cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.7813868
title: Source Data Figure 1 .xlsx

description: <b>e</b>, Cell viability of human osteoarthritis (OA) chondrocytes assessed using the alamar blue assay at 1 d, 3 d, 5 d, and 7 d after BNTA treatment (n = 14 for each group; 1 d, nonparametric test; 3 d, 5 d, and 7 d, one-way ANOVA). <b>f</b>, Quantification of mRNA levels for collagen type II alpha 1 chain (<i>COL2A1</i>), aggrecan<i> </i>(<i>ACAN</i>), proteoglycan 4 (<i>PRG4</i>), and SRY-box 9 (<i>SOX9</i>) in human OA chondrocytes treated with BNTA for 6 h. Fold changes relative to vehicle control are shown (n = 6 for each group; <i>COL2A1</i>, <i>ACAN</i>, <i>SOX9</i>, one-way ANOVA; <i>PRG4</i>, nonparametric test; three independent experiments). <b>g</b>, The mRNA levels of <i>Col2a1</i>, <i>Acan</i>, <i>Prg4</i>, and <i>Sox9</i> in interleukin 1 beta ( IL1β, 10 ng ml<sup>-1</sup>)-induced rat OA chondrocytes treated with BNTA for 6 h (n = 6 for each group; <i>Col2a1</i>, one-way ANOVA; <i>Acan</i>, <i>Prg4</i>, and <i>Sox9</i>, nonparametric test; three independent experiments).<b> h,</b> The proteins levels of SOX9 and glyceraldehyde-3-phosphate dehydrogenase (GAPDH) in human OA chondrocytes treated with vehicle or BNTA (0.1 μM) for 2d. <b>i,</b> The proteins levels of COL2A1, SOX9, and GAPDH were detected using western blotting assay in IL1β (10 ng ml<sup>-1</sup>)-induced rat OA chondrocytes treated with or without BNTA (0.1 μM) for 2d. All data are shown as the mean ± standard deviation (s. d.). *<i>P</i> &lt; 0.05, **<i>P</i> &lt; 0.01, ***<i>P</i> &lt; 0.001.
DOI: 10.6084/m9.figshare.7813844
title: Source Data Suppletary Figure 3 .xlsx

description: <b>b</b>, Concentrations of serum Na<sup>+</sup>, K<sup>+</sup>, and urea of rats treated with BNTA or vehicle evaluated by biochemical assays at 4 w (vehicle, 0.015, 0.15 mg kg<sup>-1</sup>, n = 5; 1.5 mg kg<sup>-1</sup>, n = 6; one-way ANOVA). <b>c</b>, Concentrations of serum Na<sup>+</sup>, K<sup>+</sup>, and urea of rats in BNTA or vehicle groups at 8 w (n = 6 for each group; one-way ANOVA). Data are shown as the mean ± standard deviation (s. d.).
DOI: 10.6084/m9.figshare.7813865.v1
title: Source Data Suppletary Figure 5 .xlsx

description: The fluorescence intensity of superoxide dismutase 3 (SOD3) and type II collagen (COLII) in rat primary chondrocytes was quantified using LAS_X software when cultured with interleukin 1 beta ( IL1β, 10 ng ml<sup>-1</sup>), BNTA (0.1 μM), or siSOD3 for 2 d (n = 25 for each group; nonparametric tests). Data are shown as the mean ± standard deviation (s. d.). ***<i>P</i> &lt; 0.001.
DOI: 10.6084/m9.figshare.7813835
title: Source Data Suppletary Figure 4.xlsx

description: <b> c</b>, <i>Sod3</i> mRNA levels in cartilage tissue of the rat osteoarthritis (OA) model at 8 w (nonparametric test; n = 5 for each group). <b>g</b>, <i>Sod3 </i>mRNA levels in rat primary chondrocytes after treatment with three siSOD3s at 24 h (one-way ANOVA; n = 5 for each group). Data are shown as the mean ± standard deviation (s. d.). *<i>P</i> &lt; 0.05, **<i>P</i> &lt; 0.01.
DOI: 10.6084/m9.figshare.7813835.v1
title: Source Data Suppletary Figure 4.xlsx

description: <b> c</b>, <i>Sod3</i> mRNA levels in cartilage tissue of the rat osteoarthritis (OA) model at 8 w (nonparametric test; n = 5 for each group). <b>g</b>, <i>Sod3 </i>mRNA levels in rat primary chondrocytes after treatment with three siSOD3s at 24 h (one-way ANOVA; n = 5 for each group). Data are shown as the mean ± standard deviation (s. d.). *<i>P</i> &lt; 0.05, **<i>P</i> &lt; 0.01.
DOI: 10.6084/m9.figshare.7813844.v1
title: Source Data Suppletary Figure 3 .xlsx

