cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.5281/zenodo.17449554
title: CDK9 Governs Splicing Fidelity as an Active Immune Checkpoint in cGAS-MITA/STING-Silenced Tumours

description: While global splicing dysregulation has been associated with tumour immunogenicity, it remains unclear whether cancer cells actively maintain splicing fidelity to evade immune surveillance. Here, we show that the kinase CDK9 functions as an innate immune checkpoint by enforcing RNA splicing fidelity, particularly in cancers with silenced cGAS-MITA/STING signaling. Through phosphorylation of specific splicing factors, designated splicing entropy-regulating core factors (SERCFs) such as SRSF2 at Ser212, CDK9 suppresses splicing entropy. Disruption of this regulatory axis not only leads to the accumulation of immunogenic double-stranded RNAs (dsRNAs) that activate RLR–VISA/MAVS-dependent antiviral pathways but also generates public neoantigens (e.g., NeoARAB18), which are experimentally validated as potent activators of human T cells. Consistently, clinical analyses and in vivo experiments demonstrate that CDK9 inhibition reprograms the tumour microenvironment (TME) and enhances responses to immune checkpoint blockade (ICB) therapy in ER+ breast cancer. Furthermore, pan-cancer analysis extends this mechanism to cGAS-MITA/STING-silenced, immunologically cold tumours, revealing that elevated CDK9 expression and suppressed VISA/MAVS signaling jointly constitute a dual mechanism for immune evasion. Our findings go beyond the observation that splicing errors can trigger immune responses by demonstrating how a pharmacologically targetable kinase actively maintains splicing precision as an intrinsic immune checkpoint, thereby protecting the epitranscriptome from self-recognition.
DOI: 10.3535/1cc-nk7-rf0
title: Cyclodontina H. Beck, 1837

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/ymm-l4f-77m
title: Duplicaria dussumierii (Kiener, 1837)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/da3-ytq-x12
title: Cyclophorus picturatus (L. Pfeiffer, 1854)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/9zy-3vg-pqy
title: Truncatella guerinii A. Villa & J. B. Villa, 1841

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/pw5-znt-pd2
title: Diloma nigerrimum (Gmelin, 1791)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/f0x-ed1-n8k
title: Rhagada convicta (J. C. Cox, 1870)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/nc2-727-q3r
title: Cerithium dialeucum R. A. Philippi, 1849

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/3rt-a6l-9ky
title: Daphniola hadei (E. Gittenberger, 1982)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/clj-t0t-w8p
title: Epiphragmophora trigrammephora (A. d'Orbigny, 1835)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/pkr-b7e-efj
title: Nassarius deshayesii (Hombron & Jacquinot, 1848)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/x0m-0ta-nnb
title: Nassarius nodiferus (Powys, 1835)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/z6n-sx8-p7j
title: Reticunassa crenulicostata (Shuto, 1969)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/4zb-9se-j9l
title: Reticunassa paupera (A. Gould, 1850)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/ha0-s7j-b04
title: Tritia vaucheri (Pallary, 1906)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/2t1-3rj-14b
title: Nassarius canaliculatus (Lamarck, 1822)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/d9l-n7b-92x
title: Nassarius jacksonianus (Quoy & Gaimard, 1833)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/vy6-dqn-zl5
title: Vertigo moulinsiana (Dupuy, 1849)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/52k-jn3-0yk
title: Nassarius graphiterus (Hombron & Jacquinot, 1848)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/dhm-ksm-dc6
title: Nassarius nodicinctus (A. Adams, 1852)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/alh-jyn-94h
title: Nassarius albescens (Dunker, 1846)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/j1x-e2f-w6y
title: Lindholmiola lens (A. Férussac, 1832)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.15468/dl.bdgkgx
title: Occurrence Download

description: A dataset containing 1 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is Armenia",
 "TaxonKey is Galerina marginata"
 ]
}

 The dataset includes 1 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0031669-260208012135463/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.3535/cd9-1lb-fmr
title: Nassarius coronatus (Bruguière, 1789)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/wc9-n8z-ndm
title: Nassarius conoidalis (Deshayes, 1833)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/8am-y2g-yyf
title: Bullia J. E. Gray, 1833

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/vmx-gph-lnb
title: Pseudopeas Putzeys, 1899

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/vj1-31s-b50
title: Pseudopeas Putzeys, 1899

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/w31-6gf-w8v
title: Dorsanum J. E. Gray, 1847

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/kms-c75-5l6
title: Nassarius horridus (Dunker, 1847)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/veb-v5y-0kd
title: Nassarius multivocus H. H. Kool, 2008

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/dym-h0a-5ea
title: Nassarius iodes (Dall, 1917)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/tpx-rzm-t48
title: Tritia incrassata (Strøm, 1768)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/91f-l29-f39
title: Nassarius pullus (Linnaeus, 1758)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/nx5-hdb-cs3
title: Nassarius marratii (E. A. Smith, 1876)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/sky-jqj-82b
title: Tritia corrugata (Brocchi, 1814)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/pjn-5ck-yrm
title: Nassarius jacksonianus (Quoy & Gaimard, 1833)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/q1h-gxe-bme
title: Nassarius crenoliratus (A. Adams, 1852)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/019-qz2-edd
title: Nassarius obvelatus (Deshayes, 1833)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/xtd-hw3-83f
title: Bullia mauritiana J. E. Gray, 1839

