cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.5517/ccdc.csd.cc269sz9
title: CCDC 2035211: Experimental Crystal Structure Determination

description: Related Article: Josiéli Demetrio Siqueira, Sidnei Flores de Pellegrin, Liniquer André Fontana, Bernardo Almeida Iglesias, Michele Rorato Sagrillo, Pâmella Schramm Oliveira, Aline Rossato, Larissa Da Silva Silveira, Ademir Neves, Otávio Augusto Chaves, Davi Fernando Back|2021|Inorg.Chim.Acta|526|120530|doi:10.1016/j.ica.2021.120530
DOI: 10.5517/ccdc.csd.cc26vmk8
title: CCDC 2051380: Experimental Crystal Structure Determination

description: Related Article: Hiroki Hayashi, Hideaki Takano, Hitomi Katsuyama, Yu Harabuchi, Satoshi Maeda, Tsuyoshi Mita|2021|Chem.-Eur.J.|27|10040|doi:10.1002/chem.202100812
DOI: 10.5517/ccdc.csd.cc26vml9
title: CCDC 2051381: Experimental Crystal Structure Determination

description: Related Article: Hiroki Hayashi, Hideaki Takano, Hitomi Katsuyama, Yu Harabuchi, Satoshi Maeda, Tsuyoshi Mita|2021|Chem.-Eur.J.|27|10040|doi:10.1002/chem.202100812
DOI: 10.5517/ccdc.csd.cc26vmmb
title: CCDC 2051382: Experimental Crystal Structure Determination

description: Related Article: Hiroki Hayashi, Hideaki Takano, Hitomi Katsuyama, Yu Harabuchi, Satoshi Maeda, Tsuyoshi Mita|2021|Chem.-Eur.J.|27|10040|doi:10.1002/chem.202100812
DOI: 10.5517/ccdc.csd.cc26zrvt
title: CCDC 2055357: Experimental Crystal Structure Determination

description: Related Article: Brenna K. Collins, Melissa Clough Mastry, Andreas Ehnbom, Nattamai Bhuvanesh, Michael B. Hall, John A. Gladysz|2021|Chem.-Eur.J.|27|10021|doi:10.1002/chem.202100305
DOI: 10.5517/ccdc.csd.cc270yz6
title: CCDC 2056508: Experimental Crystal Structure Determination

description: Related Article: Brenna K. Collins, Melissa Clough Mastry, Andreas Ehnbom, Nattamai Bhuvanesh, Michael B. Hall, John A. Gladysz|2021|Chem.-Eur.J.|27|10021|doi:10.1002/chem.202100305
DOI: 10.5517/ccdc.csd.cc271v9g
title: CCDC 2057355: Experimental Crystal Structure Determination

description: Related Article: Brenna K. Collins, Melissa Clough Mastry, Andreas Ehnbom, Nattamai Bhuvanesh, Michael B. Hall, John A. Gladysz|2021|Chem.-Eur.J.|27|10021|doi:10.1002/chem.202100305
DOI: 10.5517/ccdc.csd.cc271vbh
title: CCDC 2057356: Experimental Crystal Structure Determination

description: Related Article: Brenna K. Collins, Melissa Clough Mastry, Andreas Ehnbom, Nattamai Bhuvanesh, Michael B. Hall, John A. Gladysz|2021|Chem.-Eur.J.|27|10021|doi:10.1002/chem.202100305
DOI: 10.5517/ccdc.csd.cc2725p6
title: CCDC 2057677: Experimental Crystal Structure Determination

description: Related Article: Hiroki Hayashi, Hideaki Takano, Hitomi Katsuyama, Yu Harabuchi, Satoshi Maeda, Tsuyoshi Mita|2021|Chem.-Eur.J.|27|10040|doi:10.1002/chem.202100812
DOI: 10.5517/ccdc.csd.cc2725r8
title: CCDC 2057679: Experimental Crystal Structure Determination

