cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.12095091.v1
title: Synthesis and antibacterial activity of a series novel 5,7-diisoprenyloxyflavone derivatives

description: In the present study, a series of novel 5,7-diisoprenyloxyflavone derivatives were designed, synthesized, and evaluated for their antibacterial activity. Most of these compounds displayed significant antibacterial effects against Gram-positive bacteria, especially against strains of multidrug-resistant clinical isolates. Compounds 4c, 4g, 4i, 4j, 4k, 4l, 4n, 4q and 4t showed high levels of antimicrobial activity against Staphylococcus aureus RN4220 with minimum inhibitory concentrations of 4.0-20 µM. Compound 4k showed the most potent activity among these compounds against all multidrug-resistant clinical isolates tested. Unfortunately, none of the compounds were active against Gram-negative bacteria at the doses of 24-164 µM.
DOI: 10.6084/m9.figshare.12095085
title: Evaluation of mechanical properties of grouts substituting the natural coarse aggregate for ceramic civil construction waste

description: ABSTRACT The lack of control regarding waste generation is a problem still faced by the construction industry, whereas its inputs could be used in the production of new cementitious composites, maintaining the quality, performance and sustainability of structures. This study developed grouts through the substitution of natural aggregate for residues of crushed ceramic bricks, evaluating its fresh state and mechanical properties. The samples displayed loss of workability and initial slump in fresh state, besides loss of compressive strength, elastic modulus, total water absorption and capillary water absorption in hardened state. In addition, composites with grog presented less consistency in fresh state when compared to the reference sample. The differences were even greater over time. As for the hardened state, the compressive strength of the samples was similaramong them at both ages, and all results remained above 14 MPa at 28 days, as required by ASTM C476, hence being characterized as structural grouts for masonry. For the elastic modulus test, the results were higher for samples with lower amounts of waste due to less internal voids and higher volume of natural aggregates. The substitution of natural aggregate for civil construction waste (CCW) in the mixtures increased void ratio and water absorption, while causing the lowest specific gravities of the research. Overall, the sample that presented the most satisfactory values was CCW 25%, showing that it is possible to obtain benefits from waste produced in factories and buildings, even for higher replacement levels, occasionally
DOI: 10.6084/m9.figshare.12095100.v1
title: Activated alkali cements: effect of thermal curing on the development of mechanical strength

description: ABSTRACT Due to the extraction of nonrenewable raw materials and the release of CO2 into the atmosphere by the production of Portland cement, the alkali-activated cements (AAC) have been gaining ground in the world scenario since their production process does not involve calcination of the raw materials and uses various byproducts. Thus, they are considered as a low environmental impact product and with good engineering properties. The AAC‘s can be obtained mainly from blast furnace slag (BFS), which may have origin in charcoal ovens or coke, which modifies their chemical composition. The objective of this work was to evaluate the influence of the chemical composition of BFS on the behavior of the AAC and to investigate the thermal cure efficiency in the improvement of the compressive strength. For the production of AAC, two slag, A and B, were used from charcoal kilns and coke, respectively, in addition to sodium hydroxide as an alkaline activator. The samples were subjected to thermal cure for a period of 24 hours at temperatures of 40 oC and 60o C, which were subjected to the compressive strength, calorimetry and microstructure analyzes at 3, 7 and 28 days. The results showed that slag A was more reactive and more influenced by the cure temperature. The AAC made with BFS- A (AAC / A) slag presented higher mechanical performance than B (AAC / B) at at all temperatures. Microstructure analyzes showed that in AAC/A there was a majority formation of CSH, while in CAT/B, CSH and hydrotalcite. Thermal curing was not efficient to improve the mechanical behavior of CAT / B.
DOI: 10.6084/m9.figshare.12095103.v1
title: [Comportamento de vacas da raça Holandesa em ordenha robótica (Behaviour of holstein cows in robotic milking)]

