cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.21335/nmdc-1473196070-168
title: CTD profile from 78.29933333333334 N, 15.025 E in Isfjorden, Svalbard, sampled at 31.10.2022, 23:07 UTC during the UNIS AGF311/811-cruise.

description: The file contains temperature, practical salinity and depth measurements binned into 1 db pressure bins. The raw data was measured at 78.29933333333334 N, 15.025 E at 31.10.2022, 23:07 UTC using a Seabird SBE9plus CTD and post-processed with the Seasoft software package. The following processing steps were applied (with default settings): 1. Data Conversion, 2. Wild Edit, 3. Align CTD, 4. Cell Thermal Mass, 5. Filter, 6. Bin Average. If not specified differently, the downcast of the profile was used.
DOI: 10.21335/nmdc-1473196070-169
title: CTD profile from 78.33316666666667 N, 14.8665 E in Isfjorden, Svalbard, sampled at 01.11.2022, 00:08 UTC during the UNIS AGF311/811-cruise.

description: The file contains temperature, practical salinity and depth measurements binned into 1 db pressure bins. The raw data was measured at 78.33316666666667 N, 14.8665 E at 01.11.2022, 00:08 UTC using a Seabird SBE9plus CTD and post-processed with the Seasoft software package. The following processing steps were applied (with default settings): 1. Data Conversion, 2. Wild Edit, 3. Align CTD, 4. Cell Thermal Mass, 5. Filter, 6. Bin Average. If not specified differently, the downcast of the profile was used.
DOI: 10.21335/nmdc-1473196070-170
title: CTD profile from 78.34266666666667 N, 14.818 E in Isfjorden, Svalbard, sampled at 01.11.2022, 00:38 UTC during the UNIS AGF311/811-cruise.

description: The file contains temperature, practical salinity and depth measurements binned into 1 db pressure bins. The raw data was measured at 78.34266666666667 N, 14.818 E at 01.11.2022, 00:38 UTC using a Seabird SBE9plus CTD and post-processed with the Seasoft software package. The following processing steps were applied (with default settings): 1. Data Conversion, 2. Wild Edit, 3. Align CTD, 4. Cell Thermal Mass, 5. Filter, 6. Bin Average. If not specified differently, the downcast of the profile was used.
DOI: 10.21335/nmdc-1473196070-171
title: CTD profile from 78.35166666666667 N, 14.777 E in Isfjorden, Svalbard, sampled at 01.11.2022, 01:07 UTC during the UNIS AGF311/811-cruise.

description: The file contains temperature, practical salinity and depth measurements binned into 1 db pressure bins. The raw data was measured at 78.35166666666667 N, 14.777 E at 01.11.2022, 01:07 UTC using a Seabird SBE9plus CTD and post-processed with the Seasoft software package. The following processing steps were applied (with default settings): 1. Data Conversion, 2. Wild Edit, 3. Align CTD, 4. Cell Thermal Mass, 5. Filter, 6. Bin Average. If not specified differently, the downcast of the profile was used.
DOI: 10.5281/zenodo.7461845
title: Data and materials for "The Consequences of Data Dispersion in Genomics: A Comparative Analysis of Data Sources for Precision Medicine" manuscript"

description: Data and sripts for the "The Consequences of Data Dispersion in Genomics: A Comparative Analysis of Data Sources for Precision Medicine" manuscript" manuscript, sent to BMC Bioinformatics
DOI: 10.5281/zenodo.7461844
title: Data and materials for "The Consequences of Data Dispersion in Genomics: A Comparative Analysis of Data Sources for Precision Medicine" manuscript"

description: Data and sripts for the "The Consequences of Data Dispersion in Genomics: A Comparative Analysis of Data Sources for Precision Medicine" manuscript" manuscript, sent to BMC Bioinformatics
DOI: 10.21335/nmdc-1473196070-e15
title: CTD profile from 78.556 N, 14.655 E in Isfjorden, Svalbard, sampled at 01.11.2022, 03:00 UTC during the UNIS AGF311/811-cruise.

