cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.19923254.v1
title: Salivary nitrite and systemic biomarkers in obese individuals with periodontitis submitted to FMD

description: Abstract The objective of this 9-month clinical study is to assess the impact of one-stage full-mouth disinfection (FMD) on salivary nitrite levels and systemic biomarkers and its correlation with total subgingival bacterial load in obese and non-obese patients with periodontitis. In total, 94 patients (55 obese and 39 non-obese) were initially evaluated, seven were lost during follow-up, resulting in 87 individuals at the end of the study. Outcomes were assessed at baseline, 3, 6, and 9 months post periodontal treatment by FMD. Salivary nitrite levels were determined using Griess reagent. Blood samples were collected to determine C-Reactive Protein (CRP), alkaline phosphatase and fasting blood glucose. Real-time PCR was used to determine the total subgingival bacterial load. FMD protocol resulted in increased salivary nitrite levels at 6- and 9-months post-treatment in the non-obese group (p&lt;0.05). In obese individuals, FMD treatment led to an increase in salivary nitrite levels at 6 months (p&lt;0.05); however, at 9 months, the nitrite levels returned to baseline levels. For both groups, the highest nitrite values were observed at 6 months. In addition, in both groups, FMD was associated with a decrease in biomarkers related to systemic inflammation and cardiovascular diseases, such as CRP (p&lt;0.05) and alkaline phosphatase (p&lt;0.05), and had no impact on the fasting blood glucose. This study demonstrates that obese patients with periodontitis present similar salivary nitrite levels when compared with non-obese individuals. FMD protocol resulted in increases in salivary nitrite levels and was associated with a positive impact on systemic biomarkers, regardless of obesity status.
DOI: 10.5281/zenodo.6343458
title: NIOO-QingZ/Geertruidenberg_Mesocosms: Towards climate-robust water quality management: testing the efficacy of different eutrophication control measures during a heat

description: Data and Codes used in the following open-access publication: https://www.sciencedirect.com/science/article/pii/S0048969722015145
DOI: 10.6084/m9.figshare.19923261
title: Additional file 3 of Optimal surveillance of intraductal papillary mucinous neoplasms of the pancreas focusing on remnant pancreas recurrence after surgical resection

description: Additional file 3: Supplementary Table. Clinicopathological characteristics of patients diagnosed as IPMC (n = 30).
DOI: 10.6084/m9.figshare.19923261.v1
title: Additional file 3 of Optimal surveillance of intraductal papillary mucinous neoplasms of the pancreas focusing on remnant pancreas recurrence after surgical resection

description: Additional file 3: Supplementary Table. Clinicopathological characteristics of patients diagnosed as IPMC (n = 30).
DOI: 10.6084/m9.figshare.19923285
title: Molecular Docking Studies of Curcumin Analogues against SARS-CoV-2 Spike Protein

description: Severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) is the etiologic agent of the current pandemic of coronavirus disease 2019 (COVID-19) that has inflicted the loss of thousands of lives worldwide. The coronavirus surface spike (S) glycoprotein is a class I fusion with a S1 domain which is attached to the human angiotensin converting enzyme 2 (ACE2) receptor, and a S2 domain which enables fusion with the host cell membrane and internalization of the virus. Curcumin has been suggested as a potential drug to control inflammation and as a potential inhibitor of S protein, but its therapeutic effects are hampered by poor bioavailability. We performed a molecular docking and dynamic study using 94 curcumin analogues designed to have improved metabolic stability against the SARS-CoV-2 spike protein and compared their affinity with curcumin and other potential inhibitors. The docking analysis suggested that the S2 domain is the main target of these compounds and compound 2606 displayed a higher binding affinity (-9.6 kcal mol-1) than curcumin (-6.8 kcal mol-1) and the Food and Drug Administration (FDA) approved drug hydroxychloroquine (-6.3 kcal mol-1). Further additional validation in vitro and in vivo of these compounds against SARS-CoV-2 may provide insights into the development of a drug that prevents virus entry into host cells.
DOI: 10.6084/m9.figshare.19923285.v1
title: Molecular Docking Studies of Curcumin Analogues against SARS-CoV-2 Spike Protein

