cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.8109116.v1
title: Scoring Depression on a Common Metric: A Comparison of EAP Estimation, Plausible Value Imputation, and Full Bayesian IRT Modeling

description: There are a growing number of item response theory (IRT) studies that calibrate different patient-reported outcome (PRO) measures, such as anxiety, depression, physical function, and pain, on common, instrument-independent metrics. In the case of depression, it has been reported that there are considerable mean score differences when scoring on a common metric from different, previously linked instruments. Ideally, those estimates should be the same. We investigated to what extent those differences are influenced by different scoring methods that take into account several levels of uncertainty, such as measurement error (through plausible value imputation) and item parameter uncertainty (through full Bayesian IRT modeling). Depression estimates from different instruments were more similar, and their corresponding confidence/credible intervals were larger when plausible value imputation or Bayesian modeling was used, compared to the direct use of expected a posteriori (EAP) estimates. Furthermore, we explored the use of Bayesian IRT models to update item parameters based on newly collected data.
DOI: 10.6084/m9.figshare.8109026
title: Metabolic perturbation of acrylate pathway in <i>Lactobacillus plantarum</i>

description: Engineering microbes with heterologous pathway for production of bio-based products has received considerable attention. Reconstituting such non-native pathway in addition to desired product formation often brings an allosteric modulation in enzymes competing at fragile nodes that result in by-product redistribution, in order to retain energy and redox balance. This work, <i>Lactobacillus plantarum</i> engineered with acrylate pathway for propionate production was studied under similar perspectives. Upon expression, the heterologous pathway did not result in propionic acid production under standard glucose concentration of 20 g/L, but 0.01 mM of propionate was formed when grown under low glucose concentration of 1 g/L. Further analysis of secreted metabolites with increased glucose concentration of 10 and 30 g/L remained futile towards propionate formation but showed reorientation in pyruvate metabolism which was related to the control imposed by the host to regulate the hidden constraints caused by gene perturbation. Further, it was ensured that the limitation of supplements did not play any functional role in inhibiting propionic acid synthesis but still followed similar metabolic pattern which was quite unclear though interpreted to certain extent. Thus, the findings gave insights into physiological and metabolic capabilities of <i>Lactobacillus plantarum</i> that at least in principle can be used to enhance the strain performance for increased propionic acid production.
DOI: 10.6084/m9.figshare.8109002
title: S2 File

description: Supplementary online material (S2 File) containing the dataset (STATA format) used in Justice Nyakura study (VL uptake among PBF on ART in Mazowe, Zimbabwe, 2017)
DOI: 10.6084/m9.figshare.8109002.v2
title: S2 File

description: Supplementary online material (S2 File) containing the dataset (STATA format) used in Justice Nyakura study (VL uptake among PBF on ART in Mazowe, Zimbabwe, 2017)
DOI: 10.6084/m9.figshare.8108972
title: Real-time wastewater monitoring as tool to detect clandestine waste discharges into the sewage system

description: The entry of illegally discharged waste into the sewage system can cause serious damage to sewage pipes and harm the public domain. Besides industrial and communal sources, discharges from clandestine laboratories are of special forensic interest. Aim of this study is to investigate the possibility to detect clandestine discharges of possibly hazardous waste directly at the point of discharge. Tests were performed at a facility where real wastewater was pumped in a controlled way through an open sewage pipe above ground. Chloride, ammonia, pH and conductivity electrodes were investigated for their ability to detect discharges of different types of waste. Waste samples were diluted up to 50 times in a static wastewater environment and pH, conductivity and chloride electrodes were able to distinguish all waste dilutions from blank wastewater. These three electrodes were then used for dynamic tests by placing them inside flowing sewage water and discharging different types of liquid waste ten meters upstream of them. Parameters of the waste discharges like volume, time interval and speed of discharge were varied and the responses of the electrodes were collected. The dynamic tests showed that these three electrodes were able to pick up different waste discharges in a real wastewater environment. It was found that a high sampling rate of the sensors would be required to connect a certain discharge to a specific household connection. These findings highlight the possibility to locate illegal discharges, coming from a variety of sources, using the waste discharge itself.
DOI: 10.6084/m9.figshare.8109026.v2
title: Metabolic perturbation of acrylate pathway in <i>Lactobacillus plantarum</i>

