cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.25146062.v1
title: <b>Appendices - Field courses for dummies: to what extent can ChatGPT design a higher education field course?</b>

description: We tested whether ChatGPT can play a role in designing field courses in higher education. In collaboration with ChatGPT, we developed two field courses; the first aimed at creating a completely new field trip, while the second was tailored to fit an existing university module, and then compared to the human module design. From our case studies, several insights emerged. These include the importance of precise prompt engineering and the need to iterate and refine prompts to achieve optimal results. We outlined a workflow for effective prompt engineering, emphasising clear objectives, sequential prompting, and feedback loops. We also identify best practices, including highlighting the importance of collaborating with human expertise, validating AI suggestions, and integrating adaptive management for continual refinement. While ChatGPT is a potent tool with the potential to save a significant amount of time and effort in field course design, human expertise remains indispensable for achieving optimal results
DOI: 10.6084/m9.figshare.16807130
title: Local Composite Quantile Regression for Regression Discontinuity

description: We introduce the local composite quantile regression (LCQR) to causal inference in regression discontinuity (RD) designs. Kai, Li and Zou study the efficiency property of LCQR, while we show that its nice boundary performance translates to accurate estimation of treatment effects in RD under a variety of data generating processes. Moreover, we propose a bias-corrected and standard error-adjusted <i>t</i>-test for inference, which leads to confidence intervals with good coverage probabilities. A bandwidth selector is also discussed. For illustration, we conduct a simulation study and revisit a classic example from Lee. A companion R package rdcqr is developed.
DOI: 10.6084/m9.figshare.16807130.v2
title: Local Composite Quantile Regression for Regression Discontinuity

description: We introduce the local composite quantile regression (LCQR) to causal inference in regression discontinuity (RD) designs. Kai, Li and Zou study the efficiency property of LCQR, while we show that its nice boundary performance translates to accurate estimation of treatment effects in RD under a variety of data generating processes. Moreover, we propose a bias-corrected and standard error-adjusted <i>t</i>-test for inference, which leads to confidence intervals with good coverage probabilities. A bandwidth selector is also discussed. For illustration, we conduct a simulation study and revisit a classic example from Lee. A companion R package rdcqr is developed.
DOI: 10.6084/m9.figshare.16807130.v1
title: Local Composite Quantile Regression for Regression Discontinuity

description: We introduce the local composite quantile regression (LCQR) to causal inference in regression discontinuity (RD) designs. <b>Kai <i>et al.</i></b> (<b>2010</b>) study the efficiency property of LCQR, while we show that its nice boundary performance translates to accurate estimation of treatment effects in RD under a variety of data generating processes. Moreover, we propose a bias-corrected and standard error-adjusted <i>t</i>-test for inference, which leads to confidence intervals with good coverage probabilities. A bandwidth selector is also discussed. For illustration, we conduct a simulation study and revisit a classic example from <b>Lee</b> (<b>2008</b>). A companion R package rdcqr is developed.
DOI: 10.6084/m9.figshare.7369967
title: Physiological and Genomic Analysis Reveals Candidate Genes Involved in Anthocyanin Biosynthesis in Colored-leaf Poplar ‘Caihong’ (Populus deltoides)

description: Leaf color is an important
agronomic trait that contributes to the ornamental value of plants. However, the
molecular mechanism of leaf coloration is still unclear. In our study, a
colored-leaf poplar ‘Caihong’ (CHP, bright red leaves) and wild-type L2025
(green leaves) were used to explore the mechanism of leaf coloration by
physiological and genomic analysis. Compared with leaves of L2025, leaves of
CHP had a higher content of anthocyanins and a lower content of total Chl and
carotenoids, and the ratio of anthocyanins to total Chl in CHP was more than 10
times of those in L2025, which may be the physiological reason why they show
red leaf color. Based on the whole genome resequencing and bioinformatics
analysis, eight structural genes and 20 regulatory genes associated with
anthocyanin biosynthesis carrying more than five non-synonymous SNPs in coding
regions were screened. These candidate genes were also identified according to
the qRT-PCR analysis, and eight structural genes and three MYB family genes
might play important roles in the leaf coloration of CHP. The above results
could provide reference to explore the molecular regulation mechanism of leaf
coloration in <i>Populus deltoids</i>, and
also provided insight into coloration of other woody plants.
DOI: 10.17028/rd.lboro.23098589
title: Supplementary information files for Complete removal of heavy metals with simultaneous efficient treatment of etching terminal wastewater using scaled-up microbial electrolysis cells

