cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.14376521.v2
title: Polygenic risk for traumatic loss-related PTSD in US military veterans: Protective effect of secure attachment style

description: To examine whether attachment style moderates the relationship between polygenic risk scores (PRS) for posttraumatic stress disorder (PTSD) re-experiencing (PTSD<sub>REX</sub>) symptoms and the severity of and positive screen for traumatic loss-related PTSD. Data were analysed from 631 US veterans who endorsed ‘unexpected death of a loved one’ as their ‘worst’ traumatic event. Multivariable models evaluated the association between PRS for PTSD<sub>REX,</sub> attachment style, and their interaction in predicting severity and positive screen for PTSD. A gene enrichment analysis was conducted to identify possible molecular mechanisms underlying the association between PTSD<sub>REX</sub> PRS and PTSD. PTSD<sub>REX</sub> PRS (<i>β</i> = 0.17; odds ratio [OR] = 1.85), attachment style (<i>β</i>= −0.33; OR = 0.14), and PTSD<sub>REX</sub> PRS × attachment style interaction (<i>β</i>= −0.12; OR = 0.53) were significant predictors of the severity and positive screen for PTSD. The most significant gene set detected was the gene ontology (GO) cellular component podosome set (GO:0002102, <i>p</i> −5). Having a secure attachment style may help mitigate polygenic risk for developing traumatic loss-related PTSD in US veterans. Podosomes, which are implicated in inflammatory and neuroplasticity processes, may contribute to the genetic liability to developing loss-related PTSD. Psychological treatments targeting attachment security may help mitigate increased polygenic risk for loss-related PTSD in this population.
DOI: 10.6084/m9.figshare.14376479.v1
title: Sleep-related traits and attention-deficit/hyperactivity disorder comorbidity: shared genetic risk factors, molecular mechanisms, and causal effects

description: To evaluate the shared genetic components, common pathways and causal relationship between ADHD and sleep-related phenotypes We used the largest genome-wide association summary statistics available for attention-deficit/hyperactivity disorder (ADHD) and various sleep-related phenotypes (insomnia, napping, daytime dozing, snoring, ease getting up, daytime sleepiness, sleep duration and chronotype). We estimated the genomic correlation using cross-trait linkage disequilibrium score regression (LDSR) and investigated the potential common mechanisms using gene-based cross-trait metanalyses and functional enrichment analyses. The causal effect was estimated using two-sample Mendelian randomization (TSMR), using the inverse variance weighted method as the main estimator. A positive genomic correlation between insomnia, daytime napping, daytime dozing, snoring, daytime sleepiness, short and long sleep duration, and ADHD was observed. Insomnia, daytime sleepiness, and snoring shared genes with ADHD, that are involved in neurobiological functions and regulatory signaling pathways. The TSMR supported a causal effect of insomnia, daytime napping, and short sleep duration on ADHD, and of ADHD on long sleep duration and chronotype. Comorbidity between sleep phenotypes and ADHD may be mediated by common genetic factors that play an important role in neuronal signaling pathways. A causal effect of sleep disturbances and short sleep duration on ADHD reinforced their role as predictors of ADHD.
DOI: 10.6084/m9.figshare.14376479
title: Sleep-related traits and attention-deficit/hyperactivity disorder comorbidity: Shared genetic risk factors, molecular mechanisms, and causal effects

description: To evaluate the shared genetic components, common pathways and causal relationship between ADHD and sleep-related phenotypes We used the largest genome-wide association summary statistics available for attention-deficit/hyperactivity disorder (ADHD) and various sleep-related phenotypes (insomnia, napping, daytime dozing, snoring, ease getting up, daytime sleepiness, sleep duration and chronotype). We estimated the genomic correlation using cross-trait linkage disequilibrium score regression (LDSR) and investigated the potential common mechanisms using gene-based cross-trait metanalyses and functional enrichment analyses. The causal effect was estimated using two-sample Mendelian randomisation (TSMR), using the inverse variance weighted method as the main estimator. A positive genomic correlation between insomnia, daytime napping, daytime dozing, snoring, daytime sleepiness, short and long sleep duration, and ADHD was observed. Insomnia, daytime sleepiness, and snoring shared genes with ADHD, that are involved in neurobiological functions and regulatory signalling pathways. The TSMR supported a causal effect of insomnia, daytime napping, and short sleep duration on ADHD, and of ADHD on long sleep duration and chronotype. Comorbidity between sleep phenotypes and ADHD may be mediated by common genetic factors that play an important role in neuronal signalling pathways. A causal effect of sleep disturbances and short sleep duration on ADHD reinforced their role as predictors of ADHD.
DOI: 10.6084/m9.figshare.14376521.v1
title: Polygenic Risk for Traumatic Loss-related PTSD in U.S. Military Veterans: Protective Effect of Secure Attachment Style

