cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.24145488
title: Supplementary Material for: Novel approach to intradialytic progressive resistance exercise training

description: Physical activity levels are typically undesirably low in chronic kidney disease patients, especially in those undergoing haemodialysis, and particularly on dialysis days. Intradialytic exercise programmes could be a solution to this issue and have been reported to be safe and relatively easily implemented in dialysis clinics. Nevertheless, such implementation has been failing in part due to barriers such as the lack of funding, qualified personnel, equipment, and patient motivation. Intradialytic aerobic exercise has been the most used type of intervention in dialysis clinics. However, resistance exercise may be superior in eliciting potential benefits on indicators of muscle strength and mass. Yet, few intradialytic exercise programmes have focused on this type of intervention and the ones which have report inconsistent benefits, diverging on prescribed exercise intensity, absent or subjective load progression, equipment availability, or exercise supervision. Commonly, intradialytic resistance exercise interventions use free weights, ankle cuffs or elastic bands which hinder load progression and exercise intensity monitoring. Here, we introduce a recently developed intradialytic resistance exercise device and propose an accompanying innovative resistance exercise training protocol which aims to improve the quality of resistance exercise interventions within dialysis treatment sessions.
DOI: 10.6084/m9.figshare.24174141
title: Supplementary Material for: 'Brait-Fahn-Schwartz Disease: A Unique Co-occurrence of Parkinson's Disease and Amyotrophic Lateral Sclerosis.'

description: Background: The Parkinson's disease-amyotrophic lateral sclerosis complex typically manifests as levodopa-responsive parkinsonism followed by ALS. It is extremely rare for PD and ALS to coexist without other neurological disorders. Named after the scientists who first described this overlap of two neurodegenerative conditions is referred as Brait-Fahn-Schwartz disease. The most notable characteristics that set this disorder apart from Guam parkinsonism-dementia complex, are the positive and persistent response to dopaminergic drug therapy and the order in which progressive parkinsonian symptoms and signs appear before the onset of ALS. Given its variable presentations, increasing rarity and the lack of any diagnostic test, it poses a diagnostic challenge. Case presentation: We report a rare case of a 55 years old Pakistani male, who presented to us with progressive quadriparesis, which was spastic in nature in lower limbs and flaccid in upper limbs, along with preceding cardinal features of idiopathic Parkinson’s disease. We arrived at our diagnosis after rigorous history taking and physical examination with supportive aid of radiological imaging and electromyography. On presentation, spasticity had disabled the patient to the extent of requiring one-person support to walk. However, with only 2 weeks on our treatment plan, targeting both PD and ALS, he could walk unaided. Since there is currently no cure available for either PD or ALS, all available treatment focuses on improving quality of life, which we achieved in our patient. Conclusion: This case is unique in being the first incidence of PD-ALS complex in a novel geographic region such as Pakistan where the genetic testing and cost constraints limit the diagnosis of rare disorders. The coexistence of extrapyramidal symptoms and pyramidal symptoms is uncommon. In such situations, physicians may overlook one group of symptoms, potentially leading to a misdiagnosis. This case highlights the value of a thorough physical examination, electrodiagnostic studies and suggest the association of PD and ALS. This case demonstrates the significance of understanding when PD symptoms start to appear in patients with ALS and the need to start dopaminergic therapy in those who had Parkinsonism features before ALS to alleviate the suffering of an individual, and enhances quality of life.
DOI: 10.6084/m9.figshare.23585250
title: Supplementary Material for: Dupilumab for chronic prurigo: case series on effectiveness, safety, and quality of life

