DOI: 10.5061/dryad.2z34tmpvf
title: Data from: effects of phloretin therapy on water and glucose transport during experimental peritoneal dialysis: a dose-response study

description: Unwanted glucose absorption remains a major drawback of peritoneal
 dialysis treatment. Recently we found that phloretin, a non-selective
 blocker of faciltative glucose channels (GLUTs), acts to reduce glucose
 absorption thereby improving osmotic water removal during peritoneal
 dialysis. Experimental peritoneal dialysis was conducted on fifty healthy
 Sprague-Dawley rats. The animals were exposed to glucose-based dialysis
 fluid containing five different concentrations of phloretin. To determine
 the plasma-to-dialysate transport, we used radiolabeled 18F-deoxyglucose.
description: # Data from: effects of phloretin therapy on water and glucose transport
 during experimental peritoneal dialysis: a dose-response study GENERAL
 INFORMATION 1. Title of Dataset: Dose-Response Relationship Between
 Intra-peritoneal Phloretin Therapy and Water and Glucose Transport during
 Peritoneal Dialysis in Sprague-Dawley rats 2. Author Information A.
 Principal Investigator Contact Information Name: Carl Öberg Institution:
 Lund University, Medical Faculty Address: Box 117, SE-221 00 Email:
 [carl.oberg@med.lu.se](mailto:carl.oberg@med.lu.se) 3. Date of data
 collection June 2022 to September 2023 4. Geographic location of data
 collection: Lund, Sweden 5. Information about funding sources that
 supported the collection of the data: Funding by the Crafoord Foundation,
 Lund University Medical Faculty Foundation grant YF 2020-YF0056, and The
 Inga-Britt and Arne Lundberg’s Research Foundation (all to C.M. Öberg).
 SHARING/ACCESS INFORMATION 1. Licenses/restrictions placed on the data: -
 2. Links to publications that cite or use the data: - 3. Links to other
 publicly accessible locations of the data: - 4. Links/relationships to
 ancillary data sets: - 5. Was data derived from another source? No 6.
 Recommended citation for this dataset: - DATA & FILE OVERVIEW 1. File
 List: phloretindose.xls 2. Relationship between files, if important: - 3.
 Additional related data collected that was not included in the current
 data package: - 4. Are there multiple versions of the dataset? NO
 METHODOLOGICAL INFORMATION 1. Description of methods used for
 collection/generation of data: - 2. Methods for processing the data: - 3.
 Instrument- or software-specific information needed to interpret the data:
 - 4. Standards and calibration information, if appropriate: - 5.
 Environmental/experimental conditions: - 6. Describe any quality-assurance
 procedures performed on the data: - 7. People involved with sample
 collection, processing, analysis and/or submission: - DATA-SPECIFIC
 INFORMATION FOR: phloretindose.xls 1. Number of variables: 130 2. Number
 of cases/rows: 32 3. Variable List: animal, "unique number assigned
 to each animal" treatment, "Phloretin dose (dialysis fluid
 concentration): A: 158 mg/L, B: 50 mg/L, C: 15.8 mg/L, D: 5 mg/L,
 kontroll: 0 mg/L" weight, "Body weight in grams before
 dialysis" date, "Date of the experiment YYYY-MM-DD" vin,
 "Peritoneal dialysis fluid volume instilled in milliliters"
 vout, "Peritoneal dialysis fluid volume extracted in milliliters (see
 manuscript for details)" uvol, "Total urine volume"
 u_fdg_cpm,"18-F activity in urine sample Bq/mL" p_na_mid,
 "Plasma sodium concentration after 30 min (mid sample) dialysis in
 mmol/L" p_k_mid, "Plasma potassium concentration after 30 min
 (mid sample) dialysis in mmol/L" p_cl_mid, "Plasma chloride
 concentration after 30 min (mid sample) dialysis in mmol/L"
 p_ica_mid, "Plasma ionized calcium concentration after 30 min (mid
 sample) dialysis in mmol/L" p_tco2_mid, "Plasma total carbon
 dioxide concentration after 30 min (mid sample) dialysis in mmol/L"
 p_glu_mid, "Plasma glucose concentration after 30 min (mid sample)
