cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.19361442
title: Reflex single-gene non-invasive prenatal testing is associated with markedly better detection of fetuses affected with single-gene recessive disorders at lower cost

description: To evaluate the clinical benefits and achievable cost savings associated with the adoption of a carrier screen with reflex single-gene non-invasive prenatal test (sgNIPT) in prenatal care. A decision-analytic model was developed to compare carrier screen with reflex sgNIPT (maternal carrier status and fetal risk reported together) as first-line carrier screening to the traditional carrier screening workflow (positive maternal carrier screen followed by paternal screening to evaluate fetal risk). The model compared the clinical outcomes and healthcare costs associated with the two screening methods. These results were used to simulate appropriate pricing for reflex sgNIPT. Reflex sgNIPT carrier screening-detected 108 of 110 affected pregnancies per 100,000 births (98.5% sensitivity), whereas traditional carrier screening-detected 46 of 110 affected pregnancies (41.5% sensitivity). The cost to identify one affected pregnancy was reduced by 62% in the reflex sgNIPT scenario compared to the traditional scenario. Adding together the testing cost savings and the savings from earlier clinical intervention made possible by reflex sgNIPT, the total cost savings was $37.6 million per 100,000 pregnancies. Based on these cost savings, we simulated appropriate reflex sgNIPT pricing range: if the cost to identify one affected pregnancy is the unit cost, carrier screening with reflex sgNIPT can be priced up to $1,859 per test (or $7,233 if sgNIPT is billed separately); if the cost per 100,000 pregnancies is the unit cost, carrier screening with sgNIPT can be priced up to $1,070 per test (or $2,336 if sgNIPT is billed separately). Using the carrier screen with reflex sgNIPT as first-line screening improves the detection of affected fetuses by 2.4-fold and can save costs for the healthcare system. A real-life experience will be needed to assess the clinical utility and exact cost savings of carrier screen with reflex sgNIPT.
DOI: 10.6084/m9.figshare.19361442.v1
title: Reflex single-gene non-invasive prenatal testing is associated with markedly better detection of fetuses affected with single-gene recessive disorders at lower cost

description: To evaluate the clinical benefits and achievable cost savings associated with the adoption of a carrier screen with reflex single-gene non-invasive prenatal test (sgNIPT) in prenatal care. A decision-analytic model was developed to compare carrier screen with reflex sgNIPT (maternal carrier status and fetal risk reported together) as first-line carrier screening to the traditional carrier screening workflow (positive maternal carrier screen followed by paternal screening to evaluate fetal risk). The model compared the clinical outcomes and healthcare costs associated with the two screening methods. These results were used to simulate appropriate pricing for reflex sgNIPT. Reflex sgNIPT carrier screening-detected 108 of 110 affected pregnancies per 100,000 births (98.5% sensitivity), whereas traditional carrier screening-detected 46 of 110 affected pregnancies (41.5% sensitivity). The cost to identify one affected pregnancy was reduced by 62% in the reflex sgNIPT scenario compared to the traditional scenario. Adding together the testing cost savings and the savings from earlier clinical intervention made possible by reflex sgNIPT, the total cost savings was $37.6 million per 100,000 pregnancies. Based on these cost savings, we simulated appropriate reflex sgNIPT pricing range: if the cost to identify one affected pregnancy is the unit cost, carrier screening with reflex sgNIPT can be priced up to $1,859 per test (or $7,233 if sgNIPT is billed separately); if the cost per 100,000 pregnancies is the unit cost, carrier screening with sgNIPT can be priced up to $1,070 per test (or $2,336 if sgNIPT is billed separately). Using the carrier screen with reflex sgNIPT as first-line screening improves the detection of affected fetuses by 2.4-fold and can save costs for the healthcare system. A real-life experience will be needed to assess the clinical utility and exact cost savings of carrier screen with reflex sgNIPT.
DOI: 10.6084/m9.figshare.19358561
title: Unveiling the diversity of Giant Neotropical Torrent frogs (Hylodidae): phylogenetic relationships, morphology, and the description of two new species

