cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.7483/opendata.cms.zy46.evef
title: /DYTypeIHeavyN-DFmix_Dilepton_MN90_TuneCP5_13TeV-amcatnlo-pythia8/RunIISummer20UL16MiniAODv2-106X_mcRun2_asymptotic_v17-v2/MINIAODSIM
DOI: 10.7483/opendata.cms.tqxs.29ir
title: /DYTypeIHeavyN-DFmix_Dilepton_MN90_TuneCP5_13TeV-amcatnlo-pythia8/RunIISummer20UL16NanoAODv9-106X_mcRun2_asymptotic_v17-v2/NANOAODSIM
DOI: 10.7483/opendata.cms.z3w5.wsxa
title: /DYTypeIHeavyN-DFmix_Dilepton_MN95_TuneCP5_13TeV-amcatnlo-pythia8/RunIISummer20UL16MiniAODv2-106X_mcRun2_asymptotic_v17-v2/MINIAODSIM
DOI: 10.7483/opendata.cms.w42d.o7ct
title: /DYTypeIHeavyN-DFmix_Dilepton_MN95_TuneCP5_13TeV-amcatnlo-pythia8/RunIISummer20UL16NanoAODv9-106X_mcRun2_asymptotic_v17-v2/NANOAODSIM
DOI: 10.7483/opendata.cms.ylse.h92i
title: /DYTypeIHeavyN-SFmix_Dilepton_MN1000_TuneCP5_13TeV-amcatnlo-pythia8/RunIISummer20UL16MiniAODv2-106X_mcRun2_asymptotic_v17-v2/MINIAODSIM
DOI: 10.7483/opendata.cms.1o8a.9zjv
title: /DYTypeIHeavyN-SFmix_Dilepton_MN1000_TuneCP5_13TeV-amcatnlo-pythia8/RunIISummer20UL16NanoAODv9-106X_mcRun2_asymptotic_v17-v2/NANOAODSIM
DOI: 10.7483/opendata.cms.de2k.6bbv
title: /DYTypeIHeavyN-SFmix_Dilepton_MN100_TuneCP5_13TeV-amcatnlo-pythia8/RunIISummer20UL16MiniAODv2-106X_mcRun2_asymptotic_v17-v2/MINIAODSIM
DOI: 10.7483/opendata.cms.wb2p.g3ly
title: /DYTypeIHeavyN-SFmix_Dilepton_MN100_TuneCP5_13TeV-amcatnlo-pythia8/RunIISummer20UL16NanoAODv9-106X_mcRun2_asymptotic_v17-v2/NANOAODSIM
DOI: 10.7483/opendata.cms.jcze.eoef
title: /DYTypeIHeavyN-SFmix_Dilepton_MN1100_TuneCP5_13TeV-amcatnlo-pythia8/RunIISummer20UL16MiniAODv2-106X_mcRun2_asymptotic_v17-v2/MINIAODSIM
DOI: 10.7483/opendata.cms.r83z.8tw2
title: /DYTypeIHeavyN-SFmix_Dilepton_MN1100_TuneCP5_13TeV-amcatnlo-pythia8/RunIISummer20UL16NanoAODv9-106X_mcRun2_asymptotic_v17-v2/NANOAODSIM
DOI: 10.7483/opendata.cms.bclq.eyn5
title: /DYTypeIHeavyN-SFmix_Dilepton_MN1200_TuneCP5_13TeV-amcatnlo-pythia8/RunIISummer20UL16MiniAODv2-106X_mcRun2_asymptotic_v17-v2/MINIAODSIM
DOI: 10.7483/opendata.cms.uf0t.ff0w
title: /DYTypeIHeavyN-SFmix_Dilepton_MN1200_TuneCP5_13TeV-amcatnlo-pythia8/RunIISummer20UL16NanoAODv9-106X_mcRun2_asymptotic_v17-v2/NANOAODSIM
DOI: 10.7483/opendata.cms.rs3e.e99i
title: /DYTypeIHeavyN-SFmix_Dilepton_MN125_TuneCP5_13TeV-amcatnlo-pythia8/RunIISummer20UL16MiniAODv2-106X_mcRun2_asymptotic_v17-v2/MINIAODSIM
DOI: 10.7483/opendata.cms.t3mi.rasq
title: /DYTypeIHeavyN-SFmix_Dilepton_MN125_TuneCP5_13TeV-amcatnlo-pythia8/RunIISummer20UL16NanoAODv9-106X_mcRun2_asymptotic_v17-v2/NANOAODSIM
