cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.17632/jb67p4cr4c.1
title: data

description: Aims: Emodin, a natural anthraquinone, exerts antitumor effects by increasing reactive oxygen species (ROS) and inducing apoptosis, autophagy, and cell-cycle arrest. However, its potential to induce ferroptosis, a distinct iron-dependent cell death, in hepatocellular carcinoma (HCC) remains unexplored.
Materials and methods: The anti-proliferative effect of Emodin was assessed in human HCC cell lines HepG2 and MHCC97H. Ferroptosis was evaluated following treatment with 40 μM Emodin for 24 h, measuring ROS, lipid peroxidation, glutathione levels, and mitochondrial morphology. Molecular mechanisms were investigated via reverse transcription polymerase chain reaction (RT-qPCR), western blot, and functional rescue experiments. A HepG2 xenograft model (25 and 50 mg/kg Emodin, intraperitoneal.) and immunohistochemistry were used to confirm the findings in vivo.
Key findings: Emodin inhibited HCC cell proliferation and induced ferroptosis, characterized by ROS accumulation, lipid peroxidation, and reduced glutathione levels, mitochondrial membrane potential, and glutathione peroxidase 4 (GPX4) expression. Mechanistically, Emodin upregulated microRNA-4465 (miR-4465), which directly targeted and suppressed the NFE2 like bZIP transcription factor 3 (NFE2L3). This led to inhibition of the NFE2L3/3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR)/GPX4 signaling axis. Overexpression of NFE2L3 rescued cells from Emodin-induced ferroptosis. In the xenograft model, Emodin significantly suppressed tumor growth and downregulated the NFE2L3/HMGCR/GPX4 pathway in tumor tissues.
Significance: Our study demonstrates that Emodin induces ferroptosis through the miR-4465/NFE2L3/HMGCR/GPX4 axis in HCC, revealing NFE2L3's role in ferroptosis and suggesting Emodin as a promising therapeutic candidate.
DOI: 10.17632/xzytzc483n
title: Research database "Automatic Discontinuation of Mechanical Ventilation in Obese Patients After Cardiac Surgery: A Retrospective Analysis."

description: Introduction: There is a big progress in providing respiratory support in recent years with increasing safety and decreasing duration. However, there are still many unanswered questions, particularly about successful weaning from invasive ventilation. We consider to use an intellectual ventilation mode to optimize weaning from invasive ventilation.
Objectives: The main goal of this retrospective analysis was to assess the possibility of based on Adaptive Support Ventilation mode to select appropriate ventilatory parameters for effectively discontinuing ventilatory parameters in patients with obesity after cardiac surgery. Additionally, we hypothesize that this approach can optimize diaphragmatic function in early restoration of diaphragmatic activity and decreasing the workload.
Material and Methods: We compare the discontinuation processes in our previous trials. It was two trials about using INTELLiVENT – ASV® mode and conventional ventilation modes (SIMV – switching to PSV after restoration of own respiratory activity). In the first part we assess 80 patients with BMI &gt; 30 kg/m2, 40 of them were ventilated in INTELLiVENT – ASV®, and 40 in SIMV – PSV modes. In the second part we considered 32 patients with BMI &gt; 35 kg/m2; 16 of them were ventilated in INTELLiVENT – ASV®, and 16 in SIMV – PSV modes.
Results: The duration of spontaneous ventilation (without any mandatory breaths) was longer in the groups that used the automatic INTELLiVENT – ASV® mode. The pressure support (PS) and P0.1 level was lower in these groups. The tidal volume and PEEP levels were higher in the groups using conventional modes. Also, in the INTELLiVENT-ASV groups, the number of manual ventilator settings and the time physicians spent near the ventilator before tracheal extubation were significantly lower.
Conclusion: The using of intellectual modes in weaning of respiratory support process safe for cardiac surgery patients with obesity (including in patients with BMI &gt; 35kg/m2). This reduces the duration of mandatory breathing periods, decreases tidal volume, pressure support, and PEEP levels, without compromising arterial oxygenation. Moreover, it helps to reduce the time that physicians spend near the respirator.
DOI: 10.17632/xzytzc483n.1
title: Research database "Automatic Discontinuation of Mechanical Ventilation in Obese Patients After Cardiac Surgery: A Retrospective Analysis."

