cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.29543639
title: Study of the effectiveness of different pelvic floor muscle training methods for improving urinary incontinence in patients with prostate cancer after radical prostatectomy

description: Introduction<b>:</b> To compare the effects of different pelvic floor muscle training (PFMT) modes on improving iatrogenic stress urinary incontinence (SUI) recovery in prostate cancer (PCa) patients after radical prostatectomy (RP). Methods<b>:</b> PCa patients who underwent RP were prospectively enrolled and randomized into standard PFMT (S-PFMT) group, somatosensory interactive PFMT (SI-PFMT, an enhanced PFMT) group, and standard PFMT combined with magnetic stimulation (S-PFMT+MS) group. SUI status was evaluated through the International Consultation on Incontinence Questionnaire-Urinary Incontinence Short Form (ICIQ-UI SF) scores and 1-hour pad test. Results<b>:</b> 101 subjects were enrolled, including 48 in S-PFMT group, 39 in SI-PFMT group, and 14 in S-PFMT+MS group. All groups showed significant ICIQ-UI SF score improvement at 3 and 6 months post-RP compared with baseline (all <i>p</i> &lt; 0.001). At 6 months post-RP, significant improvement of 1-hour pad test result was observed (<i>p</i> = 0.012). Compared with those in the other two groups, patients in the S-PFMT+MS group exhibited significantly better SUI improvement (<i>p</i> = 0.033 <i>vs</i>. S-PFMT; <i>p</i> = 0.011 <i>vs</i>. SI-PFMT) at 6 months. Bayesian survival analysis revealed the superior efficacy of the S-PFMT+MS intervention over an extended period. Conclusions: PCa patients may benefit from magnetic stimulation in addition to standard PFMT for post-RP SUI recovery. CLINICAL TRIAL REGISTRATION: HKUCTR-3029, https://www.hkuctr.com/
DOI: 10.6084/m9.figshare.29543639.v1
title: Study of the effectiveness of different pelvic floor muscle training methods for improving urinary incontinence in patients with prostate cancer after radical prostatectomy

description: Introduction<b>:</b> To compare the effects of different pelvic floor muscle training (PFMT) modes on improving iatrogenic stress urinary incontinence (SUI) recovery in prostate cancer (PCa) patients after radical prostatectomy (RP). Methods<b>:</b> PCa patients who underwent RP were prospectively enrolled and randomized into standard PFMT (S-PFMT) group, somatosensory interactive PFMT (SI-PFMT, an enhanced PFMT) group, and standard PFMT combined with magnetic stimulation (S-PFMT+MS) group. SUI status was evaluated through the International Consultation on Incontinence Questionnaire-Urinary Incontinence Short Form (ICIQ-UI SF) scores and 1-hour pad test. Results<b>:</b> 101 subjects were enrolled, including 48 in S-PFMT group, 39 in SI-PFMT group, and 14 in S-PFMT+MS group. All groups showed significant ICIQ-UI SF score improvement at 3 and 6 months post-RP compared with baseline (all <i>p</i> &lt; 0.001). At 6 months post-RP, significant improvement of 1-hour pad test result was observed (<i>p</i> = 0.012). Compared with those in the other two groups, patients in the S-PFMT+MS group exhibited significantly better SUI improvement (<i>p</i> = 0.033 <i>vs</i>. S-PFMT; <i>p</i> = 0.011 <i>vs</i>. SI-PFMT) at 6 months. Bayesian survival analysis revealed the superior efficacy of the S-PFMT+MS intervention over an extended period. Conclusions: PCa patients may benefit from magnetic stimulation in addition to standard PFMT for post-RP SUI recovery. CLINICAL TRIAL REGISTRATION: HKUCTR-3029, https://www.hkuctr.com/
DOI: 10.13130/rd_unimi/6g4l2b/uvlmhk
title: Giugno_1904_Pagina_023.jpg

description: Bulletin of 1904/06/06
DOI: 10.13130/rd_unimi/cea2oy/lln1zr
title: Giugno_1888_Pagina_046.jpg

description: Bulletin of 1888/06/12
DOI: 10.13130/rd_unimi/zbysir/vwooro
title: Giugno_1900_Pagina_029.jpg

description: Bulletin of 1900/06/08
DOI: 10.3535/02r-ln1-xgr
title: Exaeretia ciniflonella Zeller, 1846

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/eyv-4ke-aj2
title: Conistra (Conistra) vaccinii (Linnaeus, 1761)

