cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.7910/dvn/owe9cv/jbbaav
title: 2_tables.log

description: log file from table replication
DOI: 10.7910/dvn/owe9cv/jjmvso
title: heuristics_data.tab

description: Data for heuristics estimation
DOI: 10.7910/dvn/zsqjom/1pp8vg
title: political_parties.tab

description: Data file that contains the party of the municipal president and state governor.
 Source: Own calculations, based on election data from Banamex, the Mexican electoral calendar, and legislative dates for taking office.
DOI: 10.7910/dvn/zsqjom/6gytdd
title: low_risk_cae.tab

description: Data file that contains the list of industries that were eligible for SARE.
 Source: I created this file myself, based on information from COFEMER. I hand-matched industry names from a list provided by
 COFEMER to industry names in the CAE industry classification.
DOI: 10.7910/dvn/zsqjom/ciaysk
title: census_data.tab

description: Data file that contains data from the 1999 Economic Census and 2000 Demographic Census.
 Source: INEGI website.
DOI: 10.7910/dvn/zsqjom/xzswmw
title: creating_dataset.do

description: Stata do file that reads in the raw data files and creates the dataset used in the paper
DOI: 10.7910/dvn/zsqjom/yduwtj
title: prices_quarterly.tab

description: Data file that contains the quarterly average of the main index in the prices.dta
 Source: Own calculations based on CPI data from Banxico website
DOI: 10.7910/dvn/nngpmj/9hv2ig
title: table4.out

description: Output file
DOI: 10.7910/dvn/nngpmj/gdijwv
title: table6.out

description: Output file
DOI: 10.7910/dvn/nngpmj/hhpmji
title: table5.out

description: Output file
DOI: 10.7910/dvn/nngpmj/knewuq
title: table3.out

description: Output file
DOI: 10.7910/dvn/nngpmj/ntpvws
title: table6_caste.tab

description: Stata 11 data file for Table 6
DOI: 10.7910/dvn/nngpmj/xa0v4y
title: table2.tab

description: Stata 11 data file for Tables 1-6
DOI: 10.7910/dvn/owe9cv/4orvqv
title: readme.docx

description: Read me file
DOI: 10.7910/dvn/owe9cv/bexmps
title: main_experiment_raw_data.tab

description: Raw data for the main experiment
DOI: 10.7910/dvn/owe9cv/h4n3wk
title: table2.tab

description: Table 2
DOI: 10.7910/dvn/owe9cv/hc0xf5
title: table12.tab

description: Table 12
DOI: 10.7910/dvn/owe9cv/kmdc1o
title: table5.tab

description: Table 5
DOI: 10.7910/dvn/owe9cv/susqui
title: table3.tab

description: Table 3
DOI: 10.7910/dvn/zsqjom/bmuhsr
title: prices.tab

description: Data file that contains the data for the price regressions.
 Source: Own caculations (as explained in the Readme file) based on CPI data from the Mexican Central Bank (Banxico) website
DOI: 10.7910/dvn/zsqjom/enkhnl
title: Readme.txt

description: Readme file
DOI: 10.7910/dvn/zsqjom/iyvryo
title: sare.tab

description: Data file that contains information on the implementation of the reform (SARE) studied in this paper. Source: I created this file myself, based on information from COFEMER.
DOI: 10.7910/dvn/zsqjom/oagt1h
title: tables_and_figures.do

description: Stata do file that contains the code for replicating tables and figures in the paper
DOI: 10.7910/dvn/zsqjom/wrn03g
title: tables_and_figures.log

description: Log file that contains the output from running the Stata do file tables_and_figures.do
DOI: 10.7910/dvn/nngpmj/3pkywe
title: table7.out

description: Output file
DOI: 10.7910/dvn/nngpmj/lwm3yu
title: table8a.tab

description: Stata 11 data file for Table 8
DOI: 10.7910/dvn/nngpmj/nleiz4
title: table8.out

description: Output file
DOI: 10.7910/dvn/nngpmj/sjrezg
title: table7.tab

description: Stata 11 data file for Table 7
DOI: 10.7910/dvn/nngpmj/vsmgru
title: table8b.tab

description: Stata 11 data file for Table 8
DOI: 10.7910/dvn/nngpmj/y8m2h7
title: table8c.tab

