cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.22982164
title: Clinical management and diagnosis of CLN2 disease: consensus of the Brazilian experts group

description: Abstract Neuronal ceroid lipofuscinosis type 2 (CLN2) is a rare neurodegenerative genetic disease that affects children in early life. Its classic form is rapidly progressive, leading to death within the first 10 years. The urge for earlier diagnosis increases with the availability of enzyme replacement therapy. A panel of nine Brazilian child neurologists combined their expertise in CLN2 with evidence from the medical literature to establish a consensus to manage this disease in Brazil. They voted 92 questions including diagnosis, clinical manifestations, and treatment of the disease, considering the access to healthcare in this country. Clinicians should suspect CLN2 disease in any child, from 2 to 4 years old, with language delay and epilepsy. Even though the classic form is the most prevalent, atypical cases with different phenotypes can be found. Electroencephalogram, magnetic resonance imaging, molecular and biochemical testing are the main tools to investigateand confirm the diagnosis. However, we have limited access to molecular testing in Brazil, and rely on the support from the pharmaceutical industry. The management of CLN2 should involve a multidisciplinary team and focus on the quality of life of patients and on family support. Enzyme replacement therapy with Cerliponase α is an innovative treatment approved in Brazil since 2018; it delays functional decline and provides quality of life. Given the difficulties for the diagnosis and treatment of rare diseases in our public health system, the early diagnosis of CLN2 needs improvement as enzyme replacement therapy is available and modifies the prognosis of patients.
DOI: 10.6084/m9.figshare.22982164.v1
title: Clinical management and diagnosis of CLN2 disease: consensus of the Brazilian experts group

description: Abstract Neuronal ceroid lipofuscinosis type 2 (CLN2) is a rare neurodegenerative genetic disease that affects children in early life. Its classic form is rapidly progressive, leading to death within the first 10 years. The urge for earlier diagnosis increases with the availability of enzyme replacement therapy. A panel of nine Brazilian child neurologists combined their expertise in CLN2 with evidence from the medical literature to establish a consensus to manage this disease in Brazil. They voted 92 questions including diagnosis, clinical manifestations, and treatment of the disease, considering the access to healthcare in this country. Clinicians should suspect CLN2 disease in any child, from 2 to 4 years old, with language delay and epilepsy. Even though the classic form is the most prevalent, atypical cases with different phenotypes can be found. Electroencephalogram, magnetic resonance imaging, molecular and biochemical testing are the main tools to investigateand confirm the diagnosis. However, we have limited access to molecular testing in Brazil, and rely on the support from the pharmaceutical industry. The management of CLN2 should involve a multidisciplinary team and focus on the quality of life of patients and on family support. Enzyme replacement therapy with Cerliponase α is an innovative treatment approved in Brazil since 2018; it delays functional decline and provides quality of life. Given the difficulties for the diagnosis and treatment of rare diseases in our public health system, the early diagnosis of CLN2 needs improvement as enzyme replacement therapy is available and modifies the prognosis of patients.
DOI: 10.6084/m9.figshare.22308751
title: THE RELATIONSHIP BETWEEN COMPETENCE, AUTONOMY, AND RELATEDNESS SATISFACTION AND DISINTEREST IN PHYSICAL EDUCATION CLASSES IN ELEMENTARY SCHOOL

description: ABSTRACT: This study shows causes for the lack of interest of sixth and ninth-grade students in physical education classes based on the satisfaction of Basic Psychological Needs (BPN) and by the interpretation of reasons given by students for being apart of subject classes. The sequential mixed method was used. The sample of the initial phase of quantitative characteristics (extensive) was composed of 153 students, followed by the intensive phase of qualitative nature, which had 12 students. The result shows that girls feel less attended to their BPN compared to boys, in sixth grade, with an emphasis on the competence dimension, expanding to autonomy and relatedness in the ninth grade. In line with the research objectives, this study indicates that lack of ability (competence), lack of diversification of contents beyond popular coletive sports (competence/autonomy), and lack of opportunities to participate in decision-making (autonomy) are some of the reasons that lead to students to develop disinterest in physical education classes.
DOI: 10.6084/m9.figshare.22982167
title: Psychological trauma and depression in recovered COVID-19 patients: a telecommunication based observational study

