cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.1568880.v2
title: Light Actuation of Graphene-Oxide Incorporated Liquid Crystalline Elastomer Nanocomposites

description: The authors demonstrate high-performance photo-actuation of nematic liquid crystal elastomer (LCE) nanocomposites incorporating graphene oxide (GO). The nematic LCE serves as the matrix with reversible thermomechanical response. The incorporated GO absorbs photons and converts the photonic energy to heat, thus actuating the LCE nanocomposite. Both infrared and visible lights of wide spectrum (white light) or various wavelength ranges irradiations are able to effectively actuate the LCE nanocomposites, thus proves that they can fully utilize the photo energy of a light source for their mechanical actuation. Attributed to the well dispersity of GO in LCE matrix, sensitive (in seconds) and reversible photo-induced strain of LCE nanocomposites with consistent shape-changing ratio and significantly enhanced mechanical properties are observed. The contraction of the LCE nanocomposite films under light irradiation is about one third of the original length. The effective load-actuation capability is elevated about 50%.
DOI: 10.6084/m9.figshare.1569038
title: A Supramolecular Framework Structure of a Novel Heterometallic Sn–Zn Dinuclear Cluster Constructed by a Sulfur-Contained Complex Unit

description: GRAPHICAL ABSTRACT
DOI: 10.6084/m9.figshare.1569038.v1
title: A Supramolecular Framework Structure of a Novel Heterometallic Sn–Zn Dinuclear Cluster Constructed by a Sulfur-Contained Complex Unit

description: GRAPHICAL ABSTRACT
DOI: 10.6084/m9.figshare.1569120
title: Endophytic fungi promote plant growth and mitigate the adverse effects of stem rot: An example of <i>Penicillium citrinum</i> and <i>Aspergillus terreus</i>

description: Disease resistance is a highly desirable crop trait in the sustainable agricultural industry. Endophytic fungi with gibberellins (GAs)-secreting potential are now widely known for their ability to stimulate plant growth, but their role in promoting disease resistance in plants has rarely been reported. We have studied the role of <i>Penicillium citrinum</i> LWL4 and <i>Aspergillus terreus</i> LWL5 in time dependent manner on sunflower (<i>Helianthus annuus</i> L.) growth, disease resistance and their capacity for the regulation of hormone signaling networks involved in plant defense against the stem rot caused by <i>Sclerotium rolfsii</i> for 3, 6 and 12 days after treatment (DAT). Our results show that plant growth characteristics, (i.e., shoot length, shoot diameter, shoot fresh/dry weight, transpiration, stomatal conductance, photosynthesis, and chlorophyll content) were promoted in fungi-treated plants with or without the disease caused by <i>Sclerotium rolfsii</i> as compared to their respective controls in 3, 6 and 12DAT. The negative impacts of stem rot in endophyte treated diseased plants were greatly reduced in comparison to control diseased plants shown by low disease severity in 3, 6 and 12 DAT. Similarly, fungal endophytes in diseased plants relieved the biotic stress in time dependent manner (3, 6 and 12DAT) as shown by low level of endogenous SA and JA contents and were significantly higher in control diseased plants. Furthermore, we observed that the <i>Penicillium citrinum</i> LWL4 association had a greater positive effect on sunflower plants than <i>Aspergillus terreus</i> LWL5. It was concluded that inoculation with fungal endophytes reprogrammed plant growth during disease incidence by regulating responses associated with host plant defense. Management strategies involving endophytic symbiosis can help achieve sustainability in agriculture in an eco-friendly manner by reducing excessive fungicide use.Supplement_Data.zip
DOI: 10.6084/m9.figshare.1569120.v1
title: Endophytic fungi promote plant growth and mitigate the adverse effects of stem rot: an example of <i>Penicillium citrinum</i> and <i>Aspergillus terreus</i>

