cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.5123461.v1
title: Supplementary Material for: How Does Inhibition of the Renin-Angiotensin System Affect the Prognosis of Advanced Gastric Cancer Patients Receiving Platinum-Based Chemotherapy?

description: <b><i>Background:</i></b> The renin-angiotensin system (RAS) is related to the regulation of cell proliferation, angiogenesis, and tumor progression. <b><i>Patients and Methods:</i></b> We retrospectively analyzed the effect of angiotensin I-converting enzyme inhibitors (ACEIs) and angiotensin II type-1 receptor blockers (ARBs) in 63 patients with advanced gastric cancer (AGC) with platinum-based chemotherapy. All patients analyzed had received medications for hypertension at the diagnosis of AGC. Patients were divided into two groups: an ACEI/ARB group (n = 30) and a non-ACEI/ARB group (n = 33). <b><i>Results:</i></b> Patient characteristics were not different between patients with and without ACEI/ARB. The response rate for all patients was 25.4% and the disease control rate was 77.8%. The median progression-free survival (PFS) for first-line chemotherapy was 5.5 months (95% CI 3.71–7.29) in the ACEI/ARB group and 4.3 months (95% CI 2.39–6.21) in the non-ACEI/ARB group (p = 0.506). There was a significant difference in overall survival (OS) in the ACEI/ARB group compared to the non-ACEI/ARB group (median OS: 8.2 vs. 13.9, p = 0.0095). In multivariate analysis, the use of ACEI/ARB was a significant independent prognostic factor for OS (p = 0.039) but not for PFS. <b><i>Conclusion:</i></b> ACEI/ARB in combination with standard chemotherapy might improve survival in patients with AGC and hypertension. These results support further investigation into the anticancer effects of ACEL/ARB.
DOI: 10.17632/yxxxphgsdn
title: Data for: Evaluating the benefits of permeate recycling in a photobioreactor using multi-component, community-level modeling

description: MATLAB m-files containing the mathematical model described in this manuscript.
DOI: 10.6084/m9.figshare.19949039.v1
title: Global database 16S metadata

description: Metadata and accession number associated to each sample used in the study.
DOI: 10.6084/m9.figshare.20223867.v1
title: Misinformation and the Big Geographic Sort

description: Past research has attributed the online circulation of misinformation to two main factors - individual characteristics (e.g., a person's information literacy) and social media effects (e.g., algorithm-mediated information diffusion) - and has overlooked a third one: the critical mass created by the offline self-segregation of Americans into like-minded geographical regions such as states (a phenomenon called "The Big Sort"). We hypothesized that this latter factor matters for the online spreading of misinformation not least because online interactions, despite having the potential of being global, end up being localized: interaction probability is known to rapidly decay with distance. Upon analysis of more than 8M Reddit comments containing news links spanning four years, from January 2016 to December 2019, we found that Reddit did not work as an "hype machine" for misinformation (as opposed to what previous work reported for other platforms, circulation was not mainly caused by platform-facilitated network effects) but worked as a supply-and-demand system: misinformation news items scaled linearly with the number of users in each state (with a scaling exponent beta=1, and a goodness of fit R2 = 0.95). Furthermore, deviations from such a universal pattern were best explained by state-level personality and cultural factors (R2 = {0.12, 0.39}), rather than socioeconomic conditions (R2 = {0.15, 0.29}) or, as one would expect, political characteristics (R2 ={0.06, 0.21}). Higher-than-expected circulation of any type of news (including reputable news) was found in states characterised by residents who tend to be less diligent in terms of their personality (low in conscientiousness) and by loose cultures understating the importance of adherence to norms (low in cultural tightness).
DOI: 10.6084/m9.figshare.3569088.v1
title: Appendix B. Derivation of fire-severity metrics from age-structure data.

