cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.14287463
title: Types of financial and non-financial information disclosure about corporate social responsibility

description: Abstract Corporate social responsibility information assumes, in recent decades, a high importance to preparers and users has intensified since 2007, with the US financial crisis, reflected in Portugal since 2008. The growing volume of information presents several forms of dissemination aimed it is to promote actions that have an impact on business performance and reflection on the vision that stakeholders have of the company in the community in which it operates. The purpose of this article is to list different forms of information dissemination of corporate social responsibility and highlight the channels used strategically for this purpose. Cumulatively want to list advantages and disadvantages of the means to contribute to the questioning of the current use of resources for the promotion of socially responsible information. The methodology used was a literature review of recent studies in which it sought a general area of the state of the art. Cumulatively was used a descriptive research in domestic companies listed on the Lisbon values in the 1st half of 2016 in order to record, analyze and relate the facts established in the literature review in the Portuguese context. We conclude that there is a multitude of information disclosed by companies of their social responsibility: written and unwritten, financial and non-financial, and internal and external. The web pages and traditional reports seem to be the most used, although difficulties persist measure the quantitative report over the quality, it requires greater rigor to ensure superior quality in the produced social responsibility information.
DOI: 10.6084/m9.figshare.14287460
title: Organizational resilience and social marketing: an assessment of foundations and affinities

description: Abstract This essay relates the concepts of organizational resilience to those of social marketing, exposing the commonalities between the fields of study and identifying how both associate to each other. Based on the analysis of the literature on both themes, an assessment of the confluences between resilience and the basic attributes of social marketing was made, in order to identify aspects that articulate such domains of knowledge. The proposal presented here indicates that adaptation and change — of behaviors, ways of proceeding, and attitudes, among others — are responsible for linking the study of resilience to the principles of social marketing, both of which are bound by the need to change behaviors and by the required suitability to certain unexpected situations. Regarding social marketing, a focus on the generation of social welfare was observed, while in the case of organizational resilience, companies focused on the inherent need to change to be competitive in the market, taking advantage of opportunities that may arise from a situation of rupture.
DOI: 10.6084/m9.figshare.14287459
title: Resilience at work: a comparative analysis between functionalist and critical theories

description: Abstract Resilience is a term that began to be used in the organizational context in the late 1990s; however, today it is required as a competence or “profile” for particular openings in the job market. At the same time, a line of research emerged with the fundamental role of analyzing labor relations with focus on the individual and his subjective universe, as well as questioning the functionalist ideas that had prevailed for years in organizational contexts. From this idea, this paper has as an objective to interpret the concept of resilience in literature, focusing on the subjective universe of the worker. For this, an investigation was conducted on the internal and external factors and their influences on the way a worker thinks and acts (subjectivity), with a focus on the concept of resilience. The research was qualitative, exploratory and descriptive in regards to its purpose, and bibliographic in regards to its means, with 59 papers, published between 1999 and 2014, analyzed. The results revealed that the concept of resilience from a functionalist perspective continues to dominate the organizational discourse.
DOI: 10.6084/m9.figshare.14287453
title: Analysis of the Brazilian National Innovation System in the energy sector from the perspective of Brazilian public policies

description: Abstract This article analyzes the Brazilian National Innovation System (NIS) from the perspective of the public policies pointed out in the Action Plan on Science, Technology, and Innovation for the energy sector within the period from 2007 to 2011, i.e. it seeks to answer this question: "Has the Brazilian national science, technology, and innovation policy for the energy sector contributed to construct a favorable environment for innovation?" The reference theoretical framework is the theory of NIS. To achieve this goal, the national and sectoral innovation system, the public policies for the sector, the players involved in the system, the actions and investments for qualifying people, and efforts on research and development (R&D) are addressed, highlighting public and private investments. This study has a qualitative nature, with an exploratory and descriptive approach that resorts to secondary data sources, such as websites, journals, scientific papers, and references, emphasizing scientific papers and government data provided by the world wide web. The findings indicated that the NIS is undergoing a consolidation phase, but there is evidence that it, along with strategic actions for the energy sector, has contributed to provide innovation with a favorable environment.
DOI: 10.6084/m9.figshare.14287451
title: Unconscious manifestations in the leader-follower relationship: contributions of psychoanalytic theory to organizational studies

