cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.5281/zenodo.7300017
title: Fragment screening using biolayer interferometry reveals ligands targeting the SHP-motif binding site of the AAA+ ATPase p97

description: Biosensor techniques have become increasingly important for fragment-based drug discovery during the last years. The AAA+ ATPase p97 is an essential protein with key roles in protein homeostasis and a possible target for cancer chemotherapy. Currently available p97 inhibitors address its ATPase activity and globally impair p97-mediated processes. In contrast, inhibition of cofactor binding to the N-domain by a protein-protein-interaction inhibitor would enable the selective targeting of specific p97 functions. Here, we describe a biolayer interferometry-based fragment screen targeting the N-domain of p97 and demonstrate that a region known as SHP-motif binding site can be targeted with small molecules. Guided by molecular dynamics simulations, the binding sites of selected screening hits were postulated and experimentally validated using protein- and ligand-based NMR techniques, as well as X-ray crystallography, ultimately resulting in the first structure of a small molecule in complex with the N-domain of p97. The identified fragments provide insights into how this region could be targeted and present first chemical starting points for the development of a protein-protein interaction inhibitor preventing the binding of selected cofactors to p97. <br> Here we publish the primary data of the biolayer-interferometry (BLI), STD-NMR, HSQC-NMR and mixed-solvent MD simulation results.<br> For BLI, the sensorgrams of 10 binding fragments identified in the screening are given. Measurements were conducted with the N-domain and the ND1-construct of p97. Additionaly, the measurements with ADP as positive control (n=6) are provided.<br> Four of the 10 fragments were selected as most promising hits for further investigation: TROLL2, TROLL7, TROLL8 and TROLL12. For these fragemnts, the STD-NMR build-up data, the HSQC-NMR spectra and the representative poses from the mixed solvent MD simulations used for CORCEMA predictions are provided. For TROLL2 the anomalous map of the bromine atom of the crystal structure (PDB entry: 7PUX) is given.
DOI: 10.34740/kaggle/dsv/4488818
title: YouTube Trending Video Dataset (updated daily)
DOI: 10.6084/m9.figshare.21518136
title: Enhancement of surface properties of polyetheretherketone implant material by fractional laser texturing

description: These dataset files contain the raw data obtained in this study. The data is structured in Excel spreadsheets. Each contains a table of data in which columns represent the tested groups and the rows represent the number of samples in each group. Each spreadsheet contains a dataset for a single test.
DOI: 10.6084/m9.figshare.21518136.v4
title: Enhancement of surface properties of polyetheretherketone implant material by fractional laser texturing

description: These dataset files contain the raw data obtained in this study. The data is structured in Excel spreadsheets. Each contains a table of data in which columns represent the tested groups and the rows represent the number of samples in each group. Each spreadsheet contains a dataset for a single test.
DOI: 10.34740/kaggle/dsv/4488838
title: 2021 World Population (updated daily)
DOI: 10.48366/r249037
title: Evolution of the interpretation of the X-ray spectrum originated from highly charged ions (HCI) produced in laboratory experiments, and space observations of cosmic X-ray sources.

description: Transition energies of highly charged ions is a topic of much interest in atomic physics. In the laboratory, the production of HCIs requires high technology plasma sources and precision measurements from dedicated spectrometers. The emission by HCIs is also of utmost interest for the interpretation of the spectrum from astrophysical sources; therefore, fundamental, for designing the tasks of recent and future space observatories. Here is a comparison that reports the recent historical collaboration between laboratory and space observations of cosmic X-ray sources.
DOI: 10.5281/zenodo.7313619
title: Diagnostic accuracy of Panbio™ rapid antigen test for SARS-CoV-2 in paediatric population

description: The aim was to evaluate the accuracy of the Panbio<sup>TM</sup> Rapid Antigen Test for SARS-CoV-2 in the setting of a primary health care centre (PHC) in paedriatic population, with use of the Reverse Transcription-Polymerase Chain Reaction (RT-PCR) as gold standard.
DOI: 10.5281/zenodo.7313618
title: Diagnostic accuracy of Panbio™ rapid antigen test for SARS-CoV-2 in paediatric population

