cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.6007946.v1
title: Clinical, Anthropometric and Biochemical Characteristics of Patients with or without Genetically Confirmed Familial Hypercholesterolemia

description: Abstract Background: Familial hypercholesterolemia (FH) is a common autosomal dominant disorder, characterized by a high level of low-density lipoprotein cholesterol (LDL-C) and a high risk of premature cardiovascular disease. Objective: To evaluate clinical and anthropometric characteristics of patients with the familiar hypercholesterolemia (FH) phenotype, with or without genetic confirmation of FH. Methods: Forty-five patients with LDL-C &gt; 190 mg/dl were genotyped for six FH-related genes: LDLR, APOB, PCSK9, LDLRAP1, LIPA and APOE. Patients who tested positive for any of these mutations were considered to have genetically confirmed FH. The FH phenotype was classified according to the Dutch Lipid Clinic Network criteria. Results: Comparing patients with genetically confirmed FH to those without it, the former had a higher clinical score for FH, more often had xanthelasma and had higher LDL-C and apo B levels. There were significant correlations between LDL-C and the clinical point score for FH (R = 0.382, p = 0.037) and between LDL-C and body fat (R = 0.461, p = 0.01). However, patients with mutations did not have any correlation between LDL-C and other variables, while for those without a mutation, there was a correlation between LDL-C and the clinical point score. Conclusions: LDL-C correlated with the clinical point score and with body fat, both in the overall patient population and in patients without the genetic confirmation of FH. In those with genetically confirmed FH, there were no correlations between LDL-C and other clinical or biochemical variables in patients.
DOI: 10.6084/m9.figshare.6007940
title: Temperature affects the hypoxia tolerance of neotropical Cichlid Geophagus brasiliensis

description: ABSTRACT Oxygen and temperature are the most limiting factors in aquatic environments. Several species are exposed to variations of these factors in water because of physical, chemical and biological processes. The objective of this study was to evaluate the metabolic profile and the tolerance to the hypoxia of Geophagus brasiliensis exposed to changes in temperature and oxygen availability. The fish were exposed to 20 and 90% of oxygen saturation combined with different temperatures (20°, 24° and 28° C) for 8 h. Hepatic and muscular glycogen, as well as the activities of lactate dehydrogenase (LDH), malate dehydrogenase (MDH), citrate synthase (CS) and their ratios were evaluated. Both glycogen and MDH activity showed a significant difference in the liver. While CS showed increased activity only in the heart. The increase in LDH activity in the white muscle shows the importance of the anaerobic pathway as energy source in this tissue. The MDH / LDH ratio increased in all tissues, while CS / LDH increased in the liver and decreased in the heart. Based on the results of the present study it may be concluded that this species used the anaerobic metabolism as the main strategy for hypoxia tolerance.
DOI: 10.6084/m9.figshare.6007940.v1
title: Temperature affects the hypoxia tolerance of neotropical Cichlid Geophagus brasiliensis

description: ABSTRACT Oxygen and temperature are the most limiting factors in aquatic environments. Several species are exposed to variations of these factors in water because of physical, chemical and biological processes. The objective of this study was to evaluate the metabolic profile and the tolerance to the hypoxia of Geophagus brasiliensis exposed to changes in temperature and oxygen availability. The fish were exposed to 20 and 90% of oxygen saturation combined with different temperatures (20°, 24° and 28° C) for 8 h. Hepatic and muscular glycogen, as well as the activities of lactate dehydrogenase (LDH), malate dehydrogenase (MDH), citrate synthase (CS) and their ratios were evaluated. Both glycogen and MDH activity showed a significant difference in the liver. While CS showed increased activity only in the heart. The increase in LDH activity in the white muscle shows the importance of the anaerobic pathway as energy source in this tissue. The MDH / LDH ratio increased in all tissues, while CS / LDH increased in the liver and decreased in the heart. Based on the results of the present study it may be concluded that this species used the anaerobic metabolism as the main strategy for hypoxia tolerance.
DOI: 10.6084/m9.figshare.6007937
title: Nurse liaison: a strategy for counter-referral

