cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.13130/rd_unimi/pddrps/ysnpci
title: Febbraio_1937_Pagina_175.jpg

description: Bulletin of 1937/02/18
DOI: 10.13130/rd_unimi/cgo8lw/rmujzp
title: Luglio_1914_Pagina_138.jpg

description: Bulletin of 1914/07/23
DOI: 10.13130/rd_unimi/zbysir/aezc92
title: Ottobre_1900_Pagina_040.jpg

description: Bulletin of 1900/10/10
DOI: 10.13130/rd_unimi/zvkzj5/kj3lq5
title: Luglio_1918_Pagina_124.jpg

description: Bulletin of 1918/07/21
DOI: 10.13130/rd_unimi/cmir61/844gyf
title: Ottobre_1897_Pagina_114.jpg

description: Bulletin of 1897/10/29
DOI: 10.13130/rd_unimi/i5awbn/c6tbho
title: Luglio_1920_Pagina_112.jpg

description: Bulletin of 1920/07/19
DOI: 10.13130/rd_unimi/pddrps/wlym57
title: Febbraio_1937_Pagina_176.jpg

description: Bulletin of 1937/02/18
DOI: 10.13130/rd_unimi/cea2oy/gt1jel
title: Settembre_1888_Pagina_006.jpg

description: Bulletin of 1888/09/02
DOI: 10.13130/rd_unimi/zbysir/imz9q7
title: Ottobre_1900_Pagina_041.jpg

description: Bulletin of 1900/10/11
DOI: 10.13130/rd_unimi/zvkzj5/pwncak
title: Luglio_1918_Pagina_125.jpg

description: Bulletin of 1918/07/21
DOI: 10.13130/rd_unimi/cgo8lw/5slwmz
title: Luglio_1914_Pagina_139.jpg

description: Bulletin of 1914/07/24
DOI: 10.13130/rd_unimi/i5awbn/hl0uts
title: Luglio_1920_Pagina_113.jpg

description: Bulletin of 1920/07/19
DOI: 10.13130/rd_unimi/cea2oy/rsa60d
title: Settembre_1888_Pagina_007.jpg

description: Bulletin of 1888/09/02
DOI: 10.13130/rd_unimi/cmir61/oj3kx2
title: Ottobre_1897_Pagina_115.jpg

description: Bulletin of 1897/10/29
DOI: 10.13130/rd_unimi/pddrps/rkunzb
title: Febbraio_1937_Pagina_177.jpg

description: Bulletin of 1937/02/18
DOI: 10.13130/rd_unimi/cgo8lw/bfeyh4
title: Luglio_1914_Pagina_140.jpg

description: Bulletin of 1914/07/24
DOI: 10.13130/rd_unimi/i5awbn/8gkjyo
title: Luglio_1920_Pagina_114.jpg

description: Bulletin of 1920/07/19
DOI: 10.13130/rd_unimi/zbysir/nuvqvr
title: Ottobre_1900_Pagina_042.jpg

description: Bulletin of 1900/10/11
DOI: 10.13130/rd_unimi/zvkzj5/geyof3
title: Luglio_1918_Pagina_126.jpg

description: Bulletin of 1918/07/21
DOI: 10.17632/rn23vbrfhb
title: Small-molecule inhibitor of C‑terminal HSP90 dimerization modulates autophagy and functions synergistically with mTOR inhibition to kill cisplatin-resistant cancer cells