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/f85-vs3-w9a
title: Nassarius obvelatus (Deshayes, 1833)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/xtk-s1s-pz2
title: Nassarius deshayesianus (Issel, 1865)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/b9l-jly-ld3
title: Nassarius stolatus (Gmelin, 1791)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/d8z-jxk-mwg
title: Nassarius granosocostatus (Schepman, 1911)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/5rb-vyk-x7r
title: Nassarius Duméril, 1805

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/ec1-h7h-nrm
title: Vitrea subrimata (Reinhardt, 1871)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/3xf-aml-pxs
title: Striarca lactea (Linnaeus, 1758)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/h4g-gcx-lsn
title: Nassarius succinctus (A. Adams, 1852)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/kc3-8ne-rpn
title: Lindholmiola lens (A. Férussac, 1832)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/qj2-kw4-2dj
title: Abra tenuis (Montagu, 1803)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/kjt-y08-nja
title: Nassarius arcadioi Rolán & Hernández, 2005

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.15468/dl.gh8mp8
title: Occurrence Download

description: A dataset containing 35766 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Doryteuthis",
 "HasCoordinate is true",
 "HasGeospatialIssue is false"
 ]
}

 The dataset includes 35766 records from 81 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0031668-260208012135463/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.3535/8ne-031-377
title: Nassarius fissilabris (A. Adams, 1852)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/ljc-nr2-ptf
title: Reticunassa paupera (A. Gould, 1850)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/1vc-fvy-e4q
title: Nassarius signatus (Dunker, 1847)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/ks5-bam-c2e
title: Phrontis versicolor (C. B. Adams, 1852)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.5281/zenodo.18710796
title: embedding_datasets.pkl for Path Signatures Author Anomaly Detection

description: Precomputed embedding datasets (dataset0-3) for Path Signatures for Author Anomaly Detection in NLP. Contains RoBERTa stream embeddings, UMAP/Random Projection projections, and path signatures for Project Gutenberg corpus. Used to skip compute_embeddings and project_embeddings when running nlp_demo.ipynb. See https://github.com/KarenShark/Path-Signature_Anomaly-Detection
DOI: 10.5281/zenodo.18710797
title: embedding_datasets.pkl for Path Signatures Author Anomaly Detection

description: Precomputed embedding datasets (dataset0-3) for Path Signatures for Author Anomaly Detection in NLP. Contains RoBERTa stream embeddings, UMAP/Random Projection projections, and path signatures for Project Gutenberg corpus. Used to skip compute_embeddings and project_embeddings when running nlp_demo.ipynb. See https://github.com/KarenShark/Path-Signature_Anomaly-Detection
DOI: 10.3535/1nz-sbt-rts
title: Nassarius fenistratus (Marrat, 1877)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/h4j-5sc-a30
title: Nassarius coriolis H. H. Kool, 2009

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/7e5-tvm-48p
title: Nassarius sufflatus (A. Gould, 1860)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/ppn-crj-dxm
title: Nassarius haldemani (Dunker, 1847)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/tj0-6ha-bvq
title: Reticunassa silvardi (H. H. Kool & H. Dekker, 2006)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/wc7-m8j-lcn
title: Nassarius celebensis (Schepman, 1907)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/yr7-haz-fab
title: Nassarius scalaris (A. Adams, 1852)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/8ja-drf-q5q
title: Balea heydeni Maltzan, 1881

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/xfs-nqc-gjp
title: Nassarius cinctellus (A. Gould, 1850)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/3z9-4ex-pmb
title: Nassarius festivus (Powys, 1835)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/gpr-f7s-dnx
title: Eoacmaea semirubida (Dall, 1914)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/65h-9qp-9be
title: Tritia reticulata (Linnaeus, 1758)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/m9b-m3d-2fn
title: Venus casina Linnaeus, 1758

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/v78-s31-ab6
title: Nassarius punctatus (A. Adams, 1852)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/evw-grc-lem
title: Nassarius fenwicki Kilburn, 1972

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/qf8-elt-pwk
title: Nassarius Duméril, 1805

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.48323/6jy92-gp532
title: Dataset for Ralser et al. 2024: When water turns to ice: Control of ice volume and freezing dynamics as important aspect of cold acclimation. Environmental and Experimental Botany
DOI: 10.48323/a2yeb-c6x85
title: Dataset for Ralser et al. 2024: When water turns to ice: Control of ice volume and freezing dynamics as important aspect of cold acclimation. Environmental and Experimental Botany
DOI: 10.3535/1b8-bgf-e95
title: Tritia elongata (Bucquoy, Dautzenberg & Dollfus, 1882)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/drf-0dn-tmh
title: Lindholmiola corcyrensis (Rossmässler, 1838)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/38t-6zj-8ng
title: Reticunassa tringa (Souverbie, 1864)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/9ap-1t5-ysf
title: Nassarius rainbowae Gili, 2015

