cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.3187573
title: Targeting the <i>MIR34C-5p</i>-ATG4B-autophagy axis enhances the sensitivity of cervical cancer cells to pirarubicin

description: Pirarubicin (THP) is a newer generation anthracycline anticancer drug. In the clinic, THP and THP-based combination therapies have been demonstrated to be effective against various tumors without severe side effects. However, previous clinical studies have shown that most patients with cervical cancer are not sensitive to THP treatment, and the associated mechanisms are not clear. Consistent with the clinical study, we confirmed that cervical cancer cells were resistant to THP in vitro and in vivo. Our data demonstrated that THP induced a protective macroautophagy/autophagy response in cervical cancer cells, and suppression of this autophagy dramatically enhanced the cytotoxicity of THP. By scanning the mRNA level change of autophagy-related genes, we found that the upregulation of <i>ATG4B</i> (autophagy-related 4B cysteine peptidase) plays an important role in THP-induced autophagy. Moreover, THP increased the mRNA level of <i>ATG4B</i> in cervical cancer cells by promoting mRNA stability without influencing its transcription. Furthermore, THP triggered a downregulation of <i>MIR34C-5p</i>, which was associated with the upregulation of <i>ATG4B</i> and autophagy induction. Overexpression of <i>MIR34C-5p</i> significantly decreased the level of ATG4B and attenuated autophagy, accompanied by enhanced cell death and apoptosis in THP-treated cervical cancer cells. These results for the first time reveal the presence of a <i>MIR34C-5p</i>-ATG4B-autophagy signaling axis in THP-treated cervical cancer cells in vitro and in vivo, and the axis, at least partially, accounts for the THP nonsensitivity in cervical cancer patients. This study may provide a new insight for improving the chemotherapeutic effect of THP, which may be beneficial to the further clinical application of THP in cervical cancer treatment.
DOI: 10.6084/m9.figshare.3187573.v1
title: Targeting the <i>MIR34C-5p</i>-ATG4B-autophagy axis enhances the sensitivity of cervical cancer cells to pirarubicin

description: Pirarubicin (THP) is a newer generation anthracycline anticancer drug. In the clinic, THP and THP-based combination therapies have been demonstrated to be effective against various tumors without severe side effects. However, previous clinical studies have shown that most patients with cervical cancer are not sensitive to THP treatment, and the associated mechanisms are not clear. Consistent with the clinical study, we confirmed that cervical cancer cells were resistant to THP in vitro and in vivo. Our data demonstrated that THP induced a protective macroautophagy/autophagy response in cervical cancer cells, and suppression of this autophagy dramatically enhanced the cytotoxicity of THP. By scanning the mRNA level change of autophagy-related genes, we found that the upregulation of <i>ATG4B</i> (autophagy-related 4B cysteine peptidase) plays an important role in THP-induced autophagy. Moreover, THP increased the mRNA level of <i>ATG4B</i> in cervical cancer cells by promoting mRNA stability without influencing its transcription. Furthermore, THP triggered a downregulation of <i>MIR34C-5p</i>, which was associated with the upregulation of <i>ATG4B</i> and autophagy induction. Overexpression of <i>MIR34C-5p</i> significantly decreased the level of ATG4B and attenuated autophagy, accompanied by enhanced cell death and apoptosis in THP-treated cervical cancer cells. These results for the first time reveal the presence of a <i>MIR34C-5p</i>-ATG4B-autophagy signaling axis in THP-treated cervical cancer cells in vitro and in vivo, and the axis, at least partially, accounts for the THP nonsensitivity in cervical cancer patients. This study may provide a new insight for improving the chemotherapeutic effect of THP, which may be beneficial to the further clinical application of THP in cervical cancer treatment.
DOI: 10.6084/m9.figshare.3187575.v2
title: Autophagy initiation correlates with the autophagic flux in 3D models of mesothelioma and with patient outcome

