cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.5720641.v1
title: Signs and symptoms in Gaucher Disease: priority nursing diagnoses

description: ABSTRACT Objective: Identify the signs and symptoms of patients with Gaucher Disease, inferring possible priority nursing diagnoses. Method: Cross-sectional study, developed in a specialized laboratory, between 2013 and 2015. The sample (n = 91) comprised the records of patients with genetic diagnosis for Gaucher Disease. The study respected research norms. Results: Prevalence of female sex (57.1%), age at diagnosis between 0 and 10 years, and origin from the Southeast Region of Brazil were prevalent. Hematologic changes, bone pain, hepatomegaly, splenomegaly, and fatigue were the most recurrent signs and symptoms. The inferred diagnoses for the studied population were: Risk for bleeding; Fatigue; Chronic pain and Acute pain; Impaired physical mobility; Imbalanced nutrition: less than body requirements; and Risk for Developmental Delay. Conclusion: The establishment of Priority Nursing Diagnoses based on signs and symptoms makes it possible to achieve expected outcomes for each individual in the care context.
DOI: 10.6084/m9.figshare.5720635
title: Undergraduate Course Duration in Medicine: an Estimation in the 15 Graduate Cohorts at the Agostinho Neto University, Angola

description: ABSTRACT The time required to complete undergraduate medical courses is well established in medical school training programs worldwide. However, not all students complete the degree in the expected timeframe, which can lead to a low graduation rate. Nevertheless, an isolated analysis of the graduation rate does not accurately predict the magnitude of training costs if it does not take into account the average completion time, particularly for undergraduate medical course for which the training time is longer and requires substantial resources. The aim of this study was to determine the length of time to complete the degree, as well as the proportion of students who graduated within the regular timeframe. In this retrospective study, we analysed data from 15 cohorts of medical students who finished the undergraduate program at the Faculty of Medicine of the Agostinho Neto University (FMUAN) in Angola, from 2001 to 2015. Data were collected from the academic records registered at the FMUAN. From the total number of graduates (n = 1259), 59.7% were women and the average age at course completion was 35 ± 7 years. The average admission rate was 6.8%, and it was found that 88 students (36 men and 52 women) had graduated per year. On average, students took 10 years to complete the degree. The graduation rate was 82.2%, and only 24.2% of the total graduates concluded the program in the regular period of six years. The results suggest that despite a high graduation rate, less than one third of the students finished the training program within the expected timeframe, highlighting the need to identify the causes of prolonged course duration which may have implications for both academic management and for human resource planning in health. Thus, a combined analysis of graduation rate and the time to complete the undergraduate course may be a good indicator of the efficiency of the medical education system.
DOI: 10.6084/m9.figshare.5720635.v1
title: Undergraduate Course Duration in Medicine: an Estimation in the 15 Graduate Cohorts at the Agostinho Neto University, Angola

description: ABSTRACT The time required to complete undergraduate medical courses is well established in medical school training programs worldwide. However, not all students complete the degree in the expected timeframe, which can lead to a low graduation rate. Nevertheless, an isolated analysis of the graduation rate does not accurately predict the magnitude of training costs if it does not take into account the average completion time, particularly for undergraduate medical course for which the training time is longer and requires substantial resources. The aim of this study was to determine the length of time to complete the degree, as well as the proportion of students who graduated within the regular timeframe. In this retrospective study, we analysed data from 15 cohorts of medical students who finished the undergraduate program at the Faculty of Medicine of the Agostinho Neto University (FMUAN) in Angola, from 2001 to 2015. Data were collected from the academic records registered at the FMUAN. From the total number of graduates (n = 1259), 59.7% were women and the average age at course completion was 35 ± 7 years. The average admission rate was 6.8%, and it was found that 88 students (36 men and 52 women) had graduated per year. On average, students took 10 years to complete the degree. The graduation rate was 82.2%, and only 24.2% of the total graduates concluded the program in the regular period of six years. The results suggest that despite a high graduation rate, less than one third of the students finished the training program within the expected timeframe, highlighting the need to identify the causes of prolonged course duration which may have implications for both academic management and for human resource planning in health. Thus, a combined analysis of graduation rate and the time to complete the undergraduate course may be a good indicator of the efficiency of the medical education system.
DOI: 10.6084/m9.figshare.5720632
title: Analysis of Dyssynchrony and Ventricular Function in Right Univentricular Stimulation at Different Positions

