cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.24047481.v2
title: <b>Targeting Cancer Cell Signaling Using Precision Oncology Towards a Holistic Approach to Cancer Therapeutics</b>

description: Cancer is a complex disease having a number of composite problems to be considered including cancer immune evasion, therapy resistance, and recurrence for a cure. Fundamentally, it remains a genetic disease as diverse aspects of the complexity of tumor growth and cancer development relate to its genetic machinery and require addressing the problems at the level of genome and epigenome. Importantly, patients with the same cancer types respond differently to cancer therapies indicating the need for patient-specific treatment options. Precision oncology is a form of cancer therapy that focuses on the genetic profiling of tumors to identify molecular alterations involved in cancer development for custom-tailored personalized treatment of the deadly disease. This article aims to briefly explain the foundations and frontiers of precision oncology in the context of ongoing technological advances in this regard to assess its scope and importance in the realization of a proper cure for cancer.
DOI: 10.5281/zenodo.10251466
title: Immunogenomic analyses of high-grade serous ovarian cancer (HGSOC)

description: High-grade serous ovarian cancer (HGSOC) remains the most lethal gynecologic malignancy despite new therapeutic concepts, including poly-ADP-ribose polymerase inhibitors (PARPis) and antiangiogenic therapy. In this study, we have analyzed homologous recombination repair deficiency (HRD) or BRCAness and the composition of the tumor microenvironment, which appear to play a critical role in determining the therapeutic response of combination immunotherapy with PARPis. The used datasets include RNA sequencing data and clinical information from patients of a new HGSOC cohort of the Medical University of Innsbruck (MUI) (n=60) and analyzed data from The Cancer Genome Atlas (TCGA) (n=226).
DOI: 10.5281/zenodo.10251467
title: Immunogenomic analyses of high-grade serous ovarian cancer (HGSOC)

description: High-grade serous ovarian cancer (HGSOC) remains the most lethal gynecologic malignancy despite new therapeutic concepts, including poly-ADP-ribose polymerase inhibitors (PARPis) and antiangiogenic therapy. In this study, we have analyzed homologous recombination repair deficiency (HRD) or BRCAness and the composition of the tumor microenvironment, which appear to play a critical role in determining the therapeutic response of combination immunotherapy with PARPis. The used datasets include RNA sequencing data and clinical information from patients of a new HGSOC cohort of the Medical University of Innsbruck (MUI) (n=60) and analyzed data from The Cancer Genome Atlas (TCGA) (n=226).
DOI: 10.5281/zenodo.10229554
title: phylogenetically compressed 661k mbgc v2.

description: Phylogenetically compressed 661k collection with MBGC v2.0 as a low-level compressor (resulting size: 17.5 GB = 16.30 GiB). More information can be found on https://brinda.eu/mof/.
DOI: 10.5281/zenodo.10229555
title: phylogenetically compressed 661k mbgc v2.

description: Phylogenetically compressed 661k collection with MBGC v2.0 as a low-level compressor (resulting size: 17.5 GB = 16.30 GiB). More information can be found on https://brinda.eu/mof/.
DOI: 10.6084/m9.figshare.24716430.v1
title: (paper) Quantum Biochemical Analysis of the Binding Interactions Between a Potential Inhibitory Drugand the Ebola Viral Glycoprotein

description: Ebola virus disease (EVD) causes outbreaks and epidemics in West Africa that persist until today. The envelope glycoprotein of Ebola virus (GP) consists of two subunits, GP1 and GP2, and plays a key role in anchoring or fusing the virus to the host cell in its active form on the virion surface. Toremifene (TOR) is a ligand that mainly acts as an estrogen receptor antagonist; however, a recent study showed a strong and efficient interaction with GP. In this context, we aimed to evaluate the energetic affinity features involved in the interaction between GP and toremifene by computer simulation techniques using the Molecular Fractionation Method with Conjugate Caps (MFCC) scheme and quantum-mechanical (QM) calculations, as well as missense mutations to assess protein stability. We identified ASP522, GLU100, TYR517, THR519, LEU186, LEU515 as the most attractive residues in the EBOV glycoprotein structure that form the binding pocket. We divided toremifene into three regions and evaluated that region i was more important than region iii and region ii for the formation of the TOR-GP1/GP2 complex, which might control the molecular remodeling process of TOR. The mutations that caused more destabilization were ARG134, LEU515, TYR517 and ARG559, while those that caused stabilization were GLU523 and ASP522. TYR517 is a critical residue for the binding of TOR, and is highly conserved among EBOV species. Our results may help to elucidate the mechanism of drug action on the GP protein of Ebola virus and subsequently develop new pharmacological approaches against EVD.
DOI: 10.6084/m9.figshare.24716430
title: (paper) Quantum Biochemical Analysis of the Binding Interactions Between a Potential Inhibitory Drugand the Ebola Viral Glycoprotein

