cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.17632/cybfnfwr37
title: Cascada de señalización de la insulina y la actividad física para el transporte de GLUT-4 y la captación de glucosa en el músculo esquelético

description: El músculo esquelético (ME), debido a su significativo tamaño y función, representa el tejido que más energía demanda durante la actividad física. En respuesta a esta demanda, ha desarrollado un sistema altamente especializado para almacenar energía y satisfacer sus necesidades metabólicas. Para alcanzar esta eficacia en el almacenamiento y abastecimiento de nutrientes, en particular de glucosa, el ME depende de una incorporación nutricional eficaz. La relación entre la insulina y el ejercicio ilustra un ejemplo de equilibrio complejo y de adaptación, en el que dos fuerzas reguladoras metabólicas se contraponen en contextos cambiantes. El aumento de la insulina en la sangre comunica al ME la presencia de niveles elevados de glucosa plasmática. Aunque la insulina se secreta tras la ingesta y es la principal hormona que aumenta el almacenamiento de glucosa y ácidos grasos en forma de glucógeno y triglicéridos, respectivamente, el ejercicio es una situación fisiológica que exige la movilización y oxidación de las reservas energéticas. Por lo tanto, durante la actividad física, los efectos del almacenamiento inducidos por la insulina deben mitigarse median-te la inhibición de la liberación de insulina durante el ejercicio, y la activación de los mecanismos sistémicos y locales de movilización de energía. La interacción de la insulina con su receptor da lugar a una compleja cascada de señales que promueve la captación de glucosa y la síntesis de glucógeno. Uno de los efectos más estudiados de la señalización insulínica en el ME es el incremento en la captación de la glucosa muscular. Tanto la insulina como la actividad contráctil aumentan la entrada de glucosa en el ME, proceso que involucra la translocación y fusión de vesículas que contienen el transportador de glucosa GLUT-4 en la membrana (GSV: vesículas de almacena-miento de GLUT-4). Así, los estímulos mencionados provocan el traslado de las GSV hacia la superficie celular, donde se fusionan, lo que aumenta la presencia de GLUT-4 y favorece la captación de glucosa del entorno intersticial. Este proceso de fusión se conoce como “exocitosis de GLUT-4”.Tras la actividad física, es necesario reponer las reservas de energía consumidas, en especial, el glucógeno en el músculo. El proceso se ve favorecido por un aumento de la sensibilidad a la insulina en los músculos previamente ejercitados, lo que facilita la utilización de la glucosa en la resíntesis del glucógeno. Este trabajo de revisión abarca los nuevos actores de la cascada de señalización de la insulina, el transporte de GLUT-4 y las interacciones insulina-ejercicio durante y después de la actividad física. Además, explora los efectos del entrenamiento físico regular sobre la acción de la insulina.
DOI: 10.17632/v462ccvfg8
title: Parasympathetic neurons derived from human pluripotent stem cells model human diseases and development. Wu et al.

description: Parasympathetic neurons (parasymNs) belong to the autonomic nervous system (ANS) and are critical for unconscious body responses, including rest-and-digest and calming the body. ParasymN innervation is important for organ development; and ParasymN dysfunction is a hallmark of neural diseases such as autonomic neuropathy and neurological autoimmune disease. However, human parasymN function and dysfunction is vastly understudied, due to the lack of a model system. Human pluripotent stem cell (hPSC)-derived neurons can fill this void and serve as a platform for disease modeling, drug screening, and transplantation therapy. Here, we developed a differentiation paradigm detailing, the derivation of functional human parasymNs from Schwann cell progenitors (SCP). We employ these neurons (i) to assess human ANS developmental paradigms, (ii) to model neuropathy in the genetic disorder Familial Dysautonomia (FD), (iii) to show parasymN dysfunction during SARS-CoV-2 infection, (iv) to model the autoimmune disease Sjögren’s syndrome and, (v) to show that parasymN innervation of white adipocytes during development and help mature the tissue. Our model system could become instrumental for future disease modeling and drug discovery studies as well as for human developmental studies.
DOI: 10.15468/dl.4dwnxp
title: Occurrence Download

description: A dataset containing 6610 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Anolis cristatellus Duméril & Bibron, 1837)",
 "BasisOfRecord is one of (Machine Observation, Human Observation, Observation, Literature Occurrence)",
 "HasCoordinate is true"
 ]
}

