cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.7898852.v1
title: Human dental pulp stem cells transplantation combined with treadmill training in rats after traumatic spinal cord injury

description: Spinal cord injury (SCI) is a disabling condition resulting in deficits of sensory and motor functions, and has no effective treatment. Considering that protocols with stem cell transplantation and treadmill training have shown promising results, the present study evaluated the effectiveness of stem cells from human exfoliated deciduous teeth (SHEDs) transplantation combined with treadmill training in rats with experimental spinal cord injury. Fifty-four Wistar rats were spinalized using NYU impactor. The rats were randomly distributed into 5 groups: Sham (laminectomy with no SCI, n=10); SCI (laminectomy followed by SCI, n=12); SHEDs (SCI treated with SHEDs, n=11); TT (SCI treated with treadmill training, n=11); SHEDs+TT (SCI treated with SHEDs and treadmill training; n=10). Treatment with SHEDs alone or in combination with treadmill training promoted functional recovery, reaching scores of 15 and 14, respectively, in the BBB scale, being different from the SCI group, which reached 11. SHEDs treatment was able to reduce the cystic cavity area and glial scar, increase neurofilament. Treadmill training alone had no functional effectiveness or tissue effects. In a second experiment, the SHEDs transplantation reduced the TNF-α levels in the cord tissue measured 6 h after the injury. Contrary to our hypothesis, treadmill training either alone or in combination, caused no functional improvement. However, SHEDs showed to be neuroprotective, by the reduction of TNF-α levels, the cystic cavity and the glial scar associated with the improvement of motor function after SCI. These results provide evidence that grafted SHEDs might be an effective therapy to spinal cord lesions, with possible anti-inflammatory action.
DOI: 10.6084/m9.figshare.7898837
title: Relationship between ventilation heterogeneity and exercise intolerance in adults with sickle cell anemia

description: Sickle cell anemia (SCA) causes dysfunction of multiple organs, with pulmonary involvement as a major cause of mortality. Recently, there has been growing interest in the nitrogen single-breath washout (N2SBW) test, which is able to detect ventilation heterogeneity and small airway disease when the results of other pulmonary function tests (PFTs) are still normal. Thus, the objectives of the present study were to assess the heterogeneity in the ventilation distribution in adults with SCA and to determine the association between the ventilation distribution and the clinical, cardiovascular, and radiological findings. This cross-sectional study included 38 adults with SCA who underwent PFTs, echocardiography, computed tomography (CT), and 6-min walk test. To evaluate the ventilation heterogeneity, the patients were categorized according to the phase III slope of the N2SBW (SIIIN2). Compared with adults with lower SIIIN2 values, adults with higher SIIIN2 values showed lower hemoglobin levels (P=0.048), a history of acute chest syndrome (P=0.001), an elevated tricuspid regurgitation velocity (P=0.039), predominance of a reticular pattern in the CT (P=0.002), a shorter 6-min walking distance (6MWD) (P=0.002), and lower peripheral oxygen saturation (SpO2) after exercise (P=0.03). SIIIN2 values correlated significantly with hemoglobin (rs=-0.344; P=0.034), forced vital capacity (rs=-0.671; P&lt;0.0001), diffusing capacity for carbon monoxide (rs=-0.376; P=0.019), 6MWD (rs=-0.554; P=0.0003), and SpO2 after exercise (P=0.040). Heterogeneity in the ventilation distribution is one of the most common pulmonary dysfunctions in adults with SCA. Moreover, relationships exist between ventilation heterogeneity, worsening of pulmonary structural damage, and reduced tolerance for exercise.
DOI: 10.6084/m9.figshare.7898843
title: Postoperative Atrial Fibrillation: Evaluation of its Economic Impact on the Costs of Cardiac Surgery

