cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.6272669.v1
title: Effect of melatonin on antioxidant capacity, ınflammation and apoptotic cell death in lung tissue of diabetic rats

description: Abstract Purpose: To investigate the effects of melatonin on antioxidant capacity, inflammation and apoptotic cell death (through expression of cleaved-caspase 3) in lung tissue samples of diabetic rats. Methods: Thirty male Sprague-Dawley rats were randomly divided into three groups. Group 1 (control group) was made up of healthy rats. Group 2 (diabetes group) received streptozotocin at a dose of 50 mg/kg/day for 5 days.Group 3 (diabetes plus melatonin group) received streptozotocin at a dose of 50 mg/kg/day for 5 days and then they received melatonin at a dose of 20 mg/kg/day between 28thand 35thdays of the study. Results: Tissue MDA and MPO levels were found to be significantly higher in diabetes group compared to control group (p&lt;0.05) whilst administration of melatonin was found to significantly lower this increase down to normal levels (p&lt;0.05). Bronchus associated lymphoid tissue (BALT) was more severe in diabetics whereas administration of melatonin alleviated this hyperplasia. Cleaved caspase 3 activity was severe in hyperplastic BALT in diabetic rats however in lowered down to moderate level when melatonin was administered. Conclusion: The melatonin caused an increase in antioxidant capacity and decreased the expression of cleaved-caspase 3.
DOI: 10.6084/m9.figshare.6272666
title: Feasibility studies to use construction waste in the sorption of Pb 2+ , Cd 2+ , Cr 3+ and As 5+

description: ABSTRACT This study evaluated the retention capacity of Pb2+, Cd2+, Cr3+ and As5+ per two types of soil, a clayey Latosoil and a sandy soil, by construction waste and mixtures containing 70% of soil and 30% of construction waste’s particles. For this, batch equilibrium tests were performed with samples of the five sorbents (construction waste, clayey soil, sandy soil, mixtures of clayey soil-construction waste and sandy soil-construction waste) added to monospecie solutions of lead, cadmium and chromium in the form of nitrate; and arsenic in the form of sodium arsenate, allowing the evaluation of how each element interacted with each sample. Five batches of samples were tested, in triplicate, with the same sorbent solution ratio, 1:20, and the concentrations of the solutions varied. Freundlich and Langmuir’s theoretical sorption curves were used to adjust the pairs of data points, the equilibrium concentration of solute in the solution (Ce) versus the solute mass sorbed per soil mass (S). The results allow concluding that the construction waste had greater ability to absorb Pb2+, Cd2+ and Cr3+. As5+, however, is more strongly sorbed by the clayey soil and by the mixture clayey soil-construction waste. The sorptive processes of Pb2+, Cd2+, and Cr3+ differ from the sorptive processes of As5+, because the first ones behave as cations in the soil, while the latter behaves as oxyanion. Finally, the clayey soil showed greater sorption capacity than the sandy soil for all the metals studied, as clayey soil has a higher organic material content.
DOI: 10.6084/m9.figshare.6272666.v1
title: Feasibility studies to use construction waste in the sorption of Pb 2+ , Cd 2+ , Cr 3+ and As 5+

description: ABSTRACT This study evaluated the retention capacity of Pb2+, Cd2+, Cr3+ and As5+ per two types of soil, a clayey Latosoil and a sandy soil, by construction waste and mixtures containing 70% of soil and 30% of construction waste’s particles. For this, batch equilibrium tests were performed with samples of the five sorbents (construction waste, clayey soil, sandy soil, mixtures of clayey soil-construction waste and sandy soil-construction waste) added to monospecie solutions of lead, cadmium and chromium in the form of nitrate; and arsenic in the form of sodium arsenate, allowing the evaluation of how each element interacted with each sample. Five batches of samples were tested, in triplicate, with the same sorbent solution ratio, 1:20, and the concentrations of the solutions varied. Freundlich and Langmuir’s theoretical sorption curves were used to adjust the pairs of data points, the equilibrium concentration of solute in the solution (Ce) versus the solute mass sorbed per soil mass (S). The results allow concluding that the construction waste had greater ability to absorb Pb2+, Cd2+ and Cr3+. As5+, however, is more strongly sorbed by the clayey soil and by the mixture clayey soil-construction waste. The sorptive processes of Pb2+, Cd2+, and Cr3+ differ from the sorptive processes of As5+, because the first ones behave as cations in the soil, while the latter behaves as oxyanion. Finally, the clayey soil showed greater sorption capacity than the sandy soil for all the metals studied, as clayey soil has a higher organic material content.
DOI: 10.6084/m9.figshare.6272663
title: Soil Erodibility under Natural Rainfall Conditions as the K Factor of the Universal Soil Loss Equation and Application of the Nomograph for a Subtropical Ultisol

