cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.15468/dl.ts9qyp
title: Occurrence Download

description: A dataset containing 4 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Cypricercus cuneatus, , , Cypridopsis vidua, , Eundacypris, , Globocypris, , Gomphocythere obtusata, , Hemicypris, Heterocypris aurea, Cypricercus xhosa, , , Heterocypris incongruens, , , , , Humphcypris, , Hypselecypris, Ilyodromus viridulus, Ilyodromus, , , , Kapcypridopsis barnardi, Kapcypridopsis, Liocypris grandis, Liocypris, , , Megalocypris princeps, , Mesocypris, , , , , , , , , , Potamocypris humilis, Potamocypris, , , , , , , , , Ramotha, , , Cypridopsis aculeata, Sarscypridopsis, , , , , Sarscypridopsis glabrata, Sarscypridopsis gregaria, , , , , , )",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "BasisOfRecord is one of (Specimen, Living Specimen, Observation, Human Observation, Machine Observation, Material sample, Literature Occurrence, Material citation, Occurrence evidence)",
 "Geometry POLYGON ((32.064 -28.9416,32.4847 -28.5786,30.5701 -28.5786,30.5701 -30.7329,30.6252 -30.6659,31.4179 -29.4257,31.8178 -29.0299,32.064 -28.9416))"
 ]
}

 The dataset includes 4 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0066662-250717081556266/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.3535/jzc-rgx-4me
title: Aethionema syriacum (Boiss.) Bornm.

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.15468/dl.v95afe
title: Occurrence Download

description: A dataset containing 2653572 species occurrences available in GBIF matching the query:
{
 "DatasetKey" : [
 "is Swiss National Butterflies and Forester Moths Databank"
 ]
}

 The dataset includes 2653572 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0066644-250717081556266/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.3535/76l-yyc-1jt
title: Mackaya atroviridis (Wall. ex T. Anderson) Das

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/l0m-zha-24y
title: Aethionema speciosum Boiss. & A. Huet

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/erc-r5l-7ct
title: Senega tuberculata (Chodat) J. F. B. Pastore

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/f31-vre-g4m
title: Senega longicaulis (Kunth) J. F. B. Pastore

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/9fq-s0h-0kl
title: Dyschoriste maranhonis (Nees) Kuntze

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/b3m-5lz-z0e
title: Heliotropium sogdianum Bunge

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/7dw-2t3-6k4
title: Noccaea trinervia (DC.) Steud.

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/dvx-pb6-8cj
title: Calytrix sapphirina Lindl.

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/vyz-fkj-yq4
title: Croton sclerocalyx (Didr.) Müll.Arg.

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/ccb-17e-21x
title: Croton timandroides (Didr.) Müll.Arg.

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/wlf-14b-5tb
title: Taxandria parviceps (Schauer) J. R. Wheeler & N. G. Marchant

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/ajt-k0d-fpc
title: Croton serratifolius Baill.

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/j68-0kc-ae6
title: Croton salutaris Casar.

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/8hp-040-l13
title: Hysterobaeckea behrii (Schltdl.) Rye

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/the-jxa-x2w
title: Calytrix leschenaultii (Schauer) Benth.

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/tly-b91-vzh
title: Melaleuca macrostemon (Lindl.) Craven & R. D. Edwards

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/1m2-8kk-p5b
title: Dianthus libanotis Labill.

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/bva-7kk-try
title: Amomyrtus luma (Molina) D. Legrand & Kausel

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/7gb-39s-t2s
title: Baeckea gunniana Schauer ex Walp.

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/gx9-764-5dh
title: Cleome microcarpa Ule

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/dh2-aqj-g3h
title: Rinzia schollerifolia (Lehm.) Trudgen

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/mbs-nnf-b0j
title: Calytrix fraseri A. Cunn.

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/2zx-d4a-yq8
title: Aethionema saxatile subsp. saxatile

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/0md-3la-1qd
title: Tarenaya atropurpurea (Schott) Soares Neto & Roalson

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/pn5-nss-sfp
title: Tarenaya spinosa (Jacq.) Raf.

