cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.25387/g3.7607060.v3
title: Supplemental Material for Xu et al., 2019

description: Supplemental Tables S1, S2, S3; <br>Supplemental Figures S1, S2;Supplemental Files S1, S2
DOI: 10.6084/m9.figshare.7082459
title: Role of plant respiratory burst oxidase homologs in stress responses

description: Plant respiratory burst oxidase homologs (Rbohs), which are also named nicotinamide adenine dinucleotide phosphate (NADPH) oxidases (NOXs), are the homologs of mammalian phagocyte gp91<sup>phox</sup>. As a unique among other reactive oxygen species (ROS) production mechanisms in plants, NADPH oxidases can integrate different signal transduction pathways, such as calcium, protein phosphorylation catalysed by protein kinases, nitric oxide, and lipid messengers. Coupling with genetic studies, the ability of plant NADPH oxidases to integrate different signal transduction pathways with ROS production demonstrates their involvement in many important biological processes in cells, such as morphogenesis and development, and stress responses. Here, we focus on several current studies concerning the role of plant NADPH oxidases in stress responses.
DOI: 10.6084/m9.figshare.19664371.v1
title: Additional file 3 of Factors influencing bedtime procrastination in junior college nursing students: a cross-sectional study

description: Additional file 3.
DOI: 10.6084/m9.figshare.12849719.v1
title: A Nonparametric Non-classical Measurement Error Approach to Estimating Intergenerational Mobility Elasticities*

description: This paper provides a framework for estimating intergenerational mobility elasticities (IGE) of children’s income with respect to parental income. We allow the IGEs to be heterogeneous, by leaving the relationship of parental and child incomes unspecified, while acknowledging and addressing the <i>latent</i> nature of both child and parental <i>permanent</i> incomes and the resulted life-cycle bias. Our framework enables us to test the widely imposed assumption that the intergenerational mobility function is linear. Applying our method to the Panel Studies of Income Dynamics (PSID) data, we decisively reject the commonly imposed linearity assumption and find substantial heterogeneity in the IGEs across the population. We confirm an important finding that the IGEs with respect to parental income exhibit a U-shape pattern, which is occasionally highlighted in the analysis using transition matrices. Specifically, there is a considerable degree of mobility among the broadly defined middle class, but the children of both high- and low-income parents are more likely to be high- and low-income adults, respectively. This result also provides insights into the (intertemporal) Great Gatsby curve, suggesting that a higher level of inequality within one generation may lead to a higher level of social immobility in the next generation in the U.S..
DOI: 10.6084/m9.figshare.19665470
title: Role of circRNA circ_0000080 in myocardial hypoxia injury

description: This study aimed to investigate the potential role of circRNA circ_0000080 in myocardial hypoxia injury and the underlying mechanisms. Patients with myocardial hypoxia injury who were admitted to Xi’an No. 1 Hospital, China, were included in this study. The expression levels of circ_0000080, miR-367-5p, and <i>COX2</i> were analyzed by real-time quantitative PCR (RT-qPCR); cell viability was measured by cell counting kit-8 (CCK-8) assay; and apoptosis was detected by flow cytometry. In addition, the release of cytokines was determined by Enzyme-linked immunosorbent assay (ELISA), and the binding sites between miR-367-5p and circ_0000080/<i>COX2</i> were predicted by bioinformatics analysis and confirmed by dual-luciferase reporter and RNA pull-down assays. circ_0000080 was upregulated in patients with MI and in H9c2 cells treated with H<sub>2</sub>O<sub>2</sub> and hypoxia/reoxygenation (H/R). Silencing circ_0000080 reduced the H/R-mediated apoptosis of cardiomyocytes and secretion of pro-inflammatory cytokines. Moreover, circ_0000080 functioned as an miR-367-5p sponge to regulate the expression of <i>COX2</i>. Downregulated miR-367-5p or overexpressed <i>COX2</i> degraded cellular functions of cardiomyocytes. circ_0000080 knockdown alleviated myocardial hypoxia injury through the miR-367-5p/<i>COX2</i> axis.
DOI: 10.6084/m9.figshare.25224722
title: <b>hsa-miR-610,</b><b> </b><b>hsa-miR-495-3p, and hsa-miR-1273h-5p</b> <b>Regulates Phenotypic Plasticity, Conferring TKI Resistance and Immune Escape in Chronic Myeloid Leukemia Cells</b>

