cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.21393468
title: The reliability and agreement of scores in a novel balance measure for older adults: Specific Training According to BaLance Evaluation (STABLE)

description: Falls are the leading cause of injury and premature death among community dwelling elderly but can be prevented through comprehensive balance rehabilitation which ideally targets the patient’s specific needs. In this study, we evaluate the reliability and agreement of six novel clinical measures of different balance domains which applied in a patient-specific balance profile guides exercise prescription in balance rehabilitation. The intra-rater reliability and agreement of the six measures were evaluated on the same day in six different cohorts of elderly with balance disability (<i>n</i> = 65–100). Further, the inter-day intra-rater and inter-rater and test–retest reliability and agreement of the measures and the balance profile were evaluated (<i>n</i> = 100). The intra-day intra-rater reliability and agreement was moderate to excellent (ICC<sub>2.1</sub> = 0.525–0.968, with SDC% = 6.5–284.9%) but poor to good for the inter-day conditions (ICC<sub>2.1</sub> = 0.123–0.832, with SDC% = 6.6–229.2%). The reliability of classifying the lower domain in the balance profile was fair, with kappa = 0.56 (95%CI 0.36–0.76). Five of the six measures may reliably be applied to measure balance disability and to guide rehabilitation. Implications for rehabilitationBalance disability is the primary reason for accidental falls among elderly but can be prevented through comprehensive individualized balance rehabilitation.Specific Training According to BaLance Evaluation (STABLE) is a novel approach for designing effective balance exercises based on clinical measurements.Five of the six measures are reliable when applied in a patient-specific balance profile to guide rehabilitation following the STABLE approach. Balance disability is the primary reason for accidental falls among elderly but can be prevented through comprehensive individualized balance rehabilitation. Specific Training According to BaLance Evaluation (STABLE) is a novel approach for designing effective balance exercises based on clinical measurements. Five of the six measures are reliable when applied in a patient-specific balance profile to guide rehabilitation following the STABLE approach.
DOI: 10.6084/m9.figshare.21393468.v1
title: The reliability and agreement of scores in a novel balance measure for older adults: Specific Training According to BaLance Evaluation (STABLE)

description: Falls are the leading cause of injury and premature death among community dwelling elderly but can be prevented through comprehensive balance rehabilitation which ideally targets the patient’s specific needs. In this study, we evaluate the reliability and agreement of six novel clinical measures of different balance domains which applied in a patient-specific balance profile guides exercise prescription in balance rehabilitation. The intra-rater reliability and agreement of the six measures were evaluated on the same day in six different cohorts of elderly with balance disability (<i>n</i> = 65–100). Further, the inter-day intra-rater and inter-rater and test–retest reliability and agreement of the measures and the balance profile were evaluated (<i>n</i> = 100). The intra-day intra-rater reliability and agreement was moderate to excellent (ICC<sub>2.1</sub> = 0.525–0.968, with SDC% = 6.5–284.9%) but poor to good for the inter-day conditions (ICC<sub>2.1</sub> = 0.123–0.832, with SDC% = 6.6–229.2%). The reliability of classifying the lower domain in the balance profile was fair, with kappa = 0.56 (95%CI 0.36–0.76). Five of the six measures may reliably be applied to measure balance disability and to guide rehabilitation. Implications for rehabilitationBalance disability is the primary reason for accidental falls among elderly but can be prevented through comprehensive individualized balance rehabilitation.Specific Training According to BaLance Evaluation (STABLE) is a novel approach for designing effective balance exercises based on clinical measurements.Five of the six measures are reliable when applied in a patient-specific balance profile to guide rehabilitation following the STABLE approach. Balance disability is the primary reason for accidental falls among elderly but can be prevented through comprehensive individualized balance rehabilitation. Specific Training According to BaLance Evaluation (STABLE) is a novel approach for designing effective balance exercises based on clinical measurements. Five of the six measures are reliable when applied in a patient-specific balance profile to guide rehabilitation following the STABLE approach.
DOI: 10.57841/casdc.0002769
title: 太阳能吸热集热系统温度测试
DOI: 10.34760/6526639ec9ed7
title: EpCAM lung
DOI: 10.57841/casdc.0002770
title: 跨季节储热体综合热损测试
DOI: 10.17632/s9hzb87x48.1
title: Camino and Dutta et al

