cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.14288/1.0397768
title: Data from: Extra-pair paternity and the variance in male fitness in song sparrows (Melospiza melodia)

description: &lt;b&gt;Abstract&lt;/b&gt;&lt;br/&gt;The variance in fitness across population members can influence major evolutionary processes. In socially monogamous but genetically polygynandrous species, extra-pair paternity (EPP) is widely hypothesized to increase the variance in male fitness compared to that arising given the socially monogamous mating system. This hypothesis has not been definitively tested because comprehensive data describing males’ apparent (social) and realized (genetic) fitness have been lacking. We used 16 years of comprehensive social and genetic paternity data for an entire free-living song sparrow (Melospiza melodia) population to quantify and compare variances in male apparent and realized fitness, and to quantify the contribution of the variances in within-pair and extra-pair reproductive success and their covariance to the variance in realized fitness. Overall, EPP increased the variance in male fitness by only 0-27% across different fitness and variance measures. This relatively small effect reflected the presence of socially unpaired males with zero apparent and low realized fitness, small covariance between within- and extra-pair reproductive success and large variance in within-pair reproductive success that was relatively unaffected by EPP. Therefore, although EPP altered individual males’ contributions to future generations, its impact on population-level parameters such as the opportunity for selection and effective population size was limited.
DOI: 10.14288/1.0397769
title: Data from: Population genetic structure of the western cherry fruit fly Rhagoletis indifferens (Diptera: Tephritidae) in British Columbia, Canada

description: &lt;b&gt;Abstract&lt;/b&gt;&lt;br/&gt;1. Population connectivity and movement are key ecological parameters influencing the impact of pests, and are important considerations in control strategies. For many insects, these parameters are difficult to assess directly, although they may be assessed indirectly using population genetic data. 2. We used microsatellite markers to examine population genetic structure of the western cherry fruit fly, the main pest of cherry crops in western North America, in British Columbia, Canada, and make inferences about connectivity and potential for movement among populations. 3. Comparing populations from four geographical regions (separated by up to approximately 400 km), we found significant genetic differentiation both among and within regions. Using populations as the units of analysis, we observed significant isolation by distance (IBD) at larger spatial scales but not below approximately 20 km. By contrast, using individual flies as the units of analysis, we found significant IBD at scales as small as &lt; 100 m. We saw no evidence of genetic differentiation among populations sampled from different species/varieties of plants. 4. Our results suggest that the movement of individual flies is limited, although high levels of gene flow are maintained at scales of up to 20 km, possibly through combined effects of stepping-stone gene flow and large population sizes.
DOI: 10.14288/1.0397772
title: Data from: Genetic approaches refine ex situ lowland tapir (Tapirus terrestris) conservation

description: &lt;b&gt;Abstract&lt;/b&gt;&lt;br/&gt;Ex situ conservation management remains an important tool in the face of continued habitat loss and global environmental change. Here, we use microsatellite marker variation to evaluate conventional assumptions of pedigree-based ex situ population management and directly inform a captive lowland tapir breeding program within a range country. We found relatively high levels of genetic variation (Ntotal = 41; mean HE = 0.67 over 10 variable loci) and little evidence for relatedness among founder individuals (Nfounders = 10; mean relatedness = -0.05). Seven of 29 putative parent-offspring relationships were excluded by parentage analysis based on allele-sharing, and we identified two individuals of high genetic value to the population (mk ≤ 0.007) that would otherwise have been excluded from the breeding program. Traditional assumptions of founders being unrelated and individuals of unknown origin being highly related led to overestimates of mean kinship and inbreeding, and underestimates of gene diversity, when compared to values found when genetic markers were used to inform kinship. We discuss our results within the context of recent studies that have assessed the utility of neutral molecular markers for ex situ conservation.
DOI: 10.14288/1.0397774
title: Data from: Accelerometers can measure total and activity-specific energy expenditure in free-ranging marine mammals only if linked to time-activity budgets