description: Abstract Introduction Coronavirus disease 2019 (COVID-19) is adversely affecting the mental health of patients infected with the virus and the psychological impact on recovered COVID-19 patients is unclear. Objectives The study aimed to assess posttraumatic stress disorder (PTSD) and depression among COVID-19 patients after recovery from the disease. Methods This cross-sectional study was conducted from November 9, 2020, to December 23, 2020. The study used a telemedicine model to enroll recovered COVID-19 patients from a database of patients provided by the health authorities. The National Stressful Events Survey PTSD Short Scale (NSESSS) for adults was used to assess PTSD symptoms and the Patient Health Questionnaire (PHQ-9) was used to assess depression. Results The study enrolled 503 recovered COVID-19 patients with a mean age of 41.90 years. The majority were asymptomatic (64.6%), while 21.5% had had moderate to severe forms of the disease. Prevalence rates of PTSD symptoms and depression were 56.9 and 29% respectively. COVID-19 patients with severe forms of the disease were significantly more affected by PTSD symptoms (vs. mild, odds ratio [OR] = 18.7, 95%confidence interval [CI] 9.9-35.5) and depression (vs. mild, OR = 19.8, 95% CI 9.9-39.5). Similarly, patients who required oxygen or ventilator support reported significantly higher rates of PTSD symptoms (vs. managed at home, OR = 17.4, 95% CI 8.3-36.4) and depression (vs. managed at home, OR = 22.0, 95% CI 10.1-47.7). Conclusion This study reports that recovered COVID-19 patients suffered from a significant amount of depression and experienced significant PTSD symptoms. It will help with addressing a major psychological concern among the recovered subjects.
DOI: 10.6084/m9.figshare.22982167.v1
title: Psychological trauma and depression in recovered COVID-19 patients: a telecommunication based observational study

description: Abstract Introduction Coronavirus disease 2019 (COVID-19) is adversely affecting the mental health of patients infected with the virus and the psychological impact on recovered COVID-19 patients is unclear. Objectives The study aimed to assess posttraumatic stress disorder (PTSD) and depression among COVID-19 patients after recovery from the disease. Methods This cross-sectional study was conducted from November 9, 2020, to December 23, 2020. The study used a telemedicine model to enroll recovered COVID-19 patients from a database of patients provided by the health authorities. The National Stressful Events Survey PTSD Short Scale (NSESSS) for adults was used to assess PTSD symptoms and the Patient Health Questionnaire (PHQ-9) was used to assess depression. Results The study enrolled 503 recovered COVID-19 patients with a mean age of 41.90 years. The majority were asymptomatic (64.6%), while 21.5% had had moderate to severe forms of the disease. Prevalence rates of PTSD symptoms and depression were 56.9 and 29% respectively. COVID-19 patients with severe forms of the disease were significantly more affected by PTSD symptoms (vs. mild, odds ratio [OR] = 18.7, 95%confidence interval [CI] 9.9-35.5) and depression (vs. mild, OR = 19.8, 95% CI 9.9-39.5). Similarly, patients who required oxygen or ventilator support reported significantly higher rates of PTSD symptoms (vs. managed at home, OR = 17.4, 95% CI 8.3-36.4) and depression (vs. managed at home, OR = 22.0, 95% CI 10.1-47.7). Conclusion This study reports that recovered COVID-19 patients suffered from a significant amount of depression and experienced significant PTSD symptoms. It will help with addressing a major psychological concern among the recovered subjects.
DOI: 10.6084/m9.figshare.22982176
title: Comparison between round multi-strand wire and rectangular wire bonded retainers: a randomized clinical trial

description: ABSTRACT Objective: The primary objective was to compare round multi-strand wire and Ortho-Flex-Tech™ rectangular wire retainers in terms of gingival health. The secondary objectives were to assess plaque/calculus accumulation, and to determine the effectiveness of these retainers in maintaining tooth alignment and their failure rate. Material and Methods: This single-center study was a two-arm parallel randomized clinical trial and was conducted at the Orthodontic clinics in Dental Teaching Center/Jordan University of Science and Technology. Sixty patients, with bonded retention for the mandibular anterior segment after fixed orthodontic treatment, were randomly selected. The sample comprised Caucasian patients with mild to moderate pretreatment crowding in the mandibular anterior region, Class I relationship, treated without extraction of mandibular anterior tooth. In addition, only patients presenting normal overjet and overbite after treatment were included. Intervention: One group received round multi-strand wire retainer (30 patients, average age: 19.7 ± 3.8 years), while the other group received Ortho-Flex-Tech™ retainer (30 patients; average age: 19.3 ± 3.2 years). In both groups, the retainers were bonded to all mandibular anterior teeth from canine to canine. All patients were recalled one year after bracket debonding. Randomization sequence was created using Excel 2010, with a 1:1 allocation, using random block size 4. The allocation sequence was concealed in sequentially numbered, opaque and sealed envelopes. Only participants were blinded to the type of bonded retainer used. The primary outcome was to compare the gingival condition between the two groups. The secondary outcomes were to assess plaque/calculus indices, irregularity index of the mandibular anterior teeth and retainers’ failure rate. Comparisons were conducted using Mann-Whitney U test or chi-square test. Statistical significance was predetermined at the p≤ 0.05 level for all tests. Results: Complete data were collected for 46 patients (round multi-strand wire retainer group, n=24 patients; rectangular Ortho-Flex-Tech™ retainer group, n=22 patients). No significant differences were found in the gingival health parameters between the two groups (p&gt;0.05). Ortho-Flex-Tech™ retainers maintained the alignment of mandibular anterior teeth more than multi-strand retainer (p&lt;0.05). No significant difference was found in the failure rate between the two groups (p&gt;0.05). Conclusions: Gingival health parameters and failure rate were not different in both groups. However, Ortho-Flex-Tech™ retainers were more efficient to retain the mandibular incisors than the multi-strand retainers; nevertheless, the difference was not clinically significant.
DOI: 10.6084/m9.figshare.22982176.v1
title: Comparison between round multi-strand wire and rectangular wire bonded retainers: a randomized clinical trial

