cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.5802459
title: Supplementary Material for: Stereoselective Inhibition of Renal Basolateral Human Organic Anion Transporter 3 by Lansoprazole Enantiomers

description: Lansoprazole, a proton pump inhibitor, potently inhibits human organic anion transporter, hOAT3 (SLC22A8). Lansoprazole has an asymmetric atom in its structure and is clinically administered as a racemic mixture of (R)-and (S)-enantiomers. However, little is known about the stereoselective inhibitory potencies of lansoprazole against hOAT3 and its homolog, hOAT1. In the present study, the stereoselective inhibitory effect of lansoprazole was evaluated using hOAT1-and hOAT3-expressing cultured cells. hOAT1 and hOAT3 transported [<sup>14</sup>C]<i>p</i>-aminohippurate and [<sup>3</sup>H]estrone-3-sulfate (ES) with Michaelis-Menten constants of 29.8 ± 4.0 and 30.1 ± 9.0 µmol/L respectively. Lansoprazole enantiomers inhibited hOAT1- and hOAT3-mediated transport of each substrate in a concentration-dependent manner. The IC<sub>50</sub> value of (S)-lansoprazole against hOAT3-mediated transport of [<sup>3</sup>H]ES (0.61 ± 0.08 µmol/L) was significantly lower than that of (R)-lansoprazole (1.75 ± 0.31 µmol/L). In contrast, stereoselectivity was not demonstrated for the inhibition of hOAT1. Furthermore, (S)-lansoprazole inhibited hOAT3-mediated transport of pemetrexed and methotrexate (hOAT3 substrates) more strongly than the corresponding (R)-lansoprazole. This study is the first to demonstrate that the stereoselective inhibitory potency of (S)-lansoprazole against hOAT3 is greater than that of (R)-lansoprazole. The present findings provide novel information about the drug interactions associated with lansoprazole.
DOI: 10.6084/m9.figshare.5802459.v1
title: Supplementary Material for: Stereoselective Inhibition of Renal Basolateral Human Organic Anion Transporter 3 by Lansoprazole Enantiomers

description: Lansoprazole, a proton pump inhibitor, potently inhibits human organic anion transporter, hOAT3 (SLC22A8). Lansoprazole has an asymmetric atom in its structure and is clinically administered as a racemic mixture of (R)-and (S)-enantiomers. However, little is known about the stereoselective inhibitory potencies of lansoprazole against hOAT3 and its homolog, hOAT1. In the present study, the stereoselective inhibitory effect of lansoprazole was evaluated using hOAT1-and hOAT3-expressing cultured cells. hOAT1 and hOAT3 transported [<sup>14</sup>C]<i>p</i>-aminohippurate and [<sup>3</sup>H]estrone-3-sulfate (ES) with Michaelis-Menten constants of 29.8 ± 4.0 and 30.1 ± 9.0 µmol/L respectively. Lansoprazole enantiomers inhibited hOAT1- and hOAT3-mediated transport of each substrate in a concentration-dependent manner. The IC<sub>50</sub> value of (S)-lansoprazole against hOAT3-mediated transport of [<sup>3</sup>H]ES (0.61 ± 0.08 µmol/L) was significantly lower than that of (R)-lansoprazole (1.75 ± 0.31 µmol/L). In contrast, stereoselectivity was not demonstrated for the inhibition of hOAT1. Furthermore, (S)-lansoprazole inhibited hOAT3-mediated transport of pemetrexed and methotrexate (hOAT3 substrates) more strongly than the corresponding (R)-lansoprazole. This study is the first to demonstrate that the stereoselective inhibitory potency of (S)-lansoprazole against hOAT3 is greater than that of (R)-lansoprazole. The present findings provide novel information about the drug interactions associated with lansoprazole.
DOI: 10.6084/m9.figshare.5802450
title: Supplementary Material for: Microstructure of Strategic White Matter Tracts and Cognition in Memory Clinic Patients with Vascular Brain Injury

