cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.7507823.v1
title: Teaching Bioethics: evaluation of a virtual learning object

description: Abstract The use of information and communication technologies brought together the teaching of bioethics and professional practice. The objective of the study is to evaluate the Virtual Learning Object ─ Analysis of Ethical Situations, developed and used as an innovative approach to the teaching of bioethics in courses in the field of health. The methodology integrates quantitative and qualitative analysis. Participants are students who used the virtual object in the disciplines of Ethics and Bioethics of Dentistry and Speech Therapy courses. A questionnaire (open and closed questions) was applied, and the categories analyzed related to the use of the virtual object and learning of bioethics: interaction, curriculum content, and teaching and learning dynamics. Testimonials show that the educational material provided analysis of situations with potential bioethical conflicts and demonstrated the possibility of practicing interdisciplinarity, considering this experience important in the training of health professionals. The study points to bioethics as a cross-curricular field of health practices.
DOI: 10.6084/m9.figshare.13227800.v3
title: Conversation in elderly people

description: [data.txt]<br>We recorded conversations of groups of four or five with 65 older Japanese people between June and September 2018. There were 16 groups and they were fixed over 14 sessions. In addition, as a condition, eight groups were required to speak freely and the remaining eight groups were required to make a presentation. Each session took place once a week for approximately 30 minutes. We decomposed the raw conversation into words and lemmatized the words. All words have been replaced with numbers to exclude personal information. The word column in the data represents words; the id column represents participants from 1 to 65; session represents session numbers from 1 to 14; group represents 16 groups from A to P; condition represents either free conversation or presentation; and the word column represents the number of participants. The words are arranged in the order of time.<br>[data_heaps.txt]<br>This file contains the number of unique words when the number of words increases. Token and type means the number of words and the number of unique words, respectively. This files was transformed from data.txt.<br>[cognitive_score.csv]This file contains cognitive scores and other characteristics for 65 participants.
DOI: 10.6084/m9.figshare.27477987.v1
title: The long-term persistence of <i>w</i>Mel strain in <i>Aedes aegypti</i> is threatened by multiple concomitant factors

description: Background <i>Wolbachia</i> symbionts introduced into <i>Aedes</i> <i>aegypti</i> provide an effective strategy to mitigate dengue virus transmission and has been increasingly utilized in endemic settings. Deployments in Rio finished in December 2019 with a suboptimal 32% introgression of <i>w</i>Mel strain, resulteing in 38% and 10% reduction of dengue and chikungunya, respectively.Methods We conducted a multidisciplinary independent evaluation of <i>w</i>Mel during 20 consecutive months starting August 2021 to evaluate whether its distribution would expand or retract. We used 75 BG-Sentinel traps distributed in 12 neighborhoods with estimated 500,000 inhabitants. We collected more than 50,000 mosquitoes and a subset of <i>Ae. aegypti</i><i> </i>were screened individually for <i>w</i>Mel presence. <i>Culex</i> spp., climate, environmental and insecticide application data was used to model the spatiotemporal introgression of <i>w</i>Mel.Findings The routine insecticide rotation adopted by the Brazilian Ministry of Health replaced the analogue of juvenile hormone (pyriproxyfen) by the bioinsecticide spinosad. This change in the larvicide crashed both <i>w</i>Mel-infected and -uninfected populations shortly after an increase in coverage with spinosad. However, the <i>w</i>Mel-uninfected mosquitoes recovered soon to levels even higher than before, whereas the <i>w</i>Mel-infected failed to recover after the population crash. The well documented fitness cost of <i>w</i>Mel<i> </i>in egg hatching leads to the absence of an egg bank necessary to recover after adult population was disrupted. Finally, we observed a <i>Wolbachia</i> loss of 24.56% in field-caught mosquitoes.Interpretation The reason underlying the poor introgression of <i>Wolbachia</i> <i>w</i>Mel strain is multifold. The adoption of an effective larvicide that crashed both <i>w</i>Mel-infected and -uninfected populations, the absence of an egg bank due to high fitness cost of egg hatching in the <i>w</i>Mel-infected mosquitoes, and a <i>Wolbachia</i> loss contribute to the lower invasion and, by corollary, modest epidemiological outcome in Rio de Janeiro. It becomes essential to implement technical guidance on Integrated Vector Management in Brazil prior the nationwide release of <i>Wolbachia</i>-infected mosquitoes in order to optimize dengue mitigation efforts while ensuring the judicious use of resources.
DOI: 10.4121/uuid:3ce7644e-dca5-46a5-801d-f6b4e416c4c7
title: Result of principal component analysis for Q-methodology of the study of the perceptions of justice regarding the carnivore conflict in Norway

