cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.7806743
title: 2019 World Kidney Day Editorial - burden, access, and disparities in kidney disease

description: Abstract Kidney disease is a global public health problem, affecting over 750 million persons worldwide. The burden of kidney disease varies substantially across the world, as does its detection and treatment. In many settings, rates of kidney disease and the provision of its care are defined by socio-economic, cultural, and political factors leading to significant disparities. World Kidney Day 2019 offers an opportunity to raise awareness of kidney disease and highlight disparities in its burden and current state of global capacity for prevention and management. Here, we highlight that many countries still lack access to basic diagnostics, a trained nephrology workforce, universal access to primary health care, and renal replacement therapies. We point to the need for strengthening basic infrastructure for kidney care services for early detection and management of acute kidney injury and chronic kidney disease across all countries and advocate for more pragmatic approaches to providing renal replacement therapies. Achieving universal health coverage worldwide by 2030 is one of the World Health Organization's Sustainable Development Goals. While universal health coverage may not include all elements of kidney care in all countries, understanding what is feasible and important for a country or region with a focus on reducing the burden and consequences of kidney disease would be an important step towards achieving kidney health equity.
DOI: 10.6084/m9.figshare.7806743.v1
title: 2019 World Kidney Day Editorial - burden, access, and disparities in kidney disease

description: Abstract Kidney disease is a global public health problem, affecting over 750 million persons worldwide. The burden of kidney disease varies substantially across the world, as does its detection and treatment. In many settings, rates of kidney disease and the provision of its care are defined by socio-economic, cultural, and political factors leading to significant disparities. World Kidney Day 2019 offers an opportunity to raise awareness of kidney disease and highlight disparities in its burden and current state of global capacity for prevention and management. Here, we highlight that many countries still lack access to basic diagnostics, a trained nephrology workforce, universal access to primary health care, and renal replacement therapies. We point to the need for strengthening basic infrastructure for kidney care services for early detection and management of acute kidney injury and chronic kidney disease across all countries and advocate for more pragmatic approaches to providing renal replacement therapies. Achieving universal health coverage worldwide by 2030 is one of the World Health Organization's Sustainable Development Goals. While universal health coverage may not include all elements of kidney care in all countries, understanding what is feasible and important for a country or region with a focus on reducing the burden and consequences of kidney disease would be an important step towards achieving kidney health equity.
DOI: 10.6084/m9.figshare.7806737
title: Rootstock-scion interaction: 4. Effect on the sensory characteristics of Cabernet Sauvignon wine

description: Abstract It is known that rootstock can induce changes on grapevine yield components and on the physicochemical composition of musts and wines. However, its effect on the sensory characteristics of wines has been scarcely studied. For this reason, an experiment was conducted to determine the effect of 15 rootstocks on the sensory characteristics of Cabernet Sauvignon wine, whose grapevines were grafted on Rupestris du Lot, 101-14 Mgt, 3309 C, 420A Mgt, 5BB K, 161-49 C, SO4, Solferino, 1103 P, 99 R, 110 R, Gravesac, Fercal, Dogridge and Isabel, which feature some genetic diversity altogether. The experimental design was in randomized blocks, with 15 treatments, three replicates, 10 vines per plot. Mature grapes were harvested, and wines were made in 20-L glass recipients. When alcoholic and malolactic fermentations were finished, the wines were bottled and stored at 18°C. Sensory analysis was performed in the next year, following international procedures. The tasting panel was formed by 12 experienced enologists, who evaluated the wines in individual cells separated by opaque glass. They were served monadically and the perception of each taster was recorded in 9-cm unstructured scale sheets. Twenty-two variables were evaluated, which were related to the visual, olfactory and taste aspects. The results show that the tasting panel was not able to detect significant differences (p&gt; 0.05) of rootstocks in any variable related to the sensory characteristics of Cabernet Sauvignon wine.
DOI: 10.6084/m9.figshare.7806740
title: Challenges in high-sensitive troponin assay interpretation for intensive therapy