DOI: 10.7483/opendata.cms.3fln.g10h
title: /DYTypeIHeavyN-SFmix_Dilepton_MN1300_TuneCP5_13TeV-amcatnlo-pythia8/RunIISummer20UL16MiniAODv2-106X_mcRun2_asymptotic_v17-v2/MINIAODSIM
DOI: 10.7483/opendata.cms.sher.w3rl
title: /DYTypeIHeavyN-SFmix_Dilepton_MN1300_TuneCP5_13TeV-amcatnlo-pythia8/RunIISummer20UL16NanoAODv9-106X_mcRun2_asymptotic_v17-v2/NANOAODSIM
DOI: 10.7483/opendata.cms.ckzp.khg3
title: /DYTypeIHeavyN-SFmix_Dilepton_MN1500_TuneCP5_13TeV-amcatnlo-pythia8/RunIISummer20UL16MiniAODv2-106X_mcRun2_asymptotic_v17-v2/MINIAODSIM
DOI: 10.7483/opendata.cms.x8n7.dorg
title: /DYTypeIHeavyN-SFmix_Dilepton_MN1500_TuneCP5_13TeV-amcatnlo-pythia8/RunIISummer20UL16NanoAODv9-106X_mcRun2_asymptotic_v17-v2/NANOAODSIM
DOI: 10.7483/opendata.cms.ltfi.zqr9
title: /DYTypeIHeavyN-SFmix_Dilepton_MN150_TuneCP5_13TeV-amcatnlo-pythia8/RunIISummer20UL16MiniAODv2-106X_mcRun2_asymptotic_v17-v2/MINIAODSIM
DOI: 10.7483/opendata.cms.l41i.l76t
title: /DYTypeIHeavyN-SFmix_Dilepton_MN150_TuneCP5_13TeV-amcatnlo-pythia8/RunIISummer20UL16NanoAODv9-106X_mcRun2_asymptotic_v17-v2/NANOAODSIM
DOI: 10.7483/opendata.cms.dc3n.dbwh
title: /DYTypeIHeavyN-SFmix_Dilepton_MN1700_TuneCP5_13TeV-amcatnlo-pythia8/RunIISummer20UL16MiniAODv2-106X_mcRun2_asymptotic_v17-v2/MINIAODSIM
DOI: 10.7483/opendata.cms.mo1n.90sg
title: /DYTypeIHeavyN-SFmix_Dilepton_MN1700_TuneCP5_13TeV-amcatnlo-pythia8/RunIISummer20UL16NanoAODv9-106X_mcRun2_asymptotic_v17-v2/NANOAODSIM
DOI: 10.7483/opendata.cms.1tgz.xcsy
title: /DYTypeIHeavyN-SFmix_Dilepton_MN2000_TuneCP5_13TeV-amcatnlo-pythia8/RunIISummer20UL16MiniAODv2-106X_mcRun2_asymptotic_v17-v2/MINIAODSIM
DOI: 10.7483/opendata.cms.t0z1.5px7
title: /DYTypeIHeavyN-SFmix_Dilepton_MN2000_TuneCP5_13TeV-amcatnlo-pythia8/RunIISummer20UL16NanoAODv9-106X_mcRun2_asymptotic_v17-v2/NANOAODSIM
DOI: 10.7483/opendata.cms.p5yx.43na
title: /DYTypeIHeavyN-SFmix_Dilepton_MN200_TuneCP5_13TeV-amcatnlo-pythia8/RunIISummer20UL16MiniAODv2-106X_mcRun2_asymptotic_v17-v2/MINIAODSIM
DOI: 10.7483/opendata.cms.bl69.wxzl
title: /DYTypeIHeavyN-SFmix_Dilepton_MN200_TuneCP5_13TeV-amcatnlo-pythia8/RunIISummer20UL16NanoAODv9-106X_mcRun2_asymptotic_v17-v2/NANOAODSIM
DOI: 10.7483/opendata.cms.ad2h.eeup
title: /DYTypeIHeavyN-SFmix_Dilepton_MN2500_TuneCP5_13TeV-amcatnlo-pythia8/RunIISummer20UL16MiniAODv2-106X_mcRun2_asymptotic_v17-v2/MINIAODSIM
DOI: 10.7483/opendata.cms.b1qj.qct0
title: /DYTypeIHeavyN-SFmix_Dilepton_MN2500_TuneCP5_13TeV-amcatnlo-pythia8/RunIISummer20UL16NanoAODv9-106X_mcRun2_asymptotic_v17-v2/NANOAODSIM
