cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.5980384.v1
title: Thoraco-laparoscopic esophagectomy: thoracic stage in prone position

description: ABSTRACT Objective: to analyze the National Cancer Institute Abdominopelvic Division (INCA / MS/HC I) initial experience with thoraco-laparoscopic esophagectomy with thoracic stage in prone position. Methods: we studied 19 consecutive thoraco-laparoscopic esophagectomies from may 2012 to august 2014, including ten patients with squamous cells carcinoma (five of the middle third and five of the lower third) and nine cases of gastroesophageal junction adenocarcinoma (six Siewert I and three Siewert II). All procedures were initiated by the prone thoracic stage. Results: There were minimal blood loss, optimal mediastinal visualization, oncological radicality and no conversions. Surgical morbidity was 42 %, most being minor complications (58% Clavien I or II), with few related to the technique. The most common complication was cervical anastomotic leak (37%), with a low anastomotic stricture rate (two stenosis: 10.53%). We had one (5.3%) surgical related death, due to a gastric tube`s mediastinal leak, treated by open reoperation and neck diversion. The median Intensive Care Unit stay and hospital stay were two and 12 days, respectively. The mean thoracoscopic stage duration was 77 min. Thirteen patients received neoadjuvant treatment (five squamous cells carcinoma and eight gastroesophageal adenocarcinomas). The average lymph node sample had 16.4 lymph nodes per patient and 22.67 when separately analyzing patients without neoadjuvant treatment. Conclusion: the thoraco-laparoscopic approach was a safe technique in the surgical treatment of esophageal cancer, with a good lymph node sampling.
DOI: 10.6084/m9.figshare.5980390.v1
title: Use of transfer factor in immunosuppressed surgical patients

description: ABSTRACT Objective : to evaluate the action of Transfer Factor on the immune response of patients with malignant neoplasm submitted to surgery, chemotherapy and radiotherapy. Method: we analyzed the variations of leukocytes, total lymphocytes, T-lymphocytes and CD4 counts in 60 patients submitted to immunostimulation with a single, daily dose of 0.5mg sublingual Transfer Factor, started simultaneously with chemotherapy and/or radiotherapy. Results: there were statistically significant increases in the counts of all cell lines studied, more pronounced after 12 months of use of the medication. Conclusion: the Transfer Factor restored immune response and showed no side effects.
DOI: 10.6084/m9.figshare.5980390
title: Use of transfer factor in immunosuppressed surgical patients

description: ABSTRACT Objective : to evaluate the action of Transfer Factor on the immune response of patients with malignant neoplasm submitted to surgery, chemotherapy and radiotherapy. Method: we analyzed the variations of leukocytes, total lymphocytes, T-lymphocytes and CD4 counts in 60 patients submitted to immunostimulation with a single, daily dose of 0.5mg sublingual Transfer Factor, started simultaneously with chemotherapy and/or radiotherapy. Results: there were statistically significant increases in the counts of all cell lines studied, more pronounced after 12 months of use of the medication. Conclusion: the Transfer Factor restored immune response and showed no side effects.
DOI: 10.6084/m9.figshare.5980396.v1
title: Effects of dimethylsulfoxide and pentoxifylline in the vitality of cutaneous flaps in rats

description: ABSTRACT Objectives: to verify the influence of dimethylsulfoxide and pentoxifylline on the vitality of cutaneous flaps in rats and the tissue repair process. Methods: were studied 30 Wistar rats, submitting them to a 2cm wide by 8cm long dorsal cutaneous flap, of caudal base. We distributed the animals in three groups: Control Group (n=10) with application gauze moistened with 0.9% Saline in the flap bed for 30 seconds; Dimethylsulfoxide group (n=10), with administration of 1ml of 5% dimethylsulfoxide divided into five injections of 0.2ml in the transition of the flap segments; Pentoxifylline group (n=10), with administration of pentoxifylline 20mg/kg, diluted to 1ml and divided into five injections of 0.2ml in the transition of the flap segments. Drugs were administered intraoperatively, in a single dose and subcutaneously. We observed the skin flaps for changes in color and texture. On the 10th postoperative day, we checked the dimensions of viable and necrotic tissues, followed by excision of the specimen for histological analysis. Results: the measurements of length of the viable and necrotic tissues between groups showed no differences. Histological analysis showed that the Dimethylsulfoxide group presented neovascularization, inflammatory infiltrate with leukocytes and more structured conjunctival stroma. The Pentoxifylline group showed neovascularization and inflammatory infiltrate, with moderate to intense granulation. The control group evolved with a higher rate of necrosis in the distal segment. Conclusion: dimethylsulfoxide and pentoxifylline influenced the vitality of the flap and the tissue repair process. However, they did not prevent necrosis macroscopically.
DOI: 10.6084/m9.figshare.5980396
title: Effects of dimethylsulfoxide and pentoxifylline in the vitality of cutaneous flaps in rats

