cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.19886627.v1
title: Variability of retinopathy consequent upon novel mutations in LAMA1

description: Bi-allelic mutations in LAMA1 (laminin 1) (OMIM # 150320) cause Poretti-Boltshauser Syndrome (PTBHS), a rare non-progressive cerebellar dysplasia disorder with ophthalmic manifestations including oculomotor apraxia, high myopia, and retinal dystrophy. Only 38 variants, nearly all loss of function have been reported. Here, we describe novel LAMA1 variants and detailed retinal manifestations in two unrelated families. Whole-genome sequencing was conducted on three siblings of a consanguineous family with myopia and retinal dystrophy and on a child from an unrelated non-consanguineous couple. Clinical evaluation included full ophthalmic examination, detailed colour, autofluorescence retinal imaging, retinal optical coherence tomography (OCT), fluorescein angiography under anesthesia, and pattern and full-field electroretinography. Genetic analysis revealed a novel homozygous LAMA1 frameshift variant, c.1492del p.(Arg498Glyfs *25), in the affected siblings in family 1 and a novel frameshift c.3065del p.(Gly1022Valfs *2) and a deletion spanning exons 17–23 in an unrelated individual in family 2. Two of the three siblings and the unrelated child had oculomotor apraxia in childhood; none of the siblings had symptoms of other neurological dysfunction as adults. All four had myopia. The affected siblings had a qualitatively similar retinopathy of wide-ranging severity. The unrelated patient had a severe abnormality of retinal vascular development, which resulted in vitreous haemorrhage and neovascular glaucoma in the left eye and a rhegmatogenous retinal detachment in the right eye. This report describes the detailed retinal structural and functional consequences of LAMA1 deficiency in four patients from two families, and these exhibit significant variability with evidence of both retinal dystrophy and abnormal and incomplete retinal vascularisation.
DOI: 10.6084/m9.figshare.27934941.v1
title: grainbrain-paddy

description: grainbrain paddy
DOI: 10.6084/m9.figshare.5129188.v1
title: Supplementary Material for: Caffeine Prevents Hyperoxia-Induced Functional and Structural Lung Damage in Preterm Rabbits

description: <b><i>Background:</i></b> Caffeine is a commonly used drug for apnea of prematurity. It may, however, also have a beneficial effect on bronchopulmonary dysplasia (BPD), which is the most common complication of extreme preterm birth. <b><i>Objectives:</i></b> To study the inflammatory, structural and functional effects of caffeine in an animal model of BPD. <b><i>Methods:</i></b> Preterm New Zealand-Dendermonde rabbits (gestational day 28; term 31) were randomized to three groups: normoxia-placebo (N-P), hyperoxia-placebo (H-P) and hyperoxia-caffeine (H-C). Lung function was assessed on postnatal day 5, along with airway morphometry, vascular morphometry and a score observing airway inflammation. <b><i>Results:</i></b> Caffeine improved lung function by increasing lung volume [mean displaced volume N-P: 40.1 ± 6 ml/kg, H-P: 27.8 ± 8 ml/kg and H-C: 34.4 ± 7 ml/kg (p &lt; 0.05); total lung capacity: N-P: 1.17 ± 0.1 ml, H-P: 0.67 ± 0.1 ml and H-C: 1.1 ± 0.1 ml (p &lt; 0.05)], decreasing tissue damping [N-P: 2.7 ± 0.3 cm H<sub>2</sub>O/ml, H-P: 4.6 ± 0.6 cm H<sub>2</sub>O/ml and H-C: 3.2 ± 0.4 cm H<sub>2</sub>O/ml (p &lt; 0.05)], elastance [N-P: 9.3 ± 2.4 cm H<sub>2</sub>O/ml, H-P: 19.2 ± 7.4 cm H<sub>2</sub>O/ml and H-C: 10.7 ± 2 cm H<sub>2</sub>O/ml (p &lt; 0.05)] and compliance [N-P: 0.06 ± 0.01 cm H<sub>2</sub>O/ml, H-P: 0.054 ± 0.01 cm H<sub>2</sub>O/ml and H-C: 0.07 ± 0.013 cm H<sub>2</sub>O/ml (p &lt; 0.05)]. Caffeine also improved histology by decreasing alveolar size [linear intercepts; N-P: 83.6 ± 1.7, H-P: 82.9 ± 1.6 and H-C: 67.3 ± 1.4 (p &lt; 0.05)], increasing radial alveolar count (N-P: 6.6 ± 0.5, H-P: 5.7 ± 0.6 and H-C: 7.05 ± 0.5) and decreasing the acute inflammation score [N-P: 0.3 ± 0.1, H-P: 0.5 ± 0.1 and H-C: 0.4 ± 0.1 (p &lt; 0.05)]. <b><i>Conclusion:</i></b> In preterm rabbits, caffeine reduces the functional, architectural and inflammatory pulmonary changes induced by hyperoxia in the lung.
DOI: 10.6084/m9.figshare.14039459.v1
title: Data from Mayerl et al., J Text Studies. Increased viscosity of milk during infant feeding improves swallow safety through modifying sucking in an animal model

