cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.17632/vf8j68t4zz.1
title: The Supplementary Files and the statistical analysis for the Manuscript titled "Abuses experienced by child laborers in workplaces in Egypt"

description: 1- (Supplementary File No. 1, Explain Egypt’s National Child Labor Survey (NCLS) sampling methods, the survey estimates, and weights)
2- (Supplementary File No. 2, Explain Egypt’s National Child Labor Survey (NCLS) questionnaires, including the three modules: the adult questionnaire, the household characteristics questionnaire, and the child questionnaire)
3- (Supplementary File No. 3, Explaining the obtained data from Egypt’s National Child Labor Survey (NCLS) about the definitions of children in employment, “working children,” and child laborers; the framework for the statistical identification of child labor; and the child laborers rates and percentages)
4- The statistical analysis file contains the descriptive statistics for the study variables and the logistic regression analysis for multivariate analysis to determine unadjusted and adjusted relationships between critical factors and the outcome.
DOI: 10.17632/524hj3w6r8.1
title: Clear-sky retrieval of atmospheric temperature and water vapor using microwave and infrared hyperspectrometers

description: This dataset includes essential matrices and retrieved clear-sky temperature and water vapor profiles for various retrieval cases, utilizing actual measurements observed by the Atmospheric Emitted Radiance Interferometer (AERI) and the High Spectral Resolution Airborne Microwave Sounder (HiSRAMS). These data can be used to generate the figures presented in the paper titled "Clear-sky Retrieval of Atmospheric Temperature and Water Vapor using Microwave and Infrared Hyperspectrometers".
DOI: 10.17632/pmtjyvmvn8.1
title: small molecule targeting α-synuclein mRNA

description: The protein α-synuclein is an important drug target for the treatment of Parkinson’s disease, but it is an intrinsically disordered protein lacking typical small molecule binding pockets.  The mRNA encoding α-synuclein (SNCA), on the other hand, has regions of ordered structure in the 5’ untranslated region (UTR) near the start codon.  Here, we present an integrated approach to identify small molecules that bind this structure and inhibit α-synuclein translation.  A drug-like, RNA-focused compound collection was studied for binding to the 5’UTR of SNCA mRNA, affording Synucleozid-2.0, a drug-like small molecule that mechanistically inhibits ribosomes from assembling onto SNCA mRNA.  We further converted it into a ribonuclease recruiting chimera (RIBOTAC) to degrade the SNCA mRNA in cells with improved potency.  RNA-seq and proteomics studies demonstrated that Synucleozid-RIBOTAC (Syn-RIBOTAC) is selective in cells.   Syn-RIBOTAC also improved ~50% of genes abnormally expressed in patient-derived iPSC-induced dopamine neurons.  The RIBOTAC optimization strategy improved the bioactivity of lead compound by at least 5-fold.  Broadly, one strategy to expand druggability of the proteome is to target the mRNAs that encode for “undruggable” proteins.  

This is the supplemental dataset for our manuscript under review.
DOI: 10.17632/pmtjyvmvn8.2
title: small molecule targeting α-synuclein mRNA

description: The protein α-synuclein is an important drug target for the treatment of Parkinson’s disease, but it is an intrinsically disordered protein lacking typical small molecule binding pockets. The mRNA encoding α-synuclein (SNCA), on the other hand, has regions of ordered structure in the 5’ untranslated region (UTR) near the start codon. Here, we present an integrated approach to identify small molecules that bind this structure and inhibit α-synuclein translation. A drug-like, RNA-focused compound collection was studied for binding to the 5’UTR of SNCA mRNA, affording Synucleozid-2.0, a drug-like small molecule that mechanistically inhibits ribosomes from assembling onto SNCA mRNA. We further converted it into a ribonuclease recruiting chimera (RIBOTAC) to degrade the SNCA mRNA in cells with improved potency. RNA-seq and proteomics studies demonstrated that Synucleozid-RIBOTAC (Syn-RIBOTAC) is selective in cells. Syn-RIBOTAC also improved ~50% of genes abnormally expressed in patient-derived iPSC-induced dopamine neurons. The RIBOTAC optimization strategy improved the bioactivity of lead compound by at least 5-fold. Broadly, one strategy to expand druggability of the proteome is to target the mRNAs that encode for “undruggable” proteins. 

