cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.3505013
title: Supplementary Material for: Necitumumab plus Gemcitabine and Cisplatin as First-Line Therapy in Patients with Stage IV EGFR- Expressing Squamous Non-Small-Cell Lung Cancer: German Subgroup Data from an Open-Label, Randomized Controlled Phase 3 Study (SQUIRE)

description: Background: In the SQUIRE study, adding the antiepidermal growth factor receptor (EGFR) IgG1 antibody necitumumab to first-line gemcitabine and cisplatin (GC + N) in advanced squamous non-small-cell lung cancer (sqNSCLC) significantly improved overall survival (OS); the safety profile was acceptable. We explored data for the German subpopulation (N = 96) of SQUIRE patients with EGFR-expressing tumors. Patient and Methods: Patients with stage IV sqNSCLC were randomized 1:1 to up to 6 cycles of open-label GC + N or GC alone. GC + N patients with no progression continued on necitumumab monotherapy until disease progression or intolerable toxicity. The primary endpoint was OS; the secondary endpoints included progression-free survival (PFS), safety and health-related quality of life (EQ-5D, Lung Cancer Symptom Scale (LCSS)). Results: The 96 German SQUIRE patients with EGFR-expressing tumors (GC + N 42, GC 54) received a median of 4 GC cycles; the GC + N patients received 5 cycles of necitumumab. Adding necitumumab was associated with 41% risk reduction of death (hazard ratio (HR) 0.59, 95% confidence interval (CI) 0.37–0.94, p = 0.026) and 44% risk reduction of progression (HR 0.56, 95% CI 0.33–0.95, p = 0.029). Adverse events typically associated with EGFR antibody treatment (including rash, hypomagnesemia) were more common with GC + N. The time to deterioration of the EQ-5D and LCSS scores showed no notable differences between the treatment arms, except for appetite loss (delayed for GC + N). Conclusion: The survival benefit from adding necitumumab to first-line GC was more pronounced in the German SQUIRE subpopulation with EGFR-expressing tumors than in the overall (intentionto-treat) population; toxicity was manageable and consistent with the overall population.
DOI: 10.6084/m9.figshare.3505007
title: PowerPoint Slides for: Pharmacodynamic Effects of Sucroferric Oxyhydroxide and Sevelamer Carbonate on Vitamin D Receptor Agonist Bioactivity in Dialysis Patients

description: <i>Background:</i> Many patients with chronic kidney disease are prescribed vitamin D receptor agonists (VDRAs) for the management of secondary hyperparathyroidism. Oral phosphate binders may interact with, and potentially reduce the therapeutic activity of, oral VDRAs. This post hoc analysis of a Phase 3 study evaluated the pharmacodynamic effects of the iron-based phosphate binder sucroferric oxyhydroxide (SFOH) and sevelamer (SEV) carbonate on VDRA activity in dialysis patients. <i>Methods:</i> One thousand and fifty nine patients were randomized to SFOH 1.0-3.0 g/day (n = 710) or SEV 2.4-14.4 g/day (n = 349) for up to 52 weeks. Potential interactions of SFOH and SEV with VDRAs were assessed using serum intact parathyroid hormone (iPTH) concentrations as a pharmacodynamic biomarker. Three populations of SFOH- and SEV-treated patients were analyzed: Population 1 (n = 187), patients taking concomitant stable doses of oral VDRAs only; Population 2 (n = 250), patients taking no concomitant VDRAs; Population 3 (n = 68), patients taking concomitant stable doses of intravenous paricalcitol only. Populations were compared using a mixed-effects model to obtain the least squares mean change in iPTH from baseline to Week 52. Differences between treatment groups were also compared. <i>Results:</i> In Population 1, iPTH decreased from baseline to Week 52 in the SFOH group (-25.3 pg/ml) but increased in the SEV group (89.8 pg/ml) (p = 0.02). In Population 2, iPTH increased to a similar extent in both treatment groups. In Population 3, iPTH concentrations in both treatment groups decreased to a similar degree (-29.6 and -11.4 pg/ml for SFOH and SEV, respectively; p = 0.87). <i>Conclusions:</i>In contrast with SEV, SFOH did not appear to impact the iPTH-lowering effect of oral VDRAs.
DOI: 10.6084/m9.figshare.3505007.v1
title: PowerPoint Slides for: Pharmacodynamic Effects of Sucroferric Oxyhydroxide and Sevelamer Carbonate on Vitamin D Receptor Agonist Bioactivity in Dialysis Patients