description: The Neotropical family Hylodidae comprises 46 currently recognized rheophilic Torrent frog species, today classified in the genera <i>Crossodactylus</i>, <i>Hylodes</i>, <i>Megaelosia</i>, and <i>Phantasmarana</i>, all endemic to the Atlantic Forest. <i>Megaelosia</i> and <i>Phantasmarana</i> are distributed along the Serra do Mar and Serra da Mantiqueira mountain ranges, southeastern Brazil, and are the least speciose genera of the family, including all the mute giant hylodids. <i>Megaelosia</i> is a monotypic genus, whereas <i>Phantasmarana</i> comprises six currently recognized species: <i>P. apuana</i>, <i>P. bocainensis</i>, <i>P. boticariana</i>, <i>P. jordanensis</i>, <i>P. lutzae</i>, and <i>P. massarti</i>. Herein, we provide a taxonomic revision of these Giant Neotropical Torrent frogs, offering a comprehensively sampled species-level molecular phylogeny. By combining molecular and morphological data, we confirm that <i>Megaelosia</i> and <i>Phantasmarana</i> are valid genera. We provide diagnostic traits for both genera, redescribe the poorly known species <i>P. jordanensis</i>, and describe two new species from distinct localities at Parque Estadual da Serra do Mar, <i>P. curucutuensis</i> sp. nov. and <i>P. tamuia</i> sp. nov., presenting details of adult and larval morphology, and notes on their natural history and behaviour. We further discuss systematic and taxonomic concerns, and evolutionary processes related to distribution, body sizes, and communication in the family Hylodidae. http://zoobank.org/urn:lsid:zoobank.org:pub:61EA0116-6FB9-44B8-A2CE-E99D7B887E8B http://zoobank.org/urn:lsid:zoobank.org:act:079339E6-C802-4B47-A3A3-9FA0D0FCA3D1 http://zoobank.org/urn:lsid:zoobank.org:act:0EA22628-89E9-483B-AB90-F3F0D18E28F1
DOI: 10.6084/m9.figshare.19358561.v3
title: Unveiling the diversity of Giant Neotropical Torrent frogs (Hylodidae): phylogenetic relationships, morphology, and the description of two new species

description: The Neotropical family Hylodidae comprises 46 currently recognized rheophilic Torrent frog species, today classified in the genera <i>Crossodactylus</i>, <i>Hylodes</i>, <i>Megaelosia</i>, and <i>Phantasmarana</i>, all endemic to the Atlantic Forest. <i>Megaelosia</i> and <i>Phantasmarana</i> are distributed along the Serra do Mar and Serra da Mantiqueira mountain ranges, southeastern Brazil, and are the least speciose genera of the family, including all the mute giant hylodids. <i>Megaelosia</i> is a monotypic genus, whereas <i>Phantasmarana</i> comprises six currently recognized species: <i>P. apuana</i>, <i>P. bocainensis</i>, <i>P. boticariana</i>, <i>P. jordanensis</i>, <i>P. lutzae</i>, and <i>P. massarti</i>. Herein, we provide a taxonomic revision of these Giant Neotropical Torrent frogs, offering a comprehensively sampled species-level molecular phylogeny. By combining molecular and morphological data, we confirm that <i>Megaelosia</i> and <i>Phantasmarana</i> are valid genera. We provide diagnostic traits for both genera, redescribe the poorly known species <i>P. jordanensis</i>, and describe two new species from distinct localities at Parque Estadual da Serra do Mar, <i>P. curucutuensis</i> sp. nov. and <i>P. tamuia</i> sp. nov., presenting details of adult and larval morphology, and notes on their natural history and behaviour. We further discuss systematic and taxonomic concerns, and evolutionary processes related to distribution, body sizes, and communication in the family Hylodidae. http://zoobank.org/urn:lsid:zoobank.org:pub:61EA0116-6FB9-44B8-A2CE-E99D7B887E8B http://zoobank.org/urn:lsid:zoobank.org:act:079339E6-C802-4B47-A3A3-9FA0D0FCA3D1 http://zoobank.org/urn:lsid:zoobank.org:act:0EA22628-89E9-483B-AB90-F3F0D18E28F1
DOI: 10.6084/m9.figshare.19358561.v2
title: Unveiling the diversity of Giant Neotropical Torrent frogs (Hylodidae): phylogenetic relationships, morphology, and the description of two new species

