cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.14457/cu.the.2011.184
title: Antinociceptive and anti-inflammatory effects of five root extracts of five root extracts of Ban-Cha-Moon-Yai remedy

description: Ben-Cha-Moon-Yai remedy is an antipyretic and anti-inflammatory drug in Thai traditional medicine which includes roots of Ma-tum, Phe-ka, Lam-yai, Chare-tare and Khad-lin. We initially determined the antinociceptive property of orally administered the root extracts of Ben-Cha-Moon-Yai remedy (BMY), Aegle marmelos (AM), Oroxylum indicum (OI), Dimocarpus longan (DL), Dolichandrone serrulata (DS) and Walsura trichostemon (WT) in the mouse hot-plate test. Hot-plate latencies were determined in male ICR mice prior to the intraperitoneal administration of normal saline solution, morphine (MO; 10 mg/kg) or oral administration of 2% Tween 80, various doses of BMY (125, 250 and 500 mg/kg), AM, OI, DL, DS and WT (25, 50, 100, 200 and 400 mg/kg. All doses of BMY, AM (400 mg/kg), DS (200 and 400 mg/kg) and WT (100-400 mg/kg) produced significant analgesic responses that were naloxone-sensitive suggesting opioid-mediated mechanism. In the formalin-induced nociception test, 2.5% formalin (20 µl) was injected into the plantar surface of the left hind paw of each mouse after intraperitoneal administration of NSS and MO or oral administration of 2% Tween 80, indomethacin (IND; 10 mg/kg), various doses of BMY, AM, OI, DL, DS and WT. BMY (250 mg/kg), AM, DS and WT (400 mg/kg) significantly decreased time spent on paw licking during the early phase, while BMY at all doses tested, AM (400 mg/kg), OI (100-400 mg/kg), DL, DS and WT (200-400 mg/kg) significantly decreased time spent on paw licking during the late phase. In the acetic acid-induced writhing response in mice, animals were induced with intraperitoneal injection of 0.6% acetic acid (10 ml/kg) after oral administration of 2% Tween 80, IND, various doses of BMY, AM, OI, DL, DS and WT. All doses of BMY, AM, DS and WT (200 and 400 mg/kg), OI and DL (100-400 mg/kg) significantly decreased the number of writhes compared to vehicle controls. In rota-rod test, the highest doses of BMY, AM, OI, DL, DS and WT did not produce any motor dysfunction in mice after oral administration. Studies then determined the anti-inflammatory property of orally administered BMY, AM, OI, DL, DS and WT using carrageenan-induced paw edema model in mice. All doses of BMY, AM (400 mg/kg), OI, DL and DS (200 and 400 mg/kg) and WT (25-400 mg/kg) significantly reduced mouse paw edema during the second phase of edema suggesting inhibition of prostaglandins (PGs). In prostaglandin E2–induced mouse paw edema test, the highest dose of AM, OI, DL, DS and WT significantly reduced paw edema during 0.5-1.5 hr after PGE2 administration. Altogether, these results support the antinociceptive effects through both central and peripheral mechanisms of BMY, AM, DS and WT. The analgesic mechanism of action seems to be partly related to opioid receptors. The mechanism of anti-inflammatory effect may be due to the interference of all five root extracts on the liberation of PGs or inhibition of PGE2 effects.
DOI: 10.14457/cu.the.2011.185
title: Functionalized multi-walled carbon nanotube-DNA complex for gene delivery

