cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.6860096.v4
title: Leipzig-Helmstedt data set

description: This data set contains historical merged data from Lipsiensium and Helmstedt.
DOI: 10.6084/m9.figshare.6860096.v3
title: Leipzig-Helmstedt data set

description: This data set contains historical merged data from Lipsiensium and Helmstedt.
DOI: 10.6084/m9.figshare.6860045
title: Supplementary Material for: Hyponatremia in Acute Heart Failure in Relation to Hematocrit Levels: Clinical Relevance and Prognostic Implication

description: <b><i>Background:</i></b> Hyponatremia is the most common electrolyte abnormality found in hospitalized patients with acute heart failure (AHF) and is related to poor prognosis. This study sought to evaluate: (1) the different prognostic impact of dilutional versus depletional hyponatremia, evaluating short- and long-term outcome; (2) the relationship between both types of hyponatremia and intravenous furosemide dose, renal function changes, and persistent congestion at discharge. <b><i>Methods:</i></b> This retrospective single-center study included 233 consecutive patients with a primary diagnosis of AHF. Hyponatremia was defined as serum sodium &lt; 135 mEq/L, which could be either dilutional (hematocrit &lt; 35%) or depletional (hematocrit ≥35%). Persistent congestion was defined as a congestion score ≥2 at discharge. Patients were followed 180 days for occurrence of death or rehospitalization for AHF. <b><i>Results:</i></b> Hyponatremia was present in 68/233 patients with 27 cases classified as dilutional hyponatremia versus 41 as depletional. The proportion of patients with persistent congestion was higher in the dilutional hyponatremia group, but similar in the depletional hyponatremia group (52 vs. 81 vs. 58%; <i>p</i> = 0.02). After adjustment for important baseline characteristics, dilutional hyponatremia was significantly associated with the risk of death or rehospitalization for AHF at 60 days (HR 2.17 [1.08–4.37]; <i>p</i> = 0.03) and 180 days (HR 1.88 [1.10–3.21]; <i>p</i> = 0.02). In contrast, depletional hyponatremia was only significantly associated with the same endpoint at 180 days (HR 1.64 [1.05–2.57]; <i>p</i> = 0.03). <b><i>Conclusions:</i></b> Low hematocrit levels in AHF patients with hyponatremia characterize a population that is more difficult to decongest and has poor clinical outcome. In contrast, patients with hyponatremia but normal hematocrit are better decongested and have better short-term outcome.
DOI: 10.6084/m9.figshare.6860045.v1
title: Supplementary Material for: Hyponatremia in Acute Heart Failure in Relation to Hematocrit Levels: Clinical Relevance and Prognostic Implication

description: <b><i>Background:</i></b> Hyponatremia is the most common electrolyte abnormality found in hospitalized patients with acute heart failure (AHF) and is related to poor prognosis. This study sought to evaluate: (1) the different prognostic impact of dilutional versus depletional hyponatremia, evaluating short- and long-term outcome; (2) the relationship between both types of hyponatremia and intravenous furosemide dose, renal function changes, and persistent congestion at discharge. <b><i>Methods:</i></b> This retrospective single-center study included 233 consecutive patients with a primary diagnosis of AHF. Hyponatremia was defined as serum sodium &lt; 135 mEq/L, which could be either dilutional (hematocrit &lt; 35%) or depletional (hematocrit ≥35%). Persistent congestion was defined as a congestion score ≥2 at discharge. Patients were followed 180 days for occurrence of death or rehospitalization for AHF. <b><i>Results:</i></b> Hyponatremia was present in 68/233 patients with 27 cases classified as dilutional hyponatremia versus 41 as depletional. The proportion of patients with persistent congestion was higher in the dilutional hyponatremia group, but similar in the depletional hyponatremia group (52 vs. 81 vs. 58%; <i>p</i> = 0.02). After adjustment for important baseline characteristics, dilutional hyponatremia was significantly associated with the risk of death or rehospitalization for AHF at 60 days (HR 2.17 [1.08–4.37]; <i>p</i> = 0.03) and 180 days (HR 1.88 [1.10–3.21]; <i>p</i> = 0.02). In contrast, depletional hyponatremia was only significantly associated with the same endpoint at 180 days (HR 1.64 [1.05–2.57]; <i>p</i> = 0.03). <b><i>Conclusions:</i></b> Low hematocrit levels in AHF patients with hyponatremia characterize a population that is more difficult to decongest and has poor clinical outcome. In contrast, patients with hyponatremia but normal hematocrit are better decongested and have better short-term outcome.
DOI: 10.6084/m9.figshare.6860009
title: Supplementary Material for: Significance of the Lysyl Oxidase Members Lysyl Oxidase Like 1, 3, and 4 in Gastric Cancer