description: Human-wildlife conflict is increasingly being recognised as containing strong elements of social conflict that can only be solved through understanding the perceptions and beliefs of the stakeholders involved. This dataset is supplementary to the paper that investigates the perceptions of justice regarding the carnivore conflict in Norway among sheep farmers, environmentalists and indigenous reindeer herders. Q methodological factor analysis revealed three distinct viewpoints perspectives on carnivores and the Norwegian carnivore policy.
DOI: 10.6084/m9.figshare.12336140.v1
title: Datasets of 'Response of male and female domestic chicks to change in the number (quantity) of imprinting objects '

description: Datasets of Response of male and female domestic chicks to change in the number (quantity) of imprinting objects
DOI: 10.6084/m9.figshare.23932899.v4
title: Biomass and Increment Statistics (Excel)

description: Harmonized statistics at national and sub-national level provide the forest biomass, FAWS and increment. They provide: the forest area (ha), the forest area available for wood supply (FAWS) (ha), the forest area not available for wood supply biomass (FNAWS) (ha), the forest aboveground biomass as AGB stock (t) and AGB/ha (t/ha), the forest aboveground biomass stock available for wood supply (BAWS) (t) and the forest aboveground biomass stock not available for wood supply (BNAWS) (t) for the year 2020; and the forest area (ha), the Forest area Available for Wood Supply (FAWS) (ha), and the Gross Annual Increment (GAI), the Annual Natural Losses (ANL), the Net Annual Increment (NAI) for the forest area and FAWS area for the period 2010 - 2020 (reference year: 2015) in units of volume per year (m<sup>3</sup>/year) and volume per hectare per year (m<sup>3</sup>/ha/year). NB: In this collection, the same statistics are also provided as spatial data in three Shapefile (“Biomass_Statistics.shp”, “FAWS_Statistics.shp”, “Increment_Statistics.shp”), which which provide the biomass, FAWS and increment for different administrative or NUTS units.
DOI: 10.6084/m9.figshare.7053533.v1
title: Supplementary Material for: Markers Involved in Innate Immunity and Neutrophil Activation are Elevated during Acute Human Anaphylaxis: Validation of a Microarray Study

