DOI: 10.5061/dryad.h9w0vt4sk
title: Data from: Low chronotropic response in post-myocardial infarction exercise test predicts worse prognosis in patients with preserved or mildly reduced left ventricular ejection fraction

description: Background: Chronotropic incompetence is common in post-myocardial
 infarction (MI) patients and is associated with reduced exercise capacity.
 However, its prognostic significance and the determination of threshold
 values for prognosis remain unclear. Methods: We assessed 96 post-MI
 patients with LVEF ≥ 40% at 4 weeks post-event. Patients underwent
 combined exercise stress echocardiography and cardiopulmonary exercise
 testing (CPET-SE). The chronotropic response was measured as a percent of
 the maximal predicted heart rate at peak exercise (%MPHR). Eighty-six
 patients completed follow-up (median duration: 4.0 years [IQR 2, 5.6]).
 The primary endpoint was a composite of all-cause mortality or unplanned
 hospitalization for coronary syndromes or heart failure
 exacerbation.  Results: Median age was 60 years (IQR 53, 65), 67%
 of patients were male, 86% were on beta-blockers, the median LVEF was 57%
 (IQR 51, 62), and the median peak VO2 was 19 mL/kg/min (IQR 15, 22).
 Fifteen composite endpoint events occurred, including 3 deaths. A %MPHR
 threshold of 67% best predicted the primary endpoint (AUC 73%, PPV 29%,
 NPV 95%, sensitivity 87%, specificity 55%). The primary endpoint
 occurrence differed significantly between patients below and above this
 threshold (p = 0.002). In the multivariate Cox regression analysis, %MPHR
 (HR 0.95, 95% CI 0.92-0.98) and smoking history (HR 2.8, 95% CI 1.1-7.4)
 correlated with the primary endpoint.  Conclusions: A
 chronotropic response below 67% of the maximal predicted heart rate is a
 negative prognostic marker in post-MI patients with preserved or mildly
 reduced LVEF. This threshold may help risk-stratify and guide management
 in this population.
description: Information in metadata .txt file
description: GENERAL INFORMATION Metadata for the file
 “raw_dataset_low_chronotropic_response_in_post-myocardial_infarction_exercise_test.csv” Krzysztof Smarz Department of Cardiology, Centre of Postgraduate Medical Education, Grochowski Hospital, Grenadierów 51/59, 04-073 Warsaw, Poland. Maciej Tysarowski Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520-8056, USA Date of data collection: October 2015 to January 2019 Location of data collection: Warsaw, Poland METHODOLOGICAL INFORMATION Patients were followed for 4 years. If an endpoint occurred, the time of follow-up was measured to the date of the endpoint. The primary endpoint was a composite of all-cause mortality or unplanned hospitalization for coronary syndromes (acute MI/unstable angina, chronic coronary syndromes) or heart failure exacerbation. DATA-SPECIFIC INFORMATION Number of variables: 670 Number of cases/rows: 99 rows of individual patients (not including the header) Missing data codes: NA VARIABLES id: a unique identifier for each patient sex_hosp: sex of the patient at hospital admission (1 for male, 0 for female) age_mi_hosp: age at the time of myocardial infarction, years mi_date_hosp: date of myocardial infarction cpet_1_date_hosp: date of the first cardiopulmonary exercise test cpet_2_date_hosp: date of the second cardiopulmonary exercise test smoking_now_hosp: current smoking status at hospital admission (1 for yes, 0 for no) smoking_past_hosp: history of past smoking (1 for yes, 0 for no) copd_asthma_hosp: history of COPD or asthma (1 for yes, 0 for no) htn_hosp: history of hypertension (1 for yes, 0 for no) hld_hosp: history of hyperlipidemia (1 for yes, 0 for no) dm_igt_hosp: history of diabetes mellitus or impaired fasting glucose (1 for yes, 0 for no) fh_cad_hosp: family history of coronary artery disease (1 for yes, 0 for no) cad_hosp: history of coronary artery disease (1 for yes, 0 for no) angina_hosp: history of angina (1 for yes, 0 for no) ckd_hosp: history of chronic kidney disease (1 for yes, 0 for no) stroke_tia_hosp: history of stroke or transient ischemic attack (1 for yes, 0 for no) chf_hosp: history of congestive heart failure (1 for yes, 0 for no) pci_hosp: history of percutaneous coronary intervention (1 for yes, 0 for no) stress_test_positive_hosp: positive result on stress test (1 for yes, 0 for no) atherosclerosis_hosp: presence of atherosclerosis (1 for yes, 0 for no) af_past_hosp: history of atrial fibrillation (1 for yes, 0 for no) cancer_now_past_hosp: history of or current diagnosis of cancer (1 for yes, 0 for no) significant_bleeding_past_hosp: history of significant bleeding (1 for yes, 0 for no) physical_activity_before_mi_small_hosp: low physical activity before myocardial infarction (1 for yes, 0 for no) physical_activity_before_mi_moderate_hosp: moderate physical activity before myocardial infarction (1 for yes, 0 for no) physical_activity_before_mi_high_hosp: high physical activity before myocardial infarction (1 for yes, 0 for no) mi_pain_start_date_hosp: date when myocardial infarction pain started hospital_admission_date_hosp: date of hospital admission cath_no_sign_changes_hosp: no significant changes on catheterization (1 for yes, 0 for no) cath_sign_changes_but_medical_therapy_hosp: significant changes on catheterization but managed with medical therapy (1 for yes, 0 for no) cath_mi_date_hosp: date of catheterization lm_more_equal50_hosp: left main coronary artery stenosis ≥ 50% (1 for yes, 0 for no) lm_less_50_hosp: left main coronary artery stenosis &lt; 50% (1 for yes, 0 for no) number_arteries_more_90_hosp: number of arteries with ≥ 90% stenosis number_arteries_71_89_hosp: number of arteries with 71-89% stenosis number_arteries_50_70_hosp: number of arteries with 50-70% stenosis number_arteries_less_50_hosp: number of arteries with &lt; 50% stenosis number_arteries_blocked_hosp: total number of blocked arteries pci_start_date_hosp: date when percutaneous coronary intervention was performed culprit_lesion_segmeng_hosp: segment of the coronary artery identified as the culprit lesion pci_segment_1_hosp: first segment treated with PCI pci_segment_2_hosp: second segment treated with PCI pci_segment_3_hosp: third segment treated with PCI pci_segment_6_hosp: sixth segment treated with PCI pci_segment_7_hosp: seventh segment treated with PCI pci_segment_8_hosp: eighth segment treated with PCI pci_segment_11_hosp: eleventh segment treated with PCI pci_segment_12_hosp: twelfth segment treated with PCI pci_segment_13_hosp: thirteenth segment treated with PCI other_narrowings_more_50_hosp: presence of other arterial narrowings &gt; 50% (1 for yes, 0 for no) timi_number_culprit_lesion_before_pci_hosp: TIMI flow grade of the culprit lesion before PCI timi_0_culprit_lesion_before_pci_hosp: TIMI 0 flow grade before PCI (1 for yes, 0 for no) timi_1_culprit_lesion_before_pci_hosp: TIMI 1 flow grade before PCI (1 for yes, 0 for no) timi_2_culprit_lesion_before_pci_hosp: TIMI 2 flow grade before PCI (1 for yes, 0 for no) timi_3_culprit_lesion_before_pci_hosp: TIMI 3 flow grade before PCI (1 for yes, 0 for no) stemi_inf_hosp: STEMI in the inferior wall (1 for