description: The file contains temperature, practical salinity and depth measurements binned into 1 db pressure bins. The raw data was measured at 78.556 N, 14.655 E at 01.11.2022, 03:00 UTC using a Seabird SBE9plus CTD and post-processed with the Seasoft software package. The following processing steps were applied (with default settings): 1. Data Conversion, 2. Wild Edit, 3. Align CTD, 4. Cell Thermal Mass, 5. Filter, 6. Bin Average. If not specified differently, the downcast of the profile was used.
DOI: 10.21335/nmdc-1473196070-e16
title: CTD profile from 78.55983333333333 N, 14.7 E in Isfjorden, Svalbard, sampled at 01.11.2022, 03:25 UTC during the UNIS AGF311/811-cruise.

description: The file contains temperature, practical salinity and depth measurements binned into 1 db pressure bins. The raw data was measured at 78.55983333333333 N, 14.7 E at 01.11.2022, 03:25 UTC using a Seabird SBE9plus CTD and post-processed with the Seasoft software package. The following processing steps were applied (with default settings): 1. Data Conversion, 2. Wild Edit, 3. Align CTD, 4. Cell Thermal Mass, 5. Filter, 6. Bin Average. If not specified differently, the downcast of the profile was used.
DOI: 10.21335/nmdc-1473196070-e17
title: CTD profile from 78.5645 N, 14.75 E in Isfjorden, Svalbard, sampled at 01.11.2022, 03:48 UTC during the UNIS AGF311/811-cruise.

description: The file contains temperature, practical salinity and depth measurements binned into 1 db pressure bins. The raw data was measured at 78.5645 N, 14.75 E at 01.11.2022, 03:48 UTC using a Seabird SBE9plus CTD and post-processed with the Seasoft software package. The following processing steps were applied (with default settings): 1. Data Conversion, 2. Wild Edit, 3. Align CTD, 4. Cell Thermal Mass, 5. Filter, 6. Bin Average. If not specified differently, the downcast of the profile was used.
DOI: 10.21335/nmdc-1473196070-e18
title: CTD profile from 78.5685 N, 14.8085 E in Isfjorden, Svalbard, sampled at 01.11.2022, 04:13 UTC during the UNIS AGF311/811-cruise.

description: The file contains temperature, practical salinity and depth measurements binned into 1 db pressure bins. The raw data was measured at 78.5685 N, 14.8085 E at 01.11.2022, 04:13 UTC using a Seabird SBE9plus CTD and post-processed with the Seasoft software package. The following processing steps were applied (with default settings): 1. Data Conversion, 2. Wild Edit, 3. Align CTD, 4. Cell Thermal Mass, 5. Filter, 6. Bin Average. If not specified differently, the downcast of the profile was used.
DOI: 10.21335/nmdc-1473196070-e19
title: CTD profile from 78.57416666666667 N, 14.852833333333333 E in Isfjorden, Svalbard, sampled at 01.11.2022, 04:33 UTC during the UNIS AGF311/811-cruise.

description: The file contains temperature, practical salinity and depth measurements binned into 1 db pressure bins. The raw data was measured at 78.57416666666667 N, 14.852833333333333 E at 01.11.2022, 04:33 UTC using a Seabird SBE9plus CTD and post-processed with the Seasoft software package. The following processing steps were applied (with default settings): 1. Data Conversion, 2. Wild Edit, 3. Align CTD, 4. Cell Thermal Mass, 5. Filter, 6. Bin Average. If not specified differently, the downcast of the profile was used.
DOI: 10.5281/zenodo.6779121
title: Impact of Sacubitril/Valsartan on surfactant binding protein, central sleep apnea, lung function tests and heart failure biomarkers: hemodynamic or pleiotropism?

