cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.19920726.v1
title: Quality of Handroanthus serratifolius (Vahl) S. O. Grose seeds evaluated by the electrical conductivity test

description: ABSTRACT - The electrical conductivity test (EC) used to evaluate seed vigor is directly related to the integrity of cell membranes, but its use in forest species is still restricted. Thus, the objective of this study is to analyze the efficiency of the EC test to evaluate physiological parameters regarding seed quality and the genetic variability among Handroanthus serratifolius mother trees. Seeds from 15 mother trees were evaluated for germination (G%) and germination speed index (GSI). In the EC test, the seeds were imbibed in two water volumes (75 and 100 mL) at 20 and 25 °C, and the electrical conductivity was measured after five imbibition periods (24, 48, 72, 96, and 120 h). The germination test data were submitted to a randomized block design (RBD) analysis of variance and means were compared by the Scott-Knott test. The EC test was conducted as an RBD in a split-split plot scheme, with interaction unfolding by polynomial regression analysis. The mother trees were divided into four groups regarding G% and SGI. The EC test separated the mother trees into a larger number of groups, regardless of temperature, volume, and imbibition period. In conclusion, the EC test consisting of imbibition 25 seeds in 75 mL of deionized water at 20 °C for 48 h is suitable for evaluating the physiological quality of seeds and the variability among mother trees of Handroanthus serratifolius (Vahl) S. O. Grose.
DOI: 10.6084/m9.figshare.19920730
title: Critical Analysis of Prescriptions Medicines for Problematic Crack Use

description: Abstract A descriptive, exploratory and retrospective study that analyzed medical records of the patients under treatment for crack use; prescriptions and medicines interactions were collected, and the sociodemographic profile of these patients. Revisions of narrative literatures were conducted to verify which medicines have the greatest therapeutic potentials and to characterize the profile of the crack users; data from the medical records and the literature were triangulated. The results suggest: medicines prescribed in the treatment of the crack use are limited, medicines used in practice don’t have evidence of efficacy, there are relevant interactions in the prescriptions, and the sociodemographic profile of these users is similar with the literature. Additional studies are desirable to seek effective medicine treatment for crack use.
DOI: 10.6084/m9.figshare.19920730.v1
title: Critical Analysis of Prescriptions Medicines for Problematic Crack Use

description: Abstract A descriptive, exploratory and retrospective study that analyzed medical records of the patients under treatment for crack use; prescriptions and medicines interactions were collected, and the sociodemographic profile of these patients. Revisions of narrative literatures were conducted to verify which medicines have the greatest therapeutic potentials and to characterize the profile of the crack users; data from the medical records and the literature were triangulated. The results suggest: medicines prescribed in the treatment of the crack use are limited, medicines used in practice don’t have evidence of efficacy, there are relevant interactions in the prescriptions, and the sociodemographic profile of these users is similar with the literature. Additional studies are desirable to seek effective medicine treatment for crack use.
DOI: 10.6084/m9.figshare.19920732
title: Effect of 2,4-D sub-dose on the initial development of common bean crop

description: ABSTRACT - The adoption of cultures tolerant to auxin mimics can increase the occurrence of drift of these herbicides, interfering in the development of naturally sensitive cultures, such as beans. The aim of this study was to evaluate the germination and initial development of bean seedlings, using sub-doses of the herbicide 2,4-D. The design of experiment I was completely randomized, with eight treatments and four replications, except for germination, with eight replications. The seeds were sowed in 100 mL of water with concentrations of 0.0; 1.12; 2.14; 4.18; 8.37; 16.75; 33.50 and 67.00 g a.e. L-1 of 2,4-D. Germination, length, seedling fresh and dry mass and electrical conductivity were evaluated. The design of experiment II was completely randomized with five treatments and four replications. The beans were sowed in sand and then sprayed at concentrations of 0.0; 8.37; 16.75; 33.50 and 67.00 g e.a. L-1 of 2,4-D. Seed emergence, injury, fresh and dry shoot mass were evaluated. According to the regression analysis, there was a reduction in germination, regardless of the concentration used, as well as the seedling length. Seeds sown in this solution presented impaired root system and development, tending to mortality. Electrical conductivity increased as herbicide concentrations increased, indicating lower physiological potential of seeds. In experiment II, increasing 2,4-D concentrations reduced emergence and increased injury to bean plants. It is concluded that the sub-doses of the 2,4-D herbicide negatively affect the germination and initial development of bean seedlings.
DOI: 10.6084/m9.figshare.19920732.v1
title: Effect of 2,4-D sub-dose on the initial development of common bean crop

