cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.14457/tu.the.2022.201
title: ความสัมพันธ์ระหว่างการบริหารเงินทุนหมุนเวียนและต้นทุนของเงินทุนต่อผลการดำเนินงานของบริษัทที่จดทะเบียนในตลาดหลักทรัพย์แห่งประเทศไทย

description: การค้นคว้าอิสระครั้งนี้มีวัตถุประสงค์เพื่อศึกษาเพื่อศึกษาความสัมพันธ์ระหว่างการบริหารเงินทุนหมุนเวียนและต้นทุนของเงินทุนต่อผลการดำเนินงานของบริษัทที่จดทะเบียนในตลาดหลักทรัพย์แห่งประเทศไทย การศึกษาใช้การวิเคราะห์เส้นทาง (Path Analysis) และวิธีการวิเคราะห์การถดถอย (Regression Analysis) ในการวิเคราะห์ข้อมูลของบริษัทที่จดทะเบียนในตลาดหลักทรัพย์แห่งประเทศไทยซึ่งประกอบไปด้วย 8 กลุ่มอุตสาหกรรมระหว่างปี พ.ศ. 2559 ถึง พ.ศ. 2563 รวมทั้งสิ้น 3,210 ตัวอย่าง ผลการศึกษาพบว่า วงจรเงินสด (CCC) มีความสัมพันธ์เชิงลบอย่างมีนัยสำคัญกับอัตราผลตอบแทนจากสินทรัพย์ (ROA) ทั้งทางตรงและทางอ้อมผ่านต้นทุนของเงินทุนถัวเฉลี่ยถ่วงน้ำหนัก (WACC) ในทุกอุตสาหกรรม ยกเว้น อุตสาหกรรมสินค้าอุปโภคบริโภค อุตสาหกรรมเกษตรและอุตสาหกรรมอาหารที่มีความสัมพันธ์ทางอ้อมแบบไม่มีนัยสำคัญ และอุตสาหกรรมทรัพยากรที่มีความสัมพันธ์ทางอ้อมในทางตรงกันข้าม ในส่วนของอัตราส่วนอัตราสินทรัพย์หมุนเวียนต่อสินทรัพย์รวม (CATA) พบว่ามีความสัมพันธ์เชิงบวกกับอัตราผลตอบแทนจากสินทรัพย์ (ROA) ทั้งทางตรงและทางอ้อมผ่านต้นทุนของเงินทุนถัวเฉลี่ยถ่วงน้ำหนัก (WACC) ในทุกอุตสาหกรรม ยกเว้นอุตสาหกรรมทรัพยากร และอุตสาหกรรมเทคโนโลยีที่มีความสัมพันธ์ทางตรงและทางอ้อมแบบไม่มีนัยสำคัญ และอุตสาหกรรมสินค้าอุปโภคบริโภคที่มีความสัมพันธ์ทางอ้อมแบบไม่มีนัยสำคัญ นอกจากนี้ยังพบว่าอัตราส่วนหนี้สินหมุนเวียนต่อสินทรัพย์รวม (CALA) พบว่ามีความสัมพันธ์เชิงลบอัตราผลตอบแทนจากสินทรัพย์ (ROA) แต่มีความสัมพันธ์ทางอ้อมเชิงบวกผ่านต้นทุนของเงินทุนถัวเฉลี่ยถ่วงน้ำหนัก (WACC) ในทุกอุตสาหกรรม อีกทั้งยังพบว่าต้นทุนของเงินทุนถัวเฉลี่ยถ่วงน้ำหนัก (WACC) มีความสัมพันธ์เชิงลบอย่างมีนัยสำคัญกับอัตราผลตอบแทนจากสินทรัพย์ (ROA) ในทุกอุตสาหกรรม การศึกษานี้เป็นประโยชน์ต่อนักลงทุนที่มีความสนใจในการลงทุนในบริษัทที่จดทะเบียนในตลาดหลักทรัพย์แห่งประเทศไทยในการประเมินธุรกิจผ่านการบริหารเงินทุนหมุนเวียนและต้นทุนของเงินทุนของกิจการการ อีกทั้งเพื่อเป็นประโยชน์ต่อผู้บริหารในการประยุกต์ใช้ข้อมูลในการกำหนดกลยุทธ์ในการบริหารเงินทุนหมุนเวียน และบริหารต้นทุนของเงินทุนเพื่อนำไปสู่การเพิ่มผลดำเนินงานของกิจการ
DOI: 10.14457/tu.the.2022.203
title: การใช้วิธีคิดต้นทุนฐานกิจกรรมของโฮสเทลแห่งหนึ่งในกรุงเทพมหานคร

