cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.1568146
title: <i>In vivo</i> magnetic resonance imaging of iron oxide-labeled, intravenous-injected mesenchymal stem cells in kidneys of rabbits with acute ischemic kidney injury: detection and monitoring at 1.5 T

description: <i>Background</i>: Acute kidney injury (AKI) is one of the most important causes of mortality and morbidity worldwide. Mesenchymal stem cells (MSCs) can be used for stem cell-based therapy containing AKI. Magnetic resonance imaging (MRI) is an ideal mean for stem cells tracking by labeling with superparamagnetic iron oxide (SPIO). Therefore, using the iron oxide-labeled mesenchymal stem cells (MSC) to treat the AKI and evaluating migration, distribution, and homing of cells by MRI is an ideal method for cell therapy and cell tracking <i>in vivo. Methods</i>: <i>In vitro</i>, the MSCs were labeled with 25 μg/mL for 24 h, and test the labeled efficiency and cells viability. <i>In vitro</i> experiments, magnetic resonance imaging (MRI) measurement of non-labeled and SPIO-labeled MSCs (SPIO-MSCs) was performed in correlation to detectable cells concentrations and detectable time windows. <i>In vivo</i> experiments, MRI evaluation was performed before and after ischemic/reperfusion AKI (<i>N</i> = 14) and intravenous injection of 5 × 10<sup>5</sup> SPIO-MSCs (<i>N</i> = 10), PBS (<i>N = </i>6) up to 8 days using a clinical 1.5 T scanner. Signal intensity of kidneys were measured and tested for statistical significance (unpaired Student’s <i>t</i>-test, <i>p &lt; </i>0.05) in comparison histology (hematoxylin and eosin [H&E], Prussian blue). <i>Results</i>: <i>In vitro</i>, MSCs can be labeled with the SPIO without affecting the viability and labeling efficiency. SPIO-MSCs showed a reduction of signal intensity at T2WI and T2*WI, 5 × 10<sup>4 </sup>cells/mL, SPIO-MSCs were the minimum imaging cells concentration using a 1.5 T MR <i>in vitro. In vivo</i>, SPIO-MSCs administration resulted in a T2*WI signal intensity decrease in renal medulla caused by SPIO-MSCs accumulation in contrast to control groups (<i>p &lt; </i>0.05) up to day 3 after transplantation, but T2*WI low signal intensity region of the renal medulla revealed an decrease at day 5, and no significant differences between SPIO-MSCs and control animals at day 8. <i>Conclusion</i>: Our data demonstrate that <i>in vitro</i> and <i>in vivo</i>, cell-tracking and monitoring of kidney distribution of intravenous injected SPIO-MSCs after AKI is feasible in MRI at 1.5 T.
DOI: 10.6084/m9.figshare.1568146.v1
title: <i>In vivo</i> magnetic resonance imaging of iron oxide-labeled, intravenous-injected mesenchymal stem cells in kidneys of rabbits with acute ischemic kidney injury: detection and monitoring at 1.5 T

description: <i>Background</i>: Acute kidney injury (AKI) is one of the most important causes of mortality and morbidity worldwide. Mesenchymal stem cells (MSCs) can be used for stem cell-based therapy containing AKI. Magnetic resonance imaging (MRI) is an ideal mean for stem cells tracking by labeling with superparamagnetic iron oxide (SPIO). Therefore, using the iron oxide-labeled mesenchymal stem cells (MSC) to treat the AKI and evaluating migration, distribution, and homing of cells by MRI is an ideal method for cell therapy and cell tracking <i>in vivo. Methods</i>: <i>In vitro</i>, the MSCs were labeled with 25 μg/mL for 24 h, and test the labeled efficiency and cells viability. <i>In vitro</i> experiments, magnetic resonance imaging (MRI) measurement of non-labeled and SPIO-labeled MSCs (SPIO-MSCs) was performed in correlation to detectable cells concentrations and detectable time windows. <i>In vivo</i> experiments, MRI evaluation was performed before and after ischemic/reperfusion AKI (<i>N</i> = 14) and intravenous injection of 5 × 10<sup>5</sup> SPIO-MSCs (<i>N</i> = 10), PBS (<i>N = </i>6) up to 8 days using a clinical 1.5 T scanner. Signal intensity of kidneys were measured and tested for statistical significance (unpaired Student’s <i>t</i>-test, <i>p &lt; </i>0.05) in comparison histology (hematoxylin and eosin [H&E], Prussian blue). <i>Results</i>: <i>In vitro</i>, MSCs can be labeled with the SPIO without affecting the viability and labeling efficiency. SPIO-MSCs showed a reduction of signal intensity at T2WI and T2*WI, 5 × 10<sup>4 </sup>cells/mL, SPIO-MSCs were the minimum imaging cells concentration using a 1.5 T MR <i>in vitro. In vivo</i>, SPIO-MSCs administration resulted in a T2*WI signal intensity decrease in renal medulla caused by SPIO-MSCs accumulation in contrast to control groups (<i>p &lt; </i>0.05) up to day 3 after transplantation, but T2*WI low signal intensity region of the renal medulla revealed an decrease at day 5, and no significant differences between SPIO-MSCs and control animals at day 8. <i>Conclusion</i>: Our data demonstrate that <i>in vitro</i> and <i>in vivo</i>, cell-tracking and monitoring of kidney distribution of intravenous injected SPIO-MSCs after AKI is feasible in MRI at 1.5 T.
DOI: 10.6084/m9.figshare.1568146.v3
title: <i>In vivo</i> magnetic resonance imaging of iron oxide-labeled, intravenous-injected mesenchymal stem cells in kidneys of rabbits with acute ischemic kidney injury: detection and monitoring at 1.5 T

