cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.15468/dl.ymgaqf
title: Occurrence Download

description: A dataset listing the 4 species recorded in GBIF matching the query:
{
 "and" : [
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 "TaxonKey is Arcella hemisphaerica Perty, 1852"
 ]
}

 The dataset's 4 records were derived from 24 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0001241-250402121839773/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.6084/m9.figshare.24843621.v1
title: Transcription factors in the development and treatment of immune disorders

description: Immune function is highly controlled at the transcriptional level by the binding of transcription factors (TFs) to promoter and enhancer elements. Several TF families play major roles in immune gene expression, including NF-κB, STAT, IRF, AP-1, NRs, and NFAT, which trigger anti-pathogen responses, promote cell differentiation, and maintain immune system homeostasis. Aberrant expression, activation, or sequence of isoforms and variants of these TFs can result in autoimmune and inflammatory diseases as well as hematological and solid tumor cancers. For this reason, TFs have become attractive drug targets, even though most were previously deemed “undruggable” due to their lack of small molecule binding pockets and the presence of intrinsically disordered regions. However, several aspects of TF structure and function can be targeted for therapeutic intervention, such as ligand-binding domains, protein–protein interactions between TFs and with cofactors, TF-DNA binding, TF stability, upstream signaling pathways, and TF expression. In this review, we provide an overview of each of the important TF families, how they function in immunity, and some related diseases they are involved in. Additionally, we discuss the ways of targeting TFs with drugs along with recent research developments in these areas and their clinical applications, followed by the advantages and disadvantages of targeting TFs for the treatment of immune disorders.
DOI: 10.6084/m9.figshare.24843621
title: Transcription factors in the development and treatment of immune disorders

description: Immune function is highly controlled at the transcriptional level by the binding of transcription factors (TFs) to promoter and enhancer elements. Several TF families play major roles in immune gene expression, including NF-κB, STAT, IRF, AP-1, NRs, and NFAT, which trigger anti-pathogen responses, promote cell differentiation, and maintain immune system homeostasis. Aberrant expression, activation, or sequence of isoforms and variants of these TFs can result in autoimmune and inflammatory diseases as well as hematological and solid tumor cancers. For this reason, TFs have become attractive drug targets, even though most were previously deemed “undruggable” due to their lack of small molecule binding pockets and the presence of intrinsically disordered regions. However, several aspects of TF structure and function can be targeted for therapeutic intervention, such as ligand-binding domains, protein–protein interactions between TFs and with cofactors, TF-DNA binding, TF stability, upstream signaling pathways, and TF expression. In this review, we provide an overview of each of the important TF families, how they function in immunity, and some related diseases they are involved in. Additionally, we discuss the ways of targeting TFs with drugs along with recent research developments in these areas and their clinical applications, followed by the advantages and disadvantages of targeting TFs for the treatment of immune disorders.
DOI: 10.6084/m9.figshare.28528682
title: Harnessing p53 for targeted cancer therapy: new advances and future directions

description: The transcription factor p53 is the most frequently impaired tumor suppressor in human cancers. In response to various stress stimuli, p53 activates transcription of genes that mediate its tumor-suppressive functions. Distinctive characteristics of p53 outlined here enable a well-defined program of genes involved in cell cycle arrest, apoptosis, senescence, differentiation, metabolism, autophagy, DNA repair, anti-viral response, and anti-metastatic functions, as well as facilitating autoregulation within the p53 network. This versatile, anti-cancer network governed chiefly by a single protein represents an immense opportunity for targeted cancer treatment, since about half of human tumors retain unmutated p53. During the last two decades, numerous compounds have been developed to block the interaction of p53 with the main negative regulator MDM2. However, small molecule inhibitors of MDM2 only induce a therapeutically desirable apoptotic response in a limited number of cancer types. Moreover, clinical trials of the MDM2 inhibitors as monotherapies have not met expectations and have revealed hematological toxicity as a characteristic adverse effect across this drug class. Currently, combination treatments are the leading strategy for enhancing efficacy and reducing adverse effects of MDM2 inhibitors. This review summarizes efforts to identify and test therapeutics that work synergistically with MDM2 inhibitors. Two main types of drugs have emerged among compounds used in the following combination treatments: first, modulators of the p53-regulated transcriptome (including chromatin modifiers), translatome, and proteome, and second, drugs targeting the downstream pathways such as apoptosis, cell cycle arrest, DNA repair, metabolic stress response, immune response, ferroptosis, and growth factor signaling. Here, we review the current literature in this field, while also highlighting overarching principles that could guide target selection in future combination treatments.
DOI: 10.6084/m9.figshare.28528682.v1
title: Harnessing p53 for targeted cancer therapy: new advances and future directions

