cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.5281/zenodo.8360040
title: Exploiting Vector Pattern Diversity of Molecular Scaffolds for Cheminformatics Tasks in Drug Discovery

description: Data and code to accompany the paper: <em>Exploiting Vector Pattern Diversity of Molecular Scaffolds for Cheminformatics Tasks in Drug Discovery. </em>
DOI: 10.5281/zenodo.8360039
title: Exploiting Vector Pattern Diversity of Molecular Scaffolds for Cheminformatics Tasks in Drug Discovery

description: Data and code to accompany the paper: <em>Exploiting Vector Pattern Diversity of Molecular Scaffolds for Cheminformatics Tasks in Drug Discovery. </em>
DOI: 10.6084/m9.figshare.24289318
title: Supplementary Material for: The balance of CD8-positive T cells and PD-L1 expression in the myocardium predicts prognosis in lymphocytic fulminant myocarditis

description: Introduction: The clinical significance and prognostic value of T cell involvement and programmed cell death-1 (PD-1)/programmed cell death ligand-1 (PD-L1) have not been established in lymphocytic fulminant myocarditis (FM). We investigated the prognostic impact of the number of CD4+, CD8+, FoxP3+, and PD-1+ T cells, as well as PD-L1 expression, in cardiomyocytes in lymphocytic FM. Methods: This is a single-center observational cohort study. Myocardial tissue was obtained from 16 consecutive patients at lymphocytic FM onset. The median follow-up was 140 days. Cardiac events were defined as a composite of cardiac death and left ventricular-assist device implantation. CD4, CD8, FoxP3, PD-1, and PD-L1 immunostaining was performed on myocardial specimens. Results: The median age of the patients was 52 years (seven men and nine women). There was no significant difference in the number of CD4+ cells. The number of CD8+ cells and the CD8+/CD4+ T cell ratio were higher in the cardiac event group (Event+) than in the group without cardiac events (Event−) (P = 0.048 and P = 0.022, respectively). The number of FoxP3+ T cells was higher in the Event+ group (P = 0.049). Although there was no difference in the number of PD-1+ cells, cardiomyocyte PD-L1 expression was higher in the Event+ group (P = 0.112). Event-free survival was worse in the group with a high CD8+ cell count (P = 0.012) and high PD-L1 expression (P = 0.049). When divided into three groups based on the number of CD8+ cells and PD-L1 expression (CD8highPD-L1high [n = 8], CD8lowPD-L1high [n = 1], and CD8lowPD-L1low [n = 7]), the CD8highPD-L1high group demonstrated the worst event-free survival, while the CD8lowPD-L1high group had a favorable prognosis without cardiac events (P = 0.041). Conclusion: High myocardial expression of CD8+ T cells and PD-L1 may predict a poor prognosis in lymphocytic FM.
DOI: 10.6084/m9.figshare.24289318.v1
title: Supplementary Material for: The balance of CD8-positive T cells and PD-L1 expression in the myocardium predicts prognosis in lymphocytic fulminant myocarditis

description: Introduction: The clinical significance and prognostic value of T cell involvement and programmed cell death-1 (PD-1)/programmed cell death ligand-1 (PD-L1) have not been established in lymphocytic fulminant myocarditis (FM). We investigated the prognostic impact of the number of CD4+, CD8+, FoxP3+, and PD-1+ T cells, as well as PD-L1 expression, in cardiomyocytes in lymphocytic FM. Methods: This is a single-center observational cohort study. Myocardial tissue was obtained from 16 consecutive patients at lymphocytic FM onset. The median follow-up was 140 days. Cardiac events were defined as a composite of cardiac death and left ventricular-assist device implantation. CD4, CD8, FoxP3, PD-1, and PD-L1 immunostaining was performed on myocardial specimens. Results: The median age of the patients was 52 years (seven men and nine women). There was no significant difference in the number of CD4+ cells. The number of CD8+ cells and the CD8+/CD4+ T cell ratio were higher in the cardiac event group (Event+) than in the group without cardiac events (Event−) (P = 0.048 and P = 0.022, respectively). The number of FoxP3+ T cells was higher in the Event+ group (P = 0.049). Although there was no difference in the number of PD-1+ cells, cardiomyocyte PD-L1 expression was higher in the Event+ group (P = 0.112). Event-free survival was worse in the group with a high CD8+ cell count (P = 0.012) and high PD-L1 expression (P = 0.049). When divided into three groups based on the number of CD8+ cells and PD-L1 expression (CD8highPD-L1high [n = 8], CD8lowPD-L1high [n = 1], and CD8lowPD-L1low [n = 7]), the CD8highPD-L1high group demonstrated the worst event-free survival, while the CD8lowPD-L1high group had a favorable prognosis without cardiac events (P = 0.041). Conclusion: High myocardial expression of CD8+ T cells and PD-L1 may predict a poor prognosis in lymphocytic FM.
DOI: 10.6084/m9.figshare.24025389
title: Phylogenetic analysis of Newcastle disease virus detected in Eritrea between 2017 and 2021

