cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.7139042.v1
title: Additional file 3: of Epigenetic prediction of complex traits and death

description: Table S11. Prediction of traits with and without genetic scores. Table S12. Cox proportional hazards survival models output for phenotypic, epigenetic (DNAm), and genetic (polygenic) predictors of health and lifestyle factors. (XLSX 14 kb)
DOI: 10.6084/m9.figshare.19722013
title: Accelerating OCR-Based Widget Localization for Test Automation of GUI Applications

description: The source code and the datasets used in the experiment.
DOI: 10.6084/m9.figshare.14479145
title: Geographical distribution and migration routes of the medical bryophyte, <i>Climacium dendroides</i>, under climate warming in China

description: <i>Climacium dendroides</i> is a rare bryophyte resource with important medicinal value, which is mainly concentrated in the southwest and northeast China. In recent years, we found in the wild investigation that the population of <i>C. dendroides</i> had shrunk. In our study, based on high-resolution environmental variables and geographical occurrence records, the Maximum Entropy Model (MaxEnt) combined with ArcGIS was used to predict the spatial-temporal distributional pattern of <i>C. dendroides</i> in China under the current and future scenarios. Simulation results revealed that the total suitable area decreases by more than a third (–36.02%) in future scenarios. Further, the distributional centers moved to the northwest. Annual precipitation, max temperature of warmest month, and annual mean air temperature were the key environmental factors affecting the distribution of <i>C. dendroides</i>. Global warming coupled with the adverse effects of anthropogenic activities might accelerate the disappearance of suitable habitats for <i>C. dendroides</i>. Overall, our research provides useful indications for protecting the diversity of medical bryophytes and for their conservation. Supplemental data for this article is available online at http://dx.doi.org/10.1080/11263504.2021.1906348
DOI: 10.6084/m9.figshare.14479145.v1
title: Geographical distribution and migration routes of the medical bryophyte, <i>Climacium dendroides</i>, under climate warming in China

description: <i>Climacium dendroides</i> is a rare bryophyte resource with important medicinal value, which is mainly concentrated in the southwest and northeast China. In recent years, we found in the wild investigation that the population of <i>C. dendroides</i> had shrunk. In our study, based on high-resolution environmental variables and geographical occurrence records, the Maximum Entropy Model (MaxEnt) combined with ArcGIS was used to predict the spatial-temporal distributional pattern of <i>C. dendroides</i> in China under the current and future scenarios. Simulation results revealed that the total suitable area decreases by more than a third (–36.02%) in future scenarios. Further, the distributional centers moved to the northwest. Annual precipitation, max temperature of warmest month, and annual mean air temperature were the key environmental factors affecting the distribution of <i>C. dendroides</i>. Global warming coupled with the adverse effects of anthropogenic activities might accelerate the disappearance of suitable habitats for <i>C. dendroides</i>. Overall, our research provides useful indications for protecting the diversity of medical bryophytes and for their conservation. Supplemental data for this article is available online at http://dx.doi.org/10.1080/11263504.2021.1906348
DOI: 10.6084/m9.figshare.17624888
title: Social Drosophila Pose Dataset (SDPD-15k)

description: Social Drosophila Pose Dataset (SDPD-15k)
DOI: 10.6084/m9.figshare.24440687
title: Comparative efficacy and safety of different doses of ponatinib versus other tyrosine kinase inhibitors for the treatment of chronic myeloid leukemia: a systematic review and network meta-analysis