description: Ebola virus disease (EVD) causes outbreaks and epidemics in West Africa that persist until today. The envelope glycoprotein of Ebola virus (GP) consists of two subunits, GP1 and GP2, and plays a key role in anchoring or fusing the virus to the host cell in its active form on the virion surface. Toremifene (TOR) is a ligand that mainly acts as an estrogen receptor antagonist; however, a recent study showed a strong and efficient interaction with GP. In this context, we aimed to evaluate the energetic affinity features involved in the interaction between GP and toremifene by computer simulation techniques using the Molecular Fractionation Method with Conjugate Caps (MFCC) scheme and quantum-mechanical (QM) calculations, as well as missense mutations to assess protein stability. We identified ASP522, GLU100, TYR517, THR519, LEU186, LEU515 as the most attractive residues in the EBOV glycoprotein structure that form the binding pocket. We divided toremifene into three regions and evaluated that region i was more important than region iii and region ii for the formation of the TOR-GP1/GP2 complex, which might control the molecular remodeling process of TOR. The mutations that caused more destabilization were ARG134, LEU515, TYR517 and ARG559, while those that caused stabilization were GLU523 and ASP522. TYR517 is a critical residue for the binding of TOR, and is highly conserved among EBOV species. Our results may help to elucidate the mechanism of drug action on the GP protein of Ebola virus and subsequently develop new pharmacological approaches against EVD.
DOI: 10.34740/kaggle/dsv/7107508
title: High School Alcoholism and Academic Performance
DOI: 10.34740/kaggle/ds/4087335
title: High School Alcoholism and Academic Performance
DOI: 10.6073/pasta/399c5fd6975c41c78686409dfcd804d0
title: Jornada Basin LTER Cross-scale Interactions Study (CSIS) Block 2 meteorological station: Daily summary data: 2013 - ongoing

description: This data package contains hourly air temperature, relative humidity, wind speed, wind direction, and precipitation summary data from Jornada Basin LTER Cross Scale Interactions Study (CSIS) Block-2 met station. Air temperature, relative humidity, wind speed, wind direction, and precipitation are measured and calculated at an automated meteorological station connected to a 900 MHz spread spectrum wireless network. Wind speed is measured at 37cm, 75 cm, 150 cm, and 300 cm, wind direction at approximately 3m, and air temperature and relative humidity at approximate 2.5m. Measurements are aggregated at intervals of 5, 30, 60 minutes and daily, with precipitation additionally provided with 1 second aggregation during precipitation events. The met station variables measured include air temperature, precipitation, relative humidity, wind direction, wind speed. Precipitation is not measured at Block 1 and Block 12 because of proximity to Block 2 and Block 13, respectively . This is an ONGOING dataset.
DOI: 10.6073/pasta/1a39da2c83ee8e59926539ac21d2178c
title: Jornada Basin LTER Cross-scale Interactions Study (CSIS) Block 11 meteorological station: Daily summary data: 2013 - ongoing

description: This data package contains hourly air temperature, relative humidity, wind speed, wind direction, and precipitation summary data from Jornada Basin LTER Cross Scale Interactions Study (CSIS) Block-11 met station. Air temperature, relative humidity, wind speed, wind direction, and precipitation are measured and calculated at an automated meteorological station connected to a 900 MHz spread spectrum wireless network. Wind speed is measured at 37cm, 75 cm, 150 cm, and 300 cm, wind direction at approximately 3m, and air temperature and relative humidity at approximate 2.5m. Measurements are aggregated at intervals of 5, 30, 60 minutes and daily, with precipitation additionally provided with 1 second aggregation during precipitation events. The met station variables measured include air temperature, precipitation, relative humidity, wind direction, wind speed. Precipitation is not measured at Block 1 and Block 12 because of proximity to Block 2 and Block 13, respectively . This is an ONGOING dataset.
DOI: 10.6073/pasta/d1ae95ab9e05c6b98e4356f4b1259c50
title: Jornada Basin LTER Cross-scale Interactions Study (CSIS) Block 7 meteorological station: Daily summary data: 2013 - ongoing