description: ABSTRACT The aim of this study was to assess the ingestive behavior of concentrate and milking of dairy cows in automatic milking system (AMS) according to parity. The experiment was conducted from March to June 2014, in Castro, PR, with Holstein cows housed in a free stall, milked automatically, and classified according to the lactation order (1, 2 and +3 lactations). Data were extracted from the management software, considering the activities of one day a month (24 hours) for four months, the day after the official milk production control. The data were analyzed by multivariate analysis (factorial analysis, canonical and cluster), using the statistical package SAS. The ingestive behavior of concentrate influenced the entire activity of the cows in the AMS, being a fundamental factor in the performance of animals in this system. Parity did not influence the milking behavior, only the ingestive behavior, due to the social dominance of multiparous cows. High-yielding cows had a more aggressive ingestive behavior. It was concluded that parity influenced the ingestive behavior of concentrate, but does not interfere in milking behavior in cows with higher parity. In the AMS, primiparous should be managed in a specific group.
DOI: 10.6084/m9.figshare.12095076
title: Synergistic effect of sertraline and disulfiram against multidrug resistant bacteria as a new alternative to drug repositioning

description: The repositioning of approved drugs is atopic of interest for the academy and the pharmaceutical industry. The synergistic combination of these drugs can be successful in the treatment of infections caused by resistant bacteria. This study aimed to assess the in vitro synergistic antibacterial activity of sertraline and disulfiram and their interaction with ciprofloxacin and sulfamethoxazole/trimethoprim. We determined the minimum inhibitory concentration, the minimum bactericidal concentration and the fractional inhibitory concentration index. Eighteen bacterial strains were used, being nine American Type Culture Collection reference strains and nine multidrug resistant clinical isolates. Synergy was detected between sertraline and disulfiram against a strain of Staphylococcus aureusATCC 25923 and a clinical isolate of S. aureus. When associated to sulfamethoxazole/trimethoprim and ciprofloxacin, sertraline and disulfiram showed eight synergistic events, which occurred against three different standard strains and two multidrug resistant clinical isolates. When the minimum bactericidal concentration was determined, the bactericidal activity of sertraline was enhanced with disulfiram. Our results suggest that these drugs, widely used to treat depression and chronic alcoholism, have antibacterial potential individually, in association, and combined with antimicrobials, what makes their repositioning a promising therapeutic alternative for the effective treatment of infections caused by multidrug resistant bacteria.
DOI: 10.6084/m9.figshare.12095079
title: Study of the rheology of cement pastes containing ceramic brick wastes end metakaolin

description: ABSTRACT The construction industry has sought the use of sustainable solutions, one of which is the incorporation of waste as building materials. For this, studies have been developed to analyze the viability of the incorporation these residues in mortar and concrete, since these inserts modify the properties of the materials both in the hardened and fresh state. The analysis of materials such as pastes, mortars or concretes in their fresh state is directly linked to the study of a simulation of the requests that they may suffer during their mixing, transportation and application. The constituent materials and the water / binder ratio have a fundamental role in the properties of the pastes. Characteristics of the materials such as the fineness of the binder, the shape of the particle and the mineralogical origin can directly affect its workability. For the understanding of the rheological behavior of cement pastes in the fresh state, several techniques can be used such as flow and oscillation rheometry, the mini-cone spreading method, Marsh funnel flow, Squeeze flow method and the Vane test. In this work the rheological behavior of different cementitious pastes prepared with Portland cement CP V-ARI RS and addition of metakaolin (MK) end ceramic brick wastes (CBW) was studied. The pastes were analyzed for different hydration times and water/binder ratios. The experiment was carried out through measurements of rheological parameters such as flow stress and viscosity, using a parallel plate rotational rheometer. The results showed that the CBW caused a decrease in the initial flow stress when compared to the use of MK, which may contribute to a mixture with easier handling, that is, less viscous.
DOI: 10.6084/m9.figshare.12095082
title: Coconut fiber/LDPE composites: effect of surface treatment of coconut fibers to produced green composites