description: Derivation of fire-severity metrics from age-structure data.
DOI: 10.6084/m9.figshare.5123206.v1
title: Supplementary Material for: Kompetenzerwartungen in der Ausbildung Psychologischer Psychotherapeuten und Kinder- und Jugendtherapeuten in der Verhaltenstherapie

description: Hintergrund: Die Psychotherapieausbildung wird mehr und mehr zum Gegenstand empirischer Forschung. In Deutschland hat sich die Psychotherapeutenausbildung nach Inkrafttreten des Psychotherapeutengesetzes erheblich verändert. In Bezug auf die neuen Ausbildungsgänge beginnt nun die Phase der empirischen Evaluation. Ziel der vorliegenden Studie war es, zu dieser Entwicklung im Hinblick auf die Ausbildung in der Verhaltenstherapie (VT) beizutragen. Methode: Eine Stichprobe von n = 2106 Ausbildungskandidaten in VT konnte mit einem Fragebogen zu Ausbildungsbedingungen, Ausbildungserfahrungen und subjektiven Kompetenzerwartungen in Bezug auf psychotherapeutische Kompetenzen befragt werden. Der Fragebogen wurde in Anlehnung an Instrumente zum Hochschulranking in einem mehrstufigen Prozess entwickelt. Durch hierarchische, mehrfach lineare Regressionsanalysen wurde versucht, 5 psychotherapeutische Kompetenzbereiche durch soziodemografische, ausbildungsbezogene und institutionsstrukturelle Prädiktoren vorherzusagen. Ergebnisse: Insgesamt war die erklärte Varianz gering. Ein als angemessen beurteiltes Aufwand/Nutzen-Verhältnis bei der Ausbildung und die persönliche Unterstützung durch einen kompetenten Supervisor konnten jedoch in allen untersuchten Kompetenzbereichen signifikant zur Erklärung der Varianz beitragen. Schlussfolgerungen: Um unterschiedliche Bedürfnisse von Ausbildungskandidaten zu berücksichtigen, sollten unterschiedliche Ausbildungsangebote gemacht werden. Persönliche Unterstützung in der Supervision durch einen erfahrenen Kollegen ist wesentlich für die Entwicklung einer positiven professionellen Kompetenzerwartung.
DOI: 10.17028/rd.lboro.8319884.v1
title: SAE 20 degree Notchback CAD files

description: CAD files for SAE reference model 20 degree notchback. Automotive CFD workshop 2019
DOI: 10.17632/8bw992zxs7
title: Assessing Cities' Labour Market Efficiencies using Mumbai Commuting Data
DOI: 10.17632/ds7jzd4r2m
title: Construcción de un equipo térmico para medir conductividad térmica

description: En este trabajo se presenta el diseño y la construcción de una caja caliente, con un área transversal de 46 cm x 46 cm, para determinar el coeficiente de Conductividad Térmica de hormigones con agregados de polietileno de Alta y Baja Densidad, bajo las normas ASTMC1363-11, ASTMC177-19 y la Norma nacional IRAM 11559-95. Para diseñarla se definieron las condiciones atmosféricas específicas a las que va a estar sometida en su vida útil, evaluándose también el desarrollo de nuevos materiales. La caja caliente con guarda consta de dos secciones principales: sección caliente y sección fría. La base, el techo y las paredes son de madera la cual está provista de tornillos con tuercas galvanizadas para facilitar la instalación y montaje de los diferentes tipos de probetas como de los instrumentos de medición. Con la finalidad de mantener estable la temperatura del aire y los coeficientes de trasferencia de calor, se mantienen las secciones selladas con Poliestireno Expandido bajo presión, para que las pérdidas de calor sean mínimas. Se midió la temperatura mediante termocuplas tipo K, en donde la ubicación y tolerancia de dichos instrumentos están en función de las Normas ASTM e IRAM. Los resultados alcanzados con el equipo han demostrado una concordancia satisfactoria con los valores de conductividad térmica obtenidos de las bibliografías.
DOI: 10.6084/m9.figshare.13992779.v2
title: Estrategia de busqueda

description: Search strategy
DOI: 10.6084/m9.figshare.16879780.v1
title: data set.zip

description: Cow dataset for training CNN<br><br>
DOI: 10.6084/m9.figshare.22748393.v1
title: Pleurodeles Waltl Transcriptome assembly

