cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.20748082
title: Supplementary Material for: Efficacy and Safety of Lanreotide Autogel and Temozolomide Combination Therapy in Progressive Thoracic Neuroendocrine Tumors (carcinoid): Results from the Phase 2 ATLANT Study

description: Introduction: Lanreotide autogel (LAN) and temozolomide (TMZ) are guidelines-recommended monotherapies for thoracic neuroendocrine tumors (carcinoids; T-NETs) but prospective data for both combined and monotherapies are lacking. ATLANT (NCT02698410) evaluated efficacy and safety of LAN/TMZ in progressive T-NETs. Methods: ATLANT was a 12-month, Italian, phase 2, single-arm, open-label, multicenter pilot study. Eligible patients had unresectable, locally-advanced/metastatic, well-/moderately-differentiated T-NETs with radiological progression. Patients received subcutaneous LAN 120 mg every 28 days and oral TMZ 250 mg/day for 5 consecutive days every 28-day cycle. Main endpoints: disease control rate (DCR) at 9 months (primary; investigator-assessed), median progression-free survival (PFS), biomarkers and safety. Results: Patients: n=40; 60% male. Primary tumor site: lung (90%); thymus (10%). Carcinoid type: typical (20.0%), atypical (52.5%). DCR at 9 months was 35.0% (95% confidence interval [CI] 20.63–51.68) (non-acceptability threshold ≤10%, p&lt;0.0001; not significantly above clinically relevant threshold ≥30%, p=0.2968). DCR between 7.5 and 10.5 months (sensitivity analysis) was 45.0% (95%CI 29.26–61.51) and clinically relevant (p=0.0320 at ≥30% threshold). Median PFS was 37.1 (95%CI 24.1–52.9) weeks. No association was observed between biomarker variations (chromogranin A, neuron-specific enolase, somatostatin receptor type-2, Ki-67, 6-O-methylguanine-DNA-methyl-transferase) and DCR or PFS. Most patients (97.5%) had treatment-emergent adverse events (TEAEs); 72.5% had treatment-related TEAEs. TEAEs were mainly grade 1/2. No unanticipated TEAEs were reported. Conclusions: This study showed that LAN/TMZ combination has promising efficacy in progressive T-NETs, and was well tolerated. Larger studies are warranted to support the clinical benefits of LAN/TMZ in patients with T-NETs.
DOI: 10.6084/m9.figshare.20748082.v2
title: Supplementary Material for: Efficacy and Safety of Lanreotide Autogel and Temozolomide Combination Therapy in Progressive Thoracic Neuroendocrine Tumors (carcinoid): Results from the Phase 2 ATLANT Study

description: Introduction: Lanreotide autogel (LAN) and temozolomide (TMZ) are guidelines-recommended monotherapies for thoracic neuroendocrine tumors (carcinoids; T-NETs) but prospective data for both combined and monotherapies are lacking. ATLANT (NCT02698410) evaluated efficacy and safety of LAN/TMZ in progressive T-NETs. Methods: ATLANT was a 12-month, Italian, phase 2, single-arm, open-label, multicenter pilot study. Eligible patients had unresectable, locally-advanced/metastatic, well-/moderately-differentiated T-NETs with radiological progression. Patients received subcutaneous LAN 120 mg every 28 days and oral TMZ 250 mg/day for 5 consecutive days every 28-day cycle. Main endpoints: disease control rate (DCR) at 9 months (primary; investigator-assessed), median progression-free survival (PFS), biomarkers and safety. Results: Patients: n=40; 60% male. Primary tumor site: lung (90%); thymus (10%). Carcinoid type: typical (20.0%), atypical (52.5%). DCR at 9 months was 35.0% (95% confidence interval [CI] 20.63–51.68) (non-acceptability threshold ≤10%, p&lt;0.0001; not significantly above clinically relevant threshold ≥30%, p=0.2968). DCR between 7.5 and 10.5 months (sensitivity analysis) was 45.0% (95%CI 29.26–61.51) and clinically relevant (p=0.0320 at ≥30% threshold). Median PFS was 37.1 (95%CI 24.1–52.9) weeks. No association was observed between biomarker variations (chromogranin A, neuron-specific enolase, somatostatin receptor type-2, Ki-67, 6-O-methylguanine-DNA-methyl-transferase) and DCR or PFS. Most patients (97.5%) had treatment-emergent adverse events (TEAEs); 72.5% had treatment-related TEAEs. TEAEs were mainly grade 1/2. No unanticipated TEAEs were reported. Conclusions: This study showed that LAN/TMZ combination has promising efficacy in progressive T-NETs, and was well tolerated. Larger studies are warranted to support the clinical benefits of LAN/TMZ in patients with T-NETs.
DOI: 10.6084/m9.figshare.20748082.v1
title: Supplementary Material for: Efficacy and Safety of Lanreotide Autogel and Temozolomide Combination Therapy in Progressive Thoracic Neuroendocrine Tumors (carcinoid): Results from the Phase 2 ATLANT Study