description: Abstract This study aimed to understand the unconscious manifestations that transgress the leader-follower relationship in organizations. These dyads were formed by opposing dependent pairs, namely: transference-counter transference; projection-introjection; idealization-identification - Freud’s constructs and all of them unconscious phenomena. The theoretical framework presents the history of the psychoanalytic approach of organizations: a) the analysis of psychoanalytic studies, from the social field to the organizational field (considering that, according to Freud, the unconscious is social. In this section the reader will find a brief tour of the five so-called Sociological Studies of Freud); b) the core of the theoretical framework is already constituted by a psychoanalytic reading of the phenomena of leadership, and finally; c) the theory about the three main unconscious dyads that act in the leader-follower relationship. As a method, psycho-sociology and Lévy’s clinical interview were used. The results allow psychoanalytic interpretations by identifying the presence of the dyads, in both leaders and followers discourse. The analysis of the results initially planned in the objectives of this study had to be - for many reasons - altered during the research. One of the reasons is that the relation transference-counter transference dyad found during the study was more complex than expected and that could not be ignored in the analysis. As one of the relations most evidenced, the analysis of the transference-counter transference dyad allows a better understanding of the way in which the identification is generated from the dual relationship between projection and introjection.
DOI: 10.6084/m9.figshare.14287448
title: The crisis, the State, and the mistakes of political administration in contemporary capitalism

description: Abstract This paper aims to promote a broad discussion of the crisis in contemporary capitalism. Besides debating, in the theoretical field, interpretations of the crisis, with the purpose of introducing our perspectives, it also seeks to discuss in a more structural way the State's role in this crisis and how central and functional it has been in the political administration of finance capitalism, with strong implications for the ongoing process of what we call social deconstruction of property. Moreover, a part of the analysis is devoted to Brazil, as the country is, in a way, inserted in the production process, and plays a major role in the global arena. In the end, some considerations about our prospects are drawn. If what we are doing does not matter to most people, and there is a need for change, we are also not prepared to propose or provide changes by a revolutionary way - as is proposed by David Harvey; thus, the construction of a project for our future may be the most appropriate solution at the moment.
DOI: 10.6084/m9.figshare.14287445
title: Antagonism, modernism, and inertia: the Brazilian regulatory policy in three acts

description: Abstract Regulatory policy in Brazil has evolved as a result of the political-ideological interchanges between political coalitions that have governed the country over the last two decades. However, this has not been the only element outlining the policy. Since the State reform in the 1990s, regulation has been conceptually attached to a liberalizing rationale of economic policy and it is, from the theoretical viewpoint, highly dependent on modernizing currents in the field of international public management. The main consequence of this consists in poorly structured and, to some extent, incoherent movements regarding this public policy. At different moments, the assimilation of modernizing global trends has lost ground to ideological antagonisms or periods of significant stagnation. Thus, this article aims to prospect the main stages of the recent history of the Brazilian regulatory policy by means of a detailed evaluation of the most relevant aspects behind this public policy. The three acts demarcating distinct phases and the specific problems that have changed the core of the policy for regulatory management will be introduced. The relation between State, market, and society is crucial to understand the creation of this public policy, as well as the assimilation and resilience degrees of regulatory tools adopted by the country. In the end, it is possible to notice that the regulatory policy still remains partial and deficient at the federal level, although clear tendencies are already perceptible, particularly the permeability to resocialization and decentralization elements.
DOI: 10.6084/m9.figshare.14287441
title: Organizational resilience and sustainable innovation: a study on the human resources management model at a Brazilian energy company

