cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.24131589.v1
title: Supplementary Material for: Venetoclax–azacitidine bridging PTCy-haplo-PBSCT for refractory acute myeloid leukemia with IDH2 mutations

description: Venetoclax and azacitidine combination therapy (VEN+AZA) is a promising novel therapy for elderly or unfit patients with acute myeloid leukemia (AML). Recently, VEN+AZA with subsequent allo-hematopoietic stem cell transplantation (allo-HSCT) has been reported, and human leukocyte antigen (HLA)-haploidentical peripheral blood stem cell transplantation using post-transplant cyclophosphamide (PTCy-haplo-PBSCT) from related donors appears to be a suitable option. Here, we report two elderly patients with refractory AML harboring an IDH2 mutation, which was successfully treated with VEN+AZA bridged to PTCy-haplo-PBSCT. This report suggests the efficacy and safety of VEN+AZA as a bridging treatment for PTCy-haplo-PBSCT in refractory AML.
DOI: 10.5281/zenodo.8196990
title: Supporting data for "Population Genomics of Postglacial Western Eurasia"

description: This repository contains supplemental data from Allentoft, Sikora et al. "Population Genomics of Postglacial Western Eurasia". The following files are included supplementary_figures/ Hi-res versions of supplementary figures ibd/ Aggregate total IBD sharing rates between pairs of individuals in the full dataset. Includes auxiliary metadata files to use for IBD-based mixture models (code available at https://github.com/martinsikora/mixmodel_ibd) For additional details on data generation, curation and sample metadata please consult the main paper.
DOI: 10.5281/zenodo.8196989
title: Supporting data for "Population Genomics of Postglacial Western Eurasia"

description: This repository contains supplemental data from Allentoft, Sikora et al. "Population Genomics of Postglacial Western Eurasia". The following files are included supplementary_figures/ Hi-res versions of supplementary figures ibd/ Aggregate total IBD sharing rates between pairs of individuals in the full dataset. Includes auxiliary metadata files to use for IBD-based mixture models (code available at https://github.com/martinsikora/mixmodel_ibd) For additional details on data generation, curation and sample metadata please consult the main paper.
DOI: 10.6084/m9.figshare.24155526.v1
title: Supplementary Material for: MicroRNA-9-1 Attenuates Influenza A Virus Replication via Targeting Tankyrase 1

description: An unstable influenza genome leads to the virus resistance to antiviral drugs that target viral proteins. Thus, identification of host factors essential for virus replication may pave the way to develop novel antiviral therapies. In this study, we investigated the roles of the poly(ADP-ribose) polymerase enzyme, tankyrase1 (TNKS1) and the endogenous small noncoding RNA, miR-9-1 in influenza A virus (IAV) infection. Increased expression of TNKS1 was observed in IAV-infected human lung epithelial cells and mouse lungs. TNKS1 knock-down by RNA interference repressed influenza viral replication. A screen using TNKS1 3’-untranslation region (3’-UTR) reporter assays and predicted microRNAs identified that miR-9-1 targeted TNKS1. Overexpression of miR-9-1 reduced influenza viral replication in lung epithelial cells as measured by viral mRNA and protein levels as well as virus production. miR-9-1 induced type I interferon production and enhanced the phosphorylation of STAT1 in cell culture. The ectopic expression of miR-9-1 in the lungs of mice by using an adenoviral viral vector enhanced type I interferon response, inhibited viral replication and reduced susceptibility to IAV infection. Our results indicate that miR-9-1 is an antiinfluenza microRNA that targeting TNKS1 and enhanced cellular antiviral state.
DOI: 10.6084/m9.figshare.24006390
title: Supplementary Material for: Refining a multifaceted model of perceived utility of genomic sequencing results

