cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.8162609.v1
title: Moderate-intensity exercise allows enhanced protection against oxidative stress-induced cardiac dysfunction in spontaneously hypertensive rats

description: The progression of myocardial injury secondary to hypertension is a complex process related to a series of physiological and molecular factors including oxidative stress. This study aimed to investigate whether moderate-intensity exercise (MIE) could improve cardiac function and oxidative stress in spontaneously hypertensive rats (SHRs). Eight-week-old male SHRs and age-matched male Wistar-Kyoto rats were randomly assigned to exercise training (treadmill running at a speed of 20 m/min for 1 h continuously) or kept sedentary for 16 weeks. Cardiac function was monitored by polygraph; cardiac mitochondrial structure was observed by scanning electron microscope; tissue free radical production was measured using dihydroethidium staining. Expression levels of SIRT3 and SOD2 protein were measured by western blot, and cardiac antioxidants were assessed by assay kits. MIE improved the cardiac function of SHRs by decreasing left ventricular systolic pressure (LVSP), and first derivation of LVP (+LVdP/dtmax and −LVdP/dtmax). In addition, exercise-induced beneficial effects in SHRs were mediated by decreasing damage to myocardial mitochondrial morphology, decreasing production of reactive oxygen species, increasing glutathione level, decreasing oxidized glutathione level, increasing expression of SIRT3/SOD2, and increasing activity of superoxide dismutase. Exercise training in SHRs improved cardiac function by inhibiting hypertension-induced myocardial mitochondrial damage and attenuating oxidative stresses, offering new insights into prevention and treatment of hypertension.
DOI: 10.6084/m9.figshare.14978335
title: Additional file 1 of A novel risk score system for prognostic evaluation in adenocarcinoma of the oesophagogastric junction: a large population study from the SEER database and our center

description: Additional file 1 Supplementary Table 1. Transcoding of each clinical feature in this study.
DOI: 10.6084/m9.figshare.14978335.v1
title: Additional file 1 of A novel risk score system for prognostic evaluation in adenocarcinoma of the oesophagogastric junction: a large population study from the SEER database and our center

description: Additional file 1 Supplementary Table 1. Transcoding of each clinical feature in this study.
DOI: 10.6084/m9.figshare.8162615
title: Linderae radix ethanol extract attenuates alcoholic liver injury via attenuating inflammation and regulating gut microbiota in rats

description: This study aimed to explore the influence of gut microbiota alterations induced by Linderae radix ethanol extract (LREE) on alcoholic liver disease (ALD) in rats and to study the anti-inflammatory effect of LREE on ALD through the lipopolysaccharide (LPS) toll-like receptor 4 (TLR4)-nuclear factor kappa B (NF-κB) pathway. ALD rat models were established by intragastric liquor [50% (v/v) ethanol] administration at 10 mL/kg body weight for 20 days. Rats were divided into six groups: normal group (no treatment), model group (ALD rats), Essentiale group (ALD rats fed with Essentiale, 137 mg/kg), and LREE high/moderate/low dose groups (ALD rats fed with 4, 2, or 1 g LREE/kg). NF-κB and LPS levels were evaluated. Liver pathological changes and intestinal ultrastructure were examined by hematoxylin and eosin staining and transmission electron microscopy. The gut microbiota composition was evaluated by 16S rDNA sequencing. Expression levels of TLR4 and CD68 in liver tissue, and occludin and claudin-1 in intestinal tissue were measured. LREE treatment significantly reduced NF-κB and LPS levels, improved liver pathological changes, and ameliorated intestinal ultrastructure injury. Meanwhile, LREE-fed groups showed a higher abundance of Firmicutes and a lower abundance of Bacteroidetes than the rats in the model group. Administration of LREE suppressed TLR4 overexpression and promoted the expression of occludin and claudin-1 in intestine tissue. Thus, LREE could partly ameliorate microflora dysbiosis, suppress the inflammatory response, and attenuate liver injury in ALD rats. The protective effect of LREE might be related to the LPS-TLR4-NF-κB pathway.
DOI: 10.6084/m9.figshare.8162615.v1
title: Linderae radix ethanol extract attenuates alcoholic liver injury via attenuating inflammation and regulating gut microbiota in rats