description: ABSTRACT Objectives: to verify the influence of dimethylsulfoxide and pentoxifylline on the vitality of cutaneous flaps in rats and the tissue repair process. Methods: were studied 30 Wistar rats, submitting them to a 2cm wide by 8cm long dorsal cutaneous flap, of caudal base. We distributed the animals in three groups: Control Group (n=10) with application gauze moistened with 0.9% Saline in the flap bed for 30 seconds; Dimethylsulfoxide group (n=10), with administration of 1ml of 5% dimethylsulfoxide divided into five injections of 0.2ml in the transition of the flap segments; Pentoxifylline group (n=10), with administration of pentoxifylline 20mg/kg, diluted to 1ml and divided into five injections of 0.2ml in the transition of the flap segments. Drugs were administered intraoperatively, in a single dose and subcutaneously. We observed the skin flaps for changes in color and texture. On the 10th postoperative day, we checked the dimensions of viable and necrotic tissues, followed by excision of the specimen for histological analysis. Results: the measurements of length of the viable and necrotic tissues between groups showed no differences. Histological analysis showed that the Dimethylsulfoxide group presented neovascularization, inflammatory infiltrate with leukocytes and more structured conjunctival stroma. The Pentoxifylline group showed neovascularization and inflammatory infiltrate, with moderate to intense granulation. The control group evolved with a higher rate of necrosis in the distal segment. Conclusion: dimethylsulfoxide and pentoxifylline influenced the vitality of the flap and the tissue repair process. However, they did not prevent necrosis macroscopically.
DOI: 10.6084/m9.figshare.5980198.v1
title: Colon cancer surgery in patients operated on an emergency basis

description: ABSTRACT Objective: to study the epidemiological profile of patients with colorectal cancer operated on an emergency basis at the Bonsucesso Federal Hospital. Methods: this is a retrospective study of patients operated between January 1999 and December 2012. We analyzed the following variables: age, gender, clinical data, TMN staging, tumor location, survival and types of surgery. Results: we evaluated 130 patients in the study period. The most frequent clinical picture was intestinal obstruction, in 78% of cases. Intestinal perforation was the surgical indication in 15%. The majority (39%) of the patients had advanced TNM staging, compared with 27% in the initial stage. There were 39 deaths (30%) documented in the period. The most common tumor site was the sigmoid colon (51%), followed by the ascending colon (16%). The curative intent was performed in most cases, with adjuvant treatment being performed in 40% of the patients. Distant metastases were found in 42% of the patients and 10% had documented disease recurrence. Disease-free survival at two and five years was 69% and 41%, respectively. Conclusion: there was a high mortality rate and a low survival rate in colorectal cancer patients operated on urgently.
DOI: 10.6084/m9.figshare.5980198
title: Colon cancer surgery in patients operated on an emergency basis

description: ABSTRACT Objective: to study the epidemiological profile of patients with colorectal cancer operated on an emergency basis at the Bonsucesso Federal Hospital. Methods: this is a retrospective study of patients operated between January 1999 and December 2012. We analyzed the following variables: age, gender, clinical data, TMN staging, tumor location, survival and types of surgery. Results: we evaluated 130 patients in the study period. The most frequent clinical picture was intestinal obstruction, in 78% of cases. Intestinal perforation was the surgical indication in 15%. The majority (39%) of the patients had advanced TNM staging, compared with 27% in the initial stage. There were 39 deaths (30%) documented in the period. The most common tumor site was the sigmoid colon (51%), followed by the ascending colon (16%). The curative intent was performed in most cases, with adjuvant treatment being performed in 40% of the patients. Distant metastases were found in 42% of the patients and 10% had documented disease recurrence. Disease-free survival at two and five years was 69% and 41%, respectively. Conclusion: there was a high mortality rate and a low survival rate in colorectal cancer patients operated on urgently.
DOI: 10.6084/m9.figshare.5980090
title: Influence of the colon in liver regeneration of rats submitted to hepatectomy and colectomy

