cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.3535/snk-068-kyq
title: Turbonilla acuta (Donovan, 1804)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/w0v-0d7-hh7
title: Bembicium vittatum R. A. Philippi, 1846

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.15468/dl.y79cww
title: Occurrence Download

description: A dataset containing 16010 species occurrences available in GBIF matching the query:
{
 "and" : [
 "HasCoordinate is true",
 "TaxonKey is Chamaemespilus alpina"
 ]
}

 The dataset includes 16010 records from 206 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0006514-250811113504898/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.3535/8la-yvk-0qr
title: Succinella oblonga (Draparnaud, 1801)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/k0k-8fm-kk8
title: Pseudamussium clavatum (Poli, 1795)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/xnw-r3c-bq8
title: Alvania hispidula (Monterosato, 1884)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/4j0-3yv-ygr
title: Mimachlamys gloriosa (Reeve, 1853)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/rnq-wq4-c58
title: Saxicavella jeffreysi Winckworth, 1930

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/7xd-gqv-cxr
title: Pusillina marginata (Michaud, 1830)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/nb8-884-1sv
title: Rissoa violacea Desmarest, 1814

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/8fs-4r3-h5b
title: Punctum pygmaeum (Draparnaud, 1801)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/fjj-cyc-h9f
title: Cheilea bulla (Reeve, 1858)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/6v2-zk2-sda
title: Scaeochlamys squamata (Gmelin, 1791)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/j3w-2b9-0wt
title: Cecilioides acicula (O. F. Müller, 1774)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/myt-nbm-vaq
title: Gafrarium numulinum (Lamarck, 1818)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/qmf-lvq-k83
title: Alvania dianiensis Oliverio, 1988

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/8q0-21f-p4q
title: Squamopleura miles (Pilsbry, 1893)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/tpq-kcp-l1y
title: Ampullaceana balthica (Linnaeus, 1758)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/mcp-pw5-e1s
title: Physella acuta (Draparnaud, 1805)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/52e-2kl-sft
title: Chlamys hastata (G. B. Sowerby II, 1842)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/yal-yrs-2mt
title: Acroloxus lacustris (Linnaeus, 1758)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/dq3-1tv-t1a
title: Retusa obtusa (Montagu, 1803)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/qlc-y52-pna
title: Gyraulus albus (O. F. Müller, 1774)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/qyj-vlb-5ps
title: Musculus costulatus (Risso, 1826)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/xmz-pdt-3qh
title: Armiger crista (Linnaeus, 1758)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/gtt-gqa-zvb
title: Anisus vortex (Linnaeus, 1758)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/l2s-hy4-w6g
title: Purpuraturris cryptorraphe (G. B. Sowerby I, 1825)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/8wz-klv-11k
title: Lindapecten muscosus (W. Wood, 1828)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/mey-a5f-rx7
title: Diodora imbricata (G. B. Sowerby II, 1862)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.5517/ccdc.csd.cc2m203v
title: CCDC 2414996: Experimental Crystal Structure Determination

description: Related Article: Lin Zhang, Xuan Zhou, Pinli Dai, Wenchang Gou, Mei Wang, Yu Tian, Yingjian Xu, Chun Li|2025|Org.Lett.|27|8018|doi:10.1021/acs.orglett.5c02356
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.3535/9f0-ywl-29w
title: Nassarius moolenbeeki H. H. Kool, 1995

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.5517/ccdc.csd.cc2mkksk
title: CCDC 2429959: Experimental Crystal Structure Determination

description: Related Article: Xiaoze Bao, Mengyuan Wu, Guishun Bai, Xusheng Duan, Jiangwei Pan, Yang Yang, Zeyu Wang, Xuanrong Sun, Jean Rodriguez, Damien Bonne, Hong Wang|2025|Org.Lett.|27|7908|doi:10.1021/acs.orglett.5c02233
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2mkktl
title: CCDC 2429960: Experimental Crystal Structure Determination

description: Related Article: Xiaoze Bao, Mengyuan Wu, Guishun Bai, Xusheng Duan, Jiangwei Pan, Yang Yang, Zeyu Wang, Xuanrong Sun, Jean Rodriguez, Damien Bonne, Hong Wang|2025|Org.Lett.|27|7908|doi:10.1021/acs.orglett.5c02233
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2n5hp1
title: CCDC 2448153: Experimental Crystal Structure Determination

description: Related Article: Rani Gourkhede, Maravanji S. Balakrishna|2025|Org.Lett.|27|7874|doi:10.1021/acs.orglett.5c02186
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.3535/5pf-9wq-l6b
title: Aequipecten opercularis (Linnaeus, 1758)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/qsp-jry-7ss
title: Littorina saxatilis (Olivi, 1792)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.5517/ccdc.csd.cc2nc2mr
title: CCDC 2453514: Experimental Crystal Structure Determination

description: Related Article: Ryuto Toyoshima, Hiroki Horita, Shiori Tsuda, Shunsuke Kobashi, Hiroto Kobayashi, Yoichi Kobayashi, Hiromitsu Maeda|2025|Org.Lett.|27|7933|doi:10.1021/acs.orglett.5c02265
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.15468/dl.tee82b
title: Occurrence Download

description: A dataset containing 119 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is China",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "TaxonKey is Dendrobium moniliforme"
 ]
}

