cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.5484250.v1
title: Supplementary Material for: Meta-Analysis of Lipid-Lowering Therapy in Maintenance Dialysis Patients

description: <b><i>Background/Aims:</i></b> The use of lipid-lowering therapy (LLT) in patients on chronic dialysis is contentious. Here we present an aggregate data meta-analysis of randomised controlled trials (RCTs) comparing long-term LLT versus placebo in dialysis patients. <b><i>Method:</i></b> A search of Medline, Google Scholar, COCHRANE database, EMBASE, and cardiovascular and nephrology society proceedings was performed. Criteria for inclusion were RCTs of LLT versus placebo, in which LLT was demonstrated to significantly reduce low-density lipoprotein cholesterol, &gt;12 months of follow-up, and at least one cardiovascular or mortality endpoint in an independently reported dialysis population. Meta-analysis was performed for atherosclerotic cardiovascular events, stroke and mortality using a random-effects method for odds ratio (OR) of risk. <b><i>Results:</i></b> Three studies were included with 7,051 patients (3,541 treatment and 3,510 placebo). Twenty-five percent of the LLT patients suffered an atherosclerotic cardiovascular event versus 27% for placebo. The OR was 0.89 (95% CI: 0.80-0.99, p = 0.04). For stroke (haemorrhagic and non-haemorrhagic combined), the figures were 6.2% (LLT) versus 5.7% (placebo) [OR = 1.11 (95% CI: 0.85-1.46, p = 0.45)]. For all-cause mortality, the figures were 40 versus 42% [OR = 0.97 (95% CI: 0.88-1.06, p = 0.49)]. <b><i>Conclusion:</i></b> There was an overall significant reduction in risk for atherosclerotic cardiovascular events in dialysis patients treated with LLT compared to placebo. There was a numerical but not a statistical reduction in mortality. There was no statistically significant increase in risk of stroke as has been previously reported.
DOI: 10.6084/m9.figshare.5484235
title: Alexander Hayes PhD Literature Review - Search Results: Peer Reviewed Journal Articles

description: This document serves to inform the reader of the process by which search activity results were obtained from across scholarly literature databases, provides search parameters for each search activity and relevant quantitative data tables showing search results. This secondary data supports the outcomes of the research thesis titled ‘<i>The Socio-ethical Implications of Body-Worn Video Recorders: An Ethnographic Study</i>’ due for publication in late 2019.
DOI: 10.6084/m9.figshare.5484241
title: Unravelling the core microbiome of biofilms in cooling tower systems

description: In this study, next generation sequencing and catalyzed reporter deposition fluorescence <i>in situ</i> hybridization, combined with confocal microscopy, were used to provide insights into the biodiversity and structure of biofilms collected from four full-scale European cooling systems. Water samples were also analyzed to evaluate the impact of suspended microbes on biofilm formation. A common core microbiome, containing members of the families Sphingomonadaceae, Comamonadaceae and Hyphomicrobiaceae, was found in all four biofilms, despite the water of each coming from different sources (river and groundwater). This suggests that selection of the pioneer community was influenced by abiotic factors (temperature, pH) and tolerances to biocides. Members of the Sphingomonadaceae were assumed to play a key role in initial biofilm formation. Subsequent biofilm development was driven primarily by light availability, since biofilms were dominated by phototrophs in the two studied ‘open’ systems. Their interactions with other microbial populations then shaped the structure of the mature biofilm communities analyzed.
DOI: 10.6084/m9.figshare.5484241.v1
title: Unravelling the core microbiome of biofilms in cooling tower systems

description: In this study, next generation sequencing and catalyzed reporter deposition fluorescence <i>in situ</i> hybridization, combined with confocal microscopy, were used to provide insights into the biodiversity and structure of biofilms collected from four full-scale European cooling systems. Water samples were also analyzed to evaluate the impact of suspended microbes on biofilm formation. A common core microbiome, containing members of the families Sphingomonadaceae, Comamonadaceae and Hyphomicrobiaceae, was found in all four biofilms, despite the water of each coming from different sources (river and groundwater). This suggests that selection of the pioneer community was influenced by abiotic factors (temperature, pH) and tolerances to biocides. Members of the Sphingomonadaceae were assumed to play a key role in initial biofilm formation. Subsequent biofilm development was driven primarily by light availability, since biofilms were dominated by phototrophs in the two studied ‘open’ systems. Their interactions with other microbial populations then shaped the structure of the mature biofilm communities analyzed.
DOI: 10.6084/m9.figshare.5484235.v1
title: 2017-Alexander-Hayes-PhD-Thesis-Literature-Review-Search-Results.pdf

