cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.8088200.v1
title: Supplementary Material for: Direct Admission versus Secondary Transfer for Acute Stroke Patients Treated with Intravenous Thrombolysis and Thrombectomy: Insights from the Endovascular Treatment in Ischemic Stroke Registry

description: <b><i>Background:</i></b> To date, thrombectomy for large vessel occlusion (LVO) strokes can be performed only in comprehensive stroke centers with thrombectomy capacity. We compared the clinical outcome of patients first referred to a primary stroke center to those admitted directly to a comprehensive stroke center and treated on site in the multicentric observational Endovascular Treatment in Ischemic Stroke (ETIS) registry. <b><i>Methods:</i></b> From our perspective, multicenter, observational ETIS registry, we analyzed anterior circulation stroke patients, treated within 8 h, who underwent thrombectomy after thrombolysis and were admitted to a comprehensive stroke center either with drip and ship or mothership. Clinical and safety outcomes were compared between 2 groups. <b><i>Results:</i></b> A total of 971 patients were analyzed: 298 were treated with the mothership approach and 673 with drip and ship. Significantly more functional independence (90-day modified Rankin Scale [mRS] 0–2) was achieved in mothership (60.1%) than in drip and ship patients (52.6%; adjusted relative risk [RR] 0.87, 95% CI 0.77–0.98, <i>p</i> = 0.018). Excellent outcome (90-day mRS 0–1) was achieved in 45.3% of the mothership group, compared to 37.9% of the drip and ship group (RR 0.84, 95% CI 0.71–0.98; <i>p</i> = 0.026). According to the distance between the primary stroke center and the comprehensive stroke center, greater functional independence was achieved in mothership than in drip and ship &gt;12.5 miles patients (adjusted RR 0.82; 95% CI 0.71–0.94). Results in the drip-ship group stratified according to time between cerebral imaging and groin puncture (categorized according to the median cut-off: 140 min) were similar. Symptomatic intracerebral hemorrhage rate and mortality within 90 days was similar in both groups (7.5 vs. 5.9%, <i>p</i> = 0.40; 17.4 vs. 16.1%, <i>p</i> = 0.63). <b><i>Conclusions:</i></b> Our study suggests that LVO stroke patients directly admitted to a comprehensive stroke center present a higher chance of functional independence, especially when the distance between the primary stroke center and comprehensive stroke center is &gt;12.5 miles or when the time between cerebral imaging and groin puncture is ≥140 min.
DOI: 10.6084/m9.figshare.8088167
title: Photographies and measurement files for "Measurement and analysis of partial lightning currents in a head phantom"

description: The files support the article "Measurement and analysis of partial lightning currents in a head phantom" from Plos One. We included photographies and measurement files.<br>
DOI: 10.6084/m9.figshare.8088167.v1
title: Photographies and measurement files for "Measurement and analysis of partial lightning currents in a head phantom"

description: The files support the article "Measurement and analysis of partial lightning currents in a head phantom" from Plos One. We included photographies and measurement files.<br>
DOI: 10.6084/m9.figshare.8088110
title: Cigarette smoke-induced reduction of C1q promotes emphysema

