cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.23641/asha.6626222.v1
title: Investigating a nonspeech differentiation task (Small et al., 2018)

description: <b>Purpose: </b>Clinically, a task of alternating tongue lateralization has been used to evaluate the ability to independently control the tongue and jaw, with jaw movement interpreted as a sign of poor tongue–jaw differentiation. However, there is a lack of normative data regarding jaw movement during this task and whether this changes over the course of development. This study quantified relative tongue and jaw movement during alternating tongue lateralization for typical speakers across age ranges and examined whether degree of jaw movement varies as a function of age.<b>Method: </b>Participants were 39 typical children, adolescents, and adults ranging from 6 to 29 years old. A motion capture system was used to track tongue and jaw movement during an alternating tongue lateralization task, and the average relative contribution of the jaw to tongue lateralization was determined for each participant.<b>Results: </b>Age did not correlate significantly with the average relative contribution of the jaw to tongue lateralization. Typical children, adolescents, and adults exhibited wide variability in the degree of jaw movement during this task.<b>Conclusion:</b> Variability among typical speakers in alternating tongue lateralization performance makes it challenging to determine if/when performance should be considered atypical. Clinical findings from this task must be interpreted with caution.<br><b>Supplemental Material S1. </b>Script for kinematic data collection protocol. <br><b>Supplemental Material S2. </b>Data collection procedures: additional details.<br><b>Supplemental Material S3. </b>Criteria for measuring lateralizations from tongue displacement signal.<br><b>Supplemental Material S4. </b>A correlational analysis using the Spearman rank correlation coefficient demonstrated a strong, positive relationship between RCjaw<sub>avg</sub> using jaw displacement<sub>manual</sub> measures and RCjaw<sub>avg</sub> using jaw displacement<sub>timing </sub>measures, which was statistically significant (<i>r</i><sub>s</sub> = .995, <i>n</i> = 23, <i>p</i> &lt; .0005).<br>Small, H. C., McAllister, T., & Grigos, M. I. (2018). Investigating the use of a nonspeech task to measure tongue–jaw differentiation: Findings across typical development. <i>American Journal of Speech-Language Pathology, 27, </i>1030–1038<i>.</i> https://doi.org/10.1044/2018_AJSLP-17-0089<br>
DOI: 10.6084/m9.figshare.6625868
title: medsea_GOTM_diurnal_SST.nc.gz

description: Modelled near-surface diurnal cycle of sea surface temperature in the Mediterranean Sea, 2013-2014.<br>
DOI: 10.6084/m9.figshare.6625868.v1
title: medsea_GOTM_diurnal_SST.nc.gz

description: Modelled near-surface diurnal cycle of sea surface temperature in the Mediterranean Sea, 2013-2014.<br>
DOI: 10.6084/m9.figshare.6625673
title: AGU Network Analysis

description: Data generated from our research study on network analysis of the American Geophysical Union. A preprint of this research has been submitted to EarthArXiv (http://eartharxiv.org).<br>
DOI: 10.6084/m9.figshare.12888410.v1
title: Chromosomal‐level reference genome of the incense tree Aquilaria sinensis

description: Trees in the genus <i>Aquilaria</i> (Thymelaeaceae) are known as lign aloes, and are native to the forests of southeast Asia. Lign aloes produce agarwood as an antimicrobial defence. Agarwood has a long history of cultural and medicinal use, and is of considerable commercial value. However, due to habitat destruction and over collection, lign aloes are threatened in the wild. We present a chromosomal‐level assembly for <i>Aquilaria sinensis</i>, a lign aloe endemic to China known as the incense tree, based on Illumina short‐read, 10X Genomics linked‐read, and Hi‐C sequencing data. Our 783.8 Mbp <i>A. sinensis</i> genome assembly is of high physical contiguity, with a scaffold N50 of 87.6 Mbp, and high completeness, with a 95.8% BUSCO score for eudicotyledon genes. We include 17 transcriptomes from various plant tissues, providing a total of 35,965 gene models. We reveal the first complete set of genes involved in sesquiterpenoid production, plant defence, and agarwood production for the genus <i>Aquilaria</i>, including genes involved in the biosynthesis of sesquiterpenoids via the mevalonic acid (MVA), 1‐deoxy‐D‐xylulose‐5‐phosphate (DXP), and methylerythritol phosphate (MEP) pathways. We perform a detailed repeat content analysis, revealing that transposable elements account for ~61% of the genome, with major contributions from <i>gypsy</i>‐like and <i>copia</i>‐like LTR retroelements. We also provide a comparative analysis of repeat content across sequenced species in the order Malvales. Our study reveals the first chromosomal‐level genome assembly for a tree in the genus <i>Aquilaria</i> and provides an unprecedented opportunity to address a variety of applied, genomic and evolutionary questions in the Thymelaeaceae more widely.
DOI: 10.6084/m9.figshare.6622370
title: Differential protein-protein binding affinities of H-NS family proteins encoded on the chromosome of <i>Pseudomonas putida</i> KT2440 and IncP-7 plasmid pCAR1