description: Abstract Introduction: Chronic stimulation of the right ventricle with pacemaker is associated with ventricular dyssynchrony and loss of contractility, even in subjects without previous dysfunction. In these patients, there is a debate of which pacing site is less associated with loss of ventricular function. Objective: To compare pacemaker-induced dyssynchrony among different pacing sites in right ventricular stimulation. Methods: Cross-sectional study of outpatients with right ventricle stimulation higher than 80% and preserved left ventricular ejection fraction. Pacing lead position (apical, medial septum or free wall) was assessed through chest X-rays. Every patient underwent echocardiogram to evaluate for dyssynchrony according to CARE-HF criteria: aortic pre-ejection time, interventricular delay and septum/posterior wall delay on M mode. Results: Forty patients were included. Fifty-two percent had apical electrode position, 42% mid septum and 6% free wall. Mean QRS time 148.97±15.52 milliseconds. A weak correlation between the mean QRS width and pre-aortic ejection time (r=0.32; P=0.04) was found. No difference in QRS width among the positions could be noted. Intraventricular delay was lower in apical patients against mid septal (34.4±17.2 vs. 54.3±19.1 P&lt;0.05) - no difference with those electrode on the free wall. No difference was noted in the pre-aortic ejection time (P=0.9). Conclusion: Apical pacing showed a lower interventricular conduction delay when compared to medial septum site. Our findings suggest that apical pacing dyssynchrony is not ubiquitous, as previously thought, and that it should remain an option for lead placement.
DOI: 10.6084/m9.figshare.5720632.v1
title: Analysis of Dyssynchrony and Ventricular Function in Right Univentricular Stimulation at Different Positions

description: Abstract Introduction: Chronic stimulation of the right ventricle with pacemaker is associated with ventricular dyssynchrony and loss of contractility, even in subjects without previous dysfunction. In these patients, there is a debate of which pacing site is less associated with loss of ventricular function. Objective: To compare pacemaker-induced dyssynchrony among different pacing sites in right ventricular stimulation. Methods: Cross-sectional study of outpatients with right ventricle stimulation higher than 80% and preserved left ventricular ejection fraction. Pacing lead position (apical, medial septum or free wall) was assessed through chest X-rays. Every patient underwent echocardiogram to evaluate for dyssynchrony according to CARE-HF criteria: aortic pre-ejection time, interventricular delay and septum/posterior wall delay on M mode. Results: Forty patients were included. Fifty-two percent had apical electrode position, 42% mid septum and 6% free wall. Mean QRS time 148.97±15.52 milliseconds. A weak correlation between the mean QRS width and pre-aortic ejection time (r=0.32; P=0.04) was found. No difference in QRS width among the positions could be noted. Intraventricular delay was lower in apical patients against mid septal (34.4±17.2 vs. 54.3±19.1 P&lt;0.05) - no difference with those electrode on the free wall. No difference was noted in the pre-aortic ejection time (P=0.9). Conclusion: Apical pacing showed a lower interventricular conduction delay when compared to medial septum site. Our findings suggest that apical pacing dyssynchrony is not ubiquitous, as previously thought, and that it should remain an option for lead placement.
DOI: 10.6084/m9.figshare.5720629
title: Socio-environmental vulnerability index: a methodological proposal based on the case of Rio de Janeiro, Brazil

