cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.21624556
title: A Network Pharmacological Approach to Explore the Mechanisms of TongXieYaoFang in Inflammatory Bowel Disease

description: Abstract Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the intestine, demonstrating an increasing incidence every year. TongXieYaoFang (TXYF) has been used widely in China as a complementary therapy to relieve the symptoms of IBD for hundreds of years. In the present research, a network pharmacology-based approach was used to systematically explore the intrinsic mechanisms of TXYF in IBD at the molecular level. Network pharmacology-based methods, which mainly included database mining, screening of bioactive compounds, target prediction, collection of IBD-related targets, gene enrichment analysis, network construction, and molecular docking, were employed in the present study. Network analysis revealed a total of 108 potential targets derived from 22 component compounds of TXYF, among which 34 targets were common with the IBD-related targets. In the protein-protein interaction (PPI) network, 10 key targets were identified. The gene enrichment analysis suggested that anti-inflammatory processes, such as NF-kappa B signaling pathway and Toll-like receptor signaling pathway, could be the core processes involved in the action of TXYF in IBD. Molecular docking results revealed that three compounds present in TXYF exhibited strong binding affinity for PTGS2. The present study provides novel insights into the molecular mechanisms and network approaches of TXYF action in IBD from a systemic perspective. The potential targets and pathways identified in the present study would assist in further research on the clinical application of TXYF in IBD therapy.
DOI: 10.6084/m9.figshare.21624556.v1
title: A Network Pharmacological Approach to Explore the Mechanisms of TongXieYaoFang in Inflammatory Bowel Disease

description: Abstract Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the intestine, demonstrating an increasing incidence every year. TongXieYaoFang (TXYF) has been used widely in China as a complementary therapy to relieve the symptoms of IBD for hundreds of years. In the present research, a network pharmacology-based approach was used to systematically explore the intrinsic mechanisms of TXYF in IBD at the molecular level. Network pharmacology-based methods, which mainly included database mining, screening of bioactive compounds, target prediction, collection of IBD-related targets, gene enrichment analysis, network construction, and molecular docking, were employed in the present study. Network analysis revealed a total of 108 potential targets derived from 22 component compounds of TXYF, among which 34 targets were common with the IBD-related targets. In the protein-protein interaction (PPI) network, 10 key targets were identified. The gene enrichment analysis suggested that anti-inflammatory processes, such as NF-kappa B signaling pathway and Toll-like receptor signaling pathway, could be the core processes involved in the action of TXYF in IBD. Molecular docking results revealed that three compounds present in TXYF exhibited strong binding affinity for PTGS2. The present study provides novel insights into the molecular mechanisms and network approaches of TXYF action in IBD from a systemic perspective. The potential targets and pathways identified in the present study would assist in further research on the clinical application of TXYF in IBD therapy.
DOI: 10.6084/m9.figshare.22148855
title: Scalable Model-Free Feature Screening via Sliced-Wasserstein Dependency

description: We consider the model-free feature screening problem that aims to discard non-informative features before downstream analysis. Most of the existing feature screening approaches have at least quadratic computational cost with respect to the sample size <i>n</i>, thus, may suffer from a huge computational burden when <i>n</i> is large. To alleviate the computational burden, we propose a scalable model-free sure independence screening approach. This approach is based on the so-called sliced-Wasserstein dependency, a novel metric that measures the dependence between two random variables. Specifically, we quantify the dependence between two random variables by measuring the sliced-Wasserstein distance between their joint distribution and the product of their marginal distributions. For a predictor matrix of size <i>n</i> × <i>d</i>, the computational cost for the proposed algorithm is at the order of O(n log (n)d), even when the response variable is multivariate. Theoretically, we show the proposed method enjoys both sure screening and rank consistency properties under mild regularity conditions. Numerical studies on various synthetic and real-world datasets demonstrate the superior performance of the proposed method in comparison with mainstream competitors, requiring significantly less computational time. Supplementary materials for this article are available online.
DOI: 10.6084/m9.figshare.22148855.v1
title: Scalable model-free feature screening via sliced-Wasserstein dependency