description: Introduction: Research on the perceived utility of genomic sequencing has focused primarily on pediatric populations and on individuals and families with rare genetic diseases. Here, we evaluate how well a multifaceted perceived utility model developed with these populations applies to a diverse, adult population aged 18-49 at risk for hereditary cancer and propose new considerations for the model. Methods: Participants received clinical genomic sequencing in the Cancer Health Assessments Reaching Many (CHARM) study. Semi-structured qualitative interviews were conducted with a subset of participants at one and six months after results disclosure. We used an approach influenced by grounded theory to examine perceptions of the utility of genomic sequencing and analyzed how utility in CHARM mapped to the published multifaceted perceived utility model, noting which domains were represented or absent, and which were most salient to our population. Results: Participants’ discussions of utility often involved multiple domains and revealed the variety of ways in which receiving sequencing results can impact one’s life. Results demonstrated that an individual’s perception of utility can change over the life course when sequenced at a relatively young age and may be influenced by the resources available to them to act on the results. Discussion/Conclusion: Our findings demonstrate the relevance of a multifaceted perceived utility model for a diverse adult population at risk for hereditary cancer. We identified refinements that could make the model more robust, including emphasizing the overlapping nature of the domains, and the importance of life stage and personal resources to the perception of utility.
DOI: 10.6084/m9.figshare.24006390.v1
title: Supplementary Material for: Refining a multifaceted model of perceived utility of genomic sequencing results

description: Introduction: Research on the perceived utility of genomic sequencing has focused primarily on pediatric populations and on individuals and families with rare genetic diseases. Here, we evaluate how well a multifaceted perceived utility model developed with these populations applies to a diverse, adult population aged 18-49 at risk for hereditary cancer and propose new considerations for the model. Methods: Participants received clinical genomic sequencing in the Cancer Health Assessments Reaching Many (CHARM) study. Semi-structured qualitative interviews were conducted with a subset of participants at one and six months after results disclosure. We used an approach influenced by grounded theory to examine perceptions of the utility of genomic sequencing and analyzed how utility in CHARM mapped to the published multifaceted perceived utility model, noting which domains were represented or absent, and which were most salient to our population. Results: Participants’ discussions of utility often involved multiple domains and revealed the variety of ways in which receiving sequencing results can impact one’s life. Results demonstrated that an individual’s perception of utility can change over the life course when sequenced at a relatively young age and may be influenced by the resources available to them to act on the results. Discussion/Conclusion: Our findings demonstrate the relevance of a multifaceted perceived utility model for a diverse adult population at risk for hereditary cancer. We identified refinements that could make the model more robust, including emphasizing the overlapping nature of the domains, and the importance of life stage and personal resources to the perception of utility.
DOI: 10.1285/i20705948v16n1p1
title: The use of PLS-PM to analyze progress testing results: the case of Italian degree courses in Dentistry and Dental Prosthodontics

description: Progress testing is a longitudinal approach based on equivalent tests given at ﬁxed intervals with the intention of assessing the development of functional knowledge or competence. The longitudinal integrated assessment approach has a demonstrable positive effect on student learning behavior. Furthermore, it leads to more reliable decisions as well as having a good predictive validity for future competence or the retention of knowledge. The aim of this paper, on the one hand, is to offer a new perspective on the analysis of progress testing through the use of a growth curve and, on the other, to demonstrate how Partial Least Square Path Modeling can help us to analyze the growth curve. Longitudinal data from progress testing at Italian Dental Schools are analyzed by using a Partial Least Square Path Modeling latent growth curve approach.
DOI: 10.1285/i20705948v16n1p25
title: Human Resources Practices Management and Job Satisfaction: the Moderating Role of Seeking Challenges. A Longitudinal Study Through PLS-SEM

description: The current labour market needs sustainable organisations in human, technological and environmental terms. The rapid transformations that take place on a daily basis, and the constant search for personnel with transversal competences, lead to a rethinking of the resources needed for the development of organisations and organizational well-being. The objective of this research is to analyse the impact of Human Resources Management practices on job satisfaction and on the moderator role of proactive seeking challenges skills on this relationship. The study was carried out on 152 subjects, about 60% female and 40% male, with prevalent age in the class between 35 and 50 years. The results obtained by means of non-parametric Structural Equation Models (PLS-SEM) indicate that Human Resources practices showed a positive relationship with proactive challenge seeking behaviour (job crafting) and job satisfaction at Time 2. The estimates were validated by bootstrap resampling performed through 1000 resubmissions. In addition, the study highlights the moderating role of seeking challenges in the relationship between Human Resources Management practices and job satisfaction. The evidence provide important reflection, as it leads to rethinking strategically the adoption of appropriate practices to manage the workforce, ensuring personal growth and quality of organizational life and well-being.
DOI: 10.34740/kaggle/dsv/6519103
title: Global Genomic Neurofibromatosis Neoplasia
DOI: 10.6084/m9.figshare.23899608.v1
title: Supplementary Material for: Possible Influence of Ethnicity on CT Perfusion Parameter Thresholds in Acute Ischemic Stroke

