cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.3990384
title: Supplementary Material for: Redistribution of NMDA Receptors in Estrogen-Receptor-β-Containing Paraventricular Hypothalamic Neurons following Slow-Pressor Angiotensin II Hypertension in Female Mice with Accelerated Ovarian Failure

description: Hypertension in male and aging female rodents is associated with glutamate-dependent plasticity in the hypothalamus, but existing models have failed to capture distinct transitional menopausal phases that could have a significant impact on the synaptic plasticity and emergent hypertension. In rodents, accelerated ovarian failure (AOF) induced by systemic injection of 4-vinylcyclohexane diepoxide mimics the estrogen fluctuations seen in human menopause including the perimenopause transition (peri-AOF) and postmenopause (post-AOF). Thus, we used the mouse AOF model to determine the impact of slow-pressor angiotensin II (AngII) administration on blood pressure and on the subcellular distribution of obligatory N-methyl-D-aspartate (NMDA) receptor GluN1 subunits in the paraventricular hypothalamic nucleus (PVN), a key estrogen-responsive cardiovascular regulatory area. Estrogen-sensitive neuronal profiles were identified in mice expressing enhanced green fluorescent protein under the promoter for estrogen receptor (ER) β, a major ER in the PVN. Slow-pressor AngII increased arterial blood pressure in mice at peri- and post-AOF time points. In control oil-injected (nonhypertensive) mice, AngII decreased the total number of GluN1 in ERβ-containing PVN dendrites. In contrast, AngII resulted in a reapportionment of GluN1 from the cytoplasm to the plasma membrane of ERβ-containing PVN dendrites in peri-AOF mice. Moreover, in post-AOF mice, AngII increased total GluN1, dendritic size and radical production in ERβ-containing neurons. These results indicate that unique patterns of hypothalamic glutamate receptor plasticity and dendritic structure accompany the elevated blood pressure in peri- and post-AOF time points. Our findings suggest the possibility that distinct neurobiological processes are associated with the increased blood pressure during perimenopausal and postmenopausal periods.
DOI: 10.6084/m9.figshare.3990384.v1
title: Supplementary Material for: Redistribution of NMDA Receptors in Estrogen-Receptor-β-Containing Paraventricular Hypothalamic Neurons following Slow-Pressor Angiotensin II Hypertension in Female Mice with Accelerated Ovarian Failure

description: Hypertension in male and aging female rodents is associated with glutamate-dependent plasticity in the hypothalamus, but existing models have failed to capture distinct transitional menopausal phases that could have a significant impact on the synaptic plasticity and emergent hypertension. In rodents, accelerated ovarian failure (AOF) induced by systemic injection of 4-vinylcyclohexane diepoxide mimics the estrogen fluctuations seen in human menopause including the perimenopause transition (peri-AOF) and postmenopause (post-AOF). Thus, we used the mouse AOF model to determine the impact of slow-pressor angiotensin II (AngII) administration on blood pressure and on the subcellular distribution of obligatory N-methyl-D-aspartate (NMDA) receptor GluN1 subunits in the paraventricular hypothalamic nucleus (PVN), a key estrogen-responsive cardiovascular regulatory area. Estrogen-sensitive neuronal profiles were identified in mice expressing enhanced green fluorescent protein under the promoter for estrogen receptor (ER) β, a major ER in the PVN. Slow-pressor AngII increased arterial blood pressure in mice at peri- and post-AOF time points. In control oil-injected (nonhypertensive) mice, AngII decreased the total number of GluN1 in ERβ-containing PVN dendrites. In contrast, AngII resulted in a reapportionment of GluN1 from the cytoplasm to the plasma membrane of ERβ-containing PVN dendrites in peri-AOF mice. Moreover, in post-AOF mice, AngII increased total GluN1, dendritic size and radical production in ERβ-containing neurons. These results indicate that unique patterns of hypothalamic glutamate receptor plasticity and dendritic structure accompany the elevated blood pressure in peri- and post-AOF time points. Our findings suggest the possibility that distinct neurobiological processes are associated with the increased blood pressure during perimenopausal and postmenopausal periods.
DOI: 10.7910/dvn/v1rjpf/yemoqb
title: snk20160618_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.3990372
title: Supplementary Material for: Arthrogryposis as a Syndrome: Gene Ontology Analysis

