cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.27270306.v3
title: <b>Figure 4. Activation of innate immune signaling induces HSV-1 reactivation from latent infection.</b>

description: 4A-E. Neurons latently infected with Stayput-GFP were treated with ligands for the DNA/RNA sensing pathways: <br>4A. Number of Us11-GFP expressing neurons at 2 days post treatment with; Mock (not treated), LY294002 (20μM) and DMXAA (50 μg/mL). <br>4B. Number of Us11-GFP expressing neurons at 2 days post treatment with; Mock (not treated), LY294002 (20μM) and ADU-S100 (10 μg/mL).<br>4C. Number of Us11-GFP expressing neurons at 2 days post treatment with; Mock (not treated), LY294002 (20μM) and Poly(dA-dT)/LyoVec (5 μg/mL).  <br>4D. Number of Us11-GFP expressing neurons at 2 days post treatment with; Mock (not treated), LY294002 (20μM) and ISD (5μg/mL; D) <br>4E. Number of Us11-GFP expressing neurons at 2 days post treatment with; Mock (not treated), LY294002 (20μM), Poly(I:C) (HMW), or Poly(I:C) (LMW) (10 μg/mL).<br>4F. Number of Us11-GFP expressing neurons at 2 days post co-infection or Mock (not treated). Neurons latently infected with Stayput-GFP were co-infected with the HCoV-OC43 at an MOI of 3 PFU/cell.4G. Number of Us11-GFP expressing neurons at 2 days post treatment with; Mock (not treated), DMXAA (50 μg/mL) and DMXAA (50 μg/mL) + GNE-3511(4 μΜ). Neurons latently infected with Stayput-GFP were reactivated with DMXAA in the presence or absence of the DLK inhibitor GNE-3511 (4 μΜ).  4H. Relative expression of <i>ICP27</i> mRNA quantified by RT-qPCR at 18 hours post-reactivation (Phase I). Neurons latently infected with KOS-SPA and KOS-UL98 were treated with either LY294002 or DMXAA or LY294002, followed 2.5 hours later by DMXAA.
DOI: 10.6084/m9.figshare.24224101.v1
title: Supplementary Material for: PHOCUS: A Phase 3, Randomized, Open-Label Study of Sequential Treatment with Pexa-Vec (JX-594) and Sorafenib in Patients with Advanced Hepatocellular Carcinoma

description: Introduction Intratumoral administration of pexa-vec (Pexastimogene Devacirepvec), an oncolytic and immunotherapeutic vaccinia virus. given to patients with hepatocellular carcinoma (HCC), is associated with both local and distant tumor responses. We hypothesized subsequent treatment with sorafenib could demonstrate superior efficacy. Methods This random phase III open-label study evaluated the sequential treatment with pexa-vec followed by sorafenib compared to sorafenib in patients with advanced HCC and no prior systemic treatment. The primary endpoint is overall survival (OS). Key secondary endpoints included time to progression (TTP), progression-free survival (PFS), overall response rate (ORR), and disease control rate (DCR). Safety was assessed in all patients who received ≥ 1 dose of study treatment. Results The study was conducted at 142 sites in 16 countries. From December 30, 2015, to the interim analysis on August 2, 2019, 459 patients were randomly assigned (pexa-vec plus sorafenib 234, sorafenib: 225). At the interim analysis the median OS was 12.7 months (95% CI: 9.89, 14.95) in the pexa-vec plus sorafenib arm and 14.0 months (95% CI: 11.01, 18.00) in the sorafenib arm. This led to early termination of the study. The median TTP was 2.0 months (95% CI: 1.77, 2.96) and 4.2 months (95% CI: 2.92, 4.63); ORR was 19.2% (45 patients) and 20.9% (47 patients); and DCR was 50.0% (117 patients) and 57.3% (129 patients) in the pexa-vec plus sorafenib and sorafenib arms, respectively. Serious adverse events were reported in 117 (53.7%) patients in the pexa-vec plus sorafenib and 77 (35.5%) patients in the sorafenib arm. Liver failure was the most frequently reported in both groups. Discussion/Conclusion Sequential pexa-vec plus sorafenib treatment did not demonstrate increased clinical benefit in advanced HCC and fared worse compared to sorafenib alone. The advent of the added value of checkpoint inhibitors should direct any further development of oncolytic virus therapy strategies.
DOI: 10.6084/m9.figshare.25814404.v1
title: Supplementary materials

description: This data is supplementary to the master's thesis on Horizon scanning of potential new alien vascular plant species and their climatic niche space in the Arctic.
DOI: 10.6084/m9.figshare.7942781.v1
title: gVCF_NA12843

