cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.22638383.v1
title: Immunochromatography screening devices for cannabinoids in oral fluid sample

description: Abstract Cannabis sativa L. is one of the most consumed drugs in the world and recent studies have associated its use with an increase in the number of traffic accidents in different countries. In many countries, like Brazil, simple and reliable methodologies are still needed for the detection of drugs on site, mainly cannabinoids, considering its prevalence of use and oral fluid (OF) has been proved as an appropriate biological matrix for this purpose. Considering that, this work aims to review previous studies on immunochromatographic devices for on-site detection of cannabinoids in OF, discussing their sensitivity, specificity, cut-offs values and confirmatory methods. This data shows the importance of choosing a screening device and it reinforces the need for its implementation in Brazil. The research was conducted on 5 databases and all original articles, published in the last 10 years, were selected. A total of 32 articles were found, providing data for 17 screening devices of distinct brands. Only 2 screening devices showed satisfactory sensitivity and specificity in the evaluated studies (≥80% and ≥90% respectively). However, it should be considered that the screening devices still have some limitations, such as a higher cut-off than those recommended by international guidelines (cut-off &gt; 2 ng/mL), therefore demonstrating the need for more studies in the area and the importance of confirmatory analysis usually fulfilled by LC-MS/MS, GC-MS/MS or GC-MS. Thus, the screening analyzes should not be evaluated by itself, but in association with confirmatory results and observational traits (behavioral changes), for a better understanding of the traffic scenario.
DOI: 10.6084/m9.figshare.14317681
title: microRNA-130b downregulation potentiates chondrogenic differentiation of bone marrow mesenchymal stem cells by targeting SOX9

description: Osteoarthritis (OA) is a chronic health condition. MicroRNAs (miRs) are critical in chondrocyte apoptosis in OA. We aimed to investigate the mechanism of miR-130b in OA progression. Bone marrow mesenchymal stem cells (BMSCs) and chondrocytes were first extracted. Chondrogenic differentiation of BMSCs was carried out and verified. Chondrocytes were stimulated with interleukin (IL)-1β to imitate OA condition in vitro. The effect of miR-130b on the viability, inflammation, apoptosis, and extracellular matrix of OA chondrocytes was studied. The target gene of miR-130b was predicted and verified. Rescue experiments were performed to further study the underlying downstream mechanism of miR-130b in OA. miR-130b first increased and drastically reduced during chondrogenic differentiation of BMSCs and in OA chondrocytes, respectively, while IL-1β stimulation resulted in increased miR-130b expression in chondrocytes. miR-130b inhibitor promoted chondrogenic differentiation of BMSCs and chondrocyte growth and inhibited the levels of inflammatory factors. miR-130b targeted SOX9. Overexpression of SOX9 facilitated BMSC chondrogenic differentiation and chondrocyte growth, while siRNA-SOX9 contributed to the opposite trends. Silencing of SOX9 significantly attenuated the pro-chondrogenic effects of miR-130b inhibitor on BMSCs. Overall, miR-130b inhibitor induced chondrogenic differentiation of BMSCs and chondrocyte growth by targeting SOX9.
DOI: 10.6084/m9.figshare.14317681.v1
title: microRNA-130b downregulation potentiates chondrogenic differentiation of bone marrow mesenchymal stem cells by targeting SOX9

description: Osteoarthritis (OA) is a chronic health condition. MicroRNAs (miRs) are critical in chondrocyte apoptosis in OA. We aimed to investigate the mechanism of miR-130b in OA progression. Bone marrow mesenchymal stem cells (BMSCs) and chondrocytes were first extracted. Chondrogenic differentiation of BMSCs was carried out and verified. Chondrocytes were stimulated with interleukin (IL)-1β to imitate OA condition in vitro. The effect of miR-130b on the viability, inflammation, apoptosis, and extracellular matrix of OA chondrocytes was studied. The target gene of miR-130b was predicted and verified. Rescue experiments were performed to further study the underlying downstream mechanism of miR-130b in OA. miR-130b first increased and drastically reduced during chondrogenic differentiation of BMSCs and in OA chondrocytes, respectively, while IL-1β stimulation resulted in increased miR-130b expression in chondrocytes. miR-130b inhibitor promoted chondrogenic differentiation of BMSCs and chondrocyte growth and inhibited the levels of inflammatory factors. miR-130b targeted SOX9. Overexpression of SOX9 facilitated BMSC chondrogenic differentiation and chondrocyte growth, while siRNA-SOX9 contributed to the opposite trends. Silencing of SOX9 significantly attenuated the pro-chondrogenic effects of miR-130b inhibitor on BMSCs. Overall, miR-130b inhibitor induced chondrogenic differentiation of BMSCs and chondrocyte growth by targeting SOX9.
DOI: 10.6084/m9.figshare.22638386
title: A new species of Rineloricaria (Siluriformes: Loricariidae) from coastal drainages of Rio de Janeiro, southeastern Brazil