description: Introduction: Lanreotide autogel (LAN) and temozolomide (TMZ) are guidelines-recommended monotherapies for thoracic neuroendocrine tumors (carcinoids; T-NETs) but prospective data for both combined and monotherapies are lacking. ATLANT (NCT02698410) evaluated efficacy and safety of LAN/TMZ in progressive T-NETs. Methods: ATLANT was a 12-month, Italian, phase 2, single-arm, open-label, multicenter pilot study. Eligible patients had unresectable, locally-advanced/metastatic, well-/moderately-differentiated T-NETs with radiological progression. Patients received subcutaneous LAN 120 mg every 28 days and oral TMZ 250 mg/day for 5 consecutive days every 28-day cycle. Main endpoints: disease control rate (DCR) at 9 months (primary; investigator-assessed), median progression-free survival (PFS), biomarkers and safety. Results: Patients: n=40; 60% male. Primary tumor site: lung (90%); thymus (10%). Carcinoid type: typical (20.0%), atypical (52.5%). DCR at 9 months was 35.0% (95% confidence interval [CI] 20.63–51.68) (non-acceptability threshold ≤10%, p&lt;0.0001; not significantly above clinically relevant threshold ≥30%, p=0.2968). DCR between 7.5 and 10.5 months (sensitivity analysis) was 45.0% (95%CI 29.26–61.51) and clinically relevant (p=0.0320 at ≥30% threshold). Median PFS was 37.1 (95%CI 24.1–52.9) weeks. No association was observed between biomarker variations (chromogranin A, neuron-specific enolase, somatostatin receptor type-2, Ki-67, 6-O-methylguanine-DNA-methyl-transferase) and DCR or PFS. Most patients (97.5%) had treatment-emergent adverse events (TEAEs); 72.5% had treatment-related TEAEs. TEAEs were mainly grade 1/2. No unanticipated TEAEs were reported. Conclusions: This study showed that LAN/TMZ combination has promising efficacy in progressive T-NETs, and was well tolerated. Larger studies are warranted to support the clinical benefits of LAN/TMZ in patients with T-NETs.
DOI: 10.6069/42nm-m522
title: Mass spectrometry-driven discovery of neuropeptides mediating nictation behavior of nematodes

description: Very little is known about the genetic modulation of nictation, a host-finding strategy used by infective juveniles of many pathogenic nematodes, as well as a phoretic strategy of Caenorhabditis elegans dauers. We here use a mass spectrometry-driven approach to find neuropeptides involved in the modulation of this behavior. We identified 126 neuropeptides in infective juveniles of the commercially relevant entomopathogenic nematode Steinernema carpocapsae, 75 of which have orthologs in the model organism C. elegans. To prioritize candidates for causality testing in light of the stage-restricted nictation behavior, we developed a targeted approach to carry out quantitative neuropeptidomics measurements in C. elegans. Our results show that virtually all 164 quantified neuropeptides are more abundant in dauers compared to L3 juveniles. Amongst these, we identify at least the neuropeptide genes flp-7 and flp-11 as novel regulators of nictation.
DOI: 10.5281/zenodo.7382905
title: Data for: Luo et al., Expiratory aerosol pH: the overlooked driver of airborne virus inactivation, Environmental Science and Technology, 10.1021/acs.est.2c05777

description: <strong>Experimental data </strong> This folder contains the experimental data to the figures shown in the main manuscript and Supporting Information. Figures 1 and S3 (inactivation curves for IAV, SARS-CoV-2 and HCoV-229E) Figure 1 (rate constants) Figure 2 (EDB analysis of SLF) Figure S1A (zetasizer analysis to measure virus aggregation) Figure S1B (renilla and plaque assay data for viruses exposed to pH 5, 6 and 7) Figure S4A (EDB analysis of different SLF samples; raw data) Figure S4Amean (EDB analysis of different SLF samples; mean values) Figure S5 (EDB analysis of nasal mucus) Figure S8 (EDB analysis of slow crystal growth stage of SLF and nasal mucus) Figure S13 and S14 (literature data on inactivation of IAV and SARS-CoV-2 in aerosol particles)
DOI: 10.5281/zenodo.7382904
title: Data for: Luo et al., Expiratory aerosol pH: the overlooked driver of airborne virus inactivation, Environmental Science and Technology, 10.1021/acs.est.2c05777