description: <i>Background:</i> Many patients with chronic kidney disease are prescribed vitamin D receptor agonists (VDRAs) for the management of secondary hyperparathyroidism. Oral phosphate binders may interact with, and potentially reduce the therapeutic activity of, oral VDRAs. This post hoc analysis of a Phase 3 study evaluated the pharmacodynamic effects of the iron-based phosphate binder sucroferric oxyhydroxide (SFOH) and sevelamer (SEV) carbonate on VDRA activity in dialysis patients. <i>Methods:</i> One thousand and fifty nine patients were randomized to SFOH 1.0-3.0 g/day (n = 710) or SEV 2.4-14.4 g/day (n = 349) for up to 52 weeks. Potential interactions of SFOH and SEV with VDRAs were assessed using serum intact parathyroid hormone (iPTH) concentrations as a pharmacodynamic biomarker. Three populations of SFOH- and SEV-treated patients were analyzed: Population 1 (n = 187), patients taking concomitant stable doses of oral VDRAs only; Population 2 (n = 250), patients taking no concomitant VDRAs; Population 3 (n = 68), patients taking concomitant stable doses of intravenous paricalcitol only. Populations were compared using a mixed-effects model to obtain the least squares mean change in iPTH from baseline to Week 52. Differences between treatment groups were also compared. <i>Results:</i> In Population 1, iPTH decreased from baseline to Week 52 in the SFOH group (-25.3 pg/ml) but increased in the SEV group (89.8 pg/ml) (p = 0.02). In Population 2, iPTH increased to a similar extent in both treatment groups. In Population 3, iPTH concentrations in both treatment groups decreased to a similar degree (-29.6 and -11.4 pg/ml for SFOH and SEV, respectively; p = 0.87). <i>Conclusions:</i>In contrast with SEV, SFOH did not appear to impact the iPTH-lowering effect of oral VDRAs.
DOI: 10.6084/m9.figshare.3504977
title: Survey of undeclared soy allergen levels in the most frequently recalled food categories with or without precautionary labelling

description: A comprehensive study was designed to determine the frequency and levels of soy allergen in packaged bakery and snack food products. A representative sample of products with no soy allergen disclosed on the label was analysed using two widely used enzyme-linked immunosorbent assay (ELISA) methods. Samples were chosen that either had no soy identified on the product label or which had a soy precautionary statement. Among 558 bakery and snack products, soy protein was detected in 17% of the products using the Neogen (NE) kit and 11% of the products using the Elisa Systems (ES) kit. The disagreement rates between kits were 8.8% for bakery products and 3.3% for snack products. Overall soy protein was detected at higher frequency in bakery products than in snack foods. Among 284 bakery samples, soy protein was detected in 25% of the samples with no precautionary statement and 19% of the samples which had a precautionary statement. Among 274 snack samples, soy protein was detected in 11% of the samples with no precautionary statement and 9% of the samples which had a precautionary statement. The sample repeatability was at an acceptable level ( 5 ppm) had a higher level of soy protein per serving compared with the eliciting dose<sub>10</sub> (ED<sub>10</sub>) of 10.6 mg for soy allergic patients. But the level of soy protein per serving may be clinically relevant to a subpopulation of soy allergic patients if a more stringent eliciting dose is applied. These findings emphasise that suitable detection methodologies and references doses are crucial for labelling accuracy and the safety of soy allergic consumers.
DOI: 10.6084/m9.figshare.3504977.v1
title: Survey of undeclared soy allergen levels in the most frequently recalled food categories with or without precautionary labelling

description: A comprehensive study was designed to determine the frequency and levels of soy allergen in packaged bakery and snack food products. A representative sample of products with no soy allergen disclosed on the label was analysed using two widely used enzyme-linked immunosorbent assay (ELISA) methods. Samples were chosen that either had no soy identified on the product label or which had a soy precautionary statement. Among 558 bakery and snack products, soy protein was detected in 17% of the products using the Neogen (NE) kit and 11% of the products using the Elisa Systems (ES) kit. The disagreement rates between kits were 8.8% for bakery products and 3.3% for snack products. Overall soy protein was detected at higher frequency in bakery products than in snack foods. Among 284 bakery samples, soy protein was detected in 25% of the samples with no precautionary statement and 19% of the samples which had a precautionary statement. Among 274 snack samples, soy protein was detected in 11% of the samples with no precautionary statement and 9% of the samples which had a precautionary statement. The sample repeatability was at an acceptable level ( 5 ppm) had a higher level of soy protein per serving compared with the eliciting dose<sub>10</sub> (ED<sub>10</sub>) of 10.6 mg for soy allergic patients. But the level of soy protein per serving may be clinically relevant to a subpopulation of soy allergic patients if a more stringent eliciting dose is applied. These findings emphasise that suitable detection methodologies and references doses are crucial for labelling accuracy and the safety of soy allergic consumers.
DOI: 10.6084/m9.figshare.3504953
title: The enigma of intricately fitted beach boulders near Raglan, New Zealand

