cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.8226818.v1
title: The relationship of flavonoid intake during pregnancy with excess body weight and gestational diabetes mellitus

description: ABSTRACT Objective: To investigate the relationship of flavonoid intake during pregnancy with maternal excessive body weight and gestational diabetes mellitus (GDM). Subjects and methods: A cross-sectional study was conducted among 785 adult women in singleton pregnancies, and data were collected at the time of the oral glucose tolerance test. For the body mass index (BMI) classification according to the gestational age, the criteria of Atalah was used, and the diagnosis of GDM was based on the World Health Organization of 2014. Two 24-hour dietary recalls were obtained, and the usual intake was determined by the Multiple Source Method. Adjusted multinomial logistic regression was used to investigate the relationship of the flavonoids with overweight and obesity, and adjusted non-conditional logistic regression for the relationship of the flavonoids with GDM. Results: The mean (SD) age of the women was 28 (5) years, 32.1% were overweight, 24.6% were obese and 17.7% were diagnosed with GDM. The median (P25, P75) of total flavonoid intake was 50 (31,75) mg/day. Considering the eutrophic women as the reference, the pregnant women with a higher total flavonoid intake [OR 0.62 (95% CI 0.38; 0.96)] and anthocyanidin intake [OR 0.62 (95% CI 0.40; 0.99)] were less likely to be obese when compared to the women with lower intakes. No association of the flavonoids intake with overweight or GDM was found. Conclusion: A very low intake of flavonoids was observed. The data suggest that the intake of foods naturally rich in total flavonoids and anthocyanidin has a beneficial role regarding obesity among pregnant women.
DOI: 10.6084/m9.figshare.8226821.v1
title: Comparative Analysis of Wind Speed Simulated by BRAMS with Observed Data and Reanalysis

description: Abstract Modeling is used as a useful tool in the field of Meteorology. Therefore, the objective is to adjust the BRAMS (Brazilian developments on the Regional Atmospheric Modeling System) by observed data and reanalysis generated by ERA-Interim, in order to validate wind simulations resolved by the model. This information is extremely useful in previous studies in wind farm projects. For verification were chosen three anemometric towers, located in the localities of Damian, Juazeirinho and Teixeira in the state of Paraiba. The comparison is made during the month of October 2010. The results show that the BRAMS model simulated satisfactorily the actual data for the entire study period, obtaining significant correlations of 99% and minor errors in all cases presented.
DOI: 10.6084/m9.figshare.8226815.v1
title: Influence of Sea Surface Temperature in the Event of Squall Lines on the Northern Coast and Northeastern Brazil

description: Abstract This work aimed to verify the possible relationships of sampling points of the sea surface temperature spatially distributed in the tropical Atlantic and the development of squall lines in North northeast coast of Brazil using techniques of generalized linear modeling. For this, we used generalized linear models from the linear regression Poisson and negative binomial, for analysis of the relationship established by modeling was applied ANOVA variance test with significance level of 0.05 probability to determine which independent variables were more significant in modeling. Also the waste generated by the adjustment of the models in order to identify the distribution that best fitted the data were analyzed. All static analysis was performed in R. software Among the 132 pairs of observations, the magnitude of the correlation coefficient of Pearson (r) ranged from 0.06 (p &lt; 0.04) between (LI and TSM5) and 0.88 (p &lt; 0.0001) (TSM2 and TSM5), despite relations TSM and episodes of LI present no linear relationship or perfect positive linear relationship between the observations still rather have the significant statistical point of view. The results obtained by the negative binomial model had lower waste; however, the Poisson model was also significant from a statistical point of view. The points of extraction temperature values of sea surface (TSM2, TSM5 and TSM10) had the highest contributions in explaining the variability of episodes of instability lines in the north-northeastern Brazil.
DOI: 10.6084/m9.figshare.8226806
title: The role of natural products in modern drug discovery.

