cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.20701305
title: A mouse-adapted CVA6 strain exhibits neurotropism and triggers systemic manifestations in a novel murine model

description: CVA6 is one of Enteroviruses causing worldwide epidemics of HFMD with neurological and systemic complications. A suitable animal model is necessary for studying the pathogenesis of CVA6 and evaluating antiviral and vaccine efficacy. In this study, we generated a mouse-adapted CVA6 strain that successfully infected 10-day-old ICR mice via oral route. All infected mice were paralyzed and died within 11 dpi. Analysis of pathological changes and virus loads in fourteen tissues showed that CVA6 triggered systematic damage similar to i.p. inoculation route. Unlike i.p. route, we detected oral and gastrointestinal lesions with the presence of viral antigens. Both specific anti-CVA6 serum and inactivated vaccines successfully generated immune protection in mice. Meanwhile, we also established a successful infection of CVA6 via i.p. and i.m. route in 10-day-old mice. After infection, mice developed remarkably neurological signs and systemic manifestations such as emaciation, polypnea, quadriplegia, depilation and even death. Through i.p. inoculation, pathological examination showed brain and spinal cord damage caused by the virus infection with neuronal reduction, apoptosis, astrocyte activation, and recruitment of neutrophils and monocytes. Following neurological manifestation, the CVA6 infection became systemic, and high viral loads were detected in multiple organs along with morphological changes and inflammation. Moreover, analysis of spleen cells by FACS indicated that CVA6 led to immune system activation, which further contributed to systemic inflammation. Taken together, our novel murine model of CVA6 provides a useful tool for studying the pathogenesis and evaluating antiviral and vaccine efficacy.
DOI: 10.6084/m9.figshare.19128709.v1
title: Additional file 1 of Single-cell analysis of mouse uterus at the invasion phase of embryo implantation

description: Additional file 1: Table S1. The complete list of novel and known marker genes for each cell type.
DOI: 10.6084/m9.figshare.19128712
title: Additional file 2 of Single-cell analysis of mouse uterus at the invasion phase of embryo implantation

description: Additional file 2: Table S2. The complete list of signature genes for stromal cell clusters.
DOI: 10.6084/m9.figshare.20701305.v2
title: A mouse-adapted CVA6 strain exhibits neurotropism and triggers systemic manifestations in a novel murine model

description: CVA6 is one of Enteroviruses causing worldwide epidemics of HFMD with neurological and systemic complications. A suitable animal model is necessary for studying the pathogenesis of CVA6 and evaluating antiviral and vaccine efficacy. In this study, we generated a mouse-adapted CVA6 strain that successfully infected 10-day-old ICR mice via oral route. All infected mice were paralyzed and died within 11 dpi. Analysis of pathological changes and virus loads in fourteen tissues showed that CVA6 triggered systematic damage similar to i.p. inoculation route. Unlike i.p. route, we detected oral and gastrointestinal lesions with the presence of viral antigens. Both specific anti-CVA6 serum and inactivated vaccines successfully generated immune protection in mice. Meanwhile, we also established a successful infection of CVA6 via i.p. and i.m. route in 10-day-old mice. After infection, mice developed remarkably neurological signs and systemic manifestations such as emaciation, polypnea, quadriplegia, depilation and even death. Through i.p. inoculation, pathological examination showed brain and spinal cord damage caused by the virus infection with neuronal reduction, apoptosis, astrocyte activation, and recruitment of neutrophils and monocytes. Following neurological manifestation, the CVA6 infection became systemic, and high viral loads were detected in multiple organs along with morphological changes and inflammation. Moreover, analysis of spleen cells by FACS indicated that CVA6 led to immune system activation, which further contributed to systemic inflammation. Taken together, our novel murine model of CVA6 provides a useful tool for studying the pathogenesis and evaluating antiviral and vaccine efficacy.
DOI: 10.6084/m9.figshare.19128715
title: Additional file 3 of Single-cell analysis of mouse uterus at the invasion phase of embryo implantation

description: Additional file 3: Table S3. The complete list of differentially expressed genes in IS compared to IIS for all cell types (logFC &gt; 0.25 and P &lt; 0.05).
DOI: 10.6084/m9.figshare.19128712.v1
title: Additional file 2 of Single-cell analysis of mouse uterus at the invasion phase of embryo implantation

description: Additional file 2: Table S2. The complete list of signature genes for stromal cell clusters.
DOI: 10.6084/m9.figshare.7594421.v1
title: Detachment of adhered particles from a cloth surface subjected to a rod strike

