DOI: 10.5061/dryad.mt24h
title: Data from: Correlation between either Cupriavidus or Porphyromonas and primary pulmonary tuberculosis found by analysing the microbiota in patients’ bronchoalveolar lavage fluid

description: Pulmonary tuberculosis (TB) has gained attention in recent decades because
 of its rising incidence trend; simultaneously, increasing numbers of
 studies have identified the relationship between microbiota and chronic
 infectious diseases. In our work, we enrolled 32 patients with primary TB
 characterised by unilateral TB lesion formation diagnosed by chest
 radiographic exam. Bronchoalveolar lavage fluid was taken from both lungs.
 Twenty-four healthy people were chosen as controls. Pyrosequencing was
 performed on the V3 hypervariable region of 16S rDNA in all bacterial
 samples and used as a culture-independent method to describe the
 phylogenetic composition of the microbiota. Through pyrosequencing,
 271,764 amplicons were detected in samples and analysed using tools in the
 Ribosomal Database Project (RDP) and bioinformatics. These analyses
 revealed significant differences in the microbiota in the lower
 respiratory tract (LRT) of TB patients compared with healthy controls; in
 contrast, the microbiota of intra/extra-TB lesions were similar. These
 results showed that the dominant bacterial genus in the LRT of TB patients
 was Cupriavidus and not Streptococcus, which resulted in a significant
 change in the microbiota in TB patients. The abundance of Mycobacteria and
 Porphyromonas significantly increased inside TB lesions when compared with
 non-lesion-containing contralateral lungs. From these data, it can be
 concluded that Cupriavidus plays an important role in TB’s secondary
 infection and that in addition to Mycobacteria, Porphyromonas may also be
 a co-factor in lesion formation. The mechanisms underlying this connection
 warrant further research.
description: No.1 TB patient's
 microbiome (Group A)Group A means the
 microbiome from lesion-free lung lobe; Group B means the microbiome from
 lesion-forming lung lobe; Group H means the microbiome from healthy
 individuals.1A_pm.fnaNo.1 TB patient's microbiome (Group B)Group A means the microbiome from lesion-free lung lobe; Group B means the microbiome from lesion-forming lung lobe; Group H means the microbiome from healthy individuals.1B_pm.fnaNo.2 TB patient's microbiome (Group A)Group A means the microbiome from lesion-free lung lobe; Group B means the microbiome from lesion-forming lung lobe; Group H means the microbiome from healthy individuals.2A_pm.fnaNo.2 TB patient's microbiome (Group B)Group A means the microbiome from lesion-free lung lobe; Group B means the microbiome from lesion-forming lung lobe; Group H means the microbiome from healthy individuals.2B_pm.fnaNo.3 TB patient's microbiome (Group A)Group A means the microbiome from lesion-free lung lobe; Group B means the microbiome from lesion-forming lung lobe; Group H means the microbiome from healthy individuals.3A_pm.fnaNo.3 TB patient's microbiome (Group B)Group A means the microbiome from lesion-free lung lobe; Group B means the microbiome from lesion-forming lung lobe; Group H means the microbiome from healthy individuals.3B_pm.fnaNo.4 TB patient's microbiome (Group A)Group A means the microbiome from lesion-free lung lobe; Group B means the microbiome from lesion-forming lung lobe; Group H means the microbiome from healthy individuals.4A_pm.fnaNo.4 TB patient's microbiome (Group B)Group A means the microbiome from lesion-free lung lobe; Group B means the microbiome from lesion-forming lung lobe; Group H means the microbiome from healthy individuals.4B_pm.fnaNo.5 TB patient's microbiome (Group A)Group A means the microbiome from lesion-free lung lobe; Group B means the microbiome from lesion-forming lung lobe; Group H means the microbiome from healthy individuals.5A_pm.fnaNo.5 TB patient's microbiome (Group B)Group A means the microbiome from lesion-free lung lobe; Group B means the microbiome from lesion-forming lung lobe; Group H means the