description: Abstract: The global medicine market is about 1.1 trillion US dollars. About 35 percent of medicines have originated from natural products. Brazil presents the largest biodiversity in the world, with more than 50,000 species of higher plants. However, few innovative products have been developed in Brazil from active constituents derived from the Brazilian biodiversity. Scientific evidences on plants and venoms have been internationally published by Brazilian scientists over the last 4 decades; but few examples of innovative products are commercially available. Few examples include the anti-hypertensive drug captopril first identified in the venom of the Brazilian viper Bothrops jararaca by Professor Sergio Ferreira; and some phytotherapeutic agents such as Acheflan®, Syntocalmy® and Melagrião® produced by standardized plant extracts with scientific proof of safety, efficacy and quality. Still, only Acheflan® and Melagrião® are obtained from native Brazilian plants. Several issues contribute to the lack of innovative products from the Brazilian biodiversity, but in my opinion, the most challenging ones are i) the lack of specific regulations to allow researchers and companies to access biodiversity for the purposes of scientific and technological innovation; and ii) the absence of a long-term government program to support research and innovation in this field.
DOI: 10.6084/m9.figshare.8226812.v1
title: Tolerance of Eucalyptus and Pinus seedlings to exchangeable Aluminium

description: ABSTRACT: Tolerance to acid soil is an important trait of Eucalyptus and Pinus species introduced into commercial forestry plantations in tropical ecosystems. The objective of this study was to evaluate the effect of the exchangeable Al on growth of the seedlings of two species and one hybrid of Eucalyptus and two species of Pinus. We also wanted to identify the role of the root cation exchangeable capacity (CEC) on Al tolerance. The experiment was conducted under controlled conditions in a greenhouse. The soil used was collected from the top layer of a red yellow Oxisol, from the Brazilian savanna region. The treatments consisted of different rates of P and the presence or absence of liming with CaCO3 and MgCO3. The species of Eucalyptus and Pinus showed no growth differences between the treatments. For all species, a higher density of fine roots was found in treatments with lower levels of bases and a higher Al exchangeable concentration. The Pinus species had a higher root CEC than the Eucalyptus species, which had a lower leaf Al concentration. Al concentration in the fine roots was 50 fold greater than in the leaves of all species. Similar to Al, concentrations of Fe, Cu and Zn in the roots were significantly higher than in the leaves in all species. In contrast, higher Mn concentration was found in the leaf tissue. This may lead species of Eucalyptus and Pinus to be more susceptible to Mn than to Al toxicity.
DOI: 10.6084/m9.figshare.8226803
title: Pulp Fibroblast Cell Apoptosis After Application of Hema Dentine Bonding Material with Ethanol and Water Solvent

description: Abstract The most common main materials for dentin bonding for composite resin restoration is 2-hydroxyethyl methacrylate (HEMA). HEMA has beneficial physical and chemical properties, and stable, yet toxic. The addition of ethanol or water, may reduce the toxic effect of HEMA. Ethanol solvent has lower H-bonding capacity compared to water solvent, so it can bind less free radicals from the residual monomer. This study aimed to analyze apoptosis due to dentine bonding application with ethanol and water solvent. Fibroblast culture cells were obtained from extracted third molar, by means of tripsinasion method. The cells were divided into 4 groups as reached confluent: cell culture without treatment as control, cell culture with scaffold chitosan, cell culture with scaffold and polymerized dentin bonding with ethanol or water solvent. Apoptosis observation was conducted using immunohistochemistry method with ethidium bromide acridin orange staining, under fluorescent microscope with 40´ magnification. There was a significant difference among groups (p=0.0001), yet no differences found between different solvent. Apoptosis rate in fibroblast cells culture exposed to HEMA bonding with ethanol solvent was 67%, while the cells exposed to HEMA bonding with water solvent was 44%. The effect of dentin bonding with ethanol solvent and water solvent towards apoptosis rate of pulp fibroblast cells is not different.
DOI: 10.6084/m9.figshare.8226806.v1
title: The role of natural products in modern drug discovery.

