DOI: 10.5061/dryad.8w9ghx41m
title: Vonoprazan pharmacokinetics and effects on gastric pH following administration to fed and fasted horses

description: This dataset supports research characterizing the pharmacokinetics of
 vonoprazan and investigating its effects on gastric pH in horses. The data
 set includes pharmacokinetic parameters for individual horses generated
 using non-compartmental pharmacokinetic analysis and the commercially
 available software program Phoenix WinNonlin (Certara, Princeton, NJ).
 Pharmacokinetic parameters generated from the pilot study (2
 horses/group), assessing the effects of food on drug behavior (0.5 and 1
 mg/kg oral doses), and a “full” study (n=6 horses) assessing the effects
 of a 1 mg/kg oral dose administered with food are included. A second data
 set includes gastric pH measurements as part of the “full” study (n=6
 horses), both before and after vonoprazan administration (1 mg/kg oral
 dose). Measurements were collected via an engineered probe that was used
 to continuously measure intragastric pH for 12 hours before and 24 hours
 after each treatment. Sandhill Scientific software (Milwaukee, WI, USA)
 was used to determine the mean, maximum, and minimum pH. Calculations of
 the %t&gt;pH4 were calculated at different time intervals. While the
 number of horses studied was limited, the results of the current study
 provide data that will be helpful in the design of further studies to
 assess the efficacy of vonoprazan in horses for the treatment of gastric
 ulcers.
description: The study was conducted as a randomised four‐way balanced
 crossover study. Six horses received vonoprazan (0.5 and 1 mg/kg),
 omeprazole (4 mg/kg), and water (60 mL). Blood samples were collected
 prior to and up to 72 h post‐administration. Plasma vonoprazan
 concentrations were measured using liquid chromatography–tandem mass
 spectrometry, and non‐compartmental and compartmental pharmacokinetic
 analyses were performed. Intragastric pH was continuously recorded 12 h
 before and 24 h after each treatment. The percentage of time pH remained
 above 4 was compared among treatments.
description: # Vonoprazan pharmacokinetics and effects on gastric pH following
 administration to fed and fasted horses Dataset DOI:
 [10.5061/dryad.8w9ghx41m](https://doi.org/10.5061/dryad.8w9ghx41m) ##
 Description of the data and file structure The first data set lists
 individual animal pharmacokinetic parameters for both the pilot study (fed
 vs fasted) and the full study (0.5 and 1 mg/kg doses). Parameters were
 generated using non-compartmental analysis (NCA) and the software program
 Phoenix WinNonlin (Certara, Princeton, NJ). The second data set lists % of
 the time that pH was above and below 4 for individual animals. Dose groups
 include 0.5 and 1 mg/kg, omeprazole (positive control), and water
 (negative control). ### Files and variables #### File:
 Pharmacokinetic_Parameters.xlsx **Description:** Pharmacokinetic
 parameters for the pilot and full study as generated by Phoenix WinNonlin
 software and non-compartmental analysis (NCA) ##### Variables * Horse *
 Dose * Lambdaz: terminal slope * HL Lambda z: terminal half-life * Tmax:
 time of maximum concentration * Cmax: maximum measured concentration * AUC
 inf: area under the curve extrapolated to infinity * AUC% % extrap:
 percentage of the curve that is extrapolated #### File:
 Vonoprazan_pH_Assessments.xlsx **Description:** pH assessments (time above
 and below pH4 ) for the dose groups ##### Variables * Pre-%pH above 4:
 time pH is above 4 before drug administration * Pre-%pH below 4: time pH
 is below 4 before drug administration * Post-%pH above 4: time pH is above
 4 after drug administration * Post-%pH below 4: time pH is below 4 after
 drug administration ## Code/software No software is needed to view data.
 Any program that will open a spreadsheet, such as Excel, is recommended.
 For PK analysis, the Phoenix NLME software program (V8.3; Certara,
 Princeton, NJ) was used. Sandhill Scientific software (Milwaukee, WI, USA)
 was used to determine the mean, maximum, and minimum pH, and calculations
 of the %t&gt;pH4. ## Access information Other publicly accessible
 locations of the data: * None Data was derived from the following sources:
 * None