description: Background Chronic prurigo (CPG) is a pruritic skin disease, characterized by an itch–scratch cycle and scarring. It reduces patients’ quality of life (QoL). Dupilumab is a monoclonal human IgG antibody that inhibits signaling of the interleukin 4 (IL-4) and interleukin 13 (IL-13) pathways through blockade of the IL-4 receptor (IL-4R). Patients with CPG who receive dupilumab often report great improvement in itch and overall QoL. We therefore reviewed our experience in order to follow up on QoL, safety, and treatment response in patients with CPG who received dupilumab. Methods We conducted a real-world retrospective single-center case series. Outcomes were assessed by phone interviews and photographs using validated questionnaires and scores. Demographic data were obtained from the hospital files. Follow-up was up to 2 years. We assessed quality of life with the Dermatology Life Quality Index (DLQI) and the Itchy quality of life questionnaire (ItchyQoL). Numerical Rating Scale (NRS) was used to assess itch. Prurigo lesions were documented with the Prurigo activity and severity score (PAS). Results Ten patients were included in this study. Results were reported up to two years after treatment with dupilumab. The response variables for DLQI, ItchyQoL, NRS and PAS analyses showed a statistically significant decrease over time (DLQI: (p = &lt; 0.0001, [-0.84; -1.27]), ItchyQoL: (p = &lt; 0.0001, [-9.89; -18.69], NRS maximum and average: p = &lt; 0.0001, [-0.52; -0.86] and p = &lt; 0.0001; [-0.55; -0.94] and PAS number of lesions: p = 0.0005; [-1.70; -5.28]). The percent decrease after one year of treatment (this estimate is based on model estimates) ranges from -42% to -82%. Four (40%) patients reported mild side effects. No serious side effects were reported. Conclusion Dupilumab treatment of CGP for up to two years is associated with improved QoL and less itching.
DOI: 10.6084/m9.figshare.24024345
title: Supplementary Material for: Recurrence of large-vessel vasculitis induced by multiple types of Granulocyte colony-stimulating factor preparation in patient with large cell neuroendocrine lung carcinoma: a case report

description: With the increased use of granulocyte colony-stimulating factor (G-CSF) preparations, there is concern about the increase in G-CSF-associated large-vessel vasculitis; however, there have been no previous reports of vasculitis caused by multiple types of G-CSF preparations. We experienced a case of drug-induced large-vessel vasculitis caused by two different G-CSF products, which was difficult to diagnose. When treating patients with a history of large-vessel vasculitis caused by pegfilgrastim, we need to pay attention to its recurrence when using other G-CSF preparations.
DOI: 10.6084/m9.figshare.24025599
title: Supplementary Material for: The initial journey of patients with metastatic pancreatic cancer (PaCTO project): a nationwide survey among Portuguese specialist physicians

description: Introduction: We aimed to characterize the initial healthcare journey of metastatic pancreatic ductal adenocarcinoma (mPDAC) patients in Portugal, including healthcare provision and factors affecting therapeutic decisions, namely BRCA mutations testing. Methods: This is a descriptive cross-sectional, web-based survey using a convenience sampling approach. Portuguese oncologists and pathologists that routinely work with mPDAC patients from the different geographical regions and settings were invited to participate in the study via email (December 2020). Descriptive statistical analyses were performed, with categorical variables reported as absolute and relative frequencies, and continuous variables with non-normal distribution as median and interquartile range (IQR) (Stata v.15.0). Results: Seventy physicians participated in the study (43 oncologists, 27 pathologists). According to the responses, a median of 28 patients per center (IQR 12-70) was diagnosed with PDAC in the previous year; 22 of them referring (IQR 8-70) to mPDAC. The pointed median time from patients’ first hospital admission until disease diagnosis/staging is between 2-4 weeks. Endoscopic ultrasound with fine needle biopsy (EUS-FNB) is available in most hospitals (86%). Around 50% of physicians request BRCA testing; the assessment of additional biomarkers besides BRCA is requested by 40% of professionals. Half of them stated that BRCA testing should be requested earlier - upon histological diagnosis, especially because the median time for results is of 4.0 weeks (IQR 4-8). PARP inhibitors such as olaparib, when available, would be the therapy of choice for most oncologists (71%) if no disease’ progression occurs after four months. Treatments’ selection is usually grounded on clinical criteria (e.g. performance status, liver function). Around 45% of patients use FOLFIRINOX/mFOLFIRINOX as first-line therapy. Gemcitabine+nab-paclitaxel is used by 35% of patients as second-line therapy. Discussion/Conclusions: Physicians in Portugal support the increasing role of patient-tailored treatments in mPDAC, whose selection should be grounded on tumoral subtyping and molecular profiling. Further efforts to develop multidisciplinary teams, standardized clinical practice and optimize the implementation of new target therapies are needed.
DOI: 10.6084/m9.figshare.24031713
title: Supplementary Material for: Clinical Value of clip-and-snare assisted endoscopic submucosal resection in Treatment of Rectal Neuroendocrine Tumors

