cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.5281/zenodo.4161645
title: Phylogenomics reveals an extensive history of genome duplication in diatoms (Bacillariophyta)

description: Abstract Premise of the Study Diatoms are one of the most species‐rich lineages of microbial eukaryotes. Similarities in clade age, species richness, and primary productivity motivate comparisons to angiosperms, whose genomes have been inordinately shaped by whole‐genome duplication (WGD). WGDs have been linked to speciation, increased rates of lineage diversification, and identified as a principal driver of angiosperm evolution. We synthesized a large but scattered body of evidence that suggests polyploidy may be common in diatoms as well. Methods We used gene counts, gene trees, and distributions of synonymous divergence to carry out a phylogenomic analysis of WGD across a diverse set of 37 diatom species. Key Results Several methods identified WGDs of varying age across diatoms. Determining the occurrence, exact number, and placement of events was greatly impacted by uncertainty in gene trees. WGDs inferred from synonymous divergence of paralogs varied depending on how redundancy in transcriptomes was assessed, gene families were assembled, and synonymous distances (Ks) were calculated. Our results highlighted a need for systematic evaluation of key methodological aspects of Ks‐based approaches to WGD inference. Gene tree reconciliations supported allopolyploidy as the predominant mode of polyploid formation, with strong evidence for ancient allopolyploid events in the thalassiosiroid and pennate diatom clades. Conclusions Our results suggest that WGD has played a major role in the evolution of diatom genomes. We outline challenges in reconstructing paleopolyploid events in diatoms that, together with these results, offer a framework for understanding the impact of genome duplication in a group that likely harbors substantial genomic diversity.
description: Transcriptome assemblies (DNA and corresponding amino acid sequences) used in genome duplication analyses.
DOI: 10.5281/zenodo.3588373
title: Phylogenomics reveals an extensive history of genome duplication in diatoms (Bacillariophyta)

description: Abstract Premise of the Study Diatoms are one of the most species‐rich lineages of microbial eukaryotes. Similarities in clade age, species richness, and primary productivity motivate comparisons to angiosperms, whose genomes have been inordinately shaped by whole‐genome duplication (WGD). WGDs have been linked to speciation, increased rates of lineage diversification, and identified as a principal driver of angiosperm evolution. We synthesized a large but scattered body of evidence that suggests polyploidy may be common in diatoms as well. Methods We used gene counts, gene trees, and distributions of synonymous divergence to carry out a phylogenomic analysis of WGD across a diverse set of 37 diatom species. Key Results Several methods identified WGDs of varying age across diatoms. Determining the occurrence, exact number, and placement of events was greatly impacted by uncertainty in gene trees. WGDs inferred from synonymous divergence of paralogs varied depending on how redundancy in transcriptomes was assessed, gene families were assembled, and synonymous distances (Ks) were calculated. Our results highlighted a need for systematic evaluation of key methodological aspects of Ks‐based approaches to WGD inference. Gene tree reconciliations supported allopolyploidy as the predominant mode of polyploid formation, with strong evidence for ancient allopolyploid events in the thalassiosiroid and pennate diatom clades. Conclusions Our results suggest that WGD has played a major role in the evolution of diatom genomes. We outline challenges in reconstructing paleopolyploid events in diatoms that, together with these results, offer a framework for understanding the impact of genome duplication in a group that likely harbors substantial genomic diversity.
description: Transcriptome assemblies (DNA and corresponding amino acid sequences) used in genome duplication analyses.
DOI: 10.6084/m9.figshare.13170233
title: R0169_20170523a_videos

description: Rat 0169, skilled reaching data collected in Leventhal laboratory by Alexandra Bova
DOI: 10.15784/601397
title: Granulometry of Joinville and Livingston Island beaches
DOI: 10.17632/mghwfnwfrv.3
title: Data for: Oral uptake and persistence of the FnAb-8 protein characterized by in situ radio-labeling and PET/CT imaging

description: PET tracer labeling and imaging of protein uptake and distribution
DOI: 10.5517/ccdc.csd.cc25jh7g
title: CCDC 2011845: Experimental Crystal Structure Determination

description: Related Article: Qiang-Qiang Shi, Xing-Jie Zhang, Ting-Ting Wang, Qi Wang, Tian-Tian Sun, Muhammad Amin, Rui-Han Zhang, Xiao-Li Li, Wei-Lie Xiao|2020|Org.Lett.|22|7820|doi:10.1021/acs.orglett.0c02676
DOI: 10.5517/ccdc.csd.cc25kp9r
title: CCDC 2012994: Experimental Crystal Structure Determination