description: Data used in statistical analyses
DOI: 10.6084/m9.figshare.16975636.v1
title: Supplementary Data - Climate-induced forest dieback drives compositional changes in insect communities that are more pronounced for rare species

description: Supplementary Data I gives the complete list of MOTUs (with available taxonomy and DNA consensus) x Plot (with monthly samplings), Supplementary Data II gives the functional traits given per recovered Family, Supplementary Data III the geographic information on the sampled plots and Supplementary Data IV the tagged-primers used in this study.<br>
DOI: 10.6084/m9.figshare.25638624.v1
title: Tomo-CA

description: The result of tomography.
DOI: 10.6084/m9.figshare.5615731.v1
title: Data for "Integrating community assembly and biodiversity reveals new dimensions of ecosystem function: the Community Assembly and the Functioning of Ecosystems (CAFE) approach"

description: Data supporting the Ecology Letters publication entitled "Integrating community assembly and biodiversity to better understand ecosystem function: the Community Assembly and the Functioning of Ecosystems (CAFE) approach". <b></b><br>3 files are provided for the three case studies included in the paper. 1. Flory and Clay 20102. Casas et al. 20043. Thibault and Brown 2008<br>[R] code is available at https://github.com/ctkremer/priceTools.
DOI: 10.6084/m9.figshare.21971234.v1
title: data_grow

description: Pig grow data for genomic selection, containing three breed (Duroc, Landrace and Yorkshire).
DOI: 10.6084/m9.figshare.23707848.v1
title: Supplementary Material for: The Ghent Psychotherapy Study (GPS): a pragmatic, stratified, randomized parallel trial into the differential efficacy of psychodynamic and cognitive-behavioral interventions in dependent and self-critical depressive patients

description: Introduction: Different types of psychotherapy are effective for treating major depressive disorder across groups yet show large within-group differences. Patient personality style is considered a potentially useful variable for treatment matching. Objective: This study is the first experimental test of the interaction between therapeutic approach and patients’ dependent versus self-critical personality styles. Methods: A pragmatic stratified parallel trial was carried out with 100 adult patients diagnosed with DSM-IV-TR Major Depressive Disorder. They were randomly assigned to short-term (16–20 sessions) Cognitive Behavioral Therapy (CBT) or Short-Term Psychodynamic Psychotherapy (STPP). Patients were assessed at baseline, during therapy, post therapy, and 3 and 6-month follow-up. Primary outcome is depression severity measured by the Hamilton Rating Scale for Depression post treatment. Primary analysis was by intention to treat. This trial is registered with the ISRCTN registry (www.isrctn.com), number ISRCTN17130982. Results: The intention-to-treat sample consisted of 100 participants; 40 with self-critical and 60 with dependent personality styles were randomized to either CBT (n=50) or STPP (n=50). We observed no interaction effect (–0·34 (–6·14,5·46)) between therapy and personality style and found no evidence for a difference in effectiveness between the treatments in general in terms of symptom reduction and maintained benefits at 6-month follow-up. Conclusion: We found no evidence that dependent versus self-critical personality styles moderate the relation between treatment and outcome in depression. Research using individual patient data could gain further insight into why specific therapeutic approaches work better for specific patients.
DOI: 10.6084/m9.figshare.27223023.v1
title: Supplementary Material for: Artificial intelligence-driven skin aging simulation as a novel skin cancer prevention