description: Abstract Objective: The objective of this study was to calculate the direct costs of postoperative atrial fibrillation (POAF) in a high-complexity cardiovascular hospital. Methods: We performed a cost analysis with a pairwise-matched design. Twenty-two patients with POAF and 22 patients without this complication were included. Pair-matching was performed (1:1) based on the following criteria: identical type of surgery, similar EuroSCORE II values, and absence of any other postoperative complication. Results: The total hospital cost was significantly higher in the POAF group than in the non-POAF group (US$ 10,880 [± 2,688] vs. US$ 8,856 [± 1,782], respectively, for each patient; P=0.005). This difference was attributable to postoperative costs (US$ 3,103 [± 1,552] vs. US$ 1,238 [± 429]; P=0.0001) for patients with or without POAF, respectively. The median postoperative lengths of stay were 9 (range 5-17) and 5 (3-9) days for patients with and without POAF (P=0.032), respectively. Preoperatively, no differences were found in the EuroSCORE II values (median 1.7 vs. 1.6, respectively; P=0.91) or direct costs (US$ 1,127 vs. US$ 1,063, respectively; P=0.56) between POAF and non-POAF groups. Conclusion: POAF generates a high economic burden in the overall costs of cardiac surgery, and our results reveal the differential contribution of each of the evaluated factors. This information, which was previously unavailable in this setting, is essential for the development of more effective prevention strategies.
DOI: 10.6084/m9.figshare.7898846.v1
title: Rosmarinus officinalis L. increases Caenorhabditis elegans stress resistance and longevity in a DAF-16, HSF-1 and SKN-1-dependent manner

description: Improving overall health and quality of life, preventing diseases and increasing life expectancy are key concerns in the field of public health. The search for antioxidants that can inhibit oxidative damage in cells has received a lot of attention. Rosmarinus officinalis L. represents an exceptionally rich source of bioactive compounds with pharmacological properties. In the present study, we explored the effects of the ethanolic extract of R. officinalis (eeRo) on stress resistance and longevity using the non-parasitic nematode Caenorhabditis elegans as a model. We report for the first time that eeRo increased resistance against oxidative and thermal stress and extended C. elegans longevity in an insulin/IGF signaling pathway-dependent manner. These data emphasize the eeRo beneficial effects on C. elegans under stress.
DOI: 10.6084/m9.figshare.7898828
title: Systemic resistance induction in ‘Ortanique’ tangor

description: Abstract This study aimed to evaluate the quality of ‘Ortanique’ tangor, in the post-harvest and refrigerated storage after application of pre-harvest resistance inducers, in the 2015 and 2016 crops. The experimental design in the field was in completely randomized blocks, in a single factorial scheme. The treatment factor was composed of the following resistance inducers [without inducer, selenium (Se), silicon (Si), acibenzolar-s-methyl (ASM), methyl jasmonate (MeJa), thiamethoxam (TMT) and imidacloprid (IMI)]. In the laboratory, the design used was the same as that established in the field, but in a two-factorial scheme, where factor A was composed of the same inducers and factor B, for the storage period [zero (fruits that were not submitted to storage) and 30 days (Cold chamber 5±1°C, relative humidity 85 to 95%)], with simulation of the commercialization time (7 days at 20±1°C). The following analysis were performed: coloration (L *, a *, b * and hue), fresh mass loss, rot index, soluble solids (SS), pH, titratable acidity (TA), SS/TA ratio, ascorbic acid, phenolic compounds and antioxidant capacity. The application of resistance inducers reduces the percentage of fresh mass loss and fruit rot after 30 days of refrigerated storage. Inducers keep phenolic compounds and antioxidant capacity, both in pulp and fruit peel, over the storage period. The inducers Si, MeJa and IMI provide phytochemicals improvement, when compared to the control.
DOI: 10.6084/m9.figshare.7898834
title: Reproductive biology of a viviparous lizard (Mabuya dorsivittata) from the subtropical Wet Chaco of Argentina: geographical variations in response to local environmental pressures

description: Herein we studied the reproductive biology of a viviparous lizard (Mabuya dorsivittata) from the Wet Chaco region (northeastern Argentina) and compared the results with other populations from the Espinal (central Argentina) and the Atlantic Forest (southeastern Brazil), and with other Neotropical species of Mabuya to better understand the possible causes of its reproductive phenotype variation. Males and females of M. dorsivittata from the Wet Chaco exhibited associated, seasonal, and annual reproductive cycles. Spermatogenic activity related positively to a lengthening photoperiod reaching maximum activity in late spring (December). Females displayed an extended gestation period of 11 months, from mid-summer (February) to late spring or early summer (December) when births occur. Embryonic development was associated with temperature and historical rainfall. Litter size ranged from 3 to 8 (mean = 5.3 ± 1.3 SD) and increased with body size and body mass of females. Fat-body mass varied seasonally and was inversely correlated with spermatogenesis and to embryonic development. Females were larger in body size and interlimb length, and smaller in head length than males. We observed interpopulational differences in minimum body size, litter size, and timing of birth, probably as a result of phenotypic plasticity, genetic divergence or both.
DOI: 10.6084/m9.figshare.7898837.v1
title: Relationship between ventilation heterogeneity and exercise intolerance in adults with sickle cell anemia

