cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.14272/fkshoqtwuwcwtg-uhfffaoysa-n/chmo0000595
title: 13C nuclear magnetic resonance spectroscopy (13C NMR) ((4-acetyl-3-acetyloxyphenyl) acetate)
title: InChI=1S/C12H12O5/c1-7(13)11-5-4-10(16-8(2)14)6-12(11)17-9(3)15/h4-6H,1-3H3

description: dataset for 13C nuclear magnetic resonance spectroscopy (13C NMR)
 
 13C NMR (100 MHz, Chloroform-d [77.2 ppm], ppm) δ = 196.4 (Cq), 169.1 (Cq), 168.4 (Cq), 154.1 (Cq), 150.2 (Cq), 131.5 (CH), 128.2 (Cq), 119.2 (CH), 117.5 (CH), 29.5 (CH3), 21.2 (2C, CH3).
DOI: 10.14272/fkshoqtwuwcwtg-uhfffaoysa-n/chmo0000593
title: 1H nuclear magnetic resonance spectroscopy (1H NMR) ((4-acetyl-3-acetyloxyphenyl) acetate)
title: InChI=1S/C12H12O5/c1-7(13)11-5-4-10(16-8(2)14)6-12(11)17-9(3)15/h4-6H,1-3H3

description: dataset for 1H nuclear magnetic resonance spectroscopy (1H NMR)
 
 1H NMR (400 MHz, Chloroform-d [7.26 ppm], ppm) δ = 7.84 (d, J = 8.6 Hz, 1H), 7.09 (dd, J = 8.6 Hz, J = 2.1 Hz, 1H), 6.95 (d, J = 2.1 Hz, 1H), 2.53 (s, 3H), 2.33 (s, 3H), 2.29 (s, 3H).
DOI: 10.14272/fkshoqtwuwcwtg-uhfffaoysa-n/chmo0000601
title: heteronuclear multiple bond coherence (HMBC) ((4-acetyl-3-acetyloxyphenyl) acetate)
title: InChI=1S/C12H12O5/c1-7(13)11-5-4-10(16-8(2)14)6-12(11)17-9(3)15/h4-6H,1-3H3

description: dataset for heteronuclear multiple bond coherence (HMBC)
DOI: 10.14272/fkshoqtwuwcwtg-uhfffaoysa-n/chmo0000630
title: infrared absorption spectroscopy (IR) ((4-acetyl-3-acetyloxyphenyl) acetate)
title: InChI=1S/C12H12O5/c1-7(13)11-5-4-10(16-8(2)14)6-12(11)17-9(3)15/h4-6H,1-3H3

description: dataset for infrared absorption spectroscopy (IR)
 
 IR (ATR, ṽ) = 1765 (vs), 1684 (vs), 1604 (s), 1579 (m), 1490 (w), 1424 (w), 1412 (m), 1366 (s), 1303 (w), 1271 (w), 1248 (s), 1186 (vs), 1149 (vs), 1119 (vs), 1064 (s), 1045 (m), 1013 (vs), 982 (s), 953 (m), 909 (s), 841 (m), 823 (m), 779 (m), 739 (m), 670 (m), 640 (m), 591 (s), 552 (m), 507 (m), 443 (m), 415 (m), 409 (m), 402 (m), 390 (m) cm–1.
DOI: 10.14272/fkshoqtwuwcwtg-uhfffaoysa-n.1
title: (3-acetoxy-4-acetyl-phenyl) acetate
title: InChI=1S/C12H12O5/c1-7(13)11-5-4-10(16-8(2)14)6-12(11)17-9(3)15/h4-6H,1-3H3

description: This is a physical chemical entity[CHEBI_24431] associated with a molecule[CHEBI_25367].
 The molecule[CHEBI_25367] can be described by the following structural desciptors[cheminf_000085]:
 InChI descriptor[cheminf_000113]: InChI=1S/C12H12O5/c1-7(13)11-5-4-10(16-8(2)14)6-12(11)17-9(3)15/h4-6H,1-3H3, and canonical SMILES descriptor[cheminf_000007]: CC(=O)Oc1ccc(c(c1)OC(=O)C)C(=O)C, and by the IUPAC name[cheminf_000107]: (4-acetyl-3-acetyloxyphenyl) acetate.
 
