DOI: 10.60645/bdc-38s4-7450
title: NHLBI Jackson Heart Study Candidate Gene Association Resource (CARe)

description: 
 

This sub-study [phs000499](http://./study.cgi?study_id=phs000499) JHS CARe contains genotype data of subjects available from the [phs000499](http://./study.cgi?study_id=phs000499) study. Summary level phenotypes for the NHLBI JHS Cohort study participants can be viewed at the top-level study page [phs000286](./study.cgi?study_id=phs000286) JHS Cohort. Individual level phenotype data and molecular data for all JHS Cohort top-level study and substudies are available by requesting Authorized Access to the NHLBI JHS Cohort [phs000286](./study.cgi?study_id=phs000286) study.



The [Jackson Heart Study](https://www.jacksonheartstudy.org/) (JHS) is a large, community-based, observational study whose participants were recruited from urban and rural areas of the three counties (Hinds, Madison and Rankin) that make up the Jackson, Mississippi, metropolitan statistical area (MSA). Participants were enrolled from each of 4 recruitment pools: random, 17%; volunteer, 30%; currently enrolled in the Atherosclerosis Risk in Communities (ARIC) Study, 22% and secondary family members, 31%. Recruitment was limited to non-institutionalized adult African Americans 35-84 years old, except in the family cohort where those 21 to 34 years of age were eligible. The final cohort of 5,301 participants includes 6.59% of all African American Jackson MSA residents aged 35-84 (N-76,426, US Census 2000). Major components of each exam include medical history, physical examination, blood/urine analytes and interview questions on areas such as: physical activity; stress, coping and spirituality; racism and discrimination; socioeconomic position; and access to health care. At 12-month intervals after the baseline clinic visit (Exam 1), participants are contacted by telephone to: update information; confirm vital statistics; document interim medical events, hospitalizations, and functional status; and obtain additional sociocultural information. Questions about medical events, symptoms of cardiovascular disease and functional status are repeated annually. Ongoing cohort surveillance includes abstraction of medical records and death certificates for relevant International Classification of Diseases (ICD) codes and adjudication of nonfatal events and deaths.

**NHLBI Candidate-gene Association Resource.** The NHLBI initiated the Candidate gene Association Resource (CARe) to create a shared genotype/phenotype resource for analyses of the association of genotypes with phenotypes relevant to the mission of the NHLBI. The resource comprises nine cohort studies funded by the NHLBI including: [Atherosclerosis Risk in Communities](https://www.nhlbi.nih.gov/science/atherosclerosis-risk-communities-aric-study) (ARIC), [Cardiovascular Health Study](https://www.nhlbi.nih.gov/science/cardiovascular-health-study-chs) (CHS), Cleveland Family Study (CFS), [Coronary Artery Risk Development in Young Adults](https://www.nhlbi.nih.gov/science/coronary-artery-risk-development-young-adults-study-cardia) (CARDIA), [Framingham Heart Study](https://www.nhlbi.nih.gov/science/framingham-heart-study-fhs) (FHS), [Jackson Heart Study](vhttps://www.jacksonheartstudy.org/) (JHS), [Multi-Ethnic Study of Atherosclerosis](https://www.mesa-nhlbi.org/) (MESA), and the [Sleep Heart Health Study](https://biolincc.nhlbi.nih.gov/studies/shhs/) (SHHS). A database of genotype and phenotype data was created that includes records for approximately 41,000 study participants with approximately 50,000 SNPs from more than 2,000 selected candidate genes. In addition, a genome wide association study (GWAS) using a 1,000K SNP Chip was conducted on approximately 8,900 African American participants drawn from five CARe cohorts: ARIC, CARDIA, CFS, JHS, and MESA. Data from individual cohorts is available to approved investigators through dbGaP.