cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.3827070.v1
title: Diagnosing colorectal cancer and inflammatory bowel disease in primary care: The usefulness of tests for faecal haemoglobin, faecal calprotectin, anaemia and iron deficiency. A prospective study

description: <b>Objective:</b> Abdominal complaints are common reasons to consult primary care but they are seldom caused by colorectal cancer (CRC), high-risk adenomas (HRAs), or inflammatory bowel disease (IBD). Reliable diagnostic aids would be helpful in deciding which patients to refer for bowel imaging. Our aim was to assess the value of a faecal immunochemical test (FIT) and a faecal calprotectin (FC) test in detecting CRC, HRAs and IBD in primary care, and the value of combining these tests with anaemia and iron-deficiency tests. <b>Materials and methods:</b> This prospective study included 373 consecutive patients that received a FIT or a FC test ordered by a primary care physician. We collected samples for FITs, FC tests, full blood counts and iron-deficiency tests. Physicians were instructed to refer patients with a positive FIT or FC test (cut-off ≥100μg/g) for bowel imaging. The patients’ presenting symptoms were recorded. Patients were followed for 2 years. <b>Results:</b> The best test for detecting CRC and IBD was the combination of the FIT and haemoglobin concentration. This test had a sensitivity, specificity, positive predictive value and negative predictive value of 100%, 61.7%, 11.7% and 100%, respectively. The FIT detected a significantly larger proportion of CRC, HRAs and IBD than the FC test (0.92 versus 0.46, 95% confidence interval 0.22–0.67). <b>Conclusion:</b> A negative FIT combined with a normal haemoglobin concentration could rule out CRC and IBD with a high degree of safety. This could be useful in prioritising referrals for bowel imaging from primary care.
DOI: 10.7910/dvn/v1rjpf/141nm1
title: iqa20150606_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/t9busv
title: iqa20161124_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/j8wzyz
title: iqa20160607_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/8dgxmi
title: iqa20150526_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/eixzpw
title: iqa20150819_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/ooueed
title: iqa20151130_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/h2nixw
title: iqa20160917_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/tjxfnf
title: iqa20160611_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/2tggbk
title: iqa20160728_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/oufq8x
title: iqa20151023_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/qln1ra
title: iqa20161011_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/kiu1jc
title: iqa20150719_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.3827043
title: Head Movement Compensation and Multi-Modal Event Detection

description: Reference implementation accompanying the paper<br>Larsson, L., Schwaller, A. Nyström, M. & Stridh, M. (in press)"Head Movement Compensation and Multi-Modal Event Detection in Eye-Tracking Data for Unconstrained Head Movements". Journal of Neuroscience Methods
DOI: 10.7910/dvn/v1rjpf/9isehp
title: iqa20160808_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.3827043.v2
title: Head Movement Compensation and Multi-Modal Event Detection

description: Reference implementation accompanying the paper<br>Larsson, L., Schwaller, A. Nyström, M. & Stridh, M. (in press)"Head Movement Compensation and Multi-Modal Event Detection in Eye-Tracking Data for Unconstrained Head Movements". Journal of Neuroscience Methods
DOI: 10.6084/m9.figshare.3827043.v1
title: Head Movement Compensation and Multi-Modal Event Detection

description: Reference implementation accompanying the paper<br>Larsson, L., Schwaller, A. Nyström, M. & Stridh, M. (in press)"Head Movement Compensation and Multi-Modal Event Detection in Eye-Tracking Data for Unconstrained Head Movements". Journal of Neuroscience Methods
DOI: 10.7910/dvn/v1rjpf/vx9r3b
title: iqa20150511_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.12912416
title: data_for_datacarpentries

description: intermediate data frame for ggplot lesson
DOI: 10.7910/dvn/v1rjpf/divxue
title: iqa20151105_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/gdvawj
title: iqa20161210_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.3827013
title: NegDDI_MEDLINE.zip

description: NegDDI_Medline Corpus
DOI: 10.7910/dvn/v1rjpf/amhvll
title: iqa20161101_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.3827013.v1
title: NegDDI_MEDLINE.zip

