cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.29413487.v1
title: Excessive autophagic degradation of MYLK3 causes sunitinib-induced cardiotoxicity

description: Sunitinib is a receptor tyrosine kinase inhibitor used for the treatment of renal cell carcinoma and imatinib-resistant gastrointestinal stromal tumors. Clinical data have shown that patients receiving sunitinib develop reduced cardiac function, arrhythmia and heart failure, thereby largely limiting its clinical use. However, the molecular mechanisms underlying sunitinib-induced arrhythmogenesis remain unclear. Here, utilizing the human induced pluripotent stem cell-derived cardiomyocyte (iPSC-CM) model, we found that sunitinib caused a variety of deleterious phenotypes, including cardiomyocyte death, sarcomeric disorganization, irregular Ca<sup>2+</sup> transients, impaired ATP2A2a/SERCA2a (ATPase sarcoplasmic/endoplasmic reticulum Ca<sup>2+</sup> transporting 2a) activity, arrhythmia, and excessive macroautophagy/autophagy. Mechanistically, SQSTM1/p62 (sequestosome 1) interacts with MYLK3 (myosin light chain kinase 3) and drives excessive autophagic degradation of MYLK3 in sunitinib-treated iPSC-CMs. Downregulation of MYLK3 suppresses the phosphorylation of CAMK2/CAMKII (calcium/calmodulin dependent protein kinase II), thereby reducing the phosphorylation level of its downstream substrate PLN (phospholamban), leading to impaired ATP2A2a/SERCA2a activity and subsequent Ca<sup>2+</sup> dyshomeostasis and arrhythmia. Moreover, pharmacological intervention of the cardiac myosin activator omecamtiv mecarbil (OM) or overexpression of MYLK3 significantly restored the expression of MYLK3 and reversed pathogenic phenotypes in sunitinib-treated iPSC-CMs. Nanoparticle delivery of OM effectively prevented sunitinib-induced cardiac dysfunction in mice. Our findings suggest that sunitinib-induced MYLK3 degradation causes the inhibition of the CAMK2-PLN-ATP2A2a signaling pathway and leads to sunitinib-induced arrhythmogenesis, and that MYLK3 can act as a novel cardioprotective target for sunitinib-induced cardiotoxicity. <b>Abbreviation</b>: ACTN:actinin alpha;APD:action potential duration; ATG:autophagy related;ATP2A2a/SERCA2a:ATPase sarcoplasmic/endoplasmicreticulum Ca2+ transporting 2a;BafA1:bafilomycin A<sub>1</sub>;Caff: caffine; CAMK2/CAMKII:calcium/calmodulin dependent protein kinase II;CASP3:caspase 3;CQ, chloroquine;DADs:delayed afterdepolarizations; EAD:early afterdepolarization; ECG: electrocardiogram; EF: ejectionfraction; FS: fractional shortening; iPSC:inducedpluripotent stem cell;iPSC-CM: inducedpluripotent stem-cell-derived cardiomyocyte;ISO: isoprenaline; LVIDs: left ventricular end systolic diameter;LVIDd: left ventricular end diastolic diameter;MAP1LC3/LC3:microtubuleassociatedprotein 1 light chain 3;MYL2v/MLC2v:myosin light chain 2 v;MYLK3:myosin light chain kinase 3;OE: overexpression; OM:omecamtiv mecarbil; PLN: phospholamban;SIC:sunitinib-induced cardiotoxicity; SR:sarcoplasmic reticulum; TUNEL:TdT-mediated dUTP nick end labeling.
DOI: 10.6084/m9.figshare.30267334
title: Aging-rewired metabolic cues promote autophagy and senescence via DRAM1