description: miRNAs data
DOI: 10.6084/m9.figshare.25224722.v1
title: <b>hsa-miR-610,</b><b> </b><b>hsa-miR-495-3p, and hsa-miR-1273h-5p</b> <b>Regulates Phenotypic Plasticity, Conferring TKI Resistance and Immune Escape in Chronic Myeloid Leukemia Cells</b>

description: miRNAs data
DOI: 10.6084/m9.figshare.19665470.v1
title: Role of circRNA circ_0000080 in myocardial hypoxia injury

description: This study aimed to investigate the potential role of circRNA circ_0000080 in myocardial hypoxia injury and the underlying mechanisms. Patients with myocardial hypoxia injury who were admitted to Xi’an No. 1 Hospital, China, were included in this study. The expression levels of circ_0000080, miR-367-5p, and <i>COX2</i> were analyzed by real-time quantitative PCR (RT-qPCR); cell viability was measured by cell counting kit-8 (CCK-8) assay; and apoptosis was detected by flow cytometry. In addition, the release of cytokines was determined by Enzyme-linked immunosorbent assay (ELISA), and the binding sites between miR-367-5p and circ_0000080/<i>COX2</i> were predicted by bioinformatics analysis and confirmed by dual-luciferase reporter and RNA pull-down assays. circ_0000080 was upregulated in patients with MI and in H9c2 cells treated with H<sub>2</sub>O<sub>2</sub> and hypoxia/reoxygenation (H/R). Silencing circ_0000080 reduced the H/R-mediated apoptosis of cardiomyocytes and secretion of pro-inflammatory cytokines. Moreover, circ_0000080 functioned as an miR-367-5p sponge to regulate the expression of <i>COX2</i>. Downregulated miR-367-5p or overexpressed <i>COX2</i> degraded cellular functions of cardiomyocytes. circ_0000080 knockdown alleviated myocardial hypoxia injury through the miR-367-5p/<i>COX2</i> axis.
DOI: 10.6084/m9.figshare.12850004.v1
title: Clinical and molecular characteristics associated with survival among cancer patients receiving first-line anti-PD-1/PD-L1-based therapies

description: Anti-PD-1/PD-L1-based therapy has emerged recently, and we aimed to figure out the latent value of different clinical and molecular factors to predict the efficacy of immune checkpoint inhibitors (ICIs) therapy compared with non-immunotherapy in the first-line setting. We assessed the clinical outcomes of 8711 patients in 13 trials receiving anti-PD-1/PD-L1-based therapy or non-immunotherapy as first-line treatment, and different predictors were investigated. Overall, compared with non-immunotherapy, anti-PD-1/PD-L1-based therapy reduced the risk of death by 31% (HR 0.69, 95%CI: 0.60–0.79) for all cancers. Stratified analysis showed that the progression-free survival (PFS) benefit from anti-PD-1/PD-L1-based therapy existed in all three PD-L1 status subgroups (tumour proportion score, TPS ≥50%: HR 0.54, 95%CI: 0.38–0.78; TPS 1–49%: HR 0.56, 95%CI: 0.46–0.68; TPS &lt;1%: HR 0.82, 95%CI: 0.73–0.91; interaction, <i>p</i> &lt; 0.01). ICI therapy also prolonged PFS in males (HR 0.64, 95%CI: 0.50–0.83) and younger patients (HR 0.70, 95%CI: 0.52–0.93), and they might prolong overall survival (OS) in patients without brain metastasis (HR 0.54, 95%CI: 0.41–0.71). PD-L1 expression level alone is imperfect to predict the efficacy of anti-PD-1/PD-L1-based therapies as first-line cancer treatment. Meanwhile, sex, age, and status of brain metastases might also be predictive parameters for the selection of cancer patients.
DOI: 10.25413/sun.23545428
title: Towards strengthening of rehabilitation at primary care: exploring the needs and perspectives regarding rehabilitation services in two low resource contexts