description: <b>Overview</b><b><br></b>Alteration of innate immune cells in the lungs can promote loss of peripheral tolerance that leads to autoimmune responses in cigarette smokers. Development of autoimmunity in smokers with emphysema is also strongly linked to the expansion of autoreactive T helper (Th) cells expressing interferon gamma (Th1), and interleukin 17A (Th17). However, the mechanisms responsible for enhanced self-recognition and reduced immune tolerance in smoker with emphysema remain less clear. Here we show that C1q, a component of the complement protein 1 complex (C1), is downregulated in lung CD1a+ antigen presenting cells (APCs) isolated from emphysematous human, and mouse lung APCs after chronic cigarette smoke exposure. C1q potentiated the function of APCs to differentiate CD4+ T cells to Tregs, while it inhibited Th17 cell development and proliferation. Mice deficient in C1q that were exposed to chronic smoke exhibited exaggerated lung inflammation marked by increased Th17 cells, while reconstitution of C1q in the lungs enhanced Tregs abundance, dampened smoke-induced lung inflammation, and reversed established emphysema. Our findings demonstrate that cigarette smoke-mediated loss of C1q could play a key role in reduced peripheral tolerance, which could be explored to treat emphysema.<br><b>Dataset</b><b><br></b>Human CD4+ T cells were isolated from PBMC and cultured with vehicle (no treatment; NT), C1q, TGFb with or without C1q for 48 hours. Total RNA was isolated from the cells and subjected to RNA-Seq using standard protocols. Data was mapped using TopHat to UCSC hg19 genome build, and quantified using cufflinks as FPKM (fragments per kilobase per million mapped reads). <br><b>Publication</b><b><br></b>Xiaoyi Yuan, Cheng-Yen Chang, Ran You, Ming Shan, Bon Hee Gu, Matthew Madison, Gretchen Diehl, Sarah Perusich, Li-Zhen Song, Lorraine Cornwell, Roger D. Rossen, Rick Wetsel, Rajapakshe Kimal, Cristian Coarfa, Holger Eltzschig, David B. Corry, Farrah Kheradmand. Cigarette smoke-induced reduction of C1q promotes emphysema. <b>JCI Insight. </b><br>
DOI: 10.6084/m9.figshare.8088086
title: Additional file 4: of Metabolic characterization of the chitinolytic bacterium Serratia marcescens using a genome-scale metabolic model

description: Exchange file. (TXT 2 kb)
DOI: 10.6084/m9.figshare.8088089
title: Additional file 5: of Metabolic characterization of the chitinolytic bacterium Serratia marcescens using a genome-scale metabolic model

description: GPR file. (TXT 199 kb)
DOI: 10.6084/m9.figshare.8088080
title: Additional file 3: of Metabolic characterization of the chitinolytic bacterium Serratia marcescens using a genome-scale metabolic model

description: Biomass objective function file. (TXT 1 kb)
DOI: 10.6084/m9.figshare.8088089.v1
title: Additional file 5: of Metabolic characterization of the chitinolytic bacterium Serratia marcescens using a genome-scale metabolic model

description: GPR file. (TXT 199 kb)
DOI: 10.6084/m9.figshare.8088080.v1
title: Additional file 3: of Metabolic characterization of the chitinolytic bacterium Serratia marcescens using a genome-scale metabolic model

description: Biomass objective function file. (TXT 1 kb)
DOI: 10.6084/m9.figshare.8088086.v1
title: Additional file 4: of Metabolic characterization of the chitinolytic bacterium Serratia marcescens using a genome-scale metabolic model

description: Exchange file. (TXT 2 kb)
DOI: 10.6084/m9.figshare.8088065
title: Additional file 6 of GeneSurrounder: network-based identification of disease genes in expression data

description: Table of the full results of GeneSurrounder applied to GSE32894. (CSV 362 kb)
DOI: 10.6084/m9.figshare.8088068
title: Additional file 2: of Metabolic characterization of the chitinolytic bacterium Serratia marcescens using a genome-scale metabolic model

description: Model file. (TXT 116 kb)
DOI: 10.6084/m9.figshare.8088056
title: Additional file 1: of Metabolic characterization of the chitinolytic bacterium Serratia marcescens using a genome-scale metabolic model

description: Table S1. Average RPKM values of S. marcescens gene expression level at three different growth conditions. Table S2. Number of genes excluded/included after the lower/upper bound cutoff. Table S3. S.marcescens iSR929 reaction flux values after running Ruppin algorithm. Table S4. NAD+/NADH associated reactions under three carbon source conditions. Figure S1. Representative figure of gene expression level distribution under M9 glucose medium growth condition. Figure S2. Relative gene expression levels of reactions in the metabolic map of (A) Glycolysis (B) Pentose Phosphate Pathway of S. marcescens. (ZIP 898 kb)
DOI: 10.6084/m9.figshare.8088065.v1
title: Additional file 6 of GeneSurrounder: network-based identification of disease genes in expression data

