cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.1265149.v1
title: Dental Morphology of <i>Vintana Sertichi</i> (Mammalia, Gondwanatheria) from the Late Cretaceous of Madagascar

description: ABSTRACT—The cranium of <i>Vintana sertichi</i> preserves the first associated upper dentition of a gondwanatherian mammal. Gondwanatherians are known almost exclusively from isolated teeth, particularly molariforms. As such, referral of <i>V. sertichi</i> to the Gondwanatheria, differentiation of <i>V. sertichi</i> from other gondwanatherians, and determination of the relationships of <i>V. sertichi</i> to other gondwanatherians must rely heavily on dental morphology. The hypsodont nature, gross morphology, enamel microstructure, and wear pattern of its molariform teeth serve to unequivocally identify the cranium of <i>V. sertichi</i> as that of a sudamericid gondwanatherian. Based on available morphology, <i>V. sertichi</i> appears to have had an upper dental formula of 2.0.1.4. There are two long, curved alveoli in each premaxilla for enlarged, buccolingually compressed, procumbent incisors that were well separated from the cheek teeth by a long diastema. There is no evidence of a canine. The single premolariform tooth appears to have been small and two-rooted, but neither the left nor the right crowns are preserved. Of the eight upper molariform alveoli, four are preserved with teeth in situ, three in the left maxilla (antepenultimate, penultimate, and ultimate) and one in the right (penultimate). The molariform cheek teeth have several salient characteristics: large size, hypsodont crowns, roughly quadrangular outlines, occlusal surfaces worn essentially flat, numerous cementum-filled infundibula, cementum-filled furrows that invaginate from the buccal side but do not extend to the base of the crown, and multiple, short root apices. The relative amounts of wear on the molariform cheek teeth of <i>V. sertichi</i> indicate a mesial-to-distal eruption sequence.SUPPLEMENTAL DATA—Supplemental materials are available for this article for free at www.tandfonline.com/UJVP
DOI: 10.6084/m9.figshare.1279394.v291
title: Germline encoded anti-A-reactive IgM arising from growth-dependent and aberrant O-GalNAc glycosylations.*

description: While <i>O</i>-linked GalNAc glycosylated structures do not occur in plants, the germline encoding of an anti-A-reactive immunoglobulin M (IgM) molecule that is complementary to mammalian <i>O</i>-GalNAc glycan-bearing ovarian glycolipids, was experimentally documented in C57BL/10 mice. This anti-A antibody, which does not appear in animals subjected to an ovariectomy prior to the onset of puberty, appears serologically identical to the human innate anti-A isoagglutinin. The target of this antibody is a trans-species developmental antigen that signifies malignancy when accumulating in non-developmental tissues. In mouse and man, this molecule most likely gets its complementary footprints from the early growth-dependent, trans-species <i>O</i>-GalNAc glycosylation of proteins and subsequent GalNAc transferase depletion that completes the cell differentiation processes and results in release of complementary protein(s) involving the secretory IgM, which might establish this mechanism through expression of germline-specific serine residues and reveals the structure of the volatilely expressed, “lost” glycan. These early or first <i>O</i>-GalNAc-glycosylations of proteins appear metabolically related to those of the mucin-type, “aberrant” monosaccharide GalNAcα1-<i>O</i>-Ser/Thr-R or Tn antigen and explain the anti-Tn cross-reactivity of anti-A specific immunoglobulins and pronounced occurrence of cross-reactive anti-Tn antibody in the plasma of human histo (blood) group O. In fact, in the human blood group O, an A-allelic, phenotype-specific GalNAc glycosylation of plasma proteins does not occur and affect the levels of the anti-Tn antibody, which may function as a growth regulator that depending on its levels, initiates the process of growth inhibition through enzyme-substrate competition with subsequent trans-species <i>O</i>-GalNAc-glycosylations and mediates autologous cellular cytotoxicity.
DOI: 10.6084/m9.figshare.1265146
title: Sensory Anatomy and Sensory Ecology of <i>Vintana Sertichi</i> (Mammalia, Gondwanatheria) from the Late Cretaceous of Madagascar

