cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.58020/nm9d-8192
title: TrialNet 14: Effects of Canakinumab on the Progression of Type 1 Diabetes in New Onset Subjects

description: Canakinumab is a fully human anti-interleukin-1β (anti-IL-1β) monoclonal antibody, designed to bind to human IL-1β and to functionally neutralize the bioactivity of this pro-inflammatory cytokine. In this phase II clinical trial, subjects were randomized to receive either monthly subcutaneous injections of 2.0 mg/kg canakinumab or placebo for 12 months. All subjects received standard intensive diabetes treatment with insulin and dietary management. Diabetes control was evaluated by measuring glycosylated hemoglobin (HbA1c) every three months. Insulin production was measured by a series of mixed meal glucose tolerance tests (MMTT) conducted regularly during the study. Subjects were followed for one year of treatment, plus one to three years of follow-up.
DOI: 10.58020/geaw-2v38
title: TrialNet Pathway To Prevention (formerly Natural History Study)

description: TrialNet is a network of 19 clinical centers worldwide that conducts research on the study, prevention, and early treatment of type 1 diabetes (T1D).  The TrialNet Pathway To Prevention (TN01) is a screening and monitoring study that was established to provide a source of subjects for enrollment into prevention trials. In addition, the prospectively followed cohort is used to gain new insights into the natural history of pre-type 1 diabetes in patients with increased risk for the disease. The primary aim of the study is to identify subjects for TrialNet prevention and investigation trials, but can also be used for assessing the predictive value of existing and novel risk markers of T1D, and for examining the demographic, immunologic, and metabolic characteristics of individuals at risk for developing T1D.

Participants who are unaffected by T1D but who had a family member with TID and hence increased risk for developing the disease are eligible for enrollment. Screened subjects are tested for pancreatic autoantibodies (glutamic acid decarboxylase, insulin, ICA-512) using a blood screening test. Participants with at least one positive tests for any of the antibodies are eligible for confirmatory autoantibody measurements, and metabolic testing including oral glucose tolerance tests (OGTTs). Subjects under age 18 are re-screened annually, and subjects with some risk for disease can be enrolled in prevention trials or followed prospectively.  

Data collected on patients recruited through 2020 are available from the Repository.
DOI: 10.58020/23b5-1q63
title: Trial Of Mid-Urethral Slings

description: Urinary incontinence affects up to 50% of women, resulting in substantial medical, social, and economic burdens. Among U.S. women with urinary incontinence, 15 to 80% have a component of stress incontinence, which results in leakage of urine during physical exertion, sneezing, and coughing. Of these women, 4 to 10% undergo surgery.

TOMUS is a 2-arm, unmasked, multi-center randomized controlled trial that compared two types of mid-urethral slings used for treatment of stress incontinence: the retropubic mid-urethral mesh sling (RMUS) and the transobturator mid-urethral sling (TMUS). RMUS procedures are less invasive than the fascial sling procedures that were reference standards at the start of the study. Specifically, a synthetic tape is passed transvaginally at the midurethral level through the retropubic space. TMUS procedures were developed to minimize the potential for bladder and bowel injuries associated with the retropubic sling, since the sling is passed through the obturator canal, avoiding the pelvic organs in the retropubic space. 

Eligible women 21 years of age or older who were planning to undergo surgery for the treatment of stress incontinence were invited to participate in TOMUS. Randomization was performed after anesthesia was administered. Women were randomly assigned with the use of a permuted-block randomization schedule, with stratification according to clinical site. After the surgery, information regarding the treatment assignment was not kept from the patient. Subjects were followed up at 12 and 24 months after the surgery.

ETOMUS: Women completing 2-year participation in a randomized equivalence trial who had not undergone surgical re-treatment for stress urinary incontinence were invited to participate in a 5-year observational cohort.
DOI: 10.58020/qrdt-eh40
title: Type 1 Diabetes Genetics Consortium