microbiome from healthy individuals.5B_pm.fnaNo.6 TB patient's microbiome (Group A)Group A means the microbiome from lesion-free lung lobe; Group B means the microbiome from lesion-forming lung lobe; Group H means the microbiome from healthy individuals.6A_pm.fnaNo.6 TB patient's microbiome (Group B)Group A means the microbiome from lesion-free lung lobe; Group B means the microbiome from lesion-forming lung lobe; Group H means the microbiome from healthy individuals.6B_pm.fnaNo.7 TB patient's microbiome (Group A)Group A means the microbiome from lesion-free lung lobe; Group B means the microbiome from lesion-forming lung lobe; Group H means the microbiome from healthy individuals.7A_pm.fnaNo.7 TB patient's microbiome (Group B)Group A means the microbiome from lesion-free lung lobe; Group B means the microbiome from lesion-forming lung lobe; Group H means the microbiome from healthy individuals.7B_pm.fnaNo.8 TB patient's microbiome (Group A)Group A means the microbiome from lesion-free lung lobe; Group B means the microbiome from lesion-forming lung lobe; Group H means the microbiome from healthy individuals.8A_pm.fnaNo.8 TB patient's microbiome (Group B)8B_pm.fnaNo.9 TB patient's microbiome (Group A)Group A means the microbiome from lesion-free lung lobe; Group B means the microbiome from lesion-forming lung lobe; Group H means the microbiome from healthy individuals.9A_pm.fnaNo.9 TB patient's microbiome (Group B)Group A means the microbiome from lesion-free lung lobe; Group B means the microbiome from lesion-forming lung lobe; Group H means the microbiome from healthy individuals.9B_pm.fnaNo.10 TB patient's microbiome (Group A)10A_pm.fnaNo.10 TB patient's microbiome (Group B)Group A means the microbiome from lesion-free lung lobe; Group B means the microbiome from lesion-forming lung lobe; Group H means the microbiome from healthy individuals.10B_pm.fnaNo.11 TB patient's microbiome (Group A)Group A means the microbiome from lesion-free lung lobe; Group B means the microbiome from lesion-forming lung lobe; Group H means the microbiome from healthy individuals.11A_pm.fnaNo.11 TB patient's microbiome (Group B)Group A means the microbiome from lesion-free lung lobe; Group B means the microbiome from lesion-forming lung lobe; Group H means the microbiome from healthy individuals.11B_pm.fnaNo.12 TB patient's microbiome (Group A)Group A means the microbiome from lesion-free lung lobe; Group B means the microbiome from lesion-forming lung lobe; Group H means the microbiome from healthy individuals.12A_pm.fnaNo.12 TB patient's microbiome (Group B)Group A means the microbiome from lesion-free lung lobe; Group B means the microbiome from lesion-forming lung lobe; Group H means the microbiome from healthy individuals.12B_pm.fnaNo.13 TB patient's microbiome (Group A)Group A means the microbiome from lesion-free lung lobe; Group B means the microbiome from lesion-forming lung lobe; Group H means the microbiome from healthy individuals.13A_pm.fnaNo.13 TB patient's microbiome (Group B)13B_pm.fnaNo.14 TB patient's microbiome (Group A)Group A means the microbiome from lesion-free lung lobe; Group B means the microbiome from lesion-forming lung lobe; Group H means the microbiome from healthy individuals.14A_pm.fnaNo.14 TB patient's microbiome (Group B)Group A means the microbiome from lesion-free lung lobe; Group B means the microbiome from lesion-forming lung lobe; Group H means the microbiome from healthy individuals.14B_pm.fnaNo.15 TB patient's microbiome (Group A)15A_pm.fnaNo.15 TB patient's microbiome (Group B)Group A means the microbiome from lesion-free lung lobe; Group B means the microbiome from lesion-forming lung lobe; Group H means the microbiome from healthy individuals.15B_pm.fnaNo.16 TB patient's microbiome (Group A)Group A means the microbiome from lesion-free lung lobe; Group B means the microbiome from lesion-forming lung lobe; Group H means the microbiome from healthy individuals.16A_pm.fnaNo.16 TB patient's microbiome (Group B)Group A means the microbiome from lesion-free lung lobe; Group B