cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.5718730.v1
title: Therapeutic effect and potential mechanism of pioglitazone in rats with severe acute pancreatitis

description: Caspase recruitment domain-containing protein 9 (Card9) is located upstream of the nuclear factor kappa B (NF-κB) and p38 mitogen-activated protein kinase (MAPK) inflammatory pathways. This study investigated the therapeutic effect and potential mechanism of pioglitazone in rats with severe acute pancreatitis (SAP). SAP was induced by a retrograde infusion of 5.0% sodium taurocholate into the biliopancreatic duct of Sprague Dawley rats (n=54), which were then treated with pioglitazone. Blood and pancreatic tissues were harvested at 3, 6, and 12 h after SAP induction. Pancreatic pathological damage was evaluated by hematoxylin and eosin staining. Serum amylase, serum pro-inflammatory cytokines, and pancreatic myeloperoxidase (MPO) activities were determined by enzyme-linked immunosorbent assay. The expression of Card9 mRNA and protein in pancreatic tissues was detected by real-time polymerase chain reaction and western blotting. Pioglitazone had a therapeutic effect in treating rats with SAP by decreasing the level of amylase activity, ameliorating pancreatic histological damage, decreasing serum pro-inflammatory cytokine levels and tissue MPO activity, and downregulating the expression of NF-κB, p38MAPK, and Card9 mRNAs and proteins (P&lt;0.05). The present study demonstrated that the inhibition of Card9 expression could reduce the severity of SAP. Card9 has a role in the pathogenic mechanism of SAP.
DOI: 10.6084/m9.figshare.5718718
title: Educational status influences cognitive-motor learning in older adults: going to university provides greater protection against aging than going to high school

description: ABSTRACT Objective: To investigate if middle-aged and older adults with a higher education would differ from those with an average education in cognitive-motor tasks involving lower limb function. Methods: A walking version of the Trail Making Test (Walking Executive Function Task, [WEFT]) was used. Eighty volunteers (40: 50–65 years; 40: 66–80 years) were subdivided into average (6–11years of education) and higher education (12–17 years). They received two training sessions (session 1: eight repetitions, session 2: four repetitions), with a one week-interval between them. The Timed Up and Go (TUG) test was performed before and after the training. Results: Volunteers with an average education showed longer times on the WEFT than those with a higher education. Older adults showed lower retention than middle-aged adults (p &lt; 0.001). The TUG was faster after the WEFT training (p &lt; 0.001). Conclusion: The impact of education was observed when locomotion was associated with cognitive tasks. Average education resulted in poorer performance and learning than higher education, mainly in older adults. Gait speed increased after training.
DOI: 10.6084/m9.figshare.5718718.v1
title: Educational status influences cognitive-motor learning in older adults: going to university provides greater protection against aging than going to high school

description: ABSTRACT Objective: To investigate if middle-aged and older adults with a higher education would differ from those with an average education in cognitive-motor tasks involving lower limb function. Methods: A walking version of the Trail Making Test (Walking Executive Function Task, [WEFT]) was used. Eighty volunteers (40: 50–65 years; 40: 66–80 years) were subdivided into average (6–11years of education) and higher education (12–17 years). They received two training sessions (session 1: eight repetitions, session 2: four repetitions), with a one week-interval between them. The Timed Up and Go (TUG) test was performed before and after the training. Results: Volunteers with an average education showed longer times on the WEFT than those with a higher education. Older adults showed lower retention than middle-aged adults (p &lt; 0.001). The TUG was faster after the WEFT training (p &lt; 0.001). Conclusion: The impact of education was observed when locomotion was associated with cognitive tasks. Average education resulted in poorer performance and learning than higher education, mainly in older adults. Gait speed increased after training.
DOI: 10.6084/m9.figshare.5718709
title: Induction of Labor using Misoprostol in a Tertiary Hospital in the Southeast of Brazil