description: ABSTRACT Objective: to identify the profile of the counter-referred patients by the “nurse liaison” and to describe the experience of the professionals who participated in the project. Method: intervention research, with twelve nursing nurses from a hospital and an Emergency Care Unit, and 26 nurses from Primary Health Care. Data were obtained through questionnaires and counter-referral forms. Results: Out of 43 counter-referred individuals, 62.8% are over sixty years, 53.5% are men with multi-pathologies. Among the positive aspects, the nurses highlighted the dialogue between health care services, agility in the acquisition of inputs for the continuity of care in primary care, benefiting patients after hospital discharge. The greatest challenge was the lack of time and the deficit of nurses to perform the function. Final considerations: the presence of the “nurse liaison” has proved to be an important strategy to improve integration between services and to promote continuity of care.
DOI: 10.6084/m9.figshare.6007937.v1
title: Nurse liaison: a strategy for counter-referral

description: ABSTRACT Objective: to identify the profile of the counter-referred patients by the “nurse liaison” and to describe the experience of the professionals who participated in the project. Method: intervention research, with twelve nursing nurses from a hospital and an Emergency Care Unit, and 26 nurses from Primary Health Care. Data were obtained through questionnaires and counter-referral forms. Results: Out of 43 counter-referred individuals, 62.8% are over sixty years, 53.5% are men with multi-pathologies. Among the positive aspects, the nurses highlighted the dialogue between health care services, agility in the acquisition of inputs for the continuity of care in primary care, benefiting patients after hospital discharge. The greatest challenge was the lack of time and the deficit of nurses to perform the function. Final considerations: the presence of the “nurse liaison” has proved to be an important strategy to improve integration between services and to promote continuity of care.
DOI: 10.6084/m9.figshare.6007931
title: Implementation of the Brazilian National Policy for Waste Management

description: Abstract In Brazil there has been great difficulty in politically and administratively integrating the different levels of government that are formulating and implementing these policies, especially in regard to the relationships between the government bodies formulating guidelines at the national level and those at the local level. According to current legislation, the municipalities are responsible for the management of urban solid waste (USW) and urban sanitation. Federal Law 12,305/2010, establishes the Brazilian National Policy on Solid Waste (PNRS), and establishes principles and objectives for the country, but these activities are to be implemented at the municipal level. Are these municipalities capable of fulfilling this task? This article proposes a methodology based on gap analysis using data from the National Sanitation Information System (Snis) to identify the extent to which PNRS has been implemented in the Rio de Janeiro Metropolitan Area (RJMA). The results show an increase in the universality of the service in RJMA municipalities, but most of the PNRS objectives have been ignored and there are no local policy guidelines to be put in place and monitored. In addition to this, we have found that there has been poor implementation of the federal law. By interpreting this finding through the theoretical framework of institutionalism, our conclusions raise new questions and identify possible paths for future research.
DOI: 10.6084/m9.figshare.6007931.v1
title: Implementation of the Brazilian National Policy for Waste Management

description: Abstract In Brazil there has been great difficulty in politically and administratively integrating the different levels of government that are formulating and implementing these policies, especially in regard to the relationships between the government bodies formulating guidelines at the national level and those at the local level. According to current legislation, the municipalities are responsible for the management of urban solid waste (USW) and urban sanitation. Federal Law 12,305/2010, establishes the Brazilian National Policy on Solid Waste (PNRS), and establishes principles and objectives for the country, but these activities are to be implemented at the municipal level. Are these municipalities capable of fulfilling this task? This article proposes a methodology based on gap analysis using data from the National Sanitation Information System (Snis) to identify the extent to which PNRS has been implemented in the Rio de Janeiro Metropolitan Area (RJMA). The results show an increase in the universality of the service in RJMA municipalities, but most of the PNRS objectives have been ignored and there are no local policy guidelines to be put in place and monitored. In addition to this, we have found that there has been poor implementation of the federal law. By interpreting this finding through the theoretical framework of institutionalism, our conclusions raise new questions and identify possible paths for future research.
DOI: 10.6084/m9.figshare.6007910
title: FAMILY HEALTH SUPPORT CENTERS: CONCEPTIONS, IMPLICATIONS AND CHALLENGES FOR THE MATRIX SUPPORT

