cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.19970047.v1
title: LINC00514 facilitates cell proliferation, migration, invasion, and epithelial-mesenchymal transition in non-small cell lung cancer by acting on the Wnt/β-catenin signaling pathway

description: The long non-coding RNA (lncRNA) LINC00514 was identified to play an essential oncogenic function in different human cancers, but its effects in non-small cell lung cancer (NSCLC) are yet to be elucidated. In this study, we evaluated the function of LINC00514 in NSCLC. LINC00514 expression and prognosis in NSCLC were analyzed using qRT-PCR and online bioinformatic tools. The bioeffects of LINC0514 in NSCLC cells were examined using cell counting kit-8, colony formation, and transwell assays. Western blotting was used to measure the expression of the target proteins. The LINC00514 regulation of the Wnt/β-catenin signaling pathway was assessed using a specific agonist (LiCl) and luciferase reporter assay. We found that LINC00514 expression was elevated in NSCLC cells and clinical samples and that increased LINC00514 expression predicted poorer patient prognosis. Silencing LINC00514 suppresses proliferation, migration, and invasion of NSCLC cells. Downregulation of LINC00514 inhibited Wnt/β-catenin signaling and epithelial-mesenchymal transition (EMT). Moreover, suppression of the biological phenotypes of NSCLC cells induced by LINC00514 gene silencing was restored after LiCl treatment. Finally, we found that silencing LINC00514 attenuated the growth of xenograft tumors in vivo. Altogether, this study provides the latest convincing evidence that LINC00514 facilitates the malignant biological behavior of NSCLC cells through activation of the Wnt/β-catenin pathway, which might offer a beneficial approach for the treatment of NSCLC.
DOI: 10.6084/m9.figshare.19970044.v1
title: Paeoniflorin alleviates the progression of retinal vein occlusion via inhibiting hypoxia inducible factor-1α/vascular endothelial growth factor/STAT3 pathway

description: Retinal vein occlusion (RVO) is a severe retinal vascular disease involving several complications, leading to weakening of vision and even blindness. Globally, over 16 million patients with RVO were found in the middle-aged population. Paeoniflorin (PF), a monomer of Taohong Siwu decoction, was reported to exhibit many pharmacological activities including anti-inflammatory, antioxidant, cardioprotective, and neuroprotective effects. However, the effect of PF on the progression of RVO remains unclear. In the current study, CCK8 assay was performed to investigate the cell viability. In addition, transwell assay and western blot were used to measure cell invasion and protein expression, respectively. Moreover, a mouse model of oxygen-induced dischemic retinopathy (OIR) was established. We found PF was able to inhibit the migration and angiogenesis of human retinal capillary endothelial cells under normoxia. Additionally, PF notably prevented hypoxia-induced angiogenesis of human retinal capillary endothelial cells via inhibiting hypoxia-inducible factor-1α (HIF-1α)/vascular endothelial growth factor (VEGF)/STAT3 pathway. Eventually, PF significantly alleviated the retinal lesions in the mouse with OIR. All in all, PF was able to alleviate the progression of retinal vein occlusion via inhibiting HIF-1α/VEGF/STAT3 pathway. These findings might provide some theoretical knowledge for exploring novel effective treatment for patients with RVO.
DOI: 10.6084/m9.figshare.19970047.v2
title: LINC00514 facilitates cell proliferation, migration, invasion, and epithelial-mesenchymal transition in non-small cell lung cancer by acting on the Wnt/β-catenin signaling pathway

description: The long non-coding RNA (lncRNA) LINC00514 was identified to play an essential oncogenic function in different human cancers, but its effects in non-small cell lung cancer (NSCLC) are yet to be elucidated. In this study, we evaluated the function of LINC00514 in NSCLC. LINC00514 expression and prognosis in NSCLC were analyzed using qRT-PCR and online bioinformatic tools. The bioeffects of LINC0514 in NSCLC cells were examined using cell counting kit-8, colony formation, and transwell assays. Western blotting was used to measure the expression of the target proteins. The LINC00514 regulation of the Wnt/β-catenin signaling pathway was assessed using a specific agonist (LiCl) and luciferase reporter assay. We found that LINC00514 expression was elevated in NSCLC cells and clinical samples and that increased LINC00514 expression predicted poorer patient prognosis. Silencing LINC00514 suppresses proliferation, migration, and invasion of NSCLC cells. Downregulation of LINC00514 inhibited Wnt/β-catenin signaling and epithelial-mesenchymal transition (EMT). Moreover, suppression of the biological phenotypes of NSCLC cells induced by LINC00514 gene silencing was restored after LiCl treatment. Finally, we found that silencing LINC00514 attenuated the growth of xenograft tumors in vivo. Altogether, this study provides the latest convincing evidence that LINC00514 facilitates the malignant biological behavior of NSCLC cells through activation of the Wnt/β-catenin pathway, which might offer a beneficial approach for the treatment of NSCLC.
DOI: 10.6084/m9.figshare.19970050.v1
title: Plumbagin relieves rheumatoid arthritis through nuclear factor kappa-B (NF-κB) pathway