description: File A: Coded data from participant responses for adult patients and primary care providers from the Eastern Cape (EC), South Africa (SA) and Manicaland, Zimbabwe.<br>
DOI: 10.6084/m9.figshare.12849821.v1
title: Genetic structure and forensic characterisation of 36 Y-chromosomal STR loci in Hmong-Mien-speaking Miao population

description: Y-chromosomal short tandem repeats (Y-STRs) are widely used in paternity identification, pedigree investigation, and human population genetic history. To investigate the Y-STR polymorphisms in a typical Miao population, and explore the genetic differentiation between the Miao population and reference groups. We detected 36 Y-STRs genotyping in 455 unrelated Miao individuals from Guizhou province, and analysed genetic differentiation between the Miao population and 76 reference groups. A total of 369 alleles were obtained, and the allele frequencies ranged from 0.0022 to 0.9802. In addition, the haplotype diversity, random match probability, and discrimination capacity values were 0.99997, 0.0022, and 0.9934, respectively. Moreover, the genetic relationships between Guizhou Miao and 76 ethnic populations showed that the population stratification was almost consistent with geographic distribution and language-family. The 36 Y-STR loci in this study have good polymorphism distributions in the Guizhou Miao population, and therefore would be a useful tool in forensic identification and male parentage testing and even pedigree investigation.
DOI: 10.6084/m9.figshare.7082681
title: Pathological missorting of endogenous MAPT/Tau in neurons caused by failure of protein degradation systems

description: Missorting of MAPT/Tau represents one of the early signs of neurodegeneration in Alzheimer disease. The triggers for this are still a matter of debate. Here we investigated the sorting mechanisms of endogenous MAPT in mature primary neurons using microfluidic chambers (MFCs) where cell compartments can be observed separately. Blocking protein degradation pathways with proteasomal or autophagy inhibitors dramatically increased the missorting of MAPT in dendrites on the neuritic side, suggesting that degradation of MAPT in dendrites is a major determinant for the physiological axonal distribution of MAPT. Such missorted dendritic MAPT differed in its phosphorylation pattern from axonal MAPT. By contrast, enhancing autophagy or proteasomal pathways strongly reduced MAPT missorting, thereby confirming the role of protein degradation pathways in the polar distribution of MAPT. Dendritic missorting of MAPT by blocking protein degradation resulted in the loss of spines but not in overall cell toxicity. Inhibition of local protein synthesis in dendrites eliminated the missorting of MAPT, indicating that the accumulation of dendritic MAPT is locally generated. In support of this, a substantial fraction of <i>Mapt/Tau</i> mRNA was detected in dendrites. Taken together, our results indicate that the autophagy and proteasomal pathways play important roles in fine-tuning dendritic MAPT levels and thereby prevent synaptic toxicity caused by MAPT accumulation. <b>Abbreviations</b> Ani: anisomycin; Baf: bafilomycin A<sub>1</sub>; BSA: bovine serum albumin; cAMP: cyclic adenosine monophosphate; CHX: cycloheximide; DMSO: dimethyl sulfoxide; DIV: days in vitro; Epo: epoxomicin; E18: embryonic day 18; FISH: fluorescence in situ hybridization; IgG: immunoglobulin; kDa: kilodalton; Lac: lactacystin; LDH: lactate dehydrogenase; MFC: microfluidic chambers; MAPs: microtubule-associated proteins; MAPT/Tau: microtubule-associated protein tau; PVDF: polyvinylidene difluoride; PBS: phosphate-buffered saline; PRKA: protein kinase AMP-activated; RD150: round device 150; RT: room temperature; SDS: sodium dodecyl sulfate; SEM: standard error of the mean; Wor: wortmannin.
DOI: 10.6084/m9.figshare.12849821
title: Genetic structure and forensic characterisation of 36 Y-chromosomal STR loci in Hmong-Mien-speaking Miao population