description: Ponatinib was recommended with caution because of its high risk of causing arterial occlusion events in chronic myeloid leukemia (CML) patients. The purpose of this study was to understand the efficacy and safety of different doses of ponatinib in the treatment of CML, and to compare it with other tyrosine kinase inhibitors (TKIs). A network meta-analysis (NMA) was conducted by searching randomized controlled trials (RCTs) of ponatinib in patients with CML to compare the efficacy and safety of ponatinib, and ranked under the cumulative ranking curve (SUCRA) to evaluate the optimal treatment. A total of seven articles with eight RCTs were included in this study, involving 45 mg, 30 mg and 15 mg ponatinib doses. Seven outcome indexes were analyzed. The results showed that 45 mg ponatinib was superior to other doses of ponatinib and other TKIs in CCyR, MCyR and CHR, but the incidence of SAEs and AOEs was significantly higher than other treatment regimens. Ponatinib, with an initial dosage of 45 mg and a gradual reduction to 15 mg, may be a more favorable option for patients with CML at all stages of disease progression, rather than just those in the chronic phase of CML.
DOI: 10.6084/m9.figshare.24440687.v1
title: Comparative efficacy and safety of different doses of ponatinib versus other tyrosine kinase inhibitors for the treatment of chronic myeloid leukemia: a systematic review and network meta-analysis

description: Ponatinib was recommended with caution because of its high risk of causing arterial occlusion events in chronic myeloid leukemia (CML) patients. The purpose of this study was to understand the efficacy and safety of different doses of ponatinib in the treatment of CML, and to compare it with other tyrosine kinase inhibitors (TKIs). A network meta-analysis (NMA) was conducted by searching randomized controlled trials (RCTs) of ponatinib in patients with CML to compare the efficacy and safety of ponatinib, and ranked under the cumulative ranking curve (SUCRA) to evaluate the optimal treatment. A total of seven articles with eight RCTs were included in this study, involving 45 mg, 30 mg and 15 mg ponatinib doses. Seven outcome indexes were analyzed. The results showed that 45 mg ponatinib was superior to other doses of ponatinib and other TKIs in CCyR, MCyR and CHR, but the incidence of SAEs and AOEs was significantly higher than other treatment regimens. Ponatinib, with an initial dosage of 45 mg and a gradual reduction to 15 mg, may be a more favorable option for patients with CML at all stages of disease progression, rather than just those in the chronic phase of CML.
DOI: 10.6084/m9.figshare.24440692
title: Supplementary Data for Zhang et al. "Public Discourses and Government Interventions behind China’s Ambitious Carbon Neutrality Goal"

description: Supplementary data for the article "Public Discourses and Government Interventions behind China’s Ambitious Carbon Neutrality Goal". This dataset contains the following six files:Overall Weibo Data: Source data for Figure 1, Figure 2, Supplementary Figure 1, Supplementary Figure 2.Influencer Weibo Data: Source data for Figure 3.Government Weibo Data: Source data for Figure 4.Policy Weibo Data: Source data for Figure5, Supplementary Figure 3, Supplementary Figure 4, Supplementary Figure 5.General User Demography Data, Influencer Demography Data: Source data for Supplementary Figure 6.
DOI: 10.6084/m9.figshare.9760658
title: Additional file 10: of Downregulation of exosomal CLEC3B in hepatocellular carcinoma promotes metastasis and angiogenesis via AMPK and VEGF signals

description: Table S3. Genes correlated to CLEC3B in TCGA database. (XLSX 1010 kb)
DOI: 10.6084/m9.figshare.9760658.v1
title: Additional file 10: of Downregulation of exosomal CLEC3B in hepatocellular carcinoma promotes metastasis and angiogenesis via AMPK and VEGF signals

description: Table S3. Genes correlated to CLEC3B in TCGA database. (XLSX 1010 kb)
DOI: 10.6084/m9.figshare.9760679
title: Additional file 13: of Downregulation of exosomal CLEC3B in hepatocellular carcinoma promotes metastasis and angiogenesis via AMPK and VEGF signals

description: Table S4. The functional enrichment of KEGG pathway. (XLSX 27 kb)
DOI: 10.6084/m9.figshare.9760679.v1
title: Additional file 13: of Downregulation of exosomal CLEC3B in hepatocellular carcinoma promotes metastasis and angiogenesis via AMPK and VEGF signals

