cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.17608/k6.auckland.2000910.v12
title: ISSP1991: Religion I

description: This was the start of 20 years of successful surveys for the International Social Survey Programme in New Zealand, run by Professor Philip Gendall in the Department of Marketing of Massey University.A verbose rundown on topics follows.Attitudes towards religious behaviours. Topics: Personal estimation of happiness; assessment of responsibility of the state regarding job creation and income levelling; stronger punishment and the death penalty as measures to combat crime; attitude to pre-marital sexual intercourse and affairs; attitude to homosexuality and abortion; judgement on role distribution in marriage and attitude to working women; honesty in paying taxes and attitude to honesty of citizens with the state; trust in institutions such as the Federal Parliament, business, industry, authorities, churches, judiciary and schools. Attitude to non-religious politicians and office-holders; influence on voters as well as government through church leaders; judgement on the power of churches and religious organisations; doubt or firm belief in God; perceived nearness to God; development of personal belief in God; belief in a life after death; belief in the devil, heaven, hell and miracles; conviction regarding the Bible; fatalism; the meaning of life and Christian interpretation of life; contact with the dead; religious ties at a turning point in life; religious affiliation of father, mother and spouse/partner; frequency of church attendance of father and of mother; personal direction of belief and frequency of church attendance in adolescence; frequency of prayer and participation in religious activities. Self-classification of personal religiousness; attitude to school prayer; personal conscience, social rules or God’s laws as basis for deciding between right and wrong; attitudes to prohibition of religious criticism in literature and films; superstition; belief in lucky charms, fortune tellers, wonder doctors, signs of the zodiac and horoscopes; conversion of faith after crucial experience; idea of God; judgement on world and people as good or bad. Living together with partner; type and temporal extent of vocational employment; private or public employer; professional independence and number of employees; superior function and span of control; number of colleagues; union membership; unemployment; party inclination and behaviour at the polls; self-classification on a left-right continuum; religious affiliation; religiousness; self-classification of social class affiliation; residential status; training and employment of spouse/partner as well as parents; size of household; household income. Also encoded were: region; rural or urban area; city size; ethnic identification.
DOI: 10.6084/m9.figshare.1632862
title: Blood alcohol concentration in fatally injured drivers and the efficacy of alcohol policies of the new law on road traffic safety: A retrospective 10-year study in autonomous province of Vojvodina, Republic of Serbia

description: <b>Objective</b>: The aim of this study was primarily to evaluate inebriated fatally injured drivers (FIDs) according to blood alcohol concentration (BAC) in a 10-year period (2004–2013) in Autonomous Province (AP) of Vojvodina, Republic of Serbia, to analyze the efficacy of alcohol polices in the new law on road traffic safety through changes in the number of inebriated FIDs before and after implementation of the law, as well as to identify factors that influence the occurrence of FIDs with BACs above the legal limit. <b>Methods</b>: All data for this retrospective study were obtained from the Centre of Forensic Medicine, Toxicology and Molecular Genetics of Clinical Centre of Vojvodina, Novi Sad. Autopsy records for each case included age, gender, BAC, type of vehicle, and date of accident (year, month, and recalculated day of the week). BAC was determined by gas chromatography with flame ionization detection. Statistical analysis was carried out by chi-square tests and Student's <i>t</i> test, with <i>P</i> &lt; .05 as a statistical significance, and multiple binary logistic regression. <b>Results</b>: Of the 354 inebriated FIDs (60% of all FIDs), the majority had BACs between of 0.031 and 0.3 mg/ml (28%), followed by those with BAC &gt; 2.01 mg/ml (23%). The average BAC of those driving under the influence of alcohol (DUIA) for the whole period was 1.235 ± 1.00 mg/ml and the average number of DUIA/year was 35. Among the total number of FIDs there were significantly more males (93.7%; <i>P</i> &lt; .001) than females (6.3%), though the distribution of intoxicated men and women was not different (<i>P</i> &gt; .05). There was a statistically significant difference in the distribution of sober and inebriated FIDs according to age (<i>P</i> &lt; .001) with the predominance of inebriated FIDs between 21 and 30 years. Although gender and age were found to be significant predictors of BAC above legal limit in FIDs, the area under the receiver operating characteristics (ROC) curve showed that the model had poor discrimination (ROC = 0.673). Of all observed FIDs, 65 cases per year were attributed to the first 5-year period (2004–2009) and 49 to the second 5-year (2010–2013) period, which indicates that there was no statistically significant decrease in the number of FIDs after implementation of the new law. <b>Conclusion</b>: The highest number of intoxicated FIDs during the period in AP Vojvodina were mildly and completely inebriated. In the 4-year post-policy period (2010–2013), the number of FIDs and average BAC levels of inebriated FIDs did not significantly change. The abolition of a permissible BAC should be considered.
DOI: 10.6084/m9.figshare.1632864
title: Human S100A10 plays a crucial role in the acquisition of the endometrial receptivity phenotype

