cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.5993215.v1
title: Shared metamorphic histories of various Palaeoproterozoic granulites from Datong–Huai’an area, North China Craton (NCC): constraints from zircon U–Pb ages and petrology

description: Different tectonic interpretations have been proposed for the various spatially associated Palaeoproterozoic granulite-facies lithologies (metasedimentary rocks, metabasites, and felsic granulites) from north-central part of the North China Craton, which hinges primarily on controversies about metamorphic histories of these granulites, especially on the timing of peak metamorphism. Published data exhibit two controversial peak metamorphic ages of 1950–1900 Ma and 1850–1800 Ma. We report here LA-ICPMS U–Pb zircon ages of seven representative granulite-facies samples of different lithologies to constrain the timing of metamorphism, and then discuss their geological significance. Most zircon grains from these rocks display weak core-and-rim structures and yield two comparable group metamorphic ages of 1970–1900 Ma and 1880–1790 Ma, although their formation ages vary from Neoarchaean to Palaeoproterozoic. The older population metamorphic ages are interpreted to approximate timing of high-pressure granulite-facies metamorphism, and the younger population ages as the approximate timing of intermediate- to low-pressure granulite-facies metamorphism. Combined with recent petrological studies, we propose these granulites have shared metamorphic histories at least since ~1970–1900 Ma, and they are probably formed in one single metamorphic cycle in response to crustal-scale subduction–collision–exhumation processes involved in Palaeoproterozoic mobile belt.
DOI: 10.6084/m9.figshare.14906071.v1
title: Additional file 7 of Characterization of a ferroptosis and iron-metabolism related lncRNA signature in lung adenocarcinoma

description: Additional file 7: Table S3. 118 Ferroptosis and iron-metabolism related lncRNAs.
DOI: 10.6084/m9.figshare.14381740.v1
title: <i>In vitro</i> and <i>in vivo</i> antitumor effects of lupeol-loaded galactosylated liposomes

description: Lupeol liposomes, modified with Gal-PEG-DSPE, were developed following a thin-film dispersion method. Then, the morphology, physicochemical properties, and <i>in vitro</i> release properties of those liposomes were investigated. The scanning electron microscopic images showed that most of the liposomes were spherical particles; they were similar in size and uniformly dispersed. Both lupeol liposomes and Gal-lupeol liposomes exhibited an average particle size of about 100 nm. The encapsulation efficiency was greater than 85%. The encapsulation efficiency of lupeol liposome and Gal-lupeol liposome, stored with 15% sucrose as glycoprotein for 6 months, was higher than 80%; although the particle size increased, they remained within 200 nm. The cell-uptake study demonstrated that the Gal-lupeol-liposome uptake efficiency was the highest in HepG2 cells. The HepG2 cells treated with the Gal-lupeol liposomes had higher apoptotic efficiency than the lupeol liposome and free lupeol. After HepG2 cells were treated with Gal-lupeol liposome, the expressions of AKT/mTOR-related proteins (p-AKT308 and p-AKT473) were also significantly reduced than the lupeol-liposome and free lupeol group. The <i>in vivo</i> targeting studies showed that Gal-NR-L exhibited liver-targeting effects on FVB mice. The pharmacodynamic study was performed by transfecting AKT and c-MET via the high-pressure tail vein of FVB mice. After Gal-lupeol-L administration, the liver index and liver weight of mice were less than those non-targeted group. The histopathological study showed that the lobular structure in the mice liver was clearer, the vacuoles were more obvious, and the cytoplasm was more abundant after Gal-lupeol-L administration. Also, the qRT-PCR study showed that AFP, GPC3, and EpCAM mRNA expression levels were significantly lower than those non-targeted lupeol-liposomes.
DOI: 10.6084/m9.figshare.5993218.v1
title: Traumatic extracranial internal carotid-jugular fistula leading to serious injury: a case report in forensic assessment

description: Extracranial carotid artery injuries may produce severe haemorrhage, cerebral damage or arteriovenous fistula. Examples of traumatic extracranial carotid-jugular fistula are not frequently reported, especially in forensic medicine. We report a controversial case of an extracranial internal carotid-jugular fistula resulting from a stab wound to the neck. The degree of the injury was classified under “The Standard of Human Body Injury Assessment (2014)” (SIA) in China by forensic examiners. We believe this case report will provide information for the forensic assessment of similar cases.
DOI: 10.6084/m9.figshare.5993218
title: Traumatic extracranial internal carotid-jugular fistula leading to serious injury: a case report in forensic assessment

