cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.7270/q2000264
title: BindingDB Entry 50031032: Proposed structural basis of interaction of piperine and related compounds with monoamine oxidases.

description: Small molecule binding data for protein Amine oxidase [flavin-containing] A, Monoamine Oxidase Type B (MAO-B), and Monoamine oxidase, Uniprot P19643, P21396, P21397, Q64133, and Q8BW75
DOI: 10.7270/q2028rr9
title: BindingDB Entry 50032012: 6-Phenyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile as cathepsin S inhibitors.

description: Small molecule binding data for protein Cathepsin K and Cathepsin S, Uniprot O70370, P25774, and P43235
DOI: 10.7270/q21z44fk
title: BindingDB Entry 50030056: TBA

description: Small molecule binding data for protein Isoleucyl-tRNA synthetase, Uniprot P41252
DOI: 10.7270/q23j3cwd
title: BindingDB Entry 50029030: TBA

description: Small molecule binding data for protein Cholecystokinin receptor, Uniprot P30551 and P32239
DOI: 10.7270/q23r0sz6
title: BindingDB Entry 50031031: Optimization of piperidyl-ureas as inhibitors of soluble epoxide hydrolase.

description: Small molecule binding data for protein Cytochrome P450 2C19, Cytochrome P450 2C9, Cytochrome P450 2J2, Epoxide hydratase, and Epoxide hydrolase 2, Uniprot P11712, P33261, P34913, P51589, and P80299
DOI: 10.7270/q23t9hdt
title: BindingDB Entry 50032011: Discovery of novel sphingosine kinase-1 inhibitors. Part 2.

description: Small molecule binding data for protein Cytochrome P450 2C19, Cytochrome P450 2C9, Cytochrome P450 2D6 (2D6), Cytochrome P450 3A, and Sphingosine kinase 1 (SPHK1), Uniprot P08684, P10635, P11712, P33261, and Q9NYA1
DOI: 10.7270/q25q4w4g
title: BindingDB Entry 50030054: TBA

description: Small molecule binding data for protein Metabotropic glutamate receptor 1 and Metabotropic glutamate receptor 5, Uniprot P41594 and Q13255
DOI: 10.7270/q26q1x8v
title: BindingDB Entry 50030044: TBA

description: Small molecule binding data for protein Cannabinoid receptor, Uniprot P20272
DOI: 10.7270/q27944m4
title: BindingDB Entry 50029029: TBA

description: Small molecule binding data for protein Alpha-1 adrenergic receptor, Dopamine D2 receptor, Muscarinic acetylcholine receptor, and Serotonin 1 (5-HT1) receptor, Uniprot P08172, P08173, P08912, P11229, P19327, P20309, P28564, P28565, P30940, P61168, P97714, P97717, and P97718
DOI: 10.7270/q27h1jpx
title: BindingDB Entry 50031030: Sulfonylureido thiazoles as fructose-1,6-bisphosphatase inhibitors for the treatment of type-2 diabetes.

description: Small molecule binding data for protein Fructose-1,6-bisphosphatase 1 and Fructose-1,6-bisphosphatase 1 (FBPase), Uniprot P09467 and Q9QXD6
DOI: 10.7270/q27h1js8
title: BindingDB Entry 50032009: Synthesis and SAR of azolopyrimidines as potent and selective dipeptidyl peptidase-4 (DPP4) inhibitors for type 2 diabetes.

description: Small molecule binding data for protein Cytochrome P450 1A, Cytochrome P450 2C19, Cytochrome P450 2C9, Cytochrome P450 3A, Dipeptidyl peptidase 4 (DPP4), Dipeptidyl peptidase IX, and Dipeptidyl peptidase VIII, Uniprot P05177, P08684, P11712, P27487, P33261, Q6V1X1, and Q86TI2
DOI: 10.7270/q29g5mtb
title: BindingDB Entry 50030053: TBA

description: Small molecule binding data for protein Matrix Metalloproteinase-8 (MMP-8), Matrix metalloproteinase 2/9, and Stromelysin-1, Uniprot P08254, P14780, and P22894
DOI: 10.7270/q2b27v63
title: BindingDB Entry 50029040: TBA

description: Small molecule binding data for protein Cholecystokinin receptor, Uniprot P32238 and P32239
DOI: 10.7270/q2c24wcx
title: BindingDB Entry 50029028: TBA

description: Small molecule binding data for protein NMDA receptor subunit 2C (GluN2C), Uniprot Q00961
DOI: 10.7270/q2c829dn
title: BindingDB Entry 50031029: Discovery of 3,6-dihydro-2H-pyran as a morpholine replacement in 6-aryl-1H-pyrazolo[3,4-d]pyrimidines and 2-arylthieno[3,2-d]pyrimidines: ATP-competitive inhibitors of the mammalian target of rapamycin (mTOR).