description: This study aimed to explore the influence of gut microbiota alterations induced by Linderae radix ethanol extract (LREE) on alcoholic liver disease (ALD) in rats and to study the anti-inflammatory effect of LREE on ALD through the lipopolysaccharide (LPS) toll-like receptor 4 (TLR4)-nuclear factor kappa B (NF-κB) pathway. ALD rat models were established by intragastric liquor [50% (v/v) ethanol] administration at 10 mL/kg body weight for 20 days. Rats were divided into six groups: normal group (no treatment), model group (ALD rats), Essentiale group (ALD rats fed with Essentiale, 137 mg/kg), and LREE high/moderate/low dose groups (ALD rats fed with 4, 2, or 1 g LREE/kg). NF-κB and LPS levels were evaluated. Liver pathological changes and intestinal ultrastructure were examined by hematoxylin and eosin staining and transmission electron microscopy. The gut microbiota composition was evaluated by 16S rDNA sequencing. Expression levels of TLR4 and CD68 in liver tissue, and occludin and claudin-1 in intestinal tissue were measured. LREE treatment significantly reduced NF-κB and LPS levels, improved liver pathological changes, and ameliorated intestinal ultrastructure injury. Meanwhile, LREE-fed groups showed a higher abundance of Firmicutes and a lower abundance of Bacteroidetes than the rats in the model group. Administration of LREE suppressed TLR4 overexpression and promoted the expression of occludin and claudin-1 in intestine tissue. Thus, LREE could partly ameliorate microflora dysbiosis, suppress the inflammatory response, and attenuate liver injury in ALD rats. The protective effect of LREE might be related to the LPS-TLR4-NF-κB pathway.
DOI: 10.6084/m9.figshare.11308355
title: MOESM2 of A probabilistic method for leveraging functional annotations to enhance estimation of the temporal order of pathway mutations during carcinogenesis

description: Additional file 2 Table S1 provides a list of “core” pathway genes in each of the 9 key cancer pathways considered in the paper.
DOI: 10.6084/m9.figshare.11308355.v1
title: MOESM2 of A probabilistic method for leveraging functional annotations to enhance estimation of the temporal order of pathway mutations during carcinogenesis

description: Additional file 2 Table S1 provides a list of “core” pathway genes in each of the 9 key cancer pathways considered in the paper.
DOI: 10.6084/m9.figshare.14978395
title: Additional file 11 of tRNA derived fragment (tRF)-3009 participates in modulation of IFN-α-induced CD4+ T cell oxidative phosphorylation in lupus patients

description: Additional file 11: Table S6. Predicted target 3′UTR regions of tRF-3009.
DOI: 10.6084/m9.figshare.14978395.v1
title: Additional file 11 of tRNA derived fragment (tRF)-3009 participates in modulation of IFN-α-induced CD4+ T cell oxidative phosphorylation in lupus patients

description: Additional file 11: Table S6. Predicted target 3′UTR regions of tRF-3009.
DOI: 10.6084/m9.figshare.14978398
title: Additional file 12 of tRNA derived fragment (tRF)-3009 participates in modulation of IFN-α-induced CD4+ T cell oxidative phosphorylation in lupus patients

description: Additional file 12: Table S7. Predicted target promoter regions of tRF-3009.
DOI: 10.6084/m9.figshare.14978398.v1
title: Additional file 12 of tRNA derived fragment (tRF)-3009 participates in modulation of IFN-α-induced CD4+ T cell oxidative phosphorylation in lupus patients

description: Additional file 12: Table S7. Predicted target promoter regions of tRF-3009.
DOI: 10.6084/m9.figshare.14978392
title: Additional file 10 of tRNA derived fragment (tRF)-3009 participates in modulation of IFN-α-induced CD4+ T cell oxidative phosphorylation in lupus patients

