cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.24967941.v4
title: Supplementary Material for: HPA1-29w genotyping and the foundation for the platelet apheresis registry in Jiangsu province of China by MassARRAY spectrometry

description: Introduction: This study aimed to investigate the allele frequencies of the human platelet antigens HPA-1-29w system in Jiangsu (China) and establish the platelet apheresis registry in blood donors. Methods: HPA genotyping was performed using the MassARRAY iPLEX® platform. Allele and genotype frequencies were estimated by direct counting and tested for Hardy–Weinberg equilibrium. The transfusion mismatch probability was calculated for every HPA specificity. Results: The HPA allele frequencies in the Jiangsu Han population of HPA-1b, -2b, -3b, -4b, -5b, -6b, -11b, -15b, and -21b were 0.0055, 0.0530, 0.4116, 0.0015, 0.0155, 0.0162, 0.0003, 0.5317, and 0.0070, respectively, in which a heterozygote of HPA-11a/b was first detected in China. Only allele a was detected for HPA-7-10w、-12-14w、-16-20w and -22-29w quasi-systems. The highest mismatch rate of HPA genes in 1640 platelet donors was the HPA-15 system, followed by the HPA-3 system with a rate of 37.4% and 36.71%, respectively. Conclusion: China’s largest-scale platelet registry of HPA-1-29w has been explored. The MassARRAY platform may help to found the platelet apheresis registry which would be useful to provide matching platelets and lead to a more accurate, effective, and safe transfusion for patients with platelet therapy.
DOI: 10.17632/b82v4tm4xs
title: CONSTRUCTIVISMO Y EDUCACIÓN

description: Para estudiar e intervenir en el contexto educativo formal, es necesario contar con marcos teóricos pensados para ese contexto. La vertiente educativa constructivista ofrece un marco interpretativo desde el cual es posible estudiar el quehacer del docente, comprender el rol del estudiante y el lugar que ocupa el conocimiento y el aprendizaje en el espacio del aula. En esta nota de clase se abordan los principios en los que se fundamenta una mirada constructivista del aprendizaje.
Además de la presentación, se incluye en esta nota de clase el texto en el que se fundamente la clase: “Constructivismo y educación. La concepción constructivista de la enseñanza y el aprendizaje” de César Coll y el taller que los estudiantes deben preparar antes de la clase.
DOI: 10.17632/shrtfdc4w6
title: Data for: Is litter decomposition enhanced in species mixtures? A meta-analysis
DOI: 10.6084/m9.figshare.27620196.v3
title: Results files for Hydrodynamics of In-stream Leaky Barriers for Natural Flood Management

description: Flow around leaky barriers (LB) composed of three cylindrical logs were investigated using large-eddy simulation. The main LB configuration considered vertically aligned logs, with other layouts inclined at 15$^\circ$, 30$^\circ$, and 45$^\circ$ in the upstream and downstream directions. These are the tecturb files of the mean quantities for all cases.
DOI: 10.6084/m9.figshare.28416212.v1
title: Supplemental information 2.xlsx

description: Tamdy virus (TAMV) is one of a number of zoonotic tick-borne bunyaviruses that have emerged as global public health threats in recent decades. To date, however, TAMV pathogenesis remains poorly understood. In the present study, we have established different mouse infection models to enable investigation of TAMV pathogenesis. Adult BALB/c mice did not exhibit obvious clinical symptoms or signs post-TAMV infection. In contrast, adult type I interferon receptor knock-out (IFNAR<sup>-/-</sup>) A129 mice were found to be susceptible to high-doses of TAMV (6×10<sup>2</sup> and 6×10<sup>4</sup> FFU) and all developed severe clinical symptoms and signs, including weight loss, immobility, and reached the euthanasia criteria at 4/5 days post-infection (dpi). Viral RNA was detected in peripheral blood and different tissues (heart, liver, spleen, lung, kidney, intestine,and brain) of the infected adult A129 mice, with the highest viral loads in the liver (approximately 10<sup>8.3</sup> copies/μL). Pathological examination also revealed severe liver damage in the infected A129 mice. In addition, the titers of TAMV-specific IgM and IgG antibodies increased rapidly 4-5 dpi. Analysis of cytokine and chemokine expression changes demonstrated that type I IFN may play an important role in the host defense against viral infection by enhancing IL-10 production. Gene ontology and KEGG analyses showed that liver injury may be associated with virus-induced expression of inflammatory cytokinesand chemokines.Together, we have investigated TAMV pathogenesis using immunocompetent and immunocompromised mouse models, which should help facilitate the development of TAMV-specific antivirals and vaccines.
DOI: 10.6084/m9.figshare.21757880.v1
title: AMAW-genomes-used

