cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.11391201.v1
title: New Ringer's lactate gel formulation on nasal comfort and humidification

description: Abstract Introduction: The use of saline irrigation for nasal washes is a well established procedure in the treatment of sinonasal inflammation and infection. In addition to saline solutions, Ringer's lactate is also an efficient option for nasal washes and humidification. Objective: To assess the comfort, humidification and tolerance regarding stinging sensation, provided by sodium chloride nasal gel at the concentrations of 4.5 mg/g and 6.0 mg/g through questionnaires answered by the patients. Methods: A total of 60 patients, 56 females, aged between 22 and 66 years old (mean age of 47) and 4 males, aged between 36 and 66 years (mean age of 49), were included in the study for a period of 17 days (±2 days) treatment. The patients were monitored by a general practitioner throughout the study period. They were instructed to apply each product in both nostrils twice a day during a 7-day period (±2 days). The patients were evaluated prior to the use of the first product at visit 0 (V0), after 7 days of treatment (±2 days) at visit 1 (V1), after 3 days of product discontinuation at visit 2 (V2) and after 7 days (±2 days) of treatment with the second product, in visit 3 (V3). Results: A significant difference (5% significance) was observed regarding comfort and stinging sensation between the two different concentrations; comfort was higher and stinging was lower with the 6.0 mg/g concentration gel. No difference in humidification was observed between the two treatments. Conclusion: Ringer's lactate at the concentration of 6.0 mg/g was superior to that at 4.5 mg/g for parameters comfort and stinging sensation. No statistical difference was observed between the two products regarding nasal humidification.
DOI: 10.6084/m9.figshare.11390991.v1
title: Learning curve for endoscopic evaluation of vocal folds lesions with narrow band imaging

description: Abstract Introduction: The endoscopic methods are progressing and becoming more common in routine clinical diagnosis in the field of otorhinolaryngology. Relatively large amount of researches have proved high accuracy of narrow band imaging endoscopy in differentiating benign and malignant lesions within vocal folds. However, little is known about learning curve in narrow band imaging evaluation of laryngeal lesions. Objective: The aim of this study was to determine the learning curve for the narrow band imaging evaluation of vocal folds pathologies depending on the duration of the procedure. Methods: Records of 134 narrow band imaging that were analyzed in terms of the duration of the procedure and the accuracy of diagnosis confirmed by histopathological diagnosis were enrolled in the study. The narrow band imaging examinations were performed sequentially by one investigator over a period of 18 months. Results: The average duration of narrow band imaging recordings was 127.82 s. All 134 studies were divided into subsequent series of several elements. An evident decrease in time of investigation was noticed between 13th and 14th series, when the examinations were divided into 5 elements series, which corresponds to the difference between 65th and 70th subsequent narrow band imaging examination. Parallel groups of 67 examinations were created. Group 1 included 1st to 67th subsequent narrow band imaging examination; Group 2 – 68th to 134th narrow band imaging examinations. The non-parametric U Mann–Whitney test confirmed statistically significant difference between the mean duration of narrow band imaging examination in both groups 160.5 s and 95.1 s, respectively (p &lt; 10−7). Sensitivity and specificity of narrow band imaging examination in the first group were respectively: 83.7% and 76.7%. In the second group, these indicators amounted 98.1% and 80% respectively. Conclusions: A minimum of 65th–70th narrow band imaging examinations are required to reach a plateau phase of the learning process in assessment of glottis lesions. Analysis of learning curves is useful for the development of training programs and determination of a mastery level.
DOI: 10.6084/m9.figshare.11390703
title: Increased expression of pendrin in eosinophilic chronic rhinosinusitis with nasal polyps

description: Abstract Introduction: Chronic rhinosinusitis with nasal polyps is a heterogeneous disease and appropriate diagnostic algorithms in individual cases are necessary for effective medical treatment. Objective: The purpose of this study was to clarify the relationship between the pendrin expression of nasal polyps and clinical and pathological characteristic features of eosinophilic chronic rhinosinusitis. Methods: A total of 68 patients were classified into eosinophilic chronic rhinosinusitis or non-eosinophilic chronic rhinosinusitis groups according to the degree of eosinophilic infiltration into the nasal polyps. Clinical, hematological, and immunohistochemical analyses were performed and statistically compared between both groups. Results: Thirty-eight were classified into eosinophilic chronic rhinosinusitis and 30 into non-eosinophilic chronic rhinosinusitis groups. There were no significant differences in age distribution, sex ratio, prevalence of asthma, or any other complications between the groups. The mean Lund–Mackay score and the number of serum eosinophils was significantly higher in the eosinophilic chronic rhinosinusitis than in the non-eosinophilic chronic rhinosinusitis groups. The pendrin expression was more frequently detected in the epithelial surface layer of nasal polyps in the eosinophilic chronic rhinosinusitis than in the non-eosinophilic chronic rhinosinusitis groups. In addition, mucin 5AC was more widely expressed in the eosinophilic chronic rhinosinusitis than in the non-eosinophilic chronic rhinosinusitis. Conclusion: Increased expression of pendrin and mucin 5AC in the nasal polyps would be associated with development of eosinophilic chronic rhinosinusitis. This finding could allow the development of a novel therapeutic agent targeted specifically to patients with eosinophilic chronic rhinosinusitis.