description: <strong>Experimental data </strong> This folder contains the experimental data to the figures shown in the main manuscript and Supporting Information. Figures 1 and S3 (inactivation curves for IAV, SARS-CoV-2 and HCoV-229E) Figure 1 (rate constants) Figure 2 (EDB analysis of SLF) Figure S1A (zetasizer analysis to measure virus aggregation) Figure S1B (renilla and plaque assay data for viruses exposed to pH 5, 6 and 7) Figure S4A (EDB analysis of different SLF samples; raw data) Figure S4Amean (EDB analysis of different SLF samples; mean values) Figure S5 (EDB analysis of nasal mucus) Figure S8 (EDB analysis of slow crystal growth stage of SLF and nasal mucus) Figure S13 and S14 (literature data on inactivation of IAV and SARS-CoV-2 in aerosol particles)
DOI: 10.6084/m9.figshare.21695657
title: data_for_ox_deox_paper_reviewers.tar.gz

description: data, models and scripts aimed to ox/deox classification paper reviewers.
DOI: 10.34740/kaggle/dsv/4687839
title: Monthly Employee Demographic Info
DOI: 10.25403/upresearchdata.21640094
title: Analysis of germination, early seedling growth, field survival and tree growth between different seed sizes and seed pre-treatments for Pinus elliottii seed

description: The datasets consists of data collected from three trials (laboratory, nursery and field trial) to determine the effect of seed size and seed pre-treatment on germination, early seedling growth, field survival and growth of Pinus elliottii seed. The data was analyzed using VSN International (2022). GenStat <em>for Windows</em> 22nd Edition. VSN International, Hemel Hempstead, UK. The data (including graphs) was managed using MS Excel 2016.
DOI: 10.25403/upresearchdata.21640094.v1
title: Analysis of germination, early seedling growth, field survival and tree growth between different seed sizes and seed pre-treatments for Pinus elliottii seed

description: The datasets consists of data collected from three trials (laboratory, nursery and field trial) to determine the effect of seed size and seed pre-treatment on germination, early seedling growth, field survival and growth of Pinus elliottii seed. The data was analyzed using VSN International (2022). GenStat <em>for Windows</em> 22nd Edition. VSN International, Hemel Hempstead, UK. The data (including graphs) was managed using MS Excel 2016.
DOI: 10.6084/m9.figshare.21695666
title: RCS data for numerical testcases

description: Includes RCS data for canonical testcases in numerical methods to solve the time-domain Maxwell's equations.
DOI: 10.5281/zenodo.7413878
title: Quartet of familiar males – 16p11.2 Del mouse strain – 2 WT + 2 Del/+ - M4

description: We monitored the individual and social behaviours of each quartet of mice over three days and nights in the Live Mouse Tracker system (LMT, plugin 931; de Chaumont et al. 2019 Nat. Biomed. Engin.). This system tracks individually mice living in a group over several days and nights and extracts automatically the number, total duration and mean duration of more than thirty behavioural events describing the posture of the mouse, the types of social contacts, the dynamic social approach and escapes and complex social groupings (see de Chaumont et al. 2019 Nat. Biomed. Engin.). In this system, the four mice (10-14 weeks of age; 2 WT mice and 2 Del/+ mice) from the same housing cage (housed together from weaning on) were left undisturbed for 71 hours in a large transparent Plexiglas cage (50 x 50 x 40 cm), with fresh bedding, a house (width: 100 mm, depth: 75 mm, height: 40 mm) in red Plexiglas, 6 dental cotton rolls as well as food and water ad libitum. Light/dark cycle and temperature conditions were similar to those of the housing room (12/12h light/dark, lights on at 07:00 AM, 100 lux when the lights were on). Each recording session started between 03:00 and 04:00 PM. At the end of the session, mice were placed back in their home cage and the LMT setup was cleaned with soap water and dried with paper towels. The upload includes the sqlite database from LMT (processed).
DOI: 10.5281/zenodo.7413877
title: Quartet of familiar males – 16p11.2 Del mouse strain – 2 WT + 2 Del/+ - M4

