cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.11804394
title: Evaluation of Polymorphisms in IL8 and IL16 Genes in Patients with Acute Coronary Syndrome

description: Abstract Background: Acute coronary syndrome (ACS) is a cardiovascular disease caused by obstruction of coronary arteries by atheromatous plaque. Susceptibility to this disease may be related to genetic variations, such as single nucleotide polymorphisms (SNPs). Objective: In this study, we evaluated the relationship between SNPs in IL8 (rs4073; -251 A/T) and IL16 (rs11556218; T/G) genes and SCA in a Brazilian population. Materials and Methods: A sample of 200 patients with ACS and 50 non-ACS patients hospitalized at the Real Hospital Português, Recife - PE, Brazil, and 220 blood donors (donors) was used. Genotyping was carried out by polymerase chain reaction, and DNA sequencing. Statistical analyzes were performed using the Williams G, Chi-square and Kruskal Wallis tests, using the BioEstat 5.0 program, and the data with a value of p &lt; 0.05 were considered significant. Results: In the IL8 gene, the AT genotype was the most frequent (p &gt; 0.05) in all three groups. In the IL16 gene, genotypic distributions were different between patients with ACS and the donor group (p = 0.002), with the most frequent G allele in the second group (p = 0.0052). The IL-16 cytokine was higher in donors than in patients with ACS (p = 0.04) and the G (TG + GG) allele had higher values of this cytokine (p = 0.01). Conclusions: The results demonstrate the important role of the rs11556218 SNP in IL16 gene in SCA, evidencing that the G allele may be associated with a decreased risk of the disease.
DOI: 10.6084/m9.figshare.11804397.v1
title: Foam mat drying of banana juice: varieties of ripe banana analysis and egg albumen foam

description: Abstract Drying technologies for ripen bananas is needed. Ripe bananas contains more antioxidant levels, anti-cancerous properties, easier to digest and useful for anxiety and depression. Considering nutrition compositional changes and the effect of external factors during processing ripe banana as a flour, foam mat drying with egg albumen foam was chosen. This research aim to provide an overview of banana juice foam mats from three different varieties bananas at level 5 up to 7 of maturity and mixed into different proportion using egg albumen as foaming agent and dried at temperatures from 60 °C to 80 °C in a cabinet dryer to a brittle and porous solid which able to grind. The study revealed that there is a significant difference in combination of banana varieties to rendement, the solubility of the powder and moisture content. The combination of various varieties of bananas is considered better to produce quality of ripen banana flour.
DOI: 10.6084/m9.figshare.11804388
title: Manual and semiautomatic segmentation of bone sarcomas on MRI have high similarity

description: The aims of this study were to evaluate the intra- and interobserver reproducibility of manual segmentation of bone sarcomas in magnetic resonance imaging (MRI) studies and to compare manual and semiautomatic segmentation methods. This retrospective study included twelve osteosarcoma and eight Ewing sarcoma MRI studies performed prior to any therapeutic intervention. All cases were histopathologically confirmed. Three radiologists used 3D-Slicer software to perform manual segmentation of bone sarcomas in a blinded and independent manner. One radiologist segmented manually and also performed semiautomatic segmentation with the GrowCut tool. Segmentation exercises were timed for comparison. The dice similarity coefficient (DSC) and Hausdorff distance (HD) were used to evaluate similarity between the segmentation results and further statistical analyses were performed to compare DSC, HD, and volumetric results. Manual segmentation was reproducible with intraobserver DSC varying from 0.83 to 0.97 and HD from 3.37 to 28.73 mm. Interobserver DSC of manual segmentation showed variation from 0.73 to 0.97 and HD from 3.93 to 33.40 mm. Semiautomatic segmentation compared to manual segmentation resulted in DSCs of 0.71−0.96 and HDs of 5.38−31.54 mm. Semiautomatic segmentation required significantly less time compared to manual segmentation (P value ≤0.05). Among all situations compared, tumor volumetry did not show significant statistical differences (P value &gt;0.05). We found excellent intra- and interobserver agreement for manual segmentation of osteosarcoma and Ewing sarcoma. There was high similarity between manual and semiautomatic segmentation, with a significant reduction of segmentation time using the semiautomatic method.
DOI: 10.6084/m9.figshare.11804388.v1
title: Manual and semiautomatic segmentation of bone sarcomas on MRI have high similarity

