cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.13900673.v1
title: Genetic polymorphisms of 44 Y chromosomal genetic markers in the Inner Mongolia Han population and its genetic relationship analysis with other reference populations

description: Y chromosomal genetic markers in the non-recombining region are commonly used for human evolution research, familial searching, and forensic male differentiation since they strictly follow paternal inheritance. Y chromosomal short tandem repeats (Y-STRs) possess extraordinarily advantages in forensic applications because of their high polymorphisms and special genetic pattern. Here, we assessed the genetic diversities of 41 Y-STRs and three Y chromosomal insertion/deletion (Y-InDels) loci in the Chinese Inner Mongolia Han population; besides, genetic differentiation analyses among the studied Han population and other previously reported populations were conducted based on 27 same Y-STRs. Totally, 425 alleles were observed in 324 Inner Mongolia Han individuals for these Y-markers. Gene diversities of these Y-markers distributed from 0.0306 to 0.9634. The haplotype diversity and discriminatory capacity of these Y-markers in the Inner Mongolia Han population were 0.9999 and 0.98457, respectively. Haplotype resolution comparisons of different Y-marker groups in the studied Han population revealed that higher haplotype resolution could be achieved for these 44 Y-markers. Population genetic analyses of the Inner Mongolia Han population and other reference populations demonstrated that the studied Han population had relatively closer genetic affinities with Northern Han Chinese populations than Southern Han and other minority groups. To sum up, these 44 Y-markers can be utilized as a valuable tool for male differentiation in the Inner Mongolia Han population.
DOI: 10.6084/m9.figshare.12852108
title: The inverse-probability-of-censoring weighting (IPCW) adjusted win ratio statistic: an unbiased estimator in the presence of independent censoring

description: The win ratio method has received much attention in methodological research, ad hoc analyses, and designs of prospective studies. As the primary analysis, it supported the approval of tafamidis for the treatment of cardiomyopathy to reduce cardiovascular mortality and cardiovascular-related hospitalization. However, its dependence on censoring is a potential shortcoming. In this article, we propose the inverse-probability-of-censoring weighting (IPCW) adjusted win ratio statistic (i.e., the IPCW-adjusted win ratio statistic) to overcome censoring issues. We consider independent censoring, common censoring across endpoints, and right censoring. We develop an asymptotic variance estimator for the logarithm of the IPCW-adjusted win ratio statistic and evaluate it via simulation. Our simulation studies show that, as the amount of censoring increases, the unadjusted win proportions may decrease greatly. Consequently, the bias of the unadjusted win ratio estimate may increase greatly, producing either an overestimate or an underestimate. We demonstrate theoretically and through simulation that the IPCW-adjusted win ratio statistic gives an unbiased estimate of treatment effect.
DOI: 10.6084/m9.figshare.12852108.v1
title: The inverse-probability-of-censoring weighting (IPCW) adjusted win ratio statistic: an unbiased estimator in the presence of independent censoring

description: The win ratio method has received much attention in methodological research, ad hoc analyses, and designs of prospective studies. As the primary analysis, it supported the approval of tafamidis for the treatment of cardiomyopathy to reduce cardiovascular mortality and cardiovascular-related hospitalization. However, its dependence on censoring is a potential shortcoming. In this article, we propose the inverse-probability-of-censoring weighting (IPCW) adjusted win ratio statistic (i.e., the IPCW-adjusted win ratio statistic) to overcome censoring issues. We consider independent censoring, common censoring across endpoints, and right censoring. We develop an asymptotic variance estimator for the logarithm of the IPCW-adjusted win ratio statistic and evaluate it via simulation. Our simulation studies show that, as the amount of censoring increases, the unadjusted win proportions may decrease greatly. Consequently, the bias of the unadjusted win ratio estimate may increase greatly, producing either an overestimate or an underestimate. We demonstrate theoretically and through simulation that the IPCW-adjusted win ratio statistic gives an unbiased estimate of treatment effect.
DOI: 10.5519/qd.55s84jxr
title: Query on the Natural History Museum Data Portal (data.nhm.ac.uk) (19 records)
DOI: 10.6084/m9.figshare.12852228
title: An organic–inorganic hybrid nanoscale phosphotungstate with reactive oxygen species catalytic ability