description: Introduction: To introduce a new endoscopic technology, clip-and-snare assisted endoscopic submucosal resection (CS-ESMR) for treatment of rectal neuroendocrine tumors (NETs), and then to investigate the therapeutic value of CS-ESMR. Methods: In this retrospective study, 67 patients who underwent endoscopic treatment of rectal NETs from March 2017 to Dec 2021 were analyzed. According to the endoscopic resection methods (EMR, CS-ESMR and endoscopic submucosal dissection (ESD)), the cases were divided into CS-ESMR group (27 cases), ESD group (31 cases), and EMR group (9 cases). The pathological R0 resection rate and the incidence of adverse events (bleeding and perforation) were compared among the three groups. Results: There was a significant difference about the pathological R0 resection between the CS-ESMR group and the EMR group and between the CS-ESMR group and the ESD group(both P&lt;0.05); Compared with ESD group, the procedure time, intraoperative bleeding and the cost of CS-ESMR group are significantly decreased (P&lt;0.001, P&lt;0.05, P&lt;0.001, respectively). Conclusion: CS-ESMR may be a safe and effective treatment for rectal NETs with a diameter of less than 10mm, without muscularis propria invasion and metastasis.
DOI: 10.6084/m9.figshare.24057012
title: Supplementary Material for: Exocrine pancreatic insufficiency possibly related to atypical chronic graft-versus-host disease

description: We report the case of a 66-year-old woman who presented with diarrhea and weight loss approximately fourteen months after unrelated allogeneic bone marrow transplantation for acute myeloid leukemia. Her early post-transplant course was notable for mild acute skin graft-versus-host disease (GVHD) and biopsy-proven upper gastrointestinal (GI) acute GVHD, both of which resolved with treatment. She then developed weight loss and diarrhea treated with prednisolone for what was thought to be GI late acute GVHD. However, her diarrhea and weight loss persisted. Colonoscopyn biopsies showed a grossly intact mucosa, and stool studies only confirmed steatorrhea. were negative for GI late acute GVHD; Hhowever, an atrophic pancreas was found on an abdominal computed tomography (CT) scan. Exocrine pancreatic enzymes, such as lipase and pancreatic amylase, were markedly decreased, yet pancreatic endocrine function remained intact. The patient’s diarrhea and weight loss improved upon treatment with pancrelipase. Therefore, we suggest that her exocrine pancreatic insufficiency was likely partly caused mediated by atypicalpossibly related to atypical chronic GVHD.
DOI: 10.6084/m9.figshare.24099498
title: Supplementary Material for: First Reported Case of a Pyrophosphate Kidney Stone in a Human

description: Urolithiasis composed of pyrophosphate salts have only been reported in animals, in the form of potassium magnesium pyrophosphate. However, there have been no reports of pyrophosphate stones in humans. Hypophosphatasia is an inherited disease characterized by low alkaline phosphatase activity and elevated levels of pyrophosphate in blood and urine. Urolithiasis is a part of the hypophosphatasia phenotype. The role of elevated urine pyrophosphate levels in the formation of stones in hypophosphatasia is unknown. Here we report a case of a 60 year old man with recurrent urolithiasis. The patient’s most recent presentation was gross hematuria and his CT scan showed bilateral kidney stones. Stones were removed via retrograde intra-renal surgery. Stone analysis revealed a composition of potassium magnesium pyrophosphate. The patient also has a long history of fracturing bone disease which led to the consideration of hypophosphatasia as the cause of both his bone disease and pyrophosphate stones. Hypophosphatasia was confirmed by genetic analysis. Pyrophosphate has been of interest in the fields of mineral metabolism because of its action as a crystallization inhibitor. However, pyrophosphate at elevated concentrations in the presence of divalent cations can exceed its solubility. Nephrocalcinosis and stone disease have been described in hypophosphatasia, stones have been assumed to be calcium phosphate but no compositional analysis has been reported. This is the first report of human stones composed of pyrophosphate salts, which led to the subsequent diagnosis of hypophosphatasia in this patient.
DOI: 10.17632/3mh8m429pv.2
title: Nutritional profiles of Spirulina, Chlorella, Durum Wheat, Sweet Potato and the House Cricket.

