cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.5634364
title: Adiponectin promoter polymorphisms are predictors of lipid profile improvement after bariatric surgery

description: Abstract Our aim was to investigate if single nucleotide polymorphisms (SNPs) located in the 5′ regions of leptin (LEP, -2548 G &gt; A, rs7799039), resistin (RETN, -420 C &gt; G, rs1862513) and adiponectin (ADIPOQ, -11391 G &gt; A, rs17300539 and -11377 C &gt; G, rs266729) genes were related to changes in body mass index (BMI) and metabolic variables after bariatric surgery in 60 extremely obese individuals. At baseline, ADIPOQ -11391 A-allele carriers showed higher plasma adiponectin and lower total cholesterol levels when compared to G/G homozygotes. Approximately 32 months post-surgery, a mean reduction of 35% in BMI and an important improvement in metabolic profiles were observed. In addition, for the ADIPOQ -11377 polymorphism, a higher decrease in lipid profile was associated to the C/C genotype. Moreover, individuals bearing the A-C haplotype for the two ADIPOQ SNPs were more prone to show a reduction in low-density lipoprotein levels after bariatric surgery (-43.0% A-C carriers vs. -18.1% G-G carriers, p = 0.019). We did not find any association of leptin and resistin SNPs with the clinical parameters analyzed. In summary, our results indicate that the A-C haplotype is a predictor of better lipid profile post-surgery and the studied SNPs in ADIPOQ gene are associated to changes in metabolic variables in obese individuals.
DOI: 10.6084/m9.figshare.5634364.v1
title: Adiponectin promoter polymorphisms are predictors of lipid profile improvement after bariatric surgery

description: Abstract Our aim was to investigate if single nucleotide polymorphisms (SNPs) located in the 5′ regions of leptin (LEP, -2548 G &gt; A, rs7799039), resistin (RETN, -420 C &gt; G, rs1862513) and adiponectin (ADIPOQ, -11391 G &gt; A, rs17300539 and -11377 C &gt; G, rs266729) genes were related to changes in body mass index (BMI) and metabolic variables after bariatric surgery in 60 extremely obese individuals. At baseline, ADIPOQ -11391 A-allele carriers showed higher plasma adiponectin and lower total cholesterol levels when compared to G/G homozygotes. Approximately 32 months post-surgery, a mean reduction of 35% in BMI and an important improvement in metabolic profiles were observed. In addition, for the ADIPOQ -11377 polymorphism, a higher decrease in lipid profile was associated to the C/C genotype. Moreover, individuals bearing the A-C haplotype for the two ADIPOQ SNPs were more prone to show a reduction in low-density lipoprotein levels after bariatric surgery (-43.0% A-C carriers vs. -18.1% G-G carriers, p = 0.019). We did not find any association of leptin and resistin SNPs with the clinical parameters analyzed. In summary, our results indicate that the A-C haplotype is a predictor of better lipid profile post-surgery and the studied SNPs in ADIPOQ gene are associated to changes in metabolic variables in obese individuals.
DOI: 10.6084/m9.figshare.5634352
title: Results from portable and of low cost equipment developed for detection of milk adulterations

description: Abstract This work presents the results of a device, MilkTech, developed to detect milk tampering, based on electrical measurements. The device indicates possible frauds by water, sodium chloride, caustic soda, ethyl alcohol and sodium bicarbonate. The advantages in relation to traditional methods are portability, low cost and detection of mixed frauds. The experiments were conducted in dairy plants at Governador Valadares, in Brazil. The results were compared with cryoscopy and chloride tests. It is demonstrated there is high correlation between MilkTech and Cryoscopy. For instance, the detection limit of the equipment for water addition with the set of analyzed data was 0.78% with precision of 1.1%. Adulterations with sodium chloride, caustic soda, ethyl alcohol and sodium bicarbonate are detected qualitatively, even when added with water, and MilkTech indicates “SUSPECT” milk.
DOI: 10.6084/m9.figshare.5634352.v1
title: Results from portable and of low cost equipment developed for detection of milk adulterations

