cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.15468/dl.q57872
title: Occurrence Download

description: A dataset containing 6 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Geometry POLYGON((-71.55944824218751 -10.452289581298828,-70.90026855468751 -10.452289581298828,-70.90026855468751 -9.793109893798828,-71.55944824218751 -9.793109893798828,-71.55944824218751 -10.452289581298828))",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 "TaxonKey is Dinomys branickii Peters, 1873"
 ]
}

 The dataset includes 6 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0076343-210914110416597/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.fvcv3e
title: Occurrence Download

description: A dataset containing 4701 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Velloziaceae",
 "HasCoordinate is true",
 "HasGeospatialIssue is false"
 ]
}

 The dataset includes 4701 records from 102 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0010860-160118175350007/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.sks7vu
title: Occurrence Download

description: A dataset containing 18 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Corydalis dubia Prain"
 ]
}

 The dataset includes 18 records from 9 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0010198-240314170635999/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.4wkd6u
title: Occurrence Download

description: A dataset containing 1 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Geometry POLYGON((-75.03463457816588 -14.166645455667808,-71.03463457816588 -14.166645455667808,-71.03463457816588 -10.166645455667808,-75.03463457816588 -10.166645455667808,-75.03463457816588 -14.166645455667808))",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 "TaxonKey is Dendrophidion dendrophis (Schlegel, 1837)"
 ]
}

 The dataset includes 1 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0037170-210914110416597/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.dguwzk
title: Occurrence Download

description: A dataset containing 2605 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Chiroptera",
 "Country is Malawi"
 ]
}

 The dataset includes 2605 records from 16 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0010860-170714134226665/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.3ckehb
title: Occurrence Download

description: A dataset containing 450 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Crassula globularioides Britten"
 ]
}

 The dataset includes 450 records from 31 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0010176-240314170635999/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.tm38fu
title: Occurrence Download

description: A dataset containing 14589088 species occurrences available in GBIF matching the query:
{
 "and" : [
 "BasisOfRecord is Specimen",
 {
 "or" : [
 "Country is Mexico",
 "Country is Costa Rica",
 "Country is Guatemala",
 "Country is Belize",
 "Country is El Salvador",
 "Country is Honduras",
 "Country is Nicaragua",
 "Country is Panama",
 "Country is Colombia"
 ]
 },
 "Geometry POLYGON((-99.58008 4.98588,-72.07031 1.40611,-75.67383 15.89371,-84.11133 18.57961,-88.04883 29.71859,-93.25195 29.59639,-96.06445 30.81169,-119.9707 34.13272,-99.58008 4.98588))",
 "HasCoordinate is true",
 "HasGeospatialIssue is false"
 ]
}

 The dataset includes 14589088 records from 2840 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0038830-210914110416597/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.quyx64
title: Occurrence Download

description: A dataset containing 94 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Ranunculus smirnovii Ovcz."
 ]
}

 The dataset includes 94 records from 8 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0100589-230530130749713/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.tvxhcq
title: Occurrence Download

description: A dataset containing 62101 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Penaeus aztecus Ives, 1891, Penaeus brasiliensis Latreille, 1817, Penaeus duorarum Burkenroad, 1939, Penaeus setiferus (Linnaeus, 1767), Penaeus monodon Fabricius, 1798, Rimapenaeus similis (S.I.Smith, 1885), Sicyonia brevirostris Stimpson, 1871, Xiphopenaeus kroyeri (Heller, 1862))",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 {
 "not" : {
 "BasisOfRecord" : [
 "is one of (Fossil, Living Specimen)"
 ]
 }
 },
 "Year 2000-2014"
 ]
}

 The dataset includes 62101 records from 59 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0025906-220831081235567/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.mx2ztq
title: Occurrence Download

description: A dataset containing 313 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Anolis tolimensis Werner, 1916"
 ]
}

