cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.30477674
title: Supplementary Material for: Cardiac troponin I for early detection of cancer therapy–related cardiac dysfunction after chemotherapy: a diagnostic test accuracy meta-analysis.

description: Introduction
Early myocardial injury during chemotherapy may precede declines in left ventricular ejection fraction (LVEF). We assessed the diagnostic accuracy of cardiac troponin I (cTnI) for early detection of cancer therapy–related cardiac dysfunction (CTRCD).
Methods
We conducted a diagnostic test-accuracy meta-analysis of prospective cohorts measuring cTnI within 3 months after chemotherapy initiation following PRISMA-DTA. Searches were conducted across PubMed, Embase, Cochrane Library, CNKI, and Wanfang databases through August 2025. A bivariate random-effects hierarchical summary receiver operating characteristic (HSROC) model estimated pooled sensitivity and specificity with confidence/prediction regions; risk of bias was appraised using QUADAS-2. Clinical implications were illustrated with Fagan nomograms at prespecified pre-test probabilities (10% and 20%).
Results
A total of 5 prospective cohort studies were included. The HSROC summary operating point yielded pooled sensitivity 0.669 (95% CI 0.444–0.836) and specificity 0.839 (95% CI 0.634–0.940). The corresponding positive likelihood ratio was 4.15 and negative was 0.39. At a 10% pre-test probability, post-test probabilities were 32% after a positive result and 4% after a negative result; at a 20% pre-test probability, they were 51% and 9%, respectively. Leave-one-out analyses indicated stable estimates.
Conclusions
Within the first 3 months of chemotherapy, cTnI shows moderate sensitivity and high specificity for early CTRCD detection. These performance characteristics support cTnI as a confirmatory biomarker to inform risk-stratified surveillance alongside imaging under standardized assay procedures.
DOI: 10.6084/m9.figshare.30477674.v1
title: Supplementary Material for: Cardiac troponin I for early detection of cancer therapy–related cardiac dysfunction after chemotherapy: a diagnostic test accuracy meta-analysis.

description: Introduction
Early myocardial injury during chemotherapy may precede declines in left ventricular ejection fraction (LVEF). We assessed the diagnostic accuracy of cardiac troponin I (cTnI) for early detection of cancer therapy–related cardiac dysfunction (CTRCD).
Methods
We conducted a diagnostic test-accuracy meta-analysis of prospective cohorts measuring cTnI within 3 months after chemotherapy initiation following PRISMA-DTA. Searches were conducted across PubMed, Embase, Cochrane Library, CNKI, and Wanfang databases through August 2025. A bivariate random-effects hierarchical summary receiver operating characteristic (HSROC) model estimated pooled sensitivity and specificity with confidence/prediction regions; risk of bias was appraised using QUADAS-2. Clinical implications were illustrated with Fagan nomograms at prespecified pre-test probabilities (10% and 20%).
Results
A total of 5 prospective cohort studies were included. The HSROC summary operating point yielded pooled sensitivity 0.669 (95% CI 0.444–0.836) and specificity 0.839 (95% CI 0.634–0.940). The corresponding positive likelihood ratio was 4.15 and negative was 0.39. At a 10% pre-test probability, post-test probabilities were 32% after a positive result and 4% after a negative result; at a 20% pre-test probability, they were 51% and 9%, respectively. Leave-one-out analyses indicated stable estimates.
Conclusions
Within the first 3 months of chemotherapy, cTnI shows moderate sensitivity and high specificity for early CTRCD detection. These performance characteristics support cTnI as a confirmatory biomarker to inform risk-stratified surveillance alongside imaging under standardized assay procedures.
DOI: 10.6084/m9.figshare.30477677
title: Supplementary Material for: A Novel Synonymous Homozygous c.2904G&gt;A Mutation in the MYO7A Gene Associated with Severe Deafness and Myopia Syndrome： A Case Report in a Chinese Family