means the microbiome from lesion-forming lung lobe; Group H means the microbiome from healthy individuals.16B_pm.fnaNo.17 TB patient's microbiome (Group A)Group A means the microbiome from lesion-free lung lobe; Group B means the microbiome from lesion-forming lung lobe; Group H means the microbiome from healthy individuals.17A_pm.fnaNo.17 TB patient's microbiome (Group B)Group A means the microbiome from lesion-free lung lobe; Group B means the microbiome from lesion-forming lung lobe; Group H means the microbiome from healthy individuals.17B_pm.fnaNo.18 TB patient's microbiome (Group A)Group A means the microbiome from lesion-free lung lobe; Group B means the microbiome from lesion-forming lung lobe; Group H means the microbiome from healthy individuals.18A_pm.fnaNo.18 TB patient's microbiome (Group B)Group A means the microbiome from lesion-free lung lobe; Group B means the microbiome from lesion-forming lung lobe; Group H means the microbiome from healthy individuals.18B_pm.fnaNo.19 TB patient's microbiome (Group A)Group A means the microbiome from lesion-free lung lobe; Group B means the microbiome from lesion-forming lung lobe; Group H means the microbiome from healthy individuals.19A_pm.fnaNo.19 TB patient's microbiome (Group B)Group A means the microbiome from lesion-free lung lobe; Group B means the microbiome from lesion-forming lung lobe; Group H means the microbiome from healthy individuals.19B_pm.fnaNo.20 TB patient's microbiome (Group A)Group A means the microbiome from lesion-free lung lobe; Group B means the microbiome from lesion-forming lung lobe; Group H means the microbiome from healthy individuals.20A_pm.fnaNo.20 TB patient's microbiome (Group B)Group A means the microbiome from lesion-free lung lobe; Group B means the microbiome from lesion-forming lung lobe; Group H means the microbiome from healthy individuals.20B_pm.fnaNo.21 TB patient's microbiome (Group A)Group A means the microbiome from lesion-free lung lobe; Group B means the microbiome from lesion-forming lung lobe; Group H means the microbiome from healthy individuals.21A_pm.fnaNo.21 TB patient's microbiome (Group B)21B_pm.fnaNo.22 TB patient's microbiome (Group A)Group A means the microbiome from lesion-free lung lobe; Group B means the microbiome from lesion-forming lung lobe; Group H means the microbiome from healthy individuals.22A_pm.fnaNo.22 TB patient's microbiome (Group B)Group A means the microbiome from lesion-free lung lobe; Group B means the microbiome from lesion-forming lung lobe; Group H means the microbiome from healthy individuals.22B_pm.fnaNo.23 TB patient's microbiome (Group A)Group A means the microbiome from lesion-free lung lobe; Group B means the microbiome from lesion-forming lung lobe; Group H means the microbiome from healthy individuals.23A_pm.fnaNo.23 TB patient's microbiome (Group B)Group A means the microbiome from lesion-free lung lobe; Group B means the microbiome from lesion-forming lung lobe; Group H means the microbiome from healthy individuals.23B_pm.fnaNo.24 TB patient's microbiome (Group A)Group A means the microbiome from lesion-free lung lobe; Group B means the microbiome from lesion-forming lung lobe; Group H means the microbiome from healthy individuals.24A_pm.fnaNo.24 TB patient's microbiome (Group B)Group A means the microbiome from lesion-free lung lobe; Group B means the microbiome from lesion-forming lung lobe; Group H means the microbiome from healthy individuals.24B_pm.fnaNo.25 TB patient's microbiome (Group A)Group A means the microbiome from lesion-free lung lobe; Group B means the microbiome from lesion-forming lung lobe; Group H means the microbiome from healthy individuals.25A_pm.fnaNo.25 TB patient's microbiome (Group B)Group A means the microbiome from lesion-free lung lobe; Group B means the microbiome from lesion-forming lung lobe; Group H means the microbiome from healthy individuals.25B_pm.fnaNo.26 TB patient's microbiome (Group A)Group A means the microbiome from lesion-free lung lobe; Group B means the microbiome from lesion-forming lung lobe; Group H