cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.8259989
title: Stent versus Coronary Artery Bypass Surgery in Multi-Vessel and Left Main Coronary Artery Disease: A Meta-Analysis of Randomized Trials with Subgroups Evaluation

description: Abstract Background: Comparison between percutaneous coronary intervention (PCI) using stents and Coronary Artery Bypass Grafting (CABG) remains controversial. Objective: To conduct a systematic review with meta-analysis of PCI using Stents versus CABG in randomized controlled trials. Methods: Electronic databases were searched to identify randomized trials comparing PCI using Stents versus CABG for multi-vessel and unprotected left main coronary artery disease (LMCAD). 15 trials were found and their results were pooled. Differences between trials were considered significant if p &lt; 0.05. Results: In the pooled data (n = 12,781), 30 days mortality and stroke were lower with PCI (1% versus 1.7%, p = 0.01 and 0.6% versus 1.7% p &lt; 0.0001); There was no difference in one and two year mortality (3.3% versus 3.7%, p = 0.25; 6.3% versus 6.0%, p = 0.5). Long term mortality favored CABG (10.6% versus 9.4%, p = 0.04), particularly in trials of DES era (10.1% versus 8.5%, p = 0.01). In diabetics (n = 3,274) long term mortality favored CABG (13.7% versus 10.3%; p &lt; 0.0001). In six trials of LMCAD (n = 4,700) there was no difference in 30 day mortality (0.6%versus 1.1%, p = 0.15), one year mortality (3% versus 3.7%, p = 0.18), and long term mortality (8.1% versus 8.1%) between PCI and CABG; the incidence of stroke was lower with PCI (0.3% versus 1.5%; p &lt; 0.001). Diabetes and a high SYNTAX score were the subgroups that influenced more adversely the results of PCI. Conclusion: Compared with CABG, PCI using Stents showed lower 30 days mortality, higher late mortality and lower incidence of stroke. Diabetes and a high SYNTAX were the subgroups that influenced more adversely the results of PCI.
DOI: 10.6084/m9.figshare.8259995
title: Genetic variability of larvae and fingerlings of Piracanjuba (Brycon orbignyanus)

description: ABSTRACT The objective of this study was to evaluate the genetic variability of Piracanjuba larvae and fingerlings in restocking program. A total of 180 three-day Piracanjuba larvae and 90 three-month-old fish were sampled. Five microsatellite loci were evaluated, which produced 19 alleles. There were no rare alleles or loss of alleles over the period. The observed heterozygosity was higher in larvae compared to fingerlings. There was a deviation in Hardy-Weinberg equilibrium in most loci in both groups. The inbreeding coefficient was positive in both groups, with the average of the fingerlings superior to the larvae. The excess heterozygotes were significant in the Stepwise Mutation Model for the fingerlings, indicating the possibility of a recent bottleneck effect. Despite the adequate genetic variability found, the values of the inbreeding coefficient and the possibility of bottleneck effect in the fingerlings show the need for constant genetic monitoring of these stocks prior to release into the environment.
DOI: 10.6084/m9.figshare.8259995.v1
title: Genetic variability of larvae and fingerlings of Piracanjuba (Brycon orbignyanus)

description: ABSTRACT The objective of this study was to evaluate the genetic variability of Piracanjuba larvae and fingerlings in restocking program. A total of 180 three-day Piracanjuba larvae and 90 three-month-old fish were sampled. Five microsatellite loci were evaluated, which produced 19 alleles. There were no rare alleles or loss of alleles over the period. The observed heterozygosity was higher in larvae compared to fingerlings. There was a deviation in Hardy-Weinberg equilibrium in most loci in both groups. The inbreeding coefficient was positive in both groups, with the average of the fingerlings superior to the larvae. The excess heterozygotes were significant in the Stepwise Mutation Model for the fingerlings, indicating the possibility of a recent bottleneck effect. Despite the adequate genetic variability found, the values of the inbreeding coefficient and the possibility of bottleneck effect in the fingerlings show the need for constant genetic monitoring of these stocks prior to release into the environment.
DOI: 10.6084/m9.figshare.8259989.v1
title: Stent versus Coronary Artery Bypass Surgery in Multi-Vessel and Left Main Coronary Artery Disease: A Meta-Analysis of Randomized Trials with Subgroups Evaluation

