cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.30857531
title: Supplementary Material for: Generalized Pustular Psoriasis Confers Increased Risk of Pyoderma Gangrenosum: First Population-Based Evidence

description: Introduction: 
Generalized pustular psoriasis (GPP) and pyoderma gangrenosum (PG) are rare, severe neutrophilic dermatoses with overlapping autoinflammatory pathways. Although case reports suggest a link between GPP and PG, no populationbased studies have quantified this risk. 

Methods: 
We performed a retrospective cohort study using the TriNetX federated electronic health record network. Adults (≥18 years) with ICD10 codes for GPP (L40.1) or nonGPP psoriasis (L40.0–L40.9 excluding L40.1) from 2018–2023 were identified. Controls had no psoriasis diagnosis. Cohorts were 1:1 propensityscore matched for age, sex, race, ulcerative colitis, Crohn’s disease, systemic lupus erythematosus, and rheumatoid arthritis. The primary outcome was new PG diagnosis (L88) postindex. Hazard ratios (HRs) for PG were estimated via matched survival analysis. 

Results: 
After matching, the GPP cohort (n = 44,187) had a significantly higher risk of PG than controls (n = 44,187; HR 5.14; 95% CI 2.77–9.53). NonGPP psoriasis patients (n = 393,833) also showed elevated PG risk versus controls (n = 393,833; HR 3.83; 95% CI 3.00–4.90). In direct comparison (n = 193,208 each), GPP had greater PG risk than nonGPP psoriasis (HR 2.33; 95% CI 1.46–3.71). Median followup ranged from 687 to 886 days across comparisons. 

Conclusion: 
This first populationbased evidence demonstrates that GPP confers a markedly increased risk of PG compared to both controls and other psoriasis subtypes. These findings underscore the need for heightened clinical vigilance for PG in GPP patients and may inform targeted surveillance strategies.
DOI: 10.6084/m9.figshare.30857531.v1
title: Supplementary Material for: Generalized Pustular Psoriasis Confers Increased Risk of Pyoderma Gangrenosum: First Population-Based Evidence

description: Introduction: 
Generalized pustular psoriasis (GPP) and pyoderma gangrenosum (PG) are rare, severe neutrophilic dermatoses with overlapping autoinflammatory pathways. Although case reports suggest a link between GPP and PG, no populationbased studies have quantified this risk. 

Methods: 
We performed a retrospective cohort study using the TriNetX federated electronic health record network. Adults (≥18 years) with ICD10 codes for GPP (L40.1) or nonGPP psoriasis (L40.0–L40.9 excluding L40.1) from 2018–2023 were identified. Controls had no psoriasis diagnosis. Cohorts were 1:1 propensityscore matched for age, sex, race, ulcerative colitis, Crohn’s disease, systemic lupus erythematosus, and rheumatoid arthritis. The primary outcome was new PG diagnosis (L88) postindex. Hazard ratios (HRs) for PG were estimated via matched survival analysis. 

Results: 
After matching, the GPP cohort (n = 44,187) had a significantly higher risk of PG than controls (n = 44,187; HR 5.14; 95% CI 2.77–9.53). NonGPP psoriasis patients (n = 393,833) also showed elevated PG risk versus controls (n = 393,833; HR 3.83; 95% CI 3.00–4.90). In direct comparison (n = 193,208 each), GPP had greater PG risk than nonGPP psoriasis (HR 2.33; 95% CI 1.46–3.71). Median followup ranged from 687 to 886 days across comparisons. 

Conclusion: 
This first populationbased evidence demonstrates that GPP confers a markedly increased risk of PG compared to both controls and other psoriasis subtypes. These findings underscore the need for heightened clinical vigilance for PG in GPP patients and may inform targeted surveillance strategies.
DOI: 10.6084/m9.figshare.30857534
title: Supplementary Material for: Feasibility and effectiveness of liver transplantation following immunotherapy patients with hepatocellular carcinoma