description: <b>b</b>, Concentrations of serum Na<sup>+</sup>, K<sup>+</sup>, and urea of rats treated with BNTA or vehicle evaluated by biochemical assays at 4 w (vehicle, 0.015, 0.15 mg kg<sup>-1</sup>, n = 5; 1.5 mg kg<sup>-1</sup>, n = 6; one-way ANOVA). <b>c</b>, Concentrations of serum Na<sup>+</sup>, K<sup>+</sup>, and urea of rats in BNTA or vehicle groups at 8 w (n = 6 for each group; one-way ANOVA). Data are shown as the mean ± standard deviation (s. d.).
DOI: 10.6084/m9.figshare.7813808
title: Source Data Suppletary Figure 2 .xlsx

description: Cell viability of rat primary chondrocytes detected using the alamar blue assay after BNTA treatment for 1 d, 3 d, 5 d, and 7 d (n = 14 for each group; 1 d and 3 d, one-way ANOVA; 5 d and 7 d, nonparametric test). Data are shown as the mean ± standard deviation (s. d.). *<i>P</i> &lt; 0.05, **<i>P</i> &lt; 0.01.
DOI: 10.6084/m9.figshare.7813799
title: Source Data Suppletary Figure 1 .xlsx

description: The collagen type II alpha 1 chain (<i>Col2a1</i>)<i>,</i> aggrecan (<i>Acan</i>)<i>,</i> and SRY-box 9 (<i>Sox9</i>) mRNA levels were evaluated after BNTA (0.1 μM) treatment compared with glucosamine sulfate (GS, 500 μM) in interleukin 1 beta (IL1β, 10 ng ml<sup>-1</sup>)-induced rat osteoarthritis (OA) model at 6 h (n = 5 for each group; <i>Col2a1,</i> <i>Acan,</i> one-way ANOVA; <i>Sox9, </i>nonparametric test). Data are shown as the mean ± standard deviation (s. d.). *<i>P</i> &lt; 0.05, **<i>P</i> &lt; 0.01, ***<i>P</i> &lt; 0.001.
DOI: 10.6084/m9.figshare.7813802
title: Plotting a future for Amazonian canga vegetation in a campo rupestre context - Supplementary data

description: These are the supplementary data for our study on biogeography and conservation of the flora of <i>campo rupestre</i> vegetation in Brazil. We compared the differences in plant species composition and lineage distribution of <i>campos rupestres</i> in the Amazonian Carajás (Pará state) and easter Brazil (Minas Gerais and Bahia states). The study is published in the journal Plos One. <br><br><br>The supplementary data is described as follow:<br><b>S1 Fig</b> shows the flow chart of methods used in our analyses. Red symbols represent the sites with canga substrate (inedited database produced for this paper). Blue symbols represent sites with quartzite substrate and lilac symbol sites with mixed substrate (both canga and quartzite), produced for Zappi et al (2017) paper (https://doi.org/10.3389/fpls.2017.02141).<br><b>S2 Fig</b> shows the SOS values for our sites. SOS values express clades with differential over-representation of certain lineages in a set of sites, versus lineages with over-representation elsewhere (see Borregaard et al. 2014). This analysis was made with '<i>nodiv</i>' R package (https://doi.org/10.1111/2041-210X.12283).<br><br><b>S3 Fig </b>is the graph with the results of the rarefaction, extrapolation and Angiosperm species richness estimation of <i>campo rupestre </i>in Carajás. These analyses were made on software EstimateS (https://doi.org/10.1111/ecog.00814)<br><b>S4 Fig</b> brings the phylogenetic tree of all species from the campos rupestres in both Carajás and Espinhaço range in PDF format. This tree was generate in iTol (https://itol.embl.de) using the <b>S2 Text</b> file available here.<br><br><b>S1 Text</b> is the script used for all analyses done in R environment (note that some analyses were made in different software like Phylocom and EstimateS, as described in the paper).<br><b>S2 Text</b> is the dated phylogenetic tree showing evolutive relationships between all species present in our database. This tree was created in the software Phylocom based on the megatree 'R20160415.new', which is provided by Gastauer and Meira-Neto (2017) in their datapaper (https://doi.org/10.1590/0102-33062016abb0306).<br><b>S1 Table</b> contains the data matrix showing the presence of plant species in each of the 14 individual sites on mountaintops in Carajás (Pará state), which was used in the multivariate analysis, rarefaction and richness estimation for the area.<br><br><b>S2 Table</b> contains the data matrix showing the presence of plant species for each of the 14 Carajás sites plus the 14 sites of <i>campo rupestre</i> of easter Brazil (Minas Gerais and Bahia states - see Zappi et al. 2017 paper), which was used in the biogeographical comparison at national level.<br><b>S3 Table </b>brings the raw results of the rarefaction, extrapolation and species richness estimation of campo rupestre in Carajás. These analyses were made on software EstimateS (https://doi.org/10.1111/ecog.00814).<br>
DOI: 10.6084/m9.figshare.7813808.v1
title: Source Data Suppletary Figure 2 .xlsx

