cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.21918809
title: Inhibition of autophagy in microglia and macrophages exacerbates innate immune responses and worsens brain injury outcomes

description: Excessive and prolonged neuroinflammation following traumatic brain injury (TBI) contributes to long-term tissue damage and poor functional outcomes. However, the mechanisms contributing to exacerbated inflammatory responses after brain injury remain poorly understood. Our previous work showed that macroautophagy/autophagy flux is inhibited in neurons following TBI in mice and contributes to neuronal cell death. In the present study, we demonstrate that autophagy is also inhibited in activated microglia and infiltrating macrophages, and that this potentiates injury-induced neuroinflammatory responses. Macrophage/microglia-specific knockout of the essential autophagy gene <i>Becn1</i> led to overall increase in neuroinflammation after TBI. In particular, we observed excessive activation of the innate immune responses, including both the type-I interferon and inflammasome pathways. Defects in microglial and macrophage autophagy following injury were associated with decreased phagocytic clearance of danger/damage-associated molecular patterns (DAMP) responsible for activation of the cellular innate immune responses. Our data also demonstrated a role for precision autophagy in targeting and degradation of innate immune pathways components, such as the NLRP3 inflammasome. Finally, inhibition of microglial/macrophage autophagy led to increased neurodegeneration and worse long-term cognitive outcomes after TBI. Conversely, increasing autophagy by treatment with rapamycin decreased inflammation and improved outcomes in wild-type mice after TBI. Overall, our work demonstrates that inhibition of autophagy in microglia and infiltrating macrophages contributes to excessive neuroinflammation following brain injury and in the long term may prevent resolution of inflammation and tissue regeneration. <b>Abbreviations:</b><i>Becn1</i>/BECN1, beclin 1, autophagy related; CCI, controlled cortical impact; <i>Cybb</i>/CYBB/NOX2: cytochrome b-245, beta polypeptide; DAMP, danger/damage-associated molecular patterns; <i>Il1b</i>/IL1B/Il-1β, interleukin 1 beta; LAP, LC3-associated phagocytosis; <i>Map1lc3b</i>/MAP1LC3/LC3, microtubule-associated protein 1 light chain 3 beta; <i>Mefv</i>/MEFV/TRIM20: Mediterranean fever; <i>Nos2</i>/NOS2/iNOS: nitric oxide synthase 2, inducible; <i>Nlrp3</i>/NLRP3, NLR family, pyrin domain containing 3; <i>Sqstm1</i>/SQSTM1/p62, sequestosome 1; TBI, traumatic brain injury; <i>Tnf</i>/TNF/TNF-α, tumor necrosis factor; <i>Ulk1</i>/ULK1, unc-51 like kinase 1.
DOI: 10.34740/kaggle/ds/3391387
title: Accelerometer CaseStudy Dataset
DOI: 10.5281/zenodo.8060528
title: OMERO Server BDV H5 Test Example

description: This is an example H5 file that loads and displays properly in BioFormats, but only loads into OMERO server. The OMERO server display does not work.
DOI: 10.5281/zenodo.8006981
title: Supplementary data for Long-term trends in functional diversity of exploited marine fish in the Azores archipelago: past and present

description: Supplementary infromation for the manuscript entitled "<strong>Long-term trends in functional diversity of exploited marine fish in the Azores’ archipelago: past and present</strong>"
description: This work was performed under the framework of the project FunAzores co-funded by AÇORES 2020, through the FEDER fund from the European Union: ACORES 01-0145-FEDER-000123.
DOI: 10.5281/zenodo.8006982
title: Supplementary data for Long-term trends in functional diversity of exploited marine fish in the Azores archipelago: past and present

description: Supplementary infromation for the manuscript entitled "<strong>Long-term trends in functional diversity of exploited marine fish in the Azores’ archipelago: past and present</strong>"
description: This work was performed under the framework of the project FunAzores co-funded by AÇORES 2020, through the FEDER fund from the European Union: ACORES 01-0145-FEDER-000123.
DOI: 10.5281/zenodo.8060527
title: OMERO Server BDV H5 Test Example

