cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.17912995.v1
title: Additional file 1 of Evidence-based cardiovascular magnetic resonance cost-effectiveness calculator for the detection of significant coronary artery disease

description: Additional file 1. Users can enter model inputs that relate to their population of interest (e.g., age, probability of patient having treatable CAD), imaging strategies (sensitivity, specificity, cost), treatments (e.g., effectiveness, risks, and costs of revascularization procedures), and other variables (e.g., willingness-to-pay for health, discount rate), to then see how these collection of inputs translates to lifetime per-person net monetary benefit (i.e., an overall metric of value using cost-effectiveness analysis), lifetime discounted quality-adjusted life years (i.e., the main measure of effectiveness), and lifetime discounted costs. Default input values for the US are provided in the model file.
DOI: 10.6084/m9.figshare.16779516
title: Additional file 1 of Diagnostic utility of next-generation sequencing-based panel testing in 543 patients with suspected skeletal dysplasia

description: Additional file 1. Variants in non-diagnostic cases with suspicious VUSes.
DOI: 10.6084/m9.figshare.16779519
title: Additional file 2 of Diagnostic utility of next-generation sequencing-based panel testing in 543 patients with suspected skeletal dysplasia

description: Additional file 2. Diagnostic prenatal variants.
DOI: 10.6084/m9.figshare.16779519.v1
title: Additional file 2 of Diagnostic utility of next-generation sequencing-based panel testing in 543 patients with suspected skeletal dysplasia

description: Additional file 2. Diagnostic prenatal variants.
DOI: 10.6084/m9.figshare.16779516.v1
title: Additional file 1 of Diagnostic utility of next-generation sequencing-based panel testing in 543 patients with suspected skeletal dysplasia

description: Additional file 1. Variants in non-diagnostic cases with suspicious VUSes.
DOI: 10.6084/m9.figshare.16779522
title: Additional file 3 of Diagnostic utility of next-generation sequencing-based panel testing in 543 patients with suspected skeletal dysplasia

description: Additional file 3. Panel gene content and targeted non-coding variants.
DOI: 10.6084/m9.figshare.16779522.v1
title: Additional file 3 of Diagnostic utility of next-generation sequencing-based panel testing in 543 patients with suspected skeletal dysplasia

description: Additional file 3. Panel gene content and targeted non-coding variants.
DOI: 10.6084/m9.figshare.16575738
title: Additional file 3 of Holling meets habitat selection: functional response of large herbivores revisited

description: Additional file 3. Vignette to R package FunResp.
DOI: 10.6084/m9.figshare.16575738.v1
title: Additional file 3 of Holling meets habitat selection: functional response of large herbivores revisited

description: Additional file 3. Vignette to R package FunResp.
DOI: 10.6084/m9.figshare.19194242
title: Additional file 1 of First-degree relationships and genotyping errors deciphered by a high-density SNP array in a Duroc × Iberian pig cross

description: Additional file 1.
DOI: 10.6084/m9.figshare.19194242.v1
title: Additional file 1 of First-degree relationships and genotyping errors deciphered by a high-density SNP array in a Duroc × Iberian pig cross

description: Additional file 1.
DOI: 10.6084/m9.figshare.19194245.v1
title: Additional file 2 of First-degree relationships and genotyping errors deciphered by a high-density SNP array in a Duroc × Iberian pig cross

description: Additional file 2.
DOI: 10.6084/m9.figshare.19194245
title: Additional file 2 of First-degree relationships and genotyping errors deciphered by a high-density SNP array in a Duroc × Iberian pig cross

description: Additional file 2.
DOI: 10.6084/m9.figshare.19194257
title: Additional file 1 of Mechanisms of magnoliae cortex on treating sarcopenia explored by GEO gene sequencing data combined with network pharmacology and molecular docking