yes, 0 for no) stemi_lat_hosp: STEMI in the lateral wall (1 for yes, 0 for no) stami_post_hosp: STEMI in the posterior wall (1 for yes, 0 for no) stami_ant_hosp: STEMI in the anterior wall (1 for yes, 0 for no) no_st_reduction_in_stemi_hosp: no reduction in ST elevation in STEMI (1 for yes, 0 for no) rv_mi_hosp: right ventricular myocardial infarction (1 for yes, 0 for no) nstemi_hosp: non-ST-elevation myocardial infarction (1 for yes, 0 for no) rbbb_hosp: right bundle branch block (1 for yes, 0 for no) sbp_admission_hosp: systolic blood pressure at admission, mm Hg dbp_admission_hosp: diastolic blood pressure at admission, mm Hg hr_admission_hosp: heart rate at admission, bpm pulmonary_edema_hosp: presence of pulmonary edema at admission (1 for yes, 0 for no) pulmonary_vascular_congestion_hosp: presence of pulmonary vascular congestion at admission (1 for yes, 0 for no) killip_1_hosp: Killip class 1 at admission (1 for yes, 0 for no) cardiac_arrest_hosp: history of cardiac arrest (1 for yes, 0 for no) ventricular_fibrillation_hosp: history of ventricular fibrillation (1 for yes, 0 for no) tnt_max_hosp: maximum troponin T level during hospitalization, ng/L abciximab_hosp: use of abciximab during hospitalization (1 for yes, 0 for no) eptifibatide_hosp: use of eptifibatide during hospitalization (1 for yes, 0 for no) another_mi_before_cpet_hosp: another myocardial infarction before cardiopulmonary exercise test (1 for yes, 0 for no) another_pci_before_cpet_hosp: another PCI before cardiopulmonary exercise test (1 for yes, 0 for no) another_ischamia_before_cpet_hosp: another ischemic event before cardiopulmonary exercise test (1 for yes, 0 for no) cabg_before_cpet_hosp: coronary artery bypass graft surgery before cardiopulmonary exercise test (1 for yes, 0 for no) planned_pci_non_mi_artery_before_cpet_hosp: planned PCI on non-MI artery before cardiopulmonary exercise test (1 for yes, 0 for no) grace_score_risk_in_hospitalization_hosp: GRACE score risk during hospitalization grace_score_risk_in_hospitalization_percent_hosp: GRACE score risk percentage during hospitalization, % wbc_discharge_hosp: white blood cell count at discharge rbc_discahrge_hosp: red blood cell count at discharge hgb_discharge_hosp: hemoglobin level at discharge, g/dL hct_discharge_hosp: hematocrit level at discharge, % sheet_1_weight_hosp: patient weight at discharge, kg creatinine_discharge_hosp: creatinine level at discharge, mg/dL gfr_cg_discharge_merged: glomerular filtration rate (Cockcroft-Gault equation) at discharge, mL/min/1.73m² acei_discharge_hosp: use of ACE inhibitors at discharge (1 for yes, 0 for no) arb_discharge_hosp: use of ARBs at discharge (1 for yes, 0 for no) bb_discharge_hosp: use of beta-blockers at discharge (1 for yes, 0 for no) asa_discharge_hosp: use of aspirin at discharge (1 for yes, 0 for no) clopidogrel_discharge_hosp: use of clopidogrel at discharge (1 for yes, 0 for no) ticagrelor_discharge_hosp: use of ticagrelor at discharge (1 for yes, 0 for no) statin_discharge_hosp: use of statins at discharge (1 for yes, 0 for no) nitrates_discharge_hosp: use of nitrates at discharge (1 for yes, 0 for no) cab_discharge_hosp: use of calcium channel blockers at discharge (1 for yes, 0 for no) diuretic_discharge_hosp: use of diuretics at discharge (1 for yes, 0 for no) echo_1_date_hosp: date of the first echocardiogram during hospitalization lax_lvedd_mm_hosp: left ventricular end-diastolic diameter (parasternal long axis view), mm lax_rvedd_mm_hosp: right ventricular end-diastolic diameter (parasternal long axis view), mm lax_ivsd_mm_hosp: interventricular septum diameter in diastole (parasternal long axis view), mm lax_pw_mm_hosp: posterior wall diameter in diastole (parasternal long axis view), mm lax_la_mm_hosp: left atrial diameter (parasternal long axis view), mm lax_ao_mm_hosp: aortic diameter (parasternal long axis view), mm x4c_lvedd_mm_hosp: left ventricular end-diastolic diameter (apical 4-chamber view), mm x4c_rvedd_bas_mm_hosp: right ventricular end-diastolic diameter at the base (apical 4-chamber view), mm x4c_la_mm_hosp: left atrial diameter (apical 4-chamber view), mm x4c_ra_mm_hosp: right atrial diameter (apical 4-chamber view), mm lvef_percent_hosp: left ventricular ejection fraction, % wmsi_hosp: wall motion score index tapse_mm_hosp: tricuspid annular plane systolic excursion, mm e_m_s_hosp: early diastolic mitral inflow velocity (E-wave), m/s a_m_s_hosp: late diastolic mitral inflow velocity (A-wave), m/s dect_ms_hosp: deceleration time of E-wave, ms e_prime_cm_s_hosp: early diastolic tissue velocity at the mitral annulus (e'), cm/s pulm_trunk_diam_mm_hosp: pulmonary trunk diameter, mm act_ms_hosp: pulmonary flow acceleration time, ms pv_velocity_m_s_hosp: pulmonary vein velocity, m/s ivc_expiration_mm_hosp: inferior vena cava diameter during expiration, mm ivc_inspiration_mm_hosp: inferior vena cava diameter during inspiration, mm ar_mild_hosp: presence of mild aortic regurgitation (1 for yes, 0 for no) ar_moderate_hosp: presence of moderate aortic regurgitation (1 for yes, 0 for no) as_mild_hosp: presence of mild aortic stenosis (1 for yes, 0 for no) mr_mild_hosp: presence of mild mitral regurgitation (1 for yes, 0 for no) mr_moderate_hosp: presence of moderate mitral regurgitation (1 for yes, 0 for no) mr_severe_hosp: presence of severe mitral regurgitation (1 for yes, 0 for no) tr_mild_hosp: presence of mild tricuspid regurgitation (1 for yes, 0 for no) tr_moderate_hosp: presence of moderate tricuspid regurgitation (1 for yes, 0 for no) trpg_rest_cpxe_1: tricuspid regurgitation pressure gradient at rest, mm Hg trpg_rest_more_30_mmhg_cpxe_1: tricuspid regurgitation pressure gradient &gt; 30 mm Hg at rest (1 for yes, 0 for no) ms_mild_rest_cpxe_1: presence of mild mitral stenosis at rest (1 for yes, 0 for no) ar_rest_cpxe_1: presence of aortic regurgitation at rest (1 for yes, 0 for no) lvot_vti_peak_cm_cpxe_1: left ventricular outflow tract velocity-time integral at peak exercise, cm sv_peak_ml_cpxe_1: stroke volume at peak exercise, mL co_peak_l_min_cpxe_1: cardiac output at peak exercise, L/min cardiac_index_peak_cpxe_1: cardiac index at peak exercise, L/min/m² wms_sume_peak_cpxe_1: wall motion score sum at peak exercise wmsi_peak_cpxe_1: wall motion score index at peak exercise ef_peak_percent_cpxe_1: ejection fraction at peak exercise, % lvedv_peak_ml_cpxe_1: left ventricular end-diastolic volume at peak exercise, mL lvesv_peak_ml_cpxe_1: left ventricular end-systolic volume at peak exercise, mL lvedv_index_peak_ml_m2_a_cpxe_1: left ventricular end-diastolic volume index at peak exercise, mL/m² (method A) lvedv_index_peak_ml_m2_b_cpxe_1: left ventricular end-diastolic volume index at peak exercise, mL/m² (method B) e_peak_m_s_cpxe_1: early diastolic mitral inflow velocity (E-wave) at peak exercise, m/s a_peak_m_s_cpxe_1: late diastolic mitral inflow velocity (A-wave) at peak exercise, m/s dt_peak_ms_cpxe_1: deceleration time of E-wave at peak exercise, ms tapse_peak_cm_cpxe_1: tricuspid annular plane systolic excursion at peak exercise, cm sm_rv_peak_cm_s_cpxe_1: peak systolic velocity of the right ventricular free