description: Raw data collected from 43 literature studies on the percentage amino acids, lipids, total protein content, total lipid content, total carbohydrate content and total ash content. Used to make figure four bar charts in 'Cyanobacteria and microalgae in supporting human habitation on Mars'.
DOI: 10.25573/data.11799201.v2
title: Yearly Reports_Bocas del Toro

description: Yearly climate summaries for the Smithsonian Tropical Research Institute's Physical Monitoring Program Bocas del Toro Research Station, located on San Juan Island in the Rep. of Panama.<br><br>This report summarises data for the Bocas del Toro Research Station. The station was established in 2002. Located near the western end of Isla Colon (9.351553°, -82.256565°); part of the Bocas del Toro Archipelago. The archipelago is a complex region of islands, mainland bays, rivers and forested mountain slopes on the Caribbean side of the Panamanian isthmus. <br><br>Summaries include the climate data collected from the meteorological station located on a platform located approximately 200m from the shore, as well as oceanographic data collected from numerous sampling sites located in the surrounding area.
DOI: 10.48670/moi-00266
title: Mediterranean Sea Surface Temperature extreme from Reanalysis
DOI: 10.5281/zenodo.1175609
title: Growth Temperatures For 21,498 Microorganisms

description: This dataset contains species names and growth temperatures for 21,498 microorganisms (archaea, bacteria and eukaryotes). The dataset has been described in a peer-reviewed paper (https://doi.org/10.1186/s12866-018-1320-7), please cite both the paper as well as the DOI of this dataset if you make use of the data.

 

The data in the .tsv flat-file file is tab-delimited. Strain designations have explicitly been removed from the species names. Temperatures are given in degrees Celsius. Additional information given for each strain include: which domain (superkingdom) the organism belongs to, the organisms taxonomic identifier, taxonomic lineage as text, as well as the taxonomic lineage parsed into the categories superkingdom phylum, class, order, family, genus. Taxonomy is based on the NCBI taxonomic database, which is not authoritative, and may therefore contain errors. Missing values are indicated by NA.
description: {"references": ["https://doi.org/10.1186/s12866-018-1320-7"]}
DOI: 10.5281/zenodo.7105991
title: The June 2012 North American Derecho: A testbed for evaluating regional and global climate modeling systems at cloud-resolving scales

description: This is the companion data for the manuscript titled 'The June 2012 North American Derecho: A testbed for evaluating regional and global climate modeling systems at cloud-resolving scales', submitted to the Journal of Advances in Modeling Earth Systems in September 2022. derecho_simulation_result: this folder contains part of the SCREAM RRM outputs I ran on NERSC Cori in 2021-2022 corresponding to the simulation in Table 1 of the manuscript. wrf_simulation_result: this folder contains part of the WRF outputs run by Jianfeng Li from PNNL (jianfeng.li@pnnl.gov) in 2022 corresponding to the simulations in Table 4 of the manuscript. plot_script: this folder includes python scripts to plot figures shown in the manuscript. ASOS_station: this txt file contains the processed ASOS station wind speed used in the manuscript. <br> Unfortunately, all model outputs are large (~ 3.8 TB for SCREAM RRM and 3.1 TB for WRF). Therefore, I only provide the variables (i.e., OLR, precipitation, composite radar reflectivity, and 10-m wind speed) used directly to generate figures in this repository. All model outputs are archived on tape at NERSC. For more details, refer to the manuscript, or contact me (wrliu@ucdavis.edu).
DOI: 10.5281/zenodo.7156704
title: Crystal structure of a 1:1 cocrystal of OPC-167832 with 2,5-dihydroxybenzoic acid using microcrystal electron diffraction

description: The title cocrystal, OPC-167832 (5-(((3R,4R)-1-(4-chloro-2,6-difluorophenyl)-3,4-dihydroxypiperidin-4-yl)methoxy)-8-fluoro-3,4-dihydroquinolin-2(1H)-one); C<sub>21</sub>H<sub>20</sub>ClF<sub>3</sub>N<sub>2</sub>O<sub>4</sub>) and 2,5-dihydroxybenzoic acid (2,5DHBA; C<sub>7</sub>H<sub>6</sub>O<sub>4</sub>) were successfully cocrystallized and the crystal structure was solved via microcrystal electron diffraction.
DOI: 10.5281/zenodo.8326112
title: STEP UP project: the Weierbach dataset 2019-2020