description: This is an example H5 file that loads and displays properly in BioFormats, but only loads into OMERO server. The OMERO server display does not work.
DOI: 10.13012/b2idb-9766947_v1
title: Data for "Eastern banded killifish (Fundulus diaphanus diaphanus) in Lake Michigan and connected watersheds: the invasion of a non-native subspecies"

description: Data associated with the manuscript "Eastern banded killifish (Fundulus diaphanus diaphanus) in Lake Michigan and connected watersheds: the invasion of a non-native subspecies" by Jordan H. Hartman, Jeremy S. Tiemann, Joshua L. Sherwood, Philip W. Willink, Kurt T. Ash, Mark A. Davis, and Eric R. Larson. For this project, we sampled 109 locations in Lake Michigan and connected waters and found 821 total banded killifish. Using mitochondrial DNA analysis, we found 31 eastern and 25 western haplotypes which split our banded killifish into 422 eastern banded killifish and 398 western banded killifish. This dataset provides the sampling locations, banded killifish haplotypes, frequency of those haplotypes per location, accession numbers in GenBank, and the associated mitochondrial DNA sequences.
DOI: 10.34740/kaggle/dsv/5980762
title: Nigerian Presidential Election 2023 Tweets
DOI: 10.34740/kaggle/ds/3367348
title: Election Forcast Dataset
DOI: 10.34740/kaggle/dsv/5932003
title: DISCOVR_SOT_cultivation-composition
DOI: 10.5281/zenodo.8042840
title: Evaluation Data - Systematic Assessment of Fuzzers using Mutation Analysis

description: The Databases which contain the results of the experiments done for the paper: "Systematic Assessment of Fuzzers using Mutation Analysis" Contained are the databases for the basic, ASan, and 24 hour runs under the data directory. The seed<em> </em>corpora are found in the directory seeds, minimal directory contains the initial seeds used for coverage fuzzing, the coverage directory contains the seeds that resulted from coverage fuzzing. To reproduce the results in the paper from scratch all that is required is the seed/minimal directory, all other artifacts are produced from this data. Additionally, the results of the two manual analyses are contained: not_killed_24.xlsx contain the notes of the manual analysis of unkilled mutants even after the 24 hour experiment, see Section 5.2.1. CVEs.xlsx are the notes taken during for the manual analysis of which CVEs can be reproduced mutants as described in Section 5.4. The script to collect the CVEs is provided as well under cve-script.7z.
DOI: 10.5281/zenodo.8042841
title: Evaluation Data - Systematic Assessment of Fuzzers using Mutation Analysis

description: The Databases which contain the results of the experiments done for the paper: "Systematic Assessment of Fuzzers using Mutation Analysis" Contained are the databases for the basic, ASan, and 24 hour runs under the data directory. The seed<em> </em>corpora are found in the directory seeds, minimal directory contains the initial seeds used for coverage fuzzing, the coverage directory contains the seeds that resulted from coverage fuzzing. To reproduce the results in the paper from scratch all that is required is the seed/minimal directory, all other artifacts are produced from this data. Additionally, the results of the two manual analyses are contained: not_killed_24.xlsx contain the notes of the manual analysis of unkilled mutants even after the 24 hour experiment, see Section 5.2.1. CVEs.xlsx are the notes taken during for the manual analysis of which CVEs can be reproduced mutants as described in Section 5.4. The script to collect the CVEs is provided as well under cve-script.7z.
DOI: 10.5281/zenodo.8060560
title: Evaluation Data - Systematic Assessment of Fuzzers using Mutation Analysis

