cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.1613779
title: Cost-effectiveness analysis of oxycodone with naloxone versus oxycodone alone for the management of moderate-to-severe pain in patients with opioid-induced constipation in Canada

description: <b>Background:</b> Approximately 20–30% of Canadians suffer from chronic pain. Guidelines for the management of chronic pain support the use of controlled-release (CR) opioids to treat chronic pain. Although effective in managing chronic pain, oxycodone is associated with high rates of opioid-induced constipation (OIC). The cost-effectiveness of a combination of oxycodone for the management of pain and naloxone for the relief of OIC has not previously been evaluated for Canada. <b>Methods:</b> A decision analytic model was developed to estimate the cost-utility of combination oxycodone/naloxone compared to oxycodone alone in four populations. Drug costs for managing pain and healthcare costs related to managing OIC were included in the analysis and the primary measure of effectiveness was quality adjusted life years (QALYs) derived from OIC rates observed in clinical trials. The analysis was conducted from a healthcare system perspective, used a 1-year time horizon, and results were expressed in 2015 Canadian dollars. <b>Results:</b> In all four patient populations, there was a trade-off between slightly higher total expected costs for Targin treated patients compared to oxycodone treated patients, but also improved clinical benefits in terms of reduced OIC, which resulted in higher QALYs for patients. Although analgesic costs were found to be slightly higher for Targin treated patients, Targin also resulted in cost offsets to the healthcare system in terms of less rescue laxative drug use and other resources required for the management of OIC. The resulting 1-year cost-utility of Targin compared to oxycodone ranged from $2178–$7732 per QALY gained in the base case analysis, and it was found that these cost-utility results remained robust and at low values throughout a series of one-way deterministic analyses of uncertainty. <b>Conclusion:</b> The clinical effectiveness of oxycodone/naloxone in managing pain and OIC compared to CR oxycodone alone resulted in low cost-utility estimates.
DOI: 10.6084/m9.figshare.1613777
title: HMGB1 in bladder pain

description: Protease-Activated Receptor 4 Induces Bladder Pain through High Mobility Group Box-1
DOI: 10.6084/m9.figshare.1613779.v1
title: Cost-effectiveness analysis of oxycodone with naloxone versus oxycodone alone for the management of moderate-to-severe pain in patients with opioid-induced constipation in Canada

description: <b>Background:</b> Approximately 20–30% of Canadians suffer from chronic pain. Guidelines for the management of chronic pain support the use of controlled-release (CR) opioids to treat chronic pain. Although effective in managing chronic pain, oxycodone is associated with high rates of opioid-induced constipation (OIC). The cost-effectiveness of a combination of oxycodone for the management of pain and naloxone for the relief of OIC has not previously been evaluated for Canada. <b>Methods:</b> A decision analytic model was developed to estimate the cost-utility of combination oxycodone/naloxone compared to oxycodone alone in four populations. Drug costs for managing pain and healthcare costs related to managing OIC were included in the analysis and the primary measure of effectiveness was quality adjusted life years (QALYs) derived from OIC rates observed in clinical trials. The analysis was conducted from a healthcare system perspective, used a 1-year time horizon, and results were expressed in 2015 Canadian dollars. <b>Results:</b> In all four patient populations, there was a trade-off between slightly higher total expected costs for Targin treated patients compared to oxycodone treated patients, but also improved clinical benefits in terms of reduced OIC, which resulted in higher QALYs for patients. Although analgesic costs were found to be slightly higher for Targin treated patients, Targin also resulted in cost offsets to the healthcare system in terms of less rescue laxative drug use and other resources required for the management of OIC. The resulting 1-year cost-utility of Targin compared to oxycodone ranged from $2178–$7732 per QALY gained in the base case analysis, and it was found that these cost-utility results remained robust and at low values throughout a series of one-way deterministic analyses of uncertainty. <b>Conclusion:</b> The clinical effectiveness of oxycodone/naloxone in managing pain and OIC compared to CR oxycodone alone resulted in low cost-utility estimates.
DOI: 10.6084/m9.figshare.1613777.v1
title: HMGB1 in bladder pain

description: Protease-Activated Receptor 4 Induces Bladder Pain through High Mobility Group Box-1
DOI: 10.6084/m9.figshare.1613788.v1
title: Calanus Euxinus size measurements

description: Prosome lenght, total length, lateral width and dorsal width of the C.euxinus specimens used in acoustic estimations
DOI: 10.6084/m9.figshare.1613788.v2
title: Calanus Euxinus size measurements

