DOI: 10.5061/dryad.464vm
title: Data from: Diagnostic and prognostic value of the cerebrospinal fluid concentration of immunoglobulin free light chains in clinically isolated syndrome with conversion to multiple sclerosis

description: Background and objective: In this study, we evaluated the diagnostic and
 prognostic significance of cerebrospinal fluid free light chains (CSF FLC)
 at the time of clinically isolated syndrome (CIS). Methods: We compared
 FLC-parameters at the moment of CIS in patients with conversion to
 multiple sclerosis (MS) after 2 years (CIS-MS), patients who remained
 stable both clinically and radiologically after 2 years (CIS-nonMS),
 patients with non-inflammatory neurologic diseases (NIND) as a comparison
 group and patients with other inflammatory neurologic diseases (IND) with
 intrathecal oligoclonal bands (OCB) synthesis. ROC-analysis was conducted
 to define FLC-assay characteristics and cut-off values. We also compared
 FLC-concentrations in CIS patients to determine their OCB-status. A
 correlation analysis was performed between FLC-concentrations and the
 expanded disability scale score (EDSS), annualized relapse rate (ARR) and
 MRI-activity (i.e., number of new and gadolinium-enhancing (Gd+) lesions)
 in patients. Results: The levels of kappa-FLC (k-FLCCSF) and lambda-FLC
 (λ-FLCCSF) as well as kappa- and lambda-quotients (Q-k and Q-λ) were
 elevated in CIS-MS compared to the CIS-nonMS and NIND groups. These levels
 did not differ significantly when compared with the IND group. We
 identified several patients with high k-FLCCSF and λ-FLCCSF in
 OCB-negative CIS and IND groups. The level of k-FLCCSF production was
 significantly higher in OCB-positive patients in the CIS-MS group compared
 to the CIS-nonMS group. The concentrations of k-FLCCSF and Q-k in the
 CIS-MS group showed significant correlation with the level of EDSS after 2
 years (k-FLC: r = 0.4477,p = 0.0016; Q-k: r = 0.4621, p = 0.0016).
 λ-FLCCSF and Q-λ inversely correlated with the number of Gd+ lesions (CSF
 λ-FLC: r = -0.3698, p = 0.0223; Q-λ: r = -0.4527, p = 0.0056). Conclusion:
 The concentration of CSF FLC predicts conversion to MS within 2 years
 following CIS. OCB-positive patients with an early conversion have a
 higher concentration of CSF-FLC. We have also shown a prognostic
 significance of k-FLCCSF for future EDSS-progression.
description: Immunoglobulin free
 light chains in clinically isolated syndrome with conversion to multuiple
 sclerosisThis data file
 represents the concentrations of immunoglobulin free light chains in 4
 groups of patients: 1) CIS-MS (clinically isolated syndrome with
 conversion to multiple sclerosis during 2 years) 2) CIS-nonMS (clinically
 isolated syndrome without conversion to multiple sclerosis during 2 years)
 3) NIND - non-inflammatory neurologic disorders 4) IND - inflammatory
 neurologic disorders. This data was collected from clinical database and
 laboratory tests database for every patient. The data file was created
 with Microsoft Excel. Abbreviations: FLC - free light chains, CSF -
 cerebrospinal fluid, Q - quotient of concentration (th ratio of
 concentrations in CSF/serum), OCB - oligoclonal bands, abs -
 absent.Data
 file.xlsx