wall, cm/s sm_ivs_peak_cm_s_cpxe_1: peak systolic velocity of the interventricular septum, cm/s em_ivs_peak_cm_s_cpxe_1: early diastolic tissue velocity at the interventricular septum (e'), cm/s am_ivs_peak_cm_s_cpxe_1: late diastolic tissue velocity at the interventricular septum (a'), cm/s sm_lat_peak_cm_s_cpxe_1: peak systolic velocity of the lateral wall, cm/s em_lat_peak_cm_s_cpxe_1: early diastolic tissue velocity at the lateral wall (e'), cm/s am_lat_peak_cm_s_cpxe_1: late diastolic tissue velocity at the lateral wall (a'), cm/s e_prime_aver_peak_cm_s_cpxe_1: average early diastolic tissue velocity at the mitral annulus (e'), cm/s e_e_prime_peak_cpxe_1: ratio of early diastolic mitral inflow velocity to early diastolic tissue velocity at peak exercise (E/e' ratio) mr_mild_pea_cpxe_1: presence of mild mitral regurgitation at peak exercise (1 for yes, 0 for no) mr_moderate_peak_cpxe_1: presence of moderate mitral regurgitation at peak exercise (1 for yes, 0 for no) mr_severe_peak_cpxe_1: presence of severe mitral regurgitation at peak exercise (1 for yes, 0 for no) tr_mild_peak_cpxe_1: presence of mild tricuspid regurgitation at peak exercise (1 for yes, 0 for no) tr_moderate_peak_cpxe_1: presence of moderate tricuspid regurgitation at peak exercise (1 for yes, 0 for no) trpg_peak_cpxe_1: tricuspid regurgitation pressure gradient at peak exercise, mm Hg trpg_peak_above_40_mmhg_cpxe_1: tricuspid regurgitation pressure gradient &gt; 40 mm Hg at peak exercise (1 for yes, 0 for no) vti_peak_minus_rest_cpxe_1: difference between peak and rest left ventricular outflow tract velocity-time integral, cm sv_peak_minus_rest_cpxe_1: difference between peak and rest stroke volume, mL co_peak_minus_rest_cpxe_1: difference between peak and rest cardiac output, L/min cardiac_index_peak_minus_rest_cpxe_1: difference between peak and rest cardiac index, L/min/m² ef_peak_minus_rest_cpxe_1: difference between peak and rest ejection fraction, % lvedv_peak_minus_rest_cpxe_1: difference between peak and rest left ventricular end-diastolic volume, mL lvesv_peak_minus_rest_cpxe_1: difference between peak and rest left ventricular end-systolic volume, mL e_e_prime_peak_minus_rest_cpxe_1: difference between peak and rest E/e' ratio sm_equation_peak_minus_rest_cpxe_1: difference between peak and rest systolic myocardial velocity calculated by a specific equation, cm/s tapse_peak_minus_rest_cpxe_1: difference between peak and rest tricuspid annular plane systolic excursion, cm sm_rv_peak_re_cpxe_1: peak systolic velocity of the right ventricular free wall relative to rest, cm/s end_syst_press_rest_cpxe_1: end-systolic pressure at rest, mm Hg end_syst_press_peak_cpxe_1: end-systolic pressure at peak exercise, mm Hg end_syst_press_dif_cpxe_1: difference between peak and rest end-systolic pressure, mm Hg map_rest_cpxe_1: mean arterial pressure at rest, mm Hg map_peak_cpxe_1: mean arterial pressure at peak exercise, mm Hg map_dif_cpxe_1: difference between peak and rest mean arterial pressure, mm Hg cardiac_power_output_rest_cpxe_1: cardiac power output at rest, W cardiac_power_output_peak_cpxe_1: cardiac power output at peak exercise, W cardiac_power_output_dif_cpxe_1: difference between peak and rest cardiac power output, W syst_vasc_resistance_rest_cpxe_1: systemic vascular resistance at rest, dyn·s/cm⁵ syst_vasc_resistance_peak_cpxe_1: systemic vascular resistance at peak exercise, dyn·s/cm⁵ syst_vasc_resistance_dif_cpxe_1: difference between peak and rest systemic vascular resistance, dyn·s/cm⁵ sbp_co_rest_mmhg_l_min_cpxe_1: systolic blood pressure divided by cardiac output at rest, mm Hg/L/min sbp_co_peak_mmhg_l_min_cpxe_1: systolic blood pressure divided by cardiac output at peak exercise, mm Hg/L/min sbp_co_dif_mmhg_l_min_cpxe_1: difference between peak and rest systolic blood pressure divided by cardiac output, mm Hg/L/min vo2_co_rest_cpxe_1: oxygen uptake to cardiac output ratio at rest, mL/min/L/min vo2_co_peak_cpxe_1: oxygen uptake to cardiac output ratio at peak exercise, mL/min/L/min vo2_co_dif_cpxe_1: difference between peak and rest oxygen uptake to cardiac output ratio, mL/min/L/min edv_e_e_ratio_rest_cpxe_1: end-diastolic volume to E/e' ratio at rest edv_e_e_prime_ratio_peak_cpxe_1: end-diastolic volume to E/e' ratio at peak exercise edv_e_e_prime_ratio_dif_cpxe_1: difference between peak and rest end-diastolic volume to E/e' ratio esp_esv_rest_cpxe_1: end-systolic pressure to end-systolic volume ratio at rest, mm Hg/mL esp_esv_peak_cpxe_1: end-systolic pressure to end-systolic volume ratio at peak exercise, mm Hg/mL esp_esv_dif_cpxe_1: difference between peak and rest end-systolic pressure to end-systolic volume ratio, mm Hg/mL double_prodact_peak_cpxe_1: double product (systolic blood pressure x heart rate) at peak exercise, mm Hg·bpm circ_power_cpxe_1: circulatory power at peak exercise, W exercise_card_power_cpxe_1: exercise cardiac power output at peak exercise, W vent_power_cpxe_1: ventilatory power at peak exercise new_mr_mod_peak_cpxe_1: new moderate mitral regurgitation at peak exercise (1 for yes, 0 for no) worsening_mr_peak_cpxe_1: worsening of mitral regurgitation at peak exercise (1 for yes, 0 for no) cpxe_2_3_cpxe_2: result of the second cardiopulmonary exercise test (1 for positive, 0 for negative) cpxe_2_4_cpxe_2: result of the second cardiopulmonary exercise test in another dimension (1 for positive, 0 for negative) age_cpxe_2: age at the time of the second cardiopulmonary exercise test, years height_cpxe_2: height at the time of the second cardiopulmonary exercise test, cm weight_cpxe_2: weight at the time of the second cardiopulmonary exercise test, kg bsa_cpxe_2: body surface area at the time of the second cardiopulmonary exercise test, m² ramp_cpxe_2: ramp protocol used during the second cardiopulmonary exercise test czas_wysilku_min_cpxe_2: exercise duration during the second cardiopulmonary exercise test, minutes czas_wysilku_sek_cpxe_2: exercise duration during the second cardiopulmonary exercise test, seconds exercise_time_sec_cpxe_2: total exercise time during the second cardiopulmonary exercise test, seconds sbp_maxload_cpxe_2: systolic blood pressure at maximum load during the second cardiopulmonary exercise test, mm Hg dbp_maxload_cpxe_2: diastolic blood pressure at maximum load during the second cardiopulmonary exercise test, mm Hg load_max_pred_watts_cpxe_2: predicted maximum load in watts during the second cardiopulmonary exercise test load_at_watts_cpxe_2: load at anaerobic threshold during the second cardiopulmonary exercise test, watts load_max_watts_cpxe_2: maximum load during the second cardiopulmonary exercise test, watts vo2_max_pred_l_min_cpxe_2: predicted maximum oxygen uptake during the second cardiopulmonary exercise test, L/min vo2_rest_l_min_cpxe_2: oxygen uptake at rest during the second cardiopulmonary exercise test, L/min vo2_at_l_min_cpxe_2: oxygen uptake at anaerobic threshold during the second cardiopulmonary exercise test, L/min vo2_at_l_kg_min_cpxe_2: oxygen uptake at anaerobic threshold per kg of body weight during the second cardiopulmonary exercise test, mL/kg/min vo2_maxload_l_min_cpxe_2: oxygen uptake at maximum load during the second cardiopulmonary exercise test, L/min vo2_maxload_l_kg_min_cpxe_2: oxygen uptake at maximum load per kg of body weight during the second cardiopulmonary exercise test, mL/kg/min max_load_vo2_perc_pred_cpxe_2: percentage of predicted maximum oxygen uptake achieved during the second cardiopulmonary exercise test vco2_max_pred_l_min_cpxe_2: predicted maximum carbon dioxide output during the second cardiopulmonary exercise test, L/min vco2_rest_l_min_cpxe_2: carbon dioxide output at rest during the second cardiopulmonary exercise test, L/min vco2_at_l_min_cpxe_2: carbon dioxide output at anaerobic threshold during the second cardiopulmonary exercise test, L/min vco2_maxload_l_min_cpxe_2: carbon dioxide output at maximum load during the second cardiopulmonary exercise test, L/min rer_rest_cpxe_2: respiratory exchange ratio at rest during the second cardiopulmonary exercise test rer_at_cpxe_2: respiratory exchange ratio at anaerobic threshold during the second cardiopulmonary exercise test rer_maxload_cpxe_2: respiratory exchange ratio at maximum load during the second cardiopulmonary exercise test hr_max_pred_bpm_cpxe_2: predicted maximum heart rate during the second cardiopulmonary exercise test, bpm hr_rest_bpm_cpxe_2: heart rate at rest during the second cardiopulmonary exercise test, bpm hr_at_bpm_cpxe_2: heart rate at anaerobic threshold during the second cardiopulmonary exercise test, bpm hr_maxload_bpm_cpxe_2: heart rate at maximum load during the second cardiopulmonary exercise test, bpm hr_proc_pred_peak_cpxe_2: percentage of predicted maximum heart rate achieved during the second cardiopulmonary exercise test chron_index_cpxe_2: chronotropic index calculated as ([achieved maximal HR − resting HR] / [age‐predicted maximal HR − resting HR]) o2_pulse_max_pred_cpxe_2: predicted oxygen pulse during the second cardiopulmonary exercise test, mL/beat o2_pulse_rest_cpxe_2: oxygen pulse at rest during the second cardiopulmonary exercise test, mL/beat o2_pulse_at_cpxe_2: oxygen pulse at anaerobic threshold during the second cardiopulmonary exercise test, mL/beat o2_pulse_maxload_cpxe_2: oxygen pulse at maximum load during the second cardiopulmonary exercise test, mL/beat sbp_rest_mmhg_cpxe_2: systolic blood pressure at rest during the second cardiopulmonary exercise test, mm Hg dbp_rest_mmhg_cpxe_2: diastolic blood pressure at rest during the second cardiopulmonary exercise test, mm Hg sbp_at_mmhg_cpxe_2: systolic blood pressure at anaerobic threshold during the second cardiopulmonary exercise test, mm Hg dbp_at_mmhg_cpxe_2: diastolic blood pressure at anaerobic threshold during the second cardiopulmonary exercise test, mm Hg ve_maxpred_cpxe_2: predicted maximum minute ventilation during the second cardiopulmonary exercise test, L/min ve_rest_cpxe_2: minute ventilation at rest during the second cardiopulmonary exercise test, L/min ve_at_cpxe_2: minute ventilation at anaerobic threshold during the second cardiopulmonary exercise test, L/min ve_maxload_cpxe_2: minute ventilation at maximum load during the second cardiopulmonary exercise test, L/min ve_perc_pred_cpxe_2: percentage of predicted minute ventilation achieved during the second cardiopulmonary exercise test vt_pred_cpxe_2: predicted tidal volume during the second cardiopulmonary exercise test, L vt_rest_cpxe_2: tidal volume at rest during the second cardiopulmonary exercise test, L vt_at_cpxe_2: tidal volume at anaerobic threshold during the second cardiopulmonary exercise test, L vt_maxload_cpxe_2: tidal volume at maximum load during the second cardiopulmonary exercise test, L vt_proc_pred_cpxe_2: percentage of predicted tidal volume achieved during the second cardiopulmonary exercise test bf_pred_cpxe_2: predicted breathing frequency during the second cardiopulmonary exercise test, breaths/min bf_rest_cpxe_2: breathing frequency at rest during the second cardiopulmonary exercise test, breaths/min bf_at_cpxe_2: breathing frequency at anaerobic threshold during the second cardiopulmonary exercise test, breaths/min bf_maxload_cpxe_2: breathing frequency at maximum load during the second cardiopulmonary exercise test, breaths/min br_rest_cpxe_2: breathing reserve at rest during the second cardiopulmonary exercise test, % br_at_cpxe_2: breathing reserve at anaerobic threshold during the second cardiopulmonary exercise test, % br_maxload_cpxe_2: breathing reserve at maximum load during the second cardiopulmonary exercise test, % vd_vt_rest_cpxe_2: dead space to tidal volume ratio at rest during the second cardiopulmonary exercise test vd_vt_at_cpxe_2: dead space to tidal volume ratio at anaerobic threshold during the second cardiopulmonary exercise test vd_vt_maxload_cpxe_2: dead space to tidal volume ratio at maximum load during the second cardiopulmonary exercise test eqo2_rest_cpxe_2: oxygen equivalent at rest during the second cardiopulmonary exercise test eqo2_at_cpxe_2: oxygen equivalent at anaerobic threshold during the second cardiopulmonary exercise test eqo2_maxload_cpxe_2: oxygen equivalent at maximum load during the second cardiopulmonary exercise test eqco2_rest_cpxe_2: carbon dioxide equivalent at rest during the second cardiopulmonary exercise test eqco2_at_cpxe_2: carbon dioxide equivalent at anaerobic threshold during the second cardiopulmonary exercise test eqco2_maxload_cpxe_2: carbon dioxide equivalent at maximum load during the second cardiopulmonary exercise test peto2_rest_cpxe_2: partial pressure of end-tidal oxygen at rest during the second cardiopulmonary exercise test, mm Hg peto2_at_cpxe_2: partial pressure of end-tidal oxygen at anaerobic threshold during the second cardiopulmonary exercise test, mm Hg peto2_maxload_cpxe_2: partial pressure of end-tidal oxygen at maximum load during the second cardiopulmonary exercise test, mm Hg petco2_rest_cpxe_2: partial pressure of end-tidal carbon dioxide at rest during the second cardiopulmonary exercise test, mm Hg petco2_at_cpxe_2: partial pressure of end-tidal carbon dioxide at anaerobic threshold during the second cardiopulmonary exercise test, mm Hg petco2_maxload_cpxe_2: partial pressure of end-tidal carbon dioxide at maximum load during the second cardiopulmonary exercise test, mm Hg dvo2_dwr_cpxe_2: oxygen uptake to work rate ratio during the second cardiopulmonary exercise test, mL/min/W oues_cpxe_2: oxygen uptake efficiency slope during the second cardiopulmonary exercise test ve_o2_slope_cpxe_2: minute ventilation versus oxygen uptake slope during the second cardiopulmonary exercise test ve_vco2_slope_cpxe_2: minute ventilation versus carbon dioxide output slope during the second cardiopulmonary exercise test ivc_pred_cpxe_2: predicted inspiratory vital capacity during the second cardiopulmonary exercise test, % ivc_act_cpxe_2: actual inspiratory vital capacity during the second cardiopulmonary exercise test, L ivc_proc_pred_cpxe_2: percentage of predicted inspiratory vital capacity achieved during the second cardiopulmonary exercise test fev1_pred_cpxe_2: predicted forced expiratory volume in the first second during the second cardiopulmonary