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.13130/rd_unimi/ewftha/65oxp2
title: Giugno_1906_Pagina_018.jpg

description: Bulletin of 1906/06/05
DOI: 10.3535/wa2-3ws-gx5
title: Catoptria falsella [Denis & Schiffermüller], 1775

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.6084/m9.figshare.28595752
title: National prevalence and incidence of benign prostatic hyperplasia/lower urinary tract symptoms and validated risk factors pattern

description: To date, limited research has been conducted within China to elucidate the national prevalence and incidence rates of benign prostatic hyperplasia/lower urinary tract symptoms (BPH/LUTS). Additionally, there is a scarcity of studies that have systematically investigated the reliable risk factor patterns associated with the development of BPH/LUTS among the Chinese population. The study was in both cross-sectional and prospective cohort study design. The participants were derived from the China Health and Retirement Longitudinal Study (CHARLS). National prevalence and incidence of BPH/LUTS, average onset age of BPH/LUTS, medication rate of BPH/LUTS, and validated risk factors pattern of BPH/LUTS in the Chinese population were investigated. The overall prevalence and annual incidence of BPH/LUTS were 11.10% and 2.23%. In China, the male population affected by BPH/LUTS typically presented at an average age of 55–65 years. However, the medication rate was merely more than 30%. After conducting univariate and multivariate logistic regression analysis in both cross-sectional and prospective cohort study designs, we observed that dyslipidemia was the most stable risk factor of BPH/LUTS occurrence in three adjusted models (OR [95% CI]: 2.41 [1.37–4.25]; 2.05 [1.10–3.81] and 2.40 [1.19–4.84], respectively). This is the first study to delineate the prevalence and incidence of BPH/LUTS in Chinese, at the national level. The study reminded us that it was dyslipidemia rather than other chronic diseases or bad habits that posed a detrimental influence on BPH/LUTS occurrence in Chinese. Our data would facilitate the disease’s early screening and medical policy formulation.
DOI: 10.13130/rd_unimi/zbysir/lubqv3
title: Giugno_1900_Pagina_030.jpg

description: Bulletin of 1900/06/08
DOI: 10.3535/h3t-htr-ln0
title: Cybosia mesomella (Linnaeus, 1758)

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.6084/m9.figshare.28936530.v1
title: Central obesity and its association with benign prostatic hyperplasia: insights from a cross-sectional study of NHANES 2001–2008

description: Benign prostatic hyperplasia (BPH) is a common condition that affects elderly men, but its relationship with central obesity in the American population has not been adequately elucidated. In this study, we included a total of 4,625 participants from the National Health and Nutrition Examination Survey (NHANES) database spanning from 2001 to 2008. We calculated indices related to central obesity for each participant and then employed univariate logistic regression, multivariate logistic regression, restricted cubic splines (RCS), and Akaike’s Information Criterion (AIC) analysis. we found that the indices of Weight, Waist Circumference (WC), waist-to-Height Ratio (WHtR), and Body Roundness Index (BRI) were significantly elevated in the BPH group. In terms of dietary intake, we found that the intake of total fat, saturated fatty acids, monounsaturated fatty acids, polyunsaturated fatty acids, and cholesterol was significantly higher in the BPH group, with polyunsaturated fatty acids and cholesterol meeting the criteria for both univariate and multivariate regression analyses. Weight, WC, WHtR, and BRI can effectively improve the prediction of BPH, which may be associated with the high intake of polyunsaturated fatty acids and cholesterol. Appropriately adjusting the types and total amount of fat intake may prevent the occurrence of prostatic hyperplasia.
DOI: 10.6084/m9.figshare.30644537
title: Biological aging matters: a cross-sectional study uncovering the association between phenotypic age acceleration and erectile dysfunction based on 2360 male individuals