description: The transcription factor p53 is the most frequently impaired tumor suppressor in human cancers. In response to various stress stimuli, p53 activates transcription of genes that mediate its tumor-suppressive functions. Distinctive characteristics of p53 outlined here enable a well-defined program of genes involved in cell cycle arrest, apoptosis, senescence, differentiation, metabolism, autophagy, DNA repair, anti-viral response, and anti-metastatic functions, as well as facilitating autoregulation within the p53 network. This versatile, anti-cancer network governed chiefly by a single protein represents an immense opportunity for targeted cancer treatment, since about half of human tumors retain unmutated p53. During the last two decades, numerous compounds have been developed to block the interaction of p53 with the main negative regulator MDM2. However, small molecule inhibitors of MDM2 only induce a therapeutically desirable apoptotic response in a limited number of cancer types. Moreover, clinical trials of the MDM2 inhibitors as monotherapies have not met expectations and have revealed hematological toxicity as a characteristic adverse effect across this drug class. Currently, combination treatments are the leading strategy for enhancing efficacy and reducing adverse effects of MDM2 inhibitors. This review summarizes efforts to identify and test therapeutics that work synergistically with MDM2 inhibitors. Two main types of drugs have emerged among compounds used in the following combination treatments: first, modulators of the p53-regulated transcriptome (including chromatin modifiers), translatome, and proteome, and second, drugs targeting the downstream pathways such as apoptosis, cell cycle arrest, DNA repair, metabolic stress response, immune response, ferroptosis, and growth factor signaling. Here, we review the current literature in this field, while also highlighting overarching principles that could guide target selection in future combination treatments.
DOI: 10.15468/dl.d99gxu
title: Occurrence Download

description: A dataset containing 7539 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Ficus sur Forssk.",
 "Continent is Africa"
 ]
}

 The dataset includes 7539 records from 189 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0001251-250402121839773/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.b77gz7
title: Occurrence Download

description: A dataset containing 3253 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Ficus sycomorus L.",
 "Continent is Africa"
 ]
}

 The dataset includes 3253 records from 135 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0001255-250402121839773/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.nvqu46
title: Occurrence Download

description: A dataset containing 19651 species occurrences available in GBIF matching the query:
{
 "DatasetKey" : [
 "is Estudios bióticos (Plantas, Fauna Edáfica, Anfibios y Aves) en los Complejos de páramos Tota-Bijagual-Mamapacha"
 ]
}

 The dataset includes 19651 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0001259-250402121839773/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.vu33hc
title: Occurrence Download

description: A dataset listing the 63 species recorded in GBIF matching the query:
{
 "and" : [
 "Geometry POLYGON((-185.27839 -36.89731,-185.27664 -36.89714,-185.27652 -36.89741,-185.27597 -36.89727,-185.27731 -36.89492,-185.27905 -36.89528,-185.27839 -36.89731))",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present"
 ]
}

 The dataset's 63 records were derived from 9 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0001246-250402121839773/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.f4ee5s
title: Occurrence Download

description: A dataset containing 5034 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Ficus thonningii Blume",
 "Continent is Africa"
 ]
}

 The dataset includes 5034 records from 128 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0001260-250402121839773/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.twr3gh
title: Occurrence Download

description: A dataset containing 41 species occurrences available in GBIF matching the query:
{
 "and" : [
 "BasisOfRecord is Specimen",
 "Continent is North America",
 "Country is Mexico",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "TaxonKey is Saurita Herrich-Schäffer, 1855",
 "Year 1000-2025"
 ]
}

 The dataset includes 41 records from 2 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0001264-250402121839773/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.txukv2
title: Occurrence Download

description: A dataset containing 1379 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Galictis cuja (Molina, 1782)"
 ]
}

