cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.11609643
title: Communicating Bad News: an Essential Tool in Undergraduate Medical School

description: ABSTRACT Communication is a dynamic and open process and, in the field of health, it involves from the transmission of messages to obtaining information. “Bad news” can be considered all information that involves a drastic and negative change in the patient’s life and regarding the perspective of the future. To give “bad news” to the patient includes everything from a diagnosis of a terminal illness, to pathologies that interfere with their quality of life. In Brazil, there is a problem regarding this subject, because there is not much content in the curricular grid about the communication of bad news, as well as little practice on the use of communication methods. This directly impacts both the professional and personal life of the future physician, as well as the relationship with the patient. The present article is a cross-sectional descriptive study, carried out in the cities of Joinville and Jaraguá do Sul, and the project was submitted to and approved by the institutions’ ethical assessment according to Brazilian standards. It aims to describe the understanding of sixth-year undergraduate medical students and first-year residents when dealing with the reporting of bad news. The sample consisted of 63 participants, with data collected from a questionnaire, between April and September 2018 and analyzed descriptively in terms of frequency of each response. As for the results, it is noteworthy that the task considered the most difficult one was to talk about the end of an attempted curative treatment; 61% considered themselves reasonably skilled regarding the ability to communicate bad news, and that involving the family member or patient in the decision-making process is the most difficult factor during the discussion. In addition, 74% of the participants were unaware of any method of communication and 44% believed that practical classes with real patients would be an effective way of learning. Therefore, it is concluded that the lack of preparation to mediate such situations implies in heterogeneous behaviors that could be avoided with instructions and would contribute to the best training during undergraduate medical school.
DOI: 10.6084/m9.figshare.11609646
title: Effect of norbixin-based poly(hydroxybutyrate) membranes on the tendon repair process after tenotomy in rats

description: Abstract Purpose: To determine the efficacy of norbixin-based poly(hydroxybutyrate) (PHB) membranes for Achilles tendon repair. Methods: Thirty rats were submitted to total tenotomy surgery of the right Achilles tendon and divided into two groups (control and membrane; n = 15 each), which were further subdivided into three subgroups (days 7, 14, and 21; n = 5 each). Samples were analyzed histologically. Results: Histological analysis showed a significant reduction in inflammatory infiltrates on days 7, 14 (p &lt; 0.0001 for both), and 21 (p = 0.0004) in the membrane group compared to that in the control group. There was also a significant decrease in the number of fibroblasts in the control group on days 7, 14 (p &lt; 0.0001), and 21 (p = 0.0032). Further, an increase in type I collagen deposition was observed in the membrane group compared to that in the control group on days 7 (p = 0.0133) and 14 (p = 0.0107). Conclusion: Treatment with norbixin-based PHB membranes reduces the inflammatory response, increases fibroblast proliferation, and improves collagen production in the tendon repair region, especially between days 7 and 14.
DOI: 10.6084/m9.figshare.11609643.v1
title: Communicating Bad News: an Essential Tool in Undergraduate Medical School

description: ABSTRACT Communication is a dynamic and open process and, in the field of health, it involves from the transmission of messages to obtaining information. “Bad news” can be considered all information that involves a drastic and negative change in the patient’s life and regarding the perspective of the future. To give “bad news” to the patient includes everything from a diagnosis of a terminal illness, to pathologies that interfere with their quality of life. In Brazil, there is a problem regarding this subject, because there is not much content in the curricular grid about the communication of bad news, as well as little practice on the use of communication methods. This directly impacts both the professional and personal life of the future physician, as well as the relationship with the patient. The present article is a cross-sectional descriptive study, carried out in the cities of Joinville and Jaraguá do Sul, and the project was submitted to and approved by the institutions’ ethical assessment according to Brazilian standards. It aims to describe the understanding of sixth-year undergraduate medical students and first-year residents when dealing with the reporting of bad news. The sample consisted of 63 participants, with data collected from a questionnaire, between April and September 2018 and analyzed descriptively in terms of frequency of each response. As for the results, it is noteworthy that the task considered the most difficult one was to talk about the end of an attempted curative treatment; 61% considered themselves reasonably skilled regarding the ability to communicate bad news, and that involving the family member or patient in the decision-making process is the most difficult factor during the discussion. In addition, 74% of the participants were unaware of any method of communication and 44% believed that practical classes with real patients would be an effective way of learning. Therefore, it is concluded that the lack of preparation to mediate such situations implies in heterogeneous behaviors that could be avoided with instructions and would contribute to the best training during undergraduate medical school.
DOI: 10.6084/m9.figshare.11609646.v1
title: Effect of norbixin-based poly(hydroxybutyrate) membranes on the tendon repair process after tenotomy in rats