description: An organic-inorganic hybrid polyoxometalate (POM) based on bi-nuclear copper complexes and Dawson-type phosphotungstate (POT) [CuL(H<sub>2</sub>O)][CuL]<sub>2</sub>[P<sub>2</sub>W<sub>18</sub>O<sub>62</sub>]·3H<sub>2</sub>O (abbreviated as CPW) (L = 2-(1<i>H</i>-pyrazol-3-yl)pyridine) was synthesized and structurally characterized by IR spectrum, and single-crystal X-ray diffraction. Structural analysis indicated that CPW is nanoscale molecule and extends into a two-dimensional layer, in which three bi-nuclear copper complexes are substituted at different sites of Dawson-type POT and joined adjacent POT fragments together. Notably, CPW can efficiently catalyze the production of reactive oxygen species.
DOI: 10.6084/m9.figshare.12852228.v1
title: An organic–inorganic hybrid nanoscale phosphotungstate with reactive oxygen species catalytic ability

description: An organic-inorganic hybrid polyoxometalate (POM) based on bi-nuclear copper complexes and Dawson-type phosphotungstate (POT) [CuL(H<sub>2</sub>O)][CuL]<sub>2</sub>[P<sub>2</sub>W<sub>18</sub>O<sub>62</sub>]·3H<sub>2</sub>O (abbreviated as CPW) (L = 2-(1<i>H</i>-pyrazol-3-yl)pyridine) was synthesized and structurally characterized by IR spectrum, and single-crystal X-ray diffraction. Structural analysis indicated that CPW is nanoscale molecule and extends into a two-dimensional layer, in which three bi-nuclear copper complexes are substituted at different sites of Dawson-type POT and joined adjacent POT fragments together. Notably, CPW can efficiently catalyze the production of reactive oxygen species.
DOI: 10.6084/m9.figshare.12852231
title: Two mixed ligand Co(II)-coordination polymers: treatment ability on skin necrosis after fracture and internal fixation by reducing MCSF and TNF-α

description: Two Co(II)-containing coordination polymers, {Co(TDC)(TPB)<sub>0.5</sub>·H<sub>2</sub>O}<sub>n</sub> (<b>1</b>) and {[Co<sub>2</sub>(2,6-NDC)<sub>2</sub>(TPB)]·MeCN·3H<sub>2</sub>O}<sub>n</sub> (<b>2</b>) (TPB = 1,2,4,5-tetra(4-pyridyl)benzene, H<sub>2</sub>TDC = 2,5-thiophenedicarboxylic acid, 2,6-H<sub>2</sub>NDC = 2,6-naphthalic acid), have been synthesized by a semi-rigid tetrapyridine ligand and auxiliary dicarboxylic ligands. The treatment ability of the compounds on skin necrosis after fracture was assessed and the related mechanism was discussed. First of all, the enzyme-linked immune sorbent assay (ELISA) detection kit was used in this research to detect the content level of the Recombinant Human Macrophage Colony stimulating Factor (MCSF) and Tumor Necrosis Factor-α (TNF-α) after compound treatment. Next, the real time quantitative polymerase chain reaction (RT-PCR) was conducted for the MMP2 and TIMP1 relative expression levels measurement.
DOI: 10.6084/m9.figshare.12852231.v1
title: Two mixed ligand Co(II)-coordination polymers: treatment ability on skin necrosis after fracture and internal fixation by reducing MCSF and TNF-α