description: We consider the model-free feature screening problem that aims to discard non-informative features before downstream analysis. Most of the existing feature screening approaches have at least quadratic computational cost with respect to the sample size <i>n</i>, thus may suffer from a huge computational burden when <i>n</i> is large. To alleviate the computational burden, we propose a scalable model-free sure independence screening approach. This approach is based on the so-called sliced-Wasserstein dependency, a novel metric that measures the dependence between two random variables. Specifically, we quantify the dependence between two random variables by measuring the sliced-Wasserstein distance between their joint distribution and the product of their marginal distributions. For a predictor matrix of size <i>n</i> × <i>d</i>, the computational cost for the proposed algorithm is at the order of O(n log (n)d), even when the response variable is multivariate. Theoretically, we show the proposed method enjoys both sure screening and rank consistency properties under mild regularity conditions. Numerical studies on various synthetic and real-world datasets demonstrate the superior performance of the proposed method in comparison with mainstream competitors, requiring significantly less computational time.
DOI: 10.6084/m9.figshare.6944942.v1
title: Additional file 2: of Consensus genetic linkage map construction and QTL mapping for plant height-related traits in linseed flax (Linum usitatissimum L.)

description: SNP marker information for consensus linkage map from PH and MH populations (XLSX 712 kb)
DOI: 10.6084/m9.figshare.17430339.v1
title: Petrogenesis of the Early Silurian Renda appinite suite in the southeastern Qilian Orogen, NW China: Implications for the evolution of a Proto-Tethys magmatic arc

description: Early Paleozoic subduction beneath peri-Gondwana microcontinents formed a major Proto-Tethys magmatic arc system. Appinite suite rocks constitute important components within that magmatic arc. Herein, we report hornblende <sup>40</sup>Ar/<sup>39</sup>Ar and zircon U–Pb geochronology data, zircon Hf isotope, mineral chemistry, whole-rock geochemistry, and Sr–Nd–Pb isotope data for the rocks of hornblende gabbro-diorite-quartz diorite-quartz monzodiorite from the Renda appinite suite and adjacent granite porphyry in the southeastern Qilian Orogen. Hornblende <sup>40</sup>Ar/<sup>39</sup>Ar and zircon U–Pb isotopic data constrain ages of the intrusions of the Renda appinite suite to 439–435 Ma. Rocks in this suite represent the calc-alkalic to alkali-calcic series, and they are enriched in large-ion lithophile elements and depleted in high-field-strength elements. The hornblende gabbros exhibit moderate initial <sup>87</sup>Sr/<sup>86</sup>Sr ratios (0.7046–0.7055) and higher whole-rock ε<sub>Nd</sub>(t) (–1.3 to +1.7) and zircon ε<sub>Hf</sub>(t) (+7.2 to +11.2) values relative to the other rocks of the suite (0.7047–0.7064, – 7.7 to – 1.1, and – 6.6 to +6.8, respectively) as well as Pb isotopic features similar to EM2 lithospheric mantle. These geochemical characteristics suggest that the Renda appinite suite originates from partial melting of an enriched lithospheric mantle, with subsequent fractional crystallization and hybridization with crustal components. The granite porphyry formed by partial melting of the crust coeval with the emplacement of juvenile magma. This study suggests emplacement occurred during a short-lived collision with slab failure (breakoff) after latest stage (cessation) of Proto-Tethys oceanic subduction along the northern side of the southeastern Qilian Orogen. The heat supplied by the asthenospheric upwelling through a gap in the subducted slab induced melting in lithospheric mantle and deep crust producing Renda appinite suite rocks and granite porphyry.
DOI: 10.6084/m9.figshare.22148855.v2
title: Scalable Model-Free Feature Screening via Sliced-Wasserstein Dependency

