cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.7795706.v1
title: Dataset after validations: Updating the global occurrence of Culicoides imicola, a vector for emerging viral diseases

description: The data contains an updated and comprehensive global database of Culicoides imicola occurrence, consisting of 1039 geo-positioned records from 50 countries around the world. The data also documented the climatic, livestock demographic and land cover characteristics of the occurrence points.
DOI: 10.6084/m9.figshare.7795688.v1
title: ai-als-data_codebook.txt

description: Synthetic data from an Artificial Intelligence-enabled Adaptive Learning System
DOI: 10.25376/hra.7795592
title: aat0344_Combined version.pdf

description: Fibrosis is the major determinant of morbidity and mortality in patients with nonalcoholic steatohepatitis (NASH)<br>but has no approved pharmacotherapy in part because of incomplete understanding of its pathogenic mechanisms.<br>Here, we report that hepatocyte Notch activity tracks with disease severity and treatment response in patients with<br>NASH and is similarly increased in a mouse model of diet-induced NASH and liver fibrosis. Hepatocyte-specific<br>Notch loss-of-function mouse models showed attenuated NASH-associated liver fibrosis, demonstrating causality<br>to obesity-induced liver pathology. Conversely, forced activation of hepatocyte Notch induced fibrosis in both<br>chow- and NASH diet–fed mice by increasing Sox9-dependent Osteopontin (Opn) expression and secretion from hepatocytes, which activate resident hepatic stellate cells. In a cross-sectional study, we found that OPN explains<br>the positive correlation between liver Notch activity and fibrosis stage in patients. Further, we developed a Notch<br>inhibitor [Nicastrin antisense oligonucleotide (Ncst ASO)] that reduced fibrosis in NASH diet–fed mice. In summary,<br>these studies demonstrate the pathological role and therapeutic accessibility of the maladaptive hepatocyte<br>Notch response in NASH-associated liver fibrosis.
DOI: 10.25376/hra.7795523
title: On the effect of hyperaldosteronism-inducing mutation in Na/K pumps

description: Primary aldosteronism, a condition in which too much aldosterone is produced and that leads to hypertension, is often initiated by an aldosterone-producing adenoma within the zona glomerulosa of the adrenal cortex. Somatic mutations of ATP1A1, encoding the Na/K pump α1 subunit, have been found in these adenomas. It has been proposed that a passive inward current transported by several of these mutant pumps is a "gain-of-function" activity that produces membrane depolarization and concomitant increases in aldosterone production. Here, we investigate whether the inward current through mutant Na/K pumps is large enough to induce depolarization of the cells that harbor them. We first investigate inward currents induced by these mutations in <i>Xenopus</i> Na/K pumps expressed in <i>Xenopus</i> oocytes and find that these inward currents are similar in amplitude to wild-type outward Na/K pump currents. Subsequently, we perform a detailed functional evaluation of the human Na/K pump mutants L104R, delF100-L104, V332G, and EETA963S expressed in <i>Xenopus</i> oocytes. By combining two-electrode voltage clamp with [3H]ouabain binding, we measure the turnover rate of these inward currents and compare it to the turnover rate for outward current through wild-type pumps. We find that the turnover rate of the inward current through two of these mutants (EETA963S and L104R) is too small to induce significant cell depolarization. Electrophysiological characterization of another hyperaldosteronism-inducing mutation, G99R, reveals the absence of inward currents under many different conditions, including in the presence of the regulator FXYD1 as well as with mammalian ionic concentrations and body temperatures. Instead, we observe robust outward currents, but with significantly reduced affinities for intracellular Na+ and extracellular K+ Collectively, our results point to loss-of-function as the common mechanism for the hyperaldosteronism induced by these Na/K pump mutants.
DOI: 10.25376/hra.7795523.v1
title: On the effect of hyperaldosteronism-inducing mutation in Na/K pumps

