cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.5835936.v3
title: Trading Imbalance in Chinese Stock Market - A High-Frequency View

description: 1. The series of files named as ‘*_polarity.csv’ in folder ‘polarity’ includes the trading polarities of stocks listed on Shenzhen Stock Exchange from May 4 to July 31 2015. The eight numbers in the filenames specify the dates. The columns of these dataframes indicate the stock names, while the indices of dataframes indicate the time. The granularity of trading polarity is 1 minute for every stock. These trading polarities are calculated from the serial numbers for buyers and sellers in transactions data. The original transactions data is not publicly available due to the company’s license requirement.<br>2. The files in the 'log_ret' folder cover the log returns of 1646 stocks listed on Shenzhen Stock Exchange from May 4 to July 31 2015. These data are calculated from the intraday price trends data provided by Thomson Reuters’ Tick History. The original price trends data is not publicly available due to the company’s license requirement.<br>3. The file named as "stock_market_value.csv" gives the capitalization of stocks in June 31 2015, which is downloaded from Wind Information and we have converted the unit of measure from RMB into a dollar. Due to license requirements of the data companies, all of the above files have converted the names of stocks into integers in a consistent way. <br>4. Please cite the following paper:<br>Shan Lu, Jichang Zhao and Huiwen Wang. Trading Imbalance in Chinese Stock Market—A High-Frequency View. Entropy, 2020, 22(8), 897.<br>
DOI: 10.6084/m9.figshare.5835798
title: Modeling damage propagation with G/XFEM in concrete structures: computational aspects and numerical investigations - supporting materials

description: The additional files to solve 2D solid mechanics problems using an OOP-based in-house code, called INSANE.<br>This files helps to reproduce the results shown in the paper: <b>Modeling damage propagation with G/XFEM in concrete structures: computational aspects and numerical investigations - supporting materials</b>. Computers and Concrete (under review), 2018.
DOI: 10.6084/m9.figshare.5835798.v1
title: Computational Framework for Nonlinear Analysis: a Comparison of G/XFEM versus FEM Approaches - supporting materials

description: The additional files to solve 2D solid mechanics problems using an OOP-based in-house code, called INSANE.<br>This files helps to reproduce the results shown in the paper: <b>Computational Framework for Nonlinear Analysis: a Comparison of G/XFEM versus FEM Approaches - supporting materials</b>. Computers and Structures (under review), 2018.
DOI: 10.6084/m9.figshare.5835798.v2
title: Computational Framework for Nonlinear Analysis: a Comparison of G/XFEM versus FEM Approaches - supporting materials

description: The additional files to solve 2D solid mechanics problems using an OOP-based in-house code, called INSANE.<br>This files helps to reproduce the results shown in the paper: <b>Computational Framework for Nonlinear Analysis: a Comparison of G/XFEM versus FEM Approaches - supporting materials</b>. Computers and Structures (under review), 2018.
DOI: 10.6084/m9.figshare.5835798.v3
title: Modeling damage propagation with G/XFEM in concrete structures: computational aspects and numerical investigations - supporting materials

description: The additional files to solve 2D solid mechanics problems using an OOP-based in-house code, called INSANE.<br>This files helps to reproduce the results shown in the paper: <b>Modeling damage propagation with G/XFEM in concrete structures: computational aspects and numerical investigations - supporting materials</b>. Computers and Concrete (under review), 2018.
DOI: 10.6084/m9.figshare.5835798.v5
title: Modeling damage propagation with G/XFEM in concrete structures: computational aspects and numerical investigations - supporting materials

description: The additional files to solve 2D solid mechanics problems using an OOP-based in-house code, called INSANE.<br>This files helps to reproduce the results shown in the paper: <b>Modeling damage propagation with G/XFEM in concrete structures: computational aspects and numerical investigations - supporting materials</b>. Computers and Concrete (under review), 2018.
DOI: 10.6084/m9.figshare.5835798.v4
title: Modeling damage propagation with G/XFEM in concrete structures: computational aspects and numerical investigations - supporting materials