description: <b><i>Background:</i></b> We have previously identified the upregulation of the innate immune response, neutrophil activation, and apoptosis during anaphylaxis using a microarray approach. This study aimed to validate the differential gene expression and investigate protein concentrations of “hub genes” and upstream regulators during anaphylaxis. <b><i>Methods:</i></b> Samples were collected from patients with anaphylaxis on their arrival at the emergency department, and after 1 and 3 h. mRNA levels of 11 genes (<i>interleukin-6 [IL-6], IL-10, oncostatin M [OSM], S100A8, S100A9, matrix metalloproteinase 9 [MMP9], FASL, toll-like receptor 4 [TLR4], MYD88, triggering receptor expressed on myeloid cells 1 [TREM1]</i>, and <i>cluster of differentiation 64 [CD64]</i>) were measured in peripheral blood leucocytes using qPCR. Serum protein concentrations were measured by ELISA or cytometric bead array for 6 of these candidates. <b><i>Results:</i></b> Of 69 anaphylaxis patients enrolled, 36 (52%) had severe reactions, and 38 (55%) were female. Increases in both mRNA and protein of IL-10, S100A9, MMP9, and TREM1 were observed. <i>OSM</i>, <i>S100A8</i>, <i>TLR4</i>, and <i>CD64</i> were upregulated and IL-6 protein concentrations were increased during anaphylaxis. Both <i>FASL</i> and soluble Fas ligand decreased during anaphylaxis. <b><i>Conclusion:</i></b> These results provide evidence for the involvement of innate immune pathways and myeloid cells during human anaphylaxis, validating previous microarray findings. Elevated <i>S100A8</i>, <i>S100A9</i>, <i>TLR4</i>, and <i>TREM1</i> expression, and increased S100A9 and soluble TREM1 protein concentrations strongly suggest that neutrophils are activated during acute anaphylaxis.
DOI: 10.6084/m9.figshare.12363587.v1
title: SonarQube 8.2 Java ruleset

description: Description of the SonarQube rules used in our study.
DOI: 10.6084/m9.figshare.14304238.v1
title: Perovskite-Type Oxides La0.6M0.4Ni0.6Cu0.4O3 (M = Ag, Ba, Ce) towards the Oxygen Reduction Reaction (ORR) in Alkaline Medium: Structural Aspects and Electrocatalytic Activity

description: In this work, La0.6M0.4Ni0.6Cu0.4O3 (M = Ag, Ba, and Ce, denoted as LANC, LBNC, and LCNC, respectively) electrocatalysts were synthesized by the Pechini method at 1023 K for two hours in air. Rietveld refinement allowed the identification of the crystallographic phases present in all oxides. The electrocatalytic performance of these oxides towards the oxygen reduction reaction (ORR) was examined in alkaline medium by rotating disk electrode (RDE) technique and scanning electrochemical microscopy (SECM) in the redox competition mode. The results indicate that the best performance was found with the LANC electrocatalyst prepared with carbon as a conducting agent (LANC/Carbon), which showed good catalytic activity towards the ORR via a pseudo four-electron transfer pathway. The enhanced electrocatalytic activity of LANC is probably a result of the presence of a Ag phase, which improves the synergistic effect between the perovskite and carbon added to increase the conductivity, thus leading to a higher ORR performance when compared to other materials.
DOI: 10.6084/m9.figshare.7581827.v1
title: manuscript data

description: manuscript data<br>
DOI: 10.6084/m9.figshare.26785991.v1
title: Additional file 1 of Evolutionary dependency of cancer mutations in gene pairs inferred by nonsynonymous-synonymous mutation ratios

description: Additional file 1: Table S1. Gene used for ED analyses. Table S2. PanCancer gene pairs with ED. Table S3. Tumor type-specific gene pairs with ED. Table S4. ED and genetic dependencies. Table S5. Effect size of targeted agents with ED of gene pairs
DOI: 10.6084/m9.figshare.19391441.v1
title: Supplementary Material for: Clinical Outcomes of Postoperative Adjuvant Chemotherapy for Surgically Resected High-Grade Pulmonary Neuroendocrine Carcinoma