description: Introduction
Deafness and myopia syndrome is a rare hereditary disease caused by gene mutations. Here, we present a boy with early-onset bilateral profound sensorineural hearing loss and high myopia, which is associated with a homozygous MYO7A c.2904G&gt;A variant. 
Case presentation
The proband is a boy without a family history of hereditary disease who was diagnosed with bilateral moderate to severe hearing impairment (threshold of 110db) when he was 18 months old. He was later diagnosed as having myopia at the age of 3 years 2 months with 600 degrees (-6 DS in both eyes). Genetic studies found heterozygous c.270delA (p.Asp91Ilefs*10) and c.1627G&gt;A (p.Gly543Arg) mutations in TRPM1, heterozygous c.404C&gt;T (p.Ser135Leu) variant in SLC39A5, and the homozygous c.2904G&gt;A (p.Glu968Glu) variant in MYO7A. The TRPM1 and SLC39A5 mutations were from his father, while the c.2904G&gt;A mutation in MYO7A was inherited from both parents. Advanced Bionics CI model 90k1j (processor Naida Q30) bilateral cochlear implantation was carried out. The postoperative results were good, and the proband is currently in a mainstream elementary school with normal ophthalmic follow-up, which does not show retinal abnormalities.
Conclusion
The MYO7A c.2904G&gt;A variant is probably linked with the deafness and myopia syndrome presented by the proband, and it is inherited in an autosomal recessive pattern. These findings underscore the importance of early clinical intervention, comprehensive phenotyping, and genetic testing in diagnosing rare sensory disorders, even in the absence of a family history.
DOI: 10.6084/m9.figshare.30477677.v1
title: Supplementary Material for: A Novel Synonymous Homozygous c.2904G&gt;A Mutation in the MYO7A Gene Associated with Severe Deafness and Myopia Syndrome： A Case Report in a Chinese Family

description: Introduction
Deafness and myopia syndrome is a rare hereditary disease caused by gene mutations. Here, we present a boy with early-onset bilateral profound sensorineural hearing loss and high myopia, which is associated with a homozygous MYO7A c.2904G&gt;A variant. 
Case presentation
The proband is a boy without a family history of hereditary disease who was diagnosed with bilateral moderate to severe hearing impairment (threshold of 110db) when he was 18 months old. He was later diagnosed as having myopia at the age of 3 years 2 months with 600 degrees (-6 DS in both eyes). Genetic studies found heterozygous c.270delA (p.Asp91Ilefs*10) and c.1627G&gt;A (p.Gly543Arg) mutations in TRPM1, heterozygous c.404C&gt;T (p.Ser135Leu) variant in SLC39A5, and the homozygous c.2904G&gt;A (p.Glu968Glu) variant in MYO7A. The TRPM1 and SLC39A5 mutations were from his father, while the c.2904G&gt;A mutation in MYO7A was inherited from both parents. Advanced Bionics CI model 90k1j (processor Naida Q30) bilateral cochlear implantation was carried out. The postoperative results were good, and the proband is currently in a mainstream elementary school with normal ophthalmic follow-up, which does not show retinal abnormalities.
Conclusion
The MYO7A c.2904G&gt;A variant is probably linked with the deafness and myopia syndrome presented by the proband, and it is inherited in an autosomal recessive pattern. These findings underscore the importance of early clinical intervention, comprehensive phenotyping, and genetic testing in diagnosing rare sensory disorders, even in the absence of a family history.
DOI: 10.6084/m9.figshare.30477680
title: Supplementary Material for: The importance of existential questions in patients with a depressive disorder - a pilot study

description: Background: Depressive disorders are among the most common mental illnesses. Many approaches to treatment using psychotherapy or psychotropic drugs exist, but the proportion of non-responders should not be ignored. The consideration of existential, so-called ‘meaningful questions’ of life, although their significance is well known, has so far been used little or not at all in the diagnosis and treatment of mental illnesses like depressive disorders. The aim of this study was therefore to examine the significance of existential questions in the context of depressive disorders and to shed light on the attitudes of affected patients. Method: This exploratory cross-sectional study used semi-structured interviews and questionnaires to examine 30 inpatients with a diagnosed depression and 30 mentally healthy individuals as a comparison group. Clinical parameters were collected from all study participants. The psychometrics included the recording of depression (BDI-II), anxiety (STAI-I/II), loneliness (UCLA Loneliness Scale), and life meaning (LeBe/SoMe). The BOFRETTA scale was also used to assess the subjects' fear of death and attitudes toward death. The Bochum Questionnaire on the Importance of Existential Questions (BOFBEX), newly designed for this study, was used to assess attitudes to existential issues. Results: For the depressed patients, there were unfavourable and significantly different values compared to the mentally healthy subjects years with regard to meaningfulness, and crisis of meaning. Most depressives (66.7%) stated they suffered subjectively from experience of meaninglessness at most, whereas this did not occur in any of the healthy subjects. However, the level of depressiveness correlated significantly positively with loneliness in both groups and with the perception of a crisis in meaning. Conclusions: Depressed patients had a need and desire to be able to address existential questions, which mainly concerned their loneliness, the feeling of autonomy, and having meaning in life, more strongly and more frequently with reference therapists as part of psychiatric-psychotherapeutic treatment.
DOI: 10.6084/m9.figshare.30477680.v1
title: Supplementary Material for: The importance of existential questions in patients with a depressive disorder - a pilot study

