cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.11365301.v1
title: RA_16s_rRNA_File2

description: RA patients and healthy control 16s rRNA v3-v4 sequencing
DOI: 10.6084/m9.figshare.11365274.v1
title: RA_16s_rRNA_File1

description: RA patients and healthy controls 16s rRNA v3-v4 sequencing
DOI: 10.6084/m9.figshare.11365235
title: A utility-aware multi-task scheduling method in cloud manufacturing using extended NSGA-II embedded with game theory

description: This is the experimental data of the manuscript entitled "A utility-aware multi-task scheduling method in cloud manufacturing using extended NSGA-II embedded with game theory". All data are generated through computer simulation and saved in the file with csv format. The data are the simulation of the real-world case. There are nine instances for these experiments, which cover multiple scales. Three attributes including time, cost, and reliability of servies for achieving corresponding subtasks are shown in datasets.
DOI: 10.6084/m9.figshare.11365205
title: Clinical significance of follow-up blood culture in patients with a single <i>Staphylococcus aureus</i>-positive blood culture

description: <b>Background:</b> We evaluated the frequency of a positive result in follow-up blood cultures (FUBCs) and clinical outcome when FUBCs were not performed, in patients with a single <i>Staphylococcus aureus</i>-positive blood culture. <b>Methods:</b> We analyzed blood culture results in a prospective, observational cohort of patients with <i>S. aureus</i> bacteraemia (SAB) at a tertiary-care hospital. All adult patients with only a single positive blood culture set from at least two blood culture sets drawn at the initial SAB episode were enrolled in the study. We analyzed FUBC results performed within 5 days after bacteraemia onset and compared the characteristics and outcomes between patients with and without FUBCs. <b>Results:</b> Of 305 patients with a single <i>S. aureus</i>-positive blood culture, FUBCs were obtained in 274 (90%) and were positive in 15% (42/274), of whom 50% were afebrile. The rate of positivity of FUBCs was significantly higher in methicillin-resistant <i>S. aureus</i> (MRSA) than in methicillin-susceptible <i>S. aureus</i> (19% versus 9%, <i>p</i> = .03). In 190 patients with a single MRSA-positive blood culture, the demographic and clinical characteristics were similar between patients with and without FUBCs (167 versus 23). Although mortality was comparable between the two groups, relapse of SAB was significantly more frequent in patients in whom FUBCs were not performed (17% versus 2%, <i>p</i> = .008). <b>Conclusions:</b> Even if a patient has a single <i>S. aureus</i>-positive blood culture and no fever, FUBCs should be performed to manage the infection properly and to prevent SAB relapse.
DOI: 10.6084/m9.figshare.11365205.v1
title: Clinical significance of follow-up blood culture in patients with a single <i>Staphylococcus aureus</i>-positive blood culture

description: <b>Background:</b> We evaluated the frequency of a positive result in follow-up blood cultures (FUBCs) and clinical outcome when FUBCs were not performed, in patients with a single <i>Staphylococcus aureus</i>-positive blood culture. <b>Methods:</b> We analyzed blood culture results in a prospective, observational cohort of patients with <i>S. aureus</i> bacteraemia (SAB) at a tertiary-care hospital. All adult patients with only a single positive blood culture set from at least two blood culture sets drawn at the initial SAB episode were enrolled in the study. We analyzed FUBC results performed within 5 days after bacteraemia onset and compared the characteristics and outcomes between patients with and without FUBCs. <b>Results:</b> Of 305 patients with a single <i>S. aureus</i>-positive blood culture, FUBCs were obtained in 274 (90%) and were positive in 15% (42/274), of whom 50% were afebrile. The rate of positivity of FUBCs was significantly higher in methicillin-resistant <i>S. aureus</i> (MRSA) than in methicillin-susceptible <i>S. aureus</i> (19% versus 9%, <i>p</i> = .03). In 190 patients with a single MRSA-positive blood culture, the demographic and clinical characteristics were similar between patients with and without FUBCs (167 versus 23). Although mortality was comparable between the two groups, relapse of SAB was significantly more frequent in patients in whom FUBCs were not performed (17% versus 2%, <i>p</i> = .008). <b>Conclusions:</b> Even if a patient has a single <i>S. aureus</i>-positive blood culture and no fever, FUBCs should be performed to manage the infection properly and to prevent SAB relapse.
DOI: 10.6084/m9.figshare.11365235.v1
title: A utility-aware multi-task scheduling method in cloud manufacturing using extended NSGA-II embedded with game theory