exercise test, % fev1_act_cpxe_2: actual forced expiratory volume in the first second during the second cardiopulmonary exercise test, L fev1_proc_pred_cpxe_2: percentage of predicted forced expiratory volume in the first second achieved during the second cardiopulmonary exercise test fev1_ivc_pred_cpxe_2: predicted ratio of FEV1 to inspiratory vital capacity during the second cardiopulmonary exercise test, % fev1_ivc_act_cpxe_2: actual ratio of FEV1 to inspiratory vital capacity during the second cardiopulmonary exercise test fev1_vc_perc_pred_cpxe_2: percentage of predicted FEV1 to vital capacity ratio achieved during the second cardiopulmonary exercise test ese_1_date_cpxe_2: date of the first stress echocardiogram ese_1_number_cpxe_2: identifier for the first stress echocardiogram lvot_diam_1_cpxe_2: left ventricular outflow tract diameter, first measurement, cm lvot_diam_2_cpxe_2: left ventricular outflow tract diameter, second measurement, cm lvot_diam_aver_cpxe_2: average left ventricular outflow tract diameter, cm lvot_vti_rest_cm_cpxe_2: left ventricular outflow tract velocity-time integral at rest, cm sv_rest_ml_cpxe_2: stroke volume at rest, mL co_rest_l_min_cpxe_2: cardiac output at rest, L/min cardiac_index_rest_cpxe_2: cardiac index at rest, L/min/m² wms_sume_rest_cpxe_2: wall motion score sum at rest wmsi_rest_cpxe_2: wall motion score index at rest ef_rest_prec_cpxe_2: ejection fraction at rest, % lvedv_rest_ml_cpxe_2: left ventricular end-diastolic volume at rest, mL lvesv_bp_rest_ml_cpxe_2: left ventricular end-systolic volume at rest, mL lvedv_index_rest_ml_m2_cpxe_2: left ventricular end-diastolic volume index at rest, mL/m² lvesv_index_rest_ml_m2_cpxe_2: left ventricular end-systolic volume index at rest, mL/m² e_rest_m_sec_cpxe_2: early diastolic mitral inflow velocity (E-wave) at rest, m/s a_rest_m_sec_cpxe_2: late diastolic mitral inflow velocity (A-wave) at rest, m/s dt_rest_ms_cpxe_2: deceleration time of E-wave at rest, ms tapse_rest_cm_cpxe_2: tricuspid annular plane systolic excursion at rest, cm sm_rv_rest_cm_s_cpxe_2: systolic myocardial velocity of the right ventricular free wall at rest, cm/s sm_ivs_rest_cm_s_cpxe_2: systolic myocardial velocity of the interventricular septum at rest, cm/s em_ivs_rest_cm_s_cpxe_2: early diastolic myocardial velocity of the interventricular septum at rest, cm/s am_ivs_rest_cm_s_cpxe_2: late diastolic myocardial velocity of the interventricular septum at rest, cm/s sm_lat_rest_cm_s_cpxe_2: systolic myocardial velocity of the lateral wall at rest, cm/s em_lat_rest_cm_s_cpxe_2: early diastolic myocardial velocity of the lateral wall at rest, cm/s am_lat_rest_cm_s_cpxe_2: late diastolic myocardial velocity of the lateral wall at rest, cm/s e_prime_aver_rest_cm_s_cpxe_2: average early diastolic myocardial velocity at the mitral annulus at rest (e'), cm/s e_e_prime_rest_cpxe_2: ratio of early diastolic mitral inflow velocity to early diastolic tissue velocity at rest (E/e' ratio) mr_mild_rest_cpxe_2: presence of mild mitral regurgitation at rest (1 for yes, 0 for no) mr_moderate_rest_cpxe_2: presence of moderate mitral regurgitation at rest (1 for yes, 0 for no) mr_severe_rest_cpxe_2: presence of severe mitral regurgitation at rest (1 for yes, 0 for no) tr_mild_rest_cpxe_2: presence of mild tricuspid regurgitation at rest (1 for yes, 0 for no) trpg_rest_cpxe_2: tricuspid regurgitation pressure gradient at rest during the second cardiopulmonary exercise test, mm Hg trpg_rest_30_mm_hg_cpxe_2: tricuspid regurgitation pressure gradient &gt; 30 mm Hg at rest during the second cardiopulmonary exercise test (1 for yes, 0 for no) ms_mild_rest_cpxe_2: presence of mild mitral stenosis at rest during the second cardiopulmonary exercise test (1 for yes, 0 for no) ar_rest_cpxe_2: presence of aortic regurgitation at rest during the second cardiopulmonary exercise test (1 for yes, 0 for no) lvot_vti_peak_cm_cpxe_2: left ventricular outflow tract velocity-time integral at peak exercise during the second cardiopulmonary exercise test, cm sv_peak_ml_cpxe_2: stroke volume at peak exercise during the second cardiopulmonary exercise test, mL co_peak_l_min_cpxe_2: cardiac output at peak exercise during the second cardiopulmonary exercise test, L/min cardiac_index_peak_cpxe_2: cardiac index at peak exercise during the second cardiopulmonary exercise test, L/min/m² wms_sume_peak_cpxe_2: wall motion score sum at peak exercise during the second cardiopulmonary exercise test wmsi_peak_cpxe_2: wall motion score index at peak exercise during the second cardiopulmonary exercise test ef_peak_percent_cpxe_2: ejection fraction at peak exercise during the second cardiopulmonary exercise test, % lvedv_peak_ml_cpxe_2: left ventricular end-diastolic volume at peak exercise during the second cardiopulmonary exercise test, mL lvesv_peak_ml_cpxe_2: left ventricular end-systolic volume at peak exercise during the second cardiopulmonary exercise test, mL lvedv_index_peak_ml_m2_139_cpxe_2: left ventricular end-diastolic volume index at peak exercise (method A), mL/m² lvedv_index_peak_ml_m2_140_cpxe_2: left ventricular end-diastolic volume index at peak exercise (method B), mL/m² e_2_peak_m_s_cpxe_2: early diastolic mitral inflow velocity (E-wave) at peak exercise during the second cardiopulmonary exercise test, m/s a_2_peak_m_s_cpxe_2: late diastolic mitral inflow velocity (A-wave) at peak exercise during the second cardiopulmonary exercise test, m/s dt_2peak_ms_cpxe_2: deceleration time of E-wave at peak exercise during the second cardiopulmonary exercise test, ms tapse_2_peak_cm_cpxe_2: tricuspid annular plane systolic excursion at peak exercise during the second cardiopulmonary exercise test, cm sm_rv_2_peak_cm_s_cpxe_2: peak systolic velocity of the right ventricular free wall during the second cardiopulmonary exercise test, cm/s sm_ivs_2_peak_cm_s_cpxe_2: peak systolic velocity of the interventricular septum during the second cardiopulmonary exercise test, cm/s em_ivs_2_peak_cm_s_cpxe_2: early diastolic tissue velocity of the interventricular septum during the second cardiopulmonary exercise test, cm/s am_ivs_2_peak_cm_s_cpxe_2: late diastolic tissue velocity of the interventricular septum during the second cardiopulmonary exercise test, cm/s sm_lat_2_peak_cm_s_cpxe_2: peak systolic velocity of the lateral wall during the second cardiopulmonary exercise test, cm/s em_lat_2_peak_cm_s_cpxe_2: early diastolic tissue velocity of the lateral wall during the second cardiopulmonary exercise test, cm/s am_lat_2_peak_cm_s_cpxe_2: late diastolic tissue velocity of the lateral wall during the second cardiopulmonary exercise test, cm/s e_aver_2_peak_cm_s_cpxe_2: average early diastolic tissue velocity at the mitral annulus at peak exercise during the second cardiopulmonary exercise test (e'), cm/s e_e_peak_2_cpxe_2: ratio of early diastolic mitral inflow velocity to early diastolic tissue velocity at peak exercise during the second cardiopulmonary exercise test (E/e' ratio) mr_2_mild_peak_cpxe_2: presence of mild mitral regurgitation at peak exercise during the second cardiopulmonary exercise test (1 for yes, 0 for