description: Table S4. The functional enrichment of KEGG pathway. (XLSX 27 kb)
DOI: 10.5281/zenodo.10677315
title: Mushroom Farming: Exploring Varieties, Cultivation Strategies, and Endless Possibilities
DOI: 10.5281/zenodo.10677316
title: Mushroom Farming: Exploring Varieties, Cultivation Strategies, and Endless Possibilities
DOI: 10.5281/zenodo.10677330
title: Exploring hydrocarbon degrading ability of bacteria isolated from engine oil polluted soil.
DOI: 10.5281/zenodo.10677331
title: Exploring hydrocarbon degrading ability of bacteria isolated from engine oil polluted soil.
DOI: 10.5281/zenodo.10677338
title: Impact of Commercial Detergents on Organogenesis in Allium Cepa L and Utility of Foldscpe Tool
DOI: 10.5281/zenodo.10677339
title: Impact of Commercial Detergents on Organogenesis in Allium Cepa L and Utility of Foldscpe Tool
DOI: 10.6084/m9.figshare.9760775
title: Additional file 1: of The SNPs in myoD gene from normal muscle developing individuals have no effect on muscle mass

description: Table S1. The information of all samples. (XLSX 295 kb)
DOI: 10.6084/m9.figshare.9760775.v1
title: Additional file 1: of The SNPs in myoD gene from normal muscle developing individuals have no effect on muscle mass

description: Table S1. The information of all samples. (XLSX 295 kb)
DOI: 10.6084/m9.figshare.8187947
title: Detecting of chloroplast circular RNAs in <i>Arabidopsis thaliana</i>

description: Circular RNAs (circRNAs) are covalently closed single-strand RNA molecules identified in eukaryotes. Here we report 10 sequences of chloroplast genome (cpDNA) encoded circRNAs (cp-circRNA) from 3-day-old <i>Arabidopsis thaliana</i> seedlings via next-generation sequencing. Their parental sequences were referred to as exonic, intronic, and intergenic gene sequences. Due to the very low level of cp-circRNA expression, we attempted to use a digital polymerase chain reaction technique to validate their existence. Four of these circRNAs were confirmed: <i>ath_circ_476, ath_circ_477, ath_circ_478</i>, and <i>ath_circ_480</i>. Their expression levels in etiolated and de-etiolated seedlings were quantified using digital PCR. Of the four, the exonic circRNA <i>ath_circ_476</i> was highly expressed in etiolated seedlings. Its parental gene, <i>cytochrome C assembly protein</i> (<i>ycf5</i>), has expression trends similar to <i>ath_circ_476</i>. Given that <i>ycf5</i> is a single-exon gene, we propose that the circularization of <i>ath_circ_476</i> occurs via an unknown process rather than via RNA-splicing-based mechanisms. Therefore, we provided a reliable method for detecting cp-circRNAs in low copies and implied an unknown circularisation mechanism of RNA in chloroplasts.
DOI: 10.6084/m9.figshare.8187947.v1
title: Detecting of chloroplast circular RNAs in <i>Arabidopsis thaliana</i>

description: Circular RNAs (circRNAs) are covalently closed single-strand RNA molecules identified in eukaryotes. Here we report 10 sequences of chloroplast genome (cpDNA) encoded circRNAs (cp-circRNA) from 3-day-old <i>Arabidopsis thaliana</i> seedlings via next-generation sequencing. Their parental sequences were referred to as exonic, intronic, and intergenic gene sequences. Due to the very low level of cp-circRNA expression, we attempted to use a digital polymerase chain reaction technique to validate their existence. Four of these circRNAs were confirmed: <i>ath_circ_476, ath_circ_477, ath_circ_478</i>, and <i>ath_circ_480</i>. Their expression levels in etiolated and de-etiolated seedlings were quantified using digital PCR. Of the four, the exonic circRNA <i>ath_circ_476</i> was highly expressed in etiolated seedlings. Its parental gene, <i>cytochrome C assembly protein</i> (<i>ycf5</i>), has expression trends similar to <i>ath_circ_476</i>. Given that <i>ycf5</i> is a single-exon gene, we propose that the circularization of <i>ath_circ_476</i> occurs via an unknown process rather than via RNA-splicing-based mechanisms. Therefore, we provided a reliable method for detecting cp-circRNAs in low copies and implied an unknown circularisation mechanism of RNA in chloroplasts.
DOI: 10.6084/m9.figshare.19722284
title: The macrophage-associated microRNA-4715-3p / Gasdermin D axis potentially indicates fibrosis progression in nonalcoholic fatty liver disease: evidence from transcriptome and biological data