 The physical chemical entity[CHEBI_24431] has a component solvent[CHEBI_46787] which is described by the canonical SMILES descriptor[cheminf_000007]:
 
 The physical chemical entity[CHEBI_24431] has the following Sample ID as registered in the research data repository chemotion (www.chemotion-repository.net, https://doi.org/10.25504/FAIRsharing.iagXcR): CRS-39932

 The physical chemical entity[CHEBI_24431] can be described by the physical descriptors [CHEMINF_000025]:
 Melting point descriptor[CHEMINF_000256]: 
 Boiling point descriptor[CHEMINF_000257]: 
 Refractive index descriptor[CHEMINF_000253]:

 The physical chemical entity[CHEBI_24431] can be further described by the following assays[OBI:0000070][CHMO:0001133]:
 
 CHMO:0000599 | correlation spectroscopy (COSY)
 
 CHMO:0000596 | distortionless enhancement with polarization transfer (DEPT)
 
 CHMO:0000596 | distortionless enhancement with polarization transfer (DEPT)
 
 CHMO:0000593 | 1H nuclear magnetic resonance spectroscopy (1H NMR)
 
 CHMO:0000595 | 13C nuclear magnetic resonance spectroscopy (13C NMR)
 
 CHMO:0000604 | heteronuclear single quantum coherence (HSQC)
 
 CHMO:0000601 | heteronuclear multiple bond coherence (HMBC)
 
 CHMO:0000630 | infrared absorption spectroscopy (IR)
 
 CHMO:0000470 | mass spectrometry (MS)
 
 The physical chemical entity[CHEBI_24431] was deposited to the Molecule Archive of the Karlsruhe Insitute of Technology (KIT) with the following Sample ID: 

 Used ontologies:
 CHEBI - Chemical Entities of Biological Interest
 CHEMINF - chemical information ontology (information entities about chemical entities)
 CHMO - Chemical Methods Ontology
 OBI - Ontology for Biomedical Investigations
DOI: 10.14272/fkshoqtwuwcwtg-uhfffaoysa-n/chmo0000599
title: correlation spectroscopy (COSY) ((4-acetyl-3-acetyloxyphenyl) acetate)
title: InChI=1S/C12H12O5/c1-7(13)11-5-4-10(16-8(2)14)6-12(11)17-9(3)15/h4-6H,1-3H3

description: dataset for correlation spectroscopy (COSY)
DOI: 10.14272/nvnlhlrvshjkbn-uhfffaoysa-n/chmo0000596
title: distortionless enhancement with polarization transfer (DEPT) (3-chloro-5-(trifluoromethyl)benzene-1,2-diamine)
title: InChI=1S/C7H6ClF3N2/c8-4-1-3(7(9,10)11)2-5(12)6(4)13/h1-2H,12-13H2

description: dataset for distortionless enhancement with polarization transfer (DEPT)
DOI: 10.14272/nvnlhlrvshjkbn-uhfffaoysa-n/chmo0000597
title: 19F nuclear magnetic resonance spectroscopy (19F NMR) (3-chloro-5-(trifluoromethyl)benzene-1,2-diamine)
title: InChI=1S/C7H6ClF3N2/c8-4-1-3(7(9,10)11)2-5(12)6(4)13/h1-2H,12-13H2

description: dataset for 19F nuclear magnetic resonance spectroscopy (19F NMR)
 
