cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.28295516
title: Formulation and clinical evaluation of hyaluronic acid nanogel in treatment of tear trough: nano-flipping from injectable fillers to topical nanofillers

description: Tear trough deformity (TTD) is a significant cosmetic concern, with current treatments relying primarily on invasive injectable fillers, which are costly and carry risks of complications. Despite the widespread use of hyaluronic acid (HA) in cosmetic applications, its poor dermal permeation has limited the development of effective topical fillers for TTD. This study aim to develop and evaluate a novel hyaluronic acid nanogel (nanofiller, NF) as a non-invasive topical filler for TTD. The hyaluronic acid NF was formulated and characterized for size, zeta potential, and skin permeation using the Franz diffusion method. The nanofiller demonstrated a particle size of 213.28 ± 4.15 nm and a zeta potential of −22.1 ± 1.07 mV, with a tenfold superior permeation compared to conventional HA gel. Thirty adult female patients aged 21–50 years with TTD were enrolled in a clinical trial and randomly assigned to receive either the NF or a conventional HA gel (control). Participants were randomly assigned to receive either the NF or a conventional HA gel (control). Clinical evaluation included subjective assessments and objective photomorphometric measurements of TTD parameters such as skin roughness (fine lines), indentation index, mean density, and percentage of the affected area. The NF group showed a significant improvement in TTD parameters, including up to a 40-fold reduction in skin roughness and indentation index, with 100% patient satisfaction and no adverse effects, compared to the control group. "To conclude; this study demonstrates the efficacy and safety of the HA nanofiller as the first effective topical treatment for TTD, offering a non-invasive alternative to injectable fillers.
DOI: 10.6084/m9.figshare.28295516.v2
title: Formulation and clinical evaluation of hyaluronic acid nanogel in treatment of tear trough: nano-flipping from injectable fillers to topical nanofillers

description: Tear trough deformity (TTD) is a significant cosmetic concern, with current treatments relying primarily on invasive injectable fillers, which are costly and carry risks of complications. Despite the widespread use of hyaluronic acid (HA) in cosmetic applications, its poor dermal permeation has limited the development of effective topical fillers for TTD. This study aim to develop and evaluate a novel hyaluronic acid nanogel (nanofiller, NF) as a non-invasive topical filler for TTD. The hyaluronic acid NF was formulated and characterized for size, zeta potential, and skin permeation using the Franz diffusion method. The nanofiller demonstrated a particle size of 213.28 ± 4.15 nm and a zeta potential of −22.1 ± 1.07 mV, with a tenfold superior permeation compared to conventional HA gel. Thirty adult female patients aged 21–50 years with TTD were enrolled in a clinical trial and randomly assigned to receive either the NF or a conventional HA gel (control). Participants were randomly assigned to receive either the NF or a conventional HA gel (control). Clinical evaluation included subjective assessments and objective photomorphometric measurements of TTD parameters such as skin roughness (fine lines), indentation index, mean density, and percentage of the affected area. The NF group showed a significant improvement in TTD parameters, including up to a 40-fold reduction in skin roughness and indentation index, with 100% patient satisfaction and no adverse effects, compared to the control group. "To conclude; this study demonstrates the efficacy and safety of the HA nanofiller as the first effective topical treatment for TTD, offering a non-invasive alternative to injectable fillers.
DOI: 10.6084/m9.figshare.28295516.v1
title: Formulation and clinical evaluation of hyaluronic acid nanogel in treatment of tear trough: Nano-flipping from injectable fillers to topical nanofillers

description: Tear trough deformity (TTD) is a significant cosmetic concern, with current treatments relying primarily on invasive injectable fillers, which are costly and carry risks of complications. Despite the widespread use of hyaluronic acid (HA) in cosmetic applications, its poor dermal permeation has limited the development of effective topical fillers for TTD. This study aim to develop and evaluate a novel hyaluronic acid nanogel (nanofiller, NF) as a non-invasive topical filler for TTD. The hyaluronic acid NF was formulated and characterized for size, zeta potential, and skin permeation using the Franz diffusion method. The nanofiller demonstrated a particle size of 213.28 ± 4.15 nm and a zeta potential of -22.1 ± 1.07 mV, with a tenfold superior permeation compared to conventional HA gel. Thirty adult female patients aged 21–50 years with TTD were enrolled in a clinical trial and randomly assigned to receive either the NF or a conventional HA gel (control). Participants were randomly assigned to receive either the NF or a conventional HA gel (control). Clinical evaluation included subjective assessments and objective photomorphometric measurements of TTD parameters such as skin roughness (fine lines), indentation index, mean density, and percentage of the affected area. The NF group showed a significant improvement in TTD parameters, including up to a 40-fold reduction in skin roughness and indentation index, with 100% patient satisfaction and no adverse effects, compared to the control group.”To conclude; this study demonstrates the efficacy and safety of the HA nanofiller as the first effective topical treatment for TTD, offering a non-invasive alternative to injectable fillers.
DOI: 10.6084/m9.figshare.28335301
title: Long-acting release of fluocinolone acetonide microspheres using electrospray technology for noninfectious uveitis therapy