description: Abstract A new species of Rineloricaria is described from the Iguaçu, Magé, Saracuruna, Guapiaçu, Macacu, Macaé, and Paraíba do Sul River basins in southeastern Brazil based on morphological and molecular data. The new species is diagnosed among congeners by the combination of the following characters: absence of plates in most of the ventral surface of pectoral girdle; snout tip with elliptical naked area reaching posteriorly the anteriormost pore of the infraorbital ramus of sensory canal; dorsal-fin spinelet present; supraoccipital and predorsal plates with smooth keels; five series of lateral plates below the dorsal fin; median and mid-ventral series of plates with well-developed keels. The new species is distinguished from congeners that inhabit the rivers draining the Serra do Mar in Rio de Janeiro state by the partial plate coverage of the ventral surface of the pectoral girdle and the abdomen (vs. pectoral girdle and abdomen completely covered by plates in Rineloricaria nigricauda, R. steindachneri, and R. zawadzkii). The new species shares the absence of plates on the abdominal surface with other species from the Paraná, Uruguay, and other Brazilian coastal river basins.
DOI: 10.6084/m9.figshare.22638386.v1
title: A new species of Rineloricaria (Siluriformes: Loricariidae) from coastal drainages of Rio de Janeiro, southeastern Brazil

description: Abstract A new species of Rineloricaria is described from the Iguaçu, Magé, Saracuruna, Guapiaçu, Macacu, Macaé, and Paraíba do Sul River basins in southeastern Brazil based on morphological and molecular data. The new species is diagnosed among congeners by the combination of the following characters: absence of plates in most of the ventral surface of pectoral girdle; snout tip with elliptical naked area reaching posteriorly the anteriormost pore of the infraorbital ramus of sensory canal; dorsal-fin spinelet present; supraoccipital and predorsal plates with smooth keels; five series of lateral plates below the dorsal fin; median and mid-ventral series of plates with well-developed keels. The new species is distinguished from congeners that inhabit the rivers draining the Serra do Mar in Rio de Janeiro state by the partial plate coverage of the ventral surface of the pectoral girdle and the abdomen (vs. pectoral girdle and abdomen completely covered by plates in Rineloricaria nigricauda, R. steindachneri, and R. zawadzkii). The new species shares the absence of plates on the abdominal surface with other species from the Paraná, Uruguay, and other Brazilian coastal river basins.
DOI: 10.6084/m9.figshare.22638387
title: Determinants of successful labor induction in a teaching hospital in Nigeria: a 10-year review

description: Abstract Objectives: to evaluate the success rate of labor induction and determinants of successful outcome. Methods: retrospective cohort study of parturients that undergone labor induction between 2006 and 2015. Data was retrieved from the medical records and multivariate logistic regression was used to evaluate the determinants of successful labor induction. Results: the rate of labor induction was 10.9%. Out of the 940 women analysed, six hundred and fifty-six women (69.8%) had successful vaginal delivery. Labor induction at 39-40 weeks (OR=2.70; CI95%=1.17-6.36), 41 weeks (OR=2.44; CI95%=1.14-5.28), estimated fetal weight between 2.5 and 3.4kg (OR=4.27, CI95%=1.96-5.59) and estimated fetal weight of 3.5-3.9kg (OR=5.45; CI95%=2.81-10.60) increased the odds of achieving vaginal delivery. Conclusions: our findings suggest that 39, 40 and 41 weeks are optimal gestational ages for labor induction with respect to successful vaginal delivery. Also, estimated fetal weight between 2.5kg and 3.9kg favours successful vaginal delivery.
DOI: 10.6084/m9.figshare.22638387.v1
title: Determinants of successful labor induction in a teaching hospital in Nigeria: a 10-year review