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/w9k-scm-11y
title: Nassarius crassiusculus (Nyst, 1845)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/6xw-422-fea
title: Nassarius filmerae (G. B. Sowerby III, 1900)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/km1-lp9-q4f
title: Helicodonta obvoluta obvoluta (O. F. Müller, 1774)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/5v5-fj2-x0v
title: Nassarius argenteus (Marrat, 1877)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/x84-b2v-tt4
title: Nassarius Duméril, 1805

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/g2b-sk3-m1z
title: Nassarius Duméril, 1805

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/ktb-3hq-hff
title: Cyllene lamarcki Cernohorsky, 1975

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/81d-71p-ls1
title: Nassarius Duméril, 1805

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/ljg-ca2-1dx
title: Nassarius elegantissimus Shuto, 1969

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/qxh-aa2-sjp
title: Nassarius graphiterus (Hombron & Jacquinot, 1848)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/xj1-01e-83w
title: Nassarius Duméril, 1805

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/8me-7vx-1fr
title: Demoulia obtusata (Link, 1807)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/w2y-p1p-ds4
title: Nassarius dekkeri H. H. Kool, 2001

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/ng6-cw0-reg
title: Phrontis hotessieriana (A. d'Orbigny, 1842)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.5281/zenodo.18711091
title: Extended Thromboprophylaxis After Hip Fracture Surgery: Real-World Evidence of Direct Oral Anticoagulants Versus Low Molecular Weight Heparin or Unfractionated Heparin

description: Anonymized raw data supporting the analyses presented in the study " “Extended Thromboprophylaxis After Hip Fracture Surgery: Real-World Evidence of Direct Oral Anticoagulants Versus Low Molecular Weight Heparin or Unfractionated Heparin.”
DOI: 10.5281/zenodo.18711092
title: Extended Thromboprophylaxis After Hip Fracture Surgery: Real-World Evidence of Direct Oral Anticoagulants Versus Low Molecular Weight Heparin or Unfractionated Heparin

description: Anonymized raw data supporting the analyses presented in the study " “Extended Thromboprophylaxis After Hip Fracture Surgery: Real-World Evidence of Direct Oral Anticoagulants Versus Low Molecular Weight Heparin or Unfractionated Heparin.”
DOI: 10.15468/dl.kte393
title: Occurrence Download

description: A dataset containing 345 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is China",
 "GadmGid is CHN.28_1",
 "TaxonKey is one of (Blitum, Chenopodium, Rhodiola, Carex, Ephedra, Stipa, Elymus, Polygonum, Rheum, Leontopodium, Comarum, Potentilla, Rosa)",
 "Year 2000-2026"
 ]
}

 The dataset includes 345 records from 13 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0031670-260208012135463/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.57903/uj/lpvz8k
title: Hydration-driven metabolic activity enhances the resilience of Xanthoria parietina (L.) Th. Fr. to nitrate stress

description: This dataset includes an Excel file containing physiological and biochemical parameters of studied lichen samples.
DOI: 10.15468/dl.txs8a9
title: Occurrence Download

description: A dataset containing 13 species occurrences available in GBIF matching the query:
{
 "and" : [
 "GadmGid is CHN.29_1",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 "TaxonKey is Macaca mulatta"
 ]
}

 The dataset includes 13 records from 2 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0031676-260208012135463/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.48505/nims.2478
title: XAFS spectrum of Platinum(II) bromide, anhydrous

description: This dataset consists of X-ray absorption fine structure (XAFS) spectra at Pt L1-edge of Platinum(II) bromide, anhydrous measured at SPring-8 BL14B2, and is a part of XAFS database (MDR XAFS DB, https://doi.org/10.48505/nims.1447) as a collection of MDR
DOI: 10.48505/nims.1698
title: XAFS spectrum of Cerium(IV) hydroxide

description: This dataset consists of X-ray absorption fine structure (XAFS) spectra at Ce L3-edge of Cerium(IV) hydroxide measured at SPring-8 BL14B2, and is a part of XAFS database (MDR XAFS DB, https://doi.org/10.48505/nims.1447) as a collection of MDR
DOI: 10.48505/nims.2956
title: XAFS spectrum of Nickel silver

description: This dataset consists of X-ray absorption fine structure (XAFS) spectra at Ni K-edge of Nickel silver measured at SPring-8 BL14B2, and is a part of XAFS database (MDR XAFS DB, https://doi.org/10.48505/nims.1447) as a collection of MDR
DOI: 10.48505/nims.1627
title: XAFS spectrum of Barium chromate

description: This dataset consists of X-ray absorption fine structure (XAFS) spectra at Ba L3-edge of Barium chromate measured at SPring-8 BL14B2, and is a part of XAFS database (MDR XAFS DB, https://doi.org/10.48505/nims.1447) as a collection of MDR