description: In assisted reproduction, about 30% of embryo implantation failures are related to inadequate endometrial receptivity. To identify molecules involved in endometrial receptivity acquisition, we investigated, using a SELDI-TOF approach, the protein expression profile of early-secretory and mid-secretory endometrium samples. Among the proteins upregulated in mid-secretory endometrium, we investigated the function of S100A10 in endometrial receptivity and implantation process. S100A10 was expressed in epithelial and stromal cells of the endometrium of fertile patients during the implantation windows. Conversely, it was downregulated in the mid-secretory endometrium of infertile patients diagnosed as non-receptive. Transcriptome analysis of human endometrial epithelial and stromal cells where S100A10 was silenced by shRNA revealed the deregulation of 37 and 256 genes, respectively, related to components of the extracellular matrix and intercellular connections. Functional annotations of these deregulated genes highlighted alterations of the leukocyte extravasation signaling and angiogenesis pathways that play a crucial role during implantation. S100A10 silencing also affected the migration of primary endometrial epithelial and stromal cells, decidualization and secretory transformation of primary endometrial stromal cells and epithelial cells respectively, and promoted apoptosis in serum-starved endometrial epithelial cells. Our findings identify S100A10 as a player in endometrial receptivity acquisition.
DOI: 10.6084/m9.figshare.1632864.v1
title: Human S100A10 plays a crucial role in the acquisition of the endometrial receptivity phenotype

description: In assisted reproduction, about 30% of embryo implantation failures are related to inadequate endometrial receptivity. To identify molecules involved in endometrial receptivity acquisition, we investigated, using a SELDI-TOF approach, the protein expression profile of early-secretory and mid-secretory endometrium samples. Among the proteins upregulated in mid-secretory endometrium, we investigated the function of S100A10 in endometrial receptivity and implantation process. S100A10 was expressed in epithelial and stromal cells of the endometrium of fertile patients during the implantation windows. Conversely, it was downregulated in the mid-secretory endometrium of infertile patients diagnosed as non-receptive. Transcriptome analysis of human endometrial epithelial and stromal cells where S100A10 was silenced by shRNA revealed the deregulation of 37 and 256 genes, respectively, related to components of the extracellular matrix and intercellular connections. Functional annotations of these deregulated genes highlighted alterations of the leukocyte extravasation signaling and angiogenesis pathways that play a crucial role during implantation. S100A10 silencing also affected the migration of primary endometrial epithelial and stromal cells, decidualization and secretory transformation of primary endometrial stromal cells and epithelial cells respectively, and promoted apoptosis in serum-starved endometrial epithelial cells. Our findings identify S100A10 as a player in endometrial receptivity acquisition.
DOI: 10.6084/m9.figshare.1632862.v2
title: Blood alcohol concentration in fatally injured drivers and the efficacy of alcohol policies of the new law on road traffic safety: A retrospective 10-year study in autonomous province of Vojvodina, Republic of Serbia