description: Introduction: There is a big progress in providing respiratory support in recent years with increasing safety and decreasing duration. However, there are still many unanswered questions, particularly about successful weaning from invasive ventilation. We consider to use an intellectual ventilation mode to optimize weaning from invasive ventilation.
Objectives: The main goal of this retrospective analysis was to assess the possibility of based on Adaptive Support Ventilation mode to select appropriate ventilatory parameters for effectively discontinuing ventilatory parameters in patients with obesity after cardiac surgery. Additionally, we hypothesize that this approach can optimize diaphragmatic function in early restoration of diaphragmatic activity and decreasing the workload.
Material and Methods: We compare the discontinuation processes in our previous trials. It was two trials about using INTELLiVENT – ASV® mode and conventional ventilation modes (SIMV – switching to PSV after restoration of own respiratory activity). In the first part we assess 80 patients with BMI &gt; 30 kg/m2, 40 of them were ventilated in INTELLiVENT – ASV®, and 40 in SIMV – PSV modes. In the second part we considered 32 patients with BMI &gt; 35 kg/m2; 16 of them were ventilated in INTELLiVENT – ASV®, and 16 in SIMV – PSV modes.
Results: The duration of spontaneous ventilation (without any mandatory breaths) was longer in the groups that used the automatic INTELLiVENT – ASV® mode. The pressure support (PS) and P0.1 level was lower in these groups. The tidal volume and PEEP levels were higher in the groups using conventional modes. Also, in the INTELLiVENT-ASV groups, the number of manual ventilator settings and the time physicians spent near the ventilator before tracheal extubation were significantly lower.
Conclusion: The using of intellectual modes in weaning of respiratory support process safe for cardiac surgery patients with obesity (including in patients with BMI &gt; 35kg/m2). This reduces the duration of mandatory breathing periods, decreases tidal volume, pressure support, and PEEP levels, without compromising arterial oxygenation. Moreover, it helps to reduce the time that physicians spend near the respirator.
DOI: 10.17632/x5c38ztg9m
title: Organization of Grooming in Domestic Cats 2025

description: Protocol of 40 grooming bouts from 8 different cats. Data in support of the submitted publication "Decoding Diversity: Are there Patterns in the Organization of Grooming Movements in Domestic Cats"
DOI: 10.17632/x5c38ztg9m.1
title: Organization of Grooming in Domestic Cats 2025

description: Protocol of 40 grooming bouts from 8 different cats. Data in support of the submitted publication "Decoding Diversity: Are there Patterns in the Organization of Grooming Movements in Domestic Cats"
DOI: 10.15468/dl.ah5rjn
title: Occurrence Download

description: A dataset containing 67789 species occurrences available in GBIF matching the query:
{
 "and" : [
 "BasisOfRecord is Human Observation",
 "Country is United Kingdom of Great Britain and Northern Ireland",
 "TaxonKey is Vanessa atalanta",
 "Year 2014-2014"
 ]
}

 The dataset includes 67789 records from 51 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0058825-251120083545085/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.17632/kwhyp8b2tm
title: Dataset for Manuscript: Relating sensor-based insect counts to pest and natural enemy populations in the field - potential proxy for quantifying biological control

description: Data from sensor measurements and corresponding validation sampling. 
aphid_data_repository contains sensor-based aphid counts and field-sampled aphid densities and colonization 
biodiversity_data_repository contains sensor based biodiversity and biomass proxies and field-sampled natural enemy abundance and diversity
DOI: 10.15468/dl.kgtk6u
title: Occurrence Download

description: A dataset containing 3 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Azorinus abbreviatus, Azor solidus, Azorinus coarctatus, Novaculina andamanensis, Solecurtus abbreviatus, Solecurtus coarctatus, Solecurtus solidus, Solen coarctatus, Zozia coarctatus)",
 "HasCoordinate is true",
 "BasisOfRecord is one of (Observation, Machine Observation, Human Observation, Occurrence evidence)",
 "OccurrenceStatus is Present",
 "Year is greater than or equal to 1950"
 ]
}

