cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.20016504.v1
title: Review of main genes and proteins associated with tau-positive frontotemporal dementia

description: This review aimed to present the APOE and MAPT gene and ApoE and tau proteins as genetic markers that have been studied in frontotemporal dementia, which may in future help in the differential diagnosis. Frontotemporal dementia is a neurocognitive disorder characterized by frontal and temporal lobes dysfunction, often associated with atrophy of these structures and relative preservation of posterior brain regions. Clinically, it manifests around 57 years-old, with same incidence in men and women. Frontotemporal dementia has an insidious and progressive onset, with a mild impairment of episodic memory, but with significant behavioral, personality and language changes. Due to possible similarities between the clinical manifestations of dementia including Alzheimer's disease there is a great difficulty in the differential diagnosis, which needs detailed clinical and neuropsychological examination of individuals affected, further biochemical and neuroimaging exams. MAPT gene encodes tau protein, its main function is to stabilize microtubules. In healthy nerve cells, tau protein is usually found in the axons, in contrast to the findings described in neurocognitive disorders in which protein is distributed in the cell body and dendrites. The apolipoprotein E ApoE is a polymorphic glycoprotein, encoded by the APOE gene, which plays an important role in absorption, transport and redistribution of cholesterol, necessary for the repair and maintenance of nervous tissue. Because of increasing life expectancy and birth control, population aging has become fact, bringing a higher prevalence of chronic diseases, so it is extremely important to know more about these dis eases, in order to seek new ways of treating dementias seen that do not have a cure. It is known that the definitive diagnosis of most dementia depends on neuropathological examination, however, with technological advances and techniques of molecular biology and genetics, new opportunities have emerged for the early and differential diagnosis of dementias.
DOI: 10.6084/m9.figshare.20016508
title: Analysis of factors associated to falls and hip fractures in elderly people: a case-control study

description: OBJECTIVE: To identify the main factors associated to falls and hip fractures in the elderly. METHODS: This is a case-control study (a group of cases and two control groups) in a 1: 1: 1 proportion, studying 135 individuals aged ≥60 years, matched by sex, from 2005 to 2012. Data were collected through interviews at the homes of participants, and information was gathered from medical records. To analyze the differences between proportions and means between groups, they employed the chi-square and Student's t test, respectively. To study the association between variables, were performed univariate and multivariate analyzes using logistic regression. As effect measure, were employed odds ratio (OR) and its confidence interval at 95% (95%). In all analyzes, we considered a 5% significance level. RESULTS: After multivariate analysis, hip fracture protection factors were: listen well and have handrails on the stairs of their homes. Risk factors for hip fracture were: hypertension, sedentary lifestyle and have slippery surface in the residence. Protective factors for fall were: have handrails on the stairs of their homes, have osteoporosis and depression. Risk factor for falls was physical inactivity. CONCLUSION: Hip fractures are an important cause of morbidity in the elderly. Knowing the risk factors for post-fall fractures in the elderly is essential for planning individual and collective actions aimed at prevention of this disease and its consequences. Physical activities, more effective treatment plans and inadequacies correction in households of those individuals should be counseled and encouraged.
DOI: 10.6084/m9.figshare.20016508.v1
title: Analysis of factors associated to falls and hip fractures in elderly people: a case-control study

description: OBJECTIVE: To identify the main factors associated to falls and hip fractures in the elderly. METHODS: This is a case-control study (a group of cases and two control groups) in a 1: 1: 1 proportion, studying 135 individuals aged ≥60 years, matched by sex, from 2005 to 2012. Data were collected through interviews at the homes of participants, and information was gathered from medical records. To analyze the differences between proportions and means between groups, they employed the chi-square and Student's t test, respectively. To study the association between variables, were performed univariate and multivariate analyzes using logistic regression. As effect measure, were employed odds ratio (OR) and its confidence interval at 95% (95%). In all analyzes, we considered a 5% significance level. RESULTS: After multivariate analysis, hip fracture protection factors were: listen well and have handrails on the stairs of their homes. Risk factors for hip fracture were: hypertension, sedentary lifestyle and have slippery surface in the residence. Protective factors for fall were: have handrails on the stairs of their homes, have osteoporosis and depression. Risk factor for falls was physical inactivity. CONCLUSION: Hip fractures are an important cause of morbidity in the elderly. Knowing the risk factors for post-fall fractures in the elderly is essential for planning individual and collective actions aimed at prevention of this disease and its consequences. Physical activities, more effective treatment plans and inadequacies correction in households of those individuals should be counseled and encouraged.
DOI: 10.5281/zenodo.6617740
title: Global Functional Genomics Reveals GRK5 as a Therapeutic Target for Cystic Fibrosis

