cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.28141388
title: Supplementary Material for: Direct STAT3 and STAT5 Inhibition Overcomes Treatment Resistance in a Murine Derived In Vitro Model of Acute Lymphoblastic Leukaemia driven by ETV6::JAK2

description: ABSTRACT
INTRODUCTION
ETV6::JAK2 is a fusion known to drive Acute Lymphoblastic Leukaemia (ALL) in the presence of other genomic lesions which define the JAK/STAT class of Philadelphia-like Acute Lymphoblastic Leukaemia (Ph-like ALL). Ph-like ALL comprises approximately 15% of ALL. Patients with mutations or gene fusions signaling through the JAK/STAT pathway have particularly poor prognosis. Emerging treatments targeting JAK2 fusions and mutations are promising and phase 3 clinical trials are in progress. However, with widespread use of JAK2 inhibitors, it is important to anticipate and manage resistance mechanisms. The JAK2 p.G993A mutation confers resistance in vitro, even to high dose JAK2 inhibitors such as ruxolitinib. We postulated that direct inhibition of STAT3 and STAT5, downstream from JAK2, may overcome resistance.

METHODS
Murine derived IL-3 dependent Ba/F3 cells transfected with ETV6::JAK2 containing a p.G993A mutation were used in this study. These cells were confirmed to demonstrate IL-3 independence and ruxolitinib resistance prior to use in experiments. An inhibitor-response assay was conducted using differing concentrations of SH-4-54 and pimozide (STAT3/5 inhibitors) applied to ETV6::JAK2 p.G993A cells and two control cell lines. 

RESULTS
SH-4-54 and pimozide were effective against ETV6::JAK2 p.G993A cells with median lethal doses (LD50) of 296nM for SH-4-54 and 455nM for pimozide. Both drugs demonstrated a lesser effect on empty vector Ba/F3 cells, with an LD50 of 371nM for SH-4-54 and 596nM for pimozide. Neither drug demonstrated significant effect on non-JAK/STAT activated KG-1a myeloid cells at doses near the LD50.
CONCLUSION
SH-4-54 and pimozide both overcame treatment resistance in our in-vitro model of JAK/STAT driven Ph-like ALL with a mutation conferring JAK2 inhibitor resistance. While SH-4-54 demonstrates greater potency than pimozide, pimozide may be a more promising option given its demonstrated safety profile in humans. Direct STAT3 and STAT5 inhibition may be an effective approach for overcoming inevitable JAK2 inhibitor resistance-conferring mutations in patients with the poor prognostic subtype of JAK/STAT class Ph-like ALL.
DOI: 10.6084/m9.figshare.28141388.v1
title: Supplementary Material for: Direct STAT3 and STAT5 Inhibition Overcomes Treatment Resistance in a Murine Derived In Vitro Model of Acute Lymphoblastic Leukaemia driven by ETV6::JAK2

description: ABSTRACT
INTRODUCTION
ETV6::JAK2 is a fusion known to drive Acute Lymphoblastic Leukaemia (ALL) in the presence of other genomic lesions which define the JAK/STAT class of Philadelphia-like Acute Lymphoblastic Leukaemia (Ph-like ALL). Ph-like ALL comprises approximately 15% of ALL. Patients with mutations or gene fusions signaling through the JAK/STAT pathway have particularly poor prognosis. Emerging treatments targeting JAK2 fusions and mutations are promising and phase 3 clinical trials are in progress. However, with widespread use of JAK2 inhibitors, it is important to anticipate and manage resistance mechanisms. The JAK2 p.G993A mutation confers resistance in vitro, even to high dose JAK2 inhibitors such as ruxolitinib. We postulated that direct inhibition of STAT3 and STAT5, downstream from JAK2, may overcome resistance.

METHODS
Murine derived IL-3 dependent Ba/F3 cells transfected with ETV6::JAK2 containing a p.G993A mutation were used in this study. These cells were confirmed to demonstrate IL-3 independence and ruxolitinib resistance prior to use in experiments. An inhibitor-response assay was conducted using differing concentrations of SH-4-54 and pimozide (STAT3/5 inhibitors) applied to ETV6::JAK2 p.G993A cells and two control cell lines. 