description: The additional files to solve 2D solid mechanics problems using an OOP-based in-house code, called INSANE.<br>This files helps to reproduce the results shown in the paper: <b>Modeling damage propagation with G/XFEM in concrete structures: computational aspects and numerical investigations - supporting materials</b>. Computers and Concrete (under review), 2018.
DOI: 10.6084/m9.figshare.5835786
title: Dataset for: P2X7 receptor antagonism ameliorates renal dysfunction in a rat model of sepsis

description: Sepsis is a major clinical problem associated with significant organ dysfunction and high mortality. The ATP-sensitive P2X7 receptor activates the NLRP3 inflammasome is a key component of the innate immune system. We used a fluid-resuscitated rat model of fecal peritonitis and acute kidney injury (AKI) to investigate the contribution of this purinergic receptor to renal dysfunction in sepsis. Six and 24 hour time-points were chosen to represent early and established sepsis, respectively. A selective P2X7 receptor antagonist (A-438079) dissolved in dimethyl sulfoxide (DMSO) was infused 2h following induction of sepsis. Compared with sham-operated animals, septic animals had significant increases in heart rate (-1(-4–8)% vs. 21(12-26)%; p=0.003)), fever (37.4(37.2-37.6)oC vs. 38.6(38.2-39.0)oC; p=0.0009), and falls in serum albumin (29(27-30)g/l vs. 26(24-28); p=0.0242). Serum IL-1 (0(0-10)(pg/ml) vs. 1671(1445-33778)(pg/ml); p&lt;0.001) and renal IL-1 (86(50-102)pg/mg protein vs. 200 (147-248)pg/mg protein; p=0.0031) were significantly elevated in septic compared with sham-operated animals at 6h. Serum creatinine was elevated in septic animals compared with sham-operated animals at 24h (23(22-25)mol/l vs. 28 (25-30)mol/l; p=0.0321). Renal IL-1 levels were significantly lower in A-438079-treated animals compared with untreated animals at 6h (70(5-128)pg/mg protein vs. 200(147-248)pg/mg protein; p=0.021). At 24h, compared with untreated animals, A-438079-treated animals had more rapid resolution of tachycardia (22(13-36)% vs. -1(-6-7)%; p=0.019) and fever (39.0(38.6-39.1)oC vs. 38.2(37.6-38.7)oC; p&lt;0.024), higher serum albumin (23(21-25)g/l vs. (27(25-28)g/l); p=0.006), lower arterial lactate (3.2(2.5-4.3)mmol/l vs.1.4(0.9-1.8)mmol/l; p=0.037), and lower serum creatinine concentrations (28(25-30)mol/l vs.22(17-27)mol/l; p=0.019). P2X7A treatment ameliorates the systemic inflammatory response and renal dysfunction in this clinically relevant model of sepsis-related AKI.
DOI: 10.6084/m9.figshare.5835786.v1
title: Dataset for: P2X7 receptor antagonism ameliorates renal dysfunction in a rat model of sepsis

