cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.8848226
title: Inhibitory effect of liposomal quercetin on acute hepatitis and hepatic fibrosis induced by concanavalin A

description: Immune response plays an important role in the development of hepatic fibrosis. In the present study, we investigated the effects of quercetin on hepatitis and hepatic fibrosis induced by immunological mechanism. In the acute hepatitis model, quercetin (2.5 mg/kg) was injected iv into mice 30 min after concanavalin A (Con A) challenge. Mice were sacrificed 4 or 24 h after Con A injection, and aminotransferase tests and histopathological sections were performed. Treatment with quercetin significantly decreased the levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST). Consistent with this observation, treatment with quercetin markedly attenuated the pathologic changes in the liver. A hepatic fibrosis model was also generated in mice by Con A challenge once a week for 6 consecutive weeks. Mice in the experimental group were treated with daily iv injections of quercetin (0.5 mg/kg). Histopathological analyses revealed that treatment with quercetin markedly decreased collagen deposition, pseudolobuli development, and hepatic stellate cells activation. We also examined the effects of quercetin on the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) and transforming growth factor beta (TGF-β) pathways by immunohistochemistry and real-time reverse transcriptase-polymerase chain reaction (RT-PCR). NF-κB and TGF-β production was decreased after treatment with quercetin, indicating that the antifibrotic effect of quercetin is associated with its ability to modulate NF-κB and TGF-β production. These results suggest that quercetin may be an effective therapeutic strategy in the treatment of patients with liver damage and fibrosis.
DOI: 10.6084/m9.figshare.8848229.v1
title: Some physico-chemical properties, fatty acid compositions, macro-micro minerals and sterol contents of two variety tigernut tubers and oils harvested from East Mediterranean region

description: Abstract This research on Yellow sugar and Honey tuber varieties tigernut tubers’ oils physico-chemical properties were investigated to collected from Adana province in Turkey. The 1000 seed weight, width, length, moisture, ash and ascorbic acid values of yellow sugar and honey wax tubers were established as 343,496 and 327,524 g, 7.61 and 8.76 mm, 17.07 and 15.23 mm, 6.41 and 6.45%, 1.19 and 1.38% and 67.34 and 58.81 mg/kg, respectively. Free fatty acidity, peroxide values, refractive index, density, iodine number, total sterol, saponifiable matter, unsaponifiable matter, mineral values of yellow sugar and honey tuber tigernut oils were determined. The palmitic, stearic, oleic and linoleic acid contents of yellow sugar and honey tuber oils were determined as 13.02 and 12.76, 3.92 and 3.94, 69.34 and 69.91, and 11.93 and 11.80%, respectively. Campesterol, sitigmasterol and β-sitosterol contents of yellow sugar and honey tuber tigernut oils were determined. According to results, chufa tubers have high oil, oleic acid, sterol and some minerals suggest that these tubers may be very useful effect on human health and tuber oils can be use in the vegatable oil industry.
DOI: 10.6084/m9.figshare.8848220
title: Effects of exercise on cations/anions in blood serum of English Thoroughbred horses

description: ABSTRACT English Thoroughbred horses, are widespread in Mexico and due to the lack of data on their exercise physiology, it is important to conduct exercise tests in order to obtain information the effects of exercise on more essential cations/anions in blood serum, as these horses are submitted to constant efforts. The study was carried out with 150 blood samples of English Thoroughbred horses clinically healthy. The blood sample collection was performed during three periods: 1) rest, 2) 30min after exercise (speed race of 12km/h for 30min with no rest) and 3) 60min after exercise. Mean values were calculated for cations (sodium and potassium) and anions (chloride and bicarbonate). The resulting data set was analyzed using Gaussian distribution and descriptive statistics. Confidence intervals of 95% were established. The linear relationships between ions were quantified, and an analysis of variance was performed to compare the mean values between groups. The concentrations of the described analytes are consistent with values reported by international literature. The comparison between groups, revealed that during exercise, sodium ion did not show changes 30min after exercise and increase 60min after. Potassium ion showed increase 30min after exercise and decrease 60min after. Chloride ion showed a decrease 30min after exercise, to recover gradually 60min after. Meanwhile, bicarbonate ion showed increase 30min after exercise, decreasing slightly in the final stage. Negative correlation between bicarbonate ion and chloride ion were determined. It was concluded that exercise tests are useful for the determination of acid-base balance and osmotic balance, and their main role is to evaluate the athletic ability of horses.Considering that chloride ion excretion and metabolic adjustments of potassium ion and bicarbonate ion are superior to water loss, compared to the normal osmolarity of blood serum. The results found can be used to structure an adequate replacement program of electrolytes lost in sweat.
DOI: 10.6084/m9.figshare.8848223.v1
title: THE TEACHING OF SPEECH THERAPY IN BRAZIL: A PORTRAIT OF THE UNDERGRADUATE COURSES