description: Additional file 1: Table S1. Differentially expressed genes related to sarcopenia in old people of GEO series.Table S2. Integrated data of sarcopenia related pathogenic genes. Table S3. Result of GO enrichment analysis for sarcopenia related pathogenic gene products. Table S4. Result of KEGG enrichment analysis for sarcopenia related pathogenic gene products. Table S5. Result of targets prediction of MC. Table S6. Composite targets of MC and sarcopenia. Table S7. Result of GO enrichment analysis for composite targets of MC and sarcopenia. Table S8. Result of KEGG enrichment analysis for composite targets of MC and sarcopenia. Table S9. Core proteins of MC-sarcopenia composite targets. Table S10. The affinity energy of Honokiol-AKT1. Table S11. The affinity energy of Magnolol-AKT1. Table S12. The affinity energy of Honokiol-EGFR. Table S13. The affinity energy of Magnolol-EGFR. Table S14. The affinity energy of Honokiol-INS. Table S15. The affinity energy of Magnolol-INS. Table S16. The affinity energy of Obovatol-PIK3CA. Figure S1. Sarcopenia related pathogenic gene products involve in EGFR tyrosine kinase inhibitor resistance (hsa01521). Figure S2. Sarcopenia related pathogenic gene products involve in endocrine resistance (hsa01522). Figure S3. Sarcopenia related pathogenic gene products involve in longevity regulating pathway (hsa04211). Figure S4. The GO and KEGG analysis of core sarcopenia-related pathogenic proteins. Figure S5. Core sarcopenia related pathogenic gene products involve in PI3K-Akt signaling pathway (hsa04151). Figure S6. Core sarcopenia related pathogenic gene products involve in longevity regulating pathway (hsa04213).
DOI: 10.6084/m9.figshare.19194257.v1
title: Additional file 1 of Mechanisms of magnoliae cortex on treating sarcopenia explored by GEO gene sequencing data combined with network pharmacology and molecular docking

description: Additional file 1: Table S1. Differentially expressed genes related to sarcopenia in old people of GEO series.Table S2. Integrated data of sarcopenia related pathogenic genes. Table S3. Result of GO enrichment analysis for sarcopenia related pathogenic gene products. Table S4. Result of KEGG enrichment analysis for sarcopenia related pathogenic gene products. Table S5. Result of targets prediction of MC. Table S6. Composite targets of MC and sarcopenia. Table S7. Result of GO enrichment analysis for composite targets of MC and sarcopenia. Table S8. Result of KEGG enrichment analysis for composite targets of MC and sarcopenia. Table S9. Core proteins of MC-sarcopenia composite targets. Table S10. The affinity energy of Honokiol-AKT1. Table S11. The affinity energy of Magnolol-AKT1. Table S12. The affinity energy of Honokiol-EGFR. Table S13. The affinity energy of Magnolol-EGFR. Table S14. The affinity energy of Honokiol-INS. Table S15. The affinity energy of Magnolol-INS. Table S16. The affinity energy of Obovatol-PIK3CA. Figure S1. Sarcopenia related pathogenic gene products involve in EGFR tyrosine kinase inhibitor resistance (hsa01521). Figure S2. Sarcopenia related pathogenic gene products involve in endocrine resistance (hsa01522). Figure S3. Sarcopenia related pathogenic gene products involve in longevity regulating pathway (hsa04211). Figure S4. The GO and KEGG analysis of core sarcopenia-related pathogenic proteins. Figure S5. Core sarcopenia related pathogenic gene products involve in PI3K-Akt signaling pathway (hsa04151). Figure S6. Core sarcopenia related pathogenic gene products involve in longevity regulating pathway (hsa04213).
DOI: 10.6084/m9.figshare.19194266.v1
title: Additional file 1 of Evaluating the cytotoxicity and pathogenicity of multi-walled carbon nanotube through weighted gene co-expression network analysis: a nanotoxicogenomics study

description: Additional file 1.
DOI: 10.6084/m9.figshare.19194266
title: Additional file 1 of Evaluating the cytotoxicity and pathogenicity of multi-walled carbon nanotube through weighted gene co-expression network analysis: a nanotoxicogenomics study

description: Additional file 1.
DOI: 10.6084/m9.figshare.19194278
title: Additional file 5 of Evaluating the cytotoxicity and pathogenicity of multi-walled carbon nanotube through weighted gene co-expression network analysis: a nanotoxicogenomics study

description: Additional file 5.
DOI: 10.6084/m9.figshare.19194278.v1
title: Additional file 5 of Evaluating the cytotoxicity and pathogenicity of multi-walled carbon nanotube through weighted gene co-expression network analysis: a nanotoxicogenomics study

description: Additional file 5.
DOI: 10.6084/m9.figshare.19194281
title: Additional file 6 of Evaluating the cytotoxicity and pathogenicity of multi-walled carbon nanotube through weighted gene co-expression network analysis: a nanotoxicogenomics study

description: Additional file 6.
DOI: 10.6084/m9.figshare.19194281.v1
title: Additional file 6 of Evaluating the cytotoxicity and pathogenicity of multi-walled carbon nanotube through weighted gene co-expression network analysis: a nanotoxicogenomics study