description: Nonalcoholic fatty liver disease (NAFLD) is highly possible to progress to cirrhosis, malignancy, and liver failure through fibrogenesis. The enormous potential of pathogenetic and therapeutic targets in NAFLD has been revealed. This study aimed to explore novel factors potentially indicating or mediating NAFLD progression. Multiple bulk and single-cell RNA sequencing datasets were used, in which landscapes of cell populations were clarified to characterize immune cell infiltration. Significantly high infiltration of macrophages (MPs) was discovered during NAFLD progression. Samples in bulk NASH datasets were regrouped by MP level. Highly differentially expressed genes (DEGs) were identified in the Ctrl vs. NASH comparison, low MP vs. high MP comparison, and the weighted gene co-expression network analysis (WGCNA) clusters. Eight hub genes were identified as promising targets by protein–protein interaction analysis and validated in fibrosis progression, microRNA (miR)–protein interactions were predicted, and the hub genes were verified in a free fatty acid (FFA)-induced macrophage injury model. The results showed that Gasdermin D (<i>GSDMD</i>) was upregulated with fibrosis progression in NAFLD and was associated with macrophage infiltration. In addition, a potential regulator (miR-4715-3p) was correlated with <i>GSDMD</i>. The miR-4715-3p/<i>GSDMD</i> axis potentially modulates macrophage-associated immunity and indicates fibrosis progression in NAFLD.
DOI: 10.6084/m9.figshare.19722284.v1
title: The macrophage-associated microRNA-4715-3p / Gasdermin D axis potentially indicates fibrosis progression in nonalcoholic fatty liver disease: evidence from transcriptome and biological data

description: Nonalcoholic fatty liver disease (NAFLD) is highly possible to progress to cirrhosis, malignancy, and liver failure through fibrogenesis. The enormous potential of pathogenetic and therapeutic targets in NAFLD has been revealed. This study aimed to explore novel factors potentially indicating or mediating NAFLD progression. Multiple bulk and single-cell RNA sequencing datasets were used, in which landscapes of cell populations were clarified to characterize immune cell infiltration. Significantly high infiltration of macrophages (MPs) was discovered during NAFLD progression. Samples in bulk NASH datasets were regrouped by MP level. Highly differentially expressed genes (DEGs) were identified in the Ctrl vs. NASH comparison, low MP vs. high MP comparison, and the weighted gene co-expression network analysis (WGCNA) clusters. Eight hub genes were identified as promising targets by protein–protein interaction analysis and validated in fibrosis progression, microRNA (miR)–protein interactions were predicted, and the hub genes were verified in a free fatty acid (FFA)-induced macrophage injury model. The results showed that Gasdermin D (<i>GSDMD</i>) was upregulated with fibrosis progression in NAFLD and was associated with macrophage infiltration. In addition, a potential regulator (miR-4715-3p) was correlated with <i>GSDMD</i>. The miR-4715-3p/<i>GSDMD</i> axis potentially modulates macrophage-associated immunity and indicates fibrosis progression in NAFLD.
DOI: 10.6084/m9.figshare.9760814
title: Additional file 7: of Preoperative hypoalbuminemia was associated with acute kidney injury in high-risk patients following non-cardiac surgery: a retrospective cohort study

