cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.9380249
title: A lungfish survivor of the end-Devonian extinction and an Early Carboniferous dipnoan radiation

description: Until recently the immediate aftermath of the Hangenberg event of the Famennian Stage (Upper Devonian) was considered to have decimated sarcopterygian groups, including lungfish, with only two taxa, <i>Occludus romeri</i> and <i>Sagenodus</i> spp., being unequivocally recorded from rocks of Tournaisian age (Mississippian, Early Carboniferous). Recent discoveries of numerous morphologically diverse lungfish tooth plates from southern Scotland and northern England indicate that at least 10 dipnoan taxa existed during the earliest Carboniferous. Of these taxa, only two, <i>Xylognathus</i> and <i>Ballgadus</i>, preserve cranial and postcranial skeletal elements, which have yet to be described. Here we present a description of the skull of a new genus and species of lungfish, <i>Limanichthys fraseri</i> gen. et sp. nov., which hails from the very earliest Tournaisian in the Ballagan Formation of Burnmouth, southern Scotland. The new specimen represents the earliest definitive Tournaisian lungfish skull material, thus providing an invaluable insight into the response of this group – and, indeed, Sarcopterygii as a whole – immediately following the latest Devonian Hangenberg event. Phylogenetic analysis places <i>Limanichthys fraseri</i> within the Devonian ‘phaneropleurid-fleurantiid’ grade of lungfish and shows that the Carboniferous lungfish represent forms that have their origins deep in the Middle and Late Devonian as well as those from a unique Carboniferous radiation. http://zoobank.org/urn:lsid:zoobank.org:pub:101FFE43-42D5-4950-9169-A900113B6F1D
DOI: 10.6084/m9.figshare.9380249.v1
title: A lungfish survivor of the end-Devonian extinction and an Early Carboniferous dipnoan radiation

description: Until recently the immediate aftermath of the Hangenberg event of the Famennian Stage (Upper Devonian) was considered to have decimated sarcopterygian groups, including lungfish, with only two taxa, <i>Occludus romeri</i> and <i>Sagenodus</i> spp., being unequivocally recorded from rocks of Tournaisian age (Mississippian, Early Carboniferous). Recent discoveries of numerous morphologically diverse lungfish tooth plates from southern Scotland and northern England indicate that at least 10 dipnoan taxa existed during the earliest Carboniferous. Of these taxa, only two, <i>Xylognathus</i> and <i>Ballgadus</i>, preserve cranial and postcranial skeletal elements, which have yet to be described. Here we present a description of the skull of a new genus and species of lungfish, <i>Limanichthys fraseri</i> gen. et sp. nov., which hails from the very earliest Tournaisian in the Ballagan Formation of Burnmouth, southern Scotland. The new specimen represents the earliest definitive Tournaisian lungfish skull material, thus providing an invaluable insight into the response of this group – and, indeed, Sarcopterygii as a whole – immediately following the latest Devonian Hangenberg event. Phylogenetic analysis places <i>Limanichthys fraseri</i> within the Devonian ‘phaneropleurid-fleurantiid’ grade of lungfish and shows that the Carboniferous lungfish represent forms that have their origins deep in the Middle and Late Devonian as well as those from a unique Carboniferous radiation. http://zoobank.org/urn:lsid:zoobank.org:pub:101FFE43-42D5-4950-9169-A900113B6F1D
DOI: 10.6084/m9.figshare.9380345
title: Anatomy, possible sexual dimorphism, and phylogenetic affinities of a new mylodontine sloth from the late Pleistocene of intertropical Brazil

description: <i>Glossotherium phoenesis</i> sp. nov. from the late Pleistocene of intertropical Brazil is described and compared with <i>Glossotherium robustum</i> and <i>Glossotherium tropicorum</i>. Compared to these two species, the main differences occur in the shape of the nasal region and pterygoids, proportionate narrowing of the skull, length and arrangement of the tooth rows, degree of projection and form of the mandibular symphysis, height at various points along the dentary, and proportions of the radius, among others described. Clear differences in two well-preserved skulls of the new species are interpreted as representing sexual dimorphism, as occurs in other ground sloths such as <i>Paramylodon</i> and <i>Eremotherium</i>. Other notable features are described for osteoderms and for the ontogenetic developments of the mandible and dentition. The new species <i>G. phoenesis</i> appears to be one of the most derived Mylodontidae, sister taxon of <i>G. tropicorum</i>, and closely related to <i>Pleurolestodon</i>. http://zoobank.org/urn:lsid:zoobank.org:pub:3F1BAFDB-FC4A-442E-ADFD-692EB2DC7655
DOI: 10.6084/m9.figshare.9380345.v1
title: Anatomy, possible sexual dimorphism, and phylogenetic affinities of a new mylodontine sloth from the late Pleistocene of intertropical Brazil