description: This data package contains hourly air temperature, relative humidity, wind speed, wind direction, and precipitation summary data from Jornada Basin LTER Cross Scale Interactions Study (CSIS) Block-7 met station. Air temperature, relative humidity, wind speed, wind direction, and precipitation are measured and calculated at an automated meteorological station connected to a 900 MHz spread spectrum wireless network. Wind speed is measured at 37cm, 75 cm, 150 cm, and 300 cm, wind direction at approximately 3m, and air temperature and relative humidity at approximate 2.5m. Measurements are aggregated at intervals of 5, 30, 60 minutes and daily, with precipitation additionally provided with 1 second aggregation during precipitation events. The met station variables measured include air temperature, precipitation, relative humidity, wind direction, wind speed. Precipitation is not measured at Block 1 and Block 12 because of proximity to Block 2 and Block 13, respectively . This is an ONGOING dataset.
DOI: 10.6073/pasta/e18dfe389cfcc66eba76ae47b05cd5c5
title: Jornada Basin LTER Cross-scale Interactions Study (CSIS) Block 9 meteorological station: Daily summary data: 2013 - ongoing

description: This data package contains hourly air temperature, relative humidity, wind speed, wind direction, and precipitation summary data from Jornada Basin LTER Cross Scale Interactions Study (CSIS) Block-9 met station. Air temperature, relative humidity, wind speed, wind direction, and precipitation are measured and calculated at an automated meteorological station connected to a 900 MHz spread spectrum wireless network. Wind speed is measured at 37cm, 75 cm, 150 cm, and 300 cm, wind direction at approximately 3m, and air temperature and relative humidity at approximate 2.5m. Measurements are aggregated at intervals of 5, 30, 60 minutes and daily, with precipitation additionally provided with 1 second aggregation during precipitation events. The met station variables measured include air temperature, precipitation, relative humidity, wind direction, wind speed. Precipitation is not measured at Block 1 and Block 12 because of proximity to Block 2 and Block 13, respectively . This is an ONGOING dataset.
DOI: 10.5281/zenodo.10251566
title: DrugMol3D: An Expanded Collection of Molecular Data for Optimized Drug Structures and Descriptive Properties
title: DrugMol3D: Uma Coleção Expandida de Dados Moleculares para Estruturas Otimizadas de Fármacos e suas Propriedades
DOI: 10.5281/zenodo.10251567
title: DrugMol3D: An Expanded Collection of Molecular Data for Optimized Drug Structures and Descriptive Properties
title: DrugMol3D: Uma Coleção Expandida de Dados Moleculares para Estruturas Otimizadas de Fármacos e suas Propriedades
DOI: 10.6073/pasta/9f79cc531072d49c5d46798d522acdeb
title: Jornada Basin LTER Cross-scale Interactions Study (CSIS) Block 10 meteorological station: 30-minute summary data: 2017 - ongoing

description: This data package contains 30-minute air temperature, relative humidity, and wind summary data from Jornada Basin LTER Cross Scale Interactions Study (CSIS) Block-1 met station. Average air temperature, relative humidity, wind speed, wind direction, and precipitation are measured and calculated at an automated meteorological station connected to a 900 MHz spread spectrum wireless network. Wind speed is measured at 37cm, 75 cm, 150 cm, and 300 cm, wind direction at approximately 3m, and air temperature and relative humidity at approximate 2.5m. Measurements are aggregated at intervals of 5, 30, 60 minutes and daily, with precipitation additionally provided with 1 second aggregation during precipitation events. The met station variables measured include air temperature, precipitation, relative humidity, wind direction, wind speed. Precipitation is not measured at Block 1 and Block 12 because of proximity to Block 2 and Block 13, respectively. This is an ONGOING dataset.
DOI: 10.25625/601vk8/a6yaoh
title: Replication.tar.gz

description: :unav
DOI: 10.25625/601vk8
title: Replication Data for: On stable discontinuous Galerkin discretizations for Galbrun's equation

description: This dataset contains reproduction material for my Masterthesis "On stable discontinuous Galerkin discretizations for Galbrun's equation". More detailed instructions for replication can be found in the provided README.md file.
DOI: 10.5281/zenodo.10251598
title: Estimating Lexical Complexity in Multi-Domain Settings for the Russian language
DOI: 10.5281/zenodo.10251599
title: Estimating Lexical Complexity in Multi-Domain Settings for the Russian language
DOI: 10.6073/pasta/923a1f797b07db484cdab6d821389ad1
title: Jornada Basin LTER Cross-scale Interactions Study (CSIS) Block 10 meteorological station: 5-minute summary wind and air temperature data: 2013 - ongoing