description: Abstract This work presents the results of a device, MilkTech, developed to detect milk tampering, based on electrical measurements. The device indicates possible frauds by water, sodium chloride, caustic soda, ethyl alcohol and sodium bicarbonate. The advantages in relation to traditional methods are portability, low cost and detection of mixed frauds. The experiments were conducted in dairy plants at Governador Valadares, in Brazil. The results were compared with cryoscopy and chloride tests. It is demonstrated there is high correlation between MilkTech and Cryoscopy. For instance, the detection limit of the equipment for water addition with the set of analyzed data was 0.78% with precision of 1.1%. Adulterations with sodium chloride, caustic soda, ethyl alcohol and sodium bicarbonate are detected qualitatively, even when added with water, and MilkTech indicates “SUSPECT” milk.
DOI: 10.6084/m9.figshare.5634346
title: The stratified win ratio

description: The win ratio was first proposed in 2012 by Pocock and his colleagues to analyze a composite endpoint while considering the clinical importance order and the relative timing of its components. It has attracted considerable attention since then, in applications as well as methodology. It is not uncommon that some clinical trials require a stratified analysis. In this article, we propose a stratified win ratio statistic in a similar way as the Mantel-Haenszel stratified odds ratio, derive a general form of its variance estimator with a plug-in of existing or potentially new variance/covariance estimators of the number of wins for the two treatment groups, and assess its statistical performance using simulation studies. Our simulations show that our proposed Mantel-Haenszel-type stratified win ratio performs similarly to the Mantel-Haenszel stratified odds ratio for the simplified situation when the win ratio reduces to the odds ratio, and our proposed stratified win ratio is preferred compared to the inverse-variance weighted win ratio and unweighted win ratio particularly when the data are sparse. We also formulate a homogeneity test following Cochran’s approach that assesses whether the stratum-specific win ratios are homogeneous across strata, as this method is used frequently in meta-analyses and a better test for the win ratio homogeneity is not available yet.
DOI: 10.6084/m9.figshare.5634346.v1
title: The stratified win ratio

description: The win ratio was first proposed in 2012 by Pocock and his colleagues to analyze a composite endpoint while considering the clinical importance order and the relative timing of its components. It has attracted considerable attention since then, in applications as well as methodology. It is not uncommon that some clinical trials require a stratified analysis. In this article, we propose a stratified win ratio statistic in a similar way as the Mantel-Haenszel stratified odds ratio, derive a general form of its variance estimator with a plug-in of existing or potentially new variance/covariance estimators of the number of wins for the two treatment groups, and assess its statistical performance using simulation studies. Our simulations show that our proposed Mantel-Haenszel-type stratified win ratio performs similarly to the Mantel-Haenszel stratified odds ratio for the simplified situation when the win ratio reduces to the odds ratio, and our proposed stratified win ratio is preferred compared to the inverse-variance weighted win ratio and unweighted win ratio particularly when the data are sparse. We also formulate a homogeneity test following Cochran’s approach that assesses whether the stratum-specific win ratios are homogeneous across strata, as this method is used frequently in meta-analyses and a better test for the win ratio homogeneity is not available yet.
DOI: 10.6084/m9.figshare.5634250.v1
title: Keyhole: Equal signs as bridges between the phenomenological and theoretical dimensions

description: Physics is a peculiar way to reason about the world that often makes the invisible visible. If one aims at understanding what physics is about, recognise how experimental measurements and mathematical reasoning are intertwined is essential. In this work we exemplify such entanglement by analysing three case studies. In the first one, the explanation of the Hall effect underlines how we indirectly penetrate into the microscopic structure of a wire and manage to evaluate the number of charged particles per unit volume inside it from a set of macroscopic measurements. The second case shows how our reasoning allows us to determine the radius of a hydrogen atom from the experimental measure of the atom's binding energy. The third example comes from kinetic gas theory and illustrates how it is possible to estimate the number of gas particles per unit volume from the experimental values of pressure and temperature. These three case studies show that the equal sign of certain equations can be seen as a bridge (keyhole) connecting the empirical and theoretical dimensions. We argue that epistemological reflections should be an essential part of science education if we aim at delivering an authentic picture of the nature of physics.
DOI: 10.6084/m9.figshare.5634226
title: 2015 PLoS ONE TBI-Ethanol Data.xlsx

description: data from PMID: 25910266
DOI: 10.6084/m9.figshare.5634208.v1
title: CT and XMT image data of diprotodont and artiodactyl limb bones to accompany Doube et al. 2018

