cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.21614028.v1
title: Alternative paths to immune activation: the role of costimulatory risk genes for polygenic inflammatory disease in T helper cells

description: Count matrices for RNA-seq and ATAC-seq data, metadata, differential expression results and bias analysis results. <br> Data is from human primary CD4 T-cells that were stimulated for 24h under different costimulation conditions (with CD3+CD28, CD3+ICOS, CD3+CD6, CD3+CD27, CD3-only and mIgG2a isotype control).
DOI: 10.6084/m9.figshare.24347287.v4
title: Stable zirconium isotopic compositions of the metasomatized mantle

description: This dataset includes Zr isotopes and other compositions of basalts in this study and standards.
DOI: 10.6084/m9.figshare.25605297.v1
title: Deconvoluted scRNA-seq datasets

description: Count matrices of the human sinus node and right atrium generated with Bulk2Space.
DOI: 10.6084/m9.figshare.27871668.v1
title: Schulte et al. 2024 Ecosphere Manuscript Data

description: Dataset supporting the following manuscript: Schulte, K. D., C. J. Wilson, A. Tawril, and M. A. Jamieson. 2024. "Spatiotemporal Variability and Functional Redundancy Obscure Effects of Urbanization on Strawberry Pollinators." Ecosphere. Accepted for publication.
DOI: 10.6084/m9.figshare.5436136.v9
title: 1000 Empirical Time series

description: A diverse selection of 1000 empirical time series, along with results of an <i>hctsa</i> feature extraction, using v1.03 of <i>hctsa</i> and Matlab 2019b, computed on a linux server at Sydney University.<br>The results of the computation are in the <i>hctsa</i> file, <b>HCTSA_Empirical1000.mat</b> for use in Matlab using v1.03 of <i>hctsa</i>.<br><b><br></b>The same data is available in <b>.csv</b> format (e.g., for use with non-Matlab computing environments) for the <b>hctsa_datamatrix.csv</b> (results of feature computation), with information about rows (time series) in <b>hctsa_timeseries-info.csv</b>, information about columns (features) in <b>hctsa_features.csv</b> and the data of individual time series (each line a time series, for time series described in <b>hctsa_timeseries-info.csv</b>) is in <b>hctsa_timeseries-data.csv</b>. Note that these files were produced by running <b>&gt;&gt;OutputToCSV(HCTSA_Empirical1000.mat,true);</b> in <i>hctsa</i>.<b><br></b>The input file, <b>INP_Empirical1000.mat</b>,<b> </b>is for use with <i>hctsa</i>, and contains the time-series data and metadata for the 1000 time series. For example, massive feature extraction from these data on the user's machine, using <i>hctsa</i>, can proceed as<b>&gt;&gt; TS_Init('INP_Empirical1000.mat');</b><br>Some visualizations of the dataset are in <b>CarpetPlot.png </b>(first 1000 samples of all time series as a carpet (color) plot) and <b>150TS-250samples.png</b> (conventional time-series plots of the first 250 samples of a sample of 150 time series from the dataset). More visualizations can be performed by the user using <b>TS_PlotTimeseries</b> from the <i>hctsa</i> package.<br><br>See links in references for more comprehensive documentation for performing methodological comparison using this dataset, and on how to download and use v1.03 of <i>hctsa</i>.
DOI: 10.17632/jz42mww9cj
title: Connection between subduction seismotectonic variation and hydrothermal regime: Implications from juxtaposed slab dehydration and decarbonation below the Philippine forearc

description: The data includes the three-dimensional temperature field (degrees Celsius), water content (wt%), dehydration rate (wt%/km), rock phase change distribution, and subduction velocity field (cm/yr) of the subducting plate, as well as the coastline and volcano distribution. The data of the model region have dimensions of 800×500×400 km (length×width×depth). The geometry of the subducted plate is well constrained by Slab2.0, and the plate ages are provided by EarthByte. The temperature boundary condition agrees with the plate cooling model. The bottom of the slab and the perpendicular plane are prescribed as adiabatic and permeable, and the top surface is set to a fixed temperature (0°C) and is rigid. The data was acquired through 3-D numerical thermal modeling which was developed from originally code stag3d. An anelastic liquid approximation and the equations of conservation of mass, momentum, and energy are used in this model. Based on a three-dimensional thermomechanical model and the collect earthquake catalog from IRIS, the data of the slab thermal state, water content, and slab dehydration distribution in Vanuatu are calculated. The geophysical calculation is ensured after the subduction thermal regime reaches a steady state. The temperature field error range is ±50 degrees Celsius, and the velocity field error range is ±0.1cm/ yr. This data can be further used analyzing the geophysical field of subduction zone.
DOI: 10.17632/n5gpv3tpyn
title: Composition and resistant modulatory activities of three solvents extracts of lemongrass (Cymbopogon citratus) on methicillin-resistant Staphylococcus aureus (MRSA) determined by GC/MS and HPLC-UV analysis

