cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.22005080
title: Supplementary Material for: Regional Variation of Erythropoiesis-Stimulating Agent Hyporesponsiveness in the Global Daprodustat Dialysis Study (ASCEND-D)

description: Introduction: Hyporesponsiveness to erythropoiesis-stimulating agents (ESAs) affects 10–15% of the chronic dialysis population. We explored baseline characteristics and predictors of ESA hyporesponsiveness in a global randomized cardiovascular outcomes study comparing an investigational hypoxia-inducible factor prolyl hydroxylase inhibitor (HIF-PHI), daprodustat, with conventional ESA treatment. Methods: ASCEND-D (NCT02879305) recruited 2964 chronic dialysis patients receiving ESA treatment (standardized to weekly intravenous [IV] epoetin) who were iron replete at baseline. The primary ESA hyporesponsiveness definition was an ESA Resistance Index (ERI, ESA Units/kg/week/hemoglobin g/l) ≥2 or IV standardized ESA dose ≥450 Units/kg/week. Predictors of ESA hyporesponsiveness were determined using a multivariable regression model. Alternative hyporesponder definitions were explored. Results: Using the primary definition, 354 (12%) patients were ESA hyporesponsive. Geographic region, notably Latin America, lower baseline body mass index and transferrin saturation, younger age, lower albumin concentration, and a higher baseline IV iron dose were identified as strongly associated (P &lt; 0.001) with ESA hyporesponsiveness. Additional predictors of ESA hyporesponsiveness included female sex (P = 0.010), history of heart failure (P = 0.035), longer dialysis vintage (P = 0.077), smoking status (P = 0.247), aspirin use (P = 0.121), and angiotensin-converting enzyme inhibitor/ angiotensin receptor blocker use (P = 0.214). Conclusion: This is the first global HIF-PHI study to report pre-specified definitions and predictors of ESA hyporesponsiveness. While most of the predictors identified in our study have been previously reported, geographic region stands out as an unexpected finding, meriting further investigation.
DOI: 10.6084/m9.figshare.22005080.v1
title: Supplementary Material for: Regional Variation of Erythropoiesis-Stimulating Agent Hyporesponsiveness in the Global Daprodustat Dialysis Study (ASCEND-D)

description: Introduction: Hyporesponsiveness to erythropoiesis-stimulating agents (ESAs) affects 10–15% of the chronic dialysis population. We explored baseline characteristics and predictors of ESA hyporesponsiveness in a global randomized cardiovascular outcomes study comparing an investigational hypoxia-inducible factor prolyl hydroxylase inhibitor (HIF-PHI), daprodustat, with conventional ESA treatment. Methods: ASCEND-D (NCT02879305) recruited 2964 chronic dialysis patients receiving ESA treatment (standardized to weekly intravenous [IV] epoetin) who were iron replete at baseline. The primary ESA hyporesponsiveness definition was an ESA Resistance Index (ERI, ESA Units/kg/week/hemoglobin g/l) ≥2 or IV standardized ESA dose ≥450 Units/kg/week. Predictors of ESA hyporesponsiveness were determined using a multivariable regression model. Alternative hyporesponder definitions were explored. Results: Using the primary definition, 354 (12%) patients were ESA hyporesponsive. Geographic region, notably Latin America, lower baseline body mass index and transferrin saturation, younger age, lower albumin concentration, and a higher baseline IV iron dose were identified as strongly associated (P &lt; 0.001) with ESA hyporesponsiveness. Additional predictors of ESA hyporesponsiveness included female sex (P = 0.010), history of heart failure (P = 0.035), longer dialysis vintage (P = 0.077), smoking status (P = 0.247), aspirin use (P = 0.121), and angiotensin-converting enzyme inhibitor/ angiotensin receptor blocker use (P = 0.214). Conclusion: This is the first global HIF-PHI study to report pre-specified definitions and predictors of ESA hyporesponsiveness. While most of the predictors identified in our study have been previously reported, geographic region stands out as an unexpected finding, meriting further investigation.
DOI: 10.25550/2m-04a8
title: Factors contributing to oral health disparities in Appalachia

