cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.1603402
title: Effects of sulfated and non-sulfated <b>β</b>-glucan extracted from <i>Agaricus brasiliensis</i> in breast adenocarcinoma cells – MCF-7

description: The β-glucans (β-G) are polysaccharides produced by various organisms, and sulfation of β-G renders them more soluble. With the objective to assess the effects of sulfated and non-sulfated β-G extracted from <i>Agaricus brasiliensis</i> in MCF-7 cells, assays were used to evaluate cytotoxicity, genotoxicity, cell proliferation and mRNA expression. The sulfated and non-sulfated β-G showed dose-dependent cytotoxicity at concentrations of 5 and 10 μg/mL, by the MTT assay. However, only cytotoxicity was observed after 24 h by the Red Neutral test for sulfated β-G, with no genotoxicity for either β-G in comet assay. Proliferation was decreased only at 72 h at a concentration of 100 μg/mL of sulfated β-G. Treatment with 5 μg/mL of sulfated β-G for 6 h reduced the expression of pro-apoptotic genes and stress signaling genes, cell cycle arrest, damage and cell migration. The 5 μg/mL of non-sulfated β-G for 6 h reduced the expression of the stress response gene and signaling damage. These results indicate that the cytotoxicity in the MTT is not cell death, and that, in general, sulfated β-G have greater cytotoxicity compared to non-sulfated β-G.
DOI: 10.6084/m9.figshare.1603419.v2
title: General Defect Classification Usage Package

description: The General Defect Classification (GDC) allows to categorize software defects, warnings and changes in the code.
DOI: 10.6084/m9.figshare.1603402.v1
title: Effects of sulfated and non-sulfated <b>β</b>-glucan extracted from <i>Agaricus brasiliensis</i> in breast adenocarcinoma cells – MCF-7

description: The β-glucans (β-G) are polysaccharides produced by various organisms, and sulfation of β-G renders them more soluble. With the objective to assess the effects of sulfated and non-sulfated β-G extracted from <i>Agaricus brasiliensis</i> in MCF-7 cells, assays were used to evaluate cytotoxicity, genotoxicity, cell proliferation and mRNA expression. The sulfated and non-sulfated β-G showed dose-dependent cytotoxicity at concentrations of 5 and 10 μg/mL, by the MTT assay. However, only cytotoxicity was observed after 24 h by the Red Neutral test for sulfated β-G, with no genotoxicity for either β-G in comet assay. Proliferation was decreased only at 72 h at a concentration of 100 μg/mL of sulfated β-G. Treatment with 5 μg/mL of sulfated β-G for 6 h reduced the expression of pro-apoptotic genes and stress signaling genes, cell cycle arrest, damage and cell migration. The 5 μg/mL of non-sulfated β-G for 6 h reduced the expression of the stress response gene and signaling damage. These results indicate that the cytotoxicity in the MTT is not cell death, and that, in general, sulfated β-G have greater cytotoxicity compared to non-sulfated β-G.
DOI: 10.6084/m9.figshare.1603412.v2
title: Airport Mobile Website Evaluation in 2011

description: This set of data includes all data used for an article titled: Airport Mobile Website Evaluation: Terminal Navigation & Commercial Revenue. This is part of a PhD Thesis titled Airport Mobile Internet.
DOI: 10.6084/m9.figshare.1603400.v1
title: Gaussian Job Archive for C6H16O6

description: Archive of work produced using the resources of the Imperial College High Performance Computing Service.
DOI: 10.6084/m9.figshare.1603419.v3
title: General Defect Classification Usage Package

description: The General Defect Classification (GDC) allows to categorize software defects, warnings and changes in the code.
DOI: 10.6084/m9.figshare.1603322
title: Taxonomic status of <i>Cyanoramphus</i> parakeets on the Auckland Islands and implications for the validity of the orange-fronted parakeet as a discrete species

