cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.15156/bio/sh0792921.10fu
title: SH0792921.10FU

description: UNITE provides a unified way for delimiting, identifying, communicating, and working with DNA-based Species Hypotheses (SH). All fungal ITS sequences in the international nucleotide sequence databases are clustered to approximately the species level by applying a set of dynamic distance values (<0.5 - 3.0%). All species hypotheses are given a unique, stable name in the form of a DOI, and their taxonomic and ecological annotations are verified through distributed, web-based third-party annotation efforts. SHs are connected to a taxon name and its classification as far as possible (phylum, class, order, etc.) by taking into account identifications for all sequences in the SH. An automatically or manually designated sequence is chosen to represent each such SH. These sequences are released (https://unite.ut.ee/repository.php) for use by the scientific community in, for example, local sequence similarity searches and next-generation sequencing analysis pipelines. The system and the data are updated automatically as the number of public fungal ITS sequences grows.
DOI: 10.6084/m9.figshare.22591591
title: Supplementary Material for: In utero exposure to valproic acid throughout pregnancy causes phenotypes of autism in offspring mice

description: Valproic acid (VPA) is an antiepileptic drug that inhibits the epileptic activity of neurons mainly by inhibiting sodium channels and GABA transaminase. VPA is also known to inhibit histone deacetylases, which epigenetically modify the cell proliferation/differentiation characteristics of stem/progenitor cells within developing tissues. Recent clinical studies in humans have indicated that VPA exposure in utero increases the risk of autistic features and intellectual disabilities in offspring; we previously reported that low-dose VPA exposure in utero throughout pregnancy increases the production of projection neurons from neuronal stem/progenitor cells that are distributed in the superficial neocortical layers of the fetal brain. In the present study, we found that in utero VPA-exposed mice exhibited abnormal social interaction, changes in cognitive function, hypersensitivity to pain/heat, and impaired locomotor activity, all of which are characteristic symptoms of autistic spectrum disorder in humans. Taken together, our findings indicate that VPA exposure in utero throughout pregnancy alters higher brain function and predisposes individuals to phenotypes that resemble autism and intellectual disability. Furthermore, these symptoms are likely to be due to neocortical dysgenesis that was caused by an increased number of projection neurons in specific layers of the neocortex.
DOI: 10.6084/m9.figshare.22650688
title: Supplementary Material for: Identification of inflammatory endotypes by clinical characteristics and nasal secretion biomarkers in chronic rhinosinusitis with nasal polyps

description: Introduction: The emergency of biologics and surgical techniques targeting the specific inflammatory endotype in chronic rhinosinusitis with nasal polyps (CRSwNP) asks for efficient identification of patients with different endotypes. Although mucosal IL-4, IL-5, IL-13, and IgE have been used to define type 2 (T2) inflammation, the optimal one remains unclear. In this study, we aimed to determine the optimal anchor for T2 inflammation and identify clinical characteristics and nasal secretion biomarkers predicting different endotypes in CRSwNP. Methods: Six mediators in sinonasal tissue and 36 mediators in nasal secretion samples were detected by the Bio-Plex suspension array system. Mucosal IFN-γ and IL-17A levels were used to define the T1 and T3 endotype, respectively. The efficacy of mucosal IL-4, IL-5, IL-13, and IgE to define the T2 endotype was compared. The power of clinical characteristics and nasal secretion biomarkers to predict the T1, T2, and T3 endotype was analyzed. Results: Among mucosal IL-4, IL-5, IL-13, and IgE, IL-13 was the best one to coincide with the expression of other T2 biomarkers. A combination of atopy, facial pain symptom score, ethmoid/maxillary computed tomography score ratio, and blood eosinophil percentage had a moderate predictive performance for T2 endotype (AUC = 0.815), comparable to that of nasal secretion IL-5 (AUC = 0.819). For the T3 endotype, nasal secretion IL-1Rα identified it with an AUC value of 0.756. No efficient marker for the T1 endotype was found. Conclusion: IL-13 is a primary anchor for the T2 endotype in CRSwNP. Clinical characteristics and nasal secretion biomarkers are helpful for identifying the T2 and T3 endotype of CRSwNP.
DOI: 10.6084/m9.figshare.23181032
title: Supplementary Material for: Identifying risk factors of complications following total gastrectomy for gastric cancer – comparison between splenectomy and spleen-preserving surgery: a supplementary analysis of JCOG0110

