cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.1314131.v6
title: Single-cell analysis challenges the connection between autophagy and senescence induced by DNA damage

description: Autophagy and senescence have been described as central features of cell biology, but the interplay between these mechanisms remains obscure. Using a therapeutically relevant model of DNA damage-induced senescence in human glioma cells, we demonstrated that acute treatment with temozolomide induces DNA damage, a transitory activation of PRKAA/AMPK-ULK1 and MAPK14/p38 and the sustained inhibition of AKT-MTOR. This produced a transient induction of autophagy, which was followed by senescence. However, at the single cell level, this coordinated transition was not observed, and autophagy and senescence were triggered in a very heterogeneous manner. Indeed, at a population level, autophagy was highly negatively correlated with senescence markers, while in single cells this correlation did not exist. The inhibition of autophagy triggered apoptosis and decreased senescence, while its activation increased temozolomide-induced senescence, showing that DNA damage-induced autophagy acts by suppressing apoptosis.
DOI: 10.6084/m9.figshare.1313835
title: #MikeBrown.12.1-12.4.xlsx

description: Twitter data on #MikeBrown. See Project Descritpion for details.
DOI: 10.6084/m9.figshare.1313875.v1
title: #MikeBrown12.4-12.6.xlsx

description: Twitter data on #MikeBrown. See Project Descritpion for details.
DOI: 10.6084/m9.figshare.1313905.v1
title: #MikeBrown.12.6-12.10.xlsx

description: Twitter data on #MikeBrown. See Project Descritpion for details.
DOI: 10.6084/m9.figshare.1313762
title: #MikeBrown.11.25-11.27.xlsx

description: Twitter data on #MikeBrown. See Project Descritpion for details.
DOI: 10.6084/m9.figshare.1313778
title: #MikeBrown.11.27-12.1.xlsx

description: Twitter data on #MikeBrown. See Project Descritpion for details.
DOI: 10.6084/m9.figshare.1313835.v1
title: #MikeBrown.12.1-12.4.xlsx

description: Twitter data on #MikeBrown. See Project Descritpion for details.
DOI: 10.6084/m9.figshare.1314102.v3
title: 12 January 2015 Field Notes

description: Field notes including image and/or video records. Original versions of all videos are available as of 20 Jan 2016 following the increase in allowed file size by figshare.
DOI: 10.6084/m9.figshare.1314131.v7
title: Single-cell analysis challenges the connection between autophagy and senescence induced by DNA damage

description: Autophagy and senescence have been described as central features of cell biology, but the interplay between these mechanisms remains obscure. Using a therapeutically relevant model of DNA damage-induced senescence in human glioma cells, we demonstrated that acute treatment with temozolomide induces DNA damage, a transitory activation of PRKAA/AMPK-ULK1 and MAPK14/p38 and the sustained inhibition of AKT-MTOR. This produced a transient induction of autophagy, which was followed by senescence. However, at the single cell level, this coordinated transition was not observed, and autophagy and senescence were triggered in a very heterogeneous manner. Indeed, at a population level, autophagy was highly negatively correlated with senescence markers, while in single cells this correlation did not exist. The inhibition of autophagy triggered apoptosis and decreased senescence, while its activation increased temozolomide-induced senescence, showing that DNA damage-induced autophagy acts by suppressing apoptosis.
DOI: 10.6084/m9.figshare.1313778.v1
title: #MikeBrown.11.27-12.1.xlsx

description: Twitter data on #MikeBrown. See Project Descritpion for details.
DOI: 10.6084/m9.figshare.1313728
title: 2015 01 03 Comparison Sequence for 2014 07 01-02 Time-Lapse Sequence

