cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.10075235.v4
title: Supplementary Material for: Design and Baseline Characteristics of the Finerenone in Reducing Cardiovascular Mortality and Morbidity in Diabetic Kidney Disease Trial

description: <b><i>Background:</i></b> Among people with diabetes, those with kidney disease have exceptionally high rates of cardiovascular (CV) morbidity and mortality and progression of their underlying kidney disease. Finerenone is a novel, nonsteroidal, selective mineralocorticoid receptor antagonist that has shown to reduce albuminuria in type 2 diabetes (T2D) patients with chronic kidney disease (CKD) while revealing only a low risk of hyperkalemia. However, the effect of finerenone on CV and renal outcomes has not yet been investigated in long-term trials. <b><i>Patients and</i></b> <b><i>Methods:</i></b> The Finerenone in Reducing CV Mortality and Morbidity in Diabetic Kidney Disease (FIGARO-DKD) trial aims to assess the efficacy and safety of finerenone compared to placebo at reducing clinically important CV and renal outcomes in T2D patients with CKD. FIGARO-DKD is a randomized, double-blind, placebo-controlled, parallel-group, event-driven trial running in 47 countries with an expected duration of approximately 6 years. FIGARO-DKD randomized 7,437 patients with an estimated glomerular filtration rate ≥25 mL/min/1.73 m<sup>2</sup> and albuminuria (urinary albumin-to-creatinine ratio ≥30 to ≤5,000 mg/g). The study has at least 90% power to detect a 20% reduction in the risk of the primary outcome (overall two-sided significance level α = 0.05), the composite of time to first occurrence of CV death, nonfatal myocardial infarction, nonfatal stroke, or hospitalization for heart failure. <b><i>Conclusions:</i></b> FIGARO-DKD will determine whether an optimally treated cohort of T2D patients with CKD at high risk of CV and renal events will experience cardiorenal benefits with the addition of finerenone to their treatment regimen. Trial Registration: EudraCT number: 2015-000950-39; ClinicalTrials.gov identifier: NCT02545049.
DOI: 10.6084/m9.figshare.10075235.v3
title: Supplementary Material for: Design and Baseline Characteristics of the Finerenone in Reducing Cardiovascular Mortality and Morbidity in Diabetic Kidney Disease Trial

description: <b><i>Background:</i></b> Among people with diabetes, those with kidney disease have exceptionally high rates of cardiovascular (CV) morbidity and mortality and progression of their underlying kidney disease. Finerenone is a novel, nonsteroidal, selective mineralocorticoid receptor antagonist that has shown to reduce albuminuria in type 2 diabetes (T2D) patients with chronic kidney disease (CKD) while revealing only a low risk of hyperkalemia. However, the effect of finerenone on CV and renal outcomes has not yet been investigated in long-term trials. <b><i>Patients and</i></b> <b><i>Methods:</i></b> The Finerenone in Reducing CV Mortality and Morbidity in Diabetic Kidney Disease (FIGARO-DKD) trial aims to assess the efficacy and safety of finerenone compared to placebo at reducing clinically important CV and renal outcomes in T2D patients with CKD. FIGARO-DKD is a randomized, double-blind, placebo-controlled, parallel-group, event-driven trial running in 47 countries with an expected duration of approximately 6 years. FIGARO-DKD randomized 7,437 patients with an estimated glomerular filtration rate ≥25 mL/min/1.73 m<sup>2</sup> and albuminuria (urinary albumin-to-creatinine ratio ≥30 to ≤5,000 mg/g). The study has at least 90% power to detect a 20% reduction in the risk of the primary outcome (overall two-sided significance level α = 0.05), the composite of time to first occurrence of CV death, nonfatal myocardial infarction, nonfatal stroke, or hospitalization for heart failure. <b><i>Conclusions:</i></b> FIGARO-DKD will determine whether an optimally treated cohort of T2D patients with CKD at high risk of CV and renal events will experience cardiorenal benefits with the addition of finerenone to their treatment regimen. Trial Registration: EudraCT number: 2015-000950-39; ClinicalTrials.gov identifier: NCT02545049.
DOI: 10.6084/m9.figshare.10074344
title: Data file of malnutrition, health, and population statistics

description: This file contains a subset of the data about malnutrition, health, and population statistics, from the years 2000-2018. It had been made publicly available by the World Bank. For the convenience of the user of this file, the data had been transposed, so that it would be easier to import into machine learning software.
DOI: 10.6084/m9.figshare.10074284
title: Flexure Based Energy Dissipating Device in Self-Centering Braces