description: H-NS family proteins encoded on the chromosome of <i>Pseudomonas putida</i> KT2440 (TurA and TurB) and the IncP-7 plasmid pCAR1 (Pmr) commonly have an N-terminal dimerization/oligomerization domain constituted by a central and a terminal dimerization sites. To clarify the dimerization manner at the central dimerization sites of the three homologs, we performed chemical cross-linking analyses with protein variants inactivated at the terminal dimerization site. Comparison of the hetero-dimer ratios among them suggested stronger affinities between the central dimerization sites of TurA and TurB monomers than between TurA and Pmr or TurB and Pmr. Furthermore, analyses of the interaction between truncated TurB containing only a functional terminal dimerization site and full-length proteins suggested that TurB exhibited higher affinities for oligomer complex formation with TurB itself and TurA but not Pmr. Altogether, we revealed stronger interaction between the N-terminal domains of TurA and TurB than between either of them and Pmr. Binding affinities between the chromosomally-encoded H-NS family proteins TurA and TurB were stronger than between either of them and the plasmid-encoded Pmr.
DOI: 10.6084/m9.figshare.6622370.v2
title: Differential protein-protein binding affinities of H-NS family proteins encoded on the chromosome of <i>Pseudomonas putida</i> KT2440 and IncP-7 plasmid pCAR1

description: H-NS family proteins encoded on the chromosome of <i>Pseudomonas putida</i> KT2440 (TurA and TurB) and the IncP-7 plasmid pCAR1 (Pmr) commonly have an N-terminal dimerization/oligomerization domain constituted by a central and a terminal dimerization sites. To clarify the dimerization manner at the central dimerization sites of the three homologs, we performed chemical cross-linking analyses with protein variants inactivated at the terminal dimerization site. Comparison of the hetero-dimer ratios among them suggested stronger affinities between the central dimerization sites of TurA and TurB monomers than between TurA and Pmr or TurB and Pmr. Furthermore, analyses of the interaction between truncated TurB containing only a functional terminal dimerization site and full-length proteins suggested that TurB exhibited higher affinities for oligomer complex formation with TurB itself and TurA but not Pmr. Altogether, we revealed stronger interaction between the N-terminal domains of TurA and TurB than between either of them and Pmr. Binding affinities between the chromosomally-encoded H-NS family proteins TurA and TurB were stronger than between either of them and the plasmid-encoded Pmr.
DOI: 10.6084/m9.figshare.6621923
title: Restroom Use Data

description: Data on restroom use in three buildings on UCLA Campus
DOI: 10.6084/m9.figshare.6621695
title: The data of spleen immune indexes of BAL-Bc mice (H22) after treatment for 10 days

description: <b>The result of spleen immune indexes of BALB/c mice (H22) after treatment for 10 days.</b>
DOI: 10.6084/m9.figshare.6621695.v1
title: The data of spleen immune indexes of BAL-Bc mice (H22) after treatment for 10 days

description: <b>The result of spleen immune indexes of BALB/c mice (H22) after treatment for 10 days.</b>
DOI: 10.6084/m9.figshare.6621683.v2
title: SGLT2 Inhibitors in Type 2 Diabetes Management: Key Evidence and Implications for Clinical Practice

description: <b>Article full text</b> <br> The full text of this article can be found here<b>.</b> <br> <b>Provide enhanced content for this article</b> <br> If you are an author of this publication and would like to provide additional enhanced content for your article then please contact <b>adisrapidplus@springer.com</b>. <br> The journal offers a range of additional features designed to increase visibility and readership. All features will be thoroughly peer reviewed to ensure the content is of the highest scientific standard and all features are marked as ‘peer reviewed’ to ensure readers are aware that the content has been reviewed to the same level as the articles they are being presented alongside. Moreover, all sponsorship and disclosure information is included to provide complete transparency and adherence to good publication practices. This ensures that however the content is reached the reader has a full understanding of its origin. No fees are charged for hosting additional open access content. <br> Other enhanced features include, but are not limited to: <br> • Slide decks • Videos and animations • Audio abstracts • Audio slides<br>
DOI: 10.6084/m9.figshare.6621680
title: The sleep assay data after N6-(2-hydroxyethyl) adenosine treatment in mice

