cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.7583084.v1
title: Diastereoselective synthesis of diverse 3,2′-pyrrolidinyl bispirooxindoles via 1,3-dipolar cycloaddition reactions of azomethine ylides with exocyclic α,β-unsaturated ketones and <i>in silico</i> studies for prediction of bioactivity

description: A three-component highly regio- and diastereoselective 1,3-dipolar cycloaddition reaction between isatin, a series of primary amino acids (10 nos), and exocyclic α,β-unsaturated ketones was developed towards the synthesis of a small library of bispirooxindole (20 nos) at ambient temperature. The developed reaction afforded highly substituted 3,2′-pyrrolidine-bispirooxindole with two vicinal spiro-quaternary and four contiguous stereocenters from the cheap and abundant starting materials. The products were obtained with good to excellent yields (50-95%) and as a single diastereoisomer in the majority of the cases. Primary amino acids were served as amine component for the <i>in-situ</i> generation of azomethine ylides from isatin. Molecular docking studies were carried out to explore the synthesized bispirooxindoles as inhibitors of the epidermal growth factor receptor (EGFR). Two compounds exhibited excellent binding affinity towards EGFR receptor.
DOI: 10.7284/123278
title: Meteorological Station data collected during research cruise FK160603 using a Gill MetPak Pro instrument system onboard the platform RV Falkor

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/123276
title: Splitbeam Echosounder data collected during research cruise FK160603 using a Kongsberg EK60 instrument system onboard the platform RV Falkor

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7583066
title: Investigation of activation mechanism and conformational stability of <i>N</i>-(4-chloro-3-trifluoromethyl-phenyl)-2-ethoxybenzamide and <i>N</i>-(4-chloro-3-trifluoromethyl-phenyl)-2-ethoxy-6-pentadecyl-benzamide in the: active site of p300 histone acetyl transferase enzyme by molecular dynamics and binding free energy studies

description: The CBP (CREB-binding protein) and p300 are related to transcriptional coactivator family and are involved in several post-translational modifications, in which the acetylation is an important factor because it commences the transcription process. Experimental studies report that CTPB (<i>N</i>-(4-chloro-3-trifluoromethyl-phenyl)-2-ethoxy-6-pentadecyl-benzamide) and CTB (<i>N</i>-(4-chloro-3-trifluoromethyl-phenyl)-2-ethoxybenzamide) are good activators of p300 HAT enzyme, but yet, the molecular mechanism of their activation is not explored. The present study pertains to determine the intermolecular interactions, stability and binding free energy of CTB and CTPB from the molecular docking, molecular dynamics (MD) simulation and binding free energy calculation. The docking studies of the molecules reveal that the docking score of CTPB (−15.64 kcal/mol) is higher than that of CTB (−12.30 kcal/mol); on the contrary, CTB forms a strong interaction with the key residues of catalytic site (Tyr1467 and Trp1436) compared with CTPB. The MD simulation shows the stability of both molecules in the active site of p300 and their interactions. Furthermore, both docking and MD simulation studies of CTB confirm that it forms expected key interactions and retain the interactions with the active site amino acid residues of p300 when compared with CTPB. For this reason, the CTB recruits more acetyl-CoA in the active site of p300 compared with CTPB; it leads to activate the acetylation process; hence, CTB may be a best activator than CTPB. The binding free energy value of CTPB (−24.79 ± 2.38 kcal/mol) is higher when compared with that of CTB (−12.14 ± 1.30 kcal/mol) molecule; perhaps, the interaction of pentadecyl chain of CTPB with p300, whereas in CTB, such a group is absent. Communicated by Ramaswamy H. Sarma
DOI: 10.6084/m9.figshare.7583066.v1
title: Investigation of activation mechanism and conformational stability of <i>N</i>-(4-chloro-3-trifluoromethyl-phenyl)-2-ethoxybenzamide and <i>N</i>-(4-chloro-3-trifluoromethyl-phenyl)-2-ethoxy-6-pentadecyl-benzamide in the: active site of p300 histone acetyl transferase enzyme by molecular dynamics and binding free energy studies