 The dataset includes 6610 records from 6 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0001444-250227182400228/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.17632/x5pj7zdnxs
title: Data Set: Improving Access to Cognitive Behavioural Therapy Groups for Postnatal Women following Partnership Work: A Service Evaluation

description: Data set from service evaluation
DOI: 10.17632/4w4ws2tsrp
title: Data For: Comparative Study of Radial Basis Function Neural Networks with Classification Methods for Urban Traffic Signal Control

description: This file contains the real-world vehicle arrivals to an isolated intersection. The first four columns represent vehicle arrivals to four lanes. The last four columns show adaptive green times for four lanes.
DOI: 10.17632/vk9zn8ktcv
title: Journal Data

description: Dataset for journal publication
DOI: 10.6084/m9.figshare.19519492.v1
title: master chart.xlsx

description: Impact of Chronic Periodontitis on Cognitive status in Type 2 Diabetes Mellitus patients less than 60 years of age.
DOI: 10.15468/dl.2s32jr
title: Occurrence Download

description: A dataset containing 22 species occurrences available in GBIF matching the query:
{
 "and" : [
 "BasisOfRecord is Specimen",
 "TaxonKey is Cyrtochilum leucopterum (Rchb.f.) Dalström"
 ]
}

 The dataset includes 22 records from 14 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0001451-250227182430271/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.6084/m9.figshare.25583520.v1
title: RNAseq data - FPKM - Maladaptive genes - WT vs AKAP12OX (14 days ISO)

description: Maladaptive Genes analysis - FPKM - WT vs AKAP12OX (14 days ISO)
DOI: 10.17632/dx7p5d2w2r
title: Data for: Surface acoustic wave generation on piezoelectric passive substrates for axisymmetric SAW motors

description: These are research data related to the submitted paper "Contributions to the development of an axisymmetric SAW motor with a stator made from non-piezoelectric material" (Journal Sensors and Actuators A). A description of all shared files can be found in the file Measurement_and_Simulation_documentation.odt.
DOI: 10.15468/dl.mjr6be
title: Occurrence Download

description: A dataset containing 55 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Cyrtochilum megalophium (Lindl.) Kraenzl."
 ]
}

 The dataset includes 55 records from 18 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0001445-250227182400228/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.6084/m9.figshare.24183591.v2
title: Supplementary_Tables.zip

description: Sepsis is a clinical syndrome of life-threatening organ dysfunction caused by a dysregulated response to infection, for which disease heterogeneity is a major obstacle to developing targeted treatments. We have previously identified gene expression-based patient subgroups (Sepsis Response Signatures: SRS) informative for outcome and underlying pathophysiology. Here we aimed to investigate the role of genetic variation in determining the host transcriptomic response and to delineate regulatory networks underlying SRS. Using genotyping and RNA-seq data on 638 adult sepsis patients, we report 16,049 independent expression (eQTLs) and 32 co-expression module (modQTLs) quantitative trait loci in this disease context. We identified significant interactions between SRS and genotype for 1,578 SNP-gene pairs, and combined transcription factor (TF) binding site information (SNP2TFBS) and predicted regulon activity (DoRothEA) to identify candidate upstream regulators. These included HIF1A and CEBPB, which were associated with progenitor and immature neutrophil subsets respectively, further implicating glycolysis and emergency granulopoiesis in SRS1. Overall, these approaches identified putative mechanistic links between host genetic variation, cell subtypes, and the individual transcriptomic response to infection. Understanding the regulatory networks underlying patient heterogeneity provides additional information for developing immunomodulatory treatments and a personalised medicine approach to treating sepsis.
DOI: 10.17632/bp64m9bf56
title: Studies on salt adaptation in Sesuvium portulacastrum (L.) L. using molecular and biotechnological approaches