description: <b>Files Description:</b><b>Trinity.min200.id.fsa.gz:</b> Pleurodeles Waltl transcriptome assembly fasta file.<b>Trinity_TRANSCRIPT2GENE_NAME.zip:</b> tx2gene table, use it with tximport R package to summarize transcripts counts into genes.<b>org.Pwaltl.eg.db.zip:</b> annotation package include the GO (Gene Ontology) and KO (KEGG Orthology) terms annotation. Use it with the summarized gene counts to perform enrichment analysis using the clusterProfiler R package. [to install in R use the command:<br>devtools::install_local("path/org.Pwaltl.eg.db.zip", repos = NULL, type="source") ]<b>trinotate_annotation_report.uniq.xls.gz:</b> Full annotation report from trinotate workflow (Swiss-Prot and TrEMBL, Pfam, GO terms, etc).<b>Trinity.cds.fsa.gz</b>, <b>Trinity.pep.fsa.gz:</b> ORF prediction and protein using transdecoder.<b>Limb_gene_counts_tximport.xlsx:</b> gene abundances and counts using tximport package with tx2gene table.<b>Limb_DEG.xlsx:</b> Differentially expressed genes in different limb stages when compared to 0dpa.<b>Limb_Enrichment_BP_KO.xlsx:</b> GO Biological Processes GSEA, and KO ortholog GSEA results in different limb stages when compared to 0dpa.<b>Commands.txt:</b> key commands used in the assembly process.<b>all_tissues_gene_counts_raw</b>: gene counts for all tissues analyzed.<b>all_tissues_gene_counts_vst</b>: VST counts for all tissues analyzed using DESeq2 package.<br><b>Abstract:</b>In this study, we present an updated transcriptome assembly for the Iberian ribbed newt, Pleurodeles waltl (<i>P. waltl</i>), a widely used model organism in regeneration research. The existing publicly available transcriptome for this species is limited by the inclusion of only three libraries from the limb and two from the heart, tissues of particular interest for regeneration studies. Additionally, the previous annotation was limited, reducing the utility of the dataset for further in-depth research. To provide a more complete transcriptome with a more comprehensive annotation, we utilized 58 previously published and 9 newly sequenced libraries, expanding the available transcriptomic data for key tissues, especially limb and heart tissues. Our assessment demonstrates that the new assembly offers a more comprehensive representation of reads and proteins compared to previous versions. Furthermore, we significantly improved the functional annotation by using the Trinotate pipeline, which includes the identification of complete ORFs, Pfam motifs, gene names, GO terms, and KEGG Orthology, facilitating more robust transcriptomic analyses. We also examined various stages of limb regeneration and development, gaining insights into the key signaling pathways involved. This work provides a valuable resource for researchers investigating the molecular mechanisms underlying <i>P. waltl</i><i>'s</i> regenerative abilities, enabling more detailed gene expression studies and broader biological insights.
DOI: 10.6084/m9.figshare.27195357.v1
title: <b>The immune response of </b><b><i>Thitarodes xiaojinensis</i></b><b> to the disruption of intestinal barrier by </b><b><i>Ophiocordyceps sinensis</i></b>

