cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.29634799
title: Multicenter, cross-sectional study of the economic burden of multiple sclerosis and cost-driving factors

description: Multiple sclerosis (MS) is a chronic neurodegenerative disease impacting young adults, reducing quality of life and imposing economic burdens. This study estimated MS costs in Algeria from a societal perspective, analyzed cost variations by disease severity, and provided insights for enhancing MS management and healthcare planning. A cross-sectional, bottom-up cost-of-illness study used a validated questionnaire to collect demographic, clinical, and socioeconomic data from MS patients. Data included disease-modifying therapy (DMT) use, MS course, and EDSS scores. Direct costs (medical and non-medical) and indirect costs (productivity losses from absenteeism and early retirement) were calculated. Cost drivers were analyzed using generalized linear models. Among 354 patients, the total annual societal cost per MS patient was $9,636.5 (95% CI: 9101.2 –10,178), with a mean EDSS score of 3.1 (SD 2.1). Direct costs accounted for 93.31%, with DMTs comprising 94.42% of direct medical costs. Costs rose with disease severity, from $8,697.9 (95% CI: 8060.9–9326.8) for mild MS to $12,450.8 (95% CI: 10137.2 –14,773.6) for severe MS (<i>p</i> &lt; 0.001). This study highlights MS’s economic burden in Algeria, with DMTs as the primary cost driver. Optimized resource allocation and cost-effective DMT strategies are essential to improve MS care.
DOI: 10.6084/m9.figshare.29634799.v1
title: Multicenter, cross-sectional study of the economic burden of multiple sclerosis and cost-driving factors

description: Multiple sclerosis (MS) is a chronic neurodegenerative disease impacting young adults, reducing quality of life and imposing economic burdens. This study estimated MS costs in Algeria from a societal perspective, analyzed cost variations by disease severity, and provided insights for enhancing MS management and healthcare planning. A cross-sectional, bottom-up cost-of-illness study used a validated questionnaire to collect demographic, clinical, and socioeconomic data from MS patients. Data included disease-modifying therapy (DMT) use, MS course, and EDSS scores. Direct costs (medical and non-medical) and indirect costs (productivity losses from absenteeism and early retirement) were calculated. Cost drivers were analyzed using generalized linear models. Among 354 patients, the total annual societal cost per MS patient was $9,636.5 (95% CI: 9101.2 –10,178), with a mean EDSS score of 3.1 (SD 2.1). Direct costs accounted for 93.31%, with DMTs comprising 94.42% of direct medical costs. Costs rose with disease severity, from $8,697.9 (95% CI: 8060.9–9326.8) for mild MS to $12,450.8 (95% CI: 10137.2 –14,773.6) for severe MS (<i>p</i> &lt; 0.001). This study highlights MS’s economic burden in Algeria, with DMTs as the primary cost driver. Optimized resource allocation and cost-effective DMT strategies are essential to improve MS care.
DOI: 10.6084/m9.figshare.29085826
title: Budget impact of lecanemab for medicare beneficiaries with early Alzheimer’s disease in the United States: a subgroup analysis

description: In 2024, Alzheimer’s disease affected approximately 6.9 million Americans aged 65 and older. Current therapies include acetylcholinesterase inhibitors, N-methyl-D-aspartate receptor inhibitors, and monoclonal antibodies. With an economic burden surpassing $345 billion, $222 billion borne by Medicare and Medicaid, this study evaluates lecanemab’s budgetary impact for early AD, including subgroup analyses by gender and race. A budget impact model evaluated LECA for early Alzheimer’s disease, comparing scenarios with and without the therapy. Inputs included market share, costs, duration, and compliance. Gender and race subgroup analyses, annual costs, PMPM, PTMPM, and sensitivity analysis outcomes were assessed to explore parameter-driven variability comprehensively. Introducing LECA for over 3.5 million eligible early AD patients in the U.S. may generate a three-year budget impact of $4.1 billion for Medicare. Incremental PMPM savings were $1.4, and PTMPM savings reached $24.1. Subgroup analyses revealed no significant gender or racial differences in PMPM and PTMPM, with variability only in overall budget impact. Sensitivity analyses indicate that enhanced healthcare resource utilization, reduced disease severity, and improved cost-efficiency among males contribute to strengthening Medicare’s budget sustainability. Utilizing LECA as a treatment for early AD is expected to be cost saving with respect to Medicare budgets in the U.S.
DOI: 10.6084/m9.figshare.29085826.v1
title: Budget impact of lecanemab for medicare beneficiaries with early Alzheimer’s disease in the United States: a subgroup analysis