 dialysis in mmol/L" p_urea_mid, "Plasma urea concentration after
 30 min (mid sample) dialysis in mmol/L" p_crea_mid, "Plasma
 creatinine concentration after 30 min (mid sample) dialysis in
 mmol/L" map_before, "Mean arterial pressure before dialysis in
 mmol/L" hr_before, "Heart rate before dialysis in mmol/L"
 map_after, "Mean arterial pressure before dialysis in mmol/L"
 hr_after, "Heart rate before dialysis in mmol/L" n_p_samples,
 "Number of blood samples obtained during dialysis" pt1,
 "Time point for blood sample #1 in minutes post start of
 dialysis" pt2, "Time point for blood sample #2 in minutes post
 start of dialysis" pt3, "Time point for blood sample #3 in
 minutes post start of dialysis" pt4, "Time point for blood
 sample #4 in minutes post start of dialysis" pt5, "Time point
 for blood sample #5 in minutes post start of dialysis" hb_mid,
 "Blood hemoglobin concentration 30 min (mid sample) dialysis in
 g/L" hct_mid, "Blood hematocrit 30 min (mid sample)
 dialysis" p_fdg_1, "Plasma 18F activity (blood sample #1) in
 Bq/mL" p_fdg_2, "Plasma 18F activity (blood sample #2) in
 Bq/mL" p_fdg_3, "Plasma 18F activity (blood sample #3) in
 Bq/mL" p_fdg_4, "Plasma 18F activity (blood sample #4) in
 Bq/mL" p_fdg_5, "Plasma 18F activity (blood sample #5) in
 Bq/mL" n_d_samples, "Number of dialysate samples obtained during
 dialysis" d_sv_1, "Sampling volume for dialysate sample #1 in
 milliliters" d_sv_2, "Sampling volume for dialysate sample #2 in
 milliliters" d_sv_3, "Sampling volume for dialysate sample #3 in
 milliliters" d_sv_4, "Sampling volume for dialysate sample #4 in
 milliliters" d_sv_5, "Sampling volume for dialysate sample #5 in
 milliliters" d_sv_6, "Sampling volume for dialysate sample #6 in
 milliliters" d_sv_7, "Sampling volume for dialysate sample #7 in
 milliliters" d_sv_8, "Sampling volume for dialysate sample #8 in
 milliliters" d_fdg_1, "18F activity in dialysate sample #1 in
 Bq/mL" d_fdg_2, "18F activity in dialysate sample #2 in
 Bq/mL" d_fdg_3, "18F activity in dialysate sample #3 in
 Bq/mL" d_fdg_4, "18F activity in dialysate sample #4 in
 Bq/mL" d_fdg_5, "18F activity in dialysate sample #5 in
 Bq/mL" d_fdg_6, "18F activity in dialysate sample #6 in
 Bq/mL" d_fdg_7_1, "18F activity in dialysate sample #7 in
 Bq/mL" d_fdg_7_2, "18F activity in dialysate sample #8 in
 Bq/mL" d_glu_7_1, "Measured glucose concentration in dialysate
 sample #7 in mmol/L" d_glu_7_2, "Measured glucose concentration
 in dialysate sample #8 in mmol/L" d_glu_7_3, "Measured glucose
 concentration in dialysate sample #8 (double) in mmol/L" d_na_0,
 "Sodium concentration in fresh dialysis fluid (before instillation)
 in mmol/L" d_na_1, "Measured glucose concentration in dialysate
 sample #1 in mmol/L" d_na_2, "Measured glucose concentration in
 dialysate sample #2 in mmol/L" d_na_3, "Measured glucose
 concentration in dialysate sample #3 in mmol/L" d_na_4,
 "Measured glucose concentration in dialysate sample #4 in
 mmol/L" d_na_5, "Measured glucose concentration in dialysate
 sample #5 in mmol/L" d_na_6, "Measured glucose concentration in
 dialysate sample #6 in mmol/L" d_na_7, "Measured glucose
 concentration in dialysate sample #7 in mmol/L" d_k_0,
 "Potassium concentration in fresh dialysis fluid (before
 instillation) in mmol/L" d_k_1, "Measured potassium
 concentration in dialysate sample #1 in mmol/L" d_k_2, "Measured
 potassium concentration in dialysate sample #2 in mmol/L" d_k_3,
 "Measured potassium concentration in dialysate sample #3 in
 mmol/L" d_k_4, "Measured potassium concentration in dialysate
 sample #4 in mmol/L" d_k_5, "Measured potassium concentration in
 dialysate sample #5 in mmol/L" d_k_6, "Measured potassium
 concentration in dialysate sample #6 in mmol/L" d_k_7, "Measured
 potassium concentration in dialysate sample #7 in mmol/L" d_cl_0,
 "Chloride concentration in fresh dialysis fluid (before instillation)