description: The CBP (CREB-binding protein) and p300 are related to transcriptional coactivator family and are involved in several post-translational modifications, in which the acetylation is an important factor because it commences the transcription process. Experimental studies report that CTPB (<i>N</i>-(4-chloro-3-trifluoromethyl-phenyl)-2-ethoxy-6-pentadecyl-benzamide) and CTB (<i>N</i>-(4-chloro-3-trifluoromethyl-phenyl)-2-ethoxybenzamide) are good activators of p300 HAT enzyme, but yet, the molecular mechanism of their activation is not explored. The present study pertains to determine the intermolecular interactions, stability and binding free energy of CTB and CTPB from the molecular docking, molecular dynamics (MD) simulation and binding free energy calculation. The docking studies of the molecules reveal that the docking score of CTPB (−15.64 kcal/mol) is higher than that of CTB (−12.30 kcal/mol); on the contrary, CTB forms a strong interaction with the key residues of catalytic site (Tyr1467 and Trp1436) compared with CTPB. The MD simulation shows the stability of both molecules in the active site of p300 and their interactions. Furthermore, both docking and MD simulation studies of CTB confirm that it forms expected key interactions and retain the interactions with the active site amino acid residues of p300 when compared with CTPB. For this reason, the CTB recruits more acetyl-CoA in the active site of p300 compared with CTPB; it leads to activate the acetylation process; hence, CTB may be a best activator than CTPB. The binding free energy value of CTPB (−24.79 ± 2.38 kcal/mol) is higher when compared with that of CTB (−12.14 ± 1.30 kcal/mol) molecule; perhaps, the interaction of pentadecyl chain of CTPB with p300, whereas in CTB, such a group is absent. Communicated by Ramaswamy H. Sarma
DOI: 10.7284/123279
title: SSV (Sound Speed Velocimeter) data collected during research cruise FK160603 using a Valeport MiniSVS instrument system onboard the platform RV Falkor

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7583054
title: ChIP-Seq of ZmSNAC1, ZmNAC23 and ZmNAC20

description: To explore the function of ZmSNAC1, ZmNAC23 and ZmNAC20 in salt stress resistance and plant development, the downstream target genes were explored by ChIP-Seq with ZmNACs-GFP transgenic maize plants (pooled leaves and roots at V1 stage).
DOI: 10.6084/m9.figshare.7583054.v1
title: ChIP-Seq of ZmSNAC1, ZmNAC23 and ZmNAC20

description: To explore the function of ZmSNAC1, ZmNAC23 and ZmNAC20 in salt stress resistance and plant development, the downstream target genes were explored by ChIP-Seq with ZmNACs-GFP transgenic maize plants (pooled leaves and roots at V1 stage).
DOI: 10.7284/123281
title: TSG (Thermosalinograph) data collected during research cruise FK160603 using a Sea-Bird SBE-45 instrument system onboard the platform RV Falkor

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7583051
title: MSB-18-8636_DatasetEV1.xlsx

description: All drug treatment conditions in Open TG-GATEs.<br>
DOI: 10.6084/m9.figshare.7583051.v1
title: MSB-18-8636_DatasetEV1

description: All drug treatment conditions in Open TG-GATEs.<br>
DOI: 10.7284/124023
title: GNSS (Global Navigation Satellite System) data collected during research cruise FK160623 using a C&C C-Nav 3050 instrument system onboard the platform RV Falkor

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/124022
title: Gyrocompass data collected during research cruise FK160623 using a Raytheon STD 22 instrument system onboard the platform RV Falkor

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/124027
title: INS (Inertial Navigation System) data collected during research cruise FK160623 using a Kongsberg Seapath 320 instrument system onboard the platform RV Falkor

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/124025
title: Meteorological Station data collected during research cruise FK160623 using a Gill MetPak Pro instrument system onboard the platform RV Falkor