description: Severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) is the etiologic agent of the current pandemic of coronavirus disease 2019 (COVID-19) that has inflicted the loss of thousands of lives worldwide. The coronavirus surface spike (S) glycoprotein is a class I fusion with a S1 domain which is attached to the human angiotensin converting enzyme 2 (ACE2) receptor, and a S2 domain which enables fusion with the host cell membrane and internalization of the virus. Curcumin has been suggested as a potential drug to control inflammation and as a potential inhibitor of S protein, but its therapeutic effects are hampered by poor bioavailability. We performed a molecular docking and dynamic study using 94 curcumin analogues designed to have improved metabolic stability against the SARS-CoV-2 spike protein and compared their affinity with curcumin and other potential inhibitors. The docking analysis suggested that the S2 domain is the main target of these compounds and compound 2606 displayed a higher binding affinity (-9.6 kcal mol-1) than curcumin (-6.8 kcal mol-1) and the Food and Drug Administration (FDA) approved drug hydroxychloroquine (-6.3 kcal mol-1). Further additional validation in vitro and in vivo of these compounds against SARS-CoV-2 may provide insights into the development of a drug that prevents virus entry into host cells.
DOI: 10.17632/dz47c9pnd5.1
title: DRC_POLITICIANS_DATASET

description: This dataset is a selection of old and recent images of senior politicians in the Democratic Republic of Congo. It is made up of 3431 images and 4113 face annotations of 19 politicians including 5 presidents of the republic, 1 vice president, 7 prime ministers, 1 governor, 2 presidents of the national assembly, a president of the senate and others. It contains more than 30% of very old black and white pictures for politicians who worked for independence in 1960.
It can be used for creating an archive of politicians , for computer vision and transfer learning purposes. It has got a best.pt pretained file for Yolov5
DOI: 10.6084/m9.figshare.19923287.v1
title: Primary cells derived from Tuberous Sclerosis Complex patients show autophagy alteration in the haploinsufficiency state

description: Abstract Tuberous sclerosis complex (TSC) is an autosomal dominant cancer predisposition disorder caused by heterozygous mutations in TSC1 or TSC2 genes and characterized by mTORC1 hyperactivation. TSC-associated tumors develop after loss of heterozygosity mutations and their treatment involves the use of mTORC1 inhibitors. We aimed to evaluate cellular processes regulated by mTORC1 in TSC cells with different mutations before tumor development. Flow cytometry analyses were performed to evaluate cell viability, cell cycle and autophagy in non-tumor primary TSC cells with different heterozygous mutations and in control cells without TSC mutations, before and after treatment with rapamycin (mTORC1 inhibitor). We did not observe differences in cell viability and cell cycle between the cell groups. However, autophagy was reduced in mutated cells. After rapamycin treatment, mutated cells showed a significant increase in the autophagy process (p=0.039). We did not observe differences between cells with distinct TSC mutations. Our main finding is the alteration of autophagy in non-tumor TSC cells. Previous studies in literature found autophagy alterations in tumor TSC cells or knock-out animal models. We showed that autophagy could be an important mechanism that leads to TSC tumor formation in the haploinsufficiency state. This result could guide future studies in this field.
DOI: 10.6084/m9.figshare.19923287
title: Primary cells derived from Tuberous Sclerosis Complex patients show autophagy alteration in the haploinsufficiency state

description: Abstract Tuberous sclerosis complex (TSC) is an autosomal dominant cancer predisposition disorder caused by heterozygous mutations in TSC1 or TSC2 genes and characterized by mTORC1 hyperactivation. TSC-associated tumors develop after loss of heterozygosity mutations and their treatment involves the use of mTORC1 inhibitors. We aimed to evaluate cellular processes regulated by mTORC1 in TSC cells with different mutations before tumor development. Flow cytometry analyses were performed to evaluate cell viability, cell cycle and autophagy in non-tumor primary TSC cells with different heterozygous mutations and in control cells without TSC mutations, before and after treatment with rapamycin (mTORC1 inhibitor). We did not observe differences in cell viability and cell cycle between the cell groups. However, autophagy was reduced in mutated cells. After rapamycin treatment, mutated cells showed a significant increase in the autophagy process (p=0.039). We did not observe differences between cells with distinct TSC mutations. Our main finding is the alteration of autophagy in non-tumor TSC cells. Previous studies in literature found autophagy alterations in tumor TSC cells or knock-out animal models. We showed that autophagy could be an important mechanism that leads to TSC tumor formation in the haploinsufficiency state. This result could guide future studies in this field.
DOI: 10.17632/g6cmkmms92.1
title: Supplement Figure I