description: The Databases which contain the results of the experiments done for the paper: "Systematic Assessment of Fuzzers using Mutation Analysis" Contained are the databases for the basic, ASan, and 24 hour runs under the data directory. The seed<em> </em>corpora are found in the directory seeds, minimal directory contains the initial seeds used for coverage fuzzing, the coverage directory contains the seeds that resulted from coverage fuzzing. To reproduce the results in the paper from scratch all that is required is the seed/minimal directory, all other artifacts are produced from this data. Additionally, the results of the two manual analyses are contained: not_killed_24.xlsx contain the notes of the manual analysis of unkilled mutants even after the 24 hour experiment, see Section 5.2.1. CVEs.xlsx are the notes taken during for the manual analysis of which CVEs can be reproduced mutants as described in Section 5.4. The script to collect the CVEs is provided as well under cve-script.7z.
DOI: 10.34740/kaggle/dsv/5980884
title: Mahanagar Yatayat Dataset
DOI: 10.6084/m9.figshare.23546223
title: Detection and phylogenetic analysis of highly pathogenic A/H5N1 avian influenza clade 2.3.4.4b virus in Chile, 2022

description: Highly pathogenic avian influenza (HPAI) A/H5N1 viruses continue to pose a significant threat to animal and human health worldwide. In late 2022, the first confirmed case of HPAI A/H5N1 infection in wild birds in Chile near the Chilean-Peruvian border was reported. Active surveillance by our group in the adyacent Lluta river estuary revealed an increase in A/H5N1 prevalence coinciding with the arrival of migratory birds from the Northern Hemisphere. Genomic analysis of A/H5N1-positive samples demonstrated a close genetic relationship to strains detected in Peru during the same period, which originated from A/H5N1 viruses causing outbreaks in North America. Notably, we identified genetic mutations that did not correlate with known enhanced transmission or binding traits to mammalian receptors. In summary, this study provides valuable genomic insights into the A/H5N1 Clade 2.3.4.4b viruses in wild birds in Chile, emphasizing the need for enhanced surveillance and response strategies to mitigate the threat posed by these highly pathogenic avian influenza viruses in South America.
DOI: 10.6084/m9.figshare.23546223.v1
title: Detection and phylogenetic analysis of highly pathogenic A/H5N1 avian influenza clade 2.3.4.4b virus in Chile, 2022

description: Highly pathogenic avian influenza (HPAI) A/H5N1 viruses continue to pose a significant threat to animal and human health worldwide. In late 2022, the first confirmed case of HPAI A/H5N1 infection in wild birds in Chile near the Chilean-Peruvian border was reported. Active surveillance by our group in the adyacent Lluta river estuary revealed an increase in A/H5N1 prevalence coinciding with the arrival of migratory birds from the Northern Hemisphere. Genomic analysis of A/H5N1-positive samples demonstrated a close genetic relationship to strains detected in Peru during the same period, which originated from A/H5N1 viruses causing outbreaks in North America. Notably, we identified genetic mutations that did not correlate with known enhanced transmission or binding traits to mammalian receptors. In summary, this study provides valuable genomic insights into the A/H5N1 Clade 2.3.4.4b viruses in wild birds in Chile, emphasizing the need for enhanced surveillance and response strategies to mitigate the threat posed by these highly pathogenic avian influenza viruses in South America.
DOI: 10.5281/zenodo.8040140
title: USGS data as part of FloodsNet dataset

description: USGS data as part of FloodsNet dataset
DOI: 10.5281/zenodo.8040141
title: USGS data as part of FloodsNet dataset

description: USGS data as part of FloodsNet dataset
DOI: 10.5281/zenodo.8040541
title: USGS data as part of FloodsNet dataset

description: USGS data as part of FloodsNet dataset
DOI: 10.5281/zenodo.8060630
title: USGS data as part of FloodsNet dataset

description: USGS data as part of FloodsNet dataset
DOI: 10.34740/kaggle/ds/3421896
title: UK-Export🚒
DOI: 10.5519/qd.ingua7px
title: Query on the Natural History Museum Data Portal (data.nhm.ac.uk) (2 records)
DOI: 10.5281/zenodo.8060401
title: Regional estimates of gross primary production applying the process-based model 3D-CMCC-FEM vs. multiple datasets