description: ABSTRACT Cardiac troponins T and I are considered highly sensitive and specific markers for the diagnosis of acute myocardial infarction. Currently, a series of nonprimary cardiac abnormalities may manifest as an elevation in high-sensitive assays. The reduction in their detection limits has allowed earlier diagnosis and the use of evidence-based therapeutic measures; however, this characteristic has increased the spectrum of detectable noncoronary heart diseases, which poses challenges for characterizing acute coronary syndromes and creates a new role for these tests in known disorders in intensive care units, especially sepsis. Management of patients through a greater understanding of how these markers behave should be re-evaluated to ensure their correct interpretation.
DOI: 10.6084/m9.figshare.7806734
title: Sociedade Portuguesa de Cuidados Intensivos guidelines for stress ulcer prophylaxis in the intensive care unit

description: ABSTRACT Critically ill patients are at risk of developing stress ulcers in the upper digestive tract. Agents that suppress gastric acid are commonly prescribed to reduce the incidence of clinically important stress ulcer-related gastrointestinal bleeding. However, the indiscriminate use of stress ulcer prophylaxis in all patients admitted to the intensive care unit is not warranted and can have potential adverse clinical effects and cost implications. The present guidelines from the Sociedade Portuguesa de Cuidados Intensivos summarizes the current evidence and gives six clinical statements and an algorithm aiming to provide a standardized prescribing policy for the use of stress ulcer prophylaxis in the intensive care unit.
DOI: 10.6084/m9.figshare.7806740.v1
title: Challenges in high-sensitive troponin assay interpretation for intensive therapy

description: ABSTRACT Cardiac troponins T and I are considered highly sensitive and specific markers for the diagnosis of acute myocardial infarction. Currently, a series of nonprimary cardiac abnormalities may manifest as an elevation in high-sensitive assays. The reduction in their detection limits has allowed earlier diagnosis and the use of evidence-based therapeutic measures; however, this characteristic has increased the spectrum of detectable noncoronary heart diseases, which poses challenges for characterizing acute coronary syndromes and creates a new role for these tests in known disorders in intensive care units, especially sepsis. Management of patients through a greater understanding of how these markers behave should be re-evaluated to ensure their correct interpretation.
DOI: 10.6084/m9.figshare.7806746.v1
title: Rootstock-scion interaction:3. Effect on the composition of Cabernet Sauvignon wine

description: Abstract The interaction among rootstock, scion and environment may induce different responses to the grapevine physiology and consequently to the grape and wine composition. The vineyards of Serra Gaúcha, Brazil, are established in soils that may have different physicochemical attributes. Furthermore, the grapevines are grafted on a wide diversity of rootstocks. Therefore, this study aimed to determine their effect on the wine composition of the Cabernet Sauvignon (CS) grafted on Rupestris du Lot, 101-14 Mgt, 3309 C, 420A Mgt, 5BB K, 161-49 C, SO4, Solferino, 1103 P, 99 R, 110 R, Gravesac, Fercal, Dogridge and Isabel, featuring some genetic diversity altogether. The experimental design was in randomized blocks, with 15 treatments, three replicates and 10 vines per plot. The grapes were harvested at maturity for three years, and then wines were made in glass recipients of 20 L. When alcoholic and malolactic fermentations were over, the wine analyses were performed on twenty-five variables related to alcohol, acidity, dry extract, polyphenols and volatile compounds. The main results show that all variables were affected year by year, some of them by the rootstock and a few by the interaction between rootstock and year. The rootstock effect was observed mainly on variables related to alcohol, acidity and ashes. Results show that the CS/101-14 Mgt wine had higher alcohol content than CS/Dogridge and CS/Isabel wines, which was probably due to the 101-14 Mgt rootstock favoring an early grape ripening. However, higher pH values were observed in the CS/Rupestris du Lot, CS/5BB K and CS/Gravesac than CS/420A Mgt, CS/110 R and CS/Isabel wines. These results show that there is a diversity of rootstocks that can be used by the growers due to the Cabernet Sauvignon wine composition similarities.
DOI: 10.6084/m9.figshare.7806728
title: Adverse events during intrahospital transport of critically ill patients in a large hospital

