cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.11805903.v1
title: A food-responsive switch modulates TFEB and autophagy, and determines susceptibility to coxsackievirus infection and pancreatitis

description: Almost a billion people worldwide are chronically undernourished. Herein, using a mouse model of coxsackievirus B3 (CVB3) infection, we report that a single day of food restriction (FR) markedly increases susceptibility to attenuated enterovirus infection, replication, and disease. These “pro-viral” effects, which are rapidly-reversed by the restoration of food, are mediated by several genes whose expression is altered by FR, and which support CVB3 replication. Central to this is TFEB, a protein whose expression and activation status are rapidly increased by FR. TFEB, which regulates the transcription of &gt;100 genes involved in macroautophagy/autophagy and lysosomal biogenesis, responds similarly to both FR and CVB3 infection and plays a pivotal role in determining host susceptibility to CVB3. We propose that, by upregulating TFEB, FR generates an intracellular environment that is more hospitable to the incoming virus, facilitating its replication. This interplay between nutritional status and enterovirus replication has implications for human health and, perhaps, for the evolution of these viruses. <b>Abbreviations:</b> Atg/ATG: autophagy-related; CAR: Coxsackievirus and adenovirus receptor; Cas9: CRISPR associated protein 9; Cre: recombinase that causes recombination; CRISPR: clustered regularly interspaced short palindromic repeats; <i>Ctsb</i>/CTSB: cathepsin B; CVB3: coxsackievirus B3; DsRedCVB3: a recombinant CVB3 that encodes the Discosoma red fluorescent protein; EL: elastase; FR: food restriction; GFP: green fluorescent protein; gRNA: guide RNA; HBSS: Hanks Buffered Salt Solution; LYNUS: lysosomal nutrient sensing machinery; MAP1LC3/LC3: microtubule-associated protein 1 light chain 3; MFI: mean fluorescence intensity; MOI: multiplicity of infection; MTOR: mechanistic target of rapamycin kinase; Nluc: nanoluciferase; NlucCVB3: a recombinant CVB3 encoding nanoluciferase; pfu: plaque-forming unit(s); p.i.: post infection; rCVB: recombinant coxsackievirus B3; RPS6KB/p70S6K: ribosomal protein S6 kinase; RT: room temperature; siRNA: small interfering RNA; TFEB: transcription factor EB; tg: transgenic; TUBB: β-tubulin; UNINF: uninfected; wrt: with respect to; WT: wild type.
DOI: 10.6084/m9.figshare.11805903
title: A food-responsive switch modulates TFEB and autophagy, and determines susceptibility to coxsackievirus infection and pancreatitis

description: Almost a billion people worldwide are chronically undernourished. Herein, using a mouse model of coxsackievirus B3 (CVB3) infection, we report that a single day of food restriction (FR) markedly increases susceptibility to attenuated enterovirus infection, replication, and disease. These “pro-viral” effects, which are rapidly-reversed by the restoration of food, are mediated by several genes whose expression is altered by FR, and which support CVB3 replication. Central to this is TFEB, a protein whose expression and activation status are rapidly increased by FR. TFEB, which regulates the transcription of &gt;100 genes involved in macroautophagy/autophagy and lysosomal biogenesis, responds similarly to both FR and CVB3 infection and plays a pivotal role in determining host susceptibility to CVB3. We propose that, by upregulating TFEB, FR generates an intracellular environment that is more hospitable to the incoming virus, facilitating its replication. This interplay between nutritional status and enterovirus replication has implications for human health and, perhaps, for the evolution of these viruses. <b>Abbreviations:</b> Atg/ATG: autophagy-related; CAR: Coxsackievirus and adenovirus receptor; Cas9: CRISPR associated protein 9; Cre: recombinase that causes recombination; CRISPR: clustered regularly interspaced short palindromic repeats; <i>Ctsb</i>/CTSB: cathepsin B; CVB3: coxsackievirus B3; DsRedCVB3: a recombinant CVB3 that encodes the Discosoma red fluorescent protein; EL: elastase; FR: food restriction; GFP: green fluorescent protein; gRNA: guide RNA; HBSS: Hanks Buffered Salt Solution; LYNUS: lysosomal nutrient sensing machinery; MAP1LC3/LC3: microtubule-associated protein 1 light chain 3; MFI: mean fluorescence intensity; MOI: multiplicity of infection; MTOR: mechanistic target of rapamycin kinase; Nluc: nanoluciferase; NlucCVB3: a recombinant CVB3 encoding nanoluciferase; pfu: plaque-forming unit(s); p.i.: post infection; rCVB: recombinant coxsackievirus B3; RPS6KB/p70S6K: ribosomal protein S6 kinase; RT: room temperature; siRNA: small interfering RNA; TFEB: transcription factor EB; tg: transgenic; TUBB: β-tubulin; UNINF: uninfected; wrt: with respect to; WT: wild type.
DOI: 10.6084/m9.figshare.11880732
title: Trehalose limits opportunistic mycobacterial survival during HIV co-infection by reversing HIV-mediated autophagy block