description: To examine whether attachment style moderates the relationship between polygenic risk scores (PRS) for posttraumatic stress disorder (PTSD) re-experiencing (PTSD<sub>REX</sub>) symptoms and the severity of and positive screen for traumatic loss-related PTSD. Data were analyzed from 631 U.S. veterans who endorsed “unexpected death of a loved one” as their ‘worst’ traumatic event. Multivariable models evaluated the association between PRS for PTSD<sub>REX,</sub> attachment style, and their interaction in predicting severity and positive screen for PTSD. A gene enrichment analysis was conducted to identify possible molecular mechanisms underlying the association between PTSD<sub>REX</sub> PRS and PTSD. PTSD<sub>REX</sub> PRS (β = 0.17; odds ratio [OR] = 1.85), attachment style (β= -0.33; OR =0.14), and PTSD<sub>REX</sub> PRS x attachment style interaction (β= -0.12; OR =0.53) were significant predictors of the severity and positive screen for PTSD. The most significant gene set detected was the gene ontology (GO) cellular component podosome set (GO:0002102, p -5). Having a secure attachment style may help mitigate polygenic risk for developing traumatic loss-related PTSD in U.S. veterans. Podosomes, which are implicated in inflammatory and neuroplasticity processes, may contribute to the genetic liability to developing loss-related PTSD. Psychological treatments targeting attachment security may help mitigate increased polygenic risk for loss-related PTSD in this population.
DOI: 10.15151/esrf-es-584752168
title: Foldase or chaperone role of ciclophyllin A in the interaction with TDP-43

description: TDP-43 is a protein that regulates many aspects of RNA processing. In an abnormal phosphorylated state TDP-43 has been linked to the onset of amyotrophic lateral sclerosis. Cyclophilin A (PPIA) is involved in several cellular processes: it is an enzyme accelerating protein folding and also it is a molecular chaperone protecting against oxidative stress and protein misfolding. PPIA is an interacting partner of TDP-43: lack of this interaction induces TDP-43 mislocalization and aggregation, leading to neurodegeneration.We want to elucidate whether PPIA acts as a chaperone, sequestrating TDP-43 in a one to one complex, or it acts as a foldase, realising the TDP-43 substrate after the folding rearrangement. To address this issue we synthetized three different TDP-43 peptides, belonging to the region that regulates aggregation and inter-protein bonds. We plan to observe the interaction of the peptides with PPIA and how their interplay modifies the kinetics of peptides aggregation.
DOI: 10.5281/zenodo.5751777
title: Index for use with the genotyper KAGE

description: Index for use with the genotyper KAGE. This index is for all variants &gt; 0.1% allele frequency from the 1000 Genomes Project and is generated by this pipeline: https://github.com/ivargr/genotyping-benchmarking, commit id 9e25292d96e168b46f4b2c72b407fce607bb1a1b.
DOI: 10.15161/oar.it/74297
title: CovidStat project data

description: This record contains the daily updated data of the CovidStat project. CovidStat is a project carried out by the CovidStat Working Group at INFN, whose creation was promoted within the Italian National Institute of Nuclear Physics with the aim of making a statistical analysis of the data provided daily by the Civil Protection on the spread of the pandemic in Italy. CovidStat data can interactively be browsed at https://covid19.infn.it.
description: The software to process this Root TTree is in the related identifier. Be sure to use the right corresponding version, based on the data in which Root TTree was generated.
DOI: 10.5281/zenodo.5751794
title: CCG Starter Data Kit: Algeria

description: A starter data kit for Algeria
DOI: 10.5281/zenodo.4728143
title: CCG Starter Data Kit: Algeria

description: A starter data kit for Algeria
DOI: 10.25721/d13p-rs03
title: Jeannette ound onoren garden
DOI: 10.6084/m9.figshare.17121434
title: Supplementary Material for: Statin Use and Incidence of Chronic Kidney Disease in Hypercholesterolemia Patients with Normal Renal Function

