cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.6125294
title: Influence of polymorphisms of the beta-2 adrenergic receptor on the presence of exercise-induced bronchospasm in adolescents

description: Abstract Objective: To determine the influence of polymorphisms of the beta-2 adrenergic receptor (ADRB2) in triggering exercise-induced bronchospasm (EIB) in adolescents. Methods: The subjects were divided into two groups: present EIB (EIB+) (n=45) and absent EIB (EIB−) (n=115). The bronchial provocation test with exercise was performed with a protocol that consisted of walking/running for at least eight minutes at high intensity, i.e., &gt;85% of maximum heart rate, considering EIB+ as a 10% decrease in forced expiratory volume in one second (FEV1). The genotyping of the ADRB2 gene was performed by the Taqman method, using the Step One Plus system. Independent t-test, Mann–Whitney and Chi-square tests, as well as Spearman's correlation coefficient were used for the statistical analysis. Results: Age, body weight, height, FEV1, FVC and FEV1/FVC ratio were lower in the EIB+ group when compared to EIB− (p&lt;0.05). There were no significant differences in the proportion of the allele at position 27 and Arg16Gly and Gln27Glu genotypes between the EIB+ and EIB− groups (p=0.26; p=0.97 and p=0.43, respectively). However, there was a trend toward statistical significance regarding the greater proportion of the Gly16 allele for the EIB+ when compared to the EIB− group (p=0.08). Conclusions: The presence of polymorphisms associated with the Glu27 allele and Arg16Gly and Gln27Glu genotypes had no influence on EIB. However, the statistical trend toward greater frequency of the Gly16 allele in individuals with EIB+ can be considered evidence of the influence of polymorphisms of the ADBR2 gene on EIB in adolescents.
DOI: 10.6084/m9.figshare.6125294.v1
title: Influence of polymorphisms of the beta-2 adrenergic receptor on the presence of exercise-induced bronchospasm in adolescents

description: Abstract Objective: To determine the influence of polymorphisms of the beta-2 adrenergic receptor (ADRB2) in triggering exercise-induced bronchospasm (EIB) in adolescents. Methods: The subjects were divided into two groups: present EIB (EIB+) (n=45) and absent EIB (EIB−) (n=115). The bronchial provocation test with exercise was performed with a protocol that consisted of walking/running for at least eight minutes at high intensity, i.e., &gt;85% of maximum heart rate, considering EIB+ as a 10% decrease in forced expiratory volume in one second (FEV1). The genotyping of the ADRB2 gene was performed by the Taqman method, using the Step One Plus system. Independent t-test, Mann–Whitney and Chi-square tests, as well as Spearman's correlation coefficient were used for the statistical analysis. Results: Age, body weight, height, FEV1, FVC and FEV1/FVC ratio were lower in the EIB+ group when compared to EIB− (p&lt;0.05). There were no significant differences in the proportion of the allele at position 27 and Arg16Gly and Gln27Glu genotypes between the EIB+ and EIB− groups (p=0.26; p=0.97 and p=0.43, respectively). However, there was a trend toward statistical significance regarding the greater proportion of the Gly16 allele for the EIB+ when compared to the EIB− group (p=0.08). Conclusions: The presence of polymorphisms associated with the Glu27 allele and Arg16Gly and Gln27Glu genotypes had no influence on EIB. However, the statistical trend toward greater frequency of the Gly16 allele in individuals with EIB+ can be considered evidence of the influence of polymorphisms of the ADBR2 gene on EIB in adolescents.
DOI: 10.6084/m9.figshare.6125291
title: The effect of periodontal therapy on neopterin and vascular cell adhesion molecule-1 levels in chronic periodontitis patients with and without acute myocardial infarction: a case-control study