description: Genomes used in the publication of AMAW.
DOI: 10.6084/m9.figshare.28299497.v1
title: CosMx 6000-plex PDAC dataset

description: 6000plex CosMx data from PDAC tumors, as used in Figure 3 of Danaher et al. 2025, "InSituCor: exploring spatially correlations among genes conditional on the cell type landscape".
DOI: 10.17632/n4yv24kp8w
title: Data on NOS items validation

description: An instrument is devised to measure Nature of Science integration. The title of the instrument is Nature of Science Competence Template (NCT). It guides the training and instruction of science educators, teachers and preservice teachers on integration of NOS in the classroom. The instrument was validated by 11 experts with over five years experience in science pedagogical practices. The software for data analysis in this case was R package. t-test, Bonferroni, correlation, Cronbach Alpha, tables, figures and chats are contained in the folder. Ethical clearance was obtained for the research at the University of the Free State, South Africa.
DOI: 10.17632/22rgdy6cbv
title: Translation and Cross Cultural Adaptation, Reliability and Validity of Hindi version of Lower Extremity Functional Scale

description: The database shows the characteristics for the reliability and validity testing
DOI: 10.6084/m9.figshare.14338760.v1
title: Kurokawa+2021_Asteroids.zip

description: Observation and modeling data used in the paper: Kurokawa et al. (2021) Distant formation and differentiation of outer main belt asteroids and carbonaceous chondrites' parent bodie.
DOI: 10.6084/m9.figshare.7420532.v1
title: Stability indicating RP-HPLC method development and validation of cefepime and amikacin in pure and pharmaceutical dosage forms

description: A simple, accurate, isocratic stability indicating RP-HPLC method was developed for the determination of cefepime and amikacin in Pure and its pharmaceutical formulations. The method consists of methanol: acetonitrile:acetate buffer 75:20:05 (v/v) mobile phase at pH 5.1 with C18 column as stationary phase. The flow rate and detection wave length were 1.0 mL/min and 212 nm respectively. The linearity range for the method was found to be 2.5-25 µg/mL for amikacin and 10-100 µg/mL cefepime respectively. The developed method was validated as per ICH guidelines and the results of all the validation parameters were well within their acceptance values. Also the forced degradation studies were conducted with standard drugs. Degradation products formed during the different stress conditions were separated from both drugs. This validated method was applied for the simultaneous estimation of cefepime and amikacin in commercially available formulation sample.
DOI: 10.17632/f23v4y62hd
title: Secukinumab is effective and safe in the treatment of recalcitrant palmoplantar psoriasis and palmoplantar pustular psoriasis in a daily practice setting.

description: Background: Palmoplantar psoriasis (PP) and palmoplantar pustular psoriasis (PPPP) are frequently recalcitrant to treatment. Currently, we have limited information from guidelines for their management.
Objective: To study drug effectiveness, safety and persistence as well as quality of life in patients with PP and PPPP treated with secukinumab (SEK) in real clinical practice.
Methods: Retrospective, observational, non-controlled, multicenter cohort, long-term study of patients with moderate-to-severe PP and PPPP (ppIGA/pppIGA score ≥3) treated with SEK under daily practice conditions between January 2014-July 2020. 
Results:  Seventy-two patients (55 PP, 17 PPPP) were included. A 56.36% and 52.94% of PP and PPPP patients, respectively, achieved ppIGA/pppIGA response scores of 0/1 or a reduction of at least 2 points on the ppIGA/pppIGA scale from baseline in the 24-month follow-up. We found statistically significant differences in ppIGA at 12 months between naïve subjects and patients with prior biologic therapy, with greater effectiveness in naïve patients. Mean drug survival for PP and PPPP patients were 12.7 and 13.4 months; respectively.
Limitations: Those derived from the retrospective and multicenter nature of the study.
Conclusion: Secukinumab is a safe, fast and effective treatment alternative for some patients with PP and PPPP refractory to previous systemic or biologic treatments.
DOI: 10.6084/m9.figshare.11323106
title: Supplementary Material for: Activation of a Classic Hunger Circuit Slows Luteinizing Hormone Pulsatility