description: Representative clinical pictures of multiple plantar warts cleared in two groups respectively.
Red circles shows target lesion，and blue arrows delineates non-target ones. Blue rectangle highlighted pictures in cryotherapy group showed a remote subungual wart under the patient's thumbnail.
DOI: 10.6084/m9.figshare.19923303
title: Charcoal-based dentifrices and powders: analyses of product labels, Instagram engagement, and altmetrics

description: Abstract This study identified charcoal-based dentifrices and abrasive powders sold in Brazil and analyzed their label information. The products were searched in four online shopping platforms. The same products were searched on Instagram and their engagement metrics were investigated. Furthermore, a literature review of international publications assessing charcoal dentifrices and powders was conducted, and altmetrics were collected (Altmetric and PlumX). Thirty-six products were found with prices between $0.4-22 USD. Most frequent words in product description were sodium, stain, whitening, oil, xylitol, and coconut. Only 3 products contained fluoride. Bactericidal, antiviral, antifungal, and anti-inflammatory activities were indicated, in addition to non-scientific claims such as calming teeth or increasing oral immunity. In total, 72% of products had Instagram profiles, which generally showed low engagement rates (81%) and medium audience quality scores (65%). Twenty-two articles were found in the literature, from which 21 were in vitro studies. The single clinical study was sponsored by a charcoal product and had no control group. In total, 23% of studies showed positive results and 55% reported negative results for the charcoal products, which included no whitening ability, increased roughness, surface alterations, and lower demineralization prevention ability. Altmetric scores for the included articles varied from 0 to 55, with 40.9% of studies mentioned online. In conclusion, charcoal-based products are using marketing strategies on Instagram but their current engagement with the public is not high. Consumers are being exposed to charcoal products whose potential risks to health are still unknown.
DOI: 10.6084/m9.figshare.19923303.v1
title: Charcoal-based dentifrices and powders: analyses of product labels, Instagram engagement, and altmetrics

description: Abstract This study identified charcoal-based dentifrices and abrasive powders sold in Brazil and analyzed their label information. The products were searched in four online shopping platforms. The same products were searched on Instagram and their engagement metrics were investigated. Furthermore, a literature review of international publications assessing charcoal dentifrices and powders was conducted, and altmetrics were collected (Altmetric and PlumX). Thirty-six products were found with prices between $0.4-22 USD. Most frequent words in product description were sodium, stain, whitening, oil, xylitol, and coconut. Only 3 products contained fluoride. Bactericidal, antiviral, antifungal, and anti-inflammatory activities were indicated, in addition to non-scientific claims such as calming teeth or increasing oral immunity. In total, 72% of products had Instagram profiles, which generally showed low engagement rates (81%) and medium audience quality scores (65%). Twenty-two articles were found in the literature, from which 21 were in vitro studies. The single clinical study was sponsored by a charcoal product and had no control group. In total, 23% of studies showed positive results and 55% reported negative results for the charcoal products, which included no whitening ability, increased roughness, surface alterations, and lower demineralization prevention ability. Altmetric scores for the included articles varied from 0 to 55, with 40.9% of studies mentioned online. In conclusion, charcoal-based products are using marketing strategies on Instagram but their current engagement with the public is not high. Consumers are being exposed to charcoal products whose potential risks to health are still unknown.
DOI: 10.6084/m9.figshare.19923320
title: Production cycle and characterization of Italian zucchini genotypes by the logistic model