description: ABSTRACT Objective: The primary objective was to compare round multi-strand wire and Ortho-Flex-Tech™ rectangular wire retainers in terms of gingival health. The secondary objectives were to assess plaque/calculus accumulation, and to determine the effectiveness of these retainers in maintaining tooth alignment and their failure rate. Material and Methods: This single-center study was a two-arm parallel randomized clinical trial and was conducted at the Orthodontic clinics in Dental Teaching Center/Jordan University of Science and Technology. Sixty patients, with bonded retention for the mandibular anterior segment after fixed orthodontic treatment, were randomly selected. The sample comprised Caucasian patients with mild to moderate pretreatment crowding in the mandibular anterior region, Class I relationship, treated without extraction of mandibular anterior tooth. In addition, only patients presenting normal overjet and overbite after treatment were included. Intervention: One group received round multi-strand wire retainer (30 patients, average age: 19.7 ± 3.8 years), while the other group received Ortho-Flex-Tech™ retainer (30 patients; average age: 19.3 ± 3.2 years). In both groups, the retainers were bonded to all mandibular anterior teeth from canine to canine. All patients were recalled one year after bracket debonding. Randomization sequence was created using Excel 2010, with a 1:1 allocation, using random block size 4. The allocation sequence was concealed in sequentially numbered, opaque and sealed envelopes. Only participants were blinded to the type of bonded retainer used. The primary outcome was to compare the gingival condition between the two groups. The secondary outcomes were to assess plaque/calculus indices, irregularity index of the mandibular anterior teeth and retainers’ failure rate. Comparisons were conducted using Mann-Whitney U test or chi-square test. Statistical significance was predetermined at the p≤ 0.05 level for all tests. Results: Complete data were collected for 46 patients (round multi-strand wire retainer group, n=24 patients; rectangular Ortho-Flex-Tech™ retainer group, n=22 patients). No significant differences were found in the gingival health parameters between the two groups (p&gt;0.05). Ortho-Flex-Tech™ retainers maintained the alignment of mandibular anterior teeth more than multi-strand retainer (p&lt;0.05). No significant difference was found in the failure rate between the two groups (p&gt;0.05). Conclusions: Gingival health parameters and failure rate were not different in both groups. However, Ortho-Flex-Tech™ retainers were more efficient to retain the mandibular incisors than the multi-strand retainers; nevertheless, the difference was not clinically significant.
DOI: 10.6084/m9.figshare.22982183
title: Investigating the impacts on non-Newtonian conceptions of Physics undergraduates and graduates in relation to the concepts of Force and Motion

description: Abstract: Practices that are considered traditional and poorly contribute to students’ learning persist in the teaching of Physics. Thus, this article aimed at understanding the non-Newtonian conceptions of undergraduates and graduates in a Physics Degree course in relation to the concepts of Force and Motion, in addition to analyzing possible influences on these conceptions when students were exposed to a Computational Simulation and a textbook, applied under the same conditions (freely and for a short period of time). This is a quantitative study with a quasi-experimental design, with a control group and an experimental one. In both groups, a reduced version of the Force Concept Inventory (FCI) was applied in the construction of the data, both in the pre-test and in the post-test. In addition to the analysis of conceptions, the normalized learning gain and the effect size were used. The results indicate that, on average, the proposed treatments did not significantly influence the students' conceptions.
DOI: 10.6084/m9.figshare.22982183.v1
title: Investigating the impacts on non-Newtonian conceptions of Physics undergraduates and graduates in relation to the concepts of Force and Motion

