cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.7270/q2cv4j51
title: BindingDB Entry 50034056: Non-steroidal dissociated glucocorticoid agonists: indoles as A-ring mimetics and function-regulating pharmacophores.

description: Small molecule binding data for protein Glucocorticoid receptor, Mineralocorticoid receptor (MR), and Progesterone receptor, Uniprot P04150, P06401, and P08235
DOI: 10.7270/q2dz08mc
title: BindingDB Entry 50033192: Structure based design, synthesis and SAR of cyclic hydroxyethylamine (HEA) BACE-1 inhibitors.

description: Small molecule binding data for protein Beta-secretase 1 and Cathepsin D, Uniprot P07339 and P56817
DOI: 10.7270/q2fj2h04
title: BindingDB Entry 50032372: Role of the phenolic hydroxyl group in the biological activities of simplified analogue of aplysiatoxin with antiproliferative activity.

description: Small molecule binding data for protein PKC alpha and beta-2, Protein kinase C alpha type, Protein kinase C delta type, Protein kinase C theta type, Protein kinase C, epsilon, Protein kinase C, eta, and Protein kinase C, gamma, Uniprot P05129, P05771, P17252, P24723, Q02156, Q04759, and Q05655
DOI: 10.7270/q2h995bb
title: BindingDB Entry 50031414: Novel multiple opioid ligands based on 4-aminobenzazepinone (Aba), azepinoindole (Aia) and tetrahydroisoquinoline (Tic) scaffolds.

description: Small molecule binding data for protein Delta-type opioid receptor, Nociceptin/mu opioid receptor, Opioid receptors; mu & delta, and mu/kappa opioid receptor, Uniprot P32300, P33533, P33535, and P97266
DOI: 10.7270/q2hd7vpc
title: BindingDB Entry 50030432: Pyrimido[5,4-e][1,2,4]triazine-5,7(1H,6H)-dione derivatives as novel small molecule chaperone amplifiers.

description: Small molecule binding data for protein Heat shock factor protein 1, Uniprot Q00613
DOI: 10.7270/q2hh6kg1
title: BindingDB Entry 50034055: Identification of 4-quinolone derivatives as inhibitors of reactive oxygen species production from human umbilical vein endothelial cells.

description: Small molecule binding data for protein Cytochrome P450 2D6 (2D6), Uniprot P10635
DOI: 10.7270/q2jm29xc
title: BindingDB Entry 50033191: Development of selective and reversible pyrazoline based MAO-B inhibitors: virtual screening, synthesis and biological evaluation.

description: Small molecule binding data for protein Amine oxidase [flavin-containing] A, Amine oxidase [flavin-containing] B, Monoamine Oxidase Type B (MAO-B), and Monoamine oxidase, Uniprot P19643, P21396, P21397, and P27338
DOI: 10.7270/q2n29x34
title: BindingDB Entry 50031412: Radiosynthesis of novel carbon-11-labeled triaryl ligands for cannabinoid-type 2 receptor.

description: Small molecule binding data for protein Cannabinoid receptor 1, Cannabinoid receptor 2, and Cannabinoid receptor 2 (CB2), Uniprot P21554, P34972, and Q9QZN9
DOI: 10.7270/q2n58md3
title: BindingDB Entry 50030431: Identification of a chromone-based retinoid containing a polyolefinic side chain via facile synthetic routes.

description: Small molecule binding data for protein Retinoid X receptor gamma/retinoic acid receptor alpha and Retinoid receptor, Uniprot P10276, P10826, and P13631
DOI: 10.7270/q2n87b59
title: BindingDB Entry 50034054: Oligopeptide cyclophilin inhibitors: a reassessment.

description: Small molecule binding data for protein Cyclophilin A, Uniprot P62937
DOI: 10.7270/q2p26zbv
title: BindingDB Entry 50032379: A stereo-controlled synthesis of 2,4-dimethyl-4-hydroxy-16-phenylhexadecanoic acid 1,4-lactone and its PPAR activities.