description: Related Article: Hiroki Hayashi, Hideaki Takano, Hitomi Katsuyama, Yu Harabuchi, Satoshi Maeda, Tsuyoshi Mita|2021|Chem.-Eur.J.|27|10040|doi:10.1002/chem.202100812
DOI: 10.5517/ccdc.csd.cc272lmk
title: CCDC 2058078: Experimental Crystal Structure Determination

description: Related Article: Victor Brosius, Svenja Weigold, Nikolai Hippchen, Frank Rominger, Jan Freudenberg, Uwe H. F. Bunz|2021|Chem.-Eur.J.|27|10001|doi:10.1002/chem.202100372
DOI: 10.5517/ccdc.csd.cc272lnl
title: CCDC 2058079: Experimental Crystal Structure Determination

description: Related Article: Victor Brosius, Svenja Weigold, Nikolai Hippchen, Frank Rominger, Jan Freudenberg, Uwe H. F. Bunz|2021|Chem.-Eur.J.|27|10001|doi:10.1002/chem.202100372
DOI: 10.5517/ccdc.csd.cc272lpm
title: CCDC 2058080: Experimental Crystal Structure Determination

description: Related Article: Victor Brosius, Svenja Weigold, Nikolai Hippchen, Frank Rominger, Jan Freudenberg, Uwe H. F. Bunz|2021|Chem.-Eur.J.|27|10001|doi:10.1002/chem.202100372
DOI: 10.5517/ccdc.csd.cc27380n
title: CCDC 2058710: Experimental Crystal Structure Determination

description: Related Article: Ming Zhang, Xiao-Chen Wang|2021|Angew.Chem.,Int.Ed.|60|17185|doi:10.1002/anie.202106168
DOI: 10.5517/ccdc.csd.cc27382q
title: CCDC 2058712: Experimental Crystal Structure Determination

description: Related Article: Ming Zhang, Xiao-Chen Wang|2021|Angew.Chem.,Int.Ed.|60|17185|doi:10.1002/anie.202106168
DOI: 10.5517/ccdc.csd.cc27mcv3
title: CCDC 2074205: Experimental Crystal Structure Determination

description: Related Article: Prabhakaran Rajasekar, Abinash Swain, Gopalan Rajaraman, Ramamoorthy Boomishankar|2021|Chem.-Eur.J.|27|10012|doi:10.1002/chem.202101239
DOI: 10.5517/ccdc.csd.cc27mcw4
title: CCDC 2074206: Experimental Crystal Structure Determination

description: Related Article: Prabhakaran Rajasekar, Abinash Swain, Gopalan Rajaraman, Ramamoorthy Boomishankar|2021|Chem.-Eur.J.|27|10012|doi:10.1002/chem.202101239
DOI: 10.5517/ccdc.csd.cc280d7y
title: CCDC 2085749: Experimental Crystal Structure Determination

description: Related Article: Téo Hebra, Nicolas Elie, Salomé Poyer, Elsa Van Elslande, David Touboul, Véronique Eparvier|2021|Metabolites|11|444|doi:10.3390/metabo11070444
DOI: 10.5517/ccdc.csd.cc280d8z
title: CCDC 2085750: Experimental Crystal Structure Determination

description: Related Article: Téo Hebra, Nicolas Elie, Salomé Poyer, Elsa Van Elslande, David Touboul, Véronique Eparvier|2021|Metabolites|11|444|doi:10.3390/metabo11070444
DOI: 10.6084/m9.figshare.15073869
title: Figure_4

description: Data to generate Figure 4
DOI: 10.6084/m9.figshare.15073869.v1
title: Figure_4

description: Data to generate Figure 4
DOI: 10.6084/m9.figshare.15073881
title: Figure_5

description: Data to generate Figure 5
DOI: 10.6084/m9.figshare.15073881.v1
title: Figure_5

description: Data to generate Figure 5
DOI: 10.6084/m9.figshare.15073887
title: Figure S1