description: <i>Background</i>: Acute kidney injury (AKI) is one of the most important causes of mortality and morbidity worldwide. Mesenchymal stem cells (MSCs) can be used for stem cell-based therapy containing AKI. Magnetic resonance imaging (MRI) is an ideal mean for stem cells tracking by labeling with superparamagnetic iron oxide (SPIO). Therefore, using the iron oxide-labeled mesenchymal stem cells (MSC) to treat the AKI and evaluating migration, distribution, and homing of cells by MRI is an ideal method for cell therapy and cell tracking <i>in vivo. Methods</i>: <i>In vitro</i>, the MSCs were labeled with 25 μg/mL for 24 h, and test the labeled efficiency and cells viability. <i>In vitro</i> experiments, magnetic resonance imaging (MRI) measurement of non-labeled and SPIO-labeled MSCs (SPIO-MSCs) was performed in correlation to detectable cells concentrations and detectable time windows. <i>In vivo</i> experiments, MRI evaluation was performed before and after ischemic/reperfusion AKI (<i>N</i> = 14) and intravenous injection of 5 × 10<sup>5</sup> SPIO-MSCs (<i>N</i> = 10), PBS (<i>N = </i>6) up to 8 days using a clinical 1.5 T scanner. Signal intensity of kidneys were measured and tested for statistical significance (unpaired Student’s <i>t</i>-test, <i>p &lt; </i>0.05) in comparison histology (hematoxylin and eosin [H&E], Prussian blue). <i>Results</i>: <i>In vitro</i>, MSCs can be labeled with the SPIO without affecting the viability and labeling efficiency. SPIO-MSCs showed a reduction of signal intensity at T2WI and T2*WI, 5 × 10<sup>4 </sup>cells/mL, SPIO-MSCs were the minimum imaging cells concentration using a 1.5 T MR <i>in vitro. In vivo</i>, SPIO-MSCs administration resulted in a T2*WI signal intensity decrease in renal medulla caused by SPIO-MSCs accumulation in contrast to control groups (<i>p &lt; </i>0.05) up to day 3 after transplantation, but T2*WI low signal intensity region of the renal medulla revealed an decrease at day 5, and no significant differences between SPIO-MSCs and control animals at day 8. <i>Conclusion</i>: Our data demonstrate that <i>in vitro</i> and <i>in vivo</i>, cell-tracking and monitoring of kidney distribution of intravenous injected SPIO-MSCs after AKI is feasible in MRI at 1.5 T.
DOI: 10.6084/m9.figshare.1568146.v2
title: <i>In vivo</i> magnetic resonance imaging of iron oxide-labeled, intravenous-injected mesenchymal stem cells in kidneys of rabbits with acute ischemic kidney injury: detection and monitoring at 1.5 T