description: Understanding the role of autophagy in cancer has been limited by the inability to measure this dynamic process in formalin-fixed tissue. We considered that 3-dimensional models including ex vivo tumor, such as we have developed for studying mesothelioma, would provide valuable insights. Using these models, in which we could use lysosomal inhibitors to measure the autophagic flux, we sought a marker of autophagy that would be valid in formalin-fixed tumor and be used to assess the role of autophagy in patient outcome. Autophagy was studied in mesothelioma cell lines, as 2-dimensional (2D) monolayers and 3-dimensional (3D) multicellular spheroids (MCS), and in tumor from 25 chemonaive patients, both as ex vivo 3D tumor fragment spheroids (TFS) and as formalin-fixed tissue. Autophagy was evaluated as autophagic flux by detection of the accumulation of LC3 after lysosomal inhibition and as autophagy initiation by detection of ATG13 puncta. We found that autophagic flux in 3D, but not in 2D, correlated with ATG13 positivity. In each TFS, ATG13 positivity was similar to that of the original tumor. When tested in tissue microarrays of 109 chemonaive patients, higher ATG13 positivity correlated with better prognosis and provided information independent of known prognostic factors. Our results show that ATG13 is a static marker of the autophagic flux in 3D models of mesothelioma and may also reflect autophagy levels in formalin-fixed tumor. If confirmed, this marker would represent a novel prognostic factor for mesothelioma, supporting the notion that autophagy plays an important role in this cancer.
DOI: 10.6084/m9.figshare.3187603.v4
title: SciENcv-OpenRIF Integration

description: This presentation was given as part of the OpenRIF workshop on April 17, 2016 at the FORCE2016 conference. It provides background on the SciENcv system, the goals of integrating it with OpenRIF, and some details on how the integration is being accomplished.<br>
DOI: 10.6084/m9.figshare.3187603.v3
title: SciENcv-OpenRIF Integration

description: This presentation was given as part of the OpenRIF workshop on April 17, 2016 at the FORCE2016 conference. It provides background on the SciENcv system, the goals of integrating it with OpenRIF, and some details on how the integration is being accomplished.<br>
DOI: 10.6084/m9.figshare.3187555
title: FANCI is a negative regulator of Akt activation

description: Akt is a critical mediator of the oncogenic PI3K pathway, and its activation is regulated by kinases and phosphatases acting in opposition. We report here the existence of a novel protein complex that is composed minimally of Akt, PHLPP1, PHLPP2, FANCI, FANCD2, USP1 and UAF1. Our studies show that depletion of FANCI, but not FANCD2 or USP1, results in increased phosphorylation and activation of Akt. This activation is due to a reduction in the interaction between PHLPP1 and Akt in the absence of FANCI. In response to DNA damage or growth factor treatment, the interactions between Akt, PHLPP1 and FANCI are reduced consistent with the known phosphorylation of Akt in response to these stimuli. Furthermore, depletion of FANCI results in reduced apoptosis after DNA damage in accord with its role as a negative regular of Akt. Our findings describe an unexpected function for FANCI in the regulation of Akt and define a previously unrecognized intersection between the PI3K-Akt and FA pathways.
DOI: 10.6084/m9.figshare.3187555.v1
title: FANCI is a negative regulator of Akt activation

description: Akt is a critical mediator of the oncogenic PI3K pathway, and its activation is regulated by kinases and phosphatases acting in opposition. We report here the existence of a novel protein complex that is composed minimally of Akt, PHLPP1, PHLPP2, FANCI, FANCD2, USP1 and UAF1. Our studies show that depletion of FANCI, but not FANCD2 or USP1, results in increased phosphorylation and activation of Akt. This activation is due to a reduction in the interaction between PHLPP1 and Akt in the absence of FANCI. In response to DNA damage or growth factor treatment, the interactions between Akt, PHLPP1 and FANCI are reduced consistent with the known phosphorylation of Akt in response to these stimuli. Furthermore, depletion of FANCI results in reduced apoptosis after DNA damage in accord with its role as a negative regular of Akt. Our findings describe an unexpected function for FANCI in the regulation of Akt and define a previously unrecognized intersection between the PI3K-Akt and FA pathways.
DOI: 10.6084/m9.figshare.3187549
title: Weather Dataset