description: Opportunistic bacterial infections amongst HIV–infected individuals contribute significantly to HIV-associated mortality. The role of HIV-mediated modulation of innate mechanisms like autophagy in promoting opportunistic infections, however, remains obscure. Here we show, HIV reactivation in or infection of macrophages inhibits autophagy and helps the survival of pathogenic <i>Mycobacterium tuberculosis (Mtb)</i> and nonpathogenic non-tuberculous mycobacterial strains (NTMs). The HIV-mediated impairment of xenophagy flux facilitated bacterial survival. Activation of autophagy by trehalose could induce xenophagy flux and kill intracellular <i>Mtb</i> or NTMs either during single or co-infections. Trehalose, we delineate, activates PIKFYVE leading to TFEB nuclear translocation in MCOLN1-dependent manner to induce autophagy. Remarkably, trehalose significantly reduced HIV-p24 levels in <i>ex–vivo</i>-infected PBMCs or PBMCs from treatment-naive HIV patients and also controlled mycobacterial survival within <i>Mtb</i>-infected animals. To conclude, we report leveraging of HIV-mediated perturbed host innate-immunity by opportunistic bacterial pathogens and show an attractive therapeutic strategy for HIV and associated co-morbidities. <b>Abbreviations:</b> AIDS: acquired immune deficiency syndrome; AMPK: AMP-activated protein kinase; ATG5: autophagy related 5; BafA1: bafilomycin A<sub>1</sub>; CFU: colony forming unit; CTSD: cathepsin D; CD63: CD63 molecule; EGFP: enhanced green fluorescent protein; FRET: Förster resonance energy transfer; GABARAP: gamma-aminobutyric acid receptor-associated protein; GAPDH: glyceraldehyde 3-phosphate dehydrogenase; GLUT: glucose transporter; HIV: human immunodeficiency virus; hMDMs: human monocyte derived macrophages; IL2: interleukin 2; LAMP1: lysosomal-associated membrane protein 1; LC3B-II: lipidated microtubule-associated proteins 1A/1B light chain 3B; Mtb: <i>Mycobacterium tuberculosis</i>; MTOR: mechanistic target of rapamycin; mRFP: monomeric red fluorescent protein; M6PR: mannose-6-phosphate receptor; NAC: N- acetyl- L –cysteine; NTM’s: non-tuberculous mycobacteria; PBMC: Peripheral Blood Mononuclear cells; PIKFYVE: phosphoinositide kinase; FYVE-Type Zinc Finger; PHA: phytohemagglutinin; PMA: phorbol 12-myristate 13-acetate; PtdIns(3,5)P2: Phosphatidylinositol 3,5-bisphosphate; <i>ptfLC3: pEGFP-mRFP-LC3</i>; ROS: reactive oxygen species; SQSTM1: sequestosome1; TFEB: transcription factor EB; MCOLN1/TRPML1: mucolipin 1; PIP4P1/TMEM55B: Human trans-membrane Protein 55B; UVRAG: UV Radiation Resistance Associate; VPS35: vacuolar protein sorting associated protein 35; WDR45: WD repeat domain 45; YCAM: Yellow Chameleon.
DOI: 10.21227/vk3w-q805
title: January 28 submission

