cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.5129683.v1
title: Supplementary Material for: Pure Lymphoepithelioma-Like Carcinoma Originating from the Urinary Bladder

description: Lymphoepithelioma-like carcinoma of the urinary bladder (LELCB) is a rare variant of infiltrating urothelial carcinoma. We report a case of LELCB in a 43-year-old man. Ultrasonography and cystoscopy revealed two bladder tumors, one on the left side of the trigone and the other on the right side of the trigone. Transurethral resection of the bladder tumors was performed and pathological analysis revealed undifferentiated carcinoma. We therefore performed radical cystectomy and urinary diversion. Immunohistochemically the tumor cells were positive for cytokeratin, but negative for Epstein-Barr virus-encoded small RNA in situ hybridization as found for previous cases of LELCB. The final pathological diagnosis was a lymphoepithelioma-like variant of urothelial carcinoma with perivesical soft tissue invasion. For adjuvant systemic chemotherapy, three courses of cisplatin were administered. The patient subsequently became free of cancer 72 months postoperatively. Based on the literature, pure or predominant LELCB types show favorable prognoses due to their sensitivity to chemotherapy or radiotherapy. An analysis of the apparent diffusion coefficient (ADC) values of bladder tumors examined in our institution revealed that the ADC value measured for this LELCB was relatively low compared to conventional urothelial carcinomas. This suggests that measuring the ADC value of a lymphoepithelioma-like carcinoma prior to operation may be helpful in predicting LELCB.
DOI: 10.6084/m9.figshare.5129662
title: Supplementary Material for: Novel Approach to Cardiovascular Outcome Prediction in Haemodialysis Patients

description: <b><i>Background:</i></b> Cardiovascular mortality is high in haemodialysis (HD) patients. Arterial stiffness and global longitudinal strain (GLS) are important non-atheromatous cardiovascular risk predictors. No study has encompassed both parameters in a combined model for prediction of outcomes in HD patients. This is important because left ventricular (LV) dysfunction can result from fibrotic remodelling secondary to increased arterial stiffness. <b><i>Methods:</i></b> Two hundred and nineteen HD patients had pulse wave velocity (PWV) and echocardiography (including GLS) assessments. Patients were followed-up until death, transplantation or November 16, 2015, whichever happened first. Pearson's correlation coefficient was used to determine factors associated with PWV and GLS. A multivariable Cox regression model investigated factors associated with all-cause, cardiac death and events. <b><i>Results:</i></b> One hundred and ninety eight HD patients had full datasets (median age 64.2, 68.7% males) with a mean LV ejection fraction (LVEF) of 61.7 ± 10.1% and GLS -13.5 ± 3.3%; 51% had LV hypertrophy. Forty eight deaths (15 cardiac) and 44 major cardiac events occurred during a median follow-up of 27.6 (25th-75th percentile, 17.3-32.7) months. In separate survival models, PWV and GLS were independently associated with all-cause mortality; however, in a combined model, LV mass indexed to height<sup>2.7</sup> (LVMI/HT<sup>2.7</sup>; adjusted hazard ratio (HR) 1.02, 95% CI 1.00-1.04) and PWV (adjusted HR 1.23, 95% CI 1.03-1.47) were significant. PWV was neither associated with cardiac death nor associated with related cardiac events. However, GLS was associated with cardiac death (adjusted HR 1.24, 95% CI 1.00-1.54) and cardiac events (adjusted HR 1.13, 95% CI 1.03-1.25). <b><i>Conclusions:</i></b> PWV and LVMI/HT<sup>2.7</sup> were superior to GLS in prediction of all-cause mortality. However, GLS was associated with cardiac death and events even when accounting for LVEF and LVMI/HT<sup>2.7</sup>.
DOI: 10.6084/m9.figshare.5129671
title: Supplementary Material for: Characterization of Kidney and Skeleton Phenotypes of Mice Double Heterozygous for Foxc1 and Foxc2

