cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.1031660.v4
title: Public health and components of particulate matter: The changing assessment of black carbon

description: In 2012, the WHO classified diesel emissions as carcinogenic, and its European branch suggested creating a public health standard for airborne black carbon (BC). In 2011, EU researchers found that life expectancy could be extended four to nine times by reducing a unit of BC, vs reducing a unit of PM<sub>2.5.</sub> Only recently could such determinations be made. Steady improvements in research methodologies now enable such judgments.In this Critical Review, we survey epidemiological and toxicological literature regarding carbonaceous combustion emissions, as research methodologies improved over time. Initially, we focus on studies of BC, diesel, and traffic emissions in the Western countries (where daily urban BC emissions are mainly from diesels). We examine effects of other carbonaceous emissions, e.g., residential burning of biomass and coal without controls, mainly in developing countries.Throughout the 1990s, air pollution epidemiology studies rarely included species not routinely monitored. As additional PM<sub>2.5.</sub> chemical species, including carbonaceous species, became more widely available after 1999, they were gradually included in epidemiological studies. Pollutant species concentrations which more accurately reflected subject exposure also improved models.Natural “interventions” - reductions in emissions concurrent with fuel changes or increased combustion efficiency; introduction of ventilation in highway tunnels; implementation of electronic toll payment systems – demonstrated health benefits of reducing specific carbon emissions. Toxicology studies provided plausible biological mechanisms by which different PM species, e.g., carbonaceous species, may cause harm, aiding interpretation of epidemiological studies.Our review finds that BC from various sources appears to be causally involved in all-cause, lung cancer, and cardiovascular mortality, morbidity, and perhaps adverse birth and nervous system effects. We recommend that the U.S. EPA rubric for judging possible causality of PM<sub>2.5.</sub> mass concentrations, be used to assess which PM<sub>2.5.</sub> species are most harmful to public health.Implications: <i>Black carbon (BC) and correlated co-emissions appear causally related with all-cause, cardiovascular, and lung cancer mortality, and perhaps with adverse birth outcomes and central nervous system effects. Such findings are recent, since widespread monitoring for BC is also recent. Helpful epidemiological advances (using many health relevant PM<sub>2.5</sub> species in models; using better measurements of subject exposure) have also occurred. “Natural intervention” studies also demonstrate harm from partly combusted carbonaceous emissions. Toxicology studies consistently find biological mechanisms explaining how such emissions can cause these adverse outcomes. A consistent mechanism for judging causality for different PM<sub>2.5</sub> species is suggested.</i><i>A list of acronyms will be found at the end of the article.</i>
DOI: 10.6084/m9.figshare.1031662.v3
title: IL-4 in Autoimmune Flaky Skin Mice

description: Flaky skin mutant (Ttc7fsn) mice display systemic immune dysfunction including splenomegaly, glomerulonephritis, elevated levels of serum IgE, a substantial increase in the number of splenic B cells and a dramatic increase in IL-4 production. Previous work indicated constitutively activated Stat6 in splenic B cells; herein we have demonstrated this to be the result of continuous IL-4 signaling as nuclear localization studies suggested B cells have the ability to turn over activated Stat6 ex vivo when the IL-4 signal is removed. In addition, actinomycin D studies provide evidence for an increase in IL-4 mRNA stability which leads to dramatically increased IL-4 protein production resulting in a driving force toward systemic autoimmunity. Although the function of the Ttc7fsn gene is as yet unknown, we suggest that it may lead to a greater understanding of the mechanisms involved in IL-4 regulation.
DOI: 10.6084/m9.figshare.1031660.v3
title: Public health and components of particulate matter: The changing assessment of black carbon