description: Introduction: Data on the clinical outcomes of patients receiving adjuvant chemotherapy for surgically resected high-grade pulmonary neuroendocrine carcinoma (HGNEC) (large-cell neuroendocrine carcinoma and small-cell lung cancer) are limited. This study aimed to evaluate the prognostic significance of adjuvant chemotherapy in patients with HGNEC. Methods: We retrospectively analyzed patients with surgically resected HGNEC at five institutions in Japan between January 2006 and May 2016. Results: A total of 143 patients were enrolled. Among them, 65 received adjuvant chemotherapy. Four patients who participated in clinical trials were excluded; the remaining 61 patients were included in the study. Fifty-six patients received adjuvant small-cell lung cancer-based chemotherapy. Twenty-five of 29 patients who relapsed after postoperative adjuvant chemotherapy received chemotherapy. The most commonly administered chemotherapy agent was amrubicin. The 3-year relapse-free and overall survival rates were 55.2% and 66.8%, respectively. The median relapse-free and overall survival times for the 25 patients who received chemotherapy after relapse were 12.9 and 27.5 months, respectively. Among them, 22 relapsed within 2 years. Patients who received platinum-doublet chemotherapy after relapse tended to have better time to progression disease and overall survival than those who received single-agent chemotherapy. Conclusions: Most patients with HGNEC received small-cell lung cancer-based regimens as postoperative adjuvant chemotherapy. Those who relapsed after adjuvant chemotherapy were mainly treated with amrubicin. Our findings suggest that platinum-doublet chemotherapy tends to improve the time to progression disease and overall survival in patients who relapse after postoperative adjuvant chemotherapy.
DOI: 10.6084/m9.figshare.3580989.v4
title: Structural models of active and inactive structures of human High mobility group box 1 (HMGB1)

description: Structural models for the modelled HMGB1,HMGB1 without disulphide bond C23 and C45, HMGB1C23A, HMGB1C45A, HMGB1C106A, HMGB1SO3H.
DOI: 10.6084/m9.figshare.14798805.v1
title: Mixture Intensities

description: Intensity data for simulated mixture of beads measurements. The appended number is the angle.
DOI: 10.6084/m9.figshare.7477706.v1
title: Supplementary Material for: Shikimic Acid Inhibits Osteoclastogenesis in Vivo and in Vitro by Blocking RANK/TRAF6 Association and Suppressing NF-κB and MAPK Signaling Pathways

description: <b><i>Background/Aims:</i></b> Bone homeostasis is associated with the balance between bone-resorbing osteoclasts and bone-forming osteoblasts. Unbalanced bone homeostasis as a result of reduced osteogenesis or excessive osteoclastogenesis can lead to disorders such as osteoporosis, Paget’s disease, and rheumatoid arthritis. Shikimic acid is a cyclohexanecarboxylic acid, reported to exhibit pharmacological properties including anti-inflammatory and antioxidant activities. However, its effects on bone homeostasis remain unknown. <b><i>Methods:</i></b> First, the <i>in vitro</i> MTT cell viability assay was performed. Tartrate-resistant acid phosphatase (TRAP) and actin ring formation assays, as well as immunofluorescence staining were then performed to evaluate osteoclastogenesis. Potential signaling pathways were characterized by western blotting and verified in overexpression experiments. Related factors were examined by western blotting, reverse transcription polymerase chain reaction, electrophoretic mobility shift assay, and co-immunoprecipitation. Ovariectomized mice were used for the <i>in vivo</i> study. <b><i>Results:</i></b> TRAP staining showed that shikimic acid significantly inhibited osteoclastogenesis and pit resorption in bone marrow monocytes and RAW264.7 cells, and actin ring formation assays showed that shikimic acid suppressed the bone resorption function of osteoclasts. Furthermore, shikimic acid inhibited the receptor activator of nuclear factor-κB RANK/tumor necrosis factor receptor-associated factor 6 (TRAF6) association, suppressed nuclear factor-κB and mitogen-activated protein kinase signaling pathways, and downregulated nuclear factor of activated T-cell cytoplasmic 1. The expression of osteoclastogenesis biomarkers, including TRAF6, calcitonin receptor, TRAP, cathepsin K, and matrix metalloproteinase-9, was inhibited. <i>In vivo,</i> shikimic acid also significantly ameliorated bone loss and prevented osteoclastogenesis in ovariectomized mice. <b><i>Conclusion:</i></b> Shikimic acid inhibited osteoclastogenesis and osteoclast function by blocking RANK ligand-induced recruitment of TRAF6, as well as downstream signaling pathways <i>in vitro</i>. Shikimic acid also reduced ovariectomy-induced osteoclastogenesis and bone loss <i>in vivo</i>.
DOI: 10.6084/m9.figshare.22818173.v1
title: RAW data of the COP displacement and the power of EEG

