cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.5816448
title: Munchausen syndrome and Munchausen syndrome by proxy: a narrative review

description: ABSTRACT The Munchausen syndrome and Munchausen syndrome by proxy are factitious disorders characterized by fabrication or induction of signs or symptoms of a disease, as well as alteration of laboratory tests. People with this syndrome pretend that they are sick and tend to seek treatment, without secondary gains, at different care facilities. Both syndromes are well-recognized conditions described in the literature since 1951. They are frequently observed by health teams in clinics, hospital wards and emergency rooms. We performed a narrative, nonsystematic review of the literature, including case reports, case series, and review articles indexed in MEDLINE/PubMed from 1951 to 2015. Each study was reviewed by two psychiatry specialists, who selected, by consensus, the studies to be included in the review. Although Munchausen syndrome was first described more than 60 years ago, most of studies in the literature about it are case reports and literature reviews. Literature lacks more consistent studies about this syndrome epidemiology, therapeutic management and prognosis. Undoubtedly, these conditions generate high costs and unnecessary procedures in health care facilities, and their underdiagnose might be for lack of health professional's knowledge about them, and to the high incidence of countertransference to these patients and to others, who are exposed to high morbidity and mortality, is due to symptoms imposed on self or on others.
DOI: 10.6084/m9.figshare.5816448.v1
title: Munchausen syndrome and Munchausen syndrome by proxy: a narrative review

description: ABSTRACT The Munchausen syndrome and Munchausen syndrome by proxy are factitious disorders characterized by fabrication or induction of signs or symptoms of a disease, as well as alteration of laboratory tests. People with this syndrome pretend that they are sick and tend to seek treatment, without secondary gains, at different care facilities. Both syndromes are well-recognized conditions described in the literature since 1951. They are frequently observed by health teams in clinics, hospital wards and emergency rooms. We performed a narrative, nonsystematic review of the literature, including case reports, case series, and review articles indexed in MEDLINE/PubMed from 1951 to 2015. Each study was reviewed by two psychiatry specialists, who selected, by consensus, the studies to be included in the review. Although Munchausen syndrome was first described more than 60 years ago, most of studies in the literature about it are case reports and literature reviews. Literature lacks more consistent studies about this syndrome epidemiology, therapeutic management and prognosis. Undoubtedly, these conditions generate high costs and unnecessary procedures in health care facilities, and their underdiagnose might be for lack of health professional's knowledge about them, and to the high incidence of countertransference to these patients and to others, who are exposed to high morbidity and mortality, is due to symptoms imposed on self or on others.
DOI: 10.6084/m9.figshare.5816445
title: The limitations of ir theory regarding the environment: lessons from the anthropocene

description: Abstract Despite its relevance in the global arena, the environment does not receive the attention that it deserves within the discipline of International Relations (IR). An analysis of all of the articles published in 20 journals of relevance in IR between 2004 and 2014 supports that environmental issues have largely been disregarded. This article traces IR’s distant attitude towards the environment to its conventional disciplinary structures, arguing that the planet’s new conditions challenge the discipline’s dominant theory. It is suggested that, by rewriting itself and embracing the Anthropocene concept, IR may enhance its relevance and strengthen its impact. Recognizing uncertainty, abandoning the nature-society dichotomy and adopting a post-anthropocentric perspective are some of the possible pathways presented for the future of IR.
DOI: 10.6084/m9.figshare.5816445.v1
title: The limitations of ir theory regarding the environment: lessons from the anthropocene

description: Abstract Despite its relevance in the global arena, the environment does not receive the attention that it deserves within the discipline of International Relations (IR). An analysis of all of the articles published in 20 journals of relevance in IR between 2004 and 2014 supports that environmental issues have largely been disregarded. This article traces IR’s distant attitude towards the environment to its conventional disciplinary structures, arguing that the planet’s new conditions challenge the discipline’s dominant theory. It is suggested that, by rewriting itself and embracing the Anthropocene concept, IR may enhance its relevance and strengthen its impact. Recognizing uncertainty, abandoning the nature-society dichotomy and adopting a post-anthropocentric perspective are some of the possible pathways presented for the future of IR.
DOI: 10.6084/m9.figshare.5816442
title: Metabolites from endophytic Aspergillus fumigatus and their in vitro effect against the causal agent of tuberculosis