description: Y-chromosomal short tandem repeats (Y-STRs) are widely used in paternity identification, pedigree investigation, and human population genetic history. To investigate the Y-STR polymorphisms in a typical Miao population, and explore the genetic differentiation between the Miao population and reference groups. We detected 36 Y-STRs genotyping in 455 unrelated Miao individuals from Guizhou province, and analysed genetic differentiation between the Miao population and 76 reference groups. A total of 369 alleles were obtained, and the allele frequencies ranged from 0.0022 to 0.9802. In addition, the haplotype diversity, random match probability, and discrimination capacity values were 0.99997, 0.0022, and 0.9934, respectively. Moreover, the genetic relationships between Guizhou Miao and 76 ethnic populations showed that the population stratification was almost consistent with geographic distribution and language-family. The 36 Y-STR loci in this study have good polymorphism distributions in the Guizhou Miao population, and therefore would be a useful tool in forensic identification and male parentage testing and even pedigree investigation.
DOI: 10.6084/m9.figshare.7082681.v1
title: Pathological missorting of endogenous MAPT/Tau in neurons caused by failure of protein degradation systems

description: Missorting of MAPT/Tau represents one of the early signs of neurodegeneration in Alzheimer disease. The triggers for this are still a matter of debate. Here we investigated the sorting mechanisms of endogenous MAPT in mature primary neurons using microfluidic chambers (MFCs) where cell compartments can be observed separately. Blocking protein degradation pathways with proteasomal or autophagy inhibitors dramatically increased the missorting of MAPT in dendrites on the neuritic side, suggesting that degradation of MAPT in dendrites is a major determinant for the physiological axonal distribution of MAPT. Such missorted dendritic MAPT differed in its phosphorylation pattern from axonal MAPT. By contrast, enhancing autophagy or proteasomal pathways strongly reduced MAPT missorting, thereby confirming the role of protein degradation pathways in the polar distribution of MAPT. Dendritic missorting of MAPT by blocking protein degradation resulted in the loss of spines but not in overall cell toxicity. Inhibition of local protein synthesis in dendrites eliminated the missorting of MAPT, indicating that the accumulation of dendritic MAPT is locally generated. In support of this, a substantial fraction of <i>Mapt/Tau</i> mRNA was detected in dendrites. Taken together, our results indicate that the autophagy and proteasomal pathways play important roles in fine-tuning dendritic MAPT levels and thereby prevent synaptic toxicity caused by MAPT accumulation. <b>Abbreviations</b> Ani: anisomycin; Baf: bafilomycin A<sub>1</sub>; BSA: bovine serum albumin; cAMP: cyclic adenosine monophosphate; CHX: cycloheximide; DMSO: dimethyl sulfoxide; DIV: days in vitro; Epo: epoxomicin; E18: embryonic day 18; FISH: fluorescence in situ hybridization; IgG: immunoglobulin; kDa: kilodalton; Lac: lactacystin; LDH: lactate dehydrogenase; MFC: microfluidic chambers; MAPs: microtubule-associated proteins; MAPT/Tau: microtubule-associated protein tau; PVDF: polyvinylidene difluoride; PBS: phosphate-buffered saline; PRKA: protein kinase AMP-activated; RD150: round device 150; RT: room temperature; SDS: sodium dodecyl sulfate; SEM: standard error of the mean; Wor: wortmannin.
DOI: 10.6084/m9.figshare.22811343.v1
title: Complete chloroplast genome features and phylogenetic analysis of <i>Abies ernestii</i> var. <i>salouenensis</i> (Bordères and Gaussen) W. C. Cheng and L. K. Fu from southwest China