description: <strong>Purpose:</strong> Little is known about the mechanism underlying Sacubitril/Valsartan effects in patients with heart failure (HFrEF). Aim of the study is to assess hemodynamic vs. non-hemodynamic Sacubitril/Valsartan effects by analyzing several biological and functional parameters. <strong>Methods: </strong>Seventy-nine patients (86% males, age 66±10 years) were enrolled. At baseline and 6 months after reaching the maximum Sacubitril/Valsartan tolerated dose, we assessed biomarkers, transthoracic echocardiography, polysomnography, spirometry, and carbon monoxide diffusing capacity of the lung (DLCO). <strong>Results:</strong> Mean follow-up was 261±41 days with 83% of patients reaching Sacubitril/Valsartan maximum dose (97/103mg b.i.d). Significant improvements were observed in cardiac performance and biomarkers: left ventricular ejection fraction increased (31±5 vs. 37±9 %; p&lt;0.001), end-diastolic and end-systolic volumes decreased; NT-proBNP decreased (1196 [IQR 648-2891] vs. 958 [IQR 424-1663] pg/ml; p&lt;0.001) in parallel with interleukin ST-2 (28.4 [IQR 19.4-36.6] vs. 20.4 [IQR 15.1-29.2] ng/ml; p&lt;0.001) and circulating surfactant binding proteins (proSP-B: 58.43 [IQR 40.42-84.23] vs. 50.36 [IQR 37.16-69.54] AU; p=0.014 and SP-D: 102.17 [IQR 62.85-175.34] vs. 77.64 [IQR 53.55-144.70] AU; p&lt;0.001). Forced expiratory volume in 1 second and forced vital capacity improved. DLCO increased in the patients’ subgroup (n=39) with impaired baseline values (from 65.3±10.8 to 70.3±15.9 %predicted; p=0.013). We also observed a significant reduction in central sleep apneas (CSA). <strong>Conclusion</strong>: Sacubitril/Valsartan effects share a double pathway: hemodynamic and systemic. The first is evidenced by NT-proBNP, proSP-B, lung mechanics, and CSA improvement. The latter is confirmed by an amelioration of DLCO, ST-2, SP-D as well as by reverse remodeling echocardiographic parameters.
DOI: 10.5281/zenodo.6779120
title: Impact of Sacubitril/Valsartan on surfactant binding protein, central sleep apnea, lung function tests and heart failure biomarkers: hemodynamic or pleiotropism?

description: <strong>Purpose:</strong> Little is known about the mechanism underlying Sacubitril/Valsartan effects in patients with heart failure (HFrEF). Aim of the study is to assess hemodynamic vs. non-hemodynamic Sacubitril/Valsartan effects by analyzing several biological and functional parameters. <strong>Methods: </strong>Seventy-nine patients (86% males, age 66±10 years) were enrolled. At baseline and 6 months after reaching the maximum Sacubitril/Valsartan tolerated dose, we assessed biomarkers, transthoracic echocardiography, polysomnography, spirometry, and carbon monoxide diffusing capacity of the lung (DLCO). <strong>Results:</strong> Mean follow-up was 261±41 days with 83% of patients reaching Sacubitril/Valsartan maximum dose (97/103mg b.i.d). Significant improvements were observed in cardiac performance and biomarkers: left ventricular ejection fraction increased (31±5 vs. 37±9 %; p&lt;0.001), end-diastolic and end-systolic volumes decreased; NT-proBNP decreased (1196 [IQR 648-2891] vs. 958 [IQR 424-1663] pg/ml; p&lt;0.001) in parallel with interleukin ST-2 (28.4 [IQR 19.4-36.6] vs. 20.4 [IQR 15.1-29.2] ng/ml; p&lt;0.001) and circulating surfactant binding proteins (proSP-B: 58.43 [IQR 40.42-84.23] vs. 50.36 [IQR 37.16-69.54] AU; p=0.014 and SP-D: 102.17 [IQR 62.85-175.34] vs. 77.64 [IQR 53.55-144.70] AU; p&lt;0.001). Forced expiratory volume in 1 second and forced vital capacity improved. DLCO increased in the patients’ subgroup (n=39) with impaired baseline values (from 65.3±10.8 to 70.3±15.9 %predicted; p=0.013). We also observed a significant reduction in central sleep apneas (CSA). <strong>Conclusion</strong>: Sacubitril/Valsartan effects share a double pathway: hemodynamic and systemic. The first is evidenced by NT-proBNP, proSP-B, lung mechanics, and CSA improvement. The latter is confirmed by an amelioration of DLCO, ST-2, SP-D as well as by reverse remodeling echocardiographic parameters.
DOI: 10.21335/nmdc-1473196070-e20
title: CTD profile from 78.58083333333333 N, 14.903833333333333 E in Isfjorden, Svalbard, sampled at 01.11.2022, 04:53 UTC during the UNIS AGF311/811-cruise.