description: Abstract: The global medicine market is about 1.1 trillion US dollars. About 35 percent of medicines have originated from natural products. Brazil presents the largest biodiversity in the world, with more than 50,000 species of higher plants. However, few innovative products have been developed in Brazil from active constituents derived from the Brazilian biodiversity. Scientific evidences on plants and venoms have been internationally published by Brazilian scientists over the last 4 decades; but few examples of innovative products are commercially available. Few examples include the anti-hypertensive drug captopril first identified in the venom of the Brazilian viper Bothrops jararaca by Professor Sergio Ferreira; and some phytotherapeutic agents such as Acheflan®, Syntocalmy® and Melagrião® produced by standardized plant extracts with scientific proof of safety, efficacy and quality. Still, only Acheflan® and Melagrião® are obtained from native Brazilian plants. Several issues contribute to the lack of innovative products from the Brazilian biodiversity, but in my opinion, the most challenging ones are i) the lack of specific regulations to allow researchers and companies to access biodiversity for the purposes of scientific and technological innovation; and ii) the absence of a long-term government program to support research and innovation in this field.
DOI: 10.6084/m9.figshare.8226803.v1
title: Pulp Fibroblast Cell Apoptosis After Application of Hema Dentine Bonding Material with Ethanol and Water Solvent

description: Abstract The most common main materials for dentin bonding for composite resin restoration is 2-hydroxyethyl methacrylate (HEMA). HEMA has beneficial physical and chemical properties, and stable, yet toxic. The addition of ethanol or water, may reduce the toxic effect of HEMA. Ethanol solvent has lower H-bonding capacity compared to water solvent, so it can bind less free radicals from the residual monomer. This study aimed to analyze apoptosis due to dentine bonding application with ethanol and water solvent. Fibroblast culture cells were obtained from extracted third molar, by means of tripsinasion method. The cells were divided into 4 groups as reached confluent: cell culture without treatment as control, cell culture with scaffold chitosan, cell culture with scaffold and polymerized dentin bonding with ethanol or water solvent. Apoptosis observation was conducted using immunohistochemistry method with ethidium bromide acridin orange staining, under fluorescent microscope with 40´ magnification. There was a significant difference among groups (p=0.0001), yet no differences found between different solvent. Apoptosis rate in fibroblast cells culture exposed to HEMA bonding with ethanol solvent was 67%, while the cells exposed to HEMA bonding with water solvent was 44%. The effect of dentin bonding with ethanol solvent and water solvent towards apoptosis rate of pulp fibroblast cells is not different.
DOI: 10.6084/m9.figshare.8226791
title: The insect reservoir of biodiversity for viruses and for antiviral mechanisms

description: Abstract: Insects are the most diverse group of animals. They can be infected by an extraordinary diversity of viruses. Among them, arthropod-borne viruses (arboviruses) can be transmitted to humans. High-throughput sequencing of small RNAs from insects provides insight into their virome, which may help understand the dynamics of vector borne infectious diseases. Furthermore, investigating the mechanisms that restrict viral infections in insects points to genetic innovations that may inspire novel antiviral strategies.
DOI: 10.6084/m9.figshare.8226794
title: Fishes of the Amazon: diversity and beyond

description: Abstract: The Amazon basin houses a particular group of freshwater organisms, whose study tells the geological history of the region, how biological diversity was shaped, how it is maintained, and what it hides. The fish of the Amazon is represented by more than 3,000 known species distributed from the basal groups up to the more specialized ones. This species richness hides a diversity of adaptations that are dispersed at all levels of the biological organization. In this summary of the conference delivered at the Brazil-France Bilateral Symposium, held in Manaus in 2018, we describe two aspects of the hidden world of adaptive diversity: adaptations to changes in dissolved oxygen and the abilities of the Rio Negro fish to face acidic and ion-poor waters of their habitats. Also, we present the vulnerability of Amazonian fish to ongoing climate changes. Then, very briefly, we call attention to the many hidden biological processes that allow these fish species to survive their environments, much of which is unknown. Indeed, however, they are intricately related to men, either by responding to environmental disturbances that we have caused, or by containing information that contributes to improving the quality of the environment in which we live.
DOI: 10.6084/m9.figshare.8226797
title: The effect of pseudoexfoliation syndrome on choroidal thickness in open-angle glaucoma

