cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.12489824
title: Supplementary Material for: Adjustment of Stent Retriever Length to Clot Extent Affects First-Pass Reperfusion in Endovascular Treatment of Acute Ischemic Stroke

description: <b><i>Background:</i></b> Stent retriever technology has evolved, and significantly longer devices have become available for mechanical thrombectomy (MT) of large cerebral vessel occlusions in ischemic stroke. We hypothesized that increased stent retriever length may improve the rate of complete angiographic reperfusion and decrease the respective number of attempts, resulting in a better clinical outcome. <b><i>Methods:</i></b> Retrospective analysis of patients with large vessel occlusion in the anterior and posterior circulation treated with stent retriever MT. The study group was dichotomized into short (20 mm) and long (&gt;20 mm) retrievers using propensity matching. In the anterior circulation, the clot burden score was evaluated. Primary end points were first-pass modified thrombolysis in cerebral infarction (mTICI) 3 reperfusion and first-pass mTICI ≥ 2b reperfusion, and the secondary end point was functional independence (defined as modified Rankin Scale score 0–2) at discharge and 90 days. <b><i>Results:</i></b> Overall, 394 patients were included in the analysis. In the anterior circulation, short stent retrievers had a significantly higher rate of first-pass reperfusion in cases with low clot burden (mTICI 3: 27% vs. 17%; <i>p</i> = 0.009; mTICI ≥ 2b: 42 vs. 30%; <i>p</i> = 0.005) and in middle cerebral artery occlusions (mTICI ≥ 2b: 51 vs. 41%; <i>p</i> = 0.024). Higher rates of favorable outcome at discharge and 90 days were observed for the short stent retriever group (<i>p</i> &lt; 0.001). <b><i>Conclusion:</i></b> Stent retriever length should be adjusted to clot burden score and vessel occlusion site.
DOI: 10.6084/m9.figshare.12489872
title: Supplementary Material for: Diffusion-Weighted Imaging-Fluid-Attenuated Inversion Recovery Mismatch Is Associated with 90-Day Functional Outcomes in Patients Undergoing Mechanical Thrombectomy

description: <b><i>Background and Purpose:</i></b> Diffusion-weighted imaging-fluid-attenuated inversion recovery (DWI-FLAIR) mismatch is an early sign of acute ischemic stroke. DWI-FLAIR mismatch was reported to be valuable to select patients with unknown onset stroke who are eligible to receive intravenous thrombolysis (IVT), but its utility is less studied in patients undergoing mechanical thrombectomy (MT) for acute large vessel occlusion (LVO). We thus investigated the functional outcomes at 90 days between patients with DWI-FLAIR mismatch and those with match who underwent MT for LVO. <b><i>Methods:</i></b> We conducted a historical cohort study in consecutive patients who were evaluated by magnetic resonance imaging for suspected stroke at a single center. We enrolled patients with occlusion of internal carotid artery or horizontal or vertical segment of middle cerebral artery who underwent MT within 24 h after they were last known to be well. DWI-FLAIR mismatch was defined when a visible acute ischemic lesion was present on DWI without traceable parenchymal hyperintensity on FLAIR. Image analysis was done by 2 stroke neurologists independently. We estimated the adjusted odds ratio (OR) of DWI-FLAIR mismatch relative to DWI-FLAIR match for moderate outcome defined as modified Rankin Scale (mRS) 0–3, favorable outcome defined as mRS 0–2 and mortality at 90 days after the onset, and symptomatic intracranial hemorrhage (sICH) within 72 h after the onset. <b><i>Results:</i></b> Of the 380 patients who received MT, 202 were included. Patients with DWI-FLAIR mismatch (146 [72%]) had significantly higher baseline National Institutes of Health Stroke Scale (median 16 vs. 13, <i>p</i> = 0.01), more transferred-in (78 vs. 63%, <i>p</i> = 0.02), more IVT (45 vs. 18%, <i>p</i> = 0.0003), more cardioembolism (69 vs. 54%, <i>p</i> = 0.03), and shorter onset-to-hospital door times (median 175 vs. 371 min, <i>p</i> &lt; 0.0001) than patients with DWI-FLAIR match. Patients with DWI-FLAIR mismatch had more moderate outcome than those with DWI-FLAIR match (61 vs. 52%, <i>p</i> = 0.24), and the adjusted OR was 3.12 (95% confidence interval [CI]: 1.35–7.19, <i>p</i> = 0.008). sICH within 72 h was less frequent in the DWI-FLAIR mismatch group (10 vs. 20%, <i>p</i> = 0.06), with an adjusted OR of 0.36 (95% CI: 0.13–0.97, <i>p</i> = 0.044). The adjusted ORs for favorable outcome and mortality were 0.87 (95% CI: 0.39–1.94, <i>p</i> = 0.73) and 0.63 (95% CI: 0.20–2.05, <i>p</i> = 0.44), respectively. <b><i>Conclusions:</i></b> DWI-FLAIR mismatch was associated with more moderate outcome and less sICH in the adjusted analysis in patients receiving MT for acute LVO. DWI-FLAIR mismatch could be useful to select patients with unknown onset stroke who are eligible to receive MT for acute LVO.
DOI: 10.6084/m9.figshare.12489956.v1
title: R code from Mobility and its sensitivity to fitness differences determine consumer–resource distributions