description: We monitored the individual and social behaviours of each quartet of mice over three days and nights in the Live Mouse Tracker system (LMT, plugin 931; de Chaumont et al. 2019 Nat. Biomed. Engin.). This system tracks individually mice living in a group over several days and nights and extracts automatically the number, total duration and mean duration of more than thirty behavioural events describing the posture of the mouse, the types of social contacts, the dynamic social approach and escapes and complex social groupings (see de Chaumont et al. 2019 Nat. Biomed. Engin.). In this system, the four mice (10-14 weeks of age; 2 WT mice and 2 Del/+ mice) from the same housing cage (housed together from weaning on) were left undisturbed for 71 hours in a large transparent Plexiglas cage (50 x 50 x 40 cm), with fresh bedding, a house (width: 100 mm, depth: 75 mm, height: 40 mm) in red Plexiglas, 6 dental cotton rolls as well as food and water ad libitum. Light/dark cycle and temperature conditions were similar to those of the housing room (12/12h light/dark, lights on at 07:00 AM, 100 lux when the lights were on). Each recording session started between 03:00 and 04:00 PM. At the end of the session, mice were placed back in their home cage and the LMT setup was cleaned with soap water and dried with paper towels. The upload includes the sqlite database from LMT (processed).
DOI: 10.6084/m9.figshare.21695675
title: Coralline algal abundance & richness.xls

description: coralline algal abundance and richness in Well CK2.
DOI: 10.6084/m9.figshare.21695675.v1
title: Coralline algal abundance & richness.xls

description: coralline algal abundance and richness in Well CK2.
DOI: 10.6084/m9.figshare.21694727
title: Genome of the Northern pig-tailed macaque (Macaca leonina)

description: Here, we released the genome of Northern pig-tailed macaque (Macaca leonina), which covered three files (genome assembly, gene annotation and CDS). These files were named by NPM_genome1.0.fa.gz, NPM_genome1.0.gff and NPM_genome1.0.cds, respectively.
DOI: 10.6084/m9.figshare.21694727.v1
title: Genome of the Northern pig-tailed macaque (Macaca leonina)

description: Here, we released the genome of Northern pig-tailed macaque (Macaca leonina), which covered three files (genome assembly, gene annotation and CDS). These files were named by NPM_genome1.0.fa.gz, NPM_genome1.0.gff and NPM_genome1.0.cds, respectively.
DOI: 10.6084/m9.figshare.21692894
title: Primate Genome Annotation

description: Herein, we uploaded the compressed file titled "Primate_Genome_Annotation_GFF_Files.zip". In this zip file, we described the genome annotations (GFF files) of 27 primate long-read sequencing genomes. Meanwhile, their genome assemblies were uploaded to the NCBI assembly database. For each gff annotation file of primate genomes, it was named by the layout, species_name.annotation.gff.
DOI: 10.34740/kaggle/dsv/4687899
title: YouTube Trending Video Dataset (updated daily)
DOI: 10.21942/uva.16929505.v3
title: Dataset belonging to Siebers et al. (2022) Explaining variation in adolescents' social media-related distraction: The role of social connectivity and disconnectivity factors

description: The codebook, preregistration, syntaxes, and online supplemental materials can be found on the Open Science Framework (OSF) at https://osf.io/54uzf/.<br>For more information, please contact the authors via t.siebers@uva.nl or info@project-awesome.nl.
DOI: 10.7910/dvn/cft8z7
title: Korneyev A. V. Industrial control systems and procedures for providing comprehensive security of “green energy” facilities in the future digital economy. – Text // Europe – Energy – Climate: The Quest for the Clean Energy Transition in the EU / Ed. by A. E. Rządkowska ; European Solar Network (ESN), International Solar Energy Society (ISES). – [2nd edition, revised and enlarged]. – Brussels : European Solar Network Press, November 2021. – P. 1090–1109.

description: The process of development of existing and projected future integrated “green power” systems, including traditional thermal power plants, hydroelectric power plants, nuclear power plants and heterogeneous renewable energy sources, is characterized by various types and operating modes of generating facilities, involving complex problems of compatibility and synchronization of parallel energy and control information flows. These trends put on the agenda the new complicated problems of ensuring the sustainability for practical controlled operation of heterogeneous power supply systems in the current context of a qualitative transition from preceding manual local operations to fundamentally new levels of automated dispatch remote control mode, industrial training and technological culture. The key role here is played by new digital industrial control systems and situational control rooms and centers, which integrate information flows from a variety of sources in order to analyze current events, forecast their development and analyze possible consequences of management decisions decisions made by before the possible accidents. The text of the chapter includes consideration of: energy security, green power, industrial control systems, SCADA, circular economies, functional protection, intensive personnel training.
DOI: 10.6084/m9.figshare.21695729
title: Figures.zip

description: Figures and Additional files.
DOI: 10.6084/m9.figshare.21695729.v1
title: Figures.zip

description: Figures and Additional files.
DOI: 10.21942/uva.16929505
title: Dataset belonging to Siebers et al. (2022) Explaining variation in adolescents' social media-related distraction: The role of social connectivity and disconnectivity factors

