cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.4225/03/5897c6ead6d08
title: Developing and utilizing a mini food powder production facility to produce industrially relevant particles for functionality testing

description: In this thesis is presented research relating to a monodisperse droplet dryer for production of milk powder. The development and testing of several monodisperse droplet generators and lab-scale spray dryers was carried out. Furthermore, a number of down-scaled techniques for quality measurement were devised for analysis of the powder. Sufficient amounts of highly uniform powder could be dried to low moisture contents, using a range of feed solids concentrations and drying air temperatures. A single droplet drying model was created to simulate the situation, based on established mass and heat transfer equations and material specific kinetics using the Reaction Engineering Approach. Through a series of experiments varying drying temperature and feed solids content for a number of feed materials, the model was validated and its limits of accuracy were established. It successfully predicted the true final moisture contents and insolubilities in a range of conditions. The known and uniform temperature history and the regular particle sizes were then used to conduct original research on the formation of insoluble material during powder heat damage and the formation of particle morphology and shrinkage. Work was also done on spray freeze drying, thin layer drying, powder wetting, dissolution and the addition of surfactants.
DOI: 10.4225/03/5897c74849200
title: Studies of low oxidation state group 13 and 14 metallacycles

description: This thesis is mainly concerned with investigations into the reactivity of the gallium(I) N-heterocyclic carbene (NHC) analogue, [K(tmeda)][:Ga{[N(Dip)C(H)]2}] (Dip = C6H3Pri2-2,6).  The preparation of the first monomeric Ge(I) radical was also investigated.  Work carried out in these areas is divided into five chapters.  Chapter 1 provides a general introduction to sub-valent group 13 and 14 chemistry, with an emphasis on the preparation of group 13 metal(I) and group 14 metal(II) N-heterocyclic carbene analogues.  Chapter 2 summarizes investigations into the reactivity of [K(tmeda)] [:Ga{[N(Dip)C(H)]2}] towards groups 2 and 12 metal precursors.  Reactions of magnesium, calcium, strontium, barium, zinc, and cadmium halides with [K(tmeda)][:Ga{[N(Dip)C(H)]2}] are discussed, and the first structurally characterized cadmium-gallium bonded molecular complex is reported.  Chapter 3 summarizes investigations into the reactivity of [K(tmeda)] [:Ga{[N(Dip)C(H)]2}] towards selected lanthanide metal precursors.  Reactions of samarium(II), europium(II), ytterbium(II), thulium(II), and cerium(III) iodides with [K(tmeda)][:Ga{[N(Dip)C(H)]2}] have given rise to a number of novel lanthanide-gallyl species, including the first structurally characterized GaTm or GaSm bonded complexes.  Chapter 4 details the preparation of the first monomeric Ge(I) radical via the reduction of a bulky β-diketiminato germanium(II) precursor.  The verification of the +1 oxidation state in this species was achieved using a combination of crystallographic, EPR and ENDOR spectroscopic, and theoretical analyses. Chapter 5 describes several miscellaneous results, largely derived from attempts to prepare bulky guanidinato complexes of p-block elements in low oxidation states.
DOI: 10.5287/bodleian:mnnpdybpn
title: Ribo-attenuators: novel elements for reliable and modular riboswitch engineering - DATA
DOI: 10.14457/kmitl.the.2002.398
title: ความสัมพันธ์ระหว่างการปฏิบัติทางด้านวินัยของครูในชั้นเรียนกับความรับผิดชอบของนักเรียนในวิทยาลัยเทคนิค เขตกรุงเทพมหานคร /
DOI: 10.14457/kmitl.the.2003.499
title: การบีบอัดข้อมูลภาพ โดยการเข้ารหัสแบบบล็อกหลายขนาด /
DOI: 10.4225/03/5897c47263cfc
title: Epithelial progenitor cells in human endometrium and endometriosis

