cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.8668190
title: Table S1. Finningley MCR comparisons from Mid-Devensian climate and landscape in England: new data from Finningley, South Yorkshire

description: Mutual Climatic Range (MCR) calculation results for MIS 3 beetle based climate reconstrutions shown in figure 16. Data include comparison with modern day termperatures for Finningley.
DOI: 10.6084/m9.figshare.8668193
title: Table S2. Dating evidence from Mid-Devensian climate and landscape in England: new data from Finningley, South Yorkshire

description: Dating evidence for MIS 3 sites cited in the text
DOI: 10.6084/m9.figshare.8668190.v1
title: Table S1. Finningley MCR comparisons from Mid-Devensian climate and landscape in England: new data from Finningley, South Yorkshire

description: Mutual Climatic Range (MCR) calculation results for MIS 3 beetle based climate reconstrutions shown in figure 16. Data include comparison with modern day termperatures for Finningley.
DOI: 10.6084/m9.figshare.8668193.v1
title: Table S2. Dating evidence from Mid-Devensian climate and landscape in England: new data from Finningley, South Yorkshire

description: Dating evidence for MIS 3 sites cited in the text
DOI: 10.6084/m9.figshare.8668124
title: Supplementary Material for: Effects of Iliac Stenosis on Abdominal Aortic Aneurysm Formation in Mice and Humans

description: Reduced lower-limb blood flow has been shown to lead to asymmetrical abdominal aortic aneurysms (AAAs) but the mechanism of action is not fully understood. Therefore, small animal ultrasound (Vevo2100, FUJIFILM VisualSonics) was used to longitudinally study mice that underwent standard porcine pancreatic elastase (PPE) infusion (<i>n</i> = 5), and PPE infusion with modified 20% iliac artery stenosis in the left (<i>n</i> = 4) and right (<i>n</i> = 5) iliac arteries. Human AAA computed tomography images were obtained from patients with normal (<i>n</i> = 9) or stenosed left (<i>n</i> = 2), right (<i>n</i> = 1), and bilateral (<i>n</i> = 1) iliac arteries. We observed rapid early growth and rightward expansion (8/9 mice) in the modified PPE groups (<i>p</i> &lt; 0.05), leading to slightly larger and asymmetric AAAs compared to the standard PPE group. Further examination showed a significant increase in TGFβ1 (<i>p</i> &lt; 0.05) and cellular infiltration (<i>p</i> &lt; 0.05) in the modified PPE group versus standard PPE mice. Congruent, yet variable, observations were made in human AAA patients with reduced iliac outflow compared to those with normal iliac outflow. Our results suggest that arterial stenosis at the time of aneurysm induction leads to faster AAA growth with aneurysm asymmetry and increased vascular inflammation after 8 weeks, indicating that moderate iliac stenosis may have upstream effects on AAA progression.
DOI: 10.6084/m9.figshare.8668124.v1
title: Supplementary Material for: Effects of Iliac Stenosis on Abdominal Aortic Aneurysm Formation in Mice and Humans

description: Reduced lower-limb blood flow has been shown to lead to asymmetrical abdominal aortic aneurysms (AAAs) but the mechanism of action is not fully understood. Therefore, small animal ultrasound (Vevo2100, FUJIFILM VisualSonics) was used to longitudinally study mice that underwent standard porcine pancreatic elastase (PPE) infusion (<i>n</i> = 5), and PPE infusion with modified 20% iliac artery stenosis in the left (<i>n</i> = 4) and right (<i>n</i> = 5) iliac arteries. Human AAA computed tomography images were obtained from patients with normal (<i>n</i> = 9) or stenosed left (<i>n</i> = 2), right (<i>n</i> = 1), and bilateral (<i>n</i> = 1) iliac arteries. We observed rapid early growth and rightward expansion (8/9 mice) in the modified PPE groups (<i>p</i> &lt; 0.05), leading to slightly larger and asymmetric AAAs compared to the standard PPE group. Further examination showed a significant increase in TGFβ1 (<i>p</i> &lt; 0.05) and cellular infiltration (<i>p</i> &lt; 0.05) in the modified PPE group versus standard PPE mice. Congruent, yet variable, observations were made in human AAA patients with reduced iliac outflow compared to those with normal iliac outflow. Our results suggest that arterial stenosis at the time of aneurysm induction leads to faster AAA growth with aneurysm asymmetry and increased vascular inflammation after 8 weeks, indicating that moderate iliac stenosis may have upstream effects on AAA progression.
DOI: 10.6084/m9.figshare.8667815
title: RAD-Seq of yellow perch for diversity assessment