description: ABSTRACT Tuberculosis (TB) remains one of the most deadly communicable infectious diseases, causing 1.4 million deaths in 2015 worldwide due to many conditions, including the inadequate treatment and the emergence of multidrug-resistant strains of the causal agent, Mycobacterium tuberculosis. Therefore, drugs developed from natural sources, as microorganisms and plant extracts, are a frequent target for the research and discovery of antimicrobial compounds. The current study started the characterization of compounds produced by an Aspergillus fumigatus isolated from copaíba (Copaifera multijuga) that efficiently inhibits M. tuberculosis by releasing the compounds into the fermentation broth under specific culture conditions. A preliminary assay was carried out with a correlate species, M. smegmatis, aiming to detect an antimicrobial effect related to A. fumigatus fermentation broth. The direct use of this substrate in antibiosis assays againstM. tuberculosis H37Rv strain (ATCC 27294) allowed the detection of antimicrobial activity with a minimal inhibitory concentration of 256 μg mL-1, demonstrating that purification processes developed by the Biotage Flash Chromatography System are robust and reliable techniques for purification of compounds from natural sources. Also, this chromatographic system can be used in combination with specific biochemical tests, improving the search for reliable results. We conclude that this fraction can express a broad action range, inhibiting both Mycobacterium species used as target organisms.
DOI: 10.6084/m9.figshare.5816442.v1
title: Metabolites from endophytic Aspergillus fumigatus and their in vitro effect against the causal agent of tuberculosis

description: ABSTRACT Tuberculosis (TB) remains one of the most deadly communicable infectious diseases, causing 1.4 million deaths in 2015 worldwide due to many conditions, including the inadequate treatment and the emergence of multidrug-resistant strains of the causal agent, Mycobacterium tuberculosis. Therefore, drugs developed from natural sources, as microorganisms and plant extracts, are a frequent target for the research and discovery of antimicrobial compounds. The current study started the characterization of compounds produced by an Aspergillus fumigatus isolated from copaíba (Copaifera multijuga) that efficiently inhibits M. tuberculosis by releasing the compounds into the fermentation broth under specific culture conditions. A preliminary assay was carried out with a correlate species, M. smegmatis, aiming to detect an antimicrobial effect related to A. fumigatus fermentation broth. The direct use of this substrate in antibiosis assays againstM. tuberculosis H37Rv strain (ATCC 27294) allowed the detection of antimicrobial activity with a minimal inhibitory concentration of 256 μg mL-1, demonstrating that purification processes developed by the Biotage Flash Chromatography System are robust and reliable techniques for purification of compounds from natural sources. Also, this chromatographic system can be used in combination with specific biochemical tests, improving the search for reliable results. We conclude that this fraction can express a broad action range, inhibiting both Mycobacterium species used as target organisms.
DOI: 10.6084/m9.figshare.5816436
title: Soil Microbial Community Structure and Diversity in Cut Flower Cultures Under Conventional and Ecological Management

description: ABSTRACT Microorganisms are excellent soil quality indicators because their properties within the soil community change quickly in response to changes in the surrounding environment. The aim of this study was to determine if the structure and diversity of soil bacterial and fungal communities were useful for discriminating cut flower cultures under conventional (CM), ecological (EM), and intermediate (IM) management practices. Results obtained by PCR-DGGE revealed that bacteria had lower similarity in structure and higher diversity under EM than under CM. Sites under IM showed greater similarities in structure and diversity to the site under CM, although there were still significant differences between them. Fungal structure showed higher similarity among sites, with differences in diversity only between EM and CM. In the sites studied, bacteria, rather than fungi, were good indicators of changes in soil quality. The results of this study confirmed that EM and IM promote soil bacteria diversity.
DOI: 10.6084/m9.figshare.5816436.v1
title: Soil Microbial Community Structure and Diversity in Cut Flower Cultures Under Conventional and Ecological Management