description: Figure S1
DOI: 10.6084/m9.figshare.15073887.v1
title: Figure S1

description: Figure S1
DOI: 10.6084/m9.figshare.15073893
title: Figure_S2

description: Figure S2
DOI: 10.6084/m9.figshare.15073893.v1
title: Figure_S2

description: Figure S2
DOI: 10.6084/m9.figshare.15073896.v1
title: Figure_S3

description: Figure S3
DOI: 10.6084/m9.figshare.15073896
title: Figure_S3

description: Figure S3
DOI: 10.6084/m9.figshare.15073902
title: Figure_S4

description: Figure S4
DOI: 10.6084/m9.figshare.15073902.v1
title: Figure_S4

description: Figure S4
DOI: 10.6084/m9.figshare.15073905
title: Figure_S5

description: Figure_S5
DOI: 10.6084/m9.figshare.15073905.v1
title: Figure_S5

description: Figure_S5
DOI: 10.34808/ydsj-x641
title: Data from the survey on the opinion of Gdańsk University of Technology foreign graduates – additional comments

description: The dataset includes additional comments from the survey on the opinion of Gdańsk University of Technology foreign graduates. The research was conducted over four months, from December 2019 to March 2020, using the Computer-Assisted Web Interview (CAWI). The research sample included 142 respondents. Summarizing, among the additional comments to the study, positive opinions about studying in GdanskTech prevailed overwhelmingly.
DOI: 10.5281/zenodo.5101215
title: Endogenous 17O DNP of Gd-Doped CeO2 from 100 to 370 K

description: Raw and processed 17O NMR and DNP-enhanced NMR spectra, and EPR spectra, for Gd-doped CeO2 with Gd concentrations from 0.01 atom% to 1 atom%, as presented in the publication "Endogenous 17O DNP of Gd-Doped CeO2 from 100 to 370 K". NMR data is given in the JCAMP-DX 6.0 format. The TopSpin software is recommended as this was used to record the NMR data. See the README file for more details.
DOI: 10.14457/cu.the.1987.166
title: วรรณกรรมประเภทกลอนสวดภาคกลาง : การศึกษาเชิงวิเคราะห์
DOI: 10.14457/cu.the.1987.167
title: การนำประสบการณ์จากการเรียนกลุ่มการงานและพื้นฐานอาชีพไปใช้ในชีวิตประจำวันของผู้สำเร็จการศึกษาระดับประถมศึกษา ที่ไม่ศึกษาต่อจังหวัดนครราชสีมา
DOI: 10.34740/kaggle/dsv/2476454
title: 2021 World Population (updated daily)
DOI: 10.5281/zenodo.5137613
title: D-GIN dataset, config and model weight files

description: the dataset, configuration and model weight files to reproduce the results of the '<strong>Improved lipophilicity and aqueous solubility prediction using composite graph neural networks</strong>' manuscript.
DOI: 10.5281/zenodo.5137612
title: D-GIN dataset, config and model weight files

description: the dataset, configuration and model weight files to reproduce the results of the '<strong>Improved lipophilicity and aqueous solubility prediction using composite graph neural networks</strong>' manuscript.
DOI: 10.6084/m9.figshare.15073920
title: The fasta clean data

description: the celan dataset of 16S rRNA gene sequences
DOI: 10.6084/m9.figshare.12376766
title: Data and Codes

description: The dataset and codes for generating GEOTask.
DOI: 10.6084/m9.figshare.12376766.v3
title: Data and Codes

description: The dataset and codes for generating GEOTask.
DOI: 10.6084/m9.figshare.12376766.v2
title: Data and Codes

description: The dataset and codes for generating GEOTask, and the source codes of GEOTask Viz are also provided.
DOI: 10.5281/zenodo.5145859
title: Data for "Photoluminescence tells us about voltages, recombination and diode factors in solar cells"

description: Detailed description in "Photoluminescence tells us about voltages, recombination and diode factors in solar cells" by Susanne Siebentritt, Thomas Paul Weiss, Mohit Sood, Max Hilaire Wolter, Alberto Lomuscio, Omar Ramirez submitted to J. Phys. Materials
DOI: 10.5281/zenodo.5145858
title: Data for "Photoluminescence tells us about voltages, recombination and diode factors in solar cells"