description: ---
DOI: 10.6073/pasta/2ce40885c7c586dc56386381d1a61377
title: Microclimate at Harvard Forest HEM, LPH and EMS Towers since 2005

description: Microclimatic data are collected continuously within footprint areas of the flux towers in order to (1) understand relationships between climatic and microclimatic conditions and carbon dioxide and water vapor exchange between forest and atmosphere, (2) to develop predictive models for the exchange rates of these gases, based on microclimate data, (3) detect long-term trends in climate and microclimate at the sites and (4) determine whether the response of carbon dioxide and water vapor exchange processes to climate or microclimate is changing over time. The primary climatic and microclimatic variables measured at these sites include: above-canopy photosynthetically active radiation (PAR), forest understory PAR at 1 m height, total net radiation exchange measured above the forest canopy, air temperature and relative humidity above the forest canopy, forest understory air temperature at 20 cm and 1 m above ground level (shielded but not ventilated thermocouple sensors, used only to estimate nighttime understory air temperature), soil temperature at 10 cm depth, and soil moisture.
DOI: 10.5517/ccdc.csd.cc1ls61m
title: CCDC 1483010: Experimental Crystal Structure Determination

description: Related Article: Pedro Valerga, M.Carmen Puerta, Manuel Jiménez-Tenorio|2016|CSD Communication|||
description: Related Article: José Manuel Botubol-Ares, Safa Cordón-Ouahhabi, Zakaria Moutaoukil, Isidro G. Collado, Manuel Jiménez-Tenorio, M. Carmen Puerta, Pedro Valerga|2021|Organometallics|40|792|doi:10.1021/acs.organomet.1c00045
DOI: 10.5517/ccdc.csd.cc20qlbp
title: CCDC 1868752: Experimental Crystal Structure Determination

description: Related Article: Patryk Tomaszewski, Marcin Wiszniewski, Janusz Serwatowski, Krzysztof Woźniak, Krzysztof Durka, Sergiusz Luliński|2018|Dalton Trans.|47|16627|doi:10.1039/C8DT04068K
DOI: 10.5517/ccdc.csd.cc21r8jm
title: CCDC 1899200: Experimental Crystal Structure Determination

description: Related Article: Deepak Bansal, Pritam Mukhopadhyay|2021|J.Mater.Chem.C|9|3948|doi:10.1039/D0TC05702A
DOI: 10.5517/ccdc.csd.cc224y06
title: CCDC 1911367: Experimental Crystal Structure Determination

description: Related Article: Hai-Xia Yu, Junge Zhi, Jin-Liang Wang|2021|J.Mater.Chem.C|9|3882|doi:10.1039/D0TC05994C
DOI: 10.5517/ccdc.csd.cc224y17
title: CCDC 1911368: Experimental Crystal Structure Determination

description: Related Article: Hai-Xia Yu, Junge Zhi, Jin-Liang Wang|2021|J.Mater.Chem.C|9|3882|doi:10.1039/D0TC05994C
DOI: 10.5517/ccdc.csd.cc224y28
title: CCDC 1911369: Experimental Crystal Structure Determination

description: Related Article: Hai-Xia Yu, Junge Zhi, Jin-Liang Wang|2021|J.Mater.Chem.C|9|3882|doi:10.1039/D0TC05994C
DOI: 10.5517/ccdc.csd.cc3cpw0
title: CCDC 100622: Experimental Crystal Structure Determination

description: Related Article: K. Biradha, K.N. Power, N.S. White, C.Seward, M.J. Zaworotko|2019|CSD Communication|||
DOI: 10.5517/ccdc.csd.cc3wlzj
title: CCDC 115908: Experimental Crystal Structure Determination