description: Abstract Self-centering braces, in the current stage of development can accommodate large deformation and force levels. However, there is still a need for improvement of the energy dissipation mechanisms commonly incorporated in these braces. Yield based energy dissipation systems can overcome some of the problems faced with friction-based devices, such as susceptibility to bolt relaxation, long-term creep of friction material and excessive flexing arising in the outer tubes due to friction bolts. However, in these alternative systems multi-wave buckling of the yielding core is present, which is the leading cause of an asymmetric hysteresis of the brace. Hence, in this study, U-shape flexural plates (UFPs) are analyzed as an alternative energy-dissipating device in real scale self-centering braces with a finite element modeling approach. UFP plates yield in flexure and when comparing to direct tension/compression yielding members, they show lower strain demand, resulting in a larger displacement capacity. Implementation of the UFP units in the brace produces a flag shape hysteresis with minimal residual deformation. The proposed system provides some advantages when compared to previous models in terms of increased redundancy, symmetric hysteresis and a more gradual stiffness change.
DOI: 10.6084/m9.figshare.10074281
title: Experimental and Computational Studies of the Adsorption of Furan, Pyrrole, and Thiophene on Hydroxyapatites in a Single and Ternary Component

description: Non-doped (Hap) and doped hydroxyapatites with Cu2+ and Fe2+ were synthesized and used to study the adsorption of furan (Fur), pyrrole (Pyr), and thiophene (Thi) in single and ternary component systems. Spectroscopic data and N2 isotherms indicated there were no structural alterations in Hap with the incorporation of Cu2+ and Fe2+. For both single and ternary components, the incorporation of the metal ions resulted in an adsorption increment consistent with the hard-soft acid-base concept. When comparing the systems, there is an inversion with Thi (5.41 mg g-1) and Fur (5.51 mg g-1) being the most adsorbed species in the single and ternary components, respectively. Monte Carlo simulations helped explain the observed experimental trends. While the electrostatic effect seems to prevail in the single system, in the ternary one the mass transport phenomenon is also operative implying greater availability of Fur on surface leading to its higher adsorption efficiency.
DOI: 10.6084/m9.figshare.10074284.v1
title: Flexure Based Energy Dissipating Device in Self-Centering Braces

description: Abstract Self-centering braces, in the current stage of development can accommodate large deformation and force levels. However, there is still a need for improvement of the energy dissipation mechanisms commonly incorporated in these braces. Yield based energy dissipation systems can overcome some of the problems faced with friction-based devices, such as susceptibility to bolt relaxation, long-term creep of friction material and excessive flexing arising in the outer tubes due to friction bolts. However, in these alternative systems multi-wave buckling of the yielding core is present, which is the leading cause of an asymmetric hysteresis of the brace. Hence, in this study, U-shape flexural plates (UFPs) are analyzed as an alternative energy-dissipating device in real scale self-centering braces with a finite element modeling approach. UFP plates yield in flexure and when comparing to direct tension/compression yielding members, they show lower strain demand, resulting in a larger displacement capacity. Implementation of the UFP units in the brace produces a flag shape hysteresis with minimal residual deformation. The proposed system provides some advantages when compared to previous models in terms of increased redundancy, symmetric hysteresis and a more gradual stiffness change.
DOI: 10.6084/m9.figshare.10074281.v1
title: Experimental and Computational Studies of the Adsorption of Furan, Pyrrole, and Thiophene on Hydroxyapatites in a Single and Ternary Component

description: Non-doped (Hap) and doped hydroxyapatites with Cu2+ and Fe2+ were synthesized and used to study the adsorption of furan (Fur), pyrrole (Pyr), and thiophene (Thi) in single and ternary component systems. Spectroscopic data and N2 isotherms indicated there were no structural alterations in Hap with the incorporation of Cu2+ and Fe2+. For both single and ternary components, the incorporation of the metal ions resulted in an adsorption increment consistent with the hard-soft acid-base concept. When comparing the systems, there is an inversion with Thi (5.41 mg g-1) and Fur (5.51 mg g-1) being the most adsorbed species in the single and ternary components, respectively. Monte Carlo simulations helped explain the observed experimental trends. While the electrostatic effect seems to prevail in the single system, in the ternary one the mass transport phenomenon is also operative implying greater availability of Fur on surface leading to its higher adsorption efficiency.
DOI: 10.6084/m9.figshare.10074269
title: Effects of Frequency, Temperature and Test Duration in the Viscoelasticity of Brazilian Hardwoods Used in Handmade Musical Instruments