description: Abstract Objectives: to evaluate the success rate of labor induction and determinants of successful outcome. Methods: retrospective cohort study of parturients that undergone labor induction between 2006 and 2015. Data was retrieved from the medical records and multivariate logistic regression was used to evaluate the determinants of successful labor induction. Results: the rate of labor induction was 10.9%. Out of the 940 women analysed, six hundred and fifty-six women (69.8%) had successful vaginal delivery. Labor induction at 39-40 weeks (OR=2.70; CI95%=1.17-6.36), 41 weeks (OR=2.44; CI95%=1.14-5.28), estimated fetal weight between 2.5 and 3.4kg (OR=4.27, CI95%=1.96-5.59) and estimated fetal weight of 3.5-3.9kg (OR=5.45; CI95%=2.81-10.60) increased the odds of achieving vaginal delivery. Conclusions: our findings suggest that 39, 40 and 41 weeks are optimal gestational ages for labor induction with respect to successful vaginal delivery. Also, estimated fetal weight between 2.5kg and 3.9kg favours successful vaginal delivery.
DOI: 10.6084/m9.figshare.22638389.v1
title: Predictive Factors of Tolerance in Office Hysteroscopy - a 3-Year Analysis from a Tertiary Center

description: Abstract Objective Pain is the primary limitation to performing hysteroscopy. We aimed to evaluate the predictive factors of low tolerance to office hysteroscopic procedures. Methods Retrospective cohort study of the patients who underwent office hysteroscopy from January 2018 to December 2020 at a tertiary care center. Pain tolerance to office-based hysteroscopy was subjectively assessed by the operator as terrible, poor, moderate, good, or excellent. Categorical variables were compared with the use of the Chi-squared test; an independent-samples t-test was conducted to compare continuous variables. Logistic regression was performed to determine the main factors associated with low procedure tolerance. Results A total of 1,418 office hysteroscopies were performed. The mean age of the patients was 53 ± 13.8 years; 50.8% of women were menopausal, 17.8% were nulliparous, and 68.7% had a previous vaginal delivery. A total of 42.6% of women were submitted to an operative hysteroscopy. Tolerance was categorized as terrible or poor in 14.9% of hysteroscopies and moderate, good, or excellent in 85.1%. A terrible or poor tolerance was more frequently reported in menopausal women (18.1% vs. 11.7% in premenopausal women, p = 0.001) and women with no previous vaginal delivery (18.8% vs. 12.9% in women with at least one vaginal birth, p = 0.007). Low tolerance led more often to scheduling a second hysteroscopic procedure under anesthesia (56.4% vs. 17.5% in reasonable-to-excellent tolerance, p &lt; 0.0005). Conclusion Office hysteroscopy was a well-tolerated procedure in our experience, but menopause and lack of previous vaginal delivery were associated with low tolerance. These patients are more likely to benefit from pain relief measures during office hysteroscopy.
DOI: 10.6084/m9.figshare.22638389
title: Predictive Factors of Tolerance in Office Hysteroscopy - a 3-Year Analysis from a Tertiary Center

description: Abstract Objective Pain is the primary limitation to performing hysteroscopy. We aimed to evaluate the predictive factors of low tolerance to office hysteroscopic procedures. Methods Retrospective cohort study of the patients who underwent office hysteroscopy from January 2018 to December 2020 at a tertiary care center. Pain tolerance to office-based hysteroscopy was subjectively assessed by the operator as terrible, poor, moderate, good, or excellent. Categorical variables were compared with the use of the Chi-squared test; an independent-samples t-test was conducted to compare continuous variables. Logistic regression was performed to determine the main factors associated with low procedure tolerance. Results A total of 1,418 office hysteroscopies were performed. The mean age of the patients was 53 ± 13.8 years; 50.8% of women were menopausal, 17.8% were nulliparous, and 68.7% had a previous vaginal delivery. A total of 42.6% of women were submitted to an operative hysteroscopy. Tolerance was categorized as terrible or poor in 14.9% of hysteroscopies and moderate, good, or excellent in 85.1%. A terrible or poor tolerance was more frequently reported in menopausal women (18.1% vs. 11.7% in premenopausal women, p = 0.001) and women with no previous vaginal delivery (18.8% vs. 12.9% in women with at least one vaginal birth, p = 0.007). Low tolerance led more often to scheduling a second hysteroscopic procedure under anesthesia (56.4% vs. 17.5% in reasonable-to-excellent tolerance, p &lt; 0.0005). Conclusion Office hysteroscopy was a well-tolerated procedure in our experience, but menopause and lack of previous vaginal delivery were associated with low tolerance. These patients are more likely to benefit from pain relief measures during office hysteroscopy.
DOI: 10.6084/m9.figshare.22638392
title: Integrative and Complementary Practices in Health: the (in)complete construction of the policy in a large city in Brazil

