cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.12368927
title: Modeling Pulsatility Index nomograms from different maternal and fetal vessels by quantile regression at 24–40 weeks of gestation: a prospective cross-sectional study

description: Recent evidences highlight a considerable heterogeneity in the methodology of previously published studies reporting reference ranges for maternal and fetal Dopplers, which may have relevant implications in clinical practice. In view of these limitations, a standardized methodology to construct Doppler charts has been proposed. The aim of this study was to develop charts for pulsatility index (PI) of maternal and fetal Dopplers based upon the recently proposed standardized methodology and using quantile regression. Prospective cross-sectional study including 2516 low-risk singleton pregnancies between 24 and 40 weeks of gestation. The mean uterine, umbilical (UA), middle cerebral (MCA) and their ratio (cerebroplacental ratio, CPR) centile values were established by quantile regression in the considered gestational interval. Interclass correlation coefficient (ICC) of each maternal and fetal vessel was also computed to assess the intra- and inter-observer agreement of the results. There was a good intra- and inter-observer agreement for each of the explored vessels (ICC &gt;0.92 and &gt;0.91 for a single and two observers, respectively). The 5th, 10th, 50th, 90th and 95th centiles of the reference range for gestation were constructed by quantile regression and compared to previously established reference charts. All the Doppler indices significantly changed with gestation. Second-degree polynomial regression models better described the changes with gestation in PCR and MCA PI values while a linear model better predicted the changes of other Doppler indices with advancing gestation. When compared to other studies reporting reference ranges for maternal and fetal Dopplers, the present charts showed similar median values but different distribution from the median. We provided prospective charts of maternal and fetal Dopplers based upon a previously proposed standardized methodology and using quantile regression. When compared to previously published studies, these new charts showed similar median values but different deviations from the median which may help in better differentiating cases at higher risk of placental insufficiency and adverse perinatal outcome.
DOI: 10.6084/m9.figshare.12368927.v1
title: Modeling Pulsatility Index nomograms from different maternal and fetal vessels by quantile regression at 24–40 weeks of gestation: a prospective cross-sectional study

description: Recent evidences highlight a considerable heterogeneity in the methodology of previously published studies reporting reference ranges for maternal and fetal Dopplers, which may have relevant implications in clinical practice. In view of these limitations, a standardized methodology to construct Doppler charts has been proposed. The aim of this study was to develop charts for pulsatility index (PI) of maternal and fetal Dopplers based upon the recently proposed standardized methodology and using quantile regression. Prospective cross-sectional study including 2516 low-risk singleton pregnancies between 24 and 40 weeks of gestation. The mean uterine, umbilical (UA), middle cerebral (MCA) and their ratio (cerebroplacental ratio, CPR) centile values were established by quantile regression in the considered gestational interval. Interclass correlation coefficient (ICC) of each maternal and fetal vessel was also computed to assess the intra- and inter-observer agreement of the results. There was a good intra- and inter-observer agreement for each of the explored vessels (ICC &gt;0.92 and &gt;0.91 for a single and two observers, respectively). The 5th, 10th, 50th, 90th and 95th centiles of the reference range for gestation were constructed by quantile regression and compared to previously established reference charts. All the Doppler indices significantly changed with gestation. Second-degree polynomial regression models better described the changes with gestation in PCR and MCA PI values while a linear model better predicted the changes of other Doppler indices with advancing gestation. When compared to other studies reporting reference ranges for maternal and fetal Dopplers, the present charts showed similar median values but different distribution from the median. We provided prospective charts of maternal and fetal Dopplers based upon a previously proposed standardized methodology and using quantile regression. When compared to previously published studies, these new charts showed similar median values but different deviations from the median which may help in better differentiating cases at higher risk of placental insufficiency and adverse perinatal outcome.
DOI: 10.6084/m9.figshare.12333083
title: Coronavirus and pregnancy: How can three-dimensional printing laboratories help?

description: Coronavirus and pregnancy: How can three-dimensional printing laboratories help?
DOI: 10.6084/m9.figshare.12333083.v1
title: Coronavirus and pregnancy: How can three-dimensional printing laboratories help?