description: ABSTRACT Objective: to evaluate whether colectomy, associated with 70% hepatectomy, influences liver regeneration in rats. Methods: we distributed 18 Wistar rats in three groups of six animals each. In group I (sham), we performed laparotomy; In group II, colectomy + 70% hepatectomy; In group III, only 70% hepatectomy. On the 6th postoperative day, we collected blood by cardiac puncture under anesthesia, followed by euthanasia. We performed serum dosages of aspartate aminotransferase (AST), alanine aminotransferase (ALT), albumin and alkaline phosphatase (AF), hepatocyte growth factor (HGF) and transforming growth factor-α (TGF-α). We calculated liver regeneration by the formula: liver weight ratio per 100g body weight at the time of euthanasia / liver weight preoperatively projected for 100g body weight × 100. Results: ALT and AST levels were significantly lower in group II when compared with group III (p&lt;0.001). Albuminemia showed significantly higher levels in group II. Levels of HGF and TGF-α in group II were significantly higher than in group III. The percentage of hepatic regeneration was significantly higher in group II than in group III. Conclusion: Colectomy performed simultaneously with 70% hepatectomy had a positive influence on liver regeneration in rats. Further research is needed to reveal the molecular mechanisms of this effect and to characterize the colon influence in liver physiology.
DOI: 10.6084/m9.figshare.5980090.v1
title: Influence of the colon in liver regeneration of rats submitted to hepatectomy and colectomy

description: ABSTRACT Objective: to evaluate whether colectomy, associated with 70% hepatectomy, influences liver regeneration in rats. Methods: we distributed 18 Wistar rats in three groups of six animals each. In group I (sham), we performed laparotomy; In group II, colectomy + 70% hepatectomy; In group III, only 70% hepatectomy. On the 6th postoperative day, we collected blood by cardiac puncture under anesthesia, followed by euthanasia. We performed serum dosages of aspartate aminotransferase (AST), alanine aminotransferase (ALT), albumin and alkaline phosphatase (AF), hepatocyte growth factor (HGF) and transforming growth factor-α (TGF-α). We calculated liver regeneration by the formula: liver weight ratio per 100g body weight at the time of euthanasia / liver weight preoperatively projected for 100g body weight × 100. Results: ALT and AST levels were significantly lower in group II when compared with group III (p&lt;0.001). Albuminemia showed significantly higher levels in group II. Levels of HGF and TGF-α in group II were significantly higher than in group III. The percentage of hepatic regeneration was significantly higher in group II than in group III. Conclusion: Colectomy performed simultaneously with 70% hepatectomy had a positive influence on liver regeneration in rats. Further research is needed to reveal the molecular mechanisms of this effect and to characterize the colon influence in liver physiology.
DOI: 10.6084/m9.figshare.5980417
title: Development of a laparoscopic training model using a smartphone

description: ABSTRACT Objective: to develop a model of training in video-surgery, of low cost and that uses a smartphone as an image-generating source. Methods: We developed a 38cm high, 40cm wide, 40cm long hexagonal-shaped training box, with a front opening of 12x8 cm for coupling the smartphone. The internal illumination is made with LED lamps and for the support of the smartphone, we used a selfie stick, fixed in the upper part of the box, that allows control of height, distance, angulation, and the coupling of devices with different formats. We selected 20 undergraduate students without previous training in video-surgery, who performed four exercises in the box, with assessment of the time and amount of errors in the execution of the tasks. Each student completed the training for three consecutive weeks. We collected the data in spreadsheets for later analysis. Results: Nineteen students completed the training program, with significant improvement in the times and in the number of errors. Conclusion: the developed model was feasible and promoted the acquisition of skills in this group of students. In addition, it presents low cost, is portable and uses common equipment, such as smartphones.
DOI: 10.6084/m9.figshare.5980417.v1
title: Development of a laparoscopic training model using a smartphone

description: ABSTRACT Objective: to develop a model of training in video-surgery, of low cost and that uses a smartphone as an image-generating source. Methods: We developed a 38cm high, 40cm wide, 40cm long hexagonal-shaped training box, with a front opening of 12x8 cm for coupling the smartphone. The internal illumination is made with LED lamps and for the support of the smartphone, we used a selfie stick, fixed in the upper part of the box, that allows control of height, distance, angulation, and the coupling of devices with different formats. We selected 20 undergraduate students without previous training in video-surgery, who performed four exercises in the box, with assessment of the time and amount of errors in the execution of the tasks. Each student completed the training for three consecutive weeks. We collected the data in spreadsheets for later analysis. Results: Nineteen students completed the training program, with significant improvement in the times and in the number of errors. Conclusion: the developed model was feasible and promoted the acquisition of skills in this group of students. In addition, it presents low cost, is portable and uses common equipment, such as smartphones.
DOI: 10.5281/zenodo.6606082
title: Data associated with the paper "Exploiting Color space geometry for visual stimulus design across animals"