description: This is a version of the weather dataset used in the following paper:<br><i>Data Polygamy: The Many-Many Relationships among Urban Spatio-Temporal Data Sets, F. Chirigati, H. Doraiswamy, T. Damoulas, and J. Freire. In Proceedings of the 2016 ACM SIGMOD International Conference on Management of Data (SIGMOD), 2016</i><br>The dataset includes records of weather data for New York City, from 2010 to 2014.<br>The original data is available at the National Climatic Data Center website: http://www7.ncdc.noaa.gov/CDO/dataproduct
DOI: 10.6084/m9.figshare.3187539
title: 311 Dataset

description: This is a version of the 311 dataset used in the following paper:<br><i>Data Polygamy: The Many-Many Relationships among Urban Spatio-Temporal Data Sets, F. Chirigati, H. Doraiswamy, T. Damoulas, and J. Freire. In Proceedings of the 2016 ACM SIGMOD International Conference on Management of Data (SIGMOD), 2016</i><br>The dataset includes records from 311, a telephone number that provides non-emergency services to New York City, from 2003 to 2014.<br>The original data is available at the NYC Open Data portal: https://data.cityofnewyork.us/d/erm2-nwe9?category=Social-Services&view_name=311-Service-Requests-from-2010-to-Present
DOI: 10.6084/m9.figshare.3187571.v1
title: NUP98 Fusion Oncoproteins Interact with the APC/C<sup>Cdc20</sup> as a Pseudosubstrate and Prevent Mitotic Checkpoint Complex binding

description: <i>NUP98</i> is a recurrent partner gene in translocations causing acute myeloid leukemias and myelodisplastic syndrome. The expression of NUP98 fusion oncoproteins has been shown to induce mitotic spindle defects and chromosome missegregation, which correlate with the capability of NUP98 fusions to cause mitotic checkpoint attenuation. We show that NUP98 oncoproteins physically interact with the APC/C<sup>Cdc20</sup> in the absence of the NUP98 partner protein RAE1, and prevent the binding of the mitotic checkpoint complex to the APC/C<sup>Cdc20</sup>. NUP98 oncoproteins require the GLEBS-like domain present in their NUP98 moiety to bind the APC/C<sup>Cdc20</sup>. We found that NUP98 wild-type is a substrate of APC/C<sup>Cdc20</sup> prior to mitotic entry, and that its binding to APC/C<sup>Cdc20</sup> is controlled via phosphorylation of a PEST sequence located within its C-terminal portion. We identify S606, within the PEST sequence, as a key target site, whose phosphorylation modulates the capability of NUP98 to interact with APC/C<sup>Cdc20</sup>. We finally provide evidence for an involvement of the peptidyl-prolyl isomerase PIN1 in modulating the possible conformational changes within NUP98 that lead to its dissociation from the APC/C<sup>Cdc20</sup> during mitosis. Our results provide novel insight into the mechanisms underlying the aberrant capability of NUP98 oncoproteins to interact with APC/C<sup>Cdc20</sup> and to interfere with its function.
DOI: 10.6084/m9.figshare.3187533
title: Coburn_PONE-D-16-09747_rawdatasets.pdf

description: These are sets of raw data included in Coburn et al., Bloodstream-to-Eye Infections are Facilitated by Outer Blood-Retinal Barrier Dysfunction, submitted to PLoSOne in April 2016. Data sets are included in Figures 1 and 2 and Tables 1 and 2 (denoted on each data set).
DOI: 10.6084/m9.figshare.3187539.v1
title: 311 Dataset

description: This is a version of the 311 dataset used in the following paper:<br><i>Data Polygamy: The Many-Many Relationships among Urban Spatio-Temporal Data Sets, F. Chirigati, H. Doraiswamy, T. Damoulas, and J. Freire. In Proceedings of the 2016 ACM SIGMOD International Conference on Management of Data (SIGMOD), 2016</i><br>The dataset includes records from 311, a telephone number that provides non-emergency services to New York City, from 2003 to 2014.<br>The original data is available at the NYC Open Data portal: https://data.cityofnewyork.us/d/erm2-nwe9?category=Social-Services&view_name=311-Service-Requests-from-2010-to-Present
DOI: 10.6084/m9.figshare.3187531
title: Gas Prices Dataset