description: Foxc1 and Foxc2 play key roles in mouse development. Foxc1 mutant mice develop duplex kidneys with double ureters, and lack calvarial and sternal bones. Foxc2 null mice have been reported to have glomerular abnormalities in the kidney and axial skeletal anomalies. Expression patterns of Foxc1 and Foxc2 overlap extensively and are believed to have interactive roles. However, cooperative roles of these factors in glomerular and skeletal development are unknown. Therefore, we examined the kidneys and skeleton of mice that were double heterozygous for Foxc1 and Foxc2. Double heterozygotes were generated by mating single heterozygotes for Foxc1 and Foxc2. Newborn double heterozygous mice showed many anomalies in the kidney and urinary tract resembling Foxc1 phenotypes, including duplex kidneys, double ureters, hydronephrosis and mega-ureter. Some mice had hydronephrosis alone. In addition to these macroscopic anomalies, some mice had abnormal glomeruli and disorganized glomerular capillaries observed in Foxc2 phenotypes. Interestingly, these mice also showed glomerular cysts not observed in the single-gene knockout of either Foxc1 or Foxc2 but observed in conditional knockout of Foxc2 in the kidney. Serial section analysis revealed that all cystic glomeruli were connected to proximal tubules, precluding the possibility of atubular glomeruli resulting in cyst formation. Dorsally opened vertebral arches and malformations of sternal bones in the double heterozygotes were phenotypes similar to Foxc1 null mice. Absent or split vertebral bodies in the double heterozygotes were phenotypes similar to Foxc2 null mice, whilst hydrocephalus noted in the Foxc1 phenotype was not observed. Thus, Foxc1 and Foxc2 have a role in kidney and axial skeleton development. These transcription factors might interact in the regulation of the embryogenesis of these organs.
DOI: 10.6084/m9.figshare.5129665.v1
title: Supplementary Material for: Antimicrobial Susceptibility among European Gram-Negative and Gram-Positive Isolates Collected as Part of the Tigecycline Evaluation and Surveillance Trial (2004-2014)

description: <b><i>Background:</i></b> European centers (n = 226) involved in the Tigecycline Evaluation and Surveillance Trial (TEST, 2004-2014) submitted data and bacterial isolates. <b><i>Methods:</i></b> Minimal inhibitory concentrations and susceptibility were determined using Clinical and Laboratory Standards Institute methods and European Committee on Antimicrobial Susceptibility Testing breakpoints. <b><i>Results:</i></b> The rates of the following resistant pathogens increased from 2004 to 2014: extended-spectrum β-lactamase (ESBL)-positive <i>Escherichia coli</i> (from 8.9 to 16.9%), multidrug-resistant <i>Acinetobacter baumannii</i> complex (from 15.4 to 48.5%), and ESBL-positive <i>Klebsiella pneumoniae</i> (from 17.2 to 23.7%). The rate of methicillin-resistant <i>Staphylococcus aureus</i> was 27.5% in 2004 and 28.9% in 2014. Resistance to the carbapenems (imipenem and meropenem) was 37.4 and 14.5% for <i>A. baumannii</i> complex and <i>Pseudomonas aeruginosa</i>, respectively. Carbapenem resistance was ≤4.3% among the Enterobacteriaceae and 0.2% against <i>Streptococcus pneumoniae.</i> The resistance to tigecycline ranged between 7.4% against ESBL-producing <i>K. pneumoniae </i>and 0.0% against <i>S. aureus.</i><b><i>Conclusions:</i></b> The carbapenems and tigecycline were active against Enterobacteriaceae. Agents with activity against <i>A. baumannii</i> complex and <i>P. aeruginosa</i> are limited. The carbapenems, tigecycline, linezolid, and vancomycin were active against Gram-positive organisms.
DOI: 10.6084/m9.figshare.5129671.v1
title: Supplementary Material for: Characterization of Kidney and Skeleton Phenotypes of Mice Double Heterozygous for Foxc1 and Foxc2