description: Prosome lenght, total length, lateral width and dorsal width of the C.euxinus specimens used in acoustic estimations
DOI: 10.6084/m9.figshare.1613788.v4
title: Calanus Euxinus size measurements

description: Prosome lenght, total length, lateral width and dorsal width of the C.euxinus specimens used in acoustic estimations. Each rar file contains measurements from different stations. Stations information is writtine in a text file within the rar file.
DOI: 10.6084/m9.figshare.1613545
title: O Intervencionismo da ONU

description: A reconstrução de estados pós-conflito (seja este intra-estatal ou interestatal), remeto-nos invariavelmente para uma autoridade neutra, internacional e universal que permita, por um lado mediar conflitos com base num direito internacional sólido e institucionalizado e por outro possibilitar a ajuda humanitária para que esta reconstrução seja levada a cabo. No Período pós-Guerra Fria, a ONU foi a organização que mais assumiu um papel interventivo. O seu papel tem sido analizado histórica e éticamente. Neste breve ensaio pretendo reunir algumas visões acerca do intervencionismo da ONU com base na bibliografia sugerida.
DOI: 10.6084/m9.figshare.1613545.v1
title: O Intervencionismo da ONU

description: A reconstrução de estados pós-conflito (seja este intra-estatal ou interestatal), remeto-nos invariavelmente para uma autoridade neutra, internacional e universal que permita, por um lado mediar conflitos com base num direito internacional sólido e institucionalizado e por outro possibilitar a ajuda humanitária para que esta reconstrução seja levada a cabo. No Período pós-Guerra Fria, a ONU foi a organização que mais assumiu um papel interventivo. O seu papel tem sido analizado histórica e éticamente. Neste breve ensaio pretendo reunir algumas visões acerca do intervencionismo da ONU com base na bibliografia sugerida.
DOI: 10.6084/m9.figshare.1613788.v3
title: Calanus Euxinus size measurements

description: Prosome lenght, total length, lateral width and dorsal width of the C.euxinus specimens used in acoustic estimations
DOI: 10.6084/m9.figshare.1613542
title: Circulating RNA: looking at the liver through a frosted glass

description: <i>Context</i>: The evaluation of the liver condition, based on serum enzymatic activity and biopsies, is insufficient. Therefore, it is a priority to find a correlation between circulating RNAs and liver damage. <i>Methods</i>: Publications were retrieved by the search terms “circulating RNA AND liver”. <i>Results</i>: Although differences exist between studies, a profile of RNAs that repeatedly appeared as indicators of liver damage was identified. <i>Discussion</i>: We highlight those circulating RNAs useful to diagnostic, and discuss the transport mechanisms. <i>Conclusion</i>: Several studies have proven that circulating RNAs are useful to establish a diagnostic and a prognosis of liver diseases.
DOI: 10.6084/m9.figshare.1613543
title: Effect of genetic and environmental factors on protein biomarkers for common non-communicable disease and use of personally normalized plasma protein profiles (PNPPP)

description: <i>Objective</i>: To study the impact of genetic and lifestyle factors on protein biomarkers and develop <i>personally normalized plasma protein profiles</i> (PNPPP) controlling for non-disease-related variance. <i>Materials and methods</i>: Proximity extension assays were used to measure 145 proteins in 632 controls and 344 cases with non-communicable diseases. <i>Results</i>: Genetic and lifestyle factors explained 20–88% of the variation in healthy controls. Adjusting for these factors reduced the number of candidate biomarkers by 63%. <i>Conclusion</i>: PNPPP efficiently controls for non-disease-related variance, allowing both for efficient discovery of novel biomarkers and for covariate-independent linear cut-offs suitable for clinical use.
DOI: 10.6084/m9.figshare.1613536
title: Additional materials: Organs-on-chips in Drug Development: The Importance of Involving Stakeholders in Early Health Technology Assessment

description: The framework of the study as well as the survey that was send to all stakeholders.
DOI: 10.6084/m9.figshare.1613542.v2
title: Circulating RNA: looking at the liver through a frosted glass

description: <i>Context</i>: The evaluation of the liver condition, based on serum enzymatic activity and biopsies, is insufficient. Therefore, it is a priority to find a correlation between circulating RNAs and liver damage. <i>Methods</i>: Publications were retrieved by the search terms “circulating RNA AND liver”. <i>Results</i>: Although differences exist between studies, a profile of RNAs that repeatedly appeared as indicators of liver damage was identified. <i>Discussion</i>: We highlight those circulating RNAs useful to diagnostic, and discuss the transport mechanisms. <i>Conclusion</i>: Several studies have proven that circulating RNAs are useful to establish a diagnostic and a prognosis of liver diseases.
DOI: 10.6084/m9.figshare.1613542.v1
title: Circulating RNA: looking at the liver through a frosted glass

