cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.5281/zenodo.7576336
title: Quantitative Assessment of Late Gadolinium Enhancement and Edema at Cardiac Magnetic Resonance in Low-Risk Myocarditis Patients

description: Monti CB, Secchi F, Alì M, Carbone FS, Bonomo L, Capra D, Mobini N, Di Leo G, Sardanelli F. Quantitative Assessment of Late Gadolinium Enhancement and Edema at Cardiac Magnetic Resonance in Low-Risk Myocarditis Patients. Tomography. 2022 Apr 1;8(2):974-984. doi: 10.3390/tomography8020078. PMID: 35448712; PMCID: PMC9028348. Abstract In this study, we aimed to quantify LGE and edema at short-tau inversion recovery sequences on cardiac magnetic resonance (CMR) in patients with myocarditis. We retrospectively evaluated CMR examinations performed during the acute phase and at follow-up. Forty-seven patients were eligible for retrospective LGE assessment, and, among them, twenty-five patients were eligible for edema evaluation. Both groups were paired with age- and sex-matched controls. The median left ventricle LGE was 6.4% (interquartile range 5.0-9.2%) at the acute phase, 4.4% (3.3-7.2%) at follow-up, and 4.3% (3.0-5.3%) in controls, the acute phase being higher than both follow-up and controls (<em>p &lt;</em> 0.001 for both), while follow-up and controls did not differ (<em>p =</em> 0.139). An optimal threshold of 5.0% was obtained for LGE with 87% sensitivity and 48% specificity; the positive likelihood ratio (LR) was 1.67, and the negative LR was 0.27. Edema was 12.8% (9.4-18.1%) at the acute phase, 7.3% (5.5-8.8%) at follow-up, and 6.7% (5.6-8.6%) in controls, the acute phase being higher than both follow-up and controls (both <em>p &lt;</em> 0.001), while follow-up and controls did not differ (<em>p =</em> 0.900). An optimal threshold of 9.5% was obtained for edema with a sensitivity of 76% and a specificity of 88%; the positive LR was 6.33, and the negative LR was 0.27. LGE and edema thresholds are useful in cases of suspected mild myocarditis.
DOI: 10.5281/zenodo.7576335
title: Quantitative Assessment of Late Gadolinium Enhancement and Edema at Cardiac Magnetic Resonance in Low-Risk Myocarditis Patients

description: Monti CB, Secchi F, Alì M, Carbone FS, Bonomo L, Capra D, Mobini N, Di Leo G, Sardanelli F. Quantitative Assessment of Late Gadolinium Enhancement and Edema at Cardiac Magnetic Resonance in Low-Risk Myocarditis Patients. Tomography. 2022 Apr 1;8(2):974-984. doi: 10.3390/tomography8020078. PMID: 35448712; PMCID: PMC9028348. Abstract In this study, we aimed to quantify LGE and edema at short-tau inversion recovery sequences on cardiac magnetic resonance (CMR) in patients with myocarditis. We retrospectively evaluated CMR examinations performed during the acute phase and at follow-up. Forty-seven patients were eligible for retrospective LGE assessment, and, among them, twenty-five patients were eligible for edema evaluation. Both groups were paired with age- and sex-matched controls. The median left ventricle LGE was 6.4% (interquartile range 5.0-9.2%) at the acute phase, 4.4% (3.3-7.2%) at follow-up, and 4.3% (3.0-5.3%) in controls, the acute phase being higher than both follow-up and controls (<em>p &lt;</em> 0.001 for both), while follow-up and controls did not differ (<em>p =</em> 0.139). An optimal threshold of 5.0% was obtained for LGE with 87% sensitivity and 48% specificity; the positive likelihood ratio (LR) was 1.67, and the negative LR was 0.27. Edema was 12.8% (9.4-18.1%) at the acute phase, 7.3% (5.5-8.8%) at follow-up, and 6.7% (5.6-8.6%) in controls, the acute phase being higher than both follow-up and controls (both <em>p &lt;</em> 0.001), while follow-up and controls did not differ (<em>p =</em> 0.900). An optimal threshold of 9.5% was obtained for edema with a sensitivity of 76% and a specificity of 88%; the positive LR was 6.33, and the negative LR was 0.27. LGE and edema thresholds are useful in cases of suspected mild myocarditis.
DOI: 10.5281/zenodo.7431535
title: Pre-clinical spheroid models identify BMX as a therapeutic target for metastatic MYCN non-amplified neuroblastoma

