cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.5281/zenodo.5914128
title: Target deconvolution of the HDAC pharmacopoeia highlights MBLAC2 as a common off-target

description: This dataset contains the untargeted lipidomics data for the publication Lechner et al. 2022 "Target deconvolution of the HDAC pharmacopoeia highlights MBLAC2 as a common off-target". The dataset has also been submitted to MetaboLight repository with ID "MTBLS3557". Please refer to the MetaboLight repository for the most up-to-date datasets. Publication abstract: Histone deacetylase (HDAC) targeting drugs have entered the pharmacopoeia in the 2000s. However, some enigmatic phenotypes suggest off-target engagement. Here, we developed a quantitative chemical proteomics assay using immobilized HDAC inhibitors and mass spectrometry that we deployed to establish the target landscape of 53 drugs. The assay covers 9 of the 11 human zinc dependent HDACs, questions the reported selectivity of some widely-used molecules, notably for HDAC6, and delineates how the composition of HDAC complexes influences drug potency. Unexpectedly, metallo-beta-lactamase domain-containing protein 2 (MBLAC2) featured as a frequent off-target of hydroxamate drugs. This poorly characterized palmitoyl-CoA hydrolase is inhibited by 24 HDAC inhibitors at low nM potency. MBLAC2 enzymatic inhibition and knock down led to the accumulation of extracellular vesicles. Given the importance of extracellular vesicle biology in neurological diseases and cancer, this HDAC-independent drug effect may qualify MBLAC2 as a target for drug discovery.
DOI: 10.5281/zenodo.5914127
title: Target deconvolution of the HDAC pharmacopoeia highlights MBLAC2 as a common off-target

description: This dataset contains the untargeted lipidomics data for the publication Lechner et al. 2022 "Target deconvolution of the HDAC pharmacopoeia highlights MBLAC2 as a common off-target". The dataset has also been submitted to MetaboLight repository with ID "MTBLS3557". Please refer to the MetaboLight repository for the most up-to-date datasets. Publication abstract: Histone deacetylase (HDAC) targeting drugs have entered the pharmacopoeia in the 2000s. However, some enigmatic phenotypes suggest off-target engagement. Here, we developed a quantitative chemical proteomics assay using immobilized HDAC inhibitors and mass spectrometry that we deployed to establish the target landscape of 53 drugs. The assay covers 9 of the 11 human zinc dependent HDACs, questions the reported selectivity of some widely-used molecules, notably for HDAC6, and delineates how the composition of HDAC complexes influences drug potency. Unexpectedly, metallo-beta-lactamase domain-containing protein 2 (MBLAC2) featured as a frequent off-target of hydroxamate drugs. This poorly characterized palmitoyl-CoA hydrolase is inhibited by 24 HDAC inhibitors at low nM potency. MBLAC2 enzymatic inhibition and knock down led to the accumulation of extracellular vesicles. Given the importance of extracellular vesicle biology in neurological diseases and cancer, this HDAC-independent drug effect may qualify MBLAC2 as a target for drug discovery.
DOI: 10.11570/16.0003
title: The JCMT Gould Belt Survey: A First Look at Dense Cores in Orion B'
title: The JCMT Gould Belt Survey: A First Look at Dense Cores in Orion B

description: This contains data and other information related to the publication 'The JCMT Gould Belt Survey: A First Look at Dense Cores in Orion B' by H. Kirk et al.
DOI: 10.11570/15.0002
title: The JCMT Gould Belt Survey: evidence for radiative hearing in Serpens MWC 297 and its influence on local star formation
title: The JCMT Gould Belt Survey

description: This directory contains data products from the JCMT Gould Belt survey published in Rumble et al., MNRAS, April 1, 2015, 448 (2),1551, 10.1093/mnras/stu2695. If you make use of these data products we request that you acknowledge their origin in the JCMT GBS and cite this paper.
DOI: 10.11570/15.0001
title: The JCMT Gould Belt Survey: First results from the SCUBA-2 observations of the Ophiuchus molecular cloud and a virial analysis of its prestellar core population
title: The JCMT Gould Belt Survey