description: Stata 11 data file for Table 8
DOI: 10.7910/dvn/owe9cv/5xzlta
title: validation_experiment_data.tab

description: Raw data for the validation experiment
DOI: 10.7910/dvn/owe9cv/ncldx4
title: table7.tab

description: Table 7
DOI: 10.7910/dvn/owe9cv/rgut9f
title: table9.tab

description: Table 9
DOI: 10.7910/dvn/owe9cv/vhn7qd
title: table8.tab

description: Table 8
DOI: 10.7910/dvn/eblgok/14sisy
title: Appendix_Fig_A1_B.do
DOI: 10.7910/dvn/eblgok/bv07pt
title: data_event_study_before_estimation_T_180_30_thin0_majorinitiative1summit.dta
DOI: 10.7910/dvn/eblgok/cys7cp
title: Appendix_Fig_A1_C.do
DOI: 10.7910/dvn/eblgok/jalupl
title: Creation of Files.zip

description: Data files and programs used to create the data files directly used to produce tables and figures (see Readme.txt)
DOI: 10.7910/dvn/eblgok/jeot99
title: Appendix_Fig_A1_A.do
DOI: 10.7910/dvn/eblgok/r9snbr
title: data_event_study_before_estimation_T_180_30_thin0_decevent.dta
DOI: 10.7910/dvn/eblgok/slvv4v
title: data_event_study_before_estimation_T_180_30_thin0_compevent_1.dta
DOI: 10.7910/dvn/nngpmj/mrydtl
title: up_ut_cmcaste.tab

description: Stata 11 data file
DOI: 10.7910/dvn/26093/d9r98v
title: forrestat.do
DOI: 10.7910/dvn/26093/iga4jd
title: readme.txt
DOI: 10.7910/dvn/26093/weerox
title: risk_forrep.tab
DOI: 10.7910/dvn/eblgok/4kzrkg
title: Data_Event_Study_final_thin0_est180_evt30_control1_ind1_compevent.dta
DOI: 10.7910/dvn/eblgok/9l35uo
title: Data_HIPC_events.tab
DOI: 10.7910/dvn/eblgok/fnywo4
title: Data_Event_Study_final_thin0_est180_evt30_control1_ind1_majorinitiative1summit.dta
DOI: 10.7910/dvn/eblgok/jck6ci
title: data_event_study_before_estimation_T_180_30_thin0_majorinitiative2alt.dta
DOI: 10.7910/dvn/eblgok/o4q3ja
title: Data_Event_Study_final_thin0_est180_evt30_control1_ind1_decevent.dta
DOI: 10.7910/dvn/eblgok/toppjh
title: data_event_study_before_estimation_T_180_30_thin1_majorinitiative1summit.dta
DOI: 10.7910/dvn/eblgok/fqyrxq
title: Distribution_dates_news_2005.dta
DOI: 10.7910/dvn/eblgok/iqbz7l
title: Distribution_dates_news_1996.dta
DOI: 10.7910/dvn/eblgok/pzzp0m
title: Distribution_dates_news_1999.dta
DOI: 10.7910/dvn/eblgok/v41nt7
title: employment_per_year_parents_imputed.dta
DOI: 10.7910/dvn/eblgok/wdlqxy
title: employment_parents.dta
DOI: 10.7910/dvn/eblgok/7t2vle
title: Figure_3_&_Table_4.do
DOI: 10.7910/dvn/eblgok/ahktbv
title: Figure_2.do
DOI: 10.7910/dvn/eblgok/fhecep
title: Figure_10_A.do
DOI: 10.7910/dvn/eblgok/fmqpk6
title: Figure_4.do
DOI: 10.7910/dvn/eblgok/jqinpb
title: Figure_10_B.do
DOI: 10.7910/dvn/eblgok/l23nqu
title: Figure_10_C.do
DOI: 10.7910/dvn/eblgok/pqul98
title: Figure_1.do
DOI: 10.7910/dvn/28641/cugclg
title: dofile10_npi_human5_final_analysis.do
DOI: 10.7910/dvn/28641/fk6ari
title: dofile1_npi_merge_tables_db05.do
DOI: 10.7910/dvn/28641/tmjr6p
title: dofile2_npi_merge_tables_db06.do
DOI: 10.7910/dvn/eblgok/03ocei
title: Figure_5_&_Table_5_A.do
DOI: 10.7910/dvn/eblgok/1yg5cf
title: Figure_8_A.do
DOI: 10.7910/dvn/eblgok/mmfb4u
title: Figure_7.do
DOI: 10.7910/dvn/eblgok/pd6dnf
title: Figure_6_&_Table_5_B.do
DOI: 10.7910/dvn/eblgok/ser8ko
title: Figure_8_B.do
DOI: 10.7910/dvn/28641/himm8z
title: dofile3_npi_merge_tables_db07.do
DOI: 10.7910/dvn/28641/iky2i8
title: dofile4_npi_merge_db.do
DOI: 10.7910/dvn/28641/jq7vjo
title: dofile6_npi_human1_2.do
DOI: 10.7910/dvn/28641/krurhn
title: dofile7_npi_human3_4.do
DOI: 10.7910/dvn/28641/lvozlm
title: dofile8_npi_human4_potentrants.do
DOI: 10.7910/dvn/28641/yttv3f
title: dofile5_patent_spc_merge_tables.do
DOI: 10.7910/dvn/eblgok/1tdrwl
title: Readme.txt

