cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.4123107.v1
title: Nutrition of infants and young children (one to three years) and its effect on later health: A systematic review of current recommendations (EarlyNutrition project)

description: <b>Background</b>. EarlyNutrition (www.project-earlynutrition.eu) is an international research project investigating the effects of early nutrition on metabolic programming. <b>Objective</b>. To summarize, by performing a systematic review, current standards, recommendations, guidelines, and regulations (hereafter, referred to as documents) on the nutrition of children up to three years of age. Special emphasis was placed on long-term effects of early nutrition, such as the risk of cardiovascular disease, hypertension, overweight, obesity, metabolic syndrome, diabetes, or glucose intolerance. <b>Methods</b>. MEDLINE, selected databases, and websites were searched for documents published between 2008 and January 2013. <b>Results</b>. Forty two documents met the inclusion criteria. The strongest and most consistent evidence for a protective, long-term effect was documented for breastfeeding. Also, limiting the intake of sodium and rapidly absorbed carbohydrates, use of a specific meal pattern, reducing the consumption of saturated fatty acids by replacing them with polyunsaturated fatty acids, and lowering the intake of trans fatty acids, seems beneficial. Many documents did not evaluate long-term outcomes of interest to us, or reported insufficient or imprecise data. Inconsistency in recommendations for some outcomes and research gaps were identified. <b>Conclusions</b>. Our findings may serve as a helpful tool in planning further research, preventive actions against important diet-related diseases, and guidelines improvement.
DOI: 10.6084/m9.figshare.4123110.v1
title: The Discrete Regime of Flame Propagation in Metal Particulate Clouds

description: Flame propagation in lean suspensions of nonvolatile fuels (aluminum and iron) in oxidizing atmospheres is experimentally investigated. Suspensions of micron-sized fuel particles were dispersed in glass tubes using a flow of oxygen/argon mixture, and flame propagation into a quiescent mixture was observed via a variety of techniques. An independence of flame speed on oxygen concentration (from 15% to 30% oxygen in argon) was observed for the suspensions of aluminum particulates. This result is found to be consistent with theoretical estimations of the relative magnitudes of the particle combustion time and the inter-particle heat diffusion time, suggesting that flame propagation through the aluminum suspensions occurs in a regime controlled by the spatial discreteness of the multiphase medium. Experiments with iron exhibited the expected square root dependence of flame speed on oxygen concentration (from 15% to 60% oxygen in argon), demonstrating that propagation in this mixture is in the classical, continuum regime of thermal flames. The aluminum mixtures also exhibited an array of flame instabilities, including a pulsating oscillation that is theoretically predicted for mixtures with a high Lewis number, although acoustic interactions with the flame tube could not be ruled out in influencing the pulsations. The result that lean aluminum flames propagate in a discrete regime suggests that the statistical nature of the particulate suspensions will have a significant influence on flame propagation, giving rise to percolation-like behavior seen in previous computational simulations of reactive waves in discrete media.
DOI: 10.7910/dvn/v1rjpf/tocevn
title: cbb20171124_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.4123080
title: Genome - Capsaspora owczarzaki (v2)

description: Capsaspora owczarzaki's genome assembly and annotation. VERSION 2<br><strong>-Hiroshi Suga</strong>, Zehua Chen, <strong>Alex de Mendoza</strong>, <strong>Arnau Sebé-Pedrós</strong>, Matthew W. Brown, Eric Kramer, Martin Carr, Pierre Kerner, Michel Vervoort, <strong>Núria Sánchez-Pons</strong>, <strong>Guifré Torruella</strong>, <strong>Romain Derelle</strong>, Gerard Manning, B. Franz. Lang, Carsten Russ, Brian J. Haas, Andrew J. Roger, Chad Nusbaum & <strong>Iñaki Ruiz-Trillo</strong>. (2013)<br><em>The Capsaspora genome reveals a complex unicellular prehistory of animals.</em><br><em><strong>Nature Communications</strong> 4: 2325 doi: 10.1038/ncomms3325 (2013).</em><br>www.multicellgenome.com
DOI: 10.6084/m9.figshare.4123083
title: Supplementary Material for: Neurodevelopmental Outcome in High-Risk Congenital Diaphragmatic Hernia Patients: An Appeal for International Standardization