description: In 2012, the WHO classified diesel emissions as carcinogenic, and its European branch suggested creating a public health standard for airborne black carbon (BC). In 2011, EU researchers found that life expectancy could be extended four to nine times by reducing a unit of BC, vs reducing a unit of PM<sub>2.5.</sub> Only recently could such determinations be made. Steady improvements in research methodologies now enable such judgments.In this Critical Review, we survey epidemiological and toxicological literature regarding carbonaceous combustion emissions, as research methodologies improved over time. Initially, we focus on studies of BC, diesel, and traffic emissions in the Western countries (where daily urban BC emissions are mainly from diesels). We examine effects of other carbonaceous emissions, e.g., residential burning of biomass and coal without controls, mainly in developing countries.Throughout the 1990s, air pollution epidemiology studies rarely included species not routinely monitored. As additional PM<sub>2.5.</sub> chemical species, including carbonaceous species, became more widely available after 1999, they were gradually included in epidemiological studies. Pollutant species concentrations which more accurately reflected subject exposure also improved models.Natural “interventions” - reductions in emissions concurrent with fuel changes or increased combustion efficiency; introduction of ventilation in highway tunnels; implementation of electronic toll payment systems – demonstrated health benefits of reducing specific carbon emissions. Toxicology studies provided plausible biological mechanisms by which different PM species, e.g., carbonaceous species, may cause harm, aiding interpretation of epidemiological studies.Our review finds that BC from various sources appears to be causally involved in all-cause, lung cancer, and cardiovascular mortality, morbidity, and perhaps adverse birth and nervous system effects. We recommend that the U.S. EPA rubric for judging possible causality of PM<sub>2.5.</sub> mass concentrations, be used to assess which PM<sub>2.5.</sub> species are most harmful to public health.Implications: <i>Black carbon (BC) and correlated co-emissions appear causally related with all-cause, cardiovascular, and lung cancer mortality, and perhaps with adverse birth outcomes and central nervous system effects. Such findings are recent, since widespread monitoring for BC is also recent. Helpful epidemiological advances (using many health relevant PM<sub>2.5</sub> species in models; using better measurements of subject exposure) have also occurred. “Natural intervention” studies also demonstrate harm from partly combusted carbonaceous emissions. Toxicology studies consistently find biological mechanisms explaining how such emissions can cause these adverse outcomes. A consistent mechanism for judging causality for different PM<sub>2.5</sub> species is suggested.</i><i>A list of acronyms will be found at the end of the article.</i>
DOI: 10.6084/m9.figshare.1031637
title: Jean-Claude Bradley Open Melting Point Dataset

description: Jean-Claude Bradley's Legacy Dataset of Open Melting Points. 28,645 measurements including those found to be incorrect (marked as 'do not use'). csid corresponds to Chemspider ID.
DOI: 10.6084/m9.figshare.1031657.v2
title: KLOTHO protein sequences (sixteen species) FULL DATASET

description: Genomic data & Amino Acid composition Including: Heterocephalus glaber, Chinchilla lanigera, Ochotona princeps, Mus musculus, Rattus norvegicus, Mesocricetus auratus, Peromyscus maniculatus bairdii, Microtus ochrogaster, Chrysochloris asiatica, Cricetulus griseus, Elephantulus edwardii, Ictidomys tridecemlineatus, Erinaceus europaeus, Condylura cristata, Octodon degus, Jaculus jaculus
DOI: 10.6084/m9.figshare.1031636
title: Carbon stocks in human-modified tropical forests

description: Data used in the paper <em>A large-scale field assessment of carbon stocks in human-modified tropical forests</em> by Berenguer et al. 2014 published in Global Change Biology, DOI: 10.1111/gcb.12627. http://onlinelibrary.wiley.com/doi/10.1111/gcb.12627/full
DOI: 10.6084/m9.figshare.1031657.v1
title: KLOTHO phylogeny reconstruction (sixteen sequences) FULL DATASET