description: The functionalized multiwalled carbonnanotube-chitosan-plasmid DNA (M/C/D) nanoparticles were prepared by using electrostatic interaction. Multiwalled carbonnanotube(MWCNTs) were functionalized by treating with concentrated sulfuric acid and concentrated nitric acid to improve solubilization and to obtain anionic particles. The percentage of product yield was related to the time that the pristine MWCNTs were contacted to oxidizing agent. The average particle size of functionalized MWCNTs (f-MWCNTs) was 68 to 84.63 nm and zeta potential was -22.44 to -9.58 mV. Chitosan nanoparticles were harmonized with f-MWCNTs for pDNA binding. The electrostatic interactions between f-MWCNTs/CS and pDNA were confirmed by increasing the size distribution and decreasing the zeta potential of formulations. pDNA, 3:1 M/C and the ratio of 3:1:1, 1:11:1, 1:13:1, 1:15:1, 1:17:1 M/C/D nanoparticles presented no noticeable morphology modification of HeLa cells in the 5% CO2 humidified incubator at 37ᵒC for 72 hours. Lipofectamine® and Lipofectamine®-pDNA revealed that HeLa cells reform to round cells and resulted in cell death. f-MWCNTs at concentration below 75 µg/ml was nearly 100% cell viability. The transfection efficiency of formulations determined by the GFP-related fluorescence expression after incubated with formulations for 48 hours. 5:3:1 M/C/D formulation was significantly different compared with negative control (pDNA) (P&lt;0.05). High concentration of f-MWCNTs in nanocomposite could improve the transfection efﬁciency even though the transfection efﬁciency of M/C/D formulation was still lower than that of PolyFect® and Lipofectamine.
DOI: 10.14457/cu.the.2011.186
title: Synthesis of curcumin deriva atives as anti-tumor agents

description: Curcumin is a natural phenolic compound with diverse pharmacological activities and shows synergism effect with paclitaxel in killing cancer cells. However, the compound’s low aqueous solubility and instability in physiological conditions have limited its application. Here water dispersible methoxy poly (ethylene oxide)-palmitate-curcumin conjugate (mPEO-CUR-PA) was synthesized by reacting curcumin with palmitic anhydride to give palmitoyl curcumin(CUR-PA), followed by coupling and coupling with methoxypoly (ethylene oxide) acetic acid (mPEO-COOH) obtained via succinylation of methoxypoly(ethylene oxide). The products could automatically self-assemble into water dispersible microspheres which by themselves showed better anti-tumor activity than free curcumin. The endocytosis of the microspheres into cancer cells was witnessed by confocal laser fluorescent microscope. Paclitaxel could be loaded into the obtained microspheres, and the paclitaxel-loaded mPEO-CUR-PA showed the increasing of anti-tumor activity in both the wild type and the paclitaxel-resistant cancer cells when compared to the activity of free paclitaxel.
DOI: 10.14457/cu.the.2011.187
title: Encapsulation of extract from capsicum frutescens in alginate-chitosan particles

description: Alginate-chitosan microparticles were prepared using complex coacervation technique. These microparticles were formed with different ratio of alginate and chitosan. From the SEM images, microparticles using a chitosan:alginate (CS:ALG) mass ratio of 1:1 showed the best morphology which was spherical and smooth-surface with the average size of 560 ± 38.9 µm. Moreover, particles cross-linked with sodium tripolyphosphate (TPP) had the smaller sizes than those without TPP. The swelling degree of alginate-chitosan microparticles in simulated gastric fluid (SGF, pH 1.2) (about 50%) was lower than that (about 400%) in simulated intestinal fluid (SIF, pH 7.4). Chili oleoresin-loaded alginate-chitosan microparticles were prepared with the CS:ALG mass ratio of 1:1 and using TPP as a cross-linked agent. The highest encapsulation efficiency (73.90%) and loading capacity (10.44%) were obtained from the chitosan/alginate/chili oleoresin mass ratio of 1/1/0.5. The release profile of entrapped chili oleoresin in SGF and SIF was constructed by determining the amount of release capsaicin. At the initial three hours in SGF, capsaicin was slowly release from the microparticles with the release level of 32%. When microparticles were transferred from SGF into SIF medium, capsaicin releasing level increased to be 78% within 4 hours and complete release was not attained in 8 hours. Therefore, the encapsulation can be protected the carotenoids content in chili oleoresin from light, masking pungent taste and reduce irritation to the stomach. Chili extract-loaded alginate-chitosan microparticles can be used as supplementary food.
DOI: 10.14457/cu.the.2011.188
title: Quantification of constuction waste using digital images