description: Abstract:This article aims to relate the concept of sustainable innovative organization to the concept of organizational resilience. To do this, a study was carried out at the human resources department of EBE S.A., a Brazilian energy company. This paper conducts a theoretical review of the concepts of resource-based vision, core competencies, dynamic capabilities, strategic human resources management, learning organization, organizational resilience, sustainable innovative organization, and, finally, it identifies which are the human resources management practices of EBE S.A. that contribute to make the company a Resilient Sustainable Innovative Organization.
DOI: 10.6084/m9.figshare.14287435
title: Utopia as organizational imagination in Guerreiro-Ramos' critical thought

description: This article discusses the main issues of the academic production of Alberto Guerreiro-Ramos as part of Latin American critical thought in administration studies. His basic proposals are analyzed from the perspective of utopianism, which is comprehended as a systematic investigation of alternative principles of organization, which are distinctive of the functionalist form of the enterprise. Seminal concepts, such as sociological reduction, parenthetical man and the theory of social systems delimitation, are explored from an utopian perspective approach; i.e. on the reformulation of social structures and dynamics proposed by Guerreiro-Ramos as alternatives to the market ethos. This paper also explains how the dynamic interaction between organizations and society can imagine alternatives to instrumental conceptions of management, options that pursue emancipation, substantive reason and human fulfillment.
DOI: 10.6084/m9.figshare.14287429
title: A "society of the spectacle" in/of the Brazilian organizational studies: critical notes on an incipient reading

description: This article analyzes the reception of Guy Debord in Administration. For this, it resorts to the author's critical theory in order to explore the ways how researchers in the field have been incorporating the French theorist's thought in their works. With scientific papers in hands and referring to the Western critical tradition inaugurated in the first decades of the 20th century, we introduce the limits and possibilities of these assumptions in Administration, in order to open up research possibilities with such a little-known essayist. We think that critical theory on the society of the spectacle, contrary to what has been done in organizational studies, and the reading by some Latin American intellectuals, is not restricted only to cultural studies. Thus, the way how to adopt Debord and his criticism in Administration is useful as a criticism to Administration just as the whole spectacle is criticized.
DOI: 10.6084/m9.figshare.14287424
title: In situ cellular immune response in non-ulcerated skin lesions due to Leishmania (L.) infantum chagasi infection

description: Abstract Background Skin lesions of patients affected by non-ulcerated cutaneous leishmaniasis (NUCL) caused by L. (L.) infantum chagasi are characterized by lymphohistiocytic inflammatory infiltrate associated with epithelioid granuloma and scarce parasitism. However, the in situ cellular immune response of these patients is unclear. Therefore, the aim of the present study was to characterize the cellular immune response in the skin lesions of patients affected by NUCL. Methods Twenty biopsies were processed by immunohistochemistry using primary antibodies to T lymphocytes (CD4, CD8), NK cells, B lymphocytes, macrophages, nitric oxide synthase and interferon-gamma. Results Immunohistochemistry revealed higher expression of all cellular types and molecules (IFN-γ, iNOS) in the dermis of diseased skin compared to the skin of healthy individuals (p &lt; 0.05). Morphometric analysis performed in the skin lesions sections showed the predominance of CD8+ T lymphocytes in the mononuclear infiltrate, followed by macrophages, mostly iNOS+, a response that could be mediated by IFN-γ. Conclusion Our study improves knowledge of the cellular immune response in non-ulcerated or atypical cutaneous leishmaniasis caused by L. (L.) infantum chagasi in Central America and pointed to the pivotal participation of CD8+ T lymphocytes in the host defense mechanisms against the parasite in patients with NUCL.
DOI: 10.6084/m9.figshare.14287423
title: Hello, kitty: could cat allergy be a form of intoxication?

