cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.3759267
title: A miniature notosuchian with multicuspid teeth from the Cretaceous of Morocco

description: Notosuchians from Cretaceous continental environments of Gondwana have developed an unexpected array of morphologies comparable to mammals and their extinct relatives. However, this exceptional diversity is unbalanced, with South America holding nearly three times the generic diversity of Africa-Madagascar. With the exception of the triconodonts and of a very specialized group, the Gondwanatheria, in none of these landmasses do mammals dominate, and as a result, the low notosuchian diversity in Africa-Madagascar appears to be an artifact of sampling. Here, we describe a new miniature notosuchian from the Albian-Cenomanian Kem-Kem Beds of Morocco filling this gap. <i>Lavocatchampsa sigogneaurussellae</i>, gen. et sp. nov., exhibits a new type of heterodonty with absence of maxillary and dentary caniniform dentitions and teeth that gradually become massive posteriorly, and possess a sharp elongate median carina flanked by two multicusped cingula. The occlusion pattern is revealed by computed tomography and scanning electron microscopy (SEM) and shows that the main component of jaw closure is vertical, and not horizontal as has been proposed in closely related forms. Phylogenetic analysis recovers the new taxon as part of a basal stock of Gondwanan ziphosuchians with close affinities to <i>Candidodon itapecuruense, Malawisuchus mwakasyungutiensis</i>, and <i>Pakasuchus kapilimai</i>. We revise the diagnosis of Candidodontidae, a clade characterized by a particular heterodont dentition recalling that of triconodont mammals. The recognition of this new clade confirms previous hypotheses of a vicariant vertebrate assemblage present on a continuous South American–African landmass. http://zoobank.org/urn:lsid:zoobank.org:pub:0D35356B-67FF-49A2-A518-6C19961A0894 SUPPLEMENTAL DATA—Supplemental materials are available for this article for free at www.tandfonline.com/ujvp Citation for this article: Martin, J. E., and F. de Lapparent de Broin. 2016. A miniature notosuchian with multicuspid teeth from the Cretaceous of Morocco. Journal of Vertebrate Paleontology. DOI: 10.1080/02724634.2016.1211534.
DOI: 10.6084/m9.figshare.3759267.v1
title: A miniature notosuchian with multicuspid teeth from the Cretaceous of Morocco

description: Notosuchians from Cretaceous continental environments of Gondwana have developed an unexpected array of morphologies comparable to mammals and their extinct relatives. However, this exceptional diversity is unbalanced, with South America holding nearly three times the generic diversity of Africa-Madagascar. With the exception of the triconodonts and of a very specialized group, the Gondwanatheria, in none of these landmasses do mammals dominate, and as a result, the low notosuchian diversity in Africa-Madagascar appears to be an artifact of sampling. Here, we describe a new miniature notosuchian from the Albian-Cenomanian Kem-Kem Beds of Morocco filling this gap. <i>Lavocatchampsa sigogneaurussellae</i>, gen. et sp. nov., exhibits a new type of heterodonty with absence of maxillary and dentary caniniform dentitions and teeth that gradually become massive posteriorly, and possess a sharp elongate median carina flanked by two multicusped cingula. The occlusion pattern is revealed by computed tomography and scanning electron microscopy (SEM) and shows that the main component of jaw closure is vertical, and not horizontal as has been proposed in closely related forms. Phylogenetic analysis recovers the new taxon as part of a basal stock of Gondwanan ziphosuchians with close affinities to <i>Candidodon itapecuruense, Malawisuchus mwakasyungutiensis</i>, and <i>Pakasuchus kapilimai</i>. We revise the diagnosis of Candidodontidae, a clade characterized by a particular heterodont dentition recalling that of triconodont mammals. The recognition of this new clade confirms previous hypotheses of a vicariant vertebrate assemblage present on a continuous South American–African landmass. http://zoobank.org/urn:lsid:zoobank.org:pub:0D35356B-67FF-49A2-A518-6C19961A0894 SUPPLEMENTAL DATA—Supplemental materials are available for this article for free at www.tandfonline.com/ujvp Citation for this article: Martin, J. E., and F. de Lapparent de Broin. 2016. A miniature notosuchian with multicuspid teeth from the Cretaceous of Morocco. Journal of Vertebrate Paleontology. DOI: 10.1080/02724634.2016.1211534.
DOI: 10.6084/m9.figshare.3759255
title: A <i>Dorcatherium</i> (Mammalia, Ruminantia, Middle Miocene) petrosal bone and the tragulid ear region