description: ABSTRACT: Erodibility represents the intrinsic susceptibility of the soil to the erosion process, represented by the K factor in the Universal Soil Loss Equation (USLE). In Brazil, there are few field experiments determined with a series larger than ten years of data, which are the most reliable for quantifying the K factor. The aim of this study was to determine the K factor of the USLE by the direct method, relating soil losses determined in the field under standard conditions to erosivity of rains, and by the analytic method, applying the Wischmeier nomograph. The data on soil loss by water erosion were obtained in a field experiment under natural rainfall conditions from 1976 to 1989 in an Ultisol at the Agronomic Experimental Station in Eldorado do Sul, RS, Brazil. The value of the K factor by the direct method was 0.0338 Mg ha h ha-1 MJ-1 mm-1, which is high, showing considerable susceptibility of the soil to erosion. From the analytical method, the K factor obtained was 0.0325 Mg ha h ha-1 MJ-1 mm-1, a value very close to that determined experimentally. Thus, the Wischmeier nomograph proved to be valid for determination of the K factor of the Ultisol under study. This method proved to be valid for this type of soil. These results can be used for calibration models based on the USLE.
DOI: 10.6084/m9.figshare.6272663.v1
title: Soil Erodibility under Natural Rainfall Conditions as the K Factor of the Universal Soil Loss Equation and Application of the Nomograph for a Subtropical Ultisol

description: ABSTRACT: Erodibility represents the intrinsic susceptibility of the soil to the erosion process, represented by the K factor in the Universal Soil Loss Equation (USLE). In Brazil, there are few field experiments determined with a series larger than ten years of data, which are the most reliable for quantifying the K factor. The aim of this study was to determine the K factor of the USLE by the direct method, relating soil losses determined in the field under standard conditions to erosivity of rains, and by the analytic method, applying the Wischmeier nomograph. The data on soil loss by water erosion were obtained in a field experiment under natural rainfall conditions from 1976 to 1989 in an Ultisol at the Agronomic Experimental Station in Eldorado do Sul, RS, Brazil. The value of the K factor by the direct method was 0.0338 Mg ha h ha-1 MJ-1 mm-1, which is high, showing considerable susceptibility of the soil to erosion. From the analytical method, the K factor obtained was 0.0325 Mg ha h ha-1 MJ-1 mm-1, a value very close to that determined experimentally. Thus, the Wischmeier nomograph proved to be valid for determination of the K factor of the Ultisol under study. This method proved to be valid for this type of soil. These results can be used for calibration models based on the USLE.
DOI: 10.6084/m9.figshare.6272660
title: Action of a deproteinized xenogenic biomaterial in the process of bone repair in rats submitted to inhalation of cigarette smoke

description: Abstract Purpose: To investigate if the inorganic bovine bone matrix changes the bone formation in rats submitted to inhalation of cigarette smoke. Methods: Twenty Wistar rats were divided into two groups: Cigarette Clot Group (CCG), which in the inhalation chamber received the smoke of 10 cigarettes, 3 times a day, 10 minutes, for 30 days and had the surgical cavity filled by clot; Cigarette Biomaterial Group (CBG), submitted to the same inhalation technique but with the cavity filled by biomaterial. Results: In CCG there was a significant difference of new bone tissue in the analyzed periods (15 and 45 days), and in 15 days, there was 4.8 ± 0.42 of bone formed and 11.73 ± 0.59 (p &lt;0.05) in 45 days. The CBG also showed a significant difference between the periods of 15 to 45 days, being respectively 6.16 ± 0.30 and 11.60 ± 0.61. However, when the groups were compared, within the same analyzed periods, a significant difference was observed only in the period of 15 days, with the new bone percentage being greater in the CBG. Conclusion: The bone matrix acted as an osteoinductive biomaterial, biocompatible and aided in the repair process, mainly in the initial period of recovery.
DOI: 10.6084/m9.figshare.6272660.v1
title: Action of a deproteinized xenogenic biomaterial in the process of bone repair in rats submitted to inhalation of cigarette smoke

