cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.6388466.v1
title: Association between tumor necrosis factor alpha rs1800629 polymorphism and risk of osteoarthritis in a Chinese population

description: Osteoarthritis (OA) is the most common degenerative disease affecting articular cartilage. Some studies indicate that tumor necrosis factor alpha (TNF-α) gene rs1800629 polymorphism was associated with OA risk among Caucasian populations. To examine the role of this candidate gene in Asian populations, we conducted a hospital-based case-control study involving 257 knee OA patients and 305 controls in a Chinese population. Genotyping was performed using a custom-by-design 48-Plex single nucleotide polymorphism (SNP) Scan™ kit. Our study indicated that the AA genotype of TNF-α rs1800629 polymorphism was associated with increased risk of OA. Subsequently, we conducted a meta-analysis and found that rs1800629 polymorphism increased the risk of OA in the recessive and homozygous models. Stratification analysis of ethnicity also obtained a significant association among Asian populations. In conclusion, TNF-α rs1800629 polymorphism confers susceptibility to OA, especially among Asians. Larger studies with more diverse ethnic populations are needed to confirm these results.
DOI: 10.6084/m9.figshare.6388448
title: PD-1/PD-L1 regulates Treg differentiation in pregnancy-induced hypertension

description: Pregnancy-induced hypertension (PIH) causes significant maternal and fetal morbidity and mortality. A decreased number of regulatory T (Treg) cells is associated with the pathogenesis of PIH. The programmed cell death-1 (PD-1)/PD-ligand 1 (PD-L1) pathway is critical to normal pregnancy (NP) by promoting Treg cell development. However, the relationship between PD-1/PD-L1 and Treg differentiation in PIH has not been fully elucidated. In this study, venous blood was obtained from 20 NP and 58 PIH patients. Peripheral blood mononuclear cells (PBMCs) were isolated from venous blood. The levels of Treg-related cytokines (TGF-β, IL-10, and IL-35) in serum and PBMCs were measured by ELISA. The percentage of Treg cells in PBMCs was assessed by flow cytometry. The mRNA levels of Treg-specific transcription factor Foxp3 in PBMCs, and PD-1 and PD-L1 in Treg cells were detected by qRT-PCR. The protein levels of PD-1 and PD-L1 in Treg cells were evaluated by western blot. The serum levels of TGF-β, IL-10, IL-35, and Foxp3 mRNA expression and CD4+CD25+ Treg cell percentage in PBMCs were decreased in PIH. Furthermore, a significant increase of PD-1 in Treg cells was found in PIH compared with NP. In addition, PD-L1 Fc, an activator of PD-1/PD-L1 pathway, increased Treg cell percentage, enhanced Foxp3 mRNA expression, and elevated levels of TGF-β, IL-10, and IL-35 in PBMCs. However, anti-PD-L1 mAb exerted a reverse effect. These findings revealed that PD-L1 Fc had a favorable effect on Treg cell differentiation, indicating a potential therapeutic value of PD-1/PD-L1 pathway for PIH treatment.
DOI: 10.6084/m9.figshare.16869780
title: Additional file 1 of Differential gene expression-based connectivity mapping identified novel drug candidate and improved Temozolomide efficacy for Glioblastoma

description: Additional file 1: Supplementary methods. Table S1 Drugs common across the four datasets. Table S2 Inhibitor selectivity. Table S3 PCI-24781 inhibits GBM cell viability. Table S4 List of antibodies used in this study. Figure S1: PCI-24781 decreases the viability of MGMT expressing human U-118MG and EGFRvIII, expressing mouse syngeneic GBM cells. Figure S2: PCI-24781 + TMZ combination significantly decreases the tumorigenicity of EGFRvIII+, p16Flox/Flox, GFAP Cre + mouse syngeneic GBM cells. Figure S3: PCI-24781 shows strong synergistic effects with TMZ in GBM cells. Figure S4: PCI-24781 induces nuclear enlargement in U-118MG cells. Figure S5: Genotyping of GEM GBM model.
DOI: 10.6084/m9.figshare.19522255.v5
title: Data scientist search behaviour

description: The repo contains artifacts of survey study and interviews with data scientists on understanding their search behaviour in online resources.
DOI: 10.6084/m9.figshare.19522255.v6
title: Data scientist search behaviour