description: Small molecule binding data for protein PI3-kinase subunit alpha and Serine/threonine-protein kinase mTOR, Uniprot P42336 and P42345
DOI: 10.7270/q2c829gj
title: BindingDB Entry 50032008: Optimization of privileged structures for selective and potent melanocortin subtype-4 receptor ligands.

description: Small molecule binding data for protein Melanocortin receptor 3 (MC3R), Melanocortin receptor 4, Melanocortin receptor 5 (MC5R), and Melanocyte-stimulating hormone receptor, Uniprot P32245, P33032, P41968, and Q01726
DOI: 10.7270/q2f47p56
title: BindingDB Entry 50030052: TBA

description: Small molecule binding data for protein 5-hydroxytryptamine receptor 1A, Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor, Dopamine receptor, Dopamine receptors; D2 & D4, and Serotonin 2 (5-HT2) receptor, Uniprot P08908, P21917, P28223, P28335, P35462, P41595, and P61169
DOI: 10.7270/q2ft8kzj
title: BindingDB Entry 50029039: TBA

description: Small molecule binding data for protein Protein kinase C alpha type, Uniprot P17252
DOI: 10.7270/q2g160xp
title: BindingDB Entry 50031036: Continued exploration of the triazolopyridine scaffold as a platform for p38 MAP kinase inhibition.

description: Small molecule binding data for protein Mitogen-activated protein kinase 14, Uniprot Q16539
DOI: 10.7270/q2g1611f
title: BindingDB Entry 50032018: Carbamoyloximes as novel non-competitive mGlu5 receptor antagonists.

description: Small molecule binding data for protein Metabotropic glutamate receptor and Metabotropic glutamate receptor 1, Uniprot P31424 and Q13255
DOI: 10.7270/q2h13268
title: BindingDB Entry 50032007: Addressing PXR liabilities of phthalazine-based hedgehog/smoothened antagonists using novel pyridopyridazines.

description: Small molecule binding data for protein G-protein- coupled-like receptor Smoothened (Smo) and Smoothened homolog, Uniprot P56726 and Q99835
DOI: 10.7270/q2jw8dw6
title: BindingDB Entry 50030051: TBA

description: Small molecule binding data for protein RXR alpha/PPAR gamma, Retinoid X receptor gamma/retinoic acid receptor alpha, and Retinoid receptor, Uniprot P10276, P10826, P13631, P19793, P28702, and P48443
DOI: 10.7270/q2ks6rnq
title: BindingDB Entry 50031035: Evaluation of pyrrolin-2-one derivatives synthesized by a new practical method as inhibitors of plasminogen activator inhibitor-1 (PAI-1).

description: Small molecule binding data for protein Plasminogen activator inhibitor-1, Uniprot P05121
DOI: 10.7270/q2ms3swf
title: BindingDB Entry 50031026: Triazole oxytocin antagonists: Identification of an aryloxyazetidine replacement for a biaryl substituent.

description: Small molecule binding data for protein Ghrelin receptor, Kappa-type opioid receptor, Neurokinin 1 receptor, Oxytocin receptor, Vasopressin V1a receptor (V1a), and Vasopressin V2 receptor (V2), Uniprot P25103, P30518, P30559, P37288, P41145, and Q92847
DOI: 10.7270/q2ms3szb
title: BindingDB Entry 50032006: Heteroaryl-linked 5-(1H-benzimidazol-1-yl)-2-thiophenecarboxamides: potent inhibitors of polo-like kinase 1 (PLK1) with improved drug-like properties.

description: Small molecule binding data for protein Cytochrome P450 2C9, Cytochrome P450 3A, Serine/threonine-protein kinase PLK1, and Serine/threonine-protein kinase PLK3, Uniprot P08684, P11712, P53350, and Q9H4B4
DOI: 10.7270/q2pn95nc
title: BindingDB Entry 50030050: TBA

description: Small molecule binding data for protein Renin, Uniprot P00797
DOI: 10.7270/q2qc03dj
title: BindingDB Entry 50029035: TBA

description: Small molecule binding data for protein Myosin light chain kinase, smooth muscle, Protein kinase C (PKC), cAMP-Dependent Protein Kinase (PKA), and cGMP-Dependent Protein Kinase, Uniprot P00516, P00517, P05696, P09216, P11799, P63319, and P68403
DOI: 10.7270/q2qj7hdw
title: BindingDB Entry 50031034: Structure-guided design of alpha-amino acid-derived Pin1 inhibitors.