description: <b><i>Introduction:</i></b> Dyslipidemia is a known risk factor for chronic kidney disease (CKD). The effects of statins on CKD have already been studied in patients with CKD; however, data on the general population are limited. This study aimed to determine the relationship between statin use and the incidence of CKD in patients with hypercholesterolemia having normal renal function. <b><i>Methods:</i></b> A total of 7,856 participants aged 40–79 years at baseline (2009–2010) were included in the final analyses. The participants were divided into statin users (<i>n</i> = 4,168) and statin nonusers (<i>n</i> = 3,668), according to the statin usage. The Cox proportional hazard regression model was used to evaluate the adjusted hazard ratios (HRs) with 95% confidence intervals (CIs) for CKD. <b><i>Results:</i></b> The median follow-up duration was 5.8 years. A total of 543 cases of CKD (285 cases in males and 258 cases in females) occurred during the study period. The estimated cumulative incidence of CKD was significantly different between male statin nonusers and users (<i>p</i> &lt; 0.001), while it was not statistically significant between female statin nonusers and users (<i>p</i> = 0.126). Compared with statin nonusers, the fully adjusted HRs (95% CIs) for CKD in statin users were 1.014 (0.773–1.330) in males and 1.117 (0.843–1.481) in females. <b><i>Conclusion:</i></b> Dyslipidemia is an obvious risk factor for CKD; however, statin use in patients with hypercholesterolemia having normal renal function does not demonstrate a clear relationship with the incidence of CKD.
DOI: 10.6084/m9.figshare.17121434.v1
title: Supplementary Material for: Statin Use and Incidence of Chronic Kidney Disease in Hypercholesterolemia Patients with Normal Renal Function

description: <b><i>Introduction:</i></b> Dyslipidemia is a known risk factor for chronic kidney disease (CKD). The effects of statins on CKD have already been studied in patients with CKD; however, data on the general population are limited. This study aimed to determine the relationship between statin use and the incidence of CKD in patients with hypercholesterolemia having normal renal function. <b><i>Methods:</i></b> A total of 7,856 participants aged 40–79 years at baseline (2009–2010) were included in the final analyses. The participants were divided into statin users (<i>n</i> = 4,168) and statin nonusers (<i>n</i> = 3,668), according to the statin usage. The Cox proportional hazard regression model was used to evaluate the adjusted hazard ratios (HRs) with 95% confidence intervals (CIs) for CKD. <b><i>Results:</i></b> The median follow-up duration was 5.8 years. A total of 543 cases of CKD (285 cases in males and 258 cases in females) occurred during the study period. The estimated cumulative incidence of CKD was significantly different between male statin nonusers and users (<i>p</i> &lt; 0.001), while it was not statistically significant between female statin nonusers and users (<i>p</i> = 0.126). Compared with statin nonusers, the fully adjusted HRs (95% CIs) for CKD in statin users were 1.014 (0.773–1.330) in males and 1.117 (0.843–1.481) in females. <b><i>Conclusion:</i></b> Dyslipidemia is an obvious risk factor for CKD; however, statin use in patients with hypercholesterolemia having normal renal function does not demonstrate a clear relationship with the incidence of CKD.
DOI: 10.5281/zenodo.5616466
title: 3D FEM-based inverse model of Nevado del Ruiz - St. Isabel volcanoes (Colombia)

description: <strong>Description of model and data</strong> The files include a FEM-based inverse model for the optimization of parameters of a pressure source responsible for surface deformation. The investigated source parameters are the position of the source center, the three semi-axis, the source strike orientation, the source dip orientation, and the source overpressure. The observations used for the inversion are ascending and descending ground velocities. The optimization is based on Least-Squares objectives using the Monte Carlo method. The file of observations needed for the computation of the Least-Squares objectives (to be uploaded in the optimization node) requires four columns (x,y,z, velocities. All in meters, UTM coordinates-UTM zone 18N, and comma-separated). The model takes into consideration the heterogeneous distribution of material elastic properties. The model does not provide the files for the observations and material properties (at the link: https://zenodo.org/record/5575972), but the structure for the optimization model in which new files can be uploaded for a customized model. The model includes the compensation for the stresses induced by the topography (edifices’ load). The file for the construction of the topographic surface is included as a .txt file (the position x,y of the points is in UTM coordinates-UTM zone 18N, the altitude z is in meters). The far-field is modeled as a hemisphere and it is located at 35 km from the center of the model, which is between the Nevado del Ruiz volcano and Santa Isabel volcano. The model is built with Comsol Multiphysics v 5.6 using the modules Optimization and Structural Mechanics modules, and it is provided as a Comsol .mph file. Datasets and model are results of PICVOLC project. PICVOLC has received funding from the European Union’s Horizon 2020 research and innovation program under the Marie Skłodowska-Curie grant agreement No. 79381
DOI: 10.5281/zenodo.5616465
title: 3D FEM-based inverse model of Nevado del Ruiz - St. Isabel volcanoes (Colombia)