description: The repo contains artifacts of survey study and interviews with data scientists on understanding their search behaviour in online resources.
DOI: 10.6084/m9.figshare.19425977
title: Zhang2022_JGR_Haiyuan

description: The zip file includes the teleseismic and local event data for Zhang2022_JGR. Please read readme.txt for details.
DOI: 10.6084/m9.figshare.19425977.v2
title: Zhang2022_JGR_Haiyuan

description: The zip file includes the teleseismic and local event data for Zhang2022_JGR. Please read readme.txt for details.
DOI: 10.6084/m9.figshare.19425977.v1
title: Zhang2022_JGR_Haiyuan

description: The zip file includes the teleseismic and local event data for Zhang2022_JGR. Please read readme.txt for details.
DOI: 10.6084/m9.figshare.20069897.v3
title: Agricultural Crop- and Animal-specific Ammonia Emission Inventory

description: All products (crop- and animal- specific NH3 emission inventories in the time span of 1961-2018) are provided in TIFF format at a spatial resolution of 0.5 degree by 0.5 degree (latitude by longitude) at figshare. The unit is kg N yr-1, stored in two folders (cropland and livestock).
DOI: 10.5676/dwd_cdc/oceanrain/v002
title: OceanRAIN Release 2.0: the second release of the in-situ shipboard global ocean surface-reference dataset of all water cycle components

description: OceanRAIN Release 2.0 (Ocean Rainfall And Ice-phase precipitation measurement Network) provides in-situ along-track shipboard data of precipitation, evaporation and the resulting freshwater flux at 1-min resolution over the global oceans from 10 June 2010 to 31 December 2018. More than 11.6 million minutes with 82 parameters from 8 ships cover all routinely measured atmospheric and oceanographic state variables along with those required to derive the turbulent heat fluxes. The precipitation parameter is based on measurements of the optical disdrometer ODM470 specifically designed for all-weather shipboard operations. The rain, snow and mixed-phase precipitation occurrence, intensity and accumulation are derived from particle size distributions. Additionally, microphysical parameters and radar-related parameters are provided. Addressing the need for high-quality in-situ precipitation data over the global oceans, OceanRAIN-2.0 and -1.0 are the first comprehensive along-track in-situ water cycle surface reference datasets for satellite product validation and retrieval calibration of the GPM (Global Precipitation Measurement) era, to improve the representation of precipitation and air-sea interactions in re-analyses and models, and to improve understanding of water cycle processes over the global oceans. The OceanRAIN-2.0 dataset extends the precursor version OceanRAIN Release 1.0 (Klepp et al., 2018) by increasing the data volume by a factor of 1.7. Seven new radar-related parameters are added to the OceanRAIN-2.0 database including a complete reprocessing of the OceanRAIN-1.0 data. The S-Band radar data and the inclusion of the one-way attenuation for all four radar bands was highly demanded by the international science community working with the OceanRAIN data and thus triggered the reprocessing. The OceanRAIN-2.0 dataset comprises more than 9,100,000 valid minutes of observations of which 88% are true-zero minutes that are minutes with measured precipitation absence. 12% of the total minutes with precipitation split into 63% with rain, 31% with snow and 6% with mixed-phase precipitation.
DOI: 10.6084/m9.figshare.20070107
title: Test data for combined heat and power dispatch

description: combined heat and power dispatch
DOI: 10.6084/m9.figshare.20055269
title: Hand port site infection

description: Handport site infection
DOI: 10.6084/m9.figshare.20055269.v2
title: Hand port site infection

description: Handport site infection
DOI: 10.6084/m9.figshare.20055269.v1
title: Hand port site infection

description: Handport site infection
DOI: 10.6084/m9.figshare.24279409
title: DATASET seniors formal caregivers