 The dataset includes 313 records from 22 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0032512-200221144449610/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.j2xnj3
title: Occurrence Download

description: A dataset containing 195 species occurrences available in GBIF matching the query:
{
 "and" : [
 "VerbatimScientificName is Nucifraga multipunctata",
 "BasisOfRecord is one of (Machine Observation, Human Observation)",
 "Year 2011-2021",
 "HasCoordinate is true",
 "OccurrenceStatus is Present",
 {
 "not" : {
 "BasisOfRecord" : [
 "is one of (Fossil, Living Specimen, Specimen, Material citation, Material sample)"
 ]
 }
 }
 ]
}

 The dataset includes 195 records from 3 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0077817-230530130749713/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.fwkfkf
title: Occurrence Download

description: A dataset containing 48 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Echinocereus pulchellus (Mart.) Seitz"
 ]
}

 The dataset includes 48 records from 16 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0086469-220831081235567/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.rt1wsk
title: Occurrence Download

description: A dataset containing 4596 species occurrences available in GBIF matching the query:
{
 "DatasetKey" : [
 "is Inventaire des coléoptères saproxyliques de France métropolitaine - Collection de longicornes et autres coléoptères saproxyliques d'Hervé BRUSTEL"
 ]
}

 The dataset includes 4596 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0032521-200221144449610/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.5zdq7p
title: Occurrence Download

description: A dataset containing 1525994 species occurrences available in GBIF matching the query:
{
 "and" : [
 "VerbatimScientificName is Nycticorax nycticorax",
 "BasisOfRecord is one of (Machine Observation, Human Observation)",
 "Year 2011-2021",
 "HasCoordinate is true",
 "OccurrenceStatus is Present",
 {
 "not" : {
 "BasisOfRecord" : [
 "is one of (Fossil, Living Specimen, Specimen, Material citation, Material sample)"
 ]
 }
 }
 ]
}

 The dataset includes 1525994 records from 150 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0077859-230530130749713/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.au288z
title: Occurrence Download

description: A dataset containing 359 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Doris verrucosa Linnaeus, 1758"
 ]
}

 The dataset includes 359 records from 34 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0086465-220831081235567/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.swikrr
title: Occurrence Download

description: A dataset containing 89 species occurrences available in GBIF matching the query:
{
 "DatasetKey" : [
 "is CardObs : Observations naturalistes issues de l'outil CardObs-Données naturalistes de CALAS Jérome"
 ]
}

 The dataset includes 89 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0032551-200221144449610/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.jx84ze
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "VerbatimScientificName is Neomixis pallidior",
 "BasisOfRecord is one of (Machine Observation, Human Observation)",
 "Year 2011-2021",
 "HasCoordinate is true",
 "OccurrenceStatus is Present",
 {
 "not" : {
 "BasisOfRecord" : [
 "is one of (Fossil, Living Specimen, Specimen, Material citation, Material sample)"
 ]
 }
 }
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0090910-230530130749713/datasets/export for details.
DOI: 10.15468/dl.73h59q
title: Occurrence Download

description: A dataset containing 15 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is one of (Australia)",
 "BasisOfRecord is one of (Specimen)",
 "Year is greater than or equal to 1900",
 "TaxonKey is Pilosella officinarum Vaill.",
 "HasCoordinate is true",
 "HasGeospatialIssue is false"
 ]
}

 The dataset includes 15 records from 5 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0086484-220831081235567/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.57h2r9
title: Occurrence Download

description: A dataset containing 5380420 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Continent is Asia",
 "PublishingOrg is 28eb1a3f-1c15-4a95-931a-4af90ecb574d"
 ]
}

 The dataset includes 5380420 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0032993-231120084113126/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.9tviu7
title: Occurrence Download

description: A dataset containing 91 species occurrences available in GBIF matching the query:
{
 "DatasetKey" : [
 "is CardObs : Observations naturalistes issues de l'outil CardObs-Données naturalistes de EL ATTAR SOFI OUMAYMA"
 ]
}

 The dataset includes 91 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0032559-200221144449610/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.3vtrvf
title: Occurrence Download

description: A dataset containing 2 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Phyllanthus zornioides Radcl.-Sm."
 ]
}