description: The file contains temperature, practical salinity and depth measurements binned into 1 db pressure bins. The raw data was measured at 78.58083333333333 N, 14.903833333333333 E at 01.11.2022, 04:53 UTC using a Seabird SBE9plus CTD and post-processed with the Seasoft software package. The following processing steps were applied (with default settings): 1. Data Conversion, 2. Wild Edit, 3. Align CTD, 4. Cell Thermal Mass, 5. Filter, 6. Bin Average. If not specified differently, the downcast of the profile was used.
DOI: 10.21335/nmdc-1473196070-e28
title: CTD profile from 78.5925 N, 14.814333333333334 E in Isfjorden, Svalbard, sampled at 01.11.2022, 05:27 UTC during the UNIS AGF311/811-cruise.

description: The file contains temperature, practical salinity and depth measurements binned into 1 db pressure bins. The raw data was measured at 78.5925 N, 14.814333333333334 E at 01.11.2022, 05:27 UTC using a Seabird SBE9plus CTD and post-processed with the Seasoft software package. The following processing steps were applied (with default settings): 1. Data Conversion, 2. Wild Edit, 3. Align CTD, 4. Cell Thermal Mass, 5. Filter, 6. Bin Average. If not specified differently, the downcast of the profile was used.
DOI: 10.21335/nmdc-1473196070-e30
title: CTD profile from 78.61383333333333 N, 14.706333333333333 E in Isfjorden, Svalbard, sampled at 01.11.2022, 06:03 UTC during the UNIS AGF311/811-cruise.

description: The file contains temperature, practical salinity and depth measurements binned into 1 db pressure bins. The raw data was measured at 78.61383333333333 N, 14.706333333333333 E at 01.11.2022, 06:03 UTC using a Seabird SBE9plus CTD and post-processed with the Seasoft software package. The following processing steps were applied (with default settings): 1. Data Conversion, 2. Wild Edit, 3. Align CTD, 4. Cell Thermal Mass, 5. Filter, 6. Bin Average. If not specified differently, the downcast of the profile was used.
DOI: 10.21335/nmdc-1473196070-e5
title: CTD profile from 78.63716666666667 N, 14.741833333333334 E in Isfjorden, Svalbard, sampled at 01.11.2022, 06:31 UTC during the UNIS AGF311/811-cruise.

description: The file contains temperature, practical salinity and depth measurements binned into 1 db pressure bins. The raw data was measured at 78.63716666666667 N, 14.741833333333334 E at 01.11.2022, 06:31 UTC using a Seabird SBE9plus CTD and post-processed with the Seasoft software package. The following processing steps were applied (with default settings): 1. Data Conversion, 2. Wild Edit, 3. Align CTD, 4. Cell Thermal Mass, 5. Filter, 6. Bin Average. If not specified differently, the downcast of the profile was used.
DOI: 10.21335/nmdc-1473196070-e4
title: CTD profile from 78.6375 N, 14.701666666666666 E in Isfjorden, Svalbard, sampled at 01.11.2022, 07:19 UTC during the UNIS AGF311/811-cruise.

description: The file contains temperature, practical salinity and depth measurements binned into 1 db pressure bins. The raw data was measured at 78.6375 N, 14.701666666666666 E at 01.11.2022, 07:19 UTC using a Seabird SBE9plus CTD and post-processed with the Seasoft software package. The following processing steps were applied (with default settings): 1. Data Conversion, 2. Wild Edit, 3. Align CTD, 4. Cell Thermal Mass, 5. Filter, 6. Bin Average. If not specified differently, the downcast of the profile was used.
DOI: 10.21335/nmdc-1473196070-e3
title: CTD profile from 78.6375 N, 14.681 E in Isfjorden, Svalbard, sampled at 01.11.2022, 07:34 UTC during the UNIS AGF311/811-cruise.

description: The file contains temperature, practical salinity and depth measurements binned into 1 db pressure bins. The raw data was measured at 78.6375 N, 14.681 E at 01.11.2022, 07:34 UTC using a Seabird SBE9plus CTD and post-processed with the Seasoft software package. The following processing steps were applied (with default settings): 1. Data Conversion, 2. Wild Edit, 3. Align CTD, 4. Cell Thermal Mass, 5. Filter, 6. Bin Average. If not specified differently, the downcast of the profile was used.
DOI: 10.21335/nmdc-1473196070-e2
title: CTD profile from 78.65033333333334 N, 14.675833333333333 E in Isfjorden, Svalbard, sampled at 01.11.2022, 08:08 UTC during the UNIS AGF311/811-cruise.