description: <b>Objective</b>: The aim of this study was primarily to evaluate inebriated fatally injured drivers (FIDs) according to blood alcohol concentration (BAC) in a 10-year period (2004–2013) in Autonomous Province (AP) of Vojvodina, Republic of Serbia, to analyze the efficacy of alcohol polices in the new law on road traffic safety through changes in the number of inebriated FIDs before and after implementation of the law, as well as to identify factors that influence the occurrence of FIDs with BACs above the legal limit. <b>Methods</b>: All data for this retrospective study were obtained from the Centre of Forensic Medicine, Toxicology and Molecular Genetics of Clinical Centre of Vojvodina, Novi Sad. Autopsy records for each case included age, gender, BAC, type of vehicle, and date of accident (year, month, and recalculated day of the week). BAC was determined by gas chromatography with flame ionization detection. Statistical analysis was carried out by chi-square tests and Student's <i>t</i> test, with <i>P</i> &lt; .05 as a statistical significance, and multiple binary logistic regression. <b>Results</b>: Of the 354 inebriated FIDs (60% of all FIDs), the majority had BACs between of 0.031 and 0.3 mg/ml (28%), followed by those with BAC &gt; 2.01 mg/ml (23%). The average BAC of those driving under the influence of alcohol (DUIA) for the whole period was 1.235 ± 1.00 mg/ml and the average number of DUIA/year was 35. Among the total number of FIDs there were significantly more males (93.7%; <i>P</i> &lt; .001) than females (6.3%), though the distribution of intoxicated men and women was not different (<i>P</i> &gt; .05). There was a statistically significant difference in the distribution of sober and inebriated FIDs according to age (<i>P</i> &lt; .001) with the predominance of inebriated FIDs between 21 and 30 years. Although gender and age were found to be significant predictors of BAC above legal limit in FIDs, the area under the receiver operating characteristics (ROC) curve showed that the model had poor discrimination (ROC = 0.673). Of all observed FIDs, 65 cases per year were attributed to the first 5-year period (2004–2009) and 49 to the second 5-year (2010–2013) period, which indicates that there was no statistically significant decrease in the number of FIDs after implementation of the new law. <b>Conclusion</b>: The highest number of intoxicated FIDs during the period in AP Vojvodina were mildly and completely inebriated. In the 4-year post-policy period (2010–2013), the number of FIDs and average BAC levels of inebriated FIDs did not significantly change. The abolition of a permissible BAC should be considered.
DOI: 10.6084/m9.figshare.1632859
title: Ankle fracture patterns in drivers are associated with femoral fracture, higher BMI, and advanced age

description: <b>Objective</b>: Despite advances in vehicle safety systems, motor vehicle crashes continue to cause ankle fractures. This study attempts to provide insight into the mechanisms of injury and to identify the at-risk population groups. <b>Methods</b>: A study was made of ankle fractures patients treated at an urban level 1 trauma center following motor vehicle crashes, with a concurrent analysis of a nationally representative crash data set. The national data set focused on ankle fractures in drivers involved in frontal crashes. Statistical analysis was applied to the national data set to identify factors associated with fracture risk. <b>Results</b>: Malleolar fractures occurred most frequently in the driver's right foot due to pedal interaction. The majority of complex/open fractures occurred in the left foot due to interaction with the vehicle floor. These fractures occurred in association with a femoral fracture, but their broad injury pattern suggests a range of fracture causation mechanisms. The statistical analysis indicated that the risk of fracture increased with increasing driver body mass index (BMI) and age. <b>Conclusions</b>: Efforts to reduce the risk of driver ankle injury should focus on right foot and pedal interaction. The range of injury patterns identified here suggest that efforts to minimize driver ankle fracture risk will likely need to consider injury tolerances for flexion, pronation/supination, and axial loading in order to capture the full range of injury mechanisms. In the clinical environment, physicians examining drivers after a frontal crash should consider those who are older or obese or who have severe femoral injury without concurrent head injury as highly suspicious for an ankle injury.
DOI: 10.6084/m9.figshare.1632862.v1
title: Blood alcohol concentration in fatally injured drivers and the efficacy of alcohol policies of the new law on road traffic safety - a retrospective 10-year study in Autonomous Province of Vojvodina, Republic of Serbia