description: 3 January 2015 - Complete sequence of Reconyx HC600 HyperFire trail camera images using both the motion sensor and time-lapse to trigger the camera. Attempted comparison shoot of a human subject and an 11" x 17" target placed close to the location at which an unknown animal is visible in image 6891 obtained on 1-2 July 2014. The camera is placed in the same location (just below a fork in the tree) on the same tree. The camera orientation is not accurately reproduced and the target is out of view beyond the left edge of the camera field of view.<br>Project order 52a<br>
DOI: 10.6084/m9.figshare.1313730
title: 2015 01 03 Comparison Sequence for 2014 06 27-28 Images

description: 3 January 2015 - Complete sequence of Reconyx HC600 HyperFire trail camera images using both the motion sensor and time-lapse to trigger the camera. Comparison shoot of human subjects placed in the locations at which unknown animals are observed in images 370, 386, 458, and 459 obtained on 27-28 June 2014. The camera is placed in the same location (a large knob) on the same tree.<br>Project order 53a<br>
DOI: 10.6084/m9.figshare.1313762.v1
title: #MikeBrown.11.25-11.27.xlsx

description: Twitter data on #MikeBrown. See Project Descritpion for details.
DOI: 10.6084/m9.figshare.1313734.v1
title: 3 January 2015 Field Notes

description: Field notes including image and/or video records.
DOI: 10.6084/m9.figshare.1313728.v2
title: 2015 01 03 Comparison Sequence for 2014 07 01-02 Time-Lapse Sequence

description: 3 January 2015 - Complete sequence of Reconyx HC600 HyperFire trail camera images using both the motion sensor and time-lapse to trigger the camera. Attempted comparison shoot of a human subject and an 11" x 17" target placed close to the location at which an unknown animal is visible in image 6891 obtained on 1-2 July 2014. The camera is placed in the same location (just below a fork in the tree) on the same tree. The camera orientation is not accurately reproduced and the target is out of view beyond the left edge of the camera field of view.<br>Project order 52a<br>
DOI: 10.6084/m9.figshare.1313730.v2
title: 2015 01 03 Comparison Sequence for 2014 06 27-28 Images

description: 3 January 2015 - Complete sequence of Reconyx HC600 HyperFire trail camera images using both the motion sensor and time-lapse to trigger the camera. Comparison shoot of human subjects placed in the locations at which unknown animals are observed in images 370, 386, 458, and 459 obtained on 27-28 June 2014. The camera is placed in the same location (a large knob) on the same tree.<br>Project order 53a<br>
DOI: 10.6084/m9.figshare.1313734.v2
title: 3 January 2015 Field Notes

description: Field notes including image and/or video records. Original versions of all videos are available as of 20 Jan 2016 following the increase in allowed file size by figshare.
DOI: 10.6084/m9.figshare.1313728.v1
title: 3 January 2015 Comparison Sequence for 1-2 July 2014 Time-Lapse Sequence

description: 3 January 2015 - Complete sequence of Reconyx HC600 HyperFire trail camera images using both the motion sensor and time-lapse to trigger the camera. Attempted comparison shoot of a human subject and an 11" x 17" target placed close to the location at which an unknown animal is visible in image 6891 obtained on 1-2 July 2014. The camera is placed in the same location (just below a fork in the tree) on the same tree. The camera orientation is not accurately reproduced and the target is out of view beyond the left edge of the camera field of view.
DOI: 10.6084/m9.figshare.1313730.v1
title: 3 January 2015 Comparison Sequence for 27-28 June 2014 Images

description: 3 January 2015 - Complete sequence of Reconyx HC600 HyperFire trail camera images using both the motion sensor and time-lapse to trigger the camera. Comparison shoot of human subjects placed in the locations at which unknown animals are observed in images 370, 386, 458, and 459 obtained on 27-28 June 2014. The camera is placed in the same location (a large knob) on the same tree.
DOI: 10.6084/m9.figshare.1313705
title: Shifts in Symbiotic Endophyte Communities of a Foundational Salt Marsh Grass Following Oil Exposure From the Deepwater Horizon Oil Spill

description: Dataset for PLOSone paper
DOI: 10.6084/m9.figshare.1313691
title: Raw data at different imaging conditions