 The dataset includes 3 records from 2 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0058883-251120083545085/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.17632/kwhyp8b2tm.1
title: Dataset for Manuscript: Relating sensor-based insect counts to pest and natural enemy populations in the field - potential proxy for quantifying biological control

description: Data from sensor measurements and corresponding validation sampling. 
aphid_data_repository contains sensor-based aphid counts and field-sampled aphid densities and colonization 
biodiversity_data_repository contains sensor based biodiversity and biomass proxies and field-sampled natural enemy abundance and diversity
DOI: 10.15468/dl.f2bj2b
title: Occurrence Download

description: A dataset containing 10 species occurrences available in GBIF matching the query:
{"type":"and","predicates":[{"type":"equals","key":"GADM_LEVEL_0_GID","value":"ARG","matchCase":false},{"type":"equals","key":"GADM_LEVEL_1_GID","value":"ARG.22_1","matchCase":false},{"type":"equals","key":"GADM_LEVEL_2_GID","value":"ARG.22.3_1","matchCase":false},{"type":"equals","key":"CLASS_KEY","value":"212","matchCase":false},{"type":"greaterThanOrEquals","key":"YEAR","value":"2015","matchCase":false},{"type":"not","predicate":{"type":"in","key":"BASIS_OF_RECORD","values":["MATERIAL_CITATION","MATERIAL_SAMPLE","PRESERVED_SPECIMEN"],"matchCase":false}},{"type":"lessThanOrEquals","key":"COORDINATE_UNCERTAINTY_IN_METERS","value":"10000","matchCase":false},{"type":"equals","key":"LICENSE","value":"CC BY 4.0","matchCase":false}]}

 The dataset includes 10 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0058881-251120083545085/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.5281/zenodo.17970136
title: Energy System and Emissions Impacts of an 8-Fold Increase in Liquid Fuels Combustion Efficiency

description: Motivated by an ancient account of dramatic gains in liquid fuel efficiency, this study uses the Global Change Analysis Model (GCAM) to examine the system-wide effects of an 8-fold increase in refined liquids end-use efficiency by 2050. Absent explicit climate policy, these efficiency improvements sharply reduce liquid fuel use and place global CO₂ emissions on a pathway consistent with limiting warming to below 1.5 °C, despite significant rebound effects that increase demand for energy services, particularly in transportation. We find that under such improvements CO2 emissions could decline by roughly 25 percent by 2030 and nearly 50 percent by mid-century. The resulting contraction in liquid fuel demand propagates to other sectors via price signals, reducing consumption of other fossil fuels and lowering system-wide energy costs, with attendant potential to alleviate recent inflationary pressure. The results provide further support for the central role of end-use efficiency in deep decarbonization strategies and its ability to amplify complementary fuel policies.
DOI: 10.17632/m7t28g44tz
title: Dataset for Spatial and Interpretive Mapping of the Sahel Transnational Conflict Economies

description: The central hypothesis of this study is that the Sahel conflict, spanning over a decade, is sustained by transnational conflict economies whose spatial dynamics remain unmapped and unclearly interpreted, hindering precise interventions. We argue that mapping conflict economies using an integrated Actor–Sector–Activity–Event (ASAE) lens can illuminate actionable intervention points that conventional, broad-based conflict avoidance strategies often overlook. 

We gathered data using document reviews, expert interviews and specialised databases (e.g., Illicit Arms Flow Database, Armed Conflict and Event Database). Data cover actors in cross-border crimes and conflicts, sectors (financial, agricultural, humanitarian, political governance), activities (resource exploitation, mercenary movements, drug–arms–human trafficking) and conflict events (battles, riots, protests). We cover five key Sahelian countries - Nigeria, Burkina Faso, Mali, Chad and Sudan - each serving as a pivotal node in the region's transnational conflict economies. 

Data integration via geospatial and network analyses reveals three distinct conflict economy blocks where violence concentrates, based on the clustering and interaction of conflict events, illicit activities, and key actors and sectors that serve as points of infiltration. 

Block 1: Liptako-Gourma, dominated by gold smuggling, livestock rustling and JNIM influence. 

Block 2: Lake Chad borderlands, with aid diversion, kidnapping, illegal taxation by ISWAP and Boko Haram. 

Block 3: Darfur–Kordofan–Nile Valley, shaped by mineral and arms flows under Rapid Support Forces’ control.

Together, these blocks account for most conflict hotspots since 2023 and are linked by cross-border trafficking routes, shifting actor alliances and spillover displacement crises, forming a structural backbone of the Sahel conflict economies where violence, governance voids and economic control reinforce regional instability.