description: MUST READ: Detailed description of all files in folder and how to reproduce the tables and figures of analysis in the paper.
DOI: 10.7910/dvn/eblgok/7lx384
title: Figure_9_C.do
DOI: 10.7910/dvn/eblgok/9ozxxr
title: Table_6_C1.do
DOI: 10.7910/dvn/eblgok/fesvv1
title: Subsidiaries_employment_adjusted_holdings.dta
DOI: 10.7910/dvn/eblgok/ilrj3d
title: Figure_9_A_B.do
DOI: 10.7910/dvn/eblgok/propua
title: Table_6_C2.do
DOI: 10.7910/dvn/28641/8p8pvj
title: dofile_npi_extract_tables_db07.do
DOI: 10.7910/dvn/28641/cboj28
title: dofile9_npi_human5_final.do
DOI: 10.7910/dvn/28641/fi8rno
title: dofile_npi_extract_tables_db05.do
DOI: 10.7910/dvn/28641/rrvtil
title: dofile_master.ascii
DOI: 10.7910/dvn/28641/vm5js0
title: dofile_npi_extract_tables_db06.do
DOI: 10.7910/dvn/28641/xj8ojg
title: dofile_master.do
DOI: 10.7910/dvn/eblgok/51cpd5
title: Table_6_C4.do
DOI: 10.7910/dvn/eblgok/r0b4po
title: Table_6_C3.do
DOI: 10.7910/dvn/23186/burr31
title: 0_fichier_ACEMO.SAS
DOI: 10.7910/dvn/23186/kr6vse
title: 1_Fusion ACEMO EC.sas
DOI: 10.7910/dvn/23186/ifpcc6
title: 3_Descriptive_Stats.sas
DOI: 10.7910/dvn/23186/pqn9f1
title: 4_Ordered_probit_qualit3_prod.do
DOI: 10.7910/dvn/23186/r8joww
title: 5_Ordered_probit_qualit3_shocks.do
DOI: 10.7910/dvn/23186/sfgqs6
title: 3_Descriptive_Stats.lst
DOI: 10.7910/dvn/23186/ubgrbz
title: 2_Fichier_final.sas
DOI: 10.7910/dvn/23186/zeqmz1
title: 4_ordered_probit_qualit3_prod.log
DOI: 10.15468/dl.qukazr
title: Occurrence Download

description: A dataset containing 3880 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Plantae",
 "HasGeospatialIssue is false",
 "HasCoordinate is true",
 "OccurrenceStatus is Present",
 "Country is Germany",
 "DecimalLongitude is greater than or equal to 6.59756321107036",
 "DecimalLongitude is less than 6.60062276425475",
 "DecimalLatitude is greater than or equal to 47.27011",
 "DecimalLatitude is less than or equal to 55.05864"
 ]
}

