DOI: 10.5281/zenodo.12550792
title: TGF-β neutralization attenuates tumor residency of activated T cells to enhance systemic immunity in mice

description: Deep TCR sequencing was performed using the TCR Profiling Kit from MiLaboratories (Mouse α/β TCR RNA; Kit MiLaboratories; TMMR-001). Deep TCR sequencing was analyzed using the MiXCR software from MiLaboratories per manufacturer's recommendations. The files correspond to the TCR-beta sequences.The files are named as follows:

 

   


file_name
cell type sequenced
tissue of origin
treatment
mouse_id


21BA1dLN.clones_TRB.tsv
T cells
tumor-draining lymph node
bintrafusp alpha
1


23BA2dLN.clones_TRB.tsv
T cells
tumor-draining lymph node
bintrafusp alpha
2


25BA3dLN.clones_TRB.tsv
T cells
tumor-draining lymph node
bintrafusp alpha
3


27BA4dLN.clones_TRB.tsv
T cells
tumor-draining lymph node
bintrafusp alpha
4


29BA5dLN.clones_TRB.tsv
T cells
tumor-draining lymph node
bintrafusp alpha
5


22BA1SP.clones_TRB.tsv
T cells
spleen
bintrafusp alpha
1


24BA2SP.clones_TRB.tsv
T cells
spleen
bintrafusp alpha
2


26BA3SP.clones_TRB.tsv
T cells
spleen
bintrafusp alpha
3


28BA4SP.clones_TRB.tsv
T cells
spleen
bintrafusp alpha
4


30BA5SP.clones_TRB.tsv
T cells
spleen
bintrafusp alpha
5


31CON1dLN.clones_TRB.tsv
T cells
tumor-draining lymph node
control
6


33CON2dLN.clones_TRB.tsv
T cells
tumor-draining lymph node
control
7


35CON3dLN.clones_TRB.tsv
T cells
tumor-draining lymph node
control
8


37CON4dLN.clones_TRB.tsv
T cells
tumor-draining lymph node
control
9


39CON5dLN.clones_TRB.tsv
T cells
tumor-draining lymph node
control
10


32CON1SP.clones_TRB.tsv
T cells
spleen
control
6


34CON2SP.clones_TRB.tsv
T cells
spleen
control
7


36CON3SP.clones_TRB.tsv
T cells
spleen
control
8


38CON4SP.clones_TRB.tsv
T cells
spleen
control
9


40CON5SP.clones_TRB.tsv
T cells
spleen
control
10


1aPDL11dLN.clones_TRB.tsv
T cells
tumor-draining lymph node
anti-PDL1 antibody
11


3aPDL12dLN.clones_TRB.tsv
T cells
tumor-draining lymph node
anti-PDL1 antibody
12


5aPDL13dLN.clones_TRB.tsv
T cells
tumor-draining lymph node
anti-PDL1 antibody
13


7aPDL14dLN.clones_TRB.tsv
T cells
tumor-draining lymph node
anti-PDL1 antibody
14


9aPDL15dLN.clones_TRB.tsv
T cells
tumor-draining lymph node
anti-PDL1 antibody
15


2aPDL11SP.clones_TRB.tsv
T cells
spleen
anti-PDL1 antibody
11


4aPDL12SP.clones_TRB.tsv
T cells
spleen
anti-PDL1 antibody
12


6aPDL13SP.clones_TRB.tsv
T cells
spleen
anti-PDL1 antibody
13


8aPDL14SP.clones_TRB.tsv
T cells
spleen
anti-PDL1 antibody
14


10aPDL15SP.clones_TRB.tsv
T cells
spleen
anti-PDL1 antibody
15


11aTGFB1dLN.clones_TRB.tsv
T cells
tumor-draining lymph node
anti-TGF-beta antibody
16


13aTGFB2dLN.clones_TRB.tsv
T cells
tumor-draining lymph node
anti-TGF-beta antibody
17


15aTGFB3dLN.clones_TRB.tsv
T cells
tumor-draining lymph node
anti-TGF-beta antibody
18


17aTGFB4dLN.clones_TRB.tsv
T cells
tumor-draining lymph node
anti-TGF-beta antibody
19


19aTGFB5dLN.clones_TRB.tsv
T cells
tumor-draining lymph node
anti-TGF-beta antibody
20


12aTGFB1SP.clones_TRB.tsv
T cells
spleen
anti-TGF-beta antibody
16


14aTGFB2SP.clones_TRB.tsv
T cells
spleen
anti-TGF-beta antibody
17


16aTGFB3SP.clones_TRB.tsv
T cells
spleen
anti-TGF-beta antibody
18


18aTGFB4SP.clones_TRB.tsv
T cells
spleen
anti-TGF-beta antibody
19


20aTGFB5SP.clones_TRB.tsv
T cells
spleen
anti-TGF-beta antibody
20