cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.9739382
title: Could Cerebrospinal Fluid Biomarkers Offer Better Predictive Value for Spinal Cord Ischaemia Than Current Neuromonitoring Techniques During Thoracoabdominal Aortic Aneurysm Repair - A Systematic Review

description: Abstract Objective: Cerebrospinal fluid (CSF) drainage is a technique that has significantly reduced the incidence of spinal cord ischaemia (SCI). We present results of a systematic review to assess the literature on this topic in relation to thoracoabdominal aortic aneurysm repair (TAAR). Methods: Major medical databases were searched to identify papers related to CSF biomarkers measured during TAAAR. Results: Fifteen papers reported measurements of CSF biomarkers with 265 patients in total. CSF biomarkers measured included S-100ß, neuron-specific endolase (NSE), lactate, glial fibrillary acidic protein A (GFPa), Tau, heat shock protein 70 and 27 (HSP70, HSP27), and proinflammatory cytokines. Lactate and S-100ß were reported the most, but did not correlate with SCI, which was also the case with NSE and TAU. GFPa showed significant CSF level rises, both intra and postoperative in patients who suffered SCI and warrants further investigation, similar results were seen with HSP70, HSP27 and IL-8. Conclusions: Although there is significant interest in this topic, there still remains a significant lack of high-quality studies investigating CSF biomarkers during TAAR to detect SCI. A large and multicentre study is required to identify the significant role of each biomarker.
DOI: 10.6084/m9.figshare.9739385
title: Effect of Opium Addiction on Postoperative Arrhythmia Among Patients Undergoing CABG operation on Cardiopulmonary Bypass

description: Abstract Objectives: Postoperative arrhythmia is an important complication of coronary artery bypass grafting (CABG) surgeries among patients. It seems that opioid usage is implicated in the pathogenesis of this condition due to its impacts on different organ systems, such as the autonomic nervous system. The present study was performed to investigate the effect of opium use on postoperative arrhythmia in patients undergoing CABG surgery. Methods: Study participants were selected via convenience sampling from patients undergoing CABG surgery in a referral hospital. Study variables, including use of inotropic drugs, vital signs monitoring parameters and postoperative arrhythmia were observed and recorded at baseline and at follow-up time after surgery. Results: Sixty-five (14.8%) patients had postoperative arrhythmia, and 104 participants were addicted. Prevalence of postoperative arrhythmia was the same among addict and non-addict patients. According to the regression analysis model, only serum level of epinephrine in operating room, heart rate and central venous pressure at baseline and 48 hours after operation are known as independent predictors of postoperative arrhythmia among study population. Conclusion: This study showed that although opium addiction increased postoperative arrhythmia among patients undergoing CABG surgery, this difference was not significant, and this association is probably mediated by other study variables.
DOI: 10.6084/m9.figshare.9739385.v1
title: Effect of Opium Addiction on Postoperative Arrhythmia Among Patients Undergoing CABG operation on Cardiopulmonary Bypass

description: Abstract Objectives: Postoperative arrhythmia is an important complication of coronary artery bypass grafting (CABG) surgeries among patients. It seems that opioid usage is implicated in the pathogenesis of this condition due to its impacts on different organ systems, such as the autonomic nervous system. The present study was performed to investigate the effect of opium use on postoperative arrhythmia in patients undergoing CABG surgery. Methods: Study participants were selected via convenience sampling from patients undergoing CABG surgery in a referral hospital. Study variables, including use of inotropic drugs, vital signs monitoring parameters and postoperative arrhythmia were observed and recorded at baseline and at follow-up time after surgery. Results: Sixty-five (14.8%) patients had postoperative arrhythmia, and 104 participants were addicted. Prevalence of postoperative arrhythmia was the same among addict and non-addict patients. According to the regression analysis model, only serum level of epinephrine in operating room, heart rate and central venous pressure at baseline and 48 hours after operation are known as independent predictors of postoperative arrhythmia among study population. Conclusion: This study showed that although opium addiction increased postoperative arrhythmia among patients undergoing CABG surgery, this difference was not significant, and this association is probably mediated by other study variables.
DOI: 10.6084/m9.figshare.9739382.v1
title: Could Cerebrospinal Fluid Biomarkers Offer Better Predictive Value for Spinal Cord Ischaemia Than Current Neuromonitoring Techniques During Thoracoabdominal Aortic Aneurysm Repair - A Systematic Review