means the microbiome from healthy individuals.26A_pm.fnaNo.26 TB patient's microbiome (Group B)Group A means the microbiome from lesion-free lung lobe; Group B means the microbiome from lesion-forming lung lobe; Group H means the microbiome from healthy individuals.26B_pm.fnaNo.27 TB patient's microbiome (Group A)Group A means the microbiome from lesion-free lung lobe; Group B means the microbiome from lesion-forming lung lobe; Group H means the microbiome from healthy individuals.27A_pm.fnaNo.27 TB patient's microbiome (Group B)Group A means the microbiome from lesion-free lung lobe; Group B means the microbiome from lesion-forming lung lobe; Group H means the microbiome from healthy individuals.27B_pm.fnaNo.28 TB patient's microbiome (Group A)Group A means the microbiome from lesion-free lung lobe; Group B means the microbiome from lesion-forming lung lobe; Group H means the microbiome from healthy individuals.28A_pm.fnaNo.28 TB patient's microbiome (Group B)Group A means the microbiome from lesion-free lung lobe; Group B means the microbiome from lesion-forming lung lobe; Group H means the microbiome from healthy individuals.28B_pm.fnaNo.29 TB patient's microbiome (Group A)Group A means the microbiome from lesion-free lung lobe; Group B means the microbiome from lesion-forming lung lobe; Group H means the microbiome from healthy individuals.29A_pm.fnaNo.29 TB patient's microbiome (Group B)Group A means the microbiome from lesion-free lung lobe; Group B means the microbiome from lesion-forming lung lobe; Group H means the microbiome from healthy individuals.29B_pm.fnaNo.30 TB patient's microbiome (Group A)Group A means the microbiome from lesion-free lung lobe; Group B means the microbiome from lesion-forming lung lobe; Group H means the microbiome from healthy individuals.30A_pm.fnaNo.30 TB patient's microbiome (Group B)Group A means the microbiome from lesion-free lung lobe; Group B means the microbiome from lesion-forming lung lobe; Group H means the microbiome from healthy individuals.30B_pm.fnaNo.31 TB patient's microbiome (Group A)Group A means the microbiome from lesion-free lung lobe; Group B means the microbiome from lesion-forming lung lobe; Group H means the microbiome from healthy individuals.31A_pm.fnaNo.31 TB patient's microbiome (Group B)Group A means the microbiome from lesion-free lung lobe; Group B means the microbiome from lesion-forming lung lobe; Group H means the microbiome from healthy individuals.31B_pm.fnaNo.32 TB patient's microbiome (Group A)Group A means the microbiome from lesion-free lung lobe; Group B means the microbiome from lesion-forming lung lobe; Group H means the microbiome from healthy individuals.32A_pm.fnaNo.32 TB patient's microbiome (Group B)Group A means the microbiome from lesion-free lung lobe; Group B means the microbiome from lesion-forming lung lobe; Group H means the microbiome from healthy individuals.32B_pm.fnaNo.1 Healthy people's microbiome (Group H)Group A means the microbiome from lesion-free lung lobe; Group B means the microbiome from lesion-forming lung lobe; Group H means the microbiome from healthy individuals.N1_pm.fnaNo.2 Healthy people's microbiome (Group H)Group A means the microbiome from lesion-free lung lobe; Group B means the microbiome from lesion-forming lung lobe; Group H means the microbiome from healthy individuals.N2_pm.fnaNo.3 Healthy people's microbiome (Group H)Group A means the microbiome from lesion-free lung lobe; Group B means the microbiome from lesion-forming lung lobe; Group H means the microbiome from healthy individuals.N3_pm.fnaNo.4 Healthy people's microbiome (Group H)Group A means the microbiome from lesion-free lung lobe; Group B means the microbiome from lesion-forming lung lobe; Group H means the microbiome from healthy individuals.N4_pm.fnaNo.5 Healthy people's microbiome (Group H)Group A means the microbiome from lesion-free lung lobe; Group B means the microbiome from lesion-forming lung lobe; Group H means the microbiome from healthy individuals.N5_pm.fnaNo.6 Healthy people's microbiome (Group