description: <i>Abies ernestii</i> var. <i>salouenensis</i> (Bordères & Gaussen) W. C. Cheng & L. K. Fu is endemic to southwest China, including the southeastern Tibetan Plateau and the northwestern Yunnan Province. The taxonomic relationships between <i>A. ernestii var. salouenensis</i> and two other closely related fir species (<i>A. chensiensis</i> Tiegh. and <i>A. ernestii</i> Rehd.) still need to be determined. Here, we report for the first time the whole chloroplast genome of <i>A. ernestii</i> var. <i>salouenensis</i>. Its genome is 121,759 bp long and is characterized by a circular structure with 68 peptide-encoding genes, 16 tRNAs, six ORFs, and four rRNAs. We also identified 70 microsatellite repeat sequences and 14 tandem repeat sequences in the chloroplast genome of <i>A. ernestii</i> var. <i>salouenensis</i>. Comparative genome analysis indicated considerable variation in <i>ycf</i>1 and <i>ycf</i>2. Phylogenetic analysis supported the monophyly of <i>A. ernestii</i> var. <i>salouenensis</i>, <i>A. chensiensis</i> Tiegh., and <i>A. ernestii</i> Rehd. The relationships among them should be surveyed using more samples at the species level. This study will facilitate taxonomic studies and the development of suitable chloroplast markers for fir species.
DOI: 10.6084/m9.figshare.22811343
title: Complete chloroplast genome features and phylogenetic analysis of <i>Abies ernestii</i> var. <i>salouenensis</i> (Bordères and Gaussen) W. C. Cheng and L. K. Fu from southwest China

description: <i>Abies ernestii</i> var. <i>salouenensis</i> (Bordères & Gaussen) W. C. Cheng & L. K. Fu is endemic to southwest China, including the southeastern Tibetan Plateau and the northwestern Yunnan Province. The taxonomic relationships between <i>A. ernestii var. salouenensis</i> and two other closely related fir species (<i>A. chensiensis</i> Tiegh. and <i>A. ernestii</i> Rehd.) still need to be determined. Here, we report for the first time the whole chloroplast genome of <i>A. ernestii</i> var. <i>salouenensis</i>. Its genome is 121,759 bp long and is characterized by a circular structure with 68 peptide-encoding genes, 16 tRNAs, six ORFs, and four rRNAs. We also identified 70 microsatellite repeat sequences and 14 tandem repeat sequences in the chloroplast genome of <i>A. ernestii</i> var. <i>salouenensis</i>. Comparative genome analysis indicated considerable variation in <i>ycf</i>1 and <i>ycf</i>2. Phylogenetic analysis supported the monophyly of <i>A. ernestii</i> var. <i>salouenensis</i>, <i>A. chensiensis</i> Tiegh., and <i>A. ernestii</i> Rehd. The relationships among them should be surveyed using more samples at the species level. This study will facilitate taxonomic studies and the development of suitable chloroplast markers for fir species.
DOI: 10.6084/m9.figshare.12850004
title: Clinical and molecular characteristics associated with survival among cancer patients receiving first-line anti-PD-1/PD-L1-based therapies

description: Anti-PD-1/PD-L1-based therapy has emerged recently, and we aimed to figure out the latent value of different clinical and molecular factors to predict the efficacy of immune checkpoint inhibitors (ICIs) therapy compared with non-immunotherapy in the first-line setting. We assessed the clinical outcomes of 8711 patients in 13 trials receiving anti-PD-1/PD-L1-based therapy or non-immunotherapy as first-line treatment, and different predictors were investigated. Overall, compared with non-immunotherapy, anti-PD-1/PD-L1-based therapy reduced the risk of death by 31% (HR 0.69, 95%CI: 0.60–0.79) for all cancers. Stratified analysis showed that the progression-free survival (PFS) benefit from anti-PD-1/PD-L1-based therapy existed in all three PD-L1 status subgroups (tumour proportion score, TPS ≥50%: HR 0.54, 95%CI: 0.38–0.78; TPS 1–49%: HR 0.56, 95%CI: 0.46–0.68; TPS &lt;1%: HR 0.82, 95%CI: 0.73–0.91; interaction, <i>p</i> &lt; 0.01). ICI therapy also prolonged PFS in males (HR 0.64, 95%CI: 0.50–0.83) and younger patients (HR 0.70, 95%CI: 0.52–0.93), and they might prolong overall survival (OS) in patients without brain metastasis (HR 0.54, 95%CI: 0.41–0.71). PD-L1 expression level alone is imperfect to predict the efficacy of anti-PD-1/PD-L1-based therapies as first-line cancer treatment. Meanwhile, sex, age, and status of brain metastases might also be predictive parameters for the selection of cancer patients.
DOI: 10.6084/m9.figshare.12870326
title: Additional file 11 of Development of simultaneous interaction prediction approach (SiPA) for the expansion of interaction network of traditional Chinese medicine

