cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.17639/nott.6854
title: An in vivo systematic genetic analysis of tumour progression in Drosophila - RNAi line: 33412

description: This data set forms part of the larger 'Fly Cancer Screen' data set, which consists of over 700 image sets
description: Metastasis is the leading cause of death for cancer patients. Consequently it is imperative that we improve our understanding of the molecular mechanisms that underlie progression of tumour growth towards malignancy. Advances in genome characterisation technologies have been very successful in identifying commonly mutated or misregulated genes in a variety of human cancers. A major challenge however is the translation of these findings to new biological insight due to the difficulty in evaluating whether these candidate genes drive tumour progression. Using the genetic amenability of Drosophila melanogaster we generated tumours with specific genotypes in the living animal and carried out a detailed systematic loss-of-function analysis to identify numerous conserved genes that enhance or suppress epithelial tumour progression. This enabled the discovery of functional cooperative regulators of invasion and the establishment of a network of conserved ‘invasion suppressors’. RNAi line: 33412 (III) Source: Bloomington Name: sdk Full name: sidekick Also known as: EG:BACR19J1 .1, CT16627 Annotation symbol: CG5227 FlyBase ID: FBgn0021764 File naming convention: File names typically contain representations of date (DDMMYY), RNAi Line, Animal Number and, in some cases, window (to accommodate larger samples that require multiple image stacks)
DOI: 10.17639/nott.7251
title: BRIGhTMIND trial-motivating mechanism of action analysis plan: resting-state fMRI

description: This is the statistical analysis plan for a set of mechanism of action studies for the BRIGhTMIND clinical trial of transcranial magnetic stimulation for major depressive disorder. This statistical analysis plan concerns testing of hypotheses that motivated the trial itself and thus were specified in the NIHR Efficacy and Mechanism Evaluation (EME) funding application. There will be two such analysis plans - the present one concerns analyses of resting-state functional magnetic resonance imaging (fMRI) data. The second, to be published separately, concerns analyses of magnetic resonance spectroscopy (MRS) data. Details about the trial itself can be found in the main trial protocol paper (Morriss et al., 2020, doi: 10.1136/bmjopen-2020-038430). Further details on the imaging analysis steps conducted as part of trial delivery can be found in the published magnetic resonance imaging protocol paper (Pszczolkowski et al., 2022, doi: 10.2196/31925).
DOI: 10.17639/nott.7285
title: Secondary ion mass spectrometry analysis of pentosan polysulfate

description: Pentosan polysulfate sodium (PPS) is a glycosaminoglycan mimetic that is the only current active pharmaceutical ingredient (API) for the oral treatment of interstitial cystitis. PPS is an inherently complex API due to variations in chain length, backbone structure, sulfation pattern and end group making discriminating between batch-to-batch as well as manufacturer-to-manufacturer differences difficult. In this study high throughput liquid handling and time-of-flight secondary ion mass spectrometry (ToF-SIMS) is used to enable the rapid chemical analysis (450 samples in 6 hours) of small amounts (≈150 ng) of PPS. Chemical discrimination between PPS produced by different manufacturers and, in one case, batch-to-batch variation of the same manufacturer is achieved. Analysis of samples using a 3D-OrbiSIMS instrument is used to provide confident assignment of the discriminating ions to enable structural interpretation of the variance observed between samples. Together with analysis of samples spiked with NaOAc or NaSO4, free sulphate and acetate along with sulphate pattern are implicated as key differences between manufacturers/batches. This approach is likely to be highly beneficial for the rapid quality control of PPS.
DOI: 10.17639/nott.7244
title: Analytical derivation and numerical validation of novel scaling laws for air-water flows

description: A MATLAB application to find different configurations of the novel scaling laws for air-water flows. This app allows for the generation of different configurations by setting assumptions for air compressibility. By knowing the laboratory conditions, e.g. the properties of the fluid, the app calculates the conditions under which air-water flows are self-similar, i.e. the behaviour of the scaled laboratory model is invariant with respect to its prototype. The self-similar conditions are calculated by applying the Lie-group transformation to the governing equations of air-water flows, i.e. including the surface tension and the air compressibility effects.
DOI: 10.17639/nott.7259
title: Raw data for non-collinear magnetism in the post-perovskite thiocyanate frameworks CsM(NCS)3