This study – the first to adopt an ASAE-informed mapping - reveals a path to targeted, block-specific interventions, including halting specific illicit commodity flows (e.g., gold in Liptako-Gourma, minerals in Darfur corridor, aid diversion channels in Lake Chad), blocking funding and tax extraction networks, and closing cross-border smuggling routes through joint border patrols, forensic finance tracing, and coordinated sanctions on key actors. 

Our data should be interpreted as an ASAE-structured snapshot of transnational conflict economies in the Sahel for 2023–2025, best used to identify and compare actors, sectors, activities, and events within and across the three blocks rather than to make fine-grained temporal claims. Users are encouraged to employ our data for spatial, network and risk mapping, ideally alongside complementary qualitative or longitudinal sources to track how conflict economies evolve over time.
DOI: 10.5281/zenodo.17970135
title: Energy System and Emissions Impacts of an 8-Fold Increase in Liquid Fuels Combustion Efficiency

description: Motivated by an ancient account of dramatic gains in liquid fuel efficiency, this study uses the Global Change Analysis Model (GCAM) to examine the system-wide effects of an 8-fold increase in refined liquids end-use efficiency by 2050. Absent explicit climate policy, these efficiency improvements sharply reduce liquid fuel use and place global CO₂ emissions on a pathway consistent with limiting warming to below 1.5 °C, despite significant rebound effects that increase demand for energy services, particularly in transportation. We find that under such improvements CO2 emissions could decline by roughly 25 percent by 2030 and nearly 50 percent by mid-century. The resulting contraction in liquid fuel demand propagates to other sectors via price signals, reducing consumption of other fossil fuels and lowering system-wide energy costs, with attendant potential to alleviate recent inflationary pressure. The results provide further support for the central role of end-use efficiency in deep decarbonization strategies and its ability to amplify complementary fuel policies.
DOI: 10.17632/m7t28g44tz.1
title: Dataset for Spatial and Interpretive Mapping of the Sahel Transnational Conflict Economies

description: The central hypothesis of this study is that the Sahel conflict, spanning over a decade, is sustained by transnational conflict economies whose spatial dynamics remain unmapped and unclearly interpreted, hindering precise interventions. We argue that mapping conflict economies using an integrated Actor–Sector–Activity–Event (ASAE) lens can illuminate actionable intervention points that conventional, broad-based conflict avoidance strategies often overlook. 

We gathered data using document reviews, expert interviews and specialised databases (e.g., Illicit Arms Flow Database, Armed Conflict and Event Database). Data cover actors in cross-border crimes and conflicts, sectors (financial, agricultural, humanitarian, political governance), activities (resource exploitation, mercenary movements, drug–arms–human trafficking) and conflict events (battles, riots, protests). We cover five key Sahelian countries - Nigeria, Burkina Faso, Mali, Chad and Sudan - each serving as a pivotal node in the region's transnational conflict economies. 

Data integration via geospatial and network analyses reveals three distinct conflict economy blocks where violence concentrates, based on the clustering and interaction of conflict events, illicit activities, and key actors and sectors that serve as points of infiltration. 

Block 1: Liptako-Gourma, dominated by gold smuggling, livestock rustling and JNIM influence. 

Block 2: Lake Chad borderlands, with aid diversion, kidnapping, illegal taxation by ISWAP and Boko Haram. 

Block 3: Darfur–Kordofan–Nile Valley, shaped by mineral and arms flows under Rapid Support Forces’ control.

Together, these blocks account for most conflict hotspots since 2023 and are linked by cross-border trafficking routes, shifting actor alliances and spillover displacement crises, forming a structural backbone of the Sahel conflict economies where violence, governance voids and economic control reinforce regional instability.

This study – the first to adopt an ASAE-informed mapping - reveals a path to targeted, block-specific interventions, including halting specific illicit commodity flows (e.g., gold in Liptako-Gourma, minerals in Darfur corridor, aid diversion channels in Lake Chad), blocking funding and tax extraction networks, and closing cross-border smuggling routes through joint border patrols, forensic finance tracing, and coordinated sanctions on key actors. 