description: Abstract Background: The relationship between slow loris (Nycticebus spp.) venom (BGE protein) and the major cat allergen (Fel d 1) from domestic cat (Felis catus) is known for about two decades. Along this time, evidence was accumulated regarding convergences between them, including their almost identical mode of action. Methods: Large-scale database mining for Fel d 1 and BGE proteins in Felidae and Nycticebus spp., alignment, phylogeny proposition and molecular modelling, associated with directed literature review were assessed. Results: Fel d 1 sequences for 28 non-domestic felids were identified, along with two additional loris BGE protein sequences. Dimer interfaces are less conserved among sequences, and the chain 1 shows more sequence similarity than chain 2. Post-translational modification similarities are highly probable. Conclusions: Fel d 1 functions beyond allergy are discussed, considering the great conservation of felid orthologs of this protein. Reasons for toxicity being found only in domestic cats are proposed in the context of domestication. The combination of the literature review, genome-derived sequence data, and comparisons with the venomous primate slow loris may point to domestic cats as potentially poisonous mammals.
DOI: 10.6084/m9.figshare.14287421
title: Escherichia coli vacuolating factor, involved in avian cellulitis, induces actin contraction and binds to cytoskeleton proteins in fibroblasts

description: Abstract Background Avian pathogenic Escherichia coli (APEC) isolated from avian cellulitis lesions produces a toxin, named Escherichia coli vacuolating factor (ECVF), that causes cell vacuolization and induces inflammatory response in broiler chicken. Methods We investigated the intracellular activities of ECVF in avian fibroblasts using fluorescence staining, electron microscopy, MTT and LDH measurements. As ECVF act specifically in avian cells, we performed blotting assay followed by mass spectrometry to better understand its initial intracellular protein recognition. Results ECVF induced actin contraction, mitochondrial damage and membrane permeability alterations. Ultrastructural analysis showed intracellular alterations, as nuclear lobulation and the presence of degraded structures inside the vacuoles. Moreover, ECVF induced cell death in fibroblasts. ECVF-biotin associates to at least two proteins only in avian cell lysates: alpha-actinin 4 and vinculin, both involved in cytoskeleton structure. Conclusion These findings demonstrated that ECVF plays an important role in avian cellulitis, markedly in initial steps of infection. Taken together, the results place this toxin as a target for drug and/or vaccine development, instead of the use of large amounts antibiotics.
DOI: 10.6084/m9.figshare.14287420
title: Proteolytic activity of Triatoma infestans saliva associated with PAR-2 activation and vasodilation

description: ABSTRACT Background Triatoma infestans (Hemiptera: Reduviidae) is a hematophagous insect and the main vector of Trypanosoma cruzi (Kinetoplastida: Trypanosomatidae). In the present study, the authors investigated whether a serine protease activity from the saliva of T. infestans has a role in vasomotor modulation, and in the insect-blood feeding by cleaving and activating protease-activated receptors (PARs). Methods T. infestans saliva was chromatographed as previously reported for purification of triapsin, a serine protease. The cleavage activity of triapsin on PAR peptides was investigated based on FRET technology. Mass spectrometry was used to analyze the sites of PAR-2 peptide cleaved by triapsin. NO measurements were performed using the DAN assay (2,3-diaminonapthalene). The vasorelaxant activity of triapsin was measured in vessels with or without functional endothelium pre-contracted with phenylephrine (3 µM). Intravital microscopy was used to assess the effect of triapsin on mouse skin microcirculation. Results Triapsin was able to induce hydrolysis of PAR peptides and showed a higher preference for cleavage of the PAR-2 peptide. Analysis by mass spectrometry confirmed a single cleavage site, which corresponds to the activation site of the PAR-2 receptor. Triapsin induced dose-dependent NO release in cultured human umbilical vein endothelial cells (HUVECs), reaching a maximum effect at 17.58 nM. Triapsin purified by gel-filtration chromatography (10-16 to 10-9 M) was applied cumulatively to mouse mesenteric artery rings and showed a potent endothelium-dependent vasodilator effect (EC30 = 10-12 M). Nitric oxide seems to be partially responsible for this vasodilator effect because L-NAME (L-NG-nitroarginine methyl ester 300 µM), a nitric oxide synthetase inhibitor, did not abrogate the vasodilation activated by triapsin. Anti-PAR-2 antibody completely inhibited vasodilation observed in the presence of triapsin activity. Triapsin activity also induced an increase in the mouse ear venular diameter. Conclusion Data from this study suggest a plausible association between triapsin activity mediated PAR-2 activation and vasodilation caused by T. infestans saliva.
DOI: 10.6084/m9.figshare.14287418
title: Intravitreal injection of peptides PnPa11 and PnPa13, derivatives of Phoneutria nigriventer spider venom, prevents retinal damage