DOI: 10.7483/opendata.cms.r1r0.xudz
title: /DYTypeIHeavyN-SFmix_Dilepton_MN250_TuneCP5_13TeV-amcatnlo-pythia8/RunIISummer20UL16MiniAODv2-106X_mcRun2_asymptotic_v17-v2/MINIAODSIM
DOI: 10.7483/opendata.cms.epth.7iei
title: /DYTypeIHeavyN-SFmix_Dilepton_MN250_TuneCP5_13TeV-amcatnlo-pythia8/RunIISummer20UL16NanoAODv9-106X_mcRun2_asymptotic_v17-v2/NANOAODSIM
DOI: 10.7483/opendata.cms.trr1.wq7y
title: /DYTypeIHeavyN-SFmix_Dilepton_MN3000_TuneCP5_13TeV-amcatnlo-pythia8/RunIISummer20UL16MiniAODv2-106X_mcRun2_asymptotic_v17-v2/MINIAODSIM
DOI: 10.7483/opendata.cms.ycyy.358h
title: /DYTypeIHeavyN-SFmix_Dilepton_MN3000_TuneCP5_13TeV-amcatnlo-pythia8/RunIISummer20UL16NanoAODv9-106X_mcRun2_asymptotic_v17-v2/NANOAODSIM
DOI: 10.7483/opendata.cms.3xwp.2i9o
title: /DYTypeIHeavyN-SFmix_Dilepton_MN300_TuneCP5_13TeV-amcatnlo-pythia8/RunIISummer20UL16MiniAODv2-106X_mcRun2_asymptotic_v17-v2/MINIAODSIM
DOI: 10.7483/opendata.cms.n63x.fmjn
title: /DYTypeIHeavyN-SFmix_Dilepton_MN300_TuneCP5_13TeV-amcatnlo-pythia8/RunIISummer20UL16NanoAODv9-106X_mcRun2_asymptotic_v17-v2/NANOAODSIM
DOI: 10.7483/opendata.cms.arak.4eqs
title: /DYTypeIHeavyN-SFmix_Dilepton_MN400_TuneCP5_13TeV-amcatnlo-pythia8/RunIISummer20UL16MiniAODv2-106X_mcRun2_asymptotic_v17-v2/MINIAODSIM
DOI: 10.7483/opendata.cms.2n6w.24zs
title: /DYTypeIHeavyN-SFmix_Dilepton_MN400_TuneCP5_13TeV-amcatnlo-pythia8/RunIISummer20UL16NanoAODv9-106X_mcRun2_asymptotic_v17-v2/NANOAODSIM
DOI: 10.7483/opendata.cms.mbk6.kcgy
title: /DYTypeIHeavyN-SFmix_Dilepton_MN500_TuneCP5_13TeV-amcatnlo-pythia8/RunIISummer20UL16MiniAODv2-106X_mcRun2_asymptotic_v17-v2/MINIAODSIM
DOI: 10.7483/opendata.cms.5o1i.mgsb
title: /DYTypeIHeavyN-SFmix_Dilepton_MN500_TuneCP5_13TeV-amcatnlo-pythia8/RunIISummer20UL16NanoAODv9-106X_mcRun2_asymptotic_v17-v2/NANOAODSIM
DOI: 10.7483/opendata.cms.97ad.yb9v
title: /DYTypeIHeavyN-SFmix_Dilepton_MN600_TuneCP5_13TeV-amcatnlo-pythia8/RunIISummer20UL16MiniAODv2-106X_mcRun2_asymptotic_v17-v2/MINIAODSIM
DOI: 10.7483/opendata.cms.u1gp.jece
title: /DYTypeIHeavyN-SFmix_Dilepton_MN600_TuneCP5_13TeV-amcatnlo-pythia8/RunIISummer20UL16NanoAODv9-106X_mcRun2_asymptotic_v17-v2/NANOAODSIM
DOI: 10.7483/opendata.cms.hlra.dcj5
title: /DYTypeIHeavyN-SFmix_Dilepton_MN700_TuneCP5_13TeV-amcatnlo-pythia8/RunIISummer20UL16MiniAODv2-106X_mcRun2_asymptotic_v17-v2/MINIAODSIM
DOI: 10.7483/opendata.cms.7lw2.07ux
title: /DYTypeIHeavyN-SFmix_Dilepton_MN700_TuneCP5_13TeV-amcatnlo-pythia8/RunIISummer20UL16NanoAODv9-106X_mcRun2_asymptotic_v17-v2/NANOAODSIM
DOI: 10.15468/dl.8eqbmc
title: Occurrence Download

