cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.7185695
title: Pegylated interferon for treating severe recurrent respiratory papillomatosis in a child: case report

description: ABSTRACT CONTEXT: Recurrent respiratory papillomatosis (RRP) is the most common laryngeal tumor. During childhood, it may present in extremely severe forms defined by the need for frequent surgical procedures to relieve respiratory distress and/or involvement of extralaryngeal sites such as lung involvement. Adjuvant therapies are indicated in these cases and interferon is one of the options. Pegylated interferon is more effective than conventional alpha interferon and, given its reported results in relation to treating hepatitis C over the past decade, we hypothesized that this might be more effective than conventional interferon also for treating respiratory papillomatosis. Use of a treatment strategy that eliminates the need for general anesthesia is particularly appealing, yet obtaining approval for use of medications that are not currently used for this purpose is challenging. CASE REPORT: We report the case of a child with severe RRP that had been followed for the preceding six years, who was treated with pegylated interferon after failure of other adjuvant therapies. There was noticeable improvement in the frequency of surgical procedures, which was regarded very receptively, considering the child’s history and previous response to other therapies. CONCLUSION: Pegylated interferon may be a good option for diminishing the need for surgical intervention in severe cases of recurrent respiratory papillomatosis.
DOI: 10.6084/m9.figshare.7185695.v1
title: Pegylated interferon for treating severe recurrent respiratory papillomatosis in a child: case report

description: ABSTRACT CONTEXT: Recurrent respiratory papillomatosis (RRP) is the most common laryngeal tumor. During childhood, it may present in extremely severe forms defined by the need for frequent surgical procedures to relieve respiratory distress and/or involvement of extralaryngeal sites such as lung involvement. Adjuvant therapies are indicated in these cases and interferon is one of the options. Pegylated interferon is more effective than conventional alpha interferon and, given its reported results in relation to treating hepatitis C over the past decade, we hypothesized that this might be more effective than conventional interferon also for treating respiratory papillomatosis. Use of a treatment strategy that eliminates the need for general anesthesia is particularly appealing, yet obtaining approval for use of medications that are not currently used for this purpose is challenging. CASE REPORT: We report the case of a child with severe RRP that had been followed for the preceding six years, who was treated with pegylated interferon after failure of other adjuvant therapies. There was noticeable improvement in the frequency of surgical procedures, which was regarded very receptively, considering the child’s history and previous response to other therapies. CONCLUSION: Pegylated interferon may be a good option for diminishing the need for surgical intervention in severe cases of recurrent respiratory papillomatosis.
DOI: 10.7284/121084
title: Anemometer data collected during research cruise TN321 using a RM Young 06206 instrument system onboard the platform RV Thomas G. Thompson

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7185689
title: Mutations in the melanocortin-1 receptor (MC1R) gene have no influence on the distinct patterns of melanic plumage found in the manakins of the genus Antilophia (Aves: Pipridae)

description: Abstract The melanocortin-1 receptor gene is the most widely-used marker for the investigation of the genetic determination of melanic plumage patterns. Studies of a number of wild bird species have shown an association between non-synonymous mutations of the MC1R gene and the presence of melanic variants. The genus Antilophia (Pipridae) includes only two manakin species (A. galeata and A. bokermanni), which are distinguished primarily by the differences in the pattern of melanic coloration of the plumage of the mantle in the adult males. In A. galeata, this plumage is black, while in A. bokermanni, it is predominantly white. This study investigates the possible association between mutations of the MC1R marker and the variation in plumage coloration observed in the two species. The MC1R sequences of the two species was analyzed, and the observed nucleotide variation was compared. Six polymorphic sites were identified, representing seven distinct genotypes. Five of these polymorphic mutations were non-synonymous, but were not related to the different phenotypes. Neutral evolution and the absence of any systematic association between the variants of the MC1R and plumage coloration in the Antilophia species indicate that alternative mechanisms regulate the expression of the coloration of the plumage in the adult males.
DOI: 10.6084/m9.figshare.7185689.v1
title: Mutations in the melanocortin-1 receptor (MC1R) gene have no influence on the distinct patterns of melanic plumage found in the manakins of the genus Antilophia (Aves: Pipridae)