description: The Neotropical family Hylodidae comprises 46 currently recognized rheophilic Torrent frog species, today classified in the genera <i>Crossodactylus</i>, <i>Hylodes</i>, <i>Megaelosia</i>, and <i>Phantasmarana</i>, all endemic to the Atlantic Forest. <i>Megaelosia</i> and <i>Phantasmarana</i> are distributed along the Serra do Mar and Serra da Mantiqueira mountain ranges, southeastern Brazil, and are the least speciose genera of the family, including all the mute giant hylodids. <i>Megaelosia</i> is a monotypic genus, whereas <i>Phantasmarana</i> comprises six currently recognized species: <i>P. apuana</i>, <i>P. bocainensis</i>, <i>P. boticariana</i>, <i>P. jordanensis</i>, <i>P. lutzae</i>, and <i>P. massarti</i>. Herein, we provide a taxonomic revision of these Giant Neotropical Torrent frogs, offering a comprehensively sampled species-level molecular phylogeny. By combining molecular and morphological data, we confirm that <i>Megaelosia</i> and <i>Phantasmarana</i> are valid genera. We provide diagnostic traits for both genera, redescribe the poorly known species <i>P. jordanensis</i>, and describe two new species from distinct localities at Parque Estadual da Serra do Mar, <i>P. curucutuensis</i> sp. nov. and <i>P. tamuia</i> sp. nov., presenting details of adult and larval morphology, and notes on their natural history and behaviour. We further discuss systematic and taxonomic concerns, and evolutionary processes related to distribution, body sizes, and communication in the family Hylodidae. http://zoobank.org/urn:lsid:zoobank.org:pub:61EA0116-6FB9-44B8-A2CE-E99D7B887E8B http://zoobank.org/urn:lsid:zoobank.org:act:079339E6-C802-4B47-A3A3-9FA0D0FCA3D1 http://zoobank.org/urn:lsid:zoobank.org:act:0EA22628-89E9-483B-AB90-F3F0D18E28F1
DOI: 10.6084/m9.figshare.13181990
title: Carbon catabolite repression in filamentous fungi is regulated by phosphorylation of the transcription factor CreA

description: Filamentous fungi of the genus <i>Aspergillus</i>, are of particular interest for biotechnological applications due to their natural capacity to secrete carbohydrate-active enzymes (CAZy) that target plant biomass. The presence of easily metabolizable sugars such as glucose, whose concentrations increase during plant biomass hydrolysis, results in the repression of CAZy-encoding genes, in a process known as carbon catabolite repression (CCR), which is undesired for the purpose of large-scale enzyme production. To date, the C<sub>2</sub>H<sub>2</sub> transcription factor CreA has been described as the major CC-repressor in <i>Aspergillus spp</i>, although little is known about the role of post-translational modifications in this process. In this work, phosphorylation sites were identified by mass spectrometry on <i>Aspergillus nidulans</i> CreA, and subsequently, the previously identified but uncharacterized site S262, the characterized site S319, and the newly identified sites S268 and T308, were chosen to be mutated to non-phosphorylatable residues before their effect on CCR was investigated. Sites S262, S268 and T308 are important for CreA protein accumulation and cellular localization, DNA binding and repression of enzyme activities. In agreement with a previous study, site S319 was not important for several here tested phenotypes, but is key for CreA degradation and induction of enzyme activities. All sites were shown to be important for glycogen and trehalose metabolism. This study highlights the importance of CreA phosphorylation sites for the regulation of CCR. These sites are interesting targets for biotechnological strain engineering without the need to delete essential genes, which could result in undesired side effects. <b> </b>
DOI: 10.6084/m9.figshare.13181990.v1
title: Carbon catabolite repression in filamentous fungi is regulated by phosphorylation of the transcription factor CreA