description: The Type 1 Diabetes Genetics Consortium (T1DGC) was an international, multicenter program organized to promote research to identify genes and alleles that determine an individual's risk for type 1 diabetes. The program had two primary goals: (1) to identify genomic regions and candidate genes whose variants modify an individual’s risk of type 1 diabetes and help explain the clustering of the disease in families and (2) to make research data available to and establish resources that can be used by the research community. The T1DGC assembled a resource of affected sib-pair families, parent-child trios, and case-control collections with banks of DNA, serum, plasma, and EBV-transformed cell lines. In addition to T1DGC-recruited ASP families, the T1DGC recruited trio families from ethnic groups with lower prevalence of type 1 diabetes. The T1DGC also welcomed the inclusion of earlier ascertained case-control collections (from the UK, Denmark, etc.). Research with T1DGC data has included genome-wide linkage scans, evaluation of the human major histocompatibility complexes, examination of published candidate genes for type 1 diabetes, and examination of autoimmune disease genes and those affecting β-cell function in type 2 diabetes.

In 2007, the T1DGC incorporated over 7,000 cases from the UK (the JDRF/WT case series, aka GRID). GRID samples are available here, and data from dbGaP, the European Genome-phenome Archive (EGA) and data and documentation at the JDRF/WT DIL.
DOI: 10.58020/f0nt-h716
title: Value of Urodynamic Evaluation

description: Stress urinary incontinence (SUI) is one of two major subtypes of urinary incontinence, a common and costly condition that significantly impairs quality of life of women of all ages. Surgery is one of the most common treatments for SUI. Urodynamic studies (UDS), which assess physiological variables during bladder storage and emptying, are often performed preoperatively to confirm and characterize the clinical features of the condition or to guide decisions about modifications in treatment. Despite common use of UDS, these studies are uncomfortable and costly, increase the risk of urinary tract infection, and their ability to improve surgical outcomes was unkown.

In response to the lack of evidence concerning the utility of UDS, the Value of Urodynamic Evaluation (ValUE) study, a multi-center noninferiority trial was  conducted to compare outcomes among women with SUI who underwent a basic office evaluation without UDS (evaluation-only group) with those among women with SUI who underwent UDS in addition to the office evaluation (urodynamic-testing group) before their planned surgery. Participants with SUI were enrolled from 11 centers nationwide and randomly assigned to a study group. Women in the urodynamic-testing group underwent noninstrumented uroflowmetry with a comfortably full bladder, filling cystometry with Valsalva leak-point pressures, and a pressure-flow study. After interpretation of the urodynamic tests, study physicians again completed the same comprehensive checklist of clinical diagnoses without viewing their previous entries. The primary outcome measure included the Urogential Distress Inventory (UDI), an objective measure that assesses symptoms of incontinence, and the Patient Global Index—Improvement (PGI-I), a patient-reported measure of perceived improvement following treatment. Both measures were assessed at 12 months.
 
Results showed no significant between-group differences in secondary measures of incontinence severity, quality of life, patient satisfaction, rates of positive provocative stress tests, voiding dysfunction, or adverse events. The study concluded that preoperative office evaluation alone was not inferior to evaluation with UDS on outcomes at one year for women with uncomplicated SUI.
DOI: 10.58020/d5sa-x912
title: Viral Resistance to Antiviral Therapy of Chronic Hepatitis C

description: The Viral Resistance to Antiviral Therapy of Chronic Hepatitis C (VIRAHEP-C) study is a multicenter clinical trial designed to test how African Americans respond to antiviral therapy for hepatitis C (HVC) compared to Caucasian patients. Reports of clinical trials for HVC demonstrate markedly worse response in African-American patients than in Caucasian patients with no clear explanation for the difference in outcome. A total of 400 patients, equally divided between African American and Caucasians, were enrolled at eight clinical centers throughout the United States. All participants were HCV genotype 1. Participants were treated for 48 weeks with pegylated interferon alfa-2a (180 mcg/week) plus ribavirin (1000-1200mg/day). Participants were followed for an additional 48 weeks after cessation of therapy. Sustained virological response rates (undetectable HCV RNA in serum 24 weeks post-treatment) and durable sustained virological response rates (undetectable HCV RNA in serum 48 weeks post-treatment) between the two cohorts were compared to determine differences in treatment response between the two racial groups. Results showed that African Americans with chronic hepatitis C genotype 1 have lower rates of virologic response to pegylated interferon and ribavirin than Caucasian Americans, as hypothesized. Factors contributing to the differences in response between the groups remain unclear.
DOI: 10.5066/p9n97bdi
title: Daily Nooksack River Basin Nutrient Loading Estimates from 2018 to 2021

