cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.24935577
title: Two-step data: Experiment 1 VEH post-TR

description: Manuscript abstract: Psychedelic drugs can aid fast and lasting remission from various neuropsychiatric disorders, though the underlying mechanisms remain unclear. Preclinical studies suggest serotonergic psychedelics enhance neuronal plasticity, but whether neuroplastic changes can also be seen at cognitive and behavioural levels is unexplored. Here we show that a single dose of the psychedelic 2,5-dimethoxy-4-iodoamphetamine ((±)-DOI) affects structural brain plasticity and cognitive flexibility in young adult mice beyond the acute drug experience. Using ex vivo magnetic resonance imaging, we show increased volumes of several sensory and association areas one day after systemic administration of 2mgkg-1 (±)-DOI. We then demonstrate lasting effects of (±)-DOI on cognitive flexibility in a two-step probabilistic reversal learning task where 2mgkg-1 (±)-DOI improved the rate of adaptation to a novel reversal in task structure occurring one-week post-treatment. Strikingly, (±)-DOI-treated mice started learning from reward omissions, a unique strategy not typically seen in mice in this task, suggesting heightened sensitivity to previously overlooked cues. Crucially, further experiments revealed that (±)-DOI’s effects on cognitive flexibility were contingent on the timing between drug treatment and the novel reversal, as well as on the nature of the intervening experience. (±)-DOI’s facilitation of both cognitive adaptation and novel thinking strategies may contribute to the clinical benefits of psychedelic-assisted therapy, particularly in cases of perseverative behaviours and a resistance to change seen in depression, anxiety, or addiction. Furthermore, our findings highlight the crucial role of time-dependent neuroplasticity and the influence of experiential factors in shaping the therapeutic potential of psychedelic interventions for impaired cognitive flexibility.
DOI: 10.6084/m9.figshare.24935577.v1
title: Two-step data: Experiment 1 VEH post-TR

description: Manuscript abstract: Psychedelic drugs can aid fast and lasting remission from various neuropsychiatric disorders, though the underlying mechanisms remain unclear. Preclinical studies suggest serotonergic psychedelics enhance neuronal plasticity, but whether neuroplastic changes can also be seen at cognitive and behavioural levels is unexplored. Here we show that a single dose of the psychedelic 2,5-dimethoxy-4-iodoamphetamine ((±)-DOI) affects structural brain plasticity and cognitive flexibility in young adult mice beyond the acute drug experience. Using ex vivo magnetic resonance imaging, we show increased volumes of several sensory and association areas one day after systemic administration of 2mgkg-1 (±)-DOI. We then demonstrate lasting effects of (±)-DOI on cognitive flexibility in a two-step probabilistic reversal learning task where 2mgkg-1 (±)-DOI improved the rate of adaptation to a novel reversal in task structure occurring one-week post-treatment. Strikingly, (±)-DOI-treated mice started learning from reward omissions, a unique strategy not typically seen in mice in this task, suggesting heightened sensitivity to previously overlooked cues. Crucially, further experiments revealed that (±)-DOI’s effects on cognitive flexibility were contingent on the timing between drug treatment and the novel reversal, as well as on the nature of the intervening experience. (±)-DOI’s facilitation of both cognitive adaptation and novel thinking strategies may contribute to the clinical benefits of psychedelic-assisted therapy, particularly in cases of perseverative behaviours and a resistance to change seen in depression, anxiety, or addiction. Furthermore, our findings highlight the crucial role of time-dependent neuroplasticity and the influence of experiential factors in shaping the therapeutic potential of psychedelic interventions for impaired cognitive flexibility.
DOI: 10.6084/m9.figshare.24935607
title: Two-step data: Experiment 1 DOI pre-drug

