cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.6991922
title: Persistence and efficacy of a new formulation based on dog allomonal repellents against Rhipicephalus sanguineus sensu lato tick

description: Abstract Beagles are less susceptible to Rhipicephalus sanguineus sensu lato tick due to the production of the allomones benzaldehyde and 2-hexanone. Our previous published work showed that these compounds can reduce tick burden on susceptible dogs. Here we tested the hypothesis that an increase in repellent dose and release rate could increase repellent efficacy and persistence. Slow-release formulations of these compounds, with higher doses and release rates, were tested on artificially-infested dogs. Ten dogs were randomly assigned to two groups with five dogs each. The treated group received collars with slow-release formulations of the compounds attached, while the control group received collars with clean formulations attached. Five environmental infestations were performed, with the number of ticks (at all stages) on the dogs being counted once a day for 40 days. No significant increase in repellent efficacy was observed with the higher doses and release rates, whereas a greater persistence in repellent activity was observed. Treatment with the formulations resulted in a two-to-three-fold reduction in the number of immature stage ticks for up to three weeks. However, the number of adults was similar in both groups. Loss of repellent activity after the third week of testing coincided with a marked change in the relative release rates for the two compounds. It is hypothesized that relative amounts, rather than absolute amounts, of repellent release from slow-release formulations are important for repellent activity. We also hypothesize that the avoidance of less-preferred hosts by ticks relies on olfactory-mediated perception of specific blends of volatile cues from less preferred hosts.
DOI: 10.6084/m9.figshare.6991922.v1
title: Persistence and efficacy of a new formulation based on dog allomonal repellents against Rhipicephalus sanguineus sensu lato tick

description: Abstract Beagles are less susceptible to Rhipicephalus sanguineus sensu lato tick due to the production of the allomones benzaldehyde and 2-hexanone. Our previous published work showed that these compounds can reduce tick burden on susceptible dogs. Here we tested the hypothesis that an increase in repellent dose and release rate could increase repellent efficacy and persistence. Slow-release formulations of these compounds, with higher doses and release rates, were tested on artificially-infested dogs. Ten dogs were randomly assigned to two groups with five dogs each. The treated group received collars with slow-release formulations of the compounds attached, while the control group received collars with clean formulations attached. Five environmental infestations were performed, with the number of ticks (at all stages) on the dogs being counted once a day for 40 days. No significant increase in repellent efficacy was observed with the higher doses and release rates, whereas a greater persistence in repellent activity was observed. Treatment with the formulations resulted in a two-to-three-fold reduction in the number of immature stage ticks for up to three weeks. However, the number of adults was similar in both groups. Loss of repellent activity after the third week of testing coincided with a marked change in the relative release rates for the two compounds. It is hypothesized that relative amounts, rather than absolute amounts, of repellent release from slow-release formulations are important for repellent activity. We also hypothesize that the avoidance of less-preferred hosts by ticks relies on olfactory-mediated perception of specific blends of volatile cues from less preferred hosts.
DOI: 10.6084/m9.figshare.6991916
title: Cohort of Patients Referred for Brugada Syndrome Investigation in an Electrophysiology Service - 19-Year Registry

description: Abstract Background: Brugada syndrome (SBr) is an arrhythmic condition characterized by ST-T segment abnormalities in the right precordial leads associated with a high risk of ventricular arrhythmias and sudden death. Local data regarding the clinical characteristics of patients with a typical electrocardiographic (ECG) pattern undergoing electrophysiological study are scarce. Objective: To evaluate patients with an ECG pattern suggestive of SBr referred for electrophysiological evaluation in a specialized center. Methods: Cohort study of patients referred for electrophysiological study because of an ECG pattern compatible with SBr between January 1998 and March 2017. Results: Of the 5506 procedures, 35 (0.64%) were for SBr investigation, 25 of which (71.42%) were performed in men. The mean age was 43.89 ± 13.1 years. The ECG patterns were as follows: type I, 22 (62.85%); type II, 12 (34.30%); and type III, 1 (2.85%). Twenty-three patients (65.7%) were asymptomatic, 6 (17.14%) had palpitations, 5 (14.3%) had syncope, and 3 (8.6%) had a family history of sudden death. Electrophysiological study induced ventricular tachyarrhythmias in 16 cases (45.7%), the mean ventricular refractory period being 228 ± 36 ms. Ajmaline / procainamide was used in 11 cases (31.4%), changing the ECG pattern to type I in 7 (63.6%). Sixteen cases (45.7%) received an implantable cardioverter defibrillator (ICD). In a mean 5-year follow-up, 1 of the 16 patients (6.25%) with ICD had appropriate therapy for ventricular fibrillation. There was no death. Other arrhythmias occurred in 4 (11.4%) cases. Conclusions: Most patients are men, and a type I ECG pattern is the main indication for electrophysiological study. Class IA drugs have a high ECG conversion rate. The ICD event rate was 6%. (Arq Bras Cardiol. 2018; [online].ahead print, PP.0-0)
DOI: 10.6084/m9.figshare.6991910
title: Variability and genetic diversity study in an advanced segregating population of rice with bacterial blight resistance genes introgressed

