cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.1409398.v233
title: ABO phenotype protected reproduction as it is based on fucosylations.

description: The molecular biological relationship between human fertility and ABO(H) blood group phenotype formation becomes evident with the rare (Oh) or <i>Bombay</i> blood type, which based on the history of his own family, Charles Darwin would have interpreted as resulting from reduced fertility in consanguinities. In its native form, the <i>Bombay</i> type occurs in individuals with an extremely rare genotype (h/h;se/se), by which the fucosyltransferases FUT1 and FUT2 are not produced due to point mutations. These enzymes, encoded on chromosome 19, are epistatically connected with the A and B allelic glycotransferase functions encoded on chromosome 9, while the fucosyl residues provide the functional-structural basis for the formation of any ABO(H) phenotype on the cell surface or in secretions and plasma proteins. Immunoglobulins are also heavily fucosylated, and via developmental variation of the positions between the cell surfaces and the heavy chains of immunoglobulins, fucosyl residues appear to augment or reduce antibody-mediated cellular cytotoxicity involving physiological anti-self-reactivity; moreover, by regulating the assembly and intracellular signaling of precursor B cell receptors, the core fucosylation of immunoglobulin heavy chains represents a key mechanism in clonal selection. In fact, the seminal plasma of leucospermic infertile men has been reported to exert high levels of poorly core-fucosylated IgG. Consequently, in <i>Bombay </i>type individuals, the non-somatic glycosylation processes of embryogenic stem cell-to-germ cell transformation, which involve the modification and <i>O</i>-fucosylation of epidermal growth factor (EGF), are most likely exposed to metabolic competition with multiple glycosidic sites of poorly fucosylated, glycan-depleted immunoglobulins that might promote increased anti-self-reactive cytotoxicity.
DOI: 10.6084/m9.figshare.1399152
title: SNP/indel/CNV/Deletion dataset header order plus NCBI SRA

description: Header of previous released SNP/indel/CNV/Deletion dataset.
DOI: 10.6084/m9.figshare.1399154.v2
title: Associations between prenatal physical activity, birth weight, and DNA methylation at genomically imprinted domains in a multiethnic newborn cohort

description: Birth weight is a commonly used indicator of the fetal environment and a predictor of future health outcomes. While the etiology of birth weight extremes is likely multifactorial, epidemiologic data suggest that prenatal physical activity (PA) may play an important role. The mechanisms underlying this association remain unresolved, although epigenetics has been proposed. This study aimed to estimate associations between prenatal PA, birth weight, and newborn DNA methylation levels at differentially methylated regions (DMRs) regulating 4 imprinted genes known to be important in fetal development. Study participants (N = 1281) were enrolled as part of the Newborn Epigenetics Study. Prenatal PA was ascertained using the Pregnancy Physical Activity Questionnaire, and birth weight data obtained from hospital records. Among 484 term mother-infant pairs, imprinted gene methylation levels were measured at DMRs using bisulfite pyrosequencing. Generalized linear and logistic regression models were used to estimate associations. After adjusting for preterm birth and race/ethnicity, we found that infants born to mothers in the highest quartile of total non-sedentary time had lower birth weight compared to infants of mothers in the lowest quartile (β = −81.16, SE = 42.02, <i>P</i> = 0.05). These associations appeared strongest among male infants (β = −125.40, SE = 58.10, <i>P</i> = 0.03). Methylation at the <i>PLAGL1</i> DMR was related to total non-sedentary time (<i>P</i> &lt; 0.05). Our findings confirm that prenatal PA is associated with reduced birth weight, and is the first study to support a role for imprinted gene plasticity in these associations. Larger studies are required.
DOI: 10.6084/m9.figshare.1399157.v2
title: A dynein independent role of Tctex-1 at the kinetochore

description: Dynein light chains are accessory subunits of the cytoplasmic dynein complex, a minus-end directed microtubule motor. Here, we demonstrate that the dynein light chain Tctex-1 associates with unattached kinetochores and is essential for accurate chromosome segregation. Tctex-1 knockdown in cells does not affect the localization and function of dynein at the kinetochore, but produces a prolonged mitotic arrest with a few misaligned chromosomes, which are subsequently missegregated during anaphase. This function is independent of Tctex-1's association with dynein. The kinetochore localization of Tctex-1 is independent of the ZW10-dynein pathway, but requires the Ndc80 complex. Thus, our findings reveal a dynein independent role of Tctex-1 at the kinetochore to enhance the stability of kinetochore-microtubule attachment.
DOI: 10.6084/m9.figshare.1399154.v4
title: Associations between prenatal physical activity, birth weight, and DNA methylation at genomically imprinted domains in a multiethnic newborn cohort