 The dataset includes 2 records from 2 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0077862-230530130749713/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.ng7pky
title: Occurrence Download

description: A dataset containing 1011 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Doto coronata (Gmelin, 1791)"
 ]
}

 The dataset includes 1011 records from 61 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0086479-220831081235567/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.853snp
title: Occurrence Download

description: A dataset containing 1484 species occurrences available in GBIF matching the query:
{
 "and" : [
 "BasisOfRecord is Specimen",
 "Geometry POLYGON((-119.59992 31.37018,-105.46509 31.37018,-105.46509 37.02704,-119.59992 37.02704,-119.59992 31.37018))",
 "HasCoordinate is true",
 "TaxonKey is Crotalus atrox Baird & Girard, 1853",
 "HasGeospatialIssue is false"
 ]
}

 The dataset includes 1484 records from 34 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0067040-200221144449610/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.zg876c
title: Occurrence Download

description: A dataset containing 859 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Manis pentadactyla Linnaeus, 1758"
 ]
}

 The dataset includes 859 records from 67 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0206076-240321170329656/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.nru84p
title: Occurrence Download

description: A dataset containing 3 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Ascionana notaedorsalis Just & Wilson, 2004"
 ]
}

 The dataset includes 3 records from 2 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0113621-220831081235567/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.rcg2c8
title: Occurrence Download

description: A dataset containing 58 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Anisonotus curvirostris A.Milne-Edwards, 1879",
 "HasCoordinate is true"
 ]
}

 The dataset includes 58 records from 11 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0096280-230530130749713/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.zlqd07
title: Occurrence Download

description: A dataset containing 99 species occurrences available in GBIF matching the query:
{
 "DatasetKey" : [
 "is Enquête nationale Écrevisses - Données d'observation d'écrevisses exotiques envahissantes en Haut de France et Normandie sur la période 2014 à 2018"
 ]
}

 The dataset includes 99 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0032532-200221144449610/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.3gnuur
title: Occurrence Download

description: A dataset containing 64 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Diplostephium meyenii (Sch.Bip.) Wedd."
 ]
}

 The dataset includes 64 records from 16 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0025927-220831081235567/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.sqtssv
title: Occurrence Download

description: A dataset containing 201 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Ranunculus sphaerospermus Boiss. & Blanche"
 ]
}

 The dataset includes 201 records from 33 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0100594-230530130749713/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.dtsxsd
title: Occurrence Download

description: A dataset containing 10 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Geometry POLYGON((-18.03268 28.78418,-17.87338 28.41339,-17.73331 28.45459,-17.70035 28.83087,-17.89536 28.90778,-18.03268 28.78418))",
 "HasCoordinate is true",
 "TaxonKey is Cheirolophus santos-abreui A.Santos",
 "HasGeospatialIssue is false"
 ]
}

 The dataset includes 10 records from 4 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0040202-200221144449610/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.br5g6v
title: Occurrence Download

description: A dataset containing 2200 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Continent is North America",
 "Country is one of (United States of America, Canada)",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 "TaxonKey is Celtis occidentalis L.",
 "Year 1900-2000"
 ]
}

 The dataset includes 2200 records from 21 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0025921-220831081235567/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.5281/zenodo.11004395
title: Dataset / Code: Targeted protein degradation in mycobacteria uncovers antibacterial effects and potentiates antibiotic efficacy

description: Targeted protein degradation in mycobacteria uncovers antibacterial effects and potentiates antibiotic efficacy

 

Harim I. Won1,#, Samuel Zinga1,#, Olga Kandror1, Tatos Akopian1, Ian D. Wolf1, Jessica T.P. Schweber1, Ernst W. Schmid2, Michael C. Chao1, Maya Waldor1, Eric J. Rubin1,*, Junhao Zhu1,3,*

 

1Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, Massachusetts 02115, USA.

2Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Blavatnik Institute, Boston, Massachusetts 02115, USA.

3CAS Key Laboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.

#These authors contributed equally to this work.

