cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.4496039
title: Light scattering spectroscopy identifies the malignant potential of pancreatic cysts during endoscopy

description: Data from Zhang L., D. K. Pleskow, V. Turzhitsky, E. U. Yee, T.
M. Berzin, M. Sawhney, S. Shinagare, E. Vitkin, Y. Zakharov, U. Khan, F. Wang,
J. D. Goldsmith, S. Goldberg, R. Chuttani, I. Itzkan, L. Qiu, & L. T.
Perelman. 2017. Light scattering spectroscopy identifies the malignant
potential of pancreatic cysts during endoscopy.
DOI: 10.6084/m9.figshare.4496714
title: Inter annual, spatial, seasonal, and diurnal variability of precipitable water vapour over northeast India using GPS time series

description: We present multi-scale variability of GPS-derived column integrated precipitable water vapour (PWV) estimated over five continuous GPS sites of northeast India from 2004 to 2012. PWV is estimated from GPS-derived zenith total delay using observed surface pressure and temperature from collocated meteorological sensors as well as obtained by interpolating European Centre for Medium-Range Weather Forecasts (ECMWF) reanalysis project (ERA-Interim) global reanalysis dataset. PWV estimated using ERA-Interim-derived parameters compare well with the PWV estimated using observed meteorological parameters with bias of less than ± 0.1 mm and highest root mean square error of 0.56 mm. The average PWV for the study period is about 17 mm at Bomdila in the Eastern Himalayas, about 20 mm at Shillong in Shillong plateau, about 31 mm at Lumami in Arokan-Yoma Hill ranges, and about 43 mm at Guwahati and Tezpur in Assam valley. The high altitude sites show low annual PWV variability (around 49%) than the low altitude sites (around 63–67%). Seasonal PWV value coincides with the monsoon with maximum in summer and minimum in the winter. However, percentage seasonal PWV variability is found to be almost same (around 68%) for all the five sites. The Assam valley sites do not show a distinct diurnal cycle whereas the high altitude sites indicate a distinct diurnal cycle coinciding with the daily solar cycle. Insights in to GPS PWV variability and rainfall are presented for the study period.
DOI: 10.6084/m9.figshare.4496714.v1
title: Inter annual, spatial, seasonal, and diurnal variability of precipitable water vapour over northeast India using GPS time series

description: We present multi-scale variability of GPS-derived column integrated precipitable water vapour (PWV) estimated over five continuous GPS sites of northeast India from 2004 to 2012. PWV is estimated from GPS-derived zenith total delay using observed surface pressure and temperature from collocated meteorological sensors as well as obtained by interpolating European Centre for Medium-Range Weather Forecasts (ECMWF) reanalysis project (ERA-Interim) global reanalysis dataset. PWV estimated using ERA-Interim-derived parameters compare well with the PWV estimated using observed meteorological parameters with bias of less than ± 0.1 mm and highest root mean square error of 0.56 mm. The average PWV for the study period is about 17 mm at Bomdila in the Eastern Himalayas, about 20 mm at Shillong in Shillong plateau, about 31 mm at Lumami in Arokan-Yoma Hill ranges, and about 43 mm at Guwahati and Tezpur in Assam valley. The high altitude sites show low annual PWV variability (around 49%) than the low altitude sites (around 63–67%). Seasonal PWV value coincides with the monsoon with maximum in summer and minimum in the winter. However, percentage seasonal PWV variability is found to be almost same (around 68%) for all the five sites. The Assam valley sites do not show a distinct diurnal cycle whereas the high altitude sites indicate a distinct diurnal cycle coinciding with the daily solar cycle. Insights in to GPS PWV variability and rainfall are presented for the study period.
DOI: 10.6084/m9.figshare.4524461
title: Data.rar

description: These data files are related to the research article "Robust Virtual Target Guidance for the Fixed-trim Vehicle under Multi-constraints".
DOI: 10.6084/m9.figshare.4524461.v1
title: Data.rar

description: These data files are related to the research article "Robust Virtual Target Guidance for the Fixed-trim Vehicle under Multi-constraints".
DOI: 10.6084/m9.figshare.4524836
title: SUMOylation of KLF4 promotes IL-4 induced macrophage M2 polarization