 The dataset includes 3880 records from 21 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0025674-241007104925546/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.13144/lil-1483
title: Base permanente des équipements - 2020

description: La Base Permanente des Equipements propose annuellement une base d'équipements et de services finement localisés construite à partir de sources administratives diverses. La base est alimentée par de grands répertoires administratives : FINESS (FIchier National des Établissements Sanitaires et Sociaux) également géré par la Drees du ministère de la santé ; RPPS (Répertoire Partagé des Professionnels de Santé) géré par les conseils de l'ordre des professions réglementées ; RAMSESE (Répertoire Académique et Ministériel sur les Etablissements du Système Éducatif) géré par la direction de l'évaluation, de la prospective et de la performance (Depp) du ministère en charge de l'éducation ; SIRENE (Système Informatique pour le Répertoire des ENtreprises et leurs Établissements) géré par l'Insee ; RES (Recensement des Équipements Sportifs), réalisé par le ministère des sports concernant les équipements sportifs et de loisirs.Ainsi que par divers fichiers administratifs de : Gendarmerie Nationale (Ministère de la Défense), Enquêtes Hôtel et Camping (Insee), Préfecture de police de Paris, DGER (Ministère de l'Agriculture),SRJ (Ministère de la Justice), La Poste, ARTCENA, Pôle Emploi, Base du Ministère de l'Économie pour les carburants, DGAC (Direction Générale de l'Aviation Civile), Fichier SNCF. En raison des règles de gestion CNAF, les données de cette source sont décalées d'une année par rapport aux autres sources de la BPE (le millésime 2020 correspond donc aux données au 01/01/2019 et non à celles au 01/01/2020). Les coordonnées XY des équipements sont fournies lorsque la géolocalisation a été possible, en France métropolitaine et dans les DOM. La géolocalisation repose sur le RIL (Répertoire d'immeubles localisés), les services fiscaux et les coordonnées fournies par certains producteurs (sports, gares, enseignement agricole, stations-services, transport, grandes surfaces et commerces alimentaires). Un indicateur de qualité de ces XY leur est également associé. Les fichiers de la base sont répartis en 2 jeux de données : des fichiers d'équipements localisés à la commune/iris ou géolocalisés et des fichiers de localités, communes ou Iris. L'information contenue dans ces 2 jeux de données est presque la même, aux coordonnées XY près. Ils différent simplement par la façon de travailler sur les équipements et les localisations. Les équipements étant répartis en 3 groupes, le produit regroupe donc 12 fichiers.
DOI: 10.5281/zenodo.10776074
title: ICASA Excel data template
DOI: 10.5281/zenodo.10776075
title: ICASA Excel data template
DOI: 10.17026/ar/lmidiw
title: PAN-00103877 - coin/coin-related, provincie, duit

description: &lt;p&gt;This find is registered at Portable Antiquities of the Netherlands with number PAN-00103877&lt;/p&gt;
description: Modified: 2025-07-29T09:21:03+02:00
DOI: 10.15468/dl.vez53a
title: Occurrence Download

description: A dataset containing 1129 species occurrences available in GBIF matching the query:
{
 "and" : [
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "Issue is one of (Coordinate rounded, Geodetic datum assumed WGS84, Continent derived from coordinates, Occurrence status inferred from individual count)",
 "TaxonKey is Carlia fusca"
 ]
}

 The dataset includes 1129 records from 21 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0055609-251120083545085/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.6f53tv
title: Occurrence Download

description: A dataset containing 1720767 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is China",
 "Geometry POLYGON((96 37,127 37,127 54,96 54,96 37))",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "Year 1990-2025"
 ]
}

 The dataset includes 1720767 records from 536 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0055594-251120083545085/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.d63fbw
title: Occurrence Download

description: A dataset containing 56615771 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is United States of America",
 "DatasetKey is iNaturalist Research-grade Observations",
 "HasCoordinate is true",
 "HasGeospatialIssue is false"
 ]
}

 The dataset includes 56615771 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0055604-251120083545085/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.7910/dvn/zanmmj
title: PDB: 6BFS, GM-CSF in complex with autoantibody F1 (311K, 38°C, 100 ns): random seed #3

description: PDB: 6BFS, GM-CSF in complex with autoantibody F1 (311K, 38°C, 100 ns): random seed #3.
PDBs obtained every 50 ns. Contains files with the free binding energy calculations.
DOI: 10.15468/dl.cabdcf
title: Occurrence Download

description: A dataset containing 41 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is China",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "TaxonKey is Accipiter gentilis"
 ]
}

 The dataset includes 41 records from 10 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0055610-251120083545085/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.5281/zenodo.17958145
title: Data and Code for Stream Network Hysteresis Study Using DHSVM in Sagehen Creek Basin

description: This repository includes processing scripts, model code, and data related to a stream network study in Sagehen Creek Basin, California, USA. The DHSVM hydrology model was overhauled to implement a fully coupled surface-groundwater interaction scheme. The model predicts a groundwater hysteresis effect that manifests in the active (flowing) stream network configuration, and this hysteresis effect is supported by geochemical analyses.