RESULTS
SH-4-54 and pimozide were effective against ETV6::JAK2 p.G993A cells with median lethal doses (LD50) of 296nM for SH-4-54 and 455nM for pimozide. Both drugs demonstrated a lesser effect on empty vector Ba/F3 cells, with an LD50 of 371nM for SH-4-54 and 596nM for pimozide. Neither drug demonstrated significant effect on non-JAK/STAT activated KG-1a myeloid cells at doses near the LD50.
CONCLUSION
SH-4-54 and pimozide both overcame treatment resistance in our in-vitro model of JAK/STAT driven Ph-like ALL with a mutation conferring JAK2 inhibitor resistance. While SH-4-54 demonstrates greater potency than pimozide, pimozide may be a more promising option given its demonstrated safety profile in humans. Direct STAT3 and STAT5 inhibition may be an effective approach for overcoming inevitable JAK2 inhibitor resistance-conferring mutations in patients with the poor prognostic subtype of JAK/STAT class Ph-like ALL.
DOI: 10.15468/dl.3bvv9z
title: Occurrence Download

description: A dataset containing 3 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Geometry POLYGON((2.06077 53.28262,30.19782 53.28262,30.19782 64.53262,2.06077 64.53262,2.06077 53.28262))",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 "TaxonKey is Squatina squatina (Linnaeus, 1758)"
 ]
}

 The dataset includes 3 records from 3 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0057715-241126133413365/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.h29tvf
title: Occurrence Download

description: A dataset containing 694 species occurrences available in GBIF matching the query:
{
 "and" : [
 "GadmGid is TUR.12.14_1",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "TaxonKey is Aves"
 ]
}

 The dataset includes 694 records from 4 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0057716-241126133413365/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.fs3b8m
title: Occurrence Download

description: A dataset containing 1205 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Cerorhinca monocerata (Pallas, 1811)",
 "Geometry POLYGON((170 20, 170 50, 120 50, 120 20, 170 20))",
 "HasCoordinate is true"
 ]
}

 The dataset includes 1205 records from 18 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0057717-241126133413365/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.smq5dy
title: Occurrence Download

description: A dataset containing 1115 species occurrences available in GBIF matching the query:
{
 "and" : [
 "DatasetKey is EOD – eBird Observation Dataset",
 "GadmGid is TGO.3.6.1_1",
 "TaxonKey is Passeriformes",
 "Year 1994-2023"
 ]
}

 The dataset includes 1115 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0057718-241126133413365/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.17909/29st-dz13
title: JWST data for TOI-5205

description: We performed the data reduction on the Stage 0 files (*_nrs1_uncal.fits) for these observations.
DOI: 10.15468/dl.33d4nf
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Alca monocerata Pallas, 1811",
 "Geometry POLYGON((170 20, 170 50, 120 50, 120 20, 170 20))",
 "HasCoordinate is true"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0057719-241126133413365/datasets/export for details.
DOI: 10.15468/dl.ryhpsm
title: Occurrence Download

description: A dataset containing 21259 species occurrences available in GBIF matching the query:
{
 "and" : [
 "DatasetKey is EOD – eBird Observation Dataset",
 "GadmGid is BRA.16.193_2",
 "TaxonKey is Passeriformes",
 "Year 1994-2023"
 ]
}

 The dataset includes 21259 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0057721-241126133413365/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.w7chrn
title: Occurrence Download

description: A dataset containing 106 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Spisula sachalinensis (Schrenck, 1862)",
 "Geometry POLYGON((170 20, 170 50, 120 50, 120 20, 170 20))",
 "HasCoordinate is true"
 ]
}

 The dataset includes 106 records from 10 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0057723-241126133413365/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.8veud3
title: Occurrence Download

description: A dataset containing 31 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Pseudocardium sachalinense",
 "Geometry POLYGON((170 20, 170 50, 120 50, 120 20, 170 20))",
 "HasCoordinate is true"
 ]
}

 The dataset includes 31 records from 9 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0057724-241126133413365/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.vhsb38
title: Occurrence Download

description: A dataset containing 7 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Cetorhinus maximus (Gunnerus, 1765)",
 "Geometry POLYGON((170 20, 170 50, 120 50, 120 20, 170 20))",
 "HasCoordinate is true"
 ]
}