description: <b><i>Background/Aims:</i></b> Lysyl oxidase (LOX) family members play a key role in modifying the primary tumor microenvironment by crosslinking collagens and elastin in the extracellular matrix. The aim of this study was to analyze the LOX-like (LOXL)1, LOXL3, and LOXL4 expressions in gastric cancer tissue by immunohistochemical staining. <b><i>Methods:</i></b> The correlations between the clinicopathological features of 597 primary gastric carcinomas and LOX family members – LOXL1, LOXL3, and LOXL4 – were investigated by immunohistochemical studies. The effect of the transforming growth ­factor β1 (TGFβ1) on the expressions of <i>LOXL1, LOXL3,</i> and <i>LOXL4</i> in gastric cancer was examined using diffuse-type gastric cancer cell lines in vitro. <b><i>Results:</i></b> The expressions of LOXL1, LOXL3, and LOXL4 were correlated with T invasion, lymph node metastasis, and lymphatic and venous invasion. LOXL1 expression was associated with histological intestinal-type and expanding growth patterns. The overall survival of patients with LOXL1-, LOXL3-, or LOXL4-positive cancer was poorer than those with negative cancer. <i>LOXL3</i> and <i>LOXL4</i> mRNA expressions were significantly high in diffuse-type gastric cancer cells with high invasion ability. TGFβ decreased the LOXL1 expression and increased LOXL3 and LOXL4 expression. <b><i>Conclusion:</i></b> LOXL1, LOXL3, and LOXL4 expressions are associated with distant metastasis of gastric cancer.
DOI: 10.6084/m9.figshare.6859937
title: Data

description: Exported fields and results.<br>
DOI: 10.6084/m9.figshare.6859937.v1
title: Data

description: Exported fields and results.<br>
DOI: 10.6084/m9.figshare.6859907
title: Vivamus.html

description: html
DOI: 10.6084/m9.figshare.6859907.v1
title: Untitled Item

description: html
DOI: 10.6084/m9.figshare.6859907.v2
title: Vivamus.html

description: html
DOI: 10.6084/m9.figshare.6859907.v4
title: Vivamus.html

description: html
DOI: 10.6084/m9.figshare.6859907.v3
title: Vivamus.html

description: html
DOI: 10.6084/m9.figshare.6859823
title: Supplementary Material for: Renal Sympathetic Denervation in Patients with Resistant Hypertension: A Feasibility Study

description: <b><i>Background/Aims:</i></b> We assessed the feasibility of renal sympathetic denervation (RDN) treatment in patients with resistant hypertension using the Iberis® RDN system. This study was a prospective, multicenter, single-arm feasibility registry. <b><i>Methods:</i></b> We collected data from patients who underwent RDN treatment using the Iberis system. From November 2014 to February 2016, 16 patients from 6 centers in Europe were enrolled in this registry. <b><i>Results:</i></b> Consistent reductions in the 24-h systolic blood pressure (SBP) and diastolic blood pressure were obtained. At any follow-up point, more than 70% of the patients were responders. The change in the 24-h SBP at 1 month was strongly correlated with that at 12 months. <b><i>Conclusion:</i></b> The Iberis system is safe and effective in patients for the treatment of resistant hypertension. Furthermore, our results suggest that we can estimate the effect of RDN in the long term at the 1-month follow-up point using the 24-h SBP.
DOI: 10.6084/m9.figshare.6859808
title: Supplementary Material for: Surgical Cystotomy of a Large Iris Pigment Epithelial Cyst with Microinstrumentation

