cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.16940886.v1
title: Bone mesenchymal stem cells-derived miR-223-3p-containing exosomes ameliorate lipopolysaccharide-induced acute uterine injury via interacting with endothelial progenitor cells

description: Bone mesenchymal stem cells (BMSCs) have been used for the treatment of acute uterine injury (AUI)-induced intrauterine adhesion (IUA) via interacting with the endothelial progenitor cells (EPCs), and BMSCs-derived exosomes (BMSCs-exo) may be the key regulators for this process. However, the underlying mechanisms have not been studied. Based on the existed literatures, lipopolysaccharide (LPS) was used to induce AUI in mice models and EPCs to mimic the realistic pathogenesis of IUA <i>in vivo</i> and <i>in vitro</i>. Our data suggested that LPS induced apoptotic and pyroptotic cell death in mice uterine horn tissues and EPCs, and the clinical data supported that increased levels of pro-inflammatory cytokines IL-18 and IL-1β were also observed in IUA patients’ serum samples, and silencing of NLRP3 rescued cell viability in LPS-treated EPCs. Next, the LPS-treated EPCs were respectively co-cultured with BMSCs in the Transwell system and BMSCs-exo, and the results hinted that both BMSCs and BMSCs-exo reversed the promoting effects of LPS treatment-induced cell death in EPCs. Then, we screened out miR-223-3p, as the upstream regulator for NLRP3, was enriched in BMSCs-exo, and BMSCs-exo inactivated NLRP3-mediated cell pyroptosis in EPCs via delivering miR-223-3p. Interestingly, upregulation of miR-223-3p attenuated LPS-induced cell death in EPCs. Collectively, we concluded that BMSCs-exo upregulated miR-223-3p to degrade NLRP3 in EPCs, which further reversed the cytotoxic effects of LPS treatment on EPCs to ameliorate LPS-induced AUI.
DOI: 10.6084/m9.figshare.16940886
title: Bone mesenchymal stem cells-derived miR-223-3p-containing exosomes ameliorate lipopolysaccharide-induced acute uterine injury via interacting with endothelial progenitor cells

description: Bone mesenchymal stem cells (BMSCs) have been used for the treatment of acute uterine injury (AUI)-induced intrauterine adhesion (IUA) via interacting with the endothelial progenitor cells (EPCs), and BMSCs-derived exosomes (BMSCs-exo) may be the key regulators for this process. However, the underlying mechanisms have not been studied. Based on the existed literatures, lipopolysaccharide (LPS) was used to induce AUI in mice models and EPCs to mimic the realistic pathogenesis of IUA <i>in vivo</i> and <i>in vitro</i>. Our data suggested that LPS induced apoptotic and pyroptotic cell death in mice uterine horn tissues and EPCs, and the clinical data supported that increased levels of pro-inflammatory cytokines IL-18 and IL-1β were also observed in IUA patients’ serum samples, and silencing of NLRP3 rescued cell viability in LPS-treated EPCs. Next, the LPS-treated EPCs were respectively co-cultured with BMSCs in the Transwell system and BMSCs-exo, and the results hinted that both BMSCs and BMSCs-exo reversed the promoting effects of LPS treatment-induced cell death in EPCs. Then, we screened out miR-223-3p, as the upstream regulator for NLRP3, was enriched in BMSCs-exo, and BMSCs-exo inactivated NLRP3-mediated cell pyroptosis in EPCs via delivering miR-223-3p. Interestingly, upregulation of miR-223-3p attenuated LPS-induced cell death in EPCs. Collectively, we concluded that BMSCs-exo upregulated miR-223-3p to degrade NLRP3 in EPCs, which further reversed the cytotoxic effects of LPS treatment on EPCs to ameliorate LPS-induced AUI.
DOI: 10.6084/m9.figshare.17134667
title: Supplementary Material for: Post-Progression Treatments after Palbociclib plus Endocrine Therapy in HR+/HER2– Metastatic Breast Cancer Patients: What Is the Better Choice?