description: This data package contains 5-minute air temperature and wind summary data from Jornada Basin LTER Cross Scale Interactions Study (CSIS) Block-10 met station. Average air temperature, wind speed, and wind direction are measured and calculated at an automated meteorological station connected to a 900 MHz spread spectrum wireless network. Wind speed is measured at 37cm, 75 cm, 150 cm, and 300 cm, wind direction at approximately 3m, and air temperature and relative humidity at approximate 2.5m. This is a subset of baseline weather data collected at the 15 Jornada Basin LTER CSIS study blocks, New Mexico. Measurements are aggregated at intervals of 5, 30, 60 minutes and daily, with precipitation additionally provided with 1 second aggregation during precipitation events. The met station variables measured include air temperature, precipitation, relative humidity, wind direction, wind speed. Precipitation is not measured at Block 1 and Block 12 because of proximity to Block 2 and Block 13, respectively . This is an ONGOING dataset.
DOI: 10.5281/zenodo.10235603
title: Accountability of Software Intensive Systems: challenges for systems-of-information systems
DOI: 10.5281/zenodo.10235604
title: Accountability of Software Intensive Systems: challenges for systems-of-information systems
DOI: 10.5281/zenodo.10251646
title: Accountability of Software Intensive Systems: challenges for systems-of-information systems
DOI: 10.6073/pasta/7ddb2fd20d72fb61e33d5bdae71a9003
title: Jornada Basin LTER Cross-scale Interactions Study (CSIS) Block 10 meteorological station: 30-minute soil volumetric water content data: 2013 - ongoing

description: 30-minute Soil Moisture data at 10 cm at CSIS Block-10. Collection of soil volumetric water content data at Jornada LTER Cross-scale Interactions Study (CSIS) blocks, New Mexico, supports the environmental monitoring objectives of the Jornada LTER monitoring program that look at plant-soil water dynamics. Soil volumetric water content is measured at 10 cm depth at 3 locations at each of the 4 plots per block. The locations in each plot are under bare soil, under perennial grass, and under shrub. Volumetric water content, bulk electrical conductivity, soil temperature, and bulk dielectric permittivity are recorded every 30 minutes at an automated meteorological station installed at Jornada LTER CSIS Block-10 site. This is an ONGOING dataset.
DOI: 10.6073/pasta/6e300176f6b52a1fd3c77ec1e873b9d5
title: Jornada Basin LTER Cross-scale Interactions Study (CSIS) Block 10 meteorological station: Daily average soil volumetric water content data: 2013 - ongoing

description: Daily Average of 30-minute Soil Volumetric Water Content data at 10 cm at CSIS Block-10. Collection of soil water content data at Jornada LTER Cross-scale Interactions Study (CSIS) blocks, New Mexico, supports the environmental monitoring objectives of the Jornada LTER monitoring program that look at plant-soil water dynamics. Soil volumetric water content is measured every 30 minutes at 10 cm depth at 3 locations at each of the 4 plots per block and averaged for the daily value. The locations in each plot are under bare soil, under perennial grass, and under shrub. Volumetric water content, bulk electrical conductivity, soil temperature, and bulk dielectric permittivity are recorded at an automated meteorological station installed at Jornada LTER CSIS Block-10 site. This is an ONGOING dataset.
DOI: 10.6073/pasta/c0b7315a8ae23acbc433864aa7334eae
title: Jornada Basin LTER Cross-scale Interactions Study (CSIS) Block 10 meteorological station: Daily summary data: 2013 - ongoing

description: This data package contains hourly air temperature, relative humidity, wind speed, wind direction, and precipitation summary data from Jornada Basin LTER Cross Scale Interactions Study (CSIS) Block-10 met station. Air temperature, relative humidity, wind speed, wind direction, and precipitation are measured and calculated at an automated meteorological station connected to a 900 MHz spread spectrum wireless network. Wind speed is measured at 37cm, 75 cm, 150 cm, and 300 cm, wind direction at approximately 3m, and air temperature and relative humidity at approximate 2.5m. Measurements are aggregated at intervals of 5, 30, 60 minutes and daily, with precipitation additionally provided with 1 second aggregation during precipitation events. The met station variables measured include air temperature, precipitation, relative humidity, wind direction, wind speed. Precipitation is not measured at Block 1 and Block 12 because of proximity to Block 2 and Block 13, respectively . This is an ONGOING dataset.
DOI: 10.6073/pasta/f4a98a4a7d153c2dbd64e40830e8eef6
title: Jornada Basin LTER Cross-scale Interactions Study (CSIS) Block 10 meteorological station: 1-second summary precipitation data: 2017 - ongoing