description: Supplementary files for article Complete removal of heavy metals with simultaneous efficient treatment of etching terminal wastewater using scaled-up microbial electrolysis cells
The treatment of actual low and high strengths etching terminal wastewater (ETW) from plating and electronic industry meeting national discharge standards is demonstrated in laboratory scale (1 L) and in scaled-up (40 L) microbial electrolysis cells (MECs). Both cylindrical single-chamber MECs achieved complete removal of heavy metals and efficient treatment of organics using either low strength ETW at an hydraulic retention time (HRT) of 5 d, or high strength wastewater at HRTs of 7 d (1 L) or 9 d (40 L). The removal rate of organics and heavy metals increased by 36-fold and scaled almost with the reactor volume ratio of 40. Electrode potentials in the scaled-up MECs (40 L) were resilient to the wastewater strength. Bacterial communities on both anodes and cathodes of the 1 L and the 40 L reactors experienced a selective shock and a significant community change after switching from low to high strengths wastewater, although reactor performance was effectively maintained. This study demonstrates complete removal of multiple heavy metals with simultaneous efficient wastewater treatment in MECs of different scales meeting China national discharge standards and provides a plausible approach for simultaneous removal of value-added products (e.g., heavy metals) and efficient treatment of practical etching terminal wastewater.
DOI: 10.6084/m9.figshare.21525816
title: Supplementary Information

description: This is the Supplementary Information for the paper
DOI: 10.6084/m9.figshare.11564511
title: Two Yb(III) coordination polymers: treatment effect with seventy-flavor pearl pills on cerebral ischemia by reducing the content of monoamine neurotransmitters

description: In the current study, we have successfully prepared two new Yb(III)-based coordination polymers with the chemical formulae of {[Yb(cptz)<sub>2</sub>(H<sub>2</sub>O)<sub>4</sub>]·NO<sub>3</sub>}<sub>n</sub> (<b>1</b>, Hcptz = (4-carboxylphenyl)-3-(prazin-2-yl)-1H-1,2,4-triazole) and {[Yb(Hpbdz)(H<sub>2</sub>O)<sub>2</sub>]·H<sub>2</sub>O}<sub>n</sub> (<b>2</b>, H<sub>4</sub>pbdz = 1,1′-(propane-1,3-diyl)bis(1H-imidazole-4,5-dicarboxylic acid) under hydrothermal conditions by using two N-heterocyclic multidentate N, O-donor bridging ligands. In the biological functional study, the promotion activity of compounds <b>1</b> and <b>2</b> on the treatment effect of the seventy-flavor pearl pills on the cerebral ischemic events was evaluated <i>in vivo</i>. Firstly, the content of dopamine and 5-serotonin in the brain after compounds <b>1</b> and <b>2</b> treatment was assessed by the ELISA detection kit. Then, the inhibitory effect of compounds <b>1</b> and <b>2</b> on the inflammatory level in the brain was determined with the ROS detection kit.
DOI: 10.6084/m9.figshare.11564511.v1
title: Two Yb(III) coordination polymers: treatment effect with seventy-flavor pearl pills on cerebral ischemia by reducing the content of monoamine neurotransmitters