description: Small molecule binding data for protein Peroxisome proliferator-activated receptor alpha and Peroxisome proliferator-activated receptor delta, Uniprot P23204 and P35396
DOI: 10.7270/q2pc32n3
title: BindingDB Entry 50033190: Synthesis and pharmacological evaluation of novel benzoylazole-based PPARa/¿ activators.

description: Small molecule binding data for protein Peroxisome proliferator-activated receptor, Peroxisome proliferator-activated receptor alpha, and Peroxisome proliferator-activated receptor alpha (PPAR alpha), Uniprot P23204, P37231, and Q07869
DOI: 10.7270/q2rv0nv4
title: BindingDB Entry 50031410: Design, synthesis, evaluation and QSAR analysis of N(1)-substituted norcymserine derivatives as selective butyrylcholinesterase inhibitors.

description: Small molecule binding data for protein Acetylcholinesterase and Butyrylcholinesterase, Uniprot P21836 and Q03311
DOI: 10.7270/q2rx9c4h
title: BindingDB Entry 50030430: Optimization of 2-piperidin-4-yl-acetamides as melanin-concentrating hormone receptor 1 (MCH-R1) antagonists: Designing out hERG inhibition.

description: Small molecule binding data for protein GPR145, Melanin-concentrating hormone receptor, Voltage-gated potassium channel, and Voltage-gated sodium channel subunit Nav1.5, Uniprot Q12809, Q14524, Q969V1, and Q99705
DOI: 10.7270/q2s182wm
title: BindingDB Entry 50034053: Computational techniques are valuable tools for the discovery of protein-protein interaction inhibitors: the 14-3-3s case.

description: Small molecule binding data for protein 14-3-3 protein sigma, Uniprot P31947
DOI: 10.7270/q2st7q28
title: BindingDB Entry 50032378: Structure-based optimization of pyrazolo-pyrimidine and -pyridine inhibitors of PI3-kinase.

description: Small molecule binding data for protein DNA-dependent protein kinase, PI3-kinase subunit alpha, PI3-kinase subunit beta, PI3-kinase subunit delta, PI3-kinase subunit gamma, and Serine/threonine-protein kinase mTOR, Uniprot O00329, P42336, P42338, P42345, P48736, and P78527
DOI: 10.7270/q2t43tcf
title: BindingDB Entry 50033189: Synthesis and structure-activity relationships of phenylpropanoid amides of serotonin on tyrosinase inhibition.

description: Small molecule binding data for protein Tyrosinase, Uniprot O42713
DOI: 10.7270/q2tt4r6n
title: BindingDB Entry 50032369: Fatty acid synthase inhibitors of phenolic constituents isolated from Garcinia mangostana.

description: Small molecule binding data for protein Fatty acid synthase (FAS), Uniprot P49327
DOI: 10.7270/q2wm1djd
title: BindingDB Entry 50031409: Identification of piperazine-bisamide GHSR antagonists for the treatment of obesity.

description: Small molecule binding data for protein 5-Hydroxytryptamine receptor 2A (5-HT2A), 5-Hydroxytryptamine receptor 2C (5-HT2C), Alpha-2A adrenergic receptor, Dopamine receptor, Dopamine receptor D2L/neurotensin receptor NTS1, Ghrelin receptor, Histamine H2 Receptor, Kappa-type opioid receptor, Mu-type opioid receptor, Muscarinic acetylcholine receptor, Serotonin and norepinephrine transporters (SERT/NET), Sodium-dependent dopamine transporter, Sodium-dependent noradrenaline transporter, and Voltage-gated potassium channel, Uniprot O08725, P08913, P14416, P20309, P23975, P25021, P28223, P28335, P31645, P35372, P35462, P41145, Q01959, Q12809, and Q92847
DOI: 10.7270/q2wq03vc
title: BindingDB Entry 50030429: Design and synthesis of orally bioavailable serum and glucocorticoid-regulated kinase 1 (SGK1) inhibitors.