description: ABSTRACT Purpose: To investigate the effect of pseudoex foliation syndrome on choroidal thickness as compared with healthy individuals and subjects with primary open-angle glaucoma. Methods: This prospective, randomized study included 30 primary open angle glaucoma patients and 30 pseudoexfoliation glaucoma patients with similar demographic characteristics and 30 eyes of 30 healthy individuals comprised the control group. Regular optic nerve and macular images were obtained using a Cirrus HD spectral domain optical coherence tomography instrument, along with macular choroidal thickness measurements with enhanced depth imaging mode. Results: Age, sex, and axial length values were similar among the three groups (p&gt;0.05). The primary open angle glaucoma and pseudoexfoliation glaucoma groups had comparable levels of glaucomatous damage. The mean subfoveal choroidal thickness values in the primary open angle glaucoma, pseudoexfoliation glaucoma, and control groups were 271.80 ± 19.96 μm, 241.43 ± 32.47 μm, and 268.03 ± 24.50 μm, respectively. The pseudoexfoliation glaucoma group had the lowest choroidal thickness values of the three groups (p values: pseudoexfoliation-control: 0.001; pseudoexfoliation-primary open angle glaucoma: &lt;0.001, primary open angle glaucoma-control: 0.516, independent samples t-test). Conclusion: The macular choroid was thinner in patients with pseudoexfoliation glaucoma, as compared with both healthy individuals and open-angle glaucoma patients with similar degrees of glaucomatous damage.
DOI: 10.6084/m9.figshare.8226797.v1
title: The effect of pseudoexfoliation syndrome on choroidal thickness in open-angle glaucoma

description: ABSTRACT Purpose: To investigate the effect of pseudoex foliation syndrome on choroidal thickness as compared with healthy individuals and subjects with primary open-angle glaucoma. Methods: This prospective, randomized study included 30 primary open angle glaucoma patients and 30 pseudoexfoliation glaucoma patients with similar demographic characteristics and 30 eyes of 30 healthy individuals comprised the control group. Regular optic nerve and macular images were obtained using a Cirrus HD spectral domain optical coherence tomography instrument, along with macular choroidal thickness measurements with enhanced depth imaging mode. Results: Age, sex, and axial length values were similar among the three groups (p&gt;0.05). The primary open angle glaucoma and pseudoexfoliation glaucoma groups had comparable levels of glaucomatous damage. The mean subfoveal choroidal thickness values in the primary open angle glaucoma, pseudoexfoliation glaucoma, and control groups were 271.80 ± 19.96 μm, 241.43 ± 32.47 μm, and 268.03 ± 24.50 μm, respectively. The pseudoexfoliation glaucoma group had the lowest choroidal thickness values of the three groups (p values: pseudoexfoliation-control: 0.001; pseudoexfoliation-primary open angle glaucoma: &lt;0.001, primary open angle glaucoma-control: 0.516, independent samples t-test). Conclusion: The macular choroid was thinner in patients with pseudoexfoliation glaucoma, as compared with both healthy individuals and open-angle glaucoma patients with similar degrees of glaucomatous damage.
DOI: 10.6084/m9.figshare.8226800
title: Combined effects of water status and iron deficiency chlorosis on grape composition in non-irrigated vineyards

description: ABSTRACT: Although water deficit and iron deficiency chlorosis are common environmental stresses in the Mediterranean area, few data are reported in the literature on their effects on vineyards, when acting simultaneously. The main objective of this research was to study the combined effects of iron deficiency and water status on vigor, yield and fruit composition in rainfed vineyards. Moreover, the investigation aimed to evaluate the feasibility of using foliar chlorophyll content (Chl) and predawn leaf water potential (LWP), measured at veraison, to assess potential quality of grapes in the framework of precision viticulture. For this, 24 non-irrigated ‘Tempranillo’ vineyard subzones were monitored in Ribera del Duero (North-Central Spain) during three consecutive seasons (2011-2013). The analysis of variance and principal component analysis showed that malic acid concentrations of the must were impacted only by Chl, whereas total soluble solids and total acidity were mainly modified by LWP. Both water and iron status reduced yield and berry weight and had additive effects on extractable anthocyanin content in grapes, total polyphenol index and color density of the must. In all seasons, the ratio Chl/LWP had a better predicting value for quality parameters of these grapes than leaf area index, Chl or LWP individually. The present work demonstrates the potential interest of physiological indexes combining water status and foliar chlorosis as indicators of grape phenolic potential in rainfed vineyards affected by iron deficiency.
DOI: 10.6084/m9.figshare.8226791.v1
title: The insect reservoir of biodiversity for viruses and for antiviral mechanisms