description: Introduction Tissue at risk, as estimated by CT perfusion utilizing Tmax+6, correlates with final infarct volume (FIV) in acute ischemic stroke (AIS) without reperfusion. Tmax thresholds are derived from Western ethnic populations but not from ethnic Asian populations. We aimed to investigate the influence of ethnicity on Tmax thresholds. Methods From a clinical-imaging registry of Australian and Indonesian stroke patients, we selected a participant subgroup with the following inclusion criteria: AIS under 24 hours and absence of reperfusion therapy. Clinical data included demographics, time metrics, stroke severity, premorbid, and 3-month Modified Rankin Score. Baseline CTP and MRI &lt;72 hours were performed. Volumes of Tmax utilizing different thresholds and final infarct volumes (FIV) were calculated. Spearman correlation was used to evaluate relationship involving ordinal variables and calculate the optimal Tmax threshold against FIV in both populations. Results Two hundred patients were included in the study sample 100 in Jakarta and 100 in Geelong. The median National Institutes Health Stroke Scale (IQR) were 6(3-11) and 3(1-5), respectively. The median Tmax+6(IQR) was 0 (0-46.5) in Jakarta group and 0(0-7.5) in Geelong group. The median FIV(IQR) was 0 (0-30.5) and 0 (0-5.5). Tmax +8s in Jakarta population against FIV showed Spearman’s coefficient =0.72, representing the optimal Tmax threshold. Tmax+6s showed Spearman’s coefficient =0.51 against FIV in the Geelong population. Conclusions Tmax thresholds approximating FIV were possibly different in the Asian when compared with the non-Asian populations. Future studies are required to extend and confirm the validity of our findings.
DOI: 10.1285/i20705948v16n1p50
title: Stakeholder's Perception on Malaysia's Edu-Tourism Sustainability Performance

description: This study shows that Edu-Tourism is manageable by considering various sustainability indicators that are identified from the evaluation of international students' satisfaction. Differ from past sustainable tourism researches which usually investigate the tourism supply side of stakeholders (economics, social and environmental), this study adds value to the sustainable tourism literature by examining the tourism demand side of stakeholders (tourist satisfaction). Generally, Malaysia Edu-Tourism is operating within "potentially sustainable" category, improvements are needed to achieve "sustainable" status. Six indicators (reputation of university, perceived faculty academic competence, student-student interactions, perceived quality of faculty communications, climate and study environment, information availability) are moderately performed. Best performer being perceived quality of electronic communications and student-admin interaction. Worst performer being social links and geographic proximity. A quantitative research approach was used in this study where questionnaires were distributed for data collection. The sample size of the study consisted of 264 international students of different public and private sector universities. Structural Equation Model using SMARTPLS was used to identify significant indicators and then descriptive analysis was performed to evaluate sustainability of Malaysia Edu-Tourism sector. The article concludes with a discussion of the research and implications of the study along with suggestions for future research.
DOI: 10.1285/i20705948v16n1p80
title: Purchase Intention of Made-in-China Medical Devices among Malaysians: Does COO Effect Work?