description: <i>Glossotherium phoenesis</i> sp. nov. from the late Pleistocene of intertropical Brazil is described and compared with <i>Glossotherium robustum</i> and <i>Glossotherium tropicorum</i>. Compared to these two species, the main differences occur in the shape of the nasal region and pterygoids, proportionate narrowing of the skull, length and arrangement of the tooth rows, degree of projection and form of the mandibular symphysis, height at various points along the dentary, and proportions of the radius, among others described. Clear differences in two well-preserved skulls of the new species are interpreted as representing sexual dimorphism, as occurs in other ground sloths such as <i>Paramylodon</i> and <i>Eremotherium</i>. Other notable features are described for osteoderms and for the ontogenetic developments of the mandible and dentition. The new species <i>G. phoenesis</i> appears to be one of the most derived Mylodontidae, sister taxon of <i>G. tropicorum</i>, and closely related to <i>Pleurolestodon</i>. http://zoobank.org/urn:lsid:zoobank.org:pub:3F1BAFDB-FC4A-442E-ADFD-692EB2DC7655
DOI: 10.6084/m9.figshare.9378812
title: GRL-Supplement

description: Experiment data in the revision version
DOI: 10.6084/m9.figshare.9378812.v1
title: GRL-Supplement

description: Experiment data in the revision version
DOI: 10.6084/m9.figshare.9375971
title: New peptide derived antimalaria and antimicrobial agents bearing sulphonamide moiety

description: Fourteen novel dipeptide carboxamide derivatives bearing benzensulphonamoyl propanamide were synthesized and characterized using <sup>1</sup>H NMR, <sup>13</sup>C NMR, FTIR and MS spectroscopic techniques. <i>In vivo</i> antimalarial and <i>in vitro</i> antimicrobial studies were carried out on these synthesized compounds. Molecular docking, haematological analysis, liver and kidney function tests were also evaluated to assess the effect of the compounds on the organs. At 200 mg/kg body weight, <b>7i</b> inhibited the multiplication of the parasite by 81.38% on day 12 of post-treatment exposure. This was comparable to the 82.34% reduction with artemisinin. The minimum inhibitory concentration (MIC) in µM ranged from 0.03 to 2.34 with <b>7h</b> having MIC of 0.03 µM against <i>Plasmodium falciparium.</i> The <i>in vitro</i> antibacterial activity of the compounds against some clinically isolated bacteria strains showed varied activities with some of the new compounds showing better activities against the bacteria and the fungi more than the reference drug ciprofloxacin and fluconazole.
DOI: 10.6084/m9.figshare.9375971.v1
title: New peptide derived antimalaria and antimicrobial agents bearing sulphonamide moiety

description: Fourteen novel dipeptide carboxamide derivatives bearing benzensulphonamoyl propanamide were synthesized and characterized using <sup>1</sup>H NMR, <sup>13</sup>C NMR, FTIR and MS spectroscopic techniques. <i>In vivo</i> antimalarial and <i>in vitro</i> antimicrobial studies were carried out on these synthesized compounds. Molecular docking, haematological analysis, liver and kidney function tests were also evaluated to assess the effect of the compounds on the organs. At 200 mg/kg body weight, <b>7i</b> inhibited the multiplication of the parasite by 81.38% on day 12 of post-treatment exposure. This was comparable to the 82.34% reduction with artemisinin. The minimum inhibitory concentration (MIC) in µM ranged from 0.03 to 2.34 with <b>7h</b> having MIC of 0.03 µM against <i>Plasmodium falciparium.</i> The <i>in vitro</i> antibacterial activity of the compounds against some clinically isolated bacteria strains showed varied activities with some of the new compounds showing better activities against the bacteria and the fungi more than the reference drug ciprofloxacin and fluconazole.
DOI: 10.6084/m9.figshare.9375044
title: Supplementary Material for: Association between Aortic Calcification, Cardiovascular Events, and Mortality in Kidney and Pancreas-Kidney Transplant Recipients