description: Abstract: Insects are the most diverse group of animals. They can be infected by an extraordinary diversity of viruses. Among them, arthropod-borne viruses (arboviruses) can be transmitted to humans. High-throughput sequencing of small RNAs from insects provides insight into their virome, which may help understand the dynamics of vector borne infectious diseases. Furthermore, investigating the mechanisms that restrict viral infections in insects points to genetic innovations that may inspire novel antiviral strategies.
DOI: 10.6084/m9.figshare.8226794.v1
title: Fishes of the Amazon: diversity and beyond

description: Abstract: The Amazon basin houses a particular group of freshwater organisms, whose study tells the geological history of the region, how biological diversity was shaped, how it is maintained, and what it hides. The fish of the Amazon is represented by more than 3,000 known species distributed from the basal groups up to the more specialized ones. This species richness hides a diversity of adaptations that are dispersed at all levels of the biological organization. In this summary of the conference delivered at the Brazil-France Bilateral Symposium, held in Manaus in 2018, we describe two aspects of the hidden world of adaptive diversity: adaptations to changes in dissolved oxygen and the abilities of the Rio Negro fish to face acidic and ion-poor waters of their habitats. Also, we present the vulnerability of Amazonian fish to ongoing climate changes. Then, very briefly, we call attention to the many hidden biological processes that allow these fish species to survive their environments, much of which is unknown. Indeed, however, they are intricately related to men, either by responding to environmental disturbances that we have caused, or by containing information that contributes to improving the quality of the environment in which we live.
DOI: 10.6084/m9.figshare.8226785
title: Physiological response of marandu grass seeds exposed to NPK fertilizer

description: ABSTRACT: To facilitate seeding process of forage species, a common practice is to mix seeds with fertilizers in monocropping and intercropping or in implementing integrated livestock production systems. However, in prolonged periods of contact, the fertilizer’s salinity and acidity negatively affect the seeds’ physiological quality. Therefore, this study intends to verify the effect of ten periods (0, 3, 6, 12, 24, 36, 48, 72, 96, and 120 hours) of exposure to granular NPK fertilizer 04-30-16 on the vigor and germination of Urochloa brizantha cv. Marandu seeds. The experiment was conducted in a completely randomized design with three replication. The fertilizer and seed mixture registered a negative effect on seed moisture content, electrical conductivity, emergence, emergence speed index, and seedling and radicle length as the period of exposure to the fertilizer increased from 3 to 120 hours.
DOI: 10.6084/m9.figshare.8226800.v1
title: Combined effects of water status and iron deficiency chlorosis on grape composition in non-irrigated vineyards

description: ABSTRACT: Although water deficit and iron deficiency chlorosis are common environmental stresses in the Mediterranean area, few data are reported in the literature on their effects on vineyards, when acting simultaneously. The main objective of this research was to study the combined effects of iron deficiency and water status on vigor, yield and fruit composition in rainfed vineyards. Moreover, the investigation aimed to evaluate the feasibility of using foliar chlorophyll content (Chl) and predawn leaf water potential (LWP), measured at veraison, to assess potential quality of grapes in the framework of precision viticulture. For this, 24 non-irrigated ‘Tempranillo’ vineyard subzones were monitored in Ribera del Duero (North-Central Spain) during three consecutive seasons (2011-2013). The analysis of variance and principal component analysis showed that malic acid concentrations of the must were impacted only by Chl, whereas total soluble solids and total acidity were mainly modified by LWP. Both water and iron status reduced yield and berry weight and had additive effects on extractable anthocyanin content in grapes, total polyphenol index and color density of the must. In all seasons, the ratio Chl/LWP had a better predicting value for quality parameters of these grapes than leaf area index, Chl or LWP individually. The present work demonstrates the potential interest of physiological indexes combining water status and foliar chlorosis as indicators of grape phenolic potential in rainfed vineyards affected by iron deficiency.