description: An evaluation of the antimicrobial resistance modulatory effects of three extractable fractions of lemongrass (Cymbopogon citratus): aqueous and ethanol extracts, and lemongrass essential oil in combination with selected antibiotics ampicillin, tetracycline, streptomycin, cefloxacin and amoxicillin on methicillin-resistant Staphylococcus aureus (MRSA) was performed. Our study showed that at sub-inhibitory concentrations, lemongrass oil highly potentiated the activities of three antibiotics; amoxicillin, streptomycin and tetracycline (all antibiotics also at sub-inhibitory concentrations). The ethanol extract enhanced the activity of tetracycline and ampicillin, while the aqueous extract only increased the activity of tetracycline against MRSA. The activity of cefloxacin with the extracts was either indifferent or antagonistic. GC/MS analysis of the lemongrass oil showed the prominence of three ions: the two isomers Z (neral) and E (geranial) of citral (3,7-dimethyl-2,6-octadienal) and, the acetate of the E-isomer, geranyl acetate, which together made up 94% of the composition. HPLC-UV (λ 233 nm) analysis of the three extracts confirmed that these compounds were dominant in the lemongrass oil. They were also observed in the ethanol and water extracts but to a lesser extent. Our study confirms the antibacterial properties of the extracts especially, lemongrass oil. It also demonstrates that lemongrass oil potentiates the activities of three antibiotics against the biofilm-forming MRSA. This biocidal, anti-biofilm disruption and antibiotic potentiating abilities is mainly attributable to citral and geranyl acetate, a further evidence of lemongrass oil as a very useful source of phytochemicals, especially citral for the fight against antibiotic resistance. In this report, we freely present the raw GC/MS data of the lemongrass oil (Abaye et al. lemongrass GC/MS data 2022) and the HPLC-UV output of the three fractions. A full article has been accepted for publication in the journal Chemistry & Biodiversity (Wiley).
DOI: 10.6084/m9.figshare.26232140.v1
title: Supplementary Material for: Functional characterization of thyroid peroxidase missense variants causing thyroid dyshormonogenesis in Asian Indian population

description: Introduction: Thyroid dyshormonogenesis (TDH) is a sub-group of congenital hypothyroidism with recessive inheritance resulting from disease causing variants in thyroid hormone biosynthesis pathway genes, like DUOX2, TG, TPO, SLC5A5, SLC26A4, IYD, DUOXA2, SLC26A7 and SECISBP2. Thyroid peroxidase (TPO) is a crucial enzyme involved in thyroid hormone biosynthesis and is one of the frequently mutated genes in patients with TDH. The purpose of the study is to describe the insilico and functional characterization of novel variants in TPO gene identified in patients with thyroid dyshormonogenesis. 
Methods: We performed exome sequencing in Indian patients with TDH. In the current study, we describe the results of patients with TPO gene mutations. Exome sequencing results were further analysed by sanger sequencing, computational studies and invitro functional studies such as immunofluorescence and enzyme assay.
Results: We identified nine biallelic disease-causing variants in the TPO gene in twelve patients from nine unrelated Indian families. Eight of the nine variants were novel. No recurrent variants were identified. Computational analysis of six missense variants showed that these amino acid substitutions caused changes in non-covalent interactions with the adjacent residues that may affect the TPO protein structure and function. In-vitro experimental data using immunofluorescence assay showed that these variants did not affect the plasma membrane localization of the TPO protein but caused significant loss of TPO enzymatic activity compared to wild type. 
Conclusion: Our study revealed multiple novel pathogenic variants in TPO gene in Indian patients, thereby expanding the genotype spectrum. Functional studies helped us to reveal the pathogenicity of the missense variants.
DOI: 10.17632/7k7z4sx275
title: Shear Links Database – Hysteretic Performance from Numerical Simulations