description: A major obstacle for the successful treatment of cancer is the presence or development of resistance mechanisms toward therapeutic intervention. In urothelial cancer, cisplatin-based regimens are still routinely employed, and multiple pathways contribute to chemoresistance. Since the identification of heat shock protein 90 (HSP90) as potential cancer target, various HSP90 inhibitors have been developed and evaluated in clinical trials. However, limited efficacy has been observed, mainly caused by dose-limiting toxicity and the concomitant induction of a cytoprotective heat shock response (HSR). To avoid this effect, inhibitors targeting the C-terminal domain (CTD) of HSP90 that do not elicit an HSR have been put forward. Additionally, the crosstalk between autophagy and HSP90 is currently being explored, since both processes work together in proteostasis, and the modulation of autophagy might be helpful in order to improve the efficacy of HSP90 inhibitors. We demonstrate that the second-generation small-molecule inhibitor VWK147 targeting HSP90 CTD dimerization induces cell death in both cisplatin-sensitive and cisplatin-resistant urothelial carcinoma cells. The treatment with VWK147 in these cells led to the destabilization of classical HSP90 client proteins without triggering an HSR. Additionally, we observe that VWK147 re-sensitizes resistant urothelial carcinoma cells to cisplatin and—in combination with mTOR inhibition—synergistically kills cisplatin-sensitive and -resistant cells, in contrast to what is observed upon treatment with the N-terminal domain-targeting HSP90 inhibitor 17-AAG. This synergy may be explained by VWK147-mediated inhibition of late autophagy events, and thus a blockade of autophagic flux. Finally, we also observed that VWK147 induces non-canonical LC3 lipidation, indicating that this compound exerts a broader effect on ion balance or pH of the endolysosomal system. VWK147 is a promising inhibitor that targets the C-terminal dimerization of HSP90 and simultaneously exhibits autophagy-modulating effects. This compound could potentially be an effective option for improving anti-cancer therapies and/or overcoming treatment resistance.
DOI: 10.13130/rd_unimi/pddrps/ciilxv
title: Febbraio_1937_Pagina_178.jpg

description: Bulletin of 1937/02/18
DOI: 10.13130/rd_unimi/zvkzj5/hsqjif
title: Luglio_1918_Pagina_127.jpg

description: Bulletin of 1918/07/22
DOI: 10.13130/rd_unimi/cea2oy/vfkafz
title: Settembre_1888_Pagina_008.jpg

description: Bulletin of 1888/09/02
DOI: 10.13130/rd_unimi/cgo8lw/9kjuqu
title: Luglio_1914_Pagina_141.jpg

description: Bulletin of 1914/07/24
DOI: 10.13130/rd_unimi/cmir61/urkb6b
title: Ottobre_1897_Pagina_116.jpg

description: Bulletin of 1897/10/29
DOI: 10.13130/rd_unimi/zbysir/rolhgl
title: Ottobre_1900_Pagina_043.jpg

description: Bulletin of 1900/10/11
DOI: 10.17632/rn23vbrfhb.1
title: Small-molecule inhibitor of C‑terminal HSP90 dimerization modulates autophagy and functions synergistically with mTOR inhibition to kill cisplatin-resistant cancer cells

description: A major obstacle for the successful treatment of cancer is the presence or development of resistance mechanisms toward therapeutic intervention. In urothelial cancer, cisplatin-based regimens are still routinely employed, and multiple pathways contribute to chemoresistance. Since the identification of heat shock protein 90 (HSP90) as potential cancer target, various HSP90 inhibitors have been developed and evaluated in clinical trials. However, limited efficacy has been observed, mainly caused by dose-limiting toxicity and the concomitant induction of a cytoprotective heat shock response (HSR). To avoid this effect, inhibitors targeting the C-terminal domain (CTD) of HSP90 that do not elicit an HSR have been put forward. Additionally, the crosstalk between autophagy and HSP90 is currently being explored, since both processes work together in proteostasis, and the modulation of autophagy might be helpful in order to improve the efficacy of HSP90 inhibitors. We demonstrate that the second-generation small-molecule inhibitor VWK147 targeting HSP90 CTD dimerization induces cell death in both cisplatin-sensitive and cisplatin-resistant urothelial carcinoma cells. The treatment with VWK147 in these cells led to the destabilization of classical HSP90 client proteins without triggering an HSR. Additionally, we observe that VWK147 re-sensitizes resistant urothelial carcinoma cells to cisplatin and—in combination with mTOR inhibition—synergistically kills cisplatin-sensitive and -resistant cells, in contrast to what is observed upon treatment with the N-terminal domain-targeting HSP90 inhibitor 17-AAG. This synergy may be explained by VWK147-mediated inhibition of late autophagy events, and thus a blockade of autophagic flux. Finally, we also observed that VWK147 induces non-canonical LC3 lipidation, indicating that this compound exerts a broader effect on ion balance or pH of the endolysosomal system. VWK147 is a promising inhibitor that targets the C-terminal dimerization of HSP90 and simultaneously exhibits autophagy-modulating effects. This compound could potentially be an effective option for improving anti-cancer therapies and/or overcoming treatment resistance.
DOI: 10.13130/rd_unimi/i5awbn/prmz0e
title: Luglio_1920_Pagina_115.jpg