description: 昆虫病原真菌 （EPF） <i>Ophiocordyceps sinensis</i> 与其宿主昆虫 <i>Thitarodes xiaojinensis</i>，<i> </i>使其成为<i> </i>它<i> </i>宿主-病原体相互作用的独特模型。然而，<i>T. xiaojinensis </i>和 <i>O. sinensis </i>仍不清楚。在这项研究中，我们进行了多组学方法来阐明 <i>O. sinensis</i> 和 <i>T. xiaojinensis</i>。我们发现 <i>O. sinensis</i> 对昆虫的肠道屏障造成损害，并促进细菌从肠道转移到血腔。然后，<i> O. sinensis</i> 和其他机会性病原菌的存在破坏了血淋巴微生物群的稳态，导致细菌多样性增加。<b> </b>结果，昆虫的激素水平（特别是 20-羟基蜕皮激素和保幼激素）增加，其抗氧化能力（总抗氧化能力和谷胱甘肽 S-转移酶）以及作为其免疫反应一部分的抗菌肽 （AMP） 的产生也增加了。当被 O. sinensis 感染时，宿主体内 20E 水平升高 <i>中华蚜</i> 可能导致 AMPs 的产生增加。我们的研究结果表明，<i>O. sinensis</i> 激活和操纵昆虫的免疫反应，以抵抗肠道微生物群侵入血淋巴。这些结果表明，昆虫的微生物组调节 EPF 与其宿主之间的免疫相互作用，揭示了 <i>O. sinensis</i> 和<i> T</i><i> 小金人。</i>.
DOI: 10.6084/m9.figshare.28638962.v1
title: Supplementary Material for: An Unusual Complication of Diverticular Bleed: Dysphagia and Food Impaction from Black Esophagus

description: Acute esophageal necrosis, or black esophagus, is a rare clinical phenomenon typically seen in older men after an acute triggering event. It may present with dysphagia due to stricturing or dysmotility, a complication of severe esophageal inflammation. Here we describe a case of a woman with several cardiovascular risk factors who developed black esophagus following diverticular-related hemorrhagic shock and presented with chest pain followed by dysphagia and food impaction likely as a result of mucosal sloughing and altered esophageal motility. The diagnosis was confirmed endoscopically and pathology revealed coagulative necrosis due to ischemia. Acute esophageal necrosis should be suspected in patients with cardiovascular risk factors and hemodynamic compromise, and may be confirmed with endoscopy. As dysphagia may complicate this condition, slow advancement of diet while healing is advised.
DOI: 10.6084/m9.figshare.28836407.v1
title: Transition of the D3c branch and novel recombination events contribute to the diversity of Coxsackievirus A6 in Beijing, China, from 2019 to 2023

description: Coxsackievirus A6 (CVA6) is a major pathogen responsible for numerous outbreaks of hand, foot, and mouth disease (HFMD) worldwide since 2008. This study investigates the molecular evolution and recombination of CVA6 in Beijing, China. Full-length sequences of 54 CVA6 from Beijing (2019–2023) were obtained through metagenomic next-generation sequencing (mNGS) and Sanger sequencing. These sequences were compared with representative sequences from GenBank to analyze their phylogenetic characteristics, recombination diversity, and evolutionary dynamics. The 54 CVA6 samples co-circulated with samples from multiple provinces in China, as well as from South Korea and Japan. Phylogenetic analysis revealed a novel D3c branch, with the VP1 T283A amino acid mutation identified as a key change in its formation. One sequence belonged to the D3a branch, while 53 sequences belonged to the D3c branch. Recombination analysis identified RF-A (46, 85.1%) and three novel recombinant forms (RFs): RF-Z (1, 1.9%), RF-AA (1, 1.9%), and RF-AB (6, 11.1%). Bayesian phylogenetic analysis estimated that the most recent common ancestor (tMRCA) of D3c emerged in 2013 (95% HPD: 2012–2014), with recombination events occurring in RF-Z (2017–2019), RF-AA (2019–2023), and RF-AB (2021–2023). In conclusion, we revealed a globally circulating CVA6 D3c branch and identified three novel recombinant lineages, providing valuable insights for the intervention and control of HFMD.
DOI: 10.6084/m9.figshare.7637504.v1
title: Hepatocyte-specific loss of GPS2 in mice reduces non-alcoholic steatohepatitis via activation of PPARα