description: ABSTRACT Objective: To describe the incidence of clinical and non-clinical events during intrahospital transport of critically ill patients and to analyze the associated risk factors. Methods: Cohort study with retrospective data collected from October 2016 to October 2017. All cases of intrahospital transport for diagnostic and therapeutic purposes in a large hospital with six adult intensive care units were analyzed, and the adverse events and related risk factors were evaluated. Results: During the study period, 1,559 intrahospital transports were performed with 1,348 patients, with a mean age of 66 ± 17 years and a mean transport time of 43 ± 34 minutes. During transport, 19.8% of the patients were using vasoactive drugs; 13.7% were under sedation; and 10.6% were under mechanical ventilation. Clinical events occurred in 117 transports (7.5%), and non-clinical events occurred in 125 (8.0%) transports. Communication failures were prevalent; however, the multivariate analysis showed that the use of sedatives, noradrenaline and nitroprusside and a transport time greater than 36.5 minutes were associated with adverse clinical events. The use of dobutamine and a transport time greater than 36.5 minutes were associated with non-clinical events. At the end of transport, 98.1% of the patients presented unchanged clinical conditions compared with baseline. Conclusion: Intrahospital transport is related to a high incidence of adverse events, and transport time and the use of sedatives and vasoactive drugs were related to these events.
DOI: 10.6084/m9.figshare.7806728.v1
title: Adverse events during intrahospital transport of critically ill patients in a large hospital

description: ABSTRACT Objective: To describe the incidence of clinical and non-clinical events during intrahospital transport of critically ill patients and to analyze the associated risk factors. Methods: Cohort study with retrospective data collected from October 2016 to October 2017. All cases of intrahospital transport for diagnostic and therapeutic purposes in a large hospital with six adult intensive care units were analyzed, and the adverse events and related risk factors were evaluated. Results: During the study period, 1,559 intrahospital transports were performed with 1,348 patients, with a mean age of 66 ± 17 years and a mean transport time of 43 ± 34 minutes. During transport, 19.8% of the patients were using vasoactive drugs; 13.7% were under sedation; and 10.6% were under mechanical ventilation. Clinical events occurred in 117 transports (7.5%), and non-clinical events occurred in 125 (8.0%) transports. Communication failures were prevalent; however, the multivariate analysis showed that the use of sedatives, noradrenaline and nitroprusside and a transport time greater than 36.5 minutes were associated with adverse clinical events. The use of dobutamine and a transport time greater than 36.5 minutes were associated with non-clinical events. At the end of transport, 98.1% of the patients presented unchanged clinical conditions compared with baseline. Conclusion: Intrahospital transport is related to a high incidence of adverse events, and transport time and the use of sedatives and vasoactive drugs were related to these events.
DOI: 10.6084/m9.figshare.7806734.v1
title: Sociedade Portuguesa de Cuidados Intensivos guidelines for stress ulcer prophylaxis in the intensive care unit

description: ABSTRACT Critically ill patients are at risk of developing stress ulcers in the upper digestive tract. Agents that suppress gastric acid are commonly prescribed to reduce the incidence of clinically important stress ulcer-related gastrointestinal bleeding. However, the indiscriminate use of stress ulcer prophylaxis in all patients admitted to the intensive care unit is not warranted and can have potential adverse clinical effects and cost implications. The present guidelines from the Sociedade Portuguesa de Cuidados Intensivos summarizes the current evidence and gives six clinical statements and an algorithm aiming to provide a standardized prescribing policy for the use of stress ulcer prophylaxis in the intensive care unit.
DOI: 10.6084/m9.figshare.7806737.v1
title: Rootstock-scion interaction: 4. Effect on the sensory characteristics of Cabernet Sauvignon wine

description: Abstract It is known that rootstock can induce changes on grapevine yield components and on the physicochemical composition of musts and wines. However, its effect on the sensory characteristics of wines has been scarcely studied. For this reason, an experiment was conducted to determine the effect of 15 rootstocks on the sensory characteristics of Cabernet Sauvignon wine, whose grapevines were grafted on Rupestris du Lot, 101-14 Mgt, 3309 C, 420A Mgt, 5BB K, 161-49 C, SO4, Solferino, 1103 P, 99 R, 110 R, Gravesac, Fercal, Dogridge and Isabel, which feature some genetic diversity altogether. The experimental design was in randomized blocks, with 15 treatments, three replicates, 10 vines per plot. Mature grapes were harvested, and wines were made in 20-L glass recipients. When alcoholic and malolactic fermentations were finished, the wines were bottled and stored at 18°C. Sensory analysis was performed in the next year, following international procedures. The tasting panel was formed by 12 experienced enologists, who evaluated the wines in individual cells separated by opaque glass. They were served monadically and the perception of each taster was recorded in 9-cm unstructured scale sheets. Twenty-two variables were evaluated, which were related to the visual, olfactory and taste aspects. The results show that the tasting panel was not able to detect significant differences (p&gt; 0.05) of rootstocks in any variable related to the sensory characteristics of Cabernet Sauvignon wine.
DOI: 10.6084/m9.figshare.7806716
title: Using climate change models to assess the probability of weather extremes events: a local scale study based on the generalized extreme value distribution