description: Abstract Purpose To assess cases of labor induction with vaginal 25-μg tablets of misoprostol and maternal outcomes in a tertiary hospital in southeastern Brazil. Methods This was a retrospective cohort study of 412 pregnant women with indication for labor induction. Labor induction was performed with vaginal 25-μg tablets ofmisoprostol in pregnant women with Bishop scores &lt; 6. Stepwise regression analysis was used to identify the factors present at the beginning of induction that could be used as predictors of successful labor induction. Results A total of 69% of the pregnant women who underwent labor induction progressed to vaginal delivery, and 31% of the women progressed to cesarean section. One or two misoprostol tablets were used in 244 patients (59.2%). Of the 412 patients, 197 (47.8%) required oxytocin later on in the labor process, after induction with misoprostol. The stepwise regression analysis showed that only Bishop scores of 4 and 5 and previous vaginal delivery were independent factors with statistical significance in the prediction of successful vaginal labor induction (β = 0.23, p &lt; 0.001, for a Bishop score of 4 and 5, and β = 0.22, p &lt; 0.001, for previous vaginal delivery). Conclusion Higher Bishop scores and previous vaginal delivery were the best predictors of successful labor induction with vaginal 25-μg tablets of misoprostol.
DOI: 10.6084/m9.figshare.5718709.v1
title: Induction of Labor using Misoprostol in a Tertiary Hospital in the Southeast of Brazil

description: Abstract Purpose To assess cases of labor induction with vaginal 25-μg tablets of misoprostol and maternal outcomes in a tertiary hospital in southeastern Brazil. Methods This was a retrospective cohort study of 412 pregnant women with indication for labor induction. Labor induction was performed with vaginal 25-μg tablets ofmisoprostol in pregnant women with Bishop scores &lt; 6. Stepwise regression analysis was used to identify the factors present at the beginning of induction that could be used as predictors of successful labor induction. Results A total of 69% of the pregnant women who underwent labor induction progressed to vaginal delivery, and 31% of the women progressed to cesarean section. One or two misoprostol tablets were used in 244 patients (59.2%). Of the 412 patients, 197 (47.8%) required oxytocin later on in the labor process, after induction with misoprostol. The stepwise regression analysis showed that only Bishop scores of 4 and 5 and previous vaginal delivery were independent factors with statistical significance in the prediction of successful vaginal labor induction (β = 0.23, p &lt; 0.001, for a Bishop score of 4 and 5, and β = 0.22, p &lt; 0.001, for previous vaginal delivery). Conclusion Higher Bishop scores and previous vaginal delivery were the best predictors of successful labor induction with vaginal 25-μg tablets of misoprostol.
DOI: 10.6084/m9.figshare.5718706
title: Green Information Technology: A study in light of Belief-Action-Outcome theory

description: ABSTRACT This study aims to understand how institutional pressures and managers’ environmental beliefs influence the adoption of Green Information Technology (Green IT). The theoretical framework of the Belief-Action-Outcome model is used. In a qualitative research approach, data on 10 university IT managers were collected through interviews and a checklist of Green IT practices. Content analysis on the interviews was performed and the responses to the checklist were analyzed by frequency. Analysis results show that the institutional pressure most related to the adoption of Green IT for the interviewees is mimetic. Regarding environmental beliefs, while eight managers expressed concerns about environmental issues, only three reported their own initiatives. Other respondents said they faced barriers such as bureaucratic dysfunctions and lack of management support to propose actions related to Green IT.
DOI: 10.6084/m9.figshare.5718706.v1
title: Green Information Technology: A study in light of Belief-Action-Outcome theory