description: Thirty-five samples collected from chickens in 13 commercial farms in Eritrea between 2017 and 2021 following reports of disease were screened for Newcastle disease virus. Seventeen samples (50%) were shown to be positive by RT–PCR. An initial analysis of partial fusion (F) gene sequences of 10 representative samples indicated that the viruses belonged to subgenotype VII.1.1. Subsequently, full F gene sequence analysis of four of these representative samples confirmed the genotype of the viruses but also revealed that they were not identical to each other suggesting different origins of the VII.1.1 subgenotype viruses circulating in Eritrea. These data have implications for the control of Newcastle disease within the poultry population in Eritrea.
DOI: 10.6084/m9.figshare.24025389.v1
title: Phylogenetic analysis of Newcastle disease virus detected in Eritrea between 2017 and 2021

description: Thirty-five samples collected from chickens in 13 commercial farms in Eritrea between 2017 and 2021 following reports of disease were screened for Newcastle disease virus. Seventeen samples (50%) were shown to be positive by RT–PCR. An initial analysis of partial fusion (F) gene sequences of 10 representative samples indicated that the viruses belonged to subgenotype VII.1.1. Subsequently, full F gene sequence analysis of four of these representative samples confirmed the genotype of the viruses but also revealed that they were not identical to each other suggesting different origins of the VII.1.1 subgenotype viruses circulating in Eritrea. These data have implications for the control of Newcastle disease within the poultry population in Eritrea.
DOI: 10.6084/m9.figshare.24289348
title: Supplementary Material for: Correlation of Neuroendocrine Differentiation with A Distinctively Suppressive Immune Microenvironment in Gastric Cancer

description: Introduction Neuroendocrine neoplasms (NENs) harbored significantly suppressive tumor immune microenvironments (TIMEs). However, the immunological effects of neuroendocrine differentiation (NED) on non-NE neoplasms, such as gastric cancer (GC), were unknown. Methods Between pure gastric cancer (PGC) and GC-NED, TIME features were scored based on expression data and validated on serial whole-tissue sections of surgical samples, with tertiary lymphoid structures (TLSs) and the extra-TLS zone evaluated independently using multi-marker immunohistochemical staining. Risk analyses of TIME features on tumor behaviors were performed in GC-NED. The universal immunological effects of NED were explored preliminarily in adenocarcinomas arising in other organs. Results Based on over 11,500 annotated TLSs and 2,700 extra-TLS zones, compared with PGC, GC-NED harbored a distinctively more suppressive TIME characterized by increased but immature TLSs, with higher naïve B cell and follicular regulatory T cell densities and downregulated TLS maturation-related cell ratios inside TLSs; increased naïve B cell and regulatory T cell densities and a high proportion of exhausted T cells in the extra-TLS zone. The upregulated tumor PD-L1 expression and its close correlations with TLS formation and maturation were remarkable exclusively in GC-NED. TIME features, especially those regarding TLSs, were significantly correlated with tumor growth and invasion. The desynchrony between TLS formation and maturation and increased naïve or regulatory immune cell infiltration was observed in adenocarcinomas of the colorectum, pancreas, lung, and prostate. Conclusion NED highlighted a distinct GC entity with more suppressive TIME features correlated with tumor behaviors, indicating a cohort that would benefit more from immunotherapies.
DOI: 10.6084/m9.figshare.24289348.v1
title: Supplementary Material for: Correlation of Neuroendocrine Differentiation with A Distinctively Suppressive Immune Microenvironment in Gastric Cancer

