cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.29071937.v1
title: Chronic hepatitis B infection and pre-eclampsia/eclampsia: a Mendelian randomisation study

description: This study aimed to investigate the potential causal association between chronic hepatitis B (CHB) infection and the risk of pre-eclampsia/eclampsia using a Mendelian randomisation (MR) design. We conducted a two-sample MR analysis using genome-wide association study (GWAS) summary statistics from three large-scale datasets. For CHB infection, we used data from 351,885 individuals UK Biobank. For pre‑eclampsia/eclampsia, we analysed two FinnGen datasets with sample sizes of 118,291 and 126,760 individuals, respectively. Genetic variants strongly associated with CHB infection (<i>p</i> &lt; 5 × 10<sup>−8</sup>) were selected as instrumental variables. The inverse-variance weighted (IVW) method was employed as the primary analysis. Sensitivity analyses included MR-Egger regression, weighted median, weighted mode and MR-PRESSO. Cochran’s <i>Q</i> test and MR-Egger intercept tests were performed to assess heterogeneity and horizontal pleiotropy, respectively. MR analysis revealed significant positive genetic associations between CHB infection and increased risk of pre-eclampsia (OR = 1.154, 95%CI = 1.014–1.313, <i>p</i> = .029) and eclampsia (OR = 1.561, 95%CI = 1.030–2.366, <i>p</i> = .035). Findings were robust across sensitivity analyses for both outcomes. Our study provides genetic evidence that CHB infection increases the risk of both pre-eclampsia and eclampsia. These findings suggest that considering CHB status as a risk factor and implementing targeted HBV screening programmes may be beneficial for pregnant women. This study explored the link between long-term hepatitis B infection (chronic hepatitis B, CHB) and two serious pregnancy complications: pre-eclampsia and eclampsia. Chronic hepatitis B is a persistent liver infection. Pre-eclampsia and eclampsia cause high blood pressure in pregnant women; eclampsia also involves seizures, posing risks to both mother and baby. We used genetic information to investigate whether having a higher genetic chance of getting CHB also increases the risk of developing these pregnancy problems. Our results consistently show that women with a genetic predisposition to CHB infection appear to have a higher risk of developing both pre-eclampsia and eclampsia. This suggests that being aware of a woman’s hepatitis B status during pregnancy could be important. Close monitoring for early signs of pre-eclampsia or eclampsia might be beneficial for pregnant women with CHB to help ensure their safety and the health of their baby.
DOI: 10.48597/fnkt-zcpr
title: Measurement of HCB at Pallas (Matorova)

description: Measurement of HCB at Pallas (Matorova)
DOI: 10.6084/m9.figshare.28152027
title: Predictors of treatment failure of tubal pregnancy with single-dose methotrexate regimen – a systematic review and meta-analysis

description: Ectopic pregnancies represent a potentially life-threatening medical emergency, with 95% being tubal. This meta-analysis aimed to identify early predictors for single-dose methotrexate (MTX) treatment failure in tubal pregnancies. A literature search was conducted across several databases from their inception to December 2023, with references in the selected studies manually reviewed. 14 studies involving 2,804 patients were included in this meta-analysis. The results revealed that higher serum beta-human chorionic gonadotropin (β-hCG) levels on Day 1 (SMD = 1.25, 95% CI 0.73–1.77), foetal cardiac activity presence (OR = 12.64, 95% CI 3.15–50.75), adnexal mass presence (OR = 4.66, 95% CI 2.02–10.74), yolk sac presence (OR = 5.35, 95% CI 2.33–12.27), thicker endometrium (MD = 1.74, 95% CI 0.30–3.19), more number of previous ectopic pregnancies (MD = 0.21, 95% CI 0.13–0.30), history of pelvic inflammatory disease (PID) (OR = 3.97, 95% CI 2.02–7.79), higher progesterone levels on Day 1 (SMD = 0.22, 95% CI 0.07–0.36), a higher 48-hour pre-treatment increment in serum β-hCG percentage (MD = 11.46, 95% CI 2.95–19.98), and a higher percentage of serum β-hCG change from Day 4 to Day 0/1 (SMD = 2.58, 95% CI 1.02–4.14) were early predictive factors for treatment failure of tubal pregnancy with the MTX single-dose regimen. This review clarifies early predictive factors for treatment failure with the MTX single-dose regimen in tubal pregnancies. High-risk tubal pregnancies likely to fail MTX monotherapy could be identified earlier, allowing for personalised intervention measures to be implemented at an early stage to prevent harm and improve treatment outcomes. Higher serum β-hCG levels on Day 1, foetal cardiac activity presence, adnexal mass presence, yolk sac presence, thicker endometrium, more number of previous ectopic pregnancies, history of PID, higher progesterone levels on Day 1, a higher 48-hour pre-treatment increment in serum β-hCG percentage, and a higher percentage of serum β-hCG change from Day 4 to Day 0/1 increase the risk of treatment failure of tubal pregnancy with methotrexate single-dose regimen.
DOI: 10.6084/m9.figshare.28152027.v1
title: Predictors of treatment failure of tubal pregnancy with single-dose methotrexate regimen – a systematic review and meta-analysis