description: ABSTRACT - The adoption of cultures tolerant to auxin mimics can increase the occurrence of drift of these herbicides, interfering in the development of naturally sensitive cultures, such as beans. The aim of this study was to evaluate the germination and initial development of bean seedlings, using sub-doses of the herbicide 2,4-D. The design of experiment I was completely randomized, with eight treatments and four replications, except for germination, with eight replications. The seeds were sowed in 100 mL of water with concentrations of 0.0; 1.12; 2.14; 4.18; 8.37; 16.75; 33.50 and 67.00 g a.e. L-1 of 2,4-D. Germination, length, seedling fresh and dry mass and electrical conductivity were evaluated. The design of experiment II was completely randomized with five treatments and four replications. The beans were sowed in sand and then sprayed at concentrations of 0.0; 8.37; 16.75; 33.50 and 67.00 g e.a. L-1 of 2,4-D. Seed emergence, injury, fresh and dry shoot mass were evaluated. According to the regression analysis, there was a reduction in germination, regardless of the concentration used, as well as the seedling length. Seeds sown in this solution presented impaired root system and development, tending to mortality. Electrical conductivity increased as herbicide concentrations increased, indicating lower physiological potential of seeds. In experiment II, increasing 2,4-D concentrations reduced emergence and increased injury to bean plants. It is concluded that the sub-doses of the 2,4-D herbicide negatively affect the germination and initial development of bean seedlings.
DOI: 10.6084/m9.figshare.19920735
title: Neurological rehabilitation for a patient with chronic Rasmussen encephalitis: a case report

description: ABSTRACT Rasmussen encephalitis is a rare disease consisting of a chronic, slowly progressive inflammatory reaction of brain tissues. The objective of this study was to describe the case of an 18-year-old female patient, studying on the fourth grade of elementary school, and right-handed, who underwent left hemispherectomy in a neurological rehabilitation program. Her seizures began at 10 years of age and were unresponsive to drug treatment, with functional repercussions. She underwent hemispherectomy in March 2019, with 7 years of ongoing disease, and was admitted for the rehabilitation program with a multidisciplinary team in June 2020. The quality-of-life questionnaire (WHOQOL-BREF) was applied as a comparison measure before and after the rehabilitation program, along with measures of participation on the program activities. Despite the patient’s short time in a rehabilitation program, data show the importance of an interdisciplinary intervention through the establishment of specific and contextualized objectives in chronic patients.
DOI: 10.6084/m9.figshare.19920735.v1
title: Neurological rehabilitation for a patient with chronic Rasmussen encephalitis: a case report

description: ABSTRACT Rasmussen encephalitis is a rare disease consisting of a chronic, slowly progressive inflammatory reaction of brain tissues. The objective of this study was to describe the case of an 18-year-old female patient, studying on the fourth grade of elementary school, and right-handed, who underwent left hemispherectomy in a neurological rehabilitation program. Her seizures began at 10 years of age and were unresponsive to drug treatment, with functional repercussions. She underwent hemispherectomy in March 2019, with 7 years of ongoing disease, and was admitted for the rehabilitation program with a multidisciplinary team in June 2020. The quality-of-life questionnaire (WHOQOL-BREF) was applied as a comparison measure before and after the rehabilitation program, along with measures of participation on the program activities. Despite the patient’s short time in a rehabilitation program, data show the importance of an interdisciplinary intervention through the establishment of specific and contextualized objectives in chronic patients.
DOI: 10.6084/m9.figshare.19920556
title: SELECTION OF INFORMATION TECHNOLOGY SUPPLIERS: A STUDY ON EVALUATION PROCEDURES AND SELECTION CRITERIA

