cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.12682058.v1
title: Supplementary Material for: Effects of White Matter Hyperintensities on 90-Day Functional Outcome after Large Vessel and Non-Large Vessel Stroke

description: <b><i>Introduction:</i></b> White matter hyperintensity (WMH) burden is a critically important cerebrovascular phenotype related to the diagnosis and prognosis of acute ischemic stroke. The effect of WMH burden on functional outcome in large vessel occlusion (LVO) stroke has only been sparsely assessed, and direct LVO and non-LVO comparisons are currently lacking. <b><i>Material and Methods:</i></b> We reviewed acute ischemic stroke patients admitted between 2009 and 2017 at a large healthcare system in the USA. Patients with LVO were identified and clinical characteristics, including 90-day functional outcomes, were assessed. Clinical brain MRIs obtained at the time of the stroke underwent quantification of WMH using a fully automated algorithm. The pipeline incorporated automated brain extraction, intensity normalization, and WMH segmentation. <b><i>Results:</i></b> A total of 1,601 acute ischemic strokes with documented 90-day mRS were identified, including 353 (22%) with LVO. Among those strokes, WMH volume was available in 1,285 (80.3%) who had a brain MRI suitable for WMH quantification. Increasing WMH volume from 0 to 4 mL, age, female gender, a number of stroke risk factors, presence of LVO, and higher NIHSS at presentation all decreased the odds for a favorable outcome. Increasing WMH above 4 mL, however, was not associated with decreasing odds of favorable outcome. While WMH volume was associated with functional outcome in non-LVO stroke (<i>p</i> = 0.0009), this association between WMH and functional status was not statistically significant in the complete case multivariable model of LVO stroke (<i>p</i> = 0.0637). <b><i>Conclusion:</i></b> The burden of WMH has effects on 90-day functional outcome after LVO and non-LVO strokes. Particularly, increases from no measurable WMH to 4 mL of WMH correlate strongly with the outcome. Whether this relationship of increasing WMH to worse outcome is more pronounced in non-LVO than LVO strokes deserves additional investigation.
DOI: 10.6084/m9.figshare.12682067.v1
title: Fruit fly foraging data in optogenetic closed loop set-up

description: The Gr5a-Chr2 is a mat file structure array that stores X and Y position tracking and stimulation events. When loaded into the matlab workspace as FD file It has multiple fields. First is the P - probability conditions [0.05, 0.15, 0.3, 0.45, 0.6, 0.75, 1] that correspond to one sided stimulation for indexes from 1-7. indexes 8-9 correspond to two sided stimulaton with 0.05 and 0.15. index 10 corresponds to no stimulation periods.The P structure array stores multiple variables: like X and Y position, timestamps that animal spends in Trigger zone (InTZ) and into the Reset zone (InRZ), Returns, Trigger events and etc. Variable Arena has two cell arrays for each animal and each session that correspond to the events for the left and right side. The mat file GeneticControls has the same structure as Gr5a-ChR2 file and it stores probability stimulation data for genetic control lines. For LexAop-Chrimson/+ flies 0.05 and for Gr5a-LexA/+ 0.05, 0.3 and 0.6 probability stimulation data.
DOI: 10.6084/m9.figshare.12681986
title: Supplementary Material for: Psychopathological Networks in Cognitive-Behavioral Treatments for Binge-Eating Disorder

description: <b><i>Introduction:</i></b> Network approaches to psychopathology posit that mental disorders emerge from interrelated symptoms, and thus connectivity among symptoms are assumed to negatively predict the treatment response and decrease with efficacious treatment. <b><i>Objective:</i></b> This study uniquely sought to elucidate the network structure, its change, and its predictive value in cognitive-behavioral therapy (CBT) for binge-eating disorder (BED). <b><i>Methods:</i></b> In a multicenter randomized trial of face-to-face and Internet-based guided self-help CBT, 178 individuals with full syndrome and subsyndromal BED, eating disorder and general psychopathology, and body mass index (BMI) were subjected to Gaussian Graphical Network and Exploratory Graph Analyses before and after treatment and at 6-month follow-up. <b><i>Results:</i></b> At pretreatment, 3 network communities of: eating disorder psychopathology; general psychopathology; and restraint and BMI were identified, with the latter community included in the first thereafter. Eating disorder-related impairment and self-esteem were the most central symptoms, while BMI and binge eating had the lowest centrality. Network connectivity significantly increased from pre- to posttreatment, with the greatest increases in strength centrality found in binge eating and shape concern, but it did not predict remission from binge eating. <b><i>Conclusions:</i></b> With decreasing symptom severity, CBT resulted in a greater integration and connectivity of the psychopathology network in BED, suggesting an increased patient understanding of relations between binge eating and other symptoms. Network connectivity was not a negative prognostic indicator of treatment outcome. These results indicate a need for further research on the predictive value of network variables in the explanation of therapeutic change for patients with BED.
DOI: 10.6084/m9.figshare.12681983
title: Multi-relational real world manufacturing process data (FCUP, CMF)