description: Abstract The melanocortin-1 receptor gene is the most widely-used marker for the investigation of the genetic determination of melanic plumage patterns. Studies of a number of wild bird species have shown an association between non-synonymous mutations of the MC1R gene and the presence of melanic variants. The genus Antilophia (Pipridae) includes only two manakin species (A. galeata and A. bokermanni), which are distinguished primarily by the differences in the pattern of melanic coloration of the plumage of the mantle in the adult males. In A. galeata, this plumage is black, while in A. bokermanni, it is predominantly white. This study investigates the possible association between mutations of the MC1R marker and the variation in plumage coloration observed in the two species. The MC1R sequences of the two species was analyzed, and the observed nucleotide variation was compared. Six polymorphic sites were identified, representing seven distinct genotypes. Five of these polymorphic mutations were non-synonymous, but were not related to the different phenotypes. Neutral evolution and the absence of any systematic association between the variants of the MC1R and plumage coloration in the Antilophia species indicate that alternative mechanisms regulate the expression of the coloration of the plumage in the adult males.
DOI: 10.7284/119100
title: Expendable Probe data collected during research cruise TN321 using a Sippican MK21 instrument system onboard the platform RV Thomas G. Thompson

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/119104
title: GNSS (Global Navigation Satellite System) data collected during research cruise TN321 using a C&C C-Nav 3050 instrument system onboard the platform RV Thomas G. Thompson

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7185674
title: TRACE ELEMENTS IN RIVER WATERS AND SEDIMENTS BEFORE AND AFTER A MINING DAM BREACH (BENTO RODRIGUES, BRAZIL)

description: On November 5, 2015, the Fundão dam ruptured which caused the spill of a large quantity of tailings from the extraction of iron ores to the Gualaxo do Norte, Carmo and Doce Rivers. Seven months prior to the rupture, our group had collected water and sediment samples at 13 points along the Tripuí Creek and the entire length of the Carmo River. Six months after deposition of the mud, new samples were collected in the Carmo River. Thus, the present study sought to evaluate the concentrations of trace elements in the waters and their distribution and mobility in sediment by BCR sequential extraction before and after the deposition of the tailings mud. Arsenic concentrations in the water samples were between 10.4 and 50.4 µg L-1, which exceeded 10 ug L-1 (maximum limit permitted by Brazilian environmental regulations for water destined for human consumption) . The tailing mud layer on the sediments caused concentration increases of As (20%), Cd (13%), Co (5%), Cr (9%), Cu (11%), Ni (4%), Pb (7%) and Zn (19%) in the easily remobilized fractions. The presence of the elements in these fractions was indicative of high ecotoxicological risk and potential harm to the health of the local population.
DOI: 10.6084/m9.figshare.7185674.v1
title: TRACE ELEMENTS IN RIVER WATERS AND SEDIMENTS BEFORE AND AFTER A MINING DAM BREACH (BENTO RODRIGUES, BRAZIL)

description: On November 5, 2015, the Fundão dam ruptured which caused the spill of a large quantity of tailings from the extraction of iron ores to the Gualaxo do Norte, Carmo and Doce Rivers. Seven months prior to the rupture, our group had collected water and sediment samples at 13 points along the Tripuí Creek and the entire length of the Carmo River. Six months after deposition of the mud, new samples were collected in the Carmo River. Thus, the present study sought to evaluate the concentrations of trace elements in the waters and their distribution and mobility in sediment by BCR sequential extraction before and after the deposition of the tailings mud. Arsenic concentrations in the water samples were between 10.4 and 50.4 µg L-1, which exceeded 10 ug L-1 (maximum limit permitted by Brazilian environmental regulations for water destined for human consumption) . The tailing mud layer on the sediments caused concentration increases of As (20%), Cd (13%), Co (5%), Cr (9%), Cu (11%), Ni (4%), Pb (7%) and Zn (19%) in the easily remobilized fractions. The presence of the elements in these fractions was indicative of high ecotoxicological risk and potential harm to the health of the local population.
DOI: 10.7284/121253
title: GNSS (Global Navigation Satellite System) data collected during research cruise TN321 using a C&C C-Nav 2000 instrument system onboard the platform RV Thomas G. Thompson