description: Abstract Purpose: To investigate if the inorganic bovine bone matrix changes the bone formation in rats submitted to inhalation of cigarette smoke. Methods: Twenty Wistar rats were divided into two groups: Cigarette Clot Group (CCG), which in the inhalation chamber received the smoke of 10 cigarettes, 3 times a day, 10 minutes, for 30 days and had the surgical cavity filled by clot; Cigarette Biomaterial Group (CBG), submitted to the same inhalation technique but with the cavity filled by biomaterial. Results: In CCG there was a significant difference of new bone tissue in the analyzed periods (15 and 45 days), and in 15 days, there was 4.8 ± 0.42 of bone formed and 11.73 ± 0.59 (p &lt;0.05) in 45 days. The CBG also showed a significant difference between the periods of 15 to 45 days, being respectively 6.16 ± 0.30 and 11.60 ± 0.61. However, when the groups were compared, within the same analyzed periods, a significant difference was observed only in the period of 15 days, with the new bone percentage being greater in the CBG. Conclusion: The bone matrix acted as an osteoinductive biomaterial, biocompatible and aided in the repair process, mainly in the initial period of recovery.
DOI: 10.6084/m9.figshare.6272657
title: Evaluation of sleep pattern in insomnia in benzodiazepine users and analysis of trazodone as a substitute medication

description: ABSTRACT Objective To know the modifications of the sleep pattern in chronic benzodiazepine users after the introduction of trazodone. Methods In a group of 11 patients, a gradual withdrawal of benzodiazepine (BZD) was introduced with progressive introduction of trazodone. Two polysomnograms were performed, the first with BZD usual dose of the patient and the second after BZD suppression and with 150 mg of prolonged release trazodone. Sleep quality questionnaires (Pittsburgh), daytime sleepiness (Epworth) and depressive (Hamilton) and anxious (Beck) symptoms were applied. Results Five subjects completed the study and were followed up for at least six weeks. In these patients, trazodone significantly increased sleep efficiency and REM sleep and decreased wakefulness after sleep onset. There was an improvement in sleep quality, but there was no change in depressive and anxious symptoms. Conclusion Prolonged release trazodone has been shown to be a therapeutic option for chronic insomnia patients with benzodiazepines with effective withdrawal of the anxiolytic drug. There was improvement in sleep quality by questionnaire and polysomnography. More patients will be needed to determine the benefits of trazodone in this type of intervention.
DOI: 10.6084/m9.figshare.6272657.v1
title: Evaluation of sleep pattern in insomnia in benzodiazepine users and analysis of trazodone as a substitute medication

description: ABSTRACT Objective To know the modifications of the sleep pattern in chronic benzodiazepine users after the introduction of trazodone. Methods In a group of 11 patients, a gradual withdrawal of benzodiazepine (BZD) was introduced with progressive introduction of trazodone. Two polysomnograms were performed, the first with BZD usual dose of the patient and the second after BZD suppression and with 150 mg of prolonged release trazodone. Sleep quality questionnaires (Pittsburgh), daytime sleepiness (Epworth) and depressive (Hamilton) and anxious (Beck) symptoms were applied. Results Five subjects completed the study and were followed up for at least six weeks. In these patients, trazodone significantly increased sleep efficiency and REM sleep and decreased wakefulness after sleep onset. There was an improvement in sleep quality, but there was no change in depressive and anxious symptoms. Conclusion Prolonged release trazodone has been shown to be a therapeutic option for chronic insomnia patients with benzodiazepines with effective withdrawal of the anxiolytic drug. There was improvement in sleep quality by questionnaire and polysomnography. More patients will be needed to determine the benefits of trazodone in this type of intervention.
DOI: 10.6084/m9.figshare.6272648
title: Vascular endothelial growth factor association with angiopoietin 1 promotes improvement in ventricular function after ischemic cardiomyopathy induced in mini pigs