description: Understanding the interaction between topography and vegetation across different environments is important to assess how hydrological and climatic conditions affect tree physiological activity. This becomes especially important given the expected reduction in water availability and increase in water demand driven by climate change. These extremes could enhance the thermal and hydrologic gradients along slopes. Multiple studies that investigated the effect of water limitations on forest vulnerability have neglected landscape heterogeneity at fine spatial resolutions, even though soil properties and topography are important abiotic factors for forest health (Schwantes et al., 2018). STEP-UP (Space-time patterns of tree water uptake at hillslopes with contrasting climate and geology) project aimed to investigate the spatio-temporal dynamics of water sources for beech trees (<em>Fagus sylvatica </em>L.). This species is abundant in many temperate European forest ecosystems, which could be strongly impacted by the predicted intensification of dry and wet spells (IPCC, 2023). The aim of the project is to get a better understanding of how climate, geology, and topography shape beech tree water uptake patterns along the catena by using a combination of hydro-meteorological observations, sap velocity measurements, and δ2H and δ18O measurements sampled in groundwater, soil water, and xylem water. For this purpose, we conducted a comparative study on a gentle (10 degrees) hillslope in the Weierbach catchment in Luxembourg (oceanic climate) (see Fabiani et al., 2022) and a steep (30 degrees) hillslope in the Lecciona catchment in Italy (Mediterranean climate). In this dataset, we present the data collected over 2019 and 2020 in the Weierbach catchment only. This dataset encompasses the following files: - conceptual figure named “Conceptual_figure_Weierbach_Lecciona” - daily sap velocity from three beech trees named “Weierbach_sapvelocity_2019-2020” - isotopic database (d<sup>18</sup>O and d<sup>2</sup>H) of xylem water, soil, groundwater, stream and precipitation named "Weierbach_isotopes_dataset_2019-2020" Sapflow sensors installation, maintenance and data cleaning were performed by Ginevra Fabiani and Remy Schoppach in the framework of EFFECT and STEP UP projects (AFR/STEP-UP ID 12546983 and FNR/CORE/C17/SR/11702136/EFFECT). Xylem, soil and water samples were collected, treated and analyzed by Ginevra Fabiani. Soil samples of 2020 were analyzed by Adnan Moussa. Julian Klaus, Daniele Penna and Laurent Pfister were responsible for founding acquisition and project management.
description: The authors acknowledge funding from the Luxembourg National Research Fund (FNR) (AFR/STEP-UP ID 12546983 and FNR/CORE/C17/SR/11702136/EFFECT) and the support of the Luxembourg Institute of Science and Technology (LIST).
DOI: 10.5281/zenodo.8419809
title: Results of the ISMRM 2020 joint Reproducible Research & Quantitative MR study groups reproducibility challenge on phantom and human brain T<sub>1</sub> mapping

description: This dataset includes both raw data and processed T1 maps obtained from the 2020 challenge on inversion recovery T1 mapping organized by the International Society in Magnetic Resonance in Medicine (ISMRM) Reproducible Research Study Group (RRSG). For a comprehensive overview of the data distribution submitted for this challenge, please visit https://rrsg2020.db.neurolibre.org. It's important to note that this dataset exclusively comprises ISMRM-NIST system phantom data. Dataset provided for NeuroLibre preprint. Author repo: https://github.com/rrsg2020/paper NeuroLibre fork:https://github.com/roboneurolibre/paper For details, please visit the corresponding NeuroLibre technical screening. <strong>https://neurolibre.org</strong>
DOI: 10.6084/m9.figshare.22188904
title: Supplementary Material for: Delayed perforation of colorectal endoscopic submucosal dissection treated by endoscopic ultrasound-guided drainage

description: We report a case of a 70-year-old male with delayed perforation in the cecum treated by endoscopic ultrasonography-guided drainage for a pelvic abscess. The lesion was a 50-mm laterally spreading tumor, and endoscopic submucosal dissection (ESD) was performed. No perforation was detected during the operation, and en block resection was achieved. He had fever and abdominal pain on postoperative day (POD) 2. Computed tomography revealed the intraabdominal free air, leading to a diagnosis of delayed perforation after ESD. Vital signs were stable, the perforation was considered minor, and endoscopic closure was attempted. The colonoscopy under fluoroscopy showed no perforation in the ulcer and no leakage of the contrast medium. He was managed conservatively with antibiotics and nothing per os. Symptoms improved; however, a follow-up CT on POD 13 revealed a 65-mm pelvic abscess, and endoscopic ultrasound (EUS)-guided drainage was successfully performed. The follow-up CT on POD 23 showed the reduction of abscess, and the drainage tubes were removed. Emergent surgical treatment is crucial in delayed perforation because it has a poor prognosis, and reports of conservative therapy for colonic ESD with delayed perforation are few. The present case was managed with antibiotics and EUS-guided drainage. Thus, EUS-guided drainage can be a treatment option for delayed perforation after colorectal ESD, if the abscess is localized.