description: Birth weight is a commonly used indicator of the fetal environment and a predictor of future health outcomes. While the etiology of birth weight extremes is likely multifactorial, epidemiologic data suggest that prenatal physical activity (PA) may play an important role. The mechanisms underlying this association remain unresolved, although epigenetics has been proposed. This study aimed to estimate associations between prenatal PA, birth weight, and newborn DNA methylation levels at differentially methylated regions (DMRs) regulating 4 imprinted genes known to be important in fetal development. Study participants (N = 1281) were enrolled as part of the Newborn Epigenetics Study. Prenatal PA was ascertained using the Pregnancy Physical Activity Questionnaire, and birth weight data obtained from hospital records. Among 484 term mother-infant pairs, imprinted gene methylation levels were measured at DMRs using bisulfite pyrosequencing. Generalized linear and logistic regression models were used to estimate associations. After adjusting for preterm birth and race/ethnicity, we found that infants born to mothers in the highest quartile of total non-sedentary time had lower birth weight compared to infants of mothers in the lowest quartile (β = −81.16, SE = 42.02, <i>P</i> = 0.05). These associations appeared strongest among male infants (β = −125.40, SE = 58.10, <i>P</i> = 0.03). Methylation at the <i>PLAGL1</i> DMR was related to total non-sedentary time (<i>P</i> &lt; 0.05). Our findings confirm that prenatal PA is associated with reduced birth weight, and is the first study to support a role for imprinted gene plasticity in these associations. Larger studies are required.
DOI: 10.6084/m9.figshare.1399154.v3
title: Associations between prenatal physical activity, birth weight, and DNA methylation at genomically imprinted domains in a multiethnic newborn cohort

description: Birth weight is a commonly used indicator of the fetal environment and a predictor of future health outcomes. While the etiology of birth weight extremes is likely multifactorial, epidemiologic data suggest that prenatal physical activity (PA) may play an important role. The mechanisms underlying this association remain unresolved, although epigenetics has been proposed. This study aimed to estimate associations between prenatal PA, birth weight, and newborn DNA methylation levels at differentially methylated regions (DMRs) regulating 4 imprinted genes known to be important in fetal development. Study participants (N = 1281) were enrolled as part of the Newborn Epigenetics Study. Prenatal PA was ascertained using the Pregnancy Physical Activity Questionnaire, and birth weight data obtained from hospital records. Among 484 term mother-infant pairs, imprinted gene methylation levels were measured at DMRs using bisulfite pyrosequencing. Generalized linear and logistic regression models were used to estimate associations. After adjusting for preterm birth and race/ethnicity, we found that infants born to mothers in the highest quartile of total non-sedentary time had lower birth weight compared to infants of mothers in the lowest quartile (β = −81.16, SE = 42.02, <i>P</i> = 0.05). These associations appeared strongest among male infants (β = −125.40, SE = 58.10, <i>P</i> = 0.03). Methylation at the <i>PLAGL1</i> DMR was related to total non-sedentary time (<i>P</i> &lt; 0.05). Our findings confirm that prenatal PA is associated with reduced birth weight, and is the first study to support a role for imprinted gene plasticity in these associations. Larger studies are required.
DOI: 10.6084/m9.figshare.1409398.v234
title: ABO phenotype protected reproduction as it is based on fucosylations.

description: The molecular biological relationship between human fertility and ABO(H) blood group phenotype formation becomes evident with the rare (Oh) or <i>Bombay</i> blood type, which based on the history of his own family, Charles Darwin would have interpreted as resulting from reduced fertility in consanguinities. In its native form, the <i>Bombay</i> type occurs in individuals with an extremely rare genotype (h/h;se/se), by which the fucosyltransferases FUT1 and FUT2 are not produced due to point mutations. These enzymes, encoded on chromosome 19, are epistatically connected with the A and B allelic glycotransferase functions encoded on chromosome 9, while the fucosyl residues provide the functional-structural basis for the formation of any ABO(H) phenotype on the cell surface or in secretions and plasma proteins. Immunoglobulins are also heavily fucosylated, and via developmental variation of the positions between the cell surfaces and the heavy chains of immunoglobulins, fucosyl residues appear to augment or reduce antibody-mediated cellular cytotoxicity involving physiological anti-self-reactivity; moreover, by regulating the assembly and intracellular signaling of precursor B cell receptors, the core fucosylation of immunoglobulin heavy chains represents a key mechanism in clonal selection. In fact, the seminal plasma of leucospermic infertile men has been reported to exert high levels of poorly core-fucosylated IgG. Consequently, in <i>Bombay </i>type individuals, the non-somatic glycosylation processes of embryogenic stem cell-to-germ cell transformation, which involve the modification and <i>O</i>-fucosylation of epidermal growth factor (EGF), are most likely exposed to metabolic competition with multiple glycosidic sites of poorly fucosylated, glycan-depleted immunoglobulins that might promote increased anti-self-reactive cytotoxicity.
DOI: 10.6084/m9.figshare.1409398.v235
title: ABO phenotype protected reproduction as it is based on fucosylations.