description: Additional file 11: Table S11. Compound-target interactions predicted based on compound-target correlation space based interaction prediction model.
DOI: 10.6084/m9.figshare.12870326.v1
title: Additional file 11 of Development of simultaneous interaction prediction approach (SiPA) for the expansion of interaction network of traditional Chinese medicine

description: Additional file 11: Table S11. Compound-target interactions predicted based on compound-target correlation space based interaction prediction model.
DOI: 10.6084/m9.figshare.12870332
title: Additional file 1 of Development of simultaneous interaction prediction approach (SiPA) for the expansion of interaction network of traditional Chinese medicine

description: Additional file 1: Table S1. Compounds in compound Salvia miltiorrhiza.
DOI: 10.6084/m9.figshare.12870323.v1
title: Additional file 10 of Development of simultaneous interaction prediction approach (SiPA) for the expansion of interaction network of traditional Chinese medicine

description: Additional file 10: Table S10. Compound-target interactions predicted based on simple inference model.
DOI: 10.6084/m9.figshare.12870332.v1
title: Additional file 1 of Development of simultaneous interaction prediction approach (SiPA) for the expansion of interaction network of traditional Chinese medicine

description: Additional file 1: Table S1. Compounds in compound Salvia miltiorrhiza.
DOI: 10.6084/m9.figshare.12870335
title: Additional file 2 of Development of simultaneous interaction prediction approach (SiPA) for the expansion of interaction network of traditional Chinese medicine

description: Additional file 2: Table S2. Targets (Proteins) related to compound Salvia miltiorrhiza.
DOI: 10.6084/m9.figshare.12870323
title: Additional file 10 of Development of simultaneous interaction prediction approach (SiPA) for the expansion of interaction network of traditional Chinese medicine

description: Additional file 10: Table S10. Compound-target interactions predicted based on simple inference model.
DOI: 10.6084/m9.figshare.12870335.v1
title: Additional file 2 of Development of simultaneous interaction prediction approach (SiPA) for the expansion of interaction network of traditional Chinese medicine

description: Additional file 2: Table S2. Targets (Proteins) related to compound Salvia miltiorrhiza.
DOI: 10.6084/m9.figshare.12870338
title: Additional file 3 of Development of simultaneous interaction prediction approach (SiPA) for the expansion of interaction network of traditional Chinese medicine

description: Additional file 3: Table S3. Cardiovascular diseases related to compound Salvia miltiorrhiza.
DOI: 10.6084/m9.figshare.12870338.v1
title: Additional file 3 of Development of simultaneous interaction prediction approach (SiPA) for the expansion of interaction network of traditional Chinese medicine

description: Additional file 3: Table S3. Cardiovascular diseases related to compound Salvia miltiorrhiza.
DOI: 10.22008/fk2/b674ar/6g67tt
title: r_TOA_04.tif

description: SICE version: Cloud removed, PPGC, SNAP7
DOI: 10.22008/fk2/b674ar/lj0myh
title: r_TOA_05.tif

description: SICE version: Cloud removed, PPGC, SNAP7
DOI: 10.22008/fk2/b674ar/mujtb1
title: r_TOA_06.tif

description: SICE version: Cloud removed, PPGC, SNAP7
DOI: 10.22008/fk2/b674ar/ajx2ox
title: r_TOA_07.tif

description: SICE version: Cloud removed, PPGC, SNAP7
DOI: 10.22008/fk2/b674ar/mrs4w6
title: r_TOA_08.tif

description: SICE version: Cloud removed, PPGC, SNAP7
DOI: 10.22008/fk2/b674ar/aij5oa
title: r_TOA_09.tif

description: SICE version: Cloud removed, PPGC, SNAP7
DOI: 10.22008/fk2/b674ar/jyp7zm
title: r_TOA_10.tif

description: SICE version: Cloud removed, PPGC, SNAP7
DOI: 10.22008/fk2/b674ar/6mg50j
title: r_TOA_11.tif

description: SICE version: Cloud removed, PPGC, SNAP7
DOI: 10.22008/fk2/b674ar/ffgfeb
title: r_TOA_12.tif

description: SICE version: Cloud removed, PPGC, SNAP7