description: Sepsis is a major clinical problem associated with significant organ dysfunction and high mortality. The ATP-sensitive P2X7 receptor activates the NLRP3 inflammasome is a key component of the innate immune system. We used a fluid-resuscitated rat model of fecal peritonitis and acute kidney injury (AKI) to investigate the contribution of this purinergic receptor to renal dysfunction in sepsis. Six and 24 hour time-points were chosen to represent early and established sepsis, respectively. A selective P2X7 receptor antagonist (A-438079) dissolved in dimethyl sulfoxide (DMSO) was infused 2h following induction of sepsis. Compared with sham-operated animals, septic animals had significant increases in heart rate (-1(-4–8)% vs. 21(12-26)%; p=0.003)), fever (37.4(37.2-37.6)oC vs. 38.6(38.2-39.0)oC; p=0.0009), and falls in serum albumin (29(27-30)g/l vs. 26(24-28); p=0.0242). Serum IL-1 (0(0-10)(pg/ml) vs. 1671(1445-33778)(pg/ml); p&lt;0.001) and renal IL-1 (86(50-102)pg/mg protein vs. 200 (147-248)pg/mg protein; p=0.0031) were significantly elevated in septic compared with sham-operated animals at 6h. Serum creatinine was elevated in septic animals compared with sham-operated animals at 24h (23(22-25)mol/l vs. 28 (25-30)mol/l; p=0.0321). Renal IL-1 levels were significantly lower in A-438079-treated animals compared with untreated animals at 6h (70(5-128)pg/mg protein vs. 200(147-248)pg/mg protein; p=0.021). At 24h, compared with untreated animals, A-438079-treated animals had more rapid resolution of tachycardia (22(13-36)% vs. -1(-6-7)%; p=0.019) and fever (39.0(38.6-39.1)oC vs. 38.2(37.6-38.7)oC; p&lt;0.024), higher serum albumin (23(21-25)g/l vs. (27(25-28)g/l); p=0.006), lower arterial lactate (3.2(2.5-4.3)mmol/l vs.1.4(0.9-1.8)mmol/l; p=0.037), and lower serum creatinine concentrations (28(25-30)mol/l vs.22(17-27)mol/l; p=0.019). P2X7A treatment ameliorates the systemic inflammatory response and renal dysfunction in this clinically relevant model of sepsis-related AKI.
DOI: 10.6084/m9.figshare.5835783
title: Dataset for: LONG-TERM PROGRAMMING EFFECTS ON BLOOD PRESSURE FOLLOWING GESTATIONAL EXPOSURE TO THE IKR BLOCKER DOFETILIDE

description: A slow embryonic heart rate in early-mid gestation is associated with increased risk of embryonic death and malformation, however the long-term consequences are unknown. We administered Dofetilide (Dof, 2.5 mg/kg), a drug that produces embryo-specific bradycardia, to pregnant rats from gestational days 11-14. Embryonic heart rate and rhythm were determined using embryo culture. Cardiovascular function was assessed in surviving adult offspring at rest, during acute psychological stress (air jet stress, AJS), and after 7 days of repeated AJS. Dof reduced embryonic HR by 40% for ~8h on each of the treatment days. On postnatal day 3, Dof offspring were ~10% smaller. Blood pressure was elevated in adult Dof rats (systolic blood pressure, night: 103.8±3.9 vs 111.2±3.0 mmHg, P=0.01). While the pressor response to AJS was similar in both groups (control 17.7±3.4; Dof 18.9±0.9 mmHg, P=0.74), after 7 days repeated AJS, clear habituation was present in control (P=0.0001) but not Dof offspring (P=0.48). Only Dof offspring showed a small increase in resting blood pressure after 7 days repeated stress (+3.9±1.7 mmHg, P=0.05). The results indicate that embryonic bradycardia programs hypertension and impaired stress adaptation, and have implications for the maternal use of cardioactive drugs during pregnancy.
DOI: 10.6084/m9.figshare.5835783.v1
title: Dataset for: LONG-TERM PROGRAMMING EFFECTS ON BLOOD PRESSURE FOLLOWING GESTATIONAL EXPOSURE TO THE IKR BLOCKER DOFETILIDE

