cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.1568190.v1
title: A new fossil actinistian from the Early Jurassic of Chile and its bearing on the phylogeny of Actinistia

description: ABSTRACTWe present the description and taxonomic reassignment of a new genus and species, <i>Atacamaia solitaria</i>, gen. et sp. nov., from Lower Jurassic strata of northern Chile, South America. The fish was previously reported as a new genus of Mawsoniidae, based on one unprepared specimen. The fish is characterized by a combination of numerous intriguing characters, such as the presence of a broad parietal bone partially covered laterally by a series of a few large supraorbital bones, a series of sclerotic bones, a lachrymojugal expanded anteriorly and markedly angled, and a metapterygoid with a well-developed ventral process that is ventral to the dorsal margin of the pterygoid plate. Addition of <i>Atacamaia</i> to previously published matrices produces unexpected collapses of certain nodes in the currently accepted phylogenetic hypothesis of Actinistia, creating many polytomies in the consensus tree. Our cladistic analysis suggests that <i>Atacamaia</i>, gen. et sp. nov., <i>Axelia</i>, and <i>Wimania</i> are closely related and together with <i>Piveteauia, Guizhoucoelacanthus</i>, and <i>Whiteia</i> are members of the order Coelacanthiformes. Based on previous analyses and our results, we recognize this grouping as the family Whiteiidae. Members of Whiteiidae are Triassic forms, except <i>Atacamaia solitaria</i>, gen. et sp. nov., from the Early Jurassic. The new fossil actinistian represents the youngest member of the family and the first discovered on the Paleopacific side of Gondwana; all other members are from China, Madagascar, and Spitsbergen. After comparison of previous hypotheses, we review the higher level taxonomy of Actinistia concerning the monophyly of Coelacanthiformes, Latimeroidei, Mawsoniidae, and Latimeriidae and propose a family diagnosis for Whiteiidae.http://zoobank.org/urn:lsid:zoobank.org:pub:1CE8B66D-30D2-44EB-87EF-882628478C3BSUPPLEMENTAL DATA—Supplemental materials are available for this article for free at www.tandfonline.com/UJVP
DOI: 10.6084/m9.figshare.1568189.v1
title: An occurrence of fossil eggs from the Mesozoic of Madagascar and a detailed observation of eggshell microstructure

description: ABSTRACTWhereas fossil turtle eggs have a near global distribution and range from Middle Jurassic to Pleistocene, they are rarely documented from the Mesozoic of Gondwana. Here, we report three fossil turtle eggs from the Upper Cretaceous (Campanian) of the Morondava Basin, Madagascar. The spherical eggs range in size from 33.5 to 35.5 mm and have an average eggshell thickness of 440 µm. They can be confidently identified as rigid-shelled turtle eggs by the presence of tightly packed shell units composed of radiating acicular crystals and a shell unit height to width ratio of 2:1. Lack of associated skeletal remains precludes taxonomic identification of the eggs. Although a large vertebrate fauna has been reported from the Upper Cretaceous of Madagascar, these specimens are the first eggs from the Mesozoic of the island.SUPPLEMENTAL DATA—Supplemental materials are available for this article for free at www.tandfonline.com/UJVP
DOI: 10.6084/m9.figshare.1568190.v3
title: A new fossil actinistian from the Early Jurassic of Chile and its bearing on the phylogeny of Actinistia

description: ABSTRACTWe present the description and taxonomic reassignment of a new genus and species, <i>Atacamaia solitaria</i>, gen. et sp. nov., from Lower Jurassic strata of northern Chile, South America. The fish was previously reported as a new genus of Mawsoniidae, based on one unprepared specimen. The fish is characterized by a combination of numerous intriguing characters, such as the presence of a broad parietal bone partially covered laterally by a series of a few large supraorbital bones, a series of sclerotic bones, a lachrymojugal expanded anteriorly and markedly angled, and a metapterygoid with a well-developed ventral process that is ventral to the dorsal margin of the pterygoid plate. Addition of <i>Atacamaia</i> to previously published matrices produces unexpected collapses of certain nodes in the currently accepted phylogenetic hypothesis of Actinistia, creating many polytomies in the consensus tree. Our cladistic analysis suggests that <i>Atacamaia</i>, gen. et sp. nov., <i>Axelia</i>, and <i>Wimania</i> are closely related and together with <i>Piveteauia, Guizhoucoelacanthus</i>, and <i>Whiteia</i> are members of the order Coelacanthiformes. Based on previous analyses and our results, we recognize this grouping as the family Whiteiidae. Members of Whiteiidae are Triassic forms, except <i>Atacamaia solitaria</i>, gen. et sp. nov., from the Early Jurassic. The new fossil actinistian represents the youngest member of the family and the first discovered on the Paleopacific side of Gondwana; all other members are from China, Madagascar, and Spitsbergen. After comparison of previous hypotheses, we review the higher level taxonomy of Actinistia concerning the monophyly of Coelacanthiformes, Latimeroidei, Mawsoniidae, and Latimeriidae and propose a family diagnosis for Whiteiidae.http://zoobank.org/urn:lsid:zoobank.org:pub:1CE8B66D-30D2-44EB-87EF-882628478C3BSUPPLEMENTAL DATA—Supplemental materials are available for this article for free at www.tandfonline.com/UJVP
DOI: 10.6084/m9.figshare.1568193.v2
title: A new Early Cretaceous brachiosaurid (Dinosauria, Neosauropoda) from northwestern Gondwana (Villa de Leiva, Colombia)