description: <i>Context</i>: The evaluation of the liver condition, based on serum enzymatic activity and biopsies, is insufficient. Therefore, it is a priority to find a correlation between circulating RNAs and liver damage.<i>Methods</i>: Publications were retrieved by the search terms “circulating RNA AND liver”.<i>Results</i>: Although differences exist between studies, a profile of RNAs that repeatedly appeared as indicators of liver damage was identified.<i>Discussion</i>: We highlight those circulating RNAs useful to diagnostic, and discuss the transport mechanisms.<i>Conclusion</i>: Several studies have proven that circulating RNAs are useful to establish a diagnostic and a prognosis of liver diseases.
DOI: 10.6084/m9.figshare.1613543.v2
title: Effect of genetic and environmental factors on protein biomarkers for common non-communicable disease and use of personally normalized plasma protein profiles (PNPPP)

description: <i>Objective</i>: To study the impact of genetic and lifestyle factors on protein biomarkers and develop <i>personally normalized plasma protein profiles</i> (PNPPP) controlling for non-disease-related variance. <i>Materials and methods</i>: Proximity extension assays were used to measure 145 proteins in 632 controls and 344 cases with non-communicable diseases. <i>Results</i>: Genetic and lifestyle factors explained 20–88% of the variation in healthy controls. Adjusting for these factors reduced the number of candidate biomarkers by 63%. <i>Conclusion</i>: PNPPP efficiently controls for non-disease-related variance, allowing both for efficient discovery of novel biomarkers and for covariate-independent linear cut-offs suitable for clinical use.
DOI: 10.6084/m9.figshare.1613535
title: Organs-on-chips in Drug Development: The Importance of Involving Stakeholders in Early Health Technology Assessment

description: The survey that was send to the stakeholders to obtain information about the possible implementation of organs-on-chips in the drug development process.
DOI: 10.6084/m9.figshare.1613536.v1
title: Organs-on-chips in Drug Development: The Importance of Involving Stakeholders in Early Health Technology Assessment

description: The framework of the study as well as the survey that was send to all stakeholders.
DOI: 10.6084/m9.figshare.1613543.v1
title: Effect of genetic and environmental factors on protein biomarkers for common non-communicable disease and use of personally normalized plasma protein profiles (PNPPP)

description: <i>Objective</i>: To study the impact of genetic and lifestyle factors on protein biomarkers and develop <i>personally normalized plasma protein profiles</i> (PNPPP) controlling for non-disease-related variance.<i>Materials and methods</i>: Proximity extension assays were used to measure 145 proteins in 632 controls and 344 cases with non-communicable diseases.<i>Results</i>: Genetic and lifestyle factors explained 20–88% of the variation in healthy controls. Adjusting for these factors reduced the number of candidate biomarkers by 63%.<i>Conclusion</i>: PNPPP efficiently controls for non-disease-related variance, allowing both for efficient discovery of novel biomarkers and for covariate-independent linear cut-offs suitable for clinical use.
DOI: 10.6084/m9.figshare.1613535.v1
title: Organs-on-chips in Drug Development: The Importance of Involving Stakeholders in Early Health Technology Assessment

description: The survey that was send to the stakeholders to obtain information about the possible implementation of organs-on-chips in the drug development process.
DOI: 10.6084/m9.figshare.1613536.v3
title: Additional materials: Organs-on-chips in Drug Development: The Importance of Involving Stakeholders in Early Health Technology Assessment

description: The framework of the study as well as the survey that was send to all stakeholders.
DOI: 10.6084/m9.figshare.1613536.v2
title: Additional materials: Organs-on-chips in Drug Development: The Importance of Involving Stakeholders in Early Health Technology Assessment

description: The framework of the study as well as the survey that was send to all stakeholders.
DOI: 10.6084/m9.figshare.1613504
title: 8 letter word list

description: List of 8 letter words for countdown game. See attached code<br>
DOI: 10.6084/m9.figshare.1613510
title: Factors influencing the discovery and use of wildlife passages for small fauna - Data and meta-data

description: Data used to extract passageway use and discovery information for 17 wildlife passages in Quebec, Canada. Data obtained with the funding of the Quebec Ministry of Transportation, awarded to Concordia University.<b><br></b>Published. Martinig, A. R., and K. Bélanger-Smith. 2016<i>. </i>Factors influencing the discovery and success of wildlife passages for smaller fauna. Journal of Applied Ecology 53:825–836.
DOI: 10.6084/m9.figshare.1613500
title: The power of long term monitoring, 15 years and counting #AOC15