 The dataset includes 119 records from 16 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0006515-250811113504898/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.3535/9zf-wh3-5n3
title: Bithynia tentaculata (Linnaeus, 1758)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/qlh-2ds-lm8
title: Strophomenia indica (Nierstrasz, 1902)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.5517/ccdc.csd.cc2nrtjs
title: CCDC 2465756: Experimental Crystal Structure Determination

description: Related Article: Yerin Jeong, Sunmi Kim, Sunhee Lee, Dohui Ku, Hyunjin Oh, Ikyon Kim|2025|J.Org.Chem.|90|10282|doi:10.1021/acs.joc.5c00905
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.3535/43n-lpn-ey4
title: Pecten jacobaeus (Linnaeus, 1758)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/saf-f08-t65
title: Bithynia tentaculata (Linnaeus, 1758)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/d1n-5fa-r1k
title: Valvata piscinalis (O. F. Müller, 1774)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/zt3-x9w-hzm
title: Perpolita hammonis (Strøm, 1765)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.6084/m9.figshare.29900405
title: Supplemental File Impact of the melanocortin-4 receptor agonist setmelanotide on MASLD and kidney function in Bardet-Biedl syndrome Huhne et al. 2025

description: Supplementary data related to the orignal article "Impact of the melanocortin-4 receptor agonist setmelanotide on MASLD and kidney function in Bardet-Biedl syndrome" by Hühne et al. (2025)
DOI: 10.6084/m9.figshare.29900405.v1
title: Supplemental File Impact of the melanocortin-4 receptor agonist setmelanotide on MASLD and kidney function in Bardet-Biedl syndrome Huhne et al. 2025

description: Supplementary data related to the orignal article "Impact of the melanocortin-4 receptor agonist setmelanotide on MASLD and kidney function in Bardet-Biedl syndrome" by Hühne et al. (2025)
DOI: 10.3535/fh1-wst-eas
title: Spisula subtruncata (da Costa, 1778)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/1mm-66v-2ge
title: Anisus leucostoma (Millet, 1813)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/hvf-k3g-y3v
title: Zonitoides excavatus (Alder, 1830)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/en8-z73-h71
title: Cecilioides acicula (O. F. Müller, 1774)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.15468/dl.bnajty
title: Occurrence Download

description: A dataset containing 142 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Zosterops rendovae)",
 "HasCoordinate is true",
 "OccurrenceStatus is Present",
 "License is one of (CC-BY 4.0, CC0 1.0)"
 ]
}

 The dataset includes 142 records from 7 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0006516-250811113504898/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.3535/ptx-vv6-z78
title: Cochlicopa lubrica (O. F. Müller, 1774)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/qv7-trj-pwf
title: Calliostoma virgo Schepman, 1908

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/13p-zgg-vdy
title: Arctica islandica (Linnaeus, 1767)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/vdc-h8b-jlq
title: Dosinia erythraea Römer, 1860

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/bvf-mwq-baq
title: Physella acuta (Draparnaud, 1805)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/crz-8yb-g7w
title: Ampullaceana balthica (Linnaeus, 1758)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/a0x-v7m-pk3
title: Epitonium clathrus (Linnaeus, 1758)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/36c-fqd-dnj
title: Chlamydella favus (Hedley, 1902)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/qt2-7we-432
title: Cochlicopa lubrica (O. F. Müller, 1774)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/x36-kkl-1cp
title: Gyraulus albus (O. F. Müller, 1774)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/ftq-8kc-y20
title: Trochulus hispidus (Linnaeus, 1758)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/l9w-hzq-md3
title: Parvamussium retiaculum Dijkstra, 1995

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/lal-0yw-gjm
title: Pupina suavis van Benthem Jutting, 1963

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/m9v-dj8-ft5
title: Euvola ziczac (Linnaeus, 1758)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/h5w-ser-j42
title: Carychium minimum O. F. Müller, 1774

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/x0g-kej-88c
title: Ostrea edulis Linnaeus, 1758

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/m8l-sbt-f0y
title: Perpolita hammonis (Strøm, 1765)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/q3a-qkz-8yl
title: Corbicula fluminea (O. F. Müller, 1774)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/rpk-wpf-tbs
title: Epitonium clathrus (Linnaeus, 1758)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/gcm-8ws-srg
title: Cepaea nemoralis (Linnaeus, 1758)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/dzk-e13-xnt
title: Spisula subtruncata (da Costa, 1778)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/ssx-e41-72x
title: Potamopyrgus antipodarum (J. E. Gray, 1843)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/jd1-80s-wzw
title: Cryptopecten phrygium (Dall, 1886)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/xv2-brx-t2a
title: Trochulus hispidus (Linnaeus, 1758)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/fnc-ch8-8vm
title: Planorbarius corneus (Linnaeus, 1758)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/lv4-tqh-36t
title: Mirapecten mirificus (Reeve, 1853)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/84k-xek-8sd
title: Mimachlamys varia varia (Linnaeus, 1758)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/lzm-5g4-9b6
title: Philine aperta (Linnaeus, 1767)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/ee1-hgt-ey8
title: Acanthochitona biformis (Nierstrasz, 1905)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/b8h-j9d-t7b
title: Neritodryas notabilis Riech, 1935