description: Background: Depressive disorders are among the most common mental illnesses. Many approaches to treatment using psychotherapy or psychotropic drugs exist, but the proportion of non-responders should not be ignored. The consideration of existential, so-called ‘meaningful questions’ of life, although their significance is well known, has so far been used little or not at all in the diagnosis and treatment of mental illnesses like depressive disorders. The aim of this study was therefore to examine the significance of existential questions in the context of depressive disorders and to shed light on the attitudes of affected patients. Method: This exploratory cross-sectional study used semi-structured interviews and questionnaires to examine 30 inpatients with a diagnosed depression and 30 mentally healthy individuals as a comparison group. Clinical parameters were collected from all study participants. The psychometrics included the recording of depression (BDI-II), anxiety (STAI-I/II), loneliness (UCLA Loneliness Scale), and life meaning (LeBe/SoMe). The BOFRETTA scale was also used to assess the subjects' fear of death and attitudes toward death. The Bochum Questionnaire on the Importance of Existential Questions (BOFBEX), newly designed for this study, was used to assess attitudes to existential issues. Results: For the depressed patients, there were unfavourable and significantly different values compared to the mentally healthy subjects years with regard to meaningfulness, and crisis of meaning. Most depressives (66.7%) stated they suffered subjectively from experience of meaninglessness at most, whereas this did not occur in any of the healthy subjects. However, the level of depressiveness correlated significantly positively with loneliness in both groups and with the perception of a crisis in meaning. Conclusions: Depressed patients had a need and desire to be able to address existential questions, which mainly concerned their loneliness, the feeling of autonomy, and having meaning in life, more strongly and more frequently with reference therapists as part of psychiatric-psychotherapeutic treatment.
DOI: 10.6084/m9.figshare.30477683
title: Supplementary Material for: A Case of Chemoradiotherapy with Interstitial Brachytherapy for the Definitive Treatment of Early-Stage Vaginal Carcinosarcoma in a Young Adult Patient: Achieving Disease Control While Maintaining Sexual Function and Quality of Life

description: Introduction: Primary vaginal carcinosarcoma is extremely rare, with only 12 cases reported to date. A consensus has not been reached on the best treatment approach, as most patients undergo surgery; however, the disease is highly refractory.
Case Presentation: We present the case of a 34-year-old woman diagnosed with vaginal carcinosarcoma after experiencing vaginal pain and bleeding. She opted for organ preservation and underwent definitive chemoradiotherapy (dCRT) using interstitial brachytherapy, receiving an initial concurrent chemoradiotherapy dose of 50 Gy in 25 fractions with weekly cisplatin. This treatment was followed by brachytherapy, in which 22.5 Gy was delivered in three fractions. To prevent vaginal stenosis, the patient was advised to undergo regular vaginal irrigation and to engage in sexual activity. At 25 months after treatment, the patient remained disease-free. The patient reported minimal impact on sexual activity, and her quality of life (QoL) was well maintained.
Conclusion: To our knowledge, this is the first reported case of early-stage vaginal carcinosarcoma treated with dCRT. This suggests a promising treatment option for preserving organs. The prevention of vaginal stenosis following dCRT, in addition to organ conservation, is essential for preserving sexual function and QoL.
DOI: 10.6084/m9.figshare.30477683.v1
title: Supplementary Material for: A Case of Chemoradiotherapy with Interstitial Brachytherapy for the Definitive Treatment of Early-Stage Vaginal Carcinosarcoma in a Young Adult Patient: Achieving Disease Control While Maintaining Sexual Function and Quality of Life