description: Related Article: K. Biradha, K.N. Power, N.S. White, C. Seward, M.J. Zaworotko|2019|CSD Communication|||
DOI: 10.5517/ccdc.csd.cc24h8hf
title: CCDC 1980884: Experimental Crystal Structure Determination

description: Related Article: Sikun Zhang, Xiaodong Yang, Xu Liu, Letian Xu, Bin Rao, Ni Yan, Gang He|2021|J.Mater.Chem.C|9|4053|doi:10.1039/D0TC05640E
DOI: 10.5517/ccdc.csd.cc24h8jg
title: CCDC 1980885: Experimental Crystal Structure Determination

description: Related Article: Sikun Zhang, Xiaodong Yang, Xu Liu, Letian Xu, Bin Rao, Ni Yan, Gang He|2021|J.Mater.Chem.C|9|4053|doi:10.1039/D0TC05640E
DOI: 10.5517/ccdc.csd.cc24sk4n
title: CCDC 1989801: Experimental Crystal Structure Determination

description: Related Article: Pavel Arsenyan, Brigita Vigante, Karolis Leitonas, Dmytro Volyniuk, Viktorija Andruleviciene, Levani Skhirtladze, Sergey Belyakov, Juozas Vidas Grazulevicius|2021|J.Mater.Chem.C|9|3928|doi:10.1039/D0TC05745B
DOI: 10.5517/ccdc.csd.cc24sk6q
title: CCDC 1989803: Experimental Crystal Structure Determination

description: Related Article: Pavel Arsenyan, Brigita Vigante, Karolis Leitonas, Dmytro Volyniuk, Viktorija Andruleviciene, Levani Skhirtladze, Sergey Belyakov, Juozas Vidas Grazulevicius|2021|J.Mater.Chem.C|9|3928|doi:10.1039/D0TC05745B
DOI: 10.5517/ccdc.csd.cc24smrb
title: CCDC 1989882: Experimental Crystal Structure Determination

description: Related Article: Sikun Zhang, Xiaodong Yang, Xu Liu, Letian Xu, Bin Rao, Ni Yan, Gang He|2021|J.Mater.Chem.C|9|4053|doi:10.1039/D0TC05640E
DOI: 10.17870/bathspa.10110818
title: Elbow - 300-Word Statement

description: In August 2015 the C&C Gallery hosted an innovative residency program, <i>Elbow</i>, which transformed the public gallery into a dynamic studio environment to facilitate the production of artworks in response to ideas surrounding the condition of blindness and alternative ways of seeing. Through collaborative making and interdisciplinary workshops, the programme investigated ways of guiding, seeing, doing, and making, and explored how digital technology might change our ‘vision’ and understanding of forms.This item contains a 300-word statement about the research project.<br><br>
DOI: 10.17870/bathspa.10110818.v1
title: Elbow - 300-Word Statement

description: In August 2015 the C&C Gallery hosted an innovative residency program, <i>Elbow</i>, which transformed the public gallery into a dynamic studio environment to facilitate the production of artworks in response to ideas surrounding the condition of blindness and alternative ways of seeing. Through collaborative making and interdisciplinary workshops, the programme investigated ways of guiding, seeing, doing, and making, and explored how digital technology might change our ‘vision’ and understanding of forms.This item contains a 300-word statement about the research project.<br><br>
DOI: 10.17870/bathspa.9912962
title: Elbow - Research Timeline and Research Questions

description: In August 2015 the C&C Gallery hosted an innovative residency program, <i>Elbow</i>, which transformed the public gallery into a dynamic studio environment to facilitate the production of artworks in response to ideas surrounding the condition of blindness and alternative ways of seeing. Through collaborative making and interdisciplinary workshops, the programme investigated ways of guiding, seeing, doing, and making, and explored how digital technology might change our ‘vision’ and understanding of forms.This item contains the Research Timeline for the project and a set of Research Questions. <br><br>
DOI: 10.17870/bathspa.9912779
title: Elbow - Exhibition, London, 2015