description: The Nooksack River watershed comprises the majority of the Water Resources Inventory Area 1 (WRIA 1) located in Whatcom County in Washington State. From its headwaters in the northwestern Cascade Mountains, the Nooksack River drains approximately 809 square miles, comprising most of western Whatcom County, including agricultural areas and the developed lowlands surrounding the towns of Deming, Everson, Lynden, and Ferndale. The Nooksack River enters the Lummi Indian Reservation at its eastern extent, which contains the majority of the Nooksack River delta before it discharges into the marine waters of Bellingham Bay. The Nooksack River is also the primary source of freshwater into Portage Bay, which is located approximately 5 miles southwest of the Nooksack River delta. Continuous nitrate monitoring data were collected at three sites in the Nooksack Basin. The first site, located on Fishtrap Creek near Lynden, WA (USGS site ID 12212050), is a tributary to the Nooksack River. This site is influenced by nearby farmland/agricultural land runoff making it an important location for monitoring nutrient loads into the main stem of the Nooksack River. Data were collected from April 28, 2018 to December 31, 2021. At a second tributary site, Kamm Creek near Lynden, WA (USGS site ID 12211390), data were collected from October 7, 2019 to December 31, 2021. Lastly, the third site was located at the mouth of the Nooksack River at Ferndale, WA (USGS site ID 12213100) from March 30, 2019 to December 31, 2021. Existing USGS stationgages at the Nooksack at Ferndale and Fishtrap Creek near Lynden allow for the computation of nitrate estimated loads during the monitoring period. The daily nitrate estimated loads data provided in this data release are computed using approved USGS nitrate concentrations and river discharge. There is not a discharge record at Kamm creek, and therefore only approved nitrate concentration data is available via the National Water Information System (NWIS - https://waterdata.usgs.gov/nwis).
DOI: 10.6073/pasta/2c3731e00e8fb1b2339c76e2c9e6b543
title: Time-series of high-frequency profiles of fluorescence-based phytoplankton spectral groups in Beaverdam Reservoir, Carvins Cove Reservoir, Falling Creek Reservoir, Gatewood Reservoir, and Spring Hollow Reservoir in southwestern Virginia, USA 2014-2022

description: Depth profiles of fluorescence-based phytoplankton biomass were sampled using a bbe Moldaenke FluoroProbe during 2014 to 2022 in five drinking water reservoirs in southwestern Virginia, USA. These reservoirs are: Beaverdam Reservoir (Vinton, Virginia), Carvins Cove Reservoir (Roanoke, Virginia), Falling Creek Reservoir (Vinton, Virginia), Gatewood Reservoir (Pulaski, Virginia), and Spring Hollow Reservoir (Salem, Virginia). Beaverdam, Carvins Cove, Falling Creek, and Spring Hollow Reservoirs are owned and operated by the Western Virginia Water Authority as primary or secondary drinking water sources for Roanoke, Virginia, and Gatewood Reservoir is a drinking water source for the town of Pulaski, Virginia. The dataset consists of depth profiles of fluorescence-based phytoplankton biomass measured at the deepest site of each reservoir adjacent to the dam, except in Falling Creek Reservoir, where depth profiles were also taken at four upstream sites ranging from the riverine to the lacustrine zone during 2016-2019. Casts were taken approximately weekly from May-October and monthly from November-April. Casts were collected at Beaverdam and Falling Creek Reservoirs during all years (2014-2022); casts were collected at Carvins Cove Reservoir during 2014-2016 and 2018-2022; casts were collected at Spring Hollow Reservoir during 2014-2016 and 2019; and casts were collected at Gatewood Reservoir in 2015-2016.
DOI: 10.5281/zenodo.7535143
title: [IO Islamic 1667] خمسۀ نظامى