description: Macrophages, in response to different environmental cues, undergo the classical polarization (M1 macrophages) as well as the alternative polarization (M2 macrophages) that involve the functions of stimulus-specific transcription factors. Kruppel-like factor 4 (KLF4), a member of a subfamily of the zinc-finger class of DNA-binding transcription factors, plays as a critical regulator of macrophage polarization. KLF4 has been reported as a SUMOylated protein. In this study, we showed that SUMOylation of KLF4, is induced by IL-4 treatment in macrophages. IL4-induced KLF4 SUMOylation promotes RAW264.7 cells and bone marrow derived macrophages (BMDMs) to polarize into M2 subset. Thus, we identified an important post-translational modification (PTM), SUMOylation, plays a crucial role in regulating KLF4 activity during IL-4 induced macrophage M2 polarization. SUMOylation of KLF4 can be a potential therapeutic target in the resolution of inflammation.
DOI: 10.6084/m9.figshare.4524836.v1
title: SUMOylation of KLF4 promotes IL-4 induced macrophage M2 polarization

description: Macrophages, in response to different environmental cues, undergo the classical polarization (M1 macrophages) as well as the alternative polarization (M2 macrophages) that involve the functions of stimulus-specific transcription factors. Kruppel-like factor 4 (KLF4), a member of a subfamily of the zinc-finger class of DNA-binding transcription factors, plays as a critical regulator of macrophage polarization. KLF4 has been reported as a SUMOylated protein. In this study, we showed that SUMOylation of KLF4, is induced by IL-4 treatment in macrophages. IL4-induced KLF4 SUMOylation promotes RAW264.7 cells and bone marrow derived macrophages (BMDMs) to polarize into M2 subset. Thus, we identified an important post-translational modification (PTM), SUMOylation, plays a crucial role in regulating KLF4 activity during IL-4 induced macrophage M2 polarization. SUMOylation of KLF4 can be a potential therapeutic target in the resolution of inflammation.
DOI: 10.6084/m9.figshare.4537592
title: Loss of ULK1 increases RPS6KB1-NCOR1 repression of NR1H/LXR-mediated <i>Scd1</i> transcription and augments lipotoxicity in hepatic cells

description: Lipotoxicity caused by saturated fatty acids (SFAs) induces tissue damage and inflammation in metabolic disorders. SCD1 (stearoyl-coenzyme A desaturase 1) converts SFAs to mono-unsaturated fatty acids (MUFAs) that are incorporated into triglycerides and stored in lipid droplets. SCD1 thus helps protect hepatocytes from lipotoxicity and its reduced expression is associated with increased lipotoxic injury in cultured hepatic cells and mouse models. To further understand the role of SCD1 in lipotoxicity, we examined the regulation of <i>Scd1</i> in hepatic cells treated with palmitate, and found that NR1H/LXR (nuclear receptor subfamily 1 group H) ligand, GW3965, induced <i>Scd1</i> expression and lipid droplet formation to improve cell survival. Surprisingly, ULK1/ATG1 (unc-51 like kinase) played a critical role in protecting hepatic cells from SFA-induced lipotoxicity via a novel mechanism that did not involve macroautophagy/autophagy. Specific loss of <i>Ulk1</i> blocked the induction of <i>Scd1</i> gene transcription by GW3965, decreased lipid droplet formation, and increased apoptosis in hepatic cells exposed to palmitate. Knockdown of ULK1 increased RPS6KB1 (ribosomal protein S6 kinase, polypeptide 1) signaling that, in turn, induced NCOR1 (nuclear receptor co-repressor 1) nuclear uptake, interaction with NR1H/LXR, and recruitment to the <i>Scd1</i> promoter. These events abrogated the stimulation of <i>Scd1</i> gene expression by GW3965, and increased lipotoxicity in hepatic cells. In summary, we have identified a novel autophagy-independent role of ULK1 that regulates NR1H/LXR signaling, <i>Scd1</i> expression, and intracellular lipid homeostasis in hepatic cells exposed to a lipotoxic environment.
DOI: 10.6084/m9.figshare.4537592.v1
title: Loss of ULK1 increases RPS6KB1-NCOR1 repression of NR1H/LXR-mediated <i>Scd1</i> transcription and augments lipotoxicity in hepatic cells