description: The current study aimed to explore the potential associations between Phenotypic Age (PhenoAge)/PhenoAge acceleration (PhenoAgeAccel) and erectile dysfunction (ED). We carried out a cross-sectional study based on data from 2360 male participants from the National Health and Nutrition Examination Survey program in the year 2001−2004. ED was evaluated according to a self-administered questionnaire. PhenoAge and PhenoAgeAccel were employed to evaluate the biological aging speed as previously reported. Weighted logistic regression analyses were performed to reveal the association between either PhenoAge or PhenoAgeAccel and ED. We also applied restricted cubic spline (RCS) models to explore the non-linearity in such associations. Sensitivity analyses were performed to detect the robustness of the main finding. Significantly higher PhenoAge and PhenoAgeAccel were observed in participants with ED compared with no ED group (both <i>p</i> &lt; 0.0001). Multivariate logistic analyses exhibited significant associations of both PhenoAge and PhenoAgeAccel, either in continuous or categorical forms, with ED, with comprehensive adjustment. RCS models revealed the non-linear relationship between either PhenoAge or PhenoAgeAccel and ED. Sensitivity analyses showed the associations between PhenoAge/PhenoAgeAccel and ED remained significant. Our results suggested a significantly positive association between either PhenoAge or PhenoAgeAccel and ED. Future researches are needed to verify our findings.
DOI: 10.6084/m9.figshare.30644537.v1
title: Biological aging matters: a cross-sectional study uncovering the association between phenotypic age acceleration and erectile dysfunction based on 2360 male individuals

description: The current study aimed to explore the potential associations between Phenotypic Age (PhenoAge)/PhenoAge acceleration (PhenoAgeAccel) and erectile dysfunction (ED). We carried out a cross-sectional study based on data from 2360 male participants from the National Health and Nutrition Examination Survey program in the year 2001−2004. ED was evaluated according to a self-administered questionnaire. PhenoAge and PhenoAgeAccel were employed to evaluate the biological aging speed as previously reported. Weighted logistic regression analyses were performed to reveal the association between either PhenoAge or PhenoAgeAccel and ED. We also applied restricted cubic spline (RCS) models to explore the non-linearity in such associations. Sensitivity analyses were performed to detect the robustness of the main finding. Significantly higher PhenoAge and PhenoAgeAccel were observed in participants with ED compared with no ED group (both <i>p</i> &lt; 0.0001). Multivariate logistic analyses exhibited significant associations of both PhenoAge and PhenoAgeAccel, either in continuous or categorical forms, with ED, with comprehensive adjustment. RCS models revealed the non-linear relationship between either PhenoAge or PhenoAgeAccel and ED. Sensitivity analyses showed the associations between PhenoAge/PhenoAgeAccel and ED remained significant. Our results suggested a significantly positive association between either PhenoAge or PhenoAgeAccel and ED. Future researches are needed to verify our findings.
DOI: 10.13130/rd_unimi/6g4l2b/sodekh
title: Giugno_1904_Pagina_024.jpg

description: Bulletin of 1904/06/06
DOI: 10.3535/g1x-z4h-hqj
title: Diacrisia sannio (Linnaeus, 1758)

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.6084/m9.figshare.30479983.v1
title: Comparative assessment of oral medications for overactive bladder in older adults: a systematic review and network meta-analysis

description: To systematically compare the efficacy and safety of medications in elderly with overactive bladder. Pubmed, Embase, Web of Science, and the Cochrane Register of Clinical Trials databases were systematically searched from database inception to July 25, 2023, and randomized, controlled, double-blind trials for overactive bladder in the elderly were screened according to the protocol. Data were analyzed using Stata17.0. In terms of reducing Micturitions, the interventions were ranked: trospium chloride (TRO), fesoterodine (FES) 4/8 mg, vibegron (VIB), mirabegron (MIR) 25/50 mg, tolterodine ER (TOL) 4 mg, placebo (PBO), of which only TOL showed no significant difference compared to placebo; Forsafety, the TEAE of TOL 4/8 mg had the highest incidence and was significantly different from others; MIR, VIB, and FES 4mg were well-tolerated regarding dry mouth and constipation; TOL 4 mg, FES 4/8 mg, and VIB showed a statistically increase from placebo for headache and FES 4/8mg and MIR 25 mg showed a statistically increase for dizziness. TRO 60 mg has the best efficacy in reducing micturitions, but increases the incidence of dry mouth and constipation; VIB and MIR are well tolerated in dry mouth and constipation, but may increase the risk of headache or dizziness.
DOI: 10.3535/efm-ygd-j2c
title: Xestia (Pachnobia) speciosa Hübner, 1813