description: An intertidal rocky platform tucked in behind a rocky headland on open-ocean Gibson Beach, near Raglan, supports an agglomeration of cobble- to large-boulder-sized clasts of Cenozoic sandstone and limestone. Rather than exhibiting just point contacts, many larger clasts are tightly interlocked and fitted with their neighbours and/or the underlying platform bedrock. Clast interface geometry relates to the strength contrast between adjacent rock types, linked to their calcite (cement) content. The end-product is an armoured, highly stable framework of boulder clasts resembling a giant three-dimensional jigsaw puzzle. While the direct impact of breaking waves likely plays a role in in situ jostling of boulders, we speculate that mechanical abrasion and fitting between larger clasts may also be promoted and maintained by in situ microvibration of the boulders as a consequence of wave-induced microseismic shaking within the cliff-backed rocky platform and headland, especially during major storm wave assault from the southwest.
DOI: 10.6084/m9.figshare.3504953.v1
title: The enigma of intricately fitted beach boulders near Raglan, New Zealand

description: An intertidal rocky platform tucked in behind a rocky headland on open-ocean Gibson Beach, near Raglan, supports an agglomeration of cobble- to large-boulder-sized clasts of Cenozoic sandstone and limestone. Rather than exhibiting just point contacts, many larger clasts are tightly interlocked and fitted with their neighbours and/or the underlying platform bedrock. Clast interface geometry relates to the strength contrast between adjacent rock types, linked to their calcite (cement) content. The end-product is an armoured, highly stable framework of boulder clasts resembling a giant three-dimensional jigsaw puzzle. While the direct impact of breaking waves likely plays a role in in situ jostling of boulders, we speculate that mechanical abrasion and fitting between larger clasts may also be promoted and maintained by in situ microvibration of the boulders as a consequence of wave-induced microseismic shaking within the cliff-backed rocky platform and headland, especially during major storm wave assault from the southwest.
DOI: 10.6084/m9.figshare.3504947
title: Riparian management affects instream habitat condition in a dairy stream catchment

description: Using a space-for-time substitution design, we investigated the response of structural instream habitat and fish populations to different riparian management practices throughout a Dairy Best Practice Catchment. We found a significant negative correlation between the upstream area of stock exclusion fencing and deposited instream fine sediment cover. Furthermore, we determined that this relationship emerges when ≥300 m lengths of upstream riparian area were included in the analysis, indicating the scale at which stock exclusion fencing results in a positive instream habitat response. Specifically, for this historically degraded spring-fed stream, our findings indicate that riparian segments with 5 m wide stock exclusion fences (both banks) are required to achieve instream fine sediment cover below 20% in downstream reaches. Fish were sparse and evenly spread throughout the catchment. Fish distributions were not correlated with reach-scale riparian or instream habitat variables, possibly because the available habitat quality gradient was too narrow.
DOI: 10.6084/m9.figshare.3504947.v1
title: Riparian management affects instream habitat condition in a dairy stream catchment

description: Using a space-for-time substitution design, we investigated the response of structural instream habitat and fish populations to different riparian management practices throughout a Dairy Best Practice Catchment. We found a significant negative correlation between the upstream area of stock exclusion fencing and deposited instream fine sediment cover. Furthermore, we determined that this relationship emerges when ≥300 m lengths of upstream riparian area were included in the analysis, indicating the scale at which stock exclusion fencing results in a positive instream habitat response. Specifically, for this historically degraded spring-fed stream, our findings indicate that riparian segments with 5 m wide stock exclusion fences (both banks) are required to achieve instream fine sediment cover below 20% in downstream reaches. Fish were sparse and evenly spread throughout the catchment. Fish distributions were not correlated with reach-scale riparian or instream habitat variables, possibly because the available habitat quality gradient was too narrow.
DOI: 10.6084/m9.figshare.3504923
title: Late Cretaceous granitoids in Karakorum, northwest Tibet: petrogenesis and tectonic implications