description: Cystic Fibrosis (CF) is a life-shortening disease affecting &gt;90,000 individuals worldwide predominantly with respiratory symptoms. About 80% of individuals with CF have the F508del mutation that causes the CF transmembrane conductance regulator (CFTR) protein to misfold and be targeted for premature degradation by the endoplasmic reticulum (ER) quality control (ERQC), thus preventing its plasma membrane (PM) traffic. Despite the recent approval of a ‘highly effective’ drug rescuing F508del-CFTR, maximal lung function improvement is ~14% and the drug-targeted genes remain unknown. To identify global modulators of F508del traffic, we performed a high-content siRNA microscopy-based screen of &gt;9,000 genes and monitored F508del-CFTR PM rescue in human airway cells. This primary screen identified 227 F508del-CFTR traffic regulators, of which 35 could be validated by additional siRNAs. Subsequent mechanistic studies established GRK5 as a robust regulator whose inhibition rescues F508del-CFTR PM traffic, thus emerging as a novel potential drug target for CF.
description: Image and data analysis of the primary and seconary siRNA screens. Primary screen: CFBE cells expressing mCherry-Flag-F508del-CFTR traffic reporter. Secondary screen: CFBE cells expressing the wt-, F508del- , 4RK-F508del-, G550E-F508el-, R1070W-F508del and DD/AA- variants of the traffic reporter.
DOI: 10.5281/zenodo.6617739
title: Global Functional Genomics Reveals GRK5 as a Therapeutic Target for Cystic Fibrosis

description: Cystic Fibrosis (CF) is a life-shortening disease affecting &gt;90,000 individuals worldwide predominantly with respiratory symptoms. About 80% of individuals with CF have the F508del mutation that causes the CF transmembrane conductance regulator (CFTR) protein to misfold and be targeted for premature degradation by the endoplasmic reticulum (ER) quality control (ERQC), thus preventing its plasma membrane (PM) traffic. Despite the recent approval of a ‘highly effective’ drug rescuing F508del-CFTR, maximal lung function improvement is ~14% and the drug-targeted genes remain unknown. To identify global modulators of F508del traffic, we performed a high-content siRNA microscopy-based screen of &gt;9,000 genes and monitored F508del-CFTR PM rescue in human airway cells. This primary screen identified 227 F508del-CFTR traffic regulators, of which 35 could be validated by additional siRNAs. Subsequent mechanistic studies established GRK5 as a robust regulator whose inhibition rescues F508del-CFTR PM traffic, thus emerging as a novel potential drug target for CF.
description: Image and data analysis of the primary and seconary siRNA screens. Primary screen: CFBE cells expressing mCherry-Flag-F508del-CFTR traffic reporter. Secondary screen: CFBE cells expressing the wt-, F508del- , 4RK-F508del-, G550E-F508el-, R1070W-F508del and DD/AA- variants of the traffic reporter.
DOI: 10.6084/m9.figshare.20016510
title: The performance of elderly's occupational roles with and without depressive symptoms in geriatric monitoring

