cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.5281/zenodo.13938287
title: Molecular Probes for Tracking Lipid Droplet Membrane Dynamics

description: Abstract

Lipid droplets (LDs) and their membrane proteins play crucial roles in lipid metabolism, signaling, and information transport within cells. LDs feature a unique monolayer lipid membrane that has not been extensively studied due to the lack of suitable molecular probes that are able to distinguish this membrane from the LD lipid core. In this work, we present a three-pronged molecular probe design strategy that combines lipophilicity-based organelle targeting with microenvironment-dependent activation. As a proof-of-concept, we designed an LD membrane labeling pro-probe called LDM, which selectively localizes around LD membranes. Upon activation by the HClO/ClO− microenvironment that surrounds LDs, LDM pro-probe undergoes a color change and releases LDM-OH probe that binds to LD membrane proteins. This localizes the probe to the LD-associated protein space which is restricted to the membrane thus enabling visualization of the ring-like LD membrane. By utilizing LDM, we identified the dynamic mechanism of LD membrane contacts and their protein accumulation parameters. Furthermore, using LDM in liver cancer cells allowed us to examine the changes in LD/mitochondrial protein accumulation caused by the state of starvation these cells encounter. This led to the discovery that liver cancer cells respond to energy stress during hunger by enhancing LD-mitochondria interactions. Taken together, LDM represents the first molecular probe for imaging LD membranes in live cells, and represents an attractive tool for further investigations into the specific regulatory mechanisms and drug discovery associated with LD related metabolism diseases.

 

Keywords: Molecular Imaging, Cancer, Lipid droplets, Super-resolution Imaging
DOI: 10.15468/dl.5gmkg9
title: Occurrence Download

description: A dataset containing 54742 species occurrences available in GBIF matching the query:
{
 "and" : [
 {
 "and" : [
 "HasGeospatialIssue is false",
 "HasCoordinate is true",
 "OccurrenceStatus is Present",
 {
 "not" : {
 "BasisOfRecord" : [
 "is one of (Fossil, Living Specimen)"
 ]
 }
 }
 ]
 },
 "TaxonKey is Hipparchia semele Linnaeus, 1758",
 "PhylumKey is Arthropoda",
 "Year is greater than or equal to 1992",
 "Year is less than or equal to 2012",
 "Geometry POLYGON((-26 34, 42 34, 42 70, -26 70, -26 34))"
 ]
}

 The dataset includes 54742 records from 333 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0016845-241007104925546/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.57841/casdc.0003979
title: 地史时期海陆生物多样性与古地理古气候重建数据集
DOI: 10.57841/casdc.0003980
title: 泥盆纪古海洋生物事件、缺氧事件与古气候变化数据集
DOI: 10.57841/casdc.0003981
title: KGB金钉子提案
DOI: 10.15468/dl.665byb
title: Occurrence Download

description: A dataset containing 38042 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Nicandra physalodes (L.) Gaertn.",
 "OccurrenceStatus is Present",
 "Country is not null",
 "Year is not null"
 ]
}

 The dataset includes 38042 records from 517 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0016846-241007104925546/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.5281/zenodo.11577148
title: Trento 1936 - Building 918

description: Coordinates: N/A Length: 14.56 mWidth: 10.13 mHeight: 16.45 mPoints: 12 Vertices: 60 Primitives: 20 Main Files:
Filename.glb.xml.objbuilding_918.glbLinkbuilding_918.objLink11577148_edm.xmlLink11577148_metsmods.xmlLinkThumbnails:
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DOI: 10.5281/zenodo.11577149
title: Trento 1936 - Building 918

description: Coordinates: N/A Length: 14.56 mWidth: 10.13 mHeight: 16.45 mPoints: 12 Vertices: 60 Primitives: 20
DOI: 10.5281/zenodo.12537666
title: Trento 1911 - Building 137

description: Coordinates: N/A Length: 26.58 mWidth: 7.32 mHeight: 17.12 mPoints: 12 Vertices: 60 Primitives: 20 Main Files:
Filename.glb.objbuilding_137.glbLinkbuilding_137.objLinkThumbnails:
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DOI: 10.5281/zenodo.12538236
title: Trento 1911 - Building 1063