description: การค้นคว้าอิสระครั้งนี้มีวัตถุประสงค์เพื่อศึกษาระบบบัญชีต้นทุนฐานกิจกรรมของ โฮสเทลแห่งหนึ่งในกรุงเทพมหานคร เพื่อใช้ในการวิเคราะห์ต้นทุน โดยมีวัตถุประสงค์ 3 ประการ คือ เพื่อศึกษาระบบบัญชีต้นทุนฐานกิจกรรมของโฮสเทลแห่งหนึ่งในกรุงเทพมหานคร เพื่อออกแบบระบบบัญชีต้นทุนฐานกิจกรรมของโฮสเทลแห่งหนึ่งในกรุงเทพมหานคร และเพื่อวิเคราะห์ต้นทุนของโฮสเทลแห่งหนึ่งในกรุงเทพมหานครตามระบบบัญชีต้นทุนฐานกิจกรรมผลจากการศึกษาครั้งนี้พบว่าต้นทุนต่อหน่วยรายศูนย์กิจกรรม มีต้นทุนเท่ากับ 262.50 ต่อผู้เข้าพัก ต่อวัน ซึ่งเมื่อเทียบกับราคาห้องพักพบว่าราคาห้องพักทุกประเภทยังสามารถสร้างกำไรสูงกว่าเป้าหมายคือร้อยละ 20 ยกเว้นห้องพักประเภทดอร์มิทอรีที่มีราคาห้องพักต่ำกว่าต้นทุน ผู้ศึกษาจึงแนะนำให้ปรับปรุงราคาห้องพักประเภทดอร์มิทอรีให้สูงขึ้นเพื่อสอดคล้องกับต้นทุนฐานกิจกรรมของโฮสเทล
DOI: 10.14457/tu.the.2022.204
title: Assessing the market potential and entry into Vietnam for dynasty ceramic

description: The independent study is presented to the analysis of the opportunity to expand the international markets, especially in ASEAN countries, for Dynasty Ceramic which is a Thailand’s market leader of ceramic tiles. The purpose of the study is to evaluate the potential opportunities for the best product to the highest value end user in ASEAN, to select the best potential market to enter and to develop an effective market entry strategy for that country. In order for the readers to have a proper background understanding of the subjects being discussed, the study gives the company’s background and review of literatures starting from basic such as what is Dynasty Ceramic, who is their main customers in overseas countries and the demand of ceramic tiles in ASEAN countries. Through the case study involving the CEO’s interview, accessing information in the company’s website and internal reports, the analysis tools to assess which country is the best potential country in ASEAN that the company should enter to expand its market and how to do market entry strategy and provide the recommendations and conclusions which are identified and discussed in more details. The study finds that the potential market will be helpful for the company to increase the opportunity to expand the international markets. According to the findings, the study comes up with recommendations and conclusions for Dynasty Ceramic to increase its sales in overseas countries in ASEAN markets.
DOI: 10.14457/tu.the.2022.206
title: Factors influencing the generation Y consumer’s decision-making along the customer journey of pick up and passenger cars

description: Thailand's growing economy is significantly influenced by the car industry. Currently, there is high competition in the automobile sector, which is supported by strong advertising and marketing activities. The two most popular vehicles are pickup trucks and passenger cars. In order to quickly capture the market and customer need, this research study aims to investigate the factors that influence generation Y's decision to purchase a vehicle along their customer journey. This research uses qualitative research. Data was gathered using an in-depth interview approach with open-ended questions and a semi-structured format to collect data.Generation Y, which represents the potential customers with purchasing power, will be the main focus of this study. The sample group had an average age of between 22 and 41 and had recently bought either pickup trucks or passenger cars. The car must be brand new and cost between 500,000 and 900,000 Thai baht. It is the range of prices that members of Generation Y can afford.Regarding the research finding, we found that their customer journey steps are not linear. Online and offline channels are utilized in their journey. Each stage of the journey has similarities and differences in consumers' behavior. The important factors that influence generation Y consumers' pickup and passenger car purchasing decisions are product, price, and financial aspects, respectively. Vehicle manufacturers and dealers can use the research findings to better understand their customers and plan and optimize their marketing strategies in line with consumer behavior in order to increase competitiveness, expand their customer base, as well as encourage repeat purchases from current customers.
DOI: 10.14457/tu.the.2022.207
title: A turnaround strategy for Haidilao after the pandemic

