cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.30797789.v1
title: Supplementary Material for: Allopurinol Use is Associated With Decreased Incidence of Hepatic Decompensation and Overall Mortality Among Individuals With Cirrhosis: a Propensity-matched Cohort Study

description: Background: Cirrhosis is associated with significant morbidity and mortality. Recent studies have highlighted the potential role of allopurinol in reducing the incidence of hepatic decompensation among individuals with cirrhosis. This study aims to evaluate the association of allopurinol use with the incidence of hepatic decompensation and overall mortality in patients with cirrhosis in a large, propensity-matched cohort. 
Methods: A retrospective cohort study of adults with cirrhosis was conducted using the national TriNetX database, with 1:1 propensity score matching. Allopurinol exposure was assessed in three categories compared to individuals with no allopurinol use: 100mg, 300mg, and exposure at any dose. The primary outcome was the incidence of overall hepatic decompensation. Secondary outcomes included the incidence of ascites, esophageal variceal bleeding, hepatic encephalopathy (HE), hepatorenal syndrome (HRS), spontaneous bacterial peritonitis (SBP), hepatocellular carcinoma (HCC), and overall mortality. The outcomes were assessed at 6, 12, and 18 months. Odds ratios (OR) with 95% confidence intervals (CI) were calculated.
Results: After propensity-score matching, 5,358 patients who received allopurinol were compared with 5,358 controls. Dose-specific analyses included two additional matched cohorts: 2,124 patients receiving 100 mg of allopurinol and their matched controls, and 1,020 patients receiving 300 mg of allopurinol and their matched controls. At 18 months, a statistically significantly lower incidence of hepatic decompensation was seen in the overall allopurinol exposure cohort (OR: 0.77; 95% CI: 0.70-0.84), the 100 mg cohort (OR: 0.66; 95% CI: 0.57 to 0.76), and 300 mg cohort (OR: 0.76, 95% CI: 0.62 to 0.94). Allopurinol exposure was associated with a decreased incidence of esophageal variceal bleeding (OR: 0.71 95% CI: 0.55 to 0.92), ascites (OR: 0.77 95% CI: 0.69 to 0.84), HE (OR: 0.76 95% CI: 0.63 to 0.92), SBP (OR: 0.61 95% CI: 0.46 to 0.80), and overall death (OR: 0.86 95%% CI: 0.77 to 0.96) compared to the control group. 
Conclusion: In a propensity-score matched analysis of a large national database, individuals with cirrhosis and allopurinol use had significantly lower risk of hepatic decompensation and overall mortality. These findings suggest that allopurinol may play a potential role in managing cirrhosis, and randomized clinical trials are needed to confirm these findings.
DOI: 10.3535/5xn-f61-zs3
title: Boloria Moore, 1900

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/pkq-l6y-vat
title: Xestia (Pachnobia) speciosa Hübner, 1813

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/3d8-j6a-e7l
title: Euphydryas Scudder, 1872

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/yg2-p9q-cmr
title: Apamea (Apamea) illyria Freyer, 1846

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/7tf-9vq-q39
title: Odontosia sieversii (Ménétriés, 1856)

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/dg1-qkk-650
title: Hypena proboscidalis (Linnaeus, 1758)

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.6084/m9.figshare.30797792
title: Supplementary Material for: Progressive metastatic cutaneous TFCP2::FUS fusion positive rhabdomyosarcoma: a case report

description: Introduction: Rhabdomyosarcoma (RMS) rarely exhibits the TFCP2::FUS gene fusion and even more rarely presents as multiple cutaneous lesions. 

Case Presentation: We describe the case of a 48-year-old man who presented with multiple cutaneous masses eroding through the skin as well as visceral metastases following two previous resections for cutaneous neoplasms. Histopathology showed spindle morphology and positive staining for keratins, desmin, MYOD1, and myogenin. Genetic sequencing showed a non-canonical TFCP2::FUS fusion that, in combination with the immunohistochemistry, was diagnostic of RMS. He was treated with vincristine, dactinomycin, and cyclophosphamide, followed by cabozantinib and pembrolizumab, and finally pembrolizumab and concurrent radiation therapy to the targetable lesions. He had a continual, rapid progression of disease and expired two months following radiation.

