cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.17632/5wbzddvhbx.1
title: Cisplatin Damaged Gene Loci

description: Cisplatin is a classical example of a DNA-targeted genotoxic anticancer drug, yet the exact gene loci attacked by cisplatin as well as the relationship between these gene lesions and action of the drug remain largely unexplored. In this work, we have used a forward chemical genetics method to localize and identify cisplatin damaged gene loci on the whole human genome. By combining affinity separation, high throughput sequencing and mapping to human genome (hg38), we have mapped 14012 protein-encoding genes containing platination lesions, of which 445 genes belong to 628 known gene targets for cancer therapy reported previously. Significantly, cisplatin induces lesions on 306 protein kinase genes with high fold-enrichment during our gene loci mapping, accounting for a remarkable 59% of putative human protein kinase genes. The cisplatin-damaged protein kinase genes are involved in 260 highly associated core-signaling pathways. The data deposited into this database are the mapping results of cisplatin damaged DNA for two biological replicates.
DOI: 10.17632/c5y648crcf.1
title: Performance-based design / code - fire engineering

description: Performance based codes as, with a performance of fire safety engineering, design fire scenario’s and design strategies. Performance based codes approach - how a building could see the fire extinguishing in case of fire. The expertise of having the performance based design (PBD) is quite accountable while having a design from prescriptive. Performance based design evaluate how building systems are having their system strategies in conditions, with hazards available. Performance objectives are the acceptable risk of level(s) of countable damage and the losses that occur as a result of this damage. The performance based design objectives are specific and with a strategy in a building, such as safe people during evacuation. The performance approach is, in essence, the practice of thinking and working in terms of ends rather than means. And concerned with what a building or building product is required to do. Performance-based design attributes as an engineering of fire protection based on a. fire safety in the building b. design basis of the building and c. engineering analysis. Evaluating and documenting performance based design seeks the criteria of design(s), and if criteria’s of design change after detailed, it may require a modification. Standards & codes of fire are intended to ensure the health, safety and well-being of people in buildings, to address means of egress, fire safety, hazard identification etc. The model employed in performance-based codes focuses on design outcomes. In other words, a performance based code - approach would identify and quantify the level of damage that is acceptable during and after a fire (design fire scenarios), earthquake or other event(s). The current prescriptive code focuses on solutions that achieve a countable outcome. The difficulty is that the outcome is unclear. Therefore, when a design is proposed that is different from the prescriptive code, it is often difficult to determine whether the approach will be equivalent. There may be other more appropriate and innovative solutions available.
DOI: 10.17632/68w8pcmcbb.3
title: Stan badań nad współczesnymi stosunkami polsko-rosyjskimi
DOI: 10.17632/3r525fbndd.1
title: T04B2.1 MS

description: The conventional notions of pseudogenes being ‘junk DNA’ have largely been offset as research studies have established their role in multiple biological processes. Our studies towards identification of genetic modulators employing C. elegans model, that associate reproductive health and age-related neurodegenerative diseases, led us to identification and functional characterization of a pseudogene T04B2.1, which when knocked out,exacerbates the aggregation of α-Synuclein and β-Amyloid proteins, induces lipid deposition and alters morphometric endpoints in worms. Whole transcriptome analysis of worms under knockdown condition of T04B2.1 revealed an altered expression of 187 sequences, most of these being non-coding RNAs, miRNAs and piRNAs modulating the RNAi regulatory processes. Our gene ontology and pathway enrichment analysis demonstrated the role of T04B2.1 in protein quality control, metabolic pathways and development. We further performed a signature motif search and successfully identified a common motif that is present between all piRNA and miRNA molecules, which are significantly altered upon T04B2.1 silencing. This study unveils the non-conventional regulatory role of pseudogene T04B2.1with respect to effects associated with neurodegenerative diseases and encourages further studies to decipher the regulatory mechanism governed by pseudogenes.
DOI: 10.17632/v8gnfjgwmr.2
title: Invaluable CTD and Mixed Layer Depth data in northern coast of the Bay of Bengal
DOI: 10.17632/mxhhxpvpvj.2
title: Ischaemic Postconditioning in Equine Jejunal Ischaemia