description: The molecular biological relationship between human fertility and ABO(H) blood group phenotype formation becomes evident with the rare (Oh) or <i>Bombay</i> blood type, which based on the history of his own family, Charles Darwin would have interpreted as resulting from reduced fertility in consanguinities. In its native form, the <i>Bombay</i> type occurs in individuals with an extremely rare genotype (h/h;se/se), by which the fucosyltransferases FUT1 and FUT2 are not produced due to point mutations. These enzymes, encoded on chromosome 19, are epistatically connected with the A and B allelic glycotransferase functions encoded on chromosome 9, while the fucosyl residues provide the functional-structural basis for the formation of any ABO(H) phenotype on the cell surface or in secretions and plasma proteins. Immunoglobulins are also heavily fucosylated, and via developmental variation of the positions between the cell surfaces and the heavy chains of immunoglobulins, fucosyl residues appear to augment or reduce antibody-mediated cellular cytotoxicity involving physiological anti-self-reactivity; moreover, by regulating the assembly and intracellular signaling of precursor B cell receptors, the core fucosylation of immunoglobulin heavy chains represents a key mechanism in clonal selection. In fact, the seminal plasma of leucospermic infertile men has been reported to exert high levels of poorly core-fucosylated IgG. Consequently, in <i>Bombay </i>type individuals, the non-somatic glycosylation processes of embryogenic stem cell-to-germ cell transformation, which involve the modification and <i>O</i>-fucosylation of epidermal growth factor (EGF), are most likely exposed to metabolic competition with multiple glycosidic sites of poorly fucosylated, glycan-depleted immunoglobulins that might promote increased anti-self-reactive cytotoxicity.
DOI: 10.6084/m9.figshare.1399152.v1
title: SNP/indel/CNV/Deletion dataset header order

description: Header of previous released SNP/indel/CNV/Deletion dataset.
DOI: 10.6084/m9.figshare.1409398.v236
title: ABO phenotype protected reproduction as it is based on fucosylations.

description: The molecular biological relationship between human fertility and ABO(H) blood group phenotype formation becomes evident with the rare (Oh) or <i>Bombay</i> blood type, which based on the history of his own family, Charles Darwin would have interpreted as resulting from reduced fertility in consanguinities. In its native form, the <i>Bombay</i> type occurs in individuals with an extremely rare genotype (h/h;se/se), by which the fucosyltransferases FUT1 and FUT2 are not produced due to point mutations. These enzymes, encoded on chromosome 19, are epistatically connected with the A and B allelic glycotransferase functions encoded on chromosome 9, while the fucosyl residues provide the functional-structural basis for the formation of any ABO(H) phenotype on the cell surface or in secretions and plasma proteins. Immunoglobulins are also heavily fucosylated, and via developmental variation of the positions between the cell surfaces and the heavy chains of immunoglobulins, fucosyl residues appear to augment or reduce antibody-mediated cellular cytotoxicity involving physiological anti-self-reactivity; moreover, by regulating the assembly and intracellular signaling of precursor B cell receptors, the core fucosylation of immunoglobulin heavy chains represents a key mechanism in clonal selection. In fact, the seminal plasma of leucospermic infertile men has been reported to exert high levels of poorly core-fucosylated IgG. Consequently, in <i>Bombay </i>type individuals, the non-somatic glycosylation processes of embryogenic stem cell-to-germ cell transformation, which involve the modification and <i>O</i>-fucosylation of epidermal growth factor (EGF), are most likely exposed to metabolic competition with multiple glycosidic sites of poorly fucosylated, glycan-depleted immunoglobulins that might promote increased anti-self-reactive cytotoxicity.
DOI: 10.6084/m9.figshare.1399131
title: Extended Tables (Tags, Artists, Topic Composition)