description: The study aimed to assess if the presence of depressive symptoms could influence the performance of occupational roles in elderly patients in a Geriatric outpatient clinic within a tertiary public hospital. It is a cross-sectional study, comparing groups, and quantitative approach with convenience sampling. Sociodemographic and clinical data based on medical record review and provided by participants were considered, and the instruments Mini Mental State Examination, Geriatric Depression Scale-15, and Occupational Roles ID List were applied. The results showed homogeneity between the groups in terms of sociodemographic and clinical characteristics, and performance of occupational roles, except for the roles of Volunteer and Domestic Services. There were changes in performance between past and present times, with high loss of roles associated with aging and not necessarily depressive symptoms. However, elderly without depressive symptoms group had greater continuity in the Domestic Service role performance, and greater intention to resume the Voluntary role in the future, which was not observed in the group with depressive symptoms. Data shows that the group without depressive symptoms presented best performance for Domestic Service and Volunteer roles, but no difference between groups for the performance standard of other occupational roles.
DOI: 10.6084/m9.figshare.20016510.v1
title: The performance of elderly's occupational roles with and without depressive symptoms in geriatric monitoring

description: The study aimed to assess if the presence of depressive symptoms could influence the performance of occupational roles in elderly patients in a Geriatric outpatient clinic within a tertiary public hospital. It is a cross-sectional study, comparing groups, and quantitative approach with convenience sampling. Sociodemographic and clinical data based on medical record review and provided by participants were considered, and the instruments Mini Mental State Examination, Geriatric Depression Scale-15, and Occupational Roles ID List were applied. The results showed homogeneity between the groups in terms of sociodemographic and clinical characteristics, and performance of occupational roles, except for the roles of Volunteer and Domestic Services. There were changes in performance between past and present times, with high loss of roles associated with aging and not necessarily depressive symptoms. However, elderly without depressive symptoms group had greater continuity in the Domestic Service role performance, and greater intention to resume the Voluntary role in the future, which was not observed in the group with depressive symptoms. Data shows that the group without depressive symptoms presented best performance for Domestic Service and Volunteer roles, but no difference between groups for the performance standard of other occupational roles.
DOI: 10.6084/m9.figshare.20016511
title: Scenery of long-term care institutions: portraits of the routine of a multiprofessional team

description: OBJECTIVE: To identify the challenges and prospects of work in long-term institutions for the elderly (ILPI) in the viewpoint of the multidisciplinary team. METHODOLOGY: Qualitative, exploratory and descriptive study, part of a research entitled "Scenarios of long-term care: evaluative, intervention and educational possibilities in geriatric attention". Research was conducted in the city of Passo Fundo-RS, Brazil, from March to August 2013, involving 14 ILPI's. RESULTS: The challenging situations at work allude to management aspect, systematic actions, maintenance, coexistence and mediation of professional and interpersonal conflicts, as well as to the institutionalization paradigm. The appreciation of professionals based on their insertion in health care settings makes gerontology an emerging specialty with greater encouragement of public power. CONCLUSIONS: The challenges are multiple and of different origins. It is expected that, in the near future, a more homogeneous multidisciplinary team attending current legislation becomes possible.
DOI: 10.6084/m9.figshare.20016511.v1
title: Scenery of long-term care institutions: portraits of the routine of a multiprofessional team

description: OBJECTIVE: To identify the challenges and prospects of work in long-term institutions for the elderly (ILPI) in the viewpoint of the multidisciplinary team. METHODOLOGY: Qualitative, exploratory and descriptive study, part of a research entitled "Scenarios of long-term care: evaluative, intervention and educational possibilities in geriatric attention". Research was conducted in the city of Passo Fundo-RS, Brazil, from March to August 2013, involving 14 ILPI's. RESULTS: The challenging situations at work allude to management aspect, systematic actions, maintenance, coexistence and mediation of professional and interpersonal conflicts, as well as to the institutionalization paradigm. The appreciation of professionals based on their insertion in health care settings makes gerontology an emerging specialty with greater encouragement of public power. CONCLUSIONS: The challenges are multiple and of different origins. It is expected that, in the near future, a more homogeneous multidisciplinary team attending current legislation becomes possible.
DOI: 10.6084/m9.figshare.20016513
title: Sarcopenia: evaluation of different diagnostic criteria and its association with muscle strength and functional capacity