description: The human endometrium is a highly regenerative tissue that undergoes rapid repair and restoration following menstruation and parturition. Endometrial stem/progenitor cells have been hypothesised to be responsible for this. Despite evidence for endometrial epithelial progenitor cells, there are currently no known markers for their prospective identification. 
The aim of this thesis was to identify a candidate marker by screening endometrial cells against a panel of known and novel antibodies for immunoreactivity by flow cytometry and immunohistochemistry. H3 was identified as a priority and was assessed for its ability to be a candidate marker. Endometrial epithelial cells were flow cytometry sorted into subpopulations based upon the relative expression of H3 and EpCAM (an epithelial marker). These subpopulations were assessed for stem/progenitor cell properties using functional assays. This thesis demonstrates for the first time that H3 and EpCAM are putative markers that enrich for endometrial epithelial progenitor cells that are clonogenic and undergo self-renewal in vitro. 
This thesis also investigated the role that endometrial stem/progenitor cells may have in the development of endometriosis. Shedding endometrium and peritoneal fluid were collected from menstruating women with and without endometriosis and assessed for presence of endometrial stem/progenitor cells. Clonal studies did not support the hypothesis that endometriosis is established because of the erroneous shedding of endometrial stem/progenitor cells during menstruation. This was in contrast to preliminary flow cytometry results that detected an increased expression of putative endometrial stem/progenitor cell markers (H3 and W5C5) in samples collected from endometriosis women. Further studies will investigate this. 
The findings of this thesis have identified a putative marker that will enable further identification of endometrial epithelial progenitor cell markers in future. These markers will allow further characterisation of this rare population and investigations into their potential role in gynaecological disorders such as endometriosis. The current aetiology of endometriosis remains unknown. The identification of endometrial clonogenic cells within endometriotic lesions will provide future examination into what factors in peritoneal fluid may support ectopic endometrial growth so that improvements in treatment can be made.
DOI: 10.4225/03/5897c62b86afc
title: Discovery and optimization of Grb7 antagonists as potential antitumor therapeutics

description: The growth factor receptor bound protein 7 (Grb7) is a non‐catalytic adaptor protein that was originally identified as a binding partner of the growth factor receptor (ErbB‐2). Amplification and overexpression of Grb7 is frequently implicated in the development of aggressive, recalcitrant and advanced tumor phenotypes making it a promising target in human cancers. Apart from several peptide‐based experimental antagonists, to date there exist no potent drug that is developed or known to act against Grb7. Thus, the overall objective of the research conducted in this thesis was to design novel, potent, selective and cell permeable Grb7 antagonists that may have potential as antitumor therapeutics. The first part of the thesis deals with optimization studies around a known lead polypeptide designed to bind to the Grb7 SH2 domain. A total of 11 polypeptides were synthesized with a yield varying from 2 to 17%. The peptide antagonists were found to have moderate binding affinity ranging from 0.6 – 60 μM as determined by isothermal titration calorimetry. Moreover, a short 7 residue cell permeablising sequence was incorporated into the inhibitor peptide construct and its ability to translocate peptides across membranes tested in in vitro and cell based assays. The second part of the thesis focused on small molecule antagonist discovery and optimization. Starting from known peptide leads and an experimental structure of the Grb7 SH2 domain, a series of ligand design techniques comprising shape based similarity searches, molecular docking and 2D‐similarity searching was effected to identify non‐peptide antagonists. In total, three structurally distinct classes of small molecular antagonists with moderate in vitro affinity and in vivo activity were identified from the study. The last part of the project reports the crystal structure determination of two Grb7 SH2 domain constructs. High‐resolution crystal structures of the apo‐ and peptide-bound forms of the Grb7 SH2 domain were determined. All together, extensive biophysical, computational and structural analyses were conducted on the Grb7 SH2 domain and ligands that will form the foundation for future Grb7 inhibitor development.
DOI: 10.4225/03/5897c75938483
title: Distribution and functions of protease inhibitor 8 (SERPINB8)

description: Protease inhibitor 8 (PI8) / SERPINB8 is an intracellular serpin, a member of a class
of protease inhibitors which irreversibly inhibit serine proteases. Other serpins within
clade B are also expressed intracellularly but are not secreted, and are usually found in an
overlapping distribution pattern with their target protease. Some members of this clade have
accepted roles in inhibition of cytotoxic granule proteases. The reactive centre loop (RCL) of
PI8, which directs its specifi city towards a target protease, contains two putative proprotein
convertase recognition sites, suggesting it may play a physiological role in the inhibition of
one or more proprotein convertases.

Furin and other mammalian endopeptidases of the proprotein convertase (PC) family
are noted for their specifi city to the amino acid sequence Arg-X-X-(Lys/Arg). Such cleavage
is a required step for the activation of numerous proteins involved in normal physiological
processes as well as forming the basis of infectivity of viral coat proteins and bacterial
toxins, and progression of tumour growth and arthritis. While the activity of PCs has been
reported to be controlled at the transcription level, there is also evidence that inhibitory
proteins exist which control the action of PCs in vivo. Several members of the serpin family
have reportedly demonstrated in vitro activity against various PCs, most prominently, the
engineered serpin α1-antitrypsin Portland, which has been postulated as a therapeutic agent
(Tsuji et al, 2007). In mammals there is an endogenous serpin, PI8, which demonstrates
rapid inhibition of furin, kinetically characteristic of a physiological inhibitory interaction
(Dahlen et al, 1998).