description: Data and notebooks for supporting data for publication
DOI: 10.17639/nott.7258
title: Development of nanoparticle loaded microneedles for drug delivery to a brain tumour resection site

description: Raw data for paper -Muresan, P., P. McCrorie, F. Smith, C. Vasey, V. Taresco, D. J. Scurr, S. Kern, S. Smith, P. Gershkovich, R. Rahman and M. Marlow (2022). "Development of nanoparticle loaded microneedles for drug delivery to a brain tumour resection site." European Journal of Pharmaceutics and Biopharmaceutics. https://doi.org/10.1016/j.ejpb.2022.11.016
DOI: 10.17639/nott.7277
title: Supplementary data for Inertial effects in just-saturated axisymmetric column collapses

description: This data set contains supplementary data for the publication 'Inertial effects in just-saturated axisymmetric column collapses' which has been sent for review to Granular matter. The repository contains the raw video files of the conducted experiments as well as an example of the image thresholding technique used to capture the evolution of both the granular and fluid fronts.
DOI: 10.17639/nott.7253
title: Microparticles decorated with cell-instructive surface chemistries actively promote wound healing
title: Wound healing microparticles

description: Wound healing is a complex biological process involving close crosstalk between various cell types. Dysregulation in any of these processes, such as in diabetic wounds, results in chronic non-healing wounds. Fibroblasts are a critical cell type involved in wound healing. We screened 315 different polymer surfaces to identify candidates which actively drove fibroblasts towards either pro- or anti-proliferative functional phenotypes. Fibroblast-instructive chemistries were identified, which we synthesized into surfactants to fabricate easy to administer microparticles for direct application to diabetic wounds. The pro-proliferative microfluidic derived particles were able to successfully promote neovascularisation, granulation tissue formation and wound closure after a single application to the wound bed. The data within this collection is associated with in vitro and in vivo assays carried out within the manuscript.
DOI: 10.17639/nott.7335
title: The art of belonging

description: I am requesting that would like the record and metadata to be live and searchable, but the data files themselves to be permanently embargoed / restricted (2e) of the UoN data sharing guidance.
description: Recent unprecedented movement of migrants across Europe means that municipal leaders need to support young, often unaccompanied, involuntary migrants to adapt to their new cities. Young migrants find pathways to integration challenging, while settled urban communities experience shifting structural and social relations as new arrivals are accommodated in their neighbourhoods. This project extends existing knowledge of migration by building on established collaborations between stakeholders in Nottingham and Lund. It will analyse how place-making through arts and culture fosters a sense of engagement and supports integration, and through developing arts interventions that can be replicated in other contexts. The multi-actor interdisciplinary applied research project’s goals are to: 1) deepen conceptual understanding of how arts-based place-making activities contribute to enhanced social and relational connections between communities in urban places; 2) facilitate young migrants’ place-attachment and integration through cultural participation, with a focus on gender; 3) co-create a sustainable repertoire of tools for municipalities to use in their strategic plans for supporting migrants; 4) develop a shared knowledge platform for cities across Europe to find sustainable solutions to social integration through arts based activities that enable all citizens, including the newly arrived, to contribute to urban societies.
DOI: 10.17639/nott.7320
title: DigiScore TENOR commissions: Ingrid Laubrock and Kitty Xiao
title: Cullithumpian Ensemble commissions

description: DigiScore project was happy to support 2 commissions through our University of Concordia (Canada) partner Sandeep Bhagwati. These works were Tendons for Transformation by Kitty Xiao and Path/Fields by Ingrid Laubrock. Both of the digital scores shared a degree of openness which included structured improvisation where performers’ agency was welcomed as an interpretive approach
DOI: 10.17639/nott.7321
title: Predictors of outcome in thymectomy patients with acetylcholine receptor antibody-positive generalised myasthenia gravis

