cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.17632/bhjb773yfb
title: Characterization of serotonin-5- HTR1E signaling pathways and its role in cell survival

description: Raw data files for the manuscript "Characterization of serotonin-5-HTR1E signaling pathways and its role in cell survival" published in The FASEB Journal, DOI: 10.1096/fj.202300128R.

5-Hydroxytryptamine receptor 1E (5-HTR1E) is reported to activate cyclic AMP (cAMP) and extracellular-signal related kinases (ERK) pathways via its ligands and binding partners, but the detailed mechanism underlying the serotonin-induced 5-HTR1E signaling is still not known. In the present study, we determined the cellular regulators of ERK and cAMP signaling pathways in response to serotonin-induced 5-HTR1E activation in 5-HTR1E overexpressing HEK293 cells. We found that Pertussis Toxin (PTX) treatment completely reversed the effect of
serotonin-5-HTR1E mediated signaling on cAMP and ERK pathways, confirming the involvement of a Gái-linked cascade. We also observed that GBg and Gq were not associated with 5-HTR1E activation, while blocking protein kinase A (PKA) inhibited ERK signaling only, and had no effect on cAMP. Additionally, serotonin-stimulated ERK1/2 phosphorylation was similar in 5-HTR1E overexpressing, B-arrestin-deficient HEK293 cells and is solely dependent on G protein signaling. siRNA mediated gene knockdown studies in SH-SY5Y cells revealed that the inhibition of 5-HTR1E reduced the expression of cMyc, Cyclin D1, Cyclin E and BCL2 genes which are related to cell cycle regulation and survival. MTT assays showed that 5-HTR1E
knockdown in SHSY-5Y and U118 cells inhibited cell survival significantly. In addition to the signaling mechanism, we also performed RNA-seq analysis in 5-HTR1E overexpressing HEK293 cells and found that 5-HTR1E can regulate the expression of Receptor activity modifying protein 1 (RAMP1), Nuclear receptor 1 (NR4A1) and other Cyclin genes. These findings indicate that serotonin interaction with 5-HTR1E receptor simultaneously activates cAMP and ERK pathway in HEK293 cells and its expression is important for cell survival.
DOI: 10.17632/bhjb773yfb.1
title: Characterization of serotonin-5- HTR1E signaling pathways and its role in cell survival

description: Raw data files for the manuscript "Characterization of serotonin-5-HTR1E signaling pathways and its role in cell survival" published in The FASEB Journal, DOI: 10.1096/fj.202300128R.

5-Hydroxytryptamine receptor 1E (5-HTR1E) is reported to activate cyclic AMP (cAMP) and extracellular-signal related kinases (ERK) pathways via its ligands and binding partners, but the detailed mechanism underlying the serotonin-induced 5-HTR1E signaling is still not known. In the present study, we determined the cellular regulators of ERK and cAMP signaling pathways in response to serotonin-induced 5-HTR1E activation in 5-HTR1E overexpressing HEK293 cells. We found that Pertussis Toxin (PTX) treatment completely reversed the effect of
serotonin-5-HTR1E mediated signaling on cAMP and ERK pathways, confirming the involvement of a Gái-linked cascade. We also observed that GBg and Gq were not associated with 5-HTR1E activation, while blocking protein kinase A (PKA) inhibited ERK signaling only, and had no effect on cAMP. Additionally, serotonin-stimulated ERK1/2 phosphorylation was similar in 5-HTR1E overexpressing, B-arrestin-deficient HEK293 cells and is solely dependent on G protein signaling. siRNA mediated gene knockdown studies in SH-SY5Y cells revealed that the inhibition of 5-HTR1E reduced the expression of cMyc, Cyclin D1, Cyclin E and BCL2 genes which are related to cell cycle regulation and survival. MTT assays showed that 5-HTR1E
knockdown in SHSY-5Y and U118 cells inhibited cell survival significantly. In addition to the signaling mechanism, we also performed RNA-seq analysis in 5-HTR1E overexpressing HEK293 cells and found that 5-HTR1E can regulate the expression of Receptor activity modifying protein 1 (RAMP1), Nuclear receptor 1 (NR4A1) and other Cyclin genes. These findings indicate that serotonin interaction with 5-HTR1E receptor simultaneously activates cAMP and ERK pathway in HEK293 cells and its expression is important for cell survival.
DOI: 10.17632/m4htc543py
title: Data Random Utility Maximisation Model Considering the Information Search Process

description: This dataset and code enable the estimation of the outputs reported in the RUM-DFT model. It includes 20 simulated choice datasets representing the information search process and the RUM-DFT-ISP.R script to replicate the RUM-DFT-ISP values reported in the paper. Additionally, the dataset provides the complete Swiss Metro data and the corresponding code to replicate the outputs of the empirical case study.

If you use this dataset or code in your research, we kindly request that you cite the corresponding paper.

Nova, G., Guevara, C. A., Hess, S., & Hancock, T. O. (2025). A random utility maximisation model considering the information search process. Transportation Research Part B: Methodological, 199, 103264.

For any questions or additional information, please contact us at g.n.nova@tudelft.nl
DOI: 10.17632/m4htc543py.2
title: Data Random Utility Maximisation Model Considering the Information Search Process

description: This dataset and code enable the estimation of the outputs reported in the RUM-DFT model. It includes 20 simulated choice datasets representing the information search process and the RUM-DFT-ISP.R script to replicate the RUM-DFT-ISP values reported in the paper. Additionally, the dataset provides the complete Swiss Metro data and the corresponding code to replicate the outputs of the empirical case study.

If you use this dataset or code in your research, we kindly request that you cite the corresponding paper.

Nova, G., Guevara, C. A., Hess, S., & Hancock, T. O. (2025). A random utility maximisation model considering the information search process. Transportation Research Part B: Methodological, 199, 103264.

For any questions or additional information, please contact us at g.n.nova@tudelft.nl
DOI: 10.15468/dl.8szu5t
title: Occurrence Download

description: A dataset containing 1 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Phoenix canariensis",
 "Country is Malta",
 "HasCoordinate is true"
 ]
}

 The dataset includes 1 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0025231-250711103210423/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.3535/29w-cpy-z97
title: Begonia reniformis Dryand.

description: Digital Specimen for the physical specimen hosted at Natural History Museum Vienna.
DOI: 10.15468/dl.u3hc7x
title: Occurrence Download

description: A dataset containing 103 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Geometry POLYGON((18.24182 50.46303,18.33129 50.46303,18.33129 50.49952,18.24182 50.49952,18.24182 50.46303))",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present"
 ]
}

 The dataset includes 103 records from 7 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0025232-250711103210423/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.gxayg5
title: Occurrence Download

description: A dataset containing 40 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Dontostemon crassifolius"
 ]
}

 The dataset includes 40 records from 11 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0025233-250711103210423/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.nxj2dd
title: Occurrence Download

description: A dataset containing 115 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Dalea phleoides)",
 "HasCoordinate is true",
 "HasGeospatialIssue is false"
 ]
}

 The dataset includes 115 records from 15 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0025234-250711103210423/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.hhyt2j
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Phoenix canariensis",
 "Country is Marshall Islands",
 "HasCoordinate is true"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0025235-250711103210423/datasets/export for details.
DOI: 10.15468/dl.unw5wf
title: Occurrence Download

description: A dataset containing 5 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Lepidium boelckei"
 ]
}

 The dataset includes 5 records from 4 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0025236-250711103210423/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.3535/22x-3xc-jf4
title: Begonia cucullata Willd.

description: Digital Specimen for the physical specimen hosted at Natural History Museum Vienna.
DOI: 10.15468/dl.253gra
title: Occurrence Download

description: A dataset containing 48 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Phoenix canariensis",
 "Country is Mexico",
 "HasCoordinate is true"
 ]
}

 The dataset includes 48 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0025238-250711103210423/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.kw7vpu
title: Occurrence Download

description: A dataset containing 1 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Scaphiodon thomassi"
 ]
}

 The dataset includes 1 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0025237-250711103210423/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.5281/zenodo.15991057
title: SPINDR: Small molecule Protein Interaction Dataset, Refined

description: The 'raw' SPINDR dataset with protein pockets given as CIF and ligands as SDF files.
DOI: 10.15468/dl.cr985a
title: Occurrence Download

description: A dataset containing 7773 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Geranium robertianum",
 "Geometry POLYGON((-8.00174339329464 54.1998526673513, 0.202120938926891 54.1998526673513, 0.202120938926891 61.2628565887411, -8.00174339329464 61.2628565887411, -8.00174339329464 54.1998526673513))",
 "CoordinateUncertaintyInMeters is 0,101",
 "HasCoordinate is true",
 "HasGeospatialIssue is false"
 ]
}

 The dataset includes 7773 records from 50 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0025239-250711103210423/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.3535/n61-sl2-n44
title: Begonia fischeri Schrank

description: Digital Specimen for the physical specimen hosted at Natural History Museum Vienna.
DOI: 10.15468/dl.v8auh6
title: Occurrence Download

description: A dataset containing 1 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Phoenix canariensis",
 "Country is Nicaragua",
 "HasCoordinate is true"
 ]
}

 The dataset includes 1 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0025240-250711103210423/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.hdsqyv
title: Occurrence Download

description: A dataset containing 7 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Ivania juncalensis"
 ]
}

 The dataset includes 7 records from 4 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0025241-250711103210423/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.pxr4dh
title: Occurrence Download

description: A dataset containing 10310 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Malaclemys"
 ]
}

 The dataset includes 10310 records from 92 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0025242-250711103210423/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.ssxem2
title: Occurrence Download

description: A dataset containing 5 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Matthiola euboea"
 ]
}

 The dataset includes 5 records from 3 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0025244-250711103210423/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.eb66x3
title: Occurrence Download

description: A dataset containing 10368 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Dalea purpurea)",
 "HasCoordinate is true",
 "HasGeospatialIssue is false"
 ]
}

 The dataset includes 10368 records from 126 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0025243-250711103210423/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.ytx988
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Phoenix canariensis",
 "Country is Niue",
 "HasCoordinate is true"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0025245-250711103210423/datasets/export for details.
DOI: 10.15468/dl.hjr6zb
title: Occurrence Download

description: A dataset containing 194 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Zilla macroptera"
 ]
}

 The dataset includes 194 records from 36 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0025246-250711103210423/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.cc4hrp
title: Occurrence Download

description: A dataset containing 1 species occurrences available in GBIF matching the query:
{
 "and" : [
 "HasGeospatialIssue is false",
 "HasCoordinate is true",
 "OccurrenceStatus is Present",
 "BasisOfRecord is one of (Human Observation, Machine Observation, Occurrence evidence, Observation)",
 "TaxonKey is one of (Pipilo maculatus)",
 "Country is one of (Åland Islands, Albania, Andorra, Austria, Belarus, Belgium, Bosnia and Herzegovina, Bulgaria, Croatia, Czechia, Denmark, Estonia, Faroe Islands, Finland, France, Germany, Gibraltar, Greece, Guernsey, Holy See, Hungary, Iceland, Ireland, Isle of Man, Italy, Jersey, Latvia, Liechtenstein, Lithuania, Luxembourg, Malta, Moldova, Republic of, Monaco, Montenegro, Netherlands, North Macedonia, Norway, Poland, Portugal, Romania, Russian Federation, San Marino, Serbia, Slovakia, Slovenia, Spain, Svalbard and Jan Mayen, Sweden, Switzerland, Ukraine, United Kingdom of Great Britain and Northern Ireland)"
 ]
}

 The dataset includes 1 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0025248-250711103210423/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.3535/gep-558-1a6
title: Lecidea tragorum Zahlbr.

description: Digital Specimen for the physical specimen hosted at Natural History Museum Vienna.
DOI: 10.15468/dl.cstb3p
title: Occurrence Download

description: A dataset containing 233 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Osteochilus microcephalus"
 ]
}

 The dataset includes 233 records from 25 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0025247-250711103210423/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.un88sc
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Mirabilis jalapa",
 "Country is Nauru",
 "HasCoordinate is true"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0025250-250711103210423/datasets/export for details.
DOI: 10.15468/dl.9fsfav
title: Occurrence Download

description: A dataset containing 7 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Phoenix canariensis",
 "Country is Peru",
 "HasCoordinate is true"
 ]
}

 The dataset includes 7 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0025249-250711103210423/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.5284/1090477
title: Rapa Nui Landscapes of Construction Project Digital Archive

description: The archaeology of Rapa Nui (Easter Island) is dominated by the large stone statues (moai) that date to c. 1000-1600AD. The majority of moai are sculpted from volcanic tuff quarried from the inner and outer crater of Rano Raraku, an extinct volcano situated in the south-east of the island. This archive contains data collated by the Rapa Nui Landscapes of Construction Project between 2008 and 2015. The research was primarily funded by the Arts and Humanities Research Council and was aimed at developing new interpretations of the organisation and meaning of the monumental construction activities on Rapa Nui. The Rapa Nui Landscapes of Construction Project (LOC) archive comprises of inter-related documents, drawings, photographs and survey data generated between 2008 and 2015. The digital archive contains digitised versions of paper records as well as electronic files generated during the course of the project.
DOI: 10.15468/dl.77mzzq
title: Occurrence Download

description: A dataset containing 512 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Lepidium aschersonii"
 ]
}

 The dataset includes 512 records from 21 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0025251-250711103210423/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.3535/jzv-cdt-y17
title: Strickeria kochii Körb.

description: Digital Specimen for the physical specimen hosted at Natural History Museum Vienna.
DOI: 10.15468/dl.3ea6kj
title: Occurrence Download

description: A dataset containing 6309 species occurrences available in GBIF matching the query:
{
 "and" : [
 "CollectionKey is one of (741f12d3-ebfc-48e7-9d8c-180d41b0a582)",
 "EventDate 1842-07-28-2023-09-22",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "Geometry POLYGON ((-73.267822265625 46.26344299316406, -73.32275390625 46.21784973144531, -73.443603515625 46.17982864379883, -73.685302734375 46.11894226074219, -73.76220703125 46.080848693847656, -73.828125 46.02748489379883, -73.883056640625 45.92823028564453, -73.916015625 45.821144104003906, -73.93798828125 45.72152328491211, -73.927001953125 45.6370849609375, -73.883056640625 45.529441833496094, -73.817138671875 45.43701171875, -73.773193359375 45.383018493652344, -73.707275390625 45.3289794921875, -73.399658203125 45.16654586791992, -73.1689453125 45.065757751464844, -73.0810546875 45.04248046875, -72.982177734375 45.04248046875, -72.70751953125 45.05800247192383, -72.22412109375 45.14330291748047, -71.9384765625 45.1975212097168, -71.91650390625 45.2362174987793, -71.883544921875 45.27488708496094, -71.78466796875 45.367584228515625, -71.6748046875 45.46013259887695, -71.65283203125 45.50634765625, -71.65283203125 45.529441833496094, -71.78466796875 45.752193450927734, -72.059326171875 45.92058563232422, -72.388916015625 46.057987213134766, -72.59765625 46.14939498901367, -72.608642578125 46.14939498901367, -72.66357421875 46.1341667175293, -72.696533203125 46.10371017456055, -72.740478515625 46.057987213134766, -72.7734375 46.02748489379883, -72.7734375 46.01222610473633, -72.8173828125 45.97406005859375, -72.850341796875 45.93587112426758, -72.850341796875 45.92823028564453, -72.861328125 45.92058563232422, -73.267822265625 46.26344299316406))"
 ]
}

 The dataset includes 6309 records from 3 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0025252-250711103210423/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.az6weg
title: Occurrence Download

description: A dataset containing 148 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Phoenix canariensis",
 "Country is Portugal",
 "HasCoordinate is true"
 ]
}

 The dataset includes 148 records from 6 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0025254-250711103210423/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.kh37n6
title: Occurrence Download

description: A dataset containing 8801 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Desmanthus illinoensis, Desmanthus illinoensis)",
 "HasCoordinate is true",
 "HasGeospatialIssue is false"
 ]
}

 The dataset includes 8801 records from 102 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0025253-250711103210423/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.djdx5b
title: Occurrence Download

description: A dataset containing 891 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Trifolium uniflorum L."
 ]
}

 The dataset includes 891 records from 73 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0021227-230810091245214/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.nqfp2l
title: Occurrence Download

description: A dataset containing 8 species occurrences available in GBIF matching the query:
{
 "DatasetKey" : [
 "is (Table 1) Proportion of Toxoplasma gondii seropositive arctic foxes (Alopex lagopus) by age group and geographic area"
 ]
}

 The dataset includes 8 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0027675-180508205500799/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.reinvt
title: Occurrence Download

description: A dataset containing 8 species occurrences available in GBIF matching the query:
{
 "DatasetKey" : [
 "is (Table 1) Proportion of Toxoplasma gondii seropositive arctic foxes (Alopex lagopus) by age group and geographic area"
 ]
}

 The dataset includes 8 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0006097-160910150852091/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.