description: Abstract: Practices that are considered traditional and poorly contribute to students’ learning persist in the teaching of Physics. Thus, this article aimed at understanding the non-Newtonian conceptions of undergraduates and graduates in a Physics Degree course in relation to the concepts of Force and Motion, in addition to analyzing possible influences on these conceptions when students were exposed to a Computational Simulation and a textbook, applied under the same conditions (freely and for a short period of time). This is a quantitative study with a quasi-experimental design, with a control group and an experimental one. In both groups, a reduced version of the Force Concept Inventory (FCI) was applied in the construction of the data, both in the pre-test and in the post-test. In addition to the analysis of conceptions, the normalized learning gain and the effect size were used. The results indicate that, on average, the proposed treatments did not significantly influence the students' conceptions.
DOI: 10.6084/m9.figshare.22982186
title: Reproductive performance of hair sheep under different body conditions and feeding levels

description: Abstract The objective of this work was to evaluate the effect of the interaction between feeding level (FL) and body condition score (BCS) on the reproductive parameters of Pelibuey hair sheep (Ovis aries). The experimental units (64 ewes) were randomly assigned to one of four treatments: low feeding level and low body condition score; high feeding level and low body condition score; low feeding level and high body condition score; and high feeding level and high body condition score. The effect of sheep body condition score was significant on the pregnancy and lambing rates. The effect of feeding level was significant on the ovulation, estrus returning, pregnancy, and prolificacy rates. The interaction effect between BCS and FL was significant on the ovulation, estrus returning, pregnancy, lambing, and prolificacy rates. The reproductive function is more sensitive to the better nutrition effects in sheep with a low body condition score.
DOI: 10.6084/m9.figshare.22982186.v1
title: Reproductive performance of hair sheep under different body conditions and feeding levels

description: Abstract The objective of this work was to evaluate the effect of the interaction between feeding level (FL) and body condition score (BCS) on the reproductive parameters of Pelibuey hair sheep (Ovis aries). The experimental units (64 ewes) were randomly assigned to one of four treatments: low feeding level and low body condition score; high feeding level and low body condition score; low feeding level and high body condition score; and high feeding level and high body condition score. The effect of sheep body condition score was significant on the pregnancy and lambing rates. The effect of feeding level was significant on the ovulation, estrus returning, pregnancy, and prolificacy rates. The interaction effect between BCS and FL was significant on the ovulation, estrus returning, pregnancy, lambing, and prolificacy rates. The reproductive function is more sensitive to the better nutrition effects in sheep with a low body condition score.
DOI: 10.6084/m9.figshare.22982197.v1
title: READING AS AN INTERACTION BETWEEN THE READER AND THE TEXT: CONCEPTIONS AND PRACTICES IN THE PNAIC NOTEBOOKS

description: ABSTRACT: The article aims at presenting and discussing the conceptions and practices of reading explored in the training notebooks of the National Pact for Literacy at the Right Age (PNAIC). The analysis process of the content of the notebooks was conducted based on the following question: what conception of reading and what teaching practices are brought in the collection of notebooks of PNAIC? The discussion on the conceptions and practices of reading was carried out based on theoretical studies that see reading as a cognitive act set in the interaction between text-reader. The results of the analysis show that the texts of the training notebooks conceive the reading from elements of the interactive model of reading. Concerning the reading practices, the activities of extraction of meanings from the text for the development of textual understanding are prioritized. In the reports, there is a predominance of records of shared reading activity, in which the formulation of questions is the main strategy to help the student to find information and infer meanings. Yet the exercises that aim at activating previous knowledge of the reader or activities of reading systematization, such as essay writing, are less frequently used. Finally, we highlight the importance of analyzing theoretical and methodological assumptions of continuous training programs in order to understand how these help the teachers to analyze their practices and rethink them according to the student’s needs.
DOI: 10.6084/m9.figshare.22982197
title: READING AS AN INTERACTION BETWEEN THE READER AND THE TEXT: CONCEPTIONS AND PRACTICES IN THE PNAIC NOTEBOOKS

description: ABSTRACT: The article aims at presenting and discussing the conceptions and practices of reading explored in the training notebooks of the National Pact for Literacy at the Right Age (PNAIC). The analysis process of the content of the notebooks was conducted based on the following question: what conception of reading and what teaching practices are brought in the collection of notebooks of PNAIC? The discussion on the conceptions and practices of reading was carried out based on theoretical studies that see reading as a cognitive act set in the interaction between text-reader. The results of the analysis show that the texts of the training notebooks conceive the reading from elements of the interactive model of reading. Concerning the reading practices, the activities of extraction of meanings from the text for the development of textual understanding are prioritized. In the reports, there is a predominance of records of shared reading activity, in which the formulation of questions is the main strategy to help the student to find information and infer meanings. Yet the exercises that aim at activating previous knowledge of the reader or activities of reading systematization, such as essay writing, are less frequently used. Finally, we highlight the importance of analyzing theoretical and methodological assumptions of continuous training programs in order to understand how these help the teachers to analyze their practices and rethink them according to the student’s needs.