description: Introduction: Splenectomy for proximal gastric cancer was found to offer no survival benefit in a randomized trial clarifying the role of splenectomy (JCOG0110 study). Although many studies have explored risk factors for morbidities following total gastrectomy, none have assessed the risk factors for postoperative complications in spleen preserving total gastrectomy. Methods: Using data from 505 patients enrolled in a previous randomized trial, risk factors for postoperative complications were identified by multivariable logistic regression analysis. Then, the risk factors were assessed separately between splenectomy and spleen preserving total gastrectomy. Results: Postoperative complications were identified in 119 patients (23.6%) and were more common following splenectomy than following spleen-preserving surgery (30.7% and 16.1% respectively, P&lt;0.01). Multivariable analysis revealed that age ≥65 years (P = 0.032), body mass index ≥25 (P = 0.003), and blood loss ≥350 g (P = 0.019) were independent risk factors for postoperative complications in the entire cohort. Among them, only body mass index was a significant independent risk factor for complications in both spleen preservation (P = 0.047) and splenectomy groups (P = 0.017). Conclusion: Risk factors for postoperative complications were essentially the same between splenectomy and spleen preservation. Being overweight increased the risk of postoperative complications in spleen-preserving total gastrectomy.
DOI: 10.6084/m9.figshare.23309258
title: Supplementary Material for: Analysis of Multimorbidity of Moderate to Severe Allergic Rhinitis in Children: A Real-World Study

description: <b><i>Introduction:</i></b> Allergic rhinitis (AR) in children is associated with various comorbidities, posing challenges for treatment and management. There have been few investigations of these multimorbidities in Chinese children with AR. Here, we investigated the prevalence of multimorbidities in children with moderate to severe AR and analyzed the influencing factors using real-world data. <b><i>Methods:</i></b> In total, 600 children who visited the outpatient clinic of our hospital and were diagnosed with moderate-severe AR were prospectively enrolled. All children underwent allergen detection and electronic nasopharyngoscopy. Parents or guardians completed a questionnaire that included age, sex, mode of delivery, feeding pattern, and familial history of allergy. The multimorbidities investigated included atopic dermatitis (AD), asthma, allergic conjunctivitis (AC), chronic rhinosinusitis (CRS), adenoid hypertrophy (AH), tonsil hypertrophy (TH), recurrent epistaxis, and recurrent respiratory tract infections (RRTIs). <b><i>Results:</i></b> The AR multimorbidities reported in children were as follows: recurrent epistaxis (46.5%), AC (46.3%), AD (40.7%), asthma (22.5%), RRIs (21.3%), CRS (20.5%), AH (19.7%), and TH (12.5%). In univariate logistic regression analysis, age (&lt;6 years), birth mode, familial history of allergy, and single dust mite allergy were associated with AR multimorbidity (<i>p</i> &lt; 0.05). Multivariate logistic regression revealed that a familial history of allergy was an independent risk factor for AC (odds ratio [OR] = 1.539, 95% confidence interval [CI]: 1.104–2.145) and AH (OR = 1.506, 95% CI: 1.000–2.267) (<i>p</i> &lt; 0.05). Age (&lt;6 years) was independently associated with the risk of AD (OR = 1.405, 95% CI: 1.003–1.969) and RRTIs (OR = 1.869, 95% CI: 1.250–2.793) (<i>p</i> &lt; 0.05), cesarean section with AR and CRS risk (OR = 1.678, 95% CI: 1.100–2.561), and single dust mite allergy with asthma (OR = 1.590, 95% CI: 1.040–2.432) and CRS (OR = 1.600, 95% CI: 1.018–2.515) risk (<i>p</i> &lt; 0.05). Further, non-dust mite allergy was independently associated with AR and CRS (OR = 2.056, 95% CI: 1.084–3.899). <b><i>Conclusion:</i></b> AR was found to be accompanied by different comorbidities, including both allergic and non-allergic comorbidities, complicating disease treatment. These findings demonstrated that age (&lt;6 years), familial history of allergy, types of allergens, and cesarean section were risk factors for different multimorbidities associated with AR.
DOI: 10.6084/m9.figshare.23599779
title: Supplementary Material for: Mortality and Risk Factors in Very Elderly Patients Who Start Hemodialysis: Korean Renal Data System, 2016–2020