description: Table of the full results of GeneSurrounder applied to GSE32894. (CSV 362 kb)
DOI: 10.6084/m9.figshare.8088068.v1
title: Additional file 2: of Metabolic characterization of the chitinolytic bacterium Serratia marcescens using a genome-scale metabolic model

description: Model file. (TXT 116 kb)
DOI: 10.6084/m9.figshare.8088053
title: Additional file 5 of GeneSurrounder: network-based identification of disease genes in expression data

description: Table of the full results of GeneSurrounder applied to GSE19915.GPL5186. (CSV 185 kb)
DOI: 10.6084/m9.figshare.8088056.v1
title: Additional file 1: of Metabolic characterization of the chitinolytic bacterium Serratia marcescens using a genome-scale metabolic model

description: Table S1. Average RPKM values of S. marcescens gene expression level at three different growth conditions. Table S2. Number of genes excluded/included after the lower/upper bound cutoff. Table S3. S.marcescens iSR929 reaction flux values after running Ruppin algorithm. Table S4. NAD+/NADH associated reactions under three carbon source conditions. Figure S1. Representative figure of gene expression level distribution under M9 glucose medium growth condition. Figure S2. Relative gene expression levels of reactions in the metabolic map of (A) Glycolysis (B) Pentose Phosphate Pathway of S. marcescens. (ZIP 898 kb)
DOI: 10.6084/m9.figshare.8088047
title: Additional file 4 of GeneSurrounder: network-based identification of disease genes in expression data

description: Table of the full results of GeneSurrounder applied to GSE13507. (CSV 463 kb)
DOI: 10.6084/m9.figshare.8088053.v1
title: Additional file 5 of GeneSurrounder: network-based identification of disease genes in expression data

description: Table of the full results of GeneSurrounder applied to GSE19915.GPL5186. (CSV 185 kb)
DOI: 10.6084/m9.figshare.8088038
title: Additional file 3 of GeneSurrounder: network-based identification of disease genes in expression data

description: Table of the full results of GeneSurrounder applied to GSE9891. (CSV 262 kb)
DOI: 10.6084/m9.figshare.8088047.v1
title: Additional file 4 of GeneSurrounder: network-based identification of disease genes in expression data

description: Table of the full results of GeneSurrounder applied to GSE13507. (CSV 463 kb)
DOI: 10.6084/m9.figshare.8088032
title: Additional file 2 of GeneSurrounder: network-based identification of disease genes in expression data

description: Table of the full results of GeneSurrounder applied to GSE17260. (CSV 259 kb)
DOI: 10.6084/m9.figshare.8088038.v1
title: Additional file 3 of GeneSurrounder: network-based identification of disease genes in expression data

description: Table of the full results of GeneSurrounder applied to GSE9891. (CSV 262 kb)
DOI: 10.6084/m9.figshare.8088029
title: Additional file 1 of GeneSurrounder: network-based identification of disease genes in expression data

description: Table of the full results of GeneSurrounder applied to GSE14764. (CSV 258 kb)
DOI: 10.6084/m9.figshare.8088032.v1
title: Additional file 2 of GeneSurrounder: network-based identification of disease genes in expression data

description: Table of the full results of GeneSurrounder applied to GSE17260. (CSV 259 kb)
DOI: 10.6084/m9.figshare.8088029.v1
title: Additional file 1 of GeneSurrounder: network-based identification of disease genes in expression data

description: Table of the full results of GeneSurrounder applied to GSE14764. (CSV 258 kb)
DOI: 10.6084/m9.figshare.8088008
title: Additional file 2: of Metabolic reprogramming involving glycolysis in the hibernating brown bear skeletal muscle

description: Table S2. List of vastus lateralis proteins identified in 2D gel spots, and exhibiting a differential abundance between hibernating (winter) and active (summer) brown bears (Ursus arctos). (XLSX 53â kb)
DOI: 10.6084/m9.figshare.8088008.v1
title: Additional file 2: of Metabolic reprogramming involving glycolysis in the hibernating brown bear skeletal muscle