description: <b><i>Introduction:</i></b> The central regulation of fertility is carefully coordinated with energy homeostasis, and infertility is frequently the outcome of energy imbalance. Neurons in the hypothalamus expressing neuropeptide Y and agouti-related peptide (NPY/AgRP neurons) are strongly implicated in linking metabolic cues with fertility regulation. <b><i>Objective:</i></b> We aimed here to determine the impact of selectively activating NPY/AgRP neurons, critical regulators of metabolism, on the activity of luteinizing hormone (LH) pulse generation. <b><i>Methods:</i></b> We employed a suite of in vivo optogenetic and chemogenetic approaches with serial measurements of LH to determine the impact of selectively activating NPY/AgRP neurons on dynamic LH secretion. In addition, electrophysiological studies in ex vivo brain slices were employed to ascertain the functional impact of activating NPY/AgRP neurons on gonadotropin-releasing hormone (GnRH) neurons. <b><i>Results:</i></b> Selective activation of NPY/AgRP neurons significantly decreased post-castration LH secretion. This was observed in males and females, as well as in prenatally androgenized females that recapitulate the persistently elevated LH pulse frequency characteristic of polycystic ovary syndrome (PCOS). Reduced LH pulse frequency was also observed when optogenetic stimulation was restricted to NPY/AgRP fiber projections surrounding GnRH neuron cell bodies in the rostral preoptic area. However, electrophysiological studies in ex vivo brain slices indicated these effects were likely to be indirect. <b><i>Conclusions:</i></b> These data demonstrate the ability of NPY/AgRP neuronal signaling to modulate and, specifically, reduce GnRH/LH pulse generation. The findings suggest a mechanism by which increased activity of this hunger circuit, in response to negative energy balance, mediates impaired fertility in otherwise reproductively fit states, and highlight a potential mechanism to slow LH pulsatility in female infertility disorders, such as PCOS, that are associated with hyperactive LH secretion.
DOI: 10.6084/m9.figshare.28524998.v2
title: IHF/HU phylogenetic analysis dataset

description: This consists of the dataset for the publication "The evolution of sequence specificity in a DNA binding protein family"
DOI: 10.17632/m2tjd73b99
title: Reference Evapotranspiration

description: Reference evapotranspiration database for basins in the Center-South region of Espírito Santo-BR
DOI: 10.17632/thkvyvhjws
title: Murine maternal microbiome modifies adverse effects of protein undernutrition on offspring neurobehavior

description: Protein undernutrition results in impaired growth and neurobehavioral development in children. However, the impact of timing, environmental factors, and maternal versus neonatal influences are unclear. Here, using a mouse model of fetal growth restriction where maternal protein intake is limited during pregnancy, we show that adult offspring exhibit cognitive and anxiety-like behavioral abnormalities. Cross-fostering newborn mice to dams previously exposed to either low protein or standard diet reveals that behavioral impairments in adult offspring require diet-induced conditioning of both fetal development and maternal peripartum physiology. Maternal gut microbiome diversity is reduced, maternal immune, milk, and serum metabolomic profiles are altered, and widespread changes in fetal brain transcriptomic and metabolomic profiles are observed, including subsets of microbiome-dependent metabolites. Finally, we show that dams treated with a cocktail of ten diet- and microbiome-dependent metabolites results in differential effects on fetal development and postnatal behavior. Our study highlights the impact of prenatal maternal protein undernutrition on offspring neurobehavioral trajectories and the role of the maternal microbiome.
DOI: 10.6084/m9.figshare.1200131.v1
title: Clashach Sandstone

description: Micro-Computed Tomography (micro-CT) segmented image of Clashach Sandstone. The micro-CT image is segmented according to the variation of grey values between grains (bright- 255 grey value) and pores (dark- 0 grey value) using the watershed segmentation algorithm in the Avizo software. Details of the images (voxel resolution and image size) is present as a text file. The image can be visualized in visualization software such as Fiji ((http://fiji.sc/Fiji) or Avizo. If you utilise this in a scientific publication then please mention in the acknowledgements that this data is courtesy of Qatar Carbonates and Carbon Storage Research Centre, Imperial College London. For more information, please contact Saurabh M Shah at saurabh.shah10@imperial.ac.uk or Edo S Boek at e.boek@imperial.ac.uk
DOI: 10.17632/5chmzk7zvf
title: Atezolizumab Treatment for TNBC