description: Abstract The term vulnerability has been more frequently used in several studies, striving to better understand the specificities and needs of different population groups. The scope of this study was to identify, characterize and analyze populations in situations of socio-environmental vulnerability in Rio de Janeiro city, consolidating social, economic, environmental, health and public security indicators in a synthesis index – the Socio-Environmental Vulnerability Index. The data sources used were the IBGE-2010 Demographic Census, the Geo-Rio Foundation and the Public Security Institute of the state of Rio de Janeiro. The methodology integrated Multicriteria Decision Analysis into a Geographic Information System. According to our results, the socio-environmental vulnerability in Rio de Janeiro city is aggravated by risk situations and environmental degradation. Those aspects are accentuated by the population density in shantytown areas, where the most disadvantaged strata exist in a process of environmental and urban exclusion. The study makes it possible to locate spatially vulnerable areas, emphasizing the importance of these tools to guide resource allocation, formulation and implementation of more effective public policies.
DOI: 10.6084/m9.figshare.5720629.v1
title: Socio-environmental vulnerability index: a methodological proposal based on the case of Rio de Janeiro, Brazil

description: Abstract The term vulnerability has been more frequently used in several studies, striving to better understand the specificities and needs of different population groups. The scope of this study was to identify, characterize and analyze populations in situations of socio-environmental vulnerability in Rio de Janeiro city, consolidating social, economic, environmental, health and public security indicators in a synthesis index – the Socio-Environmental Vulnerability Index. The data sources used were the IBGE-2010 Demographic Census, the Geo-Rio Foundation and the Public Security Institute of the state of Rio de Janeiro. The methodology integrated Multicriteria Decision Analysis into a Geographic Information System. According to our results, the socio-environmental vulnerability in Rio de Janeiro city is aggravated by risk situations and environmental degradation. Those aspects are accentuated by the population density in shantytown areas, where the most disadvantaged strata exist in a process of environmental and urban exclusion. The study makes it possible to locate spatially vulnerable areas, emphasizing the importance of these tools to guide resource allocation, formulation and implementation of more effective public policies.
DOI: 10.6084/m9.figshare.5720626
title: Solidifying agents and activated charcoal for in vitro culture of Solanum sessiliflorum

description: Abstract: The objective of this work was to evaluate the effects of the solidifying agents agar and phytagel and of activated charcoal on the in vitro cultivation of two maná cubiu (Solanum sessiliflorum) varieties: Thaís and Santa Luzia. The phytotechnical characteristics analyzed included number of leaves, number of roots, shoot and root length, and fresh matter of shoot and root. Regardless of the variety, phytagel was superior to agar as a culture medium. A greater number of leaves and longer shoots were observed in the Santa Luzia variety, in the absence of charcoal. The Thaís variety showed longer shoots and roots in the presence of charcoal.
DOI: 10.6084/m9.figshare.5720626.v1
title: Solidifying agents and activated charcoal for in vitro culture of Solanum sessiliflorum

description: Abstract: The objective of this work was to evaluate the effects of the solidifying agents agar and phytagel and of activated charcoal on the in vitro cultivation of two maná cubiu (Solanum sessiliflorum) varieties: Thaís and Santa Luzia. The phytotechnical characteristics analyzed included number of leaves, number of roots, shoot and root length, and fresh matter of shoot and root. Regardless of the variety, phytagel was superior to agar as a culture medium. A greater number of leaves and longer shoots were observed in the Santa Luzia variety, in the absence of charcoal. The Thaís variety showed longer shoots and roots in the presence of charcoal.
DOI: 10.6084/m9.figshare.5720623
title: Subcutaneous Implantable Cardioverter Defibrillator: Early Experience