description: The development of targeted therapies has provided new hope for an increasing number of cancer patients affected by previously incurable diseases. The clinical success of this approach, however, is limited by numerous challenges, including a better control of cell plasticity, particularly in refractory and metastatic patients. Here we addressed this question in Neuroblastoma (NB), an aggressive pediatric malignancy, which remains a clinical challenge for high-risk patients. NB originates from neural crest-derived progenitors through defective differentiation programs combined with oncogenic activity due to genetic and epigenetic alterations. In order to identify critical genes responsible for tumor aggressiveness we performed combined chromatin and transcriptome analyses on matched primary xenografts, spheroids and differentiated adherent cultures, which we derived from metastatic non-<em>MYCN</em> amplified (nMNA) NB patients. Our approach identified the kinase <em>BMX</em> among the most differentially regulated genes between patient-derived xenografts and spheroids versus adherent models. We further found that <em>BMX</em> expression is associated with high tumor stage and poor patient survival in multiple NB transcriptomic datasets and critical to maintain the self-renewal and tumorigenic potential of NB spheroids. Moreover, we uncovered a positive correlation between <em>BMX </em>expression and the mesenchymal tumor cell phenotype, which was previously associated with increased chemo-resistance. Finally, we show that BMX inhibitors can readily reverse this cellular state, increase the sensitivity of NB spheroids toward standard of care chemotherapy, and reduce tumor growth in preclinical NB models. Altogether, our study identifies BMX as a novel promising therapeutic target for high-risk patients with relapsed or refractory nMNA NB tumors.
DOI: 10.5281/zenodo.7431534
title: Pre-clinical spheroid models identify BMX as a therapeutic target for metastatic MYCN non-amplified neuroblastoma

description: The development of targeted therapies has provided new hope for an increasing number of cancer patients affected by previously incurable diseases. The clinical success of this approach, however, is limited by numerous challenges, including a better control of cell plasticity, particularly in refractory and metastatic patients. Here we addressed this question in Neuroblastoma (NB), an aggressive pediatric malignancy, which remains a clinical challenge for high-risk patients. NB originates from neural crest-derived progenitors through defective differentiation programs combined with oncogenic activity due to genetic and epigenetic alterations. In order to identify critical genes responsible for tumor aggressiveness we performed combined chromatin and transcriptome analyses on matched primary xenografts, spheroids and differentiated adherent cultures, which we derived from metastatic non-<em>MYCN</em> amplified (nMNA) NB patients. Our approach identified the kinase <em>BMX</em> among the most differentially regulated genes between patient-derived xenografts and spheroids versus adherent models. We further found that <em>BMX</em> expression is associated with high tumor stage and poor patient survival in multiple NB transcriptomic datasets and critical to maintain the self-renewal and tumorigenic potential of NB spheroids. Moreover, we uncovered a positive correlation between <em>BMX </em>expression and the mesenchymal tumor cell phenotype, which was previously associated with increased chemo-resistance. Finally, we show that BMX inhibitors can readily reverse this cellular state, increase the sensitivity of NB spheroids toward standard of care chemotherapy, and reduce tumor growth in preclinical NB models. Altogether, our study identifies BMX as a novel promising therapeutic target for high-risk patients with relapsed or refractory nMNA NB tumors.
DOI: 10.21227/30jf-h712
title: TE benchmark

description: The liquid product H in stream 9 is considered as quality variable while 22 process variables XMEAS (1) – XMEAS (22) are selected as process variables. 960 samples are collected as training samples, and another 960 samples are collected as the test dataset in the same working condition.
DOI: 10.3886/icpsr38126.v1
title: Connecticut's Jobs First Program Analysis Data, 1996-2001
title: Version 1