description: Humans continuously maintain and adjust posture during gait, standing, and sitting. This data set includes the dataset of the COP displacement and the power of EEG obtained from 15 healthy young adults.
DOI: 10.6084/m9.figshare.26196017.v1
title: Supplementary Material for: Molecular characterization of enteric viruses causing acute gastroenteritis among children under 5 years old in Distrito Central, Honduras

description: Introduction: Diarrheal diseases constitute a significant public health problem in terms of mortality and morbidity. In Honduras and around the world, RVs have consistently emerged as the single most important etiologic agent in acute childhood diarrhea. However, other viruses, such as NoVs and HAstVs, have also been shown to be responsible for viral gastroenteritis. Unfortunately, the country has limited information concerning the etiologic role of these viral agents in acute gastroenteritis. This study investigated the frequency, genotypes, and epidemiological characteristics of RV-A, NoVs, and HAstVs among children under 5 years old in Distrito Central, Honduras. Methods: Stool samples and their corresponding epidemiological data were collected from children with acute gastroenteritis in three healthcare centers in Distrito Central. All samples were screened by immunoassays for RV-A and HAstVs. RV-A-positive samples were molecularly characterized by RT-PCR and genotyping assays. RT-PCR was also applied to confirm HAstVs positivity and to detect NoVs, followed by nucleotide sequencing to assign their genotypes. Results: Our results show that at least one viral agent was detected in 31% of the children. The frequency of RV-A, NoVs, and HAstVs was 14%, 13%, and 5%, respectively. The most frequent RV-A genotype was G2P[4], occurring in 93% of cases. 92.3% of NoVs-positive samples belonged to genogroup II, with GII.4 and GII.16 being the most common. HAstVs were clustered into three genotypes: HAstV-1, HAstV-2, and HAstV-8. Only one sample showed co-infection with NoVs and HAstVs. Conclusion: This comprehensive molecular and epidemiological characterization of enteric viruses demonstrates the vast diversity of these agents and describes for the first time NoVs and HAstVs as causative agents of acute childhood gastroenteritis in Distrito Central, Honduras. This suggests that further in-depth studies of the pediatric population are necessary to develop and implement effective preventive and control measures in the country.
DOI: 10.17608/k6.auckland.4557337.v1
title: SCoA-II Data Files

description: The SPSS and AMOS data files containing all data information collected from the SCoA-II questionnaire administered in 2004. <br>The SPSS data file containing the data information collected from the SCoA-II questionnaire administered in 2004. <br><br>The AMOS data file is the confirmatory factor analysis input for the SCoA-II data set. <br><br>Results were published in:<br>Brown, G. T. L., & Hirschfeld, G. H. F. (2008). Students’ conceptions of assessment: Links to outcomes. <i>Assessment in Education: Principles, Policy and Practice, 15</i>(1), 3-17<i>. </i>doi:10.1080/09695940701876003<br>Hirschfeld, G. H. F., & Brown, G. T. L. (2009). Students’ conceptions of assessment: Factorial and structural invariance of the SCoA across sex, age, and ethnicity. <i>European Journal of Psychological Assessment, 25</i>(1), 30-38. doi:10.1027/1015-5759.25.1.30<br>Walton, K. F. (2009). <i>Secondary students’ conceptions of assessment mediated by self-motivational attitudes: Effects on academic performance.</i> (Unpublished M.Ed. thesis), University of Auckland, Auckland, NZ.
DOI: 10.6084/m9.figshare.5319037.v1
title: EEMs.zip

description: Contains excitation-emission matrices for all samples and a MQ blank.
DOI: 10.6084/m9.figshare.13514801.v1
title: P3-PB