description: ABSTRACT Bacterial blight disease of rice caused by Xanthomonas oryzae pv. oryzae is one of the most important widespread disease around the globe and can cause severe yield reductions of up to 30% of the total yield. Genetic variability was studied in 54 families of CB 174 R × IRBB 60 rice with bacterial blight resistance genes introgressed at the Department of Rice, Tamil Nadu Agricultural University, Coimbatore, India. Traits such as plant height and the number of productive tillers per plant were found to have negative skewness in this study, indicating the duplication of gene effects. Panicle length and the number of grains per panicle were found to have positive kurtosis, indicating gene interactions. The phenotypic coefficient of variation was slightly higher than the genotypic coefficient of variation for all traits, indicating that the observed variation was not only due to genotypic but also due to the environmental effect on the expression of these traits. High heritability coupled with high genetic advance as a percent of the mean was observed for plant height. Moreover, moderate heritability coupled with high genetic advance as a percent of the mean was observed for the single plant yield of rice. Cluster and principal component analyses revealed that the 54 F2:3 families were grouped into three clusters based on six agro-morphological traits. Clusters III and II had higher mean values for most of the studied traits than cluster I. Intercrossing lines from distinct clusters can be identified and crossed to generate larger variability to produce desirable recombinants for higher yield with a wide genetic base.
DOI: 10.6084/m9.figshare.6991913
title: Comparison surface characteristics and chemical composition of conventional metallic and Nickel-Free brackets

description: This study aims at comparing conventional and nickel-free metal bracket surface characteristics with elemental composition by scanning electron microscopy (SEM), using energy dispersive spectroscopy (EDS). The sample consisted of 40 lower incisor brackets divided into four groups: ABZ = conventional brackets, Kirium Abzil 3M® (n = 10); RL = conventional brackets, Roth Light Morelli® (n = 10); NF = nickel-free brackets, Nickel-Free Morelli® (n = 10); and RM = nickel-free brackets, Roth Max Morelli® (n = 10). Qualitative evaluation of the bracket surface was performed using SEM, whereby surface features were described and compared. The elemental composition was analyzed by EDS. According to surface analysis,groups ABZ and RL showed a homogeneous surface, with better finishing, whereas the surfaces in groups NF and RM were rougher. The chemical components with the highest percentage were Fe, Cr and C. Groups NF and MR showed no nickel in their composition. In conclusion, the bracket surface of the ABZ and RL groups was more homogeneous, with grooves and pores, whereas the surfaces in groups NF and RM showed numerous flaws, cracks, pores and grooves. The chemical composition analysis confirmed that the nickel-free brackets had no Ni in their composition, as confirmed by the manufacturer’s specifications, and were therefore safe to use in patients with a medical history of allergy to this metal.
DOI: 10.6084/m9.figshare.6991916.v1
title: Cohort of Patients Referred for Brugada Syndrome Investigation in an Electrophysiology Service - 19-Year Registry