description: We consider the model-free feature screening problem that aims to discard non-informative features before downstream analysis. Most of the existing feature screening approaches have at least quadratic computational cost with respect to the sample size <i>n</i>, thus, may suffer from a huge computational burden when <i>n</i> is large. To alleviate the computational burden, we propose a scalable model-free sure independence screening approach. This approach is based on the so-called sliced-Wasserstein dependency, a novel metric that measures the dependence between two random variables. Specifically, we quantify the dependence between two random variables by measuring the sliced-Wasserstein distance between their joint distribution and the product of their marginal distributions. For a predictor matrix of size <i>n</i> × <i>d</i>, the computational cost for the proposed algorithm is at the order of O(n log (n)d), even when the response variable is multivariate. Theoretically, we show the proposed method enjoys both sure screening and rank consistency properties under mild regularity conditions. Numerical studies on various synthetic and real-world datasets demonstrate the superior performance of the proposed method in comparison with mainstream competitors, requiring significantly less computational time. Supplementary materials for this article are available online.
DOI: 10.6084/m9.figshare.6944951
title: Additional file 3: of Consensus genetic linkage map construction and QTL mapping for plant height-related traits in linseed flax (Linum usitatissimum L.)

description: Detailed environmental information of the 4 locations (XLSX 9 kb)
DOI: 10.6084/m9.figshare.22148883.v1
title: Anterior segment inflammation and its association with dry eye parameters following myopic SMILE and FS-LASIK

description: To evaluate dry eye and anterior segment inflammation after small incision lenticule extraction (SMILE) and femtosecond laser-assisted <i>in situ</i> keratomileusis (FS-LASIK), and investigate their association. This prospective and observational study included 96 eyes from 48 myopic patients. The evaluation was performed at baseline, postoperative day 1, week 1, month 1 and month 3. Outcome measures included anterior chamber flare, bulbar redness (BR), limbal redness (LR), ocular surface disease index (OSDI), tear meniscus height (TMH), the first and average noninvasive breakup time (NIBUT-1, NIBUT-a), fluorescein breakup time (FBUT), corneal fluorescein staining (CFS), and Schirmer I. Generalized estimating equations (GEEs) were applied to explore the correlation between flare and ocular surface parameters. Flare increased significantly in both groups at day 1 and week 1 and then returned to baseline at month 1. In both groups, BR decreased on day 1 and then gradually increased towards the baseline. In FS-LASIK, LR was lower than baseline at day 1 and month 3. An increase in OSDI was found in the SMILE group on day 1, and in the FS-LASIK group at day 1 to month 1. NIBUT-1 and NIBUT-a decreased significantly on day 1 in both groups. At month 3, NIBUT-a did not return to baseline in FS-LASIK. CFS increased significantly at week 1 in both groups. All parameters were comparable between SMILE and FS-LASIK except for OSDI and NIBUT-a. Time and spherical equivalent showed a correlation with flare. Both SMILE and FS-LASIK induced elevated anterior chamber flare and dry eye. However, flare might not be considered a factor determining perioperative dry eye.Key MessagesDry eye disease is common after corneal refractive surgery. Signs and symptoms of dry eye disease persist longer after FS-LASIK compared with SMILE.Both FS-LASIK and SMILE transiently disrupted blood-aqueous barrier integrity, leading to anterior segment inflammation.Anterior chamber flare might not be considered a factor explaining perioperative dry eye, other biomarkers remain for future exploration. Dry eye disease is common after corneal refractive surgery. Signs and symptoms of dry eye disease persist longer after FS-LASIK compared with SMILE. Both FS-LASIK and SMILE transiently disrupted blood-aqueous barrier integrity, leading to anterior segment inflammation. Anterior chamber flare might not be considered a factor explaining perioperative dry eye, other biomarkers remain for future exploration.
DOI: 10.6084/m9.figshare.6944942
title: Additional file 2: of Consensus genetic linkage map construction and QTL mapping for plant height-related traits in linseed flax (Linum usitatissimum L.)

description: SNP marker information for consensus linkage map from PH and MH populations (XLSX 712 kb)
DOI: 10.6084/m9.figshare.14285292
title: A META-ANALYSIS OF THE EFFECTS OF GREEN TEA COMBINED WITH PHYSICAL ACTIVITY ON BLOOD LIPIDS IN HUMANS

