cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.23652384
title: Supplementary Material for: Peritoneal and Urinary Sodium Removal in Refractory Congestive Heart Failure Patients Included in an Ambulatory Peritoneal Dialysis Program: Valuable for Monitoring the Course of the Disease?

description: Introduction: Spot urinary sodium emerged as a useful parameter for assessing decongestion in patients with congestive heart failure (CHF). Growing evidence endorses the therapeutic role of continuous ambulatory peritoneal dialysis (CAPD) in patients with refractory CHF and kidney disease. We aimed to examine the long-term trajectory of urinary, peritoneal, and total (urinary plus peritoneal) sodium removal in a cohort of patients with refractory CHF enrolled in a CAPD program. Additionally, we explored whether sodium removal was associated with the risk of long-term mortality and episodes of worsening heart failure (WHF). Methods: We included 66 ambulatory patients with refractory CHF enrolled in a CAPD program in a single teaching center. 24-hour peritoneal, urinary, and total sodium elimination were analyzed at baseline and after CAPD initiation. Its trajectories over time were calculated using joint modeling of longitudinal and survival data. Within the framework of joint frailty models for recurrent and terminal events, we estimated its prognostic effect on recurrent episodes of WHF. Results: At the time of enrollment, the mean age and estimated glomerular filtration rate (eGFR) were 72.8±8.4 years and 28.5±14.3 mL/min/1.73m2, respectively. The median urinary sodium at baseline was 2.34 g/day (1.40-3.55). At a median (p25%-p75%) follow-up of 2.93 (1.93-3.72) years, we registered 0.28 deaths and 0.24 episodes of WHF per 1 person-years. Compared to baseline (urinary), CAPD led to increased sodium excretion (urinary plus dialyzed) since the first follow-up visit (p&lt;0.001). Over the follow-up, repeated measurements of total sodium removal were associated with a lower risk of death and episodes of WHF. Conclusions: CAPD increased sodium removal in patients with refractory CHF. Elevated sodium removal identified those patients with a lower risk of death and episodes of WHF.
DOI: 10.6084/m9.figshare.23936010
title: Supplementary Material for: Exploration of extracellular vesicle long non-coding RNAs in serum of patients with cervical cancer

description: Cervical cancer (CC) is the fourth most common cancer type and a leading cause of cancer-related deaths in women worldwide. Its underlying molecular mechanisms are unclear. Cancer cell-derived extracellular vesicles (EVs) are involved in cancer development and progression by delivering regulatory factors, including microRNAs and long non-coding RNAs (lncRNAs). Here, we identified the EV lncRNA expression profiles associated with different developmental stages of CC using next-generation sequencing. EVs from the serum of patients with stages I–III CC and healthy donors were characterized using EV marker immunoblotting and transmission electron microscopy. The EV concentration increases with progression of the disease. Most particles had a 100–250 nm diameter, and their sizes were similar in all groups. We identified many lncRNAs that were uniquely and differentially expressed (DE) in patients with different stages of CC. The pathway analysis results indicated that the upregulated DE EV lncRNAs abundant in stages I and II were associated with cell proliferation and inflammatory and cancer progression pathways, respectively. LINC00941, LINC01910, LINC02454, and DSG2-AS1 were highly expressed, suggesting poor overall survival of CC patients. Interestingly, DSG2-AS1 was associated with human papillomavirus infection pathway through AKT3, DLG1, and COL6A2 genes. This is the first study that reports the levels of EVs and their lncRNA contents change during cancer development, demonstrating the existence of a unique vesicle-mediated cell-to-cell communication network underlying cancer progression.
DOI: 10.6084/m9.figshare.24031794
title: Supplementary Material for: Invasive ductal carcinoma of the breast in a transgender man: a case report

description: There is limited literature about breast cancer in the transgender population. Very little is known about how gender-affirming hormone therapy affects their breast cancer risk. On the other end, for those diagnosed with breast cancer, there are no clinical guidelines to manage their breast cancer, specifically, how to manage their gender-affirming hormone therapy during breast cancer treatment. Here we report a 52-year-old transman diagnosed with a grade 2 invasive ductal carcinoma (ER+/PR+/HER2-), and ductal carcinoma in situ (DCIS) of intermediate grade. We discussed his risk factors as well as treatment options.
DOI: 10.6084/m9.figshare.24070947
title: Supplementary Material for: Spinal Dysraphism Presenting as Neuropathic Ulcers: A Case Report of a Delayed Diagnosis