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.6084/m9.figshare.29815077
title: The impact of lymphocyte count on male erectile dysfunction with clinical validations and its potential metabolic mechanisms through mendelian randomization analysis

description: Erectile dysfunction (ED) is on the rise globally, affecting people’s lives. This article uses Mendelian randomization (MR) to analyze the causal relationship between clinical indicators and ED, and explores the potential metabolic mechanisms involved. Two-sample MR analysis was performed to analyze the causal relationships between 1,400 metabolites and clinical data and ED for revealing its potential metabolic mechanisms using GWAS (Genome-wide association studies) data. The stability of MR analysis was assessed using sensitivity analysis. We then used clinical data to confirm the MR analysis results. The research results indicated that elevated lymphocyte count (LC) can lead to ED risks. To confirm that LC and ED are causally related, we gathered clinical data. We further revealed potential metabolic mechanisms and found that LC can not only reduce the metabolite 4-methylcatechol sulfate levels, lowering the metabolite 4-methylcatechol sulfate levels to increase the risk of ED, and can also increase the metabolite X-24801 levels, raising the metabolite X-24801 levels to increase the risk of ED. A rise in LC could raise the risks of ED by negatively regulating the metabolite 4-methylcatechol sulfate levels and positively controlling the metabolite X-24801 levels.HighlightsThis article uses Mendelian randomization analysis to determine the causal relationship between lymphocyte count and erectile dysfunction, and uses sensitivity analysis to determine its stabilityRevealed the potential mechanism by which lymphocyte count increases the risk of erectile dysfunctionCollecting clinical data validated the results of Mendelian randomization analysisAt present, the methods and efficacy of treating erectile dysfunction in clinical practice are limited. This study provides new ideas for clinical diagnosis and treatment of erectile dysfunction. This article uses Mendelian randomization analysis to determine the causal relationship between lymphocyte count and erectile dysfunction, and uses sensitivity analysis to determine its stability Revealed the potential mechanism by which lymphocyte count increases the risk of erectile dysfunction Collecting clinical data validated the results of Mendelian randomization analysis At present, the methods and efficacy of treating erectile dysfunction in clinical practice are limited. This study provides new ideas for clinical diagnosis and treatment of erectile dysfunction.
DOI: 10.3535/xt1-m2s-tej
title: Lycaena Fabricius, 1807

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.6084/m9.figshare.28028757
title: Association of testicular histopathology with sperm retrieval success rates in men with idiopathic non-obstructive azoospermia

description: Infertility is a major public health issue, with male factors alone contributing to 20–30% of cases. Non-obstructive azoospermia (NOA) is the most severe form, and although techniques like microdissection testicular sperm extraction (mTESE) offer hope, it remains challenging due to its uncertain causes. This study investigates the correlation between testicular histopathology and clinical parameters to enhance sperm retrieval (SR) prediction. We reviewed 57 azoospermic men from Hanoi Medical University Hospital, recruited between January 2021 and September 2023. Inclusion criteria were confirmed azoospermia and exclusion of known NOA causes. All underwent mTESE with testicular biopsies classified into four histopathological patterns. The patients’ mean age was 31.75 ± 5.19 years. SR was successful in 19.3% (11/57). Higher follicle-stimulating hormone (FSH) levels were noted in SR-positive men (<i>p</i> = 0.02). Sertoli cell-only syndrome (SCOS) was the most common pattern. While we found a significant difference in SR rate between testicular histopathology, multivariate analysis showed no strong association. However, FSH levels were predictive of histopathology patterns. Idiopathic NOA (iNOA) represents over 60% of azoospermia cases. mTESE remains the gold standard, and FSH levels may help predict testicular histopathology patterns and improving patients prognosis of SR outcomes.
DOI: 10.6084/m9.figshare.28028757.v1
title: Association of testicular histopathology with sperm retrieval success rates in men with idiopathic non-obstructive azoospermia

description: Infertility is a major public health issue, with male factors alone contributing to 20–30% of cases. Non-obstructive azoospermia (NOA) is the most severe form, and although techniques like microdissection testicular sperm extraction (mTESE) offer hope, it remains challenging due to its uncertain causes. This study investigates the correlation between testicular histopathology and clinical parameters to enhance sperm retrieval (SR) prediction. We reviewed 57 azoospermic men from Hanoi Medical University Hospital, recruited between January 2021 and September 2023. Inclusion criteria were confirmed azoospermia and exclusion of known NOA causes. All underwent mTESE with testicular biopsies classified into four histopathological patterns. The patients’ mean age was 31.75 ± 5.19 years. SR was successful in 19.3% (11/57). Higher follicle-stimulating hormone (FSH) levels were noted in SR-positive men (<i>p</i> = 0.02). Sertoli cell-only syndrome (SCOS) was the most common pattern. While we found a significant difference in SR rate between testicular histopathology, multivariate analysis showed no strong association. However, FSH levels were predictive of histopathology patterns. Idiopathic NOA (iNOA) represents over 60% of azoospermia cases. mTESE remains the gold standard, and FSH levels may help predict testicular histopathology patterns and improving patients prognosis of SR outcomes.
DOI: 10.3535/crv-n3g-3d9
title: Amphipoea fucosa Freyer, 1830