description: This study aims to make a comprehensive analysis on the viscoelastic behavior of typical tropical hardwoods and its influences in making musical instruments. For that a Dynamic-Mechanical Analysis was done and the mechanical parameters dependence on test control parameters like temperature, frequency and test duration time were measured. For Dalbergia Nigra the final value of Module of Elasticity (MOE) was 17551.0MPa and 0.022020 for tangent delta (tg(δ)), but a great variation in those parameters was observed during the tests, for all species the MOE increases and tg(δ) decreases, even with constant temperatures, which may be caused by water loss. Besides that, a discussion was made relating the obtained data and historical knowledge about the usages of the studied woods for musical instruments manufacture, and density was shown as the main variable for that purpose.
DOI: 10.6084/m9.figshare.10074254
title: Accuracy of breast magnetic resonance imaging in evaluating the response to neoadjuvant chemotherapy: a study of 310 cases at a cancer center

description: Abstract Objective: To evaluate the accuracy of magnetic resonance imaging (MRI) of the breasts in the identification of a pathological complete response in patients with breast cancer undergoing neoadjuvant chemotherapy (NAC). Materials and Methods: This was a single-center, retrospective, observational study designed to validate a diagnostic test. The following variables were evaluated: age; results of the histological and immunohistochemical analysis of the biopsy; post-NAC MRI findings; and results of the histological analysis of the surgical specimen, using the residual cancer burden index. The radiological response, as assessed by MRI, was compared with the pathological response, as assessed by histological analysis of the surgical specimen (the gold standard method). Results: We evaluated 310 tumors in 308 patients. The mean age of the patients was 47 years (range, 27-85 years). For identifying a pathological complete response, breast MRI had an overall accuracy of 79%, with a sensitivity of 75%, specificity of 83%, positive predictive value of 75%, and negative predictive value of 83%. When that accuracy was stratified by molecular subtype, it was best for the HER2 subtype, with a sensitivity and specificity of 82% and 89%, respectively, followed by the triple-negative subtype, with a sensitivity and specificity of 78% and 83%, respectively. Conclusion: Breast MRI showed good accuracy in the prediction of a pathological complete response after NAC. The sensitivity and positive predictive value were highest for the HER2 and triple-negative subtypes.
DOI: 10.6084/m9.figshare.10074257
title: Antimicrobial Effects of Silver(I) and Bismuth(III) Complexes with Secnidazole-Derived Schiff Base Ligands: the Role of the Nitro Group Reduction

description: [Ag(HL)NO3] complexes (1-4) were obtained with (E)-N’-(1-(2-methyl-5-nitro-1H-imidazol-1-yl)propan-2-ylidene)acetohydrazide (HL1); (E)-N’-(1-(2-methyl-5-nitro-1H-imidazol-1-yl)propan-2-ylidene)benzohydrazide (HL2); (E)-2-(1-(2-methyl-5-nitro-1H-imidazol-1-yl)propan-2-ylidene)hydrazinecarbothioamide (HL3) and (E)-N-methyl-2-(1-(2-methyl-5-nitro-1H-imidazol-1-yl)propan-2-ylidene)hydrazinecarbothioamide (HL4) secnidazole-derived Schiff bases. In addition, complexes [Bi(HL3)Cl3] (5) and [Bi(HL4)Cl3] (6) were also prepared. The silver(I) complexes (1-4) showed antifungal activity against Candida fungal strains while the uncomplexed ligands and the bismuth(III) complexes (5-6) were inactive, suggesting that the antifungal effects are probably due to the presence of silver. Although the Schiff base ligands and complexes (1-6) revealed to be inactive against Gram-positive and Gram-negative aerobic bacteria, all compounds exhibited potent antimicrobial effects against several anaerobic bacterial strains, indicating that their mode of action probably involves anaerobic bio reduction of the nitro group, with formation of metabolites which are toxic to the microorganisms. Electrochemistry studies showed that bio reduction of the nitro group is favored in complexes (1-6) in comparison to the free ligands, which might, at least in part, explain their increased antimicrobial effects.
DOI: 10.6084/m9.figshare.10074257.v1
title: Antimicrobial Effects of Silver(I) and Bismuth(III) Complexes with Secnidazole-Derived Schiff Base Ligands: the Role of the Nitro Group Reduction