description: Introduction: 
Skin cancer, a prevalent cancer type among fair-skinned patients globally, poses a relevant public health concern due to rising incidence rates. Ultraviolet (UV) radiation poses a major risk factor for skin cancer. However intentional tanning associated with sunburns remains a common practice, notably among female adults Appropriate prevention campaigns targeting children and adolescents are needed to improve sun-protection behavior particularly in these age groups. The aim of our study is to investigate if an AI-based simulation of facial skin aging can enhance sun-protection behavior in female adults.
Methods: 
In this single-center prospective observational pilot study at Department of Dermatology at the University Hospital of Basel, we took photographs of healthy young females’ faces with a VISIA‐CR camera (Canfield Scientific Inc., Parsippany, New Jersey, Version 8.2) between February to March 2021. Digital images were performed in three angles (straight, left 45°, right 45°). All participants received an AI-based simulation of their facial skin with continuous aging to 80 years. A newly created anonymous questionnaire capturing participants’ sociodemographic data and also tanning and sun-protection behavior was completed in pre- and post-aging simulation. To observe long-term effects, a 2-year follow-up was conducted between March to April 2023.
Results: 
The 60 participants (mean age 23.6±2.5 years) evaluated the importance of sun-protection significantly higher after skin aging simulation with VISIA-CR camera (p&lt;0.0001; 95%-CI:8.2-8.8). Post-intervention, 91.7% (55/60) of the females were motivated to reduce UV exposure and to intensify UV protection in the future since the individual UV-dependent risk was perceived significantly higher (p&lt;0.001; 95%-CI: 5.9-6.7). At two-year follow-up, 96% (24/25) indicated persistent effort reducing UV exposure. The preference for SPF50+ sunscreen increased to 46.7% (28/65) directly after the skin-aging simulation and continued to rise up to 60.0% (15/25) after two years.
Conclusions: 
Our data emphasize the potential of AI-assisted photo-aging interventions to enhance motivation for UV protection in the short and the long term We encourage that different age and gender groups are addressed in a personalized, generation-specific manner with the appropriate media and by considering the Hawthorne effect. Campaigns with visual AI support can improve the intent of cancer-preventative behavior.
DOI: 10.6084/m9.figshare.28740659.v1
title: Data, code and analysis process

description: Sense of direction is a crucial component of spatial orientation, particularly in unfamiliar environments, where normal sense of direction is conducive to individuals’ effective arrival at their destinations. However, the characteristics of individuals with impaired sense of direction, compared to those with a normal sense of direction, in terms of spatial orientation remain insufficiently understood. In this study, we aim to explore the differences in spatial orientation between individuals with impaired sense of direction and those with normal sense of direction through an outdoor wayfinding experiment in an unfamiliar environment, focusing on two aspects: spatial visual attention and spatial knowledge acquisition. The results indicate that, compared with individuals with normal sense of direction, those with impaired sense of direction exhibited narrower scope of visual search, insufficient information acquisition, reduced efficiency in visual information processing, and uneven distribution of spatial visual attention towards the ordinary and prominent landmarks they pay attention to. Regarding spatial knowledge acquisition, individuals with impaired sense of direction struggled to effectively identify spatial relationships, had a poor spatial memory, existed different characteristics in spatial thinking. This study is helpful to understand the spatial cognitive traits of individuals with impaired sense of direction.
DOI: 10.6084/m9.figshare.27829143.v1
title: Characterization of influenza H5Nx Candidate Vaccine Viruses formulations

description: We presented data on the production and characterization of three distinct monovalent antigens of H5Nx Candidate Vaccine Viruses (CVVs) from clades 2.3.2.1c (NIBRG-301), 2.3.4 (IBCDC-RG6), and 2.3.4.4b (IDCDC-RG71A). For simplicity, we referred to them as Duck/Vietnam, Anhui, and Astrakhan, respectively. Files containing raw data from the results of IgG antibodies, Hemagglutination Inhibition, Microneutralization titers, animal weight, and the statistical analysis were uploaded.We also showed data on the percentage of identity of H5 sequences –globular domain – among i) H5N1 isolates (birds and humans) and the antigenic prototypes of available H5N1, H5N6, and H5N8 CVVs with potency-testing reagents; and ii) the three CVVs produced and an human-licensed H5N1 vaccine (IDCDC-RG2).The results and conclusions from the analysis will be submitted for publication: “Production and immune response against pandemic influenza candidate vaccines as preparedness against the circulating H5N1 influenza viruses”. Raw data were generated using The Influenza Virus Resource at the NCBI, GISAID- EpiFlu, SnapGene, NCBI BLAST, Microsoft Excel, and GraphPad Prism Software, version 5.03 for Windows.
DOI: 10.6084/m9.figshare.9742145.v1
title: Supplementary Material for: Impact of Simulated Hyperventilation and Periodic Breathing on Sympatho-Vagal Balance and Hemodynamics in Patients with and without Heart Failure