description: A PDF file with tables providing information on the Topics from the paper "Evolution of Popular Music: USA 1960–2010". 1 Top tags per topic — for each Topic, this table provides the Last.fm tags that had the highest (and lowest) average saturation of that Topic. 2 Top tags per artist — for each Topic, this table provides the artists that had the highest (and lowest) average saturation of that Topic. 3 Most Likely timbres and chord changes — every Topic is a mixture of "musical words": chord changes (in the case of H-Topics) or timbre clusters (in the case of T-Topics). This table provides the top "words" for every topic.
DOI: 10.6084/m9.figshare.1399152.v3
title: SNP/indel/CNV/Deletion dataset header order plus NCBI SRA

description: Header of previous released SNP/indel/CNV/Deletion dataset.
DOI: 10.6084/m9.figshare.1399152.v2
title: SNP/indel/CNV/Deletion dataset header order

description: Header of previous released SNP/indel/CNV/Deletion dataset.
DOI: 10.6084/m9.figshare.1409398.v237
title: ABO phenotype protected reproduction as it is based on fucosylations.

description: The molecular biological relationship between human fertility and ABO(H) blood group phenotype formation becomes evident with the rare (Oh) or <i>Bombay</i> blood type, which, based on the history of his own family, Charles Darwin would have interpreted as resulting from reduced fertility in consanguinities. In its native form, the <i>Bombay</i> type occurs in individuals with an extremely rare genotype (h/h;se/se), by which the fucosyltransferases FUT1 and FUT2 are not produced due to point mutations. These enzymes, encoded on chromosome 19, are epistatically connected with the A and B allelic glycotransferase functions encoded on chromosome 9, while the fucosyl residues provide the functional-structural basis for the formation of any ABO(H) phenotype on the cell surface or in secretions and plasma proteins. Immunoglobulins are also heavily fucosylated, and via developmental variation in the positions between the cell surfaces and the heavy chains of immunoglobulins, fucosyl residues appear to augment or reduce antibody-mediated cellular cytotoxicity involving physiological anti-self-reactivity; moreover, by regulating the assembly and intracellular signaling of precursor B cell receptors, the core fucosylation of immunoglobulin heavy chains represents a key mechanism in clonal selection. In fact, the seminal plasma of leukospermic infertile men has been reported to exert high levels of poorly core-fucosylated IgG. Consequently, in <i>Bombay </i>type individuals, non-somatic glycosylation processes of embryogenic stem cell-to-germ cell transformation, which involve the modification and <i>O</i>-fucosylation of epidermal growth factor (EGF), are most likely exposed to metabolic competition with multiple glycosidic sites of poorly fucosylated, glycan-depleted immunoglobulins promoting anti-self-reactive cellular cytotoxicity in male gamete performance.
DOI: 10.6084/m9.figshare.1399102
title: Raw Data (Anonymised)

description: The data pertaines to the article "The Intra- and Inter-Rater Reliability of an Instrumented Spasticity Assessment in Children with Cerebral Palsy". The values were used to calculate the various components of reliability.
DOI: 10.6084/m9.figshare.1409398.v238
title: ABO phenotype protected reproduction as it is based on fucosylations.

description: The molecular biological relationship between human fertility and ABO(H) blood group phenotype formation becomes evident with the rare (Oh) or <i>Bombay</i> blood type, which, based on the history of his own family, Charles Darwin would have interpreted as resulting from reduced fertility in consanguinities. In its native form, the <i>Bombay</i> type occurs in individuals with an extremely rare genotype (h/h;se/se), by which the fucosyltransferases FUT1 and FUT2 are not produced due to point mutations. These enzymes, encoded on chromosome 19, are epistatically connected with the A and B allelic glycotransferase functions encoded on chromosome 9, while the fucosyl residues provide the functional-structural basis for the formation of any ABO(H) phenotype on the cell surface or in secretions and plasma proteins. Immunoglobulins are also heavily fucosylated, and via developmental variation in the positions between the cell surfaces and the heavy chains of immunoglobulins, fucosyl residues appear to augment or reduce antibody-mediated cellular cytotoxicity involving physiological anti-self-reactivity; moreover, by regulating the assembly and intracellular signaling of precursor B cell receptors, the core fucosylation of immunoglobulin heavy chains represents a key mechanism in clonal selection. In fact, the seminal plasma of leukospermic infertile men has been reported to exert high levels of poorly core-fucosylated IgG. Consequently, in <i>Bombay </i>type individuals, non-somatic glycosylation processes of embryogenic stem cell-to-germ cell transformation, which involve the modification and <i>O</i>-fucosylation of epidermal growth factor (EGF), are most likely exposed to metabolic competition with multiple glycosidic sites of poorly fucosylated, glycan-depleted immunoglobulins promoting anti-self-reactive cellular cytotoxicity in male gamete performance.
DOI: 10.6084/m9.figshare.1399111
title: Effects of solar radiation on pigmentation and induction of a mycosporine-like amino acid in two cyanobacteria, <i>Anabaena</i> sp. and <i>Nostoc</i> sp. ISC26