description: Spinal dysraphism (SD) refers to the abnormal fusion of dorsal midline structures during embryogenesis. It encompasses a variety of congenital spinal defects, ranging from an overt defect in which neural tissue is exposed with no overlying skin (open SD) such as myelomeningoceles to skin-covered malformations (closed or "occult" SD). A 13-year-old boy presented with recurrent multiple painless ulcers and erosions over the tips of the toes, mainly involving the right foot with hemorrhagic crusts for five years. A review of systems revealed: back pain, urine incontinence, and numbness in his right knee. He was diagnosed with peripheral neuropathic ulcers and tethered cord syndrome secondary to spinal dysraphism and confirmed by MRI. He underwent cord detethering and lipoma resection as well as expectant therapy with satisfying outcomes. Physicians should consider early diagnosis of SD to avoid later neurological complication of SD (traction and/or pressure on the spinal cord), when infants are presented with such anomalies: MRI, close follow-up, and neurosurgical intervention may be recommended.
DOI: 10.6084/m9.figshare.24105480
title: Supplementary Material for: Rare Case of Bilateral Orbital Cellulitis in An Adult, Caused by Enterococcus Faecalis

description: Orbital cellulitis is a serious life-threatening infection, typically in pediatric patients, and its bilateral presentation in adults is atypic. We present an unusual bilateral manifestation of orbital cellulitis and abscess, caused by Enterococci in an adult patient. E. faecalis is an extremely rare cause of orbital inflammation and we found three published case reports only, all of which are unilateral and seen in children. A 51-year-old male presented with one week history of pyrexia, painful proptosis, periorbital swelling and low vision of both eyes. He was diagnosed with bilateral orbital cellulitis and was treated with empiric antibiotic medication for 8 days, but symptoms persisted. MRI showed bilateral intra- and extraconal fluid-intensity collections. Microbiology was taken from the orbit and revealed Enterococcus faecalis invasion. Pus collections were drained for 1 week. Systemic and intraorbital antibiotics were administered. The patient recovered and vision returned to normal. This is a rare case of bilateral orbital cellulitis and abscesses with invasive E. faecalis infection. E. faecalis infection of the orbit is unusual and should be considered especially if patient does not respond to empiric antibiotic therapies.
DOI: 10.6084/m9.figshare.22323553
title: Supplementary Material for: Glomangiomyoma of the Stomach

description: Glomus tumor (glomus cell tumor) is a rare, often benign neoplasm, which is in most cases seen as a solitary bluish nodule involving the nail beds. Solid glomus tumor, glomangioma, and glomangiomyoma are the three main histopathological variants. In this case report, we present the rarest subtype of a glomus tumor; glomangiomyoma, in an atypical location; the stomach. A 45-year-old female from Syria presented to the clinic with severe dizziness and left epigastric abdominal pain accompanied by melena. We performed a thorough clinical study, laboratory workup, upper gastrointestinal endoscopy, endoscopic ultrasound, CT scan, as well as macroscopic and microscopic histologic examination of the surgical specimen, in addition to the immunohistochemical staining. Although rare, gastric glomangiomyoma was diagnosed and a 4.5 × 3 × 3 cm soft tissue mass was resected from the gastric antrum, and no clinical or endoscopic evidence of recurrence was observed for the follow up duration of four years. Undiagnosed gastric lesion with unexplained symptoms should be further investigated and not be disregarded immediately. To the best of our knowledge, this is only the second report of an instance of gastric glomangiomyoma.
DOI: 10.6084/m9.figshare.22656355
title: Supplementary Material for: Drug induced liver injury caused by Capecitabine: A case report and a literature review