DOI: 10.6084/m9.figshare.11390703.v1
title: Increased expression of pendrin in eosinophilic chronic rhinosinusitis with nasal polyps

description: Abstract Introduction: Chronic rhinosinusitis with nasal polyps is a heterogeneous disease and appropriate diagnostic algorithms in individual cases are necessary for effective medical treatment. Objective: The purpose of this study was to clarify the relationship between the pendrin expression of nasal polyps and clinical and pathological characteristic features of eosinophilic chronic rhinosinusitis. Methods: A total of 68 patients were classified into eosinophilic chronic rhinosinusitis or non-eosinophilic chronic rhinosinusitis groups according to the degree of eosinophilic infiltration into the nasal polyps. Clinical, hematological, and immunohistochemical analyses were performed and statistically compared between both groups. Results: Thirty-eight were classified into eosinophilic chronic rhinosinusitis and 30 into non-eosinophilic chronic rhinosinusitis groups. There were no significant differences in age distribution, sex ratio, prevalence of asthma, or any other complications between the groups. The mean Lund–Mackay score and the number of serum eosinophils was significantly higher in the eosinophilic chronic rhinosinusitis than in the non-eosinophilic chronic rhinosinusitis groups. The pendrin expression was more frequently detected in the epithelial surface layer of nasal polyps in the eosinophilic chronic rhinosinusitis than in the non-eosinophilic chronic rhinosinusitis groups. In addition, mucin 5AC was more widely expressed in the eosinophilic chronic rhinosinusitis than in the non-eosinophilic chronic rhinosinusitis. Conclusion: Increased expression of pendrin and mucin 5AC in the nasal polyps would be associated with development of eosinophilic chronic rhinosinusitis. This finding could allow the development of a novel therapeutic agent targeted specifically to patients with eosinophilic chronic rhinosinusitis.
DOI: 10.6084/m9.figshare.11390715
title: The effectiveness of eugenol against cisplatin-induced ototoxicity

description: Abstract Introduction: Ototoxicity refers to cellular damage or function impairment developing in the inner ear in association with any therapeutic agent or chemical substance, and still represents the principal side-effect restricting the use of cisplatin. Objective: The aim of this study was to perform a biochemical, functional and histopathological investigation of the potential protective effect of eugenol against cisplatin-induced ototoxicity. Methods: The study was performed with 24 female Sprague Dawley rats. Distortion product otoacoustic emissions tests were performed on all animals, which were randomized into four equal groups. A single intraperitoneal dose of 15 mg/kg cisplatin was administered to cisplatin group, while the eugenol group received 100 mg/kg eugenol intraperitoneal for five consecutive days. 100 mg/kg eugenol was administered to cisplatin + eugenol group for 5 days. On the third day, these rats were received a single dose of 15 mg/kg cisplatin. The control group was given 8 mL/kg/day intraperitoneal saline solution for five days. The distortion product otoacoustic emissions test was repeated 24 h after the final drug administration. All animals were sacrificed, and the cochleas were subsequently used for biochemical and histopathological examinations. Results: Cisplatin caused oxidative stress in the cochlea, impaired the cochlear structure and significantly reduced signal noise ratio levels. Administration of eugenol together with cisplatin reversed these effects and provided functional, biochemical and histopathological protection. Conclusion: The study findings represent the first indication in the literature that eugenol may protect against ototoxicity by raising levels of antioxidant enzymes and lowering those of oxidant parameters.