description: Being a major contributor to cell senescence and aging, DNA damage activates macroautophagy/autophagy, but how this process is affected by aging-rewired metabolism in normal biological systems remains to be explored. Here in cultured human umbilical cord-derived mesenchymal stem cells (HsMSCs) and the mouse liver that accumulate DNA damage during aging, we found an elevation of DRAM1 (DNA damage regulated autophagy modulator 1) and DRAM1-mediated pro-senescent autophagy (DMPA). Confirming that DRAM1 activated AMPK, we sought DMPA-associated metabolic features and noted substantial enrichment of N-acetylhistamine (N-AcHA) and phosphatidylethanolamine (PE) products in the aging HsMSCs and mouse liver. Elevating DNA damage and senescence, N-AcHA supplements were sufficient to upregulate DRAM1 and DMPA in primary hepatocytes from young mice but not even in pre-senescent HsMSCs, hence reflecting the differential tolerance of these cell models toward cytotoxic metabolic cues. The effects of N-AcHA were further verified in mouse aging and post-hepatectomy liver regeneration models. In contrast, accumulating cellular PE contents via ethanolamine supplements augmented autophagy but not DNA damage and senescence despite tending to induce DRAM1. Combined treatments with N-AcHA and ethanolamine were sufficient to trigger DMPA in HsMSCs. Despite their differential cellular responses toward N-AcHA and ethanolamine supplements, in primary HsMSCs and mouse hepatocytes DMPA did not notably downregulate SQSTM1/p62 proteins, which differed from general macroautophagy and may constitutively support the fusion of SQSTM1-modified cargo-containing autophagosomes with lysosomes. Overall, this study reveals DMPA-promoting metabolic and molecular features. Thus, targeting certain metabolic pathways and DMPA may promote DNA repair and delay senescence/aging. <b>Abbreviations:</b> ATM: ATM serine/threonine kinase; ATG5: autophagy related 5; ACTB: actin beta; BaFA1: bafilomycin A<sub>1</sub>; CDKN1A/p21: cyclin dependent kinase inhibitor 1A; DDR: DNA damage response; DEGs: differentially expressed genes; DRAM1: DNA damage regulated autophagy modulator 1; DMPA: DRAM1-mediated pro-senescent autophagy; DPMPs: differentially presented metabolic products; ETO: etoposide; Eth: ethanolamine; GL: glycerolipids; GP: glycerophospholipids; γ-H2AX: phosphorylated H2A.X variant histone; GAPDH: glyceraldehyde-3-phosphate dehydrogenase; HsMSC: human mesenchymal stem cell; MAP1LC3/LC3: microtubule associated protein 1 light chain 3; MSA: methanesulfonic acid; N-AcHA: N-acetylhistamine; PE: phosphatidylethanolamine; PHx: partial hepatectomy; PCYT2: phosphate cytidyltransferase 2, ethanolamine; SASP: senescence-associated secretory phenotype; SA-GLB1/β-gal: senescence-associated galactosidase beta 1; SQSTM1/p62: sequestosome 1; TAF: telomere-associated foci; TP53/p53: tumor protein p53.
DOI: 10.6084/m9.figshare.30267334.v1
title: Aging-rewired metabolic cues promote autophagy and senescence via DRAM1

description: Being a major contributor to cell senescence and aging, DNA damage activates macroautophagy/autophagy, but how this process is affected by aging-rewired metabolism in normal biological systems remains to be explored. Here in cultured human umbilical cord-derived mesenchymal stem cells (HsMSCs) and the mouse liver that accumulate DNA damage during aging, we found an elevation of DRAM1 (DNA damage regulated autophagy modulator 1) and DRAM1-mediated pro-senescent autophagy (DMPA). Confirming that DRAM1 activated AMPK, we sought DMPA-associated metabolic features and noted substantial enrichment of N-acetylhistamine (N-AcHA) and phosphatidylethanolamine (PE) products in the aging HsMSCs and mouse liver. Elevating DNA damage and senescence, N-AcHA supplements were sufficient to upregulate DRAM1 and DMPA in primary hepatocytes from young mice but not even in pre-senescent HsMSCs, hence reflecting the differential tolerance of these cell models toward cytotoxic metabolic cues. The effects of N-AcHA were further verified in mouse aging and post-hepatectomy liver regeneration models. In contrast, accumulating cellular PE contents via ethanolamine supplements augmented autophagy but not DNA damage and senescence despite tending to induce DRAM1. Combined treatments with N-AcHA and ethanolamine were sufficient to trigger DMPA in HsMSCs. Despite their differential cellular responses toward N-AcHA and ethanolamine supplements, in primary HsMSCs and mouse hepatocytes DMPA did not notably downregulate SQSTM1/p62 proteins, which differed from general macroautophagy and may constitutively support the fusion of SQSTM1-modified cargo-containing autophagosomes with lysosomes. Overall, this study reveals DMPA-promoting metabolic and molecular features. Thus, targeting certain metabolic pathways and DMPA may promote DNA repair and delay senescence/aging. <b>Abbreviations:</b> ATM: ATM serine/threonine kinase; ATG5: autophagy related 5; ACTB: actin beta; BaFA1: bafilomycin A<sub>1</sub>; CDKN1A/p21: cyclin dependent kinase inhibitor 1A; DDR: DNA damage response; DEGs: differentially expressed genes; DRAM1: DNA damage regulated autophagy modulator 1; DMPA: DRAM1-mediated pro-senescent autophagy; DPMPs: differentially presented metabolic products; ETO: etoposide; Eth: ethanolamine; GL: glycerolipids; GP: glycerophospholipids; γ-H2AX: phosphorylated H2A.X variant histone; GAPDH: glyceraldehyde-3-phosphate dehydrogenase; HsMSC: human mesenchymal stem cell; MAP1LC3/LC3: microtubule associated protein 1 light chain 3; MSA: methanesulfonic acid; N-AcHA: N-acetylhistamine; PE: phosphatidylethanolamine; PHx: partial hepatectomy; PCYT2: phosphate cytidyltransferase 2, ethanolamine; SASP: senescence-associated secretory phenotype; SA-GLB1/β-gal: senescence-associated galactosidase beta 1; SQSTM1/p62: sequestosome 1; TAF: telomere-associated foci; TP53/p53: tumor protein p53.
DOI: 10.15468/dl.3crfzb
title: Occurrence Download