description: Introduction Neuroendocrine neoplasms (NENs) harbored significantly suppressive tumor immune microenvironments (TIMEs). However, the immunological effects of neuroendocrine differentiation (NED) on non-NE neoplasms, such as gastric cancer (GC), were unknown. Methods Between pure gastric cancer (PGC) and GC-NED, TIME features were scored based on expression data and validated on serial whole-tissue sections of surgical samples, with tertiary lymphoid structures (TLSs) and the extra-TLS zone evaluated independently using multi-marker immunohistochemical staining. Risk analyses of TIME features on tumor behaviors were performed in GC-NED. The universal immunological effects of NED were explored preliminarily in adenocarcinomas arising in other organs. Results Based on over 11,500 annotated TLSs and 2,700 extra-TLS zones, compared with PGC, GC-NED harbored a distinctively more suppressive TIME characterized by increased but immature TLSs, with higher naïve B cell and follicular regulatory T cell densities and downregulated TLS maturation-related cell ratios inside TLSs; increased naïve B cell and regulatory T cell densities and a high proportion of exhausted T cells in the extra-TLS zone. The upregulated tumor PD-L1 expression and its close correlations with TLS formation and maturation were remarkable exclusively in GC-NED. TIME features, especially those regarding TLSs, were significantly correlated with tumor growth and invasion. The desynchrony between TLS formation and maturation and increased naïve or regulatory immune cell infiltration was observed in adenocarcinomas of the colorectum, pancreas, lung, and prostate. Conclusion NED highlighted a distinct GC entity with more suppressive TIME features correlated with tumor behaviors, indicating a cohort that would benefit more from immunotherapies.
DOI: 10.17638/datacat.liverpool.ac.uk/2482
title: NMR, MS and Single-Molecule Conductance Data for a set of Cyclometalated Pt(II) molecular wires and their precursors.

description: As in title.
description: See README
DOI: 10.5281/zenodo.8425964
title: NEW REFERENCE HVDC DIVIDER FOR THE CALIBRATION OF TESTING EQUIPMENT UP TO 1600 kV

description: An international metrology project named “EMPIR 19ENG02 FutureEnergy” started in June 2020, is developing, building, and evaluating measurement equipment and systems for the UHV level. This paper describes the work on a new reference UHVDC voltage divider for the calibration of testing equipment up to at least 1600 kV. This divider has a modular design and target expanded measurement uncertainty of 200 μV/V. The need for such measurement systems results from new measurement methods for future energy transmission grids. After the construction of the UHVDC voltage divider, the targeted measurement uncertainty of 200 μV/V was successfully at 1200 kV during a measurement campaign at PTB. The linearity and temperature dependence of the UHVDC divider modules as well as the overall results of this new divider are included in this work. This work will lead to new calibration and measurement capabilities (CMC) for traceability of the designed divider systems for participating national metrology institutes (NMI).
DOI: 10.5281/zenodo.8425963
title: NEW REFERENCE HVDC DIVIDER FOR THE CALIBRATION OF TESTING EQUIPMENT UP TO 1600 kV

description: An international metrology project named “EMPIR 19ENG02 FutureEnergy” started in June 2020, is developing, building, and evaluating measurement equipment and systems for the UHV level. This paper describes the work on a new reference UHVDC voltage divider for the calibration of testing equipment up to at least 1600 kV. This divider has a modular design and target expanded measurement uncertainty of 200 μV/V. The need for such measurement systems results from new measurement methods for future energy transmission grids. After the construction of the UHVDC voltage divider, the targeted measurement uncertainty of 200 μV/V was successfully at 1200 kV during a measurement campaign at PTB. The linearity and temperature dependence of the UHVDC divider modules as well as the overall results of this new divider are included in this work. This work will lead to new calibration and measurement capabilities (CMC) for traceability of the designed divider systems for participating national metrology institutes (NMI).
DOI: 10.5281/zenodo.8430935
title: Energy budget of the sea cucumber Neostchopus grammatus fed abalone waste

description: The data is gotten from Energy budget of the sea cucumber <em>Neostichopus</em> <em>grammatus </em>fed abalone waste.
DOI: 10.5281/zenodo.8430936
title: Energy budget of the sea cucumber Neostchopus grammatus fed abalone waste

description: The data is gotten from Energy budget of the sea cucumber <em>Neostichopus</em> <em>grammatus </em>fed abalone waste.
DOI: 10.4121/4a9dac6d-dd4e-4dc2-a5ba-72e35d86ac93.v1
title: Data underlying the publication: Sizing batteries for power flow management in distribution grids

description: Includes the following datasets:The IEEE Test Grid Excel file which is read into the Python model to generate the test grid (.xlsx file).Load Patterns used for consumer connections in the Python model, with variable simultaneity (simultaneity % is indicated after the '_' in the file name) (.csv files).A generation pattern file used in the Python model. The file is currently filled with 0's, but can be adapted to test decentral generation effects (.csv file).The final results and data analysis (.xlsm file).<br>Also included is the .py file with the code used to simulate power flows in the grid.
DOI: 10.48328/tudatalib-1179
title: Supplementary Material (Data): Do Resilience Metrics of Water Distribution Systems Really Assess Resilience? A Critical Review

