cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.5281/zenodo.4972098
title: miR-145-5p mimic inhibits bone metastasis of prostate cancer via the regulation of epithelial mesenchymal transition

description: <strong>Background.</strong> The bone is the most common site of distant metastasis in prostate cancer. However, treatments for the bone metastasis of prostate cancer remain unsatisfactory. MicroRNAs (miRNAs) are small noncoding RNAs that play a variety of critical roles in tumor development and progression. Studies have confirmed that miRNA mimics could regulate the response to therapy in many cancers. <strong>Methods.</strong> In this study, a set of forty-four miRNAs were reduced in prostate cancer patients with bone metastases by high-throughput sequencing analysis. Wound healing and transwell assays and western blotting analysis were used to explore the role of miRNA mimic in prostate cancer bone metastasis.<strong> Results.</strong> These mimics of down-regulated miRNAs may be able to cure prostate cancer bone metastasis, including hsa-miR-221-3p, hsa-miR-222-3p, hsa-miR-133a-3p, hsa-miR-222-5p, hsa-miR-204-3p, hsa-miR-145-5p, hsa-miR-3681-5p, hsa-miR-184, hsa-miR-144-3p, hsa-miR-204-5p, and hsa-miR-221-5p. To further investigate the role of these miRNA mimics on prostate cancer bone metastasis, miR-145-5p was randomly selected for validation. Bioinformatics analysis showed that miR-145-5p target genes significantly affected TGF-beta signaling pathway. Wound healing and transwell assays and western blotting analysis revealed that miR-145-5p mimic inhibited proliferation, migration and invasion. Importantly, miR-145-5p mimic increased the expression of E-cadherin and reduced the expression of matrix metalloproteinase 2 and 9. These results revealed that miR-145-5p mimic mediated epithelial mesenchymal transition. Meanwhile, miR-145-5p mimic enhanced the level of caspase 9, which is an important promoter of apoptosis. These results indicate that miR-145-5p mimic could inhibit the progress of prostate cancer bone metastasis via regulation of epithelial mesenchymal transition. In addition, miR-145-5p mimic could induce the apoptosis of prostate cancer cells with bone metastases. In summary, the miR-145-5p mimic is expected to become a novel strategy for the treatment of tumor metastasis.
DOI: 10.5281/zenodo.4970561
title: miR-145-5p mimic inhibits bone metastasis of prostate cancer via the regulation of epithelial mesenchymal transition

description: <strong>Background.</strong> The bone is the most common site of distant metastasis in prostate cancer. However, treatments for the bone metastasis of prostate cancer remain unsatisfactory. MicroRNAs (miRNAs) are small noncoding RNAs that play a variety of critical roles in tumor development and progression. Studies have confirmed that miRNA mimics could regulate the response to therapy in many cancers. <strong>Methods.</strong> In this study, a set of forty-four miRNAs were reduced in prostate cancer patients with bone metastases by high-throughput sequencing analysis. Wound healing and transwell assays and western blotting analysis were used to explore the role of miRNA mimic in prostate cancer bone metastasis.<strong> Results.</strong> These mimics of down-regulated miRNAs may be able to cure prostate cancer bone metastasis, including hsa-miR-221-3p, hsa-miR-222-3p, hsa-miR-133a-3p, hsa-miR-222-5p, hsa-miR-204-3p, hsa-miR-145-5p, hsa-miR-3681-5p, hsa-miR-184, hsa-miR-144-3p, hsa-miR-204-5p, and hsa-miR-221-5p. To further investigate the role of these miRNA mimics on prostate cancer bone metastasis, miR-145-5p was randomly selected for validation. Bioinformatics analysis showed that miR-145-5p target genes significantly affected TGF-beta signaling pathway. Wound healing and transwell assays and western blotting analysis revealed that miR-145-5p mimic inhibited proliferation, migration and invasion. Importantly, miR-145-5p mimic increased the expression of E-cadherin and reduced the expression of matrix metalloproteinase 2 and 9. These results revealed that miR-145-5p mimic mediated epithelial mesenchymal transition. Meanwhile, miR-145-5p mimic enhanced the level of caspase 9, which is an important promoter of apoptosis. These results indicate that miR-145-5p mimic could inhibit the progress of prostate cancer bone metastasis via regulation of epithelial mesenchymal transition. In addition, miR-145-5p mimic could induce the apoptosis of prostate cancer cells with bone metastases. In summary, the miR-145-5p mimic is expected to become a novel strategy for the treatment of tumor metastasis.
DOI: 10.6084/m9.figshare.14805537
title: Wind analysis for windsport