description: Detailed description in "Photoluminescence tells us about voltages, recombination and diode factors in solar cells" by Susanne Siebentritt, Thomas Paul Weiss, Mohit Sood, Max Hilaire Wolter, Alberto Lomuscio, Omar Ramirez submitted to J. Phys. Materials
DOI: 10.34740/kaggle/dsv/2476489
title: YouTube Trending Video Dataset (updated daily)
DOI: 10.6073/pasta/8e800943796dcb89caaac3aa02b62fad
title: Stratified Vegetation Survey Data from an Experimental Mangrove Site in Port Aransas, Texas: 2019

description: We visually surveyed the vegetation at the front and back of ten large experimental plots located in a large stand of mangroves near Port Aransas, Texas on November 28th, 2019. The ten experimental plots had been thinned using a 3 x 3 m grid in 2012 to create a gradient in plot-level mangrove cover from 0 to 100 percent. We estimated percent cover in six “mangrove” and six “cleared” cells at the front and back of each plot.
DOI: 10.5523/bris.bnqqyngt89eo26qk8keckglww
title: ICESat-2-derived grounding zone product for Antarctica

description: This data set provides a comprehensive Antarctic grounding zone mapping, including the landward limit of tidal flexure, the inshore limit of hydrostatic equilibrium and the break-in-slope, based on the Ice, Cloud, and land Elevation Satellite 2 (ICESat-2) laser altimetry ATL06 Land Ice Height product acquired between March 2019 and September 2020. The grounding zone estimates were derived from automated techniques using ICESat-2 repeat tracks.
DOI: 10.6084/m9.figshare.15074070
title: Santana et al_ESM, data & code from Fruit odorants mediate co-specialization in a multispecies plant–animal mutualism

description: Methods details, supplementary figures and tables, data files and R code used in analyses
DOI: 10.6073/pasta/1f509991c1924398ac8957b850fe9c14
title: Effect of mangroves on transplanted marsh plants, Port Aransas, Texas: 2013

description: We transplanted three common species of salt marsh plants (Spartina alterniflora, Batis maritima, Sarcocornia sp.) into eight experimental plots (24 x 42 m) varying in plot-level mangrove cover in Port Aransas, Texas in 2013. We transplanted marsh plants into 3 x 3 m “cells” with one of 3 different vegetation treatments (cleared, mangrove, pneumatophores) in each of the eight plots. Marsh plants were harvested to measure final size.
DOI: 10.5517/ccdc.csd.cc1z6jl9
title: CCDC 1823531: Experimental Crystal Structure Determination

description: Related Article: Fan Yu, Pei Li, Mengli Xu, Guoyong Xu, Yinna Na, Shaojie Zhang, Fuzhou Wang, Chen Tan|2021|Polymer|229|124023|doi:10.1016/j.polymer.2021.124023
DOI: 10.5517/ccdc.csd.cc1z6jpd
title: CCDC 1823534: Experimental Crystal Structure Determination

description: Related Article: Fan Yu, Pei Li, Mengli Xu, Guoyong Xu, Yinna Na, Shaojie Zhang, Fuzhou Wang, Chen Tan|2021|Polymer|229|124023|doi:10.1016/j.polymer.2021.124023
DOI: 10.5517/ccdc.csd.cc1m9qj5
title: CCDC 1498897: Experimental Crystal Structure Determination

description: Related Article: T. Hannah Clara, D. Reuben Jonathan, R. Ragu, M. NizamMohideen, Johanan Christian Prasana|2021|J.Solid State Chem.|302|122382|doi:10.1016/j.jssc.2021.122382
DOI: 10.5517/ccdc.csd.cc25nh7l
title: CCDC 2015689: Experimental Crystal Structure Determination