description: Made-in-China products are getting popular around the world. Overcoming the 'low quality' perception or unfavorable country of origin (COO) effect is imperative not only for China marketers but also for any related business in other markets. Despite their huge popularity, understanding of market responses and perceptions towards China products remain unclear, especially in the technology-advanced healthcare sector. Based on the Theory of Reasoned Action (TRA) and COO effect, this study examined how subjective norms, self-image congruence and stereotype affected Malaysian consumers' attitude and purchase intention of Made-in-China medical devices. 200 questionnaires in total were distributed among buyers in Malaysian public and private hospitals. A total of 178 valid responses were collected adopting purposive sampling technique. Findings indicated a significant impact of consumer attitude on purchase intention and attitude was found to be driven by subjective norms and stereotypes (warmth and competence), but not self-image congruency. The study also showed significant mediating effects of consumer attitude on the relationship between subjective norms and stereotype (competence) on purchase intention. The findings provide valuable insights to assist marketers in tapping into the Made-in-China medical device market as well as helping healthcare agencies plan and implement effective policy and marketing communication strategies.
DOI: 10.18112/openneuro.ds004569.v1.0.0
title: A high-density diffuse optical tomography dataset of naturalistic viewing
DOI: 10.1285/i20705948v16n1p139
title: How Memorable is Halal Tourism in Japan and the United Kingdom?

description: The provision of halal products and services for Muslim tourists would be a competitive edge for tourism destinations as the Muslim population is increasing. This research examines halal-friendly attributes provided by non-Muslim country destinations (Japan and UK) and determines their roles in creating memorable tourism experiences and driving behavioral intentions. The questionnaire was collected from 349 Muslim tourists who have visited UK or Japan once in the last two years. Underpinned by Script theory and Stimulus-Organism-Response theory, the proposed structural model was found to adequately describe the variance in memorable tourism experience and behavioral intention of Muslim tourists; four attributes (halal food and beverages, enhancement of halal experiences, halal-friendly hotels, and halal-friendly social environment) were positively related to memorable tourism experience and recommend intention, and all five attributes including halal-friendly services information had a significant influence on revisit intention of Muslim tourists. In addition, a memorable tourism experience is a significant mediator linking four halal-friendly attributes (except halal-friendly services information) and behavioral intention.
DOI: 10.5281/zenodo.7683774
title: Simulation outputs of DynSoM model and instrumental data for Samoylov Island's polygonal tundra

description: These datasets include the observational data, the input parameters, and the Dynamic Soil Model (DynSoM) outputs of a polygonal tundra arctic environment located in the quaternary sediments of Samoylov island, with and without considering heave due the segregation of ice. The data is gathered (SamValidation.mat) and simulated at the centre and rim of one of the polygons, which correspond to wet and dry tundra conditions respectively. This dataset Is used as a primary data input for the simulation and output for the figures of the article "Mechanistic Modelling of Segregated Ice and Soil Heave Dynamics in Artic Soils" by Xavier Rodriguez-Lloveras, Melanie A. Thurner Philipp Porada & Christian Beer, Universität Hamburg. Submitted to "The Journal of Advances in Modeling Earth Systems (JAMES)" on February 2023. The datasets are published as MATLAB matrix format and require adequate MATLAB (or equivalent) software for visualization. The validation data (SamValidation.mat) is a subset of the data published by Boike et al. (2019, doi:10.1594/PANGAEA.905236) adapted to the DynSoM model requirements.
DOI: 10.5281/zenodo.7683775
title: Simulation outputs of DynSoM model and instrumental data for Samoylov Island's polygonal tundra

description: These datasets include the observational data and the Dynamic Soil Model (DynSoM) outputs of a polygonal tundra artic environment located in the quaternary sediments of Samoylov island. the data is gathered (SamValidation.mat) and simulated at the centre (output_center.mat) and rim (output_rim.mat) of one of the polygons, which correspond to wet and dry tundra conditions respectively. This dataset Is used as a primary data output for the figures of the article "Mechanistic Modelling of Segregated Ice and Soil Heave Dynamics in Artic Soils" by Xavier Rodriguez-Lloveras, Melanie A. Thurner Philipp Porada & Christian Beer, Universität Hamburg. Submitted to "The Journal of Advances in Modeling Earth Systems (JAMES)" on February 2023. The datasets are published as MATLAB matrix format and require adequate MATLAB (or equivalent) software for visualization. The validation data (SamValidation.mat) is a subset of the data published by Boike et al. (2019, doi:10.1594/PANGAEA.905236) adapted to the DynSoM model requirements.
DOI: 10.5281/zenodo.8370106
title: Simulation outputs of DynSoM model and instrumental data for Samoylov Island's polygonal tundra