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7185668
title: Determination of 4-Nonylphenol in Surface Waters of the Guandu River Basin by High Performance Liquid Chromatography with Ultraviolet Detection

description: 4-Nonylphenol, a degradation product of ethoxylated alkylphenols, due to its harmful effects on the environment, has been banned in European Union countries, alongside their precursors. The guide on quality of drinking water from the United States Environmental Protection Agency (US EPA) recommends a maximum concentration of 28 µg L-1 for fresh water. In Brazil, there is no clear legislation containing values of maximum concentration of 4-nonylphenol. Due to this lack of regulation, a continuous monitoring is necessary for this pollutant in environmental samples. The occurrence of 4-nonylphenol (4-NP) in the surface waters of Guandu River in the state of Rio de Janeiro, Brazil, was studied by using solid-phase extraction and reversed phase liquid chromatography separation with UV detection. The analytical method satisfies these requirements, being able to detect and quantify 4-NP in a desired concentration range. Of the 19 samples analyzed, 4-nonylphenol was detected in 12, quantified in 2, showing concentration levels of 1.73 and 2.32 µg L-1 in Santa Cruz and Paracambi, respectively. This is the main hydrographic basin in the state of Rio de Janeiro, where water is collected for treatment and later distributed to most cities in the metropolitan region, including Rio de Janeiro City, and these results are therefore alarming.
DOI: 10.6084/m9.figshare.7185662
title: Effect of 0.15% sodium hialuronate and 0.5% carboxymethylcellulose on tear film breakup time in healthy dogs and in dogs with keratoconjunctivitis sicca

description: ABSTRACT This study aimed to evaluate the effect of the 0.15% sodium hyaluronate (SH) and of 0.5% carboxymethylcellulose (CMC) on tear film breakup time (TFBUT) in 10 healthy dogs and in 32 eyes of dogs with keratoconjunctivis sicca (KCS). In addition, the goblet cell density (GCD) of this population was quantified. TFBUT was assessed at baseline and at different time points following the instillation of SH and CMC. KCS was graded as mild, moderate, and severe. GCD were quantified from conjunctival biopsies. The number of GCD differed significantly between patients with mild and moderate KCS (P&lt;0.01). TFBUT of healthy dogs increased only for 1 minute after treatment with SH (P&lt;0.01). Regarding baseline and treatments, SH significantly increased TFBUT for up to 30 minutes on the ocular surface, in comparison to CMC, in all categories of KCS (P&lt;0.01). TFBUT and GCD correlated positively when the healthy and diseased eyes were grouped (r=0.41, P=0.006). It can be concluded that in dogs with KCS, SH lasts longer periods on the ocular surface than CMC, but such agents does not increase TFBUT in healthy dogs. Additionally, tear film stability tends to reduce in a linear fashion from the mild to severe form of KCS.
DOI: 10.6084/m9.figshare.7185665
title: Influence of epidural morphine or tramadol in gastrointestinal transit of horses

description: ABSTRACT Opioids provide analgesia and are used in veterinary, however there is a restriction regarding the use of these drugs in horses, because may lead to ileus, but epidural opioids minimize those side effects. Eight healthy horses were used in three experimental groups, to evaluate the gastrointestinal influence after epidural morphine (0.2mg / kg), tramadol (1.0mg / kg) or NaCl 0.9%. Intestinal transit was evaluated with the administration of Lipe® (purified enriched isolated lignin) and later analyzed in the feces. Feces were collected before the epidural and at intervals up to 48 hours after the beginning of the experiment. The data were analyzed by a one-way analysis of variance or Friedman or Kruskal-Wallis and Student-Newman Keuls test as a post hoc. A value of P≤ 0.05 was considered significant. Epidural morphine or tramadol did not change the mean time for retention of the liquid phase, passage rate, and the transit time of the marker used. In conclusion, epidural morphine or tramadol does not change gastrointestinal transit.
DOI: 10.7284/119102
title: Gravimeter data collected during research cruise TN321 using a Bell BGM-3 instrument system onboard the platform RV Thomas G. Thompson