description: A mechanical impulse can cause adhered particles to detach from a surface. For various purposes, particle detachment may need to be enhanced or restricted. Unlike rigid solids, cloth material can be deformed or bent by a mechanical impulse. However, neither the cloth deformation nor the induced turbulent airflow has been well studied. This investigation experimentally measured the detachment of Arizona test dust (ATD) from cloth segments. The vertical margins of each cloth segment were fastened to a frame, and the cloth surface with the ATD adhered to the reverse side was struck with a rod. The cloth motion, induced airflow, and particle detachment were recorded by a high-speed camera. In addition, the displacement and acceleration of the cloth were monitored with a laser distance sensor. The mass percentages of detached particles from the cloth and the particle residual were weighed. Several factors that affected particle detachment were compared. The results revealed that the particle detachment was caused by a combination of the vibrating motion of the cloth surface, the hydrodynamic action of the induced turbulent airflows, and the particle agglomeration when the cloth was bent. A strike could even leave fewer residual particles when a much higher surface dust load had initially adhered to the cloth. Copyright © 2019 American Association for Aerosol Research
DOI: 10.6084/m9.figshare.22767443.v1
title: Additional file 1 of Transcriptomic profiling of near-isogenic lines reveals candidate genes for a significant locus conferring metribuzin resistance in wheat

description: Supplementary Material 1
DOI: 10.6084/m9.figshare.19120319.v1
title: Additional file 8 of RNA-Seq with a novel glabrous-ZM24fl reveals some key lncRNAs and the associated targets in fiber initiation of cotton

description: Additional file 8. The KEGG pathways of differentially expressed targeted genes of DELs.
DOI: 10.6084/m9.figshare.19128751.v1
title: Additional file 3 of Prediction of occult tumor progression via platelet RNAs in a mouse melanoma model: a potential new platform for early detection of cancer

description: Additional file 3: Table S10. Differentially expressed mRNAs in PBMCs of suboptimal inoculation group compared with optimal inoculation group and control group.
DOI: 10.6084/m9.figshare.19128709
title: Additional file 1 of Single-cell analysis of mouse uterus at the invasion phase of embryo implantation

description: Additional file 1: Table S1. The complete list of novel and known marker genes for each cell type.
DOI: 10.17632/v8n9jh6vwr.1
title: SUSTAINABLE ENTREPRENEURSHIP: A CATALYST FOR POVERTY ERADICATION AND ECONOMIC DEVELOPMENT

description: Abstract : 
The United Nations' 17 Sustainable Development Goals (SDGs), approved in 2015, include major objectives such as eliminating extreme poverty, ensuring universal access to enough and nutritious food by 2030, and promoting sustainable industry. The promotion of sustainable entrepreneurial development will greatly contribute to the attainment of these objectives. The primary objective of the research is to identify the components of sustainable entrepreneurship and formulate a novel framework for it. Additionally, the study aims to analyse the connections between (a) the development of entrepreneurship and the state of poverty, and (b) the sustainable development movement and increased economic growth. This study is a combination of conceptual and descriptive elements, and it relies on secondary data. In addition to reports from organisations such as the World Economic Forum, United Nations, World Bank, FAO, and media, research articles published in journals have also been taken into account. A Spearman correlation test is used to determine the association between variables. There is a little negative correlation between entrepreneurial development and poverty levels, whereas there is a modestly favourable correlation between the sustainable development movement and faster economic growth. The results would provide insight into the current understanding of sustainable entrepreneurship and its contribution to the attainment of the Sustainable Development Goals (SDGs). The current research introduces a revised model of sustainable business that aligns with the SDGs, building upon the work of several experts.
Keywords: sustainable entrepreneurship, sustainable development, economic growth, poverty reduction, SDG
1. Introduction: 
Entrepreneurship development has long been a focal point for policymakers and scholars, who have associated it with the production of wealth, job opportunities, empowerment of women, and economic progress. The concept of many types of entrepreneurship, such as social entrepreneurship, green entrepreneurship, and eco-entrepreneurship, also originated in the literature on entrepreneurship in the 1980s and 1990s. Subsequently, several categories of business endeavours have been rapidly increasing in popularity. Nevertheless, the issues pertaining to poverty, hunger, unemployment, inequality, and the absence of suitable job opportunities have yet to be resolved. The prevalence of harmful entrepreneurship, often linked to white-collar crimes, is becoming more noticeable in contemporary times (Chanu, 2014). This kind of economic progress engenders illicit affluence and exacerbates societal disparities. Moreover, the COVID-19 epidemic has precipitated the descent of hundreds of millions into abject destitution and persistent malnutrition (Sustainable Development Goals Report, 2021). The problems of pollution resulting from fast and unsustainable industrialization, coupled with inadequate creative waste management .....
DOI: 10.6084/m9.figshare.22767540.v1
title: Additional file 8 of Transcriptome-wide analysis of RNA m6A methylation regulation of muscle development in Queshan Black pigs