description: raw data from images in the linked article
DOI: 10.57841/casdc.0002771
title: 集热系统效率测试
DOI: 10.34760/65266407cb945
title: eQTL Lung Consortium
DOI: 10.5281/zenodo.8430221
title: Data of : Assessment of CLEC4M and GSH in Iraqi Newly Diagnosed Cervical Cancer Women: A Case Control Study

description: Data of : Assessment of CLEC4M and GSH in Iraqi Newly Diagnosed Cervical Cancer Women: A Case Control Study
DOI: 10.5281/zenodo.8430220
title: Data of : Assessment of CLEC4M and GSH in Iraqi Newly Diagnosed Cervical Cancer Women: A Case Control Study

description: Data of : Assessment of CLEC4M and GSH in Iraqi Newly Diagnosed Cervical Cancer Women: A Case Control Study
DOI: 10.34760/6526645b80fc4
title: European Renal Association COVID-19 Database
DOI: 10.57841/casdc.0002772
title: 子课题发表的标准数据集
DOI: 10.5281/zenodo.8429929
title: Developing and testing protocols for fouling treatments on oysters

description: Aim: Develop protocols for effective fouling treatment on oysters (Ostrea edulis and Magallana gigas) in the lab. Fouling treatments were evaluated using lab trials (in tanks) for evaluation of effects of heat treatment of fouling organisms on oysters. A range of different temperatures and exposure times was evaluated. The data consists of parameters associated with the treatments (temperature) and survival of oysters, survival of fouling organisms. Data originates from the Swedish west coast.
DOI: 10.5281/zenodo.8429930
title: Developing and testing protocols for fouling treatments on oysters

description: Aim: Develop protocols for effective fouling treatment on oysters (Ostrea edulis and Magallana gigas) in the lab. Fouling treatments were evaluated using lab trials (in tanks) for evaluation of effects of heat treatment of fouling organisms on oysters. A range of different temperatures and exposure times was evaluated. The data consists of parameters associated with the treatments (temperature) and survival of oysters, survival of fouling organisms. Data originates from the Swedish west coast.
DOI: 10.57841/casdc.0002773
title: 反应等离子沉积制备镀铜硅异质结太阳能电池的IWO和ICO透明导电氧化膜的比较研究
DOI: 10.7488/ds/7519
title: Generation Scotland GWAS Summary Statistics for GDF15