description: Abstract The presence of neopterin in gingival crevicular fluid (GCF) is a marker for local and acute immune activation, and the presence of vascular cell adhesion molecule (VCAM-1) in GCF is accepted as a marker for chronic vascular inflammation. Objectives This study aimed to evaluate effects of periodontal treatment on GCF levels of neopterin and VCAM-1 in patients with chronic periodontitis (CP) with acute myocardial infarction (AMI) compared with systemically healthy CP patients. Material and methods Sixty subjects (20 CP patients with AMI, 20 healthy CP patients, and 20 healthy controls) were included. GCF samples were analyzed at baseline and after 3 and 6 months, and the probing pocket depth (PD), clinical attachment level (CAL), bleeding on probing, gingival (GI) and plaque (PI) indices were recorded. We determined neopterin and VCAM-1 levels (concentration and total amount) using enzyme-linked immunosorbent assay (ELISA). No significant differences were seen between the AMI+CP and CP groups for PI, GI, GCF levels of neopterin and VCAM-1 at baseline. Results The number of teeth with 5 mm≤CAL&lt;7 mm and CAL≥7 mm were significantly increased in the AMI+CP group at baseline. There were no significant differences between the AMI+CP and CP for PI, CAL, GCF volumes, and the AMI+CP group had the highest clinical improvement in the number of teeth with 5 mm≤CAL&lt;7 mm at the sixth month. There were significant positive correlations between clinical periodontal inflammation and the presence of neopterin and VCAM-1 in GCF prior to and following periodontal treatment, and between the GCF volume and clinical parameters. Conclusions Data suggest that the total amount and concentration of neopterin and VCAM-1 in GCF seemed to be closely associated with periodontal disease severity in CP patients with AMI. Moreover, the results of our study demonstrate that the past periodontal status is potentially correlated between groups, with similar periodontal disease severity.
DOI: 10.6084/m9.figshare.6125291.v1
title: The effect of periodontal therapy on neopterin and vascular cell adhesion molecule-1 levels in chronic periodontitis patients with and without acute myocardial infarction: a case-control study

description: Abstract The presence of neopterin in gingival crevicular fluid (GCF) is a marker for local and acute immune activation, and the presence of vascular cell adhesion molecule (VCAM-1) in GCF is accepted as a marker for chronic vascular inflammation. Objectives This study aimed to evaluate effects of periodontal treatment on GCF levels of neopterin and VCAM-1 in patients with chronic periodontitis (CP) with acute myocardial infarction (AMI) compared with systemically healthy CP patients. Material and methods Sixty subjects (20 CP patients with AMI, 20 healthy CP patients, and 20 healthy controls) were included. GCF samples were analyzed at baseline and after 3 and 6 months, and the probing pocket depth (PD), clinical attachment level (CAL), bleeding on probing, gingival (GI) and plaque (PI) indices were recorded. We determined neopterin and VCAM-1 levels (concentration and total amount) using enzyme-linked immunosorbent assay (ELISA). No significant differences were seen between the AMI+CP and CP groups for PI, GI, GCF levels of neopterin and VCAM-1 at baseline. Results The number of teeth with 5 mm≤CAL&lt;7 mm and CAL≥7 mm were significantly increased in the AMI+CP group at baseline. There were no significant differences between the AMI+CP and CP for PI, CAL, GCF volumes, and the AMI+CP group had the highest clinical improvement in the number of teeth with 5 mm≤CAL&lt;7 mm at the sixth month. There were significant positive correlations between clinical periodontal inflammation and the presence of neopterin and VCAM-1 in GCF prior to and following periodontal treatment, and between the GCF volume and clinical parameters. Conclusions Data suggest that the total amount and concentration of neopterin and VCAM-1 in GCF seemed to be closely associated with periodontal disease severity in CP patients with AMI. Moreover, the results of our study demonstrate that the past periodontal status is potentially correlated between groups, with similar periodontal disease severity.
DOI: 10.6084/m9.figshare.6125288
title: Amino acid composition, and determination and prediction of the protein digestibility of different sugarcane yeasts in broilers

description: ABSTRACT The aim of this study was to determine the amino acid composition and digestible protein values of different sugarcane yeasts, as well as to generate prediction equations for the apparent digestibility coefficient of dry matter (ADCDM) and crude protein (ADCCP), based on the chemical composition of the yeast and the age of the broilers. Four ileal digestion trials were carried out with 690 broilers, divided into the pre-starter, starter, growth and final phases. The birds were housed in metabolic cages and distributed in a completely randomised design, consisting of five treatments and six replications of eight, six, five and four birds respectively in each experimental phase. The treatments consisted of one reference feed and four test feeds, substituting 30% of the reference feed with four different yeasts. Yeasts two and four showed a higher percentage of amino acids. However, yeast two had the highest percentages of ADCDM, ADCCP and digestible protein: 83.64, 81.22 and 14.66% in the pre-starter phase; 78.09, 78.28 and 14.13% in the starter phase; 76.74, 74.75 and 13.49% in the growth phase; and 72.98, 71.21 and 12.85% in the final phase respectively. There was an average reduction of 0.424% in ADCDM and 0.428% in ADCCP for each day the birds aged. The following prediction equations were generated from the composition of the yeasts and age of the chickens: ADCDM = 77.4 - 0.424*(age) - 7.51*(DM) - 45.01*(EE) and - 0.424*(age) + 3.02*(CP) + 126.93*(EE) - 0.03*(GMD) and ADCCP = 606.9-0.428*(age) -5.8*(DM) - 0.01*(GMD) and -0.426*(age) + 2.68(CP) + 139.7*(EE) - 0.03*(GMD).
DOI: 10.6084/m9.figshare.6125288.v1
title: Amino acid composition, and determination and prediction of the protein digestibility of different sugarcane yeasts in broilers