description: <b><i>Purpose:</i></b> Surgical intervention is indicated for large primary iris pigment epithelial cysts that significantly affect vision or compromise adjacent structures. Methods described in the literature include laser photocoagulation, needle aspiration, and complete resection. <b><i>Methods:</i></b> We describe a novel surgical technique in which a surgical cystotomy is created for a large, symptomatic iris pigment epithelial cyst using microsurgical instruments for a patient in whom needle aspiration was unsuccessful. <b><i>Results:</i></b> The patient’s visual symptoms had largely resolved within 1 week postoperatively, no complications were encountered, and there was no clinical or sonographic evidence of cyst recurrence after 14 months. <b><i>Conclusion:</i></b> Surgical cystotomy with microinstrumentation may be an effective tool for management of primary iris pigment epithelial cysts, especially as an alternative after needle aspiration fails.
DOI: 10.6084/m9.figshare.6859784
title: Supplementary Material for: Restating the Case for a Sharp Population Decline in <b><i>Lemur catta</i></b>

description: As with many other species in the primate order, ring-tailed lemurs <i>(Lemur catta)</i> are threatened with extinction. Our articles documented declines in wild ring-tailed lemur populations and noted that fewer than 2,500 wild ring-tailed lemurs are known to persist in 32 [Gould and Sauther: <i>Primate Conservation</i> 2016; 30: 89–101] and 34 [LaFleur et al.: <i>Folia Primatologica</i> 2017; 87: 320–330] sites. A criticism of our articles [Murphy et al.: <i>International Journal of Primatology</i> 2017; 38: 623–628] suggested that we have inadequately sampled ring-tailed lemur populations and habitats, and misused the literature. We disagree, and provide both a detailed rebuttal and responses to specific critique points herein. Moreover, we restate our case outlining a dramatic decline of ring-tailed lemurs resulting from anthropogenic pressures (deforestation, severe habitat fragmentation, extraction for the pet and bushmeat trades). We pose several thought-provoking questions as to when is the appropriate time for researchers to “sound the alarm” about a species’ decline, and remain committed to understanding the drivers of unsustainable exploitation of this emblematic lemur, and preventing their extinction in the wild.
DOI: 10.6084/m9.figshare.6859781
title: Supplementary Material for: Selective and Context-Dependent Social and Behavioral Effects of Δ<sup>9</sup>-Tetrahydrocannabinol in Weakly Electric Fish

description: Cannabinoid (CB) receptors are widespread in the nervous system and influence a variety of behaviors. Weakly electric fish have been a useful model system in the study of the neural basis of behavior, but we know nothing of the role played by the CB system. Here, we determine the overall behavioral effect of a nonselective CB receptor agonist, namely Δ<sup>9</sup>-tetrahydrocannabinol (THC), in the weakly electric fish <i>Apte­ronotus leptorhynchus.</i> Using various behavioral paradigms involving social stimuli, we show that THC decreases locomotor behavior, as in many species, and influences communication and social behavior. Across the different experiments, we found that the propensity to emit communication signals (chirps) and seek social interactions was affected in a context-dependent manner. We explicitly tested this hypothesis by comparing the behavioral effects of THC injection in fish placed in a novel versus a familiar social and physical environment. THC-injected fish were less likely to chirp than control fish in familiar situations but not in novel ones. The tendency to be in close proximity to other fish was affected only in novel environments, with control fish clustering more than THC-injected ones. By identifying behaviors affected by CB agonists, our study can guide further comparative and neurophysiological studies of the role of the CB system using a weakly electric fish as a model.
DOI: 10.6084/m9.figshare.6859715
title: Supplementary Material for: Gastroesophageal Reflux Disease-Related Disorders of Systemic Sclerosis Based on the Analysis of 66 Patients