description: <strong>Khamsa-i-Niżâmî.</strong> <strong>This manuscript is now IO Islamic 975 in the India Office collections.</strong> <strong>[metadata:</strong> <strong>Hermann Ethé</strong><strong><em>, </em></strong><strong><em>Catalogue of Persian Manuscripts in the Library of the India Office,</em></strong> <strong>2 vols. (Oxford: India Office, 1903): volume 1,</strong> <strong>number 1667 here with notations and hyperlinks].</strong> 975 The same. Contents: 1.Makhzan-alasrâr, on fol. 1<sup>b</sup>. 2. Haft Paikar, on fol. 24<sup>b</sup>. 3. Khusrau u Shîrîn, on fol. 73<sup>b</sup>. 4. Lailâ u Majnûn, on fol. 142<sup>b</sup>. 5<sup>a</sup>. The <em>first</em> part of the Iskandarnâma, styled اقبالنامۀ اسكندرى, on fol. 184<sup>b</sup>. 5<sup>b</sup>. The <em>second </em>part of the Iskandarnâma, styled here اقبالنامۀ شيخ نظامى, on fol. 250<sup>b</sup>. A few lines on fol. 269<sup>a</sup> are left blank. This copy, worm-eaten in many places, was finished in Rajab, A.H. 1054 (A.D. 1644, September), by Muḥammad Riḍâ. No. 1667, ff. 285, 4 coll., each ll. 25; small Nasta’lîḳ; an illuminated frontispiece at the beginning of each mathnawî, the first two pages of each are besides splendidly adorned; size, 10¼ in. by 5 in.
DOI: 10.5281/zenodo.7535142
title: [IO Islamic 1667] خمسۀ نظامى

description: <strong>Khamsa-i-Niżâmî.</strong> <strong>This manuscript is now IO Islamic 975 in the India Office collections.</strong> <strong>[metadata:</strong> <strong>Hermann Ethé</strong><strong><em>, </em></strong><strong><em>Catalogue of Persian Manuscripts in the Library of the India Office,</em></strong> <strong>2 vols. (Oxford: India Office, 1903): volume 1,</strong> <strong>number 1667 here with notations and hyperlinks].</strong> 975 The same. Contents: 1.Makhzan-alasrâr, on fol. 1<sup>b</sup>. 2. Haft Paikar, on fol. 24<sup>b</sup>. 3. Khusrau u Shîrîn, on fol. 73<sup>b</sup>. 4. Lailâ u Majnûn, on fol. 142<sup>b</sup>. 5<sup>a</sup>. The <em>first</em> part of the Iskandarnâma, styled اقبالنامۀ اسكندرى, on fol. 184<sup>b</sup>. 5<sup>b</sup>. The <em>second </em>part of the Iskandarnâma, styled here اقبالنامۀ شيخ نظامى, on fol. 250<sup>b</sup>. A few lines on fol. 269<sup>a</sup> are left blank. This copy, worm-eaten in many places, was finished in Rajab, A.H. 1054 (A.D. 1644, September), by Muḥammad Riḍâ. No. 1667, ff. 285, 4 coll., each ll. 25; small Nasta’lîḳ; an illuminated frontispiece at the beginning of each mathnawî, the first two pages of each are besides splendidly adorned; size, 10¼ in. by 5 in.
DOI: 10.25824/redu/4hrixq
title: Instrumento adaptado para coleta de dados.tab
DOI: 10.25824/redu/d9cfat
title: Tabulação de dados EGA.tab
DOI: 10.25824/redu/5ndwlc
title: Resultado juizes.docx
DOI: 10.25824/redu/5s5jjr
title: Cópia de Dados final.xlsx
DOI: 10.25824/redu/2fk4zg
title: Instrumento para tabulação EGA.tab
DOI: 10.25824/redu/pbgqba
title: Tabulação de dados - EGA clínica e vascular.tab
DOI: 10.25824/redu/pgytv5
title: Replication data for:

description: Content validity index Patient Classification
DOI: 10.6073/pasta/72ac18196692fe9e0d433d755e66374d
title: PIE LTER salt marsh vegetation cover data from regularly monitored quadrats along transects in Rowley, MA.

