DOI: 10.7937/k9/tcia.2016.nqf4gpn2
title: Data From QIN GBM Treatment Response

description: This collection contains “double baseline” multi-parametric MRI images collected on patients with newly diagnosed glioblastoma. The patients were scanned after surgery but prior to the start of therapy, typically 2-5 days apart. The structural images included T1-weighted pre- and post-contrast images, T2-weighted images, FLAIR and MEMPRAGE images. Advanced MRI sequences included Diffusion Weighted (DW) Imaging, Dynamic Contrast-Enhanced MRI (DCE-MRI), and Dynamic Susceptibility Contrast MRI (DSC-MRI). The value of this collection is to provide clinical image data to establish the test-retest characteristics of parameters calculated from DW-MRI, DCE-MRI, and DSC-MRI such as ADC, Ktrans and rCBV. Data were provided by Dr. Elizabeth Gerstner and Dr. Kalpathy-Cramer (MGH) as part of their participation in the Quantitative Imaging Network. The images were obtained on 32-channel Siemens Trio 3T scanners using Siemens 32-channel head coils. T1-weighted imaging was performed using a 2D FLASH sequence with TR/TE/α = 600 ms/12 ms/90°, matrix size 256 × 216, field of view (FOV ) 185mm × 220mm, 23 slices and 5mm slice thickness. T2-weighted imaging was performed using a 3D SPACE spin-echo sequence with TR/TE = 3200 ms/428 ms, matrix size 256 × 258, FOV 256mm × 256mm, 176 slices and 1mm slice thickness. FLAIR was performed using a 2D spin-echo inversion-recovery sequence with TR/TI/TE = 10000 ms/2500 ms/70 ms, matrix size 256 × 162, FOV 185mm × 220mm, 23 slices and 5mm slice thickness. MEMPRAGE was performed using a 3D multi-echo Magnetization Prepared Rapid Gradient Echo sequence with TR/TI/TE1/TE2/TE3/TE4/α =2530 ms/1200 ms/1.64 ms/3.5 ms/5.36 ms/7.22 ms/7°, matrix size 256 × 256, FOV 256mm × 256mm, 176 slices and 1mm slice thickness. A DW echo planar imaging sequence with trace diffusion sensitization and b-values of 0 and 700 s/mm2, TR/TE = 7980 ms/84 ms, matrix size 128 × 128, FOV 237mm × 237mm, 64 slices and 1.86mm slice thickness, provided data for Apparent Diffusion Coefficient (ADC) maps. To estimate pre-contrast T1 relaxation time for DCE quantitation purposes, T1 mapping was performed by using a 3D FLASH sequence before the injection of contrast agent with TR/TE = 7.3 ms/4.41 ms, matrix size 128 × 128, FOV 230mm × 230mm, 20 slices, and 2.1mm slice thickness. This sequence was repeated five times at five different flip-angles of 2°, 5°,10°,15°, and 30°. DCE MRI utilized a 3D FLASH dual gradient-echo sequence with with TR/TE1/TE2/α = 6.8 ms/2.61 ms/3.89 ms/10°, matrix size 128 × 128, FOV 230mm × 230mm, 20 slices and 2.1mm slice thickness. The acquisition was repeated for 60 times (frames) for a total scan time of 6 min, corresponding to a temporal resolution of 6 s. A bolus of 0.1 mmol/kg of Gd-DTPA (gadopentetic acid) was injected 52 s after the scan started. Finally, a combined gradient-echo (ge) and spin-echo (se) 2D EPI sequence was performed to acquire DSC-MRI data with TR/TE(ge)/TE(se)/α = 1500 ms/31 ms/95 ms/80°, matrix size 160 × 160, FOV 192mm × 192mm, 12 slices and 5mm slice thickness. The acquisition was repeated 100 times for a total scan time of 2 min and 41 sec, corresponding to a temporal resolution of 1.61 s. A bolus of 0.1 mmol/kg of GD-DTPA was injected 80 s after the scan started.