description: [Ag(HL)NO3] complexes (1-4) were obtained with (E)-N’-(1-(2-methyl-5-nitro-1H-imidazol-1-yl)propan-2-ylidene)acetohydrazide (HL1); (E)-N’-(1-(2-methyl-5-nitro-1H-imidazol-1-yl)propan-2-ylidene)benzohydrazide (HL2); (E)-2-(1-(2-methyl-5-nitro-1H-imidazol-1-yl)propan-2-ylidene)hydrazinecarbothioamide (HL3) and (E)-N-methyl-2-(1-(2-methyl-5-nitro-1H-imidazol-1-yl)propan-2-ylidene)hydrazinecarbothioamide (HL4) secnidazole-derived Schiff bases. In addition, complexes [Bi(HL3)Cl3] (5) and [Bi(HL4)Cl3] (6) were also prepared. The silver(I) complexes (1-4) showed antifungal activity against Candida fungal strains while the uncomplexed ligands and the bismuth(III) complexes (5-6) were inactive, suggesting that the antifungal effects are probably due to the presence of silver. Although the Schiff base ligands and complexes (1-6) revealed to be inactive against Gram-positive and Gram-negative aerobic bacteria, all compounds exhibited potent antimicrobial effects against several anaerobic bacterial strains, indicating that their mode of action probably involves anaerobic bio reduction of the nitro group, with formation of metabolites which are toxic to the microorganisms. Electrochemistry studies showed that bio reduction of the nitro group is favored in complexes (1-6) in comparison to the free ligands, which might, at least in part, explain their increased antimicrobial effects.
DOI: 10.6084/m9.figshare.10074269.v1
title: Effects of Frequency, Temperature and Test Duration in the Viscoelasticity of Brazilian Hardwoods Used in Handmade Musical Instruments

description: This study aims to make a comprehensive analysis on the viscoelastic behavior of typical tropical hardwoods and its influences in making musical instruments. For that a Dynamic-Mechanical Analysis was done and the mechanical parameters dependence on test control parameters like temperature, frequency and test duration time were measured. For Dalbergia Nigra the final value of Module of Elasticity (MOE) was 17551.0MPa and 0.022020 for tangent delta (tg(δ)), but a great variation in those parameters was observed during the tests, for all species the MOE increases and tg(δ) decreases, even with constant temperatures, which may be caused by water loss. Besides that, a discussion was made relating the obtained data and historical knowledge about the usages of the studied woods for musical instruments manufacture, and density was shown as the main variable for that purpose.
DOI: 10.6084/m9.figshare.10074254.v1
title: Accuracy of breast magnetic resonance imaging in evaluating the response to neoadjuvant chemotherapy: a study of 310 cases at a cancer center

description: Abstract Objective: To evaluate the accuracy of magnetic resonance imaging (MRI) of the breasts in the identification of a pathological complete response in patients with breast cancer undergoing neoadjuvant chemotherapy (NAC). Materials and Methods: This was a single-center, retrospective, observational study designed to validate a diagnostic test. The following variables were evaluated: age; results of the histological and immunohistochemical analysis of the biopsy; post-NAC MRI findings; and results of the histological analysis of the surgical specimen, using the residual cancer burden index. The radiological response, as assessed by MRI, was compared with the pathological response, as assessed by histological analysis of the surgical specimen (the gold standard method). Results: We evaluated 310 tumors in 308 patients. The mean age of the patients was 47 years (range, 27-85 years). For identifying a pathological complete response, breast MRI had an overall accuracy of 79%, with a sensitivity of 75%, specificity of 83%, positive predictive value of 75%, and negative predictive value of 83%. When that accuracy was stratified by molecular subtype, it was best for the HER2 subtype, with a sensitivity and specificity of 82% and 89%, respectively, followed by the triple-negative subtype, with a sensitivity and specificity of 78% and 83%, respectively. Conclusion: Breast MRI showed good accuracy in the prediction of a pathological complete response after NAC. The sensitivity and positive predictive value were highest for the HER2 and triple-negative subtypes.
DOI: 10.6084/m9.figshare.10074245
title: Multiple sclerosis has a distinct lipid signature in plasma and cerebrospinal fluid