description: Supplementary content of Ph.D. thesis entitled "Studies on salt adaptation in Sesuvium portulacastrum (L.) L. using molecular and biotechnological approaches" by Mr. Jayant Anant Kulkarni
This data includes following components 
Mendeley Table 1: Key findings from the metabolomic studies in different halophytes under salt stress. Findings demonstrated salinity induced metabolic regulations in halophytes.
Mendeley Table 2: Key findings from the transcriptomic studies in different halophytes under salt stress. Findings demonstrated salinity induced molecular regulations in halophytes. 
Mendeley Table 3: Categorization of detected metabolites in different functional groups after performing GC-MS based metabolite profiling in Sesuvium portulacastrum.
Mendeley Table 4: KEGG pathway enrichment analysis of altered metabolites at NR8 after performing GC-MS based metabolite profiling in Sesuvium portulacastrum.
Mendeley Table 5: KEGG pathway enrichment analysis of altered metabolites at NR24 after performing GC-MS based metabolite profiling in Sesuvium portulacastrum.
Mendeley Table 6: KEGG pathway enrichment analysis of altered metabolites at NS8 after performing GC-MS based metabolite profiling in Sesuvium portulacastrum.
Mendeley Table 7: KEGG pathway enrichment analysis of altered metabolites at NS24 after performing GC-MS based metabolite profiling in Sesuvium portulacastrum.
Mendeley Table 8: Meta-analysis of GC-MS based metabolite profiling in different halophytes under salt stress from seven studies (30 datasets). Significantly altered metabolites were identified for pathway analysis and the pathways were ranked using a cumulative pathway score (CPS). Table represents 1) Altered metabolites according to altered pathways, along with metabolite code and Log2 fold change in root and shoot. 2) Ranking of metabolic pathways according to CPS 
Mendeley Supplementary method 1: Correlation of experimental data with theoretical models.
DOI: 10.6084/m9.figshare.14371106.v1
title: Measurement data of hysteresis and backfield of IRM of gel-capsular sediment samples from Levinson-Lessing Lake and related hysteresis parameter

description: The dataset contains measurement data files from 119 gel capsule samples prepared from freeze-dried sediment of core Co1401 from the Levinson Lessing. The measurements of the hysteresis and the backfield of the IRM were performed with a Lakeshore VSM model 8604 at the University of Cologne (Germany). They were used to determine the hysteresis parameters presented here, and depicted and discussed in the associated publication on the mineral magnetic characterization of core Co1401.<br>
DOI: 10.6084/m9.figshare.25735173.v1
title: Supplemental Table S6. Differential gene expression between HIGH group and LOW group of hematological parameters.

description: Genetic and phenotypic (co)variances of hematological parameters were performed with 1,610 genotype data and 5,499 hematological parameter records from 4,543 cows, using the Average Information Restricted Maximum Likelihood method. Also, we assessed the genetic relationship among these indicators and other economically important traits in dairy cattle breeding. Finally, we carried out genome-wide association studies and candidate gene analyses, and blood samples from 21 primiparous cows were used for further validation of candidate genes through RNA sequencing analyses.
DOI: 10.17632/7knxswg9xx
title: Source data and analysis results of WMCASHC

description: Source data and analysis results of the Paper “Why do major chemical accidents still happen in China: Analysis from a process safety management perspective”
DOI: 10.6084/m9.figshare.3552282.v1
title: Appendix A. Hydrologic methods and classification.

description: Hydrologic methods and classification.
DOI: 10.6084/m9.figshare.17425454.v1
title: Kay et al 2021 data.zip

description: All data from publication "Therapeutic Effects of Hypoxic and Pro-Inflammatory Priming of Mesenchymal Stem Cell-Derived Extracellular Vesicles in Inflammatory Arthritis" in International Journal of Molecular Sciences 2021/2022
DOI: 10.17632/5mv45pj6m2
title: Bitter taste and polyphenols; beneficial physiological activity via gastrointestinal hormones