no) mr_2_moderate_peak_cpxe_2: presence of moderate mitral regurgitation at peak exercise during the second cardiopulmonary exercise test (1 for yes, 0 for no) mr_2_severe_peak_cpxe_2: presence of severe mitral regurgitation at peak exercise during the second cardiopulmonary exercise test (1 for yes, 0 for no) tr_2_mild_peak_cpxe_2: presence of mild tricuspid regurgitation at peak exercise during the second cardiopulmonary exercise test (1 for yes, 0 for no) tr_2_moderate_peak_cpxe_2: presence of moderate tricuspid regurgitation at peak exercise during the second cardiopulmonary exercise test (1 for yes, 0 for no) tr_2_severe_peak_cpxe_2: presence of severe tricuspid regurgitation at peak exercise during the second cardiopulmonary exercise test (1 for yes, 0 for no) trpg_peak_cpxe_2: tricuspid regurgitation pressure gradient at peak exercise during the second cardiopulmonary exercise test, mm Hg trpg_peak_above_40_mm_hg_cpxe_2: tricuspid regurgitation pressure gradient &gt; 40 mm Hg at peak exercise during the second cardiopulmonary exercise test (1 for yes, 0 for no) vti_peak_rest_2_cpxe_2: difference between peak and rest left ventricular outflow tract velocity-time integral during the second cardiopulmonary exercise test, cm sv_peak_rest_2_cpxe_2: difference between peak and rest stroke volume during the second cardiopulmonary exercise test, mL co_peak_rest_2_cpxe_2: difference between peak and rest cardiac output during the second cardiopulmonary exercise test, L/min cardiac_index_peak_rest_2_cpxe_2: difference between peak and rest cardiac index during the second cardiopulmonary exercise test, L/min/m² ef_peak_rest_2_cpxe_2: difference between peak and rest ejection fraction during the second cardiopulmonary exercise test, % lvedv_peak_rest_2_cpxe_2: difference between peak and rest left ventricular end-diastolic volume during the second cardiopulmonary exercise test, mL lvesv_peak_rest_2_cpxe_2: difference between peak and rest left ventricular end-systolic volume during the second cardiopulmonary exercise test, mL e_e_peak_rest_2_cpxe_2: difference between peak and rest E/e' ratio during the second cardiopulmonary exercise test sm_ivs_lat_2_peak_rest_2_cpxe_2: difference between peak and rest systolic myocardial velocity of the interventricular septum during the second cardiopulmonary exercise test, cm/s tapse_peak_rest_2_cpxe_2: difference between peak and rest tricuspid annular plane systolic excursion during the second cardiopulmonary exercise test, cm sm_rv_peak_re_cpxe_2: difference between peak and rest systolic myocardial velocity of the right ventricular free wall during the second cardiopulmonary exercise test, cm/s end_syst_press_rest_cpxe_2: end-systolic pressure at rest during the second cardiopulmonary exercise test, mm Hg end_syst_press_peak_cpxe_2: end-systolic pressure at peak exercise during the second cardiopulmonary exercise test, mm Hg end_syst_press_dif_cpxe_2: difference between peak and rest end-systolic pressure during the second cardiopulmonary exercise test, mm Hg map_rest_cpxe_2: mean arterial pressure at rest during the second cardiopulmonary exercise test, mm Hg map_peak_cpxe_2: mean arterial pressure at peak exercise during the second cardiopulmonary exercise test, mm Hg map_dif_cpxe_2: difference between peak and rest mean arterial pressure during the second cardiopulmonary exercise test, mm Hg cardiac_power_output_rest_cpxe_2: cardiac power output at rest during the second cardiopulmonary exercise test, W cardiac_power_output_peak_cpxe_2: cardiac power output at peak exercise during the second cardiopulmonary exercise test, W cardiac_power_output_dif_cpxe_2: difference between peak and rest cardiac power output during the second cardiopulmonary exercise test, W syst_vasc_resistance_rest_cpxe_2: systemic vascular resistance at rest during the second cardiopulmonary exercise test, dyn·s/cm⁵ syst_vasc_resistance_peak_cpxe_2: systemic vascular resistance at peak exercise during the second cardiopulmonary exercise test, dyn·s/cm⁵ syst_vasc_resistance_dif_cpxe_2: difference between peak and rest systemic vascular resistance during the second cardiopulmonary exercise test, dyn·s/cm⁵ sbp_co_rest_mmhg_l_min_cpxe_2: systolic blood pressure divided by cardiac output at rest during the second cardiopulmonary exercise test, mm Hg/L/min sbp_co_peak_mmhg_l_min_cpxe_2: systolic blood pressure divided by cardiac output at peak exercise during the second cardiopulmonary exercise test, mm Hg/L/min sbp_co_dif_mmhg_l_min_cpxe_2: difference between peak and rest systolic blood pressure divided by cardiac output during the second cardiopulmonary exercise test, mm Hg/L/min vo2_co_rest_cpxe_2: oxygen uptake to cardiac output ratio at rest during the second cardiopulmonary exercise test, mL/min/L/min vo2_co_peak_cpxe_2: oxygen uptake to cardiac output ratio at peak exercise during the second cardiopulmonary exercise test, mL/min/L/min vo2_co_dif_cpxe_2: difference between peak and rest oxygen uptake to cardiac output ratio during the second cardiopulmonary exercise test, mL/min/L/min edv_e_e_ratio_rest_cpxe_2: end-diastolic volume to E/e' ratio at rest during the second cardiopulmonary exercise test edv_e_e_ratio_peak_cpxe_2: end-diastolic volume to E/e' ratio at peak exercise during the second cardiopulmonary exercise test edv_e_e_ratio_dif_cpxe_2: difference between peak and rest end-diastolic volume to E/e' ratio during the second cardiopulmonary exercise test esp_esv_rest_cpxe_2: end-systolic pressure to end-systolic volume ratio at rest during the second cardiopulmonary exercise test, mm Hg/mL esp_esv_peak_cpxe_2: end-systolic pressure to end-systolic volume ratio at peak exercise during the second cardiopulmonary exercise test, mm Hg/mL esp_esv_dif_cpxe_2: difference between peak and rest end-systolic pressure to end-systolic volume ratio during the second cardiopulmonary exercise test, mm Hg/mL double_prodact_peak_cpxe_2: double product (systolic blood pressure x heart rate) at peak exercise during the second cardiopulmonary exercise test, mm Hg·bpm circ_power_cpxe_2: circulatory power at peak exercise during the second cardiopulmonary exercise test, W exercise_card_power_cpxe_2: exercise cardiac power output at peak exercise during the second cardiopulmonary exercise test, W vent_power_cpxe_2: ventilatory power at peak exercise during the second cardiopulmonary exercise test new_mr_mod_peak_cpxe_2: new moderate mitral regurgitation at peak exercise during the second cardiopulmonary exercise test (1 for yes, 0 for no) worsening_mr_peak_cpxe_2: worsening of mitral regurgitation at peak exercise during the second cardiopulmonary exercise test (1 for yes, 0 for no) cpxe_1_reh: result of the first cardiopulmonary exercise test in rehabilitation (1 for positive, 0 for negative) cpxe_2_reh: result of the second cardiopulmonary exercise test in rehabilitation (1 for positive, 0 for negative) cr_k_reh: result of creatinine test in rehabilitation (1 for normal, 0 for abnormal) cr_ik_reh: result of creatinine kinase test in rehabilitation (1 for normal, 0 for abnormal) rehab_reh: participation in a rehabilitation program (1 for yes, 0 for no) k_2x_reh: number of sessions per week in the rehabilitation program ik_2x_reh: number of weeks in the rehabilitation program karta_informacyjna_1_jest_0_brak_reh: presence of an informational card (1 for yes, 0 for no) x6mwt_liczba_reh: number of six-minute walk tests conducted during rehabilitation x6mwt_1_hr_rest_reh: heart rate at rest during the first six-minute walk test in rehabilitation, bpm x6mwt_1_sbp_rest_reh: systolic blood pressure at rest during the first six-minute walk test in rehabilitation, mm Hg x6mwt_1_dbp_rest_reh: diastolic blood pressure at rest during the first six-minute walk test in rehabilitation, mm Hg x6mwt_1_hr_exerc_reh: heart rate during exercise in the first six-minute walk test in rehabilitation, bpm x6mwt_1_sbp_exerc_reh: systolic blood pressure during exercise in the first six-minute walk test in rehabilitation, mm Hg x6mwt_1_dbp_exerc_reh: diastolic blood pressure during exercise in the first six-minute walk test in rehabilitation, mm Hg x6mwt_1_dystans_m_reh: distance covered in the first six-minute walk test in rehabilitation, meters x6mwt_1_bol_w_klp_reh: presence of chest pain during the first six-minute walk test in rehabilitation (1 for yes, 0 for no) x6mwt_2_hr_rest_reh: heart rate at rest during the second six-minute walk test in rehabilitation, bpm x6mwt_2sbp_rest_reh: systolic blood pressure at rest during the second six-minute walk test in rehabilitation, mm Hg x6mwt_2_dbp_rest_reh: diastolic blood pressure at rest during the second six-minute walk test in rehabilitation, mm Hg x6mwt_2_hr_exerc_reh: heart rate during exercise in the second six-minute walk test in rehabilitation, bpm x6mwt_2_sbp_exers_reh: systolic blood pressure during exercise in the second six-minute walk test in rehabilitation, mm Hg x6mwt_2_dbp_exerc_reh: diastolic blood pressure during exercise in the second six-minute walk test in rehabilitation, mm Hg dystans_m_reh: total distance covered in the six-minute walk test during rehabilitation, meters bol_w_klp_reh: presence of chest pain during the six-minute walk test in rehabilitation (1 for yes, 0 for no) model_rehab_poczatkowy_reh: initial rehabilitation model (categorical code) model_rehab_koncowy_reh: final rehabilitation model (categorical code) liczba_testow_ergo_reh: number of ergometry tests conducted during rehabilitation ex_t1_hr_rest_reh: heart rate at rest during the first ergometry test in rehabilitation, bpm ex_t1_sbp_reh: systolic blood pressure during the first ergometry test in rehabilitation, mm Hg ex_t1dbp_36_reh: diastolic blood pressure during the first ergometry test in rehabilitation, mm Hg ex_t1hr_reh: heart rate during exercise in the first ergometry test in rehabilitation, bpm ex_t1sbp_reh: systolic blood pressure during exercise in the first ergometry test in rehabilitation, mm Hg ex_t1dbp_39_reh: diastolic blood pressure during exercise in the first ergometry test in rehabilitation, mm Hg ex_t1_met_reh: metabolic equivalent during the first ergometry test in rehabilitation ex_t1_bol_w_klp_reh: presence of chest pain during the first ergometry test in rehabilitation (1 for yes, 0 for no) ex_t2_hr_rest_reh: heart rate at rest during the second ergometry test in rehabilitation, bpm ex_t2_sbp_43_reh: systolic blood pressure during the second ergometry test in rehabilitation, mm Hg ex_t2_dbp_44_reh: diastolic blood pressure during the second ergometry test in rehabilitation, mm Hg ex_t2_hr_reh: heart rate during exercise in the second ergometry test in rehabilitation, bpm ex_t2_sbp_46_reh: systolic blood pressure during exercise in the second ergometry test in rehabilitation, mm Hg ex_t2_dbp_47_reh: diastolic blood pressure during exercise in the second ergometry test in rehabilitation, mm Hg ex_t2_met_reh: metabolic equivalent during the second ergometry test in rehabilitation lliczba_treningow_reh: number of training sessions conducted during rehabilitation limit_tetna_treningowego_reh: heart rate limit set for training during rehabilitation max_obciazeni_etreningowe_w_reh: maximum load achieved during training in rehabilitation, watts asa_dawka_reh: dose of aspirin administered during rehabilitation, mg asa_liczba_tabletek_reh: number of aspirin tablets administered during rehabilitation p_plt_nazwa_reh: name of platelet inhibitor medication used during rehabilitation p_plt_dawka_reh: dose of platelet inhibitor medication used during rehabilitation, mg p_plt_liczba_tabletek_reh: number of platelet inhibitor tablets administered during rehabilitation b_bloker_reh: use of beta-blockers during rehabilitation (1 for yes, 0 for no) b_bloker_dawka_reh: dose of beta-blockers administered during rehabilitation, mg b_bloker_liczba_tabletek_reh: number of beta-blocker tablets administered during rehabilitation statyna_reh: use of statins during rehabilitation (1 for yes, 0 for no) statyna_dawka_reh: dose of statins administered during rehabilitation, mg acei_arb_reh: use of ACE inhibitors or ARBs during rehabilitation (1 for yes, 0 for no) acei_arb_dawka_reh: dose of ACE inhibitors or ARBs administered during rehabilitation, mg acei_arb_liczba_tabletek_reh: number of ACE inhibitor or ARB tablets administered during rehabilitation ca_bloker_reh: use of calcium channel blockers during rehabilitation (1 for yes, 0 for no) ca_blok_dawka_reh: dose of calcium channel blockers administered during rehabilitation, mg ca_blok_liczba_tabletek_reh: number of calcium channel blocker tablets administered during rehabilitation diuretuk_reh: use of diuretics during rehabilitation (1 for yes, 0 for no) diuret_dawka_reh: dose of diuretics administered during rehabilitation, mg diuretyk_liczba_tabletek_reh: number of diuretic tablets administered during rehabilitation nazwa_reh: name of any other medication administered during rehabilitation dawka_reh: dose of any other medication administered during rehabilitation, mg liczba_tabletek_reh: number of any other medication tablets administered during rehabilitation ankieta_i_ankieta_1_i_2: presence of completed questionnaires 1 and 2 (1 for yes, 0 for no) godzina_5_ankieta_1_i_2: hour of questionnaire completion (format to be defined) zawod_6_ankieta_1_i_2: occupation of the patient (categorical code) aktywnosc_fizyczna_po_zawale_1_mala_2_umiarkowana_3_duza_ankieta_1_i_2: physical activity level after myocardial infarction (1 for low, 2 for moderate, 3 for high) papierosy_aktualnie_1_tak_0_nie_ankieta_1_i_2: current smoking status (1 for yes, 0 for no) ile_na_dobe_12_ankieta_1_i_2: number of cigarettes smoked per day przez_ile_lat_13_ankieta_1_i_2: number of years smoking papierosy_w_przeszlosci_1_roku_1_tak_0_nie_ankieta_1_i_2: history of smoking within the past year (1 for yes, 0 for no) ile_na_dobe_15_ankieta_1_i_2: number of cigarettes smoked per day in the past year przez_ile_lat_16_ankieta_1_i_2: number of years smoking in the past year astma_po_ch_p_17_ankieta_1_i_2: history of asthma or COPD (1 for yes, 0 for no) inne_choroby_pluc_18_ankieta_1_i_2: history of other lung diseases (1 for yes, 0 for no) ao_miazdzyca_tt_obwodowych_19_ankieta_1_i_2: history of atherosclerosis in peripheral