description: Abstract Purpose: To determine the efficacy of norbixin-based poly(hydroxybutyrate) (PHB) membranes for Achilles tendon repair. Methods: Thirty rats were submitted to total tenotomy surgery of the right Achilles tendon and divided into two groups (control and membrane; n = 15 each), which were further subdivided into three subgroups (days 7, 14, and 21; n = 5 each). Samples were analyzed histologically. Results: Histological analysis showed a significant reduction in inflammatory infiltrates on days 7, 14 (p &lt; 0.0001 for both), and 21 (p = 0.0004) in the membrane group compared to that in the control group. There was also a significant decrease in the number of fibroblasts in the control group on days 7, 14 (p &lt; 0.0001), and 21 (p = 0.0032). Further, an increase in type I collagen deposition was observed in the membrane group compared to that in the control group on days 7 (p = 0.0133) and 14 (p = 0.0107). Conclusion: Treatment with norbixin-based PHB membranes reduces the inflammatory response, increases fibroblast proliferation, and improves collagen production in the tendon repair region, especially between days 7 and 14.
DOI: 10.6084/m9.figshare.11609637
title: A NEW COMPUTATIONAL FLUID DYNAMICS STUDY OF A LIQUID-LIQUID HYDROCYCLONE IN THE TWO PHASE CASE FOR SEPARATION OF OIL DROPLETS AND WATER

description: Abstract A liquid-liquid hydrocyclone, so-called de-oiling equipment, was investigated for separation of oil droplets and wastewater in an Iranian petroleum unit. To generate the geometry and the mesh of the hydrocyclone Gambit software was used. Afterwards, by taking advantage of the Euler-Lagrangian principle, the governing equations covering the motion of fluid and that of particles in the hydrocyclone were solved. Initially, it was shown that the outcomes of CFD are in agreement with experimental data, and then 15 hydrocyclones with different overflow diameters, overflow lengths and input velocities were employed for more detailed analyses. The separation process through a hydrocyclone is counted as an economical process when ther is not only a low pressure drop inside the hydrocyclone, but also a high separation efficiency. As a result, regarding the mentioned criteria, the optimum hydrocyclone, whereby the highest performance of the hydrocyclone is exploited, was obtained by applying the 15 sets of CFD data to a Neural Network (NN) and then by optimizing the function generated by the NN by means of a Genetic Algorithm (GA). The innovation of this research work is the three-phase modeling.
DOI: 10.6084/m9.figshare.11609634
title: Idiopathic thrombocytopenic purpura in a patient with situs inversus totalis: case report and literature review

description: ABSTRACT Situs inversus totalis is a rare recessive autosomal congenital abnormality in which the mediastinal and abdominal organs are in a mirrored position when compared to the usual topography. The literature reports some cases of situs inversus totalis and concomitant conditions: spinal abnormalities, cardiac malformations and hematological diseases, such as idiopathic thrombocytopenic purpura, which is an autoimmune disease that causes thrombocytopenia due to platelet destruction or suppression of its production. This article aimed to report the coexistence of situs inversus totalis and idiopathic thrombocytopenic purpura.
DOI: 10.6084/m9.figshare.11609637.v1
title: A NEW COMPUTATIONAL FLUID DYNAMICS STUDY OF A LIQUID-LIQUID HYDROCYCLONE IN THE TWO PHASE CASE FOR SEPARATION OF OIL DROPLETS AND WATER