description: New zircon LA-ICP-MS U–Pb age, zircon Hf isotope, and whole-rock major and trace elemental data of the Late Cretaceous Ageledaban complex in the Karakorum Terrane (KKT), northwest Tibet, provide new constraints on the tectonic processes of the collision and thickening of the terrane between the Lhasa and Qiangtang terranes. The granitoids from the Ageledaban complex have a variable SiO<sub>2</sub> content, from 62.83 to 73.35 wt.% and A/CNK&lt;1.1 (except for YM61-2). They have rare earth element and trace element patterns that are enriched in light rare earth elements, Rb, Pb, Th, and U, and are depleted in Ba, P, Sr, Ti, and Nb, indicative of weakly peraluminous-metaluminous I-type affinity. Zircon U–Pb dating reveals that the Ageledaban complex was emplaced at ca. 80 Ma. Zircons from the monzogranite and monzonite samples with concordant <sup>206</sup>Pb/<sup>238</sup>U ages about 80 Ma have a zircon <i>ε</i><sub>Hf</sub>(<i>t</i>) of −6.6 to −1.1, corresponding to the Mesoproterozoic Hf crustal model ages (T<sub>DM</sub><sup>C</sup> = 1.2–1.6 Ga); the remaining inherited zircons from the monzonite with concordant <sup>206</sup>Pb/<sup>238</sup>U ages of about 108.1 Ma have <i>ε</i><sub>Hf</sub>(<i>t</i>) values that range from −8.3 to −5.0, corresponding to the Mesoproterozoic Hf crustal model ages with an average of 1.6 Ga. These signatures indicate that the Ageledaban granitoids may have been derived from the partial melting of a mixed mantle-crust source. Together with the age and geochemical data in the literature, we propose that the collisional event in the KKT in northwestern Tibet would postdate the northern Lhasa–southern Qiangtang collision, which occurred first in the Amdo in the east and later in the Shiquanhe in central Tibet. Our results support the previous view that the collision of the Bangong–Nujiang suture zone (BNSZ) may be diachronous.
DOI: 10.6084/m9.figshare.3504914
title: Shape minimisation problems in liquid crystals

description: We consider a class of liquid crystal free-boundary problems for which both the equilibrium shape and internal configuration of a system must simultaneously be determined, for example in films with air–liquid or fluid–liquid crystal interfaces and elastomers. We develop a finite element algorithm to solve such problems with dynamic mesh control, achieved by supplementing the free energy with an auxiliary functional that promotes mesh quality and is minimised in the null space of the energy. We apply this algorithm to a flexible capacitor, as well as to determine the shape of liquid crystal tactoids as a function of the surface tension and elastic constants. These are compared with theoretical predictions and experimental observations of tactoids from the literature.
DOI: 10.6084/m9.figshare.3504914.v1
title: Shape minimisation problems in liquid crystals

description: We consider a class of liquid crystal free-boundary problems for which both the equilibrium shape and internal configuration of a system must simultaneously be determined, for example in films with air–liquid or fluid–liquid crystal interfaces and elastomers. We develop a finite element algorithm to solve such problems with dynamic mesh control, achieved by supplementing the free energy with an auxiliary functional that promotes mesh quality and is minimised in the null space of the energy. We apply this algorithm to a flexible capacitor, as well as to determine the shape of liquid crystal tactoids as a function of the surface tension and elastic constants. These are compared with theoretical predictions and experimental observations of tactoids from the literature.
DOI: 10.6084/m9.figshare.3504905
title: Non-electronic gas sensors from electrospun mats of liquid crystal core fibres for detecting volatile organic compounds at room temperature

description: Non-woven mats comprised of liquid crystal-functionalised fibres are coaxially electrospun to create soft gas sensors that function non-electronically, thus requiring no power supply, detecting organic vapours at room temperature. The fibres consist of a poly(vinylpyrrolidone) (PVP) sheath surrounding a core of nematic 4-cyano-4ʹpentylbiphenyl (5CB) liquid crystal. Several types of mats, containing uniformly cylindrical or irregular beaded fibres, in uniform or random orientations, are exposed to toluene vapour as a representative volatile organic compound. Between crossed polarisers all mats respond with a fast (response time on the order of a second or faster) reduction in brightness during gas exposure, and they return to the original state upon removal of the gas almost as quickly. With beaded fibres, the response of the mats is visible even without polarisers. We discuss how variations in fibre spinning conditions such as humidity level and the ratio of core-sheath fluid flow rates can be used to tune fibre morphology and thereby the response. Considering future development perspectives, we argue that fibres turned responsive through the incorporation of a liquid crystal core show promise as a new generation of sensors with textile form factor, ideal for wearable technology applications.
DOI: 10.6084/m9.figshare.12917216
title: preci_timeseries_box.mat