description: Additional file 8: Table S8. All GO terms for the DMEGs.
DOI: 10.17632/726y8hky79.1
title: Digital Ethics

description: Articolo che approfondisce gli effetti e lo stato dell'implementazione dell'IA nel mondo legale
2023
DOI: 10.6084/m9.figshare.22767540
title: Additional file 8 of Transcriptome-wide analysis of RNA m6A methylation regulation of muscle development in Queshan Black pigs

description: Additional file 8: Table S8. All GO terms for the DMEGs.
DOI: 10.17632/9d7mhxzt9g.1
title: Selective pressures of platinum compounds shape the evolution of therapy-related myeloid neoplasms

description: This repository includes all code and data that is needed to reproduce the figures from Bertrums et al. 2024 on platinum treatment and therapy-related myeloid neoplasms, including the somatic mutations, structural variants, and copy number variations found in these samples. It includes both WGS of bulk t-MN, and single cell/clone WGS used for constructing phylogenetic trees.
A comprehensive description of the data files can be found in "input_data/README".
A comprehensive description of the scripts and how to run them can be found in: "scripts/README"
DOI: 10.17632/vwkt4dyr49.1
title: Not from scratch: Explainable deep transfer learning fine-tunning with domain adaptation enables trustworthy COVID-19 prediction

description: Background and Objective: Medical image analysis can help diagnose Coronavirus Disease 2019 (COVID-19) early and save patient lives before the disease worsens. However, there are various limitations to manual inspection of these medical images, such as dependence on physician experience and subjectivity of assessment. To facilitate the rapid and accurate diagnosis of disease, computer-aided diagnostic systems based on deep learning methods, typically convolutional neural networks (CNN) can be used. However, neural networks are usually black-box models that do not provide a clear insight into their prediction outcomes.
Methods: Here, we proposed a framework called explainable deep transfer learning for medical image classification (XDTLMI-Net) that uses four CNNs proficient in handling image data, including GoogLeNet, ResNet18, ResNet50 and ResNet101. This framework uses existing medical domain knowledge to guide transfer learning with COVID-19 CT scan images and CXR images.
Results: XDTLMI-Net performed three tasks of medical image classification of COVID-19 on three benchmark datasets: COVID-19 CT, SARS-COV-2 CT and COVID-19 CXR. It achieved an average classification accuracy of 0.9897, 0.9752 and 0.9397, and an average classification F1-score of 0.9898, 0.9741 and 0.9394, respectively. Moreover, we employed the Shaply Additive exPlanations (SHAP) and gradient-weighted class activation mapping (Grad-CAM) to interpret the COVID-19 predictions and help understand the predictive models’ decision-making process.
Conclusions: A general end-to-end framework called XDTLMI-Net based on CNN and TL was developed, which works on small datasets of medical images, which does not require any segmentation or image preprocessing procedures. XDTLMI-Net outperformed on three datasets in fine-tuning course and gave reasonable importance to each input COVID-19 image, showing its potential for application in different clinical scenarios.
DOI: 10.17632/4nwjyhjs46.1
title: Virtual Touch Toolkit: My Body in Your Hands

description: Virtual Touch Toolkit: My Body in Your Hands Not all touch is pleasant with both individual and cultural differences in how affective touch is perceived How we feel about touch depends on “who” is touching me, “where” and "why". For a more nuanced understanding of affective touch, we have created a Virtual Touch Toolkit (Najm et al., 2022). This novel digital touch tool allows for ecological testing which is particularly useful within the context of touch which is a personal and often intimate experience. With it we can more specifically test context driven effects: who, where, when and what will determine how we feel about touch . The tool captures both how we like to be touched but also how we use our sense of touch. The following data is from several instances of using the "My body in your hands" exercise including large citizen science projects as well as a User experience study in which all of the touch exercises were sampled. Funded by the German Research Foundation (DFG, Deutsche Forschungsgemeinschaft) as part of Germany’s Excellence Strategy – EXC 2050/1 – Project ID 390696704 – Cluster of Excellence “Centre for Tactile Internet with Human-in-the-Loop” (CeTI) of Technische Universität Dresden.
DOI: 10.6084/m9.figshare.19128788
title: Additional file 1 of Construction and comprehensive analysis of the competing endogenous RNA network in endometrial adenocarcinoma