description: Additional file 10: Table S5. The KEGG analysis of differentially expressed genes in the ‘systemic lupus erythematosus pathway’.
DOI: 10.6084/m9.figshare.14978392.v1
title: Additional file 10 of tRNA derived fragment (tRF)-3009 participates in modulation of IFN-α-induced CD4+ T cell oxidative phosphorylation in lupus patients

description: Additional file 10: Table S5. The KEGG analysis of differentially expressed genes in the ‘systemic lupus erythematosus pathway’.
DOI: 10.5281/zenodo.10213647
title: GOSAT V9 Fusion Dataset

description: This dataset contains the calibrated GOSAT XCO2 retrievals against the OCO-2 XCO2 benchmark based on the machine learning models, which is a harmonized dataset that aligns more congruently with OCO-2 XCO2 retrievals. Such integration is pivotal for enhancing observational constraints in carbon flux inversions. The source of Level 2 products for both satellites is NASA's Goddard Earth Science Data and Information Services Center (GES-DISC), accessible at https://disc.gsfc.nasa.gov/. The dataset is shared in the format of the ACOS_L2_Lite_FP product (GOSAT Level 2 XCO2 product) with retrievals of poor quality having been filtered out. The latest version of the dataset features modifications in the model adjustment process and also includes recalibrated uncertainties for each observation resulting from model corrections.
DOI: 10.5281/zenodo.8321873
title: GOSAT V9 Fusion Dataset

description: This dataset contains the calibrated GOSAT XCO2 retrievals against the OCO-2 XCO2 benchmark based on the machine learning models, which is a harmonized dataset that aligns more congruently with OCO-2 XCO2 retrievals. Such integration is pivotal for enhancing observational constraints in carbon flux inversions. The source of Level 2 products for both satellites is NASA's Goddard Earth Science Data and Information Services Center (GES-DISC), accessible at https://disc.gsfc.nasa.gov/. The dataset is shared in the format of the ACOS_L2_Lite_FP product (GOSAT Level 2 XCO2 product) with retrievals of poor quality having been filtered out.
DOI: 10.5281/zenodo.10649231
title: GOSAT V9 Fusion Dataset

description: This dataset contains the calibrated GOSAT XCO2 retrievals against the OCO-2 XCO2 benchmark based on the machine learning models, which is a harmonized dataset that aligns more congruently with OCO-2 XCO2 retrievals. Such integration is pivotal for enhancing observational constraints in carbon flux inversions. The source of Level 2 products for both satellites is NASA's Goddard Earth Science Data and Information Services Center (GES-DISC), accessible at https://disc.gsfc.nasa.gov/. The dataset is shared in the format of the ACOS_L2_Lite_FP product (GOSAT Level 2 XCO2 product) with retrievals of poor quality having been filtered out. The latest version of the dataset features modifications in the model adjustment process and also includes recalibrated uncertainties for each observation resulting from model corrections. The data time range is from April 2009 to June 2020, and the folders are divided by year.
DOI: 10.5281/zenodo.8321872
title: GOSAT V9 Fusion Dataset

description: This dataset contains the calibrated GOSAT XCO2 retrievals against the OCO-2 XCO2 benchmark based on the machine learning models, which is a harmonized dataset that aligns more congruently with OCO-2 XCO2 retrievals. Such integration is pivotal for enhancing observational constraints in carbon flux inversions. The source of Level 2 products for both satellites is NASA's Goddard Earth Science Data and Information Services Center (GES-DISC), accessible at https://disc.gsfc.nasa.gov/. The dataset is shared in the format of the ACOS_L2_Lite_FP product (GOSAT Level 2 XCO2 product) with retrievals of poor quality having been filtered out. The latest version of the dataset features modifications in the model adjustment process and also includes recalibrated uncertainties for each observation resulting from model corrections. The data time range is from April 2009 to June 2020, and the folders are divided by year.
DOI: 10.6084/m9.figshare.14978416
title: Additional file 6 of tRNA derived fragment (tRF)-3009 participates in modulation of IFN-α-induced CD4+ T cell oxidative phosphorylation in lupus patients