description: Abstract Background: PnPa11 and PnPa13 are synthetic peptides derived from Phoneutria nigriventer spider venom, which display antinociceptive and neuroprotective properties. In this work, we evaluated the safety of intravitreal use and the neuroprotective effect of these peptides. Methods: The cytotoxicity and the antiangiogenic activity of these peptides were evaluated by the sulforhodamine-B method and chicken chorioallantoic membrane (CAM) assay, respectively. The in vivo safety was analyzed in Wistar rats that were intravitreally injected with different doses (0.50; 1.25; 2.50; 3.75 and 5.00 µg/mL) of these peptides (right eye, n = 6). The retinal function was assessed by electroretinography exams (ERG), intraocular pressure (IOP), and histological analyzes. In order to investigate the neuroprotective effect, Wistar rats received intravitreal injections (right eye, n = 6) of peptides at 1.25 µg/mL and then were exposed to blue LED light. In addition, the visual function and the retinal microstructure were verified. Results: Cytotoxicity analyses demonstrated that the peptides did not present any toxicity over ARPE-19 (adult retinal pigmented epithelial) cell line and the antiangiogenic study highlighted that the peptides promoted the reduction of blood vessels. The intravitreal injection did not cause major changes, neither induced any irreversible damage. In the retinal degeneration assay, the ERG records demonstrated that the prior treatment with PnPa11 and PnPa13 protected the retina from damage. Morphological analyses confirmed the ERG findings. Immunoblotting analyses revealed that PnPa11 increased Erk1/2, NR2A, and NR2B retinal expression after the light stress model, but did not cause Akt1 activation, while PnPa13 prevented Erk1/2 and Akt1 dephosphorylation. Conclusions: The intraocular administration of these peptides was well tolerated and presented protective activity against retinal degeneration, suggesting the potential use of these peptides as neuroprotectors in the ophthalmological field.
DOI: 10.6084/m9.figshare.14287414
title: Role of crotoxin in coagulation: novel insights into anticoagulant mechanisms and impairment of inflammation-induced coagulation

description: Abstract Background: Snake venom phospholipases A2 (svPLA2) are biologically active toxins, capable of triggering and modulating a wide range of biological functions. Among the svPLA2s, crotoxin (CTX) has been in the spotlight of bioprospecting research due to its role in modulating immune response and hemostasis. In the present study, novel anticoagulant mechanisms of CTX, and the modulation of inflammation-induced coagulation were investigated. Methods: CTX anticoagulant activity was evaluated using platelet poor plasma (PPP) and whole blood (WB), and also using isolated coagulation factors and complexes. The toxin modulation of procoagulant and pro-inflammatory effects was evaluated using the expression of tissue factor (TF) and cytokines in lipopolysaccharide (LPS)-treated peripheral blood mononuclear cells (PBMC) and in WB. Results: The results showed that CTX impaired clot formation in both PPP and WB, and was responsible for the inhibition of both intrinsic (TF/factor VIIa) and extrinsic (factor IXa/factor VIIIa) tenase complexes, but not for factor Xa and thrombin alone. In addition, the PLA2 mitigated the prothrombinase complex by modulating the coagulation phospholipid role in the complex. In regards to the inflammation-coagulation cross talk, the toxin was capable of reducing the production of the pro-inflammatory cytokines IL-1β, IL-6 and TNF-α, and was followed by decreased levels of TF and procoagulant activity from LPS-treated PBMC either isolated or in WB. Conclusion: The results obtained in the present study recognize the toxin as a novel medicinal candidate to be applied in inflammatory diseases with coagulation disorders.