description: Coordinates: N/A Length: 6.69 mWidth: 13.48 mHeight: 24.96 mPoints: 8 Vertices: 36 Primitives: 12 Main Files:
Filename.glb.objbuilding_1063.objLinkbuilding_1063.glbLinkThumbnails:
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DOI: 10.5281/zenodo.12547901
title: Trento 1936 - Building 918

description: Coordinates: N/A Length: 14.56 mWidth: 10.13 mHeight: 16.45 mPoints: 12 Vertices: 60 Primitives: 20 Main Files:
Filename.glb.objbuilding_918.objLinkbuilding_918.glbLinkThumbnails:
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DOI: 10.5281/zenodo.12694139
title: Trento 1911 - Building 1063

description: Coordinates: N/A Length: 6.69 mWidth: 13.48 mHeight: 24.96 mPoints: 8 Vertices: 36 Primitives: 12 Main Files:
Filename.glb.xml.objbuilding_1063.objLinkbuilding_1063.glbLink11569641_edm.xmlLink11569641_metsmods.xmlLinkThumbnails:
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DOI: 10.5281/zenodo.12694152
title: Sion 1640 - Building 183 (LoD-1)

description: Coordinates: N/A Length: 12.95 mWidth: 13.68 mHeight: 6.45 mVertices: 24 Primitives: 12  The Length, Width, Height, Vertices and Primitives listed above have been derived directly from the OBJ file.Main Files:
Filename.mtl.glb.xml.obj0___LoD1__id-183.objLink0___LoD1__id-183.mtlLink0___LoD1__id-183.glbLink11250945_metsmods.xmlLink11250945_edm.xmlLinkThumbnails:
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DOI: 10.5281/zenodo.12694156
title: Sion 1840 - Building 66 (LoD-1)

description: Coordinates: N/A Length: 8.84 mWidth: 11.96 mHeight: 11.07 mVertices: 42 Primitives: 24  The Length, Width, Height, Vertices and Primitives listed above have been derived directly from the OBJ file.Main Files:
Filename.mtl.glb.xml.obj0___LoD1__id-66_001.mtlLink0___LoD1__id-66_001.objLink0___LoD1__id-66_001.glbLink11248822_metsmods.xmlLink11248822_edm.xmlLinkThumbnails:
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DOI: 10.5281/zenodo.12694158
title: Trento 1936 - Building 918

description: Coordinates: N/A Length: 14.56 mWidth: 10.13 mHeight: 16.45 mPoints: 12 Vertices: 60 Primitives: 20 Main Files:
Filename.glb.xml.objbuilding_918.glbLinkbuilding_918.objLink11577148_edm.xmlLink11577148_metsmods.xmlLinkThumbnails:
Perspective1000x1000512x512256x256128x128Perspective 1LinkLinkLinkLinkPerspective 2LinkLinkLinkLinkPerspective 3LinkLinkLinkLinkPerspective 4LinkLinkLinkLinkPerspective TopLinkLinkLinkLinkChangelog:   - v0.0.2: Thumbnails added, Description updated with Link Tables.  - v0.0.3: Added XMLs for Europeana Data Model (EDM) and MetsMods.
DOI: 10.5281/zenodo.11250182
title: Sion 1640 - Building 77 (LoD-1)

description: Coordinates: N/A Length: 13.36 mWidth: 10.71 mHeight: 4.68 mVertices: 42 Primitives: 24  The Length, Width, Height, Vertices and Primitives listed above have been derived directly from the OBJ file.Main Files:
Filename.mtl.glb.xml.obj0___LoD1__id-77.glbLink0___LoD1__id-77.mtlLink0___LoD1__id-77.objLink11250182_metsmods.xmlLink11250182_edm.xmlLinkThumbnails:
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DOI: 10.5281/zenodo.11250183
title: Sion 1640 - Building 77 (LoD-1)

description: Coordinates: N/A Length: 13.36 mWidth: 10.71 mHeight: 4.68 mVertices: 42 Primitives: 24  The Length, Width, Height, Vertices and Primitives listed above have been derived directly from the OBJ file.
DOI: 10.5281/zenodo.11488605
title: Sion 1640 - Building 77 (LoD-1)