description: <b><i>Background:</i></b> Cardiovascular (CV) disease is the leading cause of death in kidney and simultaneous pancreas-kidney (SPK) transplant recipients. Assessing abdominal aortic calcification (AAC), using lateral spine x-rays and the Kaupilla 24-point AAC (0–24) score, may identify transplant recipients at higher CV risk. <b><i>Methods:</i></b> Between the years 2000 and 2015, 413 kidney and 213 SPK first transplant recipients were scored for AAC at time of transplant and then followed for CV events (coronary heart, cerebrovascular, or peripheral vascular disease), graft-loss, and all-cause mortality. <b><i>Results:</i></b> The mean age was 44 ± 12 years (SD) with 275 (44%) having AAC (26% moderate: 1–7 and 18% high: ≥8). After a median of 65 months (IQR 29–107 months), 46 recipients experienced CV events, 59 died, and 80 suffered graft loss. For each point increase in AAC, the unadjusted hazard ratios (HR) for CV events and mortality were 1.11 (95% CI 1.07–1.15) and 1.11 (1.08–1.15). These were similar after adjusting for age, gender, smoking, transplant type, dialysis vintage, and diabetes: aHR 1.07 (95% CI 1.02–1.12) and 1.09 (1.04–1.13). For recipients with high versus no AAC, the unadjusted and fully-adjusted HRs for CV events were 5.90 (2.90–12.02) and 3.51 (1.54–8.00), for deaths 5.39 (3.00–9.68) and 3.38 (1.71–6.70), and for graft loss 1.30 (0.75–2.28) and 1.94 (1.04–3.27) in age and smoking history-adjusted analyses. <b><i>Conclusion:</i></b> Kidney and SPK transplant recipients with high AAC have 3-fold higher CV and mortality risk and poorer graft outcomes than recipients without AAC. AAC scoring may be useful in assessing and targeted risk-lowering strategies.
DOI: 10.6084/m9.figshare.9375044.v1
title: Supplementary Material for: Association between Aortic Calcification, Cardiovascular Events, and Mortality in Kidney and Pancreas-Kidney Transplant Recipients

description: <b><i>Background:</i></b> Cardiovascular (CV) disease is the leading cause of death in kidney and simultaneous pancreas-kidney (SPK) transplant recipients. Assessing abdominal aortic calcification (AAC), using lateral spine x-rays and the Kaupilla 24-point AAC (0–24) score, may identify transplant recipients at higher CV risk. <b><i>Methods:</i></b> Between the years 2000 and 2015, 413 kidney and 213 SPK first transplant recipients were scored for AAC at time of transplant and then followed for CV events (coronary heart, cerebrovascular, or peripheral vascular disease), graft-loss, and all-cause mortality. <b><i>Results:</i></b> The mean age was 44 ± 12 years (SD) with 275 (44%) having AAC (26% moderate: 1–7 and 18% high: ≥8). After a median of 65 months (IQR 29–107 months), 46 recipients experienced CV events, 59 died, and 80 suffered graft loss. For each point increase in AAC, the unadjusted hazard ratios (HR) for CV events and mortality were 1.11 (95% CI 1.07–1.15) and 1.11 (1.08–1.15). These were similar after adjusting for age, gender, smoking, transplant type, dialysis vintage, and diabetes: aHR 1.07 (95% CI 1.02–1.12) and 1.09 (1.04–1.13). For recipients with high versus no AAC, the unadjusted and fully-adjusted HRs for CV events were 5.90 (2.90–12.02) and 3.51 (1.54–8.00), for deaths 5.39 (3.00–9.68) and 3.38 (1.71–6.70), and for graft loss 1.30 (0.75–2.28) and 1.94 (1.04–3.27) in age and smoking history-adjusted analyses. <b><i>Conclusion:</i></b> Kidney and SPK transplant recipients with high AAC have 3-fold higher CV and mortality risk and poorer graft outcomes than recipients without AAC. AAC scoring may be useful in assessing and targeted risk-lowering strategies.
DOI: 10.6084/m9.figshare.9373601
title: Public collaboration-minute documents in the Svendborgproject - 2012-2015

description: Public documents from the Svendborgproject. Adding more PE in the schools of The municipality of Svendborg, Denmark
DOI: 10.6084/m9.figshare.9373601.v1
title: Public collaboration-minute documents in the Svendborgproject - 2012-2015

description: Public documents from the Svendborgproject. Adding more PE in the schools of The municipality of Svendborg, Denmark
DOI: 10.6084/m9.figshare.9369629
title: Supplementary Material for: Association of Myoinositol Transporters with Schizophrenia and Bipolar Disorder: Evidence from Human and Animal Studies

