DOI: 10.5281/zenodo.10666764
title: Data of study "Lateral septum neurons that disable sociability in an autism mouse model

description: Data of study  "Lateral septum neurons that disable sociability in an autism mouse model"


 


Authors: Borie and colleagues


contact information


freddy.jeanneteau@igf.cnrs.fr


Orcid 0000-0002-9606-2892


institut de genomique fonctionnelle


141 rue de la Cardonille 


34090 Montpellier


France


 


 


Description of data presented by main figures


 


***Calcium activity in SST neurons of LS during social behavor Figure 1D***


data of photometry


 


 


***Area under spikes of knockout model Figure 1E***


data of in vivo photometry


 


 


***Spike duration of knockout model Figure 1F***


data of in vivo photometry


 


 


***Proportion of SST neurons in LS expressing c-FOS in Magel2 KO mice Figure 1G***


data of histology


 


 


***Optogenetic inhibition of SST neurons in LS of knockout model restored social discrimination Figure 1I***


data of mouse behavior


 


 


*** Injection of SSTR antagonist in LS of knockout model restored social discrimination Figure 1K***


data of mouse behavior


 


 


***Injection of SST in LS of WT mice restored social discrimination Figure 1L***


data of mouse behavior


 


 


***Proportion of SST neurons in LS expressing OXTR in Magel2 KO mice Figure 2B***


data of histology


 


 


***Density of SST neurons in LS of Magel2 KO mice Figure 2C***


data of histology


 


 


***Frequency of action potential in LS neurons inhibited by AVP then TGOT in WT mice Figure 2E***


data of electrophysiology ex vivo


 


 


***Frequency of action potential in LS neurons inhibited by AVP and TGOT in Magel2KO mice Figure 2F***


data of electrophysiology ex vivo


 


 


***Proportion of SST neurons insensitive to AVP and TGOT Figure 2G***


data of histology


 


 


***Frequency of action potential in LS neurons inhibited by AVP with GABAzine  Figure 2J***


data of electrophysiology ex vivo


 


 


***Frequency of action potential in LS neurons inhibited by TGOT  with GABAzine Figure 2K***


data of electrophysiology ex vivo


 


 


***Pharmacological inhibition of AVPR and OXTR during social novelty in Magel2 WT mice Figure 3A***


data of mouse behavior


 


 


***Effect of inhibitors injected during social novelty on the proportion of SST neurons with cFOS after social discrimination Figure 3C***


data of histology


 


 


***Pharmacological inhibition of AVPR and OXTR during social habituation in Magel2 WT mice Figure 3D***


data of mouse behavior


 


 


***Effect of inhibitors injected during social habituation on the proportion of SST neurons with cFOS after social discrimination Figure 3F***


data of histology


 


 


***Co-injection of AVP with antagonist of AVPR and OXTR in Magel2 KO mice Figure 3G***


data of mouse behavior


 


 


***Area under spikes in OXT neurons of PVN of WT mice Figure 4C***


data of in vivo photometry


 


 


***Proportion of OXT neurons in PVN expressing c-FOS in Magel2 KO mice Figure 4E***


data of histology


 


 


***Area under spikes in AVP neurons of PVN of WT mice Figure 4H***


data of in vivo photometry


 


 


***Proportion of AVP neurons in PVN expressing c-FOS in Magel2 KO mice Figure 4J***


data of histology


 


 


***Optogenetic inhibition of oxytocinergic or vasopressinergic PVN-LS pathways in Avp-CRE or OXT-Cre mice Figure 5B***


data of mouse behavior


 


 


***Optogenetic inhibition of oxytocinergic or vasopressinergic SON-LS pathways in Avp-CRE or OXT-Cre mice Figure 5D***


data of mouse behavior


 


 


***Optogenetic activation of oxytocinergic or vasopressinergic PVN-LS pathways in Magel2 KO;Avp-CRE or Magel2 KO;OXT-Cre double transgenic mice Figure 5F***


data of mouse behavior


 


 


***Optogenetic activation of oxytocinergic or vasopressinergic SON-LS pathways in Magel2 KO;Avp-CRE or Magel2 KO;OXT-Cre double transgenic mice Figure 5H***


data of mouse behavior