description: The aims of this study were to evaluate the intra- and interobserver reproducibility of manual segmentation of bone sarcomas in magnetic resonance imaging (MRI) studies and to compare manual and semiautomatic segmentation methods. This retrospective study included twelve osteosarcoma and eight Ewing sarcoma MRI studies performed prior to any therapeutic intervention. All cases were histopathologically confirmed. Three radiologists used 3D-Slicer software to perform manual segmentation of bone sarcomas in a blinded and independent manner. One radiologist segmented manually and also performed semiautomatic segmentation with the GrowCut tool. Segmentation exercises were timed for comparison. The dice similarity coefficient (DSC) and Hausdorff distance (HD) were used to evaluate similarity between the segmentation results and further statistical analyses were performed to compare DSC, HD, and volumetric results. Manual segmentation was reproducible with intraobserver DSC varying from 0.83 to 0.97 and HD from 3.37 to 28.73 mm. Interobserver DSC of manual segmentation showed variation from 0.73 to 0.97 and HD from 3.93 to 33.40 mm. Semiautomatic segmentation compared to manual segmentation resulted in DSCs of 0.71−0.96 and HDs of 5.38−31.54 mm. Semiautomatic segmentation required significantly less time compared to manual segmentation (P value ≤0.05). Among all situations compared, tumor volumetry did not show significant statistical differences (P value &gt;0.05). We found excellent intra- and interobserver agreement for manual segmentation of osteosarcoma and Ewing sarcoma. There was high similarity between manual and semiautomatic segmentation, with a significant reduction of segmentation time using the semiautomatic method.
DOI: 10.6084/m9.figshare.11804394.v1
title: Evaluation of Polymorphisms in IL8 and IL16 Genes in Patients with Acute Coronary Syndrome

description: Abstract Background: Acute coronary syndrome (ACS) is a cardiovascular disease caused by obstruction of coronary arteries by atheromatous plaque. Susceptibility to this disease may be related to genetic variations, such as single nucleotide polymorphisms (SNPs). Objective: In this study, we evaluated the relationship between SNPs in IL8 (rs4073; -251 A/T) and IL16 (rs11556218; T/G) genes and SCA in a Brazilian population. Materials and Methods: A sample of 200 patients with ACS and 50 non-ACS patients hospitalized at the Real Hospital Português, Recife - PE, Brazil, and 220 blood donors (donors) was used. Genotyping was carried out by polymerase chain reaction, and DNA sequencing. Statistical analyzes were performed using the Williams G, Chi-square and Kruskal Wallis tests, using the BioEstat 5.0 program, and the data with a value of p &lt; 0.05 were considered significant. Results: In the IL8 gene, the AT genotype was the most frequent (p &gt; 0.05) in all three groups. In the IL16 gene, genotypic distributions were different between patients with ACS and the donor group (p = 0.002), with the most frequent G allele in the second group (p = 0.0052). The IL-16 cytokine was higher in donors than in patients with ACS (p = 0.04) and the G (TG + GG) allele had higher values of this cytokine (p = 0.01). Conclusions: The results demonstrate the important role of the rs11556218 SNP in IL16 gene in SCA, evidencing that the G allele may be associated with a decreased risk of the disease.
DOI: 10.6084/m9.figshare.11804379
title: Influence of Media Geometry on Wet Grinding of a Planetary Ball Mill

description: Planetary ball mills are able to perform dry and wet grinding. Most experimental analyses and computer simulations in this field are mainly about dry grinding. In order to empirically evaluate the wet grinding process, test grindings benches were manufactured, calcined alumina powder was ground, and the particle distribution analyzed. Effects of the media geometry (size and shape) on particle distribution, morphology, and phase composition of ground alumina were investigated. Smaller media leads to smaller particle size and cylindrical media provides a poor grinding performance but its product has the narrower particle size distribution. Alumina showed no phase change in the grinding tests. The experiments presented in this study can be used as an aid in the proper choice of grinding media or even to validate emerging models capable of predicting breakage in wet grinding.
DOI: 10.6084/m9.figshare.11804385
title: Case Report: Myocardial Bypass in Left Descending Artery - A Rare Congenital Anomaly