description: NegDDI_Medline Corpus
DOI: 10.7910/dvn/v1rjpf/bcqulv
title: iqa20161029_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.3827010
title: NegDDI_DrugBank.zip

description: NegDDI_DrugBank Corpus
DOI: 10.7910/dvn/v1rjpf/uydd6o
title: iqa20160524_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/1hng04
title: iqa20151019_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/kjmuhg
title: iqa20150405_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/roidhv
title: iqa20150814_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/tdrnr3
title: iqa20151007_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.3826998
title: What species of horse was coeval with North America's earliest humans in the Paisley Caves?

description: SUPPLEMENTAL DATA—Supplemental materials are available for this article for free at www.tandfonline.com/UJVP Citation for this article: McHorse, B. K., E. Byrd Davis, E. Scott, and D. L. Jenkins. 2016. What species of horse was coeval with North America's earliest humans in the Paisley Caves? Journal of Vertebrate Paleontology. DOI: 10.1080/02724634.2016.1214595.
DOI: 10.7910/dvn/v1rjpf/4yuv9u
title: iqa20150122_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.3826998.v2
title: What species of horse was coeval with North America's earliest humans in the Paisley Caves?

description: SUPPLEMENTAL DATA—Supplemental materials are available for this article for free at www.tandfonline.com/UJVP Citation for this article: McHorse, B. K., E. Byrd Davis, E. Scott, and D. L. Jenkins. 2016. What species of horse was coeval with North America's earliest humans in the Paisley Caves? Journal of Vertebrate Paleontology. DOI: 10.1080/02724634.2016.1214595.
DOI: 10.7910/dvn/v1rjpf/b2ti0l
title: iqa20150214_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.3826998.v1
title: What species of horse was coeval with North America's earliest humans in the Paisley Caves?

description: SUPPLEMENTAL DATA—Supplemental materials are available for this article for free at www.tandfonline.com/UJVP Citation for this article: McHorse, B. K., E. Byrd Davis, E. Scott, and D. L. Jenkins. 2016. What species of horse was coeval with North America's earliest humans in the Paisley Caves? Journal of Vertebrate Paleontology. DOI: 10.1080/02724634.2016.1214595.
DOI: 10.7910/dvn/v1rjpf/qsfd19
title: iqa20150424_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/mhczrp
title: iqa20160111_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/rv9xzm
title: iqa20150221_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/knho6g
title: iqa20151129_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/x0ncse
title: iqa20150730_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/68r3bo
title: iqa20161122_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/recw1z
title: iqa20151018_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/rwv7of
title: iqa20150828_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.3826971
title: Autophagy regulates cytoplasmic remodeling during cell reprogramming in a zebrafish model of muscle regeneration

description: Cell identity involves both selective gene activity and specialization of cytoplasmic architecture and protein machinery. Similarly, reprogramming differentiated cells requires both genetic program alterations and remodeling of the cellular architecture. While changes in genetic and epigenetic programs have been well documented in dedifferentiating cells, the pathways responsible for remodeling the cellular architecture and eliminating specialized protein complexes are not as well understood. Here, we utilize a zebrafish model of adult muscle regeneration to study cytoplasmic remodeling during cell dedifferentiation. We describe activation of autophagy early in the regenerative response to muscle injury, while blocking autophagy using chloroquine or Atg5 and Becn1 knockdown reduced the rate of regeneration with accumulation of sarcomeric and nuclear debris. We further identify Casp3/caspase 3 as a candidate mediator of cellular reprogramming and Fgf signaling as an important activator of autophagy in dedifferentiating myocytes. We conclude that autophagy plays a critical role in cell reprogramming by regulating cytoplasmic remodeling, facilitating the transition to a less differentiated cell identity.
DOI: 10.7910/dvn/v1rjpf/z7850b
title: iqa20150308_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/ol70kc
title: iqa20150509_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.3826971.v2
title: Autophagy regulates cytoplasmic remodeling during cell reprogramming in a zebrafish model of muscle regeneration