description: A slow embryonic heart rate in early-mid gestation is associated with increased risk of embryonic death and malformation, however the long-term consequences are unknown. We administered Dofetilide (Dof, 2.5 mg/kg), a drug that produces embryo-specific bradycardia, to pregnant rats from gestational days 11-14. Embryonic heart rate and rhythm were determined using embryo culture. Cardiovascular function was assessed in surviving adult offspring at rest, during acute psychological stress (air jet stress, AJS), and after 7 days of repeated AJS. Dof reduced embryonic HR by 40% for ~8h on each of the treatment days. On postnatal day 3, Dof offspring were ~10% smaller. Blood pressure was elevated in adult Dof rats (systolic blood pressure, night: 103.8±3.9 vs 111.2±3.0 mmHg, P=0.01). While the pressor response to AJS was similar in both groups (control 17.7±3.4; Dof 18.9±0.9 mmHg, P=0.74), after 7 days repeated AJS, clear habituation was present in control (P=0.0001) but not Dof offspring (P=0.48). Only Dof offspring showed a small increase in resting blood pressure after 7 days repeated stress (+3.9±1.7 mmHg, P=0.05). The results indicate that embryonic bradycardia programs hypertension and impaired stress adaptation, and have implications for the maternal use of cardioactive drugs during pregnancy.
DOI: 10.6084/m9.figshare.5835735
title: Associations between primary tumor <i>RAS</i>, <i>BRAF</i> and <i>PIK3CA</i> mutation status and metastatic site in patients with chemo-resistant metastatic colorectal cancer

description: <b>Background:</b> Several studies have investigated correlations between metastatic pattern and mutation status in patients with colorectal cancer (CRC). However, most of the studies were small and heterogeneously designed and further research is needed to confirm previous results. In this study, we investigated the association between <i>RAS</i> (<i>KRAS</i> or <i>NRAS</i>)<i>, BRAF</i>, <i>PIK3CA</i> mutations and metastatic pattern in patients with metastatic (m) CRC. <b>Material and methods:</b> This study reviewed Danish biobank and database of patients with mCRC who received cetuximab and irinotecan, independent of <i>RAS</i> mutation status, after fluoropyrimidine, oxaliplatin and irinotecan treatment failure. The database contained information regarding tumor mutation status of <i>KRAS</i>, <i>NRAS</i>, <i>BRAF</i> and <i>PIK3CA</i> genes. <b>Results:</b> Totally, 448 patients were included. On multivariate analyses, <i>RAS</i> mutations were significantly associated with increased odds of having lung metastases at diagnosis of mCRC (odds ratio (OR) = 2.04; 95% confidence interval (CI) = 1.32–3.17), and <i>PIK3CA</i> mutations with decreased odds of peritoneal metastases at diagnosis of mCRC (OR = 0.10; 95%CI = 0.01–0.79). On multivariate analyses of the hazard of developing metastases at any time during follow-up, <i>RAS</i> mutations were significantly associated with increased hazard of lung (hazard ratio (HR) = 1.34; 95%CI = 1.04–1.72) and ovarian metastases (HR = 3.12; 95%CI = 1.05–9.24), <i>BRAF</i> V600E mutation was associated with increased hazard of skin metastases (HR = 6.82; 95%CI = 1.86–25.02) and <i>PIK3CA</i> mutations with decreased hazard of peritoneal metastases (HR = 0.31; 95%CI = 0.11–0.86). <b>Conclusions:</b> This study indicated that in patients with mCRC, <i>RAS</i> mutations are associated with increased risk of lung and ovary metastases. <i>BRAF</i> V600E is associated with increased risk of skin metastases, and <i>PIK3CA</i> mutation with decreased risk of peritoneal metastases.
DOI: 10.6084/m9.figshare.5835735.v1
title: Associations between primary tumor <i>RAS</i>, <i>BRAF</i> and <i>PIK3CA</i> mutation status and metastatic site in patients with chemo-resistant metastatic colorectal cancer