description: ABSTRACTBrachiosaurid sauropods achieved a broad distribution during the Late Jurassic, which has been considered to provide evidence of their origins during the Middle Jurassic, prior to the breakup of Pangea. In contrast to their broad geographic distribution during the Late Jurassic, formally named brachiosaurid species from the Cretaceous have so far been restricted to the Aptian–Albian of North America, which has been interpreted as a signal of differential extinction and/or a bias in the Early Cretaceous fossil record. Here we describe a new brachiosaurid titanosauriform taxon from the Early Cretaceous of Colombia, which is represented by axial elements. The material was recovered from marine sediments of the Paja Formation (Barremian), close to the locality of Villa de Leiva. The weakly laterally expanded and divided transverse processes of the anterior-most caudal vertebrae allows the recognition of a new sauropod taxon, <i>Padillasaurus leivaensis</i>, gen. et sp. nov. In order to test the phylogenetic relationships of the new taxon, we performed a cladistic analysis that recovered <i>Padillasaurus</i> as a brachiosaurid titanosauriform. This position is supported by a combination of characters, including the presence of blind fossae in anterior caudal vertebrae. Among titanosauriforms, the presence of blind fossae in anterior caudal vertebrae is an apomorphic character that is exclusive to <i>Giraffatitan, Venenosaurus, Cedarosaurus</i>, and <i>Abydosaurus</i>. Although more complete remains are needed to test more thoroughly the affinities of the new taxon, the available evidence indicates that brachiosaurids survived at lower latitudes in Gondwana until at least the Early Cretaceous.http://zoobank.org/urn:lsid:zoobank.org:pub:652D6B2A-7A8A-4311-8725-279BF2C9E0E3SUPPLEMENTAL DATA—Supplemental materials are available for this article for free at www.tandfonline.com/UJVP
DOI: 10.6084/m9.figshare.1568189.v3
title: An occurrence of fossil eggs from the Mesozoic of Madagascar and a detailed observation of eggshell microstructure

description: ABSTRACTWhereas fossil turtle eggs have a near global distribution and range from Middle Jurassic to Pleistocene, they are rarely documented from the Mesozoic of Gondwana. Here, we report three fossil turtle eggs from the Upper Cretaceous (Campanian) of the Morondava Basin, Madagascar. The spherical eggs range in size from 33.5 to 35.5 mm and have an average eggshell thickness of 440 µm. They can be confidently identified as rigid-shelled turtle eggs by the presence of tightly packed shell units composed of radiating acicular crystals and a shell unit height to width ratio of 2:1. Lack of associated skeletal remains precludes taxonomic identification of the eggs. Although a large vertebrate fauna has been reported from the Upper Cretaceous of Madagascar, these specimens are the first eggs from the Mesozoic of the island.SUPPLEMENTAL DATA—Supplemental materials are available for this article for free at www.tandfonline.com/UJVP
DOI: 10.6084/m9.figshare.1568190.v2
title: A new fossil actinistian from the Early Jurassic of Chile and its bearing on the phylogeny of Actinistia

description: ABSTRACTWe present the description and taxonomic reassignment of a new genus and species, <i>Atacamaia solitaria</i>, gen. et sp. nov., from Lower Jurassic strata of northern Chile, South America. The fish was previously reported as a new genus of Mawsoniidae, based on one unprepared specimen. The fish is characterized by a combination of numerous intriguing characters, such as the presence of a broad parietal bone partially covered laterally by a series of a few large supraorbital bones, a series of sclerotic bones, a lachrymojugal expanded anteriorly and markedly angled, and a metapterygoid with a well-developed ventral process that is ventral to the dorsal margin of the pterygoid plate. Addition of <i>Atacamaia</i> to previously published matrices produces unexpected collapses of certain nodes in the currently accepted phylogenetic hypothesis of Actinistia, creating many polytomies in the consensus tree. Our cladistic analysis suggests that <i>Atacamaia</i>, gen. et sp. nov., <i>Axelia</i>, and <i>Wimania</i> are closely related and together with <i>Piveteauia, Guizhoucoelacanthus</i>, and <i>Whiteia</i> are members of the order Coelacanthiformes. Based on previous analyses and our results, we recognize this grouping as the family Whiteiidae. Members of Whiteiidae are Triassic forms, except <i>Atacamaia solitaria</i>, gen. et sp. nov., from the Early Jurassic. The new fossil actinistian represents the youngest member of the family and the first discovered on the Paleopacific side of Gondwana; all other members are from China, Madagascar, and Spitsbergen. After comparison of previous hypotheses, we review the higher level taxonomy of Actinistia concerning the monophyly of Coelacanthiformes, Latimeroidei, Mawsoniidae, and Latimeriidae and propose a family diagnosis for Whiteiidae.http://zoobank.org/urn:lsid:zoobank.org:pub:1CE8B66D-30D2-44EB-87EF-882628478C3BSUPPLEMENTAL DATA—Supplemental materials are available for this article for free at www.tandfonline.com/UJVP
DOI: 10.6084/m9.figshare.1568189.v2
title: An occurrence of fossil eggs from the Mesozoic of Madagascar and a detailed observation of eggshell microstructure

description: ABSTRACTWhereas fossil turtle eggs have a near global distribution and range from Middle Jurassic to Pleistocene, they are rarely documented from the Mesozoic of Gondwana. Here, we report three fossil turtle eggs from the Upper Cretaceous (Campanian) of the Morondava Basin, Madagascar. The spherical eggs range in size from 33.5 to 35.5 mm and have an average eggshell thickness of 440 µm. They can be confidently identified as rigid-shelled turtle eggs by the presence of tightly packed shell units composed of radiating acicular crystals and a shell unit height to width ratio of 2:1. Lack of associated skeletal remains precludes taxonomic identification of the eggs. Although a large vertebrate fauna has been reported from the Upper Cretaceous of Madagascar, these specimens are the first eggs from the Mesozoic of the island.SUPPLEMENTAL DATA—Supplemental materials are available for this article for free at www.tandfonline.com/UJVP
DOI: 10.6084/m9.figshare.1568176
title: Ocular Neuromyotonia Associated with Chronic Inflammatory Demyelinating Polyneuropathy

description: Ocular neuromyotonia (ONM) is a neuro-ophthalmic disorder characterized by episodic diplopia caused by contraction of one or more ocular muscles due to spontaneous excitation of the respective ocular motor nerve. We report a patient whose ocular neuromyotonia arose in the setting of a subacute demyelinating polyneuropathy consistent with chronic inflammatory demyelinating polyneuropathy (CIDP) and subsequently resolved following the initiation of intravenous immunoglobulin (IVIg) for her neuropathy. Our patient provides additional evidence towards the role of demyelination and ephaptic neurotransmission in ocular neuromyotonia and also represents the first reported case of ocular neuromyotonia associated with a systemic neurological condition.
DOI: 10.6084/m9.figshare.1568176.v2
title: Ocular Neuromyotonia Associated with Chronic Inflammatory Demyelinating Polyneuropathy

description: Ocular neuromyotonia (ONM) is a neuro-ophthalmic disorder characterized by episodic diplopia caused by contraction of one or more ocular muscles due to spontaneous excitation of the respective ocular motor nerve. We report a patient whose ocular neuromyotonia arose in the setting of a subacute demyelinating polyneuropathy consistent with chronic inflammatory demyelinating polyneuropathy (CIDP) and subsequently resolved following the initiation of intravenous immunoglobulin (IVIg) for her neuropathy. Our patient provides additional evidence towards the role of demyelination and ephaptic neurotransmission in ocular neuromyotonia and also represents the first reported case of ocular neuromyotonia associated with a systemic neurological condition.
DOI: 10.6084/m9.figshare.1568176.v1
title: Ocular Neuromyotonia Associated with Chronic Inflammatory Demyelinating Polyneuropathy

description: Ocular neuromyotonia (ONM) is a neuro-ophthalmic disorder characterized by episodic diplopia caused by contraction of one or more ocular muscles due to spontaneous excitation of the respective ocular motor nerve. We report a patient whose ocular neuromyotonia arose in the setting of a subacute demyelinating polyneuropathy consistent with chronic inflammatory demyelinating polyneuropathy (CIDP) and subsequently resolved following the initiation of intravenous immunoglobulin (IVIg) for her neuropathy. Our patient provides additional evidence towards the role of demyelination and ephaptic neurotransmission in ocular neuromyotonia and also represents the first reported case of ocular neuromyotonia associated with a systemic neurological condition.
DOI: 10.26030/8mfb-wa73
title: Immune responses to the in vitro LPS assault engineered in the spaceflight multi-omics study

description: Microgravity alters the immune response to in vitro LPS assault engineered in spaceflight: A multi-omics study Microgravity can facilitate creation of a potent environment for opportunistic infection by augmenting virulence and suppressing the host defense. Presumably, extraterrestrial infection may trigger potentially novel bionetworks different from the terrestrial equivalent, which could only be probed by investigating the host-pathogen relationship with minimum terrestrial bias. Towards this objective, we strategically engineered a cell culture module equipped with a feedback controlled semi-automated platform to expose human endothelial cells to lipopolysaccharide (LPS). The assay was carried out in the STS-135 space shuttle, and a concurrent ground study constituted the baseline. Transcriptomic investigation revealed an immune blunting in microgravity; Lbp, MyD88 and MD-2 failed to encode proteins responsible for early LPS uptake. Longer exposure results implied that there was a delayed response, potentially ineffectual in preventing pathogens from opportunistically modulating the infection network. Lack of recruitment of growth factors and a debilitated apoptosome supported this potential explanation. Certain cytokines, such as IL-6 and IL-8, surged in response to LPS insult in microgravity. Contrasting expressions of B2M, TIMP-1 and VEGRs suggested impaired pro-survival adaptation and healing mechanisms. The susceptibility of oxidative stress and immune regulation to microgravity compelled further investigation of the respective microRNA modulators such as miR-200a and miR-146b. These miRNAs were expressed differently in response to LPS assaults in different gravitational limits. In conclusion, despite a serious drawback attributed to the small sample size, we delineated some of the important aspects of the extraterrestrial etiology; more comprehensive follow up studies are warranted. Present study though compromised by the small sample size was able to shade lights on several aspects of immunological responses to the endotoxic assault mediated by uG. Implementing the host-pathogen interactions in the spaceflight and subsequently lysing the cells onboard presented the critical distinguishing features of the present study from the past reports. We identified the CCM of Tissue Genesis, Inc., HI as the suitable hardware system to carry out the experiment in the spaceflight. CCM is an automated, feedback controlled module that can concurrently support 24 bioreactors following protocols exclusively programmed for individual bioreactor. For this experiment we use samples EA41, EA 47, EA45, and EA155 that were exposed to LPS for 4 hours. Samples EA123, EA165, EA127, EA126 were exposed to LPS for 8Hrs. Samples EA33, EA 125, EA79 and EA 39 were controls in this experiment.
DOI: 10.6084/m9.figshare.1568167.v2
title: Lysosomal iron liberation is responsible for the vulnerability of brain microglial cells to iron oxide nanoparticles: comparison with neurons and astrocytes

description: Iron oxide nanoparticles (IONPs) are used for various biomedical and neurobiological applications. Thus, detailed knowledge on the accumulation and toxic potential of IONPs for the different types of brain cells is highly warranted. Literature data suggest that microglial cells are more vulnerable towards IONP exposure than other types of brain cells. To investigate the mechanisms involved in IONP-induced microglial toxicity, we applied fluorescent dimercaptosuccinate-coated IONPs to primary cultures of microglial cells. Exposure to IONPs for 6 h caused a strong concentration-dependent increase in the microglial iron content which was accompanied by a substantial generation of reactive oxygen species (ROS) and by cell toxicity. In contrast, hardly any ROS staining and no loss in cell viability were observed for cultured primary astrocytes and neurons although these cultures accumulated similar specific amounts of IONPs than microglia. Co-localization studies with lysotracker revealed that after 6 h of incubation in microglial cells, but not in astrocytes and neurons, most IONP fluorescence was localized in lysosomes. ROS formation and toxicity in IONP-treated microglial cultures were prevented by neutralizing lysosomal pH by the application of NH<sub>4</sub>Cl or Bafilomycin A1 and by the presence of the iron chelator 2,2′-bipyridyl. These data demonstrate that rapid iron liberation from IONPs at acidic pH and iron-catalyzed ROS generation are involved in the IONP-induced toxicity of microglia and suggest that the relative resistance of astrocytes and neurons against acute IONP toxicity is a consequence of a slow mobilization of iron from IONPs in the lysosomal degradation pathway.
DOI: 10.6084/m9.figshare.1568167
title: Lysosomal iron liberation is responsible for the vulnerability of brain microglial cells to iron oxide nanoparticles: comparison with neurons and astrocytes

description: Iron oxide nanoparticles (IONPs) are used for various biomedical and neurobiological applications. Thus, detailed knowledge on the accumulation and toxic potential of IONPs for the different types of brain cells is highly warranted. Literature data suggest that microglial cells are more vulnerable towards IONP exposure than other types of brain cells. To investigate the mechanisms involved in IONP-induced microglial toxicity, we applied fluorescent dimercaptosuccinate-coated IONPs to primary cultures of microglial cells. Exposure to IONPs for 6 h caused a strong concentration-dependent increase in the microglial iron content which was accompanied by a substantial generation of reactive oxygen species (ROS) and by cell toxicity. In contrast, hardly any ROS staining and no loss in cell viability were observed for cultured primary astrocytes and neurons although these cultures accumulated similar specific amounts of IONPs than microglia. Co-localization studies with lysotracker revealed that after 6 h of incubation in microglial cells, but not in astrocytes and neurons, most IONP fluorescence was localized in lysosomes. ROS formation and toxicity in IONP-treated microglial cultures were prevented by neutralizing lysosomal pH by the application of NH<sub>4</sub>Cl or Bafilomycin A1 and by the presence of the iron chelator 2,2′-bipyridyl. These data demonstrate that rapid iron liberation from IONPs at acidic pH and iron-catalyzed ROS generation are involved in the IONP-induced toxicity of microglia and suggest that the relative resistance of astrocytes and neurons against acute IONP toxicity is a consequence of a slow mobilization of iron from IONPs in the lysosomal degradation pathway.
DOI: 10.6084/m9.figshare.1568144
title: Synthesis, crystal structure, redox behavior and DNA-binding properties of a series of copper(II) complexes with two new carboxamide derivatives

description: Four mononuclear copper(II) complexes of two new carboxamide derivatives formulated as [Cu(L<sup>1</sup>)<sub>2</sub>](ClO<sub>4</sub>)<sub>2</sub> (<b>1a</b>), [Cu(L<sup>1</sup>)<sub>2</sub>](NO<sub>3</sub>)<sub>2</sub> (<b>1b</b>), [Cu(L<sup>2</sup>)<sub>2</sub>(H<sub>2</sub>O)<sub>2</sub>](ClO<sub>4</sub>)<sub>2</sub> (<b>2a</b>) and [Cu(L<sup>2</sup>)<sub>2</sub>(H<sub>2</sub>O)](NO<sub>3</sub>)<sub>2</sub> (<b>2b</b>) have been isolated in pure form from the reaction of <b>L</b><sup><b>1</b></sup> and <b>L</b><sup><b>2</b></sup> [where <b>L</b><sup><b>1</b></sup> = <i>N</i>-(furan-2-ylmethyl)-2-pyridinecarboxamide and <b>L</b><sup><b>2</b></sup> = <i>N</i>-(thiophen-2-ylmethyl)-2-pyridinecarboxamide] with copper(II) salts of perchlorate and nitrate. All the complexes were characterized by physico-chemical and spectroscopic tools along with single crystal X–ray diffraction studies. The structural analyses showed that <b>1</b> is monomeric of square planar geometry with copper(II) chelated by two <b>L</b><sup><b>1</b></sup> ligands. Complexes <b>2</b> differs in coordination geometry, being octahedral and distorted square pyramidal. Two <b>L</b><sup><b>2</b></sup> ligands occupy the equatorial positions of the octahedral <b>2a</b> and the basal sites of the pyramidal <b>2b</b>, with water molecules that complete the coordination sphere in each case. Electrochemical studies using cyclic voltammetry showed a reversible redox behavior of the copper(II) in <b>1</b> and <b>2</b>. The electronic spectroscopic behavior and the trend of one electron equivalent redox potential corresponding to a Cu<sup>II</sup>/Cu<sup>I</sup> couple have also been confirmed by DFT calculations. The spectroscopic and viscosity measurement study in tris-HCl buffer suggested an intercalative interaction of <b>1a</b> and <b>2</b> with calf thymus-DNA (CT-DNA) likely due to the stacking between the non-coordinated furan or thiophene chromophore with the base pairs of DNA.