description: Coronavirus and pregnancy: How can three-dimensional printing laboratories help?
DOI: 10.6084/m9.figshare.17158139
title: Temporal trends in lung cancer survival: a population-based study

description: Lung cancer is the number one cancer-related cause of death in Sweden and worldwide. In most countries, five-year survival estimates vary between 10% and 20% with evidence of improved survival over time. Over the last decades, the management of lung cancer has changed including the introduction of national guidelines, new diagnostic procedures and treatments. This study aimed to investigate temporal trends in lung cancer survival both overall and in subgroups defined by established prognostic factors (i.e., sex, stage, histopathology and smoking history). We estimated one-, two-, and five-year relative survival, and excess mortality, in patients diagnosed with squamous cell carcinoma or adenocarcinoma of the lung between 1995 and 2016 in Sweden. We used population-based information available in a national lung cancer research database (LCBaSe) generated by cross-linkage between the Swedish National Lung Cancer Register and several Swedish health and sociodemographic registers. We included 36,935 patients diagnosed with squamous cell carcinoma or adenocarcinoma of the lung between 1995 and 2016. The overall one-, two- and five-year survival estimates increased between 1995 and 2016, from 38% to 53%, 21% to 37%, and 14% to 24%, respectively. Over the study period, we also found improved survival in subgroups, for example in patients with stages III-IV disease, patients with adenocarcinoma, and never-smokers. The excess mortality decreased over the study period, both overall and in all subgroups. Lung cancer survival increased over time in the overall lung cancer population. Of special note was evidence of improved survival in patients with stage IV disease. Our results corroborate a previously observed global trend of improved survival in patients with lung cancer.
DOI: 10.6084/m9.figshare.19307292
title: Etoposide-containing regimens for the treatment of critically ill patients with hematological malignancy-related hemophagocytic lymphohistiocytosis

description: Etoposide-containing regimens for the treatment of critically ill patients with hematological malignancy-related hemophagocytic lymphohistiocytosis
DOI: 10.6084/m9.figshare.19114823
title: Age-specific incidence, treatment, and survival trends in esophageal cancer: a Dutch population-based cohort study

description: Data on the age-specific incidence of esophageal cancer are lacking. Our aim was to investigate the age-stratified incidence, treatment, and survival trends of esophageal cancer in the Netherlands, with a focus on adults &lt;50 years. Patients diagnosed with esophageal cancer were included from the nationwide Netherlands Cancer Registry (1989–2018). Follow-up data were available until 31 December 2018. Annual percentage changes of incidence were analyzed according to age group (&lt;50, 50–74, and ≥75 years) and histology type: adenocarcinoma (EAC) and squamous cell carcinoma (ESCC). Treatment trends and relative survival rates (RSR) were estimated by age and stage grouping. A total 59,584 patients were included. In adults &lt;50 years, EAC incidence tripled (mean increase per year: males 1.5%, females 3%), while the incidence of ESCC decreased (mean decrease per year: males −5.3%, females −4.3%). Patients &lt;50 years more often presented with advanced disease stages compared to older patients and were more likely to receive multimodality treatments. Most patients &lt;50 years with potentially curable disease were treated with neoadjuvant chemoradiotherapy followed by surgery compared to patients 50–74 and ≥75 years (74% vs. 55% vs. 15%, respectively; <i>p</i> &lt; .001), and received more frequent systemic therapy once staged with palliative disease (72% vs. 54% vs. 19%, respectively; <i>p</i> &lt; .001). The largest RSR improvement was seen in patients &lt;50 years with early-stage (five years: +47%), potentially curable (five years: +22%), and palliative disease (one year: +11%). Over time, a trend of increasing survival difference was seen between patients &lt;50 and ≥75 years with potentially curable (five-year difference: 17% to 27%) and palliative disease (one-year difference: 11% to 20%). The incidence of EAC is increasing in adults &lt;50 years in the Netherlands. Differences in the use of multimodality treatments with curative or life-prolonging intent in different age categories may account for increasing survival gaps.
DOI: 10.6084/m9.figshare.19114823.v1
title: Age-specific incidence, treatment, and survival trends in esophageal cancer: a Dutch population-based cohort study