description: Arthrogryposis by definition has multiple congenital contractures. All types of arthrogryposis have decreased in utero fetal movement. Because so many things are involved in normal fetal movement, there are many causes and processes that can go awry. In this era of molecular genetics, we have tried to place the known mutated genes seen in genetic forms of arthrogryposis into biological processes or cellular functions as defined by gene ontology. We hope this leads to better identification of all interacting pathways and processes involved in the development of fetal movement in order to improve diagnosis of the genetic forms of arthrogryposis, to lead to the development of molecular therapies, and to help better define the natural history of various types of arthrogryposis.
DOI: 10.6084/m9.figshare.3990372.v1
title: Supplementary Material for: Arthrogryposis as a Syndrome: Gene Ontology Analysis

description: Arthrogryposis by definition has multiple congenital contractures. All types of arthrogryposis have decreased in utero fetal movement. Because so many things are involved in normal fetal movement, there are many causes and processes that can go awry. In this era of molecular genetics, we have tried to place the known mutated genes seen in genetic forms of arthrogryposis into biological processes or cellular functions as defined by gene ontology. We hope this leads to better identification of all interacting pathways and processes involved in the development of fetal movement in order to improve diagnosis of the genetic forms of arthrogryposis, to lead to the development of molecular therapies, and to help better define the natural history of various types of arthrogryposis.
DOI: 10.7910/dvn/v1rjpf/btz64c
title: snk20150722_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.3988986
title: Supplementary Material for: Karyotype and Mapping of Repetitive DNAs in the African Butterfly Fish Pantodon buchholzi, the Sole Species of the Family Pantodontidae

description: The monophyletic order Osteoglossiformes represents one of the most ancestral groups of teleosts and has at least 1 representative in all continents of the southern hemisphere, with the exception of Antarctica. However, despite its phylogenetic and biogeographical importance, cytogenetic data in Osteoglossiformes are scarce. Here, karyotype and chromosomal characteristics of the lower Niger River population of the African butterfly fish <i>Pantodon buchholzi</i>, the sole species of the family Pantodontidae (Osteoglossiformes), were examined using conventional and molecular cytogenetic approaches. All specimens examined had 2n = 46 chromosomes, with a karyotype composed of 5 pairs of metacentric, 5 pairs of submetacentric, and 13 pairs of acrocentric chromosomes in both sexes. No morphologically differentiated sex chromosomes were identified. C-bands were located in the centromeric/pericentromeric region of all chromosomes and were associated with the single AgNOR site. FISH with ribosomal DNA probes revealed that both 5S and 18S rDNA were present in only 1 pair of chromosomes each, but did not colocalize. CMA<sub>3</sub><sup>+</sup> bands were observed near the telomeres in several chromosome pairs and also at the 18S rDNA sites. The mapping of di- and trinucleotide repeat motifs, <i>Rex6</i> transposable element, and U2 snRNA showed a scattered distribution over most of the chromosomes, but for some microsatellites and the U2 snRNA also a preferential accumulation at telomeric regions. This study presents the first detailed cytogenetic analysis in the African butterfly fish by both conventional and molecular cytogenetic protocols. This is the first of a series of further cytogenetic and cytogenomic studies on osteoglossiforms, aiming to comprehensively examine the chromosomal evolution in this phylogenetically important fish order.
DOI: 10.7910/dvn/v1rjpf/qycf6w
title: snk20150318_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/gqv4my
title: snk20150523_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.3988968
title: <i>H</i><sub>∞</sub> control of continuous-time Markov jump linear systems with detector-based mode information<sup>†</sup>