description: This dataset presents the hysteretic performance of shear links under cyclic loading, obtained through high-fidelity numerical simulations using ANSYS Workbench 2023 R1. The research hypothesis posits that geometric parameters and material nonlinearities significantly influence the cyclic performance of shear links, which are critical components in earthquake-resistant structures. The numerical results provide a comprehensive assessment of the strength, buckling, and shear response of shear links, offering insights into their cyclic behavior. The dataset includes geometric properties, material characteristics, and key response parameters such as yield shear force, plastic shear capacity, stiffness, and shear rotation-dependent shear forces at different rotation angles. The numerical simulations employed a quasi-static, deformation-controlled cyclic loading protocol following AISC 341-10 requirements. Material and geometric nonlinearities were fully incorporated in the analysis to ensure realistic representation of shear link behavior under cyclic demands. A Chaboche nonlinear kinematic hardening model was utilized to capture the cyclic material response accurately. All simulations were performed using the finite element method with SHELL181 elements, ensuring accurate representation of plate out-of-plane deformation. The finite element mesh was refined to include 12 web height divisions for all specimens, providing sufficient resolution to capture buckling and yielding patterns. The results confirm that shear link performance is highly dependent on web slenderness, flange dimensions, and stiffener spacing. Yielding predominantly occurs in the web, with flange restraint influencing stability and delaying buckling. This dataset supports structural engineers and researchers in developing new shear link configurations and refining seismic design provisions. The numerical results can serve as input for machine-learning applications, parametric studies, or comparative analyses with experimental data. Each column in the dataset is clearly labeled, with a metadata file providing detailed descriptions to facilitate data interpretation and application.
DOI: 10.17632/k63trwdfmk
title: Cross-border loans of the 61 biggest European banks

description: The database contains cross-border exposures (as a % of total exposures) to individual countries for the 61 largest European banks over the years 2010-2015. Getting a complete overview of the cross-border positions of European banks is challenging, as there are no regular reporting standards for banks’ foreign exposures split by country. One option is to focus on banks’ foreign subsidiaries. This may however lead to a significant underestimation of a bank’s foreign activities, especially since European banks conduct around half of their foreign activities vis branches. With this dataset we aim to provide a more complete picture of banks' cross-border exposures and collected the data ourselves from public sources. We collected the data for the 61 largest European banks. These banks together represent around two-third of total European banking assets. The 61 banks together invest in 138 different countries (the countries are presented by their ISO2 codes). Data on cross-border exposures are primarily obtained from annual reports, and, when needed, supplemented with data stemming from the public EBA stress tests conducted in 2011 and 2013, and CRD IV country-by-country reporting.Due to the absence of a standard reporting format some assumptions and simplifications had to be made. First of all, the majority of banks report their foreign exposures in loans or assets, but some banks use the net income as the reporting unit. As we are especially interested in banks’ credit exposures to other countries, we had an order of preference for exposures reported in i) loans; ii) assets; and iii) net income. Second, we aimed for cross-border exposures at the country level as for our analysis we link home and host country characteristics. However, sometimes only information on banks’ exposures to a group of countries (e.g. Western Europe) or continents (e.g. Asia) was available. In those cases, we simply reported the exposures to groups of countries or continents (see columns EN-EX in the database). Third, the data collection resulted in an almost complete overview of the foreign exposures of the 61 European banks. For only a small portion of foreign exposures (3.6% of the total foreign exposures or 1.1% of the total assets) we do not know to which region or country these belong . This is the case when banks report their remaining foreign exposures as “other” without mentioning the countries belonging to this group (here we used "in-sample" estimation). Note that it also happens that a bank reports about its cross-border exposures quite granular for one year (i.e. exposures to multipe individual countries), and the subsequent year only reports the total exposures to "rest of europe" and "america". In those cases information from the years with granular information is used to make assumptions about the other years' cross-border exposures.
DOI: 10.17632/s76tjsb4gb
title: Production Complementarity and Information Transmission Across Industries

description: Replication package (codes and pseudo data) for “Production Complementarity and Information Transmission Across Industries”
DOI: 10.17632/s9f5ggxrfd
title: Data for: A Hybrid Energy-Aware Virtual Machine Placement Algorithm in Cloud Environment

