cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.15151/esrf-es-561456366
title: In situ mapping of deformation twinning evolution in Mg by nano-3DXRD CT

description: The proposal aims at investigating deformation twinning (DTw) processes in pure Mg, using nano-3DXRD CT, during in situ tensile testing, at several successive deformation steps and while the materials is under load. Crystal orientations, crystal defects and the full local stress tensor will be mapped in the materials during twin initiation and its progressive propagation. Single crystal and polycrystalline samples will be tested, with a focus on the role of slip in twin initiation and propagation mechanisms, as well and the stresses associated with twin-twin and twin-grain boundaries, and twin slip-planes interactions. After the test campaign at ESRF, post-mortem 3D HR-EBSD and detailed TEM analyses will be done on the deformed materials. These experiments will be a unique chance to close the gap between computer modelling and experiments. They will answer several fundamental and debated questions about the roles of local stresses and crystal defects in DTw mechanisms in hcp metals.
DOI: 10.15151/esrf-es-561460108
title: Operando RIXS and HERFD-XAS on a Ni+/TiO2/Ti3+ photocatalyst for noble metal- and sacrificial agent-free photocatalytic H2 production

description: Aim of this proposal is to perform operando XAS measurements on an aqueous reduced-TiO2 photocatalyst slurry in the presence of Ni(II) ions under light illumination. Such experimental conditions were recently found to trigger the formation of monovalent Ni species (Ni(I)), as observed by in-situ EPR results, which can catalyze H2 production without the need of a sacrificial agent or noble metal co-catalyst. Ni(I) formation is likely dependent on the presence in the reduced-TiO2 nanoparticles ('grey' titania) of surface Ti(III) sites, thus creating an artificial redox chain based on a monovalent nickel (Ni(I)) electron transfer relay. To corroborate the mechanism, we propose the use of High Energy Resolution Fluorescence Detected (HERFD) X-ray Absorption Spectroscopy and Resonant Inelastic X-ray Scattering (RIXS) at the Ni and Ti K-edges, to study in operando the local electronic and atomic structure of Ti and Ni under photocatalytic H2 evolution conditions.
DOI: 10.15151/esrf-es-561464028
title: Effect of charge excitations and electron-phonon coupling on the robust superconductivity in tri-layer cuprate Bi2Sr2Ca2Cu3O10+x

description: The superconductivity in tri-layer cuprate Bi2Sr2Ca2Cu3O10+x (Bi2223) is intriguing, not only because it has the highest Tc,max (~110K) among Bi-family, but also the Tc shows a negligible reduction with overdoping. This is very surprising since this obviously violates the Tc dome that is deemed a universal trend for cuprates. However, there is still no consensus on why the Tc is so robust in the overdoped Bi2223. Here we propose to use the high resolution resonant inelastic X-ray scattering (RIXS) to examine the T-dependence of charge excitations and electron-phonon coupling (EPC) in optimally and overdoped Bi2223, which are reported to entangle with the superconducting phase of cuprates. The aim is to determine their correlations with the robust high Tc and find out the essential factor for the high Tc superconductivity in Bi2223. The answer can reveal the nature of the highest Tc in tri-layer cuprates and provide insights on how to raise Tc.
DOI: 10.15151/esrf-es-569319391
title: Analysis of subcellular localization of celestine (SrSO4) crystals in marine unicellular eukaryotes

description: Organisms highly concentrate certain elements from their environment. Far less about this is known in unicellular eukaryotes (= protists) than in multicellular organisms, although protists constitute the majority of eukaryotic diversity. We have found large amount of celestine (SrSO4) with admixtures of barite (BaSO4) crystals enclosed in vacuoles of unicellular marine protists belonging to the group Diplonemidae. Micro-XRF in frozen-hydrated intact cells will allow artefact-free intracellular localization of Sr and Ba or celestine and barite (e.g. in cytoplasm, vacuoles, cell surface incrustations etc.), with much better resolution and quantification than previous EDX analyses of diplonemids. Furthermore, assessing intraspecific and intrastagial differences in their distribution and morphology will hint to the uptake, formation and function of celestine and barite. We believe that such an in-depth study of these elements in eukaryotic cells is unprecedented.
DOI: 10.15151/esrf-es-601734237
title: Dynamics in bismuth and hydrogenated metallic glasses