description: The aim was to evaluate the accuracy of the Panbio<sup>TM</sup> Rapid Antigen Test for SARS-CoV-2 in the setting of a primary health care centre (PHC) in paedriatic population, with use of the Reverse Transcription-Polymerase Chain Reaction (RT-PCR) as gold standard.
DOI: 10.48420/21533550
title: XRD analysis of freeze-dried MXene synthesis product with an internal standard - PANalytical X'Pert Pro

description: Run coupled θ:2θ scans of freeze-dried and powdered Ti<sub>3</sub>C<sub>2</sub> MXene synthesis product mixed with an internal standard to confirm the synthesis success and facilitate quantitative phase analysis (QPA)
DOI: 10.48420/21533550.v1
title: XRD analysis of freeze-dried MXene synthesis product with an internal standard - PANalytical X'Pert Pro

description: Run coupled θ:2θ scans of freeze-dried and powdered Ti<sub>3</sub>C<sub>2</sub> MXene synthesis product mixed with an internal standard to confirm the synthesis success and facilitate quantitative phase analysis (QPA)
DOI: 10.34740/kaggle/dsv/4488868
title: Elon Musk Tweets
DOI: 10.5281/zenodo.7313631
title: DATASET SPARC Europe Open Education in European Libraries of Higher Education Survey 2022

description: This is the anonymised dataset for the 2022 edition of the SPARC Europe Open Education Survey amongst Higher Education libraries in Europe.
DOI: 10.5281/zenodo.7313632
title: DATASET SPARC Europe Open Education in European Libraries of Higher Education Survey 2022

description: This is the anonymised dataset for the 2022 edition of the SPARC Europe Open Education Survey amongst Higher Education libraries in Europe.
DOI: 10.6084/m9.figshare.21541659.v1
title: 221111TeacherPraiseDataset.sav

description: Dataset related to the manuscript entitled: "Wow, you're really smart" - How children's self-esteem affects teachers' praise.
DOI: 10.6084/m9.figshare.21542640
title: TeacherPraise_Dataset

description: Dataset related to the manuscript entitled "Wow, You're Really Smart" - How Children's Self-Esteem Affects Teachers' Praise
DOI: 10.6084/m9.figshare.21542640.v1
title: TeacherPraise_Dataset

description: Dataset related to the manuscript entitled "Wow, You're Really Smart" - How Children's Self-Esteem Affects Teachers' Praise
DOI: 10.6084/m9.figshare.21541659
title: TeacherPraise_Dataset

description: Dataset related to the manuscript entitled: "Wow, you're really smart" - How children's self-esteem affects teachers' praise
DOI: 10.6084/m9.figshare.21541659.v3
title: TeacherPraise_Dataset

description: Dataset related to the manuscript entitled: "Wow, you're really smart" - How children's self-esteem affects teachers' praise
DOI: 10.6084/m9.figshare.21541659.v2
title: TeacherPraise_Dataset

description: Dataset related to the manuscript entitled: "Wow, you're really smart" - How children's self-esteem affects teachers' praise
DOI: 10.11583/dtu.21387591
title: Tinnitus subtyping - RAW data

description: Raw data for the individual measures assessed. The measures include: <br> - Adaptive Categorial Loudness Scaling (ACALOS) - High-frequency audiometry - Middle-ear muscle reflex - Psychophysical tuning curves (PTC) - Tinnitus Likeness - Tinnitus Masking Curves (TMC) <br> All data are in ASCII format
DOI: 10.11583/dtu.21387591.v1
title: Tinnitus subtyping - RAW data

description: Raw data for the individual measures assessed. The measures include: <br> - Adaptive Categorial Loudness Scaling (ACALOS) - High-frequency audiometry - Middle-ear muscle reflex - Psychophysical tuning curves (PTC) - Tinnitus Likeness - Tinnitus Masking Curves (TMC) <br> All data are in ASCII format
DOI: 10.6084/m9.figshare.21542658
title: Raw data of A blend of natural plant prebiotics, Shenling Baizhu San, regulates gut microbiota: A systematic review and meta-analyses