description: preci_timeseries_box.mat is the weekly time series of TRMM precipitation over the 13 boxed regions of interest spanning from 2006 to 2015.
DOI: 10.6084/m9.figshare.3504905.v1
title: Non-electronic gas sensors from electrospun mats of liquid crystal core fibres for detecting volatile organic compounds at room temperature

description: Non-woven mats comprised of liquid crystal-functionalised fibres are coaxially electrospun to create soft gas sensors that function non-electronically, thus requiring no power supply, detecting organic vapours at room temperature. The fibres consist of a poly(vinylpyrrolidone) (PVP) sheath surrounding a core of nematic 4-cyano-4ʹpentylbiphenyl (5CB) liquid crystal. Several types of mats, containing uniformly cylindrical or irregular beaded fibres, in uniform or random orientations, are exposed to toluene vapour as a representative volatile organic compound. Between crossed polarisers all mats respond with a fast (response time on the order of a second or faster) reduction in brightness during gas exposure, and they return to the original state upon removal of the gas almost as quickly. With beaded fibres, the response of the mats is visible even without polarisers. We discuss how variations in fibre spinning conditions such as humidity level and the ratio of core-sheath fluid flow rates can be used to tune fibre morphology and thereby the response. Considering future development perspectives, we argue that fibres turned responsive through the incorporation of a liquid crystal core show promise as a new generation of sensors with textile form factor, ideal for wearable technology applications.
DOI: 10.6084/m9.figshare.12917216.v1
title: preci_timeseries_box.mat

description: preci_timeseries_box.mat is the weekly time series of TRMM precipitation over the 13 boxed regions of interest spanning from 2006 to 2015.
DOI: 10.6084/m9.figshare.3504812
title: Polygala tenuifolia Willd

description: world occurrences of <i>P.tenuifolia</i><br>
DOI: 10.6084/m9.figshare.3504812.v1
title: Polygala tenuifolia Willd

description: world occurrences of <i>P.tenuifolia</i><br>
DOI: 10.6084/m9.figshare.3504785
title: Effect of genotype, medium and light on in vitro plant proliferation of <i>Vaccinium</i> spp.

description: The aim of this study was to investigate how growing conditions and media enhance blueberry proliferation. The effects of combinations of five <i>Vaccinium</i> spp. genotypes, two growing conditions and four proliferation media on plant growth were investigated. For shoot length and number of shoots, the factor responsible for the majority of the variance was the medium (13% and 22%, respectively). For callus size, the factor that caused the majority of the variation was genotype (22%). The medium that induced the longest shoot was ½MS0.3Z, while the medium that produced the highest number of nodes and the highest number of shoots was ½MS2Z. Genotypes ‘Blue Bayou’ and ‘Centra Blue’ produced an increased amount of callus over time, whereas the ‘unreleased selection’ genotype produced the least amount of callus. The genotype with the highest total plant fresh weight after 90 days was ‘Blue Bayou’ on WPM2Z medium in high light conditions.
DOI: 10.6084/m9.figshare.3504785.v1
title: Effect of genotype, medium and light on in vitro plant proliferation of <i>Vaccinium</i> spp.

description: The aim of this study was to investigate how growing conditions and media enhance blueberry proliferation. The effects of combinations of five <i>Vaccinium</i> spp. genotypes, two growing conditions and four proliferation media on plant growth were investigated. For shoot length and number of shoots, the factor responsible for the majority of the variance was the medium (13% and 22%, respectively). For callus size, the factor that caused the majority of the variation was genotype (22%). The medium that induced the longest shoot was ½MS0.3Z, while the medium that produced the highest number of nodes and the highest number of shoots was ½MS2Z. Genotypes ‘Blue Bayou’ and ‘Centra Blue’ produced an increased amount of callus over time, whereas the ‘unreleased selection’ genotype produced the least amount of callus. The genotype with the highest total plant fresh weight after 90 days was ‘Blue Bayou’ on WPM2Z medium in high light conditions.