description: Primary aldosteronism, a condition in which too much aldosterone is produced and that leads to hypertension, is often initiated by an aldosterone-producing adenoma within the zona glomerulosa of the adrenal cortex. Somatic mutations of ATP1A1, encoding the Na/K pump α1 subunit, have been found in these adenomas. It has been proposed that a passive inward current transported by several of these mutant pumps is a "gain-of-function" activity that produces membrane depolarization and concomitant increases in aldosterone production. Here, we investigate whether the inward current through mutant Na/K pumps is large enough to induce depolarization of the cells that harbor them. We first investigate inward currents induced by these mutations in <i>Xenopus</i> Na/K pumps expressed in <i>Xenopus</i> oocytes and find that these inward currents are similar in amplitude to wild-type outward Na/K pump currents. Subsequently, we perform a detailed functional evaluation of the human Na/K pump mutants L104R, delF100-L104, V332G, and EETA963S expressed in <i>Xenopus</i> oocytes. By combining two-electrode voltage clamp with [3H]ouabain binding, we measure the turnover rate of these inward currents and compare it to the turnover rate for outward current through wild-type pumps. We find that the turnover rate of the inward current through two of these mutants (EETA963S and L104R) is too small to induce significant cell depolarization. Electrophysiological characterization of another hyperaldosteronism-inducing mutation, G99R, reveals the absence of inward currents under many different conditions, including in the presence of the regulator FXYD1 as well as with mammalian ionic concentrations and body temperatures. Instead, we observe robust outward currents, but with significantly reduced affinities for intracellular Na+ and extracellular K+ Collectively, our results point to loss-of-function as the common mechanism for the hyperaldosteronism induced by these Na/K pump mutants.
DOI: 10.25376/hra.7795592.v2
title: aat0344_Combined version.pdf

description: Fibrosis is the major determinant of morbidity and mortality in patients with nonalcoholic steatohepatitis (NASH)<br>but has no approved pharmacotherapy in part because of incomplete understanding of its pathogenic mechanisms.<br>Here, we report that hepatocyte Notch activity tracks with disease severity and treatment response in patients with<br>NASH and is similarly increased in a mouse model of diet-induced NASH and liver fibrosis. Hepatocyte-specific<br>Notch loss-of-function mouse models showed attenuated NASH-associated liver fibrosis, demonstrating causality<br>to obesity-induced liver pathology. Conversely, forced activation of hepatocyte Notch induced fibrosis in both<br>chow- and NASH diet–fed mice by increasing Sox9-dependent Osteopontin (Opn) expression and secretion from hepatocytes, which activate resident hepatic stellate cells. In a cross-sectional study, we found that OPN explains<br>the positive correlation between liver Notch activity and fibrosis stage in patients. Further, we developed a Notch<br>inhibitor [Nicastrin antisense oligonucleotide (Ncst ASO)] that reduced fibrosis in NASH diet–fed mice. In summary,<br>these studies demonstrate the pathological role and therapeutic accessibility of the maladaptive hepatocyte<br>Notch response in NASH-associated liver fibrosis.
DOI: 10.25376/hra.7795463
title: Hyperinsulinemia augments endothelin‐1 protein expression and impairs vasodilation of human skeletal muscle arterioles.pdf

description: Hyperinsulinemia impaired flow induced dilation by disturbing the balance between vasodilators such as nitric oxide and vasoconstrictors such as endothelin 1
DOI: 10.25376/hra.7795466
title: Role of matrix metalloproteinases and histone deacetylase in oxidative stress-induced degradation of the endothelial glycocalyx.pdf

description: Oxidative stress induces HDAC activity and MMP activity leading to loss of endothelial glycocalyx<br>
DOI: 10.25376/hra.7795466.v1
title: Role of matrix metalloproteinases and histone deacetylase in oxidative stress-induced degradation of the endothelial glycocalyx.pdf

description: Oxidative stress induces HDAC activity and MMP activity leading to loss of endothelial glycocalyx<br>
DOI: 10.17866/rd.salford.7795571.v1
title: 2019 PaR Guidance Documents

description: In these guidance documents, you'll find advice for how to put together your Figshare portfolio for REF purposes and how to let USIR know your portfolio is ready for peer review, advice on best practice for peer-reviewing PaR and a guidance rubric for doing so, and latest news about PaR from REF, PRAG and other official bodies/consultations.
DOI: 10.25376/hra.7795463.v1
title: Hyperinsulinemia augments endothelin‐1 protein expression and impairs vasodilation of human skeletal muscle arterioles.pdf

description: Hyperinsulinemia impaired flow induced dilation by disturbing the balance between vasodilators such as nitric oxide and vasoconstrictors such as endothelin 1
DOI: 10.25376/hra.7795457
title: Microvascular Vasodilator Plasticity After Acute Exercise.pdf

description: This review outlines the normal mechanisms of vasodilation and data supporting the novel observation that H2O2 serves as a compensatory vasodilator to maintain vasodilation after acute resistance exercise and exposure to high intraluminal pressure in arterioles from regular exercisers.
DOI: 10.25376/hra.7795460
title: Nox2 contributes to hyperinsulinemia-induced redox imbalance and impaired vascular function.pdf