description: Related Article: Mandeep Kaur, Noor U Din Reshi, Kamaless Patra, Arindom Bhattacherya, Sooraj Kunnikuruvan, Jitendra K. Bera|2021|Chem.-Eur.J.|27|10737|doi:10.1002/chem.202101360
DOI: 10.5517/ccdc.csd.cc25nh8m
title: CCDC 2015690: Experimental Crystal Structure Determination

description: Related Article: Mandeep Kaur, Noor U Din Reshi, Kamaless Patra, Arindom Bhattacherya, Sooraj Kunnikuruvan, Jitendra K. Bera|2021|Chem.-Eur.J.|27|10737|doi:10.1002/chem.202101360
DOI: 10.5517/ccdc.csd.cc25nh9n
title: CCDC 2015691: Experimental Crystal Structure Determination

description: Related Article: Mandeep Kaur, Noor U Din Reshi, Kamaless Patra, Arindom Bhattacherya, Sooraj Kunnikuruvan, Jitendra K. Bera|2021|Chem.-Eur.J.|27|10737|doi:10.1002/chem.202101360
DOI: 10.5517/ccdc.csd.cc25nhbp
title: CCDC 2015692: Experimental Crystal Structure Determination

description: Related Article: Mandeep Kaur, Noor U Din Reshi, Kamaless Patra, Arindom Bhattacherya, Sooraj Kunnikuruvan, Jitendra K. Bera|2021|Chem.-Eur.J.|27|10737|doi:10.1002/chem.202101360
DOI: 10.5517/ccdc.csd.cc261c6v
title: CCDC 2027096: Experimental Crystal Structure Determination

description: Related Article: Lei Xu, Yuxun Hao, Xiao Yang, Zhipeng Wang, Chao Xu, Nataliya E. Borisova, Mingze Sun, Xingwang Zhang, Lecheng Lei, Chengliang Xiao|2021|Chem.-Eur.J.|27|10717|doi:10.1002/chem.202101224
DOI: 10.5517/ccdc.csd.cc26nsth
title: CCDC 2045777: Experimental Crystal Structure Determination

description: Related Article: Lorenzo Biancalana, Michele De Franco, Gianluca Ciancaleoni, Stefano Zacchini, Guido Pampaloni, Valentina Gandin, Fabio Marchetti|2021|Chem.-Eur.J.|27|10169|doi:10.1002/chem.202101048
DOI: 10.5517/ccdc.csd.cc26nsvj
title: CCDC 2045778: Experimental Crystal Structure Determination

description: Related Article: Lorenzo Biancalana, Michele De Franco, Gianluca Ciancaleoni, Stefano Zacchini, Guido Pampaloni, Valentina Gandin, Fabio Marchetti|2021|Chem.-Eur.J.|27|10169|doi:10.1002/chem.202101048
DOI: 10.5517/ccdc.csd.cc26nswk
title: CCDC 2045779: Experimental Crystal Structure Determination

description: Related Article: Lorenzo Biancalana, Michele De Franco, Gianluca Ciancaleoni, Stefano Zacchini, Guido Pampaloni, Valentina Gandin, Fabio Marchetti|2021|Chem.-Eur.J.|27|10169|doi:10.1002/chem.202101048
DOI: 10.5517/ccdc.csd.cc26nsxl
title: CCDC 2045780: Experimental Crystal Structure Determination

description: Related Article: Lorenzo Biancalana, Michele De Franco, Gianluca Ciancaleoni, Stefano Zacchini, Guido Pampaloni, Valentina Gandin, Fabio Marchetti|2021|Chem.-Eur.J.|27|10169|doi:10.1002/chem.202101048
DOI: 10.5517/ccdc.csd.cc26nsym
title: CCDC 2045781: Experimental Crystal Structure Determination

description: Related Article: Lorenzo Biancalana, Michele De Franco, Gianluca Ciancaleoni, Stefano Zacchini, Guido Pampaloni, Valentina Gandin, Fabio Marchetti|2021|Chem.-Eur.J.|27|10169|doi:10.1002/chem.202101048
DOI: 10.5517/ccdc.csd.cc26qqzn
title: CCDC 2047642: Experimental Crystal Structure Determination