description: The objective of the study was to assess the feasibility of IPoC in equine jejunum, and to evaluate the effect of this treatment strategy on different variables of ischaemia reperfusion injury in experimental equine jejunal ischaemia. The authors hypothesized that IPoC clamping effectively reduces intestinal microperfusion in the equine jejunum, and that IPoC would ameliorate ischaemia reperfusion injury.
DOI: 10.21227/67yq-d049
title: Integrated transmission and distribution system expansion planning under uncertainty: Test data and results

description: Data and results for the 36- and the 334-node test systems used for the integrated expansion planning problem of transmission and distribution systems.
DOI: 10.17632/p9zhpmzgtk.1
title: Compact dataset of dendrochronological data of primary metric characteristics of tree rings of Asia.

description: The International Tree Rings Data Bank (ITRDB) is the most comprehensive tree growth database (https://www1.ncdc.noaa.gov/pub/data/paleo/treering). Shoudong Zhao, et al. (2019, 2018) analyzes the representativity of dendrochronological data (ITRDB) and proposes a corrected database with error indications. One of the bottlenecks for data use (ITRDB) is that the data is loaded as a collection of separate files in the Tucson positional format. The purpose of our data presentation is to change the data format to JSON and combine the separate files into one. On the example of data for Asia, it is proposed to use the Json format of tree growth data in a single file. When converting data, the programming language R and the library of programs dplR Bunn, A. (2008) were used The experience of developing the structure of dendroclimatic data in JSON format is described in the works of Kachaev A. (2016, 2017). The following is a description of the JSON format of dendrochronological data. {"site identifier": {"cap": {}, "rwl": {"wea": [{},…, {}], "wla "[{},…, {}]," Wri ": [{},…, {}]," dma ": [{},…, {}]," dmi ": [{},…, { }], "dea": [{},…, {}], "dla": [{},…, {}], "pla": [{},…, {}]}}} :: = "Coll": "identifier", "Scode": "tree view code", "Years": [, ], " Geo ": {" Lat ": ," Long ": ," Elev ": }," Comm ":" common name of the tree species " , "Locat": "site names", "Site": "site name", "Invest": "list of researchers' authors" :: = "Ntree": "tree identifier", "Years"; [, ], "Series": [,…, ] Further, the decoding of Tree Ring Measurement Type Codes of measurement codes in rwl-files: wea- earlywood width, dea- earlywood density, wla-latewood width, dmi-minimum density, wri-ring width, dla-latewood density, dma-maximum density, pla - latewood percent. References Bunn, A. G. (2008). A dendrochronology program library in R (dplR). Dendrochronologia, 26, 115-124. https://doi.org/10.1016/j.dendro.2008.01.002 Kachaev A. V. Model for describing the structure of dendroclimatic data In the col-lection: Regional problems of remote sensing of the Earth Materials of the IV international scientific conference. Siberian Federal University, Institute of Space and Information Technologies. 2017. p. 120-122. (Russia) Kachaev A. V. NOSQL Approach for Development of Dendroclimatic Data Bank. In the collection: Regional problems of remote sensing of the Earth. Materials of the III International Scientific Conference. 2016. p. 89-91. (Russia) Shoudong Zhao, et al. (2019). The International Tree-Ring Data Bank (ITRDB) revisited: Data availability and global ecological representativity. Journal of Biogeography, 46 (2), 355-368. doi: 10.1111 / jbi.13488
DOI: 10.17632/y2rkvdjggm.1
title: Repetitive mild traumatic brain injury affects inflammation and excitotoxic mRNA expression at acute and chronic time-points