description: ABSTRACT The aim of this study was to determine the amino acid composition and digestible protein values of different sugarcane yeasts, as well as to generate prediction equations for the apparent digestibility coefficient of dry matter (ADCDM) and crude protein (ADCCP), based on the chemical composition of the yeast and the age of the broilers. Four ileal digestion trials were carried out with 690 broilers, divided into the pre-starter, starter, growth and final phases. The birds were housed in metabolic cages and distributed in a completely randomised design, consisting of five treatments and six replications of eight, six, five and four birds respectively in each experimental phase. The treatments consisted of one reference feed and four test feeds, substituting 30% of the reference feed with four different yeasts. Yeasts two and four showed a higher percentage of amino acids. However, yeast two had the highest percentages of ADCDM, ADCCP and digestible protein: 83.64, 81.22 and 14.66% in the pre-starter phase; 78.09, 78.28 and 14.13% in the starter phase; 76.74, 74.75 and 13.49% in the growth phase; and 72.98, 71.21 and 12.85% in the final phase respectively. There was an average reduction of 0.424% in ADCDM and 0.428% in ADCCP for each day the birds aged. The following prediction equations were generated from the composition of the yeasts and age of the chickens: ADCDM = 77.4 - 0.424*(age) - 7.51*(DM) - 45.01*(EE) and - 0.424*(age) + 3.02*(CP) + 126.93*(EE) - 0.03*(GMD) and ADCCP = 606.9-0.428*(age) -5.8*(DM) - 0.01*(GMD) and -0.426*(age) + 2.68(CP) + 139.7*(EE) - 0.03*(GMD).
DOI: 10.6084/m9.figshare.6125285
title: The impact of nonsyndromic cleft lip with or without cleft palate on oral health-related quality of life

description: Abstract Nonsyndromic cleft lip with or without cleft palate (NSCL±P) compromises oral health, leading to missing or malformed teeth, and hampering oral hygiene. Apart from anatomic damages, NSCL±P also culminates in an impact on the routine quality of life with social privation and psychological embarrassment. Objective To evaluate the impact of NSCL±P on oral health-related quality of life. Material and Methods The study was classified as exploratory and descriptive, with quantitative approach. Patients with NSCL±P treated between August 2013 and September 2014 at the Cleft Lip and Palate Integral Care Center (CAIF), Curitiba, Brazil, were invited to participate. Age and sex-related data were collected, as well as level of education, financial income, type of orofacial cleft, use of orthodontic and prosthetic appliances, and number of previous orofacial surgeries. Selected patients were asked to answer the Oral Impact on Daily Performance (OIDP) questionnaire designed to measure the impact of oral health on daily performances. Results The sample was composed of 103 (44.59%) women and 128 (55.41%) men, with mean age of 19.74 ± 10.20 (7–65) years. The OIDP values ranged from 1 to 175 in 114 (49.35%) patients (mean: 22.38), whereas 117 patients (50.65%) presented total OIDP value equal to zero. High negative impact of NSCL±P on daily performances was detected when associated with the female sex (p=0.037). Daily performances related to phonetics (OIDP2; 2.63) and aesthetics (OIDP5; 2.48) presented the highest average values when compared to other daily performances, except OIDP6. The main symptoms and reported oral problems comprised the aesthetic dissatisfaction. Conclusions Almost half of the patients evaluated in this study showed negative impact of NSCL±P in the performance of daily activities.
DOI: 10.6084/m9.figshare.6125285.v1
title: The impact of nonsyndromic cleft lip with or without cleft palate on oral health-related quality of life