description: Obesity triggers the genesis of non-alcoholic fatty liver diseases (NAFLD), which involves alterations of regulatory transcription networks and of hepatocyte-selective epigenomes. Here we demonstrate that G protein pathway suppressor 2 (GPS2), a subunit of the nuclear receptor corepressor (NCOR)/ histone deacetylase 3 (HDAC3) complex, is a central component of such networks and accelerates the progression of NAFLD towards non-alcoholic steatohepatitis (NASH). Hepatocyte-specific Gps2 knockout in mice alleviates the development of diet-induced steatosis and fibrosis and causes activation of lipid catabolic genes. Integrative cistrome, epigenome and transcriptome analysis identifies the lipid-sensing peroxisome proliferator-activated receptor alpha (PPARa, NR1C1) as a direct GPS2 target. Liver gene expression data from human patients reveal that GPS2 expression positively correlates with a NASH/fibrosis gene signature. Collectively, our data suggest that the GPS2-PPARa partnership in hepatocytes coordinates the progression of NAFLD in mice and in humans and thus might be therapeutically important.
DOI: 10.17632/9cgf9hnxh6
title: candesartan cilexetil tablets stability

description: stability data for 21 production scale batches, four containers, five stability conditions and nine stability time points . Two degradation products are monitored.
DOI: 10.17632/bcf46py5dh
title: Data for: Predicting New Iron Garnet Thin Films with Perpendicular Magnetic Anisotropy

description: These files contain the MATLAB scripts used for generating the supplementary plots and Figure 5 of our manuscript. The Excel file contains the formulae and each anisotropy calculation for all 50 cases.
DOI: 10.17632/hg7sd7hbk5
title: Multiparametric senescent cell phenotyping reveals CD24 osteolineage cells as targets of senolytic therapy in the aged murine skeleton

description: In the present study we leverage the power of mass cytometry by time-of-flight (CyTOF) to define, at the single-cell level, mesenchymal bone and marrow senescent cells in mice. Specifically, rather than relying principally on p16 or p21 expression, we used multiple criteria to define senescent cells. We assessed senescent cell burden in established skeletal cell populations and tested their susceptibility to senolytic clearance through either genetic or pharmacologic approaches.
DOI: 10.6084/m9.figshare.21922017.v1
title: raw data.zip

description: All the raw data in the manuscript.
DOI: 10.6084/m9.figshare.25769379.v1
title: Instances for the "Constraint programming and matheuristic for the capacitated family traveling salesman problem" article

description: The Capacitated Family Search Traveling Salesperson Problem (CFTSP) is a variant of the Family Traveling Salesperson Problem. The CFTSP is modeled by a graph in which its nodes are classified into disjoint families. The problem is to visit a given quantity of nodes of each family using a set of capacitated agents to minimize the total traveled distance. To address this problem, we propose an exact method based on a constraint programming model and a matheuristic based on a reactive Greedy Randomized Adaptive Search Procedure with probabilistic stop criteria to solve larger instances in a reasonable time. The Experimental results obtained by exact and non-exact methods are presented and compared.
DOI: 10.6084/m9.figshare.5420986.v1
title: TversicolorDimorphism_GFclustering.tar.gz

description: Tetragnatha versicolor venom dimorphism gene family clustering results and associated files.
DOI: 10.17632/5f7xcv8dgv
title: Providing adjoint optimized GEKO model coefficients for film cooling predictions of trench designs.

description: The data represent coefficients for the Generalized k-omega (GEKO) turbulence model used to solve the Reynolds-averaged Navier-Stokes equations (RANS) of wall-bounded film cooling flows involving the trench design. This model, with these coefficients, can be applied in Computational Fluid Dynamics (CFD) simulations using the commercial solver Ansys Fluent (version 2022 R1 or higher). The coefficients were tuned to match the 3D temperature field (temporal-averaged) of a Large Eddy Simulation (LES). The CFD case simulated for the RANS and LES was based on an optimized trench design by Peter Schreivogel at a momentum ratio of I=1 and a density ratio of 2. The LES and resulting RANS solution predicted the experimental results of Peter Schreivogel's optimized trench design and the transverse trench at I=1. At I=8, the tuned GEKO model still led to a better prediction than the standard model, but it was not as accurate as at I=1.
DOI: 10.17632/8cjchphss5
title: Impact of Atal Tunnel and Rohtang Ropeway Project on the Tourism Industry in Manali, Himachal Pradesh.