description: This study aimed to explore the effects of plumbagin on rheumatoid arthritis (RA) and its mechanism. The RA cell model was simulated following the treatment of interleukin-1β (IL-1β). After the treatment of various concentrations of plumbagin, the impact of plumbagin on the cell viability was examined by 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. The collagen-induced arthritis (CIA) model was established using the solution of bovine type II collagen. Hematoxylin-eosin staining was used to observe the changes of ankle joint tissue, while enzyme-linked immunosorbent assay and western blot were applied to detect the level of inflammatory cytokines. Plumbagin inhibited the viability of human fibroblast-like synoviocytes (HFLS) at the concentration of 1 ~ 3.5 μM. The inhibitory effect of 1 μM plumbagin on cell proliferation was similar to that of methotrexate, the drug used as the positive control. Plumbagin downregulated the levels of inflammatory cytokines and matrix metalloproteinases (MMPs) in IL-1β-treated HFLS, and suppressed the activation of IκB and nuclear factor kappa-B (NF-κB) as well as the entry of p65 into the nucleus. It was also demonstrated in animal experiments that plumbagin inhibited the activation of NF-κB pathway, down-regulated the levels of tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) and MMPs, and alleviated joint damage in CIA-modeled mice. Collectively speaking, plumbagin might down-regulate the levels of inflammatory cytokines and MMPs through inhibiting the activation of the NF-κB pathway, thereby attenuating RA-induced damage to cells and joints. <b>Abbreviations</b>: CIA: Collagen-induced arthritis; ELISA: Enzyme-linked immuno sorbent assay; HFLS: Human fibroblast-like synoviocytes; IL-6: Interleukin-6; IL-1β: Interleukin-1β; NF-κB: nuclear factor kappa-B; MTT: 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide; MMPs: Matrix metalloproteinase; OD: Optical density; RA: Rheumatoid arthritis; SDS: Sodium dodecyl sulfate; SD: Standard deviation; TNF-α: Tumor necrosis factor-α; PVDF: Polyvinylidene fluoride.
DOI: 10.6084/m9.figshare.16821682.v1
title: Additional file 3 of Genome-wide selection signatures detection in Shanghai Holstein cattle population identified genes related to adaption, health and reproduction traits

description: Additional file 3
DOI: 10.6084/m9.figshare.16821688
title: Additional file 5 of Genome-wide selection signatures detection in Shanghai Holstein cattle population identified genes related to adaption, health and reproduction traits

description: Additional file 5
DOI: 10.6084/m9.figshare.23640012.v1
title: Additional file 1 of TRAF2 promotes M2-polarized tumor-associated macrophage infiltration, angiogenesis and cancer progression by inhibiting autophagy in clear cell renal cell carcinoma

description: Supplementary Material 1
DOI: 10.6084/m9.figshare.19445785
title: Additional file 10 of Integrated analysis of the lncRNA/circRNA-miRNA-mRNA expression profiles reveals novel insights into potential mechanisms in response to root-knot nematodes in peanut

description: Additional file 10: Supplementary Table 4. The differential expression circRNAs between infected and no-infected peanut.
DOI: 10.6084/m9.figshare.4233383
title: The diversification of granitoids and plate tectonic implications at the Archaean–Proterozoic boundary in the Bundelkhand Craton, Central India

description: Major and trace element concentrations and U-Pb results of granitoids from the Bundelkhand Craton
DOI: 10.6084/m9.figshare.4233380
title: The diversification of granitoids and plate tectonic implications at the Archaean–Proterozoic boundary in the Bundelkhand Craton, Central India

description: Major and trace element concentrations and U-Pb results of granitoids from the Bundelkhand Craton
DOI: 10.6084/m9.figshare.4233332
title: Percentage of outliers excluded from statistical analysis from The influence of aspect ratio and stroke pattern on force generation of a bat-inspired membrane wing