Conclusion: This case is notable because it presents a rare example of an aggressive, TFCP2::FUS gene fusion-positive RMS presenting with multiple cutaneous metastases, and highlights that this entity is highly resistant to multiple chemotherapies, immunotherapy, and radiation therapy.
DOI: 10.6084/m9.figshare.30797792.v1
title: Supplementary Material for: Progressive metastatic cutaneous TFCP2::FUS fusion positive rhabdomyosarcoma: a case report

description: Introduction: Rhabdomyosarcoma (RMS) rarely exhibits the TFCP2::FUS gene fusion and even more rarely presents as multiple cutaneous lesions. 

Case Presentation: We describe the case of a 48-year-old man who presented with multiple cutaneous masses eroding through the skin as well as visceral metastases following two previous resections for cutaneous neoplasms. Histopathology showed spindle morphology and positive staining for keratins, desmin, MYOD1, and myogenin. Genetic sequencing showed a non-canonical TFCP2::FUS fusion that, in combination with the immunohistochemistry, was diagnostic of RMS. He was treated with vincristine, dactinomycin, and cyclophosphamide, followed by cabozantinib and pembrolizumab, and finally pembrolizumab and concurrent radiation therapy to the targetable lesions. He had a continual, rapid progression of disease and expired two months following radiation.

Conclusion: This case is notable because it presents a rare example of an aggressive, TFCP2::FUS gene fusion-positive RMS presenting with multiple cutaneous metastases, and highlights that this entity is highly resistant to multiple chemotherapies, immunotherapy, and radiation therapy.
DOI: 10.3535/lkd-gjq-yfj
title: Parastichtis suspecta Hübner, 1809

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/9p6-mgq-yws
title: Aporia crataegi (Linnaeus, 1758)

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/gtm-r9f-ksb
title: Pyrausta purpuralis Linnaeus, 1758

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.6084/m9.figshare.30797795
title: Supplementary Material for: Case report: BONE MARROW INFILTRATION WITH ANEMIA AND THROMBOCYTOPENIA, RARE INITIAL SYMPTOMS OF BREAST CANCER

description: Introduction: Bone metastasis is common in breast cancer, causing pain, myelosuppression, and hypercalcemia. However, bone marrow invasion leading to pancytopenia is exceedingly rare, and its optimal treatment remains a subject of debate. This report presents the first such case from Vietnam, where chemotherapy proved effective.
Case presentation: A 47-year-old female patient presented to the emergency department with cough, dyspnea, and back pain. Initial laboratory tests revealed WBC 21.83 G/L, Neutrophil 10.97 G/L, Hct 27.3%, Hgb 87 g/L, and PLT 22 G/L. Further examination identified a left breast tumor with skin invasion, as well as metastases to the bone, liver, lungs, pleura, cervical lymph nodes, and mediastinal lymph nodes. Bone marrow aspiration confirmed the presence of malignant cell invasion. The patient responded well to chemotherapy with doxorubicin and cyclophosphamide, with platelet counts recovering immediately after the first cycle.
Conclusion: Bone marrow infiltration causing pancytopenia is a rare but serious manifestation of metastatic breast cancer. Management should follow general principles for metastatic breast cancer. Chemotherapy can be considered when rapid disease control is needed or in patients with marrow failure, provided that doses are individualized and treatment is closely monitored. Further data are required to better define optimal therapy in this setting.
DOI: 10.6084/m9.figshare.30797795.v1
title: Supplementary Material for: Case report: BONE MARROW INFILTRATION WITH ANEMIA AND THROMBOCYTOPENIA, RARE INITIAL SYMPTOMS OF BREAST CANCER