description: Ectopic pregnancies represent a potentially life-threatening medical emergency, with 95% being tubal. This meta-analysis aimed to identify early predictors for single-dose methotrexate (MTX) treatment failure in tubal pregnancies. A literature search was conducted across several databases from their inception to December 2023, with references in the selected studies manually reviewed. 14 studies involving 2,804 patients were included in this meta-analysis. The results revealed that higher serum beta-human chorionic gonadotropin (β-hCG) levels on Day 1 (SMD = 1.25, 95% CI 0.73–1.77), foetal cardiac activity presence (OR = 12.64, 95% CI 3.15–50.75), adnexal mass presence (OR = 4.66, 95% CI 2.02–10.74), yolk sac presence (OR = 5.35, 95% CI 2.33–12.27), thicker endometrium (MD = 1.74, 95% CI 0.30–3.19), more number of previous ectopic pregnancies (MD = 0.21, 95% CI 0.13–0.30), history of pelvic inflammatory disease (PID) (OR = 3.97, 95% CI 2.02–7.79), higher progesterone levels on Day 1 (SMD = 0.22, 95% CI 0.07–0.36), a higher 48-hour pre-treatment increment in serum β-hCG percentage (MD = 11.46, 95% CI 2.95–19.98), and a higher percentage of serum β-hCG change from Day 4 to Day 0/1 (SMD = 2.58, 95% CI 1.02–4.14) were early predictive factors for treatment failure of tubal pregnancy with the MTX single-dose regimen. This review clarifies early predictive factors for treatment failure with the MTX single-dose regimen in tubal pregnancies. High-risk tubal pregnancies likely to fail MTX monotherapy could be identified earlier, allowing for personalised intervention measures to be implemented at an early stage to prevent harm and improve treatment outcomes. Higher serum β-hCG levels on Day 1, foetal cardiac activity presence, adnexal mass presence, yolk sac presence, thicker endometrium, more number of previous ectopic pregnancies, history of PID, higher progesterone levels on Day 1, a higher 48-hour pre-treatment increment in serum β-hCG percentage, and a higher percentage of serum β-hCG change from Day 4 to Day 0/1 increase the risk of treatment failure of tubal pregnancy with methotrexate single-dose regimen.
DOI: 10.15468/dl.mbhdna
title: Occurrence Download

description: A dataset containing 47187485 species occurrences available in GBIF matching the query:
{
 "and" : [
 "BasisOfRecord is one of (Observation, Human Observation, Material sample, Material citation, Specimen, Occurrence evidence)",
 "CoordinateUncertaintyInMeters 1000.0-1000000.0",
 "OccurrenceStatus is Present",
 "TaxonKey is Aves",
 "Year 1980-2010"
 ]
}