description: Manuscript abstract: Psychedelic drugs can aid fast and lasting remission from various neuropsychiatric disorders, though the underlying mechanisms remain unclear. Preclinical studies suggest serotonergic psychedelics enhance neuronal plasticity, but whether neuroplastic changes can also be seen at cognitive and behavioural levels is unexplored. Here we show that a single dose of the psychedelic 2,5-dimethoxy-4-iodoamphetamine ((±)-DOI) affects structural brain plasticity and cognitive flexibility in young adult mice beyond the acute drug experience. Using ex vivo magnetic resonance imaging, we show increased volumes of several sensory and association areas one day after systemic administration of 2mgkg-1 (±)-DOI. We then demonstrate lasting effects of (±)-DOI on cognitive flexibility in a two-step probabilistic reversal learning task where 2mgkg-1 (±)-DOI improved the rate of adaptation to a novel reversal in task structure occurring one-week post-treatment. Strikingly, (±)-DOI-treated mice started learning from reward omissions, a unique strategy not typically seen in mice in this task, suggesting heightened sensitivity to previously overlooked cues. Crucially, further experiments revealed that (±)-DOI’s effects on cognitive flexibility were contingent on the timing between drug treatment and the novel reversal, as well as on the nature of the intervening experience. (±)-DOI’s facilitation of both cognitive adaptation and novel thinking strategies may contribute to the clinical benefits of psychedelic-assisted therapy, particularly in cases of perseverative behaviours and a resistance to change seen in depression, anxiety, or addiction. Furthermore, our findings highlight the crucial role of time-dependent neuroplasticity and the influence of experiential factors in shaping the therapeutic potential of psychedelic interventions for impaired cognitive flexibility.
DOI: 10.6084/m9.figshare.24935607.v1
title: Two-step data: Experiment 1 DOI pre-drug

description: Manuscript abstract: Psychedelic drugs can aid fast and lasting remission from various neuropsychiatric disorders, though the underlying mechanisms remain unclear. Preclinical studies suggest serotonergic psychedelics enhance neuronal plasticity, but whether neuroplastic changes can also be seen at cognitive and behavioural levels is unexplored. Here we show that a single dose of the psychedelic 2,5-dimethoxy-4-iodoamphetamine ((±)-DOI) affects structural brain plasticity and cognitive flexibility in young adult mice beyond the acute drug experience. Using ex vivo magnetic resonance imaging, we show increased volumes of several sensory and association areas one day after systemic administration of 2mgkg-1 (±)-DOI. We then demonstrate lasting effects of (±)-DOI on cognitive flexibility in a two-step probabilistic reversal learning task where 2mgkg-1 (±)-DOI improved the rate of adaptation to a novel reversal in task structure occurring one-week post-treatment. Strikingly, (±)-DOI-treated mice started learning from reward omissions, a unique strategy not typically seen in mice in this task, suggesting heightened sensitivity to previously overlooked cues. Crucially, further experiments revealed that (±)-DOI’s effects on cognitive flexibility were contingent on the timing between drug treatment and the novel reversal, as well as on the nature of the intervening experience. (±)-DOI’s facilitation of both cognitive adaptation and novel thinking strategies may contribute to the clinical benefits of psychedelic-assisted therapy, particularly in cases of perseverative behaviours and a resistance to change seen in depression, anxiety, or addiction. Furthermore, our findings highlight the crucial role of time-dependent neuroplasticity and the influence of experiential factors in shaping the therapeutic potential of psychedelic interventions for impaired cognitive flexibility.
DOI: 10.5281/zenodo.10305345
title: Categorización de resultados

description: Los resultados del estudio categorizados por pregunta de investigación y subcategorías
DOI: 10.5281/zenodo.10305346
title: Categorización de resultados
DOI: 10.5281/zenodo.10351445
title: Categorización de resultados

description: Los resultados del estudio categorizados por pregunta de investigación y subcategorías
DOI: 10.5281/zenodo.10453433
title: Categorización de resultados

description: Los resultados del estudio categorizados por pregunta de investigación y subcategorías
DOI: 10.6084/m9.figshare.24935613
title: Two-step data: Experiment 1 DOI post-drug

description: Manuscript abstract: Psychedelic drugs can aid fast and lasting remission from various neuropsychiatric disorders, though the underlying mechanisms remain unclear. Preclinical studies suggest serotonergic psychedelics enhance neuronal plasticity, but whether neuroplastic changes can also be seen at cognitive and behavioural levels is unexplored. Here we show that a single dose of the psychedelic 2,5-dimethoxy-4-iodoamphetamine ((±)-DOI) affects structural brain plasticity and cognitive flexibility in young adult mice beyond the acute drug experience. Using ex vivo magnetic resonance imaging, we show increased volumes of several sensory and association areas one day after systemic administration of 2mgkg-1 (±)-DOI. We then demonstrate lasting effects of (±)-DOI on cognitive flexibility in a two-step probabilistic reversal learning task where 2mgkg-1 (±)-DOI improved the rate of adaptation to a novel reversal in task structure occurring one-week post-treatment. Strikingly, (±)-DOI-treated mice started learning from reward omissions, a unique strategy not typically seen in mice in this task, suggesting heightened sensitivity to previously overlooked cues. Crucially, further experiments revealed that (±)-DOI’s effects on cognitive flexibility were contingent on the timing between drug treatment and the novel reversal, as well as on the nature of the intervening experience. (±)-DOI’s facilitation of both cognitive adaptation and novel thinking strategies may contribute to the clinical benefits of psychedelic-assisted therapy, particularly in cases of perseverative behaviours and a resistance to change seen in depression, anxiety, or addiction. Furthermore, our findings highlight the crucial role of time-dependent neuroplasticity and the influence of experiential factors in shaping the therapeutic potential of psychedelic interventions for impaired cognitive flexibility.
DOI: 10.6084/m9.figshare.24935613.v1
title: Two-step data: Experiment 1 DOI post-drug