description: An animal's movement rate (mobility) and its ability to perceive fitness gradients (fitness sensitivity) determine how well it can exploit resources. Previous models have examined mobility and fitness sensitivity separately and found that mobility, modelled as random movement, prevents animals from staying in high-quality patches, leading to a departure from an ideal free distribution (IFD). However, empirical work shows that animals with higher mobility can more effectively collect environmental information and better sense patch quality, especially when the environment is frequently changed by human activities. Here, we model, for the first time, this positive correlation between mobility and fitness sensitivity and measure its consequences for the populations of a consumer and its resource. In the absence of consumer demography, mobility alone had no effect on system equilibria, but a positive correlation between mobility and fitness sensitivity could produce an IFD. In the presence of consumer demography, lower levels of mobility prevented the system from approaching an IFD due to the mixing of consumers between patches. However, when positively correlated with fitness sensitivity, high mobility led to an IFD. Our study demonstrates that the expected covariation of animal movement attributes can drive broadly theorized consumer–resource patterns across space and time and could underlie the role of consumers in driving spatial heterogeneity in resource abundance.
DOI: 10.6084/m9.figshare.12489872.v1
title: Supplementary Material for: Diffusion-Weighted Imaging-Fluid-Attenuated Inversion Recovery Mismatch Is Associated with 90-Day Functional Outcomes in Patients Undergoing Mechanical Thrombectomy