description: Haidilao is a Chinese Hot pot chain restaurant with branches in many countries worldwide. Haidilao has grown to have more than 1,000 stores in a few years. Its critical success factor is providing service beyond customers' expectations.Although branch expansion continues, the business performance of Haidilao overseas is reversed. The company recognized losses three years in a row from 2019-2021 during the global pandemic. This independent study aims to analyze the causes of the company's losses. Also, provide appropriate recommendations for turning around its business in the overseas market, particularly in Thailand. This research would utilize the company's secondary data from the annual report and the Application Proof of Super Hi International Holding LTD., the overseas business that recently spun off from its mother company. This research can be used by chain restaurants in the food and beverage industry to improve business performance by cutting costs and increasing sales to achieve the company’s expected profits.
DOI: 10.5519/qd.8ckzfro7
title: Query on the Natural History Museum Data Portal (data.nhm.ac.uk) (65 records)
DOI: 10.15151/esrf-es-1093885726
title: Italian CryoEM Bag (ICB)

description: This BAG application builds on the development of single particle cryo-EM in the Italian Structural Biology community, as in Italy there is no top-end instrument available. The groups in this application have acquired know-how in cryo.EM through international collaborations or by acquiring medium-level in-house equipment. Access to the CM01 beamline at the ESRF has been instrumental for the achievement of high-profile scientific results and publications in top journals. Presently three screening microscopes are available in Italy, these instruments will boost sample production and the number of applications to CM01. Given these premises a BAG from Italian institutions could ensure timely data collection, nurturing the expansion of the field in Italy and a high-level scientific production.
DOI: 10.6084/m9.figshare.21161144
title: Mechanistic target of rapamycin (mTOR) regulates self-sustained quiescence, tumor indolence, and late clinical metastasis in a Beclin-1-dependent manner

description: Self-sustained quiescence (SSQ) has been characterized as a stable but reversible non-proliferative cellular state that limits the cloning of cultured cancer cells. By developing refined clonogenic assays, we showed here that cancer cells in SSQ can be selected with anticancer agents and that culture at low cell density induced SSQ in pancreas and prostate adenocarcinoma cells. Pre-culture of cells in 3D or their pretreatment with pharmacological inhibitors of mechanistic target of rapamycin (mTOR) synergize with low cell density for induction of SSQ in a Beclin-1-dependent manner. Dissociated pancreatic adenocarcinoma (PAAD) cells rendered defective for SSQ by down-regulating Beclin-1 expression exhibit higher tumor growth rate when injected subcutaneously into mice. Conversely, dissociated PAAD cells in SSQ promote the formation of small indolent tumors that eventually transitioned to a rapid growth phase. <i>Ex vivo</i> clonogenic assays showed that up to 40% of clonogenic cancer cells enzymatically dissociated from resected fast-growing tumors could enter SSQ, suggesting that SSQ could significantly impact the proliferation of cancer cells that are naturally dispersed from tumors. Remarkably, the kinetics of clinical metastatic recurrence in 124 patients with pancreatic adenocarcinoma included in the TGCA-PAAD project could be predicted from Beclin-1 and Cyclin-A2 mRNA levels in their primary tumor, Cyclin A2 mRNA being a marker of both cell proliferation and mTOR complex 1 activity. Overall, our data show that SSQ is likely to promote the late development of clinical metastases and suggest that identifying new agents targeting cancer cells in SSQ could help improve patient survival.
DOI: 10.6084/m9.figshare.21161144.v2
title: Mechanistic target of rapamycin (mTOR) regulates self-sustained quiescence, tumor indolence, and late clinical metastasis in a Beclin-1-dependent manner