description: Additional file 6.
DOI: 10.6084/m9.figshare.19194287
title: Additional file 1 of Metal removal capability of two cyanobacterial species in autotrophic and mixotrophic mode of nutrition

description: Additional file 1: Supplementary Fig. S1.
DOI: 10.6084/m9.figshare.19194287.v1
title: Additional file 1 of Metal removal capability of two cyanobacterial species in autotrophic and mixotrophic mode of nutrition

description: Additional file 1: Supplementary Fig. S1.
DOI: 10.6084/m9.figshare.19194290
title: Additional file 2 of Metal removal capability of two cyanobacterial species in autotrophic and mixotrophic mode of nutrition

description: Additional file 2: Supplementary Fig. S2.
DOI: 10.6084/m9.figshare.19194290.v1
title: Additional file 2 of Metal removal capability of two cyanobacterial species in autotrophic and mixotrophic mode of nutrition

description: Additional file 2: Supplementary Fig. S2.
DOI: 10.6084/m9.figshare.19194293
title: Additional file 3 of Metal removal capability of two cyanobacterial species in autotrophic and mixotrophic mode of nutrition

description: Additional file 3: Supplementary Fig. S3.
DOI: 10.6084/m9.figshare.19194293.v1
title: Additional file 3 of Metal removal capability of two cyanobacterial species in autotrophic and mixotrophic mode of nutrition

description: Additional file 3: Supplementary Fig. S3.
DOI: 10.6084/m9.figshare.19194276
title: Additional file 10 of Loss of REST in breast cancer promotes tumor progression through estrogen sensitization, MMP24 and CEMIP overexpression

description: Additional file 10.
DOI: 10.6084/m9.figshare.19194276.v1
title: Additional file 10 of Loss of REST in breast cancer promotes tumor progression through estrogen sensitization, MMP24 and CEMIP overexpression

description: Additional file 10.
DOI: 10.6084/m9.figshare.19194309.v1
title: Additional file 9 of Loss of REST in breast cancer promotes tumor progression through estrogen sensitization, MMP24 and CEMIP overexpression

description: Additional file 9.
DOI: 10.6084/m9.figshare.19194309
title: Additional file 9 of Loss of REST in breast cancer promotes tumor progression through estrogen sensitization, MMP24 and CEMIP overexpression

description: Additional file 9.
DOI: 10.6084/m9.figshare.19194341
title: Additional file 3 of Emergence of distinct syntenic density regimes is associated with early metazoan genomic transitions

description: Additional file 3: Supplementary Dataset 2. GO enrichment tables.
DOI: 10.6084/m9.figshare.19194341.v1
title: Additional file 3 of Emergence of distinct syntenic density regimes is associated with early metazoan genomic transitions

description: Additional file 3: Supplementary Dataset 2. GO enrichment tables.
DOI: 10.6084/m9.figshare.19194344
title: Additional file 4 of Emergence of distinct syntenic density regimes is associated with early metazoan genomic transitions

description: Additional file 4: Supplementary Dataset 3. Syntenic density database.
DOI: 10.6084/m9.figshare.19194344.v1
title: Additional file 4 of Emergence of distinct syntenic density regimes is associated with early metazoan genomic transitions

description: Additional file 4: Supplementary Dataset 3. Syntenic density database.
DOI: 10.6084/m9.figshare.19194347
title: Additional file 5 of Emergence of distinct syntenic density regimes is associated with early metazoan genomic transitions

description: Additional file 5: Supplementary Table 1. Summary of GO terms enriched in MLCA blocks
DOI: 10.6084/m9.figshare.19194347.v1
title: Additional file 5 of Emergence of distinct syntenic density regimes is associated with early metazoan genomic transitions

description: Additional file 5: Supplementary Table 1. Summary of GO terms enriched in MLCA blocks
DOI: 10.6084/m9.figshare.19194353
title: Additional file 6 of Emergence of distinct syntenic density regimes is associated with early metazoan genomic transitions

description: Additional file 6: Supplementary Table 2. Summary of GO terms enriched in PLCA blocks.
DOI: 10.6084/m9.figshare.19194353.v1
title: Additional file 6 of Emergence of distinct syntenic density regimes is associated with early metazoan genomic transitions

description: Additional file 6: Supplementary Table 2. Summary of GO terms enriched in PLCA blocks.
DOI: 10.6084/m9.figshare.19194356
title: Additional file 7 of Emergence of distinct syntenic density regimes is associated with early metazoan genomic transitions