This is the supplemental dataset for our manuscript currently published at PNAS (doi: 10.1073/pnas.2306682120)
DOI: 10.17632/nycwc276b9.1
title: Refining the 8th edition TNM classification for EBV related nasopharyngeal carcinoma. Du et al.

description: All study-level data, including training cohort, internal and external validation cohorts for M0 NPC patients as well as M1 NPC patietns are deposited in this dataset. Any additional information required to reanalyze the data reported in this paper is available after approval by the corresponding author and Sun Yat-sen University Cancer Center.
DOI: 10.17632/yr5kk8k7y6.1
title: VITAMIN C DETERMINATION

description: Vitamin C, also known as ascorbic acid, is one of the essential micro nutrients prevent free radicals from damaging the cells in the body. It contributes to healthy skin, bones, and connective tissues. Moreover, it aids in boosting the immune system and absorption of iron. Raw fruits and vegetables are great sources of Vitamin C which includes citrus fruits, berries, green leafy vegetables, and many more. Vitamin C determination can be done through Iodine Titration. This volumetric method allows the vitamin C to form a complex with the Iodine solution in which the iodine is the oxidizing agent. The amount of iodine solution consumed determines the amount of vitamin C present in the sample.Determining the Vitamin C content is crucial for every person, especially health-conscious ones since it is important for nutritional assessment. It must be ensured that the fruit or vegetable intake is adequate for human nutrition. In food technology, determining vitamin C is essential in food processing since it can be an indicator for any optimization in processing methods because processing methods destroy vitamin C. Additionally, it can be an indicator of food quality and freshness. The vitamin C content of a fruit or vegetable helps maintain food quality standards and ensures the production of a nutrient-dense food product.
DOI: 10.17632/8mfxrz324p.1
title: Investigation of the Current Disposal Practices data of Unused Medicine among General Public in Achrol Village, Jaipur, Rajasthan (India): A cross-sectional study

description: Lack of knowledge and education is one of the major factors contributing to improper medication waste disposal. We aim to raise awareness of acceptable disposal procedures and minimize detrimental consequences on the ecosystem and community by collecting information on how to properly dispose of a wide variety of household medications. Interviews were conducted utilising a standardised questionnaire developed for a prior research to acquire the necessary data. There were two parts to the questionnaire: basic demographic information (age, gender, education level, and profession) and questions about medication storage and disposal (e.g., whether or not they kept unused medications at home, where they got them, what kind of drugs they were, why they weren't used if they checked the expiration date, and so on). If participants were 18 or older, they were eligible for inclusion. Three methods were used to gather information: a self-made survey, a Google form, and in-person chats. The questionnaire was reviewed by expert. The investigator conducted residence to residence self-structured interview. For a single residence, this amounted to an average of 15 minutes. As a result of their talk, the researcher had all the information they needed to properly complete the subject's questionnaire and data collecting form. The medicine use, storage, and disposal habits of family members, as well as questions on the prevalence of chronic disease, are all included in the questionnaire. Forms for collecting information are applied to document specifics about the remaining or expired medication. The proper use, storage, and disposal of medications were condensed into a brochure and disseminated to the public. Numbers and percentages were used to show the questionnaire data. We utilised descriptive statistics to classify the variables. The study was carried out with the assistance of Microsoft Excel and SPSS version 18. Among the 250 people who filled out the survey, the majority were men (n = 189, 75.6%) and women (n = 61, 24.4%), and the majority were also between the ages of 18 and 25 (n = 208, 83.2%). They have a literacy rate of above 98% (n = 247). Among those who participated in the survey, 71.6% (n = 179) were found to have at least one drug that was not being utilised. The majority of responders (n = 127, 50.8%) reported keeping unneeded medications until they had passed their expiration dates. Almost two thirds (n = 160, 64%) of the homes had suitable storage for their medications, consisting of either containers or shelves. The remainder of them lacked any kind of logical system for storing things. The vast majority of those polled (n = 209, or 83.6%) agreed that proper medication disposal is important. The majority of people surveyed in this research (n=213, 85.2%) agreed that more education is needed to raise awareness about the risks associated with inappropriate medication disposal and the best optimal way to do so.
DOI: 10.17632/5t6r2mvt9j.1
title: Deciphering 3’ UTR mediated gene regulation using interpretable deep representation learning

description: Source code, documentation, and instruction for 3UTRBERT.
DOI: 10.17632/84drsc6gdx.1
title: 2024 supplementary material 2

description: Supplementary Table 2. Differentially expressed genes between UC and control samples in GSE73661.
DOI: 10.17632/kps4psh9z8.1
title: Industrial Policy and Export Product Upgrading Potentiality: A Study Based on the Chinese Government-Approved Project Dataset

