cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.1290211
title: Above the Pale Blue Dot: Awe and Humility in Immersive Virtual Environments -- Supplemental Documents

description: Seeing Earth from space, astronauts frequently report awe—an emotion entailing vastness and cognitive accommodation—as well as “feeling small,” a description that evokes humility. To discover the conditions under which an awe-inspiring experience might lead to humility, we simulated a prototypical awe experience in immersive virtual environments (IVE). Nine-five participants were randomly assigned either to 1) view Earth zooming away (as if aboard a spaceship) while hearing selections from Carl Sagan’s Pale Blue Dot or 2) observe models of Earth and Pluto while hearing space-related facts. Relative to controls, those who viewed the Pale Blue Dot experienced greater awe (r = .41) and humble feelings (r = .21), changes that were partially mediated by feelings of connection to others and thoughts about oneself. However, other-connectedness only increased humility in people with high self-esteem, and self-relevant thoughts only increased humility in those who experienced awe. Our results show that awe and humility are positive experiences, conceptually related by common mediators (other-connectedness and self-relevant thoughts) with a pathway from awe to humility dependent on the self-relevance of the awe experience. Our research validates a novel humility- and awe-enhancing intervention and highlights the utility of IVE technology in psychological research.
DOI: 10.6084/m9.figshare.1290211.v1
title: Above the Pale Blue Dot: Awe and Humility in Immersive Virtual Environments -- Supplemental Documents

description: Seeing Earth from space, astronauts frequently report awe—an emotion entailing vastness and cognitive accommodation—as well as “feeling small,” a description that evokes humility. To discover the conditions under which an awe-inspiring experience might lead to humility, we simulated a prototypical awe experience in immersive virtual environments (IVE). Nine-five participants were randomly assigned either to 1) view Earth zooming away (as if aboard a spaceship) while hearing selections from Carl Sagan’s Pale Blue Dot or 2) observe models of Earth and Pluto while hearing space-related facts. Relative to controls, those who viewed the Pale Blue Dot experienced greater awe (r = .41) and humble feelings (r = .21), changes that were partially mediated by feelings of connection to others and thoughts about oneself. However, other-connectedness only increased humility in people with high self-esteem, and self-relevant thoughts only increased humility in those who experienced awe. Our results show that awe and humility are positive experiences, conceptually related by common mediators (other-connectedness and self-relevant thoughts) with a pathway from awe to humility dependent on the self-relevance of the awe experience. Our research validates a novel humility- and awe-enhancing intervention and highlights the utility of IVE technology in psychological research.
DOI: 10.6084/m9.figshare.1290327.v1
title: Default Mode Network, Motor Network, Dorsal and Ventral Basal Ganglia Networks in the Rat Brain: Comparison to Human Networks Using Resting State-fMRI: The Human Data

description: See the paper in PLOS1
DOI: 10.6084/m9.figshare.1290327.v2
title: Default Mode Network, Motor Network, Dorsal and Ventral Basal Ganglia Networks in the Rat Brain: Comparison to Human Networks Using Resting State-fMRI: The Human Data

description: See the paper in PLOS1
DOI: 10.6084/m9.figshare.1289920
title: Acervo fotográfico de paisagens e vegetações do estado do Ceará

description: Esse é um acervo fotográfico das diferentes vegetações e paisagens que ocorrem no estado do Ceará, nordeste do Brasil. Ele é um complemento visual aos tipos vegetacionais do estado conforme discutidos no artigo Moro et al. 2015. Rodriguésia.
DOI: 10.6084/m9.figshare.1289921
title: README document of PhenotypeLinks project

description: Document explaining content of PhenotypeLinks project developed for PhD thesis "Bioinformatics Tools for the Analysis of Gene-Phenotype Relationships Coupled with a Next Generation ChIP-Sequencing Data Processing Pipeline". Supporting software moved to github.com/erinijapranckeviciene<br>
DOI: 10.6084/m9.figshare.1289930
title: Vegetação, unidades fitoecológicas e diversidade paisagística do estado do Ceará