description: This document serves to inform the reader of the process by which search activity results were obtained from across scholarly literature databases, provides search parameters for each search activity and relevant quantitative data tables showing search results. This secondary data supports the outcomes of the research thesis titled ‘The Socio-ethical Implications of Body-Worn Video Recorders: An Ethnographic Study’ due for publication in late 2018.
DOI: 10.6084/m9.figshare.5484235.v3
title: Alexander Hayes PhD Thesis Literature Review Search Results

description: This document serves to inform the reader of the process by which search activity results were obtained from across scholarly literature databases, provides search parameters for each search activity and relevant quantitative data tables showing search results. This secondary data supports the outcomes of the research thesis titled ‘<i>The Socio-ethical Implications of Body-Worn Video Recorders: An Ethnographic Study</i>’ due for publication in late 2019.
DOI: 10.6084/m9.figshare.5484235.v2
title: 2017-Alexander-Hayes-PhD-Thesis-Literature-Review-Search-Results

description: This document serves to inform the reader of the process by which search activity results were obtained from across scholarly literature databases, provides search parameters for each search activity and relevant quantitative data tables showing search results. This secondary data supports the outcomes of the research thesis titled ‘The Socio-ethical Implications of Body-Worn Video Recorders: An Ethnographic Study’ due for publication in late 2018.
DOI: 10.6084/m9.figshare.5484184
title: Supplementary Material for: Investigating the Role of Cardiovascular Biomarkers in Children with Pre-Dialysis Chronic Kidney Disease: A Substitute to Echocardiography to Detect Increased Left Ventricular Mass?

description: <b><i>Background:</i></b> Children with chronic kidney disease (CKD) are at increased risk of future cardiovascular (CV) events. Our aim in this prospective single-centre cross-sectional analysis was to assess the relationship of a novel panel of CV biomarkers with left ventricular hypertrophy (LVH). <b><i>Methods:</i></b> A panel of five CV biomarkers (asymmetric dimethyl arginine, high sensitivity C-reactive protein, homocysteine, N-terminal pro-B type natriuretic peptide and uric acid) were measured on the same day as an echocardiogram assessment, in paediatric patients with pre-dialysis stages 3-5 of CKD. <b><i>Results:</i></b> Of 73 children aged 5-18 years, LVH, all eccentric, was identified in 38%. Systolic blood pressure (BP), glomerular filtration rate (GFR) and higher intake of calcium-based phosphate binders were significantly worse in children with LVH. In multivariate models analysing each biomarker one at a time with confounders [GFR, systolic BP z-score, anti-hypertensive medication (yes/no) and elemental calcium intake], clinic systolic BP z-score and elemental calcium intake consistently displayed a significant relationship with indexed left ventricular mass (LVMI). None of the evaluated CV biomarkers displayed a significant relationship with LVMI. <b><i>Conclusions:</i></b> In our cohort of children with moderately severe pre-dialysis CKD we have identified no suitable biomarkers to detect LVH. We would therefore recommend that echocardiographic determination of LVMI remains the technique of choice for detection of LVH in children with CKD.
DOI: 10.6084/m9.figshare.5484178
title: Dickinson et al raw data.xlsx

description: growth curves of WT and mutant PSA strains, BAL cell counts, lung cfu counts, neutrophil apoptosis<br>
DOI: 10.6084/m9.figshare.5484178.v1
title: Dickinson et al raw data.xlsx

description: growth curves of WT and mutant PSA strains, BAL cell counts, lung cfu counts, neutrophil apoptosis<br>
DOI: 10.6084/m9.figshare.5484160
title: Supplementary Material for: Suboptimal Initiation of Home Hemodialysis: Determinants and Clinical Outcomes