description: &lt;b&gt;Abstract&lt;/b&gt;&lt;br/&gt;Energy expenditure is an important component of foraging ecology, but is extremely difficult to estimate in free-ranging animals and depends on how animals partition their time between different activities during foraging. Acceleration data have emerged as a new way to determine energy expenditure at a fine scale but this needs to be tested and validated in wild animals. This study investigated whether vectorial dynamic body acceleration (VeDBA) could accurately predict the energy expended by marine predators during a full foraging trip. We also aimed to determine whether the accuracy of predictions of energy expenditure derived from acceleration increased when partitioned by different types of at-sea activities (i.e. diving, transiting, resting and surface activities). To do so, we equipped 20 lactating northern (Callorhinus ursinus) and 20 lactating Antarctic fur seals (Arctocephalus gazella) with GPS, time-depth recorders and tri-axial accelerometers and obtained estimates of field metabolic rates using the doubly labelled water (DLW) method. VeDBA was derived from tri-axial acceleration, and at-sea activities (diving, transiting, resting and surface activities) were determined using dive depth, tri-axial acceleration and travelling speed. We found that VeDBA did not accurately predict the total energy expended by fur seals during their full foraging trips (R2 = 0·36). However, the accuracy of VeDBA as a predictor of total energy expenditure increased significantly when foraging trips were partitioned by activity and when activity-specific VeDBA was paired with time-activity budgets (R2 = 0·70). Activity-specific VeDBA also accurately predicted the energy expenditures of each activity independent of each other (R2 &gt; 0·85). Our study confirms that acceleration is a promising way to estimate energy expenditures of free-ranging marine mammals at a fine scale never attained before. However, it shows that it needs to be based on the time-activity budgets that make up foraging trips rather than being derived as a single measure of VeDBA applied to entire foraging trips. Our activity-based method provides a cost-effective means to accurately calculate energy expenditures of fur seals using acceleration and time-activity budgets, that can be transfered to studies on other species.
DOI: 10.14288/1.0397777
title: Data from: The red queen coupled with directional selection favors the evolution of sex

description: &lt;b&gt;Abstract&lt;/b&gt;&lt;br/&gt;Why sexual reproduction has evolved to be such a widespread mode of reproduction remains a major question in evolutionary biology. While previous studies have shown that increased sex and recombination can evolve in the presence of host-parasite interactions (the “Red Queen hypothesis” for sex), many of these studies have assumed that multiple loci mediate infection versus resistance. Data suggest, however, that a major locus is typically involved in antigen presentation and recognition. Here, we explore a model where only one locus mediates host-parasite interactions, but a second locus is subject to directional selection. Even though the effects of these genes on fitness are independent, we show that increased rates of sex and recombination are favored at a modifier gene that alters the rate of genetic mixing. This result occurs because of selective interference that occurs in finite populations (the “Hill-Robertson effect”), which also favors sex. These results suggest that the Red Queen hypothesis may help to explain the evolution of sex by contributing a form of persistent selection, which interferes with directional selection at other loci and thereby favors sex and recombination.
DOI: 10.14288/1.0397778
title: Data from: Insights into the roles of CMK-1 and OGT-1 in interstimulus interval-dependent habituation in Caenorhabditis elegans