description: Engineering microbes with heterologous pathway for production of bio-based products has received considerable attention. Reconstituting such non-native pathway in addition to desired product formation often brings an allosteric modulation in enzymes competing at fragile nodes that result in by-product redistribution, in order to retain energy and redox balance. This work, <i>Lactobacillus plantarum</i> engineered with acrylate pathway for propionate production was studied under similar perspectives. Upon expression, the heterologous pathway did not result in propionic acid production under standard glucose concentration of 20 g/L, but 0.01 mM of propionate was formed when grown under low glucose concentration of 1 g/L. Further analysis of secreted metabolites with increased glucose concentration of 10 and 30 g/L remained futile towards propionate formation but showed reorientation in pyruvate metabolism which was related to the control imposed by the host to regulate the hidden constraints caused by gene perturbation. Further, it was ensured that the limitation of supplements did not play any functional role in inhibiting propionic acid synthesis but still followed similar metabolic pattern which was quite unclear though interpreted to certain extent. Thus, the findings gave insights into physiological and metabolic capabilities of <i>Lactobacillus plantarum</i> that at least in principle can be used to enhance the strain performance for increased propionic acid production.
DOI: 10.6084/m9.figshare.8108972.v1
title: Real-time wastewater monitoring as tool to detect clandestine waste discharges into the sewage system

description: The entry of illegally discharged waste into the sewage system can cause serious damage to sewage pipes and harm the public domain. Besides industrial and communal sources, discharges from clandestine laboratories are of special forensic interest. Aim of this study is to investigate the possibility to detect clandestine discharges of possibly hazardous waste directly at the point of discharge. Tests were performed at a facility where real wastewater was pumped in a controlled way through an open sewage pipe above ground. Chloride, ammonia, pH and conductivity electrodes were investigated for their ability to detect discharges of different types of waste. Waste samples were diluted up to 50 times in a static wastewater environment and pH, conductivity and chloride electrodes were able to distinguish all waste dilutions from blank wastewater. These three electrodes were then used for dynamic tests by placing them inside flowing sewage water and discharging different types of liquid waste ten meters upstream of them. Parameters of the waste discharges like volume, time interval and speed of discharge were varied and the responses of the electrodes were collected. The dynamic tests showed that these three electrodes were able to pick up different waste discharges in a real wastewater environment. It was found that a high sampling rate of the sensors would be required to connect a certain discharge to a specific household connection. These findings highlight the possibility to locate illegal discharges, coming from a variety of sources, using the waste discharge itself.
DOI: 10.6084/m9.figshare.8109002.v1
title: S2 Annex

description: Supplementary online material (S2 Annex) containing the dataset used in Justice Nyakura (VL uptake among PBF on ART in Mazowe, Zimbabwe, 2017)
DOI: 10.6084/m9.figshare.8108831
title: Raw data for Eacock et al (2019) Adaptive colour change and background choice behaviour in peppered moth caterpillars is mediated by extraocular photoreception

description: Raw data for Eacock et al (2019) Adaptive colour change and background choice behaviour in peppered moth caterpillars is mediated by extraocular photoreception.
DOI: 10.6084/m9.figshare.8108831.v1
title: Raw data for Eacock et al (2019) Adaptive colour change and background choice behaviour in peppered moth caterpillars is mediated by extraocular photoreception

description: Raw data for Eacock et al (2019) Adaptive colour change and background choice behaviour in peppered moth caterpillars is mediated by extraocular photoreception.
DOI: 10.6084/m9.figshare.8108357
title: gammaBOriS Training Datasets

description: Positive and negative dataset created for training of machine learning models to classify/identify gammaproteobacterial oriC sequences. Sequences are in FASTA format.Seed sequence dataset extracted from the positive sequence file in FASTA format.<br>
DOI: 10.6084/m9.figshare.8108297
title: OGW_CFRP_Temperature_udam

description: OGW_CFRP_Temperature_udam
DOI: 10.6084/m9.figshare.8108357.v1
title: BOriS Training Datasets

description: Positive and negative dataset created for training of machine learning models to classify/identify gammaproteobacterial oriC sequences.<br>
DOI: 10.6084/m9.figshare.8108297.v1
title: OGW_CFRP_Temperature_udam

description: OGW_CFRP_Temperature_udam
DOI: 10.6084/m9.figshare.8108207
title: Reshaping our understanding of species’ roles in landscape-scale networks