description: Cell viability of rat primary chondrocytes detected using the alamar blue assay after BNTA treatment for 1 d, 3 d, 5 d, and 7 d (n = 14 for each group; 1 d and 3 d, one-way ANOVA; 5 d and 7 d, nonparametric test). Data are shown as the mean ± standard deviation (s. d.). *<i>P</i> &lt; 0.05, **<i>P</i> &lt; 0.01.
DOI: 10.6084/m9.figshare.7813802.v1
title: Plotting a future for Amazonian canga vegetation in a campo rupestre context - Supplementary data

description: These are the supplementary data for our study on biogeography and conservation of the flora of <i>campo rupestre</i> vegetation in Brazil. We compared the differences in plant species composition and lineage distribution of <i>campos rupestres</i> in the Amazonian Carajás (Pará state) and easter Brazil (Minas Gerais and Bahia states). The study is published in the journal Plos One. <br><br><br>The supplementary data is described as follow:<br><b>S1 Fig</b> shows the flow chart of methods used in our analyses. Red symbols represent the sites with canga substrate (inedited database produced for this paper). Blue symbols represent sites with quartzite substrate and lilac symbol sites with mixed substrate (both canga and quartzite), produced for Zappi et al (2017) paper (https://doi.org/10.3389/fpls.2017.02141).<br><b>S2 Fig</b> shows the SOS values for our sites. SOS values express clades with differential over-representation of certain lineages in a set of sites, versus lineages with over-representation elsewhere (see Borregaard et al. 2014). This analysis was made with '<i>nodiv</i>' R package (https://doi.org/10.1111/2041-210X.12283).<br><br><b>S3 Fig </b>is the graph with the results of the rarefaction, extrapolation and Angiosperm species richness estimation of <i>campo rupestre </i>in Carajás. These analyses were made on software EstimateS (https://doi.org/10.1111/ecog.00814)<br><b>S4 Fig</b> brings the phylogenetic tree of all species from the campos rupestres in both Carajás and Espinhaço range in PDF format. This tree was generate in iTol (https://itol.embl.de) using the <b>S2 Text</b> file available here.<br><br><b>S1 Text</b> is the script used for all analyses done in R environment (note that some analyses were made in different software like Phylocom and EstimateS, as described in the paper).<br><b>S2 Text</b> is the dated phylogenetic tree showing evolutive relationships between all species present in our database. This tree was created in the software Phylocom based on the megatree 'R20160415.new', which is provided by Gastauer and Meira-Neto (2017) in their datapaper (https://doi.org/10.1590/0102-33062016abb0306).<br><b>S1 Table</b> contains the data matrix showing the presence of plant species in each of the 14 individual sites on mountaintops in Carajás (Pará state), which was used in the multivariate analysis, rarefaction and richness estimation for the area.<br><br><b>S2 Table</b> contains the data matrix showing the presence of plant species for each of the 14 Carajás sites plus the 14 sites of <i>campo rupestre</i> of easter Brazil (Minas Gerais and Bahia states - see Zappi et al. 2017 paper), which was used in the biogeographical comparison at national level.<br><b>S3 Table </b>brings the raw results of the rarefaction, extrapolation and species richness estimation of campo rupestre in Carajás. These analyses were made on software EstimateS (https://doi.org/10.1111/ecog.00814).<br>
DOI: 10.6084/m9.figshare.7813763
title: knockdown.bw

description: knockdown cggbp1<br>
DOI: 10.6084/m9.figshare.7813751
title: Supplementary Material for: Global Evolution of Obesity Research in Children and Youths: Setting Priorities for Interventions and Policies