description: Disease resistance is a highly desirable crop trait in the sustainable agricultural industry. Endophytic fungi with gibberellins-secreting potential are now widely known for their ability to stimulate plant growth, but their role in promoting disease resistance in plants has rarely been reported. We have studied the role of <i>Penicillium citrinum</i> LWL4 and <i>Aspergillus terreus</i> LWL5 in time-dependent manner on sunflower (<i>Helianthus annuus</i> L.) growth, disease resistance and their capacity for the regulation of hormone signaling networks involved in plant defense against the stem rot caused by <i>Sclerotium rolfsii</i> for 3, 6 and 12 days after treatment (DAT). Our results show that plant growth characteristics (i.e. shoot length, shoot diameter, shoot fresh/dry weight, transpiration, stomatal conductance, photosynthesis and chlorophyll content) were promoted in fungi-treated plants with or without the disease caused by <i>Sclerotium rolfsii</i> as compared to their respective controls in 3, 6 and 12 DAT. The negative impacts of stem rot in endophyte-treated diseased plants were greatly reduced in comparison to control diseased plants shown by low disease severity in 3, 6 and 12 DAT. Similarly, fungal endophytes in diseased plants relieved the biotic stress in time-dependent manner (3, 6 and 12 DAT) as shown by low level of endogenous salicylic acid and jasmonic acid contents and were significantly higher in control diseased plants. Furthermore, we observed that the <i>Penicillium citrinum</i> LWL4 association had a greater positive effect on sunflower plants than <i>Aspergillus terreus</i> LWL5. It was concluded that inoculation with fungal endophytes reprogramed plant growth during disease incidence by regulating responses associated with host plant defense. Management strategies involving endophytic symbiosis can help achieve sustainability in agriculture in an eco-friendly manner by reducing excessive fungicide use.
DOI: 10.6084/m9.figshare.1569120.v2
title: Endophytic fungi promote plant growth and mitigate the adverse effects of stem rot: An example of <i>Penicillium citrinum</i> and <i>Aspergillus terreus</i>

description: Disease resistance is a highly desirable crop trait in the sustainable agricultural industry. Endophytic fungi with gibberellins (GAs)-secreting potential are now widely known for their ability to stimulate plant growth, but their role in promoting disease resistance in plants has rarely been reported. We have studied the role of <i>Penicillium citrinum</i> LWL4 and <i>Aspergillus terreus</i> LWL5 in time dependent manner on sunflower (<i>Helianthus annuus</i> L.) growth, disease resistance and their capacity for the regulation of hormone signaling networks involved in plant defense against the stem rot caused by <i>Sclerotium rolfsii</i> for 3, 6 and 12 days after treatment (DAT). Our results show that plant growth characteristics, (i.e., shoot length, shoot diameter, shoot fresh/dry weight, transpiration, stomatal conductance, photosynthesis, and chlorophyll content) were promoted in fungi-treated plants with or without the disease caused by <i>Sclerotium rolfsii</i> as compared to their respective controls in 3, 6 and 12DAT. The negative impacts of stem rot in endophyte treated diseased plants were greatly reduced in comparison to control diseased plants shown by low disease severity in 3, 6 and 12 DAT. Similarly, fungal endophytes in diseased plants relieved the biotic stress in time dependent manner (3, 6 and 12DAT) as shown by low level of endogenous SA and JA contents and were significantly higher in control diseased plants. Furthermore, we observed that the <i>Penicillium citrinum</i> LWL4 association had a greater positive effect on sunflower plants than <i>Aspergillus terreus</i> LWL5. It was concluded that inoculation with fungal endophytes reprogrammed plant growth during disease incidence by regulating responses associated with host plant defense. Management strategies involving endophytic symbiosis can help achieve sustainability in agriculture in an eco-friendly manner by reducing excessive fungicide use.Supplement_Data.zip
DOI: 10.6084/m9.figshare.1569286
title: Nightshift work and genome-wide DNA methylation