description: Abstract Introduction: The implantable cardioverter defibrillator had been increasing the survival of patients at high risk for sudden cardiac death. The subcutaneous implantable cardioverter defibrillator was developed to mitigate the complications inherent to lead placement into cardiovascular system. Objective: To report the initial experience of 18 consecutive cases of subcutaneous implantable cardioverter defibrillator implantation showing the indications, potential pitfalls and perioperative complications. Methods: Between September 2016 and March 2017, 18 patients with indication for primary and secondary prevention of sudden cardiac death, with no concomitant indication for artificial cardiac pacing, were included. Results: The implantation of the subcutaneous implantable cardioverter defibrillator successfully performed in 18 patients. It was difficult to place the subcutaneous lead at the parasternal line in two patients. One patient returned a week after the procedure complaining about an increase in pain intensity at pulse generator pocket site, which was associated with edema, temperature rising and hyperemia. Two patients took antialgic medication for five days after surgery. A reintervention was necessary in one patient to replace the lead in order to correct inappropriate shocks caused by myopotential oversensing. Conclusion: In our initial experience, although the subcutaneous implantable cardioverter defibrillator implantation is a less-invasive, simple-accomplishment procedure, it resulted in a bloodier surgery perhaps requiring an operative care different from the conventional. Inappropriate shock by oversensing is a reality in this system, which should be overcame in order not to become a limiting issue for its indication.
DOI: 10.6084/m9.figshare.5720623.v1
title: Subcutaneous Implantable Cardioverter Defibrillator: Early Experience

description: Abstract Introduction: The implantable cardioverter defibrillator had been increasing the survival of patients at high risk for sudden cardiac death. The subcutaneous implantable cardioverter defibrillator was developed to mitigate the complications inherent to lead placement into cardiovascular system. Objective: To report the initial experience of 18 consecutive cases of subcutaneous implantable cardioverter defibrillator implantation showing the indications, potential pitfalls and perioperative complications. Methods: Between September 2016 and March 2017, 18 patients with indication for primary and secondary prevention of sudden cardiac death, with no concomitant indication for artificial cardiac pacing, were included. Results: The implantation of the subcutaneous implantable cardioverter defibrillator successfully performed in 18 patients. It was difficult to place the subcutaneous lead at the parasternal line in two patients. One patient returned a week after the procedure complaining about an increase in pain intensity at pulse generator pocket site, which was associated with edema, temperature rising and hyperemia. Two patients took antialgic medication for five days after surgery. A reintervention was necessary in one patient to replace the lead in order to correct inappropriate shocks caused by myopotential oversensing. Conclusion: In our initial experience, although the subcutaneous implantable cardioverter defibrillator implantation is a less-invasive, simple-accomplishment procedure, it resulted in a bloodier surgery perhaps requiring an operative care different from the conventional. Inappropriate shock by oversensing is a reality in this system, which should be overcame in order not to become a limiting issue for its indication.
DOI: 10.6084/m9.figshare.5720620
title: Tarsal platform show after upper eyelid blepharoplasty with or without brassiere sutures

description: ABSTRACT Purpose: Increased tarsal platform show (TPS) and decreased brow fat span (BFS) are associated with favorable results in women undergoing cosmetic blepharoplasty. We conducted a study to evaluate the efficacy of upper blepharoplasty with or without a technique (brassiere sutures) to increase TPS and decrease BFS. Methods: This is a prospective, randomized, comparative, case series study of 100 eyelids (50 consecutive women patients) treated with cosmetic upper blepharoplasty performed by a single surgeon. Patients were randomized to receive traditional upper blepharoplasty with a single running suture skin closure versus orbicularis oculi muscle fixation to the periosteum (brassiere sutures) prior to skin closure. Data on patient age, duration of follow-up, complications, and treatment were analyzed. The mean TPS, mean BFS, and mean TPS/BFS ratio were measured at three anatomic landmarks before and after surgery. Results: Fifty-six eyelids (28 patients) were treated with traditional single suture blepharoplasty, and 44 eyelids (22 patients) had brassiere sutures. In both groups, paired t-tests indicate significant differences between preoperative and postoperative evaluations (p&lt;0.05) for eyelid parameters in each location. However, when TPS, BFS, and TPS/BFS ratio were compared between groups with two-way ANOVA, there were no statistically significant differences (p&gt;0.05). Conclusions: Brassiere sutures during upper blepharoplasty and traditional blepharoplasty were associated with postoperative increase in TPS, decrease in BFS, and increase in TPS/BFS, without statistically significant differences between these surgeries.
DOI: 10.6084/m9.figshare.5720620.v1
title: Tarsal platform show after upper eyelid blepharoplasty with or without brassiere sutures