description: <i>Cyanoramphus</i> parakeets are a key biogeographic element of the Pacific. Many of these parakeets are, however, endangered, with ongoing conservation management hampered by the unresolved taxonomic status of some populations. We used modern and ancient DNA (mitochondrial DNA control region) to assess the taxonomy of the Auckland Islands populations of red-crowned (<i>Cyanoramphus novaezelandiae novaezelandiae</i>) and yellow-crowned (<i>Cyanoramphus auriceps</i>) parakeets. Our analyses show that both red-crowned and yellow-crowned parakeets on the Auckland Islands are nested within the mainland New Zealand diversity of the two species. However, we also found an orange-fronted parakeet (<i>Cyanoramphus malherbi</i>) mitochondrial DNA lineage within the genome of both of these species in the Auckland Islands population. Further sampling of historic orange-fronted parakeet museum skins showed that the orange-fronted morphotype is paraphyletic with respect to mitochondrial haplotype, which is probably caused by hybridisation or incomplete lineage sorting. In light of this, we review and critically assess the taxonomic history of the orange-fronted parakeet, and address whether the species was historically present on the Auckland Islands.
DOI: 10.6084/m9.figshare.1603322.v1
title: Taxonomic status of <i>Cyanoramphus</i> parakeets on the Auckland Islands and implications for the validity of the orange-fronted parakeet as a discrete species

description: <i>Cyanoramphus</i> parakeets are a key biogeographic element of the Pacific. Many of these parakeets are, however, endangered, with ongoing conservation management hampered by the unresolved taxonomic status of some populations. We used modern and ancient DNA (mitochondrial DNA control region) to assess the taxonomy of the Auckland Islands populations of red-crowned (<i>Cyanoramphus novaezelandiae novaezelandiae</i>) and yellow-crowned (<i>Cyanoramphus auriceps</i>) parakeets. Our analyses show that both red-crowned and yellow-crowned parakeets on the Auckland Islands are nested within the mainland New Zealand diversity of the two species. However, we also found an orange-fronted parakeet (<i>Cyanoramphus malherbi</i>) mitochondrial DNA lineage within the genome of both of these species in the Auckland Islands population. Further sampling of historic orange-fronted parakeet museum skins showed that the orange-fronted morphotype is paraphyletic with respect to mitochondrial haplotype, which is probably caused by hybridisation or incomplete lineage sorting. In light of this, we review and critically assess the taxonomic history of the orange-fronted parakeet, and address whether the species was historically present on the Auckland Islands.
DOI: 10.6084/m9.figshare.1603210
title: Shona Allophones

description: Shona allphones (The Shona alphabet)
DOI: 10.6084/m9.figshare.1603412.v3
title: Airport Mobile Website Evaluation: Terminal Navigation & Commercial Revenue

description: This set of data includes all data used for an article titled: Airport Mobile Website Evaluation: Terminal Navigation & Commercial Revenue. This is part of a PhD Thesis titled Airport Mobile Internet.
DOI: 10.6084/m9.figshare.1603208
title: Transcription Data

description: Data used to train the <strong>MaryTTS Transcription Tool</strong>
DOI: 10.6084/m9.figshare.1603412.v5
title: 1 - Airport Mobile Website Evaluation: Terminal Navigation & Commercial Revenue - DATASET

description: This set of data includes all data used for an article titled: Airport Mobile Website Evaluation: Terminal Navigation & Commercial Revenue. This is part of a PhD Thesis titled Airport Mobile Internet.
DOI: 10.6084/m9.figshare.1603419.v4
title: General Defect Classification Usage Package

description: The General Defect Classification (GDC) is a classification scheme that treats code 1) defects, 2) changes (“fixes of the defects”), 3) warnings from automated static analyzer tools (ASATs), and 4) the rules that generate these warnings (“checkers”) as first class citizens and allows their classification under one common topology.
DOI: 10.6084/m9.figshare.1603210.v1
title: Shona Allophones

description: Shona allphones (The Shona alphabet)
DOI: 10.6084/m9.figshare.1603419.v6
title: General Defect Classification Usage Package

