cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.17639/nott.362
title: Psychological therapy interactions coding scheme (PICS) development data: PICS Manual 1.5

description: This manual should be read in conjunction with the following paper describing its development: The Development of an Observational Measure to Assess Patient Activation, Illustrated in Psychological Therapy with Long-Term High Users of Healthcare Who Have Complex Needs. The PICS manual gives a detailed description of a coding method for rating patient activation levels in psychological therapy interactions.
DOI: 10.17639/nott.361
title: Psychological therapy interactions coding scheme (PICS) development data: outcomes comparison

description: This dataset should be viewed alongside the accompanying paper: The Development of an Observational Measure to Assess Patient Activation, Illustrated in Psychological Therapy with Long-Term High Users of Healthcare Who Have Complex Needs. This dataset shows the PICS ratings for all participants averaged across all coders. Scores on all themes are combined to an average content/turns theme score and an average global theme score. Participants are ordered according to their scores, highest at the top lowest at the bottom. The outcomes achieved by each participant are also shown. Time point 1 is baseline, time point 2 is six month follow-up and the difference between scores is also shown.
DOI: 10.17639/nott.365
title: Raw data for new compounds described in the paper: "Remote Nucleophilic Allylation by Allylrhodium Chain Walking"

description: Raw data for new compounds described in the paper: "Remote Nucleophilic Allylation by Allylrhodium Chain Walking". Metal migration through a carbon chain is a versatile method for achieving remote functionalization. However, almost all known examples involve the overall net migration of alkylmetal species. Here, we report that allylrhodium species obtained from hydrorhodation of 1,3-dienes undergo chain walking toward esters, amides, or (hetero)arenes over distances of up to eight ethylene units. The final, more highly conjugated allylrhodium species undergo nucleophilic allylation with aldehydes and an imine to give Z-homoallylic alcohols and amines, respectively.
DOI: 10.17639/nott.6173
title: Modelling the long-term suspended sedimentological effects on stormwater pond performance in an urban catchment

description: The influence of long-term suspended sediment dynamics on stormwater pond performance is not negligible, but often neglected in pond design and performance evaluation. This paper provides systematic simulated quantification of long-term suspended sedimentological effects on stormwater pond performance. Integrated hydrological and two-dimensional hydro-morphodynamic modelling and simulations were carried out over a 32-year-period (1984-2015) covering 3896 rainfall events with a wide range of rainfall volumes, durations and intensities. Three event-based hypothetical rainfall scenarios; non-flood condition (5-year), sewer design condition (30-year), and river flood condition (100-year) rainfall events with 1-hr duration were also simulated for comparison between the traditional event-based approach and the novel approach presented in this study. Simulation results show that the flood peak attenuation and delay are more pronounced for small (&lt; 5-year) and medium (&lt; 30-year) flood events. The long-term continuous simulation results indicate that the pond provides positive annual trap efficiencies varying from 2% to 69% for 31 of 32 years, providing long term water quality benefits downstream. However, rainfall events in year 2012 flushed out the accumulated sedimentation as a shock load to the downstream river, leading to a negative trap efficiency of -11%. The spatially averaged sediment deposition rate, as predicted by the model, varies with a mean of 2 (1.34) cm/year over the study period, which resulted in a 24% loss in the pond’s volume over 32 years. The impacts of the loss in storage on pond flood attenuation capacity are explored at regular time intervals over the study period. The results indicate that reduction in the pond’s flood attenuation capacity is relatively more pronounced for medium (30-year) and extreme (100-year) flood events than the frequent small flood (5- year) events. The variation in annual sediment loading with rainfall quantities and patterns are also explored.
DOI: 10.17639/nott.42
title: Age-related changes to human stratum corneum lipids detected using ToF-SIMS following in vivo sampling