description: This contains data, plots, and information of observations from the JCMT Gould Belt Survey
DOI: 10.11570/16.0008
title: The JCMT Gould Belt Survey: Dense Core Clusters in Orion A
title: The JCMT Gould Belt Survey: Dense Core Clusters in Orion A

description: This contains data and other information related to the publication 'The JCMT Gould Belt Survey: Dense Core Clusters in Orion A, Astrophysical Journal 2016
DOI: 10.11570/16.0005
title: The JCMT and Herschel Gould Belt Surveys: A comparison of SCUBA-2 and Herschel data of dense cores in the Taurus dark cloud L1495

description: This contains data and other information related to the publication 'The JCMT and Herschel Gould Belt Surveys: A comparison of SCUBA-2 and Herschel data of dense cores in the Taurus dark cloud L1495' MNRAS, 2016, 10.1093/mnras/stw1978
DOI: 10.11570/16.0007
title: The JCMT Gould Belt Survey: A First Look at Southen Orion A with SCUBA-2
title: The JCMT Gould Belt Survey: A First Look at Southen Orion A with SCUBA-2

description: This contains data and other information related to the publication 'The JCMT Gould Belt Survey: A First Look at Southen Orion A with SCUBA-2 by S. Mairs et al. MNRAS, 2016
DOI: 10.11570/16.0006
title: The JCMT Gould Belt Survey: Evidence for radiative heating and contamination in the W40 complex
title: The JCMT Gould Belt Survey: Evidence for radiative heating and contamination in the W40 complex

description: This contains data and other information related to the publication 'The JCMT Gould Belt Survey: Evidence for radiative heating and contamination in the W40 complex', by Rumble, D. et al.
DOI: 10.6084/m9.figshare.13570655
title: Early Islamic Qibla Database 2021

description: This is an Excel spreadsheet with 160 mosques and prayer <br>places listed in chronological order along with GPS coordinates and other information. These places date starting from the very first mosques built in Medina onwards. I have tried to produce an exhaustive list for the first two centuries of Islam, then major mosques for the third century, followed by a few important later mosques. I have been updating this list on a regular basis for the last twenty years, but now that it is published here, I will post a new list only after any major additions. <br>An active up-to-date list is published on my website: https://nabataea.net/ Follow the menu Founding of Islam <br>/Qibla Tool. This tool provides a graphical overview of this <br>spread-sheet. I have included one column in this spreadsheet with my own classifications.Dan Gibson January 2021<br>
DOI: 10.11570/17.0008
title: The JCMT Gould Belt Survey: A first look at the Auriga-California Molecular Cloud with SCUBA-2
title: The JCMT Gould Belt Survey: A first look at the Auriga-California Molecular Cloud with SCUBA-2

description: This contains data and other information related to the publication 'The JCMT Gould Belt Survey: A first look at the Auriga-California Molecular Cloud with SCUBA-2' by Broekhoven-Fiene, H. et al., ApJS, 2017
DOI: 10.11570/17.0009
title: The Dusty Galactic Centre as seen by SCUBA-2
title: The Dusty Galactic Centre as seen by SCUBA-2

description: This contains data and other information related to the publication 'The Dusty Galactic Centre as seen by SCUBA-2' by Parsons, H. et al., ApJS, 2017
DOI: 10.11570/17.0005
title: SONS: The JCMT legacy survey of debris discs in the submillimetre
title: SONS: The JCMT legacy survey of debris discs in the submillimetre

description: This contains data and other information related to the publication 'SONS: The JCMT legacy survey of debris discs in the submillimetre' by Holland, Wayne S. et al., 2017, MNRAS, 470, 3606
DOI: 10.11570/17.0006
title: Identifying Tools for Comparing Simulations and Observations of Spectral-line Data Cubes
title: Identifying Tools for Comparing Simulations and Observations of Spectral-line Data Cubes

description: This contains data and other information related to the publication 'Identifying Tools for Comparing Simulations and Observations of Spectral-line Data Cubes' by Eric, W. Koch, MNRAS, 2017
DOI: 10.11570/17.0004
title: The JCMT Plane Survey: First complete data release - emission maps and compact source catalogue
title: The JCMT Plane Survey: First complete data release - emission maps and compact source catalogue