description: Mount Lofty Ranges Woodland Bird Monitoring Program and research findings so far.
DOI: 10.6084/m9.figshare.1613500.v1
title: The power of long term monitoring, 15 years and counting #AOC15

description: Mount Lofty Ranges Woodland Bird Monitoring Program and research findings so far.
DOI: 10.6084/m9.figshare.1613510.v3
title: Factors influencing the discovery and use of wildlife passages for small fauna - Data and meta-data

description: Data used to extract passageway use and discovery information for 17 wildlife passages in Quebec, Canada. Data obtained with the funding of the Quebec Ministry of Transportation, awarded to Concordia University.<b><br></b>Published. Martinig, A. R., and K. Bélanger-Smith. 2016<i>. </i>Factors influencing the discovery and success of wildlife passages for smaller fauna. Journal of Applied Ecology 53:825–836.
DOI: 10.6084/m9.figshare.1613478
title: Cutaneous Leishmaniasis in Libya

description: Cutaneous leishmaniasis ranks among the tropical diseases least known and most neglected in Libya. World Health Organization reports recognized associations of <i>Phlebotomus papatasi</i>, <i>Psammomys</i> <i>obesus</i>, and <i>Meriones </i>spp., with transmission of zoonotic cutaneous leishmaniasis (ZCL; caused by <i>Leishmania major</i>) across Libya. This data set represent occurrence records of six species associated with the transmission cycle in the country.
DOI: 10.6084/m9.figshare.1613510.v5
title: Factors influencing the discovery and use of wildlife passages for small fauna - Data and meta-data

description: Data used to extract passageway use and discovery information for 17 wildlife passages in Quebec, Canada. Data obtained with the funding of the Quebec Ministry of Transportation, awarded to Concordia University.<b><br></b>Published. Martinig, A. R., and K. Bélanger-Smith. 2016<i>. </i>Factors influencing the discovery and success of wildlife passages for smaller fauna. Journal of Applied Ecology 53:825–836.
DOI: 10.6084/m9.figshare.1613510.v4
title: Factors influencing the discovery and use of wildlife passages for small fauna - Data and meta-data

description: Data used to extract passageway use and discovery information for 17 wildlife passages in Quebec, Canada. Data obtained with the funding of the Quebec Ministry of Transportation, awarded to Concordia University.<b><br></b>Published. Martinig, A. R., and K. Bélanger-Smith. 2016<i>. </i>Factors influencing the discovery and success of wildlife passages for smaller fauna. Journal of Applied Ecology 53:825–836.
DOI: 10.6084/m9.figshare.1613459
title: The acoustic world of fish: Sound ways to investigate migratory bottlenecks

description: Many fish species migrate through<br>freshwater river systems related to seasonal<br>or life cycle changes in habitat requirements.
DOI: 10.6084/m9.figshare.1613437
title: Gaussian Job Archive for C8H13ClN2O4

description: Archive of work produced using the resources of the Imperial College High Performance Computing Service.
DOI: 10.6084/m9.figshare.1613452
title: data for kinesin motor simulation

description: Here are the program and the datas for simulations of kinesin motors and nanoparticle proceeding on microtubule.
DOI: 10.6084/m9.figshare.1613442
title: Gaussian Job Archive for C8H13ClN2O4

description: Archive of work produced using the resources of the Imperial College High Performance Computing Service.
DOI: 10.6084/m9.figshare.1613436
title: Gaussian Job Archive for C8H13ClN2O4

description: Archive of work produced using the resources of the Imperial College High Performance Computing Service.
DOI: 10.6084/m9.figshare.1613437.v1
title: Gaussian Job Archive for C8H13ClN2O4

description: Archive of work produced using the resources of the Imperial College High Performance Computing Service.
DOI: 10.6084/m9.figshare.1613442.v1
title: Gaussian Job Archive for C8H13ClN2O4

description: Archive of work produced using the resources of the Imperial College High Performance Computing Service.
DOI: 10.6084/m9.figshare.1613452.v1
title: data for kinesin motor simulation

description: Here are the program and the datas for simulations of kinesin motors and nanoparticle proceeding on microtubule.
DOI: 10.6084/m9.figshare.1613434
title: 研究データの発信に向けて : 「ホームページによる情報発信」の次を考える