description: <b><i>Introduction:</i></b> The number of elderly patients with end-stage renal disease (ESRD) is increasing worldwide. However, decision-making about elderly patients with ESRD remains complex because of the lack of studies, especially in very elderly patients (≥75 years). We examined the characteristics of very elderly patients starting hemodialysis (HD) and the associated mortality and prognostic factors. <b><i>Methods:</i></b> Data were analyzed retrospectively using a nationwide cohort registry, the Korean Renal Data System. Patients who started HD between January 2016 and December 2020 were included and divided into three groups according to age at HD initiation (&lt;65, 65–74, and ≥75 years). The primary outcome was all-cause mortality during the study period. Risk factors for mortality were analyzed using Cox proportional hazard models. <b><i>Results:</i></b> In total, 22,024 incident patients were included with 10,006, 5,668, and 6,350 in each group (&lt;65, 65–74, and ≥75 years, respectively). Among the very elderly group, women had a higher cumulative survival rate than men. The survival rate was lower in patients with vascular access via a catheter than in those with an arteriovenous fistula or graft. Very elderly patients with more comorbid diseases had a significantly lower survival rate than those with fewer comorbidities. In the multivariate Cox models, old age, cancer presence, catheter use, low body mass index, low Kt/V, low albumin concentration, and capable status of partial self-care were associated with high risk of mortality. <b><i>Conclusion:</i></b> Preparation of an arteriovenous fistula or graft when starting HD should be considered in very elderly patients with fewer comorbid diseases.
DOI: 10.6084/m9.figshare.24288052
title: Supplementary Material for: Successful Combination of Olaparib and 225Ac-Dotatate in a Patient with NET G3 and BRCA mutation

description: Based on the results of the NETTER-1 trial, peptide receptor radionuclide therapy (PRRT) with Lutetium-177 (177Lu) –DOTATATE is authorized for the treatment of neuroendocrine tumors (NET) grade 1 (G1) and G2 of the intestine. After the failure of 177Lu‑DOTATATE, targeted alpha‑particle therapy (TAT) may be a possible treatment option. Here, we present a patient with cancer of unknown primary (CUP) NET G2 later G3. The patient was referred to our hospital with urosepsis due to a second-degree urinary retention. After stent insertion, a contrast-enhanced computed tomography (CT) revealed a huge pelvic tumor without metastasis. Initially the patient had undergone surgical treatment. Later the patient developed liver metastasis and was treated by 177Lu‑DOTATATE therapy and four lines of systemic therapy. A disease progression was observed and with the knowledge of a germline BRCA1 mutation, the patient was treated with TAT (Actinium-225 (225Ac)-DOTATATE) combined with olaparib. The patient achieved a significant treatment response for 12 month indicating that a combination therapy with an alpha emitter plus olaparib might deserve further investigations in clinical trials.
DOI: 10.25345/c5gb1xt2k
title: MassIVE MSV000093179 - 20231024-BacillusMEC-MelonLeaves-Luisa-Alicia
title: Samples of melon leaves treated with Bacillus ECM. Extracted with methanol 80%
DOI: 10.6084/m9.figshare.23648433
title: The potential causal association between systemic lupus erythematosus and endocrine and metabolic disorders in the East Asian population: A bidirectional two-sample Mendelian randomization study