description: This study focused on two of Connecticut's welfare offices, Manchester and New Haven, and used an unusually rigorous research design to provide reliable evidence about Jobs First's impacts -- that is, the difference that Jobs First has made relative to the outcomes generated by the welfare system that preceded it. To facilitate this assessment, between January 1996 and February 1997, several thousand welfare applicants and recipients were assigned, at random, to one of two groups: the Jobs First group, whose members were subject to the welfare reform policies, and the Aid to Families with Dependent Children (AFDC) group, whose members remained subject to the prior welfare rules. People were assigned to the groups through a random process, there were no systematic differences between the groups' members when people entered the study. The two groups experienced the same general economic and social conditions during the study period. Thus, any differences that emerged between the two groups over time -- for example, in employment rates or family income -- can reliably be attributed to Jobs First. The evaluation followed the two groups for four years. The study also collected detailed information about Jobs First's impacts on participants' children, and it includes an analysis comparing the financial benefits and costs of Jobs First for participants and for the government budget.
description: Detailed information on survey weights can be found in the file documentation.
description: Response Rates: The overall response rate was 80 percent.
description: Welfare recipients who applied for benefits between January 1996 and February 1997 were randomly assigned to one of two groups in Manchester and New Haven, Connecticut. The sample size is 4,803.
description: Datasets: DS0: Study-Level Files DS1: CTSURVEY data DS2: CTCHSVY data DS3: CTADMREC data
description: Welfare recipients and their focal children in Connecticut.
description: face-to-face interview; telephone interviewAdditional restricted-access data related to this study is available at the project page on researchdata.gov. Please note that there is a separate application process to access these data.
DOI: 10.3886/icpsr38126
title: Connecticut's Jobs First Program Analysis Data, 1996-2001
title: Archival Version

description: This study focused on two of Connecticut's welfare offices, Manchester and New Haven, and used an unusually rigorous research design to provide reliable evidence about Jobs First's impacts -- that is, the difference that Jobs First has made relative to the outcomes generated by the welfare system that preceded it. To facilitate this assessment, between January 1996 and February 1997, several thousand welfare applicants and recipients were assigned, at random, to one of two groups: the Jobs First group, whose members were subject to the welfare reform policies, and the Aid to Families with Dependent Children (AFDC) group, whose members remained subject to the prior welfare rules. People were assigned to the groups through a random process, there were no systematic differences between the groups' members when people entered the study. The two groups experienced the same general economic and social conditions during the study period. Thus, any differences that emerged between the two groups over time -- for example, in employment rates or family income -- can reliably be attributed to Jobs First. The evaluation followed the two groups for four years. The study also collected detailed information about Jobs First's impacts on participants' children, and it includes an analysis comparing the financial benefits and costs of Jobs First for participants and for the government budget.
description: Detailed information on survey weights can be found in the file documentation.
description: Response Rates: The overall response rate was 80 percent.
description: Welfare recipients who applied for benefits between January 1996 and February 1997 were randomly assigned to one of two groups in Manchester and New Haven, Connecticut. The sample size is 4,803.
description: Datasets: DS0: Study-Level Files DS1: CTSURVEY data DS2: CTCHSVY data DS3: CTADMREC data
description: Welfare recipients and their focal children in Connecticut.
description: face-to-face interview; telephone interviewAdditional restricted-access data related to this study is available at the project page on researchdata.gov. Please note that there is a separate application process to access these data.
DOI: 10.25422/azu.data.21948254
title: Data for "Spatial Scale of Non-Target Effects of Cotton Insecticides"

description: These data were used in the analyses and charts of the peer-reviewed research article "Spatial Scale of Non-Target Effects of Cotton Insecticides". The data files have the counts for <em>Bemisia argentifolii</em>, <em>Lygus hesperus</em>, key whitefly predators, and several other arthropods collected over time in cotton experiments from 2017 and 2018. There is also a file with records on the sources of mortality of sentinel prey cohorts. <i>For inquiries regarding the contents of this dataset, please contact the Corresponding Author listed in the README.txt file. Administrative inquiries (e.g., removal requests, trouble downloading, etc.) can be directed to data-management@arizona.edu</i>
DOI: 10.25422/azu.data.21948254.v1
title: Data for "Spatial Scale of Non-Target Effects of Cotton Insecticides"

description: These data were used in the analyses and charts of the peer-reviewed research article "Spatial Scale of Non-Target Effects of Cotton Insecticides". The data files have the counts for <em>Bemisia argentifolii</em>, <em>Lygus hesperus</em>, key whitefly predators, and several other arthropods collected over time in cotton experiments from 2017 and 2018. There is also a file with records on the sources of mortality of sentinel prey cohorts. <i>For inquiries regarding the contents of this dataset, please contact the Corresponding Author listed in the README.txt file. Administrative inquiries (e.g., removal requests, trouble downloading, etc.) can be directed to data-management@arizona.edu</i>
DOI: 10.18112/openneuro.ds004346.v1.0.4
title: FLUX: A pipeline for MEG analysis
DOI: 10.5281/zenodo.7576260
title: Simulation Results for "Characteristics of Electron Precipitation Directly Driven by Poloidal ULF waves"