description: These datasets include the observational data, the input parameters, and the Dynamic Soil Model (DynSoM) outputs of a polygonal tundra arctic environment located in the quaternary sediments of Samoylov island, with and without considering heave due the segregation of ice. The data is gathered (SamValidation.mat) and simulated at the centre and rim of one of the polygons, which correspond to wet and dry tundra conditions respectively. This dataset Is used as a primary data input for the simulation and output for the figures of the article "Mechanistic Modelling of Segregated Ice and Soil Heave Dynamics in Artic Soils" by Xavier Rodriguez-Lloveras, Melanie A. Thurner Philipp Porada & Christian Beer, Universität Hamburg. Submitted to "The Journal of Advances in Modeling Earth Systems (JAMES)" on February 2023. The datasets are published as MATLAB matrix format and require adequate MATLAB (or equivalent) software for visualization. The validation data (SamValidation.mat) is a subset of the data published by Boike et al. (2019, doi:10.1594/PANGAEA.905236) adapted to the DynSoM model requirements.
DOI: 10.5281/zenodo.8298868
title: Fine mapping of 5 chronic pain types

description: Fine mapping was run with CAUSALdb-finemapping-pip using clumped GWAS data of 5 chronic pain types: chronic neck, back, hip and knee pain and chronic headaches.
DOI: 10.5281/zenodo.8298867
title: Fine mapping of 5 chronic pain types

description: Fine mapping was run with CAUSALdb-finemapping-pip using clumped GWAS data of 5 chronic pain types: chronic neck, back, hip and knee pain and chronic headaches.
DOI: 10.5281/zenodo.8055118
title: Gene-based association analysis on 7 chronic pain types

description: Gene-based association testing was run GCTA-fastBAT package on 7 phenotypes: chronic back, neck, hip, knee, facial, and abdominal pain and chronic headache. The summary statistics used to produce the text files required for this analysis have also been uploaded.
DOI: 10.5281/zenodo.8055117
title: Gene-based association analysis on 7 chronic pain types

description: Gene-based association testing was run GCTA-fastBAT package on 7 phenotypes: chronic back, neck, hip, knee, facial, and abdominal pain and chronic headache. The summary statistics used to produce the text files required for this analysis have also been uploaded.
DOI: 10.5281/zenodo.8370110
title: Dataset for study Long-term changes in urban bird populations: correspondence of the trends between urban and rural areas

description: Dataset used for a study "Long-term changes in urban bird populations: correspondence of the trends between urban and rural areas" Data structure: Type = type of environment (R - rural, U - urban)<br> POID = unique identifier of each census point across all transects<br> Transect = unique identifier of a transect (each contains 20 census points)<br> Point = unique identifier of a point within one transect<br> Year = year of the count<br> Species = scientific name of bird species<br> Count = number of birds counted Each species has its own datafile.
DOI: 10.5281/zenodo.8370109
title: Dataset for study Long-term changes in urban bird populations: correspondence of the trends between urban and rural areas

description: Dataset used for a study "Long-term changes in urban bird populations: correspondence of the trends between urban and rural areas" Data structure: Type = type of environment (R - rural, U - urban)<br> POID = unique identifier of each census point across all transects<br> Transect = unique identifier of a transect (each contains 20 census points)<br> Point = unique identifier of a point within one transect<br> Year = year of the count<br> Species = scientific name of bird species<br> Count = number of birds counted Each species has its own datafile.
DOI: 10.5281/zenodo.8368674
title: Pathway enrichment of 5 chronic pain types

description: Pathway enrichment analysis was performed on the phenotypes investigated in our study: chronic neck, back, hip and knee pain and chronic headaches. The VEGAS2Pathway tool was used.
DOI: 10.5281/zenodo.8368673
title: Pathway enrichment of 5 chronic pain types

description: Pathway enrichment analysis was performed on the phenotypes investigated in our study: chronic neck, back, hip and knee pain and chronic headaches. The VEGAS2Pathway tool was used.