description: Additional file 7: Supplementary Table 3. Summary of GO terms enriched in BLCA blocks.
DOI: 10.6084/m9.figshare.19194356.v1
title: Additional file 7 of Emergence of distinct syntenic density regimes is associated with early metazoan genomic transitions

description: Additional file 7: Supplementary Table 3. Summary of GO terms enriched in BLCA blocks.
DOI: 10.6084/m9.figshare.19194408
title: Additional file 2 of Multi-omics data integration reveals link between epigenetic modifications and gene expression in sugar beet (Beta vulgaris subsp. vulgaris) in response to cold

description: Additional file 2: Supplementary Table S1. Merged annotation and Arabidopsis homologs of all DEGs. Supplementary Table S2. Databases used for annotation of DEGs and assignment of Arabidopsis homologs.
DOI: 10.6084/m9.figshare.19194408.v1
title: Additional file 2 of Multi-omics data integration reveals link between epigenetic modifications and gene expression in sugar beet (Beta vulgaris subsp. vulgaris) in response to cold

description: Additional file 2: Supplementary Table S1. Merged annotation and Arabidopsis homologs of all DEGs. Supplementary Table S2. Databases used for annotation of DEGs and assignment of Arabidopsis homologs.
DOI: 10.6084/m9.figshare.19194422
title: Additional file 1 of Gender-affirming hormone therapy induces specific DNA methylation changes in blood

description: Additional file 1: Table S1. DMPs in transgender women (TW) on feminizing GAHT 6-month or 12-month comparison.
DOI: 10.6084/m9.figshare.19194422.v1
title: Additional file 1 of Gender-affirming hormone therapy induces specific DNA methylation changes in blood

description: Additional file 1: Table S1. DMPs in transgender women (TW) on feminizing GAHT 6-month or 12-month comparison.
DOI: 10.6084/m9.figshare.19194425
title: Additional file 2 of Gender-affirming hormone therapy induces specific DNA methylation changes in blood

description: Additional file 2: Table S2. DMPs in transgender men (TM) on masculinizing GAHT 6-month or 12-month comparison.
DOI: 10.6084/m9.figshare.19194425.v1
title: Additional file 2 of Gender-affirming hormone therapy induces specific DNA methylation changes in blood

description: Additional file 2: Table S2. DMPs in transgender men (TM) on masculinizing GAHT 6-month or 12-month comparison.
DOI: 10.6084/m9.figshare.19194428
title: Additional file 3 of Gender-affirming hormone therapy induces specific DNA methylation changes in blood

description: Additional file 3: Table S3. Gene Ontology terms for genes associated with DMPs in each k-means cluster shown in Figure S4.
DOI: 10.6084/m9.figshare.19194428.v1
title: Additional file 3 of Gender-affirming hormone therapy induces specific DNA methylation changes in blood

description: Additional file 3: Table S3. Gene Ontology terms for genes associated with DMPs in each k-means cluster shown in Figure S4.
DOI: 10.6084/m9.figshare.19194431
title: Additional file 4 of Gender-affirming hormone therapy induces specific DNA methylation changes in blood

description: Additional file 4: Table S4. DMPs in transgender women (TW) on feminizing GAHT using the timecourse model.
DOI: 10.6084/m9.figshare.19194434
title: Additional file 5 of Gender-affirming hormone therapy induces specific DNA methylation changes in blood

description: Additional file 5: Table S5. DMPs in transgender men (TM) on masculinizing GAHT using the timecourse model.
DOI: 10.6084/m9.figshare.19194431.v1
title: Additional file 4 of Gender-affirming hormone therapy induces specific DNA methylation changes in blood

description: Additional file 4: Table S4. DMPs in transgender women (TW) on feminizing GAHT using the timecourse model.
DOI: 10.6084/m9.figshare.19194434.v1
title: Additional file 5 of Gender-affirming hormone therapy induces specific DNA methylation changes in blood

description: Additional file 5: Table S5. DMPs in transgender men (TM) on masculinizing GAHT using the timecourse model.
DOI: 10.6084/m9.figshare.19194437
title: Additional file 6 of Gender-affirming hormone therapy induces specific DNA methylation changes in blood

description: Additional file 6: Table S6. 64 DMPs that overlap between transgender women and transgender men 12-month comparisons.
DOI: 10.6084/m9.figshare.19194437.v1
title: Additional file 6 of Gender-affirming hormone therapy induces specific DNA methylation changes in blood