description: ABSTRACT This study aims to understand how institutional pressures and managers’ environmental beliefs influence the adoption of Green Information Technology (Green IT). The theoretical framework of the Belief-Action-Outcome model is used. In a qualitative research approach, data on 10 university IT managers were collected through interviews and a checklist of Green IT practices. Content analysis on the interviews was performed and the responses to the checklist were analyzed by frequency. Analysis results show that the institutional pressure most related to the adoption of Green IT for the interviewees is mimetic. Regarding environmental beliefs, while eight managers expressed concerns about environmental issues, only three reported their own initiatives. Other respondents said they faced barriers such as bureaucratic dysfunctions and lack of management support to propose actions related to Green IT.
DOI: 10.6084/m9.figshare.5718694
title: Cervical squamous intraepithelial lesions grades 1 and 2: value of an alternative morphological classification and of p16 immunohistochemistry in the prediction of clinical outcome

description: ABSTRACT Introduction: Diagnostic reproducibility and determination of prognostic factors in cervical intraepithelial neoplasias grades 1 and 2 are still relevant problems in the daily practice of gynecological histopathology. Objective: To correlate the value of morphological reclassification and of p16 immunoexpression in cervical intraepithelial neoplasias grades 1 and 2 with clinical outcome. Materials and methods: Sixty-six patients were included (34 with cervical intraepithelial neoplasia grade 1, and 32 with grade 2); an immunohistochemical study with p16 and reclassification according to the Lower Anogenital Squamous Terminology (LAST) Consensus and by the alternative proposal of Herfs and Crum were done; unfavorable outcome was defined as a subsequent histologic diagnosis of cervical intraepithelial neoplasia grade 3 or invasive squamous cell carcinoma. Results: We observed superior performance of the alternative morphological classification (p = 0.002) to determine unfavorable outcome. We also detected superior performance of p16 in the same determination (p = 0.002). Conclusion: The use of an alternative morphological classification is promising; in the context of the use of immunohistochemical antibodies as biomarkers, p16 showed good sensitivity and negative predictive value in the determination of cases in which the outcome was unfavorable.
DOI: 10.6084/m9.figshare.5718694.v1
title: Cervical squamous intraepithelial lesions grades 1 and 2: value of an alternative morphological classification and of p16 immunohistochemistry in the prediction of clinical outcome

description: ABSTRACT Introduction: Diagnostic reproducibility and determination of prognostic factors in cervical intraepithelial neoplasias grades 1 and 2 are still relevant problems in the daily practice of gynecological histopathology. Objective: To correlate the value of morphological reclassification and of p16 immunoexpression in cervical intraepithelial neoplasias grades 1 and 2 with clinical outcome. Materials and methods: Sixty-six patients were included (34 with cervical intraepithelial neoplasia grade 1, and 32 with grade 2); an immunohistochemical study with p16 and reclassification according to the Lower Anogenital Squamous Terminology (LAST) Consensus and by the alternative proposal of Herfs and Crum were done; unfavorable outcome was defined as a subsequent histologic diagnosis of cervical intraepithelial neoplasia grade 3 or invasive squamous cell carcinoma. Results: We observed superior performance of the alternative morphological classification (p = 0.002) to determine unfavorable outcome. We also detected superior performance of p16 in the same determination (p = 0.002). Conclusion: The use of an alternative morphological classification is promising; in the context of the use of immunohistochemical antibodies as biomarkers, p16 showed good sensitivity and negative predictive value in the determination of cases in which the outcome was unfavorable.
DOI: 10.6084/m9.figshare.5718691
title: Medical Termination of Delayed Miscarriage: Four-Year Experience with an Outpatient Protocol

