cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.24412090.v1
title: Supplementary material for "The Relationship Between Cadmium Exposure and Preeclampsia: A systematic review and meta-analysis"

description: Background: Cadmium (Cd) is a heavy metal that has been associated with several disorders in humans. Preeclampsia is a major cause of maternal mortality worldwide. The association between maternal Cd exposure and preeclampsia remains elusive. Methods: To better understand this relationship, we conducted a systematic review and meta-analysis of eligible studies from five databases (PubMed, Embase, Web of Science, Scopus, and CNKI) from their inception to September 10, 2022. The quality of these studies was evaluated using the Newcastle-Ottawa quality assessment scale (NOS). We use random-effects models to calculate overall standardized mean differences (SMDs) and 95% confidence intervals (CIs). Sensitivity analyses were performed to assess the robustness of our results. We also evaluated publication bias using Egger’s and Begg’s tests. Additionally, we conducted meta-regression to identify potential sources of heterogeneity among studies. Results: Our analysis included a total of 17 studies with 10,373 participants. We found a significant association between maternal cadmium exposure and the risk of preeclampsia (SMD 0.27, 95% CI 0.09-0.44, p &lt; 0.01). No significant publication bias was detected in Begg’s or Egger’s tests. Meta-regression suggested that geographical location, year of publication, cadmium samples, sample size, and measurement methods did not contribute to heterogeneity between studies. Conclusion: Our findings suggest that maternal cadmium exposure is associated with an increased risk of preeclampsia. Further high-quality clinical studies and animal experiments are needed to understand this association better.
DOI: 10.57967/hf/1279
title: testsplat
DOI: 10.6084/m9.figshare.24433576
title: Data.zip

description: Metamorpheus data output imputted to IsoBayes model to perform single-isoform proteomics inference reported in the "IsoBayes: a Bayesian approach for single-isoform proteomics inference" paper.
DOI: 10.6084/m9.figshare.24433576.v1
title: Data.zip

description: Metamorpheus data output imputted to IsoBayes model to perform single-isoform proteomics inference reported in the "IsoBayes: a Bayesian approach for single-isoform proteomics inference" paper.
DOI: 10.5281/zenodo.10041904
title: AS PRÁTICAS PEDAGÓGICAS E A INCLUSÃO DO ALUNO AUTISTA

description: Este artigo apresenta resultados de uma pesquisa sobre as práticas pedagógicas do professor da rede pública de ensino, procurando observar se as mesmas contribuem para a inclusão do aluno autista dentro da sala de aula regular. A pesquisa qualitativa foi  de grande importância, bem como a pesquisa bibliográfica e de campo. A fundamentação teórica se baseou-se nos seguintes autores Orrú (2012), Figueira (2011) e Declaração de Salamanca (1994), que contribuíram para uma reflexão pedagógica, acerca da Educação Inclusiva, que é direito de todos. Com a hipótese inicial: As práticas pedagógicas usadas pelos professores, não são planejadas considerando as individualidades do aluno autista, desse mode. Conclui-se as metodologias adotadas em sala de aula, da escola campo, não são satisfatórias, uma vez que não houve planejamento especifico e diferenciado para a criança que apresenta o autismo. Sendo assim, a inclusão não foi efetivada.
DOI: 10.5281/zenodo.10041905
title: AS PRÁTICAS PEDAGÓGICAS E A INCLUSÃO DO ALUNO AUTISTA

description: Este artigo apresenta resultados de uma pesquisa sobre as práticas pedagógicas do professor da rede pública de ensino, procurando observar se as mesmas contribuem para a inclusão do aluno autista dentro da sala de aula regular. A pesquisa qualitativa foi  de grande importância, bem como a pesquisa bibliográfica e de campo. A fundamentação teórica se baseou-se nos seguintes autores Orrú (2012), Figueira (2011) e Declaração de Salamanca (1994), que contribuíram para uma reflexão pedagógica, acerca da Educação Inclusiva, que é direito de todos. Com a hipótese inicial: As práticas pedagógicas usadas pelos professores, não são planejadas considerando as individualidades do aluno autista, desse mode. Conclui-se as metodologias adotadas em sala de aula, da escola campo, não são satisfatórias, uma vez que não houve planejamento especifico e diferenciado para a criança que apresenta o autismo. Sendo assim, a inclusão não foi efetivada.
DOI: 10.5281/zenodo.10046825
title: Raw IMC images associated with De Lima et al. 2023, BioRxiv