description: In August 2015 the C&C Gallery hosted an innovative residency program, <i>Elbow</i>, which transformed the public gallery into a dynamic studio environment to facilitate the production of artworks in response to ideas surrounding the condition of blindness and alternative ways of seeing. Through collaborative making and interdisciplinary workshops, the programme investigated ways of guiding, seeing, doing, and making, and explored how digital technology might change our ‘vision’ and understanding of forms.This item contains photographs of the <i>Elbow </i>exhibition (5 September - 4 October 2015, C&C Gallery, London), as well as a digital artwork by Michael J Colegate that was created in response to <i>Elbow </i>artists and also exhibited at the show.Contributors to the exhibition included: Jenny Dunseath, Ian Dawson, Claude Heath, Louisa Minkin, Nicola Thomas, John Greenwood, Mhairi Vari, Michael Colegate, Dr Andrew Jones, and Dr Marta Diaz-Guardamino.Images courtesy of C&C Gallery and Ian Dawson. Used with permission.Video artwork by MJ Colegate. Used with permission.<br><br> <br>
DOI: 10.17870/bathspa.9912779.v1
title: Elbow - Exhibition, London, 2015

description: In August 2015 the C&C Gallery hosted an innovative residency program, <i>Elbow</i>, which transformed the public gallery into a dynamic studio environment to facilitate the production of artworks in response to ideas surrounding the condition of blindness and alternative ways of seeing. Through collaborative making and interdisciplinary workshops, the programme investigated ways of guiding, seeing, doing, and making, and explored how digital technology might change our ‘vision’ and understanding of forms.This item contains photographs of the <i>Elbow </i>exhibition (5 September - 4 October 2015, C&C Gallery, London), as well as a digital artwork by Michael J Colegate that was created in response to <i>Elbow </i>artists and also exhibited at the show.Contributors to the exhibition included: Jenny Dunseath, Ian Dawson, Claude Heath, Louisa Minkin, Nicola Thomas, John Greenwood, Mhairi Vari, Michael Colegate, Dr Andrew Jones, and Dr Marta Diaz-Guardamino.Images courtesy of C&C Gallery and Ian Dawson. Used with permission.Video artwork by MJ Colegate. Used with permission.<br><br> <br>
DOI: 10.17870/bathspa.6865406
title: Elbow - Methodology, Residency Photographs and Narrative

description: In August 2015 the C&C Gallery hosted an innovative residency program, <i>Elbow</i>, which transformed the public gallery into a dynamic studio environment to facilitate the production of artworks in response to ideas surrounding the condition of blindness and alternative ways of seeing. Through collaborative making and interdisciplinary workshops, the programme investigated ways of guiding, seeing, doing, and making, and explored how digital technology might change our ‘vision’ and understanding of forms.This item includes Dunseath's project narrative and methodology, as well as photographic documentation of the <i>Elbow</i> residency and an accompanying image narrative.Images used courtesy of C&C Gallery, Jenny Dunseath, Ian Dawson, and Louisa Minkin.<br>
DOI: 10.17870/bathspa.6865406.v1
title: Elbow - Methodology, Residency Photographs and Narrative

description: In August 2015 the C&C Gallery hosted an innovative residency program, <i>Elbow</i>, which transformed the public gallery into a dynamic studio environment to facilitate the production of artworks in response to ideas surrounding the condition of blindness and alternative ways of seeing. Through collaborative making and interdisciplinary workshops, the programme investigated ways of guiding, seeing, doing, and making, and explored how digital technology might change our ‘vision’ and understanding of forms.This item includes Dunseath's project narrative and methodology, as well as photographic documentation of the <i>Elbow</i> residency and an accompanying image narrative.Images used courtesy of C&C Gallery, Jenny Dunseath, Ian Dawson, and Louisa Minkin.<br>
DOI: 10.17870/bathspa.12556082
title: Elbow - Talks and Workshops