description: CT and X-ray microtomography images of humerus, radius, ulna, metacarpal, femur, tibia and metatarsal bones from artiodactyl and diprotodont specimens.<br>
DOI: 10.6084/m9.figshare.5634208.v2
title: CT and XMT image data of macropod and artiodactyl limb bones to accompany Doube et al. 2018

description: CT and X-ray microtomography images of humerus, radius, ulna, metacarpal, femur, tibia and metatarsal bones from artiodactyl (Artiodactyla) and macropod (Diprotodontia, suborder Macropodiformes) specimens.<br>
DOI: 10.5281/zenodo.4009167
title: More precise tracking of horizontal than vertical target motion with both the eyes and hand

description: Those files contain individual data from a large cohort of participant (N=62). In the excel file (DATAmain), each sheet presents one set of variables (with individual value for each trial). This file contains information regarding eye and hand tracking performance (distance+lags), as well as smooth pursuit gains. The other files contain data that we used for the detailed analysis of saccades and lags, as well as the scripts that can be run with Perl. One script is for analysing the lag (Danion.pl) and the other one for analysing the saccades (saccades.pl). The other files (.txt and .dat) that were used for these analyses. Note that some library is needed (common_subroutines, draw_figure, and for the anova’s routines_that_use_R), meaning that you need to have R installed. <pre> </pre>
DOI: 10.6084/m9.figshare.5633983.v2
title: The interrelationships of land plants and the nature of the ancestral embryophyte.

description: Amino acid alignments, topologies, and gene trees from Puttick et al. 2018. The interrelationships of land plants and the nature of the ancestral embryophyte.
DOI: 10.6084/m9.figshare.5633983
title: The interrelationships of land plants and the nature of the ancestral embryophyte.

description: Amino acid alignments, topologies, and gene trees from Puttick et al. 2018. The interrelationships of land plants and the nature of the ancestral embryophyte.
DOI: 10.6084/m9.figshare.5633971

description: PLEASE ADD TO LIST
DOI: 10.6084/m9.figshare.5633962
title: raw data for igg suclass

description: raw data for establishing reference intervals of igg subclass in children<br>
DOI: 10.6084/m9.figshare.5633962.v1
title: raw data for igg suclass

description: raw data for establishing reference intervals of igg subclass in children<br>
DOI: 10.6084/m9.figshare.5633947
title: Grinding Wheel Surfaces from On modelling the interaction between two rotating bodies with statistically distributed features: an application to dressing of grinding wheels

description: Dressed Grinding Wheel Data from experiments and simulations for topography comparison.
DOI: 10.6084/m9.figshare.5633944
title: Dressing Forces from On modelling the interaction between two rotating bodies with statistically distributed features: an application to dressing of grinding wheels

description: Dressing Force Data from experiments and simulations for average values comparison.
DOI: 10.6084/m9.figshare.5633944.v1
title: Dressing Forces from On modelling the interaction between two rotating bodies with statistically distributed features: an application to dressing of grinding wheels

description: Dressing Force Data from experiments and simulations for average values comparison.
DOI: 10.6084/m9.figshare.5633938
title: Perrault_2017_Supplementary_Materials.zip from Tongues on the EDGE: language preservation priorities based on threat and lexical distinctiveness

description: Input data, phylogenies, R code, and full EDGE scores
DOI: 10.6084/m9.figshare.5633938.v1
title: Perrault_2017_Supplementary_Materials.zip from Tongues on the EDGE: language preservation priorities based on threat and lexical distinctiveness

description: Input data, phylogenies, R code, and full EDGE scores
DOI: 10.6084/m9.figshare.5633917
title: Supplementary materials and methods; Full data set from Effects of mutations in phage restriction sites during escape from restriction–modification

description: information on culture conditions, phage mutagenesis, verification and lysate preparation; Raw data
DOI: 10.6084/m9.figshare.5633917.v1
title: Supplementary materials and methods; Full data set from Effects of mutations in phage restriction sites during escape from restriction–modification

description: information on culture conditions, phage mutagenesis, verification and lysate preparation; Raw data
DOI: 10.6084/m9.figshare.5633902
title: Cryptic and non-cryptic diversity in New Guinea ground snakes of the genus <i>Stegonotus</i> Duméril, Bibron and Duméril, 1854: a description of four new species (Squamata: Colubridae)