Contents:



Code: scripts used for data processing and figure generation

Model: modified version of DHSVM used for this study (https://github.com/eli-mtnhydro/DHSVM-MtnHydro)

Data: model config/output and ancillary data
DOI: 10.5281/zenodo.17958146
title: Data and Code for Stream Network Hysteresis Study Using DHSVM in Sagehen Creek Basin

description: This repository includes processing scripts, model code, and data related to a stream network study in Sagehen Creek Basin, California, USA. The DHSVM hydrology model was overhauled to implement a fully coupled surface-groundwater interaction scheme. The model predicts a groundwater hysteresis effect that manifests in the active (flowing) stream network configuration, and this hysteresis effect is supported by geochemical analyses.

Contents:



Code: scripts used for data processing and figure generation

Model: modified version of DHSVM used for this study (https://github.com/eli-mtnhydro/DHSVM-MtnHydro)

Data: model config/output and ancillary data
DOI: 10.15468/dl.23kdzd
title: Occurrence Download

description: A dataset containing 1213 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Carabus maeander"
 ]
}

 The dataset includes 1213 records from 56 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0055611-251120083545085/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.5281/zenodo.17864757
title: Plasma circRNAs as potential biomarkers to assist in the diagnosis of postpartum depression

description: Abstract

Background: This research sought to examine alterations in plasma circular RNA (circRNA) expression in women with postpartum depressive disorder (PPD), assessing its potential utility as an auxiliary diagnostic biomarker for this condition.

Methods: Women examined at 42 days postpartum were recruited between June 2024 and December 2024, during which plasma samples and relevant data were collected. A discovery cohort was established, consisting of 3 women with PPD and 3 controls. This was followed by a validation cohort of 50 women with PPD and 50 controls, who were identified using the Structured Clinical Interview. The discovery cohort underwent plasma circRNA microarray analysis, while the validation cohort used Reverse Transcription Quantitative Polymerase Chain Reaction (RT-qPCR) to quantify candidate circRNAs, additionally including five circRNAs associated with major depressive disorder (MDD).

Results: Plasma levels of circIFNGR2, circABCC5, and circATF7IP were significantly up-regulated in the PPD group, and circDYM were significantly down-regulated (p < 0.05). The area under the curve (AUC) of the four circRNAs - circIFNGR2, circABCC5, circDYM, and circATF7IP was 0.62 [sensitivity 28%, specificity 96%], 0.64 [sensitivity 36%, specificity 96%], 0.69 [sensitivity 54%, specificity 84%], and 0.65 [sensitivity 62%, specificity 72%], respectively. The joint AUC of circIFNGR2, circABCC5, circDYM, and circATF7IP was 0.80 [sensitivity 78%, specificity 70%]. Adjusting for covariates reveals that circIFNGR2, circABCC5, and circDYM were relatively independent predictive factors.

Conclusion: Changes in the levels of circIFNGR2, circABCC5 (microarray-related), circDYM, and circATF7IP (MDD-related) are associated with the occurrence of PPD. Our results support the potential utility of circRNAs as adjunct diagnostic biomarkers for PPD and offer valuable insights into the molecular underpinnings of the disorder.
DOI: 10.17026/ar/pyeyok
title: PAN-00127686 - coin/coin-related, Gallische tegenkeizer (?), naar, antoninianus

description: &lt;p&gt;This find is registered at Portable Antiquities of the Netherlands with number PAN-00127686&lt;/p&gt;
description: Modified: 2025-10-21T11:20:12+02:00
DOI: 10.6084/m9.figshare.30655791
title: Plumbagin disrupts the mature biofilm of <i>Staphylococcus aureus</i>