description: The Generation Scotland: Scottish Family Health Study (GS:SFHS) is a family-based population cohort with DNA, biological samples, socio-demographic, psychological and clinical data from ~24,000 adult volunteers across Scotland. Although data collection was cross-sectional, GS:SFHS became a prospective cohort due to the ability to link to routine Electronic Health Record (EHR) data. Over 20,000 participants were selected for genotyping using a genome-wide array. Genome-wide association studies (GWAS) were used to test the effects of a spectrum of variants, imputed using the Haplotype Research Consortium (HRC) dataset allowed investigation of variants with low minor allele frequencies in the entire GS:SFHS genotyped cohort. Genome-wide associations were run on 20,032 individuals using both genotyped and HRC imputed data. The dataset contains genome-wide association summary statistics for this project. GWAS summary statistics of GDF15 in the Generation Scotland cohort. Data generated contributed to a paper submitted to Nature, "Fetally-encoded GDF15 and maternal GDF15 sensitivity are major determinants of nausea and vomiting in human pregnancy".
description: This dataset consists of summary statistics of the analysis of a genome-wide association study (GWAS) of serum GDF15 in Generation Scotland using HRC.r1-1*imputed genotypes and run with BOLT_lmm_2.2** "SNP","CHR","BP","GENPOS","ALLELE1","ALLELE0","A1FREQ","INFO","BETA","SE","P_BOLT_LMM" Summary stat column descriptions SNP- Position of the SNP in chromosome:position format ALLELE1 - allele for which results are reported ALLELE0 - other allele A1FREQ - Allele1 average frequency INFO - imputation quality - BETA - association effect size SE - standard error of the effect size P_BOLT_LMM - association p-value. *Haplotype Reference Consortium, http://www.haplotype-reference-consortium.org/ **Efficient Bayesian mixed-model analysis increases association power in large cohorts. Loh PR, Tucker G, Bulik-Sullivan BK, Vilhjálmsson BJ, Finucane HK, Salem RM, Chasman DI, Ridker PM, Neale BM, Berger B, Patterson N, Price AL. Nat Genet. 2015 Mar;47(3):284-90. doi: 10.1038/ng.3190. Epub 2015 Feb 2. PMID: 25642633
DOI: 10.34760/652664b071085
title: Fontan Attrition: Impact on the patients and Rate of deterioration
DOI: 10.5281/zenodo.8430217
title: Custom scripts used in microbiota analysis

description: Custom scripts used in microbiota analysis
DOI: 10.5281/zenodo.8430216
title: Custom scripts used in microbiota analysis

description: Custom scripts used in microbiota analysis
DOI: 10.24414/nc7j-b391
title: USET synoptic images/L1centered

description: The USET station also hosts since 2002 three modern telescopes equipped with digital cameras recording full-disk images of the Sun in three different parts of the visible-light spectrum: broad-band white-light to observer the photosphere, and two telescopes with narrow-band filters (H-alpha line at 656.3 nm and Ca II K line at 393.37 nm) to monitor the chromosphere, where solar eruptive phenomena can be detected. The images have been recentered (less than 1 pixel precision), information about coordinate system was added in the header, so that data can be further processed with existing solar libraries and softwares. The image file format is FITS. The FITS header has been made homogeneous throughout the dataset and complies with the SOLARNET recommendations.
DOI: 10.34760/6526650ca9379
title: Gastrointestinal stromal tumors
DOI: 10.6084/m9.figshare.24100152
title: <b>TOP2A promotes proliferation and metastasis of esophageal squamous cell carcinoma via activation of the p53 signaling pathway.</b>

description: TOP2A在食管鳞状细胞癌（ESCC）组织中高表达，与TE-109和TE-2细胞相比，Eca1细胞表现出最高的TOP13A表达。敲低TOP2A上调p53并削弱体内Eca109细胞的致瘤性。此外，TEM在对照组中显示出更多的自噬溶酶体和自噬体。生物信息学分析显示，TOP2A通过p53信号通路发挥其作用。重要的是，TOP2A对ESCC细胞增殖和迁移的影响被Pifithrin-α逆转。
DOI: 10.6084/m9.figshare.24100152.v1
title: <b>TOP2A promotes proliferation and metastasis of esophageal squamous cell carcinoma via activation of the p53 signaling pathway.</b>

description: TOP2A在食管鳞状细胞癌（ESCC）组织中高表达，与TE-109和TE-2细胞相比，Eca1细胞表现出最高的TOP13A表达。敲低TOP2A上调p53并削弱体内Eca109细胞的致瘤性。此外，TEM在对照组中显示出更多的自噬溶酶体和自噬体。生物信息学分析显示，TOP2A通过p53信号通路发挥其作用。重要的是，TOP2A对ESCC细胞增殖和迁移的影响被Pifithrin-α逆转。
DOI: 10.57841/casdc.0002774
title: 多位点离子液体催化剂的性能评价数据说明
DOI: 10.57841/casdc.0002775
title: CO2羰基化连续放大装置运行数据说明
DOI: 10.57841/casdc.0002776
title: 10万吨/年碳酸二甲酯联产乙二醇工业装置运行数据说明
DOI: 10.6084/m9.figshare.24288679
title: Supplementary Material for: Targeting cartilage miR-195/497 cluster for osteoarthritis treatment regulates the circadian clock