description: This dataset is the basis for a study in which examines the emotional states of social workers caring for the elderly during the COVID-19 pandemic and reveals connections with situations handled during the pandemic. N=253 social workers participated in the research. The study uses the PHQ-9 and GAD-7 questionnaires to reveal that 35% experienced moderate/severe depression and 27% reported moderate to severe anxiety. Research finds inconclusive associations with personal factors, but highlights the importance of work-related factors. It turned out that respondents focused on behavior and motivation, communication and competence. The results revealed a surprisingly low number of conflicts between work and family. Among other things, it was found that people with higher depression describe more problems where finances and non-work relationships play a central role. Finally, the study examines the thoughts of social workers and outlines what changes they plan to make as a result of this experience - respondents express a determination to change work methods (more IT) and professional content (less administration, more direct work and communication with clients). The findings underscore the resilience and adaptability of social workers and demonstrate their ability to draw positive outcomes from adversity.
DOI: 10.6084/m9.figshare.24279409.v1
title: DATASET seniors formal caregivers

description: This dataset is the basis for a study in which examines the emotional states of social workers caring for the elderly during the COVID-19 pandemic and reveals connections with situations handled during the pandemic. N=253 social workers participated in the research. The study uses the PHQ-9 and GAD-7 questionnaires to reveal that 35% experienced moderate/severe depression and 27% reported moderate to severe anxiety. Research finds inconclusive associations with personal factors, but highlights the importance of work-related factors. It turned out that respondents focused on behavior and motivation, communication and competence. The results revealed a surprisingly low number of conflicts between work and family. Among other things, it was found that people with higher depression describe more problems where finances and non-work relationships play a central role. Finally, the study examines the thoughts of social workers and outlines what changes they plan to make as a result of this experience - respondents express a determination to change work methods (more IT) and professional content (less administration, more direct work and communication with clients). The findings underscore the resilience and adaptability of social workers and demonstrate their ability to draw positive outcomes from adversity.
DOI: 10.5281/zenodo.8427304
title: Dataset for publication ("An antimicrobial peptide expression platform for targeting pathogenic bacterial species")

description: Experimental dataset used to create Figures 2-4 of manuscript: "An antimicrobial peptide expression platform for targeting pathogenic bacterial species" (preprint doi: https://doi.org/10.1101/2023.10.09.561505).
DOI: 10.5281/zenodo.8427282
title: Governança de Risco em Empresas Seguradoras dos EUA

description: A base de dados técnico-científica consiste numa amostra de dados de governança corporativa, governança de risco e dados contábeis e financeiros de 91 empresas seguradoras de capital aberto nos EUA. Esses dados foram coletados dos relatórios anuais de governança corporativa DEF 14A (proxy statement), Formulários 3 e 4 do sistema EDGAR da U.S. Securities and Exchange Commission. Foram também obtidos dados da Lexis Nexis Academic database, LinkedIn e S&P Capital IQ database para composição final da base. Essa base de dados oferece a possibilidade de replicar os resultados de pesquisas empíricos sobre o tema ERM dentro do universo de seguradoras americanas. Assim, a base de dados gera alto impacto potencial para diversos usuários, tais como sociedade, mercado, executivos e acadêmicos. A base de dados técnico-científica foi usada para desenvolvimento de artigos técnicos e científicos como, por exemplo, “Do chief risk officers’ committee participation and compensation relate to firm value? An empirical investigation of the insurance industry” disponibilizado na SSRN (https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3355854) e outros, em avaliação em períodos científicos.
description: Silva, A. F.; Silva, J. R. (2023). Governança de Risco em Empresas Seguradoras dos EUA. PPGCFTG - Programa de Pós- Graduação em Controladoria, Finanças e Tecnologias de Gestão. Zenodo. DOI: 10.5281/zenodo.8427283.
DOI: 10.5281/zenodo.8427283
title: Governança de Risco em Empresas Seguradoras dos EUA

description: A base de dados técnico-científica consiste numa amostra de dados de governança corporativa, governança de risco e dados contábeis e financeiros de 91 empresas seguradoras de capital aberto nos EUA. Esses dados foram coletados dos relatórios anuais de governança corporativa DEF 14A (proxy statement), Formulários 3 e 4 do sistema EDGAR da U.S. Securities and Exchange Commission. Foram também obtidos dados da Lexis Nexis Academic database, LinkedIn e S&P Capital IQ database para composição final da base. Essa base de dados oferece a possibilidade de replicar os resultados de pesquisas empíricos sobre o tema ERM dentro do universo de seguradoras americanas. Assim, a base de dados gera alto impacto potencial para diversos usuários, tais como sociedade, mercado, executivos e acadêmicos. A base de dados técnico-científica foi usada para desenvolvimento de artigos técnicos e científicos como, por exemplo, “Do chief risk officers’ committee participation and compensation relate to firm value? An empirical investigation of the insurance industry” disponibilizado na SSRN (https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3355854) e outros, em avaliação em períodos científicos.
description: Silva, A. F.; Silva, J. R. (2023). Governança de Risco em Empresas Seguradoras dos EUA. PPGCFTG - Programa de Pós- Graduação em Controladoria, Finanças e Tecnologias de Gestão. Zenodo. DOI: 10.5281/zenodo.8427283.
DOI: 10.5281/zenodo.8316094
title: Analysis of AaH-II effect in the axon initial of neocortical pyramidal neurons