description: Additional file 6: Table S1. Clinical charateristics of SLE patients, disease controls and healthy controls.
DOI: 10.6084/m9.figshare.14978416.v1
title: Additional file 6 of tRNA derived fragment (tRF)-3009 participates in modulation of IFN-α-induced CD4+ T cell oxidative phosphorylation in lupus patients

description: Additional file 6: Table S1. Clinical charateristics of SLE patients, disease controls and healthy controls.
DOI: 10.6084/m9.figshare.16551265
title: Additional file 1 of Circular RNA circRNF13 inhibits proliferation and metastasis of nasopharyngeal carcinoma via SUMO2

description: Additional file 1: Suppemental Table 1. Probes for fluorescence in situ hybridization and RNA pulldown, siRNAs, primers for RT-PCR and vectors. Suppemental Table 2. List of antibodies for immunohistochemistry, western blotting, immunofluorescence, and RNA pulldown experiments. Suppemental Table 3. The top 20 circRNAs identified in NPC 5-8F cells using the next-generation sequencing of mRNA (RNA-seq). Suppemental Table 4. Clinicopathological data of 36 NPC and 12 NPE tissues measured by RT-PCR. Suppemental Table 5. Proteomic analysis of the circRNF13-regulated proteins in CNE2 cells transfected with sicircRNF13 or scrambled siRNA identified by the LC-MS/ MS spectrometry. Suppemental Table 6. The top 20 of the circRNF13-regulated differential proteins in CNE2 cells after knockdown of circRNF13 identified by the LC-MS/MS spectrometry.
DOI: 10.6084/m9.figshare.16551265.v1
title: Additional file 1 of Circular RNA circRNF13 inhibits proliferation and metastasis of nasopharyngeal carcinoma via SUMO2

description: Additional file 1: Suppemental Table 1. Probes for fluorescence in situ hybridization and RNA pulldown, siRNAs, primers for RT-PCR and vectors. Suppemental Table 2. List of antibodies for immunohistochemistry, western blotting, immunofluorescence, and RNA pulldown experiments. Suppemental Table 3. The top 20 circRNAs identified in NPC 5-8F cells using the next-generation sequencing of mRNA (RNA-seq). Suppemental Table 4. Clinicopathological data of 36 NPC and 12 NPE tissues measured by RT-PCR. Suppemental Table 5. Proteomic analysis of the circRNF13-regulated proteins in CNE2 cells transfected with sicircRNF13 or scrambled siRNA identified by the LC-MS/ MS spectrometry. Suppemental Table 6. The top 20 of the circRNF13-regulated differential proteins in CNE2 cells after knockdown of circRNF13 identified by the LC-MS/MS spectrometry.
DOI: 10.6084/m9.figshare.14978422
title: Additional file 7 of tRNA derived fragment (tRF)-3009 participates in modulation of IFN-α-induced CD4+ T cell oxidative phosphorylation in lupus patients

description: Additional file 7: Table S2. Primers used for qRT-PCR.
DOI: 10.6084/m9.figshare.14978422.v1
title: Additional file 7 of tRNA derived fragment (tRF)-3009 participates in modulation of IFN-α-induced CD4+ T cell oxidative phosphorylation in lupus patients

description: Additional file 7: Table S2. Primers used for qRT-PCR.
DOI: 10.6084/m9.figshare.14978425
title: Additional file 8 of tRNA derived fragment (tRF)-3009 participates in modulation of IFN-α-induced CD4+ T cell oxidative phosphorylation in lupus patients

description: Additional file 8: Table S3. Differentially expressed tRFs in CD4+ T cells of SLE patients and healthy controls (Has).
DOI: 10.6084/m9.figshare.14978425.v1
title: Additional file 8 of tRNA derived fragment (tRF)-3009 participates in modulation of IFN-α-induced CD4+ T cell oxidative phosphorylation in lupus patients