description: This paper features new results on <i>H</i><sub>∞</sub> analysis and control of linear systems with Markov jump disturbances, in a scenario of partial observations of the jump process. We consider the situations in which the jump process can only be measured through a suitable <i>detector</i>. A distinctive feature of the approach here is that it is general enough to encompass particular scenarios such as that of perfect information, no information (mode independent) and cluster observations of the Markov jump process. The main results, comprising a new bounded real lemma and a condition for state feedback synthesis, are expressed via linear matrix inequality-based optimisation problems. The method devised for the design of <i>H</i><sub>∞</sub> controllers is applied to the control of an unmanned aerial vehicle model.
DOI: 10.6084/m9.figshare.3988968.v1
title: <i>H</i><sub>∞</sub> control of continuous-time Markov jump linear systems with detector-based mode information<sup>†</sup>

description: This paper features new results on <i>H</i><sub>∞</sub> analysis and control of linear systems with Markov jump disturbances, in a scenario of partial observations of the jump process. We consider the situations in which the jump process can only be measured through a suitable <i>detector</i>. A distinctive feature of the approach here is that it is general enough to encompass particular scenarios such as that of perfect information, no information (mode independent) and cluster observations of the Markov jump process. The main results, comprising a new bounded real lemma and a condition for state feedback synthesis, are expressed via linear matrix inequality-based optimisation problems. The method devised for the design of <i>H</i><sub>∞</sub> controllers is applied to the control of an unmanned aerial vehicle model.
DOI: 10.7910/dvn/v1rjpf/lners9
title: snk20150629_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/froerl
title: snk20160829_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/wez2zj
title: snk20150217_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/dhyfi5
title: snk20151113_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/vdoyul
title: snk20150826_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.3988902
title: A new formulation of slight compressibility for arterial tissue and its Finite Element implementation

description: In order to avoid the numerical difficulties in locally enforcing the incompressibility constraint using the displacement formulation of the Finite Element Method, slight compressibility is typically assumed when simulating the mechanical response of arterial tissue. The current standard method of accounting for slight compressibility of hyperelastic soft tissue assumes an additive decomposition of the strain-energy function into a volumetric and a deviatoric part. This has been shown, however, to be inconsistent with the linear theory and results in cubes retaining their cuboid shape under hydrostatic tension and compression, which seems at variance with the reinforcement of arterial tissue with two families of collagen fibres. A remedy for these defects is proposed here, a solution which generalises the current standard model of slight compressibility to include two additional terms, one of which is quadratic in the invariants and the other quadratic in . Experimental data are used to motivate typical values for the associated material constants of these additional terms. Some simulations are performed to allow contrasts and comparisons to be made between the current standard model of slight compressibility and its generalisation proposed here.
DOI: 10.7910/dvn/v1rjpf/gyzumo
title: snk20150904_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.3988902.v2
title: A new formulation of slight compressibility for arterial tissue and its Finite Element implementation

description: In order to avoid the numerical difficulties in locally enforcing the incompressibility constraint using the displacement formulation of the Finite Element Method, slight compressibility is typically assumed when simulating the mechanical response of arterial tissue. The current standard method of accounting for slight compressibility of hyperelastic soft tissue assumes an additive decomposition of the strain-energy function into a volumetric and a deviatoric part. This has been shown, however, to be inconsistent with the linear theory and results in cubes retaining their cuboid shape under hydrostatic tension and compression, which seems at variance with the reinforcement of arterial tissue with two families of collagen fibres. A remedy for these defects is proposed here, a solution which generalises the current standard model of slight compressibility to include two additional terms, one of which is quadratic in the invariants and the other quadratic in . Experimental data are used to motivate typical values for the associated material constants of these additional terms. Some simulations are performed to allow contrasts and comparisons to be made between the current standard model of slight compressibility and its generalisation proposed here.
DOI: 10.7910/dvn/v1rjpf/9kncy6
title: snk20160929_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.3988902.v1
title: A new formulation of slight compressibility for arterial tissue and its Finite Element implementation