description: ABSTRACT Purpose: Increased tarsal platform show (TPS) and decreased brow fat span (BFS) are associated with favorable results in women undergoing cosmetic blepharoplasty. We conducted a study to evaluate the efficacy of upper blepharoplasty with or without a technique (brassiere sutures) to increase TPS and decrease BFS. Methods: This is a prospective, randomized, comparative, case series study of 100 eyelids (50 consecutive women patients) treated with cosmetic upper blepharoplasty performed by a single surgeon. Patients were randomized to receive traditional upper blepharoplasty with a single running suture skin closure versus orbicularis oculi muscle fixation to the periosteum (brassiere sutures) prior to skin closure. Data on patient age, duration of follow-up, complications, and treatment were analyzed. The mean TPS, mean BFS, and mean TPS/BFS ratio were measured at three anatomic landmarks before and after surgery. Results: Fifty-six eyelids (28 patients) were treated with traditional single suture blepharoplasty, and 44 eyelids (22 patients) had brassiere sutures. In both groups, paired t-tests indicate significant differences between preoperative and postoperative evaluations (p&lt;0.05) for eyelid parameters in each location. However, when TPS, BFS, and TPS/BFS ratio were compared between groups with two-way ANOVA, there were no statistically significant differences (p&gt;0.05). Conclusions: Brassiere sutures during upper blepharoplasty and traditional blepharoplasty were associated with postoperative increase in TPS, decrease in BFS, and increase in TPS/BFS, without statistically significant differences between these surgeries.
DOI: 10.6084/m9.figshare.5720617
title: DNA barcoding reveals the diversity of sharks in Guyana coastal markets

description: ABSTRACT A fundamental challenge for both sustainable fisheries and biodiversity protection in the Neotropics is the accurate determination of species identity. The biodiversity of the coastal sharks of Guyana is poorly understood, but these species are subject to both artisanal fishing as well as harvesting by industrialized offshore fleets. To determine what species of sharks are frequently caught and consumed along the coastline of Guyana, we used DNA barcoding to identify market specimens. We sequenced the mitochondrial co1 gene for 132 samples collected from six markets, and compared our sequences to those available in the Barcode of Life Database (BOLD) and GenBank. Nearly 30% of the total sample diversity was represented by two species of Hammerhead Sharks (Sphyrna mokarran and S. lewini), both listed as Endangered by the International Union for Conservation of Nature (IUCN). Other significant portions of the samples included Sharpnose Sharks (23% - Rhizoprionodon spp.), considered Vulnerable in Brazilian waters due to unregulated gillnet fisheries, and the Smalltail Shark (17% - Carcharhinus porosus). We found that barcoding provides efficient and accurate identification of market specimens in Guyana, making this study the first in over thirty years to address Guyana’s coastal shark biodiversity.
DOI: 10.6084/m9.figshare.5720617.v1
title: DNA barcoding reveals the diversity of sharks in Guyana coastal markets

description: ABSTRACT A fundamental challenge for both sustainable fisheries and biodiversity protection in the Neotropics is the accurate determination of species identity. The biodiversity of the coastal sharks of Guyana is poorly understood, but these species are subject to both artisanal fishing as well as harvesting by industrialized offshore fleets. To determine what species of sharks are frequently caught and consumed along the coastline of Guyana, we used DNA barcoding to identify market specimens. We sequenced the mitochondrial co1 gene for 132 samples collected from six markets, and compared our sequences to those available in the Barcode of Life Database (BOLD) and GenBank. Nearly 30% of the total sample diversity was represented by two species of Hammerhead Sharks (Sphyrna mokarran and S. lewini), both listed as Endangered by the International Union for Conservation of Nature (IUCN). Other significant portions of the samples included Sharpnose Sharks (23% - Rhizoprionodon spp.), considered Vulnerable in Brazilian waters due to unregulated gillnet fisheries, and the Smalltail Shark (17% - Carcharhinus porosus). We found that barcoding provides efficient and accurate identification of market specimens in Guyana, making this study the first in over thirty years to address Guyana’s coastal shark biodiversity.