description: Small molecule binding data for protein Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1, Uniprot Q13526
DOI: 10.7270/q2qj7hgs
title: BindingDB Entry 50032016: The discovery of potent inhibitors of aldosterone synthase that exhibit selectivity over 11-beta-hydroxylase.

description: Small molecule binding data for protein Cytochrome P450 11B2, Cytochrome P450 3A, and Steroid 11-beta-Hydroxylase (CYP11B1), Uniprot P08684, P15538, and P19099
DOI: 10.7270/q2td9xcq
title: BindingDB Entry 50030049: TBA

description: Small molecule binding data for protein MER intracellular domain/EGFR extracellular domain chimera, Uniprot P00533
DOI: 10.7270/q2v40v3f
title: BindingDB Entry 50029033: TBA

description: Small molecule binding data for protein Mammalian target of Rapamycin (mTORC1), Uniprot P62942
DOI: 10.7270/q2v98852
title: BindingDB Entry 50031033: Novel purine and pyrazolo[3,4-d]pyrimidine inhibitors of PI3 kinase-alpha: Hit to lead studies.

description: Small molecule binding data for protein PI3-kinase subunit alpha, PI3-kinase subunit gamma, and Serine/threonine-protein kinase mTOR, Uniprot P42336, P42345, and P48736
DOI: 10.7270/q2v9888d
title: BindingDB Entry 50032013: 3-Cyano-5-fluoro-N-arylbenzamides as negative allosteric modulators of mGlu(5): Identification of easily prepared tool compounds with CNS exposure in rats.

description: Small molecule binding data for protein Metabotropic glutamate receptor, Uniprot P31424
DOI: 10.7270/q2z60p30
title: BindingDB Entry 50030047: TBA

description: Small molecule binding data for protein Neuronal acetylcholine receptor protein alpha-4/beta-2 subunit and alpha-1 Nicotinic AChR, Uniprot P02708, P17787, and P43681
DOI: 10.7270/q2zs2wfk
title: BindingDB Entry 50029031: TBA

description: Small molecule binding data for protein Inositol-1(or 4)-monophosphatase 1, Uniprot P20456
DOI: 10.7270/q20z738r
title: BindingDB Entry 50030066: TBA

description: Small molecule binding data for protein Cyclin-dependent kinase 1, Dual specificity mitogen-activated protein kinase kinase 1, Fibroblast growth factor receptor 1, Insulin receptor, MER intracellular domain/EGFR extracellular domain chimera, Mitogen-activated protein kinase; ERK1/ERK2, PDGFR-beta/Platelet-derived growth factor receptor alpha, Platelet-derived growth factor receptor (PDGFr), Platelet-derived growth factor receptor beta, Protein kinase C (PKC), VEGF-receptor 2 and tyrosine-protein kinase SRC, and cAMP-dependent protein kinase (PKA), Uniprot O94806, P00533, P05129, P05622, P05771, P06213, P06493, P09619, P11362, P12931, P16234, P17252, P17612, P22612, P22694, P24723, P26618, P27361, P28482, P41743, Q02156, Q02750, Q04759, Q05030, Q05513, Q05655, and Q15139
DOI: 10.7270/q22j6bsg
title: BindingDB Entry 50029042: TBA

description: Small molecule binding data for protein Squalene synthetase, Uniprot Q02769
DOI: 10.7270/q22r3rsc
title: BindingDB Entry 50031039: Evaluation of secondary amide replacements in a series of CCR5 antagonists as a means to increase intrinsic membrane permeability. Part 1: Optimization of gem-disubstituted azacycles.

description: Small molecule binding data for protein C-C chemokine receptor type 5, Uniprot P51681
DOI: 10.7270/q22v2g9f
title: BindingDB Entry 50032022: Smoothened antagonists for hair inhibition.