description: ABSTRACT The diagnosis of multiple sclerosis (MS) has changed over the last decade, but remains a composite of clinical assessment and magnetic resonance imaging to prove dissemination of lesions in time and space. The intrathecal synthesis of immunoglobulin may be a nonspecific marker and there are no plasma biomarkers that are useful in the diagnosis of MS, presenting additional challenges to their early detection. Methods We performed a preliminary untargeted qualitative lipidomics mass spectrometry analysis, comparing cerebrospinal fluid (CSF) and plasma samples from patients with MS, other inflammatory neurological diseases and idiopathic intracranial hypertension. Results Lipid identification revealed that fatty acids and sphingolipids were the most abundant classes of lipids in the CSF and that glycerolipids and fatty acids were the main class of lipids in the plasma of patients with MS. The area under the curve was 0.995 (0.912–1) and 0.78 (0.583–0.917), respectively. The permutation test indicated that this ion combination was useful for distinguishing MS from other inflammatory diseases (p &lt; 0.001 and 0.055, respectively). Conclusion This study concluded that the CSF and plasma from patients with MS bear a unique lipid signature that can be useful as a diagnostic biomarker.
DOI: 10.6084/m9.figshare.10074248
title: Salomón Hakim: the man behind normal pressure hydrocephalus

description: ABSTRACT The illustrious Colombian Professor Salomón Hakim provided the annals of neurology with one of the most brilliant and original bodies of research on record, developing the concept of normal pressure hydrocephalus, as well as proving that ventricular shunting is an effective treatment. Thus, Professor Hakim proved that some of the dementias, at that time considered senile, could be successfully treated. Here the authors present an historical review of his main contributions, which continue to influence the study of dementia to this day.
DOI: 10.6084/m9.figshare.10074239
title: 140 Years of the Leçons sur l’histologie du système nerveux: the pioneering description of the nodes of Ranvier

description: ABSTRACT This paper reviews aspects of the life and work of Professor Louis Ranvier 140 years after the publication of Leçons sur l’histologie du système nerveux, published in 1878, and shows the importance of the histological description of myelinated fibers of the nodes of Ranvier.
DOI: 10.6084/m9.figshare.10074239.v1
title: 140 Years of the Leçons sur l’histologie du système nerveux: the pioneering description of the nodes of Ranvier

description: ABSTRACT This paper reviews aspects of the life and work of Professor Louis Ranvier 140 years after the publication of Leçons sur l’histologie du système nerveux, published in 1878, and shows the importance of the histological description of myelinated fibers of the nodes of Ranvier.
DOI: 10.6084/m9.figshare.10074245.v1
title: Multiple sclerosis has a distinct lipid signature in plasma and cerebrospinal fluid

description: ABSTRACT The diagnosis of multiple sclerosis (MS) has changed over the last decade, but remains a composite of clinical assessment and magnetic resonance imaging to prove dissemination of lesions in time and space. The intrathecal synthesis of immunoglobulin may be a nonspecific marker and there are no plasma biomarkers that are useful in the diagnosis of MS, presenting additional challenges to their early detection. Methods We performed a preliminary untargeted qualitative lipidomics mass spectrometry analysis, comparing cerebrospinal fluid (CSF) and plasma samples from patients with MS, other inflammatory neurological diseases and idiopathic intracranial hypertension. Results Lipid identification revealed that fatty acids and sphingolipids were the most abundant classes of lipids in the CSF and that glycerolipids and fatty acids were the main class of lipids in the plasma of patients with MS. The area under the curve was 0.995 (0.912–1) and 0.78 (0.583–0.917), respectively. The permutation test indicated that this ion combination was useful for distinguishing MS from other inflammatory diseases (p &lt; 0.001 and 0.055, respectively). Conclusion This study concluded that the CSF and plasma from patients with MS bear a unique lipid signature that can be useful as a diagnostic biomarker.
DOI: 10.6084/m9.figshare.10074248.v1
title: Salomón Hakim: the man behind normal pressure hydrocephalus

description: ABSTRACT The illustrious Colombian Professor Salomón Hakim provided the annals of neurology with one of the most brilliant and original bodies of research on record, developing the concept of normal pressure hydrocephalus, as well as proving that ventricular shunting is an effective treatment. Thus, Professor Hakim proved that some of the dementias, at that time considered senile, could be successfully treated. Here the authors present an historical review of his main contributions, which continue to influence the study of dementia to this day.
DOI: 10.6084/m9.figshare.10074224
title: The Subjectivity of Well-being in Health

description: Abstract In this paper we will illustrate the accessibility to a subjective state of well-being from two clinical situations. We will observe how these two patients, one suffered a stroke and one displaying a neurodegenerative disease, were able to overcome their handicap and deploy their creative potential, past the psychometric assessment phase.