description: This is the raw data from the meta-analysis
DOI: 10.6084/m9.figshare.21542658.v1
title: Raw data of A blend of natural plant prebiotics, Shenling Baizhu San, regulates gut microbiota: A systematic review and meta-analyses

description: This is the raw data from the meta-analysis
DOI: 10.5445/ir/1000150744
title: Transformation Kinetics of LiBH$_{4}$–MgH$_{2}$ for Hydrogen Storage
DOI: 10.23637/oa-oe-1935002-1
title: Soil Fumigation Experiment, Spring Oats, Pastures, 1935

description: Numbers of eelworms in soil before and after fumigant treatments. This dataset consists of the plan, treatments, cultivations, yields and numbers of eelworm cysts relating to the Fumigation Experiment conducted in the field, Pastures, at Rothamsted. then Experimental Station, in 1935.
description: In March 1935, 400 grams of soil were sampled and the number of eelworm cysts were counted. Fumigants were added to the soil, oats were sown and harvested in August. In October the plots were sampled again and the final number of cysts recorded.
description: System of replication: 4 randomised blocks of 12 plots each. Area of each plots: 1/80 acre (30lks. X 41.7 lks.). Treatments: No fumigant (O), single (1) and double (2) dressings of "cymag" (CM), carbon disulphode jelly (S), chlordinitrobenzene (N) and "seekay" (CK), at the following rates of application per acre for the single dressing: 1 CM, 7.5 cwt.; 1 S, 24.3 cwt.; 1 N, 2.0 cwt. and 1 CK, 5.0 cwt. Basal Manuring: 1 cwt. sulphate of ammonia per acre. Cultivations: Ploughed: March 21 and 22. Fumigants ploughed in. Harrowed: March 25 and 26. Rolled: March 26. Drilled: March 26. Harrowed: March 27. Rolled: March 27. Harrowed: May 3. Harvested: August 9. Variety: Marvellous. Previous crop: Spring oats. Special Note: The ratio of weeds to total oats was determined by sampling at harvesting, two random samples being taken per plot. Standard Errors per plot: Grain: 3.38 cwt. per acre or 28.5%; straw: 6.17 cwt. per acre or 30.4%; weeds: 5.07 cwt. per acre.
description: This experiment is originally documented in the Rothamsted Annual Report of 1935 pages 176-178 as digitally archived in eRADoc "Other Experiments at Rothamsted" (1936) Report for 1935, https://doi.org/10.23637/ERADOC-1-67 None None
DOI: 10.23637/ex4-oadata-001-01
title: Exhaustion Land yields (spring barley and winter wheat) and assorted crop & soil phosphate (P) data, 1974-2008

description: This dataset contains data from the long-term Exhaustion Land experiment at Rothamsted Research, specifically grain and straw yields (spring barley to 1991, thereafter winter wheat), % phosphorous (P) and P uptake (1976-2008), soil Olsen P (plant available P) and Total P (1974-2008) from the long-term Exhaustion Land experiment (established 1856) at Rothamsted Research. The experiment as a whole underwent five different phases of treatment (see below). This data is from that half of the experiment, established in 1986, called the 'P Test' which tested the effects of different levels of plant available P on crop yields and P uptake. It also contains data from the preceding 10/12 years. Prior to the 'P test', fertilizer N was applied. This had increased yields and allowed the crop to take greater advantage of the P and K residues remaining in the soil from an earlier phase (Phase I) of the experiment. These were initially large but declined as amounts of phosphate in the soil declined. In Phase IV, from 1986, because the P residues had been exhausted it was decided to see how quickly this decline in soil fertility could be reversed - annual cumulative dressings of P as triple phosphate were tested (four different rates on four sub-plots) and spring barley grown - this is known as the 'P test'. Basal N & K were applied so that was not limited. Yield responses to available-P were rapid and showed that above a critical level on this soil, of about 10-12 mg kg P there is no further increase in yield. No P was applied between 1993-1999. Maintenance dressings of P have been applied since 2000 (but not to the P0 sub-plots).
description: The data contained in this spreadsheet are derived from data measured at Rothamsted Research, Harpenden. Please contact the e-RA Curators for further details. None None
DOI: 10.6084/m9.figshare.19691905
title: Monte Carlo Simulation Outputs for global OC-FeR