description: Table S2. List of vastus lateralis proteins identified in 2D gel spots, and exhibiting a differential abundance between hibernating (winter) and active (summer) brown bears (Ursus arctos). (XLSX 53â kb)
DOI: 10.6084/m9.figshare.8088002
title: Additional file 1: of Metabolic reprogramming involving glycolysis in the hibernating brown bear skeletal muscle

description: Table S1. List of vastus lateralis proteins analysed in hibernating (winter) and active (summer) brown bears (Ursus arctos) using a MS-based strategy. (XLSX 4373â kb)
DOI: 10.6084/m9.figshare.8088002.v1
title: Additional file 1: of Metabolic reprogramming involving glycolysis in the hibernating brown bear skeletal muscle

description: Table S1. List of vastus lateralis proteins analysed in hibernating (winter) and active (summer) brown bears (Ursus arctos) using a MS-based strategy. (XLSX 4373â kb)
DOI: 10.6084/m9.figshare.8087948
title: Additional file 1: of Reliability testing of a modified MISTELS score using a low-cost trainer box

description: Results of the study containing the raw data used in the study. (XLSX 11 kb)
DOI: 10.6084/m9.figshare.8087948.v1
title: Additional file 1: of Reliability testing of a modified MISTELS score using a low-cost trainer box

description: Results of the study containing the raw data used in the study. (XLSX 11 kb)
DOI: 10.6084/m9.figshare.8087930
title: Additional file 3: of RNA sequencing of mesenchymal stem cells reveals a blocking of differentiation and immunomodulatory activities under inflammatory conditions in rheumatoid arthritis patients

description: Table S3. Number of reads successfully mapped and assigned to the metafeature “gene” per sample. (XLSX 3343 kb)
DOI: 10.6084/m9.figshare.8087930.v1
title: Additional file 3: of RNA sequencing of mesenchymal stem cells reveals a blocking of differentiation and immunomodulatory activities under inflammatory conditions in rheumatoid arthritis patients

description: Table S3. Number of reads successfully mapped and assigned to the metafeature “gene” per sample. (XLSX 3343 kb)
DOI: 10.6084/m9.figshare.8087840
title: Additional file 2: of Characterization of genomic DNA of lactic acid bacteria for activation of plasmacytoid dendritic cells

description: Table S2. 200 bp DNA fragments obtained from L. lactis LC-Plasma. (XLSX 13 kb)
DOI: 10.6084/m9.figshare.8087834
title: Additional file 1: of Haem iron reshapes colonic luminal environment: impact on mucosal homeostasis and microbiome through aldehyde formation

description: Experiment raw data and tables. (XLSX 167 kb)
DOI: 10.6084/m9.figshare.8087837
title: Additional file 1: of Characterization of genomic DNA of lactic acid bacteria for activation of plasmacytoid dendritic cells

description: Table S1. Primer sequences used for the amplification of CpG-rich or CpG-free fragments. Primer sequences and the number of copies of CpG motifs in the amplicon used for verifying involvement of CpG motifs. (XLSX 10 kb)
DOI: 10.6084/m9.figshare.8087840.v1
title: Additional file 2: of Characterization of genomic DNA of lactic acid bacteria for activation of plasmacytoid dendritic cells

description: Table S2. 200 bp DNA fragments obtained from L. lactis LC-Plasma. (XLSX 13 kb)
DOI: 10.6084/m9.figshare.8087825
title: Additional file 2: of Reported oral and anal sex among adolescents and adults reporting heterosexual sex in sub-Saharan Africa: a systematic review

description: Table S1. Selected data from quantitative studies reporting on heterosexual oral and anal sex in sub-Saharan Africa by year of publication. Table S2. Reported condom use during penetrative heterosexual sex (oral, anal and vaginal). Table S3. Risk of bias assessment for quantitative studies. Table S4. Risk of bias assessment of qualitative studies. (XLSX 41 kb)
DOI: 10.6084/m9.figshare.8087834.v1
title: Additional file 1: of Haem iron reshapes colonic luminal environment: impact on mucosal homeostasis and microbiome through aldehyde formation