description: Processed 10X scRNA-seq data of PB from P3 patient.
DOI: 10.6084/m9.figshare.26488519.v1
title: <b>Code Today, Deadline Tomorrow: Procrastination Among Software Developers</b>

description: This is the supplementary material of the paper "Code Today, Deadline Tomorrow: Procrastination Among Software Developers".
DOI: 10.6084/m9.figshare.15228690.v1
title: CO2 sequestration fractions

description: This dataset provides output from the CO2 sequestration calculations presented in the following paper: Siegel, D. A., DeVries, T., Doney, S., & Bell, T. (2021). Assessing the sequestration time scales of some ocean-based carbon dioxide reduction strategies. <i>Environmental Research Letters</i>.<br>This dataset provides the fraction of injected CO2 retained in the ocean for 0-1000 years after injection, which is referred to as f(t) in the above referenced paper. This fraction is shown in Figure 2 and Figure 4 of the above referenced paper, which can be reproduced using this dataset. This dataset only covers the years 0-1000 years, while the results shown in the above referenced paper are based on simulations running up to 5000 years after injection. For the longer simulations, or other output from the model, please contact the author.<br><br>A Matlab script with some example calculations is also provided. This script loads in the dataset and plots the fraction sequestered after 100 years for CO2 injection near the seafloor, and also plots f(t) from 0-1000 years for a user-specified location.<br>If using this dataset, please cite the original publication of Siegel et al. (2021).<br>
DOI: 10.6084/m9.figshare.19252364.v2
title: Supplemental Table S1 for Pathogenic copy number and sequence variants in children born SGA with short stature without imprinting disorders

description: Supplemental Table showing the list of genes relate to growth failure and/or skeletal dysplasia described in the current paper by Hara-Isono K.
DOI: 10.6084/m9.figshare.21208643.v1
title: CNN Master Data

description: Master dataset for convolutional neural network (CNN). Consists of images of dive profiles for leatherback sea turtles (see Barbour et al for further description).
DOI: 10.60893/figshare.apl.28559261.v1
title: Supplement Number 1

description: See the supplementary material for calculation details, band gap variation, lattice symmetry operation and partly vibration mode
DOI: 10.6084/m9.figshare.1270464.v1
title: EXTRAVASACIÓN DE QUIMIOTERAPIA VESICANTE, CURA EN AMBIENTE HÚMEDO

description: En la extravasación de un vía venosa periférica parte del líquido infundido sale de la vena y se distribuye por los tejidos. Este hecho que no tiene importancia clínica en la mayoría de los casos se hace especialmente relevante cuando se trata de quimioterapia y más aún si ésta es vesicante. En este caso el fármaco extravasado produce necrosis de los tejidos y aunque se apliquen los antídotos pertinentes pueden producirse úlceras. La variabilidad de las lesiones depende del tipo de fármaco ya que se distribuyen en dos grupos en función del antídoto que precisen. Por otra parte la incidencia de extravasación de citostáticos en total es baja (entre el 0,01-7%) siendo la incidencia de extravasación de vesicantes aún menor. El objetivo de este trabajo es describir un caso y así poder establecer pautas de cura eficaces para un grupo de heridas muy especiales, con una baja incidencia pero con un curso muy agresivo. Para ello hemos hecho el seguimiento de un paciente que acude al hospital 9 días después del tratamiento de quimioterapia con una lesión en el antebrazo izquierdo sugestiva de extravasación tardía de un fármaco vesicante. Tras dos semanas de tratamiento con un total de 7 valoraciones presenciales de la lesión y 4 curas en ambiente húmedo (Hidrogel y espuma de poliuretano) la lesión cicatriza completamente. Por lo tanto, en este caso, la preparación del lecho de la herida y la cura en ambiente húmedo fue suficiente para conseguir la cicatrización completa de la lesión.