description: Abstract The present study was conducted in September 2018, and had the goal of checking the current state of the teaching of speech therapy in Brazil through a characterization of its undergraduate courses. In order to do so, a documentary and descriptive research was conducted with a quantitative and qualitative approach. Data collection was made through the website of the Brazilian Ministry of Education. We analyzed 87 speech therapy undergraduate courses linked to public (27.6%) and private (72.4%) higher education institutions, totaling 7,044 slots offered annually, with an average of 3,681 credit hours, and a period of integralization ranging from eight to ten semesters. The courses were distributed among 23 Brazilian states, with a higher concentration in the Southern region of the country. Most courses were graded 3 regarding the indicators of quality proposed by the Ministry of Education. We concluded that the teaching of speech therapy in Brazil is fundamentally in-person, private, distributed throughout the country, with a low rate of students taking the slots, an aspect deduced by the small number of graduates compared with the amount of slots offered, higher credit hours in the public higher education institutions, concluded between eight and ten semesters, and it presents satisfactory quality indicators.
DOI: 10.6084/m9.figshare.8848226.v1
title: Inhibitory effect of liposomal quercetin on acute hepatitis and hepatic fibrosis induced by concanavalin A

description: Immune response plays an important role in the development of hepatic fibrosis. In the present study, we investigated the effects of quercetin on hepatitis and hepatic fibrosis induced by immunological mechanism. In the acute hepatitis model, quercetin (2.5 mg/kg) was injected iv into mice 30 min after concanavalin A (Con A) challenge. Mice were sacrificed 4 or 24 h after Con A injection, and aminotransferase tests and histopathological sections were performed. Treatment with quercetin significantly decreased the levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST). Consistent with this observation, treatment with quercetin markedly attenuated the pathologic changes in the liver. A hepatic fibrosis model was also generated in mice by Con A challenge once a week for 6 consecutive weeks. Mice in the experimental group were treated with daily iv injections of quercetin (0.5 mg/kg). Histopathological analyses revealed that treatment with quercetin markedly decreased collagen deposition, pseudolobuli development, and hepatic stellate cells activation. We also examined the effects of quercetin on the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) and transforming growth factor beta (TGF-β) pathways by immunohistochemistry and real-time reverse transcriptase-polymerase chain reaction (RT-PCR). NF-κB and TGF-β production was decreased after treatment with quercetin, indicating that the antifibrotic effect of quercetin is associated with its ability to modulate NF-κB and TGF-β production. These results suggest that quercetin may be an effective therapeutic strategy in the treatment of patients with liver damage and fibrosis.
DOI: 10.6084/m9.figshare.8848217
title: MULTIPROFESSIONAL RESIDENCY IN HEALTH: ANALYSIS OF THE IMPLEMENTATION OF TWO PROGRAMS BY THE UNIVERSIDADE FEDERAL DE SANTA CATARINA, BRAZIL