description: <b><i>Background and Purpose:</i></b> Diffusion-weighted imaging-fluid-attenuated inversion recovery (DWI-FLAIR) mismatch is an early sign of acute ischemic stroke. DWI-FLAIR mismatch was reported to be valuable to select patients with unknown onset stroke who are eligible to receive intravenous thrombolysis (IVT), but its utility is less studied in patients undergoing mechanical thrombectomy (MT) for acute large vessel occlusion (LVO). We thus investigated the functional outcomes at 90 days between patients with DWI-FLAIR mismatch and those with match who underwent MT for LVO. <b><i>Methods:</i></b> We conducted a historical cohort study in consecutive patients who were evaluated by magnetic resonance imaging for suspected stroke at a single center. We enrolled patients with occlusion of internal carotid artery or horizontal or vertical segment of middle cerebral artery who underwent MT within 24 h after they were last known to be well. DWI-FLAIR mismatch was defined when a visible acute ischemic lesion was present on DWI without traceable parenchymal hyperintensity on FLAIR. Image analysis was done by 2 stroke neurologists independently. We estimated the adjusted odds ratio (OR) of DWI-FLAIR mismatch relative to DWI-FLAIR match for moderate outcome defined as modified Rankin Scale (mRS) 0–3, favorable outcome defined as mRS 0–2 and mortality at 90 days after the onset, and symptomatic intracranial hemorrhage (sICH) within 72 h after the onset. <b><i>Results:</i></b> Of the 380 patients who received MT, 202 were included. Patients with DWI-FLAIR mismatch (146 [72%]) had significantly higher baseline National Institutes of Health Stroke Scale (median 16 vs. 13, <i>p</i> = 0.01), more transferred-in (78 vs. 63%, <i>p</i> = 0.02), more IVT (45 vs. 18%, <i>p</i> = 0.0003), more cardioembolism (69 vs. 54%, <i>p</i> = 0.03), and shorter onset-to-hospital door times (median 175 vs. 371 min, <i>p</i> &lt; 0.0001) than patients with DWI-FLAIR match. Patients with DWI-FLAIR mismatch had more moderate outcome than those with DWI-FLAIR match (61 vs. 52%, <i>p</i> = 0.24), and the adjusted OR was 3.12 (95% confidence interval [CI]: 1.35–7.19, <i>p</i> = 0.008). sICH within 72 h was less frequent in the DWI-FLAIR mismatch group (10 vs. 20%, <i>p</i> = 0.06), with an adjusted OR of 0.36 (95% CI: 0.13–0.97, <i>p</i> = 0.044). The adjusted ORs for favorable outcome and mortality were 0.87 (95% CI: 0.39–1.94, <i>p</i> = 0.73) and 0.63 (95% CI: 0.20–2.05, <i>p</i> = 0.44), respectively. <b><i>Conclusions:</i></b> DWI-FLAIR mismatch was associated with more moderate outcome and less sICH in the adjusted analysis in patients receiving MT for acute LVO. DWI-FLAIR mismatch could be useful to select patients with unknown onset stroke who are eligible to receive MT for acute LVO.
DOI: 10.6084/m9.figshare.12489749
title: Supplementary Material for: Efficacy and Moderators of Internet-Based Interventions in Adults with Subthreshold Depression: An Individual Participant Data Meta-Analysis of Randomized Controlled Trials

description: <b><i>Introduction:</i></b> Evidence on effects of Internet-based interventions to treat subthreshold depression (sD) and prevent the onset of major depression (MDD) is inconsistent. <b><i>Objective:</i></b> We conducted an individual participant data meta-analysis to determine differences between intervention and control groups (IG, CG) in depressive symptom severity (DSS), treatment response, close to symptom-free status, symptom deterioration and MDD onset as well as moderators of intervention outcomes. <b><i>Methods:</i></b> Randomized controlled trials were identified through systematic searches via PubMed, PsycINFO, Embase and Cochrane Library. Multilevel regression analyses were used to examine efficacy and moderators. <b><i>Results:</i></b> Seven trials (2,186 participants) were included. The IG was superior in DSS at all measurement points (posttreatment: 6–12 weeks; Hedges’ g = 0.39 [95% CI: 0.25–0.53]; follow-up 1: 3–6 months; g = 0.30 [95% CI: 0.15–0.45]; follow-up 2: 12 months, g = 0.27 [95% CI: 0.07–0.47], compared with the CG. Significantly more participants in the IG than in the CG reached response and close to symptom-free status at all measurement points. A significant difference in symptom deterioration between the groups was found at the posttreatment assessment and follow-up 2. Incidence rates for MDD onset within 12 months were lower in the IG (19%) than in the CG (26%). Higher initial DSS and older age were identified as moderators of intervention effect on DSS. <b><i>Conclusions:</i></b> Our findings provide evidence for Internet-based interventions to be a suitable low-threshold intervention to treat individuals with sD and to reduce the incidence of MDD. This might be particularly true for older people with a substantial symptom burden.
DOI: 10.6084/m9.figshare.12489752
title: Supplementary Material for: Docetaxel-Induced Peripheral Neuropathy in Breast Cancer Patients Treated with Adjuvant or Neo-Adjuvant Chemotherapy