description: This is a version of the gas prices dataset used in the following paper:<br><i>Data Polygamy: The Many-Many Relationships among Urban Spatio-Temporal Data Sets, F. Chirigati, H. Doraiswamy, T. Damoulas, and J. Freire. In Proceedings of the 2016 ACM SIGMOD International Conference on Management of Data (SIGMOD), 2016</i><br>The dataset includes records of the average gasoline price in dollars per gallon for New York, from 2000 to 2014. The original data is available at the U.S. Energy Information Administration website: https://www.eia.gov/petroleum/gasdiesel/xls/pswrgvwall.xls
DOI: 10.6084/m9.figshare.3187535
title: Vehicle Collisions

description: This is a version of the vehicle collisions dataset used in the following paper:<br><i>Data Polygamy: The Many-Many Relationships among Urban Spatio-Temporal Data Sets, F. Chirigati, H. Doraiswamy, T. Damoulas, and J. Freire. In Proceedings of the 2016 ACM SIGMOD International Conference on Management of Data (SIGMOD), 2016</i><br>The dataset includes traffic collision data provided by NYPD, from 2012 to 2014.<br>The original data is available at the NYC Open Data portal: https://data.cityofnewyork.us/d/h9gi-nx95?category=Public-Safety&view_name=NYPD-Motor-Vehicle-Collisions
DOI: 10.6084/m9.figshare.3187535.v1
title: Vehicle Collisions

description: This is a version of the vehicle collisions dataset used in the following paper:<br><i>Data Polygamy: The Many-Many Relationships among Urban Spatio-Temporal Data Sets, F. Chirigati, H. Doraiswamy, T. Damoulas, and J. Freire. In Proceedings of the 2016 ACM SIGMOD International Conference on Management of Data (SIGMOD), 2016</i><br>The dataset includes traffic collision data provided by NYPD, from 2012 to 2014.<br>The original data is available at the NYC Open Data portal: https://data.cityofnewyork.us/d/h9gi-nx95?category=Public-Safety&view_name=NYPD-Motor-Vehicle-Collisions
DOI: 10.6084/m9.figshare.3187337
title: Evaluation Data for IJDL Experiments

description: Two excel sheets presenting the raw evaluations and subsequent data analysis for two term extraction experiments as reported in the paper "Evaluating Unsupervised Thesaurus-based Labeling of Audiovisual Content in an Archive Production Environment" by de Boer et al. to appear in IJDL <br>experiment1_data.xslx contains the raw evaluations and subsequent evaluations for the experiment described in Section 4 of that paper. This includes the Pearson correlation coefficient calculations. <br>experiment2_data.xslx contains the raw evaluations and subsequent evaluations for the experiment described in Section 5 of that paper.
DOI: 10.6084/m9.figshare.3187337.v1
title: Evaluation Data for IJDL Experiments

description: Two excel sheets presenting the raw evaluations and subsequent data analysis for two term extraction experiments as reported in the paper "Evaluating Unsupervised Thesaurus-based Labeling of Audiovisual Content in an Archive Production Environment" by de Boer et al. to appear in IJDL <br>experiment1_data.xslx contains the raw evaluations and subsequent evaluations for the experiment described in Section 4 of that paper. This includes the Pearson correlation coefficient calculations. <br>experiment2_data.xslx contains the raw evaluations and subsequent evaluations for the experiment described in Section 5 of that paper.
DOI: 10.15468/dl.2pqu4n
title: Occurrence Download

description: A dataset containing 3 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Medinilla richardsii Regalado"
 ]
}

 The dataset includes 3 records from 2 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0056178-240321170329656/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.5281/zenodo.8265693
title: ION Exchangeable Glasses Dataset

description: Ion-exchangeable glasses dataset.
DOI: 10.5281/zenodo.8265694
title: Depth Of Layer (DOL) Prediction Dataset

description: Dataset for Depth Of Layer (DOL) prediction in ion-exchangeable glasses.
DOI: 10.15468/dl.pnghk9
title: Occurrence Download

description: A dataset containing 17 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Myoporum mauritianum A.DC."
 ]
}