description: <b><i>Background:</i></b> White matter injury is an important factor for cognitive impairment in memory clinic patients. We determined the added value of diffusion tensor imaging (DTI) of strategic white matter tracts in explaining variance in cognition in memory clinic patients with vascular brain injury. <b><i>Methods:</i></b> We included 159 patients. Conventional MRI markers (white matter hyperintensity volume, lacunes, nonlacunar infarcts, brain atrophy, and microbleeds), and fractional anisotropy and mean diffusivity (MD) of the whole brain white matter and of 18 white matter tracts were related to cognition using linear regression and Bayesian network analysis. <b><i>Results:</i></b> On top of all conventional MRI markers combined, MD of the whole brain white matter explained an additional 3.4% (<i>p</i> = 0.014), 7.8% (<i>p</i> &lt; 0.001), and 1.2% (<i>p</i> = 0.119) variance in executive functioning, speed, and memory, respectively. The Bayesian analyses of regional DTI measures identified strategic tracts for executive functioning (right superior longitudinal fasciculus), speed (left corticospinal tract), and memory (left uncinate fasciculus). MD within these tracts explained an additional 3.4% (<i>p</i> = 0.012), 3.8% (<i>p</i> = 0.007), and 2.1% (<i>p</i> = 0.041) variance in executive functioning, speed, and memory, respectively, on top of all conventional MRI and global DTI markers combined. <b><i>Conclusion:</i></b> In memory clinic patients with vascular brain injury, DTI of strategic white matter tracts has a significant added value in explaining variance in cognitive functioning.
DOI: 10.6084/m9.figshare.5802450.v1
title: Supplementary Material for: Microstructure of Strategic White Matter Tracts and Cognition in Memory Clinic Patients with Vascular Brain Injury

description: <b><i>Background:</i></b> White matter injury is an important factor for cognitive impairment in memory clinic patients. We determined the added value of diffusion tensor imaging (DTI) of strategic white matter tracts in explaining variance in cognition in memory clinic patients with vascular brain injury. <b><i>Methods:</i></b> We included 159 patients. Conventional MRI markers (white matter hyperintensity volume, lacunes, nonlacunar infarcts, brain atrophy, and microbleeds), and fractional anisotropy and mean diffusivity (MD) of the whole brain white matter and of 18 white matter tracts were related to cognition using linear regression and Bayesian network analysis. <b><i>Results:</i></b> On top of all conventional MRI markers combined, MD of the whole brain white matter explained an additional 3.4% (<i>p</i> = 0.014), 7.8% (<i>p</i> &lt; 0.001), and 1.2% (<i>p</i> = 0.119) variance in executive functioning, speed, and memory, respectively. The Bayesian analyses of regional DTI measures identified strategic tracts for executive functioning (right superior longitudinal fasciculus), speed (left corticospinal tract), and memory (left uncinate fasciculus). MD within these tracts explained an additional 3.4% (<i>p</i> = 0.012), 3.8% (<i>p</i> = 0.007), and 2.1% (<i>p</i> = 0.041) variance in executive functioning, speed, and memory, respectively, on top of all conventional MRI and global DTI markers combined. <b><i>Conclusion:</i></b> In memory clinic patients with vascular brain injury, DTI of strategic white matter tracts has a significant added value in explaining variance in cognitive functioning.
DOI: 10.6084/m9.figshare.5802282
title: Improving Privacy and Security in Multi-Tenant Cloud ERP Systems

description: This paper discusses cloud ERP security challenges and their existing solutions. Initially, a set of definitions associated with ERP systems, cloud computing, and multi-tenancy, along with their respective challenges and issues regarding security and privacy, are provided. Next, a set of security challenges is listed, discussed, and mapped to the existing solutions to solve these problems. This thesis aims to build an effective approach to the cloud ERP security management model in terms of data storage, data virtualization, data isolation, and access security in cloud ERP. The following proposed techniques are used to improve the security for multi-tenant SaaS: database virtualization, implementation of data encryption and search functionality on databases and developed systems, distribution of data between tenant and ERP providers, secure application deployment in multi-tenant environments, implementation of the authentication and developed systems together as a two-factor authentication, and improved user access control for multi-tenant ERP clouds.
DOI: 10.6084/m9.figshare.5802276
title: data.xlsx

