cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.25398643.v1
title: Supplementary Material for: Safety and Tolerability of the APOL1 Inhibitor, Inaxaplin, Following Single- and Multiple-ascending Doses in Healthy Adults

description: Introduction
Toxic gain-of-function Apolipoprotein L1 (APOL1) variants contribute to the development of proteinuric nephropathies collectively referred to as APOL1-mediated kidney disease (AMKD). Despite standard-of-care treatments, patients with AMKD experience accelerated progression to end stage kidney disease. The identification of two APOL1 variants as the genetic cause of AMKD inspired development of inaxaplin, an inhibitor of APOL1 channel activity that reduces proteinuria in patients with AMKD.

Methods
We conducted two phase 1 studies evaluating the safety, tolerability, and pharmacokinetics of single-ascending doses (SAD) and multiple-ascending doses (MAD) of inaxaplin in healthy participants. In the SAD cohorts, participants were randomized to receive inaxaplin as a single dose (range, 7.5 mg to 165 mg) or placebo. In the MAD cohorts, participants were randomized to receive multiple doses of inaxaplin (range, 15 to 120 mg daily) or placebo for 14 days. We assessed safety and tolerability based on adverse events (AEs), clinical laboratory values, electrocardiograms (ECGs), and vital signs.

Results
A total of 178 participants were randomized in the SAD/MAD cohorts of both studies (mean age: 36.7 years; 94.9% male). The proportion of participants with any AEs was similar in the inaxaplin (24.6%) and placebo (22.7%) groups. All AEs were mild or moderate in severity; there were no serious AEs. Headache was the most common AE: 10.4% and 2.3% in the inaxaplin and placebo groups, respectively. There were no drug-related treatment discontinuations and no clinically relevant trends in laboratory values, ECGs, or vital signs.

Discussion/Conclusion
Inaxaplin is safe and well tolerated at single doses up to 165 mg and multiple doses up to 120 mg daily for 14 days. These results are consistent with the favorable safety profile of inaxaplin in a completed phase 2a proof-of-concept study. Together, these findings support continued evaluation of inaxaplin in an ongoing phase 2/3 pivotal trial as a potential precision medicine for patients with AMKD.
DOI: 10.15468/dl.rc8wzc
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Gypsophila struthium Loefl.",
 "HasCoordinate is true",
 "Country is Iceland",
 "HasGeospatialIssue is false",
 "Year is greater than or equal to 2000",
 "CoordinateUncertaintyInMeters is less than 10000"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0127619-240321170329656/datasets/export for details.
DOI: 10.15468/dl.errpx7
title: Occurrence Download

description: A dataset containing 52845 species occurrences available in GBIF matching the query:
{
 "and" : [
 "OccurrenceStatus is Present",
 "TaxonKey is Chromolaena odorata (L.) R.M.King & H.Rob."
 ]
}

 The dataset includes 52845 records from 521 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0127553-240321170329656/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.qqryht
title: Occurrence Download

description: A dataset containing 608 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Apteryx owenii Gould, 1847"
 ]
}

 The dataset includes 608 records from 51 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0008475-170714134226665/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.vj6we3
title: Occurrence Download

description: A dataset containing 10485 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Continent is North America",
 "CoordinateUncertaintyInMeters 0.0-10000.0",
 "TaxonKey is Hyla cinerea (Schneider, 1799)",
 "Year 2010-2021"
 ]
}

 The dataset includes 10485 records from 13 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0004781-240130105604617/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.9xted2
title: Occurrence Download

description: A dataset containing 7 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Eugenia lucens Alain"
 ]
}

 The dataset includes 7 records from 5 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0160880-240321170329656/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.qad8d8
title: Occurrence Download

description: A dataset containing 12 species occurrences available in GBIF matching the query:
{
 "and" : [
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "TaxonKey is Marcetia semiriana A.B.Martins"
 ]
}

 The dataset includes 12 records from 7 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0002094-210914110416597/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.u24chg
title: Occurrence Download

description: A dataset containing 1068 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Setonix brachyurus (Quoy & Gaimard, 1830)"
 ]
}

 The dataset includes 1068 records from 41 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0008475-170826194755519/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.u7hzs2
title: Occurrence Download

description: A dataset containing 1016269 species occurrences available in GBIF matching the query:
{
 "and" : [
 "DatasetKey is Edinburgh (E) Herbarium Specimens"
 ]
}

 The dataset includes 1016269 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0034216-210914110416597/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.9n9ung
title: Occurrence Download

description: A dataset containing 31360 species occurrences available in GBIF matching the query:
{
 "DatasetKey" : [
 "is Neuropteren Deutschlands (Neuropterida of Germany)"
 ]
}

 The dataset includes 31360 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0056870-231120084113126/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.elhj9p
title: Occurrence Download

description: A dataset containing 709 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is Australia",
 "TaxonKey is Corymbia confertiflora (F.Muell.) K.D.Hill & L.A.S.Johnson"
 ]
}