description: Introduction: Bone metastasis is common in breast cancer, causing pain, myelosuppression, and hypercalcemia. However, bone marrow invasion leading to pancytopenia is exceedingly rare, and its optimal treatment remains a subject of debate. This report presents the first such case from Vietnam, where chemotherapy proved effective.
Case presentation: A 47-year-old female patient presented to the emergency department with cough, dyspnea, and back pain. Initial laboratory tests revealed WBC 21.83 G/L, Neutrophil 10.97 G/L, Hct 27.3%, Hgb 87 g/L, and PLT 22 G/L. Further examination identified a left breast tumor with skin invasion, as well as metastases to the bone, liver, lungs, pleura, cervical lymph nodes, and mediastinal lymph nodes. Bone marrow aspiration confirmed the presence of malignant cell invasion. The patient responded well to chemotherapy with doxorubicin and cyclophosphamide, with platelet counts recovering immediately after the first cycle.
Conclusion: Bone marrow infiltration causing pancytopenia is a rare but serious manifestation of metastatic breast cancer. Management should follow general principles for metastatic breast cancer. Chemotherapy can be considered when rapid disease control is needed or in patients with marrow failure, provided that doses are individualized and treatment is closely monitored. Further data are required to better define optimal therapy in this setting.
DOI: 10.3535/21c-ddk-vt0
title: Aporia crataegi (Linnaeus, 1758)

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/n5c-h3d-x7k
title: Speyeria aglaja (Linnaeus, 1758)

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/cvt-hlv-1k3
title: Charanyca (Charanyca) trigrammica (Hufnagel, 1766)

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/g0p-em6-rl8
title: Aporia crataegi (Linnaeus, 1758)

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/dtf-zbc-40p
title: Aricia artaxerxes (Fabricius, 1793)

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/v4z-rct-v5y
title: Nycteola degenerana (Hübner, 1799)

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/vgk-bcn-84f
title: Udea olivalis [Denis & Schiffermüller]

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.6084/m9.figshare.30797798
title: Supplementary Material for: Human Metapneumovirus Infection Manifesting as Skin Eruption and Hand Swelling: A Case Report

description: Human metapneumovirus (HMPV) is a respiratory pathogen that affects both children and adults and can be severe in the elderly and immunocompromised hosts. The virus usually results in a spectrum of respiratory illnesses. There is growing evidence that HMPV is also responsible for a variety of skin eruptions. An immunocompromised 7-year old patient with HMPV infection is presented with a severe skin eruption and painful swelling of the hand requiring hospital admission.
DOI: 10.6084/m9.figshare.30797798.v1
title: Supplementary Material for: Human Metapneumovirus Infection Manifesting as Skin Eruption and Hand Swelling: A Case Report

description: Human metapneumovirus (HMPV) is a respiratory pathogen that affects both children and adults and can be severe in the elderly and immunocompromised hosts. The virus usually results in a spectrum of respiratory illnesses. There is growing evidence that HMPV is also responsible for a variety of skin eruptions. An immunocompromised 7-year old patient with HMPV infection is presented with a severe skin eruption and painful swelling of the hand requiring hospital admission.
DOI: 10.3535/dy9-pez-ycb
title: Boloria Moore, 1900

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/mj9-w7f-2ng
title: Diacrisia sannio (Linnaeus, 1758)

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/5yp-hsf-95r
title: Diacrisia sannio (Linnaeus, 1758)

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/gv3-jtd-l38
title: Boloria Moore, 1900