description: Abstract Purpose To evaluate the efficacy of an outpatient protocol with vaginal misoprostol to treat delayed miscarriage. Methods Retrospective analysis of prospectively collected data on women medically treated for missed abortion with an outpatient protocol. The inclusion criteria were: ultrasound-based diagnosis of missed abortion with less than 10 weeks; no heavy bleeding, infection, inflammatory bowel disease ormisoprostol allergy; nomore than 2 previous spontaneous abortions; the preference of the patient regarding the medical management. The protocol consisted of: 1) a single dose of 800 μg of misoprostol administered intravaginally at the emergency department, after which the patients were discharged home; 2) clinical and ultrasonographic evaluation 48 hours later - if the intrauterine gestational sac was still present, the application of 800 μg of vaginal misoprostol was repeated, and the patients were discharged home; 3) clinical and ultrasonography evaluation 7 days after the initiation of the protocol - if the intrauterine gestational sac was still present, surgical management was proposed. The protocol was introduced in January 2012. Every woman received oral analgesia and written general recommendations. We also gave them a paper form to be presented and filled out at each evaluation. Results Complete miscarriage with misoprostol occurred in 340 women (90.2%). Surgery was performed in 37 (9.8%) patients, representing the global failure rate of the protocol. Miscarriage was completed after the first misoprostol administration in 208 (55.2%) women, with a success rate after the second administration of 78.1% (132/169). The average age of the women with complete resolution using misoprostol was superior to the average age of those who required surgery (33.99 years versus 31.74 years; p = 0.031). Based on the ultrasonographic findings in the first evaluation, the women diagnosed with fetal loss achieved greater success rates compared with those diagnosed with empty sac (p = 0.049). Conclusions We conclude this is an effective and safe option in the majority of delayed miscarriage cases during the first trimester, reducing surgical procedures and their consequences.
DOI: 10.6084/m9.figshare.5718691.v1
title: Medical Termination of Delayed Miscarriage: Four-Year Experience with an Outpatient Protocol

description: Abstract Purpose To evaluate the efficacy of an outpatient protocol with vaginal misoprostol to treat delayed miscarriage. Methods Retrospective analysis of prospectively collected data on women medically treated for missed abortion with an outpatient protocol. The inclusion criteria were: ultrasound-based diagnosis of missed abortion with less than 10 weeks; no heavy bleeding, infection, inflammatory bowel disease ormisoprostol allergy; nomore than 2 previous spontaneous abortions; the preference of the patient regarding the medical management. The protocol consisted of: 1) a single dose of 800 μg of misoprostol administered intravaginally at the emergency department, after which the patients were discharged home; 2) clinical and ultrasonographic evaluation 48 hours later - if the intrauterine gestational sac was still present, the application of 800 μg of vaginal misoprostol was repeated, and the patients were discharged home; 3) clinical and ultrasonography evaluation 7 days after the initiation of the protocol - if the intrauterine gestational sac was still present, surgical management was proposed. The protocol was introduced in January 2012. Every woman received oral analgesia and written general recommendations. We also gave them a paper form to be presented and filled out at each evaluation. Results Complete miscarriage with misoprostol occurred in 340 women (90.2%). Surgery was performed in 37 (9.8%) patients, representing the global failure rate of the protocol. Miscarriage was completed after the first misoprostol administration in 208 (55.2%) women, with a success rate after the second administration of 78.1% (132/169). The average age of the women with complete resolution using misoprostol was superior to the average age of those who required surgery (33.99 years versus 31.74 years; p = 0.031). Based on the ultrasonographic findings in the first evaluation, the women diagnosed with fetal loss achieved greater success rates compared with those diagnosed with empty sac (p = 0.049). Conclusions We conclude this is an effective and safe option in the majority of delayed miscarriage cases during the first trimester, reducing surgical procedures and their consequences.
DOI: 10.6084/m9.figshare.5718688
title: Cultural adaptation of Quality Of Care Through The Patient's Eyes -QUOTE-HIV

description: ABSTRACT Objective: to translate and adapt Quality of Care Through the Patient's Eyes - HIV (QUOTE-HIV) for the Brazilian population living with HIV/AIDS. Method: a methodological study, which followed the stages of translation, synthesis, back-translation, evaluation by the committee of experts and pre-test for cultural adaptation of the instrument. Results: the process of translation and cultural adaptation was considered adequate. Evaluation by the expert committee resulted in semantic, structural and grammatical adequacy of the evaluated items. 30 subjects considered the instrument to be easy to understand and suggested minor adjustments in some items. Conclusion: the Brazilian version of QUOTE-HIV has been adapted and validated in relation to its content. However, this is a study that precedes the process of evaluating the psychometric properties of the instrument, the results of which will be presented in a later publication.
DOI: 10.6084/m9.figshare.5718688.v1
title: Cultural adaptation of Quality Of Care Through The Patient's Eyes -QUOTE-HIV