description: Abstract This study intended to analyze the assigned meaning and the contributions of the work of the Family Health Support Centers, as well as the barriers and challenges to the daily practice of matrix support. This is a qualitative study involving multiple cases, which was performed in six cities in Bahia, Brazil. Semi-structured interviews were conducted with 43 professionals from the support centers and 40 from the family health teams. We used the theoretical reference of the matrix support in the pedagogical, therapeutic and institutional dimensions. The results were grouped into three categories: (Mis) Understandings about the work of the support centers; Infrastructure and working conditions; Appreciation and management of work. Our study has unveiled divergent understandings among supporters and family health teams about the role of the matrix support process, with conflicting expectations and implications for work. The current infrastructure has proved to be insufficient and inappropriate for the work of matrix support. The little appreciation of the support centers was also highlighted through the low adherence of the community to the collective activities, unsatisfactory wages and excessive workload. Misunderstandings about the innovative nature of matrix support and structural difficulties indicate outstanding challenges for achieving the supportive function.
DOI: 10.6084/m9.figshare.6007910.v1
title: FAMILY HEALTH SUPPORT CENTERS: CONCEPTIONS, IMPLICATIONS AND CHALLENGES FOR THE MATRIX SUPPORT

description: Abstract This study intended to analyze the assigned meaning and the contributions of the work of the Family Health Support Centers, as well as the barriers and challenges to the daily practice of matrix support. This is a qualitative study involving multiple cases, which was performed in six cities in Bahia, Brazil. Semi-structured interviews were conducted with 43 professionals from the support centers and 40 from the family health teams. We used the theoretical reference of the matrix support in the pedagogical, therapeutic and institutional dimensions. The results were grouped into three categories: (Mis) Understandings about the work of the support centers; Infrastructure and working conditions; Appreciation and management of work. Our study has unveiled divergent understandings among supporters and family health teams about the role of the matrix support process, with conflicting expectations and implications for work. The current infrastructure has proved to be insufficient and inappropriate for the work of matrix support. The little appreciation of the support centers was also highlighted through the low adherence of the community to the collective activities, unsatisfactory wages and excessive workload. Misunderstandings about the innovative nature of matrix support and structural difficulties indicate outstanding challenges for achieving the supportive function.
DOI: 10.6084/m9.figshare.6007901
title: Global Longitudinal Strain Accuracy for Cardiotoxicity Prediction in a Cohort of Breast Cancer Patients During Anthracycline and/or Trastuzumab Treatment

description: Abstract Background: The high cardiotoxicity morbidity and mortality rates associated with the antineoplastic therapy for breast cancer could be reduced with the early use of cardioprotective drugs. However, the low sensitivity of left ventricular ejection fraction limits its use in that preventive strategy. New parameters, such as global longitudinal strain, are being used in the early detection of contractile function changes. Objectives: To assess the incidence of cardiotoxicity in patients treated for breast cancer, the independent factors associated with that event, and the ability of strain to identify it early. Methods: Prospective observational study of consecutive outpatients diagnosed with breast cancer, with no previous antineoplastic treatment and no ventricular dysfunction, who underwent anthracycline and/or trastuzumab therapy. The patients were quarterly evaluated on a 6- to 12-month follow-up by an observer blind to therapy. Cox regression was used to evaluate the association of cardiotoxicity with clinical, therapeutic and echocardiographic variables. A ROC curve was built to identify the strain cutoff point on the third month that could predict the ejection fraction reduction on the sixth month. For all tests, the statistical significance level adopted was p ≤ 0.05. Results: Of 49 women (mean age, 49.7 ± 12.2 years), cardiotoxicity was identified in 5 (10%) on the third (n = 2) and sixth (n = 3) months of follow-up. Strain was independently associated with the event (p = 0.004; HR = 2.77; 95%CI: 1.39-5.54), with a cutoff point for absolute value of -16.6 (AUC = 0.95; 95%CI: 0.87-1.0) or a cutoff point for percentage reduction of 14% (AUC = 0.97; 95%CI: 0.9-1.0). Conclusion: The 14% reduction in strain (absolute value of -16.6) allowed the early identification of patients who could develop anthracycline and/or trastuzumab-induced cardiotoxicity.
DOI: 10.6084/m9.figshare.6007901.v1
title: Global Longitudinal Strain Accuracy for Cardiotoxicity Prediction in a Cohort of Breast Cancer Patients During Anthracycline and/or Trastuzumab Treatment

