DOI: 10.5061/dryad.4rd1g
title: Data from: Neural correlates of individual differences in circadian behavior

description: Daily rhythms in mammals are controlled by the circadian system, which is
 a collection of biological clocks regulated by a central pacemaker within
 the suprachiasmatic nucleus (SCN) of the anterior hypothalamus. Changes in
 SCN function have pronounced consequences for behaviour and physiology;
 however, few studies have examined whether individual differences in
 circadian behaviour reflect changes in SCN function. Here,
 PERIOD2::LUCIFERASE mice were exposed to a behavioural assay to
 characterize individual differences in baseline entrainment, rate of
 re-entrainment and free-running rhythms. SCN slices were then collected
 for ex vivo bioluminescence imaging to gain insight into how the
 properties of the SCN clock influence individual differences in
 behavioural rhythms. First, individual differences in the timing of
 locomotor activity rhythms were positively correlated with the timing of
 SCN rhythms. Second, slower adjustment during simulated jetlag was
 associated with a larger degree of phase heterogeneity among SCN neurons.
 Collectively, these findings highlight the role of the SCN network in
 determining individual differences in circadian behaviour. Furthermore,
 these results reveal novel ways that the network organization of the SCN
 influences plasticity at the behavioural level, and lend insight into
 potential interventions designed to modulate the rate of resynchronization
 during transmeridian travel and shift work..
description: PER2::LUC Imaging
 Mouse#337This file contains a
 tiff sequence for PER2::LUC imagign data from SCN slices collected from
 Mouse#337 (rostral SCN = Slice1, middle SCN = Slice2, caudal SCN =
 Slice3).#337.zipPER2::LUC Imaging Mouse#338This file contains a tiff sequence for PER2::LUC imagign data from SCN slices collected from Mouse#338 (rostral SCN = Slice1, middle SCN = Slice2, caudal SCN = Slice3).#338.zipPER2::LUC Imaging Mouse#340This file contains a tiff sequence for PER2::LUC imagign data from SCN slices collected from Mouse#340 (rostral SCN = Slice1, middle SCN = Slice2, caudal SCN = Slice3).#340.zipPER2::LUC Imaging Mouse#341This file contains a tiff sequence for PER2::LUC imagign data from SCN slices collected from Mouse#341 (rostral SCN = Slice1, middle SCN = Slice2, caudal SCN = Slice3).#341.zipPER2::LUC Imaging Mouse#342This file contains a tiff sequence for PER2::LUC imagign data from SCN slices collected from Mouse#342 (rostral SCN = Slice1, middle SCN = Slice2, caudal SCN = Slice3).#342.zipPER2::LUC Imaging Mouse#344This file contains a tiff sequence for PER2::LUC imagign data from SCN slices collected from Mouse#344 (rostral SCN = Slice1, middle SCN = Slice2, caudal SCN = Slice3).#344.zipPER2::LUC Imaging Mouse#345This file contains a tiff sequence for PER2::LUC imagign data from SCN slices collected from Mouse#345 (rostral SCN = Slice1, middle SCN = Slice2, caudal SCN = Slice3).#345.zipPER2::LUC Imaging Mouse#346This file contains a tiff sequence for PER2::LUC imagign data from SCN slices collected from Mouse#346 (rostral SCN = Slice1, middle SCN = Slice2, caudal SCN = Slice3).#346.zipPER2::LUC Imaging Mouse#349This file contains a tiff sequence for PER2::LUC imagign data from SCN slices collected from Mouse#349 (rostral SCN = Slice1, middle SCN = Slice2, caudal SCN = Slice3).#349.zipPER2::LUC Imaging Mouse#353This file contains a tiff sequence for PER2::LUC imagign data from SCN slices collected from Mouse#353 (rostral SCN = Slice1, middle SCN = Slice2, caudal SCN = Slice3).#353.zipPER2::LUC Imaging Mouse#360This file contains a tiff sequence for PER2::LUC imagign data from SCN slices collected from Mouse#360 (rostral SCN = Slice1, middle SCN = Slice2, caudal SCN = Slice3).#360.zipPER2::LUC Imaging Mouse#362This file contains a tiff sequence for PER2::LUC imagign data from SCN slices collected from Mouse#362 (rostral SCN = Slice1, middle SCN = Slice2, caudal SCN = Slice3).#362.zipPER2::LUC Imaging Mouse#363This file contains a tiff sequence for PER2::LUC imagign data from SCN slices collected from Mouse#363 (rostral SCN = Slice1, middle SCN = Slice2, caudal SCN = Slice3).#363.zipPER2::LUC Imaging Mouse#372This file contains a tiff sequence for PER2::LUC imagign data from SCN slices collected from Mouse#372 (rostral SCN = Slice1, middle SCN = Slice2, caudal SCN = Slice3).#372.zipPER2::LUC Imaging Mouse#373This file contains a tiff sequence for PER2::LUC imagign data from SCN slices collected from Mouse#373 (rostral SCN = Slice1, middle SCN = Slice2, caudal SCN = Slice3).#373.zipPER2::LUC Imaging Mouse#374This file contains a tiff sequence for PER2::LUC imagign data from SCN slices collected from Mouse#374 (rostral SCN = Slice1, middle SCN = Slice2, caudal SCN = Slice3).#374.zipPER2::LUC Imaging Mouse#375This file contains a tiff sequence for PER2::LUC imagign data from SCN slices collected from Mouse#375 (rostral SCN = Slice1, middle SCN = Slice2, caudal SCN = Slice3).#375.zipPER2::LUC Imaging Mouse#376This file contains a tiff sequence for PER2::LUC imagign data from SCN slices collected from Mouse#376 (rostral SCN = Slice1, middle SCN = Slice2, caudal SCN = Slice3).#376.zipPER2::LUC Imaging Mouse#377This file contains a tiff sequence for PER2::LUC imagign data from SCN slices collected from Mouse#377 (rostral SCN = Slice1, middle SCN = Slice2, caudal SCN = Slice3).#377.zipPER2::LUC Imaging Mouse#379This file contains a tiff sequence for PER2::LUC imagign data from SCN slices collected from Mouse#379 (rostral SCN = Slice1, middle SCN = Slice2, caudal SCN = Slice3).#379.zipPER2::LUC Imaging Mouse#380This file contains a tiff sequence for PER2::LUC imagign data from SCN slices collected from Mouse#380 (rostral SCN = Slice1, middle SCN = Slice2, caudal SCN = Slice3).#380.zipPER2::LUC Imaging Mouse#383This file contains a tiff sequence for PER2::LUC imagign data from SCN slices collected from Mouse#383 (rostral SCN = Slice1, middle SCN = Slice2, caudal SCN = Slice3).#383.zipPER2::LUC Imaging Mouse#384This file contains a tiff sequence for PER2::LUC imagign data from SCN slices collected from Mouse#384 (rostral SCN = Slice1, middle SCN = Slice2, caudal SCN = Slice3).#384.zipBehavioral Data - ActogramsThis file contains activity records for the in vivo phenotyping phase of this study. To view, it is best to open them with Clocklab software.