description: <b><i>Background:</i></b> Childhood obesity has become a major global epidemic that causes substantial social and health burdens worldwide. The effectiveness of childhood obesity control and prevention depends largely on understanding the issue, including its current development and associated factors in a contextualized perspective. <b><i>Objectives:</i></b> Our study aimed to gauge this kind of understanding. <b><i>Methods:</i></b> We systematically searched the Web of Science database for studies concerning child obesity published up to 2017 and analyzed the volume of publications, growth rates, impact scores, collaborations, authors, affiliations, and journals. A total of 57,444 research papers were included. <b><i>Results:</i></b> The three subject categories with the highest number of papers (over 3,000) were (1) nutrition and dietetics, (2) pediatrics, and (3) public, environmental, and occupational health. We found a dramatic increase in the amount of scientific literature on childhood obesity in the past one or two decades, led by scholars from the USA – ranking at the top regarding the total number of papers (23,965 papers; 30.8%) and total number of citations (859,793 citations) – and multiple Western countries where the obesity epidemic is prevalent. <b><i>Conclusions:</i></b> The findings highlight the need for improving international and local research capacities and collaboration to accelerate knowledge production and translation into contextualized and effective childhood obesity prevention.
DOI: 10.6084/m9.figshare.7813703
title: Supplementary Table 1: Knowledge and attitudes among life scientists towards reproducibility within journal articles: a research survey

description: Supplementary Table 1: The number of respondents who were able and willing to reproduce successfully and unsuccessfully published experiments and their training received<br><br>
DOI: 10.6084/m9.figshare.7813727
title: Supplementary Material for: Identifying Features that Enhance Older Adults’ Acceptance of Robots: A Mixed Methods Study

description: <b><i>Background:</i></b> With global aging, robots are considered a promising solution for handling the shortage of aged care and companionships. However, these technologies would serve little purpose if their intended users do not accept them. While the socioemotional selectivity theory predicts that older adults would accept robots that offer emotionally meaningful relationships, selective optimization with compensation model predicts that older adults would accept robots that compensate for their functional losses. <b><i>Objective:</i></b> The present study aims to understand older adults’ expectations for robots and to compare older adults’ acceptance ratings for 2 existing robots: one of them is a more human-like and more service-oriented robot and the other one is a more animal-like and more companion-oriented robot. <b><i>Methods:</i></b> A mixed methods study was conducted with 33 healthy, community-dwelling Taiwanese older adults (age range: 59–82 years). Participants first completed a semi-structured interview regarding their ideal robot. After receiving information about the 2 existing robots, they then completed the Unified Theory of Acceptance and Use of Technology questionnaires to report their pre-implementation acceptance of the 2 robots. <b><i>Results:</i></b> Interviews were transcribed for conventional content analysis with satisfactory inter-rater reliability. From the interview data, a collection of older adults’ ideal robot characteristics emerged with highlights of humanlike qualities. From the questionnaire data, respondents showed a higher level of acceptance toward the more service-oriented robot than the more companion-oriented robot in terms of attitude, perceived adaptiveness, and perceived usefulness. From the mixed methods analyses, the finding that older adults had a higher level of positive attitude towards the more service-oriented robot than the more companion-oriented robot was predicted by higher expectation or preference for robots with more service-related functions. <b><i>Conclusion:</i></b> This study identified older adults’ preference toward more functional and humanlike robots. Our findings provide practical suggestions for future robot designs that target the older population.
DOI: 10.6084/m9.figshare.7813703.v6
title: Supplementary Table 1: Knowledge and attitudes among life scientists towards reproducibility within journal articles: a research survey

description: Supplementary Table 1: The number of respondents who were able and willing to reproduce successfully and unsuccessfully published experiments and their training received<br><br>
DOI: 10.6084/m9.figshare.7813703.v5
title: Knowledge and attitudes among life scientists towards reproducibility within journal articles_Supplementary_data_table_1

description: Supplementary Table 1: The number of respondents who were able and willing to reproduce successfully and unsuccessfully published experiments and their training received<br><br>
DOI: 10.6084/m9.figshare.7813571
title: Boundary practices of digital humanities collaborations