description: In August 2015 the C&C Gallery hosted an innovative residency program, <i>Elbow</i>, which transformed the public gallery into a dynamic studio environment to facilitate the production of artworks in response to ideas surrounding the condition of blindness and alternative ways of seeing. Through collaborative making and interdisciplinary workshops, the programme investigated ways of guiding, seeing, doing, and making, and explored how digital technology might change our ‘vision’ and understanding of forms.<br>This item contains information about the talks and workshops that took place during the residency, including a talk and workshop with John Dickinson-Lilley and a workshop with Ian Dawson. The talk by John Dickinson-Lilley can be accessed in full here. For related links see 'References' below.<br>C&C Gallery website screenshots used with permission of Dr Joanna Gore and Emily Gore (http://www.ccgallery.co.uk/).<br><b>The work is under copyright and may not be used without permission. Use of this repository acknowledges cooperation with its policies and relevant copyright law.</b><br>
DOI: 10.17870/bathspa.12556082.v1
title: Elbow - Talks and Workshops

description: In August 2015 the C&C Gallery hosted an innovative residency program, <i>Elbow</i>, which transformed the public gallery into a dynamic studio environment to facilitate the production of artworks in response to ideas surrounding the condition of blindness and alternative ways of seeing. Through collaborative making and interdisciplinary workshops, the programme investigated ways of guiding, seeing, doing, and making, and explored how digital technology might change our ‘vision’ and understanding of forms.<br>This item contains information about the talks and workshops that took place during the residency, including a talk and workshop with John Dickinson-Lilley and a workshop with Ian Dawson. The talk by John Dickinson-Lilley can be accessed in full here. For related links see 'References' below.<br>C&C Gallery website screenshots used with permission of Dr Joanna Gore and Emily Gore (http://www.ccgallery.co.uk/).<br><b>The work is under copyright and may not be used without permission. Use of this repository acknowledges cooperation with its policies and relevant copyright law.</b><br>
DOI: 10.17870/bathspa.9912977
title: Elbow - Website, Blog, Exhibition Press Release and Call for Artists

description: In August 2015 the C&C Gallery hosted an innovative residency program, <i>Elbow</i>, which transformed the public gallery into a dynamic studio environment to facilitate the production of artworks in response to ideas surrounding the condition of blindness and alternative ways of seeing. Through collaborative making and interdisciplinary workshops, the programme investigated ways of guiding, seeing, doing, and making, and explored how digital technology might change our ‘vision’ and understanding of forms.This item contains a link to the C&C Gallery Residency Blog and a brief video showing user interaction with the Blog. It also contains links to the C&C Gallery web pages for the <i>Elbow</i> residency, the gallery's call for artists, and a press release for the exhibition. For links see 'References' below.Elbow blog video capture used with permission of Dr Joanna Gore and Emily Gore (http://www.ccgallery.co.uk/).<br><b>The work is under copyright and may not be used without permission. Use of this repository acknowledges cooperation with its policies and relevant copyright law.</b><br>
DOI: 10.17870/bathspa.9912977.v1
title: Elbow - Website, Blog, Exhibition Press Release and Call for Artists

description: In August 2015 the C&C Gallery hosted an innovative residency program, <i>Elbow</i>, which transformed the public gallery into a dynamic studio environment to facilitate the production of artworks in response to ideas surrounding the condition of blindness and alternative ways of seeing. Through collaborative making and interdisciplinary workshops, the programme investigated ways of guiding, seeing, doing, and making, and explored how digital technology might change our ‘vision’ and understanding of forms.This item contains a link to the C&C Gallery Residency Blog and a brief video showing user interaction with the Blog. It also contains links to the C&C Gallery web pages for the <i>Elbow</i> residency, the gallery's call for artists, and a press release for the exhibition. For links see 'References' below.Elbow blog video capture used with permission of Dr Joanna Gore and Emily Gore (http://www.ccgallery.co.uk/).<br><b>The work is under copyright and may not be used without permission. Use of this repository acknowledges cooperation with its policies and relevant copyright law.</b><br>