description: Evidence from animal and human studies has linked <i>myo</i>-inositol (MI) with the pathophysiology and/or treatment of psychiatric disorders such as schizophrenia and bipolar disorder. However, there is still controversy surrounding the definitive role of MI in these disorders. Given that brain MI is differentially regulated by three transporters – SMIT1, SMIT2 and/or HMIT (encoded by the genes: <i>SLC5A3</i>,<i> SLC5A11</i>,<i></i>and <i>SLC2A13</i>, respectively) – we used available datasets to describe the distribution in mouse and human brain of the different MI transporters and to examine changes in mRNA expression of these transporters in patients with schizophrenia and bipolar disorder. We found a differential distribution of the mRNA of each of the three MI transporters in both human and mouse brain regions. Interestingly, while individual neurons express SMIT1 and HMIT, non-neuronal cells express SMIT2, thus partially accounting for different uptake levels of MI and concordance to downstream second messenger signaling pathways. We also found that the expression of MI transporters is significantly changed in schizophrenia and bipolar disorder in a diagnostic-, brain region- and subtype-specific manner. We then examined the effects of germline deletion in mice of <i>Slc5a3</i> on behavioral phenotypes related to schizophrenia and bipolar disorder. This gene deletion produces behavioral deficits that mirror some specific symptoms of schizophrenia and bipolar disorder. Finally, chronic administration of MI was able to reverse particular, but not all, behavioral deficits in <i>Slc5a3</i> knockout mice; MI itself induced some behavioral deficits. Our data support a strong correlation between the expression of MI transporters and schizophrenia and bipolar disorder, and suggest that brain region-specific aberration of one or more of these transporters determines the partial behavioral phenotypes and/or symptomatic pattern of these disorders.
DOI: 10.6084/m9.figshare.9367919
title: Binding mode of a cationic porphyrin to parallel and antiparallel thrombin binding aptamer G-quadruplex

description: The spectral properties of <i>meso</i>-tetrakis (<i>N</i>-methylpyridinium-4-yl)porphyrin (TMPyP) in the presence of parallel and antiparallel G-quadruplexes formed from a thrombin-binding aptamer G-quadruplex (5′-G<sub>3</sub>T<sub>2</sub>G<sub>3</sub>TGTG<sub>3</sub>T<sub>2</sub>G<sub>3</sub>) were investigated in this study. Red shift and hypochromism in the Soret absorption band of TMPyP were observed after binding to both parallel and antiparallel G-quadruplexes. The extent of changes in the absorption spectra were similar for both conformers. No circular dichroism spectrum was induced in the Soret region for both parallel and antiparallel G-quadruplexes. This is suggest that there is no or very weak interaction between electric transitions of nucleobases and porphyrin molecule. The accessibility of the neutral quencher I<sub>2</sub> to the G-quadruplex-bound TMPyP was similar for both parallel and antiparallel G-quadruplexes. All these observations suggest that TMPyP was bound at the outside of the quadruplexes, and conceivably interacted with the phosphate group via a weak electrostatic interaction. Communicated by Ramaswamy H. Sarma
DOI: 10.6084/m9.figshare.9366509
title: test.xlsx

description: Private items can be edited/ deleted the same way as public items (outlined above). Remember to click save changes and this will not create a new version.
DOI: 10.6084/m9.figshare.9366341
title: Third-party libraries in mobile apps: When, How, and Why Developers Update Them - Appendix

description: This online appendix contains the following content.<br><br><b>apps.csv</b>The list of 2752 applications that we considered in our study. It also includes the information about the source code locations and Google Play Store links.<br><b>dependencies.csv</b>It is the list of the dependencies we extracted from the considered apps, including the categorization we manually applied starting from Maven.<br><b>technical_lag__data.zip</b>The data resulting from the technical lag analysis we performed. The folder includes a single `CSV` file for each of the considered apps.<br><b>technical_lag__evolution.csv</b>The final technical lag file, which includes all the considered apps.<br><b>trends__data.zip</b>The data resulted from the full mining process, divided by app. For each of the files, we report the uses and releases of the dependencies.<br><b>trends__graphs.zip</b>A graphical representation for the dependencies for each of the considered apps. We include a file for each combination of app and dependency.<br><b>patterns.csv</b>The result of the automatic and manual analysis we manually applied to each dependency uses for the considered apps. It reports the number of changes within commit history and the analysis on use patterns.
DOI: 10.6084/m9.figshare.9361502
title: Supplementary Material for: Skin Care and Synbiotics for Prevention of Atopic Dermatitis or Food Allergy in Newborn Infants: A 2 × 2 Factorial, Randomized, Non-Treatment Controlled Trial