description: A closed head weight drop model that replicates the biomechanics and head acceleration forces of human mTBI was used to provide an exploration of the acute and chronic outcomes following single and repeated impacts. Adult male C57BL/6J mice were randomly assigned into one of four impact groups (control; one, five and 15 impacts) which were delivered over 23 days. Outcomes were assessed 48 hours and 3 months following the final mTBI. Hippocampal spatial learning and memory assessment revealed impaired performance in the 15-impact group compared with control in the acute phase that persisted at chronic measurement. mRNA analyses were performed on brain tissue samples of the cortex and hippocampus using quantitative RT-PCR. Eight genes were assessed, namely: MAPT, GFAP, AIF1, GRIA1, CCL11, TARDBP, TNF, and NEFL, with expression changes observed based on location and follow-up duration. The cortex and hippocampus showed vulnerability to insult, displaying upregulation of key excitotoxicity and inflammation genes. Serum samples showed no difference between groups for proteins phosphorylated tau and GFAP. These data suggest that the cumulative effect of the impacts was sufficient to induce mTBI pathophysiology and clinical features. The genes investigated in this study provide opportunity for further investigation of mTBI-related neuropathology and may provide targets in the development of therapies that help mitigate the effects of mTBI.
DOI: 10.17632/tj8mf3htkc.1
title: Celecoxib in a preclinical model of repetitive mild traumatic brain injury: hippocampal learning deficits persist with inflammatory and excitotoxic neuroprotection

description: We sought to investigate molecular pathways involved in neuroinflammation in response to celecoxib treatment in a mouse model of subconcussive mTBI. 15 mTBIs were delivered over 23 days in adult male C57BL/6J mice in one of four groups (control; celecoxib without impact; celecoxib with impact, and vehicle with impact). Mice were assessed for cognitive function 48 hours and 3 months following the final mTBI. Morris Water Maze (MWM) testing revealed impaired hippocampal spatial learning performance in the celecoxib treatment group compared with control in the acute phase, with no improvement in celecoxib treatment compared with control at chronic testing. mRNA analysis of the cerebral cortex and hippocampus in the genes Mapt, Gfap, Aif1, Gria1, Tardbp, Tnf and Nefl revealed expression change indicating significant improvement in microglial activation, inflammation, excitotoxicity, and neurodegeneration at chronic measurement. These data suggest that in the acute phase following injury, celecoxib provided ineffective treatment against neuroinflammation and exacerbated clinical cognitive disturbance. Moreover, while there was evidence of neuroprotective alleviation of mTBI pathophysiology at chronic measurement, there remained no benefit in clinical features. The results of this study provide insight into the role of COX during inflammation and in the use of COX mediating drugs in the treatment of mTBI symptoms.
DOI: 10.17632/bvtdz78vv9.1
title: Minocycline improves cognition and molecular measures of inflammation and neurodegeneration following repetitive mTBI

description: To investigate minocycline treatment of mTBI neuroinflammation, we utilised a validated mouse model involving repetitive impact-induced rotational acceleration. Adult male C57BL/6J mice were randomly assigned into one of four impact groups (vehicle control; minocycline without impact; minocycline with impact, and vehicle with impact). 15 mTBIs were delivered, and outcomes were assessed 48 hours and 3 months following the final mTBI to assess the acute and chronic inflammatory responses. Hippocampal spatial learning and memory testing revealed no differences in the minocycline impact group compared to unimpacted controls in the chronic phase of recovery, indicating chronic neuroprotection. mRNA analyses were performed on brain tissue samples of the cortex and hippocampus using quantitative RT-PCR. Minocycline treatment of mTBI lead to improvement in microglial activation, inflammation, excitotoxicity, and neuron integrity in the chronic stage of recovery. These data suggest that minocycline treatment alleviated some mTBI pathophysiology and clinical features at chronic time-points.
DOI: 10.17632/dt5ydg2r4m.1
title: Unstimulated urinary oxytocin and cortisol metabolite concentrations in pack-living dogs and wolves