description: A petrosal bone from the French Middle Miocene locality Sansan is described. It belongs to the tragulid species <i>Dorcatherium crassum</i>. Using high-resolution X-ray computed tomography, we scanned this petrosal bone and segmented its embedded bony labyrinth. We compared the morphological data with those of three living Tragulidae: <i>Tragulus javanicus, Hyemoschus aquaticus</i>, and <i>Moschiola meminna</i>. We ran a phylogenetic analysis where fossil and extant pecoran ruminants were included to understand the distribution of characters of the petrosal bone and bony labyrinth within ruminants. We propose a set of new synapomorphies for the Tragulidae among the Ruminantia, including the absence of the basicapsular groove, a knob-shaped mastoid region, a knob anterior to the subarcuate fossa on the petrosal bone, a high number of cochlea turns, the dorsal insertion of the posterior limb of the lateral semicircular canal, the extension of the lateral semicircular canal beyond the plane of the posterior semicircular canal in dorsal view, and a pouch-like endolymphatic sac on the bony labyrinth. The clade constituted by <i>Tragulus</i> and <i>Moschiola</i> is confirmed by new synapomorphies such as a double convexity of the promontorium and a large pouch-like endolymphatic sac that covers the common crus. We demonstrate the potential of characters of the bony labyrinth for the phylogeny of ruminants. SUPPLEMENTAL DATA—Supplemental materials are available for this article for free at www.tandfonline.com/UJVP Citation for this article: Mennecart, B., and L. Costeur. 2016. A <i>Dorcatherium</i> (Mammalia, Ruminantia, Middle Miocene) petrosal bone and the tragulid ear region. Journal of Vertebrate Paleontology. DOI: 10.1080/02724634.2016.1211665.
DOI: 10.6084/m9.figshare.3759255.v1
title: A <i>Dorcatherium</i> (Mammalia, Ruminantia, Middle Miocene) petrosal bone and the tragulid ear region

description: A petrosal bone from the French Middle Miocene locality Sansan is described. It belongs to the tragulid species <i>Dorcatherium crassum</i>. Using high-resolution X-ray computed tomography, we scanned this petrosal bone and segmented its embedded bony labyrinth. We compared the morphological data with those of three living Tragulidae: <i>Tragulus javanicus, Hyemoschus aquaticus</i>, and <i>Moschiola meminna</i>. We ran a phylogenetic analysis where fossil and extant pecoran ruminants were included to understand the distribution of characters of the petrosal bone and bony labyrinth within ruminants. We propose a set of new synapomorphies for the Tragulidae among the Ruminantia, including the absence of the basicapsular groove, a knob-shaped mastoid region, a knob anterior to the subarcuate fossa on the petrosal bone, a high number of cochlea turns, the dorsal insertion of the posterior limb of the lateral semicircular canal, the extension of the lateral semicircular canal beyond the plane of the posterior semicircular canal in dorsal view, and a pouch-like endolymphatic sac on the bony labyrinth. The clade constituted by <i>Tragulus</i> and <i>Moschiola</i> is confirmed by new synapomorphies such as a double convexity of the promontorium and a large pouch-like endolymphatic sac that covers the common crus. We demonstrate the potential of characters of the bony labyrinth for the phylogeny of ruminants. SUPPLEMENTAL DATA—Supplemental materials are available for this article for free at www.tandfonline.com/UJVP Citation for this article: Mennecart, B., and L. Costeur. 2016. A <i>Dorcatherium</i> (Mammalia, Ruminantia, Middle Miocene) petrosal bone and the tragulid ear region. Journal of Vertebrate Paleontology. DOI: 10.1080/02724634.2016.1211665.
DOI: 10.6084/m9.figshare.3759246
title: <i>Palaeobatrachus eurydices</i>, sp. nov. (Amphibia, Anura), the last Western European palaeobatrachid