description: Os arquivos aqui disponíveis são suplementos digitais ao artigo "Vegetação, unidades fitoecológicas e diversidade paisagística do estado do Ceará", publicado na revista Rodriguésia, volume 66(3) 1- O primeiro arquivo é o mapa geomorfológico do estado do Ceará apresentado no artigo. 2- O segundo é o mapa de unidades fitoecológicas do Ceará apresentado e discutido em nosso artigo, o qual é uma modificação da proposta cartográfica feita por Figueiredo (1997. Atlas do Ceará. Fortaleza: IPLANCE). 3- Os arquivos 3.1, 3.2 e 3.3 são arquivos para visualizar o mapa fitogeográfico do artigo em sistemas de informações geográficas. O arquivo 3.1 é o mapa apresentado em nosso artigo em formato KML, para baixar e visualizar no Google Earth. O arquivo 3.2. é o mesmo mapa em formato Shapefile para que o leitor possa fazer seus próprios mapas à partir do mapa apresentado no artigo. O arquivo 3.3 é o mapa de unidades fitoecológicas do Ceará como originalmente proposto pelo IPECE no Atlas do Ceará, em formato KML para visualizar no Google Earth. 4- O quarto arquivo é um organograma representando a relação entre as diferentes unidades geomorfológicas e os tipos vegetacionais do estado. 5- O quinto arquivo traz uma listagem de espécies características de cada tipo vegetacional tratado no artigo. Esta lista não é extensiva e apenas mostra um pequeno grupo de espécies típicas das vegetações cearenses. 6 e 7- Por fim, nosso artigo analiza por meio de análises multivariadas a similaridade florística entre as vegetações do estado, segundo dados disponíveis na literatura. A matriz de presença-ausência utilizada nas análises multivariadas e as referências bibliográficas dos trabalhos estão respectivamente no sexto e sétimo arquivos. Também disponibilizamos como suplemento digital ao artigo um acervo fotográfico dos diferentes tipos vegetacionais e paisagens do estado do Ceará. O acervo fotográfico pode ser acessado em: http://dx.doi.org/10.6084/m9.figshare.1289920. M.M. Moura-Fé foi responsável pela alaboração do arquivo 1; M.F. Moro foi responsável pela alaboração dos arquivos 2 e 3; M.B. Macêdo foi responsável pelo arquivo 4; A.S.F. Castro foi responsável pelo arquivo 5 e R.C. Costa foi responsável pelos arquivos 6 e 7.
DOI: 10.6084/m9.figshare.1290327.v3
title: Default Mode Network, Motor Network, Dorsal and Ventral Basal Ganglia Networks in the Rat Brain: Comparison to Human Networks Using Resting State-fMRI: The Raw Data

description: See the paper in PLOS1
DOI: 10.6084/m9.figshare.1290327.v4
title: Default Mode Network, Motor Network, Dorsal and Ventral Basal Ganglia Networks in the Rat Brain: Comparison to Human Networks Using Resting State-fMRI: The Raw Data

description: See the paper in PLOS1
DOI: 10.6084/m9.figshare.1289881
title: Test for recall rates of VExtractor and SemanticVExtractor algorithms as compared to the gold standard

description: Recall rates for VExtractor and SemanticVExtractor, where the gold standard was the Manually Curated Venoms table.
DOI: 10.6084/m9.figshare.1289918
title: Analyzing B-vitamins in Human Milk: Methodological Approaches

description: According to the World Health Organization (WHO), infants should be exclusively breastfed for the first six months of life. However, there is insufficient information about the concentration of nutrients in human milk. For some nutrients, including B-vitamins, maternal intake affects their concentration in human milk but the extent to which inadequate maternal diets affect milk B-vitamin content is poorly documented. Little is known about infant requirements for B-vitamins; recommendations are generally set as Adequate Intakes (AI) calculated on the basis of the mean volume of milk (0.78 L/day) consumed by infants exclusively fed with human milk from well-nourished mothers during the first six months, and the concentration of each vitamin in milk based on reported values. Methods used for analyzing B-vitamins, commonly microbiological, radioisotope dilution or more recently chromatographic, coupled with UV, fluorometric and MS detection, have rarely been validated for the complex human milk matrix. Thus the validity, accuracy, and sensitivity of analytical methods is important for understanding infant requirements for these nutrients, the maternal intakes needed to support adequate concentrations in breast milk. This review summarizes current knowledge on methods used for analyzing the B-vitamins thiamin, riboflavin, niacin, vitamin B-6 and pantothenic acid, vitamin B-12, folate, biotin, and choline in human milk, their chemical and physical properties, the different forms and changes in concentration during lactation, and the effects of deficiency on the infant.
DOI: 10.6084/m9.figshare.1289918.v2
title: Analyzing B-vitamins in Human Milk: Methodological Approaches