description: Abstract Background: Comparison between percutaneous coronary intervention (PCI) using stents and Coronary Artery Bypass Grafting (CABG) remains controversial. Objective: To conduct a systematic review with meta-analysis of PCI using Stents versus CABG in randomized controlled trials. Methods: Electronic databases were searched to identify randomized trials comparing PCI using Stents versus CABG for multi-vessel and unprotected left main coronary artery disease (LMCAD). 15 trials were found and their results were pooled. Differences between trials were considered significant if p &lt; 0.05. Results: In the pooled data (n = 12,781), 30 days mortality and stroke were lower with PCI (1% versus 1.7%, p = 0.01 and 0.6% versus 1.7% p &lt; 0.0001); There was no difference in one and two year mortality (3.3% versus 3.7%, p = 0.25; 6.3% versus 6.0%, p = 0.5). Long term mortality favored CABG (10.6% versus 9.4%, p = 0.04), particularly in trials of DES era (10.1% versus 8.5%, p = 0.01). In diabetics (n = 3,274) long term mortality favored CABG (13.7% versus 10.3%; p &lt; 0.0001). In six trials of LMCAD (n = 4,700) there was no difference in 30 day mortality (0.6%versus 1.1%, p = 0.15), one year mortality (3% versus 3.7%, p = 0.18), and long term mortality (8.1% versus 8.1%) between PCI and CABG; the incidence of stroke was lower with PCI (0.3% versus 1.5%; p &lt; 0.001). Diabetes and a high SYNTAX score were the subgroups that influenced more adversely the results of PCI. Conclusion: Compared with CABG, PCI using Stents showed lower 30 days mortality, higher late mortality and lower incidence of stroke. Diabetes and a high SYNTAX were the subgroups that influenced more adversely the results of PCI.
DOI: 10.6084/m9.figshare.8259992.v1
title: Bivariate Copula-based Linear Mixed-effects Models: An Application to Longitudinal Child Growth Data

description: ABSTRACT Multiple longitudinal outcomes are common in public health research and adequate methods are required when there is interest in the joint evolution of response variables over time. However, the main drawback of joint modeling procedures is the requirement to specify the joint density of all outcomes and their correlation structure, as well as numerical difficulties in statistical inference, when the dimension of these outcomes increases. To overcome such difficulty, we present two procedures to deal with multivariate longitudinal data. We first present an univariate approach, for which linear mixed-effects models are considered for each response variable separately. Then, a novel copula-based modeling is presented, in order to characterize relationships among the response variables. Both methodologies are applied to a real Brazilian data set on child growth.
DOI: 10.6084/m9.figshare.8259986
title: Agronomic performance of Marandu grass treated with plant growth biostimulants in the Amazon biome

description: ABSTRACT The aim was to evaluate the effect of different doses of two biostimulants on the productivity and canopy structure of Urochloa brizantha cv. Marandu grass in the establishment fase. The study was conducted in Universidade Federal Rural da Amazônia, Parauapebas, Pará, Brazil. One module of 35 plots of 25m² were established. A completely randomized experimental design was used, with seven treatments and five replicates. The treatments included a control, 0.5, 1, and 2kg/ha of biostimulant A (BIOST.A); and 0.25, 0.5, and 1L/ha of biostimulant B (BIOST.B). Three collections were performed. The data for application of the two biostimulants were analyzed separately, using the Dummy variable method and regression analysis. The application of 2kg/ha BIOST.A resulted in increases of 842kg/ha in the forage mass. The application of BIOST.B on Marandu grass resulted in a linear increase in stem mass. The application of 2kg/ha BIOST.A in the establishment of Marandu grass result in higher growth rates, forage accumulation, and stem proportion in the canopy.
DOI: 10.6084/m9.figshare.8259980
title: A conjoint analysis to identify the attributes of a device to characteristics recognition in customized food products

