cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.3535/zsh-494-ajk
title: †Obolus Eichwald, 1829

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/c0a-bl4-11v
title: †Murchisonia d'Archiac & Verneuil, 1841

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/q5m-1a7-6ds
title: †Holopea J. Hall, 1847

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/2ck-hmd-dkx
title: †Obolus Eichwald, 1829

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/9xf-099-l2q
title: Littorina littorea (Linnaeus, 1758)

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/ly9-c9w-val
title: †Obolus Eichwald, 1829

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/qzj-pl4-v1v
title: Brachiopoda Duméril, 1805

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/7wx-gn4-r3v
title: Brachiopoda Duméril, 1805

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/czx-0ns-je5
title: Brachiopoda Duméril, 1805

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/fws-123-798
title: Brachiopoda Duméril, 1805

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/mnz-0p2-95x
title: Brachiopoda Duméril, 1805

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/gqb-byv-ekd
title: †Obolus Eichwald, 1829

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/k0k-jat-tp7
title: †Obolus Eichwald, 1829

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.5281/zenodo.15115911
title: AAV-mediated ARSA replacement for the treatment of Metachromatic Leukodystrophy

description: Metachromatic leukodystrophy (MLD) is an autosomal recessive neurodegenerative disorder caused by mutations in the arylsulfatase A (ARSA) gene, resulting in lower sulfatase activity and the toxic accumulation of sulfatides in the central and peripheral nervous system. Children account for 70% of cases and become progressively disabled with death occurring within 10 years of disease onset. Gene therapy approaches to restore ARSA expression via adeno-associated viral vectors (AAV) have been promising but hampered by limited brain biodistribution. We report the development of a novel capsid AAV.GMU01, demonstrating superior biodistribution and transgene expression in the central nervous system of non-human primates (NHPs). Next, we show that AAV.GMU01-ARSA treated MLD mice exhibit persistent, normal levels of sulfatase activity and a concomitant reduction in toxic sulfatides. Treated mice also show a reduction in MLD-associated pathology and auditory dysfunction. Lastly, we demonstrate that treatment with AAV.GMU01-ARSA in NHPs is well-tolerated and results in potentially therapeutic ARSA expression in the brain. In summary, we propose AAV.GMU01-ARSA mediated gene replacement as a clinically viable approach to achieve broad and therapeutic levels of ARSA.
description: RDS file (Seurat object) and h5 files from snRNAseq of mouse brains to assess the biodistribution of novel capsid AAVGMU01 in the mouse brain cells.

Tissue samples were stored at -80°C. For tissue lysis and washing of nuclei, sample sections were added to 1 mL Nuclei PURE lysis buffer (Sigma, NUC-201) and thawed on ice. Samples were then Dounce homogenized with PestleAx20 and PestleBx20 before transfer to a new tube, with the addition of additional lysis buffer. Following incubation on ice for 15 minutes, samples were then filtered using a 30 mM MACS strainer (Fisher, NC0642012), centrifuged at 500xg for 5 minutes at 4°C using a swinging bucket rotor (Sorvall Legend RT, Thermo Fisher), and then pellets were washed with an additional 1 mL cold lysis buffer and incubated on ice for an additional 5 minutes. A 1.8M sucrose buffer was created and 1.8ml was mixed with 1ml of cell suspension. 1ml of sucrose buffer was deposited to ultra centrifuge tube (Fisher, NC9157569) then the cell suspension was layered on top (2.8ml). The suspension was then centrifuged at 30,000xg (17,800 rpm) for 45min at 4C, Rotor SW55ti. Supernatant was then aspirated off, and pellet was resuspended in 1ml of wash buffer (Nuclei Pure storage buffer, Sigma NUC-201) and spun at 500xg for 5 min at 4°C. Supernatant was aspirated and 0.5ml of wash buffer was added for resuspension. 

Libraries were prepared according to 10xGenomics protocol for Chromium Single Cell 3’ Gene Expression V3.1 kit. NovaSeq sequencing was performed according to illumine NovaSeq 6000 protocol. UMI count matrices generated by Cellranger V5.0.0.
DOI: 10.5281/zenodo.15115912
title: AAV-mediated ARSA replacement for the treatment of Metachromatic Leukodystrophy