description: ABSTRACT In the selection process of suppliers of services, the evaluation of potential candidates constitutes an important task, because when the evaluation is inadequately performed, the results are not good and it can be incurred incompatible costs. Theoretically, a good evaluation can be a warranty that the recruiting will be successful. This research verified if the companies adopt differentiated procedures when they select suppliers of services of Information Technology (IT). It tried to identify the evaluation procedures and the selection criteria used for the choice of companies that supply IT services. The results showed that, in function of peculiarities of IT activities, the selection process of suppliers incorporate specific characteristics, without however, to present the sophistication initially expected.
DOI: 10.6084/m9.figshare.19920556.v1
title: SELECTION OF INFORMATION TECHNOLOGY SUPPLIERS: A STUDY ON EVALUATION PROCEDURES AND SELECTION CRITERIA

description: ABSTRACT In the selection process of suppliers of services, the evaluation of potential candidates constitutes an important task, because when the evaluation is inadequately performed, the results are not good and it can be incurred incompatible costs. Theoretically, a good evaluation can be a warranty that the recruiting will be successful. This research verified if the companies adopt differentiated procedures when they select suppliers of services of Information Technology (IT). It tried to identify the evaluation procedures and the selection criteria used for the choice of companies that supply IT services. The results showed that, in function of peculiarities of IT activities, the selection process of suppliers incorporate specific characteristics, without however, to present the sophistication initially expected.
DOI: 10.6084/m9.figshare.19920738
title: In vitro and in vivo activity of a hypotoxic copper(I) complex against dermotropic Leishmania species

description: ABSTRACT Cutaneous leishmaniasis is a disease caused by protozoa of the genus Leishmania and, currently, the treatment of first choice is meglumine antimoniate. However, due to its limited effectiveness and high toxicity, it is necessary to seek new active principles for leishmaniasis treatment. Metal complexes are gaining importance due to their effectiveness and low toxicity. In this context, the present study aimed to evaluate the in vitro and in vivo antileishmanial activity of the hypotoxic copper(I) complex [HB(pz)3]Cu(PCN). Four dermotropic species of Leishmania were tested with the metal complex and its effectiveness was determined through parasitic viability and infectivity rate, and cytotoxicity was determined using a redox dye (resazurin). For the in vivo tests, hamsters were infected and the lesions treated with a formulated ointment containing the complex, the effectiveness of which was assessed by measuring the diameter of the inoculum/snout location and determining the parasitic load. The results demonstrated moderate toxicity in murine macrophages and human monocytes and better efficacy in Leishmania (V.) braziliensis when compared to the other species tested, with a 50% reduction in the viability of promastigote and amastigote forms (in vitro). General data from daily topical treatment for up to 30 days showed low efficacy for reducing lesions, and no clinical and parasitological cure was observed in the experimental animals. Thus, the [HB(pz)3]Cu(PCN) complex proved to be promising in in vitro studies against L. (V.) braziliensis, and should be further tested in new formulations and new experimental treatment schemes.
DOI: 10.6084/m9.figshare.19920738.v1
title: In vitro and in vivo activity of a hypotoxic copper(I) complex against dermotropic Leishmania species

description: ABSTRACT Cutaneous leishmaniasis is a disease caused by protozoa of the genus Leishmania and, currently, the treatment of first choice is meglumine antimoniate. However, due to its limited effectiveness and high toxicity, it is necessary to seek new active principles for leishmaniasis treatment. Metal complexes are gaining importance due to their effectiveness and low toxicity. In this context, the present study aimed to evaluate the in vitro and in vivo antileishmanial activity of the hypotoxic copper(I) complex [HB(pz)3]Cu(PCN). Four dermotropic species of Leishmania were tested with the metal complex and its effectiveness was determined through parasitic viability and infectivity rate, and cytotoxicity was determined using a redox dye (resazurin). For the in vivo tests, hamsters were infected and the lesions treated with a formulated ointment containing the complex, the effectiveness of which was assessed by measuring the diameter of the inoculum/snout location and determining the parasitic load. The results demonstrated moderate toxicity in murine macrophages and human monocytes and better efficacy in Leishmania (V.) braziliensis when compared to the other species tested, with a 50% reduction in the viability of promastigote and amastigote forms (in vitro). General data from daily topical treatment for up to 30 days showed low efficacy for reducing lesions, and no clinical and parasitological cure was observed in the experimental animals. Thus, the [HB(pz)3]Cu(PCN) complex proved to be promising in in vitro studies against L. (V.) braziliensis, and should be further tested in new formulations and new experimental treatment schemes.
DOI: 10.57770/tkin5b/7ipxxq
title: graphic abs.png