description: We will study alpha relaxations in under-cooled Bi and hydrogenated metallic glasses containing elements having different chemical affinity with hydrogen.
DOI: 10.15151/esrf-es-561456851
title: Operando coherent X-ray diffraction imaging of a single catalyst PtRh nanoparticle and surface X-ray diffraction of surface oxides

description: We aim to relate the Rh segregation-induced compositional strain state inside a single PtRh nanoparticle under catalytic CO oxidation/reduction conditions to the formation of surface oxides by using single nanoparticle surface X-ray diffraction. We will track the facet-dependent surface oxide formation of a single epitaxial Pt60Rh40 nanoparticle while following the catalytic activity by analysing the exhaust gas composition by online mass spectroscopy. The X-ray diffraction data will be correlated with UHV-STM measurements from the identical nanoparticle surface at DESY NanoLab in similar oxidizing/reducing environments. The experiment will elucidate how changes in the nanoparticle strain arise due to the formation of surface oxides and address the open questions on the atomic scale mechanisms in forming the nanoparticle facet-dependent surface oxides, and the role of Rh segregation towards the surface in the catalytic activity.
DOI: 10.6084/m9.figshare.17021807
title: Supplementary Material for: MicroRNA 1228 Mediates the Viability of High Glucose-Cultured Renal Tubule Cells through Targeting Thrombospondin 2 and PI3K/AKT Signaling Pathway

description: <b><i>Aim:</i></b> The present study aimed to elucidate the potential function of microRNA 1228 (miR-1228) on the high glucose (HG)-damaged human renal proximal tubule cells (HK-2) and the underlying mechanism. <b><i>Methods:</i></b> The datasets GSE47185 and GSE51674 were downloaded from the Gene Expression Omnibus database for mining differently expressed mRNAs and miRNAs, respectively. Bioinformatics online tools were applied to predict the binding sites between miR-1228 and thrombospondin 2 (THBS2), which was confirmed by dual-luciferase assay. Real-time quantitative polymerase chain reaction was used to detect the mRNA level of miR-1228/THBS2. Western blot was used to detect the protein level of THBS2 and the PI3K/AKT signaling pathway-associated markers. HK-2 cells were cultured in HG (30 mM) to mimic hyperglycemia. Cell counting kit 8 and flow cytometry assays were utilized to determine the cell proliferation and apoptosis. <b><i>Results:</i></b> The expression of THBS2 was significantly upregulated in diabetic nephropathy (DN) based on bioinformatics tools and identified as a direct target of miR-1228. miR-1228 was downregulated in DN and HG-damaged HK-2 cells. HG notably reduced HK-2 cell proliferation. This negative effect was attenuated by transfecting with an miR-1228 mimic and aggravated by transfecting with an miR-1228 inhibitor. However, under basal condition, there was no significant effect on the HK-2 cell proliferation among blank control, mimic, and inhibitor groups. Overexpression of THBS2 abolished the elevating effect of the miR-1228 mimic on the HG-damaged HK-2 cell proliferation, while restored the inhibitory effects of the miR-1228 mimic on the cell apoptosis. On the contrary, the suppressive effects on the proliferation and the enhancive effects on the apoptosis by silencing miR-1228 in HK-2 cells stimulated with HG can be weakened by recommendation of THBS2 small interference RNAs. Furthermore, we also found that HG significantly enhanced the phosphorylation levels of PI3K and AKT. In terms of overexpression and knockdown experiments, Western blot analysis further revealed that miR-1228 inhibited the activation of the PI3K/AKT signaling pathway in HG-damaged HK-2 cells by regulating THBS2. <b><i>Conclusion:</i></b> The findings illustrated that miR-1228 improved survivability and inhibited apoptosis in HK-2 cells stimulated with HG partly by restraining the activation of the PI3K/AKT signaling pathway.
DOI: 10.6084/m9.figshare.17021807.v1
title: Supplementary Material for: MicroRNA 1228 Mediates the Viability of High Glucose-Cultured Renal Tubule Cells through Targeting Thrombospondin 2 and PI3K/AKT Signaling Pathway