description: Despite remarkable success of immune checkpoint blockade with chemotherapy, their efficacies in triple negative breast cancer (TNBC) are controversial. We utilized a non-invasive metabolomic and proteomic approach to comprehensively profile serum metabolites and proteins in 20 advanced TNBC patients treated with paclitaxel or its combination with atezolizumab, an antibody against programmed cell death protein 1 ligand 1(PDL1). In total, 1441 metabolites and 1254 proteins were quantified in patient sera at baseline, 4 weeks after treatment initiation, and disease progression. We found that high levels of lipids, tricarboxylic acid cycle (TCA) intermediates and free fatty acids at baseline could predict effective responses to the combination therapy. Notably, lipids exhibited dramatic decline following atezolizumab treatment, but instead showed increase after paclitaxel treatment. Our data point to new ways of targeting metabolic reprogramming to improve the efficacy of cancer immune intervention therapy.
DOI: 10.17632/bj967rwhjh
title: Exploring structural, electronic, thermal and mechanical properties of novel C60-based fullerene two-dimensional networks by first-principles and machine learning

description: Data for the manuscript
Lattices.zip folder includes the 2D-Lattices, PC-Lattices and 1D-Lattices folders with the atomic structures in VASP POSCAR format for 2D, Porous-Carbon and 1D C60-based lattices, respectively. Find 1D.jpg, 2D.jpg and PC.jpg for the illustration of atomic structures.
Electronic&Phononic.zip folder includes the electronic and phononic properties of every structure. Note that HIGH_SYMMETRY_POINTS for every structure are obtained using the VASPKIT package. 
ThermalStability.zip folder includes the AIMD results conducted at 1000 K for the analysis of thermal stability of every structure.
Training-Data-MTPs.zip folder includes the complete AIMD training datasets (find: “**-AIMD.cfg”), and also the fitted MTPs for the evaluation of mechanical and thermal conductivity of 2D, Porous-Carbon and 1D C60-based lattices (find: “**-p.mtp”).
DOI: 10.17632/3d6w948vf5
title: Structural mechanism of phosphatidylglycerol phosphate biosynthesis at the membrane-cytosol interface

description: the original data of "Structural mechanism of phosphatidylglycerol phosphate biosynthesis at the membrane-cytosol interface"
DOI: 10.17632/6czn6r52s2
title: The Impact of Gadgets on Elementary Students' Learning: Data from a 2024 study

description: This dataset includes the gadgets whose integration into education has grown excessively, raising questions about their impact on the students’ learning for the younger learners. This systematic literature review examines studies that were published between 2010 and 2024 that explore both the benefits and drawbacks of gadget use in elementary education. Positive impacts include improved engagement and personalized learning experiences through interactive educational applications. However, findings also indicate potential drawbacks, such as reduced attention span, increased distraction, and challenges to physical and social development due to prolonged screen time. This review highlights the importance of moderation and structured integration of gadgets within the classroom to maximize educational benefits while minimizing potential downsides. Recommendations for future research include longitudinal studies to explore the long-term effects of gadget use on academic and developmental outcomes in children.
DOI: 10.6084/m9.figshare.5120743.v1
title: Supplementary Material for: Regulatory Effect of Common Promoter Polymorphisms on the Expression of the <i>11</i>β<i>-Hydroxysteroid Dehydrogenase Type 1 </i>Gene

description: <i>Background/Aims:</i> Glucocorticoids play an important role in the pathogenesis of obesity and insulin resistance. 11β-hydroxysteroid dehydrogenase type 1 (HSD11B1), which converts inactive cortisone to active cortisol, has become an emerging therapeutic target for type 2 diabetes mellitus and obesity. In this study, we examined the association between <i>HSD11B1 </i>polymorphisms and type 2 diabetes and metabolic phenotypes in Koreans. <i>Methods:</i> We sequenced all exons including exon-intron boundaries and the promoter region of the <i>HSD11B1 </i>gene. Of 8 polymorphisms identified, we selected 4 common single-nucleotide polymorphisms (<i>g.–19835G</i>&gt;<i>A, g.–19609A</i>&gt;<i>G, g.+27447G</i>&gt;<i>C </i>and<i> g.+27810C</i>&gt;<i>T</i>) based on location, linkage disequilibrium and frequency and which were genotyped in 757 subjects with type 2 diabetes and 644 nondiabetic subjects. <i>Results:</i> There was no association between the 4 common polymorphisms of <i>HSD11B1 </i>and type 2 diabetes. <i>g.–19835G</i>&gt;<i>A </i>and<i> g.–19609A</i>&gt;<i>G</i> showed modest associations with fasting plasma glucose and body mass index but the significance of these associations was lost after adjustment for multiple comparison. With regard to promoter polymorphisms in the <i>HSD11B1</i> gene, a haplotype construct carrying both <i>g.–19835A</i> and <i>g.–19609G </i>showed significantly decreased promoter activity compared to other common haplotype constructs. <i>Conclusion:</i> The variations in <i>HSD11B1</i> were not associated with susceptibility to type 2 diabetes or metabolic phenotypes in Koreans. However, the common promoter variants of the gene might exert a polymorphic regulatory effect on HSD11B1 expression.
DOI: 10.17632/xzd7hj5yk6
title: Combined characterization of a plasma jet: FTIR, chemical surveys and antibacterial effect