description: Bulletin of 1920/07/20
DOI: 10.13130/rd_unimi/pddrps/ablcqq
title: Febbraio_1937_Pagina_179.jpg

description: Bulletin of 1937/02/18
DOI: 10.13130/rd_unimi/cea2oy/slhrfi
title: Settembre_1888_Pagina_009.jpg

description: Bulletin of 1888/09/03
DOI: 10.13130/rd_unimi/cmir61/hnc99j
title: Ottobre_1897_Pagina_117.jpg

description: Bulletin of 1897/10/30
DOI: 10.13130/rd_unimi/cgo8lw/vxmzdf
title: Luglio_1914_Pagina_142.jpg

description: Bulletin of 1914/07/24
DOI: 10.13130/rd_unimi/i5awbn/9uootp
title: Luglio_1920_Pagina_116.jpg

description: Bulletin of 1920/07/20
DOI: 10.13130/rd_unimi/zbysir/pynovm
title: Ottobre_1900_Pagina_044.jpg

description: Bulletin of 1900/10/11
DOI: 10.13130/rd_unimi/zvkzj5/jhyd7u
title: Luglio_1918_Pagina_128.jpg

description: Bulletin of 1918/07/22
DOI: 10.13130/rd_unimi/cea2oy/wcg5aj
title: Settembre_1888_Pagina_010.jpg

description: Bulletin of 1888/09/03
DOI: 10.13130/rd_unimi/cmir61/errlsd
title: Ottobre_1897_Pagina_118.jpg

description: Bulletin of 1897/10/30
DOI: 10.13130/rd_unimi/pddrps/atb3vu
title: Febbraio_1937_Pagina_180.jpg

description: Bulletin of 1937/02/18
DOI: 10.13130/rd_unimi/cgo8lw/ygnuhg
title: Luglio_1914_Pagina_143.jpg

description: Bulletin of 1914/07/24
DOI: 10.13130/rd_unimi/zvkzj5/oiaqdb
title: Luglio_1918_Pagina_129.jpg

description: Bulletin of 1918/07/22
DOI: 10.13130/rd_unimi/i5awbn/1oizgi
title: Luglio_1920_Pagina_117.jpg

description: Bulletin of 1920/07/20
DOI: 10.13130/rd_unimi/pddrps/kqxh72
title: Febbraio_1937_Pagina_181.jpg

description: Bulletin of 1937/02/19
DOI: 10.13130/rd_unimi/cea2oy/ipjnll
title: Settembre_1888_Pagina_011.jpg

description: Bulletin of 1888/09/03
DOI: 10.13130/rd_unimi/cmir61/ijgm85
title: Ottobre_1897_Pagina_119.jpg

description: Bulletin of 1897/10/30
DOI: 10.13130/rd_unimi/zbysir/cc8hnd
title: Ottobre_1900_Pagina_045.jpg

description: Bulletin of 1900/10/12
DOI: 10.13130/rd_unimi/cgo8lw/j1wiuc
title: Luglio_1914_Pagina_144.jpg

description: Bulletin of 1914/07/24
DOI: 10.13130/rd_unimi/zvkzj5/y5nz6i
title: Luglio_1918_Pagina_130.jpg

description: Bulletin of 1918/07/22
DOI: 10.13130/rd_unimi/cmir61/pwlv7d
title: Ottobre_1897_Pagina_120.jpg

description: Bulletin of 1897/10/30
DOI: 10.13130/rd_unimi/i5awbn/rb8paj
title: Luglio_1920_Pagina_118.jpg