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/nc9-vms-q1j
title: Jullienia munensis Brandt, 1974

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/019-ym9-7ep
title: Cochlicopa lubricella (Porro, 1838)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/kfs-n54-bmm
title: Euspira catena (da Costa, 1778)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/gfj-9t2-k0h
title: Pecten excavatus Anton, 1838

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/22v-2v1-7mj
title: Amusium pleuronectes (Linnaeus, 1758)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/mj8-nd2-0wf
title: Aegopinella nitidula (Draparnaud, 1805)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/6qp-sel-ryp
title: Lymnaea stagnalis (Linnaeus, 1758)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/f5t-shq-wdg
title: Perpolita hammonis (Strøm, 1765)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/qyz-qeg-1ej
title: Spisula subtruncata (da Costa, 1778)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/s3c-fc8-5y7
title: Cepaea nemoralis (Linnaeus, 1758)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/0vd-cek-n8c
title: Plectostoma sinyumense (Maassen, 2001)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/hkb-44m-wax
title: Trochulus hispidus (Linnaeus, 1758)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/yk3-7h5-1w3
title: Backeljaia gigaxii (L. Pfeiffer, 1847)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.5281/zenodo.16757394
title: Vorapaxar enhanced mitochondria-associated ferroptosis primes cancer immunotherapy via targeting FOXO1/HMOX1 axis

description: Immunotherapy has revolutionized cancer treatment, yet challenges persist, such as resistance and lethal thromboembolism, necessitating dual-purpose strategies. Targeting ferroptosis emerges as a promising strategy to enhance immunotherapy efficacy, prompting our investigation of antiplatelet agents that simultaneously promote ferroptosis and mitigate thromboembolic risks. Through systematic screening of 20 Food and Drug Administration (FDA)-approved antiplatelet agents, we identify vorapaxar as a potent pro-ferroptotic drug. Mechanistically, vorapaxar binds forkhead box O1 (FOXO1), inhibits its phosphorylation at Ser256, and facilitates nuclear translocation to upregulate heme oxygenase 1 (HMOX1), promoting mitochondrial iron overload and mitochondria-associated ferroptosis. Vorapaxar enhances immunotherapy-induced tumor ferroptosis and antitumor immunity across diverse melanoma models, including B16F10 tumor-bearing mice, Braf/Pten-driven spontaneous melanoma mice, and PBMC-humanized mice. Clinically, high FOXO1/HMOX1 co-expression correlates with improved immunotherapy response and progression-free survival. These findings position vorapaxar as a promising adjunct to immunotherapy, offering a dual benefit for cancer patients requiring both antithrombotic therapy and immunotherapy.
DOI: 10.5281/zenodo.16757395
title: Vorapaxar enhanced mitochondria-associated ferroptosis primes cancer immunotherapy via targeting FOXO1/HMOX1 axis

description: Immunotherapy has revolutionized cancer treatment, yet challenges persist, such as resistance and lethal thromboembolism, necessitating dual-purpose strategies. Targeting ferroptosis emerges as a promising strategy to enhance immunotherapy efficacy, prompting our investigation of antiplatelet agents that simultaneously promote ferroptosis and mitigate thromboembolic risks. Through systematic screening of 20 Food and Drug Administration (FDA)-approved antiplatelet agents, we identify vorapaxar as a potent pro-ferroptotic drug. Mechanistically, vorapaxar binds forkhead box O1 (FOXO1), inhibits its phosphorylation at Ser256, and facilitates nuclear translocation to upregulate heme oxygenase 1 (HMOX1), promoting mitochondrial iron overload and mitochondria-associated ferroptosis. Vorapaxar enhances immunotherapy-induced tumor ferroptosis and antitumor immunity across diverse melanoma models, including B16F10 tumor-bearing mice, Braf/Pten-driven spontaneous melanoma mice, and PBMC-humanized mice. Clinically, high FOXO1/HMOX1 co-expression correlates with improved immunotherapy response and progression-free survival. These findings position vorapaxar as a promising adjunct to immunotherapy, offering a dual benefit for cancer patients requiring both antithrombotic therapy and immunotherapy.
DOI: 10.3535/bb3-a47-60w
title: Talochlamys zelandiae (J. E. Gray, 1843)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/hda-gwf-x37
title: Nucella lapillus (Linnaeus, 1758)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/l6y-r97-bgn
title: †Turritella incrassata J. Sowerby, 1814

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/ps6-39y-wxh
title: Bittium reticulatum (da Costa, 1778)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/1dz-cne-6e7
title: Ocenebra erinaceus (Linnaeus, 1758)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/1ck-ktt-v2r
title: Myxas glutinosa (O. F. Müller, 1774)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.