description: Cell identity involves both selective gene activity and specialization of cytoplasmic architecture and protein machinery. Similarly, reprogramming differentiated cells requires both genetic program alterations and remodeling of the cellular architecture. While changes in genetic and epigenetic programs have been well documented in dedifferentiating cells, the pathways responsible for remodeling the cellular architecture and eliminating specialized protein complexes are not as well understood. Here, we utilize a zebrafish model of adult muscle regeneration to study cytoplasmic remodeling during cell dedifferentiation. We describe activation of autophagy early in the regenerative response to muscle injury, while blocking autophagy using chloroquine or Atg5 and Becn1 knockdown reduced the rate of regeneration with accumulation of sarcomeric and nuclear debris. We further identify Casp3/caspase 3 as a candidate mediator of cellular reprogramming and Fgf signaling as an important activator of autophagy in dedifferentiating myocytes. We conclude that autophagy plays a critical role in cell reprogramming by regulating cytoplasmic remodeling, facilitating the transition to a less differentiated cell identity.
DOI: 10.6084/m9.figshare.3826971.v1
title: Autophagy regulates cytoplasmic remodeling during cell reprogramming in a zebrafish model of muscle regeneration

description: Cell identity involves both selective gene activity and specialization of cytoplasmic architecture and protein machinery. Similarly, reprogramming differentiated cells requires both genetic program alterations and remodeling of the cellular architecture. While changes in genetic and epigenetic programs have been well documented in dedifferentiating cells, the pathways responsible for remodeling the cellular architecture and eliminating specialized protein complexes are not as well understood. Here, we utilize a zebrafish model of adult muscle regeneration to study cytoplasmic remodeling during cell dedifferentiation. We describe activation of autophagy early in the regenerative response to muscle injury, while blocking autophagy using chloroquine or Atg5 and Becn1 knockdown reduced the rate of regeneration with accumulation of sarcomeric and nuclear debris. We further identify Casp3/caspase 3 as a candidate mediator of cellular reprogramming and Fgf signaling as an important activator of autophagy in dedifferentiating myocytes. We conclude that autophagy plays a critical role in cell reprogramming by regulating cytoplasmic remodeling, facilitating the transition to a less differentiated cell identity.
DOI: 10.7910/dvn/v1rjpf/rculzt
title: iqa20160530_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/i2qamq
title: iqa20161030_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.3826965
title: Identification of Differentially Expressed Genes and Pathways for Myofiber Characteristics in Soleus Muscles between Chicken Breeds Differing in Meat Quality

description: In the modern chicken industry, fast-growing broilers have undergone strong artificial selection for muscle growth, which has led to remarkable phenotypic variations compared with slow-growing chickens. However, the molecular mechanism underlying these phenotypes differences remains unknown. In this study, a systematic identification of candidate genes and new pathways related to myofiber development and composition in chicken Soleus muscle (SOL) has been made using gene expression profiles of two distinct breeds: Qingyuan partridge (QY), a slow-growing Chinese breed possessing high meat quality and Cobb 500 (CB), a commercial fast-growing broiler line. Agilent cDNA microarray analyses were conducted to determine gene expression profiles of soleus muscle sampled at sexual maturity age of QY (112 d) and CB (42 d). The 1318 genes with at least 2-fold differences were identified (P
DOI: 10.7910/dvn/v1rjpf/wrxzq0
title: iqa20150915_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.3826965.v1
title: Identification of Differentially Expressed Genes and Pathways for Myofiber Characteristics in Soleus Muscles between Chicken Breeds Differing in Meat Quality

description: In the modern chicken industry, fast-growing broilers have undergone strong artificial selection for muscle growth, which has led to remarkable phenotypic variations compared with slow-growing chickens. However, the molecular mechanism underlying these phenotypes differences remains unknown. In this study, a systematic identification of candidate genes and new pathways related to myofiber development and composition in chicken Soleus muscle (SOL) has been made using gene expression profiles of two distinct breeds: Qingyuan partridge (QY), a slow-growing Chinese breed possessing high meat quality and Cobb 500 (CB), a commercial fast-growing broiler line. Agilent cDNA microarray analyses were conducted to determine gene expression profiles of soleus muscle sampled at sexual maturity age of QY (112 d) and CB (42 d). The 1318 genes with at least 2-fold differences were identified (P
DOI: 10.7910/dvn/v1rjpf/vlhxgj
title: iqa20160606_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.3826770
title: Brief Study on the correlation between Hair and Eye Colour