description: Two Co(II)-containing coordination polymers, {Co(TDC)(TPB)<sub>0.5</sub>·H<sub>2</sub>O}<sub>n</sub> (<b>1</b>) and {[Co<sub>2</sub>(2,6-NDC)<sub>2</sub>(TPB)]·MeCN·3H<sub>2</sub>O}<sub>n</sub> (<b>2</b>) (TPB = 1,2,4,5-tetra(4-pyridyl)benzene, H<sub>2</sub>TDC = 2,5-thiophenedicarboxylic acid, 2,6-H<sub>2</sub>NDC = 2,6-naphthalic acid), have been synthesized by a semi-rigid tetrapyridine ligand and auxiliary dicarboxylic ligands. The treatment ability of the compounds on skin necrosis after fracture was assessed and the related mechanism was discussed. First of all, the enzyme-linked immune sorbent assay (ELISA) detection kit was used in this research to detect the content level of the Recombinant Human Macrophage Colony stimulating Factor (MCSF) and Tumor Necrosis Factor-α (TNF-α) after compound treatment. Next, the real time quantitative polymerase chain reaction (RT-PCR) was conducted for the MMP2 and TIMP1 relative expression levels measurement.
DOI: 10.6084/m9.figshare.12852234
title: Heterometallic La(III)-Co(II) coordination polymers: treatment activity on diabetic foot by reducing the TLR-4–NF-κB signaling pathway activation in the plantar tissue

description: Two new heterometallic coordination polymers (CPs) formulated as [LaCoCl(2,5-pydc)<sub>2</sub>(H<sub>2</sub>O)<sub>4</sub>]Cl (<b>1</b>, 2,5-H<sub>2</sub>pydc =  pyridine-2,5-dicarboxylic acid) and [LaCoCl<sub>2</sub>(5,5 =  pyridin<sub>3</sub>)(H<sub>2</sub>O)] (<b>2</b>, 5,5′-H<sub>2</sub>bpdc = 2,2ridine-2,5-dicar-dicarboxylic acid) have been solvothermally synthesized on the basis of the coordination between rare earth/transition metal ions and pyridinedicarboxylic acids. Their treatment activity on diabetic foot (DF) was evaluated in biological research. First of all, the content of the inflammatory cytokines in the plantar tissue was measured with the ELISA detection kit. Next, the real-time RT-PCR was performed for the measurement of the TLR-4–NF-κB signaling pathway activation.
DOI: 10.6084/m9.figshare.12852234.v1
title: Heterometallic La(III)-Co(II) coordination polymers: treatment activity on diabetic foot by reducing the TLR-4–NF-κB signaling pathway activation in the plantar tissue

description: Two new heterometallic coordination polymers (CPs) formulated as [LaCoCl(2,5-pydc)<sub>2</sub>(H<sub>2</sub>O)<sub>4</sub>]Cl (<b>1</b>, 2,5-H<sub>2</sub>pydc =  pyridine-2,5-dicarboxylic acid) and [LaCoCl<sub>2</sub>(5,5 =  pyridin<sub>3</sub>)(H<sub>2</sub>O)] (<b>2</b>, 5,5′-H<sub>2</sub>bpdc = 2,2ridine-2,5-dicar-dicarboxylic acid) have been solvothermally synthesized on the basis of the coordination between rare earth/transition metal ions and pyridinedicarboxylic acids. Their treatment activity on diabetic foot (DF) was evaluated in biological research. First of all, the content of the inflammatory cytokines in the plantar tissue was measured with the ELISA detection kit. Next, the real-time RT-PCR was performed for the measurement of the TLR-4–NF-κB signaling pathway activation.
DOI: 10.6084/m9.figshare.12852237
title: A new 3D zinc (II)-coordination polymer: treatment activity on lymphoma combined with doxorubicin via regulating apoptotic genes expression

description: A new zinc (II) coordination polymer (CP) with the chemical formula of [Zn<sub>3</sub>(L)<sub>2</sub>(mtba)<sub>2</sub>]<sub>n</sub> (<b>1</b>) (L = 1,4-bis(benzimidazol-1-yl)-2-butene, H<sub>3</sub>mtb= 5-methoxybenzene-1,2,3-tricarboxylic acid) was hydrothermally synthesized by reaction of ZnSO<sub>4 </sub>· 7H<sub>2</sub>O with the 1,2,3-benzenetricarboxylic acid in the presence of the 1,4-bis(benzimidazol-1-yl)-2-butene ligand. Its anti-cancer activity on the lymphoma, bombinated with anthracyclines, doxorubicin was evaluated in this research. First, the cell apoptosis detection kit was used to detect the percentages of the apoptotic lymphoma cells after compound treatment. Next, the real-time RT-PCR was performed for the evaluation of the <i>p53</i> and <i>bcl-2</i> genes relative expression in the lymphoma cells. Results from molecular docking simulation have shown that the biological activity are directly related to the carbonyl functional group.
DOI: 10.6084/m9.figshare.12852237.v1
title: A new 3D zinc (II)-coordination polymer: treatment activity on lymphoma combined with doxorubicin via regulating apoptotic genes expression