description: Introduction: Immunotherapy is an attractive strategy for downstaging/bridging treatment of hepatocellular carcinoma (HCC) before liver transplantation (LT). This multicentre study reports the feasibility and effectiveness of LT following immunotherapy in a French HCC cohort.
Methods: Clinical, biological, and radiological data were collected at the start and end of immunotherapy, and before LT. Outcomes were evaluated through radiological response post-immunotherapy, recurrence risk (R3-AFP score) on explanted livers, and post-LT complications, aiming to assess primary LT success, overall and disease-free survival. 
Results: Twenty-one HCC patients [17 males; median age 62 years (57-64)] were included in the study. Fourteen patients (66.7%) were BCLC-B, and sixteen (76.2%) received atezolizumab/bevacizumab [median 8.5 cycles (4.7 – 14)]. At the end of immunotherapy, 57.1% met Milan-in criteria, and 95.2% had AFP score 2 (p = 0.002). The median interval from last immunotherapy to LT was 5.1 (2.7-9.3) months. All but three patients received standard immunosuppression. Explant pathology showed residual tumours in 71.4%, with 47.6% at high recurrence risk according to R3-AFP score. Two patients experienced allograft rejection, and one (4.8%) had HCC recurrence post-LT. Early adverse events occurred in 6 patients (28.5%), leading to 5 deaths (23.8%). At 12 months, 71.4% were alive without HCC recurrence. Lower overall survival was linked to pre-LT Child-Pugh B class, absence of prior HCC treatment, fewer than 5 immunotherapy cycles, and early post-LT complications. 
Conclusion: LT following immunotherapy is feasible in selected HCC patients, although caution is warranted due to the potential but manageable rejection risk. However, high early mortality warrants further investigation in larger prospective series.
DOI: 10.6084/m9.figshare.30857534.v1
title: Supplementary Material for: Feasibility and effectiveness of liver transplantation following immunotherapy patients with hepatocellular carcinoma

description: Introduction: Immunotherapy is an attractive strategy for downstaging/bridging treatment of hepatocellular carcinoma (HCC) before liver transplantation (LT). This multicentre study reports the feasibility and effectiveness of LT following immunotherapy in a French HCC cohort.
Methods: Clinical, biological, and radiological data were collected at the start and end of immunotherapy, and before LT. Outcomes were evaluated through radiological response post-immunotherapy, recurrence risk (R3-AFP score) on explanted livers, and post-LT complications, aiming to assess primary LT success, overall and disease-free survival. 
Results: Twenty-one HCC patients [17 males; median age 62 years (57-64)] were included in the study. Fourteen patients (66.7%) were BCLC-B, and sixteen (76.2%) received atezolizumab/bevacizumab [median 8.5 cycles (4.7 – 14)]. At the end of immunotherapy, 57.1% met Milan-in criteria, and 95.2% had AFP score 2 (p = 0.002). The median interval from last immunotherapy to LT was 5.1 (2.7-9.3) months. All but three patients received standard immunosuppression. Explant pathology showed residual tumours in 71.4%, with 47.6% at high recurrence risk according to R3-AFP score. Two patients experienced allograft rejection, and one (4.8%) had HCC recurrence post-LT. Early adverse events occurred in 6 patients (28.5%), leading to 5 deaths (23.8%). At 12 months, 71.4% were alive without HCC recurrence. Lower overall survival was linked to pre-LT Child-Pugh B class, absence of prior HCC treatment, fewer than 5 immunotherapy cycles, and early post-LT complications. 
Conclusion: LT following immunotherapy is feasible in selected HCC patients, although caution is warranted due to the potential but manageable rejection risk. However, high early mortality warrants further investigation in larger prospective series.
DOI: 10.34740/kaggle/dsv/14103903
title: Peer-to-Peer Boliviano (BOB) Exchange Data
DOI: 10.6084/m9.figshare.30857537
title: Supplementary Material for: Familial Annular Erythema Effectively Responded to Phototherapy: A Case Report of an Extremely Rare Entity and Literature Review