description: This contains data and other information related to the publication 'The JCMT Plane Survey: First complete data release - emission maps and compact source catalogue ' by Eden, D.J. et al., Monthly Notices Royal Astronomical Society , 2017, DOI: 10.1093/mnras/stx874
DOI: 10.5066/f7qv3jn1
title: Southwestern Riparian Plant Trait Matrix, Colorado River, Grand Canyon, 2014 - 2016Data

description: This dataset contains information on the physical traits and environmental tolerances of plant species occurring along the lower Colorado River through Grand Canyon. Due to the unique combination of plant species within the Grand Canyon, this flora shares species with many riparian areas in the western U.S.A. and represents obligate wetland to obligate upland plant species. Data for the matrix were compiled from published scientific papers, unpublished reports, plant fact sheets, existing trait databases, regional floras, and plant guides. Categorical, ordinal, and continuous data are included in this dataset. This dataset does not contain sensitive or classified data.
DOI: 10.11570/17.0003
title: A 1420 MHz Catalog of Compact Sources in the Northern Galactic Plane
title: A 1420 MHz Catalog of Compact Sources in the Northern Galactic Plane

description: This contains data and other information related to the publication 'A 1420 MHz Catalog of Compact Sources in the Northern Galactic Plane' by Taylor, A.R. et al., Astronomical Journal, 2017
DOI: 10.11570/16.0009
title: THE STRUCTURE OF THE DISTANT KUIPER BELT IN A NICE MODEL SCENARIO
title: THE STRUCTURE OF THE DISTANT KUIPER BELT IN A NICE MODEL SCENARIO

description: This contains data and other information related to the publication 'THE STRUCTURE OF THE DISTANT KUIPER BELT IN A NICE MODEL SCENARIO, Astronomical Journal 2017' and 'Brasser, R., and Morbidelli, A. 2013, Icarus, 225, 40'
DOI: 10.11570/17.0002
title: The JCMT Gould Belt Survey: A First Look at SCUBA-2 Observations of the Lupus I Molecular Cloud
title: The JCMT Gould Belt Survey: A First Look at SCUBA-2 Observations of the Lupus I Molecular Cloud

description: This contains data and other information related to the publication 'The JCMT Gould Belt Survey: A First Look at SCUBA-2 Observations of the Lupus I Molecular Cloud ' by Mowat, C. et al., MNRAS, 2017
DOI: 10.11570/17.0001
title: The JCMT Gould Belt Survey: A First Look at IC5146
title: The JCMT Gould Belt Survey: A First Look at IC5146

description: This contains data and other information related to the publication 'The JCMT Gould Belt Survey: A First Look at IC5146, Johnstone, D. et al., Astrophysical Journal 2017
DOI: 10.11570/16.0002
title: The JCMT and Herschel Gould Belt Surveys: A comparison of SCUBA-2 and Herschel data of dense cores in the Taurus dark cloud L1495 AND The JCMT Gould Belt Survey: First results from SCUBA-2 observations of the Cepheus Flare Region
title: The JCMT and Herschel Gould Belt Surveys: A comparison of SCUBA-2 and Herschel data of dense cores in the Taurus dark cloud L1495 AND The JCMT Gould Belt Survey: First results from SCUBA-2 observations of the Cepheus Flare Region

description: This contains data and other information related to the publication 'The JCMT and Herschel Gould Belt Surveys: A comparison of SCUBA-2 and Herschel data of dense cores in the Taurus dark cloud L1495' MNRAS, 2016, 463, 1008, DOI: 10.1093/mnras/stw1978 AND 'The JCMT Gould Belt Survey: First results from SCUBA-2 observations of the Cepheus Flare Region', MNRAS, 2016, 464, 4255, DOI: 10.1093/mnras/stw2648
DOI: 10.5255/ukda-sn-855445
title: Associations between Childhood Maltreatment and Peer Relationships: the Role of Empathy, 2020-2021