description: Intravitreous long-acting drug delivery system offers an excellent alternative to multiple injections for the treatment of noninfectious uveitis (NIU). However, the adverse effects of non-biodegradable intravitreal implants of fluocinolone acetonide (FA), such as postoperative hypotony and secondary injury during removal of the implant matrix, are frequent occurrence to affect patient’s compliance. Herein, biodegradable poly (lactic-co-glycolic acid) (PLGA)-based microspheres (MS) containing fluocinolone acetonide (FA@MS) were prepared using an optimized electrospray technology with a voltage of 10.07 kV and the receiving distance of 9.87 cm. The obtained FA@MS with the average particle size of 2.25 μm possessed the high encapsulation efficiency (94.85%) and drug content (9.48%). <i>In vitro</i> release demonstrated that FA@MS exhibited sustained release for 30 days, and the release characteristic of FA@MS conformed to the Weibull model. <i>In vivo</i> study in a rabbit NIU model indicated that FA@MS continuously released the drug for at least 28 days in vitreum and progressively decreased inflammation of NIU. Furthermore, the intraocular pressure of rabbits treated with blank MS and FA@MS remained the normal level for 28 days, which demonstrated the favorable biosafety of FA@MS. In conclusion, long-acting release of FA@MS provides a promising formulation for NIU treatment.
HIGHLIGHTSA biodegradable FA@MS was prepared using the modified electrospray technology for intravitreal administration.FA@MS exhibited the sustained release characteristics for 30 days in the medium of PBS (pH 7.4) with 0.2% Tween 80.The pharmacodynamics indicated that FA@MS could be continuously released for at least 28 days in vitreum to treat NIU. A biodegradable FA@MS was prepared using the modified electrospray technology for intravitreal administration. FA@MS exhibited the sustained release characteristics for 30 days in the medium of PBS (pH 7.4) with 0.2% Tween 80. The pharmacodynamics indicated that FA@MS could be continuously released for at least 28 days in vitreum to treat NIU.
DOI: 10.6084/m9.figshare.28335301.v2
title: Long-acting release of fluocinolone acetonide microspheres using electrospray technology for noninfectious uveitis therapy

description: Intravitreous long-acting drug delivery system offers an excellent alternative to multiple injections for the treatment of noninfectious uveitis (NIU). However, the adverse effects of non-biodegradable intravitreal implants of fluocinolone acetonide (FA), such as postoperative hypotony and secondary injury during removal of the implant matrix, are frequent occurrence to affect patient’s compliance. Herein, biodegradable poly (lactic-co-glycolic acid) (PLGA)-based microspheres (MS) containing fluocinolone acetonide (FA@MS) were prepared using an optimized electrospray technology with a voltage of 10.07 kV and the receiving distance of 9.87 cm. The obtained FA@MS with the average particle size of 2.25 μm possessed the high encapsulation efficiency (94.85%) and drug content (9.48%). <i>In vitro</i> release demonstrated that FA@MS exhibited sustained release for 30 days, and the release characteristic of FA@MS conformed to the Weibull model. <i>In vivo</i> study in a rabbit NIU model indicated that FA@MS continuously released the drug for at least 28 days in vitreum and progressively decreased inflammation of NIU. Furthermore, the intraocular pressure of rabbits treated with blank MS and FA@MS remained the normal level for 28 days, which demonstrated the favorable biosafety of FA@MS. In conclusion, long-acting release of FA@MS provides a promising formulation for NIU treatment.
HIGHLIGHTSA biodegradable FA@MS was prepared using the modified electrospray technology for intravitreal administration.FA@MS exhibited the sustained release characteristics for 30 days in the medium of PBS (pH 7.4) with 0.2% Tween 80.The pharmacodynamics indicated that FA@MS could be continuously released for at least 28 days in vitreum to treat NIU. A biodegradable FA@MS was prepared using the modified electrospray technology for intravitreal administration. FA@MS exhibited the sustained release characteristics for 30 days in the medium of PBS (pH 7.4) with 0.2% Tween 80. The pharmacodynamics indicated that FA@MS could be continuously released for at least 28 days in vitreum to treat NIU.
DOI: 10.6084/m9.figshare.28335301.v1
title: Long-Acting Release of Fluocinolone Acetonide Microspheres Using Electrospray Technology for Non-infectious Uveitis Therapy