 The dataset includes 47187485 records from 1124 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0049584-251120083545085/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.48597/ryq6-8zwk
title: Measurement of HCB at Pallas (Matorova)

description: Measurement of HCB at Pallas (Matorova)
DOI: 10.48597/v639-3b94
title: Measurement of HCB at Pallas (Matorova)

description: Measurement of HCB at Pallas (Matorova)
DOI: 10.6084/m9.figshare.30092151
title: Women’s knowledge, attitudes and interest in antenatal perineal massage – a cross-sectional survey

description: Antenatal perineal massage (APM) is an established technique for preventing severe perineal trauma, but it is uncommonly practised in Hong Kong. This study aimed to investigate pregnant women’s knowledge, attitudes and interest in APM, and to identify factors that influence their interest in the technique. A prospective cross-sectional study was conducted over 7 months at Princess Margaret Hospital. Pregnant women aged 18 years or above and under 37 weeks of gestation were invited to participate via a bilingual questionnaire distributed during antenatal clinic visits. Descriptive and regression analyses were used. Out of 385 respondents, only 31.4% were aware of APM with social media (61.2%) as their main source of knowledge. Only 44.8% of the questions were answered correctly, with a median knowledge score of 3.0 out of 7. A majority were unaware of the long-term impacts of severe perineal injury (57.7%) and potential benefits of perineal massage (54.5%), highlighting a deficiency of knowledge. Interest in APM was high (66.2%). Non-Chinese, higher education, planned vaginal delivery and knowledge of the technique’s benefit are positive predictors of expressed interest. However, concerns about discomfort (38.5%) and embarrassment (38.5%) were notable barriers to participation. Among those who practised APM, the median Likert score was 4 out of 5, indicating a generally positive perception of its benefits. This study reveals important areas where knowledge regarding obstetric anal sphincter injuries (OASIS) and APM is lacking among some pregnant women in Hong Kong. There is a need to enhance education and resources regarding these topics in antenatal classes. Some women experience tearing around the vaginal area during childbirth, which may lead to pain, bladder or bowel issues, or discomfort during sex. One method that may help prevent these tears is a gentle massage of the area between the vagina and anus (called perineum) in the last few weeks of pregnancy. This study looked at how much pregnant women in Hong Kong know about this type of massage, how they feel about it, and whether they would be willing to learn it. We invited 385 women at a public hospital to complete a questionnaire during their pregnancy, and a follow-up section after they gave birth. We found that only about one-third had heard of perineal massage, and many did not know about the possible long-term effects of severe tearing during birth. However, two out of three women said they were interested in learning about the massage. Women were more likely to be interested if they had higher education, were not-Chinese, planned vaginal birth, or know about the massage’s benefits. At the same time, many of these women had concerns that made them unsure – such as discomfort, embarrassment or not knowing how to do the massage properly. These concerns may hold women back even when they are interested. This study shows that more education about perineal massage is needed during pregnancy to help women make informed choices.
DOI: 10.6084/m9.figshare.30092151.v1
title: Women’s knowledge, attitudes and interest in antenatal perineal massage – a cross-sectional survey

description: Antenatal perineal massage (APM) is an established technique for preventing severe perineal trauma, but it is uncommonly practised in Hong Kong. This study aimed to investigate pregnant women’s knowledge, attitudes and interest in APM, and to identify factors that influence their interest in the technique. A prospective cross-sectional study was conducted over 7 months at Princess Margaret Hospital. Pregnant women aged 18 years or above and under 37 weeks of gestation were invited to participate via a bilingual questionnaire distributed during antenatal clinic visits. Descriptive and regression analyses were used. Out of 385 respondents, only 31.4% were aware of APM with social media (61.2%) as their main source of knowledge. Only 44.8% of the questions were answered correctly, with a median knowledge score of 3.0 out of 7. A majority were unaware of the long-term impacts of severe perineal injury (57.7%) and potential benefits of perineal massage (54.5%), highlighting a deficiency of knowledge. Interest in APM was high (66.2%). Non-Chinese, higher education, planned vaginal delivery and knowledge of the technique’s benefit are positive predictors of expressed interest. However, concerns about discomfort (38.5%) and embarrassment (38.5%) were notable barriers to participation. Among those who practised APM, the median Likert score was 4 out of 5, indicating a generally positive perception of its benefits. This study reveals important areas where knowledge regarding obstetric anal sphincter injuries (OASIS) and APM is lacking among some pregnant women in Hong Kong. There is a need to enhance education and resources regarding these topics in antenatal classes. Some women experience tearing around the vaginal area during childbirth, which may lead to pain, bladder or bowel issues, or discomfort during sex. One method that may help prevent these tears is a gentle massage of the area between the vagina and anus (called perineum) in the last few weeks of pregnancy. This study looked at how much pregnant women in Hong Kong know about this type of massage, how they feel about it, and whether they would be willing to learn it. We invited 385 women at a public hospital to complete a questionnaire during their pregnancy, and a follow-up section after they gave birth. We found that only about one-third had heard of perineal massage, and many did not know about the possible long-term effects of severe tearing during birth. However, two out of three women said they were interested in learning about the massage. Women were more likely to be interested if they had higher education, were not-Chinese, planned vaginal birth, or know about the massage’s benefits. At the same time, many of these women had concerns that made them unsure – such as discomfort, embarrassment or not knowing how to do the massage properly. These concerns may hold women back even when they are interested. This study shows that more education about perineal massage is needed during pregnancy to help women make informed choices.
DOI: 10.6084/m9.figshare.30354607
title: Obstetric violence prevalence and risk factors: an umbrella review