description: Hyperinsulinemia impaired vasodilation and nitric oxide bioavailability via inducing NADPH oxidase activity and oxidative stress
DOI: 10.17866/rd.salford.7795571.v2
title: 2019 PaR Guidance Documents

description: In these guidance documents, you'll find advice for how to put together your Figshare portfolio for REF purposes and how to let USIR know your portfolio is ready for peer review, advice on best practice for peer-reviewing PaR and a guidance rubric for doing so, and latest news about PaR from REF, PRAG and other official bodies/consultations.
DOI: 10.25376/hra.7795457.v1
title: Microvascular Vasodilator Plasticity After Acute Exercise.pdf

description: This review outlines the normal mechanisms of vasodilation and data supporting the novel observation that H2O2 serves as a compensatory vasodilator to maintain vasodilation after acute resistance exercise and exposure to high intraluminal pressure in arterioles from regular exercisers.
DOI: 10.25376/hra.7795460.v1
title: Nox2 contributes to hyperinsulinemia-induced redox imbalance and impaired vascular function.pdf

description: Hyperinsulinemia impaired vasodilation and nitric oxide bioavailability via inducing NADPH oxidase activity and oxidative stress
DOI: 10.6084/m9.figshare.7795454
title: Electronic Supplementary Material

description: Electronic Supplementary Material
DOI: 10.17866/rd.salford.7795571.v3
title: 2019 PaR Guidance Documents

description: In these guidance documents, you'll find advice for how to put together your Figshare portfolio for REF purposes and how to let USIR know your portfolio is ready for peer review, advice on best practice for peer-reviewing PaR and a guidance rubric for doing so, and latest news about PaR from REF, PRAG and other official bodies/consultations.
DOI: 10.6084/m9.figshare.7795454.v1
title: Daucus carota data

description: Daucus carota whole genome SSR markers.
DOI: 10.6084/m9.figshare.7795454.v2
title: Electronic Supplementary Material

description: Electronic Supplementary Material
DOI: 10.6084/m9.figshare.7795190
title: Raw data.rar

description: A new genus with a new species of the tribe Hoplocampini of Hoplocampinae is described from China
DOI: 10.6084/m9.figshare.7795190.v1
title: Raw data.rar

description: A new genus with a new species of the tribe Hoplocampini of Hoplocampinae is described from China
DOI: 10.6084/m9.figshare.7795100
title: Supporting materials

description: Supporting materials
DOI: 10.6084/m9.figshare.7795070
title: Additional file 9.zip

description: CLEAN files
DOI: 10.6084/m9.figshare.7795070.v1
title: Additional file 9.zip

description: CLEAN files
DOI: 10.6084/m9.figshare.7795100.v1
title: Supporting materials

description: Supporting materials
DOI: 10.6084/m9.figshare.7794761
title: Additional file 3: of Oxygen induces the expression of invasion and stress response genes in the anaerobic salmon parasite Spironucleus salmonicida

description: Bioinformatic summary of protein domain architecture, predicted transmembrane domains and subcellular localization for the three sets of hypothetical proteins reported in Additional file 2: Figure S1. (XLSX 923 kb)
DOI: 10.6084/m9.figshare.7794761.v1
title: Additional file 3: of Oxygen induces the expression of invasion and stress response genes in the anaerobic salmon parasite Spironucleus salmonicida

description: Bioinformatic summary of protein domain architecture, predicted transmembrane domains and subcellular localization for the three sets of hypothetical proteins reported in Additional file 2: Figure S1. (XLSX 923 kb)
DOI: 10.6084/m9.figshare.7794746
title: Additional file 1: of Oxygen induces the expression of invasion and stress response genes in the anaerobic salmon parasite Spironucleus salmonicida

description: Read mapping statistics, gene expression information, and primer sequences. See file for details. (XLSX 2535 kb)
DOI: 10.6084/m9.figshare.7794746.v1
title: Additional file 1: of Oxygen induces the expression of invasion and stress response genes in the anaerobic salmon parasite Spironucleus salmonicida

description: Read mapping statistics, gene expression information, and primer sequences. See file for details. (XLSX 2535 kb)
DOI: 10.6084/m9.figshare.7794719
title: Additional file 4: of Conditional cash transfers to retain rural Kenyan women in the continuum of care during pregnancy, birth and the postnatal period: protocol for a cluster randomized controlled trial