description: Lipotoxicity caused by saturated fatty acids (SFAs) induces tissue damage and inflammation in metabolic disorders. SCD1 (stearoyl-coenzyme A desaturase 1) converts SFAs to mono-unsaturated fatty acids (MUFAs) that are incorporated into triglycerides and stored in lipid droplets. SCD1 thus helps protect hepatocytes from lipotoxicity and its reduced expression is associated with increased lipotoxic injury in cultured hepatic cells and mouse models. To further understand the role of SCD1 in lipotoxicity, we examined the regulation of <i>Scd1</i> in hepatic cells treated with palmitate, and found that NR1H/LXR (nuclear receptor subfamily 1 group H) ligand, GW3965, induced <i>Scd1</i> expression and lipid droplet formation to improve cell survival. Surprisingly, ULK1/ATG1 (unc-51 like kinase) played a critical role in protecting hepatic cells from SFA-induced lipotoxicity via a novel mechanism that did not involve macroautophagy/autophagy. Specific loss of <i>Ulk1</i> blocked the induction of <i>Scd1</i> gene transcription by GW3965, decreased lipid droplet formation, and increased apoptosis in hepatic cells exposed to palmitate. Knockdown of ULK1 increased RPS6KB1 (ribosomal protein S6 kinase, polypeptide 1) signaling that, in turn, induced NCOR1 (nuclear receptor co-repressor 1) nuclear uptake, interaction with NR1H/LXR, and recruitment to the <i>Scd1</i> promoter. These events abrogated the stimulation of <i>Scd1</i> gene expression by GW3965, and increased lipotoxicity in hepatic cells. In summary, we have identified a novel autophagy-independent role of ULK1 that regulates NR1H/LXR signaling, <i>Scd1</i> expression, and intracellular lipid homeostasis in hepatic cells exposed to a lipotoxic environment.
DOI: 10.6084/m9.figshare.4542754
title: The diagnostic value of confocal laser endomicroscopy for gastric cancer and precancerous lesions among Asian population: a system review and meta-analysis

description: <b>Objective:</b> The objective of this study is to evaluate the diagnostic value of confocal laser endomicroscopy (CLE) in detection of gastric cancer (GC), gastric intraepithelial metaplasia (GIM), and gastric intraepithelial neoplasia (GIN) lesions. <b>Method:</b> PubMed, the Cochrane Library, and Wangfang databases were searched to include eligible articles about CLE in detection of gastric lesions. After study selection, quality assessment and data extraction conducted by two reviewers independently, meta-analysis was performed by Meta-Disc 1.4. The pooled sensitivity and specificity was calculated, receiver operating characteristic (ROC) curve was constructed, and the area under ROC curve (AUC) was calculated. <b>Results:</b> Twenty-three studies evaluating the diagnostic value of CLE were included. For the diagnosis of GC lesions, the pooled sensitivity, specificity, and AUC were 91% (88–94%), 99% (99–99%), and 0.9513, respectively. For the diagnosis of lesions, the pooled sensitivity, specificity, and AUC were 92% (90–94%), 97% (96–98%), and 0.9774, respectively. For the diagnosis of GIN lesions, the pooled sensitivity, specificity and AUC were 81% (75–85%), 98% (97–98%), and 0.9204, respectively. <b>Conclusions:</b> CLE can provide an accurate diagnosis with high sensitivity and specificity for GC, GIM, and GIN lesions. The results should be confirmed by well-designed, multi-centered, randomized controlled, and double blinded trials with large samples.
DOI: 10.6084/m9.figshare.4542754.v1
title: The diagnostic value of confocal laser endomicroscopy for gastric cancer and precancerous lesions among Asian population: a system review and meta-analysis