description: Dataset used for statistical analyses of unstimulated (baseline, resting) urinary oxytocin and glucocorticoid (cortisol) metabolite concentrations in hand-raised, pack-living dogs and wolves housed at the Wolf Science Center Austria. Description of hypotheses, detailed methods, and results published in Hormones and Behavior (Wirobski et al., 2021). Full reference to article: Wirobski, G., Range, F., Schaebs, F.S., Palme, R., Deschner, T., Marshall-Pescini, S., 2021. Endocrine changes related to dog domestication: Comparing urinary cortisol and oxytocin in hand-raised, pack-living dogs and wolves. Horm. Behav. 128, 104901. https://doi.org/10.1016/j.yhbeh.2020.104901
DOI: 10.17632/t74tgnz7h7.1
title: Wildfires_effects_Landsat_1990-2019

description: Data from Landsat Satellite imagery for measuring the effects of wildfires in California (1990-2019).
DOI: 10.5517/ccdc.csd.cc21pcns
title: CCDC 1897375: Experimental Crystal Structure Determination

description: Related Article: Dan Liu, Jun Cao, Jing Sun, Ru-Zhang Liu, Chao-Guo Yan|2020|Org.Lett.|22|8931|doi:10.1021/acs.orglett.0c03331
DOI: 10.5517/ccdc.csd.cc21pcqv
title: CCDC 1897377: Experimental Crystal Structure Determination

description: Related Article: Dan Liu, Jun Cao, Jing Sun, Ru-Zhang Liu, Chao-Guo Yan|2020|Org.Lett.|22|8931|doi:10.1021/acs.orglett.0c03331
DOI: 10.5517/ccdc.csd.cc21pcrw
title: CCDC 1897378: Experimental Crystal Structure Determination

description: Related Article: Dan Liu, Jun Cao, Jing Sun, Ru-Zhang Liu, Chao-Guo Yan|2020|Org.Lett.|22|8931|doi:10.1021/acs.orglett.0c03331
DOI: 10.5517/ccdc.csd.cc21pcsx
title: CCDC 1897379: Experimental Crystal Structure Determination

description: Related Article: Dan Liu, Jun Cao, Jing Sun, Ru-Zhang Liu, Chao-Guo Yan|2020|Org.Lett.|22|8931|doi:10.1021/acs.orglett.0c03331
DOI: 10.5517/ccdc.csd.cc21pcty
title: CCDC 1897380: Experimental Crystal Structure Determination

description: Related Article: Dan Liu, Jun Cao, Jing Sun, Ru-Zhang Liu, Chao-Guo Yan|2020|Org.Lett.|22|8931|doi:10.1021/acs.orglett.0c03331
DOI: 10.5517/ccdc.csd.cc21pcvz
title: CCDC 1897381: Experimental Crystal Structure Determination

description: Related Article: Dan Liu, Jun Cao, Jing Sun, Ru-Zhang Liu, Chao-Guo Yan|2020|Org.Lett.|22|8931|doi:10.1021/acs.orglett.0c03331
DOI: 10.5517/ccdc.csd.cc21pcw0
title: CCDC 1897382: Experimental Crystal Structure Determination

description: Related Article: Dan Liu, Jun Cao, Jing Sun, Ru-Zhang Liu, Chao-Guo Yan|2020|Org.Lett.|22|8931|doi:10.1021/acs.orglett.0c03331
DOI: 10.5517/ccdc.csd.cc21pcy2
title: CCDC 1897384: Experimental Crystal Structure Determination

description: Related Article: Dan Liu, Jun Cao, Jing Sun, Ru-Zhang Liu, Chao-Guo Yan|2020|Org.Lett.|22|8931|doi:10.1021/acs.orglett.0c03331
DOI: 10.5517/ccdc.csd.cc21pcz3
title: CCDC 1897385: Experimental Crystal Structure Determination