description: Abstract The multiprofessional residencies in health meet the needs of the Brazilian Unified Health System and of the Ongoing Education Policy, and are a tool for the training and insertion of professionals in the health services. Due to the fact that it is a new intervention, we proposed an analysis to assess the degree of implementation of the program in two health care services connected to the Universidade Federal de Santa Catarina, with a documentary analysis and bibliographic reviews, with the development of the logical and theoretical models, and of the analysis and assessment matrix. The data collection, which took place between May and August 2018, was made through interviews with 16 actors from the program. The results of the assessment show favorable aspects regarding the organization of the political pedagogical process, the structuring of the follow-up agencies provided in the legislation, and the development of the selection process. As limiting aspects, we can mention the absence of financial resources to implement the activities of the residency students, low insertion of the tutors and preceptors in the learning process, few training initiatives for the actors, as well as absence of an evaluation by the National Committee of Multiprofessional Residencies in Health.
DOI: 10.6084/m9.figshare.8848220.v1
title: Effects of exercise on cations/anions in blood serum of English Thoroughbred horses

description: ABSTRACT English Thoroughbred horses, are widespread in Mexico and due to the lack of data on their exercise physiology, it is important to conduct exercise tests in order to obtain information the effects of exercise on more essential cations/anions in blood serum, as these horses are submitted to constant efforts. The study was carried out with 150 blood samples of English Thoroughbred horses clinically healthy. The blood sample collection was performed during three periods: 1) rest, 2) 30min after exercise (speed race of 12km/h for 30min with no rest) and 3) 60min after exercise. Mean values were calculated for cations (sodium and potassium) and anions (chloride and bicarbonate). The resulting data set was analyzed using Gaussian distribution and descriptive statistics. Confidence intervals of 95% were established. The linear relationships between ions were quantified, and an analysis of variance was performed to compare the mean values between groups. The concentrations of the described analytes are consistent with values reported by international literature. The comparison between groups, revealed that during exercise, sodium ion did not show changes 30min after exercise and increase 60min after. Potassium ion showed increase 30min after exercise and decrease 60min after. Chloride ion showed a decrease 30min after exercise, to recover gradually 60min after. Meanwhile, bicarbonate ion showed increase 30min after exercise, decreasing slightly in the final stage. Negative correlation between bicarbonate ion and chloride ion were determined. It was concluded that exercise tests are useful for the determination of acid-base balance and osmotic balance, and their main role is to evaluate the athletic ability of horses.Considering that chloride ion excretion and metabolic adjustments of potassium ion and bicarbonate ion are superior to water loss, compared to the normal osmolarity of blood serum. The results found can be used to structure an adequate replacement program of electrolytes lost in sweat.
DOI: 10.6084/m9.figshare.8848217.v1
title: MULTIPROFESSIONAL RESIDENCY IN HEALTH: ANALYSIS OF THE IMPLEMENTATION OF TWO PROGRAMS BY THE UNIVERSIDADE FEDERAL DE SANTA CATARINA, BRAZIL

description: Abstract The multiprofessional residencies in health meet the needs of the Brazilian Unified Health System and of the Ongoing Education Policy, and are a tool for the training and insertion of professionals in the health services. Due to the fact that it is a new intervention, we proposed an analysis to assess the degree of implementation of the program in two health care services connected to the Universidade Federal de Santa Catarina, with a documentary analysis and bibliographic reviews, with the development of the logical and theoretical models, and of the analysis and assessment matrix. The data collection, which took place between May and August 2018, was made through interviews with 16 actors from the program. The results of the assessment show favorable aspects regarding the organization of the political pedagogical process, the structuring of the follow-up agencies provided in the legislation, and the development of the selection process. As limiting aspects, we can mention the absence of financial resources to implement the activities of the residency students, low insertion of the tutors and preceptors in the learning process, few training initiatives for the actors, as well as absence of an evaluation by the National Committee of Multiprofessional Residencies in Health.
DOI: 10.6084/m9.figshare.8848205
title: Cassava biopolymer polyamide hydrogel accelerates healing of induced skin woundsin rats