description: This work demonstrates the ability to detect changes in both quantity and spatial distribution of human stratum corneum (SC) lipids from samples collected in vivo. The SC functions as the predominant barrier to the body, protecting against the penetration of xenobiotic substances. Changes to the SC lipid composition have been associated with barrier impairment and consequent skin disorders and it is therefore important to monitor and quantify changes to this structure. This work demonstrates the first reported use of time of flight secondary ion mass spectrometry (ToF-SIMS) to assess physiological changes to human SC as a function of depth. This technique provides exceptional sensitivity and chemical specificity, allowing analysis of single tape stripped samples taken from volunteers. Using this methodology we were able to successfully identify chemical differences in human SC resulting from both intrinsic and extrinsic (photo) aging. Samples were collected from women of two age groups (under 27 and post-menopausal) and from two body sites with varying UV exposure (inner forearm and dorsal hand) and differences were identified using multivariate data analysis. The key finding was the significant aged-related increase and change in spatial distribution of the sterol cholesterol sulfate, a membrane stabilizing lipid. Significant changes in the prevalence of both lignoceric acid (C24:0) and hexacosanoic acid (C26:0) were also observed. This work describes previously unreported age-related chemical changes to human SC, providing an insight into aging mechanisms which may improve the design of both pharmaceutical and cosmetic topical products.
DOI: 10.17639/nott.44
title: Quantum confinement and photoresponsivity of β-In2Se3 nanosheets grown by physical vapour transport

description: We demonstrate that β-In2Se3 layers with thickness ranging from 2.8 – 100 nm can be grown on SiO2/Si, mica and graphite using a physical vapour transport method. The β-In2Se3 layers are chemically stable at room temperature and exhibit a blue-shift of the photoluminescence emission when the layer thickness is reduced, due to strong quantum confinement of carriers by the physical boundaries of the material. The layers are characterized using Raman spectroscopy and X-ray diffraction from which we confirm lattice constants c = 28.310.05 Å and a = 3.990.02 Å. In addition, these layers show high photoresponsivity of up to ~ 2×103 A/W at a wavelength of 633 nm, with rise and decay times of 0.6 ms and 2.5 ms, respectively, confirming the potential of the as-grown layers for high sensitivity, fast photodetectors.
DOI: 10.17639/nott.56
title: In vitro lipolysis/microsomal metabolism approach for the prediction of oral bioavailability of BCS II drugs in lipidic formulations

description: Lipidic formulations (LFs) are increasingly utilized for the delivery of drugs that belong to class II of the Biopharmaceutics Classification System (BCS). The current work proposes, for the first time, the combination of in vitro lipolysis and microsomal metabolism studies for the quantitative prediction of human oral bioavailability of BCS II drugs administered in LFs. Marinol® and Neoral® were selected as model LFs and their observed oral bioavailabilities (Fobserved) obtained from published clinical studies in humans. Two separate lipolysis buffers, differing in the level of surfactant concentrations, were used for digestion of the LFs. The predicted fraction absorbed (Fabs) was calculated by measuring the drug concentration in the micellar phase after completion of the lipolysis process. To determine first-pass metabolism (Fg∙Fh), drug depletion studies with human microsomes were performed. Clearance values were determined by applying the “in vitro half-life approach”. The estimated Fabs and Fg∙Fh values were combined for the calculation of the predicted oral bioavailability (Fpredicted). Results showed that there was a strong correlation between Fobserved and Fpredicted values only when Fabs was calculated using a buffer with surfactant concentrations closer to physiological conditions. The general accuracy of the predicted values suggests that the novel in vitro lipolysis/metabolism approach could quantitatively predict the oral bioavailability of lipophilic drugs administered in LFs.
DOI: 10.17639/nott.45
title: Illness beliefs predict mortality in patients with diabetic foot ulcers

description: Background: Patients’ illness beliefs have been associated with glycaemic control in diabetes and survival in other conditions. Objective: We examined whether illness beliefs independently predicted survival in patients with diabetes and foot ulceration. Methods: Patients (n=169) were recruited between 2002 and 2007. Data on illness beliefs were collected at baseline. Data on survival were extracted on 1st November 2011. Number of days survived reflected the number of days from date of recruitment to 1st November 2011. Results: Cox regressions examined the predictors of time to death and identified ischemia and identity beliefs (beliefs regarding symptoms associated with foot ulceration) as significant predictors of time to death. Conclusions: Our data indicate that illness beliefs have a significant independent effect on survival in patients with diabetes and foot ulceration. These findings suggest that illness beliefs could improve our understanding of mortality risk in this patient group and could also be the basis for future therapeutic interventions to improve survival.
DOI: 10.17639/nott.47
title: Organisation and ordering of 1D porphyrin polymers synthesised by on-surface Glaser coupling