description: Chemotherapy is widely used in cancer treatment, and the drug capecitabine is often used in treatment of breast cancer and usually well tolerated. Toxicity from capecitabine typically involves hand-foot-syndrome, fatigue, nausea, reduced appetite, and diarrhea while severe liver toxicity is rarely seen. We present a case of a 63-year-old female with metastatic breast cancer, without liver metastasis, who developed a severe drug induced liver injury (DILI) with critically elevated liver enzyme levels as reaction to capecitabine treatment with seemingly no evident explanation as to why. The patient had a RUCAM score of 7 and a Naranjo score of 6 implying that this association between Capecitabine and the liver injury falls into the “probable” category. The patient recovered completely and was then successfully treated with other cytotoxic drugs without any sign of liver engagement. An in-depth literature search based on Pubmed database was performed to obtain information about Capecitabine, liver injury, and chemotherapy-associated acute hepatic toxicity. The following keywords were used: Capecitabine, chemotherapy, liver toxicity, and hepatic toxicity. Five studies were found showing some similarities to this case documenting hepatic injury after Capecitabine treatment including hepatic steatosis and moderately elevated liver enzymes. However, no studies were found reporting a severe drug induced liver injury with highly elevated enzyme levels as immediate response to Capecitabine treatment. No reason could be identified as for why the patient developed an acute toxic liver reaction to Capecitabine. This case calls for more attention to the potential severe liver toxicity of an otherwise well-tolerated drug.
DOI: 10.6084/m9.figshare.23735772
title: Supplementary Material for: Children’s use of evaluative devices in response to the Global TALES protocol

description: Introduction: It has been well established that the function of sharing personal narratives is to inform the listener about what the event meant to the narrator, for example by using a range of evaluative devices. The use of these evaluative devices may reflect a person’s understanding of the differences between one’s own mind and others, by expressing their beliefs, emotions, thoughts, and desires. This paper investigates children’s use of evaluative devices when producing personal narratives in response to the six emotion-based prompts contained in the Global TALES protocol (excited, worried, annoyed, proud, problem situation, something important). It addresses three research questions: 1) What types and proportions of evaluative devices do 10-year-old English-speaking children use in response to the six prompts contained in the Global TALES protocol and are there differences in performance between boys and girls? 2) What are the correlations between the different types of evaluative devices? 3) Does children’s use of evaluative devices differ depending on the type of prompt used? Methods: Eighty-two native English-speaking ten-year-old children from three English-speaking countries (Australia, New Zealand, and the US) participated. None of the children had been identified with language- and/or learning difficulties. Children’s personal narratives were transcribed and analyzed for the use of 12 evaluative devices: compulsion, internal emotional states, evaluative words, intensifiers, mental states, causal explanations, hypotheses, objective judgements, subjective judgements, intent, negatives, and repetition. Results: Results showed that children use a high number of evaluative devices, with ‘intensifiers’ and ‘evaluative words’ used most frequently. There were few effects for sex, apart from girls using a wider range of evaluative devices than boys. We found moderate to large correlations between most devices, with factor analysis revealing three factors, we labeled as ‘causality’, ‘hypothesis’, and ‘judgement’. Although there were significant overall effects for prompt type on the use of evaluative devices, there was no clear pattern when inspecting responses to individual prompts. Conclusion: The results from this study shed light on children’s use of evaluative devices to convey the meaning of their personal narratives in response to six different prompts tapping into different emotions. Moving beyond appraising children’s structural language skills when narrating their personal experiences may enhance understanding of interpersonal and intrapersonal aspects of theory of mind, which may inform clinical practices, such as individualized goal setting and intervention choices.
DOI: 10.6084/m9.figshare.23834703
title: Supplementary Material for: THE MANAGEMENT OF ACARDIAC TWINNING - TRAP SEQUENCE: AN INTERNATIONAL SURVEY

description: Introduction: The optimal approach and therapy method for the acardiac twin with a reverse arterial perfusion sequence has not yet been established. The aim of this study is to determine the clinical practice patterns amongst international fetal therapy units in their management of these cases. Methods: A survey was sent to fetal centers across the world via email between December 2020 and December 2021. Results: Responses were obtained from 77% contacted centers. The most frequent ultrasound variables used in the evaluation of TRAP sequence include echocardiographic assessment of the pump twin and umbilical artery Doppler waveforms in the acardiac and pump twins, in 90% and 80% of the centers respectively. Most centers in Europe and Latin America propose an in-utero intervention in all cases. Most centers in Europe and Latin America prefer interstitial laser ablation, whereas radiofrequency ablation is preferred in North America. The earliest gestational age for an intervention is on mean 13 weeks in Europe, which is earlier than the other geographic areas (p = 0.001). Conclusions: Most centers agreed that antenatal evaluation should include echocardiography along with the UA Doppler waveform measurements, and the most frequently used interventions were interstitial laser ablation or RFA at a median between 14 to 26 weeks.
DOI: 10.6084/m9.figshare.23975580
title: Supplementary Material for: MiR-320a acts as a tumor suppressor in somatotroph PitNETs by targeting BCAT1