description: AnnexÂ 13a: Informed consent form, English. AnnexÂ 14a: Consent to access medical records, English. (ZIP 23 kb)
DOI: 10.6084/m9.figshare.7794719.v1
title: Additional file 4: of Conditional cash transfers to retain rural Kenyan women in the continuum of care during pregnancy, birth and the postnatal period: protocol for a cluster randomized controlled trial

description: AnnexÂ 13a: Informed consent form, English. AnnexÂ 14a: Consent to access medical records, English. (ZIP 23 kb)
DOI: 10.6084/m9.figshare.7794686
title: Additional file 5: of An intergenerational program based on psycho-motor activity promotes well-being and interaction between preschool children and older adults: results of a process and outcome evaluation study in Austria

description: Quantitative dataset provided in an anonymized form. (XLSX 42 kb)
DOI: 10.6084/m9.figshare.7794686.v1
title: Additional file 5: of An intergenerational program based on psycho-motor activity promotes well-being and interaction between preschool children and older adults: results of a process and outcome evaluation study in Austria

description: Quantitative dataset provided in an anonymized form. (XLSX 42 kb)
DOI: 10.6084/m9.figshare.7794485
title: Rate of land-use change (RLUC) index

description: The RLUC in­dex represents the rate of land-use change from pri­mary and sec­ondary veg­e­ta­tion to three anthropogenic land-use types (crop­land, pas­ture, and ur­ban land) every ten years from 1500 to 2010 across a 0.25° x 0.25° grid while also ac­count­ing for dif­fer­en­tial impacts on bio­di­ver­sity on the ba­sis of the type of land-use change. <br>
DOI: 10.6084/m9.figshare.7794317
title: MonocularVision-Datasets.xlsx

description: Experimental datasets (group1-8) of monocular vision.
DOI: 10.6084/m9.figshare.7794305
title: fichamento da disciplina Representação Temática da Informação Arquivística II

description: <b>o documento é um livro do livro: uma apresentação e uma apresentação de uma série de funções. apresentando como principais ideias.</b><b>e com uma visão do autor.</b><b>é apenas um fichamento simples sem muito aprofundamento.</b><br><br><br><br><br>
DOI: 10.6084/m9.figshare.7794317.v1
title: MonocularVision-Datasets.xlsx

description: Experimental datasets (group1-8) of monocular vision.
DOI: 10.6084/m9.figshare.7794317.v2
title: MonocularVision-Datasets.xlsx

description: Experimental datasets (group1-8) of monocular vision.
DOI: 10.6084/m9.figshare.7794296
title: silva_nr_v132_train_set.fa_dada2.gz

description: Silva
DOI: 10.6084/m9.figshare.7794305.v1
title: fichamento da disciplina Representação Temática da Informação Arquivística II

description: <b>o documento é um livro do livro: uma apresentação e uma apresentação de uma série de funções. apresentando como principais ideias.</b><b>e com uma visão do autor.</b><b>é apenas um fichamento simples sem muito aprofundamento.</b><br><br><br><br><br>
DOI: 10.6084/m9.figshare.7794302
title: online material for paper Machine Vision in the Context of Robotics: a Mapping Study

description: This papers are found based on our literature study <br>
DOI: 10.6084/m9.figshare.7794302.v1
title: online material for paper Machine Vision in the Context of Robotics: a Mapping Study

description: This papers are found based on our literature study <br>
DOI: 10.6084/m9.figshare.7794131
title: Predation risk of mate searching in crickets

description: We estimated relative predation risk experienced in natural populations of male and female crickets that were communicating and not communicating. We did this by quantifying predation risk as a probability of mortality in the context of acoustic communication in a tree cricket, <i>Oecanthus henryi</i> from its ecologically relevant predator, a lynx spider, <i>Peucetia viridans</i>. Probability of mortality was quantified by partitioning it into three spatial components at which these crickets and spiders interact, using a combination of extensive field observations and manipulative experiments in a semi-natural setup. These data are a binary response of prey either succeeding (1) or failing (0) to avoid the predator at each spatial scale. Predation risk was estimated as a product of these probabilities.
DOI: 10.6084/m9.figshare.7794119
title: Acosta.etal.Feb2019 Transcriptome from Basiliscus vittatus

description: Transcriptome reconstruction made with Trinity (v2.0.2, default k-mer of 25 bp) (Grabherr, Haas et al. 2011) from RNAseq data from brain, heart, kidney, liver, blood, and gonads from 1 male and 1 female individuals of Basiliscus vittatus.
DOI: 10.6084/m9.figshare.7794107
title: Acosta.etal.Feb2019 Y-linked transcripts from Basiliscus vittatus