description: In order to avoid the numerical difficulties in locally enforcing the incompressibility constraint using the displacement formulation of the Finite Element Method, slight compressibility is typically assumed when simulating the mechanical response of arterial tissue. The current standard method of accounting for slight compressibility of hyperelastic soft tissue assumes an additive decomposition of the strain-energy function into a volumetric and a deviatoric part. This has been shown, however, to be inconsistent with the linear theory and results in cubes retaining their cuboid shape under hydrostatic tension and compression, which seems at variance with the reinforcement of arterial tissue with two families of collagen fibres. A remedy for these defects is proposed here, a solution which generalises the current standard model of slight compressibility to include two additional terms, one of which is quadratic in the invariants and the other quadratic in . Experimental data are used to motivate typical values for the associated material constants of these additional terms. Some simulations are performed to allow contrasts and comparisons to be made between the current standard model of slight compressibility and its generalisation proposed here.
DOI: 10.7910/dvn/v1rjpf/fhb1iv
title: snk20150420_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.3988881
title: <i>N</i>-tuple topological/geometric cutoffs for 3D <i>N</i>-linear algebraic molecular codifications: variability, linear independence and QSAR analysis

description: Novel <i>N</i>-tuple topological/geometric cutoffs to consider specific inter-atomic relations in the QuBiLS-MIDAS framework are introduced in this manuscript. These molecular cutoffs permit the taking into account of relations between more than two atoms by using (dis-)similarity multi-metrics and the concepts related with topological and Euclidean-geometric distances. To this end, the <i>k</i>th two-, three- and four-tuple topological and geometric neighbourhood quotient (NQ) total (or local-fragment) spatial-(dis)similarity matrices are defined, to represent 3D information corresponding to the relations between two, three and four atoms of the molecular structures that satisfy certain cutoff criteria. First, an analysis of a diverse chemical space for the most common values of topological/Euclidean-geometric distances, bond/dihedral angles, triangle/quadrilateral perimeters, triangle area and volume was performed in order to determine the intervals to take into account in the cutoff procedures. A variability analysis based on Shannon’s entropy reveals that better distribution patterns are attained with the descriptors based on the cutoffs proposed (QuBiLS-MIDAS NQ-MDs) with regard to the results obtained when all inter-atomic relations are considered (QuBiLS-MIDAS KA-MDs – ‘Keep All’). A principal component analysis shows that the novel molecular cutoffs codify chemical information captured by the respective QuBiLS-MIDAS KA-MDs, as well as information not captured by the latter. Lastly, a QSAR study to obtain deeper knowledge of the contribution of the proposed methods was carried out, using four molecular datasets (steroids (STER), angiotensin converting enzyme (ACE), thermolysin inhibitors (THER) and thrombin inhibitors (THR)) widely used as benchmarks in the evaluation of several methodologies. One to four variable QSAR models based on multiple linear regression were developed for each compound dataset following the original division into training and test sets. The results obtained reveal that the novel cutoff procedures yield superior performances relative to those of the QuBiLS-MIDAS KA-MDs in the prediction of the biological activities considered. From the results achieved, it can be suggested that the proposed <i>N</i>-tuple topological/geometric cutoffs constitute a relevant criteria for generating MDs codifying particular atomic relations, ultimately useful in enhancing the modelling capacity of the QuBiLS-MIDAS 3D-MDs.
DOI: 10.6084/m9.figshare.3988863
title: ORCID Tutorial for Indonesian Researcher

description: This is ORCID tutorial in Indonesian Languange for lecturer and researcher.<br>
DOI: 10.6084/m9.figshare.3988881.v1
title: <i>N</i>-tuple topological/geometric cutoffs for 3D <i>N</i>-linear algebraic molecular codifications: variability, linear independence and QSAR analysis