description: The General Defect Classification (GDC) is a classification scheme that treats code 1) defects, 2) changes (“fixes of the defects”), 3) warnings from automated static analyzer tools (ASATs), and 4) the rules that generate these warnings (“checkers”) as first class citizens and allows their classification under one common topology.
DOI: 10.6084/m9.figshare.1603208.v1
title: Transcription Data

description: Data used to train the <strong>MaryTTS Transcription Tool</strong>
DOI: 10.6084/m9.figshare.1603412.v4
title: Airport Mobile Website Evaluation: Terminal Navigation & Commercial Revenue - DATASET

description: This set of data includes all data used for an article titled: Airport Mobile Website Evaluation: Terminal Navigation & Commercial Revenue. This is part of a PhD Thesis titled Airport Mobile Internet.
DOI: 10.6084/m9.figshare.1603174
title: Corpus WC3 from The LONI Pipeline

description: Multi-user corpus, containing all the submissions of workflows to the LONI Pipeline servers during the month of January, 2014. The datasets for the workflows have been removed.
DOI: 10.6084/m9.figshare.1603175
title: The LONI Pipeline workflow inputs

description: Corpora used to calculate commonly occurring workflow fragments from the LONI Pipeline
DOI: 10.6084/m9.figshare.1603419.v5
title: General Defect Classification Usage Package

description: The General Defect Classification (GDC) is a classification scheme that treats code 1) defects, 2) changes (“fixes of the defects”), 3) warnings from automated static analyzer tools (ASATs), and 4) the rules that generate these warnings (“checkers”) as first class citizens and allows their classification under one common topology.
DOI: 10.6084/m9.figshare.1603171
title: Corpus WC1 from the LONI Pipeline

description: Corpus WC1 used for extracting commonly occurring workflow fragments. The corpus has been created by one main user, often in collaboration with others. Datasets from the workflows are not included as part of the corpus, only the pipelines.
DOI: 10.6084/m9.figshare.1603175.v1
title: The LONI Pipeline workflow inputs

description: Corpora used to calculate commonly occurring workflow fragments from the LONI Pipeline
DOI: 10.6084/m9.figshare.1603170
title: Corpus WC2 from the LONI Pipeline

description: Corpus WC2 used for extracting commonly occurring workflow fragments. The corpus has been created by one main user, often in collaboration with others. Datasets from the workflows are not included as part of the corpus, only the pipelines.
DOI: 10.6084/m9.figshare.1603171.v1
title: Corpus WC1 from the LONI Pipeline

description: Corpus WC1 used for extracting commonly occurring workflow fragments. The corpus has been created by one main user, often in collaboration with others. Datasets from the workflows are not included as part of the corpus, only the pipelines.
DOI: 10.6084/m9.figshare.1603170.v1
title: Corpus WC2 from the LONI Pipeline

description: Corpus WC2 used for extracting commonly occurring workflow fragments. The corpus has been created by one main user, often in collaboration with others. Datasets from the workflows are not included as part of the corpus, only the pipelines.
DOI: 10.6084/m9.figshare.1603087
title: Gaussian Job Archive for C7H13NO5

description: Archive of work produced using the resources of the Imperial College High Performance Computing Service.
DOI: 10.6084/m9.figshare.1603087.v1
title: Gaussian Job Archive for C7H13NO5

description: Archive of work produced using the resources of the Imperial College High Performance Computing Service.
DOI: 10.6084/m9.figshare.1603088.v1
title: Gaussian Job Archive for C7H13F3O5

description: Archive of work produced using the resources of the Imperial College High Performance Computing Service.
DOI: 10.6084/m9.figshare.1603027
title: Validation study for GRINSQ

description: Validation study for GRINSQ conducted through Amazon Mechanical Turk with comparisons to Moral Judgment Test (MJT), Big Five (BFI-10), and Moral Foundations Questionaire (MFQ).
DOI: 10.6084/m9.figshare.1603026
title: General Recommended Feedback for Java programs of a computational programming exercise