description: Construction industry produces not only buildings/ infrastructures but also construction waste. In addition, construction waste contributes to the environment disruption. However, there is less attention to proper waste management at the construction sites. The quantity of waste is known from the number of trucks carrying waste from the site to landfill. On the other hand, an environmentalist requires the information of construction waste to manage the environmental impact. There is no easy-to-use tool or method to quantify the waste production at daily or monthly, basis and the waste production at various places in the multi-storey building construction. This research proposes an alternative method for waste quantification in terms of volume and weight based on digital images. The quantification system consists of three modules; image acquisition, data transfer and image analysis. To obtain the objective, the research was done by pilot research, system design and development, prototype testing, implementation and validation at the construction site. The quantification system offered two approaches based on the simple image and the modified image. The validation of quantification system was compared with the truck capacity and the weight measurement at a weighbridge. The analysis using the 95% limit of agreement showed the level of confidence was about 60 % for volume (in cubic meter) and 70% for weight (in kilogram). The system provides an ease to use for quantifying construction waste at construction site.
DOI: 10.14457/cu.the.2011.90
title: Higher education promotion for knowledge-based economy : a comparative study of brain Korea 21 and Thailand’s National Research Universities

description: The purpose of this research was to study Korea’s direction of education development through nurturing research in higher education institutions and compare Brain Korea 21 Project, which one of the major higher education development strategies to lead Korea toward knowledge-based economy, with Thailand’s National Research Universities Project to improve the policies for the development of Thailand’s higher education institutions. The researches employed documentary research and interviewed the informants of education in South Korea and Thailand. The results showed that Brain Korea 21 Project is an example of Korea’s government strategies to nurture research universities to meet the demand of high quality human resources by providing stipends and allowances to Master and Doctoral students and researchers, who were selected to participate in the project to stimulate competitiveness. It also greatly improved development of excellence human resourcesand, in turn enhance the capacities of universities, while Thailand’s National Research Universities Project represents an effort to promote World-Class University Research. However, the National Research Universities Project is still in early stage and needs some solutions for delay budget and different administration systems of participated universities. Thus, candidness and consistency are necessary to develop Thailand to be regional education hub and enhance internationally competitiveness.
DOI: 10.14457/cu.the.2011.91
title: Warehouse synergy : a case study in PTT

description: At present, the case study companies operate their warehouses independently and also face with the low utilization of capacities. The objective of this thesis is to find the way to improve benefits in the case study companies. After analyzing through the choices of improvement in warehousing area, the most suitable option for the case study companies is to phase out some of the existing warehouses. Therefore, the criteria and the screening process used for evaluate the warehouses must be specified and so called warehouse phasing out process. The warehouse phasing out has been developed based on the academic knowledge and the case study companies data in order to create the feasible solution. There are five main steps in phasing out process which are listed as follows: policy and constraint screening, performance and cost evaluation, phasing out alternatives development, capacity feasibility evaluation, and final analysis of chosen alternative. After implementing the proposed process, the best alternative has been selected since it gives the best benefits to the case study companies. The operation costs can be reduced around 100 million Baht per year after implementing. This result has already validated from the case study company.
DOI: 10.14457/cu.the.2011.92
title: Transition to adulthood in South Korea : a case study of adolescents of lower class family