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7185665.v1
title: Influence of epidural morphine or tramadol in gastrointestinal transit of horses

description: ABSTRACT Opioids provide analgesia and are used in veterinary, however there is a restriction regarding the use of these drugs in horses, because may lead to ileus, but epidural opioids minimize those side effects. Eight healthy horses were used in three experimental groups, to evaluate the gastrointestinal influence after epidural morphine (0.2mg / kg), tramadol (1.0mg / kg) or NaCl 0.9%. Intestinal transit was evaluated with the administration of Lipe® (purified enriched isolated lignin) and later analyzed in the feces. Feces were collected before the epidural and at intervals up to 48 hours after the beginning of the experiment. The data were analyzed by a one-way analysis of variance or Friedman or Kruskal-Wallis and Student-Newman Keuls test as a post hoc. A value of P≤ 0.05 was considered significant. Epidural morphine or tramadol did not change the mean time for retention of the liquid phase, passage rate, and the transit time of the marker used. In conclusion, epidural morphine or tramadol does not change gastrointestinal transit.
DOI: 10.6084/m9.figshare.7185662.v1
title: Effect of 0.15% sodium hialuronate and 0.5% carboxymethylcellulose on tear film breakup time in healthy dogs and in dogs with keratoconjunctivitis sicca

description: ABSTRACT This study aimed to evaluate the effect of the 0.15% sodium hyaluronate (SH) and of 0.5% carboxymethylcellulose (CMC) on tear film breakup time (TFBUT) in 10 healthy dogs and in 32 eyes of dogs with keratoconjunctivis sicca (KCS). In addition, the goblet cell density (GCD) of this population was quantified. TFBUT was assessed at baseline and at different time points following the instillation of SH and CMC. KCS was graded as mild, moderate, and severe. GCD were quantified from conjunctival biopsies. The number of GCD differed significantly between patients with mild and moderate KCS (P&lt;0.01). TFBUT of healthy dogs increased only for 1 minute after treatment with SH (P&lt;0.01). Regarding baseline and treatments, SH significantly increased TFBUT for up to 30 minutes on the ocular surface, in comparison to CMC, in all categories of KCS (P&lt;0.01). TFBUT and GCD correlated positively when the healthy and diseased eyes were grouped (r=0.41, P=0.006). It can be concluded that in dogs with KCS, SH lasts longer periods on the ocular surface than CMC, but such agents does not increase TFBUT in healthy dogs. Additionally, tear film stability tends to reduce in a linear fashion from the mild to severe form of KCS.
DOI: 10.7284/121254
title: Gyrocompass data collected during research cruise TN321 using a Sperry MK-37 instrument system onboard the platform RV Thomas G. Thompson

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7185650
title: DEVELOPMENT AND OPTIMIZATION OF A SINGLE-STEP CATION CHROMATOGRAPHIC WHEY PROTEIN FRACTIONATION PROCESS: EVALUATION AND COMPARISON OF SCALE-UP STRATEGIES

description: Abstract This manuscript presents evaluation of various strategies used for the scale-up of chromatographic purification systems. Towards that end, the manuscript provides development and optimization of a single-step whey protein concentrate (WPC) fractionation process at lab scale on a 1.0 × 19 cm column using UNOsphere S. Subsequently, scale-up of this newly developed process and conduction of trials at higher scale is also undertaken by applying various scale-up strategies. For these trials, this work categorized various scale-up factors into constant velocity (CV) and constant bed volume per hour (CBVH) scale-up methods. Scale-up trials in bigger diameter (1.5 cm and 2.5 cm) columns with height to diameter ratio (H/D) =19 and &lt;19 were performed. The effects of changing flow velocity and H/D ratio due to the applied scale-up strategy were evaluated and compared with lab performance in terms of resolution vs. height equivalent to theoretical plate (HETP) relationship. The CBVH method was found to be an efficient method for the scale-up of the developed whey protein resolution system. Also an equation for the prediction of resolution in a scaled column on the basis of a HETP-resolution correlation is presented. It is useful for the prediction of either resolution or bed height in scaled column of WPC or similar biomolecular purification systems.
DOI: 10.7284/121083
title: Meteorological Station data collected during research cruise TN321 using a RM Young 26800 instrument system onboard the platform RV Thomas G. Thompson