description: Metachromatic leukodystrophy (MLD) is an autosomal recessive neurodegenerative disorder caused by mutations in the arylsulfatase A (ARSA) gene, resulting in lower sulfatase activity and the toxic accumulation of sulfatides in the central and peripheral nervous system. Children account for 70% of cases and become progressively disabled with death occurring within 10 years of disease onset. Gene therapy approaches to restore ARSA expression via adeno-associated viral vectors (AAV) have been promising but hampered by limited brain biodistribution. We report the development of a novel capsid AAV.GMU01, demonstrating superior biodistribution and transgene expression in the central nervous system of non-human primates (NHPs). Next, we show that AAV.GMU01-ARSA treated MLD mice exhibit persistent, normal levels of sulfatase activity and a concomitant reduction in toxic sulfatides. Treated mice also show a reduction in MLD-associated pathology and auditory dysfunction. Lastly, we demonstrate that treatment with AAV.GMU01-ARSA in NHPs is well-tolerated and results in potentially therapeutic ARSA expression in the brain. In summary, we propose AAV.GMU01-ARSA mediated gene replacement as a clinically viable approach to achieve broad and therapeutic levels of ARSA.
description: RDS file (Seurat object) and h5 files from snRNAseq of mouse brains to assess the biodistribution of novel capsid AAVGMU01 in the mouse brain cells.

Tissue samples were stored at -80°C. For tissue lysis and washing of nuclei, sample sections were added to 1 mL Nuclei PURE lysis buffer (Sigma, NUC-201) and thawed on ice. Samples were then Dounce homogenized with PestleAx20 and PestleBx20 before transfer to a new tube, with the addition of additional lysis buffer. Following incubation on ice for 15 minutes, samples were then filtered using a 30 mM MACS strainer (Fisher, NC0642012), centrifuged at 500xg for 5 minutes at 4°C using a swinging bucket rotor (Sorvall Legend RT, Thermo Fisher), and then pellets were washed with an additional 1 mL cold lysis buffer and incubated on ice for an additional 5 minutes. A 1.8M sucrose buffer was created and 1.8ml was mixed with 1ml of cell suspension. 1ml of sucrose buffer was deposited to ultra centrifuge tube (Fisher, NC9157569) then the cell suspension was layered on top (2.8ml). The suspension was then centrifuged at 30,000xg (17,800 rpm) for 45min at 4C, Rotor SW55ti. Supernatant was then aspirated off, and pellet was resuspended in 1ml of wash buffer (Nuclei Pure storage buffer, Sigma NUC-201) and spun at 500xg for 5 min at 4°C. Supernatant was aspirated and 0.5ml of wash buffer was added for resuspension. 

Libraries were prepared according to 10xGenomics protocol for Chromium Single Cell 3’ Gene Expression V3.1 kit. NovaSeq sequencing was performed according to illumine NovaSeq 6000 protocol. UMI count matrices generated by Cellranger V5.0.0.
DOI: 10.3535/ga6-0jj-65m
title: Platycladus Spach

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/vze-9y9-c3k
title: †Obolus Eichwald, 1829

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/n9w-n1a-ts1
title: Brachiopoda Duméril, 1805

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/qwq-rse-vvs
title: †Obolus Eichwald, 1829

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/21l-0wl-nkz
title: Cerastoderma edule (Linnaeus, 1758)

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/kgz-scd-54z
title: Brachiopoda Duméril, 1805

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/c08-10j-8lt
title: Brachiopoda Duméril, 1805

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/lh8-wnv-4v9
title: †Obolus Eichwald, 1829

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/cww-0wv-gqw
title: Brachiopoda Duméril, 1805

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/152-aej-4tv
title: Cerastoderma edule (Linnaeus, 1758)

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/z5w-yxg-5zj
title: Brachiopoda Duméril, 1805

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/99m-cnb-zl8
title: †Obolus Eichwald, 1829

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/wyf-3n7-vjg
title: Brachiopoda Duméril, 1805

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/86v-0z9-dxk
title: †Obolus Eichwald, 1829

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/r0y-nbx-m2x
title: Brachiopoda Duméril, 1805

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.21949/1530670
title: Air Travel Consumer Report: March 2024 [supporting dataset]

description: These data tables have been extracted from the original 2024 report using ABBYY FineReader PDF Software. This data was exported and cleaned by the NTL Data Services Team. The data is complete and accurate to the original 2000 report. For questions, please contact ntldatacurator@dot.gov National Transportation Library (NTL) Curation Note: This dataset has been curated to CoreTrustSeal's curation level "A. Active Preservation" To find out more information on CoreTrustSeal's curation levels, please consult their "Curation & Preservation Levels" CoreTrustSeal Discussion Paper" (https://doi.org/10.5281/zenodo.11476980). NTL staff last accessed this dataset at its repository URL on 2024-07-31. If, in the future, you have trouble accessing this dataset, please email NTLDataCurator@dot.gov describing your problem. NTL staff will do its best to assist you at that time
description: The Air Travel Consumer Report is a monthly product of the Department of Transportation's Office of Aviation Consumer Protection. The report is designed to assist consumers with information on the quality of services provided by the airlines. 



