cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.8226938.v1
title: CURRENT PANORAMA OF ANTERIOR CRUCIATE LIGAMENT RECONSTRUCTION SURGERY IN BRAZIL

description: ABSTRACT Objective: This study aims to establish the current panorama of the anterior cruciate ligament reconstruction surgery in Brazil. Methods: A survey that consisted of a 24-item questionnaire including surgeon's demographics, preferred technique, graft selection, graft positioning, use of braces, drains, antibiotic prophylaxis and most common complications was conducted at the last three editions of a national knee surgery event. Results: Six hundred eight questionnaires were analyzed. Brazilian knee surgeons are mostly male, with mean age of 42 years (26-68) and are affiliated to at least one orthopedic society. Thirty-six percent (36%) perform more than 50 reconstructions per year. The preferred graft is the hamstring tendons graft (64%). The frequency of use of anatomical technique increased approximately from 55% from 2011 to 2013, to 85.5% in 2015 (p&lt;0.001). From 2011 to 2015, there was a progressive reduction from 56.8% to 18.1% in the frequency of use of transtibial femoral tunnel drilling (p&lt;0.001). Conclusion: Our findings show that Brazilian knee surgeons’ preferences are evolving according to the current world practice. Level of Evidence V, Economic and Decision analysis study.
DOI: 10.6084/m9.figshare.8226941.v1
title: TREATMENT OF SCHAPHOID NONUNION WITH VOLAR LOCKED PLATE

description: ABSTRACT Objective: To assess and compare radiographic, tomographic and functional pre and postoperative parameters of patients submitted to treatment of nonunion of the scaphoid waist with locked plate for scaphoid. Methods: This is a case series of scaphoid waist nonunion, operated from March 2017 to March 2018 at the Institute of Orthopedics and Traumatology of HCFMUSP, using the technique of Fisk-Fernandez and osteosynthesis with locked plate for scaphoid APTUS®Hand from Medartis. The patients were submitted to radiographs, computed tomography and functional evaluation by the occupational therapy team in the pre and postoperative periods. Results: There was consolidation of the scaphoid waist nonunion in all cases, improvement in the parameters of carpal alignment in the imaging examinations, but functionally we observed reduction of the range of motion and grip strength in relation to the contralateral limb. Conclusions: The treatment of the scaphoid waist nonunion with locked plate was effective, with a high index of consolidation and improvement of the carpal alignment in the imaging tests, although with a reduction in the range of motion and grip strength in relation to the contralateral limb when evaluated with 12 weeks postoperatively. Level of Evidence IV, Case series.
DOI: 10.6084/m9.figshare.8226926
title: Ultrasonography and magnetic resonance imaging of elbow ligaments: a comparative study

description: ABSTRACT Objective: To determine the value of ultrasonography in elbow ligament assessment compared to magnetic resonance imaging. Methods: A prospective single-center study involving 30 volunteers with no elbow joint changes. Two experienced ultrasound specialists evaluated both elbows of each volunteer, resulting in 60 evaluations per physician and totaling up 120 evaluations. Magnetic resonance images were obtained using a 3-Tesla machine and evaluated by two experienced radiologists, totaling up 120 exams. Each examiner assigned subjective, zero-to-5 scores to ligaments imaged, where zero corresponded to non-identified ligament and 5 to visualization of the entire ligament. The level of significance was set at 5%. Bland-Altman dispersions and plots were prepared for each pair of measurements obtained. Results: All ligaments were amenable to sonographic identification; scores of 4 or 5 were assigned by examiners based on ligament visibility. Ligaments could also be identified using magnetic resonance imaging and were assigned scores of 5 by examiners. All ligaments were described as intact and healthy by all four examiners. Comparative analysis of elbow ligament sonographic and magnetic resonance imaging findings did not differ significantly. Conclusion: Ultrasonography and magnetic resonance imaging can be considered equivalent modalities for elbow ligament assessment in the hands of experienced examiners.
DOI: 10.6084/m9.figshare.8226932
title: Pharmacological characterization of the calcium influx pathways involved in nitric oxide production by endothelial cells