description: :unav
DOI: 10.57770/tkin5b/lkrwgn
title: Full article

description: Published paper
DOI: 10.6084/m9.figshare.19920741
title: Depression and empathy in health professionals who work in the long-term care institutions for older adults

description: ABSTRACT Empathy is an important factor to guarantee the quality of care provided in the long-term care institutions (LTCIs) for older adults, and depression is a factor that affects the health of the professional and, consequently, the care. Thus, it is important that studies are conducted on the relationship of these variables in this context. Objective: The aim of this study is to verify the relationship between empathy and depressive symptoms among health professionals working in the LTCIs. Methods: A cross-sectional study was carried out at LTCIs in the state of São Paulo, Brazil. The final sample was constituted by 101 health professionals (i.e., caregivers and nursing technicians) with direct participation in the care of institutionalized older adults. The instruments were used as follows: the Interpersonal Reactivity Index (IRI) to assess empathy and the Patient Health Questionnaire-9 (PHQ-9) for the diagnosis of depression. For the analyses, the patients were divided into groups with and without depression, according to the score of the PHQ-9. Results: The prevalence of depression among health professionals was 19.8%. Significant statistical differences were found between the groups for the total score of the IRI (p=0.029), for the emotional domain (p=0.023), and for the personal distress (p=0.009). Conclusions: The findings indicate that the presence of depression among health professionals at LTCIs is related to the higher levels of empathy, especially in the emotional domain. Thus, future studies that contribute to understanding how care must be provided with empathy, but without harming the health of the professional, should be carried out.
DOI: 10.6084/m9.figshare.19920741.v1
title: Depression and empathy in health professionals who work in the long-term care institutions for older adults

description: ABSTRACT Empathy is an important factor to guarantee the quality of care provided in the long-term care institutions (LTCIs) for older adults, and depression is a factor that affects the health of the professional and, consequently, the care. Thus, it is important that studies are conducted on the relationship of these variables in this context. Objective: The aim of this study is to verify the relationship between empathy and depressive symptoms among health professionals working in the LTCIs. Methods: A cross-sectional study was carried out at LTCIs in the state of São Paulo, Brazil. The final sample was constituted by 101 health professionals (i.e., caregivers and nursing technicians) with direct participation in the care of institutionalized older adults. The instruments were used as follows: the Interpersonal Reactivity Index (IRI) to assess empathy and the Patient Health Questionnaire-9 (PHQ-9) for the diagnosis of depression. For the analyses, the patients were divided into groups with and without depression, according to the score of the PHQ-9. Results: The prevalence of depression among health professionals was 19.8%. Significant statistical differences were found between the groups for the total score of the IRI (p=0.029), for the emotional domain (p=0.023), and for the personal distress (p=0.009). Conclusions: The findings indicate that the presence of depression among health professionals at LTCIs is related to the higher levels of empathy, especially in the emotional domain. Thus, future studies that contribute to understanding how care must be provided with empathy, but without harming the health of the professional, should be carried out.
DOI: 10.57770/tkin5b/vnqouc
title: MB size distribution.tab

description: Microbubble size distribution and concentration.
DOI: 10.57770/tkin5b/3noeyx
title: Dox LD50.tab

description: LD50 of Dox in TRAMP cells.
DOI: 10.57770/tkin5b
title: Overcoming Hypoxia-Induced Drug Resistance via Promotion of Drug Uptake and Reoxygenation by Acousto–Mechanical Oxygen Delivery