In this study the murine tissue mRNA distribution of members of the PC family
was correlated with expression of PI8: furin, PC5/6, PACE4 and PC7 showed distribution
overlapping with, but not identical to PI8. PI8 expression was also examined in other organs,
and was found to be predominantly expressed within epithelial cell types. In a mouse model,
mPI8 was shown to be upregulated in the epithelial-mesenchymal transition process in a
model of kidney fi brosis. Further, this study demonstrated that recombinant mouse PI8 is able
to inhibit the activity of several members of the PC family against the fl uorogenic substrate
Boc-RVRR-AMC. Determination of the stoichiometry of inhibition for the interaction
showed PI8 ineffi ciently inhibited PACE4, but is a better inhibitor of PC5/6b, and inhibited
furin approximately at the physiological ratio of 1:1. This result provides support for the role
of PI8 as a physiological inhibitor of furin, and is a novel fi nding of anti-proteolytic activity
by PI8 against PACE4 and PC5/6b, suggesting PI8 may be involved in the physiological
regulation of several prohormone convertases.
DOI: 10.4225/03/5897c83bcea7c
title: Cultural memory and literature: re-imagining Australia’s past

description: This thesis sets out to demonstrate that literature that uses dialogic and syncretic methods to describe a collectively shared experience contributes to cultural memory by recalling the absent and the forgotten and by proposing alternative ways to access and represent the past. I further argue that the intertextual nature and memory work of the texts I evaluate as memorial novels build a complementary and reciprocal relationship with each other and with other texts that respond to Australia’s past to allow for the growth and dispersal of meaning. Understanding how literature contributes to cultural memory has significance for contemporary understandings of Australian culture.
As literature is involved in a continuous looping back to establish and reinforce cultural memory I argue that it takes a particular type of literature to challenge the common opinion and to insert into cultural memory alternative voices and stories, rather than reinforce official culture that insists on fixed or hierarchical forms and adheres to strict boundaries between genres. Following shifts in historical consciousness and theoretical debates about memory in the nineteen-eighties and nineties, there was a corresponding shift in Australian novels that respond to our past, particularly our violent past. The result was a number of what I call memorial novels, novels that articulate the interplay of history, trauma and memory in an effort to move beyond the familiar and the universal, to step outside official history, language and modes of storytelling, and through a process of reimagining the past recognise and expose narrative and linguistic frames of remembrance, and sometimes propose new ways of remembering.
I use Renate Lachmann’s theory of cultural memory and intertextuality to trace the way the mechanisms of forgetting and remembering in literature construct cultural memory and how literature as a memory medium recalls previously silenced knowledge, restores outdated knowledge and reintegrates knowledge that was once considered unofficial, such as oral history and family memories as well as those aspects of the past that had been silenced, forgotten or misunderstood. The narratives are pluralist, ambivalent, heterogeneous and unresolved as narrators and characters re-imagine the past to transgress the traditional boundaries of form and content. Memorial novels rely less on the common polarities of good and evil, left and right, and black and white and recognise that Australian culture has “layers of identity” that can exist in a “pluralist and united world” (Pearson, “White Guilt” 245). History, trauma and memory come together in narratives that use hybrid storytelling modes to re-imagine the past, celebrate survival and offer hope for the future. 
To support my thesis I present a new evaluation of some well known Australian texts and evaluate some more recent texts against my definition of the memorial novel.
DOI: 10.5281/zenodo.268531
title: Sourcerer Asts

description: <strong>Overview</strong>

Sourcerer is a large corpus of open source Java software. It was constructed by fully downloading the source code of 19 K projects, of which 6 K turned out to be empty. And, after performing the following operations:


	Remove non-Java files
	Remove SCM branches
	Remove duplicate projects
	Manually reviewed duplicate files
	Remove test code


The authors have reduced the 390 GB corpus to 14.3 GB. The resulting corpus has been made publicly available.

<strong>Paper Abstract</strong>

Measuring the internal quality of source code is one of the traditional goals of making software development into an engineering discipline. Cyclomatic Complexity (CC) is an often used source code quality metric, next to Source Lines of Code (SLOC). However, the use of the CC metric is challenged by the repeated claim that CC is redundant with respect to SLOC due to strong linear correlation. We test this claim by studying a corpus of 17.8M methods in 13K open-source Java projects. Our results show that direct linear correlation between SLOC and CC is only moderate, as caused by high variance. We observe that aggregating CC and SLOC over larger units of code improves the correlation, which explains reported results of strong linear correlation in literature. We suggest that the primary cause of correlation is the aggregation. Our conclusion is that there is no strong linear correlation between CC and SLOC of Java methods, so we do not conclude that CC is redundant with SLOC. This conclusion contradicts earlier claims from literature, but concurs with the widely accepted practice of measuring of CC next to SLOC.
DOI: 10.5517/ccdc.csd.cc1mjk7y
title: CCDC 1505460: Experimental Crystal Structure Determination