description: 1000 Genomes gVCF mapped to hs37d5 for NA12843. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.17632/sf2h83t8v3
title: Chemical datasets of environmental samples (2019) from the Doce River Basin, Brazil

description: Environmental samples of the Doce River were analyzed to quantify inorganic and organic contaminants in the water and sediments obtained in two field surveys in 2019 (wet and dry seasons), in eight different sampling sites (triplicate samples) along the Doce River Basin. Additionally, tables summarizing chemical data and physicochemical parameters reported by the literature, from samples obtained until 2019, are also provided. The datasets provided herein will be helpful in understanding the potential impacts of multiple sources of contamination combined with a major environmental disaster in 2015.
Two sampling sites at the Upper Doce River Basin (more influenced by mining activities): GUA (Gualaxo do Norte) and CAN (Candonga); three at the Middle Doce River Basin (more impacted by industrial and domestic wastewater): NAQ (Naque), REF (Reference site at Corrente Grande River) and GOV (Governador Valadares); and three at the Lower Docer River Basin (under influence of agricultural activities in addition to domestic and industrial wastewater): AIM (Aimores); COL (Colatina) and LIN (Linhares).
DOI: 10.6084/m9.figshare.5125252.v1
title: Supplementary Material for: Adult and Near-Adult Height in Patients with Severe Insulin-Like Growth Factor-I Deficiency after Long-Term Therapy with Recombinant Human Insulin-Like Growth Factor-I

description: <b><i>Background:</i></b> Treatment with recombinant human insulin-like growth factor-I (IGF-I) stimulates linear growth in children with severe IGF-I deficiency (IGFD). <b><i>Aims:</i></b> To evaluate the efficacy and safety of treatment with IGF-I in patients with severe IGFD treated until adult or near-adult height. <b><i>Methods:</i></b> Twenty-one children with severe IGFD were treated until adult or near-adult height under a predominantly open-label design. All patients were naive to IGF-I. Recombinant human IGF-I was administered subcutaneously in doses between 60 and 120 µg/kg twice daily. Nine patients received additional therapy with gonadotropin- releasing hormone (GnRH) analog for a mean period of 2.9 ± 1.8 years. <b><i>Results:</i></b> Mean duration of treatment was 10.0 years. Mean height velocity increased from 3.1 cm/year prior to treatment to 7.4 cm/year during the first year of treatment. Height velocities during the subsequent years were lower, but remained above baseline for up to 12 years. Cumulative mean Δ height SD score at (near) adult height was +2. The observed mean gain in height was 13.4 cm more than had been expected without treatment. The adult height achieved by the patients also treated with GnRH analog was not different from those who received IGF-I therapy alone. There were no new safety signals identified in these patients, a subset of those previously reported. <b><i>Conclusion:</i></b> Long-term therapy with IGF-I improves adult height of patients with severe IGFD. Most patients did not bring their heights into the normal adult range.
DOI: 10.6084/m9.figshare.28877858.v1
title: TableS1, 2.xlsx

description: Average mineral compositions of gabbroic rocks from the previous studies of the Tiger Gabbro Complex.Bulk-rock geochemical and Sr-Nd isotopic compositions of gabbroic samples in the previous studies.
DOI: 10.6084/m9.figshare.3487319.v1
title: Impact of gonadectomy on blood pressure regulation in ageing male and female rats

description: Data points corresponding to the Figures submitted for "Impact of gonadectomy on blood pressure regulation in ageing male and female rats" manuscript
DOI: 10.6084/m9.figshare.101044.v1
title: Hertzprung-Russel Diagram

description: This is a Hertzprung-Russel diagram showing stellar absolute magnitude (how luminous a star is) versus "color-magnitude" (B-V; how red or blue a star is). Stellar data from the HIPPARCOS (black dots) and Gliese (gray dots) catalogues were used. Thus this HR diagram is biased toward nearby (Gliese) or bright (HIPPARCOS) stars. The color bar indicates temperature in units of 10^3 Kelvin. The Main Sequence and Giant Branch are indicated, as well as the primary stars of interest for the Trinity College Dublin (Ireland) Astrophysics Research Group (the Sun, Betelgeuse and EG Andromeda). As you can see, the Sun is quite an average star. This diagram will be published in my PhD thesis (Higgins, 2012; submitted).
DOI: 10.6084/m9.figshare.7091897.v1
title: Supplemental Data File 2 from Expression of a novel surfactant protein gene is associated with sites of extrapulmonary respiration in a lungless salamander

