cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.15028707.v1
title: Supplementary Material for: A Dendritic Cells-Targeting Nano-Vaccine by Coupling Polylactic-Co-Glycolic Acid-Encapsulated Allergen with Mannan Induces Regulatory T Cells

description: <b><i>Background:</i></b> The efficacy of allergen-specific immunotherapy (AIT) is mainly depended on the tolerogenic immune responses elicited. Properly conjugated nano-vaccine has the advantages of both specific targeting and continuous and on-demand release of allergen. <b><i>Objectives:</i></b> The aim of this study is to investigate the effects of a dendritic cells (DCs)-targeting nano-vaccine for AIT. <b><i>Methods:</i></b> The nano-vaccine was produced by coupling polylactic-co-glycolic acid (PLGA)-encapsulated ovalbumin (OVA) with mannan. Allergen capture, human monocytes-derived DCs (hMoDCs) activation, and T cells responses were assessed by flow cytometry, confocal microscopy, quantitative real-time PCR, ELISA, and Cytometric Bead Array. Balb/c mice were immunized with the nano-vaccines, and the immune responses were analyzed. <b><i>Results:</i></b> OVA-PLGA nanoparticle (NP) displayed favorable safety profile. OVA-mannan-PLGA NP was captured more efficiently by hMoDCs than OVA-PLGA NP, which was mediated mainly through DC-specific intercellular adhesion molecule 3-grabbing nonintegrin. A tolerogenic phenotype of hMoDCs was induced by OVA-mannan-PLGA NP, but not OVA-PLGA NP, and increased number of regulatory T (Treg) cells was generated subsequently in in vitro coculture. Immunization of Balb/c mice with OVA-mannan-PLGA NP resulted in lower serum level of OVA-specific immunoglobulins and less production of pro-inflammatory cytokines in splenocytes culture than the mice immunized with OVA-PLAG NP, PLGA NP, or OVA, while the number of splenic Treg cells was higher in OVA-mannan-PLGA group than in other groups. Moreover, preimmunization with OVA-mannan-PLGA NP significantly inhibited the Th2 immune response induced by OVA sensitization. <b><i>Conclusions:</i></b> The biocompatible PLGA-encapsulated OVA coupling with mannan has augmented ability for tolerance induction and could be developed as a novel vaccine for AIT.
DOI: 10.6084/m9.figshare.23905560.v1
title: Files for manuscript 'Why am I overwhelmed by bright lights? The behavioural mechanisms of post-stroke visual hypersensitivity'

description: Dataset for manuscript 'Why am I overwhelmed by bright lights? The behavioural mechanisms of post-stroke visual hypersensitivity'
DOI: 10.6084/m9.figshare.26947462.v1
title: Yoga Movements with Comparative Study of two Strain Sensing Modalities

description: The participant is performing Yoga Poses (High Lunge, Lunge Forward, Squat, Tree) to compare the IDC and PP capacitive strain sensors integrated into the sports leggings on the left and right sides of the knee, respectively. The ΔC values are plotted against time, showing the differences between IDC and PP methods for each motion.
DOI: 10.6084/m9.figshare.5114059.v4
title: Quercus frainetto chorology

description: Distribution map of Hungarian oak (<i>Quercus frainetto</i>)<br><br>These maps were produced by combining numerous and heterogeneous data collected from atlas monographs providing complete species distribution maps, from national to regional atlases, occurrence geo-databases, scientific and grey literature.<br>The maps were created using ESRI shapefiles (*.shp, *.shx, *.dbf, *.prj files) archived in the ZIP file. Species range is mapped with polygon features (name suffix "plg"), which define continuous areas of occupancy of the species, and with point features (name suffix "pnt"), which identify more fragmented and isolated populations. If synanthropic occurrences are reported outside the species natural range, additional point and/or polygon shapefiles are also present (suffix "syn"). <br>Polygon borders delimiting species ranges are generalized across the mainland and sea boundaries. This offers the possibility to mask sea areas or to clip and extract the terrestrial range parts using GIS data layers of the users' choice. An additional version of polygon ranges are clipped with a coastline (name suffix "clip"), which have been derived from Natural Earth dataset "Admin 0 - Countries" 1:50M version 4.1.0 (https://www.naturalearthdata.com). <br><br>Please cite as:<br>Caudullo, G., Welk, E., San-Miguel-Ayanz, J., 2017. Chorological maps for the main European woody species. Data in Brief 12, 662-666. DOI: doi.org/10.1016/j.dib.2017.05.007 <br><br>Additional information and used references are on 'supplementary materials' document:<br>https://doi.org/10.6084/m9.figshare.5091901<br><br>Chorological maps are part of the "European Atlas of Forest Tree Species" project:<br>https://w3id.org/mtv/FISE-Comm/v01
DOI: 10.6084/m9.figshare.7330217.v1
title: Human Convalescent Serum Sample after DENV2 seroconversion.