description: In the literature, it has been well-established that children who have experienced maltreatment are at greater risk of impaired social development. Research also shows that, relative to non-maltreated peers, physically abused or neglected young children are more vulnerable to peer relation difficulties. This susceptibility is of concern, not only as there is preliminary evidence to suggest that positive peer relations can act as a potential protective factor, but also peer rejection is a known risk factor for poor adjustment in adolescence and adulthood. Taken together, peer relationships appear to be critical contexts for development and are likely important mediators or moderators of development and adjustment for children who have been maltreated. One psychological ability believed to be implicated in the developmental trajectory of maltreated children is empathy and it has been posited that it may act as a potential mediator between childhood maltreatment and problematic peer relations. To explore this association, this study used online adult-report questionnaires to collect data from parents of adopted children with a history of maltreatment and children living with their biological parents without such a history (6-11 years of age). Scales included a parent-report measure of child empathy and a parent-report measure on the quality of children’s peer relations. Further data was also collected from a sub-sample of children who completed additional behavioural measures of empathy and a peer relationships measure. Findings show that maltreated children scored significantly lower on parent-report measures of empathy and scored significantly higher on parent-report peer relationship problems than non-maltreated children. The behavioural data showed similar group level differences for child empathy, however, no differences were found for child-report peer relations. In terms of the proposed mediational model, empathy was found to mediate the relationship between maltreatment and poor peer relations. These findings are encouraging as they suggest that interventions that target empathy may help maltreated children to enjoy more positive and satisfying relationships with their peers.
DOI: 10.5286/isis.e.rb2010471-2
title: NR Study of the Membrane Intake Mechanism during the Plasmid Gene Delivery by a Microﬂuidic Synthetic Lipid Nanoparticle

description: With lipid nanoparticles (LNP) becoming an important vehicle for loading and delivering genes, it is ever crucial to understand how LNPs interact with cell membranes. Lack of understanding of the molecular processes across the membrane hinders our capability in controlling the delivery of genes into cells and associated cytotoxicity. To approach this challenging issue, we propose to produce a supported lipid bilayer (SLB) onto an optically flat silicon substrate from small uni-lamellar vesicles (SUVs) and follow their interactions with different LNPs with and without DNA. To enhance the resolution of NR, we could easily manipulate the H/D labelling to lipids inside the bilayer or in the LNPs and water. This is the time time such an experiment is going to be pursued from NR. From this work, we expect to gain first-hand information about the LNP-lipid bilayer interactive processes.
DOI: 10.6084/m9.figshare.16802158.v8
title: Good Fences Make Good Neighbours? On the Impact of Cultural and Geographical Dispersion on Community Smells

description: Appendix and Replication Package of the paper titled <b>Good Fences Make Good Neighbours! On the Impact of Cultural and Geographical Dispersion on Community Smells</b>.
DOI: 10.6084/m9.figshare.18866441
title: Student interest transgender gynecologic education

description: Data from manuscript entitled "Medical Student Interest in Expanded Transgender Gynecologic Education."
DOI: 10.6084/m9.figshare.18866441.v2
title: Student interest transgender gynecologic education

description: Data from manuscript entitled "Medical Student Interest in Expanded Transgender Gynecologic Education."
DOI: 10.6084/m9.figshare.18866441.v1
title: Transgender Course Data

description: Data from manuscript entitled "Medical Student Interest in Expanded Transgender Gynecologic Education."
DOI: 10.5967/j2aj-yr80
title: Convection-permitting downscaling of climate change 1950-2100

description: We provide a dynamically downscaled and bias corrected dataset at 3 km horizontal resolution over the U.S. Midwest, covering the period 1951-2100 under historical and RCP8.5 conditions. Data is produced using a regional model (WRF 3.9), driven by NCEP/NCAR reanalysis 1 and CESM1 simulations designed for downscaling with WRF. Data provided includes temperature (T2) and precipitation (PRECIP). This is associated with Lauer et al. (2022).
DOI: 10.5519/4q5uvvpa
title: Diversity and evolution of amphibian pupil shapes