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/vf3-3r2-f4h
title: Tholera decimalis Poda, 1761

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.6084/m9.figshare.30688507
title: A large-sample analysis of vitamin B12 deficiency anemia, the red cell distribution width, and prostate cancer: identification of their causal relationships, shared gene signatures, and key biological mechanisms

description: The causal relationship and mechanisms connecting Vitamin B12 (VB12) deficiency anemia, red cell distribution width (RDW), and prostate cancer (PCa) remain unclear due to small, methodologically limited studies. We performed bidirectional two-sample Mendelian randomization (2SMR) using GWAS to test the causal effects of VB12 deficiency anemia and RDW on PCa. VB12-deprivation cell assays assessed <i>γ</i>-H2AX, cell-cycle distribution, and EMT markers. Mechanistic follow-up used SMR with HEIDI, enrichment, and colocalization analyses. Both VB12 deficiency anemia (OR_IVW = 1.054, 95% CI: 1.018–1.090) and higher RDW (OR_IVW = 1.095, 95% CI: 1.040–1.153) showed modest positive associations with PCa risk by 2SMR. Multiple sensitivity analyses supported robustness, bidirectional tests found no evidence of reverse causation, and VB12-deprivation cell assays further corroborated the MR signals. In multivariable MR, the positive RDW-PCa association persisted after conditioning on CRP and ferritin. SMR identified 68 genes shared between VB12 deficiency anemia and PCa. Colocalization highlighted two priority loci: B3GAT1 (PP4 = 0.94) and SIK2 (PP4 = 0.78), suggesting that expression changes at these genes may mediate prostate cancer susceptibility. Genetic liability to VB12 deficiency anemia and higher RDW showed modest, directionally consistent associations with increased PCa risk. This risk may be mediated through B3GAT1 and SIK2.
DOI: 10.6084/m9.figshare.30688507.v1
title: A large-sample analysis of vitamin B12 deficiency anemia, the red cell distribution width, and prostate cancer: identification of their causal relationships, shared gene signatures, and key biological mechanisms

description: The causal relationship and mechanisms connecting Vitamin B12 (VB12) deficiency anemia, red cell distribution width (RDW), and prostate cancer (PCa) remain unclear due to small, methodologically limited studies. We performed bidirectional two-sample Mendelian randomization (2SMR) using GWAS to test the causal effects of VB12 deficiency anemia and RDW on PCa. VB12-deprivation cell assays assessed <i>γ</i>-H2AX, cell-cycle distribution, and EMT markers. Mechanistic follow-up used SMR with HEIDI, enrichment, and colocalization analyses. Both VB12 deficiency anemia (OR_IVW = 1.054, 95% CI: 1.018–1.090) and higher RDW (OR_IVW = 1.095, 95% CI: 1.040–1.153) showed modest positive associations with PCa risk by 2SMR. Multiple sensitivity analyses supported robustness, bidirectional tests found no evidence of reverse causation, and VB12-deprivation cell assays further corroborated the MR signals. In multivariable MR, the positive RDW-PCa association persisted after conditioning on CRP and ferritin. SMR identified 68 genes shared between VB12 deficiency anemia and PCa. Colocalization highlighted two priority loci: B3GAT1 (PP4 = 0.94) and SIK2 (PP4 = 0.78), suggesting that expression changes at these genes may mediate prostate cancer susceptibility. Genetic liability to VB12 deficiency anemia and higher RDW showed modest, directionally consistent associations with increased PCa risk. This risk may be mediated through B3GAT1 and SIK2.
DOI: 10.3535/tyb-l19-jmn
title: Agrochola (Leptologia) Prout, 1901

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/jnb-zj2-401
title: Ochropacha duplaris (Linnaeus, 1761)

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/xvf-3sj-179
title: Charanyca (Rusina) Stephens, 1829

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/91r-fez-4h7
title: Cucullia gnaphalii (Hübner, 1813)

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/ta4-98n-vgl
title: Ochropacha duplaris (Linnaeus, 1761)

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.