description: This data set contains list of submitted Java programs based on series of online lab exercises from year 2013 to 2015. The programs were submitted by first year computer science students from Faculty of Informatics and Computing, Universiti Sultan Zainal Abidin, Malaysia who undertaking Introductory Computer Programming subject. There were 67, 18 and 47 of participated students in 2013, 2014 and 2015 respectively. The submitted programs were all of their solution attempts in answering a computational programming question. The question was as the following: <strong>Write a program that will read string. Then your program should show all the string character using * except for character 2, output its real character.</strong> <strong> sample input. </strong> <strong>Apology </strong> <strong>sample output. </strong> <strong>*p*****</strong>
DOI: 10.6084/m9.figshare.1603027.v1
title: Validation study for GRINSQ

description: Validation study for GRINSQ conducted through Amazon Mechanical Turk with comparisons to Moral Judgment Test (MJT), Big Five (BFI-10), and Moral Foundations Questionaire (MFQ).
DOI: 10.6084/m9.figshare.1603017
title: The polyunsaturated fatty acids arachidonic acid and docosahexaenoic acid induce mouse dendritic cells maturation but reduce T-cell responses in vitro

description: The polyunsaturated fatty acids arachidonic acid and docosahexaenoic acid induce mouse dendritic cells maturation but reduce T-cell responses in vitro
DOI: 10.6084/m9.figshare.1603018
title: The polyunsaturated fatty acids arachidonic acid and docosahexaenoic acid induce mouse dendritic cells maturation but reduce T-cell responses in vitro

description: The polyunsaturated fatty acids arachidonic acid and docosahexaenoic acid induce mouse dendritic cells maturation but reduce T-cell responses in vitro
DOI: 10.6084/m9.figshare.1603026.v2
title: General Recommended Feedback for Java programs of a computational programming exercise

description: This data set contains list of submitted Java programs based on series of online lab exercises from year 2013 to 2015. The programs were submitted by first year computer science students from Faculty of Informatics and Computing, Universiti Sultan Zainal Abidin, Malaysia who undertaking Introductory Computer Programming subject. There were 67, 18 and 47 of participated students in 2013, 2014 and 2015 respectively. The submitted programs were all of their solution attempts in answering a computational programming question. The question was as the following: <strong>Write a program that will read string. Then your program should show all the string character using * except for character 2, output its real character.</strong> <strong> sample input. </strong> <strong>Apology </strong> <strong>sample output. </strong> <strong>*p*****</strong>
DOI: 10.6084/m9.figshare.1603018.v1
title: The polyunsaturated fatty acids arachidonic acid and docosahexaenoic acid induce mouse dendritic cells maturation but reduce T-cell responses in vitro

description: The polyunsaturated fatty acids arachidonic acid and docosahexaenoic acid induce mouse dendritic cells maturation but reduce T-cell responses in vitro
DOI: 10.6084/m9.figshare.1603015
title: Tregs

description: Regulatory T cell subsets.
DOI: 10.6084/m9.figshare.1603016
title: Blocking experiment CD83 and PD-1

description: Co-culture of dendritic cells and T cells with or without blocking antibodies against CD83 or PD-1.
DOI: 10.6084/m9.figshare.1603026.v1
title: General Recommended Feedback for Java programs of a computational programming exercise

description: This data set contains list of submitted Java programs based on series of online lab exercises from year 2013 to 2015. The programs were submitted by first year computer science students from Faculty of Informatics and Computing, Universiti Sultan Zainal Abidin, Malaysia who undertaking Introductory Computer Programming subject. There were 67, 18 and 47 of participated students in 2013, 2014 and 2015 respectively. The submitted programs were all of their solution attempts in answering a computational programming question. The question was as the following: <strong>Write a program that will read string. Then your program should show all the string character using * except for character 2, output its real character.</strong> <strong> sample input. </strong> <strong>Apology </strong> <strong>sample output. </strong> <strong>*p*****</strong>
DOI: 10.6084/m9.figshare.1603014
title: Soluble mediators