 The dataset includes 7 records from 5 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0057725-241126133413365/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.pdhe2m
title: Occurrence Download

description: A dataset containing 433 species occurrences available in GBIF matching the query:
{
 "and" : [
 "DatasetKey is EOD – eBird Observation Dataset",
 "GadmGid is CHN.4.2_1",
 "TaxonKey is Passeriformes",
 "Year 1994-2023"
 ]
}

 The dataset includes 433 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0057726-241126133413365/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.pceqb2
title: Occurrence Download

description: A dataset listing the 139 species recorded in GBIF matching the query:
{
 "and" : [
 "Continent is South America",
 "Country is Chile",
 "IucnRedListCategory is EN"
 ]
}

 The dataset's 139 records were derived from 172 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0057711-241126133413365/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.38aaxf
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Squalus maximus Gunnerus, 1765",
 "Geometry POLYGON((170 20, 170 50, 120 50, 120 20, 170 20))",
 "HasCoordinate is true"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0057727-241126133413365/datasets/export for details.
DOI: 10.15468/dl.aq9zhe
title: Occurrence Download

description: A dataset containing 439 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Thamnaconus modestus (Günther, 1877)",
 "Geometry POLYGON((170 20, 170 50, 120 50, 120 20, 170 20))",
 "HasCoordinate is true"
 ]
}

 The dataset includes 439 records from 27 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0057729-241126133413365/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.acp45z
title: Occurrence Download

description: A dataset containing 20 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Monacanthus modestus Günther, 1877",
 "Geometry POLYGON((170 20, 170 50, 120 50, 120 20, 170 20))",
 "HasCoordinate is true"
 ]
}

 The dataset includes 20 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0057730-241126133413365/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.ccrsfq
title: Occurrence Download

description: A dataset containing 21 species occurrences available in GBIF matching the query:
{
 "and" : [
 "DatasetKey is EOD – eBird Observation Dataset",
 "GadmGid is CHN.10.9.4_1",
 "TaxonKey is Passeriformes",
 "Year 1994-2023"
 ]
}

 The dataset includes 21 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0057731-241126133413365/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.s6twpx
title: Occurrence Download

description: A dataset containing 8965 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Geometry POLYGON((43.411 40.72734,43.44879 40.71097,43.48735 40.71623,43.49198 40.75246,43.47193 40.77466,43.41023 40.75948,43.411 40.72734))",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "TaxonKey is Aves"
 ]
}

 The dataset includes 8965 records from 3 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0057733-241126133413365/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.3kzgd6
title: Occurrence Download

description: A dataset containing 10045 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Phalacrocorax capillatus (Temminck & Schlegel, 1849)",
 "Geometry POLYGON((170 20, 170 50, 120 50, 120 20, 170 20))",
 "HasCoordinate is true"
 ]
}

 The dataset includes 10045 records from 40 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0057732-241126133413365/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.56st9t
title: Occurrence Download

description: A dataset containing 1856 species occurrences available in GBIF matching the query:
{
 "and" : [
 "DatasetKey is EOD – eBird Observation Dataset",
 "GadmGid is AGO.11_1",
 "TaxonKey is Passeriformes",
 "Year 1994-2023"
 ]
}

 The dataset includes 1856 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0057734-241126133413365/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.373waz
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Carbo capillatus Temminck & Schlegel, 1850",
 "Geometry POLYGON((170 20, 170 50, 120 50, 120 20, 170 20))",
 "HasCoordinate is true"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0057735-241126133413365/datasets/export for details.
DOI: 10.15468/dl.yn9vmm
title: Occurrence Download

description: A dataset containing 657 species occurrences available in GBIF matching the query:
{
 "and" : [
 "DatasetKey is EOD – eBird Observation Dataset",
 "GadmGid is AGO.10.10_1",
 "TaxonKey is Passeriformes",
 "Year 1994-2023"
 ]
}

 The dataset includes 657 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0057736-241126133413365/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.ny4g9g
title: Occurrence Download

description: A dataset containing 101274 species occurrences available in GBIF matching the query:
{
 "and" : [
 "DatasetKey is EOD – eBird Observation Dataset",
 "GadmGid is GBR.1.13_1",
 "TaxonKey is Passeriformes",
 "Year 1994-2023"
 ]
}