 The dataset includes 17 records from 6 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0056179-240321170329656/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.x4ngqx
title: Occurrence Download

description: A dataset containing 6 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Mucuna macropoda Baker f."
 ]
}

 The dataset includes 6 records from 5 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0056182-240321170329656/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.g28hhx
title: Occurrence Download

description: A dataset containing 43 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Mimusops riparia Engl."
 ]
}

 The dataset includes 43 records from 10 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0056181-240321170329656/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.vwfbmd
title: Occurrence Download

description: A dataset containing 10 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Memecylon laureolum Jacq.-Fél."
 ]
}

 The dataset includes 10 records from 4 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0056183-240321170329656/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.xqwwxm
title: Occurrence Download

description: A dataset containing 14 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Medinilla ridleyi Merr."
 ]
}

 The dataset includes 14 records from 4 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0056184-240321170329656/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.9dmvtr
title: Occurrence Download

description: A dataset containing 27 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Mucuna manongarivensis Du Puy & Labat"
 ]
}

 The dataset includes 27 records from 6 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0056185-240321170329656/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.fgeegc
title: Occurrence Download

description: A dataset containing 52 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Mimusops sambiranensis Aubrév."
 ]
}

 The dataset includes 52 records from 5 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0056188-240321170329656/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.dh7svz
title: Occurrence Download

description: A dataset containing 8 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Myoporum papuanum Kraenzl."
 ]
}

 The dataset includes 8 records from 3 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0056186-240321170329656/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.prctxy
title: Occurrence Download

description: A dataset containing 255 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Microsorum rampans (Baker) Parris"
 ]
}

 The dataset includes 255 records from 16 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0056189-240321170329656/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.6084/m9.figshare.25508686
title: <b>Impact of the newly compiled Tai Chi (BaFa WuBu) on vascular health in middle-aged and older postmenopausal women: an analysis of the long-term intervention effect of a 24-week RCT</b>

description: Background: cardiovascular disease (CVD) is a common health problem in middle-aged and older populations, with aging of the cardiovascular system being particularly significant. The risk of developing CVD increases significantly as women become postmenopausal, partly attributed to decreasing estrogen levels. Atherosclerosis is one of the major pathogenic mechanisms of CVD, and postmenopausal women are more likely to develop atherosclerosis and abnormal vascular endothelial function. Exercise exercise is considered an effective means to improve cardiovascular function and reduce the risk of CVD, and the traditional Chinese tai chi exercise has received much attention. However, the current exercise intervention cycle is short, the selection of indicators is not perfect, and for special populations, such as middle-aged and elderly menopausal women, it is difficult to adhere to and complete routine exercise, thus limiting the intervention effect. Therefore, the present study was the first to systematically assess the effects of the newly developed Tai Chi (BaFa WuBu) on vascular health in middle-aged and elderly postmenopausal women.As a summary of the core taijiquan techniques, Tai Chi (BaFa WuBu) is easier to train and is more suitable for special populations. Using a 24-week long-term intervention program, this study aims to provide a scientific basis for improving the vascular health of middle-aged and elderly postmenopausal women and to explore a new safe training method.
DOI: 10.5281/zenodo.10895194
title: haemulon_aurolineatum_spades_01.fasta.gz

description: .
DOI: 10.5281/zenodo.10895195
title: haemulon_aurolineatum_spades_01.fasta.gz

description: .
DOI: 10.15468/dl.py9rkk
title: Occurrence Download

description: A dataset containing 372253 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Beryx splendens Lowe, 1834"
 ]
}

 The dataset includes 372253 records from 102 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0056169-240321170329656/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.8aeqpd
title: Occurrence Download

description: A dataset containing 6 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Memecylon lawsonii Gamble"
 ]
}

 The dataset includes 6 records from 3 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0056190-240321170329656/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.