description: ABSTRACT<b>Objective</b>: The aim of this study was primarily to evaluate inebriated fatally injured drivers (FIDs) according to blood alcohol concentration (BAC), in 10-year period (2004–2013) in Autonomous Province of Vojvodina, Republic of Serbia, to analyse the efficacy alcohol polices in new law on road traffic safety through the changes of number of inebriated FIDs before and after the law implementation, as well as to identify factors that influence the occurrence of FIDs with BAC above legal limit.<b>Methods</b>: All the data for this retrospective study were obtained from Centre of Forensic Medicine, Toxicology and Molecular Genetics of Clinical Centre of Vojvodina, Novi Sad. Autopsy record of each case for this analysis included: age, gender, BAC, type of the vehicle, and date of the accident (year, month, and recalculated day of the week). BAC was determined by gas chromatography with flame ionisation detection. The statistical analysis was carried out by Chi-square test and Student's T test, with p&lt;0.05 as a statistical significance, and multiple binary logistic regression.<b>Results</b>: Of the total of 354 inebriated FIDs (60% of all FIDs), the majority was with BAC category of 0.031–0.3 mg/ml (28%), followed by those with BAC &gt; 2.01 mg/ml (23%). The average BAC of DUIA for whole period was 1.235±1.00 mg/ml and the average number of DUIA/year was 35. Among total number of FIDs the male gender was significantly dominant (93.7%; p&lt;0.001) vs. females (6.3%) while the distribution of intoxicated among men and women was not different (p&gt;0.05). There was statistically significant difference in the distribution of sober and inebriated FIDs according to age categories (p&lt;0.001) with the predominance of inebriated FIDs referred to the one of 21–30 years. Although gender and age were found to be significant predictors of BAC above legal limit in FIDs, the area under ROC curve showed that the model had poor discrimination (ROC = 0.673). Of all observed FIDs 65 cases per year were attributed to the first period (2004–2009) and 49 ones to the second one (2010–2013) which made no statistically significant decrease of the number of FIDs after the new law implementation.<b>Conclusion</b>: The highest number of drunken FIDs during observed period in AP Vojvodina was mildly and completely inebriated. In 4-year post-policy period (2010–2013), the number of FIDs and average BAC levels of inebriated FIDs were not significantly changed. The abolition of permissible BAC should be considered.
DOI: 10.6084/m9.figshare.1632859.v2
title: Ankle fracture patterns in drivers are associated with femoral fracture, higher BMI, and advanced age

description: <b>Objective</b>: Despite advances in vehicle safety systems, motor vehicle crashes continue to cause ankle fractures. This study attempts to provide insight into the mechanisms of injury and to identify the at-risk population groups. <b>Methods</b>: A study was made of ankle fractures patients treated at an urban level 1 trauma center following motor vehicle crashes, with a concurrent analysis of a nationally representative crash data set. The national data set focused on ankle fractures in drivers involved in frontal crashes. Statistical analysis was applied to the national data set to identify factors associated with fracture risk. <b>Results</b>: Malleolar fractures occurred most frequently in the driver's right foot due to pedal interaction. The majority of complex/open fractures occurred in the left foot due to interaction with the vehicle floor. These fractures occurred in association with a femoral fracture, but their broad injury pattern suggests a range of fracture causation mechanisms. The statistical analysis indicated that the risk of fracture increased with increasing driver body mass index (BMI) and age. <b>Conclusions</b>: Efforts to reduce the risk of driver ankle injury should focus on right foot and pedal interaction. The range of injury patterns identified here suggest that efforts to minimize driver ankle fracture risk will likely need to consider injury tolerances for flexion, pronation/supination, and axial loading in order to capture the full range of injury mechanisms. In the clinical environment, physicians examining drivers after a frontal crash should consider those who are older or obese or who have severe femoral injury without concurrent head injury as highly suspicious for an ankle injury.
DOI: 10.6084/m9.figshare.1632859.v1
title: Ankle Fracture Patterns in Drivers are Associated with Femoral Fracture, Higher BMI and Advanced Age