 19F NMR (376 MHz, ppm) δ = -61.64.
DOI: 10.14272/nvnlhlrvshjkbn-uhfffaoysa-n/chmo0000601
title: heteronuclear multiple bond coherence (HMBC) (3-chloro-5-(trifluoromethyl)benzene-1,2-diamine)
title: InChI=1S/C7H6ClF3N2/c8-4-1-3(7(9,10)11)2-5(12)6(4)13/h1-2H,12-13H2

description: dataset for heteronuclear multiple bond coherence (HMBC)
DOI: 10.14272/nvnlhlrvshjkbn-uhfffaoysa-n/chmo0000604
title: heteronuclear single quantum coherence (HSQC) (3-chloro-5-(trifluoromethyl)benzene-1,2-diamine)
title: InChI=1S/C7H6ClF3N2/c8-4-1-3(7(9,10)11)2-5(12)6(4)13/h1-2H,12-13H2

description: dataset for heteronuclear single quantum coherence (HSQC)
DOI: 10.14272/nvnlhlrvshjkbn-uhfffaoysa-n/chmo0000630
title: infrared absorption spectroscopy (IR) (3-chloro-5-(trifluoromethyl)benzene-1,2-diamine)
title: InChI=1S/C7H6ClF3N2/c8-4-1-3(7(9,10)11)2-5(12)6(4)13/h1-2H,12-13H2

description: dataset for infrared absorption spectroscopy (IR)
 
 IR (ATR, ṽ) = 3431 (w), 3354 (w), 1628 (s), 1582 (m), 1507 (w), 1439 (s), 1357 (m), 1329 (vs), 1300 (m), 1230 (s), 1156 (vs), 1103 (vs), 936 (s), 851 (vs), 771 (m), 749 (m), 710 (s), 677 (vs), 653 (s), 629 (s), 557 (s), 535 (s), 520 (s), 503 (s), 425 (m), 404 (s) cm–1.
DOI: 10.14272/nvnlhlrvshjkbn-uhfffaoysa-n/chmo0000595
title: 13C nuclear magnetic resonance spectroscopy (13C NMR) (3-chloro-5-(trifluoromethyl)benzene-1,2-diamine)
title: InChI=1S/C7H6ClF3N2/c8-4-1-3(7(9,10)11)2-5(12)6(4)13/h1-2H,12-13H2

description: dataset for 13C nuclear magnetic resonance spectroscopy (13C NMR)
 
 13C NMR (100 MHz, Chloroform-d [77.2 ppm], ppm) δ = 135.5 (Cq), 135.0 (Cq), 124.1 (q, J = 271.3 Hz, CF3), 121.5 (q, J = 33.1 Hz, Cq), 119.9 (Cq), 118.0 (q, J = 3.9 Hz, CH), 111.8 (q, J = 3.5 Hz, CH).
DOI: 10.14272/nvnlhlrvshjkbn-uhfffaoysa-n/chmo0000470
title: mass spectrometry (MS) (3-chloro-5-(trifluoromethyl)benzene-1,2-diamine)
title: InChI=1S/C7H6ClF3N2/c8-4-1-3(7(9,10)11)2-5(12)6(4)13/h1-2H,12-13H2

description: dataset for mass spectrometry (MS)
 
 MS (EI, 70 eV, 20 °C), m/z (%): 210/212 (100/30) [M]+. HRMS–EI (C7H6N2ClF3) (m/z): [M]+ Calcd 210.0166; Found 210.0165.
DOI: 10.14272/nvnlhlrvshjkbn-uhfffaoysa-n/chmo0000599
title: correlation spectroscopy (COSY) (3-chloro-5-(trifluoromethyl)benzene-1,2-diamine)
title: InChI=1S/C7H6ClF3N2/c8-4-1-3(7(9,10)11)2-5(12)6(4)13/h1-2H,12-13H2

description: dataset for correlation spectroscopy (COSY)
DOI: 10.14272/nvnlhlrvshjkbn-uhfffaoysa-n/chmo0000596.1
title: distortionless enhancement with polarization transfer (DEPT) (3-chloro-5-(trifluoromethyl)benzene-1,2-diamine)
title: InChI=1S/C7H6ClF3N2/c8-4-1-3(7(9,10)11)2-5(12)6(4)13/h1-2H,12-13H2