description: <br><strong><em>Background:</em></strong> Since mortality in congenital diaphragmatic hernia (CDH) is decreasing, morbidity such as neurodevelopmental outcome is becoming increasingly important. <b><i>Objectives:</i></b> We evaluated neurodevelopmental outcome in high-risk CDH patients treated according to the CDH EURO Consortium standardized treatment protocol. <b><i>Methods:</i></b> This observational, prospective cohort study was conducted in two European centers. Neurodevelopment of 88 patients (Rotterdam n = 49; Rome n = 39) was assessed at 12 and 24 months with the Bayley Scales of Infant Development (BSID)-II-NL (Rotterdam) or BSID-III (Rome). Data of the centers were analyzed separately. <b><i>Results:</i></b> Cognition was normal in 77.8% of children from Rotterdam and in 94.8% from Rome at 12 months, and in 70.7 and 97.4%, respectively, at 24 months. Motor function was normal in 64.3% from Rotterdam and in 81.6% from Rome at 12 months and in 45.7 and 89.8%, respectively, at 24 months. Longer length of hospital stay (LoS) was associated with worse cognitive outcome and motor function; LoS, low socioeconomic status, and ethnicity were associated with lower cognition. <b><i>Conclusions:</i></b> At 2 years, most CDH patients have normal cognition, but are at risk for motor function delay. Due to differences in outcomes between centers, careful interpretation is needed before conclusions can be drawn for other centers. Future multicenter collaboration should not only focus on standardization of postnatal care, but also on international standardization of follow-up to identify risk factors and thereby reduce morbidity.
DOI: 10.6084/m9.figshare.4123077
title: Supplementary Material for: Epidemiology of Intracranial Haemorrhages Associated with Vitamin K Antagonist Oral Anticoagulants in Spain: TAC Registry

description: <br><strong><em>Background:</em></strong> Vitamin K antagonist oral anticoagulants (VKA-OACs) are effective for primary and secondary prevention of embolic events. The rate of haemorrhagic neurological complications in patients admitted to neurology departments in Spain is not yet known. <b><i>Aims:</i></b> We aimed to determine the clinical and epidemiological characteristics of patients with intracranial haemorrhage secondary to VKA-OACs as well as the incidence of this severe complication. <b><i>Methods:</i></b> We conducted a retrospective, descriptive, multi-centre study using information from the medical records of all patients admitted to neurology departments, diagnosed with spontaneous intracranial haemorrhage, and treated with VKA-OACs within a 1-year period. We collected demographic and care data from centres, patients' medical records [demographic data, medical history, haemorrhage origin, vascular risk factors, concomitant treatment, and National Institutes of Health Stroke Scale (NIHSS) scores], and patients' outcome at 3 months [independence (modified Rankin Scale score &lt;3) and mortality rate]. <b><i>Results:</i></b> Twenty-one hospitals serving a population of 8,155,628 inhabitants participated in the study. The total number of cases was 235, the mean age was 78.2 (SD 9.4) years, and the baseline NIHSS score was 11.6 (SD 9.5; median 9; interquartile range 14). The VKA-OACs used were acenocoumarol in 95.3% (224 patients) and warfarin in 4.7% (11 patients). The haemorrhage origin was deep in 29.8%, lobar in 25.5%, intraventricular in 11.5%, extensive in 17.4% (&gt;100 ml), cerebellar in 12.3%, and in the brainstem in 3.4%. The international normalised ratio was within therapeutic ranges at admission (according to indication) in 29.4% (69 patients). The global incidence (cases per 100,000 inhabitants per year) is 2.88. The in-hospital mortality rate was 40%, and 24.3% of the patients were independent at 3 months, while the mortality at 3 months was 42.6%. <b><i>Conclusion:</i></b> VKA-OAC treatment is associated with a large percentage of all cases of spontaneous intracranial haemorrhage, an event leading to high dependence and mortality rates.
DOI: 10.7910/dvn/v1rjpf/h03hu2
title: cbb20170524_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.4123080.v1
title: Genome (v2) - Capsaspora owczarzaki

description: Capsaspora owczarzaki's genome assembly and annotation. VERSION 2<strong><br></strong><strong><br></strong><strong>-Hiroshi Suga</strong>, Zehua Chen, <strong>Alex de Mendoza</strong>, <strong>Arnau Sebé-Pedrós</strong>, Matthew W. Brown, Eric Kramer, Martin Carr, Pierre Kerner, Michel Vervoort, <strong>Núria Sánchez-Pons</strong>, <strong>Guifré Torruella</strong>, <strong>Romain Derelle</strong>, Gerard Manning, B. Franz. Lang, Carsten Russ, Brian J. Haas, Andrew J. Roger, Chad Nusbaum & <strong>Iñaki Ruiz-Trillo</strong>. (2013)<br><em>The Capsaspora genome reveals a complex unicellular prehistory of animals.</em><br><em><strong>Nature Communications</strong> 4: 2325 doi: 10.1038/ncomms3325 (2013).</em>
DOI: 10.7910/dvn/v1rjpf/routvd
title: cbb20170526_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.4123074
title: Supplementary Material for: Hsp27 Acts as a Master Molecular Chaperone and Plays an Essential Role in Hepatocellular Carcinoma Progression