description: Oral disease, in particular childhood caries, remains a major health burden which affects some communities disproportionally, including regions of Appalachia. Both increased sugar intake and frequency of exposure alter the oral microbial community, triggering a disease process that leads to caries. Additional factors associated with caries in children include genetic risk, household SES, maternal caregiving behavior and stress, access to care. Progress has been made in understanding many of these factors. However, much remains to be done in order to further characterize individual risk factors, but just as importantly, to determine how interactions between them lead to oral health disparities. The current proposal is a renewal of our ongoing project (R01-DE-014899) to identify factors contributing to the oral health disparity seen in northern Appalachia. The guiding philosophy of our project (the Center for Oral Health Research in Appalachia; COHRA) has been and continues to be that developing strategies to address this disparity requires simultaneous study of multiple risk components (ideally within families) to determine their roles, interactions among them, and their transmissibility patterns. COHRA’s long-term goal remains to determine the sources of oral health disparity in a high risk, Northern Appalachian population so that effective preventive interventions can be designed and targeted. During the previous project period that began Sept 1, 2009, we recruited a cohort of approximately 1000 northern Appalachian women during pregnancy (COHRA2), following them and their children through their children’s second birthday. This prospective study of mother-child pairs complements the original cohort of approximately 840 northern Appalachian families (COHRA1) by gathering multifaceted, longitudinal data on the earliest antecedents of caries formation. As detailed in the progress report, the specific aims of the previous project period (using both COHRA1 and COHRA2 cohorts) were all accomplished (recruitment targets, genetic analyses of the COHRA1 cohort, psychosocial investigations, microbial assessments). We propose to follow the current COHRA2 cohort as it grows from ages 2 to 6, and to use the resulting longitudinal demographic, medical, diet, and psychosocial data to test hypotheses about the causal relationships between risk factors contributing to the unusually high rates of caries formation in this population. We will integrate the additional data to be collected with existing and new genetic and microbial data to identify “cariogenic profiles,” in which the interactions between mother and child genetics, oral ecology, diet, and other environmental/psychosocial behaviors in infancy and early childhood are combined to predict unusually high risks for onset of caries before age 6.
DOI: 10.5281/zenodo.7602563
title: Data for "Including ash in UKESM1 model simulations of the Raikoke volcanic eruption reveal improved agreement with observations" by Wells et al., 2023

description: Data used for figures in "Including ash in UKESM1 model simulations of the Raikoke volcanic eruption reveal improved agreement with observations" by Wells et al., 2023 See https://github.com/awells96/Raikoke for code to reproduce the figures.
DOI: 10.5281/zenodo.7602562
title: Data for "Including ash in UKESM1 model simulations of the Raikoke volcanic eruption reveal improved agreement with observations" by Wells et al., 2023

description: Data used for figures in "Including ash in UKESM1 model simulations of the Raikoke volcanic eruption reveal improved agreement with observations" by Wells et al., 2023 See https://github.com/awells96/Raikoke for code to reproduce the figures.
DOI: 10.25934/pr00002037.0
title: Available datapackage for study 'An Open-Label, Uncontrolled, Long-Term Study to Assess the Safety of LAMICTAL in Pediatric Subjects Previously Enrolled in Protocol LAM20006 and In LAMICTAL-naive Subjects (1-24 Months of Age)'

description: This study will evaluate the long-term safety of LAMICTAL(lamotrigine)in subjects with partial seizures previously enrolled in protocol LAM20006 and in subjects 1-24 months of age who have never received LAMICTAL(LAMICTAL-naive). For LAMICTAL-naive subjects, LAMICTAL will be added to the subject's current epilepsy medications.
DOI: 10.15129/67521ce7-3184-47bf-8d63-4764ae5d1951
title: A 2018 UK SAM for CCS deployment with and without shipping

description: This is a 2018 Social Accounting Matrix (SAM) of the UK for use in projects aiming to explore the introduction of a Carbon Capture and Storage (CCS), transport and storage specifically, sector in the UK economy. We include two variations: one where the transportation is done exclusively over pipelines and another where a mix of pipelines and shipping is used. In the version where only pipelines are used, the CCS sector is assumed to be identical, in terms of its supply chain and production technology, to the existing UK Oil and Gas sector. In fact, it has been created by disaggregating the Oil and Gas sector. Where a mix of pipelines and shipping is used, the inputs of the CCS sector are adjusted appropriately to reflect the fact that less capital is necessary to be owned and operated by the sector and at the same time more imports of shipping services are necessary. This SAM incorporates the latest input-output tables published by the Office for National Statistics.
DOI: 10.5281/zenodo.7602535
title: Datasets for "Targeted insertion and reporter transgene activity at a gene safe harbor of the human blood fluke, Schistosoma mansoni"