description: dataset for distortionless enhancement with polarization transfer (DEPT)
DOI: 10.14272/nvnlhlrvshjkbn-uhfffaoysa-n.1
title: 3-chloro-5-(trifluoromethyl)benzene-1,2-diamine
title: InChI=1S/C7H6ClF3N2/c8-4-1-3(7(9,10)11)2-5(12)6(4)13/h1-2H,12-13H2

description: This is a physical chemical entity[CHEBI_24431] associated with a molecule[CHEBI_25367].
 The molecule[CHEBI_25367] can be described by the following structural desciptors[cheminf_000085]:
 InChI descriptor[cheminf_000113]: InChI=1S/C7H6ClF3N2/c8-4-1-3(7(9,10)11)2-5(12)6(4)13/h1-2H,12-13H2, and canonical SMILES descriptor[cheminf_000007]: Nc1cc(cc(c1N)Cl)C(F)(F)F, and by the IUPAC name[cheminf_000107]: 3-chloro-5-(trifluoromethyl)benzene-1,2-diamine.
 
 The physical chemical entity[CHEBI_24431] has a component solvent[CHEBI_46787] which is described by the canonical SMILES descriptor[cheminf_000007]:
 
 The physical chemical entity[CHEBI_24431] has the following Sample ID as registered in the research data repository chemotion (www.chemotion-repository.net, https://doi.org/10.25504/FAIRsharing.iagXcR): CRS-39921

 The physical chemical entity[CHEBI_24431] can be described by the physical descriptors [CHEMINF_000025]:
 Melting point descriptor[CHEMINF_000256]: 
 Boiling point descriptor[CHEMINF_000257]: 
 Refractive index descriptor[CHEMINF_000253]:

 The physical chemical entity[CHEBI_24431] can be further described by the following assays[OBI:0000070][CHMO:0001133]:
 
 CHMO:0000593 | 1H nuclear magnetic resonance spectroscopy (1H NMR)
 
 CHMO:0000596 | distortionless enhancement with polarization transfer (DEPT)
 
 CHMO:0000599 | correlation spectroscopy (COSY)
 
 CHMO:0000604 | heteronuclear single quantum coherence (HSQC)
 
 CHMO:0000601 | heteronuclear multiple bond coherence (HMBC)
 
 CHMO:0000597 | 19F nuclear magnetic resonance spectroscopy (19F NMR)
 
 CHMO:0000596 | distortionless enhancement with polarization transfer (DEPT)
 
 CHMO:0000595 | 13C nuclear magnetic resonance spectroscopy (13C NMR)
 
 CHMO:0000630 | infrared absorption spectroscopy (IR)
 
 CHMO:0000470 | mass spectrometry (MS)
 
 The physical chemical entity[CHEBI_24431] was deposited to the Molecule Archive of the Karlsruhe Insitute of Technology (KIT) with the following Sample ID: 

 Used ontologies:
 CHEBI - Chemical Entities of Biological Interest
 CHEMINF - chemical information ontology (information entities about chemical entities)
 CHMO - Chemical Methods Ontology
 OBI - Ontology for Biomedical Investigations
DOI: 10.5285/14039a6f-cf47-3c3b-e063-6c86abc0c05d
title: Microcat-ODO data (Temperature, Salinity, Pressure and Dissolved Oxygen) from mooring RTEB1 of the Eastern Boundary array (Rockall Trough), as part of UK OSNAP (Overturning in the Subpolar North Atlantic Programme) from May 2017 to July 2018.