description: Raw data of single-molecule super-resolution imaging of Alexa Flour 647-immunolabeled microtubules at different imaging conditions.
DOI: 10.6084/m9.figshare.1313697
title: The Last Line Effect -- Erors in Micro-Clones

description: A dataset containing all errors in micro-clones generated by the PVS-Studio tool, and our statistical analyses on them.
DOI: 10.6084/m9.figshare.1313705.v1
title: Shifts in Symbiotic Endophyte Communities of a Foundational Salt Marsh Grass Following Oil Exposure From the Deepwater Horizon Oil Spill

description: Dataset for PLOSone paper
DOI: 10.6084/m9.figshare.1313691.v1
title: Quantifying_SMS_Alexa647

description: Raw data of single-molecule super-resolution imaging of Alexa Flour 647-immunolabeled microtubules at different imaging conditions (laser intensity and camera frame rate).
DOI: 10.6084/m9.figshare.1313697.v1
title: The Last Line Effect -- Erors in Micro-Clones

description: A dataset containing all errors in micro-clones generated by the PVS-Studio tool, and our statistical analysis on them.
DOI: 10.6084/m9.figshare.1313691.v2
title: Quantifying_SMS_Alexa647

description: Raw data of single-molecule super-resolution imaging of Alexa Flour 647-immunolabeled microtubules at different imaging conditions (laser intensity and camera frame rate).
DOI: 10.6084/m9.figshare.1313697.v2
title: The Last Line Effect -- Erors in Micro-Clones

description: A dataset containing all errors in micro-clones generated by the PVS-Studio tool, and our statistical analysis on them.
DOI: 10.6084/m9.figshare.1313688.v1
title: Place-based Citizen Science: Linking Together to Leverage the Power of Place

description: Presented At AAAS 2015, and during the open format session at the inaugural confernce of the Citizen Science Association
DOI: 10.6084/m9.figshare.1313697.v3
title: The Last Line Effect -- Erors in Micro-Clones

description: A dataset containing all errors in micro-clones generated by the PVS-Studio tool, and our statistical analysis on them.
DOI: 10.6084/m9.figshare.1313672
title: Malyshev et al PONE

description: Data for the paper: Advantages and limitations of the use of optogenetic approach in studying fast-scale spike encoding Aleksey Malyshev, Roman Goz, Joseph J. LoTurco, Maxim Volgushev PLos ONE 2015
DOI: 10.6084/m9.figshare.1313688.v2
title: Place-based Citizen Science: Linking Together to Leverage the Power of Place. American Association for the Advancement of Science, San Jose, CA. Feb. 15, 2015.

description: Presented At AAAS 2015, and during the open format session at the inaugural confernce of the Citizen Science Association
DOI: 10.6084/m9.figshare.1313665
title: Gaussian Job Archive for C14H12O2

description: Archive of work produced using the resources of the Imperial College High Performance Computing Service.
DOI: 10.6084/m9.figshare.1313672.v1
title: Malyshev et al PONE

description: Data for the paper: Advantages and limitations of the use of optogenetic approach in studying fast-scale spike encoding Aleksey Malyshev, Roman Goz, Joseph J. LoTurco, Maxim Volgushev PLos ONE 2015
DOI: 10.6084/m9.figshare.1313688.v3
title: Place-based Citizen Science: Linking Together to Leverage the Power of Place. American Association for the Advancement of Science, San Jose, CA. Feb. 15, 2015

description: Presented At AAAS 2015, and during the open format session at the inaugural confernce of the Citizen Science Association
DOI: 10.6084/m9.figshare.1313665.v1
title: Gaussian Job Archive for C14H12O2

description: Archive of work produced using the resources of the Imperial College High Performance Computing Service.
DOI: 10.6084/m9.figshare.1313645
title: Figure 4 Highly effective fibrinolysis by a sequential synergistic combination of mini-dose tPA plus low-dose mutant proUK