description: <i>Background</i>: Acute kidney injury (AKI) is one of the most important causes of mortality and morbidity worldwide. Mesenchymal stem cells (MSCs) can be used for stem cell-based therapy containing AKI. Magnetic resonance imaging (MRI) is an ideal mean for stem cells tracking by labeling with superparamagnetic iron oxide (SPIO). Therefore, using the iron oxide-labeled mesenchymal stem cells (MSC) to treat the AKI and evaluating migration, distribution, and homing of cells by MRI is an ideal method for cell therapy and cell tracking <i>in vivo. Methods</i>: <i>In vitro</i>, the MSCs were labeled with 25 μg/mL for 24 h, and test the labeled efficiency and cells viability. <i>In vitro</i> experiments, magnetic resonance imaging (MRI) measurement of non-labeled and SPIO-labeled MSCs (SPIO-MSCs) was performed in correlation to detectable cells concentrations and detectable time windows. <i>In vivo</i> experiments, MRI evaluation was performed before and after ischemic/reperfusion AKI (<i>N</i> = 14) and intravenous injection of 5 × 10<sup>5</sup> SPIO-MSCs (<i>N</i> = 10), PBS (<i>N = </i>6) up to 8 days using a clinical 1.5 T scanner. Signal intensity of kidneys were measured and tested for statistical significance (unpaired Student’s <i>t</i>-test, <i>p &lt; </i>0.05) in comparison histology (hematoxylin and eosin [H&E], Prussian blue). <i>Results</i>: <i>In vitro</i>, MSCs can be labeled with the SPIO without affecting the viability and labeling efficiency. SPIO-MSCs showed a reduction of signal intensity at T2WI and T2*WI, 5 × 10<sup>4 </sup>cells/mL, SPIO-MSCs were the minimum imaging cells concentration using a 1.5 T MR <i>in vitro. In vivo</i>, SPIO-MSCs administration resulted in a T2*WI signal intensity decrease in renal medulla caused by SPIO-MSCs accumulation in contrast to control groups (<i>p &lt; </i>0.05) up to day 3 after transplantation, but T2*WI low signal intensity region of the renal medulla revealed an decrease at day 5, and no significant differences between SPIO-MSCs and control animals at day 8. <i>Conclusion</i>: Our data demonstrate that <i>in vitro</i> and <i>in vivo</i>, cell-tracking and monitoring of kidney distribution of intravenous injected SPIO-MSCs after AKI is feasible in MRI at 1.5 T.
DOI: 10.6084/m9.figshare.1568179
title: Membrane fouling control in the integrated process of magnetic anion exchange and ultrafiltration

description: Magnetic anion exchange (MIEX) has been increasingly concerned owing to its excellent performance for the removal of dissolved organic carbon in the treatment of drinking water. In this study, the ability of ultrafiltration (UF) membrane fouling control was analyzed by different combination processes of MIEX-UF. A single cycle and multi-cycle operations were conducted, and the separated and integrated processes of MIEX-UF were compared. Membrane filtration resistance, removal of organics, and morphologies of the membrane surface were analyzed. The results of the short-term operation did not show any obvious improvement in the membrane fouling control in the separated process (compared to UF alone); however, a marked improvement was obtained in the integrated process. The membrane filtration resistance analysis showed that the cake resistance (<i>R</i><sub>c</sub>) and pore blocking resistance (<i>R</i><sub>p</sub>) in the integrated process were only 52 and 24% of the values in the separated process. The multi-cycle operation demonstrated that the cumulative rate of hydraulically irreversible fouling was 0.0021 in the integrated process and was much lower than that in the separated process (0.0182). The mechanistic analysis shows that in the integrated process, a dynamic layer was formed on the membrane surface by the deposited MIEX beads, which markedly decreased the accumulation of the membrane foulants on the membrane surface and in the membrane pores.
DOI: 10.6084/m9.figshare.1568179.v1
title: Membrane fouling control in the integrated process of magnetic anion exchange and ultrafiltration

description: Magnetic anion exchange (MIEX) has been increasingly concerned owing to its excellent performance for the removal of dissolved organic carbon in the treatment of drinking water. In this study, the ability of ultrafiltration (UF) membrane fouling control was analyzed by different combination processes of MIEX-UF. A single cycle and multi-cycle operations were conducted, and the separated and integrated processes of MIEX-UF were compared. Membrane filtration resistance, removal of organics, and morphologies of the membrane surface were analyzed. The results of the short-term operation did not show any obvious improvement in the membrane fouling control in the separated process (compared to UF alone); however, a marked improvement was obtained in the integrated process. The membrane filtration resistance analysis showed that the cake resistance (<i>R</i><sub>c</sub>) and pore blocking resistance (<i>R</i><sub>p</sub>) in the integrated process were only 52 and 24% of the values in the separated process. The multi-cycle operation demonstrated that the cumulative rate of hydraulically irreversible fouling was 0.0021 in the integrated process and was much lower than that in the separated process (0.0182). The mechanistic analysis shows that in the integrated process, a dynamic layer was formed on the membrane surface by the deposited MIEX beads, which markedly decreased the accumulation of the membrane foulants on the membrane surface and in the membrane pores.
DOI: 10.6084/m9.figshare.1568252
title: High-dose versus conventional-dose irradiation in cisplatin-based definitive concurrent chemoradiotherapy for esophageal cancer: a systematic review and pooled analysis