description: These are the pickled data files (pickled using pandas.DataFrame objects in Python) associated with the supplementary figures S4 and S7. * amp_1155: Data for S4B * amp_1156: Data for S4A * amp_518: Data for S7C-D * amp_529: Data for S7E-F
DOI: 10.5281/zenodo.6606081
title: Data associated with the paper "Exploiting Color space geometry for visual stimulus design across animals"

description: These are the pickled data files (pickled using pandas.DataFrame objects in Python) associated with the supplementary figures S4 and S7. * amp_1155: Data for S4B * amp_1156: Data for S4A * amp_518: Data for S7C-D * amp_529: Data for S7E-F
DOI: 10.6084/m9.figshare.19959583
title: Additional file 10 of Leveraging transcriptome and epigenome landscapes to infer regulatory networks during the onset of sexual maturation

description: Additional file 10.
DOI: 10.6084/m9.figshare.19959583.v1
title: Additional file 10 of Leveraging transcriptome and epigenome landscapes to infer regulatory networks during the onset of sexual maturation

description: Additional file 10.
DOI: 10.6084/m9.figshare.19959589
title: Additional file 2 of Leveraging transcriptome and epigenome landscapes to infer regulatory networks during the onset of sexual maturation

description: Additional file 2.
DOI: 10.6084/m9.figshare.19959589.v1
title: Additional file 2 of Leveraging transcriptome and epigenome landscapes to infer regulatory networks during the onset of sexual maturation

description: Additional file 2.
DOI: 10.6084/m9.figshare.19959592
title: Additional file 3 of Leveraging transcriptome and epigenome landscapes to infer regulatory networks during the onset of sexual maturation

description: Additional file 3.
DOI: 10.6084/m9.figshare.19959592.v1
title: Additional file 3 of Leveraging transcriptome and epigenome landscapes to infer regulatory networks during the onset of sexual maturation

description: Additional file 3.
DOI: 10.6084/m9.figshare.19959595
title: Additional file 4 of Leveraging transcriptome and epigenome landscapes to infer regulatory networks during the onset of sexual maturation

description: Additional file 4.
DOI: 10.6084/m9.figshare.19959595.v1
title: Additional file 4 of Leveraging transcriptome and epigenome landscapes to infer regulatory networks during the onset of sexual maturation

description: Additional file 4.
DOI: 10.6084/m9.figshare.19959598
title: Additional file 5 of Leveraging transcriptome and epigenome landscapes to infer regulatory networks during the onset of sexual maturation

description: Additional file 5.
DOI: 10.6084/m9.figshare.19959598.v1
title: Additional file 5 of Leveraging transcriptome and epigenome landscapes to infer regulatory networks during the onset of sexual maturation

description: Additional file 5.
DOI: 10.6084/m9.figshare.19959601
title: Additional file 6 of Leveraging transcriptome and epigenome landscapes to infer regulatory networks during the onset of sexual maturation

description: Additional file 6.
DOI: 10.6084/m9.figshare.19959604
title: Additional file 7 of Leveraging transcriptome and epigenome landscapes to infer regulatory networks during the onset of sexual maturation

description: Additional file 7.
DOI: 10.6084/m9.figshare.19959601.v1
title: Additional file 6 of Leveraging transcriptome and epigenome landscapes to infer regulatory networks during the onset of sexual maturation

description: Additional file 6.
DOI: 10.6084/m9.figshare.19959604.v1
title: Additional file 7 of Leveraging transcriptome and epigenome landscapes to infer regulatory networks during the onset of sexual maturation

description: Additional file 7.
DOI: 10.6084/m9.figshare.19959607
title: Additional file 8 of Leveraging transcriptome and epigenome landscapes to infer regulatory networks during the onset of sexual maturation

description: Additional file 8.
DOI: 10.6084/m9.figshare.19959610
title: Additional file 9 of Leveraging transcriptome and epigenome landscapes to infer regulatory networks during the onset of sexual maturation