description: A dataset containing 3 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Geometry POLYGON((-17.42644 27.87359,-15.46044 27.87359,-15.46044 28.65965,-17.42644 28.65965,-17.42644 27.87359))",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 "TaxonKey is Orchis canariensis Lindl.",
 "Year 2024-2024"
 ]
}

 The dataset includes 3 records from 2 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0065509-241126133413365/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.7483/opendata.cms.maev.pkld
title: /DYTypeIHeavyN-SFmix_Dilepton_MN800_TuneCP5_13TeV-amcatnlo-pythia8/RunIISummer20UL16MiniAODv2-106X_mcRun2_asymptotic_v17-v2/MINIAODSIM
DOI: 10.7483/opendata.cms.aa9x.sexw
title: /DYTypeIHeavyN-SFmix_Dilepton_MN800_TuneCP5_13TeV-amcatnlo-pythia8/RunIISummer20UL16NanoAODv9-106X_mcRun2_asymptotic_v17-v2/NANOAODSIM
DOI: 10.7483/opendata.cms.75jn.2599
title: /DYTypeIHeavyN-SFmix_Dilepton_MN85_TuneCP5_13TeV-amcatnlo-pythia8/RunIISummer20UL16MiniAODv2-106X_mcRun2_asymptotic_v17-v2/MINIAODSIM
DOI: 10.5281/zenodo.14635357
title: MADANIYAT TUSHUNCHASINING TARIXIY ASOSLARINI ANGLASH ORQALI MA'NAVIY MADANIYATNI RIVOJLANTIRISH