description: ABSTRACT Objective: to translate and adapt Quality of Care Through the Patient's Eyes - HIV (QUOTE-HIV) for the Brazilian population living with HIV/AIDS. Method: a methodological study, which followed the stages of translation, synthesis, back-translation, evaluation by the committee of experts and pre-test for cultural adaptation of the instrument. Results: the process of translation and cultural adaptation was considered adequate. Evaluation by the expert committee resulted in semantic, structural and grammatical adequacy of the evaluated items. 30 subjects considered the instrument to be easy to understand and suggested minor adjustments in some items. Conclusion: the Brazilian version of QUOTE-HIV has been adapted and validated in relation to its content. However, this is a study that precedes the process of evaluating the psychometric properties of the instrument, the results of which will be presented in a later publication.
DOI: 10.6084/m9.figshare.5718679
title: Factors that make up safety culture: a look at mining industry

description: Abstract The efforts made by researchers to understand the dynamics of work-related accident prevention are remarkable but not enough to exhaust the subject. The occurrence of such events implies significant losses for society, organizations and families, in addition to the injured individuals subject to the accident. This kind of phenomenon that still happens in contemporary organizations requires not only a purely mechanistic view but also the understanding of interpersonal relations in the employment context, which refers to the organizational culture. As a quantitative analysis, this study aimed to test a model related to the culture of safety in workplace, present in the literature, in the Brazilian mining industry. Based on the initial results and on the requirements pointed out by a group of security experts in this field, we suggested adjustments in the model and it was re-tested. The results confirmed the model applied in this study and they indicated that factors related to the culture of safety in this specific environment are organizational learning, information and commitment.
DOI: 10.6084/m9.figshare.5718679.v1
title: Factors that make up safety culture: a look at mining industry

description: Abstract The efforts made by researchers to understand the dynamics of work-related accident prevention are remarkable but not enough to exhaust the subject. The occurrence of such events implies significant losses for society, organizations and families, in addition to the injured individuals subject to the accident. This kind of phenomenon that still happens in contemporary organizations requires not only a purely mechanistic view but also the understanding of interpersonal relations in the employment context, which refers to the organizational culture. As a quantitative analysis, this study aimed to test a model related to the culture of safety in workplace, present in the literature, in the Brazilian mining industry. Based on the initial results and on the requirements pointed out by a group of security experts in this field, we suggested adjustments in the model and it was re-tested. The results confirmed the model applied in this study and they indicated that factors related to the culture of safety in this specific environment are organizational learning, information and commitment.
DOI: 10.6084/m9.figshare.5718676
title: One Abutment at One Time Concept for Platform-Switched Morse Implants: Systematic Review and Meta-Analysis

description: Abstract The aim of this systematic review and meta-analysis was to compare the peri-implant vertical bone loss of immediate loading of implant crowns using the one abutment at one time (AOT) protocol and implants with abutment removal (AR). This systematic review with meta-analysis was reported according to the PRISMA statement, with guidance from the Cochrane Collaboration Handbook. A total of 103 publications were identified in the PubMed database and reference lists of examined articles. After the screening of titles and abstracts, the eligibility of eight full-text articles was assessed. Five studies published between 2010 and 2015 were included in the meta-analysis. There was less peri-implant vertical bone loss at implants using an AOT protocol than at implants using AR protocol (WMD -0.19, 95% CI -0.26 to -0.13; p&lt;0.0001; random-effects model). In conclusion, the use of the AOT protocol with platform-switched Morse implants results in less bone loss than do AR procedures, but this effect may not be clinically relevant. The preservation of marginal bone level achieved with the AOT protocol may not enhance the aesthetics. These results should be interpreted with caution.