description: ABSTRACT Microorganisms are excellent soil quality indicators because their properties within the soil community change quickly in response to changes in the surrounding environment. The aim of this study was to determine if the structure and diversity of soil bacterial and fungal communities were useful for discriminating cut flower cultures under conventional (CM), ecological (EM), and intermediate (IM) management practices. Results obtained by PCR-DGGE revealed that bacteria had lower similarity in structure and higher diversity under EM than under CM. Sites under IM showed greater similarities in structure and diversity to the site under CM, although there were still significant differences between them. Fungal structure showed higher similarity among sites, with differences in diversity only between EM and CM. In the sites studied, bacteria, rather than fungi, were good indicators of changes in soil quality. The results of this study confirmed that EM and IM promote soil bacteria diversity.
DOI: 10.6084/m9.figshare.5816433
title: A Brazilian-Portuguese version of the Kinesthetic and Visual Motor Imagery Questionnaire

description: ABSTRACT Motor imagery has emerged as a potential rehabilitation tool in stroke. The goals of this study were: 1) to develop a translated and culturally-adapted Brazilian-Portugese version of the Kinesthetic and Visual Motor Imagery Questionnaire (KVIQ20-P); 2) to evaluate the psychometric characteristics of the scale in a group of patients with stroke and in an age-matched control group; 3) to compare the KVIQ20 performance between the two groups. Methods Test-retest, inter-rater reliabilities, and internal consistencies were evaluated in 40 patients with stroke and 31 healthy participants. Results In the stroke group, ICC confidence intervals showed excellent test-retest and inter-rater reliabilities. Cronbach’s alpha also indicated excellent internal consistency. Results for controls were comparable to those obtained in persons with stroke. Conclusions The excellent psychometric properties of the KVIQ20-P should be considered during the design of studies of motor imagery interventions for stroke rehabilitation.
DOI: 10.6084/m9.figshare.5816427
title: Soil CO2 Efflux Measurements by Alkali Absorption and Infrared Gas Analyzer in the Brazilian Semiarid Region

description: ABSTRACT The CO2 emission from the soil surface, commonly referred to as soil CO2 efflux (ECO2) or soil respiration, is the sum of processes that include root respiration and microbial activity. Measuring this evolution is important to establish sustainable land use models and to estimate global fluxes of carbon, which affect climate change. Despite its importance, few measurements have been made in areas of the semiarid Brazilian Northeast region, and most of them were made using the alkali absorption method (AA), which can underestimate ECO2. Measurements using AA were compared to measurements using the infrared gas analyzer method (IRGA) over ten months (in rainy and dry seasons), during the day and night, in areas of Caatinga (xeric shrubland and thorn forest) and pasture in the Agreste region of the state of Pernambuco. The ECO2 measurements from AA varied little from night to day and throughout the year or in the rainy and dry seasons. However, those obtained from IRGA were higher in the rainy than in the dry season, but also without significant differences from day to night. The values of both methods were similar in the dry season, but in the rainy season they were higher with the IRGA. Therefore, AA seems to have little sensitivity to seasonal variations, in contrast with measurements from the IRGA, and it may underestimate soil ECO2 when it attains higher values. This result indicates that some of the soil ECO2 values determined in areas of the Brazilian semiarid region, and consequently annual C losses, may have been underestimated.
DOI: 10.6084/m9.figshare.5816427.v1
title: Soil CO2 Efflux Measurements by Alkali Absorption and Infrared Gas Analyzer in the Brazilian Semiarid Region