description: Self-sustained quiescence (SSQ) has been characterized as a stable but reversible non-proliferative cellular state that limits the cloning of cultured cancer cells. By developing refined clonogenic assays, we showed here that cancer cells in SSQ can be selected with anticancer agents and that culture at low cell density induced SSQ in pancreas and prostate adenocarcinoma cells. Pre-culture of cells in 3D or their pretreatment with pharmacological inhibitors of mechanistic target of rapamycin (mTOR) synergize with low cell density for induction of SSQ in a Beclin-1-dependent manner. Dissociated pancreatic adenocarcinoma (PAAD) cells rendered defective for SSQ by down-regulating Beclin-1 expression exhibit higher tumor growth rate when injected subcutaneously into mice. Conversely, dissociated PAAD cells in SSQ promote the formation of small indolent tumors that eventually transitioned to a rapid growth phase. <i>Ex vivo</i> clonogenic assays showed that up to 40% of clonogenic cancer cells enzymatically dissociated from resected fast-growing tumors could enter SSQ, suggesting that SSQ could significantly impact the proliferation of cancer cells that are naturally dispersed from tumors. Remarkably, the kinetics of clinical metastatic recurrence in 124 patients with pancreatic adenocarcinoma included in the TGCA-PAAD project could be predicted from Beclin-1 and Cyclin-A2 mRNA levels in their primary tumor, Cyclin A2 mRNA being a marker of both cell proliferation and mTOR complex 1 activity. Overall, our data show that SSQ is likely to promote the late development of clinical metastases and suggest that identifying new agents targeting cancer cells in SSQ could help improve patient survival.
DOI: 10.6084/m9.figshare.21161144.v1
title: Mechanistic target of rapamycin (mTOR) regulates self-sustained quiescence, tumor indolence, and late clinical metastasis in a Beclin-1-dependent manner

description: Self-sustained quiescence (SSQ) has been characterized as a stable but reversible non-proliferative cellular state that limits the cloning of cultured cancer cells. By developing refined clonogenic assays, we showed here that cancer cells in SSQ can be selected with anticancer agents and that culture at low cell density induced SSQ in pancreas and prostate adenocarcinoma cells. Pre-culture of cells in 3D or their pretreatment with pharmacological inhibitors of mechanistic target of rapamycin (mTOR) synergize with low cell density for induction of SSQ in a Beclin-1-dependent manner. Dissociated pancreatic adenocarcinoma (PAAD) cells rendered defective for SSQ by down-regulating Beclin-1 expression exhibit higher tumor growth rate when injected subcutaneously into mice. Conversely, dissociated PAAD cells in SSQ promote the formation of small indolent tumors that eventually transitioned to a rapid growth phase. <i>Ex vivo</i> clonogenic assays showed that up to 40% of clonogenic cancer cells enzymatically dissociated from resected fast-growing tumors could enter SSQ, suggesting that SSQ could significantly impact the proliferation of cancer cells that are naturally dispersed from tumors. Remarkably, the kinetics of clinical metastatic recurrence in 124 patients with pancreatic adenocarcinoma included in the TGCA-PAAD project could be predicted from Beclin-1 and Cyclin-A2 mRNA levels in their primary tumor, Cyclin A2 mRNA being a marker of both cell proliferation and mTOR complex 1 activity. Overall, our data show that SSQ is likely to promote the late development of clinical metastases and suggest that identifying new agents targeting cancer cells in SSQ could help improve patient survival.
DOI: 10.6084/m9.figshare.22274767
title: A large-scale CHP system

description: A large-scale CHP system with a 69 node heat network and IEEE 118 bus power network.
DOI: 10.17632/jhrcyh94wd.1
title: Floreste et al. (2022) - Liver vs. spleen - raw data table

description: This is the raw data set used in the analysis from the manuscript "Liver vs. spleen: time course of organ-dependent immune gene expression in LPS-stimulated toads" by Felipe Floreste et al., published through DOI:
This table contains values of immune proteins mRNA levels of Rhinella diptycha toads injected with LPS or saline and individually sampled 1h, 3h, 6h and 18h post-injection. Values are expressed as fold-change (FC) relative to the gene expression of housekeeping gene β-actin.
DOI: 10.17632/r9dw8htvt2.1
title: Presence of polyketide synthase (PKS) gene and counterpart virulence determinants in Klebsiella pneumoniae strains enhances colorectal cancer progression in-vitro.