description: Model outputs simulating the size of the global sink of carbon associated with reactive iron worldwide.
DOI: 10.23637/oa-oe-1936004-1
title: Soil Fumigation Experiment, Spring Oats, Pastures, Residual effects 1936

description: Numbers of eelworms in soil before and after fumigant treatments - Residual effects. This dataset consists of the plan, treatments, cultivations, yields and numbers of eelworm cysts relating to the fumigation Experiment conducted in Pastures at Rothamsted. then Experimental Station, in 1936, following on from 1935.
description: Two random samples of 50 grms soil were taken per half plot Dec 1 and 2 and third cysts count made.
description: Area of each plots: 1/80 acre (30lks. X 41.7 lks.). Treatments: No fumigant (O), single (1) and double (2) dressings of "cymag" (CM), carbon disulphide jelly (S), chlordinitrobenzene (N) and "seekay" (CK), at the following rates of application per acre for the single dressing: 1 CM, 7.5 cwt.; 1S, 24.3 cwt.; 1N, 2.0 cwt. and 1CK, 5.0 cwt., applied in 1935. Sulphate of ammonia (A) at the rate of 0.4 cwt. and 0.8 cwt. N per acre, applied in 1936. Basal Manuring: Nil. Cultivations, etc: Ploughed: Aug. 27-29 and Feb. 10-March 13. Spring-tine harrowed: March 19. Rolled, harrowed, sulphate of ammonia applied and drilled; March 20.. Harrowed: May 8. Rolled: May 9. Harvested: Aug. 7. Variety: Marvellous. Previous crop: Oats. (See 1935 Report, p. 176). Special Note: The entire produce was weighed, Oats plus weeds. Weight of oats was determined by sampling a strip 30 lks. X 1 yd. Third cysts count; Dec. 1 and 2. Two random samples of about 50 grms. of soil were taken per half plot. Standard Errors per plot: Weeds: 22.4 cwt. per acre or 19.8%. 3rd cyst count: sampling error 32.3 or 16.6%; experimental error 59.9 or 30.7%.
description: This experiment is originally documented in the Rothamsted Annual Report of 1936 pages 211-212 as digitally archived in eRADoc; Other Experiments at Rothamsted (1937) Report For 1936, pp 211-212 https://doi.org/10.23637/ERADOC-1-68. This experiment data consists of 48 observations with 4 randomised blocks of 12 treatment plots. None
DOI: 10.5281/zenodo.7308091
title: Dataset and R code: Prior exposure to B. pertussis shapes the mucosal antibody response to acellular pertussis booster vaccination

description: The R code and dataset for the figures created in the Nature communications manuscript titled "<strong>Prior exposure to <em>B. pertussis </em>shapes the mucosal antibody response to acellular pertussis booster vaccination"</strong>. contains: - excel dataset including the parameters needed for the figures - R code document with the code used to produce the figures and statistical analyses
DOI: 10.5281/zenodo.7308090
title: Dataset and R code: Prior exposure to B. pertussis shapes the mucosal antibody response to acellular pertussis booster vaccination

description: The R code and dataset for the figures created in the Nature communications manuscript titled "<strong>Prior exposure to <em>B. pertussis </em>shapes the mucosal antibody response to acellular pertussis booster vaccination"</strong>. contains: - excel dataset including the parameters needed for the figures - R code document with the code used to produce the figures and statistical analyses
DOI: 10.21227/gme5-qk37
title: Test traces