description: Abstract Myocardial bypass (MB) is known to have scientific relevance and is present in several studies with great statistical significance regarding its clinical manifestations and complications. There are still questions about MB in its relationship with heart disease and repercussion in life-threatening conditions. We present a case report of a MB in the left anterior descending coronary artery, whose objective is to identify this rare congenital anomaly and to highlight the patient's clinical outcome in order to elicit greater contributions about the presence of this variant in the emergency room, its diagnosis by angiography and therapeutic management.
DOI: 10.6084/m9.figshare.11804379.v1
title: Influence of Media Geometry on Wet Grinding of a Planetary Ball Mill

description: Planetary ball mills are able to perform dry and wet grinding. Most experimental analyses and computer simulations in this field are mainly about dry grinding. In order to empirically evaluate the wet grinding process, test grindings benches were manufactured, calcined alumina powder was ground, and the particle distribution analyzed. Effects of the media geometry (size and shape) on particle distribution, morphology, and phase composition of ground alumina were investigated. Smaller media leads to smaller particle size and cylindrical media provides a poor grinding performance but its product has the narrower particle size distribution. Alumina showed no phase change in the grinding tests. The experiments presented in this study can be used as an aid in the proper choice of grinding media or even to validate emerging models capable of predicting breakage in wet grinding.
DOI: 10.6084/m9.figshare.11804373
title: Model of association of springs in parallel in activities of teaching of Physics: an analysis of the domain of validity

description: Abstract Spring associations are often explored in Physics teaching through a theoretical model that defines the equivalent elastic constant of a set of springs in parallel as the sum of the spring constants of each of the associated springs. Like any scientific model, this representation is constructed by assuming a series of idealizations that delimit its validity domain. In the mentioned model, it is assumed that, when a force is applied, the associated springs extend equally, that is, they present a same deformation. For the case where two springs are used to sustain an object vertically, we will hardly have this condition respected In this paper, we present a discussion about the association of two springs in parallel from the perspective of the Bunge modeling process. We propose an expansion of the traditionally explored theoretical model considering the association of two parallel springs that do not deform equally. We also present an empirical comparison of the traditional model and the proposed expanded model. We understand that the discussion built has the potential to, besides providing the mobilization of basic physics knowledge, foster discussions about the representational role of scientific knowledge, enabling situations that demand reflection on the nature of Science.
DOI: 10.6084/m9.figshare.11804376
title: Effect of Testosterone on Proliferation Markers and Apoptosis in Breasts of Ovariectomized Rats

description: Abstract Objective To investigate the action of testosterone (T), isolated or associated with estradiol benzoate (EB), on the proliferation markers and apoptosis of breasts of ovariectomized rats. Methods A total of 48 castrated female Wistar rats were divided into 6 groups, and each of them were submitted to one of the following treatments for 5 weeks: 1) control; 2) EB 50 mcg/day + T 50 mcg/day; 3) T 50mcg/day; 4) EB 50 mcg +T 300 mcg/day; 5) T 300 mcg/day; and 6) EB 50 mcg/day. After the treatment, the mammary tissue was submitted to a histological analysis and immunoexpression evaluation of proliferation markers (proliferating cell nuclear antigen, PCNA) and apoptosis (caspase-3). Results There was a statistically significant difference among the groups regarding microcalcifications and secretory activity, with higher prevalence in the groups treated with EB. There was no difference among the groups regarding atrophy, but a higher prevalence of atrophy was found in the groups that received T versus those that received EB +T. There was a difference among the groups regarding the PCNA (p = 0.028), with higher expression in the group submitted to EB +T 300 mcg/day. Regarding caspase-3, there was no difference among the groups; however, in the group submitted to EB +T 300 mcg/day, the expression was higher than in the isolated T group. Conclusion Isolated T did not have a proliferative effect on the mammary tissue, contrary to EB. Testosterone in combination with EB may or may not decrease the proliferation, depending on the dose of T.
DOI: 10.6084/m9.figshare.11804385.v1
title: Case Report: Myocardial Bypass in Left Descending Artery - A Rare Congenital Anomaly