description: This dataset contains the raw IMC images associated with the paper "Spatial mapping of rheumatoid arthritis synovial niches reveals specific macrophage networks associated with response to therapy" (De Lima et al. 2023, BioRxiv). The output files by CyTOF IMC were exported to one TIFF per channel. This dataset contains 40 directory files corresponding to 40 regions of interest (see ImageNb_PatientID.xlsx file for additional information). Each directory contains 46 TIFF images, including the 34 channels used in our study and 1 TIFF of the cell segmentation mask.
DOI: 10.5281/zenodo.10047547
title: Phase Diagram of Kob-Andersen-Type Binary Lennard-Jones Mixtures

description: This data repository contains data related to the paper Phase Diagram of Kob-Andersen-Type Binary Lennard-Jones Mixtures, Phys. Rev. Lett. 120, 165501 (2018), DOI: 10.1103/PhysRevLett.120.165501 by Ulf R. Pedersen, Thomas B. Schrøder, and Jeppe C. Dyre.
 
Abstract of the paper:
The binary Kob-Andersen (KA) Lennard-Jones mixture is the standard model for computational studies of viscous liquids
and the glass transition. For very long simulations, the viscous KA system crystallizes, however, by phase separating
into a pure A particle phase forming a fcc crystal. We present the thermodynamic phase diagram for KA-type mixtures
consisting of up to 50% small (B) particles showing, in particular, that the melting temperature of the standard KA
system at liquid density 1.2 is 1.028(3) in A particle Lennard-Jones units. At large B particle concentrations, the
system crystallizes into the CsCl crystal structure. The eutectic corresponding to the fcc and CsCl structures is cutoff
in a narrow interval of B particle concentrations around 26% at which the bipyramidal orthorhombic PuBr3 structure is
the thermodynamically stable phase. The melting temperature's variation with B particle concentration at two constant
pressures, as well as at the constant density 1.2, is estimated from simulations at pressure 10.19 using isomorph
theory. Our data demonstrate approximate identity between the melting temperature and the onset temperature below which
viscous dynamics appears. Finally, the nature of the solid-liquid interface is briefly discussed.
DOI: 10.5281/zenodo.10047546
title: Phase Diagram of Kob-Andersen-Type Binary Lennard-Jones Mixtures

description: This data repository contains data related to the paper Phase Diagram of Kob-Andersen-Type Binary Lennard-Jones Mixtures, Phys. Rev. Lett. 120, 165501 (2018), DOI: 10.1103/PhysRevLett.120.165501 by Ulf R. Pedersen, Thomas B. Schrøder, and Jeppe C. Dyre.
 
Abstract of the paper:
The binary Kob-Andersen (KA) Lennard-Jones mixture is the standard model for computational studies of viscous liquids
and the glass transition. For very long simulations, the viscous KA system crystallizes, however, by phase separating
into a pure A particle phase forming a fcc crystal. We present the thermodynamic phase diagram for KA-type mixtures
consisting of up to 50% small (B) particles showing, in particular, that the melting temperature of the standard KA
system at liquid density 1.2 is 1.028(3) in A particle Lennard-Jones units. At large B particle concentrations, the
system crystallizes into the CsCl crystal structure. The eutectic corresponding to the fcc and CsCl structures is cutoff
in a narrow interval of B particle concentrations around 26% at which the bipyramidal orthorhombic PuBr3 structure is
the thermodynamically stable phase. The melting temperature's variation with B particle concentration at two constant
pressures, as well as at the constant density 1.2, is estimated from simulations at pressure 10.19 using isomorph
theory. Our data demonstrate approximate identity between the melting temperature and the onset temperature below which
viscous dynamics appears. Finally, the nature of the solid-liquid interface is briefly discussed.
DOI: 10.5281/zenodo.10046182
title: Plastic Litter Project 2022-2023 - Minimum Detection Fraction Dataset