description: In the current study, we have successfully prepared two new Yb(III)-based coordination polymers with the chemical formulae of {[Yb(cptz)<sub>2</sub>(H<sub>2</sub>O)<sub>4</sub>]·NO<sub>3</sub>}<sub>n</sub> (<b>1</b>, Hcptz = (4-carboxylphenyl)-3-(prazin-2-yl)-1H-1,2,4-triazole) and {[Yb(Hpbdz)(H<sub>2</sub>O)<sub>2</sub>]·H<sub>2</sub>O}<sub>n</sub> (<b>2</b>, H<sub>4</sub>pbdz = 1,1′-(propane-1,3-diyl)bis(1H-imidazole-4,5-dicarboxylic acid) under hydrothermal conditions by using two N-heterocyclic multidentate N, O-donor bridging ligands. In the biological functional study, the promotion activity of compounds <b>1</b> and <b>2</b> on the treatment effect of the seventy-flavor pearl pills on the cerebral ischemic events was evaluated <i>in vivo</i>. Firstly, the content of dopamine and 5-serotonin in the brain after compounds <b>1</b> and <b>2</b> treatment was assessed by the ELISA detection kit. Then, the inhibitory effect of compounds <b>1</b> and <b>2</b> on the inflammatory level in the brain was determined with the ROS detection kit.
DOI: 10.6084/m9.figshare.14185869
title: Identifying kinase targets of PPARγ in human breast cancer

description: Breast cancer is the most common cancer in women. Despite advances in screening women for genetic predisposition to breast cancer and risk stratification, a majority of women carriers remain undetected until they become affected. Thus, there is a need to develop a cost-effective, rapid, sensitive and non-invasive early-stage diagnostic method. Kinases are involved in all fundamental cellular processes and mutations in kinases have been reported as drivers of cancer. PPARγ is a ligand-activated transcription factor that plays important roles in cell proliferation and metabolism. However, the complete set of kinases modulated by PPARγ is still unknown. In this study, we identified human kinases that are potential PPARγ targets and evaluated their differential expression and gene pair correlations in human breast cancer patient dataset TCGA-BRCA. We further confirmed the findings in human breast cancer cell lines MCF7 and SK-BR-3 using a kinome array. We observed that gene pair correlations are lost in tumours as compared to healthy controls and could be used as a supplement strategy for diagnosis and prognosis of breast cancer.
DOI: 10.6084/m9.figshare.14185869.v1
title: Identifying kinase targets of PPARγ in human breast cancer

description: Breast cancer is the most common cancer in women. Despite advances in screening women for genetic predisposition to breast cancer and risk stratification, a majority of women carriers remain undetected until they become affected. Thus, there is a need to develop a cost-effective, rapid, sensitive and non-invasive early-stage diagnostic method. Kinases are involved in all fundamental cellular processes and mutations in kinases have been reported as drivers of cancer. PPARγ is a ligand-activated transcription factor that plays important roles in cell proliferation and metabolism. However, the complete set of kinases modulated by PPARγ is still unknown. In this study, we identified human kinases that are potential PPARγ targets and evaluated their differential expression and gene pair correlations in human breast cancer patient dataset TCGA-BRCA. We further confirmed the findings in human breast cancer cell lines MCF7 and SK-BR-3 using a kinome array. We observed that gene pair correlations are lost in tumours as compared to healthy controls and could be used as a supplement strategy for diagnosis and prognosis of breast cancer.
DOI: 10.5281/zenodo.10623556
title: Date and scripts for figures and table in "Assessing the urban heat island in the eastern Mediterranean and Middle East through high resolution regional climate simulations"

description: This zipped file contatins data and scripts used to produce figures and tables found in the manuscript titled "Assessing the urban heat island in the eastern Mediterranean and Middle East through high resolution regional climate simulations".
DOI: 10.5281/zenodo.10623557
title: Date and scripts for figures and table in "Assessing the urban heat island in the eastern Mediterranean and Middle East through high resolution regional climate simulations"

description: This zipped file contatins data and scripts used to produce figures and tables found in the manuscript titled "Assessing the urban heat island in the eastern Mediterranean and Middle East through high resolution regional climate simulations".
DOI: 10.24403/jp.1342498
title: Stützel, T.: Botanische Bestimmungsübungen. Praktische Einführung in die Pflanzenbestimmung. - Stuttgart : Verlag Eugen Ulmer, 2002 / [rezensiert von] H.-J. Zündorf
DOI: 10.6084/m9.figshare.14186120
title: RNAi silencing of rice black-streaked dwarf virus <i>P10</i> and two insect vector genes to reduce virus transmission protects rice plants against RBSDV