description: Sickle cell anemia (SCA) causes dysfunction of multiple organs, with pulmonary involvement as a major cause of mortality. Recently, there has been growing interest in the nitrogen single-breath washout (N2SBW) test, which is able to detect ventilation heterogeneity and small airway disease when the results of other pulmonary function tests (PFTs) are still normal. Thus, the objectives of the present study were to assess the heterogeneity in the ventilation distribution in adults with SCA and to determine the association between the ventilation distribution and the clinical, cardiovascular, and radiological findings. This cross-sectional study included 38 adults with SCA who underwent PFTs, echocardiography, computed tomography (CT), and 6-min walk test. To evaluate the ventilation heterogeneity, the patients were categorized according to the phase III slope of the N2SBW (SIIIN2). Compared with adults with lower SIIIN2 values, adults with higher SIIIN2 values showed lower hemoglobin levels (P=0.048), a history of acute chest syndrome (P=0.001), an elevated tricuspid regurgitation velocity (P=0.039), predominance of a reticular pattern in the CT (P=0.002), a shorter 6-min walking distance (6MWD) (P=0.002), and lower peripheral oxygen saturation (SpO2) after exercise (P=0.03). SIIIN2 values correlated significantly with hemoglobin (rs=-0.344; P=0.034), forced vital capacity (rs=-0.671; P&lt;0.0001), diffusing capacity for carbon monoxide (rs=-0.376; P=0.019), 6MWD (rs=-0.554; P=0.0003), and SpO2 after exercise (P=0.040). Heterogeneity in the ventilation distribution is one of the most common pulmonary dysfunctions in adults with SCA. Moreover, relationships exist between ventilation heterogeneity, worsening of pulmonary structural damage, and reduced tolerance for exercise.
DOI: 10.6084/m9.figshare.7898840.v1
title: Serum microRNA-30c levels are correlated with disease progression in Xinjiang Uygur patients with chronic hepatitis B

description: We aimed to investigate the potential role and mechanism of microRNA-30c (miR-30c) in the pathological development of chronic hepatitis B (CHB). The serum levels of miR-30c in hepatitis B virus (HBV) carrier Xinjiang Uygur patients with inactive, low-replicative, high-replicative and HBe antigen-positive CHB were investigated. HepG2 cells were co-transfected with pHBV1.3 and miR-30c mimic or inhibitor or scramble RNA. The effects of miR-30c dysregulation on HBV replication and gene expression, cell proliferation and cell cycle were then investigated. miR-30c was down-regulated in Xinjiang Uygur patients with CHB compared to healthy controls and its expression level discriminated HBV carrier patients with inactive, low-replicative, high-replicative and HBe antigen-positive risk for disease progression. Overexpression of miR-30c significantly inhibited HBV replication and the expressions of HBV pgRNA, capsid-associated virus DNA and Hbx in hepatoma cells. Moreover, overexpression of miR-30c significantly inhibited cell proliferation and delayed G1/S phase transition in hepatoma cells. Opposite effects were obtained after suppression of miR-30c. Our results indicate that miR-30c was down-regulated in Xinjiang Uygur patients with CHB, and miR-30c levels could serve as a marker for risk stratification of HBV infection. Down-regulation of miR-30c may result in the progression of CHB via promoting HBV replication and cell proliferation.
DOI: 10.6084/m9.figshare.7898843.v1
title: Postoperative Atrial Fibrillation: Evaluation of its Economic Impact on the Costs of Cardiac Surgery