description: We applied restriction site-associated DNA sequencing (RAD-Seq) to yellow perch geographic demes to develop large numbers of polymorphic genetic markers, including single nucleotide polymorphisms and simple sequence repeats, and to evaluate nucleotide diversity. A total of 258,056 contigs were assembled with the length of 605 ± 71 (mean ± SD) bp, which were longer than those just using HiSeq data. Nucleotide diversity (π) was 0.00304 with 95% confidence intervals from 0.00303 to 0.00304. Based on the assembled sequences, a total of 59,766 perfect single sequence repeats were detected, with AC/GT being the most common repeat motif and GC being the rarest. Based on this breeding population, 41,736 high-quality single nucleotide polymorphisms and 10,412 polymorphic single sequence repeats were obtained. Validation of amplification by randomly selecting 40 polymorphic single sequence repeats showed a high success rate (85%).
DOI: 10.6084/m9.figshare.8667821
title: Trophic state index validation based on the phytoplankton functional group approach in Amazon floodplain lakes

description: Many trophic indices have been constructed for temperate aquatic environments, but few have proved reliable for tropical environments. Indices constructed on the basis of nutrients may not be effective for describing the trophic state because the fractions of nitrogen and phosphorus differ in their potential to predict the nutrient limitation in tropical aquatic environments. We developed an index based on the phytoplankton Reynolds functional groups for an Amazonian floodplain lake from samples collected during 2 contrasting hydrological periods (rising and flushing) and compared it with the index initially proposed by Carlson in 1977 and further adapted to tropical environments by Toledo in 1990. The functional group and Carlson indices matched only 37% and 56% of the sample units collected during the rising and flushing periods, respectively. Our study confirms the difficulty of assessing trophic states using only phosphorus and chlorophyll <i>a</i> in tropical floodplain lakes. In this environment (1) nitrogen may significantly limit phytoplankton growth and (2) complex phytoplankton–nutrient relationships occur during the hydrological cycle that cannot be accounted for through a simple phosphorus and chlorophyll <i>a</i> formula.
DOI: 10.6084/m9.figshare.8667809
title: Eutrophication and browning influence <i>Daphnia</i> nutritional ecology

description: Climate change and land-use practices can enhance lake eutrophication and browning, which influence phytoplankton composition by decreasing the availability of food high in nutritional quality (algae) and increasing the abundance of low-quality food (terrestrial detritus, bacteria) for herbivorous zooplankton. Nutritionally valuable algae for zooplankton are rich in essential biomolecules such as amino acids, polyunsaturated fatty acids (PUFAs), sterols, and phosphorus. We performed laboratory experiments and showed a stronger positive relationship between zooplankton (<i>Daphnia</i>) cumulative offspring number and availability of high-quality algae (Cryptophytes: <i>Rhodomonas/Cryptomonas</i>; and Chrysophytes: <i>Mallomonas</i>) than with intermediate-quality (Chlorophytes: <i>Acutodesmus</i>) or poor-quality (Dinoflagellates: <i>Peridinium</i>) algae. The higher cumulative offspring number of <i>Daphnia</i> was a result of higher amounts of total ω-3 and ω-6 PUFA, proteins, sterols, and amino acids in the algal diets. The experiments also showed that even a small addition of high-quality algae (<i>Rhodomonas</i>) to intermediate-quality (<i>Acutodesmus</i>) or low-quality (bacteria, heterotrophic nanoflagellates, or terrestrial organic matter) diets can enhance the <i>Daphnia</i> cumulative offspring production. Our carbon mass balance calculation for a eutrophic clearwater lake and an oligotrophic polyhumic lake showed that the abundance of high-quality phytoplankton (cryptophytes, chrysophytes, diatoms) among total particulate organic carbon was minor (8.7% [SD 2.4%] and 6.5% [7.0%]). We modeled <i>Daphnia</i> diets (i.e., resource assimilation) using a fatty acid mixing model. Our analyses showed that <i>Daphnia</i> were able to locate high-quality algae (cryptophytes, chrysophytes, and diatoms) more effectively during cyanobacteria blooms in a eutrophic lake (55% [SD 12%]) than in a polyhumic lake (25% [10%]). Nevertheless, our results show that intense eutrophication and browning diminish assimilation of high quality algae, limiting <i>Daphnia</i> biomass production.
DOI: 10.6084/m9.figshare.8667821.v2
title: Trophic state index validation based on the phytoplankton functional group approach in Amazon floodplain lakes