description: Madaniyat tushunchasining tarixiy asoslarini anglash insoniyatning ma’naviy taraqqiyotidagi asosiy omillardan biri hisoblanadi. Tarixiy ildizlarni o‘rganish orqali madaniy qadriyatlarning shakllanish jarayonini anglash va ularni zamonaviy hayotga tatbiq etish imkoniyati yaratiladi. Ushbu jarayon milliy o‘zlikni saqlash, madaniy xilma-xillikni qadrlash va ma’naviy boylikni rivojlantirishda muhim o‘rin tutadi.
DOI: 10.5281/zenodo.14635358
title: MADANIYAT TUSHUNCHASINING TARIXIY ASOSLARINI ANGLASH ORQALI MA'NAVIY MADANIYATNI RIVOJLANTIRISH

description: Madaniyat tushunchasining tarixiy asoslarini anglash insoniyatning ma’naviy taraqqiyotidagi asosiy omillardan biri hisoblanadi. Tarixiy ildizlarni o‘rganish orqali madaniy qadriyatlarning shakllanish jarayonini anglash va ularni zamonaviy hayotga tatbiq etish imkoniyati yaratiladi. Ushbu jarayon milliy o‘zlikni saqlash, madaniy xilma-xillikni qadrlash va ma’naviy boylikni rivojlantirishda muhim o‘rin tutadi.
DOI: 10.15468/dl.ejytb5
title: Occurrence Download

description: A dataset containing 345 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Mustela erminea Linnaeus, 1758",
 "Country is New Zealand",
 "Year is greater than or equal to 1500"
 ]
}

 The dataset includes 345 records from 9 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0065510-241126133413365/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.6084/m9.figshare.28099432
title: Concurrent severe fever with thrombocytopenia syndrome virus outbreaks on multiple fox farms, China, 2023

description: The role of farmed animals in the viral spillover from wild animals to humans is of growing importance. Between July and September of 2023 infectious disease outbreaks were reported on six Arctic fox (<i>Vulpes lagopus</i>) farms in Shandong and Liaoning provinces, China, which lasted for 2–3 months and resulted in tens to hundreds of fatalities per farm. Severe Fever with Thrombocytopenia Syndrome Virus (SFTSV) was identified in tissue/organ and swab samples from all the 13 foxes collected from these farms. These animals exhibited loss of appetite and weight loss, finally resulting in death. In autopsy and histopathology, prominently enlarged spleens and extensive multi-organ hemorrhage were observed, respectively, indicating severe systemic effects. Viral loads were detected in various tissues/organs, including brains from 9 of the 10 foxes. SFTSV was also detected in serum, anal swabs, as well as in environmental samples, including residual food in troughs used by dying foxes in follow-up studies at two farms. The 13 newly sequenced SFTSV genomes shared &gt;99.43% nucleotide identity with human strains from China. Phylogenetic analyses showed that the 13 sequences belonged to three genotypes, and that two sequences from Liaoning were genomic reassortants, indicative of multiple sources and introduction events. This study provides the first evidence of SFTSV infection, multi-tissue tropism, and pathogenicity in farmed foxes, representing an expanded virus host range. However, the widespread circulation of different genotypes of SFTSV in farmed animals from different provinces and the diverse transmission routes, highlight its increasing and noticeable public health risk in China.
DOI: 10.6084/m9.figshare.28099379
title: To be or not to be phosphorylated: understanding the role of Ebola virus nucleoprotein in the dynamic interplay with the transcriptional activator VP30 and the host phosphatase PP2A-B56

description: Ebola virus (EBOV) transcription is essentially regulated via dynamic dephosphorylation of its viral transcription activator VP30 by the host phosphatase PP2A. The nucleoprotein NP has emerged as a third key player in the regulation of this process by recruiting both the regulatory subunit B56 of PP2A and its substrate VP30 to initiate VP30 dephosphorylation and hence viral transcription. Both binding sites are located in close proximity to each other in NP’s C-terminal-disordered region. This study investigates NP’s role in VP30 dephosphorylation and transcription activation, focussing on the spatial requirements of NP’s binding sites. Increasing the distance between PP2A-B56 and VP30 at the NP interface revealed that close spatial and orientational contact is necessary for efficient VP30 dephosphorylation and viral transcription. Longer distances were lethal for recombinant EBOV except when a compensatory mutation, NP-T603I, occurred. This mutation, located between the NP binding sites for PP2A-B56 and VP30, fully restored functionality. Mass spectrometry showed that T603 is phosphorylated in recEBOV-NPwt virions. Mutational analysis indicated that T603I facilitates VP30 dephosphorylation in otherwise lethal recEBOV and that dynamic phosphorylation of NP-T603 is important for efficient primary viral transcription in the WT context. These findings emphasize the critical and evolutionarily pressured interplay between VP30 and PP2A-B56 within the NP C-terminal-disordered region and highlight the important role of NP on the regulation of viral transcription during the EBOV life cycle.
DOI: 10.6084/m9.figshare.28099432.v2
title: Concurrent severe fever with thrombocytopenia syndrome virus outbreaks on multiple fox farms, China, 2023