description: Pupil constriction has important functional consequences for animal vision, yet the evolutionary mechanisms underlying diverse pupil sizes and shapes are poorly understood. We aimed to quantify the diversity and evolution of pupil shapes among amphibians and test for potential correlations to ecology based on functional hypotheses. Using photographs, we surveyed pupil shape across adults of 1293 amphibian species, 72 families, and 3 orders, and additionally for larval life stages for all families of frogs and salamanders with a biphasic ontogeny. For amphibians with a biphasic life history, we found that pupils change in many species that occupy distinct habitats before and after metamorphosis. In addition, we found that non-elongated (round or diamond) constricted pupils were correlated with species inhabiting consistently dim light environments (burrowing and aquatic species) and that elongated pupils (vertical and horizontal) were more common in species with larger absolute eye sizes. We propose that amphibians provide a valuable group within which to explore the anatomical, physiological, optical, and ecological mechanisms underlying the evolution of pupil shape.
DOI: 10.5517/ccdc.csd.cc207fk8
title: CCDC 1854189: Experimental Crystal Structure Determination

description: Related Article: Olga Botezat,  Jan van Leusen,  Paul Kögerler, Svetlana G. Baca|2019|Eur.J.Inorg.Chem.|2019|2236|doi:10.1002/ejic.201900175
DOI: 10.5517/ccdc.csd.cc207fl9
title: CCDC 1854190: Experimental Crystal Structure Determination

description: Related Article: Olga Botezat,  Jan van Leusen,  Paul Kögerler, Svetlana G. Baca|2019|Eur.J.Inorg.Chem.|2019|2236|doi:10.1002/ejic.201900175
DOI: 10.5517/ccdc.csd.cc207fnc
title: CCDC 1854192: Experimental Crystal Structure Determination

description: Related Article: Olga Botezat,  Jan van Leusen,  Paul Kögerler, Svetlana G. Baca|2019|Eur.J.Inorg.Chem.|2019|2236|doi:10.1002/ejic.201900175
DOI: 10.5517/ccdc.csd.cc207fpd
title: CCDC 1854193: Experimental Crystal Structure Determination

description: Related Article: Olga Botezat,  Jan van Leusen,  Paul Kögerler, Svetlana G. Baca|2019|Eur.J.Inorg.Chem.|2019|2236|doi:10.1002/ejic.201900175
DOI: 10.5517/ccdc.csd.cc207fqf
title: CCDC 1854194: Experimental Crystal Structure Determination

description: Related Article: Olga Botezat,  Jan van Leusen,  Paul Kögerler, Svetlana G. Baca|2019|Eur.J.Inorg.Chem.|2019|2236|doi:10.1002/ejic.201900175
DOI: 10.5517/ccdc.csd.cc207frg
title: CCDC 1854195: Experimental Crystal Structure Determination

description: Related Article: Olga Botezat,  Jan van Leusen,  Paul Kögerler, Svetlana G. Baca|2019|Eur.J.Inorg.Chem.|2019|2236|doi:10.1002/ejic.201900175
DOI: 10.5517/ccdc.csd.cc207ftj
title: CCDC 1854197: Experimental Crystal Structure Determination

description: Related Article: Olga Botezat,  Jan van Leusen,  Paul Kögerler, Svetlana G. Baca|2019|Eur.J.Inorg.Chem.|2019|2236|doi:10.1002/ejic.201900175
DOI: 10.5517/ccdc.csd.cc207fvk
title: CCDC 1854198: Experimental Crystal Structure Determination

description: Related Article: Olga Botezat,  Jan van Leusen,  Paul Kögerler, Svetlana G. Baca|2019|Eur.J.Inorg.Chem.|2019|2236|doi:10.1002/ejic.201900175
DOI: 10.5517/ccdc.csd.cc207fwl
title: CCDC 1854199: Experimental Crystal Structure Determination

description: Related Article: Olga Botezat,  Jan van Leusen,  Paul Kögerler, Svetlana G. Baca|2019|Eur.J.Inorg.Chem.|2019|2236|doi:10.1002/ejic.201900175
DOI: 10.5517/ccdc.csd.cc207fzp
title: CCDC 1854202: Experimental Crystal Structure Determination