description: Many trophic indices have been constructed for temperate aquatic environments, but few have proved reliable for tropical environments. Indices constructed on the basis of nutrients may not be effective for describing the trophic state because the fractions of nitrogen and phosphorus differ in their potential to predict the nutrient limitation in tropical aquatic environments. We developed an index based on the phytoplankton Reynolds functional groups for an Amazonian floodplain lake from samples collected during 2 contrasting hydrological periods (rising and flushing) and compared it with the index initially proposed by Carlson in 1977 and further adapted to tropical environments by Toledo in 1990. The functional group and Carlson indices matched only 37% and 56% of the sample units collected during the rising and flushing periods, respectively. Our study confirms the difficulty of assessing trophic states using only phosphorus and chlorophyll <i>a</i> in tropical floodplain lakes. In this environment (1) nitrogen may significantly limit phytoplankton growth and (2) complex phytoplankton–nutrient relationships occur during the hydrological cycle that cannot be accounted for through a simple phosphorus and chlorophyll <i>a</i> formula.
DOI: 10.6084/m9.figshare.8667821.v1
title: Trophic state index validation based on the phytoplankton functional group approach in Amazon floodplain lakes

description: Many trophic indices have been constructed for temperate aquatic environments, but few have proved reliable for tropical environments. Indices constructed on the basis of nutrients may not be effective for describing the trophic state because the fractions of nitrogen and phosphorus differ in their potential to predict the nutrient limitation in tropical aquatic environments. We developed an index based on the phytoplankton Reynolds functional groups for an Amazonian floodplain lake from samples collected during 2 contrasting hydrological periods (rising and flushing) and compared it with the index initially proposed by Carlson in 1977 and further adapted to tropical environments by Toledo in 1990. The functional group and Carlson indices matched only 37% and 56% of the sample units collected during the rising and flushing periods, respectively. Our study confirms the difficulty of assessing trophic states using only phosphorus and chlorophyll <i>a</i> in tropical floodplain lakes. In this environment (1) nitrogen may significantly limit phytoplankton growth and (2) complex phytoplankton–nutrient relationships occur during the hydrological cycle that cannot be accounted for through a simple phosphorus and chlorophyll <i>a</i> formula.
DOI: 10.6084/m9.figshare.8667809.v2
title: Eutrophication and browning influence <i>Daphnia</i> nutritional ecology

description: Climate change and land-use practices can enhance lake eutrophication and browning, which influence phytoplankton composition by decreasing the availability of food high in nutritional quality (algae) and increasing the abundance of low-quality food (terrestrial detritus, bacteria) for herbivorous zooplankton. Nutritionally valuable algae for zooplankton are rich in essential biomolecules such as amino acids, polyunsaturated fatty acids (PUFAs), sterols, and phosphorus. We performed laboratory experiments and showed a stronger positive relationship between zooplankton (<i>Daphnia</i>) cumulative offspring number and availability of high-quality algae (Cryptophytes: <i>Rhodomonas/Cryptomonas</i>; and Chrysophytes: <i>Mallomonas</i>) than with intermediate-quality (Chlorophytes: <i>Acutodesmus</i>) or poor-quality (Dinoflagellates: <i>Peridinium</i>) algae. The higher cumulative offspring number of <i>Daphnia</i> was a result of higher amounts of total ω-3 and ω-6 PUFA, proteins, sterols, and amino acids in the algal diets. The experiments also showed that even a small addition of high-quality algae (<i>Rhodomonas</i>) to intermediate-quality (<i>Acutodesmus</i>) or low-quality (bacteria, heterotrophic nanoflagellates, or terrestrial organic matter) diets can enhance the <i>Daphnia</i> cumulative offspring production. Our carbon mass balance calculation for a eutrophic clearwater lake and an oligotrophic polyhumic lake showed that the abundance of high-quality phytoplankton (cryptophytes, chrysophytes, diatoms) among total particulate organic carbon was minor (8.7% [SD 2.4%] and 6.5% [7.0%]). We modeled <i>Daphnia</i> diets (i.e., resource assimilation) using a fatty acid mixing model. Our analyses showed that <i>Daphnia</i> were able to locate high-quality algae (cryptophytes, chrysophytes, and diatoms) more effectively during cyanobacteria blooms in a eutrophic lake (55% [SD 12%]) than in a polyhumic lake (25% [10%]). Nevertheless, our results show that intense eutrophication and browning diminish assimilation of high quality algae, limiting <i>Daphnia</i> biomass production.
DOI: 10.6084/m9.figshare.8667800
title: Verification of NGS findings by Sanger sequencing