description: <b><i>Background:</i></b> Docetaxel-induced peripheral neuropathy (PN) is typically manifested as sensory and motor neuropathy. This study aimed to investigate the incidence, duration, and risk factors of sensory and motor PN and their impact on health-related quality of life (HRQOL) among breast cancer (BC) patients during the first year since starting docetaxel-based chemotherapy. <b><i>Methods:</i></b> We reported a secondary analysis of longitudinal data on docetaxel-induced PN and HRQOL among 127 BC patients. <b><i>Results:</i></b> Cumulative incidence rates of motor and sensory PN were 31.5 and 21.3%, while the median durations of motor and sensory PN were 6 and 13 weeks. A consistently significant risk factor for both PNs was a cumulative docetaxel dose of &gt;300 mg/m<sup>2</sup>. A significant interaction between sensory PN and time was found for physical and social functioning, while a significant motor PN and time interaction effect was identified for physical functioning only. <b><i>Conclusions:</i></b> Motor PN was more common than sensory PN in BC patients treated with docetaxel. Both types of PN had a significant impact on physical functioning.
DOI: 10.6084/m9.figshare.12489824.v1
title: Supplementary Material for: Adjustment of Stent Retriever Length to Clot Extent Affects First-Pass Reperfusion in Endovascular Treatment of Acute Ischemic Stroke

description: <b><i>Background:</i></b> Stent retriever technology has evolved, and significantly longer devices have become available for mechanical thrombectomy (MT) of large cerebral vessel occlusions in ischemic stroke. We hypothesized that increased stent retriever length may improve the rate of complete angiographic reperfusion and decrease the respective number of attempts, resulting in a better clinical outcome. <b><i>Methods:</i></b> Retrospective analysis of patients with large vessel occlusion in the anterior and posterior circulation treated with stent retriever MT. The study group was dichotomized into short (20 mm) and long (&gt;20 mm) retrievers using propensity matching. In the anterior circulation, the clot burden score was evaluated. Primary end points were first-pass modified thrombolysis in cerebral infarction (mTICI) 3 reperfusion and first-pass mTICI ≥ 2b reperfusion, and the secondary end point was functional independence (defined as modified Rankin Scale score 0–2) at discharge and 90 days. <b><i>Results:</i></b> Overall, 394 patients were included in the analysis. In the anterior circulation, short stent retrievers had a significantly higher rate of first-pass reperfusion in cases with low clot burden (mTICI 3: 27% vs. 17%; <i>p</i> = 0.009; mTICI ≥ 2b: 42 vs. 30%; <i>p</i> = 0.005) and in middle cerebral artery occlusions (mTICI ≥ 2b: 51 vs. 41%; <i>p</i> = 0.024). Higher rates of favorable outcome at discharge and 90 days were observed for the short stent retriever group (<i>p</i> &lt; 0.001). <b><i>Conclusion:</i></b> Stent retriever length should be adjusted to clot burden score and vessel occlusion site.
DOI: 10.6084/m9.figshare.12489743
title: Multiple sequence alignment for identification of positive selection

description: Multiple sequence alignment of genes used for identification of positive diversifying selection
DOI: 10.6084/m9.figshare.12489701
title: Metadata

description: The global rate of ICU admission, the prevalence of mortality, comorbidities, complication, number of cases demanding mechanical ventilator, length of stay and independent risk factors for ICU mortality are very important variables to be determined to reduce patient mortality and morbidity through varies mitigating strategies including but not limited to increasing number of ICU beds, mechanical ventilator, skilled professionals, integrated monitors and reducing possible risk factors
DOI: 10.6084/m9.figshare.12489701.v1
title: Metadata