description: Data on the age-specific incidence of esophageal cancer are lacking. Our aim was to investigate the age-stratified incidence, treatment, and survival trends of esophageal cancer in the Netherlands, with a focus on adults &lt;50 years. Patients diagnosed with esophageal cancer were included from the nationwide Netherlands Cancer Registry (1989–2018). Follow-up data were available until 31 December 2018. Annual percentage changes of incidence were analyzed according to age group (&lt;50, 50–74, and ≥75 years) and histology type: adenocarcinoma (EAC) and squamous cell carcinoma (ESCC). Treatment trends and relative survival rates (RSR) were estimated by age and stage grouping. A total 59,584 patients were included. In adults &lt;50 years, EAC incidence tripled (mean increase per year: males 1.5%, females 3%), while the incidence of ESCC decreased (mean decrease per year: males −5.3%, females −4.3%). Patients &lt;50 years more often presented with advanced disease stages compared to older patients and were more likely to receive multimodality treatments. Most patients &lt;50 years with potentially curable disease were treated with neoadjuvant chemoradiotherapy followed by surgery compared to patients 50–74 and ≥75 years (74% vs. 55% vs. 15%, respectively; <i>p</i> &lt; .001), and received more frequent systemic therapy once staged with palliative disease (72% vs. 54% vs. 19%, respectively; <i>p</i> &lt; .001). The largest RSR improvement was seen in patients &lt;50 years with early-stage (five years: +47%), potentially curable (five years: +22%), and palliative disease (one year: +11%). Over time, a trend of increasing survival difference was seen between patients &lt;50 and ≥75 years with potentially curable (five-year difference: 17% to 27%) and palliative disease (one-year difference: 11% to 20%). The incidence of EAC is increasing in adults &lt;50 years in the Netherlands. Differences in the use of multimodality treatments with curative or life-prolonging intent in different age categories may account for increasing survival gaps.
DOI: 10.6084/m9.figshare.19307292.v1
title: Etoposide-containing regimens for the treatment of critically ill patients with hematological malignancy-related hemophagocytic lymphohistiocytosis

description: Etoposide-containing regimens for the treatment of critically ill patients with hematological malignancy-related hemophagocytic lymphohistiocytosis
DOI: 10.6084/m9.figshare.19316642
title: External validation of the MSKCC nomogram to estimate five-year overall survival after surgery for stage I–III colon cancer in a Dutch population

description: The Memorial Sloan Kettering Cancer Centre (MSKCC) nomogram has been developed to estimate five-year overall survival (OS) after curative-intent surgery of colon cancer based on age, sex, T stage, differentiation grade, number of positive and examined regional lymph nodes. This is the first evaluation of the performance of the MSKCC model in a European population regarding prediction of OS. Population-based data from patients with stage I–III colon cancer diagnosed between 2010 and 2016 were obtained from the Netherlands Cancer Registry (NCR) for external validation of the MSKCC prediction model. Five-year survival probabilities were estimated for all patients in our dataset by using the MSKCC prediction equation. Histogram density plots were created to depict the distribution of the estimated probability and prognostic index. The performance of the model was evaluated in terms of its overall performance, discrimination, and calibration. A total of 39,805 patients were included. Five-year OS was 71.9% (95% CI 71.5; 72.3) (11,051 events) with a median follow up of 5.6 years (IQR 4.1; 7.7). The Brier score was 0.10 (95% CI 0.10; 0.10). The C-index was 0.75 (95% CI 0.75; 0.76). The calibration measures and plot indicated that the model slightly overestimated observed mortality (observed/expected ratio = 0.86 [95% CI 0.86; 0.87], calibration intercept = −0.14 [95% CI −0.16; −0.11], and slope 1.07 [95% CI 1.05; 1.09], ICI = 0.04, E50 = 0.04, and E90 = 0.05). The external validation of the MSKCC prediction nomogram in a large Dutch cohort supports the use of this practical tool in the European patient population. These personalised estimated survival probabilities may support clinicians when informing patients about prognosis. Adding potential relevant prognostic factors to the model, such as primary tumour location, might further improve the model.
DOI: 10.6084/m9.figshare.19316642.v1
title: External validation of the MSKCC nomogram to estimate five-year overall survival after surgery for stage I–III colon cancer in a Dutch population