description: A new zinc (II) coordination polymer (CP) with the chemical formula of [Zn<sub>3</sub>(L)<sub>2</sub>(mtba)<sub>2</sub>]<sub>n</sub> (<b>1</b>) (L = 1,4-bis(benzimidazol-1-yl)-2-butene, H<sub>3</sub>mtb= 5-methoxybenzene-1,2,3-tricarboxylic acid) was hydrothermally synthesized by reaction of ZnSO<sub>4 </sub>· 7H<sub>2</sub>O with the 1,2,3-benzenetricarboxylic acid in the presence of the 1,4-bis(benzimidazol-1-yl)-2-butene ligand. Its anti-cancer activity on the lymphoma, bombinated with anthracyclines, doxorubicin was evaluated in this research. First, the cell apoptosis detection kit was used to detect the percentages of the apoptotic lymphoma cells after compound treatment. Next, the real-time RT-PCR was performed for the evaluation of the <i>p53</i> and <i>bcl-2</i> genes relative expression in the lymphoma cells. Results from molecular docking simulation have shown that the biological activity are directly related to the carbonyl functional group.
DOI: 10.6084/m9.figshare.12852240
title: A Cu(II) complex: treatment activity on intracerebral hemorrhage via inhibiting inflammatory response in vascular endothelial cells

description: A new Cu(II)-based coordination polymer (CP), {[Cu(bpa)(1,3-BDC)(H<sub>2</sub>O)](DMF)<sub>n</sub>}<sub>n</sub> (<b>1</b>), (DMF = dimethylformamide) was synthesized by reaction of the Cu(NO<sub>3</sub>)<sub>2</sub>·3H<sub>2</sub>O with the 3,6-bis(benzimidazol-1-yl)pyridazine (bpa) presence of the isophthalic acid (1,3-H<sub>2</sub>BDC). Its intracerebral hemorrhage (ICH) protective treatment was assessed and the related mechanism was explored as well. The real time RT-PCR was used to detect the relative expression levels of the ROS related genes, which reflected the intracellular ROS levels in the vascular endothelial cells. Next, the western blotting assay was performed and the inflammatory responses levels in the vascular endothelial cells were evaluated.
DOI: 10.6084/m9.figshare.12852240.v1
title: A Cu(II) complex: treatment activity on intracerebral hemorrhage via inhibiting inflammatory response in vascular endothelial cells

description: A new Cu(II)-based coordination polymer (CP), {[Cu(bpa)(1,3-BDC)(H<sub>2</sub>O)](DMF)<sub>n</sub>}<sub>n</sub> (<b>1</b>), (DMF = dimethylformamide) was synthesized by reaction of the Cu(NO<sub>3</sub>)<sub>2</sub>·3H<sub>2</sub>O with the 3,6-bis(benzimidazol-1-yl)pyridazine (bpa) presence of the isophthalic acid (1,3-H<sub>2</sub>BDC). Its intracerebral hemorrhage (ICH) protective treatment was assessed and the related mechanism was explored as well. The real time RT-PCR was used to detect the relative expression levels of the ROS related genes, which reflected the intracellular ROS levels in the vascular endothelial cells. Next, the western blotting assay was performed and the inflammatory responses levels in the vascular endothelial cells were evaluated.
DOI: 10.6084/m9.figshare.12852249
title: Zn(II) and Co(II)-based coordination polymers: anesthesia effect by regulating animal blood pressure in hip replacement operation