description: The dataset consists of data (Temperature, Salinity, Pressure and Dissolved Oxygen) collected by moored CTD-DO instruments (microcat-ODO) in the eastern Rockall Trough between May 2017 and July 2018. The moored CTD-DO instruments were situated at various depths on mooring RTEB1 which is the easternmost mooring of the Atlantic-wide OSNAP mooring array. The CTD-DO instruments were deployed on cruise DY078 (2017) and recovered on AR30-04 (2018). The data have been processed and calibrated. Mooring RTEB1 is deployed under UK OSNAP (NE/K010875/1 and NE/K010875/2). The CTD-DO instruments were funded by the European Union's Horizon 2020 Research and Innovation Programme under grant agreement nos. 678760 (ATLAS), 818123 (iAtlantic) and 633211 (AtlantOS).
DOI: 10.6084/m9.figshare.14413525
title: Augmenting ATG14 alleviates atherosclerosis and inhibits inflammation via promotion of autophagosome-lysosome fusion in macrophages

description: Dysfunction of macroautophagy/autophagy in macrophages contributes to atherosclerosis. Impaired autophagy-lysosomal degradation system leads to lipid accumulation, facilitating atherosclerotic plaque. ATG14 is an essential regulator for the fusion of autophagosomes with lysosomes. Whether ATG14 plays a role in macrophage autophagy dysfunction in atherosclerosis is unknown. To investigate the effects of ATG14 on macrophage autophagy, human atherosclerotic plaque, <i>apoe<sup>−/-</sup></i> mice and cultured mouse macrophages were evaluated. Overexpression of ATG14 by adenovirus was used to reveal its function in autophagy, inflammation and atherosclerotic plaque formation. Results showed that impaired autophagy function with reduction of ATG14 expression existed in macrophages of human and mouse atherosclerotic plaques. Ox-LDL impaired autophagosome-lysosome fusion with reduction of ATG14 expression in macrophages. Overexpression of ATG14 in macrophages enhanced fusion of autophagosomes with lysosomes and promoted lipid degradation, decreasing Ox-LDL-induced apoptosis and inflammatory response. Augmenting ATG14 expression reversed the autophagy dysfunction in macrophages of <i>apoe<sup>−/-</sup></i> mice plaque, blunted SQSTM1/p62 accumulation, inhibited inflammation, and upregulated the population of Treg cells, resulting in alleviating atherosclerotic lesions. <b>Abbreviations:</b> ABCC1: ATP-binding cassette, sub-family C (CFTR/MRP), member 1; ABCA1: ATP-binding cassette, sub-family A (ABC1), member 1; Ad-<i>Atg14</i>: adenovirus vector carrying the mouse <i>Atg14</i> gene; Ad-<i>LacZ</i>: adenovirus vector carrying the gene for bacterial β-galactosidase; <i>apoe<sup>−/-</sup></i>: apolipoprotein E knockout; ATG14: autophagy-related 14; CD68: CD68 antigen; DAPI: 4ʹ,6-diamidino-2-phenylindole; Dil-ox-LDL: Dil-oxidized low density lipoprotein; ELISA: enzyme-linked immunosorbent assay; HFD: high-fat diet (an atherogenic diet); IL: interleukin; LAMP2: lysosomal-associated membrane protein 2; LDL-C: low density lipoprotrein cholesterol; MAP1LC3/LC3: microtubule-associated protein 1 light chain 3; ND: normal diet; Ox-LDL: oxidized low density lipoprotein; PBMC: peripheral blood mononuclear cells; SQSTM1/p62: sequestosome 1; SREBF1/SREBP1c: sterol regulatory element binding transcription factor 1; SREBF2/SREBP2: sterol regulatory element binding factor 2; STX17: syntaxin 17; TC: serum total cholesterol; TG: triglyceride; TNF: tumor necrosis factor; IFN: interferon; Treg cell: regulatory T cell
DOI: 10.6084/m9.figshare.14413525.v1
title: Augmenting ATG14 alleviates atherosclerosis and inhibits inflammation via promotion of autophagosome-lysosome fusion in macrophages