description: Experiment raw data and tables. (XLSX 167 kb)
DOI: 10.6084/m9.figshare.8087837.v1
title: Additional file 1: of Characterization of genomic DNA of lactic acid bacteria for activation of plasmacytoid dendritic cells

description: Table S1. Primer sequences used for the amplification of CpG-rich or CpG-free fragments. Primer sequences and the number of copies of CpG motifs in the amplicon used for verifying involvement of CpG motifs. (XLSX 10 kb)
DOI: 10.6084/m9.figshare.8087825.v1
title: Additional file 2: of Reported oral and anal sex among adolescents and adults reporting heterosexual sex in sub-Saharan Africa: a systematic review

description: Table S1. Selected data from quantitative studies reporting on heterosexual oral and anal sex in sub-Saharan Africa by year of publication. Table S2. Reported condom use during penetrative heterosexual sex (oral, anal and vaginal). Table S3. Risk of bias assessment for quantitative studies. Table S4. Risk of bias assessment of qualitative studies. (XLSX 41 kb)
DOI: 10.6084/m9.figshare.8087789
title: MOESM4 of Silencing of a BAHD acyltransferase in sugarcane increases biomass digestibility

description: Additional file 4: Table S1. Spreadsheet containing quadratic model equations, in coded values, for 6 and 48 h enzymatic hydrolysis for events and NT plants.
DOI: 10.6084/m9.figshare.8087783
title: Additional file 1: of Development and characterisation of interspecific hybrid lines with genome-wide introgressions from Triticum timopheevii in a hexaploid wheat background

description: Physical positions on the A, B and D genomes of wheat of all markers present on the genetic maps of the At and G genomes of T. timopheevii, as obtained through BLAST against the wheat genome (RefSeq v1; [20]). Positions highlighted in yellow were the top hits in the BLAST search and markers highlighted in green represent a translocated region of the T. timopheevii chromosomes (XLSX 98 kb)
DOI: 10.6084/m9.figshare.8087789.v1
title: MOESM4 of Silencing of a BAHD acyltransferase in sugarcane increases biomass digestibility

description: Additional file 4: Table S1. Spreadsheet containing quadratic model equations, in coded values, for 6 and 48 h enzymatic hydrolysis for events and NT plants.
DOI: 10.6084/m9.figshare.8087774
title: Additional file 3: of Genetic mechanism underlying sexual plasticity and its association with colour patterning in zebrafish (Danio rerio)

description: Table S12. List of differentially expressed genes in male treatment fin vs. female treatment fin (MTF vs. FTF), which are used for gene set enrichment analysis (GSEA). Table S13. List of differentially expressed genes in male treatment gonad vs. female treatment gonad (MTG vs. FTG), which are used for gene set enrichment analysis (GSEA). Table S14. List of differentially expressed genes in overlapping between comparison groups, which are used for gene set enrichment analysis (GSEA). Table S15. Enriched pathways in male treatment fin vs. female treatment fin (MTF vs. FTF). Table S16. Enriched pathways in male treatment gonad vs. female treatment gonad (MTG vs. FTG). Table S17. Enriched pathways in overlapping between comparison groups . Table S18. Enriched GOs in male treatment fin vs. female treatment fin (MTF vs. FTF). Table S19. Enriched GOs in male treatment gonad vs. female treatment gonad (MTG vs. FTG). Table S20. Enriched GOs in overlapping between comparison groups. (XLSX 248â kb)
DOI: 10.6084/m9.figshare.8087774.v1
title: Additional file 3: of Genetic mechanism underlying sexual plasticity and its association with colour patterning in zebrafish (Danio rerio)