description: &lt;b&gt;Abstract&lt;/b&gt;&lt;br/&gt;Habituation is a ubiquitous form of non-associative learning observed as a decrement in responding to repeated stimulation that cannot be explained by sensory adaptation or motor fatigue. One of the defining characteristics of habituation is its sensitivity to the rate at which training stimuli are presented – animals habituate faster in response to more rapid stimulation. The molecular mechanisms underlying this interstimulus interval (ISI)-dependent characteristic of habituation remain unknown. In this article we use behavioral neurogenetic and bioinformatic analyses in the nematode Caenorhabiditis elegans to identify the first molecules that modulate habituation in an ISI-dependent manner. We show that the Caenorhabditis elegans orthologs of Ca2+/calmodulin-dependent kinases CaMK1/4, CMK-1, and O-linked N-acetylglucosamine (O-GlcNAc) transferase, OGT-1, both function in primary sensory neurons to inhibit habituation at short ISIs and promote it at long ISIs. In addition, both cmk-1 and ogt-1 mutants display a rare mechanosensory hyper-responsive phenotype, i.e. larger mechanosensory responses than wild-type. Overall, our work identifies two conserved genes that function in sensory neurons to modulate habituation in an ISI-dependent manner, providing the first insights into the molecular mechanisms underlying the universally observed phenomenon that habituation has different properties when stimuli are delivered at different rates.
DOI: 10.14288/1.0397781
title: Data from: EFHC1, implicated in juvenile myoclonic epilepsy, functions at the cilium and synapse to modulate dopamine signaling

description: &lt;b&gt;Abstract&lt;/b&gt;&lt;br/&gt;Neurons throughout the mammalian brain possess non-motile cilia, organelles with varied functions in sensory physiology and cellular signaling, yet their roles in these neurons are poorly understood. To shed light into their functions, we studied EFHC1, an evolutionarily conserved protein required for motile cilia function and linked to a common form of inherited epilepsy in humans, juvenile myoclonic epilepsy (JME). We demonstrate that C. elegans EFHC1 functions within specialized non-motile mechanosensory cilia, where it regulates neuronal activation and dopamine signaling. EFHC1 also localizes at the synapse, where it further modulates dopamine signaling in cooperation with the orthologue of an R-type voltage-gated calcium channel. Our findings unveil a previously undescribed dual-regulation of neuronal excitability at sites of neuronal sensory input (cilium) and neuronal output (synapse). Such a distributed regulatory mechanism may be essential for establishing neuronal activation thresholds under physiological conditions, and when impaired, may represent a novel pathomechanism for epilepsy.
DOI: 10.14288/1.0397782
title: Data from: Survival is negatively related to basal metabolic rate in tropical Andean birds

description: &lt;b&gt;Abstract&lt;/b&gt;&lt;br/&gt;1. Life history theory postulates that physiological traits, such as energy metabolism, can be understood in terms of allocation trade-offs between self-maintenance and reproduction over an organism’s lifespan, and data show that metabolic intensity and survival vary inversely with latitude, with tropical birds exhibiting a ‘slow’ pace of life relative to temperature species. However, tropical regions harbor strong environmental gradients of their own, and it remains to be shown whether similar life history trade-offs between metabolism and longevity are reflected among tropical birds of the same latitude. 2. We estimated apparent annual survival in 37 species of tropical passerine birds along an elevational gradient (400–3000 m) in Peru to test whether variation in survival was influenced by basal metabolic rate (BMR; estimated at the same sites), elevation or both factors. We used path analysis to test our prediction that survival would decline as BMR increased, while accounting for the potential direct effects of elevation on survival due to differences in predation pressure or environmental conditions as well as potential indirect effects of elevation on BMR via temperature and the costs of thermoregulation. 3. Higher BMR in tropical passerine birds predicted lower apparent survival, regardless of the elevation at which species occurred. In addition, elevation had a direct negative effect on apparent survival, perhaps due to harsher abiotic conditions, low site fidelity, or both at high elevations. 4. We provide evidence of a link between metabolic rate and longevity previously undescribed in populations of free-living birds. Our results illustrate that tropical montane species may be characterized by a unique suite of traits in their pace of life, in which BMR does not differ from lowland birds, but survival does.
DOI: 10.14288/1.0397784
title: Data from: Predators, energetics and fitness drive neonatal reproductive failure in red squirrels