description: This repository contains the model 3D-CMCC-FEM v5.6 executable (Testolin et al.2023), model inputs and model outputs in the folder RUN_BASILICATA; scripts to prepare model inputs and perform model outputs post-processing in SCRIPTS; remote-sensing based data and forcing in DATA; tables and post-processed files in OUTPUT; figures in FIGURE, related to the manuscript entitled “Regional estimates of gross primary production applying the process-based model 3D-CMCC-FEM vs. multiple datasets”
description: {"references": ["Testolin et al.2023 Simulating diverse forest management options in a changing climate on a Pinus nigra subsp. laricio plantation in Southern Italy. Science of the Total Environment https://doi.org/10.1016/j.scitotenv.2022.159361", "\"Regional estimates of gross primary production applying the process-based model 3D-CMCC-FEM vs. multiple datasets \" DOI: 10.1101/2023.06.13.544712"]}
DOI: 10.5281/zenodo.8060400
title: Regional estimates of gross primary production applying the process-based model 3D-CMCC-FEM vs. multiple datasets

description: This repository contains the model 3D-CMCC-FEM v5.6 executable (Testolin et al.2023), model inputs and model outputs in the folder RUN_BASILICATA; scripts to prepare model inputs and perform model outputs post-processing in SCRIPTS; remote-sensing based data and forcing in DATA; tables and post-processed files in OUTPUT; figures in FIGURE, related to the manuscript entitled “Regional estimates of gross primary production applying the process-based model 3D-CMCC-FEM vs. multiple datasets”
description: {"references": ["Testolin et al.2023 Simulating diverse forest management options in a changing climate on a Pinus nigra subsp. laricio plantation in Southern Italy. Science of the Total Environment https://doi.org/10.1016/j.scitotenv.2022.159361", "\"Regional estimates of gross primary production applying the process-based model 3D-CMCC-FEM vs. multiple datasets \" DOI: 10.1101/2023.06.13.544712"]}
DOI: 10.6084/m9.figshare.21644711.v1
title: FUSE_estimated_score_figshare.xlsx

description: We develop a joint estimation pipeline FUSE (<strong>Fu</strong>nctional <strong>S</strong>ubstitution <strong>E</strong>stimation) which uses assay measurements collectively to improve the accuracy of functional estimates and infer the functional effects of sites which have not been screened. Here we compiled the FUSE estimated functional scores for 13 DMS datasets and 2 base editing datasets.
DOI: 10.25919/bbsv-8054
title: Parkes observations for project P1172 semester 2023APRS_03

description: PSR J1713+0747 is a very important millisecond pulsar for global pulsar timing array campaigns, due to its long-term observation history, very stable and narrow profile and strong S/N. In April 2021, the pulsar experienced a significant event related to a change in its magnetosphere, presented as an observable change in the pulsar profile. Since then, the pulsar has been slowly recovering and we wish to observe this recovery with high-cadence observations to allow us to create a detailed time-resolved series of variations in the MSPs profile, polarisation, and other properties. Under this proposal, we wish to probe the profile recovery on weekly timescales (once per week per month), revealing additional short timescale behaviours, indicative of changes in the magnetosphere which are not available to other telescopes in the world, thanks to the Parkes UWL. This will also allow us to determine if the magnetosphere has returned to its original configuration or is settling into a new one. Understanding the recovery of this event is key for demonstrating that such pulsars are still viable clocks for use in gravitational wave studies, and in turn, provide us with new data on how the normally stable magnetosphere of this millisecond pulsar responds to an impulsive change in state.
DOI: 10.6084/m9.figshare.23546274
title: LC-MS identification

description: This result showed the mass spectrometric identification of the purified SjHNF4-LBD protein.
DOI: 10.6084/m9.figshare.23546274.v1
title: LC-MS identification

description: This result showed the mass spectrometric identification of the purified SjHNF4-LBD protein.
DOI: 10.21223/pkpxqf/0hewcd
title: 01-Data_soil_properties_Digital mapping_Huancayo.tab

description: :unav
DOI: 10.21223/pkpxqf/2gjew3
title: 02-Data_Dictionary_Digital mapping_Huancayo.tab

description: :unav
DOI: 10.21223/pkpxqf/x1ldjx
title: 03-Image_description_Digital mapping_Huancayo.tab