description: <b>Background:</b> Several studies have investigated correlations between metastatic pattern and mutation status in patients with colorectal cancer (CRC). However, most of the studies were small and heterogeneously designed and further research is needed to confirm previous results. In this study, we investigated the association between <i>RAS</i> (<i>KRAS</i> or <i>NRAS</i>)<i>, BRAF</i>, <i>PIK3CA</i> mutations and metastatic pattern in patients with metastatic (m) CRC. <b>Material and methods:</b> This study reviewed Danish biobank and database of patients with mCRC who received cetuximab and irinotecan, independent of <i>RAS</i> mutation status, after fluoropyrimidine, oxaliplatin and irinotecan treatment failure. The database contained information regarding tumor mutation status of <i>KRAS</i>, <i>NRAS</i>, <i>BRAF</i> and <i>PIK3CA</i> genes. <b>Results:</b> Totally, 448 patients were included. On multivariate analyses, <i>RAS</i> mutations were significantly associated with increased odds of having lung metastases at diagnosis of mCRC (odds ratio (OR) = 2.04; 95% confidence interval (CI) = 1.32–3.17), and <i>PIK3CA</i> mutations with decreased odds of peritoneal metastases at diagnosis of mCRC (OR = 0.10; 95%CI = 0.01–0.79). On multivariate analyses of the hazard of developing metastases at any time during follow-up, <i>RAS</i> mutations were significantly associated with increased hazard of lung (hazard ratio (HR) = 1.34; 95%CI = 1.04–1.72) and ovarian metastases (HR = 3.12; 95%CI = 1.05–9.24), <i>BRAF</i> V600E mutation was associated with increased hazard of skin metastases (HR = 6.82; 95%CI = 1.86–25.02) and <i>PIK3CA</i> mutations with decreased hazard of peritoneal metastases (HR = 0.31; 95%CI = 0.11–0.86). <b>Conclusions:</b> This study indicated that in patients with mCRC, <i>RAS</i> mutations are associated with increased risk of lung and ovary metastases. <i>BRAF</i> V600E is associated with increased risk of skin metastases, and <i>PIK3CA</i> mutation with decreased risk of peritoneal metastases.
DOI: 10.6084/m9.figshare.5835726
title: Patterns of vertical cyst distribution and survival in 100-year-old sediment archives of three spring dinoflagellate species from the Northern Baltic Sea

description: The history of expansion of bloom-forming cold water dinoflagellates in the Northern Baltic Sea was studied using 100-year-old sediment archives of their resting cysts. Vertical cyst distributions of <i>Biecheleria baltica</i> and <i>Apocalathium malmogiense</i>, two dinoflagellates indistinguishable by light microscopy and not recognized as distinct species in monitoring, and chain-forming <i>Peridiniella catenata</i> were analysed in Pb<sup>210</sup> and Cs<sup>137</sup> dated layers of a sediment core from deep, hypoxic accumulation bottoms of the Gulf of Finland. Cyst profiles showed that <i>B. baltica</i> and <i>A. malmogiense</i> were already present in the Baltic spring phytoplankton community at the beginning of the 20th century. This confirms that <i>B. baltica</i>, which was only recognized in the late 1980s, is a native species in the area. A drastic increase in <i>B. baltica</i> cyst concentrations in the 1930s to 1960s coincided with the acceleration of anthropogenic eutrophication. Large cyst deposits accumulated over several decades in the sediment which, by the 1980s, amounted to the seed stock necessary to inoculate dominant blooms. In the cyst records <i>A. malmogiense</i> always contributed a minor fraction of the two species. <i>P. catenata</i> had a relatively short cyst record in Gulf of Finland sediments despite demonstrated long-term presence in the plankton, which emphasizes that cyst-based historic surveys are not suitable for all cyst-forming dinoflagellates. This was corroborated by correspondence analyses of long-term plankton and cyst records which validated the trends from the sediment archive for <i>B. baltica</i> and <i>A. malmogiense</i>, but failed to do so for <i>P. catenata</i>. Germination experiments with 100-year-old cysts revealed a remarkable long-term survival capacity of <i>A. malmogiense</i>, making this species a suitable model for resurrection studies testing adaptation in heavily impacted systems such as the Baltic Sea.
DOI: 10.6084/m9.figshare.5835726.v1
title: Patterns of vertical cyst distribution and survival in 100-year-old sediment archives of three spring dinoflagellate species from the Northern Baltic Sea