description: Dataset. Relevant data underlying the main results. (XLSX 413 kb)
DOI: 10.6084/m9.figshare.9760814.v1
title: Additional file 7: of Preoperative hypoalbuminemia was associated with acute kidney injury in high-risk patients following non-cardiac surgery: a retrospective cohort study

description: Dataset. Relevant data underlying the main results. (XLSX 413 kb)
DOI: 10.5281/zenodo.10677341
title: Nano-pesticide for Agriculture: Applications& Benefits
DOI: 10.5281/zenodo.10677342
title: Nano-pesticide for Agriculture: Applications& Benefits
DOI: 10.6084/m9.figshare.23916612
title: <b>Roux-en-Y gastric bypass improves insulin sensitivity in obese rats with type 2 diabetes mellitus by regulating the Grin3a /AMPK signal axis in </b><b>hypothalamic arcuate nucleus</b>

description: RYGB reduced FBG, FSI, HOMA-IR and plasma TG levels in T2DM rats while increased Grin3a expression and p-AMPK/AMPK ratio in ARC. Knockdown of Grin3a not only reversed the decreasing effects of RYGB on FBG, FSI, HOMA-IR and plasma TG levels in T2DM rats and but also reversed the up-regulation of RYGB on p-AMPK/AMPK ratio in ARC. Moreover, knocking down Grin3a could significantly increase the level of TG, promote the formation of lipid droplets and up-regulate the expressions of PPARγ, C/ebpα, FASN and FABP4 in differentiated 3T3-L1 cells.RYGB improves the insulin sensitivity, reduces the plasma TG level and lessens the fat accumulation in obese rats with T2DM by regulating the Grin3a /AMPK signal axis in hypothalamic ARC.
DOI: 10.6084/m9.figshare.9760838
title: Additional file 2: of A descriptive analysis of the Spatio-temporal distribution of intestinal infectious diseases in China

description: The number of cases of IIDs. (XLS 68 kb)
DOI: 10.6084/m9.figshare.9760838.v1
title: Additional file 2: of A descriptive analysis of the Spatio-temporal distribution of intestinal infectious diseases in China

description: The number of cases of IIDs. (XLS 68 kb)
DOI: 10.25345/c5jd4q108
title: MassIVE MSV000094115 - GNPS-alkyne probe of CA for the identification of new secondary bile acids
title: Alkyne probe of CA (alkCA) was synthesized and incubated in human stool-derived ex vivo communities. The alkCA is transformed into CA-linker (CA-LNK) after the click reaction, and then analyzed by LC-MS/MS
DOI: 10.6084/m9.figshare.9760850
title: Additional file 3: of A descriptive analysis of the Spatio-temporal distribution of intestinal infectious diseases in China

description: The number of cases of IIDs by month; The Morbidity of IIDs by month. (XLSX 26 kb)
DOI: 10.6084/m9.figshare.9760850.v1
title: Additional file 3: of A descriptive analysis of the Spatio-temporal distribution of intestinal infectious diseases in China

description: The number of cases of IIDs by month; The Morbidity of IIDs by month. (XLSX 26 kb)
DOI: 10.6084/m9.figshare.9760865
title: Additional file 5: of A descriptive analysis of the Spatio-temporal distribution of intestinal infectious diseases in China

description: The analysis process of reliability. (XLSX 45 kb)
DOI: 10.6084/m9.figshare.9760865.v1
title: Additional file 5: of A descriptive analysis of the Spatio-temporal distribution of intestinal infectious diseases in China

description: The analysis process of reliability. (XLSX 45 kb)
DOI: 10.6084/m9.figshare.19722341
title: LncRNA HOXA10-AS functions as an oncogene by binding miR-6509-5p to upregulate Y-box binding protein 1 in gastric cancer