description: Human Convalescent Serum Sample collected after DENV2 seroconversion.
DOI: 10.6084/m9.figshare.10718282.v11
title: Dataset for omicwas

description: The omicwas package implements ridge regression for cell-type-specific EWAS and differential gene expression. This dataset includes R notebooks and R data files for using omicwas.
DOI: 10.6084/m9.figshare.25322026.v1
title: gene_annotation_Leptobotia_longiformis

description: Prediction of gene structure of Leptobotia longiformis.
DOI: 10.6084/m9.figshare.12287027.v1
title: Supplementary Material for: Supratentorial Brain Metrics Predict Neurodevelopmental Outcome in Very Preterm Infants without Brain Injury at Age 2 Years

description: <b><i>Introduction:</i></b> Very preterm infants are at risk for adverse neurodevelopmental outcome. To better identify children without brain injury at risk for developmental sequelae, we assessed predictive values of supratentorial brain metrics in relation to outcome. <b><i>Methods:</i></b> Very preterm infants underwent magnetic resonance imaging (MRI) at term-equivalent age. Infants with any grade of supra- or infratentorial brain injury according to Kidokoro et al. [Pediatrics 2014;134:e444–53] were excluded. Supratentorial brain metrics (biparietal width, extracerebral space, interhemispheric distance) were measured and categorised using existing cut-off values. The Psychomotor Developmental Index (PDI) and Mental Developmental Index (MDI) were assessed using the Bayley Scales of Infant Development, second and third edition, at 2 years of age. Developmental delay was defined as a score &lt;85. Positive and negative predictive values for developmental delay were calculated. <b><i>Results:</i></b> A total of 237 very preterm infants were enrolled. Of all infants, 59 (21.2%) showed developmental delay. Infants with z-scores less than –0.5 for biparietal width had significantly lower PDI (<i>p</i> = 0.039) and MDI (<i>p</i> = 0.042) than infants with normal z-scores. Enlargement of extracerebral spaces was also related to lower PDI (<i>p</i> = 0.047) and MDI (<i>p</i> = 0.036). Negative predictive value was highest when all brain metrics were within the normal range (PDI &lt;85: 96.6%, MDI &lt;85: 90.0%). Combining the biparietal width and the interhemispheric distance showed highest positive predictive values for developmental delay (MDI or PDI &lt;85: 58.3%). <b><i>Discussion:</i></b> Supratentorial brain metrics are predictive for neurodevelopmental outcome in infants with ostensibly normal MRI. A combination of supratentorial brain metrics is most meaningful for identifying infants at risk for long-term sequelae.
DOI: 10.6084/m9.figshare.16910245.v1
title: Animal based disease outcome prediction

description: Animal based data and disease outcome at individual animal level
DOI: 10.6084/m9.figshare.28122170.v1
title: Acupressure PONV

description: <b>Efficacy of p6 acupressure band for prevention of postoperative nausea and vomiting in children: A randomized controlled trial</b><b>Abstract</b><b>Introduction</b>Postoperative nausea and vomiting in children remain a significant problem. Acupressure to P6 acupoint has been one of the effective strategies in the management of nausea and vomiting in the adult population. The aim of this study is to assess the effectiveness of P6 acupressure band in prevention of PONV in children.<b>Methods</b>This prospective randomized controlled trial recruited children who underwent elective surgery in a tertiary university hospital. Patients were randomised into 2 groups, Group 1 received acupressure band and group 2 received a standard elastic band 30 minutes prior to induction of anaesthesia. The acupressure band was worn with its embedded bead placed at P6 acupoint. All patients received standard care of anaesthesia. Occurrence of nausea and vomiting post-surgery were recorded hourly until 24 hours and band were removed after 24hours.<b>Results</b>Sixty four patients were recruited. Median Eberhart PONV risk score of 2 in both groups corresponded to a 20% risk of PONV. Duration of surgery and opioid requirement intraoperatively were comparable between the two groups. Both groups did not show a significant difference in occurrence of PONV and the requirement of rescue antiemetics postoperatively. Parental satisfaction on management of PONV in Group 1 and 2 were achieved at 89.4% and 94.2% respectively.<b>Conclusion</b>Acupressure band at p6 acupoint is not superior to placebo in management of PONV in children.
DOI: 10.6084/m9.figshare.14963034.v1
title: MAGIC_data