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/124026
title: SSV (Sound Speed Velocimeter) data collected during research cruise FK160623 using a Valeport MiniSVS instrument system onboard the platform RV Falkor

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/124030
title: GNSS (Global Navigation Satellite System) data collected during research cruise FK160719 using a C&C C-Nav 3050 instrument system onboard the platform RV Falkor

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/124029
title: Gyrocompass data collected during research cruise FK160719 using a Raytheon STD 22 instrument system onboard the platform RV Falkor

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/124035
title: INS (Inertial Navigation System) data collected during research cruise FK160719 using a Kongsberg Seapath 320 instrument system onboard the platform RV Falkor

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/124033
title: Meteorological Station data collected during research cruise FK160719 using a Gill MetPak Pro instrument system onboard the platform RV Falkor

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/124032
title: Multibeam Echosounder data collected during research cruise FK160719 using a Kongsberg EM302 instrument system onboard the platform RV Falkor

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/124034
title: SSV (Sound Speed Velocimeter) data collected during research cruise FK160719 using a Valeport MiniSVS instrument system onboard the platform RV Falkor

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7582991
title: Additional file 6: of Genome-wide analysis of genetic predisposition to Alzheimerâ s disease and related sex disparities

description: Detailed information about the results from the Wald Ď 2 test to compare ORs of SNPs between males and females. (XLSX 107 kb)
DOI: 10.6084/m9.figshare.7582991.v1
title: Additional file 6: of Genome-wide analysis of genetic predisposition to Alzheimerâ s disease and related sex disparities

description: Detailed information about the results from the Wald Ď 2 test to compare ORs of SNPs between males and females. (XLSX 107 kb)
DOI: 10.7284/124039
title: Expendable Probe data collected during research cruise FK160823 using a Turo Quoll instrument system onboard the platform RV Falkor

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7582982
title: Additional file 5: of Genome-wide analysis of genetic predisposition to Alzheimerâ s disease and related sex disparities

description: Detailed information about the nominally AD-associated SNPs with the opposite pattern of significance in males and females. (XLSX 40 kb)
DOI: 10.6084/m9.figshare.7582982.v1
title: Additional file 5: of Genome-wide analysis of genetic predisposition to Alzheimerâ s disease and related sex disparities

description: Detailed information about the nominally AD-associated SNPs with the opposite pattern of significance in males and females. (XLSX 40 kb)
DOI: 10.7284/124040
title: Fluorometer data collected during research cruise FK160823 using a WET Labs ECO-FLNTU instrument system onboard the platform RV Falkor

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7582976
title: Additional file 4: of Genome-wide analysis of genetic predisposition to Alzheimerâ s disease and related sex disparities

description: Detailed information about the AD-associated SNPs under analysis plan 3 (only females). (XLSX 72 kb)
DOI: 10.6084/m9.figshare.7582976.v1
title: Additional file 4: of Genome-wide analysis of genetic predisposition to Alzheimerâ s disease and related sex disparities

description: Detailed information about the AD-associated SNPs under analysis plan 3 (only females). (XLSX 72 kb)
DOI: 10.7284/124038
title: GNSS (Global Navigation Satellite System) data collected during research cruise FK160823 using a C&C C-Nav 3050 instrument system onboard the platform RV Falkor

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7582967
title: Additional file 3: of Genome-wide analysis of genetic predisposition to Alzheimerâ s disease and related sex disparities

description: Detailed information about the AD-associated SNPs under analysis plan 2 (only males).Â (XLSX 57 kb)
DOI: 10.7284/124037
title: Gyrocompass data collected during research cruise FK160823 using a Raytheon STD 22 instrument system onboard the platform RV Falkor