description: This dataset contains data in HEK293 neurons expressing either human Na<sub>v</sub>1.2 or human Na<sub>v</sub>1.6 and whole-cell electrophysiological recordings and imaging data from neocortical layer-5 pyramidal neuron in brain slices of the mouse. This dataset is used in the paper: Abbas F, Blömer LA, Millet H, Montnach J, De Waard M, Canepari M. Analysis of the effect of the scorpion toxin AaH-II on action potential generation in the axon initial segment. bioRxiv, 2023. https://www.biorxiv.org/content/10.1101/2023.10.06.561226v1
DOI: 10.5281/zenodo.8316093
title: Analysis of AaH-II effect in the axon initial of neocortical pyramidal neurons

description: This dataset contains data in HEK293 neurons expressing either human Na<sub>v</sub>1.2 or human Na<sub>v</sub>1.6 and whole-cell electrophysiological recordings and imaging data from neocortical layer-5 pyramidal neuron in brain slices of the mouse. This dataset is used in the paper: Abbas F, Blömer LA, Millet H, Montnach J, De Waard M, Canepari M. Analysis of the effect of the scorpion toxin AaH-II on action potential generation in the axon initial segment. bioRxiv, 2023. https://www.biorxiv.org/content/10.1101/2023.10.06.561226v1
DOI: 10.5281/zenodo.8425323
title: Enabling population protein dynamics through Bayesian modeling

description: The knowledge of protein dynamics or turnover in patients provides invaluable information related to certain diseases, drug efficacy, or biological processes. A great corpus of experimental and computational methods has been developed, including by us, in the case of human patients followed <em>in vivo</em>. Moving one step further, we propose here a new modeling approach to capture the highly relevant notion of population protein dynamics. Using two data sets, we show that models inspired by population pharmacokinetics can accurately capture protein turnover within a cohort of individuals, even in presence of substantial inter-individual variability. R scripts<br> --------- The script BUGS-SILK-7.R computes protein dynamics models for one patient at a time. It was used<br> to explore the possibility to apply Bayesian modeling to SILK data. The script BUGS-pop-models.R computes the population protein dynamics Bayesian models. Note that the script should work provided they are run with all the data folders<br> being subfolders of the working directory. <br> Data folders<br> ------------ HRMS (unbiased proteomics protocol, see Lehmann, et al., Anal Chem, 2019) folders contain<br> the results of the QNB analysis. One folder per fluid (CSF-HRMS-05-2021 & plasma-HRMS-05-2021).<br> Analysis results are provided in a tabulated text file in each case with individual protein<br> parameters. These parameter values are used to build prior distributions in the new paper. TQ (targeted MRM protocol) folders contain the results of the QNB analysis, which are the input<br> data for this paper. These are stored in the CSF-TQ-05-2021/models & plasma-TQ-05-2021/models<br> folders. In each case, a plot of the protein model is provided for reference (.pdf files)<br> as well as a table listing each observed RIA (-final-selection.txt files) and another table<br> providing the QNB model parameters (-bootstrap.txt files). In addition, thq TQ folders contain the results of the Bayesian population modeling. The<br> folders CSF-TQ-05-2021/BUGS-models & plasma-TQ-05-2021/BUGS-models contain the models<br> obtained with the non-informative prior.The folders CSF-TQ-05-2021/BUGS-models-prior &<br> plasma-TQ-05-2021/BUGS-models-prior contain the models obtained with the informative prior<br> built from the HRMS data. HRMS and TQ folders are respectively zipped under HRMS.folders.plasma-and-csf.zip <br> and TQ.folders.plasma-and-csf.zip files.
DOI: 10.5281/zenodo.8425322
title: Enabling population protein dynamics through Bayesian modeling