description: Filamentous fungi of the genus <i>Aspergillus</i>, are of particular interest for biotechnological applications due to their natural capacity to secrete carbohydrate-active enzymes (CAZy) that target plant biomass. The presence of easily metabolizable sugars such as glucose, whose concentrations increase during plant biomass hydrolysis, results in the repression of CAZy-encoding genes, in a process known as carbon catabolite repression (CCR), which is undesired for the purpose of large-scale enzyme production. To date, the C<sub>2</sub>H<sub>2</sub> transcription factor CreA has been described as the major CC-repressor in <i>Aspergillus spp</i>, although little is known about the role of post-translational modifications in this process. In this work, phosphorylation sites were identified by mass spectrometry on <i>Aspergillus nidulans</i> CreA, and subsequently, the previously identified but uncharacterized site S262, the characterized site S319, and the newly identified sites S268 and T308, were chosen to be mutated to non-phosphorylatable residues before their effect on CCR was investigated. Sites S262, S268 and T308 are important for CreA protein accumulation and cellular localization, DNA binding and repression of enzyme activities. In agreement with a previous study, site S319 was not important for several here tested phenotypes, but is key for CreA degradation and induction of enzyme activities. All sites were shown to be important for glycogen and trehalose metabolism. This study highlights the importance of CreA phosphorylation sites for the regulation of CCR. These sites are interesting targets for biotechnological strain engineering without the need to delete essential genes, which could result in undesired side effects. <b> </b>
DOI: 10.5519/qd.xyqe1qbe
title: Query on the Natural History Museum Data Portal (data.nhm.ac.uk) (79 records)
DOI: 10.5281/zenodo.6379267
title: Electropherogram data of endogenous compounds in DBS

description: Electropherogram data (in CSV) and calibration data of the SI-CE-C4D system for endogenous analytes of dried blood spots associated to Fig. 6 of the paper "Automated Sequential Injection-Capillary Electrophoresis for Dried Blood Spot Analysis: A Proof-of-Concept Study" published in Analytical Chemistry, 2022 (10.1021/acs.analchem.1c05130)
description: Dep Química, Carretera Valldemoss km 7,5
DOI: 10.5281/zenodo.6379266
title: Electropherogram data of endogenous compounds in DBS

description: Electropherogram data (in CSV) and calibration data of the SI-CE-C4D system for endogenous analytes of dried blood spots associated to Fig. 6 of the paper "Automated Sequential Injection-Capillary Electrophoresis for Dried Blood Spot Analysis: A Proof-of-Concept Study" published in Analytical Chemistry, 2022 (10.1021/acs.analchem.1c05130)
description: Dep Química, Carretera Valldemoss km 7,5
DOI: 10.5281/zenodo.6379996
title: coleccion_anagrama

description: Dataset de los títulos de la editorial Anagrama
DOI: 10.5281/zenodo.6379995
title: coleccion_anagrama