description: Additional file 1. Up-mRNA. Up regulation of mRNA.
DOI: 10.6084/m9.figshare.19128782.v1
title: Additional file 12 of Construction and comprehensive analysis of the competing endogenous RNA network in endometrial adenocarcinoma

description: Additional file 12. 10 hub genes. The location and function for 10 hub genes.
DOI: 10.6084/m9.figshare.19128788.v1
title: Additional file 1 of Construction and comprehensive analysis of the competing endogenous RNA network in endometrial adenocarcinoma

description: Additional file 1. Up-mRNA. Up regulation of mRNA.
DOI: 10.6084/m9.figshare.19128793
title: Additional file 5 of CENPF/CDK1 signaling pathway enhances the progression of adrenocortical carcinoma by regulating the G2/M-phase cell cycle

description: Additional file 5: Table S5. GSEA analysis of KEGG pathway.
DOI: 10.6084/m9.figshare.19128748.v1
title: Additional file 2 of Prediction of occult tumor progression via platelet RNAs in a mouse melanoma model: a potential new platform for early detection of cancer

description: Additional file 2: Table S9. Differentially expressed mRNAs in platelets of suboptimal inoculation group compared with optimal inoculation group and control group.
DOI: 10.6084/m9.figshare.19128803.v1
title: Additional file 4 of Construction and comprehensive analysis of the competing endogenous RNA network in endometrial adenocarcinoma

description: Additional file 4. Down-lncRNA. Down regulation of lncRNA.
DOI: 10.6084/m9.figshare.20177268.v1
title: Pathological stage-associated non-coding RNA long intergenic non-protein coding RNA 1234 (LINC01234) participation in cell cycle regulation in adrenocortical carcinoma through bromodomain-containing protein 4 (BRD4) expression mediation via sponging microRNA (miR)-140-3p

description: Many researches indicated that long non-coding RNAs (lncRNAs) were involved in the malignant progression of tumors, including Adrenocortical Carcinoma (ACC). However, as for most lncRNAs, their biological behaviors and molecular mechanism remain unclear in ACC. In the present research, weighted gene co-expression network analysis (WGCNA) was used to identify pathologically relevant gene, including lncRNAs. By comparing their expressions in GSE61359 tumors and normal controls, long intergenic non-protein coding RNA 1234 (LINC01234) was selected to investigate the clinical significance, biological function, and mechanism in ACC. Data mining revealed that LINC01234 expression was significantly up-regulated in ACC patients, and a shorter survival time presents in patients with higher LINC01234 expression compared to that in patients with lower LINC01234 expression. Further, LINC01234 silencing resulted in cells growth arrest in vitro and in vivo. Mechanism studies suggested that LINC01234 silencing induced cell cycle arrest, and bromodomain-containing protein 4 (BRD4) overexpression could restore this phenomenon. Further research showed that LINC01234 could mediate BRD4 expression through competitively sequestering microRNA (miR)-140-3p, as evidenced by the positive correlation of LINC01234 with BRD4 and inverse correlation with miR-140-3p expression. Luciferase activity assay also verified the targeting relationship between LINC01234, BRD4 and miR-140-3p. And up-regulated LINC01234 in ACC cells significantly reversed the degradation of BRD4 by miR-140-3p. Collectively, we deduce that LINC01234 functions as a ceRNA to regulate BRD4 expression by sponging miR-140-3p in ACC progress. Our findings have the potential to provide a new target for the diagnosis and treatment of ACC.
DOI: 10.6084/m9.figshare.20177268
title: Pathological stage-associated non-coding RNA long intergenic non-protein coding RNA 1234 (LINC01234) participation in cell cycle regulation in adrenocortical carcinoma through bromodomain-containing protein 4 (BRD4) expression mediation via sponging microRNA (miR)-140-3p