description: This Folder contains the Matlab code Implementation for the proposed IGA-POP algorithm for virtual machine placement in cloud environments.
DOI: 10.6084/m9.figshare.20303979.v1
title: MproMutationDynamics_GISAID_Acknowledgment_Table

description: The Acknowledgment Table includes Accession Numbers and the origin of genome sequences available at GISAID.
DOI: 10.6084/m9.figshare.25826065.v1
title: Eddy Covariance Data for an Alpine Wetland in Shenzha (2017-2021)

description: Eddy Covariance Data for an Alpine Wetland in Shenzha from 2017 to 2021.
DOI: 10.6084/m9.figshare.7171778.v1
title: Supplementary Material for: Drug Lag for Inflammatory Bowel Disease Treatments in the East and West

description: <b><i>Background:</i></b> Inflammatory bowel disease (IBD), though historically common in the West, is now increasingly prevalent in industrializing countries. A simultaneous dramatic increase in IBD drug options has enabled most patients to achieve remission. Nevertheless, worldwide disparities in the approval of IBD drugs, or “drug lag”, remain problematic. <b><i>Summary:</i></b> Drug lag for major IBD drugs before March 31, 2018 (12 for Crohn’s disease [CD] and 13 for ulcerative colitis [UC]) was compared between that of the United States (US), European Union (EU), and Asia (Japan, China, South Korea, Taiwan, and the Philippines) to assess current trends. In the US, unapproved IBD drugs accounted for 16.7% (2/12) for CD and 23.1% (3/13) for UC; approval lag was 3.8 (0–80.5) months for CD and 3.6 (0–88) months for UC. In the EU, unapproved drugs accounted for 16.7% (2/12) for CD and 15.4% (2/13) for UC; approval lag was 0.03 (0–13.9) months for CD and 0 (0–13.9) months for UC. This demonstrates the short drug lag in both regions, although one drug developed in a joint US/EU clinical trial had around a 350-day approval lag. In Asia, the proportion of unapproved IBD drugs was the lowest in Japan at 33.3% (4/12) for CD and 23.1% (3/13) for UC; South Korea had the shortest lag for CD at 13.2 (0–133.1) months and the Philippines had the shortest lag for UC at 9.9 (0.6–176.2) months, but these countries still had longer lag periods than the West. However, a proportion of unapproved drugs and approval lag has decreased considerably in Asia since the start of the biologics era. <b><i>Key Messages:</i></b> Despite the recent shortening drug lag between different countries and regions, this study shows that disparities persist. With globalization, eliminating these disparate drug lags is necessary to manage IBD and may require efforts toward international adoption of a more standardized approval process.
DOI: 10.17632/nshyw24427
title: The Ultimate Laboratory Guide: Determining Vitamin C levels through Iodine Titration

description: Ascorbic acid, also known as vitamin C, is a crucial water-soluble vitamin that plays a vital role incollagen production, neurotransmitter production, and antioxidant activity. It is essential for determiningfood's nutritional value and understanding potential health benefits. Iodine titration is a widely used methodfor determining vitamin C content, as it relies on the ascorbic acid and iodine oxidation-reduction reaction inan acidic environment. Iodine is reduced to iodide ions during the reaction, resulting in the formation ofdehydroascorbic acid and iodide ions. The color change is primarily due to the formation of a complex between iodine and starch, which serves as an indicator in the titration. In the presence of iodine, starchforms a deep blue-black complex, and the disappearance of the blue-black color at the end of the titrationindicates the completion of the reaction between Vitamin C and iodine. This method is useful for routineanalysis in educational and industrial contexts due to its simplicity, precision, and cost-effectiveness. The aimof this experiment is to measure the amount of ascorbic acid in a sample using iodine titration, providingcrucial information about the nutritional makeup of the material beingstudied.
DOI: 10.6084/m9.figshare.1433996.v1
title: Altered Resting-state Brain Activity and Connectivity in Depressed Parkinson’s Disease

description: ALFF file is all subjects' ALLF map, MCC-FC file is all subjects' MCC-FC map.
DOI: 10.6084/m9.figshare.16550451.v1
title: Ficha técnica serie Élite

description: Ficha técnica de la serie de televisión Élite
DOI: 10.6084/m9.figshare.21191209.v1
title: Trend Surface Analysis

description: Taxi OD flow data in Beijing broad CBD area with 15 workdays from October 8th to October 29th, 2014 (the data on October 16th were missing); The code of Trend surface Analysis of flow
DOI: 10.17632/5rchtsps3z
title: Genome-wide kinetic properties of transcriptional bursting in mouse embryonic stem cells