description: Small molecule binding data for protein 5-Hydroxytryptamine receptor 2A (5-HT2A), 5-Hydroxytryptamine receptor 7 (5-HT7), 5-hydroxytryptamine receptor 1A, Adrenergic alpha1B, Alpha-1A adrenergic receptor, Beta-1 adrenergic receptor, Beta-2 adrenergic receptor and beta-3 adrenergic receptor, Dopamine D1 and D2 receptor, Dopamine receptor D2L/neurotensin receptor NTS1, Dopamine receptors; D2 & D4, G-protein- coupled-like receptor Smoothened (Smo), Serotonin receptor (2b and 2c), and Voltage-gated potassium channel, Uniprot P07550, P08588, P08908, P14416, P21728, P21917, P28223, P34969, P35348, P35368, P41595, Q12809, and Q99835
DOI: 10.7270/q24q7v03
title: BindingDB Entry 50030065: TBA

description: Small molecule binding data for protein Fibroblast growth factor receptor and VEGF-receptor 2 and tyrosine-protein kinase SRC, Uniprot P11362, P12931, P21802, P22455, and P22607
DOI: 10.7270/q26973gr
title: BindingDB Entry 50029041: TBA

description: Small molecule binding data for protein Angiotensin II receptor and Angiotensin II type 1a (AT-1a) receptor, Uniprot P34976 and P35351
DOI: 10.7270/q26h4hh3
title: BindingDB Entry 50031038: Synthesis and biological activity of a potent and orally bioavailable SCD inhibitor (MF-438).

description: Small molecule binding data for protein Cytochrome P450 2D6 (2D6), Cytochrome P450 3A, and Stearoyl-CoA desaturase 1 (SCD1), Uniprot P07308, P08684, and P10635
DOI: 10.7270/q26m370q
title: BindingDB Entry 50032021: A newly synthesized, potent tyrosinase inhibitor: 5-(6-hydroxy-2-naphthyl)-1,2,3-benzenetriol.

description: Small molecule binding data for protein Tyrosinase, Uniprot O42713
DOI: 10.7270/q2930t28
title: BindingDB Entry 50029052: TBA

description: Small molecule binding data for protein Sigma, Uniprot Q99720
DOI: 10.7270/q298873f
title: BindingDB Entry 50031045: 2,3,5-Trisubstituted pyridines as selective AKT inhibitors. Part II: Improved drug-like properties and kinase selectivity from azaindazoles.

description: Small molecule binding data for protein AKT/p21CIP1, Cytochrome P450 1A, Cytochrome P450 2C19, Cytochrome P450 2C9, Cytochrome P450 2D6 (2D6), Cytochrome P450 3A, Glycogen synthase kinase-3, PAK1, Pyruvate dehydrogenase kinase isoenzyme 1 (PDK1), Rho-associated protein kinase, Ribosomal protein S6 kinase (P70S6K), and Serine/threonine-protein kinase AKT, Uniprot P05177, P08684, P10635, P11712, P23443, P31749, P31751, P33261, P49841, Q13153, Q13464, Q15118, and Q9Y243
DOI: 10.7270/q2b8586c
title: BindingDB Entry 50031037: Identification of a new class of small molecule C5a receptor antagonists.

description: Small molecule binding data for protein C-X-C chemokine receptor type 4 (CXCR4), C5a anaphylatoxin chemotactic receptor, C5a anaphylatoxin chemotactic receptor (C5aR), Purinergic receptor P2Y2, and chemokine (C-X-C motif) receptor 3, Uniprot P21730, P41231, P49682, P61073, and P97520
DOI: 10.7270/q2b858b5
title: BindingDB Entry 50032020: GPR109a agonists. Part 2: pyrazole-acids as agonists of the human orphan G-protein coupled receptor GPR109a.

description: Small molecule binding data for protein Hydroxycarboxylic acid receptor 2, Uniprot Q8TDS4 and Q9EP66
DOI: 10.7270/q2d79bdp
title: BindingDB Entry 50030063: TBA

description: Small molecule binding data for protein 1,3-beta-glucan synthase component GLS2, Uniprot P40989
DOI: 10.7270/q2dv1js8
title: BindingDB Entry 50029051: TBA

description: Small molecule binding data for protein EDNRB, Endothelin receptor ET-A, and Voltage-gated L-type calcium channel, Uniprot P21451, P22002, P27732, and Q29010
DOI: 10.7270/q2f18zsx
title: BindingDB Entry 50031044: Isoxazolopyridone derivatives as allosteric metabotropic glutamate receptor 7 antagonists.