description: This dataset contains the simulation results and the corresponding code to produce the figures in the manuscript "Characteristics of Electron Precipitation Directly Driven by Poloidal ULF waves". The name of each data file indicates its corresponding figure, and the Matlab code could be used to produce the figures in the manuscript.
DOI: 10.5281/zenodo.7576259
title: Simulation Results for "Characteristics of Electron Precipitation Directly Driven by Poloidal ULF waves"

description: This dataset contains the simulation results and the corresponding code to produce the figures in the manuscript "Characteristics of Electron Precipitation Directly Driven by Poloidal ULF waves". The name of each data file indicates its corresponding figure, and the Matlab code could be used to produce the figures in the manuscript.
DOI: 10.6084/m9.figshare.17197847.v1
title: “Heat waves” experienced during larval life have species-specific consequences on life-history traits and sexual development in anuran amphibians

description: Extreme temperatures during heat waves can induce mass-mortality events, but can also exert sublethal negative effects by compromising life-history traits and derailing sexual development. Ectothermic animals may, however, also benefit from increased temperatures via enhanced physiological performance and the suppression of cold-adapted pathogens. Therefore, it is crucial to address how the intensity and timing of naturally occurring or human-induced heat waves affect life-history traits and sexual development in amphibians, to predict future effects of climate change and to minimise risks arising from the application of elevated temperature in disease mitigation. We raised agile frog (<i>Rana dalmatina</i>; Bonaparte, 1840) and common toad (<i>Bufo bufo</i>; Linnaeus, 1758) tadpoles at 19 °C and exposed them to a simulated heat wave of 28 or 30 °C for six days during one of three ontogenetic periods (early, mid or late larval development). In agile frogs, exposure to 30 °C during early larval development increased mortality. Regardless of timing, all heat-treatments delayed metamorphosis, and exposure to 30 °C decreased body mass at metamorphosis. Furthermore, exposure to 30 °C during any period and to 28 °C late in development caused female-to-male sex reversal, skewing sex ratios strongly towards males. In common toads, high temperature only slightly decreased survival and did not influence phenotypic sex ratio, while it reduced metamorph mass and length of larval development. Juvenile body mass measured two months after metamorphosis was not altered by temperature treatments in either species. Our results indicate that heat waves may have devastating effects on amphibian populations, and the severity of these negative consequences, and sensitivity can vary greatly between species and with the timing and intensity of heat. Finally, thermal treatments against cold-adapted pathogens have to be executed with caution, taking into account the thermo-sensitivity of the species and the life stage of animals to be treated.
DOI: 10.6084/m9.figshare.21506976.v1
title: Data File 1

description: Time-averaged intensity spectra for dry-O2 fits (1270 nm) in Fig. 7, and CSV file of time-stamped fit parameters for each spectrum with associated meteorology and instrument conditions. Tabulated absorption feature residuals in Fig. 5. Finally, x-y data accompanying each figure.
DOI: 10.6084/m9.figshare.17197847
title: “Heat waves” experienced during larval life have species-specific consequences on life-history traits and sexual development in anuran amphibians

description: Extreme temperatures during heat waves can induce mass-mortality events, but can also exert sublethal negative effects by compromising life-history traits and derailing sexual development. Ectothermic animals may, however, also benefit from increased temperatures via enhanced physiological performance and the suppression of cold-adapted pathogens. Therefore, it is crucial to address how the intensity and timing of naturally occurring or human-induced heat waves affect life-history traits and sexual development in amphibians, to predict future effects of climate change and to minimise risks arising from the application of elevated temperature in disease mitigation. We raised agile frog (<i>Rana dalmatina</i>; Bonaparte, 1840) and common toad (<i>Bufo bufo</i>; Linnaeus, 1758) tadpoles at 19 °C and exposed them to a simulated heat wave of 28 or 30 °C for six days during one of three ontogenetic periods (early, mid or late larval development). In agile frogs, exposure to 30 °C during early larval development increased mortality. Regardless of timing, all heat-treatments delayed metamorphosis, and exposure to 30 °C decreased body mass at metamorphosis. Furthermore, exposure to 30 °C during any period and to 28 °C late in development caused female-to-male sex reversal, skewing sex ratios strongly towards males. In common toads, high temperature only slightly decreased survival and did not influence phenotypic sex ratio, while it reduced metamorph mass and length of larval development. Juvenile body mass measured two months after metamorphosis was not altered by temperature treatments in either species. Our results indicate that heat waves may have devastating effects on amphibian populations, and the severity of these negative consequences, and sensitivity can vary greatly between species and with the timing and intensity of heat. Finally, thermal treatments against cold-adapted pathogens have to be executed with caution, taking into account the thermo-sensitivity of the species and the life stage of animals to be treated.
DOI: 10.5281/zenodo.7576393
title: Quantitative Assessment of Late Gadolinium Enhancement and Edema at Cardiac Magnetic Resonance in Low-Risk Myocarditis Patients