description: Two new transition coordination polymers (CPs) with the chemical formula of {[Zn<sub>4</sub>(dip)<sub>4</sub>(H<sub>2</sub>O)<sub>2</sub>(4-ppbp)<sub>2</sub>]<b>·</b>12H<sub>2</sub>O}<i><sub>n</sub></i> (<b>1</b>, H<sub>2</sub>dpa = diphenic acid, 4-ppbp = (propane-1,3-diylbis(piperazine-4,1-diyl))bis(pyridin-4-ylmethanone)) and [Co(dipH)<sub>2</sub>(bdin)]<i><sub>n</sub></i> (<b>2</b>, bdin = N,N-(butane-1,3-diyl)diisonicotinamide) have been successfully prepared by reaction of the corresponding metal salts with the H<sub>2</sub>dpa ligand in the presence of different flexible dipyridylamide ligands. Its treatment activity combined with epidural anesthesia for hip replacement was evaluated. First, the hip replacement operation was carried on experimental mice, followed by the compound given combined with epidural anesthesia. The animal survival rate as well as the rate of anesthesia was recorded and analyzed. In addition to this, the blood pressure level of the mice was also determined throughout the procession of the hip replacement operation.
DOI: 10.6084/m9.figshare.12852249.v1
title: Zn(II) and Co(II)-based coordination polymers: anesthesia effect by regulating animal blood pressure in hip replacement operation

description: Two new transition coordination polymers (CPs) with the chemical formula of {[Zn<sub>4</sub>(dip)<sub>4</sub>(H<sub>2</sub>O)<sub>2</sub>(4-ppbp)<sub>2</sub>]<b>·</b>12H<sub>2</sub>O}<i><sub>n</sub></i> (<b>1</b>, H<sub>2</sub>dpa = diphenic acid, 4-ppbp = (propane-1,3-diylbis(piperazine-4,1-diyl))bis(pyridin-4-ylmethanone)) and [Co(dipH)<sub>2</sub>(bdin)]<i><sub>n</sub></i> (<b>2</b>, bdin = N,N-(butane-1,3-diyl)diisonicotinamide) have been successfully prepared by reaction of the corresponding metal salts with the H<sub>2</sub>dpa ligand in the presence of different flexible dipyridylamide ligands. Its treatment activity combined with epidural anesthesia for hip replacement was evaluated. First, the hip replacement operation was carried on experimental mice, followed by the compound given combined with epidural anesthesia. The animal survival rate as well as the rate of anesthesia was recorded and analyzed. In addition to this, the blood pressure level of the mice was also determined throughout the procession of the hip replacement operation.
DOI: 10.6084/m9.figshare.12852252
title: A new mixed-ligand Co(II) coordination polymer: treatment activity on ulcerative colitis by inhibiting the JAK2/STAT3 signaling pathway in the colonic epithelial cells

description: In the current study, a novel mixed-ligand coordination polymer, {[Co(L)(dpe)]·(ClO<sub>4</sub>)} (<b>1</b>) (H<sub>2</sub>LCl = 3-carboxy-1-(3-carboxybenzyl)pyridin-1-ium, dpe = (E)-1,2-di(pyridin-4-yl)ethene), was synthesized under hydrothermal conditions by a zwitterionic organic ligand and fully characterized by the single crystal X-ray diffraction, powder X-ray diffraction, elemental analysis along with the FT-IR. Furthermore, the treatment activity of the compound on the ulcerative colitis was evaluated and the related mechanism was explored. First, the level of the tumor necrosis factor (TNF)-α and superoxide dismutase (SOD) released by the colon tissue into the plasma was measured with enzyme-linked immunosorbent assay (ELISA) detection kit. In addition to this, the activation level of the JAK2/STAT3 signaling pathway in the colonic epithelial cells was also determined with western blot. With the help of molecular docking simulation, the potential interacting gestures between the complex and the protein have been revealed.
DOI: 10.6084/m9.figshare.12852252.v1
title: A new mixed-ligand Co(II) coordination polymer: treatment activity on ulcerative colitis by inhibiting the JAK2/STAT3 signaling pathway in the colonic epithelial cells