description: <strong>Supplementary Table 1：</strong>Details of 23 SNPs used as IVs for MR analysis of SLE on GD. <strong>Supplementary Table 2：</strong>Details of 25 SNPs used as IVs for MR analysis of SLE on T2DM. <strong>Supplementary Table 3：</strong>Details of 27 SNPs used as IVs for MR analysis of SLE on OP. <strong>Supplementary Table 4：</strong>Details of 7 SNPs used as IVs for MR analysis of GD on SLE. <strong>Supplementary Table 5：</strong>Details of 74 SNPs used as IVs for MR analysis of T2DM on SLE. <strong>Supplementary Table 6：</strong>Details of 35 SNPs used as IVs for MR analysis of OP on SLE. <strong>Supplementary Table 7：</strong>Results of MR analysis for the causal effect of SLE on GD. <strong>Supplementary Table 8：</strong>Results of MR analysis for the causal effect of SLE on T2DM. <strong>Supplementary Table 9：</strong>Results of MR analysis for the causal effect of SLE on OP. <strong>Supplementary Table 10：</strong>Results of MR analysis for the causal effect of GD on SLE. <strong>Supplementary Table 11：</strong>Results of MR analysis for the causal effect of T2DM on SLE. <strong>Supplementary Table 12：</strong>Results of MR analysis for causal effect of OP on SLE. <strong>Supplementary Figure 1: </strong>Scatter plots of causal effect estimates for SLE on GD (A), GD on SLE (B), SLE on T2DM (C), T2DM on SLE (D), SLE on OP (E), OP on SLE (F). <strong>Supplementary Figure 2: </strong>(A) Leave-one-out plot of the estimates from genetically predicted SLE on GD; (B) forest plot of the estimates from genetically predicted SLE on GD; (C) Leave-one-out plot of the estimates from genetically predicted GD on SLE; (B) forest plot of the estimates from genetically predicted GD on SLE. <strong>Supplementary Figure 3: </strong>(A) Leave-one-out plot of the estimates from genetically predicted SLE on T2DM; (B) forest plot of the estimates from genetically predicted SLE on T2DM; (C) Leave-one-out plot of the estimates from genetically predicted T2DM on SLE; (D) forest plot of the estimates from genetically predicted T2DM on SLE. <strong>Supplementary Figure 4:</strong> (A) Leave-one-out plot of the estimates from genetically predicted SLE on OP; (B) forest plot of the estimates from genetically predicted SLE on OP; (C) Leave-one-out plot of the estimates from genetically predicted OP on SLE; (D) forest plot of the estimates from genetically predicted OP on SLE. <strong>Supplementary Figure 5: </strong>Funnel plots of causal effect estimates for SLE on GD (A), GD on SLE (B), SLE on T2DM (C), T2DM on SLE (D), SLE on OP (E), OP on SLE (F).
DOI: 10.6084/m9.figshare.23648433.v1
title: The potential causal association between systemic lupus erythematosus and endocrine and metabolic disorders in the East Asian population: A bidirectional two-sample Mendelian randomization study

description: <strong>Supplementary Table 1：</strong>Details of 23 SNPs used as IVs for MR analysis of SLE on GD. <strong>Supplementary Table 2：</strong>Details of 25 SNPs used as IVs for MR analysis of SLE on T2DM. <strong>Supplementary Table 3：</strong>Details of 27 SNPs used as IVs for MR analysis of SLE on OP. <strong>Supplementary Table 4：</strong>Details of 7 SNPs used as IVs for MR analysis of GD on SLE. <strong>Supplementary Table 5：</strong>Details of 74 SNPs used as IVs for MR analysis of T2DM on SLE. <strong>Supplementary Table 6：</strong>Details of 35 SNPs used as IVs for MR analysis of OP on SLE. <strong>Supplementary Table 7：</strong>Results of MR analysis for the causal effect of SLE on GD. <strong>Supplementary Table 8：</strong>Results of MR analysis for the causal effect of SLE on T2DM. <strong>Supplementary Table 9：</strong>Results of MR analysis for the causal effect of SLE on OP. <strong>Supplementary Table 10：</strong>Results of MR analysis for the causal effect of GD on SLE. <strong>Supplementary Table 11：</strong>Results of MR analysis for the causal effect of T2DM on SLE. <strong>Supplementary Table 12：</strong>Results of MR analysis for causal effect of OP on SLE. <strong>Supplementary Figure 1: </strong>Scatter plots of causal effect estimates for SLE on GD (A), GD on SLE (B), SLE on T2DM (C), T2DM on SLE (D), SLE on OP (E), OP on SLE (F). <strong>Supplementary Figure 2: </strong>(A) Leave-one-out plot of the estimates from genetically predicted SLE on GD; (B) forest plot of the estimates from genetically predicted SLE on GD; (C) Leave-one-out plot of the estimates from genetically predicted GD on SLE; (B) forest plot of the estimates from genetically predicted GD on SLE. <strong>Supplementary Figure 3: </strong>(A) Leave-one-out plot of the estimates from genetically predicted SLE on T2DM; (B) forest plot of the estimates from genetically predicted SLE on T2DM; (C) Leave-one-out plot of the estimates from genetically predicted T2DM on SLE; (D) forest plot of the estimates from genetically predicted T2DM on SLE. <strong>Supplementary Figure 4:</strong> (A) Leave-one-out plot of the estimates from genetically predicted SLE on OP; (B) forest plot of the estimates from genetically predicted SLE on OP; (C) Leave-one-out plot of the estimates from genetically predicted OP on SLE; (D) forest plot of the estimates from genetically predicted OP on SLE. <strong>Supplementary Figure 5: </strong>Funnel plots of causal effect estimates for SLE on GD (A), GD on SLE (B), SLE on T2DM (C), T2DM on SLE (D), SLE on OP (E), OP on SLE (F).
DOI: 10.6084/m9.figshare.22658874
title: Bias adjustment to preserve changes in variability: the unbiased mapping of GCM changes