description: Prior to statistical analysis the data of coefficients of lift and drag for down- and upstroke, respectively, versus velocity ratio for these four cases was grouped into 15 bins for the five different wings individually. In each bin, all data points with a force coefficient more than ± 1 standard deviation from the mean of the force coefficient in the respective bin were excluded from further analysis. The remaining data points per bin were averaged and subjected to an ANCOVA analysis.
DOI: 10.6084/m9.figshare.4233332.v1
title: Percentage of outliers excluded from statistical analysis from The influence of aspect ratio and stroke pattern on force generation of a bat-inspired membrane wing

description: Prior to statistical analysis the data of coefficients of lift and drag for down- and upstroke, respectively, versus velocity ratio for these four cases was grouped into 15 bins for the five different wings individually. In each bin, all data points with a force coefficient more than ± 1 standard deviation from the mean of the force coefficient in the respective bin were excluded from further analysis. The remaining data points per bin were averaged and subjected to an ANCOVA analysis.
DOI: 10.6084/m9.figshare.4233320
title: Phase-averaged force and inertial data of all data trials of the five different wings from The influence of aspect ratio and stroke pattern on force generation of a bat-inspired membrane wing

description: The lift and drag data of the five different aspect ratio wings was stored in a MATLAB structure and then converted to XML. For easiest access use xml2mat (available on https://www.mathworks.com/matlabcentral/fileexchange) to convert back to a MATLAB structure. The MATLAB structure contained 5 structures. Each of these structures contains fields named modelID, data and inertia. The structure data is a 5-D matrix, the structure inertia is a 4-D matrix of size. Both structures, data and inertia, have two fields, L and D, which are 2-D matrices of type double, where each column represents one phase-averaged wingbeat cycle. All force data are given in Newton. The data and inertia matrices are sorted so that each combination of test variables per model (freestream velocity, U, downstroke ratio, DR, stroke amplitude angle, a, sweep amplitude angle, b, and flapping frequency, f) is uniquely identified. The order for the data matrix is: [U,DR,a,b,f]. The order for the inertia matrix is: [DR,a,b,f]. U runs from 1 to 2, corresponding to 5.0 m/s and 7.5 m/s; DR runs from 1 to 3, corresponding to to downstroke ratios of .44, .50, .56; a runs from 1 to 7, corresponding to angles from 15° to 110° in increments of 15°; b runs 1 to 5, corresponding to angles from 15° to 55° in increments of 10°; f runs from 1 to 6, corresponding to frequencies of 2, 4, 6 8, 9, and 10 Hz; Example: Access to lift data of the Eptesicus baseline stroke of model AR35bl at a freestream velocity of 5 m/s: AR35bl.data(1,2,7,5,5).L
DOI: 10.6084/m9.figshare.4233320.v1
title: Phase-averaged force and inertial data of all data trials of the five different wings from The influence of aspect ratio and stroke pattern on force generation of a bat-inspired membrane wing

description: The lift and drag data of the five different aspect ratio wings was stored in a MATLAB structure and then converted to XML. For easiest access use xml2mat (available on https://www.mathworks.com/matlabcentral/fileexchange) to convert back to a MATLAB structure. The MATLAB structure contained 5 structures. Each of these structures contains fields named modelID, data and inertia. The structure data is a 5-D matrix, the structure inertia is a 4-D matrix of size. Both structures, data and inertia, have two fields, L and D, which are 2-D matrices of type double, where each column represents one phase-averaged wingbeat cycle. All force data are given in Newton. The data and inertia matrices are sorted so that each combination of test variables per model (freestream velocity, U, downstroke ratio, DR, stroke amplitude angle, a, sweep amplitude angle, b, and flapping frequency, f) is uniquely identified. The order for the data matrix is: [U,DR,a,b,f]. The order for the inertia matrix is: [DR,a,b,f]. U runs from 1 to 2, corresponding to 5.0 m/s and 7.5 m/s; DR runs from 1 to 3, corresponding to to downstroke ratios of .44, .50, .56; a runs from 1 to 7, corresponding to angles from 15° to 110° in increments of 15°; b runs 1 to 5, corresponding to angles from 15° to 55° in increments of 10°; f runs from 1 to 6, corresponding to frequencies of 2, 4, 6 8, 9, and 10 Hz; Example: Access to lift data of the Eptesicus baseline stroke of model AR35bl at a freestream velocity of 5 m/s: AR35bl.data(1,2,7,5,5).L
DOI: 10.6084/m9.figshare.4233314
title: Results of ANCOVA analysis and pairwise comparison from The influence of aspect ratio and stroke pattern on force generation of a bat-inspired membrane wing