description: Foxc1 and Foxc2 play key roles in mouse development. Foxc1 mutant mice develop duplex kidneys with double ureters, and lack calvarial and sternal bones. Foxc2 null mice have been reported to have glomerular abnormalities in the kidney and axial skeletal anomalies. Expression patterns of Foxc1 and Foxc2 overlap extensively and are believed to have interactive roles. However, cooperative roles of these factors in glomerular and skeletal development are unknown. Therefore, we examined the kidneys and skeleton of mice that were double heterozygous for Foxc1 and Foxc2. Double heterozygotes were generated by mating single heterozygotes for Foxc1 and Foxc2. Newborn double heterozygous mice showed many anomalies in the kidney and urinary tract resembling Foxc1 phenotypes, including duplex kidneys, double ureters, hydronephrosis and mega-ureter. Some mice had hydronephrosis alone. In addition to these macroscopic anomalies, some mice had abnormal glomeruli and disorganized glomerular capillaries observed in Foxc2 phenotypes. Interestingly, these mice also showed glomerular cysts not observed in the single-gene knockout of either Foxc1 or Foxc2 but observed in conditional knockout of Foxc2 in the kidney. Serial section analysis revealed that all cystic glomeruli were connected to proximal tubules, precluding the possibility of atubular glomeruli resulting in cyst formation. Dorsally opened vertebral arches and malformations of sternal bones in the double heterozygotes were phenotypes similar to Foxc1 null mice. Absent or split vertebral bodies in the double heterozygotes were phenotypes similar to Foxc2 null mice, whilst hydrocephalus noted in the Foxc1 phenotype was not observed. Thus, Foxc1 and Foxc2 have a role in kidney and axial skeleton development. These transcription factors might interact in the regulation of the embryogenesis of these organs.
DOI: 10.6084/m9.figshare.5129653
title: Supplementary Material for: Padma 28 bei venösem Ulcus cruris und durch chronisch-venöse Insuffizienz bedingten Ödemen - ein Fallbericht aus der Praxis

description: Medicine
DOI: 10.6084/m9.figshare.5129659
title: Supplementary Material for: Changes in Markers of Mineral and Bone Disorders and Mortality in Incident Hemodialysis Patients

description: <b><i>Background:</i></b> Abnormalities in mineral and bone disorder (MBD) markers are common in patients with chronic kidney disease. However, previous studies have not accounted for their changes over time, and it is unclear whether these changes are associated with survival. <b><i>Methods:</i></b> We examined the association of change in MBD markers (serum phosphorus (Phos), albumin-corrected calcium (Ca<sub>Alb</sub>), intact parathyroid hormone (iPTH) and alkaline phosphatase (ALP)) during the first 6 months of hemodialysis (HD) with all-cause mortality across baseline MBD strata using survival models adjusted for clinical characteristics and laboratory measurements in 102,754 incident HD patients treated in a large dialysis organization between 2007 and 2011. <b><i>Results:</i></b> Across all MBD markers (Phos, Ca<sub>Alb</sub>, iPTH and ALP), among patients whose baseline MBD levels were higher than the reference range, increase in MBD levels was associated with higher mortality (reference group: MBD level within reference range at baseline and no change at 6 months follow-up). Conversely, decrease in Phos and iPTH, among baseline Phos and iPTH levels lower than the reference range, respectively, were associated with higher mortality. An increase in ALP was associated with higher mortality across baseline strata of ALP ≥80 U/l. However, patients with baseline ALP &lt;80 U/l trended towards a lower risk of mortality irrespective of the direction of change at 6 months follow-up. <b><i>Conclusions:</i></b> There is a differential association between changes in MBD markers with mortality across varying baseline levels in HD patients. Further study is needed to determine if consideration of both baseline and longitudinal changes in the management of MBD derangements improves outcomes in this population.
DOI: 10.6084/m9.figshare.5129677.v1
title: Supplementary Material for: High Plasma D-Dimer Indicates Unfavorable Outcome of Acute Ischemic Stroke Patients Receiving Intravenous Thrombolysis