description: Coordinates: N/A Length: 13.36 mWidth: 10.71 mHeight: 4.68 mVertices: 42 Primitives: 24  The Length, Width, Height, Vertices and Primitives listed above have been derived directly from the OBJ file.Main Files:
Filename.mtl.glb.obj0___LoD1__id-77.glbLink0___LoD1__id-77.objLink0___LoD1__id-77.mtlLinkThumbnails:
Perspective1000x1000512x512256x256128x128Perspective 1LinkLinkLinkLinkPerspective 2LinkLinkLinkLinkPerspective 3LinkLinkLinkLinkPerspective 4LinkLinkLinkLinkPerspective TopLinkLinkLinkLinkChangelog:   - v0.0.2: Thumbnails added, Description updated with Link Tables.
DOI: 10.5281/zenodo.11574436
title: Trento 1936 - Building 1932

description: Coordinates: N/A Length: 18.85 mWidth: 9.66 mHeight: 11.13 mPoints: 16 Vertices: 84 Primitives: 28 Main Files:
Filename.glb.xml.objbuilding_1932.objLinkbuilding_1932.glbLink11574436_edm.xmlLink11574436_metsmods.xmlLinkThumbnails:
Perspective1000x1000512x512256x256128x128Perspective 1LinkLinkLinkLinkPerspective 2LinkLinkLinkLinkPerspective 3LinkLinkLinkLinkPerspective 4LinkLinkLinkLinkPerspective TopLinkLinkLinkLinkChangelog:   - v0.0.2: Thumbnails added, Description updated with Link Tables.  - v0.0.3: Added XMLs for Europeana Data Model (EDM) and MetsMods.
DOI: 10.5281/zenodo.11574437
title: Trento 1936 - Building 1932

description: Coordinates: N/A Length: 18.85 mWidth: 9.66 mHeight: 11.13 mPoints: 16 Vertices: 84 Primitives: 28
DOI: 10.5281/zenodo.12542827
title: Trento 1936 - Building 1932

description: Coordinates: N/A Length: 18.85 mWidth: 9.66 mHeight: 11.13 mPoints: 16 Vertices: 84 Primitives: 28 Main Files:
Filename.glb.objbuilding_1932.glbLinkbuilding_1932.objLinkThumbnails:
Perspective1000x1000512x512256x256128x128Perspective 1LinkLinkLinkLinkPerspective 2LinkLinkLinkLinkPerspective 3LinkLinkLinkLinkPerspective 4LinkLinkLinkLinkPerspective TopLinkLinkLinkLinkChangelog:   - v0.0.2: Thumbnails added, Description updated with Link Tables.
DOI: 10.5281/zenodo.12694160
title: Sion 1640 - Building 77 (LoD-1)

description: Coordinates: N/A Length: 13.36 mWidth: 10.71 mHeight: 4.68 mVertices: 42 Primitives: 24  The Length, Width, Height, Vertices and Primitives listed above have been derived directly from the OBJ file.Main Files:
Filename.mtl.glb.xml.obj0___LoD1__id-77.glbLink0___LoD1__id-77.mtlLink0___LoD1__id-77.objLink11250182_metsmods.xmlLink11250182_edm.xmlLinkThumbnails:
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DOI: 10.5281/zenodo.12694163
title: Trento 1936 - Building 1932

description: Coordinates: N/A Length: 18.85 mWidth: 9.66 mHeight: 11.13 mPoints: 16 Vertices: 84 Primitives: 28 Main Files:
Filename.glb.xml.objbuilding_1932.objLinkbuilding_1932.glbLink11574436_edm.xmlLink11574436_metsmods.xmlLinkThumbnails:
Perspective1000x1000512x512256x256128x128Perspective 1LinkLinkLinkLinkPerspective 2LinkLinkLinkLinkPerspective 3LinkLinkLinkLinkPerspective 4LinkLinkLinkLinkPerspective TopLinkLinkLinkLinkChangelog:   - v0.0.2: Thumbnails added, Description updated with Link Tables.  - v0.0.3: Added XMLs for Europeana Data Model (EDM) and MetsMods.
DOI: 10.5281/zenodo.11564864
title: Trento 1851 - Building 1095