description: Marsh vegetation cover data from quadrats along transects in salt marsh sites in Rowley, MA. The transects are intended to study long term changes in marsh vegetation. Four sites ((12 transects) were originally set up to study the impact of salt marsh haying. Two of these sites (labeled McH and EPH) were regularly hayed until 2002. The other two (PUH and CC) were reference sites. Two additional sites labeled RM and RR (8 transects) were originally set up to track invasion by Phragmites australis.
DOI: 10.5281/zenodo.7535180
title: [IO Islamic 387] خمسۀ نظامى

description: <strong>Khamsa-i-Niżâmî.</strong> <strong>This manuscript is now IO Islamic 976 in the India Office collections.</strong> <strong>[metadata:</strong> <strong>Hermann Ethé</strong><strong><em>, </em></strong><strong><em>Catalogue of Persian Manuscripts in the Library of the India Office,</em></strong> <strong>2 vols. (Oxford: India Office, 1903): volume 1,</strong> <strong>number 387 here with notations and hyperlinks].</strong> 976 The same. Contents: 1.Makhzan-alasrâr, on fol. 1<sup>b</sup>. 2. Khusra u Shîrîn, on fol. 37<sup>b</sup>. 3. Lailâ u Majnûn, on fol. 141<sup>b</sup>. 4. Haft Paikar, on fol. 212<sup>b</sup>. 5<sup>a</sup>.The <em>first</em> part of the Iskandarnâma (اقبالنامۀ اسكندرى), on fol. 293<sup>b</sup>. 5<sup>b</sup>. The <em>second</em> part of the Iskandarnâma (خردنامۀ اسكندرى), on fol. 400<sup>b</sup>. The copy concludes on fol. 454<sup>b</sup>, and on ff. 455-468 some parts of the last mathnawî are repeated, but not in any coherent form; for instance, fol. 456<sup>b</sup>, l. 11, corresponds to fol. 433<sup>a</sup>, l. 3, but the preceding portions in both parts are quite different. On fol. 453<sup>a</sup>, l. 5, there appears the وفات حكيم , i.e. the انجامش روزگار نظامى, see above in No. 973. No date. But on fol. 1<sup>a</sup> there is the seal of a former owner, rather effaced, dated A.H. 1070 (A.D. 1659, 1660), and another of Shâh Mîrkhân (dated A.H. 1147. A.D. 1734, 1735). In August, 1782, this MS. came into the possession of Mr. Richard Johnson. No. 387, ff. 468, 4 centre-coll., each ll. 17; beautiful Nasta’lîḳ; an illuminated frontispiece at the beginning of each mathnawî, the first two pages luxuriously adorned; a vignette on fol. 1<sup>a</sup>; miniature paintings on ff. 4<sup>a</sup>, 17<sup>a</sup>, 47<sup>b</sup>, 55<sup>a</sup>, 61<sup>b</sup>, 64<sup>a</sup>, 65<sup>b</sup>, 70<sup>a</sup>, 71<sup>b</sup>, 83<sup>a</sup>, 93<sup>b</sup>, 95<sup>b</sup>, 102<sup>b</sup>, 104<sup>a</sup>, 124<sup>a</sup>, 132<sup>a</sup>, 167<sup>b</sup>, 182<sup>a</sup>, 201<sup>b</sup>, 225<sup>b</sup>, 227<sup>a</sup>, 232<sup>a</sup>, 235<sup>b</sup>, 237<sup>b</sup>, 244<sup>a</sup>, 252<sup>a</sup>, 259<sup>b</sup>, 264<sup>b</sup>, 267<sup>a</sup>, 279<sup>a</sup>, 284<sup>b</sup>, 306<sup>b</sup>, 311<sup>a</sup>, 318<sup>a</sup>, 334<sup>a</sup>, 337<sup>b</sup>, 346<sup>b</sup>, 364<sup>b</sup>, 372<sup>b</sup>, 374<sup>a</sup>, 386<sup>a</sup>, 396<sup>a</sup>, 422<sup>b</sup>, 438<sup>a</sup>, 442<sup>b</sup>, 456<sup>a</sup>, 466<sup>a</sup>, and 468<sup>a</sup>; size, 10½ in. by 6½ in.
DOI: 10.5281/zenodo.7535179
title: [IO Islamic 387] خمسۀ نظامى