description: <b><i>Background:</i></b> D-dimer is a fibrin degradation product and a possible marker of thromboembolic events. The aim of this study was to investigate the relationship between D-dimer levels and outcome in acute ischemic stroke (AIS) patients receiving intravenous thrombolysis. <b><i>Methods:</i></b> This retrospective study included AIS patients who received intravenous thrombolysis with recombinant tissue plasminogen activator (rt-PA) and provided plasma D-dimer level within 24 h after stroke onset during 2009 and 2014 at a single medical center. Unfavorable outcome was defined as modified Rankin scale ≥3 at 3 months after stroke. Symptomatic intracerebral hemorrhage (ICH) was defined as a deterioration of at least 4 points on the National Institutes of Health Stroke Scale within 36 h post thrombolysis. <b><i>Results:</i></b> Of 347 patients receiving intravenous rt-PA, 159 (mean age 67.6 ± 13.1 year, 59.7% male) fulfilled the inclusion criteria. In univariate analysis, patients with unfavorable outcome (n = 79) had significantly higher levels of D-dimer than those with favorable outcome (median ln D-dimer = 1.4 vs. 0.7 μg/ml, p &lt; 0.001). After adjustment for clinical variables, a higher level of D-dimer remained significantly associated with an unfavorable outcome (OR 1.90, 95% CI 1.27-2.86, p = 0.002) and the occurrence of symptomatic ICH (OR 2.97, 95% CI 1.15-7.70, p = 0.025). <b><i>Conclusion:</i></b> The D-dimer level within 24 h after stroke onset can be an early outcome indicator in AIS patients receiving rt-PA therapy.
DOI: 10.6084/m9.figshare.5129650
title: Supplementary Material for: Reparation of Isoniazid and Rifampicin Combinatorial Therapy-Induced Hepatotoxic Effects by <b><i>Bacopa monnieri</i></b>

description: Drug-induced liver injury is a major challenge in treating tuberculosis with isoniazid (INH) and rifampicin (RIF). This study was aimed at evaluating the protective effects of <i>Bacopa</i><i>monnieri</i> (Brahmi) against INH and RIF-induced hepatotoxicity in a rat model and also to study the patterns of interaction between pregnane X receptor (PXR) and chosen active compounds of <i>B. monnieri</i>. Hepatotoxicity was induced in the experimental animals by the oral administration of INH and RIF (50 mg/kg b.w. each/day) for 28 days. The effects of co-administration of <i>B. monnieri</i> (500 mg/kg b.w./day) in INH- and RIF-induced rats were studied by the estimation of biochemical analyses. The standard hepatoprotective drug silymarin (25 mg/kg b.w./day) was used for the purpose of comparison. In silico docking experiments were carried out using the PatchDock server and the results were analysed on the PyMol molecular viewer. There was significant reduction in the antioxidant status of INH and RIF-induced rats. Also, there was significant elevation in the levels of serum liver function markers in the INH- and RIF-induced rats. <i>B. monnieri</i> was able to normalise the tested parameters. In silico studies reveal significant interaction between PXR and bacopaside I. <i>B. monnieri</i> exerts significant protective effects against INH and RIF-induced hepatotoxicity in rats.
DOI: 10.48370/ofd/52yzk7
title: Sorex araneus - 26446, Zoological collection of the Mammal Research Institute, PAS

description: Sorex araneus (Common shrew) from Zoological collection of the Mammal Research Institute, PAS. Collected 1961-11-01, in: Białowieża National Park, Poland. Material type:
DOI: 10.48370/ofd/2eoprx
title: Sorex araneus - 20116, Zoological collection of the Mammal Research Institute, PAS

description: Sorex araneus (Common shrew) from Zoological collection of the Mammal Research Institute, PAS. Collected 1958-07-22, in: Białowieża National Park, Poland. Material type:
DOI: 10.48370/ofd/gs6asu
title: Sorex araneus - 1939, Zoological collection of the Mammal Research Institute, PAS

description: Sorex araneus (Common shrew) from Zoological collection of the Mammal Research Institute, PAS. Collected 1953-07-01, in: Białowieża National Park, Poland. Material type:
DOI: 10.48370/ofd/augnnj
title: Sorex araneus - 12149, Zoological collection of the Mammal Research Institute, PAS

description: Sorex araneus (Common shrew) from Zoological collection of the Mammal Research Institute, PAS. Collected 1955-08-05, in: Białowieża National Park, Poland. Material type:
DOI: 10.48370/ofd/hwm2e0
title: Sorex araneus - 6333, Zoological collection of the Mammal Research Institute, PAS