description: Extracranial carotid artery injuries may produce severe haemorrhage, cerebral damage or arteriovenous fistula. Examples of traumatic extracranial carotid-jugular fistula are not frequently reported, especially in forensic medicine. We report a controversial case of an extracranial internal carotid-jugular fistula resulting from a stab wound to the neck. The degree of the injury was classified under “The Standard of Human Body Injury Assessment (2014)” (SIA) in China by forensic examiners. We believe this case report will provide information for the forensic assessment of similar cases.
DOI: 10.6084/m9.figshare.14906065
title: Additional file 5 of Characterization of a ferroptosis and iron-metabolism related lncRNA signature in lung adenocarcinoma

description: Additional file 5: Table S1. Ferroptosis and iron-metabolism related genes.
DOI: 10.18712/nsd-nsd1933-v2
title: Health, Environment and Lifestyle Among Youth in Sogn og Fjordane, 2012

description: The purpose of this project was to obtain data that could be used to promote health, well-being, social and environmental conditions, to prevent mental and somatic illness, injury or suffering, and to contribute to the equalization of social health inequalities. The project addresses in particular two important challenges for which more research is needed. First, that more and more young people are obese and overweight. In addition, too many Norwegian young people do not complete upper secondary school and thus are more exposed to health problems as adults. The main objective was to investigate self-reported health and quality of life as well as factors that can influence this. The study was carried out as a collaboration between Sogn og Fjordane County Municipality, the municipalities of upper secondary schools in Sogn og Fjordane, Sogn og Fjordane University College, Helse Førde and the University of Bergen.
DOI: 10.6084/m9.figshare.12284624.v1
title: Additional file 3 of Impact of coronary collateralization on long-term clinical outcomes in type 2 diabetic patients after successful recanalization of chronic total occlusion

description: Additional file 3: Table S3. Predictors of MACCE and repeat revascularization in patients with T2DM on univariable and multivariable analysis.
DOI: 10.6084/m9.figshare.12284606
title: Additional file 1 of Impact of coronary collateralization on long-term clinical outcomes in type 2 diabetic patients after successful recanalization of chronic total occlusion

description: Additional file 1: Table S1. Predictors of MACCE and repeat revascularization in all patients on univariable and multivariable analysis.
DOI: 10.6084/m9.figshare.12284624
title: Additional file 3 of Impact of coronary collateralization on long-term clinical outcomes in type 2 diabetic patients after successful recanalization of chronic total occlusion

description: Additional file 3: Table S3. Predictors of MACCE and repeat revascularization in patients with T2DM on univariable and multivariable analysis.
DOI: 10.4121/858870bc-ce57-4782-8ee6-48cfd171db63
title: Data underlying the publication: High-throughput mechanophenotyping of multicellular spheroids using a microfluidic micropipette aspiration chip

description: Research paper published in Lab on a Chip, on the development of a microfluidic chip that allows high-throughput aspiration of multicellular spheroids to characterize tissue mechanics. Data includes Excel files with measured spheroid mechanical parameters such as their elasticity and viscosity. Additionally, the Python codes used for analysis and the AutoCAD files including the microfluidic chip designs are included.
DOI: 10.6084/m9.figshare.14906068.v1
title: Additional file 6 of Characterization of a ferroptosis and iron-metabolism related lncRNA signature in lung adenocarcinoma

description: Additional file 6: Table S2. Primers sequences in qRT-PCR.
DOI: 10.25402/fsg.22770626
title: Kosakonia radicincitans with hypervirulent lON genes causes human bloodstream infections - supplementary - materials

description: Kosakonia radicincitans is a species within the new genus Kosakonia, which is typically a plant pathogen,
with rare reports of human infection. The number of human infections may be underestimated
because this new genus is under-represented among diagnostic tools. This report describes a case of
bloodstream infection caused by K. radicincitans. The pathogen was identified by matrix-assisted laser
desorption/ionization-TOF mass spectrometry and 16S rRNA gene sequencing. The hypervirulent human
pathogenicity gene LON, which has not been described before, was detected in the bacterial genome by
gene annotation. Thus, this discovery provides a new reference for studying the pathogenic mechanism
of this rare pathogen.
DOI: 10.6084/m9.figshare.14906074.v1
title: Additional file 8 of Characterization of a ferroptosis and iron-metabolism related lncRNA signature in lung adenocarcinoma

description: Additional file 8: Table S4. The results of univariate and multivariate Cox regression analysis performed to compare prognostic value of previously published signatures with LncSig developed in this study.
DOI: 10.5281/zenodo.10210034
title: Fusion of Single and Integral Multispectral Aerial Images