description: <b><i>Background:</i></b> The effects of hyperventilation and hyperventilation in the context of periodic breathing (PB) on sympatho-vagal balance (SVB) and hemodynamics in conditions of decreased cardiac output and feedback resetting, such as heart failure (HF) or pulmonary arterial hypertension (PAH), are not completely understood. <b><i>Objectives:</i></b> To investigate the effects of voluntary hyperventilation and simulated PB on hemodynamics and SVB in healthy subjects, in patients with systolic HF and reduced or mid-range ejection fraction (HFrEF and HFmrEF) and in patients with PAH. <b><i>Methods:</i></b> Study participants (<i>n</i> = 20 per group) underwent non-invasive recording of diastolic blood pressure, heart rate variability (HRV), baroreceptor-reflex sensitivity (BRS), total peripheral resistance index (TPRI) and cardiac index (CI). All measurements were performed at baseline, during voluntary hyperventilation and during simulated PB with different length of the hyperventilation phase. <b><i>Results:</i></b> In healthy subjects, voluntary hyperventilation led to a 50% decrease in the mean BRS slope and a 29% increase in CI compared to baseline values (<i>p</i> &lt; 0.01 and <i>p</i> &lt; 0.05). Simulated PB did not alter TPRI or CI and showed heterogeneous effects on BRS, but analysis of dPBV revealed decreased sympathetic drive in healthy volunteers depending on PB cycle length (<i>p</i> &lt; 0.05). In HF patients, hyperventilation did not affect BRS and TPRI but increased the CI by 10% (<i>p</i> &lt; 0.05). In HF patients, simulated PB left all of these parameters unaffected. In PAH patients, voluntary hyperventilation led to a 15% decrease in the high-frequency component of HRV (<i>p</i> &lt; 0.05) and a 5% increase in CI (<i>p</i> &lt; 0.05). Simulated PB exerted neutral effects on both SVB and hemodynamic parameters. <b><i>Conclusions:</i></b> Voluntary hyperventilation was associated with sympathetic predominance and CI increase in healthy volunteers, but only with minor hemodynamic and SVB effects in patients with HF and PAH. Simulated PB had positive effects on SVB in healthy volunteers but neutral effects on SVB and hemodynamics in patients with HF or PAH.
DOI: 10.6084/m9.figshare.26314909.v1
title: STC miRNA-seq.xlsx

description: STC miRNA-seq
DOI: 10.6084/m9.figshare.11365115.v1
title: Supplementary Material for: Research Themes and Trends in Ten Top-Ranked Nephrology Journals: A Text Mining Analysis

description: <b><i>Background:</i></b> Nephrology research is expanding, and harnessing the much-needed information and data for the practice of evidence-based medicine is becoming more challenging. In this study, we used the natural language processing and text mining approach to mitigate some of these challenges. <b><i>Methods:</i></b> We analyzed 17,412 abstracts from the top-10 nephrology journals over 10 years (2007–2017) by using latent semantic analysis and topic analysis. <b><i>Results:</i></b> The analyses revealed 10 distinct topics (T) for nephrology research ranging from basic science studies, using animal modeling (T-1), to dialysis vascular access-related issues ­(T-10). The trend analyses indicated that while the majority of topics stayed relatively stable, some of the research topics experienced increasing popularity over time such as studies focusing on mortality and survival (T-4) and Patient-related Outcomes and Perspectives of Clinicians (T-5). However, some research topics such as studies focusing on animal modeling (T-1), predictors of acute kidney injury, and dialysis access (T-10) exhibited a downward trend. <b><i>Conclusion:</i></b> Stakeholders of nephrology research may use these trends further to develop priorities and enrich the research agenda for the future.
DOI: 10.6084/m9.figshare.9932162.v1
title: Binary files for the ecco-v4-py Python package.