description: <b><i>Aim:</i></b> The present study aimed to elucidate the potential function of microRNA 1228 (miR-1228) on the high glucose (HG)-damaged human renal proximal tubule cells (HK-2) and the underlying mechanism. <b><i>Methods:</i></b> The datasets GSE47185 and GSE51674 were downloaded from the Gene Expression Omnibus database for mining differently expressed mRNAs and miRNAs, respectively. Bioinformatics online tools were applied to predict the binding sites between miR-1228 and thrombospondin 2 (THBS2), which was confirmed by dual-luciferase assay. Real-time quantitative polymerase chain reaction was used to detect the mRNA level of miR-1228/THBS2. Western blot was used to detect the protein level of THBS2 and the PI3K/AKT signaling pathway-associated markers. HK-2 cells were cultured in HG (30 mM) to mimic hyperglycemia. Cell counting kit 8 and flow cytometry assays were utilized to determine the cell proliferation and apoptosis. <b><i>Results:</i></b> The expression of THBS2 was significantly upregulated in diabetic nephropathy (DN) based on bioinformatics tools and identified as a direct target of miR-1228. miR-1228 was downregulated in DN and HG-damaged HK-2 cells. HG notably reduced HK-2 cell proliferation. This negative effect was attenuated by transfecting with an miR-1228 mimic and aggravated by transfecting with an miR-1228 inhibitor. However, under basal condition, there was no significant effect on the HK-2 cell proliferation among blank control, mimic, and inhibitor groups. Overexpression of THBS2 abolished the elevating effect of the miR-1228 mimic on the HG-damaged HK-2 cell proliferation, while restored the inhibitory effects of the miR-1228 mimic on the cell apoptosis. On the contrary, the suppressive effects on the proliferation and the enhancive effects on the apoptosis by silencing miR-1228 in HK-2 cells stimulated with HG can be weakened by recommendation of THBS2 small interference RNAs. Furthermore, we also found that HG significantly enhanced the phosphorylation levels of PI3K and AKT. In terms of overexpression and knockdown experiments, Western blot analysis further revealed that miR-1228 inhibited the activation of the PI3K/AKT signaling pathway in HG-damaged HK-2 cells by regulating THBS2. <b><i>Conclusion:</i></b> The findings illustrated that miR-1228 improved survivability and inhibited apoptosis in HK-2 cells stimulated with HG partly by restraining the activation of the PI3K/AKT signaling pathway.
DOI: 10.5285/bebfd99e-f2e3-46f0-9833-f59efb40be37
title: The Satellite Risk Prediction and Radiation Forecast System (SaRIF)

description: The SaRIF system forecasts the outer electron radiation up to 24 hours ahead, updated every hour. Risk indicators are provided for four satellite orbits and can be compared against design standards The SaRIF system provides a searchable archive of data for anomaly resolution by satellite operators, designers and underwriters. Funding was provided by ESA contract 4000118861/16/D/MRP (SSA P2-SWE-XIII proto-type)
description: Data Sources : GOES data : https://www.ngdc.noaa.gov/stp/satellite/goes/index.html DSCOVR data : https://www.ngdc.noaa.gov/dscovr/portal/index.html DST data : https://www.ngdc.noaa.gov/stp/geomag/dst.html Giove A data : ESTEC (European Space Research and Technology Centre), ESA, Noordwijk, Netherlands REFM/HEF data : Meteorological Office, Fitzroy Road, Exeter, Devon The date/times are all expressed in UTC.
description: This data is from an operational real-time system, the data is immediate and by its nature is the best available at the time required.
DOI: 10.5517/ccdc.csd.cc28z5l1
title: CCDC 2114373: Experimental Crystal Structure Determination

description: Related Article: Takumi Nukazawa, Takeaki Iwamoto|2021|Organometallics|40|3511|doi:10.1021/acs.organomet.1c00521
DOI: 10.6084/m9.figshare.17021903
title: sing environmental awareness and product development are two separate and costly investments that many small and medium-