description: Abstract A liquid-liquid hydrocyclone, so-called de-oiling equipment, was investigated for separation of oil droplets and wastewater in an Iranian petroleum unit. To generate the geometry and the mesh of the hydrocyclone Gambit software was used. Afterwards, by taking advantage of the Euler-Lagrangian principle, the governing equations covering the motion of fluid and that of particles in the hydrocyclone were solved. Initially, it was shown that the outcomes of CFD are in agreement with experimental data, and then 15 hydrocyclones with different overflow diameters, overflow lengths and input velocities were employed for more detailed analyses. The separation process through a hydrocyclone is counted as an economical process when ther is not only a low pressure drop inside the hydrocyclone, but also a high separation efficiency. As a result, regarding the mentioned criteria, the optimum hydrocyclone, whereby the highest performance of the hydrocyclone is exploited, was obtained by applying the 15 sets of CFD data to a Neural Network (NN) and then by optimizing the function generated by the NN by means of a Genetic Algorithm (GA). The innovation of this research work is the three-phase modeling.
DOI: 10.6084/m9.figshare.11609631
title: Competency Profile in Genetics for Physicians in Brazil: A Proposal of the Brazilian Society of Medical Genetics and Genomics

description: ABSTRACT Training in genetics is fundamental to understanding the biological aspects of the health-disease binomial. Moreover, with the change in the epidemiological profile, genetically determined disorders have become more relevant as a public health concern. Thus, managing these disorders in an ethical and diligent manner, both in patients and in their families, and considering the logic and policies of the Brazilian Unified Health System (SUS), has become a desirable competency for all physicians, impacting on their undergraduate training. Viewing this issue as relevant, the Brazilian Society of Medical Genetics and Genomics (SBGM) defined the desirable competencies in genetics for Brazilian physicians, tied to the public policies related to medical genetics in Brazil. This paper is a theoretical essay that aims to contextualize and present the competency profile in Genetics for physicians proposed by the SBGM. The proficiency profile, presented and discussed in this essay, was structured based on four essential competencies: (1) to recognise the necessity for continuing education, regularly examining one’s own clinical competency, identifying learning gaps and the advances of genetics and of genomics over time; (2) to identify individuals that present or can develop a genetic disorder and know how and when to refer the patient to a specialist in medical genetics; (3) to manage patients with previously diagnosed genetic disorders and/or birth defects, employing established clinical guidelines in the scope of their professional role; and (4) to promote and stimulate clinical and education practices aimed at preventing genetic disorders and birth defects. The knowledge, skills and attitudes required for attaining these four competencies were identified. Therefore, a competency-based theoretical reference is presented to support the teaching of genetics during medical training. It is proposed that this essential competency profile in genetics should be adopted in all Brazilian medical schools with the purpose of training physicians better prepared for the current demands of the SUS. Furthermore, this competency profile can support continuing professional education actions in the area of Genetics, in order to qualify SUS staff in relation to genetic disorders and birth defects.
DOI: 10.6084/m9.figshare.11609634.v1
title: Idiopathic thrombocytopenic purpura in a patient with situs inversus totalis: case report and literature review

description: ABSTRACT Situs inversus totalis is a rare recessive autosomal congenital abnormality in which the mediastinal and abdominal organs are in a mirrored position when compared to the usual topography. The literature reports some cases of situs inversus totalis and concomitant conditions: spinal abnormalities, cardiac malformations and hematological diseases, such as idiopathic thrombocytopenic purpura, which is an autoimmune disease that causes thrombocytopenia due to platelet destruction or suppression of its production. This article aimed to report the coexistence of situs inversus totalis and idiopathic thrombocytopenic purpura.
DOI: 10.6084/m9.figshare.11609631.v1
title: Competency Profile in Genetics for Physicians in Brazil: A Proposal of the Brazilian Society of Medical Genetics and Genomics