description: Fig 4. Lytic effect of range of tPA doses in presence of fixed low-dose M5
DOI: 10.6084/m9.figshare.1313644
title: Figure 1 Highly effective fibrinolysis by a sequential synergistic combination of mini-dose tPA plus low-dose mutant proUK

description: Fig 1. Maximum dose lysis
DOI: 10.6084/m9.figshare.1313645.v1
title: Figure 4

description: Fig 4. Lytic effect of range of tPA doses in presence of fixed low-dose M5
DOI: 10.6084/m9.figshare.1313643
title: Figure 2 Highly effective fibrinolysis by a sequential synergistic combination of mini-dose tPA plus low-dose mutant proUK

description: Fig 2. Effect of C1-inibitor
DOI: 10.6084/m9.figshare.1313642
title: Figure 6 Highly effective fibrinolysis by a sequential synergistic combination of mini-dose tPA plus low-dose mutant proUK

description: Fig 6. The effect of the synergistic dose combination in plasma alone
DOI: 10.6084/m9.figshare.1313645.v3
title: Figure 4 Highly effective fibrinolysis by a sequential synergistic combination of mini-dose tPA plus low-dose mutant proUK

description: Fig 4. Lytic effect of range of tPA doses in presence of fixed low-dose M5
DOI: 10.6084/m9.figshare.1313641
title: Figure 3 Highly effective fibrinolysis by a sequential synergistic combination of mini-dose tPA plus low-dose mutant proUK

description: Fig 3. The synergistic combination
DOI: 10.6084/m9.figshare.1313644.v1
title: Figure 1

description: Fig 1. Maximum dose lysis
DOI: 10.6084/m9.figshare.1313645.v2
title: Highly effective fibrinolysis by a sequential synergistic combination of mini-dose tPA plus low-dose mutant proUK Figure 4

description: Fig 4. Lytic effect of range of tPA doses in presence of fixed low-dose M5
DOI: 10.6084/m9.figshare.1313640
title: Figure 5 Highly effective fibrinolysis by a sequential synergistic combination of mini-dose tPA plus low-dose mutant proUK

description: Fig 5. Lysis times from all the groups tested
DOI: 10.6084/m9.figshare.1313644.v3
title: Figure 1 Highly effective fibrinolysis by a sequential synergistic combination of mini-dose tPA plus low-dose mutant proUK

description: Fig 1. Maximum dose lysis
DOI: 10.6084/m9.figshare.1313641.v1
title: Figure 3

description: Fig 3. The synergistic combination
DOI: 10.6084/m9.figshare.1313642.v1
title: Figure 6

description: Fig 6. The effect of the synergistic dose combination in plasma alone
DOI: 10.6084/m9.figshare.1313644.v2
title: Highly effective fibrinolysis by a sequential synergistic combination of mini-dose tPA plus low-dose mutant proUK Figure 1

description: Fig 1. Maximum dose lysis
DOI: 10.6084/m9.figshare.1313643.v1
title: Figure 2

description: Fig 2. Effect of C1-inibitor
DOI: 10.6084/m9.figshare.1313641.v3
title: Figure 3 Highly effective fibrinolysis by a sequential synergistic combination of mini-dose tPA plus low-dose mutant proUK

description: Fig 3. The synergistic combination
DOI: 10.6084/m9.figshare.1313639
title: Raw data notes - Highly effective fibrinolysis by a sequential synergistic combination of mini-dose tPA plus low-dose mutant proUK

description: Notes on the data
DOI: 10.6084/m9.figshare.1313641.v2
title: Highly effective fibrinolysis by a sequential synergistic combination of mini-dose tPA plus low-dose mutant proUK Figure 3

description: Fig 3. The synergistic combination
DOI: 10.6084/m9.figshare.1313640.v1
title: Figure 5