description: The negative health effects of shift work, including carcinogenesis, may be mediated by changes in DNA methylation, particularly in the circadian genes. Using the Infinium HumanMethylation450 Bead Array (Illumina, San Diego, CA), we compared genome-wide methylation between 65 actively working dayshift workers and 59 actively working nightshift workers in the healthcare industry. A total of 473 800 loci, including 391 loci across the 12 core circadian genes, were analyzed to identify methylation markers associated with shift work status using linear regression models adjusted for gender, age, body mass index, race, smoking status and leukocyte cell profile as measured by flow cytometry. Analyses at the level of gene, CpG island and gene region were also conducted. To account for multiple comparisons, we controlled the false discovery rate (FDR ≤0.05). Significant differences between nightshift and dayshift workers were found at 16 135 of 473 800 loci, across 3769 of 20 164 genes, across 7173 of 22 721 CpG islands and across 5508 of 51 843 gene regions. For each significant loci, gene, CpG island or gene region, average methylation was consistently found to be decreased among nightshift workers compared to dayshift workers. Twenty-one loci located in the circadian genes were also found to be significantly hypomethylated among nightshift workers. The largest differences were observed for three loci located in the gene body of <i>PER3</i>. A total of nine significant loci were found in the <i>CSNK1E</i> gene, most of which were located in a CpG island and near the transcription start site of the gene. Methylation changes in these circadian genes may lead to altered expression of these genes which has been associated with cancer in previous studies. Gene ontology enrichment analysis revealed that among the significantly hypomethylated genes, processes related to host defense and immunity were represented. Our results indicate that the health effects of shift work may be mediated by hypomethylation of a wide variety of genes, including those related to circadian rhythms. While these findings need to be followed-up among a considerably expanded group of shift workers, the data generated by this study supports the need for future targeted research into the potential impacts of shift work on specific carcinogenic mechanisms.
DOI: 10.6084/m9.figshare.1569286.v1
title: Nightshift work and genome-wide DNA methylation

description: The negative health effects of shift work, including carcinogenesis, may be mediated by changes in DNA methylation, particularly in the circadian genes. Using the Infinium HumanMethylation450 Bead Array (Illumina, San Diego, CA), we compared genome-wide methylation between 65 actively working dayshift workers and 59 actively working nightshift workers in the healthcare industry. A total of 473 800 loci, including 391 loci across the 12 core circadian genes, were analyzed to identify methylation markers associated with shift work status using linear regression models adjusted for gender, age, body mass index, race, smoking status and leukocyte cell profile as measured by flow cytometry. Analyses at the level of gene, CpG island and gene region were also conducted. To account for multiple comparisons, we controlled the false discovery rate (FDR ≤0.05). Significant differences between nightshift and dayshift workers were found at 16 135 of 473 800 loci, across 3769 of 20 164 genes, across 7173 of 22 721 CpG islands and across 5508 of 51 843 gene regions. For each significant loci, gene, CpG island or gene region, average methylation was consistently found to be decreased among nightshift workers compared to dayshift workers. Twenty-one loci located in the circadian genes were also found to be significantly hypomethylated among nightshift workers. The largest differences were observed for three loci located in the gene body of <i>PER3</i>. A total of nine significant loci were found in the <i>CSNK1E</i> gene, most of which were located in a CpG island and near the transcription start site of the gene. Methylation changes in these circadian genes may lead to altered expression of these genes which has been associated with cancer in previous studies. Gene ontology enrichment analysis revealed that among the significantly hypomethylated genes, processes related to host defense and immunity were represented. Our results indicate that the health effects of shift work may be mediated by hypomethylation of a wide variety of genes, including those related to circadian rhythms. While these findings need to be followed-up among a considerably expanded group of shift workers, the data generated by this study supports the need for future targeted research into the potential impacts of shift work on specific carcinogenic mechanisms.
DOI: 10.6084/m9.figshare.1569326
title: Fusion with pep-1, a cell-penetrating peptide, enhances the transmembrane ability of human epidermal growth factor

description: Administration of macromolecule compositions in medicine and cosmetics always exhibited low bioavailability due to the limitation of transmembrane transport. Here, human epidermal growth factor (hEGF) was fused with glutathione S-transferase (GST) and Pep-1, the first commercial cell-penetrating peptide, in <i>Escherichia coli</i>. The fusion protein was firstly purified with the affinity chromatography, and then the GST tag was released by TEV protease. Final purification was achieved by the ion exchange chromatography. The biological activities and the transmembrane ability of the obtained products were determined using scratch wound-healing assay, MTT analysis, and immunofluorescence assay. The results showed that both rhEGF and Pep-1-fused hEGF were soluble expressed in <i>E. coli</i>. The fusion of Pep-1 could markedly increase the transmembrane ability of EGF, whereas it did not interfere with the growth-stimulating and migration-promoting functions of hEGF on fibroblasts. This research provided a novel strategy for the transmembrane transport of protein-derived cosmetics or drugs.
DOI: 10.6084/m9.figshare.1569326.v1
title: Fusion with pep-1, a cell-penetrating peptide, enhances the transmembrane ability of human epidermal growth factor