description: Data associate with Ecology Letters manuscript number: ELE-01021-2018.R2; Hackett et al. Reshaping our understanding of species’ roles in landscape-scale networks<br>See READ ME text file for specific detail
DOI: 10.6084/m9.figshare.8108219
title: Late mucosal ulcers in dose-escalated adaptive dose-painting treatments for head-and-neck cancer

description: <b>Background:</b> To identify predictive factors for the development of late grade 4 mucosal ulcers in adaptive dose-escalated treatments for head-and-neck cancer. <b>Material and methods:</b> Patient data of four dose-escalated three-phase adaptive dose-painting by numbers (DPBN) clinical trials were analyzed in this study. Correlations between the development of late grade 4 ulcers and factors related with the treatment, disease characteristics and the patient were investigated. Dosimetrical thresholds were searched among the highest doses received by 1.75 cm<sup>3</sup> (D<sub>1.75cc</sub>) of the primary gross tumor volume (GTV<sub>T</sub>) and the corresponding normalized isoeffective dose (NID2<sub>1.75cc</sub>, with a reference dose of 2Gy/fraction and α/β of 3 Gy). <b>Results:</b> From 39 studied patients, nine developed late grade 4 mucosal ulcers. The continuation to either smoke or drink alcohol after therapy was the factor that showed a strong (eight out of nine patients) association with the occurrence of grade 4 ulcers. Six of the patients who continued to smoke or/and drink had D<sub>1.75cc</sub> and NID2<sub>1.75cc</sub> above 84 Gy and 95.5 Gy, respectively. Seven of the patients with grade 4 had the dose levels above these thresholds, but even if the D<sub>1.75cc</sub> threshold was significant in the prediction of late grade 4 ulcers, it could not be considered as the only contributing factor. <b>Conclusions:</b> The search for patterns provided strong reasons to apply a dosimetrical threshold for the peak-dose volume of 1.75 cm<sup>3</sup> as a preventive measure for late grade 4 mucosal ulcers. Also, patients that continue to smoke or drink alcohol after therapy have increased risk to develop late mucosal ulcers.
DOI: 10.6084/m9.figshare.8108219.v1
title: Late mucosal ulcers in dose-escalated adaptive dose-painting treatments for head-and-neck cancer

description: <b>Background:</b> To identify predictive factors for the development of late grade 4 mucosal ulcers in adaptive dose-escalated treatments for head-and-neck cancer. <b>Material and methods:</b> Patient data of four dose-escalated three-phase adaptive dose-painting by numbers (DPBN) clinical trials were analyzed in this study. Correlations between the development of late grade 4 ulcers and factors related with the treatment, disease characteristics and the patient were investigated. Dosimetrical thresholds were searched among the highest doses received by 1.75 cm<sup>3</sup> (D<sub>1.75cc</sub>) of the primary gross tumor volume (GTV<sub>T</sub>) and the corresponding normalized isoeffective dose (NID2<sub>1.75cc</sub>, with a reference dose of 2Gy/fraction and α/β of 3 Gy). <b>Results:</b> From 39 studied patients, nine developed late grade 4 mucosal ulcers. The continuation to either smoke or drink alcohol after therapy was the factor that showed a strong (eight out of nine patients) association with the occurrence of grade 4 ulcers. Six of the patients who continued to smoke or/and drink had D<sub>1.75cc</sub> and NID2<sub>1.75cc</sub> above 84 Gy and 95.5 Gy, respectively. Seven of the patients with grade 4 had the dose levels above these thresholds, but even if the D<sub>1.75cc</sub> threshold was significant in the prediction of late grade 4 ulcers, it could not be considered as the only contributing factor. <b>Conclusions:</b> The search for patterns provided strong reasons to apply a dosimetrical threshold for the peak-dose volume of 1.75 cm<sup>3</sup> as a preventive measure for late grade 4 mucosal ulcers. Also, patients that continue to smoke or drink alcohol after therapy have increased risk to develop late mucosal ulcers.
DOI: 10.6084/m9.figshare.8108180
title: The earliest fossil record of Belidae and its implications for the early evolution of Curculionoidea (Coleoptera)