description: 1-second summary precipitation data at CSIS Block-10 met station. Total precipitation per second is recorded only if there is measurable precipitation. This is recorded at an automated meteorological station installed at Jornada LTER CSIS Block-10 site.. This climate station is operated by the Jornada LTER Program. This is an ONGOING dataset. IMPORTANT: Rainfall is only recorded when a bucket tip occurs on the tipping bucket rain gauge. If there is missing data due to equipment or other problems, there will be no indication of this within this dataset. The user needs to review precipitation values in the 30 minute or hourly summary datasets to determine if there are missing data in this 1 second detailed precipitation dataset.
DOI: 10.6073/pasta/6f420d7863755df280a9eae9f4a321c4
title: Jornada Basin LTER Cross-scale Interactions Study (CSIS) Block 11 meteorological station: 30-minute summary data: 2017 - ongoing

description: This data package contains 30-minute air temperature, relative humidity, and wind summary data from Jornada Basin LTER Cross Scale Interactions Study (CSIS) Block-1 met station. Average air temperature, relative humidity, wind speed, wind direction, and precipitation are measured and calculated at an automated meteorological station connected to a 900 MHz spread spectrum wireless network. Wind speed is measured at 37cm, 75 cm, 150 cm, and 300 cm, wind direction at approximately 3m, and air temperature and relative humidity at approximate 2.5m. Measurements are aggregated at intervals of 5, 30, 60 minutes and daily, with precipitation additionally provided with 1 second aggregation during precipitation events. The met station variables measured include air temperature, precipitation, relative humidity, wind direction, wind speed. Precipitation is not measured at Block 1 and Block 12 because of proximity to Block 2 and Block 13, respectively. This is an ONGOING dataset.
DOI: 10.6084/m9.figshare.24716469
title: Dataset SPSS output.docx

description: This data contain of all the SPSS data output consist: 1. SPSS 25 Output Test of Validity and Reliability of the TCCNI Instrument2. SPSS 25 Output Test of Validity and Reliability of the CNPI-23 Instrument3. Univariate Analysis Output (Frequency Distribution and Proportion)4. Bivariate Analysis Output (Chi Square test) Independent Variable and Dependent Variable5. Bivariate Analysis Output (Chi Square test) Confounding Variables: Age of COVID-19 Patients and Dependent Variable6. Bivariate Analysis Output (Chi Square test) Role Variable: Gender of COVID-19 Patient and Dependent Variable7. Bivariate Analysis Output (Chi Square test) Confounding Variables: COVID-19 Patient Education Level and Dependent Variable8. Bivariate Analysis Output (Chi Square test) Confounding Variables: Length of Treatment for COVID-19 Patients and Dependent Variable9. Bivariate Analysis Output (Chi Square test) Confounding Variables: Frequency of Treated COVID-19 Patients and Dependent Variable10. Multivariate Analysis Output (Logistic Regression test)
DOI: 10.34740/kaggle/dsv/7107920
title: Balochi Language to English Translation Dataset
DOI: 10.6073/pasta/fa77777624c9d4b0ee1e54cbf8f2a68c
title: Jornada Basin LTER Cross-scale Interactions Study (CSIS) Block 11 meteorological station: 5-minute summary wind and air temperature data: 2013 - ongoing

description: This data package contains 5-minute air temperature and wind summary data from Jornada Basin LTER Cross Scale Interactions Study (CSIS) Block-11 met station. Average air temperature, wind speed, and wind direction are measured and calculated at an automated meteorological station connected to a 900 MHz spread spectrum wireless network. Wind speed is measured at 37cm, 75 cm, 150 cm, and 300 cm, wind direction at approximately 3m, and air temperature and relative humidity at approximate 2.5m. This is a subset of baseline weather data collected at the 15 Jornada Basin LTER CSIS study blocks, New Mexico. Measurements are aggregated at intervals of 5, 30, 60 minutes and daily, with precipitation additionally provided with 1 second aggregation during precipitation events. The met station variables measured include air temperature, precipitation, relative humidity, wind direction, wind speed. Precipitation is not measured at Block 1 and Block 12 because of proximity to Block 2 and Block 13, respectively . This is an ONGOING dataset.