description: Genomic data & Amino Acid composition Including: Heterocephalus glaber, Chinchilla lanigera, Ochotona princeps, Mus musculus, Rattus norvegicus, Mesocricetus auratus, Peromyscus maniculatus bairdii, Microtus ochrogaster, Chrysochloris asiatica, Cricetulus griseus, Elephantulus edwardii, Ictidomys tridecemlineatus, Erinaceus europaeus, Condylura cristata, Octodon degus, Jaculus jaculus
DOI: 10.6084/m9.figshare.1031627
title: Cell Patterning with a heptagon acoustic tweezer: applications in neurite guidance

description: PPTshow in support of the following paper: Cell patterning with a heptagon acoustic tweezer – application in neurite guidance F. Gesellchen, A. L. Bernassau, T. Déjardin, D. R. S. Cumming and M. O. Riehle Lab Chip, 2014 DOI: 10.1039/C4LC00436A<br>Received 10 Apr 2014, Accepted 28 Apr 2014<br>First published online 28 Apr 2014
DOI: 10.6084/m9.figshare.1031616
title: de novo assembly of transcriptome of Pekin Duck Anas platyrhynchos domestica.

description: Fasta file of de novo assembly of transcriptome of Pekin Duck <em>Anas platyrhynchos domestica. </em> <em>See Moreton et al. Submitted Frontiers in Bioinformatics and Computational Biology 2014<br></em>
DOI: 10.6084/m9.figshare.1031616.v1
title: de novo assembly of transcriptome of Pekin Duck Anas platyrhynchos domestica.

description: Fasta file of de novo assembly of transcriptome of Pekin Duck <em>Anas platyrhynchos domestica. </em> <em>See Moreton et al. Submitted Frontiers in Bioinformatics and Computational Biology 2014<br></em>
DOI: 10.6084/m9.figshare.1031581
title: Deacetylase activities of rHos2 and dose response curves of rHos2 inhibition by standard HDAC inhibitors: UPDATE 1

description: Dose response curve of rHos2 enzyme inhibition by MS275: Fluorimetric deacetylase assay with rHos2 protein using Boc-Lys(ac)-AMC substrate in presence of different concentrations of MS-275. Dose response curve of rHos2 enzyme inhibition by SAHA: Fluorimetric deacetylase assay with rHos2 protein using Boc-Lys(ac)-AMC substrate in presence of different concentrations of suberoylanilide hydroxamic acid (SAHA). Dose response curve of rHos2 enzyme inhibition by TSA: Fluorimetric deacetylase assay with rHos2 protein using Boc-Lys(ac)-AMC substrate in presence of different concentrations of trichostatin. rHos2 conc_Enzyme activity: Fluorimetric deacetylase assay with rHos2 protein using Boc-Lys(ac)-AMC substrate. Updated from: http://dx.doi.org/10.6084/m9.figshare.841655
DOI: 10.6084/m9.figshare.1031579
title: Sirtuin assay of purified Hos2 preparations using resveratrol: UPDATE 1

description: Fluorimetric Sirtuin1 like deacetylase assay with rHos2 protein using Fluor de Lys®−Sirt1 substrate in presence of Sirtuin1 activator Reserveratrol. This experiment is carried out in presence of HDAC inhibitor Trichostatin to inhibit any residual Histone deacetylase activity. Updated from: http://dx.doi.org/10.6084/m9.figshare.841658.
DOI: 10.6084/m9.figshare.1031581.v1
title: Deacetylase activities of rHos2 and dose response curves of rHos2 inhibition by standard HDAC inhibitors: UPDATE 1

description: Dose response curve of rHos2 enzyme inhibition by MS275: Fluorimetric deacetylase assay with rHos2 protein using Boc-Lys(ac)-AMC substrate in presence of different concentrations of MS-275. Dose response curve of rHos2 enzyme inhibition by SAHA: Fluorimetric deacetylase assay with rHos2 protein using Boc-Lys(ac)-AMC substrate in presence of different concentrations of suberoylanilide hydroxamic acid (SAHA). Dose response curve of rHos2 enzyme inhibition by TSA: Fluorimetric deacetylase assay with rHos2 protein using Boc-Lys(ac)-AMC substrate in presence of different concentrations of trichostatin. rHos2 conc_Enzyme activity: Fluorimetric deacetylase assay with rHos2 protein using Boc-Lys(ac)-AMC substrate. Updated from: http://dx.doi.org/10.6084/m9.figshare.841655
DOI: 10.6084/m9.figshare.1031575
title: Aluminium-1field/GCR-RelativeResidual