description: Data set for mixing ratios of VOCs<br>
DOI: 10.6084/m9.figshare.5802276.v1
title: data.xlsx

description: Data set for mixing ratios of VOCs<br>
DOI: 10.6084/m9.figshare.5802270
title: Additional file 8: Table S5. of A novel genomic signature predicting FDG uptake in diverse metastatic tumors

description: List of PLS-3 probes with VIP values equal or greater than 1 along with their regression coefficients. (XLSX 34 kb)
DOI: 10.6084/m9.figshare.5802270.v1
title: Additional file 8: Table S5. of A novel genomic signature predicting FDG uptake in diverse metastatic tumors

description: List of PLS-3 probes with VIP values equal or greater than 1 along with their regression coefficients. (XLSX 34 kb)
DOI: 10.6084/m9.figshare.5802261
title: Additional file 5: Figure S1. of A novel genomic signature predicting FDG uptake in diverse metastatic tumors

description: Selected clusters identified in the Protein Protein Interaction (PPI) subnetworks obtained from the signature genes in the STRING 10.0 PPI database. Figure S2. Goodness of fit of PLS-3 in the training set. a) Goodnes of fit including Pearson correlation of measured vs predicted SUV values b) Residuals of third component. No pattern is apparent in the residuals distribution c) Estimated goodness of fit after 10-fold CV. (ZIP 242Â kb)
DOI: 10.6084/m9.figshare.5802261.v1
title: Additional file 5: Figure S1. of A novel genomic signature predicting FDG uptake in diverse metastatic tumors

description: Selected clusters identified in the Protein Protein Interaction (PPI) subnetworks obtained from the signature genes in the STRING 10.0 PPI database. Figure S2. Goodness of fit of PLS-3 in the training set. a) Goodnes of fit including Pearson correlation of measured vs predicted SUV values b) Residuals of third component. No pattern is apparent in the residuals distribution c) Estimated goodness of fit after 10-fold CV. (ZIP 242Â kb)
DOI: 10.6084/m9.figshare.5802231
title: Additional file 8: of Expansion of cytochrome P450 and cathepsin genes in the generalist herbivore brown marmorated stink bug

description: Predicted Pfam domains in Halyomorpha halys transcripts. This file contains two spreadsheets. The “Detailed” spreadsheet contains putative Pfam assignments to individual H. halys transcripts, while the “Summary” spreadsheet lists a summary of the counts of all Pfams identified. (XLSX 3871 kb)
DOI: 10.6084/m9.figshare.5802231.v1
title: Additional file 8: of Expansion of cytochrome P450 and cathepsin genes in the generalist herbivore brown marmorated stink bug

description: Predicted Pfam domains in Halyomorpha halys transcripts. This file contains two spreadsheets. The “Detailed” spreadsheet contains putative Pfam assignments to individual H. halys transcripts, while the “Summary” spreadsheet lists a summary of the counts of all Pfams identified. (XLSX 3871 kb)
DOI: 10.6084/m9.figshare.5802225
title: Additional file 7: of Expansion of cytochrome P450 and cathepsin genes in the generalist herbivore brown marmorated stink bug

description: Putative KEGG pathways assignments for Halyomorpha halys transcripts (XLSX 61Â kb)
DOI: 10.6084/m9.figshare.5802225.v1
title: Additional file 7: of Expansion of cytochrome P450 and cathepsin genes in the generalist herbivore brown marmorated stink bug

description: Putative KEGG pathways assignments for Halyomorpha halys transcripts (XLSX 61Â kb)
DOI: 10.6084/m9.figshare.5802222
title: Additional file 6: of Expansion of cytochrome P450 and cathepsin genes in the generalist herbivore brown marmorated stink bug

description: Gene ontology assignments for Halyomorpha halys transcriptome assembly. This file contains four spreadsheets. The “Gene Ontology” spreadsheet lists all three domains combined for each transcript whereas remaining three lists each domain (i.e. biological process, molecular function, and cellular component) separately. (XLSX 2529 kb)
DOI: 10.6084/m9.figshare.5802222.v1
title: Additional file 6: of Expansion of cytochrome P450 and cathepsin genes in the generalist herbivore brown marmorated stink bug