description: <b><i>Background/Aims:</i></b> Suboptimal initiation of conventional hemodialysis is associated with poor clinical outcomes. In this study, we aimed to ascertain the determinants and adverse events associated with suboptimal starts in home hemodialysis (HHD). <b><i>Methods:</i></b> We conducted a retrospective cohort study including consecutive incident HHD patients from January 1996 to December 2011. All patients had HHD as their first renal replacement therapy or returned to HHD after kidney transplantation. A suboptimal start was defined by dialysis initiation as an inpatient or with a central venous catheter. The primary outcome was time to first hospitalization, technique failure or death. Secondary outcomes included hospitalization rate, hospital days and determinants of suboptimal starts. Suboptimal starts were further categorized as unavoidable as adjudicated by two independent observers with prespecified criteria. <b><i>Results:</i></b> Among 95 incident HHD patients, 44 (46%) and 51 (54%) had optimal and suboptimal starts, respectively. A suboptimal start was associated with a shorter time to the primary outcome (log-rank p &lt; 0.001). In a multivariable Cox proportional hazards model, the hazard ratio for the composite outcome (comparing suboptimal to optimal starts) was 2.94 (95% confidence interval, CI, 1.49-5.78, p = 0.002). Transplantation clinic follow-up (OR 3.18, 95% CI 1.15-8.79) and the Charlson comorbidity index (OR 1.47, 95% CI 1.09-1.97) were associated with higher odds of suboptimal start. <b><i>Conclusion:</i></b> Suboptimal initiation of HHD is associated with adverse clinical events including early hospitalization. Given the high proportion of suboptimal starts in patients returning from transplantation, better incorporation of dialysis planning and renal replacement therapy education is warranted.
DOI: 10.6084/m9.figshare.5484160.v1
title: Supplementary Material for: Suboptimal Initiation of Home Hemodialysis: Determinants and Clinical Outcomes

description: <b><i>Background/Aims:</i></b> Suboptimal initiation of conventional hemodialysis is associated with poor clinical outcomes. In this study, we aimed to ascertain the determinants and adverse events associated with suboptimal starts in home hemodialysis (HHD). <b><i>Methods:</i></b> We conducted a retrospective cohort study including consecutive incident HHD patients from January 1996 to December 2011. All patients had HHD as their first renal replacement therapy or returned to HHD after kidney transplantation. A suboptimal start was defined by dialysis initiation as an inpatient or with a central venous catheter. The primary outcome was time to first hospitalization, technique failure or death. Secondary outcomes included hospitalization rate, hospital days and determinants of suboptimal starts. Suboptimal starts were further categorized as unavoidable as adjudicated by two independent observers with prespecified criteria. <b><i>Results:</i></b> Among 95 incident HHD patients, 44 (46%) and 51 (54%) had optimal and suboptimal starts, respectively. A suboptimal start was associated with a shorter time to the primary outcome (log-rank p &lt; 0.001). In a multivariable Cox proportional hazards model, the hazard ratio for the composite outcome (comparing suboptimal to optimal starts) was 2.94 (95% confidence interval, CI, 1.49-5.78, p = 0.002). Transplantation clinic follow-up (OR 3.18, 95% CI 1.15-8.79) and the Charlson comorbidity index (OR 1.47, 95% CI 1.09-1.97) were associated with higher odds of suboptimal start. <b><i>Conclusion:</i></b> Suboptimal initiation of HHD is associated with adverse clinical events including early hospitalization. Given the high proportion of suboptimal starts in patients returning from transplantation, better incorporation of dialysis planning and renal replacement therapy education is warranted.
DOI: 10.6084/m9.figshare.5484109
title: Data set file for the following article: Functional visual fields: A cross-sectional study to determine which visual field paradigms best reflect difficulty with mobility function

description: 50 adult participants with peripheral field impairment were recruited in this data set. Participants undertook three custom and one standard binocular VF tests assessing visual field to 60 degrees, and also integrated monocular threshold 24-2 visual fields (IVF). Primary VF outcomes were average mean threshold, percentage of stimuli seen, and VF area. VF outcomes were compared to self-reported mobility function assessed with the Independent Mobility Questionnaire, and time taken and patient acceptability were also considered. <br>The data includes the following information about 50 participants: gender, age, sight loss registration status, use of mobility & low vision aids, history of falling, clinical function data including binocular VA, binocular CS, and visual field results from 5 different assessments, visual field test durations, and self-reported mobility function person measures.
DOI: 10.6084/m9.figshare.5484100
title: Raw experimental and numerical data from Indentation of a floating elastic sheet: geometry versus applied tension