description: ABSTRACT Objective: To characterize the calcium influx pathways implicated in the sustained elevation of endothelial intracellular calcium concentration, required for the synthesis and release of relaxing factors. Methods: We evaluated the effect of the newly synthesized pyrazole derivatives, described as selective inhibitors for ORAI (BTP2/Pyr2 and Pyr6) and TRPC3 (Pyr3 and Pyr10) channels, upon endothelium- and extracellular calcium-dependent relaxations stimulated by acetylcholine and thapsigargin, in pre-constricted rat thoracic aortic rings. Results: Acetylcholine and thapsigargin responses were completely reverted by Pyr2 and Pyr6 (1 to 3μM). Pyr3 (0.3 to 3μM) caused a rapid reversal of acetylcholine (6.2±0.08mg.s−1) and thapsigargin (3.9±0.25mg.s−1) relaxations, whereas the more selective TRPC3 blocker Pyr10 (1 to 3μM) had no effect. The recently described TRPC4/5 selective blocker, ML204 (1 to 3μM), reverted completely acetylcholine relaxations, but minimally thapsigargin induced ones. Noteworthy, relaxations elicited by GSK1016790A (TRPV4 agonist) were unaffected by pyrazole compounds or ML204. After Pyr2 and Pyr6 pre-incubation, acetylcholine and thapsigargin evoked transient relaxations similar in magnitude and kinetics to those observed in the absence of extracellular calcium. Sodium nitroprusside relaxations as well as phenylephrine-induced contractions (denuded aorta) were not affected by any of pyrazole compounds (1 to 3μM). Conclusion: These observations revealed a previously unrecognized complexity in rat aorta endothelial calcium influx pathways, which result in production and release of nitric oxide. Pharmacologically distinguishable pathways mediate acetylcholine (ORAI/TRPC other than TRPC3/TRPC4 calcium-permeable channels) and thapsigargin (TRPC4 not required) induced calcium influx.
DOI: 10.6084/m9.figshare.8226935
title: Evaluation of the Planetary Boundary Layer Parameterizations of WRF Model in North Northeast Coast at Brazil

description: Abstract This work aims to evaluate two simulations of the WRF model that differ in their parameterization of the Planetary Boundary Layer (PBL). For this goal, we have used data from 72 radiosondes launched in Fortaleza (CE) between April 5th to 25th of 2011 in the synoptic times. The PBL height was the evaluated metric and the observational data were calculated through the vertical potential temperature method, obtaining 245±28 m for nighttime and 925±63 m for daytime. The Asymmetric Convective Model V2 (ACM2) and the Mellor Yamada Nakanish and Niino 2.5 (MYNN2.5) PBL parameterizations have been evaluated. The skills of these parameterizations were evaluated by statistical comparison with observational data through Mean Absolute Error (MAE) and the refined Willmott’s index of agreement (dr). For ACM2, MAE was 282 m and 519 m and dr was 0.53 and 0.37 for the nighttime and daytime periods, respectively. In the MYNN2.5 simulation, MAE values were found between 312 and 266 m, with dr between 0.59 and 0.56 for the nighttime and daytime, respectively. At 06, 12 and 18 UTC, MYNN2.5 was better, considering both metrics. However, ACM2 presented better performance only at 00 UTC.
DOI: 10.6084/m9.figshare.8226935.v1
title: Evaluation of the Planetary Boundary Layer Parameterizations of WRF Model in North Northeast Coast at Brazil

description: Abstract This work aims to evaluate two simulations of the WRF model that differ in their parameterization of the Planetary Boundary Layer (PBL). For this goal, we have used data from 72 radiosondes launched in Fortaleza (CE) between April 5th to 25th of 2011 in the synoptic times. The PBL height was the evaluated metric and the observational data were calculated through the vertical potential temperature method, obtaining 245±28 m for nighttime and 925±63 m for daytime. The Asymmetric Convective Model V2 (ACM2) and the Mellor Yamada Nakanish and Niino 2.5 (MYNN2.5) PBL parameterizations have been evaluated. The skills of these parameterizations were evaluated by statistical comparison with observational data through Mean Absolute Error (MAE) and the refined Willmott’s index of agreement (dr). For ACM2, MAE was 282 m and 519 m and dr was 0.53 and 0.37 for the nighttime and daytime periods, respectively. In the MYNN2.5 simulation, MAE values were found between 312 and 266 m, with dr between 0.59 and 0.56 for the nighttime and daytime, respectively. At 06, 12 and 18 UTC, MYNN2.5 was better, considering both metrics. However, ACM2 presented better performance only at 00 UTC.
DOI: 10.6084/m9.figshare.8226926.v1
title: Ultrasonography and magnetic resonance imaging of elbow ligaments: a comparative study