description: This is the experimental data of the manuscript entitled "A utility-aware multi-task scheduling method in cloud manufacturing using extended NSGA-II embedded with game theory". All data are generated through computer simulation and saved in the file with csv format. The data are the simulation of the real-world case. There are nine instances for these experiments, which cover multiple scales. Three attributes including time, cost, and reliability of servies for achieving corresponding subtasks are shown in datasets.
DOI: 10.6084/m9.figshare.11365181
title: Administration timing and duration-dependent effects of sesamin isomers on lipid metabolism in rats

description: Metabolism of lipids such as cholesterol and triglycerides has daily variations and is controlled by a circadian clock. Sesamin isomers, a mixture of sesamin and episesamin (SE), are types of lignans in sesame seed that have shown the improvement of lipid metabolism with various diseases in an animal model. We therefore tested whether the effects of SE on lipid metabolism are influenced by timing of administration. High-fat diet (HFD)-loaded rat was administered SE in the ZT13 or 14 (at the beginning of the active phase) or ZT23 or 22 (at the end of the active phase) every day for 7 or 28 days, and the effects on lipid metabolism were evaluated. The effects of SE were enhanced by duration-dependency: 28-day administration of SE strongly affected some parameters related to lipid metabolism, particularly cholesterol metabolism, as compared to 7-day administration. In particular, in 28-day administration, the analysis of serum and liver cholesterol levels revealed that SE administration decreases more effectively at the beginning of the active phase when compared to at the end of that. Furthermore, quantitative real-time polymerase chain reaction (QRT-PCR) and functional analysis indicated that suppression of cholesterol synthesis in the liver and promotion of cholesterol excretion from the liver, as well as inhibition of the functional activity and gene expression of sterol response element-binding protein 2 (Srebp2), which is a transcriptional factor and controls the gene expression involved in cholesterol-metabolism enzymes, contribute to enhancement of SE’s effects at this administration timing. No significant differences were observed in triglyceride metabolism with regard to timing of SE administration. After 28-day administration of SE, administration at the beginning of the active phase only affected the expression of clock genes in the liver with phase-advance. In the pharmacokinetic study, administration time had no effect on the level of sesamin, episesamin or their metabolites in the liver after administration of SE for 28 days. The present results suggest that continuous long administration of SE at the beginning of the active phase is preferable for obtaining beneficial effects on lipid metabolism.
DOI: 10.6084/m9.figshare.11365181.v1
title: Administration timing and duration-dependent effects of sesamin isomers on lipid metabolism in rats

description: Metabolism of lipids such as cholesterol and triglycerides has daily variations and is controlled by a circadian clock. Sesamin isomers, a mixture of sesamin and episesamin (SE), are types of lignans in sesame seed that have shown the improvement of lipid metabolism with various diseases in an animal model. We therefore tested whether the effects of SE on lipid metabolism are influenced by timing of administration. High-fat diet (HFD)-loaded rat was administered SE in the ZT13 or 14 (at the beginning of the active phase) or ZT23 or 22 (at the end of the active phase) every day for 7 or 28 days, and the effects on lipid metabolism were evaluated. The effects of SE were enhanced by duration-dependency: 28-day administration of SE strongly affected some parameters related to lipid metabolism, particularly cholesterol metabolism, as compared to 7-day administration. In particular, in 28-day administration, the analysis of serum and liver cholesterol levels revealed that SE administration decreases more effectively at the beginning of the active phase when compared to at the end of that. Furthermore, quantitative real-time polymerase chain reaction (QRT-PCR) and functional analysis indicated that suppression of cholesterol synthesis in the liver and promotion of cholesterol excretion from the liver, as well as inhibition of the functional activity and gene expression of sterol response element-binding protein 2 (Srebp2), which is a transcriptional factor and controls the gene expression involved in cholesterol-metabolism enzymes, contribute to enhancement of SE’s effects at this administration timing. No significant differences were observed in triglyceride metabolism with regard to timing of SE administration. After 28-day administration of SE, administration at the beginning of the active phase only affected the expression of clock genes in the liver with phase-advance. In the pharmacokinetic study, administration time had no effect on the level of sesamin, episesamin or their metabolites in the liver after administration of SE for 28 days. The present results suggest that continuous long administration of SE at the beginning of the active phase is preferable for obtaining beneficial effects on lipid metabolism.
DOI: 10.6084/m9.figshare.11365115
title: Supplementary Material for: Research Themes and Trends in Ten Top-Ranked Nephrology Journals: A Text Mining Analysis