description: These data include verification analyses of targeted NGS findings using Sanger sequencing.Family-based approach: 2 affected probands (1,2), one healthy brother (3), mother, father.
DOI: 10.6084/m9.figshare.8667815.v2
title: RADseq of yellow perch for diversity assess

description: We applied restriction site-associated DNA sequencing (RAD-Seq) to yellow perch geographic demes to develop large numbers of polymorphic genetic markers, including single nucleotide polymorphisms and simple sequence repeats, and to evaluate nucleotide diversity. A total of 258,056 contigs were assembled with the length of 605 ± 71 (mean ± SD) bp, which were longer than those just using HiSeq data. Nucleotide diversity (π) was 0.00304 with 95% confidence intervals from 0.00303 to 0.00304. Based on the assembled sequences, a total of 59,766 perfect single sequence repeats were detected, with AC/GT being the most common repeat motif and GC being the rarest. Based on this breeding population, 41,736 high-quality single nucleotide polymorphisms and 10,412 polymorphic single sequence repeats were obtained. Validation of amplification by randomly selecting 40 polymorphic single sequence repeats showed a high success rate (85%).
DOI: 10.6084/m9.figshare.8667809.v1
title: Eutrophication and browning influence <i>Daphnia</i> nutritional ecology

description: Climate change and land-use practices can enhance lake eutrophication and browning, which influence phytoplankton composition by decreasing the availability of food high in nutritional quality (algae) and increasing the abundance of low-quality food (terrestrial detritus, bacteria) for herbivorous zooplankton. Nutritionally valuable algae for zooplankton are rich in essential biomolecules such as amino acids, polyunsaturated fatty acids (PUFAs), sterols, and phosphorus. We performed laboratory experiments and showed a stronger positive relationship between zooplankton (<i>Daphnia</i>) cumulative offspring number and availability of high-quality algae (Cryptophytes: <i>Rhodomonas/Cryptomonas</i>; and Chrysophytes: <i>Mallomonas</i>) than with intermediate-quality (Chlorophytes: <i>Acutodesmus</i>) or poor-quality (Dinoflagellates: <i>Peridinium</i>) algae. The higher cumulative offspring number of <i>Daphnia</i> was a result of higher amounts of total ω-3 and ω-6 PUFA, proteins, sterols, and amino acids in the algal diets. The experiments also showed that even a small addition of high-quality algae (<i>Rhodomonas</i>) to intermediate-quality (<i>Acutodesmus</i>) or low-quality (bacteria, heterotrophic nanoflagellates, or terrestrial organic matter) diets can enhance the <i>Daphnia</i> cumulative offspring production. Our carbon mass balance calculation for a eutrophic clearwater lake and an oligotrophic polyhumic lake showed that the abundance of high-quality phytoplankton (cryptophytes, chrysophytes, diatoms) among total particulate organic carbon was minor (8.7% [SD 2.4%] and 6.5% [7.0%]). We modeled <i>Daphnia</i> diets (i.e., resource assimilation) using a fatty acid mixing model. Our analyses showed that <i>Daphnia</i> were able to locate high-quality algae (cryptophytes, chrysophytes, and diatoms) more effectively during cyanobacteria blooms in a eutrophic lake (55% [SD 12%]) than in a polyhumic lake (25% [10%]). Nevertheless, our results show that intense eutrophication and browning diminish assimilation of high quality algae, limiting <i>Daphnia</i> biomass production.
DOI: 10.6084/m9.figshare.8667800.v1
title: Verification of NGS findings by Sanger sequencing

description: These data include verification analyses of targeted NGS findings using Sanger sequencing.Family-based approach: 2 affected probands (1,2), one healthy brother (3), mother, father.
DOI: 10.6084/m9.figshare.8667815.v3
title: RADseq of yellow perch for diversity assess