description: Related Article: Aynaz Talebi, Mehdi Salehi, Ali Khaleghian|2021|J.Mol.Struct.|1246|131076|doi:10.1016/j.molstruc.2021.131076
DOI: 10.5517/ccdc.csd.cc26qr0q
title: CCDC 2047643: Experimental Crystal Structure Determination

description: Related Article: Aynaz Talebi, Mehdi Salehi, Ali Khaleghian|2021|J.Mol.Struct.|1246|131076|doi:10.1016/j.molstruc.2021.131076
DOI: 10.5517/ccdc.csd.cc26wp1v
title: CCDC 2052387: Experimental Crystal Structure Determination

description: Related Article: Yasunori Toda, Takayuki Yoshida, Kaoru Arisue, Kazuaki Fukushima, Hiroyoshi Esaki, Ayaka Kikuchi, Hiroyuki Suga|2021|Chem.-Eur.J.|27|10578|doi:10.1002/chem.202101491
DOI: 10.5517/ccdc.csd.cc26wp2w
title: CCDC 2052388: Experimental Crystal Structure Determination

description: Related Article: Yasunori Toda, Takayuki Yoshida, Kaoru Arisue, Kazuaki Fukushima, Hiroyoshi Esaki, Ayaka Kikuchi, Hiroyuki Suga|2021|Chem.-Eur.J.|27|10578|doi:10.1002/chem.202101491
DOI: 10.3886/e146281v1
title: Variability in Preschool CLASS Scores and Children's School Readiness

description: The Classroom Assessment Scoring System (CLASS) is a widely administered measure of classroom quality that assesses teacher-child interactions in the domains of Emotional Support, Classroom Organization, and Instructional Support. We use data from an evaluation of state-funded prekindergarten provided to 684 children from families with low incomes (M age = 57.56 months, 48% male) to examine the extent to which CLASS scores vary over the course of an observational period within a single day and investigate whether this variability is related to children’s school readiness at the end of the preschool year, holding constant two additional measures of quality. Teacher-child interactions in all three domains were moderately stable. Mean Classroom Organization was positively related to math and variability in Classroom Organization was negatively related to literacy. Mean Instructional Support was negatively associated with language. Findings have implications for programs that utilize the CLASS to make highstakes decision and inform professional development.
description: Response Rates: Data for this project came from a sample of 684 children (n = 180 classrooms) participating in an evaluation of state-funded prekindergarten. Data were collected during the following years for each cohort: cohort 1 (fall 2015-spring 2016; cohort 2: fall 2016-spring 2017; cohort 3: fall 2018-spring 2019). Sampling for each cohort followed similar recruitment processes. The same standardized assessments were administered to each cohort in the fall and spring of the prekindergarten year to measure children’s school readiness (math, literacy, and vocabulary). Classroom quality data were collected in the winter of the prekindergarten year via a global observational assessment. Assessors were trained on similar data collection procedures and scoring was implemented identically across cohorts.
description: a sample of children from low-income families participating in state-funded prekindergarten.
description: other;
DOI: 10.5517/ccdc.csd.cc2714q5
title: CCDC 2056686: Experimental Crystal Structure Determination

description: Related Article: Mohammed Anif Pasha, Swamy Peraka, Dhevalapally B. Ramachary|2021|Chem.-Eur.J.|27|10563|doi:10.1002/chem.202100985
DOI: 10.5517/ccdc.csd.cc2714r6
title: CCDC 2056687: Experimental Crystal Structure Determination

description: Related Article: Mohammed Anif Pasha, Swamy Peraka, Dhevalapally B. Ramachary|2021|Chem.-Eur.J.|27|10563|doi:10.1002/chem.202100985
DOI: 10.5517/ccdc.csd.cc2717xg
title: CCDC 2056785: Experimental Crystal Structure Determination