description: ABSTRACTThe effect of filtered natural solar radiation, including photosynthetically active radiation (PAR) and PAR+ultraviolet radiation (UVR), on pigmentation and synthesis of a UV absorbing ‘mycosporine-like amino acid’ (MAA) in two filamentous and heterocystous cyanobacteria, <i>Anabaena</i> sp. and <i>Nostoc</i> sp. ISC26 was studied over 3 days. In <i>Anabaena</i> sp. and <i>Nostoc</i> sp. ISC26, chlorophyll <i>a</i> (chl <i>a</i>) content decreased after 72 h to 5.45 ± 0.09 and 7.01 ± 0.54 μg mg<sup>−</sup><sup>1</sup> DW respectively under PAR treatments; and to 4.33 ± 0.22, 6.12 ± 0.04 μg mg<sup>−</sup><sup>1</sup> DW in PAR+UV treatments, as did carotenoids (Car) (2.68 ± 0.01, 2.93 ± 0.01 μg mg<sup>−</sup><sup>1</sup> DW) (PAR), (2.53 ± 0.01, 2.57 ± 0.05 μg mg<sup>−</sup><sup>1</sup> DW) (PAR+UV). A considerable increase was observed in the carotenoid:chlorophyll <i>a</i> (Car/Chl <i>a</i>) ratio as a result of carotenoid accumulation in the first 24 h and reduction of chlorophyll in the following days. A single MAA was isolated, purified by high performance liquid chromatography (HPLC) and identified as shinorine. Shinorine concentration increased significantly during 72 h specifically under PAR+UV (1270.8 ± 50.42, 2208.09 ± 73.04 nmol g<sup>−</sup><sup>1</sup> DW) in <i>Anabaena</i> sp. and <i>Nostoc</i> sp. ISC26, respectively, indicating an adaptation strategy of cyanobacteria against harmful solar short wavelength radiation especially in natural habitats.
DOI: 10.6084/m9.figshare.1399111.v2
title: Effects of solar radiation on pigmentation and induction of a mycosporine-like amino acid in two cyanobacteria, <i>Anabaena</i> sp. and <i>Nostoc</i> sp. ISC26

description: ABSTRACTThe effect of filtered natural solar radiation, including photosynthetically active radiation (PAR) and PAR+ultraviolet radiation (UVR), on pigmentation and synthesis of a UV absorbing ‘mycosporine-like amino acid’ (MAA) in two filamentous and heterocystous cyanobacteria, <i>Anabaena</i> sp. and <i>Nostoc</i> sp. ISC26 was studied over 3 days. In <i>Anabaena</i> sp. and <i>Nostoc</i> sp. ISC26, chlorophyll <i>a</i> (chl <i>a</i>) content decreased after 72 h to 5.45 ± 0.09 and 7.01 ± 0.54 μg mg<sup>−</sup><sup>1</sup> DW respectively under PAR treatments; and to 4.33 ± 0.22, 6.12 ± 0.04 μg mg<sup>−</sup><sup>1</sup> DW in PAR+UV treatments, as did carotenoids (Car) (2.68 ± 0.01, 2.93 ± 0.01 μg mg<sup>−</sup><sup>1</sup> DW) (PAR), (2.53 ± 0.01, 2.57 ± 0.05 μg mg<sup>−</sup><sup>1</sup> DW) (PAR+UV). A considerable increase was observed in the carotenoid:chlorophyll <i>a</i> (Car/Chl <i>a</i>) ratio as a result of carotenoid accumulation in the first 24 h and reduction of chlorophyll in the following days. A single MAA was isolated, purified by high performance liquid chromatography (HPLC) and identified as shinorine. Shinorine concentration increased significantly during 72 h specifically under PAR+UV (1270.8 ± 50.42, 2208.09 ± 73.04 nmol g<sup>−</sup><sup>1</sup> DW) in <i>Anabaena</i> sp. and <i>Nostoc</i> sp. ISC26, respectively, indicating an adaptation strategy of cyanobacteria against harmful solar short wavelength radiation especially in natural habitats.