description: Additional file 9.
DOI: 10.6084/m9.figshare.19959610.v1
title: Additional file 9 of Leveraging transcriptome and epigenome landscapes to infer regulatory networks during the onset of sexual maturation

description: Additional file 9.
DOI: 10.6084/m9.figshare.19959607.v1
title: Additional file 8 of Leveraging transcriptome and epigenome landscapes to infer regulatory networks during the onset of sexual maturation

description: Additional file 8.
DOI: 10.6084/m9.figshare.19959641
title: Additional file 10 of Introducing conflict resolution and negotiation training into a biomedical sciences graduate curriculum

description: Additional file 10.
DOI: 10.6084/m9.figshare.19959641.v1
title: Additional file 10 of Introducing conflict resolution and negotiation training into a biomedical sciences graduate curriculum

description: Additional file 10.
DOI: 10.6084/m9.figshare.19959644
title: Additional file 1 of Introducing conflict resolution and negotiation training into a biomedical sciences graduate curriculum

description: Additional file 1.
DOI: 10.6084/m9.figshare.19959644.v1
title: Additional file 1 of Introducing conflict resolution and negotiation training into a biomedical sciences graduate curriculum

description: Additional file 1.
DOI: 10.6084/m9.figshare.19959647
title: Additional file 2 of Introducing conflict resolution and negotiation training into a biomedical sciences graduate curriculum

description: Additional file 2.
DOI: 10.6084/m9.figshare.19959647.v1
title: Additional file 2 of Introducing conflict resolution and negotiation training into a biomedical sciences graduate curriculum

description: Additional file 2.
DOI: 10.6084/m9.figshare.19959650
title: Additional file 3 of Introducing conflict resolution and negotiation training into a biomedical sciences graduate curriculum

description: Additional file 3.
DOI: 10.6084/m9.figshare.19959650.v1
title: Additional file 3 of Introducing conflict resolution and negotiation training into a biomedical sciences graduate curriculum

description: Additional file 3.
DOI: 10.6084/m9.figshare.19959653
title: Additional file 4 of Introducing conflict resolution and negotiation training into a biomedical sciences graduate curriculum

description: Additional file 4.
DOI: 10.6084/m9.figshare.19959656
title: Additional file 5 of Introducing conflict resolution and negotiation training into a biomedical sciences graduate curriculum

description: Additional file 5.
DOI: 10.6084/m9.figshare.19959653.v1
title: Additional file 4 of Introducing conflict resolution and negotiation training into a biomedical sciences graduate curriculum

description: Additional file 4.
DOI: 10.6084/m9.figshare.19959656.v1
title: Additional file 5 of Introducing conflict resolution and negotiation training into a biomedical sciences graduate curriculum

description: Additional file 5.
DOI: 10.6084/m9.figshare.19959659
title: Additional file 6 of Introducing conflict resolution and negotiation training into a biomedical sciences graduate curriculum

description: Additional file 6.
DOI: 10.6084/m9.figshare.19959659.v1
title: Additional file 6 of Introducing conflict resolution and negotiation training into a biomedical sciences graduate curriculum

description: Additional file 6.
DOI: 10.6084/m9.figshare.19959665.v1
title: Additional file 8 of Introducing conflict resolution and negotiation training into a biomedical sciences graduate curriculum

description: Additional file 8.
DOI: 10.6084/m9.figshare.19959668
title: Additional file 9 of Introducing conflict resolution and negotiation training into a biomedical sciences graduate curriculum

description: Additional file 9.
DOI: 10.6084/m9.figshare.19959665
title: Additional file 8 of Introducing conflict resolution and negotiation training into a biomedical sciences graduate curriculum

description: Additional file 8.
DOI: 10.6084/m9.figshare.19959668.v1
title: Additional file 9 of Introducing conflict resolution and negotiation training into a biomedical sciences graduate curriculum

description: Additional file 9.
DOI: 10.6084/m9.figshare.13889346.v1
title: Additional file 1 of Cadence (steps/min) and relative intensity in 21 to 60-year-olds: the CADENCE-adults study

description: Additional file 1: Spreadsheet displaying final analytical dataset.
DOI: 10.6084/m9.figshare.13889346
title: Additional file 1 of Cadence (steps/min) and relative intensity in 21 to 60-year-olds: the CADENCE-adults study

description: Additional file 1: Spreadsheet displaying final analytical dataset.