description: Introduction: Primary vaginal carcinosarcoma is extremely rare, with only 12 cases reported to date. A consensus has not been reached on the best treatment approach, as most patients undergo surgery; however, the disease is highly refractory.
Case Presentation: We present the case of a 34-year-old woman diagnosed with vaginal carcinosarcoma after experiencing vaginal pain and bleeding. She opted for organ preservation and underwent definitive chemoradiotherapy (dCRT) using interstitial brachytherapy, receiving an initial concurrent chemoradiotherapy dose of 50 Gy in 25 fractions with weekly cisplatin. This treatment was followed by brachytherapy, in which 22.5 Gy was delivered in three fractions. To prevent vaginal stenosis, the patient was advised to undergo regular vaginal irrigation and to engage in sexual activity. At 25 months after treatment, the patient remained disease-free. The patient reported minimal impact on sexual activity, and her quality of life (QoL) was well maintained.
Conclusion: To our knowledge, this is the first reported case of early-stage vaginal carcinosarcoma treated with dCRT. This suggests a promising treatment option for preserving organs. The prevention of vaginal stenosis following dCRT, in addition to organ conservation, is essential for preserving sexual function and QoL.
DOI: 10.15468/dl.6pak98
title: Occurrence Download

description: A dataset containing 291 species occurrences available in GBIF matching the query:
{
 "DatasetKey" : [
 "is Sciuridae"
 ]
}

 The dataset includes 291 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0006154-251025141854904/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.4kraes
title: Occurrence Download

description: A dataset containing 1540 species occurrences available in GBIF matching the query:
{
 "and" : [
 "BasisOfRecord is Human Observation",
 "DatasetKey is iNaturalist Research-grade Observations",
 "Geometry POLYGON((24.44169 36.84406,24.33528 36.80579,24.28207 36.68537,24.36235 36.57522,24.56118 36.57522,24.72266 36.67884,24.75627 36.79365,24.63212 36.9122,24.49677 36.8674,24.44169 36.84406))",
 "OccurrenceStatus is Present"
 ]
}

 The dataset includes 1540 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0006155-251025141854904/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.6084/m9.figshare.30477626
title: <b>Code and data for reproducing accuracy statistics charts</b> and <b>complete documentation</b>

description: <b>Code and data for reproducing accuracy statistics charts</b> and <b>complete documentation</b>
DOI: 10.6084/m9.figshare.30477626.v1
title: <b>Code and data for reproducing accuracy statistics charts</b> and <b>complete documentation</b>

description: <b>Code and data for reproducing accuracy statistics charts</b> and <b>complete documentation</b>
DOI: 10.15468/dl.9vwuvg
title: Occurrence Download

description: A dataset containing 1265 species occurrences available in GBIF matching the query:
{
 "and" : [
 "BasisOfRecord is Human Observation",
 "DatasetKey is iNaturalist Research-grade Observations",
 "Geometry POLYGON((22.87047 36.38001,22.86297 36.1974,22.91675 36.05358,23.04432 35.94351,23.21566 35.81344,23.40952 35.77842,23.39826 35.93101,23.26819 36.0961,23.1844 36.22742,23.07434 36.33623,22.97428 36.41127,22.90674 36.41377,22.87047 36.38001))",
 "OccurrenceStatus is Present"
 ]
}

 The dataset includes 1265 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0006156-251025141854904/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.5281/zenodo.17472610
title: Коэффициенты абсолютной и текущей ликвидности предприятий-банкротов ТЭК в Тюменской области
DOI: 10.5281/zenodo.17472609
title: Коэффициенты абсолютной и текущей ликвидности предприятий-банкротов ТЭК в Тюменской области
DOI: 10.5281/zenodo.17472243
title: Assessing ChatGPT adoption in higher education: an empirical analysis

description: Manuscript title is "Assessing ChatGPT adoption in higher education: an empirical analysis"

The processed data used to generate key figures, tables, and the statistical analysis in the manuscript can be found in the file named DATA_manuscript.sav. This file contains the dataset and includes variable definitions. It can be opened using IBM SPSS Statistics.

The archive also contains a file named Structural_model_manuscript.amw. This file contains the structural model that was constructed using IBM SPSS Amos.

All the data presented in the manuscript can be verified by using these two files.

We also included the images presented in the article.
DOI: 10.5281/zenodo.17472244
title: Assessing ChatGPT adoption in higher education: an empirical analysis

description: Manuscript title is "Assessing ChatGPT adoption in higher education: an empirical analysis"

The processed data used to generate key figures, tables, and the statistical analysis in the manuscript can be found in the file named DATA_manuscript.sav. This file contains the dataset and includes variable definitions. It can be opened using IBM SPSS Statistics.