description: Background: To date, a consensus has not yet been reached about the therapy sequence after disease progression (PD) on CDK4/6 inhibitors in patients with HR+/HER2- metastatic breast cancer (MBC). Objectives: The present study assesses, in a real-world setting, the activity of different subsequent therapies in patients who experienced a PD on palbociclib (P) + endocrine therapy (ET), to evaluate the best therapy sequence. Methods: This is a multicenter retrospective observational study. Records of consecutive HR+/HER2- MBC patients from January 2017 to May 2019 were reviewed. The primary endpoint was the evaluation of progression-free survival (PFS) according to subsequent treatment lines after progression on P+ET. Toxicity data were also collected. Results: The outcomes were analyzed in 89 MBC patients that had progressed on previous P+ET: 17 patients were on hormone therapy (HT) and 31 patients on chemotherapy (CT) as second-line treatments; seven patients were on HT and 34 on CT as third-line therapies. PFS of patients treated with HT as second-line therapy is significantly improved when compared with patients treated with CT (p=0.01). Considering third-line settings, the difference in PFS was not statistically different between HT and CT. A better outcome in terms of toxicity is observed among HT patients for both second- and third-line therapies. Conclusions: patients who were progressive on P+ET could still benefit from a subsequent ET. In patients who experienced a good efficacy from prior ET, without visceral metastatic sites, HT seems the most suitable option, when compared to CT, also in terms of safety.
DOI: 10.6084/m9.figshare.17134667.v1
title: Supplementary Material for: Post-Progression Treatments after Palbociclib plus Endocrine Therapy in HR+/HER2– Metastatic Breast Cancer Patients: What Is the Better Choice?

description: Background: To date, a consensus has not yet been reached about the therapy sequence after disease progression (PD) on CDK4/6 inhibitors in patients with HR+/HER2- metastatic breast cancer (MBC). Objectives: The present study assesses, in a real-world setting, the activity of different subsequent therapies in patients who experienced a PD on palbociclib (P) + endocrine therapy (ET), to evaluate the best therapy sequence. Methods: This is a multicenter retrospective observational study. Records of consecutive HR+/HER2- MBC patients from January 2017 to May 2019 were reviewed. The primary endpoint was the evaluation of progression-free survival (PFS) according to subsequent treatment lines after progression on P+ET. Toxicity data were also collected. Results: The outcomes were analyzed in 89 MBC patients that had progressed on previous P+ET: 17 patients were on hormone therapy (HT) and 31 patients on chemotherapy (CT) as second-line treatments; seven patients were on HT and 34 on CT as third-line therapies. PFS of patients treated with HT as second-line therapy is significantly improved when compared with patients treated with CT (p=0.01). Considering third-line settings, the difference in PFS was not statistically different between HT and CT. A better outcome in terms of toxicity is observed among HT patients for both second- and third-line therapies. Conclusions: patients who were progressive on P+ET could still benefit from a subsequent ET. In patients who experienced a good efficacy from prior ET, without visceral metastatic sites, HT seems the most suitable option, when compared to CT, also in terms of safety.
DOI: 10.15161/oar.it/74307
title: CovidStat project data

description: This record contains the daily updated data of the CovidStat project. CovidStat is a project carried out by the CovidStat Working Group at INFN, whose creation was promoted within the Italian National Institute of Nuclear Physics with the aim of making a statistical analysis of the data provided daily by the Civil Protection on the spread of the pandemic in Italy. CovidStat data can interactively be browsed at https://covid19.infn.it.
description: The software to process this Root TTree is in the related identifier. Be sure to use the right corresponding version, based on the data in which Root TTree was generated.
DOI: 10.5523/bris.2bviu59ktwxng2qq6jmafd8p54
title: Behaviour change to improve oral hygiene

description: Anonymised clinical and questionnaire data from baseline and visit2. PIS and consent form also uploaded
DOI: 10.6084/m9.figshare.17134688
title: Supplementary Material for: Immunoadsorption Improves Remission Rates of Patients with Antineutrophil Cytoplasmic Antibody-Associated Vasculitis and Severe Kidney Involvement