description: In the current study, a novel mixed-ligand coordination polymer, {[Co(L)(dpe)]·(ClO<sub>4</sub>)} (<b>1</b>) (H<sub>2</sub>LCl = 3-carboxy-1-(3-carboxybenzyl)pyridin-1-ium, dpe = (E)-1,2-di(pyridin-4-yl)ethene), was synthesized under hydrothermal conditions by a zwitterionic organic ligand and fully characterized by the single crystal X-ray diffraction, powder X-ray diffraction, elemental analysis along with the FT-IR. Furthermore, the treatment activity of the compound on the ulcerative colitis was evaluated and the related mechanism was explored. First, the level of the tumor necrosis factor (TNF)-α and superoxide dismutase (SOD) released by the colon tissue into the plasma was measured with enzyme-linked immunosorbent assay (ELISA) detection kit. In addition to this, the activation level of the JAK2/STAT3 signaling pathway in the colonic epithelial cells was also determined with western blot. With the help of molecular docking simulation, the potential interacting gestures between the complex and the protein have been revealed.
DOI: 10.6084/m9.figshare.6560798
title: Data File 1.xls

description: The underlying values of figure 7.
DOI: 10.6084/m9.figshare.6560798.v1
title: Data File 1.xls

description: The underlying values of figure 7.
DOI: 10.6084/m9.figshare.12852258
title: A molybdenum Schiff base complex: repairing activity on orthodontics-related root absorption by reducing the TNF-α releasing

description: The reaction between [MoO<sub>2</sub>(acac)<sub>2</sub>] and an ONO type Schiff-base ligand (L=(E)-4-bromo-2-(((2-hydroxyphenyl)imino)methyl)phenol) resulted a new oligomer molybdenum complex ([MoO<sub>2</sub>(L)]<sub>n</sub>). The oligomer complex was characterized by elemental analysis and FT-IR. The promotion ability of the compound on the osteoblast was measured with Cell Counting Kit-8 assay. The ELISA detection was performed to detect the TNF-α content released by the osteoblast. The activity of the complex to the protein is estimated and investigated by performing the molecular docking simulation.
DOI: 10.6084/m9.figshare.12852258.v1
title: A molybdenum Schiff base complex: repairing activity on orthodontics-related root absorption by reducing the TNF-α releasing

description: The reaction between [MoO<sub>2</sub>(acac)<sub>2</sub>] and an ONO type Schiff-base ligand (L=(E)-4-bromo-2-(((2-hydroxyphenyl)imino)methyl)phenol) resulted a new oligomer molybdenum complex ([MoO<sub>2</sub>(L)]<sub>n</sub>). The oligomer complex was characterized by elemental analysis and FT-IR. The promotion ability of the compound on the osteoblast was measured with Cell Counting Kit-8 assay. The ELISA detection was performed to detect the TNF-α content released by the osteoblast. The activity of the complex to the protein is estimated and investigated by performing the molecular docking simulation.
DOI: 10.6084/m9.figshare.6560816
title: Data File 2.xls

description: The underlying values of figure 9.
DOI: 10.6084/m9.figshare.6560822
title: Data File 3.xls

description: The underlying values of figure 10.
DOI: 10.6084/m9.figshare.6560822.v1
title: Data File 3.xls

description: The underlying values of figure 10.
DOI: 10.6084/m9.figshare.12852294
title: A simple and improved score confidence interval for a single proportion

description: Confidence interval (CI) for a proportion has been a topic discussed repeatedly in the literature because of its omnipresence in applications. A wide variety of CIs have been proposed since the Wald CI for a proportion performs quite poorly. Among them, the Wilson score interval is widely recommended. However, the Wilson score method suffers from the so-called “downward spikes” when the proportion is close to 0 or 1. Except for the exact methods which ensure the coverage probability be at least the nominal size, the performances of existing proposed methods are similar to the Wilson score CI or its slightly improved version at the cost of increased interval width or computational complexity. In this study, we propose a simple CI which has very good performance in the coverage probability, confidence width, and the location. Especially when the proportion is &lt;20% or &gt;80% the CI proposed has a shorter confidence width than the Wilson score method. In combination our new method with the Newcombe’s hybrid way to construct CI for the difference of two independent proportions, we also get a better CI.