description: <b><i>Background/Aims:</i></b> Gastroesophageal reflux disease (GERD)-related disorders of systemic sclerosis (SSc) patients have not been adequately investigated. <b><i>Methods:</i></b> Sixty-six SSc patients (5 males and 61 females; 56.6 ± 14.6 years old) who underwent esophagogastroduodenoscopy were analyzed on the basis of 16 background factors. They were additionally compared with 116 matched non-SSc subjects controlling age, sex, and use of proton pump inhibitors (PPIs). <b><i>Results:</i></b> The mean disease duration of 66 patients was 5.1 ± 8.1 years, and their breakdown was as follows: 53 (80.3%) with GERD, 38 (57.6%) with GERD-related symptoms, and 20 (30.3%) with reflux esophagitis (RE; LA-A: 10, LA-B: 5, LA-C: 4, LA-D: 1). Use of PPI (<i>p</i> = 0.0455), complication of interstitial lung disease (<i>p</i> = 0.0242), and history of cyclophosphamide therapy (<i>p</i> = 0.0184) denoted significant association with GERD-related symptoms. Older age (<i>p</i> = 0.0211) was significantly associated with RE. None of GERD-related disorders showed any difference between 37 diffuse cutaneous SSc and 29 limited cutaneous SSc patients. The matched analysis indicated that SSc patients had higher prevalence of GERD (<i>p </i>&lt; 0.0001), GERD-related symptoms (<i>p</i> = 0.0034), and RE (<i>p </i>= 0.0002). <b><i>Conclusion:</i></b> SSc patients tend to have worse GERD symptoms and severer RE. However, most SSc-associated factors did not show significant association with GERD-related disorders, indicating the difficulty in predicting GERD-related disorders among SSc patients.
DOI: 10.6084/m9.figshare.6859664
title: MIGRATION AND THE PROBLEM OF IDENTITY IN KHALED HOSSEINI’S AND THE MOUNTAINS ECHOED: REQUESTIONING THE CULTURE’S ROOT

description: This article discusses the recent novel from Khaled Hosseini which entitled "<i>And the Mountains Echoed</i>" through the perspective of Postcolonialism specifically in the analysis of Identity and Being by Stuart Hall.
DOI: 10.6084/m9.figshare.6859595
title: Statistics

description: Statistics on GTAA and Wikidata
DOI: 10.6084/m9.figshare.6859595.v1
title: Statistics

description: Statistics on GTAA and Wikidata
DOI: 10.6084/m9.figshare.6859124
title: Additional file 1: of Sucrose metabolism in developing oil-rich tubers of Cyperus esculentus: comparative transcriptome analysis

description: Table S1. Summary of C. esculentus transcriptome datasets, assembly and annotation, and number of transcripts and unigenes related to carbohydrate metabolism. Table S2. Annotation of C. esculentus transcriptome. Table S3. Annotation and expression levels for selected genes associated with sucrose metabolism. Table S4. Primer pairs used for qRT-PCR. Table S5. The assembled sequences for selected genes associated with sucrose metabolism. (XLSX 6684 kb)
DOI: 10.6084/m9.figshare.6859124.v1
title: Additional file 1: of Sucrose metabolism in developing oil-rich tubers of Cyperus esculentus: comparative transcriptome analysis

description: Table S1. Summary of C. esculentus transcriptome datasets, assembly and annotation, and number of transcripts and unigenes related to carbohydrate metabolism. Table S2. Annotation of C. esculentus transcriptome. Table S3. Annotation and expression levels for selected genes associated with sucrose metabolism. Table S4. Primer pairs used for qRT-PCR. Table S5. The assembled sequences for selected genes associated with sucrose metabolism. (XLSX 6684 kb)
DOI: 10.6084/m9.figshare.6859064
title: MOESM6 of DNA metabarcoding reveals the complex and hidden responses of chironomids to multiple stressors