description: The dataset comes from a real world manufacturing process of a Critical Manufacturing business partner. The manufacturing process is monitored via a IoT system. The dataset has been carefully anonymized due to privacy concerns, for more details on how this process was conducted see the accompanying thesis.<br>In the case of the process that generates this data eight different readings are taken each time a particular tool is used. Eventually once a tool begins underperforming, it is retired and therefore does not again again appear in the dataset. We believe that this dataset may be used to estimate and predict tool longevity, as it likely presents time dependent covariates as such be of use to the research of multilevel survival analysis or predictive maintenance models.<br><br><br>Name |Type |Description--------------------------|---------------------|---------OperationEndTime |Numerical |Difference in seconds from the first operation in the dataset.ToolId |Numerical Key |The tool used. It’s value is unique to each different tool in the dataset.Machine |Numeric |A categorical variable, representing the machine that used the tool. It’s value is unique to each different machine in the dataset.Process |Numeric |A categorical variable, representing the process that used the tool. It’s value is unique to each different process in the dataset.P1DataPoint1 |Numeric |A concrete value for a reading of parameter one.P1DataPoint2 |Numeric |A concrete value for an error metric associated with the process that generated the value present on P1DataPoint1.P2DataPoint1 |Numeric |A concrete value for a reading of parameter two.P2DataPoint2 |Numeric |A concrete value for an error metric associated with the process that generated the value present on P1DataPoint2.... |... |...P8DataPoint1 |Numeric |A concrete value for a reading of parameter eight.P8DataPoint2 |Numeric |A concrete value for an error metric associated with the process that generated the value present on P1DataPoint8.
DOI: 10.6084/m9.figshare.12682046.v1
title: Supplementary Material for: The Association of Low Hemoglobin Levels with IgA Nephropathy Progression: A Two-Center Cohort Study of 1,828 Cases

description: <b><i>Aim:</i></b> To investigate the relationship between hemoglobin levels and the progression of IgA nephropathy (IgAN). <b><i>Methods:</i></b> In a two-center cohort of 1,828 cases with biopsy-proven IgAN, we examined the association of hemoglobin levels with the primary outcome of a composite of all-cause mortality or kidney failure defined as a 40% decline in eGFR, or ESKD (defined as eGFR &lt;15 mL/min/1.73 m<sup>2</sup> or need for kidney replacement therapy including hemodialysis, peritoneal dialysis, or kidney transplantation), or the outcome of kidney failure, assessed using Cox and logistic regression models, respectively, with adjustment for confounders. <b><i>Results:</i></b> At baseline, mean age, eGFR, and hemoglobin levels were 33.75 ± 11.03 years, 99.70 ± 30.40 mL/min/1.73 m<sup>2</sup>, and 123.47 ± 18.36 g/L, respectively. During a median of approximately 7-year follow-up, 183 cases reached the composite outcome. After adjustment for demographic and IgAN-specific covariates and treatments, a lower quartile of hemoglobin was nonlinearly associated with an increased risk of the primary outcome or kidney failure in the Cox proportional hazards models (primary outcome: HR for quartile 3 vs. 4, 1.37; 95% CI, 0.83–2.25; HR for quartile 2 vs. 4, 1.18; 95% CI, 0.68–2.07; HR for quartile 1 vs. 4, 1.91; 95% CI, 1.15–3.17; kidney failure: HR for quartile 3 vs. 4, 1.39; 95% CI, 0.84–2.31; HR for quartile 2 vs. 4, 1.20; 95% CI, 0.68–2.11; HR for quartile 1 vs. 4, 1.83; 95% CI, 1.09–3.07) in the fully adjusted model. Then, hemoglobin levels were transformed to a binary variable for fitting the model according to the criteria for anemia of 110 g/L in the women and 120 g/L in men in China. The participants in the anemia group had an increased risk of developing outcomes compared with the nonanemia group in both genders (primary outcome: male: HR, 1.64; 95% CI, 1.01–2.68; female: HR, 1.68; 95% CI, 1.02–2.76; kidney failure: male: HR, 1.60; 95% CI, 0.97–2.64; female: HR, 1.58; 95% CI, 0.95–2.61) in the fully adjusted model. <b><i>Conclusions:</i></b> A low level of hemoglobin was nonlinearly associated with IgAN progression. The anemic IgAN patients presented a higher risk of developing poor outcomes compared with the nonanemic patients.
DOI: 10.6084/m9.figshare.12681938
title: Supplementary Material for: Patient Characteristics and Outcomes of Relapsed/Refractory Multiple Myeloma in Patients Treated with Proteasome Inhibitors in Germany