description: Y-linked transcripts from Basiliscus vittatus
DOI: 10.6084/m9.figshare.7794119.v1
title: Acosta.etal.Feb2019 Transcriptome from Basiliscus vittatus

description: Transcriptome reconstruction made with Trinity (v2.0.2, default k-mer of 25 bp) (Grabherr, Haas et al. 2011) from RNAseq data from brain, heart, kidney, liver, blood, and gonads from 1 male and 1 female individuals of Basiliscus vittatus.
DOI: 10.6084/m9.figshare.7794107.v1
title: Acosta.etal.Feb2019 Y-linked transcripts from Basiliscus vittatus

description: Y-linked transcripts from Basiliscus vittatus
DOI: 10.6084/m9.figshare.7794011
title: Experimental observations of 3D flow alterations by vegetation under oscillatory flows

description: Data presented and discussed on "Experimental observations of 3D flow alterations by vegetation under oscillatory flows", by Jorge San Juan, Gerardo Veliz, and Rafael O. Tinoco, published in Environmental Fluid Mechanics, DOI : 10.1007/s10652-019-09672-2. Data files are described in detail in the ReadMe File.<br>
DOI: 10.6084/m9.figshare.7793930
title: Swamputational Biology Seminar

description: Talk delivered at LSU 2.27.2019. Video here: https://www.youtube.com/watch?v=dRULJHRl_OU&list=PLV8dyTG7O7VaAdUsW791_yOxE51aFHCmY&index=14&t=0s<br>
DOI: 10.6084/m9.figshare.7793930.v1
title: Swamputational Biology Seminar

description: Talk delivered at LSU 2.27.2019. Video here: https://www.youtube.com/watch?v=dRULJHRl_OU&list=PLV8dyTG7O7VaAdUsW791_yOxE51aFHCmY&index=14&t=0s<br>
DOI: 10.6084/m9.figshare.7793888
title: Convolutional neural network for cell classification using microscope images of intracellular actin networks

description: The immunofluorescence confocal microscopy images of three different cell lines: MCF-10A, MCF-7 and MDA-MB-231 with F-actin stained.<br>
DOI: 10.6084/m9.figshare.7793807
title: Fasting Values of Glucose, NEFA, Insulin, C-Peptide, and Glucagon During Sleep Restriction

description: Fasting Values of Glucose, Insulin, C-Peptide, NEFA, and Glucagon by Condition. Values are reported as mean (SD) for fasting time points (minutes -15 through 0). Fasting c-peptide was significantly suppressed by sleep restriction (p = 0.05) and the recovery condition (p = 0.02) compared to baseline.
DOI: 10.6084/m9.figshare.7793888.v2
title: Convolutional neural network for cell classification using microscope images of intracellular actin networks

description: The immunofluorescence confocal microscopy images of three different cell lines: MCF-10A, MCF-7 and MDA-MB-231 with F-actin stained.<br>
DOI: 10.6084/m9.figshare.7793888.v1
title: Convolutional neural network for cell classification using microscope images of intracellular actin networks

description: The immunofluorescence confocal microscopy images of three different cell lines: MCF-10A, MCF-7 and MDA-MB-231 with F-actin stained.<br>
DOI: 10.1184/r1/7792505
title: Data Sets and Analysis Results Accompanying a Dictionary Indexing Tutorial Paper

description: These file sets accompany a tutorial paper that has been submitted to the journal "Integrating Materials and Manufacturing Innovation". There are three main files (tar.gz) that each contain many files, including experimental data sets, input files for analysis programs, and results files produced by the EMsoft open source package for electron microscopy simulations. In addition, there is a small file that contains input crystal structure data, as well as a Supplementary Materials PDF file that provides additional information for whomever wants to try out the dictionary indexing approach using our open data sets.
DOI: 10.1184/r1/7792505.v1
title: Data Sets and Analysis Results Accompanying a Dictionary Indexing Tutorial Paper

description: These file sets accompany a tutorial paper that has been submitted to the journal "Integrating Materials and Manufacturing Innovation". There are three main files (tar.gz) that each contain many files, including experimental data sets, input files for analysis programs, and results files produced by the EMsoft open source package for electron microscopy simulations. In addition, there is a small file that contains input crystal structure data, as well as a Supplementary Materials PDF file that provides additional information for whomever wants to try out the dictionary indexing approach using our open data sets.