description: Additional file 6. Sequencing reads assigned to other taxonomic groups.
DOI: 10.6084/m9.figshare.6859064.v1
title: MOESM6 of DNA metabarcoding reveals the complex and hidden responses of chironomids to multiple stressors

description: Additional file 6. Sequencing reads assigned to other taxonomic groups.
DOI: 10.6084/m9.figshare.6859052
title: MOESM5 of DNA metabarcoding reveals the complex and hidden responses of chironomids to multiple stressors

description: Additional file 5. Taxonomic assignment of the 35 most common chironomid OTUs.
DOI: 10.6084/m9.figshare.6859052.v1
title: MOESM5 of DNA metabarcoding reveals the complex and hidden responses of chironomids to multiple stressors

description: Additional file 5. Taxonomic assignment of the 35 most common chironomid OTUs.
DOI: 10.6084/m9.figshare.6859037
title: MOESM4 of DNA metabarcoding reveals the complex and hidden responses of chironomids to multiple stressors

description: Additional file 4. Read abundances and standardization of read numbers.
DOI: 10.6084/m9.figshare.6859037.v1
title: MOESM4 of DNA metabarcoding reveals the complex and hidden responses of chironomids to multiple stressors

description: Additional file 4. Read abundances and standardization of read numbers.
DOI: 10.6084/m9.figshare.6859022
title: MOESM3 of DNA metabarcoding reveals the complex and hidden responses of chironomids to multiple stressors

description: Additional file 3. Publically available chironomid COI sequences from specimens sampled in Germany from BOLD(downloaded 01.06.2017).
DOI: 10.6084/m9.figshare.6859022.v1
title: MOESM3 of DNA metabarcoding reveals the complex and hidden responses of chironomids to multiple stressors

description: Additional file 3. Publically available chironomid COI sequences from specimens sampled in Germany from BOLD(downloaded 01.06.2017).
DOI: 10.6084/m9.figshare.6859010
title: MOESM2 of DNA metabarcoding reveals the complex and hidden responses of chironomids to multiple stressors

description: Additional file 2. Primer combinations.
DOI: 10.6084/m9.figshare.6859010.v1
title: MOESM2 of DNA metabarcoding reveals the complex and hidden responses of chironomids to multiple stressors

description: Additional file 2. Primer combinations.
DOI: 10.6084/m9.figshare.6858989
title: MOESM1 of DNA metabarcoding reveals the complex and hidden responses of chironomids to multiple stressors

description: Additional file 1. Chironomid specimen abundance, dry mass, DNA concentrations, and library details.
DOI: 10.6084/m9.figshare.6858989.v1
title: MOESM1 of DNA metabarcoding reveals the complex and hidden responses of chironomids to multiple stressors

description: Additional file 1. Chironomid specimen abundance, dry mass, DNA concentrations, and library details.
DOI: 10.6084/m9.figshare.6858956
title: Additional file 9: of A comparison of heat-stress transcriptome changes between wild-type Arabidopsis pollen and a heat-sensitive mutant harboring a knockout of cyclic nucleotide-gated cation channel 16 (cngc16)

description: Sorted lists of differentially expressed transcripts in WT and cngc16 mutant. HS-dependent changes were sorted and extracted from the entire transcriptome analysis in Additional file 3. For genes listed in a given category, corresponding transcripts showed â Ľ2-fold change with an adjusted p-value â ¤0.01. a. Tally of 21 pre-existing transcriptome differences identified in a direct comparison between WT and cngc16 mutant pollen from unstressed (control/normal) plants. b. Tally of 471 HS-dependent transcriptome changes that were only classified as significant changes in WT. Genes shown include only WT-specific changes and do not include changes that were also observed to be in common with cngc16 (see Additional file 9d). c. Tally of 2305 HS-dependent transcriptome changes that were only classified as significant changes in cngc16. Genes shown include only cngc16-specific changes and do not include changes that were also observed to be in common with WT (see Additional file 9d). d. Tally of 1631 HS-dependent transcriptome changes observed in both WT and cngc16. Genes shown include only common changes and do not include changes that were categorized as specific to WT or cngc16 (see Additional file 9b and c, respectively). e. 192 transcriptome differences from a direct comparison between heat-stressed WT and cngc16 mutant pollen. (XLSX 1638 kb)
DOI: 10.6084/m9.figshare.6858956.v1
title: Additional file 9: of A comparison of heat-stress transcriptome changes between wild-type Arabidopsis pollen and a heat-sensitive mutant harboring a knockout of cyclic nucleotide-gated cation channel 16 (cngc16)