description: The objective of this research is to study transition to adulthood of adolescents from National Basic Livelihood Security Program (NBLSP) recipient households, who are considered as lower class by focusing on the three issues: educational attainment, labor force participation and family formation.The influences of family relationship: husband – wife relationship and parents - children relationship, on shaping their transition to adulthood will also be studied. This study applied qualitative research method by the in-depth interview data of “Transition from Adolescence to Adulthood II (청년기에서 성인기로의 이행 과정 연구II)” from National Youth Policy Institute (NYPI, 한국 청소년 정책 연구원), South Korea. This research found that South Korean adolescents of lower class family tried to attend higher education in order to find a good and stable job when they enter labor force. Since economic status of their family is an important obstacle, they are only able to study in junior college (two years). During educational attainmet, they have to study and work at the same time or rely on loan for education related expenses. Due to family’s economic needs, these adolescents were forced to enter labor market quite early by working part – time jobs. However, in the aspect of full – time jobs, timing to attend labor force is extended due to prolonged educational period. As for the issue of family formation, these adolescents consider cohabitation positively. All of them want to get married but suitable age for marriage is delayed until they reached the age 25 – 30s when they have economic readiness. This group of adolescent plan to have more than 2 children when they get married.Besides, this research confirmed that family relationships of the adolescents of lower class family greatly affected the transition to adulthood, regarding family economic situation, social adapability and family formation.
DOI: 10.14457/cu.the.2011.93
title: Association between LINE-1 characteristics and gene expression in cancers using data mining techniques

description: Global hypomethylation has been found on L1 in cancer cells. Moreover, having L1 is significantly associated with down regulation of hosting genes for some cancers. Nonetheless, not all genes that possess L1 are down regulated. To identify L1 characteristics that mediate gene expression in cancers, we performed chi-square test and logistic regression for each variable along with decision tree and classification association rules mining for multivariate data analysis. The results from statistical methods indicated the significant L1 characteristics, especially the number of L1, individually associated with gene expression using at significance level α = 0.05. For data mining, the size of the decision tree was too large to be useful. However, rules mining could generate interesting rules. Each cancer dataset has special characteristic rules. Firstly, the derived rules from bladder and liver cancer dataset support the hypothesis that L1 transcription may control down regulation. Both groups of rules suggest the mechanism to promote L1 transcription but different L1 characteristics, the number of L1 &gt; 2 and conserved SRY Site1, respectively. Secondly, the rules derived from prostate cancer represent L1 retrotranspositional activities (conserved ORF1 and/or ORF2) which include L1 transcription, RNA stability and processing, translation, DNA restriction, reverse transcription and insertion. Finally, conserved TF-nkx-2.5 may control down regulation of head and neck cancer. Moreover, the derived rules from the dataset emulating lung cancer by 5-AZA shows that sense and antisense L1 can probably control the expression of genes by either directions of L1 transcription.
DOI: 10.14457/cu.the.2011.94
title: The organizational communication and job satisfaction of Thai employees in Koren transnational companies in Bangkok

description: The purpose of this study is to examine the organizational communication pattern and the relationship between communication satisfaction and job satisfaction of Thai employees in Korean transnational companies in Bangkok under cross-cultural communication. This study follows the concept of human relationships and human resources since an important key strategy for Korean firms to enter globalization is how to develop and manage their human resources to meet the economic and market realities. The questionnaire has been used to collect data from 400 Thai employees during July-August, 2011 and analyze in term of frequency, percentage, mean, and Pearson’s correlation coefficient through SPSS for Windows computer program. The results show that communication pattern between the Korean supervisor and Thai employees in Korean transnational companies in Bangkok is a “two-way communication.” The received information from the Korean supervisors to Thai employees is not only clear and dependable but also effective and satisfied. Since in two-way communication the employees can give a response or feedback to the supervisors, they can express their opinions and suggestions freely. Therefore when the supervisor opens this opportunity for the employees to communicate more, they will have more communication satisfaction (Charin Nana, 1996). And when the communication is effective, the employees tend to understand their job better thus, they will dedicate to work for achieving the organizational goals. In the other word, job satisfaction leads to more interesting and enthusiastic at work thereby the job performance will be increased if the employees feel satisfy with their job (Chamnong Sompasong, 1975).
DOI: 10.14457/cu.the.2011.95
title: Comparison between electroplating and electroless plating method with inkjet printing for conductive line patterning