description: The history of expansion of bloom-forming cold water dinoflagellates in the Northern Baltic Sea was studied using 100-year-old sediment archives of their resting cysts. Vertical cyst distributions of <i>Biecheleria baltica</i> and <i>Apocalathium malmogiense</i>, two dinoflagellates indistinguishable by light microscopy and not recognized as distinct species in monitoring, and chain-forming <i>Peridiniella catenata</i> were analysed in Pb<sup>210</sup> and Cs<sup>137</sup> dated layers of a sediment core from deep, hypoxic accumulation bottoms of the Gulf of Finland. Cyst profiles showed that <i>B. baltica</i> and <i>A. malmogiense</i> were already present in the Baltic spring phytoplankton community at the beginning of the 20th century. This confirms that <i>B. baltica</i>, which was only recognized in the late 1980s, is a native species in the area. A drastic increase in <i>B. baltica</i> cyst concentrations in the 1930s to 1960s coincided with the acceleration of anthropogenic eutrophication. Large cyst deposits accumulated over several decades in the sediment which, by the 1980s, amounted to the seed stock necessary to inoculate dominant blooms. In the cyst records <i>A. malmogiense</i> always contributed a minor fraction of the two species. <i>P. catenata</i> had a relatively short cyst record in Gulf of Finland sediments despite demonstrated long-term presence in the plankton, which emphasizes that cyst-based historic surveys are not suitable for all cyst-forming dinoflagellates. This was corroborated by correspondence analyses of long-term plankton and cyst records which validated the trends from the sediment archive for <i>B. baltica</i> and <i>A. malmogiense</i>, but failed to do so for <i>P. catenata</i>. Germination experiments with 100-year-old cysts revealed a remarkable long-term survival capacity of <i>A. malmogiense</i>, making this species a suitable model for resurrection studies testing adaptation in heavily impacted systems such as the Baltic Sea.
DOI: 10.6084/m9.figshare.5835627
title: Data - How postcopulatory investment by unarmed males can explain male morph coexistence in a male dimorphic mite

description: Dataset used for the analysis for 'How postcopulatory investment by unarmed males can explain male morph coexistence in a male dimorphic mite' by Tom P.G. van den Beuken and Isabel M. Smallegange.<br>
DOI: 10.6084/m9.figshare.5835627.v2
title: Data - How postcopulatory investment by unarmed males can explain male morph coexistence in a male dimorphic mite

description: Dataset used for the analysis for 'How postcopulatory investment by unarmed males can explain male morph coexistence in a male dimorphic mite' by Tom P.G. van den Beuken and Isabel M. Smallegange.<br>
DOI: 10.6084/m9.figshare.5835627.v1
title: Data - How postcopulatory investment by unarmed males can explain male morph coexistence in a male dimorphic mite

description: Dataset used for the analysis for 'How postcopulatory investment by unarmed males can explain male morph coexistence in a male dimorphic mite' by Tom P.G. van den Beuken and Isabel M. Smallegange.<br>
DOI: 10.6084/m9.figshare.5835609
title: First-year undergraduate business students’ utilisation of learning support for assumed mathematics skills

description: These de-identified data describe a cohort of Flinders University first year economics students and their experiences with and attitudes towards mathematics in the context of their studies.<br>Variables include basic demographic data, perceived comfortableness with maths, and both formal and informal experience with maths skills training.<br>Data are saved in SPSS format, and are openable in IBM SPSS Statistics 25.<br>These data were collected under approval of the Flinders University Social and Behavioural Research Ethics Committee, project number 6015. Analysed data are presented in a concurrent manuscript.
DOI: 10.6084/m9.figshare.5835609.v1
title: First-year undergraduate business students’ utilisation of learning support for assumed mathematics skills

description: These de-identified data describe a cohort of Flinders University first year economics students and their experiences with and attitudes towards mathematics in the context of their studies.<br>Variables include basic demographic data, perceived comfortableness with maths, and both formal and informal experience with maths skills training.<br>Data are saved in SPSS format, and are openable in IBM SPSS Statistics 25.<br>These data were collected under approval of the Flinders University Social and Behavioural Research Ethics Committee, project number 6015. Analysed data are presented in a concurrent manuscript.