description: <b><i>Background:</i></b> Nephrology research is expanding, and harnessing the much-needed information and data for the practice of evidence-based medicine is becoming more challenging. In this study, we used the natural language processing and text mining approach to mitigate some of these challenges. <b><i>Methods:</i></b> We analyzed 17,412 abstracts from the top-10 nephrology journals over 10 years (2007–2017) by using latent semantic analysis and topic analysis. <b><i>Results:</i></b> The analyses revealed 10 distinct topics (T) for nephrology research ranging from basic science studies, using animal modeling (T-1), to dialysis vascular access-related issues ­(T-10). The trend analyses indicated that while the majority of topics stayed relatively stable, some of the research topics experienced increasing popularity over time such as studies focusing on mortality and survival (T-4) and Patient-related Outcomes and Perspectives of Clinicians (T-5). However, some research topics such as studies focusing on animal modeling (T-1), predictors of acute kidney injury, and dialysis access (T-10) exhibited a downward trend. <b><i>Conclusion:</i></b> Stakeholders of nephrology research may use these trends further to develop priorities and enrich the research agenda for the future.
DOI: 10.6084/m9.figshare.11365082
title: Supporting data for an analysis of HBV viral load distribution and set point in chronic infection: retrospective analysis of cohorts from the UK and South Africa

description: The two data files (.xlsx) are the supporting metadata for an analysis of the distribution and set point of hepatitis B virus (HBV) viral loads in adults with chronic infection, comparing cohorts from the UK and from South Africa. We have also included viral load data for Hepatitis C virus (HCV) and Human Immunodeficiency Virus (HIV) for comparison. <br><b>Suppl Fig 1: Relationship between hepatitis B viral load, HBeAg status and (A) sex, (B) age, and (C) ethnicity, in a cohort of adults with chronic hepatitis B virus infection recruited in Oxford, UK</b>. Data shown for 351 individuals, of whom 304 HBeAg-negative and 47 HBeAg-positive. Number of participants in each category marked on individual bars, with total number in each plot reduced as a result of missing data for individual patients. Ethnicity based on self-reported data using standardised ethnicity codes. Categories for Chinese and Indian groups shown separately from other Asian patients.<br><br>Data collection for the UK cohort was approved by the NRES Committee South Central-Oxford C (ref: 15/SC/0523). South African data collection was approved by the Health Sciences Research Ethics Committee at the University of the Free State; reference UFS-HSD2019/0044/2603. <br> p.p1 {margin: 0.0px 0.0px 0.0px 0.0px; text-align: justify; font: 11.0px Arial} span.s1 {font-kerning: none}
DOI: 10.6084/m9.figshare.11365082.v1
title: Supporting data for an analysis of HBV viral load distribution and set point in chronic infection: retrospective analysis of cohorts from the UK and South Africa

description: The two data files are the supporting metadata for an analysis of the distribution and set point of hepatitis B virus (HBV) viral loads in adults with chronic infection, comparing cohorts from the UK and from South Africa.<br><b>Suppl Fig 1: </b>Relationship between hepatitis B viral load, HBeAg status and (A) sex, (B) age, and (C) ethnicity, in a cohort of 351 individuals with chronic hepatitis B virus infection recruited in Oxford, UK<br>Data collection for the UK cohort was approved by the NRES Committee South Central-Oxford C (ref: 15/SC/0523). South African data collection was approved by the Health Sciences Research Ethics Committee at the University of the Free State; reference UFS-HSD2019/0044/2603. <br>
DOI: 10.6084/m9.figshare.11365031
title: Supplementary Material for: An Overview of Systematic Reviews of Randomized-Controlled Trials for Preventing Necrotizing Enterocolitis in Preterm Infants