description: Abstract Objective: Cerebrospinal fluid (CSF) drainage is a technique that has significantly reduced the incidence of spinal cord ischaemia (SCI). We present results of a systematic review to assess the literature on this topic in relation to thoracoabdominal aortic aneurysm repair (TAAR). Methods: Major medical databases were searched to identify papers related to CSF biomarkers measured during TAAAR. Results: Fifteen papers reported measurements of CSF biomarkers with 265 patients in total. CSF biomarkers measured included S-100ß, neuron-specific endolase (NSE), lactate, glial fibrillary acidic protein A (GFPa), Tau, heat shock protein 70 and 27 (HSP70, HSP27), and proinflammatory cytokines. Lactate and S-100ß were reported the most, but did not correlate with SCI, which was also the case with NSE and TAU. GFPa showed significant CSF level rises, both intra and postoperative in patients who suffered SCI and warrants further investigation, similar results were seen with HSP70, HSP27 and IL-8. Conclusions: Although there is significant interest in this topic, there still remains a significant lack of high-quality studies investigating CSF biomarkers during TAAR to detect SCI. A large and multicentre study is required to identify the significant role of each biomarker.
DOI: 10.6084/m9.figshare.9739370
title: Prevalence of anxiety and associated factors in adults

description: ABSTRACT Objective Identify the prevalence of anxiety disorders in a population sample and associated factors. Methods A cross-sectional study of population base conducted with individuals between 18 and 35 years old. Sociodemographic variables, body mass index (BMI), presence of diseases, and use of alcohol and smoke were analyzed. The anxiety disorders were verified by the clinical interview Mini International Neuropsychiatric Interview 5.0. For the analysis, was used the Chi-square test, considering a confidence interval of 95%. Results The prevalence of general anxiety was 27.4%. Agoraphobia (17.9%) and generalized anxiety disorder (14.3%) were the most prevalent. Women presented a higher prevalence of general anxiety with 32.5% when compared with man (21,3%) (p &lt; 0.001). The variables gender, years of study, income, health problems, smoking, and alcohol were associated to more than three anxiety disorders investigated (p &lt; 0,001). Conclusions The findings demonstrate that anxiety disorders are frequent in adults, being more prevalent among women. It was associated mainly with socioeconomic conditions and legal substances. Knowing the prevalence of anxiety disorders and associated factors can help health professionals to develop better diagnoses and treatments.
DOI: 10.6084/m9.figshare.9739367
title: Functional Magnetic Resonance Imaging in the Evaluation of the Elastic Properties of Ascending Aortic Aneurysm

description: Abstract Objective: To evaluate the aortic wall elasticity using the maximal rate of systolic distension (MRSD) and maximal rate of diastolic recoil (MRDR) and their correlation with the aortic size index (ASI). Methods: Forty-eight patients with thoracic aortic aneurysm were enrolled in this study. A standard magnetic resonance imaging (MRI) protocol was used to calculate MRSD and MRDR. Both MRSD and MRDR were expressed as percentile of maximal area/10-3 sec. ASI (maximal aortic diameter/body surface area) was calculated. A correlation between MRSD, MRDR, ASI, and the patient’s age was performed using regression plot. Results: A significant correlation between MRSD (t=-4,36; r2=0.29; P≤0.0001), MRDR (t=3.92; r2=0.25; P=0.0003), and ASI (25±4.33 mm/m2; range 15,48-35,14 mm/m2) is observed. As ASI increases, aortic MRSD and MRDR decrease. Such inverse correlation between MRSD, MRDR, and ASI indicates increased stiffness of the ascending aorta. A significant correlation between the patient’s age and the decrease in MRSD and MRDR is observed. Conclusion: MRSD and MRDR are significantly correlated with ASI and the patient’s age. They seem to describe properly the increasing stiffness of aortas. These two new indexes provide a promising, accessible, and reproducible approach to evaluate the biomechanical property of the aorta.
DOI: 10.6084/m9.figshare.9739358
title: A Dedicated Stitch to Allow Early Safe Mobilization Avoiding Drain-Induced Heart Injury