description: Fig 5. Lysis times from all the groups tested
DOI: 10.6084/m9.figshare.1313642.v2
title: Highly effective fibrinolysis by a sequential synergistic combination of mini-dose tPA plus low-dose mutant proUK Figure 6

description: Fig 6. The effect of the synergistic dose combination in plasma alone
DOI: 10.6084/m9.figshare.1313643.v2
title: Highly effective fibrinolysis by a sequential synergistic combination of mini-dose tPA plus low-dose mutant proUK Figure 2

description: Fig 2. Effect of C1-inibitor
DOI: 10.6084/m9.figshare.1313640.v3
title: Figure 5 Highly effective fibrinolysis by a sequential synergistic combination of mini-dose tPA plus low-dose mutant proUK

description: Fig 5. Lysis times from all the groups tested
DOI: 10.6084/m9.figshare.1313640.v2
title: Highly effective fibrinolysis by a sequential synergistic combination of mini-dose tPA plus low-dose mutant proUK Figure 5

description: Fig 5. Lysis times from all the groups tested
DOI: 10.6084/m9.figshare.1313639.v1
title: Notes

description: Notes on the data
DOI: 10.6084/m9.figshare.1313639.v3
title: Raw data notes - Highly effective fibrinolysis by a sequential synergistic combination of mini-dose tPA plus low-dose mutant proUK

description: Notes on the data
DOI: 10.6084/m9.figshare.1313639.v2
title: Highly effective fibrinolysis by a sequential synergistic combination of mini-dose tPA plus low-dose mutant proUK - Raw data notes

description: Notes on the data
DOI: 10.6084/m9.figshare.1313598
title: Gene Annoation

description: This data is a SNP to gene annotation created based on the Ensembl Genes database (Release 73, UMD3.1) for the 231057 SNPs in the Genotypes.RData dataset.
DOI: 10.6084/m9.figshare.1313596
title: Genotype Data of 282 dairy cows

description: This RData contains the genotype matrix "geno" with genotypes coded as 0,1,2 for 281 dairy cows after quality control and filtering. This dataset contains only 231057 SNP that are annotated to at least one gene according to the Gene-Annotation created with Ensmbl.
DOI: 10.6084/m9.figshare.1313597
title: NEFA, BHBA and glucose measurements

description: This table contains the NEFA, BHBA and glucose measurements for ~250 dairy cows before and after calving.
DOI: 10.6084/m9.figshare.1313596.v1
title: Genotype Data of 282 dairy cows

description: This RData contains the genotype matrix "geno" with genotypes coded as 0,1,2 for 281 dairy cows after quality control and filtering. This dataset contains only 231057 SNP that are annotated to at least one gene according to the Gene-Annotation created with Ensmbl.
DOI: 10.6084/m9.figshare.1313598.v1
title: Gene Annoation

description: This data is a SNP to gene annotation created based on the Ensembl Genes database (Release 73, UMD3.1) for the 231057 SNPs in the Genotypes.RData dataset.
DOI: 10.6084/m9.figshare.1313587
title: Gaussian Job Archive for C8H12

description: Archive of work produced using the resources of the Imperial College High Performance Computing Service.
DOI: 10.6084/m9.figshare.1313590
title: Gaussian Job Archive for C6H8O2

description: Archive of work produced using the resources of the Imperial College High Performance Computing Service.
DOI: 10.6084/m9.figshare.1313587.v1
title: Gaussian Job Archive for C8H12

description: Archive of work produced using the resources of the Imperial College High Performance Computing Service.
DOI: 10.6084/m9.figshare.1313590.v1
title: Gaussian Job Archive for C6H8O2

description: Archive of work produced using the resources of the Imperial College High Performance Computing Service.
DOI: 10.6084/m9.figshare.1313519
title: Domain knowledge base

description: domian patterns
DOI: 10.6084/m9.figshare.1313519.v2
title: Domain knowledge base

description: domian patterns
DOI: 10.6084/m9.figshare.1313519.v1
title: Domain knowledge base