description: ABSTRACT Introduction: Most studies of green tea extract (GTE) combined with physical activity have reported a preventative effect for cardiovascular disease; however, the findings regarding the effects on serum lipids are controversial. Objective: This meta-analysis aimed to examine the evidence of the effects of GTE combined with physical activity on the serum lipid content in humans. Methods: In June 2017, we conducted electronic searches of PubMed, Web of Science, and Cochrane Library to identify pertinent studies: those with an experiment period exceeding two weeks, human randomized controlled trials (RCTs), and those that only assessed GTE with physical activity were included. A random effects model meta-analysis was used in this review. Results: A total of 271 citations were retrieved in our search of the electronic literature, and 7 RCTs, which included 608 individuals, were identified. Overall, there was no significant decrease in low-density lipoprotein cholesterol (LDL-C) (SMD:-0.169; 95% confidence interval [CI]:-0.414 to 0.076; I2=22.7%; p=0.177) or total cholesterol (TC) levels between the GTE and placebo combined with the physical activity group. Similar results were also observed for high density-lipoprotein cholesterol (HDL-C) and triglycerides (TG). In the subgroup and sensitivity analyses of the five studies, the TC levels of the subjects who received a lower dose of epigallocatechin gallate (EGCG) together with performing physical activity were significantly decreased. Conclusion: Current evidence suggests that green tea combined with physical activity does not improve the lipid and lipoprotein levels in humans. Level of evidence I; Systematic review.
DOI: 10.6084/m9.figshare.17430339
title: Petrogenesis of the Early Silurian Renda appinite suite in the southeastern Qilian Orogen, NW China: Implications for the evolution of a Proto-Tethys magmatic arc

description: Early Paleozoic subduction beneath peri-Gondwana microcontinents formed a major Proto-Tethys magmatic arc system. Appinite suite rocks constitute important components within that magmatic arc. Herein, we report hornblende <sup>40</sup>Ar/<sup>39</sup>Ar and zircon U–Pb geochronology data, zircon Hf isotope, mineral chemistry, whole-rock geochemistry, and Sr–Nd–Pb isotope data for the rocks of hornblende gabbro-diorite-quartz diorite-quartz monzodiorite from the Renda appinite suite and adjacent granite porphyry in the southeastern Qilian Orogen. Hornblende <sup>40</sup>Ar/<sup>39</sup>Ar and zircon U–Pb isotopic data constrain ages of the intrusions of the Renda appinite suite to 439–435 Ma. Rocks in this suite represent the calc-alkalic to alkali-calcic series, and they are enriched in large-ion lithophile elements and depleted in high-field-strength elements. The hornblende gabbros exhibit moderate initial <sup>87</sup>Sr/<sup>86</sup>Sr ratios (0.7046–0.7055) and higher whole-rock ε<sub>Nd</sub>(t) (–1.3 to +1.7) and zircon ε<sub>Hf</sub>(t) (+7.2 to +11.2) values relative to the other rocks of the suite (0.7047–0.7064, – 7.7 to – 1.1, and – 6.6 to +6.8, respectively) as well as Pb isotopic features similar to EM2 lithospheric mantle. These geochemical characteristics suggest that the Renda appinite suite originates from partial melting of an enriched lithospheric mantle, with subsequent fractional crystallization and hybridization with crustal components. The granite porphyry formed by partial melting of the crust coeval with the emplacement of juvenile magma. This study suggests emplacement occurred during a short-lived collision with slab failure (breakoff) after latest stage (cessation) of Proto-Tethys oceanic subduction along the northern side of the southeastern Qilian Orogen. The heat supplied by the asthenospheric upwelling through a gap in the subducted slab induced melting in lithospheric mantle and deep crust producing Renda appinite suite rocks and granite porphyry.
DOI: 10.6084/m9.figshare.6944951.v1
title: Additional file 3: of Consensus genetic linkage map construction and QTL mapping for plant height-related traits in linseed flax (Linum usitatissimum L.)