description: Plumbagin, also known as 5-hydroxy-2-methyl-1,4-naphthoquinone (PLB), is a naturally occurring naphthoquinone molecule that has demonstrated strong antibacterial and antibiofilm properties against <i>Staphylococcus aureus</i> (<i>S. aureus</i>). However, the potential of PLB to eradicate mature biofilms and the underlying mechanisms involved remain unclear. In this study explored the effects of PLB on disrupting mature <i>S. aureus</i> biofilms, focusing on its impact on the extracellular polymeric substances (EPS) and potential mechanisms of action. Crystal violet (CV) and XTT assays demonstrated that PLB significantly reduced both the biomass and metabolic activity of mature <i>S. aureus</i> biofilms in a concentration-dependent manner. High-content screening (HCS) imaging demonstrated that PLB treatment induced significant alterations in the biofilm EPS architecture, leading to a substantial reduction in overall biomass and average thickness, with disruption severity correlating positively with PLB concentration. Using molecular fluorescence probing techniques, this study found that treatment with PLB resulted in a marked reduction in EPS components, including extracellular polysaccharides (PIA), proteins, and extracellular DNA (eDNA), compared to untreated controls. Molecular docking analysis revealed that PLB strongly interacts with several key <i>S. aureus</i> proteins involved in EPS production, such as IcaA, IcaD, IcaB, IcaC, Bap, ClfB, and CidA, particularly binding strongly to the active sites of IcaA and Bap. Furthermore, gene expression analysis indicated that PLB downregulated genes associated with biofilm EPS production. Overall, these findings suggest that PLB effectively disrupts <i>S. aureus</i> biofilms by targeting the EPS. These results highlight PLB as a promising candidate for targeting mature <i>S. aureus</i> biofilms in chronic infections.
DOI: 10.6084/m9.figshare.30655791.v1
title: Plumbagin disrupts the mature biofilm of <i>Staphylococcus aureus</i>

description: Plumbagin, also known as 5-hydroxy-2-methyl-1,4-naphthoquinone (PLB), is a naturally occurring naphthoquinone molecule that has demonstrated strong antibacterial and antibiofilm properties against <i>Staphylococcus aureus</i> (<i>S. aureus</i>). However, the potential of PLB to eradicate mature biofilms and the underlying mechanisms involved remain unclear. In this study explored the effects of PLB on disrupting mature <i>S. aureus</i> biofilms, focusing on its impact on the extracellular polymeric substances (EPS) and potential mechanisms of action. Crystal violet (CV) and XTT assays demonstrated that PLB significantly reduced both the biomass and metabolic activity of mature <i>S. aureus</i> biofilms in a concentration-dependent manner. High-content screening (HCS) imaging demonstrated that PLB treatment induced significant alterations in the biofilm EPS architecture, leading to a substantial reduction in overall biomass and average thickness, with disruption severity correlating positively with PLB concentration. Using molecular fluorescence probing techniques, this study found that treatment with PLB resulted in a marked reduction in EPS components, including extracellular polysaccharides (PIA), proteins, and extracellular DNA (eDNA), compared to untreated controls. Molecular docking analysis revealed that PLB strongly interacts with several key <i>S. aureus</i> proteins involved in EPS production, such as IcaA, IcaD, IcaB, IcaC, Bap, ClfB, and CidA, particularly binding strongly to the active sites of IcaA and Bap. Furthermore, gene expression analysis indicated that PLB downregulated genes associated with biofilm EPS production. Overall, these findings suggest that PLB effectively disrupts <i>S. aureus</i> biofilms by targeting the EPS. These results highlight PLB as a promising candidate for targeting mature <i>S. aureus</i> biofilms in chronic infections.
DOI: 10.7910/dvn/z1chpb
title: PDB: 6BFS, GM-CSF in complex with autoantibody F1 (311K, 38°C, 100 ns): random seed #2

description: PDB: 6BFS, GM-CSF in complex with autoantibody F1 (311K, 38°C, 100 ns): random seed #2.
PDBs obtained every 50 ns. Contains files with the free binding energy calculations.
DOI: 10.17026/ar/rjvpxu
title: PAN-00126796 - coin/coin-related, Domitianus (81-96), as

description: &lt;p&gt;This find is registered at Portable Antiquities of the Netherlands with number PAN-00126796&lt;/p&gt;
description: Modified: 2025-09-30T07:59:26+02:00