 The dataset includes 101274 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0057720-241126133413365/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.hf25pc
title: Occurrence Download

description: A dataset containing 140731 species occurrences available in GBIF matching the query:
{
 "and" : [
 "BasisOfRecord is Specimen",
 "Country is Malaysia",
 "Geometry POLYGON((117.03112 7.43792,116.72136 7.19299,116.21709 6.42219,115.51832 5.72342,115.30941 5.3056,115.33823 5.09669,115.8497 4.16019,118.19813 4.10977,118.94733 4.45555,119.30752 5.01745,119.466 5.4929,117.69387 6.55186,117.39851 7.04892,117.35529 7.42351,117.03112 7.43792))",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present"
 ]
}

 The dataset includes 140731 records from 344 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0057722-241126133413365/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.xttdke
title: Occurrence Download

description: A dataset containing 668 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Uria aalge (Pontoppidan, 1763)",
 "Geometry POLYGON((170 20, 170 50, 120 50, 120 20, 170 20))",
 "HasCoordinate is true"
 ]
}

 The dataset includes 668 records from 8 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0057737-241126133413365/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.pg6r3z
title: Occurrence Download

description: A dataset containing 482 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Didymodon cordatus Jur."
 ]
}

 The dataset includes 482 records from 66 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0057738-241126133413365/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.8uj83c
title: Occurrence Download

description: A dataset containing 150 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Geometry POLYGON((7.56065 8.45106,147.99773 8.45106,147.99773 64.64996,7.56065 64.64996,7.56065 8.45106))",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 "TaxonKey is Ochotona curzoniae (Hodgson, 1858)"
 ]
}

 The dataset includes 150 records from 11 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0057739-241126133413365/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.egsk56
title: Occurrence Download

description: A dataset containing 463 species occurrences available in GBIF matching the query:
{
 "and" : [
 "DatasetKey is EOD – eBird Observation Dataset",
 "GadmGid is COD.3.6_1",
 "TaxonKey is Passeriformes",
 "Year 1994-2023"
 ]
}

 The dataset includes 463 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0057740-241126133413365/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.wcvcn5
title: Occurrence Download

description: A dataset containing 249 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Coptis chinensis Franch."
 ]
}

 The dataset includes 249 records from 23 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0057741-241126133413365/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.g53bw9
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Colymbus aalge Pontoppidan, 1763",
 "Geometry POLYGON((170 20, 170 50, 120 50, 120 20, 170 20))",
 "HasCoordinate is true"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0057742-241126133413365/datasets/export for details.
DOI: 10.15468/dl.2wk5bs
title: Occurrence Download

description: A dataset containing 6136537 species occurrences available in GBIF matching the query:
{
 "and" : [
 "DatasetKey is EOD – eBird Observation Dataset",
 "GadmGid is USA.5.19_1",
 "TaxonKey is Passeriformes",
 "Year 1994-2023"
 ]
}

 The dataset includes 6136537 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0057728-241126133413365/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.5qvty7
title: Occurrence Download

description: A dataset containing 392 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Ditrema temminckii Bleeker, 1853",
 "Geometry POLYGON((170 20, 170 50, 120 50, 120 20, 170 20))",
 "HasCoordinate is true"
 ]
}

 The dataset includes 392 records from 27 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0057743-241126133413365/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.dtdqqs
title: Occurrence Download

description: A dataset containing 1 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Ditrema jordani Franz, 1910",
 "Geometry POLYGON((170 20, 170 50, 120 50, 120 20, 170 20))",
 "HasCoordinate is true"
 ]
}

 The dataset includes 1 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0057747-241126133413365/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.7htukg
title: Occurrence Download

description: A dataset containing 30223 species occurrences available in GBIF matching the query:
{
 "and" : [
 "DatasetKey is EOD – eBird Observation Dataset",
 "GadmGid is IND.28.12_1",
 "TaxonKey is Passeriformes",
 "Year 1994-2023"
 ]
}

 The dataset includes 30223 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0057748-241126133413365/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.cxzz8f
title: Occurrence Download

description: A dataset containing 57595 species occurrences available in GBIF matching the query:
{
 "and" : [
 "DatasetKey is EOD – eBird Observation Dataset",
 "GadmGid is IND.34.49_1",
 "TaxonKey is Passeriformes",
 "Year 1994-2023"
 ]
}

 The dataset includes 57595 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0057746-241126133413365/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.