description: Related Article: Dan Liu, Jun Cao, Jing Sun, Ru-Zhang Liu, Chao-Guo Yan|2020|Org.Lett.|22|8931|doi:10.1021/acs.orglett.0c03331
DOI: 10.5517/ccdc.csd.cc25xn81
title: CCDC 2023533: Experimental Crystal Structure Determination

description: Related Article: Tedd C. Wiessner, Samuel Asiedu Fosu, Riffat Parveen, Nigam P. Rath, Bess Vlaisavljevich, William B. Tolman|2020|Organometallics|39|3992|doi:10.1021/acs.organomet.0c00584
DOI: 10.5517/ccdc.csd.cc25xn92
title: CCDC 2023534: Experimental Crystal Structure Determination

description: Related Article: Tedd C. Wiessner, Samuel Asiedu Fosu, Riffat Parveen, Nigam P. Rath, Bess Vlaisavljevich, William B. Tolman|2020|Organometallics|39|3992|doi:10.1021/acs.organomet.0c00584
DOI: 10.5517/ccdc.csd.cc25xnb3
title: CCDC 2023535: Experimental Crystal Structure Determination

description: Related Article: Tedd C. Wiessner, Samuel Asiedu Fosu, Riffat Parveen, Nigam P. Rath, Bess Vlaisavljevich, William B. Tolman|2020|Organometallics|39|3992|doi:10.1021/acs.organomet.0c00584
DOI: 10.7931/ke50-gg04
title: New Zealand wetland prokaryote 16S metabarcoding
DOI: 10.17632/f4ysyn9t58.2
title: Alternative Lengthening of Telomeres is a Self-Perpetuating Process in ALT-Associated PML Bodies

description: This data include the original images of western blots and microscopy for the paper titled "Alternative Lengthening of Telomeres is a Self-Perpetuating Process in ALT-Associated PML Bodies" Alternative lengthening of telomeres (ALT) is mediated by break-induced replication (BIR), but how BIR is regulated at telomeres is poorly understood. Here, we show that telomeric BIR is a self-perpetuating process. By tethering PML-IV to telomeres, we induced telomere clustering in ALT-associated PML bodies (APBs) and a POLD3-dependent ATR response at telomeres, showing that BIR generates replication stress. Ablation of BLM helicase activity in APBs abolishes telomere synthesis but causes multiple chromosome bridges between telomeres, revealing a function of BLM in processing inter-telomere BIR intermediates. Interestingly, the accumulation of BLM in APBs requires its own helicase activity and POLD3, suggesting that BIR triggers a feedforward loop to further recruit BLM. Enhancing BIR induces PIAS4-mediated TRF2 SUMOylation, and PIAS4 loss deprives APBs of repair proteins and compromises ALT telomere synthesis. Thus, a BLM-driven and PIAS4-mediated feedforward loop operates in APBs to perpetuate BIR, providing a critical mechanism to extend ALT telomeres.
DOI: 10.26180/5f800bdb46c09
title: Construction and validation of a psychometric tool for generational identity

description: There is a lack of a psychometric tool for generational identity. We have conducted two studies involving senior Bangladeshi nationals, containing both independence war veterans and non-veterans, to develop a new generational identity scale (GIS). The first study (<i>N</i>=300) prepared an initial pool of 31 items and got them vetted by expert judges, which retained 21 items to form the provisional GIS (GIS-21). An exploratory factor analysis on GIS-21 excluded nine items and offered a two-factor solution: (i) identification with the generation and (ii) awareness of the generational importance. The second study (<i>N</i>=176) ran a confirmatory factor analysis on the resulting GIS-12 and dropped another item to achieve a better model fit (<i>χ<sup>2</sup>/df</i> =74.74/42 =1.78, <i>CFI</i> =0.96, <i>TLI</i> =0.95, <i>RMSEA</i> =0.05, and <i>SRMR</i> =0.05). The remaining 11-item GIS (GIS-11) showed excellent reliability (mean inter-item correlation coefficient =.44, Cronbach’s alpha =.89) and satisfactory temporal stability (<i>ICC</i> =.61, 95% <i>CI</i> =0.30 to 0.78) over a 4-week interval. The Bangladesh independence war veterans scored higher on GIS-11 than did the non-veterans, indicating the scale’s diagnostic validity. The scale’s moderate correlation (<i>r<sub>s</sub></i>=.63, <i>p</i>
DOI: 10.17632/89ffrjmd3m.1
title: Food and physical activity built environments. A database from the Southern Cone of Latin America