description: Sorex araneus (Common shrew) from Zoological collection of the Mammal Research Institute, PAS. Collected 1954-08-26, in: Białowieża National Park, Poland. Material type:
DOI: 10.48370/ofd/vci8d0
title: Sorex araneus - 21064, Zoological collection of the Mammal Research Institute, PAS

description: Sorex araneus (Common shrew) from Zoological collection of the Mammal Research Institute, PAS. Collected 1959-04-23, in: Białowieża National Park, Poland. Material type:
DOI: 10.48370/ofd/b0b9kt
title: Sorex araneus - 20379, Zoological collection of the Mammal Research Institute, PAS

description: Sorex araneus (Common shrew) from Zoological collection of the Mammal Research Institute, PAS. Collected 1958-09-19, in: Białowieża National Park, Poland. Material type:
DOI: 10.48370/ofd/slxa0i
title: Sorex araneus - 5052, Zoological collection of the Mammal Research Institute, PAS

description: Sorex araneus (Common shrew) from Zoological collection of the Mammal Research Institute, PAS. Collected 1954-07-09, in: Białowieża National Park, Poland. Material type:
DOI: 10.48370/ofd/4vquo6
title: Sorex araneus - 11748, Zoological collection of the Mammal Research Institute, PAS

description: Sorex araneus (Common shrew) from Zoological collection of the Mammal Research Institute, PAS. Collected 1955-07-27, in: Białowieża National Park, Poland. Material type:
DOI: 10.48370/ofd/d2n1id
title: Sorex araneus - 18571, Zoological collection of the Mammal Research Institute, PAS

description: Sorex araneus (Common shrew) from Zoological collection of the Mammal Research Institute, PAS. Collected 1957-07-19, in: Białowieża National Park, Poland. Material type:
DOI: 10.48370/ofd/e4cjpy
title: Sorex araneus - 14434, Zoological collection of the Mammal Research Institute, PAS

description: Sorex araneus (Common shrew) from Zoological collection of the Mammal Research Institute, PAS. Collected 1955-09-19, in: Białowieża National Park, Poland. Material type:
DOI: 10.48370/ofd/2wtghd
title: Sorex araneus - 19547, Zoological collection of the Mammal Research Institute, PAS

description: Sorex araneus (Common shrew) from Zoological collection of the Mammal Research Institute, PAS. Collected 1957-12-21, in: Białowieża National Park, Poland. Material type:
DOI: 10.48370/ofd/yztjin
title: Sorex araneus - 162262, Zoological collection of the Mammal Research Institute, PAS

description: Sorex araneus (Common shrew) from Zoological collection of the Mammal Research Institute, PAS. Collected 1992-07-31, in: Białowieża National Park, Poland. Material type:
DOI: 10.48370/ofd/tki6ee
title: Sorex araneus - 76538, Zoological collection of the Mammal Research Institute, PAS

description: Sorex araneus (Common shrew) from Zoological collection of the Mammal Research Institute, PAS. Collected 1968-08-10, in: Białowieża National Park, Poland. Material type:
DOI: 10.48370/ofd/yoqxxq
title: Sorex araneus - 91017, Zoological collection of the Mammal Research Institute, PAS

description: Sorex araneus (Common shrew) from Zoological collection of the Mammal Research Institute, PAS. Collected 1970-06-14, in: Białowieża National Park, Poland. Material type:
DOI: 10.48370/ofd/i060g4
title: Sorex araneus - 104352, Zoological collection of the Mammal Research Institute, PAS

description: Sorex araneus (Common shrew) from Zoological collection of the Mammal Research Institute, PAS. Collected 1972-02-22, in: Białowieża National Park, Poland. Material type:
DOI: 10.48370/ofd/5cczsw
title: Sorex araneus - 13080, Zoological collection of the Mammal Research Institute, PAS

description: Sorex araneus (Common shrew) from Zoological collection of the Mammal Research Institute, PAS. Collected 1955-08-28, in: Białowieża National Park, Poland. Material type:
DOI: 10.48370/ofd/w6vnhe
title: Sorex araneus - 25317, Zoological collection of the Mammal Research Institute, PAS