 The dataset includes 1379 records from 61 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0001265-250402121839773/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.vkwp3t
title: Occurrence Download

description: A dataset containing 1030 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Ficus trichopoda Baker",
 "Continent is Africa"
 ]
}

 The dataset includes 1030 records from 74 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0001266-250402121839773/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.hyhfmp
title: Occurrence Download

description: A dataset containing 1026 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Ficus vallis-choudae Delile",
 "Continent is Africa"
 ]
}

 The dataset includes 1026 records from 76 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0001267-250402121839773/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.2raepk
title: Occurrence Download

description: A dataset containing 208 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Prunus serrulata f. spontanea (E.H.Wilson) Chin S.Chang"
 ]
}

 The dataset includes 208 records from 12 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0001268-250402121839773/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.93vsha
title: Occurrence Download

description: A dataset containing 450 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Ficus verruculosa Warb.",
 "Continent is Africa"
 ]
}

 The dataset includes 450 records from 34 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0001269-250402121839773/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.mwjs9h
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Pseudophilothrips ichini (Hood, 1949)",
 "HasGeospatialIssue is false",
 "HasCoordinate is true"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0001271-250402121839773/datasets/export for details.
DOI: 10.15468/dl.ehz7d7
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Rhinacloa cardini (Barber & Bruner, 1946)",
 "HasGeospatialIssue is false",
 "HasCoordinate is true"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0001270-250402121839773/datasets/export for details.
DOI: 10.15468/dl.mw6sxd
title: Occurrence Download

description: A dataset containing 91 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Fimbristylis debilis Steud.",
 "Continent is Africa"
 ]
}

 The dataset includes 91 records from 18 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0001273-250402121839773/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.t7u9z6
title: Occurrence Download

description: A dataset containing 1359 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Heliotropium arborescens L."
 ]
}

 The dataset includes 1359 records from 222 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0001276-250402121839773/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.c5a9cy
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Pseudophilothrips ichini (Hood, 1949)",
 "HasCoordinate is true"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0001278-250402121839773/datasets/export for details.
DOI: 10.15468/dl.kaasfw
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Diorhabda carinata",
 "HasCoordinate is true"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0001279-250402121839773/datasets/export for details.
DOI: 10.15468/dl.c2nj4f
title: Occurrence Download

description: A dataset containing 750 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Fimbristylis pilosa Vahl",
 "Continent is Africa"
 ]
}

 The dataset includes 750 records from 42 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0001280-250402121839773/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.gfe8ar
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Rhinacloa cardini (Barber & Bruner, 1946)",
 "HasCoordinate is true"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0001277-250402121839773/datasets/export for details.
DOI: 10.15468/dl.rrje55
title: Occurrence Download

description: A dataset containing 20 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Fimbristylis schweinfurthiana Boeckeler",
 "Continent is Africa"
 ]
}

 The dataset includes 20 records from 7 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0001281-250402121839773/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.1594/pangaea.939109
title: Stable isotope analysis from stomach oil deposit WMM7, Dronning Maud Land

description: Total nitrogen %, total organic carbon % and bulk stable isotope ratios of carbon and nitrogen for stomach-oil deposit WMM7. Standard deviations reported for replicate analyses.
DOI: 10.1594/pangaea.939228
title: Fatty acid and pigment distributions from stomach oil deposit WMM7, Dronning Maud Land

description: Fatty acid and selected pigment distributions from stomach-oil deposit WMM7. Pigments are reported according to the absorbance at 4 key wavelengths (e.g. P410 = absorbance at 410 nm). Absorbances are reported normalised to extracted mass of stomach-oil deposit (abs g-1) and normalised to total organic carbon content (abs gTOC-1).
DOI: 10.1594/pangaea.939229
title: Fatty acid stable carbon isotope ratios from stomach oil deposit WMM7, Dronning Maud Land

description: Fatty acid stable carbon isotope ratios from stomach-oil deposit WMM7. Standard deviations reported for duplicate measurements.
DOI: 10.1594/pangaea.939016
title: XRF data from stomach oil deposit WMM7, Dronning Maud Land

description: XRF analysis of stomach-oil deposit WMM7.
DOI: 10.1594/pangaea.924065
title: Microearthquake catalogue at the Knipovich Ridge 75.5-77.5N from 2016-09 till 2017-07