description: Related Article: Olga Botezat,  Jan van Leusen,  Paul Kögerler, Svetlana G. Baca|2019|Eur.J.Inorg.Chem.|2019|2236|doi:10.1002/ejic.201900175
DOI: 10.5517/ccdc.csd.cc1yt6gf
title: CCDC 1811685: Experimental Crystal Structure Determination

description: Related Article: Nan Li, Bing-Tao Guan|2019|Eur.J.Inorg.Chem.|2019|2231|doi:10.1002/ejic.201900168
DOI: 10.5517/ccdc.csd.cc20z8w5
title: CCDC 1876147: Experimental Crystal Structure Determination

description: Related Article: Pooja Shukla,  Ramesh K Metre,  Ming-Hao Du,  Xiang-Jian Kong, Sourav Das|2019|Eur.J.Inorg.Chem.|2019|2216|doi:10.1002/ejic.201900163
DOI: 10.5517/ccdc.csd.cc20z8x6
title: CCDC 1876148: Experimental Crystal Structure Determination

description: Related Article: Pooja Shukla,  Ramesh K Metre,  Ming-Hao Du,  Xiang-Jian Kong, Sourav Das|2019|Eur.J.Inorg.Chem.|2019|2216|doi:10.1002/ejic.201900163
DOI: 10.5517/ccdc.csd.cc273lgf
title: CCDC 2059034: Experimental Crystal Structure Determination

description: Related Article: Johannes Moll, Christoph Förster, Alexandra König, Luca M. Carrella, Manfred Wagner, Martin Panthöfer, Angela Möller, Eva Rentschler, Katja Heinze|2022|Inorg.Chem.|61|1659|doi:10.1021/acs.inorgchem.1c03511
DOI: 10.5517/ccdc.csd.cc277htt
title: CCDC 2062796: Experimental Crystal Structure Determination

description: Related Article: Johannes Moll, Christoph Förster, Alexandra König, Luca M. Carrella, Manfred Wagner, Martin Panthöfer, Angela Möller, Eva Rentschler, Katja Heinze|2022|Inorg.Chem.|61|1659|doi:10.1021/acs.inorgchem.1c03511
DOI: 10.5517/ccdc.csd.cc277hvv
title: CCDC 2062797: Experimental Crystal Structure Determination

description: Related Article: Johannes Moll, Christoph Förster, Alexandra König, Luca M. Carrella, Manfred Wagner, Martin Panthöfer, Angela Möller, Eva Rentschler, Katja Heinze|2022|Inorg.Chem.|61|1659|doi:10.1021/acs.inorgchem.1c03511
DOI: 10.34740/kaggle/dsv/3107003
title: Vietnam SARS-CoV-2 | COVID-19 Data
DOI: 10.25346/s6/b5golx/tdyf71
title: Final Policy Project Index.csv
DOI: 10.25346/s6/b5golx/xw7pct
title: policy-index-faqs.pdf

description: About the Policy Project's process
DOI: 10.25346/s6/b5golx/md99nl
title: Final Policy Project Index.tab

description: Microsoft Excel File
DOI: 10.25346/s6/b5golx/xcvely
title: policy-index-term-definitions.pdf

description: Category definitions
DOI: 10.25494/p6dg6d
title: Coastal pelagic species--seine/net commercial fishery, Moss Landing, Post MPA

description: This data set is a part of Ecotrust's project entitled: Establishing a Baseline and Assessing Spatial and Socioeconomic Change in the California Central Coast Commercial and CPFV Fisheries. This project is a component of the California Central Coast Marine Protected Area Baseline Monitoring Project that is designed to characterize the ecological and socioeconomic conditions and changes within the Central Coast Region since MPA implementation. The Central Coast study region extends from the north at Pigeon Point to the south at Point Conception. This data set consists of data collected in the spring of 2012 from fisheries mapping interviews with commercial fishermen who had Coastal pelagic species--seine/net landings in the port of Moss Landing in 2011. Results from the interviews were then combined through an aggregation process where the value each fisherman gives to their Coastal pelagic species fishing grounds are weighted by their landings for Coastal pelagic species in 2011. This data set represents the spatial extent and relative value of Coastal pelagic species commercial fishing grounds for the port of Moss Landing in the year 2011.