description: ABSTRACT Regional climate models (e.g. Eta) nested to global climate models (e.g. HadGEM2-ES and MIROC5) have been used to assess potential impacts of climate change at regional scales. This study used the generalized extreme value distribution (GEV) to evaluate the ability of two nested models (Eta-HadGEM2-ES and Eta-MIROC5) to assess the probability of daily extremes of air temperature and precipitation in the location of Campinas, state of São Paulo, Brazil. Within a control run (1961-2005), correction factors based on the GEV parameters have been proposed to approach the distributions generated from the models to those built from the weather station of Campinas. Both models were also used to estimate the probability of daily extremes of air temperature (maximum and minimum) and precipitation for the 2041-2070 period. Two concentration paths of greenhouse gases (RCP 4.5 and 8.5) have been considered. Although both models project changes to warmer conditions, the responses of Eta-Hadgem2-ES to both RCPs are significantly larger than that of Eta-Miroc5. While Eta-Hadgem2-ES suggests the location of Campinas will be free from agronomic frost events, Eta-Miroc5 indicates that air temperature values equal to or lower than 5 and 2 °C are expected to present a cumulative probabilityof ~0.20 and ~0.05, respectively (RCP 8.5). Moreover, while the Eta-Miroc5 projected a reduction in the extreme-precipitation amounts, the Eta-Hadgem2-ES projected implausible large daily precipitation amounts. The Eta-Miroc5 performed better than the Eta-Hadgem2-ES for assessing the probability of air temperature and precipitation in Campinas. This latter statement holds particularly true for daily-extreme precipitation data.
DOI: 10.6084/m9.figshare.7806722
title: Evaluation of common bean genotypes for drought tolerance

description: ABSTRACT The aim of this study was to evaluate twelve genotypes of common bean for intermittent drought stress and for root growth angle. The water deficit experiments were conducted in 2015 and 2016in a randomized block experimental design with split plots and three replications. Two treatments were applied: an irrigated treatment and a water deficit treatment, in which irrigation was suspended in pre-flowering and remained suspended up to the time at which the matrix potential of the soil was measured to be near –199 kPa. Atthe maximum point of water deficit, physiological and morphological traits were evaluated, and at physiological maturity, the yield compounds and grain yield. To evaluate root growth angle in 2016, a growth pouch system was used in a randomized block design, with five replications. Water deficit reduced genotype performance for all the traits except leaf temperature and first pod height. In relation to grain yield, the genotypes SEA 5 and Carioca Precoce performed better under water restriction conditions in both evaluations. The genotype Gen TS 4-7 performed better in the 2015 evaluation, and Gen TS 3-1 andGen TS 3-3 in 2016. SEA 5, Gen TS 3-1, and Carioca Precoce had the highest harvest indexes in 2015; and Gen TS 3-1, Gen TS 3-2,Gen TS 3-3, Gen P5-4-3-1, IAPAR 81, Carioca Precoce, and SEA 5 in 2016. SEA 5 and Carioca Precoce had the best root growth angle and were considered sources of tolerance to water deficit.
DOI: 10.6084/m9.figshare.7806725
title: ‘SCS425 Luiza’: new apple cultivar with medium chilling requirement and resistant to glomerella leaf spot (colletotrichum spp.)