description: Background: Familial annular erythema is the inherited form of erythema annular centrifugum, in an autosomal dominant fashion. It is an extremely rare cutaneous condition characterized by asymptomatic or mildly itchy annular, arcuate or polycyclic erythematous plaques that appears few days after birth with no systemic manifestaions. Histopathological features are consistent with erythema annular centrifugum. To this date, only five families have been reported to the literature. Case presentation: Herein, we report a family with three generations of affected individuals. The index patient was a 23-year-old female, presented with mildly itchy non-scaly annular and arcuate erythematous plaques that appread since birth. Her paternal grandmother, father, sister and two male cousins have similar condition. Review of system and laboratory work-up was unremarkable. Skin biopsy showed focal compact orthohyperakeratosis, spongiosis, basal cell degeneration, porminent papillary edema with moderate superficial and deep perivascular eosinophilic infiltrate. The index patient was started on narrowband ultraviolet B therapy and showed complete clearance for at least three months. Conclusion: This extremely rare entity is not known to be associated with other organ involvement, apart from the skin. It poses diagnostic difficulty as it resembles other annular conditions during infancy. The presence of similar cases within her family underscores the genetic component of this condition, warranting further investigation and discussion. Possible effective therapeutic options include phototherapy.
DOI: 10.6084/m9.figshare.30857537.v1
title: Supplementary Material for: Familial Annular Erythema Effectively Responded to Phototherapy: A Case Report of an Extremely Rare Entity and Literature Review

description: Background: Familial annular erythema is the inherited form of erythema annular centrifugum, in an autosomal dominant fashion. It is an extremely rare cutaneous condition characterized by asymptomatic or mildly itchy annular, arcuate or polycyclic erythematous plaques that appears few days after birth with no systemic manifestaions. Histopathological features are consistent with erythema annular centrifugum. To this date, only five families have been reported to the literature. Case presentation: Herein, we report a family with three generations of affected individuals. The index patient was a 23-year-old female, presented with mildly itchy non-scaly annular and arcuate erythematous plaques that appread since birth. Her paternal grandmother, father, sister and two male cousins have similar condition. Review of system and laboratory work-up was unremarkable. Skin biopsy showed focal compact orthohyperakeratosis, spongiosis, basal cell degeneration, porminent papillary edema with moderate superficial and deep perivascular eosinophilic infiltrate. The index patient was started on narrowband ultraviolet B therapy and showed complete clearance for at least three months. Conclusion: This extremely rare entity is not known to be associated with other organ involvement, apart from the skin. It poses diagnostic difficulty as it resembles other annular conditions during infancy. The presence of similar cases within her family underscores the genetic component of this condition, warranting further investigation and discussion. Possible effective therapeutic options include phototherapy.
DOI: 10.6084/m9.figshare.30857543
title: Supplementary Material for: Physical activity is inversely associated with clinical exacerbation in patients with Crohn's disease in remission - a prospective cohort study

description: Introduction: Physical activity (PA) is associated with improved quality of life in patients with Crohn’s disease (CD). However, evidence of its impact on the clinical course of the disease remains limited. We aimed to evaluate the association between PA and relapse incidence in patients with CD in clinical remission and its association with patient-reported outcome measures. 
Methods: A prospective cohort study of adult patients with CD in clinical remission followed for one year or until relapse. At baseline, participants completed PA and nutritional questionnaires, and a patient-reported outcomes measurement information system. Multivariable Cox proportional hazards models assessed the association between PA and relapse risk, adjusted for confounders including fecal calprotectin.
Results: A total of 106 patients (mean age 37.9±13.9 years) were followed for 9.9±3.2 months, during which 23 (21.7%) experienced clinical relapse. PA at least twice a week was associated with a reduced risk of relapse (HR=0.26, 95% CI 0.09–0.79). Specifically, only aerobic activity was significantly associated with a reduced risk of relapse (HR=0.31, 95% CI 0.10-0.95). High-resistance PA was significantly associated with better quality of life parameters, including pain interference (P=0.013), sleep disturbance (P=0.040), physical function (P=0.029), and social roles (P=0.020). While aerobic PA showed benefit in physical function (P=0.016). 
Conclusions: PA in general and specifically aerobic PA, is associated with a reduced risk of relapse in patients with CD in remission, while resistance PA is associated with a better quality of life. These findings highlight the importance of incorporating PA into CD management in remission state.
DOI: 10.6084/m9.figshare.30857543.v1
title: Supplementary Material for: Physical activity is inversely associated with clinical exacerbation in patients with Crohn's disease in remission - a prospective cohort study