description: ABSTRACT The development of polymer composites reinforced with natural fibers have gained attention as alternative technology for the processing of new material that provide a lower environmental impact, associated with lower density, biodegradability and interesting mechanical properties. Natural fibers that come from the green coconut have higher stiffness and mechanical resistance when compared with other natural fibers, considering its chemical composition. Although, natural fibers show a weak interaction with the polymer matrix, due to its hydrophilicity when compared to the matrix, hydrophobic. In this work, coconut fibers (CF) were chemically treated by alkalization with sodium hydroxide (NaOH) and mechanically treated by ultrasound in aqueous media. Low-density polyethylene (LDPE)/CF composites were prepared with different contents ofcoconut fiber (5 and 10 wt%), in the molten state using a homogenizer with high rotation (DRAIS) and stamping for the preparation of the specimens. The treated fibers were characterized by scanning electron microscopy (SEM) and the LDPE/FC composites were characterized according to the thermal properties (differential scanning calorimetry - DSC), mechanical properties (tensile tests) and morphology (SEM). From the results obtained, it can be concluded that no significant change was observed with the different treatments for composites with 5 wt% of CF compared to the neat LDPE. The best results of mechanical resistance noticedon composites with 5 wt% of CF when compared with composites with 10 wt% of CF. The ultrasound treatment demonstrated the best performance. The crystallization degree of the neat LDPE was not affected by the presence of the coconut fibers, although there was a good interaction and adhesion between the CF and thepolymer matrix.
DOI: 10.6084/m9.figshare.12095085.v1
title: Evaluation of mechanical properties of grouts substituting the natural coarse aggregate for ceramic civil construction waste

description: ABSTRACT The lack of control regarding waste generation is a problem still faced by the construction industry, whereas its inputs could be used in the production of new cementitious composites, maintaining the quality, performance and sustainability of structures. This study developed grouts through the substitution of natural aggregate for residues of crushed ceramic bricks, evaluating its fresh state and mechanical properties. The samples displayed loss of workability and initial slump in fresh state, besides loss of compressive strength, elastic modulus, total water absorption and capillary water absorption in hardened state. In addition, composites with grog presented less consistency in fresh state when compared to the reference sample. The differences were even greater over time. As for the hardened state, the compressive strength of the samples was similaramong them at both ages, and all results remained above 14 MPa at 28 days, as required by ASTM C476, hence being characterized as structural grouts for masonry. For the elastic modulus test, the results were higher for samples with lower amounts of waste due to less internal voids and higher volume of natural aggregates. The substitution of natural aggregate for civil construction waste (CCW) in the mixtures increased void ratio and water absorption, while causing the lowest specific gravities of the research. Overall, the sample that presented the most satisfactory values was CCW 25%, showing that it is possible to obtain benefits from waste produced in factories and buildings, even for higher replacement levels, occasionally
DOI: 10.6084/m9.figshare.12095076.v1
title: Synergistic effect of sertraline and disulfiram against multidrug resistant bacteria as a new alternative to drug repositioning

description: The repositioning of approved drugs is atopic of interest for the academy and the pharmaceutical industry. The synergistic combination of these drugs can be successful in the treatment of infections caused by resistant bacteria. This study aimed to assess the in vitro synergistic antibacterial activity of sertraline and disulfiram and their interaction with ciprofloxacin and sulfamethoxazole/trimethoprim. We determined the minimum inhibitory concentration, the minimum bactericidal concentration and the fractional inhibitory concentration index. Eighteen bacterial strains were used, being nine American Type Culture Collection reference strains and nine multidrug resistant clinical isolates. Synergy was detected between sertraline and disulfiram against a strain of Staphylococcus aureusATCC 25923 and a clinical isolate of S. aureus. When associated to sulfamethoxazole/trimethoprim and ciprofloxacin, sertraline and disulfiram showed eight synergistic events, which occurred against three different standard strains and two multidrug resistant clinical isolates. When the minimum bactericidal concentration was determined, the bactericidal activity of sertraline was enhanced with disulfiram. Our results suggest that these drugs, widely used to treat depression and chronic alcoholism, have antibacterial potential individually, in association, and combined with antimicrobials, what makes their repositioning a promising therapeutic alternative for the effective treatment of infections caused by multidrug resistant bacteria.
DOI: 10.6084/m9.figshare.12095082.v1
title: Coconut fiber/LDPE composites: effect of surface treatment of coconut fibers to produced green composites