description: Gene ontology assignments for Halyomorpha halys transcriptome assembly. This file contains four spreadsheets. The “Gene Ontology” spreadsheet lists all three domains combined for each transcript whereas remaining three lists each domain (i.e. biological process, molecular function, and cellular component) separately. (XLSX 2529 kb)
DOI: 10.6084/m9.figshare.5802213
title: Additional file 5: of Expansion of cytochrome P450 and cathepsin genes in the generalist herbivore brown marmorated stink bug

description: Results of InterProScan search performed on Halyomorpha halys transcripts having no match during blastx search to RefSeq database (XLSX 2047Â kb)
DOI: 10.6084/m9.figshare.5802213.v1
title: Additional file 5: of Expansion of cytochrome P450 and cathepsin genes in the generalist herbivore brown marmorated stink bug

description: Results of InterProScan search performed on Halyomorpha halys transcripts having no match during blastx search to RefSeq database (XLSX 2047Â kb)
DOI: 10.6084/m9.figshare.5802198
title: Additional file 4: of Expansion of cytochrome P450 and cathepsin genes in the generalist herbivore brown marmorated stink bug

description: Results of blastn search performed on Halyomorpha halys transcripts having no match during blastx search to RefSeq database (XLSX 1989Â kb)
DOI: 10.6084/m9.figshare.5802198.v1
title: Additional file 4: of Expansion of cytochrome P450 and cathepsin genes in the generalist herbivore brown marmorated stink bug

description: Results of blastn search performed on Halyomorpha halys transcripts having no match during blastx search to RefSeq database (XLSX 1989Â kb)
DOI: 10.6084/m9.figshare.5802189
title: Additional file 3: of Expansion of cytochrome P450 and cathepsin genes in the generalist herbivore brown marmorated stink bug

description: Putative ortholog and annotation details for Halyomorpha halys transcriptome assembly (XLSX 5983Â kb)
DOI: 10.6084/m9.figshare.5802189.v1
title: Additional file 3: of Expansion of cytochrome P450 and cathepsin genes in the generalist herbivore brown marmorated stink bug

description: Putative ortholog and annotation details for Halyomorpha halys transcriptome assembly (XLSX 5983Â kb)
DOI: 10.6084/m9.figshare.5802177
title: Additional file 2: of Expansion of cytochrome P450 and cathepsin genes in the generalist herbivore brown marmorated stink bug

description: TheÂ GenBank accession numbers or transcripts of various protein sequences used in the phylogenetic analysis of cathepsins and P450s. (XLSX 38Â kb)
DOI: 10.6084/m9.figshare.5802177.v1
title: Additional file 2: of Expansion of cytochrome P450 and cathepsin genes in the generalist herbivore brown marmorated stink bug

description: TheÂ GenBank accession numbers or transcripts of various protein sequences used in the phylogenetic analysis of cathepsins and P450s. (XLSX 38Â kb)
DOI: 10.6084/m9.figshare.5802174
title: Additional file 6: Figure S4. of microRNAs associated with early neural crest development in Xenopus laevis

description: Alignment files of small RNAs to the hairpins. (TXT 1995Â kb)
DOI: 10.6084/m9.figshare.5802174.v1
title: Additional file 6: Figure S4. of microRNAs associated with early neural crest development in Xenopus laevis

description: Alignment files of small RNAs to the hairpins. (TXT 1995Â kb)
DOI: 10.6084/m9.figshare.5802165
title: Additional file 1: of Expansion of cytochrome P450 and cathepsin genes in the generalist herbivore brown marmorated stink bug

description: Primer sequences for RT-PCR of cathepsin-L and P450 genes in Halyomorpha halys (XLSX 14Â kb)
DOI: 10.6084/m9.figshare.5802165.v1
title: Additional file 1: of Expansion of cytochrome P450 and cathepsin genes in the generalist herbivore brown marmorated stink bug