description: Table S12. List of differentially expressed genes in male treatment fin vs. female treatment fin (MTF vs. FTF), which are used for gene set enrichment analysis (GSEA). Table S13. List of differentially expressed genes in male treatment gonad vs. female treatment gonad (MTG vs. FTG), which are used for gene set enrichment analysis (GSEA). Table S14. List of differentially expressed genes in overlapping between comparison groups, which are used for gene set enrichment analysis (GSEA). Table S15. Enriched pathways in male treatment fin vs. female treatment fin (MTF vs. FTF). Table S16. Enriched pathways in male treatment gonad vs. female treatment gonad (MTG vs. FTG). Table S17. Enriched pathways in overlapping between comparison groups . Table S18. Enriched GOs in male treatment fin vs. female treatment fin (MTF vs. FTF). Table S19. Enriched GOs in male treatment gonad vs. female treatment gonad (MTG vs. FTG). Table S20. Enriched GOs in overlapping between comparison groups. (XLSX 248â kb)
DOI: 10.6084/m9.figshare.8087783.v1
title: Additional file 1: of Development and characterisation of interspecific hybrid lines with genome-wide introgressions from Triticum timopheevii in a hexaploid wheat background

description: Physical positions on the A, B and D genomes of wheat of all markers present on the genetic maps of the At and G genomes of T. timopheevii, as obtained through BLAST against the wheat genome (RefSeq v1; [20]). Positions highlighted in yellow were the top hits in the BLAST search and markers highlighted in green represent a translocated region of the T. timopheevii chromosomes (XLSX 98 kb)
DOI: 10.6084/m9.figshare.8087765
title: Additional file 2: of Genetic mechanism underlying sexual plasticity and its association with colour patterning in zebrafish (Danio rerio)

description: Table S9. Selected candidate sex determination genes used in this study. Table S10. Selected candidate colour patterning genes used in this study. Table S11. Quantile distribution of colour patterning genes in the caudal fin in the transcriptome profile (Log2CPM per mega base pairs). (XLSX 1847â kb)
DOI: 10.6084/m9.figshare.8087759
title: Additional file 1: of Genetic mechanism underlying sexual plasticity and its association with colour patterning in zebrafish (Danio rerio)

description: Table S1. Differentially expressed genes in male treatment gonad vs. male control gonad (MTG vs. MCG). Table S2. Differentially expressed genes in female treatment gonad vs. female control gonad (FTG vs. FCG). Table S3. Differentially expressed genes in male treatment fin vs. male control fin (MTF vs. MCF). Table S4. Differentially expressed genes in female treatment fin vs. female control fin (FTF vs. FCF). Table S5. Differentially expressed genes in male control gonad vs. female control gonad (MCG vs. FCG). Table S6. Differentially expressed genes in male treatment gonad vs. female treatment gonad (MTG vs. FTG). Table S7. Differentially expressed genes in male control fin vs. female control fin (MCF vs. FCF). Table S8. Differentially expressed genes in male treatment fin vs. female treatment fin (MTF vs. FTF). (XLSX 7713â kb)
DOI: 10.6084/m9.figshare.8087759.v1
title: Additional file 1: of Genetic mechanism underlying sexual plasticity and its association with colour patterning in zebrafish (Danio rerio)

description: Table S1. Differentially expressed genes in male treatment gonad vs. male control gonad (MTG vs. MCG). Table S2. Differentially expressed genes in female treatment gonad vs. female control gonad (FTG vs. FCG). Table S3. Differentially expressed genes in male treatment fin vs. male control fin (MTF vs. MCF). Table S4. Differentially expressed genes in female treatment fin vs. female control fin (FTF vs. FCF). Table S5. Differentially expressed genes in male control gonad vs. female control gonad (MCG vs. FCG). Table S6. Differentially expressed genes in male treatment gonad vs. female treatment gonad (MTG vs. FTG). Table S7. Differentially expressed genes in male control fin vs. female control fin (MCF vs. FCF). Table S8. Differentially expressed genes in male treatment fin vs. female treatment fin (MTF vs. FTF). (XLSX 7713â kb)