description: A FASTA amino acid alignment used to generate the gene tree.
DOI: 10.6084/m9.figshare.10334927.v3
title: Supporting data of the manuscript entitled “Study on neuropathological mechanisms of primary monosymptomatic nocturnal enuresis in children using cerebral resting-state functional magnetic resonance imaging”

description: The fMRI data generated for the study include 54 figures (PMNE group: 37 figures; control group: 17 figures). These data were analyzed with ALFF, ReHo and seed-based FC, respectively. Detailed demographic data of the PMNE group and control group were listed (Supplementary Tables S1 and S2). The raw data of ALFF and ReHo extracted from the significantly different brain regions between the two groups were also shown as Supplementary Information files (Supplementary Tables S3 and S4).
DOI: 10.6084/m9.figshare.28359056.v3
title: Real-time data stream

description: stream and sensor data
DOI: 10.6084/m9.figshare.21367914.v1
title: ZBTB20 Regulates Prolactin Expression and Lactotrope Function in Adult Mice

description: Supplemental Data
DOI: 10.6084/m9.figshare.21398841.v1
title: Data for Tiliroside suppresses Triple-negative breast cancer as a multifunctional CAXII inhibitor

description: Whole data including minimal datasets were used to support our finding. Data for studies of in vitro and in vivo has been uploaded. For instance, data for determining the change of intracellular pH (pHi), extracellular pH (pHe) and lactate level, for Caspase-3 activity, CAXII activity, etc, has all been included.
DOI: 10.6084/m9.figshare.4993667.v1
title: Sample size effects on the assessment of eukaryotic diversity and community structure in aquatic sediments using high-throughput sequencing

description: Data is 18S rRNA amplicons generated on an Illumina HiSeq (250-PE rapid run). <br>This is a methodological experiment where marine sediments have been subsampled using increasingly larger volumes of sediment from cores samples.<br>Data is from the following manuscript: <br>Nascimento, FJA, Lallias D, Bik, HM, Creer, S (submitted) Sample size effects on the assessment of eukaryotic diversity and community structure in aquatic sediments using high-throughput sequencing.
DOI: 10.6084/m9.figshare.24298183.v1
title: Attitudes towards Saudi English.csv

description: Saudi English as foreign language (EFL) learners’ attitudes towards an outer-circle English variety (Saudi English; henceforth, SE).
DOI: 10.6084/m9.figshare.24448237.v2
title: <b>Chromosome-level genome </b><b>assembly </b><b>of a </b><b>cliff plant </b><b><i>Taihangia </i></b><b><i>rupestris</i></b><b> var. </b><b><i>ciliata</i></b><b> provides insights into its demographic history and adaptation</b>

description: <b>Chromosome-level genome </b><b>assembly </b><b>of a </b><b>cliff plant </b><b><i>Taihangia </i></b><b><i>rupestris</i></b><b> var. </b><b><i>ciliata</i></b><b> provides insights into its demographic history and adaptation</b>
DOI: 10.17632/wt7b8sd6jw
title: Capital Market of Bangladesh and various Macroeconomic Variables

description: This dataset is the compilation of capital market variables, macroeconomic variables and various emission variables spanning from 1977 to 2022.
DOI: 10.17632/4t8j9dtjv4
title: Thermal tolerance of cyprinids data

description: All data from: Thermal tolerance of cyprinids along an urban-rural gradient: Plasticity, repeatability and effects of swimming and temperature shock
Jay A. Nelson *, Kelly J. Rieger, Danielle Gruber, Melinda Cutler, Bailee Buckner, Christopher E. Oufiero
Journal of Thermal Biology 100 (2021) 103047
DOI: 10.6084/m9.figshare.7560284.v1
title: Global patterns and impacts of El Niño events on coral reefs: A meta-analysis (Coral DHW Heat Stress Data)

description: This data set includes a quantification of coral heat stress. For any coral reef location in the world, this data set includes remotely-sensed degree heating weeks (DHW) for any date (1982-2016), quantification of the maximum DHW (during an individual El Niño event), and the time lag since the maximum DHW. This data set is described in detail in Claar et al. 2018 "Global patterns and impacts of El Niño events on coral reefs: A meta-analysis", https://doi.org/10.1371/journal.pone.0190957
DOI: 10.17632/8d3v8fkdy8
title: Official Tenure and Haze Pollution-- Empirical Test Based on Panel Data of 279 Cities in China