description: Introduction: Aberrant miR-320a has been reported to be involved in the tumorigenesis of several cancers. In our previous study, we identified the low expression of circulating miR-320a in patients with somatotroph PitNET; however, the role of miR-320a in somatotroph PitNET proliferation is still unclear. Methods: Cell viability and colony formation assays were used to detect the effect of miR-320a and BCAT1 on GH3 cells. TargetScan was used to identify the target genes of miR-320a. Dual luciferase reporter gene assay was used to explore the relation between miR-320a and BCAT1. Transcriptome and proteome analyses were performed between somatotroph PitNETs and healthy controls. The expression level of miR-320a in somatotroph PitNETs were detected by RT‒qPCR and western blot. Results: miR-320a mimics inhibit cell proliferation, while miR-320a inhibitors promote cell proliferation in GH3 cells. An overlap analysis using a Venn diagram revealed that BCAT1 is the only target gene of miR-320a overexpressed in somatotroph PitNETs compared to healthy controls, as revealed by both microarray and proteomics results. A dual luciferase reporter gene assay showed that miR-320a may bind to the BCAT1-3'UTR. The transfection of miR-320a mimics downregulated the expression and miR-320a inhibitors and upregulated the expression of BCAT1 in GH3 cells. The interference of BCAT1 expression in GH3 cells downregulated cell proliferation and growth. Pan-cancer analyses demonstrated that high BCAT1 expression often indicates a poor prognosis. Conclusion: Our findings illustrate that miR-320a may function as a tumor suppressor and BCAT1 may promote tumor progression. miR-320a may inhibit the growth of somatotroph PitNETs by targeting BCAT1.
DOI: 10.6084/m9.figshare.24173538
title: Supplementary Material for: Evaluation of the Neonatal Sequential Organ Failure Assessment and Mortality Risk in Neonates With Early-Onset Infection

description: Background: The discriminative utility of the neonatal sequential organ failure assessment (nSOFA) for early-onset sepsis (EOS) mortality in the neonatal intensive care unit (NICU) is unknown. Objectives: Determine the utility of nSOFA for EOS mortality. Methods: Multicenter, retrospective cohort study of NICU patients with EOS between 2012-2023. nSOFA scores of survivors and non-survivors were compared and area under receiver operating characteristics curve (AUROC) for mortality was calculated. Results: 104 subjects were identified (88 lived, 16 died). AUROC at blood culture collection (T0), 6 hours after collection(T6), and the maximum nSOFA at T0 or T6 (T0-6max) were 0.76 (95% CI 0.62, 0.91), 0.89 (0.80, 0.99), and 0.87 (0.77, 0.97), respectively. Analyses restricted to birthweight (&lt;1.5, &lt;1kg) or gestational age (&lt;32, &lt;29 week) cutoffs revealed AUROC ranges of 0.86-0.92 for T6 and 0.82-0.84 for T0-6max. Conclusions: The nSOFA showed good-to-excellent discrimination of mortality among infants with EOS in the NICU.
DOI: 10.6084/m9.figshare.24249412
title: Supplementary Material for: Successful rechallenge with osimertinib following osimertinib-induced ventricular tachycardia: A case report