description: Small molecule binding data for protein Serine/threonine-protein kinase Sgk1, Uniprot O00141
DOI: 10.7270/q2ws8tn3
title: BindingDB Entry 50034052: Characterization of a novel and selective CB1 antagonist as a radioligand for receptor occupancy studies.

description: Small molecule binding data for protein Cannabinoid receptor, Cannabinoid receptor 1, and Cannabinoid receptor 2, Uniprot P20272, P21554, and P34972
DOI: 10.7270/q2xk8fsk
title: BindingDB Entry 50032377: Design and synthesis of hydroxyethylamine (HEA) BACE-1 inhibitors: structure-activity relationship of the aryl region.

description: Small molecule binding data for protein Beta-secretase 1 and Cathepsin D, Uniprot P07339 and P56817
DOI: 10.7270/q2xw4k3v
title: BindingDB Entry 50033188: C20-trifluoro-5-oxo-ETE: a metabolically stable 5-oxo-ETE derivative.

description: Small molecule binding data for protein TG 1019, Uniprot Q8TDS5
DOI: 10.7270/q20p109x
title: BindingDB Entry 50033205: Discovery of 6-(2,4-difluorophenoxy)-2-[3-hydroxy-1-(2-hydroxyethyl)propylamino]-8-methyl-8H-pyrido[2,3-d]pyrimidin-7-one (pamapimod) and 6-(2,4-difluorophenoxy)-8-methyl-2-(tetrahydro-2H-pyran-4-ylamino)pyrido[2,3-d]pyrimidin-7(8H)-one (R1487) as orally bioavailable and highly selective inhibitors

description: Small molecule binding data for protein Casein kinase I delta/epsilon, Chaperone activity of bc1 complex-like, mitochondrial, Cytochrome P450 1A, Cytochrome P450 2C19, Cytochrome P450 2C9, Cytochrome P450 2D6 (2D6), Cytochrome P450 3A, Epithelial discoidin domain-containing receptor 1, MAP kinase p38, Mitogen-activated protein kinase 10, Mitogen-activated protein kinase 14, Mitogen-activated protein kinase 9, Ribosomal protein S6 kinase alpha 3, Ribosomal protein S6 kinase alpha 4, SRC, Serine/threonine protein kinase NLK, Serine/threonine-protein kinase 36, Serine/threonine-protein kinase GAK, and c-Jun N-terminal kinase, JNK, Uniprot O14976, O75676, P05177, P06239, P08684, P10635, P11712, P33261, P45983, P45984, P49674, P51812, P53779, Q08345, Q15759, Q16539, Q8NI60, Q9NRP7, and Q9UBE8
DOI: 10.21258/1354766
title: Swiss national forest inventory - Result table No. 126287
DOI: 10.21258/1354767
title: Swiss national forest inventory - Result table No. 126278
DOI: 10.21258/1354768
title: Swiss national forest inventory - Result table No. 126280
DOI: 10.21258/1354769
title: Swiss national forest inventory - Result table No. 126279
DOI: 10.21258/1354761
title: Swiss national forest inventory - Result table No. 126291
DOI: 10.21258/1354762
title: Swiss national forest inventory - Result table No. 126290
DOI: 10.21258/1354763
title: Swiss national forest inventory - Result table No. 126289
DOI: 10.21258/1354764
title: Swiss national forest inventory - Result table No. 126288
DOI: 10.21258/1354765
title: Swiss national forest inventory - Result table No. 126286
DOI: 10.21258/1354756
title: Swiss national forest inventory - Result table No. 126309
DOI: 10.21258/1354757
title: Swiss national forest inventory - Result table No. 126310
DOI: 10.21258/1354758
title: Swiss national forest inventory - Result table No. 126312
DOI: 10.21258/1354759
title: Swiss national forest inventory - Result table No. 126308
DOI: 10.21258/1354760
title: Swiss national forest inventory - Result table No. 126307
DOI: 10.21258/1354751
title: Swiss national forest inventory - Result table No. 126330
DOI: 10.21258/1354752
title: Swiss national forest inventory - Result table No. 126329
DOI: 10.21258/1354753
title: Swiss national forest inventory - Result table No. 126328
DOI: 10.21258/1354754
title: Swiss national forest inventory - Result table No. 126331
DOI: 10.21258/1354755
title: Swiss national forest inventory - Result table No. 126311
DOI: 10.21258/1354746
title: Swiss national forest inventory - Result table No. 126338
DOI: 10.21258/1354747
title: Swiss national forest inventory - Result table No. 126334
DOI: 10.21258/1354748
title: Swiss national forest inventory - Result table No. 126333
DOI: 10.21258/1354749
title: Swiss national forest inventory - Result table No. 126332
DOI: 10.6084/m9.figshare.10073669.v1
title: Nanoparticles of Fe2O3 and Co3O4 as Efficient Electrocatalysts for Oxygen Reduction Reaction in Acid Medium