description: Primer sequences for RT-PCR of cathepsin-L and P450 genes in Halyomorpha halys (XLSX 14Â kb)
DOI: 10.6084/m9.figshare.5802162
title: Additional file 5: Figure S3. of microRNAs associated with early neural crest development in Xenopus laevis

description: Hairpin sequences of all miRNAs. (TXT 67Â kb)
DOI: 10.6084/m9.figshare.5802162.v1
title: Additional file 5: Figure S3. of microRNAs associated with early neural crest development in Xenopus laevis

description: Hairpin sequences of all miRNAs. (TXT 67Â kb)
DOI: 10.6084/m9.figshare.5802141
title: Additional file 3 Table S2. of microRNAs associated with early neural crest development in Xenopus laevis

description: Mature sequences for all miRNAs. (XLSX 59Â kb)
DOI: 10.6084/m9.figshare.5802141.v1
title: Additional file 3 Table S2. of microRNAs associated with early neural crest development in Xenopus laevis

description: Mature sequences for all miRNAs. (XLSX 59Â kb)
DOI: 10.6084/m9.figshare.5802123
title: Additional file 1 of Mean and variance of ratios of proportions from categories of a multinomial distribution

description: A script written in language R to perform custom numerical simulations and produce graphical output. (R 10 kb)
DOI: 10.6084/m9.figshare.5802123.v1
title: Additional file 1 of Mean and variance of ratios of proportions from categories of a multinomial distribution

description: A script written in language R to perform custom numerical simulations and produce graphical output. (R 10 kb)
DOI: 10.6084/m9.figshare.5802093
title: Additional file 2: of In-depth proteomic analysis of boar spermatozoa through shotgun and gel-based methods

description: Shotgun proteome data set analyses. File contains the total and abundant proteins, with associated functional analyses (Total protein_FA and abundant protein_FA). (XLSX 417Â kb)
DOI: 10.6084/m9.figshare.5802093.v1
title: Additional file 2: of In-depth proteomic analysis of boar spermatozoa through shotgun and gel-based methods

description: Shotgun proteome data set analyses. File contains the total and abundant proteins, with associated functional analyses (Total protein_FA and abundant protein_FA). (XLSX 417Â kb)
DOI: 10.6084/m9.figshare.5802024
title: Additional file 4: Dataset 5. of A reverse vaccinology approach to the identification and characterization of Ctenocephalides felis candidate protective antigens for the control of cat flea infestations

description: Proteomics data for cat flea and host proteins identified in the plasma membrane. (XLSX 26 kb)
DOI: 10.6084/m9.figshare.5802024.v1
title: Additional file 4: Dataset 5. of A reverse vaccinology approach to the identification and characterization of Ctenocephalides felis candidate protective antigens for the control of cat flea infestations

description: Proteomics data for cat flea and host proteins identified in the plasma membrane. (XLSX 26 kb)
DOI: 10.6084/m9.figshare.5801997
title: Additional file 3: Dataset 4. of A reverse vaccinology approach to the identification and characterization of Ctenocephalides felis candidate protective antigens for the control of cat flea infestations

description: Transcriptomics data analysis including predicted transcripts encoding proteins in the exoproteome. (XLS 17203 kb)
DOI: 10.6084/m9.figshare.5801997.v1
title: Additional file 3: Dataset 4. of A reverse vaccinology approach to the identification and characterization of Ctenocephalides felis candidate protective antigens for the control of cat flea infestations

description: Transcriptomics data analysis including predicted transcripts encoding proteins in the exoproteome. (XLS 17203 kb)
DOI: 10.6084/m9.figshare.5801982
title: Additional file 1: of Somatic evolutionary timings of driver mutations

description: Our designations of drivers using five annotation schemes, chromosomal positions, count of samples with mutant allele after Treeomics treatment, patient ID, and study information are shown. (XLSX 2387Â kb)
DOI: 10.6084/m9.figshare.5801982.v1
title: Additional file 1: of Somatic evolutionary timings of driver mutations