description: The effect of N6-(2-hydroxyethyl) adenosine (HEA) was compared with that of estazolam using a short-term treatment of insomnia model. At two doses, 16 and 32 mg/kg, significant effects (P&lt;0.01, P&lt;0.05, respectively) were identified, similar to those in the estazolam group. HEA reduced autonomous activity in mice, shortened the time before sleep and extended the sleep time in a dose-dependent manner.
DOI: 10.6084/m9.figshare.6621680.v1
title: The sleep assay data after N6-(2-hydroxyethyl) adenosine treatment in mice

description: The effect of N6-(2-hydroxyethyl) adenosine (HEA) was compared with that of estazolam using a short-term treatment of insomnia model. At two doses, 16 and 32 mg/kg, significant effects (P&lt;0.01, P&lt;0.05, respectively) were identified, similar to those in the estazolam group. HEA reduced autonomous activity in mice, shortened the time before sleep and extended the sleep time in a dose-dependent manner.
DOI: 10.6084/m9.figshare.6621653
title: The anti-liver cancer effect of ergosterol in mice

description: we analyzed the antitumor effect of ergosterol using H22 hepatoma model mice, ergosterol at a dose of 240 mg/kg for 10 days significantly reduced H22 hepatoma growth. At this dosage, the tumor inhibition rate reached 64.4%. At a lower dosage of 80 mg/kg for 10 days, ergosterol still showed a significant tumor inhibition effect of 41.1%.
DOI: 10.6084/m9.figshare.6621653.v2
title: The anti-liver cancer effect of ergosterol in mice

description: we analyzed the antitumor effect of ergosterol using H22 hepatoma model mice, ergosterol at a dose of 240 mg/kg for 10 days significantly reduced H22 hepatoma growth. At this dosage, the tumor inhibition rate reached 64.4%. At a lower dosage of 80 mg/kg for 10 days, ergosterol still showed a significant tumor inhibition effect of 41.1%.
DOI: 10.6084/m9.figshare.6621653.v1
title: The anti-lewis lung canser effect of ergosterol in mice

description: we analyzed the antitumor effect of ergosterol using H22 hepatoma model mice, ergosterol at a dose of 240 mg/kg for 10 days significantly reduced H22 hepatoma growth. At this dosage, the tumor inhibition rate reached 64.4%. At a lower dosage of 80 mg/kg for 10 days, ergosterol still showed a significant tumor inhibition effect of 41.1%.
DOI: 10.6084/m9.figshare.6621635
title: The anti-lewis lung cancer effect of ergosterol in mice

description: We analyzed the antitumor effect of ergosterol using two the lewis lung tumor model, at a daily oral dose of 240 mg/kg for 10 days, ergosterol had a significant curative effect compared with the effect of no treatment (P&lt;0.01), and the results were the same as for cyclophosphamide.
DOI: 10.6084/m9.figshare.6621635.v1
title: The anti-lewis lung canser effect of ergosterol in mice

description: We analyzed the antitumor effect of ergosterol using two cancer models in mice. In the Lewis lung tumor model, at a daily oral dose of 240 mg/kg for 10 days, ergosterol had a significant curative effect compared with the effect of no treatment (P&lt;0.01), and the results were the same as for cyclophosphamide.
DOI: 10.6084/m9.figshare.6621635.v2
title: The anti-lewis lung canser effect of ergosterol in mice

description: We analyzed the antitumor effect of ergosterol using two the lewis lung tumor model, at a daily oral dose of 240 mg/kg for 10 days, ergosterol had a significant curative effect compared with the effect of no treatment (P&lt;0.01), and the results were the same as for cyclophosphamide.
DOI: 10.6084/m9.figshare.6621635.v4
title: The anti-lewis lung cancer effect of ergosterol in mice

description: We analyzed the antitumor effect of ergosterol using two the lewis lung tumor model, at a daily oral dose of 240 mg/kg for 10 days, ergosterol had a significant curative effect compared with the effect of no treatment (P&lt;0.01), and the results were the same as for cyclophosphamide.
DOI: 10.6084/m9.figshare.6621635.v3
title: The anti-lewis lung cancser effect of ergosterol in mice

