DOI: 10.5061/dryad.6djh9w17n
title: 3D modeling and 4D flow data of total cavopulmonary connection (TCPC) vs. convergent cavopulmonary connection (CCPC)

description: This study conducts a comprehensive evaluation focused on assessing the
 feasibility and validation of patient-specific convergent cavopulmonary
 connection (CCPC) grafts for individuals with congenital heart defects in
 comparison with the performance of total cavopulmonary connection (TCPC)
 grafts. The datasets incorporated in this submission constitute crucial
 information enabling comprehension of our methodology and replication of
 our experiments using a mock circulatory flow loop. These datasets
 encompass 3D models, flow rates, basic demographic information, and 4D
 Flow DICOMs of 11 TCPC models. Additionally, raw CSV measurements from a
 4D Flow software for both CCPC and TCPC grafts have been included. By
 means of the development and analysis of these datasets, we have
 effectively demonstrated the non-inferiority of the CCPC configuration
 compared to the TCPC design. The CCPC modifications to the Fontan design
 did not incur additional hemodynamic costs and provided improvements in
 hepatic flow distribution. Therefore, it validates the potential for the
 CCPC design to improve patient outcomes.
description: Patients diagnosed with congenital heart defects and requiring
 TCPC grafts were selected for this study. The TCPC grafts were initially
 imaged using magnetic resonance imaging (MRI) techniques. Subsequently,
 the MRI data were processed utilizing segmentation software  Mimics
 Medical (materialise.com), to meticulously segment and extract the TCPC
 grafts, generating STL files representing the three-dimensional structure
 of the grafts. The TCPC grafts were then 3D printed. In vitro testing was
 then performed via a custom mock circulatory flow loop. A solution of 60%
 water and 40% glycerin was used to mimic blood viscosity. An
 MRI-compatible pump (CardioFlow 5000 MR, Shelley) was used to recreate the
 patients’ cardiac output and was held constant throughout testing. Four
 ultrasonic flow meters (Onicon, Largo, FL) were used to measure the flow
 of the inlets at the IVC and SVC and the outlets at the left and right
 pulmonary arteries (LPA and RPA, respectively). Ball valves were used to
 achieve the patient specific distribution of flow amongst the vessels as
 observed in their clinical CMR. The mock circulatory flow loop was then
 scanned with 4D flow MRI WIP 785A, and then quantified via 4D flow
 visualization software, ITFlow (www.cfd.life/en/itflow). The same setup was employed for the novel CCPC designs. In terms of the basic demographic information shown here, such as body surface area and age, they were gathered through direct consultation with the patients involved in the study. Specific properties of the TCPC and CCPC graft models, including wall shear stress, energy loss, vorticity, and helicity, were measured and compiled into .csv files. These properties were assessed using the aforementioned ITFlow software. Finally, the 4D DICOM files from the TCPC mock circulatory flow loops are included here. These DICOM files facilitated the segmentation of the grafts and the subsequent creation of precise 3D models used for analysis. These data points were imported into Excel (www.microsoft.com/en-us/microsoft-365/excel) and used to conduct a paired t-test to compare the results from TCPC and CCPC grafts.
description: # 3D modeling and 4D flow data of Total Cavopulmonary Connection (TCPC)
 vs. Convergent Cavopulmonary connection (CCPC)
 This study conducts a
 comprehensive evaluation focused on assessing the feasibility and
 validation of patient-specific convergent cavopulmonary connection (CCPC)
 grafts for individuals with congenital heart defects in comparison with
 the performance of total cavopulmonary connection (TCPC) grafts. The
 datasets incorporated in this submission constitute crucial information
 enabling comprehension of our methodology and replication of our
 experiments using a mock circulatory flow loop. These datasets encompass
 3D models, flow rates, basic demographic information, and 4D Flow DICOMs
 of 11 TCPC models. Additionally, raw CSV measurements from a 4D Flow
 software for both CCPC and TCPC grafts have been included. By means of the
 development and analysis of these datasets, we have effectively
 demonstrated the non-inferiority of the CCPC configuration compared to the
 TCPC design. The CCPC modifications to the Fontan design did not incur
 additional hemodynamic costs and provided improvements in hepatic flow
 distribution. Therefore, it validates the potential for the CCPC design to
 improve patient outcomes. ## Description of the data and file structure
 The dataset contains the following: 1. 3D Models of the 11 TCPC instances
 in STL format. File Name: '3D Models of the 11 TCPC
 Instances.zip'. 2. Cross-sectional flow rates of each model captured
 through 4D analysis. 1. Total flow rate of the whole flow loop circuit for
 each model. 2. Flow rate of each vessel in each model (left pulmonary
 artery, right pulmonary artery, superior vena cava and inferior vena
 cava). File Name: 'Model Flow Rates.csv'. 3. Body surface area
 of the respective patient for each model. File Name: 'Basic
 Demographic Info - Models.xlsx'. 4. 4D Flow DICOM Image sets for all
 11 TCPC models. File Name: '4D Flow DICOM Image sets.zip' 5. 4D
 Flow characteristics of each TCPC Model analyzed through 4D Visualization
 software. 1. Energy loss across time. 2. Right screw and left screw
 helicity across time. 3. Relative and absolute vorticity value across all
 three axes. 4. Wall shear stress across time. Each zip folder is named
 '[model name] 4D Flow Properties.zip'. As you open each folder,
 you will find .csv files named '[model name] [property]'.