DOI: 10.5281/zenodo.15126574
title: Dataset for the article "Plasticity of interhemispheric motor cortex connectivity induced by brain state-dependent cortico-cortical paired-associative stimulation"

description: This repository contains a dataset supporting results reported in: 

Ermolova, M., Kozak, G., Belardinelli, P., & Ziemann, U. (2025). Plasticity of interhemispheric motor cortex connectivity induced by brain state-dependent cortico-cortical paired-associative stimulation. bioRxiv, 2025-04.

Overview

In this study, healthy subjects received cortico-cortical paired associative stimulation (ccPAS) under four different µ-phase conditions targeting the left (conditioning) M1 and right (test) M1: trough-trough, trough-positive peak, positive peak-trough, and random phase. Short interhemispheric inhibition (SIHI) and resting-state EEG were recorded before and after the intervention. Further details are provided in the associated publication.

The dataset is intended for use with the code available at: https://github.com/mariaermolova/M1M1PAS

Dataset Structure

1. SIHIdata.csv

Single-trial conditioned MEP amplitudes elicited by paired-pulse stimulation. MEP amplitudes are normalized by (i.e., divided by) the average unconditioned MEP amplitude from the same recording. MEP amplitudes from the conditioning site (FDIr and APBr) are also given.

Columns:





Subject: Subject ID




Intervention: Phase-targeting condition




Time: Time of measurement relative to intervention




Channel: EMG channel (muscle)




Intensity: Conditioning pulse intensity (%MSO)




Response: Conditioned MEP amplitude, normalized



Labels:





Intervention types:





negneg = trough-trough




negpos = trough-positive peak




posneg = positive peak-trough




random = random phase






Time points:





Pre = pre-intervention




0 = immediately post-intervention




30 = 30 minutes post-intervention




60 = 60 minutes post-intervention






Channels:





FDIr = First Dorsal Interosseous (right hand, conditioning site)




ABPr = Abductor Pollicis Brevis (right hand)




FDIl = First Dorsal Interosseous (left hand, conditioned/test site)




APBl = Abductor Pollicis Brevis (left hand)





2. MEPdataPP.csv

Same structure as SIHIdata.csv, but MEP amplitudes are not normalized (i.e., raw conditioned MEP amplitudes, in µV).

3. MEPdataSP.csv

Same structure as SIHIdata.csv. Single-trial unconditioned MEP amplitudes, elicited by single-pulse stimulation of the test site (in µV).

4. sourceConnectivity.csv

Single-epoch alpha-band wPLI values from resting-state EEG.

Columns:





Subject: Subject ID




Intervention: Intervention type




Time: Time of measurement




wpli: Weighted Phase Lag Index (wPLI) value



Labels:





Run numbers:





1 = First pre-intervention recording




2 = Second pre-intervention recording




3 = 0 min post-intervention




4 = 30 min post-intervention




5 = 60 min post-intervention





5. sourcePhLag.csv

Same structure as sourceConnectivity.csv. Instantaneous phase lags between right and left M1 alpha-band signals from resting-state EEG.

Columns:





Subject: Subject ID




Intervention: Intervention type




Time: Time of measurement




Phase_lag: Instantaneous phase lag (in radians)



Notes





In the EMG recordings, the right hand corresponds to the conditioning hemisphere (left M1 stimulation), and the left hand corresponds to the conditioned/test hemisphere (right M1 stimulation).




In sourceConnectivity.csv, the first baseline (Time = 1) was removed in some analyses to match available SIHI data.