description: Abstract Nonsyndromic cleft lip with or without cleft palate (NSCL±P) compromises oral health, leading to missing or malformed teeth, and hampering oral hygiene. Apart from anatomic damages, NSCL±P also culminates in an impact on the routine quality of life with social privation and psychological embarrassment. Objective To evaluate the impact of NSCL±P on oral health-related quality of life. Material and Methods The study was classified as exploratory and descriptive, with quantitative approach. Patients with NSCL±P treated between August 2013 and September 2014 at the Cleft Lip and Palate Integral Care Center (CAIF), Curitiba, Brazil, were invited to participate. Age and sex-related data were collected, as well as level of education, financial income, type of orofacial cleft, use of orthodontic and prosthetic appliances, and number of previous orofacial surgeries. Selected patients were asked to answer the Oral Impact on Daily Performance (OIDP) questionnaire designed to measure the impact of oral health on daily performances. Results The sample was composed of 103 (44.59%) women and 128 (55.41%) men, with mean age of 19.74 ± 10.20 (7–65) years. The OIDP values ranged from 1 to 175 in 114 (49.35%) patients (mean: 22.38), whereas 117 patients (50.65%) presented total OIDP value equal to zero. High negative impact of NSCL±P on daily performances was detected when associated with the female sex (p=0.037). Daily performances related to phonetics (OIDP2; 2.63) and aesthetics (OIDP5; 2.48) presented the highest average values when compared to other daily performances, except OIDP6. The main symptoms and reported oral problems comprised the aesthetic dissatisfaction. Conclusions Almost half of the patients evaluated in this study showed negative impact of NSCL±P in the performance of daily activities.
DOI: 10.6084/m9.figshare.6125279
title: Growth, water consumption and mineral composition of watercress under hydroponic system with brackish water

description: ABSTRACT The underground water reserves in the semi-arid region present high salinity levels. However, the scarcity of the resource compels the use of this water for several human activities, including agriculture. The aim of this work was to evaluate the use of brackish water for watercress cultivation (Nasturtium officinale) in a hydroponic NFT system (laminar flow of nutrients) and effects on water consumption, growth, yield and nutrient extraction by the plant. We studied six levels of salinity (0.2; 1.2; 2.2; 3.2; 4.2 and 5.2 dS m-1), in a completely randomized experimental design, with four replicates. Salinity was obtained by the addition of NaCl into the local water supply, being these waters used to prepare the nutrient solution and to replace the evapotranspirated water volume. We noticed a reduction in leaf area, fresh and dry mass of shoot, K content in plant and water consumption of the crop and, increased contents of P, Na, Cl in the plants, with increasing salinity of the solution. The use of brackish water for watercress cultivation in hydroponics is possible as an alternative for producers who have availability of brackish water and restricted possibility of fresh water. A reduction in dry mass of plants was observed with increasing electrical conductivity.
DOI: 10.6084/m9.figshare.6125279.v1
title: Growth, water consumption and mineral composition of watercress under hydroponic system with brackish water

description: ABSTRACT The underground water reserves in the semi-arid region present high salinity levels. However, the scarcity of the resource compels the use of this water for several human activities, including agriculture. The aim of this work was to evaluate the use of brackish water for watercress cultivation (Nasturtium officinale) in a hydroponic NFT system (laminar flow of nutrients) and effects on water consumption, growth, yield and nutrient extraction by the plant. We studied six levels of salinity (0.2; 1.2; 2.2; 3.2; 4.2 and 5.2 dS m-1), in a completely randomized experimental design, with four replicates. Salinity was obtained by the addition of NaCl into the local water supply, being these waters used to prepare the nutrient solution and to replace the evapotranspirated water volume. We noticed a reduction in leaf area, fresh and dry mass of shoot, K content in plant and water consumption of the crop and, increased contents of P, Na, Cl in the plants, with increasing salinity of the solution. The use of brackish water for watercress cultivation in hydroponics is possible as an alternative for producers who have availability of brackish water and restricted possibility of fresh water. A reduction in dry mass of plants was observed with increasing electrical conductivity.
DOI: 10.6084/m9.figshare.6125273
title: Physiology and postharvest conservation of ‘Paluma’ guava under coatings using Jack fruit seed-based starch

description: Abstract The aim of this work was to evaluate the effect of jackfruit seed starch-based (S) coatings, added to chitosan and alginate on the physiology and maintenance of quality of cold stored ‘Paluma’ guavas, followed by transfer to the room condition. The design was the completely randomized, in a 4x2 factorial scheme, in 4 replications, with 4 coatings (dispersion of S - 4%; S 2% + chitosan - 2% (SC); S - 2% + alginate - 2% (SA); and the uncoated control), in 2 environments (refrigerated (10±2 °C e 80±2% RH) with transfer to room condition (25±3 °C e 75±4% HR)), on the 16th and 20th day of cold storage. The SC and SA coatings were efficient in reducing the respiratory rate in fruits during 10 days at room condition. The SC coating delayed fruit ripening, and maintained firmness and color, with intention of purchasing and appearance higher than the limit of acceptance for another 6 days, following transferring to room condition, at the 16th day of refrigeration.
DOI: 10.6084/m9.figshare.6125273.v1
title: Physiology and postharvest conservation of ‘Paluma’ guava under coatings using Jack fruit seed-based starch