description: Abstract Apple is one of the main agribusiness products of temperate-zone fruits in Southern Brazil. More than 90% of apple production is obtained from only two apple cultivars – Gala and Fuji and their mutations. These apple varieties are insufficiently adapted to the regional climate and ‘Gala’ and its mutations are also susceptible to glomerella leaf spot – GLS, currently the main apple disease in Brazil. ‘SCS425 Luiza’ cultivar was developed by Epagri / Estação Experimental Caçador, aiming to offer to the production chain an early apple variety better adapted to the environmental conditions of Southern Brazil and resistant to GLS. ‘SCS425 Luiza’ cultivar was obtained by artificial hybridization carried out in 2001 using the cultivars Imperatriz and Cripps Pink as parents. ‘SCS425 Luiza’ has lower chilling requirement compared to ‘Galaxy’, higher flowering precocity and yield potential at least equivalent to ‘Galaxy’. It produces fruits with skin finish, flavor and flesh texture adequate for the Brazilian market and storability similar to ‘Galaxy’ apples when harvested at the same maturity.
DOI: 10.6084/m9.figshare.7806716.v1
title: Using climate change models to assess the probability of weather extremes events: a local scale study based on the generalized extreme value distribution

description: ABSTRACT Regional climate models (e.g. Eta) nested to global climate models (e.g. HadGEM2-ES and MIROC5) have been used to assess potential impacts of climate change at regional scales. This study used the generalized extreme value distribution (GEV) to evaluate the ability of two nested models (Eta-HadGEM2-ES and Eta-MIROC5) to assess the probability of daily extremes of air temperature and precipitation in the location of Campinas, state of São Paulo, Brazil. Within a control run (1961-2005), correction factors based on the GEV parameters have been proposed to approach the distributions generated from the models to those built from the weather station of Campinas. Both models were also used to estimate the probability of daily extremes of air temperature (maximum and minimum) and precipitation for the 2041-2070 period. Two concentration paths of greenhouse gases (RCP 4.5 and 8.5) have been considered. Although both models project changes to warmer conditions, the responses of Eta-Hadgem2-ES to both RCPs are significantly larger than that of Eta-Miroc5. While Eta-Hadgem2-ES suggests the location of Campinas will be free from agronomic frost events, Eta-Miroc5 indicates that air temperature values equal to or lower than 5 and 2 °C are expected to present a cumulative probabilityof ~0.20 and ~0.05, respectively (RCP 8.5). Moreover, while the Eta-Miroc5 projected a reduction in the extreme-precipitation amounts, the Eta-Hadgem2-ES projected implausible large daily precipitation amounts. The Eta-Miroc5 performed better than the Eta-Hadgem2-ES for assessing the probability of air temperature and precipitation in Campinas. This latter statement holds particularly true for daily-extreme precipitation data.
DOI: 10.6084/m9.figshare.7806719
title: Antioxidant activity of essential oils from condiment plants and their effect on lactic cultures and pathogenic bacteria

description: ABSTRACT: Studies about preservative and antioxidant activity of essential oils have been encouraged in recent years, given their importance to food industry. The aim of the current study was to evaluate the antioxidant properties and antimicrobial activity of essential oils deriving from Syzygium aromaticum, Cymbopogon citratus and Lippia alba against lactic and pathogenic bacteria responsible for food-borne diseases. Essential oil antibacterial activity was assessed through disc diffusion and macrodilution tests conducted in a mixed lactic culture of Lactobacillus delbrueckii subsp. bulgaricus and Streptococcus thermophilus (YF-L903) and of Escherichia coli (ATCC 8739), Staphylococcus aureus (ATCC 6538), Salmonella enterica (ATCC 6017) strains. Based on the chromatographic analysis results, the essential oils shown to be composed of eugenol (79.41%) which was the prevalent compound in S. aromaticum, geranial (31.89%), neral (24.52%) and β-myrcene (25.37%) in C. citratus, as well as of geranial (33.80%) and neral (25.63%) in L. alba. The observed antibacterial activity confirmed the dose-dependent effect of these three oils on all the assessed bacteria; there was halo inhibition at concentration 20μL mL-1. The essential oil of S. aromaticum presented better antioxidant activity, with IC50 equal to 5.76μg mL-1 and antioxidant activity index of 6.94, and it was considered strong (AAI&gt;2.0) in comparison to the other evaluated oils. This essential oil also presented excellent antioxidant activity at concentrations lower than the one required to inhibit lactic cultures. Based in this outcome, the essential oil from S. aromaticum can be used as preservative agent in processed food whose formulation presents lactic cultures.