DOI: 10.6084/m9.figshare.11390715.v1
title: The effectiveness of eugenol against cisplatin-induced ototoxicity

description: Abstract Introduction: Ototoxicity refers to cellular damage or function impairment developing in the inner ear in association with any therapeutic agent or chemical substance, and still represents the principal side-effect restricting the use of cisplatin. Objective: The aim of this study was to perform a biochemical, functional and histopathological investigation of the potential protective effect of eugenol against cisplatin-induced ototoxicity. Methods: The study was performed with 24 female Sprague Dawley rats. Distortion product otoacoustic emissions tests were performed on all animals, which were randomized into four equal groups. A single intraperitoneal dose of 15 mg/kg cisplatin was administered to cisplatin group, while the eugenol group received 100 mg/kg eugenol intraperitoneal for five consecutive days. 100 mg/kg eugenol was administered to cisplatin + eugenol group for 5 days. On the third day, these rats were received a single dose of 15 mg/kg cisplatin. The control group was given 8 mL/kg/day intraperitoneal saline solution for five days. The distortion product otoacoustic emissions test was repeated 24 h after the final drug administration. All animals were sacrificed, and the cochleas were subsequently used for biochemical and histopathological examinations. Results: Cisplatin caused oxidative stress in the cochlea, impaired the cochlear structure and significantly reduced signal noise ratio levels. Administration of eugenol together with cisplatin reversed these effects and provided functional, biochemical and histopathological protection. Conclusion: The study findings represent the first indication in the literature that eugenol may protect against ototoxicity by raising levels of antioxidant enzymes and lowering those of oxidant parameters.
DOI: 10.6084/m9.figshare.11391285
title: Sleep quality assessment in chronic rhinosinusitis patients submitted to endoscopic sinus surgery: a meta-analysis

description: Abstract Introduction: Chronic rhinosinusitis can lead to poor sleep quality in affected individuals. Endoscopic nasal surgery has been indicated for patients with chronic rhinosinusitis, resulting in improved quality of life, but it is still unknown if there is a similar improvement in sleep quality after the surgical procedure. Objective: To estimate the sleep quality of patients with chronic rhinosinusitis after undergoing endoscopic sinus surgery. Methods: The literature search was conducted in the indexed databases PubMed, Embase, Lilacs, SciELO, Google Scholar, Web of Science, Scopus, Database of Thesis and Dissertations of CAPES, Cochrane Library, Clinical Trials and in the grey literature. It included studies that reported the sleep quality of patients with chronic rhinosinusitis after undergoing endoscopic sinus surgery based on questionnaires assessing quality of life. Two researchers independently conducted the study selection and extraction. The random effects model was chosen to conduct the meta-analysis that was performed using the statistical package STATA, version 11. Results: Overall, 4 studies and 509 subjects were included in the systematic review. Improved sleep quality was observed in 90% of the patients. There was an improvement (on average, from 57% to 67%) in each of the five symptoms related to sleep quality. The results of the meta-analysis revealed high heterogeneity. Conclusions: This review shows that a large percentage of patients report improved sleep quality after endoscopic sinus surgery.
DOI: 10.6084/m9.figshare.11391285.v1
title: Sleep quality assessment in chronic rhinosinusitis patients submitted to endoscopic sinus surgery: a meta-analysis

description: Abstract Introduction: Chronic rhinosinusitis can lead to poor sleep quality in affected individuals. Endoscopic nasal surgery has been indicated for patients with chronic rhinosinusitis, resulting in improved quality of life, but it is still unknown if there is a similar improvement in sleep quality after the surgical procedure. Objective: To estimate the sleep quality of patients with chronic rhinosinusitis after undergoing endoscopic sinus surgery. Methods: The literature search was conducted in the indexed databases PubMed, Embase, Lilacs, SciELO, Google Scholar, Web of Science, Scopus, Database of Thesis and Dissertations of CAPES, Cochrane Library, Clinical Trials and in the grey literature. It included studies that reported the sleep quality of patients with chronic rhinosinusitis after undergoing endoscopic sinus surgery based on questionnaires assessing quality of life. Two researchers independently conducted the study selection and extraction. The random effects model was chosen to conduct the meta-analysis that was performed using the statistical package STATA, version 11. Results: Overall, 4 studies and 509 subjects were included in the systematic review. Improved sleep quality was observed in 90% of the patients. There was an improvement (on average, from 57% to 67%) in each of the five symptoms related to sleep quality. The results of the meta-analysis revealed high heterogeneity. Conclusions: This review shows that a large percentage of patients report improved sleep quality after endoscopic sinus surgery.
