DOI: 10.6084/m9.figshare.29882297.v1
title: <b>epDevAtlas v1</b>

description: The Early Postnatal Mouse Brain Developmental Atlas, Version 1.0 (epDevAtlas v1) is a suite of open access resources including 3D atlases of the early postnatally developing mouse brain and mapped cell type density growth charts, which can be used as standalone resources or to implement data integration. Deposited in figshare is a collection of data used for the epDevAtlas v1 web platform, which can be utilized to analyze and visualize the spatiotemporal growth of GABAergic, microglial, and cortical layer-specific cell type densities in 3D. Morphologically averaged symmetric template brains serve as the basis reference space and coordinate system with an isotropic resolution of 20 µm (XYZ in coronal plane). Average transformations were conducted at 20 µm voxel resolution by interpolating high resolution serial two photon tomography images from primarily Vip-IRES-Cre;Ai14 mice at postnatal (P) ages P4, P6, P8, P10, P12, and P14. For all ages, anatomical labels from the P56 Allen Mouse Brain Common Coordinate Framework (Allen CCFv3) were iteratively down registered to each early postnatal time point in a non-linear manner, aided by manual parcellations of landmarks in 3D, consistent with the Allen Mouse Reference Atlas Ontology. All 3D-counted cell types were registered to age-matched epDevAtlas templates and annotations.<br><b>Ages included</b>:<br>Postnatal day (P) 4, 6, 8, 10, 12, 14, 56<br>See <b>README.txt</b> forData ElementsAbbreviationsContents DescriptionLicenseConditions for UseCitation InformationSupportRelated LinksRelease Notes.<b>Content Organization</b>Data folders are labeled by ageData files within each 'Age' folder are include age-matched Allen CCFv3 anatomical labels, reference brain template, and registered counted cell type data.Additional information in ReadMe file<b>Conditions for Use</b>The epDevAtlas is a Brain Initiative Cell Census Network (BICCN) resource.BICCN data, tools, and resources, including the DevCCF are generally released under the Creative Commons Attribution 4.0 International Public License (CC BY 4.0, https://creativecommons.org/licenses/by/4.0/legalcode) (“CC BY 4.0 License”). Under the CC BY 4.0 License external data users may freely download, analyze and publish results based on any BICCN open-access data and tools as soon as they are released, provided they give appropriate credit, a link to the license, and indicate if changes were made. The CC BY 4.0 License applies to all open-access datasets generated by individual members of the Network, regardless of type or size.Researchers using unpublished BICCN data are encouraged to contact the data producers to discuss possible coordinated publications; however, this is optional. The Network will continue to publish the results of its own analysis efforts in independent publications.<b>Citation Information</b>Please cite both the epDevAtlas manuscript in Nature Communications and this dataset if using the epDevAtlas in your work.We require that researchers who use BICCN datasets (published or unpublished) in any tools, web applications, presentations, and publications cite and acknowledge the BICCN and BICCN production laboratory(s) for referenced dataset(s).<b>Release Notes</b>epDevAtlas v1 (current release):This update is paired with the Liwang et al (2025) epDevAtlas manuscript in Nature Communications journal