description: <b><i>Introduction:</i></b> Real-world data reflects treatments and outcomes in clinical practice in contrast with controlled clinical trials. This study evaluates real-life multiple myeloma (MM) patients receiving proteasome inhibitor (PI)-based treatments in the second or third therapy line in 2017 in Germany. <b><i>Methods:</i></b> This is a retrospective chart review on adult relapsed/refractory MM patients treated with ≥1 dose of a PI-based regimen in either the second or the third line of therapy. Participating physicians had ≥3 years of clinical experience in treating symptomatic MM patients and used PI according to the label. <b><i>Results:</i></b> Distinct patient profiles for each PI-based regimen emerged. Younger, fitter, transplant-eligible patients received novel PI triplets such as carfilzomib in combination with lenalidomide and dexamethasone (KRd) or IRd. Patients receiving lenalidomide in first-line therapy mostly received lenalidomide-free regimens in second-line therapy. In high-risk patients, no clear treatment patterns could be ascertained. The complete response rates were highest with KRd (13.0%), followed by carfilzomib in combination with dexamethasone (Kd) (5.7%) and bortezomib (4.8%). The very good partial response rates were highest with IRd (76.9%), followed by KRd (53.7%), Kd (25.7%), and bortezomib (20.5%). None of the KRd- or IRd-treated patients responded below a partial response. <b><i>Discussion/Conclusion:</i></b> Clear patient profiles for each PI type were observed. In second-line therapy, younger, fitter, transplant-eligible patients received novel-PI-based triplets, e.g., KRd or IRd. Patients treated with lenalidomide in first-line therapy mostly received lenalidomide-sparing regimens in second-line therapy. In high-risk patients no clear treatment patterns could be ascertained due to the limited sample size.
DOI: 10.25399/unisadata.12681830
title: Report on high performance work practices (HPWP) in South African companies (2020)

description: This report provides the results of a survey of South African companies which pertain to the application of high performance work practices (HPWPs) in their organisations. The report provides an overview of the findings. The basis of the survey was a questionnaire completed by the financial, marketing and human resource managers of the companies that participated in the research. The report reflects the companies’ policies as at 2016, affording the companies an opportunity to benchmark themselves against other South African organisations and identify trends in human resource management practices.
DOI: 10.6084/m9.figshare.12681824
title: Gabay & Weinstein - Spirituality, Emotional Labor, productivity [312 subjets].csv

description: Gabay & Weinstein: Spirituality, Emotional Labor, productivity [312 subjects]
DOI: 10.25399/unisadata.12681830.v1
title: Report on high performance work practices (HPWP) in South African companies (2020)

description: This report provides the results of a survey of South African companies which pertain to the application of high performance work practices (HPWPs) in their organisations. The report provides an overview of the findings. The basis of the survey was a questionnaire completed by the financial, marketing and human resource managers of the companies that participated in the research. The report reflects the companies’ policies as at 2016, affording the companies an opportunity to benchmark themselves against other South African organisations and identify trends in human resource management practices.
DOI: 10.6084/m9.figshare.12681305
title: Supplementary Material for: Higher Eosinophils Predict Death-Censored Technique Failure in Peritoneal Dialysis Patients