description: The knowledge of protein dynamics or turnover in patients provides invaluable information related to certain diseases, drug efficacy, or biological processes. A great corpus of experimental and computational methods has been developed, including by us, in the case of human patients followed <em>in vivo</em>. Moving one step further, we propose here a new modeling approach to capture the highly relevant notion of population protein dynamics. Using two data sets, we show that models inspired by population pharmacokinetics can accurately capture protein turnover within a cohort of individuals, even in presence of substantial inter-individual variability. R scripts<br> --------- The script BUGS-SILK-7.R computes protein dynamics models for one patient at a time. It was used<br> to explore the possibility to apply Bayesian modeling to SILK data. The script BUGS-pop-models.R computes the population protein dynamics Bayesian models. Note that the script should work provided they are run with all the data folders<br> being subfolders of the working directory. <br> Data folders<br> ------------ HRMS (unbiased proteomics protocol, see Lehmann, et al., Anal Chem, 2019) folders contain<br> the results of the QNB analysis. One folder per fluid (CSF-HRMS-05-2021 & plasma-HRMS-05-2021).<br> Analysis results are provided in a tabulated text file in each case with individual protein<br> parameters. These parameter values are used to build prior distributions in the new paper. TQ (targeted MRM protocol) folders contain the results of the QNB analysis, which are the input<br> data for this paper. These are stored in the CSF-TQ-05-2021/models & plasma-TQ-05-2021/models<br> folders. In each case, a plot of the protein model is provided for reference (.pdf files)<br> as well as a table listing each observed RIA (-final-selection.txt files) and another table<br> providing the QNB model parameters (-bootstrap.txt files). In addition, thq TQ folders contain the results of the Bayesian population modeling. The<br> folders CSF-TQ-05-2021/BUGS-models & plasma-TQ-05-2021/BUGS-models contain the models<br> obtained with the non-informative prior.The folders CSF-TQ-05-2021/BUGS-models-prior &<br> plasma-TQ-05-2021/BUGS-models-prior contain the models obtained with the informative prior<br> built from the HRMS data. HRMS and TQ folders are respectively zipped under HRMS.folders.plasma-and-csf.zip <br> and TQ.folders.plasma-and-csf.zip files.
DOI: 10.23719/1529553
title: GLIMR_viewing

description: Code and viewing geometries for computing sun glint, wind speed, sun and satellite position, spatial resolution, signal-to-noise, and hours per day of observation.
DOI: 10.23719/1529608
title: Focus group data for factors in homeowners’ willingness to adopt IA systems

description: Dataset is a Microsoft Word file that contains the transcripts of five focus groups of adopters and prospective adopters of innovative/alternative septic systems. Focus group participants were asked a series of questions to better understand why they would or would not choose to adopt the alternative and innovative septic systems.
DOI: 10.5281/zenodo.8427495
title: Data set for Exploring Machine Learning-Based Methods for anomalies detection: Evidence from cryptocurrencies

description: <strong>Exploring Machine Learning-Based Methods for anomalies detection: Evidence from cryptocurrencies</strong>
DOI: 10.5281/zenodo.8427494
title: Data set for Exploring Machine Learning-Based Methods for anomalies detection: Evidence from cryptocurrencies

description: <strong>Exploring Machine Learning-Based Methods for anomalies detection: Evidence from cryptocurrencies</strong>
DOI: 10.5517/ccdc.csd.cc2f4952
title: CCDC 2238453: Experimental Crystal Structure Determination

description: Related Article: Claire Casaday|2023|CSD Communication|||
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2f49c8
title: CCDC 2238459: Experimental Crystal Structure Determination

description: Related Article: Claire Casaday, Cristin Juda, Ryan Clarke, Theodore Betley|2023|CSD Communication|||
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2f8t8t
title: CCDC 2242796: Experimental Crystal Structure Determination

description: Related Article: Wei Zhao|2023|CSD Communication|||
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2g4r2g
title: CCDC 2268675: Experimental Crystal Structure Determination

description: Related Article: ling lingjiejie|2023|CSD Communication|||
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.