description: Sorex araneus (Common shrew) from Zoological collection of the Mammal Research Institute, PAS. Collected 1961-07-25, in: Białowieża National Park, Poland. Material type:
DOI: 10.48370/ofd/bkilv2
title: Sorex araneus - 17766, Zoological collection of the Mammal Research Institute, PAS

description: Sorex araneus (Common shrew) from Zoological collection of the Mammal Research Institute, PAS. Collected 1957-01-31, in: Białowieża National Park, Poland. Material type:
DOI: 10.48370/ofd/zdgwug
title: Sorex araneus - 110095, Zoological collection of the Mammal Research Institute, PAS

description: Sorex araneus (Common shrew) from Zoological collection of the Mammal Research Institute, PAS. Collected 1973-05-30, in: Białowieża National Park, Poland. Material type:
DOI: 10.48370/ofd/hzjiqq
title: Sorex araneus - 18820, Zoological collection of the Mammal Research Institute, PAS

description: Sorex araneus (Common shrew) from Zoological collection of the Mammal Research Institute, PAS. Collected 1957-08-22, in: Białowieża National Park, Poland. Material type:
DOI: 10.48370/ofd/23tmja
title: Sorex araneus - 40421, Zoological collection of the Mammal Research Institute, PAS

description: Sorex araneus (Common shrew) from Zoological collection of the Mammal Research Institute, PAS. Collected 1964-10-14, in: Białowieża National Park, Poland. Material type:
DOI: 10.48370/ofd/hvb6xq
title: Sorex araneus - 31062, Zoological collection of the Mammal Research Institute, PAS

description: Sorex araneus (Common shrew) from Zoological collection of the Mammal Research Institute, PAS. Collected 1962-11-30, in: Białowieża National Park, Poland. Material type:
DOI: 10.48370/ofd/0beuot
title: Sorex araneus - 3638, Zoological collection of the Mammal Research Institute, PAS

description: Sorex araneus (Common shrew) from Zoological collection of the Mammal Research Institute, PAS. Collected 1953-09-10, in: Białowieża National Park, Poland. Material type:
DOI: 10.48370/ofd/h1ebrr
title: Sorex araneus - 115406, Zoological collection of the Mammal Research Institute, PAS

description: Sorex araneus (Common shrew) from Zoological collection of the Mammal Research Institute, PAS. Collected 1974-09-29, in: Białowieża National Park, Poland. Material type:
DOI: 10.48370/ofd/xcqf2m
title: Sorex araneus - 24463, Zoological collection of the Mammal Research Institute, PAS

description: Sorex araneus (Common shrew) from Zoological collection of the Mammal Research Institute, PAS. Collected 1961-05-12, in: Białowieża National Park, Poland. Material type:
DOI: 10.48370/ofd/0quxiq
title: Sorex araneus - 52081, Zoological collection of the Mammal Research Institute, PAS

description: Sorex araneus (Common shrew) from Zoological collection of the Mammal Research Institute, PAS. Collected 1966-06-17, in: Białowieża National Park, Poland. Material type:
DOI: 10.48370/ofd/qm0sgh
title: Sorex araneus - 76259, Zoological collection of the Mammal Research Institute, PAS

description: Sorex araneus (Common shrew) from Zoological collection of the Mammal Research Institute, PAS. Collected 1968-07-27, in: Białowieża National Park, Poland. Material type:
DOI: 10.48370/ofd/nlfa4b
title: Sorex araneus - 4974, Zoological collection of the Mammal Research Institute, PAS

description: Sorex araneus (Common shrew) from Zoological collection of the Mammal Research Institute, PAS. Collected 1954-07-05, in: Białowieża National Park, Poland. Material type:
DOI: 10.48370/ofd/antkre
title: Sorex araneus - 34641, Zoological collection of the Mammal Research Institute, PAS

description: Sorex araneus (Common shrew) from Zoological collection of the Mammal Research Institute, PAS. Collected 1964-01-22, in: Białowieża National Park, Poland. Material type: