cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.22032545
title: Supplementary Material for: Achievement of Complete Response and Drug-free Status by Atezolizumab Plus Bevacizumab Combined with or without Curative Conversion in Patients with Transarterial Chemoembolization-Unsuitable, Intermediate-stage Hepatocellular Carcinoma: A Multicenter Proof-of-Concept Study

description: Introduction: Atezolizumab plus bevacizumab therapy is extremely effective in the treatment of intermediate-stage hepatocellular carcinoma (HCC), with a response rate of 44%, as reported in the IMbrave150 trial. When tumor shrinkage is obtained, achieving complete response (CR) is possible in many cases using curative conversion with resection, ablation, or super selective transarterial chemoembolization (TACE) with curative intent. This concept, i.e., curative conversion by combining systemic therapy and locoregional therapy, has not been reported before. This multicenter proof-of-concept study was conducted to show the value of curative conversion in immunotherapy-treated intermediate-stage HCC meeting TACE-unsuitable criteria. Methods: This study included 110 consecutive Child-Pugh A patients who received atezolizumab plus bevacizumab as first-line treatment for unresectable and TACE-unsuitable intermediate-stage HCC at seven centers in Japan. CR rate, drug-free rate, time to CR, change in liver function, efficacy in positron emission tomography (PET)-positive HCC, progression-free survival (PFS), and overall survival (OS) were assessed in patients who achieved CR using resection, ablation, super selective TACE with curative intent following atezolizumab plus bevacizumab or atezolizumab plus bevacizumab alone. Results: Clinical or pathological CR was achieved in 38 patients (35%) (median observation period: 21.2 months). The modalities of curative conversion in 35 patients were as follows: resection, 7; ablation, 13; and superselective TACE, 15. Three patients achieved clinical CR with atezolizumab plus bevacizumab therapy alone. Among the 38 CR patients, 25 achieved drug-free status. PFS was not reached, and three patients experienced recurrence after reaching CR. Regarding OS, there were no deaths in any of the CR patients. The albumin-bilirubin score did not deteriorate after locoregional therapy or resection. Of seven PET-positive patients who achieved CR with atezolizumab plus bevacizumab followed by curative conversion, five achieved drug-free status. Discussion/Conclusion: The achievement of CR rate by curative conversion in patients treated with atezolizumab plus bevacizumab as the preceding therapy for unresectable and TACE-unsuitable intermediate-stage HCC was 35%. Overall, 23% of patients achieved drug-free status and no recurrence was observed from this patient subgroup with CR and drug free status. Thus, achieving CR and/or drug-free status should be a therapeutic goal for patients with intermediate-stage HCC without vascular invasion or extrahepatic spread.
DOI: 10.58119/ulg/uowrsl/3gdwzg
title: mp-4782.json

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DOI: 10.58119/ulg/uowrsl/inubyl
title: mp-29138.json

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DOI: 10.58119/ulg/uowrsl/javgwf
title: mp-560791.json

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DOI: 10.58119/ulg/uowrsl/ojnscg
title: mp-7457.json

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DOI: 10.58119/ulg/uowrsl/lneubx
title: mp-14206.json

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DOI: 10.58119/ulg/uowrsl/jqsjx4
title: mp-7027.json

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DOI: 10.58119/ulg/uowrsl/sr35qb
title: mp-552488.json

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DOI: 10.58119/ulg/uowrsl/xjkm0y
title: mp-37906.json

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DOI: 10.58119/ulg/uowrsl/3q9zqh
title: mp-3982.json

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DOI: 10.58119/ulg/uowrsl/xmsbaa
title: mp-27294.json

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DOI: 10.58119/ulg/uowrsl/4jy4bu
title: mp-7421.json

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DOI: 10.58119/ulg/uowrsl/se1tyb
title: mp-7575.json

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DOI: 10.58119/ulg/uowrsl/arocoz
title: mp-3481.json

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DOI: 10.58119/ulg/uowrsl/19w6vd
title: mp-8283.json

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DOI: 10.58119/ulg/uowrsl/kqn3ev
title: mp-8175.json

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DOI: 10.58119/ulg/uowrsl/vpo5en
title: mp-10985.json

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DOI: 10.5281/zenodo.7756342
title: Assessment of the spatial extent of local active noise control - dataset

description: Experiment setup, data and supplementary scripts for the listening experiment "Assessment of the spatial extent of local active noise control" in Feb. 2023 at the Institute of Electronic Music and Acoustics in Graz, Austria A listening experiment has been conducted, trying to find the spatial extents of local active noise control (ANC). Participants were instructed to move their heads along the x-axis or rotate clock- and counterclockwise (yaw). A button had to be pressed if the perceived zone of comfort is left, and the current position was recorded. This task was repeated for different controlled bandwidths, signals and source directions. Additionally, scripts to generate the ANC filters, a brief statistical analysis and recordings at several positions for different stimuli/conditions are provided.
DOI: 10.58119/ulg/uowrsl/oh71cz
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DOI: 10.58119/ulg/uowrsl/ravfjc
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DOI: 10.58119/ulg/uowrsl/iesiie
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DOI: 10.58119/ulg/uowrsl/dlcd0d
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DOI: 10.58119/ulg/uowrsl/g6pzt7
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DOI: 10.58119/ulg/uowrsl/ayxyaf
title: mp-15704.json

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DOI: 10.58119/ulg/uowrsl/klmqbc
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DOI: 10.58119/ulg/uowrsl/6xydua
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DOI: 10.58119/ulg/uowrsl/nrt1pp
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DOI: 10.58119/ulg/uowrsl/vpqn25
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DOI: 10.58119/ulg/uowrsl/cm0nq1
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DOI: 10.58119/ulg/uowrsl/fej6zz
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DOI: 10.58119/ulg/uowrsl/ikabcp
title: mp-22898.json

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DOI: 10.58119/ulg/uowrsl/i4nvwq
title: standard_froelich_data_valence

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DOI: 10.58119/ulg/uowrsl/1qaof6
title: standard_froelich_data_conduction

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DOI: 10.58119/ulg/uowrsl/f20bcb
title: standard_feynman_data_valence

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DOI: 10.58119/ulg/uowrsl/zgoj9s
title: standard_feynman_data_conduction

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DOI: 10.58119/ulg/uowrsl/uh2j3h
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DOI: 10.6084/m9.figshare.22320685.v1
title: Data analysis of herbicide experiment (2012-2018)

description: Data and R script accompanying the manuscript: <br> Lugar, R., Nelson, C.R., Wagner, V.: "Efficacy and non-target effects of herbicides in foothills grassland restoration are short-lived" <br> Meta-data (column names): <br> Comments: Comments Cover: Percentage foliar cover for each species in a plot Cover_bare_soil: Cover exposed soil (not included in the analysis) Cover_bryophyte_lichens: Cover of lichen and bryophyte layer (not included in the analysis) Cover_detritus: Cover of litter layer (not included in the analysis) Cover_herb_layer: Cover of herbaceous layer (not included in the analysis) Cover_shrub_layer: Cover of shrub layer (not included in the analysis) Data_collected_by: Names of data collectors Date: Date of data collection growth_habit: Species growth form (monocot, dicot) Layer: Vegetation layer (herbaceous or shrub layer) Longevity: Species longevity (annual, perennial) Max_height_detritus: Max. height of litter layer (not included in the analysis) Max_height_herb_layer: Max. height of herbaceous layer (not included in the analysis) Max_height_shrub_layer: Max. height of shrub layer (not included in the analysis) Plot: Plot ID Plot_Size: Plot size Project: Project name Site.short: Abbreviation for site Site: Name of site Species: Species name Status: Species status (native or non-native) Treatment: Treatment application Year: Year of data collection
DOI: 10.58119/ulg/uowrsl/ojoi0k
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DOI: 10.58119/ulg/uowrsl/yczhwy
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DOI: 10.58119/ulg/uowrsl/dklv3s
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DOI: 10.58119/ulg/uowrsl/omc2eb
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DOI: 10.58119/ulg/uowrsl/a2bfpl
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DOI: 10.58119/ulg/uowrsl/9wtnz6
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DOI: 10.58119/ulg/uowrsl/cn05mo
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DOI: 10.58119/ulg/uowrsl/pikjlx
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DOI: 10.58119/ulg/uowrsl/ms4pz5
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DOI: 10.58119/ulg/uowrsl/lyywwm
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DOI: 10.58119/ulg/uowrsl/ltwqaq
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DOI: 10.58119/ulg/uowrsl/xa40if
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DOI: 10.58119/ulg/uowrsl/u8j4qp
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DOI: 10.58119/ulg/uowrsl/fjmygk
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DOI: 10.58119/ulg/uowrsl/jlcep0
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DOI: 10.58119/ulg/uowrsl/bmqly8
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DOI: 10.58119/ulg/uowrsl/uvf06y
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DOI: 10.58119/ulg/uowrsl/bbpcdk
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DOI: 10.58119/ulg/uowrsl/ka8ptk
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DOI: 10.58119/ulg/uowrsl/a3med0
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DOI: 10.58119/ulg/uowrsl/jt2jyz
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DOI: 10.58119/ulg/uowrsl/v8tqrp
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DOI: 10.58119/ulg/uowrsl/aqzri0
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DOI: 10.58119/ulg/uowrsl/6kjl4y
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DOI: 10.58119/ulg/uowrsl/8cqmz3
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DOI: 10.58119/ulg/uowrsl/dkqwqk
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DOI: 10.58119/ulg/uowrsl/lyoo2o
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DOI: 10.58119/ulg/uowrsl/z5hcts
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DOI: 10.58119/ulg/uowrsl/tsqnpm
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DOI: 10.58119/ulg/uowrsl/ryeuao
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DOI: 10.58119/ulg/uowrsl/oisejq
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