description: Here we report the earliest known fossil belid, <i>Sinoeuglypheus daohugouensis</i> gen. et sp. nov., from the latest Middle Jurassic Jiulongshan Formation of north-eastern China. Extant belids are specialist herbivores feeding on gymnosperms or angiosperms, but it is likely that this new belid fed on coexisting conifers or other gymnosperms. Extant members of Belidae are predominantly distributed in the Southern Hemisphere. Therefore, this new find in the north-eastern China deposit is significant for understanding the early stages of the radiation of this group during the mid-Mesozoic, and the early evolution of Curculionoidea. http://zoobank.org/urn:lsid:zoobank.org:pub:2020E35D-E918-4C84-993C-20B8E4DBB671
DOI: 10.6084/m9.figshare.8108171
title: Older adults’ perspectives on the process of becoming users of assistive technology: a qualitative systematic review and meta-synthesis

description: <b>Purpose:</b> To identify, synthesize, and evaluate existing literature concerning the process of becoming a user of assistive technology (AT). <b>Method:</b> A systematic review and meta-synthesis were carried out. Five bibliographic databases (MEDLINE via PubMed, CINAHL, Web of Science, PsycINFO and SocINDEX) were systematically searched up to 13<sup>th</sup> of March 2017, using two sets of search terms: (i) elderly and synonyms and (ii) assistive technology and similar words, and combined with a qualitative research filter. Articles were screened, read and critically assessed. The meta-synthesis was guided by Ricoeur’s theory of interpretation. <b>Results:</b> Seventeen out of 4645 articles were included. Five phases emerged relating to the process of becoming a user of AT: phase A: Evaluating need, phase B: Acknowledging need, phase C: Incorporating the AT into daily life, phase D: Using the AT, and phase E: Future use. Three transitions, describing factors essential to moving from one phase to the next, were identified; from phase A–B: Valued activities are threatened, from phase B–C: Obtaining the AT and from phase C–D: Trust in the AT. No transition was identified from phase D–E. <b>Conclusion:</b> The meta-synthesis led to a deeper understanding of the process of older adults becoming users of AT, by exploring findings across the included articles. The identified phases and transitions in the systematic review serve as an analytical framework for understanding the process from the older adult’s perspective. This review advocates for using a client-centred approach throughout the entire delivery process.Implications for rehabilitationThe process of the older adult becoming a user of AT involves an individualized time factor, and this supports the practice of individualized follow-up.The process of becoming a user of AT is closely related to self-image; healthcare professionals should support not only the use of AT but also the older adult’s emotional adjustment to a new self-image.The process is highly influenced by the older adult’s social context; healthcare professionals should consider involving the client’s social network in the AT delivery process. The process of the older adult becoming a user of AT involves an individualized time factor, and this supports the practice of individualized follow-up. The process of becoming a user of AT is closely related to self-image; healthcare professionals should support not only the use of AT but also the older adult’s emotional adjustment to a new self-image. The process is highly influenced by the older adult’s social context; healthcare professionals should consider involving the client’s social network in the AT delivery process.
DOI: 10.6084/m9.figshare.8108180.v1
title: The earliest fossil record of Belidae and its implications for the early evolution of Curculionoidea (Coleoptera)

description: Here we report the earliest known fossil belid, <i>Sinoeuglypheus daohugouensis</i> gen. et sp. nov., from the latest Middle Jurassic Jiulongshan Formation of north-eastern China. Extant belids are specialist herbivores feeding on gymnosperms or angiosperms, but it is likely that this new belid fed on coexisting conifers or other gymnosperms. Extant members of Belidae are predominantly distributed in the Southern Hemisphere. Therefore, this new find in the north-eastern China deposit is significant for understanding the early stages of the radiation of this group during the mid-Mesozoic, and the early evolution of Curculionoidea. http://zoobank.org/urn:lsid:zoobank.org:pub:2020E35D-E918-4C84-993C-20B8E4DBB671
DOI: 10.6084/m9.figshare.8108141
title: Supplementary Material for: Intensive versus Usual Control of Hypertension in the Prevention of Cardiovascular and Renal Outcomes: A Cumulative Meta-Analysis of Randomized Controlled Trials