description: ABSTRACT Training in genetics is fundamental to understanding the biological aspects of the health-disease binomial. Moreover, with the change in the epidemiological profile, genetically determined disorders have become more relevant as a public health concern. Thus, managing these disorders in an ethical and diligent manner, both in patients and in their families, and considering the logic and policies of the Brazilian Unified Health System (SUS), has become a desirable competency for all physicians, impacting on their undergraduate training. Viewing this issue as relevant, the Brazilian Society of Medical Genetics and Genomics (SBGM) defined the desirable competencies in genetics for Brazilian physicians, tied to the public policies related to medical genetics in Brazil. This paper is a theoretical essay that aims to contextualize and present the competency profile in Genetics for physicians proposed by the SBGM. The proficiency profile, presented and discussed in this essay, was structured based on four essential competencies: (1) to recognise the necessity for continuing education, regularly examining one’s own clinical competency, identifying learning gaps and the advances of genetics and of genomics over time; (2) to identify individuals that present or can develop a genetic disorder and know how and when to refer the patient to a specialist in medical genetics; (3) to manage patients with previously diagnosed genetic disorders and/or birth defects, employing established clinical guidelines in the scope of their professional role; and (4) to promote and stimulate clinical and education practices aimed at preventing genetic disorders and birth defects. The knowledge, skills and attitudes required for attaining these four competencies were identified. Therefore, a competency-based theoretical reference is presented to support the teaching of genetics during medical training. It is proposed that this essential competency profile in genetics should be adopted in all Brazilian medical schools with the purpose of training physicians better prepared for the current demands of the SUS. Furthermore, this competency profile can support continuing professional education actions in the area of Genetics, in order to qualify SUS staff in relation to genetic disorders and birth defects.
DOI: 10.6084/m9.figshare.11609625
title: Epidemiological Profile and Quality of Life of Medicine Students with Primary Hyperhidrosis

description: ABSTRACT Hyperhidrosis is the excessive production of sweat by the body, which can be primary or secondary and generalized or localized. The craniofacial, axillary, palmar, dorsum, inner thigh, and plantar regions are commonly affected. Primary hyperhidrosis (HP), although a benign disease, has an imminent negative impact on the patient’s quality of life. This disease is quantitatively classified according to the Hyperhidrosis Disease Severity Scale, based on how the disease affects daily activities, ranging from mild to severe intensity. Medical undergraduate students face physical and emotional stressful situations during their tasks, and when they have a chronic illness such as HP, they can be stigmatized as unsafe for their profession. The objective was to define HP prevalence, diagnostic criteria, severity and impact on the quality of life in the professional and extracurricular scenario of undergraduate medical students. This is a cross-sectional quantitative study of a descriptive nature, including 300 students from the Tiradentes University medical school, in Aracaju-SE, from August to November 2017. Absolute and relative frequencies were used in the case of categorical variables and measures of central tendency and variability were used for numerical variables; p value was considered significant when p &lt;0.05. The prevalence of HP in medical students was 18%, with no difference between the genders and with the predominance of white and brown ethnicities. The disease occurred mainly in combined sites, such as palmar-plantar, with the palmar region being the most affected one. The symptoms began mainly during childhood and adolescence, with significant impairment in daily personal and work activities, with disease exacerbation under stress situations. The most common HP severity was moderate, with a negative impact on quality of life, mainly reported at the more advanced stages of the disease, hindering academic activities. It is important to include the knowledge of HP in the medical curriculum for a greater dissemination of information on the disease, allowing its early diagnosis and related to the intensity of sweating in its therapeutic approach.
DOI: 10.6084/m9.figshare.11609628
title: TiO2 Decorated Sand Grains for Photodegradation of Pollutants: Methylene Blue and Ciprofloxacin Study

