cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.12340724.v10
title: The type I-E CRISPR-Cas system influences the acquisition of <i>bla</i> <sub>KPC</sub>-IncF plasmid in <i>Klebsiella pneumonia</i>

description: <i>Klebsiella pneumoniae</i> carbapenemase (KPC)-producing <i>K. pneumoniae</i> (KPC-KP) have disseminated worldwide and emerged as major threats to public health. Of epidemiological significance, the international pandemic of KPC-KP is primarily associated with CG258 isolates and <i>bla</i>
 <sub>KPC</sub>-IncF plasmids. CRISPR-Cas system is an adaptive immune system that can hinder gene expansion driven by horizontal gene transfer. Because of <i>bla</i>
 <sub>KPC</sub>-IncF plasmids are favored by CG258 <i>K. pneumoniae,</i> it was of interest to examine the co-distribution of CRISPR and <i>bla</i>
 <sub>KPC</sub>-IncF plasmids in such isolates. We collected 459 clinical <i>K. pneumoniae isolates</i> in China and collected 203 global whole-genome sequences in GenBank to determine the prevalence of CRISPR-Cas systems. We observed that CRISPR-Cas system was significantly scarce in the CG258 lineage and <i>bla</i>
 <sub>KPC</sub>-positive isolates. Furthermore, the results of conjugation and plasmid stability assay fully demonstrated the CRIPSR-Cas system in <i>K. pneumoniae</i> could effectively hindered <i>bla</i>
 <sub>KPC</sub>-IncF plasmids invasion and existence. Notably, most <i>bla</i>
 <sub>KPC</sub>-IncF plasmids were also proved to be good targets of CRISPR owing to carry matched and functional protospacers and PAMs. Overall, our work suggests that type I-E CRISPR-Cas systems could impact the spread of <i>bla</i>
 <sub>KPC</sub> in <i>K. pneumoniae</i> populations, and the scarcity of CRISPR-Cas system was one of potential factors leading to the propagation of <i>bla</i>
 <sub>KPC</sub>-IncF plasmids in CG258 <i>K. pneumoniae</i>.
DOI: 10.6084/m9.figshare.12340724.v6
title: The type I-E CRISPR-Cas system influences the acquisition of <i>bla</i> <sub>KPC</sub>-IncF plasmid in <i>Klebsiella pneumonia</i>

description: <i>Klebsiella pneumoniae</i> carbapenemase (KPC)-producing <i>K. pneumoniae</i> (KPC-KP) have disseminated worldwide and emerged as major threats to public health. Of epidemiological significance, the international pandemic of KPC-KP is primarily associated with CG258 isolates and <i>bla</i>
 <sub>KPC</sub>-IncF plasmids. CRISPR-Cas system is an adaptive immune system that can hinder gene expansion driven by horizontal gene transfer. Because of <i>bla</i>
 <sub>KPC</sub>-IncF plasmids are favored by CG258 <i>K. pneumoniae,</i> it was of interest to examine the co-distribution of CRISPR and <i>bla</i>
 <sub>KPC</sub>-IncF plasmids in such isolates. We collected 459 clinical <i>K. pneumoniae isolates</i> in China and collected 203 global whole-genome sequences in GenBank to determine the prevalence of CRISPR-Cas systems. We observed that CRISPR-Cas system was significantly scarce in the CG258 lineage and <i>bla</i>
 <sub>KPC</sub>-positive isolates. Furthermore, the results of conjugation and plasmid stability assay fully demonstrated the CRIPSR-Cas system in <i>K. pneumoniae</i> could effectively hindered <i>bla</i>
 <sub>KPC</sub>-IncF plasmids invasion and existence. Notably, most <i>bla</i>
 <sub>KPC</sub>-IncF plasmids were also proved to be good targets of CRISPR owing to carry matched and functional protospacers and PAMs. Overall, our work suggests that type I-E CRISPR-Cas systems could impact the spread of <i>bla</i>
 <sub>KPC</sub> in <i>K. pneumoniae</i> populations, and the scarcity of CRISPR-Cas system was one of potential factors leading to the propagation of <i>bla</i>
 <sub>KPC</sub>-IncF plasmids in CG258 <i>K. pneumoniae</i>.
DOI: 10.6084/m9.figshare.12340724.v15
title: The type I-E CRISPR-Cas system influences the acquisition of <i>bla</i><sub>KPC</sub>-IncF plasmid in <i>Klebsiella pneumonia</i>