description: ABSTRACT—Living mammals are distinguished from other extant tetrapods by adaptations for improved senses of hearing, touch, and smell. These adaptations, and concomitant reductions in visual anatomy, evolved during the Mesozoic in the mammalian and therian stem lineages. Here, we present a comparative study of the sensory anatomy of the Late Cretaceous gondwanatherian mammaliaform <i>Vintana sertichi</i> in order to draw inferences regarding its sensory abilities and sensory ecology. Our analyses demonstrate that <i>Vintana</i> has relatively large orbits that may have accommodated large eyes. <i>Vintana</i> also possessed cochlear primary and secondary osseous laminae and a cochlear canal that was relatively longer than in non-mammaliaform cynodonts but shorter than in extant therians. These features suggest that <i>Vintana</i> had some capacity for high-frequency hearing (i.e., &gt;20 kHz), but that its cochlea may have encoded a more limited range of frequencies than the cochleas of most extant therians. The semicircular canals of <i>Vintana</i> have large radii of curvature and are nearly orthogonal, suggesting high sensitivity to angular head accelerations. These vestibular features may have evolved in order to stabilize large eyes during rapid and/or agile locomotion. Combined with evidence for large olfactory bulbs and a large trigeminal endocast, these data reveal that <i>Vintana</i> possessed a unique suite of sensory adaptations that distinguish it from other Mesozoic mammaliaforms. If these inferences are correct, then <i>Vintana</i> was probably a large-eyed and agile species, with a keen sense of smell and better high-frequency hearing than most other Mesozoic mammaliaforms.SUPPLEMENTAL DATA—Supplemental materials are available for this article for free at www.tandfonline.com/UJVP
DOI: 10.6084/m9.figshare.1265147
title: Endocranial and Inner Ear Morphology of <i>Vintana Sertichi</i> (Mammalia, Gondwanatheria) from the Late Cretaceous of Madagascar

description: ABSTRACTWe present the first digital reconstruction of the endocranial cavity and endosseous labyrinth of the Late Cretaceous gondwanatherian mammal <i>Vintana sertichi</i> from the Maevarano Formation of Madagascar. The Malagasy specimen is exceptionally well preserved and represents the only described cranium known for Gondwanatheria, an enigmatic clade from the Late Cretaceous and Paleogene of Gondwana. The endocranial cast of <i>Vintana</i> is relatively small for an animal of its estimated body mass. Its encephalization quotient is 0.28–0.56 for a range of body mass estimates, which is similar to that of basal mammaliaforms. The olfactory bulbs are very large, occupying over 14% of the endocranial volume. The cerebral hemispheres are only slightly expanded, more similar to the condition in <i>Morganucodon</i> than to that in multituberculates and monotremes. Unlike the condition in other Mesozoic mammaliaforms, the endocast is greatly flexed at the circular fissure. The osseous labyrinth displays a mixture of derived and primitive features. The cochlear canal is only slightly curved and short compared with that of extant therians. The ratio between total cochlear canal length and maximum cranial length is smaller than in basal mammaliaforms and approximates that of non-mammaliaform cynodonts. By contrast, the presence of both primary and secondary osseous laminae, the tractus foraminosus, and Rosenthal's canal represent derived characteristics of the mammalian inner ear typical of cladotherians. A modern innervation of the cochlea has either evolved independently in <i>Vintana</i> and cladotherians or was already present in the last common ancestor of both clades.SUPPLEMENTAL DATA—Supplemental materials are available for this article for free at www.tandfonline.com/UJVP
DOI: 10.6084/m9.figshare.1265148.v1
title: Craniofacial Morphology of <i>Vintana Sertichi</i> (Mammalia, Gondwanatheria) from the Late Cretaceous of Madagascar