description: We investigate whether high-dose (HD, ≥60 Gy) radiotherapy in definitive concurrent chemoradiotherapy (CCRT) based on cisplatin could yield benefits compared to conventional-dose (CD) CCRT. PubMed, Embase and Google Scholar were searched and data were pooled and analyzed for response rate, survival, failure patterns and toxicity. Results showed advantages in response rate, 5-year overall survival rate, local regional recurrence and distant failure rate compared to the CD arm with no difference in Grade ≥3 acute and late esophagitis, other toxicities were rare with moderate tolerance, subgroup analysis of squamous cell carcinoma also showed advantages for HD arm. We concluded that ≥60 Gy CCRT improved clinical outcomes compared to the CD arm, especially for esophageal squamous cell carcinoma. Our findings may provide a basis for future trials.
DOI: 10.6084/m9.figshare.1568252.v1
title: High-dose versus conventional-dose irradiation in cisplatin-based definitive concurrent chemoradiotherapy for esophageal cancer: a systematic review and pooled analysis

description: We investigate whether high-dose (HD, ≥60 Gy) radiotherapy in definitive concurrent chemoradiotherapy (CCRT) based on cisplatin could yield benefits compared to conventional-dose (CD) CCRT. PubMed, Embase and Google Scholar were searched and data were pooled and analyzed for response rate, survival, failure patterns and toxicity. Results showed advantages in response rate, 5-year overall survival rate, local regional recurrence and distant failure rate compared to the CD arm with no difference in Grade ≥3 acute and late esophagitis, other toxicities were rare with moderate tolerance, subgroup analysis of squamous cell carcinoma also showed advantages for HD arm. We concluded that ≥60 Gy CCRT improved clinical outcomes compared to the CD arm, especially for esophageal squamous cell carcinoma. Our findings may provide a basis for future trials.
DOI: 10.6084/m9.figshare.1568261
title: A new small enantiornithine bird from the Jehol Biota, with implications for early evolution of avian skull morphology

description: Enantiornithes is the most diverse Mesozoic avian clade. Approximately half of the known global diversity of Enantiornithes is from the Early Cretaceous Jehol Biota of China. The Jehol enantiornithines are usually articulated and complete, but the bones are overlain by each other and preserved in two dimensions, severely limiting the number of cranial characters that can be recognized. Here we describe a new enantiornithine bird, <i>Pterygornis dapingfangensis</i> gen. et sp. nov., from the Jehol Biota. The new taxon has a unique sternal morphology with an external rostral spine and a pair of craniolateral processes. Phylogenetic analysis resolves the new taxon in a derived position within Enantiornithes. The specimen is disarticulated with several exceptionally well-preserved cranial bones, including the jugal and quadratojugal, morphologies of which remain poorly understood for enantiornithines. Our results indicate that the quadratojugal is an inverted L-shaped element, morphologically similar to that of more basal birds <i>Archaeopteryx bavarica, Jeholornis prima, Confuciusornis sanctus</i> and <i>Sapeornis chaoyangensis</i>. Our findings also illustrate that the quadratojugal underwent large modifications with the reduction of the caudoventral and squamosal processes sequentially during early avian evolution, contributing to the refinement of the cranial kinesis in early birds. http://zoobank.org/urn:lsid:zoobank.org:pub:384D11F5-1CD3-4447-B01E-58D320B42D49
DOI: 10.6084/m9.figshare.1568261.v1
title: A new small enantiornithine bird from the Jehol Biota, with implications for early evolution of avian skull morphology