description: Gastric cancer (GC) is one of the serious malignant diseases, accounting for several cases globally. The prevention, discovery and cure of GC depend on its molecular mechanism. In recent decades, it has been increasingly recognized that the long noncoding RNAs (lncRNAs) have been involved in GC progression. Therefore, the present study is aimed at identifying relevant lncRNAs that could act as biomarkers for GC prognosis. LncRNA HOXA10-AS is identified to be highly expressed in GC using the ENCORI database. Kaplan-Meier plot analysis indicated that the survival rate of the patient is associated with the expression of lncRNA HOXA10-AS. Interference of HOXA10-AS inhibited GC cell proliferation, migration, and invasion as well as facilitated GC apoptosis. The targets of HOXA10-AS included miR-6509-5p and Y-box binding protein 1 (YBX1). Specifically, HOXA10-AS downregulated miR-6509-5p in GC. An increase of miR-6509-5p inhibited GC cell growth. Meanwhile, miR-6509-5p interacted with YBX1 in GC. Together, lncRNA HOXA10-AS potentially acted as an oncogene through the lncRNA HOXA10-AS/miR-6509-5p/YBX1 signaling pathway in GC.
DOI: 10.6084/m9.figshare.19722341.v1
title: LncRNA HOXA10-AS functions as an oncogene by binding miR-6509-5p to upregulate Y-box binding protein 1 in gastric cancer

description: Gastric cancer (GC) is one of the serious malignant diseases, accounting for several cases globally. The prevention, discovery and cure of GC depend on its molecular mechanism. In recent decades, it has been increasingly recognized that the long noncoding RNAs (lncRNAs) have been involved in GC progression. Therefore, the present study is aimed at identifying relevant lncRNAs that could act as biomarkers for GC prognosis. LncRNA HOXA10-AS is identified to be highly expressed in GC using the ENCORI database. Kaplan-Meier plot analysis indicated that the survival rate of the patient is associated with the expression of lncRNA HOXA10-AS. Interference of HOXA10-AS inhibited GC cell proliferation, migration, and invasion as well as facilitated GC apoptosis. The targets of HOXA10-AS included miR-6509-5p and Y-box binding protein 1 (YBX1). Specifically, HOXA10-AS downregulated miR-6509-5p in GC. An increase of miR-6509-5p inhibited GC cell growth. Meanwhile, miR-6509-5p interacted with YBX1 in GC. Together, lncRNA HOXA10-AS potentially acted as an oncogene through the lncRNA HOXA10-AS/miR-6509-5p/YBX1 signaling pathway in GC.
DOI: 10.6084/m9.figshare.19722347
title: Establishment and validation of nomogram model for survival predicting in patients with spinal metastases secondary to lung cancer

description: To evaluate the prognostic effect of pre-treatment factors in patients with spinal metastases secondary to lung cancer, and establish a novel predicting nomogram for predicting the survival probability. A total of 209 patients operated for spinal metastases from lung cancer were consecutively enrolled, and divided into the training and validation samples with a ratio of 7:3, for model establishing and validating, respectively. Basing on the training sample, univariate and multivariate COX proportional hazard models were used for identifying the prognostic effect of pre-treatment factors, following which significant prognostic factors would be listed as items in nomogram to calculate the survival probabilities at 3, 6, 12 and 18 months. Then, the C-indexes and the calibration curves would be figured out to evaluate the discrimination ability and accuracy of the model both for the training and validation samples. In the multivariate COX analysis, the gender, smoking history, location of spinal metastasis, visceral metastasis, Karnofsky performance status (KPS), adjuvant therapy, lymphocyte percentage and globulin were found to be significantly associated with the overall survival, and a novel nomogram was generated basing on these independent predictors. The C-indexes for the training and validation samples were 0.761 and 0.732, respectively. Favorable consistencies between the predicted and actual survival rates were demonstrated both in the internal and external validations. Pre-treatment characteristics, including gender, smoking history, location of spinal metastasis, visceral metastasis, KPS, adjuvant therapy, percentage of lymphocyte, and serum globulin level, were identified to be significantly associated with overall survival of patients living with spinal metastases derived from lung cancer, and a user-friendly nomogram was established using these independent predictors.