description: <b><i>Introduction:</i></b> The role of plasma exchange in treatment of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) with severe kidney involvement is controversial. It is urgent to find effective treatments to improve prognosis of AAV patients. In this retrospective study, the outcomes of immunoadsorption (IA) onto protein A in AAV patients with severe kidney involvement were evaluated. <b><i>Methods:</i></b> Clinical data of 60 patients with AAV and severe kidney involvement were analyzed. Patients received cyclophosphamide or rituximab for remission induction, among which 16 were additionally treated with IA. Remission, end-stage kidney disease (ESKD), death, and relapse were compared. <b><i>Results:</i></b> Of 60 patients, 56 patients (93.3%) were positive for myeloperoxidase (MPO)-ANCA. At diagnosis, the estimated glomerular filtration rate and Birmingham Vasculitis Activity Score (BVAS) was 13.0 (7.7, 18.7) mL/min/1.73 m<sup>2</sup> and 11.1 ± 3.4, respectively. After 3–17 days (mean 10.4 days) of induction treatment, the disease activity decreased more obviously in the IA group (<i>p</i> = 0.022) than the control group. IA showed superior over standard regimen in clearance of MPO-ANCA within 3–31 days (median 11 days) after treatment (78.4% vs. 9.3%, <i>p</i> = 0.005). After a median follow-up of 20.2 months, remission was achieved more quickly (<i>p</i> = 0.035) and higher (hazard ratio (HR) = 2.3, 95% confidence interval (CI): 1.1∼7.2<i>, p</i> = 0.033) in the IA group than the control group. IA therapy showed an advantage in reducing death (HR = 0.2, 95% CI: 0.1∼0.9<i>, p</i> = 0.032). There was no difference in developing into ESKD in both groups (HR = 0.7, 95% CI: 0.3∼2.0<i>, p</i> = 0.504). Multivariate Cox regression analysis indicated that early-stage remission was an independent predictor for ESKD (HR = 0.03, 95% CI: 0.003∼0.25, <i>p</i> = 0.001) and death (HR = 0.07, 95% CI: 0.01∼0.51, <i>p</i> = 0.009). <b><i>Conclusion:</i></b> IA treatment induces quicker and higher remission and lower mortality in AAV patients with severe kidney involvement. The early remission independently predicts the outcomes for these patients.
DOI: 10.5255/ukda-sn-855312
title: Ageing in and Out of Place: Towards Sustainable Wellbeing in Diverse and Mobile Contexts, 2018-2019

description: These data stem from the Sustainable Care Research Programme (2017-2021), which investigated how social care arrangements can be made sustainable. The main objective of the programme was to increase understanding of economically and socially sustainable care – especially how to achieve wellbeing for care users, their families/ carers and paid care workers. The Sustainable Care research programme was comprised of several Work Packages, one of them being Care ‘In’ and ‘Out’ of Place: towards sustainable wellbeing in mobile and diverse contexts. These data are from that specific Work Package. It aimed to examine migrants’ experiences of care in and out of place, in order to develop understandings of sustainable wellbeing. It focused on two groups: ageing migrants in England and ageing British migrants in Spains.
DOI: 10.5517/ccdc.csd.cc28g4lh
title: CCDC 2098966: Experimental Crystal Structure Determination

description: Related Article: Ping Lu|2021|CSD Communication|||
description: Related Article: Jun Chen, Zhan Shi, Ping Lu|2021|Org.Lett.|23|7359|doi:10.1021/acs.orglett.1c02513
DOI: 10.5517/ccdc.csd.cc28g4mj
title: CCDC 2098967: Experimental Crystal Structure Determination

description: Related Article: Ping Lu|2021|CSD Communication|||
description: Related Article: Jun Chen, Zhan Shi, Ping Lu|2021|Org.Lett.|23|7359|doi:10.1021/acs.orglett.1c02513
DOI: 10.5517/ccdc.csd.cc28jvb0
title: CCDC 2101562: Experimental Crystal Structure Determination

description: Related Article: Olga G. Shakirova, Dmitry Yu. Naumov, Ludmila G. Lavrenova, Sergei K. Petkevich, Vladimir I. Potkin|2021|CSD Communication|||
description: Related Article: O.G. Shakirova, D.Yu. Naumov, L.G. Lavrenova, S.K. Petkevich, V.I. Potkin|2021|Inorg.Chem.Commun.|133|108957|doi:10.1016/j.inoche.2021.108957
DOI: 10.5517/ccdc.csd.cc28jxb2
title: CCDC 2101624: Experimental Crystal Structure Determination

description: Related Article: madhukar Said|2021|CSD Communication|||
description: Related Article: Nilesh S. Khonde, Madhukar S. Said, Jagjivan K. Sabane, Jayant M. Gajbhiye, Pradeep Kumar|2021|Tetrahedron|101|132510|doi:10.1016/j.tet.2021.132510
DOI: 10.5517/ccdc.csd.cc2709yj
title: CCDC 2055887: Experimental Crystal Structure Determination

description: Related Article: Tingyan Ye|2021|CSD Communication|||
description: Related Article: Tingyan Ye, Gaolei Hou, Wen Li, Chaofeng Wang, Kangyan Yi, Nannan Liu, Jian Liu, Shaoming Huang, Jun Gao|2021|Nat.Commun.|12|5231|doi:10.1038/s41467-021-25597-1
DOI: 10.21227/e84y-5t74
title: How do table shape, group size, and gender affect on-task actions in collaborative learning activities?