description: <i>Klebsiella pneumoniae</i> carbapenemase (KPC)-producing <i>K. pneumoniae</i> (KPC-KP) have disseminated worldwide and emerged as major threats to public health. Of epidemiological significance, the international pandemic of KPC-KP is primarily associated with CG258 isolates and <i>bla</i><sub>KPC</sub>-IncF plasmids. CRISPR-Cas system is an adaptive immune system that can hinder gene expansion driven by horizontal gene transfer. Because of <i>bla</i><sub>KPC</sub>-IncF plasmids are favored by CG258 <i>K. pneumoniae,</i> it was of interest to examine the co-distribution of CRISPR and <i>bla</i><sub>KPC</sub>-IncF plasmids in such isolates. We collected 459 clinical <i>K. pneumoniae isolates</i> in China and collected 203 global whole-genome sequences in GenBank to determine the prevalence of CRISPR-Cas systems. We observed that CRISPR-Cas system was significantly scarce in the CG258 lineage and <i>bla</i><sub>KPC</sub>-positive isolates. Furthermore, the results of conjugation and plasmid stability assay fully demonstrated the CRIPSR-Cas system in <i>K. pneumoniae</i> could effectively hindered <i>bla</i><sub>KPC</sub>-IncF plasmids invasion and existence. Notably, most <i>bla</i><sub>KPC</sub>-IncF plasmids were also proved to be good targets of CRISPR owing to carry matched and functional protospacers and PAMs. Overall, our work suggests that type I-E CRISPR-Cas systems could impact the spread of <i>bla</i><sub>KPC</sub> in <i>K. pneumoniae</i> populations, and the scarcity of CRISPR-Cas system was one of potential factors leading to the propagation of <i>bla</i><sub>KPC</sub>-IncF plasmids in CG258 <i>K. pneumoniae</i>.
DOI: 10.6084/m9.figshare.12340724.v8
title: The type I-E CRISPR-Cas system influences the acquisition of <i>bla</i> <sub>KPC</sub>-IncF plasmid in <i>Klebsiella pneumonia</i>

description: <i>Klebsiella pneumoniae</i> carbapenemase (KPC)-producing <i>K. pneumoniae</i> (KPC-KP) have disseminated worldwide and emerged as major threats to public health. Of epidemiological significance, the international pandemic of KPC-KP is primarily associated with CG258 isolates and <i>bla</i>
 <sub>KPC</sub>-IncF plasmids. CRISPR-Cas system is an adaptive immune system that can hinder gene expansion driven by horizontal gene transfer. Because of <i>bla</i>
 <sub>KPC</sub>-IncF plasmids are favored by CG258 <i>K. pneumoniae,</i> it was of interest to examine the co-distribution of CRISPR and <i>bla</i>
 <sub>KPC</sub>-IncF plasmids in such isolates. We collected 459 clinical <i>K. pneumoniae isolates</i> in China and collected 203 global whole-genome sequences in GenBank to determine the prevalence of CRISPR-Cas systems. We observed that CRISPR-Cas system was significantly scarce in the CG258 lineage and <i>bla</i>
 <sub>KPC</sub>-positive isolates. Furthermore, the results of conjugation and plasmid stability assay fully demonstrated the CRIPSR-Cas system in <i>K. pneumoniae</i> could effectively hindered <i>bla</i>
 <sub>KPC</sub>-IncF plasmids invasion and existence. Notably, most <i>bla</i>
 <sub>KPC</sub>-IncF plasmids were also proved to be good targets of CRISPR owing to carry matched and functional protospacers and PAMs. Overall, our work suggests that type I-E CRISPR-Cas systems could impact the spread of <i>bla</i>
 <sub>KPC</sub> in <i>K. pneumoniae</i> populations, and the scarcity of CRISPR-Cas system was one of potential factors leading to the propagation of <i>bla</i>
 <sub>KPC</sub>-IncF plasmids in CG258 <i>K. pneumoniae</i>.
DOI: 10.6084/m9.figshare.6049331
title: Triethylenetetramine/hydroxyethyl cellulose-functionalized graphene oxide monoliths for the removal of copper and arsenate ions