description: <b>Study</b> In BIOL 2050 Lab 7, a survey was conducted amongst the students that was able to determine the difference between their eye colour and hair colour.<b>Methods</b> Throughout this brief survey, 15 people were anonymously asked in the laboratory what their eye colour and hair colour were and recorded. <b>Hypothesis</b> There is a correlation between students that have brown eyes and black hair traits.<b>Prediction</b> It is predicted that students who have brown eyes will have black hair due to frequency of people having this dominant trait at York University.
DOI: 10.7910/dvn/v1rjpf/tufdou
title: iqa20150502_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.3826770.v1
title: Brief Study on the correlation between Hair and Eye Colour

description: <b>Study</b> In BIOL 2050 Lab 7, a survey was conducted amongst the students that was able to determine the difference between their eye colour and hair colour.<b>Methods</b> Throughout this brief survey, 15 people were anonymously asked in the laboratory what their eye colour and hair colour were and recorded. <b>Hypothesis</b> There is a correlation between students that have brown eyes and black hair traits.<b>Prediction</b> It is predicted that students who have brown eyes will have black hair due to frequency of people having this dominant trait at York University.
DOI: 10.7910/dvn/v1rjpf/mv4udt
title: iqa20150505_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/m9clu1
title: iqa20160908_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.3826755
title: Correlation Between Laptop Users and Students With Glasses Or Contact Lenses

description: <strong>Study: </strong>This study was executed to determine if there was a correlation between students who use laptops in class and students who wear glasses or contact lenses.<br><b>Methodology:</b>A verbal survey was conducted on classmates to see if they currently have a laptop with them and if they are currently wearing glasses or contact lenses.<br><strong>Techniques Used:</strong>To avoid confusion and surveying the same person twice, one group member carried out the survey while the other group members discussed other parts of the laboratory.<br><b>Hypothesis:</b>There is a correlation between students who use laptops and students who wear glasses or contact lenses.<b><br></b><b>Prediction:</b>Students who own laptops tend to damage their eyes more from looking at the computer screen, thus needing glasses or contacts.<br>
DOI: 10.7910/dvn/v1rjpf/xmssvh
title: iqa20150108_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.3826755.v1
title: Correlation Between Laptop Users and Students With Glasses Or Contact Lenses

description: <strong>Study: </strong>This study was executed to determine if there was a correlation between students who use laptops in class and students who wear glasses or contact lenses.<br><b>Methodology:</b>A verbal survey was conducted on classmates to see if they currently have a laptop with them and if they are currently wearing glasses or contact lenses.<br><strong>Techniques Used:</strong>To avoid confusion and surveying the same person twice, one group member carried out the survey while the other group members discussed other parts of the laboratory.<br><b>Hypothesis:</b>There is a correlation between students who use laptops and students who wear glasses or contact lenses.<b><br></b><b>Prediction:</b>Students who own laptops tend to damage their eyes more from looking at the computer screen, thus needing glasses or contacts.<br>
DOI: 10.7910/dvn/v1rjpf/bgsy1n
title: iqa20160601_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/a3srav
title: iqa20150614_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/7oiand
title: iqa20151126_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.3826743
title: A comparison of an individual's eye colour to their use of glasses