description: These are supplementary files to a research paper in wind conditions over Europe and its surroundings.
DOI: 10.6084/m9.figshare.14805537.v1
title: Wind analysis for windsport

description: These are supplementary files to a research paper in wind conditions over Europe and its surroundings.
DOI: 10.5519/qd.j32l7kkw
title: Query on the Natural History Museum Data Portal (data.nhm.ac.uk) (421 records)
DOI: 10.5517/ccdc.csd.cc21jx2l
title: CCDC 1893079: Experimental Crystal Structure Determination

description: Related Article: Fabien Lucas, Nemo McIntosh, Emmanuel Jacques, Christophe Lebreton, Benoît Heinrich, Bertrand Donnio, Olivier Jeannin, Joëlle Rault-Berthelot, Cassandre Quinton, Jérôme Cornil, Cyril Poriel|2021|J.Am.Chem.Soc.|143|8804|doi:10.1021/jacs.1c03240
description: Related Article: Fabien Lucas, Lambert Sicard, Olivier Jeannin, Joëlle Rault‐Berthelot, Emmanuel Jacques, Cassandre Quinton, Cyril Poriel|2019|Chem.-Eur.J.|25|7740|doi:10.1002/chem.201901066
DOI: 10.5517/ccdc.csd.cc23hnhs
title: CCDC 1951465: Experimental Crystal Structure Determination

description: Related Article: Li Tian, Chen Wang, Hongwei Zhao, Fuwei Sun, Hao Dong, Kai Feng, Peng Wang, Guokang He, Guangtao Li|2021|J.Am.Chem.Soc.|143|8631|doi:10.1021/jacs.0c13377
DOI: 10.5517/ccdc.csd.cc24sc7k
title: CCDC 1989618: Experimental Crystal Structure Determination

description: Related Article: James O. Taylor, Ryan Culpeck, Ann M. Chippindale, Maria José Calhorda, František Hartl|2021|Organometallics|40|1598|doi:10.1021/acs.organomet.1c00038
DOI: 10.5517/ccdc.csd.cc24sccp
title: CCDC 1989622: Experimental Crystal Structure Determination

description: Related Article: James O. Taylor, Ryan Culpeck, Ann M. Chippindale, Maria José Calhorda, František Hartl|2021|Organometallics|40|1598|doi:10.1021/acs.organomet.1c00038
DOI: 10.5517/ccdc.csd.cc24scdq
title: CCDC 1989623: Experimental Crystal Structure Determination

description: Related Article: James O. Taylor, Ryan Culpeck, Ann M. Chippindale, Maria José Calhorda, František Hartl|2021|Organometallics|40|1598|doi:10.1021/acs.organomet.1c00038
DOI: 10.5517/ccdc.csd.cc251snp
title: CCDC 1997722: Experimental Crystal Structure Determination

description: Related Article: Jinxiu Xu, Yanji Song, Jun He, Shunxi Dong, Lili Lin, Xiaoming Feng|2021|Angew.Chem.,Int.Ed.|60|14521|doi:10.1002/anie.202102054
DOI: 10.5517/ccdc.csd.cc257c2w
title: CCDC 2003067: Experimental Crystal Structure Determination

description: Related Article: Aabid A. Wani, Sumit S. Chourasiya, Deepika Kathuria, Subash C. Sahoo, Uwe Beifuss, Prasad V. Bharatam|2021|J.Org.Chem.|86|7659|doi:10.1021/acs.joc.1c00704
DOI: 10.5517/ccdc.csd.cc25nyf7
title: CCDC 2016129: Experimental Crystal Structure Determination

description: Related Article: Jinxiu Xu, Yanji Song, Jun He, Shunxi Dong, Lili Lin, Xiaoming Feng|2021|Angew.Chem.,Int.Ed.|60|14521|doi:10.1002/anie.202102054
DOI: 10.5517/ccdc.csd.cc2662bv
title: CCDC 2031626: Experimental Crystal Structure Determination