description: Introduction: Osteoarthritis (OA) is the most prevalent and debilitating joint disease without an effective therapeutic option. Multiple risk factors for OA have been identified, including abnormal chondrocyte miRNA secretion and circadian rhythms disruption, both of which have been found to cause progressive damage and loss of articular cartilage. Environmental disruption of circadian rhythms in mice predisposes animals to cartilage injury and OA. Methods: The role of miR-195/497 cluster during OA progression was verified by mouse OA model with intraarticular injection of Agomir and Antagomir. We performed micro-CT analysis, Osteoarthritis Research Society International scores, and histological analysis in mouse knee joints. RNA sequencing was performed on the mouse cartilage cell line to explore the molecular mechanism of the miR-195/497 cluster and proteins in signaling pathway were evaluated using western blot. Senescence associated phenotypes were detected by western blot, senescence β-galactosidase Staining, and immunofluorescence. Results: This study demonstrated that miR-195/497-5p expression is disrupted in OA with senescent chondrocytes. In addition, miR-195/497-5p influenced the circadian rhythm of mice chondrocytes by modulating the expression of the Per2 protein, resulting in the gradual degradation of articular cartilage. We found that the miR-195/497 cluster targets DUSP3 expression. The deletion of the miR-195/497 cluster increased the level of DUSP3 expression and decreased the levels of phosphorylated ERK 1/2 and CREB. Per2 transcription is up-regulated by stimulating CREB and ERK1/2 phosphorylation. Conclusion: Our findings identify a regulatory mechanism connecting chondrocyte miR-195/497-5p to cartilage maintenance and repair and imply that circadian rhythm disturbances affected by miR-195/497-5p are risk factors for age-related joint diseases such as OA
DOI: 10.34760/65266583ddcd7
title: GeneticLines biobank
DOI: 10.57841/casdc.0002777
title: 醇解反应精馏连续放大装置运行数据说明
DOI: 10.5281/zenodo.8430248
title: Evaluating Accuracy Improvements of Large Language Models Using Retrieval Augmented Generation

description: Original data
DOI: 10.5281/zenodo.8430247
title: Evaluating Accuracy Improvements of Large Language Models Using Retrieval Augmented Generation

description: Original data
DOI: 10.6084/m9.figshare.24288682
title: Supplementary Material for: Targeting cartilage miR-195/497 cluster for osteoarthritis treatment regulates the circadian clock

description: Introduction: Osteoarthritis (OA) is the most prevalent and debilitating joint disease without an effective therapeutic option. Multiple risk factors for OA have been identified, including abnormal chondrocyte miRNA secretion and circadian rhythms disruption, both of which have been found to cause progressive damage and loss of articular cartilage. Environmental disruption of circadian rhythms in mice predisposes animals to cartilage injury and OA. Methods: The role of miR-195/497 cluster during OA progression was verified by mouse OA model with intraarticular injection of Agomir and Antagomir. We performed micro-CT analysis, Osteoarthritis Research Society International scores, and histological analysis in mouse knee joints. RNA sequencing was performed on the mouse cartilage cell line to explore the molecular mechanism of the miR-195/497 cluster and proteins in signaling pathway were evaluated using western blot. Senescence associated phenotypes were detected by western blot, senescence β-galactosidase Staining, and immunofluorescence. Results: This study demonstrated that miR-195/497-5p expression is disrupted in OA with senescent chondrocytes. In addition, miR-195/497-5p influenced the circadian rhythm of mice chondrocytes by modulating the expression of the Per2 protein, resulting in the gradual degradation of articular cartilage. We found that the miR-195/497 cluster targets DUSP3 expression. The deletion of the miR-195/497 cluster increased the level of DUSP3 expression and decreased the levels of phosphorylated ERK 1/2 and CREB. Per2 transcription is up-regulated by stimulating CREB and ERK1/2 phosphorylation. Conclusion: Our findings identify a regulatory mechanism connecting chondrocyte miR-195/497-5p to cartilage maintenance and repair and imply that circadian rhythm disturbances affected by miR-195/497-5p are risk factors for age-related joint diseases such as OA
DOI: 10.6084/m9.figshare.24288682.v1
title: Supplementary Material for: Targeting cartilage miR-195/497 cluster for osteoarthritis treatment regulates the circadian clock