description: This folder includes the raw experimental and numerical data that is used to produce the plots presented in the paper, together with the matlab codes necessary to generate these figures.
DOI: 10.6084/m9.figshare.5484109.v1
title: Data set file for the following article: Functional visual fields: A cross-sectional study to determine which visual field paradigms best reflect difficulty with mobility function

description: 50 adult participants with peripheral field impairment were recruited in this data set. Participants undertook three custom and one standard binocular VF tests assessing visual field to 60 degrees, and also integrated monocular threshold 24-2 visual fields (IVF). Primary VF outcomes were average mean threshold, percentage of stimuli seen, and VF area. VF outcomes were compared to self-reported mobility function assessed with the Independent Mobility Questionnaire, and time taken and patient acceptability were also considered. <br>The data includes the following information about 50 participants: gender, age, sight loss registration status, use of mobility & low vision aids, history of falling, clinical function data including binocular VA, binocular CS, and visual field results from 5 different assessments, visual field test durations, and self-reported mobility function person measures.
DOI: 10.6084/m9.figshare.5484100.v1
title: Raw experimental and numerical data from Indentation of a floating elastic sheet: geometry versus applied tension

description: This folder includes the raw experimental and numerical data that is used to produce the plots presented in the paper, together with the matlab codes necessary to generate these figures.
DOI: 10.6084/m9.figshare.5484019
title: Supplementary Material for: The Role of the Mineralocorticoid Receptor in Inflammation: Focus on Kidney and Vasculature

description: <i>Background:</i> The remarkable success of clinical trials in mineralocorticoid receptor (MR) inhibition in heart failure has driven research on the physiological and pathological role(s) of nonepithelial MR expression. MR is widely expressed in the cardiovascular system and is a major determinant of endothelial function, smooth muscle tone, vascular remodeling, fibrosis, and blood pressure. An important new dimension is the appreciation of the role MR plays in immune cells and target organ damage in the heart, kidney and vasculature, and in the development of insulin resistance. <i>Summary:</i> The mechanism for MR activation in tissue injury continues to evolve with the evidence to date suggesting that activation of MR results in a complex repertoire of effects involving both macrophages and T cells. MR is an important transcriptional regulator of macrophage phenotype and function. Another important feature of MR activation is that it can occur even with normal or low aldosterone levels in pathological conditions. Tissue-specific conditional models of MR expression in myeloid cells, endothelial cells, smooth muscle cells and cardiomyocytes have been very informative and have firmly demonstrated a critical role of MR as a key pathophysiologic variable in cardiac hypertrophy, transition to heart failure, adipose inflammation, and atherosclerosis. Finally, the central nervous system activation of MR in permeable regions of the blood-brain barrier may play a role in peripheral inflammation. <i>Key Message:</i> Ongoing clinical trials will help clarify the role of MR blockade in conditions, such as atherosclerosis and chronic kidney disease.
DOI: 10.6084/m9.figshare.5484010
title: [DATA_SCIENCE] Interviews PomBase Users, January-February 2016

description: Here you find the transcripts of interviews collected by Sabina Leonelli as part of the ERC project "The Epistemology of Data-Intensive Science". You also find the information sheet provided to interviewees, which gives you the context for this project. Further information and related publications can be found at www.datastudies.eu. One paper that specifically makes use of these interviews was published by Sabina Leonelli in the journal Philosophy of Science in 2018, under the title "Data in Time: Time-Scales of Data Use in the Life Sciences." The transcripts document yeast researchers' attitudes to data curation and the use of databases in their field. Researchers have consented to have these transcripts made available as Open Data. Other interviewees did not give consent, so those transcripts are held securely by the research team in Exeter. <br>
DOI: 10.6084/m9.figshare.5484019.v1
title: Supplementary Material for: The Role of the Mineralocorticoid Receptor in Inflammation: Focus on Kidney and Vasculature