description: Enantiornithes is the most diverse Mesozoic avian clade. Approximately half of the known global diversity of Enantiornithes is from the Early Cretaceous Jehol Biota of China. The Jehol enantiornithines are usually articulated and complete, but the bones are overlain by each other and preserved in two dimensions, severely limiting the number of cranial characters that can be recognized. Here we describe a new enantiornithine bird, <i>Pterygornis dapingfangensis</i> gen. et sp. nov., from the Jehol Biota. The new taxon has a unique sternal morphology with an external rostral spine and a pair of craniolateral processes. Phylogenetic analysis resolves the new taxon in a derived position within Enantiornithes. The specimen is disarticulated with several exceptionally well-preserved cranial bones, including the jugal and quadratojugal, morphologies of which remain poorly understood for enantiornithines. Our results indicate that the quadratojugal is an inverted L-shaped element, morphologically similar to that of more basal birds <i>Archaeopteryx bavarica</i>, <i>Jeholornis prima</i>, <i>Confuciusornis sanctus</i> and <i>Sapeornis chaoyangensis</i>. Our findings also illustrate that the quadratojugal underwent large modifications with the reduction of the caudoventral and squamosal processes sequentially during early avian evolution, contributing to the refinement of the cranial kinesis in early birds.http://zoobank.org/urn:lsid:zoobank.org:pub:384D11F5-1CD3-4447-B01E-58D320B42D49
DOI: 10.6084/m9.figshare.1568261.v2
title: A new small enantiornithine bird from the Jehol Biota, with implications for early evolution of avian skull morphology

description: Enantiornithes is the most diverse Mesozoic avian clade. Approximately half of the known global diversity of Enantiornithes is from the Early Cretaceous Jehol Biota of China. The Jehol enantiornithines are usually articulated and complete, but the bones are overlain by each other and preserved in two dimensions, severely limiting the number of cranial characters that can be recognized. Here we describe a new enantiornithine bird, <i>Pterygornis dapingfangensis</i> gen. et sp. nov., from the Jehol Biota. The new taxon has a unique sternal morphology with an external rostral spine and a pair of craniolateral processes. Phylogenetic analysis resolves the new taxon in a derived position within Enantiornithes. The specimen is disarticulated with several exceptionally well-preserved cranial bones, including the jugal and quadratojugal, morphologies of which remain poorly understood for enantiornithines. Our results indicate that the quadratojugal is an inverted L-shaped element, morphologically similar to that of more basal birds <i>Archaeopteryx bavarica, Jeholornis prima, Confuciusornis sanctus</i> and <i>Sapeornis chaoyangensis</i>. Our findings also illustrate that the quadratojugal underwent large modifications with the reduction of the caudoventral and squamosal processes sequentially during early avian evolution, contributing to the refinement of the cranial kinesis in early birds. http://zoobank.org/urn:lsid:zoobank.org:pub:384D11F5-1CD3-4447-B01E-58D320B42D49
DOI: 10.6084/m9.figshare.1568367
title: Late Palaeozoic <sup>40</sup>Ar/<sup>39</sup>Ar ages of the HP-LT metamorphic rocks from the Kekesu Valley, Chinese southwestern Tianshan: new constraints on exhumation tectonics

description: Although numerous ages have been obtained for the Chinese southwestern Tianshan high pressure/ultrahigh pressure-low temperature (HP/UHP-LT) metamorphic belt in the past two decades, its exhumation history is still controversial. The poor age constraint was related to the appealing low metamorphic temperatures and excess Ar commonly present under HP/UHP conditions. This study aims to provide new age constraints on the orogen’s exhumation by obtaining <sup>40</sup>Ar/<sup>39</sup>Ar mica ages using the conventional step-heating technique, with emphasis on the avoidance of excess Ar contamination. From a cross section along the Kekesu Valley, four samples, three from the HP-LT metamorphic belt (TK050, TK051, and TK081) and one from the southern margin of the low pressure metamorphic belt (TK097), were selected for <sup>40</sup>Ar/<sup>39</sup>Ar dating. Phengites from garnet glaucophane schist TK050 and the surrounding rock garnet phengite schist TK051 yield comparable plateau ages of 321.4 ± 1.6 and 318.6 ± 1.6 Ma, respectively, while epidote mica schist TK081 gives a younger plateau age of 293.3 ± 1.5 Ma. Considering the chemical compositions of phengites, mineral assemblages, and microstructures in the thin slices, we suppose that the former represents the time the HP rocks retrograded from the peak stage (eclogite facies) to the (epidote)-blueschist facies, whereas the latter reflects greenschist facies overprinting. Biotite and muscovite from two-mica quartzite TK097 give similar plateau ages of 253.0 ± 1.3 and 247.1 ± 1.2 Ma, interpreted to date movement on the post collisional transcrustal South Nalati ductile shear zone. By combining our new ages with published data, a two-stage exhumation model is suggested for the Chinese southwestern Tianshan HP/UHP-LT metamorphic belt: initial fast exhumation to a depth of about 30–35 km by ~320 Ma was followed by relatively slow (~1 mm year<sup>–1</sup>) uplift to ~10 km by ~293 Ma.