description: ABSTRACT The objective of this study was to analyze the process of implementation, the current situation and perspectives of the Homeopathy, Acupuncture and Anthroposophical Medicine Program (PRHOAMA) in public health service in Belo Horizonte (Brazil) considering the guidelines of the National Policy for Integrative and Complementary Practices (PNPIC). The case study was carried out through document analysis of 32 official texts, secondary data (number of professionals and procedures offered) in health information systems and a focus group with professionals of PRHOAMA. The program was implemented in 1994, in Basic Health Units (UBS), configuring itself as a pioneering experience in Brazil. Practices are performed exclusively by physicians, which diverges from the recommendations of the PNPIC, whose recommended the ideal model is multi-professional. PRHOAMA’s institutionalization process is partial, not constituting a consolidated public policy. PRHOAMA complies with the PNPIC guidelines, such as emphasis on Primary Care, dissemination and information about Complementary Therapies. However, it is necessary to advance in the promotion of access to homeopathic medicines, in the definition of financing mechanisms and in the expansion of the management team and professionals.
DOI: 10.6084/m9.figshare.22638392.v1
title: Integrative and Complementary Practices in Health: the (in)complete construction of the policy in a large city in Brazil

description: ABSTRACT The objective of this study was to analyze the process of implementation, the current situation and perspectives of the Homeopathy, Acupuncture and Anthroposophical Medicine Program (PRHOAMA) in public health service in Belo Horizonte (Brazil) considering the guidelines of the National Policy for Integrative and Complementary Practices (PNPIC). The case study was carried out through document analysis of 32 official texts, secondary data (number of professionals and procedures offered) in health information systems and a focus group with professionals of PRHOAMA. The program was implemented in 1994, in Basic Health Units (UBS), configuring itself as a pioneering experience in Brazil. Practices are performed exclusively by physicians, which diverges from the recommendations of the PNPIC, whose recommended the ideal model is multi-professional. PRHOAMA’s institutionalization process is partial, not constituting a consolidated public policy. PRHOAMA complies with the PNPIC guidelines, such as emphasis on Primary Care, dissemination and information about Complementary Therapies. However, it is necessary to advance in the promotion of access to homeopathic medicines, in the definition of financing mechanisms and in the expansion of the management team and professionals.
DOI: 10.6084/m9.figshare.22638393
title: Permanent health education in the context of obesity: a scoping review

description: ABSTRACT OBJETIVE To map the international literature on Permanent Health Education initiatives to care for people with obesity. METHODS In total, six databases were searched without any language or publication period restriction according to the Joana Briggs Institute manual for evidence synthesis and the Prisma extension for scoping reviews (Prisma-ScR). Articles were independently analyzed by four reviewers and data, by two authors, which were then analyzed and discussed with our research team. RESULTS After screening 8,780 titles/abstracts and 26 full texts, 10studies met our eligibility criteria. We extracted data on methodologies, themes, definitions of obesity, outcomes, and gaps. Most initiatives came from North American countries without free or universal health systems and lasted a short period of time (70%), had multidisciplinary teams (70%), and addressed sub-themes on obesity approaches (90%). Results included changes in participants’ understanding, attitude, and procedures (80%) and gaps which pointed to the sustainability of these changes (80%). CONCLUSION This review shows the scarce research in the area and a general design of poorly effective initiatives, with traditional teaching methodologies based on information transmission techniques, the understanding of obesity as a disease and a public health problem, punctual actions, disciplinary fragmentation alien to the daily work centrality, and failure to recognize problems and territory as knowledge triggers and to focus on health care networks, line of care, the integrality of care, and food and body cultures.
DOI: 10.6084/m9.figshare.22638393.v1
title: Permanent health education in the context of obesity: a scoping review