description: <i>Background:</i> The remarkable success of clinical trials in mineralocorticoid receptor (MR) inhibition in heart failure has driven research on the physiological and pathological role(s) of nonepithelial MR expression. MR is widely expressed in the cardiovascular system and is a major determinant of endothelial function, smooth muscle tone, vascular remodeling, fibrosis, and blood pressure. An important new dimension is the appreciation of the role MR plays in immune cells and target organ damage in the heart, kidney and vasculature, and in the development of insulin resistance. <i>Summary:</i> The mechanism for MR activation in tissue injury continues to evolve with the evidence to date suggesting that activation of MR results in a complex repertoire of effects involving both macrophages and T cells. MR is an important transcriptional regulator of macrophage phenotype and function. Another important feature of MR activation is that it can occur even with normal or low aldosterone levels in pathological conditions. Tissue-specific conditional models of MR expression in myeloid cells, endothelial cells, smooth muscle cells and cardiomyocytes have been very informative and have firmly demonstrated a critical role of MR as a key pathophysiologic variable in cardiac hypertrophy, transition to heart failure, adipose inflammation, and atherosclerosis. Finally, the central nervous system activation of MR in permeable regions of the blood-brain barrier may play a role in peripheral inflammation. <i>Key Message:</i> Ongoing clinical trials will help clarify the role of MR blockade in conditions, such as atherosclerosis and chronic kidney disease.
DOI: 10.6084/m9.figshare.5484010.v1
title: [DATA_SCIENCE] Interviews PomBase Users, January-February 2016

description: Here you find the transcripts of interviews collected by Sabina Leonelli as part of the ERC project "The Epistemology of Data-Intensive Science". You also find the information sheet provided to interviewees, which gives you the context for this project. Further information and related publications can be found at www.datastudies.eu. One paper that specifically makes use of these interviews was published by Sabina Leonelli in the journal Philosophy of Science in 2018, under the title "Data in Time: Time-Scales of Data Use in the Life Sciences." The transcripts document yeast researchers' attitudes to data curation and the use of databases in their field. Researchers have consented to have these transcripts made available as Open Data. Other interviewees did not give consent, so those transcripts are held securely by the research team in Exeter. <br>
DOI: 10.6084/m9.figshare.5483974
title: Need For Sleep - Replication package

description: Replication package for "<i>Need for Sleep: the Impact of a Night of Sleep Deprivation on Developers' Performance"</i><br>Please, see README file for more information.
DOI: 10.6084/m9.figshare.5483974.v3
title: Need For Sleep - Replication package

description: Replication package for "<i>Need for Sleep: the Impact of a Night of Sleep Deprivation on Developers' Performance"</i><br>Please, see README file for more information.
DOI: 10.6084/m9.figshare.5483974.v2
title: Need For Sleep - Replication package

description: Replication package for "<i>Need for Sleep: the Impact of a Night of Sleep Deprivation on Developers' Performance"</i><br>Please, see README file for more information.
DOI: 10.6084/m9.figshare.5483875
title: Tuzun_2017_AnimalBehaviour.xlsx

description: Data used for the paper: Pesticide-induced changes in personality depend on the urbanisation level (Tüzün et al. 2017)<b></b>
DOI: 10.6084/m9.figshare.5483839
title: Supplementary Material for: Insulin Regimens to Treat Hyperglycemia in Hospitalized Patients on Nutritional Support: Systematic Review and Meta-Analyses

description: <i>Background:</i> The best insulin regimen to treat hyperglycemia in hospitalized patients on nutritional support (NS) is unclear. <i>Methods:</i> We searched electronic databases to identify cohort studies or randomized clinical trials in order to evaluate the efficacy of different insulin regimens used to treat hyperglycemia in hospitalized patients on NS on diverse outcomes: mean blood glucose (MBG), hypoglycemia, length of stay in hospital, and mortality. <i>Results:</i> Seventeen studies from a total of 5,030 were included. Enteral Group included 8 studies; 1,203 patients using rapid, glargine, NPH, or Premix insulin; MBG 108-225 mg/dL; hypoglycemia 0-13%. In indirect meta-analyses, NPH insulin ranked best for glucose control (MD 95% CI -2.50 mg/dL [2.65 to -2.35]). Parenteral Group included 4 studies; 228 patients using regular and glargine or NPH insulin; MBG 137-202 mg/dL; hypoglycemia 0-40%. In meta-analyses comparing regular insulin added to parenteral nutrition bag with glargine, MBG (MD 95% CI -3.78 mg/dL [-11.93 to 4.37]; <i>I</i>2 = 0%) or hypoglycemia frequency (RR 95% CI 1.37 [0.43-4.32]; <i>I</i>2 = 70.7%) did not differ. The description related to hospital length of stay and mortality was inconsistent between groups. <i>Conclusions:</i> The best insulin regimen to treat hyperglycemia in hospitalized patients on NS has not been established; best results using insulin regimens with NPH in enteral nutrition do not seem to be clinically relevant.