description: Sorted lists of differentially expressed transcripts in WT and cngc16 mutant. HS-dependent changes were sorted and extracted from the entire transcriptome analysis in Additional file 3. For genes listed in a given category, corresponding transcripts showed â Ľ2-fold change with an adjusted p-value â ¤0.01. a. Tally of 21 pre-existing transcriptome differences identified in a direct comparison between WT and cngc16 mutant pollen from unstressed (control/normal) plants. b. Tally of 471 HS-dependent transcriptome changes that were only classified as significant changes in WT. Genes shown include only WT-specific changes and do not include changes that were also observed to be in common with cngc16 (see Additional file 9d). c. Tally of 2305 HS-dependent transcriptome changes that were only classified as significant changes in cngc16. Genes shown include only cngc16-specific changes and do not include changes that were also observed to be in common with WT (see Additional file 9d). d. Tally of 1631 HS-dependent transcriptome changes observed in both WT and cngc16. Genes shown include only common changes and do not include changes that were categorized as specific to WT or cngc16 (see Additional file 9b and c, respectively). e. 192 transcriptome differences from a direct comparison between heat-stressed WT and cngc16 mutant pollen. (XLSX 1638 kb)
DOI: 10.6084/m9.figshare.6858941
title: Additional file 8: of A comparison of heat-stress transcriptome changes between wild-type Arabidopsis pollen and a heat-sensitive mutant harboring a knockout of cyclic nucleotide-gated cation channel 16 (cngc16)

description: Predicted targets for HS-modulated microRNAs. Target predictions for microRNAs were conducted with psRNATarget ( http://plantgrn.noble.org/psRNATarget/ , Dia and Zhao 2011 (PMCID: PMC3125753 [28])) using Arabidopsis thaliana unigene library (2017 update). MIR156A and C have the same targets. ND stands for not detected in current pollen transcriptome study. NA stands for not applicable because no target was predicted using psTarget. (XLSX 57 kb)
DOI: 10.6084/m9.figshare.6858941.v1
title: Additional file 8: of A comparison of heat-stress transcriptome changes between wild-type Arabidopsis pollen and a heat-sensitive mutant harboring a knockout of cyclic nucleotide-gated cation channel 16 (cngc16)

description: Predicted targets for HS-modulated microRNAs. Target predictions for microRNAs were conducted with psRNATarget ( http://plantgrn.noble.org/psRNATarget/ , Dia and Zhao 2011 (PMCID: PMC3125753 [28])) using Arabidopsis thaliana unigene library (2017 update). MIR156A and C have the same targets. ND stands for not detected in current pollen transcriptome study. NA stands for not applicable because no target was predicted using psTarget. (XLSX 57 kb)
DOI: 10.6084/m9.figshare.6858929
title: Additional file 7: of A comparison of heat-stress transcriptome changes between wild-type Arabidopsis pollen and a heat-sensitive mutant harboring a knockout of cyclic nucleotide-gated cation channel 16 (cngc16)

description: RNA-Seq validation using real-time Q-PCR. a. Comparison of expression values obtained from Q-PCR and RNA-Seq normalized to WT control (normal). The analysis was performed on two different reference genes separately (CYCP2 (AT3G21870) and UBQ7 (AT2G35635)). b. Primer sequences used for real-time Q-PCR. (XLSX 16 kb)