Our data should be interpreted as an ASAE-structured snapshot of transnational conflict economies in the Sahel for 2023–2025, best used to identify and compare actors, sectors, activities, and events within and across the three blocks rather than to make fine-grained temporal claims. Users are encouraged to employ our data for spatial, network and risk mapping, ideally alongside complementary qualitative or longitudinal sources to track how conflict economies evolve over time.
DOI: 10.17632/t6378v3pjd
title: Data on Impact of Rural Road Infrastructure on Women Nutrition, Empowerment Outcomes

description: The study measured the impact of rural road infrastructure improvement on women’s empowerment and household nutrition. The study employed the Abbreviated Women Empowerment in Agriculture Index (AWEAI), Household dietary diversity Score (HDDS), Minimum Dietary Diversity Score for Women (MDDW), Difference-in-Difference (DiD) and propensity score matching (PSM) models to analyse a secondary dataset of 1,294 respondents obtained from the Value Chain Development Programme (VCDP) in Nigeria between 2019 and 2022.The study found that between 2019 and 2022, the proportion of disempowered women reduced more for VCDP beneficiaries with lesser disempowerment gap compared to the non-beneficiaries. Dietary diversity for most households, particularly female-headed beneficiary households, was also higher relative to their non-beneficiary counterparts. Rural road infrastructure improvement had a positive impact on household dietary diversity, women’s dietary diversity, and women’s empowerment. Therefore, the study recommends that government in conjunction with the private sector and supporting international agencies/organizations should consider the incorporation of road infrastructure provision to communities as part of its nutrition, and empowerment, policy.
DOI: 10.17632/t6378v3pjd.1
title: Data on Impact of Rural Road Infrastructure on Women Nutrition, Empowerment Outcomes

description: The study measured the impact of rural road infrastructure improvement on women’s empowerment and household nutrition. The study employed the Abbreviated Women Empowerment in Agriculture Index (AWEAI), Household dietary diversity Score (HDDS), Minimum Dietary Diversity Score for Women (MDDW), Difference-in-Difference (DiD) and propensity score matching (PSM) models to analyse a secondary dataset of 1,294 respondents obtained from the Value Chain Development Programme (VCDP) in Nigeria between 2019 and 2022.The study found that between 2019 and 2022, the proportion of disempowered women reduced more for VCDP beneficiaries with lesser disempowerment gap compared to the non-beneficiaries. Dietary diversity for most households, particularly female-headed beneficiary households, was also higher relative to their non-beneficiary counterparts. Rural road infrastructure improvement had a positive impact on household dietary diversity, women’s dietary diversity, and women’s empowerment. Therefore, the study recommends that government in conjunction with the private sector and supporting international agencies/organizations should consider the incorporation of road infrastructure provision to communities as part of its nutrition, and empowerment, policy.
DOI: 10.17632/7tr83632xd
title: Supplementary data for "Global K cycle revisited: The role of arc hydrothermal systems".

description: S1-Major element concentrations and K isotope compositions of altered cores sample from the Brothers Volcano. S2-Major element concentration of unaltered rocks from the Brothers Volcano.
DOI: 10.17632/7tr83632xd.1
title: Supplementary data for "Global K cycle revisited: The role of arc hydrothermal systems".

description: S1-Major element concentrations and K isotope compositions of altered cores sample from the Brothers Volcano. S2-Major element concentration of unaltered rocks from the Brothers Volcano.
DOI: 10.17632/tk3cn3rhb8.1
title: Raw western blot data-Loss of p53 exacerbates autoimmunity by reprogramming propionyl-CoA metabolism and epigenetics in Treg cells

description: Metabolic regulation is central to the tumor suppressor function of p53. Here we report that propionyl-CoA metabolic remodeling and epigenetic changes underpin p53-mediated restraint of autoimmunity through regulatory T (Treg) cells. By analyzing the human patients with autoimmune diseases, we found p53 expression was significantly reduced in Treg cells negatively correlating with abnormally elevated BCL-6 levels. p53 loss causes dysregulated immune homeostasis and dampens Tregs function in vitro and in vivo. Mechanistically, p53 transcriptionally activates ALDH6A1 expression and propionyl-CoA anabolism to upregulate functional Treg gene expression via histone propionylation. Treg-specific knockout of ALDH6A1 phenocopies the autoimmune responses of p53 deficiency, and propionyl-CoA restoration largely recovers Treg cell function in mice lacking p53 or ALDH6A1. Clinically, impaired p53-ALDH6A1-histone propionylation signaling is observed in AS and SLE patients and correlates with poor efficacy of first-line therapies in autoimmune patients. Together, these findings reveal a directly connection between propionyl-CoA metabolism and epigenetic changes, which is governed by p53 and is crucial for Treg cell function and immune tolerance suppression.