description: One-dimensional polymer chains consisting of π-conjugated porphyrin units are formed via Glaser coupling on a Ag(111) surface. Scanning probe microscopy reveals the covalent structure of the products and their ordering. The conformational flexibility within the chains is investigated via a comparison of room temperature and cryogenic measurements.
DOI: 10.17639/nott.7030
title: Resonant tunnelling into the two-dimensional subbands of InSe layers

description: Two-dimensional (2D) van der Waals (vdW) crystals have attracted considerable interest for digital electronics beyond Si-based complementary metal oxide semiconductor technologies. Despite the transformative success of Si-based devices, there are limits to their miniaturization and functionalities. Here we realize resonant tunnelling transistors (RTTs) based on a 2D InSe layer sandwiched between two multi-layered graphene (MLG) electrodes. In these RTTs the energy of the quantum-confined 2D subbands of InSe can be tuned by the thickness of the InSe layer. By applying a voltage across the two MLG electrodes, which serves as the source and drain electrodes to the InSe layer, the chemical potential in the source can be tuned in and out of resonance with a given 2D subband, leading to multiple regions of negative differential conductance (NDC) that can be tuned by electrostatic gating. This work demonstrates the potential of 2D InSe and InSe-based RTTs for applications in quantum electronics.
DOI: 10.17639/nott.7032
title: Vaccine NMA data & syntax

description: Psychological and behavioural factors influence the effectiveness of vaccines. This has led to interest in the potential for non-pharmacological treatments, which modify these factors, to enhance vaccine effectiveness. We conducted a systematic review and network meta-analysis (NMA) to examine the effects of non-pharmacological adjuvants on vaccine effectiveness, as measured by antibody responses to vaccination. Electronic databases (EMBASE, Medline, PsychINFO, CINAHL) were searched from inception to 6th February 2018. This yielded 100 eligible papers, reporting 106 trials: 79 interventions associated with diet and/or nutrition; 12 physical activity interventions and 9 psychological interventions. We observed that over half of all trials (k=58/106 trials) reported evidence of non-pharmacological interventions enhancing the antibody response to vaccination across one or more outcomes. The NMA considered the evidence for the effects of all intervention types compared with placebo on antibody titres (k=48 studies), seroconversion (k=25 studies) and seroprotection (k=23 studies) separately. The NMA provided weak evidence in support of nutritional formulae and probiotics in increasing antibody titres. This literature provides early evidence of nutritional formulae and probiotic interventions being associated with enhanced antibody responses to vaccination. The absence of evidence for other treatments is likely to be the consequence of limited and unreliable evidence on these treatments.
DOI: 10.17639/nott.7063
title: Influence of water deficit on root and shoot growth in wheat

description: none
description: Meta data to support the publication 'Quantifying the influence of water deficit on root and shoot growth in wheat using X-ray Computed Tomography' In AOBPlants
DOI: 10.17639/nott.7064
title: Losing her voice premiere audience dataset

description: This dataset includes all anonymised audience data from the premiere of Losing Her Voice, a contemporary opera composed and written by Elizabeth Kelly (University of Nottingham), which involved the use of a custom web app on their phones by audience members.
DOI: 10.17639/nott.6484
title: An in vivo systematic genetic analysis of tumour progression in Drosophila - RNAi line: 3937R2