description: In 2024, Alzheimer’s disease affected approximately 6.9 million Americans aged 65 and older. Current therapies include acetylcholinesterase inhibitors, N-methyl-D-aspartate receptor inhibitors, and monoclonal antibodies. With an economic burden surpassing $345 billion, $222 billion borne by Medicare and Medicaid, this study evaluates lecanemab’s budgetary impact for early AD, including subgroup analyses by gender and race. A budget impact model evaluated LECA for early Alzheimer’s disease, comparing scenarios with and without the therapy. Inputs included market share, costs, duration, and compliance. Gender and race subgroup analyses, annual costs, PMPM, PTMPM, and sensitivity analysis outcomes were assessed to explore parameter-driven variability comprehensively. Introducing LECA for over 3.5 million eligible early AD patients in the U.S. may generate a three-year budget impact of $4.1 billion for Medicare. Incremental PMPM savings were $1.4, and PTMPM savings reached $24.1. Subgroup analyses revealed no significant gender or racial differences in PMPM and PTMPM, with variability only in overall budget impact. Sensitivity analyses indicate that enhanced healthcare resource utilization, reduced disease severity, and improved cost-efficiency among males contribute to strengthening Medicare’s budget sustainability. Utilizing LECA as a treatment for early AD is expected to be cost saving with respect to Medicare budgets in the U.S.
DOI: 10.6084/m9.figshare.29487858
title: Insights derived from testing a library of per- and polyfluoroalkyl substances (PFAS) in a battery of new approach methods (NAMs)

description: Per- and polyfluoroalkyl substances (PFAS) comprise a large class of human-made chemicals that are in widespread use and present concerns for persistence, bioaccumulation and toxicity. Whilst a handful of PFAS have been characterized for their hazard profiles, the vast majority of PFAS have not been extensively studied. A comprehensive evaluation to characterize the hazard profiles of the thousands of available PFAS would require extensive resources in terms of cost, number of animals and time. An alternative and more efficient approach is to develop a structural chemical categorization approach to prioritize which PFAS or categories of PFAS should be subject to additional study. To that end, the U.S. Environmental Protection Agency (EPA), in collaboration with the National Institute of Environmental Health Sciences (NIEHS) Division of Translational Toxicology (DTT), initiated a research project in 2018 to screen approximately 150 PFAS through a battery of alternative model organisms, <i>in vitro</i> cell and biochemical assays, and <i>in vitro</i> toxico kinetic (TK) assays in order to inform chemical category and read-across approaches. The aim of this review summarizes the experimental testing undertaken, how data were processed, what insights were derived from a category perspective and how these might potentially inform subsequent tiered testing.
DOI: 10.6084/m9.figshare.29487858.v1
title: Insights derived from testing a library of per- and polyfluoroalkyl substances (PFAS) in a battery of new approach methods (NAMs)

description: Per- and polyfluoroalkyl substances (PFAS) comprise a large class of human-made chemicals that are in widespread use and present concerns for persistence, bioaccumulation and toxicity. Whilst a handful of PFAS have been characterized for their hazard profiles, the vast majority of PFAS have not been extensively studied. A comprehensive evaluation to characterize the hazard profiles of the thousands of available PFAS would require extensive resources in terms of cost, number of animals and time. An alternative and more efficient approach is to develop a structural chemical categorization approach to prioritize which PFAS or categories of PFAS should be subject to additional study. To that end, the U.S. Environmental Protection Agency (EPA), in collaboration with the National Institute of Environmental Health Sciences (NIEHS) Division of Translational Toxicology (DTT), initiated a research project in 2018 to screen approximately 150 PFAS through a battery of alternative model organisms, <i>in vitro</i> cell and biochemical assays, and <i>in vitro</i> toxico kinetic (TK) assays in order to inform chemical category and read-across approaches. The aim of this review summarizes the experimental testing undertaken, how data were processed, what insights were derived from a category perspective and how these might potentially inform subsequent tiered testing.
DOI: 10.17026/ar/5rxb1x
title: PAN-00173031 - devotional pendant Modern period

description: &lt;p&gt;This find is registered at Portable Antiquities of the Netherlands with number PAN-00173031&lt;/p&gt;
description: Modified: 2025-04-25T12:43:33+02:00
DOI: 10.7910/dvn/pkngcq
title: Dataset for Estimating the cost of immunizing zero-dose children through outreach in Nigeria