description: &lt;b&gt;Abstract&lt;/b&gt;&lt;br/&gt;Neonatal reproductive failure should occur when energetic costs of parental investment outweigh fitness benefits. However, little is known about the drivers of neonatal reproductive failure in free ranging species experiencing continuous natural variation in predator abundance and in the energetic and fitness costs and benefits associated with parental investment. Long-term comprehensive studies are required to better understand how biotic, abiotic, and life history conditions interact to drive occurrences of reproductive failure in the wild. Using 24 years (1987-2011) of reproductive data from a northern boreal population of North American red squirrels in southwestern Yukon, we examined the effects of predator abundance, energetics (resource availability, ambient temperature and litter size), and fitness benefits (probability of overwinter juvenile survival and maternal age) on occurrences of neonatal reproductive failure (494/2670 reproductive attempts; 18.5%). Neonatal reproductive failure was driven by a combination of predator abundance, and the energetic and fitness costs and benefits of parental investment. The abundance of mustelids and maternal age were positively related to the occurrence of neonatal reproductive failure. High energy costs associated with a combination of low resource availability and cold ambient temperatures or large litters, corresponded to increased occurrences of neonatal reproductive failure. However, the strength of these relationships was influenced by variation in juvenile overwinter survival (i.e. fitness benefits). We provide evidence that predation pressure is an important driver of neonatal reproductive failure. In addition, we found a trade-off occurs between resource-dependent energetic and fitness costs and benefits of raising the current litter to independence
DOI: 10.14288/1.0397785
title: Data from: Genetic relationships between Atlantic and Pacific populations of the notothenioid fish Eleginops maclovinus: the footprints of Quaternary glaciations in Patagonia

description: &lt;b&gt;Abstract&lt;/b&gt;&lt;br/&gt;The genetic relationships between the Pacific and the Atlantic populations of marine costal biota in Southern South America have been analyzed in few studies, most of them relying on a single mitochondrial locus. We analyzed ten polymorphic microsatellite loci, isolated from a dinucleotide-enriched E. maclovinus genomic library, in a total of 240 individuals (48 from each of five sampled sites: two Atlantic, two Pacific and one in Beagle Channel). The results were contrasted against a previous work on the same species with mtDNA. Observed heterozygosity within localities ranged from 0.85 to 0.88 and the highest overall number of alleles was observed at the northernmost locality on the Pacific side (Concepción) but no clear geographic pattern arose from the data. On the other hand, the number of private alleles was negatively correlated with latitude (Spearman's rs test, p = 0.017). Among-population variance was low but significant (1.35 %; p &lt; 0.0001, AMOVA) and low genetic differentiation between populations was observed (pairwise FST values ranged from 0 to 0.021). A Mantel test reveled a significant correlation between geographic distances and FST (r = 0.56, p = 0.047). This could be partially accounted for the Atlantic vs Pacific population differentiation detected in three different analyses (Structure, SAMOVA and a population phylogeny). The observed pattern is compatible with a history of separation into two glacial refugia, which was better captured by the multilocus microsatellite data than by the mtDNA analysis.
DOI: 10.14288/1.0397788
title: Data from: Validation of an algorithm for identifying MS cases in administrative health claims datasets

description: &lt;b&gt;Abstract&lt;/b&gt;&lt;br/&gt;Objective: To develop a valid algorithm for identifying multiple sclerosis (MS) cases in administrative health claims (AHC) datasets. Methods: We used 4 AHC datasets from the Veterans Administration (VA), Kaiser Permanente Southern California (KPSC), Manitoba (Canada), and Saskatchewan (Canada). In the VA, KPSC, and Manitoba, we tested the performance of candidate algorithms based on inpatient, outpatient, and disease-modifying therapy (DMT) claims compared to medical records review using sensitivity, specificity, positive and negative predictive values, and interrater reliability (Youden J statistic) both overall and stratified by sex and age. In Saskatchewan, we tested the algorithms in a cohort randomly selected from the general population. Results: The preferred algorithm required ≥3 MS-related claims from any combination of inpatient, outpatient, or DMT claims within a 1-year time period; a 2-year time period provided little gain in performance. Algorithms including DMT claims performed better than those that did not. Sensitivity (86.6%–96.0%), specificity (66.7%–99.0%), positive predictive value (95.4%–99.0%), and interrater reliability (Youden J = 0.60–0.92) were generally stable across datasets and across strata. Some variation in performance in the stratified analyses was observed but largely reflected changes in the composition of the strata. In Saskatchewan, the preferred algorithm had a sensitivity of 96%, specificity of 99%, positive predictive value of 99%, and negative predictive value of 96%. Conclusions: The performance of each algorithm was remarkably consistent across datasets. The preferred algorithm required ≥3 MS-related claims from any combination of inpatient, outpatient, or DMT use within 1 year. We recommend this algorithm as the standard AHC case definition for MS.
DOI: 10.14288/1.0397789
title: Data from: Estimating density for species conservation: comparing camera trap spatial count models to genetic spatial capture-recapture models