description: <b>Hypothesis:</b> The darker an individual’s eye colour is, the more likely it is for that individual to wear glasses, resulting in a positive correlation. <b>Prediction: </b> I predict that with darker eye colours comes the higher likelihood of needing glasses, because darker colours are known to absorb more U.V. light coming from the sun, therefore the individuals with darker eyes are more prone eye damage. The damage done to the eyes would then be corrected with glasses. <b>Description of studies:</b> In this study, an individual’s eye colour was sampled for the first variable (with no specific options given), and for the second variable, the individual was asked about whether he/she is wearing glasses, and this was conducted in the form of a yes or no question. <b>Methods: </b> For this study, our group sampled the individuals within the lab room, by walking around and asking everyone the necessary question that were mentioned in the description of the study. <b>Meta Data:</b> Our data was divided into two columns representing each of our two variables that were explored in the study. One for the question regarding eye colour and the other for the question regarding the use of glasses. The data for eye colour is qualitative meaning the answer is a description not a numerical value. While the data collected for glasses use is categorical, meaning there was two options to choose from (yes or no). The eye colour data is represented by various colour and no specific option was given, also the descriptive characteristics were allowed (dark brown, light brown). As for the data for glasses use, the answers were based on whether they wear glasses on that day or any other day and at home.
DOI: 10.7910/dvn/v1rjpf/7qcqmk
title: iqa20160930_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.3826743.v1
title: A comparison of an individual's eye colour to their use of glasses

description: <b>Hypothesis:</b> The darker an individual’s eye colour is, the more likely it is for that individual to wear glasses, resulting in a positive correlation. <b>Prediction: </b> I predict that with darker eye colours comes the higher likelihood of needing glasses, because darker colours are known to absorb more U.V. light coming from the sun, therefore the individuals with darker eyes are more prone eye damage. The damage done to the eyes would then be corrected with glasses. <b>Description of studies:</b> In this study, an individual’s eye colour was sampled for the first variable (with no specific options given), and for the second variable, the individual was asked about whether he/she is wearing glasses, and this was conducted in the form of a yes or no question. <b>Methods: </b> For this study, our group sampled the individuals within the lab room, by walking around and asking everyone the necessary question that were mentioned in the description of the study. <b>Meta Data:</b> Our data was divided into two columns representing each of our two variables that were explored in the study. One for the question regarding eye colour and the other for the question regarding the use of glasses. The data for eye colour is qualitative meaning the answer is a description not a numerical value. While the data collected for glasses use is categorical, meaning there was two options to choose from (yes or no). The eye colour data is represented by various colour and no specific option was given, also the descriptive characteristics were allowed (dark brown, light brown). As for the data for glasses use, the answers were based on whether they wear glasses on that day or any other day and at home.
DOI: 10.7910/dvn/v1rjpf/xfjdie
title: iqa20160509_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/3purfz
title: iqa20150813_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/pgafxy
title: iqa20161023_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/ovnlth
title: iqa20150426_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/utsgt9
title: iqa20161025_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/vimrxb
title: iqa20150525_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/ere1gh
title: iqa20150929_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/khu3fi
title: iqa20151123_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/rfno5r
title: iqa20150916_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.3826725
title: Mitotic cells form actin-based bridges with adjacent cells to provide intercellular communication during rounding

description: In order to achieve accurate chromosome segregation, eukaryotic cells undergo a dramatic change in morphology to obtain a spherical shape during mitosis. Interphase cells communicate directly with each other by exchanging ions and small molecules via gap junctions, which have important roles in controlling cell growth and differentiation. As cells round up during mitosis, the gap junctional communication between mitotic cells and adjacent interphase cells ceases. Whether mitotic cells use alternative mechanisms for mediating direct cell-cell communication during rounding is currently unknown. Here, we have studied the mechanisms involved in the remodeling of gap junctions during mitosis. We further demonstrate that mitotic cells are able to form actin-based plasma membrane bridges with adjacent cells during rounding. These structures, termed “mitotic nanotubes,” were found to be involved in mediating the transport of cytoplasm, including Rab11-positive vesicles, between mitotic cells and adjacent cells. Moreover, a subpool of the gap-junction channel protein connexin43 localized in these intercellular bridges during mitosis. Collectively, the data provide new insights into the mechanisms involved in the remodeling of gap junctions during mitosis and identify actin-based plasma membrane bridges as a novel means of communication between mitotic cells and adjacent cells during rounding.