description: Abstract: An adequate fusion of the most significant salient information from multiple input channels is essential for many aerial imaging tasks. While multispectral recordings reveal features in various spectral ranges, synthetic aperture sensing makes occluded features visible. We present a first and hybrid (model- and learning-based) architecture for fusing the most significant features from conventional aerial images with the ones from integral aerial images that are the result of synthetic aperture sensing for removing occlusion. It combines the environment’s spatial references with features of unoccluded targets that would normally be hidden by dense vegetation. Our method outperforms state-of-the-art two-channel and multi-channel fusion approaches visually and quantitatively in common metrics, such as mutual information, visual information fidelity, and peak signal-to-noise ratio. The proposed model does not require manually tuned parameters, can be extended to an arbitrary number and arbitrary combinations of spectral channels, and is reconfigurable for addressing different use cases. We demonstrate examples for search and rescue, wildfire detection, and wildlife observation.
DOI: 10.5281/zenodo.10210035
title: Fusion of Single and Integral Multispectral Aerial Images

description: Abstract: We present a novel hybrid (model- and learning-based) architecture for fusing the most significant features from conventional aerial images and integral aerial images that result from synthetic aperture sensing for removing occlusion caused by dense vegetation. It combines the environment's spatial references with features of unoccluded targets. Our method out-beats the state-of-the-art, does not require manually tuned parameters, can be extended to an arbitrary number and combinations of spectral channels, and is reconfigurable to address different use-cases.
DOI: 10.5281/zenodo.10371831
title: Fusion of Single and Integral Multispectral Aerial Images

description: Abstract: We present a novel hybrid (model- and learning-based) architecture for fusing the most significant features from conventional aerial images and integral aerial images that result from synthetic aperture sensing for removing occlusion caused by dense vegetation. It combines the environment's spatial references with features of unoccluded targets. Our method out-beats the state-of-the-art, does not require manually tuned parameters, can be extended to an arbitrary number and combinations of spectral channels, and is reconfigurable to address different use-cases.
DOI: 10.5281/zenodo.10450971
title: Fusion of Single and Integral Multispectral Aerial Images

description: Abstract: An adequate fusion of the most significant salient information from multiple input channels is essential for many aerial imaging tasks. While multispectral recordings reveal features in various spectral ranges, synthetic aperture sensing makes occluded features visible. We present a first and hybrid (model- and learning-based) architecture for fusing the most significant features from conventional aerial images with the ones from integral aerial images that are the result of synthetic aperture sensing for removing occlusion. It combines the environment’s spatial references with features of unoccluded targets that would normally be hidden by dense vegetation. Our method outperforms state-of-the-art two-channel and multi-channel fusion approaches visually and quantitatively in common metrics, such as mutual information, visual information fidelity, and peak signal-to-noise ratio. The proposed model does not require manually tuned parameters, can be extended to an arbitrary number and arbitrary combinations of spectral channels, and is reconfigurable for addressing different use cases. We demonstrate examples for search and rescue, wildfire detection, and wildlife observation.
DOI: 10.6084/m9.figshare.12284711.v1
title: Additional file 4 of Chromatin topology reorganization and transcription repression by PML-RARα in acute promyeloid leukemia

description: Additional file 4:Table S4. Differential expression of genes (267) affected by PML-RARα in PR9 cells.
DOI: 10.6084/m9.figshare.16613797.v2
title: The microRNA-451a/chromosome segregation 1-like axis suppresses cell proliferation, migration, and invasion and induces apoptosis in nasopharyngeal carcinoma

description: MicroRNA-451a (miR-451a) has been implicated in the initiation and progression of multiple cancers. However, the regulatory mechanisms underlying its function in nasopharyngeal carcinoma (NPC) are poorly understood. Thus, we investigated in detail the role of the microRNA-451a/chromosome segregation 1-like (miR-45a/CSE1L) axis and its regulatory mechanism in NPC. We examined the levels of miR-451a and CSE1L in NPC, and assessed the effects of miR-451a and CSE1L on NPC by cell functional experiments. Furthermore, we elucidated the direct regulatory effect of miR-451a on <i>CSE1L</i> by the luciferase reporter assay, RNA pull-down assay, and RNA immunoprecipitation and validated our observations by calculating the Pearson’s correlation coefficient. We found that miR-451a was down-regulated in NPC cells, and its over-expression attenuated cell proliferation, migration, and invasion, and tumor growth in 5–8 F and SUNE-1 cells and promoted apoptosis. Moreover, <i>CSE1L</i> was the direct gene target of miR-451a, and its over-expression abrogated miR-451a-dependent inhibition of malignancy in 5–8 F and SUNE-1 cells. The Pearson’s correlation coefficient indicated a negative correlation between <i>CSE1L</i> and miR-451a. miR-451a serves as a tumor suppressor and targets <i>CSE1L</i>. miR-451a suppresses <i>CSE1L</i> expression, thereby reducing proliferation, invasion, and migration and increasing apoptosis of NPC cells.
DOI: 10.6084/m9.figshare.21192087.v1
title: Additional file 4 of circ_0086296 induced atherosclerotic lesions via the IFIT1/STAT1 feedback loop by sponging miR-576-3p