description: This paper presents a comparative study about the oxygen reduction reaction (ORR) catalyzed by nanoparticles of Fe2O3 and Co3O4 applied on the surface of glassy carbon electrodes (GCE). The nanoparticles were synthesized using the modified polymeric precursor method (Pechini). These two nanomaterials were characterized by Fourier transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD) techniques. The estimated average particle sizes were 21 and 31 nm for Fe2O3 and Co3O4, respectively. Electrochemical impedance spectroscopy (EIS) showed that Fe2O3/GCE has lower charge transfer resistance than Co3O4/GCE. The surface electrochemistry of both Fe2O3/GCE and Co3O4/GCE was studied in the solution free of O2, and their corresponding reaction mechanisms were analyzed. The electrocatalytic ORR activities of these two catalysts were studied by cyclic voltammetry (CV) and rotating disk electrode (RDE) in acidic solution. The results obtained by RDE indicated that both Fe2O3/GCE and Co3O4/GCE can catalyze the ORR with a dominating 2-electron transfer process to produce H2O2, using a potential of -0.8 V. These kinetic results indicate that Fe2O3/GCE is more efficient than Co3O4/GCE in terms of ORR. Considering the low cost of these two non-noble metal catalysts, they may be used as viable alternatives for ORR electrocatalysts.
DOI: 10.6084/m9.figshare.5355097
title: HCV+ Subjects 14.08.18.xlsx

description: We performed a retrospective study of HCV infection in a UK teaching hospital to evaluate and compare the performance of different laboratory tests, to describe the population with active HCV infection and to determine the proportion of these individuals who access clinical review and treatment. Microbiology records for all HCV screening tests performed at Oxford University Hospitals within two defined time-intervals (Group 1 - 18 months; Jan 2013 - June 2014, Group 2 - 15 months; Jan 2015 - March 2016) were studied . For those testing positive we collected follow-up testing data. We recorded patient age, sex, and the location from which the sample was sent. We used an analytical tool to estimate ethnicity applying Onolytics software for all patients whom a full name was part of the electronic record. Ethics approval was not required, as this study was undertaken as a departmental quality improvement exercise within microbiology using anonymised patient data, and completed the audit cycle for previously approved audit projects. Data for Onolytics analysis were handled separately and were subject to a confidential disclosure agreement drawn up by University of Oxford Research Services (February 2016). <br><br><br><br><br><br><br><br><br><br><br><br>
DOI: 10.6084/m9.figshare.14788504.v1
title: Additional file 1 of Antegrade intramedullary fixation for adolescent fifth metacarpal neck fracture and its impact on epiphyseal growth

description: Additional file 1.
DOI: 10.25549/usctheses-ouc11666684
title: Selective effects of 5-Bromodeoxyuridine on rat hepatoma tissue culture cells
DOI: 10.6084/m9.figshare.10073750
title: Fermentation characteristics and in vitro ruminal digestion of yacon residue silage with lactic acid bacteria inoculant or beet pulp