description: About this study: This study used a retrospective bottom-up costing approach in three states: Jigawa, Kaduna, and Lagos. In total, 57 health facilities were sampled across 8 LGAs, selected to represent different zero-dose prevalence and geographic contexts. Costs were assessed from the payer perspective, capturing both financial outlays and economic costs. Data were collected between December 2024 and March 2025, including cost data and qualitative interviews on barriers and implementation challenges. Unit costs were calculated as volume-weighted averages, and findings were disaggregated by delivery strategy, state, and ZDROP participation. A qualitative assessment was also conducted alongside the costing to capture providers’ perspectives on the key barriers to vaccinating zero-dose children as well as their recommendations to reduce zero-dose prevalence in their areas. Results are primarily presented as the cost per Penta1 dose delivered to a child of any age due to limited data on Penta1 doses delivered to zero-dose children (aged 12-23 months).

About this file: This file presents the facility-level raw cost data used to estimate the cost of delivering vaccines to zero-dose children. Costs are presented as 2024 USD.
DOI: 10.6084/m9.figshare.25242673
title: Study of follow-the-leader motion through multi-objective optimization of serpentine gait of a bio-inspired snake robot

description: This article presents multi-objective optimization for the efficient locomotion of the serpentine gait of a biologically inspired snake robot. The optimization problem is solved by using multi-objective genetic algorithm approach. The objective functions are the minimization of power consumption and the maximization of the forward propulsion velocity of the robot. The decision variables are the parameters of the serpentine gait, namely as amplitude, angular frequency and phase shift. The snake robot is modeled by using the Newton-Euler dynamic formulation related to locomotion robots. The wheel-ground contact is modeled by using the Coulomb’s law of dry friction. Optimization results are obtained and discussed for a number of coefficients of friction. The results depicted that for the pareto-optimal solutions, the lateral slide of the modules is negligibly small and the snake robot showed a follow-the-leader motion. These results justify the efficient utilization of energy in follow-the-leader approach. Finally, this study provides a useful basis for the selection of appropriate design parameters of snake robot under specified physical constraints and limitations.
DOI: 10.6084/m9.figshare.25242673.v1
title: Study of follow-the-leader motion through multi-objective optimization of serpentine gait of a bio-inspired snake robot

description: This article presents multi-objective optimization for the efficient locomotion of the serpentine gait of a biologically inspired snake robot. The optimization problem is solved by using multi-objective genetic algorithm approach. The objective functions are the minimization of power consumption and the maximization of the forward propulsion velocity of the robot. The decision variables are the parameters of the serpentine gait, namely as amplitude, angular frequency and phase shift. The snake robot is modeled by using the Newton-Euler dynamic formulation related to locomotion robots. The wheel-ground contact is modeled by using the Coulomb’s law of dry friction. Optimization results are obtained and discussed for a number of coefficients of friction. The results depicted that for the pareto-optimal solutions, the lateral slide of the modules is negligibly small and the snake robot showed a follow-the-leader motion. These results justify the efficient utilization of energy in follow-the-leader approach. Finally, this study provides a useful basis for the selection of appropriate design parameters of snake robot under specified physical constraints and limitations.
DOI: 10.17026/ar/899gtq
title: PAN-00173100 - devotional pendant Modern period

description: &lt;p&gt;This find is registered at Portable Antiquities of the Netherlands with number PAN-00173100&lt;/p&gt;
description: Modified: 2025-04-26T11:37:35+02:00
DOI: 10.25318/3310109001-fra
title: Liquidités et accès aux liquidités au cours des trois prochains mois, quatrième trimestre de 2025
DOI: 10.15468/dl.43b97m
title: Occurrence Download

description: A dataset listing the 2 species recorded in GBIF matching the query:
{
 "TaxonKey" : [
 "is Cervus elaphus canadensis"
 ]
}