description: To identify sites that could serve as potential genomic safe harbours (GSHs) for transgene integration, we conducted a genome-wide bioinformatic search based on established, widely accepted criteria, along with newly introduced criteria (below), that would satisfy benign and stable gene expression. At the outset, we identified <strong>euchromatic</strong> regions in all developmental stages of <em>S. mansoni </em>to avoid silencing genes to be integrated upon CRISPR/Cas manipulation. With these criteria, we enriched for regions that were, (i) close to peaks of H3K4me3, a histone modification that is associated with euchromatin and transcription start sites, (ii) regions that did not include H3K27me3, a histone modification that is associated with heterochromatin, (iii) regions of open euchromatin accessible to Tn5 integration, in an Assay of Transposase Accessible Chromatin sequencing (ATAC-seq) providing a positive display of integration events, and (iv) given that HIV-1 integrates preferentially into euchromatin in human cell lines, we used sites of HIV proviral integration known from <em>S. mansoni</em> to likewise support predictions of euchromatic regions. Examination of the draft genome of <em>S. mansoni</em> in Worm Base Parasite, version 7 (WormBase Parasite) identified 6,884 regions with enrichment of H3K4me3 in the absence of H3K27me3 in available developmental stages (H3K4me3 not K3K27me3). In mature, adult schistosomes, we found consistently 10,533 ATAC positive regions. There were 4,027 ATAC regions that overlapped with H3K4me3 but not K3K27me3, and 2,915 genes overlapped with (ATAC and H3K4me3 not H3K27me3). Forty-two unambiguous HIV integration sites were identified, and eight genes were ≤ 11 kb upstream or downstream from these integration sites. Repeats were masked with RepeatMasker V4.1.0 using a specific repeat library produced with RepeatModeler2 V2.0.1 and stored as a GFF file. To identify intergenic GSH, we located 10,149 intergenic regions. There were 9,985 regions beyond 2 kb upstream and 8,837 regions outside long non-coding-RNA (lncRNA), which were intersected to 95,587 unique intergenic regions outside 2 kb and lncRNA of ≥100 bp. Two hundred regions were identified intersecting with merged ATAC H3K4me3 signal. Four of these were situated ≤ 11 kb distance from HIV integration sites. Made at George Washington University, Justus Liebig University Giessen, Khon Kaen University, Naresuan University, Aberystwyth University, Schistosomiasis Resource Center, IHPE.
DOI: 10.5281/zenodo.7602534
title: Datasets for "Targeted insertion and reporter transgene activity at a gene safe harbor of the human blood fluke, Schistosoma mansoni"

description: To identify sites that could serve as potential genomic safe harbours (GSHs) for transgene integration, we conducted a genome-wide bioinformatic search based on established, widely accepted criteria, along with newly introduced criteria (below), that would satisfy benign and stable gene expression. At the outset, we identified <strong>euchromatic</strong> regions in all developmental stages of <em>S. mansoni </em>to avoid silencing genes to be integrated upon CRISPR/Cas manipulation. With these criteria, we enriched for regions that were, (i) close to peaks of H3K4me3, a histone modification that is associated with euchromatin and transcription start sites, (ii) regions that did not include H3K27me3, a histone modification that is associated with heterochromatin, (iii) regions of open euchromatin accessible to Tn5 integration, in an Assay of Transposase Accessible Chromatin sequencing (ATAC-seq) providing a positive display of integration events, and (iv) given that HIV-1 integrates preferentially into euchromatin in human cell lines, we used sites of HIV proviral integration known from <em>S. mansoni</em> to likewise support predictions of euchromatic regions. Examination of the draft genome of <em>S. mansoni</em> in Worm Base Parasite, version 7 (WormBase Parasite) identified 6,884 regions with enrichment of H3K4me3 in the absence of H3K27me3 in available developmental stages (H3K4me3 not K3K27me3). In mature, adult schistosomes, we found consistently 10,533 ATAC positive regions. There were 4,027 ATAC regions that overlapped with H3K4me3 but not K3K27me3, and 2,915 genes overlapped with (ATAC and H3K4me3 not H3K27me3). Forty-two unambiguous HIV integration sites were identified, and eight genes were ≤ 11 kb upstream or downstream from these integration sites. Repeats were masked with RepeatMasker V4.1.0 using a specific repeat library produced with RepeatModeler2 V2.0.1 and stored as a GFF file. To identify intergenic GSH, we located 10,149 intergenic regions. There were 9,985 regions beyond 2 kb upstream and 8,837 regions outside long non-coding-RNA (lncRNA), which were intersected to 95,587 unique intergenic regions outside 2 kb and lncRNA of ≥100 bp. Two hundred regions were identified intersecting with merged ATAC H3K4me3 signal. Four of these were situated ≤ 11 kb distance from HIV integration sites. Made at George Washington University, Justus Liebig University Giessen, Khon Kaen University, Naresuan University, Aberystwyth University, Schistosomiasis Resource Center, IHPE.
DOI: 10.5281/zenodo.7602625
title: Anonymous