description: <b><i>Introduction:</i></b> Eosinophilia (eosinophil fraction of leukocytes &gt;5%), an indicative parameter for bioincompatibility in various circumstances, is well established in hemodialysis. However, change in eosinophil count (EOC) and its association with death-censored technique failure among peritoneal dialysis (PD) patients remain unclear. <b><i>Methods:</i></b> We compared eosinophils before and after PD initiation among 1,432 eligible continuous ambulatory PD patients regularly followed up in our PD center during 2007–2018. Risk factors of early-stage eosinophilia were examined by the logistic regression test. The relationship of early-stage eosinophilia and EOC with death-censored technique failure was examined using the Cox proportional hazards model for overall patients and for men and women separately. <b><i>Results:</i></b> After PD initiation, the EOC and percentage of patients with eosinophilia were significantly increased compared with baseline. Being male (odds ratio [OR]: 2.26; 95% confidence interval [CI]: 1.55–3.31; <i>p</i> &lt; 0.001) and higher EOC at baseline (100 cells/μL increase, OR: 1.62; 95% CI: 1.45–1.82; <i>p</i> &lt; 0.001) were risk factors of early-stage eosinophilia after PD initiation. During follow-up, 204 death-censored technique failures were recorded. In fully adjusted models, each with 100 cells/μL increase in EOC, the adjusted hazard ratios (HRs) of technique failure were 1.11 (95% CI: 1.03–1.20; <i>p</i> = 0.009) in the whole cohort, 1.29 (95% CI: 1.10–1.51; <i>p</i> = 0.002) in women, and 1.07 (95% CI: 0.97–1.17; <i>p</i> = 0.196) in men. Eosinophilia was significantly associated with the risk of technique failure for women (HR: 2.24; 95% CI: 1.07–4.70; <i>p</i> = 0.033), which was especially significant for women aged &lt;55 years (HR: 7.61; 95% CI: 1.88–30.90; <i>p</i> = 0.005). <b><i>Conclusion:</i></b> EOC was increased significantly after PD initiation, and increased numbers of eosinophils were associated with higher death-censored technique failure in PD patients, especially women.
DOI: 10.6084/m9.figshare.12681419
title: Extended data for Emerald Open Research

description: This extended data is linked to the Emerald Open Research Article titled: The ‘building paradox’: research on building-related environmental effects requires global visibility and attention
DOI: 10.6084/m9.figshare.12681305.v1
title: Supplementary Material for: Higher Eosinophils Predict Death-Censored Technique Failure in Peritoneal Dialysis Patients

description: <b><i>Introduction:</i></b> Eosinophilia (eosinophil fraction of leukocytes &gt;5%), an indicative parameter for bioincompatibility in various circumstances, is well established in hemodialysis. However, change in eosinophil count (EOC) and its association with death-censored technique failure among peritoneal dialysis (PD) patients remain unclear. <b><i>Methods:</i></b> We compared eosinophils before and after PD initiation among 1,432 eligible continuous ambulatory PD patients regularly followed up in our PD center during 2007–2018. Risk factors of early-stage eosinophilia were examined by the logistic regression test. The relationship of early-stage eosinophilia and EOC with death-censored technique failure was examined using the Cox proportional hazards model for overall patients and for men and women separately. <b><i>Results:</i></b> After PD initiation, the EOC and percentage of patients with eosinophilia were significantly increased compared with baseline. Being male (odds ratio [OR]: 2.26; 95% confidence interval [CI]: 1.55–3.31; <i>p</i> &lt; 0.001) and higher EOC at baseline (100 cells/μL increase, OR: 1.62; 95% CI: 1.45–1.82; <i>p</i> &lt; 0.001) were risk factors of early-stage eosinophilia after PD initiation. During follow-up, 204 death-censored technique failures were recorded. In fully adjusted models, each with 100 cells/μL increase in EOC, the adjusted hazard ratios (HRs) of technique failure were 1.11 (95% CI: 1.03–1.20; <i>p</i> = 0.009) in the whole cohort, 1.29 (95% CI: 1.10–1.51; <i>p</i> = 0.002) in women, and 1.07 (95% CI: 0.97–1.17; <i>p</i> = 0.196) in men. Eosinophilia was significantly associated with the risk of technique failure for women (HR: 2.24; 95% CI: 1.07–4.70; <i>p</i> = 0.033), which was especially significant for women aged &lt;55 years (HR: 7.61; 95% CI: 1.88–30.90; <i>p</i> = 0.005). <b><i>Conclusion:</i></b> EOC was increased significantly after PD initiation, and increased numbers of eosinophils were associated with higher death-censored technique failure in PD patients, especially women.
DOI: 10.6084/m9.figshare.12681419.v1
title: Extended data for Emerald Open Research

description: This extended data is linked to the Emerald Open Research Article titled: The ‘building paradox’: research on building-related environmental effects requires global visibility and attention
DOI: 10.6084/m9.figshare.12681152
title: GSM1464539_Tbx3N_NBirA-bfTbx3.bigwig

description: UCSC
DOI: 10.6084/m9.figshare.12681152.v1
title: GSM1464539_Tbx3N_NBirA-bfTbx3.bigwig

description: UCSC
DOI: 10.6084/m9.figshare.12680885
title: Forcing classification

description: This is the classification of forces associated with "Forcing the issue: Little psychological influence in a magician's paradigm". Some forces use a combination of methods. Each force was classified by the author, they are therefore somewhat subjective.
DOI: 10.6084/m9.figshare.12681110
title: Supplementary Material for: An Integrated TK-TD Model for Evaluation of <b><i>Radix Aconitikusnezoffii</i></b> (RAK)