 in mmol/L" d_cl_1, "Measured chloride concentration in dialysate
 sample #1 in mmol/L" d_cl_2, "Measured chloride concentration in
 dialysate sample #2 in mmol/L" d_cl_3, "Measured chloride
 concentration in dialysate sample #3 in mmol/L" d_cl_4,
 "Measured chloride concentration in dialysate sample #4 in
 mmol/L" d_cl_5, "Measured chloride concentration in dialysate
 sample #5 in mmol/L" d_cl_6, "Measured chloride concentration in
 dialysate sample #6 in mmol/L" d_cl_7, "Measured chloride
 concentration in dialysate sample #7 in mmol/L" d_ica_0,
 "Ionized calcium concentration in fresh dialysis fluid (before
 instillation) in mmol/L" d_ica_1, "Measured ionized calcium
 concentration in dialysate sample #1 in mmol/L" d_ica_2,
 "Measured ionized calcium concentration in dialysate sample #2 in
 mmol/L" d_ica_3, "Measured ionized calcium concentration in
 dialysate sample #3 in mmol/L" d_ica_4, "Measured ionized
 calcium concentration in dialysate sample #4 in mmol/L" d_ica_5,
 "Measured ionized calcium concentration in dialysate sample #5 in
 mmol/L" d_ica_6, "Measured ionized calcium concentration in
 dialysate sample #6 in mmol/L" d_ica_7, "Measured ionized
 calcium concentration in dialysate sample #7 in mmol/L" d_tco2_0,
 "Total carbon dioxide concentration in fresh dialysis fluid (before
 instillation) in mmol/L" d_tco2_1, "Measured total carbon
 dioxide concentration in dialysate sample #1 in mmol/L" d_tco2_2,
 "Measured total carbon dioxide concentration in dialysate sample #1
 in mmol/L" d_tco2_3, "Measured total carbon dioxide
 concentration in dialysate sample #1 in mmol/L" d_tco2_4,
 "Measured total carbon dioxide concentration in dialysate sample #1
 in mmol/L" d_tco2_5, "Measured total carbon dioxide
 concentration in dialysate sample #1 in mmol/L" d_tco2_6,
 "Measured total carbon dioxide concentration in dialysate sample #1
 in mmol/L" d_tco2_7, "Measured total carbon dioxide
 concentration in dialysate sample #1 in mmol/L" d_urea_1,
 "Measured urea concentration in dialysate sample #1 in mmol/L"
 d_urea_2, "Measured urea concentration in dialysate sample #2 in
 mmol/L" d_urea_3, "Measured urea concentration in dialysate
 sample #3 in mmol/L" d_urea_4, "Measured urea concentration in
 dialysate sample #4 in mmol/L" d_urea_5, "Measured urea
 concentration in dialysate sample #5 in mmol/L" d_urea_6,
 "Measured urea concentration in dialysate sample #6 in mmol/L"
 d_urea_7, "Measured urea concentration in dialysate sample #7 in
 mmol/L" d_crea_0, "Measured creatinine concentration in fresh
 dialysis fluid (before instillation) in μmol/L" d_crea_1,
 "Measured creatinine concentration in dialysate sample #1 in
 μmol/L" d_crea_2, "Measured creatinine concentration in
 dialysate sample #2 in μmol/L" d_crea_3, "Measured creatinine
 concentration in dialysate sample #3 in μmol/L" d_crea_4,
 "Measured creatinine concentration in dialysate sample #4 in
 μmol/L" d_crea_5, "Measured creatinine concentration in
 dialysate sample #5 in μmol/L" d_crea_6, "Measured creatinine
 concentration in dialysate sample #6 in μmol/L" d_crea_7,
 "Measured creatinine concentration in dialysate sample #7 in
 μmol/L" dt1, "Time point for dialysate sample #1 in minutes post
 start of dialysis" dt2, "Time point for dialysate sample #2 in
 minutes post start of dialysis" dt3, "Time point for dialysate
 sample #3 in minutes post start of dialysis" dt4, "Time point
 for dialysate sample #4 in minutes post start of dialysis" dt5,
 "Time point for dialysate sample #5 in minutes post start of
 dialysis" dt6, "Time point for dialysate sample #6 in minutes
 post start of dialysis" dt7, "Time point for dialysate sample #7
 in minutes post start of dialysis (#8 is same as #7)" d_osm_1,
 "Dialysate osmolarity for sample #1 in mOsm/L" d_osm_7,
 "Dialysate osmolarity for sample #7 in mOsm/L" 1. Missing data
 codes: NA 2. Specialized formats or other abbreviations used: -