description: Measurement of cytokines (IL-10, IL-12 p70, IFN-gamma, TGF-beta), soluble CD83 and Prostaglandin E2 (PGE2)
DOI: 10.6084/m9.figshare.1603015.v1
title: Tregs

description: Regulatory T cell subsets.
DOI: 10.6084/m9.figshare.1603017.v1
title: The polyunsaturated fatty acids arachidonic acid and docosahexaenoic acid induce mouse dendritic cells maturation but reduce T-cell responses in vitro

description: The polyunsaturated fatty acids arachidonic acid and docosahexaenoic acid induce mouse dendritic cells maturation but reduce T-cell responses in vitro
DOI: 10.6084/m9.figshare.1603023.v1
title: Collecting flies for genomic research: workflow at Smithsonian NMNH and Biorepository

description: Presentation given at Entomological Collectios Network meeting - Minneapolis, MN, USA - 14 Nov 2015
DOI: 10.6084/m9.figshare.1603013
title: Purity fatty acids

description: Gas chromatography analysis of fatty acid purity.
DOI: 10.6084/m9.figshare.1603016.v1
title: Blocking experiment CD83 and PD-1

description: Co-culture of dendritic cells and T cells with or without blocking antibodies against CD83 or PD-1.
DOI: 10.6084/m9.figshare.1602766
title: The Tm7sf2 Gene Deficiency Protects Mice against Endotoxin-Induced Acute Kidney Injury

description: Cholesterol is essential for diverse cellular functions and cellular and whole-body cholesterol<br>homeostasis is highly controlled. Cholesterol can also influence cellular susceptibility to injury.<br>The connection between cholesterol metabolism and inflammation is exemplified by the<br>Tm7sf2 gene, the absence of which reveals an essential role in cholesterol biosynthesis under<br>stress conditions but also results in an inflammatory phenotype, i.e. NF-κB activation and<br>TNFα up-regulation. Here, by using Tm7sf2+/+and Tm7sf2−/− mice, we investigated whether<br>the Tm7sf2 gene, through its role in cholesterol biosynthesis under stress conditions, is<br>involved in the renal failure induced by the administration of LPS. We found that the loss of<br>Tm7sf2 gene results in significantly reduced blood urea nitrogen levels accompanied by<br>decreased renal inflammatory response and neutral lipid accumulation. The increased expression<br>of fatty acids catabolic enzymes reduces the need of the renal autophagy, a known crucial<br>nutrient-sensing pathway in lipid metabolism. Moreover, we observed that the Tm7sf2 insufficiency<br>is responsible for the inhibition of the NF-κB signalling thus dampening the inflammatory<br>response and leading to a reduced renal damage. These results suggest a pivotal role for<br>Tm7sf2 in renal inflammatory and lipotoxic response under endotoxemic conditions.
DOI: 10.6084/m9.figshare.1602775
title: Gaussian Job Archive for C6H13F5O5S

description: Archive of work produced using the resources of the Imperial College High Performance Computing Service.
DOI: 10.6084/m9.figshare.1603013.v1
title: Purity fatty acids

description: Gas chromatography analysis of fatty acid purity.
DOI: 10.6084/m9.figshare.1602765
title: The Tm7sf2 Gene Deficiency Protects Mice against Endotoxin-Induced Acute Kidney Injury