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.6084/m9.figshare.30797801
title: Supplementary Material for: UCP2-driven fatty acid oxidation promotes macrophage M2 polarization and renal fibrosis

description: During renal fibrosis, macrophages play a crucial role in multiple processes, such as initiating inflammation, mediating tissue repair, and promoting interstitial fibrosis. Macrophage polarization is a key determinant of their functional properties. To investigate the roles and mechanism of macrophages with distinct phenotype in renal fibrosis, we established unilateral ureteral obstruction (UUO) and ischemia-reperfusion injury (I/R) models. Our results indicate that the energy metabolism pattern is a key factor during macrophage phenotypic switching. Specifically, Uncoupling protein 2 (UCP2), a mitochondrial inner membrane protein, was found to regulate the metabolic profile of macrophages. Knockout of Ucp2 in macrophages led to reduced fatty acid oxidation, downregulation of M2 phenotype markers, and alleviation of renal fibrosis. We further employed a chimeric model via adoptive transfer of macrophages. Attenuation of renal interstitial fibrosis was observed in wild-type mice receiving Ucp2-deficient (Ucp2- KO) macrophages. In contrast, adoptive transfer of wild-type macrophages into Ucp2- KO mice resulted in a marked aggravation of renal fibrosis. In summary, we identify UCP2 as a key regulator of macrophage metabolic reprogramming and a critical promoter of renal fibrosis, suggesting that targeting UCP2 represents a promising therapeutic strategy.
DOI: 10.6084/m9.figshare.30797801.v1
title: Supplementary Material for: UCP2-driven fatty acid oxidation promotes macrophage M2 polarization and renal fibrosis

description: During renal fibrosis, macrophages play a crucial role in multiple processes, such as initiating inflammation, mediating tissue repair, and promoting interstitial fibrosis. Macrophage polarization is a key determinant of their functional properties. To investigate the roles and mechanism of macrophages with distinct phenotype in renal fibrosis, we established unilateral ureteral obstruction (UUO) and ischemia-reperfusion injury (I/R) models. Our results indicate that the energy metabolism pattern is a key factor during macrophage phenotypic switching. Specifically, Uncoupling protein 2 (UCP2), a mitochondrial inner membrane protein, was found to regulate the metabolic profile of macrophages. Knockout of Ucp2 in macrophages led to reduced fatty acid oxidation, downregulation of M2 phenotype markers, and alleviation of renal fibrosis. We further employed a chimeric model via adoptive transfer of macrophages. Attenuation of renal interstitial fibrosis was observed in wild-type mice receiving Ucp2-deficient (Ucp2- KO) macrophages. In contrast, adoptive transfer of wild-type macrophages into Ucp2- KO mice resulted in a marked aggravation of renal fibrosis. In summary, we identify UCP2 as a key regulator of macrophage metabolic reprogramming and a critical promoter of renal fibrosis, suggesting that targeting UCP2 represents a promising therapeutic strategy.
DOI: 10.3535/va8-tp3-kgf
title: Polychrysia moneta (Fabricius, 1787)

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/y9m-ywc-1yv
title: Diacrisia sannio (Linnaeus, 1758)

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/86e-w82-s9p
title: Euclidia (Euclidia) glyphica Linnaeus, 1758

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/zlt-n3y-v0n
title: Autographa macrogamma (Eversmann, 1842)

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/0ha-mqz-cpf
title: Pyrausta purpuralis Linnaeus, 1758

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/ssj-pvq-m7y
title: Hypena proboscidalis (Linnaeus, 1758)

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.6084/m9.figshare.30797804
title: Supplementary Material for: Impact of Airborne Pollen on Allergic Rhinitis and Asthma in an Arid Chinese City: A Time-Series Study from Lanzhou