description: Abstract Background: Brugada syndrome (SBr) is an arrhythmic condition characterized by ST-T segment abnormalities in the right precordial leads associated with a high risk of ventricular arrhythmias and sudden death. Local data regarding the clinical characteristics of patients with a typical electrocardiographic (ECG) pattern undergoing electrophysiological study are scarce. Objective: To evaluate patients with an ECG pattern suggestive of SBr referred for electrophysiological evaluation in a specialized center. Methods: Cohort study of patients referred for electrophysiological study because of an ECG pattern compatible with SBr between January 1998 and March 2017. Results: Of the 5506 procedures, 35 (0.64%) were for SBr investigation, 25 of which (71.42%) were performed in men. The mean age was 43.89 ± 13.1 years. The ECG patterns were as follows: type I, 22 (62.85%); type II, 12 (34.30%); and type III, 1 (2.85%). Twenty-three patients (65.7%) were asymptomatic, 6 (17.14%) had palpitations, 5 (14.3%) had syncope, and 3 (8.6%) had a family history of sudden death. Electrophysiological study induced ventricular tachyarrhythmias in 16 cases (45.7%), the mean ventricular refractory period being 228 ± 36 ms. Ajmaline / procainamide was used in 11 cases (31.4%), changing the ECG pattern to type I in 7 (63.6%). Sixteen cases (45.7%) received an implantable cardioverter defibrillator (ICD). In a mean 5-year follow-up, 1 of the 16 patients (6.25%) with ICD had appropriate therapy for ventricular fibrillation. There was no death. Other arrhythmias occurred in 4 (11.4%) cases. Conclusions: Most patients are men, and a type I ECG pattern is the main indication for electrophysiological study. Class IA drugs have a high ECG conversion rate. The ICD event rate was 6%. (Arq Bras Cardiol. 2018; [online].ahead print, PP.0-0)
DOI: 10.6084/m9.figshare.6991910.v1
title: Variability and genetic diversity study in an advanced segregating population of rice with bacterial blight resistance genes introgressed

description: ABSTRACT Bacterial blight disease of rice caused by Xanthomonas oryzae pv. oryzae is one of the most important widespread disease around the globe and can cause severe yield reductions of up to 30% of the total yield. Genetic variability was studied in 54 families of CB 174 R × IRBB 60 rice with bacterial blight resistance genes introgressed at the Department of Rice, Tamil Nadu Agricultural University, Coimbatore, India. Traits such as plant height and the number of productive tillers per plant were found to have negative skewness in this study, indicating the duplication of gene effects. Panicle length and the number of grains per panicle were found to have positive kurtosis, indicating gene interactions. The phenotypic coefficient of variation was slightly higher than the genotypic coefficient of variation for all traits, indicating that the observed variation was not only due to genotypic but also due to the environmental effect on the expression of these traits. High heritability coupled with high genetic advance as a percent of the mean was observed for plant height. Moreover, moderate heritability coupled with high genetic advance as a percent of the mean was observed for the single plant yield of rice. Cluster and principal component analyses revealed that the 54 F2:3 families were grouped into three clusters based on six agro-morphological traits. Clusters III and II had higher mean values for most of the studied traits than cluster I. Intercrossing lines from distinct clusters can be identified and crossed to generate larger variability to produce desirable recombinants for higher yield with a wide genetic base.
DOI: 10.6084/m9.figshare.6991913.v1
title: Comparison surface characteristics and chemical composition of conventional metallic and Nickel-Free brackets

description: This study aims at comparing conventional and nickel-free metal bracket surface characteristics with elemental composition by scanning electron microscopy (SEM), using energy dispersive spectroscopy (EDS). The sample consisted of 40 lower incisor brackets divided into four groups: ABZ = conventional brackets, Kirium Abzil 3M® (n = 10); RL = conventional brackets, Roth Light Morelli® (n = 10); NF = nickel-free brackets, Nickel-Free Morelli® (n = 10); and RM = nickel-free brackets, Roth Max Morelli® (n = 10). Qualitative evaluation of the bracket surface was performed using SEM, whereby surface features were described and compared. The elemental composition was analyzed by EDS. According to surface analysis,groups ABZ and RL showed a homogeneous surface, with better finishing, whereas the surfaces in groups NF and RM were rougher. The chemical components with the highest percentage were Fe, Cr and C. Groups NF and MR showed no nickel in their composition. In conclusion, the bracket surface of the ABZ and RL groups was more homogeneous, with grooves and pores, whereas the surfaces in groups NF and RM showed numerous flaws, cracks, pores and grooves. The chemical composition analysis confirmed that the nickel-free brackets had no Ni in their composition, as confirmed by the manufacturer’s specifications, and were therefore safe to use in patients with a medical history of allergy to this metal.
DOI: 10.6084/m9.figshare.6991892
title: Evaluation of the quality of life of patients with primary hyperhidrosis submitted to videothoracoscopic sympathectomy