description: Related Article: Agnieszka Nowak-Król, Beata Koszarna, Maciej Krzeszewski, Trevor D. Lohrey, John Arnold, Daniel T. Gryko|2020|Org.Lett.|22|8139|doi:10.1021/acs.orglett.0c03133
DOI: 10.5517/ccdc.csd.cc25nm6p
title: CCDC 2015812: Experimental Crystal Structure Determination

description: Related Article: Xue Li, Shaoyu Mai, Xin Li, Jian Xu, Hetao Xu, Qiuling Song|2020|Org.Lett.|22|7874|doi:10.1021/acs.orglett.0c02778
DOI: 10.5517/ccdc.csd.cc25p88f
title: CCDC 2016434: Experimental Crystal Structure Determination

description: Related Article: Xue Tang, Nan Zhang, Gu He, Cheng-Hao Li, Wei Huang, Xiao-Yun Wang, Gu Zhan, Bo Han|2020|Org.Lett.|22|7909|doi:10.1021/acs.orglett.0c02836
DOI: 10.5517/ccdc.csd.cc25pflx
title: CCDC 2016599: Experimental Crystal Structure Determination

description: Related Article: Yong Chen, Hai-Lun Wan, Yuan Huang, Song Liu, Feiyi Wang, Cuifen Lu, Junqi Nie, Zuxing Chen, Guichun Yang, Chao Ma|2020|Org.Lett.|22|7797|doi:10.1021/acs.orglett.0c02600
DOI: 10.5517/ccdc.csd.cc25xll9
title: CCDC 2023481: Experimental Crystal Structure Determination

description: Related Article: Alexa Torelli, Andrew Whyte, Iuliia Polishchuk, Jonathan Bajohr, Mark Lautens|2020|Org.Lett.|22|7915|doi:10.1021/acs.orglett.0c02837
DOI: 10.5517/ccdc.csd.cc25xlmb
title: CCDC 2023482: Experimental Crystal Structure Determination

description: Related Article: Alexa Torelli, Andrew Whyte, Iuliia Polishchuk, Jonathan Bajohr, Mark Lautens|2020|Org.Lett.|22|7915|doi:10.1021/acs.orglett.0c02837
DOI: 10.5517/ccdc.csd.cc25zhzn
title: CCDC 2025322: Experimental Crystal Structure Determination

description: Related Article: Xavier Abel-Snape, Andrew Whyte, Mark Lautens|2020|Org.Lett.|22|7920|doi:10.1021/acs.orglett.0c02850
DOI: 10.5517/ccdc.csd.cc261s24
title: CCDC 2027495: Experimental Crystal Structure Determination

description: Related Article: Guo-Li Chai, Yan Qiao, Ping Zhang, Rong Guo, Juan Wang, Junbiao Chang|2020|Org.Lett.|22|8023|doi:10.1021/acs.orglett.0c02978
DOI: 10.5517/ccdc.csd.cc2620my
title: CCDC 2027729: Experimental Crystal Structure Determination

description: Related Article: Angélina Torres Ruiz, Manon H. E. Bousquet, Simon Pascal, Gabriel Canard, Valérie Mazan, Mourad Elhabiri, Denis Jacquemin, Olivier Siri|2020|Org.Lett.|22|7997|doi:10.1021/acs.orglett.0c02926
DOI: 10.21227/jhyp-hf62
title: Test submission 7

description: Fixed error with input dataframe preparation. Used clustering and prophet.
DOI: 10.6084/m9.figshare.13129529
title: Natural regeneration in urban forests is limited by early-establishment dynamics: implications for management

description: Data comparing urban and rural forest in NYC metro region. Data include forest strata (canopy, sapling, seedling, seed rain, and seed bank), stocking, and advance regeneration. Data was collected from 2016 to 2018.<br>
DOI: 10.5517/ccdc.csd.cc261vkp
title: CCDC 2027572: Experimental Crystal Structure Determination

description: Related Article: S. Dallasta Pedroso, I. Caracelli, J. Zukerman-Schpector, M. Soto-Monsalve, R.H. De Almeida Santos, C.R.D. Correia, A.L. Llanes Garcia, E.R.T. Tiekink|2020|IUCrData|5|x201228|doi:10.1107/S2414314620012286
DOI: 10.5517/ccdc.csd.cc26gmz9
title: CCDC 2039861: Experimental Crystal Structure Determination