description: Abstract Placement of a mediastinal drain is a routine procedure following heart surgery. Postoperative bed rest is often imposed due to the fear of potential risk of drain displacement and cardiac injury. We developed an encapsulating stitch as a feasible, effective and low-cost technique, which does not require advanced surgical skills for placement. This simple, novel approach compartmentalizes the drain allowing for safe early mobilization following cardiac surgery.
DOI: 10.6084/m9.figshare.9739361
title: Why Use the Radial Artery? The Saphenous Vein is the Second Graft of Choice for CABG in Brazil

description: Abstract The saphenous vein (SV) is the most commonly used conduit for coronary artery bypass surgery (CABG) and the second conduit of choice in Brazil and many other countries. The radial artery (RA) is suggested, by some, to be superior to SV grafts, although its use in the USA declined over a 10 year period. The patency of SV grafts (SVG) is improved when the vein is harvested with minimal trauma using the no-touch (NT) technique. This improved performance is due to the preservation of the outer pedicle surrounding the SV and reduction in vascular damage that occurs when using conventional techniques (CT) of harvesting. While the patency of NT SVGs has been shown superior to the RA at 36 months in one study, data from the RADIAL trial suggests the RA to be the superior conduit. When additional data using NT SVG is included in this trial the difference in risk of graft occlusion between the RA and SV grafts dissipates with there no longer being a significant difference in patency between conduits. The importance of preserving SV structure and the impact of NT harvesting on conduit choice for CABG patients are discussed in this short review.
DOI: 10.6084/m9.figshare.9739367.v1
title: Functional Magnetic Resonance Imaging in the Evaluation of the Elastic Properties of Ascending Aortic Aneurysm

description: Abstract Objective: To evaluate the aortic wall elasticity using the maximal rate of systolic distension (MRSD) and maximal rate of diastolic recoil (MRDR) and their correlation with the aortic size index (ASI). Methods: Forty-eight patients with thoracic aortic aneurysm were enrolled in this study. A standard magnetic resonance imaging (MRI) protocol was used to calculate MRSD and MRDR. Both MRSD and MRDR were expressed as percentile of maximal area/10-3 sec. ASI (maximal aortic diameter/body surface area) was calculated. A correlation between MRSD, MRDR, ASI, and the patient’s age was performed using regression plot. Results: A significant correlation between MRSD (t=-4,36; r2=0.29; P≤0.0001), MRDR (t=3.92; r2=0.25; P=0.0003), and ASI (25±4.33 mm/m2; range 15,48-35,14 mm/m2) is observed. As ASI increases, aortic MRSD and MRDR decrease. Such inverse correlation between MRSD, MRDR, and ASI indicates increased stiffness of the ascending aorta. A significant correlation between the patient’s age and the decrease in MRSD and MRDR is observed. Conclusion: MRSD and MRDR are significantly correlated with ASI and the patient’s age. They seem to describe properly the increasing stiffness of aortas. These two new indexes provide a promising, accessible, and reproducible approach to evaluate the biomechanical property of the aorta.
DOI: 10.6084/m9.figshare.9739370.v1
title: Prevalence of anxiety and associated factors in adults

description: ABSTRACT Objective Identify the prevalence of anxiety disorders in a population sample and associated factors. Methods A cross-sectional study of population base conducted with individuals between 18 and 35 years old. Sociodemographic variables, body mass index (BMI), presence of diseases, and use of alcohol and smoke were analyzed. The anxiety disorders were verified by the clinical interview Mini International Neuropsychiatric Interview 5.0. For the analysis, was used the Chi-square test, considering a confidence interval of 95%. Results The prevalence of general anxiety was 27.4%. Agoraphobia (17.9%) and generalized anxiety disorder (14.3%) were the most prevalent. Women presented a higher prevalence of general anxiety with 32.5% when compared with man (21,3%) (p &lt; 0.001). The variables gender, years of study, income, health problems, smoking, and alcohol were associated to more than three anxiety disorders investigated (p &lt; 0,001). Conclusions The findings demonstrate that anxiety disorders are frequent in adults, being more prevalent among women. It was associated mainly with socioeconomic conditions and legal substances. Knowing the prevalence of anxiety disorders and associated factors can help health professionals to develop better diagnoses and treatments.
DOI: 10.6084/m9.figshare.9739355
title: The Effect of Continuous Ventilation on Thiol-Disulphide Homeostasis and Albumin-Adjusted Ischemia-Modified Albumin During Cardiopulmonary Bypass