description: Abstract Purpose: To investigate the safety and clinical, hemodynamic and tissue improvement ability in mini pigs undergoing cell and gene therapy for the treatment of acute myocardial infarction. Methods: Thirty-two mini pigs Br1 lineage, 12 months old, undergoing induction of acute myocardial infarction by occlusion of the diagonal branch of the paraconal coronary. They were divided into 4 groups: one control group and 3 treatment groups (cell therapy and gene cell therapy). Echocardiography reviews were performed on three occasions and histopathological analysis was performed after 4 weeks. Analysis of variance (ANOVA), Tukey and Wilcoxon tests, were performed. Results: Association of vascular endothelial growth factor (VEGF) with angiopoietin1 (Ang1) presented satisfactory results in the improvement of ventricular function following ischemic cardiomyopathy in mini pigs when compared to the results of the other treated groups. Conclusion: The therapy with VEGF and the combination of VEGF with Ang1, promoted recovered function of the myocardium, characterized by reduced akinetic area and induction of neovascularization.
DOI: 10.6084/m9.figshare.6272648.v1
title: Vascular endothelial growth factor association with angiopoietin 1 promotes improvement in ventricular function after ischemic cardiomyopathy induced in mini pigs

description: Abstract Purpose: To investigate the safety and clinical, hemodynamic and tissue improvement ability in mini pigs undergoing cell and gene therapy for the treatment of acute myocardial infarction. Methods: Thirty-two mini pigs Br1 lineage, 12 months old, undergoing induction of acute myocardial infarction by occlusion of the diagonal branch of the paraconal coronary. They were divided into 4 groups: one control group and 3 treatment groups (cell therapy and gene cell therapy). Echocardiography reviews were performed on three occasions and histopathological analysis was performed after 4 weeks. Analysis of variance (ANOVA), Tukey and Wilcoxon tests, were performed. Results: Association of vascular endothelial growth factor (VEGF) with angiopoietin1 (Ang1) presented satisfactory results in the improvement of ventricular function following ischemic cardiomyopathy in mini pigs when compared to the results of the other treated groups. Conclusion: The therapy with VEGF and the combination of VEGF with Ang1, promoted recovered function of the myocardium, characterized by reduced akinetic area and induction of neovascularization.
DOI: 10.6084/m9.figshare.6272639
title: Does high intensity exercise affects irisin plasma levels in hemodialysis patients? A pilot study

description: ABSTRACT Background: Irisin is a recently identified exercise-induced hormone that stimulates the "browning" of the white adipose tissue, at least in mice. In chronic kidney disease (CKD) patients, irisin regulation is not fully understood, and little attention has been given to the effects of exercise on irisin levels in these patients. The purpose of this study was to assess the effects of high intensity exercise on irisin plasma levels in CKD patients under hemodialysis (HD). Methods: Fifteen HD patients (5 men, 44.4 ± 15.1 years old) were studied and served as their own controls. High intensity (single session) intradialytic strength exercises consisted of three sets of ten repetitions with four different movements in both lower limbs during 30 minutes. Blood samples were collected on different days (exercise and non-exercise day) at exactly the same time (30 and 60 minutes after the start of dialysis session). Plasma irisin levels were measured by ELISA assay and anthropometric and biochemical parameters were evaluated. Results: Irisin plasma levels were significantly reduced in both exercise day (125.0 ± 18.5 to 117.4 ± 15.0 ng/mL, p=0.02) and non-exercise day (121.5 ± 13.7 to 115.4 ± 17.2 ng/mL, p=0.02) after 60 minutes of dialysis. Conclusion: These data suggest that intense intradialytic strength exercise was unable to increase the circulating concentration of irisin in HD patients. Moreover, our data show that after one hour of dialysis session, irisin plasma levels may be reduced.
DOI: 10.6084/m9.figshare.6272639.v1
title: Does high intensity exercise affects irisin plasma levels in hemodialysis patients? A pilot study

description: ABSTRACT Background: Irisin is a recently identified exercise-induced hormone that stimulates the "browning" of the white adipose tissue, at least in mice. In chronic kidney disease (CKD) patients, irisin regulation is not fully understood, and little attention has been given to the effects of exercise on irisin levels in these patients. The purpose of this study was to assess the effects of high intensity exercise on irisin plasma levels in CKD patients under hemodialysis (HD). Methods: Fifteen HD patients (5 men, 44.4 ± 15.1 years old) were studied and served as their own controls. High intensity (single session) intradialytic strength exercises consisted of three sets of ten repetitions with four different movements in both lower limbs during 30 minutes. Blood samples were collected on different days (exercise and non-exercise day) at exactly the same time (30 and 60 minutes after the start of dialysis session). Plasma irisin levels were measured by ELISA assay and anthropometric and biochemical parameters were evaluated. Results: Irisin plasma levels were significantly reduced in both exercise day (125.0 ± 18.5 to 117.4 ± 15.0 ng/mL, p=0.02) and non-exercise day (121.5 ± 13.7 to 115.4 ± 17.2 ng/mL, p=0.02) after 60 minutes of dialysis. Conclusion: These data suggest that intense intradialytic strength exercise was unable to increase the circulating concentration of irisin in HD patients. Moreover, our data show that after one hour of dialysis session, irisin plasma levels may be reduced.
DOI: 10.6084/m9.figshare.6272633
title: Luiz Gama. A vida como prova inconcussa da história