description: This study aims to investigate the effect of colibactin producing Klebsiella pneumoniae (PKS-positive K. pneumoniae) in enhancing colorectal cancer (CRC) cell proliferation in-vitro. The findings in this study revealed a greater enhancement of cell proliferation among CRC cell lines that are exposed to PKS-positive K. pneumoniae antigens compared to PKS-negative K. pneumoniae. In addition, certain virulence factors such as presence of genes confering siderophore production had a synergistic effect in enhancing CRC cell line proliferation. To further validate the findings, ECIS assay was performed to show that the greater enhancement of cell proliferation observed among CRC cell lines were consistent with the presence of PKS-positive K. pneumoniae exposure.
DOI: 10.5517/ccdc.csd.cc28qkvf
title: CCDC 2107065: Experimental Crystal Structure Determination

description: Related Article: Yinjun Wang, Hao Jiang, Huifei Wang, Zehuai Mou|2022|J.Rare Earths|41|381|doi:10.1016/j.jre.2022.02.018
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.6084/m9.figshare.22274866
title: Global plant-beneficial bacteria

description: This study investigates the biogeography and diversity of plant-beneficial bacteria in global soils
DOI: 10.18419/darus-3179
title: Molecular simulation scripts for bulk solutions

description: GROMACS molecular simulation input files for bulk solutions of NaCl and Na2SO4. Initial configuration with different salt concentration can be generated using the Python script ConfigurationGenerator.py, and successive GROMACS runs can be performed by running the runall.sh Bash script.
DOI: 10.18419/darus-3179/1
title: tip4peps.itp

description: GROMACS ff file
DOI: 10.18419/darus-3179/2
title: ffbonded.itp

description: GROMACS ff file
DOI: 10.18419/darus-3179/3
title: molecules.rtp

description: GROMACS ff file
DOI: 10.18419/darus-3179/4
title: conf.gro

description: GROMACS configuration file
DOI: 10.18419/darus-3179/5
title: nvt.mdp

description: GROMACS input file
DOI: 10.18419/darus-3179/6
title: ffnonbonded.itp

description: GROMACS ff file
DOI: 10.18419/darus-3179/7
title: npt.mdp

description: GROMACS input file
DOI: 10.18419/darus-3179/8
title: topol.top

description: GROMACS topology file
DOI: 10.18419/darus-3179/9
title: atomtypes.atp

description: GROMACS ff file
DOI: 10.18419/darus-3179/10
title: topol.top

description: GROMACS topology file
DOI: 10.18419/darus-3179/11
title: forcefield.itp

description: GROMACS ff file
DOI: 10.18419/darus-3179/12
title: conf.gro

description: GROMACS configuration file
DOI: 10.18419/darus-3179/13
title: ions.itp

description: GROMACS ff file
DOI: 10.18419/darus-3179/14
title: ConfigurationGenerator.py

description: Python script
DOI: 10.18419/darus-3179/15
title: prod.mdp

description: GROMACS input file
DOI: 10.18419/darus-3179/16
title: ConfigurationGenerator.py

description: Python script
DOI: 10.18419/darus-3179/17
title: runall.sh

description: Bash script
DOI: 10.18419/darus-3179/18
title: runall.sh

description: Bash script
DOI: 10.18419/darus-3179/19
title: README.md

description: README file explaining the content of the dataset
DOI: 10.17909/4mwv-wv48
title: EGS-ULIRGs paper data

description: EGS-ULIRGs paper data for target EGS 22.
DOI: 10.6084/m9.figshare.22133624
title: DIF MASC-FEM.csv

description: Data from: FWC, FWWC, UEC, UWC, UCL, UWCL
DOI: 10.6084/m9.figshare.22133624.v1
title: DIF MASC-FEM.csv

description: Data from: FWC, FWWC, UEC, UWC, UCL, UWCL
DOI: 10.5281/zenodo.7716990
title: Azimuthal C/O Variations in a Planet-Forming Disk

description: <strong>DALI physical-chemical disk models presented in 'Azimuthal C/O Variations in a Planet-Forming Disk' (Keyte et al. 2023).</strong> There are two individual models included here. The 'baseline' model is used to produce outputs for the region of the disk where C/O=0.5. The 'elevated' model is used to produce outputs for the regions of the disk where C/O=1.5. The baseline model can be run in the normal way, but the outputs themselves are already included in the folder. The 'elevated' model will not run in the regular way. The source code has been edited so that it can take in the abundances from a previous run as the starting point for the chemistry (in the form of an <em>out.dat</em> style table). The outputs are already included, but should you want to rerun the model yourself, follow the steps in the readme file within the folder. The final 'composite' model presented in the paper is created by splicing together the outputs (as described in Keyte et al. 2023). This is achieved using a custom Python script, please contact me if you would like to use this.
DOI: 10.5281/zenodo.7716991
title: Azimuthal C/O Variations in a Planet-Forming Disk