description: Abstract Objective: The objective of this study was to calculate the direct costs of postoperative atrial fibrillation (POAF) in a high-complexity cardiovascular hospital. Methods: We performed a cost analysis with a pairwise-matched design. Twenty-two patients with POAF and 22 patients without this complication were included. Pair-matching was performed (1:1) based on the following criteria: identical type of surgery, similar EuroSCORE II values, and absence of any other postoperative complication. Results: The total hospital cost was significantly higher in the POAF group than in the non-POAF group (US$ 10,880 [± 2,688] vs. US$ 8,856 [± 1,782], respectively, for each patient; P=0.005). This difference was attributable to postoperative costs (US$ 3,103 [± 1,552] vs. US$ 1,238 [± 429]; P=0.0001) for patients with or without POAF, respectively. The median postoperative lengths of stay were 9 (range 5-17) and 5 (3-9) days for patients with and without POAF (P=0.032), respectively. Preoperatively, no differences were found in the EuroSCORE II values (median 1.7 vs. 1.6, respectively; P=0.91) or direct costs (US$ 1,127 vs. US$ 1,063, respectively; P=0.56) between POAF and non-POAF groups. Conclusion: POAF generates a high economic burden in the overall costs of cardiac surgery, and our results reveal the differential contribution of each of the evaluated factors. This information, which was previously unavailable in this setting, is essential for the development of more effective prevention strategies.
DOI: 10.6084/m9.figshare.7898822
title: The research and cataloguing methodology of the rooms of the Rui Barbosa Historic House Museum

description: ABSTRACT This article shows the results of the study “Development of methodology for cataloging the rooms of a historic house museum, understood as museum objects”, developed within the scope of the Incentive Program for the Production of Technical and Scientific Knowledge in the Culture Area of the House of Rui Barbosa Foundation. The study methodology included a literature review and application of questionnaires. Firstly, we discussed the historic house museum category and the relevance of studying domestic interiors in this context; then, we discussed the understanding of the rooms as museum objects and the importance of recording the social trajectory of museological artifacts. In the fourth section of this article, we present and reflect on the collection of object rooms of the Rui Barbosa Historic House, which is located in a construction built in 1850 that served as residence to Rui Barbosa and his family between 1895 and 1923. The field research included questionnaires with professionals of the historic house museum and with the public of the Rui Barbosa Historic House Museum. In the first case, the objective was to investigate the methodologies adopted for elaborating the museum documentation; the research with the public sought to include the visitors’ demands and perceptions regarding the house museum. After such reflections and investigations, elaborating the cataloguing methodology for the rooms was possible, which includes the steps of observation and reading of the house compartments, the analysis of their properties, and the filling of the catalogue records. Up until now, the research has demonstrated the possible novelty of this methodology, which has potential to be adapted to the realities of other historic house museums.
DOI: 10.6084/m9.figshare.7898831
title: Experimental analysis of load capacity in beams with steel fiber reinforcement on the compression face

description: Abstract The use of steel fibers in the concrete is mainly aimed at increasing the post-peak toughness, due to the adhesion of the fibers to the cementitious matrix. However, there are several typologies of steel fibers, and the main differences are in the form (relation between length and diameter), fiber geometry, and the characterization between macrofibers and microfibers, which generally serve to reduce macrocracking and microcracking, respectively. In this context, this work evaluated the use of microfibers (20 kg/m³ or volume equal to 0.26% (Vf) of concrete volume), macrofibers (20 kg/m³ or Vf = 0.26%) and hybridization (10 kg/m³) + macrofibers (10 kg/m³) inserted in a high strength concrete (fc = 80 MPa). Two types of steel fibers were used: macrofibers with a diameter of 0.75 mm and a length of 60 mm (a form factor of 80); and microfibers with a diameter of 200 μm and a length of 13 mm (a form factor of 65). The fibers were used in concrete to act as a reinforcement on the compression face of reinforced beams (12×20×160cm), and the mechanical characteristics of the concretes were analyzed: (i) flexural strength in prismatic specimens (10×10×35 cm), (ii) compressive strength in cylindrical specimens (20×Ø10 cm) and (iii) modulus of elasticity in cylindrical specimens (20×Ø10 cm). Analysis of the results showed that compressive strength increased by approximately 8% for all the compositions with fibers compared with concrete without fibers. Similar behavior was verified for the modulus of elasticity. In the prismatic specimens (10×10×35 cm) an increase in toughness was observed, with the macrofibers performing better. In beams measuring 12×20×160 cm, an increase in bearing capacity was verified regarding cracking time and plastic rotation, with the best result also obtained using macrofibers. Overall, it can be concluded that the application of reinforcement with steel fibers in the compression face of beams was efficient, even though it did not present a significant increase in compressive strength, a fact that could be correlated with the reduced volume of fibers used.
DOI: 10.6084/m9.figshare.7898831.v1
title: Experimental analysis of load capacity in beams with steel fiber reinforcement on the compression face