description: Detailed environmental information of the 4 locations (XLSX 9 kb)
DOI: 10.6084/m9.figshare.17430512.v1
title: Type IIA topoisomerase (TOP2A) triggers epithelial-mesenchymal transition and facilitates HCC progression by regulating Snail expression

description: Type IIA topoisomerase (TOP2A) is upregulated in hepatocellular carcinoma (HCC) and its expression is positively correlated with poor prognosis. However, the underlying molecular mechanism of this connection are poorly understood. Hence, the present work aimed to examine the possible mechanisms which may be useful in identifying a potential therapeutic strategy. The differential expression of TOP2A mRNA in HCC as compared with adjacent normal tissue was analyzed using the Oncomine database. The expression levels of TOP2A in HCC specimens and cell lines were assessed by Western blot and RT-qPCR. Stable cell lines were generated to knockdown or overexpress TOP2A, and then cell growth, migration, and invasion were analyzed. Furthermore, this study examined epithelial-mesenchymal transition (EMT) as well as the activation of related pathways. Additionally, the correlation between TOP2A levels and E-cadherin/Snail expression was determined in 72 HCC specimens. Higher expression levels of TOP2A were observed in HCC in Oncomine datasets, and the results were verified using 40 pairs of HCC specimens and peritumoral tissues. TOP2A expression levels were remarkably elevated in cells with great metastatic capacity. In addition, HCC cell growth, migration, and invasion were suppressed after TOP2A knockdown in MHCC97H cells (MHCC97H-shRNA-TOP2A), while these capabilities were promoted in TOP2A-overexpressing Hep3B cells (Hep3B-TOP2A). Furthermore, EMT was inhibited in MHCC97H-shRNA-TOP2A cells, but induced in Hep3B-TOP2A cells. The induction of EMT by TOP2A was shown to be mediated by Snail, as TOP2A promoted Snail expression through the p-ERK1/2/p-SMAD2 signaling pathway. TOP2A level showed a negative correlation with E-cadherin, whereas a positive correlation with that of vimentin and Snail in human HCC specimens by immunohistochemistry analyses. Kaplan–Meier survival curves revealed that TOP2A upregulation showed a positive correlation with poor prognosis patients. Taken together, TOP2A possibly enhances the metastasis of HCC by promoting EMT through the mediation of the p-ERK1/2/p-SMAD2/Snail pathway. This indicates that TOP2A maybe a potential factor to predict the prognosis of HCC.
DOI: 10.6084/m9.figshare.14285388
title: COLLEGE STUDENTS’ PHYSICAL AND MENTAL HEALTH EXERCISE BASED ON TENNIS

description: ABSTRACT College students are often under great pressure, and their physical and mental health is the focus of attention in college education. In order to cultivate high-quality talents and relieve the pressure of college students, many colleges and universities have set up a variety of sports courses, including tennis courses. Analyzing the influence of tennis on the physical and mental health of college students, this study studies the situation of college students participating in tennis by consulting literature, designing questionnaires and using an experimental measurement method, while it constructs the physical health evaluation index and mental health evaluation index of college students. On this basis, this study evaluates the influence of tennis on students’ physical and mental health. The results show that tennis has a positive impact on the physical and mental health of college students. Tennis can not only enhance college students’ cardiopulmonary function and muscle strength, but also cultivate students’ independent personality, eliminate depression tendency, make students independent, flexible and active, which is conducive to the development of students’ mental health. It is hoped that this study can provide some reference for the research of college students’ physical and mental health exercise based on tennis.
DOI: 10.6084/m9.figshare.14285396.v1
title: HUMAN REMOTE MOBILE MEDICAL INFORMATION COLLECTION METHOD BASED ON INTERNET OF THINGS AND INTELLIGENT ALGORITHM

description: ABSTRACT In the environment of rapid social and economic development, the reform of medical informatization is constantly advancing, and the residents pay more and more attention to their own health status while improving their living standards. The traditional medical service system has some disadvantages in providing real-time, cross regional, long-term and easy-to-operate health services, which has become increasingly inadequate to meet the health needs of users. In order to solve the problem of difficulty in seeing a doctor caused by limited medical resources, and to carry out real-time health monitoring for a large number of groups suffering from chronic diseases and sub-health groups, this study conducted in-depth analysis and experimental exploration on the human remote mobile medical information collection method based on the Internet of things and intelligent algorithm. It established the information collection section by using KbaC clustering algorithm based on ant colony point system which, combined with a comparative study on the health indicators of related groups, has successfully proved that the Internet of things technology and intelligent algorithm for medical information collection and follow-up medical services are of certain positive significance, based on the Internet of things and other related technologies of human remote medical information collection system that can accurately and timely detect the patient's blood pressure, blood sugar and other health data, and then provide corresponding medical services.