description: Related Article: Jinxiu Xu, Yanji Song, Jun He, Shunxi Dong, Lili Lin, Xiaoming Feng|2021|Angew.Chem.,Int.Ed.|60|14521|doi:10.1002/anie.202102054
DOI: 10.5517/ccdc.csd.cc26zm72
title: CCDC 2055214: Experimental Crystal Structure Determination

description: Related Article: Fabien Lucas, Nemo McIntosh, Emmanuel Jacques, Christophe Lebreton, Benoît Heinrich, Bertrand Donnio, Olivier Jeannin, Joëlle Rault-Berthelot, Cassandre Quinton, Jérôme Cornil, Cyril Poriel|2021|J.Am.Chem.Soc.|143|8804|doi:10.1021/jacs.1c03240
DOI: 10.5517/ccdc.csd.cc26zm83
title: CCDC 2055215: Experimental Crystal Structure Determination

description: Related Article: Fabien Lucas, Nemo McIntosh, Emmanuel Jacques, Christophe Lebreton, Benoît Heinrich, Bertrand Donnio, Olivier Jeannin, Joëlle Rault-Berthelot, Cassandre Quinton, Jérôme Cornil, Cyril Poriel|2021|J.Am.Chem.Soc.|143|8804|doi:10.1021/jacs.1c03240
DOI: 10.5517/ccdc.csd.cc272rhl
title: CCDC 2058229: Experimental Crystal Structure Determination

description: Related Article: Yonghong Guo, Meng-Meng Liu, Xujiang Zhu, Liru Zhu, Chuan He|2021|Angew.Chem.,Int.Ed.|60|13887|doi:10.1002/anie.202103748
DOI: 10.6084/m9.figshare.14805690
title: Supplementary Material for: Meta-Analysis of the Relationship between Abdominal Obesity and Diabetic Kidney Disease in Type 2 Diabetic Patients

description: <b><i>Background and Objectives:</i></b> The meta-analysis aimed to investigate the association of visceral fat area (VFA), waist circumference (WC), waist-hip ratio (WHR) and waist-height ratio (WHtR) with diabetic kidney disease (DKD) in type 2 diabetic patients. <b><i>Methods:</i></b> Included studies were searched from Pubmed, Embase, and the Cochrane Library before July 2020. We synthesized the pooled results of the above relationships by meta-analysis. <b><i>Results:</i></b> Fourteen cross-sectional studies were enrolled. The pooled results indicated there was a significant difference in continuous VFA, WC and WHR/WHtR between patients with DKD and those without DKD (standard mean difference, SMD, 0.24, 95% confidence interval, CI, 0.13–0.36, <i>p</i> = 0.000). For VFA, patients with DKD had higher VFA levels than those without DKD (SMD 0.27, 95% CI 0.03–0.50). In the WC subgroup, patients with DKD had higher WC levels than those without DKD (SMD 0.17, 95% CI 0.10–0.24); similarly, abdominal obesity (dichotomized WC) was significantly associated with an increase in the odds of DKD (expected shortfall, ES, 1.57, 95% CI 1.32–1.86). However, the association of continuous WHR/WHtR with DKD was not statistically significant (SMD 0.43, 95% CI –0.12 to 0.97), while we found this relationship was statistically significant when analyzed categorically (ES 1.58, 95% CI 1.22–2.06). <b><i>Conclusion:</i></b> In this meta-analysis, we found abdominal obesity parameters (continuous VFA, WC) were associated with increased odds of DKD, and type 2 diabetic patients with DKD were more likely to have abdominal obesity (categorized using WC or WHR/WHtR).
DOI: 10.5281/zenodo.4030699
title: CASSMIR

description: <strong>Please refer to the latest version of the project</strong> For free and complete informations concerning CASSMIR datasets, please visit our website (in French).
DOI: 10.5281/zenodo.4980170
title: Gado2: multilingual newspapers from the Netherlands Indies