 The dataset includes 709 records from 7 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0008475-171219132708484/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.nvnarb
title: Occurrence Download

description: A dataset containing 1 species occurrences available in GBIF matching the query:
{
 "and" : [
 "BasisOfRecord is Human Observation",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "TaxonKey is Dorcatragus Noack, 1894"
 ]
}

 The dataset includes 1 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0282156-200613084148143/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.z9xpg2
title: Occurrence Download

description: A dataset containing 8463 species occurrences available in GBIF matching the query:
{
 "DatasetKey" : [
 "is Bird Species Occurrence in Ramsar Site of Kilombero Valley Floodplains of Tanzania."
 ]
}

 The dataset includes 8463 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0058664-231120084113126/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.2buzo3
title: Occurrence Download

description: A dataset containing 7689 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Puma concolor (Linnaeus, 1771)"
 ]
}

 The dataset includes 7689 records from 123 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0008476-150615163101818/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.gymn3e
title: Occurrence Download

description: A dataset containing 11 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Epidendrum retrosepalum Hágsater, Ric.Fernández & E.Santiago"
 ]
}

 The dataset includes 11 records from 3 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0160881-240321170329656/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.eneuxn
title: Occurrence Download

description: A dataset containing 4888 species occurrences available in GBIF matching the query:
{
 "and" : [
 "CoordinateUncertaintyInMeters 0.0-10000.0",
 "TaxonKey is Osteopilus septentrionalis (Duméril & Bibron, 1841)",
 "Year 2010-2021"
 ]
}

 The dataset includes 4888 records from 9 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0004778-240130105604617/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.s2rkfs
title: Occurrence Download

description: A dataset containing 1338 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Salix triandra L.",
 "MediaType is Image",
 "BasisOfRecord is Human Observation"
 ]
}

 The dataset includes 1338 records from 7 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0002083-210914110416597/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.tlsqc0
title: Occurrence Download

description: A dataset containing 9938 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Acer negundo L.",
 "Geometry POLYGON((-38.58 32.62,-38.58 71.72,71.63 71.72,71.63 32.62,-38.58 32.62))",
 "HasGeospatialIssue is false"
 ]
}

 The dataset includes 9938 records from 134 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0008476-151016162008034/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.xahabw
title: Occurrence Download

description: A dataset containing 664416 species occurrences available in GBIF matching the query:
{
 "and" : [
 {
 "or" : [
 "BasisOfRecord is Observation",
 "BasisOfRecord is Machine Observation",
 "BasisOfRecord is Human Observation"
 ]
 },
 "OccurrenceStatus is Present",
 "TaxonKey is Psittacula krameri (Scopoli, 1769)"
 ]
}

 The dataset includes 664416 records from 309 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0309561-200613084148143/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.dc6a49
title: Occurrence Download

description: A dataset containing 23367 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Gymnogyps californianus (Shaw, 1797))",
 "HasCoordinate is one of (true)",
 "OccurrenceStatus is one of (Present)"
 ]
}

 The dataset includes 23367 records from 33 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0004795-240130105604617/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.p5jraf
title: Occurrence Download

description: A dataset containing 8 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Epidendrum dunstervilleorum Foldats"
 ]
}

 The dataset includes 8 records from 5 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0160882-240321170329656/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.i5cpme
title: Occurrence Download

description: A dataset containing 1118 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Ptychobranchus fasciolaris (Rafinesque, 1820)"
 ]
}

 The dataset includes 1118 records from 16 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0008476-160118175350007/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.k35qsk
title: Occurrence Download

description: A dataset containing 51 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Saxifraga hyperborea R.Br.",
 "MediaType is Image",
 "BasisOfRecord is Human Observation"
 ]
}

 The dataset includes 51 records from 4 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0002102-210914110416597/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.upwgam
title: Occurrence Download

description: A dataset containing 5647 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Lactuca sibirica (L.) Benth. ex Maxim.",
 "HasCoordinate is true",
 "HasGeospatialIssue is false"
 ]
}

 The dataset includes 5647 records from 93 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0004783-240130105604617/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.zmvio7
title: Occurrence Download

description: A dataset containing 1067 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Lophelia pertusa (Linnaeus, 1758)"
 ]
}

 The dataset includes 1067 records from 37 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0008476-160311141623029/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.wbye5b
title: Occurrence Download

description: A dataset containing 152 species occurrences available in GBIF matching the query:
{
 "or" : [
 "TaxonKey is Andriapetalum multiflorum Schott ex Endl.",
 "TaxonKey is Panopsis multiflora (Schott) Ducke"
 ]
}

 The dataset includes 152 records from 35 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0301558-200613084148143/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.x22he9
title: Occurrence Download

description: A dataset containing 263 species occurrences available in GBIF matching the query:
{
 "DatasetKey" : [
 "is KYMA boat-based surveys in Thyrrhenian Sea and Ionian Sea"
 ]
}

