DOI: 10.5061/dryad.kp064
title: Data from: Adverse events related to intravenous antibiotic therapy: a prospective observational study in the treatment of infective endocarditis

description: Objective: The goal of this prospective observational present study was to
 identify adverse events (AEs) related to the use of intravenous access
 sites for infective endocarditis (IE) treatment in a tertiary care
 hospital that can occur during patient care that cannot be attributed to
 the underlying disease and may result in lengthening of hospital stay or
 death. Design: This is an observational, analytical and prospective study
 on AEs resulting from the use of intravenous access sites in patients
 under antimicrobial treatment for IE. Patients enrolled in the
 International Collaboration on Endocarditis (ICE) study had their
 peripheral, short term central catheters (CVC) and peripherally inserted
 central catheters (PICC) monitored for AEs. Setting: Tertiary care
 hospital for cardiac surgery in Rio de Janeiro, Brazil. Patients: Patients
 over 18 years of age, hospitalized in 2009 and 2010 with definite criteria
 for IE by the modified Duke criteria were included. Main outcome measures:
 Adverse events related to intravenous catheters: erythema and
 infiltration, fever, obstruction, externalization and blood stream
 infection. Results: Thirty-seven episodes of IE in 35 patients were
 studied. Mean age was 44.32 ± 15.2 years; 22 (63%) were male. 253 vascular
 catheters were studied, 148 peripheral, 85 CVC (21 of which for
 haemodialysis) and 20 PICC. The most frequent AEs were “erythema” and
 “infiltration” for peripheral catheters, “fever” for CVCs, and
 “obstruction” and “externalization” for PICCs. The number of catheter-days
 was 360 for peripheral catheters, 1.156 for CVC and 420 for PICC. Kaplan
 Meier curves for CVC and PICC showed statistical difference for
 obstruction (p&lt;0.001) in PICCs. More bacteraemia occurred in CVC
 compared to PICC. Conclusion: The choice of intravenous access sites is
 critical in the treatment of IE. Close observation for adverse events and
 stricter implementation of infection control measures and better
 manipulation of catheters are suggested.
description: tabel hospitalization
 per episodeWe prepared a database
 in Access 2003 (Microsoft Corporation) for insertion of data collected.
 Later these data were transported to a table Excel (Microsoft Corporation)
 l. The patient-related variables were: age, sex, comorbidities (diabetes,
 hypertension, rheumatic fever, cancer, HIV and others), allergies, type of
 microorganism responsible for IE, type of valve at the beginning of the
 episode, presence of pacemaker or device as internal defibrillator,
 history of EI, source of acquisition of IE, echocardiographic data
 (evidence of vegetation, perforation, abscess and fistula), clinical data,
 date of commencement of treatment, total days planned for the end of
 treatment, antibiotics, indication for surgery and patient's
 fate.tabel venous
 accessWe prepared a database
 in Access 2003 (Microsoft Corporation) for insertion of data collected.
 Then the data were transported to a table of type Excel (Microsoft
 Corporation). The data collected were related to intravenous access:
 access types (peripheral, deep or hemodialysis), type of catheter, number
 of catheter lumens, number of insertion attempts, insertion date, date of
 removal, location of the insertion site, types of coatings (joint tape,
 hypoallergenic surgical tape, transparent dressing or tape),
 complications, cause for removal and professional responsible for the
 puncture.