description: This data set forms part of the larger 'Fly Cancer Screen' data set, which consists of over 700 image sets
description: Metastasis is the leading cause of death for cancer patients. Consequently it is imperative that we improve our understanding of the molecular mechanisms that underlie progression of tumour growth towards malignancy. Advances in genome characterisation technologies have been very successful in identifying commonly mutated or misregulated genes in a variety of human cancers. A major challenge however is the translation of these findings to new biological insight due to the difficulty in evaluating whether these candidate genes drive tumour progression. Using the genetic amenability of Drosophila melanogaster we generated tumours with specific genotypes in the living animal and carried out a detailed systematic loss-of-function analysis to identify numerous conserved genes that enhance or suppress epithelial tumour progression. This enabled the discovery of functional cooperative regulators of invasion and the establishment of a network of conserved ‘invasion suppressors’. RNAi line: 3937R2 (III) Source: NIG Name: cher Full name: cheerio Also known as: sko, FLN, FLN90 Annotation symbol: CG3937 FlyBase ID: FBgn0014141 File naming convention: File names typically contain representations of date (DDMMYY), RNAi Line, Animal Number and, in some cases, window (to accommodate larger samples that require multiple image stacks)
DOI: 10.17639/nott.7029
title: Raw data and analysis for paper 'Use of Surface Motion Characteristics Determined by InSAR to Assess Peatland Condition'

description: Raw and processed ISBAS DInSAR data for 22 sites across the Flow Country NE Scotland corresponding to the paper 'Use of Surface Motion Characteristics Determined by InSAR to Assess Peatland Condition'. Twenty-two study sites each covered by 2 to 6 ISBAS pixels, were selected in the Flow Country, northern Scotland (centered on 58.371478N, 3.658447W), the largest blanket bog in Europe, to cover a spectrum of peatland conditions. The sites are widely dispersed over a 1200 km2 area, range in altitude from 100 to 400m above sea level and have varied hydrological setting and management histories. Two complementary approaches were taken to site selection: 15 sites were chosen to cover a range of average surface motion (in m/year) as had been measured using the ISBAS method over a 21 month period - March 2015 – December 2016 in Alshammari et al. [2018]; 7 sites were chosen on account of having existing detailed field measures of peatland condition. Continuous water level data was available for three of the sites - where it had been recorded every 30 minutes along with water temperature with Orpheus mini data loggers. Supporting this vegetation survey was a cloud-free Sentinel-2 Multispectral Instrument (MSI) image. Of these 22 study sites, 12 study sites were visited over a period of 7 days in the peak of the growing season in 2017. At each of those 12 study sites, 4-6 survey locations were randomly selected. At each survey location, a 10m x 10m square was centered on the GPS coordinate of the spatially coincident Sentinel-2 pixel and the four sides of each square were aligned with the cardinal points, thus in the same orientation as the Sentinel-2 pixels. In each of the 10 x 10m square, the percent cover of key plant functional types (Sphagnum mosses, other mosses, lichen, ericaceous shrubs, sedges, grasses, trees) as well as key features associated with peatland condition and with the potential to influence the spectral signature of the Sentinel-2 data (bare peat, open water and vegetation litter/brash) were noted. For each functional group identified, dominant species were also noted. Each square was photographed from the South-East corner, facing North and vegetation patterns reflecting density and spread of dominant plant functional groups were drawn and annotated for future reference. For each site, general condition was further assessed by noting the presence of drains, tracks, evidence of deer trampling or browsing, presence of natural pools, restoration activity, andestimating distance to road, forestry or infrastructure within a 100m x 100m area around the groups of squares. Land-use history was documented by discussion with land-owners.
DOI: 10.17639/nott.6571
title: An in vivo systematic genetic analysis of tumour progression in Drosophila - RNAi line: 27039

description: This data set forms part of the larger 'Fly Cancer Screen' data set, which consists of over 700 image sets
description: Metastasis is the leading cause of death for cancer patients. Consequently it is imperative that we improve our understanding of the molecular mechanisms that underlie progression of tumour growth towards malignancy. Advances in genome characterisation technologies have been very successful in identifying commonly mutated or misregulated genes in a variety of human cancers. A major challenge however is the translation of these findings to new biological insight due to the difficulty in evaluating whether these candidate genes drive tumour progression. Using the genetic amenability of Drosophila melanogaster we generated tumours with specific genotypes in the living animal and carried out a detailed systematic loss-of-function analysis to identify numerous conserved genes that enhance or suppress epithelial tumour progression. This enabled the discovery of functional cooperative regulators of invasion and the establishment of a network of conserved ‘invasion suppressors’. RNAi line: 27039 (III) Source: Bloomington Name: Ephrin (2) Full name: Ephrin Also known as: lincRNA.922 Annotation symbol: CG1862 FlyBase ID: FBgn0040324 File naming convention: File names typically contain representations of date (DDMMYY), RNAi Line, Animal Number and, in some cases, window (to accommodate larger samples that require multiple image stacks)
DOI: 10.17639/nott.358
title: Moiré-modulated conductance of hexagonal boron nitride tunnel barriers