description: Data associated with a maize multiparent advanced generation intercross (MAGIC) population.Biogemma_600K_Genotypes_AGPv4_final_norm.vcf.gz contains genotypes of the MAGIC DH lines and the parental lines.BALANCE_NETWORK_IBARRA_FINAL-DELIVERY.csv contains data on the environments.BALANCE_NETWORK_IBARRA_RAWDATA_DELIVERY contains data on the phenotypes.<br>
DOI: 10.17632/xxn49crdk6
title: Factors influencing career choice of secondary school students in Nigeria

description: The persistent challenges in Science, Technology, Engineering, and Mathematics (STEM) fields stand as a significant barrier to realizing the United Nations' Sustainable Development Goals (SDGs), particularly those related to gender equality, quality education, and decent work. The aim of this project is to examine the depth and implications of gender imbalances within STEM through the eyes of secondary school students in Nigeria and uncover the multifaceted barriers with the aim of progressing the achievement of SDG5.
DOI: 10.6084/m9.figshare.19443503.v1
title: Sample data (five types of features of one participant)

description: Sample data (five types of features of one participant)
DOI: 10.15131/shef.data.3116833.v1
title: The homeService corpus v1.0

description: The <em>homeService</em> corpus is a new English database of realistic audio recorded from speakers with severe dysarthria which has been gathered as part of the Natural Speech Technology (NST) showcase, named homeService. The majority of the corpus is recorded in real home environments where voice control is often the normal means by which users interact with their devices.The <i>homeService corpus v1.0</i> is the first release of the audio recorded within the homeService project and it consists of audio recordings of dysarthric speech from 5 different subjects (three male, two female).<br> Each subject's set is composed by two subsets: enrolment data (ER) and interaction data (ID). A 16kHz mono audio resulting from the beam-formed combination of the 6 channels recorded with a microphone array is provided along with manual and automatic transcriptions.An agreement with University of Sheffield has to be signed to use the data.<strong>Audio cannot be redistributed under any circumstance</strong>.To <strong>download</strong> the homeService corpus please send a request to <em>homeservice-group@sheffield.ac.uk</em>
DOI: 10.17632/9tcm4wcdcr
title: Supplementary File 5: X-ray diffraction data for: The geometry, kinematics, and timing of deformation along the southern segment of the Paposo fault zone, Atacama fault system, northern Chile

description: X-ray diffraction data for illite.
DOI: 10.6084/m9.figshare.19958675.v1
title: Supplementary Material for: The Effect of Transurethral Resection of the Prostate on Erectile and Ejaculatory Functions in Patients with Benign Prostatic Hyperplasia

description: <b><i>Introduction:</i></b> The aim of this study was to investigate the effect of TURP on erectile function (EF) and ejaculatory function (EJF). <b><i>Methods:</i></b> A total of 91 patients who underwent TURP were retrospectively assessed. Patients were divided into two groups based on International Index of Erectile Function (IIEF-5): group A included 41 patients with normal EF, and group B included 50 patients with erectile dysfunction (ED). All patients were evaluated for EF and EJF at baseline, 1, 3, and 6 months after TURP by using IIEF-5, Ejaculatory Domain-Male Sexual-Health Inventory (Ej-MSHQ). <b><i>Results:</i></b> In group A, there were no significant statistical differences in mean IIEF-5 at baseline and after TURP 22.88 ± 0.81 versus 22.63 ± 2.63 (<i>p</i> = 0.065). However, in group B, there was significant improvement in IIEF-5 after TURP all over the follow-up time points in comparison to the baseline (<i>p</i> = &lt;0.001). The loss of EJF was significant among patients in group A. There was significant improvement of IPSS and Qmax in group A after surgery compared to group B. <b><i>Conclusion:</i></b> The results confirmed that TURP has no significant negative influence on EF, and patients with preexisting ED were improved after TURP. On the contrary, the loss of EJF was significant.
DOI: 10.6084/m9.figshare.20496558.v3
title: Field coefficients for the CHAOS-1969 model in the .mat format