description: <b><i>Objective:</i></b> An integrated TK-TD model with indirect response to toxicity was established using ADAPT 5 to evaluate abnormal heart rate (HR) and QT interval changes caused by <i>Radix Aconitikusnezoffii</i> (RAK). <b><i>Methods:</i></b> Plasma samples were collected from male SD rats, which were divided into the blank and RAK groups. HR and QT interval indicators were recorded. Four alternative TK models were analyzed, and the best fitting model was determined. An indirect toxicodynamics model was selected, and the relationship of plasma concentration-time-toxicity was linked by Hill’s equation. <b><i>Results:</i></b> A 1-compartment linear first-order elimination kinetic model with the biophase model – an indirect toxic effect response model – best described the data. The high-dose QT interval was evaluated. Model simulation with the ML method showed that the fitting values of 0–15 h all fell within the confidence interval (95%). AMOS analysis showed that almost all the load factor of the variable was &gt;0.7, and the χ<sup>2</sup> value was 4.169 indicating a significant difference. Load factor (correlation coefficient) between the HR and QT intervals was −0.965, indicating negative correlation. <b><i>Conclusions:</i></b> The integrated TK-TD model with linear atrioventricular first-order elimination kinetics and indirect response represents a novel mathematical method to evaluate drug-induced changes in HR and QT.
DOI: 10.6084/m9.figshare.12680885.v1
title: Forcing classification

description: This is the classification of forces associated with "Forcing the issue: Little psychological influence in a magician's paradigm". Some forces use a combination of methods. Each force was classified by the author, they are therefore somewhat subjective.
DOI: 10.6084/m9.figshare.12680828
title: S Figure 1. Immunoprofiling of HUVEC-C.

description: Immunoprofiling of markers of LEC in HUVEC-C.
DOI: 10.6084/m9.figshare.12680828.v1
title: S Figure 1. Immunoprofiling of HUVEC-C.

description: Immunoprofiling of markers of LEC in HUVEC-C.
DOI: 10.6084/m9.figshare.12680816.v1
title: FOS improved intestinal dysfunction in fatigue mice

description: FOS improved intestinal dysfunction in fatigue mice.<br>
DOI: 10.6084/m9.figshare.12680816.v2
title: FOS improved intestinal dysfunction in fatigue mice

description: FOS improved intestinal dysfunction in fatigue mice.<br>
DOI: 10.6084/m9.figshare.12680816.v3
title: FOS improved intestinal dysfunction in fatigue mice

description: FOS improved intestinal dysfunction in fatigue mice.<br>
DOI: 10.6084/m9.figshare.12680677
title: Additional file 1 of Comparison of Bayesian and frequentist methods for prevalence estimation under misclassification

description: Additional file 1 Linear regression analysis. Regression analysis using linear models with the prevalence point estimate’s estimation error as dependent variable and all z-transformed statistical and design variables π ~ , Se ~ , Sp ~ , n , n Se , n Sp $\left(\widetilde{\pi}, \widetilde{Se}, \widetilde{Sp}, {n}, n_{Se}, n_{Sp}\right)$ as well as first-order interactions as independent variables, conducted for both the Rogan-Gladen estimator and the Bayesian estimator.
DOI: 10.6084/m9.figshare.12680668
title: Additional file 2 of Enhancer prediction in the human genome by probabilistic modelling of the chromatin feature patterns

description: Additional file 2 ENCODE accession numbers of files and datasets with direct web links. This file contains the Supplementary Tables S3–S5. The ENCODE accession numbers of the files and datasets analysed in this study, as well as the direct links to download the K562 cell line data and the GM12878 cell line data are provided as Table S3 and Table S4, respectively. Table S5 provides the web link to the GENCODE annotation file employed in the study as well as the ENCODE accession numbers to the blacklisted genomic regions. Tables S3–S5 provide also additional information such as assay, experiment target, data producing laboratory, and the Gene Expression Omnibus (GEO) sample accession numbers. Excel (.xlsx) file of size 66.2 kB.
DOI: 10.6084/m9.figshare.12680677.v1
title: Additional file 1 of Comparison of Bayesian and frequentist methods for prevalence estimation under misclassification

description: Additional file 1 Linear regression analysis. Regression analysis using linear models with the prevalence point estimate’s estimation error as dependent variable and all z-transformed statistical and design variables π ~ , Se ~ , Sp ~ , n , n Se , n Sp $\left(\widetilde{\pi}, \widetilde{Se}, \widetilde{Sp}, {n}, n_{Se}, n_{Sp}\right)$ as well as first-order interactions as independent variables, conducted for both the Rogan-Gladen estimator and the Bayesian estimator.