description: Supplementary data and scripts intended for submission review only.
DOI: 10.5281/zenodo.7602624
title: Anonymous

description: Supplementary data and scripts intended for submission review only.
DOI: 10.5281/zenodo.7602668
title: Infection safe workplace IoT sensor measurements

description: This dataset has been collected and created by "Datu Tehnoloģiju Grupa" and Riga Technical University. This dataset contains data collected from IoT devices scattered in the office workplace. The measurements have been collected in a .csv file, with 150000 records. Project “Platform for the Covid-19 safe work environment” (ID. 1.1.1.1/21/A/011) is founded by European Regional Development Fund specific objective 1.1.1 «Improve research and innovation capacity and the ability of Latvian research institutions to attract external funding, by investing in human capital and infra-structure». The project is co-financed by REACT-EU funding for mitigating the consequences of the pan-demic crisis.
DOI: 10.34740/kaggle/dsv/4941451
title: Global Genomic Neurofibromatosis Neoplasia
DOI: 10.34740/kaggle/dsv/4941463
title: UNET Lung Segmentation Weights for Chest X Rays
DOI: 10.5281/zenodo.7602603
title: Infection safe workplace IoT sensor measurements

description: This dataset has been collected and created by "Datu Tehnoloģiju Grupa" and Riga Technical University. This dataset contains data collected from IoT devices scattered in the office workplace. The measurements have been collected in a .csv file, with 150000 records. This is part of a project called “Platform for the Covid-19-safe work environment”, ID. 1.1.1.1/21/A/011"
DOI: 10.5281/zenodo.7602590
title: Prognostic value of left atrial strain quantification from 2D ultrasound imaging in post-ischemic heart failure patients: evidence from the REMODEL-HF study.

description: Frigelli M, Sturla F, Milani V, Ramputi L, Citarella M, Menicanti L, Votta E, Castelvecchio S. Prognostic value of left atrial strain quantification from 2D ultrasound imaging in post-ischemic heart failure patients: evidence from the REMODEL-HF study. Int J Cardiol. 2022 Sep 1;362:183-189. doi: 10.1016/j.ijcard.2022.04.071. Epub 2022 Apr 30. PMID: 35504452. Abstract <strong>Background: </strong>Left atrial (LA) function can be effectively assessed by measuring longitudinal LA strain (LAS) via two-dimensional speckle tracking echocardiography (2DSTE). Here, we test 2DSTE-based LAS as marker of different left ventricle (LV) remodeling patterns and as prognostic index in ischemic heart failure (HF) candidates to surgical ventricular reconstruction. <strong>Methods: </strong>We retrospectively considered ischemic HF patients with anterior (group A, n=130) or posterior (group P, n=48) LV remodeling. Based on 2D ultrasound, LV and LA morpho-functional parameters were quantified including reservoir (LAS<sub>Res</sub>), conduit (LAS<sub>Cond</sub>) and booster (LAS<sub>Boost</sub>) LAS. We tested their capability to discriminate between groups A and P, and their group-specific prognostic significance for the composite end-point of death or HF re-hospitalization at follow-up (mean follow-up time=40 months, range 3-101 months). <strong>Results: </strong>Group A and group P displayed similar end-diastolic (p=0.89) and end-systolic (p=0.33) LV volume index, and LA volume index LAVi (p=0.44) corrected for the degree of mitral regurgitation. As compared to group P, group A revealed a significant reduction in LAS<sub>Boost</sub> (9.2±0.4% vs. 11.1±0.7%, p=0.04) and a non-significant reduction in LAS<sub>Res</sub> (16.9±0.7% vs. 19.3±1.1%, p=0.06). Kaplan-Meier curves showed that the median LAS<sub>Res</sub> and LAS<sub>Boost</sub> values effectively stratified patients based on their prognosis in the overall study population (Log-rank p=0.002 and Log_rank p&lt;0.0001) and in group A, where the association was stronger for LAS<sub>Boost</sub> (Log-rank p&lt;0.001) than for LAS<sub>Res</sub> (Log-rank p=0.013). <strong>Conclusions: </strong>2DSTE-based LAS assessment is affordable, repeatable and non-invasive, and could add clinically-relevant mechanistic insight and prognostic value in the stratification of ischemic HF patients.
DOI: 10.5281/zenodo.7602589
title: Prognostic value of left atrial strain quantification from 2D ultrasound imaging in post-ischemic heart failure patients: evidence from the REMODEL-HF study.