description: ABSTRACTThe Gondwanatheria are an enigmatic clade of Cretaceous and Paleogene mammals known from South America, Africa, Madagascar, India, and the Antarctic Peninsula. The eight valid species—each belonging to a monotypic genus and the first of which was described only 30 years ago—are represented almost exclusively by isolated teeth, in addition to fragmentary dentaries attributed to <i>Sudamerica</i>, <i>Gondwanatherium</i>, <i>Ferugliotherium</i>, and an unnamed taxon from Tanzania. No cranial (skull exclusive of lower jaw) or postcranial material has heretofore been assigned to the Gondwanatheria, a severe limitation that has precluded a comprehensive assessment of phylogenetic affinities. Here we describe, in detail, the first cranial specimen of a gondwanatherian mammal. This material consists of a complete and well-preserved cranium of the sudamericid <i>Vintana sertichi</i>, recovered from the Upper Cretaceous (Maastrichtian) Maevarano Formation in the Mahajanga Basin of northwestern Madagascar. Salient features of the cranium include elongate, scimitar-like jugal flanges, huge orbits, strong klinorhynchy, and a vaulted nuchal region. Micro-computed tomography greatly facilitated the delineation of sutures and the description of internal morphology. The cranial features of <i>Vintana</i> are compared with those of a broad range of synapsids, with particular concentration on other Mesozoic mammaliaforms. The cranium of <i>Vintana</i> exhibits a mosaic of extremely primitive and extremely derived features. It is the second largest known for a Mesozoic mammaliaform, superseded only by that of the eutriconodontan <i>Repenomamus giganticus</i> from the Early Cretaceous of China. <i>Vintana</i> is the largest known Late Cretaceous mammaliaform; it is also the largest known Mesozoic mammaliaform from Gondwana.SUPPLEMENTAL DATA—Supplemental materials are available for this article for free at www.tandfonline.com/UJVP
DOI: 10.6084/m9.figshare.1265143
title: CMG webpage figures

description: Figures from my computational modelling group page relating to MHC class I antigen processing.
DOI: 10.6084/m9.figshare.1279394.v292
title: Germline encoded anti-A-reactive IgM arising from growth-dependent and aberrant O-GalNAc glycosylations.*

description: While <i>O</i>-linked GalNAc-glycosylated structures do not occur in plants, the germline encoding of an anti-A-reactive immunoglobulin M (IgM) molecule that is complementary to mammalian <i>O</i>-GalNAc glycan-bearing ovarian glycolipids, was experimentally documented in C57BL/10 mice. This anti-A antibody, which does not appear in animals subjected to an ovariectomy prior to the onset of puberty, appears serologically identical to the human innate anti-A isoagglutinin. The target of this antibody is a trans-species developmental antigen that signifies malignancy when accumulating in non-developmental tissues. In mouse and man, this molecule most likely gets its complementary footprints from the early growth-dependent, trans-species <i>O</i>-GalNAc glycosylation of proteins and subsequent GalNAc transferase depletion that completes the cell differentiation processes and results in release of complementary protein(s) involving the secretory IgM, which might establish this mechanism through expression of germline-specific serine residues and reveals the structure of the volatilely expressed, “lost” glycan. These early or first <i>O</i>-GalNAc-glycosylations of proteins appear metabolically related to those of the mucin-type, “aberrant” monosaccharide GalNAcα1-<i>O</i>-Ser/Thr-R or Tn antigen and explain the anti-Tn cross-reactivity of anti-A-specific immunoglobulins and pronounced occurrence of cross-reactive anti-Tn antibody in the plasma of human histo (blood) group O. In fact, in the human blood group O, an A-allelic, phenotype-specific GalNAc glycosylation of plasma proteins does not occur and affect the levels of the anti-Tn antibody, which may function as a growth regulator that depending on its levels, initiates the process of growth inhibition through enzyme-substrate competition with subsequent trans-species <i>O</i>-GalNAc-glycosylations and mediates autologous cellular cytotoxicity.
DOI: 10.6084/m9.figshare.1265146.v2
title: Sensory Anatomy and Sensory Ecology of <i>Vintana Sertichi</i> (Mammalia, Gondwanatheria) from the Late Cretaceous of Madagascar