 The dataset includes 263 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0004790-240130105604617/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.q7mvxr
title: Occurrence Download

description: A dataset containing 1 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Coeligena bonapartei orina Wetmore, 1953"
 ]
}

 The dataset includes 1 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0008476-160623103540712/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.v9x7ce
title: Occurrence Download

description: A dataset containing 4 species occurrences available in GBIF matching the query:
{
 "and" : [
 "BasisOfRecord is Human Observation",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "TaxonKey is Catagonus Ameghino, 1904"
 ]
}

 The dataset includes 4 records from 3 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0282147-200613084148143/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.cxdwnb
title: Occurrence Download

description: A dataset containing 5733 species occurrences available in GBIF matching the query:
{
 "and" : [
 {
 "or" : [
 "PublishingCountry is Colombia",
 {
 "and" : [
 "Country is Colombia",
 {
 "not" : {
 "Issue" : [
 "is Country coordinate mismatch"
 ]
 }
 }
 ]
 }
 ]
 },
 "TaxonKey is one of (Carollia brevicaudum (Schinz, 1821))"
 ]
}

 The dataset includes 5733 records from 205 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0011043-240314170635999/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.xhv8hu
title: Occurrence Download

description: A dataset containing 9 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Euphorbia ruiziana (Klotzsch & Garcke) Boiss."
 ]
}

 The dataset includes 9 records from 8 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0160883-240321170329656/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.8otpkh
title: Occurrence Download

description: A dataset containing 1040 species occurrences available in GBIF matching the query:
{
 "DatasetKey" : [
 "is Anfibios y Reptiles reportados en humedales del departamento de Córdoba"
 ]
}

 The dataset includes 1040 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0008476-170826194755519/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.rh9axv
title: Occurrence Download

description: A dataset containing 7 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Elaphoglossum nematorhizon Maxon"
 ]
}

 The dataset includes 7 records from 5 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0160884-240321170329656/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.dquw7z
title: Occurrence Download

description: A dataset containing 25084 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Ribes nigrum L.",
 "HasCoordinate is true",
 "Year is greater than or equal to 1970",
 "Year is less than or equal to 2000"
 ]
}

 The dataset includes 25084 records from 150 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0301579-200613084148143/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.w3edmt
title: Occurrence Download

description: A dataset containing 46 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Falsilunatia carcellesi (Dell, 1990)",
 "HasGeospatialIssue is false",
 "HasCoordinate is true",
 {
 "not" : {
 "BasisOfRecord" : [
 "is Fossil"
 ]
 }
 },
 {
 "or" : [
 {
 "not" : {
 "EstablishmentMeans" : [
 "is MANAGED"
 ]
 }
 },
 {
 "not" : {
 "EstablishmentMeans" : [
 "is not null"
 ]
 }
 }
 ]
 },
 {
 "or" : [
 "OccurrenceStatus is Present",
 {
 "not" : {
 "OccurrenceStatus" : [
 "is not null"
 ]
 }
 }
 ]
 }
 ]
}

 The dataset includes 46 records from 10 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0051925-240229165702484/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.8c8830
title: Occurrence Download

description: A dataset containing 2638 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Pyganodon grandis (Say, 1829)"
 ]
}

 The dataset includes 2638 records from 18 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0008477-160118175350007/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.kyh1ea
title: Occurrence Download

description: A dataset containing 21 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Milvus migrans (Boddaert, 1783)",
 "Country is Malaysia"
 ]
}

 The dataset includes 21 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0008477-160526112335914/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.mphwze
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Quercus ×schneideri Vierh.",
 "HasCoordinate is true",
 "Year is greater than or equal to 1970",
 "Year is less than or equal to 2000"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0301546-200613084148143/datasets/export for details.
DOI: 10.15468/dl.jsvxar
title: Occurrence Download

description: A dataset containing 24 species occurrences available in GBIF matching the query:
{
 "and" : [
 "HasGeospatialIssue is false",
 "HasCoordinate is true",
 "OccurrenceStatus is Present",
 {
 "not" : {
 "BasisOfRecord" : [
 "is one of (Fossil, Living Specimen)"
 ]
 }
 },
 "TaxonKey is Sempervivum tectorum L.",
 "Country is Germany",
 "Year is 2023,2024"
 ]
}

 The dataset includes 24 records from 4 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0001073-240321170329656/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.bffhkc
title: Occurrence Download

description: A dataset containing 12794 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Senecio madagascariensis Poir."
 ]
}

 The dataset includes 12794 records from 141 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0315359-200613084148143/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.ua7syx
title: Occurrence Download

description: A dataset containing 159 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Erythrostemon caudatus (A.Gray) Gagnon & G.P.Lewis"
 ]
}

 The dataset includes 159 records from 19 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0160885-240321170329656/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.