description: Field coefficients for the CHAOS-1969 model in the .mat format derived for the article "Localized origin at the core-mantle boundary of the 1969 geomagnetic impulse".
<br>
Please refer to the project "Localized origin at the core-mantle boundary of the 1969 geomagnetic impulse" for further description (link in REFERENCES).
<br>
Changes in version 2:
- Uploaded README file
- .mat file contains coefficients for all fields
DOI: 10.17632/28bzh7bv68
title: Data for: Modulation of macrophages by bioactive glass/sodium alginate hydrogel is crucial in skin regeneration enhancement
DOI: 10.6084/m9.figshare.156599.v2
title: OACoder Software

description: Geodemographic classifications are small area classifications of social, economic and demographic characteristics. The Output Area Classification (OAC) is a free geodemographic classification. It is an ONS (Office of National Statistics) validated measure that summarises neighbourhood conditions at the Output Area Level across the United Kingdom. Linkage of this valuable statistics has been problematic for users more used to address records that are georeferenced using unit postcodes. ONS has recently made available an open licence version of the NSPD (National Statistics Postcode Directory), which usefully includes an OAC Code for each unit postcode in the UK. OACoder allows the users to read a CSV file containing a list of postcodes, uses the NSPD to append the corresponding OAC code for each of the postcoded addresses, and writes the resultant records to a CSV file. This software is made available under a GPL-3.0 license, and is described in the following paper: Muhammad, A. 2013. OACoder: Postcode Coding Tool. Journal of Open Research Software, 1(1) DOI: http://dx.doi.org/10.5334/511ba2c94d661
DOI: 10.6084/m9.figshare.24720087.v1
title: The mapping relationship between GHE cause categories and MeSH terms

description: The Global Health Estimates (GHE) cause category, structured hierarchically into four levels according to the International Classification of Diseases, 10th edition (ICD-10) and established by the World Health Organization (WHO), is available at https://cdn.who.int/media/docs/default-source/gho-documents/global-health-estimates/ghe2019_cod_methods.pdf?sfvrsn=37bcfacc_5. The mapping between Medical Subject Headings (MeSH) and GHE cause categories is established by associating diseases with relevant MeSH terms and incorporating all subordinate terms for each MeSH term, following the MeSH tree hierarchy. To prevent oversights and ensure accuracy, a manual double-check with human efforts is employed, verifying that disease-relevant MeSH terms are appropriately categorized, and subordinate terms are not assigned to multiple disease categories simultaneously.
DOI: 10.6084/m9.figshare.19606945.v1
title: Phosphorus addition decreases plant lignin but increases microbial necromass contribution to soil organic carbon in a subalpine forest

description: Soil microbial communities, plant and microbial biomarkers, as well as SOC physical and chemical fractions in a subalpine forest under P addition. <br>
DOI: 10.6084/m9.figshare.21206858.v1
title: Additional file 4 of A global phylogenomic and metabolic reconstruction of the large intestine bacterial community of domesticated cattle

description: Additional file 4: Table S4. Overview and characteristics of the 2114 MAGs, the 74 Hungate and the 102 RefSeq genomes used to reconstruct phylogenies in our study. From left to right: the internal code (a derivative of the accession number the data came from and the autometa id); the alternative name, which we either generated by identifying the closest match following BLAST comparisons with RefSeq or the assigned strain name (for reference genomes downloaded from databases); the accession number the MAG came from (when relevant); country where the sample was collected; author; dRep clustering and checkm (estimated completeness and contamination) and mean contig coverage (estimated by mapping filtered reads to contigs using Bowtie2). The overall mean and median are presented as well. The MAGs with the same drep clustering id are &gt;99% identical. The last column indicates the 1232 MAGs that were selected for the dereplicated dataset. The sequences of the 2114 MAGs are available here: doi.org/10.15454/UIJTJA . B: Mapping of filtered reads to contigs and the core MAGs. From left to right: Sample names, the total number of reads for each sample and the number of reads successfully mapped to contigs, the percentage of the number of reads mapped to contigs, the number of reads mapped to MAGs, and the percentage of reads mapped to MAGs. The smaller subtable to the right presents: the average percentage of reads successful mapping to contigs and to MAGs (top); the average percentage of reads mapped only to bacterial contigs (based on the classification from Autometa; NR database); the percentage of bacterial reads (based on the bacterial contig estimate) mapped to MAGs.
DOI: 10.6084/m9.figshare.5126449.v1
title: Supplementary Material for: <b><i>Toxoplasma gondii-</i></b>Derived Profilin Triggers Human Toll-Like Receptor 5-Dependent Cytokine Production