description: Abstract The life of Luiz Gama has been appropriated, interpreted and fictionalized. The convergence, superposition and overlapping versions of Luiz Gama, the historical subject, inserted in the Second Reign, and a fictional Gama have given rise to fiery disagreements among his critics and commentators. In the letter written to his friend Lúcio de Mendonça, a memorial and autobiographical outline, Luiz Gama sums up his origin and background. Based on this letter, Lúcio de Mendonça rewrote Gama’s biography and published it in two identical versions. One as a biographical draft in the Almanach literário de São Paulo para o ano de 1881 and another, titled "Folhetim," in the Gazeta da Tarde. We resort to the ideas presented by Rancière (2014), primarily regarding the homonymy of ‘História/história’ (History/story), to make a critical reading of that publication and the reception of Luiz Gama’s letter.
DOI: 10.6084/m9.figshare.6272633.v1
title: Luiz Gama. A vida como prova inconcussa da história

description: Abstract The life of Luiz Gama has been appropriated, interpreted and fictionalized. The convergence, superposition and overlapping versions of Luiz Gama, the historical subject, inserted in the Second Reign, and a fictional Gama have given rise to fiery disagreements among his critics and commentators. In the letter written to his friend Lúcio de Mendonça, a memorial and autobiographical outline, Luiz Gama sums up his origin and background. Based on this letter, Lúcio de Mendonça rewrote Gama’s biography and published it in two identical versions. One as a biographical draft in the Almanach literário de São Paulo para o ano de 1881 and another, titled "Folhetim," in the Gazeta da Tarde. We resort to the ideas presented by Rancière (2014), primarily regarding the homonymy of ‘História/história’ (History/story), to make a critical reading of that publication and the reception of Luiz Gama’s letter.
DOI: 10.6084/m9.figshare.6272618
title: Evaluation of Welding Parameter's Effects on Corrosion Behavior of Bronze-Carbon Steel Dual-Layer Explosion Welded Joint at Salt Enviroment

description: In the current investigation, corrosion behavior and microstructural variations of explosion-welded joint of bronze-carbon steel dual-layer plates were studied. The resultant curves of potentiodynamic's polarization tests demonstrated that the lowest corrosion rate was related to the sample with maximum explosive load thickness, and the highest corrosion speed was for the sample with minimum standoff distance. EIS test results of welded samples were indicative of creating a passive layer at the beginning of immersion process which showed that the polarization resistance has been reduced by increasing of explosive load thickness. So, the corrosion mechanism included two stages; at the beginning of immersion, for the samples with the lower thickness of explosive load, a passive layer would be created around the component due to higher concentration gradient and then, by removing of this layer, the galvanic couple determines the corrosion rate.
DOI: 10.6084/m9.figshare.6272618.v1
title: Evaluation of Welding Parameter's Effects on Corrosion Behavior of Bronze-Carbon Steel Dual-Layer Explosion Welded Joint at Salt Enviroment

description: In the current investigation, corrosion behavior and microstructural variations of explosion-welded joint of bronze-carbon steel dual-layer plates were studied. The resultant curves of potentiodynamic's polarization tests demonstrated that the lowest corrosion rate was related to the sample with maximum explosive load thickness, and the highest corrosion speed was for the sample with minimum standoff distance. EIS test results of welded samples were indicative of creating a passive layer at the beginning of immersion process which showed that the polarization resistance has been reduced by increasing of explosive load thickness. So, the corrosion mechanism included two stages; at the beginning of immersion, for the samples with the lower thickness of explosive load, a passive layer would be created around the component due to higher concentration gradient and then, by removing of this layer, the galvanic couple determines the corrosion rate.