description: ABSTRACT Objective: to evaluate the quality of life of patients undergoing video-assisted thoracoscopy for primary hyperhidrosis. Methods: we evaluated the patients who underwent thoracoscopic sympathectomy to treat primary hyperhidrosis by the team of thoracic surgery at the University Hospital Gaffrée and Guinle - UNIRIO between July 2004 and August 2013. It was applied a questionnaire about quality of life related to hyperhidrosis since preoperative period until one year after the surgery. Results: one hundred twenty two patients answered the questionnaire, with a mean age of 25 years, 57% of whom were women. In relation to severity of primary hyperhidrosis, 83% of the patients reported as tolerable or somewhat tolerable associated with major limitation of quality of life, which it was poor or very poor in 82% of cases. Postoperative compensatory hyperhidrosis occurred in 78% of patients, but it was regarded as invisible or barely noticeable for 85% of these patients, classifying it as acceptable. In 15% of patients, the compensatory sweating was classified as disruptive. Conclusion: thoracoscopic sympathectomy improves the quality of life of patients with primary hyperhidrosis. The transitional compensatory hyperhidrosis occurred in most patients, but did not improve significantly the quality of life.
DOI: 10.6084/m9.figshare.6991892.v1
title: Evaluation of the quality of life of patients with primary hyperhidrosis submitted to videothoracoscopic sympathectomy

description: ABSTRACT Objective: to evaluate the quality of life of patients undergoing video-assisted thoracoscopy for primary hyperhidrosis. Methods: we evaluated the patients who underwent thoracoscopic sympathectomy to treat primary hyperhidrosis by the team of thoracic surgery at the University Hospital Gaffrée and Guinle - UNIRIO between July 2004 and August 2013. It was applied a questionnaire about quality of life related to hyperhidrosis since preoperative period until one year after the surgery. Results: one hundred twenty two patients answered the questionnaire, with a mean age of 25 years, 57% of whom were women. In relation to severity of primary hyperhidrosis, 83% of the patients reported as tolerable or somewhat tolerable associated with major limitation of quality of life, which it was poor or very poor in 82% of cases. Postoperative compensatory hyperhidrosis occurred in 78% of patients, but it was regarded as invisible or barely noticeable for 85% of these patients, classifying it as acceptable. In 15% of patients, the compensatory sweating was classified as disruptive. Conclusion: thoracoscopic sympathectomy improves the quality of life of patients with primary hyperhidrosis. The transitional compensatory hyperhidrosis occurred in most patients, but did not improve significantly the quality of life.
DOI: 10.6084/m9.figshare.6991895
title: Comparison between two methods of scorpion venom milking in Morocco

description: Background The present study compared two methods used successfully in a large-scale program for the collection of scorpion venoms, namely the milking of adult scorpions via manual and electrical stimulation. Results Our immunobiochemical characterizations clearly demonstrate that regularly applied electrical stimulation obtains scorpion venom more easily and, most importantly, in greater quantity. Qualitatively, the electrically collected venom showed lack of hemolymph contaminants such as hemocyanin. In contrast, manual obtainment of venom subjects scorpions to maximal trauma, leading to hemocyanin secretion. Our study highlighted the importance of reducing scorpion trauma during venom milking. Conclusions In conclusion, to produce high quality antivenom with specific antibodies, it is necessary to collect venom by the gentler electrical stimulation method.
DOI: 10.6084/m9.figshare.6991889
title: Correlation between annual activity patterns of venomous snakes and rural people in the Niger Delta, southern Nigeria