description: This dataset contains the data for the paper "Do Resilience Metrics of Water Distribution Systems Really Assess Resilience? A Critical Review". It contains the table with the categoriation of WDS resilience metrics and a table with literature search protocol.
DOI: 10.22008/fk2/ox5crv
title: Datafile for GEUS report 2023/12

description: Datafile for GEUS report 2023/12 The datafile includes one zipped folder with grid result files and one zipped filedatabase (esri gdb) with polygons and a table. All files in the two folders are described in detail in GEUS report 2023/12
DOI: 10.25392/leicester.data.24289315
title: Simulations data for the article "Analysis of probability of inserting a hard spherical particle with small diameter in hard-sphere fluid" published in the Journal of Chemical Physics

description: The files probability_jcp_V2V3.txt contains simulation results for the average pair and triple intersection volume in a hard-sphere fluid at different packing fractions (eta) and different test sphere diameters (sigma). '(CI)' columns contain the estimated 95% cofidence intervals (i.e., twice the estimated standard deviations) for the corresponding data values.
DOI: 10.25392/leicester.data.24289315.v1
title: Simulations data for the article "Analysis of probability of inserting a hard spherical particle with small diameter in hard-sphere fluid" published in the Journal of Chemical Physics

description: The files probability_jcp_V2V3.txt contains simulation results for the average pair and triple intersection volume in a hard-sphere fluid at different packing fractions (eta) and different test sphere diameters (sigma). '(CI)' columns contain the estimated 95% cofidence intervals (i.e., twice the estimated standard deviations) for the corresponding data values.
DOI: 10.6084/m9.figshare.24289684
title: Supplementary Material for: Revisiting the predictive role of truncal-type occlusion sign for acute large vessel stroke treated by endovascular thrombectomy: A scoping review

description: Abstract Background and purpose The truncal type occlusion (TTO) sign observed during endovascular thrombectomy (EVT) is thought to predict the etiology and prognosis of acute ischemic stroke (AIS) due to large vessel occlusion (LVO). However, the interpretation of the present results and the clinical utility of this sign needs further investigation. This scoping meta-review aimed to assess the predictive value of the TTO sign, thus identifying methodological limitations in current study designs. Methods Studies published up to January 2023 were identified by systematically searching PubMed, Embase, and Web of Science. A meta-analysis was performed to quantitatively synthesize the evidence on the predictive value of the TTO sign. An 8-point scale was introduced to narratively summarize the current evidence level and methodological quality of included studies. Results We included 10 studies in this review. For the prediction of intracranial atherosclerotic stenosis, the sensitivity, specificity, PLR and NLR of the TTO sign were 0.73, 0.87, 5.5 and 0.31, respectively (all p&lt;0.05). For recanalization failure after primary thrombectomy, the sensitivity, specificity, PLR and NLR were 0.44, 0.91, 4.9 and 0.61, respectively (all p&lt;0.05). The strength of evidence was low due to the methodological limitations and lack of adjustment for potential confounders. Conclusion The predictive values of the TTO sign for the etiology of LVO-AIS was considerable but seemed limited for current interpretation. Several confounders could influence the determination and predictive value of the TTO sign, requiring methodological adjustments in future research. Endovascular practitioners encountering this sign during thrombectomy should draw specific attention to stroke etiology, thus promoting timely adjustment of intra- and postprocedural strategies.
DOI: 10.6084/m9.figshare.24289684.v1
title: Supplementary Material for: Revisiting the predictive role of truncal-type occlusion sign for acute large vessel stroke treated by endovascular thrombectomy: A scoping review