description: Dysfunction of macroautophagy/autophagy in macrophages contributes to atherosclerosis. Impaired autophagy-lysosomal degradation system leads to lipid accumulation, facilitating atherosclerotic plaque. ATG14 is an essential regulator for the fusion of autophagosomes with lysosomes. Whether ATG14 plays a role in macrophage autophagy dysfunction in atherosclerosis is unknown. To investigate the effects of ATG14 on macrophage autophagy, human atherosclerotic plaque, <i>apoe<sup>−/-</sup></i> mice and cultured mouse macrophages were evaluated. Overexpression of ATG14 by adenovirus was used to reveal its function in autophagy, inflammation and atherosclerotic plaque formation. Results showed that impaired autophagy function with reduction of ATG14 expression existed in macrophages of human and mouse atherosclerotic plaques. Ox-LDL impaired autophagosome-lysosome fusion with reduction of ATG14 expression in macrophages. Overexpression of ATG14 in macrophages enhanced fusion of autophagosomes with lysosomes and promoted lipid degradation, decreasing Ox-LDL-induced apoptosis and inflammatory response. Augmenting ATG14 expression reversed the autophagy dysfunction in macrophages of <i>apoe<sup>−/-</sup></i> mice plaque, blunted SQSTM1/p62 accumulation, inhibited inflammation, and upregulated the population of Treg cells, resulting in alleviating atherosclerotic lesions. <b>Abbreviations:</b> ABCC1: ATP-binding cassette, sub-family C (CFTR/MRP), member 1; ABCA1: ATP-binding cassette, sub-family A (ABC1), member 1; Ad-<i>Atg14</i>: adenovirus vector carrying the mouse <i>Atg14</i> gene; Ad-<i>LacZ</i>: adenovirus vector carrying the gene for bacterial β-galactosidase; <i>apoe<sup>−/-</sup></i>: apolipoprotein E knockout; ATG14: autophagy-related 14; CD68: CD68 antigen; DAPI: 4ʹ,6-diamidino-2-phenylindole; Dil-ox-LDL: Dil-oxidized low density lipoprotein; ELISA: enzyme-linked immunosorbent assay; HFD: high-fat diet (an atherogenic diet); IL: interleukin; LAMP2: lysosomal-associated membrane protein 2; LDL-C: low density lipoprotrein cholesterol; MAP1LC3/LC3: microtubule-associated protein 1 light chain 3; ND: normal diet; Ox-LDL: oxidized low density lipoprotein; PBMC: peripheral blood mononuclear cells; SQSTM1/p62: sequestosome 1; SREBF1/SREBP1c: sterol regulatory element binding transcription factor 1; SREBF2/SREBP2: sterol regulatory element binding factor 2; STX17: syntaxin 17; TC: serum total cholesterol; TG: triglyceride; TNF: tumor necrosis factor; IFN: interferon; Treg cell: regulatory T cell
DOI: 10.6084/m9.figshare.14308828
title: Long noncoding RNA (lncRNA) <i>EIF3J-DT</i> induces chemoresistance of gastric cancer via autophagy activation