description: Additional file 6: Table S6. 64 DMPs that overlap between transgender women and transgender men 12-month comparisons.
DOI: 10.6084/m9.figshare.19194440
title: Additional file 7 of Gender-affirming hormone therapy induces specific DNA methylation changes in blood

description: Additional file 7: Table S7. Gene Ontology terms for 12m feminizing or masculinizing GAHT, using genes within 1Mb of a DMP or those with a DMP in their promoter (5kb of a DMP).
DOI: 10.6084/m9.figshare.19194440.v1
title: Additional file 7 of Gender-affirming hormone therapy induces specific DNA methylation changes in blood

description: Additional file 7: Table S7. Gene Ontology terms for 12m feminizing or masculinizing GAHT, using genes within 1Mb of a DMP or those with a DMP in their promoter (5kb of a DMP).
DOI: 10.6084/m9.figshare.19194443
title: Additional file 8 of Gender-affirming hormone therapy induces specific DNA methylation changes in blood

description: Additional file 8: Table S8. Differentially methylated regions (DMRs) in transgender women and transgender men comparisons.
DOI: 10.6084/m9.figshare.19194446
title: Additional file 9 of Gender-affirming hormone therapy induces specific DNA methylation changes in blood

description: Additional file 9: Table S9. Sex-specific DMPs affected by GAHT.
DOI: 10.6084/m9.figshare.19194446.v1
title: Additional file 9 of Gender-affirming hormone therapy induces specific DNA methylation changes in blood

description: Additional file 9: Table S9. Sex-specific DMPs affected by GAHT.
DOI: 10.6084/m9.figshare.19194443.v1
title: Additional file 8 of Gender-affirming hormone therapy induces specific DNA methylation changes in blood

description: Additional file 8: Table S8. Differentially methylated regions (DMRs) in transgender women and transgender men comparisons.
DOI: 10.6084/m9.figshare.19194629
title: Supplementary File 6.fasta from Novel protein from larval sponge cells, Ilborin, is related to energy turnover, calcium binding and is conserved among marine invertebrates

description: Sponges (phylum Porifera) are early-branching animals, whose outwardly simple body plan is underlain by a complex genetic repertoire. The transition from a mobile larva to an attached filter-feeding organism occurs by metamorphosis, a process accompanied by a radical change of the body plan and cell transdifferentiation. The continuity between larval cells and adult tissues is still obscure. In a previous study, we have produced polyclonal antibodies against the major protein of the flagellated cells covering the larva of the sponge <i>Halisarca dujardinii</i>, used them to trace the fate of these cells and shown that the larval flagellated cells transdifferentiate into the choanocytes. In the present work, we identified the sequence of this novel protein, which we named Ilborin. A search in the open databases showed that multiple orthologues of the newly identified protein were present in sponges, cnidarians, flatworms, ctenophores and echinoderms, but none of them has been described yet. Ilborin has two conservative domains: triosephosphate isomerase-barrel, which has enzymatic activity against macroergic compounds, and canonical EF-hand, which binds calcium. mRNA of Ilborin is expressed in the larval flagellated cells. We suggest that the new protein is involved in the calcium-mediated regulation of energy metabolism, whose activation precedes metamorphosis.
DOI: 10.6084/m9.figshare.19194629.v1
title: Supplementary File 6.fasta from Novel protein from larval sponge cells, Ilborin, is related to energy turnover, calcium binding and is conserved among marine invertebrates

description: Sponges (phylum Porifera) are early-branching animals, whose outwardly simple body plan is underlain by a complex genetic repertoire. The transition from a mobile larva to an attached filter-feeding organism occurs by metamorphosis, a process accompanied by a radical change of the body plan and cell transdifferentiation. The continuity between larval cells and adult tissues is still obscure. In a previous study, we have produced polyclonal antibodies against the major protein of the flagellated cells covering the larva of the sponge <i>Halisarca dujardinii</i>, used them to trace the fate of these cells and shown that the larval flagellated cells transdifferentiate into the choanocytes. In the present work, we identified the sequence of this novel protein, which we named Ilborin. A search in the open databases showed that multiple orthologues of the newly identified protein were present in sponges, cnidarians, flatworms, ctenophores and echinoderms, but none of them has been described yet. Ilborin has two conservative domains: triosephosphate isomerase-barrel, which has enzymatic activity against macroergic compounds, and canonical EF-hand, which binds calcium. mRNA of Ilborin is expressed in the larval flagellated cells. We suggest that the new protein is involved in the calcium-mediated regulation of energy metabolism, whose activation precedes metamorphosis.