description: Additional file 4. Basic characteristics of the differently expressed mRNAs.
DOI: 10.6084/m9.figshare.21192090.v1
title: Additional file 5 of circ_0086296 induced atherosclerotic lesions via the IFIT1/STAT1 feedback loop by sponging miR-576-3p

description: Additional file 5. The binding site of circRNAs and miRNAs.
DOI: 10.6084/m9.figshare.21197987.v1
title: A Bayesian Partially Observable Online Change Detection Approach with Thompson Sampling

description: This article proposes a Bayesian learning framework for online change detection of high-dimensional data streams where only a subset of variables can be observed at each time point due to limited sensing capacities. On the one hand, we need to build a change detection scheme based on partial observations. On the other, the scheme should be able to adaptively and actively select the most critical sensing variables to observe to maximize the detection power. To address these two points, in this article, first, a novel Bayesian Spike-Slab Composite Decomposition (BSSCD) is proposed to decompose the high-dimensional signals onto normal and abnormal bases, where the projection coefficients are efficiently estimated via variational Bayesian inference. Built upon it, the posterior Bayes factor is constructed as the detection statistic. Second, by further formulating the detection statistic as the reward function of combinatorial multi-armed bandit (CMAB), a Thompson sampling strategy is proposed for selecting the potential changed variables with the balance of exploration and exploitation. The efficacy and applicability of our method are demonstrated in practice with numerical studies and a real case study.
DOI: 10.6084/m9.figshare.21192097.v1
title: Additional file 1 of Relationship between sarcopenia/paravertebral muscles and the incidence of vertebral refractures following percutaneous kyphoplasty: a retrospective study

description: Additional file 1.
DOI: 10.6084/m9.figshare.20681299
title: Paenibacillus dendrobii sp. nov., an indole-3-acetic acid-producing endophytic bacterium isolated from Dendrobium nobile

description: The genome sequence, the respiratory quinone and the  cellular fatty acids of  <em>Paenibacillus dendrobii</em>  HJL-G12T.
DOI: 10.6084/m9.figshare.23827038
title: Table S1-S8, Figure S1-S3, and Supplementary text for Detrital zircon REE and tectonic settings (20230803-1)

description: Text S1: Detailed sample descriptions and analytical methods.Fig. S1 Tectonic framework of the Lhasa terrane (modified from Zhu et al., 2011), showing the sampling locations.Fig. S2 Photographs(A and B) and photomicrographs(C and D) of the paragneisses from the Nyainqentanglha Groupand Nyingchi Complex. Q = quartz; Pl = plagioclase; L = lithics; Bt = biotite; M = muscovite.Fig. S3 Concordia plots and typical cathodoluminescence images of zircons from the paragneisses of the Nyainqentanglha Groupand Nyingchi Complex. n = total number of analyses. The data filtering rules are consistent with those of Fig. 4. The data are available in Table S7. The dashed circles represent the locations of U-Pb dating and REE analyses. Green andblue numbers represent the zircon 206Pb/238U agesand analytical numbers, respectively.Table S1 U-Pb dating and REE data of detrital zircons from typical modern tectonic settings and their calculation results.Table S2 U-Pb dating and REE data of detrital zircons from the modern river sands in the USA and their calculation results.Table S3 U-Pb dating and REE data of detrital zircons from the Late Permian sediments, SW China and their calculation results.Table S4 U-Pb dating and REE data of detrital zircons from major continents in the world and their calculation results.Table S5 Summary of the records of the branches of the Neo-Tethyan, Paleo-Tethyan, and Proto-Tethyan oceans in the Lhasa terrane.Table S6 Summary of compiled detrital zircon REE samples of the Lhasa terrane.Table S7 U-Pb dating and REE data of detrital zircons from the Lhasa terrane and their calculation results.Table S8 U-Pb age and REE analysis results of standard zircons.
DOI: 10.6084/m9.figshare.7862042
title: Efficacy and safety of guselkumab, administered with a novel patient-controlled injector (One-Press), for moderate-to-severe psoriasis: results from the phase 3 ORION study