description: Background Venomous snakes are among the most serious health hazards for rural people in tropical regions of the world. Herein we compare the monthly activity patterns of eight venomous snake species (Elapidae and Viperidae) with those of rural people in the Niger Delta area of southern Nigeria, in order to identify the periods of highest potential risk for persons, and the human group actually at greater risk of snakebite. Results We documented that above-ground activity of all venomous snakes peaked in the wet season, and that high snake activity and high human activity were most highly correlated between April and August. In addition, we documented that women and teenagers were at relatively higher risk of encountering a venomous snake than adult males, despite they are less often in the field than men. Conclusions Our results suggest that future programs devoted to mitigate the social and health effects of snakebites in the Niger Delta region should involve especially women and teenagers, with ad-hoc education projects if appropriate. We urge that international organizations working on social and health problems in the developing world, such as IRD, DFID, UNDP, should provide advice through specific programs targeted at especially these categories which have been highlighted in comparatively potential higher threat from snakebites than adult men.
DOI: 10.6084/m9.figshare.6991895.v1
title: Comparison between two methods of scorpion venom milking in Morocco

description: Background The present study compared two methods used successfully in a large-scale program for the collection of scorpion venoms, namely the milking of adult scorpions via manual and electrical stimulation. Results Our immunobiochemical characterizations clearly demonstrate that regularly applied electrical stimulation obtains scorpion venom more easily and, most importantly, in greater quantity. Qualitatively, the electrically collected venom showed lack of hemolymph contaminants such as hemocyanin. In contrast, manual obtainment of venom subjects scorpions to maximal trauma, leading to hemocyanin secretion. Our study highlighted the importance of reducing scorpion trauma during venom milking. Conclusions In conclusion, to produce high quality antivenom with specific antibodies, it is necessary to collect venom by the gentler electrical stimulation method.
DOI: 10.6084/m9.figshare.6991889.v1
title: Correlation between annual activity patterns of venomous snakes and rural people in the Niger Delta, southern Nigeria

description: Background Venomous snakes are among the most serious health hazards for rural people in tropical regions of the world. Herein we compare the monthly activity patterns of eight venomous snake species (Elapidae and Viperidae) with those of rural people in the Niger Delta area of southern Nigeria, in order to identify the periods of highest potential risk for persons, and the human group actually at greater risk of snakebite. Results We documented that above-ground activity of all venomous snakes peaked in the wet season, and that high snake activity and high human activity were most highly correlated between April and August. In addition, we documented that women and teenagers were at relatively higher risk of encountering a venomous snake than adult males, despite they are less often in the field than men. Conclusions Our results suggest that future programs devoted to mitigate the social and health effects of snakebites in the Niger Delta region should involve especially women and teenagers, with ad-hoc education projects if appropriate. We urge that international organizations working on social and health problems in the developing world, such as IRD, DFID, UNDP, should provide advice through specific programs targeted at especially these categories which have been highlighted in comparatively potential higher threat from snakebites than adult men.
DOI: 10.6084/m9.figshare.6991880
title: Use of antivenoms for the treatment of envenomation by Elapidae snakes in Guinea, Sub-Saharan Africa

description: Background In Guinea Elapids are responsible for 20% of envenomations. The associated case fatality rate (CFR) ranged 15-27%, irrespective of treatment. Results We studied 77 neurotoxic envenomations divided in 3 groups: a set of patients that received only traditional or symptomatic treatments, and two other groups that received either 2 or 4 initial vials of Antivipmyn® Africa renewed as necessary. CFR was 27.3%, 15.4% and 17.6%, respectively. Although antivenom treatment was likely to reduce CFR, it didn’t seem to have an obvious clinical benefit for the patients, suggesting a low treatment efficacy. Mean delay to treatment or clinical stages were not significantly different between the patients who recovered and the patients who died, or between groups. Interpretation of these results is complicated by the lack of systematic studies under comparable conditions. Of particular importance is the absence of assisted ventilation, available to patients in all the other clinical studies of neurotoxic envenomation. Conclusion The apparent lack of clinical benefit may have several causes. The hypothesis of a limited therapeutic window, i.e. an insufficient formation of antigen-antibody complexes once toxins are bound to their targets and/or distributed beyond the reach of antivenom, should be explored.