description: This Handwritten Text Recognition (HTR) xml-page file dataset contains the ground truths of the Gado2 named entity processing application for newspapers from the Netherlands Indies and Indonesia, see: https://github.com/KBNLresearch/gado2. Optical Character Recognition (OCR) resulted in high Character Error Rates (CER) due to the inferior quality of many scans. In contrast, HTR led to CERs below 0.5 percent thus increasing the efficiency of the NER engine. All uploaded files are free of errors and fully tagged. A relevant knowledge base of Indonesian persons, places and organisations is attached in json format for entity linking.
DOI: 10.5281/zenodo.4882962
title: Gado2: multilingual newspapers from the Netherlands Indies

description: This Handwritten Text Recognition (HTR) xml-page file dataset contains the ground truths of the Gado2 named entity processing application for newspapers from the Netherlands Indies and Indonesia, see: https://github.com/KBNLresearch/gado2. Optical Character Recognition (OCR) resulted in high Character Error Rates (CER) due to the inferior quality of many scans. In contrast, HTR led to CERs below 0.5 percent thus increasing the efficiency of the NER engine. All uploaded files are free of errors and fully tagged. A relevant knowledge base of Indonesian persons, places and organisations is attached in json format for entity linking.
DOI: 10.6084/m9.figshare.14611485
title: Single-cell RNA sequencing of freshly isolated bovine milk cells and cultured primary mammary epithelial cells

description: Files are supplementary to the paper "Single-cell RNA sequencing of freshly isolated bovine milk cells and cultured primary mammary epithelial cells".
DOI: 10.5281/zenodo.4731599
title: Crumpled few-layer graphene: connection between morphology and optical properties

description: The dataset contains tomographic TEM videoclips of crumpled few-layer graphene particles, corresponding volume-reconstructed objects, and 3D-MATLAB meshes as used in discrete dipole approximation simulations.
DOI: 10.5281/zenodo.4731598
title: Crumpled few-layer graphene: connection between morphology and optical properties

description: The dataset contains tomographic TEM videoclips of crumpled few-layer graphene particles, corresponding volume-reconstructed objects, and 3D-MATLAB meshes as used in discrete dipole approximation simulations.
DOI: 10.5281/zenodo.4767855
title: Companion dataset to an open-source toolbox for Multi-patient Intracerebral EEG Analysis (MIA)

description: Human Intracranial data collected in a picture naming task as described in : Dubarry, A.S., Llorens, A., Trébuchon, A., Carron, R., Liégeois-Chauvel, C., Bénar, C.G., Alario, F.X., 2017. Estimating Parallel Processing in a Language Task Using Single-Trial Intracerebral Electroencephalography. Psychological Science 28, 414–426. https://doi.org/10.1177/0956797616681296 This data was collected by Anais Llorens and organized as a MIA (open-source toolbox) database.
description: {"references": ["Dubarry et al 2017. Estimating Parallel Processing in a Language Task Using Single-Trial Intracerebral Electroencephalography"]}
DOI: 10.5281/zenodo.4767854
title: Companion dataset to an open-source toolbox for Multi-patient Intracerebral EEG Analysis (MIA)

description: Human Intracranial data collected in a picture naming task as described in : Dubarry, A.S., Llorens, A., Trébuchon, A., Carron, R., Liégeois-Chauvel, C., Bénar, C.G., Alario, F.X., 2017. Estimating Parallel Processing in a Language Task Using Single-Trial Intracerebral Electroencephalography. Psychological Science 28, 414–426. https://doi.org/10.1177/0956797616681296 This data was collected by Anais Llorens and organized as a MIA (open-source toolbox) database.
description: {"references": ["Dubarry et al 2017. Estimating Parallel Processing in a Language Task Using Single-Trial Intracerebral Electroencephalography"]}
DOI: 10.6084/m9.figshare.14805828
title: Supplementary Material for: Protective Effects of Vitamin E on Chemotherapy-Induced Peripheral Neuropathy: A Meta-Analysis of Randomized Controlled Trials