description: <strong>Description of model and data</strong> The files include a FEM-based inverse model for the optimization of parameters of a pressure source responsible for surface deformation. The investigated source parameters are the position of the source center, the three semi-axis, the source strike orientation, the source dip orientation, and the source overpressure. The observations used for the inversion are ascending and descending ground velocities. The optimization is based on Least-Squares objectives using the Monte Carlo method. The file of observations needed for the computation of the Least-Squares objectives (to be uploaded in the optimization node) requires four columns (x,y,z, velocities. All in meters, UTM coordinates-UTM zone 18N, and comma-separated). The model takes into consideration the heterogeneous distribution of material elastic properties. The model does not provide the files for the observations and material properties (at the link: https://zenodo.org/record/5575972), but the structure for the optimization model in which new files can be uploaded for a customized model. The model includes the compensation for the stresses induced by the topography (edifices’ load). The file for the construction of the topographic surface is included as a .txt file (the position x,y of the points is in UTM coordinates-UTM zone 18N, the altitude z is in meters). The far-field is modeled as a hemisphere and it is located at 35 km from the center of the model, which is between the Nevado del Ruiz volcano and Santa Isabel volcano. The model is built with Comsol Multiphysics v 5.6 using the modules Optimization and Structural Mechanics modules, and it is provided as a Comsol .mph file. Datasets and model are results of PICVOLC project. PICVOLC has received funding from the European Union’s Horizon 2020 research and innovation program under the Marie Skłodowska-Curie grant agreement No. 79381
DOI: 10.5281/zenodo.5751820
title: rime fraction training data set extracted from BAECC

description: training data set used in Vogl et al. (https://amt.copernicus.org/preprints/amt-2021-137/) to derive rime mass fraction from Doppler cloud radar observations. Extracted from the BAECC data set. rime mass fraction retrieved from PIP data cloud radar observations at Ka- and W-band (ARM KAZR and MWACR) attenuation estimated using the Passive and Active Microwave Remote Sensing Tool (PAMTRA)
DOI: 10.5281/zenodo.5751819
title: rime fraction training data set extracted from BAECC

description: training data set used in Vogl et al. (https://amt.copernicus.org/preprints/amt-2021-137/) to derive rime mass fraction from Doppler cloud radar observations. Extracted from the BAECC data set. rime mass fraction retrieved from PIP data cloud radar observations at Ka- and W-band (ARM KAZR and MWACR) attenuation estimated using the Passive and Active Microwave Remote Sensing Tool (PAMTRA)
DOI: 10.25721/ghtx-tw28
title: Information sur le charivari
DOI: 10.5519/qd.pimzr6qj
title: Query on the Natural History Museum Data Portal (data.nhm.ac.uk) (4981413 records)
DOI: 10.17632/8458pz722c.2
title: Open-source sequence validation Version 2

description: Two open-source Magnetic Resonance Imaging (MRI) sequences were coded using PyPulseq and tested at two sites to demonstrate a sequence validation framework. Sequence scripts (.ipynb notebooks),  simulated and acquired data, reconstruction and analysis scripts, as well as images are included.  Pulseq system configurations of five scanners are included for replication.
DOI: 10.5281/zenodo.5751839
title: TCGA ABSOLUTE auto-calling results with DoAbsolute

description: The results are calculated with DoAbsolute (https://github.com/ShixiangWang/DoAbsolute) with cancer type specific and pan-cancer mode based on TCGA copy number segments data and mutation data. Take your own risk as the data are auto-processed and no manual check. array sample call status purity ploidy Genome doublings delta Coverage for 80% power Cancer DNA fraction Subclonal genome fraction tau E_CR<br> TCGA-OR-A5JO-01 TCGA-OR-A5JO-01 called 1 5 0 0.2 21 1 0.01 5.00281122783359 0<br> TCGA-OR-A5KQ-10 TCGA-OR-A5KQ-10 called 0.69 5 0 0.17 29 0.85 0 4.99022535717521 0<br> TCGA-OR-A5L8-10 TCGA-OR-A5L8-10 called 0.56 3.99 0 0.18 27 0.72 0 4.02086049427876 0<br> TCGA-OU-A5PI-10 TCGA-OU-A5PI-10 called 0.75 5 0 0.18 28 0.88 0.01 5.01366221195135 0 Please cite the following paper if you use it in academic research: Wang, Shixiang, et al. "The predictive power of tumor mutational burden in lung cancer immunotherapy response is influenced by patients' sex." International journal of cancer (2019). Carter, Scott L., et al. “Absolute quantification of somatic DNA alterations in human cancer.” Nature biotechnology 30.5 (2012): 413.
DOI: 10.5281/zenodo.5751838
title: TCGA ABSOLUTE auto-calling results with DoAbsolute