description: Related Article: Mohammed Anif Pasha, Swamy Peraka, Dhevalapally B. Ramachary|2021|Chem.-Eur.J.|27|10563|doi:10.1002/chem.202100985
DOI: 10.5517/ccdc.csd.cc271sx0
title: CCDC 2057312: Experimental Crystal Structure Determination

description: Related Article: Fengbo Liu, Shagor Chowdhury, Roselyne Rosas, Valérie Monnier, Laurence Charles, Hakim Karoui, Didier Gigmes, Olivier Ouari, Floris Chevallier, Christophe Bucher, Anthony Kermagoret, Simin Liu, David Bardelang|2021|Org.Lett.|23|5283|doi:10.1021/acs.orglett.1c00773
DOI: 10.5517/ccdc.csd.cc272s7c
title: CCDC 2058252: Experimental Crystal Structure Determination

description: Related Article: Eva M. Gulotty, Kevin X. Rodriguez, Erin E. Parker, Brandon L. Ashfeld|2021|Chem.-Eur.J.|27|10349|doi:10.1002/chem.202100355
DOI: 10.5517/ccdc.csd.cc272s8d
title: CCDC 2058253: Experimental Crystal Structure Determination

description: Related Article: Eva M. Gulotty, Kevin X. Rodriguez, Erin E. Parker, Brandon L. Ashfeld|2021|Chem.-Eur.J.|27|10349|doi:10.1002/chem.202100355
DOI: 10.25345/c5tn9x
title: MassIVE MSV000087907 - Endophytic fungi from Brazilian Pantanal
title: Extracts from Daldinia sp. obatined from vegetal species of Pantanal
DOI: 10.6084/m9.figshare.15074117
title: Annotated R Code for Figure 3 from The three Ts of virulence evolution during zoonotic emergence

description: There is increasing interest in the role that evolution may play in current and future pandemics, but there is often also considerable confusion about the actual evolutionary predictions. This may be, in part, due to a historical separation of evolutionary and medical fields, but there is a large, somewhat nuanced body of evidence-supported theory on the evolution of infectious disease. In this review, we synthesize this evolutionary theory in order to provide framework for clearer understanding of the key principles. Specifically, we discuss the selection acting on zoonotic pathogens' transmission rates and virulence at spillover and during emergence. We explain how the direction and strength of selection during epidemics of emerging zoonotic disease can be understood by a three Ts framework: trade-offs, transmission and time scales. Virulence and transmission rate may trade-off, but transmission rate is likely to be favoured by selection early in emergence, particularly if maladapted zoonotic pathogens have ‘no-cost’ transmission rate improving mutations available to them. Additionally, the optimal virulence and transmission rates can shift with the time scale of the epidemic. Predicting pathogen evolution, therefore, depends on understanding both the trade-offs of transmission-improving mutations and the time scales of selection.
DOI: 10.6084/m9.figshare.15074117.v1
title: Annotated R Code for Figure 3 from The three Ts of virulence evolution during zoonotic emergence

description: There is increasing interest in the role that evolution may play in current and future pandemics, but there is often also considerable confusion about the actual evolutionary predictions. This may be, in part, due to a historical separation of evolutionary and medical fields, but there is a large, somewhat nuanced body of evidence-supported theory on the evolution of infectious disease. In this review, we synthesize this evolutionary theory in order to provide framework for clearer understanding of the key principles. Specifically, we discuss the selection acting on zoonotic pathogens' transmission rates and virulence at spillover and during emergence. We explain how the direction and strength of selection during epidemics of emerging zoonotic disease can be understood by a three Ts framework: trade-offs, transmission and time scales. Virulence and transmission rate may trade-off, but transmission rate is likely to be favoured by selection early in emergence, particularly if maladapted zoonotic pathogens have ‘no-cost’ transmission rate improving mutations available to them. Additionally, the optimal virulence and transmission rates can shift with the time scale of the epidemic. Predicting pathogen evolution, therefore, depends on understanding both the trade-offs of transmission-improving mutations and the time scales of selection.