description: ABSTRACT Objective: To determine the value of ultrasonography in elbow ligament assessment compared to magnetic resonance imaging. Methods: A prospective single-center study involving 30 volunteers with no elbow joint changes. Two experienced ultrasound specialists evaluated both elbows of each volunteer, resulting in 60 evaluations per physician and totaling up 120 evaluations. Magnetic resonance images were obtained using a 3-Tesla machine and evaluated by two experienced radiologists, totaling up 120 exams. Each examiner assigned subjective, zero-to-5 scores to ligaments imaged, where zero corresponded to non-identified ligament and 5 to visualization of the entire ligament. The level of significance was set at 5%. Bland-Altman dispersions and plots were prepared for each pair of measurements obtained. Results: All ligaments were amenable to sonographic identification; scores of 4 or 5 were assigned by examiners based on ligament visibility. Ligaments could also be identified using magnetic resonance imaging and were assigned scores of 5 by examiners. All ligaments were described as intact and healthy by all four examiners. Comparative analysis of elbow ligament sonographic and magnetic resonance imaging findings did not differ significantly. Conclusion: Ultrasonography and magnetic resonance imaging can be considered equivalent modalities for elbow ligament assessment in the hands of experienced examiners.
DOI: 10.6084/m9.figshare.8226932.v1
title: Pharmacological characterization of the calcium influx pathways involved in nitric oxide production by endothelial cells

description: ABSTRACT Objective: To characterize the calcium influx pathways implicated in the sustained elevation of endothelial intracellular calcium concentration, required for the synthesis and release of relaxing factors. Methods: We evaluated the effect of the newly synthesized pyrazole derivatives, described as selective inhibitors for ORAI (BTP2/Pyr2 and Pyr6) and TRPC3 (Pyr3 and Pyr10) channels, upon endothelium- and extracellular calcium-dependent relaxations stimulated by acetylcholine and thapsigargin, in pre-constricted rat thoracic aortic rings. Results: Acetylcholine and thapsigargin responses were completely reverted by Pyr2 and Pyr6 (1 to 3μM). Pyr3 (0.3 to 3μM) caused a rapid reversal of acetylcholine (6.2±0.08mg.s−1) and thapsigargin (3.9±0.25mg.s−1) relaxations, whereas the more selective TRPC3 blocker Pyr10 (1 to 3μM) had no effect. The recently described TRPC4/5 selective blocker, ML204 (1 to 3μM), reverted completely acetylcholine relaxations, but minimally thapsigargin induced ones. Noteworthy, relaxations elicited by GSK1016790A (TRPV4 agonist) were unaffected by pyrazole compounds or ML204. After Pyr2 and Pyr6 pre-incubation, acetylcholine and thapsigargin evoked transient relaxations similar in magnitude and kinetics to those observed in the absence of extracellular calcium. Sodium nitroprusside relaxations as well as phenylephrine-induced contractions (denuded aorta) were not affected by any of pyrazole compounds (1 to 3μM). Conclusion: These observations revealed a previously unrecognized complexity in rat aorta endothelial calcium influx pathways, which result in production and release of nitric oxide. Pharmacologically distinguishable pathways mediate acetylcholine (ORAI/TRPC other than TRPC3/TRPC4 calcium-permeable channels) and thapsigargin (TRPC4 not required) induced calcium influx.
DOI: 10.6084/m9.figshare.8226917
title: Body composition, strength static and isokinetic, and bone health: comparative study between active adults and amateur soccer players