description: Sentinel-2 and PlanetScope SuperDove data, with corresponding UAS RGB reference images (where available) used in
DOI: 10.5281/zenodo.10046181
title: Plastic Litter Project 2022-2023 - Minimum Detection Fraction Dataset

description: Sentinel-2 and PlanetScope SuperDove data, with corresponding UAS RGB reference images (where available) used in
DOI: 10.5281/zenodo.10039282
title: test a part of input and output files of Li(FSA)(SN)2 classical MD
DOI: 10.5281/zenodo.10042370
title: MIELOENCAFALITE PROTOZOÁRIA EQUINA: RELATO DE CASO EM CAVALO MANGA-LARGA DA CIDADE DE SÃO GOTARDO, MG

description: A mieloencefalite protozoária equina (MEP) trata-se de uma enfermidade neurológica Sarcocystis neurona comumente conhecida como "bambeira", tal doença ocorre quando animal ingere alimentos contaminados pelas fezes do hospedeiro definitivo Didelphis sp e Didelphis albiventris, gambá. O diagnóstico pode ser realizado pela avaliação clínica de um médico veterinário habilitado ou através de um teste de alto custo nomeado Westen bloot, porém não é realizado no Brasil e é de alto custo. O tratamento é longo e caso seja detectado precocemente pode ter um prognóstico favorável, desde que use os medicamentos corretos e as terapias adequadas, se houver demora no tratamento, o animal pode sofrer sequelas. Este artigo tem como objetivo relatar um estudo de caso clínico de um equino nomeado Ícaro, que sofreu mieloencefalite protozoária equina, no Sítio Três Poderes, na cidade de São Gotardo-Minas Gerais. O método foi revisão bibliográfica narrativa, em forma de relato de caso. Os resultados foram positivos, pois o equino teve a saúde restaurada, apenas com uma leve sequela de atrofia muscular imperceptível aos leigos.
DOI: 10.5281/zenodo.10042371
title: MIELOENCAFALITE PROTOZOÁRIA EQUINA: RELATO DE CASO EM CAVALO MANGA-LARGA DA CIDADE DE SÃO GOTARDO, MG

description: A mieloencefalite protozoária equina (MEP) trata-se de uma enfermidade neurológica Sarcocystis neurona comumente conhecida como "bambeira", tal doença ocorre quando animal ingere alimentos contaminados pelas fezes do hospedeiro definitivo Didelphis sp e Didelphis albiventris, gambá. O diagnóstico pode ser realizado pela avaliação clínica de um médico veterinário habilitado ou através de um teste de alto custo nomeado Westen bloot, porém não é realizado no Brasil e é de alto custo. O tratamento é longo e caso seja detectado precocemente pode ter um prognóstico favorável, desde que use os medicamentos corretos e as terapias adequadas, se houver demora no tratamento, o animal pode sofrer sequelas. Este artigo tem como objetivo relatar um estudo de caso clínico de um equino nomeado Ícaro, que sofreu mieloencefalite protozoária equina, no Sítio Três Poderes, na cidade de São Gotardo-Minas Gerais. O método foi revisão bibliográfica narrativa, em forma de relato de caso. Os resultados foram positivos, pois o equino teve a saúde restaurada, apenas com uma leve sequela de atrofia muscular imperceptível aos leigos.
DOI: 10.5281/zenodo.10047575
title: From Lab to Technical CO2 Hydrogenation Catalysts: Understanding PdZn Decomposition

description: Supplementary material:  Additional experimental results, including catalytic performances of the different scaled-up samples, SEM images, and additional XAS data related to the linear combination fit
DOI: 10.5281/zenodo.10039281
title: test a part of input and output files of Li(FSA)(SN)2 classical MD
DOI: 10.5281/zenodo.10047576
title: From Lab to Technical CO2 Hydrogenation Catalysts: Understanding PdZn Decomposition