description: Our designations of drivers using five annotation schemes, chromosomal positions, count of samples with mutant allele after Treeomics treatment, patient ID, and study information are shown. (XLSX 2387Â kb)
DOI: 10.6084/m9.figshare.5801934
title: Additional file 1: of A five-year retrospective study of the epidemiological characteristics and visual outcomes of pediatric ocular trauma

description: Complete data set including all the data collected from the patients' records. (XLS 409 kb)
DOI: 10.6084/m9.figshare.5801934.v1
title: Additional file 1: of A five-year retrospective study of the epidemiological characteristics and visual outcomes of pediatric ocular trauma

description: Complete data set including all the data collected from the patients' records. (XLS 409 kb)
DOI: 10.6084/m9.figshare.5801910
title: Additional file 7: Table S7. of Radiation-induced pulmonary gene expression changes are attenuated by the CTGF antibody Pamrevlumab

description: Enrichment of RT and FG-3019 Responsive Genes and Cell-Type Distinguishing Genes in Other Public Lung RT Gene Sets. (XLSX 19Â kb)
DOI: 10.6084/m9.figshare.5801910.v1
title: Additional file 7: Table S7. of Radiation-induced pulmonary gene expression changes are attenuated by the CTGF antibody Pamrevlumab

description: Enrichment of RT and FG-3019 Responsive Genes and Cell-Type Distinguishing Genes in Other Public Lung RT Gene Sets. (XLSX 19Â kb)
DOI: 10.6084/m9.figshare.5801907
title: Additional file 3 of OpenBiodiv-O: ontology of the OpenBiodiv knowledge management system

description: RCC-5 Vocabulary is a plain text file containing statements in the Turtle syntax forming the OpenBiodiv RCC-5 Vocabulary. Like the ontology [Additional file 1] it can be edited in a text or ontology editor or loaded in a triple store. Make sure you also load the ontology first. (TXT 5 kb)
DOI: 10.6084/m9.figshare.5801907.v1
title: Additional file 3 of OpenBiodiv-O: ontology of the OpenBiodiv knowledge management system

description: RCC-5 Vocabulary is a plain text file containing statements in the Turtle syntax forming the OpenBiodiv RCC-5 Vocabulary. Like the ontology [Additional file 1] it can be edited in a text or ontology editor or loaded in a triple store. Make sure you also load the ontology first. (TXT 5 kb)
DOI: 10.6084/m9.figshare.5801892
title: Additional file 6: Table S6. of Radiation-induced pulmonary gene expression changes are attenuated by the CTGF antibody Pamrevlumab

description: Broad Gene Sets Associated with Radiation and FG-3019 Responsive Genes. (XLSX 18Â kb)
DOI: 10.6084/m9.figshare.5801892.v1
title: Additional file 6: Table S6. of Radiation-induced pulmonary gene expression changes are attenuated by the CTGF antibody Pamrevlumab

description: Broad Gene Sets Associated with Radiation and FG-3019 Responsive Genes. (XLSX 18Â kb)
DOI: 10.6084/m9.figshare.5801883
title: Additional file 2 of OpenBiodiv-O: ontology of the OpenBiodiv knowledge management system

description: Vocabulary of Taxonomic Statuses is a plain text file containing statements in the Turtle syntax forming the OpenBiodiv Vocabulary of Taxonomic Statuses. Like the ontology [Additional file 1] it can be edited in a text or ontology editor or loaded in a triple store. Make sure you also load the ontology first. (TXT 7 kb)
DOI: 10.6084/m9.figshare.5801883.v1
title: Additional file 2 of OpenBiodiv-O: ontology of the OpenBiodiv knowledge management system

description: Vocabulary of Taxonomic Statuses is a plain text file containing statements in the Turtle syntax forming the OpenBiodiv Vocabulary of Taxonomic Statuses. Like the ontology [Additional file 1] it can be edited in a text or ontology editor or loaded in a triple store. Make sure you also load the ontology first. (TXT 7 kb)
DOI: 10.6084/m9.figshare.5801871
title: Additional file 5; Table S5. of Radiation-induced pulmonary gene expression changes are attenuated by the CTGF antibody Pamrevlumab

description: GO categories associated with the RT-diminished gene set. (XLSX 12Â kb)