description: Obstetric violence (OV) is a gender-based human rights violation during pregnancy, labour, and postpartum. Despite increasing recognition, the global prevalence and risk factors associated with OV remain poorly understood. We aim to estimate the prevalence of OV worldwide, examine regional disparities, and identify the associated risk factors through an umbrella review. After prospective registration (PROSPERO CRD42025631985), a comprehensive search was conducted in PubMed, Scopus, Web of Science, and Scielo for reviews published between January 2015 and March 2025. Two reviewers independently selected studies, extracted data, and assessed methodological quality using the AMSTAR 2 tool. Overlap of studies among the included reviews was quantified using the corrected covered area (CCA). The risk factor data were summarised as odds ratio (OR) with 95% confidence interval (CI). Fourteen reviews, with a total of 1,116,159 participants, were included; of which 10 (71.4%) were of critically low or low quality and only one review was high quality. The CCA was very low at 1.136%. OV prevalence varied from 23.2% to 59%, depending on region and definitional criteria. Forms of OV included physical (3.1–78.4%), verbal or psychological (2.6–66%), and social (1.9–94%) mistreatment. Statistically significant risk factors included low socioeconomic status (maximum OR = 3.68; 95% CI = 1.4–9.7), obstetric complications (maximum OR = 6.41; 95% CI: 1.36–30.14), limited education (OR = 5.92; 95% CI 1.38–23.81), public healthcare births (maximum OR = 4.34; IC 95%: 1.58–11.97), instrumental delivery (OR = 2.35; 95% CI: 1.72–3.22), and inadequate provider training (OR = 1.47; 95% CI: 1.05–2.04). OV is a prevalent global issue. Vulnerable populations, i.e. those with lower socioeconomic status and limited education, were more often affected. The low methodological quality of the existing literature is a key weakness. There is a need for standardised definitions and improved research validity for the development of evidence-based interventions. This umbrella review analyses the prevalence and risk factors associated with obstetric violence, a widespread issue affecting pregnant women in healthcare settings. By summarising evidence from multiple studies, the review aims to highlight the scope of the problem and identify key factors contributing to this harmful practice. Understanding these elements can help healthcare providers and policymakers improve maternal care and protect women’s rights during childbirth.
DOI: 10.6084/m9.figshare.30354607.v1
title: Obstetric violence prevalence and risk factors: an umbrella review