description: :unav
DOI: 10.21223/pkpxqf
title: Dataset for: Digital mapping of agricultural soil properties from high resolution UAV multispectral imagery

description: Traditional laboratory-based analyses are costly, and data extrapolation for mapping soil properties using high-resolution imagery becomes a computationally expensive procedure, taking days or weeks to obtain accurate results using a desktop workstation. To overcome these challenges, cloud-based solutions such as Google Earth Engine (GEE) have been used to analyze complex data with machine learning algorithms. In this study, we compared a suite of multispectral-derived soil and vegetation indices with in situ measurements of physical-chemical soil properties in agricultural lands in the Peruvian Mantaro Valley.
DOI: 10.21223/pkpxqf/nemkxp
title: Altum_Multispectral.tif

description: :unav
DOI: 10.21223/pkpxqf/swpyac
title: 05-Altum_Thermal.tif

description: :unav
DOI: 10.48366/r598493
title: Review of application of machine learning models for long term prediction of streamflow

description: Review and proposal of thorough review of application of machine learning models for long term prediction (forecasting, hindcasting) of flow (streamflow, runoff, inflow), that is, long term planning related to water resources management. Long term implies mean monthly streamflow or values of streamflow in a similar time resolution.
DOI: 10.5517/ccdc.csd.cc2f5yyj
title: CCDC 2240058: Experimental Crystal Structure Determination

description: Related Article: Chengchuang Li, Teng Zhu, Caijin Lei, Guangbin Cheng, Chuan Xiao, Hongwei Yang|2023|J.Mater.Chem.A|11|12043|doi:10.1039/D3TA01811C
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2f5yzk
title: CCDC 2240059: Experimental Crystal Structure Determination

description: Related Article: Chengchuang Li, Teng Zhu, Caijin Lei, Guangbin Cheng, Chuan Xiao, Hongwei Yang|2023|J.Mater.Chem.A|11|12043|doi:10.1039/D3TA01811C
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2f5z0m
title: CCDC 2240060: Experimental Crystal Structure Determination

description: Related Article: Chengchuang Li, Teng Zhu, Caijin Lei, Guangbin Cheng, Chuan Xiao, Hongwei Yang|2023|J.Mater.Chem.A|11|12043|doi:10.1039/D3TA01811C
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2f62tk
title: CCDC 2240178: Experimental Crystal Structure Determination

description: Related Article: Kinga Kaniewska-Laskowska, Marcin Czapla, Jarosław Chojnacki, Rafał Grubba|2023|Dalton Trans.|52|8311|doi:10.1039/D3DT01433A
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2f62vl
title: CCDC 2240179: Experimental Crystal Structure Determination

description: Related Article: Kinga Kaniewska-Laskowska, Marcin Czapla, Jarosław Chojnacki, Rafał Grubba|2023|Dalton Trans.|52|8311|doi:10.1039/D3DT01433A
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2f62wm
title: CCDC 2240180: Experimental Crystal Structure Determination

description: Related Article: Kinga Kaniewska-Laskowska, Marcin Czapla, Jarosław Chojnacki, Rafał Grubba|2023|Dalton Trans.|52|8311|doi:10.1039/D3DT01433A
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2f62xn
title: CCDC 2240181: Experimental Crystal Structure Determination

description: Related Article: Kinga Kaniewska-Laskowska, Marcin Czapla, Jarosław Chojnacki, Rafał Grubba|2023|Dalton Trans.|52|8311|doi:10.1039/D3DT01433A
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2ffw6z
title: CCDC 2247661: Experimental Crystal Structure Determination

description: Related Article: Masaharu Takatsuki, Hiroshi Aoyama, Kenichi Murai, Mitsuhiro Arisawa, Makoto Sako|2023|Chem.Commun.|59|7467|doi:10.1039/D3CC01955A
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2ffw70
title: CCDC 2247662: Experimental Crystal Structure Determination

description: Related Article: Masaharu Takatsuki, Hiroshi Aoyama, Kenichi Murai, Mitsuhiro Arisawa, Makoto Sako|2023|Chem.Commun.|59|7467|doi:10.1039/D3CC01955A
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.