description: ABSTRACT This study aimed to identify the productive cycle response of Italian zucchini genotypes grown under field conditions in two growing seasons using the nonlinear logistic model and its critical points. Two randomized block experiments were conducted, with three genotypes (Caserta, PX13067051, and Tronco) and two growing seasons (spring-summer and summer-fall), with eight replicates and each experimental unit consisting of 7 plants. The logistic nonlinear model was adjusted for the fruit mass variable, as a function of the accumulated thermal sum, and the critical points were estimated by the partial derivatives of the adjusted function. Adjustment by bootstrap resampling was performed to address the violation of assumptions. The results of intrinsic and parametric nonlinearity confirm the quality of the model fit. This experiment demonstrated that the zucchini genotypes evaluated were more productive in the spring-summer growing season, using the parameters and critical points obtained from the logistic nonlinear model. Genotypes PX13067051 and Caserta showed superior productivity to the Tronco genotype, and also fruited earlier and at a higher rate of production. The logistic growth model and its critical points characterized the production cycle of the zucchini genotypes in different growing seasons and allowed inferences to be made to differentiate the genotypes and the growing seasons.
DOI: 10.6084/m9.figshare.19923320.v1
title: Production cycle and characterization of Italian zucchini genotypes by the logistic model

description: ABSTRACT This study aimed to identify the productive cycle response of Italian zucchini genotypes grown under field conditions in two growing seasons using the nonlinear logistic model and its critical points. Two randomized block experiments were conducted, with three genotypes (Caserta, PX13067051, and Tronco) and two growing seasons (spring-summer and summer-fall), with eight replicates and each experimental unit consisting of 7 plants. The logistic nonlinear model was adjusted for the fruit mass variable, as a function of the accumulated thermal sum, and the critical points were estimated by the partial derivatives of the adjusted function. Adjustment by bootstrap resampling was performed to address the violation of assumptions. The results of intrinsic and parametric nonlinearity confirm the quality of the model fit. This experiment demonstrated that the zucchini genotypes evaluated were more productive in the spring-summer growing season, using the parameters and critical points obtained from the logistic nonlinear model. Genotypes PX13067051 and Caserta showed superior productivity to the Tronco genotype, and also fruited earlier and at a higher rate of production. The logistic growth model and its critical points characterized the production cycle of the zucchini genotypes in different growing seasons and allowed inferences to be made to differentiate the genotypes and the growing seasons.
DOI: 10.6084/m9.figshare.19923330
title: Do untreated caries influence the school leaving of adolescents? A cohort study

description: Abstract The objective was assess the influence of untreated caries and socioeconomic status (SES) on school dropout among adolescents. A six-year cohort study was conducted with random sample of adolescents (12 years-old) who had been evaluated initially in 2012 from Santa Maria, Brazil. Sex, socioeconomic status (mother’s education and household income), and untreated caries were collected at the baseline. The outcome variable was collected at the follow-up through self-report and was divided into three categories: adolescents who only studied, who studied and employed, and who school dropouts. A multinomial regression model was performed to assess the influence of oral disease and SES on school leaving, through relative risk ratio (RRR) and 95% confidence interval (95% CI). From of 1,134 adolescents evaluated at the baseline, 768 participants with a mean age of 17.5 years were re-evaluated at follow-up (67.8% response rate). Male (RRR: 2.31; 95%CI: 1.19-4.48) and adolescents with untreated caries at the baseline had an increment in school-leaving (RRR: 2.26; 95%CI: 1.12-4.56). Mothers with low education (RRR: 2.24; 95%CI: 1.09-4.61) had a higher probability of having children who leave school. Untreated caries and low SES in early adolescence can influence the tendency to school dropouts.
DOI: 10.6084/m9.figshare.19923330.v1
title: Do untreated caries influence the school leaving of adolescents? A cohort study