description: Introduction: Physical activity (PA) is associated with improved quality of life in patients with Crohn’s disease (CD). However, evidence of its impact on the clinical course of the disease remains limited. We aimed to evaluate the association between PA and relapse incidence in patients with CD in clinical remission and its association with patient-reported outcome measures. 
Methods: A prospective cohort study of adult patients with CD in clinical remission followed for one year or until relapse. At baseline, participants completed PA and nutritional questionnaires, and a patient-reported outcomes measurement information system. Multivariable Cox proportional hazards models assessed the association between PA and relapse risk, adjusted for confounders including fecal calprotectin.
Results: A total of 106 patients (mean age 37.9±13.9 years) were followed for 9.9±3.2 months, during which 23 (21.7%) experienced clinical relapse. PA at least twice a week was associated with a reduced risk of relapse (HR=0.26, 95% CI 0.09–0.79). Specifically, only aerobic activity was significantly associated with a reduced risk of relapse (HR=0.31, 95% CI 0.10-0.95). High-resistance PA was significantly associated with better quality of life parameters, including pain interference (P=0.013), sleep disturbance (P=0.040), physical function (P=0.029), and social roles (P=0.020). While aerobic PA showed benefit in physical function (P=0.016). 
Conclusions: PA in general and specifically aerobic PA, is associated with a reduced risk of relapse in patients with CD in remission, while resistance PA is associated with a better quality of life. These findings highlight the importance of incorporating PA into CD management in remission state.
DOI: 10.6084/m9.figshare.30857546
title: Supplementary Material for: A systematic review of the current trends and future directions of high-intensity focused ultrasound (HIFU) in neurosurgery

description: Background and Objectives: High-Intensity Focused Ultrasound (HIFU) has evolved significantly since its introduction to neurosurgery over 15 years ago. In the past decade, its clinical use has expanded to treat a broader range of surgical domains and indications. However, the pace and pattern of this evolution remain poorly characterized within the literature. This systematic review aims to synthesize global research on HIFU in neurosurgery over the past ten years, identifying trends across indications and regions.
Methods: Following PRISMA guidelines, we identified clinical studies involving HIFU in neurosurgical practice from January 1, 2014, to November 1, 2024. Studies were categorized by application and country of origin, and a quantitative analysis was performed to assess distribution and trends in these factors.
Results: A total of 498 studies were included. Research output increased over the period, from 13 studies in 2014 to 92 in 2024. While the scope of clinical applications expanded from 6 to 13 domains over this period, a disparity in research volume persisted, with movement disorders—particularly essential tremor (62.0%) and Parkinson’s disease (29.9%)— accounting for the majority of publications. Nonetheless, growth was observed in previously underrepresented domains such as neurooncology, psychiatry, epilepsy, chronic pain, and neurovascular disorders. Geographically, the United States accounted for the largest share of publications (38.4%), followed by Switzerland (11.6%) and the United Kingdom (8.2%). Over this period, study quality improved with a shift from case reports and pilot studies toward an increasing number of cohort studies and randomized controlled trials.
Conclusion: This review outlines the accelerating, yet uneven, exploration of HIFU in neurosurgical practice over the past decade. While movement disorders remain the central focus of this technology, expanding interest in underexplored indications indicates a shifting landscape. At the same time, the maturation of study designs reflects a strengthening evidence base. As the field advances, increased global collaboration and greater attention to budding applications are necessary.
DOI: 10.6084/m9.figshare.30857546.v1
title: Supplementary Material for: A systematic review of the current trends and future directions of high-intensity focused ultrasound (HIFU) in neurosurgery

description: Background and Objectives: High-Intensity Focused Ultrasound (HIFU) has evolved significantly since its introduction to neurosurgery over 15 years ago. In the past decade, its clinical use has expanded to treat a broader range of surgical domains and indications. However, the pace and pattern of this evolution remain poorly characterized within the literature. This systematic review aims to synthesize global research on HIFU in neurosurgery over the past ten years, identifying trends across indications and regions.
Methods: Following PRISMA guidelines, we identified clinical studies involving HIFU in neurosurgical practice from January 1, 2014, to November 1, 2024. Studies were categorized by application and country of origin, and a quantitative analysis was performed to assess distribution and trends in these factors.
Results: A total of 498 studies were included. Research output increased over the period, from 13 studies in 2014 to 92 in 2024. While the scope of clinical applications expanded from 6 to 13 domains over this period, a disparity in research volume persisted, with movement disorders—particularly essential tremor (62.0%) and Parkinson’s disease (29.9%)— accounting for the majority of publications. Nonetheless, growth was observed in previously underrepresented domains such as neurooncology, psychiatry, epilepsy, chronic pain, and neurovascular disorders. Geographically, the United States accounted for the largest share of publications (38.4%), followed by Switzerland (11.6%) and the United Kingdom (8.2%). Over this period, study quality improved with a shift from case reports and pilot studies toward an increasing number of cohort studies and randomized controlled trials.
Conclusion: This review outlines the accelerating, yet uneven, exploration of HIFU in neurosurgical practice over the past decade. While movement disorders remain the central focus of this technology, expanding interest in underexplored indications indicates a shifting landscape. At the same time, the maturation of study designs reflects a strengthening evidence base. As the field advances, increased global collaboration and greater attention to budding applications are necessary.
DOI: 10.15468/dl.8y9avg
title: Occurrence Download