description: Up to a third of the world's population is infected with <i>Toxoplasma gondii.</i> Natural infection in humans can be life threatening during pregnancy and in immunocompromised individuals. Toll-like receptor (TLR) 11 is the mouse innate sensor that recognizes <i>T. gondii</i> profilin; however, in humans the <i>TLR11</i> gene leads to transcription of no functional protein. Herein, by using a multiple sequence alignment phylogenetic analysis program between human and mouse species, we found that human <i>TLR5</i> seems to be the evolutionarily closest member of the TLR gene family to mouse <i>tlr11</i>. We therefore asked whether human TLR5 could mediate IL-6, IL-8 and IL-12p70 production in response to the <i>T. gondii</i> profilin. We found that this was the case both in human cell lines as well as peripheral blood monocytes. Moreover, TLR5 neutralization and gene silencing mediated specific ablation of cytokine production after profilin exposure. Finally, peripheral blood monocytes carrying the TLR5 R392X mutation failed to produce cytokines in response to stimulation with profilin. Taken together, the results presented herein reveal a previously unappreciated cross-recognition of a relevant human pathogen-derived pathogen-associated molecular pattern.
DOI: 10.6084/m9.figshare.12783347.v1
title: Similar rates of fat oxidation during graded submaximal exercise in women of different body composition

description: Background. Despite the specific challenges pregnancy, menopause and contraception imposes on women’s cardiovascular health, no study has currently evaluated substrate oxidation of women differing in body composition at various exercise intensities recommended for weight loss.Methods. A total of 35 healthy women (age 30.8±9.5 yr) classified according to their BMI in normal weight (NOR; ≤24.9 kg·m<sup>2</sup>), overweight (OVW; 25-29.9 kg·m<sup>2</sup>) and obese groups (OBE; ≥30 kg·m<sup>2</sup>) completed a submaximal graded test (intensities eliciting ~30%, 40%, 50% and 60% of maximum oxygen uptake). Blood lactate, perceived exertion and absolute and relative substrate oxidation for fat (OX<sub>FAT</sub>) and carbohydrates (OX<sub>CHO</sub>) were measured at each stage.Results. Perceived exertion and blood lactate increased as a function of exercise but did not differ across groups. There were no significant changes in absolute and relative OX<sub>FAT</sub> across groups, or as a function of exercise intensity. Peak OX<sub>FAT</sub> occurred at the 40%, 50% and 40% stages for NOR, OVW and OBE groups, respectively, with no significant differences across groups.Discussion. We measured no differences, but considerable inter-individual variation, in fat oxidation in women of different body composition. This result is in agreement with previous research based on exercise performed at constant rate and in independent participant groups. Exercise prescription should emphasize individualizing testing responses for efficient weight management.
DOI: 10.6084/m9.figshare.27902628.v2
title: The Role of Flower Consumption in Female Howler Monkeys: Adjusting Diet across Reproductive Stages

description: Description per column:Year: year of the studyMonth: months of the studyDate: time-frame of the samplingN/L, L: lactation state of the female separated in non-lactating or lactatingN/L, LL, EL: lactation state of the female separated in non-lactating, late lactating and early lactatingAnimal.ID: the name assigned to each individualSubtype: kind of food source separated in leaf (LF), fruit (FR) and flower (FL)[g]/min: grams of the food source consumed within a minuteTN[g]/min: tannins in grams consummed per minute time[min]: time of the general group feeding sessiontime*TN: tannins consumed during a group feeding session
DOI: 10.17632/4wrnxhxxjf
title: A Cortico-basal ganglia-thalamo-cortical Channel Underlying Short-term Memory

description: In this research, we studied the function of cortico-basal ganglia-thalamo-cortical circuit during mice performing a delayed response task. Combined with optogenetics and electrophysiological recordings, we revealed the specific contributions of this circuit during maintaining of short-term memory. 
Here, we provide:
1. Single units, recorded in behavior mice with different optogenetics manipulations, and related behavior data. 
2. MATLAB codes for data analysis.