description: <b>Objective:</b> The objective of this study is to evaluate the diagnostic value of confocal laser endomicroscopy (CLE) in detection of gastric cancer (GC), gastric intraepithelial metaplasia (GIM), and gastric intraepithelial neoplasia (GIN) lesions. <b>Method:</b> PubMed, the Cochrane Library, and Wangfang databases were searched to include eligible articles about CLE in detection of gastric lesions. After study selection, quality assessment and data extraction conducted by two reviewers independently, meta-analysis was performed by Meta-Disc 1.4. The pooled sensitivity and specificity was calculated, receiver operating characteristic (ROC) curve was constructed, and the area under ROC curve (AUC) was calculated. <b>Results:</b> Twenty-three studies evaluating the diagnostic value of CLE were included. For the diagnosis of GC lesions, the pooled sensitivity, specificity, and AUC were 91% (88–94%), 99% (99–99%), and 0.9513, respectively. For the diagnosis of lesions, the pooled sensitivity, specificity, and AUC were 92% (90–94%), 97% (96–98%), and 0.9774, respectively. For the diagnosis of GIN lesions, the pooled sensitivity, specificity and AUC were 81% (75–85%), 98% (97–98%), and 0.9204, respectively. <b>Conclusions:</b> CLE can provide an accurate diagnosis with high sensitivity and specificity for GC, GIM, and GIN lesions. The results should be confirmed by well-designed, multi-centered, randomized controlled, and double blinded trials with large samples.
DOI: 10.6084/m9.figshare.4545052
title: Combination of adalimumab with lower dose of methylprednisolone in Erdheim-Chester disease with systemic involvement

description: Combination of adalimumab with lower dose of methylprednisolone in Erdheim-Chester disease with systemic involvement
DOI: 10.6084/m9.figshare.4545052.v1
title: Combination of adalimumab with lower dose of methylprednisolone in Erdheim-Chester disease with systemic involvement

description: Combination of adalimumab with lower dose of methylprednisolone in Erdheim-Chester disease with systemic involvement
DOI: 10.6084/m9.figshare.4556194
title: Subduction initiation and ophiolite crust: new insights from IODP drilling

description: International Ocean Discovery Program (IODP) Expedition 352 recovered a high-fidelity record of volcanism related to subduction initiation in the Bonin fore-arc. Two sites (U1440 and U1441) located in deep water nearer to the trench recovered basalts and related rocks; two sites (U1439 and U1442) located in shallower water further from the trench recovered boninites and related rocks. Drilling in both areas ended in dolerites inferred to be sheeted intrusive rocks. The basalts apparently erupted immediately after subduction initiation and have compositions similar to those of the most depleted basalts generated by rapid sea-floor spreading at mid-ocean ridges, with little or no slab input. Subsequent melting to generate boninites involved more depleted mantle and hotter and deeper subducted components as subduction progressed and volcanism migrated away from the trench. This volcanic sequence is akin to that recorded by many ophiolites, supporting a direct link between subduction initiation, fore-arc spreading, and ophiolite genesis.
DOI: 10.6084/m9.figshare.4556194.v1
title: Subduction initiation and ophiolite crust: new insights from IODP drilling

description: International Ocean Discovery Program (IODP) Expedition 352 recovered a high-fidelity record of volcanism related to subduction initiation in the Bonin fore-arc. Two sites (U1440 and U1441) located in deep water nearer to the trench recovered basalts and related rocks; two sites (U1439 and U1442) located in shallower water further from the trench recovered boninites and related rocks. Drilling in both areas ended in dolerites inferred to be sheeted intrusive rocks. The basalts apparently erupted immediately after subduction initiation and have compositions similar to those of the most depleted basalts generated by rapid sea-floor spreading at mid-ocean ridges, with little or no slab input. Subsequent melting to generate boninites involved more depleted mantle and hotter and deeper subducted components as subduction progressed and volcanism migrated away from the trench. This volcanic sequence is akin to that recorded by many ophiolites, supporting a direct link between subduction initiation, fore-arc spreading, and ophiolite genesis.
DOI: 10.34658/rdb.8pks7d/bq8whh
title: GC_NiFe(C)-red.600_2.dat

