage of collagen, number of osteoclasts, and presence of hyalinized areas (P&gt;0.05). There was a higher frequency of root resorption areas in the FM group than in the SM group only on the second day (P&lt;0.05). The findings of this study show that chronic use of 20 mg/kg fluoxetine does not affect the amount of tooth movement, collagen neoformation, number of osteoclasts, or hyalinized areas and does not affect root resorption until the last day of orthodontic movement.
DOI: 10.6084/m9.figshare.21936700
title: Mahabalella pernambucana, a new hyphomycete from Brazil with notes on its phylogenetic positioning

description: ABSTRACT A new species of Mahabalella B. Sutton & S. D. Patil was isolated from decaying leaves of an unidentified plant, during a survey in the Charles Darwin Ecological Refuge in Igarassu, Pernambuco, Brazil, in June 2018. The new species is morphologically distinguishable from the other Mahabalella species by the size of their conidia, conidiogenous cells and setae. In this study, the morphological descriptions, illustrations and cultural characteristics for Mahabalella pernambucana are provided, as well as a key to species of this genus. Total DNA from the isolate was extracted, and four genes were partially sequenced (nLSU, ITS cluster, TEF1 alpha, and beta tubulin). Based on the nLSU analysis, the phylogenetic position of the new species was determined within the Sordariomycetes, Ascomycota, as a sister genus to Neotracylla, in the Tracyllaceae family.
DOI: 10.6084/m9.figshare.21936700.v1
title: Mahabalella pernambucana, a new hyphomycete from Brazil with notes on its phylogenetic positioning

description: ABSTRACT A new species of Mahabalella B. Sutton & S. D. Patil was isolated from decaying leaves of an unidentified plant, during a survey in the Charles Darwin Ecological Refuge in Igarassu, Pernambuco, Brazil, in June 2018. The new species is morphologically distinguishable from the other Mahabalella species by the size of their conidia, conidiogenous cells and setae. In this study, the morphological descriptions, illustrations and cultural characteristics for Mahabalella pernambucana are provided, as well as a key to species of this genus. Total DNA from the isolate was extracted, and four genes were partially sequenced (nLSU, ITS cluster, TEF1 alpha, and beta tubulin). Based on the nLSU analysis, the phylogenetic position of the new species was determined within the Sordariomycetes, Ascomycota, as a sister genus to Neotracylla, in the Tracyllaceae family.
DOI: 10.6084/m9.figshare.21936702.v1
title: Computed tomography analysis of fascial space involvement demonstrates correlations with laboratory tests, length of hospital stays and admission to the intensive care unit in odontogenic infections

description: Abstract Objectives: Odontogenic infections are frequent and can spread, leading to complications such as sepsis and the need for admission to an Intensive Care Unit (ICU). The purpose of this study was to perform a computed tomography analysis of the fascial space involvement and correlate with personal data, laboratory tests, length of hospital stays and admission to the ICU in patients with odontogenic infections who required hospitalization. Methods: Patients with odontogenic infections admitted between June 2017 and May 2018 were prospectively evaluated. The fascial spaces involved were studied using computed tomography with contrast. The possible correlations of tomographic findings with comorbidities, nutritional status, the causative tooth, laboratory tests, length of hospital stays and admission to the ICU were analyzed. Results: We identified 66 cases of odontogenic infections which were admitted in the period analyzed. The involvement of primary spaces (86.7%) predominated, followed by secondary ones (8.7%), and cervical (4.6%). The most frequently involved fascial spaces were submandibular (27.1%), buccal (20.8%), sublingual (18.3%), submental (16.7%), and others (17.1%). There were significant differences between laboratory tests (p &lt; 0.001), mean hospital stays (p &lt; 0.001), and admissions to the ICU (p &lt; 0.001) depending on the number of fascial spaces involved. There was no influence of comorbidities, nutritional status, or causative tooth on fascial space involvement. Conclusion: There was a relationship between greater involvement of fascial spaces assessed by computed tomography and higher values of laboratory tests, more extended hospitalization stays and admission to the ICU. Level of evidence: Level 2b.
DOI: 10.6084/m9.figshare.21936702
title: Computed tomography analysis of fascial space involvement demonstrates correlations with laboratory tests, length of hospital stays and admission to the intensive care unit in odontogenic infections