description: Rice black-streaked dwarf virus (RBSDV) is a virus transmitted by <i>Laodelphax striatellus</i> (<i>L. striatellus</i>), which poses a serious threat to rice production. P10, a major outer capsid protein of RBSDV, which plays a key role in viral infection. In this study, two <i>L. striatellus</i> transmission-related proteins, novel cuticular protein (NCuP) and receptor for activated protein kinase C (RACK), were identified as interacting with P10. Results demonstrated that virus-induced NCuP and RACK were silenced using double-stranded RNA (dsRNA) to reduce the quantity of virus in <i>L. striatellus</i>. The detection results after inoculation of RBSDV by <i>L. striatellus</i> showed that rice plants sprayed with dsP10+NCuP and dsP10+RACK and transgenic rice plants expressing both had higher disease resistance than those expressing dsP10, dsNCuP and dsRACK alone. Therefore, simultaneously interfering with both the expression of viral protein and the proteins that interact with them from insect vectors could enhance the control of viral transmission.
DOI: 10.6084/m9.figshare.14186120.v1
title: RNAi silencing of rice black-streaked dwarf virus <i>P10</i> and two insect vector genes to reduce virus transmission protects rice plants against RBSDV

description: Rice black-streaked dwarf virus (RBSDV) is a virus transmitted by <i>Laodelphax striatellus</i> (<i>L. striatellus</i>), which poses a serious threat to rice production. P10, a major outer capsid protein of RBSDV, which plays a key role in viral infection. In this study, two <i>L. striatellus</i> transmission-related proteins, novel cuticular protein (NCuP) and receptor for activated protein kinase C (RACK), were identified as interacting with P10. Results demonstrated that virus-induced NCuP and RACK were silenced using double-stranded RNA (dsRNA) to reduce the quantity of virus in <i>L. striatellus</i>. The detection results after inoculation of RBSDV by <i>L. striatellus</i> showed that rice plants sprayed with dsP10+NCuP and dsP10+RACK and transgenic rice plants expressing both had higher disease resistance than those expressing dsP10, dsNCuP and dsRACK alone. Therefore, simultaneously interfering with both the expression of viral protein and the proteins that interact with them from insect vectors could enhance the control of viral transmission.
DOI: 10.6084/m9.figshare.25125356.v2
title: <b>raw_data_IFNa_</b><b>induces_CCR5</b>

description: The treatment for HIV is called antiretroviral therapy (ART), which involves taking a combination of HIV medicines every day. ART cannot cure HIV but allows individuals to live longer, healthier lives. Treatment interruption can lead to relapse, but immune processes involved in relapse are not well understood. Some people with HIV are so-called elite controllers, who have a natural immunity to the virus and cope with HIV infection without needing treatments. Here, we compared the immune responses between elite controllers and individuals whose HIV medicines were interrupted. We demonstrate that IFNα, a small protein with an important role in controlling white blood cells, is produced in excess at the beginning of HIV infection and at levels that persist, resulting in poor HIV control without therapy.
DOI: 10.6084/m9.figshare.14710545
title: AST-120 Treatment Alters the Gut Microbiota Composition and Suppresses Hepatic Triglyceride Levels in Obese Mice

description: <b>Background:</b> The prevalence of nonalcoholic fatty liver disease (NAFLD) has been increasing worldwide. The existence of a relationship between the microbiota and the pathology of hepatic steatosis is also becoming increasingly clear. AST-120, an oral spherical carbon adsorbent, has been shown to be useful for delaying dialysis initiation and improving uremic symptoms in patients with chronic kidney disease. However, little is known about the effect of AST-120 on fatty liver. <b>Methods:</b> AST-120 (5% w/w) was administrated to 6-week-old male <i>db/db</i> mice for 8 weeks. The body weight, blood glucose and food consumption were examined. Hepatic triglyceride (TG) levels, lipid droplets and epididymal fat cell size were measured. The gut microbiota compositions were investigated in feces and cecum. <b>Results:</b> Significant decreases of the hepatic weight and hepatic TG levels were observed in the AST-120-treated <i>db/db</i> mice. Furthermore, AST-120 treatment was also associated with a decrease of Bacteroidetes, increase of Firmicutes, and a reduced ratio of Bacteroidetes to Firmicutes (B/F ratio) in the feces in the <i>db/db</i> mice. The B/F ratio in the feces was correlated with the liver weight and area of the liver occupied by lipid droplets in the <i>db/db</i> mice. <b>Conclusions:</b> These data suggest that AST-120 treatment alters the composition of the fecal microbiota and suppresses hepatic TG levels in the <i>db/db</i> mice.
DOI: 10.24403/jp.1342855
title: Heinrich, W. & Finke, L.: Reinhard Richter (1813-1884), Franz Ferdinand Meurer (1809-1882) und weitere Floristen : Betrachtungen über die Pflanzenwelt und die Landschaft um Saalfeld und Rudolstadt. - Rudolstädter Naturhist. Schriften, Suppl. 5. - Rudolstadt, 2002 / [rezensiert von] H.-J. Zündorf
DOI: 10.6084/m9.figshare.25151492
title: Appendices to IAWA 2275