description: GC chromatogram of Ni-Fe catalyst reduced 600C
DOI: 10.34658/rdb.8pks7d/swj07j
title: GC_NiFe(C)-red.200_3.dat

description: GC chromatogram of Ni-Fe catalyst reduced 200C
DOI: 10.34658/rdb.8pks7d/as1pg2
title: GC_NiFe(C)_r.300C.dat

description: GC chromatogram of Ni-Fe catalyst reduced 300C
DOI: 10.34658/rdb.8pks7d/sgbl0o
title: GC_NiFe(C)_red 400.dat

description: GC chromatogram of Ni-Fe catalyst reduced 400C
DOI: 10.34658/rdb.8pks7d/p9xc1v
title: GC_NiFe(S1).dat

description: GC chromatogram of Ni-Fe catalyst (S1)
DOI: 10.34658/rdb.8pks7d/ezyjk5
title: NiFe red 600 FTIR CO.tab

description: FTIR data of CO adsorption for NIFe catalyst red 600C
DOI: 10.34658/rdb.8pks7d/glgd6b
title: NiFe red 300 FTIR CO.tab

description: FTIR data of CO adsorption for NIFe catalyst red 300C
DOI: 10.34658/rdb.8pks7d/jt64bf
title: NiFe red 500 FTIR CO.tab

description: FTIR data of CO adsorption for NIFe catalyst red 500C
DOI: 10.34658/rdb.8pks7d/ukhy35
title: NiFe (S2) FTIR CO.tab

description: FTIR data of CO adsorption for NIFe catalyst (S2)
DOI: 10.34658/rdb.8pks7d/ctffju
title: NiFe red 200 FTIR CO.tab

description: FTIR data of CO adsorption for NIFe catalyst red 200C
DOI: 10.34658/rdb.8pks7d/f51mlu
title: NiFe (S1) FTIR CO.tab

description: FTIR data of CO adsorption for NIFe catalyst (S1)
DOI: 10.34658/rdb.8pks7d/cxsdke
title: NiFe red 400 FTIR CO.tab

description: FTIR data of CO adsorption for NIFe catalyst red 400C
DOI: 10.34658/rdb.8pks7d/zs1yfl
title: ToF-SIMS peak area.tab

description: ToF-SIMS data
DOI: 10.34658/rdb.8pks7d/dseozs
title: TPR Fe.tab

description: TPR file of Fe catalyst
DOI: 10.34658/rdb.8pks7d/1yrymt
title: TPR Ni-2.tab

description: TPR file of Ni catalyst
DOI: 10.34658/rdb.8pks7d/raigdw
title: TPR NiFe (S2).tab

description: TPR filie of NiFe(S2) catalyst
DOI: 10.34658/rdb.8pks7d/orbfga
title: TPR NiFe (S1).tab

description: TPR filie of NiFe(S1) catalyst
DOI: 10.34658/rdb.8pks7d/sor2dr
title: XRD NiFe (C) red 400.tab

description: XRD of the NiFe catalyst red400C
DOI: 10.6084/m9.figshare.4564792.v1
title: Comparative GMM and GQL logistic regression models on hierarchical data

description: We often rely on the likelihood to obtain estimates of regression parameters but it is not readily available for generalized linear mixed models (GLMMs). Inferences for the regression coefficients and the covariance parameters are key in these models. We presented alternative approaches for analyzing binary data from a hierarchical structure that do not rely on any distributional assumptions: a generalized quasi-likelihood (GQL) approach and a generalized method of moments (GMM) approach. These are alternative approaches to the typical maximum-likelihood approximation approach in Statistical Analysis System (SAS) such as Laplace approximation (LAP). We examined and compared the performance of GQL and GMM approaches with multiple random effects to the LAP approach as used in PROC GLIMMIX, SAS. The GQL approach tends to produce unbiased estimates, whereas the LAP approach can lead to highly biased estimates for certain scenarios. The GQL approach produces more accurate estimates on both the regression coefficients and the covariance parameters with smaller standard errors as compared to the GMM approach. We found that both GQL and GMM approaches are less likely to result in non-convergence as opposed to the LAP approach. A simulation study was conducted and a numerical example was presented for illustrative purposes.
DOI: 10.34658/rdb.8pks7d/qdvhnx
title: XRD NiFe (C) red 500.tab