description: Administration of macromolecule compositions in medicine and cosmetics always exhibited low bioavailability due to the limitation of transmembrane transport. Here, human epidermal growth factor (hEGF) was fused with glutathione S-transferase (GST) and Pep-1, the first commercial cell-penetrating peptide, in <i>Escherichia coli</i>. The fusion protein was firstly purified with the affinity chromatography, and then the GST tag was released by TEV protease. Final purification was achieved by the ion exchange chromatography. The biological activities and the transmembrane ability of the obtained products were determined using scratch wound-healing assay, MTT analysis, and immunofluorescence assay. The results showed that both rhEGF and Pep-1-fused hEGF were soluble expressed in <i>E. coli</i>. The fusion of Pep-1 could markedly increase the transmembrane ability of EGF, whereas it did not interfere with the growth-stimulating and migration-promoting functions of hEGF on fibroblasts. This research provided a novel strategy for the transmembrane transport of protein-derived cosmetics or drugs.
DOI: 10.6084/m9.figshare.1569349
title: Mechano growth factor E peptide promotes rat bone marrow-derived mesenchymal stem cell migration through CXCR4-ERK1/2

description: Mechano growth factor (MGF) is a splicing variant of insulin-like growth factor 1 (IGF-1). The unique C-terminal E domain of MGF (MGF-E) makes it distinct from the other variants of IGF-1. Our previous work demonstrated that MGF-25E induces the migration of rat bone marrow-derived mesenchymal stem cells (rMSCs) by altering their mechanical properties, which is accompanied by the activation of the extracellular signal-regulated kinase 1/2 (ERK1/2) pathway. However, the relationship between ERK1/2 activation and the change in mechanical properties has not been illustrated. In the present study, we determined that MGF-25E induced the migration of rMSCs by modulating CXCR4 to activate the ERK1/2 pathway. The analysis of the Young’s modulus and F-actin remodeling indicated that MGF-25E increased the stiffness and the F-actin polymerization of rMSCs through the activation of the CXCR4-ERK1/2 pathway. For the first time, this study clarified the signaling pathway that regulates the mechanical properties of rMSCs and is responsible for MGF-25E-promoted migration.
DOI: 10.6084/m9.figshare.1569349.v1
title: Mechano growth factor E peptide promotes rat bone marrow-derived mesenchymal stem cell migration through CXCR4-ERK1/2

description: Mechano growth factor (MGF) is a splicing variant of insulin-like growth factor 1 (IGF-1). The unique C-terminal E domain of MGF (MGF-E) makes it distinct from the other variants of IGF-1. Our previous work demonstrated that MGF-25E induces the migration of rat bone marrow-derived mesenchymal stem cells (rMSCs) by altering their mechanical properties, which is accompanied by the activation of the extracellular signal-regulated kinase 1/2 (ERK1/2) pathway. However, the relationship between ERK1/2 activation and the change in mechanical properties has not been illustrated. In the present study, we determined that MGF-25E induced the migration of rMSCs by modulating CXCR4 to activate the ERK1/2 pathway. The analysis of the Young’s modulus and F-actin remodeling indicated that MGF-25E increased the stiffness and the F-actin polymerization of rMSCs through the activation of the CXCR4-ERK1/2 pathway. For the first time, this study clarified the signaling pathway that regulates the mechanical properties of rMSCs and is responsible for MGF-25E-promoted migration.
DOI: 10.6084/m9.figshare.1569356
title: Fused Adaptive Lasso for Spatial and Temporal Quantile Function Estimation

description: Quantile functions are important in characterizing the entire probability distribution of a random variable, especially when the tail of a skewed distribution is of interest. This article introduces new quantile function estimators for spatial and temporal data with a fused adaptive Lasso penalty to accommodate the dependence in space and time. This method penalizes the difference among neighboring quantiles, hence it is desirable for applications with features ordered in time or space without replicated observations. The theoretical properties are investigated and the performance of the proposed methods are evaluated by simulations. The proposed method is applied to particulate matter (PM) data from the Community Multiscale Air Quality (CMAQ) model to characterize the upper quantiles, which are crucial for studying spatial association between PM concentrations and adverse human health effects.
DOI: 10.6084/m9.figshare.1569356.v2
title: Fused Adaptive Lasso for Spatial and Temporal Quantile Function Estimation