description: <b>Appendix I.</b> Data matrix used for cluster analysis, with the characteristics of the woods of <i>Handroanthus barbatus</i>, H<i>. capitatus</i>, <i>H. </i><i>impetiginosus</i>, <i>H. incanus</i> and<i> H. serratifolius. </i>1 = presence, 0 = absence.<b>Appendix II</b>. Data matrix used for cluster analysis, with morphological characteristics of the leaves of <i>Handroanthus impetiginosus</i> and <i>H. serratifolius. 1 </i>= presence, 0 = absence.<b>Appendix III</b>. Data matrix used for cluster analysis, with the anatomical characteristics of the wood and morphological characteristics of the leaves of <i>Handroanthus impetiginosus</i> and <i>H. serratifolius.</i> 1 = presence, 0 = absence.
DOI: 10.6084/m9.figshare.16807625
title: Additional file 1 of Effects and mechanisms of mUCMSCs on ovarian structure and function in naturally ageing C57 mice

description: Additional file 1.
DOI: 10.6084/m9.figshare.16807625.v1
title: Additional file 1 of Effects and mechanisms of mUCMSCs on ovarian structure and function in naturally ageing C57 mice

description: Additional file 1.
DOI: 10.6084/m9.figshare.23623614
title: Systems pharmacology approach to explore the mechanisms of shufeng Jiedu Capsule on treating H1N1 infection

description: Influenza caused by the H1N1 virus still affects human health. There is currently no effective strategy against H1N1 virus infection. The present study is to evaluate the mechanism of Shufeng Jiedu Capsule (SFJDC) in the treatment of H1N1 infection using an integrated systems pharmacology approach and experimental validation. SFJDC is recommended for the treatment of H1N1 infection in traditional Chinese medicine (TCM), whose mechanism of action is not precise. We systematically analyzed SFJDC using a systematic pharmacology and ADME screening model, and predicted effective targets using systematic drug targeting (SysDT) algorithm. Subsequently, the network of interactions between compounds and targets was built to help in the discovery of new drugs. In addition, the pathway of molecular action was determined by using enrichment analysis from the predicted targets. what is more, molecular docking also applied to predict the specific binding sites and binding capacity of active compounds and related targets, which validated the results of the compounds-targets network (C-T network). Finally, the mechanism of SFJDC effect on autophagy and virus replication in H1N1 virus-infected RAW264.7 mouse macrophage cells was experimentally verified. The systematic pharmacology results suggested that 68 candidate compounds were obtained from SFJDC, which interacted with 74 different targets related to inflammation and the immune system. The CCK-8 results showed that different concentrations of SFJDC serum had no significant inhibitory effect on the viability of RAW264.7 cells. LC3-II was significantly increased after virus infection compared to the control group, while it was inhibited by different concentrations of SFJDC serum. H1N1 virus nucleocapsid protein (NP protein) was significantly reduced in the high concentration group, Interleukin-1β (IL-1β), Interleukin-6 (IL-6), Tumor Necrosis Factor-α (TNF-α), and viral M1 gene were significantly reduced compared to the H1N1 group. The integrated systemic pharmacological approach and experimental validation not only provide a precise explanation of the molecular mechanism of SFJDC in the treatment of H1N1 infection but also provide valuable clues for the development of novel drug strategies to control the H1N1 infection.