description: Obstetric violence (OV) is a gender-based human rights violation during pregnancy, labour, and postpartum. Despite increasing recognition, the global prevalence and risk factors associated with OV remain poorly understood. We aim to estimate the prevalence of OV worldwide, examine regional disparities, and identify the associated risk factors through an umbrella review. After prospective registration (PROSPERO CRD42025631985), a comprehensive search was conducted in PubMed, Scopus, Web of Science, and Scielo for reviews published between January 2015 and March 2025. Two reviewers independently selected studies, extracted data, and assessed methodological quality using the AMSTAR 2 tool. Overlap of studies among the included reviews was quantified using the corrected covered area (CCA). The risk factor data were summarised as odds ratio (OR) with 95% confidence interval (CI). Fourteen reviews, with a total of 1,116,159 participants, were included; of which 10 (71.4%) were of critically low or low quality and only one review was high quality. The CCA was very low at 1.136%. OV prevalence varied from 23.2% to 59%, depending on region and definitional criteria. Forms of OV included physical (3.1–78.4%), verbal or psychological (2.6–66%), and social (1.9–94%) mistreatment. Statistically significant risk factors included low socioeconomic status (maximum OR = 3.68; 95% CI = 1.4–9.7), obstetric complications (maximum OR = 6.41; 95% CI: 1.36–30.14), limited education (OR = 5.92; 95% CI 1.38–23.81), public healthcare births (maximum OR = 4.34; IC 95%: 1.58–11.97), instrumental delivery (OR = 2.35; 95% CI: 1.72–3.22), and inadequate provider training (OR = 1.47; 95% CI: 1.05–2.04). OV is a prevalent global issue. Vulnerable populations, i.e. those with lower socioeconomic status and limited education, were more often affected. The low methodological quality of the existing literature is a key weakness. There is a need for standardised definitions and improved research validity for the development of evidence-based interventions. This umbrella review analyses the prevalence and risk factors associated with obstetric violence, a widespread issue affecting pregnant women in healthcare settings. By summarising evidence from multiple studies, the review aims to highlight the scope of the problem and identify key factors contributing to this harmful practice. Understanding these elements can help healthcare providers and policymakers improve maternal care and protect women’s rights during childbirth.
DOI: 10.48597/6hpq-vc79
title: Measurement of HCB at Pallas (Matorova)

description: Measurement of HCB at Pallas (Matorova)
DOI: 10.6084/m9.figshare.29633768
title: Abnormal expression of Hippo–YAP1 signalling pathway and progesterone resistance mechanism in endometrial polyps

description: Endometrial polyps (EPs) are a localised hyperproliferative disorder of the endometrium, and its pathogenesis remains unclear. Progesterone resistance may influence the recurrence rate of progesterone-treated EPs. Expression of the Hippo–YAP1 signalling pathway has been studied in various diseases. However, few studies have explored their expression in EPs and association with progesterone resistance. Prolactin (PRL), a molecular marker of endometrial mesenchymal cell metaplasia, indirectly reflects progesterone action <i>in vivo</i>. This study aimed to explore the role of Hippo–YAP1 signalling pathway in EPs. Endometrial tissue specimens obtained by surgical resection from 35 patients with a normal endometrium and 35 with EPs were collected between July 2023 and July 2024. Immunohistochemically, the expressions of mammalian STE20-like kinase 1 (MST1), Yes-associated protein 1 (YAP1), progesterone receptor (PR) and PRL in the normal endometrium and EPs tissues were detected. Compared to normal endometrial tissues, the expression of MST1 was relatively low in EPs (<i>p</i> &lt; .05), while the total and nuclear expression of YAP1 was relatively high in EPs (<i>p</i> &lt; .0001). The expression of PR in EPs tissues was significantly lower than that in normal endometrial tissues (<i>p</i> &lt; .05), and the expression level of PRL was lower than that of normal endometrium in EPs tissues (<i>p</i> &lt; .001). EPs have progesterone resistance, and the Hippo–YAP1 signalling pathway may be involved in the development and progression of EPs by acting on the progesterone resistance mechanism. Endometrial polyps (EPs) is a common benign gynaecological disease, formed by the overgrowth of local endometrial tissue. Its main clinical manifestations are abnormal uterine bleeding or infertility, which seriously affects the physical and mental health of patients. In addition, during progesterone therapy, some patients have poor efficacy, which may be related to progesterone resistance, and it becomes an important challenge for clinical treatment. The aim of this study was to investigate the possible pathogenesis of EPs and their progesterone resistance mechanism. Our study found that the Hippo signalling pathway, which regulates cell growth, may be involved in the process of polyp formation and mediate the development of progesterone resistance. This finding may provide a new perspective for understanding the pathogenesis of EPs and may provide a theoretical basis for the development of new therapeutic targets.