description: Abstract Objectives: Odontogenic infections are frequent and can spread, leading to complications such as sepsis and the need for admission to an Intensive Care Unit (ICU). The purpose of this study was to perform a computed tomography analysis of the fascial space involvement and correlate with personal data, laboratory tests, length of hospital stays and admission to the ICU in patients with odontogenic infections who required hospitalization. Methods: Patients with odontogenic infections admitted between June 2017 and May 2018 were prospectively evaluated. The fascial spaces involved were studied using computed tomography with contrast. The possible correlations of tomographic findings with comorbidities, nutritional status, the causative tooth, laboratory tests, length of hospital stays and admission to the ICU were analyzed. Results: We identified 66 cases of odontogenic infections which were admitted in the period analyzed. The involvement of primary spaces (86.7%) predominated, followed by secondary ones (8.7%), and cervical (4.6%). The most frequently involved fascial spaces were submandibular (27.1%), buccal (20.8%), sublingual (18.3%), submental (16.7%), and others (17.1%). There were significant differences between laboratory tests (p &lt; 0.001), mean hospital stays (p &lt; 0.001), and admissions to the ICU (p &lt; 0.001) depending on the number of fascial spaces involved. There was no influence of comorbidities, nutritional status, or causative tooth on fascial space involvement. Conclusion: There was a relationship between greater involvement of fascial spaces assessed by computed tomography and higher values of laboratory tests, more extended hospitalization stays and admission to the ICU. Level of evidence: Level 2b.
DOI: 10.6084/m9.figshare.21936703.v1
title: Age-dependent differences of the depth of olfactory fossa in children

description: Abstract Objective: With this radio-anatomical study, we aimed to describe the distribution of the depth of the olfactory fossa based on the Keros classification in the pediatric population in our region and to reduce complication rates by providing normative data. Methods: This was a retrospective study conducted with computed tomography imaging of the paranasal sinuses of 390 pediatric patients referred over a six-year period in Sakarya and Kocaeli University Faculty of Medicine. Patients were divided into 3 groups as 1–6, 6–12, and 12–18 years old. The depth of the olfactory fossa was measured and classified according to the Keros classification. The incidence of Keros asymmetries was also investigated. Results: The distribution of the depth of a total of 780 olfactory fossa according to the Keros classification was 24.7% Keros I, 65.9% Keros II, and 9.4% Keros III. When the groups were evaluated with each other and within each group, it was seen that the prevalence of Keros I type was significantly higher in the first group (p &lt; 0.05), and the prevalence of Keros type II was significantly higher in the second and third groups (p &lt; 0.05). Apart from this, the number of Keros type III increased in the third group compared to the first two groups and showed a statistically significant difference (p &lt; 0.05). Among all patients, asymmetry of the olfactory fossa was detected in 29 patients (7.4%). Although the number of olfactory fossa asymmetry was low in group I, it was not significantly different between the groups (p &gt; 0.05). Conclusion: In our study, high Keros I rate and low Keros III rate in children aged -6 were remarkable. Especially for children under the age of six, questions arise about the validity of the Keros classification. More detailed studies in larger populations, in different ethnicities, and with various age groups are needed. Level of evidence: Level 3.
DOI: 10.6084/m9.figshare.21936703
title: Age-dependent differences of the depth of olfactory fossa in children

description: Abstract Objective: With this radio-anatomical study, we aimed to describe the distribution of the depth of the olfactory fossa based on the Keros classification in the pediatric population in our region and to reduce complication rates by providing normative data. Methods: This was a retrospective study conducted with computed tomography imaging of the paranasal sinuses of 390 pediatric patients referred over a six-year period in Sakarya and Kocaeli University Faculty of Medicine. Patients were divided into 3 groups as 1–6, 6–12, and 12–18 years old. The depth of the olfactory fossa was measured and classified according to the Keros classification. The incidence of Keros asymmetries was also investigated. Results: The distribution of the depth of a total of 780 olfactory fossa according to the Keros classification was 24.7% Keros I, 65.9% Keros II, and 9.4% Keros III. When the groups were evaluated with each other and within each group, it was seen that the prevalence of Keros I type was significantly higher in the first group (p &lt; 0.05), and the prevalence of Keros type II was significantly higher in the second and third groups (p &lt; 0.05). Apart from this, the number of Keros type III increased in the third group compared to the first two groups and showed a statistically significant difference (p &lt; 0.05). Among all patients, asymmetry of the olfactory fossa was detected in 29 patients (7.4%). Although the number of olfactory fossa asymmetry was low in group I, it was not significantly different between the groups (p &gt; 0.05). Conclusion: In our study, high Keros I rate and low Keros III rate in children aged -6 were remarkable. Especially for children under the age of six, questions arise about the validity of the Keros classification. More detailed studies in larger populations, in different ethnicities, and with various age groups are needed. Level of evidence: Level 3.
DOI: 10.6084/m9.figshare.21936705
title: The promising role of Gelsolin expression to predict survival in patients with squamous cell carcinoma of the larynx