description: Abstract Objective: To investigate the effect of continuous lung ventilation with low tidal volume on oxidation parameters, such as thiol/disulphide homeostasis and albumin-adjusted ischemia-modified albumin (AAIMA), during cardiopulmonary bypass (CBP) in coronary artery bypass grafting (CABG). Methods: Seventy-four patients who underwent elective CABG with CPB were included in the study. Blood samples were taken in the preoperative period, 10 minutes after CPB, and six and 24 hours postoperatively. Patients were assigned to the continuous ventilation group (Group 1, n=37) and the non-ventilated group (Group 2, n=37). The clinical characteristics, thiol/disulphide homeostasis, ischemia-modified albumin (IMA), and AAIMA levels of the patients were compared. Results: A significant difference was found between the groups regarding native thiol, total thiol, and IMA levels at the postoperative 24th hour (P=0.030, P=0.031, and P=0.004, respectively). There was no difference between the groups in terms of AAIMA. AAIMA levels returned to preoperative levels in Groups 1 and 2, at the 6th and 24th postoperative hours, respectively. Length of hospital stay was significantly shorter in Group 1 (P&lt;0.001) than in Group 2. Conclusion: Continuous ventilation during CPB caused an increase in native and total thiol levels, an earlier return of AAIMA levels, and shorter hospital stay. Continuous ventilation may reduce the negative effects of CPB on myocardium (Table 2, Figure 1, and Reference 31).
DOI: 10.6084/m9.figshare.9739361.v1
title: Why Use the Radial Artery? The Saphenous Vein is the Second Graft of Choice for CABG in Brazil

description: Abstract The saphenous vein (SV) is the most commonly used conduit for coronary artery bypass surgery (CABG) and the second conduit of choice in Brazil and many other countries. The radial artery (RA) is suggested, by some, to be superior to SV grafts, although its use in the USA declined over a 10 year period. The patency of SV grafts (SVG) is improved when the vein is harvested with minimal trauma using the no-touch (NT) technique. This improved performance is due to the preservation of the outer pedicle surrounding the SV and reduction in vascular damage that occurs when using conventional techniques (CT) of harvesting. While the patency of NT SVGs has been shown superior to the RA at 36 months in one study, data from the RADIAL trial suggests the RA to be the superior conduit. When additional data using NT SVG is included in this trial the difference in risk of graft occlusion between the RA and SV grafts dissipates with there no longer being a significant difference in patency between conduits. The importance of preserving SV structure and the impact of NT harvesting on conduit choice for CABG patients are discussed in this short review.
DOI: 10.6084/m9.figshare.9739355.v1
title: The Effect of Continuous Ventilation on Thiol-Disulphide Homeostasis and Albumin-Adjusted Ischemia-Modified Albumin During Cardiopulmonary Bypass

description: Abstract Objective: To investigate the effect of continuous lung ventilation with low tidal volume on oxidation parameters, such as thiol/disulphide homeostasis and albumin-adjusted ischemia-modified albumin (AAIMA), during cardiopulmonary bypass (CBP) in coronary artery bypass grafting (CABG). Methods: Seventy-four patients who underwent elective CABG with CPB were included in the study. Blood samples were taken in the preoperative period, 10 minutes after CPB, and six and 24 hours postoperatively. Patients were assigned to the continuous ventilation group (Group 1, n=37) and the non-ventilated group (Group 2, n=37). The clinical characteristics, thiol/disulphide homeostasis, ischemia-modified albumin (IMA), and AAIMA levels of the patients were compared. Results: A significant difference was found between the groups regarding native thiol, total thiol, and IMA levels at the postoperative 24th hour (P=0.030, P=0.031, and P=0.004, respectively). There was no difference between the groups in terms of AAIMA. AAIMA levels returned to preoperative levels in Groups 1 and 2, at the 6th and 24th postoperative hours, respectively. Length of hospital stay was significantly shorter in Group 1 (P&lt;0.001) than in Group 2. Conclusion: Continuous ventilation during CPB caused an increase in native and total thiol levels, an earlier return of AAIMA levels, and shorter hospital stay. Continuous ventilation may reduce the negative effects of CPB on myocardium (Table 2, Figure 1, and Reference 31).
DOI: 10.6084/m9.figshare.9739346
title: Modeling and simulation of Talaromyces flavus growth in pineapple: an integration between kinetic and transport phenomena models