description: Manuscript abstract: Psychedelic drugs can aid fast and lasting remission from various neuropsychiatric disorders, though the underlying mechanisms remain unclear. Preclinical studies suggest serotonergic psychedelics enhance neuronal plasticity, but whether neuroplastic changes can also be seen at cognitive and behavioural levels is unexplored. Here we show that a single dose of the psychedelic 2,5-dimethoxy-4-iodoamphetamine ((±)-DOI) affects structural brain plasticity and cognitive flexibility in young adult mice beyond the acute drug experience. Using ex vivo magnetic resonance imaging, we show increased volumes of several sensory and association areas one day after systemic administration of 2mgkg-1 (±)-DOI. We then demonstrate lasting effects of (±)-DOI on cognitive flexibility in a two-step probabilistic reversal learning task where 2mgkg-1 (±)-DOI improved the rate of adaptation to a novel reversal in task structure occurring one-week post-treatment. Strikingly, (±)-DOI-treated mice started learning from reward omissions, a unique strategy not typically seen in mice in this task, suggesting heightened sensitivity to previously overlooked cues. Crucially, further experiments revealed that (±)-DOI’s effects on cognitive flexibility were contingent on the timing between drug treatment and the novel reversal, as well as on the nature of the intervening experience. (±)-DOI’s facilitation of both cognitive adaptation and novel thinking strategies may contribute to the clinical benefits of psychedelic-assisted therapy, particularly in cases of perseverative behaviours and a resistance to change seen in depression, anxiety, or addiction. Furthermore, our findings highlight the crucial role of time-dependent neuroplasticity and the influence of experiential factors in shaping the therapeutic potential of psychedelic interventions for impaired cognitive flexibility.
DOI: 10.6084/m9.figshare.24935628
title: Two-step data: Experiment 1 DOI post-TR

description: Manuscript abstract: Psychedelic drugs can aid fast and lasting remission from various neuropsychiatric disorders, though the underlying mechanisms remain unclear. Preclinical studies suggest serotonergic psychedelics enhance neuronal plasticity, but whether neuroplastic changes can also be seen at cognitive and behavioural levels is unexplored. Here we show that a single dose of the psychedelic 2,5-dimethoxy-4-iodoamphetamine ((±)-DOI) affects structural brain plasticity and cognitive flexibility in young adult mice beyond the acute drug experience. Using ex vivo magnetic resonance imaging, we show increased volumes of several sensory and association areas one day after systemic administration of 2mgkg-1 (±)-DOI. We then demonstrate lasting effects of (±)-DOI on cognitive flexibility in a two-step probabilistic reversal learning task where 2mgkg-1 (±)-DOI improved the rate of adaptation to a novel reversal in task structure occurring one-week post-treatment. Strikingly, (±)-DOI-treated mice started learning from reward omissions, a unique strategy not typically seen in mice in this task, suggesting heightened sensitivity to previously overlooked cues. Crucially, further experiments revealed that (±)-DOI’s effects on cognitive flexibility were contingent on the timing between drug treatment and the novel reversal, as well as on the nature of the intervening experience. (±)-DOI’s facilitation of both cognitive adaptation and novel thinking strategies may contribute to the clinical benefits of psychedelic-assisted therapy, particularly in cases of perseverative behaviours and a resistance to change seen in depression, anxiety, or addiction. Furthermore, our findings highlight the crucial role of time-dependent neuroplasticity and the influence of experiential factors in shaping the therapeutic potential of psychedelic interventions for impaired cognitive flexibility.
DOI: 10.6084/m9.figshare.24935628.v1
title: Two-step data: Experiment 1 DOI post-TR