description: Objective: Despite advances in vehicle safety systems, motor vehicle crashes continue to cause ankle fractures. This study attempts to provide insight into the mechanisms of injury and to identify the at-risk population groups.Methods: A study was made of ankle fractures patients treated at an urban Level 1 trauma center following motor vehicle crashes, with a concurrent analysis of a nationally representative crash data set. The national data set focused on ankle fractures in drivers involved in frontal crashes. Statistical analysis was applied to the national data set to identify factors associated with fracture risk.Results: Malleolar fractures occurred most frequently in the driver's right foot due to pedal interaction. The majority of complex/open fractures occurred in the left foot due to interaction with the vehicle floor. These fractures occurred in association with a femoral fracture, but their broad injury pattern suggests a range of fracture causation mechanisms. The statistical analysis indicated that the risk of fracture increased with increasing driver BMI and age.Conclusions: Efforts to reduce the risk of driver ankle injury should focus on right foot and pedal interaction. The range of injury patterns identified here suggest that efforts to minimize driver ankle fracture risk will likely need to consider injury tolerances for flexion, pronation/supination, and axial loading in order to capture the full range of injury mechanisms. In the clinical environment, physicians examining drivers after a frontal crash should consider those who are older, obese or who have severe femoral injury without concurrent head injury, as highly suspicious for an ankle injury.
DOI: 10.6084/m9.figshare.1632854
title: Cost-effectiveness of vortioxetine <i>versus</i> venlafaxine (extended release) in the treatment of major depressive disorder in South Korea

description: <b>Objective</b>: To assess the cost-effectiveness of vortioxetine <i>versus</i> venlafaxine XR (extended-release) in major depressive disorder (MDD) patients in South Korea. <b>Methods</b>: A 1-year cost-effectiveness analysis from a limited societal perspective was performed using a combined model consisting of a decision-tree and a Markov model. Patients entered the model when initiating or switching antidepressant treatment following inadequate response to previous treatment. Remission, relapse and recovery were the main health states. <b>Results</b>: Vortioxetine dominated venlafaxine XR, with quality-adjusted life year (QALY) gains of 0.0131 and cost savings of KRW 623,229/year [US$530/year] from a limited societal perspective. Safety contributed more than efficacy to the incremental QALY gains. More patients were in recovery after initial treatment and after 1 year with vortioxetine (31%, 40%) compared to venlafaxine XR (23%, 36%). Vortioxetine remained dominant in 98% of probabilistic simulations. <b>Conclusion</b>: Vortioxetine dominated venlafaxine XR in South Korea and is a relevant treatment option for MDD patients initiating or switching therapy.
DOI: 10.6084/m9.figshare.1632855
title: The aminoacyl-tRNA synthetases of <i>Drosophila melanogaster</i>

description: Aminoacyl-tRNA synthetases (aaRSs) ligate amino acids to their cognate tRNAs, allowing them to decode the triplet code during translation. Through different mechanisms aaRSs also perform several non-canonical functions in transcription, translation, apoptosis, angiogenesis and inflammation. <i>Drosophila</i> has become a preferred system to model human diseases caused by mutations in <i>aaRS</i> genes, to dissect effects of reduced translation or non-canonical activities, and to study aminoacylation and translational fidelity. However, the lack of a systematic annotation of this gene family has hampered such studies. Here, we report the identification of the entire set of <i>aaRS</i> genes in the fly genome and we predict their roles based on experimental evidence and/or orthology. Further, we propose a new, systematic and logical nomenclature for aaRSs. We also review the research conducted on <i>Drosophila</i> aaRSs to date. Together, our work provides the foundation for further research in the fly aaRS field.