description: INTRODUCTION: Sarcopenia has been associated with increased morbidity and mortality in older people. However, there is still no consensus about the best diagnostic criteria for it. OBJECTIVE: This study aimed to evaluate different diagnostic criteria of sarcopenia and their relationship with muscle strength and functional capacity. METHODS: A cross-sectional study was carried out in Santa Maria-RS, Brazil. Body composition was measured by dual-energy X-ray absorptiometry (DXA). Physical performance was evaluated by the Timed-get-up-and-go test (TGUG). Muscle strength was measured with a handgrip dynamometer. The proposed criteria of sarcopenia were evaluated as follows: A) appendicular lean mass index (aLM/ht2), cutoffs 5.5 kg/m2, 2SD, 10th percentile, and 20th percentile of young reference; B) a linear regression model was used to adjust appendicular lean mass (aLM) for both height and fat mass, cutoff 20th percentile of elderly. RESULTS: In total, 104 women agreed to participate in the research, 39 young (20 to 40 years) and 65 elderly (over 60 years). The prevalence of sarcopenia varied from 0% to 17.2% according to the diagnostic criteria. Regarding muscle strength, the aLM/ht2 cutoff 10th percentile was the criterion with greater area under the ROC curve. However, there were no criteria with an area under the ROC curve greater than 0.5 when TGUG was the outcome. The reclassification showed that the criterion B reclassified 66.7% with normal grip strength as sarcopenic. CONCLUSION: Of these criteria, aLM/ht2 cutoff 10th percentile had stronger correlation with muscle strength.
DOI: 10.6084/m9.figshare.20016514
title: Prevalence of depressive symptoms among elderly in an emergency service

description: OBJECTIVES: To estimate the prevalence of depressive symptoms among elderly patients admitted in the emergency service of Porto Alegre Clinical Hospital, Rio Grande do Sul state, Brazil, and assess the association between depressive symptoms and sociodemographic characteristics and use of health services by the elderly. METHODS: Cross-sectional study of 96 elderly patients admitted to the emergency room. The presence of depressive symptoms was evaluated through the application of the Geriatric Depression Scale - short version (GDS-15), and was applied instrument on sociodemographic variables and use of health services. Descriptive and bivariate analyzes were performed, and statistical significance level was 5% (p≤0.05). RESULTS: We found a prevalence of 36.5% of depressive symptoms in the sample, and of these, 6.3% of the elderly had scores suggestive of severe depression. It identified significant association between depressive symptoms and widowhood, observing that depressive symptoms were more frequent among women, low education and those who did not use health services. CONCLUSION: The study found high prevalence of depressive symptoms among elderly patients admitted in the emergency department. It emphasizes the importance of recognizing and making the diagnosis of depression in the elderly in these services in order to work with a broader view of the health-disease process, provide treatment and better interventions on the network.
DOI: 10.6084/m9.figshare.20016514.v1
title: Prevalence of depressive symptoms among elderly in an emergency service

description: OBJECTIVES: To estimate the prevalence of depressive symptoms among elderly patients admitted in the emergency service of Porto Alegre Clinical Hospital, Rio Grande do Sul state, Brazil, and assess the association between depressive symptoms and sociodemographic characteristics and use of health services by the elderly. METHODS: Cross-sectional study of 96 elderly patients admitted to the emergency room. The presence of depressive symptoms was evaluated through the application of the Geriatric Depression Scale - short version (GDS-15), and was applied instrument on sociodemographic variables and use of health services. Descriptive and bivariate analyzes were performed, and statistical significance level was 5% (p≤0.05). RESULTS: We found a prevalence of 36.5% of depressive symptoms in the sample, and of these, 6.3% of the elderly had scores suggestive of severe depression. It identified significant association between depressive symptoms and widowhood, observing that depressive symptoms were more frequent among women, low education and those who did not use health services. CONCLUSION: The study found high prevalence of depressive symptoms among elderly patients admitted in the emergency department. It emphasizes the importance of recognizing and making the diagnosis of depression in the elderly in these services in order to work with a broader view of the health-disease process, provide treatment and better interventions on the network.
DOI: 10.6084/m9.figshare.20016513.v1
title: Sarcopenia: evaluation of different diagnostic criteria and its association with muscle strength and functional capacity