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7582958
title: Additional file 2: of Genome-wide analysis of genetic predisposition to Alzheimerâ s disease and related sex disparities

description: Detailed information about the AD-associated SNPs under analysis plan 1 (males and females).Â (XLSX 72 kb)
DOI: 10.6084/m9.figshare.7582967.v1
title: Additional file 3: of Genome-wide analysis of genetic predisposition to Alzheimerâ s disease and related sex disparities

description: Detailed information about the AD-associated SNPs under analysis plan 2 (only males).Â (XLSX 57 kb)
DOI: 10.6084/m9.figshare.7582958.v1
title: Additional file 2: of Genome-wide analysis of genetic predisposition to Alzheimerâ s disease and related sex disparities

description: Detailed information about the AD-associated SNPs under analysis plan 1 (males and females).Â (XLSX 72 kb)
DOI: 10.7284/124044
title: INS (Inertial Navigation System) data collected during research cruise FK160823 using a Kongsberg Seapath 320 instrument system onboard the platform RV Falkor

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/124042
title: Meteorological Station data collected during research cruise FK160823 using a Gill MetPak Pro instrument system onboard the platform RV Falkor

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/124041
title: Multibeam Echosounder data collected during research cruise FK160823 using a Kongsberg EM302 instrument system onboard the platform RV Falkor

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/124043
title: SSV (Sound Speed Velocimeter) data collected during research cruise FK160823 using a Valeport MiniSVS instrument system onboard the platform RV Falkor

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/124045
title: TSG (Thermosalinograph) data collected during research cruise FK160823 using a Sea-Bird SBE-45 instrument system onboard the platform RV Falkor

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7582907
title: Temporal predictability does not impact attentional blink performance: Data and code

description: This is the full dataset and analysis code (in JAMOVI and R) for our paper on the topic of attentional blink performance with variable intervals between trials.
DOI: 10.7284/124048
title: ADCP (Acoustic Doppler Current Profiler) data collected during research cruise FK160924 using a Hawaii UHDAS instrument system onboard the platform RV Falkor

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/124049
title: Fluorometer data collected during research cruise FK160924 using a WET Labs ECO-FLNTU instrument system onboard the platform RV Falkor

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7582871
title: SI_Can habitat related ecosystem services promote migratory species conservation

description: ES data, shorebirds data, and expected value analysis
DOI: 10.6084/m9.figshare.7582871.v1
title: SI_Can habitat related ecosystem services promote migratory species conservation

description: ES data, shorebirds data, and expected value analysis
DOI: 10.7284/124047
title: GNSS (Global Navigation Satellite System) data collected during research cruise FK160924 using a C&C C-Nav 3050 instrument system onboard the platform RV Falkor

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/124046
title: Gyrocompass data collected during research cruise FK160924 using a Raytheon STD 22 instrument system onboard the platform RV Falkor

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/124052
title: INS (Inertial Navigation System) data collected during research cruise FK160924 using a Kongsberg Seapath 320 instrument system onboard the platform RV Falkor

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7582235
title: Characteristics of trunk and lower limb alignment at maximum reach during the Star Excursion Balance Test in subjects with increased knee valgus during jump landing

description: The results of knee, trunk, and hip angles of each subject in all reach directions during Star Excursion Balance Test.
DOI: 10.7284/124050
title: Meteorological Station data collected during research cruise FK160924 using a Gill MetPak Pro instrument system onboard the platform RV Falkor

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/124051
title: SSV (Sound Speed Velocimeter) data collected during research cruise FK160924 using a Valeport MiniSVS instrument system onboard the platform RV Falkor

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/124053
title: TSG (Thermosalinograph) data collected during research cruise FK160924 using a Sea-Bird SBE-45 instrument system onboard the platform RV Falkor

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/124016
title: ADCP (Acoustic Doppler Current Profiler) data collected during research cruise FK161010 using a Hawaii UHDAS instrument system onboard the platform RV Falkor

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/124013
title: CTD (Conductivity, Temperature, Depth) data collected during research cruise FK161010 using a Sea-Bird SBE-911+ instrument system onboard the platform RV Falkor

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/124015
title: Expendable Probe data collected during research cruise FK161010 using a Turo Quoll instrument system onboard the platform RV Falkor