description: Abstract—Contribution: This paper presents a study that adds evidence to the field of computer education by focusing on the interaction between shapes of tables, group size and gender, and their effects on on-task collaborative learning actions. By studying the collaborative learning environment in the context of computer education, the aim is to understand how different on-task actions are affected by mentioned factors.Background: Previous research on collaborative learning space in the collaborative computer education context with the focus on the group formation, gender aspect and analysis of on-task actions.Research questions: Do different table shapes have different effects on open-ended computer education on-task actions for different groups sizes (2 and 3 participants) and for different genders?Methodology: In order to study a collaborative problem-solving activity that is based on creating a prototype of a responsive toy, two main conditions were examined: table shape (round or rectangular) and how this interacts with group size (two or three participants) and gender. University students were engaged in design tasks conducted in small groups following the Jigsaw pattern.Findings: Results show that students engage more in interaction with physical artefacts when collaboration is conducted in dyads. In terms of gender, the analysis shows a tendency of female students to engage more when the activity is conducted in dyads. Furthermore, the combination of dyad structure and a round table resulted in more discussion and nonverbal interaction.
DOI: 10.6084/m9.figshare.17134679
title: Consensus on activities and assessment methods that instil interprofessional core competencies (data sets)

description: Delphi round 1 Suggested activities and assessments made by the participants for the IPE core competencies were ranked and captured accordingly. Delphi Round Two Fourteen of the experts participated in this round. The suggestions given for activities and assessment strategies that were common to the majority of participants were summarised and sent back to the participants for confirmation in the form of round two. Participants were requested to rate common suggestions on activities and assessments given as Likert items (see Table 2 and Table 3) and make necessary comments should there be any discrepancies.
DOI: 10.6084/m9.figshare.17134679.v1
title: Consensus on activities and assessment methods that instil interprofessional core competencies (data sets)

description: Delphi round 1 Suggested activities and assessments made by the participants for the IPE core competencies were ranked and captured accordingly. Delphi Round Two Fourteen of the experts participated in this round. The suggestions given for activities and assessment strategies that were common to the majority of participants were summarised and sent back to the participants for confirmation in the form of round two. Participants were requested to rate common suggestions on activities and assessments given as Likert items (see Table 2 and Table 3) and make necessary comments should there be any discrepancies.
DOI: 10.1285/i22390359v45
title: Experiencing Shakespeare in Digital Environments

description: This special issue on Experiencing Shakespeare in Digital Environments explores the new frontiers of textual and performative spaces opened up by digital media in Shakespeare Studies. Against the background of the ongoing scholarly debate, where the outcomes of digital culture and their far-reaching implications have been examined from a variety of perspectives, the volume identifies three main areas of investigation. The articles of the first section illustrate how increasingly interactive and cross-networked digital environments affect our ways of approaching Shakespeare's textuality. They touch on a variety of topics that are gaining prominence in the debate, ranging from the digital turn in textual transmission and editorial mediation to the newly available tools and methodologies in source studies and Shakespeare pedagogy, with an eye to the specific cognitive, reading and learning abilities of digital natives. The second section investigates the changing notions of performance against the innovative modes of cross-mediality, trans-mediality, and inter-mediality. It dwells on how the remediation of theatre into the digital media circuit has not only problematized the concept of 'liveness' as an essential component of the medium itself but has implied the creation of hybrid products and all sorts of paratexts that need to be understood within new models of global and local communication. As the articles included in this section show, Shakespearean performances – whether they are produced and put on in traditional 'centres', like the Globe in London, or in the elsewheres of the world – are growingly broadcast through digital channels: they therefore constantly dialogue with each other thus assuming intercultural meanings that challenge established ways of interpreting and criticizing Shakespeare. The third section is concerned with a broad spectrum of ways in which digital technologies impact the performance, adaptation and transmission of Shakespeare's works. Including discussions of Shakespeare DVDs, internet memes, televisual hacks, Virtual Reality (VR) installations and a live streaming broadcast from a prison, the contributions contemplate how the digital, in its myriad guises, permeates and updates both the production and reception of Shakespearean codes.
DOI: 10.1285/i22390359v45p1
title: Title page
DOI: 10.1285/i22390359v45p5
title: Table of contents
DOI: 10.6084/m9.figshare.17134718
title: Validity of automated audiometry