Data Included in this Report:

Flight Delays: January 2024  

Mishandled Baggage / Wheelchairs and Scooters: January 2024  

Oversales: 4th Quarter 2023  

Consumer Complaints: January 2024  

Customer Service Reports to the Dept. of Homeland Security: January 2024  

Airline Animal Incident Reports: January 2024 



The .xlsx and .xls file types are Microsoft Excel files, which can be opened with Excel, and other free available spreadsheet software, such as OpenRefine. The .csv, Comma Separated Value, file is a simple format that is designed for a database table and supported by many applications. The .csv file is often used for moving tabular data between two different computer programs, due to its open format. The most common software used to open .csv files are Microsoft Excel and RecordEditor, (for more information on .csv files and software, please visit https://www.file-extensions.org/csv-file-extension). The file extension .md is among others related to texts and source codes in Markdown markup language. Markdown is a lightweight markup language, to write using an easy-to-read, easy-to-write plain text format, then convert it to structurally valid XHTML (or HTML) (for more information on .md files and software, please visit https://www.file-extensions.org/md-file-extension). File extension .json is associated to JavaScript Object Notation file format, a lightweight, text-based, language-independent data interchange format. JSON defines a small set of formatting rules for the portable representation of structured data. It is used by various applications as alternative option to XML file format. The data in a json file are stored in simple text file format and the content is viewable in any simple text editor (for more information on .json files and software, please visit https://www.file-extensions.org/json-file-extension).
DOI: 10.3535/131-dsa-qe4
title: †Obolus Eichwald, 1829

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/nq2-lbm-4k2
title: †Obolus Eichwald, 1829

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/4ey-0jn-z3q
title: Brachiopoda Duméril, 1805

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/snp-pzp-a0j
title: †Obolus Eichwald, 1829

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/dag-r09-46e
title: †Obolus Eichwald, 1829

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/q6s-mwq-4v0
title: Brachiopoda Duméril, 1805

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/jaa-a7c-fma
title: Cerastoderma edule (Linnaeus, 1758)

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/tb8-eld-bwy
title: †Obolus Eichwald, 1829

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/efn-tpq-vyk
title: Brachiopoda Duméril, 1805

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/v2x-3p1-tzh
title: †Obolus Eichwald, 1829

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.21949/1530671
title: Air Travel Consumer Report: April 2024 [supporting dataset]

description: These data tables have been extracted from the original 2024 report using ABBYY FineReader PDF Software. This data was exported and cleaned by the NTL Data Services Team. The data is complete and accurate to the original 2000 report. For questions, please contact ntldatacurator@dot.gov National Transportation Library (NTL) Curation Note: This dataset has been curated to CoreTrustSeal's curation level "A. Active Preservation" To find out more information on CoreTrustSeal's curation levels, please consult their "Curation & Preservation Levels" CoreTrustSeal Discussion Paper" (https://doi.org/10.5281/zenodo.11476980). NTL staff last accessed this dataset at its repository URL on 2024-08-1. If, in the future, you have trouble accessing this dataset, please email NTLDataCurator@dot.gov describing your problem. NTL staff will do its best to assist you at that time
description: The Air Travel Consumer Report is a monthly product of the Department of Transportation's Office of Aviation Consumer Protection. The report is designed to assist consumers with information on the quality of services provided by the airlines. 



Data Included in this Report:

"Flight Delays: February 2024  

Mishandled Baggage / Wheelchairs and Scooters: February 2024  

Oversales: 4th Quarter 2023  

Consumer Complaints: See page 43 for details   

Customer Service Reports to the Dept. of Homeland Security: February 2024  

Airline Animal Incident Reports: February 2024



The .xlsx and .xls file types are Microsoft Excel files, which can be opened with Excel, and other free available spreadsheet software, such as OpenRefine. The .csv, Comma Separated Value, file is a simple format that is designed for a database table and supported by many applications. The .csv file is often used for moving tabular data between two different computer programs, due to its open format. The most common software used to open .csv files are Microsoft Excel and RecordEditor, (for more information on .csv files and software, please visit https://www.file-extensions.org/csv-file-extension). The file extension .md is among others related to texts and source codes in Markdown markup language. Markdown is a lightweight markup language, to write using an easy-to-read, easy-to-write plain text format, then convert it to structurally valid XHTML (or HTML) (for more information on .md files and software, please visit https://www.file-extensions.org/md-file-extension). File extension .json is associated to JavaScript Object Notation file format, a lightweight, text-based, language-independent data interchange format. JSON defines a small set of formatting rules for the portable representation of structured data. It is used by various applications as alternative option to XML file format. The data in a json file are stored in simple text file format and the content is viewable in any simple text editor (for more information on .json files and software, please visit https://www.file-extensions.org/json-file-extension).
DOI: 10.3535/n5k-fe3-7pt
title: Brachiopoda Duméril, 1805

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/xkx-mx4-ldb
title: Brachiopoda Duméril, 1805

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/836-jtp-krp
title: Brachiopoda Duméril, 1805

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/ax6-hhh-nkp
title: †Obolus Eichwald, 1829

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.21949/1530672
title: Air Travel Consumer Report: May 2024 [supporting dataset]

description: These data tables have been extracted from the original 2024 report using ABBYY FineReader PDF Software. This data was exported and cleaned by the NTL Data Services Team. The data is complete and accurate to the original 2000 report. For questions, please contact ntldatacurator@dot.gov National Transportation Library (NTL) Curation Note: This dataset has been curated to CoreTrustSeal's curation level "A. Active Preservation" To find out more information on CoreTrustSeal's curation levels, please consult their "Curation & Preservation Levels" CoreTrustSeal Discussion Paper" (https://doi.org/10.5281/zenodo.11476980). NTL staff last accessed this dataset at its repository URL on 2024-08-02. If, in the future, you have trouble accessing this dataset, please email NTLDataCurator@dot.gov describing your problem. NTL staff will do its best to assist you at that time
description: The Air Travel Consumer Report is a monthly product of the Department of Transportation's Office of Aviation Consumer Protection. The report is designed to assist consumers with information on the quality of services provided by the airlines. 



Data Included in this Report:

Flight Delays: March 2024 / January- March 2024

Mishandled Baggage / Wheelchairs and Scooters: March 2024 /January - March 2024

Oversales: 1st Quarter 2024  (January- March 2024)

Consumer Complaints:  See Report for Details

Customer Service Reports to the Dept. of Homeland Security: March 2024

Airline Animal Incident Reports: March 2024



The .xlsx and .xls file types are Microsoft Excel files, which can be opened with Excel, and other free available spreadsheet software, such as OpenRefine. The .csv, Comma Separated Value, file is a simple format that is designed for a database table and supported by many applications. The .csv file is often used for moving tabular data between two different computer programs, due to its open format. The most common software used to open .csv files are Microsoft Excel and RecordEditor, (for more information on .csv files and software, please visit https://www.file-extensions.org/csv-file-extension). The file extension .md is among others related to texts and source codes in Markdown markup language. Markdown is a lightweight markup language, to write using an easy-to-read, easy-to-write plain text format, then convert it to structurally valid XHTML (or HTML) (for more information on .md files and software, please visit https://www.file-extensions.org/md-file-extension). File extension .json is associated to JavaScript Object Notation file format, a lightweight, text-based, language-independent data interchange format. JSON defines a small set of formatting rules for the portable representation of structured data. It is used by various applications as alternative option to XML file format. The data in a json file are stored in simple text file format and the content is viewable in any simple text editor (for more information on .json files and software, please visit https://www.file-extensions.org/json-file-extension).
DOI: 10.3535/8se-960-kxm
title: Brachiopoda Duméril, 1805

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/bd8-d2b-aq5
title: Granite

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/3r8-bg7-vkc
title: Kenophyllum sp.

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/vm0-9wp-vlg
title: Kenophyllum sp.

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/avc-k96-64j
title: Schist

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/wqz-vr5-94g
title: Specimen from Tallinn University of Technology

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/9ea-0jx-qq4
title: sedimentary rocks

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/t64-862-223
title: Minerals

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/08c-qhp-10j
title: †Dianulites petropolitanus Dybowski, 1877 ()

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/vz1-6nv-tvd
title: sedimentary rocks

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/ewg-nvt-l6f
title: Galostylis denticulata

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/x5e-ha5-7gf
title: Specimen from Tallinn University of Technology

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/mtm-lve-1tx
title: Rapakivi granite

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/rrv-z4f-fq2
title: †Subulites Emmons, 1842

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.