The archive also contains a file named Structural_model_manuscript.amw. This file contains the structural model that was constructed using IBM SPSS Amos.

All the data presented in the manuscript can be verified by using these two files.

We also included the images presented in the article.
DOI: 10.15468/dl.vjjynh
title: Occurrence Download

description: A dataset containing 18613 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Abies grandis",
 "HasCoordinate is true",
 "HasGeospatialIssue is false"
 ]
}

 The dataset includes 18613 records from 290 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0006157-251025141854904/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.5281/zenodo.17472593
title: Data to accompany "Intensified Diurnal Cycle of Convection Explains Nearly Half of Tropical High-Cloud Feedback" by Deutloff et al., 2025

description: This repository contains the data to reproduce the figures and numbers from Deutloff et al., 2025.
DOI: 10.5281/zenodo.17472594
title: Data to accompany "Intensified Diurnal Cycle of Convection Explains Nearly Half of Tropical High-Cloud Feedback" by Deutloff et al., 2025

description: This repository contains the data to reproduce the figures and numbers from Deutloff et al., 2025.
DOI: 10.25549/usctheses-ouc11399m5uj
title: ORGANIZING SMALL RNA PATHWAYS THROUGH BIOMOLECULAR CONDENSATES A Molecular Dissection of SIMR Foci in C. Elegans
DOI: 10.25549/usctheses-ouc11399m5ul
title: Multi-timescale Stochastic Programming with Applications in Power Systems
DOI: 10.25549/usctheses-ouc11399m5uk
title: Enhancing Visual and Haptic Feedback in Extended Reality(XR) using Quadcopters
DOI: 10.15468/dl.bf3gvn
title: Occurrence Download

description: A dataset containing 56 species occurrences available in GBIF matching the query:
{
 "and" : [
 "BasisOfRecord is Human Observation",
 "DatasetKey is iNaturalist Research-grade Observations",
 "Geometry POLYGON((26.91582 35.48011,26.78593 35.46269,26.79465 35.33438,27.04571 35.25122,27.11778 35.34864,27.0362 35.45873,26.94433 35.48011,26.91582 35.48011))",
 "OccurrenceStatus is Present"
 ]
}

 The dataset includes 56 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0006158-251025141854904/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.5281/zenodo.17472572
title: Коэффициенты абсолютной и текущей ликвидности действующих предприятий ТЭК в Тюменской области
DOI: 10.5281/zenodo.17472571
title: Коэффициенты абсолютной и текущей ликвидности действующих предприятий ТЭК в Тюменской области
DOI: 10.25345/c5td9nn4t
title: MassIVE MSV000099682 - Shake and bake: a robust and cost-effective sample preparation recipe for plasma and cerebrospinal fluid
title: Background Plasma and cerebrospinal fluid CSF are complementary sources of biomarkers for neurodegenerative diseases. However, the wide dynamic range of protein abundances, particularly in plasma, hinders detection of low-abundance proteins. Depletion of high-abundance proteins and efficient enzymatic digestion can improve proteome coverage but must be carefully optimized for reproducibility, throughput, and cost-efficiency in large-scale clinical studies. Results We developed a scalable sample preparation workflow for plasma and CSF that integrates high-abundance protein depletion, optimized digestion using Lys-C and trypsin, and compatibility with both label-free and TMT-based quantification. We systematically evaluated depletion efficiency, mixing speed, enzyme digestion strategy, and the use of sodium deoxycholate, monitoring the number of detectable proteins and quantitative precision. A resin to plasma ratio of more than 75 and a mixing speed of 900 rpm ensured complete and reproducible depletion. Depletion increased protein group identifications by about 80percent in plasma and 65percent in CSF, while maintaining quantitative precision median coefficient of variation CV less than 11 percent. A two-step digestion protocol using Lys-C trypsin followed by trypsin yielded the highest reproducibility. DOC marginally improved proteome coverage but reduced quantification precision and throughput. In depleted plasma, detection of brain-enriched proteins tripled compared to non-depleted plasma. Technical replicates from a 528-sample clinical ALS cohort showed high reproducibility, with intra-sample CVs substantially lower than inter-individual variation. Conclusions This depletion-based sample preparation workflow enables deep and reproducible proteome profiling of plasma and CSF in high-throughput formats and is well suited for biomarker discovery in large clinical studies.