description: <b><i>Introduction:</i></b> Chemotherapy-induced peripheral neuropathy (CIPN) is a common symptom, but prophylactic measures cannot still be carried out effectively. In addition, the efficacy of vitamin E in preventing peripheral neurotoxicity caused by chemotherapy is inconclusive. Therefore, we collected the relevant randomized controlled trials (RCTs) and performed a meta-analysis to examine whether the vitamin E has a positive effect in CIPN. <b><i>Methods:</i></b> We searched PubMed, EMBASE, Cochrane, and other databases in December 2019 for eligible trials. Two reviewers conducted the analysis independently when studies were homogeneous enough. <b><i>Results:</i></b> Eight RCTs, involving 488 patients, were identified. Upon pooling these RCTs, patients who received vitamin E supplementation of 600 mg/day had a lower incidence of CIPN (risk ratio [RR] 0.31; 95% confidence interval [CI] 0.14–0.65; <i>p</i> = 0.002) than the placebo group. Vitamin E played a key role in decreasing the incidence of peripheral neuropathy in the cisplatin chemotherapy group (RR 0.28; 95% CI 0.14–0.54; <i>p</i> = 0.0001). Moreover, vitamin E supplementation significantly decreased patients’ sural amplitude after 3 rounds of chemotherapy (RR −2.66; 95% CI −5.09 to −0.24; <i>p</i> = 0.03) in contrast with that of placebo supplementation, while no significant difference was observed when patients were treated with vitamin E after 6 rounds of chemotherapy. In addition, the vitamin E-supplemented group had better improvement in the neurotoxicity score and lower incidence of reflexes and distal paraesthesias than the control group. <b><i>Conclusion:</i></b> Available data in this meta-analysis showed that vitamin E supplementation can confer modest improvement in the prevention of CIPN.
DOI: 10.6084/m9.figshare.14805828.v1
title: Supplementary Material for: Protective Effects of Vitamin E on Chemotherapy-Induced Peripheral Neuropathy: A Meta-Analysis of Randomized Controlled Trials

description: <b><i>Introduction:</i></b> Chemotherapy-induced peripheral neuropathy (CIPN) is a common symptom, but prophylactic measures cannot still be carried out effectively. In addition, the efficacy of vitamin E in preventing peripheral neurotoxicity caused by chemotherapy is inconclusive. Therefore, we collected the relevant randomized controlled trials (RCTs) and performed a meta-analysis to examine whether the vitamin E has a positive effect in CIPN. <b><i>Methods:</i></b> We searched PubMed, EMBASE, Cochrane, and other databases in December 2019 for eligible trials. Two reviewers conducted the analysis independently when studies were homogeneous enough. <b><i>Results:</i></b> Eight RCTs, involving 488 patients, were identified. Upon pooling these RCTs, patients who received vitamin E supplementation of 600 mg/day had a lower incidence of CIPN (risk ratio [RR] 0.31; 95% confidence interval [CI] 0.14–0.65; <i>p</i> = 0.002) than the placebo group. Vitamin E played a key role in decreasing the incidence of peripheral neuropathy in the cisplatin chemotherapy group (RR 0.28; 95% CI 0.14–0.54; <i>p</i> = 0.0001). Moreover, vitamin E supplementation significantly decreased patients’ sural amplitude after 3 rounds of chemotherapy (RR −2.66; 95% CI −5.09 to −0.24; <i>p</i> = 0.03) in contrast with that of placebo supplementation, while no significant difference was observed when patients were treated with vitamin E after 6 rounds of chemotherapy. In addition, the vitamin E-supplemented group had better improvement in the neurotoxicity score and lower incidence of reflexes and distal paraesthesias than the control group. <b><i>Conclusion:</i></b> Available data in this meta-analysis showed that vitamin E supplementation can confer modest improvement in the prevention of CIPN.
DOI: 10.6084/m9.figshare.14805744
title: Supplementary Material for: Using Electronic Medical Records of Nursing Care to Characterize Constipation in Patients with Intracerebral Hemorrhage