description: We constructed a new Chinese industrial policy measure at the product level based on 96,778 government-approved from 2009 to 2017. We classify the products into 3-digit codes according to the Standard International Trade Classification Revision 3 (SITC Rev.3). The aggregate amount of government-approved projects on a specific product measures policy intensity. Our findings reveal that Chinese industrial policy can generally enhance EPUP.
DOI: 10.17632/37m9hr7mzc.1
title: 2024 supplementary material

description: Supplementary Figure 1. Expression of hub genes in the UC and control groups of blood samples GSE94648.
DOI: 10.17632/fyx47c3nx3.1
title: Data of Urban development patterns and Vegetation trends of Tokyo Metropolitan Area

description: This data is for the categories of 9 Urban development patterns over 25-year and 5 Vegetation trends over 37-year in the Tokyo Metropolitan Area. To understand how and why the green spaces change in metropolises under accelerating global urbanization, we propose the Normalized Difference Index (NDI) to intuitively quantify and compare the degree of change over a long-time series in built-up areas, population density, and vegetation cover.
DOI: 10.17632/6h8t8m6f9c.1
title: 2024 supplementary material 1

description: Supplementary Table 1. Four hundred seventy-nine genes downloaded from FerrDb.
DOI: 10.17632/8c8h2ny54v.1
title: Database - Included Clinical studies of Medicinal Cannabis

description: Supplementary figures and tables, and database of included studies.
DOI: 10.17632/29mbb556dp.2
title: Trait Anxiety, Emotion Regulation Strategies, and Metacognitive Beliefs: Their Influence on Executive Functions and Academic Achievement

description: These data are compiled in an Excel spreadsheet from questionnaires completed on LimeSurvey (University Lyon 2). The online questionnaire was distributed between June 2022 and January 2023 primarily through social media platforms. Participants were voluntary, and the data collected were anonymous. 
The supplementary material is also available.
DOI: 10.17632/29mbb556dp.3
title: Correlational Study in French Adolescents

description: Data and Jasp files : correlational study in French adolescents.
DOI: 10.17632/29mbb556dp.1
title: Trait anxiety MCQ CERQ ado

description: These data are compiled in an Excel spreadsheet from questionnaires completed on LimeSurvey (University Lyon 2). The online questionnaire was distributed between June 2022 and January 2023 primarily through social media platforms. Participants were voluntary, and the data collected were anonymous.
DOI: 10.17632/29mbb556dp.4
title: Correlational Study in French Adolescents

description: Data and Jasp files : correlational study in French adolescents.
DOI: 10.17632/2h5j8p9vzh.1
title: Conjunto de dados “Repercussões da covid-19 na capacidade funcional de idosos: estudo longitudinal”

description: Longitudinal study characterized by two evaluations with an interval of 18 months, involving 128 participants aged ≥ 60 years.
DOI: 10.17632/2fmtcfwfv4.1
title: Raw images (Leuzzi et al, Cell, 2024)

description: Raw images of western blots and immunofluorescence experiments (Leuzzi et al, Cell, 2024)
DOI: 10.17632/hvyhkng5jd.1
title: Cutaneous Rosai-Dorfman disease: a systematic review and reappraisal of its treatment and prognosis.

description: Cutaneous Rosai Dorfman disease (CRDD) is a rare histiocytic disorder that shows distinctive clinical presentation and prognosis. Sufficient data is currently lacking regarding evidence-based management of CRDD. This systematic review aims to provide a comprehensive overview of CRDD, focusing on treatment approaches and outcomes. PubMed and Scopus databases were searched for studies on CRDD from June 1st, 2013 to May 31st, 2023. Articles describing cases of CRDD confirmed with histological examination were eligible for inclusion. All interventions for CRDD were analyzed. The primary outcome measure was the response of cutaneous lesions to treatment including complete response, partial response , and no response. The secondary outcome measures were mortality rate, relapse rate, and the occurrence of adverse events related to CRDD treatment. Eighty-seven articles describing 118 CRDD cases were eligible for this review, the following file describes each article and case individually as it was gathered from each paper on an SPSS spreadsheet.
DOI: 10.17632/hvyhkng5jd.2
title: Cutaneous Rosai-Dorfman disease: a systematic review and reappraisal of its treatment and prognosis.