description: Recently, there has been a notable emphasis on the homeostatic regulation by taste receptors that are expressed in extra-oral cavities. Bitter receptors (type 2 taste receptors, T2Rs) are abundant in the lower gastrointestinal tract and activated by bitter compounds in food. Activation of T2R triggers the release of gastrointestinal hormones such as cholecystokinin (CCK) or incretin as glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1). These peptides regulate appetite and amount of food consumption by affecting gastrointestinal motility. Besides, incretins are also known to regulate blood glucose homeostasis through insulin secretion. Polyphenols are micronutrients commonly found in plant-based food that possess a strong bitter taste. Additionally, they are not well absorbed by the upper digestive tract and thus tend to move to the colon and get excreted in the feces. Previous epidemiological and intervention studies suggest a negative correlation between polyphenol intake and the risk of diabetes. The beneficial functions that follow the ingestion of polyphenols might be caused by the mediation of T2R, which regulates glucose tolerance and gastrointestinal motility. This review explores the relationship between bitter taste and polyphenol bioactivity to understand better the mechanisms by which polyphenols exert their health benefits.
DOI: 10.17632/jv2vf34zg2
title: Dietary sugars silence the master regulator of carbohydrate utilization in human gut Bacteroides species

description: This data corresponds to Dietary sugars silence the master regulator of carbohydrate utilization in human gut Bacteroides species. In this manuscript, we investigate the impact dietary sugar has on colonization and transcription factors in Bacteroides. These files include quantified western blots, transcript measurement by qPCR, ChIP, and in vivo competition assays. Data files are in .xlsx with biological replicates arrayed left to right with corresponding treatment data points arrayed top to bottom and each figure panel has an individual worksheet. These data were analyzed in Prism with two-way ANOVA used for all experiments with equal n or one-way for unequal n.
DOI: 10.17632/cw5jkf65sd
title: La nuova disciplina del servizio di ricerca in materia di investimenti. Conseguenze applicative in materia di imposta sul valore aggiunto. (2018)

description: La nuova disciplina del servizio di ricerca in materia di investimenti. Conseguenze applicative in materia di imposta sul valore aggiunto. (2018)
DOI: 10.17632/6fpf82rp8b
title: The HepMC3 event record library for Monte Carlo event generators

description: In high-energy physics, Monte Carlo event generators (MCEGs) are used to simulate the interactions of high energy particles. MCEG event records store the information on the simulated particles and their relationships, and thus reflect the simulated evolution of physics phenomena in each collision event. We present the HepMC3 library, a next-generation framework for MCEG event record encoding and manipulation, which builds on the functionality of its widely-used predecessors to enable more sophisticated algorithms for event-record analysis. As compared to previous versions, the event record structure has been simplified, while adding the possibility to encode arbitrary information. The I/O functionality has been extended to support common input and output formats of various HEP MCEGs, including formats used in Fortran MCEGs, the formats established by the HepMC2 library, and binary formats such as ROOT; custom input or output handlers may also be used. HepMC3 is already supported by popular modern MCEGs and can replace the older HepMC versions in many others.
DOI: 10.6084/m9.figshare.c.3933019_d4.v1
title: MOESM2 of The Gene Ontology of eukaryotic cilia and flagella

description: Additional file 2. Prokaryotic flagella-related cellular component and biological process terms in the Gene Ontology (GO). Full list of terms available in the Gene Ontology (GO) to describe cellular components and biological processes related to prokaryotic flagella and available as of January 2017. Terms are listed in 3 separate sections pertinent to cellular components, motility and general organization of the flagellum, respectively. GO ID, Gene Ontology term identifier; GO term name, Gene Ontology term descriptive label; Aspect, branch of the Gene Ontology (CC = cellular component, BP = biological process); Created/modified by cilia GO project, indicates if a term was created or modified as part of the work described in this article. All GO terms can be browsed via AmiGO ( http://amigo.geneontology.org/amigo ) or QuickGO ( http://www.ebi.ac.uk/QuickGO/ ), and the full ontology can be downloaded via http://geneontology.org/page/download-ontology .
DOI: 10.17632/d6fn8y7pc2
title: Small proteins regulate Salmonella survival inside macrophages by controlling degradation of a magnesium transporter

description: Original blots for figures in manuscript
DOI: 10.17632/nr9t27p4d9
title: Intertidal clam settlement in Washington state, USA