description: <strong>Khamsa-i-Niżâmî.</strong> <strong>This manuscript is now IO Islamic 976 in the India Office collections.</strong> <strong>[metadata:</strong> <strong>Hermann Ethé</strong><strong><em>, </em></strong><strong><em>Catalogue of Persian Manuscripts in the Library of the India Office,</em></strong> <strong>2 vols. (Oxford: India Office, 1903): volume 1,</strong> <strong>number 387 here with notations and hyperlinks].</strong> 976 The same. Contents: 1.Makhzan-alasrâr, on fol. 1<sup>b</sup>. 2. Khusra u Shîrîn, on fol. 37<sup>b</sup>. 3. Lailâ u Majnûn, on fol. 141<sup>b</sup>. 4. Haft Paikar, on fol. 212<sup>b</sup>. 5<sup>a</sup>.The <em>first</em> part of the Iskandarnâma (اقبالنامۀ اسكندرى), on fol. 293<sup>b</sup>. 5<sup>b</sup>. The <em>second</em> part of the Iskandarnâma (خردنامۀ اسكندرى), on fol. 400<sup>b</sup>. The copy concludes on fol. 454<sup>b</sup>, and on ff. 455-468 some parts of the last mathnawî are repeated, but not in any coherent form; for instance, fol. 456<sup>b</sup>, l. 11, corresponds to fol. 433<sup>a</sup>, l. 3, but the preceding portions in both parts are quite different. On fol. 453<sup>a</sup>, l. 5, there appears the وفات حكيم , i.e. the انجامش روزگار نظامى, see above in No. 973. No date. But on fol. 1<sup>a</sup> there is the seal of a former owner, rather effaced, dated A.H. 1070 (A.D. 1659, 1660), and another of Shâh Mîrkhân (dated A.H. 1147. A.D. 1734, 1735). In August, 1782, this MS. came into the possession of Mr. Richard Johnson. No. 387, ff. 468, 4 centre-coll., each ll. 17; beautiful Nasta’lîḳ; an illuminated frontispiece at the beginning of each mathnawî, the first two pages luxuriously adorned; a vignette on fol. 1<sup>a</sup>; miniature paintings on ff. 4<sup>a</sup>, 17<sup>a</sup>, 47<sup>b</sup>, 55<sup>a</sup>, 61<sup>b</sup>, 64<sup>a</sup>, 65<sup>b</sup>, 70<sup>a</sup>, 71<sup>b</sup>, 83<sup>a</sup>, 93<sup>b</sup>, 95<sup>b</sup>, 102<sup>b</sup>, 104<sup>a</sup>, 124<sup>a</sup>, 132<sup>a</sup>, 167<sup>b</sup>, 182<sup>a</sup>, 201<sup>b</sup>, 225<sup>b</sup>, 227<sup>a</sup>, 232<sup>a</sup>, 235<sup>b</sup>, 237<sup>b</sup>, 244<sup>a</sup>, 252<sup>a</sup>, 259<sup>b</sup>, 264<sup>b</sup>, 267<sup>a</sup>, 279<sup>a</sup>, 284<sup>b</sup>, 306<sup>b</sup>, 311<sup>a</sup>, 318<sup>a</sup>, 334<sup>a</sup>, 337<sup>b</sup>, 346<sup>b</sup>, 364<sup>b</sup>, 372<sup>b</sup>, 374<sup>a</sup>, 386<sup>a</sup>, 396<sup>a</sup>, 422<sup>b</sup>, 438<sup>a</sup>, 442<sup>b</sup>, 456<sup>a</sup>, 466<sup>a</sup>, and 468<sup>a</sup>; size, 10½ in. by 6½ in.
DOI: 10.6084/m9.figshare.21898911
title: Data Delestrain NKX2-1

description: Data from Deciphering an unexpected, isolated lung phenotype of NKX2-1 frameshift mutation" (10.3389/fped.2022.978598)
DOI: 10.6084/m9.figshare.21898911.v1
title: Data Delestrain NKX2-1

description: Data from Deciphering an unexpected, isolated lung phenotype of NKX2-1 frameshift mutation" (10.3389/fped.2022.978598)
DOI: 10.6073/pasta/701a11683a838018a0b12a4f2ba20b5c
title: PIE LTER salt marsh vegetation frequency of occurrence from regularly monitored transects in Rowley, MA

description: Marsh vegetation presence-absence data along transects in salt marsh sites in Rowley, MA. The transects are intended to study long term changes in marsh vegetation. Four sites ((12 transects) were originally set up to study the impact of salt marsh haying. Two of these sites (labeled McH and EPH) were regularly hayed until 2002. The other two (PUH and CC) were reference sites. Two additional sites labeled RM and RR (8 transects) were originally set up to track invasion by Phragmites australis.