description: Raising environmental awareness and product development are two separate and costly investments that many small and medium-sized fashion businesses cannot afford to achieve sustainability. Therefore, there is a need to decide which factors more significantly impact consumer loyalty and purchase intention toward eco-friendly fashion. Thus, the study employs a mixed-methods approach to research how customers' perception about product-service quality and their environmental awareness and pro-environmental behavior impact purchase intention and customer loyalty toward eco-friendly fashion products among Vietnamese Gen Z's. Most interviewees acknowledged that their primary source of knowledge for eco-friendly fashion was social media. The qualitative results further show that the knowledge and attitude toward eco-friendly fashion practices are insufficient to convince young customers to afford eco-friendly fashion products. The quantitative results show that while customer-related factors play a more significant role in stimulating purchase intention, only product-service quality factors impact loyalty. Hence, the study suggests that businesses should prioritize improving service and product quality rather than funding green marketing when targeting the Vietnamese Gen Z. Government should prioritize financial and technological support for fashion firms to develop high-quality eco-friendly fashion to ensure the availability of products in the market.
DOI: 10.6084/m9.figshare.17021903.v1
title: Promoting Eco-friendly Fashion among Youth Generation in Developing Countries: Mixed-methods study on The Roles of Price Value Image, Customer Fulfillment, and Pro-environmental Behavior: SEM-PLS Quantitative Data

description: Raising environmental awareness and product development are two separate and costly investments that many small and medium-sized fashion businesses cannot afford to achieve sustainability. Therefore, there is a need to decide which factors more significantly impact consumer loyalty and purchase intention toward eco-friendly fashion. Thus, the study employs a mixed-methods approach to research how customers' perception about product-service quality and their environmental awareness and pro-environmental behavior impact purchase intention and customer loyalty toward eco-friendly fashion products among Vietnamese Gen Z's. Most interviewees acknowledged that their primary source of knowledge for eco-friendly fashion was social media. The qualitative results further show that the knowledge and attitude toward eco-friendly fashion practices are insufficient to convince young customers to afford eco-friendly fashion products. The quantitative results show that while customer-related factors play a more significant role in stimulating purchase intention, only product-service quality factors impact loyalty. Hence, the study suggests that businesses should prioritize improving service and product quality rather than funding green marketing when targeting the Vietnamese Gen Z. Government should prioritize financial and technological support for fashion firms to develop high-quality eco-friendly fashion to ensure the availability of products in the market.
DOI: 10.6084/m9.figshare.17021879.v1
title: Promoting Eco-friendly Fashion among Youth Generation in Developing Countries: Mixed-methods study on The Roles of Price Value Image, Customer Fulfillment, and Pro-environmental Behavior: English Transcription

description: Raising environmental awareness and product development are two separate and costly investments that many small and medium-sized fashion businesses cannot afford to achieve sustainability. Therefore, there is a need to decide which factors more significantly impact consumer loyalty and purchase intention toward eco-friendly fashion. Thus, the study employs a mixed-methods approach to research how customers' perception about product-service quality and their environmental awareness and pro-environmental behavior impact purchase intention and customer loyalty toward eco-friendly fashion products among Vietnamese Gen Z's. Most interviewees acknowledged that their primary source of knowledge for eco-friendly fashion was social media. The qualitative results further show that the knowledge and attitude toward eco-friendly fashion practices are insufficient to convince young customers to afford eco-friendly fashion products. The quantitative results show that while customer-related factors play a more significant role in stimulating purchase intention, only product-service quality factors impact loyalty. Hence, the study suggests that businesses should prioritize improving service and product quality rather than funding green marketing when targeting the Vietnamese Gen Z. Government should prioritize financial and technological support for fashion firms to develop high-quality eco-friendly fashion to ensure the availability of products in the market.
DOI: 10.6084/m9.figshare.17021912
title: Supplementary Material for: A Scoping Review of Alternative Anticoagulation Strategies for Hemodialysis Patients with a Mechanical Heart Valve