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/9rx-7a8-ddb
title: Myriopus villosus (Salzm. ex DC.) J. I. M. Melo

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/rzm-j9w-shp
title: Melaleuca jonesii Craven & R. D. Edwards

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/n0q-tp8-cgw
title: Myrcia neolucida A. R. Lourenço & E. Lucas

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/th7-9a8-tmy
title: Myriopus villosus (Salzm. ex DC.) J. I. M. Melo

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.15468/dl.avmhbu
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Cypricercus cuneatus, , , Cypridopsis vidua, , Eundacypris, , Globocypris, , Gomphocythere obtusata, , Hemicypris, Heterocypris aurea, Cypricercus xhosa, , , Heterocypris incongruens, , , , , Humphcypris, , Hypselecypris, Ilyodromus viridulus, Ilyodromus, , , , Kapcypridopsis barnardi, Kapcypridopsis, Liocypris grandis, Liocypris, , , Megalocypris princeps, , Mesocypris, , , , , , , , , , Potamocypris humilis, Potamocypris, , , , , , , , , Ramotha, , , Cypridopsis aculeata, Sarscypridopsis, , , , , Sarscypridopsis glabrata, Sarscypridopsis gregaria, , , , , , )",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "BasisOfRecord is one of (Specimen, Living Specimen, Observation, Human Observation, Machine Observation, Material sample, Literature Occurrence, Material citation, Occurrence evidence)",
 "Geometry POLYGON ((31.8862 -21.3285,30.5701 -20.3186,30.5701 -24.0715,35.5909 -24.0715,35.6007 -24.0157,35.6007 -23.8125,35.4969 -23.7035,35.6007 -23.165,35.6007 -22.9702,35.227 -22.2482,34.6862 -21.6944,34.013 -21.3095,33.5 -21.1593,32.9675 -21.1092,32.4352 -21.1612,31.8862 -21.3285))"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0066663-250717081556266/datasets/export for details.
DOI: 10.3535/zxf-rw7-wjr
title: Aethionema saxatile subsp. saxatile

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/edp-j1m-snf
title: Aethionema saxatile subsp. saxatile

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/wlk-smb-vtx
title: Galium serpylloides Royle ex Hook.f.

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/9nt-07y-knx
title: Salix L.

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/h5t-lay-gn6
title: Myriopus breviflorus (DC.) Luebert

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/dtz-max-a7g
title: Campomanesia adamantium (Cambess.) O. Berg

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/2cd-xma-4ly
title: Salix starkeana Willd.

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/wlg-stx-ksg
title: Myrcia pendens A. R. Lourenço & Sánchez-Cháv.

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/aek-lgl-rj4
title: Salix starkeana Willd.

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/v7w-2eb-epn
title: Neomitranthes obscura (DC.) N. Silveira

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/vej-fj1-wyb
title: Calytrix tetragona Labill.

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/50a-x7v-mnj
title: Calytrix tetragona Labill.

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/e26-pg7-qp3
title: Myrcia grammica (Spreng.) A. R. Lourenço & E. Lucas

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/fml-1m7-fbp
title: Carex panicea L.

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/y1m-prl-731
title: Calytrix angulata Lindl.

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/dxy-7lj-rlh
title: Myrcia neoclusiifolia A. R. Lourenço & E. Lucas

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/p5q-v7a-d0e
title: Myrcia grammica (Spreng.) A. R. Lourenço & E. Lucas

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/73n-vkd-wdh
title: Calytrix brevifolia (Meisn.) Benth.

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/csj-m64-tzz
title: Myrcia neolucida A. R. Lourenço & E. Lucas

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/lpg-0mh-xtq
title: Myriopus villosus (Salzm. ex DC.) J. I. M. Melo

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/mjx-ng2-qa6
title: Carex hirta L.

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/fxq-ydy-3m7
title: Tournefortia hirsutissima L.

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/b1k-1bw-4yh
title: Tournefortia L.

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/ktp-vw1-h9m
title: Melaleuca macrostemon (Lindl.) Craven & R. D. Edwards

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/cbt-fcy-mja
title: Canarium asperum Benth.

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/hxc-fn4-8cw
title: Onosma pachypoda Boiss.

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/8qb-pga-e02
title: Streblosa tortilis (Blume) Korth.

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/hbh-vrg-kxd
title: Nonea pulmonarioides Boiss. & Balansa

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/3hw-rg7-yqg
title: Nonea persica Boiss.

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/lbx-7kx-cts
title: Psychotria calocarpa Kurz

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/f63-v3h-b8g
title: Psychotria wawrae Sohmer

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/aef-76r-hj2
title: Aethionema saxatile subsp. saxatile

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/t88-9vb-x05
title: Aethionema saxatile subsp. saxatile

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/dl2-tvd-ff2
title: Astartoseris triquetra (Labill.) N. Kilian, Hand, Hadjik., Christodoulou & Bou Dagh.