description: ABSTRACT The development of polymer composites reinforced with natural fibers have gained attention as alternative technology for the processing of new material that provide a lower environmental impact, associated with lower density, biodegradability and interesting mechanical properties. Natural fibers that come from the green coconut have higher stiffness and mechanical resistance when compared with other natural fibers, considering its chemical composition. Although, natural fibers show a weak interaction with the polymer matrix, due to its hydrophilicity when compared to the matrix, hydrophobic. In this work, coconut fibers (CF) were chemically treated by alkalization with sodium hydroxide (NaOH) and mechanically treated by ultrasound in aqueous media. Low-density polyethylene (LDPE)/CF composites were prepared with different contents ofcoconut fiber (5 and 10 wt%), in the molten state using a homogenizer with high rotation (DRAIS) and stamping for the preparation of the specimens. The treated fibers were characterized by scanning electron microscopy (SEM) and the LDPE/FC composites were characterized according to the thermal properties (differential scanning calorimetry - DSC), mechanical properties (tensile tests) and morphology (SEM). From the results obtained, it can be concluded that no significant change was observed with the different treatments for composites with 5 wt% of CF compared to the neat LDPE. The best results of mechanical resistance noticedon composites with 5 wt% of CF when compared with composites with 10 wt% of CF. The ultrasound treatment demonstrated the best performance. The crystallization degree of the neat LDPE was not affected by the presence of the coconut fibers, although there was a good interaction and adhesion between the CF and thepolymer matrix.
DOI: 10.6084/m9.figshare.12095070
title: [Standardization of ultrasound examination of the prepuce and free end of the bovine penis]

description: ABSTRACT Ultrasonography is a noninvasive complementary exam that is still rarely used in the preputial evaluation and without detailed descriptions of the bovine free end of the penis. The purpose of this study was to standardize preputial ultrasonography in one-year-old healthy Nelore cattle, describing the main acoustic windows, the viability of using contrast in the preputial cavity and the best positioning of the animal for performing the ultrasound examination. The scanning was performed with the animals in standing and decubitus position. Five acoustic windows were determined from the preputial ostium to the preputial fornix, at the free end of the penis. The scans were performed in longitudinal, transverse and dorsal planes, before and after infiltration of 0.9% saline solution into the preputial cavity. As conclusions, the ultrasound examination is able to identify the internal layer and the free part of the penis in all proposed planes and acoustic windows. The best landmark is the identification of the glans. Furthermore, standing positioning is the most appropriate to perform the exam and the use of contrast is recommended for topographic delimitation of the structures.
DOI: 10.6084/m9.figshare.12095079.v1
title: Study of the rheology of cement pastes containing ceramic brick wastes end metakaolin

description: ABSTRACT The construction industry has sought the use of sustainable solutions, one of which is the incorporation of waste as building materials. For this, studies have been developed to analyze the viability of the incorporation these residues in mortar and concrete, since these inserts modify the properties of the materials both in the hardened and fresh state. The analysis of materials such as pastes, mortars or concretes in their fresh state is directly linked to the study of a simulation of the requests that they may suffer during their mixing, transportation and application. The constituent materials and the water / binder ratio have a fundamental role in the properties of the pastes. Characteristics of the materials such as the fineness of the binder, the shape of the particle and the mineralogical origin can directly affect its workability. For the understanding of the rheological behavior of cement pastes in the fresh state, several techniques can be used such as flow and oscillation rheometry, the mini-cone spreading method, Marsh funnel flow, Squeeze flow method and the Vane test. In this work the rheological behavior of different cementitious pastes prepared with Portland cement CP V-ARI RS and addition of metakaolin (MK) end ceramic brick wastes (CBW) was studied. The pastes were analyzed for different hydration times and water/binder ratios. The experiment was carried out through measurements of rheological parameters such as flow stress and viscosity, using a parallel plate rotational rheometer. The results showed that the CBW caused a decrease in the initial flow stress when compared to the use of MK, which may contribute to a mixture with easier handling, that is, less viscous.
DOI: 10.6084/m9.figshare.12095070.v1
title: [Standardization of ultrasound examination of the prepuce and free end of the bovine penis]