arteries (1 for yes, 0 for no) inne_choroby_tetnic_obwodowych_20_ankieta_1_i_2: history of other peripheral arterial diseases (1 for yes, 0 for no) choroba_zwyrodnieniowa_stawow_ograniczajaca_aktywnosc_21_ankieta_1_i_2: history of osteoarthritis limiting physical activity (1 for yes, 0 for no) choroba_zwyrodnieniowa_stawow_nie_ograniczajaca_aktywnosci_22_ankieta_1_i_2: history of osteoarthritis not limiting physical activity (1 for yes, 0 for no) nadcisnienie_tetnicze_23_ankieta_1_i_2: history of hypertension (1 for yes, 0 for no) cukrzyca_typ_i_24_ankieta_1_i_2: history of type 1 diabetes mellitus (1 for yes, 0 for no) cukrzyca_typ_ii_25_ankieta_1_i_2: history of type 2 diabetes mellitus (1 for yes, 0 for no) hiperlipidemia_26_ankieta_1_i_2: history of hyperlipidemia (1 for yes, 0 for no) przewlekla_choroba_nerek_27_ankieta_1_i_2: history of chronic kidney disease (1 for yes, 0 for no) subiektywna_poprawa_wydolnosci_po_rehabilitacji_kardiologicznej_w_stosunku_do_okresu_po_zawale_28_ankieta_1_i_2: subjective improvement in exercise capacity after cardiac rehabilitation compared to the post-MI period (1 for yes, 0 for no) godzina_przyjecia_b_blokera_przed_testem_29_ankieta_1_i_2: time of beta-blocker administration before the test ankieta_ii_ankieta_1_i_2: presence of completed second questionnaire (1 for yes, 0 for no) godzina_32_ankieta_1_i_2: hour of completion of the second questionnaire (format to be defined) zawod_33_ankieta_1_i_2: occupation of the patient in the second questionnaire (categorical code) aktywnosc_fizyczna_po_zawale_ankieta_1_i_2: physical activity level after myocardial infarction according to the second questionnaire (categorical code) papierosy_aktualnie_ankieta_1_i_2: current smoking status in the second questionnaire (1 for yes, 0 for no) ile_na_dobe_39_ankieta_1_i_2: number of cigarettes smoked per day in the second questionnaire przez_ile_lat_40_ankieta_1_i_2: number of years smoking in the second questionnaire papierosy_w_przeszlosci_1_roku_ankieta_1_i_2: history of smoking within the past year according to the second questionnaire (1 for yes, 0 for no) ile_na_dobe_42_ankieta_1_i_2: number of cigarettes smoked per day in the past year according to the second questionnaire przez_ile_lat_43_ankieta_1_i_2: number of years smoking in the past year according to the second questionnaire astma_po_ch_p_44_ankieta_1_i_2: history of asthma or COPD according to the second questionnaire (1 for yes, 0 for no) inne_choroby_pluc_45_ankieta_1_i_2: history of other lung diseases according to the second questionnaire (1 for yes, 0 for no) ao_miazdzyca_tt_obwodowych_46_ankieta_1_i_2: history of atherosclerosis in peripheral arteries according to the second questionnaire (1 for yes, 0 for no) inne_choroby_tetnic_obwodowych_47_ankieta_1_i_2: history of other peripheral arterial diseases according to the second questionnaire (1 for yes, 0 for no) choroba_zwyrodnieniowa_stawow_ograniczajaca_aktywnosc_48_ankieta_1_i_2: history of osteoarthritis limiting physical activity according to the second questionnaire (1 for yes, 0 for no) choroba_zwyrodnieniowa_stawow_nie_ograniczajaca_aktywnosci_49_ankieta_1_i_2: history of osteoarthritis not limiting physical activity according to the second questionnaire (1 for yes, 0 for no) nadcisnienie_tetnicze_50_ankieta_1_i_2: history of hypertension according to the second questionnaire (1 for yes, 0 for no) cukrzyca_typ_ii_52_ankieta_1_i_2: history of type 2 diabetes mellitus according to the second questionnaire (1 for yes, 0 for no) hiperlipidemia_53_ankieta_1_i_2: history of hyperlipidemia according to the second questionnaire (1 for yes, 0 for no) przewlekla_choroba_nerek_54_ankieta_1_i_2: history of chronic kidney disease according to the second questionnaire (1 for yes, 0 for no) subiektywna_poprawa_wydolnosci_po_rehabilitacji_kardiologicznej_w_stosunku_do_okresu_po_zawale_55_ankieta_1_i_2: subjective improvement in exercise capacity after cardiac rehabilitation compared to the post-MI period according to the second questionnaire (1 for yes, 0 for no) godzina_przyjecia_b_blokera_przed_testem_56_ankieta_1_i_2: time of beta-blocker administration before the test according to the second questionnaire zawal_cpxe1_followup: follow-up status of myocardial infarction after the first cardiopulmonary exercise test (1 for positive, 0 for negative) cpxe_1_cpxe1_followup: follow-up status of the first cardiopulmonary exercise test (1 for positive, 0 for negative) cpxe_2_cpxe1_followup: follow-up status of the second cardiopulmonary exercise test (1 for positive, 0 for negative) cr_k_cpxe1_followup: follow-up creatinine test result (1 for normal, 0 for abnormal) cr_ik_cpxe1_followup: follow-up creatinine kinase test result (1 for normal, 0 for abnormal) k_2x_cpxe1_followup: follow-up number of sessions per week ik_2x_cpxe1_followup: follow-up number of weeks in the program ankieta_yes_cpxe1_followup: completion status of the follow-up questionnaire (1 for completed, 0 for not completed) end_point_cpxe1_followup: status of the follow-up endpoint (1 for event, 0 for no event) all_death_cpxe1_followup: all-cause mortality during follow-up (1 for death, 0 for alive) cv_death_cpxe1_followup: cardiovascular mortality during follow-up (1 for death, 0 for alive) date_of_end_point_cpxe1_followup: date of the follow-up endpoint ozw_ihd_exacerb_cpxe1_followup: exacerbation of ischemic heart disease during follow-up (1 for yes, 0 for no) chf_cpxe1_followup: occurrence of congestive heart failure during follow-up (1 for yes, 0 for no) nie_odbiera_cpxe1_followup: patient unreachable during follow-up (1 for yes, 0 for no) brak_zgody_nie_chce_rozmawiac_cpxe1_followup: lack of consent or refusal to participate in follow-up (1 for yes, 0 for no) brak_numeru_numer_nie_istnieje_cpxe1_followup: invalid or non-existent phone number during follow-up (1 for yes, 0 for no) dolegliwosci_od_ostatniej_hospitalizacji_1_wystapily_0_nie_wystapily_cpxe1_followup: occurrence of symptoms since the last hospitalization during follow-up (1 for yes, 0 for no) jakie_cpxe1_followup: description of symptoms reported during follow-up event_neuro_udar_tia_cpxe1_followup: occurrence of neurological events during follow-up (1 for yes, 0 for no) udar_cpxe1_followup: occurrence of stroke during follow-up (1 for yes, 0 for no) tia_cpxe1_followup: occurrence of transient ischemic attack during follow-up (1 for yes, 0 for no) hosp_cpxe1_followup: occurrence of hospitalization during follow-up (1 for yes, 0 for no) nikotynizm_aktywny_cpxe1_followup: active smoking during follow-up (1 for yes, 0 for no) aktywnosc_0_3_cpxe1_followup: level of physical activity during follow-up (0-3 scale) dodatkowe_uwagi_cpxe1_followup: additional comments during follow-up end_point_final_card: final endpoint status in cardiac follow-up (1 for event, 0 for no event) combined_end_point_card_neo_death: combined endpoint status including non-cardiac causes of death in follow-up (1 for event, 0 for no event) date_endpoint_or_questionnaire: date of endpoint or questionnaire completion in follow-up bisoprolol_equ_dose: bisoprolol equivalent dose during follow-up, mg