description: The Memorial Sloan Kettering Cancer Centre (MSKCC) nomogram has been developed to estimate five-year overall survival (OS) after curative-intent surgery of colon cancer based on age, sex, T stage, differentiation grade, number of positive and examined regional lymph nodes. This is the first evaluation of the performance of the MSKCC model in a European population regarding prediction of OS. Population-based data from patients with stage I–III colon cancer diagnosed between 2010 and 2016 were obtained from the Netherlands Cancer Registry (NCR) for external validation of the MSKCC prediction model. Five-year survival probabilities were estimated for all patients in our dataset by using the MSKCC prediction equation. Histogram density plots were created to depict the distribution of the estimated probability and prognostic index. The performance of the model was evaluated in terms of its overall performance, discrimination, and calibration. A total of 39,805 patients were included. Five-year OS was 71.9% (95% CI 71.5; 72.3) (11,051 events) with a median follow up of 5.6 years (IQR 4.1; 7.7). The Brier score was 0.10 (95% CI 0.10; 0.10). The C-index was 0.75 (95% CI 0.75; 0.76). The calibration measures and plot indicated that the model slightly overestimated observed mortality (observed/expected ratio = 0.86 [95% CI 0.86; 0.87], calibration intercept = −0.14 [95% CI −0.16; −0.11], and slope 1.07 [95% CI 1.05; 1.09], ICI = 0.04, E50 = 0.04, and E90 = 0.05). The external validation of the MSKCC prediction nomogram in a large Dutch cohort supports the use of this practical tool in the European patient population. These personalised estimated survival probabilities may support clinicians when informing patients about prognosis. Adding potential relevant prognostic factors to the model, such as primary tumour location, might further improve the model.
DOI: 10.6084/m9.figshare.19932193
title: Precision radiation of immune checkpoint therapy resistant melanoma metastases (PROMMEL study): study protocol for a phase II open-label multicenter trial

description: Precision radiation of immune checkpoint therapy resistant melanoma metastases (PROMMEL study): study protocol for a phase II open-label multicenter trial
DOI: 10.6084/m9.figshare.19932193.v1
title: Precision radiation of immune checkpoint therapy resistant melanoma metastases (PROMMEL study): study protocol for a phase II open-label multicenter trial

description: Precision radiation of immune checkpoint therapy resistant melanoma metastases (PROMMEL study): study protocol for a phase II open-label multicenter trial
DOI: 10.6084/m9.figshare.19672792
title: Characteristics and survival of patients with non-small cell lung cancer treated with immune-checkpoint inhibitors in the real-world: experiences from Bergen, Norway

description: Characteristics and survival of patients with non-small cell lung cancer treated with immune-checkpoint inhibitors in the real-world: experiences from Bergen, Norway
DOI: 10.6084/m9.figshare.19672792.v1
title: Characteristics and survival of patients with non-small cell lung cancer treated with immune-checkpoint inhibitors in the real-world: experiences from Bergen, Norway

description: Characteristics and survival of patients with non-small cell lung cancer treated with immune-checkpoint inhibitors in the real-world: experiences from Bergen, Norway
DOI: 10.6084/m9.figshare.20424369
title: Mytilus coruscus.zip

description: The main body of this database is the transcriptome sequencing on the gonad organs in male and female <em>Mytilus coruscus</em>.
DOI: 10.6084/m9.figshare.20424369.v3
title: Mytilus coruscus.zip

description: The main body of this database is the transcriptome sequencing on the gonad organs in male and female <em>Mytilus coruscus</em>.
DOI: 10.6084/m9.figshare.20424369.v2
title: Mytilus coruscus.zip

description: The main body of this database is the transcriptome sequencing on the gonad organs in male and female <em>Mytilus coruscus</em>.
DOI: 10.6084/m9.figshare.20424390
title: Forgetting of Distractors

description: Original data of "Forgetting of Distractors"
DOI: 10.6084/m9.figshare.20424390.v2
title: Forgetting of Distractors

description: Original data of "Forgetting of Distractors"
DOI: 10.6084/m9.figshare.20424390.v1
title: Forgetting of Distractors

description: Original data of "Forgetting of Distractors"
DOI: 10.5281/zenodo.5111988
title: GPRChinaTemp1km: 1 km monthly mean air temperature for China from January 1951 to December 2020