description: Abstract Introduction: Gelsolin protein has important cellular functions, including cell motility and apoptosis. Altered gelsolin expression has been reported in several types of neoplasms, but clinicopathological features of gelsolin are currently unclear in patients with laryngeal squamous cell carcinoma. Objectives: Our aim is to investigate the clinicopathological significance of gelsolin as a prognostic biomarker for laryngeal squamous cell carcinoma. Methods: Tissue specimens from 168 patients with laryngeal squamous cell carcinoma were immunohistochemically assessed for the Gelsolin expression. Prognostic significance of Gelsolin and its interaction with clinical parameters was analysed. Results: Gelsolin expression was confirmed in 70.2% of cases. Gelsolin expression is significantly associated with tumor stage, tumor grade, and locoregional recurrence. Kaplan-Meier survival curves revealed that Gelsolin expression inversely correlated with both disease-specific and overall survival. Conclusion: This research is the first to demonstrate that Gelsolin expression is associated with a poor prognosis in laryngeal squamous cell carcinoma. Gelsolin is a novel promising biomarker and attractive target for the treatment of laryngeal squamous cell carcinoma.
DOI: 10.6084/m9.figshare.21936705.v1
title: The promising role of Gelsolin expression to predict survival in patients with squamous cell carcinoma of the larynx

description: Abstract Introduction: Gelsolin protein has important cellular functions, including cell motility and apoptosis. Altered gelsolin expression has been reported in several types of neoplasms, but clinicopathological features of gelsolin are currently unclear in patients with laryngeal squamous cell carcinoma. Objectives: Our aim is to investigate the clinicopathological significance of gelsolin as a prognostic biomarker for laryngeal squamous cell carcinoma. Methods: Tissue specimens from 168 patients with laryngeal squamous cell carcinoma were immunohistochemically assessed for the Gelsolin expression. Prognostic significance of Gelsolin and its interaction with clinical parameters was analysed. Results: Gelsolin expression was confirmed in 70.2% of cases. Gelsolin expression is significantly associated with tumor stage, tumor grade, and locoregional recurrence. Kaplan-Meier survival curves revealed that Gelsolin expression inversely correlated with both disease-specific and overall survival. Conclusion: This research is the first to demonstrate that Gelsolin expression is associated with a poor prognosis in laryngeal squamous cell carcinoma. Gelsolin is a novel promising biomarker and attractive target for the treatment of laryngeal squamous cell carcinoma.
DOI: 10.6084/m9.figshare.21936708
title: Airway management following head and neck microvascular reconstruction: is tracheostomy mandatory?

description: Abstract Objectives: Airway management following maxillofacial microvascular reconstruction is a fundamental part of the perioperative management. In oral cavity microvascular reconstruction, the airway is potentially compromised by airway edema, flap edema or bulkiness, hematoma formation, or upper airway sequelae from surgery. Classical teaching advocates elective tracheostomy in patients undergoing maxillofacial free flap reconstruction, while others keep patients intubated overnight (delayed extubation). The optimal method for perioperative airway management is still debated. This study aim was to evaluate the morbidity associated with elective tracheostomy in patients undergoing maxillofacial microvascular reconstruction and to recognize those patients who can avoid elective tracheostomy. Methods: Retrospective review of patients who underwent maxillofacial microvascular free flap reconstruction, between November 1st 2010 and October 31st 2019 in our center. Results: One-hundred and nine patients underwent microvascular reconstruction in the maxillofacial region. Sixty-one patients underwent an elective tracheostomy upon the primary surgery. Forty-eight patients were left intubated overnight. Seven patients underwent a late tracheostomy which was performed upon a neck re-exploration for postoperative complications, except for one patient which was due to failed extubation attempt. Conclusions: Our results suggest, the routine use of elective tracheostomy in maxillofacial microvascular free flap reconstruction is unnecessary. Elective tracheostomy should be considered on case-to-case basis. Level of evidence: 4. HIGHLIGHTS Airway management following maxillofacial microvascular reconstruction is complex. Lack of consensus exists regarding the optimal airway management perioperatively. Routine use of tracheostomy is unnecessary. Tracheostomy should be considered on a case-to-case basis.
DOI: 10.6084/m9.figshare.21936708.v1
title: Airway management following head and neck microvascular reconstruction: is tracheostomy mandatory?