description: Supplementary material:  Additional experimental results, including catalytic performances of the different scaled-up samples, SEM images, and additional XAS data related to the linear combination fit
DOI: 10.25345/c5kw57v4p
title: MassIVE MSV000093209 - Suppression of eEF2 phosphorylation alleviates synaptic failure and cognitive deficits in mouse models of Down Syndrome
title: Down syndrome (DS) is the most common cause of intellectual disability. Cognitive impairment including dementia is a core feature of DS and the leading cause of dependence in people with DS. Currently there is no effective treatment for the cognitive deficits of DS, and the neurobiological mechanisms underlying DS-associated cognitive impairment remain unclear, hampering development of novel therapeutics. Maintenance of long-term synaptic plasticity and memory requires integral protein synthesis (mRNA translation) capacity. Recent studies indicate a role of translation dysregulation in multiple neurological disorders characterized by cognitive impairments including DS. Phosphorylation of the translational factor eukaryotic elongation factor 2 (eEF2) by its kinase eEF2K results in disruption of peptide growth and thus inhibition of de novo protein synthesis. Here we reported that eEF2K signaling was dysregulated in the brain of aged DS patients and two lines of DS mouse model. Inhibition of eEF2 phosphorylation through genetic suppression of eEF2K in two different DS model mice improved multiple aspects of DS-associated pathophysiology including de novo protein synthesis deficiency, synaptic morphological defects, long-term synaptic plasticity failure, and cognitive impairments. Proteomic analysis indicated that genetic suppression of eEF2K in the Dp16 DS model mice could promote protein synthesis-related pathways and synaptogenesis-related proteins. As a proof-of-concept study, treatment with small molecule eEF2K inhibitors ameliorated synaptic dysfunction and improved cognitive deficits in DS model mice. In summary, our data suggested that eEF2K signaling dysregulation may play a critical role in mediating DS-associated synaptic and cognitive impairments with aging. Future studies in more clinically relevant settings are warranted to determine whether targeting eEF2K signaling could be an effective therapeutic strategy for cognitive deficits in DS patients.
DOI: 10.6084/m9.figshare.24375790
title: Supplementary Material for: Diagnostic accuracy of urinary NT-proBNP for hemodynamically significant PDA in preterm infants

description: BACKGROUND: Echocardiography is the gold standard for the diagnosis hemodynamically significant-patent ductus arteriosus (hs-PDA). It requires trained personnel, and is not readily available. Urinary biomarkers can be used as an adjunct. OBJECTIVE: To systematically review the diagnostic accuracy of urinary NT-proBNP for hsPDA in preterm neonates. METHODS: We included studies that evaluated urinary NT-proBNP and urinary NT-proBNP/Creatinine ratio (index tests) in preterm neonates with hsPDA (participants) in comparison with echocardiogram (reference standard). Methodological quality and certainty of evidence were assessed using Quality Assessment of Diagnostic-Accuracy Studies (QUADAS-2) and Grading of Recommendations Assessment, Development and Evaluation (GRADE), respectively. RESULTS: Low quality of evidence suggests that Urinary NT-proBNP has modest sensitivity and specificity for the diagnosis of a hsPDA, with variation in accuracy based on assay and patient characteristics. CONCLUSION: Urinary NT-proBNP assays must be locally validated for specific patient populations and further studies to support its use must be performed.
DOI: 10.6084/m9.figshare.24375790.v1
title: Supplementary Material for: Diagnostic accuracy of urinary NT-proBNP for hemodynamically significant PDA in preterm infants