description: <b><i>Introduction:</i></b> Constipation is one of the common poststroke complications that directly affect the patients’ quality of life in patients with intracerebral hemorrhage (ICH), which has not been paid enough attention. <b><i>Objective:</i></b> This study investigates constipation’s clinical characteristics and its risk factors in ICH patients driven by the electronic medical records of nursing care. <b><i>Methods:</i></b> This retrospective chart review investigated patients with acute spontaneous ICH admitted at a tertiary care center from October 2010 to December 2018. Poststroke constipation was defined as a first stool passage occurring after 3 days postadmission and the use of enemas or laxatives after ICH. The associations between constipation present and potential factors were evaluated. <b><i>Results:</i></b> Of 1,748 patients, 408 (70.3% men, mean age 58 ± 14 years) patients with poststroke constipation were identified. After adjusting for potential confounding variables, the risk factors independently associated with poststroke constipation are admission Glasgow Coma Scale score (odds ratio [OR] 0.62, 95% confidence interval [CI] 0.44–0.88; <i>p</i> = 0.007), use of mechanical ventilation (OR 3.74, 95% CI 2.37–5.89, <i>p</i> &lt; 0.001), enteral nutrition (OR 2.82, 95% CI 1.85–4.30, <i>p</i> &lt; 0.001), hematoma evacuation (OR 2.10, 95% CI 1.40–3.16; <i>p</i> &lt; 0.001), opioid analgesics (OR 1.86, 95% CI 1.32–2.62; <i>p</i> &lt; 0.001), sedation (OR 1.83, 95% CI 1.20–2.77; <i>p</i> = 0.005), and vasopressors (OR 1.81, 95% CI 1.26–2.61; <i>p</i> = 0.001) in order. Similar associations were observed in the prespecified length of the stay subgroup. Patients with constipation were associated with a longer hospital stay length (2.24 days, 95% CI 1.43–3.05, <i>p</i> &lt; 0.001) but not with in-hospital mortality (OR 1.05, 95% CI 0.58–1.90, <i>p</i> = 0.871). <b><i>Conclusions:</i></b> Our findings suggested that risk factors influence the absence of constipation after ICH with the synergy of different weights. The occurrence of constipation likely affects a longer length of stay, but not in-hospital mortality. Future prospective investigations are warranted to validate our findings and identify the optimal management of constipation that may improve the quality of life in patients with ICH.
DOI: 10.6084/m9.figshare.14805744.v1
title: Supplementary Material for: Using Electronic Medical Records of Nursing Care to Characterize Constipation in Patients with Intracerebral Hemorrhage

description: <b><i>Introduction:</i></b> Constipation is one of the common poststroke complications that directly affect the patients’ quality of life in patients with intracerebral hemorrhage (ICH), which has not been paid enough attention. <b><i>Objective:</i></b> This study investigates constipation’s clinical characteristics and its risk factors in ICH patients driven by the electronic medical records of nursing care. <b><i>Methods:</i></b> This retrospective chart review investigated patients with acute spontaneous ICH admitted at a tertiary care center from October 2010 to December 2018. Poststroke constipation was defined as a first stool passage occurring after 3 days postadmission and the use of enemas or laxatives after ICH. The associations between constipation present and potential factors were evaluated. <b><i>Results:</i></b> Of 1,748 patients, 408 (70.3% men, mean age 58 ± 14 years) patients with poststroke constipation were identified. After adjusting for potential confounding variables, the risk factors independently associated with poststroke constipation are admission Glasgow Coma Scale score (odds ratio [OR] 0.62, 95% confidence interval [CI] 0.44–0.88; <i>p</i> = 0.007), use of mechanical ventilation (OR 3.74, 95% CI 2.37–5.89, <i>p</i> &lt; 0.001), enteral nutrition (OR 2.82, 95% CI 1.85–4.30, <i>p</i> &lt; 0.001), hematoma evacuation (OR 2.10, 95% CI 1.40–3.16; <i>p</i> &lt; 0.001), opioid analgesics (OR 1.86, 95% CI 1.32–2.62; <i>p</i> &lt; 0.001), sedation (OR 1.83, 95% CI 1.20–2.77; <i>p</i> = 0.005), and vasopressors (OR 1.81, 95% CI 1.26–2.61; <i>p</i> = 0.001) in order. Similar associations were observed in the prespecified length of the stay subgroup. Patients with constipation were associated with a longer hospital stay length (2.24 days, 95% CI 1.43–3.05, <i>p</i> &lt; 0.001) but not with in-hospital mortality (OR 1.05, 95% CI 0.58–1.90, <i>p</i> = 0.871). <b><i>Conclusions:</i></b> Our findings suggested that risk factors influence the absence of constipation after ICH with the synergy of different weights. The occurrence of constipation likely affects a longer length of stay, but not in-hospital mortality. Future prospective investigations are warranted to validate our findings and identify the optimal management of constipation that may improve the quality of life in patients with ICH.