description: Abstract Background: The high cardiotoxicity morbidity and mortality rates associated with the antineoplastic therapy for breast cancer could be reduced with the early use of cardioprotective drugs. However, the low sensitivity of left ventricular ejection fraction limits its use in that preventive strategy. New parameters, such as global longitudinal strain, are being used in the early detection of contractile function changes. Objectives: To assess the incidence of cardiotoxicity in patients treated for breast cancer, the independent factors associated with that event, and the ability of strain to identify it early. Methods: Prospective observational study of consecutive outpatients diagnosed with breast cancer, with no previous antineoplastic treatment and no ventricular dysfunction, who underwent anthracycline and/or trastuzumab therapy. The patients were quarterly evaluated on a 6- to 12-month follow-up by an observer blind to therapy. Cox regression was used to evaluate the association of cardiotoxicity with clinical, therapeutic and echocardiographic variables. A ROC curve was built to identify the strain cutoff point on the third month that could predict the ejection fraction reduction on the sixth month. For all tests, the statistical significance level adopted was p ≤ 0.05. Results: Of 49 women (mean age, 49.7 ± 12.2 years), cardiotoxicity was identified in 5 (10%) on the third (n = 2) and sixth (n = 3) months of follow-up. Strain was independently associated with the event (p = 0.004; HR = 2.77; 95%CI: 1.39-5.54), with a cutoff point for absolute value of -16.6 (AUC = 0.95; 95%CI: 0.87-1.0) or a cutoff point for percentage reduction of 14% (AUC = 0.97; 95%CI: 0.9-1.0). Conclusion: The 14% reduction in strain (absolute value of -16.6) allowed the early identification of patients who could develop anthracycline and/or trastuzumab-induced cardiotoxicity.
DOI: 10.6084/m9.figshare.6007898
title: Causes of low vision in patients referred to the Low Vision Service in a Reference Center of Ophthalmology

description: Abstract Purpose: To identify the prevalence of the most common diseases diagnosed in the Low Vision Service (LVS) Methods: Seven hundred and thirteen patient’s clinical records were evaluated. The best corrected visual acuity (BCVA) in the better eye was collected. All of the diagnosed diseases related to visual impairment were identified and classified. A total of 220 patients (36.6%) fulfilled the concept of low vision (group 1), and 381 patients (63.39%) presented legal blindness (groups 2, 3, 4 and 5), according to the WHO Study Group on the Prevention of Blindness (Geneva, l972). Results: The most prevalent disorder was the group of Retinal Inherited Distrophies (n=124; 20.63%). Following the first group were Ocular toxoplasmosis with chorioretinal scars (118 cases, representing a prevalence of 19.63%), Myopic Maculopathy (38-6.32%), Age related Macular Degeneration (AMD) (36 cases, representing a prevalence of 6%). Conclusion: Planning and implementing preventive actions in ophthalmology requires appropriate comprehension about regional clinical problems. Social support, and a proper partnership between educational and health systems, are important to improve visual outcomes in patients diagnosed with low vision and legal blindness.
DOI: 10.6084/m9.figshare.6007898.v1
title: Causes of low vision in patients referred to the Low Vision Service in a Reference Center of Ophthalmology