description: BACKGROUND: Echocardiography is the gold standard for the diagnosis hemodynamically significant-patent ductus arteriosus (hs-PDA). It requires trained personnel, and is not readily available. Urinary biomarkers can be used as an adjunct. OBJECTIVE: To systematically review the diagnostic accuracy of urinary NT-proBNP for hsPDA in preterm neonates. METHODS: We included studies that evaluated urinary NT-proBNP and urinary NT-proBNP/Creatinine ratio (index tests) in preterm neonates with hsPDA (participants) in comparison with echocardiogram (reference standard). Methodological quality and certainty of evidence were assessed using Quality Assessment of Diagnostic-Accuracy Studies (QUADAS-2) and Grading of Recommendations Assessment, Development and Evaluation (GRADE), respectively. RESULTS: Low quality of evidence suggests that Urinary NT-proBNP has modest sensitivity and specificity for the diagnosis of a hsPDA, with variation in accuracy based on assay and patient characteristics. CONCLUSION: Urinary NT-proBNP assays must be locally validated for specific patient populations and further studies to support its use must be performed.
DOI: 10.6084/m9.figshare.24218415
title: Supplementary Material for: Prediction of Food Sensitization in Children with Atopic Dermatitis Based on Disease Severity and Epidermal Layer Impairment

description: ABSTRACT Introduction: Atopic dermatitis (AD) is characterized by an impaired epidermal barrier, which could be associated with sensitization to food allergens (FA) and/or inhaled allergens and contribute to the severity of AD. However, no clinical guidance has been established for evaluations of food sensitization (FS) in AD patients. This study investigated how AD severity and epidermal barrier impairment are associated with FS, and factors that can predict FS in children with AD. Methods: This cross-sectional study included 100 children (12–60 months) diagnosed with AD. AD severity was determined using the Scoring Atopic Dermatitis (SCORAD) index. FS was evaluated by measuring serum specific IgE antibodies against 31 FAs using an immunoblotting method. Epidermal barrier impairment was assessed by measuring transepidermal water loss (TEWL) and stratum corneum hydration (SCH) levels. Results: 90% of participants were sensitized to at least one tested FA, with cow’s milk, egg white, beef, almond, egg yolk, and peanut being the most common. Children with moderate-severe AD had lower SCH levels than those with mild AD. Children with AD who were sensitized to &gt; 10 FAs had significantly higher TEWL and lower SCH levels, compared with those sensitized to 1–4 FAs and 5–10 FAs. The SCORAD score and SCH level in lesional skin provided moderately predictive value for sensitization to FAs in children with AD. Conclusion: FS is common in children with AD and closely associate with AD severity as well as epidermal barrier impairment. Evaluations of FS should be considered for children with moderate to severe AD and/or low SCH levels.
DOI: 10.6084/m9.figshare.24448723.v1
title: Non-canonical ORFs are an important source of neoantigens in patient tumors

description: The file contains the supplementary tables of the manuscript "Non-canonical ORFs are an important source of neoantigens in patient tumors" by Camarena ME. et al. It is in Microsoft Excel format and contains all data generated throughout the analysis, as well as a list of the publicly available datasets used in the publication.The first sheet contains a README with detailed information of what is shown in each of the other 23 sheets. It occupies ~ 90Mb.
DOI: 10.25625/ot6d7m/zka6yd
title: 2pmr_final.py

description: Python code for 2 particle microrheology
DOI: 10.25625/ot6d7m/990kqs
title: Main_Fig_2.7z

description: Data for figure 2 of the main text
DOI: 10.25625/ot6d7m/e0afk8
title: Main_Fig_3.7z

description: Data for figure 3 of the main text
DOI: 10.25625/ot6d7m/fnr8i5
title: Main_Fig_5.7z

description: Data for figure 5 of the main text
DOI: 10.25625/ot6d7m/x58ww9
title: Main_Fig_1.7z

description: Data for figure 1 in the main text
DOI: 10.25625/ot6d7m/bmnzcf
title: Sup_Fig_12.7z

description: Data for Supplementary Figure 12
DOI: 10.25625/ot6d7m/d2docj
title: Sup_Fig_5.7z

description: Data for Supplementary Figure 5
DOI: 10.25625/ot6d7m/ok9ezn
title: Main_Fig_4.7z

description: Data for figure 4 of the main text
DOI: 10.25625/ot6d7m/u7znjc
title: Sup_Fig_19.7z

description: Data for Supplementary Figure 19
DOI: 10.25625/ot6d7m/wxncxn
title: Sup_Fig_13.7z