description: The global rate of ICU admission, the prevalence of mortality, comorbidities, complication, number of cases demanding mechanical ventilator, length of stay and independent risk factors for ICU mortality are very important variables to be determined to reduce patient mortality and morbidity through varies mitigating strategies including but not limited to increasing number of ICU beds, mechanical ventilator, skilled professionals, integrated monitors and reducing possible risk factors
DOI: 10.6084/m9.figshare.12489518
title: ProjecTILs murine reference atlas of virus-specific CD8 T cells, version 1

description: We have developed ProjecTILs, a computational approach to project new data sets into a reference map of T cells, enabling their direct comparison in a stable, annotated system of coordinates. Because new cells are embedded in the same space of the reference, ProjecTILs enables the classification of query cells into annotated, discrete states, but also over a continuous space of intermediate states. By comparing multiple samples over the same map, and across alternative embeddings, the method allows exploring the effect of cellular perturbations (e.g. as the result of therapy or genetic engineering) and identifying genetic programs significantly altered in the query compared to a control set or to the reference map.<br>We illustrate the projection of several data sets from recent publications over two cross-study murine T cell reference atlases: the first describing tumor-infiltrating T lymphocytes (TILs), the second characterizing acute and chronic viral infection.<br>Single-cell data to build the virus-specific CD8 T cell reference map were downloaded from GEO under the following entries: GSE131535, GSE134139 and GSE119943, selecting only samples in wild type conditions. Data for the Ptpn2-KO, Tox-KO and CD4-depletion projections were obtained from entries GSE134139, GSE119943, and GSE137007 and were not included in the construction of the reference map.<br>To construct the LCMV reference map, we split the dataset into five batches that displayed strong batch effects, and applied STACAS (https://github.com/carmonalab/STACAS) to mitigate its confounding effects. We computed 800 variable genes per batch, excluding cell cycling genes, ribosomal and mitochondrial genes, and computed pairwise anchors using 200 integration genes, and otherwise default STACAS parameters. Anchors were filtered at the default threshold 0.8 percentile, and integration was performed with the IntegrateData Seurat3 function with the guide tree suggested by STACAS.<br>Next, we performed unsupervised clustering of the integrated cell embeddings using the Shared Nearest Neighbor (SNN) clustering method implemented in Seurat 3 with parameters {resolution=0.4, reduction=”pca”, k.param=20}. We then manually annotated individual clusters (merging clusters when necessary) based on several criteria: i) average expression of key marker genes in individual clusters; ii) gradients of gene expression over the UMAP representation of the reference map; iii) gene-set enrichment analysis to determine over- and under- expressed genes per cluster using MAST. In order to have access to predictive methods for UMAP, we recomputed PCA and UMAP embeddings independently of Seurat3 using respectively the prcomp function from basic R package “stats”, and the “umap” R package (https://github.com/tkonopka/umap).<br>
DOI: 10.6084/m9.figshare.12489302
title: Resultados de Análisis de abundancia diferencial de genes y rutas predichas por PICRUST2.

description: Reusltados del analisis de abundancia diferencial entre casos y controles de los genes y rutas predichas mediante PICRUST2 para cada tejido muestreado (heces, saliva, faringe y duodeno)
DOI: 10.6084/m9.figshare.12489314
title: Resultados de inferencia del potencial metabólico del microbioma con PCRUST2

description: - Contiene los resultados obtenidos por PICRUST2 de los genes (identificados por Kegg Orthology Terms) y rutas metabólicas (identificadas con METACYT IDs) para cada tejido analizado.
DOI: 10.6084/m9.figshare.12489314.v1
title: Resultados de inferencia del potencial metabólico del microbioma con PCRUST2

description: - Contiene los resultados obtenidos por PICRUST2 de los genes (identificados por Kegg Orthology Terms) y rutas metabólicas (identificadas con METACYT IDs) para cada tejido analizado.
DOI: 10.6084/m9.figshare.12489293
title: COVID19FN_Dataset.csv

description: COVID19FN is a dataset that comprises of labelled news articles of misinformation spread during the Infodemic. It contains approximately 2800 news articles, real and fake, scraped from Poynter and other fact-checking sites. It also contains information such as source URL, publish date and origin country of the news article. Potential applications of this dataset would be to explore various research areas such as classification of intention, study of spatial and temporal features, and linguistic indications that can provide further insight and help mitigate its effect as much as possible.<br>
DOI: 10.6084/m9.figshare.12489302.v2
title: Resultados de Análisis de abundancia diferencial de genes y rutas predichas por PICRUST2.