DOI: 10.6073/pasta/1219a5b1967e70fd5ff258aa62c436ff
title: McMurdo Dry Valleys site, station East Lake Bonney, study of sulfate in lake water in units of milligramsPerLiter on a yearly timescale
DOI: 10.6073/pasta/1c84ba83b759a9168e0c27efa98433d5
title: Soil Total Carbon and Total Nitrogen on the Main Cropping System  Experiment (1989 to 2001)
DOI: 10.6073/pasta/1facfbf843b02b7ccc00aefd184d20f6
title: Kellogg Biological Station site, station Treatment SF, old field successional community, never tilled, study of aboveground net primary productivity of Prunus serotina in units of gramsPerMeterSquaredPerYear on a yearly timescale
DOI: 10.6073/pasta/22dfb6e2c9881383f230044f9259fbe3
title: McMurdo Dry Valleys site, station East Lake Bonney, study of nitrogen from ammonium in lake water in units of milligramsPerLiter on a yearly timescale
DOI: 10.6073/pasta/34359fc536b3c3f3ab1fd2af72ad71dd
title: McMurdo Dry Valleys site, station East Lake Bonney, study of ammonium in lake water in units of milligramsPerLiter on a yearly timescale
DOI: 10.6073/pasta/57250016de73dbcd57efcc97bf685785
title: McMurdo Dry Valleys site, station East Lake Bonney, study of chloride in lake water in units of milligramsPerLiter on a yearly timescale
DOI: 10.6073/pasta/699a228c21e4208565562aa94ff79417
title: McMurdo Dry Valleys site, station East Lake Bonney, study of primary production, measured as carbon in units of gramsPerMeterSquaredPerYear on a yearly timescale
DOI: 10.6073/pasta/8590a963583519753cb67c608268ddb8
title: Kellogg Biological Station site, station Treatment SF, old field successional community, never tilled, study of aboveground net primary productivity of Potentilla simplex in units of gramsPerMeterSquaredPerYear on a yearly timescale
DOI: 10.6073/pasta/9c28e3d2abb827edb011b2bffc12cd8e
title: McMurdo Dry Valleys site, station West Lake Bonney, study of primary production, measured as carbon in units of gramsPerMeterSquaredPerYear on a yearly timescale
DOI: 10.6073/pasta/a3e05253005d0a5a64fe533d22ddafaa
title: Agronomic Yields in Row Crop Agriculture (1989 to 2011)
DOI: 10.6073/pasta/bdd5e24270b0140c40968b844bcd045d
title: Kellogg Biological Station site, station Treatment SF, old field successional community, never tilled, study of aboveground net primary productivity of Potentilla recta in units of gramsPerMeterSquaredPerYear on a yearly timescale
DOI: 10.6073/pasta/c59abe8110d40ff5d81b2bdd7ab981d7
title: Kellogg Biological Station site, station Treatment SF, old field successional community, never tilled, study of aboveground net primary productivity of Polygonum convolvulus in units of gramsPerMeterSquaredPerYear on a yearly timescale
DOI: 10.6073/pasta/ca1aeee84e98071ffc94d5eb237d8089
title: Comprehensive Soil Water Chemistry of the Main Cropping System  Experiment (1999 to 2003)
DOI: 10.6073/pasta/dd6ac415bdb8fa12a2e2b45d4e782cad
title: McMurdo Dry Valleys site, station East Lake Bonney, study of sulfur from sulfate in lake water in units of milligramsPerLiter on a yearly timescale
DOI: 10.6073/pasta/e1b63ef6ecac329c09cc435cc029440f
title: Kellogg Biological Station site, station Treatment SF, old field successional community, never tilled, study of aboveground net primary productivity of Poa in units of gramsPerMeterSquaredPerYear on a yearly timescale
DOI: 10.6073/pasta/e4339c44ab66a1efdb67db8194f919be
title: Kellogg Biological Station site, station Treatment SF, old field successional community, never tilled, study of aboveground net primary productivity of Phleum pratense in units of gramsPerMeterSquaredPerYear on a yearly timescale
DOI: 10.6073/pasta/e7ef3ec4175342095bece334433c0d93
title: McMurdo Dry Valleys site, station East Lake Bonney, study of nitrogen from nitrate in lake water in units of milligramsPerLiter on a yearly timescale
DOI: 10.6073/pasta/f33844715477b8d0739d5dafc6a32a60
title: Kellogg Biological Station site, station Treatment SF, old field successional community, never tilled, study of aboveground net primary productivity of Poa compressa in units of gramsPerMeterSquaredPerYear on a yearly timescale
DOI: 10.6073/pasta/f6397c8e176787535e0c608c00cea53c
title: McMurdo Dry Valleys site, station East Lake Bonney, study of nitrate in lake water in units of milligramsPerLiter on a yearly timescale
DOI: 10.6073/pasta/f7c94131ffb7b5ceeb817aeafd26128f
title: National Weather Service Daily Observations at Kalamazoo Hospital  (1887 to 1987)