description: The role of farmed animals in the viral spillover from wild animals to humans is of growing importance. Between July and September of 2023 infectious disease outbreaks were reported on six Arctic fox (<i>Vulpes lagopus</i>) farms in Shandong and Liaoning provinces, China, which lasted for 2–3 months and resulted in tens to hundreds of fatalities per farm. Severe Fever with Thrombocytopenia Syndrome Virus (SFTSV) was identified in tissue/organ and swab samples from all the 13 foxes collected from these farms. These animals exhibited loss of appetite and weight loss, finally resulting in death. In autopsy and histopathology, prominently enlarged spleens and extensive multi-organ hemorrhage were observed, respectively, indicating severe systemic effects. Viral loads were detected in various tissues/organs, including brains from 9 of the 10 foxes. SFTSV was also detected in serum, anal swabs, as well as in environmental samples, including residual food in troughs used by dying foxes in follow-up studies at two farms. The 13 newly sequenced SFTSV genomes shared &gt;99.43% nucleotide identity with human strains from China. Phylogenetic analyses showed that the 13 sequences belonged to three genotypes, and that two sequences from Liaoning were genomic reassortants, indicative of multiple sources and introduction events. This study provides the first evidence of SFTSV infection, multi-tissue tropism, and pathogenicity in farmed foxes, representing an expanded virus host range. However, the widespread circulation of different genotypes of SFTSV in farmed animals from different provinces and the diverse transmission routes, highlight its increasing and noticeable public health risk in China.
DOI: 10.6084/m9.figshare.28099379.v2
title: To be or not to be phosphorylated: understanding the role of Ebola virus nucleoprotein in the dynamic interplay with the transcriptional activator VP30 and the host phosphatase PP2A-B56

description: Ebola virus (EBOV) transcription is essentially regulated via dynamic dephosphorylation of its viral transcription activator VP30 by the host phosphatase PP2A. The nucleoprotein NP has emerged as a third key player in the regulation of this process by recruiting both the regulatory subunit B56 of PP2A and its substrate VP30 to initiate VP30 dephosphorylation and hence viral transcription. Both binding sites are located in close proximity to each other in NP’s C-terminal-disordered region. This study investigates NP’s role in VP30 dephosphorylation and transcription activation, focussing on the spatial requirements of NP’s binding sites. Increasing the distance between PP2A-B56 and VP30 at the NP interface revealed that close spatial and orientational contact is necessary for efficient VP30 dephosphorylation and viral transcription. Longer distances were lethal for recombinant EBOV except when a compensatory mutation, NP-T603I, occurred. This mutation, located between the NP binding sites for PP2A-B56 and VP30, fully restored functionality. Mass spectrometry showed that T603 is phosphorylated in recEBOV-NPwt virions. Mutational analysis indicated that T603I facilitates VP30 dephosphorylation in otherwise lethal recEBOV and that dynamic phosphorylation of NP-T603 is important for efficient primary viral transcription in the WT context. These findings emphasize the critical and evolutionarily pressured interplay between VP30 and PP2A-B56 within the NP C-terminal-disordered region and highlight the important role of NP on the regulation of viral transcription during the EBOV life cycle.
DOI: 10.6084/m9.figshare.28099432.v1
title: Concurrent Severe Fever with Thrombocytopenia Syndrome Virus Outbreaks on Multiple Fox Farms, China, 2023