description: ABSTRACT—Living mammals are distinguished from other extant tetrapods by adaptations for improved senses of hearing, touch, and smell. These adaptations, and concomitant reductions in visual anatomy, evolved during the Mesozoic in the mammalian and therian stem lineages. Here, we present a comparative study of the sensory anatomy of the Late Cretaceous gondwanatherian mammaliaform <i>Vintana sertichi</i> in order to draw inferences regarding its sensory abilities and sensory ecology. Our analyses demonstrate that <i>Vintana</i> has relatively large orbits that may have accommodated large eyes. <i>Vintana</i> also possessed cochlear primary and secondary osseous laminae and a cochlear canal that was relatively longer than in non-mammaliaform cynodonts but shorter than in extant therians. These features suggest that <i>Vintana</i> had some capacity for high-frequency hearing (i.e., &gt;20 kHz), but that its cochlea may have encoded a more limited range of frequencies than the cochleas of most extant therians. The semicircular canals of <i>Vintana</i> have large radii of curvature and are nearly orthogonal, suggesting high sensitivity to angular head accelerations. These vestibular features may have evolved in order to stabilize large eyes during rapid and/or agile locomotion. Combined with evidence for large olfactory bulbs and a large trigeminal endocast, these data reveal that <i>Vintana</i> possessed a unique suite of sensory adaptations that distinguish it from other Mesozoic mammaliaforms. If these inferences are correct, then <i>Vintana</i> was probably a large-eyed and agile species, with a keen sense of smell and better high-frequency hearing than most other Mesozoic mammaliaforms.SUPPLEMENTAL DATA—Supplemental materials are available for this article for free at www.tandfonline.com/UJVP
DOI: 10.6084/m9.figshare.1265146.v1
title: Sensory Anatomy and Sensory Ecology of <i>Vintana Sertichi</i> (Mammalia, Gondwanatheria) from the Late Cretaceous of Madagascar

description: ABSTRACT—Living mammals are distinguished from other extant tetrapods by adaptations for improved senses of hearing, touch, and smell. These adaptations, and concomitant reductions in visual anatomy, evolved during the Mesozoic in the mammalian and therian stem lineages. Here, we present a comparative study of the sensory anatomy of the Late Cretaceous gondwanatherian mammaliaform <i>Vintana sertichi</i> in order to draw inferences regarding its sensory abilities and sensory ecology. Our analyses demonstrate that <i>Vintana</i> has relatively large orbits that may have accommodated large eyes. <i>Vintana</i> also possessed cochlear primary and secondary osseous laminae and a cochlear canal that was relatively longer than in non-mammaliaform cynodonts but shorter than in extant therians. These features suggest that <i>Vintana</i> had some capacity for high-frequency hearing (i.e., &gt;20 kHz), but that its cochlea may have encoded a more limited range of frequencies than the cochleas of most extant therians. The semicircular canals of <i>Vintana</i> have large radii of curvature and are nearly orthogonal, suggesting high sensitivity to angular head accelerations. These vestibular features may have evolved in order to stabilize large eyes during rapid and/or agile locomotion. Combined with evidence for large olfactory bulbs and a large trigeminal endocast, these data reveal that <i>Vintana</i> possessed a unique suite of sensory adaptations that distinguish it from other Mesozoic mammaliaforms. If these inferences are correct, then <i>Vintana</i> was probably a large-eyed and agile species, with a keen sense of smell and better high-frequency hearing than most other Mesozoic mammaliaforms.SUPPLEMENTAL DATA—Supplemental materials are available for this article for free at www.tandfonline.com/UJVP
DOI: 10.6084/m9.figshare.1265147.v2
title: Endocranial and Inner Ear Morphology of <i>Vintana Sertichi</i> (Mammalia, Gondwanatheria) from the Late Cretaceous of Madagascar

description: ABSTRACTWe present the first digital reconstruction of the endocranial cavity and endosseous labyrinth of the Late Cretaceous gondwanatherian mammal <i>Vintana sertichi</i> from the Maevarano Formation of Madagascar. The Malagasy specimen is exceptionally well preserved and represents the only described cranium known for Gondwanatheria, an enigmatic clade from the Late Cretaceous and Paleogene of Gondwana. The endocranial cast of <i>Vintana</i> is relatively small for an animal of its estimated body mass. Its encephalization quotient is 0.28–0.56 for a range of body mass estimates, which is similar to that of basal mammaliaforms. The olfactory bulbs are very large, occupying over 14% of the endocranial volume. The cerebral hemispheres are only slightly expanded, more similar to the condition in <i>Morganucodon</i> than to that in multituberculates and monotremes. Unlike the condition in other Mesozoic mammaliaforms, the endocast is greatly flexed at the circular fissure. The osseous labyrinth displays a mixture of derived and primitive features. The cochlear canal is only slightly curved and short compared with that of extant therians. The ratio between total cochlear canal length and maximum cranial length is smaller than in basal mammaliaforms and approximates that of non-mammaliaform cynodonts. By contrast, the presence of both primary and secondary osseous laminae, the tractus foraminosus, and Rosenthal's canal represent derived characteristics of the mammalian inner ear typical of cladotherians. A modern innervation of the cochlea has either evolved independently in <i>Vintana</i> and cladotherians or was already present in the last common ancestor of both clades.SUPPLEMENTAL DATA—Supplemental materials are available for this article for free at www.tandfonline.com/UJVP
DOI: 10.6084/m9.figshare.1279394.v293
title: Germline encoded anti-A-reactive IgM arising from growth-dependent and aberrant O-GalNAc glycosylations.*

