DOI: 10.5061/dryad.rq560
title: Data from: Impaired hippocampal place cell dynamics in a mouse model of the 22q11.2 deletion

description: Hippocampal place cells represent the cellular substrate of episodic
 memory. Place cell ensembles reorganize to support learning but must also
 maintain stable representations to facilitate memory recall. Despite
 extensive research, the learning-related role of place cell dynamics in
 health and disease remains elusive. Using chronic two-photon Ca2+ imaging
 in hippocampal area CA1 of wild-type and Df(16)A+/− mice, an animal model
 of 22q11.2 deletion syndrome, one of the most common genetic risk factors
 for cognitive dysfunction and schizophrenia, we found that goal-oriented
 learning in wild-type mice was supported by stable spatial maps and robust
 remapping of place fields toward the goal location. Df(16)A+/− mice showed
 a significant learning deficit accompanied by reduced spatial map
 stability and the absence of goal-directed place cell reorganization.
 These results expand our understanding of the hippocampal ensemble
 dynamics supporting cognitive flexibility and demonstrate their importance
 in a model of 22q11.2-associated cognitive dysfunction.
description: Behavior
 dataData recorded during
 mouse in vivo imaging and behavior sessions. Data saved as Python pickle
 files containing a dictionary of arrays of timestamped mouse behavior
 recordings and stimulus presentaitons. Data includes licking activity,
 treadmill position, and contextual stimuli presentation times. Data is
 designed to be read by corresponding figure code at
 https://github.com/losonczylab/Zaremba_NatNeurosci_2017.behavior.zipExperiment metadataExperiment metadata xml files containing a record of experimental parameters and links the locations of imaging and behavior data for a given experiment. Data recorded during mouse in vivo imaging and behavior sessions. Data is designed to be read by corresponding figure code at https://github.com/losonczylab/Zaremba_NatNeurosci_2017.metadata.zipPlace cell enrichment model dataContains place cell data recorded during in vivo calcium imaging sessions of our goal-oriented learning task, as well as enrichment model parameters fit to the data, and saved simulations of the place cell enrichment model. Data is designed to be read by corresponding figure code at https://github.com/losonczylab/Zaremba_NatNeurosci_2017.enrichment_model.zipImaging Data - Part 1Calcium imaging data recorded during head-fixed awake in vivo two-photon imaging experiments. Data is designed to be read by corresponding figure code at https://github.com/losonczylab/Zaremba_NatNeurosci_2017.imaging.zip.001Imaging Data - Part 2Calcium imaging data recorded during head-fixed awake in vivo two-photon imaging experiments. Data is designed to be read by corresponding figure code at https://github.com/losonczylab/Zaremba_NatNeurosci_2017.imaging.zip.002Imaging Data - Part 3Calcium imaging data recorded during head-fixed awake in vivo two-photon imaging experiments. Data is designed to be read by corresponding figure code at https://github.com/losonczylab/Zaremba_NatNeurosci_2017.imaging.zip.003Imaging Data - Part 4Calcium imaging data recorded during head-fixed awake in vivo two-photon imaging experiments. Data is designed to be read by corresponding figure code at https://github.com/losonczylab/Zaremba_NatNeurosci_2017.imaging.zip.004Imaging Data - Part 5Calcium imaging data recorded during head-fixed awake in vivo two-photon imaging experiments. Data is designed to be read by corresponding figure code at https://github.com/losonczylab/Zaremba_NatNeurosci_2017.imaging.zip.005Imaging Data - Part 6Calcium imaging data recorded during head-fixed awake in vivo two-photon imaging experiments. Data is designed to be read by corresponding figure code at https://github.com/losonczylab/Zaremba_NatNeurosci_2017.imaging.zip.006Imaging Data - Part 7Calcium imaging data recorded during head-fixed awake in vivo two-photon imaging experiments. Data is designed to be read by corresponding figure code at https://github.com/losonczylab/Zaremba_NatNeurosci_2017.imaging.zip.007Imaging Data - Part 8Calcium imaging data recorded during head-fixed awake in vivo two-photon imaging experiments. Data is designed to be read by corresponding figure code at https://github.com/losonczylab/Zaremba_NatNeurosci_2017.imaging.zip.008Imaging Data - Part 9Calcium imaging data recorded during head-fixed awake in vivo two-photon imaging experiments. Data is designed to be read by corresponding figure code at https://github.com/losonczylab/Zaremba_NatNeurosci_2017.imaging.zip.009Imaging Data - Part 10Calcium imaging data recorded during head-fixed awake in vivo two-photon imaging experiments. Data is designed to be read by corresponding figure code at https://github.com/losonczylab/Zaremba_NatNeurosci_2017.imaging.zip.010Imaging Data - Part 11Calcium imaging data recorded during head-fixed awake in vivo two-photon imaging experiments. Data is designed to be read by corresponding figure code at https://github.com/losonczylab/Zaremba_NatNeurosci_2017.imaging.zip.011Imaging Data - Part 12Calcium imaging data recorded during head-fixed awake in vivo two-photon imaging experiments. Data is designed to be read by corresponding figure code at https://github.com/losonczylab/Zaremba_NatNeurosci_2017.imaging.zip.012Imaging Data - Part 13Calcium imaging data recorded during head-fixed awake in vivo two-photon imaging experiments. Data is designed to be read by corresponding figure code at https://github.com/losonczylab/Zaremba_NatNeurosci_2017.imaging.zip.013Imaging Data - Part 14Calcium imaging data recorded during head-fixed awake in vivo two-photon imaging experiments. Data is designed to be read by corresponding figure code at https://github.com/losonczylab/Zaremba_NatNeurosci_2017.imaging.zip.014Imaging Data - Part 15Calcium imaging data recorded during head-fixed awake in vivo two-photon imaging experiments. Data is designed to be read by corresponding figure code at https://github.com/losonczylab/Zaremba_NatNeurosci_2017.imaging.zip.015Imaging Data - Part 16Calcium imaging data recorded during head-fixed awake in vivo two-photon imaging experiments. Data is designed to be read by corresponding figure code at https://github.com/losonczylab/Zaremba_NatNeurosci_2017.imaging.zip.016