description: The codebook, preregistration, syntaxes, and online supplemental materials can be found on the Open Science Framework (OSF) at https://osf.io/54uzf/.<br>For more information, please contact the authors via t.siebers@uva.nl or info@project-awesome.nl.
DOI: 10.21942/uva.16929505.v4
title: Dataset belonging to Siebers et al. (2022) Explaining variation in adolescents' social media-related distraction: The role of social connectivity and disconnectivity factors

description: The codebook, preregistration, syntaxes, and online supplemental materials can be found on the Open Science Framework (OSF) at https://osf.io/54uzf/.<br>For more information, please contact the authors via t.siebers@uva.nl or info@project-awesome.nl.
DOI: 10.21942/uva.16929505.v5
title: Dataset belonging to Siebers et al. (2022) Explaining variation in adolescents' social media-related distraction: The role of social connectivity and disconnectivity factors

description: The codebook, preregistration, syntaxes, and online supplemental materials can be found on the Open Science Framework (OSF) at https://osf.io/54uzf/.<br>For more information, please contact the authors via t.siebers@uva.nl or info@project-awesome.nl.
DOI: 10.23729/79b3286f-18ff-49ed-8645-b98b558a48d3
title: Hazarctic preview

description: Pieces of rock in glacial till which were sampled from excavations during acid sulphide soil mapping (EU project HazArctic http://projects.gtk.fi/HazArctic). Sample IDs: EN-ASBO-2021-16.6 from the Oulu district near Jäälinjärvi Pulmankijärvi 2021 from Inari. Preview of PAS-dataset https://doi.org/10.23729/605d4a9d-187c-4083-a6eb-548193757a78
DOI: 10.5281/zenodo.7115115
title: Defining objective clusters for rabies virus sequences using affinity propagation clustering

description: Rabies is caused by lyssaviruses, and is one of the oldest known zoonoses. In recent years, more than 21,000 nucleotide sequences of rabies viruses (RABV), from the prototype species rabies lyssavirus, have been deposited in public databases. Subsequent phylogenetic analyses in combination with metadata suggest geographic distributions of RABV. However, these analyses somewhat experience technical difficulties in defining verifiable criteria for cluster allocations in phylogenetic trees inviting for a more rational approach. Therefore, we applied a relatively new mathematical clustering algorythm named ‘affinity propagation clustering’ (AP) to propose a standardized sub-species classification utilizing full-genome RABV sequences. Because AP has the advantage that it is computationally fast and works for any meaningful measure of similarity between data samples, it has previously been applied successfully in bioinformatics, for analysis of microarray and gene expression data, however, cluster analysis of sequences is still in its infancy. Existing (516) and original (46) full genome RABV sequences were used to demonstrate the application of AP for RABV clustering. On a global scale, AP proposed four clusters, i.e. New World cluster, Arctic/Arctic-like, Cosmopolitan, and Asian as previously assigned by phylogenetic studies. By combining AP with established phylogenetic analyses, it is possible to resolve phylogenetic relationships between verifiably determined clusters and sequences. This workflow will be useful in confirming cluster distributions in a uniform transparent manner, not only for RABV, but also for other comparative sequence analyses.
DOI: 10.5281/zenodo.7115116
title: Defining objective clusters for rabies virus sequences using affinity propagation clustering

description: Rabies is caused by lyssaviruses, and is one of the oldest known zoonoses. In recent years, more than 21,000 nucleotide sequences of rabies viruses (RABV), from the prototype species rabies lyssavirus, have been deposited in public databases. Subsequent phylogenetic analyses in combination with metadata suggest geographic distributions of RABV. However, these analyses somewhat experience technical difficulties in defining verifiable criteria for cluster allocations in phylogenetic trees inviting for a more rational approach. Therefore, we applied a relatively new mathematical clustering algorythm named ‘affinity propagation clustering’ (AP) to propose a standardized sub-species classification utilizing full-genome RABV sequences. Because AP has the advantage that it is computationally fast and works for any meaningful measure of similarity between data samples, it has previously been applied successfully in bioinformatics, for analysis of microarray and gene expression data, however, cluster analysis of sequences is still in its infancy. Existing (516) and original (46) full genome RABV sequences were used to demonstrate the application of AP for RABV clustering. On a global scale, AP proposed four clusters, i.e. New World cluster, Arctic/Arctic-like, Cosmopolitan, and Asian as previously assigned by phylogenetic studies. By combining AP with established phylogenetic analyses, it is possible to resolve phylogenetic relationships between verifiably determined clusters and sequences. This workflow will be useful in confirming cluster distributions in a uniform transparent manner, not only for RABV, but also for other comparative sequence analyses.