description: Standard quantile mapping (QM) performs well, as a bias adjustment method, in removing historical climate biases, but it can significantly alter a global climate model (GCM) signal. Methods that do incorporate GCM changes commonly consider mean changes only. Quantile delta mapping (QDM) is an exception, as it explicitly preserves relative changes in the quantiles, but it might present biases in preserving GCMs changes in standard deviation. In this work we propose the unbiased quantile mapping (UQM) method, which by construction preserves GCM changes of the mean and the standard deviation. Synthetic experiments and four Chilean locations are used to compare the performance of UQM against QDM, QM, detrended quantile mapping, and scale distribution mapping. All the methods outperform QM, but a tradeoff exists between preserving the GCM relative changes in the quantiles (QDM is recommended in this case), or changes in the GCM moments (UQM is recommended in this case).
DOI: 10.6084/m9.figshare.22658874.v1
title: Bias adjustment to preserve changes in variability: the unbiased mapping of GCM changes

description: Standard quantile mapping (QM) performs well, as a bias adjustment method, in removing historical climate biases, but it can significantly alter a global climate model (GCM) signal. Methods that do incorporate GCM changes commonly consider mean changes only. Quantile delta mapping (QDM) is an exception, as it explicitly preserves relative changes in the quantiles, but it might present biases in preserving GCMs changes in standard deviation. In this work we propose the unbiased quantile mapping (UQM) method, which by construction preserves GCM changes of the mean and the standard deviation. Synthetic experiments and four Chilean locations are used to compare the performance of UQM against QDM, QM, detrended quantile mapping, and scale distribution mapping. All the methods outperform QM, but a tradeoff exists between preserving the GCM relative changes in the quantiles (QDM is recommended in this case), or changes in the GCM moments (UQM is recommended in this case).
DOI: 10.6084/m9.figshare.22801691
title: Use of a national flood mark database to estimate flood hazard in the distant past

description: A national flood mark database spanning several centuries contains valuable information to characterize ancient flood events. However, the network of flood mark sites is distinct from the network of hydrometric stations, making this information difficult to use. This work describes a probabilistic model jointly describing flood marks at sites and flood peaks at stations. The model is based on the estimation of hidden climate indices driving both flood marks and peaks: this allows transferring information between the two variables despite them being measured on distinct networks. The model is applied to about 300 flood mark sites (1705–2015) and 200 stations (1904–2015) in France. Results demonstrate that flood marks allow estimating the time-varying probability of exceeding some high discharge threshold at stations during the whole period 1705–2015, which largely predates the existence of stations. The resulting probability maps provide quantitative information on the extent and spatial structure of ancient floods.
DOI: 10.6084/m9.figshare.22801691.v1
title: Use of a national flood mark database to estimate flood hazard in the distant past

description: A national flood mark database spanning several centuries contains valuable information to characterize ancient flood events. However, the network of flood mark sites is distinct from the network of hydrometric stations, making this information difficult to use. This work describes a probabilistic model jointly describing flood marks at sites and flood peaks at stations. The model is based on the estimation of hidden climate indices driving both flood marks and peaks: this allows transferring information between the two variables despite them being measured on distinct networks. The model is applied to about 300 flood mark sites (1705–2015) and 200 stations (1904–2015) in France. Results demonstrate that flood marks allow estimating the time-varying probability of exceeding some high discharge threshold at stations during the whole period 1705–2015, which largely predates the existence of stations. The resulting probability maps provide quantitative information on the extent and spatial structure of ancient floods.
DOI: 10.6084/m9.figshare.24372501
title: Media consumption and COVID-19 vaccination hesitancy: health literacy as a response

description: This study explored the influence media consumption (i.e. news websites, television networks, and social media) and health literacy have on COVID-19 vaccination hesitancy. Controlling for participant political affiliation and general vaccine hesitancy, results indicated that both social media consumption and health literacy significantly predicted COVID-19 vaccine hesitancy, whereas news websites and television networks did not produce significant effects. Together, these results highlight the importance of health literacy-focused interventions, with an emphasis on social media-based content as a means of promoting COVID-19 literacy.