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7185641
title: Biotic potential and reproductive parameters of Spodoptera cosmioides (Walker) (Lepidoptera: Noctuidae) in the laboratory

description: Abstract In this study we evaluate the biotic potential and reproductive parameters of Spodoptera cosmioides (Walker, 1858) under controlled conditions (25 ± 1 °C, 70 ± 10% RH and 14 hour photophase). Females, on average, (14.433 days) did not live significantly longer than their male counterparts (13.100 days). The mean durations of the pre-oviposition, oviposition and post-oviposition periods were 2.767, 10.600 and 1.067 days, respectively. The mean fecundity of females was 5,073.533 eggs and the mean fertility was 5,021.027 larvae. On average, females copulated 1.167 times. Fecundity was positively correlated with the number of copulations (r = 0.583, P &lt;0.001). The number of copulations, however, was negatively correlated whit the duration of the pre-oviposition (r = -0.560, P = 0.007) and oviposition (r = -0.479, P = 0.048) periods, and overall longevity (r = -0.512, P = 0.031). The biotic potential was estimated at 6.547 x 1021 individuals/female/year. The net reproductive rate (Ro) was 2,193.722 times per generation and the mean generation time (T) was 46.407 days. The intrinsic rate of increase (rm) was 0.166, with a finite rate of increase (λ) of 1.180, per week.
DOI: 10.6084/m9.figshare.7185644
title: Use of eugenol for anesthesia of lesser guitarfish Zapteryx brevirostris (Rhinobatidae)

description: Abstract Anesthesia can be utilized as a non-lethal procedure to allow easy handling of teleosts and elasmobranchs in captivity or in the wild. For this, anesthetic protocols need to be established according to the species. The aim of this study was to determine the ideal concentration of eugenol for anesthesia of Zapteryx brevirostris. Four concentrations were tested: 21.25, 42.50, 85.00 and 170.00 mg L-1 (ratio of 1:5 with absolute ethanol). The perfect concentration of eugenol for this species was 85.0 mg L-1 , which enabled up to 300 seconds of work on the fish, without any response to handling.
DOI: 10.6084/m9.figshare.7185650.v1
title: DEVELOPMENT AND OPTIMIZATION OF A SINGLE-STEP CATION CHROMATOGRAPHIC WHEY PROTEIN FRACTIONATION PROCESS: EVALUATION AND COMPARISON OF SCALE-UP STRATEGIES

description: Abstract This manuscript presents evaluation of various strategies used for the scale-up of chromatographic purification systems. Towards that end, the manuscript provides development and optimization of a single-step whey protein concentrate (WPC) fractionation process at lab scale on a 1.0 × 19 cm column using UNOsphere S. Subsequently, scale-up of this newly developed process and conduction of trials at higher scale is also undertaken by applying various scale-up strategies. For these trials, this work categorized various scale-up factors into constant velocity (CV) and constant bed volume per hour (CBVH) scale-up methods. Scale-up trials in bigger diameter (1.5 cm and 2.5 cm) columns with height to diameter ratio (H/D) =19 and &lt;19 were performed. The effects of changing flow velocity and H/D ratio due to the applied scale-up strategy were evaluated and compared with lab performance in terms of resolution vs. height equivalent to theoretical plate (HETP) relationship. The CBVH method was found to be an efficient method for the scale-up of the developed whey protein resolution system. Also an equation for the prediction of resolution in a scaled column on the basis of a HETP-resolution correlation is presented. It is useful for the prediction of either resolution or bed height in scaled column of WPC or similar biomolecular purification systems.
DOI: 10.6084/m9.figshare.7185641.v1
title: Biotic potential and reproductive parameters of Spodoptera cosmioides (Walker) (Lepidoptera: Noctuidae) in the laboratory

description: Abstract In this study we evaluate the biotic potential and reproductive parameters of Spodoptera cosmioides (Walker, 1858) under controlled conditions (25 ± 1 °C, 70 ± 10% RH and 14 hour photophase). Females, on average, (14.433 days) did not live significantly longer than their male counterparts (13.100 days). The mean durations of the pre-oviposition, oviposition and post-oviposition periods were 2.767, 10.600 and 1.067 days, respectively. The mean fecundity of females was 5,073.533 eggs and the mean fertility was 5,021.027 larvae. On average, females copulated 1.167 times. Fecundity was positively correlated with the number of copulations (r = 0.583, P &lt;0.001). The number of copulations, however, was negatively correlated whit the duration of the pre-oviposition (r = -0.560, P = 0.007) and oviposition (r = -0.479, P = 0.048) periods, and overall longevity (r = -0.512, P = 0.031). The biotic potential was estimated at 6.547 x 1021 individuals/female/year. The net reproductive rate (Ro) was 2,193.722 times per generation and the mean generation time (T) was 46.407 days. The intrinsic rate of increase (rm) was 0.166, with a finite rate of increase (λ) of 1.180, per week.