description: <b>Objectives:</b> Guselkumab, an interleukin-23 antagonist, is approved for self-administration with the UltraSafe Plus™ syringe to treat moderate-to-severe plaque-type psoriasis. We evaluated the efficacy, safety, pharmacokinetics, and acceptability of guselkumab administered using a novel patient-controlled injector (One-Press) in psoriasis patients. <b>Materials and methods:</b> This Phase 3, multicentre, double-blind, placebo-controlled study (ORION, Clinicaltrials.gov identifier-NCT02905331) randomized adults with moderate-to-severe psoriasis (4:1) to guselkumab 100 mg at Weeks 0/4/12/20/28 or placebo at Weeks 0/4/12 with crossover to guselkumab 100 mg at Weeks 16/20/28. Week 16 co-primary endpoints were the proportions of patients achieving Investigator Global Assessment (IGA) cleared/minimal (IGA 0/1) and Psoriasis Area and Severity Index 90% improvement (PASI90) responses. One-Press usability/acceptability was evaluated using the Self-Injection Assessment Questionnaire (SIAQ) and Patient-Controlled Injection Device Questionnaire. Final assessments occurred at Week 40. <b>Results:</b> At Week 16, significantly higher proportions of guselkumab-treated (<i>N</i> = 62) than placebo-treated (<i>N</i> = 16) patients achieved IGA 0/1 (80.6% vs. 0.0%, <i>p</i> &lt; .001) and PASI90 (75.8% vs. 0.0%, <i>p</i> &lt; .001) responses. Adverse events were comparable between treatments. SIAQ results demonstrated 99% (68/69) of patients were satisfied/very satisfied with One-Press at Week 28. <b>Conclusions:</b> Guselkumab administered using the One-Press patient-controlled injector was efficacious and well-tolerated in moderate-to-severe psoriasis patients, consistent with previously reported Phase-3 studies of guselkumab administered using UltraSafe Plus. One-Press was highly acceptable to patients.
DOI: 10.6084/m9.figshare.7862042.v1
title: Efficacy and safety of guselkumab, administered with a novel patient-controlled injector (One-Press), for moderate-to-severe psoriasis: results from the phase 3 ORION study

description: <b>Objectives:</b> Guselkumab, an interleukin-23 antagonist, is approved for self-administration with the UltraSafe Plus™ syringe to treat moderate-to-severe plaque-type psoriasis. We evaluated the efficacy, safety, pharmacokinetics, and acceptability of guselkumab administered using a novel patient-controlled injector (One-Press) in psoriasis patients. <b>Materials and methods:</b> This Phase 3, multicentre, double-blind, placebo-controlled study (ORION, Clinicaltrials.gov identifier-NCT02905331) randomized adults with moderate-to-severe psoriasis (4:1) to guselkumab 100 mg at Weeks 0/4/12/20/28 or placebo at Weeks 0/4/12 with crossover to guselkumab 100 mg at Weeks 16/20/28. Week 16 co-primary endpoints were the proportions of patients achieving Investigator Global Assessment (IGA) cleared/minimal (IGA 0/1) and Psoriasis Area and Severity Index 90% improvement (PASI90) responses. One-Press usability/acceptability was evaluated using the Self-Injection Assessment Questionnaire (SIAQ) and Patient-Controlled Injection Device Questionnaire. Final assessments occurred at Week 40. <b>Results:</b> At Week 16, significantly higher proportions of guselkumab-treated (<i>N</i> = 62) than placebo-treated (<i>N</i> = 16) patients achieved IGA 0/1 (80.6% vs. 0.0%, <i>p</i> &lt; .001) and PASI90 (75.8% vs. 0.0%, <i>p</i> &lt; .001) responses. Adverse events were comparable between treatments. SIAQ results demonstrated 99% (68/69) of patients were satisfied/very satisfied with One-Press at Week 28. <b>Conclusions:</b> Guselkumab administered using the One-Press patient-controlled injector was efficacious and well-tolerated in moderate-to-severe psoriasis patients, consistent with previously reported Phase-3 studies of guselkumab administered using UltraSafe Plus. One-Press was highly acceptable to patients.