description: <strong><em>Aims:</em></strong> Hsp27, a master molecular chaperone, plays an important role in cancer. However, the specific co-chaperones that partner with Hsp27 and the role of Hsp27 in hepatocellular carcinoma (HCC) are not fully enumerated. The present study focuses on the role of Hsp27 in HCC and explores its potential co-chaperones in HCC development. <b><i>Methods:</i></b> Gene overexpression or knockdown was used to observe the role of Hsp27 in HCC. Co-immunoprecipitation and mass spectrometry were used to explore apoptosis resistance by regulating multiple co-chaperones of Hsp27. Hsp27 protein-protein interaction (PPI) networks were constructed by the MetaCore software. <b><i>Results:</i></b> Hsp27 was upregulated in HCC tissues, and Hsp27 overexpression significantly facilitated formation of HCC cell colony and invasion in normoxia and tolerance in hypoxia by interacting with HIF-1α. Next, the analysis of microarrays revealed that Hsp27 regulated several cellular signaling pathways, including Wnt, ErbB and TGF-β signaling. Moreover, we characterized the Hsp27 PPI map, which indicated that Hsp27 along with its co-chaperones formed different complexes and exerts transcription regulation activity by activating sp1, c-Myc, p53 and ESR1. <b><i>Conclusions:</i></b> Hsp27 along with its co-chaperones was related to the development of HCC by regulating multiple signaling pathways, and drugs that target Hsp27 along with its co-chaperones may be a potential therapy for HCC.<br>
DOI: 10.6084/m9.figshare.4123080.v3
title: Genome - Capsaspora owczarzaki (v2)

description: Capsaspora owczarzaki's genome assembly and annotation. VERSION 2<br><strong>-Hiroshi Suga</strong>, Zehua Chen, <strong>Alex de Mendoza</strong>, <strong>Arnau Sebé-Pedrós</strong>, Matthew W. Brown, Eric Kramer, Martin Carr, Pierre Kerner, Michel Vervoort, <strong>Núria Sánchez-Pons</strong>, <strong>Guifré Torruella</strong>, <strong>Romain Derelle</strong>, Gerard Manning, B. Franz. Lang, Carsten Russ, Brian J. Haas, Andrew J. Roger, Chad Nusbaum & <strong>Iñaki Ruiz-Trillo</strong>. (2013)<br><em>The Capsaspora genome reveals a complex unicellular prehistory of animals.</em><br><em><strong>Nature Communications</strong> 4: 2325 doi: 10.1038/ncomms3325 (2013).</em><br>www.multicellgenome.com
DOI: 10.7910/dvn/v1rjpf/hegvtd
title: cbb20171102_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.4122924
title: Supplementary Material for: Microspectroscopic Confocal Raman and Macroscopic Biophysical Measurements in the in vivo Assessment of the Skin Barrier: Perspective for Dermatology and Cosmetic Sciences

description: <br>Skin barrier function, confined to the stratum corneum, is traditionally evaluated using established, noninvasive biophysical methods like transepidermal water loss, capacitance and conductance. However, these methods neither measure skin molecular composition nor its structure, hindering the actual causes of skin barrier change or impairment. At the same time, confocal Raman microspectroscopy (CRS) can directly measure skin molecular composition and structure and has proven itself to be a powerful technique for biomolecular analysis. The aims of this literature review were to evaluate noninvasive biophysical methods in view of CRS and to outline a direction towards more specific and informative skin measurement methods. We address this by investigating, for the first time, the relation between in vivo assessment of the skin barrier using indirect biophysical methods and the actual skin composition and structure as given by CRS, and emphasize the high potential of CRS for dermatology and cosmetic sciences. CRS acceptance in these fields will require close collaboration between dermatologists, skin scientists and spectroscopy experts towards simplifying the technology and creating robust, rapid, easy-to-use and less expensive CRS applications.
DOI: 10.6084/m9.figshare.4123080.v2
title: Genome - Capsaspora owczarzaki (v2)