description: To identify the variables that predict disease outcome (measured by Myasthenia Gravis Foundation of America Post Intervention Status/MGFA-PIS) in adult patients with ACRA- positive generalized MG that underwent thymectomy and who had been followed-up for at least 2 years following thymectomy.
DOI: 10.17639/nott.7322
title: Experimental data for SiC/YAG composite coatings by a novel liquid fuelled high velocity oxy-fuel suspension thermal spray

description: Publicly available data from the experimental investigation related to the publication entitled "SiC/YAG composite coatings by a novel liquid fuelled high velocity oxy-fuel suspension thermal spray".
DOI: 10.17639/nott.7299
title: DATA for: Measuring "Group Cohesion" to Reveal the Power of Social Relationships in Team Production

description: This dataset contains the data and analysis files of experiments conducted in the CeDEx laboratory at the University of Nottingham and at the BEEL laboratory at the University of Birmingham.
DOI: 10.17639/nott.7221
title: Time resolved growth of (N)-polycyclic aromatic hydrocarbons in engine deposits uncovered with OrbiSIMS depth profiling

description: Carbonaceous deposits are ubiquitous, being formed on surfaces in engines, fuel systems and on catalysts operating at high temperatures for hydrocarbon transformations. In internal combustion engines, their formation negatively affects worldwide vehicle emissions and fuel economy, leading to premature deaths and environmental damage. Deposit composition and formation pathways are poorly understood due to their insolubility and the intrinsic complexity of their layered carbonaceous matrix. Here, we apply the in-situ high resolution analysis capabilities of 3D Orbitrap secondary ion mass spectrometry (3D OrbiSIMS) depth profiling on 16 lab grown deposits and evidence common molecular distributions in deposit depth and in positions relative to the combustion chamber. We observe the products of the growth of both planar and curved polycyclic aromatic hydrocarbons to form small fullerenes over time in the engine and propose possible formation pathways which explain the molecular distributions observed. These include alkyl scission, cyclisation of aliphatic side chains and hydrogen abstraction C2H2 addition to form larger aromatic structures. We apply this pathway to previously unidentified nitrogen containing structures in deposits including quinolines and carbazoles. For the first time, 3D OrbiSIMS results were compared and validated with data from atmospheric pressure matrix assisted laser desorption ionization MS. The comprehensive characterization provided will help the development of a new generation of chemical additives to reduce deposits, and thus improve vehicle emissions and global air quality.
DOI: 10.17639/nott.7290
title: Photoemission electron microscopy images of antiferromagnetic half-skyrmions and analysis of their current-driven motion

description: Antiferromagnetic half-skyrmions are generated and controllably moved using electrical pulses in CuMnAs microdevices. The data collection contains PEEM images identifying half-skyrmions and tracking their displacement with each pulse.
DOI: 10.17639/nott.7255
title: Data from: Loss of nitrogen fixing capacity in a montane lichen is linked to increased nitrogen deposition

description: 1. The circumboreal/circumpolar N2-fixing lichen Stereocaulon vesuvianum is amongst the most widespread and abundant fruticose species in montane Britain but has lost the capacity to fix N2 over large areas of the country. 2. To investigate whether loss of N2-fixation in S. vesuvianum is linked to increased N deposition, we examined thallus morphology, physiology and chemistry at twelve locations representing an N deposition gradient of 3-40 kg ha-1 yr-1. Measurements were made in parallel on a non-N2-fixing reference species (Parmelia saxatilis). Presence or absence of cephalodia (N2-fixing nodules containing the cyanobacterium Stigonema sp) was recorded in over 500 herbarium specimens of S. vesuvianum dating back to 1820. 3. Cephalodium abundance in S. vesuvianum, and 15N concentration in S. vesuvianum and P. saxatilis, were strongly negatively correlated with N deposition and particularly with dry deposited N; cephalodia do not form at total N deposition rates ≥ 8-9 kg ha-1 yr-1. Other morphological oddities in S. vesuvianum at N-polluted sites include increased apothecium (fungal reproductive structure) production and green algal biofilm development. Biofilm covered thalli without cephalodia lacked nitrogenase activity and cephalodia at sites where they rarely develop had nitrogenase activities typical for this species. The presence or absence of cephalodia in herbarium specimens of S. vesuvianum suggest that the present-day N-deposition linked gradient in N2-fixing capacity did not exist in the 19th century and largely developed between 1900-1940. 4. Synthesis. We provide clear evidence that N2-fixing capacity in S. vesuvianum has been lost in regions subjected to many decades of enhanced atmospheric N deposition. This loss is consistent with established models of diazotrophy which identify supply of combined N as an inhibitor of N2-fixation. Progressive depletion of thallus 15N with increasing N deposition is in line with available data suggesting that much atmospheric N pollution is 15N-depleted. Rates of nitrogenase activity in S. vesuvianum are low compared to other symbiotic systems and perhaps more likely supplanted by elevated N deposition. We suggest that other ecosystem compartments with low rates of fixation (e.g. soils) might also be susceptible to N pollution and merit investigation.
DOI: 10.17639/nott.7280
title: Autistic Veterinary Surgeon Mental Wellbeing and Psychosocial Working Conditions