description: While <i>O</i>-linked GalNAc-glycosylated structures do not occur in plants, the germline encoding of an anti-A-reactive immunoglobulin M (IgM) molecule that is complementary to mammalian <i>O</i>-GalNAc glycan-bearing ovarian glycolipids, was experimentally documented in C57BL/10 mice. This anti-A antibody, which does not appear in animals subjected to an ovariectomy prior to the onset of puberty, appears serologically identical to the human innate anti-A isoagglutinin. The target of this antibody is a trans-species developmental antigen that signifies malignancy when accumulating in non-developmental tissues. In mouse and man, this molecule most likely gets its complementary footprints from the early growth-dependent, trans-species <i>O</i>-GalNAc glycosylation of proteins and subsequent GalNAc transferase depletion that completes the cell differentiation processes and results in release of complementary protein(s) involving the secretory IgM, which might establish this mechanism through expression of germline-specific serine residues and reveals the structure of the volatilely expressed, “lost” glycan. These early or first <i>O</i>-GalNAc-glycosylations of proteins appear metabolically related to those of the mucin-type, “aberrant” monosaccharide GalNAcα1-<i>O</i>-Ser/Thr-R or Tn antigen and explain the anti-Tn cross-reactivity of anti-A-specific immunoglobulins and pronounced occurrence of cross-reactive anti-Tn antibody in the plasma of human histo (blood) group O. In fact, in the human blood group O, an A-allelic, phenotype-specific GalNAc glycosylation of plasma proteins does not occur and affect the levels of the anti-Tn antibody, which may function as a growth regulator that depending on its levels, initiates the process of growth inhibition through enzyme-substrate competition with subsequent trans-species <i>O</i>-GalNAc-glycosylations and mediates autologous cellular cytotoxicity.
DOI: 10.6084/m9.figshare.1265147.v1
title: Endocranial and Inner Ear Morphology of <i>Vintana Sertichi</i> (Mammalia, Gondwanatheria) from the Late Cretaceous of Madagascar

description: ABSTRACTWe present the first digital reconstruction of the endocranial cavity and endosseous labyrinth of the Late Cretaceous gondwanatherian mammal <i>Vintana sertichi</i> from the Maevarano Formation of Madagascar. The Malagasy specimen is exceptionally well preserved and represents the only described cranium known for Gondwanatheria, an enigmatic clade from the Late Cretaceous and Paleogene of Gondwana. The endocranial cast of <i>Vintana</i> is relatively small for an animal of its estimated body mass. Its encephalization quotient is 0.28–0.56 for a range of body mass estimates, which is similar to that of basal mammaliaforms. The olfactory bulbs are very large, occupying over 14% of the endocranial volume. The cerebral hemispheres are only slightly expanded, more similar to the condition in <i>Morganucodon</i> than to that in multituberculates and monotremes. Unlike the condition in other Mesozoic mammaliaforms, the endocast is greatly flexed at the circular fissure. The osseous labyrinth displays a mixture of derived and primitive features. The cochlear canal is only slightly curved and short compared with that of extant therians. The ratio between total cochlear canal length and maximum cranial length is smaller than in basal mammaliaforms and approximates that of non-mammaliaform cynodonts. By contrast, the presence of both primary and secondary osseous laminae, the tractus foraminosus, and Rosenthal's canal represent derived characteristics of the mammalian inner ear typical of cladotherians. A modern innervation of the cochlea has either evolved independently in <i>Vintana</i> and cladotherians or was already present in the last common ancestor of both clades.SUPPLEMENTAL DATA—Supplemental materials are available for this article for free at www.tandfonline.com/UJVP
DOI: 10.6084/m9.figshare.1265127
title: UFSRATPaperDUDEAnalysis

description: Raw data from running USR, UFSRAT and ECFP4 on the DUD-E dataset