description: ABSTRACT Ultrasonography is a noninvasive complementary exam that is still rarely used in the preputial evaluation and without detailed descriptions of the bovine free end of the penis. The purpose of this study was to standardize preputial ultrasonography in one-year-old healthy Nelore cattle, describing the main acoustic windows, the viability of using contrast in the preputial cavity and the best positioning of the animal for performing the ultrasound examination. The scanning was performed with the animals in standing and decubitus position. Five acoustic windows were determined from the preputial ostium to the preputial fornix, at the free end of the penis. The scans were performed in longitudinal, transverse and dorsal planes, before and after infiltration of 0.9% saline solution into the preputial cavity. As conclusions, the ultrasound examination is able to identify the internal layer and the free part of the penis in all proposed planes and acoustic windows. The best landmark is the identification of the glans. Furthermore, standing positioning is the most appropriate to perform the exam and the use of contrast is recommended for topographic delimitation of the structures.
DOI: 10.6084/m9.figshare.12095052
title: Antisepsys and profilatic antimicrobial therapy in prevention of surgical site infection of horses

description: ABSTRACT The efficacy of an antisepsis protocol comprising chlorhexidine gluconate and ethyl alcohol in combination with prophylactic antimicrobial therapy in controlling surgical site infection in horses was studied. To that purpose, seven mixed breed horses received potassium penicillin and gentamicin at least 30 minutes prior to surgery. The surgical site was scrubbed with chlorhexidine gluconate and rinsed with ethyl alcohol. Samples were collected at four time points: (A) - before and (B) - immediately following shaving of the hair coat, (C) - at the end of antisepsis procedures, and (D) - at the end of the surgical procedure. Duration of surgery was recorded. Samples were cultured in three different culture mediums: Mitis Salivarus (Streptococcus sp.), Staphylococcus 110 (Staphylococcus sp.), and Mac Conkey (Enterobacteria). A high level of bacterial growth was observed in all culture mediums at (A) and (B), with no bacterial growth in (C). Staphylococcus sp. growth was observed in (D) in a single patient whose surgical procedure lasted for 120 minutes. Shaving of the hair coat reduced microbial flora on the surface of the skin. Antisepsis in combination with prophylactic antimicrobial therapy was effective in controlling surgical site infection in elective procedures with an average duration of 90 minutes.
DOI: 10.6084/m9.figshare.12095055
title: Investigation of TPP-Chitosomes particles structure and stability as encapsulating agent of cholecalciferol

description: Abstract Tripolyphosphate (TPP)-chitosomes were produced aiming at the encapsulation and conservation of vitamin D3. This hybrid system is made of liposomes, vesicles consisting of phospholipid bilayers, surrounded by chitosan wall ionic-crosslinked with TPP. Chitosan concentrations (2 and 4 mg mL-1) were tested and the vitamin stability in aqueous dispersions monitored for 49 days. The results confim that D3 remained stable throughout the analyzed period (49 days), whereas the non-encapsulated vitamin totally degrades after the second week of storage. The particle diameters ranged from 0.1 to 5 μm with good colloidal stability (+22 to +48 mV), and encapsulation efficiency of 97%. Thermal stability was also improved when using the TPP-chitosomes. The protection performed was attributed to the stable interactions conferred by the phospholipids crosslinking with the chitosan amino groups and a formation of a net of hydrogen bonds established amongst the hydroxyl groups of the interacting compounds as revealed by infrared spectroscopy.