description: ABSTRACT This study aimed to macroscopically and microscopically evaluate the healing of skin wounds induced in rats by topical application of cassava polyamide biopolymer hydrogel. In total, 32 rats were used and divided into four groups (n= 8): negative control - saline solution; positive control - use of commercial ointment; experimental group - I - ointment + cassava hydrogel; experimental group - II - cassava hydrogel. A 1cm2 wound induced on the animals dorsum was treated and evaluated. At day 21 post-operation, the animals were sacrificed by anesthetic overdose, and then 1cm2 of cicatricial skin from the wound region was collected. The material was cut to evaluate healing. In the macroscopic evaluation, complete healing was observed at the end of 21 days. Re-epithelialization was observed histologically; the connective tissue in the negative control, positive, and experimental - I groups was characterized by an abundance of collagen fibers, fibroblasts, and blood vessels. In experimental group - II additional healing was observed, as evidenced by the arrangement of collagen fibers and fibroblasts, and the reduction of neoformed vessels. Thus, we concluded that the hydrogel can assist in healing skin wounds, especially in the remodeling phase.
DOI: 10.6084/m9.figshare.8848205.v1
title: Cassava biopolymer polyamide hydrogel accelerates healing of induced skin woundsin rats

description: ABSTRACT This study aimed to macroscopically and microscopically evaluate the healing of skin wounds induced in rats by topical application of cassava polyamide biopolymer hydrogel. In total, 32 rats were used and divided into four groups (n= 8): negative control - saline solution; positive control - use of commercial ointment; experimental group - I - ointment + cassava hydrogel; experimental group - II - cassava hydrogel. A 1cm2 wound induced on the animals dorsum was treated and evaluated. At day 21 post-operation, the animals were sacrificed by anesthetic overdose, and then 1cm2 of cicatricial skin from the wound region was collected. The material was cut to evaluate healing. In the macroscopic evaluation, complete healing was observed at the end of 21 days. Re-epithelialization was observed histologically; the connective tissue in the negative control, positive, and experimental - I groups was characterized by an abundance of collagen fibers, fibroblasts, and blood vessels. In experimental group - II additional healing was observed, as evidenced by the arrangement of collagen fibers and fibroblasts, and the reduction of neoformed vessels. Thus, we concluded that the hydrogel can assist in healing skin wounds, especially in the remodeling phase.
DOI: 10.6084/m9.figshare.8848196
title: Performance and digestibility of confined lambs fed with Babassu cake (Orbignya speciosa) as a substitute for elephant grass silage

description: ABSTRACT The objective of this study was to evaluate the effect of the partial replacement of elephant grass silage with babassu (Orbignya speciosa) on the performance, intake, digestibility, and carcass weight gain of sheep. Fifty-four castrated male lambs (19.08±2.76kg) were distributed in a completely randomized design and administered one of the following treatments: 0.0, 12.5, 25.0, 37.5 or 50% dry matter (%DM) replacement of elephant grass silage with babassu cake. No difference (P&gt; 0.05) was observed in the dry matter, crude protein, and neutral detergent fiber intake, but the ether extract intake increased (P&lt; 0.05). The digestibility of the dry matter, neutral detergent fiber, and total digestible nutrients were unaffected. The crude protein digestibility decreased (P&lt; 0.05), and the ether extract digestibility increased with the replacement of the elephant grass. There were no changes in mean daily weight gain and carcass weight gain. In the carcasses, a linear increase was observed in the proportion of the ether extract, and the crude protein decreased. The replacement of the silage with the babassu cake by up to 50% did not change the performance of sheep, however it led to an increase in fat deposit in the carcass.
DOI: 10.6084/m9.figshare.8848193
title: The role of Brazil in the International Commission for the Conservation of Atlantic Tunas (ICCAT)

description: Abstract Although Brazil has been an active voice in ICCAT in the past ten years, its leadership has been declining. This paper examines what might explain the variation of international influence Brazil has had in addressing the issues at ICCAT and argues that if Brazil wants to preserve its leadership, it must demonstrate commitment to its own waters while strengthening governmental institutions.
DOI: 10.6084/m9.figshare.8848196.v1
title: Performance and digestibility of confined lambs fed with Babassu cake (Orbignya speciosa) as a substitute for elephant grass silage