description: Small molecule binding data for protein Metabotropic glutamate receptor 7 (mGlu7), Uniprot P35400
DOI: 10.7270/q2hx1cpg
title: BindingDB Entry 50030062: TBA

description: Small molecule binding data for protein Tyrosine-protein kinase ZAP-70, Uniprot P43403
DOI: 10.7270/q2jm29jf
title: BindingDB Entry 50029049: TBA

description: Small molecule binding data for protein Neurokinin 1 receptor, Uniprot P25103
DOI: 10.7270/q2js9qhb
title: BindingDB Entry 50031043: Discovery of (pyridin-4-yl)-2H-tetrazole as a novel scaffold to identify highly selective matrix metalloproteinase-13 inhibitors for the treatment of osteoarthritis.

description: Small molecule binding data for protein A disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAMTS-4), A disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS-5), ADAM17, Collagenase, Matrix Metalloproteinase-8 (MMP-8), Matrix metalloproteinase 15, Matrix metalloproteinase 16, Matrix metalloproteinase 26, Matrix metalloproteinase-1 (MMP1), Matrix metalloproteinase-12 (MMP12), Matrix metalloproteinase-14 (MMP14), Matrix metalloproteinase-24, Matrix metalloproteinase-25, Matrix metalloproteinase-7 (MMP7), and Stromelysin-1, Uniprot O75173, P03956, P08253, P08254, P09237, P14780, P22894, P39900, P45452, P50281, P51511, P51512, P78536, Q9NPA2, Q9NRE1, Q9UNA0, and Q9Y5R2
DOI: 10.7270/q2js9qmp
title: BindingDB Entry 50032026: Synthesis and structure-activity relationship of N-(3-azabicyclo[3.1.0]hex-6-ylmethyl)-5-(2-pyridinyl)-1,3-thiazol-2-amines derivatives as NPY Y5 antagonists.

description: Small molecule binding data for protein Cytochrome P450 1A, Cytochrome P450 2C19, Cytochrome P450 2C9, Cytochrome P450 3A, Neuropeptide Y receptor type 1, Neuropeptide Y receptor type 2, Neuropeptide Y receptor type 5 ( NPY Y5), and Voltage-gated potassium channel, Uniprot P05177, P08684, P11712, P25929, P33261, P49146, Q12809, and Q15761
DOI: 10.7270/q2kk9bqq
title: BindingDB Entry 50029036: TBA

description: Small molecule binding data for protein Trypanothione reductase, Uniprot P28593
DOI: 10.7270/q2ks6rqm
title: BindingDB Entry 50032017: Selective delivery of 2-hydroxy APA to Trypanosoma brucei using the melamine motif.

description: Small molecule binding data for protein Ornithine decarboxylase, Uniprot P09057
DOI: 10.7270/q2np24d6
title: BindingDB Entry 50030060: TBA

description: Small molecule binding data for protein Adrenergic receptor alpha-2, Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor, and Serotonin (5-HT) receptor, Uniprot P15823, P19327, P19328, P22086, P22909, P23944, and P43140
DOI: 10.7270/q2pc329m
title: BindingDB Entry 50029048: TBA

description: Small molecule binding data for protein Monoamine oxidase, Uniprot P21398 and P56560
DOI: 10.7270/q2pk0g7m
title: BindingDB Entry 50031042: Chemical lead optimization of a pan G(q) mAChR M(1), M(3), M(5) positive allosteric modulator (PAM) lead. Part I: Development of the first highly selective M(5) PAM.

description: Small molecule binding data for protein Muscarinic acetylcholine receptor, Muscarinic acetylcholine receptor M1, Muscarinic acetylcholine receptor M1/M5 chimeric protein, Muscarinic acetylcholine receptor M4, and Muscarinic receptor M2 and M3, Uniprot P08482, P08485, P08912, P10980, and P20309
DOI: 10.7270/q2pk0g9h
title: BindingDB Entry 50032025: Synthesis of potent chemical inhibitors of dynamin GTPase.

description: Small molecule binding data for protein Dynamin-1, Uniprot Q05193
DOI: 10.7270/q2sf2w50
title: BindingDB Entry 50030059: TBA

description: Small molecule binding data for protein Histamine H1 receptor and Neurokinin 1 receptor, Uniprot P30547 and P35367
DOI: 10.7270/q2t43t1z
title: BindingDB Entry 50029046: TBA

description: Small molecule binding data for protein 5-lipoxygenase/FLAP, Uniprot P09917
DOI: 10.7270/q2tb170s
title: BindingDB Entry 50031041: Evaluation of human neutrophil elastase inhibitory effect of iridoid glycosides from Hedyotis diffusa.