description: This dataset include all the test traces used in the paper.
DOI: 10.17632/s98hbvshjd.2
title: Supporting information for "An unusually warm upper crust in the late Paleozoic North China continental arc: implications for the thermal modification of the giant Bayan Obo REE deposit

description: The dataset is the supporting information for the manuscript entitled "An unusually warm upper crust in the late Paleozoic North China continental arc: implications for the thermal modification of the giant Bayan Obo REE deposit". 
This supporting information includes:
1. SI. Supporting Information includes sample descriptions (Text S1), detail analytical methods for mineral composition analyses, Laser ablation-inductively coupled plasma-mass spectrometer (LA-ICP-MS) U-Pb dating and trace element analyses and 40Ar/39Ar incremental heating analysis (Text S2), detail description of U-Pb ages (Text S3), representative photomicrographs of samples (Figure S1), representative reflected-light, transmitted-light and CL images of zircons of samples for U-Pb dating and trace element analyses (Figures S2 to S9), inverse isochron plots (Figures S10).
2. SI. Table S1 is the electron microprobe analytical results of hornblende from the Permian granitoids near Bayan Obo deposit.
3. SI. Table S2 is the electron microprobe analytical results of plagioclase from the Permian granitoids near Bayan Obo deposit.
4. SI. Table S3 is the Al-in-hornblende geothermobarometric data of the Carboniferous-Permian arc plutons in the western part of the late Paleozoic northern North China continental arc (recalculated from Wu et al., 2014; Zhang and Zhao, 2017).
5. SI. Table S4 is the LA-ICP-MS U-Pb results of zircons from the samples for thermochronometric investigations.
6. SI. Table S5 is the 40Ar/39Ar analytical results of hornblende from sample 16219-3BY.
7. SI. Table S6 is the 40Ar/39Ar analytical results of biotite from sample 16147-1BY.
8. SI. Table S7 is the 40Ar/39Ar analytical results of biotite from sample 07148-5GY.
9. SI. Table S8 is the 40Ar/39Ar analytical results of biotite from sample 17099-1GY.
10. SI. Table S9 is the 40Ar/39Ar analytical results of hornblende from sample 10185-4BY.
11. SI. Table S10 is the 40Ar/39Ar analytical results of biotite from sample 10185-4BY.
12. SI. Table S11 is the 40Ar/39Ar analytical results of biotite from sample 13502-1BY.
13. SI. Table S12 is the 40Ar/39Ar analytical results of hornblende from sample 07173-1.
14. SI. Table S13 is the 40Ar/39Ar analytical results of biotite from sample 07173-1.
15. SI. Table S14 is the 40Ar/39Ar analytical results of hornblende from sample 08603-1.
16. SI. Table S15 is the 40Ar/39Ar analytical results of biotite from sample 08603-1.
17. SI. Table S16 is the 40Ar/39Ar analytical results of muscovite from sample 09219-1.
18. SI. Table S17 is the 40Ar/39Ar analytical results of muscovite from sample 09243-2.
19. SI. Table S18 is the 40Ar/39Ar analytical results of muscovite from sample 17105-1GY.
20. SI. Table S19 is the 40Ar/39Ar analytical results of biotite from sample 17107-1GY.
21. SI. Table S20 is the 40Ar/39Ar analytical results of hornblende from sample 17108-1BT.
22. SI. Table S21 is the 40Ar/39Ar analytical results of biotite from sample 17108-1BT.
DOI: 10.17632/s98hbvshjd.3
title: Supporting information for "An unusually warm upper crust in the late Paleozoic North China continental arc: implications for the thermal modification of the giant Bayan Obo REE deposit