description: Abstract The possibility of combining food ingredients at each meal makes it difficult to recognize the characteristics of personalized foods. The use of devices with the Internet of Things (IoT) technologies is an alternative for customers to access customized food information. Five main attributes present in the composition of such devices, aiming ingredients recognition in customized meals, were considered in this study: (A) portability, (B) precision, (C) diet customization, (D) food quality control and (E) price. This study aims to identify the combination of such value generating attributes in a device of food characteristics recognition in customized foods. A fractional factorial design 25-1 was used to display the device characteristics, in the form of scenarios, following the joint analysis method based on choice. For data collection, a survey was carried out with a sample of 303 respondents. Gender moderation and food restriction variables were also analyzed. The results present greater significance for the attributes of measurement accuracy and quality analysis. As contributions, this study presents information for investments targeting in research for the manufacturing of a technological device aiming the recognition of characteristics of a mass-modified food product.
DOI: 10.6084/m9.figshare.8259977
title: The general and volatile properties and the quality of two newly selected Satsuma clones (11/1 İzmir and 30/ İzmir) grown under Mediterranean ecological conditions

description: Abstract The general and volatile properties, and the quality of two new Satsuma clones – 11/1 İzmir and 30/İzmir – selected under a Citrus Bud Wood Selection Program, were compared with Owari Satsuma samples grown under Adana ecological conditions. Gas chromatography, mass spectrometry, flame ionization detection (GC/MS/FID) analysis was used in the identification and quantification of the aromatic compounds, and a sensory profile analysis was performed to complete the general understanding using chemical analysis. The general analysis showed that the clone samples have higher yields, are more intense in skin color and more acidic; however, the total soluble solids and total sugar amount are lower than the Owari Satsuma samples. The terpenes are the major aromatic compound class. Along with other terpenes, there were significant amounts of dl-limonene followed by γ-terpinene, β-elemene, linalool and α-terpineol. The sensory analysis showed that the Owari Satsuma samples are sweeter and riper, with a better floral, spicy-citrus flavor than both clones. Both clones had a lower “Overall liking” rating than the Owari Satsuma samples.
DOI: 10.6084/m9.figshare.8259980.v1
title: A conjoint analysis to identify the attributes of a device to characteristics recognition in customized food products

description: Abstract The possibility of combining food ingredients at each meal makes it difficult to recognize the characteristics of personalized foods. The use of devices with the Internet of Things (IoT) technologies is an alternative for customers to access customized food information. Five main attributes present in the composition of such devices, aiming ingredients recognition in customized meals, were considered in this study: (A) portability, (B) precision, (C) diet customization, (D) food quality control and (E) price. This study aims to identify the combination of such value generating attributes in a device of food characteristics recognition in customized foods. A fractional factorial design 25-1 was used to display the device characteristics, in the form of scenarios, following the joint analysis method based on choice. For data collection, a survey was carried out with a sample of 303 respondents. Gender moderation and food restriction variables were also analyzed. The results present greater significance for the attributes of measurement accuracy and quality analysis. As contributions, this study presents information for investments targeting in research for the manufacturing of a technological device aiming the recognition of characteristics of a mass-modified food product.
DOI: 10.6084/m9.figshare.8259986.v1
title: Agronomic performance of Marandu grass treated with plant growth biostimulants in the Amazon biome

description: ABSTRACT The aim was to evaluate the effect of different doses of two biostimulants on the productivity and canopy structure of Urochloa brizantha cv. Marandu grass in the establishment fase. The study was conducted in Universidade Federal Rural da Amazônia, Parauapebas, Pará, Brazil. One module of 35 plots of 25m² were established. A completely randomized experimental design was used, with seven treatments and five replicates. The treatments included a control, 0.5, 1, and 2kg/ha of biostimulant A (BIOST.A); and 0.25, 0.5, and 1L/ha of biostimulant B (BIOST.B). Three collections were performed. The data for application of the two biostimulants were analyzed separately, using the Dummy variable method and regression analysis. The application of 2kg/ha BIOST.A resulted in increases of 842kg/ha in the forage mass. The application of BIOST.B on Marandu grass resulted in a linear increase in stem mass. The application of 2kg/ha BIOST.A in the establishment of Marandu grass result in higher growth rates, forage accumulation, and stem proportion in the canopy.
DOI: 10.6084/m9.figshare.8259977.v1
title: The general and volatile properties and the quality of two newly selected Satsuma clones (11/1 İzmir and 30/ İzmir) grown under Mediterranean ecological conditions