description: One of the defining characteristics of digital humanities is the emphasis on interdisciplinary collaboration. To coordinate across disciplinary boundaries, the development of common ground is necessary to negotiate goals and practices. Yet how such common ground can be established, and whether adoption of interdisciplinary practices and vocabularies leads participants to drift apart from their disciplinary culture, is underexplored. In this paper I investigate the boundary practices of digital humanities, referring to the interactions of scholars with cross-disciplinary collaborators and disciplinary peers, and how these are configured by disciplinary diversity and physical distance within collaborations. With an online survey, which received 173 responses, I find that the disciplinary diversity of digital humanities collaborations is often small, with participants and leadership mostly from the humanities. The physical distance is often large, increasingly relying on email. I do not find that these dimensions affect the respondents’ frequency of communication with collaborators or peers. I conclude that physical distance and disciplinary diversity cannot be confirmed to affect the frequency of boundary interactions of digital humanities. I furthermore conclude that digital humanities collaborations are biased towards the humanities, rather than a balancing of the digital and the humanities. This dataset thereby provides empirical grounding for discussions of digital humanities as a meeting between the computational domains and the humanities.
DOI: 10.6084/m9.figshare.7813544
title: New educational standards in Russia - teacher survey and interview (the lists of questions)

description: These questions were used to study the attitude of Russian teachers towards the new educational standards. The author published the following article: Khanolainen, D. (2019). Attitude of Russian teachers towards the new standards. <i>Quality Assurance in Education</i>. https://doi.org/10.1108/QAE-03-2018-0027
DOI: 10.6084/m9.figshare.7813544.v2
title: New educational standards in Russia - teacher survey and interview (the lists of questions)

description: These questions were used to study the attitude of Russian teachers towards the new educational standards. The author published the following article: Khanolainen, D. (2019). Attitude of Russian teachers towards the new standards. <i>Quality Assurance in Education</i>. https://doi.org/10.1108/QAE-03-2018-0027
DOI: 10.6084/m9.figshare.7813520
title: Zoom in to a fractal based DNA structure

description: We zoom in to a continuous Hilbert curve that has been cut into a spherical shape. This shape can serve as an effective surrogate for large scale DNA structures when conducting radiation damage simulations with the track structure code Geant4-DNA.<br>This structure is typically populated by chromatin segments such as the straight segment pictured.
DOI: 10.6084/m9.figshare.7813544.v1
title: New educational standards in Russia - teacher survey and interview (the lists of questions)

description: These questions were used to study the attitude of Russian teachers towards the new educational standards.
DOI: 10.6084/m9.figshare.7813508
title: Supplementary Material for: The Effect of Serum Neutrophil Gelatinase-Associated Lipocalin on the Discontinuation of Continuous Renal Replacement Therapy in Critically Ill Patients with Acute Kidney Injury

description: <b><i>Background:</i></b> To determine the optimal time for discontinuing continuous renal replacement therapy (CRRT) by evaluating serum neutrophil gelatinase-associated lipocalin (NGAL) in critically ill patients with acute kidney injury (AKI). <b><i>Methods:</i></b> A prospective observational study was conducted from September 2015 to March 2018. AKI patients treated with CRRT for at least 24 h were divided into “success” and “failure” groups according to their RRT requirement within 7 days after the initial discontinuation of CRRT. The prefilter and effluent NGAL concentrations were measured to calculate the sieving coefficient (SC) of NGAL in all included subjects from 0 to 72 h. <b><i>Results:</i></b> In total, 110 patients were divided into success (<i>n</i> = 78) and failure groups (<i>n</i> = 32). The mean SC of NGAL during CRRT was less than 0.05. The patients in the failure group were associated with higher mortality compared with patients in the success group (37.5 vs. 12.8%, respectively, <i>p</i> = 0.013). There were significant differences in serum NGAL, creatinine, and urine output at discontinuation. In patients without sepsis (<i>n</i> = 70), serum NGAL and urine output were significant predictors of successful cessation. The area under the receiver operating characteristic to predict the successful discontinuation of CRRT was 0.88 for NGAL and 0.86 for urine output. An NGAL level of 403 ng/mL had the highest sensitivity (81%) and specificity (89%) and a urine output of 695 mL/day had the highest sensitivity (83%) and specificity (88%). However, in septic patients (<i>n</i> = 40), urine output but not serum NGAL (OR 0.999, <i>p</i> = 0.69) was a significant variable (OR 1.002, <i>p</i> = 0.005), with a cutoff of 796 mL/day (sensitivity 83%, specificity 88%). <b><i>Conclusions:</i></b> Serum NGAL was a significant factor for predicting successful CRRT discontinuation in nonseptic AKI patients. However, urine output, rather than serum NGAL, was a significant predictor in septic AKI patients.