description: Data for Supplementary Figure 13
DOI: 10.25625/ot6d7m/bt14ak
title: Sup_Fig_3.7z

description: Data for Supplementary Figure 3
DOI: 10.25625/ot6d7m/ej25ru
title: Sup_Fig_9.7z

description: Data for Supplementary Figure 9
DOI: 10.25625/ot6d7m/jnjs04
title: Sup_Fig_6.7z

description: Data for Supplementary Figure 6
DOI: 10.25625/ot6d7m/wj4uxw
title: Sup_Fig_17.7z

description: Data for Supplementary Figure 17
DOI: 10.25625/ot6d7m/zsou8u
title: Sup_Fig_1.7z

description: Data for Supplementary Figure 1
DOI: 10.25625/ot6d7m/0rnfab
title: Sup_Fig_15.7z

description: Data for Supplementary Figure 15
DOI: 10.25625/ot6d7m/nwpqob
title: Sup_Fig_18.7z

description: Data for Supplementary Figure 18
DOI: 10.25625/ot6d7m/qm9xoo
title: Sup_Fig_8.7z

description: Data for Supplementary Figure 8
DOI: 10.25625/ot6d7m/wtzikn
title: Sup_Fig_11.7z

description: Data for Supplementary Figure 11
DOI: 10.25625/ot6d7m/xogd8g
title: Sup_Fig_10.7z

description: Data for Supplementary Figure 10
DOI: 10.25625/ot6d7m/6ptb0b
title: Sup_Fig_4.7z

description: Data for Supplementary Figure 4
DOI: 10.25625/ot6d7m/dz35u6
title: Sup_Fig_14.7z

description: Data for Supplementary Figure 14
DOI: 10.25625/ot6d7m/eltzgr
title: Sup_Fig_16.7z

description: Data for Supplementary Figure 16
DOI: 10.25625/ot6d7m/lpwej7
title: ActinIsoforms_Code.7z

description: Matlab code for data analysis and microrheology
DOI: 10.25625/ot6d7m/wp1btr
title: Sup_Fig_7.7z

description: Data for Supplementary Figure 7
DOI: 10.25625/ot6d7m/zrpk7m
title: Sup_Fig_2.7z

description: Data for Supplementary Figure 2
DOI: 10.25625/ot6d7m
title: Replication Data for: Cytosolic actin isoforms form networks with different rheological properties that indicate specific biological function

description: Used datasets
DOI: 10.25625/ot6d7m/gdtoqy
title: Sup_Fig_2.7z

description: Data for Supplementary Figure 2
DOI: 10.25625/ot6d7m/u0zo58
title: Sup_Fig_1.7z

description: Data for Supplementary Figure 1
DOI: 10.6084/m9.figshare.24347359
title: Supplementary Material for: Tuberculosis case detection and guideline adherence among child contacts in Switzerland: a retrospective observational study.

description: Background: Children exposed to a tuberculosis (TB) index case are at high risk of TB infection and disease. The aim of this study was to describe the proportion of child contacts who developed TB infection or disease after exposure, to assess the diagnostic pathways and adherence to current guidelines. Method: Retrospective observational study including children ≤ 16 years of age who had contact to a TB index case between January 2019 and July 2021. Analysis was stratified by age groups 0 to 4, 5 to 11 and 12 to 16 years. Results: Of 401 TB-exposed children, data were available for 380 (95%). Of those, 7 (2%) were diagnosed with TB disease and 35 (8%) with TB infection. We identified several deviations in the procedures compared to Swiss guidelines: In the children aged 0 to 4 years, only 82% were examined with an immunodiagnostic test or a chest radiography within two weeks after last contact. Recommended prophylactic treatment was prescribed in 66% of the children only. In the children aged 5 to 11 years, 64% were tested with an immunodiagnostic test in a first examination and 75% in a second examination, two weeks and two months after last contact, respectively. Conclusions: Contact investigations of children exposed to a TB index case identified a significant proportion of children with TB infection and disease in a low TB incidence setting. We observed significant deviations from the guidelines in the contact investigations suggesting the need for improved implementation.