description: Nitrogen-doped graphene oxide monoliths (GOMs) were readily constructed by crosslinking graphene oxide (GO) using triethylenetetramine (TETA) and hydroxyethyl cellulose (HEC). The addition of HEC was beneficial to the formation of a network structure compared to that in the absence of HEC. The generated monoliths have shown various morphologies with different d spacing, layer thickness, and micropore size. Fourier transform infrared (FTIR) and X-ray photoelectron spectroscopy (XPS) analyses provided evidences for the formation of covalent C–N bonds and some nitrogen-containing heterocyclic composition inside the graphene oxide sheet, indicating that the interaction of GO with the amine crosslinker involved the crosslinking reaction between GO epoxides and amine groups. HEC was also involved in the N-doping reaction via the partial reduction of oxygen in HEC molecules. Analysis of X-ray diffraction (XRD) results indicated that the lattice distance between GO sheets increased after TETA/HEC crosslinking. Thermogravimetric analysis (TGA) confirmed the successful incorporation of crosslinker moieties on the surface of GO sheets. The fabricated GOMs could be used to efficiently adsorb metal ions and arsenate by the introduced polar functional groups on GO sheets and porous structures based on hydrogen bonds, whose morphologies and compositions were confirmed via XRD, scanning electron microscopy (SEM) and energy-dispersive X-ray spectroscopy (EDS).
DOI: 10.6084/m9.figshare.12340793
title: Additional file 2 of High expression of ESRP1 regulated by circ-0005585 promotes cell colonization in ovarian cancer

description: Additional file 2: Tables S1–S3. Catalog numbers of miRs mimics, primer sequences and ESRP1-related miRs matrix.
DOI: 10.6084/m9.figshare.20729334.v1
title: EXPERIMENTAL STUDY OF EXERCISE PRESCRIPTION INTERVENTION ON THE UNIVERSITY STUDENTS’ HEALTH

description: ABSTRACT Introduction Disparate to the development of society, health indices in Chinese college students have shown a pronounced decline in recent years. Government concern over this recent challenge has encouraged research for practical solutions, including optimized physical activity protocols. Objective Explore the effects of an exercise intervention on the health of Chinese university students. Methods Full-time university students (80 males and 55 females) were selected and randomly assigned into two groups. Before and after the experiment, the college students’ body composition scale and exercise experience were tested, focusing on the relationship between exercise prescription and changes in physical and mental health indicators. Results The body fat percentage of male and female students decreased significantly after the experiment. After eight weeks of the exercise prescription experiment, the weight of male and female college students was controlled or reduced. The suggested exercise prescription achieved a good moderating effect on the weight of the volunteers. There was a significant difference between the two groups, indicating that the experiment had a beneficial effect on vital capacity (p&lt;0.01). Conclusion The suggested exercise prescription proved to be feasible to guide and intervene in the physical exercise of college students aiming at a beneficial impact on the physical health of college students. Level of evidence II; Therapeutic studies - investigation of treatment outcomes.
DOI: 10.6084/m9.figshare.12340823
title: Additional file 3 of Circular RNA circMET drives immunosuppression and anti-PD1 therapy resistance in hepatocellular carcinoma via the miR-30-5p/snail/DPP4 axis

description: Additional file 3: Table S3. Snail-binding sites in the snail CHIp-seq.
DOI: 10.6084/m9.figshare.12340823.v1
title: Additional file 3 of Circular RNA circMET drives immunosuppression and anti-PD1 therapy resistance in hepatocellular carcinoma via the miR-30-5p/snail/DPP4 axis

description: Additional file 3: Table S3. Snail-binding sites in the snail CHIp-seq.
DOI: 10.6084/m9.figshare.6049280
title: Partial melting of subducted Southern Qiangtang crust in northern Tibet: evidence from the geochemistry and geochronology of the Riwanchaka granodiorite porphyry in Central Qiangtang