description: Novel <i>N</i>-tuple topological/geometric cutoffs to consider specific inter-atomic relations in the QuBiLS-MIDAS framework are introduced in this manuscript. These molecular cutoffs permit the taking into account of relations between more than two atoms by using (dis-)similarity multi-metrics and the concepts related with topological and Euclidean-geometric distances. To this end, the <i>k</i>th two-, three- and four-tuple topological and geometric neighbourhood quotient (NQ) total (or local-fragment) spatial-(dis)similarity matrices are defined, to represent 3D information corresponding to the relations between two, three and four atoms of the molecular structures that satisfy certain cutoff criteria. First, an analysis of a diverse chemical space for the most common values of topological/Euclidean-geometric distances, bond/dihedral angles, triangle/quadrilateral perimeters, triangle area and volume was performed in order to determine the intervals to take into account in the cutoff procedures. A variability analysis based on Shannon’s entropy reveals that better distribution patterns are attained with the descriptors based on the cutoffs proposed (QuBiLS-MIDAS NQ-MDs) with regard to the results obtained when all inter-atomic relations are considered (QuBiLS-MIDAS KA-MDs – ‘Keep All’). A principal component analysis shows that the novel molecular cutoffs codify chemical information captured by the respective QuBiLS-MIDAS KA-MDs, as well as information not captured by the latter. Lastly, a QSAR study to obtain deeper knowledge of the contribution of the proposed methods was carried out, using four molecular datasets (steroids (STER), angiotensin converting enzyme (ACE), thermolysin inhibitors (THER) and thrombin inhibitors (THR)) widely used as benchmarks in the evaluation of several methodologies. One to four variable QSAR models based on multiple linear regression were developed for each compound dataset following the original division into training and test sets. The results obtained reveal that the novel cutoff procedures yield superior performances relative to those of the QuBiLS-MIDAS KA-MDs in the prediction of the biological activities considered. From the results achieved, it can be suggested that the proposed <i>N</i>-tuple topological/geometric cutoffs constitute a relevant criteria for generating MDs codifying particular atomic relations, ultimately useful in enhancing the modelling capacity of the QuBiLS-MIDAS 3D-MDs.
DOI: 10.7910/dvn/v1rjpf/lvjvxn
title: snk20150125_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/e0wir1
title: snk20160307_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/9xbuqn
title: snk20150721_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/hbmmjk
title: snk20161225_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/jpr8dd
title: snk20160709_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/s70pmh
title: snk20161006_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/xmfxrz
title: snk20160422_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.3988809
title: Supplementary Material for: Low Density Lipoprotein Cholesterol and the Outcome of Acute Ischemic Stroke: Results of a Large Hospital-Based Study

description: Studies show inconsistent associations between low-density lipoprotein cholesterol (LDL-C) and stroke outcome. We assessed these associations among patients with first-ever acute ischemic stroke (AIS) in China. Patients with first-ever AIS were categorized into 3 groups: normal LDL, marginally elevated LDL and high LDL - according to the LDL-C values on admission. The outcome measures that were investigated in each group included mortality, dependence and recurrence of vascular events. Patients with high LDL-C had higher mortality rates than did those with normal LDL-C at both 12 and 36 months, but this difference disappeared after adjustment for covariates. There was no difference between groups in mortality at 3 months and dependency or recurrence at 3, 12 or 36 months. LDL-C level was associated with long-term mortality after stroke, but was not an independent prognostic factor.
DOI: 10.7910/dvn/v1rjpf/mpdslj
title: snk20160423_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/vylgln
title: snk20160913_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.3988809.v2
title: Supplementary Material for: Low Density Lipoprotein Cholesterol and the Outcome of Acute Ischemic Stroke: Results of a Large Hospital-Based Study

description: Studies show inconsistent associations between low-density lipoprotein cholesterol (LDL-C) and stroke outcome. We assessed these associations among patients with first-ever acute ischemic stroke (AIS) in China. Patients with first-ever AIS were categorized into 3 groups: normal LDL, marginally elevated LDL and high LDL - according to the LDL-C values on admission. The outcome measures that were investigated in each group included mortality, dependence and recurrence of vascular events. Patients with high LDL-C had higher mortality rates than did those with normal LDL-C at both 12 and 36 months, but this difference disappeared after adjustment for covariates. There was no difference between groups in mortality at 3 months and dependency or recurrence at 3, 12 or 36 months. LDL-C level was associated with long-term mortality after stroke, but was not an independent prognostic factor.