description: Capsaspora owczarzaki's genome assembly and annotation. VERSION 2<br><strong>-Hiroshi Suga</strong>, Zehua Chen, <strong>Alex de Mendoza</strong>, <strong>Arnau Sebé-Pedrós</strong>, Matthew W. Brown, Eric Kramer, Martin Carr, Pierre Kerner, Michel Vervoort, <strong>Núria Sánchez-Pons</strong>, <strong>Guifré Torruella</strong>, <strong>Romain Derelle</strong>, Gerard Manning, B. Franz. Lang, Carsten Russ, Brian J. Haas, Andrew J. Roger, Chad Nusbaum & <strong>Iñaki Ruiz-Trillo</strong>. (2013)<br><em>The Capsaspora genome reveals a complex unicellular prehistory of animals.</em><br><em><strong>Nature Communications</strong> 4: 2325 doi: 10.1038/ncomms3325 (2013).</em><br>www.multicellgenome.com
DOI: 10.6084/m9.figshare.4122558
title: Supplementary Material for: Prey-Capture Strategies of Fish-Hunting Cone Snails: Behavior, Neurobiology and Evolution

description: The venomous fish-hunting cone snails <i>(Conus)</i> comprise eight distinct lineages evolved from ancestors that preyed on worms. In this article, we attempt to reconstruct events resulting in this shift in food resource by closely examining patterns of behavior, biochemical agents (toxins) that facilitate prey capture and the combinations of toxins present in extant species. The first sections introduce three different hunting behaviors associated with piscivory: ‘taser-and-tether', ‘net-engulfment' and ‘strike-and-stalk'. The first two fish-hunting behaviors are clearly associated with distinct groups of venom components, called cabals, which act in concert to modify the behavior of prey in a specific manner. Derived fish-hunting behavior clearly also correlates with physical features of the radular tooth, the device that injects these biochemical components. Mapping behavior, biochemical components and radular tooth features onto phylogenetic trees shows that fish-hunting behavior emerged at least twice during evolution. The system presented here may be one of the best examples where diversity in structure, physiology and molecular features were initially driven by particular pathways selected through behavior.<br>
DOI: 10.6084/m9.figshare.4122924.v1
title: Supplementary Material for: Microspectroscopic Confocal Raman and Macroscopic Biophysical Measurements in the in vivo Assessment of the Skin Barrier: Perspective for Dermatology and Cosmetic Sciences

description: <br>Skin barrier function, confined to the stratum corneum, is traditionally evaluated using established, noninvasive biophysical methods like transepidermal water loss, capacitance and conductance. However, these methods neither measure skin molecular composition nor its structure, hindering the actual causes of skin barrier change or impairment. At the same time, confocal Raman microspectroscopy (CRS) can directly measure skin molecular composition and structure and has proven itself to be a powerful technique for biomolecular analysis. The aims of this literature review were to evaluate noninvasive biophysical methods in view of CRS and to outline a direction towards more specific and informative skin measurement methods. We address this by investigating, for the first time, the relation between in vivo assessment of the skin barrier using indirect biophysical methods and the actual skin composition and structure as given by CRS, and emphasize the high potential of CRS for dermatology and cosmetic sciences. CRS acceptance in these fields will require close collaboration between dermatologists, skin scientists and spectroscopy experts towards simplifying the technology and creating robust, rapid, easy-to-use and less expensive CRS applications.
DOI: 10.7910/dvn/v1rjpf/d8hyni
title: cbb20171101_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.4122456
title: Are developments in mental scanning and mental rotation related?

description: Developmental trends of mental rotation and mental scanning<br>
DOI: 10.7910/dvn/v1rjpf/7jef3f
title: cbb20170418_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.4120224
title: Supplementary Material for: Design and Implementation of the Retinoblastoma Collaborative Laboratory

description: <br><strong><em>Purpose:</em></strong> The purpose of this work was to describe the design and implementation of a digital pathology laboratory, the Retinoblastoma Collaborative Laboratory (RbCoLab) in Kenya. <b><i>Method:</i></b> The RbCoLab is a central lab in Nairobi that receives retinoblastoma specimens from all over Kenya. Specimens were processed using evidence-based standard operating procedures. Images were produced by a digital scanner, and pathology reports were disseminated online. <b><i>Results:</i></b> The lab implemented standard operating procedures aimed at improving the accuracy, completeness, and timeliness of pathology reports, enhancing the care of Kenyan retinoblastoma patients. Integration of digital technology to support pathology services supported knowledge transfer and skills transfer. A bidirectional educational network of local pathologists and other clinicians in the circle of care of the patients emerged and served to emphasize the clinical importance of cancer pathology at multiple levels of care. A ‘Robin Hood' business model of health care service delivery was developed to support sustainability and scale-up of cancer pathology services. <b><i>Discussion:</i></b> The application of evidence-based protocols, comprehensive training, and collaboration were essential to bring improvements to the care of retinoblastoma patients in Kenya. When embraced as an integrated component of retinoblastoma care, digital pathology offers the opportunity for frequent connection and consultation for development of expertise over time.
DOI: 10.6084/m9.figshare.4122456.v1
title: Are developments in mental scanning and mental rotation related?