description: <strong>DALI physical-chemical disk models presented in 'Azimuthal C/O Variations in a Planet-Forming Disk' (Keyte et al. 2023).</strong> There are two individual models included here. The 'baseline' model is used to produce outputs for the region of the disk where C/O=0.5. The 'elevated' model is used to produce outputs for the regions of the disk where C/O=1.5. The baseline model can be run in the normal way, but the outputs themselves are already included in the folder. The 'elevated' model will not run in the regular way. The source code has been edited so that it can take in the abundances from a previous run as the starting point for the chemistry (in the form of an <em>out.dat</em> style table). The outputs are already included, but should you want to rerun the model yourself, follow the steps in the readme file within the folder. The final 'composite' model presented in the paper is created by splicing together the outputs (as described in Keyte et al. 2023). This is achieved using a custom Python script, please contact me if you would like to use this.
DOI: 10.6084/m9.figshare.20410685
title: Safety and tolerability of spesolimab in patients with ulcerative colitis

description: Interleukin (IL)-36 signaling has been shown to be increased in ulcerative colitis (UC). Spesolimab, a novel humanized monoclonal antibody, targets the IL-36 pathway. We report safety, immunogenicity, and efficacy data of intravenous (IV) spesolimab in UC. Study 1: phase II, randomized, placebo-controlled trial (300 mg single dose; 450 mg every 4 weeks [q4w]; or 1,200 mg q4w, three doses). Study 2: phase IIa, randomized, placebo-controlled trial (1,200 mg q4w). Study 3: phase IIa, open-label, single-arm trial (1,200 mg q4w). Studies lasted 12 weeks, with a 12-, 24-, and 16-week safety follow-up, respectively. Adver+se event (AE) rates were similar for spesolimab and placebo in Studies 1 (N = 98; 64.9%; 65.2%) and 2 (N = 22; 86.7%; 71.4%); all patients in Study 3 (N = 8) experienced AEs. The most frequent investigator-assessed drug-related (spesolimab; placebo) AEs were skin rash (5.4%; 0%) and nasopharyngitis (4.1%; 0%) in Study 1; acne (13.3%; 0%) in Study 2; one patient reported skin rash, nasopharyngitis, headache, and acne in Study 3. Efficacy endpoints were not met. Spesolimab was generally well tolerated, with no unexpected safety concerns. The safety data are consistent with studies in other inflammatory diseases.
DOI: 10.6084/m9.figshare.20410685.v2
title: Safety and tolerability of spesolimab in patients with ulcerative colitis

description: Interleukin (IL)-36 signaling has been shown to be increased in ulcerative colitis (UC). Spesolimab, a novel humanized monoclonal antibody, targets the IL-36 pathway. We report safety, immunogenicity, and efficacy data of intravenous (IV) spesolimab in UC. Study 1: phase II, randomized, placebo-controlled trial (300 mg single dose; 450 mg every 4 weeks [q4w]; or 1,200 mg q4w, three doses). Study 2: phase IIa, randomized, placebo-controlled trial (1,200 mg q4w). Study 3: phase IIa, open-label, single-arm trial (1,200 mg q4w). Studies lasted 12 weeks, with a 12-, 24-, and 16-week safety follow-up, respectively. Adver+se event (AE) rates were similar for spesolimab and placebo in Studies 1 (N = 98; 64.9%; 65.2%) and 2 (N = 22; 86.7%; 71.4%); all patients in Study 3 (N = 8) experienced AEs. The most frequent investigator-assessed drug-related (spesolimab; placebo) AEs were skin rash (5.4%; 0%) and nasopharyngitis (4.1%; 0%) in Study 1; acne (13.3%; 0%) in Study 2; one patient reported skin rash, nasopharyngitis, headache, and acne in Study 3. Efficacy endpoints were not met. Spesolimab was generally well tolerated, with no unexpected safety concerns. The safety data are consistent with studies in other inflammatory diseases.