description: A dataset containing 216243 species occurrences available in GBIF matching the query:
{
 "DatasetKey" : [
 "is Déterminations et observations du Forum \"Le Monde des Insectes\" (LMDI)-Données photographiques validées de la galerie du forum \"Le Monde des Insectes\""
 ]
}

 The dataset includes 216243 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0019984-250402121839773/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.zsgwvg
title: Occurrence Download

description: A dataset containing 215881 species occurrences available in GBIF matching the query:
{
 "DatasetKey" : [
 "is Oregon State University Vascular Plant Collection"
 ]
}

 The dataset includes 215881 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0019985-250402121839773/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.b3r8jw
title: Occurrence Download

description: A dataset containing 22965655 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is Colombia",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "IucnRedListCategory is LC",
 "OccurrenceStatus is Present"
 ]
}

 The dataset includes 22965655 records from 2455 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0019980-250402121839773/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.48597/rxfh-j8cr
title: Measurement of Nitrogen oxides at Jungfraujoch

description: Measurement of Nitrogen oxides at Jungfraujoch
DOI: 10.15468/dl.twzt6h
title: Occurrence Download

description: A dataset containing 1062 species occurrences available in GBIF matching the query:
{
 "DatasetKey" : [
 "is FIOCRUZ | Phlebotomine sand flies (Diptera, Psychodidae) of the world"
 ]
}

 The dataset includes 1062 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0002995-250214102907787/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.9bxxff
title: Occurrence Download

description: A dataset containing 28 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Bombus consobrinus wittenburgi Vogt, 1911",
 "Country is Japan",
 "HasGeospatialIssue is false",
 "HasCoordinate is true",
 "OccurrenceStatus is Present",
 "Year is greater than or equal to 1900"
 ]
}

 The dataset includes 28 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0002997-250214102907787/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.r7964t
title: Occurrence Download

description: A dataset containing 2 species occurrences available in GBIF matching the query:
{
 "and" : [
 "HasCoordinate is true",
 "TaxonKey is Penicillium cosmopolitanum Houbraken, Frisvad & Samson"
 ]
}

 The dataset includes 2 records from 2 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0002996-250214102907787/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.h6yp7j
title: Occurrence Download

description: A dataset containing 23562 species occurrences available in GBIF matching the query:
{
 "DatasetKey" : [
 "is Arctic Species Trend Index (ASTI) : Marine"
 ]
}