description: Chemotherapy is currently the main treatment for unresectable or advanced postoperative gastric cancers. However, its efficacy is negatively affected by the occurrence of chemoresistance, which severely affects patient prognosis. Recently, dysregulation in autophagy has been suggested as a potential mechanism for chemoresistence, and long noncoding RNA (lncRNA) also shows its regulatory role in cancer drug resistance. Using RNA sequencing, we found that lncRNA <i>EIF3J-DT</i> was highly expressed in drug-resistant gastric cancer cells. In-vitro and in-vivo experiments showed that <i>EIF3J-DT</i> activated autophagy and induced drug resistance in gastric cancer cells by targeting ATG14. Bioinformatics and experimental results showed that <i>EIF3J-DT</i> regulated the expression of ATG14 through direct binding to enhance stabilization of <i>ATG14</i> mRNA and via blocking the degradation of <i>ATG14</i> mRNA through competitively binding with microRNA (miRNA) <i>MIR188-3p</i>. Therefore, <i>EIF3J-DT</i> increased the expression of ATG14, contributing to activation of autophagy and chemoresistance. Furthermore, it was confirmed that <i>EIF3J-DT</i> and ATG14 were highly expressed in gastric cancer patients resistant to chemotherapy, and this was closely associated with patient prognosis. In conclusion, <i>EIF3J-DT</i> is involved in the regulation of autophagy and chemoresistance in gastric cancer cells by targeting ATG14. It may be a suitable new target for enhancing chemosensitivity and improving prognosis. <b>Abbreviations:</b> 3-MA: 3-methyladenine; 5-Fu: 5-fluorouracil; ATG: autophagy related; C-CASP3: cleaved caspase 3; C-CASP7: cleaved caspase 7; C-PARP: cleaved PARP; CQ: chloroquine; CR: complete response; DIG: digoxigenin; ESR1: estrogen receptor 1; FBS: fetal bovine serum; FISH: fluorescence in situ hybridization; IHC: immunohistochemistry; ISH: in situ hybridization; lncRNA: long noncoding RNA; miRNA: microRNA; MUT: mutant; NC: negative control; OXA: oxaliplatin; PBS: phosphate-buffered saline; PD: progressive disease; PFA: paraformaldehyde; PR: partial response; qPCR: quantitative polymerase chain reaction; RAPA: rapamycin; SD: stable disease; TEM: transmission electron microscopy; WT: wild type.
DOI: 10.6084/m9.figshare.14308828.v1
title: Long noncoding RNA (lncRNA) <i>EIF3J-DT</i> induces chemoresistance of gastric cancer via autophagy activation

description: Chemotherapy is currently the main treatment for unresectable or advanced postoperative gastric cancers. However, its efficacy is negatively affected by the occurrence of chemoresistance, which severely affects patient prognosis. Recently, dysregulation in autophagy has been suggested as a potential mechanism for chemoresistence, and long noncoding RNA (lncRNA) also shows its regulatory role in cancer drug resistance. Using RNA sequencing, we found that lncRNA <i>EIF3J-DT</i> was highly expressed in drug-resistant gastric cancer cells. In-vitro and in-vivo experiments showed that <i>EIF3J-DT</i> activated autophagy and induced drug resistance in gastric cancer cells by targeting ATG14. Bioinformatics and experimental results showed that <i>EIF3J-DT</i> regulated the expression of ATG14 through direct binding to enhance stabilization of <i>ATG14</i> mRNA and via blocking the degradation of <i>ATG14</i> mRNA through competitively binding with microRNA (miRNA) <i>MIR188-3p</i>. Therefore, <i>EIF3J-DT</i> increased the expression of ATG14, contributing to activation of autophagy and chemoresistance. Furthermore, it was confirmed that <i>EIF3J-DT</i> and ATG14 were highly expressed in gastric cancer patients resistant to chemotherapy, and this was closely associated with patient prognosis. In conclusion, <i>EIF3J-DT</i> is involved in the regulation of autophagy and chemoresistance in gastric cancer cells by targeting ATG14. It may be a suitable new target for enhancing chemosensitivity and improving prognosis. <b>Abbreviations:</b> 3-MA: 3-methyladenine; 5-Fu: 5-fluorouracil; ATG: autophagy related; C-CASP3: cleaved caspase 3; C-CASP7: cleaved caspase 7; C-PARP: cleaved PARP; CQ: chloroquine; CR: complete response; DIG: digoxigenin; ESR1: estrogen receptor 1; FBS: fetal bovine serum; FISH: fluorescence in situ hybridization; IHC: immunohistochemistry; ISH: in situ hybridization; lncRNA: long noncoding RNA; miRNA: microRNA; MUT: mutant; NC: negative control; OXA: oxaliplatin; PBS: phosphate-buffered saline; PD: progressive disease; PFA: paraformaldehyde; PR: partial response; qPCR: quantitative polymerase chain reaction; RAPA: rapamycin; SD: stable disease; TEM: transmission electron microscopy; WT: wild type.