description: Table A: MATLAB's Statistical Toolbox was used to perform an ANCOVA analysis was used to calculate linear regression fits for the dependency of the coefficient of lift and coefficient of drag on velocity ratio (figure 8). This table summarises the results of testing for the similarity of the linear regressions that fit the individual data sets of the five different models to a linear regression that would fit the data of all models combined. Presented are the deviation of the slopes of the individual fits from the slope of the regression that would fit all data. P-values of p~\textgreater~0.05 indicate that the slope of the individual set is not different from the slope of the regression of all data with a probability of 95%. Table B: P-values (rounded to two decimal places) of the pairwise comparisons of the slopes of the regression lines among the five models. The slopes of the regression lines were tested separately for coefficient of lift and drag of downstoke and upstroke, respectively.
DOI: 10.6084/m9.figshare.4233239
title: Pseudokarst caves of the Outer Western Carpathians, Czechia

description: The paper presents complex results of a dataset related to the pseudokarst caves in the area of the Czech Outer Western Carpathians. We collected the data from all 130 discovered and described caves of different types and dimensions in various geomorphic units and lithologies. We mainly focus on the results of the morphometric parameters of the caves as well as of the areas with their entrances. The final map sheet presents the Main Map with the position of the caves, their size category, type, classification of the position within the slope deformation and natural protection status. Moreover, the final map sheet also contains a supplementary map of the distribution of the caves, diagrams of their morphometric parameters, detailed maps of Mraznica and Cyrilka Caves, a graph of overwintering bat species in Cyrilka Cave and structural measurement diagrams. The map is intended to be used as introductory material into the problems of pseudokarst caves.
DOI: 10.6084/m9.figshare.4233239.v1
title: Pseudokarst caves of the Outer Western Carpathians, Czechia

description: The paper presents complex results of a dataset related to the pseudokarst caves in the area of the Czech Outer Western Carpathians. We collected the data from all 130 discovered and described caves of different types and dimensions in various geomorphic units and lithologies. We mainly focus on the results of the morphometric parameters of the caves as well as of the areas with their entrances. The final map sheet presents the Main Map with the position of the caves, their size category, type, classification of the position within the slope deformation and natural protection status. Moreover, the final map sheet also contains a supplementary map of the distribution of the caves, diagrams of their morphometric parameters, detailed maps of Mraznica and Cyrilka Caves, a graph of overwintering bat species in Cyrilka Cave and structural measurement diagrams. The map is intended to be used as introductory material into the problems of pseudokarst caves.
DOI: 10.6084/m9.figshare.4233227
title: Supporting data for Cat. Sci. Tech. 2016

description: TEM images of the 4 samples of Pd nanoparticles
DOI: 10.6084/m9.figshare.4233227.v1
title: Supporting data for Cat. Sci. Tech. 2016

description: TEM images of the 4 samples of Pd nanoparticles
DOI: 10.6084/m9.figshare.4233215
title: "The process of mental contamination and mental correction" after Wilson & Brekke (1994) Figure 1

description: Reworking of Wilson & Brekke (1994) Figure 1 "The process of mental contamination and mental correction".<br><br>Wilson, T. D., & Brekke, N. (1994). Mental contamination and mental correction: unwanted influences on judgments and evaluations. Psychological bulletin, 116(1), 1171-142.<br><br>Made with https://www.draw.io/<br><br>To modify load XML file in draw.io<br><br><br>
DOI: 10.6084/m9.figshare.4233215.v1
title: "The process of mental contamination and mental correction" after Wilson & Brekke (1994) Figure 1

description: Reworking of Wilson & Brekke (1994) Figure 1 "The process of mental contamination and mental correction".<br><br>Wilson, T. D., & Brekke, N. (1994). Mental contamination and mental correction: unwanted influences on judgments and evaluations. Psychological bulletin, 116(1), 1171-142.<br><br>Made with https://www.draw.io/<br><br>To modify load XML file in draw.io<br><br><br>
DOI: 10.6084/m9.figshare.4233182
title: Data.xlsx

description: The<b> CCPI</b> and <b>CMAD</b> data from 2012-2015 are collected.
DOI: 10.6084/m9.figshare.4233155
title: Supplementary Material for: Effect of a Dialysis Access Coordinator on Preemptive Access Placement among Veterans: A Quality Improvement Initiative