description: Necrotizing enterocolitis (NEC) remains a major cause for neonatal mortality and morbidity in preterm infants. The purpose of this review was to summarize evidence from systematic reviews of randomized-controlled trials (RCTs) regarding antenatal and postnatal interventions for preventing NEC. PubMed, EMBASE, the Cochrane Library Databases, Database of Abstracts of Reviews of Effects, and Campbell Library were searched for meta-analyses in which NEC was reported as an outcome after antenatal or postnatal strategies. The AMSTAR instrument was used to evaluate quality of included reviews. Grading of Recommendations, Assessment, Development and Evaluation assessment was used to evaluate certainty of evidence. We identified 98 meta-analyses of RCTs. The quality of included reviews was adequate, whereas the certainty of evidence was moderate to very low. Moderate certainty evidence showed a reduction in NEC following administration of a combination of species of probiotics, probiotics (any), antenatal corticosteroids in pregnant women at risk of preterm birth, and ibuprofen versus indomethacin for treatment of patent ductus arteriosus (PDA). For surgical NEC, moderate certainty evidence showed an increased risk with lower (85–89%) oxygen saturation target levels, compared with higher (91–95%) oxygen saturation target levels. In conclusion, decreased risk of NEC is observed with probiotics, antenatal corticosteroids for women at risk of preterm birth, and ibuprofen versus indomethacin for treatment of PDA. Targeting lower oxygen saturations may increase the risk of surgical NEC, compared to targeting higher saturations.
DOI: 10.6084/m9.figshare.11365031.v1
title: Supplementary Material for: An Overview of Systematic Reviews of Randomized-Controlled Trials for Preventing Necrotizing Enterocolitis in Preterm Infants

description: Necrotizing enterocolitis (NEC) remains a major cause for neonatal mortality and morbidity in preterm infants. The purpose of this review was to summarize evidence from systematic reviews of randomized-controlled trials (RCTs) regarding antenatal and postnatal interventions for preventing NEC. PubMed, EMBASE, the Cochrane Library Databases, Database of Abstracts of Reviews of Effects, and Campbell Library were searched for meta-analyses in which NEC was reported as an outcome after antenatal or postnatal strategies. The AMSTAR instrument was used to evaluate quality of included reviews. Grading of Recommendations, Assessment, Development and Evaluation assessment was used to evaluate certainty of evidence. We identified 98 meta-analyses of RCTs. The quality of included reviews was adequate, whereas the certainty of evidence was moderate to very low. Moderate certainty evidence showed a reduction in NEC following administration of a combination of species of probiotics, probiotics (any), antenatal corticosteroids in pregnant women at risk of preterm birth, and ibuprofen versus indomethacin for treatment of patent ductus arteriosus (PDA). For surgical NEC, moderate certainty evidence showed an increased risk with lower (85–89%) oxygen saturation target levels, compared with higher (91–95%) oxygen saturation target levels. In conclusion, decreased risk of NEC is observed with probiotics, antenatal corticosteroids for women at risk of preterm birth, and ibuprofen versus indomethacin for treatment of PDA. Targeting lower oxygen saturations may increase the risk of surgical NEC, compared to targeting higher saturations.
DOI: 10.6084/m9.figshare.11364905
title: Data.zip

description: The Surveillance, Epidemiology, and End Results (SEER) public-use data set frThe Surveillance, Epidemiology, and End Results (SEER) public-use data set from 1975 to 2016 was analyzed to determine incidence trends for MBC. We compared overall survival (OS) and breast cancer specific survival (BCSS) using Kaplan–Meier analysis and the multivariate Cox proportional model between groups for MBC women diagnosed from 2001 to 2016. Nomogram was performed to predict prognosis.om 1975 to 2016 was analyzed to determine incidence trends for MBC. We compared overall survival (OS) and breast cancer specific survival (BCSS) using Kaplan–Meier analysis and the multivariate Cox proportional model between groups for MBC women diagnosed from 2001 to 2016. Nomogram was performed to predict prognosis.
DOI: 10.6084/m9.figshare.11364896
title: Supplementary Material for: Synergistic Ototoxicity of Gentamicin and Low-Dose Irradiation: Molecular Basis and Clinical Significance