description: Manuscript abstract: Psychedelic drugs can aid fast and lasting remission from various neuropsychiatric disorders, though the underlying mechanisms remain unclear. Preclinical studies suggest serotonergic psychedelics enhance neuronal plasticity, but whether neuroplastic changes can also be seen at cognitive and behavioural levels is unexplored. Here we show that a single dose of the psychedelic 2,5-dimethoxy-4-iodoamphetamine ((±)-DOI) affects structural brain plasticity and cognitive flexibility in young adult mice beyond the acute drug experience. Using ex vivo magnetic resonance imaging, we show increased volumes of several sensory and association areas one day after systemic administration of 2mgkg-1 (±)-DOI. We then demonstrate lasting effects of (±)-DOI on cognitive flexibility in a two-step probabilistic reversal learning task where 2mgkg-1 (±)-DOI improved the rate of adaptation to a novel reversal in task structure occurring one-week post-treatment. Strikingly, (±)-DOI-treated mice started learning from reward omissions, a unique strategy not typically seen in mice in this task, suggesting heightened sensitivity to previously overlooked cues. Crucially, further experiments revealed that (±)-DOI’s effects on cognitive flexibility were contingent on the timing between drug treatment and the novel reversal, as well as on the nature of the intervening experience. (±)-DOI’s facilitation of both cognitive adaptation and novel thinking strategies may contribute to the clinical benefits of psychedelic-assisted therapy, particularly in cases of perseverative behaviours and a resistance to change seen in depression, anxiety, or addiction. Furthermore, our findings highlight the crucial role of time-dependent neuroplasticity and the influence of experiential factors in shaping the therapeutic potential of psychedelic interventions for impaired cognitive flexibility.
DOI: 10.5281/zenodo.10408480
title: read count table of ly_111 cohort

description: Blood RNAseq read counts of rare disease and controls.  All samples were subjected to Whole Blood RNA-seq protocol and sequenced on Illumina NovaSeq 6000 platform with 150 bp paired-end reads. Total RNA was isolated with TRIzol-based RNA extraction. Quality of RNA was assessed by determination of the RNA integrity number (RIN) with a Bioanalyzer (Agilent). Next, polyadenylated RNA (mainly mRNA) was enriched with theNEBNext Poly(A) mRNA Magnetic Isolation Module (NEB, USA) followed by fragmentation, cDNA synthesis and library construction with the NEBNext Ultra™ II RNA Library Prep Kit for Illumina (NEB, USA). A minimum of 50 million reads were generated per sample. FASTQ files were processed with an inhouse pipeline. Raw reads were cleaned with fastp (v0.20.0), mapped with HiSat2 (v.2.1.0) to the GRCh38 GENCODE genome assembly and Gencode v41 as transcriptome reference. SNPs and indels were called using the GATK short variant discovery recommended pipeline with GATK (4.1.3.0) and STAR (2.5.3).
DOI: 10.5281/zenodo.10408481
title: read count table of ly_111 cohort

description: Blood RNAseq read counts of rare disease and controls.  All samples were subjected to Whole Blood RNA-seq protocol and sequenced on Illumina NovaSeq 6000 platform with 150 bp paired-end reads. Total RNA was isolated with TRIzol-based RNA extraction. Quality of RNA was assessed by determination of the RNA integrity number (RIN) with a Bioanalyzer (Agilent). Next, polyadenylated RNA (mainly mRNA) was enriched with theNEBNext Poly(A) mRNA Magnetic Isolation Module (NEB, USA) followed by fragmentation, cDNA synthesis and library construction with the NEBNext Ultra™ II RNA Library Prep Kit for Illumina (NEB, USA). A minimum of 50 million reads were generated per sample. FASTQ files were processed with an inhouse pipeline. Raw reads were cleaned with fastp (v0.20.0), mapped with HiSat2 (v.2.1.0) to the GRCh38 GENCODE genome assembly and Gencode v41 as transcriptome reference. SNPs and indels were called using the GATK short variant discovery recommended pipeline with GATK (4.1.3.0) and STAR (2.5.3).
DOI: 10.6084/m9.figshare.24935604
title: COLARE: Commit Classification via Fine-grained Context-aware Representation of Code Changes

description: code and data for the paper "COLARE: Commit Classification via Fine-grained Context-aware Representation of Code Changes
DOI: 10.6084/m9.figshare.24935604.v1
title: COLARE: Commit Classification via Fine-grained Context-aware Representation of Code Changes