description: Dataset de los títulos de la editorial Anagrama
DOI: 10.48786/edbt.2022.49
title: JupySim: Jupyter Notebook Similarity Search System
DOI: 10.48786/edbt.2022.50
title: SheerMP: Optimized Streaming Analytics-as-a-Service over Multi-site and Multi-platform Settings
DOI: 10.48786/edbt.2022.28
title: Fine-Tuning Dependencies with Parameters
DOI: 10.48786/edbt.2022.29
title: RoleSim+: A Fast Algorithm for RoleSim Similarity Search
DOI: 10.48786/edbt.2022.30
title: Spatially Combined Keyword Searches
DOI: 10.48786/edbt.2022.31
title: Similarity-driven Schema Transformation for Test Data Generation
DOI: 10.48786/edbt.2022.51
title: AVID: GPU-enabled Visual Analytics with GPU-FAST-PROCLUS
DOI: 10.48786/edbt.2022.32
title: Towards A General SIMD Concurrent Approach to Accelerating Integer Compression Algorithms
DOI: 10.48786/edbt.2022.33
title: Columnar Storage Optimization and Caching for Data Lakes
DOI: 10.48786/edbt.2022.34
title: Cache-Coherent Shared Locking for Transactionally Consistent Updates in Near-Data Processing DBMS on Smart Storage
DOI: 10.48786/edbt.2022.35
title: Query Language Support for Timely Data Deletion
DOI: 10.48786/edbt.2022.36
title: Bias-aware Fair Neural Ranking for Addressing Stereotypical Gender Biases
DOI: 10.48786/edbt.2022.38
title: Diversified Top-r Community Search in Geo-Social Network: A K-Truss Based Model
DOI: 10.48786/edbt.2022.53
title: An Extensive and Secure Personal Data Management System Using SGX
DOI: 10.48786/edbt.2022.54
title: MAGE: Discovering Mixture-based Areas of Interest over Geolocated Entities
DOI: 10.48786/edbt.2022.55
title: DP-Shield: Face Obfuscation with Differential Privacy
DOI: 10.48786/edbt.2022.48
title: Distributed Training of Knowledge Graph Embedding Models using Ray
DOI: 10.48786/edbt.2022.01
title: Mining Change Rules
DOI: 10.48786/edbt.2022.41
title: Bipartite Graph Matching Algorithms for Clean-Clean Entity Resolution: An Empirical Evaluation
DOI: 10.48786/edbt.2022.03
title: TransER: Homogeneous Transfer Learning for Entity Resolution
DOI: 10.48786/edbt.2022.04
title: Differentially-Private Publication of Origin-Destination Matrices with Intermediate Stops
DOI: 10.48786/edbt.2022.05
title: SURAGH: Syntactic Pattern Matching to Identify Ill-Formed Records
DOI: 10.48786/edbt.2022.06
title: SWIRL: Selection of Workload-aware Indexes using Reinforcement Learning
DOI: 10.48786/edbt.2022.22
title: Detecting Errors in Databases with Bidirectional Recurrent Neural Networks
DOI: 10.48786/edbt.2022.08
title: An Indexable Time Series Dimensionality Reduction Method for Maximum Deviation Reduction and Similarity Search
DOI: 10.48786/edbt.2022.09
title: GPU-FAST-PROCLUS: A Fast GPU-parallelized Approach to Projected Clustering
DOI: 10.48786/edbt.2022.10
title: Aggregation Detection in CSV Files
DOI: 10.48786/edbt.2022.40
title: PReVer: Towards Private Regulated Verified Data
DOI: 10.48786/edbt.2022.11
title: A Supervised Skyline-Based Algorithm for Spatial Entity Linkage
DOI: 10.48786/edbt.2022.42
title: Evaluation of Algorithms for Interaction-Sparse Recommendations: Neural Networks don't Always Win [Experiments & Analysis]
DOI: 10.48786/edbt.2022.13
title: Unsupervised Selectivity Estimation by Integrating Gaussian Mixture Models and an Autoregressive Model
DOI: 10.48786/edbt.2022.15
title: Automatic generation of comparison notebooks for interactive data exploration
DOI: 10.48786/edbt.2022.16
title: Cardinality Estimation using Label Probability Propagation for Subgraph Matching in Property Graph Databases
DOI: 10.48786/edbt.2022.18
title: Elastic Indexes: Dynamic Space vs. Query Efficiency Tuning for In-Memory Database Indexing
DOI: 10.48786/edbt.2022.19
title: Backbone Index to Support Skyline Path Queries over Multi-cost Road Networks
DOI: 10.48786/edbt.2022.20
title: Towards Optimal Resource Allocation for Big Data Analytics
DOI: 10.48786/edbt.2022.43
title: Placement of Workloads from Advanced RDBMS Architectures into Complex Cloud Infrastructure
DOI: 10.48786/edbt.2022.44
title: Unsupervised Graph-based Entity Resolution for Accurate and Efficient Family Pedigree Search
DOI: 10.48786/edbt.2022.45
title: Integrating the Orca Optimizer into MySQL
DOI: 10.48786/edbt.2022.24
title: DataGossip: A Data Exchange Extension for Distributed Machine Learning Algorithms
DOI: 10.48786/edbt.2022.25
title: Translation Grids for Multi-way Join Size Estimation
DOI: 10.48786/edbt.2022.26
title: Masked Language Models as Stereotype Detectors?
DOI: 10.48786/edbt.2022.27
title: Implementing Linear Bandits in Off-the-Shelf SQLite
DOI: 10.5445/ir/1000143860
title: TEM original data of the LNO (pristine and heat treated) samples
DOI: 10.48786/edbt.2022.46
title: Model-Independent Design of Knowledge Graphs --- Lessons Learnt From Complex Financial Graphs
DOI: 10.17909/p64t-z134
title: Hubble quasar spectra