description: Abstract The use of steel fibers in the concrete is mainly aimed at increasing the post-peak toughness, due to the adhesion of the fibers to the cementitious matrix. However, there are several typologies of steel fibers, and the main differences are in the form (relation between length and diameter), fiber geometry, and the characterization between macrofibers and microfibers, which generally serve to reduce macrocracking and microcracking, respectively. In this context, this work evaluated the use of microfibers (20 kg/m³ or volume equal to 0.26% (Vf) of concrete volume), macrofibers (20 kg/m³ or Vf = 0.26%) and hybridization (10 kg/m³) + macrofibers (10 kg/m³) inserted in a high strength concrete (fc = 80 MPa). Two types of steel fibers were used: macrofibers with a diameter of 0.75 mm and a length of 60 mm (a form factor of 80); and microfibers with a diameter of 200 μm and a length of 13 mm (a form factor of 65). The fibers were used in concrete to act as a reinforcement on the compression face of reinforced beams (12×20×160cm), and the mechanical characteristics of the concretes were analyzed: (i) flexural strength in prismatic specimens (10×10×35 cm), (ii) compressive strength in cylindrical specimens (20×Ø10 cm) and (iii) modulus of elasticity in cylindrical specimens (20×Ø10 cm). Analysis of the results showed that compressive strength increased by approximately 8% for all the compositions with fibers compared with concrete without fibers. Similar behavior was verified for the modulus of elasticity. In the prismatic specimens (10×10×35 cm) an increase in toughness was observed, with the macrofibers performing better. In beams measuring 12×20×160 cm, an increase in bearing capacity was verified regarding cracking time and plastic rotation, with the best result also obtained using macrofibers. Overall, it can be concluded that the application of reinforcement with steel fibers in the compression face of beams was efficient, even though it did not present a significant increase in compressive strength, a fact that could be correlated with the reduced volume of fibers used.
DOI: 10.6084/m9.figshare.7898834.v1
title: Reproductive biology of a viviparous lizard (Mabuya dorsivittata) from the subtropical Wet Chaco of Argentina: geographical variations in response to local environmental pressures

description: Herein we studied the reproductive biology of a viviparous lizard (Mabuya dorsivittata) from the Wet Chaco region (northeastern Argentina) and compared the results with other populations from the Espinal (central Argentina) and the Atlantic Forest (southeastern Brazil), and with other Neotropical species of Mabuya to better understand the possible causes of its reproductive phenotype variation. Males and females of M. dorsivittata from the Wet Chaco exhibited associated, seasonal, and annual reproductive cycles. Spermatogenic activity related positively to a lengthening photoperiod reaching maximum activity in late spring (December). Females displayed an extended gestation period of 11 months, from mid-summer (February) to late spring or early summer (December) when births occur. Embryonic development was associated with temperature and historical rainfall. Litter size ranged from 3 to 8 (mean = 5.3 ± 1.3 SD) and increased with body size and body mass of females. Fat-body mass varied seasonally and was inversely correlated with spermatogenesis and to embryonic development. Females were larger in body size and interlimb length, and smaller in head length than males. We observed interpopulational differences in minimum body size, litter size, and timing of birth, probably as a result of phenotypic plasticity, genetic divergence or both.
DOI: 10.6084/m9.figshare.7898819
title: Relationship between matrix metalloproteinases and the occurrence and development of ovarian cancer

description: Ovarian cancer is one of the most malignant genital cancers, with a high mortality rate. Many researchers have suggested that matrix metalloproteinases (MMPs) have remarkably high expression in ovarian cancer tissues. MMPs are considered to be related to the occurrence, development, invasion and metastasis of ovarian cancer. Moreover, some studies have discovered that the unbalance between MMPs and tissue inhibitor of metalloproteinases (TIMPs) are associated with the malignant phenotype of tumors. This review summarizes the latest research progress of MMPs in ovarian cancer. The investigation of MMP mechanism in ovarian cancer will facilitate the development of effective anti-tumor drugs, and thereby improve the survival rate of patients with ovarian cancer.