description: Cutaneous Rosai Dorfman disease (CRDD) is a rare histiocytic disorder that shows distinctive clinical presentation and prognosis. Sufficient data is currently lacking regarding evidence-based management of CRDD. This systematic review aims to provide a comprehensive overview of CRDD, focusing on treatment approaches and outcomes. PubMed and Scopus databases were searched for studies on CRDD from June 1st, 2013 to May 31st, 2023. Articles describing cases of CRDD confirmed with histological examination were eligible for inclusion. All interventions for CRDD were analyzed. The primary outcome measure was the response of cutaneous lesions to treatment including complete response, partial response , and no response. The secondary outcome measures were mortality rate, relapse rate, and the occurrence of adverse events related to CRDD treatment. Eighty-seven articles describing 118 CRDD cases were eligible for this review, the following file describes each article and case individually as it was gathered from each paper on an SPSS spreadsheet.
DOI: 10.17632/sys5dd5f3n.1
title: Enumeration and Bacterial Characteristics of Total Aerobic Microorganism in Shumai

description: Results and findings upon studying the characteristics of total aerobic microorganism on Shumai or Shomai (from a public vendor) as sample.
DOI: 10.6084/m9.figshare.24958482.v1
title: Supplementary Material for: Transarterial Chemoembolization Combined with Lenvatinib for Hepatocellular Carcinoma: A Systematic Review and Meta-analysis of Randomized Controlled Trials

description: Introduction: The treatment of hepatocellular carcinoma (HCC) with transarterial chemoembolization (TACE) and lenvatinib individually has shown favorable outcomes, but there is currently no meta-analysis based on randomized controlled trials (RCTs) to investigate the efficacy and safety of this combined treatment for HCC. The aim of this study is to identify the efficacy and safety of TACE plus lenvatinib for the treatment of HCC. 
Methods: A systematic search of MEDLINE (via PubMed), the Cochrane Library, EMBASE, and the Web of Science was conducted on July 31, 2023. RCTs evaluating the efficacy and safety of TACE in combination with lenvatinib for the treatment of HCC were included. The risk of bias in the included studies was assessed using the Risk of Bias 2 tool. Outcome measures such as objective response rate (ORR), CR (complete remission), progression-free survival (PFS), overall survival (OS), and safety parameters were extracted from the included studies. Binary outcomes were analyzed using odds ratio (OR), risk ratio (RR), or hazard ratio (HR), while continuous variables were analyzed using mean difference (MD) or standardized MD (SMD) in Rstudio. The quality of the evidence was graded using the GRADE approach. Heterogeneity was considered significant when the I-squared was 50% or less. 
Results: Five RCTs involving 638 patients were included. The meta-analysis revealed that patients in the TACE plus lenvatinib group had a significantly higher mean ORR compared to the control group (OR: 3.65, 95% CI: 2.50–5.32, fixed effects model; OR: 3.58, 95% CI: 2.45–5.24, random effects model, I2 = 0, moderate quality). Specifically, 40.9% of patients in the TACE plus lenvatinib group achieved a PR, which was significantly higher than the control group (OR: 3.51, 95% CI: 2.41–5.13, fixed effects model; OR: 3.46, 95% CI: 2.36–5.07, random effects model, I2 = 0, moderate quality). The HR for OS was 0.47 (95% CI: 0.35–0.62, fixed effects model and random effects model, I2 = 0, moderate quality). The meta-analysis revealed that the TACE plus lenvatinib group had a significantly higher total adverse effects rate than the control group (OR: 1.86, 95% CI: 1.01–3.43, fixed effects model; OR: 1.85, 95% CI: 1.00–3.43, random effects model, I2 = 0, moderate quality).
Conclusion: Our study suggests that the combination of TACE and lenvatinib in the treatment of HCC has shown promising results, with extended OS and improved ORR.
DOI: 10.6084/m9.figshare.24958482
title: Supplementary Material for: Transarterial Chemoembolization Combined with Lenvatinib for Hepatocellular Carcinoma: A Systematic Review and Meta-analysis of Randomized Controlled Trials