description: ABSTRACT The objective of this study was to evaluate the effect of the partial replacement of elephant grass silage with babassu (Orbignya speciosa) on the performance, intake, digestibility, and carcass weight gain of sheep. Fifty-four castrated male lambs (19.08±2.76kg) were distributed in a completely randomized design and administered one of the following treatments: 0.0, 12.5, 25.0, 37.5 or 50% dry matter (%DM) replacement of elephant grass silage with babassu cake. No difference (P&gt; 0.05) was observed in the dry matter, crude protein, and neutral detergent fiber intake, but the ether extract intake increased (P&lt; 0.05). The digestibility of the dry matter, neutral detergent fiber, and total digestible nutrients were unaffected. The crude protein digestibility decreased (P&lt; 0.05), and the ether extract digestibility increased with the replacement of the elephant grass. There were no changes in mean daily weight gain and carcass weight gain. In the carcasses, a linear increase was observed in the proportion of the ether extract, and the crude protein decreased. The replacement of the silage with the babassu cake by up to 50% did not change the performance of sheep, however it led to an increase in fat deposit in the carcass.
DOI: 10.6084/m9.figshare.8848190
title: First description of basaloid carcinoma of the canine mammary gland: case report

description: ABSTRACT The objective of this case report was to describe histopathological and immunohistochemical characteristics of the first reported basaloid carcinomas in the canine mammary gland. Two bitches were treated for tumors in the mammary gland and underwent mastectomy. Microscopic evaluation of these tumors revealed epithelial cells arranged in a predominantly solid pattern with hyperchromatic peripheral cells arranged in a palisade pattern. Metastases in regional lymph nodes were found in both animals, and one bitch exhibited pulmonary metastasis. Immunohistochemistry revealed positive labeling for the basal cell markers cytokeratin 14 and p63. Histopathological and immunohistochemical findings led to diagnoses of basaloid carcinoma of the canine mammary gland with regional and distant metastasis.
DOI: 10.6084/m9.figshare.8848193.v1
title: The role of Brazil in the International Commission for the Conservation of Atlantic Tunas (ICCAT)

description: Abstract Although Brazil has been an active voice in ICCAT in the past ten years, its leadership has been declining. This paper examines what might explain the variation of international influence Brazil has had in addressing the issues at ICCAT and argues that if Brazil wants to preserve its leadership, it must demonstrate commitment to its own waters while strengthening governmental institutions.
DOI: 10.6084/m9.figshare.8848184
title: NEONATAL MORBIDITY NEAR MISS IN TERTIARY HOSPITALS IN A CAPITAL OF NORTHEAST BRAZIL

description: ABSTRACT Objective: To characterize near miss neonatal morbidity in tertiary hospitals in a capital city of Northeast Brazil based on Health Information Systems, and to identify differences regarding indicators of near miss cases, allowing the surveillance of newborns with risk of death. Methods: A cross-sectional study carried out in hospitals with neonatal intensive care unit, whose neonatal near miss cases in 2012 were identified from a deterministic linkage between the Mortality Information System and the Live Birth Information System. The biological variables of children, variables related to maternal characteristics and indicators of near miss were calculated by type of service and hospital. Biological variables of children, variables related to maternal characteristics and near miss indicators were calculated by service type and hospital and then compared by ratio difference test, parametric and non-parametric tests for measures of central tendency. Results: Of 24,254 live births, 2,098 cases of neonatal morbidity near miss were identified, most of them concentrated in the public hospitals (89.9%). The combination of birth weight and gestational age had the largest number of cases in both segments, public (43.5%) and private (46%). Variations in neonatal near miss indicators were observed between hospitals, which suggests assistance problems. Conclusions: The concept of neonatal near miss, its applicability with data from Health Information Systems, and its indicators are a preliminary tool to monitor hospital care for newborns by signaling health services that require in-depth evaluation and investments for quality improvement.