description: In the absence of evidence concerning mental wellbeing in autistic veterinary surgeons, the first aim of this study was to generate a profile of mental wellbeing in this population and draw comparisons with veterinary surgeon and general adult population norms. A high-quality psychosocial work environment may represent a protective factor for mental wellbeing and retention. Thus, the second aim of this study was to explore the extent to which autistic veterinary surgeons’ psychosocial working conditions meet aspirational UK government Management Standards and compare this to general workforce and veterinary surgeon norms. The third aim was to explore the strength and direction of linkages between psychosocial working conditions and mental wellbeing in order to generate recommendations on psychosocial work environment modifications to support mental wellbeing.
DOI: 10.17639/nott.7261
title: DRIVE Project interview data

description: These are the redacted transcriptions of interviews held with disabled refugee students and their families, education officials and NGO workers in South Africa, Uganda and Zimbabwe.
DOI: 10.17639/nott.7273
title: Graphene nanoribbons with hBN passivated edges grown by high-temperature molecular beam epitaxy

description: Integration of graphene and hexagonal boron nitride (hBN) in lateral heterostructures has provided a route to broadly engineer the material properties by quantum confinement of electrons or introduction of novel electronic and magnetic states at the interface. In this work we demonstrate lateral heteroepitaxial growth of graphene nanoribbons (GNRs) passivated by hBN using high-temperature molecular beam epitaxy (HT-MBE) to grow graphene in oriented hBN trenches formed ex-situ by catalytic nanoparticle etching. High resolution atomic force microscopy (AFM) reveals that graphene nanoribbons grow epitaxially from the etched hBN edges, and merge to form a graphene nanoribbon network passivated by hBN. Using conductive AFM we probe the nanoscale electrical properties of the nanoribbons and observe quasiparticle interference patterns caused by intervalley scattering at the graphene/hBN interface, which carries implications for the potential transport characteristics of hBN passivated GNR devices.
DOI: 10.17639/nott.7254
title: Category relevance attenuates overshadowing in human predictive learning

description: In situations in which multiple predictors anticipate the presence or absence of an outcome, cues compete to anticipate the outcome, resulting in a loss of associative strength compared to control conditions without additional cues. Critically, there are multiple factors modulating the magnitude and direction of such competition, although in some scenarios the effect of these factors remains unexplored. We sought to assess whether the relative salience of the elements in a compound of cues modulates the magnitude of the overshadowing effect in human predictive learning. Two separable categories (i.e., colors and symbols) were used in a predictive learning task. In Experiment 1, different groups of participants were granted with different time of exposure to a compound of cues belonging to different categories (color and symbol) to evaluate potential differences in the magnitude of overshadowing. Furthermore, we used post-test questionnaires to assess whether participants used either only one or both categories during training, and assessed if this impacted the magnitude of overshadowing. In general, overshadowing was not modulated by the time of exposition, except in the case of very short time of exposition with prominent learning about the most salient category. In Experiment 2, the relative salience of a category was biased via prior experience either with a biconditional discrimination or attending only the relevant category (either color or symbol). Previously relevant categories were less prone to overshadowing, but not in the alternative one. Results are discussed in light of attentional and configural theories of associative learning.
DOI: 10.17639/nott.7301
title: Data for "Rejection-free quantum Monte Carlo in continuous time from transition path sampling"