description: Introduction: The treatment of hepatocellular carcinoma (HCC) with transarterial chemoembolization (TACE) and lenvatinib individually has shown favorable outcomes, but there is currently no meta-analysis based on randomized controlled trials (RCTs) to investigate the efficacy and safety of this combined treatment for HCC. The aim of this study is to identify the efficacy and safety of TACE plus lenvatinib for the treatment of HCC. 
Methods: A systematic search of MEDLINE (via PubMed), the Cochrane Library, EMBASE, and the Web of Science was conducted on July 31, 2023. RCTs evaluating the efficacy and safety of TACE in combination with lenvatinib for the treatment of HCC were included. The risk of bias in the included studies was assessed using the Risk of Bias 2 tool. Outcome measures such as objective response rate (ORR), CR (complete remission), progression-free survival (PFS), overall survival (OS), and safety parameters were extracted from the included studies. Binary outcomes were analyzed using odds ratio (OR), risk ratio (RR), or hazard ratio (HR), while continuous variables were analyzed using mean difference (MD) or standardized MD (SMD) in Rstudio. The quality of the evidence was graded using the GRADE approach. Heterogeneity was considered significant when the I-squared was 50% or less. 
Results: Five RCTs involving 638 patients were included. The meta-analysis revealed that patients in the TACE plus lenvatinib group had a significantly higher mean ORR compared to the control group (OR: 3.65, 95% CI: 2.50–5.32, fixed effects model; OR: 3.58, 95% CI: 2.45–5.24, random effects model, I2 = 0, moderate quality). Specifically, 40.9% of patients in the TACE plus lenvatinib group achieved a PR, which was significantly higher than the control group (OR: 3.51, 95% CI: 2.41–5.13, fixed effects model; OR: 3.46, 95% CI: 2.36–5.07, random effects model, I2 = 0, moderate quality). The HR for OS was 0.47 (95% CI: 0.35–0.62, fixed effects model and random effects model, I2 = 0, moderate quality). The meta-analysis revealed that the TACE plus lenvatinib group had a significantly higher total adverse effects rate than the control group (OR: 1.86, 95% CI: 1.01–3.43, fixed effects model; OR: 1.85, 95% CI: 1.00–3.43, random effects model, I2 = 0, moderate quality).
Conclusion: Our study suggests that the combination of TACE and lenvatinib in the treatment of HCC has shown promising results, with extended OS and improved ORR.
DOI: 10.6084/m9.figshare.24958485
title: Supplementary Material for: Transarterial Chemoembolization Combined with Lenvatinib for Hepatocellular Carcinoma: A Systematic Review and Meta-analysis of Randomized Controlled Trials

description: Introduction: The treatment of hepatocellular carcinoma (HCC) with transarterial chemoembolization (TACE) and lenvatinib individually has shown favorable outcomes, but there is currently no meta-analysis based on randomized controlled trials (RCTs) to investigate the efficacy and safety of this combined treatment for HCC. The aim of this study is to identify the efficacy and safety of TACE plus lenvatinib for the treatment of HCC. 
Methods: A systematic search of MEDLINE (via PubMed), the Cochrane Library, EMBASE, and the Web of Science was conducted on July 31, 2023. RCTs evaluating the efficacy and safety of TACE in combination with lenvatinib for the treatment of HCC were included. The risk of bias in the included studies was assessed using the Risk of Bias 2 tool. Outcome measures such as objective response rate (ORR), CR (complete remission), progression-free survival (PFS), overall survival (OS), and safety parameters were extracted from the included studies. Binary outcomes were analyzed using odds ratio (OR), risk ratio (RR), or hazard ratio (HR), while continuous variables were analyzed using mean difference (MD) or standardized MD (SMD) in Rstudio. The quality of the evidence was graded using the GRADE approach. Heterogeneity was considered significant when the I-squared was 50% or less. 
Results: Five RCTs involving 638 patients were included. The meta-analysis revealed that patients in the TACE plus lenvatinib group had a significantly higher mean ORR compared to the control group (OR: 3.65, 95% CI: 2.50–5.32, fixed effects model; OR: 3.58, 95% CI: 2.45–5.24, random effects model, I2 = 0, moderate quality). Specifically, 40.9% of patients in the TACE plus lenvatinib group achieved a PR, which was significantly higher than the control group (OR: 3.51, 95% CI: 2.41–5.13, fixed effects model; OR: 3.46, 95% CI: 2.36–5.07, random effects model, I2 = 0, moderate quality). The HR for OS was 0.47 (95% CI: 0.35–0.62, fixed effects model and random effects model, I2 = 0, moderate quality). The meta-analysis revealed that the TACE plus lenvatinib group had a significantly higher total adverse effects rate than the control group (OR: 1.86, 95% CI: 1.01–3.43, fixed effects model; OR: 1.85, 95% CI: 1.00–3.43, random effects model, I2 = 0, moderate quality).
Conclusion: Our study suggests that the combination of TACE and lenvatinib in the treatment of HCC has shown promising results, with extended OS and improved ORR.