description: A dataset containing 626 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Agiortia"
 ]
}

 The dataset includes 626 records from 27 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0046502-251120083545085/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.xmd972
title: Occurrence Download

description: A dataset containing 2844 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is China",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "TaxonKey is one of (Erthesina fullo, Halyomorpha halys, Cryptotympana atrata, Riptortus pedestris, Hyalessa maculaticollis, Aquarius paludum)",
 "Year 2005-2024"
 ]
}

 The dataset includes 2844 records from 5 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0046503-251120083545085/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.5281/zenodo.17878870
title: UAV-acquired orthomosaics of Loviisa shoreline outcrops

description: This dataset contains photogrammetrically generated orthomosaics of shoreline outcrops at Loviisa, South-East Finland. We used a drone to photograph the outcrops from a flight altitude of 20 m. We processed the photographs into theorthomosaics using Agisoft Photoscan software. We used up to 10 ground controlpoints to accurately georeference the orthomosaics. The resulting orthomosaicshave a ground sampling distance of 0.55 cm / pixel.

Coordinate system ETRS:3067, ETRS-TM35FIN and the data is provided as GeoTIFF (.tif) and png files (pngs added 1.3.2023). Note that the KL2 tif original has been split into two png files (KL2_1 and KL2_2).

The photos were taken and processed as part of a Geological Survey ofFinland project, KYT KARIKKO, with funding from Finnish National Nuclear WasteManagement Fund (KYT) during the summer of 2019.

Changelog:

added DEM tiffs in ./dems from the same outcrops along with a reprocessed orthomosaic for OG1 (tifs/OG1_DEM_2024.tif) 11.12.2025

pngs changed to 8-bit 26.5.2023

pngs added 1.3.2023
DOI: 10.5281/zenodo.7077518
title: UAV-acquired orthomosaics of Loviisa shoreline outcrops

description: This dataset contains photogrammetrically generated orthomosaics of shoreline outcrops at Loviisa, South-East Finland. We used a drone to photograph the outcrops from a flight altitude of 20 m. We processed the photographs into theorthomosaics using Agisoft Photoscan software. We used up to 10 ground controlpoints to accurately georeference the orthomosaics. The resulting orthomosaicshave a ground sampling distance of 0.55 cm / pixel.

Coordinate system ETRS:3067, ETRS-TM35FIN and the data is provided as GeoTIFF (.tif) and png files (pngs added 1.3.2023). Note that the KL2 tif original has been split into two png files (KL2_1 and KL2_2).

The photos were taken and processed as part of a Geological Survey ofFinland project, KYT KARIKKO, with funding from Finnish National Nuclear WasteManagement Fund (KYT) during the summer of 2019.

Changelog:

added DEM tiffs in ./dems from the same outcrops along with a reprocessed orthomosaic for OG1 (tifs/OG1_DEM_2024.tif) 11.12.2025

pngs changed to 8-bit 26.5.2023

pngs added 1.3.2023
DOI: 10.15151/esrf-es-2269609034
title: Effect of ligand binding motifs on colloidal CdSe morphology and exciton emission

description: Investigation of phosphonate ligand binding motifs on ultrathin colloidal CdSe. Correlation between morphology and exciton emission will be investigated using coupled time-resolved SAXS/WAXS and UV-Vis absorption spectroscopy.
DOI: 10.6084/m9.figshare.30857525
title: Sequencing data of "Pulpal Pressure Aggravates Pulpitis by Mechano-Inflammatory Signal Synergy"

description: Sequencing data of "Pulpal Pressure Aggravates Pulpitis by Mechano-Inflammatory Signal Synergy"