description: Intravitreous long-acting drug delivery system offers an excellent alternative to multiple injections for the treatment of non-infectious uveitis (NIU). However, the adverse effects of non-biodegradable intravitreal implants of fluocinolone acetonide (FA), such as postoperative hypotony and secondary injury during removal of the implant matrix, are frequent occurrence to affect patient’s complicance. Herein, biodegradable poly (lactic-co-glycolic acid) (PLGA)-based microspheres (MS) containing fluocinolone acetonide (FA@MS) were prepared using an optimized electrospray technology with a voltage of 10.07 kV and the receiving distance of 9.87 cm. The obtained FA@MS with the average particle size of 2.25 μm possessed the high encapsulation efficiency (94.85%) and drug content (9.48%). <i>In</i> vitro release demonstrated that FA@MS exhibited sustained release for 30 days, and the release characteristic of FA@MS conformed to the Weibull model. <i>In vivo</i> study in a rabbit NIU model indicated that FA@MS continuously released the drug for at least 28 days in vitreum and progressively decreased inflammation of NIU. Furthermore, the intraocular pressure of rabbits treated with blank MS and FA@MS remained the normal level for 28 days, which demonstrated the favorable biosafety of FA@MS. In conclusion, long-acting release of FA@MS provides a promising formulation for NIU treatment.
DOI: 10.48511/8ue5eije
title: Lower Apex Creek Hydrometric (LCKAPX01H)

description: This dataset contains hydrometric data for Lower Apex Creek. This site is part of the Columbia Basin Water Monitoring Framework program (CBWMF). The CBWMF is a coordinated monitoring network that tracks how climate change and other impacts are affecting water supply for communities and ecosystems across the Canadian Columbia Basin region. Apex Creek was recommended for monitoring through the 2023 CBWMF Data Gap Analysis of the Lower-Columbia Kootenay Hydrologic Region. It is identified as habitat for fish and species at risk. This stream is a tributary to the Apex Wetlands and Salmo River. Monitoring at this site increases the coverage of the "High elevation, cold forested watersheds with a high snow fraction" (Group LCK 3A) which the 2023 CBWMD Data Gap Analysis of the Lower Columbia-Kootenay Hydrologic Region identified as underrepresented in the pre-existing monitoring network. This Lower station is paired with a Upper station (LCKAPX02H), to understand better understand this watershed's dynamics and hydrologic response to climate impacts.
DOI: 10.15468/dl.pjj8cd
title: Occurrence Download

description: A dataset containing 4481 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Mycetoporus lepidus (Gravenhorst, 1806)",
 "HasGeospatialIssue is false",
 "HasCoordinate is true"
 ]
}

 The dataset includes 4481 records from 136 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0015268-250310093411724/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.vfgmhn
title: Occurrence Download

description: A dataset containing 3148 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Sclerocarya birrea (A.Rich.) Hochst.",
 "HasCoordinate is true",
 "BasisOfRecord is one of (Human Observation, Living Specimen, Occurrence evidence)"
 ]
}

 The dataset includes 3148 records from 45 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0015269-250310093411724/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.zzue2m
title: Occurrence Download

description: A dataset containing 122163 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Mionectes oleagineus (Lichtenstein, 1823)"
 ]
}

 The dataset includes 122163 records from 333 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0015249-250310093411724/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.48511/yrc3t80c
title: Eagle Creek (EAG01)

description: Dataset contains analytical results for Eagle Creek.
DOI: 10.15468/dl.2f255k
title: Occurrence Download

description: A dataset containing 263 species occurrences available in GBIF matching the query:
{
 "and" : [
 "BasisOfRecord is Specimen",
 "OccurrenceStatus is Present",
 "TaxonKey is Theropithecus gelada (Rüppell, 1835)"
 ]
}

 The dataset includes 263 records from 32 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0015270-250310093411724/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.964e2n
title: Occurrence Download

description: A dataset containing 158569 species occurrences available in GBIF matching the query:
{
 "DatasetKey" : [
 "is Academy of Natural Sciences Ichthyology Collection"
 ]
}

 The dataset includes 158569 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0015264-250310093411724/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.cks6ub
title: Occurrence Download

description: A dataset containing 68 species occurrences available in GBIF matching the query:
{
 "and" : [
 "BasisOfRecord is Specimen",
 "Country is Spain",
 "DatasetKey is Herbario COFC de la Universidad de Córdoba: colección general de plantas vasculares",
 "Month is March",
 "OccurrenceStatus is Present",
 "TaxonKey is Senecio vulgaris L."
 ]
}

 The dataset includes 68 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0015272-250310093411724/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.y94rv7
title: Occurrence Download

description: A dataset containing 13400 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is Croatia",
 "TaxonKey is Ardea cinerea Linnaeus, 1758"
 ]
}