 The dataset's 2 records were derived from 93 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0020278-251120083545085/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.3334/cdiac/otg.clivar_line_p_2009
title: Dissolved inorganic carbon (DIC), pH on total scale, total alkalinity, water temperature, salinity and other variables collected from discrete sample and profile observations during the R/Vs Endeavour, CCGS John P. Tully and Parizeau Line P cruises in the Coastal Waters of SE Alaska, Gulf of Alaska and North Pacific Ocean from 1985-02-12 to 2017-02-20 (NCEI Accession 0110260)

description: This dataset includes discrete sample and profile observations data collected during the R/Vs Endeavour, CCGS John P. Tully and Parizeau Line P cruises in the Coastal Waters of SE Alaska, Gulf of Alaska and North Pacific Ocean from 1985-02-12 to 2017-02-20. These data include dissolved inorganic carbon (DIC), pH on total scale, total alkalinity, temperature, salinity, dissolved nitrite plus nitrate, phosphate and silicate. The instruments used to collect these data include alkalinity titrator, coulometer for DIC measurement, CTD, Niskin bottles, spectrophotometer and other instruments. These data were collected by Lisa A. Miller of Department of Fisheries and Oceans; Institute of Ocean Sciences; Climate Chemistry Laboratory and James R. Christian, Joe Linguanti, and Marty Davelaar of Fisheries and Oceans Canada; Institute of Ocean Sciences as part of the Line_P dataset. The International CLIVAR Global Ocean Carbon and Repeat Hydrography Program carries out a systematic and global re-occupation of select WOCE/JGOFS hydrographic sections to quantify changes in storage and transport of heat, fresh water, carbon dioxide (CO2), and related parameters.
DOI: 10.15468/dl.926ndq
title: Occurrence Download

description: A dataset listing the 275 species recorded in GBIF matching the query:
{
 "and" : [
 "Country is France",
 "Geometry POLYGON((2.81911 42.51192,2.82831 42.50314,2.84002 42.49338,2.85697 42.4985,2.87233 42.50802,2.87355 42.5135,2.87197 42.52168,2.85236 42.54802,2.82785 42.54875,2.81533 42.54034,2.81314 42.52375,2.81911 42.51192))",
 "TaxonKey is Insecta"
 ]
}

 The dataset's 275 records were derived from 39 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0020276-251120083545085/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.17026/ar/4vpgzd
title: PAN-00173009 - devotional pendant Modern period

description: &lt;p&gt;This find is registered at Portable Antiquities of the Netherlands with number PAN-00173009&lt;/p&gt;
description: Modified: 2025-04-25T12:44:40+02:00
DOI: 10.5281/zenodo.17777669
title: CRITICAL MINERALS SUPPLY CHAINS AND U.S. STRATEGIC INVESTMENT IN CENTRAL ASIA'S MINING SECTOR

description: Geoeconomic competition over the most important minerals - especially tungsten or molybdenum and other materials crucial in defense, aerospace, technology production and clean energy, has become one of the most characteristic geoeconomic challenges in the past 10 years. The United States stepped up between 2015 and 2025 to no longer rely on China but in mineral supply chains and found Central Asia (Uzbekistan and Kazakhstan) as new and value partners. 

This paper revitalizes and builds upon earlier discussion of U.S. investments in the mining industries of Central Asia, incorporating recent events, including the C5+1 Summit of 6 November 2025, in which critical minerals were an item of high discussion. The paper will analyze the geopolitical explanations of the U.S. choice to invest in Uzbekistan and Kazakhstan and how host country reform boosts foreign capital inflows and evaluates the approach of long-term effects on global supply chain resilience by use of qualitative content analysis of policy documents, reforms in Uzbekistan and Kazakhstan and commentary by scholars and institutions. 

These include a table on major U.S. Central Asia mineral agreements and a conceptual map on the C5+1 system of resource diplomacy. On the whole, the results indicate that the U.S. engagement is motivated by security risks, supply chain weakness, and competition with China, whereas Central Asian states use this focus to speed up the mining reforms, draw in investment, and make their geopolitical standing more solid.
DOI: 10.5281/zenodo.17777668
title: CRITICAL MINERALS SUPPLY CHAINS AND U.S. STRATEGIC INVESTMENT IN CENTRAL ASIA'S MINING SECTOR

description: Geoeconomic competition over the most important minerals - especially tungsten or molybdenum and other materials crucial in defense, aerospace, technology production and clean energy, has become one of the most characteristic geoeconomic challenges in the past 10 years. The United States stepped up between 2015 and 2025 to no longer rely on China but in mineral supply chains and found Central Asia (Uzbekistan and Kazakhstan) as new and value partners. 

This paper revitalizes and builds upon earlier discussion of U.S. investments in the mining industries of Central Asia, incorporating recent events, including the C5+1 Summit of 6 November 2025, in which critical minerals were an item of high discussion. The paper will analyze the geopolitical explanations of the U.S. choice to invest in Uzbekistan and Kazakhstan and how host country reform boosts foreign capital inflows and evaluates the approach of long-term effects on global supply chain resilience by use of qualitative content analysis of policy documents, reforms in Uzbekistan and Kazakhstan and commentary by scholars and institutions. 