description: Binary files for the ecco-v4-py Python package. <br><br>basin mask for llc90 grid basins.meta, basins.data <br><br>wet/dry mask for llc90 grid: <br> hFacC.data, hFacC.meta<br>example 3D state variable field: <br> state_3d_set1.0000000732.data, <br> state_3d_set1.0000000732.meta
DOI: 10.6084/m9.figshare.21119641.v1
title: Supplementary Material for: Long-term trends in obesity prevalence by socio-economic group in five European countries and the USA: The relevance of the diffusion of innovations theory

description: Abstract Introduction: Cross-national comparison suggests that the timing of the obesity epidemic differs across socio-economic groups (SEGs). Similar to the smoking epidemic, these differences might be described by the diffusion of innovations theory, which states that health behaviours diffuse from higher to lower SEGs. However, the applicability of the diffusion of innovations theory to long-term time trends in obesity by SEG is unknown. We studied long-term trends in the obesity prevalence by socio-economic group in England, France, Finland, Italy, Norway, and the USA and examined whether trends are described by the diffusion of innovations theory. Methods: Obesity prevalence from 1978 to 2019 by educational level, sex, and age group (25+) from health surveys were harmonised, age-standardised, Loess-smoothed, and visualised. Prevalence rate differences were calculated and segmented regression was performed to obtain annual percentage changes, which were compared over time and across SEGs. Results: Obesity prevalence among lower educated has exceeded that of higher educated groups, except among USA men, in all countries throughout the study period. A comparable increase across educational levels was observed until approximately 2000. Recently, obesity prevalence stagnated among higher educated groups in Finland, France, Italy, and Norway, and lower educated groups in England and the USA. Discussion: Recent trends in obesity prevalence by SEG are mostly in line with the diffusion of innovations theory, however, no diffusion from higher to lower SEGs at the start of the epidemic was found. The stagnation among higher SEGs but not lower SEGs suggests that the latter will likely experience the greatest future burden.
DOI: 10.6084/m9.figshare.24073014.v1
title: Digital divide data extraction

description: Data of China Family Tracking Survey (CFPS) from 2010 to 2018, CFPS data is the data organized and published by the China Social Science Survey Center of Peking University. CFPS data reflects the changes of China's society, economy and education by tracking and investigating the data of individuals, families and communities. CFPS has a total of 7 periods of open data. Due to the lack of relevant sector data in 2012 and 2020, five periods of data in 2010, 2011, 2014, 2016 and 2018 are selected as research samples. The data are processed as follows: 1. The family member questionnaire, the family economic questionnaire and the personal self-response questionnaire are combined horizontally. 2. The data of the five periods were vertically combined, and the individual household accounts in the household economic questionnaire were used to select rural household accounts as samples. 3. Select the central and western regions as the research samples, divide the experimental group and the control group according to the policy implementation pilot, and retain the relevant variables. 4. Remove missing values and outliers of relevant variables. Finally, 15,869 farmers were studied.
DOI: 10.6084/m9.figshare.28723142.v1
title: Supplementary Material for: Health implications associated with fat-free mass: phenome-wide Mendelian randomization study

description: Introduction: Fat-free mass (FFM) is a critical component of the human body, with implications for various diseases. 
Methods:We conducted a comprehensive analysis integrating a phenome-wide association study (PheWAS), a two-sample Mendelian randomization (MR) analysis, and a systematic review to investigate the associations between FFM and health outcomes.
Results: PheWAS identified 183 phenotypes enriched for FFM associations, including diseases, body composition, and lifestyle factors. Two-sample MR analysis using FinnGen and UK biobank dataset revealed significant associations between genetically determined FFM and 36 disease outcomes, including cardiovascular diseases, metabolic disorders, and musculoskeletal conditions. The mediation MR analysis indicates that FFM indirectly influences the levels of five biomarkers through visceral adipose tissue. A systematic review identified consistent associations between FFM and several diseases, including type 2 diabetes and cervical disc disorders. Moreover, new associations such as low back pain and ovarian cancer were discovered. 
Conclusion: These findings challenge the conventional notion of FFM as a protective factor in health, suggesting that higher FFM levels may be linked to an increased risk of various diseases.. Further clinical studies are warranted to validate these findings and elucidate the underlying mechanisms.
DOI: 10.6084/m9.figshare.5797434.v1
title: Analysis of skin pigmentation

description: Correlation analysis for skin color (L*), melanocytes ratio and melanin concentration