description: Abstract The study of the dynamic behavior of microbial growth in foods is extremely important to extend the shelf life of foodstuff. In this work, a kinetic model describing the growth of Talaromyces flavus in pineapple was integrated with a thermal model. The integrated model was used in order to simulate the product’s shelf life in heating scenarios. Kinetic experiments were performed in 4 distinct temperatures (from 20 °C to 35 °C), and statistical indices were used to select the best primary and secondary models. The thermal model was developed based on the analytical solution of the heat diffusion equation for flat plates and infinite cylinders. It was shown that the modified Gompertz model (BF=1.003, AF=1.049, RSS=3.687 and RMSE=1.286), along with the extended square root model (BF=0.999, AF=1.012 and RSS=0.2684) and the second order polynomial model (BF=0.991, AF=1.011, RSS=0.006 and RMSE=0.078) were the most satisfactory models. The kinetic model was validated in both static and dynamic temperature conditions (in two distinct scenarios) to assure that it could be integrated with the heat transfer equations. Simulations had shown a 23.3% increase in shelf life increasing the product’s length (from 2 to 30 cm) and an 88.2% increase with the diminution of the ambient air temperature (from 34 °C to 22 °C). Less pronounced effects were obtained varying the product’s diameter and the velocity of the ambient air.
DOI: 10.6084/m9.figshare.9739358.v1
title: A Dedicated Stitch to Allow Early Safe Mobilization Avoiding Drain-Induced Heart Injury

description: Abstract Placement of a mediastinal drain is a routine procedure following heart surgery. Postoperative bed rest is often imposed due to the fear of potential risk of drain displacement and cardiac injury. We developed an encapsulating stitch as a feasible, effective and low-cost technique, which does not require advanced surgical skills for placement. This simple, novel approach compartmentalizes the drain allowing for safe early mobilization following cardiac surgery.
DOI: 10.6084/m9.figshare.9739340
title: Tax morals and the Brazilian citizen: an empirical study

description: Abstract This study analyzes the tax morals of the Brazilian citizen, aiming to measure its level, as well as if there is a difference of the tax morals in the sociodemographic characteristics. Tax morale is an important determinant of compliance with tax legislation, so measuring it and evaluate each aspect that determines it allows to strategize and ensure better fiscal conformity. The research period was between May and August 2017, with 679 participants. The questionnaire adapted from the work of Torgler, Schaffner, and MacIntyre (2007), with multiple choice objective questions allowed the collection of data from individuals and was applied indirectly, electronically, validated by the use of the Cronbach’s alpha. The results showed in medium terms a neutral or partially contrary perception of the practice of tax evasion. As far as gender is concerned, the results indicate that women generally have higher tax morals than men. Regarding religion it has been demonstrated that spiritualists have higher tax morals compared to participants from other religions. As for education, the higher the formal education, the higher the tax moral. The results are relevant and meaningful, and help to better understand the challenge of tax compliance, as well as offer elements to insire future research on the subject, considering its theoretical and social relevance, and the fact that it is little studied in Brazil.
DOI: 10.6084/m9.figshare.9739346.v1
title: Modeling and simulation of Talaromyces flavus growth in pineapple: an integration between kinetic and transport phenomena models

description: Abstract The study of the dynamic behavior of microbial growth in foods is extremely important to extend the shelf life of foodstuff. In this work, a kinetic model describing the growth of Talaromyces flavus in pineapple was integrated with a thermal model. The integrated model was used in order to simulate the product’s shelf life in heating scenarios. Kinetic experiments were performed in 4 distinct temperatures (from 20 °C to 35 °C), and statistical indices were used to select the best primary and secondary models. The thermal model was developed based on the analytical solution of the heat diffusion equation for flat plates and infinite cylinders. It was shown that the modified Gompertz model (BF=1.003, AF=1.049, RSS=3.687 and RMSE=1.286), along with the extended square root model (BF=0.999, AF=1.012 and RSS=0.2684) and the second order polynomial model (BF=0.991, AF=1.011, RSS=0.006 and RMSE=0.078) were the most satisfactory models. The kinetic model was validated in both static and dynamic temperature conditions (in two distinct scenarios) to assure that it could be integrated with the heat transfer equations. Simulations had shown a 23.3% increase in shelf life increasing the product’s length (from 2 to 30 cm) and an 88.2% increase with the diminution of the ambient air temperature (from 34 °C to 22 °C). Less pronounced effects were obtained varying the product’s diameter and the velocity of the ambient air.