description: Abstract Background and purpose The truncal type occlusion (TTO) sign observed during endovascular thrombectomy (EVT) is thought to predict the etiology and prognosis of acute ischemic stroke (AIS) due to large vessel occlusion (LVO). However, the interpretation of the present results and the clinical utility of this sign needs further investigation. This scoping meta-review aimed to assess the predictive value of the TTO sign, thus identifying methodological limitations in current study designs. Methods Studies published up to January 2023 were identified by systematically searching PubMed, Embase, and Web of Science. A meta-analysis was performed to quantitatively synthesize the evidence on the predictive value of the TTO sign. An 8-point scale was introduced to narratively summarize the current evidence level and methodological quality of included studies. Results We included 10 studies in this review. For the prediction of intracranial atherosclerotic stenosis, the sensitivity, specificity, PLR and NLR of the TTO sign were 0.73, 0.87, 5.5 and 0.31, respectively (all p&lt;0.05). For recanalization failure after primary thrombectomy, the sensitivity, specificity, PLR and NLR were 0.44, 0.91, 4.9 and 0.61, respectively (all p&lt;0.05). The strength of evidence was low due to the methodological limitations and lack of adjustment for potential confounders. Conclusion The predictive values of the TTO sign for the etiology of LVO-AIS was considerable but seemed limited for current interpretation. Several confounders could influence the determination and predictive value of the TTO sign, requiring methodological adjustments in future research. Endovascular practitioners encountering this sign during thrombectomy should draw specific attention to stroke etiology, thus promoting timely adjustment of intra- and postprocedural strategies.
DOI: 10.6084/m9.figshare.24288964
title: Mouse hearts after myocardial infarct

description: Data set contains samples from isolated cells of murine hearts after myocardial infarction (LAD surgery). We used an endothelial tracing system to mark endothelial cells with EGFP prior to infarct. In brief, Cdh5-ERT2+/-;mT/mG mice, which were used at an age of 10-12 weeks. Cre expression was induced by daily intraperitoneal injections of 2 mg tamoxifen for 1 week in all mice. One week after tamoxifen injection, left anterior descending coronary artery ligation surgery was performed, inducing myocardial infarction. We collected samples at homeostasis, days(d) 1, 3, 7, 14 and 28 after infarction and isolated the non-cardiomyocyte fraction for single cell sequencing. Murine scRNA-seq libraries were prepared using Chromium Single Cell 3′ v3 Reagent Kit (10X Genomics), according to manufacturer’s protocols. Raw reads were mapped against a customized version of mm10 (GRCm38.p4) containing sequences of EGFP and tdTomato.
DOI: 10.57967/hf/1200
title: DFP
DOI: 10.6084/m9.figshare.24289984
title: Supplementary Material for: Age-dependent Effects of Transgenic 2D2 Mice Used to Induce Passive EAE in C57BL/6 Mice

description: Introduction: Multiple sclerosis (MS) is a neurodegenerative autoimmune disease which worsens with age. Here we examined the influence of age on passive experimental autoimmune encephalomyelitis (P-EAE), a model to study MS, using young and mature adult 2D2 transgenic donor mice to induce pathology in WT C57BL6/J mice. Methods: Lymphocytes from young adult (i.e., 10-week-old) or mature adult (i.e., 6-month-old) transgenic donor mice were characterized by flow cytometry prior to injection of cultured leukocytes into adult female WT recipient mice, with a special focus on transgenic T cell phenotypes. Results: Our findings show age-dependent changes in memory T cell phenotypes correlated with more severe clinical and histological disease when donor cells originated from young as compared to mature adult mice. Conclusion: Not only do these results demonstrate that the age of the 2D2 transgenic donor mice is critical in establishing P-EAE, but the differential effects might also identify age-dependent factors that contribute to EAE and perhaps MS.
DOI: 10.6084/m9.figshare.24289984.v1
title: Supplementary Material for: Age-dependent Effects of Transgenic 2D2 Mice Used to Induce Passive EAE in C57BL/6 Mice

description: Introduction: Multiple sclerosis (MS) is a neurodegenerative autoimmune disease which worsens with age. Here we examined the influence of age on passive experimental autoimmune encephalomyelitis (P-EAE), a model to study MS, using young and mature adult 2D2 transgenic donor mice to induce pathology in WT C57BL6/J mice. Methods: Lymphocytes from young adult (i.e., 10-week-old) or mature adult (i.e., 6-month-old) transgenic donor mice were characterized by flow cytometry prior to injection of cultured leukocytes into adult female WT recipient mice, with a special focus on transgenic T cell phenotypes. Results: Our findings show age-dependent changes in memory T cell phenotypes correlated with more severe clinical and histological disease when donor cells originated from young as compared to mature adult mice. Conclusion: Not only do these results demonstrate that the age of the 2D2 transgenic donor mice is critical in establishing P-EAE, but the differential effects might also identify age-dependent factors that contribute to EAE and perhaps MS.
DOI: 10.5519/qd.w1te4a0n
title: Query on the Natural History Museum Data Portal (data.nhm.ac.uk) (28 records)
DOI: 10.5283/epub.54804
title: Wild Type Berlin Torque Learning, left+right