description: This study shows a preparation and evaluation of a new non-expensive TiO2 based photocatalyst built over sand grains surfaces as an alternative green technology for water treatment. The semiconductor covalently bonded to the silica sand grains (sand@TiO2) prepared by hydrolysis of isopropoxide orthotitane over sand grains, showed a high surface area 296 m2 g-1 and a high reaction rate for methylene blue (MB) photodegradation (0.064 min-1), on steady state condition by using 3 g of sand@TiO2 and an MB solution (20 mL, 3 × 10-5 mol L-1) or ciprofloxacin hydrochloride (CIP) solution (20 mL, 1.9 × 10-3 mol L-1). Under UV irradiation with a medium pressure Hg lamp, the total MB removal reached 70% after 7 min and 45% for CIP in 60 min. Further, the photocatalyst showed to be a promising reusable material for removal of ciprofloxacin hydrochloride antibiotic (CIP) on wastewater. This new material appears as a new promising low cost and low impact reusable catalyst for water treatment.
DOI: 10.6084/m9.figshare.11609625.v1
title: Epidemiological Profile and Quality of Life of Medicine Students with Primary Hyperhidrosis

description: ABSTRACT Hyperhidrosis is the excessive production of sweat by the body, which can be primary or secondary and generalized or localized. The craniofacial, axillary, palmar, dorsum, inner thigh, and plantar regions are commonly affected. Primary hyperhidrosis (HP), although a benign disease, has an imminent negative impact on the patient’s quality of life. This disease is quantitatively classified according to the Hyperhidrosis Disease Severity Scale, based on how the disease affects daily activities, ranging from mild to severe intensity. Medical undergraduate students face physical and emotional stressful situations during their tasks, and when they have a chronic illness such as HP, they can be stigmatized as unsafe for their profession. The objective was to define HP prevalence, diagnostic criteria, severity and impact on the quality of life in the professional and extracurricular scenario of undergraduate medical students. This is a cross-sectional quantitative study of a descriptive nature, including 300 students from the Tiradentes University medical school, in Aracaju-SE, from August to November 2017. Absolute and relative frequencies were used in the case of categorical variables and measures of central tendency and variability were used for numerical variables; p value was considered significant when p &lt;0.05. The prevalence of HP in medical students was 18%, with no difference between the genders and with the predominance of white and brown ethnicities. The disease occurred mainly in combined sites, such as palmar-plantar, with the palmar region being the most affected one. The symptoms began mainly during childhood and adolescence, with significant impairment in daily personal and work activities, with disease exacerbation under stress situations. The most common HP severity was moderate, with a negative impact on quality of life, mainly reported at the more advanced stages of the disease, hindering academic activities. It is important to include the knowledge of HP in the medical curriculum for a greater dissemination of information on the disease, allowing its early diagnosis and related to the intensity of sweating in its therapeutic approach.
DOI: 10.6084/m9.figshare.19545061.v3
title: data.zip

description: data
DOI: 10.34740/kaggle/dsv/3427640
title: Russian Invasion of Ukraine
DOI: 10.6084/m9.figshare.19545061.v4
title: data.zip

description: data
DOI: 10.6084/m9.figshare.11808789
title: Transcriptomics on slc39a14 mutants treated with MnCl2

description: Processed counts for the DeTCT data presented in Tuschl et al. 2020 (doi: https://doi.org/10.1101/2020.01.31.921130)<br>slc39a14-mn-grcz11-samples.txt contains the sample information (SampleID, Genotype, Treatment etc)<br><br>slc39a14-mn-grcz11.tsv contains the count information for the measured regions with associated gene information.<br><br>
DOI: 10.5281/zenodo.6417492
title: Messenger magentometer and coordinates dataset for Machine learning

description: This dataset is based on the original MESSENGER mission magnetometer and coordinate data as made available at PDS PPI. It introduces a number of improvements upon the original [1 sec temporal resolution]: Magnetometer calibration signals have been removed. Coordinates and magnetic field measurements have been merged together. Additional fields, such as model dipole magnetic field and planetary position in a heliocentric coordinate system have been added. The dataset has been split up into files by orbit numbers, with each file centered on the periapsis. Data for a number of partially recorded orbits has been removed.