DOI: 10.5061/dryad.9kd51c5s9
title: Data from: Changes in brain structure and function following exposure to oral LSD during adolescence: A multimodal MRI study

description: Background: LSD  is a hallucinogen with complex neurobiological
 and behavioral effects.  Underlying these effects are changes in
 brain neuroplasticity. This is the first study to follow the developmental
 changes in brain structure and function following LSD exposure in
 periadolescence.  We hypothesized LSD given during a time of
 heightened neuroplasticity, particularly in the forebrain, would affect
 cognitive and emotional behavior and the associated underlying
 neuroanatomy and neurocircuitry.    Methods: Female and
 male mice were given vehicle, single, or multiple treatments of 3.3 µg of
 LSD by oral gavage starting on postnatal day 51. Between postnatal days
 90-120 mice were imaged and tested for cognitive and motor behavior. MRI
 data from voxel-based morphometry, diffusion weighted imaging, and BOLD
 resting state functional connectivity were registered to a mouse 3D MRI
 atlas with 139 brain regions providing site-specific differences in global
 brain structure and functional connectivity between experimental groups.
 Results: Motor behavior and cognitive performance were unaffected by
 periadolescent exposure to LSD. Differences across experimental groups in
 brain volume for any of the 139 brain areas were few in number and not
 focused on any specific brain region. Multiple exposures to LSD
 significantly altered gray matter microarchitecture across much of the
 brain. These changes were primary associated with the thalamus, sensory
 and motor cortices, and basal ganglia. The forebrain olfactory system and
 prefrontal cortex and hindbrain cerebellum and brainstem were unaffected.
 The functional connectivity between forebrain white matter tracts and
 sensorimotor cortices and hippocampus was reduced with multidose LSD
 exposure. Conclusion: Does early exposure to LSD in periadolescence have
 lasting effects on brain development? There was no evidence of LSD having
 consequential effects on cognitive or motor behavior when animal were
 evaluated as young adults 90-120 days of age.   Neither
 were there any differences in the volume of specific brain areas between
 experimental conditions. The pronounced changes in indices of anisotropy
 across much of the brain would suggest altered gray matter
 microarchitecture and neuroplasticity. The reduction in connectivity in
 forebrain white matter tracts with multidose LSD and consolidation around
 sensorimotor and hippocampal brain areas requires a battery of tests to
 understand the consequences of these changes on behavior.
description: Female and male mice were given vehicle, single or multiple
 treatments of 3.3 µg of LSD by oral gavage starting on postnatal day 51.
 Between postnatal days 90-120 mice were imaged and tested for cognitive
 and motor behavior. MRI data from voxel-based morphometry, diffusion
 weighted imaging, and BOLD resting state functional connectivity were
 registered to a mouse 3D MRI atlas with 139 brain regions providing
 site-specific differences in global brain structure and functional
 connectivity between experimental groups.
description: # Changes in brain structure and function following exposure to oral LSD
 during adolescence: A multimodal MRI study
 [https://doi.org/10.5061/dryad.9kd51c5s9](https://doi.org/10.5061/dryad.9kd51c5s9) Methods: Female and male mice were given vehicle, single or multiple treatments of 3.3 µg of LSD by oral gavage starting on postnatal day 51. Between postnatal days 90-120 mice were imaged and tested for cognitive and motor behavior. MRI data from voxel-based morphometry, diffusion weighted imaging, and BOLD resting state functional connectivity were registered to a mouse 3D MRI atlas with 139 brain regions providing site-specific differences in global brain structure and functional connectivity between experimental groups. ## Data: This is Resting state functional connectivity data. The three groups, Vehicle, Single-Dose, and Multi-Dose, consist of a total of 34 scans. Below is a description of the IDs: * Vehicle - 11 scans, labeled: "B#_V#m/f" * Single-Dose - 12 scans, labeled: "B#_S#m/f" * Multi-Dose - 11 scans, labeled: "B#_M#m/f" where * B# is Batch number animal belong to. * V :Vehicle * S :Single-Dose * M :Multi-Dose * m/f: male or female