description: <i>Background and Objectives:</i> Preemptive placement of permanent dialysis access is recommended in order to reduce the morbidity associated with central venous catheters. We assessed the effect of a dialysis access coordinator on preemptive access placement in veterans who are at high risk for end-stage renal disease (ESRD). <i>Design, Setting, Participants, and Measurements:</i> Pre-post evaluation of a dialysis access coordinator in the nephrology clinics of the Veterans Affairs Palo Alto. The access coordinator streamlined access referrals, prioritized surgical waiting lists and addressed patient barriers. We compared the frequency of preemptive access referral, surgery, and use for dialysis during the intervention period, July 1, 2013 to May 31, 2016, to a pre-intervention period, January 1, 2011 to December 31, 2013, among all patients with a predicted 1-year risk for ESRD ≥20%. <i>Results:</i> There were 156 patients in the historical cohort and 131 in the intervention cohort. The mean age was 69.9 ± 11.6 years and the mean estimated glomerular filtration rate was 14.5 ± 5.7 ml/min/1.73 m2. The intervention was associated with an 11.8% increase in access referral (p value = 0.03), and a 9.4% increase in completed access surgery (p value = 0.05). Increases in permanent access at the start of dialysis (15.2%), and functional permanent access at the start of dialysis (12.4%) did not reach statistical significance. Among patients who received access surgery, there was no significant difference in the prevalence of unused access. <i>Conclusions:</i> Implementation of an access coordinator was associated with a modest increase in preemptive access placement among patients who are at high risk for ESRD without increasing the prevalence of unused access.
DOI: 10.6084/m9.figshare.4233155.v1
title: Supplementary Material for: Effect of a Dialysis Access Coordinator on Preemptive Access Placement among Veterans: A Quality Improvement Initiative

description: <i>Background and Objectives:</i> Preemptive placement of permanent dialysis access is recommended in order to reduce the morbidity associated with central venous catheters. We assessed the effect of a dialysis access coordinator on preemptive access placement in veterans who are at high risk for end-stage renal disease (ESRD). <i>Design, Setting, Participants, and Measurements:</i> Pre-post evaluation of a dialysis access coordinator in the nephrology clinics of the Veterans Affairs Palo Alto. The access coordinator streamlined access referrals, prioritized surgical waiting lists and addressed patient barriers. We compared the frequency of preemptive access referral, surgery, and use for dialysis during the intervention period, July 1, 2013 to May 31, 2016, to a pre-intervention period, January 1, 2011 to December 31, 2013, among all patients with a predicted 1-year risk for ESRD ≥20%. <i>Results:</i> There were 156 patients in the historical cohort and 131 in the intervention cohort. The mean age was 69.9 ± 11.6 years and the mean estimated glomerular filtration rate was 14.5 ± 5.7 ml/min/1.73 m2. The intervention was associated with an 11.8% increase in access referral (p value = 0.03), and a 9.4% increase in completed access surgery (p value = 0.05). Increases in permanent access at the start of dialysis (15.2%), and functional permanent access at the start of dialysis (12.4%) did not reach statistical significance. Among patients who received access surgery, there was no significant difference in the prevalence of unused access. <i>Conclusions:</i> Implementation of an access coordinator was associated with a modest increase in preemptive access placement among patients who are at high risk for ESRD without increasing the prevalence of unused access.
DOI: 10.6084/m9.figshare.4233119
title: A MANY-OBJECTIVE OPTIMIZATION AND VISUAL ANALYTICS APPROACH TO PROJECT SELECTION FOR INTEGRATED CATCHMENT MANAGEMENT

description: · Data Set S1. An excel spreadsheet containing stormwater harvesting and green score determined by stakeholders, and calculations for costings and water quality performance of individual BMPs. Filename: ds01.xlsx · Data Set S2.<b> </b>A compressed file containing inputs and an executable for the Pareto Ant Colony Optimization Algorithm (PACOA) that can be run on a Windows desktop computer to replicate the optimization results. Filename: ds02.rar · Data Set S3. An excel spreadsheet containing the objective function values, decision options, and alternative data (catchment size, breakdown of benefits by Council) of the Pareto optimal solutions determined by sorting the optimization results for non-dominance in objective space. Filename: ds03.csv · Data Set S4. A .ddv that can be opened in the DiscoveryDV visual analytics program, containing interactive visualization of the Pareto optimal solution data from Data Set S3. Filename: ds04.ddv <br>