description: According to the World Health Organization (WHO), infants should be exclusively breastfed for the first six months of life. However, there is insufficient information about the concentration of nutrients in human milk. For some nutrients, including B-vitamins, maternal intake affects their concentration in human milk but the extent to which inadequate maternal diets affect milk B-vitamin content is poorly documented. Little is known about infant requirements for B-vitamins; recommendations are generally set as Adequate Intakes (AI) calculated on the basis of the mean volume of milk (0.78 L/day) consumed by infants exclusively fed with human milk from well-nourished mothers during the first six months, and the concentration of each vitamin in milk based on reported values. Methods used for analyzing B-vitamins, commonly microbiological, radioisotope dilution or more recently chromatographic, coupled with UV, fluorometric and MS detection, have rarely been validated for the complex human milk matrix. Thus the validity, accuracy, and sensitivity of analytical methods is important for understanding infant requirements for these nutrients, the maternal intakes needed to support adequate concentrations in breast milk. This review summarizes current knowledge on methods used for analyzing the B-vitamins thiamin, riboflavin, niacin, vitamin B-6 and pantothenic acid, vitamin B-12, folate, biotin, and choline in human milk, their chemical and physical properties, the different forms and changes in concentration during lactation, and the effects of deficiency on the infant.
DOI: 10.6084/m9.figshare.1289918.v1
title: Analyzing B-Vitamins in Human Milk: Methodological Approaches

description: ABSTRACTAccording to the World Health Organization (WHO) infants should be exclusively breastfed for the first six months of life. However, there is insufficient information about the concentration of nutrients in human milk. For some nutrients, including B-vitamins, maternal intake affects their concentration in human milk but the extent to which inadequate maternal diets affect milk B-vitamin content is poorly documented. Little is known about infant requirements for B-vitamins; recommendations are generally set as Adequate Intakes (AI) calculated based on the mean volume of milk (0.78L/day) consumed by infants exclusively fed with human milk from well-nourished mothers during the first six months, and the concentration of each vitamin in milk based on reported values. Methods used for analyzing B-vitamins, commonly microbiological, radioisotope dilution or more recently chromatographic, coupled with UV, fluorometric and MS detection, have rarely been validated for the complex human milk matrix. Thus the validity, accuracy and sensitivity of analytical methods is important for understanding infant requirements for these nutrients, the maternal intakes needed to support adequate concentrations in breast milk. This review summarizes current knowledge on methods used for analyzing the B-vitamins thiamin, riboflavin, niacin, vitamin B-6 and pantothenic acid, vitamin B-12, folate, biotin, and choline in human milk, their chemical and physical properties, the different forms and changes in concentration during lactation, and the effects of deficiency on the infant.
DOI: 10.6084/m9.figshare.1290327.v5
title: Default Mode Network, Motor Network, Dorsal and Ventral Basal Ganglia Networks in the Rat Brain: Comparison to Human Networks Using Resting State-fMRI: The Raw Data

description: See the paper in PLOS1
DOI: 10.6084/m9.figshare.1289881.v2
title: Test for recall rates of VExtractor and SemanticVExtractor algorithms as compared to the gold standard

description: Recall rates for VExtractor and SemanticVExtractor, where the gold standard was the Manually Curated Venoms table.
DOI: 10.6084/m9.figshare.1289881.v1
title: VenomKB_Recall

description: Recall rates for VExtractor and SemanticVExtractor, where the gold standard was the Manually Curated Venoms table.
DOI: 10.6084/m9.figshare.1289867.v1
title: A phenotypic screen identifies microtubule plus end assembly regulators that can function in mitotic spindle orientation