description: Related Article: R.A. Adrian, D.R. Hernandez, H.D. Arman|2020|IUCrData|5|x201407|doi:10.1107/S2414314620014078
DOI: 10.6084/m9.figshare.13170233.v1
title: R0169_20170523a_videos

description: Rat 0169, skilled reaching data collected in Leventhal laboratory by Alexandra Bova
DOI: 10.21227/bvjh-5b02
title: LSTM for predicting energy consumption

description: The problem of predict energy consumption is an important problem for power utilities. Long-Short Term Memory have been used to predict time series. Then LSTM is used to predict energy consumption in this competition.
DOI: 10.6084/m9.figshare.13171805
title: R0169_20170525a_videos

description: Rat 0169, skilled reaching data collected in Leventhal laboratory by Alexandra Bova
DOI: 10.6084/m9.figshare.13172012
title: methylation

description: methylation
DOI: 10.6084/m9.figshare.13172012.v1
title: methylation

description: methylation
DOI: 10.6084/m9.figshare.13171463.v1
title: R0169_20170524a_videos

description: Rat 0169, skilled reaching data collected in Leventhal laboratory by Alexandra Bova
DOI: 10.6084/m9.figshare.13171463
title: R0169_20170524a_videos

description: Rat 0169, skilled reaching data collected in Leventhal laboratory by Alexandra Bova
DOI: 10.25934/00006155
title: A Phase 3, Randomised, Open-label, Crossover Study to Compare HFA vs CFC pMDI Formulations of Budesonide on Methacholine Hyper-reactivity in Patients With Stable, Persistent, Mild to Moderate Asthma

description: Vivli is an independent, non-profit organization that has developed a global data-sharing and analytics platform to serve all elements of the international research community. Our mission is to promote, coordinate, and facilitate scientific sharing and reuse of clinical research data through the creation and implementation of a sustainable global data-sharing enterprise. The Vivli platform includes an independent data repository, in-depth search engine and a cloud-based, secure analytics platform.
DOI: 10.25934/00006157
title: A Study to Evaluate the Feasibility of a Treatment Algorithm in Newly Diagnosed Asthmatic Children. An Open Follow-up to Asthma Prevention in Infants/Young Children (PAC)

description: Vivli is an independent, non-profit organization that has developed a global data-sharing and analytics platform to serve all elements of the international research community. Our mission is to promote, coordinate, and facilitate scientific sharing and reuse of clinical research data through the creation and implementation of a sustainable global data-sharing enterprise. The Vivli platform includes an independent data repository, in-depth search engine and a cloud-based, secure analytics platform.
DOI: 10.25934/00006185
title: An Open Single Centre Study to Assess the Concentration of Budesonide in Breast Milk From Asthmatic Women on Maintenance Treatment w/Pulmicort ® Turbuhaler ® at the Dose Levels 200/400 µg Bid

description: Vivli is an independent, non-profit organization that has developed a global data-sharing and analytics platform to serve all elements of the international research community. Our mission is to promote, coordinate, and facilitate scientific sharing and reuse of clinical research data through the creation and implementation of a sustainable global data-sharing enterprise. The Vivli platform includes an independent data repository, in-depth search engine and a cloud-based, secure analytics platform.
DOI: 10.25934/00006189
title: A Confirmatory Study of APTA-2217 in Adult Patients With Bronchial Asthma (A Placebo-controlled Double-blind Comparative Study)

description: Vivli is an independent, non-profit organization that has developed a global data-sharing and analytics platform to serve all elements of the international research community. Our mission is to promote, coordinate, and facilitate scientific sharing and reuse of clinical research data through the creation and implementation of a sustainable global data-sharing enterprise. The Vivli platform includes an independent data repository, in-depth search engine and a cloud-based, secure analytics platform.
DOI: 10.25934/00006198
title: A Double Blind, Double Dummy, Randomised, Multicentre Study to Compare the Efficacy and Safety of Fulvestrant 250mg With Arimidex 1mg as a Secondary-line Therapy in the Postmenopausal Women With Oestrogen Receptor Positive Advanced Breast Cancer

description: Vivli is an independent, non-profit organization that has developed a global data-sharing and analytics platform to serve all elements of the international research community. Our mission is to promote, coordinate, and facilitate scientific sharing and reuse of clinical research data through the creation and implementation of a sustainable global data-sharing enterprise. The Vivli platform includes an independent data repository, in-depth search engine and a cloud-based, secure analytics platform.
DOI: 10.25934/00006200
title: A Randomised Phase II Study Comparing Anastrozole and Fulvestrant to Anastrozole for Adjuvant Treatment of Postmenopausal Patients With Early Breast Cancer and Disseminated Tumour Cells in Bone Marrow