description: Additional file 8: Table S3. Differentially expressed tRFs in CD4+ T cells of SLE patients and healthy controls (Has).
DOI: 10.6084/m9.figshare.14978428
title: Additional file 9 of tRNA derived fragment (tRF)-3009 participates in modulation of IFN-α-induced CD4+ T cell oxidative phosphorylation in lupus patients

description: Additional file 9: Table S4. Differentially expressed genes between transfection of tRF-3009 and NC groups.
DOI: 10.6084/m9.figshare.14978428.v1
title: Additional file 9 of tRNA derived fragment (tRF)-3009 participates in modulation of IFN-α-induced CD4+ T cell oxidative phosphorylation in lupus patients

description: Additional file 9: Table S4. Differentially expressed genes between transfection of tRF-3009 and NC groups.
DOI: 10.6084/m9.figshare.11308448
title: MOESM1 of The m6A eraser FTO facilitates proliferation and migration of human cervical cancer cells

description: Additional file 1: Table S1. Differentially expressed genes in Hela cells with FTO knockdown.
DOI: 10.6084/m9.figshare.11308448.v1
title: MOESM1 of The m6A eraser FTO facilitates proliferation and migration of human cervical cancer cells

description: Additional file 1: Table S1. Differentially expressed genes in Hela cells with FTO knockdown.
DOI: 10.6084/m9.figshare.11308469
title: MOESM10 of Comparative gene expression profiling of muscle reveals potential candidate genes affecting drip loss in pork

description: Additional file 10: Table S10. Significantly enriched pathways of the critical DE genes detected between low and high drip loss groups.
DOI: 10.6084/m9.figshare.11308469.v1
title: MOESM10 of Comparative gene expression profiling of muscle reveals potential candidate genes affecting drip loss in pork

description: Additional file 10: Table S10. Significantly enriched pathways of the critical DE genes detected between low and high drip loss groups.
DOI: 10.6084/m9.figshare.8162747
title: Effectiveness of electric toothbrush as vibration method on orthodontic tooth movement: a split-mouth study

description: Abstract Objective: To investigate the effects of application of vibratory stimuli, using an electric toothbrush, on the rate of orthodontic tooth movement during maxillary canine retraction. Methods: A split-mouth study was conducted in 28 subjects (mean age = 20.8 years; ranging from 18 to 24 years) whose bilateral maxillary first premolars were extracted with subsequent canine retraction. On the Vibration side, light force (100 g) was applied to the canine for 90 days, in combination with vibratory stimuli provided by an electric toothbrush; only orthodontic force was applied to the canine on the non-vibration side. Amount of canine movement was measured monthly. Related to electronic toothbrush usage, a diary was provided to each patient for recording discomfort during experimental period, having 100-mm visual analogue scale (VAS). The paired t-test was used to assess the differences in amount of tooth movement between canines of the vibration and non-vibration sides. Results: The amount of tooth movement was similar for canines on the vibration side and on the non-vibration side (mean 0.81 ± 0.10 mm and 0.82 ± 0.11 mm, respectively, p&gt; 0.05). Plaque accumulation was minimal in any subject throughout the study. No subject reported discomfort as a result of using the electric toothbrush. Conclusions: This study demonstrates that application of vibratory stimuli using an electric toothbrush, in combination with light orthodontic force, do not accelerate orthodontic tooth movement.
DOI: 10.6084/m9.figshare.8162747.v1
title: Effectiveness of electric toothbrush as vibration method on orthodontic tooth movement: a split-mouth study