description: Abstract Objectives: Airway management following maxillofacial microvascular reconstruction is a fundamental part of the perioperative management. In oral cavity microvascular reconstruction, the airway is potentially compromised by airway edema, flap edema or bulkiness, hematoma formation, or upper airway sequelae from surgery. Classical teaching advocates elective tracheostomy in patients undergoing maxillofacial free flap reconstruction, while others keep patients intubated overnight (delayed extubation). The optimal method for perioperative airway management is still debated. This study aim was to evaluate the morbidity associated with elective tracheostomy in patients undergoing maxillofacial microvascular reconstruction and to recognize those patients who can avoid elective tracheostomy. Methods: Retrospective review of patients who underwent maxillofacial microvascular free flap reconstruction, between November 1st 2010 and October 31st 2019 in our center. Results: One-hundred and nine patients underwent microvascular reconstruction in the maxillofacial region. Sixty-one patients underwent an elective tracheostomy upon the primary surgery. Forty-eight patients were left intubated overnight. Seven patients underwent a late tracheostomy which was performed upon a neck re-exploration for postoperative complications, except for one patient which was due to failed extubation attempt. Conclusions: Our results suggest, the routine use of elective tracheostomy in maxillofacial microvascular free flap reconstruction is unnecessary. Elective tracheostomy should be considered on case-to-case basis. Level of evidence: 4. HIGHLIGHTS Airway management following maxillofacial microvascular reconstruction is complex. Lack of consensus exists regarding the optimal airway management perioperatively. Routine use of tracheostomy is unnecessary. Tracheostomy should be considered on a case-to-case basis.
DOI: 10.6084/m9.figshare.21936711
title: Student satisfaction and self-confidence in realistic simulation and the experience of knowledge perpetuation

description: Abstract: Introduction: The structure of educational methods is frequently renewed, using different available tools, according to the National Curriculum Guidelines. One of these, the realistic simulation (RS) methodology, is used to create proximity between the student and the real everyday life in a monitored environment, which provides room for error, but not with an actual patient. However, measuring meaningful learning is a complex task and support scales can be used. Based on this challenge, can the perpetuation of knowledge among students from different semesters using the RS tool add knowledge? Objectives: To explain the use of RS among medical students; to compare satisfaction and self-confidence indices in relation to RS using a scale, specifically in CPR (Cardiopulmonary Resuscitation), before and after the learning intervention among students from different semesters; to know the students’ learning process through the in-person teaching post-performance questionnaire. Method: This was a quasi-experimental study with 86 medical students from a private institution, with data collection was carried out in three stages, namely: study guidelines, scenario practice and perpetuation of knowledge to other students. Two questionnaires and an evaluation scale were used as tools and, for comparison, the relative and absolute frequencies, Cronbach’s alpha and the non-parametric Mann-Whitney test were used. Results: Cronbach’s alpha was considered high and the nonparametric test resulted in values between 3.81 and 4.91, indicating agreement in satisfaction and self-confidence in learning, with a significant difference in the answers: I liked the way my teacher taught using the simulation; I am confident that I have mastered the content of the simulation activity to which my teacher introduced me and I know how to use simulation activities to learn skills. Regarding the perpetuation of learning, its fixation and its relevance in training, all students also agreed that 6% still did not consider themselves ready to perform CPR. Conclusion: The study proposal proved to be effective in improving learning and perpetuating knowledge among students.
DOI: 10.6084/m9.figshare.21936711.v1
title: Student satisfaction and self-confidence in realistic simulation and the experience of knowledge perpetuation

description: Abstract: Introduction: The structure of educational methods is frequently renewed, using different available tools, according to the National Curriculum Guidelines. One of these, the realistic simulation (RS) methodology, is used to create proximity between the student and the real everyday life in a monitored environment, which provides room for error, but not with an actual patient. However, measuring meaningful learning is a complex task and support scales can be used. Based on this challenge, can the perpetuation of knowledge among students from different semesters using the RS tool add knowledge? Objectives: To explain the use of RS among medical students; to compare satisfaction and self-confidence indices in relation to RS using a scale, specifically in CPR (Cardiopulmonary Resuscitation), before and after the learning intervention among students from different semesters; to know the students’ learning process through the in-person teaching post-performance questionnaire. Method: This was a quasi-experimental study with 86 medical students from a private institution, with data collection was carried out in three stages, namely: study guidelines, scenario practice and perpetuation of knowledge to other students. Two questionnaires and an evaluation scale were used as tools and, for comparison, the relative and absolute frequencies, Cronbach’s alpha and the non-parametric Mann-Whitney test were used. Results: Cronbach’s alpha was considered high and the nonparametric test resulted in values between 3.81 and 4.91, indicating agreement in satisfaction and self-confidence in learning, with a significant difference in the answers: I liked the way my teacher taught using the simulation; I am confident that I have mastered the content of the simulation activity to which my teacher introduced me and I know how to use simulation activities to learn skills. Regarding the perpetuation of learning, its fixation and its relevance in training, all students also agreed that 6% still did not consider themselves ready to perform CPR. Conclusion: The study proposal proved to be effective in improving learning and perpetuating knowledge among students.