description: Relative residual of the aluminium-air for the vibro-acoustic test. The settings and input files are in the files .feb.
DOI: 10.6084/m9.figshare.1031579.v1
title: Sirtuin assay of purified Hos2 preparations using resveratrol: UPDATE 1

description: Fluorimetric Sirtuin1 like deacetylase assay with rHos2 protein using Fluor de Lys®−Sirt1 substrate in presence of Sirtuin1 activator Reserveratrol. This experiment is carried out in presence of HDAC inhibitor Trichostatin to inhibit any residual Histone deacetylase activity. Updated from: http://dx.doi.org/10.6084/m9.figshare.841658.
DOI: 10.6084/m9.figshare.1031569
title: Populations of Human Atrial Cell Models

description: AP traces within the populations of models with the Maleckar, the Courtemanche and the Grandi models before calibration and for SR and cAF conditions. Variations of the ionic conductances are also included for each AP trace.
DOI: 10.6084/m9.figshare.1031558
title: Gaussian Job Archive for C33H27CuI2N3P

description: Archive of work produced using the resources of the Imperial College High Performance Computing Service.
DOI: 10.6084/m9.figshare.1031567
title: Calibrated Population Grandi SR

description: AP traces following 90 periodic stimuli (at 1 Hz, 2.5 Hz and 3 Hz) within the population of models with the Grandi model for SR conditions. Variations of the ionic conductances within ±30% range with respect to the median values are also included for each AP trace.
DOI: 10.6084/m9.figshare.1031575.v1
title: Aluminium-1field/GCR-RelativeResidual

description: Relative residual of the aluminium-air for the vibro-acoustic test. The settings and input files are in the files .feb.
DOI: 10.6084/m9.figshare.1031558.v1
title: Gaussian Job Archive for C33H27CuI2N3P

description: Archive of work produced using the resources of the Imperial College High Performance Computing Service.
DOI: 10.6084/m9.figshare.1031567.v1
title: Calibrated Population Grandi SR

description: AP traces following 90 periodic stimuli (at 1 Hz, 2.5 Hz and 3 Hz) within the population of models with the Grandi model for SR conditions. Variations of the ionic conductances within ±30% range with respect to the median values are also included for each AP trace.
DOI: 10.6084/m9.figshare.1031552
title: The inner ear morphology of the ‘condylarthran’ <i>Hyopsodus lepidus</i>

description: We describe the bony labyrinth morphology of the Eocene ‘archaic ungulate’ <i>Hyopsodus</i><i>lepidus</i> (Bridgerian, North America) reconstructed from micro computed tomography scan data. Comparisons with the inner ear of the Eocene early diverging artiodactyl <i>Diacodexis</i> and perissodactyl <i>Xenicohippus</i> allow refining the picture of the ancestral inner ear morphology of Euungulates. These taxa are very close morphologically and mostly differ by slight differences in their semicircular canal angulations and profile. They all present a secondary crus and a low position of the plane of the lateral semicircular canal relative to the posterior semicircular canal. These two characters, considered as ancestral features for Theria, might be symplesiomorphies of Euungulata as well. <i>Hyopsodus</i> and <i>Xenicohippus</i> share characters also observed in other basal Equoidea, which would support the close relationship between these two taxa previously proposed in the literature. A functional study of the cochlea of <i>Hyopsodus lepidus</i> is also realised to discuss its putative ability of using terrestrial echolocation previously proposed in the literature. The morphology of the cochlea of <i>Hyopsodus lepidus</i> does not indicate a specialisation to sophisticated echolocation such as observed today in microchiropteran bats. However, its estimated audible range of frequencies (208 Hz to 76.8 KHz) would be compatible with terrestrial echolocation.
DOI: 10.6084/m9.figshare.1031569.v2
title: Populations of Human Atrial Cell Models