description: This article presents new zircon U–Pb geochronology, Hf isotopic, and whole-rock major- and trace-element geochemical data that provide insights into the petrogenesis and tectonic history of the Riwanchaka granodiorite porphyries of Central Qiangtang, Tibet. Zircon U–Pb ages of 236–230 Ma indicate an early Late Triassic age of emplacement of the porphyries, and zircon Hf isotopic data yield εHf(t) values of – 7.0 to – 1.5 and ancient zircon Hf crustal model ages (T<sub>DM</sub><sup>C</sup>) of 1524–1220 Ma. The granodiorite porphyries are characterized by low K<sub>2</sub>O contents, high Mg# values, and relatively high Cr and Ni contents. They are classified as I-type calc-alkaline granite and are considered to have formed through the anatexis of ancient mafic crustal rocks with contributions from mantle-derived components. The geochemistry and isotopic compositions of all samples are similar to those of magmatic rocks that originated in the South Qiangtang crust. However, field observations indicate that the pluton intrudes the North Qiangtang crust, and we propose that the granodiorite porphyries were derived by partial melting of subducted continental crust of the South Qiangtang terrane. These new data have been integrated with data from previous studies to construct a new model of slab rollback during northward subduction of the Southern Qiangtang continental crust at <i>ca</i>. 245–226 Ma, thereby improving our understanding of magmatic processes involved in continental subduction in collision settings.
DOI: 10.6084/m9.figshare.12340793.v1
title: Additional file 2 of High expression of ESRP1 regulated by circ-0005585 promotes cell colonization in ovarian cancer

description: Additional file 2: Tables S1–S3. Catalog numbers of miRs mimics, primer sequences and ESRP1-related miRs matrix.
DOI: 10.6084/m9.figshare.12340811
title: Additional file 2 of Circular RNA circMET drives immunosuppression and anti-PD1 therapy resistance in hepatocellular carcinoma via the miR-30-5p/snail/DPP4 axis

description: Additional file 2: Table S2. The expressed genes in HepG2-circMET and HepG2-Mock.
DOI: 10.6084/m9.figshare.12340811.v1
title: Additional file 2 of Circular RNA circMET drives immunosuppression and anti-PD1 therapy resistance in hepatocellular carcinoma via the miR-30-5p/snail/DPP4 axis

description: Additional file 2: Table S2. The expressed genes in HepG2-circMET and HepG2-Mock.
DOI: 10.6084/m9.figshare.20727743
title: Additional file 11 of Transcriptomic and metabolomic profiling of flavonoid biosynthesis provides novel insights into petals coloration in Asian cotton (Gossypium arboreum L.)

description: Additionalfile 11: Table S6. The primers for the qRT-PCR used in this study.
DOI: 10.6084/m9.figshare.20727542
title: Additional file 1 of Proteome-wide analysis of lysine 2-hydroxyisobutyrylation in Frankliniella occidentalis

description: Additional file 1:
DOI: 10.5281/zenodo.10664430
title: Dataset related to: Efficacy of GalNAc C3 siRNAs in factor H-deficient mice with C3 glomerulopathy

description: The .xlsx files contain all the dataset included in the manuscript divided by figures.

Abstract Complement alternative pathway (AP) dysregulation drives C3 glomerulopathy (C3G), a rare renal disorder characterized by glomerular C3 deposition and glomerular damage, for which no effective treatments are available. Blockade of complement C3 is emerging as a viable therapeutic option. In an earlier study we showed that SLN500, a small interfering RNA targeting liver C3 synthesis, ¬was able to limit AP dysregulation and glomerular C3d deposits in mice with partial factor H (FH) deficiency (Cfh+/- mice). Here, we assessed the pharmacological effects of SLN501 – an optimized SLN500 version – in mice with complete FH deficiency (Cfh-/- mice) that exhibit a more severe C3G phenotype. SLN501 effectively prevented liver C3 synthesis, thus limiting AP dysregulation, glomerular C3d deposits and the development of ultrastructural alterations. These data provide firm evidence of the use of siRNA-mediated liver C3 gene silencing as a potential therapy for treating C3G patients with either partial or complete FH loss of function.
description: For raw data please send your request to Corresponding Author.
DOI: 10.5281/zenodo.10664431
title: Dataset related to: Efficacy of GalNAc C3 siRNAs in factor H-deficient mice with C3 glomerulopathy

description: The .xlsx files contain all the dataset included in the manuscript divided by figures.