description: Monolayer hexagonal boron nitride (hBN) tunnel barriers investigated using conductive atomic force microscopy reveal moiré patterns in the spatial maps of their tunnel conductance consistent with the formation of a moiré superlattice between the hBN and an underlying highly ordered pyrolytic graphite (HOPG) substrate. This variation is attributed to a periodic modulation of the local density of states and occurs for both exfoliated hBN barriers and epitaxially-grown layers. The epitaxial barriers also exhibit enhanced conductance at localised sub-nanometre regions which are attributed to exposure of the substrate to a nitrogen plasma source during the high temperature growth process. Our results show clearly a spatial periodicity of tunnel current due to the formation of a moiré superlattice and we argue that this can provide a mechanism for elastic scattering of charge carriers for similar interfaces embedded in graphene/hBN resonant tunnel diodes.
DOI: 10.17639/nott.7070
title: In situ protein identification, mapping and depth profiling using 3D OrbiSIMS

description: Label-free protein characterisation at surfaces requires digestion or matrix application prior to mass spectrometry. We report the assignment of undigested proteins at surfaces using secondary ion mass spectrometry (SIMS). Ballistic fragmentation induced by a gas cluster ion beam (GCIB) produces peptide fragments for subsequent OrbitrapTM analysis. We annotate 16 example proteins (up to 272 kDa) by de novo sequencing and apply the methodology to characterising a protein monolayer biochip and in situ depth profiling of proteins through human skin.
DOI: 10.17639/nott.7071
title: Single cell tracking on polymer microarray reveals the impact of surface chemistry on Pseudomonas aeruginosa twitching speed and biofilm development

description: Dataset contains raw and processed data used for the creation of figures in publication entitled 'Single cell tracking on polymer microarray reveals the impact of surface chemistry on Pseudomonas aeruginosa twitching speed and biofilm development'.
DOI: 10.17639/nott.7028
title: Numerical data for publication "Tracking the Consumption of Home Essentials"

description: This spreadsheet contains the data used for the statistical analysis for the ACM CHI 2019 paper "Tracking the Consumption of Home Essentials". This work was published by the Association of Computing Machinery and presented at the 2019 CHI Conference on Human Factors in Computing Systems in Glasgow, UK. DOI: 10.1145/3290605.3300869
DOI: 10.17639/nott.6980
title: An in vivo systematic genetic analysis of tumour progression in Drosophila - RNAi line: 15288R-3

description: This data set forms part of the larger 'Fly Cancer Screen' data set, which consists of over 700 image sets
description: Metastasis is the leading cause of death for cancer patients. Consequently it is imperative that we improve our understanding of the molecular mechanisms that underlie progression of tumour growth towards malignancy. Advances in genome characterisation technologies have been very successful in identifying commonly mutated or misregulated genes in a variety of human cancers. A major challenge however is the translation of these findings to new biological insight due to the difficulty in evaluating whether these candidate genes drive tumour progression. Using the genetic amenability of Drosophila melanogaster we generated tumours with specific genotypes in the living animal and carried out a detailed systematic loss-of-function analysis to identify numerous conserved genes that enhance or suppress epithelial tumour progression. This enabled the discovery of functional cooperative regulators of invasion and the establishment of a network of conserved ‘invasion suppressors’. RNAi line: 15288R-3 (III) Source: NIG Name: wb (2) Full name: wing blister Also known as: l(2)br1, BG:DS03792 .2, l(2)34Fb, BG:DS03792 .1, A1 Annotation symbol: CG42677 FlyBase ID: FBgn0261563 File naming convention: File names typically contain representations of date (DDMMYY), RNAi Line, Animal Number and, in some cases, window (to accommodate larger samples that require multiple image stacks)