description: The results are calculated with DoAbsolute (https://github.com/ShixiangWang/DoAbsolute) with cancer type specific and pan-cancer mode based on TCGA copy number segments data and mutation data. Take your own risk as the data are auto-processed and no manual check. array sample call status purity ploidy Genome doublings delta Coverage for 80% power Cancer DNA fraction Subclonal genome fraction tau E_CR<br> TCGA-OR-A5JO-01 TCGA-OR-A5JO-01 called 1 5 0 0.2 21 1 0.01 5.00281122783359 0<br> TCGA-OR-A5KQ-10 TCGA-OR-A5KQ-10 called 0.69 5 0 0.17 29 0.85 0 4.99022535717521 0<br> TCGA-OR-A5L8-10 TCGA-OR-A5L8-10 called 0.56 3.99 0 0.18 27 0.72 0 4.02086049427876 0<br> TCGA-OU-A5PI-10 TCGA-OU-A5PI-10 called 0.75 5 0 0.18 28 0.88 0.01 5.01366221195135 0 Please cite the following paper if you use it in academic research: Wang, Shixiang, et al. "The predictive power of tumor mutational burden in lung cancer immunotherapy response is influenced by patients' sex." International journal of cancer (2019). Carter, Scott L., et al. “Absolute quantification of somatic DNA alterations in human cancer.” Nature biotechnology 30.5 (2012): 413.
DOI: 10.5519/qd.ruyp405j
title: Query on the Natural History Museum Data Portal (data.nhm.ac.uk) (256 records)
DOI: 10.25500/edata.bham.00000744
title: Code for "A minimalistic approach to physics-informed machine learning using neighbour lists as physics optimized convolutions for inverse problems involving particle systems"
DOI: 10.5281/zenodo.5751831
title: Large Spin-to-Charge Conversion at Room Temperature in Extended Epitaxial Sb2Te3 Topological Insulator Chemically Grown on Silicon (data)

description: This dataset contains the raw data files connected with the figures included in the paper "<em>Large Spin-to-Charge Conversion at Room Temperature in Extended Epitaxial Sb<sub>2</sub>Te<sub>3</sub> Topological Insulator Chemically Grown on Silicon</em>" by E. Longo et al., <em>Adv. Funct. Mater.</em> 2021, 2109361
DOI: 10.5281/zenodo.5751830
title: Large Spin-to-Charge Conversion at Room Temperature in Extended Epitaxial Sb2Te3 Topological Insulator Chemically Grown on Silicon (data)

description: This dataset contains the raw data files connected with the figures included in the paper "<em>Large Spin-to-Charge Conversion at Room Temperature in Extended Epitaxial Sb<sub>2</sub>Te<sub>3</sub> Topological Insulator Chemically Grown on Silicon</em>" by E. Longo et al., <em>Adv. Funct. Mater.</em> 2021, 2109361
DOI: 10.34740/kaggle/dsv/2881934
title: The state of hiring discrimination
DOI: 10.25721/r5jf-m460
title: Information sur la traite bovine et les montagnes
DOI: 10.3886/e114835v1-103140
title: Replication data for: Beyond Work Ethic: Religion, Individual, and Political Preferences

description: We investigate the effect of Reformed Protestantism, relative to Catholicism, on preferences for leisure, and for redistribution and intervention in the economy. We use a Fuzzy Spatial Regression Discontinuity Design to exploit a historical quasi-experiment in Western Switzerland, where in the sixteenth century a hitherto homogeneous region was split and one part assigned to adopt Protestantism. We find that Reformed Protestantism reduces referenda voting for more leisure by 14, redistribution by 5, and government intervention by 7 percentage points. These preferences translate into higher per capita income as well as greater income inequality.
DOI: 10.17608/k6.auckland.14446893.v2
title: CANDID PTX images + labels

description: Actual dataset
DOI: 10.25721/sf03-t585
title: Information sur les cloches et la montée
DOI: 10.5258/soton/d2048
title: Dataset for Vaccinating the Nexus

description: Spreadsheet for quantitative literature review for VTN paper
DOI: 10.5281/zenodo.5751891
title: Data_LCSFM

description: LCSFM Data
DOI: 10.5281/zenodo.5751890
title: Data_LCSFM

description: LCSFM Data
DOI: 10.25721/aasn-xe47
title: Information sur l'identification des cloches