description: Abstract The aim of this work was to evaluate the effect of jackfruit seed starch-based (S) coatings, added to chitosan and alginate on the physiology and maintenance of quality of cold stored ‘Paluma’ guavas, followed by transfer to the room condition. The design was the completely randomized, in a 4x2 factorial scheme, in 4 replications, with 4 coatings (dispersion of S - 4%; S 2% + chitosan - 2% (SC); S - 2% + alginate - 2% (SA); and the uncoated control), in 2 environments (refrigerated (10±2 °C e 80±2% RH) with transfer to room condition (25±3 °C e 75±4% HR)), on the 16th and 20th day of cold storage. The SC and SA coatings were efficient in reducing the respiratory rate in fruits during 10 days at room condition. The SC coating delayed fruit ripening, and maintained firmness and color, with intention of purchasing and appearance higher than the limit of acceptance for another 6 days, following transferring to room condition, at the 16th day of refrigeration.
DOI: 10.6084/m9.figshare.6125267
title: Association between TNFα - 308 G/A polymorphism and oral lichen planus (OLP): a meta-analysis

description: Abstract Objectives To determine whether Tumor Necrosis Factor alpha (TNFα) –308 G/A polymorphism is associated with oral lichen planus (OLP). Material and Methods A systematic electronic search of the literature was conducted to identify all published studies on the association between TNFα –308 G/A polymorphism and OLP. All case-control studies evaluating the TNFα –308 G/A polymorphisms in OLP were selected. A meta-analysis of the studies that fulfilled the inclusion criteria was performed. Odds ratios (OR) with 95% confidence intervals (CI) were also calculated. Results Seven studies comprising 450 OLP cases and 867 controls were included in the meta-analysis. In the pooled analysis, TNFα –308 G/A polymorphism was associated with OLP with random effects and OR of 2.33 (95%CI=1.07-5.11; p=0.03), assuming a dominant mode of inheritance (AA+GA vs. GG). In the subgroup analysis by ethnicity, TNFα –308 G/A was associated with a significantly increased odds ratio of OLP in mixed ethnicity (OR=5.22; 95%CI=1.93-14.15; p=0.001), but not in Asians (OR=1.57; 95%CI=0.54-4.54; p=0.41) or Caucasians (OR=1.45; 95%CI=0.19-11.22; p=0.72). For subgroup analysis based on HCV (hepatitis C virus) infection status, significant increased risk of OLP was found among patients with mixed HCV infection status (OR=3.77; 95%CI=1.07-13.2; p=0.038), but not in patients without HCV infection (OR=2.09; 95%CI=0.63-6.91; p=0.22) and patients with HCV infection (OR=0.48; 95%CI=0.13-1.69; p=0.25). Conclusion Our results suggest that –308 G/A polymorphism in TNFα is a potential genetic marker for OLP.
DOI: 10.6084/m9.figshare.6125267.v1
title: Association between TNFα - 308 G/A polymorphism and oral lichen planus (OLP): a meta-analysis

description: Abstract Objectives To determine whether Tumor Necrosis Factor alpha (TNFα) –308 G/A polymorphism is associated with oral lichen planus (OLP). Material and Methods A systematic electronic search of the literature was conducted to identify all published studies on the association between TNFα –308 G/A polymorphism and OLP. All case-control studies evaluating the TNFα –308 G/A polymorphisms in OLP were selected. A meta-analysis of the studies that fulfilled the inclusion criteria was performed. Odds ratios (OR) with 95% confidence intervals (CI) were also calculated. Results Seven studies comprising 450 OLP cases and 867 controls were included in the meta-analysis. In the pooled analysis, TNFα –308 G/A polymorphism was associated with OLP with random effects and OR of 2.33 (95%CI=1.07-5.11; p=0.03), assuming a dominant mode of inheritance (AA+GA vs. GG). In the subgroup analysis by ethnicity, TNFα –308 G/A was associated with a significantly increased odds ratio of OLP in mixed ethnicity (OR=5.22; 95%CI=1.93-14.15; p=0.001), but not in Asians (OR=1.57; 95%CI=0.54-4.54; p=0.41) or Caucasians (OR=1.45; 95%CI=0.19-11.22; p=0.72). For subgroup analysis based on HCV (hepatitis C virus) infection status, significant increased risk of OLP was found among patients with mixed HCV infection status (OR=3.77; 95%CI=1.07-13.2; p=0.038), but not in patients without HCV infection (OR=2.09; 95%CI=0.63-6.91; p=0.22) and patients with HCV infection (OR=0.48; 95%CI=0.13-1.69; p=0.25). Conclusion Our results suggest that –308 G/A polymorphism in TNFα is a potential genetic marker for OLP.