description: Coordinates: N/A Length: 17.9 mWidth: 12.0 mHeight: 7.46 mPoints: 10 Vertices: 48 Primitives: 16
DOI: 10.5281/zenodo.11569011
title: Trento 1911 - Building 1517

description: Coordinates: N/A Length: 26.43 mWidth: 16.29 mHeight: 29.28 mPoints: 22 Vertices: 120 Primitives: 40
DOI: 10.5281/zenodo.11573838
title: Trento 1936 - Building 193

description: Coordinates: N/A Length: 32.67 mWidth: 12.66 mHeight: 12.95 mPoints: 14 Vertices: 72 Primitives: 24
DOI: 10.5281/zenodo.12537669
title: Trento 1911 - Building 1517

description: Coordinates: N/A Length: 26.43 mWidth: 16.29 mHeight: 29.28 mPoints: 22 Vertices: 120 Primitives: 40 Main Files:
Filename.glb.objbuilding_1517.objLinkbuilding_1517.glbLinkThumbnails:
Perspective1000x1000512x512256x256128x128Perspective 1LinkLinkLinkLinkPerspective 2LinkLinkLinkLinkPerspective 3LinkLinkLinkLinkPerspective 4LinkLinkLinkLinkPerspective TopLinkLinkLinkLinkChangelog:   - v0.0.2: Thumbnails added, Description updated with Link Tables.
DOI: 10.5281/zenodo.11564863
title: Trento 1851 - Building 1095

description: Coordinates: N/A Length: 17.9 mWidth: 12.0 mHeight: 7.46 mPoints: 10 Vertices: 48 Primitives: 16 Main Files:
Filename.glb.xml.objbuilding_1095.glbLinkbuilding_1095.objLink11564863_edm.xmlLink11564863_metsmods.xmlLinkThumbnails:
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DOI: 10.5281/zenodo.11569010
title: Trento 1911 - Building 1517

description: Coordinates: N/A Length: 26.43 mWidth: 16.29 mHeight: 29.28 mPoints: 22 Vertices: 120 Primitives: 40 Main Files:
Filename.glb.xml.objbuilding_1517.objLinkbuilding_1517.glbLink11569010_edm.xmlLink11569010_metsmods.xmlLinkThumbnails:
Perspective1000x1000512x512256x256128x128Perspective 1LinkLinkLinkLinkPerspective 2LinkLinkLinkLinkPerspective 3LinkLinkLinkLinkPerspective 4LinkLinkLinkLinkPerspective TopLinkLinkLinkLinkChangelog:   - v0.0.2: Thumbnails added, Description updated with Link Tables.  - v0.0.3: Added XMLs for Europeana Data Model (EDM) and MetsMods.
DOI: 10.5281/zenodo.11573837
title: Trento 1936 - Building 193

description: Coordinates: N/A Length: 32.67 mWidth: 12.66 mHeight: 12.95 mPoints: 14 Vertices: 72 Primitives: 24 Main Files:
Filename.glb.xml.objbuilding_193.objLinkbuilding_193.glbLink11573837_metsmods.xmlLink11573837_edm.xmlLinkThumbnails:
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DOI: 10.5281/zenodo.12532179
title: Trento 1851 - Building 1095

description: Coordinates: N/A Length: 17.9 mWidth: 12.0 mHeight: 7.46 mPoints: 10 Vertices: 48 Primitives: 16 Main Files:
Filename.glb.objbuilding_1095.glbLinkbuilding_1095.objLinkThumbnails:
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DOI: 10.5281/zenodo.12541921
title: Trento 1936 - Building 193

description: Coordinates: N/A Length: 32.67 mWidth: 12.66 mHeight: 12.95 mPoints: 14 Vertices: 72 Primitives: 24 Main Files:
Filename.glb.objbuilding_193.glbLinkbuilding_193.objLinkThumbnails:
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DOI: 10.5281/zenodo.12694167
title: Trento 1936 - Building 193

description: Coordinates: N/A Length: 32.67 mWidth: 12.66 mHeight: 12.95 mPoints: 14 Vertices: 72 Primitives: 24 Main Files:
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DOI: 10.5281/zenodo.12694172
title: Trento 1911 - Building 1517