description: a knowledge base of known effects and side effects of drugs, was collected from www.dailymed.com and www.webmd.com websites
DOI: 10.6084/m9.figshare.1313000
title: Jaw mechanics and evolutionary paleoecology of the megaherbivorous dinosaurs from the Dinosaur Park Formation (upper Campanian) of Alberta, Canada

description: ABSTRACTThe question of what role differential jaw mechanics may have played in facilitating dietary niche partitioning among Late Cretaceous megaherbivorous dinosaurs from Laramidia is examined, using the fossil assemblage of the Dinosaur Park Formation as a test case. We use phylogenetic inference to reconstruct the mandibular adductor musculature of these animals, which we then apply to the construction of biomechanical lever models of the mandible to estimate relative bite forces. Our findings reveal predictably weak bite forces in ankylosaurs, and comparatively high bite forces in ceratopsids and hadrosaurids, both of which possessed a mechanical advantage that produced bite forces 2–3 times higher than those forces exerted by the adductor musculature. The impressive jaw mechanism shared by the last two taxa evolved in a stepwise fashion, independently in each lineage. There is tentative evidence to suggest that nodosaurids had more powerful bites than ankylosaurids, but the overall mechanical diversity among megaherbivores from the Dinosaur Park Formation is low, suggesting that differential jaw mechanics could have played only a subsidiary role in niche partitioning. Such mechanical conservatism may have may have been selected for, or it may simply reflect the limits imposed by evolutionary constraints. Regardless, mechanical disparity patterns remained stable throughout the ∼1.5 Ma evolution of the Dinosaur Park Formation megaherbivore chronofauna.SUPPLEMENTAL DATA—Supplemental materials are available for this article for free at www.tandfonline.com/UJVP
DOI: 10.6084/m9.figshare.1313001
title: A new metriorhynchoid (Crocodylomorpha, Thalattosuchia) from the Middle Jurassic of Oregon and the evolutionary timing of marine adaptations in thalattosuchian crocodylomorphs

description: ABSTRACTMetriorhynchid thalattosuchians represent the most extreme archosaurian adaptation to the marine realm. Metriorhynchids possess aquatic adaptations throughout the skeleton. These adaptations were so extensive that some have suggested that they lost the ability to move on land, yet their evolutionary timing remains unresolved. The closest relatives of the metriorhynchoids, the teleosauroids, lack these aquatic adaptations, and the earliest metriorhynchoids are known exclusively from cranial material. Here I describe a partial skull with associated forelimb elements of a new marine crocodylomorph, <i>Zoneait nargorum</i>, gen. et sp. nov., of Aalenian–Bajocian age from the Snowshoe Formation of east-central Oregon. Phylogenetic analysis identifies <i>Zoneait</i> as the sister taxon to Metriorhynchidae. It possesses a derived skull with orbits that are more laterally directed and prefrontals that are more expanded than in other basal metriorhynchoids. The preserved forelimb elements are less derived. The humerus is elongate in comparison with that of other metriorhynchoids. The ulna is slightly reduced in length and flattened but resembles the teleosauroid condition more so than the plate-like element of metriorhynchids. This suggests that marine adaptations in metriorhynchoids were acquired in mosaic fashion, with modifications of the skull preceding forelimb reduction, with this forelimb reduction occurring first in the zeugopodial elements, prior to reduction of the humerus. This evolutionary timing has important implications for the transition from nearshore ambush predation to pelagic open-marine predation in Thalattosuchia, suggesting that adaptations related to prey detection and capture preceded the locomotor adaptations that allowed these organisms to fully invade the oceans.http://zoobank.org/urn:lsid:zoobank.org:pub:407671AC-E785-4831-9FB3-560965F15A2ESUPPLEMENTAL DATA—Supplemental materials are available for this article for free at www.tandfonline.com/UJVP
DOI: 10.6084/m9.figshare.1313016.v3
title: 22 December 2014 Field Notes

description: Field notes including image and/or video records.