description: The file contains temperature, practical salinity and depth measurements binned into 1 db pressure bins. The raw data was measured at 78.65033333333334 N, 14.675833333333333 E at 01.11.2022, 08:08 UTC using a Seabird SBE9plus CTD and post-processed with the Seasoft software package. The following processing steps were applied (with default settings): 1. Data Conversion, 2. Wild Edit, 3. Align CTD, 4. Cell Thermal Mass, 5. Filter, 6. Bin Average. If not specified differently, the downcast of the profile was used.
DOI: 10.21335/nmdc-1473196070-e12
title: CTD profile from 78.661 N, 14.617666666666667 E in Isfjorden, Svalbard, sampled at 01.11.2022, 08:31 UTC during the UNIS AGF311/811-cruise.

description: The file contains temperature, practical salinity and depth measurements binned into 1 db pressure bins. The raw data was measured at 78.661 N, 14.617666666666667 E at 01.11.2022, 08:31 UTC using a Seabird SBE9plus CTD and post-processed with the Seasoft software package. The following processing steps were applied (with default settings): 1. Data Conversion, 2. Wild Edit, 3. Align CTD, 4. Cell Thermal Mass, 5. Filter, 6. Bin Average. If not specified differently, the downcast of the profile was used.
DOI: 10.21335/nmdc-1473196070-e11
title: CTD profile from 78.666 N, 14.561166666666667 E in Isfjorden, Svalbard, sampled at 01.11.2022, 08:58 UTC during the UNIS AGF311/811-cruise.

description: The file contains temperature, practical salinity and depth measurements binned into 1 db pressure bins. The raw data was measured at 78.666 N, 14.561166666666667 E at 01.11.2022, 08:58 UTC using a Seabird SBE9plus CTD and post-processed with the Seasoft software package. The following processing steps were applied (with default settings): 1. Data Conversion, 2. Wild Edit, 3. Align CTD, 4. Cell Thermal Mass, 5. Filter, 6. Bin Average. If not specified differently, the downcast of the profile was used.
DOI: 10.5281/zenodo.6405085
title: Dataset related to the article :"Mercaptoalbumin Is Associated with Graft Patency in Patients Undergoing Coronary Artery Bypass Grafting"

description: This record contains raw data related to the article:" Mercaptoalbumin Is Associated with Graft Patency in Patients Undergoing Coronary Artery Bypass Grafting" Abstract Coronary artery bypass graft (CABG) surgery still represents the gold standard for patients with complex multivessel coronary artery disease. However, graft occlusion still occurs in a significant proportion of CABG conduits, and oxidative stress is currently considered to be a potential contributor. Human serum albumin (HSA) represents the main antioxidant in plasma through its reduced amino acid Cys34, which can efficiently scavenge several oxidants.<strong> </strong>In a nested case–control study including 36 patients with occluded grafts and 38 age- and sex-matched patients without occlusion, we assessed the levels of the native mercaptoalbumin (HSA-SH) and oxidized thiolated form of albumin (Thio-HSA) in relation with graft occlusion within 5 years after CABG.<strong> </strong>We found that the plasma level of preoperative HSA-SH was significantly lower in patients with occluded graft at 5 years follow-up than in patients with graft patency. Furthermore, low HSA-SH remained independently associated with graft occlusion even after adjusting for preoperative D-dimer, a well-known marker of activated coagulation recently found to be associated with graft occlusion. In conclusion, the preoperative level of HSA-SH is independently associated with graft occlusion in CABG and represents a measurable and potentially druggable predictor.
description: This work was supported by the Italian Ministry of Health, Rome, Italy (Ricerca Corrente 278 RC 2019 MPP1A ID 2755301).
DOI: 10.5281/zenodo.6405086
title: Dataset related to the article :"Mercaptoalbumin Is Associated with Graft Patency in Patients Undergoing Coronary Artery Bypass Grafting"