DOI: 10.6073/pasta/fbfce04752c3411d323d8351047b7046
title: Kellogg Biological Station site, station Treatment SF, old field successional community, never tilled, study of aboveground net primary productivity of Plantago lanceolata in units of gramsPerMeterSquaredPerYear on a yearly timescale
DOI: 10.6073/pasta/fec7d4ed372510c812109da61c5036de
title: Kellogg Biological Station site, station Treatment SF, old field successional community, never tilled, study of aboveground net primary productivity of Poa pratensis in units of gramsPerMeterSquaredPerYear on a yearly timescale
DOI: 10.6073/pasta/0241db30c2f57e076fd8e8d32e0ffd7a
title: McMurdo Dry Valleys site, station Lake Hoare, study of wind speed (mean) in units of metersPerSecond on a yearly timescale
DOI: 10.6073/pasta/24f4d8d48d173a8e7bb9f3a7b593cd79
title: McMurdo Dry Valleys site, station Lake Hoare, study of solar radiation (mean) in units of megajoulesPerSquareMeter on a monthly timescale
DOI: 10.6073/pasta/58a4c23dbdd38c374a88e85c39cf91de
title: Kellogg Biological Station site, station Treatment SF, old field successional community, never tilled, study of aboveground net primary productivity of Prunella vulgaris in units of gramsPerMeterSquaredPerYear on a yearly timescale
DOI: 10.6073/pasta/5b3ff2eb82a78950a2721b6d0d00d961
title: Kellogg Biological Station site, station Treatment SF, old field successional community, never tilled, study of aboveground net primary productivity of Quercus in units of gramsPerMeterSquaredPerYear on a yearly timescale
DOI: 10.6073/pasta/606fc47efb671d0484961b5faa52719c
title: McMurdo Dry Valleys site, station Lake Hoare, study of wind speed (mean) in units of metersPerSecond on a monthly timescale
DOI: 10.6073/pasta/6a8f46a7022296a7e262d55e6030fed9
title: McMurdo Dry Valleys site, station Lake Bonney, study of precipitation in units of centimeter on a yearly timescale
DOI: 10.6073/pasta/76cdd0ae94fc732413a3248099e723ef
title: McMurdo Dry Valleys site, station Nematode research site, study of animal density of Scottnema lindsayae in units of numberPerKilogramDrySoil on a yearly timescale
DOI: 10.6073/pasta/78e5fba59275f0a6c2898bb0ccdba837
title: Kellogg Biological Station site, station Treatment SF, old field successional community, never tilled, study of aboveground net primary productivity of Prunus virginiana in units of gramsPerMeterSquaredPerYear on a yearly timescale
DOI: 10.6073/pasta/866cf96c5222c8cc5b28ab546efd61b2
title: Kellogg Biological Station site, station Treatment SF, old field successional community, never tilled, study of aboveground net primary productivity of Rosa in units of gramsPerMeterSquaredPerYear on a yearly timescale
DOI: 10.6073/pasta/8e2dd45772059a97633c708383ed515a
title: McMurdo Dry Valleys site, station Nematode research site, study of animal density of nematodes in units of numberPerKilogramDrySoil on a yearly timescale
DOI: 10.6073/pasta/95ac6e8d07d37ab1e044bcfdf040e053
title: McMurdo Dry Valleys site, station Lake Bonney, study of precipitation in units of centimeter on a monthly timescale
DOI: 10.6073/pasta/a66fab4f0ebd80f32d6829d515146939
title: Kellogg Biological Station site, station Treatment SF, old field successional community, never tilled, study of aboveground net primary productivity of Prunus in units of gramsPerMeterSquaredPerYear on a yearly timescale
DOI: 10.6073/pasta/b70d68fa4097f3959bdb9c775200d2e3
title: McMurdo Dry Valleys site, station Lake Hoare, study of solar radiation (mean) in units of megajoulesPerSquareMeter on a yearly timescale
DOI: 10.6073/pasta/cf4a12c906b4adaeb3b835a60ee28d6c
title: Kellogg Biological Station site, station Treatment SF, old field successional community, never tilled, study of aboveground net primary productivity of Robinia pseudoacacia in units of gramsPerMeterSquaredPerYear on a yearly timescale
DOI: 10.6073/pasta/db68a308e19250e3c4aebc1c3b08ba56
title: McMurdo Dry Valleys site, station Nematode research site, study of animal density of Eudorylaimus in units of numberPerKilogramDrySoil on a yearly timescale
DOI: 10.6073/pasta/e3fe437c2a716bea4f7b2e567151ddb6
title: Kellogg Biological Station site, station Treatment SF, old field successional community, never tilled, study of aboveground net primary productivity of Rhamnus cathartica in units of gramsPerMeterSquaredPerYear on a yearly timescale