description: This is the data for paper：Official Tenure and Haze Pollution-- Empirical Test Based on Panel Data of 279 Cities in China. Abstract： Haze pollution is one of the urgent problems that need to be solved in the stage of high-quality development in China. As a kind of public goods, haze pollution is governed by local government, and the tenure of main leaders of local government determines the continuity of governance behavior. Existing literature often ignores the role of official tenure in the process of haze pollution governance. This paper selects the panel data of 279 prefecture cities in China and tests the relationship between official tenure and haze pollution empirically. This study found that : (1) Official tenure has a significant U-shaped impact on local haze pollution, and the turning point roughly occurred in 3.4 years. The influence of official's age on haze pollution rises first and then decreases with the increase of official tenure, while the influence of official's education level on haze pollution increases linearly with the increase of official tenure; (2) Fixed asset investment plays a significant mediation role in the process of official tenure affecting haze pollution; (3) Further analysis shows that there is a significant positive spatial correlation between inter-regional haze pollution, and the tenure of local official is more likely to have a significant inverted U-shaped impact on haze pollution in neighboring areas. Key words: Official Tenure; Official Characteristics; Haze Pollution; Promotion Incentive; Spatial Correlation HIGHLIGHTS The relationship between official tenure and haze pollution is explored. The role of official characteristics in the influence of official tenure on haze pollution was discussed. Fixed assets investment plays a mediating role in the relationship between official tenure and haze pollution. We further discussed the impact of official tenure on haze pollution from a spatial perspective.
DOI: 10.6084/m9.figshare.5126080.v1
title: Supplementary Material for: Immunoreactivity Distribution of Vasotocin and Vasoactive Intestinal Peptide in Brain Nuclei of Two Songbird Species with Different Breeding Systems

description: Vasopressin influences social behaviour in mammals, in particular social recognition and bonding. However, much less is known about its avian analogue, vasotocin, although vasotocin appears to modulate singing behaviour and agonistic interactions together with vasoactive intestinal peptide (VIP) in some songbirds. The objectives of our study were to compare the expression of vasotocin and VIP in brain nuclei hypothetised to be part of the social behavioural network, i.e. septal areas, bed nucleus of the stria terminalis and medial preoptic nucleus (POM), in two songbird species in the wild: the blue tit <i>(Cyanistes caeruleus)</i> and European penduline tit <i>(Remiz pendulinus)</i>. These two closely related passerine birds differ in their pair bonding and mating systems: blue tits are socially monogamous with extensive pair bond lasting for several months, whereas in the European penduline tit, pair bond is short and it dissolves during or after laying of the eggs. The two species did not differ in the distribution of vasotocin in the observed brain regions; however, VIP was more abundant in all three regions of penduline tits than in blue tits. We found a sex difference in favour of males in the distribution of vasotocin- and VIP-immunoreactive neurones, fibres and terminals in all three regions in penduline tits. In blue tits, such gender differences were only observed in the POM. The limited differences between the two species suggest that the levels of vasotocin and VIP in the socially relevant brain regions are likely influenced by many other social or environmental factors than just by differences in the duration of pair bonding.
DOI: 10.15468/dl.sja4yy
title: Occurrence Download

description: A dataset containing 91 species occurrences available in GBIF matching the query:
{
 "and" : [
 "HasGeospatialIssue is false",
 "HasCoordinate is true",
 "OccurrenceStatus is Present",
 {
 "not" : {
 "BasisOfRecord" : [
 "is one of (Observation, Human Observation, Machine Observation, Living Specimen)"
 ]
 }
 },
 "TaxonKey is Tipula helvola Loew, 1873"
 ]
}

 The dataset includes 91 records from 11 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0009431-250426092105405/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.17632/bsn4vh3zv7
title: Clustering results of evolutionary clustering algorithm star for clustering heterogeneous datasets

description: The data was collected from the written Java codes by the authors, and Weka packages for executing ECA* on 32 heterogenous and multi-featured datasets against its counterpart algorithms (KM, KM++, EM, LVQ, and GENCLUST++). Each of these algorithms was run thirty times on each of the 32 benchmarking dataset problems to evaluate the performance of ECA* against its competitve algorithms.
DOI: 10.6084/m9.figshare.25331725.v4
title: Análisis comparativo de las habilidades sociales en estudiantes de la carrera de psicología clínica.pdf

description: Se presenta un estudio psicométrico realizado a través de procedimientos confirmatorios de la Escala de habilidades sociales de Gismero (EHS), el cual tiene como finalidad la evaluación de la aserción y las habilidades sociales, donde se presentan las características generales del instrumento ocupado, revisando las propiedades psicométricas de medida del mismo. La muestra estuvo compuesta por 60 estudiantes universitarios de la Universidad Central del Ecuador de la facultad de Ciencias Psicológicas en la Licenciatura en Psicología Clínica. Se realizaron varios procedimientos como: prueba de Shapiro-Wilk, prueba de Levence, prueba de T-Student o Welch. Los cuales ayudaron a determinar cuál procedimiento era el más indicado para este estudio, y el resultado fue la prueba de T-Student. Ya que no existe una homogeneidad en las varianzas del estudio y sus tamaños muestrales no son iguales
DOI: 10.6084/m9.figshare.20780389.v1
title: Test datasets for the paper "Unsupervised anomaly detection in hourly water demand data using an asymmetric encoder-decoder model"