*Corresponding authors: zhujh@im.ac.cn (J.Z.), erubin@hsph.harvard.edu (E. J. R.)

 

Abstract

Proteolysis-targeting chimeras (PROTACs) represent a new therapeutic modality involving selectively directing disease-causing proteins for degradation through proteolytic systems. Our ability to exploit targeted protein degradation (TPD) for antibiotic development remains nascent due to our limited understanding of which bacterial proteins are amenable to a TPD strategy. Here, we use a genetic system to model chemically-induced proximity and degradation to screen essential proteins in Mycobacterium smegmatis (Msm), a model for the human pathogen M. tuberculosis (Mtb). By integrating experimental screening of 72 protein candidates and machine learning, we find that drug-induced proximity to the bacterial ClpC1P1P2 proteolytic complex leads to the degradation of many endogenous proteins, especially those with disordered termini. Additionally, TPD of essential Msm proteins inhibits bacterial growth and potentiates the effects of existing antimicrobial compounds. Together, our results provide biological principles to select and evaluate attractive targets for future Mtb PROTAC development, as both standalone antibiotics and potentiators of existing antibiotic efficacy.
DOI: 10.15468/dl.8e6azu
title: Occurrence Download

description: A dataset containing 42108 species occurrences available in GBIF matching the query:
{
 "and" : [
 "VerbatimScientificName is Nycticorax caledonicus",
 "BasisOfRecord is one of (Machine Observation, Human Observation)",
 "Year 2011-2021",
 "HasCoordinate is true",
 "OccurrenceStatus is Present",
 {
 "not" : {
 "BasisOfRecord" : [
 "is one of (Fossil, Living Specimen, Specimen, Material citation, Material sample)"
 ]
 }
 }
 ]
}

 The dataset includes 42108 records from 22 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0077852-230530130749713/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.c0j11s
title: Occurrence Download

description: A dataset containing 33 species occurrences available in GBIF matching the query:
{
 "DatasetKey" : [
 "is CardObs : Observations naturalistes issues de l'outil CardObs-Données naturalistes de ALONSO Florian"
 ]
}

 The dataset includes 33 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0032548-200221144449610/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.5281/zenodo.10677006
title: Dataset / Code: Targeted protein degradation in mycobacteria uncovers antibacterial effects and potentiates antibiotic efficacy

description: Targeted protein degradation in mycobacteria uncovers antibacterial effects and potentiates antibiotic efficacy

 

Harim I. Won1,#, Samuel Zinga1,#, Olga Kandror1, Tatos Akopian1, Ian D. Wolf1, Jessica T.P. Schweber1, Ernst W. Schmid2, Michael C. Chao1, Maya Waldor1, Eric J. Rubin1,*, Junhao Zhu1,3,*

 

1Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, Massachusetts 02115, USA.

2Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Blavatnik Institute, Boston, Massachusetts 02115, USA.

3CAS Key Laboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.

#These authors contributed equally to this work.

*Corresponding authors: zhujh@im.ac.cn (J.Z.), erubin@hsph.harvard.edu (E. J. R.)

 

Abstract

Proteolysis-targeting chimeras (PROTACs) represent a new therapeutic modality involving selectively directing disease-causing proteins for degradation through proteolytic systems. Our ability to exploit targeted protein degradation (TPD) for antibiotic development remains nascent due to our limited understanding of which bacterial proteins are amenable to a TPD strategy. Here, we use a genetic system to model chemically-induced proximity and degradation to screen essential proteins in Mycobacterium smegmatis (Msm), a model for the human pathogen M. tuberculosis (Mtb). By integrating experimental screening of 72 protein candidates and machine learning, we find that drug-induced proximity to the bacterial ClpC1P1P2 proteolytic complex leads to the degradation of many endogenous proteins, especially those with disordered termini. Additionally, TPD of essential Msm proteins inhibits bacterial growth and potentiates the effects of existing antimicrobial compounds. Together, our results provide biological principles to select and evaluate attractive targets for future Mtb PROTAC development, as both standalone antibiotics and potentiators of existing antibiotic efficacy.