description: Abstract The general and volatile properties, and the quality of two new Satsuma clones – 11/1 İzmir and 30/İzmir – selected under a Citrus Bud Wood Selection Program, were compared with Owari Satsuma samples grown under Adana ecological conditions. Gas chromatography, mass spectrometry, flame ionization detection (GC/MS/FID) analysis was used in the identification and quantification of the aromatic compounds, and a sensory profile analysis was performed to complete the general understanding using chemical analysis. The general analysis showed that the clone samples have higher yields, are more intense in skin color and more acidic; however, the total soluble solids and total sugar amount are lower than the Owari Satsuma samples. The terpenes are the major aromatic compound class. Along with other terpenes, there were significant amounts of dl-limonene followed by γ-terpinene, β-elemene, linalool and α-terpineol. The sensory analysis showed that the Owari Satsuma samples are sweeter and riper, with a better floral, spicy-citrus flavor than both clones. Both clones had a lower “Overall liking” rating than the Owari Satsuma samples.
DOI: 10.6084/m9.figshare.8259971
title: An Extended Linear Discontinuous Method for One-group Fixed Source Discrete Ordinates Problems with Isotropic Scattering in Slab Geometry

description: ABSTRACT Nowadays, the obtainment of an accurate numerical solution of fixed source discrete ordinates problems is relevant in many areas of engineering and science. In this work, we extend the hybrid Finite Element Spectral Green’s Function method (FEM-SGF), originally developed to solve eigenvalue diffusion problems, for fixed source problems using as a mathematical model, the discrete ordinates formulation in one energy group with isotropic scattering in slab geometry. This new method, Extended Linear Discontinuous Discrete Ordinates (ELD-SN), is based on the use of neutron balance equations and the construction of a hybrid auxiliary equation. This auxiliary equation combines a linear discontinuous approximation and spectral parameters to approximate the neutron angular flux inside the cell. Numerical results for benchmark problems are presented to illustrate the accuracy and computational performance of our methodology. ELD-SN method is free from spatial truncation errors in S 2 quadrature, and generate good results in the other quadrature sets. This method is more accurate than the conventional Diamond Difference (DD) and Linear Discontinuous (LD) methods, but surpassed by the Spectral Green’s Function (SGF) method, for quadrature order greater than two.
DOI: 10.6084/m9.figshare.8259974
title: Humane endpoint in mice by Brazilian researchers in the vaccine sector

description: ABSTRACT The application of a humane endpoint (HE) for mice in vaccine trials and further challenging tasks with lethal samples is necessary to reduce or prevent pain and suffering in these animals, and is a refinement of the 3R policy enforced for animal testing in both national and international scenarios. In order to investigate the application of HE in Brazil, researchers from the vaccine sector have answered a questionnaire about their research profile, their usage of HE and their knowledge of its defining criteria, monitoring of animals, staff training, and euthanasia methods employed. The main results revealed that researchers failed to recognise the very concept of HE as well as when to apply it. In addition, the Institutional Animal Care and Use Committees (IACUCs) failed upon giving their approval to the trials. HE is an important refinament of animal testing policy, and these results highlight the need for a clear pre-established definition of when and how it should be implemented in order to ensure more effective application. Furthermore, it is important to clarify the ethics involved and the commitment of both the research teams and IACUCs to animal welfare.
DOI: 10.6084/m9.figshare.8259965
title: Gluten-free cookies elaborated with buckwheat flour, millet flour and chia seeds