description: Quantile functions are important in characterizing the entire probability distribution of a random variable, especially when the tail of a skewed distribution is of interest. This article introduces new quantile function estimators for spatial and temporal data with a fused adaptive Lasso penalty to accommodate the dependence in space and time. This method penalizes the difference among neighboring quantiles, hence it is desirable for applications with features ordered in time or space without replicated observations. The theoretical properties are investigated and the performance of the proposed methods are evaluated by simulations. The proposed method is applied to particulate matter (PM) data from the Community Multiscale Air Quality (CMAQ) model to characterize the upper quantiles, which are crucial for studying spatial association between PM concentrations and adverse human health effects.
DOI: 10.6084/m9.figshare.1569356.v1
title: Fused Adaptive Lasso for Spatial and Temporal Quantile Function Estimation

description: Quantile functions are important in characterizing the entire probability distribution of a random variable, especially when the tail of a skewed distribution is of interest. This article introduces new quantile function estimators for spatial and temporal data with a fused adaptive Lasso penalty to accommodate the dependence in space and time. This method penalizes the difference among neighboring quantiles, hence it is desirable for applications with features ordered in time or space without replicated observations. The theoretical properties are investigated and the performance of the proposed methods are evaluated by simulations. The proposed method is applied to particulate matter (PM) data from the Community Multiscale Air Quality (CMAQ) model to characterize the upper quantiles, which are crucial for studying spatial association between PM concentrations and adverse human health effects.
DOI: 10.34740/kaggle/dsv/7929627
title: 2021 World Population (updated daily)
DOI: 10.6084/m9.figshare.1569845
title: Syntheses, Crystal Structure, Characterization, and Properties of Two Novel Superamolecular Phosphotungstate-Pyridine Complexes

description: Two new inorganic-organic compounds constructed from phosphotungstate and pyridines have been synthesized under hydrothermal conditions. The formulas of the two compounds are (C<sub>5</sub>H<sub>7</sub>N<sub>2</sub>)<sub>3</sub>(C<sub>5</sub>H<sub>6</sub>N<sub>2</sub>)<sub>3</sub>(PW<sub>12</sub>O<sub>40</sub>)·2H<sub>2</sub>O (<b>1</b>) and (C<sub>6</sub>H<sub>8</sub>N)<sub>3</sub>(C<sub>6</sub>H<sub>7</sub>N)(PW<sub>12</sub>O<sub>40</sub>)·9H<sub>2</sub>O (<b>2</b>). They have been characterized by IR, UV-vis, TG-DTA, FL, CV, and single-crystal X-ray diffraction. The two compounds both show three-dimensional networks. These compounds exhibit good catalytic activity for catalytic oxidation of methanol over a continuous-flow fixed-bed microreactor, when the initial concentration of methanol is 5.37 g⋅m<sup>−3</sup>, and flow rate is 4.51 mL⋅min<sup>−1</sup>. 0.2 g compound <b>1</b> (or compound <b>2)</b> as the catalyst can eliminate methanol completely at 150°C (175°C for compound <b>2</b>).
DOI: 10.6084/m9.figshare.1569845.v1
title: Syntheses, Crystal Structure, Characterization and Properties of Two Novel Superamolecular Phosphotungstate-Pyriding Complexes

description: Two new inorganic-organic compounds constructed from phosphotungstate and pyridines have been synthesized under hydrothermal conditions. The formula of two compounds are (C<sub>5</sub>H<sub>7</sub>N<sub>2</sub>)<sub>3</sub>(C<sub>5</sub>H<sub>6</sub>N<sub>2</sub>)<sub>3</sub>(PW<sub>12</sub>O<sub>40</sub>)·2H<sub>2</sub>O (<b>1</b>), (C<sub>6</sub>H<sub>8</sub>N)<sub>3</sub>(C<sub>6</sub>H<sub>7</sub>N)(PW<sub>12</sub>O<sub>40</sub>)·9H<sub>2</sub>O (<b>2</b>). They have been characterized by IR, UV-vis, TG-DTA, FL, CV and single-crystal X-ray diffraction. The two compounds are both show three-dimensional network. These compounds exhibit good catalytic activity for catalytic oxidation of methanol over a continuous-flow fixed-bed micro-reactor, when the initial concentration of methanol is 5.37 g×m<sup>−3</sup>, and flow rate is 4.51 mL×min<sup>−1</sup>. 0.2 g compound <b>1 (or</b> compound <b>2)</b> as the catalyst can eliminates methanol completely at 150 °C (175 °C for compound <b>2</b>).