description: Frigelli M, Sturla F, Milani V, Ramputi L, Citarella M, Menicanti L, Votta E, Castelvecchio S. Prognostic value of left atrial strain quantification from 2D ultrasound imaging in post-ischemic heart failure patients: evidence from the REMODEL-HF study. Int J Cardiol. 2022 Sep 1;362:183-189. doi: 10.1016/j.ijcard.2022.04.071. Epub 2022 Apr 30. PMID: 35504452. Abstract <strong>Background: </strong>Left atrial (LA) function can be effectively assessed by measuring longitudinal LA strain (LAS) via two-dimensional speckle tracking echocardiography (2DSTE). Here, we test 2DSTE-based LAS as marker of different left ventricle (LV) remodeling patterns and as prognostic index in ischemic heart failure (HF) candidates to surgical ventricular reconstruction. <strong>Methods: </strong>We retrospectively considered ischemic HF patients with anterior (group A, n=130) or posterior (group P, n=48) LV remodeling. Based on 2D ultrasound, LV and LA morpho-functional parameters were quantified including reservoir (LAS<sub>Res</sub>), conduit (LAS<sub>Cond</sub>) and booster (LAS<sub>Boost</sub>) LAS. We tested their capability to discriminate between groups A and P, and their group-specific prognostic significance for the composite end-point of death or HF re-hospitalization at follow-up (mean follow-up time=40 months, range 3-101 months). <strong>Results: </strong>Group A and group P displayed similar end-diastolic (p=0.89) and end-systolic (p=0.33) LV volume index, and LA volume index LAVi (p=0.44) corrected for the degree of mitral regurgitation. As compared to group P, group A revealed a significant reduction in LAS<sub>Boost</sub> (9.2±0.4% vs. 11.1±0.7%, p=0.04) and a non-significant reduction in LAS<sub>Res</sub> (16.9±0.7% vs. 19.3±1.1%, p=0.06). Kaplan-Meier curves showed that the median LAS<sub>Res</sub> and LAS<sub>Boost</sub> values effectively stratified patients based on their prognosis in the overall study population (Log-rank p=0.002 and Log_rank p&lt;0.0001) and in group A, where the association was stronger for LAS<sub>Boost</sub> (Log-rank p&lt;0.001) than for LAS<sub>Res</sub> (Log-rank p=0.013). <strong>Conclusions: </strong>2DSTE-based LAS assessment is affordable, repeatable and non-invasive, and could add clinically-relevant mechanistic insight and prognostic value in the stratification of ischemic HF patients.
DOI: 10.57745/dijdq0
title: 00_Présentation_du_jeu_de_données.pdf

description: :unav
DOI: 10.57745/aymowm
title: 04_J4_seance_3.zip

description: :unav
DOI: 10.57745/3n3qyt
title: 06_J7A_regroupement_3.zip

description: :unav
DOI: 10.57745/o4e6tn
title: 05_J6B_regroupement_2.zip

description: :unav
DOI: 10.57745/uohkxf
title: 03_J3_seance_2.zip

description: :unav
DOI: 10.57745/x333pk
title: 02_J0B_seance_1.zip

description: :unav
DOI: 10.57745/uagss9
title: 08_J11_seance 6.zip

description: :unav
DOI: 10.57745/jf8ltn
title: 10_J47_Transcription_AC_simple.zip

description: :unav
DOI: 10.57745/tytq8h
title: 09_J40_Transcription_AC_simple.zip

description: :unav
DOI: 10.57745/gny8nn
title: 01_J0A_regroupement_1.zip

description: :unav
DOI: 10.57745/k4mrju
title: 07_J7B_seance_5.zip

description: :unav
DOI: 10.5281/zenodo.7602508
title: Titanic

description: CSV titanic
DOI: 10.5281/zenodo.7602507
title: Titanic

description: CSV titanic
DOI: 10.6084/m9.figshare.21977324.v1
title: Video information and tracking performances

description: An Excel file including three tables. Table 1: Characteristics of the videos and tracing challenges. Table 2: Parameters used for the tracking with AnimalTA Table 3: Performance of the tracking and comparison with two other programs.
DOI: 10.5281/zenodo.7476147
title: Replication package for: The Lost Capital Asset Pricing Model

description: The package contains the codes and the data analysis files necessary to reproduce the figures and tables in Andrei, Cujean, and Wilson (forthcoming), "The Lost Capital Asset Pricing Model," Review of Economic Studies. Detailed instructions are also given about accessing the raw data.
DOI: 10.5281/zenodo.7348949
title: Replication package for: The Lost Capital Asset Pricing Model

description: The package contains the codes and the data analysis files necessary to reproduce the figures and tables in Andrei, Cujean, and Wilson (forthcoming), "The Lost Capital Asset Pricing Model," Review of Economic Studies. Detailed instructions are also given about accessing the raw data.