description: This was a cross-sectional comparative study with a retrospective approach, using patient medical records. Patient with multidrug-resistant tuberculosis (MDR-TB) were recruited based-on medical records that met the inclusion and exclusion criteria at the Pulmonology outpatient unit
DOI: 10.6084/m9.figshare.17134718.v1
title: Validity of automated audiometry

description: This was a cross-sectional comparative study with a retrospective approach, using patient medical records. Patient with multidrug-resistant tuberculosis (MDR-TB) were recruited based-on medical records that met the inclusion and exclusion criteria at the Pulmonology outpatient unit
DOI: 10.1285/i22390359v45p7
title: Introduction

description: Introduction to the volume
DOI: 10.1285/i22390359v45p23
title: Part I - The digital turn in textual studies, scholarly editing and pedagogy
DOI: 10.1285/i22390359v45p25
title: "Such stuff as 'texts' are made on". Digital Materialities and (Hyper)editing in The Internet Shakespeare Edition of 'King Lear'

description: Against the background of increasingly pervasive digital technologies, much scholarly attention has been attracted, over the last few decades, by the impact of digital tools and resources in the field of Shakespearean textual studies, where several issues are still open to debate (Erne 2021; Estill 2019; Lavagnino 2014; Malone, Greatley-Hirsch 2021; Greatley-Hirsch, Jenstad 2016; Massai 2021). In the light of a radical rethinking of the 'materiality' of the text, this article more specifically addresses some of the affordances, as well as the possible dangers and prospects of digital scholarly editions of the playwright's works. Focusing on Michael Best's Internet Shakespeare Edition of King Lear (2001) as a remarkable case in point, the article illustrates how print-based views of textual transmission and editorial mediation are radically reconceptualized within an interactive environment (Driscoll, Pierazzo 2016) where readers are allowed to navigate across the diverse textual variants of the play, including old-spelling transcriptions of the early witnesses, and to access a huge amount of multimedia materials available at the click of the mouse (Best 2011). Considering the paradigm shift from 'editing' to 'archiving' (Desmet 2017; Galey 2014) and the more recent expansion of platforms hosting interoperable digital humanities projects (Jenstad et al. 2018; Malone, Greatley-Hirsch 2021), the article eventually illustrates how, in the wake of Best's pioneering model, a digital edition of King Lear could be further enhanced with dynamic links to other interoperable resources and tools. Their still partly unexplored hermeneutic potential invites reflection on how the affordances of the digital medium affect our engagement with and understanding of Shakespeare's textual heritage.
DOI: 10.1285/i22390359v45p53
title: Link It "to the source from when it came". Shakespeare Source Study after the Digital Turn

description: This paper discusses the digitally inflected changes occurring in Shakespeare source study – a long-standing research field that burst back into prominence over the last few years. The recent publication of volumes such as Shakespeare, Origins, and Originality (Holland 2015), Rethinking Shakespeare Source Study (Britton, Walter 2018) or Shakespeare's Resources (Drakakis in press) vouches indeed for a steady resurgence of interest in "the circulation, transformation and function of Shakespeare's sources" (Bigliazzi 2018, p. 13) – a rising tide heightened, no doubt, by the proliferation of electronic archives, digital critical editions, wiki databases, and corpus-based searching tools designed to bring early modern (inter)textuality into sharper focus. This "flood of digital possibilities" (Lavagnino 2014, p. 21) has greatly impacted on Shakespeare source criticism, modelling new ways to explore and identify the intertextual, subtextual, and contextual forms of influence that shaped the playwright's production. In this essay, such an ongoing shift of perspectives is examined by sorting through a series of digital methodologies and resources that show promise in improving how we visualise, analyse, and identify Shakespeare's diverse sources. Laying emphasis on the dovetailing of "'old source study' and more contemporary approaches to textual and cultural analysis" (Britton, Walter 2018, p. 1) fostered by the digital medium, the paper illustrates the benefits, limits, and prospects of digital editing and archiving, quantitative analyses, wiki databases, and digital thick mapping for the study of Shakespeare's creative process and early modern European theatricality tout court.