Abstract Complement alternative pathway (AP) dysregulation drives C3 glomerulopathy (C3G), a rare renal disorder characterized by glomerular C3 deposition and glomerular damage, for which no effective treatments are available. Blockade of complement C3 is emerging as a viable therapeutic option. In an earlier study we showed that SLN500, a small interfering RNA targeting liver C3 synthesis, ¬was able to limit AP dysregulation and glomerular C3d deposits in mice with partial factor H (FH) deficiency (Cfh+/- mice). Here, we assessed the pharmacological effects of SLN501 – an optimized SLN500 version – in mice with complete FH deficiency (Cfh-/- mice) that exhibit a more severe C3G phenotype. SLN501 effectively prevented liver C3 synthesis, thus limiting AP dysregulation, glomerular C3d deposits and the development of ultrastructural alterations. These data provide firm evidence of the use of siRNA-mediated liver C3 gene silencing as a potential therapy for treating C3G patients with either partial or complete FH loss of function.
description: For raw data please send your request to Corresponding Author.
DOI: 10.6084/m9.figshare.20727755.v1
title: Additional file 2 of Transcriptomic and metabolomic profiling of flavonoid biosynthesis provides novel insights into petals coloration in Asian cotton (Gossypium arboreum L.)

description: Additionalfile 2: Table S1. The classification and quantification results of all flavonoid metabolites.
DOI: 10.6084/m9.figshare.20727743.v1
title: Additional file 11 of Transcriptomic and metabolomic profiling of flavonoid biosynthesis provides novel insights into petals coloration in Asian cotton (Gossypium arboreum L.)

description: Additionalfile 11: Table S6. The primers for the qRT-PCR used in this study.
DOI: 10.17188/1193160
title: Materials Data on Nd2SiTeO4 by Materials Project

description: Nd2SiTeO4 crystallizes in the orthorhombic Pbcm space group. The structure is three-dimensional. there are two inequivalent Nd3+ sites. In the first Nd3+ site, Nd3+ is bonded in a 6-coordinate geometry to four equivalent Te2- and six O2- atoms. There are two shorter (3.36 Å) and two longer (3.70 Å) Nd–Te bond lengths. There are four shorter (2.53 Å) and two longer (2.55 Å) Nd–O bond lengths. In the second Nd3+ site, Nd3+ is bonded in a 6-coordinate geometry to three equivalent Te2- and six O2- atoms. There are a spread of Nd–Te bond distances ranging from 3.19–3.40 Å. There are a spread of Nd–O bond distances ranging from 2.48–2.63 Å. Si4+ is bonded in a tetrahedral geometry to four O2- atoms. There is two shorter (1.65 Å) and two longer (1.67 Å) Si–O bond length. Te2- is bonded in a 1-coordinate geometry to seven Nd3+ and ten O2- atoms. There are a spread of Te–O bond distances ranging from 3.34–3.72 Å. There are two inequivalent O2- sites. In the first O2- site, O2- is bonded in a 1-coordinate geometry to three Nd3+, one Si4+, and three equivalent Te2- atoms. In the second O2- site, O2- is bonded in a 1-coordinate geometry to three Nd3+, one Si4+, and two equivalent Te2- atoms.
DOI: 10.17188/1193161
title: Materials Data on NaGdGeO4 by Materials Project