description: The island of New Guinea has been identified as biologically megadiverse but many taxa are still poorly known. This is especially the case for many of the island’s snakes, which by their very nature can be difficult to collect and study. Here we examine the phylogenetic and phylogeographic structure of a poorly studied snake genus, <i>Stegonotus</i>, focusing on the species of New Guinea; until now, <i>Stegonotus</i> has never been examined using modern phylogenetic methods. Using molecular data from 49 individuals representing eight of the ten described species, and including all New Guinea taxa, we estimate a multilocus phylogeny and examine population structure to help identify undescribed taxa. We use morphological data from the corresponding museum vouchered specimens (where available) and also examine additional specimens for taxa not included in the molecular data set to determine morphological differences among putative taxa. We find molecular evidence for four new species of <i>Stegonotus</i>, both morphologically obvious and cryptic, and describe them herein. The recognition of these four species indicates that <i>Stegonotus</i> diversity has been previously underestimated and also suggests that there are likely additional undescribed taxa within the genus. These four taxa increase the number of described species by 40% and further confirm New Guinea as the centre of diversity for the genus. www.zoobank.org/urn:lsid:zoobank.org:pub:9E21390E-3FD4-40EB-9442-31BC92A76B4F
DOI: 10.6084/m9.figshare.5633902.v1
title: Cryptic and non-cryptic diversity in New Guinea ground snakes of the genus <i>Stegonotus</i> Duméril, Bibron and Duméril, 1854: a description of four new species (Squamata: Colubridae)

description: The island of New Guinea has been identified as biologically megadiverse but many taxa are still poorly known. This is especially the case for many of the island’s snakes, which by their very nature can be difficult to collect and study. Here we examine the phylogenetic and phylogeographic structure of a poorly studied snake genus, <i>Stegonotus</i>, focusing on the species of New Guinea; until now, <i>Stegonotus</i> has never been examined using modern phylogenetic methods. Using molecular data from 49 individuals representing eight of the ten described species, and including all New Guinea taxa, we estimate a multilocus phylogeny and examine population structure to help identify undescribed taxa. We use morphological data from the corresponding museum vouchered specimens (where available) and also examine additional specimens for taxa not included in the molecular data set to determine morphological differences among putative taxa. We find molecular evidence for four new species of <i>Stegonotus</i>, both morphologically obvious and cryptic, and describe them herein. The recognition of these four species indicates that <i>Stegonotus</i> diversity has been previously underestimated and also suggests that there are likely additional undescribed taxa within the genus. These four taxa increase the number of described species by 40% and further confirm New Guinea as the centre of diversity for the genus. www.zoobank.org/urn:lsid:zoobank.org:pub:9E21390E-3FD4-40EB-9442-31BC92A76B4F
DOI: 10.6084/m9.figshare.5633884
title: Fairness and Efficiency in Smallholder Farming: The Relation with Intrahousehold Decision-Making

description: Agricultural households face collective action dilemmas when making decisions about investments in their common household farm and the allocation of resources and benefits derived from it. We relate intrahousehold decisions, as measured in a lab-in-the-field experiment conducted with spouses in agricultural households in western Uganda, with actual investments and intrahousehold resource allocation. Intrahousehold decision-making that supports cooperation and equitable sharing is associated with greater investment in the intensification of cash and food crop production, and more equitable access and control over income. Freeriding behaviour by husbands is associated with the intensification of cash crop production, but not with equitable sharing.
DOI: 10.6084/m9.figshare.5633884.v1
title: Fairness and Efficiency in Smallholder Farming: The Relation with Intrahousehold Decision-Making

description: Agricultural households face collective action dilemmas when making decisions about investments in their common household farm and the allocation of resources and benefits derived from it. We relate intrahousehold decisions, as measured in a lab-in-the-field experiment conducted with spouses in agricultural households in western Uganda, with actual investments and intrahousehold resource allocation. Intrahousehold decision-making that supports cooperation and equitable sharing is associated with greater investment in the intensification of cash and food crop production, and more equitable access and control over income. Freeriding behaviour by husbands is associated with the intensification of cash crop production, but not with equitable sharing.
DOI: 10.6084/m9.figshare.12623768
title: MCMC_DivergenceTime_Analysis.zip