description: Developmental trends of mental rotation and mental scanning<br>
DOI: 10.7910/dvn/v1rjpf/gztaug
title: cbb20170722_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.4120224.v1
title: Supplementary Material for: Design and Implementation of the Retinoblastoma Collaborative Laboratory

description: <br><strong><em>Purpose:</em></strong> The purpose of this work was to describe the design and implementation of a digital pathology laboratory, the Retinoblastoma Collaborative Laboratory (RbCoLab) in Kenya. <b><i>Method:</i></b> The RbCoLab is a central lab in Nairobi that receives retinoblastoma specimens from all over Kenya. Specimens were processed using evidence-based standard operating procedures. Images were produced by a digital scanner, and pathology reports were disseminated online. <b><i>Results:</i></b> The lab implemented standard operating procedures aimed at improving the accuracy, completeness, and timeliness of pathology reports, enhancing the care of Kenyan retinoblastoma patients. Integration of digital technology to support pathology services supported knowledge transfer and skills transfer. A bidirectional educational network of local pathologists and other clinicians in the circle of care of the patients emerged and served to emphasize the clinical importance of cancer pathology at multiple levels of care. A ‘Robin Hood' business model of health care service delivery was developed to support sustainability and scale-up of cancer pathology services. <b><i>Discussion:</i></b> The application of evidence-based protocols, comprehensive training, and collaboration were essential to bring improvements to the care of retinoblastoma patients in Kenya. When embraced as an integrated component of retinoblastoma care, digital pathology offers the opportunity for frequent connection and consultation for development of expertise over time.
DOI: 10.7910/dvn/v1rjpf/tgrbmj
title: cbb20171201_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/imh4jf
title: cbb20171210_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.4117392
title: hjkhkjj

description: hhkjh
DOI: 10.6084/m9.figshare.4117392.v1
title: hjkhkjj

description: hhkjh
DOI: 10.7910/dvn/v1rjpf/jw2myf
title: cbb20170530_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/65izwe
title: cbb20170403_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.4114737
title: Fig 1 D.xls

description: RT-QPCR
DOI: 10.6084/m9.figshare.4117116
title: title 23

description: desc
DOI: 10.6084/m9.figshare.4114737.v1
title: Fig 1 D.xls

description: RT-QPCR
DOI: 10.6084/m9.figshare.4117116.v1
title: title 23

description: desc
DOI: 10.6084/m9.figshare.4114077
title: SLAMF table.xlsx

description: This table contains SLAM receptor antibodies used in flow cytometric immunophenotypic analysis, their alternative antigen names, clones, fluorochromes, isotypes, manufacturer, MFI ratios, cellular functions and references.
DOI: 10.7910/dvn/v1rjpf/ojkjcu
title: cbb20170407_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.4114077.v1
title: SLAMF table.xlsx

description: This table contains SLAM receptor antibodies used in flow cytometric immunophenotypic analysis, their alternative antigen names, clones, fluorochromes, isotypes, manufacturer, MFI ratios, cellular functions and references.
DOI: 10.6084/m9.figshare.4114059
title: Demographic data.xlsx

description: Demographic data of the patients with CLL and normal subjects.
DOI: 10.7910/dvn/v1rjpf/wx2lww
title: cbb20170119_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.4114059.v1
title: Demographic data.xlsx

description: Demographic data of the patients with CLL and normal subjects.
DOI: 10.7910/dvn/v1rjpf/jupjou
title: cbb20170129_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.4114053
title: The emergence of selective attention through probabilistic associations between stimuli and actions

description: This file contains the data set (with Figs) related to the article "The emergence of selective attention through probabilistic associations between stimuli and actions" by Luca Simione and Stefano Nolfi.
DOI: 10.6084/m9.figshare.4114053.v1
title: The emergence of selective attention through probabilistic associations between stimuli and actions

description: This file contains the data set (with Figs) related to the article "The emergence of selective attention through probabilistic associations between stimuli and actions" by Luca Simione and Stefano Nolfi.
DOI: 10.7910/dvn/v1rjpf/qfkdcp
title: cbb20170621_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.4114047
title: Data Base AgP IL-1 Micro.xls

description: Database of the variables from the patients.<br>