description: Osimertinib, a third-generation tyrosine kinase inhibitor, is the first-line treatment for metastatic non-small cell lung cancer (NSCLC) with sensitizing epidermal growth factor receptor mutations. It is known to cause drug-induced cardiotoxicity, including QT prolongation syndrome, heart failure, and ventricular arrhythmias, which can lead to sudden death. Once severe arrhythmias occur, it is difficult to continue osimertinib treatment. We report a case of a 66-year-old woman with recurrent NSCLC after concurrent chemoradiotherapy who experienced osimertinib-induced ventricular arrhythmia causing syncope. The patient was initially treated with concurrent chemoradiotherapy, and genetic testing revealed epidermal growth factor receptor (EGFR) exon 19 deletion. Three years following treatment initiation, the primary tumor progressed, and new bone metastases developed. The patient was diagnosed with recurrent NSCLC and was treated with targeted therapy with osimertinib. On the 10th day of osimertinib administration, syncope occurred. An electrocardiogram showed polymorphic non-sustained ventricular tachycardia, thought to be the cause of syncope. The patient was switched to erlotinib. Two and a half years later, disease progression of the primary lesion was observed. Liquid biopsy showed EGFR T790M resistance mutation. Therefore, osimertinib (40 mg) every other day was started. After confirming the absence of palpitations and of arrhythmias on ECG, osimertinib dosing was increased to 40 mg daily. Thereafter, no further events occurred, and tumor shrinkage was observed. Low-dose osimertinib rechallenge after induced ventricular arrhythmia may be considered as an option under close monitoring; however, osimertinib rechallenge must be carefully selected based on the risk-benefit analysis.
DOI: 10.6084/m9.figshare.23635239
title: Supplementary Material for: Haploidentical stem cell transplantation using post-transplant cyclophosphamide for T-cell prolymphocytic leukemia after alemtuzumab induction therapy: a case report

description: T-cell prolymphocytic leukemia (T-PLL) is a rare aggressive disease with a poor prognosis. Allogeneic stem cell transplantation (allo-SCT) followed by administration of alemtuzumab is the most promising treatment for T-PLL but is associated with a higher risk of infections since alemtuzumab strongly suppresses cellular immunity, leading to high transplant-related mortality and unsatisfactory survival. In addition, for patients without human leukocyte antigen-matched donors, haploidentical stem cell transplantation (haplo-SCT) using post-transplant cyclophosphamide (PTCy) has been used because of the ready availability of donors and results comparable to transplantation with human leukocyte-antigen matched donors. However, there are only a few reports on such transplantation for T-PLL, and the safety and efficacy of haplo-SCT after alemtuzumab therapy has remained unclear. Here, we describe a 66-year-old Japanese male patient with T-PLL treated successfully with haplo-SCT after induction therapy of alemtuzumab for T-PLL. About three months after the achievement of complete remission by alemtuzumab for T-PLL, haplo-SCT with reduced-intensity conditioning and PTCy was performed. Infectious complications were improved by early therapeutic interventions, and peripheral T cell counts gradually recovered. The patient has remained alive for more than 16 months after allo-SCT with no signs of relapse. Thus, haplo-SCT using PTCy should be considered as an option after alemtuzumab treatment for T-PLL.
DOI: 10.5281/zenodo.5745446
title: Dataset for Eye image effect in the context of pedestrian safety: a French questionnaire study

description: Dataset for the paper Eye image effect in the context of pedestrian safety: a French questionnaire study Introduction: Human behavior is therefore influenced by the presence of others, which scientists also call ‘the audience effect’. The use of social control to produce more cooperative behaviors may positively influence road use and safety. This study uses an online questionnaire to test how eyes images affect the behavior of pedestrians when crossing a road. Material and methods: Different eyes images of men, women and a child with different facial expressions -neutral, friendly and angry- were presented to participants who were asked what they would feel by looking at these images before crossing a signalized road. Participants completed a questionnaire of 20 questions about pedestrian behaviors (PBQ). The questionnaire was received by 1,447 French participants, 610 of whom answered the entire questionnaire. 71% of participants were women, and the mean age was 35±14 years. Results: Eye images give individuals the feeling they are being observed at 33%, feared at 5% and surprised at 26%, and thus seem to indicate mixed results about avoiding crossing at the red light. The expressions shown in the eyes are also an important factor: feelings of being observed increased by about 10-15% whilst feelings of being scared or inhibited increased by about 5% as the expression changed from neutral to friendly to angry. No link was found between the results of our questionnaire and those of the Pedestrian Behavior Questionnaire (PBQ). Conclusion: This study shows that the use of eye images could reduce illegal crossings by pedestrians, and is thus of key interest as a practical road safety tool. However, the effect is limited and how to increase this nudge effect needs further consideration.
DOI: 10.5281/zenodo.8392909
title: Supporting data for: What controls ozone sensitivity in the upper tropical troposphere?

description: We provide here the supporting dataset for our study on ozone sensitivity in the upper tropical troposphere.