DOI: 10.5061/dryad.9s4mw6mn1
title: A cost-effectiveness analysis of second-generation antihistamine 1 receptor blockers and Japanese kampo shoseiryuto for treatment of perennial allergic rhinitis in outpatient settings in Japan

description: Objectives: Perennial allergic rhinitis (PAR) is common in Japan.
 Second-generation antihistamines (SGAs) are commonly used for its
 treatment; however, it remains unclear which SGA is the most
 cost-effective. Additionally, the pharmacoeconomics of Japanese Kampo
 shoseiryuto (which was traditionally prescribed to treat PAR in Japan)
 remains poorly understood. In this study, we aimed to investigate the
 effectiveness of various SGAs and shoseiryuto for the treatment of PAR in
 Japanese outpatients, from the healthcare payer’s perspective. Methods:
 The most cost- and clinically effective SGAs were determined from a list
 of six SGAs (bepotastine, 10 mg; cetirizine, 10 mg; ebastine, 10 mg;
 epinastine, 20 mg; loratadine, 10 mg; and olopatadine, 5 mg) together with
 shoseiryuto, using the overall improvement rate through a model-based
 analysis. The time horizon was 28 days. Costs were determined based on the
 Medical Fee Index in 2020. Deterministic and probabilistic sensitivity
 analyses were conducted to address the uncertainty of the base-case
 results. Results:
              Overall, bepotastine (10 mg) and ebastine (10 mg) were cost-effective. Shoseiryuto was less cost-effective than ebastine (10 mg) (dominated). Ebastine (10 mg) was the most cost-effective option based on deterministic and probabilistic sensitivity analyses. Conclusions: Ebastine (10 mg) was the most cost-effective treatment strategy for PAR among the agents evaluated in this study. This insight could aid in establishing an appropriate formulary for treating PAR in hospitals and communities.
description: # Title of Dataset: A Cost-Utility Analysis of Oral Triptans for Migraine
 in an Adult Outpatient Setting in Japan --- Author(s) Naoto Nakagawa,
 Phar.D., Ph.D. School of Pharmaceutical Sciences, Ohu University,
 Koriyama, Fukushima, Japan 31-1 Misumido, Tomita-machi, Koriyama,
 Fukushima 963-8611, Japan Email:
 [n-nakagawa@pha.ohu-u.ac.jp](mailto:n-nakagawa@pha.ohu-u.ac.jp) Masami
 Kashiwabara, B.S., R. Ph, Qol Holdings Co., Ltd. Email:
 [m-kashiwabara@qol-net.co.jp](mailto:m-kashiwabara@qol-net.co.jp) Kei
 Egawa, B.S. School of Pharmaceutical Sciences, Ohu University, Koriyama,
 Fukushima, Japan 31-1 Misumido, Tomita-machi, Koriyama, Fukushima
 963-8611, Japan Email: [716008@ohu-u.jp](mailto:716008@ohu-u.jp) Ayaka
 Sasaki, B.S., R. Ph. School of Pharmaceutical Sciences, Ohu University,
 Koriyama, Fukushima, Japan 31-1 Misumido, Tomita-machi, Koriyama,
 Fukushima 963-8611, Japan Email: [717045@ohu-u.jp](mailto:717045@ohu-u.jp)
 **File list** \_Input data Parameters for sensitivity analyses **File
 descriptions** Details for:_Input data The file is a table to analyze for
 input with TreeAge Pro. Updated information is that drug prices were
 changed with two times multipling because because relevant articles to
 which I reffered in my manuscript set 28 days for treatment trial.
 Format(s): .csv Dimensions: 28 rows x 5 columns Variables: *Name: c_XXX
 means cost variables (unit is 'yen'), p_XXX means probability
 variables, and u_XXX means utility variables (unit is 'QALY').
 *Description: definition of each variable. *Root Definition: individual
 variables for a base-case scenario. *Low and High columns: the low and the
 high numbers for one-way sensitivity analysis. Details for: Parameters for
 sensitivity analyses Format(s): .csv Dimensions:28 rows x 7 columns
 Variables: * Parameter: identified parameters for sensitivity analysis *
 Base case value: individual variables for a base-case scenario. * Lower
 Limits: the low numbers for one-way sensitivity analysis. * Higher Limits:
 the high numbers for one-way sensitivity analysis. * Distribution: a type
 of distribution for probabilistic sensitivity analysis * Distribution
 parameters: individual variables for probabilistic sensitivity analysis,
 the symbol "-" means "Not applicable". * Reference
 number: listed number derived from articles, "NA" means nothing
 to be refered to corresponding parameters.