description: ABSTRACT In this study, we examined the effects of lactic acid bacteria (LAB) inoculant and beet pulp (BP) on the quality of yacon (Smallanthus sonchifolius) residue silage. Yacon silage was prepared using a small-scale system of silage fermentation, and the treatments were as follows: control silage without any additive and silages with LAB inoculant Chikuso-1 (Lactobacillus plantarum, 5 mg/kg, fresh matter basis), BP (30% fresh matter basis), and LAB+BP. Silages were opened on days 3, 5, 7, 15, 30, and 60 of fermentation. The chemical composition, organic acid content, and in vitro ruminal digestion of the 60-day silage were determined. The pH of LAB-treated silage was lower than that of the silage without LAB. Furthermore, the LAB-treated silage presented the lowest ammonia-N concentration among the four types of silages, and it inhibited the growth of harmful bacteria including molds and clostridia during the early stages of fermentation. The BP-treated silage had lower contents of crude protein and ether extract than the silage without BP. The 60-day silage inoculated with LAB had the highest in vitro dry matter (DM) digestibility among the four silages, and the production of methane was lower than that of the silage treated with BP. The pH showed a tendency toward stabilization after 30 days of fermentation, although the concentration of lactic acid exhibited fluctuations during fermentation. The results suggest that the addition of LAB and BP can improve the fermentation quality of yacon silage, and the yacon silage with LAB might increase in vitro DM digestibility, but decrease in vitro ruminal methane production.
DOI: 10.6084/m9.figshare.10073750.v1
title: Fermentation characteristics and in vitro ruminal digestion of yacon residue silage with lactic acid bacteria inoculant or beet pulp

description: ABSTRACT In this study, we examined the effects of lactic acid bacteria (LAB) inoculant and beet pulp (BP) on the quality of yacon (Smallanthus sonchifolius) residue silage. Yacon silage was prepared using a small-scale system of silage fermentation, and the treatments were as follows: control silage without any additive and silages with LAB inoculant Chikuso-1 (Lactobacillus plantarum, 5 mg/kg, fresh matter basis), BP (30% fresh matter basis), and LAB+BP. Silages were opened on days 3, 5, 7, 15, 30, and 60 of fermentation. The chemical composition, organic acid content, and in vitro ruminal digestion of the 60-day silage were determined. The pH of LAB-treated silage was lower than that of the silage without LAB. Furthermore, the LAB-treated silage presented the lowest ammonia-N concentration among the four types of silages, and it inhibited the growth of harmful bacteria including molds and clostridia during the early stages of fermentation. The BP-treated silage had lower contents of crude protein and ether extract than the silage without BP. The 60-day silage inoculated with LAB had the highest in vitro dry matter (DM) digestibility among the four silages, and the production of methane was lower than that of the silage treated with BP. The pH showed a tendency toward stabilization after 30 days of fermentation, although the concentration of lactic acid exhibited fluctuations during fermentation. The results suggest that the addition of LAB and BP can improve the fermentation quality of yacon silage, and the yacon silage with LAB might increase in vitro DM digestibility, but decrease in vitro ruminal methane production.
DOI: 10.6084/m9.figshare.10073798
title: The effects of the method and dose of cyclophosphamide administration on cashmere shedding

description: ABSTRACT The objective of this study was to investigate the effects of the method and dose of cyclophosphamide (CPA) administration on cashmere shedding. Thirty-two castrated Liaoning cashmere goats were randomly allotted to four groups, with eight replicates in each group. Goats in the four groups were injected intravenously or intramuscularly with CPA at doses of 20 or 25 mg kg−1 body weight (BW), respectively. Feed intake and BW were recorded, and erythrocyte count, hemoglobin content, and cashmere weight were determined. It was found that the CPA administration method had no significant effect on feed intake or BW of cashmere goats. Cyclophosphamide injection can significantly decrease the erythrocyte count and hemoglobin content of cashmere goats, but the effects are dependent on injection method and CPA dose. The injection method and dose did not significantly influence cashmere weight, but the method had significant effects on time to initiate shedding and regrown hair length. Regrown hair was longest by intramuscular injection with 20 mg kg−1 BW, which also caused the least erythema on the epidermis during the days after shedding. The results indicate that the CPA administration method can significantly influence cashmere shedding. Intramuscular injection of CPA at a dose of 20 mg kg−1 BW was found to be relatively beneficial for hair removal and regrowth in cashmere goats.
DOI: 10.6084/m9.figshare.10073798.v1
title: The effects of the method and dose of cyclophosphamide administration on cashmere shedding