description: AP traces within the populations of models with the Maleckar, the Courtemanche and the Grandi models before calibration and for SR and cAF conditions. Variations of the ionic conductances are also included for each AP trace.
DOI: 10.6084/m9.figshare.1031569.v1
title: Populations of Human Atrial Cell Models

description: AP traces within the populations of models with the Maleckar, the Courtemanche and the Grandi models before calibration and for SR and cAF conditions. Variations of the ionic conductances are also included for each AP trace.
DOI: 10.6084/m9.figshare.1031544
title: Fish activity data: Update 1

description: Prestimulus activities, activity changes and body measurements of Pelvicachromis taeniatus in the three experimental treatments (kin-cues, non-kin-cues and control-cues). Fish standard length (cm), weight (g) and pre-stimulus activities (m) have been added to original data set (http://dx.doi.org/10.6084/m9.figshare.96320).
DOI: 10.6084/m9.figshare.1031504
title: Gaussian Job Archive for C10H24Cu2I3N3P2

description: Archive of work produced using the resources of the Imperial College High Performance Computing Service.
DOI: 10.6084/m9.figshare.1031544.v1
title: Fish activity data: Update 1

description: Prestimulus activities, activity changes and body measurements of Pelvicachromis taeniatus in the three experimental treatments (kin-cues, non-kin-cues and control-cues). Fish standard length (cm), weight (g) and pre-stimulus activities (m) have been added to original data set (http://dx.doi.org/10.6084/m9.figshare.96320).
DOI: 10.6084/m9.figshare.1031504.v1
title: Gaussian Job Archive for C10H24Cu2I3N3P2

description: Archive of work produced using the resources of the Imperial College High Performance Computing Service.
DOI: 10.6084/m9.figshare.1031552.v1
title: The inner ear morphology of the ‘condylarthran’ <i>Hyopsodus lepidus</i>

description: We describe the bony labyrinth morphology of the Eocene ‘archaic ungulate’ <i>Hyopsodus</i><i>lepidus</i> (Bridgerian, North America) reconstructed from micro computed tomography scan data. Comparisons with the inner ear of the Eocene early diverging artiodactyl <i>Diacodexis</i> and perissodactyl <i>Xenicohippus</i> allow refining the picture of the ancestral inner ear morphology of Euungulates. These taxa are very close morphologically and mostly differ by slight differences in their semicircular canal angulations and profile. They all present a secondary crus and a low position of the plane of the lateral semicircular canal relative to the posterior semicircular canal. These two characters, considered as ancestral features for Theria, might be symplesiomorphies of Euungulata as well. <i>Hyopsodus</i> and <i>Xenicohippus</i> share characters also observed in other basal Equoidea, which would support the close relationship between these two taxa previously proposed in the literature. A functional study of the cochlea of <i>Hyopsodus lepidus</i> is also realised to discuss its putative ability of using terrestrial echolocation previously proposed in the literature. The morphology of the cochlea of <i>Hyopsodus lepidus</i> does not indicate a specialisation to sophisticated echolocation such as observed today in microchiropteran bats. However, its estimated audible range of frequencies (208 Hz to 76.8 KHz) would be compatible with terrestrial echolocation.
DOI: 10.6084/m9.figshare.1030651
title: Gaussian Job Archive for C20H20ClCuIN5

description: Archive of work produced using the resources of the Imperial College High Performance Computing Service.
DOI: 10.6084/m9.figshare.1031552.v3
title: The inner ear morphology of the ‘condylarthran’ <i>Hyopsodus lepidus</i>