description: Related Article: Nigel Gwini, David M. Marolf, Soo Hun Yoon, Audrey G. Fikes, Amanda C. Dugan, Gregory L. Powell, Vincent M. Lynch, Vladimir N. Nesterov, Gregory T. McCandless|2017|J.Organomet.Chem.|849-850|324|doi:10.1016/j.jorganchem.2017.01.026
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc1mjk8z
title: CCDC 1505461: Experimental Crystal Structure Determination

description: Related Article: Nigel Gwini, David M. Marolf, Soo Hun Yoon, Audrey G. Fikes, Amanda C. Dugan, Gregory L. Powell, Vincent M. Lynch, Vladimir N. Nesterov, Gregory T. McCandless|2017|J.Organomet.Chem.|849-850|324|doi:10.1016/j.jorganchem.2017.01.026
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc1mjkb1
title: CCDC 1505463: Experimental Crystal Structure Determination

description: Related Article: Nigel Gwini, David M. Marolf, Soo Hun Yoon, Audrey G. Fikes, Amanda C. Dugan, Gregory L. Powell, Vincent M. Lynch, Vladimir N. Nesterov, Gregory T. McCandless|2017|J.Organomet.Chem.|849-850|324|doi:10.1016/j.jorganchem.2017.01.026
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.14457/kmitl.res.2013.148
title: ขวดพลาสติกชนิดรีไซเคิลจากขวดนมที่ผลิตจาก HDPE: การเตรียมความสามารถในการขึ้นรูป และสมบัติเชิงกล
DOI: 10.14457/kmitl.the.2002.396
title: เตาเผาแกลบวอร์เทคหลายขั้น /
DOI: 10.14457/kmitl.the.2003.495
title: การรู้จำอักษรตัวพิมพ์ภาษาไทยโดยใช้ฟัซซี่เซ็ตและราฟเซ็ต /
DOI: 10.14457/kmitl.the.2003.496
title: อิทธิพลของชนิดสัตว์เคี้ยวเอื้องและอัตราเจริญเติบโตที่มีต่อคุณภาพซาก /
DOI: 10.14457/kmitl.the.2003.498
title: การเปรียบเทียบวิธีการควบคุมความถี่และการควบคุมจำนวนพัลส์ ในเครื่องหลอมโลหะเหนี่ยวนำความถี่สูง /
DOI: 10.14457/kmitl.the.2003.502
title: การวิเคราะห์คุณลักษณะของสายอากาศไมโครสตริปแบบช่องเปิด โดยวิธี FDTD /
DOI: 10.14457/kmitl.the.2003.516
title: การพัฒนาชุดบำบัดน้ำเสียสำหรับที่พักอาศัย /
DOI: 10.4225/03/58940c4b7a912
title: Studio conditions

description: STUDIO CONDITIONS is a site-driven art project that explores how institutional structures and subjective identities mutually constitute each other. The project involves two types of sites: the artist’s studio in a university art department; and four fieldwork sites––a friend’s lounge-room, parent’s backyard, a student common room and an urban foreshore area. The work explores the roles artists play within the institution of art and academia. These concerns are explored in a material form via the production of sculptural furniture, related sited installations and performances. The artist’s fieldwork draws upon various community frameworks both within its understanding of site and its enactment of collaborative processes. The fieldwork highlights both local social narratives and the project’s institutional boundaries. The artistic activity in each respective site results in a ‘propositional artwork.’ These propositions involve publication of a sited idea rather than an actual sited intervention. As a result, the work is ‘site specific’ but only in the sense that it offers a discursive exploration of the idea of site. 

The exegetic text that accompanies STUDIO CONDITIONS explores the social aspects of the work. It argues that art is always, already, social, as the conditions of its production, exchange, and reception are products of society. The exegesis first contextualises STUDIO CONDITIONS within the tradition of Institutional Critique and draws on Andrea Fraser’s framing of this methodology as ‘critically reflexive site specificity.’ This strategy of interrogating the role of the co-opted artist within the institutional siting of art draws on a range of artistic, social and political considerations. The artwork is interpreted via a range of concerns that include: the historical lineage of identity politics; the psychological dimension of artistic failure within the progress-driven paradigm of the university; the complex community dynamics that surround any site of artistic process or presentation.  Next the exegesis assesses how social relations within art are valued, give value and are evaluated within both heteronomous and autonomous conceptions of art. The discussion of sociability, art, and site includes an examination of Nicolas Bourriaud’s notion of ‘relational aesthetics’ and argues that this reading needs to be supplemented by a richer understanding of the ways in which sociability is embedded in art objects, in processes of production, in audience reception, and is embodied within the formal languages of objects and representation.