description: XRD of the NiFe catalyst red500C
DOI: 10.34658/rdb.8pks7d/8ftu8w
title: XRD NiFe (C) red 300.tab

description: XRD of the NiFe catalyst red300C
DOI: 10.34658/rdb.8pks7d/qhmvns
title: XRD NiFe (C) red 600.tab

description: XRD of the NiFe catalyst red600C
DOI: 10.34658/rdb.8pks7d/vgwaoz
title: XRD NiFe (C) red 200.tab

description: XRD of the NiFe catalyst red200C
DOI: 10.6084/m9.figshare.4564972.v1
title: Silver nanoparticles induced reactive oxygen species via photosynthetic energy transport imbalance in an aquatic plant

description: The rapid growth in silver nanoparticles (AgNPs) commercialization has increased environmental exposure, including aquatic ecosystem. It has been reported that the AgNPs have damaging effects on photosynthesis and induce oxidative stress, but the toxic mechanism of AgNPs is still a matter of debate. In the present study, on the model aquatic higher plant <i>Spirodela polyrhiza</i>, we found that AgNPs affect photosynthesis and significantly inhibit Photosystem II (PSII) maximum quantum yield (<i>F</i><sub>v</sub>/<i>F</i><sub>m</sub>) and effective quantum yield (<i>Φ</i><sub>PSII</sub>). The changes of non-photochemical fluorescence quenching (NPQ), light-induced non-photochemical fluorescence quenching [Y(NPQ)] and non-light-induced non-photochemical fluorescence quenching [Y(NO)] showed that AgNPs inhibit the photo-protective capacity of PSII. AgNPs induce reactive oxygen species (ROS) that are mainly produced in the chloroplast. The activity of ribulose-1, 5-bisphosphate carboxylase–oxygenase (Rubisco) was also very sensitive to AgNPs. The internalized Ag, regardless of whether the exposure was Ag<sup>+ </sup>or AgNPs had the same capacity to generate ROS. Our results support the hypothesis that intra-cellular AgNP dissociate into high toxic Ag<sup>+</sup>. Rubisco inhibition leads to slowing down of CO<sub>2</sub> assimilation. Consequently, the solar energy consumption decreases and then the excess excitation energy promotes ROS generation in chloroplast.
DOI: 10.6084/m9.figshare.4564972
title: Silver nanoparticles induced reactive oxygen species via photosynthetic energy transport imbalance in an aquatic plant

description: The rapid growth in silver nanoparticles (AgNPs) commercialization has increased environmental exposure, including aquatic ecosystem. It has been reported that the AgNPs have damaging effects on photosynthesis and induce oxidative stress, but the toxic mechanism of AgNPs is still a matter of debate. In the present study, on the model aquatic higher plant <i>Spirodela polyrhiza</i>, we found that AgNPs affect photosynthesis and significantly inhibit Photosystem II (PSII) maximum quantum yield (<i>F</i><sub>v</sub>/<i>F</i><sub>m</sub>) and effective quantum yield (<i>Φ</i><sub>PSII</sub>). The changes of non-photochemical fluorescence quenching (NPQ), light-induced non-photochemical fluorescence quenching [Y(NPQ)] and non-light-induced non-photochemical fluorescence quenching [Y(NO)] showed that AgNPs inhibit the photo-protective capacity of PSII. AgNPs induce reactive oxygen species (ROS) that are mainly produced in the chloroplast. The activity of ribulose-1, 5-bisphosphate carboxylase–oxygenase (Rubisco) was also very sensitive to AgNPs. The internalized Ag, regardless of whether the exposure was Ag<sup>+ </sup>or AgNPs had the same capacity to generate ROS. Our results support the hypothesis that intra-cellular AgNP dissociate into high toxic Ag<sup>+</sup>. Rubisco inhibition leads to slowing down of CO<sub>2</sub> assimilation. Consequently, the solar energy consumption decreases and then the excess excitation energy promotes ROS generation in chloroplast.