description: INTRODUCTION: <em>Tm7sf2</em> gene codifies for 3β-hydroxysterol Δ14-reductase, an endoplasmic reticulum resident protein involved in cholesterol biosynthesis (1, 2). Cholesterol is an essential component of plasma membranes, and it can also contribute to multiple cellular functions or to injury response. Connection between cholesterol metabolism and inflammation is exemplified by <em>Tm7sf2</em>-KO mice, that under stress conditions show an inflammatory phenotype (NF-kB activation and TNFα upregulation) (3). In mouse skin, the loss of <em>Tm7sf2</em> gene reduces cholesterol/cholesterol sulfate levels following inflammatory insults, and increases susceptibility to skin papillomas formation (4). AIM OF THE STUDY: Investigation of the role of <em>Tm7sf2</em> gene in renal cholesterol/lipid metabolism and inflammatory response, in an in vivo model of acute kidney injury induced by the administration of lipopolysaccharide (LPS). MATERIALS AND METHODS: Male C57BL/6, <em>Tm7sf2+/+</em>, and<em> Tm7sf2-/-</em> mice were intraperitoneally injected with a single dose of LPS (5mg/Kg) or vehicle (0.9% saline) and sacrificed at selected time points. - Blood urea nitrogen (BUN) and serum creatinine assessment - Hematoxylin/eosin (HE), Oil Red O (ORO) stain, and immunohistochemistry on kidney sections - Renal cortex lipid content (TLC); mRNA and protein analysis by qPCR or Western blotting, respectively RESULTS: <em>Tm7sf2</em>-null mice are protected against LPS-induced acute kidney injury without affecting kidney cholesterol levels. <em>Tm7sf2</em> insufficiency reduces renal LPS-triggered NF-κB activation and iNOS expression <em>Tm7sf2</em> deficiency reduces neutral lipids accumulation in kidney The lack of <em>Tm7sf2</em> gene leads to FXR activation CONCLUSIONS: - The lack of <em>Tm7sf2</em> gene results in kidney endotoxin tolerance state contributing to dampen the inflammatory response generated by LPS exposure, i.e. NF-kB activation/iNOS expression - Lower ectopic accumulation of triglycerides (TG) in KO kidney could reduce the lipotoxicity due to secondary metabolites generation - We hypotesize that increased FXR activation in Tm7sf2-/- kidney antagonizes NF-kB/iNOS proinflammatory pathway and TG biogenesis process
DOI: 10.6084/m9.figshare.1602775.v1
title: Gaussian Job Archive for C6H13F5O5S

description: Archive of work produced using the resources of the Imperial College High Performance Computing Service.
DOI: 10.6084/m9.figshare.1603017.v2
title: The polyunsaturated fatty acids arachidonic acid and docosahexaenoic acid induce mouse dendritic cells maturation but reduce T-cell responses in vitro

description: The polyunsaturated fatty acids arachidonic acid and docosahexaenoic acid induce mouse dendritic cells maturation but reduce T-cell responses in vitro
DOI: 10.6084/m9.figshare.1602766.v1
title: The Tm7sf2 Gene Deficiency Protects Mice against Endotoxin-Induced Acute Kidney Injury

description: Cholesterol is essential for diverse cellular functions and cellular and whole-body cholesterol<br>homeostasis is highly controlled. Cholesterol can also influence cellular susceptibility to injury.<br>The connection between cholesterol metabolism and inflammation is exemplified by the<br>Tm7sf2 gene, the absence of which reveals an essential role in cholesterol biosynthesis under<br>stress conditions but also results in an inflammatory phenotype, i.e. NF-κB activation and<br>TNFα up-regulation. Here, by using Tm7sf2+/+and Tm7sf2−/− mice, we investigated whether<br>the Tm7sf2 gene, through its role in cholesterol biosynthesis under stress conditions, is<br>involved in the renal failure induced by the administration of LPS. We found that the loss of<br>Tm7sf2 gene results in significantly reduced blood urea nitrogen levels accompanied by<br>decreased renal inflammatory response and neutral lipid accumulation. The increased expression<br>of fatty acids catabolic enzymes reduces the need of the renal autophagy, a known crucial<br>nutrient-sensing pathway in lipid metabolism. Moreover, we observed that the Tm7sf2 insufficiency<br>is responsible for the inhibition of the NF-κB signalling thus dampening the inflammatory<br>response and leading to a reduced renal damage. These results suggest a pivotal role for<br>Tm7sf2 in renal inflammatory and lipotoxic response under endotoxemic conditions.