description: Proper regulation of microtubule dynamics during mitosis is essential for faithful chromosome segregation. In fact, recently we discovered increased microtubule plus end assembly rates that are frequently observed in human cancer cells as an important mechanism leading to whole chromosome missegregation and chromosomal instability (CIN). However, the genetic alterations responsible for increased microtubule polymerization rates in cancer cells remain largely unknown. The identification of such lesions is hampered by the fact that determining dynamic parameters of microtubules usually involves analyses of living cells, which is technically difficult to perform in large-scale screening settings. Therefore, we sought to identify alternative options to systematically identify regulators of microtubule plus end polymerization. Here, we introduce a simple and robust phenotypic screening assay that is based on the analyses of monopolar mitotic spindle structures that are induced upon inhibition of the mitotic kinesin Eg5/KIF11. We show that increased microtubule polymerization causes highly asymmetric monoasters in the presence of Eg5/KIF11 inhibition and this phenotype can be reliably assessed in living as well as in fixed cells. Using this assay we performed a siRNA screen, in which we identify several microtubule plus end binding proteins as well as centrosomal and cortex associated proteins as important regulators of microtubule plus end assembly. Interestingly, we demonstrate that a subgroup of these regulators function in the regulation of spindle orientation through their role in dampening microtubule plus end polymerization.
DOI: 10.6084/m9.figshare.1290327.v6
title: Default Mode Network, Motor Network, Dorsal and Ventral Basal Ganglia Networks in the Rat Brain: Comparison to Human Networks Using Resting State-fMRI: The Raw Data

description: See the paper in PLOS1
DOI: 10.6084/m9.figshare.1289866.v1
title: Activation of autophagy via Ca<sup>2+</sup>-dependent AMPK/mTOR pathway in rat notochordal cells is a cellular adaptation under hyperosmotic stress

description: Nucleus pulposus (NP) cells experience hyperosmotic stress in spinal discs; however, how these cells can survive in the hostile microenvironment remains unclear. Autophagy has been suggested to maintain cellular homeostasis under different stresses by degrading the cytoplasmic proteins and organelles. Here, we explored whether autophagy is a cellular adaptation in rat notochordal cells under hyperosmotic stress. Hyperosmotic stress was found to activate autophagy in a dose- and time-dependent manner. SQSTM1/P62 expression was decreased as the autophagy level increased. Transient Ca<sup>2+</sup> influx from intracellular stores and extracellular space was stimulated by hyperosmotic stress. Activation of AMPK and inhibition of p70S6K were observed under hyperosmotic conditions. However, intercellular Ca<sup>2+</sup> chelation inhibited the increase of LC3-II and partly reversed the decrease of p70S6K. Hyperosmotic stress decreased cell viability and promoted apoptosis. Inhibition of autophagy led to SQSTM1/P62 accumulation, reduced cell viability, and accelerated apoptosis in notochordal cells under this condition. These evidences suggest that autophagy induction via the Ca<sup>2+</sup>-dependent AMPK/mTOR pathway might occur as an adaptation mechanism for notochordal cells under hyperosmotic stress. Thus, activating autophagy might be a promising approach to improve viability of notochordal cells in intervertebral discs.
DOI: 10.6084/m9.figshare.1289852
title: Ethical Numbers: Ethics Training in U.S. Graduate Statistics Programs, 2013–2014

description: As important members of research teams, statisticians bear an ethical responsibility to analyze, interpret, and report data honestly and objectively. One way of reinforcing ethical responsibilities is through required courses covering a variety of ethics-related topics at the graduate level. We assessed ethics requirements for graduate-level statistics training programs in the United States for the 2013–2014 academic year using the websites of 88 universities, examining 103 biostatistics programs, and 136 statistics degree programs. We categorized programs’ ethics training requirements as required or not required. Thirty-one (35.1%) universities required an ethics course for at least some degree students. Sixty-two (25.5%) degree programs required an ethics course for at least some students. The majority (77.4%) of required courses were worth 0 or 1 credit. Of the 177 programs without an ethics requirement, 19 (10.7%) listed an ethics elective. Although a single ethics course is insufficient for instilling an ethical approach to science, degree programs that model expectations through coursework point to the value of ethics in science. More training programs should prepare statisticians to consider the ethical dimensions of their work through required coursework. Supplementary materials for this article are available online.
DOI: 10.6084/m9.figshare.1289867
title: A phenotypic screen identifies microtubule plus end assembly regulators that can function in mitotic spindle orientation