description: ABSTRACT The CO2 emission from the soil surface, commonly referred to as soil CO2 efflux (ECO2) or soil respiration, is the sum of processes that include root respiration and microbial activity. Measuring this evolution is important to establish sustainable land use models and to estimate global fluxes of carbon, which affect climate change. Despite its importance, few measurements have been made in areas of the semiarid Brazilian Northeast region, and most of them were made using the alkali absorption method (AA), which can underestimate ECO2. Measurements using AA were compared to measurements using the infrared gas analyzer method (IRGA) over ten months (in rainy and dry seasons), during the day and night, in areas of Caatinga (xeric shrubland and thorn forest) and pasture in the Agreste region of the state of Pernambuco. The ECO2 measurements from AA varied little from night to day and throughout the year or in the rainy and dry seasons. However, those obtained from IRGA were higher in the rainy than in the dry season, but also without significant differences from day to night. The values of both methods were similar in the dry season, but in the rainy season they were higher with the IRGA. Therefore, AA seems to have little sensitivity to seasonal variations, in contrast with measurements from the IRGA, and it may underestimate soil ECO2 when it attains higher values. This result indicates that some of the soil ECO2 values determined in areas of the Brazilian semiarid region, and consequently annual C losses, may have been underestimated.
DOI: 10.6084/m9.figshare.5816424
title: Characterization of Cardiopulmonary Exercise Testing Variables in Patients with Endomyocardial Fibrosis after Endocardial Resection

description: Abstract Background: Endomyocardial fibrosis (EMF) is a rare disease, characterized by diastolic dysfunction which leads to reduced peak oxygen consumption (VO2). Cardiopulmonary exercise testing (CPET) has been proved to be a fundamental tool to identify central and peripheral alterations. However, most studies prioritize peak VO2 as the main variable, leaving aside other important CPET variables that can specify the severity of the disease and guide the clinical treatment. Objective: The aim of this study was to evaluate central and peripheral limitations in symptomatic patients with EMF by different CPET variables. Methods: Twenty-six EMF patients (functional class III, NYHA) were compared with 15 healthy subjects (HS). Functional capacity was evaluated using CPET and diastolic and systolic functions were evaluated by echocardiography. Results: Age and gender were similar between EMF patients and HS. Left ventricular ejection fraction was normal in EMF patients, but decreased compared to HS. Peak heart rate, peak workload, peak VO2, peak oxygen (O2) pulse and peak pulmonary ventilation (VE) were decreased in EMF compared to HS. Also, EMF patients showed increased Δ heart rate /Δ oxygen uptake and Δ oxygen uptake /Δ work rate compared to HS. Conclusion: Determination of the aerobic capacity by noninvasive respiratory gas exchange during incremental exercise provides additional information about the exercise tolerance in patients with EMF. The analysis of different CPET variables is necessary to help us understand more about the central and peripheral alterations cause by both diastolic dysfunction and restrictive pattern.
DOI: 10.6084/m9.figshare.5816424.v1
title: Characterization of Cardiopulmonary Exercise Testing Variables in Patients with Endomyocardial Fibrosis after Endocardial Resection

description: Abstract Background: Endomyocardial fibrosis (EMF) is a rare disease, characterized by diastolic dysfunction which leads to reduced peak oxygen consumption (VO2). Cardiopulmonary exercise testing (CPET) has been proved to be a fundamental tool to identify central and peripheral alterations. However, most studies prioritize peak VO2 as the main variable, leaving aside other important CPET variables that can specify the severity of the disease and guide the clinical treatment. Objective: The aim of this study was to evaluate central and peripheral limitations in symptomatic patients with EMF by different CPET variables. Methods: Twenty-six EMF patients (functional class III, NYHA) were compared with 15 healthy subjects (HS). Functional capacity was evaluated using CPET and diastolic and systolic functions were evaluated by echocardiography. Results: Age and gender were similar between EMF patients and HS. Left ventricular ejection fraction was normal in EMF patients, but decreased compared to HS. Peak heart rate, peak workload, peak VO2, peak oxygen (O2) pulse and peak pulmonary ventilation (VE) were decreased in EMF compared to HS. Also, EMF patients showed increased Δ heart rate /Δ oxygen uptake and Δ oxygen uptake /Δ work rate compared to HS. Conclusion: Determination of the aerobic capacity by noninvasive respiratory gas exchange during incremental exercise provides additional information about the exercise tolerance in patients with EMF. The analysis of different CPET variables is necessary to help us understand more about the central and peripheral alterations cause by both diastolic dysfunction and restrictive pattern.
DOI: 10.6084/m9.figshare.5816418
title: Bone-Marrow-Derived Mesenchymal Stromal Cells (MSC) from Diabetic and Nondiabetic Rats Have Similar Therapeutic Potentials