description: Abstract Objective: To investigate the effects of application of vibratory stimuli, using an electric toothbrush, on the rate of orthodontic tooth movement during maxillary canine retraction. Methods: A split-mouth study was conducted in 28 subjects (mean age = 20.8 years; ranging from 18 to 24 years) whose bilateral maxillary first premolars were extracted with subsequent canine retraction. On the Vibration side, light force (100 g) was applied to the canine for 90 days, in combination with vibratory stimuli provided by an electric toothbrush; only orthodontic force was applied to the canine on the non-vibration side. Amount of canine movement was measured monthly. Related to electronic toothbrush usage, a diary was provided to each patient for recording discomfort during experimental period, having 100-mm visual analogue scale (VAS). The paired t-test was used to assess the differences in amount of tooth movement between canines of the vibration and non-vibration sides. Results: The amount of tooth movement was similar for canines on the vibration side and on the non-vibration side (mean 0.81 ± 0.10 mm and 0.82 ± 0.11 mm, respectively, p&gt; 0.05). Plaque accumulation was minimal in any subject throughout the study. No subject reported discomfort as a result of using the electric toothbrush. Conclusions: This study demonstrates that application of vibratory stimuli using an electric toothbrush, in combination with light orthodontic force, do not accelerate orthodontic tooth movement.
DOI: 10.6084/m9.figshare.14978468
title: Additional file 5 of Transcriptome analysis uncovers the key pathways and candidate genes related to the treatment of Echinococcus granulosus protoscoleces with the repurposed drug pyronaridine

description: Additional file 5:Table S2 All genes with RPKM values and FDRs
DOI: 10.6084/m9.figshare.11308478
title: MOESM1 of Comparative gene expression profiling of muscle reveals potential candidate genes affecting drip loss in pork

description: Additional file 1: Table S1. Phenotypic information of carcass and meat quality traits for the low and high samples selected for transcriptome analysis.
DOI: 10.6084/m9.figshare.14978468.v1
title: Additional file 5 of Transcriptome analysis uncovers the key pathways and candidate genes related to the treatment of Echinococcus granulosus protoscoleces with the repurposed drug pyronaridine

description: Additional file 5:Table S2 All genes with RPKM values and FDRs
DOI: 10.6084/m9.figshare.14978471
title: Additional file 6 of Transcriptome analysis uncovers the key pathways and candidate genes related to the treatment of Echinococcus granulosus protoscoleces with the repurposed drug pyronaridine

description: Additional file 6: Table S3 Enriched GO terms of DEGs
DOI: 10.6084/m9.figshare.14978471.v1
title: Additional file 6 of Transcriptome analysis uncovers the key pathways and candidate genes related to the treatment of Echinococcus granulosus protoscoleces with the repurposed drug pyronaridine

description: Additional file 6: Table S3 Enriched GO terms of DEGs
DOI: 10.6084/m9.figshare.14978474
title: Additional file 7 of Transcriptome analysis uncovers the key pathways and candidate genes related to the treatment of Echinococcus granulosus protoscoleces with the repurposed drug pyronaridine

description: Additional file 7:Table S4 Enriched KEGG pathways of DEGs
DOI: 10.6084/m9.figshare.14978474.v1
title: Additional file 7 of Transcriptome analysis uncovers the key pathways and candidate genes related to the treatment of Echinococcus granulosus protoscoleces with the repurposed drug pyronaridine

description: Additional file 7:Table S4 Enriched KEGG pathways of DEGs
DOI: 10.4121/5e40ecd6-98c4-423c-bd1c-d24f0f7a7a59.v6
title: 20211109 20211215 Main deployment - Nearshore - RealDune/REFLEX

description: Nearshore field measurements of the main November - December deployment of the RealDune/REFLEX experiments at the Dutch coast in Autumn/Winter 2021/2022. The lidar and GoPro data are stored separately. This dataset is part of the data collection 'Nearshore coastal measurements of calm, moderate, and storm conditions at two artificial dunes along the Dutch Coast during the RealDune/REFLEX experiments'.
DOI: 10.6084/m9.figshare.11308478.v1
title: MOESM1 of Comparative gene expression profiling of muscle reveals potential candidate genes affecting drip loss in pork

description: Additional file 1: Table S1. Phenotypic information of carcass and meat quality traits for the low and high samples selected for transcriptome analysis.