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/xr2-4yc-8g7
title: Trichodesma khasianum C. B. Clarke

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.5281/zenodo.16565159
title: The Impact of Gamification on Student Learning and Motivation in Introductory Programming Courses
DOI: 10.5281/zenodo.16565160
title: The Impact of Gamification on Student Learning and Motivation in Introductory Programming Courses
DOI: 10.3535/5yr-6lm-3as
title: Canarium littorale Blume

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/acx-rl5-ksd
title: Psychotria pickeringii A.Gray

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/4va-ebq-gnj
title: Myosotis spathulata G. Forst.

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/vrd-q73-3b1
title: Campomanesia dichotoma (O. Berg) Mattos

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/n83-jcb-0aa
title: Psychotria thomsonii Hook.f.

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/p8x-45m-zta
title: Dalechampia pernambucensis Baill.

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/ldw-428-l0y
title: Campomanesia eugenioides (Cambess.) D. Legrand ex Landrum

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/614-rvc-24s
title: Dalechampia pentaphylla Lam.

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/7bs-60d-7vl
title: Dalechampia pentaphylla Lam.

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/w3j-heh-v4d
title: Dalechampia tiliifolia Lam.

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/yys-h3s-e73
title: Aethionema saxatile subsp. saxatile

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/bxe-m1p-kqq
title: Ilex myricoides Kunth

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/tbq-wgh-r2h
title: Dodonaea larraeoides Turcz.

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/660-nz7-yaq
title: Aethionema saxatile subsp. saxatile

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/2k3-frm-9g7
title: Dalechampia scandens var. heterodonta Müll.Arg.

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/jds-xge-q7t
title: Aethionema saxatile subsp. saxatile

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/5vj-42g-nq4
title: Palicourea fastigiata Kunth

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/ywp-89p-2q7
title: Aethionema saxatile subsp. saxatile

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.15468/dl.yhzd4v
title: Occurrence Download

description: A dataset containing 42 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Solemyida",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "Year is greater than or equal to 2023",
 "Year is less than or equal to 2024"
 ]
}

 The dataset includes 42 records from 4 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0066664-250717081556266/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.3535/k0f-pse-mt8
title: Acianthera strupifolia (Lindl.) Pridgeon & M.W.Chase

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.15468/dl.2ms36j
title: Occurrence Download

description: A dataset containing 934400 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Pyrocephalus rubinus)",
 "HasCoordinate is true",
 "OccurrenceStatus is Present",
 "License is one of (CC-BY 4.0, CC0 1.0)"
 ]
}

 The dataset includes 934400 records from 171 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0066631-250717081556266/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.3535/0xj-ej7-d31
title: Habenaria goyazensis Cogn.

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/x4w-2wg-7kr
title: Melaleuca phoenicea (Lindl.) Craven

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.6084/m9.figshare.28485371
title: Source Datas.xlsx

description: BackgroundSurface engineering emerges as a promising strategy to enhance the performance of nanomedicines. In particular, the level of PEGylation in prodrug nanoassemblies plays a crucial role in determining their stability, drug release kinetics, cytotoxicity, cellular uptake, <i>in vivo</i> pharmacokinetics, biodistribution and antitumor efficacy.MethodsWe systematically evaluated the effect of surface engineering ratios (0% NPs, 5%, 20%, 40%, 60% 80%, 100%, 150%, 200%, W<sub>DSPE-mPEG2k</sub>/W<sub>prodrug</sub>) on the SN38 prodrug nanoassemblies. Drug release kinetics were measured using high-performance liquid chromatography (HPLC), while cytotoxicity was assessed via the MTT assay. Cellular uptake was accurately quantified using an HPLC-MS-8060 system. In vivo pharmacokinetics were evaluated in Sprague-Dawley (SD) rats, and the biodistribution and antitumor efficacy were assessed using a CT26 colon tumor model established in Balb/c mice. Additionally, we examined intestinal toxicity to evaluate the safety profile.ResultsAlthough all of these ratios could form nanoparticles, 80% NPs showed excellent stability, cytotoxicity, and cellular uptake. However, 80% NPs were quickly cleared by the mononuclear phagocyte system (MPS) <i>in vivo</i>, causing SN38 leakage and intestinal toxicity. In comparison, 150% NPs maintained structural integrity in systemic circulation due to their sufficient PEGylation level, which allowed for significant accumulation at the tumor site through the enhanced permeability and retention (EPR) effect.Conclusions150% NPs exhibited the best antitumor effect and the lowest intestinal toxicity. Our findings underscore the critical impact of PEGylation levels to enhance the performance and safety of SN38 prodrug nanoassemblies.
DOI: 10.3535/ls3-c74-ph8
title: Aspidosperma cuspa (Kunth) S. F. Blake ex Pittier

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/myc-b8v-95b
title: Cheiloclinium cognatum (Miers) A. C. Sm.