H)Group A means the microbiome from lesion-free lung lobe; Group B means the microbiome from lesion-forming lung lobe; Group H means the microbiome from healthy individuals.N6_pm.fnaNo.7 Healthy people's microbiome (Group H)Group A means the microbiome from lesion-free lung lobe; Group B means the microbiome from lesion-forming lung lobe; Group H means the microbiome from healthy individuals.N7_pm.fnaNo.8 Healthy people's microbiome (Group H)Group A means the microbiome from lesion-free lung lobe; Group B means the microbiome from lesion-forming lung lobe; Group H means the microbiome from healthy individuals.N8_pm.fnaNo.9 Healthy people's microbiome (Group H)Group A means the microbiome from lesion-free lung lobe; Group B means the microbiome from lesion-forming lung lobe; Group H means the microbiome from healthy individuals.HEA#01.fastaNo.10 Healthy people's microbiome (Group H)HEA#02.fastaNo.11 Healthy people's microbiome (Group H)Group A means the microbiome from lesion-free lung lobe; Group B means the microbiome from lesion-forming lung lobe; Group H means the microbiome from healthy individuals.HEA#03.fastaNo.12 Healthy people's microbiome (Group H)Group A means the microbiome from lesion-free lung lobe; Group B means the microbiome from lesion-forming lung lobe; Group H means the microbiome from healthy individuals.HEA#04.fastaNo.13 Healthy people's microbiome (Group H)Group A means the microbiome from lesion-free lung lobe; Group B means the microbiome from lesion-forming lung lobe; Group H means the microbiome from healthy individuals.HEA#05.fastaNo.14 Healthy people's microbiome (Group H)Group A means the microbiome from lesion-free lung lobe; Group B means the microbiome from lesion-forming lung lobe; Group H means the microbiome from healthy individuals.HEA#06.fastaNo.15 Healthy people's microbiome (Group H)Group A means the microbiome from lesion-free lung lobe; Group B means the microbiome from lesion-forming lung lobe; Group H means the microbiome from healthy individuals.HEA#07.fastaNo.16 Healthy people's microbiome (Group H)Group A means the microbiome from lesion-free lung lobe; Group B means the microbiome from lesion-forming lung lobe; Group H means the microbiome from healthy individuals.HEA#08.fastaNo.17 Healthy people's microbiome (Group H)Group A means the microbiome from lesion-free lung lobe; Group B means the microbiome from lesion-forming lung lobe; Group H means the microbiome from healthy individuals.HEA#09.fastaNo.18 Healthy people's microbiome (Group H)Group A means the microbiome from lesion-free lung lobe; Group B means the microbiome from lesion-forming lung lobe; Group H means the microbiome from healthy individuals.HEA#10.fastaNo.19 Healthy people's microbiome (Group H)Group A means the microbiome from lesion-free lung lobe; Group B means the microbiome from lesion-forming lung lobe; Group H means the microbiome from healthy individuals.HEA#11.fastaNo.20 Healthy people's microbiome (Group H)Group A means the microbiome from lesion-free lung lobe; Group B means the microbiome from lesion-forming lung lobe; Group H means the microbiome from healthy individuals.HEA#12.fastaNo.21 Healthy people's microbiome (Group H)Group A means the microbiome from lesion-free lung lobe; Group B means the microbiome from lesion-forming lung lobe; Group H means the microbiome from healthy individuals.HEA#13.fastaNo.22 Healthy people's microbiome (Group H)Group A means the microbiome from lesion-free lung lobe; Group B means the microbiome from lesion-forming lung lobe; Group H means the microbiome from healthy individuals.HEA#14.fastaNo.23 Healthy people's microbiome (Group H)Group A means the microbiome from lesion-free lung lobe; Group B means the microbiome from lesion-forming lung lobe; Group H means the microbiome from healthy individuals.HEA#15.fastaNo.24 Healthy people's microbiome (Group H)Group A means the microbiome from lesion-free lung lobe; Group B means the microbiome from lesion-forming lung lobe; Group H means the microbiome from healthy individuals.HEA#16.fasta