description: Disarticulated remains of palaeobatrachids coming from the early Pleistocene (Gelasian) of Tegelen (The Netherlands) are here described and referred to the new species <i>Palaeobatrachus eurydices</i>. The new species has been included in the first comprehensive phylogenetic analysis considering all known species of the genus <i>Palaeobatrachus</i> and was found to be the sister taxon of the Oligocene/Miocene <i>P. robustus. Palaeobatrachus eurydices</i> + <i>P. robustus</i> form a clade with <i>P. langhae</i>, and this latter clade is sister to all other <i>Palaeobatrachus</i> species. Extreme adaptation to permanent life in water is evidenced in <i>P. eurydices</i> by absence of the fossa cubitalis ventralis, and less developed olecranon on the radioulna. The water-rich and warm environment of Tegelen, indicated by other elements of the fauna such as beavers and the terrapin <i>Mauremys</i>, could have acted as a refugium for these water-dwelling anurans, which were thought to have disappeared from western Europe by the Miocene/Pliocene boundary. http://zoobank.org/urn:lsid:zoobank.org:pub:377FD70A-C201-4F95-BB30-BF5CE0D75A3F SUPPLEMENTAL DATA—Supplemental materials are available for this article for free at www.tandfonline.com/UJVP Citation for this article: Villa, A., Z. Roček, E. Tschopp, L. W. van den Hoek Ostende, and M. Delfino. 2016. <i>Palaeobatrachus eurydices</i>, sp. nov. (Amphibia, Anura), the last western European palaeobatrachid. Journal of Vertebrate Paleontology. DOI: 10.1080/02724634.2016.1211664.
DOI: 10.17632/g4mm5yvx2d.1
title: LINF_010005600

description: BSD- domain containing protein
DOI: 10.6084/m9.figshare.3759246.v2
title: <i>Palaeobatrachus eurydices</i>, sp. nov. (Amphibia, Anura), the last Western European palaeobatrachid

description: Disarticulated remains of palaeobatrachids coming from the early Pleistocene (Gelasian) of Tegelen (The Netherlands) are here described and referred to the new species <i>Palaeobatrachus eurydices</i>. The new species has been included in the first comprehensive phylogenetic analysis considering all known species of the genus <i>Palaeobatrachus</i> and was found to be the sister taxon of the Oligocene/Miocene <i>P. robustus. Palaeobatrachus eurydices</i> + <i>P. robustus</i> form a clade with <i>P. langhae</i>, and this latter clade is sister to all other <i>Palaeobatrachus</i> species. Extreme adaptation to permanent life in water is evidenced in <i>P. eurydices</i> by absence of the fossa cubitalis ventralis, and less developed olecranon on the radioulna. The water-rich and warm environment of Tegelen, indicated by other elements of the fauna such as beavers and the terrapin <i>Mauremys</i>, could have acted as a refugium for these water-dwelling anurans, which were thought to have disappeared from western Europe by the Miocene/Pliocene boundary. http://zoobank.org/urn:lsid:zoobank.org:pub:377FD70A-C201-4F95-BB30-BF5CE0D75A3F SUPPLEMENTAL DATA—Supplemental materials are available for this article for free at www.tandfonline.com/UJVP Citation for this article: Villa, A., Z. Roček, E. Tschopp, L. W. van den Hoek Ostende, and M. Delfino. 2016. <i>Palaeobatrachus eurydices</i>, sp. nov. (Amphibia, Anura), the last western European palaeobatrachid. Journal of Vertebrate Paleontology. DOI: 10.1080/02724634.2016.1211664.
DOI: 10.6084/m9.figshare.3759246.v1
title: <i>Palaeobatrachus eurydices</i>, sp. nov. (Amphibia, Anura), the last western European palaeobatrachid

description: Disarticulated remains of palaeobatrachids coming from the early Pleistocene (Gelasian) of Tegelen (The Netherlands) are here described and referred to the new species <i>Palaeobatrachus eurydices</i>. The new species has been included in the first comprehensive phylogenetic analysis considering all known species of the genus <i>Palaeobatrachus</i> and was found to be the sister taxon of the Oligocene/Miocene <i>P. robustus. Palaeobatrachus eurydices</i> + <i>P. robustus</i> form a clade with <i>P. langhae</i>, and this latter clade is sister to all other <i>Palaeobatrachus</i> species. Extreme adaptation to permanent life in water is evidenced in <i>P. eurydices</i> by absence of the fossa cubitalis ventralis, and less developed olecranon on the radioulna. The water-rich and warm environment of Tegelen, indicated by other elements of the fauna such as beavers and the terrapin <i>Mauremys</i>, could have acted as a refugium for these water-dwelling anurans, which were thought to have disappeared from western Europe by the Miocene/Pliocene boundary. http://zoobank.org/urn:lsid:zoobank.org:pub:377FD70A-C201-4F95-BB30-BF5CE0D75A3F SUPPLEMENTAL DATA—Supplemental materials are available for this article for free at www.tandfonline.com/UJVP Citation for this article: Villa, A., Z. Roček, E. Tschopp, L. W. van den Hoek Ostende, and M. Delfino. 2016. <i>Palaeobatrachus eurydices</i>, sp. nov. (Amphibia, Anura), the last western European palaeobatrachid. Journal of Vertebrate Paleontology. DOI: 10.1080/02724634.2016.1211664.
DOI: 10.6084/m9.figshare.3759240
title: Critical current characterisation of Nexans Bi-2212 superconducting wire