description: <b><i>Background/Aims:</i></b> Previous studies have reported inconsistent results regarding the treatment effects of intensive blood pressure (IBP) control in the prevention of cardiovascular and renal outcomes. We conducted this cumulative meta-analysis to evaluate the treatment effects of IBP control on cardiovascular and renal outcomes. <b><i>Methods:</i></b> We systematically searched PubMed, EMBASE, and the Cochrane Library databases from the date of their inception to October 2017, to identify randomized controlled trials (RCTs). The relative risks (RRs) with corresponding 95% confidence intervals (CIs) were used to evaluate the treatment effects of IBP control by using a random-effects model. <b><i>Results:</i></b> The final analysis included 20 RCTs involving 56,687 individuals. The summary RRs indicated that IBP control treatment significantly reduced the risk of major cardiovascular events (RR: 0.85; 95% CI: 0.77–0.94; <i>p</i> = 0.001), including myocardial infarction (RR: 0.87; 95% CI: 0.76–1.00; <i>p</i> = 0.044), stroke (RR: 0.77; 95% CI: 0.66–0.89; <i>p</i> &lt; 0.001), and albuminuria (RR: 0.90; 95% CI: 0.84–0.97; <i>p</i> = 0.007). However, IBP control had no significant effect on heart failure (RR: 0.80; 95% CI: 0.62–1.03; <i>p</i> = 0.077), all-cause mortality (RR: 0.91; 95% CI: 0.81–1.02; <i>p</i> = 0.112), cardiac death (RR: 0.91; 95% CI: 0.75–1.12; <i>p</i> = 0.390), non-cardiac death (RR: 0.98; 95% CI: 0.86–1.12; <i>p</i> = 0.773), end-stage renal disease (RR: 0.90; 95% CI: 0.77–1.06; <i>p</i> = 0.203), and retinopathy (RR: 0.81; 95% CI: 0.66–1.00; <i>p</i> = 0.052). <b><i>Conclusion:</i></b> The findings of this study suggest that IBP control plays a beneficial role in the prevention of some major cardiovascular events, including myocardial infarction, stroke, and albuminuria.
DOI: 10.6084/m9.figshare.8108165
title: Data set 2_Results table.xlsx

description: Bordetella pertussis proteins identified in analyzed aPv and wPv vaccines.
DOI: 10.6084/m9.figshare.8108171.v1
title: Older adults’ perspectives on the process of becoming users of assistive technology: a qualitative systematic review and meta-synthesis

description: <b>Purpose:</b> To identify, synthesize, and evaluate existing literature concerning the process of becoming a user of assistive technology (AT). <b>Method:</b> A systematic review and meta-synthesis were carried out. Five bibliographic databases (MEDLINE via PubMed, CINAHL, Web of Science, PsycINFO and SocINDEX) were systematically searched up to 13<sup>th</sup> of March 2017, using two sets of search terms: (i) elderly and synonyms and (ii) assistive technology and similar words, and combined with a qualitative research filter. Articles were screened, read and critically assessed. The meta-synthesis was guided by Ricoeur’s theory of interpretation. <b>Results:</b> Seventeen out of 4645 articles were included. Five phases emerged relating to the process of becoming a user of AT: phase A: Evaluating need, phase B: Acknowledging need, phase C: Incorporating the AT into daily life, phase D: Using the AT, and phase E: Future use. Three transitions, describing factors essential to moving from one phase to the next, were identified; from phase A–B: Valued activities are threatened, from phase B–C: Obtaining the AT and from phase C–D: Trust in the AT. No transition was identified from phase D–E. <b>Conclusion:</b> The meta-synthesis led to a deeper understanding of the process of older adults becoming users of AT, by exploring findings across the included articles. The identified phases and transitions in the systematic review serve as an analytical framework for understanding the process from the older adult’s perspective. This review advocates for using a client-centred approach throughout the entire delivery process.Implications for rehabilitationThe process of the older adult becoming a user of AT involves an individualized time factor, and this supports the practice of individualized follow-up.The process of becoming a user of AT is closely related to self-image; healthcare professionals should support not only the use of AT but also the older adult’s emotional adjustment to a new self-image.The process is highly influenced by the older adult’s social context; healthcare professionals should consider involving the client’s social network in the AT delivery process. The process of the older adult becoming a user of AT involves an individualized time factor, and this supports the practice of individualized follow-up. The process of becoming a user of AT is closely related to self-image; healthcare professionals should support not only the use of AT but also the older adult’s emotional adjustment to a new self-image. The process is highly influenced by the older adult’s social context; healthcare professionals should consider involving the client’s social network in the AT delivery process.