description: The role of farmed animals in the viral spillover from wild animals to humans is of growing importance. Between July and September of 2023 infectious disease outbreaks were reported on six Arctic fox (<i>Vulpes lagopus</i>) farms in Shandong and Liaoning provinces, China, which lasted for 2-3 months and resulted in tens to hundreds of fatalities per farm. Severe Fever with Thrombocytopenia Syndrome Virus (SFTSV) was identified in tissue/organ and swab samples from all the 13 foxes collected from these farms. These animals exhibited loss of appetite and weight loss, finally resulting in death. In autopsy and histopathology, prominently enlarged spleens and extensive multi-organ hemorrhage were observed, respectively, indicating severe systemic effects. Viral loads were detected in various tissues/organs, including brains from 12 of the 13 foxes. SFTSV was also detected in serum, anal swabs, as well as in environmental samples, including residual food in troughs used by dying foxes in two follow-up studies at two farms. The 13 newly sequenced SFTSV genomes shared &gt;99.43% nucleotide identity with human strains from China. Phylogenetic analyses showed that the 13 sequences belonged to three genotypes, and that two sequences from Liaoning were genomic reassortants, indicative of multiple sources and introduction events. This study provides the first evidence of SFTSV infection, multi-tissue tropism, and pathogenicity in farmed foxes, representing an expanded virus host range. However, the widespread circulation of different genotypes of SFTSV in farmed animals from different provinces and the diverse transmission routes, highlight its increasing and noticeable public health risk in China.
DOI: 10.6084/m9.figshare.28099379.v1
title: To be or not to be phosphorylated: Understanding the role of Ebola virus nucleoprotein in the dynamic interplay with the transcriptional activator VP30 and the host phosphatase PP2A-B56

description: Ebola virus (EBOV) transcription is essentially regulated via dynamic dephosphorylation of its viral transcription activator VP30 by the host phosphatase PP2A. The nucleoprotein NP has emerged as a third key player in the regulation of this process by recruiting both the regulatory subunit B56 of PP2A and its substrate VP30 to initiate VP30 dephosphorylation and hence viral transcription. Both binding sites are located in close proximity to each other in NP’s C-terminal disordered region. This study investigates NP’s role in VP30 dephosphorylation and transcription activation, focusing on the spatial requirements of NP’s binding sites. Increasing the distance between PP2A-B56 and VP30 at the NP interface revealed that close spatial and orientational contact is necessary for efficient VP30 dephosphorylation and viral transcription. Longer distances were lethal for recombinant EBOV except when a compensatory mutation, NP-T603I, occurred. This mutation, located between the NP binding sites for PP2A-B56 and VP30, fully restored functionality. Mass spectrometry showed that T603 is phosphorylated in recEBOV-NPwt virions. Mutational analysis indicated that T603I facilitates VP30 dephosphorylation in otherwise lethal recEBOV and that dynamic phosphorylation of NP-T603 is important for efficient primary viral transcription in the WT context. These findings emphasize the critical and evolutionarily pressured interplay between VP30 and PP2A-B56 within the NP C-terminal disordered region and highlight the important role of NP on the regulation of viral transcription during the EBOV life cycle.
DOI: 10.15468/dl.45vfaf
title: Occurrence Download

description: A dataset containing 60303 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Cantharellus cibarius Fr."
 ]
}

 The dataset includes 60303 records from 413 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0065512-241126133413365/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.e6t2rd
title: Occurrence Download

description: A dataset containing 659 species occurrences available in GBIF matching the query:
{
 "and" : [
 "BasisOfRecord is Specimen",
 "Country is Spain",
 "TaxonKey is Quercus canariensis Willd."
 ]
}

 The dataset includes 659 records from 36 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0065514-241126133413365/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.gpdkf4
title: Occurrence Download

description: A dataset containing 33879 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is one of (China, Chinese Taipei, Hong Kong)",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 "TaxonKey is Fejervarya Bolkay, 1915",
 "Year 2015-2024"
 ]
}

 The dataset includes 33879 records from 15 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0065515-241126133413365/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.