description: Introduction: Osteoarthritis (OA) is the most prevalent and debilitating joint disease without an effective therapeutic option. Multiple risk factors for OA have been identified, including abnormal chondrocyte miRNA secretion and circadian rhythms disruption, both of which have been found to cause progressive damage and loss of articular cartilage. Environmental disruption of circadian rhythms in mice predisposes animals to cartilage injury and OA. Methods: The role of miR-195/497 cluster during OA progression was verified by mouse OA model with intraarticular injection of Agomir and Antagomir. We performed micro-CT analysis, Osteoarthritis Research Society International scores, and histological analysis in mouse knee joints. RNA sequencing was performed on the mouse cartilage cell line to explore the molecular mechanism of the miR-195/497 cluster and proteins in signaling pathway were evaluated using western blot. Senescence associated phenotypes were detected by western blot, senescence β-galactosidase Staining, and immunofluorescence. Results: This study demonstrated that miR-195/497-5p expression is disrupted in OA with senescent chondrocytes. In addition, miR-195/497-5p influenced the circadian rhythm of mice chondrocytes by modulating the expression of the Per2 protein, resulting in the gradual degradation of articular cartilage. We found that the miR-195/497 cluster targets DUSP3 expression. The deletion of the miR-195/497 cluster increased the level of DUSP3 expression and decreased the levels of phosphorylated ERK 1/2 and CREB. Per2 transcription is up-regulated by stimulating CREB and ERK1/2 phosphorylation. Conclusion: Our findings identify a regulatory mechanism connecting chondrocyte miR-195/497-5p to cartilage maintenance and repair and imply that circadian rhythm disturbances affected by miR-195/497-5p are risk factors for age-related joint diseases such as OA
DOI: 10.6084/m9.figshare.24288688
title: Supplementary information from The genome of the deep-sea anemone <i>Actinernus</i> sp. contains a mega-array of ANTP-class homeobox genes

description: Members of the phylum Cnidaria include sea anemones, corals and jellyfish, and have successfully colonized both marine and freshwater habitats throughout the world. The understanding of how cnidarians adapt to extreme environments such as the dark, high-pressure deep-sea habitat has been hindered by the lack of genomic information. Here, we report the first chromosome-level deep-sea cnidarian genome, of the anemone <i>Actinernus</i> sp., which was 1.39 Gbp in length and contained 44 970 gene models including 14 806 tRNA genes and 30 164 protein-coding genes. Analyses of homeobox genes revealed the longest chromosome hosts a mega-array of Hox cluster, HoxL, NK cluster and NKL homeobox genes; until now, such an array has only been hypothesized to have existed in ancient ancestral genomes. In addition to this striking arrangement of homeobox genes, analyses of microRNAs revealed cnidarian-specific complements that are distinctive for nested clades of these animals, presumably reflecting the progressive evolution of the gene regulatory networks in which they are embedded. Also, compared to other sea anemones, circadian rhythm genes were lost in <i>Actinernus</i> sp., which likely reflects adaptation to living in the dark. This high-quality genome of a deep-sea cnidarian thus reveals some of the likely molecular adaptations of this ecologically important group of metazoans to the extreme deep-sea environment. It also deepens our understanding of the evolution of genome content and organization of animals in general and cnidarians in particular, specifically from the viewpoint of key developmental control genes like the homeobox-encoding genes where we find an array of genes that until now has only been hypothesized to have existed in the ancient ancestor that pre-dated both the cnidarians and bilaterians.
DOI: 10.6084/m9.figshare.24288688.v1
title: Supplementary information from The genome of the deep-sea anemone <i>Actinernus</i> sp. contains a mega-array of ANTP-class homeobox genes