description: Coordinates: N/A Length: 26.43 mWidth: 16.29 mHeight: 29.28 mPoints: 22 Vertices: 120 Primitives: 40 Main Files:
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DOI: 10.5281/zenodo.12694177
title: Trento 1851 - Building 1095

description: Coordinates: N/A Length: 17.9 mWidth: 12.0 mHeight: 7.46 mPoints: 10 Vertices: 48 Primitives: 16 Main Files:
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DOI: 10.5281/zenodo.11576482
title: Trento 1936 - Building 2567

description: Coordinates: N/A Length: 8.12 mWidth: 6.21 mHeight: 11.71 mPoints: 8 Vertices: 36 Primitives: 12 Main Files:
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DOI: 10.5281/zenodo.11576483
title: Trento 1936 - Building 2567

description: Coordinates: N/A Length: 8.12 mWidth: 6.21 mHeight: 11.71 mPoints: 8 Vertices: 36 Primitives: 12
DOI: 10.5281/zenodo.12546767
title: Trento 1936 - Building 2567

description: Coordinates: N/A Length: 8.12 mWidth: 6.21 mHeight: 11.71 mPoints: 8 Vertices: 36 Primitives: 12 Main Files:
Filename.glb.objbuilding_2567.objLinkbuilding_2567.glbLinkThumbnails:
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DOI: 10.5281/zenodo.12694173
title: Trento 1936 - Building 2567

description: Coordinates: N/A Length: 8.12 mWidth: 6.21 mHeight: 11.71 mPoints: 8 Vertices: 36 Primitives: 12 Main Files:
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DOI: 10.5281/zenodo.11566365
title: Trento 1886 - Building 596

description: Coordinates: N/A Length: 19.05 mWidth: 10.0 mHeight: 21.45 mPoints: 24 Vertices: 132 Primitives: 44 Main Files:
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DOI: 10.5281/zenodo.11566366
title: Trento 1886 - Building 596

description: Coordinates: N/A Length: 19.05 mWidth: 10.0 mHeight: 21.45 mPoints: 24 Vertices: 132 Primitives: 44
DOI: 10.5281/zenodo.11570317
title: Trento 1911 - Building 1482

description: Coordinates: N/A Length: 27.63 mWidth: 15.84 mHeight: 18.88 mPoints: 20 Vertices: 108 Primitives: 36 Main Files:
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DOI: 10.5281/zenodo.11570318
title: Trento 1911 - Building 1482

description: Coordinates: N/A Length: 27.63 mWidth: 15.84 mHeight: 18.88 mPoints: 20 Vertices: 108 Primitives: 36
DOI: 10.5281/zenodo.12534486
title: Trento 1886 - Building 596

description: Coordinates: N/A Length: 19.05 mWidth: 10.0 mHeight: 21.45 mPoints: 24 Vertices: 132 Primitives: 44 Main Files:
Filename.glb.objbuilding_596.objLinkbuilding_596.glbLinkThumbnails:
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DOI: 10.5281/zenodo.12538784
title: Trento 1911 - Building 1482

description: Coordinates: N/A Length: 27.63 mWidth: 15.84 mHeight: 18.88 mPoints: 20 Vertices: 108 Primitives: 36 Main Files:
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DOI: 10.5281/zenodo.12694175
title: Trento 1886 - Building 596

description: Coordinates: N/A Length: 19.05 mWidth: 10.0 mHeight: 21.45 mPoints: 24 Vertices: 132 Primitives: 44 Main Files:
Filename.glb.xml.objbuilding_596.objLinkbuilding_596.glbLink11566365_metsmods.xmlLink11566365_edm.xmlLinkThumbnails:
Perspective1000x1000512x512256x256128x128Perspective 1LinkLinkLinkLinkPerspective 2LinkLinkLinkLinkPerspective 3LinkLinkLinkLinkPerspective 4LinkLinkLinkLinkPerspective TopLinkLinkLinkLinkChangelog:   - v0.0.2: Thumbnails added, Description updated with Link Tables.  - v0.0.3: Added XMLs for Europeana Data Model (EDM) and MetsMods.