DOI: 10.5061/dryad.rv15dv4g6
title: Data from: Genetic susceptibility, Mendelian randomization and nomogram model construction of gestational diabetes mellitus

description: The dataset contains subjects’ basic information, including the
 Identification number of the test sample, fasting plasma glucose (FPG),
 oral glucose tolerance test 1h plasma glucose (1hPG), oral glucose
 tolerance test 2h plasma glucose (2hPG), glycated hemoglobin (HbA1c),
 Systolic blood pressure (SBP), Diastolic blood pressure (DBP),
 triglyceride (TG), total cholesterol (TC), High-density lipoprotein
 cholesterol (HDL-c), Low-density lipoprotein cholesterol (LDL-c), and also
 involves subjects’ genetic variant information used for analysis of the
 association of functional polymorphisms and GDM. The variables including
 SBP_M, DBP_M, FPG_M, 1hPG_M, 2hPG_M, HbA1c_M, TG_M represent the mean
 value of SBP, DBP, FPG, 1hPG, 2hPG, HbA1c, TG, which are used for the
 stratification analysis. This study has obtained the support from the
 Ethics Committee of Guilin Medical University. All included subjects
 signed the informed consent.
description: # Genetic susceptibility, Mendelian randomization and nomogram
 model construction of gestational diabetes mellitus Row Data for the
 Association of Functional Polymorphisms and GDM 1. Sample ID:
 Identification number of test sample 2. Group: 1=GDM; 0=Control group 3.
 Variants and genotypes assignment (1)rs1859489 A&gt;G: 1=AA genotype; 2=AG
 genotype;3=GG genotype (2)rs1965211 C&gt;T: 1=CC genotype; 2=CT
 genotype;3=TT genotype (3)rs208634 T&gt;C: 1=TT genotype; 2=TC
 genotype;3=CC genotype (4) rs2240794 C&gt;T: 1=CC genotype; 2=CT
 genotype;3=TT genotype (5)rs3189926 A&gt;C: 1=AA genotype; 2=AC
 genotype;3=CC genotype (6)rs3760675 T&gt;C: 1=TT genotype; 2=TC
 genotype;3=CC genotype (7) rs42318 C&gt;T: 1=CC genotype; 2=CT
 genotype;3=TT genotype (8)rs6570136 A&gt;G: 1=AA genotype; 2=AG
 genotype;3=GG genotype (9)rs7755323 A&gt;G: 1=AA genotype; 2=AG
 genotype;3=GG genotype (10)rs7814359 A&gt;G: 1=AA genotype; 2=AG
 genotype;3=GG genotype (11)rs899972 G&gt;T: 1=GG genotype; 2=GT
 genotype;3=TT genotype (12)rs1965211 Dominant model(CT/TT vs. CC):
 1=CCgenotype; 4=CT/TT genotypes (13)rs3760675 Dominant model(TC/CC vs.TT):
 1=TT genotype; 4=TC/CC genotypes (14)rs7814359 Dominant model(AG/GG
 vs.AA): 1=AA genotype; 4=AG/GG genotypes (15)rs1965211 Recessive model(TT
 vs. CC/CT): 3=TT genotype; 5=CC/CT genotypes (16)rs3760675 Recessive
 model(CC vs. TT/TC): 3=CC genotype; 5=TT/TC genotypes (17)rs7814359
 Recessive model(GG vs. AA/AG): 3=GG genotype; 5=AA/AG genotypes 1.
 Variables for stratification analysis (1) SBP_M (Mean SBP:110.08
 mmHg,1="≤110.08"；2= “＞110.08” ); (2)DBP_M (Mean DBP:69.53
 mmHg,1="≤69.53"；2= “＞69.53” ); (3)FPG_M (Mean FPG:4.79
 mmol/L,1="≤4.79"；2= “＞4.79” ); (4)1hPG_M (Mean OGTT 1h:8.26
 mmol/L,1="≤8.26"；2= “＞8.26”); (5)2hPG_M (Mean OGTT 2h:7.11
 mmol/L,1="≤7.11"；2= “＞7.11” ); (6)HbA1c_M (Mean HbA1c(%):5.20
 mmol/L,1="≤5.20"；2= “＞5.20” ); (7) TG_M (Mean TG:2.54
 mmol/L,1="≤2.54"；2= “＞2.54”); 1. Abbreviations： (1) GDM:
 gestational diabetes mellitus; (2) FPG(mmol/L): fasting plasma glucose;
 (3) 1hPG(mmol/L): oral glucose tolerance test 1h plasma glucose (4)
 2hPG(mmol/L): oral glucose tolerance test 2h plasma glucose (5) HbA1c(%):
 glycated hemoglobin (6) SBP(mmHg): Systolic blood pressure; (7) DBP(mmHg):
 Diastolic blood pressure; (8) TG(mmol/L): triglyceride; (9) TC(mmol/L):
 total cholesterol; (10) HDL-c(mmol/L): high-density lipoprotein
 cholesterol; (11) LDL-c(mmol/L): low-density lipoprotein cholesterol. 1.
 NA: missing value Supplementary material for "Genetic Susceptibility,
 Mendelian randomization and Nomogram Model Construction of Gestational
 Diabetes Mellitus" 1. Supplemental Table 1. The primers sequence of
 functional variants using for PCR 2. Supplemental Table 2. Demographic and
 clinical characteristics in cases and controls(mean±sd) 3. Supplemental
 Table 3. Stratification analysis for associations of positive SNPs and GDM
 risk 4. Supplemental Table 4. Association analysis of functional SNPs with
 GDM risk 5. Supplemental Table 5. FPRP analysis for the significant
 association of rs1965211, rs3760675, rs7814359 and GDM risk 6.
 Abbreviation: (1)PCR: Polymerase Chain Reaction; (2)GDM: Gestational
 Diabetes Mellitus; (3)SNPs: Single nucleotide polymorphisms; (4)FPRP:
 False-positive reporting probability.