 The dataset includes 23562 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0002998-250214102907787/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.6084/m9.figshare.28427711
title: Muscone-specific olfactory protein MjavOBP3 identified as the putative scent-marking pheromone in the Sunda pangolin (Manis javanica)

description: Supplementary data1Supplementary data2Supplementary data3Supplementary data4Supplementary data5Supplementary data6Supplementary data7
DOI: 10.15468/dl.56nmu9
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "HasCoordinate is true",
 "TaxonKey is Podospora pseudopauciseta C.Boucher, T.S.Nguyen & Silar"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0003000-250214102907787/datasets/export for details.
DOI: 10.6084/m9.figshare.28429730
title: in vitro digestion study on four functional soups, analyzing their bioactivity at different digestion stages compared to undigested samples

description: We conducted an in vitro digestion study on four functional soups, analyzing their bioactivity at different digestion stages compared to undigested samples. analyses included:<b>Anticholinesterase inhibition</b> – Evaluating potential neuroprotective effects, possibly linked to anti-Alzheimer's activity.<b>ABTS & DPPH assays</b> – Measuring antioxidant capacity.<b>Anti-GR (Glutathione Reductase) & Anti-GPX (Glutathione Peroxidase) activity</b> – Assessing redox balance and potential protective effects against oxidative stress.<b>SOD (Superoxide Dismutase) activity</b> – Determining the ability to counteract superoxide radicals.
DOI: 10.15468/dl.sst96v
title: Occurrence Download

description: A dataset containing 363 species occurrences available in GBIF matching the query:
{
 "and" : [
 "BasisOfRecord is one of (Human Observation, Observation, Occurrence evidence)",
 "Country is Sri Lanka",
 "TaxonKey is Accipiter trivirgatus (Temminck, 1824)",
 "Year 2000-2025"
 ]
}

 The dataset includes 363 records from 2 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0003001-250214102907787/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.j5455p
title: Occurrence Download

description: A dataset containing 5 species occurrences available in GBIF matching the query:
{
 "and" : [
 "HasCoordinate is true",
 "TaxonKey is Verruconis gallopava (W.B.Cooke) Samerp. & de Hoog"
 ]
}

 The dataset includes 5 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0003003-250214102907787/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.25345/c5qn5zq1z
title: MassIVE MSV000097136 - Automated mass spectrometry-based profiling of multi-glycosylated glycosyl inositol phospho ceramides (GIPC) in barley
title: LC-HRMS based profiling of glycosyl inositol phospho ceramides (GIPC) in barley at different development stages and after heat-stress application.
DOI: 10.15468/dl.m5a568
title: Occurrence Download

description: A dataset containing 663738 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Ailanthus altissima (Mill.) Swingle, Heracleum mantegazzianum Sommier & Levier, Impatiens glandulifera Royle, Lysichiton americanus Hultén & H.St.John)",
 "HasGeospatialIssue is false",
 "HasCoordinate is true",
 "OccurrenceStatus is Present",
 "BasisOfRecord is one of (Observation, Machine Observation, Human Observation, Occurrence evidence)",
 "Year is greater than or equal to 1990",
 {
 "or" : [
 "CoordinateUncertaintyInMeters is less than 1000",
 "CoordinateUncertaintyInMeters is null"
 ]
 }
 ]
}

 The dataset includes 663738 records from 841 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0002976-250214102907787/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.mtecqz
title: Occurrence Download

description: A dataset listing the 2654 species recorded in GBIF matching the query:
{
 "DatasetKey" : [
 "is Vertebrate Zoology Division - Herpetology, Yale Peabody Museum"
 ]
}

 The dataset's 2654 records were derived from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0002999-250214102907787/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.326mk6
title: Occurrence Download

description: A dataset containing 4 species occurrences available in GBIF matching the query:
{
 "and" : [
 "HasCoordinate is true",
 "TaxonKey is Paracoccidioides lutzii M.M.Teixeira et al."
 ]
}

 The dataset includes 4 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0003005-250214102907787/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.3nuru2
title: Occurrence Download

description: A dataset containing 12728 species occurrences available in GBIF matching the query:
{
 "and" : [
 "HasGeospatialIssue is false",
 "HasCoordinate is true",
 "OccurrenceStatus is Present",
 {
 "not" : {
 "BasisOfRecord" : [
 "is one of (Fossil, Living Specimen, Material sample, Specimen, Material citation)"
 ]
 }
 },
 "TaxonKey is Aepyceros melampus (Lichtenstein, 1812)"
 ]
}