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7582181
title: An improved high-quality genome assembly and annotation of Tibetan hulless barley

description: We reported an improved high-quality assembly of Tibetan hulless barley genome with 4.0Gb in size. We employed the falcon assembly package ,scaffolding and error correction tools to finish improvement using PacBio long reads sequencing technology, with contig and scaffold N50 lengths of 1.563Mb and 4.006Mb, respectively, representing more continuous than the original Tibetan hulless barley genome nearly two orders of magnitude. We also re-annotated the new assembly, and reported 61,303 stringent confident putative protein-coding genes, of which 40,457 is HC genes.
DOI: 10.7284/124017
title: Fluorometer data collected during research cruise FK161010 using a WET Labs ECO-FLNTU instrument system onboard the platform RV Falkor

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/124012
title: GNSS (Global Navigation Satellite System) data collected during research cruise FK161010 using a C&C C-Nav 3050 instrument system onboard the platform RV Falkor

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7582181.v1
title: Improved high-quality genome assembly and annotation of Tibetan hulless barley

description: We reported an improved high-quality assembly of Tibetan hulless barley genome with 4.0Gb in size. We employed the falcon assembly package ,scaffolding and error correction tools to finish improvement using PacBio long reads sequencing technology, with contig and scaffold N50 lengths of 1.563Mb and 4.006Mb, respectively, representing more continuous than the original Tibetan hulless barley genome nearly two orders of magnitude. We also re-annotated the new assembly, and reported 61,303 stringent confident putative protein-coding genes, of which 40,457 is HC genes.
DOI: 10.7284/124011
title: Gyrocompass data collected during research cruise FK161010 using a Raytheon STD 22 instrument system onboard the platform RV Falkor

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7582181.v2
title: Improved high-quality genome assembly and annotation of Tibetan hulless barley

description: We reported an improved high-quality assembly of Tibetan hulless barley genome with 4.0Gb in size. We employed the falcon assembly package ,scaffolding and error correction tools to finish improvement using PacBio long reads sequencing technology, with contig and scaffold N50 lengths of 1.563Mb and 4.006Mb, respectively, representing more continuous than the original Tibetan hulless barley genome nearly two orders of magnitude. We also re-annotated the new assembly, and reported 61,303 stringent confident putative protein-coding genes, of which 40,457 is HC genes.
DOI: 10.6084/m9.figshare.7582181.v3
title: Improved high-quality genome assembly and annotation of Tibetan hulless barley

description: We reported an improved high-quality assembly of Tibetan hulless barley genome with 4.0Gb in size. We employed the falcon assembly package ,scaffolding and error correction tools to finish improvement using PacBio long reads sequencing technology, with contig and scaffold N50 lengths of 1.563Mb and 4.006Mb, respectively, representing more continuous than the original Tibetan hulless barley genome nearly two orders of magnitude. We also re-annotated the new assembly, and reported 61,303 stringent confident putative protein-coding genes, of which 40,457 is HC genes.
DOI: 10.7284/124020
title: INS (Inertial Navigation System) data collected during research cruise FK161010 using a Kongsberg Seapath 320 instrument system onboard the platform RV Falkor

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7582181.v4
title: An improved high-quality genome assembly and annotation of Tibetan hulless barley

description: We reported an improved high-quality assembly of Tibetan hulless barley genome with 4.0Gb in size. We employed the falcon assembly package ,scaffolding and error correction tools to finish improvement using PacBio long reads sequencing technology, with contig and scaffold N50 lengths of 1.563Mb and 4.006Mb, respectively, representing more continuous than the original Tibetan hulless barley genome nearly two orders of magnitude. We also re-annotated the new assembly, and reported 61,303 stringent confident putative protein-coding genes, of which 40,457 is HC genes.
DOI: 10.7284/124018
title: Multibeam Echosounder data collected during research cruise FK161010 using a Kongsberg EM302 instrument system onboard the platform RV Falkor

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/124014
title: Singlebeam Echosounder data collected during research cruise FK161010 using a Kongsberg EA600 instrument system onboard the platform RV Falkor

description: Original (unprocessed) data collected during a Field_expedition