description: We applied restriction site-associated DNA sequencing (RAD-Seq) to yellow perch geographic demes to develop large numbers of polymorphic genetic markers, including single nucleotide polymorphisms and simple sequence repeats, and to evaluate nucleotide diversity. A total of 258,056 contigs were assembled with the length of 605 ± 71 (mean ± SD) bp, which were longer than those just using HiSeq data. Nucleotide diversity (π) was 0.00304 with 95% confidence intervals from 0.00303 to 0.00304. Based on the assembled sequences, a total of 59,766 perfect single sequence repeats were detected, with AC/GT being the most common repeat motif and GC being the rarest. Based on this breeding population, 41,736 high-quality single nucleotide polymorphisms and 10,412 polymorphic single sequence repeats were obtained. Validation of amplification by randomly selecting 40 polymorphic single sequence repeats showed a high success rate (85%).
DOI: 10.6084/m9.figshare.8667815.v5
title: RAD-Seq of yellow perch for diversity assessment

description: We applied restriction site-associated DNA sequencing (RAD-Seq) to yellow perch geographic demes to develop large numbers of polymorphic genetic markers, including single nucleotide polymorphisms and simple sequence repeats, and to evaluate nucleotide diversity. A total of 258,056 contigs were assembled with the length of 605 ± 71 (mean ± SD) bp, which were longer than those just using HiSeq data. Nucleotide diversity (π) was 0.00304 with 95% confidence intervals from 0.00303 to 0.00304. Based on the assembled sequences, a total of 59,766 perfect single sequence repeats were detected, with AC/GT being the most common repeat motif and GC being the rarest. Based on this breeding population, 41,736 high-quality single nucleotide polymorphisms and 10,412 polymorphic single sequence repeats were obtained. Validation of amplification by randomly selecting 40 polymorphic single sequence repeats showed a high success rate (85%).
DOI: 10.6084/m9.figshare.8667815.v4
title: RAD-Seq of yellow perch for diversity assessment

description: We applied restriction site-associated DNA sequencing (RAD-Seq) to yellow perch geographic demes to develop large numbers of polymorphic genetic markers, including single nucleotide polymorphisms and simple sequence repeats, and to evaluate nucleotide diversity. A total of 258,056 contigs were assembled with the length of 605 ± 71 (mean ± SD) bp, which were longer than those just using HiSeq data. Nucleotide diversity (π) was 0.00304 with 95% confidence intervals from 0.00303 to 0.00304. Based on the assembled sequences, a total of 59,766 perfect single sequence repeats were detected, with AC/GT being the most common repeat motif and GC being the rarest. Based on this breeding population, 41,736 high-quality single nucleotide polymorphisms and 10,412 polymorphic single sequence repeats were obtained. Validation of amplification by randomly selecting 40 polymorphic single sequence repeats showed a high success rate (85%).
DOI: 10.6084/m9.figshare.8665661.v1
title: Data

description: Genotype and phenotype data sets<br>
DOI: 10.6084/m9.figshare.8653577
title: Supplementary data - Both TRPV1 and TRPA1 channels are involved downstream of H4R-induced itch.pdf

description: Supplementary data to the manuscript "Both TRPV1 and TRPA1 channels are involved downstream of H4R-induced itch"
DOI: 10.6084/m9.figshare.8653577.v1
title: Supplementary data - Both TRPV1 and TRPA1 channels are involved downstream of H4R-induced itch.pdf

description: Supplementary data to the manuscript "Both TRPV1 and TRPA1 channels are involved downstream of H4R-induced itch"
DOI: 10.6084/m9.figshare.8638094
title: Remarks on <i>p</i>-cyclically monotone operators

description: In this paper, we deal with three aspects of <i>p</i>-cyclically monotone operators. First, we introduce a notion of monotone polar adapted for <i>p</i>-cyclically monotone operators and study these kinds of operators with a unique maximal extension (called pre-maximal), and with a convex graph. We then deal with linear operators and provide characterizations of <i>p</i>-cyclical monotonicity and maximal <i>p</i>-cyclical monotonicity. Finally, we show that the Brézis-Browder theorem preserves <i>p</i>-cyclical monotonicity in reflexive Banach spaces.
DOI: 10.6084/m9.figshare.8638094.v1
title: Remarks on <i>p</i>-cyclically monotone operators

description: In this paper, we deal with three aspects of <i>p</i>-cyclically monotone operators. First, we introduce a notion of monotone polar adapted for <i>p</i>-cyclically monotone operators and study these kinds of operators with a unique maximal extension (called pre-maximal), and with a convex graph. We then deal with linear operators and provide characterizations of <i>p</i>-cyclical monotonicity and maximal <i>p</i>-cyclical monotonicity. Finally, we show that the Brézis-Browder theorem preserves <i>p</i>-cyclical monotonicity in reflexive Banach spaces.