description: We analyzed the antitumor effect of ergosterol using two the lewis lung tumor model, at a daily oral dose of 240 mg/kg for 10 days, ergosterol had a significant curative effect compared with the effect of no treatment (P&lt;0.01), and the results were the same as for cyclophosphamide.
DOI: 10.6084/m9.figshare.6621464
title: Supplementary Material for: Gestational Age and the Cord Blood Lipidomic Profile in Late Preterm and Term Infants

description: <b><i>Background:</i></b> Lipid metabolism is vital to fetal development and cardiometabolic health and the final weeks of gestation are known to be a time of intense metabolic activity. New techniques such as lipidomics allow investigation of a complex lipidomic profile in infants. <b><i>Objectives:</i></b> This research aimed to (1) describe variations in lipidomic profile in late preterm and term infants and (2) compare variations to an adult lipidomic profile with known clinical implications. <b><i>Methods:</i></b> The Barwon Infant Study (<i>n</i> = 1,074) is a population-derived pre-birth cohort study. The lipidomic profile of cord blood was measured by liquid chromatography-mass spectrometry in 225 participants and the association between gestational age and lipidomic profile was investigated using multiple linear regression adjusting for birth weight, exposure to labour, and infant sex. Patterns of association with gestational age across the lipidomic profile were compared with associations between body mass index (BMI) and lipidomic profile observed among adults in the San Antonia Family Heart Study (<i>n</i> = 994). <b><i>Results:</i></b> Gestational age was independently associated with the abundances of 39% of lipid species. Variations in the lipidomic profile with increasing gestational age were comparable to some variations observed in association with increasing BMI among adults. <b><i>Conclusion:</i></b> There is a strong relationship between gestational age and the cord blood lipid profile at birth, providing further evidence for the importance of metabolic changes of late gestation. A number of the variations in the lipid profile with increasing gestational age are analogous to differences observed in the adult lipid profile with an increasing BMI.
DOI: 10.6084/m9.figshare.6621329
title: Predictive Evidence Threshold Scaling: Does the Evidence Meet a Confirmatory Standard?

description: Making better use of evidence is one of the tenets of modern drug development. This calls for an understanding of the evidential strength of nonconfirmatory evidence relative to a confirmatory standard. Such inferential comparisons can be done via <i>predictive evidence threshold scaling</i> (PETS). Under PETS, the evidence meets a confirmatory standard if the predictive probability of a positive effect reaches the predictive evidence threshold from hypothetical confirmatory data. These probabilities require plausible assumptions about between-trial heterogeneity and potential biases. Two examples are discussed. The first is breakthrough designation, illustrated by a recent Food and Drug Administration approval of crizotinib for the treatment of non-small-cell lung cancer based on phase I and II data. The second is childhood Guillain–Barré syndrome, with sparse children data enriched with adult data. The examples suggest that the evidential strength of nonconfirmatory data can meet a confirmatory standard. This is reassuring for modern drug development, which exploits various types of evidence to inform adaptive licensing decisions. Supplementary materials for this article are available online.
DOI: 10.6084/m9.figshare.6621329.v1
title: Predictive Evidence Threshold Scaling: Does the Evidence Meet a Confirmatory Standard?

description: Making better use of evidence is one of the tenets of modern drug development. This calls for an understanding of the evidential strength of nonconfirmatory evidence relative to a confirmatory standard. Such inferential comparisons can be done via <i>predictive evidence threshold scaling</i> (PETS). Under PETS, the evidence meets a confirmatory standard if the predictive probability of a positive effect reaches the predictive evidence threshold from hypothetical confirmatory data. These probabilities require plausible assumptions about between-trial heterogeneity and potential biases. Two examples are discussed. The first is breakthrough designation, illustrated by a recent Food and Drug Administration approval of crizotinib for the treatment of non-small-cell lung cancer based on phase I and II data. The second is childhood Guillain–Barré syndrome, with sparse children data enriched with adult data. The examples suggest that the evidential strength of nonconfirmatory data can meet a confirmatory standard. This is reassuring for modern drug development, which exploits various types of evidence to inform adaptive licensing decisions. Supplementary materials for this article are available online.
DOI: 10.6084/m9.figshare.6621110
title: Supporting data from Frequency dispersion reveals chromophore diversity and colour-tuning mechanism in parrot feathers

description: Raman spectra and additional information
DOI: 10.25385/zuyd.6620381
title: Mijn ervaring met de zorgrelatie (MEMZ)