 The dataset includes 12728 records from 18 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0003006-250214102907787/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.5281/zenodo.14882879
title: Global Hourly Seamless Aerosol Optical Depth Dataset (2021) at 0.05°×0.05° Resolution

description: This dataset was producted based on MERRA-2 AOD, MODIS MAIAC AOD, and VIIRS NOAA/SNPP DB/DT AOD products.
DOI: 10.5281/zenodo.14882880
title: Global Hourly Seamless Aerosol Optical Depth Dataset (2021) at 0.05°×0.05° Resolution

description: This dataset was producted based on MERRA-2 AOD, MODIS MAIAC AOD, and VIIRS NOAA/SNPP DB/DT AOD products.
DOI: 10.15468/dl.8enke4
title: Occurrence Download

description: A dataset containing 4626 species occurrences available in GBIF matching the query:
{
 "and" : [
 "HasCoordinate is true",
 "TaxonKey is Ananas comosus (L.) Merr."
 ]
}

 The dataset includes 4626 records from 286 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0003007-250214102907787/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.5281/zenodo.14840331
title: Simulation Data for Decision-Making in Heads-Up Poker Under Uncertainty

description: This dataset contains simulation data generated for academic research. The study models human decision-making under uncertainty, using heads-up Texas Hold'em as a test domain. The dataset includes results from Monte Carlo simulations of poker games, where the players incorporate strategic parameters such as risk appetite, confidence levels, and bluffing tendencies.

The data is structured to facilitate the analysis of decision-making behaviours in incomplete information games and can be used in the study of game theory, artificial intelligence, behavioural economics, and opponent/entity modelling.

The associated README.md provides additional details on how to interpret the data. Please ensure that the simulation data is first unzipped, and note that the README.md file is best viewed in a dedicated Markdown editor or appropriate application due to known preview issues on Zenodo. There is more information in the codebase used for the generation of this data.

This dataset is useful for research in the following areas:  



Game/Decision Theory: Studying decision-making under uncertainty in incomplete information settings.  

Artificial Intelligence (AI): Training AI models for strategic gameplay and opponent modelling.

Behavioural Economics: Analyzing the impact of risk-taking behaviors on long-term outcomes.

Opponent Modelling: Evaluating how players adjust strategies based on past observations.
DOI: 10.5281/zenodo.14840332
title: Simulation Data for Decision-Making in Heads-Up Poker Under Uncertainty

description: This dataset contains simulation data generated for academic research. The study models human decision-making under uncertainty, using heads-up Texas Hold'em as a test domain. The dataset includes results from Monte Carlo simulations of poker games, where the players incorporate strategic parameters such as risk appetite, confidence levels, and bluffing tendencies.

The data is structured to facilitate the analysis of decision-making behaviours in incomplete information games and can be used in the study of game theory, artificial intelligence, behavioural economics, and opponent/entity modelling.

The associated README.md provides additional details on how to interpret the data. There is more information in the codebase used for the generation of this data.

This dataset is useful for research in the following areas:  



Game/Decision Theory: Studying decision-making under uncertainty in incomplete information settings.  

Artificial Intelligence (AI): Training AI models for strategic gameplay and opponent modelling.

Behavioural Economics: Analyzing the impact of risk-taking behaviors on long-term outcomes.

Opponent Modelling: Evaluating how players adjust strategies based on past observations.
DOI: 10.5281/zenodo.14882890
title: Simulation Data for Decision-Making in Heads-Up Poker Under Uncertainty

description: This dataset contains simulation data generated for academic research. The study models human decision-making under uncertainty, using heads-up Texas Hold'em as a test domain. The dataset includes results from Monte Carlo simulations of poker games, where the players incorporate strategic parameters such as risk appetite, confidence levels, and bluffing tendencies.

The data is structured to facilitate the analysis of decision-making behaviours in incomplete information games and can be used in the study of game theory, artificial intelligence, behavioural economics, and opponent/entity modelling.

The associated README.md provides additional details on how to interpret the data. Please ensure that the simulation data is first unzipped, and note that the README.md file is best viewed in a dedicated Markdown editor or appropriate application due to known preview issues on Zenodo. There is more information in the codebase used for the generation of this data.

This dataset is useful for research in the following areas:  



Game/Decision Theory: Studying decision-making under uncertainty in incomplete information settings.  

Artificial Intelligence (AI): Training AI models for strategic gameplay and opponent modelling.

Behavioural Economics: Analyzing the impact of risk-taking behaviors on long-term outcomes.

Opponent Modelling: Evaluating how players adjust strategies based on past observations.