description: Vivli is an independent, non-profit organization that has developed a global data-sharing and analytics platform to serve all elements of the international research community. Our mission is to promote, coordinate, and facilitate scientific sharing and reuse of clinical research data through the creation and implementation of a sustainable global data-sharing enterprise. The Vivli platform includes an independent data repository, in-depth search engine and a cloud-based, secure analytics platform.
DOI: 10.25934/00006215
title: A Phase II Open Label, Multicentre, Single Arm Study to Characterise the Efficacy, Safety and Tolerability of Gefitinib 250 mg (IRESSA) as 3rd Line Treatment Re-challenge in Patients, Who Have Epidermal Growth Factor Receptor (EGFR) Mutation Positive Locally Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC) and Who Responded to Gefitinib in 1st Line and Progressed After 2nd Line Chemotherapy

description: Vivli is an independent, non-profit organization that has developed a global data-sharing and analytics platform to serve all elements of the international research community. Our mission is to promote, coordinate, and facilitate scientific sharing and reuse of clinical research data through the creation and implementation of a sustainable global data-sharing enterprise. The Vivli platform includes an independent data repository, in-depth search engine and a cloud-based, secure analytics platform.
DOI: 10.25934/00006223
title: A Phase 1 Study to Evaluate the Safety and Tolerability of MEDI4736 as Monotherapy or in Combination With Tremelimumab With or Without Azacitidine in Subjects With Myelodysplastic Syndrome After Treatment With Hypomethylating Agents

description: Vivli is an independent, non-profit organization that has developed a global data-sharing and analytics platform to serve all elements of the international research community. Our mission is to promote, coordinate, and facilitate scientific sharing and reuse of clinical research data through the creation and implementation of a sustainable global data-sharing enterprise. The Vivli platform includes an independent data repository, in-depth search engine and a cloud-based, secure analytics platform.
DOI: 10.25934/00006237
title: A Phase 1b Study to Evaluate the Safety and Efficacy of MEDI4736 as Monotherapy and in Combination With Tremelimumab or AZD9150 in Subjects With Relapsed or Refractory Diffuse Large B-cell Lymphoma.

description: Vivli is an independent, non-profit organization that has developed a global data-sharing and analytics platform to serve all elements of the international research community. Our mission is to promote, coordinate, and facilitate scientific sharing and reuse of clinical research data through the creation and implementation of a sustainable global data-sharing enterprise. The Vivli platform includes an independent data repository, in-depth search engine and a cloud-based, secure analytics platform.
DOI: 10.25934/00006244
title: A Two Part Bioequivalence Study to Compare Two Fixed Dose Combination (FDC) Tablets of Dapagliflozin/Metformin XR 5/500 mg (Part 1) and 10/1000 mg (Part 2) Manufactured at Two Different Plants (Humacao, Puerto Rico and Mount Vernon, US) in Healthy Subjects Under Fasting and Fed Conditions

description: Vivli is an independent, non-profit organization that has developed a global data-sharing and analytics platform to serve all elements of the international research community. Our mission is to promote, coordinate, and facilitate scientific sharing and reuse of clinical research data through the creation and implementation of a sustainable global data-sharing enterprise. The Vivli platform includes an independent data repository, in-depth search engine and a cloud-based, secure analytics platform.
DOI: 10.25934/00006253
title: Systemic availability of budesonide inhaled as a suspension aerosol from a metered dose inhaler with a spacer Nebuhaler attached.

description: Vivli is an independent, non-profit organization that has developed a global data-sharing and analytics platform to serve all elements of the international research community. Our mission is to promote, coordinate, and facilitate scientific sharing and reuse of clinical research data through the creation and implementation of a sustainable global data-sharing enterprise. The Vivli platform includes an independent data repository, in-depth search engine and a cloud-based, secure analytics platform.
DOI: 10.25934/00006257
title: Efficacy of budesonide suspension for nebulization in moderate to severe asthmatic infants.