description: <b><i>Introduction:</i></b> Patients with end-stage renal disease (ESRD) have high rates of cardiac valvulopathy but can develop contraindications for vitamin K antagonist (VKA) therapy. We explored the evidence for alternative anticoagulation strategies in patients with ESRD with a contraindication for VKA therapy. <b><i>Methods:</i></b> A scoping review was completed, searching MEDLINE, Embase, Cochrane Central Register of Controlled Trials, Web of Science, and Conference abstracts from inception to March 30, 2021. The study population was patients with ESRD who were on VKA therapy and developed a contraindication to VKA therapy use. All data regarding studies, patient characteristics, anticoagulation strategy, and clinical outcomes were summarized. <b><i>Results:</i></b> Twenty-three articles met inclusion criteria. These articles included 57 patients. Contraindications to VKA therapy included calcific uremic arteriolopathy (CUA) (<i>n</i> = 55) and warfarin-induced skin necrosis (<i>n</i> = 2). All studies were either case reports or case series. There were 10 anticoagulation strategies identified. Continuation of VKA therapy was associated with increased death and decreased rates of CUA resolution (80.0% and 10.0%, respectively), compared to apixaban (24.0% and 70.8%), subcutaneous (SC) low-molecular-weight heparin (LMWH) (14.3%, 85.7%), and SC unfractionated heparin (0.0%, 100.0%). While only 5 patient cases were reported with mechanical heart valves, SC LMWH use has been reported in this context with good outcomes. <b><i>Conclusions:</i></b> In patients with ESRD who develop a contraindication to VKA therapy, several alternative anticoagulation strategies have been reported with superior outcomes to VKA continuation. While outcomes appear superior to continuation of VKA therapy, more data are required before definitive recommendations can be made for the patient with ESRD and a mechanical heart valve.
DOI: 10.6084/m9.figshare.17021819
title: Supplementary Material for: Demographic and Clinical Characteristics of Individuals with Mild Cognitive Impairment Related to Grade of Alcohol Consumption

description: <b><i>Introduction:</i></b> While alcohol overconsumption is regarded as a risk factor for Alzheimer’s disease, the specific relationship between alcohol consumption and cognitive impairment remains unclear and poorly understood. Our primary objective is to investigate whether alcohol consumption is associated with lower cognitive performance at an early phase of the development of cognitive impairment (mild cognitive impairment [MCI] stage) and second to present the clinical and demographic characteristics depending on the grade of alcohol consumption. <b><i>Methods:</i></b> This is a cross-sectional observational study, including 251 subjects with the diagnosis MCI, having caregiving contact with Memory Clinic, Karolinska University Hospital, under year 2015. We compared subgroups with different levels of alcohol consumption, concerning social parameters, cognitive, radiological, laboratory profile as well as comorbidities and burden of drugs. <b><i>Results:</i></b> Mini-mental State Examination score was not associated with alcohol consumption. Light to moderate drinkers were significantly higher educated. There were significantly more subjects using antianxiety medications among heavy drinkers in comparison with light to moderate drinkers. Finally, never/rare drinkers had significantly lower levels of erythrocyte mean corpuscular volume in their blood tests. <b><i>Discussion/Conclusion:</i></b> Alcohol consumption was not correlated with a more pronounced cognitive deficit or a distinct clinical severity at an early stage of cognitive impairment apart from higher usage of antianxiety medications. We are planning to follow up all individuals to ascertain if heavy drinkers have a different outcome compared with the other groups.
DOI: 10.6084/m9.figshare.17021819.v1
title: Supplementary Material for: Demographic and Clinical Characteristics of Individuals with Mild Cognitive Impairment Related to Grade of Alcohol Consumption

description: <b><i>Introduction:</i></b> While alcohol overconsumption is regarded as a risk factor for Alzheimer’s disease, the specific relationship between alcohol consumption and cognitive impairment remains unclear and poorly understood. Our primary objective is to investigate whether alcohol consumption is associated with lower cognitive performance at an early phase of the development of cognitive impairment (mild cognitive impairment [MCI] stage) and second to present the clinical and demographic characteristics depending on the grade of alcohol consumption. <b><i>Methods:</i></b> This is a cross-sectional observational study, including 251 subjects with the diagnosis MCI, having caregiving contact with Memory Clinic, Karolinska University Hospital, under year 2015. We compared subgroups with different levels of alcohol consumption, concerning social parameters, cognitive, radiological, laboratory profile as well as comorbidities and burden of drugs. <b><i>Results:</i></b> Mini-mental State Examination score was not associated with alcohol consumption. Light to moderate drinkers were significantly higher educated. There were significantly more subjects using antianxiety medications among heavy drinkers in comparison with light to moderate drinkers. Finally, never/rare drinkers had significantly lower levels of erythrocyte mean corpuscular volume in their blood tests. <b><i>Discussion/Conclusion:</i></b> Alcohol consumption was not correlated with a more pronounced cognitive deficit or a distinct clinical severity at an early stage of cognitive impairment apart from higher usage of antianxiety medications. We are planning to follow up all individuals to ascertain if heavy drinkers have a different outcome compared with the other groups.