description: INTRODUCTION: Sarcopenia has been associated with increased morbidity and mortality in older people. However, there is still no consensus about the best diagnostic criteria for it. OBJECTIVE: This study aimed to evaluate different diagnostic criteria of sarcopenia and their relationship with muscle strength and functional capacity. METHODS: A cross-sectional study was carried out in Santa Maria-RS, Brazil. Body composition was measured by dual-energy X-ray absorptiometry (DXA). Physical performance was evaluated by the Timed-get-up-and-go test (TGUG). Muscle strength was measured with a handgrip dynamometer. The proposed criteria of sarcopenia were evaluated as follows: A) appendicular lean mass index (aLM/ht2), cutoffs 5.5 kg/m2, 2SD, 10th percentile, and 20th percentile of young reference; B) a linear regression model was used to adjust appendicular lean mass (aLM) for both height and fat mass, cutoff 20th percentile of elderly. RESULTS: In total, 104 women agreed to participate in the research, 39 young (20 to 40 years) and 65 elderly (over 60 years). The prevalence of sarcopenia varied from 0% to 17.2% according to the diagnostic criteria. Regarding muscle strength, the aLM/ht2 cutoff 10th percentile was the criterion with greater area under the ROC curve. However, there were no criteria with an area under the ROC curve greater than 0.5 when TGUG was the outcome. The reclassification showed that the criterion B reclassified 66.7% with normal grip strength as sarcopenic. CONCLUSION: Of these criteria, aLM/ht2 cutoff 10th percentile had stronger correlation with muscle strength.
DOI: 10.6084/m9.figshare.20016517
title: Influence of nutritional status in the perception of body image and self-steem in elderly woman

description: OBJECTIVE: To investigate the relationship between body mass index, self-esteem and body self-image of elderly participants in groups of seniors. METHODS: Cross-sectional study by casual and unsystematic sampling. Participated in the study 50 elderly residents in the city of João Pessoa-PB. The variables investigated were: sex, age, marital status, income, education and body mass index. The analysis of body image perception was performed using the Nine-figure Outline Scale ( Sorensen & Stunkard). RESULTS: There was no statistical significance between variables. The mean age was 72.12 (6.14). The body mass index had an average of 26.91 kg/m², with overweight observed in 51.02% of this population; most women (90.60%) showed good self-esteem, although half (79.31%) of these were above ideal weight; 87.50% were dissatisfied with their own bodies due to excess weight. CONCLUSION: Although the data did not show statistical significance between the variables, the results suggest that, although most elderly women were overweight, self-esteem showed satisfactory level while the perception of body self-image was unsatisfactory.
DOI: 10.6084/m9.figshare.20016517.v1
title: Influence of nutritional status in the perception of body image and self-steem in elderly woman

description: OBJECTIVE: To investigate the relationship between body mass index, self-esteem and body self-image of elderly participants in groups of seniors. METHODS: Cross-sectional study by casual and unsystematic sampling. Participated in the study 50 elderly residents in the city of João Pessoa-PB. The variables investigated were: sex, age, marital status, income, education and body mass index. The analysis of body image perception was performed using the Nine-figure Outline Scale ( Sorensen & Stunkard). RESULTS: There was no statistical significance between variables. The mean age was 72.12 (6.14). The body mass index had an average of 26.91 kg/m², with overweight observed in 51.02% of this population; most women (90.60%) showed good self-esteem, although half (79.31%) of these were above ideal weight; 87.50% were dissatisfied with their own bodies due to excess weight. CONCLUSION: Although the data did not show statistical significance between the variables, the results suggest that, although most elderly women were overweight, self-esteem showed satisfactory level while the perception of body self-image was unsatisfactory.