description: <b><i>Background:</i></b> Atopic dermatitis (AD) and food allergy (FA) are common childhood diseases, which may either be interrelated or be the result of skin barrier disruption and gut mucosal dysbiosis. Although some evidence suggests the efficacy of emollients and synbiotics, there is no conclusive evidence on the use of these interventions alone or in combination. <b><i>Objectives:</i></b> This study is aimed at identifying the efficacy of emollients and synbiotics in preventing AD and FA in children during the first year of life. <b><i>Methods:</i></b> The babies of mothers recruited prenatally received either an emollient, synbiotic, both or neither. The intervention was carried out from birth up to 6 months of age. The age of occurrence of AD and FA were reported in multiple questionnaires at 1, 6, and 9 months and at 1 year of age. AD was diagnosed by a pediatrician at 9 months of age. <b><i>Results:</i></b> A ­total of 459 babies qualified for the outcome assessment at 1 year of age. Neither the emollient nor the synbiotic showed any effect on reducing the development of AD and FA at 1 year of age. <b><i>Conclusions:</i></b> This study did not provide any evidence to show that emollients and synbiotics, alone or in combination are sufficient to prevent the occurrence of AD or FA in children up to 1 year of age.
DOI: 10.6084/m9.figshare.9361148
title: PlayeRanks

description: If you use these data cite the following papers: <br><br>- Pappalardo et al., (2019) <b>A public data set of spatio-temporal match events in soccer competitions</b>, Nature Scientific Data 6:236, https://www.nature.com/articles/s41597-019-0247-7<br>- Pappalardo et al. (2019) <b>PlayeRank: Data-driven Performance Evaluation and Player Ranking in Soccer via a Machine Learning Approach</b>. ACM Transactions on Intellingent Systems and Technologies (TIST) 10, 5, Article 59 (September 2019), 27 pages. DOI: https://doi.org/10.1145/3343172 <br><br><br>The PlayeRank score of the players in the matches they played. The PlayeRank score indicate, in a range from 0 to 1, how good was that player in that match (0 unforgettably bad, 1 amazing). The score have been computed using the PlayeRank framework, if you use these data please cite the following paper: https://arxiv.org/abs/1802.04987. <br>Each document in the json file has the following fields:<br>- <b>goalScored</b>: the number of goals scored by the player in the match- <b>playerankScore</b>: the PlayeRank score of the player in the match- <b>matchId</b>: the identifier of the match- <b>playerId</b>: the identifier of the player- <b>roleCluster</b>: the role of player in the match, as computed by the PlayeRank framework - <b>minutesPlayed</b>: the minutes played by the player in the match<br>
DOI: 10.6084/m9.figshare.9361154
title: Modeling Soil Hydraulic Properties Using the Roughness-Triangular Pore Space Model

description: This is model data for the Roughness-Triangular Pore Space Model. The model output was used for revealing soil-born hydrogel effects on soil hydraulic properties.
DOI: 10.6084/m9.figshare.9357083
title: Characterization of novel small RNAs (sRNAs) contributing to the desiccation response of <i>Salmonella enterica</i> serovar Typhimurium

description: Noncoding RNA (ncRNA) modulation of gene expression has now been ubiquitously observed across all domains of life. An increasingly apparent role of ncRNAs is to coordinate changes in gene expressions in response to environmental stress. <i>Salmonella enterica</i>, a common food-born pathogen, is known for its striking ability to survive, adapt, and thrive in various unfavourable environments which makes it a particularly difficult pathogen to eliminate as well as an interesting model in which to study ncRNA contributions to cellular stress response. Mounting evidence now suggests that small RNAs (sRNAs) represent key regulators of <i>Salmonella</i> stress adaptation. Approximately 50–500 nucleotides in length, sRNAs regulate gene expression through complementary base pairing with molecular targets and have recently been suggested to outnumber protein-coding genes in bacteria. In this work, we employ small RNA transcriptome sequencing to characterize changes in the sRNA profiles of <i>Salmonella</i> in response to desiccation. In all, we identify 102 previously annotated sRNAs significantly differentially expressed during desiccation; and excitingly, 71 novel sRNAs likewise differentially expressed. Small transcript northern blotting and qRT-PCRs confirm the identities and expressions of several of our novel sRNAs, and computational analyses indicate the majority are highly conserved and structurally related to characterized sRNAs. Predicted sRNA targets include several proteins necessary for desiccation survival and this, in part, suggests a role for desiccation-regulated sRNAs in this stress response. Furthermore, we find individual knock-outs of two of the novel sRNAs identified herein, either sRNA1320429 or sRNA3981754, significantly impairs the ability of <i>Salmonella</i> to survive desiccation, confirming their involvements (and suggesting the potential involvements of other sRNAs we identify in this work) in the <i>Salmonella</i> response to desiccation.
DOI: 10.6084/m9.figshare.9357011
title: RoomRating.csv

description: Participants' rating for stress, fear and escape in virtual rooms