description: The dataset is the supporting information for the manuscript entitled "An unusually warm upper crust in the late Paleozoic North China continental arc: implications for the thermal modification of the giant Bayan Obo REE deposit". 
This supporting information includes:
1. SI. Supporting Information includes sample descriptions (Text S1), detail analytical methods for mineral composition analyses, Laser ablation-inductively coupled plasma-mass spectrometer (LA-ICP-MS) U-Pb dating and trace element analyses and 40Ar/39Ar incremental heating analysis (Text S2), representative photomicrographs of samples (Figure S1), representative reflected-light, transmitted-light and CL images of zircons of samples for U-Pb dating and trace element analyses (Figures S2 to S9), inverse isochron plots (Figures S10).
2. SI. Table S1 is the electron microprobe analytical results of hornblende from the Permian granitoids near Bayan Obo deposit.
3. SI. Table S2 is the electron microprobe analytical results of plagioclase from the Permian granitoids near Bayan Obo deposit.
4. SI. Table S3 is the Al-in-hornblende geothermobarometric data of the Carboniferous-Permian arc plutons in the western part of the late Paleozoic northern North China continental arc (recalculated from Wu et al., 2014; Zhang and Zhao, 2017).
5. SI. Table S4 is the LA-ICP-MS U-Pb results of zircons from the samples for thermochronometric investigations.
6. SI. Table S5 is the 40Ar/39Ar analytical results of hornblende from sample 16219-3BY.
7. SI. Table S6 is the 40Ar/39Ar analytical results of biotite from sample 16147-1BY.
8. SI. Table S7 is the 40Ar/39Ar analytical results of biotite from sample 07148-5GY.
9. SI. Table S8 is the 40Ar/39Ar analytical results of biotite from sample 17099-1GY.
10. SI. Table S9 is the 40Ar/39Ar analytical results of hornblende from sample 10185-4BY.
11. SI. Table S10 is the 40Ar/39Ar analytical results of biotite from sample 10185-4BY.
12. SI. Table S11 is the 40Ar/39Ar analytical results of biotite from sample 13502-1BY.
13. SI. Table S12 is the 40Ar/39Ar analytical results of hornblende from sample 07173-1.
14. SI. Table S13 is the 40Ar/39Ar analytical results of biotite from sample 07173-1.
15. SI. Table S14 is the 40Ar/39Ar analytical results of hornblende from sample 08603-1.
16. SI. Table S15 is the 40Ar/39Ar analytical results of biotite from sample 08603-1.
17. SI. Table S16 is the 40Ar/39Ar analytical results of muscovite from sample 09219-1.
18. SI. Table S17 is the 40Ar/39Ar analytical results of muscovite from sample 09243-2.
19. SI. Table S18 is the 40Ar/39Ar analytical results of muscovite from sample 17105-1GY.
20. SI. Table S19 is the 40Ar/39Ar analytical results of biotite from sample 17107-1GY.
21. SI. Table S20 is the 40Ar/39Ar analytical results of hornblende from sample 17108-1BT.
22. SI. Table S21 is the 40Ar/39Ar analytical results of biotite from sample 17108-1BT.
DOI: 10.17632/fmf9r9hhmr.1
title: TCF7L2 and Type 2 Diabetes Mellitus

description: Studies in different population have found a significant association of single nucleotide polymorphism (SNP) in transcription factor 7-like 2 (TCF7L2) with type 2 diabetes mellitus (T2DM). We aimed to see the association of SNP rs12255372 (G/T) in the TCF7L2 gene and T2DM in Bangladeshi population. This case-control study was conducted on 67 T2DM cases and 65 healthy controls. Age, gender, body mass index (BMI) and blood pressure were recorded. Bio-chemical profiles of glucose and lipid were also analyzed. Direct sanger sequencing was done for genotyping of SNP. Geneotypic and allelic associations with T2DM were done by logistic regression models in SPSS. A p-value <0.05 was regarded significant. We found that having risk T allele either heterozygous or homozygous mutant form of rs12255372 TCF7L2 were significantly associated with T2DM.
DOI: 10.17632/n8scbwn6dc.1
title: Termite Acoustic and Temperature Signals

description: This dataset contains the continuous acoustic-temperature signals of termite infestation in 24 hours’ time.
DOI: 10.17632/n8scbwn6dc.2
title: Termite Acoustic and Temperature Signals

description: This dataset contains the continuous acoustic-temperature signals of termite infestation in 24 hours’ time.