description: These are test datasets for the paper "Unsupervised anomaly detection in hourly water demand data using an asymmetric encoder-decoder model". The names of the datasets are self-explanatory and can be tracked in the paper (Figures 1, 8, 10, 11, and 14).
DOI: 10.6084/m9.figshare.28648883.v1
title: <b>Large-scale proteome mapping reveals heterogeneity in biological aging and its prediction of health outcomes across glycemic status</b>

description: Supplementary Tables
DOI: 10.6084/m9.figshare.12052995.v2
title: Integrative Network Fusion: a multi-omics approach in molecular profiling

description: Dataset used for "Integrative Network Fusion: a multi-omics approach in molecular profiling" article.
DOI: 10.6084/m9.figshare.20749096.v1
title: The Vinca minor genome highlights conserved evolutionary traits in monoterpene indole alkaloid synthesis

description: <em>Vinca minor</em> genome sequence (Vinca_minor_genome_v1.0.fasta), genome annotation file (vinca_minor_annotation.gff), transcript abundance estimates (vinca_minor.tpm) and a file containing a personalized script with dependency files (gene_cluster_analysis.tar.xz).
DOI: 10.6084/m9.figshare.28287227.v1
title: <i>Seasonal effects on growth, digestibility, and metabolism of preweaning dairy calves in the southeastern United States</i> Supplemental Data

description: The aim of the current study was to evaluate seasonal effects on growth, digestibility, and metabolism of dairy calves in Georgia. Holstein calves (n = 48 per season) were enrolled at 7 d of age (DOA) from June to Aug (defined as summer, BW = 40 ± 4 kg) and from Nov to Jan (defined as winter, BW = 42 ± 4 kg). Similar general management and feeding practices were applied to calves in both seasons. Calves were housed in individual polyethylene hutches with sand bedding. Starting at 2 DOA, calves were fed a milk replacer (MR) containing 26% protein and 17% fat (0.65 or 0.76 kg of DM/d and mixed with warm water to reach 12.5% solids) and calf starter (CS) was offered ad libitum. Weaning began at 43 DOA by reducing MR 50% until 49 DOA when MR feeding ceased. Calves remained enrolled until 63 DOA. Calf starter intake was recorded daily. Ambient temperature (AT) and relative humidity (RH) were recorded hourly. Rectal temperature and respiration rate were assessed 3×/wk and BW was measured weekly. Blood was collected to analyze metabolites and insulin at 3, 7, 14, 21, 28, 35, 42, 49, 56, and 63 DOA. The apparent total-tract digestibility of nutrients was measured during both the pre- (14.9–17.9 DOA) and postweaning (51.0–54.0 DOA) periods. The MIXED procedure of SAS was used to analyze repeated measures data. Season, time, and their interactions were included as the fixed effects. The CV of hourly AT or RH within a day was calculated as a proxy of within-day variation. The CV of daily average AT or RH within a week was used as the proxy of day-to-day variation. Linear regression analysis between ADG and environmental parameters was performed using the GLM procedure. Summer months had greater AT (27°C vs. 13°C) but similar RH (83% vs. 81%) relative to winter months, respectively. Rectal temperature and respiration rate were higher during the summer compared with winter. Season had no effect on CS intake before weaning, but summer calves had greater CS intake at 9 wk of age compared with winter calves. No seasonal effect was observed for BW, but summer calves had greater ADG at 3, 5, and 9 wk of age. A negative relationship (R2 = 0.11) between preweaning ADG and within-day AT variation was observed during winter, whereas during the summer day-to-day AT variation was negatively associated with preweaning ADG (R2 = 0.06). Compared with calves raised during winter, calves raised in summer had lower apparent total-tract digestibility of DM, OM, and CP during the preweaning period. Furthermore, summer calves had lower circulating glucose before and after weaning and lower blood BHB concentrations following weaning compared with calves raised in winter. In conclusion, in Georgia, the within-day and day-to-day AT variations affect preweaning calf growth, and calves raised during summer had lower nutrient digestibility and altered metabolism relative to calves raised in winter.
DOI: 10.6084/m9.figshare.28138535.v1
title: Zaorendao Au-Sb

description: <b>Extension veining-induced orogenic Au-Sb mineralization in the Zaorendao deposit, China</b>