description: Many researches indicated that long non-coding RNAs (lncRNAs) were involved in the malignant progression of tumors, including Adrenocortical Carcinoma (ACC). However, as for most lncRNAs, their biological behaviors and molecular mechanism remain unclear in ACC. In the present research, weighted gene co-expression network analysis (WGCNA) was used to identify pathologically relevant gene, including lncRNAs. By comparing their expressions in GSE61359 tumors and normal controls, long intergenic non-protein coding RNA 1234 (LINC01234) was selected to investigate the clinical significance, biological function, and mechanism in ACC. Data mining revealed that LINC01234 expression was significantly up-regulated in ACC patients, and a shorter survival time presents in patients with higher LINC01234 expression compared to that in patients with lower LINC01234 expression. Further, LINC01234 silencing resulted in cells growth arrest in vitro and in vivo. Mechanism studies suggested that LINC01234 silencing induced cell cycle arrest, and bromodomain-containing protein 4 (BRD4) overexpression could restore this phenomenon. Further research showed that LINC01234 could mediate BRD4 expression through competitively sequestering microRNA (miR)-140-3p, as evidenced by the positive correlation of LINC01234 with BRD4 and inverse correlation with miR-140-3p expression. Luciferase activity assay also verified the targeting relationship between LINC01234, BRD4 and miR-140-3p. And up-regulated LINC01234 in ACC cells significantly reversed the degradation of BRD4 by miR-140-3p. Collectively, we deduce that LINC01234 functions as a ceRNA to regulate BRD4 expression by sponging miR-140-3p in ACC progress. Our findings have the potential to provide a new target for the diagnosis and treatment of ACC.
DOI: 10.6084/m9.figshare.19128805
title: Additional file 7 of CENPF/CDK1 signaling pathway enhances the progression of adrenocortical carcinoma by regulating the G2/M-phase cell cycle

description: Additional file 7: Table S7. GESA analysis of GO term.
DOI: 10.17632/fwtjvxr32b.1
title: Raw dataset

description: raw dataset and questionnaire
DOI: 10.17632/x62chhf2yc.1
title: Supplemental Table I

description: Additional characteristics of 25 SLE patients taking 39 regimens of OM
DOI: 10.6084/m9.figshare.19128715.v1
title: Additional file 3 of Single-cell analysis of mouse uterus at the invasion phase of embryo implantation

description: Additional file 3: Table S3. The complete list of differentially expressed genes in IS compared to IIS for all cell types (logFC &gt; 0.25 and P &lt; 0.05).
DOI: 10.6084/m9.figshare.19128799.v1
title: Additional file 6 of CENPF/CDK1 signaling pathway enhances the progression of adrenocortical carcinoma by regulating the G2/M-phase cell cycle

description: Additional file 6: Table S6. GSEA enrichment analyses of Biocarta pathway.
DOI: 10.6084/m9.figshare.19128805.v1
title: Additional file 7 of CENPF/CDK1 signaling pathway enhances the progression of adrenocortical carcinoma by regulating the G2/M-phase cell cycle

description: Additional file 7: Table S7. GESA analysis of GO term.
DOI: 10.6084/m9.figshare.19128811
title: Additional file 8 of CENPF/CDK1 signaling pathway enhances the progression of adrenocortical carcinoma by regulating the G2/M-phase cell cycle

description: Additional file 8: Table S8. GSEA enrichment analyses of Hallmark description.
DOI: 10.6084/m9.figshare.19128811.v1
title: Additional file 8 of CENPF/CDK1 signaling pathway enhances the progression of adrenocortical carcinoma by regulating the G2/M-phase cell cycle

description: Additional file 8: Table S8. GSEA enrichment analyses of Hallmark description.
DOI: 10.6084/m9.figshare.19128748
title: Additional file 2 of Prediction of occult tumor progression via platelet RNAs in a mouse melanoma model: a potential new platform for early detection of cancer

description: Additional file 2: Table S9. Differentially expressed mRNAs in platelets of suboptimal inoculation group compared with optimal inoculation group and control group.
DOI: 10.17632/23g756w5k5.1
title: Seasonal trends in atopic dermatitis: A worldwide Google search trends analysis - Supplemental Table 2

description: This is a supplemental file for the paper: Seasonal trends in atopic dermatitis: A worldwide Google search trends analysis. This data includes January 2004 to January 2024 data on search volume index (SVI) of the 42 countries we included in our research paper. It includes SVI for each month corresponding to the term "Atopic eczema" and includes an average at the end of the 42 countries.