description: ABSTRACT The objective of this study was to investigate the effects of the method and dose of cyclophosphamide (CPA) administration on cashmere shedding. Thirty-two castrated Liaoning cashmere goats were randomly allotted to four groups, with eight replicates in each group. Goats in the four groups were injected intravenously or intramuscularly with CPA at doses of 20 or 25 mg kg−1 body weight (BW), respectively. Feed intake and BW were recorded, and erythrocyte count, hemoglobin content, and cashmere weight were determined. It was found that the CPA administration method had no significant effect on feed intake or BW of cashmere goats. Cyclophosphamide injection can significantly decrease the erythrocyte count and hemoglobin content of cashmere goats, but the effects are dependent on injection method and CPA dose. The injection method and dose did not significantly influence cashmere weight, but the method had significant effects on time to initiate shedding and regrown hair length. Regrown hair was longest by intramuscular injection with 20 mg kg−1 BW, which also caused the least erythema on the epidermis during the days after shedding. The results indicate that the CPA administration method can significantly influence cashmere shedding. Intramuscular injection of CPA at a dose of 20 mg kg−1 BW was found to be relatively beneficial for hair removal and regrowth in cashmere goats.
DOI: 10.6084/m9.figshare.10073939
title: Incidence of cystoid macular edema following routine cataract surgery using NSAIDs alone or with corticosteroids

description: ABSTRACT Purpose: To evaluate the rate of cystoid macular edema development among cataract surgery patients on four different therapeutic regimens. Methods: The present study is a retrospective analysis of 5,380 eyes following uncomplicated phacoemulsification at Wake Forest University. The study period went from July 2007 to December 2012. Patients received one of four regimens, as follows: postoperative generic ketorolac 0.4% and prednisolone 1%, postoperative name-brand ketorolac 0.45% and prednisolone 1%, postoperative bromfenac 0.09% and prednisolone 1%, preoperative and postoperative bromfenac 0.09% alone. A statistical analysis was performed to assess the differences in rate of cystoid macular edema development among the four different therapeutic regimens. The diagnosis of cystoid macular edema required worsening of vision and evidence of increased macular thickness on optical coherence tomography. Results: The overall rate of cystoid macular edema was 0.82%. Treatment by postoperative generic ketorolac 0.45% and prednisolone 1% demonstrated the highest rate of cystoid macular edema development (2.20% of the cases). Postoperative name-brand ketorolac 0.45% and prednisolone 1% exhibited intermediate rates of cystoid macular edema development (0.90% of the cases). Postoperative administration of bromfenac 0.09% and prednisolone 1% exhibited intermediate rates of cystoid macular edema development (0.44% of the cases). Preoperative and postoperative bromfenac 0.09% alone resulted in the lowest rate of cystoid macular edema development (0.09% of the cases). The rate of cystoid macular edema was significantly lower when bromfenac was used alone vs. either regimen where ketorolac and prednisolone were used (OR 0.043, 95% CI 0.002 to 0.312; p&lt;0.001). Conclusions: Post-cataract surgery cystoid macular edema developed less frequently following topical non-steroidal anti-inflammatory drugs regimen compared to the other therapies evaluated. Bromfenac, without corticosteroids, achieved lower rates of cystoid macular edema vs. various combinations of non-steroidal anti-inflammatory drugs with corticosteroids.