These include a table on major U.S. Central Asia mineral agreements and a conceptual map on the C5+1 system of resource diplomacy. On the whole, the results indicate that the U.S. engagement is motivated by security risks, supply chain weakness, and competition with China, whereas Central Asian states use this focus to speed up the mining reforms, draw in investment, and make their geopolitical standing more solid.
DOI: 10.5281/zenodo.17777638
title: Endothelial Cells Angiogenesis in Sulfated Glycosaminoglycan (GAG) Hydrogels Enhanced by Bioactive Glass-Released Ions
DOI: 10.5281/zenodo.17777637
title: Endothelial Cells Angiogenesis in Sulfated Glycosaminoglycan (GAG) Hydrogels Enhanced by Bioactive Glass-Released Ions
DOI: 10.5281/zenodo.16908828
title: gapseq reference sequence databases for Bacteria and Archaea

description: The repository contains the protein sequences used by gapseq to predict the presence of metabolic reactions and to construct metabolic models.
DOI: 10.5281/zenodo.10047603
title: gapseq reference sequence databases for Bacteria and Archaea

description: The repository contains the protein sequences used by gapseq to predict the presence of metabolic reactions and to construct metabolic models.
DOI: 10.17026/ar/nrt8ec
title: PAN-00130701 - eye brooch

description: &lt;p&gt;This find is registered at Portable Antiquities of the Netherlands with number PAN-00130701&lt;/p&gt;
description: Modified: 2025-04-29T12:14:07+02:00
DOI: 10.34740/kaggle/dsv/13764152
title: 4SQR Dataset
DOI: 10.13140/rg.2.2.32467.64806
title: References
DOI: 10.17026/ar/wq7zl1
title: PAN-00166146 - coin/coin-related, (anoniem, bisschoppelijk), “Friese” penning

description: &lt;p&gt;This find is registered at Portable Antiquities of the Netherlands with number PAN-00166146&lt;/p&gt;
description: Modified: 2025-04-28T13:23:58+02:00
DOI: 10.5281/zenodo.14603318
title: MIrROR

description: MIrROR (Microbial Identification using rRNA Operon Region) is a curated database of 16S-ITS-23S rRNA operon sequences, enabling high-resolution microbial identification and advanced microbial research.

 

▍MIrROR release 02 Coverage Summary




Collected microbial genomes
Total operon sequence
Genomes covering operons
Species covering operons


1,690,470
476,579
249,907
29,051




 

▍Taxonomic Distribution




 
Phylum
Class
Order
Family
Genus
Species


Bacteria
137
327
890
1,897
6,925
27,718


Archaea
19
44
85
243
559
1,333
DOI: 10.5281/zenodo.17639192
title: MIrROR

description: MIrROR (Microbial Identification using rRNA Operon Region) is a curated database of 16S-ITS-23S rRNA operon sequences, enabling high-resolution microbial identification and advanced microbial research.

 

▍MIrROR release 02 Coverage Summary




Collected microbial genomes
Total operon sequence
Genomes covering operons
Species covering operons


1,690,470
476,579
249,907
29,051




 

▍Taxonomic Distribution




 
Phylum
Class
Order
Family
Genus
Species


Bacteria
137
327
890
1,897
6,925
27,718


Archaea
19
44
85
243
559
1,333
DOI: 10.17026/ar/u3swe1
title: PAN-00114551 - coin/coin-related, Edward I, II of III (1272-1307-1327-1377), penny

description: &lt;p&gt;This find is registered at Portable Antiquities of the Netherlands with number PAN-00114551&lt;/p&gt;
description: Modified: 2025-04-28T13:20:57+02:00
DOI: 10.5284/1138328
title: Informing the Future of the Past

description: These guidelines have been developed to assist those who manage, work in and use Historic Environment Records (HERs). They provide an introduction to the HERs and the services that they provide, set out agreed guidelines for working practices, support the delivery of training information and advice, and provide a guide to all aspects of HER management, working practices, standards, systems and services.

This new edition in wiki format constitutes a major revision and expansion from the first two editions to include recent developments and covers Wales and Scotland as well as England with numerous case studies. The publication is the result of a collaboration between Historic England, Historic Environment Scotland, the Royal Commission on the Ancient and Historical Monuments of Wales (RCAHMW), the Association of Local Government Archaeological Officers UK (ALGAO UK) and the Archaeology Data Service (ADS).