description: Abstract Myocardial bypass (MB) is known to have scientific relevance and is present in several studies with great statistical significance regarding its clinical manifestations and complications. There are still questions about MB in its relationship with heart disease and repercussion in life-threatening conditions. We present a case report of a MB in the left anterior descending coronary artery, whose objective is to identify this rare congenital anomaly and to highlight the patient's clinical outcome in order to elicit greater contributions about the presence of this variant in the emergency room, its diagnosis by angiography and therapeutic management.
DOI: 10.6084/m9.figshare.11804370
title: A genetic variant in microRNA-146a is associated with sporadic breast cancer in a Southern Brazilian Population

description: Abstract MicroRNAs (miRNAs) play an essential role in gene expression and affect the development of tumours, including breast cancer (BC). Polymorphisms in miRNA genes can affect the interaction of miRNAs with their target messenger RNA by interfering, creating or disrupting target sites. The single nucleotide polymorphism (SNP) rs2910164, located in the seed region of miR146a, was shown to be associated with BC among different populations. In the present study, we investigated whether rs2910164 is associated with BC in 326 patients and 411 controls from a Brazilian population of predominantly European ancestry. The presence of the allele rs2910164*C was associated with an increased risk of BC (OR=1.4, 95% CI=1.03-1.85, p = 0.03). We also analysed publicly available RNA-seq data to evaluate if miR146a is differentially expressed in different subtypes of BC. Genotyping was performed by polymerase chain reaction with sequence-specific primers (PCR-SSP). By leveraging public data from TCGA database, we analysed 461 patients and found that miR146a is significantly more expressed in BC than in non-tumor tissue (1.47 fold, p = 0.02) and is expressed to a greater degree in aggressive BC subtypes.
DOI: 10.6084/m9.figshare.11804376.v1
title: Effect of Testosterone on Proliferation Markers and Apoptosis in Breasts of Ovariectomized Rats

description: Abstract Objective To investigate the action of testosterone (T), isolated or associated with estradiol benzoate (EB), on the proliferation markers and apoptosis of breasts of ovariectomized rats. Methods A total of 48 castrated female Wistar rats were divided into 6 groups, and each of them were submitted to one of the following treatments for 5 weeks: 1) control; 2) EB 50 mcg/day + T 50 mcg/day; 3) T 50mcg/day; 4) EB 50 mcg +T 300 mcg/day; 5) T 300 mcg/day; and 6) EB 50 mcg/day. After the treatment, the mammary tissue was submitted to a histological analysis and immunoexpression evaluation of proliferation markers (proliferating cell nuclear antigen, PCNA) and apoptosis (caspase-3). Results There was a statistically significant difference among the groups regarding microcalcifications and secretory activity, with higher prevalence in the groups treated with EB. There was no difference among the groups regarding atrophy, but a higher prevalence of atrophy was found in the groups that received T versus those that received EB +T. There was a difference among the groups regarding the PCNA (p = 0.028), with higher expression in the group submitted to EB +T 300 mcg/day. Regarding caspase-3, there was no difference among the groups; however, in the group submitted to EB +T 300 mcg/day, the expression was higher than in the isolated T group. Conclusion Isolated T did not have a proliferative effect on the mammary tissue, contrary to EB. Testosterone in combination with EB may or may not decrease the proliferation, depending on the dose of T.
DOI: 10.6084/m9.figshare.11804367
title: Ores and Other items of Natural History: Symbols of the Frontier in the Collection and Foundation of the State Museum of Goiás in the 1940s