description: Abstract The objective was assess the influence of untreated caries and socioeconomic status (SES) on school dropout among adolescents. A six-year cohort study was conducted with random sample of adolescents (12 years-old) who had been evaluated initially in 2012 from Santa Maria, Brazil. Sex, socioeconomic status (mother’s education and household income), and untreated caries were collected at the baseline. The outcome variable was collected at the follow-up through self-report and was divided into three categories: adolescents who only studied, who studied and employed, and who school dropouts. A multinomial regression model was performed to assess the influence of oral disease and SES on school leaving, through relative risk ratio (RRR) and 95% confidence interval (95% CI). From of 1,134 adolescents evaluated at the baseline, 768 participants with a mean age of 17.5 years were re-evaluated at follow-up (67.8% response rate). Male (RRR: 2.31; 95%CI: 1.19-4.48) and adolescents with untreated caries at the baseline had an increment in school-leaving (RRR: 2.26; 95%CI: 1.12-4.56). Mothers with low education (RRR: 2.24; 95%CI: 1.09-4.61) had a higher probability of having children who leave school. Untreated caries and low SES in early adolescence can influence the tendency to school dropouts.
DOI: 10.6084/m9.figshare.19921772
title: Alien crustacean species recorded in Ecuador

description: Abstract Alien species are organisms introduced into an area outside of their natural range and are considered a major cause of biodiversity loss in the marine environment. The aim of this work is to report on the alien crustacean species observed in Ecuador. A bibliographic review was conducted using a digital search in the scientific literature. A total of ten alien species of crustaceans, representing eight genera in seven families, were encountered in Ecuador. The only crab, Cardisoma crassum Smith, 1870, was observed in the Galapagos Islands. The other species include barnacles, crayfishes, and freshwater prawns. Native ranges of the alien crustaceans include the Indo-Pacific region, North America, Asia, and Australia. Major introduction pathways are aquaculture and transport by ship. Procambarus alleni (Faxon, 1884) was reported recently as an aquarium species, but its presence in the natural environmental is currently unknown. One alien species has been introduced each decade since the 1960s. Some species (the barnacles Amphibalanus improvisus (Darwin, 1854), Amphibalanus reticulatus (Utinomi, 1967), and the copepod Lernaea cyprinacea Linnaeus, 1758) were reported as alien species for Ecuador but need verification regarding their current status. Additionally, the barnacle Dosima fascicularis (Ellis and Solander, 1786) presented an occasional record in the Galapagos Islands, but due to its dispersal ability and open ocean habitat it is not possible to conclude that this really is an alien species. The list of alien crustacean species recorded in Ecuador is considered incomplete due to both scarce published work regarding this topic and taxonomic problems. Therefore, it is necessary to carry out more research to establish a complete list of the alien species present in Ecuador and assess their impact on aquatic ecosystems.
DOI: 10.6084/m9.figshare.19921772.v1
title: Alien crustacean species recorded in Ecuador

description: Abstract Alien species are organisms introduced into an area outside of their natural range and are considered a major cause of biodiversity loss in the marine environment. The aim of this work is to report on the alien crustacean species observed in Ecuador. A bibliographic review was conducted using a digital search in the scientific literature. A total of ten alien species of crustaceans, representing eight genera in seven families, were encountered in Ecuador. The only crab, Cardisoma crassum Smith, 1870, was observed in the Galapagos Islands. The other species include barnacles, crayfishes, and freshwater prawns. Native ranges of the alien crustaceans include the Indo-Pacific region, North America, Asia, and Australia. Major introduction pathways are aquaculture and transport by ship. Procambarus alleni (Faxon, 1884) was reported recently as an aquarium species, but its presence in the natural environmental is currently unknown. One alien species has been introduced each decade since the 1960s. Some species (the barnacles Amphibalanus improvisus (Darwin, 1854), Amphibalanus reticulatus (Utinomi, 1967), and the copepod Lernaea cyprinacea Linnaeus, 1758) were reported as alien species for Ecuador but need verification regarding their current status. Additionally, the barnacle Dosima fascicularis (Ellis and Solander, 1786) presented an occasional record in the Galapagos Islands, but due to its dispersal ability and open ocean habitat it is not possible to conclude that this really is an alien species. The list of alien crustacean species recorded in Ecuador is considered incomplete due to both scarce published work regarding this topic and taxonomic problems. Therefore, it is necessary to carry out more research to establish a complete list of the alien species present in Ecuador and assess their impact on aquatic ecosystems.