description: GPRChinaTemp1km is a new high-resolution (1-km) monthly gridded air temperature dataset for China from January 1951 to December 2020. The dataset includes monthly mean air temperature covering the main land area of China during 1951-2020, which was interpolated by the Gaussian process regression (GPR) method based on the meteorological station data. The monthly gridded temperature dataset was evaluated by the observed values of the meteorological stations from the China Meteorological Data Service Centre. The dataset is in GeoTIFF format in the WGS84 (EPSG:4326) coordinate system. The unit of the data is degree Celsius (°C).
DOI: 10.24400/802406/jnx0-04ra
title: MMS-1 SCM L2 Survey Quicklooks (6 hours) (PNG)

description: MMS-1 SCM survey quicklooks [0.0625-16Hz] shows from top to bottom : color coded data quality, waveforms (nT), power spectral densities (nT^2/Hz), integrated power (nT^2), time-averaged (over the 6 hours) Fourier spectra (nT^2/Hz) with SCM ground noise level (in black) for reference. All data are plotted in GSE.
DOI: 10.24400/802406/0gdy-yx8a
title: MMS-1 SCM L2 Burst Quicklooks (PNG)

description: MMS-1 SCM burst quicklooks [1-4096Hz] shows from top to bottom : color coded data quality, waveforms (nT), power spectral densities (nT^2/Hz), integrated power (nT^2), time-averaged (over the burst time period) Fourier spectra (nT^2/Hz) with SCM ground noise level (in black) for reference. All data are plotted in GSE.
DOI: 10.24400/802406/a26j-h0zf
title: MMS-1 SCM L2 High-Speed Burst Quicklooks (PNG)

description: MMS-1 SCM high-speed burst quicklooks [32-8192Hz] shows from top to bottom : color coded data quality, waveforms (nT), power spectral densities (nT^2/Hz), integrated power (nT^2), time-averaged (over the burst time period) Fourier spectra (nT^2/Hz) with SCM ground noise level (in black) for reference. All data are plotted in GSE.
DOI: 10.6084/m9.figshare.17198792.v1
title: Isotopic and chemical facies for assessing the shallow water table aquifer quality in Goly Region, White Nile State, Sudan: focusing on nitrate source apportionment and human health risk

description: Groundwater from the shallow water table aquifer is the main supply of drinking water for residents in Goly Region, White Nile State, Sudan. The residents have complained about groundwater quality. This study aims to evaluate groundwater quality in in Goly Region and to assess the possible health risk of toxicants with focusing on nitrates. The study examined groundwater from wells distributed in 23 sites for hydrogeological, physiochemical, and isotopic facies. The ranges of facies levels (mg/L) were as follows: nitrate (6.2–655.6), fluoride (0.00–2.16), sodium (36.4–293.2), total dissolved solids (349–908), carbonate (0.00–24.0), nitrite (0.026–0.828), sulfate (1.00–77.00), ammonia (0.00–0.40), and chloride (12.78–42.60), besides pH (6.93–8.48). According to the National Sudanese Guidelines and the World Health Organization guidelines, 12 wells recorded unhealthy levels for nitrate, 1 well recorded unhealthy level for fluoride, and 2 wells recorded unhealthy levels for sodium, while all wells recorded healthy levels for the rest of facies. Additionally, groundwater consumption from 14 sites put both children and adults at potential health risk from nitrates based on hazard risk index. The Piper diagram shows that the trend of cation exchange in the aquifer was from (calcium + magnesium) to (sodium + potassium). Significant positive correlations were observed between several parameters, e.g. the combinations of static water level-depth (0.51), electrical conductivity (EC)-nitrate (0.60), EC-sulfate (0.73), EC-fluoride (0.55), EC-chloride (0.76), EC-sodium (0.84), pH-fluoride (0.73), and pH-sodium (0.59). The principal component analysis of the examined facies shows that the first two principal components, which have similar loadings (≈ 22% of each), represented natural and anthropogenic sources of major ions. The isotopes levels and relationship of δ<sup>15</sup>N and δ<sup>18</sup>O revealed that nitrate contamination was from animal waste and/or sewage. The relation between δ<sup>18</sup>O and δ<sup>2</sup>H isotopes of water demonstrates that groundwater samples were deviated from Meteoric Line of the Sudan and Global Meteoric Water Line.