description: ABSTRACT Objective: To compare tissue composition, total and regional bone mineral content and bone mineral density, static hand grip and knee joint isokinetic strength between amateur soccer players and Control Group. Methods: Cross-sectional study. Air displacement plethysmography was used to estimate body volume and, in turn, density. Body composition, bone mineral content and bone mineral density were assessed for the whole body and at standardized regions using dual energy X-ray absorptiometry. Static grip strength was assessed with an adjustable dynamometer, and peak torque derived from isokinetic strength dynamometer (concentric muscular knee actions at 60°/s). Magnitude of the differences between groups was examined using d-Cohen. Results: Compared to healthy active adults, soccer players showed larger values of whole body bone mineral content (+651g; d=1.60; p&lt;0.01). In addition, differences between groups were large for whole body bone mineral density (d=1.20 to 1.90; p&lt;0.01): lumbar spine, i.e. L1-L4 (+19.4%), upper limbs (+8.6%) and lower limbs (+16.8%). Soccer players attained larger mean values in strength test given by static hand grip protocol (+5.6kg, d=0.99; p&lt;0.01). Conclusion: Soccer adequately regulates body composition and is associated better bone health parameters (bone mineral content and density at whole-body and at particular sites exposed to mechanical loadings).
DOI: 10.6084/m9.figshare.8226920
title: Lipid profile and statin use in critical care setting: implications for kidney outcome

description: ABSTRACT Objective: To determine whether pre-hospital statin use is associated with lower renal replacement therapy requirement and/or death during intensive care unit stay. Methods: Prospective cohort analysis. We analyzed 670 patients consecutively admitted to the intensive care unit of an academic tertiary-care hospital. Patients with ages ranging from 18 to 80 years admitted to the intensive care unit within the last 48 hours were included in the study. Results: Mean age was 66±16.1 years old, mean body mass index 26.6±4/9kg/m2 and mean abdominal circumference was of 97±22cm. The statin group comprised 18.2% of patients and had lower renal replacement therapy requirement and/or mortality (OR: 0.41; 95%CI: 0.18-0.93; p=0.03). The statin group also had lower risk of developing sepsis during intensive care unit stay (OR: 0.42; 95%CI: 0.22-0.77; p=0.006) and had a reduction in hospital length-of-stay (14.7±17.5 days versus 22.3±48 days; p=0.006). Statin therapy was associated with a protective role in critical care setting independently of confounding variables, such as gender, age, C-reactive protein, need of mechanical ventilation, use of pressor agents and presence of diabetes and/or coronary disease. Conclusion: Statin therapy prior to hospital admission was associated with lower mortality, lower renal replacement therapy requirement and sepsis rates.
DOI: 10.6084/m9.figshare.8226923
title: What is the appropriate time to measure outcome and process factors in psychodynamic psychotherapy?

description: Abstract Introduction Different instruments and methods for measuring factors related to the progress and effectiveness of psychodynamic psychotherapy (PDT) have been widely discussed in the literature. However, there are no established guidelines on the most appropriate time to perform these measurements. Objectives The aim of this study is to problematize what is the appropriate time to measure the initial outcomes (symptoms, interpersonal relationships, quality, and social role) and process factors (alliance) in the early stages of PDT. Methods A naturalistic cohort study was conducted, following 304 patients during the first six months of psychotherapy. The therapeutic alliance was evaluated after four sessions; symptoms, interpersonal relationships, and social role were evaluated at intake and after 12 and 24 sessions. Results Our results indicate that four sessions were sufficient to measure the bond dimension of the therapeutic alliance, while more time is probably needed to adequately measure other aspects of the therapeutic alliance, such as tasks and goals. However, 12 sessions of treatment proved sufficient to detect improvements in all dimensions of the outcome instruments with moderate effect sizes, and those gains were stable at the 24th session. Conclusion According to our findings, 12 sessions seem to be sufficient to assess initial gains in PDT, although more studies are needed to evaluate the appropriate time to assess all aspects of the therapeutic alliance. Further studies are also required to evaluate the appropriate time to assess intermediate and long-term progress with regard to symptoms, interpersonal relations, social role and personality reorganization.
DOI: 10.6084/m9.figshare.8226914
title: The Nakagami Distribution Applied in Precipitation Data Analysis