description: Abstract Background: Diabetes mellitus is a severe chronic disease leading to systemic complications, including cardiovascular dysfunction. Previous cell therapy studies have obtained promising results with the use bone marrow mesenchymal stromal cells derived from healthy animals (MSCc) in diabetes animal models. However, the ability of MSC derived from diabetic rats to improve functional cardiac parameters is still unknown. Objectives: To investigate whether bone-marrow-derived MSC from diabetic rats (MSCd) would contribute to recover metabolic and cardiac electrical properties in other diabetic rats. Methods: Diabetes was induced in Wistar rats with streptozotocin. MSCs were characterized by flow cytometry, morphological analysis, and immunohistochemistry. Cardiac electrical function was analyzed using recordings of ventricular action potential. Differences between variables were considered significant when p &lt; 0.05. Results: In vitro properties of MSCc and MSCd were evaluated. Both cell types presented similar morphology, growth kinetics, and mesenchymal profile, and could differentiate into adipogenic and osteogenic lineages. However, in an assay for fibroblast colony-forming units (CFU-F), MSCd formed more colonies than MSCc when cultured in expansion medium with or without hydrocortisone (1 µM). In order to compare the therapeutic potential of the cells, the animals were divided into four experimental groups: nondiabetic (CTRL), diabetic (DM), diabetic treated with MSCc (DM + MSCc), and diabetic treated with MSCd (DM + MSCd). The treated groups received a single injection of MSC 4 weeks after the development of diabetes. MSCc and MSCd controlled hyperglycemia and body weight loss and improved cardiac electrical remodeling in diabetic rats. Conclusions: MSCd and MSCc have similar in vitro properties and therapeutic potential in a rat model of diabetes induced with streptozotocin.
DOI: 10.6084/m9.figshare.5816418.v1
title: Bone-Marrow-Derived Mesenchymal Stromal Cells (MSC) from Diabetic and Nondiabetic Rats Have Similar Therapeutic Potentials

description: Abstract Background: Diabetes mellitus is a severe chronic disease leading to systemic complications, including cardiovascular dysfunction. Previous cell therapy studies have obtained promising results with the use bone marrow mesenchymal stromal cells derived from healthy animals (MSCc) in diabetes animal models. However, the ability of MSC derived from diabetic rats to improve functional cardiac parameters is still unknown. Objectives: To investigate whether bone-marrow-derived MSC from diabetic rats (MSCd) would contribute to recover metabolic and cardiac electrical properties in other diabetic rats. Methods: Diabetes was induced in Wistar rats with streptozotocin. MSCs were characterized by flow cytometry, morphological analysis, and immunohistochemistry. Cardiac electrical function was analyzed using recordings of ventricular action potential. Differences between variables were considered significant when p &lt; 0.05. Results: In vitro properties of MSCc and MSCd were evaluated. Both cell types presented similar morphology, growth kinetics, and mesenchymal profile, and could differentiate into adipogenic and osteogenic lineages. However, in an assay for fibroblast colony-forming units (CFU-F), MSCd formed more colonies than MSCc when cultured in expansion medium with or without hydrocortisone (1 µM). In order to compare the therapeutic potential of the cells, the animals were divided into four experimental groups: nondiabetic (CTRL), diabetic (DM), diabetic treated with MSCc (DM + MSCc), and diabetic treated with MSCd (DM + MSCd). The treated groups received a single injection of MSC 4 weeks after the development of diabetes. MSCc and MSCd controlled hyperglycemia and body weight loss and improved cardiac electrical remodeling in diabetic rats. Conclusions: MSCd and MSCc have similar in vitro properties and therapeutic potential in a rat model of diabetes induced with streptozotocin.