description: This dataset addresses the settlement rates of two non-native intertidal clam species at 8 beaches in Washington state, USA from May to September 2016-2017. Clam species were manila (Ruditapes philippinarum) and eastern soft-shell (Mya arenaria). Settlement was measured at mean tide level on shore every 2-4 weeks in mesh bags (1.5 mm mesh, 10x12 mm) filled with round gravel or crushed shell. Clams were counted that were caught on 250 micron sieve (large settlers) and, in 2016, on 150 micron mesh (small settlers). Also, in June 2017, densities of juvenile clams <20mm were measured at mean tidal elevation at each beach in five samples of 900 cm^2, 5 cm depth. Archived files include site locations and the date, site, position along transect at mean tide level, and counts of each clam species and size class. Data were used to test for spatio-temporal variation in settlement, to relate settlement timing and magnitude to local temperature and salinity, and to relate juvenile densities to settlement the previous year.
DOI: 10.15468/dl.jbg9hr
title: Occurrence Download

description: A dataset containing 54 species occurrences available in GBIF matching the query:
{
 "and" : [
 "BasisOfRecord is Specimen",
 "TaxonKey is Cyrtochilum megalophium (Lindl.) Kraenzl."
 ]
}

 The dataset includes 54 records from 17 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0001452-250227182430271/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.6084/m9.figshare.13119907.v2
title: The mRNA derived MalH sRNA contributes to alternative carbon source utilization by tuning maltoporin expression in E. coli

description: Previous high-throughput studies in Gram-negative bacteria identified a large number of 3ʹUTR fragments that potentially function as sRNAs. Here we extensively characterize the MalH sRNA. We show that MalH is a stable degradation intermediate derived from the 3ʹ end of <i>malG</i>, which is part of the maltose uptake operon transcript <i>malEFG</i>. Unlike the majority of bacterial sRNAs, MalH is transiently expressed during the transition from the exponential to the stationary growth phase, suggesting that it contributes to adaptation to changes in nutrient availability. Over-expression of MalH reduces expression of general outer membrane porins and MicA, a repressor of the high-affinity maltose/maltodextrin transporter LamB. Disrupting MalH production and function significantly reduces <i>lamB</i> accumulation when maltose is the only available carbon source, presumably due to the accumulation of the MicA repressor. We propose that MalH is part of a regulatory network that, during the transition phase, directly or indirectly promotes accumulation of high-affinity maltose transporters in the outer membrane by dampening competing pathways.
DOI: 10.6084/m9.figshare.14724732.v1
title: Data and code from: Support for an area–heterogeneity tradeoff for biodiversity in croplands

description: Tab-delimited, plain-text data files and R scripts. Please see "Metadata.txt" for details. <br> Abstract from associated paper: Rapid expansion of the human population poses a challenge for wildlife conservation in agricultural landscapes. One proposition is that we could increase biodiversity in such landscapes by increasing crop diversity. However, studies report both positive and negative effects of crop diversity on biodiversity. One possible explanation, derived from the “area–heterogeneity tradeoff hypothesis,” is that the effect of crop diversity on biodiversity depends on a tradeoff between increasing the number of crop types in a landscape and decreasing the amount of each single crop type. This should cause positive effects of increasing crop diversity at low to intermediate crop diversity and negative effects at intermediate to high crop diversity. We also proposed two factors that could change the point at which the effect of increasing crop diversity shifts from positive to negative. First, we predicted that this shift occurs at a lower crop diversity when the surrounding landscape contains less semi-natural habitat, and at a higher crop diversity when the landscape contains more semi-natural habitat. This should increase the likelihood of detecting negative effects of crop diversity when semi-natural cover is low and positive effects when it is high. Second, we predicted that the shift from a positive to negative effect occurs at a lower crop diversity when it is measured locally than when it is measured at greater distances from the site, making detection of negative crop diversity effects more likely when measurements are at local extents. We tested these predictions using data on the biodiversity of herbaceous plants, butterflies, syrphid flies, woody plants, bees, carabid beetles, spiders, and birds at 221 crop field edges in Eastern Ontario, Canada. We found support for an area–crop diversity tradeoff. Semi-natural cover and measurement extent influenced the biodiversity–crop diversity relationship, with positive effects when semi-natural cover was high, and negative effects when semi-natural cover was low and when crop diversity was measured at local extents. The results suggest that policies/guidelines designed to increase crop diversity will not benefit biodiversity in the landscapes where conservation action is most urgently needed, i.e. in landscapes with high agricultural use and low semi-natural cover.