description: Abstract This research had as its objective evaluating if Nakagami distribution achieves in precipitation data analysis, by considering monthly data series over several years, in an attempt to select a useful distribution that helps in the management and administration of those activities that depends on Southern Brazil precipitation index. For this purpose Nakagami distribution was compared with five alternatives: Weibull, Gamma, Log-Normal, Log-Logistic e Inverse-Gaussian. In the analysis, data series belonging to 33 weather stations between January 1970 and December 2014 were used, amounting 396 data series (33 weather × stations 12 months). In order to choose the best distribution were used the Akaike Information, the Kolmogorov-Smirnov, then Anderson-Darling and the Cramér-von Mises criterions. According to these criterions, it can be found that Nakagami and Weibull distributions were selected the greatest number of times (Nakagami: 146 times and Weibull: 100 times). Even though Nakagami distribution is not too used in rain precipitation data description, we recommend its application in the description of monthly precipitation behavior as an alternative of distributions that have been traditionally applied.
DOI: 10.6084/m9.figshare.8226923.v1
title: What is the appropriate time to measure outcome and process factors in psychodynamic psychotherapy?

description: Abstract Introduction Different instruments and methods for measuring factors related to the progress and effectiveness of psychodynamic psychotherapy (PDT) have been widely discussed in the literature. However, there are no established guidelines on the most appropriate time to perform these measurements. Objectives The aim of this study is to problematize what is the appropriate time to measure the initial outcomes (symptoms, interpersonal relationships, quality, and social role) and process factors (alliance) in the early stages of PDT. Methods A naturalistic cohort study was conducted, following 304 patients during the first six months of psychotherapy. The therapeutic alliance was evaluated after four sessions; symptoms, interpersonal relationships, and social role were evaluated at intake and after 12 and 24 sessions. Results Our results indicate that four sessions were sufficient to measure the bond dimension of the therapeutic alliance, while more time is probably needed to adequately measure other aspects of the therapeutic alliance, such as tasks and goals. However, 12 sessions of treatment proved sufficient to detect improvements in all dimensions of the outcome instruments with moderate effect sizes, and those gains were stable at the 24th session. Conclusion According to our findings, 12 sessions seem to be sufficient to assess initial gains in PDT, although more studies are needed to evaluate the appropriate time to assess all aspects of the therapeutic alliance. Further studies are also required to evaluate the appropriate time to assess intermediate and long-term progress with regard to symptoms, interpersonal relations, social role and personality reorganization.
DOI: 10.6084/m9.figshare.8226911
title: Analysis of asset pricing models under an epistemic approach of positivism/post-positivism and constructivism

description: Abstract This article aimed to conduct an epistemological evaluation of research methods in finance by means of an analysis of asset pricing models under the philosophical currents of positivism/post-positivism and constructivism. Thus, we explain the adequacy of these models to society, understanding that the phenomena under study are not repetitive, but subject to analysis. We show evidence that the asset pricing models have methodological characteristics that fit both positivism and post-positivism, as well as constructivism, considering the possibility to misrepresent the hypotheses and their adequacy to investor's subjectivities. The results obtained in this theoretical survey suggest that classical finance and their subsequent behavioral contributions highlight positivist methods subject to misrepresentation of hypotheses and, as a consequence, a science under construction, demonstrating the complementarity between the epistemological views presented.
DOI: 10.6084/m9.figshare.8226917.v1
title: Body composition, strength static and isokinetic, and bone health: comparative study between active adults and amateur soccer players

description: ABSTRACT Objective: To compare tissue composition, total and regional bone mineral content and bone mineral density, static hand grip and knee joint isokinetic strength between amateur soccer players and Control Group. Methods: Cross-sectional study. Air displacement plethysmography was used to estimate body volume and, in turn, density. Body composition, bone mineral content and bone mineral density were assessed for the whole body and at standardized regions using dual energy X-ray absorptiometry. Static grip strength was assessed with an adjustable dynamometer, and peak torque derived from isokinetic strength dynamometer (concentric muscular knee actions at 60°/s). Magnitude of the differences between groups was examined using d-Cohen. Results: Compared to healthy active adults, soccer players showed larger values of whole body bone mineral content (+651g; d=1.60; p&lt;0.01). In addition, differences between groups were large for whole body bone mineral density (d=1.20 to 1.90; p&lt;0.01): lumbar spine, i.e. L1-L4 (+19.4%), upper limbs (+8.6%) and lower limbs (+16.8%). Soccer players attained larger mean values in strength test given by static hand grip protocol (+5.6kg, d=0.99; p&lt;0.01). Conclusion: Soccer adequately regulates body composition and is associated better bone health parameters (bone mineral content and density at whole-body and at particular sites exposed to mechanical loadings).