description: In this thesis, the conductive lines were fabricated by combination of inkjet printing with electroplating and electroless plating method. The conductive lines of silver nanoparticles ink were written by drop-on-demand piezo electric. Then, heat treatment at 150oC was performed. Electroplating was carried out to form a copper layer on top of the silver pattern previously printed. We investigated the effects of metal content in silver nanoparticles ink, and determined the optimal metal loading with appropriate electrical resistivity and surface roughness to be used as seed layer. Moreover, the effect of voltage and plating time applied in electroplating process, and the effect of plating time applied in electroless plating at pH 7 were also studied. The conductive lines fabricated were characterized by a two-point probe, scanning electron microscope with energy dispersive x-ray microanalyzer, x-ray diffractrometer (XRD) and atomic force microscopy (AFM) to confirm the electrical resistivity, microstructure, crystal structure, shape, surface property, adhesion between metal and substrate and aspect ratio.
DOI: 10.14457/cu.the.2011.96
title: Analysis of geological structures in the Southern Mergui Basin, Andaman Sea

description: The southern part of the Mergui Basin in the Andaman Sea, offshore Thailand, has been investigated for its structures. Ten 2D-reflection seismic profiles together with previous core–log and stratigraphic data have been applied to indicate the formations and their associated structures.Nine formations and their average thickness have been identified from the seismic data including, Ranong (oldest, 1,400 m.), Yala (1,120 m.), Kantang (1,300 m), Tai (500 m), Payang (600 m.), Surin (600 m.), Trang (700 m.), Thalang (200 m). and Takuapa (youngest, 200 m). Prograding clinoforms observed at eastern edges of the basin suggest deposition onto slopes with the sequences thicken towards the south. Occurrences of onlap and downlap structures of the Takua Pa and Thalang formations suggest the bathy marine transgression and regression, respectively. Two major sets of steep-dipping faults have been recognized, the north-south trending Mergui Fault and the northeast – southwest trending Ranong Fault, both are found to offset the seafloor and the Thalang Formation with the vertical slip of over 30 m. and 40 m, in Eastern Mergui Basin and Ranong Trough. Flower structures detected in seismic data suggest the strike slip movement along with the normal component. The Mergui Fault displays steep dips to the west. Inversion along this fault exhibits very steep dipping to the east and is usually found in older sequences, i.e, Ranong Formation. The different slip movements along these two faults suggest a possible change in depocenters and tectonic regimes through Neogene times. These two faults are still active untill present. The evolution of the southern Mergui Basin commenced with the Late Oligocene rifting, followed by thermal subsidence and developing the large and thick sedimentation through time.
DOI: 10.14457/cu.the.2011.97
title: Development of farnesol supplemented diets on spawning and growth of giant freshwater prawn Macrobrachium rosenbergii

description: The giant freshwater prawn Macrobrachium rosenbergii is an economically important cultured species in Thailand. Early maturation of female prawn caused restrict on growth. In this study, female prawn was used to study effect of farnesol on spawning and growth. Farnesol used in a representation of the MF was initially encapsulated with farnesol/ alginate by 1:0.67 ratios. The overall encapsulation efficiency at before and after freeze-dried processes was 82.6±1.21 % and 83.41±0.23 %, respectively. After freeze drying farnesol capsules were extracted and analyzed. The recovered farnesol was 63.8±0.66 %. One hundred and eighty matured female giant freshwater prawn with average body length 10 cm were obtained from a local farm. Fifteen prawn were reared in close re-circulated water system amount 375 L per culture tank and fed 3 times/day at amount of 5% total body weight for 8 weeks. The tested diets were 0, 0.5, 1 and 2 g farnesol per 100 gram diet. The result showed that farnesol 2 g/ 100 gram diet decreased egg weight and percent number of female spawns and shortened the molting duration. Significantly reduced the egg weight from 2.01 ± 0.32 g to 1.07 ± 0.19 g and shortened the molt duration at 15.92 day.