description: Dataset related to the paper "Combined characterization of a plasma jet: FTIR, chemical surveys and antibacterial effect", submitted for publication on Plasma Chemistry and Plasma Processing
DOI: 10.6084/m9.figshare.14479503.v1
title: CrossPerformancePowerPrediction

description: We have collected performance and power datasets for 6 benchmark applications; mser, tracking, svm and stitch from SD-VBS benchmark and sha and dijkstra from MiBench benchmark from simulation systems built-in Gem5 simulator with emulation mode as well as from physical systems.<br>Simulation Systems Performance and Power Dataset:We have built 475 simulation systems in the Gem5 simulator using emulation mode by collecting nine hardware features cpu clock speed, instriction-set-architecture (ISA), cores, L1 cache size, L2 cache size, L3 cache size, memory type, memory access speed and memory size from real systems available in the market today. We have executed each of the 6 benchmark applications on each of the 475 simulation systems to collect actual runtime along with hardware features. We have utilized the McPAT to collect power consumption for each application execution on Gem5 simulation systems. The hardware features, performance (Runtime) and Power is available in files /benchmark_algo/%application%/%application%_power.csv e.g. for mser it is available at benchmark_algo/mser/mser_power.csv, etc.<br>Physical Systems Performance and Power Dataset:We have selected 4 physical systems for our cross performance power prediction experiments. We first have collected hardware feature values from each of the four systems using the dmidecode utility. We have modified each of the 6 benchmark applications' source code to integrate PAPI-API to collect power consumption. PAPI-API uses Intel's RAPL to read machine status registers (MSRs) to collect power consumption. We have executed modified versions of each benchmark application on each physical system to collect runtime and power consumption from benchmark logs. The hardware features, performance (Runtime) and Power are available in files /benchmark_algo/%application%/%application%_power_lab.csv e.g. for mser it is available at benchmark_algo/mser/mser_power_lab.csv, etc.<br>Performance and Power Dataset from Gem5 Systems with Hardware Features of Physical Systems:For validation purposes, we have to build Gem5 systems with identical hardware feature values as the physical systems. We have collected performance power for each benchmark application by executing each of these systems. The files /benchmark_algo/%application%/Gem5LabSystemConfigs.csv under each application folder consists of performance (runtime) and power for the Gem5 systems with features of physical systems.
DOI: 10.6084/m9.figshare.27985748.v1
title: Experimental and Clinical data.zip

description: <b></b>Myelodysplastic neoplasms (MDS) are heterogeneous neoplasms that originate from bone marrow (BM) hematopoietic stem cells. S100A8 and S100A9 (S100A8/9) are crucial molecules involved in the innate immune pathogenesis of MDS. This study aimed to explore the value of these molecules in the differential diagnosis of MDS, and analyze the correlations between their concentrations and clinical characteristics.
DOI: 10.6084/m9.figshare.4214283.v1
title: UMA_ADL_FALL_Dataset.zip

description: The files contain the mobility traces generated by a group of 17 experimental subjects that emulated a set of predetermined ADL (Activities of Daily Life) and falls. The traces are aimed at evaluating fall detection algorithms.Several video clips describing the performed movements are also included.
DOI: 10.17632/ht4h95h7cm
title: Physical attraction measured by use of a body figure scale in an age of changing body ideals: An age discriminated sample from an Australian city.

description: There is a substantial body of research that uses figure rating scales for personal body image assessment and satisfaction where typically women self-identify as heavier than what they wish to be, and men self-identify as less muscular than what they wish to be. The aim of this research was to determine the difference in attractiveness of physical body image by age of men and women using figure rating scales. It was hypothesised that younger age groups are more likely to identify more muscular figures as more attractive. Although the results of this study did not support the hypothesis, women were found to identify thinner images of women as more attractive to men; and men were found to identify more muscular images of men as more attractive to women. These findings have implications for clinical treatments related to body image and eating disorders.