description: Abstract The aim of this study was to obtain an optimized gluten-free cookie formulation using alternative flours. For this, a 22 central composite rotatable design (CCRD), with varying concentrations of millet flour (MF) and chia seeds (CS), on a base of buckwheat flour (BF), was used. Control cookies were elaborated with 100% wheat flour (WF). The cookies were characterized for texture and other physical tests and by scanning electron microscopy of their internal structure. The response surfaces for the quality parameters of the cookies showed that the higher the proportion of MF used in the formulations, the lower the height and the greater the diameter, expansion factor, and hardness of the cookies. The addition of up to 10% CS showed no influence on the responses. The optimum point was defined as that with diameter, expansion factor, thickness, and hardness closer to the control cookie: 7.5% CS, 40% MF, and 52.5% BF. The substitution of wheat flour by buckwheat flour, millet flour, and chia seeds can be considered a suitable alternative for the preparation of gluten-free cookies.
DOI: 10.6084/m9.figshare.8259968
title: Does high stereotypic behavior expression affect productivity measures in sows?

description: ABSTRACT The objective of this study was to evaluate the effects of stereotypic behavior on productivity measures in sows. Frequent expression of stereotypies by pigs has been reported, even when pigs are not maintained in crates. This behavior is only observed in animals kept in captivity and is a wide-range welfare indicator, since it is considered to develop in situations of chronic stress or frustration. When comparing groups of sows showing low or high frequency of stereotypy expression, we found that stereotypic behavior did not affect productivity. Moreover, it did not affect physiological welfare indicators, such as salivary cortisol concentration or glucocorticoids in the placenta. There were no differences in productivity parameters, including weight of sows, weight of piglets, number of piglets weaned, or piglet mortality. Our study was conducted in group-housing pens, where the sows were not confined. Even in this condition, which is considered for increasing welfare, the barren environment did not meet the behavioral and sensory needs of sows, which were naturally selected to perform complex behavioral repertoire and to spend part of their time engaging in exploratory behavior.
DOI: 10.6084/m9.figshare.8259974.v1
title: Humane endpoint in mice by Brazilian researchers in the vaccine sector

description: ABSTRACT The application of a humane endpoint (HE) for mice in vaccine trials and further challenging tasks with lethal samples is necessary to reduce or prevent pain and suffering in these animals, and is a refinement of the 3R policy enforced for animal testing in both national and international scenarios. In order to investigate the application of HE in Brazil, researchers from the vaccine sector have answered a questionnaire about their research profile, their usage of HE and their knowledge of its defining criteria, monitoring of animals, staff training, and euthanasia methods employed. The main results revealed that researchers failed to recognise the very concept of HE as well as when to apply it. In addition, the Institutional Animal Care and Use Committees (IACUCs) failed upon giving their approval to the trials. HE is an important refinament of animal testing policy, and these results highlight the need for a clear pre-established definition of when and how it should be implemented in order to ensure more effective application. Furthermore, it is important to clarify the ethics involved and the commitment of both the research teams and IACUCs to animal welfare.
DOI: 10.6084/m9.figshare.8259965.v1
title: Gluten-free cookies elaborated with buckwheat flour, millet flour and chia seeds

description: Abstract The aim of this study was to obtain an optimized gluten-free cookie formulation using alternative flours. For this, a 22 central composite rotatable design (CCRD), with varying concentrations of millet flour (MF) and chia seeds (CS), on a base of buckwheat flour (BF), was used. Control cookies were elaborated with 100% wheat flour (WF). The cookies were characterized for texture and other physical tests and by scanning electron microscopy of their internal structure. The response surfaces for the quality parameters of the cookies showed that the higher the proportion of MF used in the formulations, the lower the height and the greater the diameter, expansion factor, and hardness of the cookies. The addition of up to 10% CS showed no influence on the responses. The optimum point was defined as that with diameter, expansion factor, thickness, and hardness closer to the control cookie: 7.5% CS, 40% MF, and 52.5% BF. The substitution of wheat flour by buckwheat flour, millet flour, and chia seeds can be considered a suitable alternative for the preparation of gluten-free cookies.