description: Reusltados del analisis de abundancia diferencial entre casos y controles de los genes y rutas predichas mediante PICRUST2 para cada tejido muestreado (heces, saliva, faringe y duodeno)
DOI: 10.6084/m9.figshare.12489269
title: Resultados de análisis de correlación de Spearman-Rank para genes y rutas metabólicas.

description: Resultdos del análisis de correlación entre los genes y rutas metabólicas predichos por PICRUST dos y la EC para cada tejido (duodeno, saliva, heces y faringe)
DOI: 10.6084/m9.figshare.12489302.v1
title: Resultados de Análisis de abundancia diferencial de genes y rutas predichas por PICRUST2.

description: Reusltados del analisis de abundancia diferencial entre casos y controles de los genes y rutas predichas mediante PICRUST2 para cada tejido muestreado (heces, saliva, faringe y duodeno)
DOI: 10.6084/m9.figshare.12489269.v2
title: Resultados de análisis de correlación de Spearman-Rank para genes y rutas metabólicas.

description: Resultdos del análisis de correlación entre los genes y rutas metabólicas predichos por PICRUST dos y la EC para cada tejido (duodeno, saliva, heces y faringe)
DOI: 10.6084/m9.figshare.12489269.v1
title: Resultados de análisis de correlación de Spearman-Rank para genes y rutas metabólicas.

description: Resultdos del análisis de correlación entre los genes y rutas metabólicas predichos por PICRUST dos y la EC para cada tejido (duodeno, saliva, heces y faringe)
DOI: 10.6084/m9.figshare.12489161
title: Supplementary Material for: New-Onset Refractory Status Epilepticus-Related Claustral Hyperintensities

description: Medicine
DOI: 10.6084/m9.figshare.12489161.v1
title: Supplementary Material for: New-Onset Refractory Status Epilepticus-Related Claustral Hyperintensities

description: Medicine
DOI: 10.5522/04/12489137
title: Dataset for: An Aegean history and archaeology written through radiocarbon dates

description: This dataset comprises a set of radiocarbon dates collected for the INSTAP-funded project “An Aegean Prehistory Written in Radiocarbon Dates”. It includes dates ranging from the Palaeolithic to the recent past and offers the largest collection so far of archaeological site and radiocarbon data from Greece (from 353 sites, totalling 3159 radiocarbon samples).
DOI: 10.5522/04/12489140
title: Supplementary Table 1

description: Dermatological signs lead to discovery of mosaic <i>ACTB</i> variants in segmental odonto-maxillary dysplasia<br><b>Supplementary Table 1</b>Phenotypic and genotypic features of patients with clinical Segmental Odontomaxillary Dysplasia and <i>ACTB</i> mosaicism.
DOI: 10.5522/04/12489137.v1
title: Dataset for: An Aegean history and archaeology written through radiocarbon dates

description: This dataset comprises a set of radiocarbon dates collected for the INSTAP-funded project “An Aegean Prehistory Written in Radiocarbon Dates”. It includes dates ranging from the Palaeolithic to the recent past and offers the largest collection so far of archaeological site and radiocarbon data from Greece (from 353 sites, totalling 3159 radiocarbon samples).
DOI: 10.5522/04/12489140.v1
title: Supplementary Table 1

description: Dermatological signs lead to discovery of mosaic <i>ACTB</i> variants in segmental odonto-maxillary dysplasia<br><b>Supplementary Table 1</b>Phenotypic and genotypic features of patients with clinical Segmental Odontomaxillary Dysplasia and <i>ACTB</i> mosaicism.