description: Detailed measurements of the critical current of a Bi-2212 wire as a function of temperature, magnetic field, and field angle, performed at the Robinson Research Institute of Victoria University of Wellington.<br>This wire is described in C.-E. Bruzek, N. Lallouet, E. Flahaut, D. Bourgault, J.-M. Saugrain, A. Allais, S. Arsac, J. Bock, J. Ehrenberg, D. E. Wesolowski and M. O. Rikel, <i>High-performance Bi2212/Ag tape produced at NEXANS</i>, Proceedings of the European Conference on Applied Superconductivity 2003, IOP Conf. Ser. 181 (2004) 2260.
DOI: 10.6084/m9.figshare.3759198
title: Expression dynamics, relationships, and transcriptional regulations of diverse transcripts in mouse spermatogenic cells

description: Among all tissues of the metazoa, the transcritpome of testis displays the highest diversity and specificity. However, its composition and dynamics during spermatogenesis have not been fully understood. Here, we have identified 20,639 message RNAs (mRNAs), 7,168 long non-coding RNAs (lncRNAs) and 15,101 circular RNAs (circRNAs) in mouse spermatogenic cells, and found many of them were specifically expressed in testes. lncRNAs are significantly more testis-specific than mRNAs. At all stages, mRNAs are generally more abundant than lncRNAs, and linear transcripts are more abundant than circRNAs. We showed that the productions of circRNAs and piRNAs were highly regulated instead of random processes. Based on the results of a small-scale functional screening experiment using cultured mouse spermatogonial stem cells, many evolutionarily conserved lncRNAs are likely to play roles in spermatogenesis. Typical classes of transcription factor binding sites are enriched in the promoters of testis-specific m/lncRNA genes. Target genes of CREM and RFX2, 2 key TFs for spermatogenesis, were further validated by using ChIP-chip assays and RNA-seq on RFX2-knockout spermatogenic cells. Our results contribute to the current understanding of the transcriptomic complexity of spermatogenic cells and provide a valuable resource from which many candidate genes may be selected for further functional studies.
DOI: 10.6084/m9.figshare.3759198.v2
title: Expression dynamics, relationships, and transcriptional regulations of diverse transcripts in mouse spermatogenic cells

description: Among all tissues of the metazoa, the transcritpome of testis displays the highest diversity and specificity. However, its composition and dynamics during spermatogenesis have not been fully understood. Here, we have identified 20,639 message RNAs (mRNAs), 7,168 long non-coding RNAs (lncRNAs) and 15,101 circular RNAs (circRNAs) in mouse spermatogenic cells, and found many of them were specifically expressed in testes. lncRNAs are significantly more testis-specific than mRNAs. At all stages, mRNAs are generally more abundant than lncRNAs, and linear transcripts are more abundant than circRNAs. We showed that the productions of circRNAs and piRNAs were highly regulated instead of random processes. Based on the results of a small-scale functional screening experiment using cultured mouse spermatogonial stem cells, many evolutionarily conserved lncRNAs are likely to play roles in spermatogenesis. Typical classes of transcription factor binding sites are enriched in the promoters of testis-specific m/lncRNA genes. Target genes of CREM and RFX2, 2 key TFs for spermatogenesis, were further validated by using ChIP-chip assays and RNA-seq on RFX2-knockout spermatogenic cells. Our results contribute to the current understanding of the transcriptomic complexity of spermatogenic cells and provide a valuable resource from which many candidate genes may be selected for further functional studies.
DOI: 10.6084/m9.figshare.3759198.v1
title: Expression dynamics, relationships, and transcriptional regulations of diverse transcripts in mouse spermatogenic cells