description: Proper regulation of microtubule dynamics during mitosis is essential for faithful chromosome segregation. In fact, recently we discovered increased microtubule plus end assembly rates that are frequently observed in human cancer cells as an important mechanism leading to whole chromosome missegregation and chromosomal instability (CIN). However, the genetic alterations responsible for increased microtubule polymerization rates in cancer cells remain largely unknown. The identification of such lesions is hampered by the fact that determining dynamic parameters of microtubules usually involves analyses of living cells, which is technically difficult to perform in large-scale screening settings. Therefore, we sought to identify alternative options to systematically identify regulators of microtubule plus end polymerization. Here, we introduce a simple and robust phenotypic screening assay that is based on the analyses of monopolar mitotic spindle structures that are induced upon inhibition of the mitotic kinesin Eg5/KIF11. We show that increased microtubule polymerization causes highly asymmetric monoasters in the presence of Eg5/KIF11 inhibition and this phenotype can be reliably assessed in living as well as in fixed cells. Using this assay we performed a siRNA screen, in which we identify several microtubule plus end binding proteins as well as centrosomal and cortex associated proteins as important regulators of microtubule plus end assembly. Interestingly, we demonstrate that a subgroup of these regulators function in the regulation of spindle orientation through their role in dampening microtubule plus end polymerization.
DOI: 10.6084/m9.figshare.1289867.v2
title: A phenotypic screen identifies microtubule plus end assembly regulators that can function in mitotic spindle orientation

description: Proper regulation of microtubule dynamics during mitosis is essential for faithful chromosome segregation. In fact, recently we discovered increased microtubule plus end assembly rates that are frequently observed in human cancer cells as an important mechanism leading to whole chromosome missegregation and chromosomal instability (CIN). However, the genetic alterations responsible for increased microtubule polymerization rates in cancer cells remain largely unknown. The identification of such lesions is hampered by the fact that determining dynamic parameters of microtubules usually involves analyses of living cells, which is technically difficult to perform in large-scale screening settings. Therefore, we sought to identify alternative options to systematically identify regulators of microtubule plus end polymerization. Here, we introduce a simple and robust phenotypic screening assay that is based on the analyses of monopolar mitotic spindle structures that are induced upon inhibition of the mitotic kinesin Eg5/KIF11. We show that increased microtubule polymerization causes highly asymmetric monoasters in the presence of Eg5/KIF11 inhibition and this phenotype can be reliably assessed in living as well as in fixed cells. Using this assay we performed a siRNA screen, in which we identify several microtubule plus end binding proteins as well as centrosomal and cortex associated proteins as important regulators of microtubule plus end assembly. Interestingly, we demonstrate that a subgroup of these regulators function in the regulation of spindle orientation through their role in dampening microtubule plus end polymerization.
DOI: 10.6084/m9.figshare.1289867.v4
title: A phenotypic screen identifies microtubule plus end assembly regulators that can function in mitotic spindle orientation

description: Proper regulation of microtubule dynamics during mitosis is essential for faithful chromosome segregation. In fact, recently we discovered increased microtubule plus end assembly rates that are frequently observed in human cancer cells as an important mechanism leading to whole chromosome missegregation and chromosomal instability (CIN). However, the genetic alterations responsible for increased microtubule polymerization rates in cancer cells remain largely unknown. The identification of such lesions is hampered by the fact that determining dynamic parameters of microtubules usually involves analyses of living cells, which is technically difficult to perform in large-scale screening settings. Therefore, we sought to identify alternative options to systematically identify regulators of microtubule plus end polymerization. Here, we introduce a simple and robust phenotypic screening assay that is based on the analyses of monopolar mitotic spindle structures that are induced upon inhibition of the mitotic kinesin Eg5/KIF11. We show that increased microtubule polymerization causes highly asymmetric monoasters in the presence of Eg5/KIF11 inhibition and this phenotype can be reliably assessed in living as well as in fixed cells. Using this assay we performed a siRNA screen, in which we identify several microtubule plus end binding proteins as well as centrosomal and cortex associated proteins as important regulators of microtubule plus end assembly. Interestingly, we demonstrate that a subgroup of these regulators function in the regulation of spindle orientation through their role in dampening microtubule plus end polymerization.