description: AST 521 class project
DOI: 10.5281/zenodo.6376250
title: Dataset: Reassessing the potential of TlCl for laser cooling experiments via four-component correlated electronic strucure calculations

description: This dataset collects the unprocessed (= outputs from calculations) results discussed in the paper titled "A Reassessing the potential of TlCl for laser cooling experiments via four-component correlated electronic strucure calculations", by Xiang Yuan and Andre Severo Pereira Gomes. It also contains the figures used in the manuscript, and the scripts to carry out the number of scattered photons and cooling simulations described in the paper
DOI: 10.5281/zenodo.6376249
title: Dataset: Reassessing the potential of TlCl for laser cooling experiments via four-component correlated electronic strucure calculations

description: This dataset collects the unprocessed (= outputs from calculations) results discussed in the paper titled "A Reassessing the potential of TlCl for laser cooling experiments via four-component correlated electronic strucure calculations", by Xiang Yuan and Andre Severo Pereira Gomes. It also contains the figures used in the manuscript, and the scripts to carry out the number of scattered photons and cooling simulations described in the paper
DOI: 10.5285/703acf75-8996-45a4-b4b3-42afca269a1c
title: Compilation of Mineral and Glass Compositions erupted at Villarrica volcano, Chile

description: A compilation of mineral and glass compositions erupted at Villarrica volcano, Chile, measured by electron microprobe. Data are sourced from published articles, theses and unpublished works. Minerals and glasses are from deposits erupted over the last 100ka.
This is supporting data for the manuscript entitled 'Insights into Magma Storage Beneath a Frequently Erupting Arc Volcano (Villarrica, Chile) from Unsupervised Machine Learning Analysis of Mineral Compositions' by F. O. Boschetty, D. J. Ferguson, J. A Cortés, E. Morgado, S. K. Ebmeier, D. J. Morgan, J. E. Romero and C. Silva Parejas.
DOI: 10.6084/m9.figshare.19105181
title: breast-cancer-atlas-labelled

description: Breast Cancer Atlas Data from https://doi.org/10.1016/j.cell.2019.03.005
DOI: 10.6084/m9.figshare.19105181.v5
title: breast-cancer-atlas-labelled

description: Breast Cancer Atlas Data from https://doi.org/10.1016/j.cell.2019.03.005
DOI: 10.6084/m9.figshare.19105181.v4
title: breast-cancer-atlas-labelled

description: Breast Cancer Atlas Data from https://doi.org/10.1016/j.cell.2019.03.005
DOI: 10.5523/bris.1ugskiuvmlcmu2tn9682fwa36h
title: Artificial SA-I, RA-I and RA-II/Vibrotactile Afferents for Tactile Sensing of Texture

description: ***Superseded by DOI 10.5523/bris.3ex175ojw0ckt25icp6g6p9j12 afferents-tactile-textures-jrsi2022*** Data from paper published in Journal Royal Society Interface
DOI: 10.3886/e163943
title: 2015-2019 ACS PUMS Data for Middle Eastern and North African Health Research

description: The overall purpose if to provide recent national estimates of US- and foreign-born MENA populationsObjectives: 1) To estimate the proportion of foreign-born whites from North African countries compared to other African countries; 2) To estimate the US population of MENA children (ages &lt;18 years); 3) To estimate the US population of MENA adults (ages 18+ years); and 4) To estimate the US population of MENA older adults (ages 65+ years).
DOI: 10.3886/e163943v1
title: 2015-2019 ACS PUMS Data for Middle Eastern and North African Health Research

description: The overall purpose if to provide recent national estimates of US- and foreign-born MENA populationsObjectives: 1) To estimate the proportion of foreign-born whites from North African countries compared to other African countries; 2) To estimate the US population of MENA children (ages &lt;18 years); 3) To estimate the US population of MENA adults (ages 18+ years); and 4) To estimate the US population of MENA older adults (ages 65+ years).