 The dataset includes 13400 records from 13 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0015273-250310093411724/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.48511/69t3ris7
title: Sandy Creek (SAN01)

description: Dataset contains analytical results for Eagle Creek.
DOI: 10.5281/zenodo.15046922
title: Sample 3D data for "Simulating wind farm flows at hub height with 2D Reynolds-averaged Navier-Stokes simulations"

description: Some 3D data from "Simulating wind farm flows at hub height with 2D Reynolds-averaged Navier-Stokes simulations"by M. Baungaard, T. Nishino, and M. P. van der Laan (2025). Submitted to Wind Energy Science in March 2025.See readme.txt for more info about the data.
DOI: 10.5281/zenodo.15046923
title: Sample 3D data for "Simulating wind farm flows at hub height with 2D Reynolds-averaged Navier-Stokes simulations"

description: Some 3D data from "Simulating wind farm flows at hub height with 2D Reynolds-averaged Navier-Stokes simulations"by M. Baungaard, T. Nishino, and M. P. van der Laan (2025). Submitted to Wind Energy Science in March 2025.See readme.txt for more info about the data.
DOI: 10.15468/dl.tpj63e
title: Occurrence Download

description: A dataset containing 14053 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Corythopis delalandi (Lesson, 1831)"
 ]
}

 The dataset includes 14053 records from 50 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0015275-250310093411724/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.sh4y8v
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Pteronura brasiliensis Zimmermann, 1780"
 ]
}

 The dataset includes 0 records from 56 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0345388-200613084148143/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.tbafzc
title: Occurrence Download

description: A dataset containing 3101 species occurrences available in GBIF matching the query:
{
 "and" : [
 {
 "or" : [
 "BasisOfRecord is Observation",
 "BasisOfRecord is Machine Observation",
 "BasisOfRecord is Human Observation",
 "BasisOfRecord is Material sample",
 "BasisOfRecord is Literature Occurrence",
 "BasisOfRecord is Living Specimen",
 "BasisOfRecord is Unknown evidence"
 ]
 },
 "TaxonKey is Andropogon virginicus L."
 ]
}

 The dataset includes 3101 records from 23 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0047123-180508205500799/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.t7dk5z
title: Occurrence Download

description: A dataset containing 45753 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Cerastium tomentosum L.",
 "HasCoordinate is true",
 "HasGeospatialIssue is false"
 ]
}

 The dataset includes 45753 records from 353 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0078739-231120084113126/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.mkt8km
title: Occurrence Download

description: A dataset containing 64 species occurrences available in GBIF matching the query:
{
 "and" : [
 {
 "or" : [
 "Continent is Africa",
 "Continent is Europe",
 "Continent is Asia"
 ]
 },
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 "TaxonKey is Pentzia Thunb."
 ]
}

 The dataset includes 64 records from 9 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0094836-200613084148143/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.3km7cx
title: Occurrence Download

description: A dataset containing 1339 species occurrences available in GBIF matching the query:
{
 "and" : [
 {
 "or" : [
 "Country is Benin",
 "Country is Nigeria",
 "Country is Niger",
 "Country is Burkina Faso",
 "Country is Togo"
 ]
 },
 "Year 1950-2018",
 "HasCoordinate is true",
 "TaxonKey is Chromolaena odorata (L.) R.M.King & H.Rob.",
 "HasGeospatialIssue is false"
 ]
}

 The dataset includes 1339 records from 26 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0047124-180508205500799/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.rt66b7
title: Occurrence Download

description: A dataset containing 151 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Kellia simulans E.A.Smith, 1907",
 "HasGeospatialIssue is false",
 "HasCoordinate is true",
 {
 "not" : {
 "BasisOfRecord" : [
 "is Fossil"
 ]
 }
 },
 {
 "or" : [
 {
 "not" : {
 "EstablishmentMeans" : [
 "is MANAGED"
 ]
 }
 },
 {
 "not" : {
 "EstablishmentMeans" : [
 "is not null"
 ]
 }
 }
 ]
 },
 {
 "or" : [
 "OccurrenceStatus is Present",
 {
 "not" : {
 "OccurrenceStatus" : [
 "is not null"
 ]
 }
 }
 ]
 }
 ]
}

 The dataset includes 151 records from 15 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0056555-240229165702484/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.ueyckq
title: Occurrence Download

description: A dataset containing 6748 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Genipa L."
 ]
}

 The dataset includes 6748 records from 265 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0142695-200613084148143/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.8499fg
title: Occurrence Download

description: A dataset containing 73 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is Guatemala",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 "TaxonKey is Solanum demissum Lindl."
 ]
}

 The dataset includes 73 records from 6 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0044157-240506114902167/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.zzrfdy
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Mesochorus semirufus Holmgren, 1860",
 "HasCoordinate is true",
 "Country is Japan",
 "HasGeospatialIssue is false"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0217554-220831081235567/datasets/export for details.