description: Hypoxia-induced drug resistance (HDR) is a critical issue in cancer therapy. The presence of hypoxic tumor cells impedes drug uptake and reduces the cytotoxicity of chemotherapeutic drugs, leading to HDR and increasing the probability of tumor recurrence and metastasis. Microbubbles, which are used as an ultrasound contrast agent and drug/gas carrier, can locally deliver drugs/gas and produce an acousto–mechanical effect to enhance cell permeability under ultrasound sonication. The present study applied oxygen-loaded microbubbles (OMBs) to evaluate the mechanisms of overcoming HDR via promotion of drug uptake and reoxygenation. A hypoxic mouse prostate tumor cell model was established by hypoxic incubation for 4 h. After OMB treatment, the permeability of HDR cells was enhanced by 23 ± 5% and doxorubicin uptake was increased by 11 ± 7%. The 61 ± 14% reoxygenation of HDR cells increased the cytotoxicity of doxorubicin from 18 ± 4% to 58 ± 6%. In combination treatment with OMB and doxorubicin, the relative contributions of uptake promotion and reoxygenation towards overcoming HDR were 11 ± 7% and 28 ± 10%, respectively. Our study demonstrated that reoxygenation of hypoxic conditions is a critical mechanism in the inhibition of HDR and enhancing the outcome of OMB treatment.
DOI: 10.6084/m9.figshare.19920744.v1
title: Experimental dimensions and precision in trials with millet and slender leaf rattlebox

description: ABSTRACT - The objective of this study was to determine the optimal plot size to evaluate fresh matter in millet (Pennisetum glaucum L.) and slender leaf rattlebox (Crotalaria ochroleuca), in scenarios formed by combinations of numbers of treatments, numbers of replicates, and levels of precision. Fifteen uniformity trials with millet and slender leaf rattlebox, in single cropping or intercropping, were carried out. Fresh matter was evaluated in 540 basic experimental units (BEU) of 1 m × 1 m (15 trials × 36 BEU per trial). The soil heterogeneity index of Smith (1938) was estimated. Plot size was determined by the method of Hatheway (1961) in scenarios formed by combinations of i treatments (i = 5, 10, 15 and 20), r replicates (r = 3, 4, 5, 6, 7 and 8), and d precision levels (d = 2%, 4%, 6%, 8%, 10%, 12%, 14%, 16%, 18% and 20%). To evaluate the fresh matter of millet and slender leaf rattlebox, in single or intercropping, in experiments in completely randomized or randomized block designs, with 5 to 20 treatments and with five replicates, plots with 10 m² of usable area are sufficient for differences between treatments of 10% of the overall mean of the experiment to be considered significant at 0.05 probability level.
DOI: 10.6084/m9.figshare.19920744
title: Experimental dimensions and precision in trials with millet and slender leaf rattlebox

description: ABSTRACT - The objective of this study was to determine the optimal plot size to evaluate fresh matter in millet (Pennisetum glaucum L.) and slender leaf rattlebox (Crotalaria ochroleuca), in scenarios formed by combinations of numbers of treatments, numbers of replicates, and levels of precision. Fifteen uniformity trials with millet and slender leaf rattlebox, in single cropping or intercropping, were carried out. Fresh matter was evaluated in 540 basic experimental units (BEU) of 1 m × 1 m (15 trials × 36 BEU per trial). The soil heterogeneity index of Smith (1938) was estimated. Plot size was determined by the method of Hatheway (1961) in scenarios formed by combinations of i treatments (i = 5, 10, 15 and 20), r replicates (r = 3, 4, 5, 6, 7 and 8), and d precision levels (d = 2%, 4%, 6%, 8%, 10%, 12%, 14%, 16%, 18% and 20%). To evaluate the fresh matter of millet and slender leaf rattlebox, in single or intercropping, in experiments in completely randomized or randomized block designs, with 5 to 20 treatments and with five replicates, plots with 10 m² of usable area are sufficient for differences between treatments of 10% of the overall mean of the experiment to be considered significant at 0.05 probability level.