description: Abstract Purpose: To identify the prevalence of the most common diseases diagnosed in the Low Vision Service (LVS) Methods: Seven hundred and thirteen patient’s clinical records were evaluated. The best corrected visual acuity (BCVA) in the better eye was collected. All of the diagnosed diseases related to visual impairment were identified and classified. A total of 220 patients (36.6%) fulfilled the concept of low vision (group 1), and 381 patients (63.39%) presented legal blindness (groups 2, 3, 4 and 5), according to the WHO Study Group on the Prevention of Blindness (Geneva, l972). Results: The most prevalent disorder was the group of Retinal Inherited Distrophies (n=124; 20.63%). Following the first group were Ocular toxoplasmosis with chorioretinal scars (118 cases, representing a prevalence of 19.63%), Myopic Maculopathy (38-6.32%), Age related Macular Degeneration (AMD) (36 cases, representing a prevalence of 6%). Conclusion: Planning and implementing preventive actions in ophthalmology requires appropriate comprehension about regional clinical problems. Social support, and a proper partnership between educational and health systems, are important to improve visual outcomes in patients diagnosed with low vision and legal blindness.
DOI: 10.6084/m9.figshare.6007895
title: CHEMINFORMATICS: AN INTRODUCTION

description: Cheminformatics is an interdisciplinary field between chemistry and informatics, which has evolved considerably since its inception in the 1960s. Initially, the cheminformatics community dealt primarily with practical and technical aspects of chemical structure representation, manipulation, and processing, while modern research explores a new role: the exploration and interpretation of large chemical databases and the discovery of new compounds with desired activity and safety profiles. Despite the recent release of several hallmark reviews addressing methods and application of cheminformatics written in Portuguese, so far there are no scientific articles presenting cheminformatics research to the Brazilian scientific community yet. To address this gap, we aim to introduce the field of cheminformatics to both students and researchers in a simple and didactic way by narrating important historical facts and contextualizing information within the scope of various applications.
DOI: 10.6084/m9.figshare.6007895.v1
title: CHEMINFORMATICS: AN INTRODUCTION

description: Cheminformatics is an interdisciplinary field between chemistry and informatics, which has evolved considerably since its inception in the 1960s. Initially, the cheminformatics community dealt primarily with practical and technical aspects of chemical structure representation, manipulation, and processing, while modern research explores a new role: the exploration and interpretation of large chemical databases and the discovery of new compounds with desired activity and safety profiles. Despite the recent release of several hallmark reviews addressing methods and application of cheminformatics written in Portuguese, so far there are no scientific articles presenting cheminformatics research to the Brazilian scientific community yet. To address this gap, we aim to introduce the field of cheminformatics to both students and researchers in a simple and didactic way by narrating important historical facts and contextualizing information within the scope of various applications.
DOI: 10.6084/m9.figshare.6007892
title: THE USE OF POLYSACCHARIDES EXTRACTED FROM SEED OF Persea americana var. Hass ON THE SYNTHESIS OF ACRYLIC HYDROGELS

description: This paper reports the use of polysaccharides extracted from seed of Persea americana var. Hass in the synthesis of acrylic hydrogels. The effects of the chemical composition (acrylamide/acrylic acid), the concentration of crosslinking agent (glycerol diacrylate) and the type of initiation (redox, photoinitiation) of the hydrogels were evaluated with and without polysaccharides. Xerogels were characterized by FTIR spectroscopy, differential scanning calorimetry (DSC) and scanning electron microscopy (SEM), while for the swollen hydrogels the swelling kinetic and mechanical properties were evaluated. The kinetic parameters were obtained using the second order equation proposed by Schott, where it is reported that by increasing the concentration of the crosslinking agent, the degree of swelling is reduced because of the greater structural level. The increase of the amount of acrylamide and the amount of polysaccharides causes also a decrease in the swelling degree. The type of initiation also affected the hydrogels swelling kinetic, the photoinitiated hydrogels were the ones that captured less water. Moreover, the increasing of the glass transition temperature and the compression modulus with the crosslinking agent concentration and molar ratio AAm/AAc are observed for hydrogels with and without polysaccharides. The results demonstrate a successful incorporation of polysaccharides into the polymeric network.