description: We describe the bony labyrinth morphology of the Eocene ‘archaic ungulate’ <i>Hyopsodus</i><i>lepidus</i> (Bridgerian, North America) reconstructed from micro computed tomography scan data. Comparisons with the inner ear of the Eocene early diverging artiodactyl <i>Diacodexis</i> and perissodactyl <i>Xenicohippus</i> allow refining the picture of the ancestral inner ear morphology of Euungulates. These taxa are very close morphologically and mostly differ by slight differences in their semicircular canal angulations and profile. They all present a secondary crus and a low position of the plane of the lateral semicircular canal relative to the posterior semicircular canal. These two characters, considered as ancestral features for Theria, might be symplesiomorphies of Euungulata as well. <i>Hyopsodus</i> and <i>Xenicohippus</i> share characters also observed in other basal Equoidea, which would support the close relationship between these two taxa previously proposed in the literature. A functional study of the cochlea of <i>Hyopsodus lepidus</i> is also realised to discuss its putative ability of using terrestrial echolocation previously proposed in the literature. The morphology of the cochlea of <i>Hyopsodus lepidus</i> does not indicate a specialisation to sophisticated echolocation such as observed today in microchiropteran bats. However, its estimated audible range of frequencies (208 Hz to 76.8 KHz) would be compatible with terrestrial echolocation.
DOI: 10.6084/m9.figshare.1030651.v1
title: Gaussian Job Archive for C20H20ClCuIN5

description: Archive of work produced using the resources of the Imperial College High Performance Computing Service.
DOI: 10.6084/m9.figshare.1031552.v2
title: The inner ear morphology of the ‘condylarthran’ <i>Hyopsodus lepidus</i>

description: We describe the bony labyrinth morphology of the Eocene ‘archaic ungulate’ <i>Hyopsodus</i><i>lepidus</i> (Bridgerian, North America) reconstructed from micro computed tomography scan data. Comparisons with the inner ear of the Eocene early diverging artiodactyl <i>Diacodexis</i> and perissodactyl <i>Xenicohippus</i> allow refining the picture of the ancestral inner ear morphology of Euungulates. These taxa are very close morphologically and mostly differ by slight differences in their semicircular canal angulations and profile. They all present a secondary crus and a low position of the plane of the lateral semicircular canal relative to the posterior semicircular canal. These two characters, considered as ancestral features for Theria, might be symplesiomorphies of Euungulata as well. <i>Hyopsodus</i> and <i>Xenicohippus</i> share characters also observed in other basal Equoidea, which would support the close relationship between these two taxa previously proposed in the literature. A functional study of the cochlea of <i>Hyopsodus lepidus</i> is also realised to discuss its putative ability of using terrestrial echolocation previously proposed in the literature. The morphology of the cochlea of <i>Hyopsodus lepidus</i> does not indicate a specialisation to sophisticated echolocation such as observed today in microchiropteran bats. However, its estimated audible range of frequencies (208 Hz to 76.8 KHz) would be compatible with terrestrial echolocation.
DOI: 10.6084/m9.figshare.1030647
title: Hart et al., APS poster

description: This is the Hart et al., poster from APS 2014
DOI: 10.6084/m9.figshare.1030649
title: Sponheimer et al. (2003) IJO Mammal Feed and Hair Nitrogen Isotope Data

description: Data from 2003 IJO paper
DOI: 10.6084/m9.figshare.1030647.v1
title: Hart et al., APS poster

description: This is the Hart et al., poster from APS 2014
DOI: 10.6084/m9.figshare.1031243.v1
title: Extending the Artificial Habitability Zone To Pluto?

description: This paper expands upon the idea of artificial habitability zones, by engineering a habitable environment for Pluto. It is meant to be a fun discussion paper and not subject to any intense theoretical scrutinty, though scrutinty is very much welcomed, as it will allow the paper to be further refined in the future.