description: Small molecule binding data for protein Leukocyte elastase, Uniprot P08246
DOI: 10.7270/q2tb172p
title: BindingDB Entry 50032024: Discovery of potent, selective, and orally bioavailable 3H-spiro[isobenzofuran-1,4'-piperidine] based melanocortin subtype-4 receptor agonists.

description: Small molecule binding data for protein Melanocortin receptor 3 (MC3R), Melanocortin receptor 4, Melanocortin receptor 5 (MC5R), and Melatonin receptor, Uniprot P32245, P33032, P41968, P49286, P56450, and P70596
DOI: 10.7270/q2x63mz6
title: BindingDB Entry 50030057: TBA

description: Small molecule binding data for protein Coagulation factor X, Coagulation factor X/antithrombin III, Prothrombin, and Trypsin-1, Uniprot P00734, P00742, P00743, and P07477
DOI: 10.15156/bio/sh0935746.10fu
title: SH0935746.10FU

description: UNITE provides a unified way for delimiting, identifying, communicating, and working with DNA-based Species Hypotheses (SH). All fungal ITS sequences in the international nucleotide sequence databases are clustered to approximately the species level by applying a set of dynamic distance values (<0.5 - 3.0%). All species hypotheses are given a unique, stable name in the form of a DOI, and their taxonomic and ecological annotations are verified through distributed, web-based third-party annotation efforts. SHs are connected to a taxon name and its classification as far as possible (phylum, class, order, etc.) by taking into account identifications for all sequences in the SH. An automatically or manually designated sequence is chosen to represent each such SH. These sequences are released (https://unite.ut.ee/repository.php) for use by the scientific community in, for example, local sequence similarity searches and next-generation sequencing analysis pipelines. The system and the data are updated automatically as the number of public fungal ITS sequences grows.
DOI: 10.15156/bio/sh0935747.10fu
title: SH0935747.10FU

description: UNITE provides a unified way for delimiting, identifying, communicating, and working with DNA-based Species Hypotheses (SH). All fungal ITS sequences in the international nucleotide sequence databases are clustered to approximately the species level by applying a set of dynamic distance values (<0.5 - 3.0%). All species hypotheses are given a unique, stable name in the form of a DOI, and their taxonomic and ecological annotations are verified through distributed, web-based third-party annotation efforts. SHs are connected to a taxon name and its classification as far as possible (phylum, class, order, etc.) by taking into account identifications for all sequences in the SH. An automatically or manually designated sequence is chosen to represent each such SH. These sequences are released (https://unite.ut.ee/repository.php) for use by the scientific community in, for example, local sequence similarity searches and next-generation sequencing analysis pipelines. The system and the data are updated automatically as the number of public fungal ITS sequences grows.
DOI: 10.15156/bio/sh0935748.10fu
title: SH0935748.10FU

description: UNITE provides a unified way for delimiting, identifying, communicating, and working with DNA-based Species Hypotheses (SH). All fungal ITS sequences in the international nucleotide sequence databases are clustered to approximately the species level by applying a set of dynamic distance values (<0.5 - 3.0%). All species hypotheses are given a unique, stable name in the form of a DOI, and their taxonomic and ecological annotations are verified through distributed, web-based third-party annotation efforts. SHs are connected to a taxon name and its classification as far as possible (phylum, class, order, etc.) by taking into account identifications for all sequences in the SH. An automatically or manually designated sequence is chosen to represent each such SH. These sequences are released (https://unite.ut.ee/repository.php) for use by the scientific community in, for example, local sequence similarity searches and next-generation sequencing analysis pipelines. The system and the data are updated automatically as the number of public fungal ITS sequences grows.
DOI: 10.15156/bio/sh0935749.10fu
title: SH0935749.10FU

description: UNITE provides a unified way for delimiting, identifying, communicating, and working with DNA-based Species Hypotheses (SH). All fungal ITS sequences in the international nucleotide sequence databases are clustered to approximately the species level by applying a set of dynamic distance values (<0.5 - 3.0%). All species hypotheses are given a unique, stable name in the form of a DOI, and their taxonomic and ecological annotations are verified through distributed, web-based third-party annotation efforts. SHs are connected to a taxon name and its classification as far as possible (phylum, class, order, etc.) by taking into account identifications for all sequences in the SH. An automatically or manually designated sequence is chosen to represent each such SH. These sequences are released (https://unite.ut.ee/repository.php) for use by the scientific community in, for example, local sequence similarity searches and next-generation sequencing analysis pipelines. The system and the data are updated automatically as the number of public fungal ITS sequences grows.