description: Monti CB, Secchi F, Alì M, Carbone FS, Bonomo L, Capra D, Mobini N, Di Leo G, Sardanelli F. Quantitative Assessment of Late Gadolinium Enhancement and Edema at Cardiac Magnetic Resonance in Low-Risk Myocarditis Patients. Tomography. 2022 Apr 1;8(2):974-984. doi: 10.3390/tomography8020078. PMID: 35448712; PMCID: PMC9028348. Abstract In this study, we aimed to quantify LGE and edema at short-tau inversion recovery sequences on cardiac magnetic resonance (CMR) in patients with myocarditis. We retrospectively evaluated CMR examinations performed during the acute phase and at follow-up. Forty-seven patients were eligible for retrospective LGE assessment, and, among them, twenty-five patients were eligible for edema evaluation. Both groups were paired with age- and sex-matched controls. The median left ventricle LGE was 6.4% (interquartile range 5.0-9.2%) at the acute phase, 4.4% (3.3-7.2%) at follow-up, and 4.3% (3.0-5.3%) in controls, the acute phase being higher than both follow-up and controls (<em>p &lt;</em> 0.001 for both), while follow-up and controls did not differ (<em>p =</em> 0.139). An optimal threshold of 5.0% was obtained for LGE with 87% sensitivity and 48% specificity; the positive likelihood ratio (LR) was 1.67, and the negative LR was 0.27. Edema was 12.8% (9.4-18.1%) at the acute phase, 7.3% (5.5-8.8%) at follow-up, and 6.7% (5.6-8.6%) in controls, the acute phase being higher than both follow-up and controls (both <em>p &lt;</em> 0.001), while follow-up and controls did not differ (<em>p =</em> 0.900). An optimal threshold of 9.5% was obtained for edema with a sensitivity of 76% and a specificity of 88%; the positive LR was 6.33, and the negative LR was 0.27. LGE and edema thresholds are useful in cases of suspected mild myocarditis.
DOI: 10.5281/zenodo.7576392
title: Quantitative Assessment of Late Gadolinium Enhancement and Edema at Cardiac Magnetic Resonance in Low-Risk Myocarditis Patients

description: Monti CB, Secchi F, Alì M, Carbone FS, Bonomo L, Capra D, Mobini N, Di Leo G, Sardanelli F. Quantitative Assessment of Late Gadolinium Enhancement and Edema at Cardiac Magnetic Resonance in Low-Risk Myocarditis Patients. Tomography. 2022 Apr 1;8(2):974-984. doi: 10.3390/tomography8020078. PMID: 35448712; PMCID: PMC9028348. Abstract In this study, we aimed to quantify LGE and edema at short-tau inversion recovery sequences on cardiac magnetic resonance (CMR) in patients with myocarditis. We retrospectively evaluated CMR examinations performed during the acute phase and at follow-up. Forty-seven patients were eligible for retrospective LGE assessment, and, among them, twenty-five patients were eligible for edema evaluation. Both groups were paired with age- and sex-matched controls. The median left ventricle LGE was 6.4% (interquartile range 5.0-9.2%) at the acute phase, 4.4% (3.3-7.2%) at follow-up, and 4.3% (3.0-5.3%) in controls, the acute phase being higher than both follow-up and controls (<em>p &lt;</em> 0.001 for both), while follow-up and controls did not differ (<em>p =</em> 0.139). An optimal threshold of 5.0% was obtained for LGE with 87% sensitivity and 48% specificity; the positive likelihood ratio (LR) was 1.67, and the negative LR was 0.27. Edema was 12.8% (9.4-18.1%) at the acute phase, 7.3% (5.5-8.8%) at follow-up, and 6.7% (5.6-8.6%) in controls, the acute phase being higher than both follow-up and controls (both <em>p &lt;</em> 0.001), while follow-up and controls did not differ (<em>p =</em> 0.900). An optimal threshold of 9.5% was obtained for edema with a sensitivity of 76% and a specificity of 88%; the positive LR was 6.33, and the negative LR was 0.27. LGE and edema thresholds are useful in cases of suspected mild myocarditis.