description: NaGdGeO4 is Hausmannite-derived structured and crystallizes in the orthorhombic Pnma space group. The structure is three-dimensional. Na1+ is bonded to six O2- atoms to form NaO6 octahedra that share corners with four equivalent GdO6 octahedra, corners with two equivalent GeO4 tetrahedra, edges with two equivalent NaO6 octahedra, edges with two equivalent GdO6 octahedra, and edges with two equivalent GeO4 tetrahedra. The corner-sharing octahedra tilt angles range from 61–67°. There are a spread of Na–O bond distances ranging from 2.43–2.56 Å. Gd3+ is bonded to six O2- atoms to form GdO6 octahedra that share corners with four equivalent NaO6 octahedra, corners with four equivalent GdO6 octahedra, corners with four equivalent GeO4 tetrahedra, edges with two equivalent NaO6 octahedra, and an edgeedge with one GeO4 tetrahedra. The corner-sharing octahedra tilt angles range from 49–67°. There are a spread of Gd–O bond distances ranging from 2.27–2.40 Å. Ge4+ is bonded to four O2- atoms to form GeO4 tetrahedra that share corners with two equivalent NaO6 octahedra, corners with four equivalent GdO6 octahedra, an edgeedge with one GdO6 octahedra, and edges with two equivalent NaO6 octahedra. The corner-sharing octahedra tilt angles range from 46–62°. There are a spread of Ge–O bond distances ranging from 1.75–1.81 Å. There are three inequivalent O2- sites. In the first O2- site, O2- is bonded in a distorted rectangular see-saw-like geometry to one Na1+, two equivalent Gd3+, and one Ge4+ atom. In the second O2- site, O2- is bonded in a rectangular see-saw-like geometry to two equivalent Na1+, one Gd3+, and one Ge4+ atom. In the third O2- site, O2- is bonded in a distorted rectangular see-saw-like geometry to two equivalent Na1+, one Gd3+, and one Ge4+ atom.
DOI: 10.17188/1193162
title: Materials Data on Ba6Mg7F26 by Materials Project

description: Ba6Mg7F26 crystallizes in the orthorhombic Immm space group. The structure is three-dimensional. there are two inequivalent Ba2+ sites. In the first Ba2+ site, Ba2+ is bonded to twelve F1- atoms to form distorted BaF12 cuboctahedra that share corners with two equivalent BaF12 cuboctahedra, a faceface with one BaF12 cuboctahedra, and faces with six MgF6 octahedra. There are a spread of Ba–F bond distances ranging from 2.70–3.04 Å. In the second Ba2+ site, Ba2+ is bonded in a 12-coordinate geometry to twelve F1- atoms. There are a spread of Ba–F bond distances ranging from 2.63–3.29 Å. There are four inequivalent Mg2+ sites. In the first Mg2+ site, Mg2+ is bonded to six F1- atoms to form a mixture of edge and corner-sharing MgF6 octahedra. The corner-sharing octahedra tilt angles range from 48–50°. There are a spread of Mg–F bond distances ranging from 1.99–2.03 Å. In the second Mg2+ site, Mg2+ is bonded to six F1- atoms to form MgF6 octahedra that share corners with four MgF6 octahedra and faces with two equivalent BaF12 cuboctahedra. The corner-sharing octahedra tilt angles range from 2–50°. There are a spread of Mg–F bond distances ranging from 1.94–2.09 Å. In the third Mg2+ site, Mg2+ is bonded to six F1- atoms to form distorted MgF6 octahedra that share corners with three MgF6 octahedra and faces with two equivalent BaF12 cuboctahedra. The corner-sharing octahedra tilt angles range from 0–48°. There are a spread of Mg–F bond distances ranging from 1.99–2.31 Å. In the fourth Mg2+ site, Mg2+ is bonded to six F1- atoms to form MgF6 octahedra that share corners with six MgF6 octahedra and faces with four equivalent BaF12 cuboctahedra. The corner-sharing octahedra tilt angles range from 0–2°. There are two shorter (1.99 Å) and four longer (2.02 Å) Mg–F bond lengths. There are seven inequivalent F1- sites. In the first F1- site, F1- is bonded in a linear geometry to four Ba2+ and two Mg2+ atoms. In the second F1- site, F1- is bonded in a 2-coordinate geometry to two equivalent Ba2+ and two Mg2+ atoms. In the third F1- site, F1- is bonded in a distorted trigonal planar geometry to three Mg2+ atoms. In the fourth F1- site, F1- is bonded in a 2-coordinate geometry to four Ba2+ and two Mg2+ atoms. In the fifth F1- site, F1- is bonded in an L-shaped geometry to two equivalent Ba2+ and two equivalent Mg2+ atoms. In the sixth F1- site, F1- is bonded in a distorted single-bond geometry to three Ba2+ and one Mg2+ atom. In the seventh F1- site, F1- is bonded in a 1-coordinate geometry to three Ba2+ and one Mg2+ atom.