description: Bulletin of 1920/07/20
DOI: 10.13130/rd_unimi/pddrps/ldfr7a
title: Febbraio_1937_Pagina_182.jpg

description: Bulletin of 1937/02/19
DOI: 10.13130/rd_unimi/zbysir/vhbxbl
title: Ottobre_1900_Pagina_046.jpg

description: Bulletin of 1900/10/12
DOI: 10.11587/5xwpkk
title: Pre and Post Election Panel Study on Issue Yield and Voters' Priorities in the 2017 Austrian Elections (SUF edition)

description: Full edition for scientific use. The dataset includes a pre and post election panel study conducted in Austria to investigate positional and valence political issues that have characterized the 2017 Austrian election campaign. The dataset includes of a pre-electoral wave conducted in September 2017 and a post-electoral wave conducted after the elections in October and November 2017. Both survey waves were carried out using Computer-assisted web interviewing (CAWI) interviewing Austrian citizens.
description: AUTNES
description: This project is part of ICCP - The Issue Competition Comparative Project 2017-2018 Round. 
<br>
Find out more about the Issue Competition Comparative Project here: De Sio, L., Emanuele, V., Maggini, N., Paparo, A., Angelucci, D., & D´Alimonte, R. (2019): Issue Competition Comparative Project (ICCP). GESIS Data Archive, Cologne. ZA7499 Data file Version 1.0.0, doi:10.4232/1.13328.
DOI: 10.13130/rd_unimi/cea2oy/dqw2e7
title: Settembre_1888_Pagina_012.jpg

description: Bulletin of 1888/09/03
DOI: 10.13130/rd_unimi/cgo8lw/cymv8i
title: Luglio_1914_Pagina_145.jpg

description: Bulletin of 1914/07/25
DOI: 10.11587/imkdzi
title: AUTNES Comparative Study of Electoral Systems Post-Election Survey 2017 (SUF edition)

description: Full edition for scientific use. The survey is based on the Comparative Study of Electoral Systems (CSES) Module 5 and focuses on the Austrian National Parliamentary Election held on 15 October 2017. This survey is part of the Austrian National Election Study (AUTNES).
description: AUTNES
DOI: 10.11587/w193uz
title: AUTNES Comparative Study of Electoral Systems Post-Election Survey 2017 (CSES Edition, OA edition)

description: Reduced edition for public use. Full edition available for scientific use. This is Open Access data based on the Comparative Study of Electoral Systems (CSES) Module 5 and focuses on the Austrian National Parliamentary Election held on 15 October 2017. This survey is part of the Austrian National Election Study (AUTNES).

You can find the CSES cross country data set and the english questionnaire for module 5 on the CSES Website.
description: AUTNES
DOI: 10.13130/rd_unimi/cmir61/i1tjwo
title: Ottobre_1897_Pagina_121.jpg

description: Bulletin of 1897/10/31
DOI: 10.13130/rd_unimi/i5awbn/7bcyhy
title: Luglio_1920_Pagina_119.jpg

description: Bulletin of 1920/07/20
DOI: 10.13130/rd_unimi/zbysir/adb4df
title: Ottobre_1900_Pagina_047.jpg

description: Bulletin of 1900/10/12
DOI: 10.11587/i7qiyj
title: AUTNES Online Panel Study 2017 (SUF edition)

description: Full edition for scientific use. The AUTNES Online Panel Study 2017 is a six-wave panel that focuses on the Austrian National Parliamentary Election held on 15 October 2017. This survey is part of the Austrian National Election Study (AUTNES).
description: AUTNES
DOI: 10.11587/jf64yw
title: AUTNES Candidate Survey 2008 (SUF edition)