description: Vivli is an independent, non-profit organization that has developed a global data-sharing and analytics platform to serve all elements of the international research community. Our mission is to promote, coordinate, and facilitate scientific sharing and reuse of clinical research data through the creation and implementation of a sustainable global data-sharing enterprise. The Vivli platform includes an independent data repository, in-depth search engine and a cloud-based, secure analytics platform.
DOI: 10.25934/00006258
title: Long-term study of budesonide suspension for nebulization in moderate to severe asthmatic infants

description: Vivli is an independent, non-profit organization that has developed a global data-sharing and analytics platform to serve all elements of the international research community. Our mission is to promote, coordinate, and facilitate scientific sharing and reuse of clinical research data through the creation and implementation of a sustainable global data-sharing enterprise. The Vivli platform includes an independent data repository, in-depth search engine and a cloud-based, secure analytics platform.
DOI: 10.25934/00006260
title: A comparison of nebulized and oral glucocorticosteroids in acute bronchial obstructivity

description: Vivli is an independent, non-profit organization that has developed a global data-sharing and analytics platform to serve all elements of the international research community. Our mission is to promote, coordinate, and facilitate scientific sharing and reuse of clinical research data through the creation and implementation of a sustainable global data-sharing enterprise. The Vivli platform includes an independent data repository, in-depth search engine and a cloud-based, secure analytics platform.
DOI: 10.25934/00006261
title: Inhaled Steroid Treatment Reduction in Stable asthmatics with Turbohaler

description: Vivli is an independent, non-profit organization that has developed a global data-sharing and analytics platform to serve all elements of the international research community. Our mission is to promote, coordinate, and facilitate scientific sharing and reuse of clinical research data through the creation and implementation of a sustainable global data-sharing enterprise. The Vivli platform includes an independent data repository, in-depth search engine and a cloud-based, secure analytics platform.
DOI: 10.25934/00006262
title: Double-blind clinical trial on the effect of budesonide in the treatment of oral aphtae

description: Vivli is an independent, non-profit organization that has developed a global data-sharing and analytics platform to serve all elements of the international research community. Our mission is to promote, coordinate, and facilitate scientific sharing and reuse of clinical research data through the creation and implementation of a sustainable global data-sharing enterprise. The Vivli platform includes an independent data repository, in-depth search engine and a cloud-based, secure analytics platform.
DOI: 10.25934/00006263
title: A placebo controlled study of inhaled budesonide in patients with steroid responsive chronic bronchitis

description: Vivli is an independent, non-profit organization that has developed a global data-sharing and analytics platform to serve all elements of the international research community. Our mission is to promote, coordinate, and facilitate scientific sharing and reuse of clinical research data through the creation and implementation of a sustainable global data-sharing enterprise. The Vivli platform includes an independent data repository, in-depth search engine and a cloud-based, secure analytics platform.
DOI: 10.25934/00006264
title: A comparison of the efficacy and acceptability of Pulmicort Turbohaler and Becotide Rotahaler

description: Vivli is an independent, non-profit organization that has developed a global data-sharing and analytics platform to serve all elements of the international research community. Our mission is to promote, coordinate, and facilitate scientific sharing and reuse of clinical research data through the creation and implementation of a sustainable global data-sharing enterprise. The Vivli platform includes an independent data repository, in-depth search engine and a cloud-based, secure analytics platform.
DOI: 10.25934/00006270
title: Early treatment of mild asthma exacerbation with inhaled budesonide: a randomized double-blind placebo controlled trial.

description: Vivli is an independent, non-profit organization that has developed a global data-sharing and analytics platform to serve all elements of the international research community. Our mission is to promote, coordinate, and facilitate scientific sharing and reuse of clinical research data through the creation and implementation of a sustainable global data-sharing enterprise. The Vivli platform includes an independent data repository, in-depth search engine and a cloud-based, secure analytics platform.
DOI: 10.25934/00006272
title: Asthmatic hyperreactivity to Metered Dose Inhalers (MDI)

description: Vivli is an independent, non-profit organization that has developed a global data-sharing and analytics platform to serve all elements of the international research community. Our mission is to promote, coordinate, and facilitate scientific sharing and reuse of clinical research data through the creation and implementation of a sustainable global data-sharing enterprise. The Vivli platform includes an independent data repository, in-depth search engine and a cloud-based, secure analytics platform.
DOI: 10.25934/00006274
title: The effect of long term exposition to pressurized MDI propellants in asthma

description: Vivli is an independent, non-profit organization that has developed a global data-sharing and analytics platform to serve all elements of the international research community. Our mission is to promote, coordinate, and facilitate scientific sharing and reuse of clinical research data through the creation and implementation of a sustainable global data-sharing enterprise. The Vivli platform includes an independent data repository, in-depth search engine and a cloud-based, secure analytics platform.