description: 専門図書館協議会全国研究集会<br>第5分科会「オープンサイエンスと研究データ公開」 発表「研究データの発信に向けて : 「ホームページによる情報発信」の次を考える 」の当日資料
DOI: 10.6084/m9.figshare.1613431
title: Cross reactivity of S. aureus to murine cytokine assays: A source of discrepancy

description: Staphylococcus aureus is one of the versatile Gram positive bacteria causing a range of diseases. Upon challenge, host immune cells recognize S. aureus and mount diverse immune responses including production of pro-inflammatory cytokines such as IL-1β and TNF-α. These cytokines are important mediators of inflammation which can be detected via various immunological methods such as enzyme linked immunosorbent assay (ELISA). In the current study, we found that a number of clinical isolates as well as laboratory strains of S. aureus exhibited cross reactivity with ELISA antibodies for murine IL-1β and TNF-α assays. This cross reactivity generates exaggerated false positive signals which can be a source of discrepancy for the understanding of real immune responses against S. aureus infection by host immune cells.
DOI: 10.6084/m9.figshare.1613434.v1
title: 研究データの発信に向けて : 「ホームページによる情報発信」の次を考える

description: 専門図書館協議会全国研究集会<br>第5分科会「オープンサイエンスと研究データ公開」 発表「研究データの発信に向けて : 「ホームページによる情報発信」の次を考える 」の当日資料
DOI: 10.6084/m9.figshare.1613431.v1
title: Cross reactivity of S. aureus to murine cytokine assays: A source of discrepancy

description: Staphylococcus aureus is one of the versatile Gram positive bacteria causing a range of diseases. Upon challenge, host immune cells recognize S. aureus and mount diverse immune responses including production of pro-inflammatory cytokines such as IL-1β and TNF-α. These cytokines are important mediators of inflammation which can be detected via various immunological methods such as enzyme linked immunosorbent assay (ELISA). In the current study, we found that a number of clinical isolates as well as laboratory strains of S. aureus exhibited cross reactivity with ELISA antibodies for murine IL-1β and TNF-α assays. This cross reactivity generates exaggerated false positive signals which can be a source of discrepancy for the understanding of real immune responses against S. aureus infection by host immune cells.
DOI: 10.6084/m9.figshare.1613411
title: Dataset: No effect of steady rotation on solid 4He in a torsional oscillator

description: Data published in "No Effect of Steady Rotation on Solid 4He in a Torsional Oscillator", M.J. Fear et al., Journal of Low Temperature Physics.
DOI: 10.6084/m9.figshare.1613413
title: The supplementation of branched-chain amino acids, arginine, and citrulline improve endurance exercise performance in two consecutive days

description: The effects of branched-chain amino acids, arginine, and citrulline on 5000 m and 10000 m time-trial in 2 consecutive days, including time-trial results and blood biochemical analysis.
DOI: 10.6084/m9.figshare.1613408
title: Cambodia HTA-Diabetes household survey - ATM RPC551

description: Household survey exploring diagnostic and treatment pathways for people living with diabetes and hypertension in rural Cambodia.
DOI: 10.6084/m9.figshare.1613411.v1
title: Dataset: No effect of steady rotation on solid 4He in a torsional oscillator

description: Data published in "No Effect of Steady Rotation on Solid 4He in a Torsional Oscillator", M.J. Fear et al., Journal of Low Temperature Physics.
DOI: 10.6084/m9.figshare.1613408.v1
title: Cambodia HTA-Diabetes household survey - ATM RPC551

description: Household survey exploring diagnostic and treatment pathways for people living with diabetes and hypertension in rural Cambodia.
DOI: 10.6084/m9.figshare.1613398
title: Dynamics of Escherichia coli type I-E CRISPR spacers

description: E coli typeI-E and Salmonella I-E spacer datasets<br>E.coli type I-E CRISPR spacers obtained by Illumina seq from mammoth hostreconstructed array fragments<br>
DOI: 10.6084/m9.figshare.1613387
title: Data for paper --Collapse of corroded pipelines under combined tension and external pressure

description: The data presented here is corresponding to the paper titled "Collapse of corroded pipelines under combined tension and external pressure"
DOI: 10.6084/m9.figshare.1613398.v1
title: SI Savitskaya et al

description: E.coli type I-E CRISPR spacers obtained by Illumina seq
DOI: 10.6084/m9.figshare.1613387.v2
title: Data for paper --Collapse of corroded pipelines under combined tension and external pressure

description: The data presented here is corresponding to the paper titled "Collapse of corroded pipelines under combined tension and external pressure"
DOI: 10.6084/m9.figshare.1613398.v2
title: Savitskaya et al

description: E.coli type I-E CRISPR spacers obtained by Illumina seq