description: Contains the data used in all figures throughout the publication "Rejection-free quantum Monte Carlo in continuous time from transition path sampling" by Luke Causer, Konstantinos Sfairopoulos, Jamie F. Mair, and Juan P. Garrahan.
DOI: 10.17639/nott.7279
title: Mass-spectral data generated by metabolomics analysis of samples from dairy cattle

description: Samples were collected from dairy cows to investigate how the metabolic fingerprint alters with lameness. Samples were analysed using LC-MS
DOI: 10.17639/nott.7302
title: Patch Area and Uniform Sampling on the Surface of Any Ellipsoid

description: Source code (C++), run script (shell), and analysis scripts (Python) in relation to the article "Patch Area and Uniform Sampling on the Surface of Any Ellipsoid"
DOI: 10.17639/nott.7268
title: Cocoa flavanol supplementation and the effect on insulin resistance in females who are overweight or obese; a randomized, placebo-controlled trial

description: There is interest in the impact that dietary interventions can have on preventing the transition from insulin resistance to type 2 diabetes, including a suggestion that bioactive components of cocoa may enhance fasting insulin sensitivity. However, a role for Cocoa Flavanols in reducing insulin resistance in the insulin-stimulated state, an important risk factor for cardiovascular disease, is unresolved. This study investigated whether cocoa flavanol consumption improved whole-body insulin-mediated glucose uptake in females with overweight/obesity, using a randomized, double-blinded, placebo-controlled, parallel-group design.
DOI: 10.17639/nott.7272
title: The RECORDER (Registration of Complex Rare Diseases – Exemplars in Rheumatology) project

description: The RECORDER (Registration of Complex Rare Diseases – Exemplars in Rheumatology) project, in collaboration with the National Congenital Anomaly and Rare Disease Registration Service (NCARDRS), has established the methodologies for identification and registration of people with rare autoimmune diseases within Hospital Episodes Statistics (HES) data. NCARDRS is part of the National Rare Disease Registration Service (NDRS) at NHS Digital (NHSD). They have access to linked national datasets of electronic health records at patient-identifiable level for the whole population of England. The legal basis to access this data is covered by NCARDRS’ Section 254 approval (sections 254(1) and 254(6) of the 2012 Health and Social Care Act). This contains specific legal instruction to collect patient data without informed consent. Due to legal and ethical considerations, supporting data from RECORDER publications cannot be made openly available. However, NCARDRS data are available to all who have a legal basis to access them. Further details about the data and conditions for access are available by application to the National Disease Registration Service. NDRS website: https://digital.nhs.uk/ndrs How NDRS collects and records data: https://digital.nhs.uk/ndrs/data/collecting-and-keeping-patient-data-safe Accessing NDRS data: https://digital.nhs.uk/ndrs/data/access-to-data
DOI: 10.17639/nott.7304
title: Engineering nanowires in bacteria to elucidate electron transport structural–functional relationships

description: Data set associated with the following manuscript: "Engineering nanowires in bacteria to elucidate electron transport structural–functional relationships" Accepted for publication in Scientific Reports
DOI: 10.17639/nott.7266
title: Mobile robotic telepresence long-term user interviews
title: Interview exploration into what is it like to be telepresent through a robot

description: Transcripts of interviews with people who have had experience with using Mobile Robotic Telepresence of extended periods of time
DOI: 10.17639/nott.7308
title: Nine months of daily LiDAR and MetOcean data along the eroding soft cliff coast of Happisburgh, Norfolk, UK

description: The repository contains the codes for retrieving the total precipitation and sea states parameters at Happisburgh for the observation time described in the paper Nine months of daily LiDAR and MetOcean data along the eroding soft cliff coast of Happisburgh, Norfolk, UK (Pennington et al. 2023). The codes are written in Python and require the use of the CDS API, which can be obtained by ECMWF (https://github.com/ecmwf/cdsapi)