description: Outputs from the MCMCtree divergence time on the 200 slow evolving loci matrix. 1. “CMCtree.tre”: final tree in newick format; 2. "MCMCtree_effective_prior.tre”: tree output from run with no data; 3. “ CMCtree_analysis.txt”: output from the MCMCtree analysis; 4. “MCMCtree_analysis_effective_prior.txt”: output from the MCMCtree analysis run without data
DOI: 10.6084/m9.figshare.12623768.v1
title: MCMC_DivergenceTime_Analysis.zip

description: Outputs from the MCMCtree divergence time on the 200 slow evolving loci matrix. 1. “CMCtree.tre”: final tree in newick format; 2. "MCMCtree_effective_prior.tre”: tree output from run with no data; 3. “ CMCtree_analysis.txt”: output from the MCMCtree analysis; 4. “MCMCtree_analysis_effective_prior.txt”: output from the MCMCtree analysis run without data
DOI: 10.6084/m9.figshare.5633845.v1
title: Corinth Rift transient rivers characterize evolving crustal-scale elastic flexure

description: Crustal elastic flexure on the sides of rift-forming faults is a key feature to characterize continental rifting processes that has never been examined by means of transient river drainages on rift footwalls. The elastic flexure dynamics of the main shoulder of the fast-extending and asymmetric Corinth Rift (Greece) are recorded virtually in 3D in its fluvial geomorphology. We explore the evolution of the mechanical flexure of the lithosphere along rift full length by means of DEM-based river profile analysis of a series of footwall catchments orthogonal to rift master fault. We show that elastic footwall flexure prescribes the first-order geometry of longitudinal river profiles as a function of master fault onset time and/or slip rate. Flexure amplitude is maximum in the center of the rift, where drainage reversal of two catchments suggest very fast slip rates on the master fault, and decays (i) sharply to the east, where river profiles are near equilibrium with the modern displacement field, and (ii) gently to the west, where transient river profiles exhibit a morphology consistent with relatively lower rates of flexural uplift and abundant evidence for active drainage reorganization. Taken together, these observations are consistent with landscape respond to a time transgressive fault initiation and uplift history since a recent shift in tectonic boundary conditions, probably younger 620 ka. The singularity of drainage reversal by footwall flexure is an extreme setting that suggests a radical increase in master fault slip rate due to an abrupt tectonic change. Besides, the full-rift extent of flexure requires a steep fault growing in a strong lithosphere. This is at odds with Corinth Rift models based on fault migration basinward and shallow detachments and supports the hypothesis of rift evolution associated with the growth by propagation of the North Anatolian Fault.
DOI: 10.6084/m9.figshare.5633767
title: Supplementary Material for: Stress-Kinase Regulation of TASK-1 and TASK-3

description: <b><i>Background/Aims:</i></b> TASK channels belong to the two-pore-domain potassium (K<sub>2P</sub>) channel family. TASK-1 is discussed to contribute to chronic atrial fibrillation (AFib) and has been together with uncoupling protein 1 found as a marker protein of brown adipose tissue (BAT) fat. In addition, TASK-1 was linked in a genome-wide association study to an increased body mass index. A recent study showed that TASK-1 inhibition is causing obesity in mice by a BAT whitening and that these effects are linked to the mineralocorticoid receptor pathway, albeit the mechanism remained elusive. Therefore, we aimed to probe whether K<sub>2P</sub> channels are regulated by serum- and glucocorticoid-inducible kinases (SGKs) which are known to modify many cellular functions by modulating ion channels. <b><i>Methods:</i></b> To this end we used functional co-expression studies and chemiluminescence-assays in <i>Xenopus</i> oocytes, together with fluorescence imaging and quantitative PCR experiments. <b><i>Results:</i></b> SGKs and proteinkinase B (PKB) induced a strong, dose- and time-dependent current reduction of TASK-1 and TASK-3. SGK co-expression reduced the surface expression of TASK-1/3, leading to a predominant localization of the channels into late endosomes. The down regulation of TASK-3 channels was abrogated by the dynamin inhibitor dynasore, confirming a role of SGKs in TASK-1/3 channel endocytosis. <b><i>Conclusion:</i></b> Stress-mediated changes in SGK expression pattern or activation is likely to alter TASK-1/3 expression at the surface membrane. The observed TASK-1 regulation might contribute to the pathogenesis of chronic AFib and provide a mechanistic link between increased mineralocorticoid levels and TASK-1 reduction, both linked to BAT whitening.