description: This Data was collected as a survey. The survey form was designed on and filled using "Google Forms". Through this survey, we tried to look into peoples' experience about Atal Tunnel Impact on Tourism in Manali and how the propective Rohtang Ropeway project would impact the Tourism Industry.  
All the Respondents were associated with the Tourism Industry like Hoteliers, Taxi Drivers, Travel Agents, Adventure Tour operators, etc. 
The Data on the result of this survey is given in the ".csv" file format. Also, One link is provided to see the summary of this survey through the use of Graphs and lists.  I would suggest any person who is interested in the results, kindly first look at the summary provided through this link. This would make you comfortable in understanding the questions used in the survey and the summary of all responses. 
Kindly feel free to contact me, if you come across any inconveniences in understanding this or need to discuss anything related to this Data Set  (sahilsharmahimalaya@gmail.com).
DOI: 10.6084/m9.figshare.21173773.v1
title: Supplementary Table 4

description: This table showed common robustly up- or down-regulated genes in mouse and rat DRGs upon PNI.
DOI: 10.6084/m9.figshare.5126350.v1
title: Supplementary Material for: Characterization of T Cell Epitopes in Bovine α-Lactalbumin

description: <b><i>Background:</i></b> Recent studies have indicated that peptides containing T cell epitopes may be used for immunotherapy. While for several cow's milk allergens the T cell epitopes have been described, the T cell epitopes in the major allergen α-lactalbumin (α-LAC) are unknown. Therefore, the aim of this study was to determine the T cell epitopes in α-LAC. <b><i>Methods:</i></b> Nineteen synthetic peptides spanning α-LAC were obtained. Cow's milk-specific T cell lines (TCLs) of 46 subjects were generated and tested for their specificity for α-LAC. The lines responding to α-LAC were subsequently tested to determine their activation in response to the peptides. <b><i>Results:</i></b> More than half of the TCLs generated did not respond to α-LAC or lost their responsiveness during subsequent experiments, which indicates that α-LAC has low immunogenicity. Only 8 TCLs recognized 1 or more peptides. The recognition of the peptides was diverse and no major epitopes could be defined. <b><i>Conclusion:</i></b> The immunogenicity of α-LAC is very low compared to other major allergens in cow's milk. Moreover, there seems to be no dominant epitope present in the protein. Therefore, it seems unlikely that peptides of this protein can be used for immunotherapy.
DOI: 10.17632/nppwbkdf85
title: UAV footage of Merino sheep in South Africa

description: This datasets comprises aerial footage of Merino sheep captured by a UAV. This dataset includes both image and video data. The video dataset consists of both a development and a testing dataset. The dataset was collected over a period of 11 months in two locations in South Africa at a height of 30 m above ground. A DJI Mavic Air 2 was used for data collection. The onboard camera has a 0.5-inch CMOS sensor with a width of 13.2 mm and the lens has a focal length of 8.8 mm. The images were captured at a resolution of 4000 x 3000 while videos were captured at a resolution of 3840 x 2160 and 1920 x 1080 at 30 fps. 

The image dataset comprises 125 images, totaling 4848 individual instances of sheep. On the other hand, the video dataset includes a development set with 19 videos (4521 unique frames) and a testing set with 10 videos (3045 unique frames). One video containing 250 frames can be excluded from the dataset due to inconsistencies in data representation and blurry frames.
DOI: 10.6084/m9.figshare.19526092.v11
title: Chiral DES database

description: This is a database of mixtures of hydrogen bond acceptors (HBA) and chiral hydrogen bond donors (HBD) to screen for potential deep eutectic solvent (DES) formation. Mole ratios of HBA-HBD were mixed and heated to 55 C for ~ 2 hours. The mixtures were then allowed to cool to 20 C. The results are recorded in the database as yes (liquid), no (solid), or partial (mostly liquid with some solid). All HBA and HBDs are entered by chemical name and by isomeric SMILES.Latest uploaded version (32824) is the same database as the previous version (72423), but has an added search function on a second tab. If you are looking for a CSV version of the database use Chiral DES Database-72423.csv.