description: Among all tissues of the metazoa, the transcritpome of testis displays the highest diversity and specificity. However, its composition and dynamics during spermatogenesis have not been fully understood. Here, we have identified 20,639 message RNAs (mRNAs), 7,168 long non-coding RNAs (lncRNAs) and 15,101 circular RNAs (circRNAs) in mouse spermatogenic cells, and found many of them were specifically expressed in testes. lncRNAs are significantly more testis-specific than mRNAs. At all stages, mRNAs are generally more abundant than lncRNAs, and linear transcripts are more abundant than circRNAs. We showed that the productions of circRNAs and piRNAs were highly regulated instead of random processes. Based on the results of a small-scale functional screening experiment using cultured mouse spermatogonial stem cells, many evolutionarily conserved lncRNAs are likely to play roles in spermatogenesis. Typical classes of transcription factor binding sites are enriched in the promoters of testis-specific m/lncRNA genes. Target genes of CREM and RFX2, 2 key TFs for spermatogenesis, were further validated by using ChIP-chip assays and RNA-seq on RFX2-knockout spermatogenic cells. Our results contribute to the current understanding of the transcriptomic complexity of spermatogenic cells and provide a valuable resource from which many candidate genes may be selected for further functional studies.
DOI: 10.6084/m9.figshare.3759195
title: DNA damage responsive miR-33b-3p promoted lung cancer cells survival and cisplatin resistance by targeting p21<sup>WAF1/CIP1</sup>

description: Cisplatin is the most potent and widespread used chemotherapy drug for lung cancer treatment. However, the development of resistance to cisplatin is a major obstacle in clinical therapy. The principal mechanism of cisplatin is the induction of DNA damage, thus the capability of DNA damage response (DDR) is a key factor that influences the cisplatin sensitivity of cancer cells. Recent advances have demonstrated that miRNAs (microRNAs) exerted critical roles in DNA damage response; nonetheless, the association between DNA damage responsive miRNAs and cisplatin resistance and its underlying molecular mechanism still require further investigation. The present study has attempted to identify differentially expressed miRNAs in cisplatin induced DNA damage response in lung cancer cells, and probe into the effects of the misexpressed miRNAs on cisplatin sensitivity. Deep sequencing showed that miR-33b-3p was dramatically down-regulated in cisplatin-induced DNA damage response in A549 cells; and ectopic expression of miR-33b-3p endowed the lung cancer cells with enhanced survival and decreased γH2A.X expression level under cisplatin treatment. Consistently, silencing of miR-33b-3p in the cisplatin-resistant A549/DDP cells evidently sensitized the cells to cisplatin. Furthermore, we identified CDKN1A (p21) as a functional target of miR-33b-3p, a critical regulator of G1/S checkpoint, which potentially mediated the protection effects of miR-33b-3p against cisplatin. In aggregate, our results suggested that miR-33b-3p modulated the cisplatin sensitivity of cancer cells might probably through impairing the DNA damage response. And the knowledge of the drug resistance conferred by miR-33b-3p has great clinical implications for improving the efficacy of chemotherapies for treating lung cancers.
DOI: 10.6084/m9.figshare.3759195.v1
title: DNA damage responsive miR-33b-3p promoted lung cancer cells survival and cisplatin resistance by targeting p21<sup>WAF1/CIP1</sup>

description: Cisplatin is the most potent and widespread used chemotherapy drug for lung cancer treatment. However, the development of resistance to cisplatin is a major obstacle in clinical therapy. The principal mechanism of cisplatin is the induction of DNA damage, thus the capability of DNA damage response (DDR) is a key factor that influences the cisplatin sensitivity of cancer cells. Recent advances have demonstrated that miRNAs (microRNAs) exerted critical roles in DNA damage response; nonetheless, the association between DNA damage responsive miRNAs and cisplatin resistance and its underlying molecular mechanism still require further investigation. The present study has attempted to identify differentially expressed miRNAs in cisplatin induced DNA damage response in lung cancer cells, and probe into the effects of the misexpressed miRNAs on cisplatin sensitivity. Deep sequencing showed that miR-33b-3p was dramatically down-regulated in cisplatin-induced DNA damage response in A549 cells; and ectopic expression of miR-33b-3p endowed the lung cancer cells with enhanced survival and decreased γH2A.X expression level under cisplatin treatment. Consistently, silencing of miR-33b-3p in the cisplatin-resistant A549/DDP cells evidently sensitized the cells to cisplatin. Furthermore, we identified CDKN1A (p21) as a functional target of miR-33b-3p, a critical regulator of G1/S checkpoint, which potentially mediated the protection effects of miR-33b-3p against cisplatin. In aggregate, our results suggested that miR-33b-3p modulated the cisplatin sensitivity of cancer cells might probably through impairing the DNA damage response. And the knowledge of the drug resistance conferred by miR-33b-3p has great clinical implications for improving the efficacy of chemotherapies for treating lung cancers.