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.6084/m9.figshare.28485371.v2
title: Source Datas.xlsx

description: BackgroundSurface engineering emerges as a promising strategy to enhance the performance of nanomedicines. In particular, the level of PEGylation in prodrug nanoassemblies plays a crucial role in determining their stability, drug release kinetics, cytotoxicity, cellular uptake, <i>in vivo</i> pharmacokinetics, biodistribution and antitumor efficacy.MethodsWe systematically evaluated the effect of surface engineering ratios (0% NPs, 5%, 20%, 40%, 60% 80%, 100%, 150%, 200%, W<sub>DSPE-mPEG2k</sub>/W<sub>prodrug</sub>) on the SN38 prodrug nanoassemblies. Drug release kinetics were measured using high-performance liquid chromatography (HPLC), while cytotoxicity was assessed via the MTT assay. Cellular uptake was accurately quantified using an HPLC-MS-8060 system. In vivo pharmacokinetics were evaluated in Sprague-Dawley (SD) rats, and the biodistribution and antitumor efficacy were assessed using a CT26 colon tumor model established in Balb/c mice. Additionally, we examined intestinal toxicity to evaluate the safety profile.ResultsAlthough all of these ratios could form nanoparticles, 80% NPs showed excellent stability, cytotoxicity, and cellular uptake. However, 80% NPs were quickly cleared by the mononuclear phagocyte system (MPS) <i>in vivo</i>, causing SN38 leakage and intestinal toxicity. In comparison, 150% NPs maintained structural integrity in systemic circulation due to their sufficient PEGylation level, which allowed for significant accumulation at the tumor site through the enhanced permeability and retention (EPR) effect.Conclusions150% NPs exhibited the best antitumor effect and the lowest intestinal toxicity. Our findings underscore the critical impact of PEGylation levels to enhance the performance and safety of SN38 prodrug nanoassemblies.
DOI: 10.6084/m9.figshare.28485371.v3
title: Source Datas.xlsx

description: BackgroundSurface engineering emerges as a promising strategy to enhance the performance of nanomedicines. In particular, the level of PEGylation in prodrug nanoassemblies plays a crucial role in determining their stability, drug release kinetics, cytotoxicity, cellular uptake, <i>in vivo</i> pharmacokinetics, biodistribution and antitumor efficacy.MethodsWe systematically evaluated the effect of surface engineering ratios (0% NPs, 5%, 20%, 40%, 60% 80%, 100%, 150%, 200%, W<sub>DSPE-mPEG2k</sub>/W<sub>prodrug</sub>) on the SN38 prodrug nanoassemblies. Drug release kinetics were measured using high-performance liquid chromatography (HPLC), while cytotoxicity was assessed via the MTT assay. Cellular uptake was accurately quantified using an HPLC-MS-8060 system. In vivo pharmacokinetics were evaluated in Sprague-Dawley (SD) rats, and the biodistribution and antitumor efficacy were assessed using a CT26 colon tumor model established in Balb/c mice. Additionally, we examined intestinal toxicity to evaluate the safety profile.ResultsAlthough all of these ratios could form nanoparticles, 80% NPs showed excellent stability, cytotoxicity, and cellular uptake. However, 80% NPs were quickly cleared by the mononuclear phagocyte system (MPS) <i>in vivo</i>, causing SN38 leakage and intestinal toxicity. In comparison, 150% NPs maintained structural integrity in systemic circulation due to their sufficient PEGylation level, which allowed for significant accumulation at the tumor site through the enhanced permeability and retention (EPR) effect.Conclusions150% NPs exhibited the best antitumor effect and the lowest intestinal toxicity. Our findings underscore the critical impact of PEGylation levels to enhance the performance and safety of SN38 prodrug nanoassemblies.
DOI: 10.3535/38m-8tc-ftg
title: Psychotria hexandra H.Mann

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/6dc-za3-qxp
title: Aspidosperma macrocarpon Mart.

description: Digital Specimen for the physical specimen hosted at University of Graz.