description: Goede zorg begint met een goede omgang tussen cliënten en hulpverleners. Als een cliënt zich veilig voelt in de relatie, durft deze makkelijker aan te geven waar hij/zij zich zorgen over maakt. Voor mensen die communicatiekwetsbaar zijn, is het aangaan van belangrijke gesprekken niet vanzelfsprekend. Deze mensen ervaren immers moeilijkheden in het communiceren met hun omgeving. Bijvoorbeeld hebben zij moeite in het begrijpen en/of uiten van informatie door hun fysieke, cognitieve of emotionele beperkingen.<br><br>MEMZ is geschikt voor mensen die moeilijk kunnen spreken, begrijpen, lezen en/of schrijven en/of een kleine woordenschat hebben. MEMZ geeft deze mensen de mogelijkheid om hun ervaringen in de zorgrelatie met de hulpverlener weer te geven. Op basis van de uitkomsten, kan een hulpverlener/een zorginstelling de kwaliteit van zorg verhogen. <br><br>MEMZ bevat vragen over vier verschillende hoofdthema’s: Doen (gedrag): Wat doet de begeleider in de omgang met de cliënt? Onderdelen hiervan zijn: voldoende tijd nemen, met de cliënt praten i.p.v. over de cliënt, vragen hoe het met de cliënt gaat en vriendelijk tegen de cliënt zijn. Begrijpen (begrip): Hoe kan de begeleider zich inleven in de cliënt? Onderdelen hiervan zijn: zich begrepen voelen, jezelf kunnen zijn, eerlijkheid, kennis van de situatie van de cliënt. Samenwerken (collaboratie): Hoe werken de cliënt en de begeleider samen? Onderdelen hiervan zijn: meebeslissen, vertrouwen, samenwerking tussen begeleiders. Een gesprek hebben (communicatie): Hoe praat de begeleider met de cliënt? Onderdelen hiervan zijn: luisteren, begrijpen wat de begeleider zegt.<br> Het instrument kent drie verschillende toepassingen: Digitale versie: MEMZ-App: voor gebruik door een cliënt, onafhankelijk van een begeleider (te gebruiken via de website: https://mijnervaringmetdezorgrelatie.nl) Analoge versie: MEMZ-Bord: voor gebruik door een cliënt, samen met een begeleider (digitaal mogelijkheid voor documentatie)Groepsversie: MEMZ-Groepsspel: voor gebruik met een groep van cliënten, samen met 1 – 2 begeleiders.<br>Zuyd Hogeschool, lectoraat Autonomie en participatie in samenwerking met: Huis voor de Zorg / Burgerkracht LimburgStichting Gehandicaptenzorg LimburgKoraal GroepViralis Woonzorg groepErgotherapiepraktijk Zuid LimburgAlzheimer Nederland Parkstad LimburgLunet ZorgFontysUniversiteit MaastrichtNivelStichting PLSVector 4 Software SolutionsEIZT
DOI: 10.6084/m9.figshare.6620360
title: Supplementary Material for: Retinal Endovascular Surgery with Tissue Plasminogen Activator Injection for Central Retinal Artery Occlusion

description: <b><i>Purpose:</i></b> To report 2 cases of central retinal artery occlusion (CRAO) who underwent retinal endovascular surgery with injection of tissue plasminogen activator (tPA) into the retinal artery and showed a remarkable improvement in visual acuity and retinal circulation. <b><i>Methods:</i></b> Standard 25-G vitrectomy was performed under local anesthesia. Simultaneously, tPA (80,000 units/mL) solution was injected into the retinal artery of the optic disc for 2–3 min using a microneedle. Changes in visual acuity, fundus photography, optical coherence tomography (OCT), fluorescein angiography, and laser speckle flowgraphy (LSFG) results were examined. <b><i>Results:</i></b> Both cases could be treated within 12 h after the onset of CRAO. Case 1 was a 47-year-old woman. Her visual acuity improved from counting fingers before operation to 0.08 logMAR 1 month after the surgery. However, thinning of the retina at the macula was observed by OCT. Case 2 was a 70-year-old man. His visual acuity improved from counting fingers to 0.1 logMAR 2 months after the surgery. Both fluorescein angiography and LSFG showed improvement in retinal circulation after the surgery in case 2. <b><i>Conclusions:</i></b> Retinal endovascular surgery with injection of tPA into the retinal artery was feasible and may be a way to improve visual acuity and retinal circulation when performed in the acute phase of CRAO.