description: An obesogenic (obesity-promoting) environment is one that promotes higher dietary energy intakes and sedentary behaviors, while limiting opportunities or incentives for active living (including active transport and leisure-time physical activity). Built environments influence obesity through both food and physical activity pathways, and may contribute to the social gradient in obesity and related-NCD outcomes. This dataset contains information about food and physical activity attributes of the built environment from four cities of the Southern Cone of Latin America: Marcos Paz and Bariloche (Argentina), Temuco (Chile) and Canelones-Barros Blancos (Uruguay). Standardized community walks in representative neighborhoods were conducted for direct observation of the built environment in each city . The adapted instruments based on the following observation tools were used: EPOCH-1 to assess the streets, sidewalks and surrounding; POS to characterize the public open spaces; and NEMS-S to evaluate the food stores and restaurants. Published files: - Metadata, contains descriptive information of each file - Protocol - CRFs - Dataset (format csv) - Data dictionary
DOI: 10.17632/srtb8gnrkp.1
title: Fear to COVID_second wave (Cuba)

description: This dataset corresponds to the manuscript entitled "Anxiety, health self-perception, and worry about the resurgence of COVID-19 predict fear reactions among genders in the Cuban population"
DOI: 10.17632/kv3bnscc8b.3
title: Positron_electron_rrea

description: RREA generation probability with an electron/positron seed regarding the paper "Generation possibility of gamma-ray glows induced by photonuclear reactions" by Gabriel Diniz, Ivan Soares Ferreira, Teruaki Enoto and Yuuki Wada. Following simulation codes by Sarria et al. (2018), available at: https://gmd.copernicus.org/articles/11/4515/2018/
DOI: 10.17632/wwnvw28n2m.1
title: Lower Limb Kinematic, Kinetic and Spatial-temporal Gait Data for Healthy Adults Using a Self-paced Treadmill

description: The data presented in this repository, acquired from 100 “normal” participants of different ages, will provide a valuable gait dataset for future work and studies examining locomotion in humans.
DOI: 10.17632/9b264dw38s.1
title: Phylogeny_of_foetal_haematopoiesis_2020_LCM_images

description: These are the histological images to accompany the manuscript "Lineage tracing of human embryonic development and foetal haematopoiesis through somatic mutations" (bioRxiv 2020.05.29.088765; doi: https://doi.org/10.1101/2020.05.29.088765). The laser capture micro-dissection (LCM) images were taken from the camera on the laser-capture microdissection system (Leica LMD7) at 20-40x magnification. In most cases there are images from before and after LCM to illustrate the precise area cut and subjected to targeted or whole-genome sequencing. The slide scanner images (ending .ndpi) are high-resolution histology images taken with a Hamamatsu slide scanner, and should be viewed together with the corresponding annotation file (ending .ndpa) which highlights the areas undergoing LCM, and the corresponding unique identifier. They can be viewed using freely available software NDP.view (available at https://www.ndpserve.com/ndp/serve/home). The tissues are 5-10um thick and are from two human foetuses of 8- and 18-pcw weeks as described in manuscript. For the 8-pcw foetus there are images taken from epidermis, connective tissue of the limb, inter-vertebral discs, kidney, gut, heart, blood from inside the chambers of the heart and placenta. For the 18-pcw foetus there are images from the epidermis, hair follicles, peripheral nerves, heart and kidney.