description: This record contains raw data related to the article:" Mercaptoalbumin Is Associated with Graft Patency in Patients Undergoing Coronary Artery Bypass Grafting" Abstract Coronary artery bypass graft (CABG) surgery still represents the gold standard for patients with complex multivessel coronary artery disease. However, graft occlusion still occurs in a significant proportion of CABG conduits, and oxidative stress is currently considered to be a potential contributor. Human serum albumin (HSA) represents the main antioxidant in plasma through its reduced amino acid Cys34, which can efficiently scavenge several oxidants.<strong> </strong>In a nested case–control study including 36 patients with occluded grafts and 38 age- and sex-matched patients without occlusion, we assessed the levels of the native mercaptoalbumin (HSA-SH) and oxidized thiolated form of albumin (Thio-HSA) in relation with graft occlusion within 5 years after CABG.<strong> </strong>We found that the plasma level of preoperative HSA-SH was significantly lower in patients with occluded graft at 5 years follow-up than in patients with graft patency. Furthermore, low HSA-SH remained independently associated with graft occlusion even after adjusting for preoperative D-dimer, a well-known marker of activated coagulation recently found to be associated with graft occlusion. In conclusion, the preoperative level of HSA-SH is independently associated with graft occlusion in CABG and represents a measurable and potentially druggable predictor.
description: This work was supported by the Italian Ministry of Health, Rome, Italy (Ricerca Corrente 278 RC 2019 MPP1A ID 2755301).
DOI: 10.21335/nmdc-1473196070-e01
title: CTD profile from 78.676 N, 14.5645 E in Isfjorden, Svalbard, sampled at 01.11.2022, 09:17 UTC during the UNIS AGF311/811-cruise.

description: The file contains temperature, practical salinity and depth measurements binned into 1 db pressure bins. The raw data was measured at 78.676 N, 14.5645 E at 01.11.2022, 09:17 UTC using a Seabird SBE9plus CTD and post-processed with the Seasoft software package. The following processing steps were applied (with default settings): 1. Data Conversion, 2. Wild Edit, 3. Align CTD, 4. Cell Thermal Mass, 5. Filter, 6. Bin Average. If not specified differently, the downcast of the profile was used.
DOI: 10.21335/nmdc-1473196070-e01_1
title: CTD profile from 78.676 N, 14.5645 E in Isfjorden, Svalbard, sampled at 01.11.2022, 12:15 UTC during the UNIS AGF311/811-cruise.

description: The file contains temperature, practical salinity and depth measurements binned into 1 db pressure bins. The raw data was measured at 78.676 N, 14.5645 E at 01.11.2022, 12:15 UTC using a Seabird SBE9plus CTD and post-processed with the Seasoft software package. The following processing steps were applied (with default settings): 1. Data Conversion, 2. Wild Edit, 3. Align CTD, 4. Cell Thermal Mass, 5. Filter, 6. Bin Average. If not specified differently, the downcast of the profile was used.
DOI: 10.21335/nmdc-1473196070-e4_1
title: CTD profile from 78.6375 N, 14.699833333333334 E in Isfjorden, Svalbard, sampled at 01.11.2022, 13:09 UTC during the UNIS AGF311/811-cruise.

description: The file contains temperature, practical salinity and depth measurements binned into 1 db pressure bins. The raw data was measured at 78.6375 N, 14.699833333333334 E at 01.11.2022, 13:09 UTC using a Seabird SBE9plus CTD and post-processed with the Seasoft software package. The following processing steps were applied (with default settings): 1. Data Conversion, 2. Wild Edit, 3. Align CTD, 4. Cell Thermal Mass, 5. Filter, 6. Bin Average. If not specified differently, the downcast of the profile was used.
DOI: 10.21335/nmdc-1473196070-e27
title: CTD profile from 78.62266666666666 N, 14.654666666666667 E in Isfjorden, Svalbard, sampled at 01.11.2022, 13:34 UTC during the UNIS AGF311/811-cruise.

description: The file contains temperature, practical salinity and depth measurements binned into 1 db pressure bins. The raw data was measured at 78.62266666666666 N, 14.654666666666667 E at 01.11.2022, 13:34 UTC using a Seabird SBE9plus CTD and post-processed with the Seasoft software package. The following processing steps were applied (with default settings): 1. Data Conversion, 2. Wild Edit, 3. Align CTD, 4. Cell Thermal Mass, 5. Filter, 6. Bin Average. If not specified differently, the downcast of the profile was used.