description: <b><i>Background:</i></b> Inner ear structures may be included in the radiation fields when irradiation is used to treat patients with head and neck cancers. These patients may also have concurrent infections that require gentamicin treatment. Radiation and gentamicin are both potentially ototoxic, and their combined use has been shown to result in synergistic ototoxicity in animals. <b><i>Objective:</i></b> We aimed to confirm the synergistic ototoxicity of combined gentamicin and low-dose irradiation treatment and identify the underlying molecular mechanisms using an in vitro model. <b><i>Method:</i></b> We compared the ototoxic effects of gentamicin, low-dose irradiation, and their combination in the OC-k3 mouse cochlear cell line using cell viability assay, live/dead stain, apoptosis detection assay, oxidative stress detection, and studied the molecular mechanisms involved using immunoblot analysis. <b><i>Results:</i></b> Combined treatment led to prolonged oxidative stress, reduced cell viability, and synergistic apoptosis. Gentamicin induced the concurrent accumulation of LC3b-II and SQSTM1/p62, suggesting an impairment of autophagic flux. Low-dose irradiation induced transient p53 phosphorylation and persistent Akt phosphorylation in response to DNA damage. In combined treatment, gentamicin attenuated irradiation-induced Akt activation. <b><i>Conclusions:</i></b> Besides increased oxidative stress, synergistic apoptosis observed in combined treatment could be attributed to gentamicin-induced perturbation of autophagic flux and attenuation of Akt phosphorylation, which led to an impairment of radiation-induced DNA repair response.
DOI: 10.6084/m9.figshare.11364905.v1
title: Data.zip

description: The Surveillance, Epidemiology, and End Results (SEER) public-use data set frThe Surveillance, Epidemiology, and End Results (SEER) public-use data set from 1975 to 2016 was analyzed to determine incidence trends for MBC. We compared overall survival (OS) and breast cancer specific survival (BCSS) using Kaplan–Meier analysis and the multivariate Cox proportional model between groups for MBC women diagnosed from 2001 to 2016. Nomogram was performed to predict prognosis.om 1975 to 2016 was analyzed to determine incidence trends for MBC. We compared overall survival (OS) and breast cancer specific survival (BCSS) using Kaplan–Meier analysis and the multivariate Cox proportional model between groups for MBC women diagnosed from 2001 to 2016. Nomogram was performed to predict prognosis.
DOI: 10.6084/m9.figshare.11364827
title: Supplementary Material for: Comparison of ABC Methods with Computerized Estimates of Intracerebral Hemorrhage Volume: The INTERACT2 Study

description: <b><i>Background and Purpose:</i></b> Hematoma volume is a key determinant of outcome in acute intracerebral hemorrhage (ICH). We aimed to compare estimates of ICH volume between simple (ABC/2, length, width, and height) and gold standard planimetric software approaches. <b><i>Methods:</i></b> Data are from the second Intensive Blood Pressure Reduction in Acute Cerebral Hemorrhage Trial (INTERACT2). Multivariable linear regression was used to compare ICH volumes on baseline CT scans using the ABC/2, modified ABC/2 (mABC/2), and MIStar software. Other aspects of ICH morphology examined included location, irregularity, heterogeneity, intraventricular and subarachnoid hemorrhage extension (SAH) of hematoma, and associated white matter lesions and brain atrophy.<b><i> Results:</i></b> In 2,084 patients with manual and semiautomated measurements, median (IQR) ICH volumes for each approach were: ABC/2 11.1 (5.11–20.88 mL), mABC/2 7.8 (3.88–14.11 mL), and MIStar 10.7 (5.59–18.66 mL). Median differences between ABC/2 and MIStar, and mABC/2 and MIStar were 0.34 (–1.01 to 2.96) and –2.4 (–4.95 to –0.7416), respectively. Hematoma volumes differed significantly with irregular shape (ABC/2 and MIStar, <i>p</i> &lt; 0.001; mABC/2 and MIStar, <i>p</i> = 0.007) and larger volumes (mABC/2 and MIStar, <i>p</i> &lt; 0.001; ABC/2 and MIStar, <i>p</i> = 0.07). ICH with SAH showed a significant discrepancy between ABC/2 and MIStar (<i>p</i> &lt; 0.001).<b><i> Conclusions:</i></b> Overall, ABC/2 performs better than mABC/2 in estimating ICH volume. The largest discrepancies were evidenced against automated software for irregular-shaped and large ICH with SAH, but the clinical significance of this is uncertain.