description: Members of the phylum Cnidaria include sea anemones, corals and jellyfish, and have successfully colonized both marine and freshwater habitats throughout the world. The understanding of how cnidarians adapt to extreme environments such as the dark, high-pressure deep-sea habitat has been hindered by the lack of genomic information. Here, we report the first chromosome-level deep-sea cnidarian genome, of the anemone <i>Actinernus</i> sp., which was 1.39 Gbp in length and contained 44 970 gene models including 14 806 tRNA genes and 30 164 protein-coding genes. Analyses of homeobox genes revealed the longest chromosome hosts a mega-array of Hox cluster, HoxL, NK cluster and NKL homeobox genes; until now, such an array has only been hypothesized to have existed in ancient ancestral genomes. In addition to this striking arrangement of homeobox genes, analyses of microRNAs revealed cnidarian-specific complements that are distinctive for nested clades of these animals, presumably reflecting the progressive evolution of the gene regulatory networks in which they are embedded. Also, compared to other sea anemones, circadian rhythm genes were lost in <i>Actinernus</i> sp., which likely reflects adaptation to living in the dark. This high-quality genome of a deep-sea cnidarian thus reveals some of the likely molecular adaptations of this ecologically important group of metazoans to the extreme deep-sea environment. It also deepens our understanding of the evolution of genome content and organization of animals in general and cnidarians in particular, specifically from the viewpoint of key developmental control genes like the homeobox-encoding genes where we find an array of genes that until now has only been hypothesized to have existed in the ancient ancestor that pre-dated both the cnidarians and bilaterians.
DOI: 10.34760/652665fe8608e
title: Groeicurves voor kinderen met CHARGE syndroom: een retrospectief cohortonderzoek
DOI: 10.34760/65266663a1ea2
title: Groningen and Leiden Universities study of Corticosteroids in Obstructive Lung Disease
DOI: 10.57841/casdc.0002778
title: 煤制乙二醇千吨装置技改数据集
DOI: 10.5519/qd.fzuf420c
title: Query on the Natural History Museum Data Portal (data.nhm.ac.uk) (2 records)
DOI: 10.6084/m9.figshare.24265501
title: Gene expression profile of liver tissue of C57BL/6J mice infected with T. marneffei.csv

description: <i>T. marneffei</i> infection results in liver damage in the host. Here, we present the gene expression profile of <i>T. marneffei </i>infection in the liver tissue of C57BL/6J mice. An infection model was established by intravenous injection of <i>T. marneffei </i>conidia. Liver tissues were collected at 3, 7, and 14 days post-infection, and RNA-seq analysis was performed. The reads were obtained from the sequencing machine and further refined for high-quality clean reads using fastp software (version 0.18.0). HISAT 2.2.4 was employed to map the paired-end clean reads to the reference genome, and the read counts for each individual gene were calculated.
DOI: 10.6084/m9.figshare.24265501.v1
title: Gene expression profile of liver tissue of C57BL/6J mice infected with T. marneffei.csv

description: <i>T. marneffei</i> infection results in liver damage in the host. Here, we present the gene expression profile of <i>T. marneffei </i>infection in the liver tissue of C57BL/6J mice. An infection model was established by intravenous injection of <i>T. marneffei </i>conidia. Liver tissues were collected at 3, 7, and 14 days post-infection, and RNA-seq analysis was performed. The reads were obtained from the sequencing machine and further refined for high-quality clean reads using fastp software (version 0.18.0). HISAT 2.2.4 was employed to map the paired-end clean reads to the reference genome, and the read counts for each individual gene were calculated.