description: code and data for the paper "COLARE: Commit Classification via Fine-grained Context-aware Representation of Code Changes
DOI: 10.4121/bac024f1-6c2e-4a09-bf0f-be78b6bbe21c
title: Scripts and data for "Historical shifts in seasonality and timing of extreme precipitation"

description: This dataset contains the python scripts and NetCDF data for the analyses and to recreate the figures of the manuscript: "Historical shifts in seasonality and timing of extreme precipitation" by Gaby Gründemann, Enrico Zorzetto, Nick van de Giesen, and Ruud van der Ent
DOI: 10.5281/zenodo.10201545
title: Dataset for the paper "Largest aftershock nucleation driven by afterslip during the 2014 Iquique sequence"

description: Dataset for the following paper 
Yuji Itoh, Anne Socquet, and Mathilde Radiguet, Largest aftershock nucleation driven by afterslip during the 2014 Iquique sequence, Geophysical Research Letters, 2023GL104852
See readme.txt files for details about the files and the contact informaton. Uncompressing produces files with ~ 500 MB in total.
DOI: 10.5281/zenodo.5781881
title: Tracked IMERG Mesoscale Precipitation Systems (TIMPS)

description: TIMPS is a dataset of tracked precipitation systems in the tropics derived from NASA's Integrated Multi-satellitE Retrievals for GPM (IMERG) v06B precipitation fields. TIMPS uses the Forward in Time (FiT)Tracking Algorithm and is optimized to track precipitation systems representative of Mesoscale Convective Systems (MCSs). The TIMPS domain is 30N-30S and systems are tracked across 10 years (2011-2020).
DOI: 10.5281/zenodo.6977589
title: Crystal size and texture data of sea ice from the Antarctic Marginal Ice Zone collected in Winter 2019

description: This dataset details the crystal size and texture data from the sea ice cores collected during the SCALE Winter 2019 voyage to the Antarctic Marginal Ice Zone. Each sample collected has a series of accompanying photograph figures from which the crystal size and texture are based.
DOI: 10.6084/m9.figshare.23501664
title: Multi-temporal InSAR, GNSS and seismic measurements reveal the origin of the 2021 Vulcano island (Italy) unrest

description: GNSS (Global Navigation Satellite System) and InSAR measurements related the 2021 Vulcano island (Italy) unrest
DOI: 10.4121/a926a060-d814-4d31-882d-193ecd4ce557
title: The effect of sediment transport models on simulating river dune dynamics: Model data and processing

description: This dataset contains all model data that is used to produce the output and results presented in the paper "The effect of sediment transport models on simulating river dune dynamics" by L.R. Lokin, J.J. Warmink and S.J.M.H. Hulscher, published in Water Resources Research. For a full description of the data we refer to the metadata file. For any other questions regarding the data feel free to contact the authors.
DOI: 10.5281/zenodo.10276579
title: Properties of identified ship tracks

description: The ship track database of is used, which used "day microphysics" images comprised of a composite of visible, near and thermal infrared channels were used to manually locate likely positions of ship tracks. Identification was assisted by examining the CDNC, calculated from the MYD06 level 2 cloud retrieval products from Moderate Resolution Imaging Spectroradiometer (MODIS) onboard the Aqua satellite. The CDNC is calculated based on the adiabatic assumption, using the cloud optical depth and cloud effective radius from the MODIS MYD06 level 2 product.
Ship locations were sourced from their automatic identification system (AIS) data, allowing an observed ship track to be linked to the generating ship. Local meteorology was gathered from the European Centre for Medium-Range Weather Forecasts ERA5 reanalysis data, and ships mass emission rates were calculated using their specific fuel consumption and estimated drag. 
Data labels:

trackno: Ship track identifier (-)
sox: SO emission rate (kg s^-1)
cbh: Cloud base height (m)
blh: Boundary layer height (m)
cth: Cloud top height (m)
spd_res: Relative velocity between ship velocity and wind velocity (m s^-1)
nd_cln: Background cloud droplet number concentration (cm^-3)
nd_pol: Ship track cloud droplet number concentration (cm^-3)
cf_liq: Liquid cloud fraction (-)
lwp: Liquid water path (g m^-2)
t1000: Temperature at 1000 hPa (K)
LTS: Low tropospheric stability (K)
ctt: Cloud top temperature (K)
ctrc: Cloud top radiative cooling (W m^-2)
is_coupled: Flag for cloud coupling according to cloud base height indicator (cbh<1000 m)