description: &lt;b&gt;Abstract&lt;/b&gt;&lt;br/&gt;Density estimation is integral to the effective conservation and management of wildlife. Camera traps in conjunction with spatial capture-recapture (SCR) models have been used to accurately and precisely estimate densities of “marked” wildlife populations comprising identifiable individuals. The emergence of spatial count (SC) models holds promise for cost-effective density estimation of “unmarked” wildlife populations when individuals are not identifiable. We evaluated model agreement, precision, and survey costs, between i) a fully marked approach using SCR models fit using non-invasive genetic data, and ii) an unmarked approach using SC models fit using camera trap data, for a recovering population of the mesocarnivore fisher (Pekania pennanti). The SCR density estimates ranged from 2.95 to 3.42 (2.18–5.19 95% BCI) fishers 100 km−2. The SC density estimates were influenced by their priors, ranging from 0.95 (0.65–2.95 95% BCI) fishers 100 km−2 for the uninformative model to 3.60 (2.01–7.55 95% BCI) fishers 100 km−2 for the model informed by prior knowledge of a 16 km2 fisher home range. We caution against using strongly informative priors but instead recommend using a range of unweighted prior knowledge. Thin detection data was problematic for both SCR and SC models, potentially producing biased low estimates. The total cost of the genetic survey ($47 610) was two-thirds of the camera trap survey ($77 080), or comparable ($75 746) if genetic sampling effort was increased to include sex and trap-behaviour covariates in SCR models. Density estimation of unmarked populations continues to be a series of trade-offs but as methods improve and integrate, so will our estimates.
DOI: 10.14288/1.0397790
title: Data from: Aggressive behaviours, food deprivation and the foraging gene

description: &lt;b&gt;Abstract&lt;/b&gt;&lt;br/&gt;A pleiotropic gene governs multiple traits, which might constrain the evolution of complexity due to conflicting selection on these traits. However, if the pleiotropic effect is modular, then this can facilitate synergistic responses to selection on functionally related traits, thereby leveraging the evolution of complexity. To understand the evolutionary consequence of pleiotropy, the relation among functionally different traits governed by the same gene is key. We examined a pleiotropic function of the foraging (for) gene with its rover and sitter allelic variants in fruit fly, Drosophila melanogaster. We measured for's effect on adult male aggressive behaviours and whether this effect was shaped by for's known role in food-related traits. Rover exhibited higher levels of offensive behaviour than sitters and s2, a sitter-like mutant on rover genetic background. With a Markov chain model, we estimated the rate of aggression escalation, and found that the rover pattern of aggressive escalation more rapidly intensified fights. Subsequent analysis revealed that this was not caused by for's effect on food-related traits, suggesting that for might directly regulate aggressive behaviours. Food deprivation did not elevate aggression, but reduced intermediate-level aggressive behaviours. Aggression and other foraging-related behaviour might comprise a synergistic trait module underlaid by this pleiotropic gene.
DOI: 10.5517/ccdc.csd.cc2p1qxd
title: CCDC 2474324: Experimental Crystal Structure Determination

description: Related Article: Ranjusree Cherukunnath and Srinivasan Karuppannan|2025|CSD Communication|||
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.