description: Airborne pollen has emerged as a critical environmental driver of allergic respiratory diseases, particularly under the accelerating influence of global climate change. This study investigates the short-term effects of daily airborne pollen concentrations on the incidence of allergic rhinitis (AR) and bronchial asthma (BA) in Lanzhou, a representative arid city in northwestern China. Utilizing outpatient visit data from a Class A tertiary hospital between April and October 2024, along with daily records of pollen concentrations, meteorological indicators, and air pollutant levels, we employed a Distributed Lag Non-linear Model (DLNM) to examine the non-linear and lagged relationships between pollen exposure and disease risk. Our findings reveal a significant association between elevated pollen levels and increased risks of both AR and BA, with the strongest effects observed within 1–3 days after exposure. Stratified analyses show that females and individuals aged 0–19 years are particularly susceptible. Moreover, health impacts were more pronounced during the late summer to autumn pollen season, likely due to the presence of highly allergenic species such as Artemisia and Chenopodiaceae. Thunderstorm events were also found to coincide with spikes in pollen concentrations and disease incidence, suggesting a potential link to thunderstorm-related allergic exacerbations. These results underscore the urgent need for region-specific pollen monitoring systems, early warning mechanisms, and targeted public health interventions to mitigate the burden of allergic respiratory diseases in vulnerable populations, particularly under increasingly volatile climatic conditions.
DOI: 10.6084/m9.figshare.30797804.v1
title: Supplementary Material for: Impact of Airborne Pollen on Allergic Rhinitis and Asthma in an Arid Chinese City: A Time-Series Study from Lanzhou

description: Airborne pollen has emerged as a critical environmental driver of allergic respiratory diseases, particularly under the accelerating influence of global climate change. This study investigates the short-term effects of daily airborne pollen concentrations on the incidence of allergic rhinitis (AR) and bronchial asthma (BA) in Lanzhou, a representative arid city in northwestern China. Utilizing outpatient visit data from a Class A tertiary hospital between April and October 2024, along with daily records of pollen concentrations, meteorological indicators, and air pollutant levels, we employed a Distributed Lag Non-linear Model (DLNM) to examine the non-linear and lagged relationships between pollen exposure and disease risk. Our findings reveal a significant association between elevated pollen levels and increased risks of both AR and BA, with the strongest effects observed within 1–3 days after exposure. Stratified analyses show that females and individuals aged 0–19 years are particularly susceptible. Moreover, health impacts were more pronounced during the late summer to autumn pollen season, likely due to the presence of highly allergenic species such as Artemisia and Chenopodiaceae. Thunderstorm events were also found to coincide with spikes in pollen concentrations and disease incidence, suggesting a potential link to thunderstorm-related allergic exacerbations. These results underscore the urgent need for region-specific pollen monitoring systems, early warning mechanisms, and targeted public health interventions to mitigate the burden of allergic respiratory diseases in vulnerable populations, particularly under increasingly volatile climatic conditions.
DOI: 10.3535/f16-4g8-xwc
title: Chersotis cuprea [Denis & Schiffermüller], 1775

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/g9q-4qw-zwg
title: Aporia crataegi (Linnaeus, 1758)

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/gnk-0dg-c4j
title: Speyeria aglaja (Linnaeus, 1758)

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/p37-2xd-4mj
title: Amphipoea fucosa Freyer, 1830

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/aj0-azm-n5e
title: Vanessa cardui (Linnaeus, 1758)

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/tn5-ct4-d73
title: Boloria aquilonaris (Stichel, 1908)

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.6084/m9.figshare.30797807
title: Supplementary Material for: When STI Treatment Fails: A Rare Dermatological Presentation of Lung Cancer –A Case Report

description: Introduction:
Cutaneous metastases are uncommon but may represent the first clinical manifestation of internal malignancies. In men, lung cancer is the most frequent source of such lesions. Due to their variable presentation, these metastases can mimic sexually transmitted infections (STIs) and delay the correct diagnosis.

Case Presentation:
A 46-year-old male presented with a painless ulcerative lesion in the right inguinal region that had persisted for one month. Despite broad-spectrum antibiotic therapy, there was no clinical improvement. Histopathological and immunohistochemical evaluation of a skin biopsy revealed positivity for CK7 and TTF-1, consistent with metastatic lung adenocarcinoma. Subsequent imaging and bronchoscopic biopsy confirmed non-mucinous adenocarcinoma of the lung.

Conclusion:
This case highlights the importance of considering internal malignancies in the differential diagnosis of genital and inguinal ulcerative lesions, particularly when conventional treatments fail. Early biopsy and immunohistochemical analysis are essential for accurate diagnosis and timely management.