description: This file includes raw data used to generate Figures 1, 2, 3, 4, 5 and 6, and Figure S1, S2, S3, S4, S5 and S6.
DOI: 10.17632/dtk9c2m5ct
title: Research data for article: Limited microbial degradation of elevated concentrations of dissolved organic carbon in the deep ocean (DOI:10.1002/lno.70000)

description: This data are published in an article entitled "Limited microbial degradation of elevated concentrations of dissolved organic carbon in the deep ocean" in Limnology and Oceanography (DOI:10.1002/lno.70000). Full description and interpretation of this dataset can be found in the above article.
DOI: 10.17632/m3zjf8z286
title: Bubble Image Database

description: Collection of the Bubble images: Bubbles were generated inside the column and bubble images were taken with a bubble viewer. All images were manually classified into five classes according to the gas dispersion states. # Class 1: Fine bubbles fully covering the viewing window # Class 2: Fine bubbles partially covering the viewing window # Class 3: Co-exit of coarse and fine bubbles # Class 4: Only coarse bubbles # Class 5: No bubbles Training set contains in total 5184 original images and 25920 augumented images. Test set contains 582 original images.
DOI: 10.4121/16713340.v1
title: Delft3d model and script for damage curves development.

description: Delft3d model and script for damage curves development in the area of La Rochelle and Ille du Re for storm Xynthia (2010). Dataset for the paper accepted for publication in NHESS<br><br><br>
DOI: 10.6084/m9.figshare.11316731.v1
title: MECP2 ExAC genetic variant data in CSV

description: MECP2 genetic variant data from ExAC in CSV format.<br>FAIR machine-readable metadata is available at:http://purl.org/biosemantics-lumc/rettbase/fdp<br>
DOI: 10.6084/m9.figshare.20026575.v1
title: Comparison of tooth movement and biological response resulting from different force magnitudes combined with osteoperforation in rabbits

description: Abstract Objective To compare tooth movement rate and histological responses with three different force magnitude designs under osteoperforation in rabbit models. Methodology 48 rabbits were divided into three groups: Group A, Group B, and Group C, with traction force of 50 g, 100 g, 150 g, respectively. Osteoperforation was performed at the mesial of the right mandibular first premolar, the left side was not affected. One mini-screw was inserted into bones between two central incisors. Coil springs were fixed to the first premolars and the mini-screw. Tooth movement distance was calculated, and immunohistochemical staining of PCNA, OCN, VEGF, and TGF-β1 was analyzed. Results The tooth movement distance on the surgical side was larger than the control side in all groups (P&lt;0.01). No significant intergroup difference was observed for the surgical side in tooth movement distance among the three groups (P&gt;0.05). For the control side, tooth movement distance in Group A was significantly smaller than Groups B and C (P&lt;0.001); no significant difference in tooth movement distance between Group B and Group C was observed (P&gt;0.05). On the tension area of the moving premolar, labeling of PCNA, OCN, VEGF and TGF-β1 were confirmed in alveolar bone and periodontal ligament in all groups. PCNA, OCN, VEGF and TGF-β1 on the surgical side was larger than the control side in all groups (P&lt;0.001). Conclusion Osteoperforation could accelerate orthodontic tooth movement rate in rabbits. Fast osteoperforation-assisted tooth movement in rabbits was achieve with light 50 g traction.
DOI: 10.6084/m9.figshare.25471537.v1
title: Raw data for Chang'an CEE paper

description: Raw data of Figures and supplementary figures for the paper entitled Release and re-enrichment of invisible gold in arsenian pyrite promoted by coupled dissolution-reprecipitation reactions
DOI: 10.17632/b5zmgghxyj
title: Data on the experimental characterization of a mobile wick solar still with external condenser tested under the climatic conditions of Rennes, France.

description: The experiment collected data on the temperature evolution of the solar still's elements, as well as the external ambient environment, relative humidities of the evaporator tank and ambient environment, global sunshine, and hourly production of consumable water. The final measurement was the amount of consumable water produced by the solar still, which was measured hourly using a graduated container for volume. The data measured have been used to calculate energy and exergy yields.
DOI: 10.6084/m9.figshare.29168225.v1
title: A ladybird with red spots on a black body

description: A test piece of content for a test project