description: Abstract This article aims to discuss the foundation of the State Museum of Goiás and its relationship with the dissemination of the idea of the frontier of Central Brazil as a region of economic potential with natural resources to be exploited. The research is based on a diverse set of archival and bibliographic sources that describe and contextualize the museological exhibitions and objects in the context of the March to the West, and the relationship of cultural events with other institutions and the discourses of the occupation of the frontier. The archival sources highlight the role played by the first director of the Museum, Zoroastro Artiaga, and his political maneuverings to have the Institution selected as a vehicle for the dissemination of Geosciences and, especially, as a place to promote the natural resources of Goiás. The research also demonstrates that the museological intentions of constructing a collection of objects about the natural history of the Cerrado was more to advance the idea of the frontier of Central Brazil than to collect elements for the exhibition or for scientific research about Goiás’ natural resources.
DOI: 10.6084/m9.figshare.11804370.v1
title: A genetic variant in microRNA-146a is associated with sporadic breast cancer in a Southern Brazilian Population

description: Abstract MicroRNAs (miRNAs) play an essential role in gene expression and affect the development of tumours, including breast cancer (BC). Polymorphisms in miRNA genes can affect the interaction of miRNAs with their target messenger RNA by interfering, creating or disrupting target sites. The single nucleotide polymorphism (SNP) rs2910164, located in the seed region of miR146a, was shown to be associated with BC among different populations. In the present study, we investigated whether rs2910164 is associated with BC in 326 patients and 411 controls from a Brazilian population of predominantly European ancestry. The presence of the allele rs2910164*C was associated with an increased risk of BC (OR=1.4, 95% CI=1.03-1.85, p = 0.03). We also analysed publicly available RNA-seq data to evaluate if miR146a is differentially expressed in different subtypes of BC. Genotyping was performed by polymerase chain reaction with sequence-specific primers (PCR-SSP). By leveraging public data from TCGA database, we analysed 461 patients and found that miR146a is significantly more expressed in BC than in non-tumor tissue (1.47 fold, p = 0.02) and is expressed to a greater degree in aggressive BC subtypes.
DOI: 10.6084/m9.figshare.11804373.v1
title: Model of association of springs in parallel in activities of teaching of Physics: an analysis of the domain of validity

description: Abstract Spring associations are often explored in Physics teaching through a theoretical model that defines the equivalent elastic constant of a set of springs in parallel as the sum of the spring constants of each of the associated springs. Like any scientific model, this representation is constructed by assuming a series of idealizations that delimit its validity domain. In the mentioned model, it is assumed that, when a force is applied, the associated springs extend equally, that is, they present a same deformation. For the case where two springs are used to sustain an object vertically, we will hardly have this condition respected In this paper, we present a discussion about the association of two springs in parallel from the perspective of the Bunge modeling process. We propose an expansion of the traditionally explored theoretical model considering the association of two parallel springs that do not deform equally. We also present an empirical comparison of the traditional model and the proposed expanded model. We understand that the discussion built has the potential to, besides providing the mobilization of basic physics knowledge, foster discussions about the representational role of scientific knowledge, enabling situations that demand reflection on the nature of Science.
DOI: 10.6084/m9.figshare.11804367.v1
title: Ores and Other items of Natural History: Symbols of the Frontier in the Collection and Foundation of the State Museum of Goiás in the 1940s

description: Abstract This article aims to discuss the foundation of the State Museum of Goiás and its relationship with the dissemination of the idea of the frontier of Central Brazil as a region of economic potential with natural resources to be exploited. The research is based on a diverse set of archival and bibliographic sources that describe and contextualize the museological exhibitions and objects in the context of the March to the West, and the relationship of cultural events with other institutions and the discourses of the occupation of the frontier. The archival sources highlight the role played by the first director of the Museum, Zoroastro Artiaga, and his political maneuverings to have the Institution selected as a vehicle for the dissemination of Geosciences and, especially, as a place to promote the natural resources of Goiás. The research also demonstrates that the museological intentions of constructing a collection of objects about the natural history of the Cerrado was more to advance the idea of the frontier of Central Brazil than to collect elements for the exhibition or for scientific research about Goiás’ natural resources.