description: Full edition for scientific use. The AUTNES Candidate Survey 2008 was conducted after the Austrian national parliamentary election of 28 September 2008. The dataset is based on a written census survey of the 4081 candidates for the National Council election. Candidates were asked questions on four topics: Political background and activities, campaigning, issues and policies as well as democracy and representation. The first subject area contains variables like the candidates’ party affiliation, its duration and possible changes as well as several indicators for political activity like association membership or the average weekly time spent with party activities. Next, candidates were asked about several details of their campaign: Its aim and strategy, time spent, occurring problems, communication means, personal campaign funds and relationship with the party. The third section on issues and policies also includes (besides questions about the candidates’ positions on several topics) coalition preferences, left–right self-placement and opinions on EU topics. The final part of the dataset holds information on candidates’ general attitudes about democracy, their preferred electoral system as well as their understanding of how a Member of Parliament should act.
description: AUTNES
DOI: 10.13130/rd_unimi/pddrps/gtmzof
title: Febbraio_1937_Pagina_183.jpg

description: Bulletin of 1937/02/19
DOI: 10.13130/rd_unimi/zvkzj5/ae2nkh
title: Luglio_1918_Pagina_131.jpg

description: Bulletin of 1918/07/22
DOI: 10.11587/gdbbpj
title: AUTNES Comparative Study of Electoral Systems Post-Election Survey 2017 (AUTNES Edition, OA edition)

description: Reduced edition for public use. Full edition available for scientific use. This is Open Access data based on the Comparative Study of Electoral Systems (CSES) Module 5 and focuses on the Austrian National Parliamentary Election held on 15 October 2017. This survey is part of the Austrian National Election Study (AUTNES).
description: AUTNES
DOI: 10.11587/nxddpe
title: AUTNES Multi-Mode Panel Study 2017 (SUF edition)

description: Full edition for scientific use. The AUTNES Multi-Mode Panel Study 2017 is a three-wave panel that focuses on the Austrian National Parliamentary Election held on 15 October 2017. This survey is part of the Austrian National Election Study (AUTNES).
description: AUTNES
DOI: 10.11587/qzg1xh
title: AUTNES Post Post Election Survey 2009 (SUF edition)

description: Full edition for scientific use. This dataset contains political preferences of Austrian citizens eligible to vote (age 18 and older) after the national parliamentary election on 28.9.2008. It was conducted in the period 6.5. – 2.7.2009 through personal interviews (CAPI). 1165 respondents were selected via multilevel stratified probability sampling. The Kish selection method was used to reach younger respondents.

Important variables are, among others, participation in the election; party preferences and party identification; media usage; ways of seeking political information; party closeness; self- and party-placements on a left-right scale; political participation; interest in the electoral campaign; coalition preferences; institutional trust; and preferences concerning the EU and other topical issues such as migration and asylum, the financial crisis, the environment, and nuclear energy. Additional variables capture demographics, weights, and interview ratings.
description: AUTNES
DOI: 10.13130/rd_unimi/cea2oy/yamd5i
title: Settembre_1888_Pagina_013.jpg

description: Bulletin of 1888/09/04
DOI: 10.13130/rd_unimi/cgo8lw/tgpnr1
title: Luglio_1914_Pagina_146.jpg

description: Bulletin of 1914/07/25
DOI: 10.13130/rd_unimi/zbysir/8iazic
title: Ottobre_1900_Pagina_048.jpg

description: Bulletin of 1900/10/12
DOI: 10.11587/2effly
title: AUTNES Rolling-Cross-Section Panel Study 2013 (SUF edition)

description: Full edition for scientific use. This dataset contains political preferences of Austrian citizens eligible to vote (age 16 and older) before (wave 1) and after (waves 2 and 3) the national parliamentary election on 29.9.2013. Telephone interviews (CATI) were conducted in the periods 5.8. – 27.9.2013 (wave 1), 1.10. – 4.11.2013 (wave 2) and 14.8. – 20.10.2015 (wave 3). The first wave is based on a rolling-cross-section design. For wave 1, 4011 respondents were randomly sampled and re-interviewed in wave 2 (n = 2607) and wave 3 (n = 1223).