description: ABSTRACT OBJETIVE To map the international literature on Permanent Health Education initiatives to care for people with obesity. METHODS In total, six databases were searched without any language or publication period restriction according to the Joana Briggs Institute manual for evidence synthesis and the Prisma extension for scoping reviews (Prisma-ScR). Articles were independently analyzed by four reviewers and data, by two authors, which were then analyzed and discussed with our research team. RESULTS After screening 8,780 titles/abstracts and 26 full texts, 10studies met our eligibility criteria. We extracted data on methodologies, themes, definitions of obesity, outcomes, and gaps. Most initiatives came from North American countries without free or universal health systems and lasted a short period of time (70%), had multidisciplinary teams (70%), and addressed sub-themes on obesity approaches (90%). Results included changes in participants’ understanding, attitude, and procedures (80%) and gaps which pointed to the sustainability of these changes (80%). CONCLUSION This review shows the scarce research in the area and a general design of poorly effective initiatives, with traditional teaching methodologies based on information transmission techniques, the understanding of obesity as a disease and a public health problem, punctual actions, disciplinary fragmentation alien to the daily work centrality, and failure to recognize problems and territory as knowledge triggers and to focus on health care networks, line of care, the integrality of care, and food and body cultures.
DOI: 10.6084/m9.figshare.22638396
title: Physiological responses of sugar-apple seedlings under saline wastewater irrigation and NPK doses

description: ABSTRACT Salt stress stands out as one of the main limiting factors in agricultural production in arid and semi-arid regions, due to its osmotic and ionic effects on plants. In this context, the objective was to evaluate the physiological responses of sugar-apple seedlings irrigated with saline wastewater under different doses of NPK. The experiment was carried out in a greenhouse, in a randomized block design, in a 3 x 5 factorial scheme, with four replicates. Three irrigation waters were tested: local-supply water (control), reject brine and fish farming effluent, and five doses of NPK, referring to the proportions of 25, 50, 75, 100, and 125% of the N:P:K fertilizer recommendation of 100:300:150 mg dm-3. Seedlings were cultivated in 2-dm3 containers filled with sandy soil for 90 days after sowing. At the end of this period, gas exchange, chlorophyll fluorescence, and biomass accumulation were evaluated. The use of reject brine and fish farming effluent to irrigate sugar-apple seedlings reduced photosynthetic activity and biomass accumulation. The best physiological responses and biomass accumulation occur at NPK doses of 75% (75:225:112.5 mg dm-3 of N:P:K) for seedlings irrigated with local-supply water, 60% (60:180: 90 mg dm-3 of N:P:K) for seedlings irrigated with reject brine, and 40% (40:120:60 mg dm-3 of N:P:K) for seedlings irrigated with fish farming effluent.
DOI: 10.6084/m9.figshare.22638396.v1
title: Physiological responses of sugar-apple seedlings under saline wastewater irrigation and NPK doses

description: ABSTRACT Salt stress stands out as one of the main limiting factors in agricultural production in arid and semi-arid regions, due to its osmotic and ionic effects on plants. In this context, the objective was to evaluate the physiological responses of sugar-apple seedlings irrigated with saline wastewater under different doses of NPK. The experiment was carried out in a greenhouse, in a randomized block design, in a 3 x 5 factorial scheme, with four replicates. Three irrigation waters were tested: local-supply water (control), reject brine and fish farming effluent, and five doses of NPK, referring to the proportions of 25, 50, 75, 100, and 125% of the N:P:K fertilizer recommendation of 100:300:150 mg dm-3. Seedlings were cultivated in 2-dm3 containers filled with sandy soil for 90 days after sowing. At the end of this period, gas exchange, chlorophyll fluorescence, and biomass accumulation were evaluated. The use of reject brine and fish farming effluent to irrigate sugar-apple seedlings reduced photosynthetic activity and biomass accumulation. The best physiological responses and biomass accumulation occur at NPK doses of 75% (75:225:112.5 mg dm-3 of N:P:K) for seedlings irrigated with local-supply water, 60% (60:180: 90 mg dm-3 of N:P:K) for seedlings irrigated with reject brine, and 40% (40:120:60 mg dm-3 of N:P:K) for seedlings irrigated with fish farming effluent.