description: The dataset includes located earthquakes with origin time, location and magnitude and pick information.The dataset consists of 11 months of seismicity data collected by 26 ocean bottom seismometers along around 160 km of the Knipovich Ridge rift axis.Earthquakes were detected using Lassie, automatically picked with PSPicker followed by manual re-picking. Amplitudes were picked automatically with automag in SEISAN. Location was performed using HYPOSAT. The dataset includes all located events without any quality control.
DOI: 10.1594/pangaea.929876
title: Labidura riparia microsatellite corrected data records in Germany
DOI: 10.1594/pangaea.929902
title: Labidura riparia microsatellite raw data records in Germany
DOI: 10.1594/pangaea.929936
title: Labidura riparia microsatellite historical occurrence records in Germany
DOI: 10.1594/pangaea.896500
title: X-ray fluorescence (XRF) measurements on mumiyo deposit PRM8 (profile C) from Petermann Range

description: High-resolution line-scan images were recorded and XRF analysis was carried out with an ITRAX XRF core scanner (Cox Analytical Systems, Sweden). XRF analyses were conducted with a chromium X-ray tube (settings 30 kV and 55 mA), an exposure time of 20 seconds, and a resolution of 500 µm.
DOI: 10.1594/pangaea.896498
title: Elemental analysis of the total carbon, total nitrogen and total sulphur on mumiyo deposit PRM8 from Petermann Range

description: Elemental analysis of the total carbon (C), total nitrogen (N) and total sulphur (S) content was measured with a vario microcube (Elementar, Germany) on 2 mm thick sub-samples of the profile PRM8-A. Due to the sticky consistence of the material the samples could not be homogenized prior to analysis and each sample was measured in four replicates of c. 2.5 mg (± standard deviation of the mean).Contents of total carbon, total nitrogen and total sulphur %, reported values are mean values of 4 replicates and standard deviation of the mean.
DOI: 10.1594/pangaea.896555
title: Elemental analysis of the total carbon, total nitrogen and total sulphur on mumiyo deposit DallSW1830 from Dallmann Berge

description: Elemental analysis of the total carbon (C), total nitrogen (N) and total sulphur (S) content was measured with a vario microcube (Elementar, Germany) on 2 mm thick sub-samples of the profile PRM8-A. Due to the sticky consistence of the material the samples could not be homogenized prior to analysis and each sample was measured in four replicates of c. 2.5 mg (± standard deviation of the mean).Contents of total carbon, total nitrogen and total sulphur %, reported values are mean values of 4 replicates and standard deviation of the mean.
DOI: 10.1594/pangaea.895332
title: Elemental analysis of the total carbon, total nitrogen and total sulphur on mumiyo deposit PRM10 from Petermann Range

description: Elemental analysis of the total carbon (C), total nitrogen (N) and total sulphur (S) content was measured with a vario microcube (Elementar, Germany) on 2 mm thick sub-samples of the profile PRM10-A. Due to the sticky consistence of the material the samples could not be homogenized prior to analysis and each sample was measured in four replicates of c. 2.5 mg (± standard deviation of the mean).
DOI: 10.1594/pangaea.896556
title: X-ray fluorescence (XRF) measurements on mumiyo deposit DallSW1830 (profile A) from Dallmann Berge

description: High-resolution line-scan images were recorded and XRF analysis was carried out with an ITRAX XRF core scanner (Cox Analytical Systems, Sweden). XRF analyses were conducted with a chromium X-ray tube (settings 30 kV and 55 mA), an exposure time of 20 seconds, and a resolution of 500 µm.
DOI: 10.1594/pangaea.944134
title: Microclimatic characteristics measured during the drought year 2018 at the Leipzig Canopy Crane site (15/5/2018-15/9/2018 and 12:00-14:00 CET)

description: Date = date; wisp = mean wind speed in m/s; light = mean total radiation in W/m^2 between; temp = mean ambient temperature in °C; bf10 = mean soil moisture content in m^3/m^3; rain = total daily precipitation in l/m^2.
DOI: 10.1594/pangaea.944137
title: Morphological and physiological tree characteristics of 5 tree species measured during the drought year 2018 at the Leipzig Canopy Crane site (15/5/2018-15/9/2018 and 12:00-14:00 CET)