Important variables are, among others, the most important political issues concerning the upcoming national electoral campaign and which party is most qualified to deal with them; party closeness and party identification; self- and party-placements on a left-right scale; a like-dislike-scale for parties and selected front-running politicians; probability of participating in the election and vote choice; contact with politicians and parties; coalition preferences; media usage and ways of seeking political information; and preferences on issues such as the financial and euro crisis, school, combating unemployment and corruption, immigration policy, and housing. Additional variables capture demographics, weights, and interview ratings.
description: AUTNES
DOI: 10.11587/5zo48v
title: AUTNES Comparative Study of Electoral Systems Post-Election Survey 2013 (SUF edition)

description: Full edition for scientific use. This dataset contains political preferences of Austrian citizens eligible to vote (age 16 and older) after the national parliamentary election on 29.9.2013. Telephone interviews (CATI) were conducted in the period 1.10. – 29.10.2013. 1000 respondents were selected based on proportionally stratified probability sampling. This survey is part of the international Comparative Study of Electoral Systems.

Important variables are, among others, participation in the election and vote choice; preferences concerning raising/cutting public expenditure in certain policy areas; party closeness; party preferences and party identification; satisfaction with democracy; self- and party-placements on a left-right scale; political participation; perception of campaign ads; and political knowledge. Additional variables capture demographics, weights, and interview ratings.
description: AUTNES
DOI: 10.13130/rd_unimi/cmir61/awzdul
title: Ottobre_1897_Pagina_122.jpg

description: Bulletin of 1897/10/31
DOI: 10.13130/rd_unimi/i5awbn/gx1sbs
title: Luglio_1920_Pagina_120.jpg

description: Bulletin of 1920/07/20
DOI: 10.13130/rd_unimi/pddrps/b1egph
title: Febbraio_1937_Pagina_184.jpg

description: Bulletin of 1937/02/19
DOI: 10.13130/rd_unimi/zvkzj5/oxrpjq
title: Luglio_1918_Pagina_132.jpg

description: Bulletin of 1918/07/22
DOI: 10.11587/f3drng
title: AUTNES TV Debates Panel Study 2013 (SUF edition)

description: Full edition for scientific use. This dataset contains political preferences of Austrian citizens eligible to vote at the national parliamentary election on 29.9.2013 (age 16 and older). Participants were surveyed in the period 16.8. – 7.10.2013 through an interactive online questionnaire (CAWI). Three waves were conducted before the election; a fourth wave captures opinions after the election. For the first wave, 3084 respondents were selected from a pre-existing online panel based on a quota sample. This survey emphasizes the TV debates during the election campaign and the evaluation of candidates.

Further important variables are political interest; interest in the electoral campaign; party closeness; party preferences; party identification; media consumption; usage of social networks; economic situation; attitudes towards immigrants; psychological self-characterization (Big 5); coalition preferences; satisfaction with democracy; and implicit associations towards the FPÖ. Additional variables capture demographics and technical information.
description: AUTNES
DOI: 10.11587/lbahiz
title: AUTNES Pre- and Post Panel Study 2013 (SUF edition)

description: Full edition for scientific use. This dataset contains political preferences of Austrian citizens eligible to vote at the national parliamentary election on 29.9.2013 (age 16 and older). The pre-election survey was conducted in the period 5.11.2012 – 30.6.2013 through personal interviews (CAPI); people were then re-interviewed after the election in the period 30.9. – 2.12.2013 by telephone (CATI). 3266 respondents were selected based on a proportionally stratified probability sample, and 1504 respondents were re-interviewed after the election.

Important variables are, among others, political interest; the most important political issues concerning the upcoming national electoral campaign and which party is most qualified to deal with them; party closeness; party preferences; party identification; self- and party-placements on a left-right scale; evaluation of candidates; campaign perception; media consumption; political knowledge; and preferences concerning the EU and other issues such as migration and asylum, the financial crisis, the environment, or nuclear energy. Additional variables capture demographics, weights, and interview ratings.
description: AUTNES
DOI: 10.13130/rd_unimi/cea2oy/nsag2y
title: Settembre_1888_Pagina_014.jpg

description: Bulletin of 1888/09/04
DOI: 10.13130/rd_unimi/cgo8lw/qfm5g7
title: Luglio_1914_Pagina_147.jpg

description: Bulletin of 1914/07/25
DOI: 10.13130/rd_unimi/zbysir/dir7kg
title: Ottobre_1900_Pagina_049.jpg

description: Bulletin of 1900/10/13